P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04398	p53 pathway feedback loops 2	P04651	Ras	BOVIN|Ensembl=ENSBTAG00000009778|UniProtKB=E1BMX0	Uncharacterized protein	ISS	9869449	PubMed	PTHR24070:SF186	GTPASE KRAS
P04395	Vasopressin synthesis	P04594	Neurophysin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00018	EGF receptor signaling pathway	P00558	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00029	Huntington disease	P00805	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	ARATH|TAIR=AT5G36880|UniProtKB=B9DGD6	Acetyl-coenzyme A synthetase, chloroplastic/glyoxysomal	ISS			PTHR24095:SF14	ACETYL-COENZYME A SYNTHETASE 1
P00056	VEGF signaling pathway	P01425	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	3045562	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04665	AKT	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	ISS	14526383	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04651	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00005	Angiogenesis	P00256	PLC-gamma	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00057	Wnt signaling pathway	P01451	Galpha	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00053	T cell activation	P01311	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00296	DAXX	MOUSE|MGI=MGI=1197015|UniProtKB=O35613	Death domain-associated protein 6	ISS	9215629	PubMed	PTHR12766:SF7	DEATH DOMAIN-ASSOCIATED PROTEIN 6
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	RCA	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	HUMAN|HGNC=11430|UniProtKB=Q86Y82	Syntaxin-12	IC	14570579	PubMed	PTHR19957:SF88	SYNTAXIN-12
P00036	Interleukin signaling pathway	P00976	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04392	P53 pathway feedback loops 1	P04539	p53	PANTR|Ensembl=ENSPTRG00000008703|UniProtKB=H2QC53	Cellular tumor antigen p53	ISS	11313951	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P04395	Vasopressin synthesis	P04593	Glycopeptide	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	IC	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04398	p53 pathway feedback loops 2	P04668	p53	ORNAN|Ensembl=ENSOANG00000013795|UniProtKB=F7DUR2	Uncharacterized protein (Fragment)	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P05734	Synaptic vesicle trafficking	P05776	RIM1alpha/2alpha	MACMU|Ensembl=ENSMMUG00000010345|UniProtKB=F6R888	Uncharacterized protein	ISS	11343654	PubMed	PTHR12157:SF19	REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	7925653	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MACMU|Ensembl=ENSMMUG00000012054|UniProtKB=F6TII3	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	RCA	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01148	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	10521483	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04393	Ras Pathway	P04565	MKK4/7	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00049	Parkinson disease	P01211	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	HUMAN|HGNC=5724|UniProtKB=Q06330	Recombining binding protein suppressor of hairless	NAS	8406481	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P02743	Formyltetrahydroformate biosynthesis	P02954	Thymidylate synthase	HUMAN|HGNC=12441|UniProtKB=P04818	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P04392	P53 pathway feedback loops 1	P04539	p53	DANRE|ZFIN=ZDB-GENE-990415-270|UniProtKB=P79734	Cellular tumor antigen p53	TAS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DROME|FlyBase=FBgn0015765|UniProtKB=O62618	Mitogen-activated protein kinase 14A	IDA	11707292	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	8838325	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	MOUSE|MGI=MGI=96828|UniProtKB=Q91ZX7	Prolow-density lipoprotein receptor-related protein 1	IDA	11907044	PubMed	PTHR44025:SF2	PROLOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1
P02772	Pyruvate metabolism	P03132	Pyruvate Kinase	CHICK|Ensembl=ENSGALG00000001992|UniProtKB=P00548	Pyruvate kinase PKM	ISS	8193145	PubMed	PTHR11817:SF15	PYRUVATE KINASE PKM
P04398	p53 pathway feedback loops 2	G04708	WIP-1	BOVIN|Ensembl=ENSBTAG00000009427|UniProtKB=E1BD03	Uncharacterized protein	ISS			PTHR13832:SF359	PROTEIN PHOSPHATASE 1D
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IC	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00302	ATF	BOVIN|Ensembl=ENSBTAG00000005863|UniProtKB=F1N1U0	Uncharacterized protein	ISS	11390664	PubMed	PTHR19304:SF10	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-7
P00049	Parkinson disease	P01238	14-3-3	BOVIN|Ensembl=ENSBTAG00000000236|UniProtKB=P63103	14-3-3 protein zeta/delta	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00018	EGF receptor signaling pathway	P00549	EGF	MOUSE|MGI=MGI=96083|UniProtKB=Q6DR99	Neuregulin 1	RCA			PTHR11100:SF7	PRO-NEUREGULIN-1, MEMBRANE-BOUND ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01446	Calcineurin	ARATH|TAIR=AT5G24270|UniProtKB=O81223	Calcineurin B-like protein 4	IDA	12015605	PubMed	PTHR23056:SF45	CALCINEURIN B-LIKE PROTEIN 4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00045	Notch signaling pathway	P01116	Delta	PANTR|Ensembl=ENSPTRG00000006937|UniProtKB=H2R342	Delta-like protein	ISS	11798067	PubMed	PTHR24044:SF320	DELTA-LIKE PROTEIN 4
P00053	T cell activation	P01333	cdc42	TAKRU|Ensembl=ENSTRUG00000008289|UniProtKB=H2T7U8	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF129	CDC42L PROTEIN
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	IDA	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00052	TGF-beta signaling pathway	P01284	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00060	Ubiquitin proteasome pathway	P01492	E1	BOVIN|Ensembl=ENSBTAG00000002573|UniProtKB=A4FV12	UBA2 protein	ISS			PTHR10953:SF5	SUMO-ACTIVATING ENZYME SUBUNIT 2
P00005	Angiogenesis	P00243	Raf	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00036	Interleukin signaling pathway	P00970	Interleukin	HUMAN|HGNC=5973|UniProtKB=P35225	Interleukin-13	IC			PTHR45413:SF1	INTERLEUKIN-13
P05918	p38 MAPK pathway	P06015	p38gamma	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	RCA	8925912	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00005	Angiogenesis	P00244	MAPKAPK2/3	MACMU|Ensembl=ENSMMUG00000023567|UniProtKB=F7HHY8	Uncharacterized protein	ISS	7923354	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P02778	Sulfate assimilation	P03167	Sulfate adenylyltransferase	XENTR|Xenbase=XB-GENE-947140|UniProtKB=Q6DIN0	3'-phosphoadenosine 5'-phosphosulfate synthase 1	ISS			PTHR11055:SF17	BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE 1
P00021	FGF signaling pathway	P00631	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	8235613	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	PANTR|Ensembl=ENSPTRG00000017091|UniProtKB=H2QR92	Proprotein convertase subtilisin/kexin type 1	ISS			PTHR42884:SF14	NEUROENDOCRINE CONVERTASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	PANTR|Ensembl=ENSPTRG00000015131|UniProtKB=H2QMZ1	Uncharacterized protein	ISS			PTHR22778:SF26	DIHYDROFOLATE REDUCTASE, MITOCHONDRIAL
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	HUMAN|HGNC=1442|UniProtKB=P62158	Calmodulin	IDA	3885394	PubMed	PTHR23050:SF311	CALMODULIN
P00046	Oxidative stress response	P01135	p38	CAEBR|Gene=CBG01555|UniProtKB=A8WRD7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00048	PI3 kinase pathway	P01188	Gbetagamma	BRAFL|Gene=BRAFLDRAFT_220697|UniProtKB=C3ZSF0	Putative uncharacterized protein	ISS	9740024	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05915	Opioid proenkephalin pathway	P05991	Enkephalin	DANRE|ZFIN=ZDB-GENE-030729-31|UniProtKB=A8E7S2	Uncharacterized protein	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	MACMU|Ensembl=ENSMMUG00000005432|UniProtKB=F7GQ56	Clathrin heavy chain	ISS	9388255	PubMed	PTHR10292:SF6	CLATHRIN HEAVY CHAIN 2
P00020	FAS signaling pathway	P00615	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00012	Cadherin signaling pathway	P00465	TCF/LEF	XENTR|Xenbase=XB-GENE-485517|UniProtKB=F6WCX0	Uncharacterized protein	ISS	11266476	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00059	p53 pathway	G04702	p53	CANLF|Gene=TP53|UniProtKB=Q29537	Cellular tumor antigen p53	TAS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00643	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00013	Cell cycle	P00480	Proteasome	RAT|RGD=1359305|UniProtKB=Q5XIC6	Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 12	ISS	9426256	PubMed	PTHR10855:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TRIVA|Gene=TVAG_337240|UniProtKB=P90623	Actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00557	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	MOUSE|MGI=MGI=2661081|UniProtKB=Q8K348	Activin receptor type-1C	ISS	10683140	PubMed	PTHR23255:SF58	ACTIVIN RECEPTOR TYPE-1C
P02752	Mannose metabolism	P03017	Mannose 6-P isomerase	CAEEL|WormBase=WBGene00015464|UniProtKB=O16315	Uncharacterized protein	TAS			PTHR10309:SF2	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01192	p110	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00805	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000015130|UniProtKB=H2QMZ0	Uncharacterized protein	ISS	11067767	PubMed	PTHR19957:SF29	SYNTAXIN-19
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=1306541|UniProtKB=D3ZVF3	Phosphoinositide-3-kinase, class 2, beta polypeptide (Predicted)	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00036	Interleukin signaling pathway	P00975	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	8270251	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P06587	Nicotine pharmacodynamics pathway	P06593	CHRNA5	HUMAN|HGNC=1959|UniProtKB=P30532	Neuronal acetylcholine receptor subunit alpha-5	ISS	85270494	PubMed	PTHR18945:SF76	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5
P04393	Ras Pathway	P04550	Ral	MONDO|Ensembl=ENSMODG00000000264|UniProtKB=F6WB97	Uncharacterized protein	ISS	7687439	PubMed	PTHR24070:SF199	RAS-RELATED PROTEIN RAL-B
P00012	Cadherin signaling pathway	P00470	F-actin	XENTR|Xenbase=XB-GENE-6469705|UniProtKB=Q6P8G3	Actin, alpha sarcomeric/skeletal	ISS	11889139	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000000771|UniProtKB=F6SSS3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00059	p53 pathway	P04623	CBP	CAEEL|WormBase=WBGene00010545|UniProtKB=G5EBG3	CBP/p300 homolog	ISS	10823891	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04393	Ras Pathway	P04570	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00053	T cell activation	P01300	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00047	PDGF signaling pathway	P01171	PLCgamma	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P02783	Tryptophan biosynthesis	P03211	Phosphribosyl anthranilate isomerase	AQUAE|EnsemblGenome=aq_2076|UniProtKB=O67853	N-(5'-phosphoribosyl)anthranilate isomerase	ISS			PTHR42894:SF1	N- 5'-PHOSPHORIBOSYL ANTHRANILATE ISOMERASE
P00018	EGF receptor signaling pathway	P00559	MEK1-2	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IGI	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05939	GRK6	MOUSE|MGI=MGI=1347078|UniProtKB=O70293	G protein-coupled receptor kinase 6	RCA	8288567	PubMed	PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	EMENI|EnsemblGenome=CADANIAG00002670|UniProtKB=Q5BH99	G-protein beta subunit [Source:UniProtKB/TrEMBLAcc:O74214]	ISS	10523303	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P02742	Tetrahydrofolate biosynthesis	P02951	GTP cyclohydrolase	FUSNN|EnsemblGenome=FN0071|UniProtKB=Q8RH43	GTP cyclohydrolase 1	ISS			PTHR11109:SF0	GTP CYCLOHYDROLASE 1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	PYRAE|EnsemblGenome=PAE2164|UniProtKB=Q8ZVR0	TATA-box-binding protein	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05731	GABA-B receptor II signaling	P05752	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	HUMAN|HGNC=129|UniProtKB=P68133	Actin, alpha skeletal muscle	IDA	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	HUMAN|HGNC=6264|UniProtKB=P48549	G protein-activated inward rectifier potassium channel 1	IDA			PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00019	Endothelin signaling pathway	P00572	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MOUSE|MGI=MGI=1339711|UniProtKB=Q5SX40	Myosin-1	ISS	10938134	PubMed	PTHR13140:SF484	MYOSIN-1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	XENTR|Xenbase=XB-GENE-482841|UniProtKB=F7E8W8	Uncharacterized protein (Fragment)	ISS	12834808	PubMed	PTHR10201:SF29	72 KDA TYPE IV COLLAGENASE
P00021	FGF signaling pathway	P00642	MEK1-2	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05918	p38 MAPK pathway	P06015	p38gamma	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	RCA	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00021	FGF signaling pathway	P00627	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	11251832	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00010	B cell activation	P00385	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00018	EGF receptor signaling pathway	P00547	PP2A	TAKRU|Ensembl=ENSTRUG00000003840|UniProtKB=H2S9H8	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00045	Notch signaling pathway	P01110	Presenilin	DROME|FlyBase=FBgn0019947|UniProtKB=O02194	Presenilin homolog	TAS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00048	PI3 kinase pathway	P01199	Galpha	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01435	SWI/SNF	MACMU|Ensembl=ENSMMUG00000019539|UniProtKB=F7CQX8	Uncharacterized protein	ISS	11532957	PubMed	PTHR10799:SF731	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A-LIKE PROTEIN 1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01143	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	20331588	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00010	B cell activation	P00383	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00034	Integrin signalling pathway	P00925	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IDA	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	PANTR|Ensembl=ENSPTRG00000006342|UniProtKB=H2Q8A8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	TAS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00009	Axon guidance mediated by netrin	P00366	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00034	Integrin signalling pathway	P00925	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00049	Parkinson disease	P01219	SAPK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	NAS	8946915	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04393	Ras Pathway	P04558	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00053	T cell activation	P01305	Calmodulin	ORYSJ|EnsemblGenome=OS05G0491100|UniProtKB=Q6F332	Calmodulin-2	ISS	10487978	PubMed	PTHR23050:SF324	CALMODULIN-2-RELATED
P00005	Angiogenesis	P00219	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05731	GABA-B receptor II signaling	P05758	K channel	CHICK|Gene=KCNJ3|UniProtKB=Q90854	G protein-activated inward rectifier potassium channel 1	RCA	12374786	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00006	Apoptosis signaling pathway	P00278	Bag	RAT|RGD=1305203|UniProtKB=B0K019	BAG family molecular chaperone regulator 1	ISS	7834747	PubMed	PTHR12329:SF16	BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01322	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IDA	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Ensembl=ENSCAFG00000032542|UniProtKB=J9P639	Uncharacterized protein	ISS	11259487	PubMed	PTHR24229:SF1	KAPPA-TYPE OPIOID RECEPTOR
P00021	FGF signaling pathway	P00624	14-3-3	CHICK|Ensembl=ENSGALG00000010725|UniProtKB=Q5ZKC9	14-3-3 protein zeta	ISS	12615066	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P05731	GABA-B receptor II signaling	P05754	Ggamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	RAT|RGD=1584995|UniProtKB=Q63379	N-myc proto-oncogene protein	IEP	12356903	PubMed	PTHR11514:SF3	N-MYC PROTO-ONCOGENE PROTEIN
P05918	p38 MAPK pathway	P06031	p38alpha	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04393	Ras Pathway	P04570	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04392	P53 pathway feedback loops 1	P04539	p53	RAT|RGD=3889|UniProtKB=P10361	Cellular tumor antigen p53	TAS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00060	Ubiquitin proteasome pathway	P01491	E2	CANLF|Ensembl=ENSCAFG00000015284|UniProtKB=E2RKT9	Uncharacterized protein	ISS	10888878	PubMed	PTHR24068:SF67	UBIQUITIN-CONJUGATING ENZYME E2 L3
P05731	GABA-B receptor II signaling	P05752	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1718748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01159	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01148	Grb2	BOVIN|Ensembl=ENSBTAG00000003707|UniProtKB=A6QLK6	GRB2-related adapter protein	ISS	8051109	PubMed	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P00017	DNA replication	P00531	Pol alpha	TRYB2|Gene=Tb927.8.4880|UniProtKB=Q57UW4	DNA polymerase	IEP	92093600	PubMed	PTHR10322:SF21	DNA POLYMERASE ALPHA CATALYTIC SUBUNIT
P00059	p53 pathway	P01486	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00566	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00805	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00053	T cell activation	P01300	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04496	Mdm2	MOUSE|MGI=MGI=107934|UniProtKB=O35618	Protein Mdm4	ISS			PTHR13844:SF20	PROTEIN MDM4
P00048	PI3 kinase pathway	P01204	GPCR	MOUSE|MGI=MGI=97795|UniProtKB=P30557	Prostaglandin E2 receptor EP3 subtype	ISS	14607241	PubMed	PTHR11866:SF10	PROSTAGLANDIN E2 RECEPTOR EP3 SUBTYPE
P00019	Endothelin signaling pathway	P00586	Gq	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PANTR|Ensembl=ENSPTRG00000002086|UniProtKB=H2Q1A9	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00018	EGF receptor signaling pathway	G01511	SPRY	MACMU|Ensembl=ENSMMUG00000014175|UniProtKB=F7ALK4	Uncharacterized protein	ISS	10330503	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	IC	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04407	K+ channel	MACMU|Ensembl=ENSMMUG00000005826|UniProtKB=F6VE51	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00034	Integrin signalling pathway	P00925	MEK	MOUSE|MGI=MGI=1346869|UniProtKB=P47809	Dual specificity mitogen-activated protein kinase kinase 4	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00048	PI3 kinase pathway	P01199	Galpha	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	IC	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	IDA	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00056	VEGF signaling pathway	P01402	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	RCA			PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02741	Flavin biosynthesis	P02935	GTP cyclohydrolase	ARATH|TAIR=AT5G64300|UniProtKB=P47924	Bifunctional riboflavin biosynthesis protein RIBA 1, chloroplastic	ISS			PTHR21327:SF9	BIFUNCTIONAL RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBA 1, CHLOROPLASTIC
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	BOVIN|Ensembl=ENSBTAG00000002647|UniProtKB=Q2KHW7	Regulator of G-protein signaling 10	ISS	8756726	PubMed	PTHR10845:SF182	REGULATOR OF G-PROTEIN SIGNALING 10
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00545	JNK1-3	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IGI			PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04393	Ras Pathway	P04559	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	MONDO|Ensembl=ENSMODG00000014763|UniProtKB=F7GGT3	Uncharacterized protein	ISS			PTHR23409:SF20	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	IDA	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_188187|UniProtKB=E9GJ31	Guanine nucleotide binding protein, q polypeptide	ISS	14765990	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00047	PDGF signaling pathway	P01161	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00016	Cytoskeletal regulation by Rho GTPase	P00520	Rho GAPs	MONDO|Ensembl=ENSMODG00000019894|UniProtKB=F6W5V4	Uncharacterized protein	ISS	14724572	PubMed	PTHR23176:SF28	RHO GTPASE-ACTIVATING PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	HUMAN|HGNC=7882|UniProtKB=Q04721	Neurogenic locus notch homolog protein 2	IDA	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	CHICK|Ensembl=ENSGALG00000006885|UniProtKB=P08642	GTPase HRas	ISS	87226391	PubMed	PTHR24070:SF385	GTPASE HRAS
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	CAEEL|WormBase=WBGene00004769|UniProtKB=P52166	Presenilin sel-12	IDA	7566091	PubMed	PTHR10202:SF13	PRESENILIN-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	ISS	9166716	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	YEAST|SGD=S000001550|UniProtKB=P36010	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	HUMAN|HGNC=4616|UniProtKB=P49840	Glycogen synthase kinase-3 alpha	IDA	12086949	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04494	TSC2	RAT|RGD=3908|UniProtKB=P49816	Tuberin	IDA	12150915	PubMed	PTHR10063:SF0	TUBERIN
P04393	Ras Pathway	P04541	p90RSK	HUMAN|HGNC=10432|UniProtKB=P51812	Ribosomal protein S6 kinase alpha-3	IDA	2779569	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	10218114	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00051	TCA cycle	P01267	Citrate Synthase	DICPU|Gene=DICPUDRAFT_50173|UniProtKB=F0ZX52	Citrate synthase	ISS	15225305	PubMed	PTHR11739:SF4	CITRATE SYNTHASE, PEROXISOMAL
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P02785	Valine biosynthesis	P03216	Acetolactate synthase	MYCTU|EnsemblGenome=Rv1820|UniProtKB=P9WG39	Acetolactate synthase large subunit IlvG	ISS			PTHR18968:SF156	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00034	Integrin signalling pathway	P00912	Arp2/3	CANLF|Ensembl=ENSCAFG00000015094|UniProtKB=F1PT97	Uncharacterized protein	ISS	12932731	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00048	PI3 kinase pathway	P01182	Ras	CAEBR|Gene=CBG06092|UniProtKB=A8X0X5	Protein CBR-LET-60	ISS	22022015	PubMed	PTHR24070:SF385	GTPASE HRAS
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P02741	Flavin biosynthesis	P02940	Riboflavin synthase	RHOBA|EnsemblGenome=RB12379|UniProtKB=Q7UIR3	Riboflavin synthase alpha chain	ISS			PTHR21098:SF0	RIBOFLAVIN SYNTHASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=1919210|UniProtKB=Q6URW6	Myosin-14	ISS	89264452	PubMed	PTHR13140:SF462	MYOSIN-14
P04398	p53 pathway feedback loops 2	P04658	PTEN	XENTR|Xenbase=XB-GENE-491433|UniProtKB=B1H2U0	Pten protein	ISS	10555148	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00048	PI3 kinase pathway	P01192	p110	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04657	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00471	Cadherin	MONDO|Ensembl=ENSMODG00000003670|UniProtKB=F7ABP2	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF106	CADHERIN-18
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	HUMAN|HGNC=7882|UniProtKB=Q04721	Neurogenic locus notch homolog protein 2	IDA	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	DEIRA|EnsemblGenome=DR_B0109|UniProtKB=Q9RZL6	Ribonucleoside-diphosphate reductase, beta chain	ISS			PTHR23409:SF32	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT BETA
P00053	T cell activation	P01332	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_58093|UniProtKB=C3Z4K3	Putative uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00034	Integrin signalling pathway	P00944	Actin	BOVIN|Ensembl=ENSBTAG00000014614|UniProtKB=P62739	Actin, aortic smooth muscle	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MACMU|Ensembl=ENSMMUG00000013215|UniProtKB=F6X7X4	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF31	FRIZZLED-7
P00055	Transcription regulation by bZIP transcription factor	P01395	TFIIE	HUMAN|HGNC=4650|UniProtKB=P29083	General transcription factor IIE subunit 1	ISS	92065982	PubMed	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00045	Notch signaling pathway	G01541	E(spl)-C genes	PANTR|Ensembl=ENSPTRG00000024233|UniProtKB=H2R0I1	Uncharacterized protein	ISS	14973298	PubMed	PTHR10985:SF104	TRANSCRIPTION FACTOR HES-5
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IDA	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00029	Huntington disease	P00807	Actin	EMENI|EnsemblGenome=CADANIAG00007315|UniProtKB=P20359	Actin, gamma	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05918	p38 MAPK pathway	P06018	MNK1	RAT|RGD=1559603|UniProtKB=Q4G050	MAP kinase-interacting serine/threonine-protein kinase 1	ISS	9155017	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MACMU|Ensembl=ENSMMUG00000011029|UniProtKB=F7DCY3	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IDA	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01020	NSF	HUMAN|HGNC=8016|UniProtKB=P46459	Vesicle-fusing ATPase	ISS	11348590	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01369	MKK1	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00057	Wnt signaling pathway	P01444	Wnt	BRAFL|Gene=BRAFLDRAFT_118309|UniProtKB=C3YZ17	Protein Wnt	IDA	8717036	PubMed	PTHR12027:SF100	SUBFAMILY NOT NAMED
P06959	CCKR signaling map	P07227	KLF4	HUMAN|HGNC=6348|UniProtKB=O43474	Krueppel-like factor 4	RCA	14670968	PubMed	PTHR44778:SF1	KRUEPPEL-LIKE FACTOR 4
P00018	EGF receptor signaling pathway	P00562	p38	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	IGI	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	BOVIN|Ensembl=ENSBTAG00000019210|UniProtKB=F1MJV4	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00034	Integrin signalling pathway	P00936	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	IC	96320556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00053	T cell activation	P01336	Jnk	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00878	INFgamma	HUMAN|HGNC=5438|UniProtKB=P01579	Interferon gamma	TAS	11175845	PubMed	PTHR11419:SF0	INTERFERON GAMMA
P00001	Adrenaline and noradrenaline biosynthesis	P00068	amine translocator	XENTR|Xenbase=XB-GENE-5870378|UniProtKB=F6WWA2	Transporter	ISS	12719981	PubMed	PTHR11616:SF125	SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER B 0 AT1
P00036	Interleukin signaling pathway	P00965	ERK	MACMU|Ensembl=ENSMMUG00000001187|UniProtKB=F6R8N9	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P02774	Salvage pyrimidine deoxyribonucleotides	P03147	Thymidine kinase	HUMAN|HGNC=11830|UniProtKB=P04183	Thymidine kinase, cytosolic	ISS			PTHR11441:SF0	THYMIDINE KINASE, CYTOSOLIC
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00057	Wnt signaling pathway	P01451	Galpha	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00059	p53 pathway	P04633	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	SCHPO|PomBase=SPBC32H8.12c|UniProtKB=P10989	Actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00029	Huntington disease	P00790	beta-Tubulin	MACMU|Ensembl=ENSMMUG00000032572|UniProtKB=F7D7Y7	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00018	EGF receptor signaling pathway	P00565	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	IGI	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	BOVIN|Ensembl=ENSBTAG00000040329|UniProtKB=F1MMU1	Uncharacterized protein	ISS	12441358	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CANLF|Ensembl=ENSCAFG00000013148|UniProtKB=Q5R1P3	Glutamate receptor ionotropic, NMDA 2B	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MOUSE|MGI=MGI=95823|UniProtKB=Q03391	Glutamate receptor ionotropic, NMDA 2D	ISS	14698601	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P02741	Flavin biosynthesis	P02935	GTP cyclohydrolase	AQUAE|EnsemblGenome=aq_350|UniProtKB=O66679	Riboflavin biosynthesis protein RibBA	ISS			PTHR21327:SF32	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IDA	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00634	MEKK1-5	HUMAN|HGNC=6854|UniProtKB=Q9Y2U5	Mitogen-activated protein kinase kinase kinase 2	IGI	8649450	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	IDA	11956331	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF31	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-040426-2427|UniProtKB=F1Q6C0	Uncharacterized protein (Fragment)	ISS	3037538	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	IDA	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05730	Endogenous cannabinoid signaling	P05751	Galpha	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P02775	Salvage pyrimidine ribonucleotides	P03153	Cytidylate kinase	RAT|RGD=1310116|UniProtKB=Q4KM73	UMP-CMP kinase	ISS			PTHR23359:SF107	UMP-CMP KINASE
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	RAT|RGD=62030|UniProtKB=P02564	Myosin-7	ISS	89264452	PubMed	PTHR13140:SF344	MYOSIN-7
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MONDO|Ensembl=ENSMODG00000020204|UniProtKB=F6SED9	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	BOVIN|Ensembl=ENSBTAG00000017894|UniProtKB=F1MVC0	Uncharacterized protein	ISS			PTHR11405:SF5	CAD PROTEIN
P00019	Endothelin signaling pathway	P00586	Gq	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	IC	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CHICK|Ensembl=ENSGALG00000005123|UniProtKB=Q9DEB8	Protein Wnt	TAS	8717036	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00010	B cell activation	P00372	Grb2	BOVIN|Ensembl=ENSBTAG00000003707|UniProtKB=A6QLK6	GRB2-related adapter protein	ISS			PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=88354|UniProtKB=P09803	Cadherin-1	IDA	8120095	PubMed	PTHR24027:SF319	CADHERIN-1
P00038	JAK/STAT signaling pathway	P01033	PTP	CHICK|Ensembl=ENSGALG00000002192|UniProtKB=F1NVB1	Uncharacterized protein	ISS	1672451	PubMed	PTHR19134:SF284	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C
P00010	B cell activation	P00381	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P02738	De novo purine biosynthesis	P02894	IMP cyclohydrolase	DROME|FlyBase=FBgn0039241|UniProtKB=Q9VC18	RE29555p	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P00029	Huntington disease	P00811	Arp2/3 complex	BOVIN|Gene=ARPC5|UniProtKB=Q3SYX9	Actin-related protein 2/3 complex subunit 5	ISS	12932731	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	BOVIN|Ensembl=ENSBTAG00000008429|UniProtKB=F1ML31	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF4	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	GIAIC|EnsemblGenome=GL50803_40817|UniProtKB=A8BV70	Actin related protein	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IPI	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MOUSE|MGI=MGI=1354694|UniProtKB=Q9JL25	Regulator of G-protein signaling 1	IDA	10779778	PubMed	PTHR10845:SF34	REGULATOR OF G-PROTEIN SIGNALING 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	TAS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00644	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IGI	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=98956|UniProtKB=P27467	Protein Wnt-3a	IDA	11266476	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01078	VAChT	RAT|RGD=62072|UniProtKB=Q62666	Vesicular acetylcholine transporter	IC			PTHR23506:SF13	VESICULAR ACETYLCHOLINE TRANSPORTER
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_127489|UniProtKB=C3XYC6	Putative uncharacterized protein	IDA	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	HUMAN|HGNC=8528|UniProtKB=P01178	Oxytocin-neurophysin 1	ISS	192340	OMIM	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00060	Ubiquitin proteasome pathway	P01490	E3	ARATH|TAIR=AT2G46030|UniProtKB=P42750	Ubiquitin-conjugating enzyme E2 6	ISS			PTHR43946:SF2	UBIQUITIN-CONJUGATING ENZYME E2 H
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00024	Glycolysis	P00675	Pyruvate kinase	ARATH|TAIR=AT3G22960|UniProtKB=Q9LIK0	Plastidial pyruvate kinase 1, chloroplastic	TAS	18403597	gi	PTHR11817:SF14	PLASTIDIAL PYRUVATE KINASE 1, CHLOROPLASTIC
P00057	Wnt signaling pathway	P01434	sFRP	CHICK|Gene=SFRP2|UniProtKB=Q9IA96	Secreted frizzled-related protein 2	IDA	9096311	PubMed	PTHR11309:SF45	SECRETED FRIZZLED-RELATED PROTEIN 2
P00059	p53 pathway	P01486	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00005	Angiogenesis	P00207	Crk	CANLF|Ensembl=ENSCAFG00000015188|UniProtKB=E2RF98	Uncharacterized protein	ISS	8649368	PubMed	PTHR19969:SF9	CRK-LIKE PROTEIN
P00021	FGF signaling pathway	P00634	MEKK1-5	MOUSE|MGI=MGI=1346876|UniProtKB=O35099	Mitogen-activated protein kinase kinase kinase 5	ISS	8974401	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00590	IP3 R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00006	Apoptosis signaling pathway	P00269	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05730	Endogenous cannabinoid signaling	P05746	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00006	Apoptosis signaling pathway	P00310	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00373	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IGI	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MOUSE|MGI=MGI=88182|UniProtKB=P20722	Bone morphogenetic protein 6	TAS	9759503	PubMed	PTHR11848:SF137	BONE MORPHOGENETIC PROTEIN 6
P00010	B cell activation	P00381	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IGI	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00005	Angiogenesis	P00218	STAT1	HUMAN|HGNC=11362|UniProtKB=P42224	Signal transducer and activator of transcription 1-alpha/beta	IDA	10207096	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04542	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04559	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	20010089	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00057	Wnt signaling pathway	P01439	C-terminal Binding Protein	CANLF|Ensembl=ENSCAFG00000016687|UniProtKB=F1P620	Uncharacterized protein	ISS	10375506	PubMed	PTHR10996:SF128	C-TERMINAL-BINDING PROTEIN 1
P02752	Mannose metabolism	P03019	P-Mannose mutase	CANAL|CGD=CAL0000183926|UniProtKB=P31353	Phosphomannomutase	IDA	1473182	PubMed	PTHR10466:SF0	PHOSPHOMANNOMUTASE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	BOVIN|Ensembl=ENSBTAG00000013111|UniProtKB=F1MSF1	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00054	Toll receptor signaling pathway	P01355	AP1	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	11840290	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=1762|UniProtKB=P22223	Cadherin-3	IDA	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P00005	Angiogenesis	P00254	GTPase	MOUSE|MGI=MGI=107949|UniProtKB=P62746	Rho-related GTP-binding protein RhoB	ISS	11973360	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00034	Integrin signalling pathway	P00907	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00236	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04393	Ras Pathway	P04557	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	94313981	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00036	Interleukin signaling pathway	P00973	PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	ORNAN|Ensembl=ENSOANG00000005134|UniProtKB=F6WFN3	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF335	MYOSIN-11
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P02756	N-acetylglucosamine metabolism	P03041	Glucosamine-6-phosphate deaminase	ECOLI|EcoGene=EG11728|UniProtKB=P31470	Uncharacterized protein YieK	ISS			PTHR11280:SF5	GLUCOSAMINE-6-PHOSPHATE ISOMERASE
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IGI	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00049	Parkinson disease	P01242	Casein kinase I	ARATH|TAIR=AT3G13670|UniProtKB=Q9LID3	Casein kinase-like protein	IDA	11437445	PubMed	PTHR11909:SF289	CASEIN KINASE-LIKE PROTEIN
P00054	Toll receptor signaling pathway	P01369	MKK1	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00551	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00212	EphR	PANTR|Ensembl=ENSPTRG00000000320|UniProtKB=H2R9D1	Uncharacterized protein	ISS	9990854	PubMed	PTHR24416:SF123	EPHRIN TYPE-B RECEPTOR 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01153	GSK3	MACMU|Ensembl=ENSMMUG00000014597|UniProtKB=F6VAQ6	Glycogen synthase kinase-3 alpha	ISS	21361340	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00050	Plasminogen activating cascade	P01263	pro-MMP-1	BOVIN|Gene=MMP1|UniProtKB=P28053	Interstitial collagenase	ISS	95201294	PubMed	PTHR10201:SF151	INTERSTITIAL COLLAGENASE
P00056	VEGF signaling pathway	P01413	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00007	Axon guidance mediated by semaphorins	P00340	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P06959	CCKR signaling map	P07061	SOS1	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	RCA		PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	PANTR|Ensembl=ENSPTRG00000024064|UniProtKB=H2R3R2	Synaptotagmin I	ISS	11438518	PubMed	PTHR10024:SF239	SYNAPTOTAGMIN-1
P00053	T cell activation	P01314	nck	PANTR|Ensembl=ENSPTRG00000015434|UniProtKB=G2HHN0	Cytoplasmic protein NCK1	ISS	11689432	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P00012	Cadherin signaling pathway	P00474	Wnt	CAEBR|Gene=CBG03422|UniProtKB=A8WV10	Protein CBR-CWN-2	ISS	8717036	PubMed	PTHR12027:SF77	PROTEIN WNT-5
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00780	Microtubule	HUMAN|HGNC=20776|UniProtKB=Q9BUF5	Tubulin beta-6 chain	IDA	9454836	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	NAS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05917	Opioid proopiomelanocortin pathway	P06008	ACTH	MACMU|Ensembl=ENSMMUG00000016463|UniProtKB=F7GBI0	Uncharacterized protein	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00047	PDGF signaling pathway	P01156	PDGF receptor B	HUMAN|HGNC=8805|UniProtKB=Q15198	Platelet-derived growth factor receptor-like protein	ISS			PTHR15360:SF1	PLATELET-DERIVED GROWTH FACTOR RECEPTOR-LIKE PROTEIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	RAT|RGD=2735|UniProtKB=Q63273	Glutamate receptor ionotropic, kainate 5	ISS	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00018	EGF receptor signaling pathway	P00539	14-3-3	SCHMA|EnsemblGenome=Smp_034840|UniProtKB=G4V8A9	14-3-3 epsilon	IGI	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT1G01560|UniProtKB=Q9LMM5	Mitogen-activated protein kinase 11	ISS	10514528	PubMed	PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	BOVIN|Ensembl=ENSBTAG00000009125|UniProtKB=F1MHR3	Uncharacterized protein	ISS			PTHR11699:SF209	ALDEHYDE DEHYDROGENASE FAMILY 1 MEMBER A3
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00045	Notch signaling pathway	P01104	Serrate	HUMAN|HGNC=6189|UniProtKB=Q9Y219	Protein jagged-2	ISS			PTHR44097:SF1	PROTEIN JAGGED-2
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	MOUSE|MGI=MGI=109129|UniProtKB=Q62311	Transcription initiation factor TFIID subunit 6	ISS			PTHR10221:SF12	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6
P00006	Apoptosis signaling pathway	P00269	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00056	VEGF signaling pathway	P01417	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	MOUSE|MGI=MGI=1346037|UniProtKB=Q9WTL4	Insulin receptor-related protein	ISS	12644000	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	SCHPO|PomBase=SPBC4C3.07|UniProtKB=O43060	Eukaryotic translation initiation factor 3 subunit F	ISS			PTHR10540:SF6	EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04393	Ras Pathway	P04552	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00005	Angiogenesis	P00237	FRP	DANRE|ZFIN=ZDB-GENE-990715-1|UniProtKB=Q9W6E0	Frizzled-related protein	ISS	9118218	PubMed	PTHR11309:SF96	FRIZZLED-RELATED PROTEIN
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	ENTHI|EnsemblGenome=EHI_181250|UniProtKB=C4M5Z7	Rho family GTPase	ISS	97082968	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00021	FGF signaling pathway	P00623	FGF	MACMU|Ensembl=ENSMMUG00000014598|UniProtKB=F7GQ28	Fibroblast growth factor	ISS	12163055	PubMed	PTHR11486:SF31	FIBROBLAST GROWTH FACTOR 4
P05918	p38 MAPK pathway	P06039	MSK2	MACMU|Ensembl=ENSMMUG00000007610|UniProtKB=F6SDH6	Ribosomal protein S6 kinase	ISS	9792677	PubMed	PTHR24351:SF41	RIBOSOMAL PROTEIN S6 KINASE ALPHA-4
P00018	EGF receptor signaling pathway	P00543	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	11204774	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00034	Integrin signalling pathway	P00924	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IPI	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MOUSE|MGI=MGI=1933206|UniProtKB=A2AIR5	Protein Grin3a	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00180	Dok-R	RAT|RGD=1311840|UniProtKB=B2RYG7	Docking protein 3	ISS			PTHR21258:SF42	DOCKING PROTEIN 3
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01181	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00034	Integrin signalling pathway	P00942	Fyn	PANTR|Ensembl=ENSPTRG00000018511|UniProtKB=H2QTK7	Tyrosine-protein kinase	ISS	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00048	PI3 kinase pathway	P01193	IRS	CANLF|Ensembl=ENSCAFG00000010397|UniProtKB=E2RDB5	Uncharacterized protein	ISS	15110093	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00036	Interleukin signaling pathway	P00971	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00260	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00205	GAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04397	p53 pathway by glucose deprivation	P04641	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00181	SHP2	MACMU|Ensembl=ENSMMUG00000013253|UniProtKB=F6ZJD8	Tyrosine-protein phosphatase non-receptor type	ISS	95163101	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00053	T cell activation	P01330	IKK	CANLF|Ensembl=ENSCAFG00000005526|UniProtKB=E2RKR0	Uncharacterized protein	ISS	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00552	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P06216	SCW signaling pathway	P06320	PUT	DROME|Gene=Dmel_CG7904|UniProtKB=A0A0B4KG59	Serine/threonine-protein kinase receptor	IEA	http://flybase.org/reports/FBgn0003169.html	Website	PTHR23255:SF70	SERINE/THREONINE-PROTEIN KINASE RECEPTOR
P00049	Parkinson disease	P01227	20S proteasome	HUMAN|HGNC=9532|UniProtKB=P25788	Proteasome subunit alpha type-3	TAS	12859888	PubMed	PTHR11599:SF10	PROTEASOME SUBUNIT ALPHA TYPE-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	PANTR|Ensembl=ENSPTRG00000008771|UniProtKB=H2QCA0	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF484	MYOSIN-1
P00006	Apoptosis signaling pathway	P00318	PKCs	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=1336171|UniProtKB=Q9DAS9	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	BOVIN|Ensembl=ENSBTAG00000025274|UniProtKB=Q3MHM5	Tubulin beta-4B chain	ISS	12932731	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00052	TGF-beta signaling pathway	P01284	JNK	CAEEL|WormBase=WBGene00002187|UniProtKB=O44408	GLH-binding kinase 1	TAS			PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00034	Integrin signalling pathway	P00926	GRAF	BOVIN|Ensembl=ENSBTAG00000027151|UniProtKB=E1BNB7	Uncharacterized protein	ISS	8649427	PubMed	PTHR12552:SF4	RHO GTPASE-ACTIVATING PROTEIN 26
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	TAS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00060	Ubiquitin proteasome pathway	P01491	E2	HUMAN|HGNC=12492|UniProtKB=P61088	Ubiquitin-conjugating enzyme E2 N	ISS			PTHR43902:SF5	UBIQUITIN-CONJUGATING ENZYME E2 N
P00012	Cadherin signaling pathway	P00463	betacatenin	BOVIN|Ensembl=ENSBTAG00000016420|UniProtKB=Q0VCX4	Catenin beta-1	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P02781	Threonine biosynthesis	P03190	Threonine synthase	MYCTU|EnsemblGenome=Rv1295|UniProtKB=P9WG59	Threonine synthase	ISS			PTHR10314:SF5	THREONINE SYNTHASE 1, CHLOROPLASTIC
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	BOVIN|Ensembl=ENSBTAG00000000219|UniProtKB=F1MCL3	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00052	TGF-beta signaling pathway	P01286	TGFbeta	HUMAN|HGNC=7865|UniProtKB=Q96S42	Nodal homolog	TAS	9759503	PubMed	PTHR11848:SF159	NODAL HOMOLOG
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=1339711|UniProtKB=Q5SX40	Myosin-1	IC	10938134	PubMed	PTHR13140:SF484	MYOSIN-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	CAEEL|WormBase=WBGene00010436|UniProtKB=Q95QD6	Uncharacterized protein	ISS			PTHR11079:SF92	TRNA-SPECIFIC ADENOSINE DEAMINASE 2
P00004	Alzheimer disease-presenilin pathway	P00111	C99	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00036	Interleukin signaling pathway	P00964	p90RSK	MONDO|Ensembl=ENSMODG00000008086|UniProtKB=F6YJ34	Ribosomal protein S6 kinase	ISS	10558991	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P02784	Tyrosine biosynthesis	P03212	Chorismate mutase	ARATH|TAIR=AT1G69370|UniProtKB=Q9C544	Chorismate mutase 3, chloroplastic	ISS			PTHR21145:SF3	CHORISMATE MUTASE 3, CHLOROPLASTIC
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00237	FRP	MOUSE|MGI=MGI=108476|UniProtKB=Q61086	Frizzled-3	ISS	12549854	PubMed	PTHR11309:SF22	FRIZZLED-3
P00021	FGF signaling pathway	P00629	PP2A	ARATH|TAIR=AT1G10430|UniProtKB=Q07098	Serine/threonine-protein phosphatase PP2A-2 catalytic subunit	ISS			PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00645	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	CAEEL|WormBase=WBGene00004259|UniProtKB=Q18990	PYRimidine biosynthesis	ISS			PTHR11405:SF5	CAD PROTEIN
P00006	Apoptosis signaling pathway	P00269	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000022548|UniProtKB=F6Y9J9	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00018	EGF receptor signaling pathway	P00549	EGF	HUMAN|HGNC=3059|UniProtKB=Q99075	Proheparin-binding EGF-like growth factor	IGI	12882762	PubMed	PTHR10740:SF4	PROHEPARIN-BINDING EGF-LIKE GROWTH FACTOR
P00005	Angiogenesis	P00254	GTPase	HUMAN|HGNC=668|UniProtKB=P62745	Rho-related GTP-binding protein RhoB	ISS	13679859	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02742	Tetrahydrofolate biosynthesis	P02945	Dihydropteroate synthase	THEMA|EnsemblGenome=TM_0040|UniProtKB=Q9WXP7	Dihydropteroate synthase	ISS			PTHR20941:SF1	FOLIC ACID SYNTHESIS PROTEIN FOL1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	ISS	12787066	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00053	T cell activation	P01332	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IDA	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00463	betacatenin	RAT|RGD=70487|UniProtKB=Q9WU82	Catenin beta-1	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P05913	Enkephalin release	P05972	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	PANTR|Ensembl=ENSPTRG00000011741|UniProtKB=H2R8X1	Uncharacterized protein	ISS	10851247	PubMed	PTHR11647:SF58	DIHYDROPYRIMIDINASE-RELATED PROTEIN 5
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000018361|UniProtKB=P60020	5-hydroxytryptamine receptor 1B	ISS	11701344	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P00021	FGF signaling pathway	P00637	MKK4,7	MONDO|Ensembl=ENSMODG00000008266|UniProtKB=F6Z879	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00029	Huntington disease	P00786	ARF	XENTR|Xenbase=XB-GENE-998820|UniProtKB=Q28J03	ADP-ribosylation factor-like 7	ISS	12932731	PubMed	PTHR11711:SF119	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 4C
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00029	Huntington disease	P00807	Actin	TRIAD|EnsemblGenome=TriadG35956|UniProtKB=Q7YTV5	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00020	FAS signaling pathway	P00601	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00059	p53 pathway	P04616	PDK1/2	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	TAS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	IC	1333286	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	DROME|FlyBase=FBgn0030011|UniProtKB=Q9W3J1	Gbeta5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=69430|UniProtKB=P32851	Syntaxin-1A	IC	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04393	Ras Pathway	P04546	GSK3	BOVIN|Ensembl=ENSBTAG00000020756|UniProtKB=A6QLB8	GSK3A protein	ISS	183955	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	TAKRU|Ensembl=ENSTRUG00000006464|UniProtKB=H2STT5	Uncharacterized protein	ISS	10476970	PubMed	PTHR24070:SF382	RAS-RELATED PROTEIN RAP-1B
P00021	FGF signaling pathway	P00645	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	8649368	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00054	Toll receptor signaling pathway	P01376	Uev1A	DROME|FlyBase=FBgn0035601|UniProtKB=Q9VRL1	LD28904p	ISS			PTHR43915:SF5	LD28904P
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	ISS	2372396	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	BOVIN|Ensembl=ENSBTAG00000019963|UniProtKB=P28327	Rhodopsin kinase	IDA	8260489	PubMed	PTHR24355:SF11	RHODOPSIN KINASE
P00029	Huntington disease	P00780	Microtubule	CHICK|GeneID=396254|UniProtKB=P09244	Tubulin beta-7 chain	IDA	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00034	Integrin signalling pathway	P00916	Ras	CRYNJ|EnsemblGenome=CNA02810|UniProtKB=P0CQ42	Ras-like protein	IPI	7997267	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	BOVIN|Ensembl=ENSBTAG00000020756|UniProtKB=A6QLB8	GSK3A protein	ISS	2164470	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00019	Endothelin signaling pathway	P00587	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	RAT|RGD=2740|UniProtKB=Q62645	Glutamate receptor ionotropic, NMDA 2D	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	IC	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00034	Integrin signalling pathway	P00916	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00036	Interleukin signaling pathway	P00965	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IC	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	HUMAN|HGNC=6091|UniProtKB=P06213	Insulin receptor	ISS	6754360	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00015	Circadian clock system	G01497	cry	RAT|RGD=735083|UniProtKB=Q32Q86	Cryptochrome-1	IDA	14507900	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00022	General transcription by RNA polymerase I	P00652	RNA Polymerase I  Complex	BOVIN|Ensembl=ENSBTAG00000022539|UniProtKB=Q3ZBC0	DNA-directed RNA polymerases I, II, and III subunit RPABC4	ISS	12634356	PubMed	PTHR12056:SF2	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC4
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	IC	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00021	FGF signaling pathway	P00644	p38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	IGI	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00052	TGF-beta signaling pathway	P01284	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04542	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00203	Erk	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01311	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00642	MEK1-2	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00010	B cell activation	P00383	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IDA	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	IDA	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00038	JAK/STAT signaling pathway	P01027	STAT	MACMU|Ensembl=ENSMMUG00000010705|UniProtKB=F7G8V4	Signal transducer and activator of transcription	ISS	95188889	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00059	p53 pathway	G04694	p110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	HUMAN|HGNC=11364|UniProtKB=P40763	Signal transducer and activator of transcription 3	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	IC	96149441	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00021	FGF signaling pathway	P00644	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00057	Wnt signaling pathway	P01432	Beta-Catenin	CHICK|Ensembl=ENSGALG00000011905|UniProtKB=F1NHT7	Uncharacterized protein	IDA	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00012	Cadherin signaling pathway	P00474	Wnt	MACMU|Ensembl=ENSMMUG00000022937|UniProtKB=F6U717	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P00005	Angiogenesis	P00210	eNOS	MOUSE|MGI=MGI=97362|UniProtKB=P70313	Nitric oxide synthase, endothelial	ISS	22462730	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00001	Adrenaline and noradrenaline biosynthesis	P00061	PNMT	RAT|RGD=1597087|UniProtKB=D3ZNJ5	Protein Inmt	ISS			PTHR10867:SF6	INDOLETHYLAMINE N-METHYLTRANSFERASE-RELATED
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	DANRE|ZFIN=ZDB-GENE-990415-229|UniProtKB=Q8QFM3	Frizzled 7a	TAS	11212302	PubMed	PTHR11309:SF31	FRIZZLED-7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	DROME|FlyBase=FBgn0000317|UniProtKB=Q9V3Z6	Myosin-VIIa	IC			PTHR13140:SF703	MYOSIN 28B1, ISOFORM B-RELATED
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	ANOGA|EnsemblGenome=AGAP005913|UniProtKB=Q7Q6D2	AGAP005913-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ORYSJ|EnsemblGenome=OS05G0106600|UniProtKB=Q65XH8	Os05g0106600 protein	IC	10974003	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00010	B cell activation	P00385	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12912997	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	IDA	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P02763	Peptidoglycan biosynthesis	P03087	Glutamate racemase	BACSU|EnsemblGenome=BSU26810|UniProtKB=O05412	Glutamate racemase 2	ISS			PTHR21198:SF3	SUBFAMILY NOT NAMED
P00010	B cell activation	P00371	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	TAS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05734	Synaptic vesicle trafficking	P05774	NSF	CAEEL|WormBase=WBGene00003818|UniProtKB=Q94392	Vesicle-fusing ATPase	TAS	7969419	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00018	EGF receptor signaling pathway	P00557	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	ISS	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P00053	T cell activation	P01335	jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	12972619	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00899	IRS 1-4	BOVIN|Ensembl=ENSBTAG00000021308|UniProtKB=F1MYE0	Uncharacterized protein	ISS	5031805	gi	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00048	PI3 kinase pathway	P01192	p110	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00477	GSK3beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00012	Cadherin signaling pathway	P00470	F-actin	ANOGA|EnsemblGenome=AGAP000651|UniProtKB=P84185	Actin-5C	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	HUMAN|HGNC=6162|UniProtKB=P26010	Integrin beta-7	IDA	10741397	PubMed	PTHR10082:SF36	INTEGRIN BETA-7
P00019	Endothelin signaling pathway	P00585	ECE1-3	MOUSE|MGI=MGI=1101357|UniProtKB=Q4PZA2	Endothelin-converting enzyme 1	ISS	12464614	PubMed	PTHR11733:SF130	ENDOTHELIN-CONVERTING ENZYME 1
P00057	Wnt signaling pathway	P01444	Wnt	MACMU|Ensembl=ENSMMUG00000007765|UniProtKB=F7CW57	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000010521|UniProtKB=F7DQK7	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00049	Parkinson disease	P01234	GRK	MACMU|Ensembl=ENSMMUG00000015925|UniProtKB=F7AL30	Protein-serine/threonine kinase	ISS	10852916	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MOUSE|MGI=MGI=1919210|UniProtKB=Q6URW6	Myosin-14	ISS	89264452	PubMed	PTHR13140:SF462	MYOSIN-14
P00010	B cell activation	P00391	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000001789|UniProtKB=F7GIU0	5-hydroxytryptamine receptor 1A	ISS	2156831	PubMed	PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P00018	EGF receptor signaling pathway	P00547	PP2A	DICPU|Gene=DICPUDRAFT_91511|UniProtKB=F0ZDJ1	Serine/threonine-protein phosphatase	ISS	99379588	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P02766	Phenylethylamine degradation	P03103	Phenylethylamine oxidase	HUMAN|HGNC=550|UniProtKB=Q16853	Membrane primary amine oxidase	ISS			PTHR10638:SF23	MEMBRANE PRIMARY AMINE OXIDASE
P00029	Huntington disease	P00778	NMDA receptor	CANLF|Gene=GRIN1|UniProtKB=Q5R1P0	Glutamate receptor ionotropic, NMDA 1	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	CANLF|Ensembl=ENSCAFG00000009203|UniProtKB=F1PVZ1	Muscarinic acetylcholine receptor	ISS	8100450	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00006	Apoptosis signaling pathway	P00310	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	TAKRU|Ensembl=ENSTRUG00000015413|UniProtKB=H2UR30	Uncharacterized protein	ISS			PTHR11681:SF13	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ORYSJ|EnsemblGenome=OS03G0836000|UniProtKB=Q10AZ4	Actin-3	IC	10974003	PubMed	PTHR11937:SF254	ACTIN-1-RELATED
P00034	Integrin signalling pathway	P00907	ERK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS			PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00629	PP2A	SCHMA|EnsemblGenome=Smp_165490|UniProtKB=C1LZY9	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P02748	Isoleucine biosynthesis	P02995	Threonine dehydratase	ECOLI|EcoGene=EG10990|UniProtKB=P0AGF6	L-threonine dehydratase catabolic TdcB	ISS			PTHR43419:SF8	THREONINE AMMONIA-LYASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00470	F-actin	HUMAN|HGNC=130|UniProtKB=P62736	Actin, aortic smooth muscle	IC	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CANLF|Ensembl=ENSCAFG00000032632|UniProtKB=J9P2Q5	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P04393	Ras Pathway	P04570	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00557	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	IGI	96009592	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CANAL|CGD=CAL0064759|UniProtKB=Q5AKX0	Uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00006	Apoptosis signaling pathway	P00260	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00048	PI3 kinase pathway	P01199	Galpha	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00238	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT2G43790|UniProtKB=Q39026	Mitogen-activated protein kinase 6	ISS	11707292	PubMed	PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P00018	EGF receptor signaling pathway	P00551	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01286	TGFbeta	CAEEL|WormBase=WBGene00003555|UniProtKB=Q20176	Zinc metalloproteinase nas-39	TAS	9759503	PubMed	PTHR43978:SF2	DORSAL-VENTRAL PATTERNING PROTEIN TOLLOID-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00632	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	HUMAN|HGNC=4587|UniProtKB=Q14957	Glutamate receptor ionotropic, NMDA 2C	IC	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00005	Angiogenesis	P00256	PLC-gamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00057	Wnt signaling pathway	P01457	GBeta	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IDA	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00045	Notch signaling pathway	P01112	CoR	MACMU|Ensembl=ENSMMUG00000023107|UniProtKB=F7GMR8	Uncharacterized protein	ISS	10441327	PubMed	PTHR13992:SF21	NUCLEAR RECEPTOR COREPRESSOR 2
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	RAT|RGD=1309438|UniProtKB=P0C8E4	Mitogen-activated protein kinase kinase kinase 7	ISS	10683140	PubMed	PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P00004	Alzheimer disease-presenilin pathway	P00139	E-cadherin transmembrane fragment	HUMAN|HGNC=1748|UniProtKB=P12830	Cadherin-1	IDA	12834808	PubMed	PTHR24027:SF319	CADHERIN-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00025	Hedgehog signaling pathway	P00682	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00029	Huntington disease	P00790	beta-Tubulin	SCHMA|EnsemblGenome=Smp_079970|UniProtKB=G4VTA5	Putative tubulin beta chain	ISS	9454836	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00057	Wnt signaling pathway	P01428	Frizzled	XENTR|Xenbase=XB-GENE-480800|UniProtKB=F6VM33	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF90	FRIZZLED-8
P00005	Angiogenesis	P00189	Fzd	DROME|FlyBase=FBgn0027343|UniProtKB=O77438	Frizzled-3	ISS	8717036	PubMed	PTHR11309:SF125	FRIZZLED-3
P04397	p53 pathway by glucose deprivation	P04636	S6K	CANLF|Ensembl=ENSCAFG00000011590|UniProtKB=E2R7K9	Ribosomal protein S6 kinase	ISS	15116068	PubMed	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00034	Integrin signalling pathway	P00937	Vinculin	DROME|FlyBase=FBgn0004397|UniProtKB=O46037	Vinculin	IPI	14702644	PubMed	PTHR18914:SF1	VINCULIN
P00021	FGF signaling pathway	P00644	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MOUSE|MGI=MGI=1339710|UniProtKB=G3UW82	MCG140437, isoform CRA_d	IEP	10938134	PubMed	PTHR13140:SF385	MYOSIN-2
P00052	TGF-beta signaling pathway	P01288	FKBP12	DANRE|ZFIN=ZDB-GENE-040927-9|UniProtKB=F1R3A6	Peptidyl-prolyl cis-trans isomerase	ISS			PTHR10516:SF341	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	MACMU|Ensembl=ENSMMUG00000019112|UniProtKB=F6T8S6	N-methyl D-aspartate receptor subtype 2B	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DROME|FlyBase=FBgn0000045|UniProtKB=P02574	Actin, larval muscle	ISS	10974003	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P05917	Opioid proopiomelanocortin pathway	P06006	beta-Endorphin	HUMAN|HGNC=9201|UniProtKB=P01189	Pro-opiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00049	Parkinson disease	P01236	Casein kinase II	SCHPO|PomBase=SPAC1851.03|UniProtKB=P40232	Casein kinase II subunit beta	IDA	10806215	PubMed	PTHR11740:SF13	CASEIN KINASE II SUBUNIT BETA'
P00018	EGF receptor signaling pathway	P00549	EGF	MACMU|Ensembl=ENSMMUG00000020882|UniProtKB=F7GSZ7	Uncharacterized protein	RCA			PTHR11100:SF20	PRO-NEUREGULIN-2, MEMBRANE-BOUND ISOFORM-RELATED
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00203	Erk	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00225	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	RCA			PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00005	Angiogenesis	P00254	GTPase	RAT|RGD=1304965|UniProtKB=A0A0G2K6E0	Protein Rhoc	ISS	14871999	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00021	FGF signaling pathway	P00628	JNK1-3	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	ISS			PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	BOVIN|Gene=CACNB1|UniProtKB=Q9MZL7	Voltage-dependent L-type calcium channel subunit beta-1	IC	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00010	B cell activation	P00382	Syk	MOUSE|MGI=MGI=99515|UniProtKB=P48025	Tyrosine-protein kinase SYK	IGI	8137818	PubMed	PTHR24418:SF231	TYROSINE-PROTEIN KINASE SYK
P00005	Angiogenesis	P00251	cPLA2	DANRE|ZFIN=ZDB-GENE-990415-45|UniProtKB=P50392	Cytosolic phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	PANTR|Ensembl=ENSPTRG00000017549|UniProtKB=H2QS18	Dopamine receptor D1	ISS	11861492	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00005	Angiogenesis	P00204	PLD	MACMU|Ensembl=ENSMMUG00000005666|UniProtKB=F6VWY6	Uncharacterized protein	ISS	9538008	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Gene=DRD2|UniProtKB=P20288	D(2) dopamine receptor	IDA	2039532	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00036	Interleukin signaling pathway	P00968	Ikk	MOUSE|MGI=MGI=99484|UniProtKB=Q60680	Inhibitor of nuclear factor kappa-B kinase subunit alpha	ISS	12813046	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00944	Actin	XENTR|Xenbase=XB-GENE-490883|UniProtKB=Q6NVA9	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04392	P53 pathway feedback loops 1	P04536	Mdm2	RAT|RGD=1305332|UniProtKB=A0A0G2JVC1	Protein Mdm2	ISS	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	ARATH|TAIR=AT1G02500|UniProtKB=P23686	S-adenosylmethionine synthase 1	ISS			PTHR11964:SF21	S-ADENOSYLMETHIONINE SYNTHASE 1-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00036	Interleukin signaling pathway	P00970	Interleukin	RAT|RGD=2887|UniProtKB=P97604	Interleukin-15	IC			PTHR45114:SF1	INTERLEUKIN-15
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P06587	Nicotine pharmacodynamics pathway	P06608	DDC	MACMU|Ensembl=ENSMMUG00000019991|UniProtKB=F7FNW0	Aromatic-L-amino-acid decarboxylase	ISS	7567987	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00049	Parkinson disease	P01236	Casein kinase II	SCHPO|PomBase=SPBC2G5.02c|UniProtKB=O94281	Probable casein kinase II subunit beta-2	IDA	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00560	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	CANAL|CGD=CAL0000192612|UniProtKB=P0CY33	Cell division control protein 42 homolog	ISS	12932731	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00047	PDGF signaling pathway	P01150	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02738	De novo purine biosynthesis	P02901	Adenosuccinate lyase	BOVIN|Gene=ADSL|UniProtKB=A3KN12	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05923	beta-ARR2	HUMAN|HGNC=712|UniProtKB=P32121	Beta-arrestin-2	RCA	12464600	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	DROME|FlyBase=FBgn0011286|UniProtKB=Q24498	Ryanodine receptor	IC			PTHR13715:SF79	RYANODINE RECEPTOR
P00054	Toll receptor signaling pathway	P01369	MKK1	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00056	VEGF signaling pathway	P01417	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00029	Huntington disease	P00807	Actin	TAKRU|Ensembl=ENSTRUG00000005447|UniProtKB=P68142	Actin, cytoplasmic 1	IDA	14684598	PubMed	PTHR11937:SF354	SUBFAMILY NOT NAMED
P00049	Parkinson disease	P01238	14-3-3	DROME|FlyBase=FBgn0020238|UniProtKB=P92177	14-3-3 protein epsilon	IDA	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04393	Ras Pathway	P04552	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00807	Actin	IXOSC|EnsemblGenome=ISCW024111|UniProtKB=B7PBG2	Actin, putative (Fragment)	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01150	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00034	Integrin signalling pathway	P00951	Jnk	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IDA	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00006	Apoptosis signaling pathway	P00321	HSP70	ORYSJ|EnsemblGenome=OS03G0821100|UniProtKB=Q84TA1	Heat shock cognate 70 kDa protein 2, putative, expressed	ISS	12150907	PubMed	PTHR19375:SF327	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	SCHPO|PomBase=SPBC12D12.04c|UniProtKB=P36583	Protein kinase C-like 2	TAS	93259141	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	RCA			PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P06959	CCKR signaling map	P07116	Guanylate cyclase	HUMAN|HGNC=4689|UniProtKB=Q02846	Retinal guanylyl cyclase 1	RCA	21335096	PubMed	PTHR11920:SF228	RETINAL GUANYLYL CYCLASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05923	beta-ARR2	MACMU|Ensembl=ENSMMUG00000017654|UniProtKB=F6UI32	Beta-arrestin-2 isoform 1	ISS	4757780	gi	PTHR11792:SF20	BETA-ARRESTIN-2
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	ORNAN|Ensembl=ENSOANG00000001027|UniProtKB=F6QDY0	Phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00009	Axon guidance mediated by netrin	P00359	NFAT	RAT|RGD=1308692|UniProtKB=A0A0G2JTY4	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 (Predicted), isoform CRA_b	ISS	9462517	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	HUMAN|HGNC=4582|UniProtKB=Q16099	Glutamate receptor ionotropic, kainate 4	ISS	11319238	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	BOVIN|Ensembl=ENSBTAG00000013047|UniProtKB=E1BLE8	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00057	Wnt signaling pathway	P01452	NFAT	BOVIN|Ensembl=ENSBTAG00000018270|UniProtKB=F1MGR9	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	HUMAN|HGNC=3403|UniProtKB=P32856	Syntaxin-2	RCA			PTHR19957:SF36	SYNTAXIN-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	PANTR|Ensembl=ENSPTRG00000009039|UniProtKB=H2RCA1	C-C motif chemokine	ISS			PTHR12015:SF91	C-C MOTIF CHEMOKINE 3-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	RAT|RGD=3250|UniProtKB=P35465	Serine/threonine-protein kinase PAK 1	ISS	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P02752	Mannose metabolism	P03017	Mannose 6-P isomerase	HUMAN|HGNC=7216|UniProtKB=P34949	Mannose-6-phosphate isomerase	NAS	9525984	PubMed	PTHR10309:SF0	MANNOSE-6-PHOSPHATE ISOMERASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	HUMAN|HGNC=4242|UniProtKB=O94808	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2	ISS			PTHR10937:SF10	GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE  ISOMERIZING  2
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02757	O-antigen biosynthesis	P03045	dTDP-glucose 4,6-dehydratase	METAC|EnsemblGenome=MA_4460|UniProtKB=Q8THQ2	dTDP-glucose 4,6-dehydratase	ISS			PTHR43725:SF8	UDP-GLUCOSE 4-EPIMERASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DICDI|dictyBase=DDB_G0268744|UniProtKB=Q55EU6	Putative actin-23	IC	14684598	PubMed	PTHR11937:SF154	ACTIN-17-RELATED
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	IC	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00053	T cell activation	P01306	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IDA	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00036	Interleukin signaling pathway	P00968	Ikk	PANTR|Ensembl=ENSPTRG00000033948|UniProtKB=H2RBD4	Conserved helix-loop-helix ubiquitous kinase	ISS	12235208	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_126324|UniProtKB=C3XYC2	Putative uncharacterized protein	IDA	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00047	PDGF signaling pathway	P01153	GSK3	ARATH|TAIR=AT3G05840|UniProtKB=P43289	Shaggy-related protein kinase gamma	ISS	7529201	PubMed	PTHR24057:SF13	SHAGGY-RELATED PROTEIN KINASE ALPHA-RELATED
P00049	Parkinson disease	P01242	Casein kinase I	CAEBR|Gene=CBG09510|UniProtKB=A8X8Y1	Protein CBG09510	ISS	11437445	PubMed	PTHR11909:SF19	ASATOR, ISOFORM D
P00034	Integrin signalling pathway	P00912	Arp2/3	MOUSE|MGI=MGI=1915021|UniProtKB=Q9CPW4	Actin-related protein 2/3 complex subunit 5	ISS	12473693	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00018	EGF receptor signaling pathway	P00551	Akt	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	IGI	14526383	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	RCA	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P02752	Mannose metabolism	P03019	P-Mannose mutase	MOUSE|MGI=MGI=1859214|UniProtKB=Q9Z2M7	Phosphomannomutase 2	IEA	12477932	PubMed	PTHR10466:SF2	PHOSPHOMANNOMUTASE 2
P00020	FAS signaling pathway	P00608	Pro-Caspase3	PANTR|Ensembl=ENSPTRG00000016640|UniProtKB=Q5IS54	Caspase-3	ISS			PTHR10454:SF198	CASPASE-3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00057	Wnt signaling pathway	P01444	Wnt	MONDO|Ensembl=ENSMODG00000015364|UniProtKB=F6WHM2	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P00012	Cadherin signaling pathway	P00471	Cadherin	ANOGA|Gene=AgaP_AGAP007924|UniProtKB=Q7Q3K5	AGAP007924-PA (Fragment)	IDA	8120095	PubMed	PTHR24026:SF69	PROTOCADHERIN FAT 4
P00021	FGF signaling pathway	P00634	MEKK1-5	PANTR|Ensembl=ENSPTRG00000009518|UniProtKB=H2QDN0	Mitogen-activated protein kinase kinase kinase 3	ISS	9006902	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	MACMU|Ensembl=ENSMMUG00000014334|UniProtKB=F7CYY6	Uncharacterized protein	ISS	11861492	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	HUMAN|HGNC=7553|UniProtKB=P01106	Myc proto-oncogene protein	IEP	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00036	Interleukin signaling pathway	P00990	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00797	p53	PANTR|Ensembl=ENSPTRG00000008703|UniProtKB=H2QC53	Cellular tumor antigen p53	ISS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00005	Angiogenesis	P00225	MEK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS			PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00560	Raf-1	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS			PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00021	FGF signaling pathway	P00644	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IGI	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	BOVIN|Gene=CTNNA1|UniProtKB=Q3MHM6	Catenin alpha-1	ISS	10456847	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01275	P38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00056	VEGF signaling pathway	P01402	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	RCA			PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00057	Wnt signaling pathway	P01432	Beta-Catenin	HUMAN|HGNC=2514|UniProtKB=P35222	Catenin beta-1	IDA	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00029	Huntington disease	P00780	Microtubule	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g245773|UniProtKB=A7SJX9	Predicted protein	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00018	EGF receptor signaling pathway	P00558	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00008	Axon guidance mediated by Slit/Robo	P00342	Slit	ORNAN|Ensembl=ENSOANG00000006668|UniProtKB=F6WEP3	Uncharacterized protein	ISS	10432110	PubMed	PTHR24373:SF107	SLIT HOMOLOG 2 PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05731	GABA-B receptor II signaling	P05752	PKA	DICDI|dictyBase=DDB_G0283907|UniProtKB=P34099	cAMP-dependent protein kinase catalytic subunit	RCA	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	MACMU|Ensembl=ENSMMUG00000003957|UniProtKB=F6ZFI9	Rho-related GTP-binding protein RhoG	ISS			PTHR24072:SF158	RHO-RELATED GTP-BINDING PROTEIN RHOG
P00025	Hedgehog signaling pathway	P00682	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IC	10395542	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P02741	Flavin biosynthesis	P02940	Riboflavin synthase	NEUCR|EnsemblGenome=EFNCRG00000007448|UniProtKB=Q7SD50	Riboflavin synthase subunit alpha	ISS			PTHR21098:SF0	RIBOFLAVIN SYNTHASE
P00029	Huntington disease	P00785	Cytochrome c	ORYSJ|EnsemblGenome=OS05G0301700|UniProtKB=Q0DJC3	Os05g0301700 protein	IDA	9027315	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	HUMAN|HGNC=144|UniProtKB=P63261	Actin, cytoplasmic 2	IC	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P02775	Salvage pyrimidine ribonucleotides	P03156	CDP kinase	RAT|RGD=1308313|UniProtKB=B5DF24	Uridine-cytidine kinase	ISS			PTHR10285:SF66	URIDINE-CYTIDINE KINASE 1
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	HUMAN|HGNC=4341|UniProtKB=P15104	Glutamine synthetase	ISS			PTHR20852:SF45	GLUTAMINE SYNTHETASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00046	Oxidative stress response	P01135	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	TAS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00906	Rap1	PANTR|Ensembl=ENSPTRG00000001102|UniProtKB=H2QZR9	RAP1A, member of RAS oncogene family	ISS	10476970	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00036	Interleukin signaling pathway	P00970	Interleukin	PANTR|Ensembl=ENSPTRG00000016467|UniProtKB=H2QQ76	Interleukin	ISS	7568001	PubMed	PTHR45114:SF1	INTERLEUKIN-15
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	BOVIN|Gene=DHFR|UniProtKB=P00376	Dihydrofolate reductase	ISS			PTHR22778:SF16	DIHYDROFOLATE REDUCTASE
P00020	FAS signaling pathway	P00602	DAXX	MACMU|Ensembl=ENSMMUG00000004287|UniProtKB=F6ZLZ0	Uncharacterized protein	ISS	10698492	PubMed	PTHR12766:SF7	DEATH DOMAIN-ASSOCIATED PROTEIN 6
P00034	Integrin signalling pathway	P00936	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IPI	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	PANTR|Ensembl=ENSPTRG00000006890|UniProtKB=H2Q943	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	CAEEL|WormBase=WBGene00019246|UniProtKB=Q9N5K2	DNA-directed RNA polymerases I, II, and III subunit RPABC1	ISS	11313498	gi	PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P00056	VEGF signaling pathway	P01414	PLC-gamma	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00005	Angiogenesis	P00219	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	HUMAN|HGNC=4579|UniProtKB=P39086	Glutamate receptor ionotropic, kainate 1	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	HUMAN|HGNC=290|UniProtKB=P35626	Beta-adrenergic receptor kinase 2	IDA	10852916	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	ANOGA|EnsemblGenome=AGAP001394|UniProtKB=F5HMS4	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	TAS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	RCA	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05916	Opioid prodynorphin pathway	P06002	G-protein	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IDA	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01419	Ets	BOVIN|Ensembl=ENSBTAG00000002341|UniProtKB=A5PJG9	ETS1 protein	ISS	15699632	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00589	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=11438|UniProtKB=Q13277	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00056	VEGF signaling pathway	P01423	p38MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00019	Endothelin signaling pathway	P00590	IP3 R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00147	TACE	RAT|RGD=620404|UniProtKB=Q9Z1K9	Disintegrin and metalloproteinase domain-containing protein 17	TAS	9774383	PubMed	PTHR11905:SF171	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IDA	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00018	EGF receptor signaling pathway	P00564	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12912997	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00029	Huntington disease	P00807	Actin	CHICK|Gene=ACTG2|UniProtKB=P63270	Actin, gamma-enteric smooth muscle	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00626	Spry	BOVIN|Ensembl=ENSBTAG00000008250|UniProtKB=A2VDU1	Protein sprouty homolog 4	ISS	12027893	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	RCA	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01138	MKK4	MACMU|Ensembl=ENSMMUG00000019842|UniProtKB=F7FU91	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CANLF|Ensembl=ENSCAFG00000015118|UniProtKB=F1PT61	Myosin-16	ISS			PTHR13140:SF438	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01162	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00047	PDGF signaling pathway	P01175	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	10982827	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01275	P38	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00006	Apoptosis signaling pathway	P00318	PKCs	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04392	P53 pathway feedback loops 1	G04682	MDM-2	PANTR|Ensembl=ENSPTRG00000005203|UniProtKB=H2R792	Mdm2 p53 binding protein homolog	ISS	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=12787|UniProtKB=P56706	Protein Wnt-7b	TAS	11266476	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00047	PDGF signaling pathway	P01143	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	TAS	22084520	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01192	p110	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00274	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00049	Parkinson disease	P01227	20S proteasome	ARATH|TAIR=AT1G56450|UniProtKB=Q7DLR9	Proteasome subunit beta type-4	TAS	12859888	PubMed	PTHR11599:SF5	PROTEASOME SUBUNIT BETA TYPE-4
P00049	Parkinson disease	P01213	Cyclin E	RAT|RGD=2294|UniProtKB=P39949	G1/S-specific cyclin-E1	IDA	6671698	gi	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	CHICK|Ensembl=ENSGALG00000002098|UniProtKB=F1P0L4	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00021	FGF signaling pathway	P00623	FGF	HUMAN|HGNC=3670|UniProtKB=Q92913	Fibroblast growth factor 13	IGI	12496262	PubMed	PTHR11486:SF77	FIBROBLAST GROWTH FACTOR 13
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	MOUSE|MGI=MGI=95818|UniProtKB=Q61626	Glutamate receptor ionotropic, kainate 5	ISS	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	HUMAN|HGNC=4588|UniProtKB=O15399	Glutamate receptor ionotropic, NMDA 2D	IC	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=30035|UniProtKB=Q8WYR1	Phosphoinositide 3-kinase regulatory subunit 5	ISS	129387	gi	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	IC	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00036	Interleukin signaling pathway	P00967	c-fos	PANTR|Ensembl=ENSPTRG00000006553|UniProtKB=A5A6H0	C-fos	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00005	Angiogenesis	P00223	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04623	CBP	BOVIN|Ensembl=ENSBTAG00000016198|UniProtKB=E1B8D6	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00048	PI3 kinase pathway	P01205	NOS	MACMU|Ensembl=ENSMMUG00000020437|UniProtKB=F6WEB2	Nitric oxide synthase	ISS	93055452	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00752	cGMP-gated ion channel	BOVIN|Ensembl=ENSBTAG00000002205|UniProtKB=Q00194	cGMP-gated cation channel alpha-1	IDA	12432397	PubMed	PTHR10217:SF387	CYCLIC NUCLEOTIDE-GATED CHANNEL ROD PHOTORECEPTOR SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02777	Succinate to proprionate conversion	P03161	Methylmalonyl-CoA mutase	DEIRA|EnsemblGenome=DR_1084|UniProtKB=Q9RVE5	Methylmalonyl-CoA mutase	ISS			PTHR42710:SF1	METHYLMALONYL-COA MUTASE, MITOCHONDRIAL
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	HUMAN|HGNC=11430|UniProtKB=Q86Y82	Syntaxin-12	IC	10321247	PubMed	PTHR19957:SF88	SYNTAXIN-12
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00009	Axon guidance mediated by netrin	P00366	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00021	FGF signaling pathway	P00633	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IGI	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00018	EGF receptor signaling pathway	P00552	Ras	CAEEL|WormBase=WBGene00002335|UniProtKB=P22981	Ras protein let-60	IGI	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00047	PDGF signaling pathway	P01164	PDK1/2	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	ISS	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00055	Transcription regulation by bZIP transcription factor	P01398	TFIIEalpha	RAT|RGD=1306851|UniProtKB=G3V992	General transcription factor II E, polypeptide 1 (Alpha subunit)	ISS	189964	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P02738	De novo purine biosynthesis	P02894	IMP cyclohydrolase	STRCO|EnsemblGenome=CAB92677|UniProtKB=Q9KY50	Bifunctional purine biosynthesis protein PurH	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P00049	Parkinson disease	P01227	20S proteasome	ANOGA|EnsemblGenome=AGAP004960|UniProtKB=Q7PPI7	Proteasome subunit alpha type	TAS	12859888	PubMed	PTHR11599:SF13	PROTEASOME SUBUNIT ALPHA TYPE-4
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	DANRE|ZFIN=ZDB-GENE-030407-1|UniProtKB=F1QC27	Uncharacterized protein	ISS			PTHR11681:SF14	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000022513|UniProtKB=F6YNZ0	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00051	TCA cycle	P01273	Succinate Dehydrogenase	SULSO|EnsemblGenome=SSO2357|UniProtKB=Q97W78	Succinate dehydrogenase subunit B (SdhB)	ISS	15899115	gi	PTHR43551:SF2	FUMARATE REDUCTASE IRON-SULFUR SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	XENTR|Xenbase=XB-GENE-961282|UniProtKB=Q6DF43	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P05915	Opioid proenkephalin pathway	P05994	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00036	Interleukin signaling pathway	P00973	PKB	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04395	Vasopressin synthesis	P04599	Amidating Enzyme	CAEEL|WormBase=WBGene00020556|UniProtKB=P83388	Probable peptidyl-glycine alpha-amidating monooxygenase pamn-1	IC	3153462	PubMed	PTHR10680:SF14	PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE
P00010	B cell activation	P00391	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	TAS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	PANTR|Ensembl=ENSPTRG00000011307|UniProtKB=H2QGV8	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF245	RAS-RELATED PROTEIN R-RAS
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02732	Coenzyme A linked carnitine metabolism	P02864	L-carnitine dehydratase	SULSO|EnsemblGenome=SSO3144|UniProtKB=Q97U79	Carnitine dehydratase, putative	ISS			PTHR43949:SF6	SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00965	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MACMU|Ensembl=ENSMMUG00000011427|UniProtKB=F6YXV7	Syntaxin-10	ISS	10839363	PubMed	PTHR19957:SF106	SYNTAXIN-10
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	DANRE|ZFIN=ZDB-GENE-030131-7595|UniProtKB=Q6PBR4	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00010	B cell activation	P00383	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00702	CPB	CHICK|Ensembl=ENSGALG00000008494|UniProtKB=Q7SX83	CAMP response element-binding protein	ISS			PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00029	Huntington disease	P00811	Arp2/3 complex	ARATH|TAIR=AT2G30910|UniProtKB=O80856	Actin-related protein 2/3 complex subunit 1A	TAS	12932731	PubMed	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05731	GABA-B receptor II signaling	P05755	Gbeta	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P05918	p38 MAPK pathway	P06027	CREB	MONDO|Ensembl=ENSMODG00000015970|UniProtKB=F7FD05	Uncharacterized protein	ISS	11390664	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00036	Interleukin signaling pathway	P00975	RasGAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00046	Oxidative stress response	P01135	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	TAS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00899	IRS 1-4	HUMAN|HGNC=6125|UniProtKB=P35568	Insulin receptor substrate 1	TAS	1311924	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01448	CBP	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	IDA	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00010	B cell activation	P00398	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IGI	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00029	Huntington disease	P00780	Microtubule	SCHPO|PomBase=SPBC26H8.07c|UniProtKB=P05219	Tubulin beta chain	IDA	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	RAT|RGD=2641|UniProtKB=Q62844	Tyrosine-protein kinase Fyn	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	TAKRU|Ensembl=ENSTRUG00000008289|UniProtKB=H2T7U8	Uncharacterized protein	ISS			PTHR24072:SF129	CDC42L PROTEIN
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	22533439	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00010	B cell activation	P00371	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	MACMU|Ensembl=ENSMMUG00000017022|UniProtKB=F7HQZ9	Uncharacterized protein	ISS	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00045	Notch signaling pathway	P01117	Neuralized	MOUSE|MGI=MGI=1334263|UniProtKB=Q923S6	E3 ubiquitin-protein ligase NEURL1	RCA			PTHR12429:SF13	E3 UBIQUITIN-PROTEIN LIGASE NEURL1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00029	Huntington disease	P00799	JNK-2	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00059	p53 pathway	P04609	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04393	Ras Pathway	P04560	AP1	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	3136397	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	G04671	proopiomelanocortin	MOUSE|MGI=MGI=97742|UniProtKB=P01193	Pro-opiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00049	Parkinson disease	P01230	Src kinase	MACMU|Ensembl=ENSMMUG00000017017|UniProtKB=F7FVL2	Tyrosine-protein kinase	ISS	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00019	Endothelin signaling pathway	P00566	ERK	YEAST|SGD=S000003272|UniProtKB=P14681	Mitogen-activated protein kinase KSS1	ISS			PTHR24055:SF338	MITOGEN-ACTIVATED PROTEIN KINASE KSS1
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00019	Endothelin signaling pathway	P00570	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	14744463	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	BOVIN|Ensembl=ENSBTAG00000044059|UniProtKB=F1MF20	Uncharacterized protein	ISS			PTHR18945:SF768	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-10
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00778	NMDA receptor	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00045	Notch signaling pathway	P01112	CoR	CANLF|Ensembl=ENSCAFG00000006985|UniProtKB=F1PQQ7	Uncharacterized protein	ISS	10441327	PubMed	PTHR13992:SF21	NUCLEAR RECEPTOR COREPRESSOR 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IC	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	TAS	22246731	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	DANRE|ZFIN=ZDB-GENE-051202-2|UniProtKB=Q6ZM67	Uncharacterized protein	ISS	11319238	PubMed	PTHR44391:SF3	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01465	Ggamma	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	DANRE|ZFIN=ZDB-GENE-030616-53|UniProtKB=Q71E60	AMPA receptor subunit GluR3B	ISS	12871085	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P02723	Adenine and hypoxanthine salvage pathway	P02810	Adenine phosphoribosyl transferase	DROME|FlyBase=FBgn0000109|UniProtKB=P12426	Adenine phosphoribosyltransferase	ISS			PTHR32315:SF3	ADENINE PHOSPHORIBOSYLTRANSFERASE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	PANTR|Ensembl=ENSPTRG00000004718|UniProtKB=H2Q5I0	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	10514528	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00012	Cadherin signaling pathway	P00474	Wnt	CHICK|Ensembl=ENSGALG00000005401|UniProtKB=Q3L251	Protein Wnt	IDA	8717036	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	HUMAN|HGNC=10897|UniProtKB=P12757	Ski-like protein	IGI	10485843	PubMed	PTHR10005:SF3	SKI-LIKE PROTEIN
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	BOVIN|Ensembl=ENSBTAG00000004775|UniProtKB=F1MBY1	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MONDO|Ensembl=ENSMODG00000018065|UniProtKB=F7G485	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	ANOGA|EnsemblGenome=AGAP010957|UniProtKB=Q7QGY7	AGAP010957-PA (Fragment)	ISS	3885394	PubMed	PTHR23050:SF245	AT16150P-RELATED
P05916	Opioid prodynorphin pathway	P05999	provasopressin	TAKRU|Ensembl=ENSTRUG00000015413|UniProtKB=H2UR30	Uncharacterized protein	ISS			PTHR11681:SF13	SUBFAMILY NOT NAMED
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MACMU|Ensembl=ENSMMUG00000017431|UniProtKB=F7HPP3	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00036	Interleukin signaling pathway	P00990	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01142	p90RSK	MOUSE|MGI=MGI=104557|UniProtKB=P18654	Ribosomal protein S6 kinase alpha-3	ISS	2779569	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00034	Integrin signalling pathway	P00916	Ras	PANTR|Ensembl=ENSPTRG00000034469|UniProtKB=H2Q2V0	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00018	EGF receptor signaling pathway	P00543	ERK1-2	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	IGI	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	TAS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00559	MEK1-2	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DROME|FlyBase=FBgn0024980|UniProtKB=Q7KVY7	Syntaxin-4	IC			PTHR19957:SF19	SYNTAXIN-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	ISS	14744463	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CAEEL|WormBase=WBGene00006371|UniProtKB=Q20024	Putative syntaxin-3	IC			PTHR19957:SF41	SYNTAXIN-1A
P00005	Angiogenesis	P00223	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00053	T cell activation	P01316	MHC-antigen	MOUSE|MGI=MGI=88127|UniProtKB=P01887	Beta-2-microglobulin	IPI			PTHR19944:SF62	BETA-2-MICROGLOBULIN
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	8327893	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00018	EGF receptor signaling pathway	P00543	ERK1-2	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IGI	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02920	dCTP deaminase	CHLTR|EnsemblGenome=CT_844|UniProtKB=O84851	tRNA-specific adenosine deaminase	ISS			PTHR11079:SF149	TRNA-SPECIFIC ADENOSINE DEAMINASE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000008503|UniProtKB=F6TGJ6	Uncharacterized protein	ISS	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00012	Cadherin signaling pathway	P00474	Wnt	CHICK|Ensembl=ENSGALG00000005396|UniProtKB=Q2LMP1	Protein Wnt-3a	IDA	11266476	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	CANLF|Ensembl=ENSCAFG00000017262|UniProtKB=F1PVV7	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF328	MYOSIN-10
P00053	T cell activation	P01327	Gads	MACMU|Ensembl=ENSMMUG00000004880|UniProtKB=F7AN37	GRB2-related adapter protein 2	ISS	51702266	gi	PTHR24418:SF299	GRB2-RELATED ADAPTER PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DICPU|Gene=DICPUDRAFT_90232|UniProtKB=F1A175	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00017	DNA replication	P00534	PCNA	ORYSJ|EnsemblGenome=OS02G0805200|UniProtKB=P17070	Proliferating cell nuclear antigen	ISS	91146597	PubMed	PTHR11352:SF0	PROLIFERATING CELL NUCLEAR ANTIGEN
P00049	Parkinson disease	P01212	p38 MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CANLF|Ensembl=ENSCAFG00000015708|UniProtKB=F2Z4N0	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	MONDO|Ensembl=ENSMODG00000020977|UniProtKB=F6S5B1	Uncharacterized protein (Fragment)	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00036	Interleukin signaling pathway	P00967	c-fos	PANTR|Ensembl=ENSPTRG00000006553|UniProtKB=A5A6H0	C-fos	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00029	Huntington disease	P00780	Microtubule	PANTR|Ensembl=ENSPTRG00000023373|UniProtKB=G2HHT2	Tubulin beta-2C chain	ISS	9454836	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00053	T cell activation	P01316	MHC-antigen	BOVIN|Ensembl=ENSBTAG00000012330|UniProtKB=P01888	Beta-2-microglobulin	IPI			PTHR19944:SF62	BETA-2-MICROGLOBULIN
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	IDA	6466184	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	ENTHI|EnsemblGenome=EHI_181250|UniProtKB=C4M5Z7	Rho family GTPase	ISS			PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00025	Hedgehog signaling pathway	P00682	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04396	Vitamin D metabolism and pathway	P04603	1alpha-Hydroxylase	MACMU|Ensembl=ENSMMUG00000006758|UniProtKB=F7HD06	Sterol 26-hydroxylase, mitochondrial	ISS	11013342	PubMed	PTHR24291:SF6	STEROL 26-HYDROXYLASE, MITOCHONDRIAL
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MACMU|Ensembl=ENSMMUG00000014807|UniProtKB=F6W548	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	IC	176892	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00968	Ikk	BOVIN|Ensembl=ENSBTAG00000007591|UniProtKB=Q95KV1	Inhibitor of nuclear factor kappa-B kinase subunit alpha	ISS	9346484	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00924	Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	IPI	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00010	B cell activation	P00379	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	PANTR|Gene=FPR1|UniProtKB=P79241	fMet-Leu-Phe receptor (Fragment)	ISS	7305065	gi	PTHR24225:SF15	FMET-LEU-PHE RECEPTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	CHICK|Ensembl=ENSGALG00000007509|UniProtKB=F1NM72	Uncharacterized protein	ISS	87005246	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00057	Wnt signaling pathway	P01465	Ggamma	HUMAN|HGNC=19663|UniProtKB=Q9UBI6	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	ISS	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	IC	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00030	Hypoxia response via HIF activation	P00819	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00015	Circadian clock system	P00505	Cry	PANTR|Ensembl=ENSPTRG00000003537|UniProtKB=H2Q3H0	Uncharacterized protein	ISS	10217146	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02753	Methionine biosynthesis	P03026	O-Succinyl homoserine lyase	ORYSJ|EnsemblGenome=OS10G0399700|UniProtKB=Q94I39	Cys/Met metabolism PLP-dependent enzyme family protein, expressed	ISS			PTHR43379:SF3	SUBFAMILY NOT NAMED
P00012	Cadherin signaling pathway	P00467	alpha-catenin	DANRE|Ensembl=ENSDARG00000024785|UniProtKB=B7ZC77	Catenin alpha-2	ISS	1638632	PubMed	PTHR18914:SF29	CATENIN ALPHA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000005865|UniProtKB=G5E577	Uncharacterized protein	ISS	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00059	p53 pathway	P04616	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Gene=PCDHB7|UniProtKB=Q5DRC7	Protocadherin beta-7	ISS	8120095	PubMed	PTHR24028:SF69	PROTOCADHERIN BETA-7
P00047	PDGF signaling pathway	P01143	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01230	Src kinase	HUMAN|HGNC=2444|UniProtKB=P41240	Tyrosine-protein kinase CSK	IDA	11078745	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00003	Alzheimer disease-amyloid secretase pathway	P00107	kinesin	MACMU|Ensembl=ENSMMUG00000022520|UniProtKB=F6YHS7	Kinesin light chain 2 isoform 1	ISS	11740561	PubMed	PTHR19959:SF177	KINESIN LIGHT CHAIN 2
P00010	B cell activation	P00381	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	ARATH|TAIR=AT4G35780|UniProtKB=Q8RWL6	Serine/threonine-protein kinase STY17	ISS			PTHR44012:SF3	SERINE/THREONINE-PROTEIN KINASE STY17-RELATED
P00006	Apoptosis signaling pathway	P00260	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IDA	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00824	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IGI	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00049	Parkinson disease	P01242	Casein kinase I	ARATH|TAIR=AT1G04440|UniProtKB=Q5XF24	At1g04440	IDA	11437445	PubMed	PTHR11909:SF178	CASEIN KINASE 1-LIKE PROTEIN 8
P00034	Integrin signalling pathway	P00922	Collagen	CHICK|Gene=COL12A1|UniProtKB=P13944	Collagen alpha-1(XII) chain	IDA	10778855	PubMed	PTHR45047:SF2	COLLAGEN ALPHA-1 XII  CHAIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P05913	Enkephalin release	P05972	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MOUSE|MGI=MGI=1309999|UniProtKB=Q922R0	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00056	VEGF signaling pathway	P01414	PLC-gamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00011	Blood coagulation	P00429	PN2	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00012	Cadherin signaling pathway	P00470	F-actin	TRYB2|Gene=Tb09.211.0620|UniProtKB=Q38E94	Actin A	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	RCA			PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ORYSJ|EnsemblGenome=OS05G0106600|UniProtKB=Q65XH8	Os05g0106600 protein	ISS	11889126	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	CAEEL|WormBase=WBGene00001745|UniProtKB=Q7KPV0	G protein, Subunit Alpha	IC			PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=69279|UniProtKB=Q9R0T4	Cadherin-1	IDA	11953314	PubMed	PTHR24027:SF319	CADHERIN-1
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	BOVIN|Ensembl=ENSBTAG00000018989|UniProtKB=A5D7D8	GRM3 protein	ISS	20012997	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	14526383	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00019	Endothelin signaling pathway	P00572	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IDA	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00010	B cell activation	P00386	Calcineurin	MOUSE|MGI=MGI=107164|UniProtKB=P63328	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	ISS	12091710	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00021	FGF signaling pathway	P00633	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04398	p53 pathway feedback loops 2	P04653	cdk2	HUMAN|HGNC=1771|UniProtKB=P24941	Cyclin-dependent kinase 2	ISS	15660127	PubMed	PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P00049	Parkinson disease	P01227	20S proteasome	PANTR|Ensembl=ENSPTRG00000007345|UniProtKB=H2Q9W6	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF13	PROTEASOME SUBUNIT ALPHA TYPE-4
P00018	EGF receptor signaling pathway	P00560	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04572	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02728	Arginine biosynthesis	P02847	N-actetylornithine deacetylase	CAEEL|WormBase=WBGene00016657|UniProtKB=Q18621	Uncharacterized protein	ISS			PTHR43808:SF8	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	PANTR|Ensembl=ENSPTRG00000009002|UniProtKB=H2QCN5	C-C motif chemokine	ISS			PTHR12015:SF144	C-C MOTIF CHEMOKINE 8
P00056	VEGF signaling pathway	P01402	MEK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS			PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	BOVIN|Ensembl=ENSBTAG00000011082|UniProtKB=P07455	Insulin-like growth factor I	ISS			PTHR11454:SF4	INSULIN-LIKE GROWTH FACTOR I
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00021	FGF signaling pathway	P00623	FGF	MOUSE|MGI=MGI=1914362|UniProtKB=Q9ESS2	Fibroblast growth factor 22	IGI	12837279	PubMed	PTHR11486:SF41	FIBROBLAST GROWTH FACTOR 22
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=15813|UniProtKB=Q9BZA8	Protocadherin-11 Y-linked	IDA	8120095	PubMed	PTHR43912:SF1	PROTOCADHERIN-11 X-LINKED-RELATED
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00539	14-3-3	ORNAN|Ensembl=ENSOANG00000003572|UniProtKB=F7DGH9	Uncharacterized protein	ISS	14593000	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00059	p53 pathway	G04694	p110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01200	SHIP	MACMU|Ensembl=ENSMMUG00000010451|UniProtKB=F7CRA7	Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2	ISS	10610720	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00034	Integrin signalling pathway	P00932	FAK	CHICK|Ensembl=ENSGALG00000016171|UniProtKB=Q00944	Focal adhesion kinase 1	IPI	9182576	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	IDA	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P06216	SCW signaling pathway	P06323	MED	DROME|FlyBase=FBgn0011655|UniProtKB=O62609	Mothers against decapentaplegic homolog	IEA	http://flybase.org/reports/FBgn0011655.html	Website	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P00020	FAS signaling pathway	P00615	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	TAS	10207617	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00005	Angiogenesis	P00254	GTPase	BOVIN|Ensembl=ENSBTAG00000004279|UniProtKB=P61585	Transforming protein RhoA	ISS	12039949	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04371	5-Hydroxytryptamine biosynthesis	P04400	Aromatic L-amino acid decarboxylase	MOUSE|MGI=MGI=94876|UniProtKB=O88533	Aromatic-L-amino-acid decarboxylase	IEA	90339966	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P04392	P53 pathway feedback loops 1	G04682	MDM-2	HUMAN|HGNC=6973|UniProtKB=Q00987	E3 ubiquitin-protein ligase Mdm2	IGI	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000009594|UniProtKB=G2HFH4	Somatostatin receptor type 2	ISS	12181435	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00052	TGF-beta signaling pathway	P01286	TGFbeta	DANRE|ZFIN=ZDB-GENE-040427-2|UniProtKB=Q8JFP9	Gdf11-like	ISS	9759503	PubMed	PTHR11848:SF230	GDF11-LIKE
P00048	PI3 kinase pathway	P01189	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00015	Circadian clock system	G01504	bmal1	RAT|RGD=62003|UniProtKB=Q9EPW1	Aryl hydrocarbon receptor nuclear translocator-like protein 1	IDA	11163178	PubMed	PTHR23042:SF52	ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 1
P00034	Integrin signalling pathway	P00948	Rho	XENTR|Xenbase=XB-GENE-941426|UniProtKB=Q28HZ4	Novel Rho protein	ISS	11360179	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00029	Huntington disease	P00780	Microtubule	PHYPA|Gene=PHYPADRAFT_186458|UniProtKB=Q6TYR7	Beta-tubulin 1	ISS	12932731	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00007	Axon guidance mediated by semaphorins	P00340	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00029	Huntington disease	P00800	PolyQ Htt	CANLF|Ensembl=ENSCAFG00000014682|UniProtKB=F1P7Y7	Uncharacterized protein	ISS	7620118	PubMed	PTHR10170:SF10	HUNTINGTIN
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	DICDI|dictyBase=DDB_G0276019|UniProtKB=Q552M5	Ras guanine nucleotide exchange factor Y	ISS			PTHR23113:SF99	PROTEIN SON OF SEVENLESS
P00060	Ubiquitin proteasome pathway	P01491	E2	NEUCR|EnsemblGenome=EFNCRG00000009482|UniProtKB=P52493	Ubiquitin-conjugating enzyme E2 2	ISS			PTHR43898:SF1	UBIQUITIN-CONJUGATING ENZYME E2-17 KDA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	RCA			PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00036	Interleukin signaling pathway	P00990	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DICPU|Gene=DICPUDRAFT_93216|UniProtKB=F1A421	Guanine nucleotide-binding protein subunit beta	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00034	Integrin signalling pathway	P00911	B-Raf	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	IC	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	CAEEL|WormBase=WBGene00018620|UniProtKB=O44588	Uncharacterized protein	ISS	3755548	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00021	FGF signaling pathway	P00627	ERK1-2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02746	Heme biosynthesis	P02976	Protoporphyrinogen oxidase	PANTR|Ensembl=ENSPTRG00000001574|UniProtKB=H2Q0G1	Protoporphyrinogen oxidase	ISS			PTHR42923:SF3	PROTOPORPHYRINOGEN OXIDASE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00983	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01428	Frizzled	CANLF|Ensembl=ENSCAFG00000004399|UniProtKB=E2RIL8	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF23	FRIZZLED-4
P00029	Huntington disease	P00777	CBP	ARATH|TAIR=AT1G55970|UniProtKB=Q9LG11	Histone acetyltransferase HAC4	IDA	10769018	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02784	Tyrosine biosynthesis	P03213	Aromatic amino acid aminotransferase	ARATH|TAIR=AT5G36160|UniProtKB=Q9LVY1	Tyrosine aminotransferase	ISS			PTHR11751:SF368	TYROSINE AMINOTRANSFERASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00053	T cell activation	P01323	I kappa B	CANLF|Ensembl=ENSCAFG00000013418|UniProtKB=E2RML9	Uncharacterized protein	ISS	10811867	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	HUMAN|HGNC=4580|UniProtKB=Q13002	Glutamate receptor ionotropic, kainate 2	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00056	VEGF signaling pathway	P01414	PLC-gamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00057	Wnt signaling pathway	P01451	Galpha	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	PANTR|Ensembl=ENSPTRG00000009477|UniProtKB=H2QDK7	Ribosomal protein S6 kinase	ISS	11861821	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00054	Toll receptor signaling pathway	P01369	MKK1	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06739	MEK1/2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	RCA	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	CANLF|Gene=PSEN1|UniProtKB=Q6RH31	Presenilin-1	TAS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	CHICK|Ensembl=ENSGALG00000014033|UniProtKB=E1BTS2	Uncharacterized protein	ISS	99084794	PubMed	PTHR24070:SF186	GTPASE KRAS
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04393	Ras Pathway	P04570	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00053	T cell activation	P01306	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IC	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00018	EGF receptor signaling pathway	P00564	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	IPI	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DROME|FlyBase=FBgn0000045|UniProtKB=P02574	Actin, larval muscle	IC	11889126	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IDA	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00036	Interleukin signaling pathway	P00989	Ets	PANTR|Ensembl=ENSPTRG00000005351|UniProtKB=H2Q6Q0	Uncharacterized protein	ISS	8970723	PubMed	PTHR11849:SF17	TRANSCRIPTION FACTOR SPI-C
P02756	N-acetylglucosamine metabolism	P03043	N-acetylglucosamine-1-phosphate uridyltransferase	PSEAE|EnsemblGenome=PA5552|UniProtKB=Q9HT22	Bifunctional protein GlmU	ISS			PTHR43584:SF3	BIFUNCTIONAL PROTEIN GLMU
P05912	Dopamine receptor mediated signaling pathway	P05961	DOPA decarb.	MACMU|Ensembl=ENSMMUG00000019991|UniProtKB=F7FNW0	Aromatic-L-amino-acid decarboxylase	ISS	7567987	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	HUMAN|HGNC=18123|UniProtKB=Q8NER5	Activin receptor type-1C	TAS	10683140	PubMed	PTHR23255:SF58	ACTIVIN RECEPTOR TYPE-1C
P00005	Angiogenesis	P00182	p38MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	IXOSC|EnsemblGenome=ISCW014549|UniProtKB=B7QGY5	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	HUMAN|HGNC=1388|UniProtKB=O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	11976940	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	MONDO|Ensembl=ENSMODG00000001619|UniProtKB=F7ANI3	Uncharacterized protein	ISS	1370475	PubMed	PTHR44087:SF2	PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, LIVER/TESTIS ISOFORM
P00057	Wnt signaling pathway	P01456	beta-arrestin	BOVIN|Ensembl=ENSBTAG00000020485|UniProtKB=P17870	Beta-arrestin-1	IDA	11742073	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00771	Sin3A	CHICK|Ensembl=ENSGALG00000001644|UniProtKB=E1BX21	Uncharacterized protein	ISS	10441327	PubMed	PTHR12346:SF2	PAIRED AMPHIPATHIC HELIX PROTEIN SIN3A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	TAKRU|Ensembl=ENSTRUG00000010022|UniProtKB=H2TKL1	Actin-related protein 2/3 complex subunit 4	ISS	5031595	gi	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P05916	Opioid prodynorphin pathway	P06002	G-protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00049	Parkinson disease	P01234	GRK	MOUSE|MGI=MGI=87941|UniProtKB=Q3UYH7	Beta-adrenergic receptor kinase 2	ISS	8288567	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01087	CAT	PANTR|Ensembl=ENSPTRG00000002489|UniProtKB=H2RAF8	Uncharacterized protein	ISS	92155737	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00029	Huntington disease	P00807	Actin	MACMU|Ensembl=ENSMMUG00000009341|UniProtKB=F6UA54	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00058	mRNA splicing	P01473	U6	RAT|RGD=1310555|UniProtKB=A0A0G2JTI7	Protein Prpf3	ISS	9328476	PubMed	PTHR14212:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02743	Formyltetrahydroformate biosynthesis	P02953	Cobalamin dependent homocysteine transmethylase	CANLF|Ensembl=ENSCAFG00000010464|UniProtKB=E2R716	Uncharacterized protein	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	DANRE|ZFIN=ZDB-GENE-020125-4|UniProtKB=F1QKT1	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00036	Interleukin signaling pathway	P00976	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IDA	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05913	Enkephalin release	P05974	G-Protein (i)	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	IC	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04393	Ras Pathway	P04558	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00632	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00776	c-Jun	XENTR|Xenbase=XB-GENE-482228|UniProtKB=F6RYL1	Uncharacterized protein	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00013	Cell cycle	P00480	Proteasome	RAT|RGD=621109|UniProtKB=O88321	Antisecretory factor	ISS	13645506	gi	PTHR10223:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	YEAST|SGD=S000001295|UniProtKB=P07278	cAMP-dependent protein kinase regulatory subunit	IC	91298951	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01408	Akt/PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01210	UCH-L1	HUMAN|HGNC=12513|UniProtKB=P09936	Ubiquitin carboxyl-terminal hydrolase isozyme L1	ISS	12408865	PubMed	PTHR10589:SF19	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00003	Alzheimer disease-amyloid secretase pathway	P00094	BACE-1 pro-domain	BOVIN|Ensembl=ENSBTAG00000019365|UniProtKB=Q2HJ40	Beta-secretase 1	ISS	10531052	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MACMU|Ensembl=ENSMMUG00000000602|UniProtKB=F7C827	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF144	REGULATOR OF G-PROTEIN SIGNALING 11
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	CAEEL|WormBase=WBGene00004769|UniProtKB=P52166	Presenilin sel-12	TAS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00010	B cell activation	P00398	IP3R	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00060	Ubiquitin proteasome pathway	P01490	E3	PANTR|Ensembl=ENSPTRG00000015998|UniProtKB=G2HEI6	Ubiquitin-conjugating enzyme E2-25 kDa	ISS			PTHR44020:SF2	UBIQUITIN-CONJUGATING ENZYME E2 K
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	PANTR|Ensembl=ENSPTRG00000001757|UniProtKB=H2Q0Q8	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF147	REGULATOR OF G-PROTEIN SIGNALING 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	ISS	8643568	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=620023|UniProtKB=P10980	Muscarinic acetylcholine receptor M2	IDA	11166329	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	TAS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	PHYPA|Gene=PHYPADRAFT_233909|UniProtKB=A9SRU1	Predicted protein	ISS			PTHR23073:SF24	26S PROTEASE REGULATORY SUBUNIT 4
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IGI	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00010	B cell activation	P00386	Calcineurin	HUMAN|HGNC=9314|UniProtKB=Q08209	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	IDA	12015605	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00046	Oxidative stress response	P01129	JNK1/2	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00587	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00642	MEK1-2	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	DROME|FlyBase=FBgn0024326|UniProtKB=O61444	MAP kinase kinase 4, isoform A	IC	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	HUMAN|HGNC=4574|UniProtKB=P48058	Glutamate receptor 4	ISS	12871085	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00048	PI3 kinase pathway	P01188	Gbetagamma	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CHICK|Ensembl=ENSGALG00000011809|UniProtKB=F1NMB0	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00056	VEGF signaling pathway	P01407	Erk	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00780	Microtubule	ORNAN|Ensembl=ENSOANG00000004797|UniProtKB=F7FFR0	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P04398	p53 pathway feedback loops 2	P04668	p53	BOVIN|Ensembl=ENSBTAG00000001069|UniProtKB=P67939	Cellular tumor antigen p53	TAS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00048	PI3 kinase pathway	P01192	p110	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00015	Circadian clock system	P00502	Casein kinase I	ORNAN|Ensembl=ENSOANG00000010562|UniProtKB=F6TBG4	Uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00805	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00866	Cytokine receptor	MOUSE|MGI=MGI=109380|UniProtKB=Q61190	Interleukin-10 receptor subunit beta	IDA	98130620	PubMed	PTHR20859:SF50	INTERLEUKIN-10 RECEPTOR SUBUNIT BETA
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	ORNAN|Ensembl=ENSOANG00000011166|UniProtKB=F7D5G3	Phosphoinositide phospholipase C	ISS			PTHR10336:SF84	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2
P04395	Vasopressin synthesis	P04594	Neurophysin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IDA	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	ORNAN|Ensembl=ENSOANG00000000818|UniProtKB=F6PLI7	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00036	Interleukin signaling pathway	P00990	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00564	Rac	CHICK|Ensembl=ENSGALG00000005475|UniProtKB=Q5ZMG8	Uncharacterized protein	ISS			PTHR24072:SF150	RAS HOMOLOG GENE FAMILY, MEMBER GA-RELATED
P00047	PDGF signaling pathway	P01154	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P04395	Vasopressin synthesis	P04593	Glycopeptide	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	IC	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00030	Hypoxia response via HIF activation	P00819	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	TAS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00005	Angiogenesis	P00219	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS			PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00018	EGF receptor signaling pathway	P00564	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00006	Apoptosis signaling pathway	P00310	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00203	Erk	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04384	Gamma-aminobutyric acid synthesis	P04481	Succinic semialdehyde dehydrogenase	MOUSE|MGI=MGI=2441982|UniProtKB=Q8BWF0	Succinate-semialdehyde dehydrogenase, mitochondrial	IC	12891648	PubMed	PTHR43353:SF5	SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL
P04393	Ras Pathway	P04552	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	IGI	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00539	14-3-3	CHICK|Ensembl=ENSGALG00000004143|UniProtKB=Q5ZLQ6	14-3-3 protein beta/alpha	ISS	1671102	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00060	Ubiquitin proteasome pathway	P01491	E2	ORYSJ|EnsemblGenome=OS01G0839700|UniProtKB=Q943L1	Os01g0839700 protein	ISS			PTHR24067:SF3	UBIQUITIN-CONJUGATING ENZYME E2 G1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02749	Leucine biosynthesis	P03001	3-Isopropylmalate dehydrogenase	STRCO|EnsemblGenome=CAA19970|UniProtKB=O86504	3-isopropylmalate dehydrogenase	ISS			PTHR43275:SF1	D-MALATE DEHYDROGENASE  DECARBOXYLATING
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00018	EGF receptor signaling pathway	P00539	14-3-3	CHICK|Gene_ORFName=RCJMB04_5e12|UniProtKB=Q5F3W6	14-3-3 protein gamma	ISS	91108808	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00006	Apoptosis signaling pathway	P00257	Bcl-xL	MOUSE|MGI=MGI=88139|UniProtKB=Q64373	Bcl-2-like protein 1	ISS			PTHR11256:SF12	BCL-2-LIKE PROTEIN 1
P00045	Notch signaling pathway	P01113	Pen-2	CHICK|Gene=PSEN2|UniProtKB=Q90X07	Presenilin-2	ISS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02738	De novo purine biosynthesis	P02891	GDP kinase	BOVIN|Ensembl=ENSBTAG00000016552|UniProtKB=A5PK70	Nucleoside diphosphate kinase	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	HUMAN|HGNC=4597|UniProtKB=P41594	Metabotropic glutamate receptor 5	IDA	7476890	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00021	FGF signaling pathway	P00629	PP2A	CHICK|Ensembl=ENSGALG00000007565|UniProtKB=F1NS72	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B	ISS	9125135	PubMed	PTHR11871:SF1	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00717	Phosphorylase b	RAT|RGD=3461|UniProtKB=P09812	Glycogen phosphorylase, muscle form	IDA	4318782	PubMed	PTHR11468:SF13	GLYCOGEN PHOSPHORYLASE, MUSCLE FORM
P00034	Integrin signalling pathway	P00935	ILK	DANRE|ZFIN=ZDB-GENE-040426-1435|UniProtKB=Q6PHD6	Integrin linked kinase	ISS			PTHR44344:SF1	INTEGRIN-LINKED PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01465	Ggamma	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00021	FGF signaling pathway	P00645	Rac	MACMU|Ensembl=ENSMMUG00000021075|UniProtKB=F7GY91	Uncharacterized protein	ISS	11756405	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00019	Endothelin signaling pathway	P00574	Big ET1-4	MOUSE|MGI=MGI=95285|UniProtKB=P48299	Endothelin-3	IGI	9012511	PubMed	PTHR13874:SF11	ENDOTHELIN-3
P00053	T cell activation	P01312	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00634	MEKK1-5	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS	9079650	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00015	Circadian clock system	P00502	Casein kinase I	HUMAN|HGNC=2452|UniProtKB=P48730	Casein kinase I isoform delta	ISS	11437445	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MACMU|Ensembl=ENSMMUG00000007509|UniProtKB=F6QDX8	Uncharacterized protein	ISS			PTHR13140:SF273	UNCONVENTIONAL MYOSIN-VA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	BOVIN|Ensembl=ENSBTAG00000008783|UniProtKB=E1BD86	Uncharacterized protein	ISS	12181435	PubMed	PTHR24247:SF116	5-HYDROXYTRYPTAMINE RECEPTOR 7
P00036	Interleukin signaling pathway	P00965	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00053	T cell activation	P01311	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	8787761	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00254	GTPase	MONDO|Ensembl=ENSMODG00000012981|UniProtKB=F7CS91	Uncharacterized protein	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=12784|UniProtKB=P41221	Protein Wnt-5a	TAS	8717036	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00034	Integrin signalling pathway	P00936	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00790	beta-Tubulin	RAT|RGD=628596|UniProtKB=P69897	Tubulin beta-5 chain	ISS	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	CHICK|Gene_ORFName=RCJMB04_14g1|UniProtKB=Q5F3L1	Ribosomal protein S6 kinase alpha-5	ISS	9687510	PubMed	PTHR24351:SF115	RIBOSOMAL PROTEIN S6 KINASE ALPHA-5
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BRAFL|Gene=BRAFLDRAFT_118160|UniProtKB=C3Z2P0	Protein Wnt	TAS	11266476	PubMed	PTHR12027:SF77	PROTEIN WNT-5
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00012	Cadherin signaling pathway	P00475	Frizzled	CHICK|Gene=FZD1|UniProtKB=O57328	Frizzled-1	IDA	11212302	PubMed	PTHR11309:SF81	FRIZZLED-1
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	PLAF7|EnsemblGenome=PFD0830w|UniProtKB=Q8I1R6	Bifunctional dihydrofolate reductase-thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00055	Transcription regulation by bZIP transcription factor	P01395	TFIIE	MOUSE|MGI=MGI=1915403|UniProtKB=Q9D902	General transcription factor IIE subunit 2	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	PANTR|Ensembl=ENSPTRG00000014014|UniProtKB=H2QL58	Uncharacterized protein	ISS	10778855	PubMed	PTHR44172:SF1	COLLAGEN ALPHA-2 VI  CHAIN
P00005	Angiogenesis	P00203	Erk	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00623	FGF	RAT|RGD=620177|UniProtKB=Q8VI79	Fibroblast growth factor	ISS			PTHR11486:SF41	FIBROBLAST GROWTH FACTOR 22
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02746	Heme biosynthesis	P02974	Uroporphyrinogen-III synthase	HUMAN|HGNC=12592|UniProtKB=P10746	Uroporphyrinogen-III synthase	ISS			PTHR12390:SF0	UROPORPHYRINOGEN-III SYNTHASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00012	Cadherin signaling pathway	P00473	P120	BOVIN|Ensembl=ENSBTAG00000017222|UniProtKB=F1MM16	Uncharacterized protein	ISS			PTHR10372:SF9	CATENIN DELTA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MOUSE|MGI=MGI=104589|UniProtKB=P63268	Actin, gamma-enteric smooth muscle	IC	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00729	Goalpha	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-9966|UniProtKB=Q6TH03	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	11035810	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P02763	Peptidoglycan biosynthesis	P03090	N-Acetylglucosaminyl transferase	BACTN|EnsemblGenome=BT_3448|UniProtKB=Q8A258	UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase	ISS			PTHR21015:SF22	GLYCOSYLTRANSFERASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P06959	CCKR signaling map	P07090	MAPK8-10	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	RCA	8621433	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_127488|UniProtKB=C3XYC7	Putative uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00012	Cadherin signaling pathway	P00474	Wnt	XENTR|Xenbase=XB-GENE-960148|UniProtKB=F6XMD3	Protein Wnt (Fragment)	ISS	11266476	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MACMU|Ensembl=ENSMMUG00000022347|UniProtKB=F6ZCH5	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IPI	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MACMU|Ensembl=ENSMMUG00000017047|UniProtKB=F7HNS0	Uncharacterized protein	ISS	12356903	PubMed	PTHR11267:SF83	BRACHYURY PROTEIN
P00047	PDGF signaling pathway	P01161	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	G04714	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CHICK|Ensembl=ENSGALG00000001462|UniProtKB=F1NSB8	Adenosine receptor A3	IDA	11781138	PubMed	PTHR24246:SF2	ADENOSINE RECEPTOR A3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04393	Ras Pathway	P04558	p38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IDA	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	CHICK|Gene=CHRM3|UniProtKB=P49578	Muscarinic acetylcholine receptor M3	TAS	10069496	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00049	Parkinson disease	P01240	hSel10	MOUSE|MGI=MGI=1354695|UniProtKB=Q8VBV4	F-box/WD repeat-containing protein 7	RCA			PTHR44007:SF6	F-BOX/WD REPEAT-CONTAINING PROTEIN 7
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MACMU|Ensembl=ENSMMUG00000009600|UniProtKB=F7AC65	Uncharacterized protein	ISS	12623444	PubMed	PTHR11920:SF291	ADENYLATE CYCLASE TYPE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	PANTR|Ensembl=ENSPTRG00000012658|UniProtKB=H2QJ05	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF74	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=2685045|UniProtKB=E9QAN8	Protein Pik3c2b	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	IDA	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Ensembl=ENSPTRG00000011042|UniProtKB=H2QGF5	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00019	Endothelin signaling pathway	P00572	MEK	CAEEL|WormBase=WBGene00003186|UniProtKB=Q10664	Dual specificity mitogen-activated protein kinase kinase mek-2	IGI	17508425	gi	PTHR24361:SF629	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1
P00005	Angiogenesis	P00254	GTPase	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	ISS	12169092	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00034	Integrin signalling pathway	P00941	Integrin alpha	PANTR|Ensembl=ENSPTRG00000008042|UniProtKB=H2QB02	Uncharacterized protein	ISS	3487386	PubMed	PTHR23220:SF120	INTEGRIN ALPHA-M
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	MOUSE|MGI=MGI=99659|UniProtKB=E9PZQ0	Ryanodine receptor 1	ISS	8930069	PubMed	PTHR13715:SF15	RYANODINE RECEPTOR 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	XENTR|Xenbase=XB-GENE-480947|UniProtKB=F6ZM17	Uncharacterized protein (Fragment)	ISS	10558991	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	DROME|FlyBase=FBgn0015024|UniProtKB=P54367	Casein kinase I isoform alpha	IDA	11955435	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00024	Glycolysis	P00675	Pyruvate kinase	MOUSE|MGI=MGI=97604|UniProtKB=P53657	Pyruvate kinase PKLR	RCA			PTHR11817:SF31	PYRUVATE KINASE PKLR
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	CAEEL|WormBase=WBGene00004860|UniProtKB=Q09488	Serine/threonine-protein kinase sma-6	TAS	11252892	PubMed	PTHR23255:SF68	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Ensembl=ENSBTAG00000014674|UniProtKB=P41985	Muscarinic acetylcholine receptor M2	ISS	12181435	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P05730	Endogenous cannabinoid signaling	P05743	CB1	CHICK|Ensembl=ENSGALG00000015789|UniProtKB=F1NJC1	Uncharacterized protein	ISS	2165569	PubMed	PTHR22750:SF47	CANNABINOID RECEPTOR 1
P02724	Alanine biosynthesis	P02815	Branched chain amino acid aminotransferase	BOVIN|Ensembl=ENSBTAG00000013825|UniProtKB=A4IFQ7	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF51	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, CYTOSOLIC
P00020	FAS signaling pathway	P00601	c-Jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	XENTR|Xenbase=XB-GENE-1005304|UniProtKB=Q28HF5	Polymerase (RNA) II (DNA directed) polypeptide E	ISS			PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00034	Integrin signalling pathway	P00951	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00052	TGF-beta signaling pathway	P01286	TGFbeta	RAT|RGD=620104|UniProtKB=Q6HA10	Growth/differentiation factor 6	TAS	9759503	PubMed	PTHR11848:SF43	GROWTH/DIFFERENTIATION FACTOR 6
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IGI	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00253	Axin	PANTR|Ensembl=ENSPTRG00000009554|UniProtKB=H2QDP9	Uncharacterized protein	ISS	12356903	PubMed	PTHR10845:SF103	AXIN-2
P00001	Adrenaline and noradrenaline biosynthesis	P00066	DOPA decarb.	HUMAN|HGNC=2719|UniProtKB=P20711	Aromatic-L-amino-acid decarboxylase	ISS	7567987	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00045	Notch signaling pathway	P01114	Ntm	CANLF|Ensembl=ENSCAFG00000010476|UniProtKB=F1PS94	Uncharacterized protein	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P02747	Histidine biosynthesis	P02992	Imidazol glycerol phosphate synthase	RHOBA|EnsemblGenome=RB10112|UniProtKB=Q7UKJ9	Imidazole glycerol phosphate synthase subunit HisF	ISS			PTHR21235:SF2	IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF
P00035	Interferon-gamma signaling pathway	P00956	SOCS	HUMAN|HGNC=16852|UniProtKB=O75159	Suppressor of cytokine signaling 5	TAS	15032587	PubMed	PTHR44282:SF3	SUPPRESSOR OF CYTOKINE SIGNALING 5
P05730	Endogenous cannabinoid signaling	P05748	mGluR	MOUSE|MGI=MGI=1351342|UniProtKB=Q3UVX5	Metabotropic glutamate receptor 5	ISS	14614461	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00223	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00221	JNK1	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_114535|UniProtKB=C3ZHN2	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P06959	CCKR signaling map	P07090	MAPK8-10	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	RCA	20150185	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00057	Wnt signaling pathway	P01465	Ggamma	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	IC	88234494	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P05913	Enkephalin release	G06045	preproenkephalin	RAT|RGD=68946|UniProtKB=P04094	Proenkephalin-A	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	HUMAN|HGNC=7851|UniProtKB=Q13232	Nucleoside diphosphate kinase 3	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P00017	DNA replication	P00527	Histones	ARATH|TAIR=AT1G13370|UniProtKB=Q9FX60	Histone H3-like 1	ISS	12413958	PubMed	PTHR11426:SF178	HISTONE H3-LIKE 1-RELATED
P00054	Toll receptor signaling pathway	P01364	TPL2	MOUSE|MGI=MGI=1346878|UniProtKB=Q07174	Mitogen-activated protein kinase kinase kinase 8	ISS	99133929	PubMed	PTHR24361:SF94	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 8
P00021	FGF signaling pathway	P00644	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	ISS	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00053	T cell activation	P01305	Calmodulin	DANRE|Ensembl=ENSDARG00000015050|UniProtKB=Q6PI52	Calmodulin	ISS	3885394	PubMed	PTHR23050:SF326	CALMODULIN
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	MOUSE|MGI=MGI=2444087|UniProtKB=Q8JZR4	Excitatory amino acid transporter 5	ISS	94365697	PubMed	PTHR11958:SF22	EXCITATORY AMINO ACID TRANSPORTER 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00034	Integrin signalling pathway	P00922	Collagen	MACMU|Ensembl=ENSMMUG00000012031|UniProtKB=F7GWI9	Uncharacterized protein	ISS	10778855	PubMed	PTHR44057:SF3	COLLAGEN ALPHA-2 VIII  CHAIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	8687401	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00037	Ionotropic glutamate receptor pathway	P01020	NSF	XENTR|Ensembl=ENSXETG00000031364|UniProtKB=F6PIV9	Uncharacterized protein	ISS	7969419	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	BOVIN|Ensembl=ENSBTAG00000004775|UniProtKB=F1MBY1	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00046	Oxidative stress response	P01135	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00049	Parkinson disease	P01230	Src kinase	RAT|RGD=1308859|UniProtKB=Q4KM97	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF181	TYROSINE-PROTEIN KINASE BLK
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04393	Ras Pathway	P04557	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	IDA	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04393	Ras Pathway	P04547	Ras	CHICK|Ensembl=ENSGALG00000006885|UniProtKB=P08642	GTPase HRas	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00029	Huntington disease	P00807	Actin	PHYIT|EnsemblGenome=PITG_15117|UniProtKB=D0NRP9	Actin-like protein	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00053	T cell activation	P01324	rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12960248	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P02738	De novo purine biosynthesis	P02900	AICAR transformylase	DICDI|dictyBase=DDB_G0277087|UniProtKB=Q86L14	Bifunctional purine biosynthesis protein purH	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00053	T cell activation	P01330	IKK	RAT|RGD=1306661|UniProtKB=G3V926	Conserved helix-loop-helix ubiquitous kinase (Predicted)	ISS	9346484	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00010	B cell activation	P00383	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00029	Huntington disease	P00778	NMDA receptor	CAEEL|WormBase=WBGene00003774|UniProtKB=G5EGQ9	NMDA class glutamate Receptor	IDA	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	IDA	11035810	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=108071|UniProtKB=P70701	Protein Wnt-10a	IDA	11266476	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P02751	Lysine biosynthesis	P03006	Dihydrodipicolinate  reductase	ARATH|TAIR=AT3G59890|UniProtKB=Q8LB01	4-hydroxy-tetrahydrodipicolinate reductase 2, chloroplastic	ISS			PTHR20836:SF4	4-HYDROXY-TETRAHYDRODIPICOLINATE REDUCTASE 1, CHLOROPLASTIC-RELATED
P00017	DNA replication	P00527	Histones	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g159483|UniProtKB=A7RJG4	Predicted protein	ISS	12413958	PubMed	PTHR11426:SF169	HISTONE H3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-478663|UniProtKB=F7EG64	Protein kinase C delta type	ISS	11880265	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00018	EGF receptor signaling pathway	P00552	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00780	Microtubule	MOUSE|MGI=MGI=107814|UniProtKB=A2AQ07	Tubulin beta-1 chain	IDA	9454836	PubMed	PTHR11588:SF112	TUBULIN BETA-1 CHAIN
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MACMU|Ensembl=ENSMMUG00000011013|UniProtKB=F7GQW6	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF125	MATRIX METALLOPROTEINASE-20
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00047	PDGF signaling pathway	P01161	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00471	Cadherin	CANLF|Ensembl=ENSCAFG00000018996|UniProtKB=E2R858	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF290	CADHERIN-10
P00029	Huntington disease	P00811	Arp2/3 complex	YEAST|SGD=S000000438|UniProtKB=P38328	Actin-related protein 2/3 complex subunit 1	TAS	12932731	PubMed	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CANLF|Ensembl=ENSCAFG00000028654|UniProtKB=J9P702	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00010	B cell activation	P00383	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00786	ARF	MONDO|Ensembl=ENSMODG00000003056|UniProtKB=F6PNX7	Uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P00019	Endothelin signaling pathway	P00566	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00029	Huntington disease	P00774	Dynein complex	DROME|FlyBase=FBgn0013811|UniProtKB=Q7KVA7	Dynein heavy chain at 62B	IPI	9454836	PubMed	PTHR10676:SF255	DYNEIN HEAVY CHAIN 12, AXONEMAL
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	BRAFL|Gene=BRAFLDRAFT_122664|UniProtKB=C3ZIB9	Putative uncharacterized protein	ISS	4757952	gi	PTHR24072:SF192	CDC42 HOMOLOG
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00059	p53 pathway	P01486	Akt	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	TAS	95181376	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00247	Tie2	MOUSE|MGI=MGI=98664|UniProtKB=Q02858	Angiopoietin-1 receptor	ISS	1630810	PubMed	PTHR24416:SF125	ANGIOPOIETIN-1 RECEPTOR
P02738	De novo purine biosynthesis	P02909	GDP reductase	CAEEL|WormBase=WBGene00017610|UniProtKB=Q19599	Uncharacterized protein	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00029	Huntington disease	P00790	beta-Tubulin	DAPPU|EnsemblGenome=DAPPUDRAFT_302845|UniProtKB=E9GER1	Putative uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P02785	Valine biosynthesis	P03216	Acetolactate synthase	CHLRE|EnsemblGenome=CHLREDRAFT_138180|UniProtKB=A8J1U3	Acetolactate synthase, large subunit	ISS			PTHR18968:SF112	ACETOLACTATE SYNTHASE, CHLOROPLASTIC
P00018	EGF receptor signaling pathway	P00551	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000023202|UniProtKB=F7EU36	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	CANLF|Ensembl=ENSCAFG00000015905|UniProtKB=E2QUH6	Uncharacterized protein	ISS	12464600	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00015	Circadian clock system	P00505	Cry	ORNAN|Ensembl=ENSOANG00000005350|UniProtKB=F6X852	Uncharacterized protein	ISS	11533252	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	MOUSE|MGI=MGI=109525|UniProtKB=Q9QUQ5	Short transient receptor potential channel 4	IDA	11055438	PubMed	PTHR10117:SF25	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 4
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00006	Apoptosis signaling pathway	P00310	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00170	Aph-1	HUMAN|HGNC=24080|UniProtKB=Q8WW43	Gamma-secretase subunit APH-1B	IDA	12110170	PubMed	PTHR12889:SF1	GAMMA-SECRETASE SUBUNIT APH-1B
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IDA	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	HUMAN|HGNC=130|UniProtKB=P62736	Actin, aortic smooth muscle	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01239	Cul-1	DICDI|dictyBase=DDB_G0291972|UniProtKB=O60999	Cullin-1	IDA	12628165	PubMed	PTHR11932:SF125	CULLIN-1
P00009	Axon guidance mediated by netrin	P00359	NFAT	HUMAN|HGNC=7776|UniProtKB=Q13469	Nuclear factor of activated T-cells, cytoplasmic 2	IDA	12787506	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00005	Angiogenesis	P00217	STAT3	HUMAN|HGNC=11364|UniProtKB=P40763	Signal transducer and activator of transcription 3	IDA	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00036	Interleukin signaling pathway	P00990	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02738	De novo purine biosynthesis	P02901	Adenosuccinate lyase	HALSA|EnsemblGenome=VNG_0415G|UniProtKB=Q9HS42	Adenylosuccinate lyase	ISS			PTHR43411:SF1	ADENYLOSUCCINATE LYASE
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00018	EGF receptor signaling pathway	P00565	PKC	MONDO|Ensembl=ENSMODG00000008318|UniProtKB=F7FGD2	Serine/threonine-protein kinase	ISS	12676944	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P04393	Ras Pathway	P04570	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01185	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00021	FGF signaling pathway	P00629	PP2A	RAT|RGD=6503701|UniProtKB=F1MAA3	Protein LOC100909464	ISS	12110603	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_114958|UniProtKB=C3XZ13	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF359	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01408	Akt/PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00629	PP2A	DROME|FlyBase=FBgn0023177|UniProtKB=O76932	Serine/threonine-protein phosphatase 4 catalytic subunit	ISS			PTHR11668:SF22	SERINE/THREONINE-PROTEIN PHOSPHATASE 4 CATALYTIC SUBUNIT
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01159	SOS	DICDI|dictyBase=DDB_G0284329|UniProtKB=Q54PQ4	Ras guanine nucleotide exchange factor A	ISS			PTHR23113:SF236	RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR A
P00018	EGF receptor signaling pathway	P00552	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00019	Endothelin signaling pathway	P00568	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IGI	15572354	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	HUMAN|HGNC=10939|UniProtKB=P43005	Excitatory amino acid transporter 3	ISS	96032356	PubMed	PTHR11958:SF69	EXCITATORY AMINO ACID TRANSPORTER 3
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02756	N-acetylglucosamine metabolism	P03036	N-acetylglucosamine-6-phosphate deacetylase	STRCO|Gene=CAB93044|UniProtKB=Q9KXV7	N-acetylglucosamine-6-phosphate deacetylase	ISS			PTHR11113:SF1	N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	ISS	10704417	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	YEAST|SGD=S000003412|UniProtKB=P49723	Ribonucleoside-diphosphate reductase small chain 2	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MOUSE|MGI=MGI=1913963|UniProtKB=P61161	Actin-related protein 2	ISS	11889126	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P04397	p53 pathway by glucose deprivation	P04639	AMPK	RAT|RGD=3387|UniProtKB=P54645	5'-AMP-activated protein kinase catalytic subunit alpha-1	ISS			PTHR24343:SF306	5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1
P00029	Huntington disease	P00778	NMDA receptor	MACMU|Ensembl=ENSMMUG00000016675|UniProtKB=F6VTB5	Uncharacterized protein	ISS	11554549	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P05912	Dopamine receptor mediated signaling pathway	P05960	VAT2	PANTR|Ensembl=ENSPTRG00000002979|UniProtKB=H2Q2M8	Uncharacterized protein	ISS	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00029	Huntington disease	P00807	Actin	ARATH|TAIR=AT2G42100|UniProtKB=Q8RYC2	Putative actin-5	IDA	10974003	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P04393	Ras Pathway	P04569	Cdc42	DANRE|ZFIN=ZDB-GENE-030131-8783|UniProtKB=Q52WY2	Ras-like protein Cdc42a	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=7574|UniProtKB=Q9Y623	Myosin-4	IC	10938134	PubMed	PTHR13140:SF681	MYOSIN-4
P05915	Opioid proenkephalin pathway	P05994	G-protein	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8971|UniProtKB=O00443	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00269	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00056	VEGF signaling pathway	P01408	Akt/PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00019	Endothelin signaling pathway	P00568	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IGI	10747026	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00005	Angiogenesis	P00219	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000010521|UniProtKB=F7DQK7	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00029	Huntington disease	P00807	Actin	DICPU|Gene=DICPUDRAFT_48914|UniProtKB=F0ZK40	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF154	ACTIN-17-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00047	PDGF signaling pathway	P01167	Ets	BOVIN|Ensembl=ENSBTAG00000000332|UniProtKB=F1MET2	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF31	ETS DOMAIN-CONTAINING TRANSCRIPTION FACTOR ERF
P00029	Huntington disease	P00807	Actin	DANRE|ZFIN=ZDB-GENE-030131-172|UniProtKB=Q6IQR3	Actin, alpha, cardiac muscle 1a	IDA	14684598	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00006	Apoptosis signaling pathway	P00269	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02738	De novo purine biosynthesis	P02907	dADP kinase	MOUSE|MGI=MGI=97356|UniProtKB=Q01768	Nucleoside diphosphate kinase B	ISS			PTHR11349:SF57	NUCLEOSIDE DIPHOSPHATE KINASE B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	RCA			PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	IDA	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00005	Angiogenesis	P00211	GSK3beta	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	HUMAN|HGNC=6266|UniProtKB=P48544	G protein-activated inward rectifier potassium channel 4	IDA	12374786	PubMed	PTHR11767:SF52	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 4
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	PANTR|Ensembl=ENSPTRG00000002956|UniProtKB=H2Q2L5	Uncharacterized protein	ISS	12730078	PubMed	PTHR24248:SF54	BETA-1 ADRENERGIC RECEPTOR
P00005	Angiogenesis	P00203	Erk	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05918	p38 MAPK pathway	P06026	MEKK4	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	MOUSE|MGI=MGI=88296|UniProtKB=O55017	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	8386525	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00036	Interleukin signaling pathway	P00990	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IC	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	MYCTU|EnsemblGenome=Rv3315c|UniProtKB=P9WPH3	Cytidine deaminase	ISS			PTHR11644:SF2	CYTIDINE DEAMINASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	MOUSE|MGI=MGI=87978|UniProtKB=Q9WTP6	Adenylate kinase 2, mitochondrial	ISS			PTHR23359:SF117	ADENYLATE KINASE 2, MITOCHONDRIAL
P00018	EGF receptor signaling pathway	P00561	STAT	MACMU|Ensembl=ENSMMUG00000010705|UniProtKB=F7G8V4	Signal transducer and activator of transcription	ISS	8584036	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00006	Apoptosis signaling pathway	P00260	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	PANTR|Ensembl=ENSPTRG00000006358|UniProtKB=H2Q8B9	Bone morphogenetic protein 4	ISS	9759503	PubMed	PTHR11848:SF165	BONE MORPHOGENETIC PROTEIN 4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00892	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	15210125	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00019	Endothelin signaling pathway	P00591	PLCbeta	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00047	PDGF signaling pathway	P01152	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	20908895	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	RAT|RGD=67399|UniProtKB=Q64716	Insulin receptor-related protein	ISS	12644000	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00046	Oxidative stress response	P01137	MNK1/2	BOVIN|Gene=MKNK1|UniProtKB=Q58D94	MAP kinase-interacting serine/threonine-protein kinase 1	ISS	97299868	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01161	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00219	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000008826|UniProtKB=F6XUU0	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00046	Oxidative stress response	P01131	MKP5	MOUSE|MGI=MGI=1919599|UniProtKB=Q9D7X3	Dual specificity protein phosphatase 3	TAS			PTHR10159:SF485	DUAL SPECIFICITY PROTEIN PHOSPHATASE 3
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	BOVIN|Ensembl=ENSBTAG00000000219|UniProtKB=F1MCL3	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00029	Huntington disease	P00775	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	20010089	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00006	Apoptosis signaling pathway	P00260	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00206	Wnt	ANOGA|EnsemblGenome=AGAP009731|UniProtKB=Q7PM77	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF98	PROTEIN WNT-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00045	Notch signaling pathway	P01108	Nicastrin	PANTR|Ensembl=ENSPTRG00000001550|UniProtKB=H2Q0E4	Nicastrin	ISS	16096062	PubMed	PTHR21092:SF0	NICASTRIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PRIPA|Gene=PPA23459|UniProtKB=H3FMF2	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00010	B cell activation	P00379	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00550	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8316835	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00048	PI3 kinase pathway	P01177	P110ACT	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01443	Phospholipase C	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MACMU|Ensembl=ENSMMUG00000016256|UniProtKB=F7GM91	Uncharacterized protein	ISS	22028976	PubMed	PTHR13140:SF311	MYOSIN-IIIB
P00021	FGF signaling pathway	P00641	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00019	Endothelin signaling pathway	P00570	PKA	YEAST|SGD=S000001295|UniProtKB=P07278	cAMP-dependent protein kinase regulatory subunit	ISS	91298951	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00029	Huntington disease	P00780	Microtubule	PHYPA|Gene=PHYPADRAFT_110341|UniProtKB=Q6TYR6	Beta-tubulin 2	ISS	9454836	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01413	PI3K	DROME|FlyBase=FBgn0020622|UniProtKB=Q7KTZ2	Pi3K21B, isoform B	ISS	7937853	PubMed	PTHR10155:SF0	PI3K21B, ISOFORM B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	DANRE|ZFIN=ZDB-GENE-021010-3|UniProtKB=Q90WY6	Alpha-2C adrenergic receptor	IDA	11781138	PubMed	PTHR24248:SF25	ALPHA-2C ADRENERGIC RECEPTOR
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	IDA	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BOVIN|Gene=ACTG2|UniProtKB=Q5E9B5	Actin, gamma-enteric smooth muscle	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DANRE|ZFIN=ZDB-GENE-040426-1489|UniProtKB=Q6PHV0	Syntaxin 3A	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00059	p53 pathway	G04693	WIP-1	HUMAN|HGNC=9277|UniProtKB=O15297	Protein phosphatase 1D	ISS			PTHR13832:SF359	PROTEIN PHOSPHATASE 1D
P00006	Apoptosis signaling pathway	P00269	MAPK	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P05916	Opioid prodynorphin pathway	P06002	G-protein	DROME|FlyBase=FBgn0030011|UniProtKB=Q9W3J1	Gbeta5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00059	p53 pathway	P04633	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00624	14-3-3	CANLF|Ensembl=ENSCAFG00000013549|UniProtKB=E2QVP6	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P05913	Enkephalin release	P05972	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	DROME|FlyBase=FBgn0001991|UniProtKB=Q24270	Voltage-dependent calcium channel type D subunit alpha-1	IDA			PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00056	VEGF signaling pathway	P01425	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00036	Interleukin signaling pathway	P00977	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P02775	Salvage pyrimidine ribonucleotides	P03156	CDP kinase	HALSA|EnsemblGenome=VNG_1219G|UniProtKB=Q9HQC9	Uridine kinase	ISS			PTHR10285:SF6	ATP-DEPENDENT KINASE TDA10-RELATED
P00021	FGF signaling pathway	P00645	Rac	DICDI|dictyBase=DDB_G0282365|UniProtKB=P34146	Rho-related protein rac1C	ISS	4757952	gi	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00108	ADAM10	DROME|FlyBase=FBgn0039688|UniProtKB=Q9VAI2	Kuzbanian-like, isoform A	IDA	10097139	PubMed	PTHR11905:SF166	KUZBANIAN-LIKE, ISOFORM A
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00005	Angiogenesis	P00237	FRP	PANTR|Ensembl=ENSPTRG00000012708|UniProtKB=H2QJ36	Frizzled-related protein	ISS	9118218	PubMed	PTHR11309:SF97	SECRETED FRIZZLED-RELATED PROTEIN 3
P00037	Ionotropic glutamate receptor pathway	P01018	Glu1	DROME|FlyBase=FBgn0264000|UniProtKB=M9PHV5	Glutamate receptor IB, isoform B	ISS	10331083	PubMed	PTHR18966:SF270	GLUTAMATE RECEPTOR 1-RELATED
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P02771	Pyrimidine Metabolism	P03129	Aminotransferase	MOUSE|MGI=MGI=2443582|UniProtKB=P61922	4-aminobutyrate aminotransferase, mitochondrial	IDA	8133261	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	BOVIN|Ensembl=ENSBTAG00000018777|UniProtKB=E1BHU9	Uncharacterized protein	ISS	94139935	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	MOUSE|MGI=MGI=98878|UniProtKB=P07607	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00010	B cell activation	P00402	Jnk	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00193	SOS-1	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00012	Cadherin signaling pathway	P00470	F-actin	TRIVA|Gene=TVAG_512800|UniProtKB=A2HNG1	Actin (Fragment)	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00057	Wnt signaling pathway	P01428	Frizzled	BOVIN|Ensembl=ENSBTAG00000020742|UniProtKB=F1MBL4	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF79	FRIZZLED-9
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00274	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00644	p38	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	IGI	4506785	gi	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00182	p38MAPK	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01095	beta	RAT|RGD=2349|UniProtKB=P25109	Acetylcholine receptor subunit beta	ISS	22213672	PubMed	PTHR18945:SF477	ACETYLCHOLINE RECEPTOR SUBUNIT BETA
P04393	Ras Pathway	P04546	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	IDA	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00009	Axon guidance mediated by netrin	P00363	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000022550|UniProtKB=F6Y9I6	Serine/threonine-protein kinase	ISS	12393506	PubMed	PTHR22968:SF9	SERINE/THREONINE-PROTEIN KINASE D1
P05916	Opioid prodynorphin pathway	P05999	provasopressin	DANRE|ZFIN=ZDB-GENE-030407-1|UniProtKB=F1QC27	Uncharacterized protein	ISS			PTHR11681:SF14	SUBFAMILY NOT NAMED
P00046	Oxidative stress response	P01128	MEF-2	HUMAN|HGNC=6996|UniProtKB=Q06413	Myocyte-specific enhancer factor 2C	TAS	11274345	PubMed	PTHR11945:SF25	MYOCYTE-SPECIFIC ENHANCER FACTOR 2C
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00047	PDGF signaling pathway	P01159	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00274	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00046	Oxidative stress response	P01122	TRX	YEAST|SGD=S000004033|UniProtKB=P22217	Thioredoxin-1	ISS			PTHR10438:SF284	THIOREDOXIN-LIKE PROTEIN 1
P00036	Interleukin signaling pathway	P00994	FKHRL1	HUMAN|HGNC=3821|UniProtKB=O43524	Forkhead box protein O3	TAS	10102273	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT3G18040|UniProtKB=Q9LV37	Mitogen-activated protein kinase 9	ISS	10851062	PubMed	PTHR24055:SF246	MITOGEN-ACTIVATED PROTEIN KINASE 15-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01285	TAK	MOUSE|MGI=MGI=1346877|UniProtKB=Q62073	Mitogen-activated protein kinase kinase kinase 7	RCA			PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00896	Insulin IGF	HUMAN|HGNC=5466|UniProtKB=P01344	Insulin-like growth factor II	ISS	4504609	gi	PTHR11454:SF10	INSULIN-LIKE GROWTH FACTOR II
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00046	Oxidative stress response	P01131	MKP5	HUMAN|HGNC=3076|UniProtKB=Q99956	Dual specificity protein phosphatase 9	TAS			PTHR10159:SF388	DUAL SPECIFICITY PROTEIN PHOSPHATASE 9
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CAEEL|WormBase=WBGene00001187|UniProtKB=Q8MQA1	Uncharacterized protein	IC	15621031	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P06959	CCKR signaling map	G06974	uPA	HUMAN|HGNC=9052|UniProtKB=P00749	Urokinase-type plasminogen activator	RCA	17575684	PubMed	PTHR24264:SF38	UROKINASE-TYPE PLASMINOGEN ACTIVATOR
P00029	Huntington disease	P00778	NMDA receptor	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	IDA	14698601	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00005	Angiogenesis	P00238	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00010	B cell activation	P00383	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00010	B cell activation	P00375	Calmodulin	LEIMA|EnsemblGenome=LmjF.09.0910|UniProtKB=Q4QHT2	Putative calmodulin	ISS			PTHR23050:SF245	AT16150P-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00036	Interleukin signaling pathway	P00981	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	TAS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00012	Cadherin signaling pathway	P00462	Casein kinase II	CHICK|Ensembl=ENSGALG00000006197|UniProtKB=P21868	Casein kinase II subunit alpha	ISS	10806215	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	SCHPO|PomBase=SPAC110.03|UniProtKB=Q01112	Cell division control protein 42 homolog	ISS	12932731	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00010	B cell activation	P00398	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IGI	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	NAS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05918	p38 MAPK pathway	P06043	ASK1	HUMAN|HGNC=6857|UniProtKB=Q99683	Mitogen-activated protein kinase kinase kinase 5	TAS	11730323	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00053	T cell activation	P01322	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01319	PAK	CHICK|Ensembl=ENSGALG00000000681|UniProtKB=E1C3P6	Uncharacterized protein	ISS	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	DICDI|dictyBase=DDB_G0272112|UniProtKB=P54697	Myosin-J heavy chain	IC			PTHR13140:SF667	MYOSIN-J HEAVY CHAIN
P00053	T cell activation	P01318	PKC-theta	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00059	p53 pathway	P01486	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CAEBR|Gene=CBG02401|UniProtKB=A8WUE7	Protein CBR-NMR-1	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00034	Integrin signalling pathway	P00906	Rap1	MOUSE|MGI=MGI=2443036|UniProtKB=Q8CFP6	DnaJ homolog subfamily C member 27	ISS			PTHR24073:SF269	DNAJ HOMOLOG SUBFAMILY C MEMBER 27
P00020	FAS signaling pathway	P00600	PARP	HUMAN|HGNC=270|UniProtKB=P09874	Poly [ADP-ribose] polymerase 1	TAS	12101391	PubMed	PTHR10459:SF80	POLY  ADP-RIBOSE  POLYMERASE 1
P00029	Huntington disease	P00810	GAPDH	LEIMA|EnsemblGenome=LmjF.30.2980|UniProtKB=Q4Q6Z4	Glyceraldehyde-3-phosphate dehydrogenase	ISS			PTHR10836:SF52	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00047	PDGF signaling pathway	P01143	ERK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00018	EGF receptor signaling pathway	P00562	p38	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	IGI	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00012	Cadherin signaling pathway	P00470	F-actin	DANRE|ZFIN=ZDB-GENE-040426-2894|UniProtKB=Q7SXW6	Actin-related protein 2-A	ISS	10974003	PubMed	PTHR11937:SF149	ACTIN-RELATED PROTEIN 2-A-RELATED
P00049	Parkinson disease	P01211	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04657	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	PANTR|Ensembl=ENSPTRG00000003983|UniProtKB=H2Q4A0	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00018	EGF receptor signaling pathway	P00565	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	IGI	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00012	Cadherin signaling pathway	P00470	F-actin	ORYSJ|EnsemblGenome=OS10G0510000|UniProtKB=A3C6D7	Actin-2	IC	11889126	PubMed	PTHR11937:SF252	SUBFAMILY NOT NAMED
P00009	Axon guidance mediated by netrin	P00364	cdc42	BOVIN|Ensembl=ENSBTAG00000018691|UniProtKB=A5D7J5	Rho-related GTP-binding protein RhoU	ISS			PTHR24072:SF148	RHO-RELATED GTP-BINDING PROTEIN RHOU
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IDA	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04393	Ras Pathway	P04579	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	8264585	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00021	FGF signaling pathway	P00648	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P02743	Formyltetrahydroformate biosynthesis	P02953	Cobalamin dependent homocysteine transmethylase	PSEAE|EnsemblGenome=PA1843|UniProtKB=Q9I2Q2	Methionine synthase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P06959	CCKR signaling map	G07278	BIRC2	HUMAN|HGNC=590|UniProtKB=Q13490	Baculoviral IAP repeat-containing protein 2	RCA	17704804	PubMed	PTHR10044:SF79	BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 2
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00018	EGF receptor signaling pathway	P00539	14-3-3	DANRE|ZFIN=ZDB-GENE-061023-2|UniProtKB=E7F354	Uncharacterized protein	ISS	22165492	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	RCA	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04396	Vitamin D metabolism and pathway	P04604	FdxR	BOVIN|Gene=FDXR|UniProtKB=P08165	NADPH:adrenodoxin oxidoreductase, mitochondrial	TAS	2845396	PubMed	PTHR11938:SF91	NADPH:ADRENODOXIN OXIDOREDUCTASE, MITOCHONDRIAL
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00005	Angiogenesis	P00203	Erk	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01162	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IC	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IDA	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00059	p53 pathway	P04609	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01444	Wnt	BOVIN|Ensembl=ENSBTAG00000010820|UniProtKB=F1N4C0	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00011	Blood coagulation	P00440	ATIII	XENTR|Xenbase=XB-GENE-975782|UniProtKB=Q66IF8	MGC89905 protein	ISS	18140917	gi	PTHR11461:SF53	ANTITHROMBIN-III
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	TAKRU|Ensembl=ENSTRUG00000015413|UniProtKB=H2UR30	Uncharacterized protein	ISS			PTHR11681:SF13	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05913	Enkephalin release	P05977	G-Protein (s)	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P05916	Opioid prodynorphin pathway	P06000	vasopressin	TAKRU|Ensembl=ENSTRUG00000015631|UniProtKB=H2USP0	Uncharacterized protein	ISS			PTHR11681:SF14	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04558	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IDA	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04393	Ras Pathway	P04559	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00009	Axon guidance mediated by netrin	P00364	cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=7602|UniProtKB=Q9Y4I1	Unconventional myosin-Va	IC			PTHR13140:SF273	UNCONVENTIONAL MYOSIN-VA
P00030	Hypoxia response via HIF activation	P00823	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	ISS	9620264	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00053	T cell activation	P01311	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00034	Integrin signalling pathway	P00949	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00006	Apoptosis signaling pathway	P00302	ATF	MACMU|Ensembl=ENSMMUG00000004499|UniProtKB=F7GFP2	Cyclic AMP-dependent transcription factor ATF-4	ISS	11390664	PubMed	PTHR13044:SF2	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-4
P00046	Oxidative stress response	P01125	Stat1	DANRE|ZFIN=ZDB-GENE-980526-499|UniProtKB=Q6P943	Signal transducer and activator of transcription	TAS	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00839	SHIP	CANLF|Ensembl=ENSCAFG00000005743|UniProtKB=F1PNY0	Uncharacterized protein	ISS	12145149	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IDA	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CAEEL|WormBase=WBGene00004036|UniProtKB=G5EFI8	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P05913	Enkephalin release	P05972	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01444	Wnt	CHICK|Ensembl=ENSGALG00000000839|UniProtKB=P49339	Protein Wnt-11	IDA	8717036	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00786	ARF	TAKRU|Ensembl=ENSTRUG00000011903|UniProtKB=H2TZI4	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF234	ADP-RIBOSYLATION FACTOR 1
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	HUMAN|HGNC=16432|UniProtKB=O14977	Antizyme inhibitor 1	ISS			PTHR11482:SF7	ANTIZYME INHIBITOR 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00054	Toll receptor signaling pathway	P01346	TLR	HUMAN|HGNC=15631|UniProtKB=Q9NYK1	Toll-like receptor 7	ISS			PTHR44312:SF1	TOLL-LIKE RECEPTOR 7
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=4596|UniProtKB=Q14833	Metabotropic glutamate receptor 4	IDA	9407094	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	CANLF|Ensembl=ENSCAFG00000015915|UniProtKB=E2QUF7	Uncharacterized protein	ISS			PTHR18945:SF489	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-9
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	SCHMA|EnsemblGenome=Smp_165490|UniProtKB=C1LZY9	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00054	Toll receptor signaling pathway	P01374	IRF3	HUMAN|HGNC=6118|UniProtKB=Q14653	Interferon regulatory factor 3	ISS			PTHR11949:SF1	INTERFERON REGULATORY FACTOR 3
P00012	Cadherin signaling pathway	P00463	betacatenin	ORNAN|Ensembl=ENSOANG00000006811|UniProtKB=F6WBD5	Uncharacterized protein	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00052	TGF-beta signaling pathway	P01284	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00034	Integrin signalling pathway	P00944	Actin	RAT|RGD=628837|UniProtKB=P60711	Actin, cytoplasmic 1	IPI	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00053	T cell activation	P01312	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IDA	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00021	FGF signaling pathway	P00640	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P00012	Cadherin signaling pathway	P00470	F-actin	STRPU|Gene=CYIIIB|UniProtKB=P18499	Actin, cytoskeletal 3B	IC	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00007	Axon guidance mediated by semaphorins	P00340	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12176041	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00048	PI3 kinase pathway	P01189	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05734	Synaptic vesicle trafficking	P05773	Munc13	MOUSE|MGI=MGI=2149021|UniProtKB=Q8K0T7	Protein unc-13 homolog C	ISS	605836	OMIM	PTHR10480:SF2	PROTEIN UNC-13 HOMOLOG C
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	CHICK|Ensembl=ENSGALG00000012617|UniProtKB=Q06900	Receptor protein serine/threonine kinase	TAS	9395284	PubMed	PTHR23255:SF61	TGF-BETA RECEPTOR TYPE-1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02928	Dihydroorotase	YEAST|SGD=S000004412|UniProtKB=P20051	Dihydroorotase	RCA			PTHR43137:SF1	DIHYDROOROTASE
P00021	FGF signaling pathway	P00629	PP2A	ARATH|TAIR=AT1G69960|UniProtKB=O04951	Serine/threonine-protein phosphatase PP2A-5 catalytic subunit	ISS			PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	8838325	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CAEBR|Gene=CBG02162|UniProtKB=A8WS33	Protein CBG02162	ISS	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	ARATH|TAIR=AT4G03330|UniProtKB=Q9ZQZ8	Syntaxin-123	IC			PTHR19957:SF198	SYNTAXIN-123
P00047	PDGF signaling pathway	P01143	ERK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00018	EGF receptor signaling pathway	P00562	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IGI	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00059	p53 pathway	P04630	PP2A	MONDO|Ensembl=ENSMODG00000019001|UniProtKB=F7CP86	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04395	Vasopressin synthesis	P04593	Glycopeptide	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	IC	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00046	Oxidative stress response	P01129	JNK1/2	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	TAKRU|Ensembl=ENSTRUG00000007253|UniProtKB=H2SZQ1	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_114976|UniProtKB=C3YP58	Putative uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	BOVIN|Ensembl=ENSBTAG00000019076|UniProtKB=E1BA03	Uncharacterized protein	ISS			PTHR24361:SF182	SERINE/THREONINE-PROTEIN KINASE PAK 6
P00034	Integrin signalling pathway	P00911	B-Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00018	EGF receptor signaling pathway	P00552	Ras	DICDI|dictyBase=DDB_G0283537|UniProtKB=P32254	Ras-like protein rasS	IGI	94119591	PubMed	PTHR24070:SF380	RAS-LIKE PROTEIN RASS
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00059	p53 pathway	P04609	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02734	Chorismate biosynthesis	P02870	3-Phosphoshikimate-1-carboxyvinyl transferase	AQUAE|EnsemblGenome=aq_1536|UniProtKB=O67494	3-phosphoshikimate 1-carboxyvinyltransferase	ISS			PTHR21090:SF5	PENTAFUNCTIONAL AROM POLYPEPTIDE
P00029	Huntington disease	P00805	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00944	Actin	CRYNJ|EnsemblGenome=CNA04650|UniProtKB=Q5KP06	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00008	Axon guidance mediated by Slit/Robo	P00344	Netrin	BOVIN|Ensembl=ENSBTAG00000012137|UniProtKB=F1N0C7	Uncharacterized protein	ISS	9427245	PubMed	PTHR10574:SF365	NETRIN-1
P00059	p53 pathway	G04694	p110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00990	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00778	NMDA receptor	RAT|RGD=2739|UniProtKB=Q00961	Glutamate receptor ionotropic, NMDA 2C	IDA	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	8925912	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00019	Endothelin signaling pathway	P00566	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	TAS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00057	Wnt signaling pathway	P01444	Wnt	PANTR|Ensembl=ENSPTRG00000015034|UniProtKB=H2QMT4	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P02781	Threonine biosynthesis	P03190	Threonine synthase	CANLF|Ensembl=ENSCAFG00000004265|UniProtKB=E2RR17	Uncharacterized protein	ISS			PTHR43515:SF1	THREONINE SYNTHASE-LIKE 1
P04393	Ras Pathway	P04570	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00029	Huntington disease	P00778	NMDA receptor	ANOGA|EnsemblGenome=AGAP001478|UniProtKB=Q7PXM3	AGAP001478-PA	IDA	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00050	Plasminogen activating cascade	P01251	MMP-3	MOUSE|MGI=MGI=97010|UniProtKB=P28862	Stromelysin-1	ISS	93013057	PubMed	PTHR10201:SF215	STROMELYSIN-1
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	MACMU|Ensembl=ENSMMUG00000010678|UniProtKB=F7AXI7	Uncharacterized protein	ISS	1706187	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00059	p53 pathway	P04630	PP2A	RAT|RGD=3381|UniProtKB=P62716	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01164	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00029	Huntington disease	P00790	beta-Tubulin	IXOSC|EnsemblGenome=ISCW017136|UniProtKB=B7PA95	Beta tubulin	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P05731	GABA-B receptor II signaling	P05755	Gbeta	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00029	Huntington disease	P00775	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00019	Endothelin signaling pathway	P00566	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	RAT|RGD=1304556|UniProtKB=P63259	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00047	PDGF signaling pathway	P01167	Ets	MOUSE|MGI=MGI=95455|UniProtKB=P27577	Protein C-ets-1	ISS	15298723	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	STRPU|EnsemblGenome=SPU_018419|UniProtKB=W4YRI6	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01159	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P02772	Pyruvate metabolism	P03137	Citrate Lyase	MOUSE|MGI=MGI=103251|UniProtKB=Q91V92	ATP-citrate synthase	ISS			PTHR23118:SF0	ATP-CITRATE SYNTHASE
P04398	p53 pathway feedback loops 2	P04667	p21	HUMAN|HGNC=1784|UniProtKB=P38936	Cyclin-dependent kinase inhibitor 1	ISS			PTHR10265:SF16	CYCLIN-DEPENDENT KINASE INHIBITOR 1
P00048	PI3 kinase pathway	P01202	p85	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01093	AChE	CAEEL|WormBase=WBGene00000037|UniProtKB=Q9U295	Carboxylic ester hydrolase	IC			PTHR43918:SF5	CHOLINESTERASE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	DANRE|ZFIN=ZDB-GENE-030131-9435|UniProtKB=F1R8S3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IPI	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00030	Hypoxia response via HIF activation	P00819	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	ORNAN|Ensembl=ENSOANG00000002406|UniProtKB=F7BAS2	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00018	EGF receptor signaling pathway	P00543	ERK1-2	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00052	TGF-beta signaling pathway	G01548	I-SMAD	MOUSE|MGI=MGI=1336883|UniProtKB=O35182	Mothers against decapentaplegic homolog 6	IGI	9335505	PubMed	PTHR13703:SF28	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 6
P00006	Apoptosis signaling pathway	P00302	ATF	MOUSE|MGI=MGI=88495|UniProtKB=P27699	cAMP-responsive element modulator	ISS			PTHR22952:SF97	CAMP-RESPONSIVE ELEMENT MODULATOR
P00058	mRNA splicing	P01476	U4	RAT|RGD=1310555|UniProtKB=A0A0G2JTI7	Protein Prpf3	ISS	9328476	PubMed	PTHR14212:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3
P00018	EGF receptor signaling pathway	P00551	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00019	Endothelin signaling pathway	P00566	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00046	Oxidative stress response	P01129	JNK1/2	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00034	Integrin signalling pathway	P00913	Csk	CANLF|Ensembl=ENSCAFG00000017945|UniProtKB=E2RFF7	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P06664	Gonadotropin-releasing hormone receptor pathway	P06856	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	RCA	8262390	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00037	Ionotropic glutamate receptor pathway	P01005	NR2D	MOUSE|MGI=MGI=95823|UniProtKB=Q03391	Glutamate receptor ionotropic, NMDA 2D	ISS	11554549	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06850	PKCs(3)	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	RCA	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00004	Alzheimer disease-presenilin pathway	P00144	Ire-1	RAT|RGD=1559716|UniProtKB=A0A0G2K2H4	Protein Ern1	ISS	10619423	PubMed	PTHR13954:SF17	SERINE/THREONINE-PROTEIN KINASE/ENDORIBONUCLEASE IRE1
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	PANTR|Ensembl=ENSPTRG00000020589|UniProtKB=H2QWQ6	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04393	Ras Pathway	P04556	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	MOUSE|MGI=MGI=96828|UniProtKB=Q91ZX7	Prolow-density lipoprotein receptor-related protein 1	IDA	11907044	PubMed	PTHR44025:SF2	PROLOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	HUMAN|HGNC=1963|UniProtKB=Q05901	Neuronal acetylcholine receptor subunit beta-3	IC	15155845	PubMed	PTHR18945:SF75	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-3
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	DANRE|ZFIN=ZDB-GENE-040718-144|UniProtKB=Q6DHE8	Rho-related GTP-binding protein RhoA-D	ISS	12024019	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P02734	Chorismate biosynthesis	P02873	Shikimate dehydrogenase	RHOBA|EnsemblGenome=RB6488|UniProtKB=Q7UQ72	Shikimate dehydrogenase (NADP(+))	ISS			PTHR21089:SF1	BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE/SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	HUMAN|HGNC=20774|UniProtKB=P04350	Tubulin beta-4A chain	ISS	9454836	PubMed	PTHR11588:SF253	TUBULIN BETA-4A CHAIN
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	MACMU|Ensembl=ENSMMUG00000015892|UniProtKB=F7BVK0	Uncharacterized protein	ISS	10617630	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00034	Integrin signalling pathway	P00916	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=2136746|UniProtKB=Q91UZ8	MCG141285	IDA	8120095	PubMed	PTHR24028:SF58	MCG141285
P00056	VEGF signaling pathway	P01408	Akt/PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00029	Huntington disease	P00790	beta-Tubulin	PANTR|Ensembl=ENSPTRG00000017939|UniProtKB=Q7JJU6	Tubulin beta chain	ISS	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00034	Integrin signalling pathway	P00925	MEK	CHICK|Ensembl=ENSGALG00000001001|UniProtKB=F1P3T1	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00048	PI3 kinase pathway	P01192	p110	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	HUMAN|HGNC=7574|UniProtKB=Q9Y623	Myosin-4	ISS	10938134	PubMed	PTHR13140:SF681	MYOSIN-4
P00018	EGF receptor signaling pathway	P00545	JNK1-3	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00049	Parkinson disease	P01238	14-3-3	RAT|RGD=3978|UniProtKB=P68511	14-3-3 protein eta	ISS	6756037	gi	PTHR18860:SF16	14-3-3 PROTEIN ETA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	HUMAN|HGNC=10625|UniProtKB=Q9Y258	C-C motif chemokine 26	IDA	12689651	PubMed	PTHR12015:SF73	C-C MOTIF CHEMOKINE 26
P00017	DNA replication	P00527	Histones	MACMU|Ensembl=ENSMMUG00000030873|UniProtKB=F6Y435	Histone H3	ISS	20448842	PubMed	PTHR11426:SF170	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00057	Wnt signaling pathway	P01444	Wnt	MACMU|Ensembl=ENSMMUG00000006921|UniProtKB=F7EV26	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2518|UniProtKB=P18901	D(1A) dopamine receptor	IDA			PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P06664	Gonadotropin-releasing hormone receptor pathway	P06745	EGF	MOUSE|MGI=MGI=95290|UniProtKB=P01132	Pro-epidermal growth factor	RCA			PTHR44717:SF1	PRO-EPIDERMAL GROWTH FACTOR
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00038	JAK/STAT signaling pathway	P01027	STAT	BOVIN|Gene=STAT5B|UniProtKB=Q9TUM3	Signal transducer and activator of transcription 5B	ISS	20119183	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00049	Parkinson disease	P01230	Src kinase	CHICK|Ensembl=ENSGALG00000003855|UniProtKB=P00523	Proto-oncogene tyrosine-protein kinase Src	IDA	11078745	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	MOUSE|MGI=MGI=102806|UniProtKB=P27038	Activin receptor type-2A	TAS	11252892	PubMed	PTHR23255:SF64	ACTIVIN RECEPTOR TYPE-2A
P04393	Ras Pathway	P04548	ATF2	PANTR|Ensembl=ENSPTRG00000012660|UniProtKB=H2QJ07	Activating transcription factor 2	ISS	10487205	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00029	Huntington disease	P00807	Actin	XENTR|Xenbase=XB-GENE-490883|UniProtKB=Q6NVA9	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P04392	P53 pathway feedback loops 1	P04538	Pirh-2	BOVIN|Ensembl=ENSBTAG00000007189|UniProtKB=A4IFE2	RCHY1 protein	ISS	607680	OMIM	PTHR21319:SF20	RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04393	Ras Pathway	P04542	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MOUSE|MGI=MGI=87905|UniProtKB=P68033	Actin, alpha cardiac muscle 1	IC	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MOUSE|MGI=MGI=1336171|UniProtKB=Q9DAS9	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IDA	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00269	MAPK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00010	B cell activation	P00384	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	RCA	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05726	2-arachidonoylglycerol biosynthesis	P05735	PLA1	HUMAN|HGNC=18483|UniProtKB=Q8WWY8	Lipase member H	IC			PTHR11610:SF12	LIPASE MEMBER H
P00005	Angiogenesis	P00251	cPLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	IDA	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_125401|UniProtKB=C3ZTX6	Putative uncharacterized protein	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000003043|UniProtKB=P63212	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00034	Integrin signalling pathway	P00912	Arp2/3	PANTR|Ensembl=ENSPTRG00000012911|UniProtKB=H2QJE2	Uncharacterized protein	ISS	10940259	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00057	Wnt signaling pathway	P01465	Ggamma	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00015	Circadian clock system	P00506	BMAL1	MOUSE|MGI=MGI=1096381|UniProtKB=Q9WTL8	Aryl hydrocarbon receptor nuclear translocator-like protein 1	ISS	11163178	PubMed	PTHR23042:SF52	ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 1
P00060	Ubiquitin proteasome pathway	P01491	E2	MOUSE|MGI=MGI=1343188|UniProtKB=P60605	Ubiquitin-conjugating enzyme E2 G2	ISS			PTHR24067:SF154	UBIQUITIN-CONJUGATING ENZYME E2 G2
P00010	B cell activation	P00373	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00059	p53 pathway	P04633	P110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00006	Apoptosis signaling pathway	P00269	MAPK	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04393	Ras Pathway	P04570	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01206	14-3-3	ORNAN|Ensembl=ENSOANG00000007305|UniProtKB=F6XW91	Uncharacterized protein	ISS	1499718	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00059	p53 pathway	P04630	PP2A	BRAFL|Gene=BRAFLDRAFT_123893|UniProtKB=C3XQF4	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT2G18170|UniProtKB=Q39027	Mitogen-activated protein kinase 7	ISS	10514528	PubMed	PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P00048	PI3 kinase pathway	P01189	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=2136018|UniProtKB=Q9QYS1	Protein Wnt-16	TAS	8717036	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P00029	Huntington disease	P00778	NMDA receptor	BOVIN|Ensembl=ENSBTAG00000047202|UniProtKB=G3N3K3	Uncharacterized protein	ISS	11554554	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00029	Huntington disease	P00808	Caspase 8	MACMU|Ensembl=ENSMMUG00000031296|UniProtKB=F7C587	Uncharacterized protein	ISS	11788820	PubMed	PTHR10454:SF162	CASPASE-8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=88397|UniProtKB=Q9ERZ4	Muscarinic acetylcholine receptor M2	IDA	8100450	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TAKRU|Ensembl=ENSTRUG00000014318|UniProtKB=H2UI49	Uncharacterized protein	IC	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P05731	GABA-B receptor II signaling	P05753	Ca channel	BOVIN|Ensembl=ENSBTAG00000014828|UniProtKB=F1N1E0	Uncharacterized protein	ISS	14624853	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00048	PI3 kinase pathway	P01194	S6K	XENTR|Xenbase=XB-GENE-482409|UniProtKB=F6UK84	Uncharacterized protein (Fragment)	ISS	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	HUMAN|HGNC=7851|UniProtKB=Q13232	Nucleoside diphosphate kinase 3	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MACMU|Ensembl=ENSMMUG00000001353|UniProtKB=F7D6T8	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00050	Plasminogen activating cascade	P01246	Plasmin	RAT|RGD=619893|UniProtKB=Q01177	Plasminogen	ISS	15928602	gi	PTHR24261:SF5	PLASMINOGEN
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	NEUCR|EnsemblGenome=EFNCRG00000001037|UniProtKB=Q7SE08	Phosphoinositide phospholipase C	ISS			PTHR10336:SF82	SUBFAMILY NOT NAMED
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ARATH|TAIR=AT1G04810|UniProtKB=Q9MAT0	26S proteasome non-ATPase regulatory subunit 1 homolog B	ISS			PTHR10943:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1
P00019	Endothelin signaling pathway	P00586	Gq	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	14765990	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00193	SOS-1	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00036	Interleukin signaling pathway	P00973	PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00047	PDGF signaling pathway	P01143	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01307	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	RAT|RGD=2027|UniProtKB=P63269	Actin, gamma-enteric smooth muscle	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00034	Integrin signalling pathway	P00948	Rho	XENTR|Xenbase=XB-GENE-489222|UniProtKB=Q28GJ8	Ras homolog gene family, member A	ISS	11360179	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00057	Wnt signaling pathway	P01443	Phospholipase C	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00029	Huntington disease	P00775	Rac	BRAFL|Gene=BRAFLDRAFT_122664|UniProtKB=C3ZIB9	Putative uncharacterized protein	ISS			PTHR24072:SF192	CDC42 HOMOLOG
P00056	VEGF signaling pathway	P01417	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CIOIN|Ensembl=ENSCING00000007153|UniProtKB=L7N0T1	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00049	Parkinson disease	P01236	Casein kinase II	ORNAN|Ensembl=ENSOANG00000012115|UniProtKB=F7F9Q9	Uncharacterized protein	ISS	10806215	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00010	B cell activation	P00373	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00010	B cell activation	P00372	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8479536	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	TAS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00005	Angiogenesis	P00219	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01465	Ggamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P02759	Pyridoxal-5-phosphate biosynthesis	P03058	Phosphohydroxythreonine aminotransferase	BACSU|EnsemblGenome=BSU10020|UniProtKB=P80862	Phosphoserine aminotransferase	ISS	9384377	PubMed	PTHR43247:SF2	PHOSPHOSERINE AMINOTRANSFERASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	PANTR|Ensembl=ENSPTRG00000001436|UniProtKB=H2Q085	Synaptotagmin XI	ISS			PTHR10024:SF115	SYNAPTOTAGMIN-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00036	Interleukin signaling pathway	P00990	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01435	SWI/SNF	ARATH|TAIR=AT3G06400|UniProtKB=Q8RWY3	ISWI chromatin-remodeling complex ATPase CHR11	ISS	11532957	PubMed	PTHR10799:SF879	CHROMATIN-REMODELING COMPLEX ATPASE CHAIN ISWI
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00004	Alzheimer disease-presenilin pathway	P00111	C99	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	BOVIN|Ensembl=ENSBTAG00000020887|UniProtKB=F1MP22	Uncharacterized protein	ISS	8386525	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	CANLF|Ensembl=ENSCAFG00000012129|UniProtKB=E2RBX1	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF27	G PROTEIN-COUPLED RECEPTOR KINASE 5
P00059	p53 pathway	P04616	PDK1/2	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	TAS	11256888	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P02759	Pyridoxal-5-phosphate biosynthesis	P03061	Pyridoxine-5-phosphate oxidase	HUMAN|HGNC=30260|UniProtKB=Q9NVS9	Pyridoxine-5'-phosphate oxidase	ISS	9601034	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04397	p53 pathway by glucose deprivation	P04641	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	HUMAN|HGNC=1389|UniProtKB=Q00975	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	15079861	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00047	PDGF signaling pathway	P01143	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	97102671	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00029	Huntington disease	P00780	Microtubule	ORYSJ|EnsemblGenome=OS03G0105600|UniProtKB=Q8H7U1	Tubulin beta-2 chain	IDA	12932731	PubMed	PTHR11588:SF178	TUBULIN BETA-7 CHAIN
P00005	Angiogenesis	P00195	APC	BOVIN|Ensembl=ENSBTAG00000018852|UniProtKB=F1MV51	Uncharacterized protein	ISS	12549854	PubMed	PTHR12607:SF11	ADENOMATOUS POLYPOSIS COLI PROTEIN
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	9009705	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00005	Angiogenesis	P00237	FRP	MOUSE|MGI=MGI=892014|UniProtKB=Q8C4U3	Secreted frizzled-related protein 1	ISS	9096311	PubMed	PTHR11309:SF87	SECRETED FRIZZLED-RELATED PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	88241036	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00029	Huntington disease	P00807	Actin	DANRE|ZFIN=ZDB-GENE-000329-1|UniProtKB=Q7ZVI7	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00030	Hypoxia response via HIF activation	P00824	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	TAS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	HUMAN|HGNC=1987|UniProtKB=Q99967	Cbp/p300-interacting transactivator 2	ISS	9865691	PubMed	PTHR17045:SF7	CBP/P300-INTERACTING TRANSACTIVATOR 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01287	BAMBI	BOVIN|Ensembl=ENSBTAG00000003045|UniProtKB=Q1RMX1	BMP and activin membrane-bound inhibitor homolog	ISS	10519551	PubMed	PTHR15505:SF1	BMP AND ACTIVIN MEMBRANE-BOUND INHIBITOR HOMOLOG
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	10514528	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00736	CalDAG-GEF	PANTR|Ensembl=ENSPTRG00000006905|UniProtKB=H2Q951	Uncharacterized protein	ISS	10835426	PubMed	PTHR23113:SF174	RAS GUANYL-RELEASING PROTEIN 1
P00049	Parkinson disease	P01232	CASK	MACMU|Ensembl=ENSMMUG00000022578|UniProtKB=F7BKQ5	Uncharacterized protein	ISS	11679592	PubMed	PTHR23122:SF40	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	DEIRA|EnsemblGenome=DR_2632|UniProtKB=Q9RR65	Dihydrofolate reductase	ISS			PTHR22778:SF16	DIHYDROFOLATE REDUCTASE
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00029	Huntington disease	P00805	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00474	Wnt	MACMU|Ensembl=ENSMMUG00000020810|UniProtKB=F7H7P6	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF84	PROTEIN WNT-9B
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	IC	14744463	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00840	GPRK	RAT|RGD=61986|UniProtKB=P97711	G protein-coupled receptor kinase 6	ISS	8288567	PubMed	PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P02723	Adenine and hypoxanthine salvage pathway	P02811	Adenosine deaminase	CAEEL|WormBase=WBGene00015551|UniProtKB=H2KYI5	Uncharacterized protein	ISS			PTHR11409:SF43	ADENOSINE DEAMINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	XENTR|Xenbase=XB-GENE-6469705|UniProtKB=Q6P8G3	Actin, alpha sarcomeric/skeletal	ISS	14684598	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00034	Integrin signalling pathway	P00906	Rap1	MONDO|Ensembl=ENSMODG00000024599|UniProtKB=F7DGX0	Uncharacterized protein	ISS	8576107	PubMed	PTHR24070:SF194	RAS-RELATED PROTEIN RAP-2B
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	BOVIN|Ensembl=ENSBTAG00000004216|UniProtKB=F1MSX4	Uncharacterized protein	ISS	21735556	gi	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00034	Integrin signalling pathway	P00923	Arf1	MACMU|Ensembl=ENSMMUG00000021421|UniProtKB=F7EF01	Uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF234	ADP-RIBOSYLATION FACTOR 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00774	Dynein complex	BRAFL|Gene=BRAFLDRAFT_114344|UniProtKB=C3YNF2	Putative uncharacterized protein	ISS	9454836	PubMed	PTHR11886:SF35	DYNEIN LIGHT CHAIN 2, CYTOPLASMIC
P02768	Proline biosynthesis	P03114	Glutamyl kinase	BACSU|EnsemblGenome=BSU18470|UniProtKB=O07509	Glutamate 5-kinase 2	ISS			PTHR43654:SF3	GLUTAMATE 5-KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	HUMAN|HGNC=672|UniProtKB=P84095	Rho-related GTP-binding protein RhoG	ISS			PTHR24072:SF158	RHO-RELATED GTP-BINDING PROTEIN RHOG
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=1309999|UniProtKB=Q922R0	cAMP-dependent protein kinase catalytic subunit PRKX	IC	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	TAS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P02734	Chorismate biosynthesis	P02870	3-Phosphoshikimate-1-carboxyvinyl transferase	STRCO|EnsemblGenome=CAB94597|UniProtKB=Q9K4A7	3-phosphoshikimate 1-carboxyvinyltransferase 1	ISS			PTHR21090:SF5	PENTAFUNCTIONAL AROM POLYPEPTIDE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	MACMU|Ensembl=ENSMMUG00000014498|UniProtKB=F7GEI8	Uncharacterized protein	ISS	11976940	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01435	SWI/SNF	YEAST|SGD=S000001933|UniProtKB=P43609	Chromatin structure-remodeling complex protein RSC8	IDA	11532957	PubMed	PTHR12802:SF65	CHROMATIN STRUCTURE-REMODELING COMPLEX PROTEIN RSC8
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	ARATH|TAIR=AT5G61210|UniProtKB=Q9S7P9	SNAP25 homologous protein SNAP33	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04393	Ras Pathway	P04541	p90RSK	CANLF|Ensembl=ENSCAFG00000013171|UniProtKB=E2RP04	Uncharacterized protein	ISS	6755374	gi	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TAKRU|Ensembl=ENSTRUG00000005494|UniProtKB=P53483	Actin, alpha anomalous	IC	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MACMU|Ensembl=ENSMMUG00000016256|UniProtKB=F7GM91	Uncharacterized protein	ISS	22028976	PubMed	PTHR13140:SF311	MYOSIN-IIIB
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00018	EGF receptor signaling pathway	P00552	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	MACMU|Ensembl=ENSMMUG00000012305|UniProtKB=F7DLC9	Tyrosine-protein kinase receptor	ISS	11182407	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	IDA	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00048	PI3 kinase pathway	P01179	PKB	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01063	CAT	PANTR|Ensembl=ENSPTRG00000002489|UniProtKB=H2RAF8	Uncharacterized protein	ISS	92155737	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00047	PDGF signaling pathway	P01150	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00012	Cadherin signaling pathway	P00470	F-actin	STRPU|EnsemblGenome=SPU_006797|UniProtKB=W4XTP5	Uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00024	Glycolysis	P00679	Aldolase	CANLF|Ensembl=ENSCAFG00000018144|UniProtKB=F1PNI3	Uncharacterized protein	ISS	3391172	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00018	EGF receptor signaling pathway	P00562	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IGI	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	ANOGA|EnsemblGenome=AGAP005911|UniProtKB=Q7Q6D4	AGAP005911-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P06213	DPP signaling pathway	P06277	PUT	DROME|Gene=Dmel_CG7904|UniProtKB=A0A0B4KG59	Serine/threonine-protein kinase receptor	IEA	9395284	PubMed	PTHR23255:SF70	SERINE/THREONINE-PROTEIN KINASE RECEPTOR
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02788	Xanthine and guanine salvage pathway	P03248	Deoxyguanosine phosphorylase	DROME|FlyBase=FBgn0035348|UniProtKB=M9PE19	Uncharacterized protein, isoform H	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	XENTR|Xenbase=XB-GENE-957432|UniProtKB=F6QMZ6	CTP synthase	ISS			PTHR11550:SF8	CTP SYNTHASE 1
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00898	FKHR	PANTR|Ensembl=ENSPTRG00000005806|UniProtKB=H2Q7G4	Uncharacterized protein	TAS			PTHR11829:SF159	FORKHEAD BOX PROTEIN O1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	IDA	10514528	PubMed	PTHR24055:SF330	SUBFAMILY NOT NAMED
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	ORNAN|Ensembl=ENSOANG00000000999|UniProtKB=F6WN02	Actin-related protein 2/3 complex subunit 5	ISS	12473693	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	P01443	Phospholipase C	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ARATH|TAIR=AT2G42090|UniProtKB=P93738	Putative actin-9	ISS	10974003	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00029	Huntington disease	P00775	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	10891487	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	RAT|RGD=620023|UniProtKB=P10980	Muscarinic acetylcholine receptor M2	ISS	12181435	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00047	PDGF signaling pathway	P01162	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00640	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00015	Circadian clock system	P00506	BMAL1	DANRE|ZFIN=ZDB-GENE-000509-1|UniProtKB=Q9I879	Bmal1	ISS			PTHR23042:SF52	ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	HUMAN|HGNC=7775|UniProtKB=O95644	Nuclear factor of activated T-cells, cytoplasmic 1	ISS	9133421	PubMed	PTHR12533:SF5	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 1
P00012	Cadherin signaling pathway	P00474	Wnt	XENTR|Ensembl=ENSXETG00000024231|UniProtKB=F6TCQ4	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P00048	PI3 kinase pathway	P01185	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00018	EGF receptor signaling pathway	P00543	ERK1-2	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IGI	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00034	Integrin signalling pathway	P00947	Laminin	MOUSE|MGI=MGI=109321|UniProtKB=P97927	Laminin subunit alpha-4	IPI	2538453	PubMed	PTHR44537:SF1	LAMININ SUBUNIT ALPHA-4
P00051	TCA cycle	P01274	Succinyl CoA Synthetase	HUMAN|HGNC=11449|UniProtKB=P53597	Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial	ISS	97407896	PubMed	PTHR11117:SF2	SUCCINYL-COA LIGASE  ADP/GDP-FORMING  SUBUNIT ALPHA, MITOCHONDRIAL
P00034	Integrin signalling pathway	P00923	Arf1	MOUSE|MGI=MGI=99436|UniProtKB=P61211	ADP-ribosylation factor-like protein 1	ISS	11752622	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	10553940	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00010	B cell activation	P00398	IP3R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00023	General transcription regulation	P00662	TFIIA complex	HUMAN|HGNC=4646|UniProtKB=P52655	Transcription initiation factor IIA subunit 1	ISS	600519	OMIM	PTHR12694:SF7	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CAEBR|Gene=CBG02167|UniProtKB=A8WS37	Protein CBG02167	ISS	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00021	FGF signaling pathway	P00648	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00009	Axon guidance mediated by netrin	P00364	cdc42	CHICK|Ensembl=ENSGALG00000004796|UniProtKB=Q90694	Cell division control protein 42 homolog	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MACMU|Ensembl=ENSMMUG00000019342|UniProtKB=F6PVY4	Uncharacterized protein	ISS	12932731	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008422|UniProtKB=F6VUT7	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IGI	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00010	B cell activation	P00384	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00010	B cell activation	P00371	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000006495|UniProtKB=P11017	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00057	Wnt signaling pathway	P01443	Phospholipase C	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00059	p53 pathway	P01486	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=1305811|UniProtKB=F2Z3R8	Protein Pcdhb15	ISS	8120095	PubMed	PTHR24028:SF69	PROTOCADHERIN BETA-7
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00587	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=1560161|UniProtKB=D3ZTI3	Protein Cdh24	ISS	8120095	PubMed	PTHR24027:SF272	CADHERIN-24
P00004	Alzheimer disease-presenilin pathway	P00127	APP	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05917	Opioid proopiomelanocortin pathway	P06011	AC	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00034	Integrin signalling pathway	P00947	Laminin	MOUSE|MGI=MGI=99914|UniProtKB=P02468	Laminin subunit gamma-1	IPI	2538453	PubMed	PTHR10574:SF270	LAMININ SUBUNIT GAMMA-1
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	CANLF|Ensembl=ENSCAFG00000013422|UniProtKB=F1PAB7	Uncharacterized protein	ISS			PTHR11699:SF228	4-TRIMETHYLAMINOBUTYRALDEHYDE DEHYDROGENASE
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	CHICK|Ensembl=ENSGALG00000013785|UniProtKB=E1BS74	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	RAT|RGD=69281|UniProtKB=P43143	Neuronal acetylcholine receptor subunit alpha-6	IC	85270494	PubMed	PTHR18945:SF82	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-6
P00059	p53 pathway	G04694	p110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00922	Collagen	RAT|RGD=1310255|UniProtKB=D3ZX71	Protein Col9a3	ISS	10778855	PubMed	PTHR44865:SF1	COLLAGEN ALPHA-3 IX  CHAIN
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IGI	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00053	T cell activation	P01297	MEKK	RAT|RGD=620966|UniProtKB=Q62925	Mitogen-activated protein kinase kinase kinase 1	RCA	11730323	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	ISS	11535291	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MOUSE|MGI=MGI=88398|UniProtKB=Q9ERZ3	Muscarinic acetylcholine receptor M3	IDA	12181435	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g210933|UniProtKB=A7SEA7	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P06959	CCKR signaling map	P07103	PRKD1	HUMAN|HGNC=9407|UniProtKB=Q15139	Serine/threonine-protein kinase D1	RCA	11231022	PubMed	PTHR22968:SF9	SERINE/THREONINE-PROTEIN KINASE D1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00029	Huntington disease	P00776	c-Jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00012	Cadherin signaling pathway	P00466	EGFR	PANTR|Ensembl=ENSPTRG00000019196|UniProtKB=H2QUL1	Receptor protein-tyrosine kinase	ISS	20540545	gi	PTHR24416:SF91	EPIDERMAL GROWTH FACTOR RECEPTOR
P00018	EGF receptor signaling pathway	P00546	GAP	RAT|RGD=3168|UniProtKB=P97526	Neurofibromin	ISS	8982875	PubMed	PTHR10194:SF60	NEUROFIBROMIN
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	PANTR|Ensembl=ENSPTRG00000004964|UniProtKB=H2Q5Y6	Receptor protein serine/threonine kinase	ISS			PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P00060	Ubiquitin proteasome pathway	P01491	E2	RAT|RGD=1311626|UniProtKB=D3ZXS8	Huntingtin interacting protein 2 (Predicted), isoform CRA_a	ISS			PTHR44020:SF2	UBIQUITIN-CONJUGATING ENZYME E2 K
P00006	Apoptosis signaling pathway	P00296	DAXX	HUMAN|HGNC=2681|UniProtKB=Q9UER7	Death domain-associated protein 6	IDA	9215629	PubMed	PTHR12766:SF7	DEATH DOMAIN-ASSOCIATED PROTEIN 6
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	BOVIN|Gene=ALDH9A1|UniProtKB=Q2KJH9	4-trimethylaminobutyraldehyde dehydrogenase	ISS			PTHR11699:SF228	4-TRIMETHYLAMINOBUTYRALDEHYDE DEHYDROGENASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00005	Angiogenesis	P00244	MAPKAPK2/3	HUMAN|HGNC=6887|UniProtKB=P49137	MAP kinase-activated protein kinase 2	ISS	7923354	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	TAS	98189216	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	PANTR|Ensembl=ENSPTRG00000002979|UniProtKB=H2Q2M8	Uncharacterized protein	ISS	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P05915	Opioid proenkephalin pathway	P05994	G-protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00014	Cholesterol biosynthesis	P00499	Farnesyl-diphosphate farnesyltransferase	SCHPO|PomBase=SPBC646.05c|UniProtKB=P36596	Squalene synthase	ISS			PTHR11626:SF2	SQUALENE SYNTHASE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00018	EGF receptor signaling pathway	P00551	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IGI	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MOUSE|MGI=MGI=1930076|UniProtKB=Q9Z2B9	Ribosomal protein S6 kinase alpha-4	ISS	6755374	gi	PTHR24351:SF41	RIBOSOMAL PROTEIN S6 KINASE ALPHA-4
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00021	FGF signaling pathway	P00648	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	10395542	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00050	Plasminogen activating cascade	P01263	pro-MMP-1	PANTR|Ensembl=ENSPTRG00000023318|UniProtKB=H2Q4N3	Matrix metallopeptidase 1 (Interstitial collagenase)	ISS	3009463	PubMed	PTHR10201:SF151	INTERSTITIAL COLLAGENASE
P00018	EGF receptor signaling pathway	P00549	EGF	PANTR|Ensembl=ENSPTRG00000007312|UniProtKB=H2R3B1	Uncharacterized protein	RCA			PTHR11100:SF20	PRO-NEUREGULIN-2, MEMBRANE-BOUND ISOFORM-RELATED
P00057	Wnt signaling pathway	P01438	PP2A	HUMAN|HGNC=9300|UniProtKB=P62714	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	IDA	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00189	Fzd	MONDO|Ensembl=ENSMODG00000010505|UniProtKB=F7E9U1	Uncharacterized protein (Fragment)	ISS	8717036	PubMed	PTHR11309:SF81	FRIZZLED-1
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	MACMU|Ensembl=ENSMMUG00000006646|UniProtKB=F7H415	Uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF151	CASEIN KINASE I ISOFORM GAMMA-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	XENTR|Xenbase=XB-GENE-961282|UniProtKB=Q6DF43	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P05913	Enkephalin release	P05972	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	SULSO|EnsemblGenome=SSO0641|UniProtKB=Q59969	Carbamoyl-phosphate synthase large chain	ISS			PTHR11405:SF5	CAD PROTEIN
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IC	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P02772	Pyruvate metabolism	P03132	Pyruvate Kinase	MACMU|Ensembl=ENSMMUG00000004145|UniProtKB=F6XKL2	Pyruvate kinase	ISS	8193145	PubMed	PTHR11817:SF15	PYRUVATE KINASE PKM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BOVIN|Gene=ACTG2|UniProtKB=Q5E9B5	Actin, gamma-enteric smooth muscle	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CHLRE|EnsemblGenome=CHLREDRAFT_185104|UniProtKB=A8J8K0	Myosin heavy chain, class XI	IC			PTHR13140:SF706	UNCONVENTIONAL MYOSIN-VI
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MONDO|Ensembl=ENSMODG00000001389|UniProtKB=F7BD45	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF657	MYOSIN-4
P04393	Ras Pathway	P04570	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04623	CBP	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P06959	CCKR signaling map	P07160	MAP2K5	HUMAN|HGNC=6845|UniProtKB=Q13163	Dual specificity mitogen-activated protein kinase kinase 5	RCA	12239223	PubMed	PTHR24361:SF395	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5
P00047	PDGF signaling pathway	P01159	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00046	Oxidative stress response	P01131	MKP5	MOUSE|MGI=MGI=2387100|UniProtKB=Q91Z46	Dual specificity protein phosphatase 7	ISS			PTHR10159:SF305	DUAL SPECIFICITY PROTEIN PHOSPHATASE 7
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IC	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00005	Angiogenesis	P00226	Delta/Serrate	MOUSE|MGI=MGI=1095416|UniProtKB=Q9QXX0	Protein jagged-1	ISS	10551863	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00047	PDGF signaling pathway	P01152	RasGAP	DROME|FlyBase=FBgn0003969|UniProtKB=Q8IR23	GH13542p	ISS	17737349	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	ANOGA|EnsemblGenome=AGAP000763|UniProtKB=Q7QE97	Serine/threonine-protein kinase receptor	TAS	9395284	PubMed	PTHR23255:SF70	SERINE/THREONINE-PROTEIN KINASE RECEPTOR
P00059	p53 pathway	P04633	P110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	MONDO|Ensembl=ENSMODG00000002570|UniProtKB=F7GF94	Uncharacterized protein	ISS	606023	OMIM	PTHR10917:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00550	Grb2	DROME|FlyBase=FBgn0004638|UniProtKB=Q08012	Protein enhancer of sevenless 2B	ISS	4504111	gi	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00018	EGF receptor signaling pathway	P00543	ERK1-2	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00244	MAPKAPK2/3	CAEEL|WormBase=WBGene00007007|UniProtKB=Q965G5	MAP kinase Activated protein Kinase	ISS			PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00034	Integrin signalling pathway	P00940	Src	DROME|FlyBase=FBgn0264959|UniProtKB=Q9V9J3	Tyrosine-protein kinase Src42A	IPI	11078745	PubMed	PTHR24418:SF292	TYROSINE-PROTEIN KINASE SRC42A
P04393	Ras Pathway	P04572	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00219	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00011	Blood coagulation	P00451	Kininogen	MACMU|Ensembl=ENSMMUG00000003700|UniProtKB=F6SG43	Uncharacterized protein	ISS	125507	gi	PTHR13814:SF12	KININOGEN-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	BOVIN|Ensembl=ENSBTAG00000014828|UniProtKB=F1N1E0	Uncharacterized protein	ISS	11976940	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	IDA	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	HUMAN|HGNC=9999|UniProtKB=P49796	Regulator of G-protein signaling 3	IDA	8756726	PubMed	PTHR10845:SF4	REGULATOR OF G-PROTEIN SIGNALING 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01076	CAT	CAEEL|WormBase=WBGene00007175|UniProtKB=Q17499	Uncharacterized protein	ISS			PTHR22589:SF103	CARNITINE O-ACETYL-TRANSFERASE, ISOFORM A
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01284	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02746	Heme biosynthesis	P02983	Hydroxymethylbilane synthase	PYRAE|EnsemblGenome=PAE0580|UniProtKB=Q8ZYW7	Probable porphobilinogen deaminase	ISS			PTHR11557:SF0	PORPHOBILINOGEN DEAMINASE
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00059	p53 pathway	P01486	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=1950|UniProtKB=P11229	Muscarinic acetylcholine receptor M1	IDA			PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P05912	Dopamine receptor mediated signaling pathway	P05959	FLNA	MACMU|Ensembl=ENSMMUG00000013668|UniProtKB=F7GCM2	Uncharacterized protein	ISS	11911837	PubMed	PTHR43998:SF6	FILAMIN-A
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00057	Wnt signaling pathway	P01451	Galpha	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00034	Integrin signalling pathway	P00923	Arf1	RAT|RGD=621326|UniProtKB=P61212	ADP-ribosylation factor-like protein 1	IPI	11752622	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P00047	PDGF signaling pathway	P01155	Jak	HUMAN|HGNC=6193|UniProtKB=P52333	Tyrosine-protein kinase JAK3	ISS	15179321	PubMed	PTHR24418:SF233	TYROSINE-PROTEIN KINASE JAK3
P00019	Endothelin signaling pathway	P00580	ET-RA/B	CANLF|Gene=EDNRA|UniProtKB=Q5KSU9	Endothelin-1 receptor	ISS	12875994	PubMed	PTHR24243:SF31	ENDOTHELIN-1 RECEPTOR
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IDA	10395542	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00053	T cell activation	P01336	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00139	E-cadherin transmembrane fragment	HUMAN|HGNC=1762|UniProtKB=P22223	Cadherin-3	IDA	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P00058	mRNA splicing	P01478	U2	PANTR|Ensembl=ENSPTRG00000013271|UniProtKB=H2QJZ7	Uncharacterized protein	ISS			PTHR10501:SF21	U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B''
P00019	Endothelin signaling pathway	P00586	Gq	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	HUMAN|HGNC=10934|UniProtKB=P54219	Chromaffin granule amine transporter	ISS	12135927	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00548	RKIP	DROME|FlyBase=FBgn0037431|UniProtKB=Q9I7L3	Uncharacterized protein	ISS			PTHR11362:SF28	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00005	Angiogenesis	P00243	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	BOVIN|Ensembl=ENSBTAG00000002015|UniProtKB=G5E5T2	Uncharacterized protein	ISS	6755374	gi	PTHR24351:SF98	RIBOSOMAL PROTEIN S6 KINASE ALPHA-6
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00642	MEK1-2	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00036	Interleukin signaling pathway	P00973	PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00567	PKG	MACMU|Ensembl=ENSMMUG00000019859|UniProtKB=F7GTI6	cGMP-dependent protein kinase	ISS	12764134	PubMed	PTHR24353:SF24	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00799	JNK-2	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00053	T cell activation	P01315	Calcineurin	MACMU|Ensembl=ENSMMUG00000015714|UniProtKB=F6SFE0	Serine/threonine-protein phosphatase	ISS	12015605	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CANLF|Ensembl=ENSCAFG00000005662|UniProtKB=E2R907	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	DANRE|ZFIN=ZDB-GENE-980526-527|UniProtKB=B3DJ37	Receptor protein serine/threonine kinase	TAS	10683140	PubMed	PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P00057	Wnt signaling pathway	P01435	SWI/SNF	ARATH|TAIR=AT5G19310|UniProtKB=F4K128	Probable ATP-dependent DNA helicase CHR23	IDA	11532957	PubMed	PTHR10799:SF873	ATP-DEPENDENT DNA HELICASE CHR12-RELATED
P00029	Huntington disease	P00807	Actin	ORNAN|Ensembl=ENSOANG00000007716|UniProtKB=F6UDX9	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	PANTR|Ensembl=ENSPTRG00000012911|UniProtKB=H2QJE2	Uncharacterized protein	ISS	17943202	gi	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00025	Hedgehog signaling pathway	P00682	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	PANTR|Gene=CHRM5|UniProtKB=Q5IS53	Muscarinic acetylcholine receptor M5	ISS	10069496	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00037	Ionotropic glutamate receptor pathway	P01026	KA	HUMAN|HGNC=4583|UniProtKB=Q16478	Glutamate receptor ionotropic, kainate 5	ISS	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00053	T cell activation	P01294	NFAT	MACMU|Ensembl=ENSMMUG00000012657|UniProtKB=F7E7J1	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	1170702	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=1748|UniProtKB=P12830	Cadherin-1	IDA	12834808	PubMed	PTHR24027:SF319	CADHERIN-1
P04398	p53 pathway feedback loops 2	P04657	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00054	Toll receptor signaling pathway	P01375	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00046	Oxidative stress response	P01121	MKK3/6	XENTR|Xenbase=XB-GENE-944183|UniProtKB=F7EJU0	Uncharacterized protein (Fragment)	RCA			PTHR24361:SF645	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00048	PI3 kinase pathway	P01182	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	TAS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00056	VEGF signaling pathway	P01411	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00041	Metabotropic glutamate receptor group I pathway	P01062	mGluR1	HUMAN|HGNC=4593|UniProtKB=Q13255	Metabotropic glutamate receptor 1	ISS	9407094	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_127490|UniProtKB=C3XYC5	Putative uncharacterized protein	IDA	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00297	NFkappaB	RAT|RGD=70498|UniProtKB=Q63369	Nuclear factor NF-kappa-B p105 subunit (Fragment)	ISS	8598461	PubMed	PTHR24169:SF9	NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	RAT|RGD=620003|UniProtKB=O08773	Regulator of G-protein signaling 14	IDA	10779778	PubMed	PTHR10845:SF179	REGULATOR OF G-PROTEIN SIGNALING 14
P02781	Threonine biosynthesis	P03191	Homoserine kinase	NEUCR|EnsemblGenome=EFNCRG00000003950|UniProtKB=Q1K791	Homoserine kinase	ISS			PTHR20861:SF1	HOMOSERINE KINASE
P00038	JAK/STAT signaling pathway	P01027	STAT	MACMU|Ensembl=ENSMMUG00000005617|UniProtKB=F6WDY6	Signal transducer and activator of transcription	ISS	94255416	PubMed	PTHR11801:SF19	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 4
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P04397	p53 pathway by glucose deprivation	P04640	p53	MOUSE|MGI=MGI=98834|UniProtKB=P02340	Cellular tumor antigen p53	TAS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MOUSE|MGI=MGI=87909|UniProtKB=P62737	Actin, aortic smooth muscle	IDA	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00019	Endothelin signaling pathway	P00587	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	BOVIN|Ensembl=ENSBTAG00000018204|UniProtKB=Q9BE40	Myosin-1	ISS	10938134	PubMed	PTHR13140:SF484	MYOSIN-1
P00046	Oxidative stress response	P01135	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05731	GABA-B receptor II signaling	P05755	Gbeta	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P02727	Androgen/estrogene/progesterone biosynthesis	P02829	Cholesterol acyltransferase	CANLF|Ensembl=ENSCAFG00000013894|UniProtKB=F1PUL0	O-acyltransferase	ISS	7592824	PubMed	PTHR10408:SF6	STEROL O-ACYLTRANSFERASE 1
P04393	Ras Pathway	P04567	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IDA	96009592	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00019	Endothelin signaling pathway	P00572	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00049	Parkinson disease	P01238	14-3-3	CAEEL|WormBase=WBGene00001502|UniProtKB=Q20655	14-3-3-like protein 2	IDA	97315111	PubMed	PTHR18860:SF13	14-3-3 PROTEIN ZETA
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00029	Huntington disease	P00788	Calpain	PANTR|Ensembl=ENSPTRG00000014661|UniProtKB=H2QM47	Calpain 7	ISS	11675509	PubMed	PTHR10183:SF22	CALPAIN-7
P00060	Ubiquitin proteasome pathway	P01492	E1	MACMU|Ensembl=ENSMMUG00000017428|UniProtKB=F7HPQ2	Uncharacterized protein	ISS			PTHR10953:SF155	UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 1
P00021	FGF signaling pathway	P00644	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	ISS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00041	Metabotropic glutamate receptor group I pathway	P01062	mGluR1	MACMU|Ensembl=ENSMMUG00000016428|UniProtKB=F7GU00	Metabotropic glutamate receptor 1 isoform alpha	ISS	9407094	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00036	Interleukin signaling pathway	P00985	PDK1/2	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	ISS	15210700	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00021	FGF signaling pathway	P00629	PP2A	ARATH|TAIR=AT4G26720|UniProtKB=P48529	Serine/threonine-protein phosphatase PP-X isozyme 1	ISS			PTHR11668:SF380	SERINE/THREONINE-PROTEIN PHOSPHATASE PP-X ISOZYME 1
P00047	PDGF signaling pathway	P01160	IP3 receptor	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	BOVIN|Ensembl=ENSBTAG00000047202|UniProtKB=G3N3K3	Uncharacterized protein	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01418	Paxillin	RAT|RGD=620173|UniProtKB=Q99PD6	Transforming growth factor beta-1-induced transcript 1 protein	ISS			PTHR24216:SF27	TRANSFORMING GROWTH FACTOR BETA-1-INDUCED TRANSCRIPT 1 PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P06664	Gonadotropin-releasing hormone receptor pathway	G06878	Fosb	MOUSE|MGI=MGI=95575|UniProtKB=P13346	Protein fosB	RCA			PTHR23351:SF3	PROTEIN FOSB
P05731	GABA-B receptor II signaling	P05754	Ggamma	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00005	Angiogenesis	P00200	Dsh	MACMU|Ensembl=ENSMMUG00000006553|UniProtKB=F7HRY3	Uncharacterized protein	ISS	11212302	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P00006	Apoptosis signaling pathway	P00280	PACT	HUMAN|HGNC=9438|UniProtKB=O75569	Interferon-inducible double-stranded RNA-dependent protein kinase activator A	ISS			PTHR10910:SF8	INTERFERON-INDUCIBLE DOUBLE-STRANDED RNA-DEPENDENT PROTEIN KINASE ACTIVATOR A
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IDA	176892	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04395	Vasopressin synthesis	P04594	Neurophysin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00006	Apoptosis signaling pathway	P00264	c-IAP1,2	RAT|RGD=621282|UniProtKB=F7FLN8	Protein Birc3	ISS			PTHR10044:SF99	BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 3
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P00998	stargazin	HUMAN|HGNC=1406|UniProtKB=Q9Y698	Voltage-dependent calcium channel gamma-2 subunit	RCA			PTHR12107:SF1	VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-2 SUBUNIT
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00006	Apoptosis signaling pathway	P00316	Bcl-w	MONDO|Ensembl=ENSMODG00000004539|UniProtKB=F6U940	Uncharacterized protein	ISS	10366024	PubMed	PTHR11256:SF13	BCL-2-LIKE PROTEIN 2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00034	Integrin signalling pathway	P00925	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P06209	ALP23B signaling pathway	P06223	ALP23B	DROME|FlyBase=FBgn0031461|UniProtKB=Q9VQG9	Dawdle, isoform A	IEA	12537572	PubMed	PTHR11848:SF226	DAWDLE, ISOFORM A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_114535|UniProtKB=C3ZHN2	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00587	Raf-1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000001384|UniProtKB=F7GL73	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00034	Integrin signalling pathway	P00931	Integrin beta	RAT|RGD=2927|UniProtKB=P49134	Integrin beta-1	IDA	3487386	PubMed	PTHR10082:SF28	INTEGRIN BETA-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	STRPU|EnsemblGenome=SPU_017814|UniProtKB=W4YPT6	Uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF263	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00020	FAS signaling pathway	P00611	Gelsolin	MACMU|Ensembl=ENSMMUG00000013020|UniProtKB=F7HP21	Uncharacterized protein	ISS	9323209	PubMed	PTHR11977:SF29	GELSOLIN
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	IDA	12787066	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01408	Akt/PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	XENTR|Xenbase=XB-GENE-6067221|UniProtKB=F6Z0J4	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00046	Oxidative stress response	P01135	p38	DROME|FlyBase=FBgn0015765|UniProtKB=O62618	Mitogen-activated protein kinase 14A	TAS	11707292	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P04386	Histamine H2 receptor mediated signaling pathway	P04489	H2	RAT|RGD=2831|UniProtKB=P25102	Histamine H2 receptor	ISS	11841575	PubMed	PTHR43893:SF5	HISTAMINE H2 RECEPTOR
P00049	Parkinson disease	P01212	p38 MAPK	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	NAS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IDA	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00048	PI3 kinase pathway	P01181	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IPI	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	ORNAN|Ensembl=ENSOANG00000014180|UniProtKB=F6PFR5	Fructose-bisphosphate aldolase (Fragment)	ISS	7768978	PubMed	PTHR11627:SF3	FRUCTOSE-BISPHOSPHATE ALDOLASE C
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P02788	Xanthine and guanine salvage pathway	P03245	Guanine phosphoribosyl transferase	PANTR|Gene=HPRT1|UniProtKB=A5A6I1	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF6	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	HUMAN|HGNC=6148|UniProtKB=P20701	Integrin alpha-L	IDA	3487386	PubMed	PTHR23220:SF84	INTEGRIN ALPHA-L
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	TAS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00023	General transcription regulation	P00662	TFIIA complex	CAEEL|WormBase=WBGene00013736|UniProtKB=Q9NEX2	Transcription initiation factor IIA subunit 2	ISS			PTHR10966:SF0	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2
P00047	PDGF signaling pathway	P01174	Rho	MACMU|Ensembl=ENSMMUG00000007831|UniProtKB=F7CI83	Rho GTPase-activating protein 1	ISS	14724572	PubMed	PTHR23176:SF28	RHO GTPASE-ACTIVATING PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00859	NFkappaB	RAT|RGD=727889|UniProtKB=Q7TQN4	Protein Rela	RCA			PTHR24169:SF1	TRANSCRIPTION FACTOR P65
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	DROME|FlyBase=FBgn0004168|UniProtKB=P28285	5-hydroxytryptamine receptor 2A	ISS	12181435	PubMed	PTHR24247:SF117	5-HYDROXYTRYPTAMINE RECEPTOR 2A-RELATED
P00021	FGF signaling pathway	P00641	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	TAS	10644715	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P04374	5HT2 type receptor mediated signaling pathway	P04413	K+ channel	HUMAN|HGNC=6278|UniProtKB=O14649	Potassium channel subfamily K member 3	ISS	11875121	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P02738	De novo purine biosynthesis	P02909	GDP reductase	MOUSE|MGI=MGI=98180|UniProtKB=P07742	Ribonucleoside-diphosphate reductase large subunit	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00005	Angiogenesis	P00253	Axin	XENTR|Xenbase=XB-GENE-486781|UniProtKB=F6XWP7	Uncharacterized protein	ISS	9554852	PubMed	PTHR10845:SF11	AXIN-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	BOVIN|Ensembl=ENSBTAG00000046248|UniProtKB=Q58CQ2	Actin-related protein 2/3 complex subunit 1B	ISS	12473693	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P02770	Pyridoxal phosphate salvage pathway	P03120	Pyridoxamine-5-phosphate oxidase	YEAST|SGD=S000000239|UniProtKB=P38075	Pyridoxamine 5'-phosphate oxidase	ISS	8849441	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00054	Toll receptor signaling pathway	P01358	ERK1	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00029	Huntington disease	P00811	Arp2/3 complex	BOVIN|Ensembl=ENSBTAG00000004242|UniProtKB=Q1JP79	Actin-related protein 2/3 complex subunit 1A	ISS	12932731	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00047	PDGF signaling pathway	P01160	IP3 receptor	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=68438|UniProtKB=P35370	Nociceptin receptor	IDA	11259487	PubMed	PTHR24229:SF11	NOCICEPTIN RECEPTOR
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00057	Wnt signaling pathway	P01457	GBeta	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00890	ELK	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	ISS	3183861	gi	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P04371	5-Hydroxytryptamine biosynthesis	P04400	Aromatic L-amino acid decarboxylase	PANTR|Ensembl=ENSPTRG00000019189|UniProtKB=H2QUK8	Uncharacterized protein	ISS	107930	OMIM	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	RAT|RGD=71083|UniProtKB=P30940	5-hydroxytryptamine receptor 1F	IDA			PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	RAT|RGD=1304749|UniProtKB=A0A0G2K0H3	Protein Lrp6	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00029	Huntington disease	P00780	Microtubule	MOUSE|MGI=MGI=107848|UniProtKB=Q9D6F9	Tubulin beta-4A chain	IDA	12932731	PubMed	PTHR11588:SF253	TUBULIN BETA-4A CHAIN
P00018	EGF receptor signaling pathway	P00549	EGF	MOUSE|MGI=MGI=1098246|UniProtKB=P56974	Pro-neuregulin-2, membrane-bound isoform	RCA			PTHR11100:SF20	PRO-NEUREGULIN-2, MEMBRANE-BOUND ISOFORM-RELATED
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IDA	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00021	FGF signaling pathway	P00632	Akt	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	IGI	95181376	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	MONDO|Ensembl=ENSMODG00000005993|UniProtKB=F6SL91	Uncharacterized protein	ISS			PTHR23409:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 B
P00012	Cadherin signaling pathway	P00474	Wnt	MONDO|Ensembl=ENSMODG00000013820|UniProtKB=F6SF10	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	3035212	PubMed	PTHR24070:SF385	GTPASE HRAS
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	TAS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00056	VEGF signaling pathway	P01411	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P02746	Heme biosynthesis	P02981	Glutamate-1-semialdehyde aminotransferase	PSEAE|EnsemblGenome=PA3977|UniProtKB=P48247	Glutamate-1-semialdehyde 2,1-aminomutase	ISS			PTHR43713:SF3	GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CAEEL|WormBase=WBGene00013338|UniProtKB=Q6BEQ0	Ligand-Gated ion Channel	IC			PTHR18945:SF520	LIGAND-GATED ION CHANNEL
P00005	Angiogenesis	P00193	SOS-1	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02785	Valine biosynthesis	P03217	Dihydroxy isovalerate reductoisomerase	YEAST|SGD=S000004347|UniProtKB=P06168	Ketol-acid reductoisomerase, mitochondrial	ISS			PTHR21371:SF13	KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL
P00056	VEGF signaling pathway	P01407	Erk	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05731	GABA-B receptor II signaling	P05754	Ggamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00056	VEGF signaling pathway	P01417	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00256	PLC-gamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	TAKRU|Ensembl=ENSTRUG00000006134|UniProtKB=H2SR71	Serine/threonine-protein phosphatase	ISS	8392016	PubMed	PTHR11668:SF191	SERINE/THREONINE-PROTEIN PHOSPHATASE
P00056	VEGF signaling pathway	P01414	PLC-gamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00019	Endothelin signaling pathway	P00586	Gq	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00556	PLCgamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IGI	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00010	B cell activation	P00391	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	RAT|RGD=1560083|UniProtKB=D3ZZK7	Protein Myo3a	ISS	22028976	PubMed	PTHR13140:SF387	MYOSIN-IIIA
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=1346347|UniProtKB=Q9WVS8	Mitogen-activated protein kinase 7	IPI	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00029	Huntington disease	P00780	Microtubule	DICDI|dictyBase=DDB_G0269196|UniProtKB=P32256	Tubulin beta chain	IDA	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	HUMAN|HGNC=10485|UniProtKB=Q15413	Ryanodine receptor 3	ISS	15226293	PubMed	PTHR13715:SF16	RYANODINE RECEPTOR 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00057	Wnt signaling pathway	P01465	Ggamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00005	Angiogenesis	P00211	GSK3beta	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	7667318	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MOUSE|MGI=MGI=109165|UniProtKB=Q61012	Guanine nucleotide-binding protein G(T) subunit gamma-T1	ISS	3100519	PubMed	PTHR13809:SF26	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT GAMMA-T1
P00060	Ubiquitin proteasome pathway	P01491	E2	SCLS1|EnsemblGenome=SS1G_11173|UniProtKB=A7F0Q4	Ubiquitin-conjugating enzyme E2	ISS			PTHR24068:SF74	FI16911P1-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PHYPA|Gene=PHYPADRAFT_109052|UniProtKB=A9TZ58	Actin 5	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00060	Ubiquitin proteasome pathway	P01490	E3	HUMAN|HGNC=12496|UniProtKB=Q05086	Ubiquitin-protein ligase E3A	ISS			PTHR11254:SF301	UBIQUITIN-PROTEIN LIGASE E3A
P00010	B cell activation	P00367	NFAT	RAT|RGD=1308692|UniProtKB=A0A0G2JTY4	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 (Predicted), isoform CRA_b	ISS	9133421	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00057	Wnt signaling pathway	P01428	Frizzled	DANRE|ZFIN=ZDB-GENE-990415-224|UniProtKB=F1QBI2	Uncharacterized protein	IDA	8717036	PubMed	PTHR11309:SF34	FRIZZLED-2
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	PANTR|Ensembl=ENSPTRG00000003128|UniProtKB=H2Q2V4	Uncharacterized protein	ISS	2137198	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00010	B cell activation	P00373	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01444	Wnt	RAT|RGD=1307015|UniProtKB=D3ZRW5	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00059	p53 pathway	P01486	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01202	p85	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P02768	Proline biosynthesis	P03114	Glutamyl kinase	YEAST|SGD=S000002708|UniProtKB=P32264	Glutamate 5-kinase	ISS			PTHR43654:SF3	GLUTAMATE 5-KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	RAT|RGD=619966|UniProtKB=F1LQT1	Adenylate cyclase 7	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00004	Alzheimer disease-presenilin pathway	P00170	Aph-1	XENTR|Xenbase=XB-GENE-921428|UniProtKB=Q5EB22	Anterior pharynx defective 1 homolog A	ISS	12110170	PubMed	PTHR12889:SF3	GAMMA-SECRETASE SUBUNIT APH-1A
P04397	p53 pathway by glucose deprivation	P04640	p53	ORNAN|Ensembl=ENSOANG00000013795|UniProtKB=F7DUR2	Uncharacterized protein (Fragment)	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IDA	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	IC	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00047	PDGF signaling pathway	P01153	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00029	Huntington disease	P00790	beta-Tubulin	DROME|FlyBase=FBgn0052396|UniProtKB=Q9VRX3	Probable tubulin beta chain CG32396	TAS	12932731	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00010	B cell activation	P00398	IP3R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	IGI	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	DANRE|ZFIN=ZDB-GENE-051202-2|UniProtKB=Q6ZM67	Uncharacterized protein	ISS	11554554	PubMed	PTHR44391:SF3	SUBFAMILY NOT NAMED
P00049	Parkinson disease	P01208	Hsp70	AQUAE|EnsemblGenome=aq_996|UniProtKB=O67118	Chaperone protein DnaK	IDA	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P00036	Interleukin signaling pathway	P00986	eNOS	HUMAN|HGNC=7876|UniProtKB=P29474	Nitric oxide synthase, endothelial	ISS	22462730	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	PANTR|Ensembl=ENSPTRG00000004718|UniProtKB=H2Q5I0	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	CAEEL|WormBase=WBGene00006390|UniProtKB=Q7YTH5	TAF (TBP-associated transcription factor) family	ISS	604905	OMIM	PTHR12321:SF78	TAF  TBP-ASSOCIATED TRANSCRIPTION FACTOR  FAMILY
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	DANRE|ZFIN=ZDB-GENE-030616-162|UniProtKB=F1R3G4	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF328	MYOSIN-10
P00057	Wnt signaling pathway	P01443	Phospholipase C	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	IDA	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00049	Parkinson disease	P01227	20S proteasome	CHICK|Ensembl=ENSGALG00000003046|UniProtKB=F1NC02	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF13	PROTEASOME SUBUNIT ALPHA TYPE-4
P00021	FGF signaling pathway	P00632	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01187	IR	DROME|FlyBase=FBgn0283499|UniProtKB=P09208	Insulin-like receptor	TAS	6754360	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00054	Toll receptor signaling pathway	P01352	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00236	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00310	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IDA	96009592	PubMed	PTHR10048:SF14	PI-3 KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	BOVIN|Ensembl=ENSBTAG00000017616|UniProtKB=A5PJR4	Adenylosuccinate synthetase isozyme 1	ISS	10636885	PubMed	PTHR11846:SF2	ADENYLOSUCCINATE SYNTHETASE ISOZYME 1
P00010	B cell activation	P00398	IP3R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	RCA	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00398	IP3R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P02746	Heme biosynthesis	P02975	Uroporphyrinogen decarboxylase	RHOBA|EnsemblGenome=RB7803|UniProtKB=Q7UN37	Uroporphyrinogen decarboxylase	ISS			PTHR21091:SF2	UROPORPHYRINOGEN DECARBOXYLASE
P00005	Angiogenesis	P00219	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	BOVIN|Ensembl=ENSBTAG00000006189|UniProtKB=P63258	Actin, cytoplasmic 2	ISS	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00019	Endothelin signaling pathway	P00572	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00047	PDGF signaling pathway	P01154	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	3035212	PubMed	PTHR24070:SF385	GTPASE HRAS
P00021	FGF signaling pathway	P00627	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	21150461	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00021	FGF signaling pathway	P00642	MEK1-2	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00020	FAS signaling pathway	P00601	c-Jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	ORNAN|Ensembl=ENSOANG00000007488|UniProtKB=F6RH86	Uncharacterized protein	ISS			PTHR13140:SF317	MYOSIN-9
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05913	Enkephalin release	P05974	G-Protein (i)	SCLS1|EnsemblGenome=SS1G_03482|UniProtKB=A7EDU2	Guanine nucleotide-binding protein beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	RAT|RGD=1595475|UniProtKB=D4AAI1	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF26	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT GAMMA-T1
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	IDA	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	SCHPO|PomBase=SPCC1223.08c|UniProtKB=P36591	Dihydrofolate reductase	ISS			PTHR22778:SF16	DIHYDROFOLATE REDUCTASE
P02781	Threonine biosynthesis	P03192	Aspartate semialdehyde dehydrogenase	RHOBA|EnsemblGenome=RB9795|UniProtKB=Q7UL17	Aspartate-semialdehyde dehydrogenase	ISS			PTHR10174:SF2	ASPARTATE-SEMIALDEHYDE DEHYDROGENASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	90172230	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P01485	p53	MOUSE|MGI=MGI=1330810|UniProtKB=O88898	Tumor protein 63	TAS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	MACMU|Ensembl=ENSMMUG00000007096|UniProtKB=F7ERG6	G protein-activated inward rectifier potassium channel 1	ISS			PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00475	Frizzled	MACMU|Ensembl=ENSMMUG00000013656|UniProtKB=F7GI70	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF126	FRIZZLED-5
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P06959	CCKR signaling map	P07094	EIF4E	HUMAN|HGNC=3287|UniProtKB=P06730	Eukaryotic translation initiation factor 4E	RCA	19339977	PubMed	PTHR11960:SF14	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CHLRE|EnsemblGenome=CHLREDRAFT_193901|UniProtKB=Q9FXT7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	CANLF|Ensembl=ENSCAFG00000003604|UniProtKB=E2R5G6	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF245	RAS-RELATED PROTEIN R-RAS
P00019	Endothelin signaling pathway	P00591	PLCbeta	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	HUMAN|HGNC=6693|UniProtKB=Q9NZR2	Low-density lipoprotein receptor-related protein 1B	IDA	11907044	PubMed	PTHR44025:SF7	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	CANLF|Ensembl=ENSCAFG00000010787|UniProtKB=E2R3W6	Uncharacterized protein	ISS	2137198	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	IDA	11360179	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01076	CAT	RAT|RGD=1304627|UniProtKB=P32738	Choline O-acetyltransferase	ISS	92155737	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	NEUCR|EnsemblGenome=EFNCRG00000004240|UniProtKB=Q01386	cAMP-dependent protein kinase regulatory subunit	IC	176892	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00318	PKCs	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01444	Wnt	RAT|RGD=1597195|UniProtKB=D4A9J2	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00053	T cell activation	P01331	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00034	Integrin signalling pathway	P00924	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IPI	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00774	Dynein complex	PANTR|Ensembl=ENSPTRG00000030689|UniProtKB=H2R986	Uncharacterized protein	ISS	9454836	PubMed	PTHR11886:SF52	DYNEIN LIGHT CHAIN 1, CYTOPLASMIC
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	CAEEL|WormBase=WBGene00011283|UniProtKB=Q22033	Uncharacterized protein	IDA	10617630	PubMed	PTHR11909:SF19	ASATOR, ISOFORM D
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00018	EGF receptor signaling pathway	P00556	PLCgamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IGI	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00029	Huntington disease	P00776	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	8837781	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00007	Axon guidance mediated by semaphorins	P00340	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00053	T cell activation	P01300	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01310	Lck	RAT|RGD=2994|UniProtKB=Q01621	Proto-oncogene tyrosine-protein kinase LCK	ISS	1505025	PubMed	PTHR24418:SF39	TYROSINE-PROTEIN KINASE LCK
P00059	p53 pathway	P04609	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00547	PP2A	MONDO|Ensembl=ENSMODG00000002945|UniProtKB=F6PKB8	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01453	Ebi	MACMU|Ensembl=ENSMMUG00000019597|UniProtKB=F7B9D1	Uncharacterized protein	ISS	11389839	PubMed	PTHR22846:SF40	F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN TBL1XR1
P00025	Hedgehog signaling pathway	P00682	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00807	Actin	XENTR|Xenbase=XB-GENE-493937|UniProtKB=Q5M8T9	Actin, alpha 2, smooth muscle, aorta	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00021	FGF signaling pathway	P00628	JNK1-3	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS			PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	TAS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00981	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ARATH|TAIR=AT2G42090|UniProtKB=P93738	Putative actin-9	IC	11889126	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00021	FGF signaling pathway	P00638	PLCgamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00019	Endothelin signaling pathway	P00568	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02754	Methylcitrate cycle	P03028	Aconitase	DROME|FlyBase=FBgn0024958|UniProtKB=Q9VCV4	Aconitate hydratase	ISS			PTHR11670:SF1	ACONITATE HYDRATASE
P00048	PI3 kinase pathway	P01185	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	DANRE|ZFIN=ZDB-GENE-040108-2|UniProtKB=Q1RLX8	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF775	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000012778|UniProtKB=H2QJ75	Phosphoinositide phospholipase C	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00029	Huntington disease	P00780	Microtubule	THAPS|Gene=Thaps8069|UniProtKB=B8C8B4	Tubulin beta	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	11591316	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	MOUSE|MGI=MGI=98181|UniProtKB=P11157	Ribonucleoside-diphosphate reductase subunit M2	ISS			PTHR23409:SF20	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00037	Ionotropic glutamate receptor pathway	P01001	KA4	RAT|RGD=2734|UniProtKB=Q01812	Glutamate receptor ionotropic, kainate 4	IEA	1648176	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	RAT|RGD=2246|UniProtKB=Q07652	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	11976940	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P05918	p38 MAPK pathway	P06024	eIF4E	CANLF|Ensembl=ENSCAFG00000010307|UniProtKB=F1PSC3	Uncharacterized protein	ISS			PTHR11960:SF14	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E
P00005	Angiogenesis	P00195	APC	PANTR|Ensembl=ENSPTRG00000017135|UniProtKB=H2QRB5	Adenomatous polyposis coli	ISS	8259518	PubMed	PTHR12607:SF11	ADENOMATOUS POLYPOSIS COLI PROTEIN
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	PANTR|Ensembl=ENSPTRG00000005528|UniProtKB=H2Q705	Nucleoside diphosphate kinase	ISS			PTHR11349:SF68	NUCLEOSIDE DIPHOSPHATE KINASE-RELATED
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=3595|UniProtKB=Q14517	Protocadherin Fat 1	IDA	8120095	PubMed	PTHR24026:SF42	PROTOCADHERIN FAT 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00018	EGF receptor signaling pathway	P00547	PP2A	RAT|RGD=1305657|UniProtKB=A0A0G2JTA1	Protein Ppp2r5e	ISS	10092233	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	MACMU|Ensembl=ENSMMUG00000022513|UniProtKB=F6YNZ0	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00046	Oxidative stress response	P01129	JNK1/2	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02758	Ornithine degradation	P03055	Aminobutyraldehyde dehydrogenase	ECOLI|EcoGene=EG13766|UniProtKB=P77674	Gamma-aminobutyraldehyde dehydrogenase	RCA			PTHR11699:SF109	GAMMA-AMINOBUTYRALDEHYDE DEHYDROGENASE
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	MACMU|Ensembl=ENSMMUG00000018790|UniProtKB=F6ZPM8	Serine/threonine-protein kinase receptor	ISS	9395284	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P00002	Alpha adrenergic receptor signaling pathway	P00078	Alpha1A/1B/1C	MOUSE|MGI=MGI=106673|UniProtKB=P97714	Alpha-1D adrenergic receptor	IC	6323229	PubMed	PTHR24248:SF14	ALPHA-1D ADRENERGIC RECEPTOR
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000000843|UniProtKB=H2QZN8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	CHICK|Ensembl=ENSGALG00000002003|UniProtKB=F1P3H0	Receptor protein serine/threonine kinase	TAS	9395284	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P00021	FGF signaling pathway	P00645	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12176041	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	XENTR|Xenbase=XB-GENE-1010483|UniProtKB=F7AF72	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	MACMU|Ensembl=ENSMMUG00000002658|UniProtKB=F7CB14	Uncharacterized protein	ISS	2137198	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	14744428	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P06959	CCKR signaling map	P07187	Beta-arrestin-1/2	HUMAN|HGNC=712|UniProtKB=P32121	Beta-arrestin-2	RCA	21156802	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P05915	Opioid proenkephalin pathway	P05991	Enkephalin	MOUSE|MGI=MGI=104629|UniProtKB=P22005	Proenkephalin-A	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00029	Huntington disease	P00807	Actin	DICDI|dictyBase=DDB_G0275023|UniProtKB=Q553U6	Putative actin-22	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=1953|UniProtKB=P08173	Muscarinic acetylcholine receptor M4	IDA	10069496	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00839	SHIP	CANLF|Ensembl=ENSCAFG00000005743|UniProtKB=F1PNY0	Uncharacterized protein	ISS	9824312	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00009	Axon guidance mediated by netrin	P00366	Rac	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IDA	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00036	Interleukin signaling pathway	P00973	PKB	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00379	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00010	B cell activation	P00398	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02722	Acetate utilization	P02802	Phosphate acetyltransferase	BACSU|EnsemblGenome=BSU24090|UniProtKB=P54530	Probable phosphate butyryltransferase	ISS			PTHR43356:SF2	SUBFAMILY NOT NAMED
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00009	Axon guidance mediated by netrin	P00366	Rac	CHICK|Ensembl=ENSGALG00000002859|UniProtKB=F6UBD2	Uncharacterized protein	ISS	15470041	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00005	Angiogenesis	P00208	MEKK1	RAT|RGD=620966|UniProtKB=Q62925	Mitogen-activated protein kinase kinase kinase 1	ISS	8643568	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00810	GAPDH	DROME|FlyBase=FBgn0001091|UniProtKB=P07486	Glyceraldehyde-3-phosphate dehydrogenase 1	ISS			PTHR10836:SF52	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED
P00019	Endothelin signaling pathway	P00591	PLCbeta	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00057	Wnt signaling pathway	P01435	SWI/SNF	RAT|RGD=1304850|UniProtKB=A0A0G2K9D6	Protein Smarcc1	ISS	11532957	PubMed	PTHR12802:SF9	SWI/SNF COMPLEX SUBUNIT SMARCC1
P04397	p53 pathway by glucose deprivation	P04641	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00833	RGS	RAT|RGD=1305515|UniProtKB=F1M0G0	Protein Rgs17	ISS	21240406	PubMed	PTHR10845:SF196	REGULATOR OF G-PROTEIN SIGNALING 17
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IGI	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00570	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	7925653	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00023	General transcription regulation	P00666	TFIIE	HUMAN|HGNC=4651|UniProtKB=P29084	Transcription initiation factor IIE subunit beta	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00111	C99	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00010	B cell activation	P00373	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	9332390	PubMed	PTHR10202:SF13	PRESENILIN-2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-040426-2427|UniProtKB=F1Q6C0	Uncharacterized protein (Fragment)	ISS	3037538	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04546	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00139	E-cadherin transmembrane fragment	MOUSE|MGI=MGI=88354|UniProtKB=P09803	Cadherin-1	IDA	8120095	PubMed	PTHR24027:SF319	CADHERIN-1
P02773	S-adenosylmethionine biosynthesis	P03142	Cobalamin-dependent homocysteine transmethylase	STRCO|Gene=CAC18788|UniProtKB=Q9EWH3	Putative methionine synthase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00048	PI3 kinase pathway	P01202	p85	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DICDI|dictyBase=DDB_G0269234|UniProtKB=P07830	Major actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	HUMAN|HGNC=132|UniProtKB=P60709	Actin, cytoplasmic 1	IC	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00029	Huntington disease	P00780	Microtubule	MOUSE|MGI=MGI=107812|UniProtKB=P99024	Tubulin beta-5 chain	IDA	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00010	B cell activation	P00371	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00219	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00010	B cell activation	P00373	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00018	EGF receptor signaling pathway	P00547	PP2A	BOVIN|Ensembl=ENSBTAG00000007061|UniProtKB=Q08DP7	Protein phosphatase 2, regulatory subunit B', beta isoform	ISS	96161994	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P05916	Opioid prodynorphin pathway	P06002	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	ECOLI|EcoGene=EG12381|UniProtKB=P37146	Ribonucleoside-diphosphate reductase 2 subunit beta	ISS			PTHR23409:SF32	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT BETA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	BOVIN|Ensembl=ENSBTAG00000014583|UniProtKB=P62157	Calmodulin	ISS	9753452	PubMed	PTHR23050:SF335	CALMODULIN, STRIATED MUSCLE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	RCA	188830	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00163	Erb-B4 C-terminal fragment	CHICK|Ensembl=ENSGALG00000003126|UniProtKB=F1P258	Receptor protein-tyrosine kinase	ISS	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	IC	14684598	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00021	FGF signaling pathway	P00644	p38	CAEEL|WormBase=WBGene00004056|UniProtKB=Q8MXI4	Mitogen-activated protein kinase pmk-2	ISS	10514528	PubMed	PTHR24055:SF154	MITOGEN-ACTIVATED PROTEIN KINASE PMK-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	RAT|RGD=2248|UniProtKB=P54287	Voltage-dependent L-type calcium channel subunit beta-3	IC			PTHR11824:SF8	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-3
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	PANTR|Ensembl=ENSPTRG00000024129|UniProtKB=H2R176	Uncharacterized protein	ISS			PTHR10937:SF2	GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE  ISOMERIZING  1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	DANRE|ZFIN=ZDB-GENE-000502-1|UniProtKB=Q1RLX1	Receptor protein serine/threonine kinase	TAS	9395284	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS			PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P06587	Nicotine pharmacodynamics pathway	P06605	KCNK3/9	MOUSE|MGI=MGI=1100509|UniProtKB=O35111	Potassium channel subfamily K member 3	RCA	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	DANRE|ZFIN=ZDB-GENE-030407-1|UniProtKB=F1QC27	Uncharacterized protein	ISS			PTHR11681:SF14	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01159	SOS	CHICK|Ensembl=ENSGALG00000013224|UniProtKB=F1NMA4	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00005	Angiogenesis	P00218	STAT1	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	ISS	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000000985|UniProtKB=F6VRS9	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-9966|UniProtKB=Q6TH03	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00059	p53 pathway	P04609	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01411	Ras	MONDO|Gene=KRAS|UniProtKB=Q07983	GTPase KRas	ISS	99084794	PubMed	PTHR24070:SF186	GTPASE KRAS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01434	sFRP	XENTR|Xenbase=XB-GENE-488230|UniProtKB=F7EN59	Uncharacterized protein (Fragment)	ISS	9096311	PubMed	PTHR11309:SF87	SECRETED FRIZZLED-RELATED PROTEIN 1
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	ENTHI|EnsemblGenome=EHI_160930|UniProtKB=O15635	Cysteine synthase A, putative	ISS			PTHR10314:SF131	CYSTEINE SYNTHASE 1
P00019	Endothelin signaling pathway	P00572	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IGI	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	RAT|RGD=620314|UniProtKB=B0LPN4	Ryanodine receptor 2	ISS	15226293	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01161	Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	ISS	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00024	Glycolysis	P00677	Hexokinase	RAT|RGD=2797|UniProtKB=P27881	Hexokinase-2	RCA			PTHR19443:SF4	HEXOKINASE-2
P00045	Notch signaling pathway	P01120	NIcs	HUMAN|HGNC=7882|UniProtKB=Q04721	Neurogenic locus notch homolog protein 2	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000025373|UniProtKB=F6ZZG9	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04398	p53 pathway feedback loops 2	G04712	P21	RAT|RGD=69328|UniProtKB=Q64315	Cyclin-dependent kinase inhibitor 1A	IGI	7774811	PubMed	PTHR10265:SF16	CYCLIN-DEPENDENT KINASE INHIBITOR 1
P00021	FGF signaling pathway	P00629	PP2A	IXOSC|EnsemblGenome=ISCW014549|UniProtKB=B7QGY5	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	CANAL|CGD=CAL0000175344|UniProtKB=Q59Q46	Inosine-5'-monophosphate dehydrogenase	ISS			PTHR11911:SF111	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE
P00045	Notch signaling pathway	P01110	Presenilin	MACMU|Ensembl=ENSMMUG00000010173|UniProtKB=F7AGU8	Presenilin	ISS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00757	beta-arrestin	RAT|RGD=3619|UniProtKB=P15887	S-arrestin	IDA	11742073	PubMed	PTHR11792:SF15	S-ARRESTIN
P00049	Parkinson disease	P01211	ERK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	IDA	10514528	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CANLF|Ensembl=ENSCAFG00000008760|UniProtKB=E2RTG8	Protein Wnt	ISS	14644163	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00010	B cell activation	P00383	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IDA	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	XENTR|Xenbase=XB-GENE-957124|UniProtKB=F7BDN8	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00048	PI3 kinase pathway	P01185	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	RAT|RGD=2742|UniProtKB=P23385	Metabotropic glutamate receptor 1	ISS	7476890	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	CHICK|Ensembl=ENSGALG00000002932|UniProtKB=O57535	Nucleoside diphosphate kinase	ISS			PTHR11349:SF57	NUCLEOSIDE DIPHOSPHATE KINASE B
P02738	De novo purine biosynthesis	P02899	GMP synthase	AQUAE|EnsemblGenome=aq_236|UniProtKB=O66601	GMP synthase [glutamine-hydrolyzing]	ISS			PTHR11922:SF2	GMP SYNTHASE  GLUTAMINE-HYDROLYZING
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	MONDO|Ensembl=ENSMODG00000013970|UniProtKB=F6R6X5	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IDA	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CAEBR|Gene=CBG02162|UniProtKB=A8WS33	Protein CBG02162	ISS	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P05731	GABA-B receptor II signaling	P05755	Gbeta	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00018	EGF receptor signaling pathway	P00561	STAT	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	ISS	12191995	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P05913	Enkephalin release	P05974	G-Protein (i)	CANLF|Ensembl=ENSCAFG00000015662|UniProtKB=E2RHY4	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00036	Interleukin signaling pathway	P00970	Interleukin	CANLF|Ensembl=ENSCAFG00000000855|UniProtKB=Q95J76	Interleukin-5	IDA	11440633	PubMed	PTHR45421:SF1	INTERLEUKIN-5
P06664	Gonadotropin-releasing hormone receptor pathway	G06891	Junc	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	RCA	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00047	PDGF signaling pathway	P01165	SRF	HUMAN|HGNC=11291|UniProtKB=P11831	Serum response factor	ISS	15170389	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P05918	p38 MAPK pathway	P06029	p38beta	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00045	Notch signaling pathway	P01099	Notch	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	1764995	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	HUMAN|HGNC=3023|UniProtKB=P14416	D(2) dopamine receptor	ISS	11861492	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00006	Apoptosis signaling pathway	P00269	MAPK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00053	T cell activation	P01300	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	METJA|EnsemblGenome=MJ_1616|UniProtKB=Q59011	Inosine-5'-monophosphate dehydrogenase	ISS			PTHR11911:SF6	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	BOVIN|Ensembl=ENSBTAG00000005464|UniProtKB=E1B9K3	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00055	Transcription regulation by bZIP transcription factor	P01392	TFIIH complex	MONDO|Ensembl=ENSMODG00000006540|UniProtKB=F7BVJ4	Uncharacterized protein	ISS			PTHR12856:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 1
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00010	B cell activation	P00384	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	BOVIN|Ensembl=ENSBTAG00000017380|UniProtKB=E1BKQ6	Uncharacterized protein	ISS			PTHR13140:SF421	UNCONVENTIONAL MYOSIN-XVIIIA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00973	PKB	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MONDO|Ensembl=ENSMODG00000020977|UniProtKB=F6S5B1	Uncharacterized protein (Fragment)	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	18021322	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	HUMAN|HGNC=5287|UniProtKB=P28222	5-hydroxytryptamine receptor 1B	ISS	12441358	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P04393	Ras Pathway	P04552	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	HUMAN|HGNC=7849|UniProtKB=P15531	Nucleoside diphosphate kinase A	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P00005	Angiogenesis	P00219	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	ARATH|TAIR=AT5G58690|UniProtKB=Q944C2	Phosphoinositide phospholipase C 5	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	PANTR|Ensembl=ENSPTRG00000022029|UniProtKB=H2QYT2	Uncharacterized protein	ISS	10487978	PubMed	PTHR10749:SF4	PHOSPHORYLASE B KINASE REGULATORY SUBUNIT ALPHA, SKELETAL MUSCLE ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	ISS	14684598	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P06664	Gonadotropin-releasing hormone receptor pathway	P06728	Caln	MOUSE|MGI=MGI=107164|UniProtKB=P63328	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	RCA	12015605	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	2837282	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00019	Endothelin signaling pathway	P00570	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00547	PP2A	CANLF|Ensembl=ENSCAFG00000014047|UniProtKB=F1PV54	Uncharacterized protein	ISS	11531413	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00474	Wnt	BOVIN|Ensembl=ENSBTAG00000014291|UniProtKB=A6H6X8	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	BOVIN|Ensembl=ENSBTAG00000037726|UniProtKB=P10895	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	12860966	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00021	FGF signaling pathway	P00632	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=13829|UniProtKB=Q9GZT5	Protein Wnt-10a	TAS	8717036	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00056	VEGF signaling pathway	P01423	p38MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00053	T cell activation	P01306	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P05730	Endogenous cannabinoid signaling	P05751	Galpha	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04397	p53 pathway by glucose deprivation	P04641	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00564	Rac	DICPU|Gene=DICPUDRAFT_92985|UniProtKB=F1A084	Putative uncharacterized protein rac1A	ISS	12932731	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00007	Axon guidance mediated by semaphorins	P00331	PAK	MOUSE|MGI=MGI=1339975|UniProtKB=O88643	Serine/threonine-protein kinase PAK 1	IDA	14580336	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00029	Huntington disease	P00778	NMDA receptor	CAEBR|Gene=CBG02401|UniProtKB=A8WUE7	Protein CBR-NMR-1	ISS	11554554	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	MONDO|Ensembl=ENSMODG00000011791|UniProtKB=F7CBU9	Phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00562	p38	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05730	Endogenous cannabinoid signaling	P05746	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00047	PDGF signaling pathway	P01142	p90RSK	MONDO|Ensembl=ENSMODG00000006241|UniProtKB=F7FRY0	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00059	p53 pathway	P04633	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04397	p53 pathway by glucose deprivation	P04644	TSC2	PANTR|Ensembl=ENSPTRG00000031311|UniProtKB=H2R1U8	Uncharacterized protein	ISS	12150915	PubMed	PTHR10063:SF0	TUBERIN
P00049	Parkinson disease	P01230	Src kinase	RAT|RGD=3977|UniProtKB=F1LM93	Tyrosine-protein kinase Yes	IDA	11078745	PubMed	PTHR24418:SF90	TYROSINE-PROTEIN KINASE YES
P00005	Angiogenesis	P00194	Paxillin	HUMAN|HGNC=9718|UniProtKB=P49023	Paxillin	ISS	9182576	PubMed	PTHR24216:SF11	PAXILLIN
P04393	Ras Pathway	P04553	PAK	RAT|RGD=61953|UniProtKB=Q64303	Serine/threonine-protein kinase PAK 2	IDA	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P05913	Enkephalin release	P05974	G-Protein (i)	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	XENTR|Xenbase=XB-GENE-992519|UniProtKB=F6VS22	Uncharacterized protein	ISS	15328036	PubMed	PTHR43893:SF8	D 1B  DOPAMINE RECEPTOR
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DANRE|ZFIN=ZDB-GENE-010705-1|UniProtKB=Q90Z40	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MOUSE|MGI=MGI=1336171|UniProtKB=Q9DAS9	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00021	FGF signaling pathway	P00640	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	SCHMA|EnsemblGenome=Smp_028990|UniProtKB=G4VGS4	Serine/threonine-protein phosphatase	ISS	8392016	PubMed	PTHR11668:SF402	SERINE/THREONINE-PROTEIN PHOSPHATASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000010184|UniProtKB=F6SR09	Uncharacterized protein	ISS			PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00012	Cadherin signaling pathway	P00477	GSK3beta	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00036	Interleukin signaling pathway	P00965	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF31	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01414	PLC-gamma	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00057	Wnt signaling pathway	P01449	Nemo-like Kinase	TAKRU|Ensembl=ENSTRUG00000006607|UniProtKB=H2SUZ9	Mitogen-activated protein kinase	ISS	10683140	PubMed	PTHR24055:SF179	SERINE/THREONINE-PROTEIN KINASE NLK
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=98957|UniProtKB=P22724	Protein Wnt-4	TAS	8717036	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00020	FAS signaling pathway	P00620	CytochromeC	PSEAE|EnsemblGenome=PA4429|UniProtKB=Q9HVY6	Probable cytochrome c1	IGI	15163634	PubMed	PTHR10266:SF4	SUBFAMILY NOT NAMED
P05912	Dopamine receptor mediated signaling pathway	P05959	FLNA	ORNAN|Ensembl=ENSOANG00000011016|UniProtKB=F7D6Q6	Uncharacterized protein	ISS	11911837	PubMed	PTHR43998:SF6	FILAMIN-A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	IDA	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	MOUSE|MGI=MGI=105304|UniProtKB=P22272	Interleukin-6 receptor subunit alpha	ISS			PTHR23036:SF98	INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00010	B cell activation	P00402	Jnk	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00021	FGF signaling pathway	P00645	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IGI	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	PANTR|Ensembl=ENSPTRG00000002979|UniProtKB=H2Q2M8	Uncharacterized protein	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	SCHPO|PomBase=SPAC4A8.05c|UniProtKB=O14157	Myosin type-2 heavy chain 2	IC			PTHR13140:SF555	MYOSIN HEAVY CHAIN, MUSCLE
P00052	TGF-beta signaling pathway	P01284	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00055	Transcription regulation by bZIP transcription factor	P01390	TFIIA complex	DROME|FlyBase=FBgn0011289|UniProtKB=P52654	Transcription initiation factor IIA subunit 1	ISS	600519	OMIM	PTHR12694:SF8	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1
P04396	Vitamin D metabolism and pathway	P04604	FdxR	STRCO|Gene=CAB60462|UniProtKB=Q9RK35	Putative ferredoxin/ferredoxin-NADP reductase (Putative secreted protein)	ISS			PTHR11938:SF114	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00558	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00049	Parkinson disease	P01242	Casein kinase I	CAEEL|WormBase=WBGene00013709|UniProtKB=Q8WQ99	Casein kinase I gamma	IDA	11437445	PubMed	PTHR11909:SF155	GILGAMESH, ISOFORM L
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=98954|UniProtKB=P21552	Protein Wnt-2	IDA	11266476	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	BOVIN|Gene=DRD2|UniProtKB=P20288	D(2) dopamine receptor	ISS	1319557	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00019	Endothelin signaling pathway	P00570	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	ISS	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	CHICK|Ensembl=ENSGALG00000005518|UniProtKB=F1NTL1	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P06664	Gonadotropin-releasing hormone receptor pathway	P06805	MKK3/6	MOUSE|MGI=MGI=1346870|UniProtKB=P70236	Dual specificity mitogen-activated protein kinase kinase 6	RCA	8622669	PubMed	PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT3G45640|UniProtKB=Q39023	Mitogen-activated protein kinase 3	ISS	12787066	PubMed	PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05918	p38 MAPK pathway	P06034	MKK4	MACMU|Ensembl=ENSMMUG00000019842|UniProtKB=F7FU91	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00021	FGF signaling pathway	P00640	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	IGI	8700226	PubMed	PTHR10048:SF14	PI-3 KINASE
P00045	Notch signaling pathway	P01112	CoR	HUMAN|HGNC=24217|UniProtKB=Q86X95	Corepressor interacting with RBPJ 1	TAS	11112321	PubMed	PTHR13151:SF2	COREPRESSOR INTERACTING WITH RBPJ 1
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01318	PKC-theta	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00906	Rap1	PANTR|Ensembl=ENSPTRG00000005197|UniProtKB=A5A6J7	Ras-related protein Rap-1b	ISS	1904317	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	CANLF|Ensembl=ENSCAFG00000005945|UniProtKB=E2R8P1	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P04393	Ras Pathway	P04555	PDK	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	15531926	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00005	Angiogenesis	P00219	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04393	Ras Pathway	P04557	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00035	Interferon-gamma signaling pathway	P00956	SOCS	RAT|RGD=1304632|UniProtKB=D3ZS84	Protein Socs6	ISS	12645661	PubMed	PTHR44562:SF1	SUPPRESSOR OF CYTOKINE SIGNALING 6
P00021	FGF signaling pathway	P00632	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05918	p38 MAPK pathway	P06031	p38alpha	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	TAKRU|Ensembl=ENSTRUG00000012520|UniProtKB=H2U442	Uncharacterized protein	ISS			PTHR12458:SF8	CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20
P00047	PDGF signaling pathway	P01171	PLCgamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	HUMAN|HGNC=7567|UniProtKB=P12882	Myosin-1	ISS	10938134	PubMed	PTHR13140:SF484	MYOSIN-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IC	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	DROME|FlyBase=FBgn0010223|UniProtKB=Q05337	Guanine nucleotide-binding protein G(f) subunit alpha	ISS			PTHR10218:SF229	GUANINE NUCLEOTIDE-BINDING PROTEIN G F  SUBUNIT ALPHA
P02746	Heme biosynthesis	P02979	porphobilinogen synthase	HUMAN|HGNC=395|UniProtKB=P13716	Delta-aminolevulinic acid dehydratase	ISS			PTHR11458:SF0	DELTA-AMINOLEVULINIC ACID DEHYDRATASE
P00018	EGF receptor signaling pathway	P00560	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01227	20S proteasome	BOVIN|Ensembl=ENSBTAG00000003830|UniProtKB=P33672	Proteasome subunit beta type-3	ISS	12859888	PubMed	PTHR11599:SF62	PROTEASOME SUBUNIT BETA TYPE-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	XENTR|Xenbase=XB-GENE-999257|UniProtKB=F7CEX4	Uncharacterized protein	ISS	97228584	PubMed	PTHR11920:SF319	ADENYLATE CYCLASE TYPE 9
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	HUMAN|HGNC=3025|UniProtKB=P21917	D(4) dopamine receptor	ISS	2039532	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P04393	Ras Pathway	P04546	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01154	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=1309999|UniProtKB=Q922R0	cAMP-dependent protein kinase catalytic subunit PRKX	RCA	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00029	Huntington disease	P00807	Actin	BOVIN|Ensembl=ENSBTAG00000014614|UniProtKB=P62739	Actin, aortic smooth muscle	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00629	PP2A	MACMU|Ensembl=ENSMMUG00000004873|UniProtKB=F7ANY9	Uncharacterized protein	ISS	12110603	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	BOVIN|Gene=RGS9|UniProtKB=O46469	Regulator of G-protein signaling 9	IDA	8756726	PubMed	PTHR10845:SF170	REGULATOR OF G-PROTEIN SIGNALING 9
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00018	EGF receptor signaling pathway	P00561	STAT	HUMAN|HGNC=11362|UniProtKB=P42224	Signal transducer and activator of transcription 1-alpha/beta	IGI	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00010	B cell activation	P00374	Lyn	MOUSE|MGI=MGI=96892|UniProtKB=P25911	Tyrosine-protein kinase Lyn	IDA	11078745	PubMed	PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00011	Blood coagulation	P00455	GP IX	HUMAN|HGNC=4444|UniProtKB=P14770	Platelet glycoprotein IX	IDA	91071429	PubMed	PTHR22650:SF6	PLATELET GLYCOPROTEIN IX
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=14257|UniProtKB=Q8N6Y1	Protocadherin-20	IDA	8120095	PubMed	PTHR43912:SF7	PROTOCADHERIN-20
P00029	Huntington disease	P00768	Apaf-1	MACMU|Ensembl=ENSMMUG00000022404|UniProtKB=F6U0K7	Apoptotic protease-activating factor 1	ISS	10364241	PubMed	PTHR22845:SF5	APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
P00004	Alzheimer disease-presenilin pathway	P00131	HAC1	RAT|RGD=1310981|UniProtKB=D3ZQG6	Tripartite motif-containing protein 2	ISS			PTHR44028:SF2	TRIPARTITE MOTIF-CONTAINING PROTEIN 2
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	IDA	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02916	dTMP kinase	PSEAE|EnsemblGenome=PA2962|UniProtKB=Q9HZN8	Thymidylate kinase	ISS			PTHR10344:SF1	THYMIDYLATE KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04397	p53 pathway by glucose deprivation	P04641	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01288	FKBP12	BOVIN|Ensembl=ENSBTAG00000003409|UniProtKB=P68107	Peptidyl-prolyl cis-trans isomerase FKBP1B	ISS			PTHR10516:SF309	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	TAKRU|Ensembl=ENSTRUG00000010005|UniProtKB=H2TKG8	Uncharacterized protein	ISS	2106672	PubMed	PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01199	Galpha	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	AQUAE|EnsemblGenome=aq_111|UniProtKB=O66514	Glutamine synthetase	ISS			PTHR43407:SF1	LENGSIN
P00047	PDGF signaling pathway	P01160	IP3 receptor	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MONDO|Ensembl=ENSMODG00000024440|UniProtKB=F7DJJ2	Muscarinic acetylcholine receptor	ISS	8100450	PubMed	PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00036	Interleukin signaling pathway	P00973	PKB	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00048	PI3 kinase pathway	P01192	p110	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	15210700	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=1351344|UniProtKB=Q68ED2	Metabotropic glutamate receptor 7	ISS	9407094	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00016	Cytoskeletal regulation by Rho GTPase	P00513	Op18/stathmin	RAT|RGD=2992|UniProtKB=P13668	Stathmin	ISS	http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=3925	Website	PTHR10104:SF5	STATHMIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS			PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IDA	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05913	Enkephalin release	P05972	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00906	Rap1	TAKRU|Ensembl=ENSTRUG00000012649|UniProtKB=H2U503	Uncharacterized protein	ISS	8576107	PubMed	PTHR24070:SF200	RAS-RELATED PROTEIN RAP-2C
P00005	Angiogenesis	P00190	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P02738	De novo purine biosynthesis	P02889	dGDP kinase	HUMAN|HGNC=7850|UniProtKB=P22392	Nucleoside diphosphate kinase B	ISS			PTHR11349:SF57	NUCLEOSIDE DIPHOSPHATE KINASE B
P00001	Adrenaline and noradrenaline biosynthesis	P00070	VAT2	MACMU|Ensembl=ENSMMUG00000014817|UniProtKB=F6VXD8	Uncharacterized protein	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00010	B cell activation	P00367	NFAT	MOUSE|MGI=MGI=103296|UniProtKB=P97305	Nuclear factor of activated T-cells, cytoplasmic 3	IDA	12787506	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P05915	Opioid proenkephalin pathway	P05994	G-protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	ISS	10188796	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00007	Axon guidance mediated by semaphorins	P00331	PAK	MOUSE|MGI=MGI=1339975|UniProtKB=O88643	Serine/threonine-protein kinase PAK 1	IDA	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	ISS			PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00036	Interleukin signaling pathway	P00985	PDK1/2	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	IDA	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04397	p53 pathway by glucose deprivation	P04639	AMPK	HUMAN|HGNC=9377|UniProtKB=P54646	5'-AMP-activated protein kinase catalytic subunit alpha-2	ISS			PTHR24343:SF303	5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00046	Oxidative stress response	P01135	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	TAS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00012	Cadherin signaling pathway	P00470	F-actin	ENTHI|EnsemblGenome=EHI_107290|UniProtKB=B1N2P0	Actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000016097|UniProtKB=E1B9S9	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	BOVIN|Ensembl=ENSBTAG00000006143|UniProtKB=E1BNX4	Uncharacterized protein	ISS	608972	OMIM	PTHR22952:SF24	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04657	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	HUMAN|HGNC=4587|UniProtKB=Q14957	Glutamate receptor ionotropic, NMDA 2C	ISS	11319238	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00053	T cell activation	P01307	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00045	Notch signaling pathway	P01118	Numb	DROME|FlyBase=FBgn0002973|UniProtKB=P16554	Protein numb	TAS	8755472	PubMed	PTHR11232:SF45	PROTEIN NUMB
P00036	Interleukin signaling pathway	P00996	STAT	MACMU|Ensembl=ENSMMUG00000010705|UniProtKB=F7G8V4	Signal transducer and activator of transcription	ISS	8732682	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00038	JAK/STAT signaling pathway	P01027	STAT	DANRE|ZFIN=ZDB-GENE-980526-499|UniProtKB=Q6P943	Signal transducer and activator of transcription	ISS	99348060	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00047	PDGF signaling pathway	P01162	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	MOUSE|MGI=MGI=102806|UniProtKB=P27038	Activin receptor type-2A	TAS	9395284	PubMed	PTHR23255:SF64	ACTIVIN RECEPTOR TYPE-2A
P05914	Nicotine degradation	P05984	CYP2A6	MACMU|Ensembl=ENSMMUG00000021068|UniProtKB=F7GYG0	Uncharacterized protein	ISS			PTHR24300:SF293	CYTOCHROME P450 2A6-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	8946911	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000007445|UniProtKB=F6SWI4	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00036	Interleukin signaling pathway	P00981	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	TAS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00010	B cell activation	P00371	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00013	Cell cycle	P00480	Proteasome	MOUSE|MGI=MGI=1345192|UniProtKB=Q9WVJ2	26S proteasome non-ATPase regulatory subunit 13	ISS	10225435	PubMed	PTHR10539:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00560	Raf-1	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS			PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05916	Opioid prodynorphin pathway	P06002	G-protein	CANLF|Ensembl=ENSCAFG00000028654|UniProtKB=J9P702	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00021	FGF signaling pathway	P00645	Rac	ORYSJ|EnsemblGenome=OS06G0234200|UniProtKB=Q67VP4	Rac-like GTP-binding protein 4	ISS	12932731	PubMed	PTHR24072:SF174	SUBFAMILY NOT NAMED
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00018	EGF receptor signaling pathway	P00557	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	ISS	12660731	PubMed	PTHR10048:SF14	PI-3 KINASE
P00036	Interleukin signaling pathway	P00962	ELK	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	3183861	gi	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00057	Wnt signaling pathway	P01471	alpha-catenin	DANRE|Ensembl=ENSDARG00000024785|UniProtKB=B7ZC77	Catenin alpha-2	ISS	9362521	PubMed	PTHR18914:SF29	CATENIN ALPHA-2
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00013	Cell cycle	P00480	Proteasome	MACMU|Ensembl=ENSMMUG00000012685|UniProtKB=F7E2B2	Uncharacterized protein	ISS	9218537	PubMed	PTHR10660:SF4	PROTEASOME ACTIVATOR COMPLEX SUBUNIT 3
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00057	Wnt signaling pathway	P01451	Galpha	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1170702	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	ORYSJ|EnsemblGenome=OS06G0154500|UniProtKB=Q84UI5	Mitogen-activated protein kinase 1	ISS			PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	MOUSE|MGI=MGI=109527|UniProtKB=Q9R244	Short transient receptor potential channel 2	IDA	11055438	PubMed	PTHR10117:SF6	PROTEIN XNTRPC-RELATED
P00037	Ionotropic glutamate receptor pathway	P00999	PSD95	HUMAN|HGNC=15474|UniProtKB=Q9Y566	SH3 and multiple ankyrin repeat domains protein 1	ISS	20020275	PubMed	PTHR24135:SF3	SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN 1
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000011078|UniProtKB=F7FX79	Protocadherin-19 isoform c	ISS	8120095	PubMed	PTHR24028:SF40	PROTOCADHERIN-19
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	PLAF7|EnsemblGenome=PFD0830w|UniProtKB=Q8I1R6	Bifunctional dihydrofolate reductase-thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P04393	Ras Pathway	P04570	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P02741	Flavin biosynthesis	P02935	GTP cyclohydrolase	SCHPO|PomBase=SPAC1002.19|UniProtKB=Q9US41	Uracil-regulated protein 1	ISS			PTHR21327:SF16	SUBFAMILY NOT NAMED
P00012	Cadherin signaling pathway	P00475	Frizzled	MOUSE|MGI=MGI=1313278|UniProtKB=Q9R216	Frizzled-9	IDA	11212302	PubMed	PTHR11309:SF79	FRIZZLED-9
P02741	Flavin biosynthesis	P02935	GTP cyclohydrolase	YEAST|SGD=S000000129|UniProtKB=P38066	GTP cyclohydrolase-2	ISS			PTHR21327:SF13	GTP CYCLOHYDROLASE-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00045	Notch signaling pathway	P01103	Next	HUMAN|HGNC=6188|UniProtKB=P78504	Protein jagged-1	IGI	12826675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00018	EGF receptor signaling pathway	P00542	EGFR	CANLF|Gene=ERBB2|UniProtKB=O18735	Receptor tyrosine-protein kinase erbB-2	ISS	2575867	gi	PTHR24416:SF137	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00111	C99	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00021	FGF signaling pathway	P00644	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IGI	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00047	PDGF signaling pathway	P01160	IP3 receptor	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00053	T cell activation	P01321	SLP-76	HUMAN|HGNC=6529|UniProtKB=Q13094	Lymphocyte cytosolic protein 2	IGI	9665884	PubMed	PTHR14098:SF1	LYMPHOCYTE CYTOSOLIC PROTEIN 2
P00057	Wnt signaling pathway	P01440	Cadherin	CANLF|Ensembl=ENSCAFG00000000086|UniProtKB=F1PVD5	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF84	CADHERIN-20
P00052	TGF-beta signaling pathway	P01275	P38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	TAS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00012	Cadherin signaling pathway	P00462	Casein kinase II	BOVIN|Ensembl=ENSBTAG00000008837|UniProtKB=P67868	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00051	TCA cycle	P01267	Citrate Synthase	HUMAN|HGNC=2422|UniProtKB=O75390	Citrate synthase, mitochondrial	RCA			PTHR11739:SF8	CITRATE SYNTHASE, MITOCHONDRIAL
P04393	Ras Pathway	P04572	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	IDA	10207617	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P06959	CCKR signaling map	P07224	RHEB-GTP	HUMAN|HGNC=10011|UniProtKB=Q15382	GTP-binding protein Rheb	RCA	19339977	PubMed	PTHR24070:SF264	GTP-BINDING PROTEIN RHEB
P00018	EGF receptor signaling pathway	P00539	14-3-3	RAT|RGD=62002|UniProtKB=P61983	14-3-3 protein gamma	ISS	99360936	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CHICK|Ensembl=ENSGALG00000026748|UniProtKB=F1P493	Uncharacterized protein	IC	89264452	PubMed	PTHR13140:SF728	MYOSIN HEAVY CHAIN, SKELETAL MUSCLE, ADULT
P00034	Integrin signalling pathway	P00925	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00013	Cell cycle	P00480	Proteasome	TRYB2|Gene=Tb11.18.0013|UniProtKB=Q386U6	Proteasome regulatory non-ATP-ase subunit 3	ISS	21975205	PubMed	PTHR10758:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3
P06664	Gonadotropin-releasing hormone receptor pathway	G06676	GnRHR	MOUSE|MGI=MGI=95790|UniProtKB=Q01776	Gonadotropin-releasing hormone receptor	RCA	1333052	PubMed	PTHR24241:SF22	GONADOTROPIN-RELEASING HORMONE RECEPTOR
P00059	p53 pathway	P04612	HDAC1	HUMAN|HGNC=4852|UniProtKB=Q13547	Histone deacetylase 1	IDA	12665570	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P00018	EGF receptor signaling pathway	P00556	PLCgamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	DROME|FlyBase=FBgn0015024|UniProtKB=P54367	Casein kinase I isoform alpha	IDA	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00048	PI3 kinase pathway	P01190	PDK1 ACT	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	15210700	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P02749	Leucine biosynthesis	P03000	Branched chain amino acid aminotransferase	ARATH|TAIR=AT3G19710|UniProtKB=Q9LE06	Methionine aminotransferase BCAT4	ISS			PTHR42825:SF4	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 6-RELATED
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	ARATH|TAIR=AT2G36460|UniProtKB=Q9SJQ9	Fructose-bisphosphate aldolase	TAS	15227981	gi	PTHR11627:SF24	FRUCTOSE-BISPHOSPHATE ALDOLASE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	CAEEL|WormBase=WBGene00004392|UniProtKB=P42170	Ribonucleoside-diphosphate reductase small chain	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00056	VEGF signaling pathway	P01407	Erk	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05915	Opioid proenkephalin pathway	P05994	G-protein	PANTR|Ensembl=ENSPTRG00000006342|UniProtKB=H2Q8A8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00047	PDGF signaling pathway	P01167	Ets	MACMU|Ensembl=ENSMMUG00000008727|UniProtKB=F7E124	GA-binding protein alpha chain	ISS	15298723	PubMed	PTHR11849:SF195	GA-BINDING PROTEIN ALPHA CHAIN
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	CAEBR|Gene=CBG_05938|UniProtKB=H8WGV2	Protein CBR-ITR-1, isoform a	ISS	4262086	gi	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01093	AChE	PANTR|Ensembl=ENSPTRG00000019514|UniProtKB=H2R3Y8	Carboxylic ester hydrolase	ISS	86008285	PubMed	PTHR11559:SF356	ACETYLCHOLINESTERASE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01446	Calcineurin	HUMAN|HGNC=9314|UniProtKB=Q08209	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	IDA	7532676	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00069	COMT	PANTR|Ensembl=ENSPTRG00000014070|UniProtKB=H2QL91	Catechol-O-methyltransferase	ISS	12842307	PubMed	PTHR43836:SF3	CATECHOL O-METHYLTRANSFERASE
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01451	Galpha	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00012	Cadherin signaling pathway	P00470	F-actin	YEAST|SGD=S000001855|UniProtKB=P60010	Actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00805	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IDA	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MOUSE|MGI=MGI=95819|UniProtKB=P35438	Glutamate receptor ionotropic, NMDA 1	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00059	p53 pathway	G04694	p110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01292	RSmads	MONDO|Ensembl=ENSMODG00000003393|UniProtKB=F6S0Q9	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF42	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	CAEEL|WormBase=WBGene00000870|UniProtKB=Q9U2M5	G1/S-specific cyclin-D	IEP	12356903	PubMed	PTHR10177:SF246	CYCLIN D, ISOFORM D
P00056	VEGF signaling pathway	P01405	VRAP	MOUSE|MGI=MGI=1351596|UniProtKB=Q9QXK9	SH2 domain-containing protein 2A	IDA	10692392	PubMed	PTHR14388:SF9	SH2 DOMAIN-CONTAINING PROTEIN 2A
P00053	T cell activation	P01315	Calcineurin	HUMAN|HGNC=9315|UniProtKB=P16298	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	IGI	12091710	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04550	Ral	MACMU|Ensembl=ENSMMUG00000000462|UniProtKB=F6YQU1	Uncharacterized protein	ISS	12856001	PubMed	PTHR24070:SF199	RAS-RELATED PROTEIN RAL-B
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	PANTR|Ensembl=ENSPTRG00000007810|UniProtKB=H2QAM8	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF335	MYOSIN-11
P04372	5-Hydroxytryptamine degredation	P04401	Monoamine Oxidase	DANRE|ZFIN=ZDB-GENE-040329-3|UniProtKB=Q6NSN2	Amine oxidase [flavin-containing]	ISS	8602220	PubMed	PTHR43563:SF2	AMINE OXIDASE  FLAVIN-CONTAINING
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00009	Axon guidance mediated by netrin	P00363	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00556	PLCgamma	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	BOVIN|Ensembl=ENSBTAG00000000219|UniProtKB=F1MCL3	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01457	GBeta	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	RCA	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=19663|UniProtKB=Q9UBI6	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00052	TGF-beta signaling pathway	P01284	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	DANRE|ZFIN=ZDB-GENE-990415-218|UniProtKB=B3DIG4	Frizzled homolog 8c	TAS	8717036	PubMed	PTHR11309:SF126	FRIZZLED-5
P00049	Parkinson disease	P01212	p38 MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DROME|FlyBase=FBgn0000047|UniProtKB=P83967	Actin, indirect flight muscle	ISS	14684598	PubMed	PTHR11937:SF368	ACTIN, INDIRECT FLIGHT MUSCLE
P00012	Cadherin signaling pathway	P00470	F-actin	BOVIN|Ensembl=ENSBTAG00000006189|UniProtKB=P63258	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00034	Integrin signalling pathway	P00925	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	ARATH|TAIR=AT4G11010|UniProtKB=O49203	Nucleoside diphosphate kinase III, chloroplastic/mitochondrial	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P05915	Opioid proenkephalin pathway	P05994	G-protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00036	Interleukin signaling pathway	P00996	STAT	MACMU|Ensembl=ENSMMUG00000010707|UniProtKB=F7G8G5	Signal transducer and activator of transcription	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	TRIAD|EnsemblGenome=TriadG63375|UniProtKB=B3S5E4	Non-muscle actin 6.2	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00778	NMDA receptor	HUMAN|HGNC=4586|UniProtKB=Q13224	Glutamate receptor ionotropic, NMDA 2B	IDA	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04393	Ras Pathway	P04544	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8051109	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	MONDO|Ensembl=ENSMODG00000012050|UniProtKB=F7ALE8	Uncharacterized protein	ISS	1768802	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00029	Huntington disease	P00807	Actin	SCHMA|EnsemblGenome=Smp_183710|UniProtKB=G4VLW1	Putative actin	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00029	Huntington disease	P00797	p53	RAT|RGD=1307083|UniProtKB=D4AA88	Protein Tp73	ISS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00990	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	SCHPO|PomBase=SPAC1687.15|UniProtKB=Q10452	Protein kinase gsk3	IDA	21361340	gi	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	TAS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00057	Wnt signaling pathway	P01444	Wnt	PANTR|Ensembl=ENSPTRG00000004090|UniProtKB=H2Q4F7	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00846	JAK	CANLF|Ensembl=ENSCAFG00000002102|UniProtKB=E2RPW6	Tyrosine-protein kinase	ISS	22482294	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	RCA	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IC	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00056	VEGF signaling pathway	P01407	Erk	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	XENTR|Xenbase=XB-GENE-963560|UniProtKB=Q0VFC4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	IC	10514528	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01067	AChE	DROME|FlyBase=FBgn0000024|UniProtKB=P07140	Acetylcholinesterase	IC			PTHR43918:SF4	ACETYLCHOLINESTERASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	CHICK|Ensembl=ENSGALG00000001476|UniProtKB=F1NSA8	Uncharacterized protein	ISS	1904317	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00029	Huntington disease	P00785	Cytochrome c	ORYSJ|EnsemblGenome=OS01G0935700|UniProtKB=Q942X6	Os01g0935700 protein	IDA	15163634	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P04373	5HT1 type receptor mediated signaling pathway	P04407	K+ channel	PANTR|Ensembl=ENSPTRG00000020614|UniProtKB=H2QWR7	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P06587	Nicotine pharmacodynamics pathway	P06590	GNG	PANTR|Ensembl=ENSPTRG00000006342|UniProtKB=H2Q8A8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04398	p53 pathway feedback loops 2	P04668	p53	DANRE|ZFIN=ZDB-GENE-030814-2|UniProtKB=B0S576	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00005	Angiogenesis	P00182	p38MAPK	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	ISS	20451058	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01451	Galpha	BOVIN|Ensembl=ENSBTAG00000019988|UniProtKB=F1N2V3	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P00047	PDGF signaling pathway	P01167	Ets	CHICK|Ensembl=ENSGALG00000015763|UniProtKB=Q5ZJ46	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF195	GA-BINDING PROTEIN ALPHA CHAIN
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00805	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IDA	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00236	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05730	Endogenous cannabinoid signaling	P05746	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	RCA	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	SCHPO|PomBase=SPBC17D11.07c|UniProtKB=O74762	26S proteasome regulatory subunit rpn2	ISS			PTHR10943:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00056	VEGF signaling pathway	P01423	p38MAPK	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00001	Adrenaline and noradrenaline biosynthesis	P00071	VAT1	PANTR|Ensembl=ENSPTRG00000020039|UniProtKB=H2R9W1	Uncharacterized protein	ISS	92370677	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00047	PDGF signaling pathway	P01143	ERK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00049	Parkinson disease	P01242	Casein kinase I	SCHPO|PomBase=SPBC1347.06c|UniProtKB=P40233	Casein kinase I homolog 1	IDA	10617630	PubMed	PTHR11909:SF155	GILGAMESH, ISOFORM L
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	HUMAN|HGNC=10001|UniProtKB=O15539	Regulator of G-protein signaling 5	IDA	8756726	PubMed	PTHR10845:SF42	REGULATOR OF G-PROTEIN SIGNALING 5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MOUSE|MGI=MGI=96273|UniProtKB=Q64264	5-hydroxytryptamine receptor 1A	IDA			PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	BOVIN|Gene=ADRBK1|UniProtKB=P21146	Beta-adrenergic receptor kinase 1	IDA	8288567	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	DANRE|ZFIN=ZDB-GENE-021119-2|UniProtKB=Q8AWE0	Dopamine D2a receptor	ISS	2039532	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000025240|UniProtKB=F7A7I3	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	BOVIN|Ensembl=ENSBTAG00000009942|UniProtKB=E1BH60	Phosphoinositide phospholipase C	ISS			PTHR10336:SF84	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2
P00029	Huntington disease	P00780	Microtubule	DROME|FlyBase=FBgn0003888|UniProtKB=P08841	Tubulin beta-3 chain	IDA	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00005	Angiogenesis	P00238	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00029	Huntington disease	P00807	Actin	TRIVA|Gene=TVAG_054030|UniProtKB=A2G1K5	Actin	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00010	B cell activation	P00402	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00785	Cytochrome c	CAEBR|Gene=CBG08212|UniProtKB=A8X623	Protein CBR-CYC-1	ISS	9027315	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	IC	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00048	PI3 kinase pathway	P01181	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00019	Endothelin signaling pathway	P00568	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00018	EGF receptor signaling pathway	P00561	STAT	MACMU|Ensembl=ENSMMUG00000000803|UniProtKB=F6R1P6	Signal transducer and activator of transcription	ISS			PTHR11801:SF41	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 2
P00029	Huntington disease	P00788	Calpain	MOUSE|MGI=MGI=88266|UniProtKB=O88456	Calpain small subunit 1	ISS	11675509	PubMed	PTHR44408:SF3	CALPAIN SMALL SUBUNIT 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00556	PLCgamma	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P02776	Serine glycine biosynthesis	P03159	Phosphoserine phosphatase	ANOGA|EnsemblGenome=AGAP012247|UniProtKB=Q7Q038	AGAP012247-PA (Fragment)	ISS			PTHR43344:SF2	PHOSPHOSERINE PHOSPHATASE
P00029	Huntington disease	P00807	Actin	DICDI|dictyBase=DDB_G0275023|UniProtKB=Q553U6	Putative actin-22	IDA	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00023	General transcription regulation	P00660	RNA Polymerase II	PANTR|Ensembl=ENSPTRG00000010183|UniProtKB=H2R6J7	Uncharacterized protein	ISS			PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P00019	Endothelin signaling pathway	P00589	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00036	Interleukin signaling pathway	P00996	STAT	MACMU|Ensembl=ENSMMUG00000010705|UniProtKB=F7G8V4	Signal transducer and activator of transcription	ISS	7514531	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P05916	Opioid prodynorphin pathway	P06002	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01076	CAT	MOUSE|MGI=MGI=88392|UniProtKB=Q03059	Choline O-acetyltransferase	ISS	92155737	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IGI	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	IC	176910	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	IDA	1319556	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00005	Angiogenesis	P00243	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	STRPU|EnsemblGenome=SPU_002788|UniProtKB=W4XHC0	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00049	Parkinson disease	P01219	SAPK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	SCHPO|PomBase=SPCC1442.10c|UniProtKB=P37382	DNA-directed RNA polymerase II subunit RPB3	ISS	2187864	PubMed	PTHR11800:SF2	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00049	Parkinson disease	P01211	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ORYSJ|EnsemblGenome=OS11G0163100|UniProtKB=Q67G20	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04393	Ras Pathway	P04559	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00046	Oxidative stress response	P01135	p38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	TAS	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00005	Angiogenesis	P00244	MAPKAPK2/3	ANOGA|Gene=AgaP_AGAP011890|UniProtKB=Q7PZG1	AGAP011890-PA (Fragment)	ISS			PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P02766	Phenylethylamine degradation	P03103	Phenylethylamine oxidase	ARATH|TAIR=AT4G14940|UniProtKB=O23349	Amine oxidase	ISS			PTHR10638:SF40	AMINE OXIDASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IC	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00021	FGF signaling pathway	P00644	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Ensembl=ENSCAFG00000006119|UniProtKB=E2R428	Serine/threonine-protein kinase	ISS	12676944	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00007	Axon guidance mediated by semaphorins	P00330	CRAM	BOVIN|Ensembl=ENSBTAG00000018576|UniProtKB=A8E641	DPYSL5 protein	ISS	10851247	PubMed	PTHR11647:SF58	DIHYDROPYRIMIDINASE-RELATED PROTEIN 5
P00052	TGF-beta signaling pathway	P01289	I-Smads	CANLF|Ensembl=ENSCAFG00000019069|UniProtKB=F6XXN3	Mothers against decapentaplegic homolog	ISS	9335505	PubMed	PTHR13703:SF27	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 7
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00546	GAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	IGI	11847220	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00019	Endothelin signaling pathway	P00570	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00018	EGF receptor signaling pathway	P00550	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	11384839	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01098	CHT1	BOVIN|Ensembl=ENSBTAG00000004352|UniProtKB=Q2KI26	Solute carrier family 5 (Choline transporter), member 7	RCA			PTHR11819:SF129	HIGH AFFINITY CHOLINE TRANSPORTER 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	DROME|FlyBase=FBgn0266137|UniProtKB=Q24563	Dopamine receptor 2	IDA	11861492	PubMed	PTHR24248:SF56	DOPAMINE RECEPTOR 2
P00049	Parkinson disease	P01211	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00024	Glycolysis	P00679	Aldolase	CANLF|Ensembl=ENSCAFG00000018144|UniProtKB=F1PNI3	Uncharacterized protein	ISS	74094688	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MONDO|Ensembl=ENSMODG00000000771|UniProtKB=F6SSS3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00005	Angiogenesis	P00240	FRS-2	CHICK|Ensembl=ENSGALG00000009966|UniProtKB=E1C021	Uncharacterized protein	ISS	12571252	PubMed	PTHR21258:SF40	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2
P00056	VEGF signaling pathway	P01419	Ets	BOVIN|Ensembl=ENSBTAG00000002341|UniProtKB=A5PJG9	ETS1 protein	ISS	9157999	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00059	p53 pathway	G04692	R2	MOUSE|MGI=MGI=98181|UniProtKB=P11157	Ribonucleoside-diphosphate reductase subunit M2	ISS			PTHR23409:SF20	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00005	Angiogenesis	P00203	Erk	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06959	CCKR signaling map	P07079	p38MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	RCA	12688372	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	PANTR|Ensembl=ENSPTRG00000020661|UniProtKB=H2QWU6	Pyrroline-5-carboxylate reductase	ISS			PTHR11645:SF22	PYRROLINE-5-CARBOXYLATE REDUCTASE 3
P00010	B cell activation	P00371	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00252	Grb2	HUMAN|HGNC=4562|UniProtKB=Q13588	GRB2-related adapter protein	ISS			PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P00021	FGF signaling pathway	P00627	ERK1-2	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00046	Oxidative stress response	P01131	MKP5	BOVIN|Ensembl=ENSBTAG00000009005|UniProtKB=E1BG89	Uncharacterized protein	ISS			PTHR10159:SF30	DUAL SPECIFICITY PROTEIN PHOSPHATASE 15
P05734	Synaptic vesicle trafficking	P05774	NSF	PANTR|Ensembl=ENSPTRG00000009320|UniProtKB=H2QD95	N-ethylmaleimide-sensitive factor	ISS	11348590	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CANLF|Ensembl=ENSCAFG00000013148|UniProtKB=Q5R1P3	Glutamate receptor ionotropic, NMDA 2B	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00021	FGF signaling pathway	P00633	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IGI	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00034	Integrin signalling pathway	P00941	Integrin alpha	PANTR|Ensembl=ENSPTRG00000008576|UniProtKB=H2QBX0	Uncharacterized protein	ISS	3487386	PubMed	PTHR23220:SF79	INTEGRIN ALPHA-E
P00012	Cadherin signaling pathway	P00468	Src	PANTR|Ensembl=ENSPTRG00000013474|UniProtKB=H2QKB4	Tyrosine-protein kinase	ISS	8054685	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	MOUSE|MGI=MGI=99917|UniProtKB=P56564	Excitatory amino acid transporter 1	IC	94365697	PubMed	PTHR11958:SF24	EXCITATORY AMINO ACID TRANSPORTER 1
P00047	PDGF signaling pathway	P01150	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05730	Endogenous cannabinoid signaling	P05751	Galpha	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00775	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	8649368	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	ARATH|TAIR=AT4G11010|UniProtKB=O49203	Nucleoside diphosphate kinase III, chloroplastic/mitochondrial	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00059	p53 pathway	P01484	Chk2	PANTR|Ensembl=ENSPTRG00000014206|UniProtKB=H2QLF1	Uncharacterized protein	ISS	12356735	PubMed	PTHR44167:SF1	SERINE/THREONINE-PROTEIN KINASE CHK2
P00021	FGF signaling pathway	P00638	PLCgamma	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	8787761	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	MOUSE|MGI=MGI=97852|UniProtKB=P62835	Ras-related protein Rap-1A	ISS	8576107	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=7567|UniProtKB=P12882	Myosin-1	IC	10938134	PubMed	PTHR13140:SF484	MYOSIN-1
P00057	Wnt signaling pathway	P01448	CBP	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00034	Integrin signalling pathway	P00951	Jnk	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02732	Coenzyme A linked carnitine metabolism	P02864	L-carnitine dehydratase	BOVIN|Ensembl=ENSBTAG00000032121|UniProtKB=A6QQD0	LOC100125578 protein	ISS			PTHR43949:SF6	SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02752	Mannose metabolism	P03015	GDP-Mannose 4,6-dehydratase	HUMAN|HGNC=4369|UniProtKB=O60547	GDP-mannose 4,6 dehydratase	ISS	9603974	PubMed	PTHR43715:SF1	GDP-MANNOSE 4,6 DEHYDRATASE
P05913	Enkephalin release	P05974	G-Protein (i)	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	15860573	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00012	Cadherin signaling pathway	P00470	F-actin	PANTR|Ensembl=ENSPTRG00000018890|UniProtKB=Q5R1X3	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00012	Cadherin signaling pathway	P00465	TCF/LEF	MONDO|Ensembl=ENSMODG00000020603|UniProtKB=F6ZBJ4	Uncharacterized protein	ISS	11266476	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	CAEEL|WormBase=WBGene00004860|UniProtKB=Q09488	Serine/threonine-protein kinase sma-6	TAS	9395284	PubMed	PTHR23255:SF68	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	DANRE|ZFIN=ZDB-GENE-051202-1|UniProtKB=E7F101	Uncharacterized protein	ISS	14698601	PubMed	PTHR44391:SF2	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	BOVIN|Ensembl=ENSBTAG00000043971|UniProtKB=E1BPT8	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00006	Apoptosis signaling pathway	P00260	AKT	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	22081553	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P02738	De novo purine biosynthesis	P02899	GMP synthase	DEIRA|EnsemblGenome=DR_1874|UniProtKB=Q9RT91	GMP synthase [glutamine-hydrolyzing]	ISS			PTHR11922:SF2	GMP SYNTHASE  GLUTAMINE-HYDROLYZING
P05916	Opioid prodynorphin pathway	P06002	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00059	p53 pathway	P04609	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	XENTR|Xenbase=XB-GENE-487022|UniProtKB=F6SH04	Uncharacterized protein (Fragment)	ISS	8717036	PubMed	PTHR11309:SF34	FRIZZLED-2
P00029	Huntington disease	P00790	beta-Tubulin	SCHMA|EnsemblGenome=Smp_030730|UniProtKB=G4LW34	Tubulin beta chain,putative	ISS	9454836	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P05730	Endogenous cannabinoid signaling	P05748	mGluR	PANTR|Ensembl=ENSPTRG00000018684|UniProtKB=C7G3M7	Glutamate receptor, metabotropic 1	ISS	9407094	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P02743	Formyltetrahydroformate biosynthesis	P02952	Methylene tetrahydrofolate dehydrogenase	DROME|FlyBase=FBgn0020385|UniProtKB=O96553	C-1-tetrahydrofolate synthase, cytoplasmic	ISS			PTHR43274:SF4	C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01070	K+ channel	MACMU|Ensembl=ENSMMUG00000015918|UniProtKB=F7ASA7	Uncharacterized protein	ISS	12223552	PubMed	PTHR11537:SF6	POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 2
P00029	Huntington disease	P00786	ARF	ORNAN|Ensembl=ENSOANG00000013982|UniProtKB=F6URT1	Uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00005	Angiogenesis	P00219	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01084	CHT1	MACMU|Ensembl=ENSMMUG00000010166|UniProtKB=F6QHN1	Uncharacterized protein	RCA			PTHR11819:SF129	HIGH AFFINITY CHOLINE TRANSPORTER 1
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	BACSU|EnsemblGenome=BSU29970|UniProtKB=O34476	Probable cysteine synthase	ISS			PTHR10314:SF102	SUBFAMILY NOT NAMED
P02783	Tryptophan biosynthesis	P03211	Phosphribosyl anthranilate isomerase	THEMA|EnsemblGenome=TM_0139|UniProtKB=Q56320	N-(5'-phosphoribosyl)anthranilate isomerase	ISS			PTHR42894:SF1	N- 5'-PHOSPHORIBOSYL ANTHRANILATE ISOMERASE
P00059	p53 pathway	P04622	Sin3	XENTR|Xenbase=XB-GENE-480875|UniProtKB=F6TAI6	Uncharacterized protein	ISS	10441327	PubMed	PTHR12346:SF2	PAIRED AMPHIPATHIC HELIX PROTEIN SIN3A
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	TAS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00006	Apoptosis signaling pathway	P00322	Cytochrome C	NEUCR|EnsemblGenome=EFNCRG00000001738|UniProtKB=P00048	Cytochrome c	ISS			PTHR11961:SF12	CYTOCHROME C
P00049	Parkinson disease	P01208	Hsp70	ARATH|TAIR=AT5G49910|UniProtKB=Q9LTX9	Heat shock 70 kDa protein 7, chloroplastic	IDA	12150907	PubMed	PTHR19375:SF147	HEAT SHOCK 70 KDA PROTEIN 6, CHLOROPLASTIC-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04397	p53 pathway by glucose deprivation	P04641	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12539654	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P06002	G-protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00045	Notch signaling pathway	P01103	Next	HUMAN|HGNC=7882|UniProtKB=Q04721	Neurogenic locus notch homolog protein 2	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00029	Huntington disease	P00807	Actin	CIOIN|Ensembl=ENSCING00000000848|UniProtKB=F6SCP4	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00035	Interferon-gamma signaling pathway	P00956	SOCS	RAT|RGD=69261|UniProtKB=O70512	Cytokine-inducible SH2-containing protein (Fragment)	ISS	12645661	PubMed	PTHR44649:SF1	CYTOKINE-INDUCIBLE SH2-CONTAINING PROTEIN
P05731	GABA-B receptor II signaling	P05754	Ggamma	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00030	Hypoxia response via HIF activation	P00824	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P02740	De novo pyrimidine ribonucleotides biosythesis	P02927	Dihydrooratate oxidase	THEMA|EnsemblGenome=TM_0333|UniProtKB=Q9WYG8	Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit	ISS			PTHR43517:SF1	DIHYDROOROTATE DEHYDROGENASE  QUINONE , MITOCHONDRIAL
P05913	Enkephalin release	P05974	G-Protein (i)	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00053	T cell activation	P01320	PLC-gamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	BACSU|EnsemblGenome=BSU17380|UniProtKB=P50620	Ribonucleoside-diphosphate reductase subunit alpha	ISS			PTHR11573:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT ALPHA
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00053	T cell activation	P01331	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IDA	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00866	Cytokine receptor	MACMU|Ensembl=ENSMMUG00000003961|UniProtKB=F6Z9E8	Uncharacterized protein	ISS	12163451	PubMed	PTHR20859:SF54	INTERFERON ALPHA/BETA RECEPTOR 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000023202|UniProtKB=F7EU36	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00057	Wnt signaling pathway	P01455	Smad4	MACMU|Ensembl=ENSMMUG00000018334|UniProtKB=F7H894	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	RCA	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01192	p110	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	IC	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04398	p53 pathway feedback loops 2	P04657	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	HUMAN|HGNC=10483|UniProtKB=P21817	Ryanodine receptor 1	ISS	15226293	PubMed	PTHR13715:SF15	RYANODINE RECEPTOR 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00021	FGF signaling pathway	P00638	PLCgamma	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IGI	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00029	Huntington disease	P00811	Arp2/3 complex	BOVIN|Ensembl=ENSBTAG00000015278|UniProtKB=Q5E963	Actin-related protein 2/3 complex subunit 5-like protein	ISS	12473693	PubMed	PTHR12644:SF2	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5-LIKE PROTEIN
P00054	Toll receptor signaling pathway	P01376	Uev1A	MOUSE|MGI=MGI=1913839|UniProtKB=Q9CZY3	Ubiquitin-conjugating enzyme E2 variant 1	ISS			PTHR43915:SF2	UBIQUITIN-CONJUGATING ENZYME E2 VARIANT 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DICDI|dictyBase=DDB_G0283907|UniProtKB=P34099	cAMP-dependent protein kinase catalytic subunit	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00021	FGF signaling pathway	P00641	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00054	Toll receptor signaling pathway	P01369	MKK1	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06739	MEK1/2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	RCA	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04393	Ras Pathway	P04566	Stat 1/3	HUMAN|HGNC=11364|UniProtKB=P40763	Signal transducer and activator of transcription 3	IDA	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00029	Huntington disease	P00777	CBP	PANTR|Ensembl=ENSPTRG00000014418|UniProtKB=H2QLS0	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P02736	Coenzyme A biosynthesis	P02886	Pantetheine-phosphate adenyltransferase	GLOVI|EnsemblGenome=BAC88788|UniProtKB=Q7NMB9	Phosphopantetheine adenylyltransferase	ISS			PTHR21342:SF1	PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	SCHPO|PomBase=SPBC2F12.14c|UniProtKB=O14344	Inosine-5'-monophosphate dehydrogenase	ISS			PTHR11911:SF111	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00034	Integrin signalling pathway	P00927	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12932731	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	HUMAN|HGNC=4587|UniProtKB=Q14957	Glutamate receptor ionotropic, NMDA 2C	IC	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00029	Huntington disease	G01530	HTT	MACMU|Ensembl=ENSMMUG00000008392|UniProtKB=F6VQZ3	Uncharacterized protein	ISS	8268927	PubMed	PTHR10170:SF10	HUNTINGTIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=5286|UniProtKB=P08908	5-hydroxytryptamine receptor 1A	IDA	2156831	PubMed	PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	XENTR|Xenbase=XB-GENE-487200|UniProtKB=Q28GC2	Catenin (Cadherin associated protein), beta 1, 88kDa	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	HUMAN|HGNC=4217|UniProtKB=Q9UK05	Growth/differentiation factor 2	TAS	9759503	PubMed	PTHR11848:SF157	GROWTH/DIFFERENTIATION FACTOR 2
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	CHICK|Ensembl=ENSGALG00000026748|UniProtKB=F1P493	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF728	MYOSIN HEAVY CHAIN, SKELETAL MUSCLE, ADULT
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	MACMU|Ensembl=ENSMMUG00000012005|UniProtKB=F7H091	Metabotropic glutamate receptor 2 isoform a	ISS	20012997	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00018	EGF receptor signaling pathway	P00560	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	RAT|RGD=621320|UniProtKB=P50282	Matrix metalloproteinase-9	TAS	12834808	PubMed	PTHR10201:SF30	MATRIX METALLOPROTEINASE-9
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	PANTR|Ensembl=ENSPTRG00000006510|UniProtKB=H2Q8K1	Presenilin	ISS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	PANTR|Ensembl=ENSPTRG00000017414|UniProtKB=H2QRT0	Uncharacterized protein	ISS	12888804	PubMed	PTHR43940:SF5	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	HUMAN|HGNC=4572|UniProtKB=P42262	Glutamate receptor 2	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	HUMAN|HGNC=6206|UniProtKB=P17535	Transcription factor jun-D	TAS	10664585	PubMed	PTHR11462:SF7	TRANSCRIPTION FACTOR JUN-D
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00010	B cell activation	P00402	Jnk	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00012	Cadherin signaling pathway	P00477	GSK3beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	DANRE|ZFIN=ZDB-GENE-020125-3|UniProtKB=E7F1V8	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P05918	p38 MAPK pathway	P06031	p38alpha	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00036	Interleukin signaling pathway	P00986	eNOS	RAT|RGD=3186|UniProtKB=Q62600	Nitric oxide synthase, endothelial	ISS	9837777	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PHYPA|Gene=PHYPADRAFT_225906|UniProtKB=A9TVP1	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00010	B cell activation	P00402	Jnk	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IDA	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	HUMAN|HGNC=19663|UniProtKB=Q9UBI6	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IDA	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00029	Huntington disease	P00778	NMDA receptor	BOVIN|Ensembl=ENSBTAG00000047202|UniProtKB=G3N3K3	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00053	T cell activation	P01336	Jnk	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00586	Gq	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00048	PI3 kinase pathway	P01199	Galpha	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00006	Apoptosis signaling pathway	P00260	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	MONDO|Ensembl=ENSMODG00000005255|UniProtKB=F7G800	Uncharacterized protein	ISS	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P04384	Gamma-aminobutyric acid synthesis	P04480	GABA aminotransferase	CAEEL|WormBase=WBGene00001794|UniProtKB=Q21217	Probable 4-aminobutyrate aminotransferase, mitochondrial	ISS	8133261	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g210933|UniProtKB=A7SEA7	Predicted protein	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	TAS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00029	Huntington disease	P00790	beta-Tubulin	BOVIN|Gene=TUBB6|UniProtKB=Q2HJ81	Tubulin beta-6 chain	ISS	9454836	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00470	F-actin	MOUSE|MGI=MGI=87902|UniProtKB=P68134	Actin, alpha skeletal muscle	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CAEEL|WormBase=WBGene00000064|UniProtKB=P10984	Actin-2	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00021	FGF signaling pathway	P00628	JNK1-3	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000014498|UniProtKB=F7GEI8	Uncharacterized protein	ISS	11976940	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P04393	Ras Pathway	P04556	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IDA	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02728	Arginine biosynthesis	P02848	N-acetylglutamate synthase	YEAST|SGD=S000000871|UniProtKB=Q01217	Protein ARG5,6, mitochondrial	ISS			PTHR23342:SF0	N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00052	TGF-beta signaling pathway	P01284	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04373	5HT1 type receptor mediated signaling pathway	P04407	K+ channel	CHICK|Ensembl=ENSGALG00000016193|UniProtKB=E1BYI0	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00057	Wnt signaling pathway	P01465	Ggamma	ORNAN|Ensembl=ENSOANG00000000467|UniProtKB=F7F4P1	Uncharacterized protein	ISS	10391901	PubMed	PTHR15936:SF2	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-13
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04570	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00021	FGF signaling pathway	P00640	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IGI	7565716	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00117	E-cadherin C-terminal fragment	MOUSE|MGI=MGI=88356|UniProtKB=P10287	Cadherin-3	IDA	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P00057	Wnt signaling pathway	P01438	PP2A	BOVIN|Ensembl=ENSBTAG00000009245|UniProtKB=Q0P594	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P04633	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02722	Acetate utilization	P02802	Phosphate acetyltransferase	BACTN|EnsemblGenome=BT_2551|UniProtKB=Q8A4P6	Phosphate butyryltransferase	ISS			PTHR43356:SF2	SUBFAMILY NOT NAMED
P02741	Flavin biosynthesis	P02933	Pyrimidine deaminase	GLOVI|Gene=BAC89191|UniProtKB=Q7NL76	Riboflavin biosynthesis protein RibD	ISS			PTHR44288:SF1	RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBD
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00059	p53 pathway	G04694	p110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00010	B cell activation	P00375	Calmodulin	MONBE|Gene=11217|UniProtKB=A9V8J8	Predicted protein	ISS			PTHR23050:SF245	AT16150P-RELATED
P00030	Hypoxia response via HIF activation	P00819	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	HUMAN|HGNC=9281|UniProtKB=P62136	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit	ISS	8392016	PubMed	PTHR11668:SF377	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-ALPHA CATALYTIC SUBUNIT
P00029	Huntington disease	P00761	Truncated Htt	MOUSE|MGI=MGI=96067|UniProtKB=P42859	Huntingtin	TAS	7620118	PubMed	PTHR10170:SF10	HUNTINGTIN
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04393	Ras Pathway	P04573	Elk-1	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	IDA	11279280	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P05731	GABA-B receptor II signaling	P05760	AC	PANTR|Ensembl=ENSPTRG00000007711|UniProtKB=H2QAH4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF319	ADENYLATE CYCLASE TYPE 9
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00754	PDEgamma	XENTR|Xenbase=XB-GENE-945367|UniProtKB=A4IHC2	LOC100124827 protein	ISS			PTHR12122:SF4	RETINAL ROD RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT GAMMA
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IDA	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P02776	Serine glycine biosynthesis	P03157	Phosphoserine aminotransferase	MYCTU|EnsemblGenome=Rv0884c|UniProtKB=P9WQ73	Phosphoserine aminotransferase	ISS			PTHR21152:SF24	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	TAS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00029	Huntington disease	P00775	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PANTR|Ensembl=ENSPTRG00000007810|UniProtKB=H2QAM8	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF335	MYOSIN-11
P05730	Endogenous cannabinoid signaling	P05748	mGluR	CANLF|Ensembl=ENSCAFG00000004381|UniProtKB=J9JH96	Uncharacterized protein	ISS	14614461	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P04393	Ras Pathway	P04542	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	11790551	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00059	p53 pathway	P04609	PI3K	SCHPO|PomBase=SPAC458.05|UniProtKB=P50520	Phosphatidylinositol 3-kinase vps34	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IDA	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00030	Hypoxia response via HIF activation	P00824	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00018	EGF receptor signaling pathway	P00560	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00022	General transcription by RNA polymerase I	P00650	TAF-IB	ARATH|TAIR=AT3G02160|UniProtKB=Q9S7R9	At3g02160	ISS			PTHR12321:SF53	BROMODOMAIN TRANSCRIPTION FACTOR
P00030	Hypoxia response via HIF activation	P00819	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00029	Huntington disease	P00777	CBP	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00053	T cell activation	P01312	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05916	Opioid prodynorphin pathway	P06002	G-protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	RCA	14744463	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00048	PI3 kinase pathway	P01185	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P02731	Biotin biosynthesis	P02857	Biotin synthase	RHOBA|EnsemblGenome=RB10275|UniProtKB=Q7UF84	Biotin synthase	ISS			PTHR22976:SF1	BIOTIN SYNTHASE, MITOCHONDRIAL
P00009	Axon guidance mediated by netrin	P00361	Ena	MOUSE|MGI=MGI=109268|UniProtKB=P70460	Vasodilator-stimulated phosphoprotein	ISS			PTHR11202:SF12	VASODILATOR-STIMULATED PHOSPHOPROTEIN
P00047	PDGF signaling pathway	P01143	ERK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS			PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00048	PI3 kinase pathway	P01189	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00059	p53 pathway	P04630	PP2A	CHICK|Ensembl=ENSGALG00000010273|UniProtKB=P48463	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00786	ARF	MONDO|Ensembl=ENSMODG00000013804|UniProtKB=F6SY88	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF294	ADP-RIBOSYLATION FACTOR 3
P00029	Huntington disease	P00775	Rac	ARATH|TAIR=AT3G51300|UniProtKB=P92978	Rac-like GTP-binding protein ARAC11	ISS			PTHR24072:SF179	RAC-LIKE GTP-BINDING PROTEIN ARAC1-RELATED
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-040718-134|UniProtKB=Q6DH55	Guanine nucleotide binding protein (G protein), beta polypeptide 3, like	ISS	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04395	Vasopressin synthesis	P04597	Signal Peptide	MOUSE|MGI=MGI=97453|UniProtKB=P35454	Oxytocin-neurophysin 1	ISS	9756087	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	DROME|FlyBase=FBgn0000490|UniProtKB=P07713	Protein decapentaplegic	TAS	http://flybase.org/reports/FBgn0000490.html	Website	PTHR11848:SF234	PROTEIN DECAPENTAPLEGIC
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00644	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00162	Pro-BACE-1	MACMU|Ensembl=ENSMMUG00000007785|UniProtKB=F7CQI1	Beta-secretase 1 isoform A preproprotein	ISS	10531052	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00010	B cell activation	P00367	NFAT	MOUSE|MGI=MGI=1920431|UniProtKB=Q8K120	Nuclear factor of activated T-cells, cytoplasmic 4	IDA	12787506	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00036	Interleukin signaling pathway	P00985	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	15210700	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05918	p38 MAPK pathway	P06031	p38alpha	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00008	Axon guidance mediated by Slit/Robo	P00342	Slit	MOUSE|MGI=MGI=1315203|UniProtKB=Q80TR4	Slit homolog 1 protein	IDA	10432110	PubMed	PTHR24373:SF39	SLIT HOMOLOG 1 PROTEIN
P05918	p38 MAPK pathway	P06022	eEF2K	MOUSE|MGI=MGI=1195261|UniProtKB=O08796	Eukaryotic elongation factor 2 kinase	RCA	11500363	PubMed	PTHR14187:SF56	EUKARYOTIC ELONGATION FACTOR 2 KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00021	FGF signaling pathway	P00645	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	PHYPA|Gene=PHYPADRAFT_172686|UniProtKB=A9TYG6	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MACMU|Ensembl=ENSMMUG00000001789|UniProtKB=F7GIU0	5-hydroxytryptamine receptor 1A	ISS	12441358	PubMed	PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P00057	Wnt signaling pathway	P01451	Galpha	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	IDA	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	RAT|RGD=3238|UniProtKB=P01179	Oxytocin-neurophysin 1	ISS	1706187	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00034	Integrin signalling pathway	P00920	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05918	p38 MAPK pathway	P06021	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	10891487	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P02736	Coenzyme A biosynthesis	P02886	Pantetheine-phosphate adenyltransferase	STRCO|EnsemblGenome=CAA22411|UniProtKB=Q9ZBR1	Phosphopantetheine adenylyltransferase	ISS			PTHR21342:SF1	PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE
P00003	Alzheimer disease-amyloid secretase pathway	P00107	kinesin	BOVIN|Ensembl=ENSBTAG00000019334|UniProtKB=Q08DH4	Kinesin light chain 2	ISS	11740561	PubMed	PTHR19959:SF177	KINESIN LIGHT CHAIN 2
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IPI	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00029	Huntington disease	P00790	beta-Tubulin	PHYPA|Gene=PHYPADRAFT_213086|UniProtKB=A9SJR1	Beta-tubulin 4	ISS	9454836	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00302	ATF	BOVIN|Ensembl=ENSBTAG00000009451|UniProtKB=E1BCY2	Uncharacterized protein	ISS			PTHR23351:SF10	JUN DIMERIZATION PROTEIN 2
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00018	EGF receptor signaling pathway	P00562	p38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IGI	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00056	VEGF signaling pathway	P01417	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000011231|UniProtKB=F6WXV4	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00029	Huntington disease	P00771	Sin3A	PANTR|Ensembl=ENSPTRG00000010654|UniProtKB=H2Q9U2	Uncharacterized protein	ISS	10441327	PubMed	PTHR12346:SF1	PAIRED AMPHIPATHIC HELIX PROTEIN SIN3B
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	RAT|RGD=2733|UniProtKB=P42260	Glutamate receptor ionotropic, kainate 2	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00005	Angiogenesis	P00203	Erk	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01242	Casein kinase I	CAEEL|WormBase=WBGene00002202|UniProtKB=P42168	Casein kinase I isoform alpha	ISS	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	ARATH|TAIR=AT4G02195|UniProtKB=Q9SWH4	Syntaxin-42	IC			PTHR19957:SF83	SYNTAXIN-16
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000014828|UniProtKB=F1N1E0	Uncharacterized protein	ISS	11976940	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P04398	p53 pathway feedback loops 2	P04649	Myc	PANTR|Gene=MYC|UniProtKB=P23583	Myc proto-oncogene protein	TAS	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00036	Interleukin signaling pathway	P00990	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00474	Wnt	CAEEL|WormBase=WBGene00000857|UniProtKB=P34888	Protein Wnt-1	ISS	8717036	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00054	Toll receptor signaling pathway	P01369	MKK1	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02746	Heme biosynthesis	P02973	Uroporphyrinogen methyltransferase	AQUAE|EnsemblGenome=aq_207|UniProtKB=O66584	Uroporphyrin-III c-methyltransferase	ISS			PTHR21091:SF16	SIROHEME SYNTHASE
P00005	Angiogenesis	P00243	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CHICK|Ensembl=ENSGALG00000017238|UniProtKB=F1NWG3	Uncharacterized protein	IDA	7476890	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MACMU|Ensembl=ENSMMUG00000001353|UniProtKB=F7D6T8	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00131	HAC1	CHICK|Ensembl=ENSGALG00000009207|UniProtKB=F1NEW3	Uncharacterized protein	ISS			PTHR44028:SF2	TRIPARTITE MOTIF-CONTAINING PROTEIN 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	DROME|FlyBase=FBgn0266452|UniProtKB=Q9VUL1	CTP synthase	ISS			PTHR11550:SF0	CTP SYNTHASE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	HUMAN|HGNC=4588|UniProtKB=O15399	Glutamate receptor ionotropic, NMDA 2D	IC	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00049	Parkinson disease	P01230	Src kinase	PANTR|Ensembl=ENSPTRG00000013371|UniProtKB=H2QK59	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF245	TYROSINE-PROTEIN KINASE HCK
P00021	FGF signaling pathway	P00645	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00057	Wnt signaling pathway	P01450	Bcl9	HUMAN|HGNC=1008|UniProtKB=O00512	B-cell CLL/lymphoma 9 protein	IDA	11955446	PubMed	PTHR15185:SF5	B-CELL CLL/LYMPHOMA 9 PROTEIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	RCA	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	PANTR|Ensembl=ENSPTRG00000000313|UniProtKB=H2PY99	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Gene=HTR1A|UniProtKB=Q9N298	5-hydroxytryptamine receptor 1A	IDA	2156831	PubMed	PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P04393	Ras Pathway	P04556	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00640	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04578	Rho	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	ISS	12169092	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00005	Angiogenesis	P00219	PKC	CAEEL|WormBase=WBGene00012019|UniProtKB=O45818	Serine/threonine-protein kinase dkf-2	ISS			PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P00034	Integrin signalling pathway	P00916	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	MONDO|Ensembl=ENSMODG00000023174|UniProtKB=F7D7P2	Uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF197	CALMODULIN-LIKE PROTEIN 3
P00018	EGF receptor signaling pathway	P00545	JNK1-3	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IGI	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00203	Erk	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05963	MAO	MOUSE|MGI=MGI=96916|UniProtKB=Q8BW75	Amine oxidase [flavin-containing] B	ISS	90344230	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	1482697	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00005	Angiogenesis	P00203	Erk	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00048	PI3 kinase pathway	P01199	Galpha	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IC	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00562	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	ISS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00005	Angiogenesis	P00252	Grb2	DANRE|ZFIN=ZDB-GENE-040426-1975|UniProtKB=Q6PC73	Growth factor receptor-bound protein 2	ISS	4504111	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	MONDO|Ensembl=ENSMODG00000012981|UniProtKB=F7CS91	Uncharacterized protein	ISS	15668138	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00005	Angiogenesis	P00221	JNK1	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	HUMAN|HGNC=9300|UniProtKB=P62714	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	22246731	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P04393	Ras Pathway	P04567	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01443	Phospholipase C	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	BOVIN|Ensembl=ENSBTAG00000011723|UniProtKB=E1BKL6	Uncharacterized protein	ISS	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MACMU|Ensembl=ENSMMUG00000017431|UniProtKB=F7HPP3	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00006	Apoptosis signaling pathway	P00302	ATF	CHICK|Ensembl=ENSGALG00000009287|UniProtKB=O93602	Cyclic AMP-dependent transcription factor ATF-2	ISS	9819389	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00025	Hedgehog signaling pathway	P00682	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00011	Blood coagulation	P00419	FXIIIa	RAT|RGD=621495|UniProtKB=O08619	Coagulation factor XIII A chain	ISS	11067435	gi	PTHR11590:SF42	COAGULATION FACTOR XIII A CHAIN
P02778	Sulfate assimilation	P03164	Adenylylsulfate kinase	BACSU|EnsemblGenome=BSU10910|UniProtKB=O06735	Probable adenylyl-sulfate kinase	ISS			PTHR11055:SF33	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04546	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	IC	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00565	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IGI	2837282	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	HUMAN|HGNC=1950|UniProtKB=P11229	Muscarinic acetylcholine receptor M1	IDA	10069496	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00004	Alzheimer disease-presenilin pathway	P00111	C99	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00047	PDGF signaling pathway	P01159	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00018	EGF receptor signaling pathway	P00552	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00057	Wnt signaling pathway	P01448	CBP	MACMU|Ensembl=ENSMMUG00000000893|UniProtKB=F6T7D0	Histone acetyltransferase p300	ISS	10823891	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00035	Interferon-gamma signaling pathway	P00961	STAT1	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00589	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	RCA	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	TAS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DICDI|dictyBase=DDB_G0268622|UniProtKB=P34145	Rho-related protein rac1B	ISS	21127961	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00029	Huntington disease	P00786	ARF	CHICK|Ensembl=ENSGALG00000005393|UniProtKB=F1NN08	Uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF234	ADP-RIBOSYLATION FACTOR 1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	XENTR|Xenbase=XB-GENE-957248|UniProtKB=Q6GLE6	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00210	eNOS	PANTR|Ensembl=ENSPTRG00000019868|UniProtKB=H2QVM2	Nitric oxide synthase	ISS	93055452	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P02783	Tryptophan biosynthesis	P03206	Anthranilate synthase	ARATH|TAIR=AT1G25220|UniProtKB=Q42565	Anthranilate synthase beta subunit 1, chloroplastic	RCA			PTHR43418:SF6	ANTHRANILATE SYNTHASE BETA SUBUNIT-RELATED
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	RAT|RGD=2027|UniProtKB=P63269	Actin, gamma-enteric smooth muscle	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00045	Notch signaling pathway	P01103	Next	MACMU|Ensembl=ENSMMUG00000018116|UniProtKB=F7FGM9	Delta-like protein	ISS	8955070	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00019	Endothelin signaling pathway	P00572	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	ANOGA|EnsemblGenome=AGAP002308|UniProtKB=Q7QBU0	Pyrroline-5-carboxylate reductase	ISS			PTHR11645:SF0	PYRROLINE-5-CARBOXYLATE REDUCTASE
P00059	p53 pathway	P04630	PP2A	DANRE|ZFIN=ZDB-GENE-040426-2487|UniProtKB=Q803G3	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00219	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	YEAST|SGD=S000001295|UniProtKB=P07278	cAMP-dependent protein kinase regulatory subunit	IC	2372396	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P02770	Pyridoxal phosphate salvage pathway	P03121	Pyridoxal kinase	YEAST|SGD=S000005310|UniProtKB=P53727	Putative pyridoxal kinase BUD17	ISS			PTHR10534:SF12	PYRIDOXAL KINASE BUD17-RELATED
P00029	Huntington disease	P00805	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00466	EGFR	MOUSE|MGI=MGI=104771|UniProtKB=Q61527	Receptor tyrosine-protein kinase erbB-4	ISS	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00012	Cadherin signaling pathway	P00475	Frizzled	MACMU|Ensembl=ENSMMUG00000019399|UniProtKB=F6QFJ6	Frizzled-6	ISS	8717036	PubMed	PTHR11309:SF75	FRIZZLED-6
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	IC	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04395	Vasopressin synthesis	P04597	Signal Peptide	MOUSE|MGI=MGI=97453|UniProtKB=P35454	Oxytocin-neurophysin 1	ISS	6717565	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00045	Notch signaling pathway	P01108	Nicastrin	CANLF|Ensembl=ENSCAFG00000012557|UniProtKB=F1PU73	Uncharacterized protein	ISS	10993067	PubMed	PTHR21092:SF0	NICASTRIN
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2057|UniProtKB=P19328	Alpha-2B adrenergic receptor	IDA	6323229	PubMed	PTHR24248:SF26	ALPHA-2B ADRENERGIC RECEPTOR
P00004	Alzheimer disease-presenilin pathway	P00115	Nicastrin	RAT|RGD=631418|UniProtKB=Q8CGU6	Nicastrin	IDA	16096062	PubMed	PTHR21092:SF0	NICASTRIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00019	Endothelin signaling pathway	P00591	PLCbeta	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	IGI	88311074	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00047	PDGF signaling pathway	P01171	PLCgamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	MACMU|Ensembl=ENSMMUG00000018790|UniProtKB=F6ZPM8	Serine/threonine-protein kinase receptor	ISS	11252892	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P05916	Opioid prodynorphin pathway	P06002	G-protein	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00005	Angiogenesis	P00206	Wnt	RAT|RGD=69346|UniProtKB=G3V7U3	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00747	Rhodopsin	ANOGA|EnsemblGenome=AGAP013149|UniProtKB=F5HMX8	AGAP013149-PA	ISS	1634520	PubMed	PTHR24240:SF85	OPSIN RH1-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ORYSJ|EnsemblGenome=OS11G0163100|UniProtKB=Q67G20	Actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	RAT|RGD=2902|UniProtKB=P22273	Interleukin-6 receptor subunit alpha	IPI	2174054	PubMed	PTHR23036:SF98	INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00010	B cell activation	P00375	Calmodulin	MONDO|Ensembl=ENSMODG00000025146|UniProtKB=F7CLC0	Uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF311	CALMODULIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000002245|UniProtKB=H2RYC6	Uncharacterized protein (Fragment)	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05912	Dopamine receptor mediated signaling pathway	P05966	EPB41	PANTR|Ensembl=ENSPTRG00000013455|UniProtKB=H2QKA1	Uncharacterized protein	ISS	12181426	PubMed	PTHR23280:SF24	BAND 4.1-LIKE PROTEIN 1
P00006	Apoptosis signaling pathway	P00301	Apaf-1	MACMU|Ensembl=ENSMMUG00000022404|UniProtKB=F6U0K7	Apoptotic protease-activating factor 1	ISS	14526190	PubMed	PTHR22845:SF5	APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00034	Integrin signalling pathway	P00923	Arf1	XENTR|Xenbase=XB-GENE-968852|UniProtKB=Q6P7Z6	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF294	ADP-RIBOSYLATION FACTOR 3
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	CANLF|Ensembl=ENSCAFG00000015004|UniProtKB=E2RGD0	Uncharacterized protein	ISS	10500304	PubMed	PTHR44282:SF2	SUPPRESSOR OF CYTOKINE SIGNALING 4
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	TAS	22533439	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	HUMAN|HGNC=407|UniProtKB=P30837	Aldehyde dehydrogenase X, mitochondrial	IC			PTHR11699:SF207	ALDEHYDE DEHYDROGENASE X, MITOCHONDRIAL
P00005	Angiogenesis	P00256	PLC-gamma	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00005	Angiogenesis	P00211	GSK3beta	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02787	Vitamin B6 metabolism	P03244	Pyridoxal kinase	ECOLI|EcoGene=EG12642|UniProtKB=P40191	Pyridoxine/pyridoxal/pyridoxamine kinase	TAS	11206551	PubMed	PTHR10534:SF13	PYRIDOXINE/PYRIDOXAL/PYRIDOXAMINE KINASE
P02785	Valine biosynthesis	P03215	Branched chain amino acid aminotransferase	SYNY3|EnsemblGenome=BAA10792|UniProtKB=P54691	Probable branched-chain-amino-acid aminotransferase	ISS			PTHR42743:SF4	SUBFAMILY NOT NAMED
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	P01428	Frizzled	HUMAN|HGNC=4046|UniProtKB=Q9H461	Frizzled-8	IDA	8717036	PubMed	PTHR11309:SF90	FRIZZLED-8
P00006	Apoptosis signaling pathway	P00260	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01281	SARA	DROME|FlyBase=FBgn0026369|UniProtKB=Q7K9H6	FI05490p	TAS	12040180	PubMed	PTHR22835:SF299	FI05490P
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05939	GRK6	HUMAN|HGNC=4545|UniProtKB=P43250	G protein-coupled receptor kinase 6	RCA	8288567	PubMed	PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P00048	PI3 kinase pathway	P01178	Grb2	CAEEL|WormBase=WBGene00004774|UniProtKB=P29355	Sex muscle abnormal protein 5	TAS	51702266	gi	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	HUMAN|HGNC=9509|UniProtKB=P49810	Presenilin-2	TAS	12846562	PubMed	PTHR10202:SF13	PRESENILIN-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	RAT|RGD=1306821|UniProtKB=F1LNF0	Protein Myh14	ISS	89264452	PubMed	PTHR13140:SF462	MYOSIN-14
P05912	Dopamine receptor mediated signaling pathway	P05960	VAT2	PANTR|Ensembl=ENSPTRG00000002979|UniProtKB=H2Q2M8	Uncharacterized protein	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P02740	De novo pyrimidine ribonucleotides biosythesis	P02927	Dihydrooratate oxidase	MACMU|Ensembl=ENSMMUG00000023312|UniProtKB=F7FAJ8	Dihydroorotate dehydrogenase (quinone), mitochondrial	ISS			PTHR43517:SF1	DIHYDROOROTATE DEHYDROGENASE  QUINONE , MITOCHONDRIAL
P00034	Integrin signalling pathway	P00931	Integrin beta	BOVIN|Ensembl=ENSBTAG00000009987|UniProtKB=F1MTN1	Integrin beta	ISS	5805339	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00057	Wnt signaling pathway	P01446	Calcineurin	ORNAN|Ensembl=ENSOANG00000003197|UniProtKB=F6YVV6	Serine/threonine-protein phosphatase	ISS	12015605	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	IDA	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00052	TGF-beta signaling pathway	P01284	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	BOVIN|Ensembl=ENSBTAG00000018445|UniProtKB=E1BK87	Uncharacterized protein	ISS	11319238	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00018	EGF receptor signaling pathway	P00559	MEK1-2	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IGI	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	IC	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00057	Wnt signaling pathway	P01428	Frizzled	CHICK|Gene=FZD7|UniProtKB=O57329	Frizzled-7	IDA	8717036	PubMed	PTHR11309:SF31	FRIZZLED-7
P00012	Cadherin signaling pathway	P00470	F-actin	BOVIN|Gene=ACTB|UniProtKB=P60712	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	CANLF|Ensembl=ENSCAFG00000023094|UniProtKB=Q076A8	Developmental myosin heavy chain embryonic	ISS	10938134	PubMed	PTHR13140:SF427	MYOSIN-3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00629	PP2A	ARATH|TAIR=AT3G21650|UniProtKB=Q9LVE2	Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' zeta isoform	ISS			PTHR10257:SF27	SERINE/THREONINE PROTEIN PHOSPHATASE 2A 59 KDA REGULATORY SUBUNIT B' GAMMA ISOFORM-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	YEAST|SGD=S000000438|UniProtKB=P38328	Actin-related protein 2/3 complex subunit 1	ISS	12963527	gi	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	LEIMA|EnsemblGenome=LmjF.15.1200|UniProtKB=Q4QF64	Uncharacterized protein	ISS	188830	OMIM	PTHR24361:SF625	SPORULATION-SPECIFIC PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Ensembl=ENSBTAG00000016187|UniProtKB=F1N213	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	BOVIN|Ensembl=ENSBTAG00000019242|UniProtKB=P04758	Acetylcholine receptor subunit beta	IC	22213672	PubMed	PTHR18945:SF477	ACETYLCHOLINE RECEPTOR SUBUNIT BETA
P00005	Angiogenesis	P00194	Paxillin	MOUSE|MGI=MGI=2147677|UniProtKB=Q99N69	Leupaxin	ISS			PTHR24216:SF23	LEUPAXIN
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00054	Toll receptor signaling pathway	P01358	ERK1	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	CAEEL|WormBase=WBGene00001679|UniProtKB=P17343	Guanine nucleotide-binding protein subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00060	Ubiquitin proteasome pathway	P01491	E2	DANRE|ZFIN=ZDB-GENE-040426-1609|UniProtKB=Q7SXH5	Uncharacterized protein	ISS			PTHR24068:SF36	UBIQUITIN-CONJUGATING ENZYME E2 D1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DROME|FlyBase=FBgn0000044|UniProtKB=P53501	Actin-57B	IDA	11889126	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00011	Blood coagulation	P00439	Prekallikrein	MOUSE|MGI=MGI=102849|UniProtKB=P26262	Plasma kallikrein	ISS	6981134	gi	PTHR44459:SF2	PLASMA KALLIKREIN
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	DANRE|ZFIN=ZDB-GENE-010125-1|UniProtKB=B8JHS2	Uncharacterized protein	IDA	12093103	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MOUSE|MGI=MGI=95817|UniProtKB=Q8BMF5	Glutamate receptor ionotropic, kainate 4	ISS	11319238	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	GIAIC|EnsemblGenome=GL50803_7309|UniProtKB=E2RTQ4	Syntaxin-like protein 1	IC			PTHR19957:SF7	SYNTAXIN VAM3
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00034	Integrin signalling pathway	P00922	Collagen	HUMAN|HGNC=2192|UniProtKB=P39059	Collagen alpha-1(XV) chain	IDA	10778855	PubMed	PTHR44929:SF1	COLLAGEN ALPHA-1 XV  CHAIN
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DANRE|ZFIN=ZDB-GENE-070705-74|UniProtKB=B8A569	Uncharacterized protein	IEP	89264452	PubMed	PTHR13140:SF676	MYOSIN, HEAVY POLYPEPTIDE 2, FAST MUSCLE SPECIFIC
P00021	FGF signaling pathway	P00629	PP2A	BOVIN|Ensembl=ENSBTAG00000000469|UniProtKB=P67774	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00054	Toll receptor signaling pathway	P01375	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	TAKRU|Ensembl=ENSTRUG00000008018|UniProtKB=H2T5N4	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	AQUAE|EnsemblGenome=aq_301|UniProtKB=O66648	Glutamine--fructose-6-phosphate aminotransferase [isomerizing]	ISS			PTHR10937:SF0	GH12731P-RELATED
P05730	Endogenous cannabinoid signaling	P05751	Galpha	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	CHICK|Ensembl=ENSGALG00000003880|UniProtKB=Q5ZL19	Syntaxin-6	ISS	10839363	PubMed	PTHR19957:SF104	SYNTAXIN-6
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	RAT|RGD=2248|UniProtKB=P54287	Voltage-dependent L-type calcium channel subunit beta-3	IC			PTHR11824:SF8	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-3
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	RCA	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00054	Toll receptor signaling pathway	P01355	AP1	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-1712|UniProtKB=Q6PBY0	Guanine nucleotide binding protein (G protein), beta 5	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	DROME|FlyBase=FBgn0001123|UniProtKB=P20354	G protein alpha s subunit	ISS	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00219	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05915	Opioid proenkephalin pathway	P05987	peptide F	MACMU|Ensembl=ENSMMUG00000006775|UniProtKB=F7H3N8	Uncharacterized protein	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00021	FGF signaling pathway	P00628	JNK1-3	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS			PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00029	Huntington disease	P00807	Actin	DANRE|ZFIN=ZDB-GENE-000322-1|UniProtKB=Q9I8V1	Actin, alpha 1, skeletal muscle	IDA	14684598	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00019	Endothelin signaling pathway	P00584	Gs	CHICK|Ensembl=ENSGALG00000007509|UniProtKB=F1NM72	Uncharacterized protein	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P04393	Ras Pathway	P04578	Rho	RAT|RGD=1304965|UniProtKB=A0A0G2K6E0	Protein Rhoc	ISS	12090470	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00036	Interleukin signaling pathway	P00965	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00243	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00005	Angiogenesis	P00225	MEK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS			PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IGI	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00059	p53 pathway	P04633	P110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	CAEBR|Gene=CBG20938|UniProtKB=A8XZ02	Protein CBR-RAS-1	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P04397	p53 pathway by glucose deprivation	G04706	TSC2	MACMU|Ensembl=ENSMMUG00000002808|UniProtKB=F7H034	Uncharacterized protein	ISS	12150915	PubMed	PTHR10063:SF0	TUBERIN
P00005	Angiogenesis	P00245	Rac	RAT|RGD=1303143|UniProtKB=Q6AYD8	Protein Arhgap8	ISS			PTHR23176:SF3	PROTEIN PRR5-ARHGAP8-RELATED
P00029	Huntington disease	P00807	Actin	MOUSE|MGI=MGI=104589|UniProtKB=P63268	Actin, gamma-enteric smooth muscle	IDA	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P04393	Ras Pathway	P04559	Rac	MONDO|Ensembl=ENSMODG00000003244|UniProtKB=F6THF0	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00014	Cholesterol biosynthesis	P00497	Anosterol synthase	MOUSE|MGI=MGI=1336155|UniProtKB=Q8BLN5	Lanosterol synthase	ISS	P38604	SPACC	PTHR11764:SF20	LANOSTEROL SYNTHASE
P00029	Huntington disease	P00788	Calpain	MACMU|Ensembl=ENSMMUG00000006431|UniProtKB=F7HSF8	Uncharacterized protein	ISS	11675509	PubMed	PTHR10183:SF280	CALPAIN-12
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	PANTR|Ensembl=ENSPTRG00000034469|UniProtKB=H2Q2V0	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00056	VEGF signaling pathway	P01403	VEGFR-2	CHICK|Ensembl=ENSGALG00000013907|UniProtKB=F1NW21	Uncharacterized protein	ISS			PTHR24416:SF45	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06724	Glut1	MOUSE|MGI=MGI=95755|UniProtKB=P17809	Solute carrier family 2, facilitated glucose transporter member 1	RCA			PTHR23503:SF51	SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 1
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	MOUSE|MGI=MGI=88396|UniProtKB=P12657	Muscarinic acetylcholine receptor M1	ISS	12181435	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00019	Endothelin signaling pathway	P00575	furin	CANLF|Ensembl=ENSCAFG00000012353|UniProtKB=E2RSE6	Uncharacterized protein	ISS	11861638	PubMed	PTHR42884:SF1	FURIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	PANTR|Ensembl=ENSPTRG00000020589|UniProtKB=H2QWQ6	Uncharacterized protein	ISS	12890691	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	9754712	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00048	PI3 kinase pathway	P01176	JAK	CANLF|Ensembl=ENSCAFG00000002102|UniProtKB=E2RPW6	Tyrosine-protein kinase	ISS	22482294	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00274	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00034	Integrin signalling pathway	P00936	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IPI	10799299	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04665	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04651	Ras	CHICK|Ensembl=ENSGALG00000014033|UniProtKB=E1BTS2	Uncharacterized protein	ISS	3023884	PubMed	PTHR24070:SF186	GTPASE KRAS
P00007	Axon guidance mediated by semaphorins	P00336	Cdk5	HUMAN|HGNC=1774|UniProtKB=Q00535	Cyclin-dependent-like kinase 5	ISS			PTHR24056:SF46	CYCLIN-DEPENDENT-LIKE KINASE 5
P00034	Integrin signalling pathway	P00920	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00050	Plasminogen activating cascade	P01250	MMP-13	PANTR|Ensembl=ENSPTRG00000004222|UniProtKB=H2Q4N4	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF165	COLLAGENASE 3
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	PANTR|Ensembl=ENSPTRG00000015241|UniProtKB=Q5IS72	D(3) dopamine receptor	ISS	11861492	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00471	Cadherin	BOVIN|Ensembl=ENSBTAG00000021846|UniProtKB=F1MHH5	Uncharacterized protein	ISS	8120095	PubMed	PTHR24026:SF38	CADHERIN EGF LAG SEVEN-PASS G-TYPE RECEPTOR 3
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IGI	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00009	Axon guidance mediated by netrin	P00363	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=109355|UniProtKB=O35526	Syntaxin-1A	ISS	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	HUMAN|HGNC=5294|UniProtKB=P41595	5-hydroxytryptamine receptor 2B	ISS	8143856	PubMed	PTHR24247:SF31	5-HYDROXYTRYPTAMINE RECEPTOR 2B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00009	Axon guidance mediated by netrin	P00364	cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00059	p53 pathway	P04630	PP2A	XENTR|Xenbase=XB-GENE-484003|UniProtKB=Q6P365	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	YEAST|SGD=S000003272|UniProtKB=P14681	Mitogen-activated protein kinase KSS1	IDA			PTHR24055:SF338	MITOGEN-ACTIVATED PROTEIN KINASE KSS1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	METJA|EnsemblGenome=MJ_1265|UniProtKB=Q58661	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00021	FGF signaling pathway	P00648	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00021	FGF signaling pathway	P00643	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00912	Arp2/3	MOUSE|MGI=MGI=1343142|UniProtKB=Q9WV32	Actin-related protein 2/3 complex subunit 1B	IPI	12932731	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	MONDO|Ensembl=ENSMODG00000000981|UniProtKB=F7ES59	Uncharacterized protein	ISS	14871999	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	TAS	9298898	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00054	Toll receptor signaling pathway	P01358	ERK1	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05913	Enkephalin release	P05972	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00020	FAS signaling pathway	P00615	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00819	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00780	Microtubule	RAT|RGD=628595|UniProtKB=Q4QRB4	Tubulin beta-3 chain	IDA	12932731	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	11847220	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	TAKRU|Ensembl=ENSTRUG00000016241|UniProtKB=H2UX35	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF305	PROTEIN KINASE C
P00059	p53 pathway	P04609	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01433	SIAH-1	ARATH|TAIR=AT5G53360|UniProtKB=Q8S3N1	E3 ubiquitin-protein ligase SINAT5	IDA	11389839	PubMed	PTHR10315:SF34	E3 UBIQUITIN-PROTEIN LIGASE SINAT3-RELATED
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	ARATH|TAIR=AT4G23900|UniProtKB=Q8LAH8	Nucleoside diphosphate kinase IV, chloroplastic/mitochondrial	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	XENTR|Xenbase=XB-GENE-1005779|UniProtKB=F7E3I6	Uncharacterized protein	ISS	11861492	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P02770	Pyridoxal phosphate salvage pathway	P03122	Pyridoxamine kinase	SCHPO|PomBase=SPCC18.10|UniProtKB=O74860	Putative pyridoxal kinase C18.10	ISS	11859360	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01143	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00916	Ras	PANTR|Ensembl=ENSPTRG00000011307|UniProtKB=H2QGV8	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF245	RAS-RELATED PROTEIN R-RAS
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IDA	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Gene=CHRM5|UniProtKB=Q5IS53	Muscarinic acetylcholine receptor M5	ISS			PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00019	Endothelin signaling pathway	P00570	PKA	LEIMA|EnsemblGenome=LmjF.35.3960|UniProtKB=E9AFM1	Protein kinase A catalytic subunit isoform 2	ISS	10218114	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01206	14-3-3	ORNAN|Ensembl=ENSOANG00000007305|UniProtKB=F6XW91	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00007	Axon guidance mediated by semaphorins	P00336	Cdk5	MACMU|Ensembl=ENSMMUG00000020451|UniProtKB=F6VZU3	Uncharacterized protein	ISS	12372285	PubMed	PTHR24056:SF46	CYCLIN-DEPENDENT-LIKE KINASE 5
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IGI	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00065	DAT	MOUSE|MGI=MGI=94862|UniProtKB=Q61327	Sodium-dependent dopamine transporter	ISS	92107910	PubMed	PTHR11616:SF38	SODIUM-DEPENDENT DOPAMINE TRANSPORTER
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=109356|UniProtKB=O09044	Synaptosomal-associated protein 23	IC	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CAEEL|WormBase=WBGene00001679|UniProtKB=P17343	Guanine nucleotide-binding protein subunit beta-1	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00048	PI3 kinase pathway	P01199	Galpha	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	IC	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00008	Axon guidance mediated by Slit/Robo	P00344	Netrin	MACMU|Ensembl=ENSMMUG00000006923|UniProtKB=F7EUX0	Uncharacterized protein	ISS			PTHR10574:SF27	NETRIN-G2
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	CHICK|Gene=PSEN2|UniProtKB=Q90X07	Presenilin-2	IDA	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00006	Apoptosis signaling pathway	P00269	MAPK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	IDA	8920915	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P05918	p38 MAPK pathway	P06023	MEF	DROME|FlyBase=FBgn0011656|UniProtKB=P40791	Myocyte-specific enhancer factor 2	RCA			PTHR11945:SF277	MYOCYTE-SPECIFIC ENHANCER FACTOR 2
P00034	Integrin signalling pathway	P00931	Integrin beta	MOUSE|MGI=MGI=96611|UniProtKB=P11835	Integrin beta-2	IDA	10330002	PubMed	PTHR10082:SF15	INTEGRIN BETA-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	PANTR|Ensembl=ENSPTRG00000007489|UniProtKB=H2QA49	Tyrosine-protein kinase receptor	ISS	249616	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00021	FGF signaling pathway	P00629	PP2A	MOUSE|MGI=MGI=1321159|UniProtKB=P63330	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00009	Axon guidance mediated by netrin	P00363	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00807	Actin	XENTR|Xenbase=XB-GENE-490883|UniProtKB=Q6NVA9	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00641	SOS	DICDI|dictyBase=DDB_G0276019|UniProtKB=Q552M5	Ras guanine nucleotide exchange factor Y	ISS			PTHR23113:SF99	PROTEIN SON OF SEVENLESS
P00048	PI3 kinase pathway	P01177	P110ACT	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00007	Axon guidance mediated by semaphorins	P00334	PlexinA1	MACMU|Ensembl=ENSMMUG00000016720|UniProtKB=F6VDJ2	Uncharacterized protein	ISS	10520995	PubMed	PTHR22625:SF35	PLEXIN-A1
P00005	Angiogenesis	P00206	Wnt	DANRE|ZFIN=ZDB-GENE-980526-416|UniProtKB=Q92048	Protein Wnt-2	ISS	11266476	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IPI	12707323	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	MACMU|Ensembl=ENSMMUG00000011906|UniProtKB=F7HMX1	26S proteasome non-ATPase regulatory subunit 14	ISS	9727008	PubMed	PTHR10410:SF5	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 14
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	ANOGA|EnsemblGenome=AGAP001394|UniProtKB=F5HMS4	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00005	Angiogenesis	P00221	JNK1	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05916	Opioid prodynorphin pathway	P06002	G-protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P06209	ALP23B signaling pathway	P06220	BABO	DROME|FlyBase=FBgn0011300|UniProtKB=A1Z7L8	Receptor protein serine/threonine kinase	IEA	10683140	PubMed	PTHR23255:SF71	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	RCA			PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00054	Toll receptor signaling pathway	P01375	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	RAT|RGD=3564|UniProtKB=O08774	Regulator of G-protein signaling 12	IDA	8756726	PubMed	PTHR10845:SF149	REGULATOR OF G-PROTEIN SIGNALING 12
P00047	PDGF signaling pathway	P01157	MAPKAPK2	CHICK|Ensembl=ENSGALG00000000883|UniProtKB=F1NCY7	Uncharacterized protein	ISS			PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00020	FAS signaling pathway	P00614	ASK1	MACMU|Ensembl=ENSMMUG00000016376|UniProtKB=F7G2W1	Uncharacterized protein	TAS			PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00584	Gs	MACMU|Ensembl=ENSMMUG00000010266|UniProtKB=F6PV18	Uncharacterized protein	RCA			PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00018	EGF receptor signaling pathway	P00556	PLCgamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00054	Toll receptor signaling pathway	P01369	MKK1	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00060	Ubiquitin proteasome pathway	P01491	E2	PANTR|Ensembl=ENSPTRG00000012699|UniProtKB=H2QJ28	Uncharacterized protein	ISS			PTHR24068:SF63	UBIQUITIN-CONJUGATING ENZYME E2 E3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CAEEL|WormBase=WBGene00000064|UniProtKB=P10984	Actin-2	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	IXOSC|EnsemblGenome=ISCW009711|UniProtKB=B7Q3T6	THO complex subunit, putative	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00036	Interleukin signaling pathway	P00965	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	IC	12471242	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00543	ERK1-2	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	IDA	12885769	PubMed	PTHR10202:SF13	PRESENILIN-2
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	YEAST|SGD=S000005738|UniProtKB=P18851	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00036	Interleukin signaling pathway	P00990	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00211	GSK3beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	DANRE|ZFIN=ZDB-GENE-051202-2|UniProtKB=Q6ZM67	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF3	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	8838325	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00029	Huntington disease	P00790	beta-Tubulin	TRIVA|Gene=TVAG_034440|UniProtKB=A2EM81	Beta-tubulin, putative	TAS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00059	p53 pathway	G04694	p110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05734	Synaptic vesicle trafficking	P05774	NSF	RAT|RGD=621594|UniProtKB=Q9QUL6	Vesicle-fusing ATPase	ISS	11348590	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	SCHMA|EnsemblGenome=Smp_161920|UniProtKB=G4VSW5	Putative actin	IC	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BOVIN|Gene=ACTG2|UniProtKB=Q5E9B5	Actin, gamma-enteric smooth muscle	ISS	3487386	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00045	Notch signaling pathway	P01103	Next	CANLF|Ensembl=ENSCAFG00000005627|UniProtKB=E2QUR0	Delta-like protein	ISS	7697721	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CANLF|Ensembl=ENSCAFG00000023094|UniProtKB=Q076A8	Developmental myosin heavy chain embryonic	ISS	10938134	PubMed	PTHR13140:SF427	MYOSIN-3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00015	Circadian clock system	G01497	cry	CANLF|Ensembl=ENSCAFG00000001797|UniProtKB=E2RMX4	Uncharacterized protein	ISS	10217146	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00029	Huntington disease	P00801	Fos protein	TAKRU|Ensembl=ENSTRUG00000010431|UniProtKB=H2TNK9	Uncharacterized protein	ISS			PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	RAT|RGD=1306821|UniProtKB=F1LNF0	Protein Myh14	ISS	89264452	PubMed	PTHR13140:SF462	MYOSIN-14
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00301	Apaf-1	BOVIN|Ensembl=ENSBTAG00000021661|UniProtKB=F1MUW4	Apoptotic protease-activating factor 1	ISS	9267021	PubMed	PTHR22845:SF5	APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
P00005	Angiogenesis	P00193	SOS-1	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00017	DNA replication	P00538	RNase H	YEAST|SGD=S000004847|UniProtKB=Q04740	Ribonuclease H	ISS	97313268	PubMed	PTHR10642:SF0	RIBONUCLEASE H1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00547	PP2A	XENTR|Xenbase=XB-GENE-943352|UniProtKB=F6TPY3	Uncharacterized protein (Fragment)	ISS			PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	IDA	12039949	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00019	Endothelin signaling pathway	P00572	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00008	Axon guidance mediated by Slit/Robo	P00347	Abl	MOUSE|MGI=MGI=87859|UniProtKB=P00520	Tyrosine-protein kinase ABL1	ISS	8986783	PubMed	PTHR24418:SF88	TYROSINE-PROTEIN KINASE ABL1
P00048	PI3 kinase pathway	P01179	PKB	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00633	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00023	General transcription regulation	P00660	RNA Polymerase II	ORNAN|Ensembl=ENSOANG00000014684|UniProtKB=F7CX67	Uncharacterized protein	ISS	415387	gi	PTHR10773:SF12	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	8170357	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00223	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02761	Pantothenate biosynthesis	P03067	3-methyl-2-oxobutanoate hydroxymethyltransferase	BACTN|EnsemblGenome=BT_0698|UniProtKB=Q8A9W7	3-methyl-2-oxobutanoate hydroxymethyltransferase	ISS			PTHR20881:SF0	3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MACMU|Gene=CHRM1|UniProtKB=P56489	Muscarinic acetylcholine receptor M1	IDA	12915051	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05915	Opioid proenkephalin pathway	P05993	AC	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DROME|FlyBase=FBgn0004623|UniProtKB=P29829	Guanine nucleotide-binding protein subunit beta-2	IC	9754712	PubMed	PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	TAKRU|Ensembl=ENSTRUG00000007253|UniProtKB=H2SZQ1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	TAKRU|Ensembl=ENSTRUG00000005446|UniProtKB=H2SKZ5	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00046	Oxidative stress response	P01135	p38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00015	Circadian clock system	G01500	bmal1	HUMAN|HGNC=701|UniProtKB=O00327	Aryl hydrocarbon receptor nuclear translocator-like protein 1	IDA	11163178	PubMed	PTHR23042:SF52	ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 1
P04393	Ras Pathway	P04557	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00019	Endothelin signaling pathway	P00589	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00182	p38MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02772	Pyruvate metabolism	P03135	Phosphoenolpyruvate Carboxykinase	SULSO|EnsemblGenome=SSO2537|UniProtKB=Q97VS5	Phosphoenolpyruvate carboxykinase [GTP]	ISS	11427726	PubMed	PTHR11561:SF0	PHOSPHOENOLPYRUVATE CARBOXYKINASE  GTP -RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00012	Cadherin signaling pathway	P00465	TCF/LEF	CANLF|Ensembl=ENSCAFG00000011252|UniProtKB=F1Q334	Uncharacterized protein	ISS	9039917	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00805	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06814	Annexin A5	MOUSE|MGI=MGI=106008|UniProtKB=P48036	Annexin A5	RCA			PTHR10502:SF26	ANNEXIN A5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	DANRE|ZFIN=ZDB-GENE-990415-199|UniProtKB=A3QJX7	Uncharacterized protein	IDA	11259487	PubMed	PTHR24229:SF74	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	HUMAN|HGNC=1953|UniProtKB=P08173	Muscarinic acetylcholine receptor M4	IDA			PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	PANTR|Ensembl=ENSPTRG00000010931|UniProtKB=H2R650	Uncharacterized protein	ISS	15858232	PubMed	PTHR13715:SF15	RYANODINE RECEPTOR 1
P00034	Integrin signalling pathway	P00936	PI3K	DROME|FlyBase=FBgn0015278|UniProtKB=Q7K3H0	LD28067p	IPI	7937853	PubMed	PTHR10048:SF64	LD28067P
P00047	PDGF signaling pathway	P01171	PLCgamma	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00375	Calmodulin	BRAFL|Gene=BRAFLDRAFT_124869|UniProtKB=C3ZEW0	Putative uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF263	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00912	Arp2/3	HUMAN|HGNC=705|UniProtKB=O15144	Actin-related protein 2/3 complex subunit 2	IPI	17943202	gi	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00005	Angiogenesis	P00195	APC	MACMU|Ensembl=ENSMMUG00000003053|UniProtKB=F6VET0	Uncharacterized protein	ISS	10491393	PubMed	PTHR12607:SF3	ADENOMATOUS POLYPOSIS COLI PROTEIN 2
P00057	Wnt signaling pathway	P01435	SWI/SNF	BOVIN|Ensembl=ENSBTAG00000019704|UniProtKB=F1MLM2	Uncharacterized protein	ISS	11532957	PubMed	PTHR10799:SF870	HELICASE-LIKE TRANSCRIPTION FACTOR
P00056	VEGF signaling pathway	P01406	VEGF	MOUSE|MGI=MGI=103178|UniProtKB=Q00731	Vascular endothelial growth factor A	ISS			PTHR12025:SF5	VASCULAR ENDOTHELIAL GROWTH FACTOR A
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=12785|UniProtKB=Q9Y6F9	Protein Wnt-6	IDA	11266476	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P00029	Huntington disease	P00786	ARF	DROME|FlyBase=FBgn0000115|UniProtKB=P25160	ADP-ribosylation factor-like protein 1	IPI	12932731	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	RAT|RGD=2641|UniProtKB=Q62844	Tyrosine-protein kinase Fyn	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CAEEL|WormBase=WBGene00006536|UniProtKB=O17921	TuBulin, Beta	ISS	9454836	PubMed	PTHR11588:SF157	TUBULIN, BETA
P00021	FGF signaling pathway	P00629	PP2A	MONDO|Ensembl=ENSMODG00000019007|UniProtKB=F7C5Z9	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00066	DOPA decarb.	DANRE|ZFIN=ZDB-GENE-040426-2656|UniProtKB=Q7SZR0	Ddc protein	ISS	90339966	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P02763	Peptidoglycan biosynthesis	P03086	N-acetylglucosamine-1-phosphate uridyltransferase	BACSU|EnsemblGenome=BSU00500|UniProtKB=P14192	Bifunctional protein GlmU	ISS			PTHR43584:SF3	BIFUNCTIONAL PROTEIN GLMU
P00030	Hypoxia response via HIF activation	P00823	PI3K	CAEEL|WormBase=WBGene00006932|UniProtKB=Q9TXI7	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	BOVIN|Ensembl=ENSBTAG00000009245|UniProtKB=Q0P594	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00221	JNK1	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	BOVIN|Ensembl=ENSBTAG00000046248|UniProtKB=Q58CQ2	Actin-related protein 2/3 complex subunit 1B	ISS	12963527	gi	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00048	PI3 kinase pathway	P01202	p85	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	BOVIN|Ensembl=ENSBTAG00000016662|UniProtKB=F1ML89	Uncharacterized protein	ISS			PTHR11405:SF38	CARBAMOYL-PHOSPHATE SYNTHASE  AMMONIA , MITOCHONDRIAL
P00053	T cell activation	P01312	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	ARATH|TAIR=AT4G23900|UniProtKB=Q8LAH8	Nucleoside diphosphate kinase IV, chloroplastic/mitochondrial	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04393	Ras Pathway	P04565	MKK4/7	PANTR|Ensembl=ENSPTRG00000008783|UniProtKB=H2QCA7	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00009	Axon guidance mediated by netrin	P00360	DCC/UNC-40	PANTR|Ensembl=ENSPTRG00000010031|UniProtKB=H2QEJ8	Uncharacterized protein	ISS	12798294	PubMed	PTHR44146:SF3	NETRIN RECEPTOR DCC
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	PANTR|Ensembl=ENSPTRG00000007084|UniProtKB=H2Q9G5	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04395	Vasopressin synthesis	P04589	Signal Peptidase	NEUCR|EnsemblGenome=EFNCRG00000006621|UniProtKB=Q7S7J6	Microsomal signal peptidase subunit	IC	2092035	PubMed	PTHR12804:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 3
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	MOUSE|MGI=MGI=1336171|UniProtKB=Q9DAS9	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IDA			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00018	EGF receptor signaling pathway	P00565	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00049	Parkinson disease	P01211	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	20331588	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00056	VEGF signaling pathway	P01407	Erk	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00754	PDEgamma	BOVIN|Ensembl=ENSBTAG00000000354|UniProtKB=P04972	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	TAS	3011376	PubMed	PTHR12122:SF4	RETINAL ROD RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT GAMMA
P00047	PDGF signaling pathway	P01161	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00047	PDGF signaling pathway	P01154	Ras	CAEBR|Gene=CBG20938|UniProtKB=A8XZ02	Protein CBR-RAS-1	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00059	p53 pathway	P01486	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00371	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00981	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00049	Parkinson disease	P01227	20S proteasome	CAEBR|Gene=CBG04619|UniProtKB=A8WY28	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF11	PROTEASOME SUBUNIT ALPHA TYPE-6
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04398	p53 pathway feedback loops 2	P04658	PTEN	MOUSE|MGI=MGI=2446460|UniProtKB=G5E8H5	MCG118205, isoform CRA_c	IGI			PTHR12305:SF32	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE TPTE2-RELATED
P00029	Huntington disease	P00790	beta-Tubulin	MOUSE|MGI=MGI=107861|UniProtKB=Q7TMM9	Tubulin beta-2A chain	ISS	12932731	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00005	Angiogenesis	P00219	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00048	PI3 kinase pathway	P01182	Ras	XENTR|Xenbase=XB-GENE-494548|UniProtKB=F7EC26	Uncharacterized protein	ISS	20362513	PubMed	PTHR24070:SF186	GTPASE KRAS
P04398	p53 pathway feedback loops 2	P04651	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IDA	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00059	p53 pathway	P01480	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	YEAST|SGD=S000003214|UniProtKB=P46655	Glutamate--tRNA ligase, cytoplasmic	ISS			PTHR43097:SF5	GLUTAMATE--TRNA LIGASE, CYTOPLASMIC
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00016	Cytoskeletal regulation by Rho GTPase	P00507	Rho	CAEBR|Gene=CBG13664|UniProtKB=A8XIF5	Protein CBR-RHO-1	ISS	7798239	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IDA	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00010	B cell activation	P00371	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00927	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12676940	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00056	VEGF signaling pathway	P01407	Erk	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00047	PDGF signaling pathway	P01154	Ras	PANTR|Ensembl=ENSPTRG00000034469|UniProtKB=H2Q2V0	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00182	p38MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00059	p53 pathway	P01486	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	BOVIN|Ensembl=ENSBTAG00000002215|UniProtKB=Q08DQ2	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2	ISS			PTHR10937:SF10	GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE  ISOMERIZING  2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DANRE|ZFIN=ZDB-GENE-040625-35|UniProtKB=Q6IQL9	Novel actin protein	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	TAS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04398	p53 pathway feedback loops 2	P04651	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00049	Parkinson disease	P01242	Casein kinase I	PANTR|Ensembl=ENSPTRG00000014365|UniProtKB=H2R0C8	Casein kinase 1, epsilon	ISS	11865049	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00010	B cell activation	P00391	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01173	STAT	MACMU|Ensembl=ENSMMUG00000010705|UniProtKB=F7G8V4	Signal transducer and activator of transcription	ISS	8732682	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00020	FAS signaling pathway	P00616	Nuclear Lamin	CHICK|Gene=LMNB1|UniProtKB=P14731	Lamin-B1	TAS	11165516	PubMed	PTHR23239:SF157	LAMIN-B1
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00057	Wnt signaling pathway	P01428	Frizzled	MONDO|Ensembl=ENSMODG00000008701|UniProtKB=F6PWM3	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF22	FRIZZLED-3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	MACMU|Ensembl=ENSMMUG00000015658|UniProtKB=F7AJI7	Uncharacterized protein	ISS	6382022	PubMed	PTHR15071:SF17	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
P00006	Apoptosis signaling pathway	P00303	c-Jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	3136397	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00019	Endothelin signaling pathway	P00570	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00005	Angiogenesis	P00219	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000022319|UniProtKB=F6XDA0	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	CANLF|Ensembl=ENSCAFG00000005685|UniProtKB=E2R481	Uncharacterized protein	ISS			PTHR24361:SF183	SERINE/THREONINE-PROTEIN KINASE PAK 7
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00021	FGF signaling pathway	P00643	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CAEBR|Gene=CBG20196|UniProtKB=A8XX81	Protein CBR-TBB-2	ISS	9454836	PubMed	PTHR11588:SF84	TUBULIN BETA-2 CHAIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00057	Wnt signaling pathway	P01438	PP2A	MOUSE|MGI=MGI=2388479|UniProtKB=Q6PD03	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform	ISS	12110603	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	RAT|RGD=2746|UniProtKB=P31424	Metabotropic glutamate receptor 5	ISS	92317054	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P04398	p53 pathway feedback loops 2	P04658	PTEN	TAKRU|Ensembl=ENSTRUG00000009851|UniProtKB=H2TJ90	Uncharacterized protein	IGI	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00034	Integrin signalling pathway	P00922	Collagen	XENTR|Xenbase=XB-GENE-6258353|UniProtKB=Q6P4Z2	Collagen alpha-1(II) chain	ISS	10778855	PubMed	PTHR24023:SF58	COLLAGEN ALPHA-1 II  CHAIN
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00021	FGF signaling pathway	P00625	MKK3,6	HUMAN|HGNC=6843|UniProtKB=P46734	Dual specificity mitogen-activated protein kinase kinase 3	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00049	Parkinson disease	P01212	p38 MAPK	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	NAS	10995439	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00642	MEK1-2	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	TAS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00562	p38	CAEBR|Gene=CBG01555|UniProtKB=A8WRD7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00705	Gsalpha	CHICK|Ensembl=ENSGALG00000007509|UniProtKB=F1NM72	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	ISS	11554549	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P06587	Nicotine pharmacodynamics pathway	P06602	PPP1CA	DAPPU|EnsemblGenome=DAPPUDRAFT_231787|UniProtKB=E9HKA6	Serine/threonine-protein phosphatase	ISS	8392016	PubMed	PTHR11668:SF402	SERINE/THREONINE-PROTEIN PHOSPHATASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	LEIMA|EnsemblGenome=LmjF.18.1080|UniProtKB=Q27687	Protein kinase A catalytic subunit	IC	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	CANLF|Ensembl=ENSCAFG00000009203|UniProtKB=F1PVZ1	Muscarinic acetylcholine receptor	ISS	8100450	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P06664	Gonadotropin-releasing hormone receptor pathway	P06841	gnaq/11	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	RCA	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00048	PI3 kinase pathway	P01179	PKB	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	TAS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00054	Toll receptor signaling pathway	G01550	Gene trancription	MACMU|Ensembl=ENSMMUG00000016857|UniProtKB=F7BWZ9	Uncharacterized protein	ISS	97393071	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	RAT|RGD=1307193|UniProtKB=D3ZJP6	Unconventional myosin-X	ISS			PTHR13140:SF276	UNCONVENTIONAL MYOSIN-X
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	IC	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00011	Blood coagulation	P00406	Fibrinogen	HUMAN|HGNC=3662|UniProtKB=P02675	Fibrinogen beta chain	ISS	6575700	PubMed	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00057	Wnt signaling pathway	P01447	Dishevelled	CANLF|Ensembl=ENSCAFG00000012180|UniProtKB=F1PIB1	Uncharacterized protein	ISS	10409711	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05731	GABA-B receptor II signaling	P05752	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	NAS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01173	STAT	MACMU|Ensembl=ENSMMUG00000010707|UniProtKB=F7G8G5	Signal transducer and activator of transcription	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00034	Integrin signalling pathway	P00935	ILK	RAT|RGD=620063|UniProtKB=Q99J82	Integrin-linked protein kinase	ISS			PTHR44344:SF1	INTEGRIN-LINKED PROTEIN KINASE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MONDO|Ensembl=ENSMODG00000008826|UniProtKB=F6XUU0	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=88356|UniProtKB=P10287	Cadherin-3	IDA	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CHICK|Ensembl=ENSGALG00000011809|UniProtKB=F1NMB0	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	DICDI|dictyBase=DDB_G0283537|UniProtKB=P32254	Ras-like protein rasS	ISS	94119591	PubMed	PTHR24070:SF380	RAS-LIKE PROTEIN RASS
P00010	B cell activation	P00372	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	8262390	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P02738	De novo purine biosynthesis	P02909	GDP reductase	PANTR|Ensembl=ENSPTRG00000003207|UniProtKB=H2Q2Y0	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00005	Angiogenesis	P00218	STAT1	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	ISS	14984365	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00046	Oxidative stress response	P01135	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	TAS	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IC	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00053	T cell activation	P01319	PAK	RAT|RGD=3250|UniProtKB=P35465	Serine/threonine-protein kinase PAK 1	ISS	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00005	Angiogenesis	P00236	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=109356|UniProtKB=O09044	Synaptosomal-associated protein 23	IC	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00005	Angiogenesis	P00223	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04569	Cdc42	HUMAN|HGNC=1736|UniProtKB=P60953	Cell division control protein 42 homolog	IDA	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P02736	Coenzyme A biosynthesis	P02886	Pantetheine-phosphate adenyltransferase	RHOBA|EnsemblGenome=RB10654|UniProtKB=Q7UKG6	Phosphopantetheine adenylyltransferase	ISS			PTHR21342:SF1	PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	CAEEL|WormBase=WBGene00004344|UniProtKB=P34295	Regulator of G-protein signaling rgs-1	IDA	8756726	PubMed	PTHR10845:SF192	AXIN-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	TAKRU|Ensembl=ENSTRUG00000016101|UniProtKB=H2UW32	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00063	DBH	PANTR|Ensembl=ENSPTRG00000021521|UniProtKB=H2QY46	Uncharacterized protein	ISS	90219125	PubMed	PTHR10157:SF29	DOPAMINE BETA-HYDROXYLASE
P04397	p53 pathway by glucose deprivation	P04641	Akt	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	ISS	12655147	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00048	PI3 kinase pathway	P01192	p110	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=3763|UniProtKB=P30680	Somatostatin receptor type 2	IDA	12181435	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04556	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IDA	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	IC	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000023202|UniProtKB=F7EU36	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01211	ERK	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	IDA	19114921	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00019	Endothelin signaling pathway	P00591	PLCbeta	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04393	Ras Pathway	P04553	PAK	MACMU|Ensembl=ENSMMUG00000012033|UniProtKB=F7GWI2	Serine/threonine-protein kinase PAK 2	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	SCHPO|PomBase=SPBC12D12.04c|UniProtKB=P36583	Protein kinase C-like 2	IC	125549	gi	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DANRE|ZFIN=ZDB-GENE-030131-55|UniProtKB=Q6XNL8	Actin	IDA	11889126	PubMed	PTHR11937:SF263	ACTIN
P00045	Notch signaling pathway	P01103	Next	PANTR|Ensembl=ENSPTRG00000013250|UniProtKB=H2QJZ0	Delta-like protein	ISS	8955070	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MACMU|Ensembl=ENSMMUG00000010266|UniProtKB=F6PV18	Uncharacterized protein	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00004	Alzheimer disease-presenilin pathway	P00117	E-cadherin C-terminal fragment	PANTR|Ensembl=ENSPTRG00000008269|UniProtKB=H2QBE4	Cadherin 3, type 1, P-cadherin (Placental)	ISS	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	20216076	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00037	Ionotropic glutamate receptor pathway	P01021	Vglut	MONDO|Ensembl=ENSMODG00000009304|UniProtKB=F6YX10	Uncharacterized protein	ISS	12815758	PubMed	PTHR11662:SF201	VESICULAR GLUTAMATE TRANSPORTER 2
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	DROME|FlyBase=FBgn0260964|UniProtKB=Q8IH57	GH10249p	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P04393	Ras Pathway	P04543	MEKK1/4	BOVIN|Ensembl=ENSBTAG00000020079|UniProtKB=F1N3T0	Uncharacterized protein	ISS	9305639	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00023	General transcription regulation	P00668	TFIIB	MOUSE|MGI=MGI=1913903|UniProtKB=Q3UAW9	Transcription factor IIIB 50 kDa subunit	ISS			PTHR11618:SF5	TRANSCRIPTION FACTOR IIIB 50 KDA SUBUNIT
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00383	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	DROME|FlyBase=FBgn0026438|UniProtKB=E1JHQ6	Excitatory amino acid transporter 2, isoform C	IC	94365697	PubMed	PTHR11958:SF89	EXCITATORY AMINO ACID TRANSPORTER 2, ISOFORM C
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00045	Notch signaling pathway	G01541	E(spl)-C genes	PANTR|Ensembl=ENSPTRG00000000574|UniProtKB=H2PYQ8	Hairy/enhancer-of-split related with YRPW motif-like	ISS	10860664	PubMed	PTHR10985:SF79	HAIRY/ENHANCER-OF-SPLIT RELATED WITH YRPW MOTIF-LIKE PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	PANTR|Ensembl=ENSPTRG00000001787|UniProtKB=H2Q0T0	Phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00019	Endothelin signaling pathway	P00589	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	IGI	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	RAT|RGD=2321905|UniProtKB=D4ACM8	Protein Fzd7	ISS	11212302	PubMed	PTHR11309:SF31	FRIZZLED-7
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	CHICK|Ensembl=ENSGALG00000000889|UniProtKB=R9PXL1	Uncharacterized protein	IDA	10806215	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00030	Hypoxia response via HIF activation	P00823	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	96009592	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01162	MEK	CAEBR|Gene=CBG04190|UniProtKB=A8WWD7	Protein CBR-MEK-2	ISS	12024031	PubMed	PTHR24361:SF629	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00045	Notch signaling pathway	P01119	NIct	CANLF|Ensembl=ENSCAFG00000019633|UniProtKB=F1PDC7	Uncharacterized protein	ISS	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00056	VEGF signaling pathway	P01408	Akt/PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00005	Angiogenesis	P00236	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS			PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00048	PI3 kinase pathway	P01199	Galpha	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	IC	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02775	Salvage pyrimidine ribonucleotides	P03150	Uridine kinase	BOVIN|Ensembl=ENSBTAG00000015798|UniProtKB=E1BP85	Uridine kinase	ISS			PTHR10285:SF68	URIDINE-CYTIDINE KINASE-LIKE 1
P00029	Huntington disease	P00778	NMDA receptor	CAEBR|Gene=CBG02401|UniProtKB=A8WUE7	Protein CBR-NMR-1	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	PANTR|Ensembl=ENSPTRG00000004321|UniProtKB=H2R3M8	Proprotein convertase subtilisin/kexin type 7	ISS			PTHR42884:SF12	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 7
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02913	Thymidylate synthase	CANAL|CGD=CAL0000189182|UniProtKB=P12461	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	ANOGA|EnsemblGenome=AGAP000445|UniProtKB=Q7PRU8	AGAP000445-PA	IDA	12106606	PubMed	PTHR24246:SF27	ADENOSINE RECEPTOR A2A
P00010	B cell activation	P00373	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01173	STAT	MACMU|Ensembl=ENSMMUG00000010705|UniProtKB=F7G8V4	Signal transducer and activator of transcription	ISS	7514531	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00047	PDGF signaling pathway	P01159	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	XENTR|Xenbase=XB-GENE-479036|UniProtKB=Q640R7	Ras-related protein Rap-1b	ISS	10476970	PubMed	PTHR24070:SF382	RAS-RELATED PROTEIN RAP-1B
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	CHLRE|EnsemblGenome=CHLREDRAFT_129468|UniProtKB=A8IVZ9	Glutamine synthetase	ISS			PTHR20852:SF57	GLUTAMINE SYNTHETASE 2 CYTOPLASMIC
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00036	Interleukin signaling pathway	P00990	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05754	Ggamma	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P06587	Nicotine pharmacodynamics pathway	P06590	GNG	TAKRU|Ensembl=ENSTRUG00000007253|UniProtKB=H2SZQ1	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	HUMAN|HGNC=19663|UniProtKB=Q9UBI6	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00019	Endothelin signaling pathway	P00568	PKC	DANRE|ZFIN=ZDB-GENE-030131-6503|UniProtKB=Q7ZUC5	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF297	PROTEIN KINASE C DELTA TYPE
P00004	Alzheimer disease-presenilin pathway	P00141	Membrane metalloprotease	BOVIN|Gene=MMP14|UniProtKB=Q9GLE4	Matrix metalloproteinase-14	TAS	12834808	PubMed	PTHR10201:SF24	MATRIX METALLOPROTEINASE-14
P00021	FGF signaling pathway	P00645	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00021	FGF signaling pathway	P00627	ERK1-2	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02747	Histidine biosynthesis	P02987	ATP phosphoribosyl transferase	AQUAE|EnsemblGenome=aq_1613|UniProtKB=O67543	ATP phosphoribosyltransferase	ISS			PTHR21403:SF4	ATP PHOSPHORIBOSYLTRANSFERASE
P00034	Integrin signalling pathway	P00940	Src	CAEBR|Gene=CBG22259|UniProtKB=A8Y1X2	Tyrosine-protein kinase	ISS	8054685	PubMed	PTHR24418:SF308	TYROSINE PROTEIN-KINASE SRC-1
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00012	Cadherin signaling pathway	P00475	Frizzled	HUMAN|HGNC=4041|UniProtKB=Q9NPG1	Frizzled-3	IDA	11212302	PubMed	PTHR11309:SF22	FRIZZLED-3
P05731	GABA-B receptor II signaling	P05760	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00021	FGF signaling pathway	P00648	PKC	CANAL|CGD=CAL0003231|UniProtKB=Q5ANK2	Protein kinase C	IGI	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	PANTR|Gene=ALDOA|UniProtKB=A5A6I5	Fructose-bisphosphate aldolase A	ISS	84261525	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	BOVIN|Ensembl=ENSBTAG00000013099|UniProtKB=Q3ZBY4	Fructose-bisphosphate aldolase	ISS	7768978	PubMed	PTHR11627:SF3	FRUCTOSE-BISPHOSPHATE ALDOLASE C
P05731	GABA-B receptor II signaling	P05754	Ggamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00058	mRNA splicing	P01476	U4	PANTR|Ensembl=ENSPTRG00000001254|UniProtKB=G2HGL9	PRP3 pre-mRNA processing factor 3 homolog	ISS	12875835	PubMed	PTHR14212:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00005	Angiogenesis	P00193	SOS-1	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01208	Hsp70	ANOGA|EnsemblGenome=AGAP004192|UniProtKB=Q7PQK5	AGAP004192-PA	IDA	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g236559|UniProtKB=A7RRG4	Actin-related protein 2/3 complex subunit 4	ISS	5031595	gi	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P02729	Ascorbate degradation	P02852	L-xylulose-5-phosphate-3-epimerase	ECOLI|EcoGene=EG11957|UniProtKB=P32719	D-allulose-6-phosphate 3-epimerase	ISS			PTHR11749:SF3	RIBULOSE-PHOSPHATE 3-EPIMERASE
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	YEAST|SGD=S000003272|UniProtKB=P14681	Mitogen-activated protein kinase KSS1	TAS			PTHR24055:SF338	MITOGEN-ACTIVATED PROTEIN KINASE KSS1
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00056	VEGF signaling pathway	P01402	MEK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS			PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00927	Rac	DICPU|Gene=DICPUDRAFT_55703|UniProtKB=F0ZN94	Putative uncharacterized protein racC	ISS	94124042	PubMed	PTHR24072:SF117	RHO-RELATED PROTEIN RACC
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	NEUCR|EnsemblGenome=EFNCRG00000006348|UniProtKB=P48580	Serine/threonine-protein phosphatase PP2A catalytic subunit	ISS			PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00015	Circadian clock system	P00502	Casein kinase I	PANTR|Ensembl=ENSPTRG00000014365|UniProtKB=H2R0C8	Casein kinase 1, epsilon	ISS	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00020	FAS signaling pathway	P00620	CytochromeC	CAEEL|WormBase=WBGene00000869|UniProtKB=Q18853	CYtochrome C	IGI	9027315	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00006	Apoptosis signaling pathway	P00297	NFkappaB	CANLF|Ensembl=ENSCAFG00000010155|UniProtKB=E2RLL2	Uncharacterized protein	ISS	12574369	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00029	Huntington disease	P00807	Actin	RAT|RGD=2026|UniProtKB=P68035	Actin, alpha cardiac muscle 1	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IDA	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02782	Triacylglycerol metabolism	P03205	Triacylglycerol lipase	MACMU|Ensembl=ENSMMUG00000017916|UniProtKB=F7EWI0	Uncharacterized protein	ISS			PTHR23025:SF3	HORMONE-SENSITIVE LIPASE
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IGI	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	MOUSE|MGI=MGI=1930182|UniProtKB=Q9WV85	Nucleoside diphosphate kinase 3	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00006	Apoptosis signaling pathway	P00261	Bok	RAT|RGD=70984|UniProtKB=Q792S6	Bcl-2-related ovarian killer protein	ISS	9356461	PubMed	PTHR11256:SF48	BCL-2-RELATED OVARIAN KILLER PROTEIN
P00059	p53 pathway	P04630	PP2A	CHICK|Ensembl=ENSGALG00000010273|UniProtKB=P48463	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	1662645	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00260	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	ARATH|TAIR=AT5G03730|UniProtKB=Q05609	Serine/threonine-protein kinase CTR1	ISS			PTHR44329:SF1	SERINE/THREONINE-PROTEIN KINASE CTR1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P05916	Opioid prodynorphin pathway	P06002	G-protein	MONDO|Ensembl=ENSMODG00000000771|UniProtKB=F6SSS3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00018	EGF receptor signaling pathway	P00558	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IGI	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00056	VEGF signaling pathway	P01411	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	RAT|RGD=620218|UniProtKB=P15337	Cyclic AMP-responsive element-binding protein 1	ISS	1354612	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00049	Parkinson disease	P01230	Src kinase	MOUSE|MGI=MGI=96892|UniProtKB=P25911	Tyrosine-protein kinase Lyn	IDA	11078745	PubMed	PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02743	Formyltetrahydroformate biosynthesis	P02952	Methylene tetrahydrofolate dehydrogenase	CANLF|Ensembl=ENSCAFG00000008716|UniProtKB=E2RQ65	Uncharacterized protein	ISS			PTHR10025:SF39	BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, MITOCHONDRIAL
P00060	Ubiquitin proteasome pathway	P01492	E1	MOUSE|MGI=MGI=1858313|UniProtKB=Q9Z1F9	SUMO-activating enzyme subunit 2	ISS			PTHR10953:SF5	SUMO-ACTIVATING ENZYME SUBUNIT 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	MACMU|Ensembl=ENSMMUG00000014486|UniProtKB=F7GH95	Ras-related protein Rap-1A	ISS	10476970	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P05913	Enkephalin release	P05972	PKA	LEIMA|EnsemblGenome=LmjF.18.1080|UniProtKB=Q27687	Protein kinase A catalytic subunit	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01159	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04393	Ras Pathway	P04557	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00021	FGF signaling pathway	P00637	MKK4,7	HUMAN|HGNC=6844|UniProtKB=P45985	Dual specificity mitogen-activated protein kinase kinase 4	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00022	General transcription by RNA polymerase I	P00652	RNA Polymerase I  Complex	MACMU|Ensembl=ENSMMUG00000004385|UniProtKB=F7FMW4	DNA-directed RNA polymerases I, II, and III subunit RPABC4	ISS	12634356	PubMed	PTHR12056:SF2	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC4
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	BOVIN|Ensembl=ENSBTAG00000002081|UniProtKB=A7YWG6	Serine/threonine-protein kinase receptor	ISS	10683140	PubMed	PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MACMU|Ensembl=ENSMMUG00000006912|UniProtKB=F7EZ48	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF86	FRIZZLED-10
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	TAS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00029	Huntington disease	P00805	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04397	p53 pathway by glucose deprivation	P04641	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00402	Jnk	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	CAEEL|WormBase=WBGene00002335|UniProtKB=P22981	Ras protein let-60	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00021	FGF signaling pathway	P00640	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00001	Adrenaline and noradrenaline biosynthesis	P00066	DOPA decarb.	RAT|RGD=2494|UniProtKB=P14173	Aromatic-L-amino-acid decarboxylase	ISS	7567987	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	STRPU|Gene=CYIIIA|UniProtKB=P53474	Actin, cytoskeletal 3A	IDA	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01177	P110ACT	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01143	ERK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00545	JNK1-3	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	HUMAN|HGNC=1736|UniProtKB=P60953	Cell division control protein 42 homolog	IDA	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00021	FGF signaling pathway	P00644	p38	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	8920915	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00018	EGF receptor signaling pathway	P00562	p38	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	8920915	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	TAS	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00018	EGF receptor signaling pathway	P00562	p38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	IGI	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	HALSA|EnsemblGenome=VNG_2384G|UniProtKB=Q9HMU3	Ribonucleoside reductase large chain	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	RAT|RGD=2732|UniProtKB=P22756	Glutamate receptor ionotropic, kainate 1	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01072	CHT1	MACMU|Ensembl=ENSMMUG00000010166|UniProtKB=F6QHN1	Uncharacterized protein	ISS	12675135	PubMed	PTHR11819:SF129	HIGH AFFINITY CHOLINE TRANSPORTER 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	IC	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00547	PP2A	MACMU|Ensembl=ENSMMUG00000000186|UniProtKB=F7ANY1	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P00059	p53 pathway	G01579	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00748	Gbeta5L	MOUSE|MGI=MGI=101848|UniProtKB=P62881	Guanine nucleotide-binding protein subunit beta-5	IDA	10051575	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00029	Huntington disease	P00770	N-CoR	HUMAN|HGNC=7673|UniProtKB=Q9Y618	Nuclear receptor corepressor 2	IPI	10441327	PubMed	PTHR13992:SF21	NUCLEAR RECEPTOR COREPRESSOR 2
P00021	FGF signaling pathway	P00644	p38	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	IDA	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	XENTR|Xenbase=XB-GENE-481480|UniProtKB=Q5XGI6	Casein kinase 1, epsilon	ISS	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01446	Calcineurin	YEAST|SGD=S000004425|UniProtKB=P23287	Serine/threonine-protein phosphatase 2B catalytic subunit A1	IDA	12015605	PubMed	PTHR11668:SF118	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00560	Raf-1	TAKRU|Ensembl=ENSTRUG00000006611|UniProtKB=H2SV11	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00084	X11alpha	MOUSE|MGI=MGI=1261791|UniProtKB=P98084	Amyloid beta A4 precursor protein-binding family A member 2	IDA	9614075	PubMed	PTHR12345:SF12	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 2
P00045	Notch signaling pathway	P01099	Notch	HUMAN|HGNC=7883|UniProtKB=Q9UM47	Neurogenic locus notch homolog protein 3	IC	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00830	Lipoxygenase	RAT|RGD=2097|UniProtKB=P20291	Arachidonate 5-lipoxygenase-activating protein	ISS	11937571	PubMed	PTHR10250:SF2	ARACHIDONATE 5-LIPOXYGENASE-ACTIVATING PROTEIN
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	ISS	11554549	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MOUSE|MGI=MGI=104589|UniProtKB=P63268	Actin, gamma-enteric smooth muscle	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00029	Huntington disease	P00790	beta-Tubulin	ORYSJ|EnsemblGenome=OS01G0805900|UniProtKB=P45960	Tubulin beta-4 chain	TAS	12932731	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P05730	Endogenous cannabinoid signaling	P05751	Galpha	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANAL|CGD=CAL0006065|UniProtKB=Q59LC4	Phosphoinositide phospholipase C	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	RAT|RGD=1307040|UniProtKB=F1LP57	Protein Map2k4	ISS			PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00046	Oxidative stress response	P01135	p38	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	TAS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00053	T cell activation	P01315	Calcineurin	PANTR|Ensembl=ENSPTRG00000020059|UniProtKB=H2QVV0	Serine/threonine-protein phosphatase	ISS	12015605	PubMed	PTHR11668:SF186	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT GAMMA ISOFORM
P00021	FGF signaling pathway	P00624	14-3-3	MACMU|Ensembl=ENSMMUG00000000721|UniProtKB=F7H4H9	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	BOVIN|Ensembl=ENSBTAG00000013498|UniProtKB=Q75Z89	5-hydroxytryptamine receptor 2A	ISS	12181435	PubMed	PTHR24247:SF30	5-HYDROXYTRYPTAMINE RECEPTOR 2A
P00047	PDGF signaling pathway	P01161	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00057	Wnt signaling pathway	P01457	GBeta	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IGI	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00010	B cell activation	P00375	Calmodulin	NEMVE|Gene=v1g88970|UniProtKB=A7RPN8	Predicted protein (Fragment)	ISS			PTHR23050:SF245	AT16150P-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000012005|UniProtKB=F7H091	Metabotropic glutamate receptor 2 isoform a	ISS	20012997	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	HUMAN|HGNC=20778|UniProtKB=P07437	Tubulin beta chain	ISS	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00006	Apoptosis signaling pathway	P00325	Bim	MACMU|Ensembl=ENSMMUG00000018423|UniProtKB=F7HHA7	Bcl-2-like protein 11	ISS	11859372	PubMed	PTHR12044:SF9	BCL-2-LIKE PROTEIN 11
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00029	Huntington disease	P00807	Actin	SCHMA|EnsemblGenome=Smp_202970|UniProtKB=G4VLN1	Putative uncharacterized protein Smp_202970	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00005	Angiogenesis	P00237	FRP	MONDO|Ensembl=ENSMODG00000008701|UniProtKB=F6PWM3	Uncharacterized protein	ISS	12549854	PubMed	PTHR11309:SF22	FRIZZLED-3
P00019	Endothelin signaling pathway	P00588	ET1-4	RAT|RGD=2534|UniProtKB=P13207	Endothelin-3	ISS	88320556	PubMed	PTHR13874:SF11	ENDOTHELIN-3
P00005	Angiogenesis	P00218	STAT1	TAKRU|Ensembl=ENSTRUG00000000102|UniProtKB=H2RJA9	Signal transducer and activator of transcription	ISS	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00053	T cell activation	P01332	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	IDA	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00036	Interleukin signaling pathway	P00971	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12748278	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00005	Angiogenesis	P00182	p38MAPK	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PHYPA|Gene=PHYPADRAFT_226658|UniProtKB=A9TYG3	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CHICK|Ensembl=ENSGALG00000002098|UniProtKB=F1P0L4	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00053	T cell activation	P01306	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	HUMAN|HGNC=6091|UniProtKB=P06213	Insulin receptor	ISS	11182407	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00022	General transcription by RNA polymerase I	P00650	TAF-IB	MOUSE|MGI=MGI=109577|UniProtKB=P97358	TATA box-binding protein-associated factor RNA polymerase I subunit B	RCA			PTHR31576:SF2	TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B
P00048	PI3 kinase pathway	P01179	PKB	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01443	Phospholipase C	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00057	Wnt signaling pathway	P01446	Calcineurin	RAT|RGD=3382|UniProtKB=P63329	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	IDA	12091710	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04393	Ras Pathway	P04546	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	IDA	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04556	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	DAPPU|EnsemblGenome=DAPPUDRAFT_206575|UniProtKB=E9FUX0	Guanine nucleotide binding protein, beta subunit	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00005	Angiogenesis	P00199	JNKK1	MACMU|Ensembl=ENSMMUG00000019842|UniProtKB=F7FU91	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P05913	Enkephalin release	P05977	G-Protein (s)	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00059	p53 pathway	P04626	GADD45	PANTR|Ensembl=ENSPTRG00000000842|UniProtKB=H2R902	Growth arrest and DNA-damage-inducible, alpha	ISS	9827804	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P00009	Axon guidance mediated by netrin	P00366	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IC	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00047	PDGF signaling pathway	P01153	GSK3	CAEEL|WormBase=WBGene00008095|UniProtKB=Q93372	Uncharacterized protein	ISS			PTHR24057:SF20	SUBFAMILY NOT NAMED
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PHANO|EnsemblGenome=SNOG_01139|UniProtKB=H2KNE6	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00053	T cell activation	P01322	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02775	Salvage pyrimidine ribonucleotides	P03152	Uridine phosphorylase	PANTR|Ensembl=ENSPTRG00000019177|UniProtKB=H2QUK2	Uridine phosphorylase	ISS			PTHR43691:SF3	URIDINE PHOSPHORYLASE 1
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00010	B cell activation	P00369	MEKK	CANLF|Ensembl=ENSCAFG00000012934|UniProtKB=F1P750	Uncharacterized protein	ISS	8649450	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00050	Plasminogen activating cascade	P01256	uPAR	HUMAN|HGNC=9053|UniProtKB=Q03405	Urokinase plasminogen activator surface receptor	IEA	11875695	gi	PTHR10624:SF6	UROKINASE PLASMINOGEN ACTIVATOR SURFACE RECEPTOR
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MONDO|Ensembl=ENSMODG00000004422|UniProtKB=F6SCX2	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF344	MYOSIN-7
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	ARATH|TAIR=AT1G29900|UniProtKB=Q42601	Carbamoyl-phosphate synthase large chain, chloroplastic	ISS			PTHR11405:SF47	CARBAMOYL-PHOSPHATE SYNTHASE LARGE CHAIN, CHLOROPLASTIC
P04393	Ras Pathway	P04542	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	IC	8838325	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00018	EGF receptor signaling pathway	P00551	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	IGI	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	MACMU|Ensembl=ENSMMUG00000021075|UniProtKB=F7GY91	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	11535291	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00036	Interleukin signaling pathway	P00983	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	TAS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02781	Threonine biosynthesis	P03190	Threonine synthase	AQUAE|EnsemblGenome=aq_608|UniProtKB=O66864	Threonine synthase	ISS	9537320	PubMed	PTHR10314:SF96	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00784	MAPKK7	RAT|RGD=1560043|UniProtKB=Q4KSH7	Dual specificity mitogen-activated protein kinase kinase 7	RCA	15039780	PubMed	PTHR24361:SF387	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	DICDI|dictyBase=DDB_G0279911|UniProtKB=P34093	Nucleoside diphosphate kinase, mitochondrial	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00045	Notch signaling pathway	P01105	TACE	BOVIN|Ensembl=ENSBTAG00000005481|UniProtKB=Q10741	Disintegrin and metalloproteinase domain-containing protein 10	ISS			PTHR11905:SF4	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 10
P00046	Oxidative stress response	P01129	JNK1/2	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	HUMAN|HGNC=418|UniProtKB=P09972	Fructose-bisphosphate aldolase C	ISS	3105602	PubMed	PTHR11627:SF3	FRUCTOSE-BISPHOSPHATE ALDOLASE C
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00047	PDGF signaling pathway	P01142	p90RSK	BOVIN|Ensembl=ENSBTAG00000021741|UniProtKB=F1MNR5	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00053	T cell activation	P01306	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00024	Glycolysis	P00679	Aldolase	LEIMA|EnsemblGenome=LmjF.36.1260|UniProtKB=Q4Q1V0	Fructose-bisphosphate aldolase	ISS	20017533	PubMed	PTHR11627:SF20	FRUCTOSE-BISPHOSPHATE ALDOLASE
P00057	Wnt signaling pathway	P01435	SWI/SNF	DROME|FlyBase=FBgn0002783|UniProtKB=Q9VF03	Brahma associated protein 155 kDa	ISS	11532957	PubMed	PTHR12802:SF41	BRAHMA ASSOCIATED PROTEIN 155 KDA
P00048	PI3 kinase pathway	P01178	Grb2	CAEEL|WormBase=WBGene00004774|UniProtKB=P29355	Sex muscle abnormal protein 5	TAS	11457149	PubMed	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00029	Huntington disease	P00797	p53	HUMAN|HGNC=12003|UniProtKB=O15350	Tumor protein p73	TAS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00019	Endothelin signaling pathway	P00572	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00011	Blood coagulation	P00457	Thrombomodulin	RAT|RGD=621299|UniProtKB=O35370	Protein Thbd	ISS	13929084	gi	PTHR24036:SF5	THROMBOMODULIN
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000005917|UniProtKB=F6QM53	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00021	FGF signaling pathway	P00644	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	IPI	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00048	PI3 kinase pathway	P01199	Galpha	MONDO|Ensembl=ENSMODG00000001933|UniProtKB=F6W0P2	Uncharacterized protein (Fragment)	ISS			PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MACMU|Ensembl=ENSMMUG00000002368|UniProtKB=F7BZY1	Uncharacterized protein	ISS	12356903	PubMed	PTHR10177:SF67	G1/S-SPECIFIC CYCLIN-D1
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00474	Wnt	XENTR|Gene=wnt11b-1|UniProtKB=Q66II0	Protein Wnt-11b-1	ISS	11266476	PubMed	PTHR12027:SF34	PROTEIN WNT
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04393	Ras Pathway	P04552	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IDA	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00059	p53 pathway	P04630	PP2A	MONDO|Ensembl=ENSMODG00000014177|UniProtKB=F6U7A6	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	HUMAN|HGNC=4573|UniProtKB=P42263	Glutamate receptor 3	ISS	12941441	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	MOUSE|MGI=MGI=1916211|UniProtKB=Q9DB30	Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	IDA	1370475	PubMed	PTHR44087:SF2	PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, LIVER/TESTIS ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00054	Toll receptor signaling pathway	P01358	ERK1	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	SCHPO|PomBase=SPCC1223.08c|UniProtKB=P36591	Dihydrofolate reductase	ISS			PTHR22778:SF16	DIHYDROFOLATE REDUCTASE
P00045	Notch signaling pathway	P01109	Aph-1	HUMAN|HGNC=24080|UniProtKB=Q8WW43	Gamma-secretase subunit APH-1B	IDA	12763021	PubMed	PTHR12889:SF1	GAMMA-SECRETASE SUBUNIT APH-1B
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEEL|WormBase=WBGene00018620|UniProtKB=O44588	Uncharacterized protein	ISS	11880265	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	TAS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00036	Interleukin signaling pathway	P00977	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	TAKRU|Ensembl=ENSTRUG00000011297|UniProtKB=H2TV18	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_94959|UniProtKB=C3XYC4	Putative uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	HUMAN|HGNC=1077|UniProtKB=O00238	Bone morphogenetic protein receptor type-1B	TAS	9395284	PubMed	PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P00057	Wnt signaling pathway	P01463	Kremen	MOUSE|MGI=MGI=1933988|UniProtKB=Q99N43	Kremen protein 1	ISS			PTHR24269:SF13	KREMEN PROTEIN 1
P06211	BMP/activin signaling pathway-drosophila	P06250	I-Smad	DROME|FlyBase=FBgn0020493|UniProtKB=Q5U110	Mothers against decapentaplegic homolog	RCA	http://flybase.org/reports/FBgn0020493.html	Website	PTHR13703:SF44	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG
P00036	Interleukin signaling pathway	P00976	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00022	General transcription by RNA polymerase I	P00657	TBP	METAC|EnsemblGenome=MA_0278|UniProtKB=Q8TTZ7	TATA-box-binding protein 3	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00050	Plasminogen activating cascade	P01264	alpha2 antiplasmin	MOUSE|MGI=MGI=107173|UniProtKB=Q61247	Alpha-2-antiplasmin	ISS	6679383	gi	PTHR11461:SF20	ALPHA-2-ANTIPLASMIN
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	SYNY3|EnsemblGenome=BAA16727|UniProtKB=P72720	Glutamine--fructose-6-phosphate aminotransferase [isomerizing]	ISS			PTHR10937:SF0	GH12731P-RELATED
P02743	Formyltetrahydroformate biosynthesis	P02952	Methylene tetrahydrofolate dehydrogenase	PANTR|Ensembl=ENSPTRG00000012081|UniProtKB=H2QI58	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	ISS			PTHR10025:SF39	BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, MITOCHONDRIAL
P00047	PDGF signaling pathway	P01145	c-fos	BOVIN|Ensembl=ENSBTAG00000004322|UniProtKB=O77628	Proto-oncogene c-Fos	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00045	Notch signaling pathway	P01119	NIct	RAT|RGD=1303282|UniProtKB=Q6MG89	Notch homolog 4, [Drosophila]	ISS	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	HUMAN|HGNC=14131|UniProtKB=Q9P2W3	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13	IC	10391901	PubMed	PTHR15936:SF2	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-13
P00059	p53 pathway	P04633	P110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	IDA	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	RAT|RGD=3698|UniProtKB=P24942	Excitatory amino acid transporter 1	ISS	94365697	PubMed	PTHR11958:SF24	EXCITATORY AMINO ACID TRANSPORTER 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEEL|WormBase=WBGene00018620|UniProtKB=O44588	Uncharacterized protein	ISS	15572354	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P00006	Apoptosis signaling pathway	P00302	ATF	PANTR|Ensembl=ENSPTRG00000012660|UniProtKB=H2QJ07	Activating transcription factor 2	ISS	15218628	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04397	p53 pathway by glucose deprivation	P04641	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P02738	De novo purine biosynthesis	P02891	GDP kinase	PANTR|Ensembl=ENSPTRG00000017279|UniProtKB=H2QRJ9	Uncharacterized protein	ISS			PTHR11349:SF64	NUCLEOSIDE DIPHOSPHATE KINASE HOMOLOG 5
P00049	Parkinson disease	P01238	14-3-3	ANOGA|EnsemblGenome=AGAP001151|UniProtKB=Q7PX08	AGAP001151-PA	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00019	Endothelin signaling pathway	P00580	ET-RA/B	BOVIN|Ensembl=ENSBTAG00000005299|UniProtKB=P28088	Endothelin B receptor	ISS	1312214	PubMed	PTHR24243:SF30	ENDOTHELIN B RECEPTOR
P00012	Cadherin signaling pathway	P00474	Wnt	TAKRU|Ensembl=ENSTRUG00000011562|UniProtKB=H2TX02	Protein Wnt	IDA	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	MACMU|Ensembl=ENSMMUG00000019351|UniProtKB=Q2YEG0	C-X-C chemokine receptor type 1	ISS	1840701	PubMed	PTHR10489:SF916	C-X-C CHEMOKINE RECEPTOR TYPE 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	1499560	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	MONDO|Ensembl=ENSMODG00000015287|UniProtKB=F6T6M8	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00036	Interleukin signaling pathway	P00965	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02779	Thiamin biosynthesis	P03170	Hydroxymethylpyrimidine phosphate kinase	SCHPO|PomBase=SPBP8B7.18c|UniProtKB=O94266	Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 2	ISS			PTHR20858:SF17	HYDROXYMETHYLPYRIMIDINE/PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED
P00049	Parkinson disease	P01211	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00203	Erk	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00626	Spry	BOVIN|Ensembl=ENSBTAG00000008250|UniProtKB=A2VDU1	Protein sprouty homolog 4	ISS	22024232	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	TAS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000001583|UniProtKB=F7BBM1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02742	Tetrahydrofolate biosynthesis	P02951	GTP cyclohydrolase	DEIRA|EnsemblGenome=DR_0036|UniProtKB=Q9RYB4	GTP cyclohydrolase 1	ISS			PTHR11109:SF0	GTP CYCLOHYDROLASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CHLRE|EnsemblGenome=CHLREDRAFT_24392|UniProtKB=A8JAV1	Actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04393	Ras Pathway	P04559	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	8649368	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	BOVIN|Ensembl=ENSBTAG00000013632|UniProtKB=E1B965	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	PANTR|Ensembl=ENSPTRG00000012624|UniProtKB=H2QZG8	Uncharacterized protein	ISS	22028976	PubMed	PTHR13140:SF311	MYOSIN-IIIB
P06664	Gonadotropin-releasing hormone receptor pathway	P06740	BMPR-IA/IB/II	MOUSE|MGI=MGI=107191|UniProtKB=P36898	Bone morphogenetic protein receptor type-1B	RCA	10683140	PubMed	PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P06664	Gonadotropin-releasing hormone receptor pathway	P06820	alpha-beta integrin dimer	MOUSE|MGI=MGI=96610|UniProtKB=P09055	Integrin beta-1	RCA	10706722	PubMed	PTHR10082:SF28	INTEGRIN BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MACMU|Ensembl=ENSMMUG00000005876|UniProtKB=Q28524	Beta-3 adrenergic receptor	IDA	12063255	PubMed	PTHR24248:SF3	BETA-3 ADRENERGIC RECEPTOR
P02746	Heme biosynthesis	P02975	Uroporphyrinogen decarboxylase	AQUAE|EnsemblGenome=aq_334|UniProtKB=O66667	Uroporphyrinogen decarboxylase	ISS			PTHR21091:SF2	UROPORPHYRINOGEN DECARBOXYLASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00029	Huntington disease	P00796	Kainate receptor	RAT|RGD=71027|UniProtKB=P42264	Glutamate receptor ionotropic, kainate 3	IDA	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00034	Integrin signalling pathway	P00947	Laminin	PANTR|Ensembl=ENSPTRG00000014912|UniProtKB=H2QMK9	Uncharacterized protein	ISS	2538453	PubMed	PTHR10574:SF36	LAMININ SUBUNIT BETA-2
P00057	Wnt signaling pathway	P01451	Galpha	HUMAN|HGNC=4383|UniProtKB=P30679	Guanine nucleotide-binding protein subunit alpha-15	IDA	11359849	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P00047	PDGF signaling pathway	P01174	Rho	PANTR|Ensembl=ENSPTRG00000003550|UniProtKB=H2Q3I0	Rho GTPase activating protein 1	ISS	14724572	PubMed	PTHR23176:SF28	RHO GTPASE-ACTIVATING PROTEIN 1
P00059	p53 pathway	G04694	p110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00054	Toll receptor signaling pathway	P01369	MKK1	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00012	Cadherin signaling pathway	P00477	GSK3beta	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00056	VEGF signaling pathway	P01425	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	3755548	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P02771	Pyrimidine Metabolism	P03126	Nucleoside Phosphorylase	METAC|EnsemblGenome=MA_3242|UniProtKB=Q8TL01	AMP phosphorylase	ISS	12125824	PubMed	PTHR10515:SF0	THYMIDINE PHOSPHORYLASE
P00021	FGF signaling pathway	P00640	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	12660731	PubMed	PTHR10048:SF14	PI-3 KINASE
P00056	VEGF signaling pathway	P01407	Erk	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=3233|UniProtKB=P33533	Delta-type opioid receptor	IDA	12093103	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00029	Huntington disease	P00776	c-Jun	CHICK|Gene=JUN|UniProtKB=P18870	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P02753	Methionine biosynthesis	P03024	Homocysteine transmethylase	DROME|FlyBase=FBgn0032726|UniProtKB=Q9VJ32	FI01821p	ISS			PTHR21091:SF123	FI01821P
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	ISS	15860573	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00018	EGF receptor signaling pathway	P00560	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00590	IP3 R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	BOVIN|Gene=CACNB1|UniProtKB=Q9MZL7	Voltage-dependent L-type calcium channel subunit beta-1	IC	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P04397	p53 pathway by glucose deprivation	P04641	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02749	Leucine biosynthesis	P03002	Isopropylmalate isomerase	DEIRA|EnsemblGenome=DR_1778|UniProtKB=Q9RTI6	3-isopropylmalate dehydratase large subunit 2	ISS			PTHR43822:SF2	HOMOACONITASE, MITOCHONDRIAL
P00047	PDGF signaling pathway	P01171	PLCgamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	PANTR|Ensembl=ENSPTRG00000019116|UniProtKB=H2QUH0	Inhibin, beta A	ISS	9395284	PubMed	PTHR11848:SF133	INHIBIN BETA A CHAIN
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	TAS	12719720	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00047	PDGF signaling pathway	P01145	c-fos	BOVIN|Ensembl=ENSBTAG00000004322|UniProtKB=O77628	Proto-oncogene c-Fos	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00059	p53 pathway	P01486	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	BOVIN|Ensembl=ENSBTAG00000002283|UniProtKB=F1N4K7	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF31	FRIZZLED-7
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P05912	Dopamine receptor mediated signaling pathway	P05970	TH	RAT|RGD=3853|UniProtKB=P04177	Tyrosine 3-monooxygenase	ISS	12814656	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00059	p53 pathway	P04623	CBP	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	IDA	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00474	Wnt	DROME|FlyBase=FBgn0004009|UniProtKB=P09615	Protein wingless	IDA	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00049	Parkinson disease	P01219	SAPK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05731	GABA-B receptor II signaling	P05753	Ca channel	HUMAN|HGNC=1388|UniProtKB=O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	14624853	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00029	Huntington disease	P00774	Dynein complex	PANTR|Ensembl=ENSPTRG00000014996|UniProtKB=H2QMR3	Uncharacterized protein	ISS	9454836	PubMed	PTHR10676:SF358	DYNEIN HEAVY CHAIN 1, AXONEMAL
P00049	Parkinson disease	P01219	SAPK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	NAS	11707292	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	CANLF|Ensembl=ENSCAFG00000018564|UniProtKB=E2RHU1	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00021	FGF signaling pathway	P00645	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12960248	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00866	Cytokine receptor	HUMAN|HGNC=5432|UniProtKB=P17181	Interferon alpha/beta receptor 1	IDA	12163451	PubMed	PTHR20859:SF54	INTERFERON ALPHA/BETA RECEPTOR 1
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05913	Enkephalin release	P05973	GPCR (i)	CANLF|Ensembl=ENSCAFG00000011689|UniProtKB=E2QZY2	Uncharacterized protein	ISS	11259487	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IDA	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00045	Notch signaling pathway	G01541	E(spl)-C genes	MACMU|Ensembl=ENSMMUG00000009491|UniProtKB=F6YUA8	Hairy/enhancer-of-split related with YRPW motif protein 2	ISS			PTHR10985:SF88	HAIRY/ENHANCER-OF-SPLIT RELATED WITH YRPW MOTIF PROTEIN 2
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00025	Hedgehog signaling pathway	P00692	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	MOUSE|MGI=MGI=88399|UniProtKB=P32211	Muscarinic acetylcholine receptor M4	ISS	91373358	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00047	PDGF signaling pathway	P01154	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P00059	p53 pathway	G01569	Maspin	MACMU|Ensembl=ENSMMUG00000014182|UniProtKB=F7ASZ9	Peptidase inhibitor 5	ISS	10692390	PubMed	PTHR11461:SF55	SERPIN B5
P04393	Ras Pathway	P04551	RalGDS	MACMU|Ensembl=ENSMMUG00000015274|UniProtKB=F7DUZ5	Uncharacterized protein	ISS	7809086	PubMed	PTHR23113:SF35	RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	ARATH|TAIR=AT2G30910|UniProtKB=O80856	Actin-related protein 2/3 complex subunit 1A	ISS	12963527	gi	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P05731	GABA-B receptor II signaling	P05754	Ggamma	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02756	N-acetylglucosamine metabolism	P03041	Glucosamine-6-phosphate deaminase	CHICK|Ensembl=ENSGALG00000014210|UniProtKB=E1C878	Glucosamine-6-phosphate isomerase	ISS			PTHR11280:SF9	GLUCOSAMINE-6-PHOSPHATE ISOMERASE 2
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	BOVIN|Ensembl=ENSBTAG00000020887|UniProtKB=F1MP22	Uncharacterized protein	ISS	14507926	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00005	Angiogenesis	P00211	GSK3beta	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IDA	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00005	Angiogenesis	P00226	Delta/Serrate	ORNAN|Ensembl=ENSOANG00000008425|UniProtKB=F6VUQ4	Delta-like protein	ISS	8955070	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00059	p53 pathway	P04609	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00057	Wnt signaling pathway	P01447	Dishevelled	HUMAN|HGNC=3086|UniProtKB=O14641	Segment polarity protein dishevelled homolog DVL-2	ISS	10409711	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00006	Apoptosis signaling pathway	P00268	GCK	RAT|RGD=1562028|UniProtKB=D3ZHL6	Mitogen-activated protein kinase kinase kinase kinase	ISS			PTHR24361:SF324	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 5
P00034	Integrin signalling pathway	P00932	FAK	MOUSE|MGI=MGI=104908|UniProtKB=Q9QVP9	Protein-tyrosine kinase 2-beta	IPI	12640026	PubMed	PTHR24418:SF94	PROTEIN-TYROSINE KINASE 2-BETA
P00029	Huntington disease	P00777	CBP	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2744|UniProtKB=P31422	Metabotropic glutamate receptor 3	IDA	9407094	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	HUMAN|HGNC=19663|UniProtKB=Q9UBI6	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IDA	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MONDO|Ensembl=ENSMODG00000004422|UniProtKB=F6SCX2	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF344	MYOSIN-7
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DICDI|dictyBase=DDB_G0289489|UniProtKB=P07828	Actin-18	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	MACMU|Ensembl=ENSMMUG00000022009|UniProtKB=F6RBZ7	Cell division control protein 42 homolog isoform 2	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	BOVIN|Ensembl=ENSBTAG00000013555|UniProtKB=F1MSQ2	Receptor protein serine/threonine kinase	ISS			PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=94926|UniProtKB=P51436	D(4) dopamine receptor	IDA	2137198	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	MACMU|Ensembl=ENSMMUG00000003145|UniProtKB=F7EPF6	Uncharacterized protein	ISS	2433589	PubMed	PTHR11767:SF52	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 4
P00057	Wnt signaling pathway	P01438	PP2A	MOUSE|MGI=MGI=2388480|UniProtKB=Q6PD28	Protein Ppp2r5b	ISS	11531413	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	CANLF|Ensembl=ENSCAFG00000018564|UniProtKB=E2RHU1	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00036	Interleukin signaling pathway	P00997	Shc	MOUSE|MGI=MGI=98296|UniProtKB=P98083	SHC-transforming protein 1	IGI	10982827	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	PANTR|Ensembl=ENSPTRG00000007887|UniProtKB=H2QAR9	Glutamyl-tRNA synthetase 2, mitochondrial (Putative)	ISS			PTHR43311:SF2	GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	RAT|RGD=3567|UniProtKB=P49799	Regulator of G-protein signaling 4	ISS	9774420	PubMed	PTHR10845:SF184	REGULATOR OF G-PROTEIN SIGNALING 4
P00018	EGF receptor signaling pathway	P00540	MKK3,6	ORNAN|Ensembl=ENSOANG00000007732|UniProtKB=F6PXH5	Uncharacterized protein (Fragment)	ISS	11971971	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00049	Parkinson disease	P01219	SAPK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	NAS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00045	Notch signaling pathway	P01113	Pen-2	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	ISS	9332390	PubMed	PTHR10202:SF13	PRESENILIN-2
P04398	p53 pathway feedback loops 2	G04711	SIAH-1	MACMU|Ensembl=ENSMMUG00000007400|UniProtKB=F6T3K3	E3 ubiquitin-protein ligase	ISS	11389839	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00021	FGF signaling pathway	P00629	PP2A	ORYSJ|EnsemblGenome=OS10G0476600|UniProtKB=Q7XDE0	EF hand family protein, expressed	ISS			PTHR14095:SF0	SERINE/THREONINE PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B''ALPHA-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00046	Oxidative stress response	P01132	c-jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00006	Apoptosis signaling pathway	P00313	IKK	MACMU|Ensembl=ENSMMUG00000018476|UniProtKB=F6X938	Uncharacterized protein	ISS	12235208	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00029	Huntington disease	P00777	CBP	ARATH|TAIR=AT3G12980|UniProtKB=Q9LE42	Histone acetyltransferase HAC5	IDA	8413673	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	BACSU|EnsemblGenome=BSU22730|UniProtKB=P31103	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00060	Ubiquitin proteasome pathway	P01490	E3	RAT|RGD=1306361|UniProtKB=F1M7B8	Protein Ube3a	ISS			PTHR11254:SF301	UBIQUITIN-PROTEIN LIGASE E3A
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000012005|UniProtKB=F7H091	Metabotropic glutamate receptor 2 isoform a	ISS	12488551	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=1336171|UniProtKB=Q9DAS9	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P02727	Androgen/estrogene/progesterone biosynthesis	P02837	3beta-hydroxy-Delta5-steroid dehydrogenase	DANRE|ZFIN=ZDB-GENE-030131-5673|UniProtKB=F1QEV3	Uncharacterized protein	ISS			PTHR10366:SF387	3 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 7
P00048	PI3 kinase pathway	P01188	Gbetagamma	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00005	Angiogenesis	P00233	CSL	XENTR|Xenbase=XB-GENE-490756|UniProtKB=F7BXC9	Uncharacterized protein (Fragment)	ISS	9043084	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P05730	Endogenous cannabinoid signaling	P05751	Galpha	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	ARATH|TAIR=AT1G08700|UniProtKB=O64668	Presenilin-like protein At1g08700	TAS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00018	EGF receptor signaling pathway	P00546	GAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	11847220	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	EMENI|EnsemblGenome=CADANIAG00002552|UniProtKB=Q12526	Ras-like protein	ISS	7997267	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	SYNY3|EnsemblGenome=BAA10403|UniProtKB=Q55756	Carbamoyl-phosphate synthase large chain	ISS			PTHR11405:SF5	CAD PROTEIN
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	MOUSE|MGI=MGI=88296|UniProtKB=O55017	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	14507926	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CANLF|Ensembl=ENSCAFG00000013755|UniProtKB=Q49LX5	Somatostatin receptor type 1	ISS	12441358	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02738	De novo purine biosynthesis	P02908	Phosphoribosylamine glycine ligase	ECOLI|EcoGene=EG10792|UniProtKB=P15640	Phosphoribosylamine--glycine ligase	ISS			PTHR43472:SF1	PHOSPHORIBOSYLAMINE--GLYCINE LIGASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	TAS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P02769	Purine metabolism	P03119	5'-Nucleotidase	PANTR|Ensembl=ENSPTRG00000018391|UniProtKB=H2QTC9	5'-nucleotidase, ecto (CD73)	ISS	8224905	PubMed	PTHR11575:SF25	5'-NUCLEOTIDASE
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02723	Adenine and hypoxanthine salvage pathway	P02805	Adenine phosphorylase	CAEBR|Gene=CBG13501|UniProtKB=A8XI15	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00036	Interleukin signaling pathway	P00990	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00021	FGF signaling pathway	P00642	MEK1-2	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00053	T cell activation	P01303	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	15210125	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06799	TAK1	MOUSE|MGI=MGI=1346877|UniProtKB=Q62073	Mitogen-activated protein kinase kinase kinase 7	RCA	10683140	PubMed	PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P00055	Transcription regulation by bZIP transcription factor	P01386	TFIIEbeta	CAEEL|WormBase=WBGene00010054|UniProtKB=G5EG47	Transcription initiation factor IIE subunit beta	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	XENTR|Xenbase=XB-GENE-484098|UniProtKB=F6ZQ88	Protein Wnt (Fragment)	ISS	11266476	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00019	Endothelin signaling pathway	P00578	eNOS	MACMU|Ensembl=ENSMMUG00000020437|UniProtKB=F6WEB2	Nitric oxide synthase	ISS	9837777	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	HUMAN|HGNC=9509|UniProtKB=P49810	Presenilin-2	TAS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00010	B cell activation	P00391	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00230	PDGFR	BOVIN|Ensembl=ENSBTAG00000007173|UniProtKB=F1MX49	Platelet-derived growth factor receptor alpha	ISS	12374780	PubMed	PTHR24416:SF52	PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	PANTR|Ensembl=ENSPTRG00000034379|UniProtKB=H2RDK4	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00021	FGF signaling pathway	P00644	p38	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	IGI	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ORYSJ|Gene=Os01g0866100|UniProtKB=P0C540	Actin-7	IC	14684598	PubMed	PTHR11937:SF205	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF31	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00177	Nectin 1alpha C-terminal fragment	MACMU|Ensembl=ENSMMUG00000008274|UniProtKB=F7HBK1	Uncharacterized protein	ISS	12376527	PubMed	PTHR23277:SF69	NECTIN-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IDA	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02770	Pyridoxal phosphate salvage pathway	P03123	Pyridoxine-5-phosphate oxidase	CANLF|Ensembl=ENSCAFG00000016814|UniProtKB=E2QTE2	Uncharacterized protein	ISS	14697241	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00047	PDGF signaling pathway	P01160	IP3 receptor	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00056	VEGF signaling pathway	P01425	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02770	Pyridoxal phosphate salvage pathway	P03121	Pyridoxal kinase	PANTR|Ensembl=ENSPTRG00000040962|UniProtKB=H2RGH3	Pyridoxal (Pyridoxine, vitamin B6) kinase	ISS	9099727	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P02763	Peptidoglycan biosynthesis	P03092	Phospho-N-acetylmuramoyl pentapeptide transferase	STRCO|EnsemblGenome=CAB51996|UniProtKB=P56833	Phospho-N-acetylmuramoyl-pentapeptide-transferase	ISS			PTHR22926:SF5	PHOSPHO-N-ACETYLMURAMOYL-PENTAPEPTIDE-TRANSFERASE
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	CHICK|Ensembl=ENSGALG00000000681|UniProtKB=E1C3P6	Uncharacterized protein	ISS	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00057	Wnt signaling pathway	P01457	GBeta	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04393	Ras Pathway	P04541	p90RSK	XENTR|Xenbase=XB-GENE-480947|UniProtKB=F6ZM17	Uncharacterized protein (Fragment)	ISS	2779569	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00034	Integrin signalling pathway	P00944	Actin	DANRE|ZFIN=ZDB-GENE-000329-1|UniProtKB=Q7ZVI7	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00006	Apoptosis signaling pathway	P00259	TNF	MACMU|Ensembl=ENSMMUG00000008843|UniProtKB=Q5TM20	Lymphotoxin-alpha	ISS			PTHR11471:SF31	LYMPHOTOXIN-ALPHA
P00047	PDGF signaling pathway	P01149	MNK1/2	MACMU|Ensembl=ENSMMUG00000020162|UniProtKB=F6TJV6	Uncharacterized protein	ISS	Q9BUB5	SPACC	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00005	Angiogenesis	P00220	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	11840290	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01142	p90RSK	RAT|RGD=1307277|UniProtKB=D3ZSB7	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF41	RIBOSOMAL PROTEIN S6 KINASE ALPHA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	HUMAN|HGNC=16810|UniProtKB=P57771	Regulator of G-protein signaling 8	ISS	8756726	PubMed	PTHR10845:SF147	REGULATOR OF G-PROTEIN SIGNALING 8
P00035	Interferon-gamma signaling pathway	P00958	PIAS	HUMAN|HGNC=17002|UniProtKB=Q8N2W9	E3 SUMO-protein ligase PIAS4	TAS	8682149	PubMed	PTHR10782:SF9	E3 SUMO-PROTEIN LIGASE PIAS4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=30035|UniProtKB=Q8WYR1	Phosphoinositide 3-kinase regulatory subunit 5	ISS	129387	gi	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00020	FAS signaling pathway	P00615	JNK	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	TAS	12040174	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	IC	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00021	FGF signaling pathway	P00632	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00564	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00021	FGF signaling pathway	P00646	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	YEAST|SGD=S000005854|UniProtKB=P33328	Synaptobrevin homolog 2	ISS			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00053	T cell activation	P01314	nck	HUMAN|HGNC=7664|UniProtKB=P16333	Cytoplasmic protein NCK1	IPI	11689432	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P00059	p53 pathway	P04630	PP2A	DROME|FlyBase=FBgn0004177|UniProtKB=P23696	Serine/threonine-protein phosphatase PP2A	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CAEEL|WormBase=WBGene00001681|UniProtKB=P54406	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF3	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA-RELATED
P00059	p53 pathway	G04699	BAI-1	MACMU|Ensembl=ENSMMUG00000019877|UniProtKB=F7GRY4	Uncharacterized protein	ISS	9393972	PubMed	PTHR12011:SF39	BRAIN-SPECIFIC ANGIOGENESIS INHIBITOR 1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	ORYSJ|EnsemblGenome=OS03G0661300|UniProtKB=Q76FS2	Tubulin beta-8 chain	ISS	9454836	PubMed	PTHR11588:SF246	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MOUSE|MGI=MGI=1933206|UniProtKB=A2AIR5	Protein Grin3a	ISS	11554554	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00012	Cadherin signaling pathway	P00474	Wnt	DANRE|ZFIN=ZDB-GENE-980526-249|UniProtKB=Q9I9I2	Protein Wnt	IDA	11266476	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P02723	Adenine and hypoxanthine salvage pathway	P02810	Adenine phosphoribosyl transferase	LEIMA|EnsemblGenome=LmjF.26.0140|UniProtKB=Q4Q9H8	Adenine phosphoribosyltransferase	ISS			PTHR11776:SF0	ADENINE PHOSPHORIBOSYLTRANSFERASE-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00057	Wnt signaling pathway	P01430	p53	DANRE|ZFIN=ZDB-GENE-990415-270|UniProtKB=P79734	Cellular tumor antigen p53	IDA	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00006	Apoptosis signaling pathway	P00269	MAPK	ORYSJ|EnsemblGenome=OS02G0148100|UniProtKB=Q6Z437	Mitogen-activated protein kinase 3	ISS	9836510	gi	PTHR24055:SF216	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00193	SOS-1	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00021	FGF signaling pathway	P00640	PI3K	CAEEL|WormBase=WBGene00009552|UniProtKB=G5EDY0	Phosphatidylinositol 3-kinase piki-1	ISS	7937853	PubMed	PTHR10048:SF64	LD28067P
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00046	Oxidative stress response	P01129	JNK1/2	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	ISS	15737619	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	HUMAN|HGNC=18855|UniProtKB=Q68CJ9	Cyclic AMP-responsive element-binding protein 3-like protein 3	ISS	1354612	PubMed	PTHR22952:SF98	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 3
P00010	B cell activation	P00369	MEKK	HUMAN|HGNC=6855|UniProtKB=Q99759	Mitogen-activated protein kinase kinase kinase 3	IDA	8649450	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00013	Cell cycle	P00484	Cyclin D	RAT|RGD=68384|UniProtKB=P39948	G1/S-specific cyclin-D1	ISS	93330551	PubMed	PTHR10177:SF67	G1/S-SPECIFIC CYCLIN-D1
P02743	Formyltetrahydroformate biosynthesis	P02953	Cobalamin dependent homocysteine transmethylase	PANTR|Ensembl=ENSPTRG00000002145|UniProtKB=H2R7Z7	5-methyltetrahydrofolate-homocysteine methyltransferase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00018	EGF receptor signaling pathway	P00556	PLCgamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IGI	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	IDA	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05925	beta-ARR1	MOUSE|MGI=MGI=99473|UniProtKB=Q8BWG8	Beta-arrestin-1	RCA	4757780	gi	PTHR11792:SF22	BETA-ARRESTIN-1
P00001	Adrenaline and noradrenaline biosynthesis	P00063	DBH	MACMU|Ensembl=ENSMMUG00000017207|UniProtKB=F7HGF9	Uncharacterized protein	ISS	90219125	PubMed	PTHR10157:SF29	DOPAMINE BETA-HYDROXYLASE
P00057	Wnt signaling pathway	P01444	Wnt	RAT|RGD=621346|UniProtKB=Q2IBD1	Protein Wnt	IDA	8717036	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	CANLF|Ensembl=ENSCAFG00000028654|UniProtKB=J9P702	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00989	Ets	MOUSE|MGI=MGI=1341168|UniProtKB=Q6P3D7	Transcription factor Spi-C	TAS	8970723	PubMed	PTHR11849:SF17	TRANSCRIPTION FACTOR SPI-C
P00056	VEGF signaling pathway	P01425	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	10395542	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00025	Hedgehog signaling pathway	P00692	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04397	p53 pathway by glucose deprivation	P04641	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00584	Gs	CAEEL|WormBase=WBGene00001745|UniProtKB=Q7KPV0	G protein, Subunit Alpha	ISS	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00021	FGF signaling pathway	P00640	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01230	Src kinase	BOVIN|Ensembl=ENSBTAG00000012695|UniProtKB=Q3ZCM0	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF39	TYROSINE-PROTEIN KINASE LCK
P00048	PI3 kinase pathway	P01202	p85	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00047	PDGF signaling pathway	P01153	GSK3	DICDI|dictyBase=DDB_G0272110|UniProtKB=P51136	Glycogen synthase kinase-3	ISS	7529201	PubMed	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00060	Ubiquitin proteasome pathway	P01491	E2	XENTR|Xenbase=XB-GENE-941508|UniProtKB=F7C462	Uncharacterized protein (Fragment)	ISS			PTHR24068:SF70	UBIQUITIN-CONJUGATING ENZYME E2 E1
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00047	PDGF signaling pathway	P01168	PI3K	ARATH|TAIR=AT1G60490|UniProtKB=P42339	Phosphatidylinositol 3-kinase VPS34	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00018	EGF receptor signaling pathway	P00545	JNK1-3	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS			PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00059	p53 pathway	G04694	p110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01182	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P02766	Phenylethylamine degradation	P03103	Phenylethylamine oxidase	ARATH|TAIR=AT4G12270|UniProtKB=Q9STI4	Amine oxidase	ISS			PTHR10638:SF41	AMINE OXIDASE
P00034	Integrin signalling pathway	P00944	Actin	XENTR|Xenbase=XB-GENE-490883|UniProtKB=Q6NVA9	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00640	PI3K	ANOGA|EnsemblGenome=AGAP011036|UniProtKB=A0NBA9	AGAP011036-PA (Fragment)	ISS	7937853	PubMed	PTHR10048:SF64	LD28067P
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01314	nck	CANLF|Ensembl=ENSCAFG00000007451|UniProtKB=E2RHV6	Uncharacterized protein	ISS	11689432	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P04393	Ras Pathway	P04542	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01471	alpha-catenin	MOUSE|MGI=MGI=88275|UniProtKB=Q61301	Catenin alpha-2	IDA	1638632	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	PANTR|Gene=CHRM3|UniProtKB=Q9N2A4	Muscarinic acetylcholine receptor M3	IDA	12915051	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P06587	Nicotine pharmacodynamics pathway	P06606	ADCY2	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	RCA	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	HUMAN|HGNC=10934|UniProtKB=P54219	Chromaffin granule amine transporter	ISS	92370677	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P02752	Mannose metabolism	P03019	P-Mannose mutase	MOUSE|MGI=MGI=1353418|UniProtKB=O35621	Phosphomannomutase 1	ISS	11042159	PubMed	PTHR10466:SF1	PHOSPHOMANNOMUTASE 1
P00010	B cell activation	P00402	Jnk	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	SCHPO|PomBase=SPBC25D12.04|UniProtKB=P36603	Ribonucleoside-diphosphate reductase small chain	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00029	Huntington disease	P00801	Fos protein	BOVIN|Ensembl=ENSBTAG00000004322|UniProtKB=O77628	Proto-oncogene c-Fos	TAS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00018	EGF receptor signaling pathway	P00562	p38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	CHICK|Ensembl=ENSGALG00000005065|UniProtKB=P49147	Cytosolic phospholipase A2	ISS	94299545	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	MOUSE|MGI=MGI=1930182|UniProtKB=Q9WV85	Nucleoside diphosphate kinase 3	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P00006	Apoptosis signaling pathway	P00318	PKCs	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00914	Filamin	RAT|RGD=1560614|UniProtKB=C0JPT7	Filamin alpha	ISS	11911837	PubMed	PTHR43998:SF6	FILAMIN-A
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	BOVIN|Ensembl=ENSBTAG00000010830|UniProtKB=E1BGJ0	Uncharacterized protein	ISS	11907044	PubMed	PTHR44025:SF2	PROLOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1
P00019	Endothelin signaling pathway	P00572	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IGI	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=1890219|UniProtKB=Q99PF4	Cadherin-23	IDA	8120095	PubMed	PTHR43956:SF3	CADHERIN-23
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	RAT|RGD=2156|UniProtKB=P29066	Beta-arrestin-1	ISS	11742073	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	BOVIN|Ensembl=ENSBTAG00000011429|UniProtKB=Q8SQ19	Cyclic AMP-responsive element-binding protein 3	RCA			PTHR22952:SF100	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3
P04393	Ras Pathway	P04567	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00645	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	DICDI|dictyBase=DDB_G0277221|UniProtKB=P25870	Clathrin heavy chain	IDA	9388255	PubMed	PTHR10292:SF1	CLATHRIN HEAVY CHAIN
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00004	Alzheimer disease-presenilin pathway	P00114	actin	STRPU|EnsemblGenome=SPU_026078|UniProtKB=W4ZD41	Uncharacterized protein	IDA	10974003	PubMed	PTHR11937:SF277	SUBFAMILY NOT NAMED
P02772	Pyruvate metabolism	P03140	Pyruvate Carboxylase	PSEAE|EnsemblGenome=PA1400|UniProtKB=Q9I3U4	Probable pyruvate carboxylase	IEA	10984043	PubMed	PTHR42962:SF1	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00059	p53 pathway	P01486	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	RAT|RGD=1307380|UniProtKB=B2RYJ7	ARP1 actin-related protein 1 homolog B (Yeast)	ISS	14684598	PubMed	PTHR11937:SF195	BETA-CENTRACTIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	RCA	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00369	MEKK	HUMAN|HGNC=6854|UniProtKB=Q9Y2U5	Mitogen-activated protein kinase kinase kinase 2	IDA	8621389	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00021	FGF signaling pathway	P00632	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IGI	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04453	ACTH	PANTR|Ensembl=ENSPTRG00000011721|UniProtKB=H2R8Y3	Uncharacterized protein	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00012	Cadherin signaling pathway	P00470	F-actin	DANRE|ZFIN=ZDB-GENE-050417-267|UniProtKB=F1QUN8	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF263	ACTIN
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=1310389|UniProtKB=D3ZTF6	Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Predicted), isoform CRA_a	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P06212	DPP-SCW signaling pathway	P06275	SCW full length	DROME|FlyBase=FBgn0005590|UniProtKB=P54631	Protein screw	IEA	7958918	PubMed	PTHR11848:SF54	PROTEIN 60A-RELATED
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	ECOLI|EcoGene=EG11002|UniProtKB=P0A884	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	IDA	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00010	B cell activation	P00376	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IDA	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	ISS	8836152	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P02756	N-acetylglucosamine metabolism	P03041	Glucosamine-6-phosphate deaminase	MONDO|Ensembl=ENSMODG00000020593|UniProtKB=F7A0L7	Glucosamine-6-phosphate isomerase	ISS			PTHR11280:SF9	GLUCOSAMINE-6-PHOSPHATE ISOMERASE 2
P02741	Flavin biosynthesis	P02939	Lumazine synthase	GLOVI|EnsemblGenome=BAC88983|UniProtKB=Q7NLS9	6,7-dimethyl-8-ribityllumazine synthase	ISS			PTHR21058:SF0	6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	8170357	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	IC	10514528	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00018	EGF receptor signaling pathway	P00559	MEK1-2	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=98328|UniProtKB=P30875	Somatostatin receptor type 2	ISS	12181435	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P00005	Angiogenesis	P00206	Wnt	BOVIN|Ensembl=ENSBTAG00000015364|UniProtKB=E1BEN9	Protein Wnt	ISS	14644163	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000033526|UniProtKB=E1B8Q3	Guanine nucleotide binding protein 13, gamma-like	ISS	10391901	PubMed	PTHR15936:SF2	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-13
P04393	Ras Pathway	P04572	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00034	Integrin signalling pathway	P00907	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00010	B cell activation	P00386	Calcineurin	MOUSE|MGI=MGI=107163|UniProtKB=P48453	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	IDA	12091710	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04398	p53 pathway feedback loops 2	P04657	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	EMENI|EnsemblGenome=CADANIAG00006296|UniProtKB=Q5ASG1	Putative synaptobrevin homologue SNC1/2 (Eurofung)	ISS			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00010	B cell activation	P00373	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IGI	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00048	PI3 kinase pathway	P01177	P110ACT	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02746	Heme biosynthesis	P02976	Protoporphyrinogen oxidase	BOVIN|Ensembl=ENSBTAG00000021894|UniProtKB=P56602	Protoporphyrinogen oxidase	ISS			PTHR42923:SF3	PROTOPORPHYRINOGEN OXIDASE
P00030	Hypoxia response via HIF activation	P00817	TOR	CANLF|Ensembl=ENSCAFG00000016648|UniProtKB=E2R2L2	Uncharacterized protein	ISS	8662507	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	MOUSE|MGI=MGI=97453|UniProtKB=P35454	Oxytocin-neurophysin 1	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00029	Huntington disease	P00807	Actin	MONBE|Gene=37852|UniProtKB=A9V489	Predicted protein	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05941	GRK3	MOUSE|MGI=MGI=87941|UniProtKB=Q3UYH7	Beta-adrenergic receptor kinase 2	ISS	8288567	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P00047	PDGF signaling pathway	P01156	PDGF receptor B	RAT|RGD=1308028|UniProtKB=Q5RJP7	Platelet-derived growth factor receptor-like protein	ISS			PTHR15360:SF1	PLATELET-DERIVED GROWTH FACTOR RECEPTOR-LIKE PROTEIN
P00019	Endothelin signaling pathway	P00591	PLCbeta	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	TAKRU|Ensembl=ENSTRUG00000008289|UniProtKB=H2T7U8	Uncharacterized protein	ISS	9658176	PubMed	PTHR24072:SF129	CDC42L PROTEIN
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	MACMU|Ensembl=ENSMMUG00000019112|UniProtKB=F6T8S6	N-methyl D-aspartate receptor subtype 2B	ISS	11554554	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00057	Wnt signaling pathway	P01448	CBP	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	ISS	9716402	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00636	FGFR1-4	CHICK|Gene=FGFR3|UniProtKB=P18460	Fibroblast growth factor receptor 3	ISS			PTHR24416:SF505	FIBROBLAST GROWTH FACTOR RECEPTOR 3
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	LEIMA|EnsemblGenome=LmjF.35.3960|UniProtKB=E9AFM1	Protein kinase A catalytic subunit isoform 2	IC	10218114	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	BOVIN|Ensembl=ENSBTAG00000010386|UniProtKB=Q3MHR7	Actin-related protein 2/3 complex subunit 2	TAS	12473693	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PANTR|Ensembl=ENSPTRG00000012624|UniProtKB=H2QZG8	Uncharacterized protein	ISS	22028976	PubMed	PTHR13140:SF311	MYOSIN-IIIB
P00047	PDGF signaling pathway	P01164	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05917	Opioid proopiomelanocortin pathway	P06006	beta-Endorphin	RAT|RGD=3366|UniProtKB=P01194	Pro-opiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02723	Adenine and hypoxanthine salvage pathway	P02810	Adenine phosphoribosyl transferase	ARATH|TAIR=AT4G22570|UniProtKB=Q9SUW2	Adenine phosphoribosyltransferase 3	ISS			PTHR11776:SF7	ADENINE PHOSPHORIBOSYLTRANSFERASE 3-RELATED
P00006	Apoptosis signaling pathway	P00274	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	HUMAN|HGNC=144|UniProtKB=P63261	Actin, cytoplasmic 2	IC	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DANRE|ZFIN=ZDB-GENE-040426-1354|UniProtKB=Q7T2C5	Protein kinase C	ISS	11880265	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	TAS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00056	VEGF signaling pathway	P01413	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00058	mRNA splicing	P01473	U6	PANTR|Ensembl=ENSPTRG00000001254|UniProtKB=G2HGL9	PRP3 pre-mRNA processing factor 3 homolog	ISS	12875835	PubMed	PTHR14212:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	TAKRU|Ensembl=ENSTRUG00000007989|UniProtKB=P68140	Actin, alpha skeletal muscle A	IDA	11889126	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00029	Huntington disease	P00810	GAPDH	EMENI|EnsemblGenome=CADANIAG00004062|UniProtKB=P20445	Glyceraldehyde-3-phosphate dehydrogenase	ISS			PTHR10836:SF52	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED
P00059	p53 pathway	P04630	PP2A	MACMU|Ensembl=ENSMMUG00000013047|UniProtKB=F7H808	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P02783	Tryptophan biosynthesis	P03208	Tryptophan synthase B	HALSA|EnsemblGenome=VNG_0307G|UniProtKB=Q9HSC0	Tryptophan synthase beta chain	ISS			PTHR42882:SF1	TRYPTOPHAN SYNTHASE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CHICK|Ensembl=ENSGALG00000026802|UniProtKB=G1K338	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	HUMAN|HGNC=9508|UniProtKB=P49768	Presenilin-1	IDA	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MACMU|Ensembl=ENSMMUG00000030028|UniProtKB=F7H0X2	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00819	AKT	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	TAS	14526383	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01312	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00036	Interleukin signaling pathway	P00983	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00019	Endothelin signaling pathway	P00589	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00769	N-Wasp	CANLF|Ensembl=ENSCAFG00000001771|UniProtKB=E2RCG1	Uncharacterized protein	ISS	12932731	PubMed	PTHR23202:SF39	NEURAL WISKOTT-ALDRICH SYNDROME PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00057	Wnt signaling pathway	P01448	CBP	ARATH|TAIR=AT1G16710|UniProtKB=Q9FWQ5	Histone acetyltransferase HAC12	ISS	8413673	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00046	Oxidative stress response	P01131	MKP5	DROME|FlyBase=FBgn0243512|UniProtKB=Q9VHV8	Puckered, isoform A	ISS			PTHR10159:SF390	PUCKERED, ISOFORM A
P00034	Integrin signalling pathway	P00912	Arp2/3	ORNAN|Ensembl=ENSOANG00000007724|UniProtKB=F6QTB5	Uncharacterized protein	ISS	12932731	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P02788	Xanthine and guanine salvage pathway	P03247	Xanthine phosphoribosyl transferase	TAKRU|Ensembl=ENSTRUG00000003211|UniProtKB=H2S550	Uncharacterized protein	ISS			PTHR43340:SF6	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P02724	Alanine biosynthesis	P02815	Branched chain amino acid aminotransferase	MACMU|Ensembl=ENSMMUG00000010079|UniProtKB=F6ZG15	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF39	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, MITOCHONDRIAL
P00060	Ubiquitin proteasome pathway	P01490	E3	ORNAN|Ensembl=ENSOANG00000007719|UniProtKB=F6TJ28	Uncharacterized protein (Fragment)	ISS	11252892	PubMed	PTHR11254:SF293	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P00019	Endothelin signaling pathway	P00577	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IGI	10799299	PubMed	PTHR10048:SF14	PI-3 KINASE
P00021	FGF signaling pathway	P00624	14-3-3	PANTR|Ensembl=ENSPTRG00000019320|UniProtKB=H2QUT2	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	ISS	99360936	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000008368|UniProtKB=F7CX62	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF61	PROTOCADHERIN BETA-13
P00023	General transcription regulation	P00660	RNA Polymerase II	BOVIN|Ensembl=ENSBTAG00000001856|UniProtKB=Q3T0Q3	DNA-directed RNA polymerase II subunit RPB3	ISS	2187864	PubMed	PTHR11800:SF2	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CAEEL|WormBase=WBGene00002038|UniProtKB=G5ECZ0	Heavy chain, Unconventional Myosin	IC			PTHR13140:SF713	MYOSIN-IA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	PANTR|Ensembl=ENSPTRG00000000323|UniProtKB=H2PYA3	Uncharacterized protein	ISS			PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00053	T cell activation	P01336	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IGI	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00807	Actin	CRYNJ|EnsemblGenome=CNA04650|UniProtKB=Q5KP06	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	91232861	PubMed	PTHR24070:SF385	GTPASE HRAS
P02783	Tryptophan biosynthesis	P03208	Tryptophan synthase B	AQUAE|EnsemblGenome=aq_706|UniProtKB=O66923	Tryptophan synthase beta chain 1	ISS			PTHR42882:SF1	TRYPTOPHAN SYNTHASE
P00029	Huntington disease	P00766	Htt	MOUSE|MGI=MGI=96067|UniProtKB=P42859	Huntingtin	IDA	8268927	PubMed	PTHR10170:SF10	HUNTINGTIN
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00584	Gs	MONDO|Ensembl=ENSMODG00000021434|UniProtKB=F7CB49	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00010	B cell activation	P00371	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00045	Notch signaling pathway	P01114	Ntm	HUMAN|HGNC=7884|UniProtKB=Q99466	Neurogenic locus notch homolog protein 4	ISS	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P00054	Toll receptor signaling pathway	P01345	IKKalpha	RAT|RGD=1306661|UniProtKB=G3V926	Conserved helix-loop-helix ubiquitous kinase (Predicted)	ISS	12235208	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P05913	Enkephalin release	P05972	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00011	Blood coagulation	P00443	Fibrin polymer cross-linked	XENTR|Xenbase=XB-GENE-483216|UniProtKB=B0JZ09	Fgb protein	ISS	1160337	gi	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00019	Endothelin signaling pathway	P00591	PLCbeta	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IGI	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00036	Interleukin signaling pathway	P00996	STAT	CHICK|Ensembl=ENSGALG00000003267|UniProtKB=Q6DV79	Signal transducer and activator of transcription 3	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00057	Wnt signaling pathway	P01430	p53	RAT|RGD=3889|UniProtKB=P10361	Cellular tumor antigen p53	IDA	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04586	ProTRH (Pro Thyrotropin-releasing Hormone)	HUMAN|HGNC=1885|UniProtKB=P01215	Glycoprotein hormones alpha chain	ISS			PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IGI	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04552	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05731	GABA-B receptor II signaling	P05752	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	8787761	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	10755300	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00059	p53 pathway	P01486	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	RAT|RGD=621060|UniProtKB=O88777	Presenilin-2	IDA	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IDA	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00778	NMDA receptor	RAT|RGD=621705|UniProtKB=Q8VHN2	Glutamate receptor ionotropic, NMDA 3B	IDA	14698601	PubMed	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P00036	Interleukin signaling pathway	P00974	Receptor subunit beta	HUMAN|HGNC=5972|UniProtKB=Q99665	Interleukin-12 receptor subunit beta-2	IC	8943050	PubMed	PTHR23036:SF79	INTERLEUKIN-12 RECEPTOR SUBUNIT BETA-2
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	MOUSE|MGI=MGI=106217|UniProtKB=Q61290	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	14624853	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IDA	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MOUSE|MGI=MGI=88396|UniProtKB=P12657	Muscarinic acetylcholine receptor M1	TAS	12915051	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12805548	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	BOVIN|Ensembl=ENSBTAG00000033153|UniProtKB=F1MG21	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05730	Endogenous cannabinoid signaling	P05746	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IC	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00011	Blood coagulation	P00440	ATIII	TAKRU|Ensembl=ENSTRUG00000010570|UniProtKB=H2TPS0	Uncharacterized protein	ISS	4774082	gi	PTHR11461:SF53	ANTITHROMBIN-III
P00052	TGF-beta signaling pathway	P01286	TGFbeta	PANTR|Ensembl=ENSPTRG00000004615|UniProtKB=H2Q5C7	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF38	GROWTH/DIFFERENTIATION FACTOR 3
P00049	Parkinson disease	P01242	Casein kinase I	YEAST|SGD=S000005098|UniProtKB=P23292	Casein kinase I homolog 2	IDA	10617630	PubMed	PTHR11909:SF117	CASEIN KINASE I HOMOLOG 1-RELATED
P00034	Integrin signalling pathway	P00907	ERK	CHICK|Ensembl=ENSGALG00000004690|UniProtKB=Q5F3W3	Mitogen-activated protein kinase 6	ISS	8444355	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	XENTR|Xenbase=XB-GENE-481916|UniProtKB=F6YF14	Presenilin	ISS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	IDA	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05913	Enkephalin release	P05972	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	IC	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05913	Enkephalin release	P05974	G-Protein (i)	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P06959	CCKR signaling map	P07166	MAPK1	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	RCA	12488236	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00983	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04393	Ras Pathway	P04557	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01177	P110ACT	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05915	Opioid proenkephalin pathway	P05994	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00805	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	BOVIN|Ensembl=ENSBTAG00000014299|UniProtKB=Q1RMJ6	Rho-related GTP-binding protein RhoC	ISS	14871999	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01437	TCF	HUMAN|HGNC=11641|UniProtKB=Q9NQB0	Transcription factor 7-like 2	IDA	12176738	PubMed	PTHR10373:SF32	TRANSCRIPTION FACTOR 7-LIKE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IC	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IDA	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00006	Apoptosis signaling pathway	P00291	MEKK1	HUMAN|HGNC=6848|UniProtKB=Q13233	Mitogen-activated protein kinase kinase kinase 1	RCA			PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	HUMAN|HGNC=23366|UniProtKB=Q9BPX5	Actin-related protein 2/3 complex subunit 5-like protein	ISS	12932731	PubMed	PTHR12644:SF2	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5-LIKE PROTEIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000005691|UniProtKB=F6U596	Uncharacterized protein	ISS			PTHR24248:SF17	ALPHA-1B ADRENERGIC RECEPTOR
P00012	Cadherin signaling pathway	P00476	Yes	BOVIN|Ensembl=ENSBTAG00000001523|UniProtKB=A7MB57	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF90	TYROSINE-PROTEIN KINASE YES
P00060	Ubiquitin proteasome pathway	P01492	E1	CANLF|Ensembl=ENSCAFG00000002765|UniProtKB=E2R529	Uncharacterized protein	ISS			PTHR10953:SF186	UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 6
P00010	B cell activation	P00388	PLC gamma2	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IGI	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	RCA	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00048	PI3 kinase pathway	P01185	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00036	Interleukin signaling pathway	P00965	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9836512	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00644	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04393	Ras Pathway	P04565	MKK4/7	HUMAN|HGNC=6847|UniProtKB=O14733	Dual specificity mitogen-activated protein kinase kinase 7	ISS	15039780	PubMed	PTHR24361:SF387	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	DICDI|dictyBase=DDB_G0279413|UniProtKB=P05987	cAMP-dependent protein kinase regulatory subunit	ISS	176910	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00093	Tip60	MOUSE|MGI=MGI=1261791|UniProtKB=P98084	Amyloid beta A4 precursor protein-binding family A member 2	IC			PTHR12345:SF12	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ASHGO|EnsemblGenome=AGOS_ABR222W|UniProtKB=Q75D00	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00054	Toll receptor signaling pathway	P01341	Elk1	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	ISS	12660819	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P04393	Ras Pathway	P04574	PLD	HUMAN|HGNC=9067|UniProtKB=Q13393	Phospholipase D1	IDA	10497874	PubMed	PTHR18896:SF57	PHOSPHOLIPASE D1
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	MOUSE|MGI=MGI=1321159|UniProtKB=P63330	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	10644715	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00053	T cell activation	P01336	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02738	De novo purine biosynthesis	P02905	Amidophosphoribosyl transferase	METAC|EnsemblGenome=MA_3193|UniProtKB=Q8TL49	Amidophosphoribosyltransferase	ISS			PTHR11907:SF0	AMIDOPHOSPHORIBOSYLTRANSFERASE
P00007	Axon guidance mediated by semaphorins	P00340	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	CANLF|Ensembl=ENSCAFG00000019435|UniProtKB=E2QX25	Uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF157	CASEIN KINASE I ISOFORM GAMMA-2
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	TAS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00054	Toll receptor signaling pathway	P01371	TRAF6	MACMU|Gene=TRAF6|UniProtKB=B6CJY5	TNF receptor-associated factor 6	ISS			PTHR10131:SF111	TNF RECEPTOR-ASSOCIATED FACTOR 6
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00029	Huntington disease	P00778	NMDA receptor	MOUSE|MGI=MGI=1933206|UniProtKB=A2AIR5	Protein Grin3a	ISS	11319238	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02738	De novo purine biosynthesis	P02908	Phosphoribosylamine glycine ligase	SYNY3|EnsemblGenome=BAA18326|UniProtKB=P74232	Phosphoribosylamine--glycine ligase	ISS			PTHR43472:SF1	PHOSPHORIBOSYLAMINE--GLYCINE LIGASE
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	MOUSE|MGI=MGI=1338944|UniProtKB=Q61271	Activin receptor type-1B	TAS	10683140	PubMed	PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	PSEAE|EnsemblGenome=PA4758|UniProtKB=P38098	Carbamoyl-phosphate synthase small chain	ISS			PTHR11405:SF4	CARBAMOYL-PHOSPHATE SYNTHASE ARGININE-SPECIFIC SMALL CHAIN
P05913	Enkephalin release	P05974	G-Protein (i)	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00056	VEGF signaling pathway	P01409	cPLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00045	Notch signaling pathway	P01107	Fringe	RAT|RGD=735126|UniProtKB=G3V725	Manic fringe homolog (Drosophila)	ISS	9187150	PubMed	PTHR10811:SF6	BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE MANIC FRINGE
P00005	Angiogenesis	P00223	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	IC	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00010	B cell activation	P00381	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Gene=DRD2|UniProtKB=P60026	D(2) dopamine receptor	ISS	2039532	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	BOVIN|Ensembl=ENSBTAG00000019337|UniProtKB=F1MMW7	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF58	ACTIVIN RECEPTOR TYPE-1C
P00034	Integrin signalling pathway	P00928	alpha actinin	CHICK|Gene=ACTN2|UniProtKB=P20111	Alpha-actinin-2	ISS	2116421	PubMed	PTHR43947:SF4	ALPHA-ACTININ-2
P00049	Parkinson disease	P01219	SAPK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ARATH|TAIR=AT3G46520|UniProtKB=P53497	Actin-12	IC	14684598	PubMed	PTHR11937:SF276	ACTIN-12
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00747	Rhodopsin	CANLF|Gene=RHO|UniProtKB=P32308	Rhodopsin	ISS	1634520	PubMed	PTHR24240:SF15	RHODOPSIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00029	Huntington disease	P00807	Actin	CAEBR|Gene=CBG02161|UniProtKB=A8WS32	Protein CBG02161	ISS	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00050	Plasminogen activating cascade	P01246	Plasmin	MOUSE|MGI=MGI=97620|UniProtKB=P20918	Plasminogen	ISS	16758216	gi	PTHR24261:SF5	PLASMINOGEN
P00037	Ionotropic glutamate receptor pathway	P01026	KA	HUMAN|HGNC=4579|UniProtKB=P39086	Glutamate receptor ionotropic, kainate 1	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00029	Huntington disease	P00807	Actin	DROME|FlyBase=FBgn0000042|UniProtKB=P10987	Actin-5C	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	DANRE|ZFIN=ZDB-GENE-040801-146|UniProtKB=F1QJL5	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF299	SUBFAMILY NOT NAMED
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	DEIRA|EnsemblGenome=DR_2632|UniProtKB=Q9RR65	Dihydrofolate reductase	ISS			PTHR22778:SF16	DIHYDROFOLATE REDUCTASE
P00057	Wnt signaling pathway	P01471	alpha-catenin	HUMAN|HGNC=2509|UniProtKB=P35221	Catenin alpha-1	IDA	10456847	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00021	FGF signaling pathway	P00633	Ras	CRYNJ|EnsemblGenome=CNA02810|UniProtKB=P0CQ42	Ras-like protein	NAS	7997267	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000008826|UniProtKB=F6XUU0	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00931	Integrin beta	BOVIN|Ensembl=ENSBTAG00000009987|UniProtKB=F1MTN1	Integrin beta	ISS	484963	gi	PTHR10082:SF25	INTEGRIN BETA-3
P06959	CCKR signaling map	P07060	PPARgamma	HUMAN|HGNC=9236|UniProtKB=P37231	Peroxisome proliferator-activated receptor gamma	RCA	16574647	PubMed	PTHR24082:SF14	PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	10218114	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04393	Ras Pathway	P04578	Rho	MONDO|Ensembl=ENSMODG00000012981|UniProtKB=F7CS91	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00049	Parkinson disease	P01234	GRK	RAT|RGD=2062|UniProtKB=P26817	Beta-adrenergic receptor kinase 1	IDA	10852916	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P02772	Pyruvate metabolism	P03132	Pyruvate Kinase	PANTR|Ensembl=ENSPTRG00000001421|UniProtKB=H2RBP4	Pyruvate kinase	RCA			PTHR11817:SF31	PYRUVATE KINASE PKLR
P00034	Integrin signalling pathway	P00944	Actin	ORNAN|Ensembl=ENSOANG00000007716|UniProtKB=F6UDX9	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00018	EGF receptor signaling pathway	P00541	Spry	CANLF|Ensembl=ENSCAFG00000005260|UniProtKB=E2RGU9	Uncharacterized protein	ISS	12402043	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P00057	Wnt signaling pathway	P01437	TCF	PANTR|Ensembl=ENSPTRG00000016352|UniProtKB=H2QQ05	Uncharacterized protein	ISS	9039917	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	ANOGA|EnsemblGenome=AGAP004476|UniProtKB=Q7QA16	AGAP004476-PA	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00048	PI3 kinase pathway	P01205	NOS	RAT|RGD=3185|UniProtKB=Q06518	Nitric oxide synthase, inducible	IDA	11846418	PubMed	PTHR19384:SF56	NITRIC OXIDE SYNTHASE, INDUCIBLE
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000017387|UniProtKB=E2RLD1	Uncharacterized protein	ISS	129387	gi	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	IDA	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05912	Dopamine receptor mediated signaling pathway	P05963	MAO	PANTR|Ensembl=ENSPTRG00000021817|UniProtKB=H2QYH6	Amine oxidase [flavin-containing]	ISS	90344230	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P04398	p53 pathway feedback loops 2	P04651	Ras	DANRE|ZFIN=ZDB-GENE-040426-740|UniProtKB=Q7ZUL8	Uncharacterized protein	ISS	10825661	PubMed	PTHR24070:SF381	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	ISS	3487386	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CAEEL|WormBase=WBGene00006454|UniProtKB=G5EEN8	AEX-4	ISS			PTHR19305:SF10	AEX-4
P00006	Apoptosis signaling pathway	P00269	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	HUMAN|HGNC=4583|UniProtKB=Q16478	Glutamate receptor ionotropic, kainate 5	ISS	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00034	Integrin signalling pathway	P00916	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IPI	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00053	T cell activation	P01320	PLC-gamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	PANTR|Ensembl=ENSPTRG00000014418|UniProtKB=H2QLS0	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	DICDI|dictyBase=DDB_G0280039|UniProtKB=P22467	Myosin IA heavy chain	IC			PTHR13140:SF655	MYOSIN IA HEAVY CHAIN
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	RAT|RGD=2521|UniProtKB=P19020	D(3) dopamine receptor	ISS	1319557	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00059	p53 pathway	P04616	PDK1/2	YEAST|SGD=S000002898|UniProtKB=Q03407	Serine/threonine-protein kinase PKH1	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00010	B cell activation	P00388	PLC gamma2	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P06210	Activin beta signaling pathway	P06239	DAD	DROME|FlyBase=FBgn0020493|UniProtKB=Q5U110	Mothers against decapentaplegic homolog	IEA	http://flybase.org/reports/FBgn0020493.html	Website	PTHR13703:SF44	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	SCHPO|PomBase=SPBC32H8.07|UniProtKB=Q10282	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000005792|UniProtKB=F6VTR8	Uncharacterized protein	ISS	12507995	PubMed	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00056	VEGF signaling pathway	P01422	eNOS	PANTR|Ensembl=ENSPTRG00000019868|UniProtKB=H2QVM2	Nitric oxide synthase	ISS	9837777	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	IDA	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00034	Integrin signalling pathway	P00916	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	3035212	PubMed	PTHR24070:SF385	GTPASE HRAS
P00021	FGF signaling pathway	P00636	FGFR1-4	MOUSE|MGI=MGI=95525|UniProtKB=Q03142	Fibroblast growth factor receptor 4	IEP	12466116	PubMed	PTHR24416:SF343	FIBROBLAST GROWTH FACTOR RECEPTOR 4
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00565	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IGI	10747026	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00029	Huntington disease	P00807	Actin	DANRE|ZFIN=ZDB-GENE-030131-1229|UniProtKB=Q6DHS1	Actin, alpha 2, smooth muscle, aorta	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00059	p53 pathway	P01486	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P02746	Heme biosynthesis	P02981	Glutamate-1-semialdehyde aminotransferase	CHLRE|EnsemblGenome=CHLREDRAFT_138524|UniProtKB=A8J7H3	Glutamate-1-semialdehyde aminotransferase	ISS			PTHR43713:SF2	GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE 1, CHLOROPLASTIC-RELATED
P00034	Integrin signalling pathway	P00951	Jnk	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00010	B cell activation	P00398	IP3R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	IGI	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00018	EGF receptor signaling pathway	P00552	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00005	Angiogenesis	P00243	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00007	Axon guidance mediated by semaphorins	P00340	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12960248	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00005	Angiogenesis	P00182	p38MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00807	Actin	CANLF|Ensembl=ENSCAFG00000008756|UniProtKB=F2Z4N8	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PHYPA|Gene=PHYPADRAFT_226658|UniProtKB=A9TYG3	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00558	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00018	EGF receptor signaling pathway	P00565	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IGI	15572354	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00005	Angiogenesis	P00219	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00029	Huntington disease	P00779	TBP	THEKO|EnsemblGenome=TK0132|UniProtKB=Q52366	TATA-box-binding protein	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00048	PI3 kinase pathway	P01188	Gbetagamma	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	CANLF|Ensembl=ENSCAFG00000018704|UniProtKB=Q9N280	Na+-dependent glutamate transporter	IC	94365697	PubMed	PTHR11958:SF24	EXCITATORY AMINO ACID TRANSPORTER 1
P00010	B cell activation	P00385	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Ensembl=ENSCAFG00000001738|UniProtKB=E2RDG9	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	SULSO|EnsemblGenome=SSO0230|UniProtKB=Q980Q7	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00021	FGF signaling pathway	P00644	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IGI	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=3346|UniProtKB=P10688	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	7822322	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	YEAST|SGD=S000000972|UniProtKB=P26364	GTP:AMP phosphotransferase, mitochondrial	ISS			PTHR23359:SF22	GTP:AMP PHOSPHOTRANSFERASE, MITOCHONDRIAL
P06959	CCKR signaling map	P07180	CAS	HUMAN|HGNC=971|UniProtKB=P56945	Breast cancer anti-estrogen resistance protein 1	RCA	14667936	PubMed	PTHR10654:SF15	BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00059	p53 pathway	G04702	p53	BOVIN|Ensembl=ENSBTAG00000001069|UniProtKB=P67939	Cellular tumor antigen p53	TAS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00052	TGF-beta signaling pathway	P01286	TGFbeta	BOVIN|Ensembl=ENSBTAG00000005111|UniProtKB=A5PJI9	BMP2 protein	ISS	9759503	PubMed	PTHR11848:SF143	BONE MORPHOGENETIC PROTEIN 2
P00005	Angiogenesis	P00185	JAK1	CANLF|Ensembl=ENSCAFG00000018615|UniProtKB=F1PIY7	Tyrosine-protein kinase	ISS	11929133	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CHICK|Ensembl=ENSGALG00000006638|UniProtKB=R4GGL9	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00049	Parkinson disease	P01211	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	97102671	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	88241036	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CANLF|Gene=GRIN1|UniProtKB=Q5R1P0	Glutamate receptor ionotropic, NMDA 1	IC	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P02748	Isoleucine biosynthesis	P02994	Branched chain amino acid aminotransferase	YEAST|SGD=S000003909|UniProtKB=P47176	Branched-chain-amino-acid aminotransferase, cytosolic	ISS			PTHR11825:SF44	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00029	Huntington disease	P00811	Arp2/3 complex	MONDO|Ensembl=ENSMODG00000019755|UniProtKB=F6WN64	Actin-related protein 2/3 complex subunit 5	ISS	12473693	PubMed	PTHR12644:SF2	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5-LIKE PROTEIN
P00053	T cell activation	P01309	fos	PANTR|Ensembl=ENSPTRG00000006553|UniProtKB=A5A6H0	C-fos	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00038	JAK/STAT signaling pathway	P01027	STAT	BOVIN|Ensembl=ENSBTAG00000006335|UniProtKB=F1MGJ4	Signal transducer and activator of transcription	ISS	94367369	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00005	Angiogenesis	P00206	Wnt	BOVIN|Ensembl=ENSBTAG00000001668|UniProtKB=F1N6L8	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00005	Angiogenesis	P00226	Delta/Serrate	MOUSE|MGI=MGI=1859388|UniProtKB=Q9JI71	Delta-like protein 4	ISS	11798067	PubMed	PTHR24044:SF320	DELTA-LIKE PROTEIN 4
P00049	Parkinson disease	P01212	p38 MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	NAS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	IDA	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	MACMU|Ensembl=ENSMMUG00000000304|UniProtKB=F6YVE7	Suppressor of cytokine signaling 4	ISS	15032587	PubMed	PTHR44282:SF2	SUPPRESSOR OF CYTOKINE SIGNALING 4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01179	PKB	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P02728	Arginine biosynthesis	P02847	N-actetylornithine deacetylase	NEUCR|EnsemblGenome=EFNCRG00000003022|UniProtKB=Q7S4G6	Acetylornithine deacetylase	ISS			PTHR43808:SF12	SUBFAMILY NOT NAMED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00023	General transcription regulation	P00668	TFIIB	THEKO|EnsemblGenome=TK2287|UniProtKB=P58109	Transcription initiation factor IIB 2	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CHICK|Ensembl=ENSGALG00000013785|UniProtKB=E1BS74	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IGI	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00053	T cell activation	P01315	Calcineurin	MACMU|Ensembl=ENSMMUG00000004599|UniProtKB=F6Q932	Serine/threonine-protein phosphatase	ISS	7532676	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DANRE|ZFIN=ZDB-GENE-040718-93|UniProtKB=Q6DGZ5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00019	Endothelin signaling pathway	P00591	PLCbeta	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04393	Ras Pathway	P04570	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	7925653	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00055	Transcription regulation by bZIP transcription factor	P01395	TFIIE	CANLF|Ensembl=ENSCAFG00000011306|UniProtKB=E2R3P2	Uncharacterized protein	ISS	189964	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00034	Integrin signalling pathway	P00912	Arp2/3	BOVIN|Ensembl=ENSBTAG00000010386|UniProtKB=Q3MHR7	Actin-related protein 2/3 complex subunit 2	IPI	10940259	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00060	Ubiquitin proteasome pathway	P01494	19S proteasome	CANLF|Ensembl=ENSCAFG00000005398|UniProtKB=E2RH48	Uncharacterized protein	ISS			PTHR23073:SF8	26S PROTEASE REGULATORY SUBUNIT 6B
P00018	EGF receptor signaling pathway	P00547	PP2A	MACMU|Ensembl=ENSMMUG00000013047|UniProtKB=F7H808	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P02763	Peptidoglycan biosynthesis	P03092	Phospho-N-acetylmuramoyl pentapeptide transferase	FUSNN|EnsemblGenome=FN1459|UniProtKB=Q8RDQ0	Phospho-N-acetylmuramoyl-pentapeptide-transferase	ISS			PTHR22926:SF5	PHOSPHO-N-ACETYLMURAMOYL-PENTAPEPTIDE-TRANSFERASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00566	ERK	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	ISS	6319455	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00014	Cholesterol biosynthesis	P00491	Hydroxymethyl glutaryl CoA reductase	MACMU|Ensembl=ENSMMUG00000006139|UniProtKB=F6PRW7	3-hydroxy-3-methylglutaryl coenzyme A reductase	ISS	P09610	SPACC	PTHR10572:SF2	3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	BOVIN|Ensembl=ENSBTAG00000005326|UniProtKB=P67827	Casein kinase I isoform alpha	ISS	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Ensembl=ENSBTAG00000013202|UniProtKB=Q1RML2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1	ISS	12860966	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MONDO|Ensembl=ENSMODG00000018065|UniProtKB=F7G485	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00053	T cell activation	P01331	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IDA	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00036	Interleukin signaling pathway	P00976	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01093	AChE	CHICK|Ensembl=ENSGALG00000009478|UniProtKB=F1NV99	Carboxylic ester hydrolase	IC			PTHR43918:SF5	CHOLINESTERASE
P04393	Ras Pathway	P04567	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00177	Nectin 1alpha C-terminal fragment	MOUSE|MGI=MGI=1926483|UniProtKB=Q9JKF6	Nectin-1	IDA	12376527	PubMed	PTHR23277:SF69	NECTIN-1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02913	Thymidylate synthase	MYCTU|EnsemblGenome=Rv2764c|UniProtKB=P9WFR9	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	BOVIN|Gene=ARRB2|UniProtKB=P32120	Beta-arrestin-2	ISS	4757780	gi	PTHR11792:SF20	BETA-ARRESTIN-2
P05913	Enkephalin release	P05973	GPCR (i)	MACMU|Ensembl=ENSMMUG00000009389|UniProtKB=F7HEV7	Uncharacterized protein	ISS	12093103	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01173	STAT	CHICK|Ensembl=ENSGALG00000003267|UniProtKB=Q6DV79	Signal transducer and activator of transcription 3	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MOUSE|MGI=MGI=894644|UniProtKB=Q8CC27	Voltage-dependent L-type calcium channel subunit beta-2	ISS	20088160	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00057	Wnt signaling pathway	P01457	GBeta	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000016755|UniProtKB=H2QQP6	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF96	CADHERIN-12
P00034	Integrin signalling pathway	P00938	Cdc42	HUMAN|HGNC=1736|UniProtKB=P60953	Cell division control protein 42 homolog	IDA	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00057	Wnt signaling pathway	P01465	Ggamma	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00034	Integrin signalling pathway	P00941	Integrin alpha	MOUSE|MGI=MGI=96603|UniProtKB=Q00651	Integrin alpha-4	IPI	3487386	PubMed	PTHR23220:SF78	INTEGRIN ALPHA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01458	Protein Kinase C	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	10395542	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00049	Parkinson disease	P01227	20S proteasome	MACMU|Ensembl=ENSMMUG00000012363|UniProtKB=F7EIY0	Proteasome subunit beta type	ISS	12859888	PubMed	PTHR11599:SF62	PROTEASOME SUBUNIT BETA TYPE-3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	BOVIN|Ensembl=ENSBTAG00000020756|UniProtKB=A6QLB8	GSK3A protein	ISS	14698990	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	PANTR|Ensembl=ENSPTRG00000004718|UniProtKB=H2Q5I0	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04395	Vasopressin synthesis	P04590	Vasopressin	DANRE|ZFIN=ZDB-GENE-030407-2|UniProtKB=F8W5D0	Uncharacterized protein (Fragment)	ISS			PTHR11681:SF13	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01171	PLCgamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00005	Angiogenesis	P00240	FRS-2	RAT|RGD=1308201|UniProtKB=A0A0G2JZZ5	Protein Frs2	ISS	10464310	PubMed	PTHR21258:SF40	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	RAT|RGD=69346|UniProtKB=G3V7U3	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00047	PDGF signaling pathway	P01162	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00029	Huntington disease	P00779	TBP	CAEBR|Gene=CBG09138|UniProtKB=A8X861	Protein CBR-TBP-1	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	BOVIN|Ensembl=ENSBTAG00000011757|UniProtKB=Q9XT97	Presenilin-1	TAS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00805	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	RAT|RGD=2517|UniProtKB=P47942	Dihydropyrimidinase-related protein 2	TAS	Q90635	SPACC	PTHR11647:SF56	DIHYDROPYRIMIDINASE-RELATED PROTEIN 2
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	METAC|EnsemblGenome=MA_4118|UniProtKB=Q8TIM8	Adenylosuccinate synthetase 2	IEP	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02762	Pentose phosphate pathway	P03070	Gluconate Dehydrogenase	MOUSE|MGI=MGI=97553|UniProtKB=Q9DCD0	6-phosphogluconate dehydrogenase, decarboxylating	ISS	8978909	PubMed	PTHR11811:SF25	6-PHOSPHOGLUCONATE DEHYDROGENASE, DECARBOXYLATING
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P06587	Nicotine pharmacodynamics pathway	P06601	FLNA	MOUSE|MGI=MGI=95556|UniProtKB=Q8BTM8	Filamin-A	RCA	9722563	PubMed	PTHR43998:SF6	FILAMIN-A
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00047	PDGF signaling pathway	P01142	p90RSK	CAEEL|WormBase=WBGene00011352|UniProtKB=Q21734	Putative ribosomal protein S6 kinase alpha-1	ISS	6755374	gi	PTHR24351:SF110	RIBOSOMAL PROTEIN S6 KINASE II, ISOFORM A
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MACMU|Ensembl=ENSMMUG00000012387|UniProtKB=F7EB20	Uncharacterized protein	ISS	8643568	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	G01511	SPRY	PANTR|Ensembl=ENSPTRG00000017360|UniProtKB=H2QRP3	Uncharacterized protein	ISS	10330503	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P06959	CCKR signaling map	P07227	KLF4	HUMAN|HGNC=6348|UniProtKB=O43474	Krueppel-like factor 4	RCA	12372397	PubMed	PTHR44778:SF1	KRUEPPEL-LIKE FACTOR 4
P00005	Angiogenesis	P00246	Ang-2	BOVIN|Ensembl=ENSBTAG00000011034|UniProtKB=O77802	Angiopoietin-2	ISS	9204896	PubMed	PTHR19143:SF199	ANGIOPOIETIN-2
P00012	Cadherin signaling pathway	P00467	alpha-catenin	RAT|RGD=1359485|UniProtKB=Q5U302	Catenin (Cadherin associated protein), alpha 1	ISS	1768802	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P05918	p38 MAPK pathway	P06021	Rac	CHICK|Ensembl=ENSGALG00000012456|UniProtKB=Q5F337	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	TRYB2|Gene=Tb09.211.0350|UniProtKB=Q38EC4	Adenylate kinase, putative	ISS			PTHR23359:SF107	UMP-CMP KINASE
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00371	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-977853|UniProtKB=F7EBE7	Uncharacterized protein	ISS	10051575	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00053	T cell activation	P01332	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IDA	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00205	GAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00006	Apoptosis signaling pathway	P00260	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00470	F-actin	DANRE|ZFIN=ZDB-GENE-040625-35|UniProtKB=Q6IQL9	Novel actin protein	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P02736	Coenzyme A biosynthesis	P02882	Pantothenate cysteine ligase	DEIRA|EnsemblGenome=DR_0579|UniProtKB=Q9RWT6	DNA/pantothenate metabolism flavoprotein	ISS			PTHR14359:SF6	PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE
P00021	FGF signaling pathway	P00648	PKC	SCHPO|PomBase=SPAC17G8.14c|UniProtKB=P36582	Protein kinase C-like 1	IGI	93259141	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MACMU|Ensembl=ENSMMUG00000001661|UniProtKB=F7GR69	Uncharacterized protein	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00019	Endothelin signaling pathway	P00591	PLCbeta	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00059	p53 pathway	P01486	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	IC	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	SULSO|EnsemblGenome=SSO0230|UniProtKB=Q980Q7	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00015	Circadian clock system	G01501	cry	PANTR|Ensembl=ENSPTRG00000005396|UniProtKB=H2Q6S7	Cryptochrome 1 (Photolyase-like)	ISS	14507900	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00021	FGF signaling pathway	P00645	Rac	DICDI|dictyBase=DDB_G0277869|UniProtKB=P34144	Rho-related protein rac1A	ISS	4757952	gi	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95811|UniProtKB=Q9Z2W8	Glutamate receptor 4	ISS	10331083	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P05913	Enkephalin release	P05974	G-Protein (i)	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	IC	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MONDO|Ensembl=ENSMODG00000004799|UniProtKB=F6VM87	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00059	p53 pathway	P04609	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	14526383	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00034	Integrin signalling pathway	P00938	Cdc42	TAKRU|Ensembl=ENSTRUG00000008289|UniProtKB=H2T7U8	Uncharacterized protein	ISS	9658176	PubMed	PTHR24072:SF129	CDC42L PROTEIN
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00014	Cholesterol biosynthesis	P00491	Hydroxymethyl glutaryl CoA reductase	CANLF|Ensembl=ENSCAFG00000009517|UniProtKB=E2R9Z3	3-hydroxy-3-methylglutaryl coenzyme A reductase	ISS	P09610	SPACC	PTHR10572:SF2	3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00057	Wnt signaling pathway	P01438	PP2A	CAEEL|WormBase=WBGene00007554|UniProtKB=A9UJN4	Protein Phosphatase 2A (Two A) Regulatory subunit	ISS	10092233	PubMed	PTHR10257:SF3	PP2A-B', ISOFORM B
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	IDA	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MOUSE|MGI=MGI=95823|UniProtKB=Q03391	Glutamate receptor ionotropic, NMDA 2D	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2D.html	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	DANRE|ZFIN=ZDB-GENE-020503-2|UniProtKB=B0R0Q2	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF498	TYROSINE-PROTEIN KINASE RECEPTOR
P00007	Axon guidance mediated by semaphorins	P00339	CRMP	MONDO|Ensembl=ENSMODG00000016680|UniProtKB=F7DMI7	Uncharacterized protein	ISS	Q90635	SPACC	PTHR11647:SF56	DIHYDROPYRIMIDINASE-RELATED PROTEIN 2
P02742	Tetrahydrofolate biosynthesis	P02951	GTP cyclohydrolase	BOVIN|Ensembl=ENSBTAG00000040151|UniProtKB=F1MZ14	Uncharacterized protein	ISS			PTHR11109:SF0	GTP CYCLOHYDROLASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00029	Huntington disease	P00799	JNK-2	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00029	Huntington disease	P00780	Microtubule	ORYSJ|EnsemblGenome=OS03G0780600|UniProtKB=P37832	Tubulin beta-7 chain	IDA	12932731	PubMed	PTHR11588:SF146	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00558	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	MONDO|Ensembl=ENSMODG00000008900|UniProtKB=F7B4C1	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P05912	Dopamine receptor mediated signaling pathway	P05961	DOPA decarb.	CAEBR|Gene=CBG08967|UniProtKB=A8X844	Protein CBR-BAS-1	ISS	7567987	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00018	EGF receptor signaling pathway	P00565	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	DANRE|ZFIN=ZDB-GENE-990415-223|UniProtKB=Q6NV44	Frizzled homolog 7a	TAS	11212302	PubMed	PTHR11309:SF31	FRIZZLED-7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P05913	Enkephalin release	P05972	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01443	Phospholipase C	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00048	PI3 kinase pathway	P01196	PDK1	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	15210700	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00050	Plasminogen activating cascade	P01245	PAI-1	BOVIN|Ensembl=ENSBTAG00000014465|UniProtKB=P13909	Plasminogen activator inhibitor 1	IDA	3183108	gi	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	NEUCR|EnsemblGenome=EFNCRG00000008511|UniProtKB=V5IKK0	Syntaxin family protein	IC			PTHR19957:SF147	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	CHICK|Ensembl=ENSGALG00000007039|UniProtKB=F1NG99	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P06664	Gonadotropin-releasing hormone receptor pathway	P06847	JNK1/2	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	RCA	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00029	Huntington disease	P00775	Rac	CHICK|Ensembl=ENSGALG00000002859|UniProtKB=F6UBD2	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	RCA	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00024	Glycolysis	P00678	Enolase	RAT|RGD=2554|UniProtKB=P07323	Gamma-enolase	ISS	86042683	PubMed	PTHR11902:SF10	GAMMA-ENOLASE
P00005	Angiogenesis	P00243	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01152	RasGAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	ISS	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_60743|UniProtKB=C3XYD4	Putative uncharacterized protein	ISS			PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00053	T cell activation	P01335	jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00005	Angiogenesis	P00206	Wnt	HUMAN|HGNC=12775|UniProtKB=O00744	Protein Wnt-10b	IEP	11266476	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04567	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02740	De novo pyrimidine ribonucleotides biosythesis	P02922	Orotate phosphoribosyltransferase	CAEEL|WormBase=WBGene00020036|UniProtKB=O61790	Uncharacterized protein	ISS			PTHR19278:SF33	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00983	Raf	MOUSE|MGI=MGI=88190|UniProtKB=P28028	Serine/threonine-protein kinase B-raf	ISS	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00057	Wnt signaling pathway	P01435	SWI/SNF	MOUSE|MGI=MGI=1196437|UniProtKB=Q6PCN7	Helicase-like transcription factor	IDA	11532957	PubMed	PTHR10799:SF870	HELICASE-LIKE TRANSCRIPTION FACTOR
P00047	PDGF signaling pathway	P01143	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01312	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02770	Pyridoxal phosphate salvage pathway	P03121	Pyridoxal kinase	DICDI|dictyBase=DDB_G0268628|UniProtKB=Q55EK9	Pyridoxal kinase	ISS	10930737	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P00018	EGF receptor signaling pathway	P00557	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	ISS	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P00053	T cell activation	P01312	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IDA	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	NAS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	PHYPA|Gene=PHYPADRAFT_185037|UniProtKB=A9SHH7	Predicted protein	ISS	10487978	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00021	FGF signaling pathway	P00632	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	P01486	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=11433|UniProtKB=Q16623	Syntaxin-1A	ISS	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00025	Hedgehog signaling pathway	P00682	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P06664	Gonadotropin-releasing hormone receptor pathway	P06831	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	RCA	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00092	TACE	MOUSE|MGI=MGI=1096335|UniProtKB=Q9Z0F8	Disintegrin and metalloproteinase domain-containing protein 17	IDA	9774383	PubMed	PTHR11905:SF171	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00030	Hypoxia response via HIF activation	P00825	Thioredoxin	PANTR|Ensembl=ENSPTRG00000021245|UniProtKB=H2QXP0	Thioredoxin	ISS	12115731	PubMed	PTHR10438:SF18	THIOREDOXIN
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00037	Ionotropic glutamate receptor pathway	P01026	KA	XENTR|Xenbase=XB-GENE-957124|UniProtKB=F7BDN8	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00021	FGF signaling pathway	P00640	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IGI	129387	gi	PTHR10048:SF14	PI-3 KINASE
P00057	Wnt signaling pathway	P01435	SWI/SNF	CANLF|Ensembl=ENSCAFG00000009492|UniProtKB=F1PKX5	Uncharacterized protein	ISS	11532957	PubMed	PTHR10799:SF868	DNA HELICASE INO80
P05918	p38 MAPK pathway	P06018	MNK1	MACMU|Ensembl=ENSMMUG00000020162|UniProtKB=F6TJV6	Uncharacterized protein	ISS	11575158	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	176910	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00060	Ubiquitin proteasome pathway	P01491	E2	PANTR|Ensembl=ENSPTRG00000028180|UniProtKB=H2R4I1	Uncharacterized protein	ISS			PTHR43902:SF3	UBIQUITIN-CONJUGATING ENZYME E2 N-LIKE-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000022000|UniProtKB=Q9MZL5	Voltage-dependent L-type calcium channel subunit beta-2	IC	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00034	Integrin signalling pathway	P00907	ERK	RAT|RGD=62087|UniProtKB=P27704	Mitogen-activated protein kinase 6	ISS	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00034	Integrin signalling pathway	P00916	Ras	CANLF|Ensembl=ENSCAFG00000003604|UniProtKB=E2R5G6	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF245	RAS-RELATED PROTEIN R-RAS
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	TAS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00046	Oxidative stress response	P01132	c-jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04392	P53 pathway feedback loops 1	G04686	p73	DANRE|ZFIN=ZDB-GENE-030814-2|UniProtKB=B0S576	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CANLF|Ensembl=ENSCAFG00000012181|UniProtKB=F2Z4N7	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ORYSJ|EnsemblGenome=OS06G0154500|UniProtKB=Q84UI5	Mitogen-activated protein kinase 1	ISS	10851062	PubMed	PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P05731	GABA-B receptor II signaling	P05754	Ggamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00629	PP2A	DANRE|ZFIN=ZDB-GENE-040426-877|UniProtKB=F1Q6Z7	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01192	p110	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01189	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00036	Interleukin signaling pathway	P00972	MNK1/2	BOVIN|Ensembl=ENSBTAG00000018049|UniProtKB=E1BCH7	Uncharacterized protein	ISS	9155017	PubMed	PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000016097|UniProtKB=E1B9S9	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	DANRE|ZFIN=ZDB-GENE-040625-167|UniProtKB=Q6IQP4	RAP1A, member of RAS oncogene family	ISS	1904317	PubMed	PTHR24070:SF284	RAP1A, MEMBER OF RAS ONCOGENE FAMILY
P00005	Angiogenesis	P00223	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01443	Phospholipase C	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P02721	ATP synthesis	P02798	Cyt C	XENTR|Xenbase=XB-GENE-5931974|UniProtKB=Q640U4	Cytochrome c, somatic	ISS	11836241	PubMed	PTHR11961:SF12	CYTOCHROME C
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	HUMAN|HGNC=236|UniProtKB=O95622	Adenylate cyclase type 5	ISS	94139935	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P05915	Opioid proenkephalin pathway	P05994	G-protein	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00053	T cell activation	P01336	Jnk	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00047	PDGF signaling pathway	P01140	ELK	HUMAN|HGNC=3326|UniProtKB=P28324	ETS domain-containing protein Elk-4	ISS	11846562	PubMed	PTHR11849:SF21	ETS DOMAIN-CONTAINING PROTEIN ELK-4
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00048	PI3 kinase pathway	P01188	Gbetagamma	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P05916	Opioid prodynorphin pathway	P06002	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04393	Ras Pathway	P04567	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00920	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00053	T cell activation	P01312	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	MACMU|Ensembl=ENSMMUG00000000293|UniProtKB=F6YFG3	Uncharacterized protein	ISS	9362521	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P00011	Blood coagulation	P00411	PAI-1	RAT|RGD=3249|UniProtKB=P20961	Plasminogen activator inhibitor 1	ISS	6981332	gi	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00048	PI3 kinase pathway	P01199	Galpha	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	DANRE|Ensembl=ENSDARG00000074274|UniProtKB=E7FDD7	Uncharacterized protein	ISS	11313498	gi	PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P00019	Endothelin signaling pathway	P00588	ET1-4	PANTR|Ensembl=ENSPTRG00000017730|UniProtKB=H2QSB1	Uncharacterized protein	ISS	15117818	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P00006	Apoptosis signaling pathway	P00302	ATF	PANTR|Ensembl=ENSPTRG00000012660|UniProtKB=H2QJ07	Activating transcription factor 2	ISS	7875593	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	PANTR|Ensembl=ENSPTRG00000002995|UniProtKB=H2Q2N8	Regulator of G-protein signaling 10	ISS	8756726	PubMed	PTHR10845:SF182	REGULATOR OF G-PROTEIN SIGNALING 10
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P06212	DPP-SCW signaling pathway	P06261	PPM1A	DROME|FlyBase=FBgn0086361|UniProtKB=Q961C5	Alphabet, isoform E	IEA	http://flybase.org/reports/FBgn0086361.html	Website	PTHR13832:SF524	PROTEIN PHOSPHATASE 1A, MAGNESIUM DEPENDENT, ALPHA ISOFORM-RELATED
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00037	Ionotropic glutamate receptor pathway	P01018	Glu1	TAKRU|Ensembl=ENSTRUG00000005608|UniProtKB=H2SM93	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00030	Hypoxia response via HIF activation	P00824	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	TAS	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	XENTR|Xenbase=XB-GENE-854877|UniProtKB=F7C949	Presenilin	ISS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00012	Cadherin signaling pathway	P00471	Cadherin	BOVIN|Ensembl=ENSBTAG00000001739|UniProtKB=E1BAM8	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF84	CADHERIN-20
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CANLF|Ensembl=ENSCAFG00000009203|UniProtKB=F1PVZ1	Muscarinic acetylcholine receptor	ISS	11166329	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00056	VEGF signaling pathway	P01408	Akt/PKB	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	ISS	95181376	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P02749	Leucine biosynthesis	P02999	2-Isopropylmalate synthase	METAC|EnsemblGenome=MA_4615|UniProtKB=Q8THA5	Probable 2-isopropylmalate synthase	ISS			PTHR10277:SF55	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	TAS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CAEEL|WormBase=WBGene00009595|UniProtKB=Q7JMS5	Uncharacterized protein	TAS	10664585	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00539	14-3-3	MONDO|Ensembl=ENSMODG00000013658|UniProtKB=F6TY10	Uncharacterized protein	ISS	22165492	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04456	ProCRF (Pro Corticotropin-Releasing Factor)	HUMAN|HGNC=2355|UniProtKB=P06850	Corticoliberin	ISS	122560	OMIM	PTHR15035:SF9	CORTICOLIBERIN
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	BRAFL|Gene=BRAFLDRAFT_115565|UniProtKB=C3XYD3	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00053	T cell activation	P01305	Calmodulin	RAT|RGD=2257|UniProtKB=P62161	Calmodulin	ISS	9753452	PubMed	PTHR23050:SF311	CALMODULIN
P00034	Integrin signalling pathway	P00940	Src	RAT|RGD=620795|UniProtKB=Q9WUD9	Proto-oncogene tyrosine-protein kinase Src	IPI	8054685	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00048	PI3 kinase pathway	P01179	PKB	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	TAS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00023	General transcription regulation	P00668	TFIIB	CHICK|Ensembl=ENSGALG00000006205|UniProtKB=F1NXP2	Uncharacterized protein	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	RCA	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00525	N-WASP	CHICK|Ensembl=ENSGALG00000008797|UniProtKB=E1BTH9	Uncharacterized protein	ISS	12932731	PubMed	PTHR23202:SF39	NEURAL WISKOTT-ALDRICH SYNDROME PROTEIN
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00059	p53 pathway	P04626	GADD45	MONDO|Ensembl=ENSMODG00000000788|UniProtKB=F6SSE6	Uncharacterized protein	ISS	10097101	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IGI	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	10218114	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00056	VEGF signaling pathway	P01412	HSP27	BOVIN|Ensembl=ENSBTAG00000000440|UniProtKB=F1MBR1	Heat shock 27kDa protein 2	ISS			PTHR11527:SF163	HEAT SHOCK PROTEIN BETA-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05925	beta-ARR1	CANLF|Ensembl=ENSCAFG00000005415|UniProtKB=F1PQM2	Uncharacterized protein	ISS	9388255	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00029	Huntington disease	P00781	Dynactin	CANLF|Ensembl=ENSCAFG00000008608|UniProtKB=F6UMF1	Uncharacterized protein	ISS	9454836	PubMed	PTHR18916:SF40	DYNACTIN SUBUNIT 1
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=98959|UniProtKB=P22726	Protein Wnt-5b	IDA	8717036	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02747	Histidine biosynthesis	P02990	Histidinol-phosphatase	SCHPO|PomBase=SPCC1672.01|UniProtKB=O14059	Probable histidinol-phosphatase	ISS			PTHR21039:SF0	HISTIDINOL-PHOSPHATASE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P02776	Serine glycine biosynthesis	P03157	Phosphoserine aminotransferase	CAEBR|Gene=CBG22021|UniProtKB=A8Y1C7	Phosphoserine aminotransferase	ISS			PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P00018	EGF receptor signaling pathway	P00551	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00568	PKC	CAEEL|WormBase=WBGene00018620|UniProtKB=O44588	Uncharacterized protein	ISS	3045562	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	92020947	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MACMU|Ensembl=ENSMMUG00000012054|UniProtKB=F6TII3	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P04377	Beta1 adrenergic receptor signaling pathway	P04433	Beta1	RAT|RGD=2059|UniProtKB=P18090	Beta-1 adrenergic receptor	ISS	12730078	PubMed	PTHR24248:SF54	BETA-1 ADRENERGIC RECEPTOR
P00018	EGF receptor signaling pathway	P00543	ERK1-2	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	IGI	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00047	PDGF signaling pathway	P01160	IP3 receptor	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00052	TGF-beta signaling pathway	P01275	P38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	TAS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000012777|UniProtKB=F7EIF1	Uncharacterized protein	ISS	8120095	PubMed	PTHR43912:SF1	PROTOCADHERIN-11 X-LINKED-RELATED
P00053	T cell activation	P01324	rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12176041	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00046	Oxidative stress response	P01129	JNK1/2	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00238	Ras	MONDO|Ensembl=ENSMODG00000025248|UniProtKB=F7F5X1	Uncharacterized protein	ISS	3023884	PubMed	PTHR24070:SF186	GTPASE KRAS
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00059	p53 pathway	P04616	PDK1/2	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	TAS	15531926	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00014	Cholesterol biosynthesis	P00492	Mevalonate kinase	MOUSE|MGI=MGI=107624|UniProtKB=Q9R008	Mevalonate kinase	ISS			PTHR43290:SF2	MEVALONATE KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000009766|UniProtKB=F6TFL4	Uncharacterized protein	ISS	8444355	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00047	PDGF signaling pathway	P01151	PKB	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00034	Integrin signalling pathway	P00940	Src	MONDO|Ensembl=ENSMODG00000000247|UniProtKB=F6WR53	Tyrosine-protein kinase	ISS	8054685	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00057	Wnt signaling pathway	P01471	alpha-catenin	HUMAN|HGNC=2510|UniProtKB=P26232	Catenin alpha-2	IDA	1768802	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00006	Apoptosis signaling pathway	P00321	HSP70	RAT|RGD=2843|UniProtKB=P06761	78 kDa glucose-regulated protein	ISS	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00056	VEGF signaling pathway	P01417	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05972	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	89107990	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00048	PI3 kinase pathway	P01177	P110ACT	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CAEBR|Gene=CBG05858|UniProtKB=A8X1H0	Protein CBR-EGL-19 (Fragment)	ISS	91056091	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	HUMAN|HGNC=4411|UniProtKB=P63211	Guanine nucleotide-binding protein G(T) subunit gamma-T1	IDA	3100519	PubMed	PTHR13809:SF26	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT GAMMA-T1
P00036	Interleukin signaling pathway	P00965	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00050	Plasminogen activating cascade	P01253	Fibrin	MACMU|Ensembl=ENSMMUG00000021304|UniProtKB=F6UYY8	Uncharacterized protein	ISS	223170	gi	PTHR19143:SF338	FIBRINOGEN GAMMA CHAIN
P00018	EGF receptor signaling pathway	P00563	Gab	HUMAN|HGNC=17515|UniProtKB=Q8WWW8	GRB2-associated-binding protein 3	IGI	11739737	PubMed	PTHR12156:SF2	GRB2-ASSOCIATED-BINDING PROTEIN 3
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	9199552	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P02775	Salvage pyrimidine ribonucleotides	P03150	Uridine kinase	CAEEL|WormBase=WBGene00008948|UniProtKB=H2L2A8	Uridine kinase	ISS			PTHR10285:SF123	URIDINE KINASE
P00015	Circadian clock system	P00505	Cry	MACMU|Ensembl=ENSMMUG00000002453|UniProtKB=F7HH05	Cryptochrome-2	ISS	11533252	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00010	B cell activation	P00398	IP3R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	IGI	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00920	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	HUMAN|HGNC=3418|UniProtKB=P07814	Bifunctional glutamate/proline--tRNA ligase	ISS			PTHR43382:SF2	BIFUNCTIONAL GLUTAMATE/PROLINE--TRNA LIGASE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DICDI|dictyBase=DDB_G0283907|UniProtKB=P34099	cAMP-dependent protein kinase catalytic subunit	IC	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00056	VEGF signaling pathway	P01423	p38MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	TAS	11591316	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	RAT|RGD=2027|UniProtKB=P63269	Actin, gamma-enteric smooth muscle	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P02747	Histidine biosynthesis	P02985	Histidinol dehydrogenase	STRCO|EnsemblGenome=CAB51446|UniProtKB=P16245	Histidinol dehydrogenase	ISS			PTHR21256:SF2	HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P02769	Purine metabolism	P03117	5'-AMP Deaminase	YEAST|SGD=S000004498|UniProtKB=P15274	AMP deaminase	TAS	2690949	PubMed	PTHR11359:SF0	AMP DEAMINASE, ISOFORM K
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	TAS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00012	Cadherin signaling pathway	P00475	Frizzled	XENTR|Xenbase=XB-GENE-483731|UniProtKB=Q5BL72	Frizzled-7	ISS	11212302	PubMed	PTHR11309:SF31	FRIZZLED-7
P00012	Cadherin signaling pathway	P00477	GSK3beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00049	Parkinson disease	P01238	14-3-3	DANRE|ZFIN=ZDB-GENE-030131-6583|UniProtKB=Q5PRD0	14-3-3 protein beta/alpha-A	ISS	9055384	gi	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00048	PI3 kinase pathway	P01185	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00949	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	7798194	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05918	p38 MAPK pathway	P06026	MEKK4	HUMAN|HGNC=6856|UniProtKB=Q9Y6R4	Mitogen-activated protein kinase kinase kinase 4	IDA	12878610	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008422|UniProtKB=F6VUT7	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	HUMAN|HGNC=4579|UniProtKB=P39086	Glutamate receptor ionotropic, kainate 1	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00036	Interleukin signaling pathway	P00968	Ikk	HUMAN|HGNC=5960|UniProtKB=O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	IC	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00021	FGF signaling pathway	P00642	MEK1-2	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00796	Kainate receptor	PANTR|Gene=GRIK4|UniProtKB=Q5IS46	Glutamate receptor ionotropic, kainate 4	ISS	12871085	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	BOVIN|Ensembl=ENSBTAG00000018035|UniProtKB=O46680	TGF-beta receptor type-1	TAS	9395284	PubMed	PTHR23255:SF61	TGF-BETA RECEPTOR TYPE-1
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	CAEBR|Gene=CBG14224|UniProtKB=A8XJJ7	Protein CBR-GLT-1	ISS	96032356	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	MONDO|Ensembl=ENSMODG00000008920|UniProtKB=F7GL76	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P04397	p53 pathway by glucose deprivation	P04640	p53	DANRE|ZFIN=ZDB-GENE-030814-2|UniProtKB=B0S576	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04384	Gamma-aminobutyric acid synthesis	P04481	Succinic semialdehyde dehydrogenase	PSEAE|EnsemblGenome=PA0265|UniProtKB=Q9I6M5	Glutarate-semialdehyde dehydrogenase DavD	IC			PTHR43353:SF5	SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL
P00034	Integrin signalling pathway	P00931	Integrin beta	ORNAN|Ensembl=ENSOANG00000006060|UniProtKB=F6PNT9	Integrin beta	ISS	10706722	PubMed	PTHR10082:SF28	INTEGRIN BETA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	14526383	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01143	ERK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00010	B cell activation	P00375	Calmodulin	CANLF|Ensembl=ENSCAFG00000017516|UniProtKB=E2REK6	Uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF311	CALMODULIN
P00046	Oxidative stress response	P01130	CHOP	BOVIN|Ensembl=ENSBTAG00000031544|UniProtKB=Q0IIB6	DNA damage-inducible transcript 3 protein	ISS	10207617	PubMed	PTHR16833:SF0	DNA DAMAGE-INDUCIBLE TRANSCRIPT 3 PROTEIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	PANTR|Ensembl=ENSPTRG00000009552|UniProtKB=H2QDP8	Uncharacterized protein	ISS	9459445	PubMed	PTHR10845:SF170	REGULATOR OF G-PROTEIN SIGNALING 9
P00057	Wnt signaling pathway	P01443	Phospholipase C	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IDA	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=11331|UniProtKB=P30874	Somatostatin receptor type 2	IDA	12181435	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P00054	Toll receptor signaling pathway	P01378	IRAKM	HUMAN|HGNC=17020|UniProtKB=Q9Y616	Interleukin-1 receptor-associated kinase 3	ISS			PTHR24419:SF7	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 3
P00034	Integrin signalling pathway	P00924	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00648	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00029	Huntington disease	P00812	Caspase 3	RAT|RGD=2275|UniProtKB=P55213	Caspase-3	IDA	11675509	PubMed	PTHR10454:SF198	CASPASE-3
P06664	Gonadotropin-releasing hormone receptor pathway	P06834	MAP3Ks	MOUSE|MGI=MGI=1346878|UniProtKB=Q07174	Mitogen-activated protein kinase kinase kinase 8	RCA	92019818	PubMed	PTHR24361:SF94	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 8
P00034	Integrin signalling pathway	P00936	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01451	Galpha	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02774	Salvage pyrimidine deoxyribonucleotides	P03146	Deoxyuridine kinase	PYRAE|EnsemblGenome=PAE2453|UniProtKB=Q8ZV53	Thymidine kinase	ISS			PTHR11441:SF0	THYMIDINE KINASE, CYTOSOLIC
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00024	Glycolysis	P00678	Enolase	ECOLI|EcoGene=EG10258|UniProtKB=P0A6P9	Enolase	RCA			PTHR11902:SF1	ENOLASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	RCA	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P02788	Xanthine and guanine salvage pathway	P03245	Guanine phosphoribosyl transferase	MACMU|Ensembl=ENSMMUG00000008303|UniProtKB=F7H6Y5	Uncharacterized protein	ISS			PTHR43340:SF6	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00375	Calmodulin	BRAFL|Gene=BRAFLDRAFT_87235|UniProtKB=C3ZEV9	Putative uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF245	AT16150P-RELATED
P05913	Enkephalin release	P05976	Enkephalin	BOVIN|Ensembl=ENSBTAG00000004924|UniProtKB=P01211	Proenkephalin-A	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MACMU|Ensembl=ENSMMUG00000022347|UniProtKB=F6ZCH5	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00057	Wnt signaling pathway	P01428	Frizzled	HUMAN|HGNC=4047|UniProtKB=O00144	Frizzled-9	IDA	11212302	PubMed	PTHR11309:SF79	FRIZZLED-9
P00053	T cell activation	P01336	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04392	P53 pathway feedback loops 1	G04683	Cop-1	ORNAN|Ensembl=ENSOANG00000000942|UniProtKB=F6PJK3	Uncharacterized protein	ISS	15103385	PubMed	PTHR44080:SF1	E3 UBIQUITIN-PROTEIN LIGASE RFWD2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	TAS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01080	AChE	CAEEL|WormBase=WBGene00000035|UniProtKB=P38433	Acetylcholinesterase 1	IC			PTHR43918:SF3	ACETYLCHOLINESTERASE
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00054	Toll receptor signaling pathway	P01369	MKK1	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00025	Hedgehog signaling pathway	P00691	CBP	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P02738	De novo purine biosynthesis	P02898	Phosphoribosylformylglycinamide  synthase	AQUAE|EnsemblGenome=aq_1105|UniProtKB=O67190	Phosphoribosylformylglycinamidine synthase subunit PurQ	ISS			PTHR10099:SF1	PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01026	KA	PANTR|Ensembl=ENSPTRG00000011042|UniProtKB=H2QGF5	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	MOUSE|MGI=MGI=94927|UniProtKB=Q8BLD9	D(1B) dopamine receptor	ISS	11861492	PubMed	PTHR43893:SF8	D 1B  DOPAMINE RECEPTOR
P00057	Wnt signaling pathway	P01457	GBeta	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00048	PI3 kinase pathway	P01177	P110ACT	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00010	B cell activation	P00384	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00034	Integrin signalling pathway	P00924	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IPI	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02765	Phenylalanine biosynthesis	P03100	Chorismate mutase	YEAST|SGD=S000006264|UniProtKB=P32178	Chorismate mutase	ISS			PTHR21145:SF0	CHORISMATE MUTASE
P02778	Sulfate assimilation	P03164	Adenylylsulfate kinase	BACSU|EnsemblGenome=BSU15600|UniProtKB=O34577	Probable adenylyl-sulfate kinase	ISS			PTHR11055:SF33	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00221	JNK1	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	BOVIN|Ensembl=ENSBTAG00000000219|UniProtKB=F1MCL3	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00018	EGF receptor signaling pathway	P00559	MEK1-2	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-486685|UniProtKB=F6VT32	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00019	Endothelin signaling pathway	P00589	Akt	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	IGI	22081553	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00366	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12676940	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00059	p53 pathway	P04633	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	RAT|RGD=2517|UniProtKB=P47942	Dihydropyrimidinase-related protein 2	TAS	7637782	PubMed	PTHR11647:SF56	DIHYDROPYRIMIDINASE-RELATED PROTEIN 2
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS			PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00777	CBP	CAEEL|WormBase=WBGene00009595|UniProtKB=Q7JMS5	Uncharacterized protein	IDA	10823891	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	ANOGA|EnsemblGenome=AGAP005912|UniProtKB=Q7Q6D3	AGAP005912-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00010	B cell activation	P00391	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00011	Blood coagulation	P00444	FIX	BOVIN|Ensembl=ENSBTAG00000004003|UniProtKB=P00741	Coagulation factor IX	ISS	119769	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P00021	FGF signaling pathway	P00641	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00047	PDGF signaling pathway	P01159	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00047	PDGF signaling pathway	P01148	Grb2	MOUSE|MGI=MGI=1918770|UniProtKB=Q9CX99	GRB2-related adapter protein	ISS	9741627	PubMed	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00010	B cell activation	P00373	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	BOVIN|Ensembl=ENSBTAG00000047202|UniProtKB=G3N3K3	Uncharacterized protein	ISS	11554554	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00005	Angiogenesis	P00233	CSL	BOVIN|Ensembl=ENSBTAG00000003602|UniProtKB=Q3SZ41	Recombining binding protein suppressor of hairless	ISS	9043084	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IDA	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00025	Hedgehog signaling pathway	P00682	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00049	Parkinson disease	P01227	20S proteasome	PLAF7|EnsemblGenome=MAL8P1.142|UniProtKB=Q7K6A9	Proteasome subunit beta type	ISS	12859888	PubMed	PTHR11599:SF5	PROTEASOME SUBUNIT BETA TYPE-4
P00005	Angiogenesis	P00189	Fzd	ORNAN|Ensembl=ENSOANG00000004982|UniProtKB=F7DIA9	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF34	FRIZZLED-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	RAT|RGD=2740|UniProtKB=Q62645	Glutamate receptor ionotropic, NMDA 2D	IC	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00006	Apoptosis signaling pathway	P00274	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	IC	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P06664	Gonadotropin-releasing hormone receptor pathway	P06831	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	RCA	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	DROME|FlyBase=FBgn0036790|UniProtKB=Q9VVQ1	Allatostatin C receptor 1	IDA	12181435	PubMed	PTHR24229:SF51	ALLATOSTATIN C RECEPTOR 1-RELATED
P00020	FAS signaling pathway	P00608	Pro-Caspase3	CHICK|Ensembl=ENSGALG00000010638|UniProtKB=O93417	Caspase-3	IGI	9323209	PubMed	PTHR10454:SF198	CASPASE-3
P00010	B cell activation	P00379	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00019	Endothelin signaling pathway	P00566	ERK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	ARATH|TAIR=AT3G45640|UniProtKB=Q39023	Mitogen-activated protein kinase 3	TAS			PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00778	NMDA receptor	HUMAN|HGNC=4586|UniProtKB=Q13224	Glutamate receptor ionotropic, NMDA 2B	IDA	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04413	K+ channel	PANTR|Ensembl=ENSPTRG00000020614|UniProtKB=H2QWR7	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00021	FGF signaling pathway	P00627	ERK1-2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01159	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02755	Methylmalonyl pathway	P03034	Methylmalonyl-CoA mutase	PANTR|Ensembl=ENSPTRG00000018256|UniProtKB=H2QT52	Methylmalonyl CoA mutase	ISS			PTHR42710:SF1	METHYLMALONYL-COA MUTASE, MITOCHONDRIAL
P02752	Mannose metabolism	P03021	GDP Mannose 6-dehydrogenase	PSEAE|EnsemblGenome=PA3159|UniProtKB=G3XD94	UDP-N-acetyl-D-glucosamine 6-dehydrogenase	TAS			PTHR43491:SF1	UDP-N-ACETYL-D-MANNOSAMINE DEHYDROGENASE
P00053	T cell activation	P01332	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02763	Peptidoglycan biosynthesis	P03084	UDP-N-acetylmuramoylalanyl-D-glutamate 2,6-diaminopimelate ligase	AQUAE|EnsemblGenome=aq_1747|UniProtKB=O67631	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase	ISS			PTHR23135:SF4	UDP-N-ACETYLMUAMOYLALANYL-D-GLUTAMATE-2,6-DIAMINOPIMELATE LIGASE-RELATED
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	DANRE|ZFIN=ZDB-GENE-051129-1|UniProtKB=Q4JLT0	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P04393	Ras Pathway	P04559	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00050	Plasminogen activating cascade	P01256	uPAR	HUMAN|HGNC=9053|UniProtKB=Q03405	Urokinase plasminogen activator surface receptor	IEA	13641309	gi	PTHR10624:SF6	UROKINASE PLASMINOGEN ACTIVATOR SURFACE RECEPTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	IDA	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00047	PDGF signaling pathway	P01150	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00643	Raf-1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01194	S6K	MOUSE|MGI=MGI=1927343|UniProtKB=Q9Z1M4	Ribosomal protein S6 kinase beta-2	IDA	6755374	gi	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06852	nPKCs	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=1310903|UniProtKB=D4A978	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF33	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-3
P00036	Interleukin signaling pathway	P00980	IRS1/2	PANTR|Ensembl=ENSPTRG00000012989|UniProtKB=H2QJJ4	Insulin receptor substrate 1	ISS	5031805	gi	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00021	FGF signaling pathway	P00632	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000003762|UniProtKB=A5PJS1	GNB5 protein	ISS	10051575	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	ANOGA|EnsemblGenome=AGAP002578|UniProtKB=F5HKU8	AGAP002578-PB	ISS	14507926	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P00052	TGF-beta signaling pathway	P01284	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	P01457	GBeta	NEUCR|EnsemblGenome=EFNCRG00000000159|UniProtKB=F5HH30	Guanine nucleotide-binding protein beta subunit	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BOVIN|Ensembl=ENSBTAG00000035697|UniProtKB=Q28024	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	TAS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00053	T cell activation	P01299	TCR Beta	MACMU|Ensembl=ENSMMUG00000030072|UniProtKB=F7H9P0	Uncharacterized protein	ISS			PTHR23268:SF74	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05960	VAT2	BOVIN|Gene=SLC18A2|UniProtKB=Q27963	Synaptic vesicular amine transporter	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P05913	Enkephalin release	P05974	G-Protein (i)	DROME|FlyBase=FBgn0030011|UniProtKB=Q9W3J1	Gbeta5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	G04694	p110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00566	ERK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	IGI	10851062	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P02723	Adenine and hypoxanthine salvage pathway	P02807	Deoxyadenosine deaminase	CAEEL|WormBase=WBGene00015551|UniProtKB=H2KYI5	Uncharacterized protein	ISS			PTHR11409:SF43	ADENOSINE DEAMINASE
P04393	Ras Pathway	P04558	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IDA	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00047	PDGF signaling pathway	P01151	PKB	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	MOUSE|MGI=MGI=97579|UniProtKB=P07934	Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	IDA	1370475	PubMed	PTHR44087:SF1	PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, SKELETAL MUSCLE/HEART ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00029	Huntington disease	P00790	beta-Tubulin	TRIVA|Gene=TVAG_008680|UniProtKB=A2DC16	Beta-tubulin, putative	TAS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00019	Endothelin signaling pathway	P00586	Gq	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000040496|UniProtKB=H2RF32	Uncharacterized protein	ISS	8120095	PubMed	PTHR43912:SF3	PROTOCADHERIN-1
P00005	Angiogenesis	P00204	PLD	CANLF|Ensembl=ENSCAFG00000015246|UniProtKB=J9P1D8	Uncharacterized protein	ISS	15668389	PubMed	PTHR18896:SF57	PHOSPHOLIPASE D1
P00005	Angiogenesis	P00183	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	7680960	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00054	Toll receptor signaling pathway	P01356	ERK2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00010	B cell activation	P00371	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	RAT|RGD=62074|UniProtKB=P18331	Inhibin beta A chain	TAS	11451570	PubMed	PTHR11848:SF133	INHIBIN BETA A CHAIN
P04398	p53 pathway feedback loops 2	P04657	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	1482697	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01422	eNOS	PANTR|Ensembl=ENSPTRG00000019868|UniProtKB=H2QVM2	Nitric oxide synthase	ISS	93055452	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00053	T cell activation	P01300	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04397	p53 pathway by glucose deprivation	P04640	p53	BOVIN|Ensembl=ENSBTAG00000005812|UniProtKB=G3X6J7	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-486685|UniProtKB=F6VT32	Protein kinase C	ISS	11880265	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	XENTR|Xenbase=XB-GENE-999035|UniProtKB=F7CEB1	Uncharacterized protein	ISS	1722329	PubMed	PTHR42884:SF1	FURIN
P00053	T cell activation	P01318	PKC-theta	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00012	Cadherin signaling pathway	P00462	Casein kinase II	CIOIN|Ensembl=ENSCING00000003902|UniProtKB=Q967X2	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=108061|UniProtKB=P48614	Protein Wnt-10b	IDA	8717036	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00021	FGF signaling pathway	P00629	PP2A	TAKRU|Ensembl=ENSTRUG00000011169|UniProtKB=H2TU36	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05915	Opioid proenkephalin pathway	P05993	AC	MOUSE|MGI=MGI=102891|UniProtKB=P51829	Adenylate cyclase type 7	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00036	Interleukin signaling pathway	P00985	PDK1/2	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	DANRE|ZFIN=ZDB-GENE-051202-1|UniProtKB=E7F101	Uncharacterized protein	ISS	14698601	PubMed	PTHR44391:SF2	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01067	AChE	BRAFL|Gene=BRAFLDRAFT_132597|UniProtKB=C3ZRW7	Carboxylic ester hydrolase	ISS	86008285	PubMed	PTHR11559:SF356	ACETYLCHOLINESTERASE
P00012	Cadherin signaling pathway	P00470	F-actin	TAKRU|Ensembl=ENSTRUG00000005447|UniProtKB=P68142	Actin, cytoplasmic 1	IC	10974003	PubMed	PTHR11937:SF354	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00114	actin	RAT|RGD=1309504|UniProtKB=D3ZRN3	Protein Actbl2	ISS	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00036	Interleukin signaling pathway	P00965	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00981	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	TAS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	IC	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00003	Alzheimer disease-amyloid secretase pathway	P00107	kinesin	STRPU|EnsemblGenome=SPU_018898|UniProtKB=Q05090	Kinesin light chain	IDA	11740561	PubMed	PTHR19959:SF207	KINESIN LIGHT CHAIN
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MACMU|Ensembl=ENSMMUG00000020809|UniProtKB=F7H7P8	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P00053	T cell activation	P01318	PKC-theta	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00047	PDGF signaling pathway	P01160	IP3 receptor	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00057	Wnt signaling pathway	P01432	Beta-Catenin	DROME|FlyBase=FBgn0000117|UniProtKB=P18824	Armadillo segment polarity protein	IDA			PTHR23315:SF233	ARMADILLO SEGMENT POLARITY PROTEIN
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	RAT|RGD=3250|UniProtKB=P35465	Serine/threonine-protein kinase PAK 1	ISS	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00057	Wnt signaling pathway	P01440	Cadherin	MONDO|Ensembl=ENSMODG00000004059|UniProtKB=F7BIQ7	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF290	CADHERIN-10
P00047	PDGF signaling pathway	P01162	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	TAS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=1339709|UniProtKB=P13541	Myosin-3	ISS	10938134	PubMed	PTHR13140:SF427	MYOSIN-3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00059	p53 pathway	G04703	Apaf	PANTR|Ensembl=ENSPTRG00000005335|UniProtKB=H2R1S6	Apoptotic protease-activating factor 1	ISS	14526190	PubMed	PTHR22845:SF5	APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
P00049	Parkinson disease	P01240	hSel10	MACMU|Ensembl=ENSMMUG00000016008|UniProtKB=F7FVG8	Uncharacterized protein	ISS			PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P00045	Notch signaling pathway	P01112	CoR	RAT|RGD=1310293|UniProtKB=D3ZXN9	Nuclear receptor co-repressor 2 (Predicted), isoform CRA_a	ISS	10441327	PubMed	PTHR13992:SF21	NUCLEAR RECEPTOR COREPRESSOR 2
P00054	Toll receptor signaling pathway	G01550	Gene trancription	BOVIN|Ensembl=ENSBTAG00000000277|UniProtKB=Q9TU73	Interleukin-18	ISS	10547157	PubMed	PTHR45200:SF1	INTERLEUKIN-18
P02738	De novo purine biosynthesis	P02902	ADP reductase	PSEAE|EnsemblGenome=PA5497|UniProtKB=Q9HT76	NrdJa	ISS			PTHR43371:SF1	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	HUMAN|HGNC=11433|UniProtKB=Q16623	Syntaxin-1A	ISS	1321498	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	MACMU|Ensembl=ENSMMUG00000020531|UniProtKB=F7D8G7	Uncharacterized protein	ISS	12645661	PubMed	PTHR45052:SF1	SUPPRESSOR OF CYTOKINE SIGNALING 7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00047	PDGF signaling pathway	P01163	c-Jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P02774	Salvage pyrimidine deoxyribonucleotides	P03147	Thymidine kinase	THEMA|EnsemblGenome=TM_0401|UniProtKB=Q9WYN2	Thymidine kinase	ISS			PTHR11441:SF0	THYMIDINE KINASE, CYTOSOLIC
P00059	p53 pathway	P04634	Cdc2	RAT|RGD=70486|UniProtKB=Q63699	Cyclin-dependent kinase 2	ISS	1846803	PubMed	PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P00029	Huntington disease	P00807	Actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347740|UniProtKB=E9FXV8	Cytoplasmatic actin	ISS	14684598	PubMed	PTHR11937:SF277	SUBFAMILY NOT NAMED
P02751	Lysine biosynthesis	P03008	Dihydrodipicolinate synthase	IXOSC|EnsemblGenome=ISCW016019|UniProtKB=B7P667	Dihydrodipicolinate synthase, putative	ISS			PTHR12128:SF15	4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00011	Blood coagulation	P00448	vWF	CANLF|Gene=VWF|UniProtKB=Q28295	von Willebrand factor	ISS	193400	OMIM	PTHR11339:SF361	VON WILLEBRAND FACTOR-RELATED
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1354946|UniProtKB=Q61532	Mitogen-activated protein kinase 6	ISS	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00018	EGF receptor signaling pathway	P00547	PP2A	HUMAN|HGNC=9310|UniProtKB=Q15173	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform	ISS	10092233	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00786	ARF	PHANO|EnsemblGenome=SNOG_06879|UniProtKB=Q0UMY5	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00021	FGF signaling pathway	P00627	ERK1-2	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00021	FGF signaling pathway	P00624	14-3-3	ORYSJ|EnsemblGenome=OS04G0462500|UniProtKB=Q7XTE8	14-3-3-like protein GF14-B	ISS	10407019	PubMed	PTHR18860:SF36	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01160	IP3 receptor	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	METAC|EnsemblGenome=MA_0179|UniProtKB=Q8TU94	TATA-box-binding protein 2	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P05730	Endogenous cannabinoid signaling	P05751	Galpha	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00006	Apoptosis signaling pathway	P00310	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00011	Blood coagulation	P00421	alpha1-antitrypsin	HUMAN|HGNC=8941|UniProtKB=P01009	Alpha-1-antitrypsin	ISS	1942629	gi	PTHR11461:SF165	ALPHA-1-ANTITRYPSIN-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04393	Ras Pathway	P04559	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	20264070	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00021	FGF signaling pathway	P00623	FGF	RAT|RGD=71052|UniProtKB=O54769	Fibroblast growth factor 16	ISS	12619867	PubMed	PTHR11486:SF27	FIBROBLAST GROWTH FACTOR 16
P00017	DNA replication	P00538	RNase H	YEAST|SGD=S000003508|UniProtKB=P53331	RNA exonuclease 1	ISS			PTHR12801:SF102	RNA EXONUCLEASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	HUMAN|HGNC=4404|UniProtKB=P59768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IDA	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	CAEEL|WormBase=WBGene00015538|UniProtKB=P50305	Probable S-adenosylmethionine synthase 3	ISS			PTHR11964:SF1	S-ADENOSYLMETHIONINE SYNTHASE
P00057	Wnt signaling pathway	P01451	Galpha	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00018	EGF receptor signaling pathway	P00547	PP2A	DROME|FlyBase=FBgn0042693|UniProtKB=Q8IN89	PP2A-B', isoform B	ISS			PTHR10257:SF3	PP2A-B', ISOFORM B
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00054	Toll receptor signaling pathway	P01352	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00003	Alzheimer disease-amyloid secretase pathway	P00101	BACE-1	MOUSE|MGI=MGI=1346542|UniProtKB=P56818	Beta-secretase 1	IDA	10956649	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06725	TGIF1	HUMAN|HGNC=11776|UniProtKB=Q15583	Homeobox protein TGIF1	RCA			PTHR11850:SF59	HOMEOBOX PROTEIN TGIF1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CAEBR|Gene=CBG17587|UniProtKB=A8XRA5	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P04397	p53 pathway by glucose deprivation	P04642	Rheb	DROME|FlyBase=FBgn0041191|UniProtKB=Q9VND8	GTP-binding protein Rheb homolog	ISS			PTHR24070:SF226	GTP-BINDING PROTEIN RHEB HOMOLOG
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00566	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	RAT|RGD=621005|UniProtKB=Q08849	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00054	Toll receptor signaling pathway	P01368	MKK2	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	TAKRU|Ensembl=ENSTRUG00000006611|UniProtKB=H2SV11	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	CAEEL|WormBase=WBGene00004769|UniProtKB=P52166	Presenilin sel-12	TAS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ORYSJ|EnsemblGenome=OS05G0438800|UniProtKB=Q75HX0	Actin	ISS	14684598	PubMed	PTHR11937:SF248	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	HUMAN|HGNC=4421|UniProtKB=P30968	Gonadotropin-releasing hormone receptor	ISS	1333052	PubMed	PTHR24241:SF22	GONADOTROPIN-RELEASING HORMONE RECEPTOR
P00005	Angiogenesis	P00209	FAK	XENTR|Xenbase=XB-GENE-952025|UniProtKB=F7CW18	Uncharacterized protein	ISS	12640026	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00029	Huntington disease	P00807	Actin	TAKRU|Ensembl=ENSTRUG00000014318|UniProtKB=H2UI49	Uncharacterized protein	IDA	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00012	Cadherin signaling pathway	P00474	Wnt	BOVIN|Ensembl=ENSBTAG00000005570|UniProtKB=E1BKL2	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BRAFL|Gene=BRAFLDRAFT_220697|UniProtKB=C3ZSF0	Putative uncharacterized protein	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PANTR|Ensembl=ENSPTRG00000010019|UniProtKB=H2QEI7	Uncharacterized protein	ISS			PTHR13140:SF356	UNCONVENTIONAL MYOSIN-VB
P00034	Integrin signalling pathway	P00928	alpha actinin	PANTR|Ensembl=ENSPTRG00000010935|UniProtKB=H2QG89	Actinin, alpha 4	ISS	2116421	PubMed	PTHR43947:SF7	ALPHA-ACTININ-4
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IGI	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00018	EGF receptor signaling pathway	P00551	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00936	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IPI	7565716	PubMed	PTHR10048:SF14	PI-3 KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	RAT|RGD=621516|UniProtKB=G3V6P8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P05918	p38 MAPK pathway	P06036	MKK3	ORNAN|Ensembl=ENSOANG00000007732|UniProtKB=F6PXH5	Uncharacterized protein (Fragment)	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00021	FGF signaling pathway	P00644	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IGI	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00054	Toll receptor signaling pathway	P01360	IKKbeta	MOUSE|MGI=MGI=1338071|UniProtKB=O88351	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00012	Cadherin signaling pathway	P00474	Wnt	BRAFL|Gene=BRAFLDRAFT_271417|UniProtKB=C3ZCG7	Protein Wnt	IDA	8717036	PubMed	PTHR12027:SF102	PROTEIN WNT-4
P00057	Wnt signaling pathway	P01456	beta-arrestin	CANLF|Ensembl=ENSCAFG00000005415|UniProtKB=F1PQM2	Uncharacterized protein	ISS	9388255	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	ISS	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P06664	Gonadotropin-releasing hormone receptor pathway	P06758	DRD2	MOUSE|MGI=MGI=94924|UniProtKB=P61168	D(2) dopamine receptor	RCA	11861492	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DROME|FlyBase=FBgn0003093|UniProtKB=P13678	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00018	EGF receptor signaling pathway	P00565	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00020	FAS signaling pathway	P00615	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=9098358|UniProtKB=D3ZUH2	Protein LOC103690878	ISS			PTHR19957:SF72	PROTEIN GM379
P00019	Endothelin signaling pathway	P00572	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000001384|UniProtKB=F7GL73	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00007	Axon guidance mediated by semaphorins	P00338	Neuropilin 1	RAT|RGD=621588|UniProtKB=Q9QWJ9	Neuropilin-1	IDA	9288754	PubMed	PTHR44185:SF1	NEUROPILIN-1
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00182	p38MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02746	Heme biosynthesis	P02975	Uroporphyrinogen decarboxylase	GLOVI|Gene=BAC90487|UniProtKB=Q7NHI9	Precorrin methylase	ISS			PTHR21091:SF9	SUBFAMILY NOT NAMED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01316	MHC-antigen	MOUSE|MGI=MGI=95923|UniProtKB=Q31099	H2-M beta 2	IPI	3112582	PubMed	PTHR19944:SF65	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DM BETA CHAIN
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	2837282	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00018	EGF receptor signaling pathway	P00543	ERK1-2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01428	Frizzled	RAT|RGD=631406|UniProtKB=Q8CHL0	Frizzled-5	ISS	11212302	PubMed	PTHR11309:SF126	FRIZZLED-5
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00865	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	95096035	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CHICK|Ensembl=ENSGALG00000015835|UniProtKB=F1NZT2	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00018	EGF receptor signaling pathway	P00565	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	10395542	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00047	PDGF signaling pathway	P01162	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00053	T cell activation	P01333	cdc42	TAKRU|Ensembl=ENSTRUG00000008289|UniProtKB=H2T7U8	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF129	CDC42L PROTEIN
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	CANLF|Ensembl=ENSCAFG00000005204|UniProtKB=B6V8E6	Catenin beta-1	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00057	Wnt signaling pathway	P01439	C-terminal Binding Protein	MONDO|Ensembl=ENSMODG00000004380|UniProtKB=F6VTH1	Uncharacterized protein	ISS	10375506	PubMed	PTHR10996:SF128	C-TERMINAL-BINDING PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	CAEEL|WormBase=WBGene00004769|UniProtKB=P52166	Presenilin sel-12	IDA	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P04397	p53 pathway by glucose deprivation	P04636	S6K	XENTR|Xenbase=XB-GENE-482409|UniProtKB=F6UK84	Uncharacterized protein (Fragment)	ISS	11861821	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00558	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00037	Ionotropic glutamate receptor pathway	P01023	CaMKII	XENTR|Xenbase=XB-GENE-868520|UniProtKB=K9J7V0	Uncharacterized protein	ISS	12888804	PubMed	PTHR43940:SF7	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT GAMMA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	MOUSE|MGI=MGI=1915988|UniProtKB=Q99NB1	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ISS			PTHR24095:SF110	ACETYL-COENZYME A SYNTHETASE 2-LIKE, MITOCHONDRIAL
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P02738	De novo purine biosynthesis	P02907	dADP kinase	HUMAN|HGNC=14656|UniProtKB=Q8TD84	Down syndrome cell adhesion molecule-like protein 1	ISS			PTHR44107:SF3	DOWN SYNDROME CELL ADHESION MOLECULE-LIKE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IPI	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	ISS	10704417	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00019	Endothelin signaling pathway	P00590	IP3 R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00057	Wnt signaling pathway	P01438	PP2A	XENTR|Xenbase=XB-GENE-957526|UniProtKB=K9J7P6	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	RAT|RGD=620443|UniProtKB=Q63355	Unconventional myosin-Ic	IC			PTHR13140:SF255	UNCONVENTIONAL MYOSIN-IC
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	DROME|FlyBase=FBgn0065032|UniProtKB=Q9VX82	Actin-related protein 2/3 complex subunit 3	ISS	12473693	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00053	T cell activation	P01305	Calmodulin	MONDO|Ensembl=ENSMODG00000004410|UniProtKB=F6SV58	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF322	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04668	p53	MACMU|Ensembl=ENSMMUG00000008639|UniProtKB=P56424	Cellular tumor antigen p53	TAS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	CANAL|CGD=CAL0006348|UniProtKB=Q59Z23	Likely protein kinase	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	18021322	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00038	JAK/STAT signaling pathway	P01027	STAT	BOVIN|Gene=STAT5A|UniProtKB=Q95115	Signal transducer and activator of transcription 5A	ISS	95236292	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00011	Blood coagulation	P00418	Fibrin monomer	CHICK|Gene=FGB|UniProtKB=Q02020	Fibrinogen beta chain (Fragment)	ISS			PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00004	Alzheimer disease-presenilin pathway	P00118	E-cadherin	RAT|RGD=621089|UniProtKB=F1LMI3	Cadherin 3, type 1, P-cadherin (Placental)	ISS	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IDA	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P02761	Pantothenate biosynthesis	P03068	Pantoate-beta-alanine ligase	SCHPO|PomBase=SPAC5H10.08c|UniProtKB=Q09673	Pantoate--beta-alanine ligase	ISS			PTHR21299:SF1	PANTOATE--BETA-ALANINE LIGASE
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04392	P53 pathway feedback loops 1	G04686	p73	BOVIN|Ensembl=ENSBTAG00000005812|UniProtKB=G3X6J7	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00036	Interleukin signaling pathway	P00979	MAPKAPK2	HUMAN|HGNC=6887|UniProtKB=P49137	MAP kinase-activated protein kinase 2	IDA	10779545	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_94959|UniProtKB=C3XYC4	Putative uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00052	TGF-beta signaling pathway	P01275	P38	DROME|FlyBase=FBgn0015765|UniProtKB=O62618	Mitogen-activated protein kinase 14A	TAS	11274345	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IC	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04393	Ras Pathway	P04561	SRF	PANTR|Ensembl=ENSPTRG00000018189|UniProtKB=H2QT21	Uncharacterized protein	ISS	15170389	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00059	p53 pathway	P01480	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00215	Nck	BOVIN|Ensembl=ENSBTAG00000018427|UniProtKB=Q1LZB2	NCK adaptor protein 1	ISS	11689432	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	CANLF|Ensembl=ENSCAFG00000004090|UniProtKB=F1PNQ0	Uncharacterized protein	ISS	12623444	PubMed	PTHR11920:SF291	ADENYLATE CYCLASE TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ANOGA|EnsemblGenome=AGAP000651|UniProtKB=P84185	Actin-5C	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	DICPU|Gene=DICPUDRAFT_93216|UniProtKB=F1A421	Guanine nucleotide-binding protein subunit beta	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000047062|UniProtKB=G3MX13	Uncharacterized protein	ISS	11907044	PubMed	PTHR44062:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 3
P02746	Heme biosynthesis	P02972	Ferrochelatase	XENTR|Xenbase=XB-GENE-960754|UniProtKB=F6SL08	Ferrochelatase	ISS			PTHR11108:SF1	FERROCHELATASE, MITOCHONDRIAL
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	XENTR|Xenbase=XB-GENE-486781|UniProtKB=F6XWP7	Uncharacterized protein	ISS	9554852	PubMed	PTHR10845:SF11	AXIN-1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	88241036	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00018	EGF receptor signaling pathway	P00551	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10557357	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00012	Cadherin signaling pathway	P00477	GSK3beta	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00049	Parkinson disease	P01242	Casein kinase I	PRIPA|Gene=PPA25500|UniProtKB=H3FT78	Uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	IDA	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P06959	CCKR signaling map	P07228	MAPK1/3	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	RCA		PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00782	alpha-Adaptin	CAEBR|Gene=CBG16158|UniProtKB=A8XNZ9	Protein CBR-APA-2	ISS	11532990	PubMed	PTHR22780:SF4	AP-2 COMPLEX SUBUNIT ALPHA-2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00059	p53 pathway	P04623	CBP	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	IDA	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00036	Interleukin signaling pathway	P00975	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	2574500	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	TAKRU|Ensembl=ENSTRUG00000009851|UniProtKB=H2TJ90	Uncharacterized protein	IGI	21455682	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P02734	Chorismate biosynthesis	P02871	2-Deoxy-7-phosphoheptulonate synthase	ECOLI|EcoGene=EG10080|UniProtKB=P00887	Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive	ISS			PTHR21225:SF6	PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, TRP-SENSITIVE
P00057	Wnt signaling pathway	P01428	Frizzled	PANTR|Ensembl=ENSPTRG00000028542|UniProtKB=H2R591	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF79	FRIZZLED-9
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00021	FGF signaling pathway	P00638	PLCgamma	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	ENTHI|Gene=EHI_020610|UniProtKB=P52653	TATA-box-binding protein 1	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04393	Ras Pathway	P04557	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	IDA	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04393	Ras Pathway	P04572	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IDA	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00015	Circadian clock system	P00501	Clock	RAT|RGD=620271|UniProtKB=Q9WVS9	Circadian locomoter output cycles protein kaput	ISS	8171325	PubMed	PTHR23042:SF2	CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00025	Hedgehog signaling pathway	P00683	Slimb	BOVIN|Ensembl=ENSBTAG00000015376|UniProtKB=F1MLG0	Uncharacterized protein	ISS	12628165	PubMed	PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02913	Thymidylate synthase	PLAF7|EnsemblGenome=PFD0830w|UniProtKB=Q8I1R6	Bifunctional dihydrofolate reductase-thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00029	Huntington disease	P00799	JNK-2	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00019	Endothelin signaling pathway	P00570	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01196	PDK1	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	12855688	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05915	Opioid proenkephalin pathway	P05994	G-protein	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00046	Oxidative stress response	P01122	TRX	NEUCR|Gene=NCU06556|UniProtKB=F5HBN4	Thioredoxin II	ISS			PTHR10438:SF360	THIOREDOXIN H9-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHLRE|EnsemblGenome=CHLREDRAFT_24392|UniProtKB=A8JAV1	Actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	HUMAN|HGNC=1388|UniProtKB=O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	15699344	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00830	Lipoxygenase	MOUSE|MGI=MGI=87998|UniProtKB=P39655	Arachidonate 12-lipoxygenase, 12S-type	TAS	12432925	PubMed	PTHR11771:SF4	ARACHIDONATE 12-LIPOXYGENASE, 12S-TYPE
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9408|UniProtKB=O94806	Serine/threonine-protein kinase D3	ISS	12676944	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P02750	Lipoate_biosynthesis	P03004	Lipoate synthase	PSEAE|EnsemblGenome=PA3996|UniProtKB=Q9HX25	Lipoyl synthase	ISS			PTHR10949:SF24	LIPOYL SYNTHASE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00029	Huntington disease	P00796	Kainate receptor	MONDO|Ensembl=ENSMODG00000013079|UniProtKB=F7FB74	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00047	PDGF signaling pathway	P01148	Grb2	BOVIN|Ensembl=ENSBTAG00000003707|UniProtKB=A6QLK6	GRB2-related adapter protein	ISS	8647802	PubMed	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P00014	Cholesterol biosynthesis	P00491	Hydroxymethyl glutaryl CoA reductase	MOUSE|MGI=MGI=96159|UniProtKB=Q01237	3-hydroxy-3-methylglutaryl-coenzyme A reductase	ISS	P09610	SPACC	PTHR10572:SF2	3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE
P00057	Wnt signaling pathway	P01471	alpha-catenin	MONDO|Ensembl=ENSMODG00000015456|UniProtKB=F6S406	Uncharacterized protein	ISS	1638632	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P00010	B cell activation	P00381	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00172	BACE-1	PANTR|Ensembl=ENSPTRG00000004324|UniProtKB=H2Q4U8	Beta-site APP-cleaving enzyme 1	ISS	10956649	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00056	VEGF signaling pathway	P01419	Ets	MONDO|Ensembl=ENSMODG00000004730|UniProtKB=F6Y1Z2	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P04393	Ras Pathway	P04548	ATF2	HUMAN|HGNC=784|UniProtKB=P15336	Cyclic AMP-dependent transcription factor ATF-2	ISS	9819389	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00019	Endothelin signaling pathway	P00566	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01307	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P06587	Nicotine pharmacodynamics pathway	P06610	CHRNB4	HUMAN|HGNC=1964|UniProtKB=P30926	Neuronal acetylcholine receptor subunit beta-4	TAS	22213672	PubMed	PTHR18945:SF385	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-4
P00056	VEGF signaling pathway	P01411	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00973	PKB	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00636	FGFR1-4	RAT|RGD=2612|UniProtKB=Q498D6	Fibroblast growth factor receptor 4	ISS	12466116	PubMed	PTHR24416:SF343	FIBROBLAST GROWTH FACTOR RECEPTOR 4
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8972|UniProtKB=O00750	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00006	Apoptosis signaling pathway	P00310	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04578	Rho	CHICK|Ensembl=ENSGALG00000003806|UniProtKB=O93467	GTP-binding protein	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00020	FAS signaling pathway	P00601	c-Jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ORYSJ|Gene=Os01g0866100|UniProtKB=P0C540	Actin-7	IC	14684598	PubMed	PTHR11937:SF205	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00466	EGFR	MOUSE|MGI=MGI=104771|UniProtKB=Q61527	Receptor tyrosine-protein kinase erbB-4	ISS	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00018	EGF receptor signaling pathway	P00551	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IGI	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00311	GCKR	RAT|RGD=1562028|UniProtKB=D3ZHL6	Mitogen-activated protein kinase kinase kinase kinase	ISS			PTHR24361:SF324	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 5
P00005	Angiogenesis	P00193	SOS-1	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MACMU|Ensembl=ENSMMUG00000012054|UniProtKB=F6TII3	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00034	Integrin signalling pathway	P00944	Actin	MONDO|Ensembl=ENSMODG00000000365|UniProtKB=F6R9F4	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	BOVIN|Ensembl=ENSBTAG00000020756|UniProtKB=A6QLB8	GSK3A protein	ISS	14698990	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MOUSE|MGI=MGI=1339709|UniProtKB=P13541	Myosin-3	ISS	10938134	PubMed	PTHR13140:SF427	MYOSIN-3
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00036	Interleukin signaling pathway	P00965	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	IC	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05915	Opioid proenkephalin pathway	P05994	G-protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00539	14-3-3	BOVIN|Ensembl=ENSBTAG00000005664|UniProtKB=P62261	14-3-3 protein epsilon	ISS	98119747	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P04395	Vasopressin synthesis	P04596	Endo Peptidase	PANTR|Ensembl=ENSPTRG00000018456|UniProtKB=H2QTH0	Prolyl endopeptidase	ISS	9695945	PubMed	PTHR42881:SF2	PROLYL ENDOPEPTIDASE
P00057	Wnt signaling pathway	P01444	Wnt	CHICK|Gene=WNT8C|UniProtKB=P51030	Protein Wnt-8c	IDA	8717036	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P00006	Apoptosis signaling pathway	P00297	NFkappaB	MACMU|Ensembl=ENSMMUG00000002990|UniProtKB=F7GVV0	Uncharacterized protein	ISS	12574369	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000003399|UniProtKB=H2Q383	Phosphoinositide-3-kinase, class 2, alpha polypeptide	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	CANLF|Ensembl=ENSCAFG00000011933|UniProtKB=F6UXI8	Inosine-5'-monophosphate dehydrogenase	ISS			PTHR11911:SF121	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04568	MKK3/6	MONDO|Ensembl=ENSMODG00000001404|UniProtKB=F7BD74	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00029	Huntington disease	P00786	ARF	DICPU|Gene=DICPUDRAFT_93077|UniProtKB=F1A1N6	ADP-ribosylation factor 1	ISS	11752622	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P04393	Ras Pathway	P04557	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00049	Parkinson disease	P01238	14-3-3	CANLF|Ensembl=ENSCAFG00000000580|UniProtKB=F1PBL1	Uncharacterized protein	ISS	92362864	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00029	Huntington disease	P00795	BDNF	PANTR|Ensembl=ENSPTRG00000028696|UniProtKB=Q5IS78	Brain-derived neurotrophic factor	ISS	11724916	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	ANOGA|EnsemblGenome=AGAP007120|UniProtKB=Q7QIX6	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P04398	p53 pathway feedback loops 2	P04662	cyclin G	RAT|RGD=2295|UniProtKB=P39950	Cyclin-G1	ISS	11983168	PubMed	PTHR10177:SF59	CYCLIN-G1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	CHICK|Gene_ORFName=RCJMB04_10k21|UniProtKB=Q5ZKI0	Calcium/calmodulin-dependent protein kinase type II delta chain	ISS	12888804	PubMed	PTHR43940:SF4	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT DELTA
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	IC	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	12464394	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00001	Adrenaline and noradrenaline biosynthesis	P00061	PNMT	XENTR|Ensembl=ENSXETG00000012652|UniProtKB=F7BI54	Uncharacterized protein	ISS			PTHR10867:SF19	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	MOUSE|MGI=MGI=106677|UniProtKB=Q8BRU6	Synaptic vesicular amine transporter	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P02724	Alanine biosynthesis	P02815	Branched chain amino acid aminotransferase	PANTR|Ensembl=ENSPTRG00000004772|UniProtKB=H2Q5L8	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF51	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, CYTOSOLIC
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00048	PI3 kinase pathway	P01190	PDK1 ACT	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00005	Angiogenesis	P00236	PI3K	XENTR|Xenbase=XB-GENE-6067221|UniProtKB=F6Z0J4	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00029	Huntington disease	P00795	BDNF	HUMAN|HGNC=1033|UniProtKB=P23560	Brain-derived neurotrophic factor	ISS	12117585	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00018	EGF receptor signaling pathway	P00547	PP2A	PANTR|Ensembl=ENSPTRG00000006734|UniProtKB=H2Q8X8	Uncharacterized protein	ISS	8576224	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	RAT|RGD=2740|UniProtKB=Q62645	Glutamate receptor ionotropic, NMDA 2D	ISS	11319238	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00054	Toll receptor signaling pathway	P01375	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00036	Interleukin signaling pathway	P00972	MNK1/2	RAT|RGD=1559603|UniProtKB=Q4G050	MAP kinase-interacting serine/threonine-protein kinase 1	ISS	97299868	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	STRCO|Gene=CAA19895|UniProtKB=O86742	Aldehyde dehydrogenase	IC	14724059	PubMed	PTHR11699:SF109	GAMMA-AMINOBUTYRALDEHYDE DEHYDROGENASE
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	ARATH|TAIR=AT1G16710|UniProtKB=Q9FWQ5	Histone acetyltransferase HAC12	TAS	10769018	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00014	Cholesterol biosynthesis	P00499	Farnesyl-diphosphate farnesyltransferase	MACMU|Ensembl=ENSMMUG00000019211|UniProtKB=F6QQ79	Squalene synthase	ISS			PTHR11626:SF2	SQUALENE SYNTHASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	ARATH|TAIR=AT5G19010|UniProtKB=Q8W4J2	Mitogen-activated protein kinase 16	ISS			PTHR24055:SF211	MITOGEN-ACTIVATED PROTEIN KINASE 16
P02776	Serine glycine biosynthesis	P03160	Phosphoglycerate dehydrogenase	ARATH|TAIR=AT3G19480|UniProtKB=Q9LT69	D-3-phosphoglycerate dehydrogenase 3, chloroplastic	ISS			PTHR42938:SF14	D-3-PHOSPHOGLYCERATE DEHYDROGENASE 1, CHLOROPLASTIC-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	CHICK|Ensembl=ENSGALG00000009405|UniProtKB=F1NKF1	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04393	Ras Pathway	P04570	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05915	Opioid proenkephalin pathway	P05993	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	PANTR|Ensembl=ENSPTRG00000015241|UniProtKB=Q5IS72	D(3) dopamine receptor	ISS	11861492	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	DANRE|ZFIN=ZDB-GENE-020125-3|UniProtKB=E7F1V8	Uncharacterized protein	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00034	Integrin signalling pathway	P00944	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g169611|UniProtKB=A7SEB1	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00005	Angiogenesis	P00243	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	G04690	PAG608	MOUSE|MGI=MGI=1195270|UniProtKB=O54836	Zinc finger matrin-type protein 3	IDA	9250682	PubMed	PTHR23067:SF5	ZINC FINGER MATRIN-TYPE PROTEIN 3
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00049	Parkinson disease	P01242	Casein kinase I	ORYSJ|Gene=Os01g0198200|UniProtKB=Q5QMY9	Os01g0198200 protein	IDA	10617630	PubMed	PTHR11909:SF288	SUBFAMILY NOT NAMED
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	RCA	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00057	Wnt signaling pathway	P01434	sFRP	RAT|RGD=735163|UniProtKB=B1WBV2	Protein Sfrp2	ISS	9096311	PubMed	PTHR11309:SF45	SECRETED FRIZZLED-RELATED PROTEIN 2
P02783	Tryptophan biosynthesis	P03206	Anthranilate synthase	ECOLI|EcoGene=EG10682|UniProtKB=P00903	Aminodeoxychorismate synthase component 2	RCA			PTHR43418:SF4	MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN
P00006	Apoptosis signaling pathway	P00302	ATF	RAT|RGD=620218|UniProtKB=P15337	Cyclic AMP-responsive element-binding protein 1	ISS	11390664	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00049	Parkinson disease	P01208	Hsp70	ARATH|TAIR=AT4G37910|UniProtKB=Q8GUM2	Heat shock 70 kDa protein 9, mitochondrial	IDA	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00052	TGF-beta signaling pathway	P01275	P38	TAKRU|Ensembl=ENSTRUG00000008723|UniProtKB=H2TB66	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF331	SUBFAMILY NOT NAMED
P00010	B cell activation	P00379	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00029	Huntington disease	P00807	Actin	XENTR|Xenbase=XB-GENE-491938|UniProtKB=Q6DIV8	Actin, alpha 1, skeletal muscle	ISS	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IDA	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000009594|UniProtKB=G2HFH4	Somatostatin receptor type 2	ISS	12441358	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P04393	Ras Pathway	P04547	Ras	MOUSE|MGI=MGI=96680|UniProtKB=P32883	GTPase KRas	IDA	6287573	PubMed	PTHR24070:SF186	GTPASE KRAS
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P06664	Gonadotropin-releasing hormone receptor pathway	P06831	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	RCA	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	TAS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	RAT|RGD=1311191|UniProtKB=D3ZN51	Protein Itga9	ISS	3487386	PubMed	PTHR23220:SF69	INTEGRIN ALPHA-9
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	MONDO|Ensembl=ENSMODG00000020977|UniProtKB=F6S5B1	Uncharacterized protein (Fragment)	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00807	Actin	TRYB2|Gene=Tb09.211.0620|UniProtKB=Q38E94	Actin A	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01072	CHT1	PANTR|Ensembl=ENSPTRG00000012325|UniProtKB=H2QII0	Uncharacterized protein	ISS	12675135	PubMed	PTHR11819:SF129	HIGH AFFINITY CHOLINE TRANSPORTER 1
P00015	Circadian clock system	P00502	Casein kinase I	DANRE|ZFIN=ZDB-GENE-040426-2385|UniProtKB=Q6P3K7	Casein kinase I isoform delta-B	ISS	11437445	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P04397	p53 pathway by glucose deprivation	P04636	S6K	ORNAN|Ensembl=ENSOANG00000002226|UniProtKB=F6TPX7	Ribosomal protein S6 kinase	ISS	15116068	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00035	Interferon-gamma signaling pathway	P00961	STAT1	DANRE|ZFIN=ZDB-GENE-980526-499|UniProtKB=Q6P943	Signal transducer and activator of transcription	TAS	10417824	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00029	Huntington disease	P00775	Rac	PHANO|EnsemblGenome=SNOG_12991|UniProtKB=Q0U5H3	Uncharacterized protein	ISS			PTHR24072:SF192	CDC42 HOMOLOG
P00048	PI3 kinase pathway	P01203	p101	HUMAN|HGNC=30035|UniProtKB=Q8WYR1	Phosphoinositide 3-kinase regulatory subunit 5	IGI	129387	gi	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00034	Integrin signalling pathway	P00931	Integrin beta	XENTR|Xenbase=XB-GENE-946725|UniProtKB=Q6P4X1	Integrin beta	ISS	3487386	PubMed	PTHR10082:SF28	INTEGRIN BETA-1
P00029	Huntington disease	P00811	Arp2/3 complex	RAT|RGD=1311791|UniProtKB=Q4KLF8	Actin-related protein 2/3 complex subunit 5	ISS	12932731	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P04393	Ras Pathway	P04570	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01294	NFAT	BOVIN|Ensembl=ENSBTAG00000018270|UniProtKB=F1MGR9	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00034	Integrin signalling pathway	P00925	MEK	MOUSE|MGI=MGI=1346868|UniProtKB=O09110	Dual specificity mitogen-activated protein kinase kinase 3	IDA	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00018	EGF receptor signaling pathway	P00545	JNK1-3	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04568	MKK3/6	CHICK|Ensembl=ENSGALG00000004735|UniProtKB=F1NHE1	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00006	Apoptosis signaling pathway	P00269	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01200	SHIP	CANLF|Ensembl=ENSCAFG00000005743|UniProtKB=F1PNY0	Uncharacterized protein	ISS	9824312	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00052	TGF-beta signaling pathway	P01286	TGFbeta	CHICK|Gene=TGFB2|UniProtKB=P30371	Transforming growth factor beta-2	TAS	9759503	PubMed	PTHR11848:SF141	TRANSFORMING GROWTH FACTOR BETA-2
P00059	p53 pathway	G04694	p110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01177	P110ACT	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01304	Csk	BOVIN|Ensembl=ENSBTAG00000021424|UniProtKB=Q0VBZ0	Tyrosine-protein kinase CSK	ISS	7687537	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00004	Alzheimer disease-presenilin pathway	P00134	Nectin 1alpha transmembrane fragment	BOVIN|Ensembl=ENSBTAG00000015939|UniProtKB=F1MQJ3	Uncharacterized protein	ISS	12376527	PubMed	PTHR23277:SF69	NECTIN-1
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	RAT|RGD=2343|UniProtKB=P08483	Muscarinic acetylcholine receptor M3	ISS	12181435	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00006	Apoptosis signaling pathway	P00318	PKCs	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00029	Huntington disease	P00790	beta-Tubulin	HUMAN|HGNC=12412|UniProtKB=Q13885	Tubulin beta-2A chain	TAS	9454836	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P00045	Notch signaling pathway	P01113	Pen-2	XENTR|Xenbase=XB-GENE-854877|UniProtKB=F7C949	Presenilin	ISS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	8920915	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P05731	GABA-B receptor II signaling	P05756	GABA-B receptor	RAT|RGD=619864|UniProtKB=O88871	Gamma-aminobutyric acid type B receptor subunit 2	RCA			PTHR10519:SF62	GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CANLF|Ensembl=ENSCAFG00000009672|UniProtKB=E2RDT2	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00005	Angiogenesis	P00206	Wnt	MOUSE|MGI=MGI=98953|UniProtKB=P04426	Proto-oncogene Wnt-1	ISS	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00010	B cell activation	P00373	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	HUMAN|HGNC=1959|UniProtKB=P30532	Neuronal acetylcholine receptor subunit alpha-5	IC	85270494	PubMed	PTHR18945:SF76	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	TAKRU|Ensembl=ENSTRUG00000016241|UniProtKB=H2UX35	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF305	PROTEIN KINASE C
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00049	Parkinson disease	P01233	Elk-1	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	11279280	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00010	B cell activation	P00385	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	10891487	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	ARATH|TAIR=AT5G58700|UniProtKB=Q944C1	Phosphoinositide phospholipase C 4	TAS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P05913	Enkephalin release	P05973	GPCR (i)	RAT|RGD=3233|UniProtKB=P33533	Delta-type opioid receptor	ISS	11259498	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00044	Nicotinic acetylcholine receptor signaling pathway	P01093	AChE	DANRE|ZFIN=ZDB-GENE-010906-1|UniProtKB=Q9DDE3	Acetylcholinesterase	ISS	86008285	PubMed	PTHR43918:SF3	ACETYLCHOLINESTERASE
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	11790551	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00036	Interleukin signaling pathway	P00976	GSK3	STRPU|EnsemblGenome=SPU_009263|UniProtKB=W4Y0P1	Uncharacterized protein	ISS	9609832	PubMed	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	PANTR|Ensembl=ENSPTRG00000023608|UniProtKB=H2QZZ2	Uncharacterized protein	ISS	11554554	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00019	Endothelin signaling pathway	P00590	IP3 R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	TAS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	HUMAN|HGNC=144|UniProtKB=P63261	Actin, cytoplasmic 2	IC	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00048	PI3 kinase pathway	P01202	p85	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00021	FGF signaling pathway	P00628	JNK1-3	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IGI	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00056	VEGF signaling pathway	P01408	Akt/PKB	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00632	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00022	General transcription by RNA polymerase I	P00657	TBP	TETTS|EnsemblGenome=TTHERM_00575350|UniProtKB=Q22V65	TATA box-binding protein (TBP): present in archaea and protein	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	TAS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00049	Parkinson disease	P01238	14-3-3	SCHMA|EnsemblGenome=Smp_002410|UniProtKB=Q95W36	14-3-3 epsilon 2	IDA	22057984	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00018	EGF receptor signaling pathway	P00555	MKK4,7	HUMAN|HGNC=6844|UniProtKB=P45985	Dual specificity mitogen-activated protein kinase kinase 4	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	RAT|RGD=628850|UniProtKB=B1WBR9	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00047	PDGF signaling pathway	P01154	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	P01446	Calcineurin	MACMU|Ensembl=ENSMMUG00000015714|UniProtKB=F6SFE0	Serine/threonine-protein phosphatase	ISS	7532676	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00203	Erk	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CANLF|Ensembl=ENSCAFG00000013148|UniProtKB=Q5R1P3	Glutamate receptor ionotropic, NMDA 2B	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	HUMAN|HGNC=2509|UniProtKB=P35221	Catenin alpha-1	TAS	9362521	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00021	FGF signaling pathway	P00627	ERK1-2	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05734	Synaptic vesicle trafficking	P05778	SNAP-25	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	RCA			PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00037	Ionotropic glutamate receptor pathway	P01020	NSF	MACMU|Ensembl=ENSMMUG00000005548|UniProtKB=F6YT14	Uncharacterized protein	ISS	7969419	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00049	Parkinson disease	P01235	Fyn kinase	CANLF|Ensembl=ENSCAFG00000003995|UniProtKB=E2RC09	Tyrosine-protein kinase	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00050	Plasminogen activating cascade	P01245	PAI-1	PANTR|Ensembl=ENSPTRG00000019519|UniProtKB=H2QV47	Uncharacterized protein	ISS	189578	gi	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00025	Hedgehog signaling pathway	P00682	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00058	mRNA splicing	P01475	U2AF65	PANTR|Ensembl=ENSPTRG00000017138|UniProtKB=H2QRB8	Uncharacterized protein	ISS			PTHR12620:SF29	U2 SMALL NUCLEAR RIBONUCLEOPROTEIN AUXILIARY FACTOR 35 KDA SUBUNIT-RELATED PROTEIN 1
P00049	Parkinson disease	P01211	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01275	P38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00636	FGFR1-4	PANTR|Ensembl=ENSPTRG00000015836|UniProtKB=H2QP39	Fibroblast growth factor receptor	ISS	14520460	PubMed	PTHR24416:SF505	FIBROBLAST GROWTH FACTOR RECEPTOR 3
P00010	B cell activation	P00381	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00020	FAS signaling pathway	P00599	Caspase3	DANRE|ZFIN=ZDB-GENE-011210-1|UniProtKB=B8JK21	Uncharacterized protein	IGI	9323209	PubMed	PTHR10454:SF198	CASPASE-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	PANTR|Ensembl=ENSPTRG00000022187|UniProtKB=Q7YQL4	Serine/threonine-protein kinase PAK 3	ISS	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00010	B cell activation	P00375	Calmodulin	BOVIN|Ensembl=ENSBTAG00000014583|UniProtKB=P62157	Calmodulin	ISS	3885394	PubMed	PTHR23050:SF335	CALMODULIN, STRIATED MUSCLE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	ARATH|TAIR=AT3G58160|UniProtKB=Q9M2K0	Myosin-16	IC			PTHR13140:SF652	MYOSIN-16
P02721	ATP synthesis	P02796	F1 gamma	ECOLI|EcoGene=EG10104|UniProtKB=P0ABA6	ATP synthase gamma chain	ISS	6625702	gi	PTHR11693:SF22	ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P04609	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MOUSE|MGI=MGI=1098434|UniProtKB=O08850	Regulator of G-protein signaling 5	IDA	8756726	PubMed	PTHR10845:SF42	REGULATOR OF G-PROTEIN SIGNALING 5
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	ORNAN|Gene=WNT2|UniProtKB=Q07DZ8	Protein Wnt-2	ISS	8717036	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	89186920	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00010	B cell activation	P00379	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MOUSE|MGI=MGI=1923959|UniProtKB=Q9CVB6	Actin-related protein 2/3 complex subunit 2	ISS	12473693	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MONDO|Ensembl=ENSMODG00000004799|UniProtKB=F6VM87	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00036	Interleukin signaling pathway	P00977	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00029	Huntington disease	P00780	Microtubule	RAT|RGD=1305887|UniProtKB=Q4QQV0	Protein Tubb6	IDA	9454836	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00010	B cell activation	P00391	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00021	FGF signaling pathway	P00629	PP2A	STRPU|EnsemblGenome=SPU_025182|UniProtKB=W4ZAK5	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00790	beta-Tubulin	TRIAD|EnsemblGenome=TriadG63686|UniProtKB=B3RQ31	Beta-tubulin	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00012	Cadherin signaling pathway	P00475	Frizzled	DANRE|ZFIN=ZDB-GENE-000328-3|UniProtKB=Q9YI00	Frizzled 8a protein	IDA	8717036	PubMed	PTHR11309:SF90	FRIZZLED-8
P00025	Hedgehog signaling pathway	P00687	Cubitus interruptus repressor	HUMAN|HGNC=4319|UniProtKB=P10071	Transcriptional activator GLI3	IDA	15994174	PubMed	PTHR19818:SF5	TRANSCRIPTIONAL ACTIVATOR GLI3
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00009	Axon guidance mediated by netrin	P00364	cdc42	HUMAN|HGNC=1736|UniProtKB=P60953	Cell division control protein 42 homolog	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00029	Huntington disease	P00786	ARF	RAT|RGD=621273|UniProtKB=P61206	ADP-ribosylation factor 3	ISS	12932731	PubMed	PTHR11711:SF294	ADP-RIBOSYLATION FACTOR 3
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	ISS	96149441	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	BOVIN|Ensembl=ENSBTAG00000008783|UniProtKB=E1BD86	Uncharacterized protein	ISS	12441358	PubMed	PTHR24247:SF116	5-HYDROXYTRYPTAMINE RECEPTOR 7
P00019	Endothelin signaling pathway	P00570	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P05913	Enkephalin release	P05977	G-Protein (s)	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	PANTR|Ensembl=ENSPTRG00000017042|UniProtKB=H2QR61	Dihydrofolate reductase	ISS			PTHR22778:SF39	DIHYDROFOLATE REDUCTASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IDA	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	P17325	SPACC	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MOUSE|MGI=MGI=1855688|UniProtKB=O88384	Vesicle transport through interaction with t-SNAREs homolog 1B	ISS	14570579	PubMed	PTHR21230:SF26	VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1B
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06834	MAP3Ks	MOUSE|MGI=MGI=1858204|UniProtKB=Q9WUL6	Mitogen-activated protein kinase kinase kinase 14	RCA			PTHR24361:SF226	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 14
P00050	Plasminogen activating cascade	P01246	Plasmin	MOUSE|MGI=MGI=97620|UniProtKB=P20918	Plasminogen	ISS	15928602	gi	PTHR24261:SF5	PLASMINOGEN
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00036	Interleukin signaling pathway	P00970	Interleukin	MACMU|Ensembl=ENSMMUG00000003346|UniProtKB=F7EGQ8	Interleukin	ISS	11081504	PubMed	PTHR14356:SF2	INTERLEUKIN-21
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	DROME|FlyBase=FBgn0000259|UniProtKB=P08182	Casein kinase II subunit beta	IDA	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00023	General transcription regulation	P00668	TFIIB	XENTR|Xenbase=XB-GENE-494448|UniProtKB=L7N3H9	Uncharacterized protein (Fragment)	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P00034	Integrin signalling pathway	P00920	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IPI	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P02743	Formyltetrahydroformate biosynthesis	P02954	Thymidylate synthase	ARATH|TAIR=AT2G16370|UniProtKB=Q05762	Bifunctional dihydrofolate reductase-thymidylate synthase 1	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00047	PDGF signaling pathway	P01162	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01224	UbcH7	MACMU|Ensembl=ENSMMUG00000004096|UniProtKB=F6ZC17	Uncharacterized protein	ISS	10888878	PubMed	PTHR24068:SF67	UBIQUITIN-CONJUGATING ENZYME E2 L3
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00059	p53 pathway	G04694	p110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IDA	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00200	Dsh	HUMAN|HGNC=3084|UniProtKB=O14640	Segment polarity protein dishevelled homolog DVL-1	IDA	7906389	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=7599|UniProtKB=Q12965	Unconventional myosin-Ie	IC			PTHR13140:SF341	UNCONVENTIONAL MYOSIN-IE
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	MONDO|Ensembl=ENSMODG00000002847|UniProtKB=F7B627	Uncharacterized protein (Fragment)	ISS	11907044	PubMed	PTHR44025:SF7	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IGI	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00036	Interleukin signaling pathway	P00990	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000010392|UniProtKB=F7ASR8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00010	B cell activation	P00367	NFAT	HUMAN|HGNC=7776|UniProtKB=Q13469	Nuclear factor of activated T-cells, cytoplasmic 2	IDA	9462517	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	BOVIN|Ensembl=ENSBTAG00000011339|UniProtKB=A7MAZ4	Transcription initiation factor TFIID subunit 8	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00060	Ubiquitin proteasome pathway	P01491	E2	XENTR|Xenbase=XB-GENE-971108|UniProtKB=F7CZ16	Uncharacterized protein	ISS			PTHR44189:SF1	UBIQUITIN-CONJUGATING ENZYME E2 C
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	MOUSE|MGI=MGI=894315|UniProtKB=Q99JI6	Ras-related protein Rap-1b	ISS	1904317	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P05731	GABA-B receptor II signaling	P05760	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P02721	ATP synthesis	P02794	F1 beta	RAT|RGD=621368|UniProtKB=P10719	ATP synthase subunit beta, mitochondrial	ISS	2896550	PubMed	PTHR15184:SF44	ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL
P00010	B cell activation	P00384	p38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00005	Angiogenesis	P00236	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00062	TH	MOUSE|MGI=MGI=98735|UniProtKB=P24529	Tyrosine 3-monooxygenase	ISS	12814656	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04546	GSK3	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	IDA	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05912	Dopamine receptor mediated signaling pathway	P05963	MAO	MACMU|Ensembl=ENSMMUG00000019492|UniProtKB=F7D3H3	Amine oxidase [flavin-containing]	ISS	90344230	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00007	Axon guidance mediated by semaphorins	P00339	CRMP	MONDO|Ensembl=ENSMODG00000016680|UniProtKB=F7DMI7	Uncharacterized protein	ISS	7637782	PubMed	PTHR11647:SF56	DIHYDROPYRIMIDINASE-RELATED PROTEIN 2
P00019	Endothelin signaling pathway	P00586	Gq	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P06959	CCKR signaling map	P07210	BAD	HUMAN|HGNC=936|UniProtKB=Q92934	Bcl2-associated agonist of cell death	RCA	10611223	PubMed	PTHR28540:SF1	BCL2-ASSOCIATED AGONIST OF CELL DEATH
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00050	Plasminogen activating cascade	P01253	Fibrin	BOVIN|Gene=FGG|UniProtKB=P12799	Fibrinogen gamma-B chain	ISS	89366676	PubMed	PTHR19143:SF338	FIBRINOGEN GAMMA CHAIN
P00056	VEGF signaling pathway	P01423	p38MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MOUSE|MGI=MGI=95819|UniProtKB=P35438	Glutamate receptor ionotropic, NMDA 1	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00718	Phosphorylase a	PANTR|Ensembl=ENSPTRG00000006337|UniProtKB=H2Q8A4	Alpha-1,4 glucan phosphorylase	ISS	4318782	PubMed	PTHR11468:SF12	GLYCOGEN PHOSPHORYLASE, LIVER FORM
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	RAT|RGD=621005|UniProtKB=Q08849	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00021	FGF signaling pathway	P00624	14-3-3	HUMAN|HGNC=12851|UniProtKB=P62258	14-3-3 protein epsilon	ISS	98119747	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00005	Angiogenesis	P00243	Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	ISS	12068308	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P04393	Ras Pathway	P04543	MEKK1/4	PANTR|Ensembl=ENSPTRG00000016891|UniProtKB=H2R5K3	Uncharacterized protein	ISS	8940199	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00054	Toll receptor signaling pathway	P01342	IRAK4	CANLF|Ensembl=ENSCAFG00000009700|UniProtKB=E2RDL0	Uncharacterized protein	ISS			PTHR24419:SF22	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MOUSE|MGI=MGI=1346868|UniProtKB=O09110	Dual specificity mitogen-activated protein kinase kinase 3	IC	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	TAS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01181	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	DANRE|ZFIN=ZDB-GENE-030513-3|UniProtKB=B3DJU0	Thyroid stimulating hormone, beta subunit	ISS	15927770	PubMed	PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00623	FGF	MOUSE|MGI=MGI=95515|UniProtKB=P61148	Fibroblast growth factor 1	IGI	12095987	PubMed	PTHR11486:SF86	FIBROBLAST GROWTH FACTOR 1
P00057	Wnt signaling pathway	P01444	Wnt	TAKRU|Ensembl=ENSTRUG00000007912|UniProtKB=H2T4W3	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF83	PROTEIN WNT
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	IC	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00034	Integrin signalling pathway	P00944	Actin	ORNAN|Ensembl=ENSOANG00000007581|UniProtKB=F6QWB7	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00059	p53 pathway	P01480	PTEN	TAKRU|Ensembl=ENSTRUG00000009851|UniProtKB=H2TJ90	Uncharacterized protein	IGI	21455682	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P06664	Gonadotropin-releasing hormone receptor pathway	P06849	Sos	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	RCA	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00034	Integrin signalling pathway	P00923	Arf1	BOVIN|Ensembl=ENSBTAG00000011883|UniProtKB=Q2YDM1	ADP-ribosylation factor-like protein 1	ISS	11752622	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P00018	EGF receptor signaling pathway	P00545	JNK1-3	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P02785	Valine biosynthesis	P03215	Branched chain amino acid aminotransferase	MOUSE|MGI=MGI=1276534|UniProtKB=O35855	Branched-chain-amino-acid aminotransferase, mitochondrial	ISS			PTHR11825:SF39	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, MITOCHONDRIAL
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=12783|UniProtKB=P56705	Protein Wnt-4	TAS	8717036	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00029	Huntington disease	P00790	beta-Tubulin	RAT|RGD=1309427|UniProtKB=Q3KRE8	Tubulin beta-2B chain	TAS	12932731	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00011	Blood coagulation	P00458	GP IIIa	HUMAN|Ensembl=ENSG00000259753|UniProtKB=H3BM21	Integrin beta (Fragment)	ISS	280842	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00012	Cadherin signaling pathway	P00467	alpha-catenin	HUMAN|HGNC=2509|UniProtKB=P35221	Catenin alpha-1	ISS	1768802	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00932	FAK	MONDO|Ensembl=ENSMODG00000000707|UniProtKB=F6WLE6	Uncharacterized protein	ISS	9182576	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00047	PDGF signaling pathway	P01162	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00034	Integrin signalling pathway	P00906	Rap1	BOVIN|Ensembl=ENSBTAG00000014710|UniProtKB=P62833	Ras-related protein Rap-1A	ISS	1904317	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P05915	Opioid proenkephalin pathway	P05994	G-protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	PANTR|Ensembl=ENSPTRG00000009554|UniProtKB=H2QDP9	Uncharacterized protein	ISS	12356903	PubMed	PTHR10845:SF103	AXIN-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IDA	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00049	Parkinson disease	P01236	Casein kinase II	ARATH|TAIR=AT4G17640|UniProtKB=P40229	Casein kinase II subunit beta'	IDA	10617630	PubMed	PTHR11740:SF15	CASEIN KINASE II SUBUNIT BETA-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	ORNAN|Ensembl=ENSOANG00000013961|UniProtKB=F6VPY1	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ARATH|TAIR=AT3G46520|UniProtKB=P53497	Actin-12	IC	14684598	PubMed	PTHR11937:SF276	ACTIN-12
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P06664	Gonadotropin-releasing hormone receptor pathway	P06852	nPKCs	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00009	Axon guidance mediated by netrin	P00363	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	8838325	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00049	Parkinson disease	P01215	Syntaxin	ARATH|TAIR=AT5G16830|UniProtKB=Q39233	Syntaxin-21	IPI			PTHR19957:SF38	T-SNARE DOMAIN-CONTAINING PROTEIN 1
P00034	Integrin signalling pathway	P00922	Collagen	MOUSE|MGI=MGI=88448|UniProtKB=Q60847	Collagen alpha-1(XII) chain	IDA	10778855	PubMed	PTHR45047:SF2	COLLAGEN ALPHA-1 XII  CHAIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00018	EGF receptor signaling pathway	P00551	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01232	CASK	TAKRU|Ensembl=ENSTRUG00000011655|UniProtKB=H2TXP5	Uncharacterized protein	ISS	11430913	PubMed	PTHR23122:SF40	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MONDO|Ensembl=ENSMODG00000001404|UniProtKB=F7BD74	Uncharacterized protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00009	Axon guidance mediated by netrin	P00366	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00047	PDGF signaling pathway	P01160	IP3 receptor	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000012822|UniProtKB=F6PX40	Phosphoinositide phospholipase C	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00038	JAK/STAT signaling pathway	P01033	PTP	TAKRU|Ensembl=ENSTRUG00000002498|UniProtKB=H2S070	Uncharacterized protein (Fragment)	ISS			PTHR19134:SF284	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C
P00006	Apoptosis signaling pathway	P00327	FADD	PANTR|Ensembl=ENSPTRG00000004004|UniProtKB=H2Q4B6	FAS-associated death domain protein	ISS	7538907	PubMed	PTHR15077:SF8	FAS-ASSOCIATED DEATH DOMAIN PROTEIN
P00018	EGF receptor signaling pathway	P00545	JNK1-3	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00029	Huntington disease	P00787	MAPKK4	MONDO|Ensembl=ENSMODG00000008266|UniProtKB=F6Z879	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00048	PI3 kinase pathway	P01179	PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	IC	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00047	PDGF signaling pathway	P01175	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	7798194	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00916	Ras	RAT|RGD=1311443|UniProtKB=D3Z8L7	Ras-related protein R-Ras	ISS	7997267	PubMed	PTHR24070:SF245	RAS-RELATED PROTEIN R-RAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Ensembl=ENSBTAG00000018989|UniProtKB=A5D7D8	GRM3 protein	ISS	12351712	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	TAS	95181376	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00223	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	CAEEL|WormBase=WBGene00001680|UniProtKB=Q20636	Guanine nucleotide-binding protein subunit beta-2	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	DROME|FlyBase=FBgn0020622|UniProtKB=Q7KTZ2	Pi3K21B, isoform B	ISS	7937853	PubMed	PTHR10155:SF0	PI3K21B, ISOFORM B
P02751	Lysine biosynthesis	P03008	Dihydrodipicolinate synthase	SYNY3|EnsemblGenome=BAA10870|UniProtKB=Q55513	4-hydroxy-tetrahydrodipicolinate synthase	ISS			PTHR12128:SF15	4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL
P00011	Blood coagulation	P00416	Prothrombin	RAT|RGD=61996|UniProtKB=P18292	Prothrombin	ISS	6753798	gi	PTHR24254:SF10	PROTHROMBIN
P00010	B cell activation	P00383	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00048	PI3 kinase pathway	P01179	PKB	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00474	Wnt	CANLF|Ensembl=ENSCAFG00000029321|UniProtKB=J9P5H0	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P05915	Opioid proenkephalin pathway	P05994	G-protein	ANOGA|EnsemblGenome=AGAP001506|UniProtKB=Q7PXP3	AGAP001506-PA	IC			PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00774	Dynein complex	PANTR|Ensembl=ENSPTRG00000016734|UniProtKB=H2QQN4	Uncharacterized protein	ISS	9454836	PubMed	PTHR10676:SF240	DYNEIN HEAVY CHAIN 5, AXONEMAL
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	BOVIN|Ensembl=ENSBTAG00000006675|UniProtKB=F1MCT1	Uncharacterized protein	ISS			PTHR42884:SF8	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 6
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	IC	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	TAKRU|Ensembl=ENSTRUG00000016954|UniProtKB=H2V2J5	Uncharacterized protein	ISS	15858232	PubMed	PTHR13715:SF99	SUBFAMILY NOT NAMED
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01142	p90RSK	MONDO|Ensembl=ENSMODG00000006241|UniProtKB=F7FRY0	Ribosomal protein S6 kinase	ISS	1922062	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00021	FGF signaling pathway	P00625	MKK3,6	ORNAN|Ensembl=ENSOANG00000007732|UniProtKB=F6PXH5	Uncharacterized protein (Fragment)	ISS	97059154	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00020	FAS signaling pathway	P00601	c-Jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00010	B cell activation	P00375	Calmodulin	CHICK|Gene_ORFName=RCJMB04_24e7|UniProtKB=P62149	Calmodulin	ISS	10487978	PubMed	PTHR23050:SF311	CALMODULIN
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04392	P53 pathway feedback loops 1	P04539	p53	CHICK|Ensembl=ENSGALG00000007324|UniProtKB=F1N8Z7	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00780	Microtubule	CHICK|Ensembl=ENSGALG00000027684|UniProtKB=P09653	Tubulin beta-5 chain	IDA	9454836	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00054	Toll receptor signaling pathway	P01367	MKK3	HUMAN|HGNC=6843|UniProtKB=P46734	Dual specificity mitogen-activated protein kinase kinase 3	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	SCHMA|EnsemblGenome=Smp_020170|UniProtKB=G4V8E3	Voltage-dependent calcium channel (Fragment)	ISS	14624853	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P00021	FGF signaling pathway	P00641	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00053	T cell activation	P01322	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00021	FGF signaling pathway	P00641	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IGI	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	IDA	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00021	FGF signaling pathway	P00648	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	IGI	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00005	Angiogenesis	P00223	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CANLF|Ensembl=ENSCAFG00000008653|UniProtKB=F1PE26	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00057	Wnt signaling pathway	P01465	Ggamma	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04393	Ras Pathway	P04563	Ets	MOUSE|MGI=MGI=95455|UniProtKB=P27577	Protein C-ets-1	ISS	15298723	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IDA	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	SCHPO|PomBase=SPAC8C9.03|UniProtKB=P36600	cAMP-dependent protein kinase regulatory subunit	ISS	176892	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000008430|UniProtKB=F6VB97	Uncharacterized protein	ISS			PTHR11824:SF8	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-3
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00010	B cell activation	P00386	Calcineurin	MACMU|Ensembl=ENSMMUG00000004599|UniProtKB=F6Q932	Serine/threonine-protein phosphatase	ISS	7532676	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00906	Rap1	CHICK|Ensembl=ENSGALG00000009927|UniProtKB=Q5ZHX1	Ras-related protein Rap-1b	ISS	8576107	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	BOVIN|Gene=PLCD4|UniProtKB=P21671	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	7822322	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00050	Plasminogen activating cascade	P01253	Fibrin	HUMAN|HGNC=3662|UniProtKB=P02675	Fibrinogen beta chain	IDA	223002	gi	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000007445|UniProtKB=F6SWI4	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PUCGT|EnsemblGenome=PGTG_05488|UniProtKB=E3K4I1	Actin	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02769	Purine metabolism	P03117	5'-AMP Deaminase	MONDO|Ensembl=ENSMODG00000008171|UniProtKB=F7E5A8	Uncharacterized protein	ISS	1420359	PubMed	PTHR11359:SF2	AMP DEAMINASE 3
P00036	Interleukin signaling pathway	P00983	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00020	FAS signaling pathway	P00615	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00029	Huntington disease	P00780	Microtubule	LEIMA|EnsemblGenome=LmjF.33.0792|UniProtKB=Q4Q4C4	Beta tubulin	IDA	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00049	Parkinson disease	P01211	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=1346069|UniProtKB=Q9Z0M3	Cadherin-20	IDA	8120095	PubMed	PTHR24027:SF84	CADHERIN-20
P02749	Leucine biosynthesis	P02999	2-Isopropylmalate synthase	NEUCR|EnsemblGenome=EFNCRG00000001117|UniProtKB=Q7SFM2	2-isopropylmalate synthase	ISS			PTHR10277:SF28	SUBFAMILY NOT NAMED
P00035	Interferon-gamma signaling pathway	P00953	Jak1	CANLF|Ensembl=ENSCAFG00000018615|UniProtKB=F1PIY7	Tyrosine-protein kinase	ISS	11929133	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01070	K+ channel	CHICK|Ensembl=ENSGALG00000005822|UniProtKB=E1C3B4	Uncharacterized protein	ISS	12165472	PubMed	PTHR11537:SF6	POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CHICK|Ensembl=ENSGALG00000004735|UniProtKB=F1NHE1	Uncharacterized protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	BOVIN|Gene=SLC18A2|UniProtKB=Q27963	Synaptic vesicular amine transporter	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CHLRE|EnsemblGenome=CHLREDRAFT_24392|UniProtKB=A8JAV1	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00054	Toll receptor signaling pathway	P01371	TRAF6	HUMAN|HGNC=12036|UniProtKB=Q9Y4K3	TNF receptor-associated factor 6	ISS			PTHR10131:SF111	TNF RECEPTOR-ASSOCIATED FACTOR 6
P00011	Blood coagulation	P00439	Prekallikrein	RAT|RGD=67382|UniProtKB=P14272	Plasma kallikrein	ISS	20072342	gi	PTHR44459:SF2	PLASMA KALLIKREIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	HUMAN|HGNC=708|UniProtKB=O15511	Actin-related protein 2/3 complex subunit 5	IDA	12473693	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P02761	Pantothenate biosynthesis	P03066	Aspartate decarboxylase	BACSU|EnsemblGenome=BSU22410|UniProtKB=P52999	Aspartate 1-decarboxylase	ISS			PTHR21012:SF0	ASPARTATE 1-DECARBOXYLASE
P00019	Endothelin signaling pathway	P00566	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	RCA			PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00029	Huntington disease	P00786	ARF	DANRE|ZFIN=ZDB-GENE-040718-175|UniProtKB=Q6DGK1	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P04373	5HT1 type receptor mediated signaling pathway	P04407	K+ channel	MONDO|Ensembl=ENSMODG00000015769|UniProtKB=F6ZSC2	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P04397	p53 pathway by glucose deprivation	P04641	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05760	AC	HUMAN|HGNC=235|UniProtKB=Q8NFM4	Adenylate cyclase type 4	ISS	2491850	PubMed	PTHR11920:SF286	ADENYLATE CYCLASE TYPE 4
P00034	Integrin signalling pathway	P00912	Arp2/3	BOVIN|Gene=ARPC5|UniProtKB=Q3SYX9	Actin-related protein 2/3 complex subunit 5	IPI	10322212	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DICDI|dictyBase=DDB_G0279413|UniProtKB=P05987	cAMP-dependent protein kinase regulatory subunit	IC	2372396	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00470	F-actin	MACMU|Ensembl=ENSMMUG00000007027|UniProtKB=F7F210	Alpha-cardiac actin	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00054	Toll receptor signaling pathway	P01357	MEKK1	PANTR|Ensembl=ENSPTRG00000016891|UniProtKB=H2R5K3	Uncharacterized protein	ISS	8940199	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P02751	Lysine biosynthesis	P03009	Aspartokinase	CHLTR|EnsemblGenome=CT_362|UniProtKB=O84367	Aspartokinase	ISS			PTHR21499:SF38	ASPARTOKINASE 1, CHLOROPLASTIC
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P02748	Isoleucine biosynthesis	P02997	Acetolactate synthase	SULSO|EnsemblGenome=SSO3210|UniProtKB=Q97U16	Acetolactate synthase large subunit homolog (IlvB-6)	ISS			PTHR18968:SF135	SUBFAMILY NOT NAMED
P00059	p53 pathway	P01480	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	MACMU|Ensembl=ENSMMUG00000023317|UniProtKB=F6Y514	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00046	Oxidative stress response	P01138	MKK4	MOUSE|MGI=MGI=1346875|UniProtKB=O08648	Mitogen-activated protein kinase kinase kinase 4	TAS	602425	OMIM	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00006	Apoptosis signaling pathway	P00269	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00255	Notch	HUMAN|HGNC=7882|UniProtKB=Q04721	Neurogenic locus notch homolog protein 2	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	CAEBR|Gene=CBG02401|UniProtKB=A8WUE7	Protein CBR-NMR-1	ISS	11554554	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00018	EGF receptor signaling pathway	P00560	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00018	EGF receptor signaling pathway	P00545	JNK1-3	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS			PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00019	Endothelin signaling pathway	P00566	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_94959|UniProtKB=C3XYC4	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P05918	p38 MAPK pathway	P05920	MAPKAP-K2	MOUSE|MGI=MGI=109298|UniProtKB=P49138	MAP kinase-activated protein kinase 2	RCA	8262198	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	CANAL|CGD=CAL0000192612|UniProtKB=P0CY33	Cell division control protein 42 homolog	ISS	4757952	gi	PTHR24072:SF192	CDC42 HOMOLOG
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00015	Circadian clock system	G01503	per	DROME|FlyBase=FBgn0003068|UniProtKB=P07663	Period circadian protein	IDA	574095	PubMed	PTHR11269:SF16	PERIOD CIRCADIAN PROTEIN
P00053	T cell activation	P01300	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000000289|UniProtKB=F7A9T0	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P04398	p53 pathway feedback loops 2	G04714	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00018	EGF receptor signaling pathway	P00554	Shc	PANTR|Ensembl=ENSPTRG00000021091|UniProtKB=H2QXF3	Uncharacterized protein	ISS	9507002	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	PANTR|Ensembl=ENSPTRG00000018449|UniProtKB=H2QTG5	Uncharacterized protein	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00057	Wnt signaling pathway	P01457	GBeta	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	188830	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00313	IKK	HUMAN|HGNC=1974|UniProtKB=O15111	Inhibitor of nuclear factor kappa-B kinase subunit alpha	IDA	12813046	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	YEAST|SGD=S000005738|UniProtKB=P18851	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04393	Ras Pathway	P04553	PAK	CHICK|Ensembl=ENSGALG00000000681|UniProtKB=E1C3P6	Uncharacterized protein	ISS	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00029	Huntington disease	P00796	Kainate receptor	ORNAN|Ensembl=ENSOANG00000002061|UniProtKB=F7ANC6	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00005	Angiogenesis	P00223	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	TAS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01415	MAPKAPK2/3	PANTR|Ensembl=ENSPTRG00000014968|UniProtKB=H2QMP5	Mitogen-activated protein kinase-activated protein kinase 3	ISS	11335727	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00053	T cell activation	P01318	PKC-theta	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IGI	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00034	Integrin signalling pathway	P00911	B-Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	ISS	12068308	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00015	Circadian clock system	P00502	Casein kinase I	XENTR|Xenbase=XB-GENE-481480|UniProtKB=Q5XGI6	Casein kinase 1, epsilon	ISS	11865049	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	BOVIN|Ensembl=ENSBTAG00000040329|UniProtKB=F1MMU1	Uncharacterized protein	ISS	12181435	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00017	DNA replication	P00534	PCNA	PYRAE|EnsemblGenome=PAE3038|UniProtKB=Q8ZTY0	DNA polymerase sliding clamp 1	ISS	21664397	PubMed	PTHR11352:SF0	PROLIFERATING CELL NUCLEAR ANTIGEN
P00019	Endothelin signaling pathway	P00568	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02749	Leucine biosynthesis	P03002	Isopropylmalate isomerase	SYNY3|EnsemblGenome=BAA18738|UniProtKB=P54384	3-isopropylmalate dehydratase large subunit	ISS			PTHR43822:SF2	HOMOACONITASE, MITOCHONDRIAL
P00013	Cell cycle	P00480	Proteasome	MACMU|Ensembl=ENSMMUG00000020382|UniProtKB=F6UFI7	26S proteasome non-ATPase regulatory subunit 3	ISS	2568889	PubMed	PTHR10758:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04570	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008422|UniProtKB=F6VUT7	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02751	Lysine biosynthesis	P03008	Dihydrodipicolinate synthase	PSEAE|EnsemblGenome=PA1254|UniProtKB=Q9I490	Probable dihydrodipicolinate synthetase	ISS			PTHR12128:SF35	SUBFAMILY NOT NAMED
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00048	PI3 kinase pathway	P01181	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IPI	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	RCA	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00010	B cell activation	P00398	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00019	Endothelin signaling pathway	P00571	Pro ET1-4	MACMU|Ensembl=ENSMMUG00000016214|UniProtKB=F7GJV6	Uncharacterized protein	ISS	12516960	PubMed	PTHR13874:SF9	ENDOTHELIN-2
P00029	Huntington disease	P00778	NMDA receptor	PANTR|Ensembl=ENSPTRG00000023608|UniProtKB=H2QZZ2	Uncharacterized protein	ISS	11319238	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00018	EGF receptor signaling pathway	P00552	Ras	DICPU|Gene=DICPUDRAFT_91367|UniProtKB=F0ZB76	Putative uncharacterized protein rasD	ISS	6091907	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00057	Wnt signaling pathway	P01438	PP2A	XENTR|Xenbase=XB-GENE-957248|UniProtKB=Q6GLE6	Serine/threonine-protein phosphatase	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	SCHPO|PomBase=SPAC18G6.04c|UniProtKB=Q10104	Serine hydroxymethyltransferase, mitochondrial	ISS			PTHR11680:SF21	SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MACMU|Ensembl=ENSMMUG00000010392|UniProtKB=F7ASR8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	XENTR|Xenbase=XB-GENE-982496|UniProtKB=F6Z8A1	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CHICK|Gene=CHRM3|UniProtKB=P49578	Muscarinic acetylcholine receptor M3	IDA	12181435	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00012	Cadherin signaling pathway	P00464	Fyn	MACMU|Ensembl=ENSMMUG00000017017|UniProtKB=F7FVL2	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	ARATH|TAIR=AT1G67220|UniProtKB=Q9FYH1	Histone acetyltransferase HAC2	TAS	8413673	PubMed	PTHR13808:SF6	HISTONE ACETYLTRANSFERASE HAC2
P04393	Ras Pathway	P04557	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IDA	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P02730	Asparagine and aspartate biosynthesis	P02853	Asparagine synthetase	BACSU|EnsemblGenome=BSU30540|UniProtKB=P54420	Asparagine synthetase [glutamine-hydrolyzing] 1	ISS			PTHR43284:SF2	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	RAT|RGD=620308|UniProtKB=P30936	Somatostatin receptor type 3	IDA			PTHR24229:SF42	SOMATOSTATIN RECEPTOR TYPE 3
P05918	p38 MAPK pathway	P06031	p38alpha	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	RCA	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01444	Wnt	DANRE|ZFIN=ZDB-GENE-980526-352|UniProtKB=P47793	Protein Wnt-4a	IDA	11266476	PubMed	PTHR12027:SF103	PROTEIN WNT-4A
P05731	GABA-B receptor II signaling	P05754	Ggamma	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	RCA	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	94313981	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00807	Actin	GIAIC|EnsemblGenome=GL50803_40817|UniProtKB=A8BV70	Actin related protein	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	P01438	PP2A	XENTR|Xenbase=XB-GENE-484003|UniProtKB=Q6P365	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00736	CalDAG-GEF	PANTR|Ensembl=ENSPTRG00000010930|UniProtKB=H2QG86	Uncharacterized protein	ISS	10835426	PubMed	PTHR23113:SF157	RAS GUANYL-RELEASING PROTEIN 4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P02738	De novo purine biosynthesis	P02902	ADP reductase	BOVIN|Ensembl=ENSBTAG00000008216|UniProtKB=E1BI58	Uncharacterized protein	ISS			PTHR23409:SF20	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	TAS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	SCHPO|PomBase=SPAC22G7.06c|UniProtKB=Q09794	Protein ura1	ISS			PTHR11405:SF5	CAD PROTEIN
P00018	EGF receptor signaling pathway	P00564	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	10891487	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00049	Parkinson disease	P01238	14-3-3	TAKRU|Ensembl=ENSTRUG00000004697|UniProtKB=H2SFG7	Uncharacterized protein	ISS	8381897	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	SCHPO|PomBase=SPAC3A12.05c|UniProtKB=P87121	Transcription initiation factor TFIID subunit 2	ISS			PTHR15137:SF9	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PHYPA|Gene=PHYPADRAFT_226658|UniProtKB=A9TYG3	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00056	VEGF signaling pathway	P01425	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	DROME|FlyBase=FBgn0011754|UniProtKB=Q9I7D0	GH22314p	IDA			PTHR44087:SF2	PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, LIVER/TESTIS ISOFORM
P00025	Hedgehog signaling pathway	P00691	CBP	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00019	Endothelin signaling pathway	P00590	IP3 R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CHICK|Ensembl=ENSGALG00000017238|UniProtKB=F1NWG3	Uncharacterized protein	IDA			PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_56687|UniProtKB=C3YC50	Putative uncharacterized protein	IC	3487386	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00036	Interleukin signaling pathway	P00976	GSK3	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00035	Interferon-gamma signaling pathway	P00956	SOCS	PANTR|Ensembl=ENSPTRG00000010105|UniProtKB=H2QEP3	Suppressor of cytokine signaling 6	ISS	15032587	PubMed	PTHR44562:SF1	SUPPRESSOR OF CYTOKINE SIGNALING 6
P00018	EGF receptor signaling pathway	P00561	STAT	ANOGA|EnsemblGenome=AGAP000099|UniProtKB=Q7QEQ3	Signal transducer and activator of transcription	ISS			PTHR11801:SF43	SIGNAL TRANSDUCER AND TRANSCRIPTION ACTIVATOR
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000009085|UniProtKB=H2RDQ2	Uncharacterized protein	ISS	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IDA	9860142	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00912	Arp2/3	CHICK|Ensembl=ENSGALG00000011452|UniProtKB=F1P1K3	Uncharacterized protein	ISS	12473693	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	YEAST|SGD=S000000028|UniProtKB=P31109	Synaptobrevin homolog 1	ISS	14570579	PubMed	PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00010	B cell activation	P00397	IKK	HUMAN|HGNC=1974|UniProtKB=O15111	Inhibitor of nuclear factor kappa-B kinase subunit alpha	IGI	9346484	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01465	Ggamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00036	Interleukin signaling pathway	P00970	Interleukin	BOVIN|Ensembl=ENSBTAG00000031235|UniProtKB=P52173	Interleukin-5	IC			PTHR45421:SF1	INTERLEUKIN-5
P00018	EGF receptor signaling pathway	P00560	Raf-1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P02746	Heme biosynthesis	P02973	Uroporphyrinogen methyltransferase	BACSU|EnsemblGenome=BSU03280|UniProtKB=P42437	Uroporphyrinogen-III C-methyltransferase	ISS			PTHR21091:SF138	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00907	ERK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS			PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	PANTR|Ensembl=ENSPTRG00000007084|UniProtKB=H2Q9G5	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BOVIN|Ensembl=ENSBTAG00000016012|UniProtKB=F1N5R1	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P00010	B cell activation	P00373	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00010	B cell activation	P00401	jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	8837781	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00007	Axon guidance mediated by semaphorins	P00340	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	10540223	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00059	p53 pathway	G04694	p110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01161	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MONDO|Ensembl=ENSMODG00000010644|UniProtKB=F7D4J8	Protein Wnt (Fragment)	ISS	11266476	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00019	Endothelin signaling pathway	P00585	ECE1-3	DROME|FlyBase=FBgn0037727|UniProtKB=Q9VH96	CG8358	ISS			PTHR11733:SF160	FI17316P1-RELATED
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=2136735|UniProtKB=Q91Y00	Protein Pcdhb2	IDA	8120095	PubMed	PTHR24028:SF77	PROTOCADHERIN BETA-2
P05731	GABA-B receptor II signaling	P05760	AC	HUMAN|HGNC=232|UniProtKB=Q08828	Adenylate cyclase type 1	ISS	89298382	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P00005	Angiogenesis	P00200	Dsh	HUMAN|HGNC=3086|UniProtKB=O14641	Segment polarity protein dishevelled homolog DVL-2	ISS	10409711	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P00048	PI3 kinase pathway	P01200	SHIP	CANLF|Ensembl=ENSCAFG00000005743|UniProtKB=F1PNY0	Uncharacterized protein	ISS	12145149	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00029	Huntington disease	P00790	beta-Tubulin	CHLRE|EnsemblGenome=CHLREDRAFT_129868|UniProtKB=A8IXZ0	Beta tubulin 1	TAS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	HUMAN|HGNC=4586|UniProtKB=Q13224	Glutamate receptor ionotropic, NMDA 2B	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	TAS	21157398	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05918	p38 MAPK pathway	P06026	MEKK4	RAT|RGD=1311192|UniProtKB=A0A0G2K3R1	Protein Map3k4	ISS	97236778	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	MOUSE|MGI=MGI=95809|UniProtKB=P23819	Glutamate receptor 2	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IDA	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00001	Adrenaline and noradrenaline biosynthesis	P00070	VAT2	PANTR|Ensembl=ENSPTRG00000002979|UniProtKB=H2Q2M8	Uncharacterized protein	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00006	Apoptosis signaling pathway	P00260	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01078	VAChT	PANTR|Ensembl=ENSPTRG00000002490|UniProtKB=H2Q1W2	Uncharacterized protein	ISS	21863848	PubMed	PTHR23506:SF13	VESICULAR ACETYLCHOLINE TRANSPORTER
P00020	FAS signaling pathway	P00615	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CHICK|Ensembl=ENSGALG00000011809|UniProtKB=F1NMB0	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	RCA	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00046	Oxidative stress response	P01131	MKP5	RAT|RGD=735026|UniProtKB=Q63340	Dual specificity protein phosphatase 7 (Fragment)	ISS			PTHR10159:SF305	DUAL SPECIFICITY PROTEIN PHOSPHATASE 7
P00054	Toll receptor signaling pathway	P01373	CD14	RAT|RGD=620588|UniProtKB=Q63691	Monocyte differentiation antigen CD14	ISS			PTHR10630:SF3	MONOCYTE DIFFERENTIATION ANTIGEN CD14
P00024	Glycolysis	P00678	Enolase	DANRE|ZFIN=ZDB-GENE-030131-6048|UniProtKB=Q6PC12	Enolase 1, (Alpha)	ISS	99439677	PubMed	PTHR11902:SF12	ALPHA-ENOLASE
P00057	Wnt signaling pathway	P01435	SWI/SNF	MONDO|Ensembl=ENSMODG00000009857|UniProtKB=F7A4E9	Uncharacterized protein (Fragment)	ISS	11532957	PubMed	PTHR13844:SF2	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D MEMBER 2
P02738	De novo purine biosynthesis	P02901	Adenosuccinate lyase	METJA|EnsemblGenome=MJ_0929|UniProtKB=Q58339	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P00019	Endothelin signaling pathway	P00590	IP3 R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00048	PI3 kinase pathway	P01190	PDK1 ACT	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	IDA	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00021	FGF signaling pathway	P00632	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	HUMAN|HGNC=4588|UniProtKB=O15399	Glutamate receptor ionotropic, NMDA 2D	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04392	P53 pathway feedback loops 1	P04540	Cop-1	HUMAN|HGNC=17440|UniProtKB=Q8NHY2	E3 ubiquitin-protein ligase RFWD2	IDA	15103385	PubMed	PTHR44080:SF1	E3 UBIQUITIN-PROTEIN LIGASE RFWD2
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	BOVIN|Ensembl=ENSBTAG00000018445|UniProtKB=E1BK87	Uncharacterized protein	ISS	11319238	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00034	Integrin signalling pathway	P00947	Laminin	MOUSE|MGI=MGI=99892|UniProtKB=P19137	Laminin subunit alpha-1	IPI	2538453	PubMed	PTHR10574:SF299	LAMININ SUBUNIT ALPHA-1
P04398	p53 pathway feedback loops 2	P04651	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00011	Blood coagulation	P00433	uPAR	HUMAN|HGNC=9052|UniProtKB=P00749	Urokinase-type plasminogen activator	ISS			PTHR24264:SF38	UROKINASE-TYPE PLASMINOGEN ACTIVATOR
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00034	Integrin signalling pathway	P00924	Raf	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	PANTR|Ensembl=ENSPTRG00000022200|UniProtKB=H2QZ11	Interleukin 13 receptor, alpha 2	ISS	12816724	PubMed	PTHR23036:SF101	INTERLEUKIN-13 RECEPTOR SUBUNIT ALPHA-2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	TAKRU|Ensembl=ENSTRUG00000016101|UniProtKB=H2UW32	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01465	Ggamma	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P05734	Synaptic vesicle trafficking	P05774	NSF	MONDO|Ensembl=ENSMODG00000011031|UniProtKB=F7F4B9	Uncharacterized protein	ISS	11348590	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=620420|UniProtKB=Q91XU7	Cadherin-related family member 1	IDA	8120095	PubMed	PTHR44506:SF1	CADHERIN-RELATED FAMILY MEMBER 1
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IGI	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	MACMU|Ensembl=ENSMMUG00000018634|UniProtKB=F7ACZ9	S-adenosylmethionine synthase	ISS			PTHR11964:SF11	S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-1
P00056	VEGF signaling pathway	P01425	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	2837282	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00037	Ionotropic glutamate receptor pathway	P01026	KA	PANTR|Ensembl=ENSPTRG00000013825|UniProtKB=H2RAK4	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05731	GABA-B receptor II signaling	P05754	Ggamma	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	IDA	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00047	PDGF signaling pathway	P01162	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00049	Parkinson disease	P01211	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05915	Opioid proenkephalin pathway	P05994	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00029	Huntington disease	P00786	ARF	HUMAN|HGNC=659|UniProtKB=P62330	ADP-ribosylation factor 6	IPI	12932731	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	MACMU|Ensembl=ENSMMUG00000000289|UniProtKB=F7A9T0	Uncharacterized protein	ISS	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CANLF|Ensembl=ENSCAFG00000012181|UniProtKB=F2Z4N7	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00006	Apoptosis signaling pathway	P00269	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MOUSE|MGI=MGI=95815|UniProtKB=P39087	Glutamate receptor ionotropic, kainate 2	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00223	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01242	Casein kinase I	SCHPO|PomBase=SPBP35G2.05c|UniProtKB=P40234	Casein kinase I homolog 2	IDA	11437445	PubMed	PTHR11909:SF155	GILGAMESH, ISOFORM L
P00009	Axon guidance mediated by netrin	P00363	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	11292874	PubMed	PTHR10048:SF14	PI-3 KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-486685|UniProtKB=F6VT32	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05731	GABA-B receptor II signaling	P05754	Ggamma	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	88241036	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06827	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	RCA	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00034	Integrin signalling pathway	P00948	Rho	MOUSE|MGI=MGI=107949|UniProtKB=P62746	Rho-related GTP-binding protein RhoB	ISS	13679859	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000006999|UniProtKB=E1BDQ4	Uncharacterized protein	ISS	8930069	PubMed	PTHR13715:SF15	RYANODINE RECEPTOR 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	MOUSE|MGI=MGI=104755|UniProtKB=P48545	G protein-activated inward rectifier potassium channel 4	IDA	2433589	PubMed	PTHR11767:SF52	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 4
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	YEAST|SGD=S000003244|UniProtKB=P53206	Putative cysteine synthase	ISS			PTHR10314:SF35	CYSTEINE SYNTHASE-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Ensembl=ENSPTRG00000018449|UniProtKB=H2QTG5	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00047	PDGF signaling pathway	P01153	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00011	Blood coagulation	P00421	alpha1-antitrypsin	HUMAN|HGNC=8941|UniProtKB=P01009	Alpha-1-antitrypsin	ISS	2116650	gi	PTHR11461:SF165	ALPHA-1-ANTITRYPSIN-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	HUMAN|HGNC=144|UniProtKB=P63261	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00034	Integrin signalling pathway	P00916	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04376	5HT4 type receptor mediated signaling pathway	P04426	K+ channel	HUMAN|HGNC=6283|UniProtKB=Q9NPC2	Potassium channel subfamily K member 9	ISS	15282272	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00049	Parkinson disease	P01238	14-3-3	PANTR|Ensembl=ENSPTRG00000013529|UniProtKB=H2R8X6	Uncharacterized protein	ISS	91108808	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04658	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00012	Cadherin signaling pathway	P00462	Casein kinase II	PANTR|Ensembl=ENSPTRG00000008175|UniProtKB=H2RA57	Uncharacterized protein	ISS	10806215	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05915	Opioid proenkephalin pathway	P05990	K+ channel	HUMAN|HGNC=6283|UniProtKB=Q9NPC2	Potassium channel subfamily K member 9	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P05913	Enkephalin release	P05974	G-Protein (i)	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00054	Toll receptor signaling pathway	P01364	TPL2	BOVIN|Ensembl=ENSBTAG00000011600|UniProtKB=A5PK86	MAP3K8 protein	ISS	99133929	PubMed	PTHR24361:SF94	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MACMU|Ensembl=ENSMMUG00000010440|UniProtKB=F7CRV6	Uncharacterized protein	ISS	8163524	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00034	Integrin signalling pathway	P00944	Actin	MOUSE|MGI=MGI=87904|UniProtKB=P60710	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00006	Apoptosis signaling pathway	P00324	NIK	HUMAN|HGNC=6853|UniProtKB=Q99558	Mitogen-activated protein kinase kinase kinase 14	RCA			PTHR24361:SF226	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 14
P00006	Apoptosis signaling pathway	P00321	HSP70	PHYPA|Gene=PHYPADRAFT_207434|UniProtKB=A9S0A3	Predicted protein	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00056	VEGF signaling pathway	P01417	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	IC	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	BOVIN|Gene=ACVR2B|UniProtKB=Q95126	Activin receptor type-2B	TAS	11252892	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PANTR|Ensembl=ENSPTRG00000006890|UniProtKB=H2Q943	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00053	T cell activation	P01316	MHC-antigen	HUMAN|HGNC=4947|UniProtKB=P01903	HLA class II histocompatibility antigen, DR alpha chain	ISS	73139	PubMed	PTHR19944:SF63	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	DANRE|ZFIN=ZDB-GENE-030131-8783|UniProtKB=Q52WY2	Ras-like protein Cdc42a	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_127489|UniProtKB=C3XYC6	Putative uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	97102671	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00020	FAS signaling pathway	P00615	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00037	Ionotropic glutamate receptor pathway	P01015	Glu4	DANRE|ZFIN=ZDB-GENE-030131-8013|UniProtKB=F1QBT6	Uncharacterized protein	ISS	12497607	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00034	Integrin signalling pathway	P00948	Rho	HUMAN|HGNC=668|UniProtKB=P62745	Rho-related GTP-binding protein RhoB	ISS	11973360	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00059	p53 pathway	P04622	Sin3	MOUSE|MGI=MGI=107157|UniProtKB=Q60520	Paired amphipathic helix protein Sin3a	ISS	10441327	PubMed	PTHR12346:SF2	PAIRED AMPHIPATHIC HELIX PROTEIN SIN3A
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	PANTR|Ensembl=ENSPTRG00000009085|UniProtKB=H2RDQ2	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g239788|UniProtKB=A7RPI8	Predicted protein	ISS	3885394	PubMed	PTHR23050:SF245	AT16150P-RELATED
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	CANAL|CGD=CAL0000189182|UniProtKB=P12461	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00049	Parkinson disease	P01211	ERK	RAT|RGD=621505|UniProtKB=P0C865	Mitogen-activated protein kinase 7	ISS	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00021	FGF signaling pathway	P00624	14-3-3	TAKRU|Ensembl=ENSTRUG00000004697|UniProtKB=H2SFG7	Uncharacterized protein	ISS	1317796	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00012	Cadherin signaling pathway	P00469	Fer	MOUSE|MGI=MGI=105917|UniProtKB=P70451	Tyrosine-protein kinase Fer	ISS	9742093	PubMed	PTHR24418:SF227	TYROSINE-PROTEIN KINASE FER
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	TAS	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04674	Mdm2	DANRE|ZFIN=ZDB-GENE-990415-153|UniProtKB=O42354	E3 ubiquitin-protein ligase Mdm2	IGI	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MACMU|Ensembl=ENSMMUG00000014762|UniProtKB=F7G0R4	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF344	MYOSIN-7
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	BOVIN|Gene=PPP1CB|UniProtKB=Q3SWW9	Serine/threonine-protein phosphatase PP1-beta catalytic subunit	ISS	10433257	PubMed	PTHR11668:SF282	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-BETA CATALYTIC SUBUNIT
P04397	p53 pathway by glucose deprivation	P04641	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00029	Huntington disease	P00788	Calpain	HUMAN|HGNC=1476|UniProtKB=P07384	Calpain-1 catalytic subunit	IDA	11675509	PubMed	PTHR10183:SF284	CALPAIN-1 CATALYTIC SUBUNIT
P00053	T cell activation	P01332	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00036	Interleukin signaling pathway	P00965	ERK	MACMU|Ensembl=ENSMMUG00000001187|UniProtKB=F6R8N9	Mitogen-activated protein kinase	ISS	11875070	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00021	FGF signaling pathway	P00640	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	MACMU|Ensembl=ENSMMUG00000009287|UniProtKB=F7H3T9	Glutamate receptor 1 isoform 1	ISS	10331083	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	HUMAN|HGNC=7174|UniProtKB=P09237	Matrilysin	TAS	12356903	PubMed	PTHR10201:SF143	MATRILYSIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00644	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00964	p90RSK	CANLF|Ensembl=ENSCAFG00000013171|UniProtKB=E2RP04	Uncharacterized protein	ISS	2779569	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00029	Huntington disease	P00786	ARF	DROME|FlyBase=FBgn0010348|UniProtKB=P61209	ADP-ribosylation factor 1	IPI	12932731	PubMed	PTHR11711:SF304	ADP-RIBOSYLATION FACTOR 1
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CAEEL|WormBase=WBGene00000063|UniProtKB=P0DM41	Actin-1	IDA	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P05731	GABA-B receptor II signaling	P05754	Ggamma	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DANRE|ZFIN=ZDB-GENE-000329-3|UniProtKB=Q7ZVF9	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00059	p53 pathway	P01486	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01226	CDCrel-1	RAT|RGD=1307216|UniProtKB=Q5EB96	Septin-1	ISS			PTHR18884:SF6	SEPTIN-1
P05916	Opioid prodynorphin pathway	P06002	G-protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05731	GABA-B receptor II signaling	P05760	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P02772	Pyruvate metabolism	P03132	Pyruvate Kinase	PYRAE|EnsemblGenome=PAE0819|UniProtKB=Q8ZYE0	Pyruvate kinase	ISS	11792869	PubMed	PTHR11817:SF3	AT14039P-RELATED
P00005	Angiogenesis	P00219	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00057	Wnt signaling pathway	P01444	Wnt	MACMU|Ensembl=ENSMMUG00000002439|UniProtKB=F6PJN8	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	BACSU|EnsemblGenome=BSU13170|UniProtKB=O34598	Guanine deaminase	ISS			PTHR44192:SF2	SUBFAMILY NOT NAMED
P05916	Opioid prodynorphin pathway	P06002	G-protein	CANLF|Ensembl=ENSCAFG00000015662|UniProtKB=E2RHY4	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00021	FGF signaling pathway	P00644	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01078	VAChT	HUMAN|HGNC=10936|UniProtKB=Q16572	Vesicular acetylcholine transporter	IC			PTHR23506:SF13	VESICULAR ACETYLCHOLINE TRANSPORTER
P00057	Wnt signaling pathway	P01451	Galpha	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05917	Opioid proopiomelanocortin pathway	P06011	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	DANRE|ZFIN=ZDB-GENE-030131-8783|UniProtKB=Q52WY2	Ras-like protein Cdc42a	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000002016|UniProtKB=F1P3G1	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS			PTHR13808:SF5	CREB-BINDING PROTEIN
P00035	Interferon-gamma signaling pathway	P00958	PIAS	CHICK|Ensembl=ENSGALG00000007970|UniProtKB=F1NSG6	Uncharacterized protein	ISS	8682149	PubMed	PTHR10782:SF11	E3 SUMO-PROTEIN LIGASE PIAS1
P00045	Notch signaling pathway	P01103	Next	HUMAN|HGNC=7881|UniProtKB=P46531	Neurogenic locus notch homolog protein 1	IGI	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000013529|UniProtKB=F6Z6U0	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF323	CADHERIN-19
P00045	Notch signaling pathway	P01103	Next	MONDO|Ensembl=ENSMODG00000004910|UniProtKB=F7C1Q4	Delta-like protein	ISS	10551863	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00054	Toll receptor signaling pathway	P01341	Elk1	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	3183861	gi	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00011	Blood coagulation	P00458	GP IIIa	HUMAN|Ensembl=ENSG00000259753|UniProtKB=H3BM21	Integrin beta (Fragment)	ISS	20069419	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00006	Apoptosis signaling pathway	P00260	AKT	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01303	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	7689150	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00010	B cell activation	P00371	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01301	TCR alpha	MACMU|Ensembl=ENSMMUG00000021105|UniProtKB=F7GW97	Uncharacterized protein	IDA			PTHR19433:SF76	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00644	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	12810719	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	MOUSE|MGI=MGI=95739|UniProtKB=P15105	Glutamine synthetase	ISS			PTHR20852:SF45	GLUTAMINE SYNTHETASE
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	88241036	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00015	Circadian clock system	G01501	cry	PANTR|Ensembl=ENSPTRG00000003537|UniProtKB=H2Q3H0	Uncharacterized protein	ISS	11533252	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=99551|UniProtKB=Q9WTR5	Cadherin-13	IDA	8120095	PubMed	PTHR24027:SF80	CADHERIN-13
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00036	Interleukin signaling pathway	P00977	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00018	EGF receptor signaling pathway	P00562	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	BOVIN|Gene=DRD2|UniProtKB=P20288	D(2) dopamine receptor	ISS	1319557	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00010	B cell activation	P00391	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01236	Casein kinase II	PHYPA|Gene=PHYPADRAFT_218940|UniProtKB=A9T4Y7	Predicted protein	ISS	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01408	Akt/PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IDA	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00010	B cell activation	P00401	jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00047	PDGF signaling pathway	P01142	p90RSK	PANTR|Ensembl=ENSPTRG00000003957|UniProtKB=H2Q486	Ribosomal protein S6 kinase	ISS	15116068	PubMed	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00029	Huntington disease	P00786	ARF	ANOGA|EnsemblGenome=AGAP006890|UniProtKB=Q7QII7	AGAP006890-PA	IPI	12932731	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P02728	Arginine biosynthesis	P02840	Argininosuccinate synthase	HUMAN|HGNC=758|UniProtKB=P00966	Argininosuccinate synthase	ISS			PTHR11587:SF2	ARGININOSUCCINATE SYNTHASE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	TAKRU|Ensembl=ENSTRUG00000009259|UniProtKB=H2TF39	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00049	Parkinson disease	P01211	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01306	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00060	Ubiquitin proteasome pathway	P01491	E2	CANLF|Ensembl=ENSCAFG00000024756|UniProtKB=F1PDI6	Uncharacterized protein	ISS			PTHR24068:SF48	UBIQUITIN-CONJUGATING ENZYME E2 D3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00990	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04542	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00020	FAS signaling pathway	P00604	Pro-Caspase8	PANTR|Ensembl=ENSPTRG00000012801|UniProtKB=H2QJ86	Caspase 8, apoptosis-related cysteine peptidase	ISS	8681376	PubMed	PTHR10454:SF162	CASPASE-8
P05916	Opioid prodynorphin pathway	P06002	G-protein	SCLS1|EnsemblGenome=SS1G_03482|UniProtKB=A7EDU2	Guanine nucleotide-binding protein beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00053	T cell activation	P01295	vav	RAT|RGD=1565941|UniProtKB=F1LWB1	Protein Vav3	ISS	14623913	PubMed	PTHR22826:SF97	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04665	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00018	EGF receptor signaling pathway	P00557	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	MACMU|Ensembl=ENSMMUG00000021393|UniProtKB=F7FD86	Calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 1	ISS	12888804	PubMed	PTHR43940:SF7	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT GAMMA
P00004	Alzheimer disease-presenilin pathway	P00114	actin	TRIVA|Gene=TVAG_512800|UniProtKB=A2HNG1	Actin (Fragment)	IDA			PTHR11937:SF155	ACTIN-5C-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P06959	CCKR signaling map	P07020	p110	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	RCA	16297869	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02740	De novo pyrimidine ribonucleotides biosythesis	P02926	Aspartate carbamoyltransferase	ARATH|TAIR=AT3G20330|UniProtKB=P49077	Aspartate carbamoyltransferase, chloroplastic	ISS			PTHR11405:SF16	ASPARTATE CARBAMOYLTRANSFERASE, CHLOROPLASTIC
P05912	Dopamine receptor mediated signaling pathway	P05961	DOPA decarb.	CAEEL|WormBase=WBGene00000239|UniProtKB=O45137	Biogenic Amine Synthesis related	ISS	7567987	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P04393	Ras Pathway	P04556	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01320	PLC-gamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04398	p53 pathway feedback loops 2	P04658	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00007	Axon guidance mediated by semaphorins	P00340	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MOUSE|MGI=MGI=1340026|UniProtKB=P33435	Collagenase 3	TAS	91093077	PubMed	PTHR10201:SF165	COLLAGENASE 3
P00057	Wnt signaling pathway	P01451	Galpha	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04396	Vitamin D metabolism and pathway	P04605	P450 reductase	MACMU|Ensembl=ENSMMUG00000020086|UniProtKB=F7GP55	NADPH--cytochrome P450 reductase	ISS	2513880	PubMed	PTHR19384:SF17	NADPH--CYTOCHROME P450 REDUCTASE
P00010	B cell activation	P00391	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	TAS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00019	Endothelin signaling pathway	P00566	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00780	Microtubule	DAPPU|EnsemblGenome=DAPPUDRAFT_300845|UniProtKB=E9HEX5	Putative uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF250	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00019	Endothelin signaling pathway	P00590	IP3 R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00012	Cadherin signaling pathway	P00475	Frizzled	DANRE|ZFIN=ZDB-GENE-990415-220|UniProtKB=Q9W6E3	Frizzled homolog 10	IDA	11212302	PubMed	PTHR11309:SF86	FRIZZLED-10
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	TAKRU|Ensembl=ENSTRUG00000008018|UniProtKB=H2T5N4	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00304	XIAP	MOUSE|MGI=MGI=107572|UniProtKB=Q60989	E3 ubiquitin-protein ligase XIAP	ISS			PTHR10044:SF115	BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 8-RELATED
P00034	Integrin signalling pathway	P00916	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00018	EGF receptor signaling pathway	P00546	GAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05917	Opioid proopiomelanocortin pathway	P06007	alpha-MSH	MACMU|Ensembl=ENSMMUG00000016463|UniProtKB=F7GBI0	Uncharacterized protein	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P04398	p53 pathway feedback loops 2	P04665	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000000843|UniProtKB=H2QZN8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	MONDO|Ensembl=ENSMODG00000017905|UniProtKB=F7FG65	Tyrosine-protein kinase	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00047	PDGF signaling pathway	P01174	Rho	ORNAN|Ensembl=ENSOANG00000005383|UniProtKB=F6VH29	Uncharacterized protein	ISS			PTHR14166:SF6	SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 2-RELATED
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00057	Wnt signaling pathway	P01438	PP2A	MOUSE|MGI=MGI=1349475|UniProtKB=Q60996	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	IDA	10092233	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P05918	p38 MAPK pathway	P06042	4E-BP1	BOVIN|Ensembl=ENSBTAG00000027654|UniProtKB=Q0P5A7	Eukaryotic translation initiation factor 4E-binding protein 1	ISS	12820960	PubMed	PTHR12669:SF14	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=1310389|UniProtKB=D3ZTF6	Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Predicted), isoform CRA_a	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00005	Angiogenesis	P00203	Erk	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00053	T cell activation	P01332	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01316	MHC-antigen	HUMAN|HGNC=1697|UniProtKB=P04233	HLA class II histocompatibility antigen gamma chain	IPI	73139	PubMed	PTHR14093:SF17	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN GAMMA CHAIN
P00015	Circadian clock system	G01503	per	MOUSE|MGI=MGI=1195265|UniProtKB=O54943	Period circadian protein homolog 2	ISS			PTHR11269:SF9	PERIOD CIRCADIAN PROTEIN HOMOLOG 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MACMU|Ensembl=ENSMMUG00000012054|UniProtKB=F6TII3	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P06209	ALP23B signaling pathway	P06219	LACK	DROME|FlyBase=FBgn0029006|UniProtKB=Q9V853	E3 ubiquitin-protein ligase Smurf1	IEA	http://flybase.org/reports/FBgn0029006.html	Website	PTHR11254:SF395	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P05913	Enkephalin release	P05978	AC	RAT|RGD=619965|UniProtKB=P26769	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00165	E-cadherin N-terminal fragment	HUMAN|HGNC=1748|UniProtKB=P12830	Cadherin-1	TAS	11953314	PubMed	PTHR24027:SF319	CADHERIN-1
P00021	FGF signaling pathway	P00629	PP2A	RAT|RGD=620919|UniProtKB=P36876	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform	IDA	137056	PubMed	PTHR11871:SF2	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04453	ACTH	BOVIN|Ensembl=ENSBTAG00000007897|UniProtKB=P01190	Pro-opiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00035	Interferon-gamma signaling pathway	P00952	Jak2	MONDO|Ensembl=ENSMODG00000015373|UniProtKB=F6WH53	Tyrosine-protein kinase	ISS	22482294	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00019	Endothelin signaling pathway	P00568	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IGI	3045562	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	MOUSE|MGI=MGI=94925|UniProtKB=P30728	D(3) dopamine receptor	RCA	11248120	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000022936|UniProtKB=F6U709	Uncharacterized protein	ISS	2137198	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00238	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00034	Integrin signalling pathway	P00940	Src	MACMU|Ensembl=ENSMMUG00000020131|UniProtKB=F7FWN4	Tyrosine-protein kinase	ISS	8054685	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05730	Endogenous cannabinoid signaling	P05751	Galpha	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00030	Hypoxia response via HIF activation	P00819	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06780	ActRII/IIB	MOUSE|MGI=MGI=87912|UniProtKB=P27040	Activin receptor type-2B	RCA	9395284	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	DANRE|ZFIN=ZDB-GENE-990415-9|UniProtKB=O73736	Receptor protein serine/threonine kinase	TAS	9395284	PubMed	PTHR23255:SF65	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00060	Ubiquitin proteasome pathway	P01491	E2	PANTR|Ensembl=ENSPTRG00000014693|UniProtKB=H2QM68	Ubiquitin-conjugating enzyme E2E 1	ISS			PTHR24068:SF70	UBIQUITIN-CONJUGATING ENZYME E2 E1
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	MONDO|Ensembl=ENSMODG00000001626|UniProtKB=F6TN69	Uncharacterized protein (Fragment)	ISS	15858232	PubMed	PTHR13715:SF16	RYANODINE RECEPTOR 3
P00053	T cell activation	P01320	PLC-gamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00019	Endothelin signaling pathway	P00578	eNOS	MACMU|Ensembl=ENSMMUG00000020437|UniProtKB=F6WEB2	Nitric oxide synthase	ISS	93055452	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00018	EGF receptor signaling pathway	P00545	JNK1-3	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02742	Tetrahydrofolate biosynthesis	P02951	GTP cyclohydrolase	CANLF|Ensembl=ENSCAFG00000014965|UniProtKB=E2RI70	Uncharacterized protein	ISS			PTHR11109:SF0	GTP CYCLOHYDROLASE 1
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=106612|UniProtKB=Q9WTI7	Unconventional myosin-Ic	IC			PTHR13140:SF255	UNCONVENTIONAL MYOSIN-IC
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00981	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01327	Gads	PANTR|Ensembl=ENSPTRG00000014404|UniProtKB=H2QLR1	Uncharacterized protein	ISS	10021361	PubMed	PTHR24418:SF299	GRB2-RELATED ADAPTER PROTEIN 2
P00057	Wnt signaling pathway	P01461	FrzB	MOUSE|MGI=MGI=892032|UniProtKB=P97401	Secreted frizzled-related protein 3	ISS	9118218	PubMed	PTHR11309:SF97	SECRETED FRIZZLED-RELATED PROTEIN 3
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04398	p53 pathway feedback loops 2	G04709	MDM-2	MOUSE|MGI=MGI=107934|UniProtKB=O35618	Protein Mdm4	ISS			PTHR13844:SF20	PROTEIN MDM4
P00029	Huntington disease	P00772	FIP-2	MONDO|Ensembl=ENSMODG00000013541|UniProtKB=F7CLW1	Uncharacterized protein	ISS			PTHR12757:SF3	TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00632	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IGI	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00797	p53	RAT|RGD=620863|UniProtKB=Q9JJP6	Tumor protein 63	TAS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00007	Axon guidance mediated by semaphorins	P00338	Neuropilin 1	CANLF|Ensembl=ENSCAFG00000003776|UniProtKB=F6UNY1	Uncharacterized protein	ISS	9288754	PubMed	PTHR44185:SF1	NEUROPILIN-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000002775|UniProtKB=H2RB55	Phosphoinositide phospholipase C	ISS			PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	PANTR|Ensembl=ENSPTRG00000009415|UniProtKB=H2QDG2	Nucleoside diphosphate kinase	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	MACMU|Ensembl=ENSMMUG00000006253|UniProtKB=F7H582	Uncharacterized protein	ISS	92409599	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00717	Phosphorylase b	MONDO|Ensembl=ENSMODG00000006424|UniProtKB=F7EZJ9	Alpha-1,4 glucan phosphorylase (Fragment)	ISS	4318782	PubMed	PTHR11468:SF1	GLYCOGEN PHOSPHORYLASE, BRAIN FORM
P04393	Ras Pathway	P04567	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	IDA	1171954	gi	PTHR10048:SF14	PI-3 KINASE
P00056	VEGF signaling pathway	P01402	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	RCA			PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00021	FGF signaling pathway	P00642	MEK1-2	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IGI	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00056	VEGF signaling pathway	P01423	p38MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00252	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	8262390	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00047	PDGF signaling pathway	P01159	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00034	Integrin signalling pathway	P00918	Caveolin	MONDO|Ensembl=ENSMODG00000015826|UniProtKB=F7FDW7	Caveolin	ISS	9741627	PubMed	PTHR10844:SF18	CAVEOLIN-1
P00021	FGF signaling pathway	P00632	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IGI	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06794	MAP2K1/2	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	RCA	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00059	p53 pathway	P04609	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04393	Ras Pathway	P04558	p38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	IDA	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00048	PI3 kinase pathway	P01192	p110	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01174	Rho	CAEBR|Gene=CBG02886|UniProtKB=A8WTA3	Protein CBR-RGA-1	ISS			PTHR23176:SF0	RHO GTPASE-ACTIVATING PROTEIN 68F
P06213	DPP signaling pathway	P06283	TLD	DROME|FlyBase=FBgn0003719|UniProtKB=P25723	Dorsal-ventral patterning protein tolloid	IDA	9759503	PubMed	PTHR43978:SF2	DORSAL-VENTRAL PATTERNING PROTEIN TOLLOID-RELATED
P00056	VEGF signaling pathway	P01425	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02920	dCTP deaminase	ECOLI|EcoGene=EG11418|UniProtKB=P28248	Deoxycytidine triphosphate deaminase	RCA			PTHR42680:SF3	DCTP DEAMINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	15572354	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00005	Angiogenesis	P00216	Caspase 9	PANTR|Ensembl=ENSPTRG00000000200|UniProtKB=H2PY35	Caspase	ISS	8663294	PubMed	PTHR10454:SF157	CASPASE-9
P06664	Gonadotropin-releasing hormone receptor pathway	P06852	nPKCs	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	RCA	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00021	FGF signaling pathway	P00639	Shc	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	ISS	95096035	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01084	CHT1	PANTR|Ensembl=ENSPTRG00000012325|UniProtKB=H2QII0	Uncharacterized protein	RCA			PTHR11819:SF129	HIGH AFFINITY CHOLINE TRANSPORTER 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	RAT|RGD=1304556|UniProtKB=P63259	Actin, cytoplasmic 2	ISS	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IDA	12810719	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	DANRE|ZFIN=ZDB-GENE-991119-4|UniProtKB=Q9W6T7	Presenilin-1	IDA	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00046	Oxidative stress response	P01129	JNK1/2	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	IC	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00021	FGF signaling pathway	P00645	Rac	DICDI|dictyBase=DDB_G0282365|UniProtKB=P34146	Rho-related protein rac1C	ISS	12932731	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	IC	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P06664	Gonadotropin-releasing hormone receptor pathway	P06852	nPKCs	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00019	Endothelin signaling pathway	P00586	Gq	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00967	c-fos	CANLF|Ensembl=ENSCAFG00000017040|UniProtKB=E2QYK5	Uncharacterized protein	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00005	Angiogenesis	P00243	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	10747026	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00005	Angiogenesis	P00182	p38MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01337	B7	PANTR|Ensembl=ENSPTRG00000015256|UniProtKB=H2QN56	Uncharacterized protein	ISS	1650475	PubMed	PTHR25466:SF4	T-LYMPHOCYTE ACTIVATION ANTIGEN CD80
P00019	Endothelin signaling pathway	P00570	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00976	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Gene=PLCD4|UniProtKB=P21671	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	10934033	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00034	Integrin signalling pathway	P00907	ERK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS			PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00034	Integrin signalling pathway	P00944	Actin	CAEEL|WormBase=WBGene00000067|UniProtKB=O45815	ACTin	ISS	11889126	PubMed	PTHR11937:SF352	ACTIN
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	IC	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	SCHPO|PomBase=SPBC1778.08c|UniProtKB=Q9Y7J4	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00047	PDGF signaling pathway	P01160	IP3 receptor	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PRIPA|Gene=PPA19914|UniProtKB=H3FCG4	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF359	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	RCA			PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	SCHPO|PomBase=SPAC110.03|UniProtKB=Q01112	Cell division control protein 42 homolog	ISS	4757952	gi	PTHR24072:SF192	CDC42 HOMOLOG
P06959	CCKR signaling map	P07089	CK1delta/epsilon	HUMAN|HGNC=2453|UniProtKB=P49674	Casein kinase I isoform epsilon	RCA	17962809	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00006	Apoptosis signaling pathway	P00260	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00015	Circadian clock system	G01501	cry	ORNAN|Ensembl=ENSOANG00000005350|UniProtKB=F6X852	Uncharacterized protein	ISS	10217146	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00012	Cadherin signaling pathway	P00462	Casein kinase II	MOUSE|MGI=MGI=88543|UniProtKB=Q60737	Casein kinase II subunit alpha	ISS	10806215	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P02778	Sulfate assimilation	P03164	Adenylylsulfate kinase	PSEAE|EnsemblGenome=PA1393|UniProtKB=P57702	Adenylyl-sulfate kinase	ISS			PTHR11055:SF27	ADENYLYL-SULFATE KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	XENTR|Xenbase=XB-GENE-482228|UniProtKB=F6RYL1	Uncharacterized protein	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P05915	Opioid proenkephalin pathway	P05995	proenkephalin	BOVIN|Ensembl=ENSBTAG00000004924|UniProtKB=P01211	Proenkephalin-A	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02728	Arginine biosynthesis	P02840	Argininosuccinate synthase	AQUAE|EnsemblGenome=aq_1140|UniProtKB=O67213	Argininosuccinate synthase	ISS			PTHR11587:SF2	ARGININOSUCCINATE SYNTHASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00057	Wnt signaling pathway	P01444	Wnt	BOVIN|Ensembl=ENSBTAG00000002664|UniProtKB=F1N7G3	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF84	PROTEIN WNT-9B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00828	Galphai	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	RCA			PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P06664	Gonadotropin-releasing hormone receptor pathway	P06768	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	RCA	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	CANLF|Gene=GRIN1|UniProtKB=Q5R1P0	Glutamate receptor ionotropic, NMDA 1	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IC	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	8787761	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P04633	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	SCHPO|PomBase=SPAPYUG7.05|UniProtKB=Q9P7Y7	Pyrroline-5-carboxylate reductase	ISS			PTHR11645:SF0	PYRROLINE-5-CARBOXYLATE REDUCTASE
P00018	EGF receptor signaling pathway	P00550	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00008	Axon guidance mediated by Slit/Robo	P00344	Netrin	BOVIN|Ensembl=ENSBTAG00000012137|UniProtKB=F1N0C7	Uncharacterized protein	ISS	11356879	PubMed	PTHR10574:SF365	NETRIN-1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05730	Endogenous cannabinoid signaling	P05746	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00021	FGF signaling pathway	P00627	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	12657601	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04393	Ras Pathway	P04559	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-2280|UniProtKB=Q6P025	Gnb3 protein	ISS			PTHR19850:SF35	GNB3 PROTEIN
P00034	Integrin signalling pathway	P00922	Collagen	HUMAN|HGNC=2190|UniProtKB=Q5TAT6	Collagen alpha-1(XIII) chain	IDA	10778855	PubMed	PTHR44988:SF1	COLLAGEN ALPHA-1 XIII  CHAIN
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00050	Plasminogen activating cascade	P01253	Fibrin	MACMU|Ensembl=ENSMMUG00000021304|UniProtKB=F6UYY8	Uncharacterized protein	ISS	80015086	PubMed	PTHR19143:SF338	FIBRINOGEN GAMMA CHAIN
P00046	Oxidative stress response	P01135	p38	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00025	Hedgehog signaling pathway	P00682	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00059	p53 pathway	P04633	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01150	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00054	Toll receptor signaling pathway	P01371	TRAF6	PANTR|Ensembl=ENSPTRG00000003510|UniProtKB=H2Q3F3	TNF receptor-associated factor 6	ISS			PTHR10131:SF111	TNF RECEPTOR-ASSOCIATED FACTOR 6
P00021	FGF signaling pathway	P00627	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	LEIMA|EnsemblGenome=LmjF.35.3960|UniProtKB=E9AFM1	Protein kinase A catalytic subunit isoform 2	ISS	10218114	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01444	Wnt	CHICK|Ensembl=ENSGALG00000005123|UniProtKB=Q9DEB8	Protein Wnt	IDA	12549854	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IDA	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00047	PDGF signaling pathway	P01161	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	RAT|RGD=2156|UniProtKB=P29066	Beta-arrestin-1	IDA	9388255	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00023	General transcription regulation	P00658	TBP-associated factors	CANLF|Ensembl=ENSCAFG00000000875|UniProtKB=F6UTN8	Uncharacterized protein	ISS			PTHR15137:SF9	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2
P00011	Blood coagulation	P00439	Prekallikrein	RAT|RGD=67382|UniProtKB=P14272	Plasma kallikrein	ISS	6680584	gi	PTHR44459:SF2	PLASMA KALLIKREIN
P04393	Ras Pathway	P04572	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P06587	Nicotine pharmacodynamics pathway	P06604	SLC18A2	MOUSE|MGI=MGI=106677|UniProtKB=Q8BRU6	Synaptic vesicular amine transporter	TAS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P06959	CCKR signaling map	G07263	IEX1	HUMAN|HGNC=5392|UniProtKB=P46695	Radiation-inducible immediate-early gene IEX-1	RCA	17704804	PubMed	PTHR16915:SF0	RADIATION-INDUCIBLE IMMEDIATE-EARLY GENE IEX-1
P00009	Axon guidance mediated by netrin	P00363	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02754	Methylcitrate cycle	P03028	Aconitase	MOUSE|MGI=MGI=87879|UniProtKB=P28271	Cytoplasmic aconitate hydratase	ISS			PTHR11670:SF32	CYTOPLASMIC ACONITATE HYDRATASE
P00004	Alzheimer disease-presenilin pathway	P00165	E-cadherin N-terminal fragment	HUMAN|HGNC=1762|UniProtKB=P22223	Cadherin-3	TAS	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P04393	Ras Pathway	P04552	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P02747	Histidine biosynthesis	P02993	Phosphoribosylformimino-5-amino-1-phosphoribosyl-4 imadazol carboxamide isomerase	STRCO|EnsemblGenome=CAB51442|UniProtKB=P16250	Phosphoribosyl isomerase A	ISS			PTHR43090:SF2	1- 5-PHOSPHORIBOSYL -5-  5-PHOSPHORIBOSYLAMINO METHYLIDENEAMINO  IMIDAZOLE-4-CARBOXAMIDE ISOMERASE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	RAT|RGD=1308152|UniProtKB=Q5FVM5	Cyclic AMP-responsive element-binding protein 3-like protein 3	ISS	1354612	PubMed	PTHR22952:SF98	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 3
P00029	Huntington disease	P00807	Actin	CHICK|Ensembl=ENSGALG00000009621|UniProtKB=P60706	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	IPI	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00470	F-actin	ORNAN|Ensembl=ENSOANG00000007405|UniProtKB=F7CIV4	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05913	Enkephalin release	P05972	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05915	Opioid proenkephalin pathway	P05991	Enkephalin	HUMAN|HGNC=8831|UniProtKB=P01210	Proenkephalin-A	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00049	Parkinson disease	P01208	Hsp70	ARATH|TAIR=AT1G16030|UniProtKB=Q9S9N1	Heat shock 70 kDa protein 5	IDA	12150907	PubMed	PTHR19375:SF321	HEAT SHOCK 70 KDA PROTEIN 5
P00059	p53 pathway	P01486	Akt	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	TAS	22084520	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P02759	Pyridoxal-5-phosphate biosynthesis	P03061	Pyridoxine-5-phosphate oxidase	HUMAN|HGNC=30260|UniProtKB=Q9NVS9	Pyridoxine-5'-phosphate oxidase	ISS	14697241	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01438	PP2A	MONDO|Ensembl=ENSMODG00000014177|UniProtKB=F6U7A6	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00021	FGF signaling pathway	P00633	Ras	DICPU|Gene=DICPUDRAFT_92731|UniProtKB=F0ZWE6	Putative uncharacterized protein rasG	ISS	89128893	PubMed	PTHR24070:SF282	RAS GTPASE-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	NEUCR|EnsemblGenome=EFNCRG00000002499|UniProtKB=Q7SDQ8	26S protease regulatory subunit 7	ISS			PTHR23073:SF13	26S PROTEASE REGULATORY SUBUNIT 7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	MACMU|Ensembl=ENSMMUG00000017654|UniProtKB=F6UI32	Beta-arrestin-2 isoform 1	ISS	11742073	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00053	T cell activation	P01311	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IDA	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01219	SAPK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	NAS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MONDO|Ensembl=ENSMODG00000016595|UniProtKB=F6ZDB2	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00053	T cell activation	P01307	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00047	PDGF signaling pathway	P01145	c-fos	TAKRU|Ensembl=ENSTRUG00000018314|UniProtKB=H2VCA7	Uncharacterized protein (Fragment)	ISS			PTHR23351:SF22	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00641	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	RAT|RGD=2744|UniProtKB=P31422	Metabotropic glutamate receptor 3	ISS	20012997	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00012	Cadherin signaling pathway	P00463	betacatenin	ORNAN|Ensembl=ENSOANG00000006811|UniProtKB=F6WBD5	Uncharacterized protein	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00019	Endothelin signaling pathway	P00581	Guanylate cyclase	RAT|RGD=68436|UniProtKB=P19686	Guanylate cyclase soluble subunit alpha-3	RCA			PTHR11920:SF226	GUANYLATE CYCLASE SOLUBLE SUBUNIT ALPHA-3
P00057	Wnt signaling pathway	P01444	Wnt	MACMU|Ensembl=ENSMMUG00000015705|UniProtKB=F6SM00	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00021	FGF signaling pathway	P00645	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00030	Hypoxia response via HIF activation	P00814	P300	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	IDA	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00030	Hypoxia response via HIF activation	P00824	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00005	Angiogenesis	P00206	Wnt	DANRE|ZFIN=ZDB-GENE-051129-1|UniProtKB=Q4JLT0	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MOUSE|MGI=MGI=95817|UniProtKB=Q8BMF5	Glutamate receptor ionotropic, kainate 4	ISS	1648176	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	MOUSE|MGI=MGI=894644|UniProtKB=Q8CC27	Voltage-dependent L-type calcium channel subunit beta-2	IC	20088160	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	DROME|FlyBase=FBgn0020621|UniProtKB=A1Z7T0	Serine/threonine-protein kinase N	TAS	10644715	PubMed	PTHR24356:SF210	SERINE/THREONINE-PROTEIN KINASE N
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00012	Cadherin signaling pathway	P00466	EGFR	MOUSE|MGI=MGI=95410|UniProtKB=P70424	Receptor tyrosine-protein kinase erbB-2	ISS	8393325	gi	PTHR24416:SF137	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	DROME|FlyBase=FBgn0263111|UniProtKB=P91645	Voltage-dependent calcium channel type A subunit alpha-1	ISS	14507926	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05731	GABA-B receptor II signaling	P05755	Gbeta	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	6264430	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	BRAFL|Gene=BRAFLDRAFT_122664|UniProtKB=C3ZIB9	Putative uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00012	Cadherin signaling pathway	P00474	Wnt	RAT|RGD=1304988|UniProtKB=A0A0G2K6Q8	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00052	TGF-beta signaling pathway	P01275	P38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00056	VEGF signaling pathway	P01417	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02738	De novo purine biosynthesis	P02908	Phosphoribosylamine glycine ligase	RAT|RGD=1308717|UniProtKB=G3V918	Phosphoribosylglycinamide formyltransferase, isoform CRA_a	ISS			PTHR10520:SF10	TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3
P00052	TGF-beta signaling pathway	P01275	P38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	TAS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	DROME|FlyBase=FBgn0004168|UniProtKB=P28285	5-hydroxytryptamine receptor 2A	ISS	12441358	PubMed	PTHR24247:SF117	5-HYDROXYTRYPTAMINE RECEPTOR 2A-RELATED
P06664	Gonadotropin-releasing hormone receptor pathway	P06763	Caveolin-1	MOUSE|MGI=MGI=102709|UniProtKB=P49817	Caveolin-1	RCA	9741627	PubMed	PTHR10844:SF18	CAVEOLIN-1
P00019	Endothelin signaling pathway	P00577	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01275	P38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	TAS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CAEBR|Gene=CBG12686|UniProtKB=A8XGC4	Protein CBR-ACR-11	ISS	11404397	PubMed	PTHR18945:SF436	ACETYLCHOLINE RECEPTOR
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	YARLI|EnsemblGenome=YALI0_D08272g|UniProtKB=Q9UVF3	Actin	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	IDA	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	BOVIN|Ensembl=ENSBTAG00000016552|UniProtKB=A5PK70	Nucleoside diphosphate kinase	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P00018	EGF receptor signaling pathway	P00561	STAT	MACMU|Ensembl=ENSMMUG00000010705|UniProtKB=F7G8V4	Signal transducer and activator of transcription	ISS	96210005	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00021	FGF signaling pathway	P00642	MEK1-2	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00018	EGF receptor signaling pathway	P00552	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	BOVIN|Ensembl=ENSBTAG00000001338|UniProtKB=F1MP16	Uncharacterized protein	ISS			PTHR10489:SF649	C-C CHEMOKINE RECEPTOR TYPE 3
P05918	p38 MAPK pathway	P06020	p38delta	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	THEMA|EnsemblGenome=TM_0118|UniProtKB=G4FH33	Ribonucleotide reductase of class II (Coenzyme B12-dependent)	ISS			PTHR43371:SF1	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01407	Erk	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00373	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IGI	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	MOUSE|MGI=MGI=97514|UniProtKB=P29121	Proprotein convertase subtilisin/kexin type 4	ISS			PTHR42884:SF16	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00059	p53 pathway	P01480	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P02748	Isoleucine biosynthesis	P02994	Branched chain amino acid aminotransferase	METJA|EnsemblGenome=MJ_1008|UniProtKB=Q58414	Putative branched-chain-amino-acid aminotransferase	ISS			PTHR42743:SF3	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE-LIKE PROTEIN 1-RELATED
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MACMU|Ensembl=ENSMMUG00000018272|UniProtKB=F7HEB8	Uncharacterized protein	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IDA	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00037	Ionotropic glutamate receptor pathway	P01015	Glu4	PANTR|Ensembl=ENSPTRG00000004233|UniProtKB=H2Q4N9	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00009	Axon guidance mediated by netrin	P00359	NFAT	HUMAN|HGNC=7776|UniProtKB=Q13469	Nuclear factor of activated T-cells, cytoplasmic 2	IDA	9133421	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00053	T cell activation	P01313	CD28	MOUSE|MGI=MGI=88327|UniProtKB=P31041	T-cell-specific surface glycoprotein CD28	ISS	7534617	PubMed	PTHR11494:SF7	T-CELL-SPECIFIC SURFACE GLYCOPROTEIN CD28
P06664	Gonadotropin-releasing hormone receptor pathway	P06847	JNK1/2	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	RCA	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04561	SRF	XENTR|Xenbase=XB-GENE-482036|UniProtKB=F7BXX1	Uncharacterized protein (Fragment)	ISS	2009862	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00053	T cell activation	P01322	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00951	Jnk	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	ORYSJ|EnsemblGenome=OS02G0834000|UniProtKB=Q6EP31	Rac-like GTP-binding protein 5	ISS	10860831	PubMed	PTHR24072:SF194	RAC-LIKE GTP-BINDING PROTEIN ARAC4-RELATED
P00029	Huntington disease	P00805	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_127490|UniProtKB=C3XYC5	Putative uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00057	Wnt signaling pathway	P01444	Wnt	RAT|RGD=1304559|UniProtKB=D4A3W9	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P00046	Oxidative stress response	P01135	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	TAS	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04393	Ras Pathway	P04569	Cdc42	DANRE|ZFIN=ZDB-GENE-030131-8783|UniProtKB=Q52WY2	Ras-like protein Cdc42a	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00012	Cadherin signaling pathway	P00477	GSK3beta	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CAEEL|WormBase=WBGene00006537|UniProtKB=P52275	Tubulin beta-2 chain	ISS	9454836	PubMed	PTHR11588:SF84	TUBULIN BETA-2 CHAIN
P00030	Hypoxia response via HIF activation	P00819	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	TAS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00036	Interleukin signaling pathway	P00981	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00059	p53 pathway	P04609	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	HUMAN|HGNC=4404|UniProtKB=P59768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IDA	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	RCA	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00036	Interleukin signaling pathway	P00985	PDK1/2	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	ISS	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04393	Ras Pathway	P04542	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06210	Activin beta signaling pathway	P06231	BABO	DROME|FlyBase=FBgn0011300|UniProtKB=A1Z7L8	Receptor protein serine/threonine kinase	IEA	10683140	PubMed	PTHR23255:SF71	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00029	Huntington disease	P00790	beta-Tubulin	ARATH|TAIR=AT5G23860|UniProtKB=P29516	Tubulin beta-8 chain	TAS	12932731	PubMed	PTHR11588:SF264	TUBULIN BETA-8 CHAIN
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00046	Oxidative stress response	P01129	JNK1/2	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02757	O-antigen biosynthesis	P03045	dTDP-glucose 4,6-dehydratase	LEPIN|EnsemblGenome=LA_1661|UniProtKB=Q8F5L7	dTDP-glucose 4,6-dehydratase	ISS			PTHR43000:SF14	DTDP-GLUCOSE 4,6-DEHYDRATASE 2
P04393	Ras Pathway	P04553	PAK	XENTR|Xenbase=XB-GENE-966302|UniProtKB=F6T2E7	Uncharacterized protein	ISS	10644687	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00010	B cell activation	P00381	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01433	SIAH-1	PANTR|Ensembl=ENSPTRG00000008094|UniProtKB=H2QB23	E3 ubiquitin-protein ligase	ISS	14985507	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00034	Integrin signalling pathway	P00907	ERK	PANTR|Ensembl=ENSPTRG00000012427|UniProtKB=H2QIN7	Mitogen-activated protein kinase kinase kinase 2	ISS			PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P06959	CCKR signaling map	P07228	MAPK1/3	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	RCA	9374631	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02723	Adenine and hypoxanthine salvage pathway	P02812	Deoxyinosine phosphorylase	CAEBR|Gene=CBG13501|UniProtKB=A8XI15	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BOVIN|Gene=ACTB|UniProtKB=P60712	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00005	Angiogenesis	P00203	Erk	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IDA	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02728	Arginine biosynthesis	P02841	argininosuccinate lyase	CHICK|Gene=ASL2|UniProtKB=P05083	Argininosuccinate lyase	ISS			PTHR43814:SF1	ARGININOSUCCINATE LYASE
P00005	Angiogenesis	P00210	eNOS	PANTR|Ensembl=ENSPTRG00000019868|UniProtKB=H2QVM2	Nitric oxide synthase	ISS	9837777	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00931	Integrin beta	HUMAN|Ensembl=ENSG00000259753|UniProtKB=H3BM21	Integrin beta (Fragment)	IDA	280842	gi	PTHR10082:SF25	INTEGRIN BETA-3
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00053	T cell activation	P01322	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00375	Calmodulin	ANOGA|EnsemblGenome=AGAP010957|UniProtKB=Q7QGY7	AGAP010957-PA (Fragment)	ISS	9753452	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P02743	Formyltetrahydroformate biosynthesis	P02953	Cobalamin dependent homocysteine transmethylase	ECOLI|EcoGene=EG13343|UniProtKB=Q47690	Homocysteine S-methyltransferase	ISS			PTHR21091:SF123	FI01821P
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00589	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00231	HSP27	CHICK|Ensembl=ENSGALG00000016199|UniProtKB=P02504	Alpha-crystallin A chain	ISS			PTHR11527:SF36	ALPHA-CRYSTALLIN A CHAIN
P00053	T cell activation	P01307	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04398	p53 pathway feedback loops 2	P04658	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00019	Endothelin signaling pathway	P00577	PI3K	DROME|FlyBase=FBgn0015278|UniProtKB=Q7K3H0	LD28067p	IGI	14526383	PubMed	PTHR10048:SF64	LD28067P
P00047	PDGF signaling pathway	P01146	Ikk	MOUSE|MGI=MGI=1338071|UniProtKB=O88351	Inhibitor of nuclear factor kappa-B kinase subunit beta	RCA			PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00021	FGF signaling pathway	P00624	14-3-3	NEUCR|EnsemblGenome=EFNCRG00000002359|UniProtKB=Q7RVK6	14-3-3 family protein 7	ISS	22057342	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	BRAFL|Gene=BRAFLDRAFT_123893|UniProtKB=C3XQF4	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00303	c-Jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00004	Alzheimer disease-presenilin pathway	P00165	E-cadherin N-terminal fragment	RAT|RGD=621089|UniProtKB=F1LMI3	Cadherin 3, type 1, P-cadherin (Placental)	ISS	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00029	Huntington disease	P00810	GAPDH	ORYSJ|EnsemblGenome=OS03G0129300|UniProtKB=Q9SNK3	Glyceraldehyde-3-phosphate dehydrogenase	IPI			PTHR43148:SF1	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE GAPB, CHLOROPLASTIC
P00012	Cadherin signaling pathway	P00475	Frizzled	PANTR|Ensembl=ENSPTRG00000012855|UniProtKB=H2QJA9	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF126	FRIZZLED-5
P00021	FGF signaling pathway	P00643	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IGI	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04393	Ras Pathway	P04557	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IDA	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DANRE|ZFIN=ZDB-GENE-040426-1178|UniProtKB=Q7SY24	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00054	Toll receptor signaling pathway	P01375	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	RCA	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00059	p53 pathway	P04613	B99	MACMU|Ensembl=ENSMMUG00000008136|UniProtKB=F7HGK9	Uncharacterized protein	ISS	12750368	PubMed	PTHR21584:SF10	G2 AND S PHASE-EXPRESSED PROTEIN 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00547	PP2A	RAT|RGD=3380|UniProtKB=P63331	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	IGI	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00131	HAC1	MACMU|Ensembl=ENSMMUG00000007728|UniProtKB=F7C974	RING finger protein 22	ISS			PTHR44028:SF1	TRIPARTITE MOTIF-CONTAINING PROTEIN 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00709	Glycogen synthase D	MOUSE|MGI=MGI=2385254|UniProtKB=Q8VCB3	Glycogen [starch] synthase, liver	IDA	4212312	PubMed	PTHR10176:SF1	GLYCOGEN  STARCH  SYNTHASE, LIVER
P00005	Angiogenesis	P00206	Wnt	ORNAN|Gene=WNT2|UniProtKB=Q07DZ8	Protein Wnt-2	ISS	11266476	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MOUSE|MGI=MGI=99673|UniProtKB=P84309	Adenylate cyclase type 5	ISS	2491850	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00022	General transcription by RNA polymerase I	P00657	TBP	MACMU|Ensembl=ENSMMUG00000023041|UniProtKB=F6VEJ6	Uncharacterized protein	ISS	600075	OMIM	PTHR10126:SF34	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 2
P00052	TGF-beta signaling pathway	P01275	P38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00220	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	12972619	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04585	TRH	PANTR|Ensembl=ENSPTRG00000001144|UniProtKB=H2PZR0	Uncharacterized protein	ISS			PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P00013	Cell cycle	P00481	APC	BOVIN|Gene=ANAPC10|UniProtKB=Q2YDH1	Anaphase-promoting complex subunit 10	ISS	7657035	gi	PTHR12936:SF0	ANAPHASE-PROMOTING COMPLEX SUBUNIT 10
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=69424|UniProtKB=Q99P84	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	12176394	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	IPI	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P06664	Gonadotropin-releasing hormone receptor pathway	P06779	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	RCA	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00922	Collagen	HUMAN|HGNC=14864|UniProtKB=P25940	Collagen alpha-3(V) chain	IDA	10778855	PubMed	PTHR24023:SF567	COLLAGEN ALPHA-3 V  CHAIN
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	NEUCR|EnsemblGenome=EFNCRG00000001945|UniProtKB=Q8TG11	Casein kinase II subunit beta-2	IDA	10617630	PubMed	PTHR22746:SF10	RAB6A-GEF COMPLEX PARTNER PROTEIN 1
P00016	Cytoskeletal regulation by Rho GTPase	P00524	LIMK	PANTR|Ensembl=ENSPTRG00000019286|UniProtKB=H2QUQ8	LIM domain kinase 1	ISS			PTHR44124:SF1	LIM DOMAIN KINASE 1
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MONDO|Ensembl=ENSMODG00000009514|UniProtKB=F7EVK3	Uncharacterized protein	ISS	10487205	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	ISS	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00059	p53 pathway	P01485	p53	CANLF|Ensembl=ENSCAFG00000013961|UniProtKB=F1PL57	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Ensembl=ENSCAFG00000006119|UniProtKB=E2R428	Serine/threonine-protein kinase	ISS	12676944	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	ARATH|TAIR=AT3G11820|UniProtKB=Q9ZSD4	Syntaxin-121	IC			PTHR19957:SF69	SYNTAXIN-121-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	HUMAN|HGNC=1388|UniProtKB=O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	14624853	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00005	Angiogenesis	P00182	p38MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01428	Frizzled	RAT|RGD=628817|UniProtKB=Q8K4C8	Frizzled homolog 9 (Drosophila)	ISS	8717036	PubMed	PTHR11309:SF79	FRIZZLED-9
P00057	Wnt signaling pathway	P01444	Wnt	DANRE|ZFIN=ZDB-GENE-980526-87|UniProtKB=Q92050	Protein Wnt-5b	IDA	11266476	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00810	GAPDH	SYNY3|EnsemblGenome=BAA17609|UniProtKB=P49433	Glyceraldehyde-3-phosphate dehydrogenase 1	ISS			PTHR10836:SF76	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000023202|UniProtKB=F7EU36	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00839	SHIP	MACMU|Ensembl=ENSMMUG00000010451|UniProtKB=F7CRA7	Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2	ISS	10610720	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00048	PI3 kinase pathway	P01177	P110ACT	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04397	p53 pathway by glucose deprivation	P04646	alpha4	HUMAN|HGNC=5461|UniProtKB=P78318	Immunoglobulin-binding protein 1	IDA	9647778	PubMed	PTHR10933:SF9	IMMUNOGLOBULIN-BINDING PROTEIN 1
P00006	Apoptosis signaling pathway	P00269	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01300	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00642	MEK1-2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05915	Opioid proenkephalin pathway	P05994	G-protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DROME|FlyBase=FBgn0001105|UniProtKB=P26308	Guanine nucleotide-binding protein subunit beta-1	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00005	Angiogenesis	P00206	Wnt	RAT|RGD=628850|UniProtKB=B1WBR9	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	TAKRU|Ensembl=ENSTRUG00000008685|UniProtKB=H2TXN3	Uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF326	CALMODULIN
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IDA	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00060	Ubiquitin proteasome pathway	P01491	E2	SCHPO|PomBase=SPAC11E3.04c|UniProtKB=O13685	Ubiquitin-conjugating enzyme E2 13	ISS			PTHR43902:SF2	UBIQUITIN-CONJUGATING ENZYME E2 N
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	TAS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000002297|UniProtKB=F1N167	Uncharacterized protein	ISS			PTHR11824:SF7	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4
P00053	T cell activation	P01309	fos	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	TAS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04395	Vasopressin synthesis	P04597	Signal Peptide	TAKRU|Ensembl=ENSTRUG00000015631|UniProtKB=H2USP0	Uncharacterized protein	ISS	192340	OMIM	PTHR11681:SF14	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00029	Huntington disease	P00790	beta-Tubulin	BOVIN|Ensembl=ENSBTAG00000006969|UniProtKB=Q2KJD0	Tubulin beta-5 chain	ISS	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00025	Hedgehog signaling pathway	P00682	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	RCA			PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	10755300	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00057	Wnt signaling pathway	P01443	Phospholipase C	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IDA	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00053	T cell activation	P01311	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00005	Angiogenesis	P00211	GSK3beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00053	T cell activation	P01330	IKK	PANTR|Ensembl=ENSPTRG00000033948|UniProtKB=H2RBD4	Conserved helix-loop-helix ubiquitous kinase	ISS	14499113	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00047	PDGF signaling pathway	P01153	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00057	Wnt signaling pathway	P01438	PP2A	CHICK|Ensembl=ENSGALG00000010273|UniProtKB=P48463	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	IDA	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04494	TSC2	BOVIN|Ensembl=ENSBTAG00000020617|UniProtKB=E1BNT2	Uncharacterized protein	ISS	12150915	PubMed	PTHR10063:SF0	TUBERIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	ISS	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04371	5-Hydroxytryptamine biosynthesis	P04399	Tryptophan hydroxylase	BOVIN|Ensembl=ENSBTAG00000020792|UniProtKB=E1BGX6	Uncharacterized protein	ISS	14597720	PubMed	PTHR11473:SF16	TRYPTOPHAN 5-HYDROXYLASE 2
P00050	Plasminogen activating cascade	P01263	pro-MMP-1	HUMAN|HGNC=7155|UniProtKB=P03956	Interstitial collagenase	IGI	12834808	PubMed	PTHR10201:SF151	INTERSTITIAL COLLAGENASE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05731	GABA-B receptor II signaling	P05755	Gbeta	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01425	PKC	DROME|Gene=Dmel_CG7125|UniProtKB=A0A0B4KHC3	Serine/threonine-protein kinase	ISS			PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P00036	Interleukin signaling pathway	P00962	ELK	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	IC	12660819	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04586	ProTRH (Pro Thyrotropin-releasing Hormone)	HUMAN|HGNC=12372|UniProtKB=P01222	Thyrotropin subunit beta	ISS			PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00964	p90RSK	MONDO|Ensembl=ENSMODG00000008086|UniProtKB=F6YJ34	Ribosomal protein S6 kinase	ISS	10480933	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00034	Integrin signalling pathway	P00924	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P02772	Pyruvate metabolism	P03141	Citrate Synthetase	PYRAE|EnsemblGenome=PAE3584|UniProtKB=Q8ZSU1	Citrate synthase (unknown stereospecificity)	IEA	11792869	PubMed	PTHR11739:SF8	CITRATE SYNTHASE, MITOCHONDRIAL
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=18539|UniProtKB=P61266	Syntaxin-1B	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	PANTR|Ensembl=ENSPTRG00000018607|UniProtKB=H2QTR3	Syntaxin 7	ISS	10321247	PubMed	PTHR19957:SF90	SYNTAXIN-7
P00036	Interleukin signaling pathway	P00981	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P02756	N-acetylglucosamine metabolism	P03041	Glucosamine-6-phosphate deaminase	ECOLI|EcoGene=EG12772|UniProtKB=P42912	Putative galactosamine-6-phosphate isomerase	ISS			PTHR11280:SF5	GLUCOSAMINE-6-PHOSPHATE ISOMERASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04398	p53 pathway feedback loops 2	P04665	AKT	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	ISS	12089061	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	BOVIN|Ensembl=ENSBTAG00000018705|UniProtKB=F1MPC9	Uncharacterized protein	ISS	12623444	PubMed	PTHR11920:SF291	ADENYLATE CYCLASE TYPE 3
P00047	PDGF signaling pathway	P01145	c-fos	TAKRU|Ensembl=ENSTRUG00000010579|UniProtKB=H2TPU7	Uncharacterized protein	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00048	PI3 kinase pathway	P01199	Galpha	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	IC	1650351	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MONDO|Ensembl=ENSMODG00000001384|UniProtKB=F7GL73	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00005	Angiogenesis	P00236	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00307	ELF2alpha	TAKRU|Ensembl=ENSTRUG00000017958|UniProtKB=H2V9Z7	Uncharacterized protein	ISS			PTHR10602:SF0	EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00021	FGF signaling pathway	P00624	14-3-3	ARATH|TAIR=AT1G22290|UniProtKB=F4I1B7	14-3-3 family protein	ISS			PTHR18860:SF32	14-3-3 FAMILY PROTEIN-RELATED
P00004	Alzheimer disease-presenilin pathway	P00168	E-cadherin intracellular fragment	MOUSE|MGI=MGI=88356|UniProtKB=P10287	Cadherin-3	IDA	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P04393	Ras Pathway	P04556	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	IDA	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04393	Ras Pathway	P04578	Rho	TAKRU|Ensembl=ENSTRUG00000011944|UniProtKB=H2TZX5	Uncharacterized protein	ISS	10556059	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P02728	Arginine biosynthesis	P02846	Ornithine carbamoyl transferase	MACMU|Ensembl=ENSMMUG00000013493|UniProtKB=F6ZKS9	Uncharacterized protein	ISS			PTHR11405:SF1	ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	STRPU|EnsemblGenome=SPU_025182|UniProtKB=W4ZAK5	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00807	Actin	ARATH|TAIR=AT3G18780|UniProtKB=Q96292	Actin-2	IDA	11889126	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00005	Angiogenesis	P00182	p38MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02727	Androgen/estrogene/progesterone biosynthesis	P02828	Aromatase	CHICK|Gene=CYP19A1|UniProtKB=P19098	Aromatase	ISS	1939054	PubMed	PTHR24291:SF43	AROMATASE
P00036	Interleukin signaling pathway	P00972	MNK1/2	HUMAN|HGNC=7111|UniProtKB=Q9HBH9	MAP kinase-interacting serine/threonine-protein kinase 2	IC	11463832	PubMed	PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P02785	Valine biosynthesis	P03216	Acetolactate synthase	PSEAE|EnsemblGenome=PA4977|UniProtKB=Q9HUI8	Probable 2-ketoarginine decarboxylase AruI	ISS			PTHR18968:SF128	ACETOLACTATE SYNTHASE ISOZYME 1 LARGE SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00200	Dsh	CANLF|Ensembl=ENSCAFG00000012180|UniProtKB=F1PIB1	Uncharacterized protein	ISS	10409711	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00005	Angiogenesis	P00182	p38MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	IDA	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IC	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P02738	De novo purine biosynthesis	P02899	GMP synthase	HALSA|EnsemblGenome=VNG_1829G|UniProtKB=Q9HP33	GMP synthase [glutamine-hydrolyzing] subunit B	ISS			PTHR11922:SF2	GMP SYNTHASE  GLUTAMINE-HYDROLYZING
P00059	p53 pathway	G01563	MDM-2	MACMU|Ensembl=ENSMMUG00000011236|UniProtKB=F6WXF0	Uncharacterized protein	ISS			PTHR13844:SF20	PROTEIN MDM4
P02776	Serine glycine biosynthesis	P03160	Phosphoglycerate dehydrogenase	THEMA|EnsemblGenome=TM_0327|UniProtKB=Q9WYG2	D-3-phosphoglycerate dehydrogenase	ISS			PTHR42938:SF9	FORMATE DEHYDROGENASE 1-RELATED
P05918	p38 MAPK pathway	P06031	p38alpha	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	RCA	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00034	Integrin signalling pathway	P00931	Integrin beta	HUMAN|Ensembl=ENSG00000259753|UniProtKB=H3BM21	Integrin beta (Fragment)	IDA	20069419	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P02785	Valine biosynthesis	P03215	Branched chain amino acid aminotransferase	MACMU|Ensembl=ENSMMUG00000012223|UniProtKB=F6VFZ3	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF51	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, CYTOSOLIC
P00059	p53 pathway	P01486	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02916	dTMP kinase	SCHPO|PomBase=SPCC70.07c|UniProtKB=P36590	Thymidylate kinase	ISS			PTHR10344:SF1	THYMIDYLATE KINASE
P00006	Apoptosis signaling pathway	P00321	HSP70	RAT|RGD=621725|UniProtKB=P63018	Heat shock cognate 71 kDa protein	ISS	12150907	PubMed	PTHR19375:SF239	HEAT SHOCK COGNATE 71 KDA PROTEIN
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	BOVIN|Ensembl=ENSBTAG00000047062|UniProtKB=G3MX13	Uncharacterized protein	ISS	11907044	PubMed	PTHR44062:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 3
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	ARATH|TAIR=AT4G34340|UniProtKB=Q9SYZ9	Transcription initiation factor TFIID subunit 8	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	MONDO|Ensembl=ENSMODG00000019001|UniProtKB=F7CP86	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P02763	Peptidoglycan biosynthesis	P03087	Glutamate racemase	AQUAE|EnsemblGenome=aq_325|UniProtKB=O66662	Glutamate racemase	ISS			PTHR21198:SF2	GLUTAMATE RACEMASE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00008	Axon guidance mediated by Slit/Robo	P00352	DCC	PANTR|Ensembl=ENSPTRG00000010031|UniProtKB=H2QEJ8	Uncharacterized protein	ISS	12798294	PubMed	PTHR44146:SF3	NETRIN RECEPTOR DCC
P00029	Huntington disease	P00790	beta-Tubulin	PLAF7|EnsemblGenome=PF10_0084|UniProtKB=Q7KQL5	Tubulin beta chain	TAS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00019	Endothelin signaling pathway	P00586	Gq	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IGI	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00054	Toll receptor signaling pathway	P01352	p38	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00059	p53 pathway	P04614	Cyclin B	HUMAN|HGNC=1579|UniProtKB=P14635	G2/mitotic-specific cyclin-B1	ISS	1019642	gi	PTHR10177:SF193	G2/MITOTIC-SPECIFIC CYCLIN-B1
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00644	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00021	FGF signaling pathway	P00640	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	PANTR|Ensembl=ENSPTRG00000019361|UniProtKB=H2QUV3	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00021	FGF signaling pathway	P00648	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04397	p53 pathway by glucose deprivation	P04639	AMPK	XENTR|Xenbase=XB-GENE-946195|UniProtKB=F6XJN6	Uncharacterized protein	ISS			PTHR24343:SF306	5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1
P00029	Huntington disease	P00774	Dynein complex	PANTR|Ensembl=ENSPTRG00000012761|UniProtKB=H2QJ64	Uncharacterized protein	ISS	9454836	PubMed	PTHR10676:SF310	DYNEIN HEAVY CHAIN 7, AXONEMAL
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	HUMAN|HGNC=5287|UniProtKB=P28222	5-hydroxytryptamine receptor 1B	ISS	12181435	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00539	14-3-3	MACMU|Ensembl=ENSMMUG00000013206|UniProtKB=F6XFG9	14-3-3 protein beta/alpha	ISS	1671102	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04557	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00047	PDGF signaling pathway	P01173	STAT	DANRE|ZFIN=ZDB-GENE-980526-499|UniProtKB=Q6P943	Signal transducer and activator of transcription	ISS	10417824	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00012	Cadherin signaling pathway	P00470	F-actin	ORYSJ|EnsemblGenome=OS03G0718100|UniProtKB=Q10DV7	Actin-1	IC	11889126	PubMed	PTHR11937:SF364	ACTIN-11
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00003	Alzheimer disease-amyloid secretase pathway	P00092	TACE	BOVIN|Ensembl=ENSBTAG00000001141|UniProtKB=G3MZB3	Uncharacterized protein	ISS	12834808	PubMed	PTHR11905:SF171	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	PANTR|Ensembl=ENSPTRG00000010806|UniProtKB=H2QG00	Low density lipoprotein receptor-related protein 3	ISS	11907044	PubMed	PTHR44062:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	RAT|RGD=3381|UniProtKB=P62716	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	CAEEL|WormBase=WBGene00007653|UniProtKB=Q93244	Cysteine synthase 1	ISS			PTHR10314:SF131	CYSTEINE SYNTHASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00035	Interferon-gamma signaling pathway	P00960	PTP	CHICK|Ensembl=ENSGALG00000004821|UniProtKB=Q90687	Tyrosine-protein phosphatase non-receptor type 11	TAS	1382983	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00059	p53 pathway	P01480	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04393	Ras Pathway	P04570	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00775	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	PANTR|Ensembl=ENSPTRG00000006510|UniProtKB=H2Q8K1	Presenilin	ISS	12736250	PubMed	PTHR10202:SF18	PRESENILIN-1
P00047	PDGF signaling pathway	P01162	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	90172230	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CAEEL|WormBase=WBGene00001612|UniProtKB=P34299	Glutamate receptor 1	IC	10331083	PubMed	PTHR18966:SF297	GLUTAMATE RECEPTOR 1
P00006	Apoptosis signaling pathway	P00318	PKCs	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	IGI	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00030	Hypoxia response via HIF activation	P00819	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04571	Tiam1	BOVIN|Ensembl=ENSBTAG00000017839|UniProtKB=F1MX58	Uncharacterized protein	ISS	11130063	PubMed	PTHR22826:SF88	T-LYMPHOMA INVASION AND METASTASIS-INDUCING PROTEIN 1
P00021	FGF signaling pathway	P00636	FGFR1-4	MACMU|Ensembl=ENSMMUG00000022478|UniProtKB=F7A4U3	Fibroblast growth factor receptor	ISS	12799194	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P04397	p53 pathway by glucose deprivation	P04644	TSC2	CANLF|Ensembl=ENSCAFG00000019438|UniProtKB=F1Q054	Uncharacterized protein	ISS	12150915	PubMed	PTHR10063:SF0	TUBERIN
P06664	Gonadotropin-releasing hormone receptor pathway	P06836	PG Rcs	MOUSE|MGI=MGI=97795|UniProtKB=P30557	Prostaglandin E2 receptor EP3 subtype	RCA	14607241	PubMed	PTHR11866:SF10	PROSTAGLANDIN E2 RECEPTOR EP3 SUBTYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=1953|UniProtKB=P08173	Muscarinic acetylcholine receptor M4	IDA	91373358	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P02759	Pyridoxal-5-phosphate biosynthesis	P03062	1-Deoxyxylulose-5-phosphate synthase	BACSU|EnsemblGenome=BSU24270|UniProtKB=P54523	1-deoxy-D-xylulose-5-phosphate synthase	ISS			PTHR43322:SF5	1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE 1-RELATED
P04398	p53 pathway feedback loops 2	P04661	PI3K	ANOGA|Gene=AgaP_AGAP010273|UniProtKB=Q7PMF0	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	RAT|RGD=2343|UniProtKB=P08483	Muscarinic acetylcholine receptor M3	TAS	12915051	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02788	Xanthine and guanine salvage pathway	P03248	Deoxyguanosine phosphorylase	HUMAN|HGNC=7892|UniProtKB=P00491	Purine nucleoside phosphorylase	ISS			PTHR11904:SF12	PURINE NUCLEOSIDE PHOSPHORYLASE
P00019	Endothelin signaling pathway	P00590	IP3 R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P06959	CCKR signaling map	G07283	MOB1	HUMAN|HGNC=16015|UniProtKB=Q9H8S9	MOB kinase activator 1A	RCA	10666030	PubMed	PTHR22599:SF30	MOB KINASE ACTIVATOR 1A
P00054	Toll receptor signaling pathway	P01375	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01143	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01324	rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	IDA	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00014	Cholesterol biosynthesis	P00498	Hydroxymethyl glutaryl CoA synthase	CHICK|Gene=HMGCS1|UniProtKB=P23228	Hydroxymethylglutaryl-CoA synthase, cytoplasmic	ISS			PTHR43323:SF4	HYDROXYMETHYLGLUTARYL-COA SYNTHASE, CYTOPLASMIC
P00010	B cell activation	P00398	IP3R	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	IGI	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=4404|UniProtKB=P59768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00021	FGF signaling pathway	P00627	ERK1-2	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	MACMU|Ensembl=ENSMMUG00000010173|UniProtKB=F7AGU8	Presenilin	ISS	12736250	PubMed	PTHR10202:SF18	PRESENILIN-1
P00006	Apoptosis signaling pathway	P00322	Cytochrome C	PHANO|EnsemblGenome=SNOG_15669|UniProtKB=Q0TY36	Uncharacterized protein	ISS	1646338	PubMed	PTHR11961:SF12	CYTOCHROME C
P00010	B cell activation	P00381	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	IGI	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000022319|UniProtKB=F6XDA0	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00001	Adrenaline and noradrenaline biosynthesis	P00063	DBH	RAT|RGD=2489|UniProtKB=Q05754	Dopamine beta-hydroxylase	ISS	90219125	PubMed	PTHR10157:SF29	DOPAMINE BETA-HYDROXYLASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	BOVIN|Gene=RPS6KB1|UniProtKB=Q6TJY3	Ribosomal protein S6 kinase beta-1	ISS	11861821	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00005	Angiogenesis	P00190	RasGAP	ORNAN|Ensembl=ENSOANG00000014753|UniProtKB=F7EPN2	Uncharacterized protein (Fragment)	ISS	15489039	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00053	T cell activation	P01312	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	SULSO|EnsemblGenome=SSO3203|UniProtKB=Q97U22	Acetyl-CoA synthetase (Acetate-CoA ligase) (AcsA-10)	ISS			PTHR24095:SF232	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	CANLF|Gene=HTR2C|UniProtKB=Q60F97	5-hydroxytryptamine receptor 2C	ISS	8143856	PubMed	PTHR24247:SF32	5-HYDROXYTRYPTAMINE RECEPTOR 2C
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04393	Ras Pathway	P04552	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00021	FGF signaling pathway	P00634	MEKK1-5	PANTR|Ensembl=ENSPTRG00000024326|UniProtKB=H2R231	Uncharacterized protein	ISS	12968034	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00053	T cell activation	P01300	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IDA	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04393	Ras Pathway	P04544	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8617307	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04393	Ras Pathway	P04570	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MOUSE|MGI=MGI=104558|UniProtKB=P18653	Ribosomal protein S6 kinase alpha-1	ISS	12769834	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01136	Elk-1	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	TAS	11279280	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00037	Ionotropic glutamate receptor pathway	P01006	NR2C	HUMAN|HGNC=4587|UniProtKB=Q14957	Glutamate receptor ionotropic, NMDA 2C	ISS	14698601	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00034	Integrin signalling pathway	P00927	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	8649368	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g210933|UniProtKB=A7SEA7	Predicted protein	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00006	Apoptosis signaling pathway	P00269	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MONDO|Ensembl=ENSMODG00000018065|UniProtKB=F7G485	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00018	EGF receptor signaling pathway	P00563	Gab	HUMAN|HGNC=14458|UniProtKB=Q9UQC2	GRB2-associated-binding protein 2	IGI	15356145	PubMed	PTHR12156:SF4	GRB2-ASSOCIATED-BINDING PROTEIN 2
P00010	B cell activation	P00373	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	IGI	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00554	Shc	PANTR|Ensembl=ENSPTRG00000021091|UniProtKB=H2QXF3	Uncharacterized protein	ISS	96404502	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P04387	Histamine synthesis	P04493	Histidine decarboxylase	HUMAN|HGNC=4855|UniProtKB=P19113	Histidine decarboxylase	ISS	1702422	PubMed	PTHR11999:SF68	HISTIDINE DECARBOXYLASE
P00021	FGF signaling pathway	P00629	PP2A	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00376	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P02731	Biotin biosynthesis	P02857	Biotin synthase	STRCO|EnsemblGenome=CAC01468|UniProtKB=Q9FCC3	Biotin synthase	ISS			PTHR22976:SF1	BIOTIN SYNTHASE, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CAEEL|WormBase=WBGene00004036|UniProtKB=G5EFI8	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P02756	N-acetylglucosamine metabolism	P03036	N-acetylglucosamine-6-phosphate deacetylase	PSEAE|EnsemblGenome=PA3758|UniProtKB=Q9HXN7	N-acetylglucosamine-6-phosphate deacetylase	ISS			PTHR11113:SF1	N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IDA	7925653	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00477	GSK3beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00049	Parkinson disease	P01224	UbcH7	MOUSE|MGI=MGI=109240|UniProtKB=P68037	Ubiquitin-conjugating enzyme E2 L3	ISS	10888878	PubMed	PTHR24068:SF67	UBIQUITIN-CONJUGATING ENZYME E2 L3
P05917	Opioid proopiomelanocortin pathway	P06011	AC	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P04393	Ras Pathway	P04555	PDK	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	IDA	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P02724	Alanine biosynthesis	P02815	Branched chain amino acid aminotransferase	MYCTU|EnsemblGenome=Rv2210c|UniProtKB=P9WQ75	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF44	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P00010	B cell activation	P00373	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00025	Hedgehog signaling pathway	P00692	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00006	Apoptosis signaling pathway	P00274	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00049	Parkinson disease	P01242	Casein kinase I	XENTR|Xenbase=XB-GENE-481480|UniProtKB=Q5XGI6	Casein kinase 1, epsilon	ISS	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00055	Transcription regulation by bZIP transcription factor	P01391	TFIIFalpha	BOVIN|Ensembl=ENSBTAG00000021016|UniProtKB=Q5EA53	General transcription factor IIF subunit 1	ISS	12732728	PubMed	PTHR13011:SF0	GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	NEUCR|EnsemblGenome=EFNCRG00000003892|UniProtKB=Q9UUY8	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00019	Endothelin signaling pathway	P00566	ERK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	NAS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00057	Wnt signaling pathway	P01452	NFAT	MACMU|Ensembl=ENSMMUG00000012657|UniProtKB=F7E7J1	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00047	PDGF signaling pathway	P01152	RasGAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	227170	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	ANOGA|EnsemblGenome=AGAP009624|UniProtKB=Q7Q1U7	CTP synthase (Fragment)	ISS			PTHR11550:SF0	CTP SYNTHASE
P00020	FAS signaling pathway	P00611	Gelsolin	BOVIN|Gene=GSN|UniProtKB=Q3SX14	Gelsolin	ISS	9323209	PubMed	PTHR11977:SF29	GELSOLIN
P00021	FGF signaling pathway	P00632	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	1333286	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00034	Integrin signalling pathway	P00921	PINCH	PANTR|Ensembl=ENSPTRG00000012432|UniProtKB=H2QIP1	Uncharacterized protein	ISS	10022929	PubMed	PTHR24210:SF10	LIM AND SENESCENT CELL ANTIGEN-LIKE-CONTAINING DOMAIN PROTEIN 2
P00034	Integrin signalling pathway	P00936	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IPI	129387	gi	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P05918	p38 MAPK pathway	P06020	p38delta	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00010	B cell activation	P00375	Calmodulin	HUMAN|HGNC=1442|UniProtKB=P62158	Calmodulin	IDA	9753452	PubMed	PTHR23050:SF311	CALMODULIN
P00052	TGF-beta signaling pathway	P01292	RSmads	PANTR|Ensembl=ENSPTRG00000007199|UniProtKB=H2Q9N8	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF25	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3
P00019	Endothelin signaling pathway	P00577	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	ORNAN|Ensembl=ENSOANG00000006119|UniProtKB=F6WTY3	Uncharacterized protein	ISS			PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CAEBR|Gene=CBG17587|UniProtKB=A8XRA5	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00291	MEKK1	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	ISS	8643568	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Ensembl=ENSCAFG00000007780|UniProtKB=F1PZH9	Uncharacterized protein	ISS	1608964	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	ARATH|TAIR=AT2G42100|UniProtKB=Q8RYC2	Putative actin-5	IC	14684598	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00034	Integrin signalling pathway	P00948	Rho	BOVIN|Ensembl=ENSBTAG00000004279|UniProtKB=P61585	Transforming protein RhoA	ISS	12169092	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P04398	p53 pathway feedback loops 2	P04651	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00034	Integrin signalling pathway	P00951	Jnk	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00214	HIF-1	BOVIN|Gene=HIF1A|UniProtKB=Q9XTA5	Hypoxia-inducible factor 1-alpha	ISS	9606183	PubMed	PTHR23043:SF7	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA
P00048	PI3 kinase pathway	P01192	p110	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00024	Glycolysis	P00679	Aldolase	HUMAN|HGNC=414|UniProtKB=P04075	Fructose-bisphosphate aldolase A	ISS	74094688	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P02785	Valine biosynthesis	P03217	Dihydroxy isovalerate reductoisomerase	DEIRA|EnsemblGenome=DR_1519|UniProtKB=Q9RU74	Ketol-acid reductoisomerase	ISS			PTHR21371:SF1	KETOL-ACID REDUCTOISOMERASE, CHLOROPLASTIC
P00019	Endothelin signaling pathway	P00568	PKC	DANRE|ZFIN=ZDB-GENE-040426-1178|UniProtKB=Q7SY24	Protein kinase C beta type	ISS	11880265	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P02747	Histidine biosynthesis	P02987	ATP phosphoribosyl transferase	NEUCR|EnsemblGenome=EFNCRG00000009117|UniProtKB=Q7SDF1	ATP phosphoribosyltransferase	ISS			PTHR21403:SF0	ATP PHOSPHORIBOSYLTRANSFERASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ORYSJ|EnsemblGenome=OS11G0163100|UniProtKB=Q67G20	Actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00018	EGF receptor signaling pathway	P00559	MEK1-2	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	CHICK|Ensembl=ENSGALG00000009320|UniProtKB=Q4JIM4	Presenilin-1	IDA	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	DANRE|ZFIN=ZDB-GENE-040718-93|UniProtKB=Q6DGZ5	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	SYNY3|Gene=BAA16875|UniProtKB=P72859	Aspartate transaminase	ISS			PTHR42832:SF2	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00193	SOS-1	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS			PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00224	PDGF	XENTR|Xenbase=XB-GENE-484495|UniProtKB=F6WRD7	Uncharacterized protein	ISS			PTHR11633:SF3	PLATELET-DERIVED GROWTH FACTOR SUBUNIT A
P00036	Interleukin signaling pathway	P00985	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	12855688	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00051	TCA cycle	P01266	Pyruvate Dehydrogenase	HUMAN|HGNC=8810|UniProtKB=Q15119	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	TAS			PTHR11947:SF15	PYRUVATE DEHYDROGENASE  ACETYL-TRANSFERRING   KINASE ISOZYME 2, MITOCHONDRIAL
P00047	PDGF signaling pathway	P01160	IP3 receptor	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	ISS	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00012	Cadherin signaling pathway	P00470	F-actin	DANRE|ZFIN=ZDB-GENE-030131-172|UniProtKB=Q6IQR3	Actin, alpha, cardiac muscle 1a	IC	10974003	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04397	p53 pathway by glucose deprivation	P04641	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01428	Frizzled	HUMAN|HGNC=4043|UniProtKB=Q13467	Frizzled-5	IDA	8717036	PubMed	PTHR11309:SF126	FRIZZLED-5
P00018	EGF receptor signaling pathway	P00562	p38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IGI	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04665	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00566	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00054	Toll receptor signaling pathway	P01358	ERK1	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00052	TGF-beta signaling pathway	P01275	P38	CAEBR|Gene=CBG01555|UniProtKB=A8WRD7	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00019	Endothelin signaling pathway	P00572	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IGI	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04393	Ras Pathway	P04547	Ras	MONDO|Ensembl=ENSMODG00000025248|UniProtKB=F7F5X1	Uncharacterized protein	ISS	99084794	PubMed	PTHR24070:SF186	GTPASE KRAS
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00006	Apoptosis signaling pathway	P00274	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	11535291	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	90172230	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00059	p53 pathway	P04633	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00391	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00912	Arp2/3	PANTR|Ensembl=ENSPTRG00000005438|UniProtKB=H2RBJ1	Actin-related protein 2/3 complex subunit 3	ISS	12473693	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P05918	p38 MAPK pathway	P06027	CREB	CHICK|Ensembl=ENSGALG00000008494|UniProtKB=Q7SX83	CAMP response element-binding protein	ISS	11390664	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00021	FGF signaling pathway	P00627	ERK1-2	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	MACMU|Ensembl=ENSMMUG00000017431|UniProtKB=F7HPP3	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00702	CPB	MONDO|Ensembl=ENSMODG00000015970|UniProtKB=F7FD05	Uncharacterized protein	ISS			PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	BOVIN|Ensembl=ENSBTAG00000005660|UniProtKB=P56701	26S proteasome non-ATPase regulatory subunit 2	ISS			PTHR10943:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00628	JNK1-3	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00034	Integrin signalling pathway	P00936	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00020	FAS signaling pathway	P00608	Pro-Caspase3	MACMU|Ensembl=ENSMMUG00000012053|UniProtKB=F7HFY2	Uncharacterized protein	ISS	7983002	PubMed	PTHR10454:SF198	CASPASE-3
P05918	p38 MAPK pathway	P06037	TAK1	PANTR|Ensembl=ENSPTRG00000018427|UniProtKB=H2RCY2	Mitogen-activated protein kinase kinase kinase 7	ISS	10683140	PubMed	PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	CHICK|Ensembl=ENSGALG00000027629|UniProtKB=Q5ZJ03	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00030	Hypoxia response via HIF activation	P00823	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00030	Hypoxia response via HIF activation	P00819	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00053	T cell activation	P01295	vav	MOUSE|MGI=MGI=102718|UniProtKB=Q60992	Guanine nucleotide exchange factor VAV2	IGI	14623913	PubMed	PTHR22826:SF95	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV2
P04393	Ras Pathway	P04556	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	12068308	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P02763	Peptidoglycan biosynthesis	P03083	UDP-N-acetylmuramoylalanine-D-glutamate ligase	AQUAE|EnsemblGenome=aq_2075|UniProtKB=O67852	UDP-N-acetylmuramoylalanine--D-glutamate ligase	ISS			PTHR43692:SF1	UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE
P00006	Apoptosis signaling pathway	P00303	c-Jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	2837282	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	HUMAN|HGNC=1401|UniProtKB=Q02641	Voltage-dependent L-type calcium channel subunit beta-1	IC	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00019	Endothelin signaling pathway	P00570	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IDA	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MACMU|Ensembl=ENSMMUG00000001353|UniProtKB=F7D6T8	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00029	Huntington disease	P00786	ARF	MOUSE|MGI=MGI=99595|UniProtKB=Q8BSL7	ADP-ribosylation factor 2	IPI	12932731	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00021	FGF signaling pathway	P00648	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	IGI	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000025240|UniProtKB=F7A7I3	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	MYCTU|EnsemblGenome=Rv2764c|UniProtKB=P9WFR9	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P02743	Formyltetrahydroformate biosynthesis	P02952	Methylene tetrahydrofolate dehydrogenase	PANTR|Ensembl=ENSPTRG00000018710|UniProtKB=H2QTW9	Uncharacterized protein	ISS			PTHR43274:SF3	MONOFUNCTIONAL C1-TETRAHYDROFOLATE SYNTHASE, MITOCHONDRIAL
P00036	Interleukin signaling pathway	P00997	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	7680960	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00029	Huntington disease	P00807	Actin	RAT|RGD=1310826|UniProtKB=Q5M7U6	Actin-related protein 2	ISS	10974003	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	PANTR|Ensembl=ENSPTRG00000004718|UniProtKB=H2Q5I0	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IDA	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000009939|UniProtKB=H2QED9	Cadherin 2, type 1, N-cadherin (Neuronal)	ISS	8120095	PubMed	PTHR24027:SF79	CADHERIN-2
P00011	Blood coagulation	P00448	vWF	HUMAN|HGNC=12726|UniProtKB=P04275	von Willebrand factor	ISS	193400	OMIM	PTHR11339:SF361	VON WILLEBRAND FACTOR-RELATED
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	CAEBR|Gene=CBG20737|UniProtKB=A8XYH6	Protein CBR-GLN-2	ISS			PTHR20852:SF57	GLUTAMINE SYNTHETASE 2 CYTOPLASMIC
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05963	MAO	BOVIN|Ensembl=ENSBTAG00000016206|UniProtKB=P21398	Amine oxidase [flavin-containing] A	ISS	90344230	PubMed	PTHR43563:SF3	AMINE OXIDASE  FLAVIN-CONTAINING  A
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PHYPA|Gene=PHYPADRAFT_107830|UniProtKB=A9TBG2	Actin 7	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00048	PI3 kinase pathway	P01178	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	11384839	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P05913	Enkephalin release	P05972	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00023	General transcription regulation	P00658	TBP-associated factors	SCHPO|PomBase=SPAC13F5.02c|UniProtKB=O13701	Transcription initiation factor TFIID subunit 7	ISS			PTHR12228:SF0	TAF7 RNA POLYMERASE II, TATA BOX BINDING PROTEIN  TBP -ASSOCIATED FACTOR
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	DANRE|ZFIN=ZDB-GENE-030131-6206|UniProtKB=F1Q5K4	Uncharacterized protein	IC	89264452	PubMed	PTHR13140:SF676	MYOSIN, HEAVY POLYPEPTIDE 2, FAST MUSCLE SPECIFIC
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CAEBR|Gene=CBG17587|UniProtKB=A8XRA5	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P06959	CCKR signaling map	P07031	p70S6K1	HUMAN|HGNC=10436|UniProtKB=P23443	Ribosomal protein S6 kinase beta-1	RCA	9299479	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	10218114	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P02773	S-adenosylmethionine biosynthesis	P03142	Cobalamin-dependent homocysteine transmethylase	SYNY3|EnsemblGenome=BAA10438|UniProtKB=Q55786	Methionine synthase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	7667318	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00010	B cell activation	P00379	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00029	Huntington disease	P00799	JNK-2	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IDA	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00840	GPRK	HUMAN|HGNC=4545|UniProtKB=P43250	G protein-coupled receptor kinase 6	IDA	12032308	PubMed	PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00059	p53 pathway	P01485	p53	PANTR|Ensembl=ENSPTRG00000008703|UniProtKB=H2QC53	Cellular tumor antigen p53	ISS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	BOVIN|Ensembl=ENSBTAG00000013498|UniProtKB=Q75Z89	5-hydroxytryptamine receptor 2A	ISS	11859080	PubMed	PTHR24247:SF30	5-HYDROXYTRYPTAMINE RECEPTOR 2A
P05913	Enkephalin release	P05977	G-Protein (s)	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01067	AChE	CANLF|Ensembl=ENSCAFG00000014054|UniProtKB=E2RP98	Carboxylic ester hydrolase	ISS	86008285	PubMed	PTHR11559:SF356	ACETYLCHOLINESTERASE
P00053	T cell activation	P01332	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02738	De novo purine biosynthesis	P02902	ADP reductase	CHICK|Ensembl=ENSGALG00000017350|UniProtKB=E1C4Q0	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P05913	Enkephalin release	P05972	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00036	Interleukin signaling pathway	P00976	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BRAFL|Gene=BRAFLDRAFT_104698|UniProtKB=C3XYW6	Protein Wnt (Fragment)	TAS	11266476	PubMed	PTHR12027:SF81	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000018059|UniProtKB=C7G3M9	Glutamate receptor, metabotropic 4	ISS	11431030	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DANRE|ZFIN=ZDB-GENE-040426-1178|UniProtKB=Q7SY24	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00796	Kainate receptor	CANLF|Ensembl=ENSCAFG00000004930|UniProtKB=E2RFB5	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00828	Galphai	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	RCA			PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00059	p53 pathway	P04623	CBP	XENTR|Xenbase=XB-GENE-6258723|UniProtKB=F6UDV6	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00012	Cadherin signaling pathway	P00470	F-actin	PHYIT|EnsemblGenome=PITG_15117|UniProtKB=D0NRP9	Actin-like protein	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00038	JAK/STAT signaling pathway	P01027	STAT	HUMAN|HGNC=11362|UniProtKB=P42224	Signal transducer and activator of transcription 1-alpha/beta	ISS	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	TAKRU|Ensembl=ENSTRUG00000014318|UniProtKB=H2UI49	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IDA	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00632	Akt	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	IGI	22084520	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00384	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	ISS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	TAS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	RAT|RGD=61863|UniProtKB=P19493	Glutamate receptor 4	ISS	12941441	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00057	Wnt signaling pathway	P01465	Ggamma	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00059	p53 pathway	P04616	PDK1/2	DROME|FlyBase=FBgn0020386|UniProtKB=Q9W0V1	3-phosphoinositide-dependent protein kinase 1	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04393	Ras Pathway	P04542	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9060|UniProtKB=P51178	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	10934033	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00037	Ionotropic glutamate receptor pathway	P01005	NR2D	HUMAN|HGNC=4588|UniProtKB=O15399	Glutamate receptor ionotropic, NMDA 2D	ISS	11319238	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00021	FGF signaling pathway	P00629	PP2A	DANRE|ZFIN=ZDB-GENE-030904-6|UniProtKB=Q7ZUQ2	Ppp2r5e1 protein	ISS	8703017	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	TAKRU|Ensembl=ENSTRUG00000011358|UniProtKB=H2TVF7	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF751	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01275	P38	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	TAS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00036	Interleukin signaling pathway	P00997	Shc	MOUSE|MGI=MGI=98296|UniProtKB=P98083	SHC-transforming protein 1	IGI	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00012	Cadherin signaling pathway	P00465	TCF/LEF	BOVIN|Ensembl=ENSBTAG00000010111|UniProtKB=F1MJS2	Uncharacterized protein	ISS	12356903	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00006	Apoptosis signaling pathway	P00321	HSP70	RAT|RGD=1593284|UniProtKB=P0DMW0	Heat shock 70 kDa protein 1A	ISS	12150907	PubMed	PTHR19375:SF223	HEAT SHOCK 70 KDA PROTEIN 1A-RELATED
P00059	p53 pathway	P04609	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	ISS	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IC	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DANRE|ZFIN=ZDB-GENE-040426-1354|UniProtKB=Q7T2C5	Protein kinase C	ISS	11880265	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95818|UniProtKB=Q61626	Glutamate receptor ionotropic, kainate 5	ISS	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00049	Parkinson disease	P01219	SAPK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	HUMAN|HGNC=9508|UniProtKB=P49768	Presenilin-1	IDA	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P05731	GABA-B receptor II signaling	P05755	Gbeta	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00047	PDGF signaling pathway	P01161	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00036	Interleukin signaling pathway	P00990	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04557	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00005	Angiogenesis	P00236	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00048	PI3 kinase pathway	P01199	Galpha	BOVIN|Ensembl=ENSBTAG00000013017|UniProtKB=P04696	Guanine nucleotide-binding protein G(t) subunit alpha-2	ISS			PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P00059	p53 pathway	P04633	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P02755	Methylmalonyl pathway	P03034	Methylmalonyl-CoA mutase	DEIRA|EnsemblGenome=DR_1189|UniProtKB=Q9RV41	Methylmalonyl-CoA mutase, alpha subunit, chain A	ISS			PTHR43589:SF3	SUBFAMILY NOT NAMED
P00060	Ubiquitin proteasome pathway	P01491	E2	MONDO|Ensembl=ENSMODG00000009451|UniProtKB=F7FZL4	Uncharacterized protein	ISS			PTHR43902:SF2	UBIQUITIN-CONJUGATING ENZYME E2 N
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	CANLF|Ensembl=ENSCAFG00000015662|UniProtKB=E2RHY4	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000000365|UniProtKB=F6R9F4	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04393	Ras Pathway	P04567	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IDA	1171954	gi	PTHR10048:SF14	PI-3 KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00057	Wnt signaling pathway	P01444	Wnt	PANTR|Ensembl=ENSPTRG00000012931|UniProtKB=H2QJF8	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P04393	Ras Pathway	P04559	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00056	VEGF signaling pathway	P01407	Erk	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01015	Glu4	HUMAN|HGNC=4574|UniProtKB=P48058	Glutamate receptor 4	ISS	10331083	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00384	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00056	VEGF signaling pathway	P01411	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00009	Axon guidance mediated by netrin	P00364	cdc42	CHICK|Ensembl=ENSGALG00000004796|UniProtKB=Q90694	Cell division control protein 42 homolog	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00010	B cell activation	P00398	IP3R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	SCLS1|EnsemblGenome=SS1G_03482|UniProtKB=A7EDU2	Guanine nucleotide-binding protein beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00034	Integrin signalling pathway	P00916	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ARATH|TAIR=AT5G23540|UniProtKB=Q9LT08	26S proteasome non-ATPase regulatory subunit 14 homolog	ISS	15237785	gi	PTHR10410:SF13	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 14 HOMOLOG
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00057	Wnt signaling pathway	P01435	SWI/SNF	ARATH|TAIR=AT3G06010|UniProtKB=F4J9M5	Probable ATP-dependent DNA helicase CHR12	ISS	11532957	PubMed	PTHR10799:SF873	ATP-DEPENDENT DNA HELICASE CHR12-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00941	Integrin alpha	HUMAN|HGNC=6137|UniProtKB=P17301	Integrin alpha-2	IPI	3487386	PubMed	PTHR23220:SF23	INTEGRIN ALPHA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	20331588	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	CANLF|Ensembl=ENSCAFG00000001097|UniProtKB=E2RCX6	Uncharacterized protein	ISS	8163524	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00206	Wnt	MOUSE|MGI=MGI=98962|UniProtKB=P28047	Protein Wnt-7b	ISS	8717036	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00012	Cadherin signaling pathway	P00477	GSK3beta	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	RCA	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	DANRE|ZFIN=ZDB-GENE-030131-9662|UniProtKB=Q6TEN1	Ras-related protein Rap-1b	ISS	8576107	PubMed	PTHR24070:SF382	RAS-RELATED PROTEIN RAP-1B
P04371	5-Hydroxytryptamine biosynthesis	P04399	Tryptophan hydroxylase	CHICK|Ensembl=ENSGALG00000010198|UniProtKB=F6RIS7	Uncharacterized protein	ISS	14597720	PubMed	PTHR11473:SF16	TRYPTOPHAN 5-HYDROXYLASE 2
P00025	Hedgehog signaling pathway	P00687	Cubitus interruptus repressor	MOUSE|MGI=MGI=95729|UniProtKB=Q61602	Transcriptional activator GLI3	IDA	10976059	PubMed	PTHR19818:SF5	TRANSCRIPTIONAL ACTIVATOR GLI3
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	IC	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1718748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04393	Ras Pathway	P04553	PAK	ORNAN|Ensembl=ENSOANG00000002406|UniProtKB=F7BAS2	Uncharacterized protein	ISS	7559398	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00056	VEGF signaling pathway	P01425	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00053	T cell activation	P01318	PKC-theta	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IGI	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00048	PI3 kinase pathway	P01185	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00010	B cell activation	P00383	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	IDA	9851932	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	BOVIN|Ensembl=ENSBTAG00000018114|UniProtKB=Q28043	Activin receptor type-2A	TAS	11252892	PubMed	PTHR23255:SF64	ACTIVIN RECEPTOR TYPE-2A
P00054	Toll receptor signaling pathway	P01368	MKK2	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00034	Integrin signalling pathway	P00941	Integrin alpha	CANLF|Ensembl=ENSCAFG00000004656|UniProtKB=F1PVR1	Uncharacterized protein	ISS	10778855	PubMed	PTHR23220:SF5	INTEGRIN ALPHA-8
P00057	Wnt signaling pathway	P01435	SWI/SNF	RAT|RGD=1305406|UniProtKB=D3ZBS9	Protein Smarcd1	ISS	11532957	PubMed	PTHR13844:SF1	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D MEMBER 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	HUMAN|HGNC=4404|UniProtKB=P59768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00056	VEGF signaling pathway	P01403	VEGFR-2	PANTR|Ensembl=ENSPTRG00000016069|UniProtKB=H2QPH6	Uncharacterized protein	ISS	11824379	PubMed	PTHR24416:SF45	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00060	Ubiquitin proteasome pathway	P01491	E2	HUMAN|HGNC=12495|UniProtKB=Q15819	Ubiquitin-conjugating enzyme E2 variant 2	ISS			PTHR43915:SF3	UBIQUITIN-CONJUGATING ENZYME E2 VARIANT 2
P00010	B cell activation	P00384	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00053	T cell activation	P01319	PAK	CHICK|Ensembl=ENSGALG00000000681|UniProtKB=E1C3P6	Uncharacterized protein	ISS	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00047	PDGF signaling pathway	P01142	p90RSK	MOUSE|MGI=MGI=1927343|UniProtKB=Q9Z1M4	Ribosomal protein S6 kinase beta-2	ISS	6755374	gi	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00055	Transcription regulation by bZIP transcription factor	P01390	TFIIA complex	CANLF|Ensembl=ENSCAFG00000016665|UniProtKB=E2R3G8	Transcription initiation factor IIA subunit 2	ISS			PTHR10966:SF0	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2
P05918	p38 MAPK pathway	P06023	MEF	MOUSE|MGI=MGI=99532|UniProtKB=Q60929	Myocyte-specific enhancer factor 2A	RCA	11274345	PubMed	PTHR11945:SF145	MYOCYTE-SPECIFIC ENHANCER FACTOR 2A
P00047	PDGF signaling pathway	P01162	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P06587	Nicotine pharmacodynamics pathway	P06614	TH	MOUSE|MGI=MGI=98735|UniProtKB=P24529	Tyrosine 3-monooxygenase	RCA	12480184	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00021	FGF signaling pathway	P00623	FGF	RAT|RGD=2606|UniProtKB=P70492	Fibroblast growth factor 10	ISS	12941620	PubMed	PTHR11486:SF21	FIBROBLAST GROWTH FACTOR 10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	PANTR|Ensembl=ENSPTRG00000007084|UniProtKB=H2Q9G5	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P05730	Endogenous cannabinoid signaling	P05746	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00021	FGF signaling pathway	P00642	MEK1-2	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000025373|UniProtKB=F6ZZG9	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IC	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00010	B cell activation	P00398	IP3R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	IGI	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P02749	Leucine biosynthesis	P03001	3-Isopropylmalate dehydrogenase	PHANO|EnsemblGenome=SNOG_02041|UniProtKB=F5HCK8	3-isopropylmalate dehydrogenase	ISS			PTHR42979:SF1	3-ISOPROPYLMALATE DEHYDROGENASE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	IDA	10995439	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00566	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00566	ERK	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	NAS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00644	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00034	Integrin signalling pathway	P00951	Jnk	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=101948|UniProtKB=P48615	Protein Wnt-11	TAS	8717036	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00053	T cell activation	P01307	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MACMU|Ensembl=ENSMMUG00000013187|UniProtKB=F6XQ37	Tubulin beta-1 chain	ISS	9454836	PubMed	PTHR11588:SF112	TUBULIN BETA-1 CHAIN
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04451	CRHR1	MACMU|Gene=CRHR1|UniProtKB=Q76LL8	Corticotropin-releasing factor receptor 1	ISS	11145609	PubMed	PTHR12011:SF175	CORTICOTROPIN-RELEASING FACTOR RECEPTOR 1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	PANTR|Ensembl=ENSPTRG00000006890|UniProtKB=H2Q943	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P02757	O-antigen biosynthesis	P03052	N-acetylglucosamine-1-phosphate uridyltransferase	AQUAE|EnsemblGenome=aq_607|UniProtKB=O66863	Bifunctional protein GlmU	ISS			PTHR43584:SF3	BIFUNCTIONAL PROTEIN GLMU
P00009	Axon guidance mediated by netrin	P00359	NFAT	MACMU|Ensembl=ENSMMUG00000021843|UniProtKB=F6RNI3	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00019	Endothelin signaling pathway	P00566	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	RAT|RGD=3425|UniProtKB=P97887	Presenilin-1	TAS	12736250	PubMed	PTHR10202:SF18	PRESENILIN-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05913	Enkephalin release	P05974	G-Protein (i)	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00010	B cell activation	P00398	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00029	Huntington disease	P00790	beta-Tubulin	PRIPA|Gene=PPA02893|UniProtKB=H3DZP2	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF120	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00975	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	14707121	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	IPI	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00010	B cell activation	P00402	Jnk	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00059	p53 pathway	P01486	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00821	Prolyl Hydroxylase	HUMAN|HGNC=14660|UniProtKB=Q96KS0	Egl nine homolog 2	IDA	12912907	PubMed	PTHR12907:SF6	EGL NINE HOMOLOG 2
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IGI	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00048	PI3 kinase pathway	P01200	SHIP	MOUSE|MGI=MGI=1333787|UniProtKB=Q6P549	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	TAS	10610720	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	RAT|RGD=1359546|UniProtKB=Q5XI42	Aldehyde dehydrogenase family 3 member B1	IC			PTHR43570:SF2	ALDEHYDE DEHYDROGENASE FAMILY 3 MEMBER B1
P00053	T cell activation	P01331	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	MONDO|Ensembl=ENSMODG00000014080|UniProtKB=F6R511	Uncharacterized protein (Fragment)	ISS	10806215	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00965	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00050	Plasminogen activating cascade	P01256	uPAR	HUMAN|HGNC=9053|UniProtKB=Q03405	Urokinase plasminogen activator surface receptor	IEA	11875697	gi	PTHR10624:SF6	UROKINASE PLASMINOGEN ACTIVATOR SURFACE RECEPTOR
P04398	p53 pathway feedback loops 2	P04658	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00053	T cell activation	P01322	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	PANTR|Ensembl=ENSPTRG00000000843|UniProtKB=H2QZN8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00845	Cyclooxygenase	MOUSE|MGI=MGI=97797|UniProtKB=P22437	Prostaglandin G/H synthase 1	TAS	10668482	PubMed	PTHR11903:SF6	PROSTAGLANDIN G/H SYNTHASE 1
P00029	Huntington disease	P00807	Actin	CAEBR|Gene=CBG23091|UniProtKB=A8Y4Q9	Protein CBR-ACT-2	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00059	p53 pathway	P01486	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06004	Mu or Delta receptor	RAT|RGD=3234|UniProtKB=P33535	Mu-type opioid receptor	RCA	11259487	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04657	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	RAT|RGD=2732|UniProtKB=P22756	Glutamate receptor ionotropic, kainate 1	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00562	p38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IGI	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00002	Alpha adrenergic receptor signaling pathway	P00078	Alpha1A/1B/1C	RAT|RGD=62064|UniProtKB=P23944	Alpha-1D adrenergic receptor	IC	11781138	PubMed	PTHR24248:SF14	ALPHA-1D ADRENERGIC RECEPTOR
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	MOUSE|MGI=MGI=96433|UniProtKB=Q60751	Insulin-like growth factor 1 receptor	ISS	2877871	PubMed	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00005	Angiogenesis	P00236	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00029	Huntington disease	P00780	Microtubule	HUMAN|HGNC=20773|UniProtKB=Q3ZCM7	Tubulin beta-8 chain	IDA	12932731	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	LEIMA|EnsemblGenome=LmjF.18.1080|UniProtKB=Q27687	Protein kinase A catalytic subunit	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00872	Rac	MACMU|Ensembl=ENSMMUG00000021075|UniProtKB=F7GY91	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00950	Paxillin	MOUSE|MGI=MGI=108295|UniProtKB=Q8VI36	Paxillin	IPI	7579684	PubMed	PTHR24216:SF11	PAXILLIN
P04393	Ras Pathway	P04542	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00557	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	TAS	87218499	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06587	Nicotine pharmacodynamics pathway	P06590	GNG	MOUSE|MGI=MGI=102705|UniProtKB=P63213	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P05730	Endogenous cannabinoid signaling	P05746	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00052	TGF-beta signaling pathway	P01288	FKBP12	BOVIN|Ensembl=ENSBTAG00000008303|UniProtKB=P18203	Peptidyl-prolyl cis-trans isomerase FKBP1A	ISS			PTHR10516:SF301	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED
P00048	PI3 kinase pathway	P01199	Galpha	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	BOVIN|Ensembl=ENSBTAG00000018445|UniProtKB=E1BK87	Uncharacterized protein	ISS	11554554	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00021	FGF signaling pathway	P00627	ERK1-2	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00539	14-3-3	PANTR|Ensembl=ENSPTRG00000014281|UniProtKB=H2QLJ0	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	ISS	10407019	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00029	Huntington disease	P00807	Actin	TRIVA|Gene=TVAG_512800|UniProtKB=A2HNG1	Actin (Fragment)	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00047	PDGF signaling pathway	P01145	c-fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00557	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P04611	P300	HUMAN|HGNC=3373|UniProtKB=Q09472	Histone acetyltransferase p300	ISS	10664585	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	IC	15313841	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	ARATH|TAIR=AT5G61210|UniProtKB=Q9S7P9	SNAP25 homologous protein SNAP33	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00931	Integrin beta	MONDO|Ensembl=ENSMODG00000007536|UniProtKB=K7E435	Integrin beta	ISS	3487386	PubMed	PTHR10082:SF28	INTEGRIN BETA-1
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00010	B cell activation	P00380	fos	RAT|RGD=2626|UniProtKB=P12841	Proto-oncogene c-Fos	TAS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	YEAST|SGD=S000005738|UniProtKB=P18851	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00006	Apoptosis signaling pathway	P00315	RIP	MACMU|Ensembl=ENSMMUG00000008485|UniProtKB=F6THC2	Uncharacterized protein	ISS	7538908	PubMed	PTHR44738:SF1	RECEPTOR-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	TAS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CHICK|Ensembl=ENSGALG00000008512|UniProtKB=F1P0S6	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	8838325	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00060	Ubiquitin proteasome pathway	P01491	E2	NEUCR|EnsemblGenome=EFNCRG00000003257|UniProtKB=Q7RVS7	Ubiquitin-conjugating enzyme E2	ISS			PTHR24068:SF74	FI16911P1-RELATED
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00007	Axon guidance mediated by semaphorins	P00341	Rho	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	ISS	10556059	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01159	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00004	Alzheimer disease-presenilin pathway	P00168	E-cadherin intracellular fragment	PANTR|Ensembl=ENSPTRG00000008269|UniProtKB=H2QBE4	Cadherin 3, type 1, P-cadherin (Placental)	ISS	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	PANTR|Ensembl=ENSPTRG00000020202|UniProtKB=H2QW34	Uncharacterized protein	ISS	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P06959	CCKR signaling map	G07001	IL8	HUMAN|HGNC=6025|UniProtKB=P10145	Interleukin-8	RCA	18395088	PubMed	PTHR10179:SF70	INTERLEUKIN-8
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	TAS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00647	SHP2	DANRE|ZFIN=ZDB-GENE-030131-5911|UniProtKB=F1QZU5	Tyrosine-protein phosphatase non-receptor type	ISS	14525967	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	SCHPO|PomBase=SPAC17G8.04c|UniProtKB=Q10316	Actin-related protein 2/3 complex subunit 5	ISS			PTHR12644:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01438	PP2A	MONDO|Ensembl=ENSMODG00000019001|UniProtKB=F7CP86	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00047	PDGF signaling pathway	P01160	IP3 receptor	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00006	Apoptosis signaling pathway	P00303	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	DROME|FlyBase=FBgn0024326|UniProtKB=O61444	MAP kinase kinase 4, isoform A	IC	7600581	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CHICK|Ensembl=ENSGALG00000011809|UniProtKB=F1NMB0	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00057	Wnt signaling pathway	P01443	Phospholipase C	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05915	Opioid proenkephalin pathway	P05988	peptide E	DANRE|ZFIN=ZDB-GENE-030729-3|UniProtKB=F1QTD1	Uncharacterized protein (Fragment)	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00057	Wnt signaling pathway	P01465	Ggamma	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000015240|UniProtKB=F6VUY3	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	PANTR|Ensembl=ENSPTRG00000011042|UniProtKB=H2QGF5	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00018	EGF receptor signaling pathway	P00542	EGFR	HUMAN|HGNC=3236|UniProtKB=P00533	Epidermal growth factor receptor	ISS	20540545	gi	PTHR24416:SF91	EPIDERMAL GROWTH FACTOR RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00057	Wnt signaling pathway	P01428	Frizzled	PANTR|Ensembl=ENSPTRG00000005632|UniProtKB=H2Q772	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF86	FRIZZLED-10
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05931	EGR	BOVIN|Gene=EGR1|UniProtKB=Q29W20	Early growth response protein 1	ISS			PTHR44685:SF1	EARLY GROWTH RESPONSE PROTEIN 1
P02757	O-antigen biosynthesis	P03052	N-acetylglucosamine-1-phosphate uridyltransferase	DEIRA|EnsemblGenome=DR_0808|UniProtKB=Q9RW61	Bifunctional protein GlmU	ISS			PTHR43584:SF3	BIFUNCTIONAL PROTEIN GLMU
P04398	p53 pathway feedback loops 2	P04665	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04557	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	RAT|RGD=3693|UniProtKB=Q01818	Chromaffin granule amine transporter	ISS	92370677	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04393	Ras Pathway	P04542	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	HUMAN|HGNC=1953|UniProtKB=P08173	Muscarinic acetylcholine receptor M4	TAS	12181435	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00005	Angiogenesis	P00205	GAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	88318957	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00046	Oxidative stress response	P01126	ATF2	CANLF|Ensembl=ENSCAFG00000013332|UniProtKB=F1PCQ4	Uncharacterized protein	ISS	10487205	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00016	Cytoskeletal regulation by Rho GTPase	P00521	Profilin	ORYSJ|EnsemblGenome=OS10G0323600|UniProtKB=Q9FUD1	Profilin-A	ISS			PTHR11604:SF0	PROFILIN
P04376	5HT4 type receptor mediated signaling pathway	P04426	K+ channel	BOVIN|Ensembl=ENSBTAG00000047488|UniProtKB=G3N1D1	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00053	T cell activation	P01322	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IGI	12464394	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	CANLF|Ensembl=ENSCAFG00000004381|UniProtKB=J9JH96	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DICDI|dictyBase=DDB_G0277143|UniProtKB=P36408	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00021	FGF signaling pathway	P00624	14-3-3	RAT|RGD=1359510|UniProtKB=Q5EBB0	Protein LOC298795	ISS	10407019	PubMed	PTHR18860:SF14	14-3-3 PROTEIN SIGMA
P00049	Parkinson disease	P01235	Fyn kinase	DANRE|ZFIN=ZDB-GENE-030903-5|UniProtKB=Q6EWH2	Tyrosine-protein kinase fyna	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00005	Angiogenesis	P00203	Erk	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04572	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_125401|UniProtKB=C3ZTX6	Putative uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05731	GABA-B receptor II signaling	P05753	Ca channel	MOUSE|MGI=MGI=1201678|UniProtKB=Q5SUF7	Protein Cacna1g	ISS	18021322	PubMed	PTHR10037:SF137	VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1G
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00047	PDGF signaling pathway	P01160	IP3 receptor	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00006	Apoptosis signaling pathway	P00280	PACT	MOUSE|MGI=MGI=1344375|UniProtKB=Q9WTX2	Interferon-inducible double-stranded RNA-dependent protein kinase activator A	ISS	10988289	PubMed	PTHR10910:SF8	INTERFERON-INDUCIBLE DOUBLE-STRANDED RNA-DEPENDENT PROTEIN KINASE ACTIVATOR A
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	MOUSE|MGI=MGI=106684|UniProtKB=Q8R090	Chromaffin granule amine transporter	ISS	92370677	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00004	Alzheimer disease-presenilin pathway	P00113	Erb-B4 transmembrane fragment	PANTR|Ensembl=ENSPTRG00000012883|UniProtKB=H2QJC5	Receptor protein-tyrosine kinase	ISS	4884676	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00005	Angiogenesis	P00235	c-Fos	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	IDA	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P02736	Coenzyme A biosynthesis	P02885	Pantothenate kinase	RAT|RGD=1305169|UniProtKB=F1LT70	Pantothenate kinase 2 (Hallervorden-Spatz syndrome) (Predicted), isoform CRA_a	ISS			PTHR12280:SF25	PANTOTHENATE KINASE 2, MITOCHONDRIAL
P00006	Apoptosis signaling pathway	P00310	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00019	Endothelin signaling pathway	P00567	PKG	MOUSE|MGI=MGI=108173|UniProtKB=Q61410	cGMP-dependent protein kinase 2	IGI	22181250	PubMed	PTHR24353:SF24	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00049	Parkinson disease	P01226	CDCrel-1	CANLF|Ensembl=ENSCAFG00000012960|UniProtKB=F1PEK5	Uncharacterized protein	ISS			PTHR18884:SF67	SEPTIN-2
P02734	Chorismate biosynthesis	P02868	Chorismate synthase	CHLTR|EnsemblGenome=CT_368|UniProtKB=O84373	Chorismate synthase	ISS			PTHR21085:SF0	CHORISMATE SYNTHASE
P00050	Plasminogen activating cascade	P01262	pro-uPA	CHICK|Gene=PLAU|UniProtKB=P15120	Urokinase-type plasminogen activator	ISS	137111	gi	PTHR44246:SF2	UROKINASE-TYPE PLASMINOGEN ACTIVATOR
P00018	EGF receptor signaling pathway	P00552	Ras	MACMU|Ensembl=ENSMMUG00000000664|UniProtKB=F7A890	Ras-related protein R-Ras2 isoform a	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00018	EGF receptor signaling pathway	P00556	PLCgamma	SCHPO|PomBase=SPAC22F8.11|UniProtKB=P40977	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1	IC			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	TAS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00034	Integrin signalling pathway	P00924	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	DANRE|ZFIN=ZDB-GENE-030131-6206|UniProtKB=F1Q5K4	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF676	MYOSIN, HEAVY POLYPEPTIDE 2, FAST MUSCLE SPECIFIC
P00029	Huntington disease	P00807	Actin	STRPU|Gene=CYIIIB|UniProtKB=P18499	Actin, cytoskeletal 3B	IDA	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P02777	Succinate to proprionate conversion	P03161	Methylmalonyl-CoA mutase	STRCO|Gene=CAB71846|UniProtKB=Q9L1X6	Probable isobutyryl-CoA mutase, small subunit	ISS			PTHR23408:SF19	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00235	c-Fos	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	IDA	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00054	Toll receptor signaling pathway	P01352	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04398	p53 pathway feedback loops 2	P04657	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05994	G-protein	ORNAN|Ensembl=ENSOANG00000003489|UniProtKB=F7FSE3	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	BOVIN|Ensembl=ENSBTAG00000009269|UniProtKB=F1MCM2	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00047	PDGF signaling pathway	P01153	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CAEEL|WormBase=WBGene00000064|UniProtKB=P10984	Actin-2	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BOVIN|Gene=ACTG2|UniProtKB=Q5E9B5	Actin, gamma-enteric smooth muscle	ISS	3487386	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00021	FGF signaling pathway	P00646	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00006	Apoptosis signaling pathway	P00284	Flip	MACMU|Ensembl=ENSMMUG00000012310|UniProtKB=F7DL95	CASP8 and FADD-like apoptosis regulator isoform 1	ISS	9217161	PubMed	PTHR10454:SF8	CASP8 AND FADD-LIKE APOPTOSIS REGULATOR
P00004	Alzheimer disease-presenilin pathway	P00114	actin	TRIAD|EnsemblGenome=TriadG56111|UniProtKB=B3RX77	Non-muscle actin 6.2	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	9860142	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00055	Transcription regulation by bZIP transcription factor	P01390	TFIIA complex	BOVIN|Ensembl=ENSBTAG00000013652|UniProtKB=F1MII0	Uncharacterized protein	ISS	600519	OMIM	PTHR12694:SF7	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1
P00057	Wnt signaling pathway	P01443	Phospholipase C	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00048	PI3 kinase pathway	P01192	p110	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00986	eNOS	RAT|RGD=3186|UniProtKB=Q62600	Nitric oxide synthase, endothelial	ISS	93055452	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P04398	p53 pathway feedback loops 2	P04668	p53	BOVIN|Ensembl=ENSBTAG00000005812|UniProtKB=G3X6J7	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000003364|UniProtKB=F6ZPQ4	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	BOVIN|Ensembl=ENSBTAG00000006194|UniProtKB=E1BNB5	Uncharacterized protein	ISS	10664585	PubMed	PTHR23351:SF6	FOS-RELATED ANTIGEN 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	SCHMA|EnsemblGenome=Smp_161920|UniProtKB=G4VSW5	Putative actin	IC	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02775	Salvage pyrimidine ribonucleotides	P03151	Uracil phosphoribosyl  transferase	AQUAE|EnsemblGenome=aq_2163|UniProtKB=O67914	Uracil phosphoribosyltransferase	ISS			PTHR10285:SF6	ATP-DEPENDENT KINASE TDA10-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00021	FGF signaling pathway	P00633	Ras	MONDO|Ensembl=ENSMODG00000025248|UniProtKB=F7F5X1	Uncharacterized protein	ISS	3023884	PubMed	PTHR24070:SF186	GTPASE KRAS
P00005	Angiogenesis	P00219	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00005	Angiogenesis	P00237	FRP	XENTR|Xenbase=XB-GENE-481353|UniProtKB=F6RNC2	Uncharacterized protein	ISS	9118218	PubMed	PTHR11309:SF96	FRIZZLED-RELATED PROTEIN
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00018	EGF receptor signaling pathway	P00564	Rac	DICPU|Gene=DICPUDRAFT_92985|UniProtKB=F1A084	Putative uncharacterized protein rac1A	ISS	4757952	gi	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2344|UniProtKB=P08485	Muscarinic acetylcholine receptor M4	IDA	11166329	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00029	Huntington disease	P00808	Caspase 8	MACMU|Ensembl=ENSMMUG00000031296|UniProtKB=F7C587	Uncharacterized protein	ISS	11917123	PubMed	PTHR10454:SF162	CASPASE-8
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	CANLF|Ensembl=ENSCAFG00000015081|UniProtKB=E2RMT4	Uncharacterized protein	ISS	9618202	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00005	Angiogenesis	P00243	Raf	MOUSE|MGI=MGI=88190|UniProtKB=P28028	Serine/threonine-protein kinase B-raf	ISS	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02747	Histidine biosynthesis	P02991	Histidinephosphate aminotransferase	DEIRA|EnsemblGenome=DR_2461|UniProtKB=Q9RRM7	Histidinol-phosphate aminotransferase	ISS			PTHR42790:SF3	KYNURENINE/ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00036	Interleukin signaling pathway	P00983	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MOUSE|MGI=MGI=87904|UniProtKB=P60710	Actin, cytoplasmic 1	IDA	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00021	FGF signaling pathway	P00645	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=263|UniProtKB=P29274	Adenosine receptor A2a	IDA			PTHR24246:SF27	ADENOSINE RECEPTOR A2A
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	MACMU|Ensembl=ENSMMUG00000014817|UniProtKB=F6VXD8	Uncharacterized protein	ISS	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00049	Parkinson disease	P01226	CDCrel-1	MOUSE|MGI=MGI=1270156|UniProtKB=P28661	Septin-4	IDA			PTHR18884:SF71	SEPTIN-4
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CHICK|Ensembl=ENSGALG00000002098|UniProtKB=F1P0L4	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	HUMAN|HGNC=4571|UniProtKB=P42261	Glutamate receptor 1	ISS	10331083	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MOUSE|MGI=MGI=88398|UniProtKB=Q9ERZ3	Muscarinic acetylcholine receptor M3	TAS	10069496	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CANLF|Ensembl=ENSCAFG00000005662|UniProtKB=E2R907	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	MOUSE|MGI=MGI=109284|UniProtKB=Q61144	Presenilin-2	IDA	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00892	Grb2	CAEBR|Gene=CBG16856|UniProtKB=A8XPY6	Protein CBR-SEM-5	ISS	17569445	gi	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00059	p53 pathway	P01486	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	RAT|RGD=1309935|UniProtKB=B0BN78	Protein Taf7	ISS			PTHR12228:SF6	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 7
P00010	B cell activation	P00398	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	IC	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00001	Adrenaline and noradrenaline biosynthesis	P00069	COMT	MOUSE|MGI=MGI=88470|UniProtKB=O88587	Catechol O-methyltransferase	ISS	12842307	PubMed	PTHR43836:SF3	CATECHOL O-METHYLTRANSFERASE
P05915	Opioid proenkephalin pathway	P05992	met-Enkephalin	DANRE|ZFIN=ZDB-GENE-030729-3|UniProtKB=F1QTD1	Uncharacterized protein (Fragment)	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=12786|UniProtKB=O00755	Protein Wnt-7a	IDA	11266476	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00010	B cell activation	P00367	NFAT	RAT|RGD=1308692|UniProtKB=A0A0G2JTY4	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 (Predicted), isoform CRA_b	ISS	12787506	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	NAS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00053	T cell activation	P01306	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00022	General transcription by RNA polymerase I	P00652	RNA Polymerase I  Complex	BOVIN|Ensembl=ENSBTAG00000014166|UniProtKB=A6QLS0	DNA-directed RNA polymerase subunit beta	ISS	15691654	PubMed	PTHR20856:SF5	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00036	Interleukin signaling pathway	P00965	ERK	HUMAN|HGNC=24667|UniProtKB=Q8TD08	Mitogen-activated protein kinase 15	IC	10514528	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=621025|UniProtKB=Q62711	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	15611108	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P02775	Salvage pyrimidine ribonucleotides	P03150	Uridine kinase	BOVIN|Ensembl=ENSBTAG00000044150|UniProtKB=E1BMA5	Uridine kinase	ISS			PTHR10285:SF70	URIDINE-CYTIDINE KINASE 2
P00049	Parkinson disease	P01213	Cyclin E	MOUSE|MGI=MGI=88316|UniProtKB=Q61457	G1/S-specific cyclin-E1	ISS	15705141	gi	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00053	T cell activation	P01322	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	XENTR|Xenbase=XB-GENE-481916|UniProtKB=F6YF14	Presenilin	ISS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00036	Interleukin signaling pathway	P00977	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P04393	Ras Pathway	P04557	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00056	VEGF signaling pathway	P01413	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	MONDO|Ensembl=ENSMODG00000025188|UniProtKB=F7C1G3	Uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00010	B cell activation	P00398	IP3R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	IGI	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	TAKRU|Ensembl=ENSTRUG00000014690|UniProtKB=H2UKR9	Uncharacterized protein	ISS	2039532	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	12855688	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00047	PDGF signaling pathway	P01142	p90RSK	MONDO|Ensembl=ENSMODG00000006241|UniProtKB=F7FRY0	Ribosomal protein S6 kinase	ISS	15526037	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00589	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00785	Cytochrome c	PANTR|Ensembl=ENSPTRG00000020679|UniProtKB=H2QWV8	Cytochrome c-1	ISS	9027315	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000003128|UniProtKB=H2Q2V4	Uncharacterized protein	ISS	12181435	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	DICDI|dictyBase=DDB_G0283265|UniProtKB=Q54R82	Mitogen-activated protein kinase kinase kinase A	IGI	99051319	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01095	beta	PANTR|Ensembl=ENSPTRG00000001389|UniProtKB=H2Q056	Uncharacterized protein	ISS	22213672	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P00049	Parkinson disease	P01238	14-3-3	ORYSJ|EnsemblGenome=OS08G0480800|UniProtKB=Q84J55	14-3-3-like protein GF14-A	ISS	10918058	PubMed	PTHR18860:SF26	14-3-3 FAMILY PROTEIN-RELATED
P00035	Interferon-gamma signaling pathway	P00961	STAT1	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	12191995	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00054	Toll receptor signaling pathway	P01375	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MOUSE|MGI=MGI=98728|UniProtKB=Q64729	TGF-beta receptor type-1	TAS	10683140	PubMed	PTHR23255:SF61	TGF-BETA RECEPTOR TYPE-1
P00057	Wnt signaling pathway	P01451	Galpha	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	ORNAN|Ensembl=ENSOANG00000007732|UniProtKB=F6PXH5	Uncharacterized protein (Fragment)	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00094	BACE-1 pro-domain	HUMAN|HGNC=933|UniProtKB=P56817	Beta-secretase 1	IDA	10531052	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00005	Angiogenesis	P00223	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00977	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P06959	CCKR signaling map	P07036	G34-Gly	HUMAN|HGNC=4164|UniProtKB=P01350	Gastrin	RCA		PubMed	PTHR19309:SF0	GASTRIN
P05916	Opioid prodynorphin pathway	P06002	G-protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04397	p53 pathway by glucose deprivation	P04641	Akt	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02756	N-acetylglucosamine metabolism	P03041	Glucosamine-6-phosphate deaminase	BACSU|EnsemblGenome=BSU35020|UniProtKB=O35000	Glucosamine-6-phosphate deaminase 1	ISS			PTHR11280:SF5	GLUCOSAMINE-6-PHOSPHATE ISOMERASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014262|UniProtKB=F7BYS8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04398	p53 pathway feedback loops 2	P04658	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00017	DNA replication	P00531	Pol alpha	XENTR|Xenbase=XB-GENE-1000548|UniProtKB=F6Z608	DNA polymerase	ISS	11493738	gi	PTHR10322:SF21	DNA POLYMERASE ALPHA CATALYTIC SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00052	TGF-beta signaling pathway	P01284	JNK	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	TAS	12040174	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00544	c-Cbl	PANTR|Ensembl=ENSPTRG00000004378|UniProtKB=H2Q4Y2	Cas-Br-M (Murine) ecotropic retroviral transforming sequence	ISS	4885117	gi	PTHR23007:SF5	E3 UBIQUITIN-PROTEIN LIGASE CBL
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	10693759	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P06959	CCKR signaling map	P07211	HuR	HUMAN|HGNC=3312|UniProtKB=Q15717	ELAV-like protein 1	RCA	18395088	PubMed	PTHR43938:SF4	ELAV-LIKE PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	CHICK|Ensembl=ENSGALG00000005518|UniProtKB=F1NTL1	Protein-serine/threonine kinase	RCA			PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	DROME|FlyBase=FBgn0010399|UniProtKB=Q24418	Glutamate [NMDA] receptor subunit 1	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00034	Integrin signalling pathway	P00907	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9062|UniProtKB=Q9BRC7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	7822322	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00029	Huntington disease	G01530	HTT	RAT|RGD=68337|UniProtKB=P51111	Huntingtin	IDA	8268927	PubMed	PTHR10170:SF10	HUNTINGTIN
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	PANTR|Ensembl=ENSPTRG00000018684|UniProtKB=C7G3M7	Glutamate receptor, metabotropic 1	ISS	14614461	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00057	Wnt signaling pathway	P01465	Ggamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00056	VEGF signaling pathway	P01425	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	15572354	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00060	Ubiquitin proteasome pathway	P01491	E2	CAEEL|WormBase=WBGene00006704|UniProtKB=P34477	Probable ubiquitin-conjugating enzyme E2 7	ISS			PTHR24067:SF3	UBIQUITIN-CONJUGATING ENZYME E2 G1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01076	CAT	BOVIN|Ensembl=ENSBTAG00000016814|UniProtKB=F1MLQ5	Uncharacterized protein	ISS	92155737	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	RAT|RGD=2735|UniProtKB=Q63273	Glutamate receptor ionotropic, kainate 5	ISS	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	NAS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	P01458	Protein Kinase C	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00059	p53 pathway	P04623	CBP	ARATH|TAIR=AT1G67220|UniProtKB=Q9FYH1	Histone acetyltransferase HAC2	IDA	10769018	PubMed	PTHR13808:SF6	HISTONE ACETYLTRANSFERASE HAC2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	IC	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	IC	15860573	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P04395	Vasopressin synthesis	P04589	Signal Peptidase	MACMU|Ensembl=ENSMMUG00000022784|UniProtKB=F7G8J6	Uncharacterized protein	ISS	1546959	PubMed	PTHR12804:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 3
P00005	Angiogenesis	P00238	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	TAS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=621025|UniProtKB=Q62711	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	7822322	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	MACMU|Ensembl=ENSMMUG00000010173|UniProtKB=F7AGU8	Presenilin	ISS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	HUMAN|HGNC=3087|UniProtKB=Q92997	Segment polarity protein dishevelled homolog DVL-3	TAS	10409711	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P00006	Apoptosis signaling pathway	P00269	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00566	ERK	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	IGI	9836510	gi	PTHR24055:SF330	SUBFAMILY NOT NAMED
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	RAT|RGD=628852|UniProtKB=Q02294	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	14624853	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P05913	Enkephalin release	P05974	G-Protein (i)	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00189	Fzd	DANRE|ZFIN=ZDB-GENE-000328-4|UniProtKB=B0S6S2	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF90	FRIZZLED-8
P00047	PDGF signaling pathway	P01150	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IGI	7565716	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P02738	De novo purine biosynthesis	P02902	ADP reductase	BACSU|EnsemblGenome=BSU17390|UniProtKB=P50621	Ribonucleoside-diphosphate reductase subunit beta	ISS			PTHR23409:SF32	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT BETA
P00047	PDGF signaling pathway	P01161	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00780	Microtubule	CHICK|GeneID=431043|UniProtKB=P09652	Tubulin beta-4 chain	IDA	12932731	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	HUMAN|HGNC=1401|UniProtKB=Q02641	Voltage-dependent L-type calcium channel subunit beta-1	ISS	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P02750	Lipoate_biosynthesis	P03003	Lipoyl-protein ligase	MYCTU|EnsemblGenome=Rv2217|UniProtKB=P9WK83	Octanoyltransferase	ISS			PTHR10993:SF2	OCTANOYLTRANSFERASE
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	MOUSE|MGI=MGI=109482|UniProtKB=P97445	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	14507926	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P02756	N-acetylglucosamine metabolism	P03040	N-acetylneuraminate lyase	PANTR|Ensembl=ENSPTRG00000001758|UniProtKB=H2Q0Q9	N-acetylneuraminate pyruvate lyase (Dihydrodipicolinate synthase)	ISS			PTHR12128:SF21	N-ACETYLNEURAMINATE LYASE
P05730	Endogenous cannabinoid signaling	P05751	Galpha	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02743	Formyltetrahydroformate biosynthesis	P02956	Formyl tetrahydrofolate deformylase	DEIRA|EnsemblGenome=DR_0584|UniProtKB=Q9RWT1	Formyltetrahydrofolate deformylase	ISS			PTHR42706:SF1	FORMYLTETRAHYDROFOLATE DEFORMYLASE 1, MITOCHONDRIAL-RELATED
P04393	Ras Pathway	P04543	MEKK1/4	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00053	T cell activation	P01320	PLC-gamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04393	Ras Pathway	P04557	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00048	PI3 kinase pathway	P01179	PKB	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	MOUSE|MGI=MGI=102891|UniProtKB=P51829	Adenylate cyclase type 7	IC	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00054	Toll receptor signaling pathway	P01375	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	PANTR|Ensembl=ENSPTRG00000018607|UniProtKB=H2QTR3	Syntaxin 7	ISS	14570579	PubMed	PTHR19957:SF90	SYNTAXIN-7
P00047	PDGF signaling pathway	P01171	PLCgamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00053	T cell activation	P01305	Calmodulin	CIOIN|Ensembl=ENSCING00000008616|UniProtKB=F6T2A6	Uncharacterized protein	ISS			PTHR23050:SF245	AT16150P-RELATED
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	ARATH|TAIR=AT1G25350|UniProtKB=Q8W4F3	Glutamine--tRNA ligase, cytoplasmic	ISS			PTHR43097:SF4	GLUTAMINE--TRNA LIGASE-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000002658|UniProtKB=F7CB14	Uncharacterized protein	ISS	12181435	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00018	EGF receptor signaling pathway	P00551	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IGI	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	G04694	p110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	RAT|RGD=3852|UniProtKB=P80204	TGF-beta receptor type-1	IDA			PTHR23255:SF61	TGF-BETA RECEPTOR TYPE-1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=19218|UniProtKB=Q86YW0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1	TAS			PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01142	p90RSK	CHICK|Ensembl=ENSGALG00000016406|UniProtKB=F1NLJ3	Uncharacterized protein	ISS	6755374	gi	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00021	FGF signaling pathway	P00642	MEK1-2	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9062|UniProtKB=Q9BRC7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	15611108	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00004	Alzheimer disease-presenilin pathway	P00114	actin	GIAIC|EnsemblGenome=GL50803_40817|UniProtKB=A8BV70	Actin related protein	IDA			PTHR11937:SF155	ACTIN-5C-RELATED
P00054	Toll receptor signaling pathway	P01360	IKKbeta	MOUSE|MGI=MGI=1338071|UniProtKB=O88351	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	XENTR|Xenbase=XB-GENE-483904|UniProtKB=F7ESG8	Receptor protein serine/threonine kinase (Fragment)	ISS	9395284	PubMed	PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00006	Apoptosis signaling pathway	P00310	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IDA	1171954	gi	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P05918	p38 MAPK pathway	P06026	MEKK4	CANLF|Ensembl=ENSCAFG00000000760|UniProtKB=E2R9L4	Uncharacterized protein	ISS	9305639	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Ensembl=ENSGALG00000028102|UniProtKB=F1P3X4	Uncharacterized protein	IEP	89264452	PubMed	PTHR13140:SF657	MYOSIN-4
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00021	FGF signaling pathway	P00644	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05941	GRK3	MONDO|Ensembl=ENSMODG00000010516|UniProtKB=F7DR73	Protein-serine/threonine kinase	ISS	10852916	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	HUMAN|HGNC=143|UniProtKB=P68032	Actin, alpha cardiac muscle 1	IDA	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00038	JAK/STAT signaling pathway	P01027	STAT	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	ISS	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00036	Interleukin signaling pathway	P00973	PKB	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00009	Axon guidance mediated by netrin	P00366	Rac	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Ensembl=ENSCAFG00000006805|UniProtKB=F1Q1Q4	Uncharacterized protein	ISS	6323229	PubMed	PTHR24248:SF26	ALPHA-2B ADRENERGIC RECEPTOR
P04385	Histamine H1 receptor mediated signaling pathway	P04485	H1	MACMU|Ensembl=ENSMMUG00000004817|UniProtKB=F6QJP0	Histamine H1 receptor	ISS	2670975	PubMed	PTHR43914:SF2	HISTAMINE H1 RECEPTOR
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IPI	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01408	Akt/PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00632	Akt	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	IGI	12719720	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	TAKRU|Ensembl=ENSTRUG00000004787|UniProtKB=P53480	Actin, alpha cardiac	IDA	14684598	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	CANLF|Ensembl=ENSCAFG00000000433|UniProtKB=F1PGJ3	Uncharacterized protein	ISS			PTHR10937:SF10	GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE  ISOMERIZING  2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	BOVIN|Ensembl=ENSBTAG00000000219|UniProtKB=F1MCL3	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00047	PDGF signaling pathway	P01162	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04570	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	IDA	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00648	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IGI	15572354	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00005	Angiogenesis	P00218	STAT1	DANRE|ZFIN=ZDB-GENE-980526-499|UniProtKB=Q6P943	Signal transducer and activator of transcription	ISS	99348060	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00047	PDGF signaling pathway	P01140	ELK	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	11050086	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00059	p53 pathway	G04694	p110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	DICDI|dictyBase=DDB_G0279407|UniProtKB=P02599	Calmodulin	ISS			PTHR23050:SF245	AT16150P-RELATED
P00047	PDGF signaling pathway	P01160	IP3 receptor	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04546	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	IDA	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00057	Wnt signaling pathway	P01465	Ggamma	RAT|RGD=621516|UniProtKB=G3V6P8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00049	Parkinson disease	P01235	Fyn kinase	CANLF|Ensembl=ENSCAFG00000003995|UniProtKB=E2RC09	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00019	Endothelin signaling pathway	P00576	Pre-pro ET1-4	RAT|RGD=2533|UniProtKB=P23943	Endothelin-2	ISS	8201007	PubMed	PTHR13874:SF9	ENDOTHELIN-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	ANOGA|EnsemblGenome=AGAP005911|UniProtKB=Q7Q6D4	AGAP005911-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00005	Angiogenesis	P00244	MAPKAPK2/3	PANTR|Ensembl=ENSPTRG00000001915|UniProtKB=H2Q104	Mitogen-activated protein kinase-activated protein kinase 2	ISS	8262198	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00035	Interferon-gamma signaling pathway	P00958	PIAS	RAT|RGD=708413|UniProtKB=O70260	E3 SUMO-protein ligase PIAS3	TAS	8682149	PubMed	PTHR10782:SF10	E3 SUMO-PROTEIN LIGASE PIAS3
P02736	Coenzyme A biosynthesis	P02885	Pantothenate kinase	MOUSE|MGI=MGI=1922985|UniProtKB=Q8K4K6	Pantothenate kinase 1	ISS			PTHR12280:SF23	PANTOTHENATE KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00046	Oxidative stress response	P01132	c-jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	FUSNN|EnsemblGenome=FN1231|UniProtKB=Q8RE86	Inosine-5'-monophosphate dehydrogenase	ISS			PTHR11911:SF6	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00203	Erk	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00648	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IGI	10747026	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00053	T cell activation	P01294	NFAT	HUMAN|HGNC=7777|UniProtKB=Q12968	Nuclear factor of activated T-cells, cytoplasmic 3	IGI	9462517	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00046	Oxidative stress response	P01129	JNK1/2	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=13251|UniProtKB=Q9UJ99	Cadherin-22	IDA	8120095	PubMed	PTHR24027:SF311	CADHERIN-22
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00060	Ubiquitin proteasome pathway	P01491	E2	PANTR|Ensembl=ENSPTRG00000017303|UniProtKB=H2QRL6	Ubiquitin-conjugating enzyme E2D 2	ISS			PTHR24068:SF40	UBIQUITIN-CONJUGATING ENZYME E2 D2-RELATED
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00018	EGF receptor signaling pathway	P00543	ERK1-2	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	IGI	11707292	PubMed	PTHR24055:SF330	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=106672|UniProtKB=P33146	Cadherin-15	IDA	8120095	PubMed	PTHR24027:SF300	CADHERIN-15
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	RAT|RGD=1359694|UniProtKB=P62836	Ras-related protein Rap-1A	ISS	8576107	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95808|UniProtKB=P23818	Glutamate receptor 1	ISS	10331083	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00049	Parkinson disease	P01219	SAPK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00024	Glycolysis	P00676	Glyceraldehyde 3-phosphate dehydrogenase	ECOLI|EcoGene=EG10367|UniProtKB=P0A9B2	Glyceraldehyde-3-phosphate dehydrogenase A	RCA			PTHR10836:SF76	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE A
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	CAEBR|Gene=CBG02850|UniProtKB=A8WTD8	Protein CBG02850	ISS			PTHR10937:SF0	GH12731P-RELATED
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=3023|UniProtKB=P14416	D(2) dopamine receptor	IDA	2137198	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00005	Angiogenesis	P00226	Delta/Serrate	BOVIN|Ensembl=ENSBTAG00000012817|UniProtKB=E1BDN7	Delta-like protein	ISS	10551863	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P04395	Vasopressin synthesis	P04597	Signal Peptide	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00006	Apoptosis signaling pathway	P00269	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	ISS	15860573	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P05730	Endogenous cannabinoid signaling	P05746	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04393	Ras Pathway	P04567	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	IDA	14526383	PubMed	PTHR10048:SF14	PI-3 KINASE
P00057	Wnt signaling pathway	P01456	beta-arrestin	MACMU|Ensembl=ENSMMUG00000017654|UniProtKB=F6UI32	Beta-arrestin-2 isoform 1	ISS	4757780	gi	PTHR11792:SF20	BETA-ARRESTIN-2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00016	Cytoskeletal regulation by Rho GTPase	P00521	Profilin	BOVIN|Ensembl=ENSBTAG00000020353|UniProtKB=Q32PB1	Profilin-3	ISS			PTHR13936:SF2	PROFILIN-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	PANTR|Ensembl=ENSPTRG00000001791|UniProtKB=H2R8B2	Uncharacterized protein	ISS	12193720	PubMed	PTHR10845:SF32	REGULATOR OF G-PROTEIN SIGNALING 13
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	88241036	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04393	Ras Pathway	P04558	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	RAT|RGD=69319|UniProtKB=P54313	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00049	Parkinson disease	P01240	hSel10	PANTR|Ensembl=ENSPTRG00000016514|UniProtKB=H2QQA2	F-box and WD repeat domain containing 7	RCA			PTHR44007:SF6	F-BOX/WD REPEAT-CONTAINING PROTEIN 7
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00916	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00030	Hypoxia response via HIF activation	P00819	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	IC	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00047	PDGF signaling pathway	P01167	Ets	BOVIN|Ensembl=ENSBTAG00000021993|UniProtKB=A2VDR4	SAM pointed domain containing ets transcription factor	ISS	15298723	PubMed	PTHR11849:SF182	SAM POINTED DOMAIN-CONTAINING ETS TRANSCRIPTION FACTOR
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	IDA	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02744	Fructose galactose metabolism	P02966	Hexokinase	MOUSE|MGI=MGI=2384910|UniProtKB=Q91W97	Putative hexokinase HKDC1	RCA			PTHR19443:SF28	HEXOKINASE HKDC1-RELATED
P00059	p53 pathway	P04615	MTA2	RAT|RGD=1306743|UniProtKB=B2GV01	Metastasis-associated gene family, member 2	ISS	11099047	PubMed	PTHR10865:SF4	METASTASIS-ASSOCIATED PROTEIN MTA2
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	STRCO|Gene=CAB82051|UniProtKB=Q9L0F9	Glutamate dehydrogenase	ISS			PTHR43571:SF1	NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED
P00036	Interleukin signaling pathway	P00977	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	TRYB2|Gene=Tb11.02.5720|UniProtKB=Q384N4	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00203	Erk	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00568	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04413	K+ channel	MACMU|Ensembl=ENSMMUG00000005826|UniProtKB=F6VE51	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00018	EGF receptor signaling pathway	P00550	Grb2	RAT|RGD=1306884|UniProtKB=Q4KM68	GRB2-related adaptor protein	ISS	11971956	PubMed	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P00034	Integrin signalling pathway	P00948	Rho	CAEBR|Gene=CBG13664|UniProtKB=A8XIF5	Protein CBR-RHO-1	ISS	11973360	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IDA	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT1G10210|UniProtKB=Q39021	Mitogen-activated protein kinase 1	IDA	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00053	T cell activation	P01322	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00019	Endothelin signaling pathway	P00584	Gs	MACMU|Ensembl=ENSMMUG00000010266|UniProtKB=F6PV18	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00019	Endothelin signaling pathway	P00586	Gq	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01026	KA	CHICK|Ensembl=ENSGALG00000015835|UniProtKB=F1NZT2	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P02757	O-antigen biosynthesis	P03045	dTDP-glucose 4,6-dehydratase	GLOVI|Gene=BAC88409|UniProtKB=Q7NNE3	dTDP-glucose 4,6-dehydratase	ISS			PTHR43000:SF7	DTDP-D-GLUCOSE 4,6-DEHYDRATASE
P04392	P53 pathway feedback loops 1	P04537	p73DeltaN	CANLF|Ensembl=ENSCAFG00000013961|UniProtKB=F1PL57	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P04398	p53 pathway feedback loops 2	G04714	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00047	PDGF signaling pathway	P01165	SRF	MONDO|Ensembl=ENSMODG00000018981|UniProtKB=F7FP88	Uncharacterized protein	ISS	15170389	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00034	Integrin signalling pathway	P00922	Collagen	HUMAN|HGNC=2211|UniProtKB=P12109	Collagen alpha-1(VI) chain	IDA	10727440	PubMed	PTHR44172:SF3	COLLAGEN ALPHA-1 VI  CHAIN
P00019	Endothelin signaling pathway	P00568	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	HUMAN|HGNC=6697|UniProtKB=O75197	Low-density lipoprotein receptor-related protein 5	IDA	11907044	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00021	FGF signaling pathway	P00640	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	SCHPO|PomBase=SPAC17G8.14c|UniProtKB=P36582	Protein kinase C-like 1	IGI	93259141	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04395	Vasopressin synthesis	P04589	Signal Peptidase	HUMAN|HGNC=28962|UniProtKB=Q15005	Signal peptidase complex subunit 2	ISS	2092035	PubMed	PTHR13085:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 2
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00029	Huntington disease	P00788	Calpain	MOUSE|MGI=MGI=1891369|UniProtKB=Q9ER56	Calpain-12	IDA	11675509	PubMed	PTHR10183:SF280	CALPAIN-12
P00054	Toll receptor signaling pathway	P01358	ERK1	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	12885769	PubMed	PTHR10202:SF13	PRESENILIN-2
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	ARATH|TAIR=AT5G50370|UniProtKB=Q9FK35	Adenylate kinase 3	ISS			PTHR23359:SF22	GTP:AMP PHOSPHOTRANSFERASE, MITOCHONDRIAL
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	88241036	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00005	Angiogenesis	P00221	JNK1	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000002297|UniProtKB=F1N167	Uncharacterized protein	ISS			PTHR11824:SF7	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DROME|FlyBase=FBgn0004623|UniProtKB=P29829	Guanine nucleotide-binding protein subunit beta-2	IC			PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00034	Integrin signalling pathway	P00914	Filamin	BOVIN|Ensembl=ENSBTAG00000011190|UniProtKB=F1N169	Uncharacterized protein	ISS	11911837	PubMed	PTHR43998:SF6	FILAMIN-A
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05938	RhoA	MONDO|Ensembl=ENSMODG00000012981|UniProtKB=F7CS91	Uncharacterized protein	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	RAT|RGD=2736|UniProtKB=P35439	Glutamate receptor ionotropic, NMDA 1	IC	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04398	p53 pathway feedback loops 2	P04651	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02721	ATP synthesis	P02796	F1 gamma	ORNAN|Ensembl=ENSOANG00000015444|UniProtKB=F6TI82	ATP synthase subunit gamma	ISS	2526651	PubMed	PTHR11693:SF22	ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00045	Notch signaling pathway	P01113	Pen-2	HUMAN|HGNC=9509|UniProtKB=P49810	Presenilin-2	IPI	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00052	TGF-beta signaling pathway	P01275	P38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	TAS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00036	Interleukin signaling pathway	P00983	Raf	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00057	Wnt signaling pathway	P01448	CBP	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	HUMAN|HGNC=4580|UniProtKB=Q13002	Glutamate receptor ionotropic, kainate 2	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P05730	Endogenous cannabinoid signaling	P05746	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00008	Axon guidance mediated by Slit/Robo	P00355	Rho	CAEEL|WormBase=WBGene00004357|UniProtKB=Q22038	Ras-like GTP-binding protein rhoA	ISS	11973360	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00021	FGF signaling pathway	P00644	p38	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	8925912	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00018	EGF receptor signaling pathway	P00562	p38	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	8925912	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00010	B cell activation	P00371	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00807	Actin	PHYPA|Gene=PHYPADRAFT_198730|UniProtKB=Q6TYS2	Actin 1	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	MOUSE|MGI=MGI=95821|UniProtKB=Q01097	Glutamate receptor ionotropic, NMDA 2B	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	PANTR|Gene=CHRM3|UniProtKB=Q9N2A4	Muscarinic acetylcholine receptor M3	ISS	10069496	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=2667185|UniProtKB=Q9JMH9	Unconventional myosin-XVIIIa	IC			PTHR13140:SF421	UNCONVENTIONAL MYOSIN-XVIIIA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00006	Apoptosis signaling pathway	P00292	IkappaB	CANLF|Ensembl=ENSCAFG00000013418|UniProtKB=E2RML9	Uncharacterized protein	ISS	14665694	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CAEEL|WormBase=WBGene00000055|UniProtKB=P48180	Acetylcholine receptor subunit alpha-type acr-16	IC	85270494	PubMed	PTHR18945:SF578	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-TYPE ACR-16
P05915	Opioid proenkephalin pathway	P05994	G-protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00010	B cell activation	P00371	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00049	Parkinson disease	P01211	ERK	CAEEL|WormBase=WBGene00015478|UniProtKB=Q11179	Putative serine/threonine-protein kinase C05D10.2	IDA	10514528	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00005	Angiogenesis	P00211	GSK3beta	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IDA	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00021	FGF signaling pathway	P00645	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	4757952	gi	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00018	EGF receptor signaling pathway	G01511	SPRY	PANTR|Ensembl=ENSPTRG00000005951|UniProtKB=H2Q7P2	Sprouty homolog 2	ISS	12402043	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P00012	Cadherin signaling pathway	P00470	F-actin	PHYPA|Gene=PHYPADRAFT_225906|UniProtKB=A9TVP1	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	P01457	GBeta	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CAEEL|WormBase=WBGene00004036|UniProtKB=G5EFI8	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00045	Notch signaling pathway	P01112	CoR	ANOGA|EnsemblGenome=AGAP004952|UniProtKB=Q7Q7Y6	AGAP004952-PA	TAS	11112321	PubMed	PTHR13151:SF2	COREPRESSOR INTERACTING WITH RBPJ 1
P02747	Histidine biosynthesis	P02988	Histidinal dehydrogenase	THEMA|EnsemblGenome=TM_1041|UniProtKB=Q9X0D1	Histidinol dehydrogenase	ISS			PTHR21256:SF2	HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN
P00059	p53 pathway	P01481	ATM/ATR	BOVIN|Ensembl=ENSBTAG00000011529|UniProtKB=F1MLY7	Uncharacterized protein	ISS	10196661	PubMed	PTHR11139:SF69	SERINE/THREONINE-PROTEIN KINASE ATR
P04393	Ras Pathway	P04557	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IDA	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00625	MKK3,6	BOVIN|Ensembl=ENSBTAG00000010576|UniProtKB=A4IFH7	MAP2K3 protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	RAT|RGD=2740|UniProtKB=Q62645	Glutamate receptor ionotropic, NMDA 2D	IC	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00539	14-3-3	HUMAN|HGNC=12855|UniProtKB=P63104	14-3-3 protein zeta/delta	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00022	General transcription by RNA polymerase I	P00652	RNA Polymerase I  Complex	SCHPO|PomBase=SPAC1687.01|UniProtKB=Q09177	DNA-directed RNA polymerases I and III subunit RPAC2	ISS			PTHR13946:SF28	DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00638	PLCgamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00029	Huntington disease	P00786	ARF	YEAST|SGD=S000002296|UniProtKB=P19146	ADP-ribosylation factor 2	IPI	12932731	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	DROME|FlyBase=FBgn0001991|UniProtKB=Q24270	Voltage-dependent calcium channel type D subunit alpha-1	IC	8838325	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01177	P110ACT	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	RAT|RGD=69319|UniProtKB=P54313	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02728	Arginine biosynthesis	P02848	N-acetylglutamate synthase	SCHPO|PomBase=SPAC4G9.09c|UniProtKB=P31318	Protein arg11, mitochondrial	ISS			PTHR23342:SF0	N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	RAT|RGD=620250|UniProtKB=Q63639	Retinal dehydrogenase 2	IC	14724059	PubMed	PTHR11699:SF102	RETINAL DEHYDROGENASE 2
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	MACMU|Ensembl=ENSMMUG00000017022|UniProtKB=F7HQZ9	Uncharacterized protein	ISS	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00015	Circadian clock system	G01501	cry	MACMU|Ensembl=ENSMMUG00000021808|UniProtKB=F7ENG9	Cryptochrome-1	ISS	10428031	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00023	General transcription regulation	P00668	TFIIB	ARATH|TAIR=AT2G41630|UniProtKB=P48512	Transcription initiation factor IIB-1	ISS			PTHR11618:SF37	CYCLIN FAMILY PROTEIN-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	RAT|RGD=619731|UniProtKB=Q9QYP1	Low-density lipoprotein receptor-related protein 4	ISS	11907044	PubMed	PTHR44017:SF4	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4
P00057	Wnt signaling pathway	P01447	Dishevelled	MACMU|Ensembl=ENSMMUG00000006553|UniProtKB=F7HRY3	Uncharacterized protein	ISS	11212302	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P00010	B cell activation	P00402	Jnk	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00015	Circadian clock system	G01499	per	MOUSE|MGI=MGI=1098283|UniProtKB=O35973	Period circadian protein homolog 1	IDA	12782655	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P04398	p53 pathway feedback loops 2	P04665	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01162	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000017612|UniProtKB=C7G3N0	Glutamate receptor, metabotropic 6	ISS	12488551	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	YEAST|SGD=S000000028|UniProtKB=P31109	Synaptobrevin homolog 1	IC			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IGI	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01451	Galpha	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05913	Enkephalin release	P05972	PKA	STRPU|EnsemblGenome=SPU_018419|UniProtKB=W4YRI6	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05755	Gbeta	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	ORNAN|Ensembl=ENSOANG00000000514|UniProtKB=F7CVF2	Uncharacterized protein	ISS	10851247	PubMed	PTHR11647:SF58	DIHYDROPYRIMIDINASE-RELATED PROTEIN 5
P00006	Apoptosis signaling pathway	P00314	MKK3	MACMU|Ensembl=ENSMMUG00000010904|UniProtKB=F7GLY5	Uncharacterized protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00054	Toll receptor signaling pathway	P01345	IKKalpha	CANLF|Ensembl=ENSCAFG00000009588|UniProtKB=E2RNA9	Uncharacterized protein	ISS	12813046	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05913	Enkephalin release	P05974	G-Protein (i)	MONDO|Ensembl=ENSMODG00000000771|UniProtKB=F6SSS3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00049	Parkinson disease	P01227	20S proteasome	CHICK|Ensembl=ENSGALG00000001597|UniProtKB=E1BYW9	Proteasome subunit beta type	ISS	12859888	PubMed	PTHR11599:SF62	PROTEASOME SUBUNIT BETA TYPE-3
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	RAT|RGD=2342|UniProtKB=P08482	Muscarinic acetylcholine receptor M1	TAS	8100450	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g210933|UniProtKB=A7SEA7	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MOUSE|MGI=MGI=87902|UniProtKB=P68134	Actin, alpha skeletal muscle	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CAEBR|Gene=CBG05858|UniProtKB=A8X1H0	Protein CBR-EGL-19 (Fragment)	ISS	91056091	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	IDA	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04393	Ras Pathway	P04578	Rho	CHICK|Ensembl=ENSGALG00000016485|UniProtKB=O93468	GTP-binding protein	ISS	13679859	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	8262392	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00048	PI3 kinase pathway	P01189	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00014	Cholesterol biosynthesis	P00499	Farnesyl-diphosphate farnesyltransferase	YARLI|EnsemblGenome=YALI0_A10076g|UniProtKB=Q9Y753	Squalene synthase	ISS			PTHR11626:SF2	SQUALENE SYNTHASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00859	NFkappaB	MOUSE|MGI=MGI=88140|UniProtKB=Q9Z2F6	B-cell lymphoma 3 protein homolog	IDA			PTHR24118:SF51	B-CELL LYMPHOMA 3 PROTEIN
P00006	Apoptosis signaling pathway	P00264	c-IAP1,2	PANTR|Ensembl=ENSPTRG00000004212|UniProtKB=H2Q4M5	Uncharacterized protein	ISS	8552191	PubMed	PTHR10044:SF99	BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 3
P00006	Apoptosis signaling pathway	P00310	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	IDA	11292874	PubMed	PTHR10048:SF14	PI-3 KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00640	PI3K	SCHPO|PomBase=SPAC458.05|UniProtKB=P50520	Phosphatidylinositol 3-kinase vps34	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00508	Cofilin	SCHPO|PomBase=SPAC20G4.06c|UniProtKB=P78929	Cofilin	ISS			PTHR11913:SF12	CFL1 PROTEIN-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	IDA	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04393	Ras Pathway	P04558	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	IDA	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00048	PI3 kinase pathway	P01188	Gbetagamma	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00019	Endothelin signaling pathway	P00566	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00367	NFAT	MOUSE|MGI=MGI=103296|UniProtKB=P97305	Nuclear factor of activated T-cells, cytoplasmic 3	IDA	9133421	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	DROME|FlyBase=FBgn0004623|UniProtKB=P29829	Guanine nucleotide-binding protein subunit beta-2	ISS	10391901	PubMed	PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PRIPA|Gene=PPA23459|UniProtKB=H3FMF2	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00021	FGF signaling pathway	P00634	MEKK1-5	CANLF|Ensembl=ENSCAFG00000012934|UniProtKB=F1P750	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P05912	Dopamine receptor mediated signaling pathway	P05960	VAT2	MOUSE|MGI=MGI=106677|UniProtKB=Q8BRU6	Synaptic vesicular amine transporter	IC	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00010	B cell activation	P00370	NFkappaB	CHICK|Ensembl=ENSGALG00000012304|UniProtKB=Q04861	Nuclear factor NF-kappa-B p105 subunit	IDA	9133421	PubMed	PTHR24169:SF9	NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	XENTR|Xenbase=XB-GENE-478210|UniProtKB=F6V5F4	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF23	FRIZZLED-4
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06822	PRLR	MOUSE|MGI=MGI=97763|UniProtKB=Q08501	Prolactin receptor	RCA			PTHR23036:SF86	PROLACTIN RECEPTOR
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	IDA	10514528	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00736	CalDAG-GEF	PANTR|Ensembl=ENSPTRG00000003844|UniProtKB=H2Q404	Uncharacterized protein	ISS	10835426	PubMed	PTHR23113:SF16	RAS GUANYL-RELEASING PROTEIN 2
P00029	Huntington disease	G01535	PIG3	GLOVI|Gene=BAC90766|UniProtKB=Q7ND01	Quinone oxidoreductase	TAS	12932731	PubMed	PTHR43677:SF4	QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2
P00012	Cadherin signaling pathway	P00470	F-actin	DANRE|ZFIN=ZDB-GENE-000322-1|UniProtKB=Q9I8V1	Actin, alpha 1, skeletal muscle	IC	10974003	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00047	PDGF signaling pathway	P01142	p90RSK	CAEEL|WormBase=WBGene00012929|UniProtKB=Q9NAH6	Ribosomal protein S6 kinase beta	ISS			PTHR24351:SF166	RIBOSOMAL PROTEIN S6 KINASE
P00006	Apoptosis signaling pathway	P00274	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00539	14-3-3	DANRE|ZFIN=ZDB-GENE-030131-779|UniProtKB=Q7ZW20	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1	ISS	5803225	gi	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BOVIN|Gene=ACTG2|UniProtKB=Q5E9B5	Actin, gamma-enteric smooth muscle	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04393	Ras Pathway	P04558	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	IDA	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01174	Rho	HUMAN|HGNC=17382|UniProtKB=Q7Z6B7	SLIT-ROBO Rho GTPase-activating protein 1	ISS			PTHR14166:SF15	SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 1
P00034	Integrin signalling pathway	P00951	Jnk	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00019	Endothelin signaling pathway	P00566	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	HUMAN|HGNC=706|UniProtKB=O15145	Actin-related protein 2/3 complex subunit 3	ISS	12473693	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00049	Parkinson disease	P01235	Fyn kinase	HUMAN|HGNC=4037|UniProtKB=P06241	Tyrosine-protein kinase Fyn	IDA	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	DANRE|ZFIN=ZDB-GENE-041026-4|UniProtKB=F1QDH9	Uncharacterized protein	ISS	22028976	PubMed	PTHR13140:SF707	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=2141917|UniProtKB=Q8BZ03	Serine/threonine-protein kinase D2	ISS	11062248	PubMed	PTHR22968:SF12	SERINE/THREONINE-PROTEIN KINASE D2
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	CANAL|CGD=CAL0000189182|UniProtKB=P12461	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00017	DNA replication	P00527	Histones	CIOIN|Ensembl=ENSCING00000002753|UniProtKB=F7AHT0	Histone H3	ISS	12413958	PubMed	PTHR11426:SF179	HISTONE H3.3
P00057	Wnt signaling pathway	P01443	Phospholipase C	ANOGA|Gene=AgaP_AGAP009115|UniProtKB=Q7PW25	Phosphoinositide phospholipase C (Fragment)	ISS	7822322	PubMed	PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00997	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	95096035	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00005	Angiogenesis	P00223	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06852	nPKCs	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	RCA	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	HUMAN|HGNC=4587|UniProtKB=Q14957	Glutamate receptor ionotropic, NMDA 2C	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MOUSE|MGI=MGI=87904|UniProtKB=P60710	Actin, cytoplasmic 1	IDA	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P02770	Pyridoxal phosphate salvage pathway	P03121	Pyridoxal kinase	HUMAN|HGNC=8819|UniProtKB=O00764	Pyridoxal kinase	ISS	15082224	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00025	Hedgehog signaling pathway	P00688	Hedgehog	CHICK|Gene=SHH|UniProtKB=Q91035	Sonic hedgehog protein	IDA	8269518	PubMed	PTHR11889:SF36	SONIC HEDGEHOG PROTEIN
P05731	GABA-B receptor II signaling	P05754	Ggamma	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	IC	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P05915	Opioid proenkephalin pathway	P05993	AC	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	RAT|RGD=2157|UniProtKB=P29067	Beta-arrestin-2	ISS	12464600	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00045	Notch signaling pathway	P01119	NIct	RAT|RGD=3187|UniProtKB=Q07008	Neurogenic locus notch homolog protein 1	IEP	1764995	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	IDA	7600581	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P02772	Pyruvate metabolism	P03133	Pyruvate Dehydrogenase	YEAST|SGD=S000000980|UniProtKB=P16387	Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial	TAS	2684159	PubMed	PTHR11516:SF40	PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01177	P110ACT	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06009	K+ channel	MOUSE|MGI=MGI=1100509|UniProtKB=O35111	Potassium channel subfamily K member 3	ISS	11875121	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P02738	De novo purine biosynthesis	P02898	Phosphoribosylformylglycinamide  synthase	METJA|EnsemblGenome=MJ_1264|UniProtKB=Q58660	Phosphoribosylformylglycinamidine synthase subunit PurL	ISS			PTHR43555:SF1	SUBFAMILY NOT NAMED
P00015	Circadian clock system	G01497	cry	HUMAN|HGNC=2385|UniProtKB=Q49AN0	Cryptochrome-2	IEP	10428031	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	HUMAN|HGNC=4582|UniProtKB=Q16099	Glutamate receptor ionotropic, kainate 4	ISS	12778120	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P02729	Ascorbate degradation	P02849	L-xylulose kinase	PANTR|Ensembl=ENSPTRG00000014758|UniProtKB=H2QMB2	Uncharacterized protein	ISS			PTHR10196:SF57	XYLULOSE KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01411	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00034	Integrin signalling pathway	P00942	Fyn	CANLF|Ensembl=ENSCAFG00000003995|UniProtKB=E2RC09	Tyrosine-protein kinase	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02738	De novo purine biosynthesis	P02894	IMP cyclohydrolase	ECOLI|EcoGene=EG10795|UniProtKB=P15639	Bifunctional purine biosynthesis protein PurH	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P00036	Interleukin signaling pathway	P00990	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	HUMAN|HGNC=3373|UniProtKB=Q09472	Histone acetyltransferase p300	TAS	8413673	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00059	p53 pathway	G04694	p110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00019	Endothelin signaling pathway	P00567	PKG	CHICK|Ensembl=ENSGALG00000003805|UniProtKB=F1NE85	cGMP-dependent protein kinase	ISS	9099696	PubMed	PTHR24353:SF68	SUBFAMILY NOT NAMED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	TAS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	TAS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00575	furin	DROME|FlyBase=FBgn0004509|UniProtKB=P26016	Furin-like protease 1, isoforms 1/1-X/2	ISS	10956649	PubMed	PTHR42884:SF3	FURIN-LIKE PROTEASE 1, ISOFORMS 1/1-X/2
P00053	T cell activation	P01311	Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	IDA	12068308	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00029	Huntington disease	P00780	Microtubule	PRIPA|Gene=PPA21757|UniProtKB=H3FHL0	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00922	Collagen	CHICK|Gene=COL6A3|UniProtKB=P15989	Collagen alpha-3(VI) chain	IDA	10778855	PubMed	PTHR44105:SF2	COLLAGEN ALPHA-3 VI  CHAIN
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IGI	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00562	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00036	Interleukin signaling pathway	P00967	c-fos	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	TAS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P06664	Gonadotropin-releasing hormone receptor pathway	P06812	L-type Ca2+	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	RCA	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00029	Huntington disease	P00780	Microtubule	CANLF|Ensembl=ENSCAFG00000019807|UniProtKB=F2Z4P1	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	YEAST|SGD=S000005164|UniProtKB=P80210	Adenylosuccinate synthetase	IEP	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02738	De novo purine biosynthesis	P02902	ADP reductase	DANRE|ZFIN=ZDB-GENE-990415-25|UniProtKB=P79733	Ribonucleoside-diphosphate reductase subunit M2	ISS			PTHR23409:SF20	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P05730	Endogenous cannabinoid signaling	P05751	Galpha	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00047	PDGF signaling pathway	P01175	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00005	Angiogenesis	P00247	Tie2	RAT|RGD=620980|UniProtKB=D3ZCD0	Endothelial-specific receptor tyrosine kinase	ISS	1630810	PubMed	PTHR24416:SF125	ANGIOPOIETIN-1 RECEPTOR
P00051	TCA cycle	P01271	Fumarase	HUMAN|HGNC=3700|UniProtKB=P07954	Fumarate hydratase, mitochondrial	ISS	227665	gi	PTHR11444:SF1	FUMARATE HYDRATASE, MITOCHONDRIAL
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04398	p53 pathway feedback loops 2	P04665	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00012	Cadherin signaling pathway	P00477	GSK3beta	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05734	Synaptic vesicle trafficking	P05778	SNAP-25	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	RCA			PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MOUSE|MGI=MGI=1342290|UniProtKB=Q9WUT3	Ribosomal protein S6 kinase alpha-2	TAS	15526037	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00019	Endothelin signaling pathway	P00591	PLCbeta	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00021	FGF signaling pathway	P00633	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00006	Apoptosis signaling pathway	P00260	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00965	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	IC	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MOUSE|MGI=MGI=87905|UniProtKB=P68033	Actin, alpha cardiac muscle 1	IC	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000025373|UniProtKB=F6ZZG9	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00037	Ionotropic glutamate receptor pathway	P01026	KA	BOVIN|Ensembl=ENSBTAG00000033153|UniProtKB=F1MG21	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00023	General transcription regulation	P00664	TFIIH complex	PANTR|Ensembl=ENSPTRG00000003420|UniProtKB=H2Q394	General transcription factor IIH, polypeptide 1, 62kDa	ISS			PTHR12856:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 1
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000014707|UniProtKB=F7GBV2	Uncharacterized protein	ISS	8120095	PubMed	PTHR24026:SF38	CADHERIN EGF LAG SEVEN-PASS G-TYPE RECEPTOR 3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	SCHPO|PomBase=SPAC8C9.03|UniProtKB=P36600	cAMP-dependent protein kinase regulatory subunit	IC	88234494	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01160	IP3 receptor	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	IC	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00624	14-3-3	EMENI|EnsemblGenome=CADANIAG00005943|UniProtKB=Q5B4M9	1433_TRIHA 14-3-3 PROTEIN HOMOLOG (TH1433)	IGI	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00047	PDGF signaling pathway	P01160	IP3 receptor	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00005	Angiogenesis	P00184	Src	CHICK|Ensembl=ENSGALG00000003855|UniProtKB=P00523	Proto-oncogene tyrosine-protein kinase Src	ISS	8054685	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00019	Endothelin signaling pathway	P00590	IP3 R	DROME|FlyBase=FBgn0010051|UniProtKB=P29993	Inositol 1,4,5-trisphosphate receptor	ISS	9065779	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00010	B cell activation	P00384	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CAEBR|Gene=CBG05858|UniProtKB=A8X1H0	Protein CBR-EGL-19 (Fragment)	ISS	15737619	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00021	FGF signaling pathway	P00630	RKIP	ANOGA|EnsemblGenome=AGAP012962|UniProtKB=F5HM75	AGAP012962-PA	ISS			PTHR11362:SF28	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P02783	Tryptophan biosynthesis	P03206	Anthranilate synthase	HALSA|EnsemblGenome=VNG_1647G|UniProtKB=Q9HPG5	Anthranilate synthase component 1 1	ISS			PTHR11236:SF9	ANTHRANILATE SYNTHASE COMPONENT 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT4G36450|UniProtKB=O23236	Mitogen-activated protein kinase 14	ISS	10851062	PubMed	PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P00059	p53 pathway	G04694	p110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01446	Calcineurin	MACMU|Ensembl=ENSMMUG00000004599|UniProtKB=F6Q932	Serine/threonine-protein phosphatase	ISS	12015605	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Gene=PLCD4|UniProtKB=P21671	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	10934033	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00018	EGF receptor signaling pathway	P00543	ERK1-2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=282|UniProtKB=P18089	Alpha-2B adrenergic receptor	IDA	6323229	PubMed	PTHR24248:SF26	ALPHA-2B ADRENERGIC RECEPTOR
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00021	FGF signaling pathway	P00635	FRS2	RAT|RGD=1308201|UniProtKB=A0A0G2JZZ5	Protein Frs2	ISS	12571252	PubMed	PTHR21258:SF40	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00951	Jnk	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	IDA	7600581	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	HUMAN|HGNC=4579|UniProtKB=P39086	Glutamate receptor ionotropic, kainate 1	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	MACMU|Ensembl=ENSMMUG00000019112|UniProtKB=F6T8S6	N-methyl D-aspartate receptor subtype 2B	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	PANTR|Ensembl=ENSPTRG00000003699|UniProtKB=H2Q3R5	Syntaxin 3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00046	Oxidative stress response	P01131	MKP5	MACMU|Ensembl=ENSMMUG00000006227|UniProtKB=F7HLA9	Dual specificity protein phosphatase	ISS			PTHR10159:SF45	DUAL SPECIFICITY PROTEIN PHOSPHATASE 6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	MOUSE|MGI=MGI=1329031|UniProtKB=O89093	C-C motif chemokine 20	IDA	12067311	PubMed	PTHR12015:SF108	C-C MOTIF CHEMOKINE 20
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00022	General transcription by RNA polymerase I	P00652	RNA Polymerase I  Complex	PANTR|Ensembl=ENSPTRG00000007801|UniProtKB=H2QAM4	RRN3 RNA polymerase I transcription factor homolog	ISS			PTHR12790:SF0	RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN3-RELATED
P00047	PDGF signaling pathway	P01142	p90RSK	BOVIN|Ensembl=ENSBTAG00000021741|UniProtKB=F1MNR5	Ribosomal protein S6 kinase	ISS	1922062	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	MACMU|Ensembl=ENSMMUG00000014817|UniProtKB=F6VXD8	Uncharacterized protein	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00705	Gsalpha	MACMU|Ensembl=ENSMMUG00000010266|UniProtKB=F6PV18	Uncharacterized protein	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04393	Ras Pathway	P04559	Rac	MOUSE|MGI=MGI=2180784|UniProtKB=P60764	Ras-related C3 botulinum toxin substrate 3	ISS	15470041	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00021	FGF signaling pathway	P00647	SHP2	DANRE|ZFIN=ZDB-GENE-030131-5911|UniProtKB=F1QZU5	Tyrosine-protein phosphatase non-receptor type	ISS	1382983	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00047	PDGF signaling pathway	P01148	Grb2	MOUSE|MGI=MGI=1333854|UniProtKB=Q9Z1S8	GRB2-associated-binding protein 2	ISS			PTHR12156:SF4	GRB2-ASSOCIATED-BINDING PROTEIN 2
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00941	Integrin alpha	BOVIN|Gene=ITGAV|UniProtKB=P80746	Integrin alpha-V	IPI	3487386	PubMed	PTHR23220:SF4	INTEGRIN ALPHA-V
P00018	EGF receptor signaling pathway	P00561	STAT	CAEEL|WormBase=WBGene00013111|UniProtKB=Q9NAD6	Signal transducer and activator of transcription 1	ISS			PTHR11801:SF43	SIGNAL TRANSDUCER AND TRANSCRIPTION ACTIVATOR
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00550	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	12748278	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00049	Parkinson disease	P01234	GRK	MONDO|Ensembl=ENSMODG00000010516|UniProtKB=F7DR73	Protein-serine/threonine kinase	ISS	10852916	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_114976|UniProtKB=C3YP58	Putative uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P05916	Opioid prodynorphin pathway	P06000	vasopressin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=1310328|UniProtKB=G3V8N1	Protein Pcdhb22	ISS	8120095	PubMed	PTHR24028:SF97	PROTOCADHERIN BETA-15
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CAEBR|Gene=CBG02162|UniProtKB=A8WS33	Protein CBG02162	ISS	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00006	Apoptosis signaling pathway	P00310	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00584	Gs	DROME|FlyBase=FBgn0001123|UniProtKB=P20354	G protein alpha s subunit	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00006	Apoptosis signaling pathway	P00274	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05913	Enkephalin release	P05972	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00318	PKCs	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00219	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	ISS	8170357	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00012	Cadherin signaling pathway	P00475	Frizzled	MOUSE|MGI=MGI=108474|UniProtKB=Q61089	Frizzled-6	IDA	8717036	PubMed	PTHR11309:SF75	FRIZZLED-6
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	CHICK|Ensembl=ENSGALG00000010273|UniProtKB=P48463	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01182	Ras	YEAST|SGD=S000005627|UniProtKB=P01119	Ras-like protein 1	ISS	7997267	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00967	c-fos	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	TAS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04397	p53 pathway by glucose deprivation	P04640	p53	BOVIN|Ensembl=ENSBTAG00000015460|UniProtKB=F1MKA9	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00056	VEGF signaling pathway	P01413	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	14526383	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DICDI|dictyBase=DDB_G0269234|UniProtKB=P07830	Major actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IDA	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	RCA	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00006	Apoptosis signaling pathway	P00318	PKCs	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	PANTR|Ensembl=ENSPTRG00000010617|UniProtKB=H2QFL8	Notch 3	ISS	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	CHICK|Ensembl=ENSGALG00000007509|UniProtKB=F1NM72	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	RAT|RGD=1304556|UniProtKB=P63259	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MONDO|Ensembl=ENSMODG00000008086|UniProtKB=F6YJ34	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00029	Huntington disease	P00807	Actin	CHICK|Ensembl=ENSGALG00000011086|UniProtKB=P68139	Actin, alpha skeletal muscle	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	ANOGA|EnsemblGenome=AGAP002578|UniProtKB=F5HKU8	AGAP002578-PB	ISS	8386525	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P00034	Integrin signalling pathway	P00924	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=99401|UniProtKB=Q60612	Adenosine receptor A1	ISS	12515326	PubMed	PTHR24246:SF1	ADENOSINE RECEPTOR A1
P00010	B cell activation	P00367	NFAT	MOUSE|MGI=MGI=1920431|UniProtKB=Q8K120	Nuclear factor of activated T-cells, cytoplasmic 4	IDA	9133421	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00018	EGF receptor signaling pathway	P00565	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00047	PDGF signaling pathway	P01151	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04657	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000023940|UniProtKB=F6RFW8	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00021	FGF signaling pathway	P00648	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P04393	Ras Pathway	P04570	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS			PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000004690|UniProtKB=Q5F3W3	Mitogen-activated protein kinase 6	ISS	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00019	Endothelin signaling pathway	P00586	Gq	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00037	Ionotropic glutamate receptor pathway	P01001	KA4	RAT|RGD=2734|UniProtKB=Q01812	Glutamate receptor ionotropic, kainate 4	IEA	11319238	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	14526383	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00057	Wnt signaling pathway	P01443	Phospholipase C	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00010	B cell activation	P00384	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	IDA	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CANLF|Ensembl=ENSCAFG00000013148|UniProtKB=Q5R1P3	Glutamate receptor ionotropic, NMDA 2B	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	PANTR|Ensembl=ENSPTRG00000005793|UniProtKB=H2REV2	Uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF139	CASEIN KINASE I ISOFORM ALPHA-LIKE
P00045	Notch signaling pathway	P01120	NIcs	PANTR|Ensembl=ENSPTRG00000034379|UniProtKB=H2RDK4	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P02727	Androgen/estrogene/progesterone biosynthesis	P02833	3beta-Hydroxysteroid dehydrogenase	MOUSE|MGI=MGI=96234|UniProtKB=P26149	3 beta-hydroxysteroid dehydrogenase/Delta 5--4-isomerase type 2	IPI	1924345	PubMed	PTHR10366:SF364	3 BETA-HYDROXYSTEROID DEHYDROGENASE/DELTA 5--4-ISOMERASE TYPE 2
P05918	p38 MAPK pathway	P06038	TRAF6	MOUSE|MGI=MGI=108072|UniProtKB=P70196	TNF receptor-associated factor 6	RCA			PTHR10131:SF111	TNF RECEPTOR-ASSOCIATED FACTOR 6
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00057	Wnt signaling pathway	P01465	Ggamma	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00019	Endothelin signaling pathway	P00591	PLCbeta	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	10395542	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00021	FGF signaling pathway	P00636	FGFR1-4	RAT|RGD=620713|UniProtKB=Q04589	Fibroblast growth factor receptor 1	IGI	9763444	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P00049	Parkinson disease	P01214	CHIP	DROME|FlyBase=FBgn0027052|UniProtKB=Q9XYW6	CHIP ortholog	IDA	12150907	PubMed	PTHR44284:SF1	E3 UBIQUITIN-PROTEIN LIGASE CHIP
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	PANTR|Ensembl=ENSPTRG00000013189|UniProtKB=H2QJV1	Uncharacterized protein	ISS	9756087	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00056	VEGF signaling pathway	P01425	PKC	MONDO|Ensembl=ENSMODG00000008318|UniProtKB=F7FGD2	Serine/threonine-protein kinase	ISS	12676944	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P00057	Wnt signaling pathway	P01443	Phospholipase C	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P06211	BMP/activin signaling pathway-drosophila	P06245	R-Smad	DROME|FlyBase=FBgn0011648|UniProtKB=P42003	Protein mothers against dpp	RCA	7768443	PubMed	PTHR13703:SF40	PROTEIN MOTHERS AGAINST DPP
P00053	T cell activation	P01310	Lck	MOUSE|MGI=MGI=96756|UniProtKB=P06240	Proto-oncogene tyrosine-protein kinase LCK	ISS	11078745	PubMed	PTHR24418:SF39	TYROSINE-PROTEIN KINASE LCK
P00022	General transcription by RNA polymerase I	P00652	RNA Polymerase I  Complex	HUMAN|HGNC=20422|UniProtKB=Q9Y2S0	DNA-directed RNA polymerases I and III subunit RPAC2	IGI	12446911	PubMed	PTHR13946:SF28	DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CAEEL|WormBase=WBGene00001679|UniProtKB=P17343	Guanine nucleotide-binding protein subunit beta-1	IC	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00047	PDGF signaling pathway	P01152	RasGAP	HUMAN|HGNC=9871|UniProtKB=P20936	Ras GTPase-activating protein 1	ISS	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00029	Huntington disease	P00796	Kainate receptor	ORNAN|Ensembl=ENSOANG00000010302|UniProtKB=F6TDQ6	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00034	Integrin signalling pathway	P00944	Actin	PUCGT|EnsemblGenome=PGTG_05488|UniProtKB=E3K4I1	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00047	PDGF signaling pathway	P01171	PLCgamma	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00056	VEGF signaling pathway	P01417	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00048	PI3 kinase pathway	P01188	Gbetagamma	ANOGA|EnsemblGenome=AGAP005911|UniProtKB=Q7Q6D4	AGAP005911-PA	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04372	5-Hydroxytryptamine degredation	P04401	Monoamine Oxidase	HUMAN|HGNC=6833|UniProtKB=P21397	Amine oxidase [flavin-containing] A	ISS	8602220	PubMed	PTHR43563:SF3	AMINE OXIDASE  FLAVIN-CONTAINING  A
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	MOUSE|MGI=MGI=103249|UniProtKB=P62204	Calmodulin	ISS	10487978	PubMed	PTHR23050:SF311	CALMODULIN
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	BOVIN|Gene=SLC18A2|UniProtKB=Q27963	Synaptic vesicular amine transporter	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00048	PI3 kinase pathway	P01199	Galpha	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IC	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00029	Huntington disease	P00774	Dynein complex	ANOGA|EnsemblGenome=AGAP011441|UniProtKB=Q7Q319	AGAP011441-PA	IPI	9454836	PubMed	PTHR10676:SF255	DYNEIN HEAVY CHAIN 12, AXONEMAL
P00053	T cell activation	P01322	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=1354946|UniProtKB=Q61532	Mitogen-activated protein kinase 6	IC	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00006	Apoptosis signaling pathway	P00274	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	ORNAN|Ensembl=ENSOANG00000015117|UniProtKB=F6XTG1	Uncharacterized protein	ISS	11055438	PubMed	PTHR10117:SF8	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=620146|UniProtKB=O08874	Serine/threonine-protein kinase N2	ISS	11880265	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TAKRU|Ensembl=ENSTRUG00000005494|UniProtKB=P53483	Actin, alpha anomalous	IC	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04398	p53 pathway feedback loops 2	P04665	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04393	Ras Pathway	P04558	p38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	DANRE|ZFIN=ZDB-GENE-041026-4|UniProtKB=F1QDH9	Uncharacterized protein	ISS	22028976	PubMed	PTHR13140:SF707	SUBFAMILY NOT NAMED
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BOVIN|Ensembl=ENSBTAG00000006189|UniProtKB=P63258	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00017	DNA replication	P00527	Histones	STRPU|EnsemblGenome=SPU_018569|UniProtKB=W4YRY4	Histone H3	ISS	12413958	PubMed	PTHR11426:SF20	HISTONE H3-LIKE CENTROMERIC PROTEIN A
P00012	Cadherin signaling pathway	P00470	F-actin	TRIAD|EnsemblGenome=TriadG63375|UniProtKB=B3S5E4	Non-muscle actin 6.2	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04393	Ras Pathway	P04553	PAK	HUMAN|HGNC=8591|UniProtKB=Q13177	Serine/threonine-protein kinase PAK 2	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P04393	Ras Pathway	P04572	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	RAT|RGD=2059|UniProtKB=P18090	Beta-1 adrenergic receptor	IDA	12730078	PubMed	PTHR24248:SF54	BETA-1 ADRENERGIC RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MOUSE|MGI=MGI=894644|UniProtKB=Q8CC27	Voltage-dependent L-type calcium channel subunit beta-2	IC	20088160	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MOUSE|MGI=MGI=96283|UniProtKB=P30966	5-hydroxytryptamine receptor 5A	IDA			PTHR24247:SF108	5-HYDROXYTRYPTAMINE RECEPTOR 5A
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	MACMU|Ensembl=ENSMMUG00000014334|UniProtKB=F7CYY6	Uncharacterized protein	ISS	11861492	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	BOVIN|Ensembl=ENSBTAG00000006495|UniProtKB=P11017	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	2372396	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	TAS	7600581	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	MACMU|Ensembl=ENSMMUG00000015658|UniProtKB=F7AJI7	Uncharacterized protein	ISS	11081635	PubMed	PTHR15071:SF17	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=1336171|UniProtKB=Q9DAS9	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P04398	p53 pathway feedback loops 2	P04669	ATM	MOUSE|MGI=MGI=108028|UniProtKB=Q9JKK8	Serine/threonine-protein kinase ATR	ISS	10196661	PubMed	PTHR11139:SF69	SERINE/THREONINE-PROTEIN KINASE ATR
P00036	Interleukin signaling pathway	P00981	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00786	ARF	DANRE|ZFIN=ZDB-GENE-010724-5|UniProtKB=Q803D1	ADP-ribosylation factor 1	ISS	12932731	PubMed	PTHR11711:SF294	ADP-RIBOSYLATION FACTOR 3
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TAKRU|Ensembl=ENSTRUG00000014318|UniProtKB=H2UI49	Uncharacterized protein	IC	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MACMU|Ensembl=ENSMMUG00000001353|UniProtKB=F7D6T8	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00034	Integrin signalling pathway	P00919	Arf6	MOUSE|MGI=MGI=99435|UniProtKB=P62331	ADP-ribosylation factor 6	ISS	12932731	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DANRE|ZFIN=ZDB-GENE-040426-1178|UniProtKB=Q7SY24	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05918	p38 MAPK pathway	P06023	MEF	CANLF|Ensembl=ENSCAFG00000008302|UniProtKB=F1PAY8	Uncharacterized protein	ISS	11274345	PubMed	PTHR11945:SF25	MYOCYTE-SPECIFIC ENHANCER FACTOR 2C
P00057	Wnt signaling pathway	P01443	Phospholipase C	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=3763|UniProtKB=P30680	Somatostatin receptor type 2	IDA	12441358	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P04398	p53 pathway feedback loops 2	P04651	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00010	B cell activation	P00391	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01420	FAK	CHICK|Ensembl=ENSGALG00000016171|UniProtKB=Q00944	Focal adhesion kinase 1	ISS	12640026	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	TAS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00644	p38	DROME|FlyBase=FBgn0015765|UniProtKB=O62618	Mitogen-activated protein kinase 14A	IGI	9417090	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000025240|UniProtKB=F7A7I3	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	TAKRU|Ensembl=ENSTRUG00000014763|UniProtKB=H2ULB2	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF728	MYOSIN HEAVY CHAIN, SKELETAL MUSCLE, ADULT
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	10693759	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01284	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	TAS	10207617	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00629	PP2A	PANTR|Ensembl=ENSPTRG00000017238|UniProtKB=H2QRH7	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IDA	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00034	Integrin signalling pathway	P00922	Collagen	PANTR|Ensembl=ENSPTRG00000006032|UniProtKB=H2RD60	Uncharacterized protein	ISS	10778855	PubMed	PTHR24023:SF588	COLLAGEN ALPHA-2 IV  CHAIN
P00018	EGF receptor signaling pathway	P00562	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IGI	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	MYCTU|EnsemblGenome=Rv0458|UniProtKB=P9WNY1	Probable aldehyde dehydrogenase	ISS			PTHR43111:SF1	ALDEHYDE DEHYDROGENASE B
P04393	Ras Pathway	P04567	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04552	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00021	FGF signaling pathway	P00642	MEK1-2	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	IC	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00005	Angiogenesis	P00221	JNK1	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	RAT|RGD=1309514|UniProtKB=D4AA42	Guanine nucleotide binding protein, alpha transducing 2 (Predicted), isoform CRA_b	ISS	10188796	PubMed	PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P05915	Opioid proenkephalin pathway	P05994	G-protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	RAT|RGD=3425|UniProtKB=P97887	Presenilin-1	IDA	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P06587	Nicotine pharmacodynamics pathway	P06602	PPP1CA	DAPPU|EnsemblGenome=DAPPUDRAFT_194510|UniProtKB=E9G7U7	Serine/threonine-protein phosphatase (Fragment)	ISS	10433257	PubMed	PTHR11668:SF282	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-BETA CATALYTIC SUBUNIT
P00057	Wnt signaling pathway	P01457	GBeta	ANOGA|EnsemblGenome=AGAP005911|UniProtKB=Q7Q6D4	AGAP005911-PA	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00053	T cell activation	P01316	MHC-antigen	MOUSE|MGI=MGI=95921|UniProtKB=P28078	Class II histocompatibility antigen, M alpha chain	IPI	73139	PubMed	PTHR19944:SF50	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DM ALPHA CHAIN
P00020	FAS signaling pathway	P00610	MKK4	MACMU|Ensembl=ENSMMUG00000019842|UniProtKB=F7FU91	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00046	Oxidative stress response	P01138	MKK4	MOUSE|MGI=MGI=1346875|UniProtKB=O08648	Mitogen-activated protein kinase kinase kinase 4	TAS	11730323	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00053	T cell activation	P01332	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04633	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00807	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g169611|UniProtKB=A7SEB1	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04393	Ras Pathway	P04570	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00973	PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01171	PLCgamma	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	IC	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01451	Galpha	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	XENTR|Xenbase=XB-GENE-868293|UniProtKB=F6UQZ6	Uncharacterized protein	ISS	12888804	PubMed	PTHR43940:SF4	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT DELTA
P00053	T cell activation	P01319	PAK	RAT|RGD=3250|UniProtKB=P35465	Serine/threonine-protein kinase PAK 1	ISS	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00021	FGF signaling pathway	P00641	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00054	Toll receptor signaling pathway	P01352	p38	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	ISS	20451058	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P02747	Histidine biosynthesis	P02988	Histidinal dehydrogenase	ARATH|TAIR=AT5G63890|UniProtKB=Q9C5U8	Histidinol dehydrogenase, chloroplastic	ISS			PTHR21256:SF2	HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	IC	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	BOVIN|Ensembl=ENSBTAG00000016751|UniProtKB=E1BPK6	Uncharacterized protein	ISS			PTHR13140:SF706	UNCONVENTIONAL MYOSIN-VI
P00037	Ionotropic glutamate receptor pathway	P01023	CaMKII	MOUSE|MGI=MGI=88256|UniProtKB=P11798	Calcium/calmodulin-dependent protein kinase type II subunit alpha	ISS	10092204	PubMed	PTHR43940:SF5	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	BOVIN|Ensembl=ENSBTAG00000011579|UniProtKB=F1N5C5	Muscarinic acetylcholine receptor	ISS	11166329	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IC	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00021	FGF signaling pathway	P00636	FGFR1-4	PANTR|Ensembl=ENSPTRG00000015836|UniProtKB=H2QP39	Fibroblast growth factor receptor	ISS	94209351	PubMed	PTHR24416:SF505	FIBROBLAST GROWTH FACTOR RECEPTOR 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000003236|UniProtKB=F7DNS6	Uncharacterized protein	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00005	Angiogenesis	P00223	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	RAT|RGD=2027|UniProtKB=P63269	Actin, gamma-enteric smooth muscle	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P04371	5-Hydroxytryptamine biosynthesis	P04400	Aromatic L-amino acid decarboxylase	PANTR|Ensembl=ENSPTRG00000019189|UniProtKB=H2QUK8	Uncharacterized protein	ISS	90339966	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00054	Toll receptor signaling pathway	P01369	MKK1	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00053	T cell activation	P01322	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MACMU|Ensembl=ENSMMUG00000011588|UniProtKB=F6PM91	Uncharacterized protein	ISS			PTHR13140:SF306	UNCONVENTIONAL MYOSIN-IXB
P00006	Apoptosis signaling pathway	P00274	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00060	Ubiquitin proteasome pathway	P01491	E2	RAT|RGD=1307886|UniProtKB=D3ZDK2	Ubiquitin-conjugating enzyme E2 D1	ISS			PTHR24068:SF36	UBIQUITIN-CONJUGATING ENZYME E2 D1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g187791|UniProtKB=A7SB93	Predicted protein	ISS			PTHR24070:SF263	RAS-LIKE PROTEIN 3
P00053	T cell activation	P01335	jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	11840290	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CAEEL|WormBase=WBGene00000065|UniProtKB=P0DM42	Actin-3	IDA	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00029	Huntington disease	P00774	Dynein complex	CHLRE|EnsemblGenome=CHLREDRAFT_130849|UniProtKB=A8J336	Flagellar outer dynein arm heavy chain alpha	IPI	9454836	PubMed	PTHR10676:SF252	SUBFAMILY NOT NAMED
P00046	Oxidative stress response	P01135	p38	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00034	Integrin signalling pathway	P00927	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	4757952	gi	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00048	PI3 kinase pathway	P01192	p110	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00056	VEGF signaling pathway	P01411	Ras	CHICK|Ensembl=ENSGALG00000014033|UniProtKB=E1BTS2	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00029	Huntington disease	P00780	Microtubule	BATDJ|Gene=BATDEDRAFT_37213|UniProtKB=F4P7H8	Alpha-Beta tubulin	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000000365|UniProtKB=F6R9F4	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00056	VEGF signaling pathway	P01423	p38MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	MACMU|Ensembl=ENSMMUG00000023046|UniProtKB=F6V829	Uncharacterized protein	ISS	11431030	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	TAS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00036	Interleukin signaling pathway	P00983	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00008	Axon guidance mediated by Slit/Robo	P00345	Mena	RAT|RGD=1307666|UniProtKB=A0A0G2K6I4	Protein Enah	ISS			PTHR11202:SF1	PROTEIN ENABLED HOMOLOG
P04393	Ras Pathway	P04558	p38	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	IDA	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	11204774	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00059	p53 pathway	P04630	PP2A	TAKRU|Ensembl=ENSTRUG00000008018|UniProtKB=H2T5N4	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	EMENI|EnsemblGenome=CADANIAG00004263|UniProtKB=Q8TFN0	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00057	Wnt signaling pathway	P01465	Ggamma	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P05915	Opioid proenkephalin pathway	P05994	G-protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	IC	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P02738	De novo purine biosynthesis	P02889	dGDP kinase	HALSA|EnsemblGenome=VNG_1160G|UniProtKB=P61136	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	11035810	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00049	Parkinson disease	P01211	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00045	Notch signaling pathway	P01110	Presenilin	DROME|FlyBase=FBgn0019947|UniProtKB=O02194	Presenilin homolog	TAS	12369105	PubMed	PTHR10202:SF13	PRESENILIN-2
P00059	p53 pathway	P01480	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00054	Toll receptor signaling pathway	G01550	Gene trancription	PANTR|Ensembl=ENSPTRG00000004284|UniProtKB=H2Q4S4	Uncharacterized protein	ISS	11331040	PubMed	PTHR45200:SF1	INTERLEUKIN-18
P04397	p53 pathway by glucose deprivation	P04641	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00029	Huntington disease	P00810	GAPDH	DAPPU|EnsemblGenome=DAPPUDRAFT_302823|UniProtKB=E9GF36	Glyceraldehyde-3-phosphate dehydrogenase	IPI			PTHR10836:SF52	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	CANLF|Ensembl=ENSCAFG00000012129|UniProtKB=E2RBX1	Protein-serine/threonine kinase	RCA			PTHR24355:SF27	G PROTEIN-COUPLED RECEPTOR KINASE 5
P00029	Huntington disease	P00807	Actin	ENTHI|EnsemblGenome=EHI_107290|UniProtKB=B1N2P0	Actin	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05730	Endogenous cannabinoid signaling	P05746	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IC	9860142	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04393	Ras Pathway	P04559	Rac	MONDO|Ensembl=ENSMODG00000003244|UniProtKB=F6THF0	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00252	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8479536	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00019	Endothelin signaling pathway	P00570	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00048	PI3 kinase pathway	P01192	p110	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00551	Akt	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	ISS	12089061	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	21157398	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00053	T cell activation	P01316	MHC-antigen	PANTR|Ensembl=ENSPTRG00000018017|UniProtKB=H2RBA7	Uncharacterized protein	ISS	73139	PubMed	PTHR19944:SF54	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DQ ALPHA 2 CHAIN
P00048	PI3 kinase pathway	P01199	Galpha	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00005	Angiogenesis	P00249	PAK	HUMAN|HGNC=8592|UniProtKB=O75914	Serine/threonine-protein kinase PAK 3	ISS	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00036	Interleukin signaling pathway	P00979	MAPKAPK2	BOVIN|Ensembl=ENSBTAG00000038107|UniProtKB=F1MCX5	Uncharacterized protein	ISS	10779545	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P04398	p53 pathway feedback loops 2	P04658	PTEN	TAKRU|Ensembl=ENSTRUG00000009851|UniProtKB=H2TJ90	Uncharacterized protein	IGI	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	ISS	1482697	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	PANTR|Ensembl=ENSPTRG00000001787|UniProtKB=H2Q0T0	Phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00017	DNA replication	P00527	Histones	ORNAN|Ensembl=ENSOANG00000010147|UniProtKB=F7F5J0	Histone H3	ISS	12413958	PubMed	PTHR11426:SF168	HISTONE H3.2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00514	MLCK	HUMAN|HGNC=29826|UniProtKB=Q32MK0	Myosin light chain kinase 3	TAS	600922	OMIM	PTHR45411:SF1	MYOSIN LIGHT CHAIN KINASE 3
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00050	Plasminogen activating cascade	P01246	Plasmin	RAT|RGD=619893|UniProtKB=Q01177	Plasminogen	ISS	16758216	gi	PTHR24261:SF5	PLASMINOGEN
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8971|UniProtKB=O00443	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IGI	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	ORNAN|Ensembl=ENSOANG00000006877|UniProtKB=F7CQF2	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	PANTR|Ensembl=ENSPTRG00000013189|UniProtKB=H2QJV1	Uncharacterized protein	ISS	6717565	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MACMU|Ensembl=ENSMMUG00000020037|UniProtKB=F7GDJ3	Anti-Muellerian hormone type-2 receptor	ISS	9395284	PubMed	PTHR23255:SF49	ANTI-MUELLERIAN HORMONE TYPE-2 RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	RAT|RGD=1561203|UniProtKB=G3V678	Protein LOC100912534	ISS	606023	OMIM	PTHR10917:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3
P02772	Pyruvate metabolism	P03140	Pyruvate Carboxylase	HUMAN|HGNC=8636|UniProtKB=P11498	Pyruvate carboxylase, mitochondrial	NAS	12112657	PubMed	PTHR43778:SF2	PYRUVATE CARBOXYLASE, MITOCHONDRIAL
P00057	Wnt signaling pathway	P01444	Wnt	PANTR|Ensembl=ENSPTRG00000017278|UniProtKB=H2QRJ8	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IDA	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00022	General transcription by RNA polymerase I	P00649	TAF-IC	HUMAN|HGNC=11534|UniProtKB=Q15572	TATA box-binding protein-associated factor RNA polymerase I subunit C	IGI	604905	OMIM	PTHR15319:SF1	TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT C
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00009	Axon guidance mediated by netrin	P00364	cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00039	Metabotropic glutamate receptor group III pathway	P01043	AC	HUMAN|HGNC=21285|UniProtKB=Q96PN6	Adenylate cyclase type 10	IC	10915626	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P02728	Arginine biosynthesis	P02840	Argininosuccinate synthase	YEAST|SGD=S000005419|UniProtKB=P22768	Argininosuccinate synthase	ISS			PTHR11587:SF2	ARGININOSUCCINATE SYNTHASE
P00057	Wnt signaling pathway	P01465	Ggamma	MACMU|Ensembl=ENSMMUG00000010392|UniProtKB=F7ASR8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00892	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	7689150	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00030	Hypoxia response via HIF activation	P00817	TOR	MACMU|Ensembl=ENSMMUG00000012138|UniProtKB=F7GZT0	Uncharacterized protein	ISS			PTHR24082:SF196	NUCLEAR RECEPTOR ROR-GAMMA
P04393	Ras Pathway	P04578	Rho	XENTR|Xenbase=XB-GENE-478301|UniProtKB=Q6NVL3	Ras homolog gene family, member B	ISS	11973360	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ORYSJ|EnsemblGenome=OS12G0163700|UniProtKB=Q0IPW3	Os12g0163700 protein	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00576	Pre-pro ET1-4	PANTR|Ensembl=ENSPTRG00000017730|UniProtKB=H2QSB1	Uncharacterized protein	ISS	12907686	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	XENTR|Xenbase=XB-GENE-484003|UniProtKB=Q6P365	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P02729	Ascorbate degradation	P02849	L-xylulose kinase	ARATH|TAIR=AT5G49650|UniProtKB=Q949W8	Putative xylulose kinase	ISS			PTHR10196:SF57	XYLULOSE KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	CANLF|Ensembl=ENSCAFG00000024151|UniProtKB=E2R795	Tyrosine-protein kinase receptor	ISS	12644000	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DICDI|dictyBase=DDB_G0279605|UniProtKB=P34148	Rho-related protein racB	ISS	94124042	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00036	Interleukin signaling pathway	P00976	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	RAT|RGD=1305585|UniProtKB=F1LNH3	Procollagen, type VI, alpha 2, isoform CRA_a	ISS	10778855	PubMed	PTHR44172:SF1	COLLAGEN ALPHA-2 VI  CHAIN
P00001	Adrenaline and noradrenaline biosynthesis	P00071	VAT1	HUMAN|HGNC=10935|UniProtKB=Q05940	Synaptic vesicular amine transporter	ISS			PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00047	PDGF signaling pathway	P01157	MAPKAPK2	PANTR|Ensembl=ENSPTRG00000001915|UniProtKB=H2Q104	Mitogen-activated protein kinase-activated protein kinase 2	ISS	9628873	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00019	Endothelin signaling pathway	P00566	ERK	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	TAS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00045	Notch signaling pathway	P01120	NIcs	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00005	Angiogenesis	P00219	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	PANTR|Ensembl=ENSPTRG00000010386|UniProtKB=H2QF61	Tyrosine-protein kinase receptor	ISS	249616	gi	PTHR24416:SF402	INSULIN RECEPTOR
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000010266|UniProtKB=F6PV18	Uncharacterized protein	ISS	6309844	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P04398	p53 pathway feedback loops 2	G04711	SIAH-1	MOUSE|MGI=MGI=108063|UniProtKB=Q06985	E3 ubiquitin-protein ligase SIAH1B	ISS	11389839	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P06587	Nicotine pharmacodynamics pathway	P06604	SLC18A2	MOUSE|MGI=MGI=106677|UniProtKB=Q8BRU6	Synaptic vesicular amine transporter	TAS	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00053	T cell activation	P01322	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02747	Histidine biosynthesis	P02989	Phosphoribosyl AMP cyclohydrolase	BACTN|EnsemblGenome=BT_1377|UniProtKB=Q8A7Z7	Histidine biosynthesis bifunctional protein HisIE	ISS			PTHR42945:SF1	HISTIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN HISIE, CHLOROPLASTIC
P04398	p53 pathway feedback loops 2	P04665	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01275	P38	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IDA	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	PANTR|Ensembl=ENSPTRG00000004893|UniProtKB=H2Q5U4	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	RAT|RGD=1311443|UniProtKB=D3Z8L7	Ras-related protein R-Ras	ISS	7997267	PubMed	PTHR24070:SF245	RAS-RELATED PROTEIN R-RAS
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00030	Hypoxia response via HIF activation	P00825	Thioredoxin	HUMAN|HGNC=17772|UniProtKB=Q99757	Thioredoxin, mitochondrial	TAS	14526383	PubMed	PTHR43601:SF3	THIOREDOXIN, MITOCHONDRIAL
P00039	Metabotropic glutamate receptor group III pathway	P01043	AC	HUMAN|HGNC=21285|UniProtKB=Q96PN6	Adenylate cyclase type 10	IC	11744988	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	METAC|EnsemblGenome=MA_3279|UniProtKB=Q8TKW5	CTP synthase	ISS			PTHR11550:SF0	CTP SYNTHASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	MOUSE|MGI=MGI=99474|UniProtKB=Q91YI4	Beta-arrestin-2	ISS	4757780	gi	PTHR11792:SF20	BETA-ARRESTIN-2
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00021	FGF signaling pathway	P00645	Rac	ARATH|TAIR=AT5G45970|UniProtKB=Q38903	Rac-like GTP-binding protein ARAC2	ISS	12932731	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00052	TGF-beta signaling pathway	P01292	RSmads	HUMAN|HGNC=6771|UniProtKB=Q99717	Mothers against decapentaplegic homolog 5	TAS	12736218	PubMed	PTHR13703:SF36	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=3025|UniProtKB=P21917	D(4) dopamine receptor	IDA	1319557	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00305	Caspase 3	CHICK|Ensembl=ENSGALG00000010638|UniProtKB=O93417	Caspase-3	ISS	11675509	PubMed	PTHR10454:SF198	CASPASE-3
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	RCA	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	ORNAN|Ensembl=ENSOANG00000015652|UniProtKB=F7FY70	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04384	Gamma-aminobutyric acid synthesis	P04480	GABA aminotransferase	RAT|RGD=620948|UniProtKB=P50554	4-aminobutyrate aminotransferase, mitochondrial	ISS	10989446	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	BOVIN|Ensembl=ENSBTAG00000004775|UniProtKB=F1MBY1	Uncharacterized protein	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00006	Apoptosis signaling pathway	P00274	JNK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	ISS	10207617	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00025	Hedgehog signaling pathway	P00690	Cubitus interruptus	HUMAN|HGNC=4317|UniProtKB=P08151	Zinc finger protein GLI1	IDA			PTHR19818:SF2	ZINC FINGER PROTEIN GLI1
P05734	Synaptic vesicle trafficking	P05778	SNAP-25	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g210933|UniProtKB=A7SEA7	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	PANTR|Ensembl=ENSPTRG00000022064|UniProtKB=H2QYE0	Uncharacterized protein	ISS	6755374	gi	PTHR24351:SF98	RIBOSOMAL PROTEIN S6 KINASE ALPHA-6
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MACMU|Ensembl=ENSMMUG00000016675|UniProtKB=F6VTB5	Uncharacterized protein	ISS	14698601	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00018	EGF receptor signaling pathway	P00560	Raf-1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00551	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IGI	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00940	Src	BOVIN|Ensembl=ENSBTAG00000008938|UniProtKB=E1BIM8	Tyrosine-protein kinase	ISS	8054685	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	TAS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00748	Gbeta5L	CANLF|Ensembl=ENSCAFG00000015662|UniProtKB=E2RHY4	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	CAEEL|WormBase=WBGene00004287|UniProtKB=Q94124	Ras-related protein rac-2	ISS	21571425	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	RAT|RGD=620003|UniProtKB=O08773	Regulator of G-protein signaling 14	IDA	8756726	PubMed	PTHR10845:SF179	REGULATOR OF G-PROTEIN SIGNALING 14
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00018	EGF receptor signaling pathway	P00562	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02738	De novo purine biosynthesis	P02891	GDP kinase	BACSU|EnsemblGenome=BSU22730|UniProtKB=P31103	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000011757|UniProtKB=Q9XT97	Presenilin-1	IDA	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00045	Notch signaling pathway	P01103	Next	PANTR|Ensembl=ENSPTRG00000013250|UniProtKB=H2QJZ0	Delta-like protein	ISS	7697721	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00047	PDGF signaling pathway	P01154	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00048	PI3 kinase pathway	P01181	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	TAS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04393	Ras Pathway	P04556	Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	IDA	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00047	PDGF signaling pathway	P01162	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02765	Phenylalanine biosynthesis	P03099	Prephenate dehydratase	YEAST|SGD=S000005260|UniProtKB=P32452	Putative prephenate dehydratase	ISS			PTHR21022:SF0	PREPHENATE DEHYDRATASE-RELATED
P00049	Parkinson disease	P01233	Elk-1	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	14670631	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	PANTR|Ensembl=ENSPTRG00000013628|UniProtKB=H2R4F5	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00010	B cell activation	P00381	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	ISS	15737619	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	1718748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	PANTR|Ensembl=ENSPTRG00000028742|UniProtKB=H2R5M6	Uncharacterized protein	ISS			PTHR24072:SF158	RHO-RELATED GTP-BINDING PROTEIN RHOG
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05915	Opioid proenkephalin pathway	P05989	leu-Enkephalin	MACMU|Ensembl=ENSMMUG00000006775|UniProtKB=F7H3N8	Uncharacterized protein	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P04396	Vitamin D metabolism and pathway	P04603	1alpha-Hydroxylase	MOUSE|MGI=MGI=88594|UniProtKB=Q9DBG1	Sterol 26-hydroxylase, mitochondrial	IDA	11013342	PubMed	PTHR24291:SF6	STEROL 26-HYDROXYLASE, MITOCHONDRIAL
P00021	FGF signaling pathway	P00640	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	TAS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IC	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	RAT|RGD=2522|UniProtKB=P30729	D(4) dopamine receptor	IDA	2039532	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00010	B cell activation	P00386	Calcineurin	MACMU|Ensembl=ENSMMUG00000015714|UniProtKB=F6SFE0	Serine/threonine-protein phosphatase	ISS	12015605	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P05913	Enkephalin release	P05972	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	CHICK|Ensembl=ENSGALG00000007509|UniProtKB=F1NM72	Uncharacterized protein	ISS	87005246	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_114535|UniProtKB=C3ZHN2	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P05913	Enkephalin release	P05972	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	G04714	PTEN	TAKRU|Ensembl=ENSTRUG00000009851|UniProtKB=H2TJ90	Uncharacterized protein	IGI	21455682	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P06664	Gonadotropin-releasing hormone receptor pathway	P06847	JNK1/2	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	RCA	15528206	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000001384|UniProtKB=F7GL73	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05915	Opioid proenkephalin pathway	P05985	Mu or Delta receptor	MACMU|Ensembl=ENSMMUG00000009389|UniProtKB=F7HEV7	Uncharacterized protein	ISS	11259487	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IGI	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00049	Parkinson disease	P01227	20S proteasome	DANRE|ZFIN=ZDB-GENE-040426-2682|UniProtKB=Q7ZUJ8	Proteasome subunit beta type	ISS	12859888	PubMed	PTHR11599:SF62	PROTEASOME SUBUNIT BETA TYPE-3
P00006	Apoptosis signaling pathway	P00274	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9062|UniProtKB=Q9BRC7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	15611108	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00052	TGF-beta signaling pathway	P01292	RSmads	HUMAN|HGNC=6769|UniProtKB=P84022	Mothers against decapentaplegic homolog 3	TAS	9395284	PubMed	PTHR13703:SF25	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=1306856|UniProtKB=Q5DWV2	Cadherin-7	ISS	8120095	PubMed	PTHR24027:SF91	CADHERIN-7
P00029	Huntington disease	P00811	Arp2/3 complex	MONDO|Ensembl=ENSMODG00000007194|UniProtKB=F6X9N6	Actin-related protein 2/3 complex subunit 5	ISS	12473693	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00059	p53 pathway	P04630	PP2A	HUMAN|HGNC=9300|UniProtKB=P62714	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	IC	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00047	PDGF signaling pathway	P01154	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00011	Blood coagulation	P00443	Fibrin polymer cross-linked	MACMU|Ensembl=ENSMMUG00000021302|UniProtKB=F6UZ87	Uncharacterized protein	ISS	11761631	gi	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00039	Metabotropic glutamate receptor group III pathway	P01038	Vglut	HUMAN|HGNC=16704|UniProtKB=Q9P2U7	Vesicular glutamate transporter 1	ISS	15192755	PubMed	PTHR11662:SF138	VESICULAR GLUTAMATE TRANSPORTER 1
P00045	Notch signaling pathway	P01103	Next	MACMU|Ensembl=ENSMMUG00000001276|UniProtKB=F7BUF3	Delta-like protein	ISS			PTHR44097:SF1	PROTEIN JAGGED-2
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	ANOGA|EnsemblGenome=AGAP008988|UniProtKB=Q7PWF1	Glutamine synthetase	ISS			PTHR20852:SF44	GLUTAMINE SYNTHETASE 1, MITOCHONDRIAL
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	IC	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	ORYSJ|EnsemblGenome=OS06G0168600|UniProtKB=Q5VRF5	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P02721	ATP synthesis	P02796	F1 gamma	PANTR|Ensembl=ENSPTRG00000002277|UniProtKB=H2R2Y8	ATP synthase subunit gamma	ISS	9525963	PubMed	PTHR11693:SF22	ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL
P00029	Huntington disease	P00796	Kainate receptor	HUMAN|HGNC=4581|UniProtKB=Q13003	Glutamate receptor ionotropic, kainate 3	IDA	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=4600|UniProtKB=O00222	Metabotropic glutamate receptor 8	IDA	9407094	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00059	p53 pathway	P04616	PDK1/2	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	15210700	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	MOUSE|MGI=MGI=87948|UniProtKB=P46664	Adenylosuccinate synthetase isozyme 2	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00012	Cadherin signaling pathway	P00474	Wnt	CANLF|Ensembl=ENSCAFG00000031321|UniProtKB=J9NZJ2	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-040718-134|UniProtKB=Q6DH55	Guanine nucleotide binding protein (G protein), beta polypeptide 3, like	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	HUMAN|HGNC=16767|UniProtKB=Q8TCU5	Glutamate receptor ionotropic, NMDA 3A	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00004	Alzheimer disease-presenilin pathway	P00118	E-cadherin	MACMU|Ensembl=ENSMMUG00000010393|UniProtKB=F7D992	Uncharacterized protein	ISS	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IGI	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00056	VEGF signaling pathway	P01420	FAK	MONDO|Ensembl=ENSMODG00000000707|UniProtKB=F6WLE6	Uncharacterized protein	ISS	9182576	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00057	Wnt signaling pathway	P01428	Frizzled	HUMAN|HGNC=4038|UniProtKB=Q9UP38	Frizzled-1	IDA	12549854	PubMed	PTHR11309:SF81	FRIZZLED-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=621025|UniProtKB=Q62711	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	7822322	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00260	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05731	GABA-B receptor II signaling	P05754	Ggamma	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	RCA	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01284	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00045	Notch signaling pathway	P01104	Serrate	ORNAN|Ensembl=ENSOANG00000008425|UniProtKB=F6VUQ4	Delta-like protein	ISS	1286675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	TAKRU|Ensembl=ENSTRUG00000016796|UniProtKB=H2V1D3	Uncharacterized protein (Fragment)	ISS	9783586	PubMed	PTHR10814:SF24	TRANSDUCIN-LIKE ENHANCER PROTEIN 3
P02748	Isoleucine biosynthesis	P02994	Branched chain amino acid aminotransferase	DROME|FlyBase=FBgn0030482|UniProtKB=Q9VYD5	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF44	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P00054	Toll receptor signaling pathway	P01375	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00845	Cyclooxygenase	HUMAN|HGNC=9604|UniProtKB=P23219	Prostaglandin G/H synthase 1	RCA			PTHR11903:SF6	PROSTAGLANDIN G/H SYNTHASE 1
P00048	PI3 kinase pathway	P01179	PKB	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04668	p53	HUMAN|HGNC=11998|UniProtKB=P04637	Cellular tumor antigen p53	TAS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	ANOGA|Gene=AgaP_AGAP009115|UniProtKB=Q7PW25	Phosphoinositide phospholipase C (Fragment)	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06759	IRS	MOUSE|MGI=MGI=1338009|UniProtKB=Q9Z0Y7	Insulin receptor substrate 4	RCA	5031805	gi	PTHR10614:SF2	INSULIN RECEPTOR SUBSTRATE 4
P05916	Opioid prodynorphin pathway	P06002	G-protein	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P06209	ALP23B signaling pathway	P06226	PPM1A	DROME|FlyBase=FBgn0086361|UniProtKB=Q961C5	Alphabet, isoform E	IEA	http://flybase.org/reports/FBgn0086361.html	Website	PTHR13832:SF524	PROTEIN PHOSPHATASE 1A, MAGNESIUM DEPENDENT, ALPHA ISOFORM-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	10644715	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P02734	Chorismate biosynthesis	P02868	Chorismate synthase	RHOBA|EnsemblGenome=RB6822|UniProtKB=Q7UPN5	Chorismate synthase	ISS			PTHR21085:SF0	CHORISMATE SYNTHASE
P00010	B cell activation	P00402	Jnk	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT1G59580|UniProtKB=Q39022	Mitogen-activated protein kinase 2	IDA	94177172	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02779	Thiamin biosynthesis	P03173	Thiamin phosphate synthase	LEPIN|EnsemblGenome=LA_1991|UniProtKB=Q8F4P9	Thiamine phosphate pyrophosphorylase	ISS			PTHR20857:SF15	THIAMINE BIOSYNTHETIC BIFUNCTIONAL ENZYME
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	DANRE|ZFIN=ZDB-GENE-040426-2487|UniProtKB=Q803G3	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00029	Huntington disease	P00810	GAPDH	ORYSJ|EnsemblGenome=OS02G0601300|UniProtKB=Q6K5G8	Glyceraldehyde-3-phosphate dehydrogenase 3, cytosolic	ISS			PTHR10836:SF76	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE A
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	CANLF|Ensembl=ENSCAFG00000000760|UniProtKB=E2R9L4	Uncharacterized protein	ISS	12052864	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00021	FGF signaling pathway	P00641	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00059	p53 pathway	G04694	p110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	BOVIN|Ensembl=ENSBTAG00000018445|UniProtKB=E1BK87	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00019	Endothelin signaling pathway	P00587	Raf-1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00008	Axon guidance mediated by Slit/Robo	P00355	Rho	PANTR|Ensembl=ENSPTRG00000001112|UniProtKB=H2PZP2	Ras homolog gene family, member C	ISS	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00627	ERK1-2	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00557	PI3K	ARATH|TAIR=AT1G60490|UniProtKB=P42339	Phosphatidylinositol 3-kinase VPS34	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000010094|UniProtKB=H2QEN7	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF91	CADHERIN-7
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MOUSE|MGI=MGI=95283|UniProtKB=P22387	Endothelin-1	ISS	12893655	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9062|UniProtKB=Q9BRC7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	7822322	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P02788	Xanthine and guanine salvage pathway	P03249	Guanine deaminase	YEAST|SGD=S000002397|UniProtKB=Q07729	Probable guanine deaminase	ISS			PTHR11271:SF6	GUANINE DEAMINASE
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00047	PDGF signaling pathway	P01161	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00020	FAS signaling pathway	P00615	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00045	Notch signaling pathway	P01103	Next	CANLF|Ensembl=ENSCAFG00000005627|UniProtKB=E2QUR0	Delta-like protein	ISS	8955070	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	ANOGA|EnsemblGenome=AGAP001506|UniProtKB=Q7PXP3	AGAP001506-PA	IC			PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	MOUSE|MGI=MGI=106677|UniProtKB=Q8BRU6	Synaptic vesicular amine transporter	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	IC	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02770	Pyridoxal phosphate salvage pathway	P03120	Pyridoxamine-5-phosphate oxidase	PSEAE|EnsemblGenome=PA1049|UniProtKB=Q9I4S5	Pyridoxine/pyridoxamine 5'-phosphate oxidase	ISS	10984043	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P04393	Ras Pathway	P04553	PAK	CANLF|Ensembl=ENSCAFG00000013067|UniProtKB=E2RJA0	Uncharacterized protein	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01026	KA	RAT|RGD=2732|UniProtKB=P22756	Glutamate receptor ionotropic, kainate 1	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00059	p53 pathway	P01486	Akt	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	TAS	12719720	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04665	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01015	Glu4	MOUSE|MGI=MGI=95811|UniProtKB=Q9Z2W8	Glutamate receptor 4	ISS	12871085	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00018	EGF receptor signaling pathway	P00562	p38	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	IGI	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	MOUSE|MGI=MGI=1351342|UniProtKB=Q3UVX5	Metabotropic glutamate receptor 5	ISS	9407094	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00021	FGF signaling pathway	P00638	PLCgamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05916	Opioid prodynorphin pathway	P06000	vasopressin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04398	p53 pathway feedback loops 2	P04651	Ras	CAEEL|WormBase=WBGene00002335|UniProtKB=P22981	Ras protein let-60	IDA	22022015	PubMed	PTHR24070:SF385	GTPASE HRAS
P00029	Huntington disease	P00807	Actin	ORNAN|Ensembl=ENSOANG00000007581|UniProtKB=F6QWB7	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00047	PDGF signaling pathway	P01153	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-1712|UniProtKB=Q6PBY0	Guanine nucleotide binding protein (G protein), beta 5	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00046	Oxidative stress response	P01129	JNK1/2	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05916	Opioid prodynorphin pathway	P06002	G-protein	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00013	Cell cycle	P00480	Proteasome	PANTR|Ensembl=ENSPTRG00000013893|UniProtKB=H2PZY5	Uncharacterized protein	ISS	11827521	PubMed	PTHR10223:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4
P00018	EGF receptor signaling pathway	P00554	Shc	MOUSE|MGI=MGI=98296|UniProtKB=P98083	SHC-transforming protein 1	IGI	8264585	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00006	Apoptosis signaling pathway	P00310	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02777	Succinate to proprionate conversion	P03161	Methylmalonyl-CoA mutase	HALSA|EnsemblGenome=VNG_0673G|UniProtKB=Q9HRJ2	Methylmalonyl-CoA mutase	ISS			PTHR23408:SF19	SUBFAMILY NOT NAMED
P00024	Glycolysis	P00679	Aldolase	HUMAN|HGNC=414|UniProtKB=P04075	Fructose-bisphosphate aldolase A	ISS	3391172	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00020	FAS signaling pathway	P00618	CAD	PANTR|Ensembl=ENSPTRG00000000070|UniProtKB=H2PXW1	Uncharacterized protein	ISS	10739646	PubMed	PTHR13067:SF2	DNAATION FACTOR-RELATED PROTEIN 4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=621025|UniProtKB=Q62711	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	15611108	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00470	F-actin	SCHMA|EnsemblGenome=Smp_183710|UniProtKB=G4VLW1	Putative actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04580	TRH Receptor	RAT|RGD=3904|UniProtKB=Q01717	Thyrotropin-releasing hormone receptor	ISS	7509436	PubMed	PTHR24243:SF115	THYROTROPIN-RELEASING HORMONE RECEPTOR
P00019	Endothelin signaling pathway	P00572	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IGI	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	PANTR|Ensembl=ENSPTRG00000021502|UniProtKB=H2QY34	Uncharacterized protein	ISS			PTHR23359:SF102	ADENYLATE KINASE 8
P02769	Purine metabolism	P03118	Guanine Deaminase	PSEAE|EnsemblGenome=PA0134|UniProtKB=Q9I6Z8	Probable guanine deaminase	ISS	10984043	PubMed	PTHR11271:SF6	GUANINE DEAMINASE
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	HUMAN|HGNC=10935|UniProtKB=Q05940	Synaptic vesicular amine transporter	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00015	Circadian clock system	P00502	Casein kinase I	RAT|RGD=62045|UniProtKB=Q99PS2	Casein kinase1 epsilon-2	ISS	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	IPI	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014262|UniProtKB=F7BYS8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04398	p53 pathway feedback loops 2	G04714	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IGI	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	CAEEL|WormBase=WBGene00000048|UniProtKB=Q18556	AcetylCholine Receptor	IC	85270494	PubMed	PTHR18945:SF528	ACETYLCHOLINE RECEPTOR
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	RAT|RGD=621705|UniProtKB=Q8VHN2	Glutamate receptor ionotropic, NMDA 3B	ISS	11319238	PubMed	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TAKRU|Ensembl=ENSTRUG00000005494|UniProtKB=P53483	Actin, alpha anomalous	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00059	p53 pathway	P04609	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=4597|UniProtKB=P41594	Metabotropic glutamate receptor 5	IDA			PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00038	JAK/STAT signaling pathway	P01027	STAT	MACMU|Ensembl=ENSMMUG00000017527|UniProtKB=F6UMM2	Signal transducer and activator of transcription	ISS	94367369	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00010	B cell activation	P00388	PLC gamma2	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P02746	Heme biosynthesis	P02979	porphobilinogen synthase	PSEAE|EnsemblGenome=PA5243|UniProtKB=Q59643	Delta-aminolevulinic acid dehydratase	ISS			PTHR11458:SF0	DELTA-AMINOLEVULINIC ACID DEHYDRATASE
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MACMU|Ensembl=ENSMMUG00000001353|UniProtKB=F7D6T8	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00018	EGF receptor signaling pathway	P00545	JNK1-3	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IGI			PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MONDO|Ensembl=ENSMODG00000018489|UniProtKB=F7BRQ7	Uncharacterized protein	ISS			PTHR13140:SF706	UNCONVENTIONAL MYOSIN-VI
P00060	Ubiquitin proteasome pathway	P01490	E3	MOUSE|MGI=MGI=1923038|UniProtKB=Q9CUN6	E3 ubiquitin-protein ligase SMURF1	ISS	11252892	PubMed	PTHR11254:SF293	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P00011	Blood coagulation	P00408	Plasminogen	MACMU|Gene=PLG|UniProtKB=P12545	Plasminogen	ISS	130317	gi	PTHR24261:SF6	PLASMINOGEN
P00006	Apoptosis signaling pathway	P00284	Flip	MACMU|Ensembl=ENSMMUG00000012310|UniProtKB=F7DL95	CASP8 and FADD-like apoptosis regulator isoform 1	ISS	9211860	PubMed	PTHR10454:SF8	CASP8 AND FADD-LIKE APOPTOSIS REGULATOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ARATH|TAIR=AT2G42090|UniProtKB=P93738	Putative actin-9	IC	11889126	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01150	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9060|UniProtKB=P51178	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	10934033	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P02752	Mannose metabolism	P03015	GDP-Mannose 4,6-dehydratase	RAT|RGD=1311008|UniProtKB=Q3MHS7	GDP-mannose 4, 6-dehydratase	ISS	9603974	PubMed	PTHR43715:SF1	GDP-MANNOSE 4,6 DEHYDRATASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05731	GABA-B receptor II signaling	P05760	AC	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00057	Wnt signaling pathway	P01465	Ggamma	DANRE|ZFIN=ZDB-GENE-010705-1|UniProtKB=Q90Z40	Guanine nucleotide-binding protein subunit gamma	IDA	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00035	Interferon-gamma signaling pathway	P00954	Interferongamma	HUMAN|HGNC=5438|UniProtKB=P01579	Interferon gamma	TAS	11929133	PubMed	PTHR11419:SF0	INTERFERON GAMMA
P00057	Wnt signaling pathway	P01451	Galpha	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00646	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	88318957	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00005	Angiogenesis	P00219	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	ORYSJ|EnsemblGenome=OS03G0763000|UniProtKB=Q8W5G9	Casein kinase II, alpha chain, putative, expressed	IDA	10806215	PubMed	PTHR24054:SF33	CASEIN KINASE II SUBUNIT ALPHA, CHLOROPLASTIC
P00012	Cadherin signaling pathway	P00464	Fyn	MACMU|Ensembl=ENSMMUG00000017017|UniProtKB=F7FVL2	Tyrosine-protein kinase	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00015	Circadian clock system	P00501	Clock	CANLF|Ensembl=ENSCAFG00000002140|UniProtKB=F1PSD8	Uncharacterized protein	ISS	8171325	PubMed	PTHR23042:SF2	CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04395	Vasopressin synthesis	P04596	Endo Peptidase	MYCTU|EnsemblGenome=LH57_02445|UniProtKB=O07178	Peptidase	ISS	9695945	PubMed	PTHR43548:SF1	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01159	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	RCA	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00059	p53 pathway	G04694	p110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00057	Wnt signaling pathway	P01444	Wnt	BOVIN|Ensembl=ENSBTAG00000012914|UniProtKB=F1MHG3	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00049	Parkinson disease	P01216	Parkin	MOUSE|MGI=MGI=1355296|UniProtKB=Q9WVS6	E3 ubiquitin-protein ligase parkin	IDA	11078524	PubMed	PTHR11685:SF214	E3 UBIQUITIN-PROTEIN LIGASE PARKIN
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MOUSE|MGI=MGI=95777|UniProtKB=Q6R0H7	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas	IC	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P06664	Gonadotropin-releasing hormone receptor pathway	P06706	AdipoR1/R2	MOUSE|MGI=MGI=93830|UniProtKB=Q8BQS5	Adiponectin receptor protein 2	RCA			PTHR20855:SF33	ADIPONECTIN RECEPTOR PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	PANTR|Ensembl=ENSPTRG00000001108|UniProtKB=H2PZP0	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00053	T cell activation	P01307	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IPI	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00005	Angiogenesis	P00219	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00018	EGF receptor signaling pathway	P00551	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	IGI	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02746	Heme biosynthesis	P02979	porphobilinogen synthase	PYRAE|EnsemblGenome=PAE0583|UniProtKB=Q8ZYW5	Delta-aminolevulinic acid dehydratase	ISS			PTHR11458:SF0	DELTA-AMINOLEVULINIC ACID DEHYDRATASE
P00009	Axon guidance mediated by netrin	P00358	Ablim	CHICK|Ensembl=ENSGALG00000009048|UniProtKB=E1BS96	Uncharacterized protein	ISS	602330	OMIM	PTHR24213:SF18	ACTIN-BINDING LIM PROTEIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CHICK|Ensembl=ENSGALG00000011809|UniProtKB=F1NMB0	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00005	Angiogenesis	P00189	Fzd	MACMU|Ensembl=ENSMMUG00000022114|UniProtKB=F7H7V5	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF81	FRIZZLED-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00017	DNA replication	P00527	Histones	BOVIN|Ensembl=ENSBTAG00000024003|UniProtKB=E1BGN3	Histone H3	ISS	12413958	PubMed	PTHR11426:SF180	SUBFAMILY NOT NAMED
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00005	Angiogenesis	P00223	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00521	Profilin	CHLRE|EnsemblGenome=CHLREDRAFT_181887|UniProtKB=Q94KS3	Profilin	ISS			PTHR11604:SF0	PROFILIN
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	RAT|RGD=2027|UniProtKB=P63269	Actin, gamma-enteric smooth muscle	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02778	Sulfate assimilation	P03167	Sulfate adenylyltransferase	PYRAE|EnsemblGenome=PAE2609|UniProtKB=Q8ZUU0	Sulfate adenylyltransferase	ISS			PTHR43509:SF1	SUBFAMILY NOT NAMED
P06959	CCKR signaling map	P07025	HBEGF	HUMAN|HGNC=3059|UniProtKB=Q99075	Proheparin-binding EGF-like growth factor	RCA	9869605	PubMed	PTHR10740:SF4	PROHEPARIN-BINDING EGF-LIKE GROWTH FACTOR
P00045	Notch signaling pathway	G01541	E(spl)-C genes	HUMAN|HGNC=33783|UniProtKB=A6NFD8	Hairy and enhancer of split-related protein HELT	IC			PTHR10985:SF8	HAIRY AND ENHANCER OF SPLIT-RELATED PROTEIN HELT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	PANTR|Ensembl=ENSPTRG00000005438|UniProtKB=H2RBJ1	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00005	Angiogenesis	P00206	Wnt	MONDO|Ensembl=ENSMODG00000001196|UniProtKB=F7GH85	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	YEAST|SGD=S000005042|UniProtKB=P01120	Ras-like protein 2	ISS	7997267	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	ARATH|TAIR=AT3G08530|UniProtKB=Q0WLB5	Clathrin heavy chain 2	IDA	9388255	PubMed	PTHR10292:SF1	CLATHRIN HEAVY CHAIN
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	BOVIN|Ensembl=ENSBTAG00000037429|UniProtKB=F1MGM3	Uncharacterized protein	ISS	11701344	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P06664	Gonadotropin-releasing hormone receptor pathway	P06750	MIS	MOUSE|MGI=MGI=88006|UniProtKB=P27106	Muellerian-inhibiting factor	RCA			PTHR15009:SF4	MUELLERIAN-INHIBITING FACTOR
P00010	B cell activation	P00388	PLC gamma2	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00020	FAS signaling pathway	P00601	c-Jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00021	FGF signaling pathway	P00644	p38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IGI	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00037	Ionotropic glutamate receptor pathway	P01026	KA	BOVIN|Ensembl=ENSBTAG00000009269|UniProtKB=F1MCM2	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	PANTR|Ensembl=ENSPTRG00000014711|UniProtKB=H2QZF5	TGF-beta receptor type-2	ISS	9759503	PubMed	PTHR23255:SF55	TGF-BETA RECEPTOR TYPE-2
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P02753	Methionine biosynthesis	P03024	Homocysteine transmethylase	STRCO|Gene=CAD55372|UniProtKB=Q8CJP1	Putative transferase	ISS			PTHR21091:SF123	FI01821P
P05915	Opioid proenkephalin pathway	P05994	G-protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00057	Wnt signaling pathway	P01444	Wnt	RAT|RGD=621463|UniProtKB=G3V819	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00636	FGFR1-4	PANTR|Ensembl=ENSPTRG00000020176|UniProtKB=H2R210	Fibroblast growth factor receptor	ISS	9989949	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P00005	Angiogenesis	P00205	GAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00057	Wnt signaling pathway	P01453	Ebi	MONDO|Ensembl=ENSMODG00000022806|UniProtKB=H9H985	Uncharacterized protein (Fragment)	ISS	11389839	PubMed	PTHR22846:SF40	F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN TBL1XR1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00034	Integrin signalling pathway	P00936	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00020	FAS signaling pathway	P00615	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00029	Huntington disease	P00805	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	HUMAN|HGNC=9508|UniProtKB=P49768	Presenilin-1	TAS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IGI	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00006	Apoptosis signaling pathway	P00274	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	NEUCR|EnsemblGenome=EFNCRG00000007504|UniProtKB=Q9C167	Ribonucleoside-diphosphate reductase small chain	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00050	Plasminogen activating cascade	P01247	TAFI	RAT|RGD=71035|UniProtKB=Q9EQV9	Carboxypeptidase B2	IDA	11021404	PubMed	PTHR11705:SF17	CARBOXYPEPTIDASE B2
P00049	Parkinson disease	P01237	Complex I	STRCO|Gene=CAB44527|UniProtKB=Q9XAQ8	NuoE, NADH dehydrogenase subunit	ISS			PTHR10371:SF3	NADH DEHYDROGENASE  UBIQUINONE  FLAVOPROTEIN 2, MITOCHONDRIAL
P00021	FGF signaling pathway	P00645	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00114	actin	NEUCR|EnsemblGenome=EFNCRG00000003893|UniProtKB=P78711	Actin	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	G04699	BAI-1	HUMAN|HGNC=945|UniProtKB=O60242	Adhesion G protein-coupled receptor B3	ISS			PTHR12011:SF40	ADHESION G PROTEIN-COUPLED RECEPTOR B3
P00029	Huntington disease	P00780	Microtubule	ORNAN|Ensembl=ENSOANG00000004061|UniProtKB=F6TYN8	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P00021	FGF signaling pathway	P00641	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P02770	Pyridoxal phosphate salvage pathway	P03121	Pyridoxal kinase	DEIRA|EnsemblGenome=DR_A0184|UniProtKB=Q9RYX0	Pyridoxal kinase PdxY	ISS	10567266	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P00006	Apoptosis signaling pathway	P00291	MEKK1	MACMU|Ensembl=ENSMMUG00000012387|UniProtKB=F7EB20	Uncharacterized protein	ISS	8643568	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	HUMAN|HGNC=1950|UniProtKB=P11229	Muscarinic acetylcholine receptor M1	TAS	12181435	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P04396	Vitamin D metabolism and pathway	P04603	1alpha-Hydroxylase	MACMU|Ensembl=ENSMMUG00000015762|UniProtKB=F6RYQ8	Uncharacterized protein	ISS	11013342	PubMed	PTHR24291:SF9	CYTOCHROME P450 27C1
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	RAT|RGD=620325|UniProtKB=Q78EH2	Proprotein convertase subtilisin/kexin type 4	IDA			PTHR42884:SF16	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	P01464	Pygo	PANTR|Ensembl=ENSPTRG00000001395|UniProtKB=H2Q058	Pygopus homolog 2	ISS	11955446	PubMed	PTHR23194:SF7	PYGOPUS HOMOLOG 2
P00034	Integrin signalling pathway	P00936	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00049	Parkinson disease	P01208	Hsp70	ECOLI|EcoGene=EG10241|UniProtKB=P0A6Y8	Chaperone protein DnaK	ISS	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P00021	FGF signaling pathway	P00627	ERK1-2	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02783	Tryptophan biosynthesis	P03206	Anthranilate synthase	PSEAE|EnsemblGenome=PA0609|UniProtKB=P20580	Anthranilate synthase component 1	ISS			PTHR11236:SF9	ANTHRANILATE SYNTHASE COMPONENT 1
P06587	Nicotine pharmacodynamics pathway	P06598	EPB41L2	MACMU|Ensembl=ENSMMUG00000007758|UniProtKB=F7BWK5	Uncharacterized protein	ISS	12181426	PubMed	PTHR23280:SF17	BAND 4.1-LIKE PROTEIN 2
P00055	Transcription regulation by bZIP transcription factor	P01395	TFIIE	PANTR|Ensembl=ENSPTRG00000015273|UniProtKB=H2QN66	General transcription factor IIE, polypeptide 1, alpha 56kDa	ISS	189964	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00018	EGF receptor signaling pathway	P00564	Rac	DICPU|Gene=DICPUDRAFT_92985|UniProtKB=F1A084	Putative uncharacterized protein rac1A	ISS	8649368	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00048	PI3 kinase pathway	P01192	p110	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00636	FGFR1-4	BOVIN|Ensembl=ENSBTAG00000015457|UniProtKB=A4IFL5	Fibroblast growth factor receptor	ISS	12799194	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BOVIN|Gene=ACTB|UniProtKB=P60712	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IDA	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04391	Oxytocin receptor mediated signaling pathway	P04531	Oxytocin Receptor	MOUSE|MGI=MGI=109147|UniProtKB=P97926	Oxytocin receptor	ISS	11006161	PubMed	PTHR24241:SF19	OXYTOCIN RECEPTOR
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	STRCO|Gene=CAB94610|UniProtKB=Q9K3C2	Ribonucleoside-diphosphate reductase subunit beta	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00546	GAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	IGI	8262392	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P06959	CCKR signaling map	G07269	REG1A	HUMAN|HGNC=9951|UniProtKB=P05451	Lithostathine-1-alpha	RCA	17463184	PubMed	PTHR43993:SF7	LITHOSTATHINE-1-ALPHA
P06664	Gonadotropin-releasing hormone receptor pathway	P06736	CLIM2	MOUSE|MGI=MGI=894762|UniProtKB=P70662	LIM domain-binding protein 1	RCA			PTHR10378:SF7	LIM DOMAIN-BINDING PROTEIN 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00590	IP3 R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01431	LRP5/6	MACMU|Ensembl=ENSMMUG00000023317|UniProtKB=F6Y514	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P05916	Opioid prodynorphin pathway	P06003	dynorphin	MACMU|Ensembl=ENSMMUG00000009984|UniProtKB=F6R267	Beta-neoendorphin-dynorphin	ISS	131330	OMIM	PTHR11438:SF4	PROENKEPHALIN-B
P04397	p53 pathway by glucose deprivation	P04641	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00058	mRNA splicing	P01473	U6	HUMAN|HGNC=17348|UniProtKB=O43395	U4/U6 small nuclear ribonucleoprotein Prp3	ISS	12875835	PubMed	PTHR14212:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3
P00013	Cell cycle	P00485	Cdk2	MOUSE|MGI=MGI=1914486|UniProtKB=Q9D0V8	Cyclin-dependent kinase 2-interacting protein	ISS	12477932	PubMed	PTHR15827:SF2	CYCLIN-DEPENDENT KINASE 2-INTERACTING PROTEIN
P04393	Ras Pathway	P04552	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	IDA	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00046	Oxidative stress response	P01126	ATF2	HUMAN|HGNC=784|UniProtKB=P15336	Cyclic AMP-dependent transcription factor ATF-2	TAS	9819389	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	IC	91056091	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00034	Integrin signalling pathway	P00951	Jnk	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IDA	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00045	Notch signaling pathway	P01103	Next	MACMU|Ensembl=ENSMMUG00000018116|UniProtKB=F7FGM9	Delta-like protein	ISS	7697721	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	RAT|RGD=67366|UniProtKB=P50393	Cytosolic phospholipase A2	IEA	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MACMU|Ensembl=ENSMMUG00000001789|UniProtKB=F7GIU0	5-hydroxytryptamine receptor 1A	ISS	12181435	PubMed	PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00021	FGF signaling pathway	P00638	PLCgamma	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	TAS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	PANTR|Ensembl=ENSPTRG00000014418|UniProtKB=H2QLS0	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00021	FGF signaling pathway	P00628	JNK1-3	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02723	Adenine and hypoxanthine salvage pathway	P02804	Hypoxanthine phosphoribosyl transferase	BOVIN|Ensembl=ENSBTAG00000014685|UniProtKB=Q3SZ18	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF6	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE
P00048	PI3 kinase pathway	P01199	Galpha	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00012	Cadherin signaling pathway	P00467	alpha-catenin	MONDO|Ensembl=ENSMODG00000015456|UniProtKB=F6S406	Uncharacterized protein	ISS	9362521	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P00005	Angiogenesis	P00220	c-Jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00020	FAS signaling pathway	P00616	Nuclear Lamin	RAT|RGD=1563803|UniProtKB=D3ZLC1	Protein Lmnb2	ISS	11165516	PubMed	PTHR23239:SF152	LAMIN-B2
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00057	Wnt signaling pathway	P01444	Wnt	DROME|FlyBase=FBgn0004360|UniProtKB=P28465	Protein Wnt-2	IDA	8717036	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P04392	P53 pathway feedback loops 1	G04683	Cop-1	PANTR|Ensembl=ENSPTRG00000001711|UniProtKB=H2R8E1	Ring finger and WD repeat domain 2	ISS	15103385	PubMed	PTHR44080:SF1	E3 UBIQUITIN-PROTEIN LIGASE RFWD2
P00009	Axon guidance mediated by netrin	P00366	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	ANOGA|EnsemblGenome=AGAP006027|UniProtKB=Q7PNT0	AGAP006027-PA	IC	12941441	PubMed	PTHR18966:SF270	GLUTAMATE RECEPTOR 1-RELATED
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00570	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	BOVIN|Ensembl=ENSBTAG00000001575|UniProtKB=F1N6C0	Uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF311	CALMODULIN
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00015	Circadian clock system	P00504	Per	BOVIN|Ensembl=ENSBTAG00000003889|UniProtKB=F1MDK3	Uncharacterized protein	ISS	20570170	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	DANRE|ZFIN=ZDB-GENE-070524-2|UniProtKB=B6E506	Dopamine receptor D1	ISS	9700720	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	BOVIN|Ensembl=ENSBTAG00000018114|UniProtKB=Q28043	Activin receptor type-2A	TAS	9395284	PubMed	PTHR23255:SF64	ACTIVIN RECEPTOR TYPE-2A
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04580	TRH Receptor	PANTR|Ensembl=ENSPTRG00000020508|UniProtKB=H2R9Q8	Uncharacterized protein	ISS	7509436	PubMed	PTHR24243:SF115	THYROTROPIN-RELEASING HORMONE RECEPTOR
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95810|UniProtKB=Q9Z2W9	Glutamate receptor 3	ISS	12871085	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	DANRE|ZFIN=ZDB-GENE-051202-2|UniProtKB=Q6ZM67	Uncharacterized protein	ISS	11319238	PubMed	PTHR44391:SF3	SUBFAMILY NOT NAMED
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	RAT|RGD=1304556|UniProtKB=P63259	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00048	PI3 kinase pathway	P01179	PKB	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00045	Notch signaling pathway	P01103	Next	RAT|RGD=3187|UniProtKB=Q07008	Neurogenic locus notch homolog protein 1	IEP	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P05918	p38 MAPK pathway	P06043	ASK1	HUMAN|HGNC=6857|UniProtKB=Q99683	Mitogen-activated protein kinase kinase kinase 5	TAS	8974401	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01456	beta-arrestin	PANTR|Ensembl=ENSPTRG00000013052|UniProtKB=H2QJM8	Uncharacterized protein	ISS	10206946	PubMed	PTHR11792:SF15	S-ARRESTIN
P00009	Axon guidance mediated by netrin	P00363	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00736	CalDAG-GEF	RAT|RGD=3539|UniProtKB=Q9R1K8	RAS guanyl-releasing protein 1	IDA	10835426	PubMed	PTHR23113:SF174	RAS GUANYL-RELEASING PROTEIN 1
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00562	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DICDI|dictyBase=DDB_G0279413|UniProtKB=P05987	cAMP-dependent protein kinase regulatory subunit	IC	91298951	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P02752	Mannose metabolism	P03018	Mannose 1-P guanylyl transferase	MACMU|Ensembl=ENSMMUG00000014584|UniProtKB=F7GRF0	Uncharacterized protein	ISS	11082198	PubMed	PTHR22572:SF15	MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE BETA
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	ISS	14684598	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00018	EGF receptor signaling pathway	P00552	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	GLOVI|Gene=BAC90440|UniProtKB=Q7NHN6	Glutamine synthetase III	ISS			PTHR43785:SF1	TYPE-1 GLUTAMINE SYNTHETASE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	BOVIN|Gene=CACNB1|UniProtKB=Q9MZL7	Voltage-dependent L-type calcium channel subunit beta-1	ISS	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P05918	p38 MAPK pathway	P06039	MSK2	BOVIN|Ensembl=ENSBTAG00000039153|UniProtKB=F1MQE1	Ribosomal protein S6 kinase	ISS	9792677	PubMed	PTHR24351:SF41	RIBOSOMAL PROTEIN S6 KINASE ALPHA-4
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00011	Blood coagulation	P00407	PZ	MOUSE|MGI=MGI=1860488|UniProtKB=Q9CQW3	Vitamin K-dependent protein Z	ISS			PTHR24278:SF20	VITAMIN K-DEPENDENT PROTEIN Z
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IDA	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	P01465	Ggamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00005	Angiogenesis	P00193	SOS-1	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05913	Enkephalin release	P05974	G-Protein (i)	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00060	Ubiquitin proteasome pathway	P01491	E2	PHYPA|Gene=PHYPADRAFT_164116|UniProtKB=A9SCD7	Predicted protein	ISS			PTHR24068:SF55	UBIQUITIN-CONJUGATING ENZYME E2 11-RELATED
P04393	Ras Pathway	P04578	Rho	PANTR|Ensembl=ENSPTRG00000014922|UniProtKB=H2QML4	Uncharacterized protein	ISS	12039949	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00054	Toll receptor signaling pathway	P01375	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00034	Integrin signalling pathway	P00951	Jnk	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02750	Lipoate_biosynthesis	P03003	Lipoyl-protein ligase	MOUSE|MGI=MGI=1914414|UniProtKB=Q9D009	Putative lipoyltransferase 2, mitochondrial	ISS			PTHR10993:SF7	LIPOYLTRANSFERASE 2, MITOCHONDRIAL-RELATED
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	BOVIN|Ensembl=ENSBTAG00000034854|UniProtKB=F1N246	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	TAKRU|Ensembl=ENSTRUG00000015938|UniProtKB=H2UUX5	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00034	Integrin signalling pathway	P00944	Actin	CAEEL|WormBase=WBGene00000067|UniProtKB=O45815	ACTin	ISS	3487386	PubMed	PTHR11937:SF352	ACTIN
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00811	Arp2/3 complex	RAT|RGD=2155|UniProtKB=O88656	Actin-related protein 2/3 complex subunit 1B	TAS	9618202	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00015	Circadian clock system	P00505	Cry	HUMAN|HGNC=2385|UniProtKB=Q49AN0	Cryptochrome-2	IEP	14507900	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DICDI|dictyBase=DDB_G0269234|UniProtKB=P07830	Major actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00059	p53 pathway	P04630	PP2A	BOVIN|Ensembl=ENSBTAG00000009245|UniProtKB=Q0P594	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	HUMAN|HGNC=132|UniProtKB=P60709	Actin, cytoplasmic 1	IC	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P05912	Dopamine receptor mediated signaling pathway	P05963	MAO	MOUSE|MGI=MGI=96915|UniProtKB=Q64133	Amine oxidase [flavin-containing] A	ISS	90344230	PubMed	PTHR43563:SF3	AMINE OXIDASE  FLAVIN-CONTAINING  A
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	88241036	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DICDI|dictyBase=DDB_G0277143|UniProtKB=P36408	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00052	TGF-beta signaling pathway	P01279	Smurfs	DROME|FlyBase=FBgn0029006|UniProtKB=Q9V853	E3 ubiquitin-protein ligase Smurf1	TAS	http://flybase.org/reports/FBgn0029006.html	Website	PTHR11254:SF395	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	ISS	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01177	P110ACT	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02723	Adenine and hypoxanthine salvage pathway	P02813	Inosine phosphorylase	MOUSE|MGI=MGI=3712328|UniProtKB=Q9D8C9	Purine nucleoside phosphorylase	ISS	7903568	PubMed	PTHR11904:SF12	PURINE NUCLEOSIDE PHOSPHORYLASE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	CHICK|Ensembl=ENSGALG00000014975|UniProtKB=F1NTE9	Uncharacterized protein	ISS	15328036	PubMed	PTHR43893:SF8	D 1B  DOPAMINE RECEPTOR
P00048	PI3 kinase pathway	P01178	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8316835	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00012	Cadherin signaling pathway	P00475	Frizzled	MOUSE|MGI=MGI=1196625|UniProtKB=O70421	Frizzled-1	IDA	11212302	PubMed	PTHR11309:SF81	FRIZZLED-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00059	p53 pathway	G01566	TSP1	PANTR|Ensembl=ENSPTRG00000006907|UniProtKB=H2Q953	Thrombospondin 1	ISS	7521539	PubMed	PTHR10199:SF78	THROMBOSPONDIN-1
P00053	T cell activation	P01300	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00046	Oxidative stress response	P01131	MKP5	PANTR|Ensembl=ENSPTRG00000038773|UniProtKB=H2RGU9	Dual specificity phosphatase 3	ISS			PTHR10159:SF485	DUAL SPECIFICITY PROTEIN PHOSPHATASE 3
P05912	Dopamine receptor mediated signaling pathway	P05957	K+ channel	MOUSE|MGI=MGI=1100509|UniProtKB=O35111	Potassium channel subfamily K member 3	ISS	11875121	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	IC	14684598	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IDA	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00021	FGF signaling pathway	P00640	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	SCLS1|Gene=SS1G_13726|UniProtKB=A7F7Z6	Uncharacterized protein	ISS			PTHR24072:SF192	CDC42 HOMOLOG
P00029	Huntington disease	P00771	Sin3A	MACMU|Ensembl=ENSMMUG00000009281|UniProtKB=F7H3V1	Paired amphipathic helix protein Sin3a	ISS	10441327	PubMed	PTHR12346:SF2	PAIRED AMPHIPATHIC HELIX PROTEIN SIN3A
P00005	Angiogenesis	P00227	PLA2	DANRE|ZFIN=ZDB-GENE-990415-45|UniProtKB=P50392	Cytosolic phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00054	Toll receptor signaling pathway	P01375	JNK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00019	Endothelin signaling pathway	P00566	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00774	Dynein complex	MOUSE|MGI=MGI=107738|UniProtKB=Q6PDL0	Cytoplasmic dynein 1 light intermediate chain 2	ISS	9454836	PubMed	PTHR12688:SF1	CYTOPLASMIC DYNEIN 1 LIGHT INTERMEDIATE CHAIN 2
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	SULSO|EnsemblGenome=SSO1268|UniProtKB=Q97YQ6	Glutamine-fructose-6-phosphate transaminase (Isomerizing) (GlmS-2)	ISS			PTHR10937:SF0	GH12731P-RELATED
P00010	B cell activation	P00383	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IDA	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	TAS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00056	VEGF signaling pathway	P01422	eNOS	MOUSE|MGI=MGI=97362|UniProtKB=P70313	Nitric oxide synthase, endothelial	ISS	22462730	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00034	Integrin signalling pathway	P00925	MEK	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00009	Axon guidance mediated by netrin	P00357	Netrin	PANTR|Ensembl=ENSPTRG00000001023|UniProtKB=H2R8U5	Uncharacterized protein	ISS			PTHR10574:SF28	NETRIN-G1
P00005	Angiogenesis	P00238	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	MOUSE|MGI=MGI=88276|UniProtKB=Q02248	Catenin beta-1	TAS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P05916	Opioid prodynorphin pathway	P06002	G-protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P02758	Ornithine degradation	P03055	Aminobutyraldehyde dehydrogenase	ECOLI|EcoGene=EG12387|UniProtKB=P37339	L-2-hydroxyglutarate oxidase LhgO	ISS			PTHR43104:SF2	L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00057	Wnt signaling pathway	P01443	Phospholipase C	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IDA	9860142	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00014	Cholesterol biosynthesis	P00499	Farnesyl-diphosphate farnesyltransferase	ARATH|TAIR=AT4G34640|UniProtKB=P53799	Squalene synthase	ISS			PTHR11626:SF2	SQUALENE SYNTHASE
P00054	Toll receptor signaling pathway	P01368	MKK2	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CHICK|Gene=JUN|UniProtKB=P18870	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IDA	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00015	Circadian clock system	P00504	Per	CHICK|Ensembl=ENSGALG00000000573|UniProtKB=E1C8E2	Uncharacterized protein	ISS			PTHR11269:SF13	PERIOD CIRCADIAN PROTEIN HOMOLOG 3
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00053	T cell activation	P01314	nck	MONDO|Ensembl=ENSMODG00000018540|UniProtKB=F7GD33	Uncharacterized protein	ISS	12874226	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	RCA	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Ensembl=ENSPTRG00000013825|UniProtKB=H2RAK4	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MONDO|Ensembl=ENSMODG00000014313|UniProtKB=F7BTW0	Ribosomal protein S6 kinase	ISS	11861821	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	PANTR|Ensembl=ENSPTRG00000014187|UniProtKB=H2R714	Protein-serine/threonine kinase	ISS	10852916	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P00053	T cell activation	P01307	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00034	Integrin signalling pathway	P00925	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00056	VEGF signaling pathway	P01407	Erk	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DANRE|ZFIN=ZDB-GENE-041001-104|UniProtKB=Q5TZD4	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04393	Ras Pathway	P04545	Sec5	DANRE|ZFIN=ZDB-GENE-040426-1160|UniProtKB=Q5RGD7	Exocyst complex component 2	ISS			PTHR13043:SF1	EXOCYST COMPLEX COMPONENT 2
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	ARATH|TAIR=AT2G23080|UniProtKB=O64817	Probable casein kinase II subunit alpha	IDA	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01411	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	87226391	PubMed	PTHR24070:SF385	GTPASE HRAS
P06959	CCKR signaling map	P07090	MAPK8-10	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	RCA	9003778	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04393	Ras Pathway	P04547	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	ECOLI|EcoGene=EG10110|UniProtKB=P17445	NAD/NADP-dependent betaine aldehyde dehydrogenase	IC			PTHR11699:SF115	NAD/NADP-DEPENDENT BETAINE ALDEHYDE DEHYDROGENASE
P05915	Opioid proenkephalin pathway	P05985	Mu or Delta receptor	RAT|RGD=3233|UniProtKB=P33533	Delta-type opioid receptor	RCA	12093103	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IDA	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00035	Interferon-gamma signaling pathway	P00960	PTP	CHICK|Ensembl=ENSGALG00000004821|UniProtKB=Q90687	Tyrosine-protein phosphatase non-receptor type 11	TAS	14525967	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01162	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	MACMU|Ensembl=ENSMMUG00000021423|UniProtKB=F7EEZ1	Phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06959	CCKR signaling map	P07163	SRC @Galphaq	HUMAN|HGNC=11283|UniProtKB=P12931	Proto-oncogene tyrosine-protein kinase Src	RCA	10400698	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00034	Integrin signalling pathway	P00947	Laminin	HUMAN|HGNC=13658|UniProtKB=Q9HB63	Netrin-4	IPI	2538453	PubMed	PTHR10574:SF282	NETRIN-4
P00038	JAK/STAT signaling pathway	P01027	STAT	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	ISS	14984365	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00036	Interleukin signaling pathway	P00981	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00137	Tip60	HUMAN|HGNC=17016|UniProtKB=O95251	Histone acetyltransferase KAT7	IDA			PTHR10615:SF102	HISTONE ACETYLTRANSFERASE KAT7
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000025373|UniProtKB=F6ZZG9	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	RAT|RGD=2830|UniProtKB=P31390	Histamine H1 receptor	IDA			PTHR43914:SF2	HISTAMINE H1 RECEPTOR
P00036	Interleukin signaling pathway	P00986	eNOS	MONDO|Ensembl=ENSMODG00000003903|UniProtKB=F6S3S1	Nitric oxide synthase	ISS	9837777	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	9298898	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IGI	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	MACMU|Ensembl=ENSMMUG00000000983|UniProtKB=F6SYL4	Fructose-bisphosphate aldolase	ISS	4812352	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00021	FGF signaling pathway	P00633	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00056	VEGF signaling pathway	P01408	Akt/PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00038	JAK/STAT signaling pathway	P01027	STAT	TAKRU|Ensembl=ENSTRUG00000000102|UniProtKB=H2RJA9	Signal transducer and activator of transcription	ISS	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P05918	p38 MAPK pathway	P06043	ASK1	MOUSE|MGI=MGI=1346876|UniProtKB=O35099	Mitogen-activated protein kinase kinase kinase 5	TAS	12968034	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	BOVIN|Ensembl=ENSBTAG00000011579|UniProtKB=F1N5C5	Muscarinic acetylcholine receptor	ISS	8100450	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	MONDO|Ensembl=ENSMODG00000014177|UniProtKB=F6U7A6	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MOUSE|MGI=MGI=1354694|UniProtKB=Q9JL25	Regulator of G-protein signaling 1	IDA	8756726	PubMed	PTHR10845:SF34	REGULATOR OF G-PROTEIN SIGNALING 1
P00006	Apoptosis signaling pathway	P00269	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01275	P38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00020	FAS signaling pathway	P00620	CytochromeC	CANLF|Ensembl=ENSCAFG00000001529|UniProtKB=E2REM0	Uncharacterized protein	ISS	15163634	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TRIVA|Gene=TVAG_337240|UniProtKB=P90623	Actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00015	Circadian clock system	P00502	Casein kinase I	BOVIN|Ensembl=ENSBTAG00000019986|UniProtKB=P35508	Casein kinase I isoform delta	ISS	11437445	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00057	Wnt signaling pathway	P01451	Galpha	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	IDA	8457205	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00632	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2521|UniProtKB=P19020	D(3) dopamine receptor	IDA	2039532	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IDA	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04398	p53 pathway feedback loops 2	P04665	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00047	PDGF signaling pathway	P01151	PKB	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	SCHMA|EnsemblGenome=Smp_085540|UniProtKB=G4M0G4	Myosin heavy chain, putative	IC			PTHR13140:SF555	MYOSIN HEAVY CHAIN, MUSCLE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00005	Angiogenesis	P00219	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS			PTHR24356:SF240	PROTEIN KINASE C
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Gene=PCDHB12|UniProtKB=Q5DRD7	Protocadherin beta-12	ISS	8120095	PubMed	PTHR24028:SF228	PROTOCADHERIN BETA-12
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	HUMAN|HGNC=240|UniProtKB=O60503	Adenylate cyclase type 9	ISS	2491850	PubMed	PTHR11920:SF319	ADENYLATE CYCLASE TYPE 9
P04398	p53 pathway feedback loops 2	P04665	AKT	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	12655147	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04392	P53 pathway feedback loops 1	P04539	p53	DANRE|ZFIN=ZDB-GENE-030819-1|UniProtKB=E9QG65	Uncharacterized protein	TAS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00009	Axon guidance mediated by netrin	P00363	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00025	Hedgehog signaling pathway	P00697	Sap18	RAT|RGD=1310388|UniProtKB=G3V7F6	Protein RGD1561590	ISS	11960000	PubMed	PTHR13082:SF0	HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18
P02774	Salvage pyrimidine deoxyribonucleotides	P03148	Thymidine phosphorylase	METAC|EnsemblGenome=MA_3242|UniProtKB=Q8TL01	AMP phosphorylase	ISS	12125824	PubMed	PTHR10515:SF0	THYMIDINE PHOSPHORYLASE
P06959	CCKR signaling map	P07079	p38MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	RCA	12239223	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00059	p53 pathway	P04623	CBP	HUMAN|HGNC=3373|UniProtKB=Q09472	Histone acetyltransferase p300	IDA	10769018	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00018	EGF receptor signaling pathway	P00543	ERK1-2	ORYSJ|EnsemblGenome=OS03G0285800|UniProtKB=Q10N20	Mitogen-activated protein kinase 5	ISS			PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	DROME|FlyBase=FBgn0010399|UniProtKB=Q24418	Glutamate [NMDA] receptor subunit 1	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00012	Cadherin signaling pathway	P00462	Casein kinase II	IXOSC|EnsemblGenome=ISCW014459|UniProtKB=B7QIS2	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02917	Ribonucleoside triphosphate Reductase	METAC|EnsemblGenome=MA_0072|UniProtKB=Q8TUJ5	Anaerobic ribonucleoside-triphosphate reductase	ISS			PTHR21075:SF0	ANAEROBIC RIBONUCLEOSIDE-TRIPHOSPHATE REDUCTASE
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00018	EGF receptor signaling pathway	P00555	MKK4,7	MONDO|Ensembl=ENSMODG00000008266|UniProtKB=F6Z879	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P02786	Vitamin B6 biosynthesis	P03225	1-Deoxyxylulose-5-phosphate synthase	ARATH|TAIR=AT3G21500|UniProtKB=F4IXL8	1-deoxy-D-xylulose 5-phosphate synthase 1	ISS			PTHR43322:SF5	1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE 1-RELATED
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	BOVIN|Ensembl=ENSBTAG00000047202|UniProtKB=G3N3K3	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00015	Circadian clock system	G01501	cry	BOVIN|Ensembl=ENSBTAG00000021223|UniProtKB=F1N0J9	Uncharacterized protein	ISS	10428031	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P05913	Enkephalin release	P05974	G-Protein (i)	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04398	p53 pathway feedback loops 2	P04665	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01275	P38	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	4506785	gi	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	BOVIN|Gene=SHMT1|UniProtKB=Q5E9P9	Serine hydroxymethyltransferase, cytosolic	ISS			PTHR11680:SF21	SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05917	Opioid proopiomelanocortin pathway	P06011	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00029	Huntington disease	P00780	Microtubule	RAT|RGD=735101|UniProtKB=Q6P9T8	Tubulin beta-4B chain	ISS	9454836	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04371	5-Hydroxytryptamine biosynthesis	P04400	Aromatic L-amino acid decarboxylase	MOUSE|MGI=MGI=94876|UniProtKB=O88533	Aromatic-L-amino-acid decarboxylase	IEA	107930	OMIM	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00057	Wnt signaling pathway	P01429	Axin	RAT|RGD=620859|UniProtKB=O70239	Axin-1	IDA	12356903	PubMed	PTHR10845:SF11	AXIN-1
P00019	Endothelin signaling pathway	P00591	PLCbeta	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	PANTR|Ensembl=ENSPTRG00000018398|UniProtKB=H2QTD1	Glycoprotein hormones alpha chain	ISS	89325834	PubMed	PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00898	FKHR	RAT|RGD=1309196|UniProtKB=D3ZBQ1	Forkhead box O3a (Predicted)	ISS	14775847	gi	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	CANLF|Ensembl=ENSCAFG00000012353|UniProtKB=E2RSE6	Uncharacterized protein	ISS	10956649	PubMed	PTHR42884:SF1	FURIN
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CAEEL|WormBase=WBGene00000066|UniProtKB=P10986	Actin-4	ISS	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	ARATH|TAIR=AT4G38530|UniProtKB=Q56W08	Phosphoinositide phospholipase C 3	ISS			PTHR10336:SF105	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE
P05913	Enkephalin release	G06045	preproenkephalin	PANTR|Ensembl=ENSPTRG00000020270|UniProtKB=H2QW70	Proenkephalin	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00018	EGF receptor signaling pathway	P00564	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	IPI	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IGI	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01205	NOS	MACMU|Ensembl=ENSMMUG00000020437|UniProtKB=F6WEB2	Nitric oxide synthase	ISS	9837777	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P04393	Ras Pathway	P04546	GSK3	MACMU|Ensembl=ENSMMUG00000014597|UniProtKB=F6VAQ6	Glycogen synthase kinase-3 alpha	ISS	21361340	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P04393	Ras Pathway	P04543	MEKK1/4	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS	602425	OMIM	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P04398	p53 pathway feedback loops 2	P04665	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00020	FAS signaling pathway	P00618	CAD	DANRE|ZFIN=ZDB-GENE-030826-4|UniProtKB=Q1L9C6	Uncharacterized protein	TAS	10739646	PubMed	PTHR13067:SF2	DNAATION FACTOR-RELATED PROTEIN 4
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IGI	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00006	Apoptosis signaling pathway	P00310	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	CANLF|Ensembl=ENSCAFG00000023650|UniProtKB=E2QWU0	Actin-related protein 2/3 complex subunit 4	ISS	5031595	gi	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00021	FGF signaling pathway	P00627	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9441|UniProtKB=P51817	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00021	FGF signaling pathway	P00647	SHP2	MOUSE|MGI=MGI=99511|UniProtKB=P35235	Tyrosine-protein phosphatase non-receptor type 11	IGI	14534538	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000014828|UniProtKB=F1N1E0	Uncharacterized protein	ISS	14624853	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00019	Endothelin signaling pathway	P00578	eNOS	BOVIN|Gene=NOS3|UniProtKB=P29473	Nitric oxide synthase, endothelial	IGI	10435050	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P04398	p53 pathway feedback loops 2	G04714	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00053	T cell activation	P01306	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=7604|UniProtKB=Q9NQX4	Unconventional myosin-Vc	IC			PTHR13140:SF313	UNCONVENTIONAL MYOSIN-VC
P02748	Isoleucine biosynthesis	P02997	Acetolactate synthase	THEMA|EnsemblGenome=TM_0548|UniProtKB=Q9WZ18	Acetolactate synthase	ISS			PTHR18968:SF116	ACETOLACTATE SYNTHASE ISOZYME 3 LARGE SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00038	JAK/STAT signaling pathway	P01027	STAT	CANLF|Ensembl=ENSCAFG00000000163|UniProtKB=F1PAY3	Signal transducer and activator of transcription	ISS	94367369	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00053	T cell activation	P01332	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01275	P38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	TAS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	CANLF|Ensembl=ENSCAFG00000001315|UniProtKB=E2R9S7	Uncharacterized protein	ISS	9362521	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P04393	Ras Pathway	P04557	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00009	Axon guidance mediated by netrin	P00359	NFAT	MOUSE|MGI=MGI=1920431|UniProtKB=Q8K120	Nuclear factor of activated T-cells, cytoplasmic 4	IDA	9462517	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00006	Apoptosis signaling pathway	P00270	Bcl-2	CHICK|Ensembl=ENSGALG00000012885|UniProtKB=Q00709	Apoptosis regulator Bcl-2	IDA	1508712	PubMed	PTHR11256:SF11	APOPTOSIS REGULATOR BCL-2
P00057	Wnt signaling pathway	P01451	Galpha	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	IXOSC|EnsemblGenome=ISCW009711|UniProtKB=B7Q3T6	THO complex subunit, putative	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	2837282	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=1306801|UniProtKB=F8VPK8	Protein Pcdh9	ISS	8120095	PubMed	PTHR43912:SF5	PROTOCADHERIN-9
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	MACMU|Ensembl=ENSMMUG00000011852|UniProtKB=F7H4T8	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MACMU|Ensembl=ENSMMUG00000012054|UniProtKB=F6TII3	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00054	Toll receptor signaling pathway	P01345	IKKalpha	BOVIN|Ensembl=ENSBTAG00000007591|UniProtKB=Q95KV1	Inhibitor of nuclear factor kappa-B kinase subunit alpha	ISS	14499113	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P05916	Opioid prodynorphin pathway	P06000	vasopressin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00021	FGF signaling pathway	P00628	JNK1-3	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00011	Blood coagulation	P00411	PAI-1	BOVIN|Ensembl=ENSBTAG00000014465|UniProtKB=P13909	Plasminogen activator inhibitor 1	ISS	10692390	PubMed	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04395	Vasopressin synthesis	P04589	Signal Peptidase	DROME|FlyBase=FBgn0039172|UniProtKB=Q9VCA9	Signal peptidase complex subunit 3	IC	2092035	PubMed	PTHR12804:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 3
P00018	EGF receptor signaling pathway	P00560	Raf-1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IGI	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05915	Opioid proenkephalin pathway	P05994	G-protein	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	ANOGA|EnsemblGenome=AGAP005911|UniProtKB=Q7Q6D4	AGAP005911-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00034	Integrin signalling pathway	P00931	Integrin beta	MACMU|Ensembl=ENSMMUG00000006898|UniProtKB=F7F3K9	Integrin beta	ISS	3487386	PubMed	PTHR10082:SF9	INTEGRIN BETA-8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	IDA	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00045	Notch signaling pathway	G01541	E(spl)-C genes	HUMAN|HGNC=19764|UniProtKB=Q5TA89	Transcription factor HES-5	TAS	14973298	PubMed	PTHR10985:SF104	TRANSCRIPTION FACTOR HES-5
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	MONDO|Ensembl=ENSMODG00000025146|UniProtKB=F7CLC0	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF311	CALMODULIN
P00047	PDGF signaling pathway	P01164	PDK1/2	YEAST|SGD=S000002874|UniProtKB=Q03306	Serine/threonine-protein kinase PKH3	ISS			PTHR24356:SF238	SERINE/THREONINE-PROTEIN KINASE PKH3
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00021	FGF signaling pathway	P00647	SHP2	CANLF|Ensembl=ENSCAFG00000008894|UniProtKB=F1Q3J6	Tyrosine-protein phosphatase non-receptor type	ISS	95163101	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00021	FGF signaling pathway	P00638	PLCgamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00049	Parkinson disease	P01218	alpha-Synuclein	MOUSE|MGI=MGI=1277151|UniProtKB=O55042	Alpha-synuclein	TAS	9278044	PubMed	PTHR13820:SF5	ALPHA-SYNUCLEIN
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	PANTR|Ensembl=ENSPTRG00000031262|UniProtKB=H2RAB4	Uncharacterized protein	ISS	11861492	PubMed	PTHR43893:SF8	D 1B  DOPAMINE RECEPTOR
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	BRAFL|Gene=BRAFLDRAFT_220697|UniProtKB=C3ZSF0	Putative uncharacterized protein	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	14744463	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IDA	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02770	Pyridoxal phosphate salvage pathway	P03123	Pyridoxine-5-phosphate oxidase	CANLF|Ensembl=ENSCAFG00000016814|UniProtKB=E2QTE2	Uncharacterized protein	ISS	9601034	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00004	Alzheimer disease-presenilin pathway	P00131	HAC1	MONDO|Ensembl=ENSMODG00000018582|UniProtKB=F7FDA8	Uncharacterized protein	ISS			PTHR44028:SF1	TRIPARTITE MOTIF-CONTAINING PROTEIN 3
P04393	Ras Pathway	P04556	Raf	XENTR|Xenbase=XB-GENE-1014202|UniProtKB=F6V946	Uncharacterized protein (Fragment)	ISS	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00053	T cell activation	P01330	IKK	HUMAN|HGNC=5960|UniProtKB=O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	IGI	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00021	FGF signaling pathway	P00624	14-3-3	DAPPU|EnsemblGenome=DAPPUDRAFT_326737|UniProtKB=E9H8M4	Putative uncharacterized protein	ISS	97302963	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00057	Wnt signaling pathway	P01465	Ggamma	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	RAT|RGD=2738|UniProtKB=Q00960	Glutamate receptor ionotropic, NMDA 2B	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00022	General transcription by RNA polymerase I	P00655	UBF1	MACMU|Ensembl=ENSMMUG00000010217|UniProtKB=F6SAH5	Uncharacterized protein	ISS			PTHR13711:SF227	UPSTREAM-BINDING FACTOR 1-LIKE PROTEIN 1-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	BOVIN|Ensembl=ENSBTAG00000005800|UniProtKB=F1N3G8	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00005	Angiogenesis	P00243	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00006	Apoptosis signaling pathway	P00321	HSP70	ORNAN|Ensembl=ENSOANG00000013291|UniProtKB=F6S4U9	Uncharacterized protein	ISS	10934466	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P04398	p53 pathway feedback loops 2	P04649	Myc	MOUSE|MGI=MGI=97250|UniProtKB=P01108	Myc proto-oncogene protein	TAS	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05915	Opioid proenkephalin pathway	P05994	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-040426-2280|UniProtKB=Q6P025	Gnb3 protein	ISS			PTHR19850:SF35	GNB3 PROTEIN
P04393	Ras Pathway	P04567	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P02774	Salvage pyrimidine deoxyribonucleotides	P03145	Uracil phosphorylase	ECOLI|EcoGene=EG10219|UniProtKB=P07650	Thymidine phosphorylase	ISS	11677608	PubMed	PTHR10515:SF0	THYMIDINE PHOSPHORYLASE
P00022	General transcription by RNA polymerase I	P00649	TAF-IC	ARATH|TAIR=AT3G02160|UniProtKB=Q9S7R9	At3g02160	ISS			PTHR12321:SF53	BROMODOMAIN TRANSCRIPTION FACTOR
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CHICK|Ensembl=ENSGALG00000028612|UniProtKB=F1P3X1	Uncharacterized protein	IC	89264452	PubMed	PTHR13140:SF728	MYOSIN HEAVY CHAIN, SKELETAL MUSCLE, ADULT
P00017	DNA replication	P00527	Histones	BOVIN|Ensembl=ENSBTAG00000024561|UniProtKB=Q5E9F8	Histone H3.3	ISS	12413958	PubMed	PTHR11426:SF179	HISTONE H3.3
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01142	p90RSK	MACMU|Ensembl=ENSMMUG00000019305|UniProtKB=F6S3T8	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00898	FKHR	MACMU|Ensembl=ENSMMUG00000020369|UniProtKB=F6UMX8	Uncharacterized protein	ISS	12048180	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00018	EGF receptor signaling pathway	P00558	SOS	DICDI|dictyBase=DDB_G0269252|UniProtKB=Q8IS18	Ras guanine nucleotide exchange factor E	ISS			PTHR23113:SF209	RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR E
P00059	p53 pathway	P04623	CBP	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	IDA	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P06664	Gonadotropin-releasing hormone receptor pathway	P06841	gnaq/11	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	RCA	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	CHICK|Ensembl=ENSGALG00000010273|UniProtKB=P48463	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	1662645	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	IC	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00983	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	XENTR|Xenbase=XB-GENE-488460|UniProtKB=Q6DIY4	TATA box-binding protein-like protein 1	ISS	600075	OMIM	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00018	EGF receptor signaling pathway	P00564	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12874273	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P06959	CCKR signaling map	P07166	MAPK1	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	RCA	9324163	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MOUSE|MGI=MGI=1342290|UniProtKB=Q9WUT3	Ribosomal protein S6 kinase alpha-2	TAS	1922062	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IDA	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00256	PLC-gamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	SCHPO|PomBase=SPBC32H8.12c|UniProtKB=P10989	Actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	XENTR|Xenbase=XB-GENE-480347|UniProtKB=Q6P640	Actin, alpha cardiac muscle 1	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=2683547|UniProtKB=Q4KWH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1	ISS	7822322	PubMed	PTHR10336:SF51	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-1
P00005	Angiogenesis	P00249	PAK	MOUSE|MGI=MGI=1339656|UniProtKB=Q61036	Serine/threonine-protein kinase PAK 3	ISS	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00059	p53 pathway	P04609	PI3K	ANOGA|EnsemblGenome=AGAP011036|UniProtKB=A0NBA9	AGAP011036-PA (Fragment)	ISS	7937853	PubMed	PTHR10048:SF64	LD28067P
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	TAS			PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=4595|UniProtKB=Q14832	Metabotropic glutamate receptor 3	IDA	12351712	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00020	FAS signaling pathway	P00615	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05730	Endogenous cannabinoid signaling	P05751	Galpha	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	9395335	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	IC	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	TAS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9062|UniProtKB=Q9BRC7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	10934033	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00018	EGF receptor signaling pathway	P00558	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00049	Parkinson disease	P01227	20S proteasome	ENTHI|EnsemblGenome=EHI_004760|UniProtKB=C4LUL4	Proteasome subunit alpha type	TAS	12859888	PubMed	PTHR11599:SF14	PROTEASOME SUBUNIT ALPHA TYPE-5
P00053	T cell activation	P01333	cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	BOVIN|Ensembl=ENSBTAG00000011723|UniProtKB=E1BKL6	Uncharacterized protein	ISS	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00254	GTPase	CHICK|Ensembl=ENSGALG00000003806|UniProtKB=O93467	GTP-binding protein	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	DEIRA|EnsemblGenome=DR_2177|UniProtKB=Q9RSE7	Cytidine deaminase	ISS			PTHR11644:SF2	CYTIDINE DEAMINASE
P00029	Huntington disease	P00777	CBP	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00009	Axon guidance mediated by netrin	P00357	Netrin	CANLF|Ensembl=ENSCAFG00000019366|UniProtKB=E2R3Q6	Uncharacterized protein	ISS			PTHR10574:SF292	NETRIN-3
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00056	VEGF signaling pathway	P01408	Akt/PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00049	Parkinson disease	P01238	14-3-3	TAKRU|Ensembl=ENSTRUG00000004697|UniProtKB=H2SFG7	Uncharacterized protein	ISS	91108808	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IDA	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02759	Pyridoxal-5-phosphate biosynthesis	P03058	Phosphohydroxythreonine aminotransferase	ARATH|TAIR=AT2G17630|UniProtKB=Q9SHP0	Phosphoserine aminotransferase 2, chloroplastic	ISS			PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P00021	FGF signaling pathway	P00640	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00302	ATF	BOVIN|Ensembl=ENSBTAG00000002295|UniProtKB=F1N177	Uncharacterized protein	ISS	10207617	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P02788	Xanthine and guanine salvage pathway	P03250	Guanosine phosphorylase	SCHPO|PomBase=SPAC1805.16c|UniProtKB=Q9UTG1	Putative purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00021	FGF signaling pathway	P00648	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IGI	2837282	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00030	Hypoxia response via HIF activation	P00823	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P02756	N-acetylglucosamine metabolism	P03039	Glucosamine-1-phosphate acetyltransferase	AQUAE|EnsemblGenome=aq_607|UniProtKB=O66863	Bifunctional protein GlmU	ISS			PTHR43584:SF3	BIFUNCTIONAL PROTEIN GLMU
P00001	Adrenaline and noradrenaline biosynthesis	P00068	amine translocator	BOVIN|Ensembl=ENSBTAG00000031340|UniProtKB=A1A4L2	Transporter	ISS	12719981	PubMed	PTHR11616:SF44	SODIUM- AND CHLORIDE-DEPENDENT TRANSPORTER XTRP3
P00034	Integrin signalling pathway	P00912	Arp2/3	HUMAN|HGNC=704|UniProtKB=O15143	Actin-related protein 2/3 complex subunit 1B	IPI	12932731	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00019	Endothelin signaling pathway	P00590	IP3 R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	IGI	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	MOUSE|MGI=MGI=106684|UniProtKB=Q8R090	Chromaffin granule amine transporter	ISS	12135927	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	IC	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=621025|UniProtKB=Q62711	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	10934033	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00029	Huntington disease	P00790	beta-Tubulin	MONDO|Ensembl=ENSMODG00000016603|UniProtKB=F6ZCX3	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF112	TUBULIN BETA-1 CHAIN
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=11438|UniProtKB=Q13277	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00052	TGF-beta signaling pathway	P01286	TGFbeta	PANTR|Ensembl=ENSPTRG00000017225|UniProtKB=H2QRG9	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF19	GROWTH/DIFFERENTIATION FACTOR 9
P00047	PDGF signaling pathway	P01160	IP3 receptor	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00012	Cadherin signaling pathway	P00474	Wnt	PANTR|Ensembl=ENSPTRG00000002062|UniProtKB=H2Q194	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P00056	VEGF signaling pathway	P01411	Ras	XENTR|Xenbase=XB-GENE-494548|UniProtKB=F7EC26	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	IC	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	CANLF|Ensembl=ENSCAFG00000010787|UniProtKB=E2R3W6	Uncharacterized protein	ISS	2137198	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00012	Cadherin signaling pathway	P00471	Cadherin	CHICK|Ensembl=ENSGALG00000015132|UniProtKB=P10288	Cadherin-2	IDA	8120095	PubMed	PTHR24027:SF79	CADHERIN-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	RAT|RGD=620966|UniProtKB=Q62925	Mitogen-activated protein kinase kinase kinase 1	IGI	8940199	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P05913	Enkephalin release	P05974	G-Protein (i)	CANLF|Ensembl=ENSCAFG00000028654|UniProtKB=J9P702	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P04393	Ras Pathway	P04560	AP1	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00006	Apoptosis signaling pathway	P00274	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	BOVIN|Ensembl=ENSBTAG00000003512|UniProtKB=E1BPX8	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF358	MYOSIN-7B
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	RAT|RGD=3693|UniProtKB=Q01818	Chromaffin granule amine transporter	ISS	12135927	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00004	Alzheimer disease-presenilin pathway	P00163	Erb-B4 C-terminal fragment	CHICK|Ensembl=ENSGALG00000003126|UniProtKB=F1P258	Receptor protein-tyrosine kinase	ISS	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=2683547|UniProtKB=Q4KWH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1	ISS	15611108	PubMed	PTHR10336:SF51	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-1
P00007	Axon guidance mediated by semaphorins	P00340	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00093	Tip60	BOVIN|Ensembl=ENSBTAG00000005578|UniProtKB=E1BMS5	Histone acetyltransferase	ISS	11441186	PubMed	PTHR10615:SF124	HISTONE ACETYLTRANSFERASE KAT5
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	TAKRU|Ensembl=ENSTRUG00000015213|UniProtKB=H2UPJ1	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF356	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00005	Angiogenesis	P00256	PLC-gamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00019	Endothelin signaling pathway	P00586	Gq	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00036	Interleukin signaling pathway	P00990	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	BOVIN|Ensembl=ENSBTAG00000034693|UniProtKB=P48018	Synaptotagmin-1	RCA	SYT1_BOVIN	SPACC	PTHR10024:SF239	SYNAPTOTAGMIN-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PANTR|Ensembl=ENSPTRG00000002086|UniProtKB=H2Q1A9	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00047	PDGF signaling pathway	P01142	p90RSK	BOVIN|Ensembl=ENSBTAG00000021741|UniProtKB=F1MNR5	Ribosomal protein S6 kinase	ISS	15526037	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00025	Hedgehog signaling pathway	P00682	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	CAEEL|WormBase=WBGene00001620|UniProtKB=Q10901	Excitatory amino acid transporter	IC	94365697	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P00047	PDGF signaling pathway	P01159	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	DANRE|ZFIN=ZDB-GENE-000330-9|UniProtKB=Q90ZE4	Presenilin-2	IDA	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00019	Endothelin signaling pathway	P00589	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PLAF7|EnsemblGenome=PF13_0233|UniProtKB=Q8IDR3	Myosin-A	IC			PTHR13140:SF729	MYOSIN 95E, ISOFORM E
P06587	Nicotine pharmacodynamics pathway	P06590	GNG	ORNAN|Ensembl=ENSOANG00000013961|UniProtKB=F6VPY1	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00047	PDGF signaling pathway	P01153	GSK3	BOVIN|Ensembl=ENSBTAG00000020756|UniProtKB=A6QLB8	GSK3A protein	ISS	183955	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00009	Axon guidance mediated by netrin	P00366	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	10669416	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00047	PDGF signaling pathway	P01174	Rho	RAT|RGD=1307954|UniProtKB=Q5FVG6	Proline-rich protein 5	ISS			PTHR32428:SF4	PROLINE-RICH PROTEIN 5
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	RCA	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04393	Ras Pathway	P04565	MKK4/7	RAT|RGD=1560043|UniProtKB=Q4KSH7	Dual specificity mitogen-activated protein kinase kinase 7	ISS	15039780	PubMed	PTHR24361:SF387	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	BOVIN|Ensembl=ENSBTAG00000012687|UniProtKB=F1MV64	Tyrosine-protein kinase receptor	ISS	249616	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00046	Oxidative stress response	P01129	JNK1/2	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	MOUSE|MGI=MGI=87940|UniProtKB=Q99MK8	Beta-adrenergic receptor kinase 1	RCA			PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00054	Toll receptor signaling pathway	P01358	ERK1	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00049	Parkinson disease	P01238	14-3-3	HUMAN|HGNC=12853|UniProtKB=Q04917	14-3-3 protein eta	IDA	10407019	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00007	Axon guidance mediated by semaphorins	P00329	Sema4D	MACMU|Ensembl=ENSMMUG00000008629|UniProtKB=F6VZ03	Uncharacterized protein	ISS			PTHR11036:SF18	SEMAPHORIN-4D
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00126	Fe65	CANLF|Ensembl=ENSCAFG00000005825|UniProtKB=J9P4C6	Uncharacterized protein	ISS			PTHR14058:SF10	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 3
P00006	Apoptosis signaling pathway	P00289	FAS	MACMU|Gene=FAS|UniProtKB=Q9BDP2	Tumor necrosis factor receptor superfamily member 6	ISS	14585074	PubMed	PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000024633|UniProtKB=F1MBU9	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P05913	Enkephalin release	P05971	CREB	MONDO|Ensembl=ENSMODG00000015970|UniProtKB=F7FD05	Uncharacterized protein	ISS	14604761	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00057	Wnt signaling pathway	P01457	GBeta	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01336	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00053	T cell activation	P01331	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IDA	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	ORNAN|Ensembl=ENSOANG00000009275|UniProtKB=F7EJA3	Uncharacterized protein	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00549	EGF	BOVIN|Gene=BTC|UniProtKB=Q9TTC5	Probetacellulin	ISS			PTHR10740:SF3	PROBETACELLULIN
P00005	Angiogenesis	P00223	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	LEIMA|EnsemblGenome=LmjF.08.1230|UniProtKB=Q4QI42	Beta tubulin	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00047	PDGF signaling pathway	P01160	IP3 receptor	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00590	IP3 R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MONDO|Gene=KRAS|UniProtKB=Q07983	GTPase KRas	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00057	Wnt signaling pathway	P01465	Ggamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00010	B cell activation	P00375	Calmodulin	CAEBR|Gene=CBG01097|UniProtKB=A8WPJ8	Protein CBR-CMD-1	ISS			PTHR23050:SF236	CALMODULIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	IC	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000014976|UniProtKB=H2R892	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CAEBR|Gene=CBG17587|UniProtKB=A8XRA5	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_127488|UniProtKB=C3XYC7	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P02777	Succinate to proprionate conversion	P03161	Methylmalonyl-CoA mutase	MOUSE|MGI=MGI=97239|UniProtKB=P16332	Methylmalonyl-CoA mutase, mitochondrial	ISS			PTHR42710:SF1	METHYLMALONYL-COA MUTASE, MITOCHONDRIAL
P05731	GABA-B receptor II signaling	P05755	Gbeta	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000019277|UniProtKB=H2QUQ1	Uncharacterized protein	ISS	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00049	Parkinson disease	P01211	ERK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	IDA	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00034	Integrin signalling pathway	P00950	Paxillin	CHICK|Gene=PXN|UniProtKB=P49024	Paxillin	IPI	7579684	PubMed	PTHR24216:SF11	PAXILLIN
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	BOVIN|Ensembl=ENSBTAG00000006844|UniProtKB=E1BJ93	Uncharacterized protein	ISS	9039917	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04566	Stat 1/3	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00018	EGF receptor signaling pathway	P00549	EGF	PANTR|Ensembl=ENSPTRG00000016168|UniProtKB=H2QPP5	Uncharacterized protein	ISS			PTHR10740:SF3	PROBETACELLULIN
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IDA	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DICDI|dictyBase=DDB_G0279413|UniProtKB=P05987	cAMP-dependent protein kinase regulatory subunit	IC	91072385	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00021	FGF signaling pathway	P00645	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02738	De novo purine biosynthesis	P02907	dADP kinase	CAEEL|WormBase=WBGene00009119|UniProtKB=Q93576	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01448	CBP	ARATH|TAIR=AT1G79000|UniProtKB=Q9C5X9	Histone acetyltransferase HAC1	ISS	10664585	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00049	Parkinson disease	P01242	Casein kinase I	SCHPO|PomBase=SPAC1805.05|UniProtKB=O74135	Casein kinase I homolog 3	IDA	11437445	PubMed	PTHR11909:SF155	GILGAMESH, ISOFORM L
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	PANTR|Ensembl=ENSPTRG00000017238|UniProtKB=H2QRH7	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00629	PP2A	MONDO|Ensembl=ENSMODG00000020829|UniProtKB=F6RLB3	Uncharacterized protein (Fragment)	ISS	11994459	PubMed	PTHR10648:SF2	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 65 KDA REGULATORY SUBUNIT A ALPHA ISOFORM
P00015	Circadian clock system	P00506	BMAL1	MACMU|Ensembl=ENSMMUG00000009690|UniProtKB=F6XNT8	Uncharacterized protein	ISS	11163178	PubMed	PTHR23042:SF52	ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 1
P00005	Angiogenesis	P00219	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=11433|UniProtKB=Q16623	Syntaxin-1A	ISS	1321498	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00004	Alzheimer disease-presenilin pathway	P00178	BACE-1 pro-domain	MOUSE|MGI=MGI=1346542|UniProtKB=P56818	Beta-secretase 1	IDA	10956649	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P02756	N-acetylglucosamine metabolism	P03039	Glucosamine-1-phosphate acetyltransferase	DEIRA|EnsemblGenome=DR_0808|UniProtKB=Q9RW61	Bifunctional protein GlmU	ISS			PTHR43584:SF3	BIFUNCTIONAL PROTEIN GLMU
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	RAT|RGD=621353|UniProtKB=P08082	Clathrin light chain B	ISS	9388255	PubMed	PTHR10639:SF2	CLATHRIN LIGHT CHAIN B
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	TAKRU|Ensembl=ENSTRUG00000008289|UniProtKB=H2T7U8	Uncharacterized protein	ISS	15723050	PubMed	PTHR24072:SF129	CDC42L PROTEIN
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00059	p53 pathway	P04615	MTA2	MONDO|Ensembl=ENSMODG00000007730|UniProtKB=F7ECL6	Uncharacterized protein	ISS	11099047	PubMed	PTHR10865:SF4	METASTASIS-ASSOCIATED PROTEIN MTA2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PLAF7|EnsemblGenome=PF11_0147|UniProtKB=Q7KQK7	Mitogen-activated protein kinase	TAS			PTHR24055:SF189	SUBFAMILY NOT NAMED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CAEEL|WormBase=WBGene00022534|UniProtKB=Q9TY08	SYntaXin	IC			PTHR19957:SF83	SYNTAXIN-16
P00034	Integrin signalling pathway	P00925	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9060|UniProtKB=P51178	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	15611108	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	CANLF|Ensembl=ENSCAFG00000006453|UniProtKB=F6X958	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00046	Oxidative stress response	P01121	MKK3/6	HUMAN|HGNC=6843|UniProtKB=P46734	Dual specificity mitogen-activated protein kinase kinase 3	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	PANTR|Ensembl=ENSPTRG00000034379|UniProtKB=H2RDK4	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P04393	Ras Pathway	P04553	PAK	CHICK|Ensembl=ENSGALG00000006426|UniProtKB=E1BS97	Uncharacterized protein	ISS	10644687	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	TAKRU|Ensembl=ENSTRUG00000015213|UniProtKB=H2UPJ1	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF356	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04558	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	8838318	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00059	p53 pathway	P04609	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00054	Toll receptor signaling pathway	P01375	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00249	PAK	CHICK|Ensembl=ENSGALG00000006426|UniProtKB=E1BS97	Uncharacterized protein	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00047	PDGF signaling pathway	P01167	Ets	DANRE|ZFIN=ZDB-GENE-980526-426|UniProtKB=Q9PU61	Fli-1 protein	ISS	15298723	PubMed	PTHR11849:SF161	FRIEND LEUKEMIA INTEGRATION 1 TRANSCRIPTION FACTOR
P00053	T cell activation	P01305	Calmodulin	BRAFL|Gene=BRAFLDRAFT_59748|UniProtKB=C3ZEW2	Putative uncharacterized protein	ISS			PTHR23050:SF263	SUBFAMILY NOT NAMED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	SCHPO|PomBase=SPBC32H8.07|UniProtKB=Q10282	Guanine nucleotide-binding protein subunit beta	IC	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00587	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	HUMAN|HGNC=6008|UniProtKB=P01589	Interleukin-2 receptor subunit alpha	IC	11886175	PubMed	PTHR10573:SF0	INTERLEUKIN-2 RECEPTOR SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	CHICK|Ensembl=ENSGALG00000002447|UniProtKB=E1C7M7	Uncharacterized protein	ISS	1768802	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P04398	p53 pathway feedback loops 2	G04714	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00049	Parkinson disease	P01211	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MOUSE|MGI=MGI=96274|UniProtKB=P28334	5-hydroxytryptamine receptor 1B	ISS	11701344	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P00029	Huntington disease	P00795	BDNF	BOVIN|Ensembl=ENSBTAG00000008134|UniProtKB=Q95106	Brain-derived neurotrophic factor	ISS	11724916	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P02759	Pyridoxal-5-phosphate biosynthesis	P03062	1-Deoxyxylulose-5-phosphate synthase	FUSNN|EnsemblGenome=FN1208|UniProtKB=Q8R639	1-deoxy-D-xylulose-5-phosphate synthase	ISS			PTHR43322:SF6	1-DEOXY-D-XYLULOSE-5-PHOSPHATE SYNTHASE
P00010	B cell activation	P00371	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05913	Enkephalin release	P05974	G-Protein (i)	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00005	Angiogenesis	P00221	JNK1	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00029	Huntington disease	P00766	Htt	CANLF|Ensembl=ENSCAFG00000014682|UniProtKB=F1P7Y7	Uncharacterized protein	ISS	8268927	PubMed	PTHR10170:SF10	HUNTINGTIN
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	MACMU|Ensembl=ENSMMUG00000021442|UniProtKB=F7EAQ8	Muscarinic acetylcholine receptor	ISS	12181435	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00034	Integrin signalling pathway	P00941	Integrin alpha	HUMAN|HGNC=6140|UniProtKB=P13612	Integrin alpha-4	IPI	3487386	PubMed	PTHR23220:SF78	INTEGRIN ALPHA-4
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00845	Cyclooxygenase	RAT|RGD=620349|UniProtKB=P35355	Prostaglandin G/H synthase 2	ISS	14684611	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00047	PDGF signaling pathway	P01143	ERK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	ISS			PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01428	Frizzled	PANTR|Ensembl=ENSPTRG00000004148|UniProtKB=H2Q4I6	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF23	FRIZZLED-4
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01052	AC	MACMU|Ensembl=ENSMMUG00000010380|UniProtKB=F7D9M6	Uncharacterized protein	ISS	9874775	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00004	Alzheimer disease-presenilin pathway	P00160	Nectin 1alpha	MACMU|Ensembl=ENSMMUG00000008274|UniProtKB=F7HBK1	Uncharacterized protein	ISS	12376527	PubMed	PTHR23277:SF69	NECTIN-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	PANTR|Ensembl=ENSPTRG00000003795|UniProtKB=H2Q3X5	Muscarinic acetylcholine receptor	ISS	12181435	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MOUSE|MGI=MGI=87902|UniProtKB=P68134	Actin, alpha skeletal muscle	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_56687|UniProtKB=C3YC50	Putative uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P04396	Vitamin D metabolism and pathway	P04607	FDX	BOVIN|Ensembl=ENSBTAG00000011793|UniProtKB=P00257	Adrenodoxin, mitochondrial	IDA	2969697	PubMed	PTHR23426:SF26	ADRENODOXIN, MITOCHONDRIAL
P00009	Axon guidance mediated by netrin	P00361	Ena	RAT|RGD=1307666|UniProtKB=A0A0G2K6I4	Protein Enah	ISS			PTHR11202:SF1	PROTEIN ENABLED HOMOLOG
P00059	p53 pathway	P04624	Cdc25C	RAT|RGD=621498|UniProtKB=P48965	M-phase inducer phosphatase 1	ISS	12408658	gi	PTHR10828:SF46	M-PHASE INDUCER PHOSPHATASE 1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00059	p53 pathway	G01579	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00019	Endothelin signaling pathway	P00566	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=1310903|UniProtKB=D4A978	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF33	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-3
P00036	Interleukin signaling pathway	P00997	Shc	MOUSE|MGI=MGI=98296|UniProtKB=P98083	SHC-transforming protein 1	IGI	7798194	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95817|UniProtKB=Q8BMF5	Glutamate receptor ionotropic, kainate 4	ISS	12871085	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	MACMU|Ensembl=ENSMMUG00000013047|UniProtKB=F7H808	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06011	AC	MOUSE|MGI=MGI=102891|UniProtKB=P51829	Adenylate cyclase type 7	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00054	Toll receptor signaling pathway	P01358	ERK1	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01451	Galpha	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00049	Parkinson disease	P01211	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00006	Apoptosis signaling pathway	P00318	PKCs	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00034	Integrin signalling pathway	P00910	Grb2	MOUSE|MGI=MGI=1918770|UniProtKB=Q9CX99	GRB2-related adapter protein	ISS	51702266	gi	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P00047	PDGF signaling pathway	P01162	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9060|UniProtKB=P51178	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	7822322	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	IDA	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P05918	p38 MAPK pathway	P06025	SRF	PANTR|Ensembl=ENSPTRG00000018189|UniProtKB=H2QT21	Uncharacterized protein	ISS	8660892	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00019	Endothelin signaling pathway	P00570	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	11035810	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00059	p53 pathway	P04633	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00898	FKHR	MOUSE|MGI=MGI=1890081|UniProtKB=Q9WVH4	Forkhead box protein O3	ISS	12048180	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	XENTR|Xenbase=XB-GENE-975313|UniProtKB=F7CSQ4	Uncharacterized protein	ISS	96032356	PubMed	PTHR11958:SF24	EXCITATORY AMINO ACID TRANSPORTER 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00545	JNK1-3	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	MOUSE|MGI=MGI=96281|UniProtKB=P34968	5-hydroxytryptamine receptor 2C	ISS	8143856	PubMed	PTHR24247:SF32	5-HYDROXYTRYPTAMINE RECEPTOR 2C
P00059	p53 pathway	G01571	FAS	MACMU|Gene=FAS|UniProtKB=Q9BDP2	Tumor necrosis factor receptor superfamily member 6	IGI	14585074	PubMed	PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	ARATH|TAIR=AT1G72710|UniProtKB=Q9CAI5	At1g72710	IDA	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	RCA			PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00565	PKC	CANAL|CGD=CAL0003231|UniProtKB=Q5ANK2	Protein kinase C	IGI	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00056	VEGF signaling pathway	P01407	Erk	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02738	De novo purine biosynthesis	P02902	ADP reductase	STRCO|EnsemblGenome=CAA18341|UniProtKB=O69981	Vitamin B12-dependent ribonucleotide reductase	ISS			PTHR43371:SF1	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00035	Interferon-gamma signaling pathway	P00960	PTP	MACMU|Ensembl=ENSMMUG00000010203|UniProtKB=F6SIN0	Tyrosine-protein phosphatase non-receptor type	ISS	14525967	PubMed	PTHR19134:SF65	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 6
P00037	Ionotropic glutamate receptor pathway	P01020	NSF	YEAST|SGD=S000000284|UniProtKB=P18759	Vesicular-fusion protein SEC18	ISS	2657434	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00029	Huntington disease	P00786	ARF	CANLF|Ensembl=ENSCAFG00000024150|UniProtKB=E2RHL4	Uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00047	PDGF signaling pathway	P01151	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04397	p53 pathway by glucose deprivation	P04641	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00038	JAK/STAT signaling pathway	P01034	Jak	RAT|RGD=2939|UniProtKB=Q62689	Tyrosine-protein kinase JAK2	ISS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00054	Toll receptor signaling pathway	P01360	IKKbeta	PANTR|Ensembl=ENSPTRG00000020202|UniProtKB=H2QW34	Uncharacterized protein	ISS	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00048	PI3 kinase pathway	P01179	PKB	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00564	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	15470041	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00012	Cadherin signaling pathway	P00475	Frizzled	RAT|RGD=71017|UniProtKB=Q9QZH0	Frizzled-4	IDA	8717036	PubMed	PTHR11309:SF23	FRIZZLED-4
P00036	Interleukin signaling pathway	P00971	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12162872	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=2685045|UniProtKB=E9QAN8	Protein Pik3c2b	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00057	Wnt signaling pathway	P01438	PP2A	BRAFL|Gene=BRAFLDRAFT_123893|UniProtKB=C3XQF4	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	CAEEL|WormBase=WBGene00009531|UniProtKB=Q20140	Adenylate kinase isoenzyme 1	ISS			PTHR23359:SF70	ADENYLATE KINASE 1, ISOFORM B
P00021	FGF signaling pathway	P00628	JNK1-3	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05734	Synaptic vesicle trafficking	P05777	Synaptophysin	HUMAN|HGNC=11506|UniProtKB=P08247	Synaptophysin	ISS	313475	OMIM	PTHR10306:SF10	SYNAPTOPHYSIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	CANLF|Ensembl=ENSCAFG00000013778|UniProtKB=F6UQ33	Phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	MONDO|Ensembl=ENSMODG00000015399|UniProtKB=F6T507	Uncharacterized protein	ISS	96032356	PubMed	PTHR11958:SF69	EXCITATORY AMINO ACID TRANSPORTER 3
P00006	Apoptosis signaling pathway	P00308	Mcl1	PANTR|Ensembl=ENSPTRG00000001260|UniProtKB=H2PZX1	Uncharacterized protein	ISS	11877256	PubMed	PTHR11256:SF46	INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN MCL-1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P06664	Gonadotropin-releasing hormone receptor pathway	P06831	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	RCA	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05915	Opioid proenkephalin pathway	P05985	Mu or Delta receptor	MONDO|Ensembl=ENSMODG00000008382|UniProtKB=F7CDR6	Uncharacterized protein (Fragment)	ISS	12093103	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00021	FGF signaling pathway	P00627	ERK1-2	ARATH|TAIR=AT2G43790|UniProtKB=Q39026	Mitogen-activated protein kinase 6	ISS			PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	IC	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05913	Enkephalin release	P05974	G-Protein (i)	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	IC	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	CHICK|Ensembl=ENSGALG00000028612|UniProtKB=F1P3X1	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF728	MYOSIN HEAVY CHAIN, SKELETAL MUSCLE, ADULT
P00047	PDGF signaling pathway	P01148	Grb2	CANLF|Ensembl=ENSCAFG00000003613|UniProtKB=F1P7F6	Uncharacterized protein	ISS			PTHR12156:SF18	GRB2-ASSOCIATED-BINDING PROTEIN 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00048	PI3 kinase pathway	P01185	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00048	PI3 kinase pathway	P01179	PKB	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P06002	G-protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	15860573	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00011	Blood coagulation	P00441	FXIIa	BOVIN|Gene=F12|UniProtKB=P98140	Coagulation factor XII	ISS	1352406	gi	PTHR44246:SF3	COAGULATION FACTOR XII
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=11331|UniProtKB=P30874	Somatostatin receptor type 2	IDA	12441358	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P00021	FGF signaling pathway	P00623	FGF	MOUSE|MGI=MGI=1891346|UniProtKB=Q9ESL9	Fibroblast growth factor 20	ISS	11306498	PubMed	PTHR11486:SF72	FIBROBLAST GROWTH FACTOR 20
P00029	Huntington disease	P00805	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05974	G-Protein (i)	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ORYSJ|EnsemblGenome=OS03G0836000|UniProtKB=Q10AZ4	Actin-3	IC	10974003	PubMed	PTHR11937:SF254	ACTIN-1-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00045	Notch signaling pathway	P01115	Neurotic	XENTR|Xenbase=XB-GENE-954943|UniProtKB=Q6NVP8	Alpha-(1,6)-fucosyltransferase	ISS			PTHR13132:SF29	ALPHA- 1,6 -FUCOSYLTRANSFERASE
P00046	Oxidative stress response	P01132	c-jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02776	Serine glycine biosynthesis	P03159	Phosphoserine phosphatase	ARATH|TAIR=AT1G18640|UniProtKB=O82796	Phosphoserine phosphatase, chloroplastic	ISS			PTHR43344:SF2	PHOSPHOSERINE PHOSPHATASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00006	Apoptosis signaling pathway	P00318	PKCs	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00019	Endothelin signaling pathway	P00586	Gq	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CAEEL|WormBase=WBGene00002188|UniProtKB=H2KZI0	Mitogen-activated protein kinase	ISS			PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01238	14-3-3	RAT|RGD=62002|UniProtKB=P61983	14-3-3 protein gamma	ISS	10407019	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00045	Notch signaling pathway	P01114	Ntm	RAT|RGD=620761|UniProtKB=Q9R172	Neurogenic locus notch homolog protein 3	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	HUMAN|HGNC=9996|UniProtKB=O43566	Regulator of G-protein signaling 14	IDA	8756726	PubMed	PTHR10845:SF179	REGULATOR OF G-PROTEIN SIGNALING 14
P00005	Angiogenesis	P00203	Erk	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	BOVIN|Ensembl=ENSBTAG00000003512|UniProtKB=E1BPX8	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF358	MYOSIN-7B
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01435	SWI/SNF	ARATH|TAIR=AT5G14170|UniProtKB=Q9FMT4	SWI/SNF complex component SNF12 homolog	ISS	11532957	PubMed	PTHR13844:SF22	SWI/SNF COMPLEX COMPONENT SNF12 HOMOLOG
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	10891487	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	PANTR|Ensembl=ENSPTRG00000023608|UniProtKB=H2QZZ2	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CANAL|CGD=CAL0064759|UniProtKB=Q5AKX0	Uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	IC	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IDA	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00019	Endothelin signaling pathway	P00589	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00584	Gs	HUMAN|HGNC=4392|UniProtKB=Q5JWF2	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas	RCA			PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00059	p53 pathway	G04699	BAI-1	RAT|RGD=1309703|UniProtKB=D4A831	Brain-specific angiogenesis inhibitor 3 (Predicted)	ISS			PTHR12011:SF40	ADHESION G PROTEIN-COUPLED RECEPTOR B3
P00037	Ionotropic glutamate receptor pathway	P01012	PICK	BOVIN|Gene=PICK1|UniProtKB=Q2T9M1	PRKCA-binding protein	ISS	12941441	PubMed	PTHR12141:SF1	PRKCA-BINDING PROTEIN
P00034	Integrin signalling pathway	P00940	Src	TAKRU|Ensembl=ENSTRUG00000004669|UniProtKB=H2SFA3	Tyrosine-protein kinase	IPI	8054685	PubMed	PTHR24418:SF181	TYROSINE-PROTEIN KINASE BLK
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IDA	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00012	Cadherin signaling pathway	P00467	alpha-catenin	PANTR|Ensembl=ENSPTRG00000017291|UniProtKB=H2QRK9	Catenin (Cadherin-associated protein), alpha 1, 102kDa	ISS	9362521	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00006	Apoptosis signaling pathway	P00260	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01451	Galpha	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05918	p38 MAPK pathway	P06015	p38gamma	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	RCA	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=4598|UniProtKB=O15303	Metabotropic glutamate receptor 6	IDA	12488551	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	BOVIN|Ensembl=ENSBTAG00000003054|UniProtKB=F1MC23	Tyrosine-protein kinase receptor	ISS	12644000	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=109503|UniProtKB=Q5RJH3	Cadherin-12	IDA	8120095	PubMed	PTHR24027:SF96	CADHERIN-12
P00059	p53 pathway	G04702	p53	MACMU|Ensembl=ENSMMUG00000008639|UniProtKB=P56424	Cellular tumor antigen p53	TAS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MACMU|Ensembl=ENSMMUG00000018178|UniProtKB=F7EA61	Uncharacterized protein	ISS			PTHR13140:SF369	UNCONVENTIONAL MYOSIN-VIIA
P06959	CCKR signaling map	G06986	CCND1	HUMAN|HGNC=1582|UniProtKB=P24385	G1/S-specific cyclin-D1	RCA	15116100	PubMed	PTHR10177:SF67	G1/S-SPECIFIC CYCLIN-D1
P00057	Wnt signaling pathway	P01457	GBeta	IXOSC|EnsemblGenome=ISCW009711|UniProtKB=B7Q3T6	THO complex subunit, putative	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01320	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00010	B cell activation	P00383	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IDA	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00057	Wnt signaling pathway	P01438	PP2A	MOUSE|MGI=MGI=2388481|UniProtKB=Q91V89	Protein Ppp2r5d	ISS	10092233	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	TAS	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P05916	Opioid prodynorphin pathway	P06002	G-protein	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00021	FGF signaling pathway	P00626	Spry	MACMU|Ensembl=ENSMMUG00000001848|UniProtKB=F7GQV4	Protein sprouty homolog 1	ISS	98117253	PubMed	PTHR12365:SF10	PROTEIN SPROUTY HOMOLOG 1
P00029	Huntington disease	P00799	JNK-2	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00036	Interleukin signaling pathway	P00965	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IDA	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	PANTR|Ensembl=ENSPTRG00000020039|UniProtKB=H2R9W1	Uncharacterized protein	ISS	92370677	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00005	Angiogenesis	P00193	SOS-1	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00648	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	IDA	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00552	Ras	CAEBR|Gene=CBG06092|UniProtKB=A8X0X5	Protein CBR-LET-60	ISS	12024031	PubMed	PTHR24070:SF385	GTPASE HRAS
P00021	FGF signaling pathway	P00642	MEK1-2	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00059	p53 pathway	P04609	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	12660731	PubMed	PTHR10048:SF14	PI-3 KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02738	De novo purine biosynthesis	P02907	dADP kinase	HUMAN|HGNC=20461|UniProtKB=Q9Y5B8	Nucleoside diphosphate kinase 7	ISS			PTHR43109:SF2	NUCLEOSIDE DIPHOSPHATE KINASE 7
P00005	Angiogenesis	P00219	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	176910	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P05917	Opioid proopiomelanocortin pathway	P06010	proopiomelanocortin	MOUSE|MGI=MGI=97742|UniProtKB=P01193	Pro-opiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PUCGT|EnsemblGenome=PGTG_05488|UniProtKB=E3K4I1	Actin	IDA	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00036	Interleukin signaling pathway	P00976	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00015	Circadian clock system	G01500	bmal1	RAT|RGD=62003|UniProtKB=Q9EPW1	Aryl hydrocarbon receptor nuclear translocator-like protein 1	ISS	11163178	PubMed	PTHR23042:SF52	ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	DROME|FlyBase=FBgn0263111|UniProtKB=P91645	Voltage-dependent calcium channel type A subunit alpha-1	ISS	8386525	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P02743	Formyltetrahydroformate biosynthesis	P02958	Dihydrofolate synthase	ECOLI|EcoGene=EG10327|UniProtKB=P08192	Bifunctional protein FolC	ISS			PTHR11136:SF0	DIHYDROFOLATE SYNTHETASE-RELATED
P04393	Ras Pathway	P04542	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00188	Ets	BOVIN|Ensembl=ENSBTAG00000002341|UniProtKB=A5PJG9	ETS1 protein	ISS	3060801	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00034	Integrin signalling pathway	P00948	Rho	HUMAN|HGNC=671|UniProtKB=P61587	Rho-related GTP-binding protein RhoE	ISS	11973360	PubMed	PTHR24072:SF24	RHO-RELATED GTP-BINDING PROTEIN RHOE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PANTR|Ensembl=ENSPTRG00000008496|UniProtKB=H2QBS3	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	BOVIN|Ensembl=ENSBTAG00000008026|UniProtKB=P01175	Oxytocin-neurophysin 1	ISS	6717565	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MONDO|Ensembl=ENSMODG00000016960|UniProtKB=F6V5G0	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00034	Integrin signalling pathway	P00932	FAK	DANRE|ZFIN=ZDB-GENE-020114-1|UniProtKB=F1QT14	Uncharacterized protein	IPI	12640026	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	DROME|FlyBase=FBgn0004177|UniProtKB=P23696	Serine/threonine-protein phosphatase PP2A	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00924	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IC	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	RAT|RGD=619731|UniProtKB=Q9QYP1	Low-density lipoprotein receptor-related protein 4	ISS	11907044	PubMed	PTHR44017:SF4	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4
P00009	Axon guidance mediated by netrin	P00359	NFAT	MOUSE|MGI=MGI=103296|UniProtKB=P97305	Nuclear factor of activated T-cells, cytoplasmic 3	IDA	9462517	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	MYCTU|EnsemblGenome=Rv2764c|UniProtKB=P9WFR9	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00056	VEGF signaling pathway	P01411	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00036	Interleukin signaling pathway	P00983	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00049	Parkinson disease	P01227	20S proteasome	DROME|FlyBase=FBgn0250843|UniProtKB=P12881	Proteasome subunit alpha type-1	TAS	12859888	PubMed	PTHR11599:SF12	PROTEASOME SUBUNIT ALPHA TYPE-RELATED
P00048	PI3 kinase pathway	P01188	Gbetagamma	IXOSC|EnsemblGenome=ISCW009711|UniProtKB=B7Q3T6	THO complex subunit, putative	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00059	p53 pathway	P01486	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00778	NMDA receptor	MACMU|Ensembl=ENSMMUG00000016675|UniProtKB=F6VTB5	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00004	Alzheimer disease-presenilin pathway	P00168	E-cadherin intracellular fragment	RAT|RGD=69279|UniProtKB=Q9R0T4	Cadherin-1	IDA	8120095	PubMed	PTHR24027:SF319	CADHERIN-1
P00029	Huntington disease	P00810	GAPDH	BOVIN|Ensembl=ENSBTAG00000014731|UniProtKB=P10096	Glyceraldehyde-3-phosphate dehydrogenase	IPI	8612237	PubMed	PTHR10836:SF51	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ORYSJ|EnsemblGenome=OS05G0106600|UniProtKB=Q65XH8	Os05g0106600 protein	IC	10974003	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P02756	N-acetylglucosamine metabolism	P03036	N-acetylglucosamine-6-phosphate deacetylase	BOVIN|Ensembl=ENSBTAG00000001022|UniProtKB=A7MBC0	N-acetylglucosamine-6-phosphate deacetylase	ISS			PTHR11113:SF14	N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE
P00053	T cell activation	P01306	Ras	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	IDA	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00025	Hedgehog signaling pathway	P00682	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	IDA	2372396	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00029	Huntington disease	P00789	PSD-95	RAT|RGD=68424|UniProtKB=P31016	Disks large homolog 4	TAS	12932731	PubMed	PTHR23119:SF33	DISKS LARGE HOMOLOG 4
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=620308|UniProtKB=P30936	Somatostatin receptor type 3	IDA	12562507	PubMed	PTHR24229:SF42	SOMATOSTATIN RECEPTOR TYPE 3
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	TAS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00054	Toll receptor signaling pathway	P01368	MKK2	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	DROME|FlyBase=FBgn0020622|UniProtKB=Q7KTZ2	Pi3K21B, isoform B	ISS	7937853	PubMed	PTHR10155:SF0	PI3K21B, ISOFORM B
P06587	Nicotine pharmacodynamics pathway	P06592	CHRNA6	MACMU|Ensembl=ENSMMUG00000000163|UniProtKB=F7HLV0	Uncharacterized protein	ISS	15155845	PubMed	PTHR18945:SF82	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-6
P00047	PDGF signaling pathway	P01174	Rho	CANLF|Ensembl=ENSCAFG00000000345|UniProtKB=F1P8C2	Uncharacterized protein	ISS			PTHR14166:SF15	SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 1
P04373	5HT1 type receptor mediated signaling pathway	P04407	K+ channel	HUMAN|HGNC=6278|UniProtKB=O14649	Potassium channel subfamily K member 3	ISS	15282272	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P05913	Enkephalin release	P05978	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	HUMAN|HGNC=144|UniProtKB=P63261	Actin, cytoplasmic 2	IC	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	ANOGA|EnsemblGenome=AGAP010929|UniProtKB=Q7PSI4	AGAP010929-PA	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	BOVIN|Gene=ACVR2B|UniProtKB=Q95126	Activin receptor type-2B	TAS	9395284	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	11956331	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00059	p53 pathway	P04634	Cdc2	MACMU|Ensembl=ENSMMUG00000018817|UniProtKB=F6ZHC1	Uncharacterized protein	ISS	1846803	PubMed	PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05943	GRK2	MOUSE|MGI=MGI=87940|UniProtKB=Q99MK8	Beta-adrenergic receptor kinase 1	RCA	10085131	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P04375	5HT3 type receptor mediated signaling pathway	P04422	5HT3 Rec	PANTR|Ensembl=ENSPTRG00000015677|UniProtKB=H2QNU3	Uncharacterized protein	ISS	7509203	PubMed	PTHR18945:SF764	5-HYDROXYTRYPTAMINE RECEPTOR 3C
P00046	Oxidative stress response	P01124	Myc	DANRE|ZFIN=ZDB-GENE-990415-162|UniProtKB=P52160	Transcriptional regulator Myc-A	TAS	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000005917|UniProtKB=F6QM53	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P02755	Methylmalonyl pathway	P03034	Methylmalonyl-CoA mutase	MYCTU|EnsemblGenome=Rv1492|UniProtKB=P9WJK7	Probable methylmalonyl-CoA mutase small subunit	ISS			PTHR43589:SF1	SUBFAMILY NOT NAMED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	IC	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	TAKRU|Ensembl=ENSTRUG00000012733|UniProtKB=H2U5K8	Uncharacterized protein	ISS			PTHR24070:SF289	SUBFAMILY NOT NAMED
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	87218499	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	CAEEL|WormBase=WBGene00000913|UniProtKB=G5EE01	DAF-18	ISS	9885576	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00023	General transcription regulation	P00664	TFIIH complex	HUMAN|HGNC=4658|UniProtKB=Q92759	General transcription factor IIH subunit 4	ISS			PTHR13152:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4
P00047	PDGF signaling pathway	P01153	GSK3	DICDI|dictyBase=DDB_G0272110|UniProtKB=P51136	Glycogen synthase kinase-3	ISS	7813009	PubMed	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00029	Huntington disease	P00786	ARF	ARATH|TAIR=AT3G62290|UniProtKB=Q9M1P5	ADP-ribosylation factor A1E	ISS	12932731	PubMed	PTHR11711:SF232	ADP-RIBOSYLATION FACTOR A1E
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MOUSE|MGI=MGI=1338824|UniProtKB=O54828	Regulator of G-protein signaling 9	IDA	8756726	PubMed	PTHR10845:SF170	REGULATOR OF G-PROTEIN SIGNALING 9
P06211	BMP/activin signaling pathway-drosophila	P06249	TLD	DROME|FlyBase=FBgn0003719|UniProtKB=P25723	Dorsal-ventral patterning protein tolloid	IDA	12925593	PubMed	PTHR43978:SF2	DORSAL-VENTRAL PATTERNING PROTEIN TOLLOID-RELATED
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P06959	CCKR signaling map	P07194	MAP2K1	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	RCA	12239223	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02771	Pyrimidine Metabolism	P03124	Methylmalonate Semialdehyde Dehydrogenase	SULSO|EnsemblGenome=SSO1218|UniProtKB=Q97YT9	Methylmalonate-semialdehyde dehydrogenase	ISS	11427726	PubMed	PTHR43866:SF4	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04557	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IDA	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00859	NFkappaB	RAT|RGD=3171|UniProtKB=Q63746	NF-kappa-B inhibitor alpha	ISS			PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MOUSE|MGI=MGI=1920960|UniProtKB=Q9CWF2	Tubulin beta-2B chain	ISS	9454836	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00034	Integrin signalling pathway	P00910	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8235613	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	ENTHI|EnsemblGenome=EHI_070730|UniProtKB=C4M5T0	Rho family GTPase	ISS	97082968	PubMed	PTHR24072:SF117	RHO-RELATED PROTEIN RACC
P00012	Cadherin signaling pathway	P00477	GSK3beta	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	IDA	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02777	Succinate to proprionate conversion	P03163	Methylmalonyl-CoA decarboxylase	MACMU|Ensembl=ENSMMUG00000015352|UniProtKB=F7GU93	Enoyl-CoA hydratase domain-containing protein 1 isoform 5	RCA			PTHR11941:SF27	ETHYLMALONYL-COA DECARBOXYLASE
P00047	PDGF signaling pathway	P01162	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00054	Toll receptor signaling pathway	P01375	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	IC	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01142	p90RSK	MOUSE|MGI=MGI=104558|UniProtKB=P18653	Ribosomal protein S6 kinase alpha-1	ISS	12213813	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00029	Huntington disease	P00788	Calpain	BOVIN|Ensembl=ENSBTAG00000012778|UniProtKB=Q27971	Calpain-2 catalytic subunit	ISS	11675509	PubMed	PTHR10183:SF268	CALPAIN-2 CATALYTIC SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	IGI	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00047	PDGF signaling pathway	P01160	IP3 receptor	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-9966|UniProtKB=Q6TH03	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04374	5HT2 type receptor mediated signaling pathway	P04413	K+ channel	RAT|RGD=621451|UniProtKB=Q9ES08	Potassium channel subfamily K member 9	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	MACMU|Ensembl=ENSMMUG00000000016|UniProtKB=F7HTL0	Adenylosuccinate synthetase isozyme 2	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00010	B cell activation	P00381	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	IGI	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MOUSE|MGI=MGI=3648102|UniProtKB=E9Q2K4	Actin-related protein 2/3 complex subunit 5	TAS	12473693	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P02742	Tetrahydrofolate biosynthesis	P02941	Dihydroneopterin aldolase	STRCO|EnsemblGenome=CAB42753|UniProtKB=Q9X8I0	Dihydroneopterin aldolase	ISS			PTHR42844:SF1	DIHYDRONEOPTERIN ALDOLASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04393	Ras Pathway	P04558	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00030	Hypoxia response via HIF activation	P00814	P300	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MACMU|Ensembl=ENSMMUG00000007154|UniProtKB=F7DHF4	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF149	REGULATOR OF G-PROTEIN SIGNALING 12
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IDA	188830	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=1306541|UniProtKB=D3ZVF3	Phosphoinositide-3-kinase, class 2, beta polypeptide (Predicted)	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	BOVIN|Ensembl=ENSBTAG00000013498|UniProtKB=Q75Z89	5-hydroxytryptamine receptor 2A	ISS	12441358	PubMed	PTHR24247:SF30	5-HYDROXYTRYPTAMINE RECEPTOR 2A
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	SCHPO|PomBase=SPBC32H8.12c|UniProtKB=P10989	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	CANLF|Gene=MYH1|UniProtKB=Q076A6	Myosin-1	ISS	89264452	PubMed	PTHR13140:SF484	MYOSIN-1
P00018	EGF receptor signaling pathway	P00540	MKK3,6	MOUSE|MGI=MGI=1346868|UniProtKB=O09110	Dual specificity mitogen-activated protein kinase kinase 3	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	10802295	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	MOUSE|MGI=MGI=88399|UniProtKB=P32211	Muscarinic acetylcholine receptor M4	ISS	10069496	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=11433|UniProtKB=Q16623	Syntaxin-1A	ISS	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00543	ERK1-2	LEIMA|EnsemblGenome=LmjF.10.0200|UniProtKB=Q4QHJ8	Putative mitogen-activated protein kinase	ISS			PTHR24055:SF148	SUBFAMILY NOT NAMED
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	PANTR|Ensembl=ENSPTRG00000004718|UniProtKB=H2Q5I0	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	HUMAN|HGNC=9509|UniProtKB=P49810	Presenilin-2	TAS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00053	T cell activation	P01318	PKC-theta	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00010	B cell activation	P00385	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	15470041	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00021	FGF signaling pathway	P00627	ERK1-2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	DANRE|ZFIN=ZDB-GENE-991207-24|UniProtKB=Q9PVF8	Catenin (Cadherin-associated protein), alpha	TAS	1768802	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00005	Angiogenesis	P00236	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	PANTR|Ensembl=ENSPTRG00000014012|UniProtKB=H2QL57	Uncharacterized protein	ISS	10778855	PubMed	PTHR44172:SF3	COLLAGEN ALPHA-1 VI  CHAIN
P02738	De novo purine biosynthesis	P02905	Amidophosphoribosyl transferase	CAEBR|Gene=CBG18013|UniProtKB=A8XST9	Amidophosphoribosyltransferase	ISS			PTHR11907:SF18	AMIDOPHOSPHORIBOSYLTRANSFERASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DANRE|ZFIN=ZDB-GENE-040426-2427|UniProtKB=F1Q6C0	Uncharacterized protein (Fragment)	ISS	3037538	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00211	GSK3beta	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	RCA	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00568	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05913	Enkephalin release	P05974	G-Protein (i)	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	BOVIN|Ensembl=ENSBTAG00000008026|UniProtKB=P01175	Oxytocin-neurophysin 1	ISS	9756087	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	BOVIN|Ensembl=ENSBTAG00000020756|UniProtKB=A6QLB8	GSK3A protein	ISS	2164470	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P05913	Enkephalin release	P05972	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1203729|UniProtKB=Q61194	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00566	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	MOUSE|MGI=MGI=1934950|UniProtKB=Q8BK63	Casein kinase I isoform alpha	IDA	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	RCA	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00021	FGF signaling pathway	P00624	14-3-3	CANLF|Ensembl=ENSCAFG00000031015|UniProtKB=J9P6N4	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	SCLS1|EnsemblGenome=SS1G_05445|UniProtKB=A7EJF2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00008	Axon guidance mediated by Slit/Robo	P00342	Slit	MACMU|Ensembl=ENSMMUG00000010428|UniProtKB=F7CX22	Uncharacterized protein	ISS	10432110	PubMed	PTHR24373:SF39	SLIT HOMOLOG 1 PROTEIN
P00057	Wnt signaling pathway	P01452	NFAT	HUMAN|HGNC=7775|UniProtKB=O95644	Nuclear factor of activated T-cells, cytoplasmic 1	IDA	9462517	PubMed	PTHR12533:SF5	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 1
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	RAT|RGD=621515|UniProtKB=P61954	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	ISS	2122451	PubMed	PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	CAEBR|Gene=CBG02401|UniProtKB=A8WUE7	Protein CBR-NMR-1	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00053	T cell activation	P01336	Jnk	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IGI	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	MOUSE|MGI=MGI=96549|UniProtKB=P01590	Interleukin-2 receptor subunit alpha	ISS	2987826	PubMed	PTHR10573:SF0	INTERLEUKIN-2 RECEPTOR SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DICDI|dictyBase=DDB_G0268744|UniProtKB=Q55EU6	Putative actin-23	IC	14684598	PubMed	PTHR11937:SF154	ACTIN-17-RELATED
P00057	Wnt signaling pathway	P01438	PP2A	ANOGA|EnsemblGenome=AGAP010172|UniProtKB=Q7PD38	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IDA	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	HUMAN|HGNC=9509|UniProtKB=P49810	Presenilin-2	IDA	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	RAT|RGD=621515|UniProtKB=P61954	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	ISS			PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	HUMAN|HGNC=4583|UniProtKB=Q16478	Glutamate receptor ionotropic, kainate 5	ISS	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008018|UniProtKB=F7EPG4	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00047	PDGF signaling pathway	P01147	Nck	RAT|RGD=1305965|UniProtKB=D4A3M8	Non-catalytic region of tyrosine kinase adaptor protein 2 (Predicted)	ISS	12874226	PubMed	PTHR44108:SF1	CYTOPLASMIC PROTEIN NCK2
P02741	Flavin biosynthesis	P02940	Riboflavin synthase	AQUAE|EnsemblGenome=aq_1707|UniProtKB=O67604	Riboflavin synthase	ISS			PTHR21098:SF0	RIBOFLAVIN SYNTHASE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00038	JAK/STAT signaling pathway	P01027	STAT	MOUSE|MGI=MGI=103039|UniProtKB=Q9WVL2	Signal transducer and activator of transcription 2	ISS	11786546	PubMed	PTHR11801:SF41	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 2
P00045	Notch signaling pathway	P01109	Aph-1	BOVIN|Ensembl=ENSBTAG00000021482|UniProtKB=Q3SZ69	Anterior pharynx defective 1 homolog A (C. elegans)	ISS	12110170	PubMed	PTHR12889:SF3	GAMMA-SECRETASE SUBUNIT APH-1A
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	STRCO|Gene=CAA22750|UniProtKB=Q9ZBH2	Putative aldehyde dehydrogenase	IC			PTHR43353:SF5	SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL
P00060	Ubiquitin proteasome pathway	P01491	E2	CHICK|Ensembl=ENSGALG00000008648|UniProtKB=Q9W6F3	Ubiquitin-conjugating enzyme	ISS			PTHR43898:SF4	UBIQUITIN-CONJUGATING ENZYME E2 A
P05915	Opioid proenkephalin pathway	P05993	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02916	dTMP kinase	THEMA|EnsemblGenome=TM_1099|UniProtKB=Q9X0I3	Thymidylate kinase	ISS			PTHR10344:SF1	THYMIDYLATE KINASE
P00056	VEGF signaling pathway	P01414	PLC-gamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00046	Oxidative stress response	P01135	p38	CAEBR|Gene=CBG01555|UniProtKB=A8WRD7	Mitogen-activated protein kinase	ISS	22138445	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00010	B cell activation	P00397	IKK	PANTR|Ensembl=ENSPTRG00000033948|UniProtKB=H2RBD4	Conserved helix-loop-helix ubiquitous kinase	ISS	12235208	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00046	Oxidative stress response	P01135	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	TAS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00021	FGF signaling pathway	P00634	MEKK1-5	MOUSE|MGI=MGI=1346876|UniProtKB=O35099	Mitogen-activated protein kinase kinase kinase 5	ISS	11730323	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00470	F-actin	DANRE|ZFIN=ZDB-GENE-050410-4|UniProtKB=Q56A35	Actin-related protein 2-B	ISS	10974003	PubMed	PTHR11937:SF149	ACTIN-RELATED PROTEIN 2-A-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CANLF|Ensembl=ENSCAFG00000003333|UniProtKB=F1PWT6	Uncharacterized protein	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00005	Angiogenesis	P00223	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	G06668	Rap1b	MOUSE|MGI=MGI=894315|UniProtKB=Q99JI6	Ras-related protein Rap-1b	RCA	8576107	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IC	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00052	TGF-beta signaling pathway	P01288	FKBP12	YEAST|SGD=S000005079|UniProtKB=P20081	FK506-binding protein 1	TAS			PTHR10516:SF341	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE
P00034	Integrin signalling pathway	P00920	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	HUMAN|HGNC=4241|UniProtKB=Q06210	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1	ISS			PTHR10937:SF2	GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE  ISOMERIZING  1
P05918	p38 MAPK pathway	P06023	MEF	MOUSE|MGI=MGI=99533|UniProtKB=Q63943	Myocyte-specific enhancer factor 2D	RCA			PTHR11945:SF23	MYOCYTE-SPECIFIC ENHANCER FACTOR 2D
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	IDA	15621031	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P04393	Ras Pathway	P04569	Cdc42	ANOGA|EnsemblGenome=AGAP002440|UniProtKB=Q17031	Cdc42 homolog	ISS	9658176	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00036	Interleukin signaling pathway	P00990	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04398	p53 pathway feedback loops 2	P04668	p53	BOVIN|Ensembl=ENSBTAG00000015460|UniProtKB=F1MKA9	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00056	VEGF signaling pathway	P01407	Erk	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00012	Cadherin signaling pathway	P00470	F-actin	BOVIN|Gene=ACTR2|UniProtKB=A7MB62	Actin-related protein 2	ISS	10974003	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02775	Salvage pyrimidine ribonucleotides	P03156	CDP kinase	HUMAN|HGNC=7851|UniProtKB=Q13232	Nucleoside diphosphate kinase 3	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01160	IP3 receptor	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	BOVIN|Ensembl=ENSBTAG00000034854|UniProtKB=F1N246	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04395	Vasopressin synthesis	P04597	Signal Peptide	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IC	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	MOUSE|MGI=MGI=95815|UniProtKB=P39087	Glutamate receptor ionotropic, kainate 2	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00012	Cadherin signaling pathway	P00465	TCF/LEF	MACMU|Ensembl=ENSMMUG00000023256|UniProtKB=F7HPX5	Uncharacterized protein	ISS	11266476	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=1930705|UniProtKB=P61264	Syntaxin-1B	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT1G10210|UniProtKB=Q39021	Mitogen-activated protein kinase 1	ISS	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00048	PI3 kinase pathway	P01192	p110	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IGI	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MONDO|Ensembl=ENSMODG00000015246|UniProtKB=F6UJF5	Uncharacterized protein	ISS	11431030	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00047	PDGF signaling pathway	P01167	Ets	MOUSE|MGI=MGI=109637|UniProtKB=P70459	ETS domain-containing transcription factor ERF	ISS	15298723	PubMed	PTHR11849:SF31	ETS DOMAIN-CONTAINING TRANSCRIPTION FACTOR ERF
P00003	Alzheimer disease-amyloid secretase pathway	P00093	Tip60	PANTR|Ensembl=ENSPTRG00000010275|UniProtKB=H2QEZ6	Amyloid beta (A4) protein-binding, family A, member 3	ISS			PTHR12345:SF9	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 3
P00034	Integrin signalling pathway	P00944	Actin	MONDO|Ensembl=ENSMODG00000000365|UniProtKB=F6R9F4	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00047	PDGF signaling pathway	P01146	Ikk	BOVIN|Ensembl=ENSBTAG00000007591|UniProtKB=Q95KV1	Inhibitor of nuclear factor kappa-B kinase subunit alpha	RCA			PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00925	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00034	Integrin signalling pathway	P00951	Jnk	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00056	VEGF signaling pathway	P01414	PLC-gamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00047	PDGF signaling pathway	P01153	GSK3	ARATH|TAIR=AT5G14640|UniProtKB=Q8VZD5	Shaggy-related protein kinase epsilon	ISS	21361340	gi	PTHR24057:SF36	SHAGGY-RELATED PROTEIN KINASE EPSILON
P04398	p53 pathway feedback loops 2	P04661	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00046	Oxidative stress response	P01135	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	TAS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MOUSE|MGI=MGI=95818|UniProtKB=Q61626	Glutamate receptor ionotropic, kainate 5	ISS	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00010	B cell activation	P00376	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00034	Integrin signalling pathway	P00925	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IC	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	MOUSE|MGI=MGI=109482|UniProtKB=P97445	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	8386525	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00010	B cell activation	P00371	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CANLF|Ensembl=ENSCAFG00000015708|UniProtKB=F2Z4N0	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00586	Gq	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00924	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P05731	GABA-B receptor II signaling	P05752	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00775	Rac	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS	12874273	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00029	Huntington disease	P00784	MAPKK7	HUMAN|HGNC=6847|UniProtKB=O14733	Dual specificity mitogen-activated protein kinase kinase 7	RCA	15039780	PubMed	PTHR24361:SF387	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TRIVA|Gene=TVAG_337240|UniProtKB=P90623	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04393	Ras Pathway	P04578	Rho	HUMAN|HGNC=667|UniProtKB=P61586	Transforming protein RhoA	ISS	12169092	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00011	Blood coagulation	P00458	GP IIIa	BOVIN|Ensembl=ENSBTAG00000009987|UniProtKB=F1MTN1	Integrin beta	ISS	20069419	gi	PTHR10082:SF25	INTEGRIN BETA-3
P02755	Methylmalonyl pathway	P03033	Propionyl-CoA carboxylase	SULSO|EnsemblGenome=SSO2463|UniProtKB=Q97VY8	Propionyl-CoA carboxylase beta subunit (PpcB)	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P02738	De novo purine biosynthesis	P02898	Phosphoribosylformylglycinamide  synthase	BACSU|EnsemblGenome=BSU06480|UniProtKB=P12042	Phosphoribosylformylglycinamidine synthase subunit PurL	ISS			PTHR43555:SF1	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00877	MLCK	HUMAN|HGNC=16243|UniProtKB=Q9H1R3	Myosin light chain kinase 2, skeletal/cardiac muscle	IDA	600922	OMIM	PTHR45210:SF1	MYOSIN LIGHT CHAIN KINASE 2, SKELETAL/CARDIAC MUSCLE
P00056	VEGF signaling pathway	P01405	VRAP	MOUSE|MGI=MGI=1351596|UniProtKB=Q9QXK9	SH2 domain-containing protein 2A	IDA	604514	OMIM	PTHR14388:SF9	SH2 DOMAIN-CONTAINING PROTEIN 2A
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	SYNY3|EnsemblGenome=BAA18596|UniProtKB=P74494	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00046	Oxidative stress response	P01132	c-jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ORYSJ|EnsemblGenome=OS03G0298400|UniProtKB=Q8W422	26S protease regulatory subunit 4, putative, expressed	ISS			PTHR23073:SF42	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	MOUSE|MGI=MGI=106028|UniProtKB=Q62159	Rho-related GTP-binding protein RhoC	IDA	14871999	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00047	PDGF signaling pathway	P01168	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	ISS	96009592	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00048	PI3 kinase pathway	P01199	Galpha	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000020399|UniProtKB=F6U813	Adenosine receptor A2	ISS			PTHR24246:SF18	ADENOSINE RECEPTOR A2B
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PANTR|Ensembl=ENSPTRG00000007085|UniProtKB=H2Q9G6	Uncharacterized protein	ISS			PTHR13140:SF313	UNCONVENTIONAL MYOSIN-VC
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00635	FRS2	CHICK|Ensembl=ENSGALG00000009966|UniProtKB=E1C021	Uncharacterized protein	ISS	10464310	PubMed	PTHR21258:SF40	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00048	PI3 kinase pathway	P01192	p110	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	CANLF|Ensembl=ENSCAFG00000017516|UniProtKB=E2REK6	Uncharacterized protein	ISS			PTHR23050:SF311	CALMODULIN
P00049	Parkinson disease	P01235	Fyn kinase	DANRE|ZFIN=ZDB-GENE-030903-5|UniProtKB=Q6EWH2	Tyrosine-protein kinase fyna	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P05734	Synaptic vesicle trafficking	P05770	Munc18	MACMU|Ensembl=ENSMMUG00000016421|UniProtKB=F7FLD8	Syntaxin-binding protein 1 isoform a	ISS	8108429	PubMed	PTHR11679:SF35	SYNTAXIN-BINDING PROTEIN 1
P00049	Parkinson disease	P01235	Fyn kinase	MACMU|Ensembl=ENSMMUG00000014635|UniProtKB=F7G2C9	Tyrosine-protein kinase	ISS			PTHR24418:SF296	TYROSINE-PROTEIN KINASE FRK
P00034	Integrin signalling pathway	P00907	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01319	PAK	ORNAN|Ensembl=ENSOANG00000002406|UniProtKB=F7BAS2	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00019	Endothelin signaling pathway	P00590	IP3 R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04393	Ras Pathway	P04570	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00018	EGF receptor signaling pathway	P00545	JNK1-3	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01443	Phospholipase C	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	BOVIN|Ensembl=ENSBTAG00000037794|UniProtKB=E1BP87	Uncharacterized protein	IEP	10938134	PubMed	PTHR13140:SF681	MYOSIN-4
P00021	FGF signaling pathway	P00644	p38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=1261834|UniProtKB=O70283	Protein Wnt-2b	IDA	11266476	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01080	AChE	MACMU|Ensembl=ENSMMUG00000021257|UniProtKB=F7HPD6	Carboxylic ester hydrolase	ISS	87080761	PubMed	PTHR43918:SF3	ACETYLCHOLINESTERASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00897	SHIP2	BOVIN|Ensembl=ENSBTAG00000019167|UniProtKB=E1BBJ7	Uncharacterized protein	ISS	10381377	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P06215	MYO signaling pathway	P06316	WIT	DROME|FlyBase=FBgn0024179|UniProtKB=M9PE88	Receptor protein serine/threonine kinase	IDA	11856529	PubMed	PTHR23255:SF52	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P04393	Ras Pathway	P04570	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MONDO|Ensembl=ENSMODG00000008701|UniProtKB=F6PWM3	Uncharacterized protein	ISS	12549854	PubMed	PTHR11309:SF22	FRIZZLED-3
P05918	p38 MAPK pathway	P06031	p38alpha	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00007	Axon guidance mediated by semaphorins	P00340	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00030	Hypoxia response via HIF activation	P00814	P300	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IGI	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P06664	Gonadotropin-releasing hormone receptor pathway	P06780	ActRII/IIB	MOUSE|MGI=MGI=87912|UniProtKB=P27040	Activin receptor type-2B	RCA	11252892	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01408	Akt/PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	HUMAN|HGNC=7573|UniProtKB=P11055	Myosin-3	ISS	10938134	PubMed	PTHR13140:SF427	MYOSIN-3
P00012	Cadherin signaling pathway	P00470	F-actin	XENTR|Xenbase=XB-GENE-491618|UniProtKB=Q6P378	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00004	Alzheimer disease-presenilin pathway	P00160	Nectin 1alpha	MOUSE|MGI=MGI=1926483|UniProtKB=Q9JKF6	Nectin-1	IDA	12376527	PubMed	PTHR23277:SF69	NECTIN-1
P00048	PI3 kinase pathway	P01192	p110	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	IGI	129387	gi	PTHR10048:SF14	PI-3 KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	RCA	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00030	Hypoxia response via HIF activation	P00819	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	TAS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	CAEEL|WormBase=WBGene00001680|UniProtKB=Q20636	Guanine nucleotide-binding protein subunit beta-2	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04393	Ras Pathway	P04560	AP1	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	MACMU|Gene=CHRM1|UniProtKB=P56489	Muscarinic acetylcholine receptor M1	ISS	10069496	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00005	Angiogenesis	P00181	SHP2	DANRE|ZFIN=ZDB-GENE-030131-5911|UniProtKB=F1QZU5	Tyrosine-protein phosphatase non-receptor type	ISS	8096088	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	BOVIN|Ensembl=ENSBTAG00000007882|UniProtKB=G3X7Z2	Uncharacterized protein	ISS	14624853	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00778	NMDA receptor	RAT|RGD=2736|UniProtKB=P35439	Glutamate receptor ionotropic, NMDA 1	IDA	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	ANOGA|EnsemblGenome=AGAP011481|UniProtKB=Q7PMY1	AGAP011481-PA (Fragment)	ISS	8143856	PubMed	PTHR24247:SF117	5-HYDROXYTRYPTAMINE RECEPTOR 2A-RELATED
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00005	Angiogenesis	P00206	Wnt	PANTR|Ensembl=ENSPTRG00000004893|UniProtKB=H2Q5U4	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00019	Endothelin signaling pathway	P00568	PKC	CANAL|CGD=CAL0003231|UniProtKB=Q5ANK2	Protein kinase C	IGI	96408767	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00005	Angiogenesis	P00183	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	95096035	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00021	FGF signaling pathway	P00643	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01236	Casein kinase II	YEAST|SGD=S000002987|UniProtKB=P43639	Casein kinase II subunit beta	IDA	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P04397	p53 pathway by glucose deprivation	P04641	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P02746	Heme biosynthesis	P02979	porphobilinogen synthase	SYNY3|EnsemblGenome=BAA18067|UniProtKB=P77969	Delta-aminolevulinic acid dehydratase	ISS			PTHR11458:SF0	DELTA-AMINOLEVULINIC ACID DEHYDRATASE
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	BOVIN|Ensembl=ENSBTAG00000008967|UniProtKB=P61223	Ras-related protein Rap-1b	ISS	8576107	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00053	T cell activation	P01300	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00049	Parkinson disease	P01236	Casein kinase II	DANRE|ZFIN=ZDB-GENE-990415-29|UniProtKB=Q91398	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	CANLF|Ensembl=ENSCAFG00000016387|UniProtKB=E2QV83	Uncharacterized protein	ISS	8406481	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MONDO|Ensembl=ENSMODG00000004799|UniProtKB=F6VM87	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00019	Endothelin signaling pathway	P00586	Gq	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05913	Enkephalin release	P05974	G-Protein (i)	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00947	Laminin	PANTR|Ensembl=ENSPTRG00000001761|UniProtKB=H2Q0R1	Uncharacterized protein	ISS	2538453	PubMed	PTHR10574:SF270	LAMININ SUBUNIT GAMMA-1
P00012	Cadherin signaling pathway	P00474	Wnt	RAT|RGD=69079|UniProtKB=M0R9D3	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	HUMAN|HGNC=1392|UniProtKB=Q15878	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	11976940	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00009	Axon guidance mediated by netrin	P00366	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	PANTR|Ensembl=ENSPTRG00000007536|UniProtKB=H2QA71	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF144	REGULATOR OF G-PROTEIN SIGNALING 11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS			PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MACMU|Ensembl=ENSMMUG00000012546|UniProtKB=F7E840	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IGI	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000022548|UniProtKB=F6Y9J9	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00005	Angiogenesis	P00193	SOS-1	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	ISS			PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00025	Hedgehog signaling pathway	P00689	Patched	CANLF|Ensembl=ENSCAFG00000001246|UniProtKB=F1PNE0	Uncharacterized protein	ISS	8647801	PubMed	PTHR10796:SF61	PROTEIN PATCHED HOMOLOG 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00011	Blood coagulation	P00434	FXIa	PANTR|Gene=F9|UniProtKB=Q95ND7	Coagulation factor IX	ISS	182609	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DICDI|dictyBase=DDB_G0289487|UniProtKB=P07829	Actin-3	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00053	T cell activation	P01311	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	IC	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DROME|FlyBase=FBgn0000045|UniProtKB=P02574	Actin, larval muscle	IC	11889126	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	HUMAN|HGNC=3026|UniProtKB=P21918	D(1B) dopamine receptor	ISS	9700720	PubMed	PTHR43893:SF8	D 1B  DOPAMINE RECEPTOR
P02747	Histidine biosynthesis	P02990	Histidinol-phosphatase	DEIRA|EnsemblGenome=DR_0470|UniProtKB=Q9RX45	Probable histidinol-phosphatase	ISS			PTHR21039:SF0	HISTIDINOL-PHOSPHATASE
P00021	FGF signaling pathway	P00642	MEK1-2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008018|UniProtKB=F7EPG4	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P04393	Ras Pathway	P04572	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00036	Interleukin signaling pathway	P00971	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	9763606	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00321	HSP70	MONDO|Ensembl=ENSMODG00000023945|UniProtKB=F6V652	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF216	HEAT SHOCK-RELATED 70 KDA PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04393	Ras Pathway	P04572	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00047	PDGF signaling pathway	P01159	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00029	Huntington disease	P00796	Kainate receptor	PANTR|Ensembl=ENSPTRG00000000543|UniProtKB=H2PYN8	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95815|UniProtKB=P39087	Glutamate receptor ionotropic, kainate 2	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	CHICK|Ensembl=ENSGALG00000000681|UniProtKB=E1C3P6	Uncharacterized protein	ISS	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00053	T cell activation	P01308	ZAP-70	PANTR|Ensembl=ENSPTRG00000012259|UniProtKB=H2QIE3	Tyrosine-protein kinase	ISS	1423621	PubMed	PTHR24418:SF369	TYROSINE-PROTEIN KINASE ZAP-70
P00029	Huntington disease	P00775	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05730	Endogenous cannabinoid signaling	P05751	Galpha	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00053	T cell activation	P01336	Jnk	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00037	Ionotropic glutamate receptor pathway	P01026	KA	PANTR|Ensembl=ENSPTRG00000018449|UniProtKB=H2QTG5	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00053	T cell activation	P01332	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00012	Cadherin signaling pathway	P00475	Frizzled	BOVIN|Ensembl=ENSBTAG00000020590|UniProtKB=G3N2W8	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF34	FRIZZLED-2
P00019	Endothelin signaling pathway	P00568	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IGI	3755548	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	SYNY3|EnsemblGenome=BAA18596|UniProtKB=P74494	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00205	GAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	227170	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01154	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00009	Axon guidance mediated by netrin	P00357	Netrin	MACMU|Ensembl=ENSMMUG00000000004|UniProtKB=F7GVW8	Uncharacterized protein	ISS			PTHR10574:SF292	NETRIN-3
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P06664	Gonadotropin-releasing hormone receptor pathway	P06831	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	RCA	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CANLF|Gene=MYH1|UniProtKB=Q076A6	Myosin-1	ISS	89264452	PubMed	PTHR13140:SF484	MYOSIN-1
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	HUMAN|HGNC=1952|UniProtKB=P20309	Muscarinic acetylcholine receptor M3	TAS	8100450	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02776	Serine glycine biosynthesis	P03157	Phosphoserine aminotransferase	HUMAN|HGNC=19129|UniProtKB=Q9Y617	Phosphoserine aminotransferase	ISS	20886743	gi	PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ORYSJ|EnsemblGenome=OS03G0836000|UniProtKB=Q10AZ4	Actin-3	ISS	11889126	PubMed	PTHR11937:SF254	ACTIN-1-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00005	Angiogenesis	P00255	Notch	HUMAN|HGNC=7881|UniProtKB=P46531	Neurogenic locus notch homolog protein 1	IDA	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00048	PI3 kinase pathway	P01198	FOXO	HUMAN|HGNC=3821|UniProtKB=O43524	Forkhead box protein O3	TAS	10102273	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	BOVIN|Ensembl=ENSBTAG00000011960|UniProtKB=P33097	Aspartate aminotransferase, cytoplasmic	ISS			PTHR11879:SF3	ASPARTATE AMINOTRANSFERASE, CYTOPLASMIC
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02920	dCTP deaminase	SCHPO|PomBase=SPBC16D10.10|UniProtKB=O94642	tRNA-specific adenosine deaminase subunit tad2	ISS			PTHR11079:SF92	TRNA-SPECIFIC ADENOSINE DEAMINASE 2
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	ISS	11319238	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00010	B cell activation	P00398	IP3R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	IGI	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P05731	GABA-B receptor II signaling	P05756	GABA-B receptor	BOVIN|Ensembl=ENSBTAG00000017239|UniProtKB=F1MF15	Uncharacterized protein	ISS	9872315	PubMed	PTHR10519:SF42	GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00046	Oxidative stress response	P01133	Max	MOUSE|MGI=MGI=96921|UniProtKB=P28574	Protein max	ISS	11274345	PubMed	PTHR10328:SF3	PROTEIN MAX
P00019	Endothelin signaling pathway	P00570	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00590	IP3 R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00005	Angiogenesis	P00219	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	CHICK|Ensembl=ENSGALG00000012894|UniProtKB=P30372	Muscarinic acetylcholine receptor M2	TAS	11166329	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00010	B cell activation	P00385	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12874273	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00013	Cell cycle	P00480	Proteasome	RAT|RGD=1305236|UniProtKB=B0BN93	26S proteasome non-ATPase regulatory subunit 13	ISS	10225435	PubMed	PTHR10539:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13
P00010	B cell activation	P00381	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	IC	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00047	PDGF signaling pathway	P01167	Ets	HUMAN|HGNC=17257|UniProtKB=O95238	SAM pointed domain-containing Ets transcription factor	ISS	15298723	PubMed	PTHR11849:SF182	SAM POINTED DOMAIN-CONTAINING ETS TRANSCRIPTION FACTOR
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	RAT|RGD=620761|UniProtKB=Q9R172	Neurogenic locus notch homolog protein 3	IDA	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00034	Integrin signalling pathway	P00941	Integrin alpha	CANLF|Ensembl=ENSCAFG00000011346|UniProtKB=F6XF95	Uncharacterized protein	ISS	3487386	PubMed	PTHR23220:SF26	INTEGRIN ALPHA-10
P00036	Interleukin signaling pathway	P00965	ERK	BOVIN|Ensembl=ENSBTAG00000001014|UniProtKB=A5PKJ4	Mitogen-activated protein kinase 7	ISS	12912994	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00036	Interleukin signaling pathway	P00965	ERK	BOVIN|Ensembl=ENSBTAG00000001014|UniProtKB=A5PKJ4	Mitogen-activated protein kinase 7	ISS	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P04398	p53 pathway feedback loops 2	P04658	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00056	VEGF signaling pathway	P01415	MAPKAPK2/3	PANTR|Ensembl=ENSPTRG00000014968|UniProtKB=H2QMP5	Mitogen-activated protein kinase-activated protein kinase 3	ISS	11157753	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00005	Angiogenesis	P00211	GSK3beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	HUMAN|HGNC=6855|UniProtKB=Q99759	Mitogen-activated protein kinase kinase kinase 3	IGI	11730323	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	HUMAN|HGNC=18854|UniProtKB=Q8TEY5	Cyclic AMP-responsive element-binding protein 3-like protein 4	ISS	608972	OMIM	PTHR22952:SF105	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 4
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00005	Angiogenesis	P00252	Grb2	BOVIN|Ensembl=ENSBTAG00000003707|UniProtKB=A6QLK6	GRB2-related adapter protein	ISS			PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P04392	P53 pathway feedback loops 1	P04539	p53	PANTR|Ensembl=ENSPTRG00000015733|UniProtKB=H2QNY5	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CANLF|Ensembl=ENSCAFG00000013755|UniProtKB=Q49LX5	Somatostatin receptor type 1	ISS	12181435	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P05913	Enkephalin release	G06046	preproenkephalin mRNA	HUMAN|HGNC=8820|UniProtKB=P01213	Proenkephalin-B	ISS	131330	OMIM	PTHR11438:SF4	PROENKEPHALIN-B
P00021	FGF signaling pathway	P00648	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00227	PLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	IDA	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P05913	Enkephalin release	P05977	G-Protein (s)	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00018	EGF receptor signaling pathway	P00539	14-3-3	MOUSE|MGI=MGI=1891831|UniProtKB=O70456	14-3-3 protein sigma	ISS	10407019	PubMed	PTHR18860:SF14	14-3-3 PROTEIN SIGMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	PANTR|Ensembl=ENSPTRG00000004566|UniProtKB=H2Q597	Uncharacterized protein	ISS	11583304	PubMed	PTHR11339:SF361	VON WILLEBRAND FACTOR-RELATED
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	BOVIN|Gene=MYO10|UniProtKB=P79114	Unconventional myosin-X	IC			PTHR13140:SF276	UNCONVENTIONAL MYOSIN-X
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	XENTR|Xenbase=XB-GENE-5752629|UniProtKB=F6UBB9	Uncharacterized protein	ISS	SYT1_BOVIN	SPACC	PTHR10024:SF239	SYNAPTOTAGMIN-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00010	B cell activation	P00373	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IGI	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06850	PKCs(3)	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00256	PLC-gamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02757	O-antigen biosynthesis	P03047	dTDP-4-dehydrorhamnose 3,5-epimerase	GLOVI|Gene=BAC91643|UniProtKB=Q7NF25	dTDP-4-dehydrorhamnose 3,5-epimerase	ISS			PTHR21047:SF2	DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	IDA	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04393	Ras Pathway	P04558	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00018	EGF receptor signaling pathway	P00546	GAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	8262392	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	RCA	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00373	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IGI	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00021	FGF signaling pathway	P00627	ERK1-2	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00052	TGF-beta signaling pathway	P01292	RSmads	TAKRU|Ensembl=ENSTRUG00000001196|UniProtKB=H2RRM8	Mothers against decapentaplegic homolog	ISS			PTHR13703:SF41	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 9
P00008	Axon guidance mediated by Slit/Robo	P00342	Slit	PANTR|Ensembl=ENSPTRG00000024331|UniProtKB=H2R4B4	Uncharacterized protein	ISS	10432110	PubMed	PTHR24373:SF107	SLIT HOMOLOG 2 PROTEIN
P04393	Ras Pathway	P04542	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000007445|UniProtKB=F6SWI4	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00029	Huntington disease	P00780	Microtubule	DROME|FlyBase=FBgn0003889|UniProtKB=P61857	Tubulin beta-2 chain	IDA	9454836	PubMed	PTHR11588:SF155	TUBULIN BETA-2 CHAIN
P00053	T cell activation	P01312	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IDA	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	MOUSE|MGI=MGI=102522|UniProtKB=Q8R3Z5	Voltage-dependent L-type calcium channel subunit beta-1	ISS	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00211	GSK3beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00045	Notch signaling pathway	P01110	Presenilin	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	ISS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00059	p53 pathway	P04623	CBP	CAEEL|WormBase=WBGene00000366|UniProtKB=P34545	Protein cbp-1	ISS	10823891	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06850	PKCs(3)	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6854|UniProtKB=Q9Y2U5	Mitogen-activated protein kinase kinase kinase 2	ISS			PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04393	Ras Pathway	P04553	PAK	MONDO|Ensembl=ENSMODG00000005255|UniProtKB=F7G800	Uncharacterized protein	ISS	11259591	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00005	Angiogenesis	P00206	Wnt	PANTR|Ensembl=ENSPTRG00000001108|UniProtKB=H2PZP0	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00029	Huntington disease	P00797	p53	MACMU|Ensembl=ENSMMUG00000008639|UniProtKB=P56424	Cellular tumor antigen p53	ISS	11313951	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00006	Apoptosis signaling pathway	P00269	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	18479080	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P02734	Chorismate biosynthesis	P02873	Shikimate dehydrogenase	DEIRA|EnsemblGenome=DR_1173|UniProtKB=Q9RV57	Shikimate dehydrogenase (NADP(+))	ISS			PTHR21089:SF1	BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE/SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00012	Cadherin signaling pathway	P00470	F-actin	MONBE|Gene=37852|UniProtKB=A9V489	Predicted protein	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000000843|UniProtKB=H2QZN8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	THEKO|EnsemblGenome=TK1280|UniProtKB=Q5JGN1	Transcription initiation factor IIB 1	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P00046	Oxidative stress response	P01132	c-jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00024	Glycolysis	P00678	Enolase	MOUSE|MGI=MGI=95393|UniProtKB=P17182	Alpha-enolase	ISS	99439677	PubMed	PTHR11902:SF12	ALPHA-ENOLASE
P00029	Huntington disease	P00805	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00645	Rac	DICDI|dictyBase=DDB_G0277869|UniProtKB=P34144	Rho-related protein rac1A	ISS	12932731	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000001962|UniProtKB=F6V2H6	Uncharacterized protein	ISS	8444355	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00010	B cell activation	P00385	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000012820|UniProtKB=F1MDL3	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P04393	Ras Pathway	P04558	p38	DANRE|ZFIN=ZDB-GENE-990415-257|UniProtKB=O42376	Mitogen-activated protein kinase 12	ISS	11707292	PubMed	PTHR24055:SF339	MITOGEN-ACTIVATED PROTEIN KINASE 12
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00034	Integrin signalling pathway	P00949	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	10982827	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00018	EGF receptor signaling pathway	P00559	MEK1-2	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00219	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	BOVIN|Gene=ADRBK2|UniProtKB=P26818	Beta-adrenergic receptor kinase 2	IDA	8288567	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=103077|UniProtKB=Q64704	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MOUSE|MGI=MGI=104589|UniProtKB=P63268	Actin, gamma-enteric smooth muscle	IC	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00019	Endothelin signaling pathway	P00586	Gq	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00057	Wnt signaling pathway	P01454	betaTrCP	BOVIN|Ensembl=ENSBTAG00000015376|UniProtKB=F1MLG0	Uncharacterized protein	ISS	12628165	PubMed	PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-478663|UniProtKB=F7EG64	Protein kinase C delta type	ISS	11880265	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IC	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04393	Ras Pathway	P04542	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00013	Cell cycle	P00481	APC	MACMU|Ensembl=ENSMMUG00000004432|UniProtKB=F7GPG7	Anaphase-promoting complex subunit 10	ISS	7657035	gi	PTHR12936:SF0	ANAPHASE-PROMOTING COMPLEX SUBUNIT 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	BOVIN|Ensembl=ENSBTAG00000013298|UniProtKB=A4IFJ5	Cytosolic phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4401|UniProtKB=O14775	Guanine nucleotide-binding protein subunit beta-5	IC	10051575	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00012	Cadherin signaling pathway	P00474	Wnt	MACMU|Ensembl=ENSMMUG00000004904|UniProtKB=F7CJE4	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P00050	Plasminogen activating cascade	P01257	tPA	BOVIN|Ensembl=ENSBTAG00000001244|UniProtKB=Q28198	Tissue-type plasminogen activator	ISS	2499868	gi	PTHR44617:SF1	TISSUE-TYPE PLASMINOGEN ACTIVATOR
P00056	VEGF signaling pathway	P01409	cPLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00053	T cell activation	P01311	Raf	MOUSE|MGI=MGI=88190|UniProtKB=P28028	Serine/threonine-protein kinase B-raf	IDA	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01174	Rho	PANTR|Ensembl=ENSPTRG00000033931|UniProtKB=H2RCZ1	Rho GTPase activating protein 4	ISS			PTHR14166:SF16	RHO GTPASE-ACTIVATING PROTEIN 4
P00021	FGF signaling pathway	P00632	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00780	Microtubule	STRPU|EnsemblGenome=SPU_014285|UniProtKB=W4YEV4	Uncharacterized protein	ISS			PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00049	Parkinson disease	P01219	SAPK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	NAS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00034	Integrin signalling pathway	P00942	Fyn	DANRE|ZFIN=ZDB-GENE-030903-5|UniProtKB=Q6EWH2	Tyrosine-protein kinase fyna	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P04393	Ras Pathway	P04547	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00011	Blood coagulation	P00434	FXIa	MOUSE|MGI=MGI=99481|UniProtKB=Q91Y47	Coagulation factor XI	ISS	13811665	gi	PTHR44459:SF1	COAGULATION FACTOR XI
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00007	Axon guidance mediated by semaphorins	P00340	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00029	Huntington disease	P00775	Rac	CHICK|Ensembl=ENSGALG00000002859|UniProtKB=F6UBD2	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_127488|UniProtKB=C3XYC7	Putative uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00049	Parkinson disease	P01242	Casein kinase I	MONDO|Ensembl=ENSMODG00000003587|UniProtKB=F7FPX9	Uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	CHICK|Ensembl=ENSGALG00000013785|UniProtKB=E1BS74	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00029	Huntington disease	P00775	Rac	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS	15470041	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00036	Interleukin signaling pathway	P00983	Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	IC	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P05913	Enkephalin release	P05972	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	HUMAN|HGNC=172|UniProtKB=P36896	Activin receptor type-1B	TAS	10683140	PubMed	PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P00017	DNA replication	P00527	Histones	NEUCR|EnsemblGenome=EFNCRG00000001780|UniProtKB=P07041	Histone H3	ISS	20448842	PubMed	PTHR11426:SF169	HISTONE H3
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	MOUSE|MGI=MGI=1351341|UniProtKB=Q68EF4	Metabotropic glutamate receptor 4	IC	12488551	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00014	Cholesterol biosynthesis	P00490	Dimethylallyl trans-transferase	HUMAN|HGNC=17759|UniProtKB=Q5T2R2	Decaprenyl-diphosphate synthase subunit 1	IC			PTHR12001:SF47	DECAPRENYL-DIPHOSPHATE SYNTHASE SUBUNIT 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00006	Apoptosis signaling pathway	P00302	ATF	HUMAN|HGNC=2349|UniProtKB=Q99941	Cyclic AMP-dependent transcription factor ATF-6 beta	ISS	11390664	PubMed	PTHR22952:SF168	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-6 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	PANTR|Ensembl=ENSPTRG00000008999|UniProtKB=H2QCN3	C-C motif chemokine	ISS			PTHR12015:SF98	C-C MOTIF CHEMOKINE 2
P00019	Endothelin signaling pathway	P00587	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P06211	BMP/activin signaling pathway-drosophila	P06256	Full-length  BMP orthologous ligand	DROME|FlyBase=FBgn0024913|UniProtKB=O61643	Inhibin beta chain	RCA	9618266	PubMed	PTHR11848:SF133	INHIBIN BETA A CHAIN
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	RAT|RGD=1307535|UniProtKB=G3V928	Protein Lrp1	ISS	11907044	PubMed	PTHR44025:SF2	PROLOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00046	Oxidative stress response	P01121	MKK3/6	PANTR|Ensembl=ENSPTRG00000009588|UniProtKB=H2QZW5	Mitogen-activated protein kinase kinase 6	RCA			PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	BOVIN|Gene=KCNJ5|UniProtKB=F1MYR9	G protein-activated inward rectifier potassium channel 4	ISS	2433589	PubMed	PTHR11767:SF52	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 4
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	IC	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00059	p53 pathway	P04609	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	ISS	12660731	PubMed	PTHR10048:SF14	PI-3 KINASE
P05913	Enkephalin release	G06046	preproenkephalin mRNA	MACMU|Ensembl=ENSMMUG00000006775|UniProtKB=F7H3N8	Uncharacterized protein	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	TAS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DICPU|Gene=DICPUDRAFT_46519|UniProtKB=F0Z796	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	HUMAN|HGNC=7778|UniProtKB=Q14934	Nuclear factor of activated T-cells, cytoplasmic 4	ISS	12015605	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=98328|UniProtKB=P30875	Somatostatin receptor type 2	ISS	12441358	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P00054	Toll receptor signaling pathway	P01375	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IDA	7937853	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00048	PI3 kinase pathway	P01192	p110	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P02757	O-antigen biosynthesis	P03050	dTDP-4-dehydrorhamnose reductase	PSEAE|EnsemblGenome=PA4069|UniProtKB=Q9HWV9	Uncharacterized protein	ISS			PTHR10491:SF4	METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA
P00048	PI3 kinase pathway	P01192	p110	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DROME|FlyBase=FBgn0000489|UniProtKB=P16912	Protein kinase DC2	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	HUMAN|HGNC=1950|UniProtKB=P11229	Muscarinic acetylcholine receptor M1	ISS	12915051	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04376	5HT4 type receptor mediated signaling pathway	P04431	5HT transporter	HUMAN|HGNC=11050|UniProtKB=P31645	Sodium-dependent serotonin transporter	ISS	7681602	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P00057	Wnt signaling pathway	P01438	PP2A	HUMAN|HGNC=9312|UniProtKB=Q14738	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	IDA	12110603	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	ISS	12001934	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	TAS			PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00015	Circadian clock system	G01501	cry	MACMU|Ensembl=ENSMMUG00000002453|UniProtKB=F7HH05	Cryptochrome-2	ISS	10217146	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00181	SHP2	BOVIN|Ensembl=ENSBTAG00000002048|UniProtKB=F1N339	Tyrosine-protein phosphatase non-receptor type	ISS	7681589	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05924	AT1-R	CHICK|Ensembl=ENSGALG00000024000|UniProtKB=P79785	Type-1 angiotensin II receptor	RCA			PTHR24228:SF11	TYPE-1 ANGIOTENSIN II RECEPTOR
P00011	Blood coagulation	P00458	GP IIIa	BOVIN|Ensembl=ENSBTAG00000009987|UniProtKB=F1MTN1	Integrin beta	ISS	280842	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IC	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05730	Endogenous cannabinoid signaling	P05751	Galpha	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	YEAST|SGD=S000005694|UniProtKB=P13188	Glutamine--tRNA ligase	ISS			PTHR43097:SF4	GLUTAMINE--TRNA LIGASE-RELATED
P00059	p53 pathway	P04615	MTA2	MACMU|Ensembl=ENSMMUG00000018110|UniProtKB=F7EC89	Metastasis-associated 1-like 1	ISS	11099047	PubMed	PTHR10865:SF4	METASTASIS-ASSOCIATED PROTEIN MTA2
P02741	Flavin biosynthesis	P02937	3,4-Dihydroxy-2-butanone-4-phosphate synthase	METAC|EnsemblGenome=MA_0548|UniProtKB=Q8TT89	3,4-dihydroxy-2-butanone 4-phosphate synthase	ISS			PTHR21327:SF28	SUBFAMILY NOT NAMED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00029	Huntington disease	P00805	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01161	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000014576|UniProtKB=H2QLZ9	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=30035|UniProtKB=Q8WYR1	Phosphoinositide 3-kinase regulatory subunit 5	ISS	12507995	PubMed	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=7573|UniProtKB=P11055	Myosin-3	IC	10938134	PubMed	PTHR13140:SF427	MYOSIN-3
P00053	T cell activation	P01315	Calcineurin	MOUSE|MGI=MGI=107164|UniProtKB=P63328	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	ISS	12091710	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01305	Calmodulin	PHYIT|EnsemblGenome=PITG_06514|UniProtKB=D0N511	Calmodulin	ISS			PTHR23050:SF245	AT16150P-RELATED
P00010	B cell activation	P00391	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05916	Opioid prodynorphin pathway	P06000	vasopressin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00004	Alzheimer disease-presenilin pathway	P00111	C99	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00018	EGF receptor signaling pathway	P00546	GAP	HUMAN|HGNC=17294|UniProtKB=Q5VWQ8	Disabled homolog 2-interacting protein	ISS	14735459	gi	PTHR10194:SF26	DISABLED HOMOLOG 2-INTERACTING PROTEIN
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	DROME|FlyBase=FBgn0001991|UniProtKB=Q24270	Voltage-dependent calcium channel type D subunit alpha-1	ISS	8838325	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00034	Integrin signalling pathway	P00938	Cdc42	TAKRU|Ensembl=ENSTRUG00000008289|UniProtKB=H2T7U8	Uncharacterized protein	ISS	15723050	PubMed	PTHR24072:SF129	CDC42L PROTEIN
P04398	p53 pathway feedback loops 2	P04657	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	DROME|Gene=CG31075|UniProtKB=A0A0B4K6I6	Uncharacterized protein, isoform B	IC			PTHR11699:SF264	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-486685|UniProtKB=F6VT32	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00025	Hedgehog signaling pathway	P00692	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00047	PDGF signaling pathway	P01155	Jak	DANRE|ZFIN=ZDB-GENE-980526-142|UniProtKB=O12990	Tyrosine-protein kinase JAK1	ISS	11929133	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00047	PDGF signaling pathway	P01159	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	CHICK|Ensembl=ENSGALG00000003580|UniProtKB=Q90611	72 kDa type IV collagenase	TAS	12834808	PubMed	PTHR10201:SF29	72 KDA TYPE IV COLLAGENASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00023	General transcription regulation	P00660	RNA Polymerase II	NEUCR|EnsemblGenome=EFNCRG00000005070|UniProtKB=Q7S8Z5	DNA-directed RNA polymerase II polypeptide	ISS	11313498	PubMed	PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000014498|UniProtKB=F7GEI8	Uncharacterized protein	ISS	14624853	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00022	General transcription by RNA polymerase I	P00651	TAF-IA	BOVIN|Ensembl=ENSBTAG00000011339|UniProtKB=A7MAZ4	Transcription initiation factor TFIID subunit 8	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	HUMAN|HGNC=15963|UniProtKB=Q15825	Neuronal acetylcholine receptor subunit alpha-6	IC	85270494	PubMed	PTHR18945:SF82	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-6
P02754	Methylcitrate cycle	P03028	Aconitase	RAT|RGD=2019|UniProtKB=Q63270	Cytoplasmic aconitate hydratase	ISS			PTHR11670:SF32	CYTOPLASMIC ACONITATE HYDRATASE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MONDO|Ensembl=ENSMODG00000001196|UniProtKB=F7GH85	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CAEEL|WormBase=WBGene00000067|UniProtKB=O45815	ACTin	IDA	10974003	PubMed	PTHR11937:SF352	ACTIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P05915	Opioid proenkephalin pathway	P05994	G-protein	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	DANRE|ZFIN=ZDB-GENE-980526-332|UniProtKB=P51028	Protein Wnt-8a	TAS	8717036	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	TAKRU|Ensembl=ENSTRUG00000003589|UniProtKB=H2S7P7	Uncharacterized protein	ISS	11861492	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04393	Ras Pathway	P04560	AP1	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00053	T cell activation	P01312	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00021	FGF signaling pathway	P00627	ERK1-2	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00029	Huntington disease	P00774	Dynein complex	MOUSE|MGI=MGI=1859217|UniProtKB=Q9DCM4	Dynein light chain 4, axonemal	IPI	9454836	PubMed	PTHR11886:SF2	DYNEIN LIGHT CHAIN 4, AXONEMAL
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00020	FAS signaling pathway	P00615	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_206575|UniProtKB=E9FUX0	Guanine nucleotide binding protein, beta subunit	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00047	PDGF signaling pathway	P01165	SRF	MACMU|Ensembl=ENSMMUG00000000033|UniProtKB=F7G4D2	Uncharacterized protein	ISS	15170389	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	TAKRU|Ensembl=ENSTRUG00000011297|UniProtKB=H2TV18	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00047	PDGF signaling pathway	P01154	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	SCLS1|EnsemblGenome=SS1G_05445|UniProtKB=A7EJF2	Mitogen-activated protein kinase	ISS	98445436	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P02749	Leucine biosynthesis	P03001	3-Isopropylmalate dehydrogenase	SULSO|EnsemblGenome=SSO0723|UniProtKB=Q9UXB2	3-isopropylmalate dehydrogenase	ISS			PTHR11835:SF48	HOMOISOCITRATE DEHYDROGENASE, MITOCHONDRIAL
P00005	Angiogenesis	P00237	FRP	MACMU|Ensembl=ENSMMUG00000014396|UniProtKB=F7BWZ1	Secreted frizzled-related protein 3	ISS	9118218	PubMed	PTHR11309:SF97	SECRETED FRIZZLED-RELATED PROTEIN 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00034	Integrin signalling pathway	P00911	B-Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	12068308	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	TAS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	PANTR|Ensembl=ENSPTRG00000006510|UniProtKB=H2Q8K1	Presenilin	ISS	12736250	PubMed	PTHR10202:SF18	PRESENILIN-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00236	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00053	T cell activation	P01337	B7	HUMAN|HGNC=1705|UniProtKB=P42081	T-lymphocyte activation antigen CD86	ISS	7694363	PubMed	PTHR25466:SF2	T-LYMPHOCYTE ACTIVATION ANTIGEN CD86
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	PANTR|Ensembl=ENSPTRG00000004326|UniProtKB=H2Q4V0	Uncharacterized protein	ISS			PTHR44107:SF3	DOWN SYNDROME CELL ADHESION MOLECULE-LIKE PROTEIN 1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CHICK|Gene=CHRNA5|UniProtKB=P26152	Neuronal acetylcholine receptor subunit alpha-5	IC	85270494	PubMed	PTHR18945:SF76	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	SYNY3|EnsemblGenome=BAA10756|UniProtKB=P54386	NADP-specific glutamate dehydrogenase	ISS			PTHR11606:SF13	GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01413	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00009	Axon guidance mediated by netrin	P00363	PI3K	DROME|FlyBase=FBgn0015278|UniProtKB=Q7K3H0	LD28067p	ISS	7937853	PubMed	PTHR10048:SF64	LD28067P
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BOVIN|Ensembl=ENSBTAG00000014614|UniProtKB=P62739	Actin, aortic smooth muscle	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00053	T cell activation	P01318	PKC-theta	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	MOUSE|MGI=MGI=96433|UniProtKB=Q60751	Insulin-like growth factor 1 receptor	ISS	249616	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	MACMU|Ensembl=ENSMMUG00000001387|UniProtKB=F7D0B4	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=24667|UniProtKB=Q8TD08	Mitogen-activated protein kinase 15	IDA	11875070	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00021	FGF signaling pathway	P00629	PP2A	RAT|RGD=6503746|UniProtKB=Q80W83	Protein LOC100909468	ISS	11531413	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01020	NSF	DROME|FlyBase=FBgn0000346|UniProtKB=P46461	Vesicle-fusing ATPase 1	ISS	11348590	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00230	PDGFR	HUMAN|HGNC=8804|UniProtKB=P09619	Platelet-derived growth factor receptor beta	IDA	12374780	PubMed	PTHR24416:SF53	PLATELET-DERIVED GROWTH FACTOR RECEPTOR BETA
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	HUMAN|HGNC=5964|UniProtKB=Q13651	Interleukin-10 receptor subunit alpha	IPI	8407942	PubMed	PTHR20859:SF43	INTERLEUKIN-10 RECEPTOR SUBUNIT ALPHA
P00013	Cell cycle	P00480	Proteasome	RAT|RGD=1311470|UniProtKB=Q5U2S7	Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 3	ISS	2568889	PubMed	PTHR10758:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3
P00057	Wnt signaling pathway	P01440	Cadherin	CANLF|Ensembl=ENSCAFG00000006229|UniProtKB=E2QX93	Uncharacterized protein	ISS	8120095	PubMed	PTHR43912:SF3	PROTOCADHERIN-1
P04393	Ras Pathway	P04559	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00807	Actin	DANRE|ZFIN=ZDB-GENE-050417-267|UniProtKB=F1QUN8	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF263	ACTIN
P04393	Ras Pathway	P04551	RalGDS	PANTR|Ensembl=ENSPTRG00000001768|UniProtKB=H2Q0R8	Uncharacterized protein	ISS			PTHR23113:SF199	RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	XENTR|Xenbase=XB-GENE-977853|UniProtKB=F7EBE7	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00628	JNK1-3	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000012036|UniProtKB=F7ALP1	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00049	Parkinson disease	P01236	Casein kinase II	ORYSJ|EnsemblGenome=OS03G0763000|UniProtKB=Q8W5G9	Casein kinase II, alpha chain, putative, expressed	IDA	10617630	PubMed	PTHR24054:SF33	CASEIN KINASE II SUBUNIT ALPHA, CHLOROPLASTIC
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	TAS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00029	Huntington disease	P00774	Dynein complex	HUMAN|HGNC=2963|UniProtKB=O14576	Cytoplasmic dynein 1 intermediate chain 1	IPI	9454836	PubMed	PTHR12442:SF34	CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN 1
P00054	Toll receptor signaling pathway	P01375	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00165	E-cadherin N-terminal fragment	RAT|RGD=621089|UniProtKB=F1LMI3	Cadherin 3, type 1, P-cadherin (Placental)	ISS	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=97440|UniProtKB=P35377	Nociceptin receptor	IDA	11259487	PubMed	PTHR24229:SF11	NOCICEPTIN RECEPTOR
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CAEEL|WormBase=WBGene00003171|UniProtKB=P12456	Tubulin beta-1 chain	ISS	9454836	PubMed	PTHR11588:SF255	TUBA7L PROTEIN
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-486685|UniProtKB=F6VT32	Protein kinase C	ISS	11880265	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000001014|UniProtKB=A5PKJ4	Mitogen-activated protein kinase 7	ISS	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00059	p53 pathway	G01575	GADD45	MOUSE|MGI=MGI=107799|UniProtKB=P48316	Growth arrest and DNA damage-inducible protein GADD45 alpha	IGI	7509226	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P00021	FGF signaling pathway	P00641	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00049	Parkinson disease	P01211	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IDA	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00021	FGF signaling pathway	P00647	SHP2	CHICK|Ensembl=ENSGALG00000004821|UniProtKB=Q90687	Tyrosine-protein phosphatase non-receptor type 11	ISS	14525967	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00059	p53 pathway	G04694	p110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00385	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	10540223	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00021	FGF signaling pathway	P00640	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	IGI	14526383	PubMed	PTHR10048:SF14	PI-3 KINASE
P00021	FGF signaling pathway	P00624	14-3-3	SCHMA|EnsemblGenome=Smp_002410|UniProtKB=Q95W36	14-3-3 epsilon 2	IGI	22057984	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00006	Apoptosis signaling pathway	P00269	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Ensembl=ENSGALG00000011086|UniProtKB=P68139	Actin, alpha skeletal muscle	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00009	Axon guidance mediated by netrin	P00364	cdc42	TAKRU|Ensembl=ENSTRUG00000008289|UniProtKB=H2T7U8	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF129	CDC42L PROTEIN
P00057	Wnt signaling pathway	P01435	SWI/SNF	CHICK|Ensembl=ENSGALG00000009913|UniProtKB=E1C0M8	Uncharacterized protein	ISS	11532957	PubMed	PTHR10799:SF887	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=2136018|UniProtKB=Q9QYS1	Protein Wnt-16	IDA	8717036	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P00053	T cell activation	P01320	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	RAT|RGD=2518|UniProtKB=P18901	D(1A) dopamine receptor	ISS	11248120	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00010	B cell activation	P00379	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANAL|CGD=CAL0068551|UniProtKB=Q5AAR9	Phosphatidylinositol 3-kinase	TAS	20330542	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01435	SWI/SNF	BOVIN|Ensembl=ENSBTAG00000002292|UniProtKB=F1N166	Uncharacterized protein	ISS	11532957	PubMed	PTHR10799:SF819	GLOBAL TRANSCRIPTION ACTIVATOR SNF2L1-RELATED
P02731	Biotin biosynthesis	P02857	Biotin synthase	LEPIN|EnsemblGenome=LA_2143|UniProtKB=Q8F498	Biotin synthase	ISS			PTHR22976:SF1	BIOTIN SYNTHASE, MITOCHONDRIAL
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000001014|UniProtKB=A5PKJ4	Mitogen-activated protein kinase 7	ISS	12912994	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00048	PI3 kinase pathway	P01192	p110	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	CAEEL|WormBase=WBGene00006932|UniProtKB=Q9TXI7	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IDA	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00019	Endothelin signaling pathway	P00590	IP3 R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01457	GBeta	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00034	Integrin signalling pathway	P00912	Arp2/3	RAT|RGD=1311985|UniProtKB=B2GV73	Actin-related protein 2/3 complex subunit 3	ISS	12473693	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	BOVIN|Ensembl=ENSBTAG00000020742|UniProtKB=F1MBL4	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF79	FRIZZLED-9
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	DROME|FlyBase=FBgn0032151|UniProtKB=Q7KTF8	Nicotinic acetylcholine receptor alpha6, isoform E	IC	11404397	PubMed	PTHR18945:SF763	NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA6, ISOFORM E
P00059	p53 pathway	G04694	p110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00005	Angiogenesis	P00216	Caspase 9	HUMAN|HGNC=1511|UniProtKB=P55211	Caspase-9	IDA	8663294	PubMed	PTHR10454:SF157	CASPASE-9
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01413	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00561	STAT	CHICK|Ensembl=ENSGALG00000003267|UniProtKB=Q6DV79	Signal transducer and activator of transcription 3	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00025	Hedgehog signaling pathway	P00682	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	TAS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00639	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	7680960	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00470	F-actin	CRYNJ|EnsemblGenome=CNA04650|UniProtKB=Q5KP06	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04393	Ras Pathway	P04547	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	IDA	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04397	p53 pathway by glucose deprivation	P04641	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	MOUSE|MGI=MGI=1926879|UniProtKB=Q9EQH4	Transcription initiation factor TFIID subunit 8	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00047	PDGF signaling pathway	P01163	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	3136397	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01435	SWI/SNF	PANTR|Ensembl=ENSPTRG00000000388|UniProtKB=H2PYE4	Uncharacterized protein	ISS	11532957	PubMed	PTHR12656:SF12	AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 1A
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	PANTR|Ensembl=ENSPTRG00000023608|UniProtKB=H2QZZ2	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P04393	Ras Pathway	P04578	Rho	CHICK|Ensembl=ENSGALG00000003806|UniProtKB=O93467	GTP-binding protein	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P02747	Histidine biosynthesis	P02991	Histidinephosphate aminotransferase	HALSA|EnsemblGenome=VNG_1582G|UniProtKB=Q9HPL0	Histidinol-phosphate transaminase	ISS			PTHR42885:SF1	SUBFAMILY NOT NAMED
P04377	Beta1 adrenergic receptor signaling pathway	P04433	Beta1	BOVIN|Gene=ADRB1|UniProtKB=Q9TT96	Beta-1 adrenergic receptor	ISS	12730078	PubMed	PTHR24248:SF54	BETA-1 ADRENERGIC RECEPTOR
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MOUSE|MGI=MGI=99673|UniProtKB=P84309	Adenylate cyclase type 5	ISS	94139935	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	IDA	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	G01540	BDNF	MOUSE|MGI=MGI=88145|UniProtKB=P21237	Brain-derived neurotrophic factor	ISS	12117585	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CAEEL|WormBase=WBGene00017277|UniProtKB=Q19243	Mitogen-activated protein kinase	ISS			PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00053	T cell activation	P01319	PAK	BOVIN|Ensembl=ENSBTAG00000010191|UniProtKB=Q08E52	Serine/threonine-protein kinase PAK 1	ISS	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00049	Parkinson disease	P01211	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00219	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	CHICK|Gene=CHRNA2|UniProtKB=P09480	Neuronal acetylcholine receptor subunit alpha-2	IC			PTHR18945:SF757	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-2
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00015	Circadian clock system	P00501	Clock	RAT|RGD=620271|UniProtKB=Q9WVS9	Circadian locomoter output cycles protein kaput	ISS	10198158	PubMed	PTHR23042:SF2	CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT
P02746	Heme biosynthesis	P02972	Ferrochelatase	BOVIN|Ensembl=ENSBTAG00000006393|UniProtKB=P22600	Ferrochelatase, mitochondrial	ISS			PTHR11108:SF1	FERROCHELATASE, MITOCHONDRIAL
P05918	p38 MAPK pathway	P06017	MNK2	HUMAN|HGNC=7111|UniProtKB=Q9HBH9	MAP kinase-interacting serine/threonine-protein kinase 2	IDA	9155017	PubMed	PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P02742	Tetrahydrofolate biosynthesis	P02951	GTP cyclohydrolase	SULSO|EnsemblGenome=SSO0364|UniProtKB=Q980E8	GTP cyclohydrolase 1	ISS			PTHR11109:SF0	GTP CYCLOHYDROLASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00006	Apoptosis signaling pathway	P00260	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04547	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00046	Oxidative stress response	P01131	MKP5	RAT|RGD=1310844|UniProtKB=D3ZBG7	Dual specificity phosphatase 10 (Predicted)	ISS	11856337	PubMed	PTHR10159:SF299	DUAL SPECIFICITY PROTEIN PHOSPHATASE 10
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00029	Huntington disease	P00811	Arp2/3 complex	DANRE|ZFIN=ZDB-GENE-040116-1|UniProtKB=Q7ZUQ0	Actin related protein 2/3 complex, subunit 1A	ISS	12932731	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00034	Integrin signalling pathway	P00920	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00015	Circadian clock system	G01501	cry	CANLF|Ensembl=ENSCAFG00000001797|UniProtKB=E2RMX4	Uncharacterized protein	ISS	14507900	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00973	PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00006	Apoptosis signaling pathway	P00321	HSP70	PHYIT|EnsemblGenome=PITG_11244|UniProtKB=D0NGJ2	Heat shock 70 kDa protein	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00021	FGF signaling pathway	P00645	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	20010089	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	MACMU|Ensembl=ENSMMUG00000017022|UniProtKB=F7HQZ9	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Ensembl=ENSGALG00000028749|UniProtKB=Q5ZMQ2	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P05731	GABA-B receptor II signaling	P05752	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	RCA	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00005	Angiogenesis	P00246	Ang-2	CHICK|Ensembl=ENSGALG00000016330|UniProtKB=Q9DER2	Angiopoietin-2A	ISS			PTHR19143:SF199	ANGIOPOIETIN-2
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	PANTR|Ensembl=ENSPTRG00000004964|UniProtKB=H2Q5Y6	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00011	Blood coagulation	P00429	PN2	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	ISS	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CAEEL|WormBase=WBGene00001187|UniProtKB=Q8MQA1	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P02728	Arginine biosynthesis	P02846	Ornithine carbamoyl transferase	BOVIN|Gene=OTC|UniProtKB=Q9N1U7	Ornithine carbamoyltransferase, mitochondrial	ISS			PTHR11405:SF1	ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL
P00034	Integrin signalling pathway	P00927	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	10891487	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00052	TGF-beta signaling pathway	P01275	P38	CAEEL|WormBase=WBGene00004055|UniProtKB=Q17446	Mitogen-activated protein kinase pmk-1	TAS	11707292	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	CHICK|Ensembl=ENSGALG00000007129|UniProtKB=Q9DD46	Aldehyde dehydrogenase	IC			PTHR11699:SF209	ALDEHYDE DEHYDROGENASE FAMILY 1 MEMBER A3
P00038	JAK/STAT signaling pathway	P01034	Jak	PANTR|Ensembl=ENSPTRG00000000825|UniProtKB=H2PZ66	Tyrosine-protein kinase	ISS	9637709	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00018	EGF receptor signaling pathway	P00558	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00005	Angiogenesis	P00231	HSP27	DANRE|ZFIN=ZDB-GENE-991119-2|UniProtKB=Q9PUR2	Alpha b crystallin	ISS			PTHR11527:SF37	ALPHA-CRYSTALLIN B CHAIN
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DROME|FlyBase=FBgn0000489|UniProtKB=P16912	Protein kinase DC2	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CHICK|Ensembl=ENSGALG00000009356|UniProtKB=F1P0N0	Uncharacterized protein	IGI	10485843	PubMed	PTHR10005:SF3	SKI-LIKE PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00049	Parkinson disease	P01211	ERK	MOUSE|MGI=MGI=1346347|UniProtKB=Q9WVS8	Mitogen-activated protein kinase 7	IDA	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00805	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	CHICK|Ensembl=ENSGALG00000010529|UniProtKB=O93345	Lymphiod enhancer binding factor 1	TAS	9039917	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	HUMAN|HGNC=1074|UniProtKB=P18075	Bone morphogenetic protein 7	TAS	9759503	PubMed	PTHR11848:SF135	BONE MORPHOGENETIC PROTEIN 7
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00048	PI3 kinase pathway	P01205	NOS	HUMAN|HGNC=7876|UniProtKB=P29474	Nitric oxide synthase, endothelial	ISS	10435050	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00049	Parkinson disease	P01242	Casein kinase I	ARATH|TAIR=AT3G23340|UniProtKB=Q9LW62	AT3g23340/MLM24_21	IDA	11437445	PubMed	PTHR11909:SF178	CASEIN KINASE 1-LIKE PROTEIN 8
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02761	Pantothenate biosynthesis	P03068	Pantoate-beta-alanine ligase	STRCO|EnsemblGenome=CAD55315|UniProtKB=Q9X844	Pantothenate synthetase	ISS			PTHR21299:SF1	PANTOATE--BETA-ALANINE LIGASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000019361|UniProtKB=H2QUV3	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00005	Angiogenesis	P00203	Erk	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00302	ATF	RAT|RGD=620218|UniProtKB=P15337	Cyclic AMP-responsive element-binding protein 1	ISS	1354612	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	DANRE|ZFIN=ZDB-GENE-991119-4|UniProtKB=Q9W6T7	Presenilin-1	TAS	12101103	PubMed	PTHR10202:SF18	PRESENILIN-1
P00029	Huntington disease	P00811	Arp2/3 complex	PANTR|Ensembl=ENSPTRG00000033819|UniProtKB=H2QV00	Actin related protein 2/3 complex, subunit 1A, 41kDa	ISS	12963527	gi	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00052	TGF-beta signaling pathway	P01288	FKBP12	CRYNJ|Gene=CNB01800|UniProtKB=P0CP94	FK506-binding protein 1	ISS			PTHR10516:SF341	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE
P02751	Lysine biosynthesis	P03009	Aspartokinase	THEMA|EnsemblGenome=TM_0547|UniProtKB=Q9WZ17	Aspartokinase II	ISS			PTHR21499:SF3	ASPARTOKINASE
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00973	PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	XENTR|Xenbase=XB-GENE-999035|UniProtKB=F7CEB1	Uncharacterized protein	ISS	1722329	PubMed	PTHR42884:SF1	FURIN
P00012	Cadherin signaling pathway	P00471	Cadherin	BOVIN|Ensembl=ENSBTAG00000019340|UniProtKB=F1MMW5	Uncharacterized protein	ISS	8120095	PubMed	PTHR43912:SF5	PROTOCADHERIN-9
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IDA	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01173	STAT	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P06959	CCKR signaling map	P07213	c-RAF / RAF1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	RCA	21810446	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00029	Huntington disease	P00775	Rac	RAT|RGD=621626|UniProtKB=Q9JJL4	Rho-related GTP-binding protein RhoQ	ISS	12932731	PubMed	PTHR24072:SF13	RHO-RELATED GTP-BINDING PROTEIN RHOQ
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MONDO|Ensembl=ENSMODG00000020977|UniProtKB=F6S5B1	Uncharacterized protein (Fragment)	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	SCHMA|EnsemblGenome=Smp_020170|UniProtKB=G4V8E3	Voltage-dependent calcium channel (Fragment)	ISS	8386525	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	RAT|RGD=2343|UniProtKB=P08483	Muscarinic acetylcholine receptor M3	IDA	11166329	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MOUSE|MGI=MGI=104558|UniProtKB=P18653	Ribosomal protein S6 kinase alpha-1	ISS	6755374	gi	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00057	Wnt signaling pathway	P01468	APC	HUMAN|HGNC=583|UniProtKB=P25054	Adenomatous polyposis coli protein	IDA	8259518	PubMed	PTHR12607:SF11	ADENOMATOUS POLYPOSIS COLI PROTEIN
P00006	Apoptosis signaling pathway	P00269	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00049	Parkinson disease	P01219	SAPK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00477	GSK3beta	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00045	Notch signaling pathway	P01120	NIcs	MOUSE|MGI=MGI=99460|UniProtKB=Q61982	Neurogenic locus notch homolog protein 3	IC	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00203	Erk	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	RAT|RGD=2410|UniProtKB=Q62952	Dihydropyrimidinase-related protein 3	ISS	3122041	gi	PTHR11647:SF57	DIHYDROPYRIMIDINASE-RELATED PROTEIN 3
P00054	Toll receptor signaling pathway	P01360	IKKbeta	CANLF|Ensembl=ENSCAFG00000005526|UniProtKB=E2RKR0	Uncharacterized protein	ISS	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00019	Endothelin signaling pathway	P00577	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IGI	96009592	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00165	E-cadherin N-terminal fragment	MOUSE|MGI=MGI=88354|UniProtKB=P09803	Cadherin-1	TAS	11953314	PubMed	PTHR24027:SF319	CADHERIN-1
P04396	Vitamin D metabolism and pathway	P04607	FDX	MACMU|Ensembl=ENSMMUG00000002110|UniProtKB=F6UXB5	Uncharacterized protein	ISS	2969697	PubMed	PTHR23426:SF26	ADRENODOXIN, MITOCHONDRIAL
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	RAT|RGD=628852|UniProtKB=Q02294	Voltage-dependent N-type calcium channel subunit alpha-1B	IDA	15079861	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00059	p53 pathway	G04694	p110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05731	GABA-B receptor II signaling	P05760	AC	RAT|RGD=1309318|UniProtKB=D4A3N4	Adenylate cyclase 1 (Predicted)	ISS	89298382	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P00036	Interleukin signaling pathway	P00971	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12186904	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12880387	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	MACMU|Gene=CXCL8|UniProtKB=P67813	Interleukin-8	ISS	124361	gi	PTHR10179:SF70	INTERLEUKIN-8
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02744	Fructose galactose metabolism	P02965	UDP Glucose 4 epimerase	MOUSE|MGI=MGI=1921496|UniProtKB=Q8R059	UDP-glucose 4-epimerase	RCA			PTHR43725:SF8	UDP-GLUCOSE 4-EPIMERASE
P00049	Parkinson disease	P01230	Src kinase	RAT|RGD=1308800|UniProtKB=P32577	Tyrosine-protein kinase CSK	ISS	12665526	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00046	Oxidative stress response	P01135	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	TAS	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TRIAD|EnsemblGenome=TriadG49626|UniProtKB=B3RKR4	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P06664	Gonadotropin-releasing hormone receptor pathway	P06738	PLA2	MOUSE|MGI=MGI=1859152|UniProtKB=P97819	85/88 kDa calcium-independent phospholipase A2	RCA			PTHR24139:SF34	85/88 KDA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-RELATED
P00059	p53 pathway	G04694	p110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01451	Galpha	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	IDA	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00020	FAS signaling pathway	P00615	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04376	5HT4 type receptor mediated signaling pathway	P04426	K+ channel	PANTR|Ensembl=ENSPTRG00000020614|UniProtKB=H2QWR7	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	MOUSE|MGI=MGI=88296|UniProtKB=O55017	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	11976940	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P05731	GABA-B receptor II signaling	P05760	AC	BOVIN|Ensembl=ENSBTAG00000014600|UniProtKB=E1BQ12	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00045	Notch signaling pathway	P01103	Next	RAT|RGD=2937|UniProtKB=Q63722	Protein jagged-1	IDA	7697721	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00053	T cell activation	P01311	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CAEBR|Gene=CBG18256|UniProtKB=A8XS95	Protein CBR-ACT-5	ISS	14684598	PubMed	PTHR11937:SF352	ACTIN
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05913	Enkephalin release	P05972	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04552	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00624	14-3-3	ARATH|TAIR=AT5G10450|UniProtKB=P48349	14-3-3-like protein GF14 lambda	ISS	10407019	PubMed	PTHR18860:SF27	14-3-3-LIKE PROTEIN GF14 LAMBDA
P00030	Hypoxia response via HIF activation	P00819	AKT	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	TAS	12089061	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01307	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	ECOLI|EcoGene=EG10661|UniProtKB=P69924	Ribonucleoside-diphosphate reductase 1 subunit beta	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00049	Parkinson disease	P01236	Casein kinase II	ARATH|TAIR=AT2G23080|UniProtKB=O64817	Probable casein kinase II subunit alpha	IDA	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	TAS	2837282	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00025	Hedgehog signaling pathway	P00692	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00049	Parkinson disease	P01242	Casein kinase I	TAKRU|Ensembl=ENSTRUG00000000304|UniProtKB=H2RKM1	Uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P05915	Opioid proenkephalin pathway	P05990	K+ channel	PANTR|Ensembl=ENSPTRG00000020614|UniProtKB=H2QWR7	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00010	B cell activation	P00385	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00923	Arf1	DANRE|ZFIN=ZDB-GENE-040122-4|UniProtKB=Q6NYD8	ADP-ribosylation factor 2	ISS	11752622	PubMed	PTHR11711:SF299	ADP-RIBOSYLATION FACTOR 2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P06959	CCKR signaling map	P07215	G17	HUMAN|HGNC=4164|UniProtKB=P01350	Gastrin	RCA	18184106	PubMed	PTHR19309:SF0	GASTRIN
P00012	Cadherin signaling pathway	P00477	GSK3beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	HUMAN|HGNC=4041|UniProtKB=Q9NPG1	Frizzled-3	TAS	11212302	PubMed	PTHR11309:SF22	FRIZZLED-3
P02759	Pyridoxal-5-phosphate biosynthesis	P03058	Phosphohydroxythreonine aminotransferase	XENTR|Xenbase=XB-GENE-1016013|UniProtKB=A0JPC0	Phosphoserine aminotransferase	ISS			PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	RAT|RGD=1308057|UniProtKB=F1M077	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00034	Integrin signalling pathway	P00919	Arf6	MACMU|Ensembl=ENSMMUG00000015642|UniProtKB=F6RLV0	ADP-ribosylation factor 6	ISS	11752622	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P04395	Vasopressin synthesis	P04594	Neurophysin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02916	dTMP kinase	STRCO|Gene=CAB38479|UniProtKB=Q9X908	dTMP kinase	ISS			PTHR10344:SF1	THYMIDYLATE KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=268|UniProtKB=P0DMS8	Adenosine receptor A3	IDA	11781138	PubMed	PTHR24246:SF2	ADENOSINE RECEPTOR A3
P00019	Endothelin signaling pathway	P00590	IP3 R	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	IGI	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BOVIN|Ensembl=ENSBTAG00000008097|UniProtKB=A4D7S0	Protein Wnt-2	ISS	8717036	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01452	NFAT	PANTR|Ensembl=ENSPTRG00000013628|UniProtKB=H2R4F5	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00034	Integrin signalling pathway	P00922	Collagen	HUMAN|HGNC=22986|UniProtKB=Q8IZC6	Collagen alpha-1(XXVII) chain	IDA	10778855	PubMed	PTHR24023:SF844	COLLAGEN ALPHA-1 XXVII  CHAIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	BOVIN|Ensembl=ENSBTAG00000000347|UniProtKB=Q1RMI2	Ras homolog gene family, member G (Rho G)	ISS			PTHR24072:SF158	RHO-RELATED GTP-BINDING PROTEIN RHOG
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IC	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00023	General transcription regulation	P00670	TBP	CHICK|Ensembl=ENSGALG00000013981|UniProtKB=Q9YGV8	TATA box-binding protein-like protein 1	IPI	600075	OMIM	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00012	Cadherin signaling pathway	P00477	GSK3beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00925	MEK	MACMU|Ensembl=ENSMMUG00000019842|UniProtKB=F7FU91	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000018563|UniProtKB=F6YMF6	Uncharacterized protein	ISS	12441358	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P02769	Purine metabolism	P03116	Xanthine Oxidase	BOVIN|Gene=XDH|UniProtKB=P80457	Xanthine dehydrogenase/oxidase	NAS	4336760	gi	PTHR11908:SF80	XANTHINE DEHYDROGENASE/OXIDASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	YEAST|SGD=S000003387|UniProtKB=P32582	Cystathionine beta-synthase	ISS			PTHR10314:SF8	CYSTATHIONINE BETA-SYNTHASE-RELATED
P00018	EGF receptor signaling pathway	P00539	14-3-3	MACMU|Ensembl=ENSMMUG00000006489|UniProtKB=F7EFF6	14-3-3 protein zeta/delta	ISS	92283271	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00007	Axon guidance mediated by semaphorins	P00337	Sema3A	CHICK|Gene=SEMA3A|UniProtKB=Q90607	Semaphorin-3A	IDA	8402908	PubMed	PTHR11036:SF23	SEMAPHORIN-3A
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000001962|UniProtKB=F6V2H6	Uncharacterized protein	ISS	8444355	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00014	Cholesterol biosynthesis	P00493	Geranyl trans-transferase	DICDI|dictyBase=DDB_G0278735|UniProtKB=Q9NH03	Farnesyl diphosphate synthase	ISS	O64905	SPACC	PTHR11525:SF0	FARNESYL PYROPHOSPHATE SYNTHASE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CHICK|Ensembl=ENSGALG00000015835|UniProtKB=F1NZT2	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	CAEEL|WormBase=WBGene00000069|UniProtKB=O16880	Adenylyl CYclase	IGI	98393546	PubMed	PTHR11920:SF352	ADENYLATE CYCLASE TYPE 2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00057	Wnt signaling pathway	P01446	Calcineurin	XENTR|Xenbase=XB-GENE-952299|UniProtKB=B0BLZ8	Serine/threonine-protein phosphatase	ISS	12091710	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00805	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00025	Hedgehog signaling pathway	P00688	Hedgehog	DANRE|ZFIN=ZDB-GENE-980526-166|UniProtKB=Q92008	Sonic hedgehog protein A	IDA	8269519	PubMed	PTHR11889:SF83	SONIC HEDGEHOG PROTEIN A-RELATED
P00029	Huntington disease	P00777	CBP	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00056	VEGF signaling pathway	P01411	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P00018	EGF receptor signaling pathway	P00551	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00371	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	TAS	10395542	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	IXOSC|EnsemblGenome=ISCW014549|UniProtKB=B7QGY5	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00907	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	DROME|FlyBase=FBgn0012036|UniProtKB=Q9VLC5	Aldehyde dehydrogenase	IC			PTHR11699:SF265	ALDEHYDE DEHYDROGENASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	DAPPU|EnsemblGenome=DAPPUDRAFT_206575|UniProtKB=E9FUX0	Guanine nucleotide binding protein, beta subunit	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P02738	De novo purine biosynthesis	P02898	Phosphoribosylformylglycinamide  synthase	STRCO|EnsemblGenome=CAB56359|UniProtKB=Q9RKK5	Phosphoribosylformylglycinamidine synthase subunit PurL	ISS			PTHR43555:SF1	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000009085|UniProtKB=H2RDQ2	Uncharacterized protein	ISS	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	CANAL|EnsemblGenome=CaO19.1760|UniProtKB=Q59XU5	Ras-like protein 1	ISS	99445463	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00056	VEGF signaling pathway	P01401	HIF-1	PANTR|Ensembl=ENSPTRG00000006419|UniProtKB=H2Q8F3	Uncharacterized protein	ISS	9606183	PubMed	PTHR23043:SF7	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	MONDO|Ensembl=ENSMODG00000020977|UniProtKB=F6S5B1	Uncharacterized protein (Fragment)	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00036	Interleukin signaling pathway	P00965	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IC	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00645	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	10891487	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00057	Wnt signaling pathway	P01430	p53	BOVIN|Ensembl=ENSBTAG00000001069|UniProtKB=P67939	Cellular tumor antigen p53	IDA	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00016	Cytoskeletal regulation by Rho GTPase	P00507	Rho	YEAST|SGD=S000006369|UniProtKB=P06780	GTP-binding protein RHO1	ISS			PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	HUMAN|HGNC=4595|UniProtKB=Q14832	Metabotropic glutamate receptor 3	ISS	9407094	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Ensembl=ENSGALG00000014620|UniProtKB=F1N8P3	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00055	Transcription regulation by bZIP transcription factor	P01398	TFIIEalpha	MOUSE|MGI=MGI=1921447|UniProtKB=Q9D0D5	General transcription factor IIE subunit 1	ISS	92065982	PubMed	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00054	Toll receptor signaling pathway	P01374	IRF3	MOUSE|MGI=MGI=1859179|UniProtKB=P70671	Interferon regulatory factor 3	ISS			PTHR11949:SF1	INTERFERON REGULATORY FACTOR 3
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	176910	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	BOVIN|Ensembl=ENSBTAG00000020887|UniProtKB=F1MP22	Uncharacterized protein	ISS	11976940	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P05913	Enkephalin release	P05974	G-Protein (i)	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	IC	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00056	VEGF signaling pathway	P01417	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01395	TFIIE	HUMAN|HGNC=4651|UniProtKB=P29084	Transcription initiation factor IIE subunit beta	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00017	DNA replication	P00527	Histones	BATDJ|Gene=BATDEDRAFT_20154|UniProtKB=F4P7A5	Histone H3	ISS	12413958	PubMed	PTHR11426:SF169	HISTONE H3
P00045	Notch signaling pathway	P01104	Serrate	DANRE|ZFIN=ZDB-GENE-011128-4|UniProtKB=Q90Y54	Protein jagged-1b	ISS			PTHR44097:SF3	PROTEIN JAGGED-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	IDA	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00020	FAS signaling pathway	P00596	Caspase6	XENTR|Xenbase=XB-GENE-482797|UniProtKB=F6R1R1	Uncharacterized protein	ISS	11463840	PubMed	PTHR10454:SF164	CASPASE-6
P00047	PDGF signaling pathway	P01160	IP3 receptor	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00048	PI3 kinase pathway	P01189	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MACMU|Ensembl=ENSMMUG00000000605|UniProtKB=F6Y8V8	Uncharacterized protein	ISS	12356903	PubMed	PTHR10845:SF11	AXIN-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	CANLF|Ensembl=ENSCAFG00000009282|UniProtKB=E2RLD6	Uncharacterized protein	RCA			PTHR22952:SF24	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 1
P02736	Coenzyme A biosynthesis	P02885	Pantothenate kinase	BOVIN|Ensembl=ENSBTAG00000007920|UniProtKB=F1MX42	Uncharacterized protein	ISS			PTHR12280:SF25	PANTOTHENATE KINASE 2, MITOCHONDRIAL
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IDA	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	SULSO|EnsemblGenome=SSO0230|UniProtKB=Q980Q7	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00009	Axon guidance mediated by netrin	P00359	NFAT	HUMAN|HGNC=7776|UniProtKB=Q13469	Nuclear factor of activated T-cells, cytoplasmic 2	IDA	12015605	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00047	PDGF signaling pathway	P01153	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00021	FGF signaling pathway	P00629	PP2A	CANLF|Ensembl=ENSCAFG00000015787|UniProtKB=F6V7D9	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00036	Interleukin signaling pathway	P00990	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04609	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00469	Fer	RAT|RGD=1306273|UniProtKB=P09760	Tyrosine-protein kinase Fer	ISS	9742093	PubMed	PTHR24418:SF227	TYROSINE-PROTEIN KINASE FER
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MOUSE|MGI=MGI=102705|UniProtKB=P63213	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IDA	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00034	Integrin signalling pathway	P00939	Fibronectin	PANTR|Ensembl=ENSPTRG00000012892|UniProtKB=H2R1A9	Uncharacterized protein	ISS	12970173	PubMed	PTHR19143:SF267	FIBRONECTIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CAEEL|WormBase=WBGene00003514|UniProtKB=P12845	Myosin-2	IC			PTHR13140:SF473	MYOSIN-2
P00059	p53 pathway	G04700	PAI	CANLF|Ensembl=ENSCAFG00000013909|UniProtKB=F1PUI4	Uncharacterized protein	ISS	10692390	PubMed	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00029	Huntington disease	P00810	GAPDH	MOUSE|MGI=MGI=3779717|UniProtKB=D3YYI5	Glyceraldehyde-3-phosphate dehydrogenase	IPI	8612237	PubMed	PTHR10836:SF51	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00010	B cell activation	P00381	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00539	14-3-3	MACMU|Ensembl=ENSMMUG00000006489|UniProtKB=F7EFF6	14-3-3 protein zeta/delta	ISS	12615066	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00019	Endothelin signaling pathway	P00585	ECE1-3	MOUSE|MGI=MGI=1343461|UniProtKB=Q9JMI0	Endothelin-converting enzyme-like 1	ISS	9931490	PubMed	PTHR11733:SF195	ENDOTHELIN-CONVERTING ENZYME-LIKE 1
P05916	Opioid prodynorphin pathway	P05998	Kappa Receptor	HUMAN|HGNC=8154|UniProtKB=P41145	Kappa-type opioid receptor	RCA	11259487	PubMed	PTHR24229:SF1	KAPPA-TYPE OPIOID RECEPTOR
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	MACMU|Ensembl=ENSMMUG00000030101|UniProtKB=F7GWL3	Uncharacterized protein	ISS			PTHR23359:SF58	ADENYLATE KINASE 4, MITOCHONDRIAL
P00054	Toll receptor signaling pathway	P01355	AP1	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	IDA	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01440	Cadherin	MONDO|Ensembl=ENSMODG00000021410|UniProtKB=F7CBX9	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF91	CADHERIN-7
P02723	Adenine and hypoxanthine salvage pathway	P02809	Xanthine dehydrogenase	EMENI|EnsemblGenome=CADANIAG00003457|UniProtKB=Q12553	Xanthine dehydrogenase	ISS	7876088	PubMed	PTHR11908:SF100	XANTHINE DEHYDROGENASE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P02727	Androgen/estrogene/progesterone biosynthesis	P02829	Cholesterol acyltransferase	RAT|RGD=628865|UniProtKB=Q7TQM4	Sterol O-acyltransferase 2	NAS	21392392	gi	PTHR10408:SF10	STEROL O-ACYLTRANSFERASE 2
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ORYSJ|EnsemblGenome=OS03G0214600|UniProtKB=Q10Q05	Os03g0214600 protein	ISS			PTHR10539:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	MACMU|Ensembl=ENSMMUG00000004329|UniProtKB=F6ZDV3	Excitatory amino acid transporter 2 isoform 1	ISS	96032356	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	CAEEL|WormBase=WBGene00015540|UniProtKB=P50306	Probable S-adenosylmethionine synthase 4	ISS			PTHR11964:SF1	S-ADENOSYLMETHIONINE SYNTHASE
P05731	GABA-B receptor II signaling	P05752	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	RCA	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01284	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000011579|UniProtKB=F1N5C5	Muscarinic acetylcholine receptor	ISS			PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	HUMAN|HGNC=6696|UniProtKB=O75096	Low-density lipoprotein receptor-related protein 4	IDA	11907044	PubMed	PTHR44017:SF4	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4
P04398	p53 pathway feedback loops 2	P04657	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	8132661	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P05913	Enkephalin release	P05972	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	BOVIN|Ensembl=ENSBTAG00000026519|UniProtKB=Q5E9J7	tRNA-specific adenosine deaminase 2	ISS			PTHR11079:SF92	TRNA-SPECIFIC ADENOSINE DEAMINASE 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=24667|UniProtKB=Q8TD08	Mitogen-activated protein kinase 15	TAS	11875070	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P04393	Ras Pathway	P04560	AP1	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	12972619	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	SCHPO|PomBase=SPBC12D12.04c|UniProtKB=P36583	Protein kinase C-like 2	IC	93259141	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00053	T cell activation	P01322	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P02786	Vitamin B6 biosynthesis	P03225	1-Deoxyxylulose-5-phosphate synthase	PSEAE|EnsemblGenome=PA4044|UniProtKB=Q9KGU7	1-deoxy-D-xylulose-5-phosphate synthase	ISS			PTHR43322:SF6	1-DEOXY-D-XYLULOSE-5-PHOSPHATE SYNTHASE
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	RAT|RGD=628837|UniProtKB=P60711	Actin, cytoplasmic 1	IC	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00059	p53 pathway	G04694	p110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000000289|UniProtKB=F7A9T0	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CHICK|Ensembl=ENSGALG00000000839|UniProtKB=P49339	Protein Wnt-11	TAS	8717036	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00021	FGF signaling pathway	P00633	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	ISS	2372396	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00071	VAT1	MOUSE|MGI=MGI=106684|UniProtKB=Q8R090	Chromaffin granule amine transporter	ISS	92370677	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00047	PDGF signaling pathway	P01153	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	NEUCR|EnsemblGenome=EFNCRG00000000159|UniProtKB=F5HH30	Guanine nucleotide-binding protein beta subunit	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04393	Ras Pathway	P04556	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00790	beta-Tubulin	STRPU|EnsemblGenome=SPU_014285|UniProtKB=W4YEV4	Uncharacterized protein	ISS			PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CAEEL|WormBase=WBGene00006454|UniProtKB=G5EEN8	AEX-4	IC			PTHR19305:SF10	AEX-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00736	CalDAG-GEF	CANLF|Ensembl=ENSCAFG00000005870|UniProtKB=F1PL95	Uncharacterized protein	ISS	10835426	PubMed	PTHR23113:SF178	RAS GUANYL-RELEASING PROTEIN 3
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	CHICK|Ensembl=ENSGALG00000009405|UniProtKB=F1NKF1	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01435	SWI/SNF	RAT|RGD=1311869|UniProtKB=Q5U3Y2	Protein Smarcd3	ISS	11532957	PubMed	PTHR13844:SF5	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D MEMBER 3
P00034	Integrin signalling pathway	P00924	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02775	Salvage pyrimidine ribonucleotides	P03149	Cytidine kinase	ARATH|TAIR=AT1G55820|UniProtKB=A4FVR1	GBF-interacting protein 1-like	ISS			PTHR12758:SF30	GBF-INTERACTING PROTEIN 1-LIKE
P00059	p53 pathway	G04702	p53	BOVIN|Ensembl=ENSBTAG00000001069|UniProtKB=P67939	Cellular tumor antigen p53	TAS	14744434	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00005	Angiogenesis	P00217	STAT3	MOUSE|MGI=MGI=103038|UniProtKB=P42227	Signal transducer and activator of transcription 3	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00045	Notch signaling pathway	P01109	Aph-1	CAEEL|WormBase=WBGene00000147|UniProtKB=O45876	Gamma-secretase subunit aph-1	IPI	12110170	PubMed	PTHR12889:SF0	GAMMA-SECRETASE SUBUNIT APH-1
P04393	Ras Pathway	P04569	Cdc42	XENTR|Xenbase=XB-GENE-967585|UniProtKB=Q28BZ0	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00001	Adrenaline and noradrenaline biosynthesis	P00071	VAT1	RAT|RGD=3693|UniProtKB=Q01818	Chromaffin granule amine transporter	ISS	92370677	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00005	Angiogenesis	P00206	Wnt	XENTR|Xenbase=XB-GENE-480396|UniProtKB=F7DI28	Protein Wnt (Fragment)	ISS	11266476	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	IDA	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00059	p53 pathway	P04623	CBP	ARATH|TAIR=AT1G67220|UniProtKB=Q9FYH1	Histone acetyltransferase HAC2	IDA	8413673	PubMed	PTHR13808:SF6	HISTONE ACETYLTRANSFERASE HAC2
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=108061|UniProtKB=P48614	Protein Wnt-10b	IDA	12549854	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P06959	CCKR signaling map	P07141	LYN	HUMAN|HGNC=6735|UniProtKB=P07948	Tyrosine-protein kinase Lyn	RCA	16713446	PubMed	PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	RCA			PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MACMU|Ensembl=ENSMMUG00000020084|UniProtKB=F7GP56	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF427	MYOSIN-3
P04395	Vasopressin synthesis	P04599	Amidating Enzyme	HUMAN|HGNC=33751|UniProtKB=Q5JS37	NHL repeat-containing protein 3	IC			PTHR24104:SF8	NHL REPEAT-CONTAINING PROTEIN 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	MACMU|Ensembl=ENSMMUG00000014498|UniProtKB=F7GEI8	Uncharacterized protein	ISS	8386525	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	ISS	8557110	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00015	Circadian clock system	P00502	Casein kinase I	DANRE|ZFIN=ZDB-GENE-030131-825|UniProtKB=Q7T2E3	Casein kinase I isoform delta-A	ISS	10617630	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00050	Plasminogen activating cascade	P01264	alpha2 antiplasmin	BOVIN|Ensembl=ENSBTAG00000020859|UniProtKB=P28800	Alpha-2-antiplasmin	ISS	1168249	gi	PTHR11461:SF20	ALPHA-2-ANTIPLASMIN
P04398	p53 pathway feedback loops 2	G04711	SIAH-1	MACMU|Ensembl=ENSMMUG00000007400|UniProtKB=F6T3K3	E3 ubiquitin-protein ligase	ISS	14985507	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	SCLS1|EnsemblGenome=SS1G_04652|UniProtKB=A7EH60	Beta tubulin	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	PANTR|Ensembl=ENSPTRG00000016891|UniProtKB=H2R5K3	Uncharacterized protein	ISS	8940199	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00048	PI3 kinase pathway	P01192	p110	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00641	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=108071|UniProtKB=P70701	Protein Wnt-10a	TAS	11266476	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00030	Hypoxia response via HIF activation	P00819	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00053	T cell activation	P01300	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00029	Huntington disease	P00811	Arp2/3 complex	HUMAN|HGNC=708|UniProtKB=O15511	Actin-related protein 2/3 complex subunit 5	TAS	12473693	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00034	Integrin signalling pathway	P00947	Laminin	RAT|RGD=1307207|UniProtKB=D4A409	Laminin, alpha 1	ISS	2538453	PubMed	PTHR10574:SF299	LAMININ SUBUNIT ALPHA-1
P00010	B cell activation	P00371	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	RAT|RGD=620761|UniProtKB=Q9R172	Neurogenic locus notch homolog protein 3	IDA	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00990	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	IDA	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	94280860	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00005	Angiogenesis	P00243	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00786	ARF	DANRE|ZFIN=ZDB-GENE-030616-356|UniProtKB=Q78AP9	ADP-ribosylation factor 3b	ISS	12932731	PubMed	PTHR11711:SF234	ADP-RIBOSYLATION FACTOR 1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00053	T cell activation	P01336	Jnk	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00018	EGF receptor signaling pathway	P00551	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IGI	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00383	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00010	B cell activation	P00379	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00029	Huntington disease	P00805	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02728	Arginine biosynthesis	P02848	N-acetylglutamate synthase	PANTR|Ensembl=ENSPTRG00000009259|UniProtKB=H2QD56	N-acetylglutamate synthase	ISS			PTHR23342:SF0	N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL
P00059	p53 pathway	P01486	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	CAEBR|Gene=CBG07110|UniProtKB=A8X3N9	Protein CBR-ALH-6	ISS			PTHR42862:SF1	DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IC	22246731	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00029	Huntington disease	P00807	Actin	HUMAN|HGNC=145|UniProtKB=P63267	Actin, gamma-enteric smooth muscle	IDA	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00029	Huntington disease	P00811	Arp2/3 complex	PANTR|Ensembl=ENSPTRG00000021362|UniProtKB=H2QXW1	Actin-related protein 2/3 complex subunit 5	ISS	12932731	PubMed	PTHR12644:SF2	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5-LIKE PROTEIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00006	Apoptosis signaling pathway	P00302	ATF	ORNAN|Ensembl=ENSOANG00000008502|UniProtKB=F6XKJ2	Uncharacterized protein	ISS	11390664	PubMed	PTHR23351:SF23	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000008430|UniProtKB=F6VB97	Uncharacterized protein	ISS			PTHR11824:SF8	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MACMU|Ensembl=ENSMMUG00000017683|UniProtKB=F6UA63	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00047	PDGF signaling pathway	P01165	SRF	RAT|RGD=1559787|UniProtKB=D3ZHH8	Protein Srf	ISS	15647354	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00560	Raf-1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IDA	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00010	B cell activation	P00398	IP3R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	IC	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02788	Xanthine and guanine salvage pathway	P03245	Guanine phosphoribosyl transferase	RAT|RGD=2826|UniProtKB=P27605	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF6	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	CHICK|Ensembl=ENSGALG00000007509|UniProtKB=F1NM72	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00001	Adrenaline and noradrenaline biosynthesis	P00067	MAO	CANLF|Ensembl=ENSCAFG00000014435|UniProtKB=P58027	Amine oxidase [flavin-containing] A	ISS	8602220	PubMed	PTHR43563:SF3	AMINE OXIDASE  FLAVIN-CONTAINING  A
P00049	Parkinson disease	P01212	p38 MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	NAS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00030	Hypoxia response via HIF activation	P00819	AKT	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	IC	22084520	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DROME|FlyBase=FBgn0011745|UniProtKB=P45889	Actin-related protein 1	IC	14684598	PubMed	PTHR11937:SF195	BETA-CENTRACTIN
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P02787	Vitamin B6 metabolism	P03244	Pyridoxal kinase	SCHPO|PomBase=SPAC6F6.11c|UniProtKB=O14242	Putative pyridoxal kinase C6F6.11c	ISS	11859360	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P05915	Opioid proenkephalin pathway	P05990	K+ channel	CHICK|Ensembl=ENSGALG00000016193|UniProtKB=E1BYI0	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00034	Integrin signalling pathway	P00949	Shc	BOVIN|Ensembl=ENSBTAG00000019838|UniProtKB=Q0IIE2	SHC-transforming protein 1	ISS	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00047	PDGF signaling pathway	P01167	Ets	MACMU|Ensembl=ENSMMUG00000010296|UniProtKB=F6T339	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF216	TRANSCRIPTIONAL REGULATOR ERG
P06587	Nicotine pharmacodynamics pathway	P06598	EPB41L2	PANTR|Ensembl=ENSPTRG00000018597|UniProtKB=H2QTQ8	Erythrocyte membrane protein band 4.1-like 2	ISS	12181426	PubMed	PTHR23280:SF17	BAND 4.1-LIKE PROTEIN 2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00030	Hypoxia response via HIF activation	P00819	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	MOUSE|MGI=MGI=1351342|UniProtKB=Q3UVX5	Metabotropic glutamate receptor 5	ISS	7476890	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P04398	p53 pathway feedback loops 2	P04657	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00558	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	CHICK|Ensembl=ENSGALG00000003267|UniProtKB=Q6DV79	Signal transducer and activator of transcription 3	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	XENTR|Xenbase=XB-GENE-961282|UniProtKB=Q6DF43	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00012	Cadherin signaling pathway	P00475	Frizzled	ORNAN|Ensembl=ENSOANG00000004982|UniProtKB=F7DIA9	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF34	FRIZZLED-2
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	MOUSE|MGI=MGI=1349762|UniProtKB=Q62188	Dihydropyrimidinase-related protein 3	ISS	3122041	gi	PTHR11647:SF57	DIHYDROPYRIMIDINASE-RELATED PROTEIN 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	CHICK|Gene=RGS20|UniProtKB=Q9PWA1	Regulator of G-protein signaling 20	IDA	8756726	PubMed	PTHR10845:SF175	REGULATOR OF G-PROTEIN SIGNALING 20
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IDA	10644715	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	PSEAE|EnsemblGenome=PA4756|UniProtKB=P38100	Carbamoyl-phosphate synthase large chain	ISS			PTHR11405:SF5	CAD PROTEIN
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	ISS	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PLAF7|EnsemblGenome=PF11_0147|UniProtKB=Q7KQK7	Mitogen-activated protein kinase	IDA	10851062	PubMed	PTHR24055:SF189	SUBFAMILY NOT NAMED
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	NEMVE|Gene=v1g118944|UniProtKB=A7SHY4	Predicted protein (Fragment)	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00629	PP2A	DROME|FlyBase=FBgn0036212|UniProtKB=Q95TV5	Serine/threonine-protein phosphatase	ISS			PTHR11668:SF22	SERINE/THREONINE-PROTEIN PHOSPHATASE 4 CATALYTIC SUBUNIT
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	RCA			PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	XENTR|Xenbase=XB-GENE-967934|UniProtKB=Q6NVU2	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	ISS	8392016	PubMed	PTHR11668:SF204	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-GAMMA CATALYTIC SUBUNIT
P04376	5HT4 type receptor mediated signaling pathway	P04426	K+ channel	CHICK|Ensembl=ENSGALG00000016193|UniProtKB=E1BYI0	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	IDA	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00012	Cadherin signaling pathway	P00470	F-actin	RAT|RGD=2026|UniProtKB=P68035	Actin, alpha cardiac muscle 1	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00036	Interleukin signaling pathway	P00973	PKB	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01161	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00589	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IGI	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02741	Flavin biosynthesis	P02939	Lumazine synthase	ARATH|TAIR=AT2G44050|UniProtKB=O80575	6,7-dimethyl-8-ribityllumazine synthase, chloroplastic	ISS			PTHR21058:SF0	6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE
P00006	Apoptosis signaling pathway	P00260	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P04393	Ras Pathway	P04545	Sec5	MACMU|Ensembl=ENSMMUG00000023558|UniProtKB=F7HI15	Uncharacterized protein	ISS			PTHR13043:SF1	EXOCYST COMPLEX COMPONENT 2
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	CAEEL|WormBase=WBGene00000900|UniProtKB=P50488	Cell surface receptor daf-4	IDA	10887089	PubMed	PTHR23255:SF70	SERINE/THREONINE-PROTEIN KINASE RECEPTOR
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00010	B cell activation	P00375	Calmodulin	BOVIN|Ensembl=ENSBTAG00000001575|UniProtKB=F1N6C0	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF311	CALMODULIN
P00021	FGF signaling pathway	P00645	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=3765|UniProtKB=P30938	Somatostatin receptor type 5	IDA	12181435	PubMed	PTHR24229:SF20	SOMATOSTATIN RECEPTOR TYPE 5
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00021	FGF signaling pathway	P00628	JNK1-3	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02738	De novo purine biosynthesis	P02897	GTP reductase	METAC|EnsemblGenome=MA_0072|UniProtKB=Q8TUJ5	Anaerobic ribonucleoside-triphosphate reductase	ISS			PTHR21075:SF0	ANAEROBIC RIBONUCLEOSIDE-TRIPHOSPHATE REDUCTASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	BOVIN|Ensembl=ENSBTAG00000019095|UniProtKB=D9ZDE4	Chemokine (C-C motif) receptor 10	ISS	11821900	PubMed	PTHR10489:SF773	C-C CHEMOKINE RECEPTOR TYPE 10
P00005	Angiogenesis	P00223	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00590	IP3 R	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	IGI	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	TAS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04566	Stat 1/3	MONDO|Ensembl=ENSMODG00000028212|UniProtKB=F7BYN4	Signal transducer and activator of transcription	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P02729	Ascorbate degradation	P02849	L-xylulose kinase	BACTN|EnsemblGenome=BT_0792|UniProtKB=Q8A9M3	Xylulose kinase (Xylulokinase)	ISS			PTHR43095:SF5	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00589	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IGI	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IPI	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01076	CAT	CHICK|Gene=CHAT|UniProtKB=Q90YJ9	Choline O-acetyltransferase	ISS	92155737	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IDA	8787761	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	12707323	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00054	Toll receptor signaling pathway	P01352	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00053	T cell activation	P01300	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DANRE|ZFIN=ZDB-GENE-000330-4|UniProtKB=Q1MTI1	Uncharacterized protein	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8667|UniProtKB=Q9Y5I0	Protocadherin alpha-13	IDA	8120095	PubMed	PTHR24028:SF101	PROTOCADHERIN ALPHA-13
P00036	Interleukin signaling pathway	P00990	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02775	Salvage pyrimidine ribonucleotides	P03150	Uridine kinase	PANTR|Ensembl=ENSPTRG00000001619|UniProtKB=H2Q0I7	Uridine-cytidine kinase	ISS			PTHR10285:SF70	URIDINE-CYTIDINE KINASE 2
P00029	Huntington disease	P00796	Kainate receptor	DANRE|Ensembl=ENSDARG00000070511|UniProtKB=E7F5R2	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF282	GLUTAMATE RECEPTOR-RELATED
P00021	FGF signaling pathway	P00631	Grb2	DANRE|ZFIN=ZDB-GENE-040426-1975|UniProtKB=Q6PC73	Growth factor receptor-bound protein 2	ISS	http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd	Website	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00019	Endothelin signaling pathway	P00586	Gq	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P02723	Adenine and hypoxanthine salvage pathway	P02808	Deoxyadenosine phosphorylase	CAEBR|Gene=CBG13501|UniProtKB=A8XI15	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00029	Huntington disease	P00799	JNK-2	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	RAT|RGD=2522|UniProtKB=P30729	D(4) dopamine receptor	ISS	2137198	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	HUMAN|HGNC=10431|UniProtKB=Q15349	Ribosomal protein S6 kinase alpha-2	ISS	15526037	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00059	p53 pathway	P04633	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00470	F-actin	SCHMA|EnsemblGenome=Smp_202970|UniProtKB=G4VLN1	Putative uncharacterized protein Smp_202970	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00925	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	IDA	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00018	EGF receptor signaling pathway	P00545	JNK1-3	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	CAEBR|Gene=CBG01097|UniProtKB=A8WPJ8	Protein CBR-CMD-1	ISS	9753452	PubMed	PTHR23050:SF236	CALMODULIN
P04393	Ras Pathway	P04570	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IC	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	DROME|FlyBase=FBgn0001991|UniProtKB=Q24270	Voltage-dependent calcium channel type D subunit alpha-1	ISS	10514528	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00021	FGF signaling pathway	P00629	PP2A	ARATH|TAIR=AT1G13320|UniProtKB=Q38951	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A gamma isoform	ISS			PTHR10648:SF4	PROTEIN PHOSPHATASE 2  FORMERLY 2A , REGULATORY SUBUNIT A, BETA ISOFORM
P00018	EGF receptor signaling pathway	P00564	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CANLF|Ensembl=ENSCAFG00000019169|UniProtKB=F1Q147	Uncharacterized protein	ISS			PTHR13140:SF255	UNCONVENTIONAL MYOSIN-IC
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ANOGA|EnsemblGenome=AGAP001506|UniProtKB=Q7PXP3	AGAP001506-PA	IC	10391901	PubMed	PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P02747	Histidine biosynthesis	P02991	Histidinephosphate aminotransferase	STRCO|EnsemblGenome=CAB51445|UniProtKB=P16246	Histidinol-phosphate aminotransferase	ISS			PTHR42885:SF2	HISTIDINOL-PHOSPHATE AMINOTRANSFERASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00839	SHIP	BOVIN|Ensembl=ENSBTAG00000019167|UniProtKB=E1BBJ7	Uncharacterized protein	ISS	10610720	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00047	PDGF signaling pathway	P01154	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00053	T cell activation	P01336	Jnk	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04397	p53 pathway by glucose deprivation	P04636	S6K	RAT|RGD=620683|UniProtKB=P67999	Ribosomal protein S6 kinase beta-1	IDA	11861821	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	IDA	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	HUMAN|HGNC=4597|UniProtKB=P41594	Metabotropic glutamate receptor 5	ISS	9407094	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	HUMAN|HGNC=4583|UniProtKB=Q16478	Glutamate receptor ionotropic, kainate 5	ISS	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00018	EGF receptor signaling pathway	P00546	GAP	HUMAN|HGNC=7765|UniProtKB=P21359	Neurofibromin	ISS	95047432	PubMed	PTHR10194:SF60	NEUROFIBROMIN
P00011	Blood coagulation	P00406	Fibrinogen	HUMAN|HGNC=3694|UniProtKB=P02679	Fibrinogen gamma chain	ISS	80015086	PubMed	PTHR19143:SF338	FIBRINOGEN GAMMA CHAIN
P02780	Thiamin metabolism	P03184	Thiamine triphosphatase	PANTR|Ensembl=ENSPTRG00000006180|UniProtKB=H2Q810	Thiamine-triphosphatase	ISS	11827967	PubMed	PTHR14586:SF1	THIAMINE-TRIPHOSPHATASE
P00059	p53 pathway	P04633	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02913	Thymidylate synthase	PSEAE|EnsemblGenome=PA0342|UniProtKB=Q9I6F1	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00006	Apoptosis signaling pathway	P00278	Bag	RAT|RGD=1307794|UniProtKB=Q5U2U8	Bcl2-associated athanogene 3	ISS			PTHR12329:SF12	BAG FAMILY MOLECULAR CHAPERONE REGULATOR 3
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00645	Rac	DROME|FlyBase=FBgn0010333|UniProtKB=P40792	Ras-related protein Rac1	IGI	8649368	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00029	Huntington disease	P00780	Microtubule	MONDO|Ensembl=ENSMODG00000016603|UniProtKB=F6ZCX3	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF112	TUBULIN BETA-1 CHAIN
P00059	p53 pathway	G04702	p53	RAT|RGD=620863|UniProtKB=Q9JJP6	Tumor protein 63	TAS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IDA	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00030	Hypoxia response via HIF activation	P00819	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00383	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IDA	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	IDA	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	RAT|RGD=620314|UniProtKB=B0LPN4	Ryanodine receptor 2	ISS	8930069	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MACMU|Ensembl=ENSMMUG00000008421|UniProtKB=F6VCH4	Smad nuclear-interacting protein 1	ISS	10400677	PubMed	PTHR23308:SF36	SMAD NUCLEAR-INTERACTING PROTEIN 1
P00057	Wnt signaling pathway	P01443	Phospholipase C	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MACMU|Ensembl=ENSMMUG00000009600|UniProtKB=F7AC65	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF291	ADENYLATE CYCLASE TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00021	FGF signaling pathway	P00648	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	DROME|FlyBase=FBgn0019947|UniProtKB=O02194	Presenilin homolog	TAS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00019	Endothelin signaling pathway	P00570	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	XENTR|Xenbase=XB-GENE-494200|UniProtKB=F7CS79	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00049	Parkinson disease	P01211	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CANLF|Ensembl=ENSCAFG00000005662|UniProtKB=E2R907	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00007	Axon guidance mediated by semaphorins	P00341	Rho	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	ISS	10556059	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P05915	Opioid proenkephalin pathway	P05989	leu-Enkephalin	XENTR|Xenbase=XB-GENE-942760|UniProtKB=F6Y5F6	Uncharacterized protein	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00046	Oxidative stress response	P01138	MKK4	MOUSE|MGI=MGI=1346869|UniProtKB=P47809	Dual specificity mitogen-activated protein kinase kinase 4	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00024	Glycolysis	P00677	Hexokinase	DROME|FlyBase=FBgn0001186|UniProtKB=Q9W330	Phosphotransferase	RCA			PTHR19443:SF53	HEXOKINASE TYPE 1-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01448	CBP	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00006	Apoptosis signaling pathway	P00307	ELF2alpha	MOUSE|MGI=MGI=95299|UniProtKB=Q6ZWX6	Eukaryotic translation initiation factor 2 subunit 1	ISS	10889505	PubMed	PTHR10602:SF0	EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1
P00060	Ubiquitin proteasome pathway	P01491	E2	BRAFL|Gene=BRAFLDRAFT_285353|UniProtKB=C3ZGJ2	Putative uncharacterized protein	ISS			PTHR24068:SF120	UBIQUITIN-CONJUGATING ENZYME E2D 2  UBC4/5 HOMOLOG, YEAST
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	NAS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00023	General transcription regulation	P00658	TBP-associated factors	BOVIN|Ensembl=ENSBTAG00000026306|UniProtKB=G3MXQ4	Uncharacterized protein	ISS			PTHR12264:SF21	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02738	De novo purine biosynthesis	P02894	IMP cyclohydrolase	HALSA|EnsemblGenome=VNG_0414G|UniProtKB=Q9HS43	Phosphoribosylaminoimidazole-succinocarboxamide formyltransferase	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00006	Apoptosis signaling pathway	P00269	MAPK	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00004	Alzheimer disease-presenilin pathway	P00168	E-cadherin intracellular fragment	PANTR|Ensembl=ENSPTRG00000008269|UniProtKB=H2QBE4	Cadherin 3, type 1, P-cadherin (Placental)	ISS	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	MOUSE|MGI=MGI=1930182|UniProtKB=Q9WV85	Nucleoside diphosphate kinase 3	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	DANRE|ZFIN=ZDB-GENE-040718-93|UniProtKB=Q6DGZ5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00005	Angiogenesis	P00223	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	BRAFL|Gene=BRAFLDRAFT_60743|UniProtKB=C3XYD4	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P05916	Opioid prodynorphin pathway	P06002	G-protein	TAKRU|Ensembl=ENSTRUG00000016101|UniProtKB=H2UW32	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00756	Recoverin	MACMU|Ensembl=ENSMMUG00000018091|UniProtKB=F7EG53	Cancer-associated retinopathy protein	ISS	9753452	PubMed	PTHR23055:SF20	RECOVERIN
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02765	Phenylalanine biosynthesis	P03100	Chorismate mutase	ARATH|TAIR=AT3G29200|UniProtKB=P42738	Chorismate mutase 1, chloroplastic	ISS			PTHR21145:SF0	CHORISMATE MUTASE
P00009	Axon guidance mediated by netrin	P00366	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00047	PDGF signaling pathway	P01154	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	RAT|RGD=619966|UniProtKB=F1LQT1	Adenylate cyclase 7	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00005	Angiogenesis	P00243	Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00046	Oxidative stress response	P01135	p38	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	8925912	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04393	Ras Pathway	P04572	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IDA	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT4G01370|UniProtKB=Q39024	Mitogen-activated protein kinase 4	ISS	2191146	gi	PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P05915	Opioid proenkephalin pathway	P05993	AC	BOVIN|Ensembl=ENSBTAG00000019210|UniProtKB=F1MJV4	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00018	EGF receptor signaling pathway	P00562	p38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00060	Ubiquitin proteasome pathway	P01492	E1	MACMU|Ensembl=ENSMMUG00000005884|UniProtKB=F6TLE0	Uncharacterized protein	ISS			PTHR10953:SF5	SUMO-ACTIVATING ENZYME SUBUNIT 2
P00029	Huntington disease	P00798	Clathrin	MOUSE|MGI=MGI=1921575|UniProtKB=Q6IRU5	Clathrin light chain B	ISS	9388255	PubMed	PTHR10639:SF2	CLATHRIN LIGHT CHAIN B
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05731	GABA-B receptor II signaling	P05754	Ggamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00010	B cell activation	P00385	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00054	Toll receptor signaling pathway	P01368	MKK2	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00006	Apoptosis signaling pathway	P00322	Cytochrome C	BOVIN|Ensembl=ENSBTAG00000039522|UniProtKB=Q3SZT9	Cytochrome c 2	ISS			PTHR11961:SF6	CYTOCHROME C, TESTIS-SPECIFIC
P00047	PDGF signaling pathway	P01167	Ets	CANLF|Ensembl=ENSCAFG00000003733|UniProtKB=E2QU99	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF10	ETS-RELATED TRANSCRIPTION FACTOR ELF-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00561	STAT	BOVIN|Gene=STAT3|UniProtKB=P61635	Signal transducer and activator of transcription 3	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	CHICK|Gene_ORFName=RCJMB04_3m24|UniProtKB=Q5F418	26S proteasome non-ATPase regulatory subunit 1	ISS			PTHR10943:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=621254|UniProtKB=A0A0G2K5L1	Protein Fat1	IDA	8120095	PubMed	PTHR24026:SF42	PROTOCADHERIN FAT 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06760	MKK4/7	MOUSE|MGI=MGI=1346869|UniProtKB=P47809	Dual specificity mitogen-activated protein kinase kinase 4	RCA	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	HUMAN|HGNC=708|UniProtKB=O15511	Actin-related protein 2/3 complex subunit 5	ISS	12932731	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	RAT|RGD=1305018|UniProtKB=D3ZF63	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8711|UniProtKB=Q9UN71	Protocadherin gamma-B4	IDA	8120095	PubMed	PTHR24028:SF117	PROTOCADHERIN GAMMA-B4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P06959	CCKR signaling map	P07149	cGK 1	HUMAN|HGNC=9414|UniProtKB=Q13976	cGMP-dependent protein kinase 1	RCA	7721818	PubMed	PTHR24353:SF68	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=13829|UniProtKB=Q9GZT5	Protein Wnt-10a	IDA	8717036	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00047	PDGF signaling pathway	P01164	PDK1/2	DROME|FlyBase=FBgn0020386|UniProtKB=Q9W0V1	3-phosphoinositide-dependent protein kinase 1	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00254	GTPase	HUMAN|HGNC=667|UniProtKB=P61586	Transforming protein RhoA	ISS	12169092	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	PANTR|Ensembl=ENSPTRG00000016158|UniProtKB=H2QPN6	C-X-C motif chemokine	ISS	9910486	gi	PTHR10179:SF43	PLATELET FACTOR 4
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	MOUSE|MGI=MGI=1202403|UniProtKB=G3X8Z7	MCG5735	IC			PTHR18945:SF489	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-9
P04393	Ras Pathway	P04544	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8479536	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00623	FGF	CHICK|Ensembl=ENSGALG00000006508|UniProtKB=F1NWP9	Fibroblast growth factor	IGI	9847253	PubMed	PTHR11486:SF77	FIBROBLAST GROWTH FACTOR 13
P04393	Ras Pathway	P04542	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01335	jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	3136397	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00005	Angiogenesis	P00194	Paxillin	HUMAN|HGNC=14061|UniProtKB=O60711	Leupaxin	ISS			PTHR24216:SF23	LEUPAXIN
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00030	Hypoxia response via HIF activation	P00814	P300	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	IDA	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00036	Interleukin signaling pathway	P00990	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01150	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00054	Toll receptor signaling pathway	P01379	Tollip	MOUSE|MGI=MGI=1891808|UniProtKB=Q9QZ06	Toll-interacting protein	ISS			PTHR16461:SF5	TOLL-INTERACTING PROTEIN
P00023	General transcription regulation	P00668	TFIIB	DAPPU|EnsemblGenome=DAPPUDRAFT_304965|UniProtKB=E9GMZ1	Putative uncharacterized protein	ISS			PTHR12458:SF8	CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20
P00034	Integrin signalling pathway	P00944	Actin	BOVIN|Ensembl=ENSBTAG00000006189|UniProtKB=P63258	Actin, cytoplasmic 2	ISS	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00035	Interferon-gamma signaling pathway	P00960	PTP	DANRE|ZFIN=ZDB-GENE-030131-5911|UniProtKB=F1QZU5	Tyrosine-protein phosphatase non-receptor type	ISS	7681589	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01194	S6K	ORNAN|Ensembl=ENSOANG00000002226|UniProtKB=F6TPX7	Ribosomal protein S6 kinase	ISS	11861821	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P04392	P53 pathway feedback loops 1	P04537	p73DeltaN	ORNAN|Ensembl=ENSOANG00000013795|UniProtKB=F7DUR2	Uncharacterized protein (Fragment)	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00012	Cadherin signaling pathway	P00475	Frizzled	ANOGA|Gene=AgaP_AGAP011382|UniProtKB=Q7Q2X0	AGAP011382-PA (Fragment)	ISS	8717036	PubMed	PTHR11309:SF47	FRIZZLED
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	YEAST|SGD=S000005854|UniProtKB=P33328	Synaptobrevin homolog 2	IC			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00036	Interleukin signaling pathway	P00965	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P06664	Gonadotropin-releasing hormone receptor pathway	P06721	PPARgamma	MOUSE|MGI=MGI=97747|UniProtKB=P37238	Peroxisome proliferator-activated receptor gamma	RCA			PTHR24082:SF14	PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00030	Hypoxia response via HIF activation	P00817	TOR	YEAST|SGD=S000001686|UniProtKB=P32600	Serine/threonine-protein kinase TOR2	TAS	14526383	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00029	Huntington disease	P00796	Kainate receptor	CHICK|Ensembl=ENSGALG00000001172|UniProtKB=P19439	Probable glutamate receptor	IDA	12778120	PubMed	PTHR18966:SF282	GLUTAMATE RECEPTOR-RELATED
P00005	Angiogenesis	P00227	PLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	IDA	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00012	Cadherin signaling pathway	P00474	Wnt	CAEEL|WormBase=WBGene00001188|UniProtKB=G5EG05	Uncharacterized protein	IDA	8717036	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P00010	B cell activation	P00369	MEKK	MACMU|Ensembl=ENSMMUG00000018568|UniProtKB=F6YLW2	Uncharacterized protein	ISS	21735556	gi	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	TAS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06831	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	RCA	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00021	FGF signaling pathway	P00643	Raf-1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05977	G-Protein (s)	CAEEL|WormBase=WBGene00001679|UniProtKB=P17343	Guanine nucleotide-binding protein subunit beta-1	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P02727	Androgen/estrogene/progesterone biosynthesis	P02829	Cholesterol acyltransferase	HUMAN|HGNC=11177|UniProtKB=P35610	Sterol O-acyltransferase 1	ISS	7592824	PubMed	PTHR10408:SF6	STEROL O-ACYLTRANSFERASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00024	Glycolysis	P00671	Phosphoglycerate kinase	CANLF|Ensembl=ENSCAFG00000017270|UniProtKB=E2RRC9	Phosphoglycerate kinase	ISS	79199779	PubMed	PTHR11406:SF14	PHOSPHOGLYCERATE KINASE 1
P00053	T cell activation	P01312	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	TAKRU|Ensembl=ENSTRUG00000004787|UniProtKB=P53480	Actin, alpha cardiac	ISS	10974003	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00036	Interleukin signaling pathway	P00990	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00226	Delta/Serrate	MONDO|Ensembl=ENSMODG00000004910|UniProtKB=F7C1Q4	Delta-like protein	ISS	8631496	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00036	Interleukin signaling pathway	P00981	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00048	PI3 kinase pathway	P01205	NOS	BOVIN|Gene=NOS3|UniProtKB=P29473	Nitric oxide synthase, endothelial	ISS	9837777	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00029	Huntington disease	P00786	ARF	PANTR|Ensembl=ENSPTRG00000006324|UniProtKB=H2Q894	ADP-ribosylation factor 6	ISS	12932731	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P04398	p53 pathway feedback loops 2	P04654	Rb	BOVIN|Ensembl=ENSBTAG00000006640|UniProtKB=F1MD46	Uncharacterized protein	ISS			PTHR13742:SF17	RETINOBLASTOMA-ASSOCIATED PROTEIN
P00053	T cell activation	P01307	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00310	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00970	Interleukin	RAT|RGD=2890|UniProtKB=P16598	Interleukin-1 alpha	IC			PTHR45409:SF1	INTERLEUKIN-1 ALPHA
P00021	FGF signaling pathway	P00623	FGF	MOUSE|MGI=MGI=1099809|UniProtKB=O35565	Fibroblast growth factor 10	ISS	20411101	PubMed	PTHR11486:SF21	FIBROBLAST GROWTH FACTOR 10
P00034	Integrin signalling pathway	P00925	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00786	ARF	RAT|RGD=621270|UniProtKB=P84079	ADP-ribosylation factor 1	ISS	12932731	PubMed	PTHR11711:SF234	ADP-RIBOSYLATION FACTOR 1
P00010	B cell activation	P00401	jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_60743|UniProtKB=C3XYD4	Putative uncharacterized protein	ISS			PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	MACMU|Ensembl=ENSMMUG00000003718|UniProtKB=F6S807	Uncharacterized protein	ISS	9783586	PubMed	PTHR10814:SF23	TRANSDUCIN-LIKE ENHANCER PROTEIN 1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MACMU|Ensembl=ENSMMUG00000007263|UniProtKB=F7FGG2	Preproendothelin-1	ISS	12907686	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P00046	Oxidative stress response	P01129	JNK1/2	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	CHICK|Ensembl=ENSGALG00000017238|UniProtKB=F1NWG3	Uncharacterized protein	ISS	8314195	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01304	Csk	MOUSE|MGI=MGI=88537|UniProtKB=P41241	Tyrosine-protein kinase CSK	IDA	7687537	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P06959	CCKR signaling map	P07163	SRC @Galphaq	HUMAN|HGNC=11283|UniProtKB=P12931	Proto-oncogene tyrosine-protein kinase Src	RCA	9230117	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P02785	Valine biosynthesis	P03215	Branched chain amino acid aminotransferase	DEIRA|EnsemblGenome=DR_1626|UniProtKB=Q9RTX5	Branched-chain-amino-acid aminotransferase	ISS			PTHR42825:SF2	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 3, CHLOROPLASTIC
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=283|UniProtKB=P18825	Alpha-2C adrenergic receptor	IDA	11781138	PubMed	PTHR24248:SF25	ALPHA-2C ADRENERGIC RECEPTOR
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000012922|UniProtKB=H2QJF2	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MOUSE|MGI=MGI=107191|UniProtKB=P36898	Bone morphogenetic protein receptor type-1B	TAS	10683140	PubMed	PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	MACMU|Gene=CCL18|UniProtKB=Q8HYP8	C-C motif chemokine 18	ISS	12401480	PubMed	PTHR12015:SF94	C-C MOTIF CHEMOKINE 18
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	TAKRU|Ensembl=ENSTRUG00000016472|UniProtKB=H2UYR6	Uncharacterized protein	ISS			PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00018	EGF receptor signaling pathway	P00556	PLCgamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P06587	Nicotine pharmacodynamics pathway	P06598	EPB41L2	HUMAN|HGNC=3379|UniProtKB=O43491	Band 4.1-like protein 2	IDA	12181426	PubMed	PTHR23280:SF17	BAND 4.1-LIKE PROTEIN 2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00019	Endothelin signaling pathway	P00590	IP3 R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00053	T cell activation	P01307	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05731	GABA-B receptor II signaling	P05754	Ggamma	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00034	Integrin signalling pathway	P00912	Arp2/3	PANTR|Ensembl=ENSPTRG00000019449|UniProtKB=H2QV01	Actin related protein 2/3 complex, subunit 1B, 41kDa	ISS	12963527	gi	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06790	DGK-zeta	MOUSE|MGI=MGI=1278339|UniProtKB=Q80UP3	Diacylglycerol kinase zeta	RCA			PTHR11255:SF43	DIACYLGLYCEROL KINASE ZETA
P00047	PDGF signaling pathway	P01167	Ets	MOUSE|MGI=MGI=95455|UniProtKB=P27577	Protein C-ets-1	ISS	15579511	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P02726	Aminobutyrate degradation	P02825	4-aminobutyrate aminotransferase	ANOGA|EnsemblGenome=AGAP006966|UniProtKB=Q7QIN5	AGAP006966-PA	ISS	8133261	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	RAT|RGD=620436|UniProtKB=P11962	Glycoprotein hormones alpha chain	ISS	89325834	PubMed	PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CANLF|Ensembl=ENSCAFG00000016020|UniProtKB=O18840	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00029	Huntington disease	P00785	Cytochrome c	HUMAN|HGNC=2579|UniProtKB=P08574	Cytochrome c1, heme protein, mitochondrial	ISS	9027315	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00020	FAS signaling pathway	P00611	Gelsolin	MOUSE|MGI=MGI=1098259|UniProtKB=P24452	Macrophage-capping protein	IGI	9323209	PubMed	PTHR11977:SF13	MACROPHAGE-CAPPING PROTEIN
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	BACSU|EnsemblGenome=BSU22730|UniProtKB=P31103	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P04392	P53 pathway feedback loops 1	P04539	p53	CANLF|Gene=TP53|UniProtKB=Q29537	Cellular tumor antigen p53	TAS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347742|UniProtKB=E9FZ00	Cytoplasmatic actin	ISS	14684598	PubMed	PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P04393	Ras Pathway	P04556	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	IDA	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PANTR|Ensembl=ENSPTRG00000009762|UniProtKB=H2QE24	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04380	Cortocotropin releasing factor receptor signaling pathway	P04451	CRHR1	CHICK|Gene=CRHR1|UniProtKB=Q90812	Corticotropin-releasing factor receptor 1	ISS	11145609	PubMed	PTHR12011:SF175	CORTICOTROPIN-RELEASING FACTOR RECEPTOR 1
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	MOUSE|MGI=MGI=95809|UniProtKB=P23819	Glutamate receptor 2	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT1G59580|UniProtKB=Q39022	Mitogen-activated protein kinase 2	ISS	15218451	gi	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00048	PI3 kinase pathway	P01179	PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00474	Wnt	DANRE|ZFIN=ZDB-GENE-980526-526|UniProtKB=P24257	Protein Wnt-1	IDA	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00048	PI3 kinase pathway	P01192	p110	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01465	Ggamma	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DANRE|ZFIN=ZDB-GENE-000330-4|UniProtKB=Q1MTI1	Uncharacterized protein	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00034	Integrin signalling pathway	P00907	ERK	BOVIN|Ensembl=ENSBTAG00000008151|UniProtKB=F1MH06	Uncharacterized protein	ISS			PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00053	T cell activation	P01319	PAK	XENTR|Xenbase=XB-GENE-966302|UniProtKB=F6T2E7	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P02726	Aminobutyrate degradation	P02825	4-aminobutyrate aminotransferase	STRCO|Gene=CAA20213|UniProtKB=O86823	Putative 4-aminobutyrate aminotransferase	ISS			PTHR43206:SF2	4-AMINOBUTYRATE AMINOTRANSFERASE GABT
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00046	Oxidative stress response	P01124	Myc	PANTR|Gene=MYC|UniProtKB=P23583	Myc proto-oncogene protein	TAS	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00049	Parkinson disease	P01211	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02787	Vitamin B6 metabolism	P03244	Pyridoxal kinase	DICDI|dictyBase=DDB_G0268628|UniProtKB=Q55EK9	Pyridoxal kinase	IDA	10930737	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P00034	Integrin signalling pathway	P00912	Arp2/3	BOVIN|Ensembl=ENSBTAG00000046248|UniProtKB=Q58CQ2	Actin-related protein 2/3 complex subunit 1B	IPI	12932731	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00048	PI3 kinase pathway	P01182	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	9395335	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02916	dTMP kinase	HALSA|EnsemblGenome=VNG_1929G|UniProtKB=Q9HNV4	Probable thymidylate kinase	ISS			PTHR10344:SF1	THYMIDYLATE KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	ISS	10704417	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00019	Endothelin signaling pathway	P00590	IP3 R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	BOVIN|Ensembl=ENSBTAG00000014828|UniProtKB=F1N1E0	Uncharacterized protein	ISS	8386525	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00021	FGF signaling pathway	P00624	14-3-3	SCHPO|PomBase=SPAC8E11.02c|UniProtKB=P42656	DNA damage checkpoint protein rad24	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00035	Interferon-gamma signaling pathway	P00960	PTP	TAKRU|Ensembl=ENSTRUG00000018529|UniProtKB=H2VDZ2	Tyrosine-protein phosphatase non-receptor type	ISS	14534538	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00012	Cadherin signaling pathway	P00470	F-actin	STRPU|Gene=CYIIIA|UniProtKB=P53474	Actin, cytoskeletal 3A	IC	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00018	EGF receptor signaling pathway	P00558	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04377	Beta1 adrenergic receptor signaling pathway	P04433	Beta1	MOUSE|MGI=MGI=87937|UniProtKB=P34971	Beta-1 adrenergic receptor	ISS	12063255	PubMed	PTHR24248:SF54	BETA-1 ADRENERGIC RECEPTOR
P00029	Huntington disease	P00787	MAPKK4	BOVIN|Ensembl=ENSBTAG00000012103|UniProtKB=A5PJP8	MAP2K4 protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	ORYSJ|EnsemblGenome=OS06G0671900|UniProtKB=Q40665	Tubulin beta-3 chain	ISS	9454836	PubMed	PTHR11588:SF245	TUBULIN BETA-4 CHAIN-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00011	Blood coagulation	P00429	PN2	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	ISS	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=98960|UniProtKB=P22727	Protein Wnt-6	IDA	8717036	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00011	Blood coagulation	P00408	Plasminogen	MOUSE|MGI=MGI=97620|UniProtKB=P20918	Plasminogen	ISS	15928602	gi	PTHR24261:SF5	PLASMINOGEN
P00034	Integrin signalling pathway	P00923	Arf1	TAKRU|Ensembl=ENSTRUG00000014335|UniProtKB=H2UI79	Uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF294	ADP-RIBOSYLATION FACTOR 3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00018	EGF receptor signaling pathway	P00556	PLCgamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00624	14-3-3	CANLF|Ensembl=ENSCAFG00000014869|UniProtKB=E2REA4	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	BOVIN|Ensembl=ENSBTAG00000010111|UniProtKB=F1MJS2	Uncharacterized protein	ISS	12356903	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	ASHGO|EnsemblGenome=AGOS_AGL093W|UniProtKB=Q9HF56	Cell division control protein 42	ISS	12932731	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00059	p53 pathway	P04619	HMG1	CANLF|Ensembl=ENSCAFG00000006597|UniProtKB=Q6YKA4	High mobility group protein B1	ISS			PTHR13711:SF164	HIGH MOBILITY GROUP PROTEIN B1-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00047	PDGF signaling pathway	P01148	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00021	FGF signaling pathway	P00624	14-3-3	CHICK|Ensembl=ENSGALG00000004143|UniProtKB=Q5ZLQ6	14-3-3 protein beta/alpha	ISS	91108808	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00005	Angiogenesis	P00240	FRS-2	PANTR|Ensembl=ENSPTRG00000018159|UniProtKB=H2QSZ7	Uncharacterized protein	ISS			PTHR21258:SF39	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 3
P02722	Acetate utilization	P02801	Acetate kinase	THEMA|EnsemblGenome=TM_0274|UniProtKB=Q9WYB1	Acetate kinase	ISS			PTHR21060:SF11	SUBFAMILY NOT NAMED
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346873|UniProtKB=Q61083	Mitogen-activated protein kinase kinase kinase 2	ISS			PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00045	Notch signaling pathway	P01099	Notch	BOVIN|Ensembl=ENSBTAG00000007909|UniProtKB=F1MPE9	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	TAKRU|Ensembl=ENSTRUG00000000172|UniProtKB=H2RJP1	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF103	PROTEIN WNT-4A
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	SCLS1|EnsemblGenome=SS1G_13801|UniProtKB=A7F871	Uncharacterized protein	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00034	Integrin signalling pathway	P00936	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06959	CCKR signaling map	P07110	PLC_beta	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	RCA	1309799	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00037	Ionotropic glutamate receptor pathway	P01015	Glu4	CHICK|Ensembl=ENSGALG00000017178|UniProtKB=F1N982	Uncharacterized protein	ISS	12497607	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	TAS	12736250	PubMed	PTHR10202:SF18	PRESENILIN-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01412	HSP27	HUMAN|HGNC=5246|UniProtKB=P04792	Heat shock protein beta-1	IDA			PTHR11527:SF114	HEAT SHOCK PROTEIN BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	BOVIN|Ensembl=ENSBTAG00000006675|UniProtKB=F1MCT1	Uncharacterized protein	ISS			PTHR42884:SF8	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 6
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2845|UniProtKB=P19327	5-hydroxytryptamine receptor 1A	IDA	12181435	PubMed	PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ORYSJ|EnsemblGenome=OS03G0285800|UniProtKB=Q10N20	Mitogen-activated protein kinase 5	ISS	9836510	gi	PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02778	Sulfate assimilation	P03165	Sulfite reductase	YEAST|SGD=S000001926|UniProtKB=P39692	Sulfite reductase [NADPH] flavoprotein component	RCA			PTHR19384:SF89	SULFITE REDUCTASE  NADPH  FLAVOPROTEIN COMPONENT
P00014	Cholesterol biosynthesis	P00499	Farnesyl-diphosphate farnesyltransferase	CANAL|CGD=CAL0000316|UniProtKB=Q59Y33	Squalene synthase	ISS			PTHR11626:SF2	SQUALENE SYNTHASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00034	Integrin signalling pathway	P00917	ELMO	PANTR|Ensembl=ENSPTRG00000013583|UniProtKB=H2QKI4	Engulfment and cell motility 2	ISS	12879077	PubMed	PTHR12771:SF8	ENGULFMENT AND CELL MOTILITY PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MACMU|Ensembl=ENSMMUG00000009316|UniProtKB=F7HLU2	Uncharacterized protein	ISS	6680790	gi	PTHR10489:SF618	C-X-C CHEMOKINE RECEPTOR TYPE 5
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	PANTR|Ensembl=ENSPTRG00000000843|UniProtKB=H2QZN8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00018	EGF receptor signaling pathway	P00561	STAT	CANLF|Ensembl=ENSCAFG00000015213|UniProtKB=E2RB82	Signal transducer and activator of transcription	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00045	Notch signaling pathway	P01120	NIcs	MACMU|Ensembl=ENSMMUG00000017022|UniProtKB=F7HQZ9	Uncharacterized protein	ISS	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00017	DNA replication	P00527	Histones	CAEBR|Gene=CBG01499|UniProtKB=G2J6C6	Histone H3	ISS	12413958	PubMed	PTHR11426:SF167	HISTONE H3.1
P00045	Notch signaling pathway	P01115	Neurotic	PANTR|Ensembl=ENSPTRG00000006454|UniProtKB=Q6EV77	Alpha-(1,6)-fucosyltransferase	ISS			PTHR13132:SF29	ALPHA- 1,6 -FUCOSYLTRANSFERASE
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00029	Huntington disease	P00790	beta-Tubulin	RAT|RGD=735101|UniProtKB=Q6P9T8	Tubulin beta-4B chain	ISS	9454836	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IC	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS	88311074	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	RCA	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05731	GABA-B receptor II signaling	P05752	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00018	EGF receptor signaling pathway	P00560	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00020	FAS signaling pathway	P00610	MKK4	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000022175|UniProtKB=F6XHY0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P05730	Endogenous cannabinoid signaling	P05751	Galpha	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00034	Integrin signalling pathway	P00951	Jnk	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000000931|UniProtKB=H2PZC4	Protein kinase N2	ISS	125549	gi	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00059	p53 pathway	P04610	Cyclin E	CHICK|Gene=CCNE1|UniProtKB=P49707	G1/S-specific cyclin-E1	NAS	12628165	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00016	Cytoskeletal regulation by Rho GTPase	P00518	Rho GEFs	HUMAN|HGNC=681|UniProtKB=Q92888	Rho guanine nucleotide exchange factor 1	ISS	12024019	PubMed	PTHR12673:SF122	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 1
P00036	Interleukin signaling pathway	P00973	PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00951	Jnk	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00018	EGF receptor signaling pathway	P00564	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DROME|FlyBase=FBgn0000043|UniProtKB=P02572	Actin-42A	ISS	14684598	PubMed	PTHR11937:SF369	ACTIN-42A
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	IC	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P06959	CCKR signaling map	P07079	p38MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	RCA	10600754	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00624	14-3-3	MACMU|Ensembl=ENSMMUG00000004125|UniProtKB=F6XLR8	14-3-3 protein gamma	ISS	99360936	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000008710|UniProtKB=F7E1W0	Uncharacterized protein	ISS	8120095	PubMed	PTHR43912:SF3	PROTOCADHERIN-1
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	TAKRU|Ensembl=ENSTRUG00000010978|UniProtKB=H2TSP4	Uncharacterized protein	ISS			PTHR10943:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2
P05918	p38 MAPK pathway	P06031	p38alpha	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	RCA	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P06959	CCKR signaling map	P07108	Caspase-3	HUMAN|HGNC=1504|UniProtKB=P42574	Caspase-3	RCA	18565785	PubMed	PTHR10454:SF198	CASPASE-3
P00018	EGF receptor signaling pathway	P00539	14-3-3	PLAF7|EnsemblGenome=MAL8P1.69|UniProtKB=C0H4V6	14-3-3 protein	ISS	99404831	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P05913	Enkephalin release	P05974	G-Protein (i)	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	IC	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01067	AChE	CANLF|Ensembl=ENSCAFG00000014054|UniProtKB=E2RP98	Carboxylic ester hydrolase	ISS	87080761	PubMed	PTHR11559:SF356	ACETYLCHOLINESTERASE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	18021322	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00047	PDGF signaling pathway	P01154	Ras	SCLS1|EnsemblGenome=SS1G_13801|UniProtKB=A7F871	Uncharacterized protein	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00004	Alzheimer disease-presenilin pathway	P00114	actin	XENTR|GeneID=394982|UniProtKB=P20399	Actin, alpha cardiac muscle 2	ISS	11889139	PubMed	PTHR11937:SF263	ACTIN
P00029	Huntington disease	P00772	FIP-2	MACMU|Ensembl=ENSMMUG00000017684|UniProtKB=F7CJ63	Uncharacterized protein	ISS			PTHR12757:SF3	TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 8
P00045	Notch signaling pathway	P01120	NIcs	PANTR|Ensembl=ENSPTRG00000010617|UniProtKB=H2QFL8	Notch 3	ISS	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00029	Huntington disease	G01531	BDNF	ORNAN|Ensembl=ENSOANG00000013030|UniProtKB=O02795	Brain-derived neurotrophic factor (Fragment)	ISS	12117585	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00050	Plasminogen activating cascade	P01260	pro-MMP-3	MOUSE|MGI=MGI=97010|UniProtKB=P28862	Stromelysin-1	ISS	3875482	PubMed	PTHR10201:SF215	STROMELYSIN-1
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IGI	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02729	Ascorbate degradation	P02852	L-xylulose-5-phosphate-3-epimerase	ARATH|TAIR=AT1G63290|UniProtKB=Q9C8T3	Ribulose-phosphate 3-epimerase	ISS			PTHR11749:SF3	RIBULOSE-PHOSPHATE 3-EPIMERASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ANOGA|EnsemblGenome=AGAP011036|UniProtKB=A0NBA9	AGAP011036-PA (Fragment)	ISS			PTHR10048:SF64	LD28067P
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	BOVIN|Ensembl=ENSBTAG00000003762|UniProtKB=A5PJS1	GNB5 protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05730	Endogenous cannabinoid signaling	P05743	CB1	BOVIN|Ensembl=ENSBTAG00000046006|UniProtKB=G5E6R9	Uncharacterized protein	ISS	114610	OMIM	PTHR22750:SF47	CANNABINOID RECEPTOR 1
P00048	PI3 kinase pathway	P01190	PDK1 ACT	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00022	General transcription by RNA polymerase I	P00651	TAF-IA	DROME|FlyBase=FBgn0022724|UniProtKB=Q9VWY6	Transcription initiation factor TFIID subunit 8	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P02734	Chorismate biosynthesis	P02874	Shikimate kinase	AQUAE|EnsemblGenome=aq_2177|UniProtKB=O67925	Shikimate kinase	ISS			PTHR21087:SF0	SHIKIMATE KINASE 1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=109356|UniProtKB=O09044	Synaptosomal-associated protein 23	IC	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00034	Integrin signalling pathway	P00916	Ras	DICDI|dictyBase=DDB_G0293434|UniProtKB=P15064	Ras-like protein rasG	IPI	89128893	PubMed	PTHR24070:SF282	RAS GTPASE-RELATED
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01154	Ras	CHICK|Ensembl=ENSGALG00000016485|UniProtKB=O93468	GTP-binding protein	ISS	13679859	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IDA	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05916	Opioid prodynorphin pathway	P06002	G-protein	ORNAN|Ensembl=ENSOANG00000013961|UniProtKB=F6VPY1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	BACSU|EnsemblGenome=BSU22730|UniProtKB=P31103	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00012	Cadherin signaling pathway	P00470	F-actin	DANRE|ZFIN=ZDB-GENE-030131-1229|UniProtKB=Q6DHS1	Actin, alpha 2, smooth muscle, aorta	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00012	Cadherin signaling pathway	P00470	F-actin	CANLF|Ensembl=ENSCAFG00000008756|UniProtKB=F2Z4N8	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P02747	Histidine biosynthesis	P02984	Imidazol glycerol phosphate dehydratase	BACSU|EnsemblGenome=BSU34900|UniProtKB=O34683	Imidazoleglycerol-phosphate dehydratase	ISS			PTHR23133:SF2	IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=4593|UniProtKB=Q13255	Metabotropic glutamate receptor 1	IDA			PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00017	DNA replication	P00529	RFC	RAT|RGD=621198|UniProtKB=Q641W4	Replication factor C subunit 2	RCA			PTHR11669:SF5	REPLICATION FACTOR C SUBUNIT 2
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IGI	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	RCA	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00054	Toll receptor signaling pathway	P01369	MKK1	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05916	Opioid prodynorphin pathway	P05998	Kappa Receptor	BOVIN|Ensembl=ENSBTAG00000000914|UniProtKB=Q2KIP6	Kappa-type opioid receptor	ISS	11259498	PubMed	PTHR24229:SF1	KAPPA-TYPE OPIOID RECEPTOR
P00012	Cadherin signaling pathway	P00470	F-actin	TAKRU|Ensembl=ENSTRUG00000007989|UniProtKB=P68140	Actin, alpha skeletal muscle A	IC	10974003	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000022175|UniProtKB=F6XHY0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P02778	Sulfate assimilation	P03167	Sulfate adenylyltransferase	BOVIN|Ensembl=ENSBTAG00000003196|UniProtKB=F1N085	Uncharacterized protein	ISS			PTHR11055:SF16	BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE 2
P00053	T cell activation	P01300	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01173	STAT	DANRE|ZFIN=ZDB-GENE-980526-499|UniProtKB=Q6P943	Signal transducer and activator of transcription	ISS	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00045	Notch signaling pathway	P01120	NIcs	MOUSE|MGI=MGI=107471|UniProtKB=P31695	Neurogenic locus notch homolog protein 4	ISS	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P04371	5-Hydroxytryptamine biosynthesis	P04399	Tryptophan hydroxylase	RAT|RGD=3895|UniProtKB=P09810	Tryptophan 5-hydroxylase 1	ISS	14597720	PubMed	PTHR11473:SF23	TRYPTOPHAN 5-HYDROXYLASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00089	Pen-2	MOUSE|MGI=MGI=1913590|UniProtKB=Q9CQR7	Gamma-secretase subunit PEN-2	IDA	12110170	PubMed	PTHR16318:SF0	GAMMA-SECRETASE SUBUNIT PEN-2
P00018	EGF receptor signaling pathway	P00540	MKK3,6	HUMAN|HGNC=6843|UniProtKB=P46734	Dual specificity mitogen-activated protein kinase kinase 3	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00018	EGF receptor signaling pathway	P00546	GAP	MACMU|Ensembl=ENSMMUG00000008605|UniProtKB=F6UAM4	Uncharacterized protein	ISS	8982875	PubMed	PTHR10194:SF60	NEUROFIBROMIN
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	XENTR|Xenbase=XB-GENE-1009691|UniProtKB=F6UWE1	Uncharacterized protein	ISS			PTHR11606:SF13	GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL
P04395	Vasopressin synthesis	P04593	Glycopeptide	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	IC	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8972|UniProtKB=O00750	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00053	T cell activation	P01305	Calmodulin	CAEEL|WormBase=WBGene00000552|UniProtKB=O16305	Calmodulin	ISS			PTHR23050:SF236	CALMODULIN
P00029	Huntington disease	P00807	Actin	DANRE|ZFIN=ZDB-GENE-040625-35|UniProtKB=Q6IQL9	Novel actin protein	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00051	TCA cycle	P01269	alphaketoglutarate Dehydrogenase	BACSU|EnsemblGenome=BSU19370|UniProtKB=P23129	2-oxoglutarate dehydrogenase E1 component	ISS	1508153	PubMed	PTHR23152:SF21	2-OXOGLUTARATE DEHYDROGENASE E1 COMPONENT DHKTD1, MITOCHONDRIAL-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00010	B cell activation	P00381	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	TAS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00009	Axon guidance mediated by netrin	P00359	NFAT	MACMU|Ensembl=ENSMMUG00000021843|UniProtKB=F6RNI3	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	ANOGA|EnsemblGenome=AGAP011806|UniProtKB=Q7PV11	AGAP011806-PA (Fragment)	ISS			PTHR11482:SF6	ORNITHINE DECARBOXYLASE 1-RELATED
P05913	Enkephalin release	P05972	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	PHYPA|Gene=PHYPADRAFT_185037|UniProtKB=A9SHH7	Predicted protein	ISS	3885394	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	CHICK|Gene=CHRM3|UniProtKB=P49578	Muscarinic acetylcholine receptor M3	ISS	11166329	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P02783	Tryptophan biosynthesis	P03211	Phosphribosyl anthranilate isomerase	CHLTR|EnsemblGenome=CT_327|UniProtKB=O84331	N-(5'-phosphoribosyl)anthranilate isomerase	ISS			PTHR42894:SF1	N- 5'-PHOSPHORIBOSYL ANTHRANILATE ISOMERASE
P00003	Alzheimer disease-amyloid secretase pathway	P00079	alpha7 nicotinic acetylcholine receptor	MOUSE|MGI=MGI=99779|UniProtKB=P49582	Neuronal acetylcholine receptor subunit alpha-7	IDA	85270494	PubMed	PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P00006	Apoptosis signaling pathway	P00321	HSP70	PANTR|Ensembl=ENSPTRG00000029754|UniProtKB=H2R7H0	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF210	HEAT SHOCK 70 KDA PROTEIN 1-LIKE
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000003399|UniProtKB=H2Q383	Phosphoinositide-3-kinase, class 2, alpha polypeptide	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	RCA	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00010	B cell activation	P00402	Jnk	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05913	Enkephalin release	P05972	PKA	STRPU|EnsemblGenome=SPU_018419|UniProtKB=W4YRI6	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DROME|FlyBase=FBgn0000489|UniProtKB=P16912	Protein kinase DC2	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00005	Angiogenesis	P00243	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	12068308	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05917	Opioid proopiomelanocortin pathway	P06006	beta-Endorphin	MONDO|Ensembl=ENSMODG00000015853|UniProtKB=Q95J84	Proopiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00057	Wnt signaling pathway	P01456	beta-arrestin	PANTR|Ensembl=ENSPTRG00000008601|UniProtKB=H2QBY1	Arrestin, beta 2	ISS	4757780	gi	PTHR11792:SF20	BETA-ARRESTIN-2
P05912	Dopamine receptor mediated signaling pathway	P05951	CDK5	TAKRU|Ensembl=ENSTRUG00000004034|UniProtKB=H2SAY8	Uncharacterized protein	ISS	10604473	PubMed	PTHR24056:SF46	CYCLIN-DEPENDENT-LIKE KINASE 5
P00047	PDGF signaling pathway	P01152	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	CHICK|Ensembl=ENSGALG00000002859|UniProtKB=F6UBD2	Uncharacterized protein	ISS	15470041	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	RAT|RGD=2520|UniProtKB=P61169	D(2) dopamine receptor	ISS	1319557	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P05912	Dopamine receptor mediated signaling pathway	P05964	GNAZ	PANTR|Ensembl=ENSPTRG00000014135|UniProtKB=H2QLC1	Uncharacterized protein	ISS	16814816	PubMed	PTHR10218:SF65	GUANINE NUCLEOTIDE-BINDING PROTEIN G Z  SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00049	Parkinson disease	P01208	Hsp70	CHICK|Ensembl=ENSGALG00000011715|UniProtKB=Q7SX63	Heat shock protein 70	IDA	12150907	PubMed	PTHR19375:SF216	HEAT SHOCK-RELATED 70 KDA PROTEIN 2
P00059	p53 pathway	P04609	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	12464394	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00021	FGF signaling pathway	P00634	MEKK1-5	BOVIN|Ensembl=ENSBTAG00000020079|UniProtKB=F1N3T0	Uncharacterized protein	ISS	602425	OMIM	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00010	B cell activation	P00402	Jnk	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IDA	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00059	p53 pathway	P04609	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Ensembl=ENSPTRG00000018449|UniProtKB=H2QTG5	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P06664	Gonadotropin-releasing hormone receptor pathway	P06786	ERK1/2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	RCA	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00060	Ubiquitin proteasome pathway	P01491	E2	SCHPO|PomBase=SPBC1105.09|UniProtKB=Q9Y818	Ubiquitin-conjugating enzyme E2 15	ISS			PTHR24067:SF3	UBIQUITIN-CONJUGATING ENZYME E2 G1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00035	Interferon-gamma signaling pathway	P00960	PTP	BOVIN|Ensembl=ENSBTAG00000002048|UniProtKB=F1N339	Tyrosine-protein phosphatase non-receptor type	ISS	8096088	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P04398	p53 pathway feedback loops 2	P04657	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04558	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00040	Metabotropic glutamate receptor group II pathway	P01052	AC	RAT|RGD=708450|UniProtKB=Q9Z286	Adenylate cyclase type 10	ISS	9874775	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MOUSE|MGI=MGI=102522|UniProtKB=Q8R3Z5	Voltage-dependent L-type calcium channel subunit beta-1	IDA	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00036	Interleukin signaling pathway	P00989	Ets	HUMAN|Ensembl=ENSG00000142539|UniProtKB=M0R3H8	Uncharacterized protein (Fragment)	TAS	8970723	PubMed	PTHR11849:SF174	TRANSCRIPTION FACTOR SPI-B
P00047	PDGF signaling pathway	P01160	IP3 receptor	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	TAS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00808	Caspase 8	RAT|RGD=620945|UniProtKB=Q9JHX4	Caspase-8	IDA	11788820	PubMed	PTHR10454:SF162	CASPASE-8
P00057	Wnt signaling pathway	P01471	alpha-catenin	MACMU|Ensembl=ENSMMUG00000000293|UniProtKB=F6YFG3	Uncharacterized protein	ISS	1638632	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P00012	Cadherin signaling pathway	P00470	F-actin	STRPU|EnsemblGenome=SPU_026078|UniProtKB=W4ZD41	Uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF277	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	HUMAN|HGNC=15781|UniProtKB=Q494W8	CHRNA7-FAM7A fusion protein	ISS	11404397	PubMed	PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	RAT|RGD=3784|UniProtKB=P61265	Syntaxin-1B	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00057	Wnt signaling pathway	P01444	Wnt	BOVIN|Ensembl=ENSBTAG00000015364|UniProtKB=E1BEN9	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02740	De novo pyrimidine ribonucleotides biosythesis	P02926	Aspartate carbamoyltransferase	STRCO|EnsemblGenome=CAB93367|UniProtKB=Q9KXR2	Aspartate carbamoyltransferase	ISS			PTHR11405:SF16	ASPARTATE CARBAMOYLTRANSFERASE, CHLOROPLASTIC
P04396	Vitamin D metabolism and pathway	P04601	25-Hydroxylase	BOVIN|Ensembl=ENSBTAG00000016906|UniProtKB=E1BN35	Uncharacterized protein	ISS	10232681	PubMed	PTHR24291:SF3	25-HYDROXYVITAMIN D-1 ALPHA HYDROXYLASE, MITOCHONDRIAL
P00047	PDGF signaling pathway	P01154	Ras	MOUSE|MGI=MGI=2665139|UniProtKB=Q8R367	Ras-related and estrogen-regulated growth inhibitor	ISS			PTHR24070:SF373	RAS-RELATED AND ESTROGEN-REGULATED GROWTH INHIBITOR
P00011	Blood coagulation	P00404	PAR-1	RAT|RGD=2586|UniProtKB=P26824	Proteinase-activated receptor 1	ISS	2506485	gi	PTHR24232:SF20	PROTEINASE-ACTIVATED RECEPTOR 1
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g161273|UniProtKB=A7RPJ6	Predicted protein	ISS	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00038	JAK/STAT signaling pathway	P01034	Jak	MOUSE|MGI=MGI=96629|UniProtKB=Q62120	Tyrosine-protein kinase JAK2	ISS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	CHICK|Ensembl=ENSGALG00000008898|UniProtKB=F1P2J9	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00005	Angiogenesis	P00206	Wnt	CHICK|Ensembl=ENSGALG00000014235|UniProtKB=Q3L254	Protein Wnt-7b	ISS	8717036	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00006	Apoptosis signaling pathway	P00297	NFkappaB	CANLF|Ensembl=ENSCAFG00000010155|UniProtKB=E2RLL2	Uncharacterized protein	ISS	9133421	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00811	Arp2/3 complex	CAEBR|Gene=CBG18174|UniProtKB=A8XT67	Protein CBR-ARX-3	ISS	12932731	PubMed	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P00057	Wnt signaling pathway	P01443	Phospholipase C	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	IDA	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000000985|UniProtKB=F6VRS9	Phosphoinositide phospholipase C	ISS			PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00010	B cell activation	P00375	Calmodulin	BRAFL|Gene=BRAFLDRAFT_87235|UniProtKB=C3ZEV9	Putative uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00078	Alpha1A/1B/1C	BOVIN|Gene=ADRA1A|UniProtKB=P18130	Alpha-1A adrenergic receptor	IC	6323229	PubMed	PTHR24248:SF16	ALPHA-1A ADRENERGIC RECEPTOR
P00034	Integrin signalling pathway	P00920	SOS	DROME|FlyBase=FBgn0001965|UniProtKB=P26675	Protein son of sevenless	IPI	8479536	PubMed	PTHR23113:SF99	PROTEIN SON OF SEVENLESS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00023	General transcription regulation	P00661	TTF2	RAT|RGD=621318|UniProtKB=Q9EPI8	Transcription termination factor 1, mitochondrial	ISS			PTHR15437:SF2	TRANSCRIPTION TERMINATION FACTOR 1, MITOCHONDRIAL
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000014751|UniProtKB=H2R8D8	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P05913	Enkephalin release	P05974	G-Protein (i)	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	CANLF|Ensembl=ENSCAFG00000010871|UniProtKB=F1PXA0	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00048	PI3 kinase pathway	P01194	S6K	XENTR|Xenbase=XB-GENE-482409|UniProtKB=F6UK84	Uncharacterized protein (Fragment)	ISS	15116068	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00023	General transcription regulation	P00669	TFIIEalpha	CANLF|Ensembl=ENSCAFG00000011306|UniProtKB=E2R3P2	Uncharacterized protein	ISS	189962	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00010	B cell activation	P00384	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IDA	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	STRCO|EnsemblGenome=CAB75393|UniProtKB=P50589	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	RCA	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00775	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12176041	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00012	Cadherin signaling pathway	P00475	Frizzled	DANRE|ZFIN=ZDB-GENE-990415-218|UniProtKB=B3DIG4	Frizzled homolog 8c	IDA	8717036	PubMed	PTHR11309:SF126	FRIZZLED-5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00038	JAK/STAT signaling pathway	P01034	Jak	MACMU|Ensembl=ENSMMUG00000014558|UniProtKB=F7GT47	Tyrosine-protein kinase	ISS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	IC	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00060	Ubiquitin proteasome pathway	P01491	E2	BOVIN|Ensembl=ENSBTAG00000046657|UniProtKB=G3MXY4	Uncharacterized protein	ISS			PTHR24068:SF48	UBIQUITIN-CONJUGATING ENZYME E2 D3
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00010	B cell activation	P00380	fos	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	TAS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00005	Angiogenesis	P00226	Delta/Serrate	MOUSE|MGI=MGI=1095416|UniProtKB=Q9QXX0	Protein jagged-1	ISS	8955070	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P02751	Lysine biosynthesis	P03012	N-succinyl-diaminopimelate desuccinylase	PYRAE|EnsemblGenome=PAE2335|UniProtKB=Q8ZVD7	Possible succinyl-diaminopimelate desuccinylase	ISS			PTHR43808:SF3	ACETYLORNITHINE DEACETYLASE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	CANLF|Ensembl=ENSCAFG00000010476|UniProtKB=F1PS94	Uncharacterized protein	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00036	Interleukin signaling pathway	P00996	STAT	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00046	Oxidative stress response	P01121	MKK3/6	MONDO|Ensembl=ENSMODG00000001404|UniProtKB=F7BD74	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00006	Apoptosis signaling pathway	P00295	Caspase 10	HUMAN|HGNC=1500|UniProtKB=Q92851	Caspase-10	IDA	8755496	PubMed	PTHR10454:SF26	CASPASE-10
P00021	FGF signaling pathway	P00629	PP2A	SCHMA|EnsemblGenome=Smp_165490|UniProtKB=C1LZY9	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00545	JNK1-3	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MOUSE|MGI=MGI=1313278|UniProtKB=Q9R216	Frizzled-9	TAS	11212302	PubMed	PTHR11309:SF79	FRIZZLED-9
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00036	Interleukin signaling pathway	P00990	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	IXOSC|EnsemblGenome=ISCW009711|UniProtKB=B7Q3T6	THO complex subunit, putative	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	PYRAE|EnsemblGenome=PAE2867|UniProtKB=O93730	Acetyl-coenzyme A synthetase	ISS			PTHR24095:SF232	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IC	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01465	Ggamma	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00037	Ionotropic glutamate receptor pathway	P01001	KA4	PANTR|Gene=GRIK4|UniProtKB=Q5IS46	Glutamate receptor ionotropic, kainate 4	ISS	1648176	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00048	PI3 kinase pathway	P01192	p110	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00561	STAT	TAKRU|Ensembl=ENSTRUG00000015348|UniProtKB=H2UQK9	Signal transducer and activator of transcription	ISS	11879641	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	CANLF|Ensembl=ENSCAFG00000010476|UniProtKB=F1PS94	Uncharacterized protein	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00881	ROCK	HUMAN|HGNC=10251|UniProtKB=Q13464	Rho-associated protein kinase 1	ISS	10779382	PubMed	PTHR22988:SF33	RHO-ASSOCIATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00562	p38	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00021	FGF signaling pathway	P00644	p38	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	CANLF|Ensembl=ENSCAFG00000007780|UniProtKB=F1PZH9	Uncharacterized protein	ISS	12441358	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00021	FGF signaling pathway	P00627	ERK1-2	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P02770	Pyridoxal phosphate salvage pathway	P03122	Pyridoxamine kinase	PSEAE|EnsemblGenome=PA5516|UniProtKB=Q9HT57	Pyridoxal kinase PdxY	ISS	10984043	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00057	Wnt signaling pathway	P01435	SWI/SNF	DICDI|dictyBase=DDB_G0277033|UniProtKB=Q550R6	Myb domain-containing protein	ISS	11532957	PubMed	PTHR12802:SF41	BRAHMA ASSOCIATED PROTEIN 155 KDA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01192	p110	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	RAT|RGD=2246|UniProtKB=Q07652	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	8386525	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	RAT|RGD=621353|UniProtKB=P08082	Clathrin light chain B	ISS	11889126	PubMed	PTHR10639:SF2	CLATHRIN LIGHT CHAIN B
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	RAT|RGD=3188|UniProtKB=Q9QW30	Neurogenic locus notch homolog protein 2	IDA	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00037	Ionotropic glutamate receptor pathway	P01026	KA	TAKRU|Ensembl=ENSTRUG00000009259|UniProtKB=H2TF39	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00557	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00049	Parkinson disease	P01230	Src kinase	DANRE|ZFIN=ZDB-GENE-050706-89|UniProtKB=F1RDG9	Tyrosine-protein kinase fynb	ISS	11078745	PubMed	PTHR24418:SF242	TYROSINE-PROTEIN KINASE FYNB
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00206	Wnt	MACMU|Ensembl=ENSMMUG00000000180|UniProtKB=F7HJM7	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00057	Wnt signaling pathway	P01443	Phospholipase C	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	IDA	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008422|UniProtKB=F6VUT7	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	ISS	8836152	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000014751|UniProtKB=H2R8D8	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	21071228	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	IC	8838318	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00012	Cadherin signaling pathway	P00462	Casein kinase II	DROME|FlyBase=FBgn0026136|UniProtKB=O96863	Casein kinase II subunit beta'	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	PANTR|Ensembl=ENSPTRG00000004079|UniProtKB=H2R1Z2	Uncharacterized protein	ISS	11742073	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00010	B cell activation	P00380	fos	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	TAS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	PANTR|Ensembl=ENSPTRG00000007682|UniProtKB=H2QAF3	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF142	MATRIX METALLOPROTEINASE-25
P00034	Integrin signalling pathway	P00944	Actin	HUMAN|HGNC=132|UniProtKB=P60709	Actin, cytoplasmic 1	IPI	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00019	Endothelin signaling pathway	P00589	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P02728	Arginine biosynthesis	P02846	Ornithine carbamoyl transferase	AQUAE|EnsemblGenome=aq_1711|UniProtKB=O67607	Ornithine carbamoyltransferase	ISS			PTHR11405:SF1	ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CANLF|Ensembl=ENSCAFG00000002617|UniProtKB=E2QUL1	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00012	Cadherin signaling pathway	P00470	F-actin	DROME|FlyBase=FBgn0000042|UniProtKB=P10987	Actin-5C	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00017	DNA replication	P00529	RFC	METAC|EnsemblGenome=MA_0266|UniProtKB=Q8TU09	tRNA-splicing ligase RtcB	ISS			PTHR11118:SF1	TRNA-SPLICING LIGASE RTCB HOMOLOG
P00052	TGF-beta signaling pathway	P01292	RSmads	CAEEL|WormBase=WBGene00000904|UniProtKB=Q21733	Dwarfin sma	TAS	9395284	PubMed	PTHR13703:SF25	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3
P00012	Cadherin signaling pathway	P00470	F-actin	CAEBR|Gene=CBG02161|UniProtKB=A8WS32	Protein CBG02161	ISS	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00010	B cell activation	P00398	IP3R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	RAT|RGD=3188|UniProtKB=Q9QW30	Neurogenic locus notch homolog protein 2	IDA	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00029	Huntington disease	P00810	GAPDH	LEPIN|EnsemblGenome=LA_1704|UniProtKB=Q8F5H7	Glyceraldehyde-3-phosphate dehydrogenase	ISS			PTHR10836:SF76	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE A
P00018	EGF receptor signaling pathway	P00564	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	10540223	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01219	SAPK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	NAS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00936	PI3K	CANAL|CGD=CAL0068551|UniProtKB=Q5AAR9	Phosphatidylinositol 3-kinase	IC	10870104	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01437	TCF	XENTR|Xenbase=XB-GENE-485517|UniProtKB=F6WCX0	Uncharacterized protein	ISS	11266476	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	PANTR|Ensembl=ENSPTRG00000034379|UniProtKB=H2RDK4	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CAEBR|Gene=CBG23090|UniProtKB=A8Y4R0	Protein CBG23090	ISS	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00045	Notch signaling pathway	P01115	Neurotic	HUMAN|HGNC=4019|UniProtKB=Q9BYC5	Alpha-(1,6)-fucosyltransferase	ISS			PTHR13132:SF29	ALPHA- 1,6 -FUCOSYLTRANSFERASE
P00053	T cell activation	P01312	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00049	Parkinson disease	P01220	Ubc7	DROME|FlyBase=FBgn0267384|UniProtKB=Q9VXE8	RE34144p	TAS	12859888	PubMed	PTHR24067:SF154	UBIQUITIN-CONJUGATING ENZYME E2 G2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BOVIN|Ensembl=ENSBTAG00000005714|UniProtKB=Q3ZC07	Actin, alpha cardiac muscle 1	ISS	3487386	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IGI	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00049	Parkinson disease	P01232	CASK	BOVIN|Ensembl=ENSBTAG00000020136|UniProtKB=A5D7B9	CASK protein	ISS	11679592	PubMed	PTHR23122:SF40	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00054	Toll receptor signaling pathway	P01346	TLR	RAT|RGD=1563357|UniProtKB=A5H2Z9	Protein Tlr7	ISS			PTHR44312:SF1	TOLL-LIKE RECEPTOR 7
P02784	Tyrosine biosynthesis	P03213	Aromatic amino acid aminotransferase	CAEEL|WormBase=WBGene00009628|UniProtKB=Q93703	Tyrosine AminoTraNsferase	ISS			PTHR11751:SF368	TYROSINE AMINOTRANSFERASE
P00046	Oxidative stress response	P01121	MKK3/6	CHICK|Ensembl=ENSGALG00000004735|UniProtKB=F1NHE1	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	TAS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01171	PLCgamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00049	Parkinson disease	P01208	Hsp70	PHYPA|Gene=PHYPADRAFT_226216|UniProtKB=A9TWR9	Predicted protein	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	MOUSE|MGI=MGI=1930705|UniProtKB=P61264	Syntaxin-1B	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00006	Apoptosis signaling pathway	P00311	GCKR	CHICK|Ensembl=ENSGALG00000012321|UniProtKB=F1NAN8	Mitogen-activated protein kinase kinase kinase kinase	ISS			PTHR24361:SF324	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04413	K+ channel	HUMAN|HGNC=6283|UniProtKB=Q9NPC2	Potassium channel subfamily K member 9	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P04397	p53 pathway by glucose deprivation	P04641	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00180	Dok-R	MOUSE|MGI=MGI=1351490|UniProtKB=Q9QZK7	Docking protein 3	ISS			PTHR21258:SF42	DOCKING PROTEIN 3
P00010	B cell activation	P00375	Calmodulin	MOUSE|MGI=MGI=103249|UniProtKB=P62204	Calmodulin	ISS	9753452	PubMed	PTHR23050:SF311	CALMODULIN
P00057	Wnt signaling pathway	P01465	Ggamma	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01188	Gbetagamma	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00017	DNA replication	P00532	Hel	MOUSE|MGI=MGI=2443732|UniProtKB=Q6ZQJ5	DNA replication ATP-dependent helicase/nuclease DNA2	RCA			PTHR10887:SF14	DNA REPLICATION ATP-DEPENDENT HELICASE/NUCLEASE DNA2
P00009	Axon guidance mediated by netrin	P00363	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MONDO|Ensembl=ENSMODG00000003363|UniProtKB=F7CB79	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT1G59580|UniProtKB=Q39022	Mitogen-activated protein kinase 2	IDA	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	RCA	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05730	Endogenous cannabinoid signaling	P05746	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00018	EGF receptor signaling pathway	P00547	PP2A	HUMAN|HGNC=9312|UniProtKB=Q14738	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	ISS	10092233	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00010	B cell activation	P00376	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00047	PDGF signaling pathway	P01160	IP3 receptor	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8718|UniProtKB=Q9Y5F6	Protocadherin gamma-C5	IDA	8120095	PubMed	PTHR24028:SF234	PROTOCADHERIN GAMMA-C5
P00001	Adrenaline and noradrenaline biosynthesis	P00067	MAO	RAT|RGD=3041|UniProtKB=P19643	Amine oxidase [flavin-containing] B	ISS	8602220	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	CAEEL|WormBase=WBGene00001607|UniProtKB=O02225	GLutamiNe synthetase (Glutamate-ammonia ligase)	ISS			PTHR20852:SF39	GLUTAMINE SYNTHETASE  GLUTAMATE-AMMONIA LIGASE
P04373	5HT1 type receptor mediated signaling pathway	P04409	5HT transporter	MACMU|Gene=SLC6A4|UniProtKB=Q9MYX0	Sodium-dependent serotonin transporter	ISS	14653308	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P00018	EGF receptor signaling pathway	P00558	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00029	Huntington disease	P00805	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	MACMU|Ensembl=ENSMMUG00000019351|UniProtKB=Q2YEG0	C-X-C chemokine receptor type 1	ISS	4504683	gi	PTHR10489:SF916	C-X-C CHEMOKINE RECEPTOR TYPE 1
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	RCA	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05734	Synaptic vesicle trafficking	P05778	SNAP-25	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	TAS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00025	Hedgehog signaling pathway	P00691	CBP	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00021	FGF signaling pathway	P00629	PP2A	DROME|FlyBase=FBgn0260439|UniProtKB=P36179	Serine/threonine-protein phosphatase PP2A 65 kDa regulatory subunit	ISS			PTHR10648:SF4	PROTEIN PHOSPHATASE 2  FORMERLY 2A , REGULATORY SUBUNIT A, BETA ISOFORM
P00029	Huntington disease	P00807	Actin	MOUSE|MGI=MGI=87902|UniProtKB=P68134	Actin, alpha skeletal muscle	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00005	Angiogenesis	P00190	RasGAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	ISS	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	MOUSE|MGI=MGI=97514|UniProtKB=P29121	Proprotein convertase subtilisin/kexin type 4	ISS			PTHR42884:SF16	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 4
P04384	Gamma-aminobutyric acid synthesis	P04482	Glutamate decarboxylase	DANRE|ZFIN=ZDB-GENE-030909-3|UniProtKB=F1Q5U5	Uncharacterized protein	ISS	2247446	PubMed	PTHR11999:SF57	GLUTAMATE DECARBOXYLASE 1
P04393	Ras Pathway	P04556	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00402	Jnk	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00049	Parkinson disease	P01221	Torsin A	HUMAN|HGNC=11996|UniProtKB=Q5JU69	Torsin-2A	IDA	12421356	PubMed	PTHR10760:SF4	TORSIN-2A
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00034	Integrin signalling pathway	P00926	GRAF	CHICK|Ensembl=ENSGALG00000007380|UniProtKB=Q5ZMW5	Rho GTPase-activating protein 26	ISS	8649427	PubMed	PTHR12552:SF4	RHO GTPASE-ACTIVATING PROTEIN 26
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	TAS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P06587	Nicotine pharmacodynamics pathway	P06613	CHRNB2	BOVIN|Ensembl=ENSBTAG00000007517|UniProtKB=F1MUN1	Uncharacterized protein	ISS	15155845	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	TAKRU|Ensembl=ENSTRUG00000002793|UniProtKB=H2S271	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF676	MYOSIN, HEAVY POLYPEPTIDE 2, FAST MUSCLE SPECIFIC
P00021	FGF signaling pathway	P00644	p38	CAEBR|Gene=CBG01555|UniProtKB=A8WRD7	Mitogen-activated protein kinase	ISS	22138445	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	IDA	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00047	PDGF signaling pathway	P01143	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00269	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	97449291	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00012	Cadherin signaling pathway	P00475	Frizzled	DANRE|ZFIN=ZDB-GENE-990415-223|UniProtKB=Q6NV44	Frizzled homolog 7a	IDA	11212302	PubMed	PTHR11309:SF31	FRIZZLED-7
P02738	De novo purine biosynthesis	P02902	ADP reductase	CHICK|Ensembl=ENSGALG00000016049|UniProtKB=F1P0T9	Uncharacterized protein	ISS			PTHR23409:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 B
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	ORNAN|Ensembl=ENSOANG00000009275|UniProtKB=F7EJA3	Uncharacterized protein	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00049	Parkinson disease	P01230	Src kinase	HUMAN|HGNC=4840|UniProtKB=P08631	Tyrosine-protein kinase HCK	IDA	11078745	PubMed	PTHR24418:SF245	TYROSINE-PROTEIN KINASE HCK
P00029	Huntington disease	P00774	Dynein complex	BOVIN|Ensembl=ENSBTAG00000025313|UniProtKB=Q3MHR3	Dynein light chain 2, cytoplasmic	ISS	9454836	PubMed	PTHR11886:SF35	DYNEIN LIGHT CHAIN 2, CYTOPLASMIC
P04398	p53 pathway feedback loops 2	P04661	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	ISS	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	RCA	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05923	beta-ARR2	MOUSE|MGI=MGI=99474|UniProtKB=Q91YI4	Beta-arrestin-2	RCA	4757780	gi	PTHR11792:SF20	BETA-ARRESTIN-2
P00059	p53 pathway	P04609	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01093	AChE	DANRE|ZFIN=ZDB-GENE-010906-1|UniProtKB=Q9DDE3	Acetylcholinesterase	ISS	87080761	PubMed	PTHR43918:SF3	ACETYLCHOLINESTERASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	MOUSE|MGI=MGI=99474|UniProtKB=Q91YI4	Beta-arrestin-2	IDA	12464600	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00048	PI3 kinase pathway	P01179	PKB	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00965	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	BOVIN|Ensembl=ENSBTAG00000002144|UniProtKB=Q28044	Beta-2 adrenergic receptor	IDA	7669252	PubMed	PTHR24248:SF21	BETA-2 ADRENERGIC RECEPTOR
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P02777	Succinate to proprionate conversion	P03161	Methylmalonyl-CoA mutase	STRCO|Gene=CAA22720|UniProtKB=Q9ZBK2	Coenzyme B12-dependent mutase	ISS			PTHR43589:SF3	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	RAT|RGD=1311928|UniProtKB=D3ZT83	Protein Slc1a7	ISS	96032356	PubMed	PTHR11958:SF22	EXCITATORY AMINO ACID TRANSPORTER 5
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00017	DNA replication	P00537	RPA	DANRE|ZFIN=ZDB-GENE-010131-3|UniProtKB=Q504I6	Rpa2 protein	ISS	14961282	PubMed	PTHR13989:SF16	RPA2 PROTEIN
P00034	Integrin signalling pathway	P00925	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00029	Huntington disease	P00807	Actin	PHYPA|Gene=PHYPADRAFT_172686|UniProtKB=A9TYG6	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00005	Angiogenesis	P00254	GTPase	CHICK|Ensembl=ENSGALG00000016485|UniProtKB=O93468	GTP-binding protein	ISS	13679859	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04393	Ras Pathway	P04563	Ets	MONDO|Ensembl=ENSMODG00000004730|UniProtKB=F6Y1Z2	Uncharacterized protein	ISS	3060801	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00057	Wnt signaling pathway	P01428	Frizzled	MACMU|Ensembl=ENSMMUG00000013215|UniProtKB=F6X7X4	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF31	FRIZZLED-7
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	HUMAN|HGNC=10431|UniProtKB=Q15349	Ribosomal protein S6 kinase alpha-2	ISS	1922062	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00983	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00030	Hypoxia response via HIF activation	P00819	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00034	Integrin signalling pathway	P00916	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00047	PDGF signaling pathway	P01148	Grb2	MONDO|Ensembl=ENSMODG00000000336|UniProtKB=F6VDE6	Uncharacterized protein	ISS			PTHR12156:SF18	GRB2-ASSOCIATED-BINDING PROTEIN 1
P00036	Interleukin signaling pathway	P00965	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=98329|UniProtKB=P30935	Somatostatin receptor type 3	IDA	12181435	PubMed	PTHR24229:SF42	SOMATOSTATIN RECEPTOR TYPE 3
P04393	Ras Pathway	P04559	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00562	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05913	Enkephalin release	P05974	G-Protein (i)	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00018	EGF receptor signaling pathway	P00561	STAT	MONDO|Ensembl=ENSMODG00000014816|UniProtKB=F7CHH2	Signal transducer and activator of transcription	ISS	96210005	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00029	Huntington disease	P00807	Actin	MOUSE|MGI=MGI=87904|UniProtKB=P60710	Actin, cytoplasmic 1	IDA	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000014498|UniProtKB=F7GEI8	Uncharacterized protein	ISS	14507926	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P04393	Ras Pathway	P04552	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00006	Apoptosis signaling pathway	P00274	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02738	De novo purine biosynthesis	P02902	ADP reductase	PYRAE|EnsemblGenome=PAE3155|UniProtKB=Q8ZTP7	Ribonucleotide reductase	ISS			PTHR43371:SF1	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00206	Wnt	BOVIN|Ensembl=ENSBTAG00000008097|UniProtKB=A4D7S0	Protein Wnt-2	ISS	11266476	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00005	Angiogenesis	P00228	Grb7	CANLF|Ensembl=ENSCAFG00000016328|UniProtKB=E2QZ71	Uncharacterized protein	ISS	10521483	PubMed	PTHR11243:SF25	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 7
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8666|UniProtKB=Q9UN75	Protocadherin alpha-12	IDA	8120095	PubMed	PTHR24028:SF76	PROTOCADHERIN ALPHA-12
P00057	Wnt signaling pathway	P01438	PP2A	HUMAN|HGNC=9300|UniProtKB=P62714	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	IDA	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	BOVIN|Ensembl=ENSBTAG00000005345|UniProtKB=Q3T035	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01238	14-3-3	MOUSE|MGI=MGI=891963|UniProtKB=P68254	14-3-3 protein theta	IDA	10407019	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00012	Cadherin signaling pathway	P00471	Cadherin	BOVIN|Ensembl=ENSBTAG00000011862|UniProtKB=G3X6Y5	Uncharacterized protein	ISS	8120095	PubMed	PTHR43912:SF7	PROTOCADHERIN-20
P00048	PI3 kinase pathway	P01179	PKB	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06849	Sos	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	RCA	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	MACMU|Ensembl=ENSMMUG00000006202|UniProtKB=F7HNP4	Excitatory amino acid transporter 1 isoform 1	ISS	94365697	PubMed	PTHR11958:SF24	EXCITATORY AMINO ACID TRANSPORTER 1
P00054	Toll receptor signaling pathway	P01375	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	STRCO|Gene=CAB90858|UniProtKB=Q7AKP2	Glutamine synthetase	ISS			PTHR20852:SF57	GLUTAMINE SYNTHETASE 2 CYTOPLASMIC
P00057	Wnt signaling pathway	P01448	CBP	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	IDA	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00025	Hedgehog signaling pathway	P00691	CBP	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	ARATH|TAIR=AT1G67220|UniProtKB=Q9FYH1	Histone acetyltransferase HAC2	TAS	10769018	PubMed	PTHR13808:SF6	HISTONE ACETYLTRANSFERASE HAC2
P05914	Nicotine degradation	P05982	UGT1A4	MACMU|Ensembl=ENSMMUG00000021216|UniProtKB=F7GW12	UDP-glucuronosyltransferase	ISS	12433823	PubMed	PTHR11926:SF173	UDP-GLUCURONOSYLTRANSFERASE 1-3-RELATED
P05915	Opioid proenkephalin pathway	P05994	G-protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DICDI|dictyBase=DDB_G0283903|UniProtKB=Q54QB1	Extracellular signal-regulated kinase 2	IDA	gi:1362216	gi	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00054	Toll receptor signaling pathway	P01369	MKK1	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00013	Cell cycle	P00480	Proteasome	CANLF|Ensembl=ENSCAFG00000016267|UniProtKB=E2QUY7	Uncharacterized protein	ISS	2568889	PubMed	PTHR10758:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	XENTR|Xenbase=XB-GENE-977853|UniProtKB=F7EBE7	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00056	VEGF signaling pathway	P01408	Akt/PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00566	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	XENTR|Ensembl=ENSXETG00000030140|UniProtKB=F7EP58	Uncharacterized protein (Fragment)	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00878	INFgamma	RAT|RGD=2866|UniProtKB=P01581	Interferon gamma	TAS	11175845	PubMed	PTHR11419:SF0	INTERFERON GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	CAEEL|WormBase=WBGene00001748|UniProtKB=P48727	Serine/threonine-protein phosphatase PP1-beta	ISS	8392016	PubMed	PTHR11668:SF402	SERINE/THREONINE-PROTEIN PHOSPHATASE
P02748	Isoleucine biosynthesis	P02998	Dihydroxyacid dehydratase	NEUCR|EnsemblGenome=EFNCRG00000007655|UniProtKB=Q7SBQ5	Dihydroxy-acid dehydratase	ISS			PTHR21000:SF13	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00561	STAT	MONDO|Ensembl=ENSMODG00000014816|UniProtKB=F7CHH2	Signal transducer and activator of transcription	ISS	22320921	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00015	Circadian clock system	G01497	cry	PANTR|Ensembl=ENSPTRG00000005396|UniProtKB=H2Q6S7	Cryptochrome 1 (Photolyase-like)	ISS	10217146	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	DANRE|Ensembl=ENSDARG00000024785|UniProtKB=B7ZC77	Catenin alpha-2	ISS	1638632	PubMed	PTHR18914:SF29	CATENIN ALPHA-2
P04393	Ras Pathway	P04552	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IDA	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00030	Hypoxia response via HIF activation	P00819	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01230	Src kinase	PANTR|Ensembl=ENSPTRG00000007282|UniProtKB=H2Q9T1	Tyrosine-protein kinase	ISS	12665526	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95809|UniProtKB=P23819	Glutamate receptor 2	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00030	Hypoxia response via HIF activation	P00819	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	RCA			PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IDA	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CANLF|Ensembl=ENSCAFG00000004381|UniProtKB=J9JH96	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	PYRAE|EnsemblGenome=PAE1917|UniProtKB=Q8ZW86	Pyrroline-5-carboxylate reductase	ISS			PTHR11645:SF0	PYRROLINE-5-CARBOXYLATE REDUCTASE
P02721	ATP synthesis	P02798	Cyt C	BOVIN|Ensembl=ENSBTAG00000025310|UniProtKB=E1BA13	Uncharacterized protein	TAS	5968568	PubMed	PTHR11961:SF15	CYTOCHROME C
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00056	VEGF signaling pathway	P01417	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	RCA	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-040718-134|UniProtKB=Q6DH55	Guanine nucleotide binding protein (G protein), beta polypeptide 3, like	ISS	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00018	EGF receptor signaling pathway	P00551	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00951	Jnk	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00046	Oxidative stress response	P01135	p38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00019	Endothelin signaling pathway	P00589	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	12655147	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	MACMU|Ensembl=ENSMMUG00000014130|UniProtKB=F7C1B5	Aldehyde dehydrogenase	ISS	14724059	PubMed	PTHR43570:SF9	FATTY ALDEHYDE DEHYDROGENASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	RAT|RGD=67399|UniProtKB=Q64716	Insulin receptor-related protein	ISS	11182407	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00029	Huntington disease	P00807	Actin	PANTR|Ensembl=ENSPTRG00000018890|UniProtKB=Q5R1X3	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00029	Huntington disease	P00796	Kainate receptor	BOVIN|Ensembl=ENSBTAG00000011723|UniProtKB=E1BKL6	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00045	Notch signaling pathway	P01110	Presenilin	CHICK|Ensembl=ENSGALG00000009320|UniProtKB=Q4JIM4	Presenilin-1	ISS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	PANTR|Ensembl=ENSPTRG00000019406|UniProtKB=H2QUX9	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF26	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT GAMMA-T1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00034	Integrin signalling pathway	P00931	Integrin beta	HUMAN|HGNC=6162|UniProtKB=P26010	Integrin beta-7	IDA	10741397	PubMed	PTHR10082:SF36	INTEGRIN BETA-7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00006	Apoptosis signaling pathway	P00260	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00470	F-actin	DROME|FlyBase=FBgn0000044|UniProtKB=P53501	Actin-57B	IC	10974003	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00046	Oxidative stress response	P01132	c-jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00037	Ionotropic glutamate receptor pathway	P01015	Glu4	PANTR|Ensembl=ENSPTRG00000004233|UniProtKB=H2Q4N9	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	ENTHI|EnsemblGenome=EHI_197840|UniProtKB=C4M8K6	Rho family GTPase	ISS	8649368	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02746	Heme biosynthesis	P02974	Uroporphyrinogen-III synthase	MACMU|Ensembl=ENSMMUG00000008539|UniProtKB=F6WBU8	Uncharacterized protein	ISS			PTHR12390:SF0	UROPORPHYRINOGEN-III SYNTHASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IC	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00001	Adrenaline and noradrenaline biosynthesis	P00068	amine translocator	HUMAN|HGNC=13621|UniProtKB=Q9H2J7	Sodium-dependent neutral amino acid transporter B(0)AT2	IC	12719981	PubMed	PTHR11616:SF101	SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER B 0 AT2
P00036	Interleukin signaling pathway	P00973	PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00049	Parkinson disease	P01212	p38 MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04393	Ras Pathway	P04547	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	DROME|FlyBase=FBgn0004168|UniProtKB=P28285	5-hydroxytryptamine receptor 2A	IDA			PTHR24247:SF117	5-HYDROXYTRYPTAMINE RECEPTOR 2A-RELATED
P00049	Parkinson disease	P01242	Casein kinase I	HUMAN|HGNC=2453|UniProtKB=P49674	Casein kinase I isoform epsilon	IDA	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00034	Integrin signalling pathway	P00907	ERK	MACMU|Ensembl=ENSMMUG00000016751|UniProtKB=F7AIB6	Mitogen-activated protein kinase kinase kinase 3 isoform 1	ISS			PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00056	VEGF signaling pathway	P01414	PLC-gamma	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00029	Huntington disease	P00807	Actin	TAKRU|Ensembl=ENSTRUG00000004787|UniProtKB=P53480	Actin, alpha cardiac	IDA	11889126	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P06664	Gonadotropin-releasing hormone receptor pathway	P06807	gnai	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	RCA	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00005	Angiogenesis	P00189	Fzd	PANTR|Ensembl=ENSPTRG00000012855|UniProtKB=H2QJA9	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF126	FRIZZLED-5
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	BOVIN|Ensembl=ENSBTAG00000011761|UniProtKB=F1MDE1	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00547	PP2A	MOUSE|MGI=MGI=2388481|UniProtKB=Q91V89	Protein Ppp2r5d	ISS	10092233	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00057	Wnt signaling pathway	P01457	GBeta	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	6264430	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00010	B cell activation	P00383	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	MYCTU|EnsemblGenome=LH57_10230|UniProtKB=O07752	Glutamine synthetase	ISS			PTHR43785:SF2	TYPE-1 GLUTAMINE SYNTHETASE 1
P00047	PDGF signaling pathway	P01167	Ets	MACMU|Ensembl=ENSMMUG00000014599|UniProtKB=F7GQ25	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF31	ETS DOMAIN-CONTAINING TRANSCRIPTION FACTOR ERF
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=7607|UniProtKB=Q6PIF6	Unconventional myosin-VIIb	IC			PTHR13140:SF505	UNCONVENTIONAL MYOSIN-VIIB
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02759	Pyridoxal-5-phosphate biosynthesis	P03061	Pyridoxine-5-phosphate oxidase	YEAST|SGD=S000000239|UniProtKB=P38075	Pyridoxamine 5'-phosphate oxidase	ISS	8849441	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00021	FGF signaling pathway	P00631	Grb2	DANRE|ZFIN=ZDB-GENE-040426-1975|UniProtKB=Q6PC73	Growth factor receptor-bound protein 2	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	HUMAN|HGNC=9871|UniProtKB=P20936	Ras GTPase-activating protein 1	TAS	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00048	PI3 kinase pathway	P01198	FOXO	BOVIN|Ensembl=ENSBTAG00000011234|UniProtKB=F1N4K5	Uncharacterized protein	ISS	12048180	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00010	B cell activation	P00398	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	MOUSE|MGI=MGI=1298218|UniProtKB=O88572	Low-density lipoprotein receptor-related protein 6	IDA	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00059	p53 pathway	P01486	Akt	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	TAS	21291563	gi	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P05918	p38 MAPK pathway	P06017	MNK2	MACMU|Ensembl=ENSMMUG00000011265|UniProtKB=F6WP09	Uncharacterized protein	ISS	9155017	PubMed	PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00702	CPB	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	RCA			PTHR13808:SF5	CREB-BINDING PROTEIN
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	DICDI|dictyBase=DDB_G0274569|UniProtKB=Q03101	Adenylate cyclase, germination specific	IGI	98054247	PubMed	PTHR11920:SF442	ADENYLATE CYCLASE, GERMINATION SPECIFIC
P00021	FGF signaling pathway	P00640	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00018	EGF receptor signaling pathway	P00561	STAT	HUMAN|HGNC=11368|UniProtKB=P42226	Signal transducer and activator of transcription 6	IGI	94367369	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=2144613|UniProtKB=Q3U6Q4	Phosphoinositide 3-kinase regulatory subunit 6	ISS			PTHR15593:SF1	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 6
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00010	B cell activation	P00384	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	IDA	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04393	Ras Pathway	P04578	Rho	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	IDA	10556059	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00021	FGF signaling pathway	P00624	14-3-3	MONDO|Ensembl=ENSMODG00000009856|UniProtKB=F6WA79	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P02734	Chorismate biosynthesis	P02873	Shikimate dehydrogenase	BACSU|EnsemblGenome=BSU25660|UniProtKB=P54374	Shikimate dehydrogenase (NADP(+))	ISS			PTHR21089:SF21	SUBFAMILY NOT NAMED
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00003	Alzheimer disease-amyloid secretase pathway	P00092	TACE	PANTR|Ensembl=ENSPTRG00000011640|UniProtKB=H2R900	Uncharacterized protein	ISS	9774383	PubMed	PTHR11905:SF171	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IGI	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00034	Integrin signalling pathway	P00924	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00187	beta catenin	PANTR|Ensembl=ENSPTRG00000023062|UniProtKB=H2R2U1	Catenin (Cadherin-associated protein), beta 1, 88kDa	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	RAT|RGD=70964|UniProtKB=Q62893	Anti-Muellerian hormone type-2 receptor	TAS	9759503	PubMed	PTHR23255:SF49	ANTI-MUELLERIAN HORMONE TYPE-2 RECEPTOR
P00029	Huntington disease	P00811	Arp2/3 complex	MOUSE|MGI=MGI=1915021|UniProtKB=Q9CPW4	Actin-related protein 2/3 complex subunit 5	ISS	9230079	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00048	PI3 kinase pathway	P01181	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00047	PDGF signaling pathway	P01160	IP3 receptor	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHICK|Ensembl=ENSGALG00000009844|UniProtKB=P68034	Actin, alpha cardiac muscle 1	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MOUSE|MGI=MGI=88397|UniProtKB=Q9ERZ4	Muscarinic acetylcholine receptor M2	TAS	12181435	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=17175|UniProtKB=Q9P212	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	12176394	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00054	Toll receptor signaling pathway	P01358	ERK1	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01323	I kappa B	CANLF|Ensembl=ENSCAFG00000013418|UniProtKB=E2RML9	Uncharacterized protein	ISS	14665694	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00053	T cell activation	P01307	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05918	p38 MAPK pathway	P06020	p38delta	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00012	Cadherin signaling pathway	P00470	F-actin	PLAF7|EnsemblGenome=PF14_0124|UniProtKB=Q8ILW9	Actin-2	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_206575|UniProtKB=E9FUX0	Guanine nucleotide binding protein, beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PHYPA|Gene=PHYPADRAFT_198730|UniProtKB=Q6TYS2	Actin 1	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000002674|UniProtKB=P02698	Guanine nucleotide-binding protein G(T) subunit gamma-T1	IDA	3100519	PubMed	PTHR13809:SF26	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT GAMMA-T1
P02774	Salvage pyrimidine deoxyribonucleotides	P03145	Uracil phosphorylase	DEIRA|EnsemblGenome=DR_0443|UniProtKB=Q9RX72	Pyrimidine-nucleoside phosphorylase	ISS	10567266	PubMed	PTHR10515:SF0	THYMIDINE PHOSPHORYLASE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02928	Dihydroorotase	DEIRA|EnsemblGenome=DR_1106|UniProtKB=Q9RVC3	Dihydroorotase	ISS			PTHR43668:SF1	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	MOUSE|MGI=MGI=95819|UniProtKB=P35438	Glutamate receptor ionotropic, NMDA 1	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	CIOIN|Ensembl=ENSCING00000000848|UniProtKB=F6SCP4	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	XENTR|Xenbase=XB-GENE-5752629|UniProtKB=F6UBB9	Uncharacterized protein	ISS	1840599	PubMed	PTHR10024:SF239	SYNAPTOTAGMIN-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	PANTR|Ensembl=ENSPTRG00000018684|UniProtKB=C7G3M7	Glutamate receptor, metabotropic 1	ISS	14614461	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00057	Wnt signaling pathway	P01451	Galpha	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	IDA	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00034	Integrin signalling pathway	P00943	Talin	MOUSE|MGI=MGI=1099832|UniProtKB=P26039	Talin-1	ISS	14702644	PubMed	PTHR19981:SF7	MESODERM DEVELOPMENT CANDIDATE 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	MACMU|Ensembl=ENSMMUG00000010707|UniProtKB=F7G8G5	Signal transducer and activator of transcription	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06830	AMPK	MOUSE|MGI=MGI=1336153|UniProtKB=Q91WG5	5'-AMP-activated protein kinase subunit gamma-2	RCA			PTHR13780:SF26	5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-2
P00012	Cadherin signaling pathway	P00474	Wnt	MONDO|Ensembl=ENSMODG00000012401|UniProtKB=F6PMQ6	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00030	Hypoxia response via HIF activation	P00823	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	10799299	PubMed	PTHR10048:SF14	PI-3 KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CHICK|Ensembl=ENSGALG00000014620|UniProtKB=F1N8P3	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P02775	Salvage pyrimidine ribonucleotides	P03149	Cytidine kinase	HUMAN|HGNC=12562|UniProtKB=Q9BZX2	Uridine-cytidine kinase 2	ISS			PTHR10285:SF70	URIDINE-CYTIDINE KINASE 2
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	IC	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	IC	8170357	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	XENTR|Xenbase=XB-GENE-494548|UniProtKB=F7EC26	Uncharacterized protein	ISS	10825661	PubMed	PTHR24070:SF186	GTPASE KRAS
P00052	TGF-beta signaling pathway	P01286	TGFbeta	DANRE|ZFIN=ZDB-GENE-050208-735|UniProtKB=Q68IN2	Growth differentiation factor 8, like	ISS			PTHR11848:SF235	GROWTH DIFFERENTIATION FACTOR 8, LIKE-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	DEIRA|EnsemblGenome=DR_0684|UniProtKB=Q9RWI4	Carbamoyl-phosphate synthase small chain	ISS			PTHR11405:SF4	CARBAMOYL-PHOSPHATE SYNTHASE ARGININE-SPECIFIC SMALL CHAIN
P04398	p53 pathway feedback loops 2	P04665	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	RAT|RGD=2025|UniProtKB=P68136	Actin, alpha skeletal muscle	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P05731	GABA-B receptor II signaling	P05758	K channel	ORNAN|Ensembl=ENSOANG00000006119|UniProtKB=F6WTY3	Uncharacterized protein	ISS	12374786	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CIOIN|Ensembl=ENSCING00000001377|UniProtKB=F6SDC9	Uncharacterized protein	ISS			PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	MOUSE|MGI=MGI=1341272|UniProtKB=Q80X19	Collagen alpha-1(XIV) chain	ISS	10778855	PubMed	PTHR44557:SF1	COLLAGEN ALPHA-1 XIV  CHAIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS			PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00023	General transcription regulation	P00668	TFIIB	DANRE|ZFIN=ZDB-GENE-040426-1784|UniProtKB=Q6PBJ2	Cilia- and flagella-associated protein 20	ISS			PTHR12458:SF8	CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01076	CAT	CANLF|Ensembl=ENSCAFG00000006672|UniProtKB=F1PR75	Uncharacterized protein	ISS	97225904	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	BOVIN|Ensembl=ENSBTAG00000019210|UniProtKB=F1MJV4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00011	Blood coagulation	P00414	Thrombin	CHICK|Ensembl=ENSGALG00000008332|UniProtKB=F1NXV6	Prothrombin	ISS	+176930	OMIM	PTHR24254:SF10	PROTHROMBIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=102643|UniProtKB=O08638	Myosin-11	IC	89264452	PubMed	PTHR13140:SF335	MYOSIN-11
P00005	Angiogenesis	P00223	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01305	Calmodulin	MACMU|Ensembl=ENSMMUG00000028962|UniProtKB=F7EWG5	Uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF322	SUBFAMILY NOT NAMED
P00060	Ubiquitin proteasome pathway	P01491	E2	ORNAN|Ensembl=ENSOANG00000006626|UniProtKB=F6Q430	Uncharacterized protein	ISS			PTHR43902:SF2	UBIQUITIN-CONJUGATING ENZYME E2 N
P00018	EGF receptor signaling pathway	P00547	PP2A	BRAFL|Gene=BRAFLDRAFT_123893|UniProtKB=C3XQF4	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	PANTR|Ensembl=ENSPTRG00000001056|UniProtKB=H2PZL0	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	STRCO|Gene=CAD30904|UniProtKB=Q9AD84	Putative aldehyde dehydrogenase	IC			PTHR11699:SF211	ALDEHYDE DEHYDROGENASE 5, MITOCHONDRIAL
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	10693759	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00174	CD44 N-terminal fragment	RAT|RGD=2307|UniProtKB=P26051	CD44 antigen	IDA	14871815	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P00015	Circadian clock system	G01501	cry	ORNAN|Ensembl=ENSOANG00000005350|UniProtKB=F6X852	Uncharacterized protein	ISS	11804325	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00047	PDGF signaling pathway	P01160	IP3 receptor	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00048	PI3 kinase pathway	P01192	p110	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	IC	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05913	Enkephalin release	P05972	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00897	SHIP2	PANTR|Ensembl=ENSPTRG00000004031|UniProtKB=H2Q4C6	Inositol polyphosphate phosphatase-like 1	ISS	12145149	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=102705|UniProtKB=P63213	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00006	Apoptosis signaling pathway	P00318	PKCs	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	CANLF|Gene=DRD2|UniProtKB=Q9GJU1	D(2) dopamine receptor	ISS	2039532	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P04397	p53 pathway by glucose deprivation	P04641	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00029	Huntington disease	P00807	Actin	BOVIN|Ensembl=ENSBTAG00000006189|UniProtKB=P63258	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P04398	p53 pathway feedback loops 2	P04651	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	TAS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00018	EGF receptor signaling pathway	P00552	Ras	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	IGI	12104050	PubMed	PTHR24070:SF189	GTPASE NRAS
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	RAT|RGD=620201|UniProtKB=O88272	Matrix metalloproteinase-23	TAS	12834808	PubMed	PTHR10201:SF7	MATRIX METALLOPROTEINASE-23
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PLAF7|EnsemblGenome=PFL2215w|UniProtKB=Q8I4X0	Actin-1	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02746	Heme biosynthesis	P02979	porphobilinogen synthase	PHYPA|Gene=PHYPADRAFT_221821|UniProtKB=Q43058	Delta-aminolevulinic acid dehydratase, chloroplastic	ISS			PTHR11458:SF0	DELTA-AMINOLEVULINIC ACID DEHYDRATASE
P00057	Wnt signaling pathway	P01443	Phospholipase C	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	IDA	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CANLF|Ensembl=ENSCAFG00000005291|UniProtKB=E2QXQ3	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00051	TCA cycle	P01271	Fumarase	SYNY3|EnsemblGenome=BAA10200|UniProtKB=Q55674	Fumarate hydratase class II	ISS	16331402	gi	PTHR11444:SF1	FUMARATE HYDRATASE, MITOCHONDRIAL
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DANRE|ZFIN=ZDB-GENE-010705-1|UniProtKB=Q90Z40	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00021	FGF signaling pathway	P00632	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	CAEEL|WormBase=WBGene00004769|UniProtKB=P52166	Presenilin sel-12	IDA	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00047	PDGF signaling pathway	P01161	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00059	p53 pathway	P01480	PTEN	DROME|FlyBase=FBgn0026379|UniProtKB=Q7KMQ6	IP16020p	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	HUMAN|HGNC=1078|UniProtKB=Q13873	Bone morphogenetic protein receptor type-2	TAS	9395284	PubMed	PTHR23255:SF63	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	TAS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00048	PI3 kinase pathway	G01543	IGFBP1	PANTR|Ensembl=ENSPTRG00000019165|UniProtKB=H2QUJ5	Uncharacterized protein	ISS	12493691	PubMed	PTHR11551:SF6	INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 1
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	G01530	HTT	HUMAN|HGNC=4851|UniProtKB=P42858	Huntingtin	IDA	8268927	PubMed	PTHR10170:SF10	HUNTINGTIN
P05916	Opioid prodynorphin pathway	P06002	G-protein	TAKRU|Ensembl=ENSTRUG00000011297|UniProtKB=H2TV18	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01067	AChE	BRAFL|Gene=BRAFLDRAFT_132597|UniProtKB=C3ZRW7	Carboxylic ester hydrolase	ISS	87080761	PubMed	PTHR11559:SF356	ACETYLCHOLINESTERASE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00023	General transcription regulation	P00660	RNA Polymerase II	MACMU|Ensembl=ENSMMUG00000020474|UniProtKB=F6VRF4	DNA-directed RNA polymerase II subunit RPB3	ISS	2187864	PubMed	PTHR11800:SF2	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	RAT|RGD=2349|UniProtKB=P25109	Acetylcholine receptor subunit beta	IC	22213672	PubMed	PTHR18945:SF477	ACETYLCHOLINE RECEPTOR SUBUNIT BETA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347736|UniProtKB=E9FRT1	Muscle-specific actin	ISS	11889126	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P04393	Ras Pathway	P04542	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00933	Crk	BOVIN|Ensembl=ENSBTAG00000005665|UniProtKB=E1BQ32	Uncharacterized protein	ISS	8649368	PubMed	PTHR19969:SF8	ADAPTER MOLECULE CRK
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	RAT|RGD=2744|UniProtKB=P31422	Metabotropic glutamate receptor 3	ISS	12488551	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00013	Cell cycle	P00484	Cyclin D	HUMAN|HGNC=1585|UniProtKB=P30281	G1/S-specific cyclin-D3	IEP	14576819	PubMed	PTHR10177:SF65	G1/S-SPECIFIC CYCLIN-D3
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	THEMA|EnsemblGenome=TM_1347|UniProtKB=Q9X168	Inosine-5'-monophosphate dehydrogenase	ISS			PTHR11911:SF6	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE
P02769	Purine metabolism	P03118	Guanine Deaminase	MOUSE|MGI=MGI=95678|UniProtKB=Q9R111	Guanine deaminase	ISS	11837778	gi	PTHR11271:SF6	GUANINE DEAMINASE
P00050	Plasminogen activating cascade	P01254	pro-MMP-13	PANTR|Ensembl=ENSPTRG00000004222|UniProtKB=H2Q4N4	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF165	COLLAGENASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	RCA	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01275	P38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00057	Wnt signaling pathway	P01448	CBP	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00053	T cell activation	P01312	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00091	Aph-1	HUMAN|HGNC=24080|UniProtKB=Q8WW43	Gamma-secretase subunit APH-1B	IDA	12763021	PubMed	PTHR12889:SF1	GAMMA-SECRETASE SUBUNIT APH-1B
P02768	Proline biosynthesis	P03112	Glutamate semialdehyde dehydrogenase	AQUAE|EnsemblGenome=aq_1071|UniProtKB=O67166	Gamma-glutamyl phosphate reductase	ISS			PTHR11063:SF8	DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE
P00012	Cadherin signaling pathway	P00467	alpha-catenin	BOVIN|Gene=CTNNA1|UniProtKB=Q3MHM6	Catenin alpha-1	ISS	10456847	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IGI	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1203729|UniProtKB=Q61194	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P05916	Opioid prodynorphin pathway	P06001	AC	RAT|RGD=619965|UniProtKB=P26769	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00006	Apoptosis signaling pathway	P00269	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04665	AKT	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02763	Peptidoglycan biosynthesis	P03083	UDP-N-acetylmuramoylalanine-D-glutamate ligase	THEMA|EnsemblGenome=TM_0234|UniProtKB=Q9WY76	UDP-N-acetylmuramoylalanine--D-glutamate ligase	ISS			PTHR43692:SF1	UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE
P00051	TCA cycle	P01274	Succinyl CoA Synthetase	BOVIN|Gene=SUCLG1|UniProtKB=Q58DR8	Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial	ISS	97407896	PubMed	PTHR11117:SF2	SUCCINYL-COA LIGASE  ADP/GDP-FORMING  SUBUNIT ALPHA, MITOCHONDRIAL
P00054	Toll receptor signaling pathway	P01369	MKK1	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT1G59580|UniProtKB=Q39022	Mitogen-activated protein kinase 2	ISS	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00059	p53 pathway	P04628	14-3-3	CANLF|Ensembl=ENSCAFG00000012290|UniProtKB=F1PQ93	Uncharacterized protein	ISS			PTHR18860:SF14	14-3-3 PROTEIN SIGMA
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00049	Parkinson disease	P01231	gamma-Synuclein	XENTR|Xenbase=XB-GENE-973674|UniProtKB=Q28F65	Gamma-synuclein	ISS			PTHR13820:SF10	GAMMA-SYNUCLEIN
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	MOUSE|MGI=MGI=94925|UniProtKB=P30728	D(3) dopamine receptor	ISS	2039532	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00047	PDGF signaling pathway	P01161	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04564	MAPKAP	PANTR|Ensembl=ENSPTRG00000014968|UniProtKB=H2QMP5	Mitogen-activated protein kinase-activated protein kinase 3	ISS	11157753	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P00012	Cadherin signaling pathway	P00476	Yes	CANLF|Gene=YES1|UniProtKB=Q28923	Tyrosine-protein kinase Yes	ISS	11078745	PubMed	PTHR24418:SF90	TYROSINE-PROTEIN KINASE YES
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00005	Angiogenesis	P00200	Dsh	PANTR|Gene=DVL1|UniProtKB=Q5IS48	Segment polarity protein dishevelled homolog DVL-1	ISS	7906389	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P00047	PDGF signaling pathway	P01160	IP3 receptor	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00057	Wnt signaling pathway	P01444	Wnt	CHICK|Ensembl=ENSGALG00000005123|UniProtKB=Q9DEB8	Protein Wnt	IDA	8717036	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00052	TGF-beta signaling pathway	P01286	TGFbeta	HUMAN|HGNC=6552|UniProtKB=O75610	Left-right determination factor 1	TAS	9759503	PubMed	PTHR11848:SF181	LEFT-RIGHT DETERMINATION FACTOR 1
P00010	B cell activation	P00381	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	TAKRU|Ensembl=ENSTRUG00000002793|UniProtKB=H2S271	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF676	MYOSIN, HEAVY POLYPEPTIDE 2, FAST MUSCLE SPECIFIC
P00046	Oxidative stress response	P01132	c-jun	CHICK|Gene=JUN|UniProtKB=P18870	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	BACSU|EnsemblGenome=BSU21820|UniProtKB=P11044	Thymidylate synthase 2	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	DEIRA|EnsemblGenome=DR_0038|UniProtKB=Q9RYB2	Serine hydroxymethyltransferase	ISS			PTHR11680:SF21	SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05915	Opioid proenkephalin pathway	P05988	peptide E	PANTR|Ensembl=ENSPTRG00000020270|UniProtKB=H2QW70	Proenkephalin	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P02738	De novo purine biosynthesis	P02905	Amidophosphoribosyl transferase	DICDI|dictyBase=DDB_G0274321|UniProtKB=Q86A85	Amidophosphoribosyltransferase	ISS			PTHR11907:SF0	AMIDOPHOSPHORIBOSYLTRANSFERASE
P00049	Parkinson disease	P01221	Torsin A	MACMU|Ensembl=ENSMMUG00000016429|UniProtKB=F7GTV9	Prosalusin isoform a	ISS	12421356	PubMed	PTHR10760:SF4	TORSIN-2A
P00034	Integrin signalling pathway	P00916	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=98956|UniProtKB=P27467	Protein Wnt-3a	TAS	11266476	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02721	ATP synthesis	P02794	F1 beta	BOVIN|Ensembl=ENSBTAG00000013315|UniProtKB=P00829	ATP synthase subunit beta, mitochondrial	ISS	2896550	PubMed	PTHR15184:SF44	ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000000365|UniProtKB=F6R9F4	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00048	PI3 kinase pathway	P01198	FOXO	PANTR|Ensembl=ENSPTRG00000018476|UniProtKB=H2R710	Forkhead box O3	ISS	14775847	gi	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00012	Cadherin signaling pathway	P00470	F-actin	DANRE|ZFIN=ZDB-GENE-030131-55|UniProtKB=Q6XNL8	Actin	IC	10974003	PubMed	PTHR11937:SF263	ACTIN
P00050	Plasminogen activating cascade	P01243	uPA	HUMAN|HGNC=9052|UniProtKB=P00749	Urokinase-type plasminogen activator	ISS	137114	gi	PTHR24264:SF38	UROKINASE-TYPE PLASMINOGEN ACTIVATOR
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	ARATH|TAIR=AT4G23900|UniProtKB=Q8LAH8	Nucleoside diphosphate kinase IV, chloroplastic/mitochondrial	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	IDA	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	SCLS1|EnsemblGenome=SS1G_12343|UniProtKB=A7F345	Guanine nucleotide-binding protein alpha subunit	ISS			PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	XENTR|Xenbase=XB-GENE-480800|UniProtKB=F6VM33	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF90	FRIZZLED-8
P00057	Wnt signaling pathway	P01448	CBP	CAEEL|WormBase=WBGene00009595|UniProtKB=Q7JMS5	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000023525|UniProtKB=F7DX07	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF89	CADHERIN-5
P00006	Apoptosis signaling pathway	P00269	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BRAFL|Gene=BRAFLDRAFT_118309|UniProtKB=C3YZ17	Protein Wnt	TAS	8717036	PubMed	PTHR12027:SF100	SUBFAMILY NOT NAMED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DAPPU|EnsemblGenome=DAPPUDRAFT_228751|UniProtKB=E9HGF5	Cytoplasmatic actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DANRE|ZFIN=ZDB-GENE-040426-1354|UniProtKB=Q7T2C5	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00049	Parkinson disease	P01242	Casein kinase I	SCHPO|PomBase=SPAC23C4.12|UniProtKB=P40236	Casein kinase I homolog hhp2	IDA	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P05731	GABA-B receptor II signaling	P05752	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	HUMAN|HGNC=1394|UniProtKB=O43497	Voltage-dependent T-type calcium channel subunit alpha-1G	TAS	18021322	PubMed	PTHR10037:SF137	VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1G
P00057	Wnt signaling pathway	P01472	Histone deacetylase	CANLF|Ensembl=ENSCAFG00000004049|UniProtKB=F1PR63	Histone deacetylase	ISS	10485845	PubMed	PTHR10625:SF171	HISTONE DEACETYLASE 2
P00037	Ionotropic glutamate receptor pathway	P01001	KA4	RAT|RGD=2734|UniProtKB=Q01812	Glutamate receptor ionotropic, kainate 4	IC	12778120	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=3023|UniProtKB=P14416	D(2) dopamine receptor	IDA	11248120	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00629	PP2A	DANRE|ZFIN=ZDB-GENE-030904-6|UniProtKB=Q7ZUQ2	Ppp2r5e1 protein	ISS	11007767	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00060	Ubiquitin proteasome pathway	P01492	E1	BOVIN|Ensembl=ENSBTAG00000015556|UniProtKB=Q0P5I7	Ubiquitin-like modifier activating enzyme 3	ISS			PTHR10953:SF6	NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00127	APP	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	XENTR|Xenbase=XB-GENE-1009027|UniProtKB=Q5FV96	MGC97852 protein	ISS			PTHR24245:SF4	G-PROTEIN COUPLED RECEPTOR 45-RELATED
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	CAEEL|WormBase=WBGene00004958|UniProtKB=Q01608	Presenilin spe-4	TAS	12834808	PubMed	PTHR10202:SF17	PRESENILIN SPE-4
P00049	Parkinson disease	P01228	DAT	MOUSE|MGI=MGI=94862|UniProtKB=Q61327	Sodium-dependent dopamine transporter	TAS	92107910	PubMed	PTHR11616:SF38	SODIUM-DEPENDENT DOPAMINE TRANSPORTER
P00029	Huntington disease	P00775	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	8649368	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=12779|UniProtKB=O14905	Protein Wnt-9b	IDA	11266476	PubMed	PTHR12027:SF84	PROTEIN WNT-9B
P00034	Integrin signalling pathway	P00910	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	15210125	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00054	Toll receptor signaling pathway	P01352	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00561	STAT	CANLF|Ensembl=ENSCAFG00000015213|UniProtKB=E2RB82	Signal transducer and activator of transcription	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00018	EGF receptor signaling pathway	P00539	14-3-3	BOVIN|Ensembl=ENSBTAG00000002108|UniProtKB=Q3SZI4	14-3-3 protein theta	ISS	10407019	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00010	B cell activation	P00384	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IDA	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	HUMAN|HGNC=1625|UniProtKB=P46094	Chemokine XC receptor 1	IC			PTHR10489:SF730	CHEMOKINE XC RECEPTOR 1
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	CAEEL|WormBase=WBGene00012968|UniProtKB=Q9XXD0	Uncharacterized protein	ISS			PTHR44192:SF2	SUBFAMILY NOT NAMED
P05730	Endogenous cannabinoid signaling	P05751	Galpha	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00020	FAS signaling pathway	P00615	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00029	Huntington disease	P00775	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00057	Wnt signaling pathway	P01438	PP2A	HUMAN|HGNC=9299|UniProtKB=P67775	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00049	Parkinson disease	P01227	20S proteasome	DANRE|ZFIN=ZDB-GENE-040426-2194|UniProtKB=Q6P0I2	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF15	PROTEASOME SUBUNIT ALPHA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	IDA	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00056	VEGF signaling pathway	P01408	Akt/PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00577	PI3K	XENTR|Xenbase=XB-GENE-6067221|UniProtKB=F6Z0J4	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CHICK|Ensembl=ENSGALG00000028749|UniProtKB=Q5ZMQ2	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	EMENI|EnsemblGenome=CADANIAG00001764|UniProtKB=Q5BEY7	Adenylosuccinate synthetase	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00018	EGF receptor signaling pathway	P00539	14-3-3	PANTR|Ensembl=ENSPTRG00000008521|UniProtKB=G2HI54	14-3-3 protein epsilon	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00057	Wnt signaling pathway	P01472	Histone deacetylase	HUMAN|HGNC=4854|UniProtKB=O15379	Histone deacetylase 3	IDA	10485845	PubMed	PTHR10625:SF132	HISTONE DEACETYLASE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	ARATH|TAIR=AT5G26980|UniProtKB=O65359	Syntaxin-41	IC			PTHR19957:SF83	SYNTAXIN-16
P00034	Integrin signalling pathway	P00938	Cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P02772	Pyruvate metabolism	P03141	Citrate Synthetase	MOUSE|MGI=MGI=1919082|UniProtKB=Q80X68	Citrate synthase	TAS	2337600	PubMed	PTHR11739:SF8	CITRATE SYNTHASE, MITOCHONDRIAL
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IC	10644715	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	DANRE|ZFIN=ZDB-GENE-020503-1|UniProtKB=Q1LWJ4	Tyrosine-protein kinase receptor	ISS	11182407	gi	PTHR24416:SF498	TYROSINE-PROTEIN KINASE RECEPTOR
P00047	PDGF signaling pathway	P01168	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00012	Cadherin signaling pathway	P00470	F-actin	BOVIN|Ensembl=ENSBTAG00000014614|UniProtKB=P62739	Actin, aortic smooth muscle	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=3234|UniProtKB=P33535	Mu-type opioid receptor	IDA	12093103	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P06664	Gonadotropin-releasing hormone receptor pathway	G06685	PAC1R	MOUSE|MGI=MGI=108449|UniProtKB=P70205	Pituitary adenylate cyclase-activating polypeptide type I receptor	RCA			PTHR12011:SF228	PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE TYPE I RECEPTOR
P04393	Ras Pathway	P04558	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	IDA	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00632	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	IC	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00012	Cadherin signaling pathway	P00474	Wnt	RAT|RGD=1304988|UniProtKB=A0A0G2K6Q8	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00029	Huntington disease	G01535	PIG3	BOVIN|Ensembl=ENSBTAG00000003162|UniProtKB=O97764	Zeta-crystallin	TAS	12932731	PubMed	PTHR44154:SF1	QUINONE OXIDOREDUCTASE
P00057	Wnt signaling pathway	P01446	Calcineurin	PANTR|Ensembl=ENSPTRG00000002631|UniProtKB=H2Q237	Serine/threonine-protein phosphatase	ISS	7532676	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	BACSU|EnsemblGenome=BSU20060|UniProtKB=O31875	Ribonucleoside-diphosphate reductase NrdEB subunit alpha	ISS			PTHR11573:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT ALPHA
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	8925912	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00025	Hedgehog signaling pathway	P00682	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00059	p53 pathway	G01574	ARF	HUMAN|HGNC=1788|UniProtKB=P42772	Cyclin-dependent kinase 4 inhibitor B	RCA			PTHR24148:SF47	CYCLIN-DEPENDENT KINASE 4 INHIBITOR B-RELATED
P02769	Purine metabolism	P03119	5'-Nucleotidase	MOUSE|MGI=MGI=99782|UniProtKB=Q61503	5'-nucleotidase	NAS	3219501	gi	PTHR11575:SF25	5'-NUCLEOTIDASE
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00018	EGF receptor signaling pathway	P00539	14-3-3	PANTR|Ensembl=ENSPTRG00000011641|UniProtKB=H2QHF1	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	ISS	10407019	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00013	Cell cycle	P00480	Proteasome	MOUSE|MGI=MGI=1201670|UniProtKB=O35226	26S proteasome non-ATPase regulatory subunit 4	ISS	10505793	PubMed	PTHR10223:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4
P00056	VEGF signaling pathway	P01424	Sck	HUMAN|HGNC=29869|UniProtKB=P98077	SHC-transforming protein 2	IDA	10749680	PubMed	PTHR10337:SF5	SHC-TRANSFORMING PROTEIN 2
P05915	Opioid proenkephalin pathway	P05994	G-protein	XENTR|Xenbase=XB-GENE-6050844|UniProtKB=F6WNJ9	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00006	Apoptosis signaling pathway	P00274	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IDA	22246731	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00005	Angiogenesis	P00200	Dsh	MOUSE|MGI=MGI=94941|UniProtKB=P51141	Segment polarity protein dishevelled homolog DVL-1	ISS	7906389	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P00047	PDGF signaling pathway	P01167	Ets	HUMAN|HGNC=3488|UniProtKB=P14921	Protein C-ets-1	ISS	15298723	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00029	Huntington disease	P00790	beta-Tubulin	ORNAN|Ensembl=ENSOANG00000004061|UniProtKB=F6TYN8	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00023	General transcription regulation	P00666	TFIIE	MOUSE|MGI=MGI=1915403|UniProtKB=Q9D902	General transcription factor IIE subunit 2	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P00011	Blood coagulation	P00446	FVIIIa	MOUSE|MGI=MGI=88383|UniProtKB=Q06194	Coagulation factor VIII	ISS	6679733	gi	PTHR45309:SF1	COAGULATION FACTOR VIII
P00049	Parkinson disease	P01241	TH	MOUSE|MGI=MGI=98735|UniProtKB=P24529	Tyrosine 3-monooxygenase	TAS	12814656	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00059	p53 pathway	P04633	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01418	Paxillin	HUMAN|HGNC=11767|UniProtKB=O43294	Transforming growth factor beta-1-induced transcript 1 protein	ISS			PTHR24216:SF27	TRANSFORMING GROWTH FACTOR BETA-1-INDUCED TRANSCRIPT 1 PROTEIN
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	MOUSE|MGI=MGI=1338938|UniProtKB=P36895	Bone morphogenetic protein receptor type-1A	IDA			PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00006	Apoptosis signaling pathway	P00321	HSP70	PHYPA|Gene=PHYPADRAFT_230273|UniProtKB=A9SNF1	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00047	PDGF signaling pathway	P01154	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02757	O-antigen biosynthesis	P03047	dTDP-4-dehydrorhamnose 3,5-epimerase	BACTN|EnsemblGenome=BT_0464|UniProtKB=Q8AAK0	dTDP-4-dehydrorhamnose 3,5-epimerase	ISS			PTHR21047:SF2	DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE
P00021	FGF signaling pathway	P00623	FGF	XENTR|Xenbase=XB-GENE-481880|UniProtKB=B7UCP9	Fibroblast growth factor	ISS	10441498	PubMed	PTHR11486:SF72	FIBROBLAST GROWTH FACTOR 20
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	IDA	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IC	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	XENTR|Xenbase=XB-GENE-480396|UniProtKB=F7DI28	Protein Wnt (Fragment)	ISS	8717036	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00046	Oxidative stress response	P01131	MKP5	HUMAN|HGNC=3064|UniProtKB=P28562	Dual specificity protein phosphatase 1	TAS			PTHR10159:SF309	DUAL SPECIFICITY PROTEIN PHOSPHATASE 1
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00005	Angiogenesis	P00203	Erk	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	PSEAE|EnsemblGenome=PA5415|UniProtKB=Q9HTE9	Serine hydroxymethyltransferase 1	ISS			PTHR11680:SF19	SUBFAMILY NOT NAMED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	NEUCR|EnsemblGenome=EFNCRG00000004240|UniProtKB=Q01386	cAMP-dependent protein kinase regulatory subunit	IC	2372396	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	DANRE|ZFIN=ZDB-GENE-990415-29|UniProtKB=Q91398	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05915	Opioid proenkephalin pathway	P05992	met-Enkephalin	PANTR|Ensembl=ENSPTRG00000020270|UniProtKB=H2QW70	Proenkephalin	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00012	Cadherin signaling pathway	P00474	Wnt	PANTR|Ensembl=ENSPTRG00000009321|UniProtKB=H2QD96	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8700|UniProtKB=Q9Y5H1	Protocadherin gamma-A2	IDA	8120095	PubMed	PTHR24028:SF134	PROTOCADHERIN GAMMA-A2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IDA	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00018	EGF receptor signaling pathway	P00561	STAT	BOVIN|Gene=STAT3|UniProtKB=P61635	Signal transducer and activator of transcription 3	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00006	Apoptosis signaling pathway	P00299	Caspase 8	PANTR|Ensembl=ENSPTRG00000012801|UniProtKB=H2QJ86	Caspase 8, apoptosis-related cysteine peptidase	ISS	11917123	PubMed	PTHR10454:SF162	CASPASE-8
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CHICK|Ensembl=ENSGALG00000011086|UniProtKB=P68139	Actin, alpha skeletal muscle	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	YEAST|SGD=S000002987|UniProtKB=P43639	Casein kinase II subunit beta	IDA	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00021	FGF signaling pathway	P00629	PP2A	IXOSC|EnsemblGenome=ISCW014549|UniProtKB=B7QGY5	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00623	FGF	MACMU|Ensembl=ENSMMUG00000023509|UniProtKB=F7E243	Fibroblast growth factor	ISS	12799194	PubMed	PTHR11486:SF86	FIBROBLAST GROWTH FACTOR 1
P00019	Endothelin signaling pathway	P00590	IP3 R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00625	MKK3,6	ORNAN|Ensembl=ENSOANG00000007732|UniProtKB=F6PXH5	Uncharacterized protein (Fragment)	ISS	11971971	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00054	Toll receptor signaling pathway	P01355	AP1	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	12972619	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P02728	Arginine biosynthesis	P02846	Ornithine carbamoyl transferase	MOUSE|MGI=MGI=97448|UniProtKB=P11725	Ornithine carbamoyltransferase, mitochondrial	ISS			PTHR11405:SF1	ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	IC	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	MOUSE|MGI=MGI=97364|UniProtKB=O35516	Neurogenic locus notch homolog protein 2	IDA	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MOUSE|MGI=MGI=1928375|UniProtKB=Q9JM76	Actin-related protein 2/3 complex subunit 3	ISS	12473693	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P06664	Gonadotropin-releasing hormone receptor pathway	P06847	JNK1/2	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	RCA	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	IDA	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	XENTR|Xenbase=XB-GENE-961282|UniProtKB=Q6DF43	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00059	p53 pathway	G04699	BAI-1	HUMAN|HGNC=943|UniProtKB=O14514	Brain-specific angiogenesis inhibitor 1	IGI	9393972	PubMed	PTHR12011:SF39	BRAIN-SPECIFIC ANGIOGENESIS INHIBITOR 1
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	MACMU|Ensembl=ENSMMUG00000010173|UniProtKB=F7AGU8	Presenilin	ISS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00036	Interleukin signaling pathway	P00975	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	BOVIN|Gene=PSMD13|UniProtKB=Q5E964	26S proteasome non-ATPase regulatory subunit 13	ISS	10225435	PubMed	PTHR10539:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	TAKRU|Ensembl=ENSTRUG00000003520|UniProtKB=H2S791	Uncharacterized protein	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CANLF|Ensembl=ENSCAFG00000002380|UniProtKB=E2RHX6	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF195	BETA-CENTRACTIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	RCA	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	HUMAN|HGNC=1401|UniProtKB=Q02641	Voltage-dependent L-type calcium channel subunit beta-1	IC	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00629	PP2A	CANLF|Ensembl=ENSCAFG00000008850|UniProtKB=E2R0J6	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B	ISS	137056	PubMed	PTHR11871:SF2	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00192	PAR	PANTR|Ensembl=ENSPTRG00000015263|UniProtKB=H2QN59	Uncharacterized protein	ISS			PTHR24082:SF39	NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2
P00004	Alzheimer disease-presenilin pathway	P00118	E-cadherin	RAT|RGD=621089|UniProtKB=F1LMI3	Cadherin 3, type 1, P-cadherin (Placental)	ISS	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00047	PDGF signaling pathway	P01148	Grb2	HUMAN|HGNC=4566|UniProtKB=P62993	Growth factor receptor-bound protein 2	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00059	p53 pathway	P04630	PP2A	BOVIN|Ensembl=ENSBTAG00000000469|UniProtKB=P67774	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MOUSE|MGI=MGI=102643|UniProtKB=O08638	Myosin-11	ISS	89264452	PubMed	PTHR13140:SF335	MYOSIN-11
P04398	p53 pathway feedback loops 2	P04657	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00034	Integrin signalling pathway	P00931	Integrin beta	BOVIN|Ensembl=ENSBTAG00000009987|UniProtKB=F1MTN1	Integrin beta	ISS	3487386	PubMed	PTHR10082:SF25	INTEGRIN BETA-3
P00012	Cadherin signaling pathway	P00477	GSK3beta	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00203	Erk	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	RAT|RGD=1307277|UniProtKB=D3ZSB7	Ribosomal protein S6 kinase	ISS	9792677	PubMed	PTHR24351:SF41	RIBOSOMAL PROTEIN S6 KINASE ALPHA-4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	MACMU|Ensembl=ENSMMUG00000006132|UniProtKB=F7AZ71	Uncharacterized protein	ISS	9388255	PubMed	PTHR10639:SF1	CLATHRIN LIGHT CHAIN A
P00048	PI3 kinase pathway	P01188	Gbetagamma	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	8170357	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00048	PI3 kinase pathway	P01188	Gbetagamma	MOUSE|MGI=MGI=109165|UniProtKB=Q61012	Guanine nucleotide-binding protein G(T) subunit gamma-T1	ISS	3100519	PubMed	PTHR13809:SF26	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT GAMMA-T1
P00053	T cell activation	P01322	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00568	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00643	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MOUSE|MGI=MGI=95822|UniProtKB=Q01098	Glutamate receptor ionotropic, NMDA 2C	IC	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	BOVIN|Ensembl=ENSBTAG00000019210|UniProtKB=F1MJV4	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00054	Toll receptor signaling pathway	P01369	MKK1	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05915	Opioid proenkephalin pathway	P05993	AC	RAT|RGD=619966|UniProtKB=F1LQT1	Adenylate cyclase 7	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	DANRE|ZFIN=ZDB-GENE-990715-9|UniProtKB=B0S7D7	Uncharacterized protein	IGI	10485843	PubMed	PTHR10005:SF15	SKI ONCOGENE
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	STRCO|Gene=CAB66175|UniProtKB=Q9RDS6	Probable glutamine synthetase (EC 6.3.1.2)	ISS			PTHR43785:SF1	TYPE-1 GLUTAMINE SYNTHETASE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DANRE|ZFIN=ZDB-GENE-040426-1354|UniProtKB=Q7T2C5	Protein kinase C	ISS	11880265	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02743	Formyltetrahydroformate biosynthesis	P02952	Methylene tetrahydrofolate dehydrogenase	FUSNN|EnsemblGenome=FN1488|UniProtKB=Q8RDM4	Bifunctional protein FolD	ISS			PTHR10025:SF46	BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, MITOCHONDRIAL
P00019	Endothelin signaling pathway	P00591	PLCbeta	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00019	Endothelin signaling pathway	P00589	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00020	FAS signaling pathway	P00599	Caspase3	CANLF|Ensembl=ENSCAFG00000007750|UniProtKB=Q8MKI5	Caspase-3	IGI	11675509	PubMed	PTHR10454:SF198	CASPASE-3
P00025	Hedgehog signaling pathway	P00682	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	IDA	10477300	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00012	Cadherin signaling pathway	P00470	F-actin	LEIMA|EnsemblGenome=LmjF.04.1230|UniProtKB=Q9U1E8	Actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_116948|UniProtKB=C3YKS6	Putative uncharacterized protein	ISS			PTHR11937:SF359	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00012	Cadherin signaling pathway	P00474	Wnt	TAKRU|Ensembl=ENSTRUG00000016522|UniProtKB=H2UZ46	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00036	Interleukin signaling pathway	P00968	Ikk	MOUSE|MGI=MGI=1338071|UniProtKB=O88351	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=2136738|UniProtKB=Q91XZ6	Protein Pcdhb4	IDA	8120095	PubMed	PTHR24028:SF87	PROTEIN PCDHB4
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00034	Integrin signalling pathway	P00944	Actin	HUMAN|HGNC=144|UniProtKB=P63261	Actin, cytoplasmic 2	IPI	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P02787	Vitamin B6 metabolism	P03236	Pyridoxamine phosphate oxidase	PANTR|Ensembl=ENSPTRG00000009343|UniProtKB=H2QDB2	Pyridoxamine 5'-phosphate oxidase	ISS	9601034	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00053	T cell activation	P01322	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00049	Parkinson disease	P01235	Fyn kinase	CHICK|Gene=FYN|UniProtKB=Q05876	Tyrosine-protein kinase Fyn	IDA	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	IDA	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IC	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00049	Parkinson disease	P01212	p38 MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	ANOGA|EnsemblGenome=AGAP002972|UniProtKB=Q7QD60	AGAP002972-PA	ISS	85270494	PubMed	PTHR18945:SF430	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-LIKE 2
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04393	Ras Pathway	P04552	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	TAS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04585	TRH	HUMAN|HGNC=1885|UniProtKB=P01215	Glycoprotein hormones alpha chain	ISS			PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00303	c-Jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	IDA	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00049	Parkinson disease	P01227	20S proteasome	DANRE|ZFIN=ZDB-GENE-050522-479|UniProtKB=Q4VBR8	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF16	PROTEASOME SUBUNIT ALPHA TYPE-2
P00047	PDGF signaling pathway	P01143	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10875333	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	RAT|RGD=2025|UniProtKB=P68136	Actin, alpha skeletal muscle	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00010	B cell activation	P00391	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00976	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	MACMU|Gene=CCL18|UniProtKB=Q8HYP8	C-C motif chemokine 18	ISS	4506831	gi	PTHR12015:SF94	C-C MOTIF CHEMOKINE 18
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02765	Phenylalanine biosynthesis	P03099	Prephenate dehydratase	STRCO|Gene=CAA22234|UniProtKB=Q9ZBX0	Prephenate dehydratase	ISS			PTHR21022:SF0	PREPHENATE DEHYDRATASE-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9441|UniProtKB=P51817	cAMP-dependent protein kinase catalytic subunit PRKX	IC	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	ORNAN|Ensembl=ENSOANG00000013961|UniProtKB=F6VPY1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00054	Toll receptor signaling pathway	P01375	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	CANLF|Ensembl=ENSCAFG00000001622|UniProtKB=E2RN76	Uncharacterized protein	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P06664	Gonadotropin-releasing hormone receptor pathway	P06708	PR	MOUSE|MGI=MGI=97567|UniProtKB=Q00175	Progesterone receptor	RCA			PTHR24084:SF7	PROGESTERONE RECEPTOR
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95818|UniProtKB=Q61626	Glutamate receptor ionotropic, kainate 5	ISS	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DANRE|ZFIN=ZDB-GENE-040426-1178|UniProtKB=Q7SY24	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	G06901	BMP7	MOUSE|MGI=MGI=103302|UniProtKB=P23359	Bone morphogenetic protein 7	RCA	9759503	PubMed	PTHR11848:SF135	BONE MORPHOGENETIC PROTEIN 7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00029	Huntington disease	P00777	CBP	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02746	Heme biosynthesis	P02982	Protoheme IX farnesyl transferase	SULSO|EnsemblGenome=SSO0656|UniProtKB=Q9UX46	Protoheme IX farnesyltransferase	ISS			PTHR43448:SF2	PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL
P00047	PDGF signaling pathway	P01151	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT3G59790|UniProtKB=Q9M1Z5	Mitogen-activated protein kinase 10	ISS	9836510	gi	PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P00034	Integrin signalling pathway	P00943	Talin	MONDO|Ensembl=ENSMODG00000007430|UniProtKB=F7DWL1	Uncharacterized protein (Fragment)	ISS	14702644	PubMed	PTHR19981:SF7	MESODERM DEVELOPMENT CANDIDATE 1-RELATED
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	DICDI|dictyBase=DDB_G0281385|UniProtKB=P32253	Ras-like protein rasC	ISS	8290260	PubMed	PTHR24070:SF251	RAS-LIKE PROTEIN RASC
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	ENTHI|Gene=EHI_020610|UniProtKB=P52653	TATA-box-binding protein 1	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00005	Angiogenesis	P00236	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=88397|UniProtKB=Q9ERZ4	Muscarinic acetylcholine receptor M2	IDA	91373358	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	RAT|RGD=71009|UniProtKB=P21932	Adenylate cyclase type 3	IDA	2255909	PubMed	PTHR11920:SF291	ADENYLATE CYCLASE TYPE 3
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00010	B cell activation	P00375	Calmodulin	MONDO|Ensembl=ENSMODG00000025146|UniProtKB=F7CLC0	Uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF311	CALMODULIN
P02738	De novo purine biosynthesis	P02909	GDP reductase	PANTR|Ensembl=ENSPTRG00000020481|UniProtKB=H2QWI9	Ribonucleotide reductase M2 B (TP53 inducible)	ISS			PTHR23409:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 B
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	RAT|RGD=61863|UniProtKB=P19493	Glutamate receptor 4	ISS	12871085	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P05731	GABA-B receptor II signaling	P05755	Gbeta	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	HUMAN|HGNC=4584|UniProtKB=Q05586	Glutamate receptor ionotropic, NMDA 1	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P02734	Chorismate biosynthesis	P02869	3-Dehydroquinate dehydratase	NEUCR|EnsemblGenome=EFNCRG00000005408|UniProtKB=P05195	Catabolic 3-dehydroquinase	ISS			PTHR21272:SF4	SUBFAMILY NOT NAMED
P00010	B cell activation	P00379	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00056	VEGF signaling pathway	P01407	Erk	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02754	Methylcitrate cycle	P03028	Aconitase	DEIRA|EnsemblGenome=DR_1720|UniProtKB=Q9RTN7	Aconitate hydratase A	ISS			PTHR11670:SF1	ACONITATE HYDRATASE
P00019	Endothelin signaling pathway	P00591	PLCbeta	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00057	Wnt signaling pathway	P01451	Galpha	BOVIN|Ensembl=ENSBTAG00000019988|UniProtKB=F1N2V3	Uncharacterized protein	ISS	11534853	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DROME|FlyBase=FBgn0004623|UniProtKB=P29829	Guanine nucleotide-binding protein subunit beta-2	IC	11313908	PubMed	PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	MOUSE|MGI=MGI=99659|UniProtKB=E9PZQ0	Ryanodine receptor 1	ISS	15226293	PubMed	PTHR13715:SF15	RYANODINE RECEPTOR 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00568	PKC	DANRE|ZFIN=ZDB-GENE-040426-1354|UniProtKB=Q7T2C5	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00245	Rac	MACMU|Ensembl=ENSMMUG00000031000|UniProtKB=F6Y6A5	Uncharacterized protein	ISS			PTHR23176:SF3	PROTEIN PRR5-ARHGAP8-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	RAT|RGD=2735|UniProtKB=Q63273	Glutamate receptor ionotropic, kainate 5	ISS	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ORNAN|Ensembl=ENSOANG00000007581|UniProtKB=F6QWB7	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00055	Transcription regulation by bZIP transcription factor	P01391	TFIIFalpha	XENTR|Xenbase=XB-GENE-974834|UniProtKB=B1H3B7	LOC100124929 protein	ISS			PTHR13011:SF0	GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1
P00004	Alzheimer disease-presenilin pathway	P00127	APP	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	SCHPO|PomBase=SPBC106.10|UniProtKB=P40376	cAMP-dependent protein kinase catalytic subunit	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02743	Formyltetrahydroformate biosynthesis	P02958	Dihydrofolate synthase	FUSNN|EnsemblGenome=FN1014|UniProtKB=Q8RES8	Folylpolyglutamate synthase	ISS			PTHR11136:SF0	DIHYDROFOLATE SYNTHETASE-RELATED
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01312	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	CHICK|Ensembl=ENSGALG00000008058|UniProtKB=F1N8W8	Uncharacterized protein	ISS	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	MACMU|Ensembl=ENSMMUG00000017022|UniProtKB=F7HQZ9	Uncharacterized protein	ISS	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00018	EGF receptor signaling pathway	P00545	JNK1-3	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04375	5HT3 type receptor mediated signaling pathway	P04421	5HT transporter	PANTR|Ensembl=ENSPTRG00000008958|UniProtKB=H2QCL1	Transporter	ISS	14653308	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IC	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04398	p53 pathway feedback loops 2	P04661	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04566	Stat 1/3	MONDO|Ensembl=ENSMODG00000028212|UniProtKB=F7BYN4	Signal transducer and activator of transcription	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	90172230	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	IDA	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00021	FGF signaling pathway	P00648	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=19218|UniProtKB=Q86YW0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1	ISS	12860966	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=2444559|UniProtKB=Q6P5G0	Mitogen-activated protein kinase 4	ISS	10514528	PubMed	PTHR24055:SF25	MITOGEN-ACTIVATED PROTEIN KINASE 4
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Ensembl=ENSPTRG00000017441|UniProtKB=H2QRU7	Glutamate receptor, ionotropic, AMPA 1	ISS	10331083	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01132	c-jun	CHICK|Gene=JUN|UniProtKB=P18870	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02756	N-acetylglucosamine metabolism	P03041	Glucosamine-6-phosphate deaminase	CANLF|Ensembl=ENSCAFG00000001871|UniProtKB=E2RH59	Glucosamine-6-phosphate isomerase	ISS			PTHR11280:SF9	GLUCOSAMINE-6-PHOSPHATE ISOMERASE 2
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	MACMU|Ensembl=ENSMMUG00000017431|UniProtKB=F7HPP3	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00034	Integrin signalling pathway	P00927	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12874273	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=12784|UniProtKB=P41221	Protein Wnt-5a	IDA	8717036	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00029	Huntington disease	P00801	Fos protein	MONDO|Ensembl=ENSMODG00000005927|UniProtKB=F6WX28	Uncharacterized protein	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P02738	De novo purine biosynthesis	P02891	GDP kinase	SYNY3|EnsemblGenome=BAA18596|UniProtKB=P74494	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P04393	Ras Pathway	P04558	p38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IDA	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00006	Apoptosis signaling pathway	P00318	PKCs	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00899	IRS 1-4	MACMU|Ensembl=ENSMMUG00000019467|UniProtKB=F6SUL3	Uncharacterized protein	ISS	1311924	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00047	PDGF signaling pathway	P01154	Ras	DICPU|Gene=DICPUDRAFT_51488|UniProtKB=F1A411	Putative uncharacterized protein rasC	ISS	8290260	PubMed	PTHR24070:SF251	RAS-LIKE PROTEIN RASC
P00019	Endothelin signaling pathway	P00586	Gq	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01453	Ebi	MOUSE|MGI=MGI=2441730|UniProtKB=Q8BHJ5	F-box-like/WD repeat-containing protein TBL1XR1	IDA	11389839	PubMed	PTHR22846:SF40	F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN TBL1XR1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	MACMU|Ensembl=ENSMMUG00000017101|UniProtKB=F7H5B5	CTP synthase	ISS			PTHR11550:SF8	CTP SYNTHASE 1
P00010	B cell activation	P00367	NFAT	MACMU|Ensembl=ENSMMUG00000021843|UniProtKB=F6RNI3	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00057	Wnt signaling pathway	P01444	Wnt	BRAFL|Gene=BRAFLDRAFT_118160|UniProtKB=C3Z2P0	Protein Wnt	IDA	11266476	PubMed	PTHR12027:SF77	PROTEIN WNT-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	BOVIN|Ensembl=ENSBTAG00000034883|UniProtKB=A6QLA5	CCR4 protein	ISS	11698495	PubMed	PTHR10489:SF608	C-C CHEMOKINE RECEPTOR TYPE 4
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	HUMAN|HGNC=7567|UniProtKB=P12882	Myosin-1	IEP	10938134	PubMed	PTHR13140:SF484	MYOSIN-1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P02738	De novo purine biosynthesis	P02904	Guanylate kinase	ARATH|TAIR=AT3G06200|UniProtKB=Q94JM2	Guanylate kinase 3, chloroplastic	ISS			PTHR23117:SF12	GUANYLATE KINASE 3, CHLOROPLASTIC
P00056	VEGF signaling pathway	P01413	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04417	5HT transporter	MACMU|Gene=SLC6A4|UniProtKB=Q9MYX0	Sodium-dependent serotonin transporter	ISS	14653308	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P05730	Endogenous cannabinoid signaling	P05746	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	1504106	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00114	actin	YEAST|SGD=S000001855|UniProtKB=P60010	Actin	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00029	Huntington disease	P00811	Arp2/3 complex	MACMU|Ensembl=ENSMMUG00000001458|UniProtKB=F7BKH1	Uncharacterized protein	ISS	12473693	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00034	Integrin signalling pathway	P00933	Crk	RAT|RGD=2405|UniProtKB=Q63768	Adapter molecule crk	ISS	8649368	PubMed	PTHR19969:SF8	ADAPTER MOLECULE CRK
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	MONDO|Ensembl=ENSMODG00000023174|UniProtKB=F7D7P2	Uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF197	CALMODULIN-LIKE PROTEIN 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	10218114	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00629	PP2A	TAKRU|Ensembl=ENSTRUG00000014207|UniProtKB=H2UHB2	Uncharacterized protein	ISS			PTHR10648:SF4	PROTEIN PHOSPHATASE 2  FORMERLY 2A , REGULATORY SUBUNIT A, BETA ISOFORM
P00005	Angiogenesis	P00211	GSK3beta	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	DROME|FlyBase=FBgn0001991|UniProtKB=Q24270	Voltage-dependent calcium channel type D subunit alpha-1	IC	10514528	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	RAT|RGD=2732|UniProtKB=P22756	Glutamate receptor ionotropic, kainate 1	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	CHICK|Ensembl=ENSGALG00000003003|UniProtKB=Q8QG55	C-C motif chemokine	IDA	12067311	PubMed	PTHR12015:SF108	C-C MOTIF CHEMOKINE 20
P00029	Huntington disease	P00787	MAPKK4	CHICK|Ensembl=ENSGALG00000001001|UniProtKB=F1P3T1	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P02750	Lipoate_biosynthesis	P03004	Lipoate synthase	MACMU|Ensembl=ENSMMUG00000013851|UniProtKB=F6RMC6	Lipoyl synthase, mitochondrial	ISS			PTHR10949:SF0	LIPOYL SYNTHASE, MITOCHONDRIAL
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MONDO|Ensembl=ENSMODG00000018204|UniProtKB=F6PGX6	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00046	Oxidative stress response	P01136	Elk-1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	TAS	14670631	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	CANLF|Ensembl=ENSCAFG00000012608|UniProtKB=E2RCP9	Uncharacterized protein	ISS			PTHR10943:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	RAT|RGD=2060|UniProtKB=P10608	Beta-2 adrenergic receptor	IDA	12063255	PubMed	PTHR24248:SF21	BETA-2 ADRENERGIC RECEPTOR
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00897	SHIP2	PANTR|Ensembl=ENSPTRG00000004031|UniProtKB=H2Q4C6	Inositol polyphosphate phosphatase-like 1	ISS	9824312	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00048	PI3 kinase pathway	P01199	Galpha	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	RAT|RGD=621705|UniProtKB=Q8VHN2	Glutamate receptor ionotropic, NMDA 3B	IC	11319238	PubMed	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P02723	Adenine and hypoxanthine salvage pathway	P02807	Deoxyadenosine deaminase	STRCO|EnsemblGenome=CAB77418|UniProtKB=Q9L0L6	Putative adenosine/adenine deaminase	ISS			PTHR43114:SF3	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00572	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00005	Angiogenesis	P00218	STAT1	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02757	O-antigen biosynthesis	P03047	dTDP-4-dehydrorhamnose 3,5-epimerase	METAC|EnsemblGenome=MA_3780|UniProtKB=Q8TJK4	dTDP-4-dehydrorhamnose 3,5-epimerase	ISS			PTHR21047:SF2	DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	CHICK|Gene=BMPR1B|UniProtKB=Q05438	Bone morphogenetic protein receptor type-1B	TAS	9395284	PubMed	PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P02738	De novo purine biosynthesis	P02909	GDP reductase	XENTR|Xenbase=XB-GENE-1014077|UniProtKB=F6TKJ2	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P05731	GABA-B receptor II signaling	P05754	Ggamma	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05923	beta-ARR2	RAT|RGD=2157|UniProtKB=P29067	Beta-arrestin-2	RCA	12464600	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00049	Parkinson disease	P01208	Hsp70	MACMU|Ensembl=ENSMMUG00000029822|UniProtKB=F7CZ86	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF210	HEAT SHOCK 70 KDA PROTEIN 1-LIKE
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	ORNAN|Ensembl=ENSOANG00000010302|UniProtKB=F6TDQ6	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	RCA	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	RAT|RGD=71014|UniProtKB=Q04400	Adenylate cyclase type 5	IDA	1409703	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	PANTR|Gene=CHRNB3|UniProtKB=Q5IS75	Neuronal acetylcholine receptor subunit beta-3	ISS	15155845	PubMed	PTHR18945:SF75	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	TAS	15531926	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	RAT|RGD=2157|UniProtKB=P29067	Beta-arrestin-2	IDA	4757780	gi	PTHR11792:SF20	BETA-ARRESTIN-2
P00049	Parkinson disease	P01235	Fyn kinase	BOVIN|Ensembl=ENSBTAG00000011851|UniProtKB=A0JNB0	Tyrosine-protein kinase Fyn	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00539	14-3-3	MONDO|Ensembl=ENSMODG00000006158|UniProtKB=F7BS95	Uncharacterized protein	ISS	92283271	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00047	PDGF signaling pathway	P01171	PLCgamma	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00013	Cell cycle	P00485	Cdk2	RAT|RGD=1563395|UniProtKB=B0BNM8	Cyclin-dependent kinase 2-interacting protein	ISS	12477932	PubMed	PTHR15827:SF2	CYCLIN-DEPENDENT KINASE 2-INTERACTING PROTEIN
P00021	FGF signaling pathway	P00628	JNK1-3	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00019	Endothelin signaling pathway	P00566	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01307	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00018	EGF receptor signaling pathway	P00543	ERK1-2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000008186|UniProtKB=H2QB90	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF273	CADHERIN-8
P00019	Endothelin signaling pathway	P00577	PI3K	CANAL|CGD=CAL0068551|UniProtKB=Q5AAR9	Phosphatidylinositol 3-kinase	IGI	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	ARATH|TAIR=AT4G11010|UniProtKB=O49203	Nucleoside diphosphate kinase III, chloroplastic/mitochondrial	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00005	Angiogenesis	P00224	PDGF	PANTR|Ensembl=ENSPTRG00000016546|UniProtKB=H2QQC3	Platelet derived growth factor C	ISS			PTHR11633:SF5	PLATELET-DERIVED GROWTH FACTOR C
P00029	Huntington disease	P00807	Actin	ORYSJ|EnsemblGenome=OS12G0163700|UniProtKB=Q0IPW3	Os12g0163700 protein	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04393	Ras Pathway	P04558	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	IDA	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00586	Gq	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	IDA	20032362	PubMed	PTHR24055:SF330	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01440	Cadherin	ORNAN|Ensembl=ENSOANG00000002498|UniProtKB=F6VFP8	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF106	CADHERIN-18
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00023	General transcription regulation	P00666	TFIIE	HUMAN|HGNC=4650|UniProtKB=P29083	General transcription factor IIE subunit 1	ISS	92065982	PubMed	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	RAT|RGD=67366|UniProtKB=P50393	Cytosolic phospholipase A2	IEA	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00029	Huntington disease	P00775	Rac	ARATH|TAIR=AT4G28950|UniProtKB=O82480	Rac-like GTP-binding protein ARAC7	TAS			PTHR24072:SF127	RAC-LIKE GTP-BINDING PROTEIN ARAC7
P05915	Opioid proenkephalin pathway	P05994	G-protein	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	METAC|EnsemblGenome=MA_0179|UniProtKB=Q8TU94	TATA-box-binding protein 2	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00048	PI3 kinase pathway	P01199	Galpha	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS			PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MOUSE|MGI=MGI=96648|UniProtKB=P15066	Transcription factor jun-D	TAS	10664585	PubMed	PTHR11462:SF7	TRANSCRIPTION FACTOR JUN-D
P05731	GABA-B receptor II signaling	P05754	Ggamma	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04398	p53 pathway feedback loops 2	P04661	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00589	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00011	Blood coagulation	P00406	Fibrinogen	PANTR|Ensembl=ENSPTRG00000016534|UniProtKB=H2QQB4	Uncharacterized protein	ISS	223002	gi	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CANLF|Ensembl=ENSCAFG00000008756|UniProtKB=F2Z4N8	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P02728	Arginine biosynthesis	P02847	N-actetylornithine deacetylase	BACSU|EnsemblGenome=BSU19710|UniProtKB=O34984	Uncharacterized metallohydrolase YodQ	ISS			PTHR43325:SF1	SUBFAMILY NOT NAMED
P00010	B cell activation	P00381	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04397	p53 pathway by glucose deprivation	P04639	AMPK	MOUSE|MGI=MGI=1336185|UniProtKB=Q6PAM0	5'-AMP-activated protein kinase subunit beta-2	ISS			PTHR10343:SF45	5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2
P02770	Pyridoxal phosphate salvage pathway	P03121	Pyridoxal kinase	CAEEL|WormBase=WBGene00019008|UniProtKB=O01824	Putative pyridoxal kinase	ISS			PTHR10534:SF2	PYRIDOXAL KINASE
P00053	T cell activation	P01305	Calmodulin	ARATH|TAIR=AT3G43810|UniProtKB=P59220	Calmodulin-7	ISS	9753452	PubMed	PTHR23050:SF250	CALMODULIN-7
P00005	Angiogenesis	P00238	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00036	Interleukin signaling pathway	P00962	ELK	RAT|RGD=1307764|UniProtKB=D4A9V6	ELK3, member of ETS oncogene family (Predicted), isoform CRA_a	ISS			PTHR11849:SF172	ETS DOMAIN-CONTAINING PROTEIN ELK-3
P00006	Apoptosis signaling pathway	P00269	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	20027584	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DICDI|dictyBase=DDB_G0289811|UniProtKB=Q54GX7	Actin-10	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02738	De novo purine biosynthesis	P02889	dGDP kinase	MOUSE|MGI=MGI=97356|UniProtKB=Q01768	Nucleoside diphosphate kinase B	ISS			PTHR11349:SF57	NUCLEOSIDE DIPHOSPHATE KINASE B
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	CAEBR|Gene=CBG06092|UniProtKB=A8X0X5	Protein CBR-LET-60	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000014334|UniProtKB=F7CYY6	Uncharacterized protein	ISS	2039532	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00005	Angiogenesis	P00256	PLC-gamma	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8675|UniProtKB=Q9Y5H5	Protocadherin alpha-9	IDA	8120095	PubMed	PTHR24028:SF133	PROTOCADHERIN ALPHA-9
P00046	Oxidative stress response	P01129	JNK1/2	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00887	IRS 1-4	CANLF|Ensembl=ENSCAFG00000010397|UniProtKB=E2RDB5	Uncharacterized protein	ISS	5031805	gi	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00049	Parkinson disease	P01242	Casein kinase I	DROME|FlyBase=FBgn0030384|UniProtKB=Q9VYN5	AT26486p	IDA	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02728	Arginine biosynthesis	P02840	Argininosuccinate synthase	MACMU|Ensembl=ENSMMUG00000001522|UniProtKB=F7GCK5	Uncharacterized protein	ISS			PTHR11587:SF2	ARGININOSUCCINATE SYNTHASE
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	IDA	8838325	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00018	EGF receptor signaling pathway	P00548	RKIP	MOUSE|MGI=MGI=1920773|UniProtKB=Q9D9G2	Phosphatidylethanolamine-binding protein 4	ISS			PTHR11362:SF70	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	HUMAN|HGNC=174|UniProtKB=Q13705	Activin receptor type-2B	TAS	9395284	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P00052	TGF-beta signaling pathway	P01286	TGFbeta	PANTR|Ensembl=ENSPTRG00000013238|UniProtKB=H2QJY1	Bone morphogenetic protein 2	ISS	9759503	PubMed	PTHR11848:SF143	BONE MORPHOGENETIC PROTEIN 2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=19663|UniProtKB=Q9UBI6	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00053	T cell activation	P01331	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00005	Angiogenesis	P00254	GTPase	XENTR|Xenbase=XB-GENE-478301|UniProtKB=Q6NVL3	Ras homolog gene family, member B	ISS	11973360	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008026|UniProtKB=H2QAZ2	Syntaxin 1B	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00048	PI3 kinase pathway	P01182	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P05912	Dopamine receptor mediated signaling pathway	P05961	DOPA decarb.	ORYSJ|EnsemblGenome=OS10G0380800|UniProtKB=Q7G6M2	Os10g0380800 protein	ISS			PTHR11999:SF141	SUBFAMILY NOT NAMED
P00054	Toll receptor signaling pathway	P01355	AP1	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00018	EGF receptor signaling pathway	P00552	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00872	Rac	MACMU|Ensembl=ENSMMUG00000021075|UniProtKB=F7GY91	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04396	Vitamin D metabolism and pathway	P04603	1alpha-Hydroxylase	HUMAN|HGNC=2606|UniProtKB=O15528	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	IDA	11013342	PubMed	PTHR24291:SF3	25-HYDROXYVITAMIN D-1 ALPHA HYDROXYLASE, MITOCHONDRIAL
P00052	TGF-beta signaling pathway	P01286	TGFbeta	CHICK|Gene=TLL1|UniProtKB=Q9DER7	Tolloid-like protein 1	TAS	9759503	PubMed	PTHR43978:SF4	TOLLOID-LIKE PROTEIN 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=2384950|UniProtKB=Q8VCE9	Pleckstrin homology domain-containing family H member 3	IC			PTHR22903:SF17	PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY H MEMBER 3
P05913	Enkephalin release	P05977	G-Protein (s)	SCHPO|PomBase=SPBC32H8.07|UniProtKB=Q10282	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P06216	SCW signaling pathway	P06328	NEJ	DROME|FlyBase=FBgn0261617|UniProtKB=M9MS40	Nejire, isoform C	IGI	10075933	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00029	Huntington disease	P00796	Kainate receptor	RAT|RGD=2735|UniProtKB=Q63273	Glutamate receptor ionotropic, kainate 5	IDA	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P06959	CCKR signaling map	P07020	p110	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	RCA	15530849	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g234494|UniProtKB=A7RU31	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04494	TSC2	TAKRU|Ensembl=ENSTRUG00000008958|UniProtKB=H2TCY4	Uncharacterized protein	ISS	12150915	PubMed	PTHR10063:SF0	TUBERIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IDA	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	IC	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	XENTR|Xenbase=XB-GENE-963560|UniProtKB=Q0VFC4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00046	Oxidative stress response	P01132	c-jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00010	B cell activation	P00383	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02726	Aminobutyrate degradation	P02825	4-aminobutyrate aminotransferase	CAEEL|WormBase=WBGene00001794|UniProtKB=Q21217	Probable 4-aminobutyrate aminotransferase, mitochondrial	ISS	137150	OMIM	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00057	Wnt signaling pathway	P01428	Frizzled	DROME|FlyBase=FBgn0001085|UniProtKB=P18537	Frizzled	IDA	11212302	PubMed	PTHR11309:SF47	FRIZZLED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	8170357	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00018	EGF receptor signaling pathway	P00557	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	XENTR|GeneID=394982|UniProtKB=P20399	Actin, alpha cardiac muscle 2	ISS	11889139	PubMed	PTHR11937:SF263	ACTIN
P00004	Alzheimer disease-presenilin pathway	P00145	CD44	RAT|RGD=2307|UniProtKB=P26051	CD44 antigen	IDA	14871815	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_79607|UniProtKB=C3ZHN4	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P05730	Endogenous cannabinoid signaling	P05748	mGluR	RAT|RGD=2742|UniProtKB=P23385	Metabotropic glutamate receptor 1	ISS	12488551	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00029	Huntington disease	P00774	Dynein complex	RAT|RGD=2512|UniProtKB=Q63100	Cytoplasmic dynein 1 intermediate chain 1	IPI	9454836	PubMed	PTHR12442:SF34	CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN 1
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	PANTR|Ensembl=ENSPTRG00000013336|UniProtKB=H2QK41	Acetyl-coenzyme A synthetase	ISS			PTHR24095:SF110	ACETYL-COENZYME A SYNTHETASE 2-LIKE, MITOCHONDRIAL
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00006	Apoptosis signaling pathway	P00269	MAPK	ORYSJ|EnsemblGenome=OS03G0285800|UniProtKB=Q10N20	Mitogen-activated protein kinase 5	ISS	95284341	PubMed	PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00013	Cell cycle	P00489	CdkC	HUMAN|HGNC=1590|UniProtKB=O96020	G1/S-specific cyclin-E2	RCA			PTHR10177:SF70	G1/S-SPECIFIC CYCLIN-E2
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000013693|UniProtKB=H2QKP9	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF81	CADHERIN-4
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02762	Pentose phosphate pathway	P03081	Transaldolase	RAT|RGD=620674|UniProtKB=Q9EQS0	Transaldolase	ISS	8300619	PubMed	PTHR10683:SF18	TRANSALDOLASE
P00004	Alzheimer disease-presenilin pathway	P00178	BACE-1 pro-domain	MACMU|Ensembl=ENSMMUG00000007785|UniProtKB=F7CQI1	Beta-secretase 1 isoform A preproprotein	ISS	10956649	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00036	Interleukin signaling pathway	P00965	ERK	CHICK|Ensembl=ENSGALG00000004690|UniProtKB=Q5F3W3	Mitogen-activated protein kinase 6	ISS	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IC	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00046	Oxidative stress response	P01129	JNK1/2	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00005	Angiogenesis	P00243	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00940	Src	MACMU|Ensembl=ENSMMUG00000020131|UniProtKB=F7FWN4	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	CHICK|Gene=COL12A1|UniProtKB=P13944	Collagen alpha-1(XII) chain	IC	10778855	PubMed	PTHR45047:SF2	COLLAGEN ALPHA-1 XII  CHAIN
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P02752	Mannose metabolism	P03018	Mannose 1-P guanylyl transferase	ARATH|TAIR=AT3G55590|UniProtKB=Q9M2S0	Probable mannose-1-phosphate guanylyltransferase 2	TAS	15233308	gi	PTHR22572:SF136	MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE 1-RELATED
P05915	Opioid proenkephalin pathway	P05995	proenkephalin	HUMAN|HGNC=8831|UniProtKB=P01210	Proenkephalin-A	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	TAS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00984	MEK	XENTR|Xenbase=XB-GENE-481530|UniProtKB=F6U298	Uncharacterized protein	ISS			PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	DROME|FlyBase=FBgn0264695|UniProtKB=P05661	Myosin heavy chain, muscle	IC			PTHR13140:SF555	MYOSIN HEAVY CHAIN, MUSCLE
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=1767|UniProtKB=P55286	Cadherin-8	IDA	8120095	PubMed	PTHR24027:SF273	CADHERIN-8
P02747	Histidine biosynthesis	P02984	Imidazol glycerol phosphate dehydratase	ARATH|TAIR=AT4G14910|UniProtKB=O23346	Imidazoleglycerol-phosphate dehydratase 2, chloroplastic	ISS			PTHR23133:SF4	IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE 2, CHLOROPLASTIC
P00056	VEGF signaling pathway	P01419	Ets	MOUSE|MGI=MGI=95455|UniProtKB=P27577	Protein C-ets-1	ISS	3060801	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	BOVIN|Ensembl=ENSBTAG00000009269|UniProtKB=F1MCM2	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P05913	Enkephalin release	P05972	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00047	PDGF signaling pathway	P01174	Rho	PANTR|Ensembl=ENSPTRG00000001909|UniProtKB=H2R866	Uncharacterized protein	ISS			PTHR14166:SF6	SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 2-RELATED
P00018	EGF receptor signaling pathway	P00547	PP2A	ANOGA|EnsemblGenome=AGAP010172|UniProtKB=Q7PD38	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P02772	Pyruvate metabolism	P03132	Pyruvate Kinase	CAEEL|WormBase=WBGene00014001|UniProtKB=Q23539	Pyruvate kinase	TAS	17544584	gi	PTHR11817:SF27	PYRUVATE KINASE
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	IPI	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00006	Apoptosis signaling pathway	P00269	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00181	SHP2	TAKRU|Ensembl=ENSTRUG00000018529|UniProtKB=H2VDZ2	Tyrosine-protein phosphatase non-receptor type	ISS	14525967	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00057	Wnt signaling pathway	P01461	FrzB	RAT|RGD=1311315|UniProtKB=B2GUW1	Frizzled-related protein	ISS	9118218	PubMed	PTHR11309:SF97	SECRETED FRIZZLED-RELATED PROTEIN 3
P00059	p53 pathway	G01575	GADD45	BOVIN|Ensembl=ENSBTAG00000025462|UniProtKB=Q5E9A5	Growth arrest and DNA damage-inducible protein GADD45 beta	ISS	10097101	PubMed	PTHR10411:SF5	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 BETA
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	BOVIN|Ensembl=ENSBTAG00000018989|UniProtKB=A5D7D8	GRM3 protein	ISS	12351712	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00047	PDGF signaling pathway	P01143	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	1170702	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=12787|UniProtKB=P56706	Protein Wnt-7b	IDA	11266476	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P05918	p38 MAPK pathway	P06031	p38alpha	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	TAS	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P05913	Enkephalin release	P05974	G-Protein (i)	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	10704417	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	TAS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	RAT|RGD=2736|UniProtKB=P35439	Glutamate receptor ionotropic, NMDA 1	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P05913	Enkephalin release	G06046	preproenkephalin mRNA	XENTR|Xenbase=XB-GENE-942760|UniProtKB=F6Y5F6	Uncharacterized protein	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	IC	12488551	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	CAEEL|WormBase=WBGene00000295|UniProtKB=Q9GNP0	Uncharacterized protein	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P05916	Opioid prodynorphin pathway	P06002	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	HUMAN|HGNC=16767|UniProtKB=Q8TCU5	Glutamate receptor ionotropic, NMDA 3A	IC	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00034	Integrin signalling pathway	P00907	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00006	Apoptosis signaling pathway	P00274	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	TAKRU|Ensembl=ENSTRUG00000016101|UniProtKB=H2UW32	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P02775	Salvage pyrimidine ribonucleotides	P03151	Uracil phosphoribosyl  transferase	HALSA|EnsemblGenome=VNG_2305C|UniProtKB=Q9HN05	Uracil phosphoribosyltransferase	ISS			PTHR10285:SF46	URACIL PHOSPHORIBOSYLTRANSFERASE, CHLOROPLASTIC
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00005	Angiogenesis	P00238	Ras	DANRE|ZFIN=ZDB-GENE-040808-67|UniProtKB=Q6AZA4	K-ras	ISS	20362513	PubMed	PTHR24070:SF186	GTPASE KRAS
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00775	Rac	MACMU|Ensembl=ENSMMUG00000021075|UniProtKB=F7GY91	Uncharacterized protein	ISS	11756405	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000005623|UniProtKB=F7CFG8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CHICK|Ensembl=ENSGALG00000014235|UniProtKB=Q3L254	Protein Wnt-7b	ISS	11266476	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	HUMAN|HGNC=17780|UniProtKB=Q562R1	Beta-actin-like protein 2	IC	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000017335|UniProtKB=Q5DRC8	Protocadherin beta-6	ISS	8120095	PubMed	PTHR24028:SF104	PROTOCADHERIN BETA-6
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00006	Apoptosis signaling pathway	P00274	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00029	Huntington disease	P00790	beta-Tubulin	BATDJ|Gene=BATDEDRAFT_37213|UniProtKB=F4P7H8	Alpha-Beta tubulin	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-040718-93|UniProtKB=Q6DGZ5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00020	FAS signaling pathway	P00615	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00254	GTPase	PANTR|Ensembl=ENSPTRG00000014922|UniProtKB=H2QML4	Uncharacterized protein	ISS	12039949	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00036	Interleukin signaling pathway	P00995	c-Myc	CHICK|Ensembl=ENSGALG00000016308|UniProtKB=P01109	Myc proto-oncogene protein	ISS	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	PANTR|Ensembl=ENSPTRG00000011042|UniProtKB=H2QGF5	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05731	GABA-B receptor II signaling	P05754	Ggamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00049	Parkinson disease	P01230	Src kinase	TAKRU|Ensembl=ENSTRUG00000014739|UniProtKB=H2UL58	Tyrosine-protein kinase	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00034	Integrin signalling pathway	P00920	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00012	Cadherin signaling pathway	P00476	Yes	BOVIN|Ensembl=ENSBTAG00000020034|UniProtKB=F1N261	Tyrosine-protein kinase	ISS			PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P00060	Ubiquitin proteasome pathway	P01491	E2	MACMU|Ensembl=ENSMMUG00000032326|UniProtKB=F7GIS4	Uncharacterized protein	ISS			PTHR43902:SF2	UBIQUITIN-CONJUGATING ENZYME E2 N
P00048	PI3 kinase pathway	P01199	Galpha	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00021	FGF signaling pathway	P00641	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00020	FAS signaling pathway	P00615	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	MOUSE|MGI=MGI=2149593|UniProtKB=Q9WVB3	Transducin-like enhancer protein 6	IDA	9783586	PubMed	PTHR10814:SF2	TRANSDUCIN-LIKE ENHANCER PROTEIN 6
P04393	Ras Pathway	P04570	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P04393	Ras Pathway	P04572	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00639	Shc	CANLF|Ensembl=ENSCAFG00000002201|UniProtKB=F1PPW0	Uncharacterized protein	ISS	96330343	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05917	Opioid proopiomelanocortin pathway	P06008	ACTH	BOVIN|Ensembl=ENSBTAG00000007897|UniProtKB=P01190	Pro-opiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00018	EGF receptor signaling pathway	P00542	EGFR	MOUSE|MGI=MGI=95411|UniProtKB=Q61526	Receptor tyrosine-protein kinase erbB-3	ISS	17432904	gi	PTHR24416:SF88	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3
P00051	TCA cycle	P01269	alphaketoglutarate Dehydrogenase	MONDO|Ensembl=ENSMODG00000016121|UniProtKB=F7DSQ0	Uncharacterized protein (Fragment)	ISS	12477932	PubMed	PTHR23152:SF7	2-OXOGLUTARATE DEHYDROGENASE, MITOCHONDRIAL
P00057	Wnt signaling pathway	P01465	Ggamma	HUMAN|HGNC=4404|UniProtKB=P59768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IDA	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00012	Cadherin signaling pathway	P00470	F-actin	XENTR|Xenbase=XB-GENE-490883|UniProtKB=Q6NVA9	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00018	EGF receptor signaling pathway	P00539	14-3-3	MONDO|Ensembl=ENSMODG00000006158|UniProtKB=F7BS95	Uncharacterized protein	ISS	12615066	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IGI	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00022	General transcription by RNA polymerase I	P00657	TBP	TETTS|EnsemblGenome=TTHERM_00575350|UniProtKB=Q22V65	TATA box-binding protein (TBP): present in archaea and protein	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00047	PDGF signaling pathway	P01161	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01435	SWI/SNF	BOVIN|Ensembl=ENSBTAG00000014697|UniProtKB=F1N4N6	Uncharacterized protein	ISS	11532957	PubMed	PTHR12802:SF38	SWI/SNF COMPLEX SUBUNIT SMARCC2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IC	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00010	B cell activation	P00375	Calmodulin	BRAFL|Gene=BRAFLDRAFT_124869|UniProtKB=C3ZEW0	Putative uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF263	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CHICK|Ensembl=ENSGALG00000008512|UniProtKB=F1P0S6	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P04393	Ras Pathway	P04570	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00057	Wnt signaling pathway	P01443	Phospholipase C	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IDA	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	MACMU|Ensembl=ENSMMUG00000004718|UniProtKB=F6RC44	Phosphorylase b kinase regulatory subunit beta	ISS	10487978	PubMed	PTHR10749:SF8	PHOSPHORYLASE B KINASE REGULATORY SUBUNIT BETA
P00025	Hedgehog signaling pathway	P00689	Patched	RAT|RGD=621425|UniProtKB=Q6UY90	Patched	ISS	8647801	PubMed	PTHR10796:SF61	PROTEIN PATCHED HOMOLOG 1
P00006	Apoptosis signaling pathway	P00302	ATF	PANTR|Ensembl=ENSPTRG00000012660|UniProtKB=H2QJ07	Activating transcription factor 2	ISS	10664585	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00034	Integrin signalling pathway	P00927	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	15470041	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	SCHMA|EnsemblGenome=Smp_165490|UniProtKB=C1LZY9	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00920	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P02779	Thiamin biosynthesis	P03170	Hydroxymethylpyrimidine phosphate kinase	AQUAE|EnsemblGenome=aq_1960|UniProtKB=O67772	Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase	ISS			PTHR20858:SF17	HYDROXYMETHYLPYRIMIDINE/PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED
P00025	Hedgehog signaling pathway	P00690	Cubitus interruptus	DROME|FlyBase=FBgn0004859|UniProtKB=P19538	Transcriptional activator cubitus interruptus	IDA	9215627	PubMed	PTHR19818:SF124	TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00024	Glycolysis	P00678	Enolase	YEAST|SGD=S000004942|UniProtKB=P42222	Enolase-related protein 3	ISS	6324969	gi	PTHR11902:SF1	ENOLASE
P04393	Ras Pathway	P04542	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	TAKRU|Ensembl=ENSTRUG00000015938|UniProtKB=H2UUX5	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00059	p53 pathway	P04633	P110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01142	p90RSK	CHICK|Ensembl=ENSGALG00000000366|UniProtKB=P18652	Ribosomal protein S6 kinase 2 alpha	ISS	6755374	gi	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00059	p53 pathway	P04630	PP2A	MONDO|Ensembl=ENSMODG00000019001|UniProtKB=F7CP86	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01435	SWI/SNF	SYNY3|Gene=BAA18659|UniProtKB=P74552	Helicase of the snf2/rad54 family	ISS	11532957	PubMed	PTHR10799:SF810	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	CANLF|Ensembl=ENSCAFG00000003333|UniProtKB=F1PWT6	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MACMU|Ensembl=ENSMMUG00000000180|UniProtKB=F7HJM7	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00049	Parkinson disease	P01219	SAPK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00006	Apoptosis signaling pathway	P00269	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	P04609	PI3K	ANOGA|Gene=AgaP_AGAP010273|UniProtKB=Q7PMF0	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00020	FAS signaling pathway	P00612	Fas	MOUSE|MGI=MGI=95484|UniProtKB=P25446	Tumor necrosis factor receptor superfamily member 6	TAS	10327065	PubMed	PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P06587	Nicotine pharmacodynamics pathway	P06614	TH	HUMAN|HGNC=11782|UniProtKB=P07101	Tyrosine 3-monooxygenase	RCA	191290	OMIM	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00021	FGF signaling pathway	P00640	PI3K	CAEEL|WormBase=WBGene00006932|UniProtKB=Q9TXI7	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	11927551	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MOUSE|MGI=MGI=2150393|UniProtKB=Q91ZU9	Glutamate receptor ionotropic, NMDA 3B	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P00005	Angiogenesis	P00204	PLD	PANTR|Ensembl=ENSPTRG00000015626|UniProtKB=H2R1L6	Phospholipase D1, phosphatidylcholine-specific	ISS	10497874	PubMed	PTHR18896:SF57	PHOSPHOLIPASE D1
P06664	Gonadotropin-releasing hormone receptor pathway	P06768	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	RCA	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P05730	Endogenous cannabinoid signaling	P05748	mGluR	MACMU|Ensembl=ENSMMUG00000010184|UniProtKB=F6SR09	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00012	Cadherin signaling pathway	P00474	Wnt	MACMU|Ensembl=ENSMMUG00000015709|UniProtKB=F6SLX4	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00005	Angiogenesis	P00243	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00585	ECE1-3	PANTR|Ensembl=ENSPTRG00000013037|UniProtKB=H2R604	Uncharacterized protein	ISS	9931490	PubMed	PTHR11733:SF195	ENDOTHELIN-CONVERTING ENZYME-LIKE 1
P00019	Endothelin signaling pathway	P00590	IP3 R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	IC	1482697	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IDA	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00053	T cell activation	P01319	PAK	XENTR|Xenbase=XB-GENE-961764|UniProtKB=F6W3Y0	Uncharacterized protein	ISS	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=96274|UniProtKB=P28334	5-hydroxytryptamine receptor 1B	IDA	11701344	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P02778	Sulfate assimilation	P03164	Adenylylsulfate kinase	ECOLI|EcoGene=EG10185|UniProtKB=P0A6J1	Adenylyl-sulfate kinase	ISS			PTHR11055:SF27	ADENYLYL-SULFATE KINASE
P00029	Huntington disease	G01535	PIG3	DEIRA|EnsemblGenome=DR_1061|UniProtKB=Q9RVG8	NADPH quinone oxidoreductase, putative	TAS			PTHR43677:SF4	QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P00999	PSD95	MACMU|Ensembl=ENSMMUG00000019736|UniProtKB=F7B4V7	Uncharacterized protein	ISS	20020275	PubMed	PTHR24135:SF17	SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN 2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04657	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04620	TRAF	HUMAN|HGNC=12032|UniProtKB=Q12933	TNF receptor-associated factor 2	IDA	8069916	PubMed	PTHR10131:SF21	TNF RECEPTOR-ASSOCIATED FACTOR 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	TAS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PLAF7|EnsemblGenome=PFL2215w|UniProtKB=Q8I4X0	Actin-1	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	PANTR|Ensembl=ENSPTRG00000020706|UniProtKB=H2QWX3	Uncharacterized protein	ISS	8878477	PubMed	PTHR11829:SF191	FORKHEAD BOX PROTEIN H1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=94924|UniProtKB=P61168	D(2) dopamine receptor	IDA	2039532	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00047	PDGF signaling pathway	P01155	Jak	BOVIN|Ensembl=ENSBTAG00000003147|UniProtKB=F1N0D6	Tyrosine-protein kinase	ISS	11929133	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00047	PDGF signaling pathway	P01171	PLCgamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P06587	Nicotine pharmacodynamics pathway	P06605	KCNK3/9	RAT|RGD=61997|UniProtKB=O54912	Potassium channel subfamily K member 3	RCA	15282272	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P04393	Ras Pathway	P04566	Stat 1/3	RAT|RGD=3772|UniProtKB=P52631	Signal transducer and activator of transcription 3	IDA	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00011	Blood coagulation	P00414	Thrombin	MOUSE|MGI=MGI=88380|UniProtKB=P19221	Prothrombin	ISS	6753798	gi	PTHR24254:SF10	PROTHROMBIN
P00012	Cadherin signaling pathway	P00464	Fyn	RAT|RGD=2641|UniProtKB=Q62844	Tyrosine-protein kinase Fyn	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	RCA	15313841	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00056	VEGF signaling pathway	P01417	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT1G10210|UniProtKB=Q39021	Mitogen-activated protein kinase 1	ISS	94177172	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00047	PDGF signaling pathway	P01168	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	12660731	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04398	p53 pathway feedback loops 2	P04665	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00987	SRF	PANTR|Ensembl=ENSPTRG00000018189|UniProtKB=H2QT21	Uncharacterized protein	ISS	8660892	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00049	Parkinson disease	P01212	p38 MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00870	IL2	RAT|RGD=620047|UniProtKB=P17108	Interleukin-2	RCA			PTHR45426:SF1	INTERLEUKIN-2
P00046	Oxidative stress response	P01125	Stat1	HUMAN|HGNC=11362|UniProtKB=P42224	Signal transducer and activator of transcription 1-alpha/beta	TAS	10207096	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	ARATH|TAIR=AT3G48000|UniProtKB=Q9SU63	Aldehyde dehydrogenase family 2 member B4, mitochondrial	IC			PTHR11699:SF225	ALDEHYDE DEHYDROGENASE FAMILY 2 MEMBER B4, MITOCHONDRIAL
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00035	Interferon-gamma signaling pathway	P00961	STAT1	DANRE|ZFIN=ZDB-GENE-980526-499|UniProtKB=Q6P943	Signal transducer and activator of transcription	TAS	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00049	Parkinson disease	P01211	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000000820|UniProtKB=Q5E9F0	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	ISS			PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	MOUSE|MGI=MGI=1926879|UniProtKB=Q9EQH4	Transcription initiation factor TFIID subunit 8	ISS	604904	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MOUSE|MGI=MGI=87906|UniProtKB=P63260	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00048	PI3 kinase pathway	P01199	Galpha	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS			PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05913	Enkephalin release	P05974	G-Protein (i)	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	DICPU|Gene=DICPUDRAFT_51488|UniProtKB=F1A411	Putative uncharacterized protein rasC	ISS	8290260	PubMed	PTHR24070:SF251	RAS-LIKE PROTEIN RASC
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	10693759	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	PANTR|Ensembl=ENSPTRG00000010617|UniProtKB=H2QFL8	Notch 3	ISS	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00037	Ionotropic glutamate receptor pathway	P01026	KA	PANTR|Ensembl=ENSPTRG00000013825|UniProtKB=H2RAK4	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00018	EGF receptor signaling pathway	P00559	MEK1-2	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00010	B cell activation	P00398	IP3R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00029	Huntington disease	P00807	Actin	NEUCR|EnsemblGenome=EFNCRG00000003893|UniProtKB=P78711	Actin	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	IC	14698601	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04393	Ras Pathway	P04542	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	11313908	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P02727	Androgen/estrogene/progesterone biosynthesis	P02829	Cholesterol acyltransferase	MACMU|Ensembl=ENSMMUG00000003768|UniProtKB=F7GXC5	O-acyltransferase	ISS	9756918	PubMed	PTHR10408:SF6	STEROL O-ACYLTRANSFERASE 1
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	HUMAN|HGNC=1388|UniProtKB=O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	8386525	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P04398	p53 pathway feedback loops 2	G04714	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00053	T cell activation	P01311	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IDA	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00005	Angiogenesis	P00249	PAK	MONDO|Ensembl=ENSMODG00000005255|UniProtKB=F7G800	Uncharacterized protein	ISS	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CANLF|Ensembl=ENSCAFG00000009967|UniProtKB=F1PGZ2	Muscarinic acetylcholine receptor	ISS	10069496	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00029	Huntington disease	P00790	beta-Tubulin	PRIPA|Gene=PPA21757|UniProtKB=H3FHL0	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05915	Opioid proenkephalin pathway	P05991	Enkephalin	BOVIN|Ensembl=ENSBTAG00000004924|UniProtKB=P01211	Proenkephalin-A	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04393	Ras Pathway	P04579	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	7798194	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00036	Interleukin signaling pathway	P00980	IRS1/2	MACMU|Ensembl=ENSMMUG00000019467|UniProtKB=F6SUL3	Uncharacterized protein	ISS	15110093	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	CANLF|Ensembl=ENSCAFG00000004399|UniProtKB=E2RIL8	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF23	FRIZZLED-4
P00019	Endothelin signaling pathway	P00589	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00029	Huntington disease	P00799	JNK-2	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P02770	Pyridoxal phosphate salvage pathway	P03120	Pyridoxamine-5-phosphate oxidase	HUMAN|HGNC=30260|UniProtKB=Q9NVS9	Pyridoxine-5'-phosphate oxidase	ISS	9601034	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00010	B cell activation	P00391	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P01485	p53	DANRE|ZFIN=ZDB-GENE-030814-2|UniProtKB=B0S576	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00029	Huntington disease	P00790	beta-Tubulin	CANLF|Ensembl=ENSCAFG00000019807|UniProtKB=F2Z4P1	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Ensembl=ENSGALG00000026748|UniProtKB=F1P493	Uncharacterized protein	IEP	89264452	PubMed	PTHR13140:SF728	MYOSIN HEAVY CHAIN, SKELETAL MUSCLE, ADULT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00046	Oxidative stress response	P01138	MKK4	CHICK|Ensembl=ENSGALG00000001001|UniProtKB=F1P3T1	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P02749	Leucine biosynthesis	P03002	Isopropylmalate isomerase	METJA|EnsemblGenome=MJ_0499|UniProtKB=P81291	Isopropylmalate/citramalate isomerase large subunit	ISS			PTHR43822:SF2	HOMOACONITASE, MITOCHONDRIAL
P00029	Huntington disease	P00807	Actin	BOVIN|Gene=ACTB|UniProtKB=P60712	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P06664	Gonadotropin-releasing hormone receptor pathway	P06798	PKCe/theta	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	RCA	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00583	cPLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00006	Apoptosis signaling pathway	P00321	HSP70	HUMAN|HGNC=5235|UniProtKB=P54652	Heat shock-related 70 kDa protein 2	ISS	12150907	PubMed	PTHR19375:SF216	HEAT SHOCK-RELATED 70 KDA PROTEIN 2
P00029	Huntington disease	P00774	Dynein complex	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g236679|UniProtKB=A7RVI5	Predicted protein	ISS	9454836	PubMed	PTHR11886:SF62	DYNEIN, LIGHT CHAIN, LC8-TYPE 2
P00047	PDGF signaling pathway	P01171	PLCgamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00036	Interleukin signaling pathway	P00976	GSK3	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00030	Hypoxia response via HIF activation	P00823	PI3K	XENTR|Xenbase=XB-GENE-6067221|UniProtKB=F6Z0J4	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00589	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IGI	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	RAT|RGD=2735|UniProtKB=Q63273	Glutamate receptor ionotropic, kainate 5	ISS	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00059	p53 pathway	P04630	PP2A	BRAFL|Gene=BRAFLDRAFT_123893|UniProtKB=C3XQF4	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	TAKRU|Ensembl=ENSTRUG00000012885|UniProtKB=H2U6T8	Uncharacterized protein (Fragment)	IDA	6323229	PubMed	PTHR24248:SF0	ALPHA-2DA ADRENERGIC RECEPTOR-RELATED
P00057	Wnt signaling pathway	P01427	Naked	HUMAN|HGNC=17045|UniProtKB=Q969G9	Protein naked cuticle homolog 1	IDA	11356022	PubMed	PTHR22611:SF2	PROTEIN NAKED CUTICLE HOMOLOG 1
P00018	EGF receptor signaling pathway	P00542	EGFR	CHICK|Ensembl=ENSGALG00000003126|UniProtKB=F1P258	Receptor protein-tyrosine kinase	ISS	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00029	Huntington disease	P00786	ARF	RAT|RGD=621271|UniProtKB=P84082	ADP-ribosylation factor 2	ISS	12932731	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000014828|UniProtKB=F1N1E0	Uncharacterized protein	ISS	14507926	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P05918	p38 MAPK pathway	P06027	CREB	CHICK|Ensembl=ENSGALG00000008494|UniProtKB=Q7SX83	CAMP response element-binding protein	ISS	1354612	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00045	Notch signaling pathway	P01108	Nicastrin	PANTR|Ensembl=ENSPTRG00000001550|UniProtKB=H2Q0E4	Nicastrin	ISS	10993067	PubMed	PTHR21092:SF0	NICASTRIN
P00057	Wnt signaling pathway	P01468	APC	HUMAN|HGNC=24036|UniProtKB=O95996	Adenomatous polyposis coli protein 2	IDA	10491393	PubMed	PTHR12607:SF3	ADENOMATOUS POLYPOSIS COLI PROTEIN 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=97438|UniProtKB=P32300	Delta-type opioid receptor	IDA	11259498	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	ORNAN|Ensembl=ENSOANG00000011059|UniProtKB=F7FKP7	Uncharacterized protein	ISS			PTHR11405:SF38	CARBAMOYL-PHOSPHATE SYNTHASE  AMMONIA , MITOCHONDRIAL
P00047	PDGF signaling pathway	P01154	Ras	DICDI|dictyBase=DDB_G0281385|UniProtKB=P32253	Ras-like protein rasC	ISS	8290260	PubMed	PTHR24070:SF251	RAS-LIKE PROTEIN RASC
P00053	T cell activation	P01300	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347736|UniProtKB=E9FRT1	Muscle-specific actin	ISS	10974003	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	PANTR|Ensembl=ENSPTRG00000017389|UniProtKB=H2R334	Uncharacterized protein	ISS	12441358	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04413	K+ channel	BOVIN|Ensembl=ENSBTAG00000047488|UniProtKB=G3N1D1	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00034	Integrin signalling pathway	P00936	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IPI	96009592	PubMed	PTHR10048:SF14	PI-3 KINASE
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	TAKRU|Ensembl=ENSTRUG00000014690|UniProtKB=H2UKR9	Uncharacterized protein	IDA	12181435	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	RAT|RGD=69319|UniProtKB=P54313	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	CANLF|Ensembl=ENSCAFG00000009421|UniProtKB=F1PMK7	Uncharacterized protein	TAS	12834808	PubMed	PTHR10201:SF29	72 KDA TYPE IV COLLAGENASE
P04397	p53 pathway by glucose deprivation	P04636	S6K	CANLF|Ensembl=ENSCAFG00000011590|UniProtKB=E2R7K9	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	DROME|FlyBase=FBgn0026379|UniProtKB=Q7KMQ6	IP16020p	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00047	PDGF signaling pathway	P01154	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P04398	p53 pathway feedback loops 2	P04665	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	ARATH|TAIR=AT1G16710|UniProtKB=Q9FWQ5	Histone acetyltransferase HAC12	TAS	8413673	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00054	Toll receptor signaling pathway	P01356	ERK2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00875	GEF	MACMU|Ensembl=ENSMMUG00000001793|UniProtKB=F7GGR0	Cytohesin-2 isoform 2	ISS	11747824	PubMed	PTHR43935:SF4	CYTOHESIN-2
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	BOVIN|Ensembl=ENSBTAG00000019337|UniProtKB=F1MMW7	Receptor protein serine/threonine kinase	ISS			PTHR23255:SF58	ACTIVIN RECEPTOR TYPE-1C
P00050	Plasminogen activating cascade	P01246	Plasmin	MACMU|Gene=PLG|UniProtKB=P12545	Plasminogen	ISS	130317	gi	PTHR24261:SF6	PLASMINOGEN
P00021	FGF signaling pathway	P00624	14-3-3	MACMU|Ensembl=ENSMMUG00000013855|UniProtKB=F6RM85	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF14	14-3-3 PROTEIN SIGMA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	DAPPU|EnsemblGenome=DAPPUDRAFT_442795|UniProtKB=E9H5Z2	Calmodulin	ISS			PTHR23050:SF245	AT16150P-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00059	p53 pathway	G04703	Apaf	MACMU|Ensembl=ENSMMUG00000022404|UniProtKB=F6U0K7	Apoptotic protease-activating factor 1	ISS	14526190	PubMed	PTHR22845:SF5	APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	8946911	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00012	Cadherin signaling pathway	P00470	F-actin	DANRE|ZFIN=ZDB-GENE-000329-1|UniProtKB=Q7ZVI7	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00034	Integrin signalling pathway	P00941	Integrin alpha	HUMAN|HGNC=6138|UniProtKB=P08514	Integrin alpha-IIb	IPI	386753	gi	PTHR23220:SF73	INTEGRIN ALPHA-IIB
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00056	VEGF signaling pathway	P01407	Erk	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00326	FAS ligand	HUMAN|HGNC=11936|UniProtKB=P48023	Tumor necrosis factor ligand superfamily member 6	ISS	12787569	PubMed	PTHR11471:SF33	TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 6
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00801	Fos protein	BOVIN|Ensembl=ENSBTAG00000004322|UniProtKB=O77628	Proto-oncogene c-Fos	TAS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	TAS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00005	Angiogenesis	P00223	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	RAT|RGD=2917|UniProtKB=P15127	Insulin receptor	ISS	6754360	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	DANRE|ZFIN=ZDB-GENE-040625-167|UniProtKB=Q6IQP4	RAP1A, member of RAS oncogene family	ISS	8576107	PubMed	PTHR24070:SF284	RAP1A, MEMBER OF RAS ONCOGENE FAMILY
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000002647|UniProtKB=F7DIB7	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00048	PI3 kinase pathway	P01179	PKB	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	12086862	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00780	Microtubule	PRIPA|Gene=PPA02893|UniProtKB=H3DZP2	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF120	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00807	Actin	YARLI|EnsemblGenome=YALI0_D08272g|UniProtKB=Q9UVF3	Actin	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00012	Cadherin signaling pathway	P00467	alpha-catenin	MACMU|Ensembl=ENSMMUG00000000293|UniProtKB=F6YFG3	Uncharacterized protein	ISS	9362521	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00057	Wnt signaling pathway	P01465	Ggamma	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00046	Oxidative stress response	P01131	MKP5	MACMU|Ensembl=ENSMMUG00000023467|UniProtKB=F7EZU7	Uncharacterized protein	ISS			PTHR10159:SF25	INACTIVE DUAL SPECIFICITY PHOSPHATASE 27
P00057	Wnt signaling pathway	P01443	Phospholipase C	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	14744428	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04384	Gamma-aminobutyric acid synthesis	P04482	Glutamate decarboxylase	PANTR|Ensembl=ENSPTRG00000012626|UniProtKB=Q5IS68	Glutamate decarboxylase 1	ISS	2247446	PubMed	PTHR11999:SF57	GLUTAMATE DECARBOXYLASE 1
P00047	PDGF signaling pathway	P01140	ELK	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	9644975	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	IDA	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00029	Huntington disease	P00775	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12960248	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05976	Enkephalin	DANRE|ZFIN=ZDB-GENE-030729-31|UniProtKB=A8E7S2	Uncharacterized protein	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00035	Interferon-gamma signaling pathway	P00956	SOCS	MOUSE|MGI=MGI=1201787|UniProtKB=O35717	Suppressor of cytokine signaling 2	ISS	15032587	PubMed	PTHR44396:SF2	SUPPRESSOR OF CYTOKINE SIGNALING 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=97441|UniProtKB=P42866	Mu-type opioid receptor	IDA	11259487	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	PANTR|Ensembl=ENSPTRG00000013951|UniProtKB=H2QL34	Cystathionine beta-synthase	ISS			PTHR10314:SF8	CYSTATHIONINE BETA-SYNTHASE-RELATED
P04393	Ras Pathway	P04546	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IGI	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00164	Nectin 1alpha N-terminal fragment	MOUSE|MGI=MGI=1926483|UniProtKB=Q9JKF6	Nectin-1	IDA	12376527	PubMed	PTHR23277:SF69	NECTIN-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00049	Parkinson disease	P01240	hSel10	HUMAN|HGNC=16712|UniProtKB=Q969H0	F-box/WD repeat-containing protein 7	RCA			PTHR44007:SF6	F-BOX/WD REPEAT-CONTAINING PROTEIN 7
P00010	B cell activation	P00391	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00564	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00056	VEGF signaling pathway	P01414	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04398	p53 pathway feedback loops 2	P04668	p53	MOUSE|MGI=MGI=1330810|UniProtKB=O88898	Tumor protein 63	TAS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	ISS	91056091	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00005	Angiogenesis	P00240	FRS-2	CANLF|Ensembl=ENSCAFG00000000431|UniProtKB=E2QSI0	Uncharacterized protein	ISS	12571252	PubMed	PTHR21258:SF40	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	RAT|RGD=2091|UniProtKB=P09117	Fructose-bisphosphate aldolase C	ISS	7768978	PubMed	PTHR11627:SF3	FRUCTOSE-BISPHOSPHATE ALDOLASE C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MOUSE|MGI=MGI=87906|UniProtKB=P63260	Actin, cytoplasmic 2	ISS	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	XENTR|Xenbase=XB-GENE-957124|UniProtKB=F7BDN8	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00006	Apoptosis signaling pathway	P00302	ATF	BOVIN|Ensembl=ENSBTAG00000002295|UniProtKB=F1N177	Uncharacterized protein	ISS	11390664	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	PANTR|Ensembl=ENSPTRG00000014976|UniProtKB=H2R892	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00056	VEGF signaling pathway	P01422	eNOS	HUMAN|HGNC=7876|UniProtKB=P29474	Nitric oxide synthase, endothelial	IEP	93055452	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	CHICK|Ensembl=ENSGALG00000017238|UniProtKB=F1NWG3	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00053	T cell activation	P01322	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00023	General transcription regulation	P00658	TBP-associated factors	CHICK|Ensembl=ENSGALG00000003498|UniProtKB=Q5ZMS1	Transcription initiation factor TFIID subunit 8	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P04398	p53 pathway feedback loops 2	P04658	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00010	B cell activation	P00384	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00591	PLCbeta	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IGI	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00021	FGF signaling pathway	P00627	ERK1-2	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	ANOGA|EnsemblGenome=AGAP008908|UniProtKB=Q7PWN2	AGAP008908-PA	ISS	12963527	gi	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P00057	Wnt signaling pathway	P01443	Phospholipase C	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	MACMU|Ensembl=ENSMMUG00000014498|UniProtKB=F7GEI8	Uncharacterized protein	ISS	14507926	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=5299|UniProtKB=Q13639	5-hydroxytryptamine receptor 4	IDA			PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P00034	Integrin signalling pathway	P00941	Integrin alpha	HUMAN|HGNC=6135|UniProtKB=O75578	Integrin alpha-10	IPI	3487386	PubMed	PTHR23220:SF26	INTEGRIN ALPHA-10
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	ISS	8457205	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	MACMU|Ensembl=ENSMMUG00000019351|UniProtKB=Q2YEG0	C-X-C chemokine receptor type 1	ISS	9110929	PubMed	PTHR10489:SF916	C-X-C CHEMOKINE RECEPTOR TYPE 1
P00034	Integrin signalling pathway	P00916	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00021	FGF signaling pathway	P00627	ERK1-2	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00019	Endothelin signaling pathway	P00581	Guanylate cyclase	MACMU|Ensembl=ENSMMUG00000023244|UniProtKB=F7E689	Uncharacterized protein	RCA			PTHR11920:SF226	GUANYLATE CYCLASE SOLUBLE SUBUNIT ALPHA-3
P06664	Gonadotropin-releasing hormone receptor pathway	P06773	gnai/o	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	RCA	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00059	p53 pathway	P04616	PDK1/2	YEAST|SGD=S000002874|UniProtKB=Q03306	Serine/threonine-protein kinase PKH3	ISS			PTHR24356:SF238	SERINE/THREONINE-PROTEIN KINASE PKH3
P00047	PDGF signaling pathway	P01150	PKC	SCHPO|PomBase=SPBC12D12.04c|UniProtKB=P36583	Protein kinase C-like 2	ISS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00057	Wnt signaling pathway	P01438	PP2A	PANTR|Ensembl=ENSPTRG00000006734|UniProtKB=H2Q8X8	Uncharacterized protein	ISS	8576224	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00539	14-3-3	CIOIN|Ensembl=ENSCING00000008609|UniProtKB=F6TNW3	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000012005|UniProtKB=F7H091	Metabotropic glutamate receptor 2 isoform a	ISS	12351712	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00875	GEF	MOUSE|MGI=MGI=98923|UniProtKB=P27870	Proto-oncogene vav	IDA	10661401	PubMed	PTHR22826:SF112	PROTO-ONCOGENE VAV
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000022175|UniProtKB=F6XHY0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P00034	Integrin signalling pathway	P00947	Laminin	MOUSE|MGI=MGI=99912|UniProtKB=Q60675	Laminin subunit alpha-2	IPI	2538453	PubMed	PTHR10574:SF291	LAMININ SUBUNIT ALPHA-2
P00059	p53 pathway	P04609	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=1951|UniProtKB=P08172	Muscarinic acetylcholine receptor M2	IDA	12181435	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00057	Wnt signaling pathway	P01428	Frizzled	BOVIN|Ensembl=ENSBTAG00000002283|UniProtKB=F1N4K7	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF31	FRIZZLED-7
P00059	p53 pathway	G01575	GADD45	CANLF|Ensembl=ENSCAFG00000002174|UniProtKB=E2RK27	Uncharacterized protein	ISS	10097101	PubMed	PTHR10411:SF4	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 GAMMA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02723	Adenine and hypoxanthine salvage pathway	P02807	Deoxyadenosine deaminase	MACMU|Ensembl=ENSMMUG00000010603|UniProtKB=F7CBG9	Uncharacterized protein	ISS			PTHR11409:SF43	ADENOSINE DEAMINASE
P00018	EGF receptor signaling pathway	P00562	p38	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	4506785	gi	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00036	Interleukin signaling pathway	P00983	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00021	FGF signaling pathway	P00627	ERK1-2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	HUMAN|HGNC=288|UniProtKB=P13945	Beta-3 adrenergic receptor	IDA	12063255	PubMed	PTHR24248:SF3	BETA-3 ADRENERGIC RECEPTOR
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	176910	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000001583|UniProtKB=F7BBM1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IGI	7925653	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=12780|UniProtKB=P09544	Protein Wnt-2	IDA	8717036	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00050	Plasminogen activating cascade	P01253	Fibrin	CHICK|Ensembl=ENSGALG00000009268|UniProtKB=E1BV78	Uncharacterized protein	ISS	3641556	gi	PTHR19143:SF338	FIBRINOGEN GAMMA CHAIN
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	SCHMA|EnsemblGenome=Smp_046600|UniProtKB=G4VLW2	Putative actin-1	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	ISS	1482697	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00034	Integrin signalling pathway	P00923	Arf1	MOUSE|MGI=MGI=99431|UniProtKB=P84078	ADP-ribosylation factor 1	ISS	11752622	PubMed	PTHR11711:SF234	ADP-RIBOSYLATION FACTOR 1
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	XENTR|Ensembl=ENSXETG00000030841|UniProtKB=F7C5A3	Protein-serine/threonine kinase	ISS	10852916	PubMed	PTHR24355:SF18	PROTEIN-SERINE/THREONINE KINASE
P02749	Leucine biosynthesis	P03001	3-Isopropylmalate dehydrogenase	BACSU|EnsemblGenome=BSU28270|UniProtKB=P05645	3-isopropylmalate dehydrogenase	ISS			PTHR42979:SF1	3-ISOPROPYLMALATE DEHYDROGENASE
P00021	FGF signaling pathway	P00640	PI3K	CANAL|CGD=CAL0068551|UniProtKB=Q5AAR9	Phosphatidylinositol 3-kinase	IGI	10870104	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00054	Toll receptor signaling pathway	P01375	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00019	Endothelin signaling pathway	P00583	cPLA2	CHICK|Ensembl=ENSGALG00000005065|UniProtKB=P49147	Cytosolic phospholipase A2	IGI	94299545	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	CHICK|Gene_ORFName=RCJMB04_24e7|UniProtKB=P62149	Calmodulin	ISS	9753452	PubMed	PTHR23050:SF311	CALMODULIN
P00019	Endothelin signaling pathway	P00586	Gq	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00035	Interferon-gamma signaling pathway	P00959	IFNGR1	HUMAN|HGNC=5439|UniProtKB=P15260	Interferon gamma receptor 1	TAS	14525967	PubMed	PTHR20859:SF5	INTERFERON GAMMA RECEPTOR 1
P05918	p38 MAPK pathway	P06029	p38beta	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00047	PDGF signaling pathway	P01151	PKB	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00010	B cell activation	P00373	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	DANRE|ZFIN=ZDB-GENE-010319-1|UniProtKB=B8JMI2	Uncharacterized protein	TAS	11212302	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P05913	Enkephalin release	P05972	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00010	B cell activation	P00391	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00057	Wnt signaling pathway	P01451	Galpha	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g188243|UniProtKB=A7SCN8	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00006	Apoptosis signaling pathway	P00269	MAPK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	HUMAN|HGNC=9300|UniProtKB=P62714	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	ISS	22097630	PubMed	PTHR24070:SF189	GTPASE NRAS
P00053	T cell activation	P01305	Calmodulin	DANRE|Ensembl=ENSDARG00000015050|UniProtKB=Q6PI52	Calmodulin	ISS	10487978	PubMed	PTHR23050:SF326	CALMODULIN
P04398	p53 pathway feedback loops 2	P04657	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00777	CBP	ARATH|TAIR=AT1G79000|UniProtKB=Q9C5X9	Histone acetyltransferase HAC1	IDA	10823891	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00010	B cell activation	P00373	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IDA	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00034	Integrin signalling pathway	P00920	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00048	PI3 kinase pathway	P01199	Galpha	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	IC			PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P04393	Ras Pathway	P04553	PAK	MOUSE|MGI=MGI=1339984|UniProtKB=Q8CIN4	Serine/threonine-protein kinase PAK 2	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00019	Endothelin signaling pathway	P00571	Pro ET1-4	BOVIN|Ensembl=ENSBTAG00000008096|UniProtKB=P17322	Endothelin-1	ISS			PTHR13874:SF10	ENDOTHELIN-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00005	Angiogenesis	P00220	c-Jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	MOUSE|MGI=MGI=109284|UniProtKB=Q61144	Presenilin-2	IDA	12885769	PubMed	PTHR10202:SF13	PRESENILIN-2
P00018	EGF receptor signaling pathway	P00555	MKK4,7	CHICK|Ensembl=ENSGALG00000001001|UniProtKB=F1P3T1	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00018	EGF receptor signaling pathway	P00543	ERK1-2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IDA	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05731	GABA-B receptor II signaling	P05755	Gbeta	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00021	FGF signaling pathway	P00630	RKIP	CAEEL|WormBase=WBGene00018218|UniProtKB=O16264	Phosphatidylethanolamine-binding protein homolog F40A3.3	ISS			PTHR11362:SF28	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	ENTHI|EnsemblGenome=EHI_197840|UniProtKB=C4M8K6	Rho family GTPase	ISS	4757952	gi	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P02756	N-acetylglucosamine metabolism	P03041	Glucosamine-6-phosphate deaminase	RAT|RGD=1305521|UniProtKB=B5DEZ6	Glucosamine-6-phosphate isomerase	ISS			PTHR11280:SF9	GLUCOSAMINE-6-PHOSPHATE ISOMERASE 2
P00021	FGF signaling pathway	P00629	PP2A	MOUSE|MGI=MGI=1321159|UniProtKB=P63330	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00920	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04426	K+ channel	MACMU|Ensembl=ENSMMUG00000005826|UniProtKB=F6VE51	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00057	Wnt signaling pathway	P01437	TCF	CANLF|Ensembl=ENSCAFG00000011252|UniProtKB=F1Q334	Uncharacterized protein	ISS	9039917	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00006	Apoptosis signaling pathway	P00303	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	12972619	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00170	Aph-1	MOUSE|MGI=MGI=1915568|UniProtKB=Q9DCZ9	Putative gamma-secretase subunit APH-1C	IDA	12110170	PubMed	PTHR12889:SF1	GAMMA-SECRETASE SUBUNIT APH-1B
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	ANOGA|EnsemblGenome=AGAP006475|UniProtKB=Q5TQX0	AGAP006475-PA	ISS	9065779	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00010	B cell activation	P00376	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00059	p53 pathway	P01486	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	TAS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00049	Parkinson disease	P01238	14-3-3	EMENI|EnsemblGenome=CADANIAG00005943|UniProtKB=Q5B4M9	1433_TRIHA 14-3-3 PROTEIN HOMOLOG (TH1433)	IDA	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P04398	p53 pathway feedback loops 2	P04657	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	CANLF|Ensembl=ENSCAFG00000012923|UniProtKB=F1PEK4	Uncharacterized protein	ISS			PTHR44107:SF3	DOWN SYNDROME CELL ADHESION MOLECULE-LIKE PROTEIN 1
P00036	Interleukin signaling pathway	P00996	STAT	PANTR|Ensembl=ENSPTRG00000009199|UniProtKB=H2QD19	Signal transducer and activator of transcription	ISS	14662325	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	DROME|FlyBase=FBgn0040206|UniProtKB=Q9V393	Kurtz arrestin	ISS	9388255	PubMed	PTHR11792:SF17	KURTZ ARRESTIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000040253|UniProtKB=F1MGA6	Uncharacterized protein	ISS			PTHR24248:SF17	ALPHA-1B ADRENERGIC RECEPTOR
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	RAT|RGD=621060|UniProtKB=O88777	Presenilin-2	TAS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P05734	Synaptic vesicle trafficking	P05770	Munc18	MOUSE|MGI=MGI=107363|UniProtKB=O08599	Syntaxin-binding protein 1	ISS	8108429	PubMed	PTHR11679:SF35	SYNTAXIN-BINDING PROTEIN 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01336	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00786	ARF	DANRE|ZFIN=ZDB-GENE-030131-5234|UniProtKB=Q7ZUZ7	ADP-ribosylation factor 1	ISS	11752622	PubMed	PTHR11711:SF291	ADP-RIBOSYLATION FACTOR 1
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00052	TGF-beta signaling pathway	P01292	RSmads	BOVIN|Ensembl=ENSBTAG00000002835|UniProtKB=Q1JQA2	Mothers against decapentaplegic homolog 1	ISS	12736218	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P05918	p38 MAPK pathway	P06028	MLK2	MOUSE|MGI=MGI=1346879|UniProtKB=Q66L42	Mitogen-activated protein kinase kinase kinase 10	ISS	9639556	PubMed	PTHR43997:SF5	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00828	Galphai	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	RCA			PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00034	Integrin signalling pathway	P00940	Src	TAKRU|Ensembl=ENSTRUG00000004669|UniProtKB=H2SFA3	Tyrosine-protein kinase	IPI	11078745	PubMed	PTHR24418:SF181	TYROSINE-PROTEIN KINASE BLK
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	PANTR|Ensembl=ENSPTRG00000020589|UniProtKB=H2QWQ6	Uncharacterized protein	ISS	8163524	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MACMU|Ensembl=ENSMMUG00000009938|UniProtKB=F6RJH8	Uncharacterized protein	ISS			PTHR13140:SF421	UNCONVENTIONAL MYOSIN-XVIIIA
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00912	Arp2/3	MOUSE|MGI=MGI=1928375|UniProtKB=Q9JM76	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00572	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00017	DNA replication	P00535	5' to 3' Exoribonulcease	DROME|FlyBase=FBgn0031868|UniProtKB=Q9VM71	5'-3' exoribonuclease 2 homolog	TAS	22426070	PubMed	PTHR12341:SF41	5'-3' EXORIBONUCLEASE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	DANRE|ZFIN=ZDB-GENE-010705-1|UniProtKB=Q90Z40	Guanine nucleotide-binding protein subunit gamma	IDA	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00057	Wnt signaling pathway	P01428	Frizzled	MACMU|Ensembl=ENSMMUG00000006912|UniProtKB=F7EZ48	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF86	FRIZZLED-10
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	METJA|EnsemblGenome=MJ_1378|UniProtKB=Q58773	Carbamoyl-phosphate synthase large chain, N-terminal section	ISS			PTHR11405:SF5	CAD PROTEIN
P00052	TGF-beta signaling pathway	P01286	TGFbeta	HUMAN|HGNC=3122|UniProtKB=O00292	Left-right determination factor 2	TAS	9759503	PubMed	PTHR11848:SF232	LEFT-RIGHT DETERMINATION FACTOR 2
P00018	EGF receptor signaling pathway	P00558	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	IGI	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04570	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=109485|UniProtKB=Q9WUD6	Protein Wnt-8b	IDA	8717036	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CAEBR|Gene=CBG01949|UniProtKB=A8WRN3	Protein CBR-MGL-1 (Fragment)	ISS	12351712	PubMed	PTHR24060:SF137	METABOTROPIC GLUTAMATE RECEPTOR
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	PHYPA|Gene=PHYPADRAFT_218940|UniProtKB=A9T4Y7	Predicted protein	ISS	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01179	PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	CAEEL|WormBase=WBGene00006742|UniProtKB=G4SFC3	Uncharacterized protein	ISS	8386525	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	LEIMA|EnsemblGenome=LmjF.35.3960|UniProtKB=E9AFM1	Protein kinase A catalytic subunit isoform 2	ISS	10553940	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IDA	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00221	JNK1	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02776	Serine glycine biosynthesis	P03160	Phosphoglycerate dehydrogenase	ARATH|TAIR=AT1G17745|UniProtKB=O04130	D-3-phosphoglycerate dehydrogenase 2, chloroplastic	ISS			PTHR42938:SF5	D-3-PHOSPHOGLYCERATE DEHYDROGENASE
P00049	Parkinson disease	P01238	14-3-3	ORNAN|Ensembl=ENSOANG00000006084|UniProtKB=F7BU66	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF14	14-3-3 PROTEIN SIGMA
P00021	FGF signaling pathway	P00634	MEKK1-5	BOVIN|Ensembl=ENSBTAG00000020079|UniProtKB=F1N3T0	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	HUMAN|HGNC=145|UniProtKB=P63267	Actin, gamma-enteric smooth muscle	IC	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00029	Huntington disease	P00796	Kainate receptor	PANTR|Ensembl=ENSPTRG00000000543|UniProtKB=H2PYN8	Uncharacterized protein	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	HUMAN|HGNC=1401|UniProtKB=Q02641	Voltage-dependent L-type calcium channel subunit beta-1	IC	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00068	amine translocator	HUMAN|HGNC=26441|UniProtKB=Q96N87	Sodium-dependent neutral amino acid transporter B(0)AT3	IC	12719981	PubMed	PTHR11616:SF109	SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER B 0 AT3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	IDA	11591316	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	MONDO|Ensembl=ENSMODG00000016960|UniProtKB=F6V5G0	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00012	Cadherin signaling pathway	P00470	F-actin	XENTR|Xenbase=XB-GENE-490883|UniProtKB=Q6NVA9	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00796	Kainate receptor	MOUSE|MGI=MGI=95815|UniProtKB=P39087	Glutamate receptor ionotropic, kainate 2	IDA	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00053	T cell activation	P01311	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P06001	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	RAT|RGD=621346|UniProtKB=Q2IBD1	Protein Wnt	TAS	8717036	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00011	Blood coagulation	P00458	GP IIIa	MOUSE|MGI=MGI=96612|UniProtKB=O54890	Integrin beta-3	ISS	5805343	gi	PTHR10082:SF25	INTEGRIN BETA-3
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00059	p53 pathway	P04630	PP2A	XENTR|Xenbase=XB-GENE-484003|UniProtKB=Q6P365	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01275	P38	CAEEL|WormBase=WBGene00004056|UniProtKB=Q8MXI4	Mitogen-activated protein kinase pmk-2	TAS	11707292	PubMed	PTHR24055:SF154	MITOGEN-ACTIVATED PROTEIN KINASE PMK-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MACMU|Ensembl=ENSMMUG00000003486|UniProtKB=F7E7H3	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF34	REGULATOR OF G-PROTEIN SIGNALING 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	IGI	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00023	General transcription regulation	P00666	TFIIE	CANLF|Ensembl=ENSCAFG00000011306|UniProtKB=E2R3P2	Uncharacterized protein	ISS	189964	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00005	Angiogenesis	P00223	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	RCA			PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00007	Axon guidance mediated by semaphorins	P00338	Neuropilin 1	BOVIN|Ensembl=ENSBTAG00000019866|UniProtKB=E1BMX5	Uncharacterized protein	ISS	9288754	PubMed	PTHR44185:SF1	NEUROPILIN-1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	IC	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00004	Alzheimer disease-presenilin pathway	P00168	E-cadherin intracellular fragment	RAT|RGD=69279|UniProtKB=Q9R0T4	Cadherin-1	IDA	12834808	PubMed	PTHR24027:SF319	CADHERIN-1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-040718-134|UniProtKB=Q6DH55	Guanine nucleotide binding protein (G protein), beta polypeptide 3, like	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	CHICK|Gene=FZD1|UniProtKB=O57328	Frizzled-1	TAS	11212302	PubMed	PTHR11309:SF81	FRIZZLED-1
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00036	Interleukin signaling pathway	P00990	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01351	TLR2,4,7	HUMAN|HGNC=11850|UniProtKB=O00206	Toll-like receptor 4	ISS			PTHR44568:SF1	TOLL-LIKE RECEPTOR 4
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04392	P53 pathway feedback loops 1	G04686	p73	MOUSE|MGI=MGI=1336991|UniProtKB=Q9JJP2	Tumor protein p73	ISS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00059	p53 pathway	G04694	p110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	BOVIN|Ensembl=ENSBTAG00000012687|UniProtKB=F1MV64	Tyrosine-protein kinase receptor	ISS	2983222	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P05917	Opioid proopiomelanocortin pathway	P06011	AC	RAT|RGD=619966|UniProtKB=F1LQT1	Adenylate cyclase 7	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00034	Integrin signalling pathway	P00922	Collagen	HUMAN|HGNC=2203|UniProtKB=P08572	Collagen alpha-2(IV) chain	IDA	10778855	PubMed	PTHR24023:SF588	COLLAGEN ALPHA-2 IV  CHAIN
P05918	p38 MAPK pathway	P06020	p38delta	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	RCA	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	SCHPO|PomBase=SPBC12D12.04c|UniProtKB=P36583	Protein kinase C-like 2	TAS	125549	gi	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00048	PI3 kinase pathway	P01179	PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	RAT|RGD=3772|UniProtKB=P52631	Signal transducer and activator of transcription 3	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00760	Gtalpha	BOVIN|Ensembl=ENSBTAG00000018020|UniProtKB=P04695	Guanine nucleotide-binding protein G(t) subunit alpha-1	IDA	10188796	PubMed	PTHR10218:SF67	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-1
P04393	Ras Pathway	P04564	MAPKAP	PANTR|Ensembl=ENSPTRG00000014968|UniProtKB=H2QMP5	Mitogen-activated protein kinase-activated protein kinase 3	ISS	11335727	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P00058	mRNA splicing	P01476	U4	HUMAN|HGNC=17348|UniProtKB=O43395	U4/U6 small nuclear ribonucleoprotein Prp3	IDA	9328476	PubMed	PTHR14212:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3
P00034	Integrin signalling pathway	P00948	Rho	PANTR|Ensembl=ENSPTRG00000004888|UniProtKB=H2Q5T9	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF23	RHO-RELATED GTP-BINDING PROTEIN RHO6
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00052	TGF-beta signaling pathway	P01286	TGFbeta	HUMAN|HGNC=4220|UniProtKB=P43026	Growth/differentiation factor 5	TAS	9759503	PubMed	PTHR11848:SF44	GROWTH/DIFFERENTIATION FACTOR 5
P02726	Aminobutyrate degradation	P02825	4-aminobutyrate aminotransferase	MYCTU|EnsemblGenome=Rv2589|UniProtKB=P9WQ79	4-aminobutyrate aminotransferase	ISS			PTHR43206:SF2	4-AMINOBUTYRATE AMINOTRANSFERASE GABT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	XENTR|GeneID=394982|UniProtKB=P20399	Actin, alpha cardiac muscle 2	ISS	10974003	PubMed	PTHR11937:SF263	ACTIN
P00021	FGF signaling pathway	P00646	RasGAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	8262392	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06831	p38	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	RCA	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00048	PI3 kinase pathway	P01182	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	TAS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00048	PI3 kinase pathway	P01199	Galpha	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	DROME|FlyBase=FBgn0010399|UniProtKB=Q24418	Glutamate [NMDA] receptor subunit 1	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00013	Cell cycle	P00489	CdkC	RAT|RGD=1307783|UniProtKB=D3ZQ41	Cyclin E2 (Predicted)	RCA			PTHR10177:SF70	G1/S-SPECIFIC CYCLIN-E2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	10514528	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IC	22533439	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IDA	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00047	PDGF signaling pathway	P01159	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01062	mGluR1	RAT|RGD=2742|UniProtKB=P23385	Metabotropic glutamate receptor 1	ISS	8314195	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00045	Notch signaling pathway	P01119	NIct	CANLF|Ensembl=ENSCAFG00000019633|UniProtKB=F1PDC7	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00006	Apoptosis signaling pathway	P00318	PKCs	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	MOUSE|MGI=MGI=1339975|UniProtKB=O88643	Serine/threonine-protein kinase PAK 1	ISS	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	IDA	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00057	Wnt signaling pathway	P01455	Smad4	PANTR|Ensembl=ENSPTRG00000010028|UniProtKB=H2QEJ6	Mothers against decapentaplegic homolog	ISS	10693808	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P00018	EGF receptor signaling pathway	P00555	MKK4,7	CANLF|Ensembl=ENSCAFG00000017851|UniProtKB=F1PBB6	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	CAEEL|WormBase=WBGene00002189|UniProtKB=P21137	cAMP-dependent protein kinase catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00046	Oxidative stress response	P01135	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	BOVIN|Ensembl=ENSBTAG00000009245|UniProtKB=Q0P594	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01448	CBP	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	IDA	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	11591316	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00005	Angiogenesis	P00221	JNK1	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00205	GAP	HUMAN|HGNC=9871|UniProtKB=P20936	Ras GTPase-activating protein 1	IDA	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P05913	Enkephalin release	P05972	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00008	Axon guidance mediated by Slit/Robo	P00344	Netrin	PANTR|Ensembl=ENSPTRG00000021493|UniProtKB=H2QY29	Uncharacterized protein	ISS			PTHR10574:SF27	NETRIN-G2
P00046	Oxidative stress response	P01135	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000005950|UniProtKB=E1BDC1	Uncharacterized protein	ISS			PTHR45535:SF1	MELATONIN-RELATED RECEPTOR
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00912	Arp2/3	BOVIN|Ensembl=ENSBTAG00000005345|UniProtKB=Q3T035	Actin-related protein 2/3 complex subunit 3	ISS	12473693	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00046	Oxidative stress response	P01135	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	12810719	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MACMU|Ensembl=ENSMMUG00000001661|UniProtKB=F7GR69	Uncharacterized protein	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P06959	CCKR signaling map	P07053	IKBalpha	HUMAN|HGNC=7797|UniProtKB=P25963	NF-kappa-B inhibitor alpha	RCA	11983155	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05938	RhoA	MONDO|Ensembl=ENSMODG00000012981|UniProtKB=F7CS91	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	MOUSE|MGI=MGI=106028|UniProtKB=Q62159	Rho-related GTP-binding protein RhoC	IDA	12090470	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	ARATH|TAIR=AT4G17640|UniProtKB=P40229	Casein kinase II subunit beta'	IDA	10806215	PubMed	PTHR11740:SF15	CASEIN KINASE II SUBUNIT BETA-RELATED
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=1754|UniProtKB=P55291	Cadherin-15	IDA	8120095	PubMed	PTHR24027:SF300	CADHERIN-15
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00021	FGF signaling pathway	P00630	RKIP	HUMAN|HGNC=8630|UniProtKB=P30086	Phosphatidylethanolamine-binding protein 1	ISS	92031654	PubMed	PTHR11362:SF28	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P00047	PDGF signaling pathway	P01163	c-Jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00010	B cell activation	P00383	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00045	Notch signaling pathway	P01108	Nicastrin	CANLF|Ensembl=ENSCAFG00000012557|UniProtKB=F1PU73	Uncharacterized protein	ISS	16096062	PubMed	PTHR21092:SF0	NICASTRIN
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00115	Nicastrin	RAT|RGD=631418|UniProtKB=Q8CGU6	Nicastrin	IDA	10993067	PubMed	PTHR21092:SF0	NICASTRIN
P00011	Blood coagulation	P00408	Plasminogen	RAT|RGD=619893|UniProtKB=Q01177	Plasminogen	ISS	16758216	gi	PTHR24261:SF5	PLASMINOGEN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02738	De novo purine biosynthesis	P02904	Guanylate kinase	MOUSE|MGI=MGI=95871|UniProtKB=Q64520	Guanylate kinase	ISS			PTHR23117:SF13	GUANYLATE KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06841	gnaq/11	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	RCA	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02781	Threonine biosynthesis	P03189	Aspartate kinase	BACSU|EnsemblGenome=BSU16760|UniProtKB=Q04795	Aspartokinase 1	ISS			PTHR21499:SF41	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04661	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00778	NMDA receptor	MOUSE|MGI=MGI=95823|UniProtKB=Q03391	Glutamate receptor ionotropic, NMDA 2D	IDA	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P02723	Adenine and hypoxanthine salvage pathway	P02813	Inosine phosphorylase	PANTR|Ensembl=ENSPTRG00000006095|UniProtKB=H2Q7W4	Purine nucleoside phosphorylase	ISS			PTHR11904:SF12	PURINE NUCLEOSIDE PHOSPHORYLASE
P00059	p53 pathway	G04703	Apaf	BOVIN|Ensembl=ENSBTAG00000021661|UniProtKB=F1MUW4	Apoptotic protease-activating factor 1	ISS	9267021	PubMed	PTHR22845:SF5	APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
P05916	Opioid prodynorphin pathway	P06002	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00038	JAK/STAT signaling pathway	P01031	PIAS	PANTR|Ensembl=ENSPTRG00000009998|UniProtKB=H2QEH6	Uncharacterized protein	ISS	8682149	PubMed	PTHR10782:SF12	E3 SUMO-PROTEIN LIGASE PIAS2
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00056	VEGF signaling pathway	P01425	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P04398	p53 pathway feedback loops 2	P04658	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00037	Ionotropic glutamate receptor pathway	P00998	stargazin	RAT|RGD=71095|UniProtKB=Q71RJ2	Voltage-dependent calcium channel gamma-2 subunit	RCA			PTHR12107:SF1	VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-2 SUBUNIT
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00020	FAS signaling pathway	P00615	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00029	Huntington disease	P00786	ARF	ARATH|TAIR=AT5G17060|UniProtKB=Q9LFJ7	ADP-ribosylation factor B1B	IPI	12932731	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04396	Vitamin D metabolism and pathway	G04688	24-Hydroxylase	RAT|RGD=2462|UniProtKB=Q09128	1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	IDA	11686044	PubMed	PTHR24291:SF5	1,25-DIHYDROXYVITAMIN D 3  24-HYDROXYLASE, MITOCHONDRIAL
P00056	VEGF signaling pathway	P01423	p38MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02775	Salvage pyrimidine ribonucleotides	P03152	Uridine phosphorylase	RAT|RGD=1305566|UniProtKB=Q499V1	Uridine phosphorylase	ISS			PTHR43691:SF3	URIDINE PHOSPHORYLASE 1
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00021	FGF signaling pathway	P00627	ERK1-2	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00568	PKC	SCHPO|PomBase=SPBC12D12.04c|UniProtKB=P36583	Protein kinase C-like 2	IGI	8491190	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00010	B cell activation	P00384	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00054	Toll receptor signaling pathway	P01367	MKK3	ORNAN|Ensembl=ENSOANG00000007732|UniProtKB=F6PXH5	Uncharacterized protein (Fragment)	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IPI	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00114	actin	SCLS1|Gene=SS1G_08733|UniProtKB=A7ETS6	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IDA	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	DANRE|ZFIN=ZDB-GENE-000330-9|UniProtKB=Q90ZE4	Presenilin-2	IDA	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00010	B cell activation	P00381	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00181	SHP2	TAKRU|Ensembl=ENSTRUG00000018529|UniProtKB=H2VDZ2	Tyrosine-protein phosphatase non-receptor type	ISS	1382983	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00024	Glycolysis	P00679	Aldolase	MACMU|Ensembl=ENSMMUG00000000983|UniProtKB=F6SYL4	Fructose-bisphosphate aldolase	ISS	6086339	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00029	Huntington disease	P00807	Actin	DANRE|ZFIN=ZDB-GENE-040426-2894|UniProtKB=Q7SXW6	Actin-related protein 2-A	ISS	10974003	PubMed	PTHR11937:SF149	ACTIN-RELATED PROTEIN 2-A-RELATED
P05731	GABA-B receptor II signaling	P05754	Ggamma	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00009	Axon guidance mediated by netrin	P00363	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04393	Ras Pathway	P04546	GSK3	MACMU|Ensembl=ENSMMUG00000014597|UniProtKB=F6VAQ6	Glycogen synthase kinase-3 alpha	ISS	11995474	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00034	Integrin signalling pathway	P00907	ERK	RAT|RGD=1311192|UniProtKB=A0A0G2K3R1	Protein Map3k4	ISS			PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00029	Huntington disease	P00775	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00029	Huntington disease	P00774	Dynein complex	CAEBR|Gene=CBG12193|UniProtKB=A8XF10	Protein CBR-DHC-1	ISS	9454836	PubMed	PTHR10676:SF314	CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02783	Tryptophan biosynthesis	P03208	Tryptophan synthase B	CHLTR|EnsemblGenome=CT_170|UniProtKB=O84172	Tryptophan synthase beta chain	ISS			PTHR42882:SF1	TRYPTOPHAN SYNTHASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS			PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01167	Ets	PANTR|Ensembl=ENSPTRG00000001486|UniProtKB=A2T762	ETS translocation variant 3	ISS	15298723	PubMed	PTHR11849:SF30	ETS TRANSLOCATION VARIANT 3
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00053	T cell activation	P01311	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IDA	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00968	Ikk	CANLF|Ensembl=ENSCAFG00000009588|UniProtKB=E2RNA9	Uncharacterized protein	ISS	14499113	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IC	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	HUMAN|HGNC=9508|UniProtKB=P49768	Presenilin-1	TAS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000020947|UniProtKB=F7CY46	Uncharacterized protein	ISS	12562507	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00006	Apoptosis signaling pathway	P00274	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01465	Ggamma	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	MACMU|Ensembl=ENSMMUG00000018497|UniProtKB=F7A9J8	Serine/threonine-protein kinase receptor	ISS	9395284	PubMed	PTHR23255:SF69	ACTIVIN RECEPTOR TYPE-1
P00057	Wnt signaling pathway	P01432	Beta-Catenin	PANTR|Ensembl=ENSPTRG00000023062|UniProtKB=H2R2U1	Catenin (Cadherin-associated protein), beta 1, 88kDa	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04398	p53 pathway feedback loops 2	P04657	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00054	Toll receptor signaling pathway	P01368	MKK2	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00009	Axon guidance mediated by netrin	P00363	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00239	Eph	HUMAN|HGNC=3226|UniProtKB=P98172	Ephrin-B1	ISS			PTHR11304:SF17	EPHRIN-B1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	RAT|RGD=1359485|UniProtKB=Q5U302	Catenin (Cadherin associated protein), alpha 1	ISS	1768802	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04395	Vasopressin synthesis	P04590	Vasopressin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	CHICK|Ensembl=ENSGALG00000012755|UniProtKB=P18254	Insulin-like growth factor I	ISS			PTHR11454:SF4	INSULIN-LIKE GROWTH FACTOR I
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	RCA	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00019	Endothelin signaling pathway	P00591	PLCbeta	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	CAEEL|WormBase=WBGene00016509|UniProtKB=P91134	Adenylosuccinate synthetase	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00005	Angiogenesis	P00254	GTPase	TAKRU|Ensembl=ENSTRUG00000011944|UniProtKB=H2TZX5	Uncharacterized protein	ISS	10556059	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IDA	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00020	FAS signaling pathway	P00615	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01471	alpha-catenin	PANTR|Ensembl=ENSPTRG00000021235|UniProtKB=H2QXN7	Uncharacterized protein	ISS	9362521	PubMed	PTHR18914:SF8	ALPHA-CATULIN
P00034	Integrin signalling pathway	P00944	Actin	HUMAN|HGNC=144|UniProtKB=P63261	Actin, cytoplasmic 2	IPI	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00036	Interleukin signaling pathway	P00981	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00004	Alzheimer disease-presenilin pathway	P00137	Tip60	RAT|RGD=621061|UniProtKB=Q99MK2	Histone acetyltransferase KAT5	ISS	11441186	PubMed	PTHR10615:SF124	HISTONE ACETYLTRANSFERASE KAT5
P02785	Valine biosynthesis	P03215	Branched chain amino acid aminotransferase	ORYSJ|EnsemblGenome=OS05G0558400|UniProtKB=Q6AT43	Branched-chain-amino-acid aminotransferase	ISS			PTHR42825:SF3	SUBFAMILY NOT NAMED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P06211	BMP/activin signaling pathway-drosophila	P06246	NEJ	DROME|FlyBase=FBgn0261617|UniProtKB=M9MS40	Nejire, isoform C	IGI	10075933	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS			PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00011	Blood coagulation	P00429	PN2	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	ISS	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P02748	Isoleucine biosynthesis	P02996	Ketol-acid reductoisomerase	STRCO|EnsemblGenome=CAB37590|UniProtKB=Q9Z565	Ketol-acid reductoisomerase 1	ISS			PTHR21371:SF1	KETOL-ACID REDUCTOISOMERASE, CHLOROPLASTIC
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00049	Parkinson disease	P01211	ERK	DICDI|dictyBase=DDB_G0283903|UniProtKB=Q54QB1	Extracellular signal-regulated kinase 2	IDA	10851062	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00047	PDGF signaling pathway	P01143	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00052	TGF-beta signaling pathway	P01275	P38	DROME|FlyBase=FBgn0024846|UniProtKB=O61443	Mitogen-activated protein kinase 14B	TAS	11274345	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00059	p53 pathway	P04633	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01276	Co-Smads	RAT|RGD=3033|UniProtKB=O70437	Mothers against decapentaplegic homolog 4	TAS	10693808	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DANRE|ZFIN=ZDB-GENE-010705-1|UniProtKB=Q90Z40	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	CHICK|Ensembl=ENSGALG00000006885|UniProtKB=P08642	GTPase HRas	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	BOVIN|Ensembl=ENSBTAG00000007882|UniProtKB=G3X7Z2	Uncharacterized protein	IDA	15079861	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DANRE|ZFIN=ZDB-GENE-040426-1354|UniProtKB=Q7T2C5	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CANLF|Ensembl=ENSCAFG00000003333|UniProtKB=F1PWT6	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	MACMU|Ensembl=ENSMMUG00000021312|UniProtKB=F6UYD0	Uncharacterized protein	ISS			PTHR10024:SF115	SYNAPTOTAGMIN-11
P00005	Angiogenesis	P00205	GAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00018	EGF receptor signaling pathway	P00561	STAT	PANTR|Ensembl=ENSPTRG00000009200|UniProtKB=H2QD20	Signal transducer and activator of transcription	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00013	Cell cycle	P00480	Proteasome	DANRE|ZFIN=ZDB-GENE-991110-16|UniProtKB=Q9PUC4	Proteasome activator subunit 2	IDA	18859281	gi	PTHR10660:SF6	PROTEASOME ACTIVATOR COMPLEX SUBUNIT 2
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MOUSE|MGI=MGI=1351342|UniProtKB=Q3UVX5	Metabotropic glutamate receptor 5	ISS	9407094	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P02779	Thiamin biosynthesis	P03173	Thiamin phosphate synthase	STRCO|EnsemblGenome=CAB52013|UniProtKB=Q9S2V2	Thiamine-phosphate synthase	ISS			PTHR20857:SF15	THIAMINE BIOSYNTHETIC BIFUNCTIONAL ENZYME
P02751	Lysine biosynthesis	P03009	Aspartokinase	RHOBA|EnsemblGenome=RB8926|UniProtKB=Q7UMB6	Probable aspartokinase	ISS			PTHR21499:SF3	ASPARTOKINASE
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	CAEBR|Gene=CBG18000|UniProtKB=A8XSS7	Protein CBR-ACY-1	ISS	22013858	PubMed	PTHR11920:SF319	ADENYLATE CYCLASE TYPE 9
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	MACMU|Ensembl=ENSMMUG00000010743|UniProtKB=F7G171	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF76	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5
P02770	Pyridoxal phosphate salvage pathway	P03121	Pyridoxal kinase	TRYB2|Gene=Tb927.6.2740|UniProtKB=D6XI07	Pyridoxal kinase	ISS	9274862	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P00009	Axon guidance mediated by netrin	P00366	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00034	Integrin signalling pathway	P00916	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00048	PI3 kinase pathway	P01177	P110ACT	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	9094314	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00053	T cell activation	P01322	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00047	PDGF signaling pathway	P01151	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02749	Leucine biosynthesis	P03000	Branched chain amino acid aminotransferase	PANTR|Ensembl=ENSPTRG00000004772|UniProtKB=H2Q5L8	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF51	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, CYTOSOLIC
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04373	5HT1 type receptor mediated signaling pathway	P04409	5HT transporter	HUMAN|HGNC=11050|UniProtKB=P31645	Sodium-dependent serotonin transporter	IEA	7681602	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00047	PDGF signaling pathway	P01154	Ras	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	ISS	22097630	PubMed	PTHR24070:SF189	GTPASE NRAS
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	NEUCR|Gene=NCU01440|UniProtKB=V5INB2	Myosin-2	IC	22028976	PubMed	PTHR13140:SF725	DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	LEPIN|EnsemblGenome=LA_1929|UniProtKB=Q8CXT1	CAP family transcription factor	IC	2372396	PubMed	PTHR45452:SF1	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CHICK|Ensembl=ENSGALG00000015434|UniProtKB=F1NU20	Uncharacterized protein	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	CANLF|Ensembl=ENSCAFG00000030049|UniProtKB=J9NWQ5	Uncharacterized protein	ISS			PTHR23050:SF311	CALMODULIN
P00057	Wnt signaling pathway	P01428	Frizzled	HUMAN|HGNC=4039|UniProtKB=Q9ULW2	Frizzled-10	IDA	11212302	PubMed	PTHR11309:SF86	FRIZZLED-10
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00029	Huntington disease	P00796	Kainate receptor	ORNAN|Ensembl=ENSOANG00000010302|UniProtKB=F6TDQ6	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	XENTR|Xenbase=XB-GENE-854877|UniProtKB=F7C949	Presenilin	ISS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00053	T cell activation	P01315	Calcineurin	MACMU|Ensembl=ENSMMUG00000014442|UniProtKB=F7BBG8	Serine/threonine-protein phosphatase	ISS	12015605	PubMed	PTHR11668:SF186	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT GAMMA ISOFORM
P05916	Opioid prodynorphin pathway	P06002	G-protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00036	Interleukin signaling pathway	P00983	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	TAS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=98953|UniProtKB=P04426	Proto-oncogene Wnt-1	IDA	14644163	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00053	T cell activation	P01312	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00810	GAPDH	SCHPO|PomBase=SPBC32F12.11|UniProtKB=P78958	Glyceraldehyde-3-phosphate dehydrogenase 1	IPI			PTHR10836:SF52	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	HUMAN|HGNC=129|UniProtKB=P68133	Actin, alpha skeletal muscle	IC	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ORNAN|Ensembl=ENSOANG00000007581|UniProtKB=F6QWB7	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00018	EGF receptor signaling pathway	P00547	PP2A	XENTR|Xenbase=XB-GENE-957526|UniProtKB=K9J7P6	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P05730	Endogenous cannabinoid signaling	P05746	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	MOUSE|MGI=MGI=88495|UniProtKB=P27699	cAMP-responsive element modulator	ISS			PTHR22952:SF97	CAMP-RESPONSIVE ELEMENT MODULATOR
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	ISS			PTHR10048:SF14	PI-3 KINASE
P00048	PI3 kinase pathway	P01178	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	10521483	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	CHICK|Ensembl=ENSGALG00000009640|UniProtKB=F1P0I0	Muscarinic acetylcholine receptor	TAS	11166329	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	BOVIN|Ensembl=ENSBTAG00000010191|UniProtKB=Q08E52	Serine/threonine-protein kinase PAK 1	ISS	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00018	EGF receptor signaling pathway	P00552	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00005	Angiogenesis	P00236	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00782	alpha-Adaptin	CAEEL|WormBase=WBGene00000161|UniProtKB=Q22601	AdaPtin, Alpha chain (Clathrin associated complex)	IDA	11532990	PubMed	PTHR22780:SF4	AP-2 COMPLEX SUBUNIT ALPHA-2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	IC	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	HUMAN|HGNC=3176|UniProtKB=P05305	Endothelin-1	IEP	15117818	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P00055	Transcription regulation by bZIP transcription factor	P01392	TFIIH complex	HUMAN|HGNC=4657|UniProtKB=Q13889	General transcription factor IIH subunit 3	ISS			PTHR12831:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	CHICK|Ensembl=ENSGALG00000016226|UniProtKB=E1BWL4	Uncharacterized protein	ISS	11430913	PubMed	PTHR23122:SF40	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	10395542	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00020	FAS signaling pathway	P00604	Pro-Caspase8	CHICK|Ensembl=ENSGALG00000008355|UniProtKB=F1NXP6	Uncharacterized protein	IGI	11788820	PubMed	PTHR10454:SF162	CASPASE-8
P00019	Endothelin signaling pathway	P00582	COX-2	DANRE|ZFIN=ZDB-GENE-041014-323|UniProtKB=Q5RI06	Prostaglandin G/H synthase 2b	ISS			PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	DROME|FlyBase=FBgn0010051|UniProtKB=P29993	Inositol 1,4,5-trisphosphate receptor	ISS	9065779	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00036	Interleukin signaling pathway	P00964	p90RSK	CANLF|Ensembl=ENSCAFG00000013171|UniProtKB=E2RP04	Uncharacterized protein	ISS	10558991	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00005	Angiogenesis	P00181	SHP2	CHICK|Ensembl=ENSGALG00000004821|UniProtKB=Q90687	Tyrosine-protein phosphatase non-receptor type 11	ISS	8096088	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	SCHMA|EnsemblGenome=Smp_020170|UniProtKB=G4V8E3	Voltage-dependent calcium channel (Fragment)	ISS	14507926	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	DANRE|ZFIN=ZDB-GENE-040426-877|UniProtKB=F1Q6Z7	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01026	KA	CHICK|Ensembl=ENSGALG00000006638|UniProtKB=R4GGL9	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00470	F-actin	DICPU|Gene=DICPUDRAFT_48914|UniProtKB=F0ZK40	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF154	ACTIN-17-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	CANLF|Ensembl=ENSCAFG00000014601|UniProtKB=E2RFB9	Uncharacterized protein	ISS			PTHR10221:SF12	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	RCA	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02721	ATP synthesis	P02798	Cyt C	ORNAN|Ensembl=ENSOANG00000009156|UniProtKB=F7EJM9	Uncharacterized protein	ISS	5846985	PubMed	PTHR11961:SF12	CYTOCHROME C
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00052	TGF-beta signaling pathway	P01275	P38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	TAS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00049	Parkinson disease	P01242	Casein kinase I	RAT|RGD=621407|UniProtKB=Q62762	Casein kinase I isoform gamma-2	IDA	10617630	PubMed	PTHR11909:SF157	CASEIN KINASE I ISOFORM GAMMA-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02920	dCTP deaminase	DICDI|dictyBase=DDB_G0293580|UniProtKB=Q54BK9	dCTP deaminase	RCA			PTHR42680:SF3	DCTP DEAMINASE
P00015	Circadian clock system	G01500	bmal1	DROME|FlyBase=FBgn0023094|UniProtKB=O61734	Protein cycle	IDA	9630224	PubMed	PTHR23042:SF99	PROTEIN CYCLE
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01324	rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	10891487	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	89107990	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00034	Integrin signalling pathway	P00907	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02727	Androgen/estrogene/progesterone biosynthesis	P02826	Estradiol 17beta-dehydrogenase	RAT|RGD=2837|UniProtKB=Q62904	3-keto-steroid reductase	RCA			PTHR44442:SF1	3-KETO-STEROID REDUCTASE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9836512	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00260	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00052	TGF-beta signaling pathway	P01275	P38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	TAS	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00052	TGF-beta signaling pathway	P01286	TGFbeta	CHICK|Ensembl=ENSGALG00000007668|UniProtKB=F1NUT2	Uncharacterized protein	TAS	9759503	PubMed	PTHR11848:SF135	BONE MORPHOGENETIC PROTEIN 7
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	HUMAN|HGNC=6694|UniProtKB=P98164	Low-density lipoprotein receptor-related protein 2	IDA	11907044	PubMed	PTHR44025:SF5	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2
P00034	Integrin signalling pathway	P00951	Jnk	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00047	PDGF signaling pathway	P01143	ERK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00048	PI3 kinase pathway	P01198	FOXO	PANTR|Ensembl=ENSPTRG00000022004|UniProtKB=H2RDV7	Uncharacterized protein	ISS			PTHR11829:SF188	FORKHEAD BOX PROTEIN O4
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IDA	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00906	Rap1	DANRE|ZFIN=ZDB-GENE-090312-116|UniProtKB=B8JIV0	Uncharacterized protein	ISS	8576107	PubMed	PTHR24070:SF221	RAS-RELATED PROTEIN RAP-2A
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P06664	Gonadotropin-releasing hormone receptor pathway	P06861	MAP4Ks	MOUSE|MGI=MGI=2154405|UniProtKB=Q99JP0	Mitogen-activated protein kinase kinase kinase kinase 3	RCA			PTHR24361:SF205	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	7492337	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00007	Axon guidance mediated by semaphorins	P00337	Sema3A	MOUSE|MGI=MGI=107558|UniProtKB=O08665	Semaphorin-3A	ISS			PTHR11036:SF23	SEMAPHORIN-3A
P00019	Endothelin signaling pathway	P00575	furin	HUMAN|HGNC=8568|UniProtKB=P09958	Furin	ISS	11861638	PubMed	PTHR42884:SF1	FURIN
P00056	VEGF signaling pathway	P01414	PLC-gamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00897	SHIP2	MACMU|Ensembl=ENSMMUG00000010451|UniProtKB=F7CRA7	Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2	ISS	10381377	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00059	p53 pathway	P04630	PP2A	MACMU|Ensembl=ENSMMUG00000020819|UniProtKB=F7HSM1	Serine/threonine-protein phosphatase	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04393	Ras Pathway	P04570	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DROME|FlyBase=FBgn0004623|UniProtKB=P29829	Guanine nucleotide-binding protein subunit beta-2	IC			PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00010	B cell activation	P00371	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00402	Jnk	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IDA	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IDA	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00057	Wnt signaling pathway	P01429	Axin	CANLF|Ensembl=ENSCAFG00000011236|UniProtKB=E2R9F8	Uncharacterized protein	ISS	12356903	PubMed	PTHR10845:SF103	AXIN-2
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	BOVIN|Ensembl=ENSBTAG00000007909|UniProtKB=F1MPE9	Uncharacterized protein	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	CANLF|Ensembl=ENSCAFG00000005526|UniProtKB=E2RKR0	Uncharacterized protein	ISS	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00056	VEGF signaling pathway	P01407	Erk	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00200	Dsh	CANLF|Ensembl=ENSCAFG00000019275|UniProtKB=E2QY91	Uncharacterized protein	ISS	11212302	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT4G36450|UniProtKB=O23236	Mitogen-activated protein kinase 14	ISS	12787066	PubMed	PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	HUMAN|HGNC=7778|UniProtKB=Q14934	Nuclear factor of activated T-cells, cytoplasmic 4	ISS	9133421	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00047	PDGF signaling pathway	P01161	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00059	p53 pathway	G04694	p110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	XENTR|Xenbase=XB-GENE-963560|UniProtKB=Q0VFC4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00019	Endothelin signaling pathway	P00572	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00048	PI3 kinase pathway	P01182	Ras	CAEEL|WormBase=WBGene00002335|UniProtKB=P22981	Ras protein let-60	ISS	22022015	PubMed	PTHR24070:SF385	GTPASE HRAS
P00038	JAK/STAT signaling pathway	P01027	STAT	CANLF|Ensembl=ENSCAFG00000015509|UniProtKB=F1PNW8	Signal transducer and activator of transcription	ISS	10835485	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00059	p53 pathway	P04612	HDAC1	MOUSE|MGI=MGI=108086|UniProtKB=O09106	Histone deacetylase 1	IDA	10485845	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P00021	FGF signaling pathway	P00638	PLCgamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	RAT|RGD=69319|UniProtKB=P54313	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CHICK|Ensembl=ENSGALG00000000168|UniProtKB=P49892	Adenosine receptor A1	IDA	11781138	PubMed	PTHR24246:SF1	ADENOSINE RECEPTOR A1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MOUSE|MGI=MGI=95818|UniProtKB=Q61626	Glutamate receptor ionotropic, kainate 5	ISS	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IDA	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00034	Integrin signalling pathway	P00912	Arp2/3	ORNAN|Ensembl=ENSOANG00000000999|UniProtKB=F6WN02	Actin-related protein 2/3 complex subunit 5	ISS	10322212	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8668|UniProtKB=Q9Y5H9	Protocadherin alpha-2	IDA	8120095	PubMed	PTHR24028:SF60	PROTOCADHERIN ALPHA-2
P04395	Vasopressin synthesis	P04590	Vasopressin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00052	TGF-beta signaling pathway	P01284	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02747	Histidine biosynthesis	P02986	Phosphoribosyl ATP pyrophosphatase	GLOVI|EnsemblGenome=BAC89152|UniProtKB=Q7NLB5	Histidine biosynthesis bifunctional protein HisIE	ISS			PTHR42945:SF1	HISTIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN HISIE, CHLOROPLASTIC
P00021	FGF signaling pathway	P00624	14-3-3	CANLF|Ensembl=ENSCAFG00000031015|UniProtKB=J9P6N4	Uncharacterized protein	ISS	14593000	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00049	Parkinson disease	P01227	20S proteasome	CAEBR|Gene=CBG09700|UniProtKB=A8X8G7	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF16	PROTEASOME SUBUNIT ALPHA TYPE-2
P00018	EGF receptor signaling pathway	G01511	SPRY	HUMAN|HGNC=11270|UniProtKB=O43597	Protein sprouty homolog 2	IGI	12402043	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P00059	p53 pathway	P01486	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02746	Heme biosynthesis	P02974	Uroporphyrinogen-III synthase	DANRE|ZFIN=ZDB-GENE-040323-2|UniProtKB=Q800W7	Uncharacterized protein	ISS			PTHR12390:SF0	UROPORPHYRINOGEN-III SYNTHASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00005	Angiogenesis	P00248	Ang-1	DANRE|ZFIN=ZDB-GENE-010817-1|UniProtKB=Q1MT43	Uncharacterized protein	ISS			PTHR19143:SF156	ANGIOPOIETIN-1
P04393	Ras Pathway	P04543	MEKK1/4	CANLF|Ensembl=ENSCAFG00000000760|UniProtKB=E2R9L4	Uncharacterized protein	ISS	12052864	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	ISS	15860573	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00632	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00023	General transcription regulation	P00658	TBP-associated factors	RAT|RGD=1308423|UniProtKB=D3ZY89	Protein Taf8	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00036	Interleukin signaling pathway	P00975	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=8153|UniProtKB=P41143	Delta-type opioid receptor	IDA	11259498	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00005	Angiogenesis	P00256	PLC-gamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00019	Endothelin signaling pathway	P00566	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	21150461	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1693|UniProtKB=Q6P967	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00059	p53 pathway	P04633	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00020	FAS signaling pathway	P00601	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00034	Integrin signalling pathway	P00912	Arp2/3	HUMAN|HGNC=23366|UniProtKB=Q9BPX5	Actin-related protein 2/3 complex subunit 5-like protein	IPI	12473693	PubMed	PTHR12644:SF2	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5-LIKE PROTEIN
P00011	Blood coagulation	P00403	EPCR	BOVIN|Ensembl=ENSBTAG00000008291|UniProtKB=Q28105	Endothelial protein C receptor	ISS	13626538	gi	PTHR15349:SF0	ENDOTHELIAL PROTEIN C RECEPTOR
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	LEIMA|EnsemblGenome=LmjF.18.1080|UniProtKB=Q27687	Protein kinase A catalytic subunit	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00049	Parkinson disease	P01230	Src kinase	DANRE|ZFIN=ZDB-GENE-050706-89|UniProtKB=F1RDG9	Tyrosine-protein kinase fynb	ISS	11162638	PubMed	PTHR24418:SF242	TYROSINE-PROTEIN KINASE FYNB
P00004	Alzheimer disease-presenilin pathway	P00165	E-cadherin N-terminal fragment	MACMU|Ensembl=ENSMMUG00000010393|UniProtKB=F7D992	Uncharacterized protein	ISS	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00012	Cadherin signaling pathway	P00474	Wnt	BOVIN|Ensembl=ENSBTAG00000020221|UniProtKB=E1BDG5	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00052	TGF-beta signaling pathway	P01292	RSmads	CHICK|Ensembl=ENSGALG00000006309|UniProtKB=Q56I99	Mothers against decapentaplegic homolog 5	ISS	12736218	PubMed	PTHR13703:SF36	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=14265|UniProtKB=Q86UP0	Cadherin-24	IDA	8120095	PubMed	PTHR24027:SF272	CADHERIN-24
P02740	De novo pyrimidine ribonucleotides biosythesis	P02928	Dihydroorotase	MYCTU|EnsemblGenome=Rv1381|UniProtKB=P9WHL3	Dihydroorotase	ISS			PTHR43668:SF1	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01423	p38MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00053	T cell activation	P01311	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	XENTR|Xenbase=XB-GENE-6067221|UniProtKB=F6Z0J4	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IDA	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00029	Huntington disease	P00774	Dynein complex	PANTR|Ensembl=ENSPTRG00000014721|UniProtKB=H2QM89	Dynein, cytoplasmic 1, light intermediate chain 1	ISS	9454836	PubMed	PTHR12688:SF2	CYTOPLASMIC DYNEIN 1 LIGHT INTERMEDIATE CHAIN 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06847	JNK1/2	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	RCA	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00008	Axon guidance mediated by Slit/Robo	P00342	Slit	RAT|RGD=69307|UniProtKB=O88279	Slit homolog 1 protein	ISS	10432110	PubMed	PTHR24373:SF39	SLIT HOMOLOG 1 PROTEIN
P00034	Integrin signalling pathway	P00924	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ORYSJ|EnsemblGenome=OS06G0699400|UniProtKB=Q5Z859	Mitogen-activated protein kinase 4	ISS	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IPI	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	CANLF|Ensembl=ENSCAFG00000011733|UniProtKB=E2R5J6	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00260	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MOUSE|MGI=MGI=894644|UniProtKB=Q8CC27	Voltage-dependent L-type calcium channel subunit beta-2	IC	20088160	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00797	p53	DANRE|ZFIN=ZDB-GENE-030819-1|UniProtKB=E9QG65	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PANTR|Ensembl=ENSPTRG00000011990|UniProtKB=H2QHZ9	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000032222|UniProtKB=F7FW05	Uncharacterized protein	ISS	12181435	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00310	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IDA	10799299	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05918	p38 MAPK pathway	P06044	GADD45	MACMU|Ensembl=ENSMMUG00000014808|UniProtKB=F6W540	Growth arrest and DNA damage-inducible protein GADD45 alpha isoform 1	ISS	10097101	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00029	Huntington disease	P00810	GAPDH	DEIRA|EnsemblGenome=DR_1343|UniProtKB=Q9RUP1	Glyceraldehyde-3-phosphate dehydrogenase	IPI			PTHR43148:SF2	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE C-RELATED
P00034	Integrin signalling pathway	P00925	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00019	Endothelin signaling pathway	P00572	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00898	FKHR	RAT|RGD=620283|UniProtKB=G3V7R4	Forkhead box protein O1	TAS			PTHR11829:SF159	FORKHEAD BOX PROTEIN O1
P00008	Axon guidance mediated by Slit/Robo	P00348	Robo	HUMAN|HGNC=10249|UniProtKB=Q9Y6N7	Roundabout homolog 1	ISS			PTHR44096:SF1	ROUNDABOUT HOMOLOG 1
P00005	Angiogenesis	P00211	GSK3beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00034	Integrin signalling pathway	P00948	Rho	DAPPU|EnsemblGenome=DAPPUDRAFT_301996|UniProtKB=E9HL06	Putative uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00011	Blood coagulation	P00458	GP IIIa	MACMU|Ensembl=ENSMMUG00000003289|UniProtKB=F7FG54	Integrin beta	ISS	5805343	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	21157398	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	CANLF|Ensembl=ENSCAFG00000006059|UniProtKB=F1Q126	Uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00007	Axon guidance mediated by semaphorins	P00330	CRAM	CANLF|Ensembl=ENSCAFG00000023265|UniProtKB=F1PK01	Uncharacterized protein	ISS	10851247	PubMed	PTHR11647:SF58	DIHYDROPYRIMIDINASE-RELATED PROTEIN 5
P00049	Parkinson disease	P01238	14-3-3	BOVIN|Gene=YWHAG|UniProtKB=P68252	14-3-3 protein gamma	ISS	10407019	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00560	Raf-1	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	ISS			PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P02787	Vitamin B6 metabolism	P03227	Phosphoserine transaminase	ECOLI|EcoGene=EG10946|UniProtKB=P23721	Phosphoserine aminotransferase	ISS	11206551	PubMed	PTHR43247:SF2	PHOSPHOSERINE AMINOTRANSFERASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	RCA	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00034	Integrin signalling pathway	P00907	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	TAS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	RAT|RGD=2246|UniProtKB=Q07652	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	14507926	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PRIPA|Gene=PPA17339|UniProtKB=H3F5B4	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF352	ACTIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00709	Glycogen synthase D	HUMAN|HGNC=4707|UniProtKB=P54840	Glycogen [starch] synthase, liver	IDA	4212312	PubMed	PTHR10176:SF1	GLYCOGEN  STARCH  SYNTHASE, LIVER
P00012	Cadherin signaling pathway	P00475	Frizzled	DANRE|ZFIN=ZDB-GENE-990415-229|UniProtKB=Q8QFM3	Frizzled 7a	IDA	11212302	PubMed	PTHR11309:SF31	FRIZZLED-7
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	ORNAN|Ensembl=ENSOANG00000006060|UniProtKB=F6PNT9	Integrin beta	ISS	10706722	PubMed	PTHR10082:SF28	INTEGRIN BETA-1
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00807	Actin	BOVIN|Ensembl=ENSBTAG00000006189|UniProtKB=P63258	Actin, cytoplasmic 2	ISS	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04396	Vitamin D metabolism and pathway	P04605	P450 reductase	BOVIN|Gene=POR|UniProtKB=Q3SYT8	NADPH--cytochrome P450 reductase	ISS	2513880	PubMed	PTHR19384:SF17	NADPH--CYTOCHROME P450 REDUCTASE
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MOUSE|MGI=MGI=95821|UniProtKB=Q01097	Glutamate receptor ionotropic, NMDA 2B	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	RAT|RGD=2746|UniProtKB=P31424	Metabotropic glutamate receptor 5	IDA	12488551	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00011	Blood coagulation	P00414	Thrombin	HUMAN|HGNC=3535|UniProtKB=P00734	Prothrombin	IC	4503635	gi	PTHR24254:SF10	PROTHROMBIN
P00005	Angiogenesis	P00253	Axin	RAT|RGD=620859|UniProtKB=O70239	Axin-1	ISS	12356903	PubMed	PTHR10845:SF11	AXIN-1
P02738	De novo purine biosynthesis	P02907	dADP kinase	HUMAN|HGNC=7850|UniProtKB=P22392	Nucleoside diphosphate kinase B	ISS			PTHR11349:SF57	NUCLEOSIDE DIPHOSPHATE KINASE B
P00053	T cell activation	P01307	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04371	5-Hydroxytryptamine biosynthesis	P04399	Tryptophan hydroxylase	CAEBR|Gene=CBG12991|UniProtKB=A8XGU6	Protein CBR-TPH-1	ISS	14597720	PubMed	PTHR11473:SF16	TRYPTOPHAN 5-HYDROXYLASE 2
P00005	Angiogenesis	P00220	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00012	Cadherin signaling pathway	P00475	Frizzled	MACMU|Ensembl=ENSMMUG00000022114|UniProtKB=F7H7V5	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF81	FRIZZLED-1
P00011	Blood coagulation	P00454	FVII	HUMAN|HGNC=3544|UniProtKB=P08709	Coagulation factor VII	ISS	11487022	PubMed	PTHR44064:SF1	COAGULATION FACTOR VII
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_56698|UniProtKB=C3XYC3	Putative uncharacterized protein	IDA	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	MACMU|Ensembl=ENSMMUG00000010987|UniProtKB=F7GCX9	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P06959	CCKR signaling map	P07215	G17	HUMAN|HGNC=4164|UniProtKB=P01350	Gastrin	RCA	21156802	PubMed	PTHR19309:SF0	GASTRIN
P00021	FGF signaling pathway	P00647	SHP2	PANTR|Ensembl=ENSPTRG00000042397|UniProtKB=H2RIH8	Tyrosine-protein phosphatase non-receptor type	ISS	95163101	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00049	Parkinson disease	P01211	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P06211	BMP/activin signaling pathway-drosophila	P06251	BMP/activin orthologous ligand	DROME|FlyBase=FBgn0031461|UniProtKB=Q9VQG9	Dawdle, isoform A	RCA	12537572	PubMed	PTHR11848:SF226	DAWDLE, ISOFORM A
P00057	Wnt signaling pathway	P01437	TCF	MONDO|Ensembl=ENSMODG00000020603|UniProtKB=F6ZBJ4	Uncharacterized protein	ISS	11266476	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00048	PI3 kinase pathway	P01192	p110	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	STRPU|EnsemblGenome=SPU_017814|UniProtKB=W4YPT6	Uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF263	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04572	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00010	B cell activation	P00398	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P02741	Flavin biosynthesis	P02935	GTP cyclohydrolase	NEUCR|EnsemblGenome=EFNCRG00000007253|UniProtKB=Q1K5V5	GTP cyclohydrolase-2	ISS			PTHR21327:SF13	GTP CYCLOHYDROLASE-2
P00053	T cell activation	P01333	cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00201	FVIIa	BOVIN|Ensembl=ENSBTAG00000007411|UniProtKB=P22457	Coagulation factor VII	ISS	119765	gi	PTHR44064:SF1	COAGULATION FACTOR VII
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P06959	CCKR signaling map	P07168	p66 SHC1	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	RCA	8760305	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00010	B cell activation	P00398	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	HUMAN|HGNC=1606|UniProtKB=P51681	C-C chemokine receptor type 5	ISS			PTHR10489:SF686	C-C CHEMOKINE RECEPTOR TYPE 5
P00018	EGF receptor signaling pathway	P00558	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IGI	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	ORYSJ|EnsemblGenome=OS03G0712800|UniProtKB=Q4W8D0	Glutamine synthetase cytosolic isozyme 1-3	ISS			PTHR20852:SF58	GLUTAMINE SYNTHETASE CYTOSOLIC ISOZYME 1-2
P00047	PDGF signaling pathway	P01153	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00015	Circadian clock system	G01501	cry	PANTR|Ensembl=ENSPTRG00000003537|UniProtKB=H2Q3H0	Uncharacterized protein	ISS	10428031	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	HUMAN|HGNC=1951|UniProtKB=P08172	Muscarinic acetylcholine receptor M2	TAS	91373358	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00015	Circadian clock system	G01504	bmal1	CANLF|Ensembl=ENSCAFG00000008095|UniProtKB=J9NTT7	Uncharacterized protein	ISS	11163178	PubMed	PTHR23042:SF52	ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 1
P00010	B cell activation	P00384	p38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	IDA	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IDA	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00007	Axon guidance mediated by semaphorins	P00340	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12874273	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01015	Glu4	MOUSE|MGI=MGI=95811|UniProtKB=Q9Z2W8	Glutamate receptor 4	ISS	12941441	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00005	Angiogenesis	P00203	Erk	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	RAT|RGD=1310508|UniProtKB=D4AEP0	Adenylosuccinate synthetase isozyme 2	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00049	Parkinson disease	P01219	SAPK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	NAS	12040174	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IDA	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00053	T cell activation	P01311	Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	IDA	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00017	DNA replication	P00529	RFC	HUMAN|HGNC=9970|UniProtKB=P35250	Replication factor C subunit 2	RCA			PTHR11669:SF5	REPLICATION FACTOR C SUBUNIT 2
P00048	PI3 kinase pathway	P01188	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	MOUSE|MGI=MGI=1351344|UniProtKB=Q68ED2	Metabotropic glutamate receptor 7	ISS	11431030	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00048	PI3 kinase pathway	P01196	PDK1	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	IGI	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P02738	De novo purine biosynthesis	P02892	5-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase	SCHMA|EnsemblGenome=Smp_038030|UniProtKB=G4VQX9	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02723	Adenine and hypoxanthine salvage pathway	P02804	Hypoxanthine phosphoribosyl transferase	CHICK|Gene=HPRT1|UniProtKB=Q9W719	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF6	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE
P00036	Interleukin signaling pathway	P00990	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	HUMAN|HGNC=4583|UniProtKB=Q16478	Glutamate receptor ionotropic, kainate 5	ISS	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00049	Parkinson disease	P01242	Casein kinase I	MACMU|Ensembl=ENSMMUG00000006620|UniProtKB=F7H481	Uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF157	CASEIN KINASE I ISOFORM GAMMA-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00005	Angiogenesis	P00194	Paxillin	DICDI|dictyBase=DDB_G0284863|UniProtKB=Q54NW4	LIM domain-containing protein B	ISS			PTHR24216:SF32	LIM DOMAIN-CONTAINING PROTEIN B
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00056	VEGF signaling pathway	P01408	Akt/PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	DANRE|ZFIN=ZDB-GENE-010705-1|UniProtKB=Q90Z40	Guanine nucleotide-binding protein subunit gamma	IC	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00059	p53 pathway	P04623	CBP	HUMAN|HGNC=3373|UniProtKB=Q09472	Histone acetyltransferase p300	IDA	8413673	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00021	FGF signaling pathway	P00638	PLCgamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00017	DNA replication	P00527	Histones	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g148952|UniProtKB=A7T7J5	Histone H3 (Fragment)	ISS	12413958	PubMed	PTHR11426:SF171	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00223	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00056	VEGF signaling pathway	P01408	Akt/PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01411	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	3035212	PubMed	PTHR24070:SF385	GTPASE HRAS
P00049	Parkinson disease	P01208	Hsp70	YEAST|SGD=S000000004|UniProtKB=P10591	Heat shock protein SSA1	IDA	12150907	PubMed	PTHR19375:SF309	HEAT SHOCK PROTEIN SSA1-RELATED
P04397	p53 pathway by glucose deprivation	P04641	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1203729|UniProtKB=Q61194	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00575	furin	PANTR|Ensembl=ENSPTRG00000007461|UniProtKB=H2QA34	Furin (Paired basic amino acid cleaving enzyme)	ISS	95328031	PubMed	PTHR42884:SF1	FURIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MACMU|Ensembl=ENSMMUG00000006253|UniProtKB=F7H582	Uncharacterized protein	ISS	10978539	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00587	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00256	PLC-gamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CAEBR|Gene=CBG05858|UniProtKB=A8X1H0	Protein CBR-EGL-19 (Fragment)	ISS	15737619	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04398	p53 pathway feedback loops 2	G04709	MDM-2	DANRE|ZFIN=ZDB-GENE-990415-153|UniProtKB=O42354	E3 ubiquitin-protein ligase Mdm2	IGI	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00029	Huntington disease	P00778	NMDA receptor	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	IDA	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00057	Wnt signaling pathway	P01458	Protein Kinase C	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00047	PDGF signaling pathway	P01153	GSK3	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	PANTR|Ensembl=ENSPTRG00000006175|UniProtKB=H2R2N7	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF721	MYOSIN-6
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00010	B cell activation	P00369	MEKK	MACMU|Ensembl=ENSMMUG00000016751|UniProtKB=F7AIB6	Mitogen-activated protein kinase kinase kinase 3 isoform 1	ISS	9006902	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00623	FGF	PANTR|Ensembl=ENSPTRG00000020046|UniProtKB=H2R1J0	Fibroblast growth factor	ISS	9514906	PubMed	PTHR11486:SF71	FIBROBLAST GROWTH FACTOR 17
P00049	Parkinson disease	P01236	Casein kinase II	DROME|FlyBase=FBgn0000259|UniProtKB=P08182	Casein kinase II subunit beta	IDA	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00012	Cadherin signaling pathway	P00470	F-actin	XENTR|Xenbase=XB-GENE-493937|UniProtKB=Q5M8T9	Actin, alpha 2, smooth muscle, aorta	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00052	TGF-beta signaling pathway	P01275	P38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	TAS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00580	ET-RA/B	MACMU|Ensembl=ENSMMUG00000003659|UniProtKB=F7HSF3	Endothelin-1 receptor isoform a	ISS	12538737	PubMed	PTHR24243:SF31	ENDOTHELIN-1 RECEPTOR
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00384	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	12810719	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00029	Huntington disease	P00796	Kainate receptor	HUMAN|HGNC=4581|UniProtKB=Q13003	Glutamate receptor ionotropic, kainate 3	IDA	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	BRAFL|Gene=BRAFLDRAFT_283143|UniProtKB=C3Y645	Putative uncharacterized protein	ISS			PTHR23431:SF3	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00012	Cadherin signaling pathway	P00474	Wnt	DANRE|ZFIN=ZDB-GENE-980526-524|UniProtKB=Q801F7	Protein Wnt-10b	ISS	8717036	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00049	Parkinson disease	P01242	Casein kinase I	ARATH|TAIR=AT5G44100|UniProtKB=Q9FFH8	At5g44100	IDA	10617630	PubMed	PTHR11909:SF114	ADK1-RELATED
P05913	Enkephalin release	P05972	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00036	Interleukin signaling pathway	P00968	Ikk	PANTR|Ensembl=ENSPTRG00000020202|UniProtKB=H2QW34	Uncharacterized protein	ISS	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05917	Opioid proopiomelanocortin pathway	P06010	proopiomelanocortin	DANRE|ZFIN=ZDB-GENE-041014-294|UniProtKB=Q5SPP4	Uncharacterized protein	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00047	PDGF signaling pathway	P01143	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	HUMAN|HGNC=12726|UniProtKB=P04275	von Willebrand factor	TAS	193400	OMIM	PTHR11339:SF361	VON WILLEBRAND FACTOR-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00892	Grb2	CAEBR|Gene=CBG16856|UniProtKB=A8XPY6	Protein CBR-SEM-5	ISS	4504111	gi	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P05913	Enkephalin release	P05972	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00551	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	STRPU|EnsemblGenome=SPU_006797|UniProtKB=W4XTP5	Uncharacterized protein	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	HUMAN|HGNC=21285|UniProtKB=Q96PN6	Adenylate cyclase type 10	IGI	11744988	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00520	Rho GAPs	CAEEL|WormBase=WBGene00012203|UniProtKB=Q23130	Rho GTPase Activating protein	ISS			PTHR23176:SF0	RHO GTPASE-ACTIVATING PROTEIN 68F
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00011	Blood coagulation	P00433	uPAR	HUMAN|HGNC=9053|UniProtKB=Q03405	Urokinase plasminogen activator surface receptor	ISS	11875695	gi	PTHR10624:SF6	UROKINASE PLASMINOGEN ACTIVATOR SURFACE RECEPTOR
P00030	Hypoxia response via HIF activation	P00825	Thioredoxin	METAC|EnsemblGenome=MA_3212|UniProtKB=Q8TL30	Thioredoxin	ISS			PTHR10438:SF358	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04559	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	HUMAN|HGNC=7574|UniProtKB=Q9Y623	Myosin-4	IEP	10938134	PubMed	PTHR13140:SF681	MYOSIN-4
P00034	Integrin signalling pathway	P00931	Integrin beta	BOVIN|Ensembl=ENSBTAG00000017060|UniProtKB=P32592	Integrin beta-2	IDA	3487386	PubMed	PTHR10082:SF15	INTEGRIN BETA-2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00036	Interleukin signaling pathway	P00973	PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01443	Phospholipase C	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00034	Integrin signalling pathway	P00922	Collagen	PANTR|Ensembl=ENSPTRG00000014012|UniProtKB=H2QL57	Uncharacterized protein	ISS	10727440	PubMed	PTHR44172:SF3	COLLAGEN ALPHA-1 VI  CHAIN
P06664	Gonadotropin-releasing hormone receptor pathway	P06798	PKCe/theta	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	RCA	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00644	p38	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	IGI	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MACMU|Ensembl=ENSMMUG00000003405|UniProtKB=F7FE85	Uncharacterized protein	ISS	12356903	PubMed	PTHR10201:SF143	MATRILYSIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	ANOGA|EnsemblGenome=AGAP002974|UniProtKB=Q7QD62	AGAP002974-PA	IC	85270494	PubMed	PTHR18945:SF592	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-LIKE 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=19218|UniProtKB=Q86YW0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1	ISS	12860966	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	ISS	8170357	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	BOVIN|Ensembl=ENSBTAG00000037985|UniProtKB=F1MCK3	Muscarinic acetylcholine receptor	ISS	8100450	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00034	Integrin signalling pathway	P00948	Rho	PANTR|Ensembl=ENSPTRG00000009235|UniProtKB=H2QD45	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF21	RHO-RELATED GTP-BINDING PROTEIN RHON
P00055	Transcription regulation by bZIP transcription factor	P01390	TFIIA complex	XENTR|Xenbase=XB-GENE-990822|UniProtKB=Q6DEQ4	Transcription initiation factor IIA subunit 2	ISS			PTHR10966:SF0	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00052	TGF-beta signaling pathway	P01290	TAB	MOUSE|MGI=MGI=1913763|UniProtKB=Q8CF89	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1	ISS	8638164	PubMed	PTHR13832:SF533	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	BOVIN|Ensembl=ENSBTAG00000024507|UniProtKB=E1BNF2	Uncharacterized protein	ISS	2433589	PubMed	PTHR11767:SF17	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 3
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04398	p53 pathway feedback loops 2	P04657	P110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00006	Apoptosis signaling pathway	P00274	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00053	T cell activation	P01309	fos	PANTR|Ensembl=ENSPTRG00000006553|UniProtKB=A5A6H0	C-fos	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	HUMAN|HGNC=6698|UniProtKB=O75581	Low-density lipoprotein receptor-related protein 6	IDA	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	PSEAE|EnsemblGenome=PA1156|UniProtKB=Q9I4I1	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	RCA	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	HUMAN|HGNC=1389|UniProtKB=Q00975	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	14624853	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IDA	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00049	Parkinson disease	P01226	CDCrel-1	MACMU|Ensembl=ENSMMUG00000008423|UniProtKB=F6VBY7	Septin-4 isoform 1	ISS			PTHR18884:SF71	SEPTIN-4
P02763	Peptidoglycan biosynthesis	P03091	D-alanine-D-alanine ligase	LEPIN|EnsemblGenome=LA_2058|UniProtKB=Q8F4I2	D-alanine--D-alanine ligase	ISS			PTHR23132:SF12	D-ALANINE--D-ALANINE LIGASE B
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	IC	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00053	T cell activation	P01315	Calcineurin	MOUSE|MGI=MGI=107163|UniProtKB=P48453	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	ISS	7532676	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	LEIMA|EnsemblGenome=LmjF.35.3960|UniProtKB=E9AFM1	Protein kinase A catalytic subunit isoform 2	ISS	14744463	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CAEEL|WormBase=WBGene00001133|UniProtKB=Q9U298	Neuronal acetylcholine receptor subunit eat-2	IC			PTHR18945:SF387	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT EAT-2
P00023	General transcription regulation	P00670	TBP	XENTR|Xenbase=XB-GENE-488460|UniProtKB=Q6DIY4	TATA box-binding protein-like protein 1	ISS	600075	OMIM	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P04397	p53 pathway by glucose deprivation	P04641	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00139	E-cadherin transmembrane fragment	PANTR|Ensembl=ENSPTRG00000008270|UniProtKB=H2QBE5	Uncharacterized protein	ISS	11953314	PubMed	PTHR24027:SF319	CADHERIN-1
P00018	EGF receptor signaling pathway	P00565	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	11554554	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00009	Axon guidance mediated by netrin	P00356	UNC-5	MONDO|Ensembl=ENSMODG00000019260|UniProtKB=F6Q8P2	Uncharacterized protein	ISS			PTHR12582:SF7	NETRIN RECEPTOR UNC5C
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	DANRE|ZFIN=ZDB-GENE-991119-4|UniProtKB=Q9W6T7	Presenilin-1	TAS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P04398	p53 pathway feedback loops 2	G04708	WIP-1	PANTR|Ensembl=ENSPTRG00000009487|UniProtKB=H2RBB5	Uncharacterized protein	ISS			PTHR13832:SF359	PROTEIN PHOSPHATASE 1D
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	BRAFL|Gene=BRAFLDRAFT_220697|UniProtKB=C3ZSF0	Putative uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00053	T cell activation	P01305	Calmodulin	DROME|FlyBase=FBgn0000253|UniProtKB=P62152	Calmodulin	ISS			PTHR23050:SF245	AT16150P-RELATED
P05913	Enkephalin release	P05975	GPCR (s)	HUMAN|HGNC=8156|UniProtKB=P35372	Mu-type opioid receptor	ISS	11259487	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00053	T cell activation	P01311	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	3449797	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00570	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05964	GNAZ	CHICK|Ensembl=ENSGALG00000006719|UniProtKB=F1NZY0	Uncharacterized protein	ISS	16814816	PubMed	PTHR10218:SF65	GUANINE NUCLEOTIDE-BINDING PROTEIN G Z  SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00470	F-actin	ORNAN|Ensembl=ENSOANG00000007716|UniProtKB=F6UDX9	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00053	T cell activation	P01307	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04393	Ras Pathway	P04542	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04494	TSC2	MOUSE|MGI=MGI=102548|UniProtKB=Q61037	Tuberin	IDA	15249583	PubMed	PTHR10063:SF0	TUBERIN
P00010	B cell activation	P00384	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05918	p38 MAPK pathway	P06020	p38delta	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	HUMAN|HGNC=4597|UniProtKB=P41594	Metabotropic glutamate receptor 5	ISS	8314195	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00053	T cell activation	P01330	IKK	RAT|RGD=1306661|UniProtKB=G3V926	Conserved helix-loop-helix ubiquitous kinase (Predicted)	ISS	12813046	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	IDA	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	LEIMA|EnsemblGenome=LmjF.35.4010|UniProtKB=Q9GNR4	Protein kinase A catalytic subunit isoform 1	IC	14744463	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00015	Circadian clock system	P00502	Casein kinase I	XENTR|Xenbase=XB-GENE-5733929|UniProtKB=Q6P647	Casein kinase I isoform delta	ISS	11437445	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MOUSE|MGI=MGI=95821|UniProtKB=Q01097	Glutamate receptor ionotropic, NMDA 2B	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00029	Huntington disease	P00763	Hip-12	RAT|RGD=621615|UniProtKB=F1LML7	Protein Hip1r	RCA			PTHR10407:SF10	HUNTINGTIN-INTERACTING PROTEIN 1-RELATED PROTEIN
P02757	O-antigen biosynthesis	P03045	dTDP-glucose 4,6-dehydratase	CAEBR|Gene=CBG14085|UniProtKB=A8XJB2	Protein CBG14085	ISS			PTHR43000:SF6	SUBFAMILY NOT NAMED
P00049	Parkinson disease	P01227	20S proteasome	CAEEL|WormBase=WBGene00003927|UniProtKB=O44156	Proteasome subunit alpha type-1	TAS	12859888	PubMed	PTHR11599:SF12	PROTEASOME SUBUNIT ALPHA TYPE-RELATED
P00059	p53 pathway	P04616	PDK1/2	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	TAS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00205	GAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	8270251	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P02736	Coenzyme A biosynthesis	P02883	Pantothenoylcysteine decarboxylase	FUSNN|EnsemblGenome=FN0711|UniProtKB=Q8RFI5	Phosphopantothenate--cysteine ligase	ISS			PTHR14359:SF6	PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P05731	GABA-B receptor II signaling	P05754	Ggamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	BOVIN|Ensembl=ENSBTAG00000013555|UniProtKB=F1MSQ2	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P00029	Huntington disease	P00770	N-CoR	CANLF|Ensembl=ENSCAFG00000018040|UniProtKB=E2RKW5	Uncharacterized protein	ISS	10441327	PubMed	PTHR13992:SF5	NUCLEAR RECEPTOR COREPRESSOR 1
P00029	Huntington disease	P00807	Actin	HUMAN|HGNC=143|UniProtKB=P68032	Actin, alpha cardiac muscle 1	IDA	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00025	Hedgehog signaling pathway	P00683	Slimb	MOUSE|MGI=MGI=1338871|UniProtKB=Q3ULA2	F-box/WD repeat-containing protein 1A	ISS	10074433	PubMed	PTHR44038:SF2	F-BOX/WD REPEAT-CONTAINING PROTEIN 1A
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	XENTR|Xenbase=XB-GENE-5774698|UniProtKB=F6STP6	Uncharacterized protein (Fragment)	ISS			PTHR10221:SF12	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6
P00021	FGF signaling pathway	P00640	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01319	PAK	CHICK|Ensembl=ENSGALG00000006426|UniProtKB=E1BS97	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CRYNJ|EnsemblGenome=CND03830|UniProtKB=Q5KI86	Uncharacterized protein	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	HUMAN|HGNC=21285|UniProtKB=Q96PN6	Adenylate cyclase type 10	IGI	10915626	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P04380	Cortocotropin releasing factor receptor signaling pathway	P04452	proopiomelanocortin	XENTR|Xenbase=XB-GENE-483703|UniProtKB=Q5M8F2	Proopiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00036	Interleukin signaling pathway	P00990	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=13681|UniProtKB=Q96JQ0	Protocadherin-16	IDA	8120095	PubMed	PTHR43956:SF6	PROTOCADHERIN-16
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	XENTR|Xenbase=XB-GENE-484032|UniProtKB=F6QWD3	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00056	VEGF signaling pathway	P01411	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00005	Angiogenesis	P00217	STAT3	MONDO|Ensembl=ENSMODG00000028212|UniProtKB=F7BYN4	Signal transducer and activator of transcription	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04393	Ras Pathway	P04570	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P06959	CCKR signaling map	P07021	MAPK7	HUMAN|HGNC=6880|UniProtKB=Q13164	Mitogen-activated protein kinase 7	RCA	16376520	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	TAS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-050417-59|UniProtKB=Q15KE4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00006	Apoptosis signaling pathway	P00279	endoG	BOVIN|Ensembl=ENSBTAG00000012484|UniProtKB=P38447	Endonuclease G, mitochondrial	ISS	11452314	PubMed	PTHR13966:SF5	ENDONUCLEASE G, MITOCHONDRIAL
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CAEBR|Gene=CBG18715|UniProtKB=A8XTZ1	Phosphoinositide phospholipase C	ISS			PTHR10336:SF91	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IPI	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00038	JAK/STAT signaling pathway	P01027	STAT	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	12191995	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P04393	Ras Pathway	P04542	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01093	AChE	CAEEL|WormBase=WBGene00000036|UniProtKB=G5EDV9	Carboxylic ester hydrolase	IC			PTHR43918:SF6	CARBOXYLIC ESTER HYDROLASE
P04397	p53 pathway by glucose deprivation	P04639	AMPK	MONDO|Ensembl=ENSMODG00000020303|UniProtKB=F7BFG2	Uncharacterized protein	ISS			PTHR24343:SF306	5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-040718-93|UniProtKB=Q6DGZ5	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	RAT|RGD=619877|UniProtKB=P19804	Nucleoside diphosphate kinase B	ISS			PTHR11349:SF57	NUCLEOSIDE DIPHOSPHATE KINASE B
P00057	Wnt signaling pathway	P01444	Wnt	XENTR|Xenbase=XB-GENE-479567|UniProtKB=A4ZGP0	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P00010	B cell activation	P00400	Btk	HUMAN|HGNC=1133|UniProtKB=Q06187	Tyrosine-protein kinase BTK	IGI	10521450	PubMed	PTHR24418:SF92	TYROSINE-PROTEIN KINASE BTK
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01457	GBeta	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00019	Endothelin signaling pathway	P00590	IP3 R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00005	Angiogenesis	P00211	GSK3beta	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00920	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00057	Wnt signaling pathway	P01443	Phospholipase C	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	BOVIN|Ensembl=ENSBTAG00000014828|UniProtKB=F1N1E0	Uncharacterized protein	ISS	14507926	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00780	Microtubule	BOVIN|Ensembl=ENSBTAG00000006969|UniProtKB=Q2KJD0	Tubulin beta-5 chain	ISS	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00049	Parkinson disease	P01208	Hsp70	TAKRU|Ensembl=ENSTRUG00000000384|UniProtKB=H2RL84	Uncharacterized protein	IDA	12150907	PubMed	PTHR19375:SF256	HSP70 PROTEIN-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DANRE|ZFIN=ZDB-GENE-041001-104|UniProtKB=Q5TZD4	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00029	Huntington disease	P00805	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00981	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00049	Parkinson disease	P01227	20S proteasome	YEAST|SGD=S000000896|UniProtKB=P25451	Proteasome subunit beta type-3	TAS	12859888	PubMed	PTHR11599:SF62	PROTEASOME SUBUNIT BETA TYPE-3
P00045	Notch signaling pathway	P01104	Serrate	BOVIN|Ensembl=ENSBTAG00000012817|UniProtKB=E1BDN7	Delta-like protein	ISS	1286675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	DANRE|ZFIN=ZDB-GENE-020125-4|UniProtKB=F1QKT1	Uncharacterized protein	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00057	Wnt signaling pathway	P01457	GBeta	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01080	AChE	MACMU|Ensembl=ENSMMUG00000021257|UniProtKB=F7HPD6	Carboxylic ester hydrolase	ISS	86008285	PubMed	PTHR43918:SF3	ACETYLCHOLINESTERASE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00922	Collagen	HUMAN|HGNC=2198|UniProtKB=P08123	Collagen alpha-2(I) chain	IDA	10778855	PubMed	PTHR24023:SF568	COLLAGEN ALPHA-2 I  CHAIN
P00010	B cell activation	P00398	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00048	PI3 kinase pathway	P01179	PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MONDO|Ensembl=ENSMODG00000024440|UniProtKB=F7DJJ2	Muscarinic acetylcholine receptor	ISS	91373358	PubMed	PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00018	EGF receptor signaling pathway	P00547	PP2A	DANRE|ZFIN=ZDB-GENE-041014-4|UniProtKB=A4QP33	Ppp2r5c protein	ISS			PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P02772	Pyruvate metabolism	P03133	Pyruvate Dehydrogenase	PYRAE|EnsemblGenome=PAE2644|UniProtKB=Q8ZUR8	Pyruvate dehydrogenase E1 alpha subunit	IEA	11792869	PubMed	PTHR11516:SF41	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01167	Ets	RAT|RGD=1309837|UniProtKB=Q4Z8P1	Friend leukemia integration 1	ISS	15298723	PubMed	PTHR11849:SF161	FRIEND LEUKEMIA INTEGRATION 1 TRANSCRIPTION FACTOR
P00009	Axon guidance mediated by netrin	P00363	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00518	Rho GEFs	PANTR|Ensembl=ENSPTRG00000011039|UniProtKB=H2QGF2	Uncharacterized protein	ISS	12024019	PubMed	PTHR12673:SF122	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	ANOGA|EnsemblGenome=AGAP002578|UniProtKB=F5HKU8	AGAP002578-PB	ISS	14624853	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	P01428	Frizzled	HUMAN|HGNC=4038|UniProtKB=Q9UP38	Frizzled-1	IDA	8717036	PubMed	PTHR11309:SF81	FRIZZLED-1
P00029	Huntington disease	P00774	Dynein complex	MONDO|Ensembl=ENSMODG00000024116|UniProtKB=F6V553	Uncharacterized protein	ISS	9454836	PubMed	PTHR11886:SF52	DYNEIN LIGHT CHAIN 1, CYTOPLASMIC
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00034	Integrin signalling pathway	P00916	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IGI	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00015	Circadian clock system	G01501	cry	MOUSE|MGI=MGI=1270841|UniProtKB=P97784	Cryptochrome-1	IEP	14507900	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00037	Ionotropic glutamate receptor pathway	P01023	CaMKII	DROME|FlyBase=FBgn0264607|UniProtKB=Q00168	Calcium/calmodulin-dependent protein kinase type II alpha chain	ISS	12888804	PubMed	PTHR43940:SF1	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN
P00021	FGF signaling pathway	P00629	PP2A	PANTR|Ensembl=ENSPTRG00000017377|UniProtKB=H2RCR7	Uncharacterized protein	ISS	1849734	PubMed	PTHR11871:SF1	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B BETA ISOFORM
P00021	FGF signaling pathway	P00634	MEKK1-5	MOUSE|MGI=MGI=1346873|UniProtKB=Q61083	Mitogen-activated protein kinase kinase kinase 2	ISS	8621389	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	20216076	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00059	p53 pathway	P01482	ARF	HUMAN|HGNC=1787|UniProtKB=P42771	Cyclin-dependent kinase inhibitor 2A	IDA	12082609	PubMed	PTHR24148:SF47	CYCLIN-DEPENDENT KINASE 4 INHIBITOR B-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00018	EGF receptor signaling pathway	P00551	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IGI	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	IC	15313841	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	MACMU|Ensembl=ENSMMUG00000006553|UniProtKB=F7HRY3	Uncharacterized protein	ISS	10409711	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CANLF|Ensembl=ENSCAFG00000009967|UniProtKB=F1PGZ2	Muscarinic acetylcholine receptor	ISS			PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00551	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IGI	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00260	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00015	Circadian clock system	P00501	Clock	CANLF|Ensembl=ENSCAFG00000002140|UniProtKB=F1PSD8	Uncharacterized protein	ISS	10198158	PubMed	PTHR23042:SF2	CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04372	5-Hydroxytryptamine degredation	P04401	Monoamine Oxidase	BACSU|EnsemblGenome=BSU19020|UniProtKB=O34363	Putative L-amino-acid oxidase YobN	ISS			PTHR10742:SF345	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00229	SPK	MOUSE|MGI=MGI=1861380|UniProtKB=Q9JIA7	Sphingosine kinase 2	ISS			PTHR12358:SF40	SPHINGOSINE KINASE 2
P00036	Interleukin signaling pathway	P00983	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00562	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	HUMAN|HGNC=7851|UniProtKB=Q13232	Nucleoside diphosphate kinase 3	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ORNAN|Ensembl=ENSOANG00000000460|UniProtKB=F7F4W9	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	RAT|RGD=621516|UniProtKB=G3V6P8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00021	FGF signaling pathway	P00637	MKK4,7	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00036	Interleukin signaling pathway	P00990	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00020	FAS signaling pathway	P00615	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00009	Axon guidance mediated by netrin	P00366	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01409	cPLA2	DANRE|ZFIN=ZDB-GENE-990415-45|UniProtKB=P50392	Cytosolic phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01435	SWI/SNF	HUMAN|HGNC=11103|UniProtKB=Q12824	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1	IDA	11532957	PubMed	PTHR10019:SF5	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY B MEMBER 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00101	BACE-1	MACMU|Ensembl=ENSMMUG00000007785|UniProtKB=F7CQI1	Beta-secretase 1 isoform A preproprotein	ISS	10956649	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000002297|UniProtKB=F1N167	Uncharacterized protein	ISS			PTHR11824:SF7	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00007	Axon guidance mediated by semaphorins	P00340	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	15470041	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00012	Cadherin signaling pathway	P00463	betacatenin	CANLF|Ensembl=ENSCAFG00000005204|UniProtKB=B6V8E6	Catenin beta-1	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MACMU|Ensembl=ENSMMUG00000019112|UniProtKB=F6T8S6	N-methyl D-aspartate receptor subtype 2B	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00016	Cytoskeletal regulation by Rho GTPase	P00510	mDia	MOUSE|MGI=MGI=1194490|UniProtKB=O08808	Protein diaphanous homolog 1	ISS			PTHR23213:SF17	PROTEIN DIAPHANOUS HOMOLOG 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01080	AChE	MOUSE|MGI=MGI=894278|UniProtKB=Q03311	Cholinesterase	IC			PTHR43918:SF5	CHOLINESTERASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01173	STAT	PANTR|Ensembl=ENSPTRG00000009199|UniProtKB=H2QD19	Signal transducer and activator of transcription	ISS	14662325	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	ISS	12104050	PubMed	PTHR24070:SF189	GTPASE NRAS
P00006	Apoptosis signaling pathway	P00321	HSP70	DANRE|ZFIN=ZDB-GENE-031001-11|UniProtKB=Q6P3L3	Heat shock protein 5	ISS	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00220	c-Jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANAL|CGD=CAL0006065|UniProtKB=Q59LC4	Phosphoinositide phospholipase C	TAS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05940	GRK5	CANLF|Ensembl=ENSCAFG00000012129|UniProtKB=E2RBX1	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF27	G PROTEIN-COUPLED RECEPTOR KINASE 5
P00019	Endothelin signaling pathway	P00582	COX-2	HUMAN|HGNC=9605|UniProtKB=P35354	Prostaglandin G/H synthase 2	IGI	12871860	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	RAT|RGD=620325|UniProtKB=Q78EH2	Proprotein convertase subtilisin/kexin type 4	IDA			PTHR42884:SF16	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 4
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02920	dCTP deaminase	MOUSE|MGI=MGI=1914007|UniProtKB=Q6P6J0	tRNA-specific adenosine deaminase 2	ISS			PTHR11079:SF92	TRNA-SPECIFIC ADENOSINE DEAMINASE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Ensembl=ENSPTRG00000013825|UniProtKB=H2RAK4	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00010	B cell activation	P00379	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00048	PI3 kinase pathway	P01206	14-3-3	CANLF|Ensembl=ENSCAFG00000000580|UniProtKB=F1PBL1	Uncharacterized protein	ISS	92362864	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00004	Alzheimer disease-presenilin pathway	P00164	Nectin 1alpha N-terminal fragment	MACMU|Ensembl=ENSMMUG00000008274|UniProtKB=F7HBK1	Uncharacterized protein	ISS	12376527	PubMed	PTHR23277:SF69	NECTIN-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MOUSE|MGI=MGI=2444552|UniProtKB=Q8BFZ3	Beta-actin-like protein 2	IC	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05970	TH	BOVIN|Gene=TH|UniProtKB=P17289	Tyrosine 3-monooxygenase	ISS	12814656	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00025	Hedgehog signaling pathway	P00692	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00059	p53 pathway	P01486	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00547	PP2A	XENTR|Xenbase=XB-GENE-484003|UniProtKB=Q6P365	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	MOUSE|MGI=MGI=97453|UniProtKB=P35454	Oxytocin-neurophysin 1	ISS	3768139	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CANLF|Ensembl=ENSCAFG00000001738|UniProtKB=E2RDG9	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00048	PI3 kinase pathway	P01188	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00048	PI3 kinase pathway	P01181	GSK3	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00562	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00462	Casein kinase II	TAKRU|Ensembl=ENSTRUG00000000811|UniProtKB=H2RP90	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00018	EGF receptor signaling pathway	P00547	PP2A	XENTR|Xenbase=XB-GENE-957248|UniProtKB=Q6GLE6	Serine/threonine-protein phosphatase	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	BOVIN|Ensembl=ENSBTAG00000020756|UniProtKB=A6QLB8	GSK3A protein	ISS	12086949	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00054	Toll receptor signaling pathway	P01375	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04559	Rac	DICDI|dictyBase=DDB_G0279605|UniProtKB=P34148	Rho-related protein racB	ISS	11973360	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	HUMAN|HGNC=1401|UniProtKB=Q02641	Voltage-dependent L-type calcium channel subunit beta-1	IDA	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00021	FGF signaling pathway	P00645	Rac	CHICK|Ensembl=ENSGALG00000002859|UniProtKB=F6UBD2	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	9009705	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	HUMAN|HGNC=9509|UniProtKB=P49810	Presenilin-2	IDA	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P05731	GABA-B receptor II signaling	P05754	Ggamma	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00048	PI3 kinase pathway	P01190	PDK1 ACT	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00010	B cell activation	P00373	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IGI	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00558	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00011	Blood coagulation	P00406	Fibrinogen	PANTR|Ensembl=ENSPTRG00000016535|UniProtKB=H2QQB5	Uncharacterized protein	ISS	6575700	PubMed	PTHR19143:SF232	FIBRINOGEN ALPHA CHAIN
P00010	B cell activation	P00385	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	PUCGT|EnsemblGenome=PGTG_11337|UniProtKB=E3KLJ3	Calmodulin	ISS	7514101	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01095	beta	BOVIN|Ensembl=ENSBTAG00000019242|UniProtKB=P04758	Acetylcholine receptor subunit beta	ISS	22213672	PubMed	PTHR18945:SF477	ACETYLCHOLINE RECEPTOR SUBUNIT BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00025	Hedgehog signaling pathway	P00682	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00114	actin	STRPU|Gene=CYIIIB|UniProtKB=P18499	Actin, cytoskeletal 3B	IDA	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00010	B cell activation	P00384	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00219	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IGI	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00059	p53 pathway	P01486	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06007	alpha-MSH	PANTR|Ensembl=ENSPTRG00000011721|UniProtKB=H2R8Y3	Uncharacterized protein	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02768	Proline biosynthesis	P03114	Glutamyl kinase	MYCTU|EnsemblGenome=Rv2439c|UniProtKB=P9WHU9	Glutamate 5-kinase	ISS			PTHR43654:SF3	GLUTAMATE 5-KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	STRCO|Gene=CAA20824|UniProtKB=O88070	Putative glutamine synthetase	ISS			PTHR43785:SF5	SUBFAMILY NOT NAMED
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	DANRE|ZFIN=ZDB-GENE-990415-247|UniProtKB=P79732	Ribonucleoside-diphosphate reductase large subunit	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00021	FGF signaling pathway	P00645	Rac	PHYPA|Gene=PHYPADRAFT_170715|UniProtKB=A9TLC7	Rop-family small GTPase	ISS			PTHR24072:SF194	RAC-LIKE GTP-BINDING PROTEIN ARAC4-RELATED
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	HUMAN|HGNC=174|UniProtKB=Q13705	Activin receptor type-2B	TAS	11252892	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P00021	FGF signaling pathway	P00634	MEKK1-5	BOVIN|Ensembl=ENSBTAG00000013790|UniProtKB=E1B847	Uncharacterized protein	ISS	12168099	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	IDA	12461178	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00034	Integrin signalling pathway	P00907	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DAPPU|EnsemblGenome=DAPPUDRAFT_59367|UniProtKB=E9H7Z0	Guanine nucleotide-binding protein G(O) subunit alpha 1	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P05915	Opioid proenkephalin pathway	P05989	leu-Enkephalin	DANRE|ZFIN=ZDB-GENE-030729-31|UniProtKB=A8E7S2	Uncharacterized protein	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	MONDO|Ensembl=ENSMODG00000020981|UniProtKB=F6S570	Uncharacterized protein	ISS	2433589	PubMed	PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P00046	Oxidative stress response	P01131	MKP5	ORNAN|Ensembl=ENSOANG00000001437|UniProtKB=F7GDU1	Uncharacterized protein	ISS	10597297	PubMed	PTHR10159:SF299	DUAL SPECIFICITY PROTEIN PHOSPHATASE 10
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95810|UniProtKB=Q9Z2W9	Glutamate receptor 3	ISS	12941441	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	DROME|FlyBase=FBgn0011582|UniProtKB=P41596	Dopamine receptor 1	ISS	9700720	PubMed	PTHR43893:SF6	DOPAMINE RECEPTOR 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00729	Goalpha	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	IDA	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	NEUCR|EnsemblGenome=EFNCRG00000004240|UniProtKB=Q01386	cAMP-dependent protein kinase regulatory subunit	IC	91298951	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	RAT|RGD=67385|UniProtKB=Q8VGC3	Voltage-dependent L-type calcium channel subunit beta-2	IDA	20088160	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	10514528	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00005	Angiogenesis	P00226	Delta/Serrate	BOVIN|Ensembl=ENSBTAG00000012817|UniProtKB=E1BDN7	Delta-like protein	ISS	7697721	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P02759	Pyridoxal-5-phosphate biosynthesis	P03058	Phosphohydroxythreonine aminotransferase	ENTHI|EnsemblGenome=EHI_026360|UniProtKB=Q60I38	Phosphoserine aminotransferase	ISS			PTHR43247:SF2	PHOSPHOSERINE AMINOTRANSFERASE
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	ARATH|TAIR=AT5G37600|UniProtKB=Q56WN1	Glutamine synthetase cytosolic isozyme 1-1	ISS			PTHR20852:SF79	GLUTAMINE SYNTHETASE CYTOSOLIC ISOZYME 1-1-RELATED
P00029	Huntington disease	P00785	Cytochrome c	DROME|FlyBase=FBgn0035600|UniProtKB=Q9VRL0	Cytochrome c1, isoform A	IDA	15163634	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	MOUSE|MGI=MGI=1346037|UniProtKB=Q9WTL4	Insulin receptor-related protein	ISS	6754360	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00006	Apoptosis signaling pathway	P00302	ATF	CANLF|Ensembl=ENSCAFG00000013332|UniProtKB=F1PCQ4	Uncharacterized protein	ISS	9819389	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00034	Integrin signalling pathway	P00916	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P06664	Gonadotropin-releasing hormone receptor pathway	G06891	Junc	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	RCA	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00012	Cadherin signaling pathway	P00477	GSK3beta	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	RAT|RGD=621515|UniProtKB=P61954	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	ISS			PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P04393	Ras Pathway	P04542	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02765	Phenylalanine biosynthesis	P03101	Aromatic amino acid aminotransferase	PSEAE|EnsemblGenome=PA3139|UniProtKB=P72173	Aspartate aminotransferase	ISS			PTHR11879:SF10	ASPARTATE AMINOTRANSFERASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04393	Ras Pathway	P04572	JNK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	ISS	12040174	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00006	Apoptosis signaling pathway	P00269	MAPK	CHLRE|EnsemblGenome=CHLREDRAFT_193901|UniProtKB=Q9FXT7	Mitogen-activated protein kinase	ISS	11275338	gi	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DROME|FlyBase=FBgn0001122|UniProtKB=P16378	G protein alpha o subunit	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05916	Opioid prodynorphin pathway	P05998	Kappa Receptor	MOUSE|MGI=MGI=97439|UniProtKB=P33534	Kappa-type opioid receptor	RCA	11259498	PubMed	PTHR24229:SF1	KAPPA-TYPE OPIOID RECEPTOR
P00053	T cell activation	P01305	Calmodulin	ORYSJ|EnsemblGenome=OS05G0491100|UniProtKB=Q6F332	Calmodulin-2	ISS	3885394	PubMed	PTHR23050:SF324	CALMODULIN-2-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00131	HAC1	MONDO|Ensembl=ENSMODG00000001127|UniProtKB=F7D527	Uncharacterized protein	ISS			PTHR44028:SF2	TRIPARTITE MOTIF-CONTAINING PROTEIN 2
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000009085|UniProtKB=H2RDQ2	Uncharacterized protein	ISS	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	BOVIN|Ensembl=ENSBTAG00000005800|UniProtKB=F1N3G8	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	CHLRE|EnsemblGenome=CHLREDRAFT_193901|UniProtKB=Q9FXT7	Mitogen-activated protein kinase	TAS			PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00004	Alzheimer disease-presenilin pathway	P00114	actin	TAKRU|Ensembl=ENSTRUG00000014318|UniProtKB=H2UI49	Uncharacterized protein	IDA	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00018	EGF receptor signaling pathway	P00563	Gab	PANTR|Ensembl=ENSPTRG00000004115|UniProtKB=H2R3E1	GRB2-associated binding protein 2	ISS	16758156	gi	PTHR12156:SF4	GRB2-ASSOCIATED-BINDING PROTEIN 2
P00029	Huntington disease	P00774	Dynein complex	EMENI|EnsemblGenome=CADANIAG00002278|UniProtKB=O94111	Dynein light chain, cytoplasmic	IPI	9454836	PubMed	PTHR11886:SF35	DYNEIN LIGHT CHAIN 2, CYTOPLASMIC
P00010	B cell activation	P00384	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	MOUSE|MGI=MGI=1926368|UniProtKB=Q9R0N5	Synaptotagmin-5	RCA			PTHR10024:SF282	SYNAPTOTAGMIN-5
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000001187|UniProtKB=F6R8N9	Mitogen-activated protein kinase	ISS	11875070	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00036	Interleukin signaling pathway	P00983	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05918	p38 MAPK pathway	P06034	MKK4	CANLF|Ensembl=ENSCAFG00000017851|UniProtKB=F1PBB6	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DROME|FlyBase=FBgn0000046|UniProtKB=P10981	Actin-87E	IC	14684598	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00005	Angiogenesis	P00184	Src	CHICK|Ensembl=ENSGALG00000003855|UniProtKB=P00523	Proto-oncogene tyrosine-protein kinase Src	ISS	11078745	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00009	Axon guidance mediated by netrin	P00364	cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	SCHPO|PomBase=SPBC725.01|UniProtKB=O94320	Aspartate aminotransferase, mitochondrial	ISS			PTHR11879:SF10	ASPARTATE AMINOTRANSFERASE
P00010	B cell activation	P00369	MEKK	MONDO|Ensembl=ENSMODG00000009983|UniProtKB=F6USY2	Uncharacterized protein	ISS	8649450	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00054	Toll receptor signaling pathway	P01375	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	ISS	10207617	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	TAS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00591	PLCbeta	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	BOVIN|Ensembl=ENSBTAG00000000469|UniProtKB=P67774	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	TAS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	DANRE|ZFIN=ZDB-GENE-010705-1|UniProtKB=Q90Z40	Guanine nucleotide-binding protein subunit gamma	IDA	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00045	Notch signaling pathway	P01100	CoA	ANOGA|EnsemblGenome=AGAP004434|UniProtKB=Q7QA53	AGAP004434-PA	TAS	11112321	PubMed	PTHR22880:SF124	HISTONE ACETYLTRANSFERASE KAT2A
P00036	Interleukin signaling pathway	P00967	c-fos	RAT|RGD=2626|UniProtKB=P12841	Proto-oncogene c-Fos	TAS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00059	p53 pathway	G01579	PTEN	XENTR|Xenbase=XB-GENE-491433|UniProtKB=B1H2U0	Pten protein	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P06959	CCKR signaling map	G07272	MYC	HUMAN|HGNC=7553|UniProtKB=P01106	Myc proto-oncogene protein	RCA	18515095	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P05915	Opioid proenkephalin pathway	P05994	G-protein	DAPPU|EnsemblGenome=DAPPUDRAFT_206575|UniProtKB=E9FUX0	Guanine nucleotide binding protein, beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P02747	Histidine biosynthesis	P02992	Imidazol glycerol phosphate synthase	STRCO|EnsemblGenome=CAB51443|UniProtKB=P16249	Imidazole glycerol phosphate synthase subunit HisH	ISS			PTHR42701:SF1	IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISH
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	IDA	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00012	Cadherin signaling pathway	P00470	F-actin	TRIAD|EnsemblGenome=TriadG35956|UniProtKB=Q7YTV5	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00628	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MOUSE|MGI=MGI=95822|UniProtKB=Q01098	Glutamate receptor ionotropic, NMDA 2C	ISS	11319238	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00034	Integrin signalling pathway	P00951	Jnk	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	IC	11319238	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000008270|UniProtKB=H2QBE5	Uncharacterized protein	ISS	11953314	PubMed	PTHR24027:SF319	CADHERIN-1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=101848|UniProtKB=P62881	Guanine nucleotide-binding protein subunit beta-5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	DAPPU|EnsemblGenome=DAPPUDRAFT_301140|UniProtKB=E9HGM4	Putative uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	HUMAN|HGNC=1442|UniProtKB=P62158	Calmodulin	IDA	10487978	PubMed	PTHR23050:SF311	CALMODULIN
P04393	Ras Pathway	P04544	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	8262390	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01142	p90RSK	MOUSE|MGI=MGI=104557|UniProtKB=P18654	Ribosomal protein S6 kinase alpha-3	ISS	10480933	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P06587	Nicotine pharmacodynamics pathway	P06614	TH	PANTR|Ensembl=ENSPTRG00000003173|UniProtKB=H2Q2W7	Uncharacterized protein	ISS	12480184	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	MOUSE|MGI=MGI=1321159|UniProtKB=P63330	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05730	Endogenous cannabinoid signaling	P05751	Galpha	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MONDO|Ensembl=ENSMODG00000016595|UniProtKB=F6ZDB2	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00049	Parkinson disease	P01224	UbcH7	XENTR|Xenbase=XB-GENE-970758|UniProtKB=F6W7B6	Uncharacterized protein (Fragment)	ISS			PTHR24068:SF116	AT26201P-RELATED
P00056	VEGF signaling pathway	P01411	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MONDO|Ensembl=ENSMODG00000007194|UniProtKB=F6X9N6	Actin-related protein 2/3 complex subunit 5	ISS	10322212	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00034	Integrin signalling pathway	P00944	Actin	PANTR|Ensembl=ENSPTRG00000018890|UniProtKB=Q5R1X3	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IDA	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00021	FGF signaling pathway	P00623	FGF	PANTR|Ensembl=ENSPTRG00000004001|UniProtKB=H2Q4B5	Fibroblast growth factor	ISS			PTHR11486:SF26	FIBROBLAST GROWTH FACTOR 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00060	Ubiquitin proteasome pathway	P01490	E3	PANTR|Ensembl=ENSPTRG00000005203|UniProtKB=H2R792	Mdm2 p53 binding protein homolog	ISS	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	MOUSE|MGI=MGI=99512|UniProtKB=Q03366	C-C motif chemokine 7	IDA	11777981	PubMed	PTHR12015:SF78	C-C MOTIF CHEMOKINE 7
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8440264	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BOVIN|Ensembl=ENSBTAG00000005714|UniProtKB=Q3ZC07	Actin, alpha cardiac muscle 1	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	RAT|RGD=3425|UniProtKB=P97887	Presenilin-1	IDA	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-969601|UniProtKB=Q28H40	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=109356|UniProtKB=O09044	Synaptosomal-associated protein 23	IC	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00019	Endothelin signaling pathway	P00591	PLCbeta	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00059	p53 pathway	P01486	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00047	PDGF signaling pathway	P01162	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00048	PI3 kinase pathway	P01177	P110ACT	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00238	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00005	Angiogenesis	P00235	c-Fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00029	Huntington disease	P00790	beta-Tubulin	MOUSE|MGI=MGI=1915201|UniProtKB=Q922F4	Tubulin beta-6 chain	TAS	12932731	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000000289|UniProtKB=F7A9T0	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00005	Angiogenesis	P00208	MEKK1	PANTR|Ensembl=ENSPTRG00000016891|UniProtKB=H2R5K3	Uncharacterized protein	ISS	12168099	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	CANLF|Ensembl=ENSCAFG00000004381|UniProtKB=J9JH96	Uncharacterized protein	ISS	7476890	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00049	Parkinson disease	P01238	14-3-3	DANRE|ZFIN=ZDB-GENE-011115-1|UniProtKB=Q6PC29	14-3-3 protein gamma-1	ISS	10407019	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	DROME|FlyBase=FBgn0023416|UniProtKB=Q9V9R3	Ac3, isoform A	IGI	20123737	PubMed	PTHR11920:SF291	ADENYLATE CYCLASE TYPE 3
P02746	Heme biosynthesis	P02980	Coproporphyrinogen Oxidase (oxygen dependent)	ARATH|TAIR=AT4G03205|UniProtKB=Q93Z96	Coproporphyrinogen-III oxidase 2, chloroplastic	ISS			PTHR10755:SF0	OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL
P00049	Parkinson disease	P01208	Hsp70	DANRE|ZFIN=ZDB-GENE-121214-31|UniProtKB=F1R9V3	Uncharacterized protein	IDA	12150907	PubMed	PTHR19375:SF239	HEAT SHOCK COGNATE 71 KDA PROTEIN
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	PANTR|Ensembl=ENSPTRG00000023608|UniProtKB=H2QZZ2	Uncharacterized protein	ISS	11554554	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000010521|UniProtKB=F7DQK7	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	CHICK|Gene=PSEN2|UniProtKB=Q90X07	Presenilin-2	TAS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00006	Apoptosis signaling pathway	P00273	p53	PANTR|Ensembl=ENSPTRG00000008703|UniProtKB=H2QC53	Cellular tumor antigen p53	ISS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00029	Huntington disease	P00807	Actin	ANOGA|EnsemblGenome=AGAP000651|UniProtKB=P84185	Actin-5C	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00010	B cell activation	P00383	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00036	Interleukin signaling pathway	P00968	Ikk	PANTR|Ensembl=ENSPTRG00000020202|UniProtKB=H2QW34	Uncharacterized protein	ISS	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	IDA	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01076	CAT	MACMU|Ensembl=ENSMMUG00000004692|UniProtKB=F6RM01	Uncharacterized protein	ISS	92155737	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P04395	Vasopressin synthesis	P04590	Vasopressin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MOUSE|MGI=MGI=3710243|UniProtKB=A2AQP0	Myosin-7B	ISS	89264452	PubMed	PTHR13140:SF358	MYOSIN-7B
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PANTR|Ensembl=ENSPTRG00000013680|UniProtKB=H2QKN9	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF112	TUBULIN BETA-1 CHAIN
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IGI	7937853	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00005	Angiogenesis	P00210	eNOS	HUMAN|HGNC=7876|UniProtKB=P29474	Nitric oxide synthase, endothelial	IEP	9837777	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	HUMAN|HGNC=4401|UniProtKB=O14775	Guanine nucleotide-binding protein subunit beta-5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04393	Ras Pathway	P04570	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	RAT|RGD=3696|UniProtKB=P51907	Excitatory amino acid transporter 3	ISS	94365697	PubMed	PTHR11958:SF69	EXCITATORY AMINO ACID TRANSPORTER 3
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	TAKRU|Ensembl=ENSTRUG00000015213|UniProtKB=H2UPJ1	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF356	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	11591316	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IDA	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00021	FGF signaling pathway	P00629	PP2A	XENTR|Xenbase=XB-GENE-957248|UniProtKB=Q6GLE6	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	15313841	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00020	FAS signaling pathway	P00616	Nuclear Lamin	RAT|RGD=620456|UniProtKB=P48679	Prelamin-A/C	TAS	11165516	PubMed	PTHR23239:SF158	PRELAMIN-A/C
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	ISS	15313841	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00005	Angiogenesis	P00219	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05731	GABA-B receptor II signaling	P05754	Ggamma	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ARATH|TAIR=AT5G59370|UniProtKB=P53494	Actin-4	IC	14684598	PubMed	PTHR11937:SF366	ACTIN-4
P00021	FGF signaling pathway	P00631	Grb2	HUMAN|HGNC=4562|UniProtKB=Q13588	GRB2-related adapter protein	ISS	11971956	PubMed	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	TAS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	ISS	9851932	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00056	VEGF signaling pathway	P01407	Erk	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	RAT|RGD=2736|UniProtKB=P35439	Glutamate receptor ionotropic, NMDA 1	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000001867|UniProtKB=H2Q0X8	Adenosine receptor A1	ISS	12515326	PubMed	PTHR24246:SF1	ADENOSINE RECEPTOR A1
P04393	Ras Pathway	P04569	Cdc42	TAKRU|Ensembl=ENSTRUG00000013411|UniProtKB=H2UB84	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00750	Rhodopsin kinase	RAT|RGD=619712|UniProtKB=Q63651	Rhodopsin kinase	IDA	8260489	PubMed	PTHR24355:SF11	RHODOPSIN KINASE
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	DANRE|ZFIN=ZDB-GENE-000330-4|UniProtKB=Q1MTI1	Uncharacterized protein	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00010	B cell activation	P00371	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00010	B cell activation	P00367	NFAT	MOUSE|MGI=MGI=1920431|UniProtKB=Q8K120	Nuclear factor of activated T-cells, cytoplasmic 4	IDA	12015605	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00054	Toll receptor signaling pathway	P01367	MKK3	CHICK|Ensembl=ENSGALG00000004735|UniProtKB=F1NHE1	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00049	Parkinson disease	P01211	ERK	ORYSJ|EnsemblGenome=OS06G0699400|UniProtKB=Q5Z859	Mitogen-activated protein kinase 4	IDA	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P05731	GABA-B receptor II signaling	P05752	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00046	Oxidative stress response	P01132	c-jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CAEEL|WormBase=WBGene00003774|UniProtKB=G5EGQ9	NMDA class glutamate Receptor	IC	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00053	T cell activation	P01295	vav	HUMAN|HGNC=12658|UniProtKB=P52735	Guanine nucleotide exchange factor VAV2	IGI	14623913	PubMed	PTHR22826:SF95	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV2
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000007445|UniProtKB=F6SWI4	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	RCA	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00060	Ubiquitin proteasome pathway	P01491	E2	CAEBR|Gene=CBG15726|UniProtKB=A8XMM5	Protein CBR-UBC-20	ISS			PTHR44020:SF2	UBIQUITIN-CONJUGATING ENZYME E2 K
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P02769	Purine metabolism	P03116	Xanthine Oxidase	HUMAN|HGNC=12805|UniProtKB=P47989	Xanthine dehydrogenase/oxidase	ISS	11307944	PubMed	PTHR11908:SF80	XANTHINE DEHYDROGENASE/OXIDASE
P00059	p53 pathway	G04694	p110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00572	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00049	Parkinson disease	P01211	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05915	Opioid proenkephalin pathway	P05989	leu-Enkephalin	MOUSE|MGI=MGI=104629|UniProtKB=P22005	Proenkephalin-A	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	12805548	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00021	FGF signaling pathway	P00636	FGFR1-4	MONDO|Ensembl=ENSMODG00000008525|UniProtKB=F7DHF8	Fibroblast growth factor receptor	ISS	1373495	PubMed	PTHR24416:SF130	FIBROBLAST GROWTH FACTOR RECEPTOR 2
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00023	General transcription regulation	P00658	TBP-associated factors	DROME|FlyBase=FBgn0002842|UniProtKB=Q9VP40	Spermatocyte arrest	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P06217	Toll pathway-drosophila	P06348	SLMB	DROME|Gene=Dmel_CG3412|UniProtKB=A0A0B4KHK1	Supernumerary limbs, isoform B	IDA	1007443	PubMed	PTHR44038:SF2	F-BOX/WD REPEAT-CONTAINING PROTEIN 1A
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	RAT|RGD=62045|UniProtKB=Q99PS2	Casein kinase1 epsilon-2	IDA	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P05915	Opioid proenkephalin pathway	P05994	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	HUMAN|HGNC=1736|UniProtKB=P60953	Cell division control protein 42 homolog	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00034	Integrin signalling pathway	P00925	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IDA	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02926	Aspartate carbamoyltransferase	METAC|EnsemblGenome=MA_4502|UniProtKB=Q8THL2	Aspartate carbamoyltransferase	ISS			PTHR11405:SF16	ASPARTATE CARBAMOYLTRANSFERASE, CHLOROPLASTIC
P00056	VEGF signaling pathway	P01423	p38MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00059	p53 pathway	P04617	WRN	MOUSE|MGI=MGI=109635|UniProtKB=O09053	Werner syndrome ATP-dependent helicase homolog	ISS			PTHR13710:SF120	WERNER SYNDROME ATP-DEPENDENT HELICASE
P00010	B cell activation	P00382	Syk	BOVIN|Ensembl=ENSBTAG00000004767|UniProtKB=Q32PK0	Tyrosine-protein kinase	ISS	8137818	PubMed	PTHR24418:SF231	TYROSINE-PROTEIN KINASE SYK
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	DICDI|dictyBase=DDB_G0272110|UniProtKB=P51136	Glycogen synthase kinase-3	IDA	7813009	PubMed	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04398	p53 pathway feedback loops 2	P04653	cdk2	TAKRU|Ensembl=ENSTRUG00000018471|UniProtKB=H2VDI9	Uncharacterized protein	ISS	15660127	PubMed	PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P04393	Ras Pathway	P04567	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00054	Toll receptor signaling pathway	P01372	IKKepsilon	HUMAN|HGNC=14552|UniProtKB=Q14164	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	ISS			PTHR22969:SF10	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT EPSILON
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	MACMU|Ensembl=ENSMMUG00000005797|UniProtKB=F6VTK0	10-formyltetrahydrofolate dehydrogenase	ISS			PTHR11699:SF131	MITOCHONDRIAL 10-FORMYLTETRAHYDROFOLATE DEHYDROGENASE
P00036	Interleukin signaling pathway	P00973	PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000008430|UniProtKB=F6VB97	Uncharacterized protein	ISS			PTHR11824:SF8	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-3
P00021	FGF signaling pathway	P00637	MKK4,7	HUMAN|HGNC=6847|UniProtKB=O14733	Dual specificity mitogen-activated protein kinase kinase 7	RCA			PTHR24361:SF387	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	CAEEL|WormBase=WBGene00004776|UniProtKB=O17470	SERotonin/octopamine receptor family	ISS	8143856	PubMed	PTHR24247:SF125	5-HYDROXYTRYPTAMINE  SEROTONIN  RECEPTOR 2A, ISOFORM B
P00005	Angiogenesis	P00180	Dok-R	HUMAN|HGNC=2991|UniProtKB=O60496	Docking protein 2	ISS			PTHR21258:SF14	DOCKING PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00056	VEGF signaling pathway	P01415	MAPKAPK2/3	MOUSE|MGI=MGI=109298|UniProtKB=P49138	MAP kinase-activated protein kinase 2	ISS	14672329	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS	602425	OMIM	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00056	VEGF signaling pathway	P01413	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHICK|Gene=ACTA2|UniProtKB=P08023	Actin, aortic smooth muscle	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	MACMU|Ensembl=ENSMMUG00000021075|UniProtKB=F7GY91	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	RAT|RGD=3325|UniProtKB=P13286	Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	IDA	1370475	PubMed	PTHR44087:SF1	PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, SKELETAL MUSCLE/HEART ISOFORM
P05731	GABA-B receptor II signaling	P05754	Ggamma	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00006	Apoptosis signaling pathway	P00271	Bax	MACMU|Ensembl=ENSMMUG00000003907|UniProtKB=F6ZV96	Apoptosis regulator BAX isoform alpha	ISS	8358790	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00010	B cell activation	P00385	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00005	Angiogenesis	P00226	Delta/Serrate	PANTR|Ensembl=ENSPTRG00000006726|UniProtKB=H2RDH4	Delta-like 1 homolog	ISS			PTHR24052:SF11	PROTEIN DELTA HOMOLOG 1
P00047	PDGF signaling pathway	P01160	IP3 receptor	ANOGA|EnsemblGenome=AGAP006475|UniProtKB=Q5TQX0	AGAP006475-PA	ISS	9065779	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347740|UniProtKB=E9FXV8	Cytoplasmatic actin	ISS	11889126	PubMed	PTHR11937:SF277	SUBFAMILY NOT NAMED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P02746	Heme biosynthesis	P02981	Glutamate-1-semialdehyde aminotransferase	BACSU|EnsemblGenome=BSU08710|UniProtKB=P71084	Glutamate-1-semialdehyde 2,1-aminomutase 2	ISS			PTHR43713:SF1	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MACMU|Ensembl=ENSMMUG00000009778|UniProtKB=F6Y1M7	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF385	MYOSIN-2
P00018	EGF receptor signaling pathway	P00555	MKK4,7	BOVIN|Ensembl=ENSBTAG00000012103|UniProtKB=A5PJP8	MAP2K4 protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00056	VEGF signaling pathway	P01414	PLC-gamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00034	Integrin signalling pathway	P00909	ASAP1	MOUSE|MGI=MGI=1342335|UniProtKB=Q9QWY8	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1	RCA			PTHR23180:SF192	ARF-GAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00059	p53 pathway	P04609	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	TAS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	ISS	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00009	Axon guidance mediated by netrin	P00366	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04393	Ras Pathway	P04555	PDK	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00632	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	HUMAN|HGNC=10483|UniProtKB=P21817	Ryanodine receptor 1	ISS	8930069	PubMed	PTHR13715:SF15	RYANODINE RECEPTOR 1
P00048	PI3 kinase pathway	P01200	SHIP	HUMAN|HGNC=6080|UniProtKB=O15357	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	IDA	9824312	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02721	ATP synthesis	P02793	Cytochrome oxidase aa3	YEAST|SGD=S000007260|UniProtKB=P00401	Cytochrome c oxidase subunit 1	RCA			PTHR10422:SF18	CYTOCHROME C OXIDASE SUBUNIT 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=104510|UniProtKB=P97479	Unconventional myosin-VIIa	IC			PTHR13140:SF369	UNCONVENTIONAL MYOSIN-VIIA
P00054	Toll receptor signaling pathway	P01367	MKK3	MONDO|Ensembl=ENSMODG00000001404|UniProtKB=F7BD74	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P06959	CCKR signaling map	G06997	GCG	HUMAN|HGNC=4191|UniProtKB=P01275	Glucagon	RCA	15611055	PubMed	PTHR11418:SF0	GLUCAGON
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	PANTR|Ensembl=ENSPTRG00000006216|UniProtKB=H2Q832	Adenylate cyclase 4	ISS	9870949	PubMed	PTHR11920:SF286	ADENYLATE CYCLASE TYPE 4
P00034	Integrin signalling pathway	P00949	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	8264585	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00053	T cell activation	P01307	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=99578|UniProtKB=Q61616	D(1A) dopamine receptor	ISS			PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04393	Ras Pathway	P04559	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	10891487	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00006	Apoptosis signaling pathway	P00317	Fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00546	GAP	MOUSE|MGI=MGI=1916851|UniProtKB=Q3UHC7	Disabled homolog 2-interacting protein	ISS	14735459	gi	PTHR10194:SF26	DISABLED HOMOLOG 2-INTERACTING PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	DROME|FlyBase=FBgn0019947|UniProtKB=O02194	Presenilin homolog	IDA	12369105	PubMed	PTHR10202:SF13	PRESENILIN-2
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	CANLF|Ensembl=ENSCAFG00000012353|UniProtKB=E2RSE6	Uncharacterized protein	ISS	10956649	PubMed	PTHR42884:SF1	FURIN
P00010	B cell activation	P00369	MEKK	BOVIN|Ensembl=ENSBTAG00000008151|UniProtKB=F1MH06	Uncharacterized protein	ISS	9006902	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00047	PDGF signaling pathway	P01154	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00036	Interleukin signaling pathway	P00997	Shc	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	IC	7680960	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00562	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00055	Transcription regulation by bZIP transcription factor	P01392	TFIIH complex	MACMU|Ensembl=ENSMMUG00000018605|UniProtKB=Q5TM73	General transcription factor IIH polypeptide 4	ISS			PTHR13152:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4
P00047	PDGF signaling pathway	P01171	PLCgamma	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00047	PDGF signaling pathway	P01161	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Gene=DRD2|UniProtKB=Q9GJU1	D(2) dopamine receptor	IDA	1319557	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04393	Ras Pathway	P04579	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00053	T cell activation	P01331	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IDA	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00046	Oxidative stress response	P01135	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	GLOVI|Gene=BAC89445|UniProtKB=Q7NKH4	Aldehyde dehydrogenase	IC			PTHR43111:SF1	ALDEHYDE DEHYDROGENASE B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	DICDI|dictyBase=DDB_G0277143|UniProtKB=P36408	Guanine nucleotide-binding protein subunit beta	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00552	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00053	T cell activation	P01314	nck	MOUSE|MGI=MGI=109601|UniProtKB=Q99M51	Cytoplasmic protein NCK1	ISS	11689432	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00629	PP2A	MONDO|Ensembl=ENSMODG00000002866|UniProtKB=F7E2C0	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B	ISS	12191994	PubMed	PTHR11871:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B GAMMA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01026	KA	CHICK|Ensembl=ENSGALG00000015835|UniProtKB=F1NZT2	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P05731	GABA-B receptor II signaling	P05755	Gbeta	BOVIN|Ensembl=ENSBTAG00000006495|UniProtKB=P11017	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00046	Oxidative stress response	P01128	MEF-2	ORNAN|Ensembl=ENSOANG00000011076|UniProtKB=F7FK48	Uncharacterized protein	ISS	11274345	PubMed	PTHR11945:SF25	MYOCYTE-SPECIFIC ENHANCER FACTOR 2C
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01142	p90RSK	PANTR|Ensembl=ENSPTRG00000001972|UniProtKB=H2Q147	Ribosomal protein S6 kinase, 52kDa, polypeptide 1	ISS			PTHR15508:SF2	RIBOSOMAL PROTEIN S6 KINASE DELTA-1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00790	beta-Tubulin	ORYSJ|EnsemblGenome=OS01G0282800|UniProtKB=Q43594	Tubulin beta-1 chain	TAS	9454836	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P02751	Lysine biosynthesis	P03011	N-succinyldiaminopimelate  aminotransferase	DEIRA|EnsemblGenome=DR_0794|UniProtKB=Q9RW75	Acetylornithine/acetyl-lysine aminotransferase	IDA			PTHR11986:SF79	ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	CHICK|Ensembl=ENSGALG00000003270|UniProtKB=F1NR31	Uncharacterized protein	ISS	9700720	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00049	Parkinson disease	P01211	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	10875333	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01208	Hsp70	LEIMA|EnsemblGenome=LmjF.30.2470|UniProtKB=Q4Q745	Putative heat shock 70-related protein 1,mitochondrial	IDA	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P00029	Huntington disease	P00775	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00790	beta-Tubulin	DAPPU|EnsemblGenome=DAPPUDRAFT_300845|UniProtKB=E9HEX5	Putative uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF250	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95817|UniProtKB=Q8BMF5	Glutamate receptor ionotropic, kainate 4	ISS	12941441	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	TAS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00029	Huntington disease	P00786	ARF	BRAFL|Gene=BRAFLDRAFT_263946|UniProtKB=C3Z3B1	Putative uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF304	ADP-RIBOSYLATION FACTOR 1
P00010	B cell activation	P00398	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00036	Interleukin signaling pathway	P00990	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IC	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P06959	CCKR signaling map	P07109	p54 SRC	HUMAN|HGNC=11283|UniProtKB=P12931	Proto-oncogene tyrosine-protein kinase Src	RCA	8074224	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00034	Integrin signalling pathway	P00951	Jnk	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00049	Parkinson disease	P01208	Hsp70	CANLF|Ensembl=ENSCAFG00000000639|UniProtKB=L7N050	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF210	HEAT SHOCK 70 KDA PROTEIN 1-LIKE
P00021	FGF signaling pathway	P00632	Akt	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	ISS	12719720	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000014498|UniProtKB=F7GEI8	Uncharacterized protein	ISS	8386525	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000006307|UniProtKB=H2SSM1	Uncharacterized protein	IC			PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	MOUSE|MGI=MGI=97355|UniProtKB=P15532	Nucleoside diphosphate kinase A	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P00047	PDGF signaling pathway	P01167	Ets	HUMAN|HGNC=3316|UniProtKB=P32519	ETS-related transcription factor Elf-1	ISS	15298723	PubMed	PTHR11849:SF156	ETS-RELATED TRANSCRIPTION FACTOR ELF-1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P02763	Peptidoglycan biosynthesis	P03090	N-Acetylglucosaminyl transferase	DEIRA|EnsemblGenome=DR_0626|UniProtKB=Q9RWP0	UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase	ISS			PTHR21015:SF22	GLYCOSYLTRANSFERASE
P00029	Huntington disease	P00779	TBP	CANAL|CGD=CAL0000189736|UniProtKB=O43133	TATA-box-binding protein	IPI	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DROME|FlyBase=FBgn0030011|UniProtKB=Q9W3J1	Gbeta5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=11433|UniProtKB=Q16623	Syntaxin-1A	ISS	1321498	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00019	Endothelin signaling pathway	P00566	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	11251832	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	CHICK|Gene=MYH11|UniProtKB=P10587	Myosin-11	ISS	89264452	PubMed	PTHR13140:SF335	MYOSIN-11
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MACMU|Ensembl=ENSMMUG00000010392|UniProtKB=F7ASR8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00038	JAK/STAT signaling pathway	P01027	STAT	CANLF|Ensembl=ENSCAFG00000015509|UniProtKB=F1PNW8	Signal transducer and activator of transcription	ISS	20119183	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00019	Endothelin signaling pathway	P00589	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	NAS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00367	NFAT	MOUSE|MGI=MGI=103296|UniProtKB=P97305	Nuclear factor of activated T-cells, cytoplasmic 3	IDA	12015605	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00056	VEGF signaling pathway	P01425	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IGI	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05913	Enkephalin release	P05974	G-Protein (i)	ANOGA|EnsemblGenome=AGAP005912|UniProtKB=Q7Q6D3	AGAP005912-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00645	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	ANOGA|EnsemblGenome=AGAP004476|UniProtKB=Q7QA16	AGAP004476-PA	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00018	EGF receptor signaling pathway	P00561	STAT	PANTR|Ensembl=ENSPTRG00000009199|UniProtKB=H2QD19	Signal transducer and activator of transcription	ISS	95236292	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04393	Ras Pathway	P04547	Ras	MONDO|Ensembl=ENSMODG00000025248|UniProtKB=F7F5X1	Uncharacterized protein	ISS	9869449	PubMed	PTHR24070:SF186	GTPASE KRAS
P00029	Huntington disease	P00805	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IGI	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00005	Angiogenesis	P00256	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00058	mRNA splicing	P01474	U5	BOVIN|Gene=SNRNP40|UniProtKB=Q2HJH6	U5 small nuclear ribonucleoprotein 40 kDa protein	ISS	9774689	PubMed	PTHR44006:SF1	U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	DROME|FlyBase=FBgn0022724|UniProtKB=Q9VWY6	Transcription initiation factor TFIID subunit 8	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IDA	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01444	Wnt	CANLF|Ensembl=ENSCAFG00000008760|UniProtKB=E2RTG8	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P04398	p53 pathway feedback loops 2	P04665	AKT	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	ISS	12089061	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000007642|UniProtKB=Q0VC81	Adenosine receptor A3	ISS	12515326	PubMed	PTHR24246:SF2	ADENOSINE RECEPTOR A3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IDA	22533439	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00019	Endothelin signaling pathway	P00589	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01407	Erk	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00539	14-3-3	DANRE|ZFIN=ZDB-GENE-030131-6583|UniProtKB=Q5PRD0	14-3-3 protein beta/alpha-A	ISS	21864508	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	CANLF|Gene=VWF|UniProtKB=Q28295	von Willebrand factor	TAS	193400	OMIM	PTHR11339:SF361	VON WILLEBRAND FACTOR-RELATED
P04371	5-Hydroxytryptamine biosynthesis	P04399	Tryptophan hydroxylase	PANTR|Ensembl=ENSPTRG00000003409|UniProtKB=H2Q388	Uncharacterized protein	ISS	14597720	PubMed	PTHR11473:SF23	TRYPTOPHAN 5-HYDROXYLASE 1
P00018	EGF receptor signaling pathway	P00545	JNK1-3	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04393	Ras Pathway	P04559	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	20010089	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05938	RhoA	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	ISS	12169092	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00056	VEGF signaling pathway	P01407	Erk	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000013037|UniProtKB=F7HA59	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF46	PROTOCADHERIN-8
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	MONDO|Ensembl=ENSMODG00000009937|UniProtKB=F6R812	Uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02725	Allantoin degradation	P02817	Glycerate kinase II	ECOLI|EcoGene=EG13621|UniProtKB=P77364	Glycerate kinase	ISS			PTHR21599:SF6	GLYCERATE KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	RAT|RGD=1311985|UniProtKB=B2GV73	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00057	Wnt signaling pathway	P01448	CBP	MOUSE|MGI=MGI=1276116|UniProtKB=B2RWS6	Histone acetyltransferase p300	ISS	10823891	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P04393	Ras Pathway	P04558	p38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IDA	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00011	Blood coagulation	P00429	PN2	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	ISS	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00047	PDGF signaling pathway	P01174	Rho	PANTR|Ensembl=ENSPTRG00000006246|UniProtKB=H2R9D6	Rho GTPase activating protein 5	ISS			PTHR15377:SF4	RHO GTPASE-ACTIVATING PROTEIN 5
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P02784	Tyrosine biosynthesis	P03212	Chorismate mutase	GLOVI|Gene=BAC90646|UniProtKB=Q7NH32	Chorismate mutase AroH	ISS			PTHR21164:SF0	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00586	Gq	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06831	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	RCA	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000020588|UniProtKB=F7C0E0	Uncharacterized protein	ISS	11880265	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	PANTR|Ensembl=ENSPTRG00000014418|UniProtKB=H2QLS0	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=7595|UniProtKB=Q9UBC5	Unconventional myosin-Ia	IC			PTHR13140:SF291	UNCONVENTIONAL MYOSIN-IA
P02750	Lipoate_biosynthesis	P03003	Lipoyl-protein ligase	YEAST|SGD=S000004229|UniProtKB=Q06005	Octanoyltransferase, mitochondrial	ISS			PTHR10993:SF7	LIPOYLTRANSFERASE 2, MITOCHONDRIAL-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00006	Apoptosis signaling pathway	P00310	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02721	ATP synthesis	P02798	Cyt C	ARATH|TAIR=AT1G22840|UniProtKB=O23138	Cytochrome c-1	NAS	117959	gi	PTHR11961:SF9	CYTOCHROME C-1-RELATED
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00005	Angiogenesis	P00231	HSP27	ANOGA|EnsemblGenome=AGAP007161|UniProtKB=Q7PT52	AGAP007161-PA	ISS			PTHR11527:SF252	HEAT SHOCK PROTEIN BETA-11
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00036	Interleukin signaling pathway	P00968	Ikk	MOUSE|MGI=MGI=99484|UniProtKB=Q60680	Inhibitor of nuclear factor kappa-B kinase subunit alpha	ISS	9346484	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P02723	Adenine and hypoxanthine salvage pathway	P02813	Inosine phosphorylase	YEAST|SGD=S000004199|UniProtKB=Q05788	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00001	Adrenaline and noradrenaline biosynthesis	P00066	DOPA decarb.	PANTR|Ensembl=ENSPTRG00000019189|UniProtKB=H2QUK8	Uncharacterized protein	ISS	7567987	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05918	p38 MAPK pathway	P06031	p38alpha	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05752	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	XENTR|Xenbase=XB-GENE-478850|UniProtKB=F6SV95	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF69	ACTIVIN RECEPTOR TYPE-1
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MOUSE|MGI=MGI=95822|UniProtKB=Q01098	Glutamate receptor ionotropic, NMDA 2C	IC	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00057	Wnt signaling pathway	P01457	GBeta	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P02749	Leucine biosynthesis	P03000	Branched chain amino acid aminotransferase	MYCTU|EnsemblGenome=Rv2210c|UniProtKB=P9WQ75	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF44	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P04393	Ras Pathway	P04541	p90RSK	MONDO|Ensembl=ENSMODG00000008086|UniProtKB=F6YJ34	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	TAKRU|Ensembl=ENSTRUG00000015213|UniProtKB=H2UPJ1	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF356	SUBFAMILY NOT NAMED
P00059	p53 pathway	P04619	HMG1	CHICK|Ensembl=ENSGALG00000017082|UniProtKB=Q9YH06	High mobility group protein B1	ISS			PTHR13711:SF164	HIGH MOBILITY GROUP PROTEIN B1-RELATED
P00030	Hypoxia response via HIF activation	P00824	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00005	Angiogenesis	P00256	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	MOUSE|MGI=MGI=109523|UniProtKB=Q61143	Short transient receptor potential channel 6	IDA	11055438	PubMed	PTHR10117:SF7	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00852	PYK2	HUMAN|HGNC=9612|UniProtKB=Q14289	Protein-tyrosine kinase 2-beta	ISS	12640026	PubMed	PTHR24418:SF94	PROTEIN-TYROSINE KINASE 2-BETA
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IGI	8132661	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P02738	De novo purine biosynthesis	P02907	dADP kinase	PYRAE|EnsemblGenome=PAE1561|UniProtKB=Q8ZWY4	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00805	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01322	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01026	KA	RAT|RGD=2733|UniProtKB=P42260	Glutamate receptor ionotropic, kainate 2	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000001713|UniProtKB=F7FZG1	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF84	CADHERIN-20
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00996	STAT	HUMAN|HGNC=11364|UniProtKB=P40763	Signal transducer and activator of transcription 3	IC	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	MACMU|Ensembl=ENSMMUG00000012005|UniProtKB=F7H091	Metabotropic glutamate receptor 2 isoform a	ISS	12351712	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P02746	Heme biosynthesis	P02970	Coproporphyrinogen oxidase (oxygen independent)	MOUSE|MGI=MGI=3039628|UniProtKB=Q5SUV1	Radical S-adenosyl methionine domain-containing protein 1, mitochondrial	ISS			PTHR13932:SF14	RADICAL S-ADENOSYL METHIONINE DOMAIN-CONTAINING PROTEIN 1, MITOCHONDRIAL
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	STRPU|EnsemblGenome=SPU_014966|UniProtKB=W4YGS7	Uncharacterized protein	ISS			PTHR23073:SF31	26S PROTEASE REGULATORY SUBUNIT 10B
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00012	Cadherin signaling pathway	P00462	Casein kinase II	DAPPU|EnsemblGenome=DAPPUDRAFT_305830|UniProtKB=E9GTE8	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01136	Elk-1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	TAS	11279280	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT1G10210|UniProtKB=Q39021	Mitogen-activated protein kinase 1	ISS	10851062	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MONDO|Ensembl=ENSMODG00000013214|UniProtKB=F7EVX9	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF29	72 KDA TYPE IV COLLAGENASE
P00049	Parkinson disease	P01219	SAPK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00053	T cell activation	P01332	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00045	Notch signaling pathway	P01110	Presenilin	HUMAN|HGNC=9508|UniProtKB=P49768	Presenilin-1	IDA	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00030	Hypoxia response via HIF activation	P00819	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	TAS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01286	TGFbeta	DANRE|ZFIN=ZDB-GENE-030723-3|UniProtKB=F8W4A6	Uncharacterized protein (Fragment)	ISS	9759503	PubMed	PTHR11848:SF141	TRANSFORMING GROWTH FACTOR BETA-2
P00021	FGF signaling pathway	P00641	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04398	p53 pathway feedback loops 2	G04714	PTEN	DROME|FlyBase=FBgn0026379|UniProtKB=Q7KMQ6	IP16020p	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P02771	Pyrimidine Metabolism	P03124	Methylmalonate Semialdehyde Dehydrogenase	RAT|RGD=621556|UniProtKB=Q02253	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	NAS	2708830	gi	PTHR43866:SF3	METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE  ACYLATING , MITOCHONDRIAL
P00019	Endothelin signaling pathway	P00590	IP3 R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IGI	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00006	Apoptosis signaling pathway	P00277	Bi1	BOVIN|Ensembl=ENSBTAG00000018588|UniProtKB=Q0V882	Bax inhibitor 1	ISS			PTHR23291:SF34	BAX INHIBITOR 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00011	Blood coagulation	P00456	HCII	RAT|RGD=619854|UniProtKB=Q64268	Heparin cofactor 2	ISS	6680183	gi	PTHR11461:SF30	HEPARIN COFACTOR 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P06959	CCKR signaling map	G07276	JUN	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	RCA	17185632	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00053	T cell activation	P01319	PAK	BOVIN|Ensembl=ENSBTAG00000015670|UniProtKB=E1B7J7	Uncharacterized protein	ISS	11259591	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P05731	GABA-B receptor II signaling	P05752	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	RCA	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00036	Interleukin signaling pathway	P00968	Ikk	BOVIN|Ensembl=ENSBTAG00000007591|UniProtKB=Q95KV1	Inhibitor of nuclear factor kappa-B kinase subunit alpha	ISS	12813046	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02920	dCTP deaminase	MACMU|Ensembl=ENSMMUG00000005362|UniProtKB=F7GAS0	Uncharacterized protein	ISS			PTHR11079:SF92	TRNA-SPECIFIC ADENOSINE DEAMINASE 2
P00018	EGF receptor signaling pathway	P00564	Rac	DICDI|dictyBase=DDB_G0286555|UniProtKB=P34147	Rho-related protein racA	IGI	94124042	PubMed	PTHR24072:SF183	RHO-RELATED PROTEIN RACA
P00005	Angiogenesis	P00252	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8617307	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IDA	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=98957|UniProtKB=P22724	Protein Wnt-4	IDA	8717036	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04674	Mdm2	MOUSE|MGI=MGI=107934|UniProtKB=O35618	Protein Mdm4	ISS			PTHR13844:SF20	PROTEIN MDM4
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	CANLF|Ensembl=ENSCAFG00000009588|UniProtKB=E2RNA9	Uncharacterized protein	RCA			PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00920	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	MACMU|Ensembl=ENSMMUG00000009820|UniProtKB=F6WZT0	Uncharacterized protein	ISS	11055438	PubMed	PTHR10117:SF8	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	PANTR|Gene=CHRNA5|UniProtKB=Q5IS51	Neuronal acetylcholine receptor subunit alpha-5	ISS	12388584	PubMed	PTHR18945:SF76	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5
P00034	Integrin signalling pathway	P00913	Csk	PANTR|Ensembl=ENSPTRG00000007282|UniProtKB=H2Q9T1	Tyrosine-protein kinase	ISS	7687537	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01150	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	MACMU|Ensembl=ENSMMUG00000015276|UniProtKB=F7DUK6	Uncharacterized protein	ISS	1370475	PubMed	PTHR44087:SF1	PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, SKELETAL MUSCLE/HEART ISOFORM
P00046	Oxidative stress response	P01135	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	ANOGA|EnsemblGenome=AGAP001478|UniProtKB=Q7PXM3	AGAP001478-PA	IC	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P02775	Salvage pyrimidine ribonucleotides	P03149	Cytidine kinase	ARATH|TAIR=AT5G40870|UniProtKB=Q9FKS0	Uridine kinase-like protein 1, chloroplastic	ISS			PTHR10285:SF70	URIDINE-CYTIDINE KINASE 2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05918	p38 MAPK pathway	P06034	MKK4	CHICK|Ensembl=ENSGALG00000001001|UniProtKB=F1P3T1	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00053	T cell activation	P01336	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	BOVIN|Gene=ADCY1|UniProtKB=P19754	Adenylate cyclase type 1	IGI	89298382	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P00005	Angiogenesis	P00189	Fzd	RAT|RGD=61916|UniProtKB=Q08463	Frizzled-1	ISS	11212302	PubMed	PTHR11309:SF81	FRIZZLED-1
P00047	PDGF signaling pathway	P01150	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00046	Oxidative stress response	P01131	MKP5	BOVIN|Ensembl=ENSBTAG00000020350|UniProtKB=F1MP34	Dual specificity protein phosphatase	ISS			PTHR10159:SF109	DUAL SPECIFICITY PROTEIN PHOSPHATASE 2
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	HUMAN|HGNC=18856|UniProtKB=Q96BA8	Cyclic AMP-responsive element-binding protein 3-like protein 1	ISS	123810	OMIM	PTHR22952:SF24	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00013	Cell cycle	P00480	Proteasome	CANLF|Ensembl=ENSCAFG00000011453|UniProtKB=J9JHD9	Uncharacterized protein	ISS	12477932	PubMed	PTHR10855:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00004	Alzheimer disease-presenilin pathway	P00170	Aph-1	MOUSE|MGI=MGI=3522097|UniProtKB=Q8C7N7	Gamma-secretase subunit APH-1B	IDA	12110170	PubMed	PTHR12889:SF1	GAMMA-SECRETASE SUBUNIT APH-1B
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P06959	CCKR signaling map	G07266	FOS	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	RCA	17185632	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IDA	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	BOVIN|Ensembl=ENSBTAG00000013066|UniProtKB=P07456	Insulin-like growth factor II	ISS	4504609	gi	PTHR11454:SF10	INSULIN-LIKE GROWTH FACTOR II
P05912	Dopamine receptor mediated signaling pathway	P05945	Gsalpha	CHICK|Ensembl=ENSGALG00000007509|UniProtKB=F1NM72	Uncharacterized protein	ISS	87005246	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	RAT|RGD=1597195|UniProtKB=D4A9J2	Protein Wnt	ISS	14644163	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	IGI	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00021	FGF signaling pathway	P00636	FGFR1-4	PANTR|Ensembl=ENSPTRG00000003003|UniProtKB=H2Q2P3	Fibroblast growth factor receptor	ISS	1373495	PubMed	PTHR24416:SF130	FIBROBLAST GROWTH FACTOR RECEPTOR 2
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00036	Interleukin signaling pathway	P00970	Interleukin	PANTR|Ensembl=ENSPTRG00000018979|UniProtKB=H2QU89	Interleukin 6 (Interferon, beta 2)	ISS			PTHR45110:SF1	INTERLEUKIN-6
P02762	Pentose phosphate pathway	P03070	Gluconate Dehydrogenase	MONDO|Ensembl=ENSMODG00000002668|UniProtKB=F7DHT9	6-phosphogluconate dehydrogenase, decarboxylating	ISS	8978909	PubMed	PTHR11811:SF25	6-PHOSPHOGLUCONATE DEHYDROGENASE, DECARBOXYLATING
P02746	Heme biosynthesis	P02983	Hydroxymethylbilane synthase	AQUAE|EnsemblGenome=aq_263|UniProtKB=O66621	Porphobilinogen deaminase	ISS			PTHR11557:SF0	PORPHOBILINOGEN DEAMINASE
P00012	Cadherin signaling pathway	P00465	TCF/LEF	PANTR|Ensembl=ENSPTRG00000016352|UniProtKB=H2QQ05	Uncharacterized protein	ISS	9039917	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00021	FGF signaling pathway	P00643	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01428	Frizzled	XENTR|Xenbase=XB-GENE-487022|UniProtKB=F6SH04	Uncharacterized protein (Fragment)	ISS	8717036	PubMed	PTHR11309:SF34	FRIZZLED-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	IDA	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00645	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	8649368	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P02738	De novo purine biosynthesis	P02909	GDP reductase	CHLTR|EnsemblGenome=CT_827|UniProtKB=O84834	Ribonucleoside-diphosphate reductase subunit alpha	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	XENTR|Xenbase=XB-GENE-981938|UniProtKB=F6X2C1	Uncharacterized protein	ISS			PTHR11964:SF12	S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2
P00006	Apoptosis signaling pathway	P00269	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01332	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00059	p53 pathway	P04623	CBP	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00034	Integrin signalling pathway	P00944	Actin	BOVIN|Ensembl=ENSBTAG00000006189|UniProtKB=P63258	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00018	EGF receptor signaling pathway	P00564	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00009	Axon guidance mediated by netrin	P00356	UNC-5	RAT|RGD=1309245|UniProtKB=F1LW30	Netrin receptor UNC5D	ISS			PTHR12582:SF5	NETRIN RECEPTOR UNC5D
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TAKRU|Ensembl=ENSTRUG00000004787|UniProtKB=P53480	Actin, alpha cardiac	IC	11889139	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	IDA	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	STRPU|EnsemblGenome=SPU_012282|UniProtKB=W4Y969	Uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF369	ACTIN-42A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00010	B cell activation	P00385	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	20264070	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00054	Toll receptor signaling pathway	P01346	TLR	MACMU|Ensembl=ENSMMUG00000021762|UniProtKB=F7DWP4	Uncharacterized protein	ISS			PTHR44599:SF1	TOLL-LIKE RECEPTOR 3
P00005	Angiogenesis	P00215	Nck	MOUSE|MGI=MGI=1306821|UniProtKB=O55033	Cytoplasmic protein NCK2	ISS	12874226	PubMed	PTHR44108:SF1	CYTOPLASMIC PROTEIN NCK2
P00057	Wnt signaling pathway	P01456	beta-arrestin	HUMAN|HGNC=711|UniProtKB=P49407	Beta-arrestin-1	IDA	9388255	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P06664	Gonadotropin-releasing hormone receptor pathway	P06831	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	RCA	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00047	PDGF signaling pathway	P01155	Jak	MACMU|Ensembl=ENSMMUG00000018566|UniProtKB=F6YLX1	Tyrosine-protein kinase	ISS	11929133	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P05731	GABA-B receptor II signaling	P05754	Ggamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	MACMU|Ensembl=ENSMMUG00000007096|UniProtKB=F7ERG6	G protein-activated inward rectifier potassium channel 1	ISS	12374786	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00018	EGF receptor signaling pathway	P00547	PP2A	MONDO|Ensembl=ENSMODG00000014177|UniProtKB=F6U7A6	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	TRYB2|Gene=Tb10.70.3710|UniProtKB=Q38BN3	Aspartate aminotransferase	ISS			PTHR11879:SF22	ASPARTATE AMINOTRANSFERASE
P04393	Ras Pathway	P04558	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=3710243|UniProtKB=A2AQP0	Myosin-7B	ISS	89264452	PubMed	PTHR13140:SF358	MYOSIN-7B
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00005	Angiogenesis	P00254	GTPase	CHICK|Ensembl=ENSGALG00000003806|UniProtKB=O93467	GTP-binding protein	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MOUSE|MGI=MGI=1915021|UniProtKB=Q9CPW4	Actin-related protein 2/3 complex subunit 5	ISS	10322212	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	IDA	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00056	VEGF signaling pathway	P01401	HIF-1	CANLF|Ensembl=ENSCAFG00000015718|UniProtKB=F1PZ54	Uncharacterized protein	ISS	14526383	PubMed	PTHR23043:SF7	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00627	ERK1-2	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00807	Actin	XENTR|Xenbase=XB-GENE-6469705|UniProtKB=Q6P8G3	Actin, alpha sarcomeric/skeletal	ISS	11889139	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00059	p53 pathway	P04635	Sumo-1 ligase	XENTR|Xenbase=XB-GENE-969139|UniProtKB=Q28H04	Small ubiquitin-related modifier 2	ISS			PTHR10562:SF11	SMALL UBIQUITIN-RELATED MODIFIER 2-RELATED
P00049	Parkinson disease	P01236	Casein kinase II	MONDO|Ensembl=ENSMODG00000014080|UniProtKB=F6R511	Uncharacterized protein (Fragment)	ISS	10617630	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P04398	p53 pathway feedback loops 2	P04661	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	ISS	12660731	PubMed	PTHR10048:SF14	PI-3 KINASE
P04393	Ras Pathway	P04579	Shc	MOUSE|MGI=MGI=98296|UniProtKB=P98083	SHC-transforming protein 1	IDA	95096035	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01154	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00053	T cell activation	P01336	Jnk	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00059	p53 pathway	P04630	PP2A	MOUSE|MGI=MGI=1321161|UniProtKB=P62715	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00586	Gq	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00551	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01193	IRS	DROME|FlyBase=FBgn0024248|UniProtKB=Q9XTN2	Insulin receptor substrate 1	IGI	15175753	PubMed	PTHR10614:SF13	INSULIN RECEPTOR SUBSTRATE 1
P00019	Endothelin signaling pathway	P00572	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00942	Fyn	BOVIN|Ensembl=ENSBTAG00000011851|UniProtKB=A0JNB0	Tyrosine-protein kinase Fyn	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00029	Huntington disease	P00805	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P06959	CCKR signaling map	P07158	NOS1	HUMAN|HGNC=7872|UniProtKB=P29475	Nitric oxide synthase, brain	RCA	16984226	PubMed	PTHR19384:SF63	NITRIC OXIDE SYNTHASE, BRAIN
P00047	PDGF signaling pathway	P01143	ERK	RAT|RGD=62087|UniProtKB=P27704	Mitogen-activated protein kinase 6	ISS	8444355	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00060	Ubiquitin proteasome pathway	P01492	E1	BOVIN|Ensembl=ENSBTAG00000035827|UniProtKB=E1BNN7	Uncharacterized protein	ISS			PTHR10953:SF3	UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04393	Ras Pathway	P04556	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IDA	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00235	c-Fos	TAKRU|Ensembl=ENSTRUG00000018314|UniProtKB=H2VCA7	Uncharacterized protein (Fragment)	ISS			PTHR23351:SF22	SUBFAMILY NOT NAMED
P00049	Parkinson disease	P01211	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IGI	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00021	FGF signaling pathway	P00645	Rac	DROME|FlyBase=FBgn0010333|UniProtKB=P40792	Ras-related protein Rac1	IGI	4757952	gi	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00057	Wnt signaling pathway	P01472	Histone deacetylase	CHICK|Ensembl=ENSGALG00000003297|UniProtKB=P56517	Histone deacetylase 1	IDA	12665570	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P05731	GABA-B receptor II signaling	P05752	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05731	GABA-B receptor II signaling	P05760	AC	RAT|RGD=71014|UniProtKB=Q04400	Adenylate cyclase type 5	RCA	1409703	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00049	Parkinson disease	P01236	Casein kinase II	NEUCR|EnsemblGenome=EFNCRG00000001945|UniProtKB=Q8TG11	Casein kinase II subunit beta-2	IDA	10806215	PubMed	PTHR22746:SF10	RAB6A-GEF COMPLEX PARTNER PROTEIN 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	IPI	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	BOVIN|Ensembl=ENSBTAG00000016341|UniProtKB=Q3T0T8	Regulator of G-protein signaling 5	ISS	8756726	PubMed	PTHR10845:SF42	REGULATOR OF G-PROTEIN SIGNALING 5
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	RAT|RGD=2869|UniProtKB=P24062	Insulin-like growth factor 1 receptor	ISS	6754360	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00010	B cell activation	P00398	IP3R	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	IGI	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00018	EGF receptor signaling pathway	P00564	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	20264070	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00012	Cadherin signaling pathway	P00464	Fyn	RAT|RGD=2641|UniProtKB=Q62844	Tyrosine-protein kinase Fyn	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00048	PI3 kinase pathway	P01192	p110	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00011	Blood coagulation	P00411	PAI-1	RAT|RGD=3249|UniProtKB=P20961	Plasminogen activator inhibitor 1	ISS	10692390	PubMed	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_58093|UniProtKB=C3Z4K3	Putative uncharacterized protein	IDA	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00010	B cell activation	P00385	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00034	Integrin signalling pathway	P00931	Integrin beta	MOUSE|MGI=MGI=96612|UniProtKB=O54890	Integrin beta-3	IDA	5805343	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00023	General transcription regulation	P00658	TBP-associated factors	DROME|FlyBase=FBgn0014342|UniProtKB=Q9VND0	Meiosis I arrest, isoform A	ISS			PTHR10221:SF12	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6
P00006	Apoptosis signaling pathway	P00265	Granzyme B	MOUSE|MGI=MGI=109267|UniProtKB=P04187	Granzyme B(G,H)	IDA	12648450	PubMed	PTHR24271:SF41	GRANZYME B
P00018	EGF receptor signaling pathway	P00561	STAT	PANTR|Ensembl=ENSPTRG00000009200|UniProtKB=H2QD20	Signal transducer and activator of transcription	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	PANTR|Ensembl=ENSPTRG00000019161|UniProtKB=H2QUJ4	Uncharacterized protein	ISS	89298382	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P00021	FGF signaling pathway	P00644	p38	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00018	EGF receptor signaling pathway	P00562	p38	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	BOVIN|Ensembl=ENSBTAG00000018373|UniProtKB=O02675	Dihydropyrimidinase-related protein 2	TAS	Q90635	SPACC	PTHR11647:SF56	DIHYDROPYRIMIDINASE-RELATED PROTEIN 2
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00005	Angiogenesis	P00203	Erk	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00056	VEGF signaling pathway	P01418	Paxillin	PANTR|Ensembl=ENSPTRG00000005527|UniProtKB=H2Q704	Paxillin	ISS	9182576	PubMed	PTHR24216:SF11	PAXILLIN
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	RAT|RGD=3187|UniProtKB=Q07008	Neurogenic locus notch homolog protein 1	IDA	1764995	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	RAT|RGD=1307644|UniProtKB=D3ZND6	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00054	Toll receptor signaling pathway	P01375	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MOUSE|MGI=MGI=1339711|UniProtKB=Q5SX40	Myosin-1	IEP	10938134	PubMed	PTHR13140:SF484	MYOSIN-1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04393	Ras Pathway	P04541	p90RSK	HUMAN|HGNC=10432|UniProtKB=P51812	Ribosomal protein S6 kinase alpha-3	IDA	10480933	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00045	Notch signaling pathway	P01110	Presenilin	MACMU|Ensembl=ENSMMUG00000010173|UniProtKB=F7AGU8	Presenilin	ISS	12736250	PubMed	PTHR10202:SF18	PRESENILIN-1
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	XENTR|Xenbase=XB-GENE-494200|UniProtKB=F7CS79	Uncharacterized protein	ISS	11554554	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000022175|UniProtKB=F6XHY0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00019	Endothelin signaling pathway	P00568	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04572	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04572	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IDA	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00019	Endothelin signaling pathway	P00566	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00018	EGF receptor signaling pathway	P00557	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00049	Parkinson disease	P01211	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05918	p38 MAPK pathway	P06015	p38gamma	DANRE|ZFIN=ZDB-GENE-990415-257|UniProtKB=O42376	Mitogen-activated protein kinase 12	ISS	10514528	PubMed	PTHR24055:SF339	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00047	PDGF signaling pathway	P01147	Nck	CHICK|Ensembl=ENSGALG00000016799|UniProtKB=F1P4Q4	Uncharacterized protein	ISS	12874226	PubMed	PTHR44108:SF1	CYTOPLASMIC PROTEIN NCK2
P00045	Notch signaling pathway	P01103	Next	PANTR|Ensembl=ENSPTRG00000013250|UniProtKB=H2QJZ0	Delta-like protein	ISS	10551863	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MOUSE|MGI=MGI=2150393|UniProtKB=Q91ZU9	Glutamate receptor ionotropic, NMDA 3B	ISS	11319238	PubMed	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00010	B cell activation	P00391	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	CHICK|Gene=KCNJ3|UniProtKB=Q90854	G protein-activated inward rectifier potassium channel 1	IDA	2433589	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04393	Ras Pathway	P04552	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IDA	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00036	Interleukin signaling pathway	P00983	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01043	AC	PANTR|Ensembl=ENSPTRG00000001638|UniProtKB=H2Q0J3	Adenylate cyclase type 10	ISS	9874775	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P00059	p53 pathway	P04633	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00054	Toll receptor signaling pathway	P01369	MKK1	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04454	CRF	BOVIN|Ensembl=ENSBTAG00000033128|UniProtKB=Q95MI6	Corticoliberin	ISS	122560	OMIM	PTHR15035:SF9	CORTICOLIBERIN
P00034	Integrin signalling pathway	P00916	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P05731	GABA-B receptor II signaling	P05755	Gbeta	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00020	FAS signaling pathway	P00615	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IDA	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00030	Hypoxia response via HIF activation	P00819	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	PANTR|Ensembl=ENSPTRG00000010386|UniProtKB=H2QF61	Tyrosine-protein kinase receptor	ISS	2983222	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01447	Dishevelled	RAT|RGD=620632|UniProtKB=Q9WVB9	Segment polarity protein dishevelled homolog DVL-1	ISS	12549854	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P00057	Wnt signaling pathway	P01444	Wnt	PANTR|Ensembl=ENSPTRG00000002849|UniProtKB=H2Q2F4	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00018	EGF receptor signaling pathway	P00539	14-3-3	ANOGA|EnsemblGenome=AGAP007643|UniProtKB=A0NBC2	AGAP007643-PA	ISS	10407019	PubMed	PTHR18860:SF13	14-3-3 PROTEIN ZETA
P00029	Huntington disease	P00768	Apaf-1	DANRE|ZFIN=ZDB-GENE-000616-4|UniProtKB=Q9I9H8	Apoptotic protease-activating factor 1	TAS	14526190	PubMed	PTHR22845:SF5	APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Ensembl=ENSCAFG00000010787|UniProtKB=E2R3W6	Uncharacterized protein	ISS	1319557	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00018	EGF receptor signaling pathway	P00561	STAT	MONDO|Ensembl=ENSMODG00000014836|UniProtKB=F7D2D3	Signal transducer and activator of transcription	ISS	22320921	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P02723	Adenine and hypoxanthine salvage pathway	P02809	Xanthine dehydrogenase	ARATH|TAIR=AT4G34890|UniProtKB=Q8GUQ8	Xanthine dehydrogenase 1	ISS			PTHR11908:SF100	XANTHINE DEHYDROGENASE
P00006	Apoptosis signaling pathway	P00260	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00058	mRNA splicing	P01473	U6	ARATH|TAIR=AT2G05720|UniProtKB=Q9SIB8	Putative U4/U6 small nuclear ribonucleoprotein	ISS			PTHR19846:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP4
P00053	T cell activation	P01313	CD28	PANTR|Ensembl=ENSPTRG00000012833|UniProtKB=H2QJ99	Uncharacterized protein	ISS	7534617	PubMed	PTHR11494:SF7	T-CELL-SPECIFIC SURFACE GLYCOPROTEIN CD28
P00019	Endothelin signaling pathway	P00574	Big ET1-4	DANRE|ZFIN=ZDB-GENE-000920-1|UniProtKB=A5WW41	Uncharacterized protein	IGI	15117818	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	87218499	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04398	p53 pathway feedback loops 2	P04651	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	BOVIN|Ensembl=ENSBTAG00000009835|UniProtKB=F1MR37	Uncharacterized protein	ISS	14526084	PubMed	PTHR10037:SF137	VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1G
P04393	Ras Pathway	P04570	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00547	PP2A	MONDO|Ensembl=ENSMODG00000019001|UniProtKB=F7CP86	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00640	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IGI	1171954	gi	PTHR10048:SF14	PI-3 KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	CANLF|Ensembl=ENSCAFG00000004930|UniProtKB=E2RFB5	Uncharacterized protein	ISS	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MOUSE|MGI=MGI=95779|UniProtKB=P50149	Guanine nucleotide-binding protein G(t) subunit alpha-2	ISS	10188796	PubMed	PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00047	PDGF signaling pathway	P01152	RasGAP	HUMAN|HGNC=35202|UniProtKB=C9J798	Ras GTPase-activating protein 4B	ISS	6635197	gi	PTHR10194:SF4	RAS GTPASE-ACTIVATING PROTEIN 4-RELATED
P04393	Ras Pathway	P04570	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00053	T cell activation	P01312	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	HUMAN|HGNC=6698|UniProtKB=O75581	Low-density lipoprotein receptor-related protein 6	IDA	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P04393	Ras Pathway	P04557	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	TAKRU|Ensembl=ENSTRUG00000016101|UniProtKB=H2UW32	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00021	FGF signaling pathway	P00647	SHP2	CHICK|Ensembl=ENSGALG00000004821|UniProtKB=Q90687	Tyrosine-protein phosphatase non-receptor type 11	ISS	1382983	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00006	Apoptosis signaling pathway	P00260	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00050	Plasminogen activating cascade	P01262	pro-uPA	BOVIN|Ensembl=ENSBTAG00000005947|UniProtKB=Q05589	Urokinase-type plasminogen activator	ISS	465014	gi	PTHR24264:SF38	UROKINASE-TYPE PLASMINOGEN ACTIVATOR
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00017	DNA replication	P00527	Histones	STRPU|GeneID=373340|UniProtKB=P06352	Histone H3, embryonic	ISS	12413958	PubMed	PTHR11426:SF20	HISTONE H3-LIKE CENTROMERIC PROTEIN A
P00037	Ionotropic glutamate receptor pathway	P01026	KA	RAT|RGD=2732|UniProtKB=P22756	Glutamate receptor ionotropic, kainate 1	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00018	EGF receptor signaling pathway	P00564	Rac	DICDI|dictyBase=DDB_G0293526|UniProtKB=P34149	Rho-related protein racC	IGI	8649368	PubMed	PTHR24072:SF117	RHO-RELATED PROTEIN RACC
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IC	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	MOUSE|MGI=MGI=97852|UniProtKB=P62835	Ras-related protein Rap-1A	ISS	1904317	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00021	FGF signaling pathway	P00623	FGF	PANTR|Ensembl=ENSPTRG00000004552|UniProtKB=H2Q587	Fibroblast growth factor	ISS			PTHR11486:SF25	FIBROBLAST GROWTH FACTOR 6
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00018	EGF receptor signaling pathway	P00561	STAT	MONDO|Ensembl=ENSMODG00000014836|UniProtKB=F7D2D3	Signal transducer and activator of transcription	ISS	96210005	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04393	Ras Pathway	P04541	p90RSK	PANTR|Ensembl=ENSPTRG00000022064|UniProtKB=H2QYE0	Uncharacterized protein	ISS	6755374	gi	PTHR24351:SF98	RIBOSOMAL PROTEIN S6 KINASE ALPHA-6
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000022175|UniProtKB=F6XHY0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	PANTR|Ensembl=ENSPTRG00000012508|UniProtKB=H2QIS5	Uncharacterized protein	ISS	11907044	PubMed	PTHR44025:SF7	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B
P00047	PDGF signaling pathway	P01168	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	7937853	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00010	B cell activation	P00379	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	HUMAN|HGNC=1388|UniProtKB=O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	14507926	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00047	PDGF signaling pathway	P01164	PDK1/2	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	15210700	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00021	FGF signaling pathway	P00629	PP2A	PANTR|Ensembl=ENSPTRG00000018180|UniProtKB=H2QT14	Protein phosphatase 2, regulatory subunit B', delta	ISS	96161994	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00029	Huntington disease	P00796	Kainate receptor	RAT|RGD=2734|UniProtKB=Q01812	Glutamate receptor ionotropic, kainate 4	IDA	12778120	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P02721	ATP synthesis	P02791	F1 alpha	MACMU|Ensembl=ENSMMUG00000003570|UniProtKB=F7ETD0	ATP synthase subunit alpha	ISS	2527557	PubMed	PTHR43089:SF4	ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00021	FGF signaling pathway	P00642	MEK1-2	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MONDO|Ensembl=ENSMODG00000018204|UniProtKB=F6PGX6	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00057	Wnt signaling pathway	P01468	APC	MOUSE|MGI=MGI=88039|UniProtKB=Q61315	Adenomatous polyposis coli protein	IDA	8259518	PubMed	PTHR12607:SF11	ADENOMATOUS POLYPOSIS COLI PROTEIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00551	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEEL|WormBase=WBGene00004033|UniProtKB=P90980	Protein kinase C-like 2	ISS	15572354	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00054	Toll receptor signaling pathway	P01373	CD14	PANTR|Ensembl=ENSPTRG00000028584|UniProtKB=H2R5A8	Monocyte differentiation antigen CD14	ISS			PTHR10630:SF3	MONOCYTE DIFFERENTIATION ANTIGEN CD14
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00015	Circadian clock system	G01501	cry	MACMU|Ensembl=ENSMMUG00000002453|UniProtKB=F7HH05	Cryptochrome-2	ISS	11804325	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00005	Angiogenesis	P00189	Fzd	BOVIN|Ensembl=ENSBTAG00000020590|UniProtKB=G3N2W8	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF34	FRIZZLED-2
P00005	Angiogenesis	P00224	PDGF	RAT|RGD=68410|UniProtKB=Q9EQX6	Platelet-derived growth factor C	ISS			PTHR11633:SF5	PLATELET-DERIVED GROWTH FACTOR C
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	PANTR|Ensembl=ENSPTRG00000023062|UniProtKB=H2R2U1	Catenin (Cadherin-associated protein), beta 1, 88kDa	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00035	Interferon-gamma signaling pathway	P00956	SOCS	PANTR|Ensembl=ENSPTRG00000009709|UniProtKB=H2QDZ6	Suppressor of cytokine signaling 3	ISS	15032587	PubMed	PTHR44534:SF3	SUPPRESSOR OF CYTOKINE SIGNALING 3
P00010	B cell activation	P00386	Calcineurin	PANTR|Ensembl=ENSPTRG00000002631|UniProtKB=H2Q237	Serine/threonine-protein phosphatase	ISS	12015605	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00038	JAK/STAT signaling pathway	P01034	Jak	PANTR|Ensembl=ENSPTRG00000020744|UniProtKB=H2QWZ4	Tyrosine-protein kinase	ISS	22482294	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P06959	CCKR signaling map	G07262	HDC	HUMAN|HGNC=4855|UniProtKB=P19113	Histidine decarboxylase	RCA	8662934	PubMed	PTHR11999:SF68	HISTIDINE DECARBOXYLASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04393	Ras Pathway	P04546	GSK3	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01142	p90RSK	MOUSE|MGI=MGI=1930076|UniProtKB=Q9Z2B9	Ribosomal protein S6 kinase alpha-4	ISS	9792677	PubMed	PTHR24351:SF41	RIBOSOMAL PROTEIN S6 KINASE ALPHA-4
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04552	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=12785|UniProtKB=Q9Y6F9	Protein Wnt-6	TAS	11266476	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P00010	B cell activation	P00383	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05916	Opioid prodynorphin pathway	P06002	G-protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	12810719	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	RAT|RGD=2738|UniProtKB=Q00960	Glutamate receptor ionotropic, NMDA 2B	IC	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00056	VEGF signaling pathway	P01414	PLC-gamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04393	Ras Pathway	P04558	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00047	PDGF signaling pathway	P01154	Ras	DICDI|dictyBase=DDB_G0292996|UniProtKB=P03967	Ras-like protein rasD	ISS	6091907	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00059	p53 pathway	P01485	p53	MOUSE|MGI=MGI=98834|UniProtKB=P02340	Cellular tumor antigen p53	TAS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	CANLF|Ensembl=ENSCAFG00000015662|UniProtKB=E2RHY4	Uncharacterized protein	ISS	10051575	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04398	p53 pathway feedback loops 2	P04657	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000014828|UniProtKB=F1N1E0	Uncharacterized protein	ISS	8386525	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	ANOGA|EnsemblGenome=AGAP010957|UniProtKB=Q7QGY7	AGAP010957-PA (Fragment)	ISS	10487978	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00021	FGF signaling pathway	P00632	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IGI	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=1930705|UniProtKB=P61264	Syntaxin-1B	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00014	Cholesterol biosynthesis	P00494	Squalene monooxygenas	LEIMA|EnsemblGenome=LmjF.13.1620|UniProtKB=Q4QFZ2	Squalene monooxygenase-like protein	ISS			PTHR10835:SF0	SQUALENE MONOOXYGENASE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00053	T cell activation	P01300	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00020	FAS signaling pathway	P00612	Fas	HUMAN|HGNC=11920|UniProtKB=P25445	Tumor necrosis factor receptor superfamily member 6	TAS	1375228	PubMed	PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P02723	Adenine and hypoxanthine salvage pathway	P02809	Xanthine dehydrogenase	PANTR|Ensembl=ENSPTRG00000011806|UniProtKB=H2QHQ2	Uncharacterized protein	ISS	8708081	PubMed	PTHR11908:SF80	XANTHINE DEHYDROGENASE/OXIDASE
P00006	Apoptosis signaling pathway	P00260	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000024633|UniProtKB=F1MBU9	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00055	Transcription regulation by bZIP transcription factor	P01398	TFIIEalpha	MACMU|Ensembl=ENSMMUG00000001596|UniProtKB=F7GV34	General transcription factor IIE subunit 1	ISS	189962	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=1339710|UniProtKB=G3UW82	MCG140437, isoform CRA_d	IC	10938134	PubMed	PTHR13140:SF385	MYOSIN-2
P02740	De novo pyrimidine ribonucleotides biosythesis	P02930	Orotidine-5-phosphate decarboxylase	METAC|EnsemblGenome=MA_0969|UniProtKB=Q8TS37	Orotidine 5'-phosphate decarboxylase	ISS			PTHR19278:SF9	URIDINE 5'-MONOPHOSPHATE SYNTHASE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00005	Angiogenesis	P00256	PLC-gamma	CAEEL|WormBase=WBGene00004038|UniProtKB=Q22070	Phosphoinositide phospholipase C	ISS			PTHR10336:SF91	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000022936|UniProtKB=F6U709	Uncharacterized protein	ISS	11248120	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	CAEEL|WormBase=WBGene00004391|UniProtKB=Q03604	Ribonucleoside-diphosphate reductase large subunit	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00053	T cell activation	P01330	IKK	RAT|RGD=621375|UniProtKB=Q9QY78	Inhibitor of nuclear factor kappa-B kinase subunit beta	IGI	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05913	Enkephalin release	P05977	G-Protein (s)	TAKRU|Ensembl=ENSTRUG00000010005|UniProtKB=H2TKG8	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P02757	O-antigen biosynthesis	P03050	dTDP-4-dehydrorhamnose reductase	BOVIN|Ensembl=ENSBTAG00000012350|UniProtKB=Q29RI9	Methionine adenosyltransferase 2 subunit beta	ISS			PTHR10491:SF4	METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IDA	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00034	Integrin signalling pathway	P00924	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06764	Jund	MOUSE|MGI=MGI=96648|UniProtKB=P15066	Transcription factor jun-D	RCA	10664585	PubMed	PTHR11462:SF7	TRANSCRIPTION FACTOR JUN-D
P00059	p53 pathway	P04612	HDAC1	DANRE|ZFIN=ZDB-GENE-020419-32|UniProtKB=F1R653	Histone deacetylase	ISS	10485845	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	7937853	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00006	Apoptosis signaling pathway	P00274	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00049	Parkinson disease	P01230	Src kinase	TAKRU|Ensembl=ENSTRUG00000014739|UniProtKB=H2UL58	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00055	Transcription regulation by bZIP transcription factor	P01389	TTF2	PANTR|Ensembl=ENSPTRG00000005395|UniProtKB=H2Q6S6	MTERF domain containing 3	ISS	604718	OMIM	PTHR15437:SF1	TRANSCRIPTION TERMINATION FACTOR 2, MITOCHONDRIAL
P00029	Huntington disease	P00765	Hip-1	HUMAN|HGNC=4913|UniProtKB=O00291	Huntingtin-interacting protein 1	IPI	9147654	PubMed	PTHR10407:SF14	HUNTINGTIN-INTERACTING PROTEIN 1
P00006	Apoptosis signaling pathway	P00269	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01148	Grb2	RAT|RGD=1306884|UniProtKB=Q4KM68	GRB2-related adaptor protein	ISS	11971956	PubMed	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	XENTR|Xenbase=XB-GENE-1002222|UniProtKB=F6YTJ1	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF317	MYOSIN-9
P00034	Integrin signalling pathway	P00936	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MONDO|Ensembl=ENSMODG00000001196|UniProtKB=F7GH85	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	HUMAN|HGNC=10934|UniProtKB=P54219	Chromaffin granule amine transporter	ISS	92370677	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00036	Interleukin signaling pathway	P00990	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00647	SHP2	TAKRU|Ensembl=ENSTRUG00000018529|UniProtKB=H2VDZ2	Tyrosine-protein phosphatase non-receptor type	ISS	8096088	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00848	Grb	HUMAN|HGNC=4562|UniProtKB=Q13588	GRB2-related adapter protein	ISS	51702266	gi	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P00047	PDGF signaling pathway	P01173	STAT	HUMAN|HGNC=11364|UniProtKB=P40763	Signal transducer and activator of transcription 3	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00006	Apoptosis signaling pathway	P00269	MAPK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00269	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00552	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000021900|UniProtKB=F1MFK1	Uncharacterized protein	ISS	11554554	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	MACMU|Ensembl=ENSMMUG00000009341|UniProtKB=F6UA54	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	BOVIN|Ensembl=ENSBTAG00000034854|UniProtKB=F1N246	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	CANLF|Ensembl=ENSCAFG00000000415|UniProtKB=E2R2K4	Uncharacterized protein	ISS	10476970	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04395	Vasopressin synthesis	P04594	Neurophysin	HUMAN|HGNC=8528|UniProtKB=P01178	Oxytocin-neurophysin 1	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00019	Endothelin signaling pathway	P00586	Gq	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04398	p53 pathway feedback loops 2	P04661	PI3K	ANOGA|EnsemblGenome=AGAP011036|UniProtKB=A0NBA9	AGAP011036-PA (Fragment)	ISS	7937853	PubMed	PTHR10048:SF64	LD28067P
P05915	Opioid proenkephalin pathway	P05990	K+ channel	RAT|RGD=621451|UniProtKB=Q9ES08	Potassium channel subfamily K member 9	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00046	Oxidative stress response	P01129	JNK1/2	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00014	Cholesterol biosynthesis	P00499	Farnesyl-diphosphate farnesyltransferase	YEAST|SGD=S000001233|UniProtKB=P29704	Squalene synthase	ISS			PTHR11626:SF2	SQUALENE SYNTHASE
P00021	FGF signaling pathway	P00639	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	95096035	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MOUSE|MGI=MGI=107619|UniProtKB=P70174	Histamine H1 receptor	IDA			PTHR43914:SF2	HISTAMINE H1 RECEPTOR
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05915	Opioid proenkephalin pathway	P05994	G-protein	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P05913	Enkephalin release	P05972	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00017	DNA replication	P00533	Pol delta	HUMAN|HGNC=9176|UniProtKB=P49005	DNA polymerase delta subunit 2	IPI	12522211	PubMed	PTHR10416:SF0	DNA POLYMERASE DELTA SUBUNIT 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	P04630	PP2A	MONDO|Ensembl=ENSMODG00000014177|UniProtKB=F6U7A6	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00260	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00047	PDGF signaling pathway	P01161	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	12411479	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00057	Wnt signaling pathway	P01451	Galpha	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00034	Integrin signalling pathway	P00907	ERK	MONDO|Ensembl=ENSMODG00000009766|UniProtKB=F6TFL4	Uncharacterized protein	ISS	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00006	Apoptosis signaling pathway	P00266	SEK1	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00053	T cell activation	P01307	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	IPI	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ANOGA|EnsemblGenome=AGAP001676|UniProtKB=Q7PXZ8	AGAP001676-PA	IC	14684598	PubMed	PTHR11937:SF368	ACTIN, INDIRECT FLIGHT MUSCLE
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CHICK|Ensembl=ENSGALG00000014620|UniProtKB=F1N8P3	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00010	B cell activation	P00380	fos	CANLF|Ensembl=ENSCAFG00000017040|UniProtKB=E2QYK5	Uncharacterized protein	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P05915	Opioid proenkephalin pathway	P05994	G-protein	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00029	Huntington disease	P00807	Actin	PUCGT|EnsemblGenome=PGTG_05488|UniProtKB=E3K4I1	Actin	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	HUMAN|HGNC=290|UniProtKB=P35626	Beta-adrenergic receptor kinase 2	RCA			PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	BOVIN|Ensembl=ENSBTAG00000037985|UniProtKB=F1MCK3	Muscarinic acetylcholine receptor	ISS	11166329	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	BACSU|EnsemblGenome=BSU21820|UniProtKB=P11044	Thymidylate synthase 2	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06782	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	RCA	176892	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00007	Axon guidance mediated by semaphorins	P00340	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IC	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00057	Wnt signaling pathway	P01456	beta-arrestin	CANLF|Ensembl=ENSCAFG00000015905|UniProtKB=E2QUH6	Uncharacterized protein	ISS	9388255	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=5287|UniProtKB=P28222	5-hydroxytryptamine receptor 1B	IDA	12181435	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P00018	EGF receptor signaling pathway	P00564	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00805	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01160	IP3 receptor	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00018	EGF receptor signaling pathway	P00551	Akt	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	IGI	12089061	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01153	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00887	IRS 1-4	RAT|RGD=2922|UniProtKB=P35570	Insulin receptor substrate 1	ISS	12701063	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02741	Flavin biosynthesis	P02936	FAD synthetase	XENTR|Xenbase=XB-GENE-1010122|UniProtKB=Q28GD6	Riboflavin kinase	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04653	cdk2	DANRE|ZFIN=ZDB-GENE-040426-2741|UniProtKB=Q7ZWB1	Cyclin-dependent kinase 2	ISS	1846803	PubMed	PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00049	Parkinson disease	P01212	p38 MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00025	Hedgehog signaling pathway	P00682	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00053	T cell activation	P01312	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00107	kinesin	BOVIN|Gene=KLC4|UniProtKB=Q2HJJ0	Kinesin light chain 4	ISS	11740561	PubMed	PTHR19959:SF139	KINESIN LIGHT CHAIN 4
P00029	Huntington disease	P00790	beta-Tubulin	CAEEL|WormBase=WBGene00006539|UniProtKB=G5EF01	TuBulin, Beta	TAS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MOUSE|MGI=MGI=87909|UniProtKB=P62737	Actin, aortic smooth muscle	IC	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00029	Huntington disease	P00774	Dynein complex	STRPU|EnsemblGenome=SPU_024498|UniProtKB=W4Z8M4	Uncharacterized protein	ISS	9454836	PubMed	PTHR11886:SF35	DYNEIN LIGHT CHAIN 2, CYTOPLASMIC
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00255	Notch	RAT|RGD=3187|UniProtKB=Q07008	Neurogenic locus notch homolog protein 1	ISS	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00049	Parkinson disease	P01235	Fyn kinase	BOVIN|Ensembl=ENSBTAG00000011851|UniProtKB=A0JNB0	Tyrosine-protein kinase Fyn	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	BOVIN|Ensembl=ENSBTAG00000034854|UniProtKB=F1N246	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P02753	Methionine biosynthesis	P03024	Homocysteine transmethylase	BOVIN|Gene=MTR|UniProtKB=Q4JIJ3	Methionine synthase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P00029	Huntington disease	P00775	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04555	PDK	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	IDA	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00006	Apoptosis signaling pathway	P00322	Cytochrome C	MOUSE|MGI=MGI=88578|UniProtKB=P62897	Cytochrome c, somatic	ISS	11836241	PubMed	PTHR11961:SF15	CYTOCHROME C
P00047	PDGF signaling pathway	P01143	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00059	p53 pathway	P01485	p53	ORNAN|Ensembl=ENSOANG00000013795|UniProtKB=F7DUR2	Uncharacterized protein (Fragment)	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00056	VEGF signaling pathway	P01417	Raf	MOUSE|MGI=MGI=88190|UniProtKB=P28028	Serine/threonine-protein kinase B-raf	ISS	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P06959	CCKR signaling map	P07127	Adenylate cyclase	HUMAN|HGNC=232|UniProtKB=Q08828	Adenylate cyclase type 1	RCA	198332	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	TAS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00007	Axon guidance mediated by semaphorins	P00340	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12912997	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	PANTR|Ensembl=ENSPTRG00000002775|UniProtKB=H2RB55	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P02788	Xanthine and guanine salvage pathway	P03245	Guanine phosphoribosyl transferase	LEIMA|EnsemblGenome=LmjF.21.0845|UniProtKB=Q4QCC3	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000016187|UniProtKB=F1N213	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CHICK|Ensembl=ENSGALG00000006576|UniProtKB=E1BUE5	Uncharacterized protein	ISS			PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IDA	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	TAS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00005	Angiogenesis	P00231	HSP27	RAT|RGD=61306|UniProtKB=P42930	Heat shock protein beta-1	RCA			PTHR11527:SF114	HEAT SHOCK PROTEIN BETA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P02772	Pyruvate metabolism	P03135	Phosphoenolpyruvate Carboxykinase	PANTR|Ensembl=ENSPTRG00000013664|UniProtKB=H2QKN1	Uncharacterized protein	ISS	8325643	PubMed	PTHR11561:SF1	PHOSPHOENOLPYRUVATE CARBOXYKINASE, CYTOSOLIC  GTP
P00005	Angiogenesis	P00243	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00025	Hedgehog signaling pathway	P00682	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04393	Ras Pathway	P04552	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00059	p53 pathway	P01486	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00048	PI3 kinase pathway	P01177	P110ACT	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	CHICK|Ensembl=ENSGALG00000011452|UniProtKB=F1P1K3	Uncharacterized protein	ISS	10940259	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P05913	Enkephalin release	P05974	G-Protein (i)	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00539	14-3-3	HUMAN|HGNC=12849|UniProtKB=P31946	14-3-3 protein beta/alpha	IGI	10407019	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	RAT|RGD=621516|UniProtKB=G3V6P8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P05917	Opioid proopiomelanocortin pathway	P06011	AC	BOVIN|Ensembl=ENSBTAG00000019210|UniProtKB=F1MJV4	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04397	p53 pathway by glucose deprivation	P04640	p53	MOUSE|MGI=MGI=1330810|UniProtKB=O88898	Tumor protein 63	TAS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	SCHPO|PomBase=SPAC23G3.11|UniProtKB=Q9P7S2	Probable 26S proteasome regulatory subunit rpn6	ISS	21848401	PubMed	PTHR10678:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11
P04395	Vasopressin synthesis	P04590	Vasopressin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04398	p53 pathway feedback loops 2	P04669	ATM	MOUSE|MGI=MGI=107202|UniProtKB=Q62388	Serine-protein kinase ATM	ISS			PTHR11139:SF72	SERINE-PROTEIN KINASE ATM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	ISS	11535291	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00034	Integrin signalling pathway	P00944	Actin	BOVIN|Gene=ACTB|UniProtKB=P60712	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00047	PDGF signaling pathway	P01143	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	13430383	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05913	Enkephalin release	P05974	G-Protein (i)	DROME|FlyBase=FBgn0001122|UniProtKB=P16378	G protein alpha o subunit	IC	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01428	Frizzled	RAT|RGD=2321905|UniProtKB=D4ACM8	Protein Fzd7	ISS	11212302	PubMed	PTHR11309:SF31	FRIZZLED-7
P00010	B cell activation	P00372	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8051109	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	RAT|RGD=621408|UniProtKB=Q62763	Casein kinase I isoform gamma-3	IDA	10617630	PubMed	PTHR11909:SF151	CASEIN KINASE I ISOFORM GAMMA-3
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00010	B cell activation	P00398	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00054	Toll receptor signaling pathway	P01367	MKK3	MOUSE|MGI=MGI=1346868|UniProtKB=O09110	Dual specificity mitogen-activated protein kinase kinase 3	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00053	T cell activation	P01332	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	STRPU|EnsemblGenome=SPU_012282|UniProtKB=W4Y969	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF369	ACTIN-42A
P00009	Axon guidance mediated by netrin	P00356	UNC-5	MACMU|Ensembl=ENSMMUG00000006309|UniProtKB=F7HIS3	Uncharacterized protein	ISS			PTHR12582:SF7	NETRIN RECEPTOR UNC5C
P00029	Huntington disease	P00788	Calpain	DROME|FlyBase=FBgn0012051|UniProtKB=Q11002	Calpain-A	IDA	11675509	PubMed	PTHR10183:SF386	CALPAIN-A-RELATED
P00018	EGF receptor signaling pathway	P00543	ERK1-2	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	12471242	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00036	Interleukin signaling pathway	P00965	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IC	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	ORYSJ|EnsemblGenome=OS10G0503200|UniProtKB=Q337F3	Dihydrofolate synthetase/folylpolyglutamate synthetase, putative, expressed	ISS			PTHR11136:SF6	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00927	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00059	p53 pathway	P01480	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00019	Endothelin signaling pathway	P00570	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176910	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05913	Enkephalin release	P05976	Enkephalin	MOUSE|MGI=MGI=104629|UniProtKB=P22005	Proenkephalin-A	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P05730	Endogenous cannabinoid signaling	P05746	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	TAS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00018	EGF receptor signaling pathway	P00558	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IGI	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00019	Endothelin signaling pathway	P00585	ECE1-3	CANLF|Ensembl=ENSCAFG00000014920|UniProtKB=F1PK66	Uncharacterized protein	ISS	12464614	PubMed	PTHR11733:SF130	ENDOTHELIN-CONVERTING ENZYME 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MOUSE|MGI=MGI=95819|UniProtKB=P35438	Glutamate receptor ionotropic, NMDA 1	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00302	ATF	PANTR|Ensembl=ENSPTRG00000006555|UniProtKB=H2Q8N0	Uncharacterized protein	ISS			PTHR23351:SF10	JUN DIMERIZATION PROTEIN 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000011231|UniProtKB=F6WXV4	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02748	Isoleucine biosynthesis	P02997	Acetolactate synthase	METAC|EnsemblGenome=MA_1354|UniProtKB=Q8TR30	Acetolactate synthase, large subunit	ISS			PTHR18968:SF129	SUBFAMILY NOT NAMED
P00049	Parkinson disease	P01211	ERK	ORYSJ|EnsemblGenome=OS06G0154500|UniProtKB=Q84UI5	Mitogen-activated protein kinase 1	ISS			PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P00046	Oxidative stress response	P01129	JNK1/2	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00005	Angiogenesis	P00190	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	20908895	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00047	PDGF signaling pathway	P01143	ERK	CHICK|Ensembl=ENSGALG00000004690|UniProtKB=Q5F3W3	Mitogen-activated protein kinase 6	ISS	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	TAS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00059	p53 pathway	P04633	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01181	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	DROME|FlyBase=FBgn0019985|UniProtKB=P91685	Metabotropic glutamate receptor	IDA			PTHR24060:SF137	METABOTROPIC GLUTAMATE RECEPTOR
P00021	FGF signaling pathway	P00647	SHP2	BOVIN|Ensembl=ENSBTAG00000002048|UniProtKB=F1N339	Tyrosine-protein phosphatase non-receptor type	ISS	14534538	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	DICDI|dictyBase=DDB_G0292996|UniProtKB=P03967	Ras-like protein rasD	ISS	6091907	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	RAT|RGD=1306522|UniProtKB=Q4L0E8	Regulator of G-protein signaling 18	ISS	11563974	PubMed	PTHR10845:SF155	REGULATOR OF G-PROTEIN SIGNALING 18
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02748	Isoleucine biosynthesis	P02997	Acetolactate synthase	PYRAE|EnsemblGenome=PAE3300|UniProtKB=Q8ZTD9	Acetolactate synthase	ISS			PTHR18968:SF13	ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL
P00054	Toll receptor signaling pathway	P01368	MKK2	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00049	Parkinson disease	P01237	Complex I	NEUCR|EnsemblGenome=EFNCRG00000004355|UniProtKB=P40915	NADH-ubiquinone oxidoreductase 24 kDa subunit, mitochondrial	TAS	3100899	PubMed	PTHR10371:SF3	NADH DEHYDROGENASE  UBIQUINONE  FLAVOPROTEIN 2, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	MACMU|Ensembl=ENSMMUG00000012657|UniProtKB=F7E7J1	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	SCHPO|PomBase=SPBC12C2.11|UniProtKB=Q09740	Probable glutamine--fructose-6-phosphate aminotransferase [isomerizing]	ISS			PTHR10937:SF0	GH12731P-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00047	PDGF signaling pathway	P01151	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	XENTR|Xenbase=XB-GENE-493937|UniProtKB=Q5M8T9	Actin, alpha 2, smooth muscle, aorta	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	IC	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	CHICK|Ensembl=ENSGALG00000011558|UniProtKB=F1NWV6	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04661	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	CANLF|Ensembl=ENSCAFG00000002528|UniProtKB=F1PS63	Receptor protein serine/threonine kinase	ISS	10683140	PubMed	PTHR23255:SF61	TGF-BETA RECEPTOR TYPE-1
P00034	Integrin signalling pathway	P00906	Rap1	PANTR|Ensembl=ENSPTRG00000005197|UniProtKB=A5A6J7	Ras-related protein Rap-1b	ISS	8576107	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00006	Apoptosis signaling pathway	P00317	Fos	TAKRU|Ensembl=ENSTRUG00000010579|UniProtKB=H2TPU7	Uncharacterized protein	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ORNAN|Ensembl=ENSOANG00000013961|UniProtKB=F6VPY1	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00029	Huntington disease	P00780	Microtubule	TRIAD|EnsemblGenome=TriadG63686|UniProtKB=B3RQ31	Beta-tubulin	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00053	T cell activation	P01311	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IDA	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	RAT|RGD=3772|UniProtKB=P52631	Signal transducer and activator of transcription 3	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00034	Integrin signalling pathway	P00940	Src	BOVIN|Ensembl=ENSBTAG00000008938|UniProtKB=E1BIM8	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00021	FGF signaling pathway	P00645	Rac	DICPU|Gene=DICPUDRAFT_55703|UniProtKB=F0ZN94	Putative uncharacterized protein racC	ISS	8649368	PubMed	PTHR24072:SF117	RHO-RELATED PROTEIN RACC
P06664	Gonadotropin-releasing hormone receptor pathway	P06789	Prolactin	MOUSE|MGI=MGI=97762|UniProtKB=P06879	Prolactin	RCA			PTHR11417:SF5	PROLACTIN
P00005	Angiogenesis	P00211	GSK3beta	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00011	Blood coagulation	P00443	Fibrin polymer cross-linked	HUMAN|HGNC=3662|UniProtKB=P02675	Fibrinogen beta chain	ISS	11761631	gi	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00223	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P06216	SCW signaling pathway	P06322	SCW full length	DROME|FlyBase=FBgn0005590|UniProtKB=P54631	Protein screw	IEA	7958918	PubMed	PTHR11848:SF54	PROTEIN 60A-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00010	B cell activation	P00398	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95815|UniProtKB=P39087	Glutamate receptor ionotropic, kainate 2	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04371	5-Hydroxytryptamine biosynthesis	P04400	Aromatic L-amino acid decarboxylase	HUMAN|HGNC=2719|UniProtKB=P20711	Aromatic-L-amino-acid decarboxylase	ISS	107930	OMIM	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	ASHGO|EnsemblGenome=AGOS_AGL093W|UniProtKB=Q9HF56	Cell division control protein 42	ISS	11156982	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00056	VEGF signaling pathway	P01411	Ras	DICDI|dictyBase=DDB_G0293434|UniProtKB=P15064	Ras-like protein rasG	ISS	89128893	PubMed	PTHR24070:SF282	RAS GTPASE-RELATED
P00052	TGF-beta signaling pathway	P01292	RSmads	TAKRU|Ensembl=ENSTRUG00000014344|UniProtKB=H2UI95	Mothers against decapentaplegic homolog	ISS	12736218	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00060	Ubiquitin proteasome pathway	P01492	E1	RAT|RGD=1304817|UniProtKB=Q641Y5	Ubiquitin-like modifier-activating enzyme ATG7	ISS			PTHR10953:SF3	UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7
P04398	p53 pathway feedback loops 2	P04661	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	12660731	PubMed	PTHR10048:SF14	PI-3 KINASE
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	ORNAN|Ensembl=ENSOANG00000006811|UniProtKB=F6WBD5	Uncharacterized protein	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00019	Endothelin signaling pathway	P00577	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	IGI	9620264	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P06664	Gonadotropin-releasing hormone receptor pathway	P06852	nPKCs	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05918	p38 MAPK pathway	P06023	MEF	RAT|RGD=1561733|UniProtKB=Q6AXR7	Myocyte enhancer factor 2B	ISS			PTHR11945:SF348	MYOCYTE-SPECIFIC ENHANCER FACTOR 2B
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01070	K+ channel	PANTR|Ensembl=ENSPTRG00000013736|UniProtKB=H2QKS4	Uncharacterized protein	ISS	12223552	PubMed	PTHR11537:SF6	POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 2
P00054	Toll receptor signaling pathway	P01354	NFkappaB	RAT|RGD=727889|UniProtKB=Q7TQN4	Protein Rela	ISS	10049353	PubMed	PTHR24169:SF1	TRANSCRIPTION FACTOR P65
P00029	Huntington disease	P00775	Rac	DICDI|dictyBase=DDB_G0268622|UniProtKB=P34145	Rho-related protein rac1B	TAS			PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00019	Endothelin signaling pathway	P00571	Pro ET1-4	MOUSE|MGI=MGI=95283|UniProtKB=P22387	Endothelin-1	ISS	15117818	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P00036	Interleukin signaling pathway	P00973	PKB	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01235	Fyn kinase	CHICK|Gene=FYN|UniProtKB=Q05876	Tyrosine-protein kinase Fyn	IDA	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04395	Vasopressin synthesis	P04597	Signal Peptide	DANRE|ZFIN=ZDB-GENE-030407-2|UniProtKB=F8W5D0	Uncharacterized protein (Fragment)	ISS	192340	OMIM	PTHR11681:SF13	SUBFAMILY NOT NAMED
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	PRIPA|Gene=PPA21102|UniProtKB=H3FFR1	Uncharacterized protein	ISS			PTHR23431:SF3	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CHICK|Ensembl=ENSGALG00000028749|UniProtKB=Q5ZMQ2	Actin, cytoplasmic 2	ISS	11889139	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	CHICK|Ensembl=ENSGALG00000001476|UniProtKB=F1NSA8	Uncharacterized protein	ISS	8576107	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05918	p38 MAPK pathway	P05921	MKP5	MOUSE|MGI=MGI=1927070|UniProtKB=Q9ESS0	Dual specificity protein phosphatase 10	RCA	10597297	PubMed	PTHR10159:SF299	DUAL SPECIFICITY PROTEIN PHOSPHATASE 10
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000012036|UniProtKB=F7ALP1	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00046	Oxidative stress response	P01138	MKK4	RAT|RGD=1311192|UniProtKB=A0A0G2K3R1	Protein Map3k4	ISS	10207617	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00059	p53 pathway	G04694	p110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01306	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IDA	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00056	VEGF signaling pathway	P01413	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	IXOSC|EnsemblGenome=ISCW024111|UniProtKB=B7PBG2	Actin, putative (Fragment)	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04393	Ras Pathway	P04574	PLD	ARATH|TAIR=AT4G11840|UniProtKB=Q9T052	Phospholipase D gamma 3	ISS			PTHR18896:SF65	PHOSPHOLIPASE D BETA 1-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00053	T cell activation	P01296	TCR zeta	HUMAN|HGNC=1677|UniProtKB=P20963	T-cell surface glycoprotein CD3 zeta chain	IGI	9012833	PubMed	PTHR10035:SF2	T-CELL SURFACE GLYCOPROTEIN CD3 ZETA CHAIN
P00034	Integrin signalling pathway	P00922	Collagen	PANTR|Ensembl=ENSPTRG00000012991|UniProtKB=H2RDB1	Uncharacterized protein	ISS	10778855	PubMed	PTHR24023:SF714	COLLAGEN ALPHA-4 IV  CHAIN
P00018	EGF receptor signaling pathway	P00545	JNK1-3	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00046	Oxidative stress response	P01132	c-jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04375	5HT3 type receptor mediated signaling pathway	P04425	K+ channel	MOUSE|MGI=MGI=1100509|UniProtKB=O35111	Potassium channel subfamily K member 3	ISS	11875121	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00021	FGF signaling pathway	P00623	FGF	BOVIN|Ensembl=ENSBTAG00000020194|UniProtKB=A6H6W8	Fibroblast growth factor	ISS	97376484	PubMed	PTHR11486:SF77	FIBROBLAST GROWTH FACTOR 13
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8670|UniProtKB=Q9UN74	Protocadherin alpha-4	IDA	8120095	PubMed	PTHR24028:SF82	PROTOCADHERIN ALPHA-4
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00010	B cell activation	P00373	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	MACMU|Ensembl=ENSMMUG00000001387|UniProtKB=F7D0B4	Uncharacterized protein	ISS	14580336	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00018	EGF receptor signaling pathway	P00552	Ras	CANAL|EnsemblGenome=CaO19.1760|UniProtKB=Q59XU5	Ras-like protein 1	IGI	99445463	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00056	VEGF signaling pathway	P01423	p38MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00059	p53 pathway	P01486	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MOUSE|MGI=MGI=1923959|UniProtKB=Q9CVB6	Actin-related protein 2/3 complex subunit 2	ISS	17943202	gi	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	PSEAE|EnsemblGenome=PA4938|UniProtKB=Q9HUM6	Adenylosuccinate synthetase	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00045	Notch signaling pathway	P01103	Next	MACMU|Ensembl=ENSMMUG00000018116|UniProtKB=F7FGM9	Delta-like protein	ISS	10551863	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P04393	Ras Pathway	P04568	MKK3/6	HUMAN|HGNC=6843|UniProtKB=P46734	Dual specificity mitogen-activated protein kinase kinase 3	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	MOUSE|MGI=MGI=96611|UniProtKB=P11835	Integrin beta-2	IDA	10330002	PubMed	PTHR10082:SF15	INTEGRIN BETA-2
P00018	EGF receptor signaling pathway	P00541	Spry	MACMU|Ensembl=ENSMMUG00000001848|UniProtKB=F7GQV4	Protein sprouty homolog 1	ISS	98117253	PubMed	PTHR12365:SF10	PROTEIN SPROUTY HOMOLOG 1
P00021	FGF signaling pathway	P00646	RasGAP	PANTR|Ensembl=ENSPTRG00000015472|UniProtKB=H2QNH9	Uncharacterized protein	ISS	20475167	gi	PTHR10194:SF21	RAS GTPASE-ACTIVATING PROTEIN 2
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00029	Huntington disease	P00780	Microtubule	ARATH|TAIR=AT5G44340|UniProtKB=P24636	Tubulin beta-4 chain	IDA	12932731	PubMed	PTHR11588:SF245	TUBULIN BETA-4 CHAIN-RELATED
P00048	PI3 kinase pathway	P01199	Galpha	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02723	Adenine and hypoxanthine salvage pathway	P02811	Adenosine deaminase	CAEBR|Gene=CBG05749|UniProtKB=A8X1Q6	Protein CBG05749	ISS			PTHR11409:SF43	ADENOSINE DEAMINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MOUSE|MGI=MGI=1339710|UniProtKB=G3UW82	MCG140437, isoform CRA_d	ISS	10938134	PubMed	PTHR13140:SF385	MYOSIN-2
P00059	p53 pathway	P04630	PP2A	MACMU|Ensembl=ENSMMUG00000013047|UniProtKB=F7H808	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00020	FAS signaling pathway	P00617	FasL	HUMAN|HGNC=11936|UniProtKB=P48023	Tumor necrosis factor ligand superfamily member 6	ISS	12787569	PubMed	PTHR11471:SF33	TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 6
P00034	Integrin signalling pathway	P00931	Integrin beta	CHICK|Gene=ITGB1|UniProtKB=P07228	Integrin beta-1	IDA	3487386	PubMed	PTHR10082:SF28	INTEGRIN BETA-1
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P02728	Arginine biosynthesis	P02840	Argininosuccinate synthase	SULSO|EnsemblGenome=SSO0638|UniProtKB=Q9UX31	Argininosuccinate synthase	ISS			PTHR11587:SF2	ARGININOSUCCINATE SYNTHASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	PANTR|Gene=FPR3|UniProtKB=P79243	N-formyl peptide receptor 3 (Fragment)	IC			PTHR24225:SF16	N-FORMYL PEPTIDE RECEPTOR 3
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	HUMAN|HGNC=3373|UniProtKB=Q09472	Histone acetyltransferase p300	TAS	10769018	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00049	Parkinson disease	P01208	Hsp70	SYNY3|EnsemblGenome=BAA10059|UniProtKB=P22358	Chaperone protein dnaK2	ISS	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	CANLF|Ensembl=ENSCAFG00000009967|UniProtKB=F1PGZ2	Muscarinic acetylcholine receptor	ISS	11166329	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	TAS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00012	Cadherin signaling pathway	P00467	alpha-catenin	MONDO|Ensembl=ENSMODG00000012050|UniProtKB=F7ALE8	Uncharacterized protein	ISS	1768802	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00021	FGF signaling pathway	P00627	ERK1-2	YEAST|SGD=S000003272|UniProtKB=P14681	Mitogen-activated protein kinase KSS1	ISS			PTHR24055:SF338	MITOGEN-ACTIVATED PROTEIN KINASE KSS1
P00014	Cholesterol biosynthesis	P00498	Hydroxymethyl glutaryl CoA synthase	HUMAN|HGNC=5007|UniProtKB=Q01581	Hydroxymethylglutaryl-CoA synthase, cytoplasmic	ISS	123332	gi	PTHR43323:SF4	HYDROXYMETHYLGLUTARYL-COA SYNTHASE, CYTOPLASMIC
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	TAKRU|Ensembl=ENSTRUG00000009259|UniProtKB=H2TF39	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04393	Ras Pathway	P04547	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00321	HSP70	RAT|RGD=620664|UniProtKB=P14659	Heat shock-related 70 kDa protein 2	ISS	12150907	PubMed	PTHR19375:SF216	HEAT SHOCK-RELATED 70 KDA PROTEIN 2
P04393	Ras Pathway	P04555	PDK	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	IDA	12855688	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00018	EGF receptor signaling pathway	P00548	RKIP	PANTR|Ensembl=ENSPTRG00000020068|UniProtKB=H2QVV5	Uncharacterized protein	ISS			PTHR11362:SF70	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01414	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00012	Cadherin signaling pathway	P00474	Wnt	RAT|RGD=69079|UniProtKB=M0R9D3	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00012	Cadherin signaling pathway	P00470	F-actin	CHICK|Gene=ACTG2|UniProtKB=P63270	Actin, gamma-enteric smooth muscle	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00047	PDGF signaling pathway	P01148	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	12748278	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	TAS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00053	T cell activation	P01309	fos	MACMU|Ensembl=ENSMMUG00000010574|UniProtKB=A5A6H2	C-fos	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00079	alpha7 nicotinic acetylcholine receptor	CAEEL|WormBase=WBGene00000048|UniProtKB=Q18556	AcetylCholine Receptor	IDA			PTHR18945:SF528	ACETYLCHOLINE RECEPTOR
P00018	EGF receptor signaling pathway	P00546	GAP	DROME|FlyBase=FBgn0003969|UniProtKB=Q8IR23	GH13542p	ISS	7293174	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	PANTR|Ensembl=ENSPTRG00000008601|UniProtKB=H2QBY1	Arrestin, beta 2	ISS	11742073	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00057	Wnt signaling pathway	P01430	p53	CANLF|Gene=TP53|UniProtKB=Q29537	Cellular tumor antigen p53	IDA	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P04393	Ras Pathway	P04560	AP1	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	BOVIN|Ensembl=ENSBTAG00000009702|UniProtKB=F1N775	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF368	MYOSIN-8
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	8387895	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00005	Angiogenesis	P00213	FGF	HUMAN|HGNC=3665|UniProtKB=P05230	Fibroblast growth factor 1	IDA	12799194	PubMed	PTHR11486:SF86	FIBROBLAST GROWTH FACTOR 1
P00010	B cell activation	P00373	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IGI	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04393	Ras Pathway	P04542	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IDA	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00029	Huntington disease	P00807	Actin	PANTR|Ensembl=ENSPTRG00000006890|UniProtKB=H2Q943	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	MACMU|Ensembl=ENSMMUG00000010184|UniProtKB=F6SR09	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00056	VEGF signaling pathway	P01408	Akt/PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000012922|UniProtKB=H2QJF2	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00047	PDGF signaling pathway	P01150	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00235	c-Fos	TAKRU|Ensembl=ENSTRUG00000010579|UniProtKB=H2TPU7	Uncharacterized protein	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	BOVIN|Ensembl=ENSBTAG00000019988|UniProtKB=F1N2V3	Uncharacterized protein	RCA			PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P00054	Toll receptor signaling pathway	P01375	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00046	Oxidative stress response	P01135	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00048	PI3 kinase pathway	P01199	Galpha	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	IDA	12736250	PubMed	PTHR10202:SF18	PRESENILIN-1
P00034	Integrin signalling pathway	P00951	Jnk	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00046	Oxidative stress response	P01131	MKP5	CAEEL|WormBase=WBGene00007697|UniProtKB=Q9XXK8	Uncharacterized protein	ISS			PTHR10159:SF483	SUBFAMILY NOT NAMED
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00059	p53 pathway	P04633	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01286	TGFbeta	DANRE|ZFIN=ZDB-GENE-990630-10|UniProtKB=Q9W6I6	Signaling molecule lefty1	ISS	9759503	PubMed	PTHR11848:SF7	SIGNALING MOLECULE LEFTY1
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00049	Parkinson disease	P01211	ERK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MONDO|Ensembl=ENSMODG00000008701|UniProtKB=F6PWM3	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF22	FRIZZLED-3
P05913	Enkephalin release	P05971	CREB	HUMAN|HGNC=2352|UniProtKB=Q03060	cAMP-responsive element modulator	ISS			PTHR22952:SF97	CAMP-RESPONSIVE ELEMENT MODULATOR
P04398	p53 pathway feedback loops 2	P04668	p53	DANRE|ZFIN=ZDB-GENE-990415-270|UniProtKB=P79734	Cellular tumor antigen p53	TAS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	CANLF|Ensembl=ENSCAFG00000010255|UniProtKB=E2RPY4	Uncharacterized protein	ISS	2433589	PubMed	PTHR11767:SF52	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 4
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04567	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00038	JAK/STAT signaling pathway	P01027	STAT	MOUSE|MGI=MGI=103038|UniProtKB=P42227	Signal transducer and activator of transcription 3	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CANLF|Ensembl=ENSCAFG00000002617|UniProtKB=E2QUL1	Uncharacterized protein	ISS	11554554	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P04393	Ras Pathway	P04567	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	IDA	8700226	PubMed	PTHR10048:SF14	PI-3 KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00006	Apoptosis signaling pathway	P00277	Bi1	RAT|RGD=3842|UniProtKB=P55062	Bax inhibitor 1	ISS			PTHR23291:SF34	BAX INHIBITOR 1
P00048	PI3 kinase pathway	P01185	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00029	Huntington disease	P00796	Kainate receptor	MACMU|Ensembl=ENSMMUG00000009679|UniProtKB=F6YBQ8	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02724	Alanine biosynthesis	P02815	Branched chain amino acid aminotransferase	ARATH|TAIR=AT3G19710|UniProtKB=Q9LE06	Methionine aminotransferase BCAT4	ISS			PTHR42825:SF4	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 6-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	14765990	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00005	Angiogenesis	P00243	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00049	Parkinson disease	P01230	Src kinase	PANTR|Ensembl=ENSPTRG00000000411|UniProtKB=H2PYF9	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF224	TYROSINE-PROTEIN KINASE FGR
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01443	Phospholipase C	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00059	p53 pathway	P04634	Cdc2	PANTR|Ensembl=ENSPTRG00000005070|UniProtKB=H2Q670	Cyclin-dependent kinase 2	ISS	1846803	PubMed	PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P00018	EGF receptor signaling pathway	P00541	Spry	BOVIN|Ensembl=ENSBTAG00000008250|UniProtKB=A2VDU1	Protein sprouty homolog 4	ISS	12027893	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P04393	Ras Pathway	P04551	RalGDS	HUMAN|HGNC=30281|UniProtKB=Q9NZL6	Ral guanine nucleotide dissociation stimulator-like 1	ISS			PTHR23113:SF199	RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 1
P00047	PDGF signaling pathway	P01160	IP3 receptor	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04393	Ras Pathway	P04557	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	DROME|FlyBase=FBgn0032003|UniProtKB=Q7KTJ2	CG8349	ISS			PTHR11644:SF2	CYTIDINE DEAMINASE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IGI	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	THEMA|EnsemblGenome=TM_1658|UniProtKB=Q9X1Y8	S-adenosylmethionine synthase	ISS			PTHR11964:SF1	S-ADENOSYLMETHIONINE SYNTHASE
P00036	Interleukin signaling pathway	P00981	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	HUMAN|HGNC=7775|UniProtKB=O95644	Nuclear factor of activated T-cells, cytoplasmic 1	ISS	12015605	PubMed	PTHR12533:SF5	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00591	PLCbeta	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	SCHPO|PomBase=SPAC17A5.15c|UniProtKB=O13775	Probable glutamate--tRNA ligase, cytoplasmic	ISS			PTHR43097:SF5	GLUTAMATE--TRNA LIGASE, CYTOPLASMIC
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	IDA	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	MACMU|Ensembl=ENSMMUG00000009140|UniProtKB=F7E5B3	Adenylate kinase isoenzyme 6 isoform a	ISS			PTHR12595:SF8	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 9
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04398	p53 pathway feedback loops 2	P04664	cyclin E	HUMAN|HGNC=1589|UniProtKB=P24864	G1/S-specific cyclin-E1	IPI	12729791	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P05918	p38 MAPK pathway	P06018	MNK1	MOUSE|MGI=MGI=894316|UniProtKB=O08605	MAP kinase-interacting serine/threonine-protein kinase 1	RCA	11575158	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	ISS	11035810	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BOVIN|Ensembl=ENSBTAG00000005714|UniProtKB=Q3ZC07	Actin, alpha cardiac muscle 1	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00010	B cell activation	P00397	IKK	PANTR|Ensembl=ENSPTRG00000020202|UniProtKB=H2QW34	Uncharacterized protein	ISS	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00035	Interferon-gamma signaling pathway	P00957	IFNGR2	HUMAN|HGNC=5440|UniProtKB=P38484	Interferon gamma receptor 2	TAS	14525967	PubMed	PTHR20859:SF46	INTERFERON GAMMA RECEPTOR 2
P02765	Phenylalanine biosynthesis	P03099	Prephenate dehydratase	ARATH|TAIR=AT3G07630|UniProtKB=Q9SSE7	Arogenate dehydratase/prephenate dehydratase 2, chloroplastic	ISS			PTHR21022:SF1	AROGENATE DEHYDRATASE/PREPHENATE DEHYDRATASE 2, CHLOROPLASTIC
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8440264	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000002775|UniProtKB=H2RB55	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00021	FGF signaling pathway	P00627	ERK1-2	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IDA	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01078	VAChT	ANOGA|EnsemblGenome=AGAP002369|UniProtKB=Q7PR83	AGAP002369-PA	ISS	21863848	PubMed	PTHR23506:SF13	VESICULAR ACETYLCHOLINE TRANSPORTER
P00010	B cell activation	P00381	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01237	Complex I	HUMAN|HGNC=7717|UniProtKB=P19404	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	ISS	3100899	PubMed	PTHR10371:SF3	NADH DEHYDROGENASE  UBIQUINONE  FLAVOPROTEIN 2, MITOCHONDRIAL
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	XENTR|Xenbase=XB-GENE-971917|UniProtKB=A0JM97	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF42	REGULATOR OF G-PROTEIN SIGNALING 5
P00029	Huntington disease	P00799	JNK-2	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P02746	Heme biosynthesis	P02974	Uroporphyrinogen-III synthase	DROME|FlyBase=FBgn0038361|UniProtKB=Q9VF38	CG9589	ISS			PTHR12390:SF0	UROPORPHYRINOGEN-III SYNTHASE
P02766	Phenylethylamine degradation	P03103	Phenylethylamine oxidase	ARATH|TAIR=AT2G42490|UniProtKB=Q8L866	Amine oxidase	ISS			PTHR10638:SF18	AMINE OXIDASE
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	TAS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00006	Apoptosis signaling pathway	P00310	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MOUSE|MGI=MGI=1270862|UniProtKB=O88566	Axin-2	IEP	12356903	PubMed	PTHR10845:SF103	AXIN-2
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	IDA	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DANRE|ZFIN=ZDB-GENE-041001-104|UniProtKB=Q5TZD4	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00015	Circadian clock system	P00501	Clock	MOUSE|MGI=MGI=99698|UniProtKB=O08785	Circadian locomoter output cycles protein kaput	IDA	8171325	PubMed	PTHR23042:SF2	CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT
P00010	B cell activation	P00369	MEKK	MOUSE|MGI=MGI=1346873|UniProtKB=Q61083	Mitogen-activated protein kinase kinase kinase 2	IDA	8621389	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	RAT|RGD=628837|UniProtKB=P60711	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00006	Apoptosis signaling pathway	P00269	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00507	Rho	CANAL|CGD=CAL0000192659|UniProtKB=O42825	GTP-binding protein RHO1	ISS	11973360	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04393	Ras Pathway	P04570	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00019	Endothelin signaling pathway	P00567	PKG	CANLF|Ensembl=ENSCAFG00000008898|UniProtKB=F6Y448	cGMP-dependent protein kinase	ISS	22181250	PubMed	PTHR24353:SF24	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	YEAST|SGD=S000005460|UniProtKB=Q12236	Serine/threonine-protein kinase PKH2	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05940	GRK5	RAT|RGD=61985|UniProtKB=Q62833	G protein-coupled receptor kinase 5	RCA	8288567	PubMed	PTHR24355:SF27	G PROTEIN-COUPLED RECEPTOR KINASE 5
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00060	Ubiquitin proteasome pathway	P01492	E1	HUMAN|HGNC=30661|UniProtKB=Q9UBT2	SUMO-activating enzyme subunit 2	ISS			PTHR10953:SF5	SUMO-ACTIVATING ENZYME SUBUNIT 2
P00049	Parkinson disease	P01230	Src kinase	PANTR|Ensembl=ENSPTRG00000018521|UniProtKB=H2QTL3	Tyrosine-protein kinase	ISS	11162638	PubMed	PTHR24418:SF296	TYROSINE-PROTEIN KINASE FRK
P00054	Toll receptor signaling pathway	P01374	IRF3	CHICK|Gene=IRF3|UniProtKB=Q90643	Interferon regulatory factor 3	ISS			PTHR11949:SF2	INTERFERON REGULATORY FACTOR 7
P00037	Ionotropic glutamate receptor pathway	P01018	Glu1	CAEBR|Gene=CBG18112|UniProtKB=A8XT20	Protein CBR-GLR-1	ISS	10331083	PubMed	PTHR18966:SF297	GLUTAMATE RECEPTOR 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00049	Parkinson disease	P01238	14-3-3	ORNAN|Ensembl=ENSOANG00000007305|UniProtKB=F6XW91	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00005	Angiogenesis	P00237	FRP	MOUSE|MGI=MGI=108476|UniProtKB=Q61086	Frizzled-3	ISS	8717036	PubMed	PTHR11309:SF22	FRIZZLED-3
P00018	EGF receptor signaling pathway	P00540	MKK3,6	BOVIN|Ensembl=ENSBTAG00000010576|UniProtKB=A4IFH7	MAP2K3 protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CAEEL|WormBase=WBGene00004055|UniProtKB=Q17446	Mitogen-activated protein kinase pmk-1	IDA	11274345	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00005	Angiogenesis	P00200	Dsh	RAT|RGD=620632|UniProtKB=Q9WVB9	Segment polarity protein dishevelled homolog DVL-1	ISS	12549854	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P00010	B cell activation	P00375	Calmodulin	MONDO|Ensembl=ENSMODG00000023174|UniProtKB=F7D7P2	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF197	CALMODULIN-LIKE PROTEIN 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	MOUSE|MGI=MGI=102522|UniProtKB=Q8R3Z5	Voltage-dependent L-type calcium channel subunit beta-1	ISS	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00005	Angiogenesis	P00211	GSK3beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P06959	CCKR signaling map	P07166	MAPK1	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	RCA	15153424	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	CAEEL|WormBase=WBGene00002173|UniProtKB=Q9Y0A1	Inositol 1,4,5-trisphosphate receptor itr-1	IC	11007872	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00036	Interleukin signaling pathway	P00975	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00036	Interleukin signaling pathway	P00973	PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P02727	Androgen/estrogene/progesterone biosynthesis	P02828	Aromatase	RAT|RGD=2457|UniProtKB=P22443	Aromatase	RCA			PTHR24291:SF43	AROMATASE
P00029	Huntington disease	P00768	Apaf-1	PANTR|Ensembl=ENSPTRG00000005335|UniProtKB=H2R1S6	Apoptotic protease-activating factor 1	ISS	10364241	PubMed	PTHR22845:SF5	APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
P00010	B cell activation	P00384	p38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IDA	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00006	Apoptosis signaling pathway	P00310	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IDA	7565716	PubMed	PTHR10048:SF14	PI-3 KINASE
P04397	p53 pathway by glucose deprivation	P04641	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=94926|UniProtKB=P51436	D(4) dopamine receptor	IDA	11248120	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00057	Wnt signaling pathway	P01443	Phospholipase C	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	SCHPO|PomBase=SPBC32H8.07|UniProtKB=Q10282	Guanine nucleotide-binding protein subunit beta	IC	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00010	B cell activation	P00385	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01211	ERK	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	IDA	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MACMU|Ensembl=ENSMMUG00000001661|UniProtKB=F7GR69	Uncharacterized protein	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00562	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00014	Cholesterol biosynthesis	P00493	Geranyl trans-transferase	YEAST|SGD=S000003703|UniProtKB=P08524	Farnesyl pyrophosphate synthase	ISS	O64905	SPACC	PTHR11525:SF0	FARNESYL PYROPHOSPHATE SYNTHASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00020	FAS signaling pathway	P00601	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	P17325	SPACC	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P05731	GABA-B receptor II signaling	P05760	AC	MOUSE|MGI=MGI=99677|UniProtKB=O88444	Adenylate cyclase type 1	ISS	2491850	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	TAKRU|Ensembl=ENSTRUG00000017292|UniProtKB=H2V520	Uncharacterized protein	ISS			PTHR23431:SF3	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT2G18170|UniProtKB=Q39027	Mitogen-activated protein kinase 7	IDA	10851062	PubMed	PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P00037	Ionotropic glutamate receptor pathway	P00999	PSD95	RAT|RGD=628772|UniProtKB=Q9QX74	SH3 and multiple ankyrin repeat domains protein 2	ISS	20020275	PubMed	PTHR24135:SF17	SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN 2
P00034	Integrin signalling pathway	P00925	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IDA	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00019	Endothelin signaling pathway	P00590	IP3 R	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	IGI	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P06210	Activin beta signaling pathway	P06239	DAD	DROME|FlyBase=FBgn0020493|UniProtKB=Q5U110	Mothers against decapentaplegic homolog	IEA	9335505	PubMed	PTHR13703:SF44	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	DROME|FlyBase=FBgn0010399|UniProtKB=Q24418	Glutamate [NMDA] receptor subunit 1	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DROME|FlyBase=FBgn0000046|UniProtKB=P10981	Actin-87E	IC	14684598	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00046	Oxidative stress response	P01135	p38	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	TAS	20451058	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00006	Apoptosis signaling pathway	P00297	NFkappaB	RAT|RGD=1307189|UniProtKB=Q5U2Z4	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	ISS	20151924	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P04393	Ras Pathway	P04557	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	IDA	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IDA	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g242065|UniProtKB=A7S0V7	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P05730	Endogenous cannabinoid signaling	P05751	Galpha	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CHICK|Ensembl=ENSGALG00000014620|UniProtKB=F1N8P3	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01465	Ggamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00025	Hedgehog signaling pathway	P00682	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	IDA	10074940	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00018	EGF receptor signaling pathway	P00557	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00558	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	MOUSE|MGI=MGI=87940|UniProtKB=Q99MK8	Beta-adrenergic receptor kinase 1	IDA	10852916	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	RAT|RGD=2025|UniProtKB=P68136	Actin, alpha skeletal muscle	ISS	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00049	Parkinson disease	P01230	Src kinase	CHICK|Ensembl=ENSGALG00000003855|UniProtKB=P00523	Proto-oncogene tyrosine-protein kinase Src	IDA	8054685	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00018	EGF receptor signaling pathway	P00561	STAT	MOUSE|MGI=MGI=103035|UniProtKB=P42232	Signal transducer and activator of transcription 5B	IGI	22320921	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00015	Circadian clock system	P00504	Per	MOUSE|MGI=MGI=1098283|UniProtKB=O35973	Period circadian protein homolog 1	IDA	20570170	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P00010	B cell activation	P00371	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02728	Arginine biosynthesis	P02848	N-acetylglutamate synthase	RAT|RGD=1565783|UniProtKB=D4A904	N-acetylglutamate synthase (Predicted), isoform CRA_a	ISS			PTHR23342:SF0	N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IDA	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05731	GABA-B receptor II signaling	P05756	GABA-B receptor	PANTR|Ensembl=ENSPTRG00000021177|UniProtKB=H2R3Y0	Uncharacterized protein	ISS	9872315	PubMed	PTHR10519:SF62	GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05943	GRK2	CANLF|Ensembl=ENSCAFG00000011733|UniProtKB=E2R5J6	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P00020	FAS signaling pathway	P00601	c-Jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00034	Integrin signalling pathway	P00912	Arp2/3	ORNAN|Ensembl=ENSOANG00000004783|UniProtKB=F7FN72	Actin-related protein 2/3 complex subunit 3	ISS	12473693	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P05915	Opioid proenkephalin pathway	P05994	G-protein	DICPU|Gene=DICPUDRAFT_93216|UniProtKB=F1A421	Guanine nucleotide-binding protein subunit beta	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	CHICK|Ensembl=ENSGALG00000009320|UniProtKB=Q4JIM4	Presenilin-1	TAS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	ISS	97320448	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00059	p53 pathway	P04623	CBP	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04371	5-Hydroxytryptamine biosynthesis	P04400	Aromatic L-amino acid decarboxylase	HUMAN|HGNC=2719|UniProtKB=P20711	Aromatic-L-amino-acid decarboxylase	ISS	90339966	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	HUMAN|HGNC=7573|UniProtKB=P11055	Myosin-3	IEP	10938134	PubMed	PTHR13140:SF427	MYOSIN-3
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	LEIMA|EnsemblGenome=LmjF.19.1120|UniProtKB=Q4QDA3	Putative proteasome regulatory non-ATP-ase subunit	ISS			PTHR10539:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MOUSE|MGI=MGI=87905|UniProtKB=P68033	Actin, alpha cardiac muscle 1	IDA	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CHICK|Gene=ACTA2|UniProtKB=P08023	Actin, aortic smooth muscle	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	RAT|RGD=2744|UniProtKB=P31422	Metabotropic glutamate receptor 3	ISS	12351712	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00038	JAK/STAT signaling pathway	P01027	STAT	CHICK|Ensembl=ENSGALG00000003267|UniProtKB=Q6DV79	Signal transducer and activator of transcription 3	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00010	B cell activation	P00391	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00253	Axin	HUMAN|HGNC=903|UniProtKB=O15169	Axin-1	IDA	12356903	PubMed	PTHR10845:SF11	AXIN-1
P00052	TGF-beta signaling pathway	P01292	RSmads	RAT|RGD=620158|UniProtKB=Q9R1V3	Mothers against decapentaplegic homolog 5	TAS	12736218	PubMed	PTHR13703:SF36	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5
P00059	p53 pathway	P04609	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00384	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	DANRE|ZFIN=ZDB-GENE-980526-87|UniProtKB=Q92050	Protein Wnt-5b	TAS	11266476	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P02752	Mannose metabolism	P03015	GDP-Mannose 4,6-dehydratase	MACMU|Ensembl=ENSMMUG00000005779|UniProtKB=F6W0W9	GDP-mannose 4,6 dehydratase	ISS	9603974	PubMed	PTHR43715:SF1	GDP-MANNOSE 4,6 DEHYDRATASE
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	8327893	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2845|UniProtKB=P19327	5-hydroxytryptamine receptor 1A	IDA	12441358	PubMed	PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05913	Enkephalin release	P05977	G-Protein (s)	RAT|RGD=69319|UniProtKB=P54313	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	MONDO|Ensembl=ENSMODG00000001001|UniProtKB=F7E9M6	Uncharacterized protein	ISS			PTHR43521:SF1	ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	CHICK|Ensembl=ENSGALG00000006426|UniProtKB=E1BS97	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00019	Endothelin signaling pathway	P00572	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	MOUSE|MGI=MGI=1351660|UniProtKB=Q9JMK2	Casein kinase I isoform epsilon	ISS	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	IC	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00561	STAT	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	15825084	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	YEAST|SGD=S000000823|UniProtKB=P40016	26S proteasome regulatory subunit RPN3	ISS	97170075	PubMed	PTHR10758:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00011	Blood coagulation	P00405	FVIII	HUMAN|HGNC=3546|UniProtKB=P00451	Coagulation factor VIII	ISS	4503647	gi	PTHR45309:SF1	COAGULATION FACTOR VIII
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	YEAST|SGD=S000004017|UniProtKB=P23542	Aspartate aminotransferase, cytoplasmic	ISS			PTHR11879:SF22	ASPARTATE AMINOTRANSFERASE
P00054	Toll receptor signaling pathway	P01357	MEKK1	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	ISS	8643568	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	MOUSE|MGI=MGI=1933206|UniProtKB=A2AIR5	Protein Grin3a	ISS	11554554	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00048	PI3 kinase pathway	P01188	Gbetagamma	IXOSC|EnsemblGenome=ISCW009711|UniProtKB=B7Q3T6	THO complex subunit, putative	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00025	Hedgehog signaling pathway	P00682	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05923	beta-ARR2	BOVIN|Gene=ARRB2|UniProtKB=P32120	Beta-arrestin-2	RCA	4757780	gi	PTHR11792:SF20	BETA-ARRESTIN-2
P00012	Cadherin signaling pathway	P00475	Frizzled	MONDO|Ensembl=ENSMODG00000016310|UniProtKB=F7A659	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF31	FRIZZLED-7
P00009	Axon guidance mediated by netrin	P00364	cdc42	TAKRU|Ensembl=ENSTRUG00000008289|UniProtKB=H2T7U8	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF129	CDC42L PROTEIN
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IDA	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	NEMVE|Gene=v1g88970|UniProtKB=A7RPN8	Predicted protein (Fragment)	ISS	9753452	PubMed	PTHR23050:SF245	AT16150P-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	HUMAN|HGNC=5289|UniProtKB=P28221	5-hydroxytryptamine receptor 1D	IEA	11701344	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P02783	Tryptophan biosynthesis	P03208	Tryptophan synthase B	THEKO|EnsemblGenome=TK0257|UniProtKB=Q9YGB0	Tryptophan synthase beta chain 1	ISS			PTHR42882:SF1	TRYPTOPHAN SYNTHASE
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00508	Cofilin	PANTR|Ensembl=ENSPTRG00000003895|UniProtKB=H2Q279	Uncharacterized protein	ISS			PTHR11913:SF17	COFILIN-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00010	B cell activation	P00371	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	97442349	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=2446084|UniProtKB=Q8R5M2	Protein Wnt-9a	IDA	8717036	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00004	Alzheimer disease-presenilin pathway	P00163	Erb-B4 C-terminal fragment	RAT|RGD=620486|UniProtKB=Q62956	Receptor tyrosine-protein kinase erbB-4	IDA	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=104774|UniProtKB=P97717	Alpha-1B adrenergic receptor	IDA			PTHR24248:SF17	ALPHA-1B ADRENERGIC RECEPTOR
P00018	EGF receptor signaling pathway	P00560	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00018	EGF receptor signaling pathway	P00547	PP2A	BOVIN|Ensembl=ENSBTAG00000009245|UniProtKB=Q0P594	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00047	PDGF signaling pathway	P01142	p90RSK	MOUSE|MGI=MGI=1927343|UniProtKB=Q9Z1M4	Ribosomal protein S6 kinase beta-2	ISS	15116068	PubMed	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	PANTR|Gene=HTR1A|UniProtKB=Q9N298	5-hydroxytryptamine receptor 1A	ISS	2156831	PubMed	PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P05913	Enkephalin release	P05972	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	PANTR|Ensembl=ENSPTRG00000003699|UniProtKB=H2Q3R5	Syntaxin 3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P05913	Enkephalin release	P05972	PKA	LEIMA|EnsemblGenome=LmjF.18.1080|UniProtKB=Q27687	Protein kinase A catalytic subunit	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MOUSE|MGI=MGI=1925616|UniProtKB=Q9JMF3	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13	IC	10391901	PubMed	PTHR15936:SF2	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-13
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P05913	Enkephalin release	P05972	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00284	Flip	HUMAN|HGNC=1876|UniProtKB=O15519	CASP8 and FADD-like apoptosis regulator	IDA	8681376	PubMed	PTHR10454:SF8	CASP8 AND FADD-LIKE APOPTOSIS REGULATOR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	BOVIN|Gene=ARRB2|UniProtKB=P32120	Beta-arrestin-2	IDA	12464600	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00057	Wnt signaling pathway	P01444	Wnt	RAT|RGD=1306312|UniProtKB=D4A9D7	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	CAEEL|WormBase=WBGene00001680|UniProtKB=Q20636	Guanine nucleotide-binding protein subunit beta-2	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P02741	Flavin biosynthesis	P02935	GTP cyclohydrolase	STRCO|EnsemblGenome=CAA19934|UniProtKB=O88011	GTP cyclohydrolase-2	ISS			PTHR21327:SF30	GTP CYCLOHYDROLASE-2
P02783	Tryptophan biosynthesis	P03206	Anthranilate synthase	THEMA|EnsemblGenome=TM_0142|UniProtKB=Q08653	Anthranilate synthase component 1	ISS			PTHR11236:SF9	ANTHRANILATE SYNTHASE COMPONENT 1
P00053	T cell activation	P01311	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	3449797	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P04396	Vitamin D metabolism and pathway	P04602	RXR	DANRE|ZFIN=ZDB-GENE-980526-72|UniProtKB=Q7ZTI3	Retinoic acid receptor alpha-B	ISS			PTHR24082:SF115	RETINOIC ACID RECEPTOR ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05977	G-Protein (s)	DROME|FlyBase=FBgn0004623|UniProtKB=P29829	Guanine nucleotide-binding protein subunit beta-2	IC			PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	RCA	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00059	p53 pathway	P01486	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00020	FAS signaling pathway	P00615	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04396	Vitamin D metabolism and pathway	P04605	P450 reductase	CANLF|Ensembl=ENSCAFG00000013467|UniProtKB=F1P7R1	NADPH--cytochrome P450 reductase	ISS	2513880	PubMed	PTHR19384:SF17	NADPH--CYTOCHROME P450 REDUCTASE
P00034	Integrin signalling pathway	P00920	SOS	CHICK|Ensembl=ENSGALG00000013224|UniProtKB=F1NMA4	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	IDA	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00053	T cell activation	P01309	fos	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	TAS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	MOUSE|MGI=MGI=1202876|UniProtKB=Q9Z1J1	Transcription factor 7-like 1	TAS	9118222	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	BOVIN|Ensembl=ENSBTAG00000018373|UniProtKB=O02675	Dihydropyrimidinase-related protein 2	TAS	7637782	PubMed	PTHR11647:SF56	DIHYDROPYRIMIDINASE-RELATED PROTEIN 2
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00013	Cell cycle	P00489	CdkC	MOUSE|MGI=MGI=88316|UniProtKB=Q61457	G1/S-specific cyclin-E1	RCA			PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00020	FAS signaling pathway	P00603	Pro-Caspase9	HUMAN|HGNC=1511|UniProtKB=P55211	Caspase-9	IGI	8663294	PubMed	PTHR10454:SF157	CASPASE-9
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00005	Angiogenesis	P00217	STAT3	RAT|RGD=3772|UniProtKB=P52631	Signal transducer and activator of transcription 3	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00019	Endothelin signaling pathway	P00570	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P05915	Opioid proenkephalin pathway	P05985	Mu or Delta receptor	MOUSE|MGI=MGI=97438|UniProtKB=P32300	Delta-type opioid receptor	RCA	11259498	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04393	Ras Pathway	P04552	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	HUMAN|HGNC=3814|UniProtKB=O75593	Forkhead box protein H1	IGI	8878477	PubMed	PTHR11829:SF191	FORKHEAD BOX PROTEIN H1
P00046	Oxidative stress response	P01131	MKP5	PANTR|Ensembl=ENSPTRG00000005282|UniProtKB=H2Q6K9	Dual specificity protein phosphatase	ISS			PTHR10159:SF45	DUAL SPECIFICITY PROTEIN PHOSPHATASE 6
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000004896|UniProtKB=F7C2C6	Uncharacterized protein (Fragment)	ISS	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00037	Ionotropic glutamate receptor pathway	P01006	NR2C	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	ISS			PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04398	p53 pathway feedback loops 2	P04651	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00012	Cadherin signaling pathway	P00474	Wnt	RAT|RGD=1562253|UniProtKB=D4A3K6	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	10875333	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00054	Toll receptor signaling pathway	P01369	MKK1	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ARATH|TAIR=AT5G59370|UniProtKB=P53494	Actin-4	IC	14684598	PubMed	PTHR11937:SF366	ACTIN-4
P00047	PDGF signaling pathway	P01148	Grb2	DROME|FlyBase=FBgn0004638|UniProtKB=Q08012	Protein enhancer of sevenless 2B	ISS	4504111	gi	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	20216076	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00006	Apoptosis signaling pathway	P00303	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	11840290	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IC	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00005	Angiogenesis	P00194	Paxillin	MACMU|Ensembl=ENSMMUG00000000896|UniProtKB=F6T778	Uncharacterized protein	ISS			PTHR24216:SF27	TRANSFORMING GROWTH FACTOR BETA-1-INDUCED TRANSCRIPT 1 PROTEIN
P00048	PI3 kinase pathway	P01181	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00047	PDGF signaling pathway	P01162	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00045	Notch signaling pathway	G01541	E(spl)-C genes	MACMU|Ensembl=ENSMMUG00000002740|UniProtKB=F7HKP0	Uncharacterized protein	ISS	10860664	PubMed	PTHR10985:SF78	HAIRY/ENHANCER-OF-SPLIT RELATED WITH YRPW MOTIF PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	PANTR|Ensembl=ENSPTRG00000017091|UniProtKB=H2QR92	Proprotein convertase subtilisin/kexin type 1	ISS			PTHR42884:SF14	NEUROENDOCRINE CONVERTASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000012820|UniProtKB=F1MDL3	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P05731	GABA-B receptor II signaling	P05756	GABA-B receptor	MOUSE|MGI=MGI=2386030|UniProtKB=Q80T41	Gamma-aminobutyric acid type B receptor subunit 2	ISS	9872315	PubMed	PTHR10519:SF62	GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2
P00052	TGF-beta signaling pathway	P01275	P38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CANLF|Ensembl=ENSCAFG00000032632|UniProtKB=J9P2Q5	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00036	Interleukin signaling pathway	P00965	ERK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	92020947	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	IPI	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00025	Hedgehog signaling pathway	P00689	Patched	CHICK|Gene=PTCH1|UniProtKB=Q90693	Protein patched homolog 1	IDA	8620849	PubMed	PTHR10796:SF61	PROTEIN PATCHED HOMOLOG 1
P00057	Wnt signaling pathway	P01465	Ggamma	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IDA	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00049	Parkinson disease	P01236	Casein kinase II	CHICK|Ensembl=ENSGALG00000000889|UniProtKB=R9PXL1	Uncharacterized protein	IDA	10617630	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	SCHPO|PomBase=SPCC645.05c|UniProtKB=Q9USI6	Myosin type-2 heavy chain 1	IC			PTHR13140:SF555	MYOSIN HEAVY CHAIN, MUSCLE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04393	Ras Pathway	P04552	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IDA	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	BOVIN|Ensembl=ENSBTAG00000037794|UniProtKB=E1BP87	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF681	MYOSIN-4
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00012	Cadherin signaling pathway	P00462	Casein kinase II	RAT|RGD=619978|UniProtKB=P67874	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00054	Toll receptor signaling pathway	P01368	MKK2	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	DROME|FlyBase=FBgn0010223|UniProtKB=Q05337	Guanine nucleotide-binding protein G(f) subunit alpha	ISS			PTHR10218:SF229	GUANINE NUCLEOTIDE-BINDING PROTEIN G F  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01451	Galpha	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00005	Angiogenesis	P00252	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8051109	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P05916	Opioid prodynorphin pathway	P06002	G-protein	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	TAKRU|Ensembl=ENSTRUG00000000584|UniProtKB=H2RMN2	Uncharacterized protein	ISS	2039532	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00019	Endothelin signaling pathway	P00566	ERK	ARATH|TAIR=AT2G43790|UniProtKB=Q39026	Mitogen-activated protein kinase 6	ISS			PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00018	EGF receptor signaling pathway	P00565	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00046	Oxidative stress response	P01129	JNK1/2	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	TAS	12040174	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MOUSE|MGI=MGI=1196625|UniProtKB=O70421	Frizzled-1	TAS	11212302	PubMed	PTHR11309:SF81	FRIZZLED-1
P05914	Nicotine degradation	P05982	UGT1A4	PANTR|Ensembl=ENSPTRG00000013058|UniProtKB=H2R0U6	UDP-glucuronosyltransferase	ISS	12433823	PubMed	PTHR11926:SF173	UDP-GLUCURONOSYLTRANSFERASE 1-3-RELATED
P00053	T cell activation	P01311	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	ISS	94280860	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01188	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00049	Parkinson disease	P01208	Hsp70	RAT|RGD=2843|UniProtKB=P06761	78 kDa glucose-regulated protein	IDA	10934466	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00005	Angiogenesis	P00236	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01292	RSmads	MONDO|Ensembl=ENSMODG00000000500|UniProtKB=F6TU68	Mothers against decapentaplegic homolog	ISS	12736218	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	NAS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00059	p53 pathway	P01486	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	TAS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00078	Alpha1A/1B/1C	PANTR|Ensembl=ENSPTRG00000020100|UniProtKB=H2R0T2	Uncharacterized protein	ISS	6323229	PubMed	PTHR24248:SF16	ALPHA-1A ADRENERGIC RECEPTOR
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	MOUSE|MGI=MGI=106613|UniProtKB=Q60838	Segment polarity protein dishevelled homolog DVL-2	TAS	11212302	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P00045	Notch signaling pathway	P01103	Next	RAT|RGD=2937|UniProtKB=Q63722	Protein jagged-1	IDA	8955070	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00034	Integrin signalling pathway	P00922	Collagen	HUMAN|HGNC=2208|UniProtKB=Q14031	Collagen alpha-6(IV) chain	IDA	10778855	PubMed	PTHR24023:SF533	COLLAGEN ALPHA-6 IV  CHAIN
P00018	EGF receptor signaling pathway	P00545	JNK1-3	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IGI	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MONDO|Ensembl=ENSMODG00000004411|UniProtKB=F6SV50	Receptor protein serine/threonine kinase	ISS	10683140	PubMed	PTHR23255:SF58	ACTIVIN RECEPTOR TYPE-1C
P05734	Synaptic vesicle trafficking	P05780	Rab3A	HUMAN|HGNC=9777|UniProtKB=P20336	Ras-related protein Rab-3A	ISS	9194562	PubMed	PTHR24073:SF532	RAS-RELATED PROTEIN RAB-3A
P00003	Alzheimer disease-amyloid secretase pathway	P00091	Aph-1	MOUSE|MGI=MGI=2385110|UniProtKB=Q8BVF7	Gamma-secretase subunit APH-1A	ISS	12110170	PubMed	PTHR12889:SF3	GAMMA-SECRETASE SUBUNIT APH-1A
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00557	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IGI	7937853	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00053	T cell activation	P01330	IKK	BOVIN|Ensembl=ENSBTAG00000007599|UniProtKB=Q95KV0	Inhibitor of nuclear factor kappa-B kinase subunit beta	IGI	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00047	PDGF signaling pathway	P01146	Ikk	MOUSE|MGI=MGI=99484|UniProtKB=Q60680	Inhibitor of nuclear factor kappa-B kinase subunit alpha	RCA			PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	MOUSE|MGI=MGI=1277989|UniProtKB=Q9CZN7	Serine hydroxymethyltransferase	ISS			PTHR11680:SF17	SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	CAEEL|WormBase=WBGene00000067|UniProtKB=O45815	ACTin	IC	11889126	PubMed	PTHR11937:SF352	ACTIN
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00015	Circadian clock system	P00505	Cry	MACMU|Ensembl=ENSMMUG00000021808|UniProtKB=F7ENG9	Cryptochrome-1	ISS	10217146	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00029	Huntington disease	P00780	Microtubule	PANTR|Gene=TUBB8|UniProtKB=Q8WP14	Tubulin beta-8 chain	IDA	12932731	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00004	Alzheimer disease-presenilin pathway	P00114	actin	LEIMA|EnsemblGenome=LmjF.04.1230|UniProtKB=Q9U1E8	Actin	IDA			PTHR11937:SF155	ACTIN-5C-RELATED
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8971|UniProtKB=O00443	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	IPI	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00005	Angiogenesis	P00255	Notch	RAT|RGD=3188|UniProtKB=Q9QW30	Neurogenic locus notch homolog protein 2	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P04393	Ras Pathway	P04570	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P06959	CCKR signaling map	G07271	CHGA	HUMAN|HGNC=1929|UniProtKB=P10645	Chromogranin-A	RCA	9852054	PubMed	PTHR10583:SF1	CHROMOGRANIN-A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2520|UniProtKB=P61169	D(2) dopamine receptor	IDA	2039532	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00006	Apoptosis signaling pathway	P00269	MAPK	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00718	Phosphorylase a	MACMU|Ensembl=ENSMMUG00000014670|UniProtKB=F7ASP1	Alpha-1,4 glucan phosphorylase	ISS	4318782	PubMed	PTHR11468:SF12	GLYCOGEN PHOSPHORYLASE, LIVER FORM
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	SYNY3|EnsemblGenome=BAA18596|UniProtKB=P74494	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00018	EGF receptor signaling pathway	P00561	STAT	MACMU|Ensembl=ENSMMUG00000005617|UniProtKB=F6WDY6	Signal transducer and activator of transcription	ISS	12496413	PubMed	PTHR11801:SF19	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 4
P00059	p53 pathway	G04694	p110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00587	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00182	p38MAPK	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00036	Interleukin signaling pathway	P00990	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IPI	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00012	Cadherin signaling pathway	P00462	Casein kinase II	ANOGA|EnsemblGenome=AGAP005569|UniProtKB=Q7Q707	AGAP005569-PA	ISS	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=1560850|UniProtKB=F1LNJ8	Protein Pik3r6	ISS			PTHR15593:SF1	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 6
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	MOUSE|MGI=MGI=109284|UniProtKB=Q61144	Presenilin-2	TAS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00059	p53 pathway	P04616	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00021	FGF signaling pathway	P00629	PP2A	MACMU|Ensembl=ENSMMUG00000019771|UniProtKB=F7APV7	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform 1	ISS	12110603	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	IDA	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00005	Angiogenesis	P00256	PLC-gamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	CANLF|Ensembl=ENSCAFG00000004090|UniProtKB=F1PNQ0	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF291	ADENYLATE CYCLASE TYPE 3
P02722	Acetate utilization	P02801	Acetate kinase	METAC|EnsemblGenome=MA_3606|UniProtKB=Q8TK19	Acetate kinase	ISS			PTHR21060:SF11	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00203	Erk	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	TAS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	MOUSE|MGI=MGI=1349183|UniProtKB=P84444	C-C motif chemokine 21a	ISS			PTHR12015:SF72	C-C MOTIF CHEMOKINE 21
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	RAT|RGD=3566|UniProtKB=P49797	Regulator of G-protein signaling 3	IDA	8756726	PubMed	PTHR10845:SF4	REGULATOR OF G-PROTEIN SIGNALING 3
P00019	Endothelin signaling pathway	P00590	IP3 R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000029806|UniProtKB=F6V4U3	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF72	PROTOCADHERIN GAMMA-A8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04658	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	CANLF|Ensembl=ENSCAFG00000010871|UniProtKB=F1PXA0	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00034	Integrin signalling pathway	P00920	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00029	Huntington disease	P00807	Actin	XENTR|Xenbase=XB-GENE-480347|UniProtKB=Q6P640	Actin, alpha cardiac muscle 1	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04393	Ras Pathway	P04558	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05731	GABA-B receptor II signaling	P05754	Ggamma	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	RCA	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00019	Endothelin signaling pathway	P00566	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00114	actin	TAKRU|Ensembl=ENSTRUG00000005447|UniProtKB=P68142	Actin, cytoplasmic 1	IDA	3487386	PubMed	PTHR11937:SF354	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P02788	Xanthine and guanine salvage pathway	P03245	Guanine phosphoribosyl transferase	DANRE|ZFIN=ZDB-GENE-040426-1918|UniProtKB=Q7ZV49	Hprt1 protein	ISS			PTHR43340:SF6	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE
P00034	Integrin signalling pathway	P00924	Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	IPI	12068308	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	HUMAN|HGNC=3023|UniProtKB=P14416	D(2) dopamine receptor	IDA	1319557	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MACMU|Ensembl=ENSMMUG00000010440|UniProtKB=F7CRV6	Uncharacterized protein	ISS	12890691	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P02738	De novo purine biosynthesis	P02909	GDP reductase	CANAL|CGD=CAL0001524|UniProtKB=Q5A0N3	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00021	FGF signaling pathway	P00624	14-3-3	CANLF|Ensembl=ENSCAFG00000009514|UniProtKB=F1PKW7	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P02748	Isoleucine biosynthesis	P02994	Branched chain amino acid aminotransferase	RAT|RGD=2195|UniProtKB=P54690	Branched-chain-amino-acid aminotransferase, cytosolic	ISS			PTHR11825:SF51	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, CYTOSOLIC
P00018	EGF receptor signaling pathway	P00557	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	MACMU|Ensembl=ENSMMUG00000013637|UniProtKB=F7GL52	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00036	Interleukin signaling pathway	P00965	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000005520|UniProtKB=F7GFF0	Cadherin-11 preproprotein	ISS	8120095	PubMed	PTHR24027:SF85	CADHERIN-11
P00021	FGF signaling pathway	P00632	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00925	MEK	CANLF|Ensembl=ENSCAFG00000018530|UniProtKB=F1PXD3	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00030	Hypoxia response via HIF activation	P00819	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P02738	De novo purine biosynthesis	P02909	GDP reductase	TRYB2|Gene=Tb11.v4.0007|UniProtKB=Q382Q0	Ribonucleoside-diphosphate reductase small chain	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00036	Interleukin signaling pathway	P00974	Receptor subunit beta	MOUSE|MGI=MGI=96550|UniProtKB=P16297	Interleukin-2 receptor subunit beta	IGI	12231477	PubMed	PTHR23037:SF30	INTERLEUKIN-2 RECEPTOR SUBUNIT BETA
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=708420|UniProtKB=Q62688	Inactive phospholipase C-like protein 1	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9836512	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00021	FGF signaling pathway	P00645	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	HUMAN|HGNC=9855|UniProtKB=P62834	Ras-related protein Rap-1A	IDA	10476970	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MACMU|Ensembl=ENSMMUG00000001325|UniProtKB=F7BGU5	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00049	Parkinson disease	P01212	p38 MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04393	Ras Pathway	P04557	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P06959	CCKR signaling map	G06975	CXCL1	HUMAN|HGNC=4602|UniProtKB=P09341	Growth-regulated alpha protein	RCA	11518686	PubMed	PTHR10179:SF69	GROWTH-REGULATED ALPHA PROTEIN
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00021	FGF signaling pathway	P00625	MKK3,6	HUMAN|HGNC=6846|UniProtKB=P52564	Dual specificity mitogen-activated protein kinase kinase 6	RCA			PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	HALSA|EnsemblGenome=VNG_0997G|UniProtKB=Q9HQU8	Acetyl-CoA synthetase	ISS			PTHR24095:SF14	ACETYL-COENZYME A SYNTHETASE 1
P00021	FGF signaling pathway	P00648	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	YEAST|SGD=S000000028|UniProtKB=P31109	Synaptobrevin homolog 1	ISS			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00010	B cell activation	P00383	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IDA	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00017	DNA replication	P00527	Histones	STRPU|EnsemblGenome=SPU_025804|UniProtKB=W4ZCB8	Uncharacterized protein	ISS	12413958	PubMed	PTHR11426:SF20	HISTONE H3-LIKE CENTROMERIC PROTEIN A
P00052	TGF-beta signaling pathway	P01284	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00029	Huntington disease	P00807	Actin	CAEEL|WormBase=WBGene00000200|UniProtKB=P53489	Actin-related protein 2	IDA	10974003	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P02751	Lysine biosynthesis	P03011	N-succinyldiaminopimelate  aminotransferase	SULSO|EnsemblGenome=SSO0160|UniProtKB=Q7SI94	Acetylornithine/acetyl-lysine aminotransferase	IDA			PTHR11986:SF79	ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL
P00012	Cadherin signaling pathway	P00474	Wnt	DANRE|ZFIN=ZDB-GENE-081006-1|UniProtKB=F1Q9W3	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CHICK|Ensembl=ENSGALG00000011086|UniProtKB=P68139	Actin, alpha skeletal muscle	ISS	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00049	Parkinson disease	P01227	20S proteasome	TAKRU|Ensembl=ENSTRUG00000002016|UniProtKB=H2RWX2	Proteasome subunit beta type	TAS	12859888	PubMed	PTHR11599:SF45	PROTEASOME SUBUNIT BETA TYPE
P00058	mRNA splicing	P01478	U2	ARATH|TAIR=AT2G30260|UniProtKB=O22922	U2 small nuclear ribonucleoprotein B''	ISS			PTHR10501:SF32	U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B''-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04657	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	STRPU|EnsemblGenome=SPU_014285|UniProtKB=W4YEV4	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00057	Wnt signaling pathway	P01457	GBeta	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00029	Huntington disease	P00788	Calpain	MOUSE|MGI=MGI=1100850|UniProtKB=O35646	Calpain-6	IDA	11675509	PubMed	PTHR10183:SF381	CALPAIN-6
P00034	Integrin signalling pathway	P00907	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	PANTR|Ensembl=ENSPTRG00000013825|UniProtKB=H2RAK4	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00005	Angiogenesis	P00223	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01185	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01435	SWI/SNF	BOVIN|Ensembl=ENSBTAG00000031567|UniProtKB=F1MYU1	Uncharacterized protein	ISS	11532957	PubMed	PTHR12802:SF9	SWI/SNF COMPLEX SUBUNIT SMARCC1
P02751	Lysine biosynthesis	P03009	Aspartokinase	ORYSJ|EnsemblGenome=OS09G0294000|UniProtKB=Q69LG7	Aspartate kinase-homoserine dehydrogenase	ISS			PTHR43070:SF3	HOMOSERINE DEHYDROGENASE
P02774	Salvage pyrimidine deoxyribonucleotides	P03146	Deoxyuridine kinase	ECOLI|EcoGene=EG10994|UniProtKB=P23331	Thymidine kinase	ISS			PTHR11441:SF0	THYMIDINE KINASE, CYTOSOLIC
P00005	Angiogenesis	P00213	FGF	CHICK|Ensembl=ENSGALG00000007343|UniProtKB=P19596	Fibroblast growth factor 1	ISS	88296438	PubMed	PTHR11486:SF86	FIBROBLAST GROWTH FACTOR 1
P06959	CCKR signaling map	P07204	CD38	HUMAN|HGNC=1667|UniProtKB=P28907	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	RCA	20870729	PubMed	PTHR10912:SF5	ADP-RIBOSYL CYCLASE/CYCLIC ADP-RIBOSE HYDROLASE 1
P00004	Alzheimer disease-presenilin pathway	P00127	APP	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	MOUSE|MGI=MGI=104781|UniProtKB=P48542	G protein-activated inward rectifier potassium channel 2	IDA			PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	TAS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00644	p38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	LEIMA|EnsemblGenome=LmjF.35.3960|UniProtKB=E9AFM1	Protein kinase A catalytic subunit isoform 2	IC	10553940	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00059	p53 pathway	P01485	p53	BOVIN|Ensembl=ENSBTAG00000015460|UniProtKB=F1MKA9	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IDA	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00030	Hypoxia response via HIF activation	P00817	TOR	CANLF|Ensembl=ENSCAFG00000016648|UniProtKB=E2R2L2	Uncharacterized protein	ISS	14526383	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00021	FGF signaling pathway	P00637	MKK4,7	BOVIN|Ensembl=ENSBTAG00000012103|UniProtKB=A5PJP8	MAP2K4 protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	RAT|RGD=2735|UniProtKB=Q63273	Glutamate receptor ionotropic, kainate 5	ISS	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	PANTR|Ensembl=ENSPTRG00000034469|UniProtKB=H2Q2V0	Uncharacterized protein	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00029	Huntington disease	P00788	Calpain	CANLF|Ensembl=ENSCAFG00000005179|UniProtKB=F1PB20	Uncharacterized protein	ISS	11675509	PubMed	PTHR10183:SF370	CALPAIN-5
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	BRAFL|Gene=BRAFLDRAFT_124869|UniProtKB=C3ZEW0	Putative uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF263	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS			PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IDA	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00018	EGF receptor signaling pathway	P00539	14-3-3	CHICK|Gene_ORFName=RCJMB04_1e8|UniProtKB=Q5ZMT0	14-3-3 protein epsilon	ISS	9450960	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=4401|UniProtKB=O14775	Guanine nucleotide-binding protein subunit beta-5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00025	Hedgehog signaling pathway	P00693	Ubiquitin ligase	MACMU|Ensembl=ENSMMUG00000020766|UniProtKB=F7HEG3	Uncharacterized protein	ISS			PTHR11254:SF402	E3 UBIQUITIN-PROTEIN LIGASE UBR5
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00049	Parkinson disease	P01219	SAPK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00256	PLC-gamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	BOVIN|Ensembl=ENSBTAG00000014614|UniProtKB=P62739	Actin, aortic smooth muscle	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	HUMAN|HGNC=4586|UniProtKB=Q13224	Glutamate receptor ionotropic, NMDA 2B	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MONDO|Ensembl=ENSMODG00000014746|UniProtKB=F6YN64	Uncharacterized protein (Fragment)	ISS	10331083	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00021	FGF signaling pathway	P00624	14-3-3	BOVIN|Gene=YWHAB|UniProtKB=P68250	14-3-3 protein beta/alpha	IDA	91108808	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	PANTR|Ensembl=ENSPTRG00000003795|UniProtKB=H2Q3X5	Muscarinic acetylcholine receptor	ISS	12915051	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	HUMAN|HGNC=236|UniProtKB=O95622	Adenylate cyclase type 5	IC	92317082	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01149	MNK1/2	MOUSE|MGI=MGI=894316|UniProtKB=O08605	MAP kinase-interacting serine/threonine-protein kinase 1	ISS	97299868	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	RAT|RGD=3694|UniProtKB=Q01827	Synaptic vesicular amine transporter	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00539	14-3-3	MOUSE|MGI=MGI=891963|UniProtKB=P68254	14-3-3 protein theta	IGI	9211421	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MACMU|Ensembl=ENSMMUG00000021442|UniProtKB=F7EAQ8	Muscarinic acetylcholine receptor	ISS	12915051	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	DROME|FlyBase=FBgn0040206|UniProtKB=Q9V393	Kurtz arrestin	IDA	11742073	PubMed	PTHR11792:SF17	KURTZ ARRESTIN
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00807	Actin	TAKRU|Ensembl=ENSTRUG00000007989|UniProtKB=P68140	Actin, alpha skeletal muscle A	IDA	14684598	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Ensembl=ENSPTRG00000004233|UniProtKB=H2Q4N9	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	IDA	87218499	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00056	VEGF signaling pathway	P01408	Akt/PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00018	EGF receptor signaling pathway	P00564	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00047	PDGF signaling pathway	P01143	ERK	DICDI|dictyBase=DDB_G0283903|UniProtKB=Q54QB1	Extracellular signal-regulated kinase 2	ISS	12787066	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00057	Wnt signaling pathway	P01452	NFAT	HUMAN|HGNC=7778|UniProtKB=Q14934	Nuclear factor of activated T-cells, cytoplasmic 4	IDA	9462517	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	HUMAN|HGNC=10431|UniProtKB=Q15349	Ribosomal protein S6 kinase alpha-2	ISS	6755374	gi	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00193	SOS-1	CHICK|Ensembl=ENSGALG00000013224|UniProtKB=F1NMA4	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	ISS	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00036	Interleukin signaling pathway	P00964	p90RSK	MACMU|Ensembl=ENSMMUG00000020532|UniProtKB=F7D8E6	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF98	RIBOSOMAL PROTEIN S6 KINASE ALPHA-6
P00034	Integrin signalling pathway	P00928	alpha actinin	MOUSE|MGI=MGI=2137706|UniProtKB=Q7TPR4	Alpha-actinin-1	ISS	2116421	PubMed	PTHR43947:SF3	ALPHA-ACTININ-1
P00049	Parkinson disease	P01227	20S proteasome	HUMAN|HGNC=9540|UniProtKB=P49720	Proteasome subunit beta type-3	ISS	12859888	PubMed	PTHR11599:SF62	PROTEASOME SUBUNIT BETA TYPE-3
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01142	p90RSK	SCHPO|PomBase=SPCC4G3.08|UniProtKB=Q12706	Serine/threonine-protein kinase psk1	ISS			PTHR24351:SF166	RIBOSOMAL PROTEIN S6 KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000005903|UniProtKB=F1N1K8	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00047	PDGF signaling pathway	P01174	Rho	XENTR|Xenbase=XB-GENE-5897849|UniProtKB=F7EEN8	Uncharacterized protein	ISS	8288572	PubMed	PTHR14166:SF6	SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 2-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4394|UniProtKB=P19087	Guanine nucleotide-binding protein G(t) subunit alpha-2	ISS	10188796	PubMed	PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P00005	Angiogenesis	P00226	Delta/Serrate	CHICK|Ensembl=ENSGALG00000011696|UniProtKB=F1NMD6	Delta-like protein	ISS	9032014	PubMed	PTHR44097:SF1	PROTEIN JAGGED-2
P00005	Angiogenesis	P00233	CSL	HUMAN|HGNC=5724|UniProtKB=Q06330	Recombining binding protein suppressor of hairless	IDA	12145413	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00017	DNA replication	P00535	5' to 3' Exoribonulcease	MONDO|Ensembl=ENSMODG00000006163|UniProtKB=F7BS67	Uncharacterized protein	ISS	99339991	PubMed	PTHR12341:SF41	5'-3' EXORIBONUCLEASE 2
P00046	Oxidative stress response	P01136	Elk-1	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	3183861	gi	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	CHICK|Ensembl=ENSGALG00000006885|UniProtKB=P08642	GTPase HRas	ISS	3035212	PubMed	PTHR24070:SF385	GTPASE HRAS
P00047	PDGF signaling pathway	P01162	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00054	Toll receptor signaling pathway	P01379	Tollip	HUMAN|HGNC=16476|UniProtKB=Q9H0E2	Toll-interacting protein	ISS			PTHR16461:SF5	TOLL-INTERACTING PROTEIN
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00045	Notch signaling pathway	P01112	CoR	DROME|FlyBase=FBgn0036827|UniProtKB=Q9VVU4	CG6843	TAS	11112321	PubMed	PTHR13151:SF2	COREPRESSOR INTERACTING WITH RBPJ 1
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	RAT|RGD=628817|UniProtKB=Q8K4C8	Frizzled homolog 9 (Drosophila)	ISS	8717036	PubMed	PTHR11309:SF79	FRIZZLED-9
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00056	VEGF signaling pathway	P01411	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	XENTR|Xenbase=XB-GENE-483904|UniProtKB=F7ESG8	Receptor protein serine/threonine kinase (Fragment)	ISS			PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CAEEL|WormBase=WBGene00004045|UniProtKB=Q8IA75	Phosphoinositide phospholipase C	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P00034	Integrin signalling pathway	P00907	ERK	PANTR|Ensembl=ENSPTRG00000020224|UniProtKB=H2Q9G3	Mitogen-activated protein kinase 6	ISS	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MACMU|Ensembl=ENSMMUG00000015916|UniProtKB=F7AT89	Uncharacterized protein	ISS	17597586	PubMed	PTHR18945:SF401	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MACMU|Ensembl=ENSMMUG00000003949|UniProtKB=F6ZMA8	Uncharacterized protein	ISS			PTHR18945:SF768	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-10
P00034	Integrin signalling pathway	P00948	Rho	SCHPO|PomBase=SPAC20H4.11c|UniProtKB=Q9HE04	GTP-binding protein rho5	IGI	11973360	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	STRPU|EnsemblGenome=SPU_012282|UniProtKB=W4Y969	Uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF369	ACTIN-42A
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	DANRE|ZFIN=ZDB-GENE-000403-2|UniProtKB=P57095	Axin-2	IEP	9554852	PubMed	PTHR10845:SF103	AXIN-2
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00034	Integrin signalling pathway	P00945	Parvin	TAKRU|Ensembl=ENSTRUG00000006255|UniProtKB=H2SS83	Uncharacterized protein	ISS	11331308	PubMed	PTHR12114:SF6	ALPHA-PARVIN
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00029	Huntington disease	P00807	Actin	DICDI|dictyBase=DDB_G0289489|UniProtKB=P07828	Actin-18	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00020	FAS signaling pathway	P00622	FADD	PANTR|Ensembl=ENSPTRG00000004004|UniProtKB=H2Q4B6	FAS-associated death domain protein	ISS	9506948	PubMed	PTHR15077:SF8	FAS-ASSOCIATED DEATH DOMAIN PROTEIN
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	IC	176910	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TAKRU|Ensembl=ENSTRUG00000004787|UniProtKB=P53480	Actin, alpha cardiac	IC	11889139	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	BRAFL|Gene=BRAFLDRAFT_60807|UniProtKB=C3Y2F5	Putative uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00012	Cadherin signaling pathway	P00462	Casein kinase II	DANRE|ZFIN=ZDB-GENE-990415-28|UniProtKB=Q7ZU33	Ck2a2 protein	ISS	10617630	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00011	Blood coagulation	P00433	uPAR	HUMAN|HGNC=9053|UniProtKB=Q03405	Urokinase plasminogen activator surface receptor	ISS	11875697	gi	PTHR10624:SF6	UROKINASE PLASMINOGEN ACTIVATOR SURFACE RECEPTOR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	RAT|RGD=629471|UniProtKB=O70521	Regulator of G-protein signaling 19	IDA	8756726	PubMed	PTHR10845:SF145	REGULATOR OF G-PROTEIN SIGNALING 19
P00048	PI3 kinase pathway	P01199	Galpha	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	IC	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	RAT|RGD=69430|UniProtKB=P32851	Syntaxin-1A	IC	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IC	21157398	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00010	B cell activation	P00398	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IGI	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00840	GPRK	MOUSE|MGI=MGI=1347078|UniProtKB=O70293	G protein-coupled receptor kinase 6	ISS	8288567	PubMed	PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00010	B cell activation	P00402	Jnk	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00034	Integrin signalling pathway	P00917	ELMO	CHICK|Ensembl=ENSGALG00000012093|UniProtKB=Q5ZL97	Uncharacterized protein	ISS	12879077	PubMed	PTHR12771:SF23	ENGULFMENT AND CELL MOTILITY PROTEIN 1
P04393	Ras Pathway	P04573	Elk-1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	IDA	11279280	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00052	TGF-beta signaling pathway	P01276	Co-Smads	DROME|FlyBase=FBgn0011655|UniProtKB=O62609	Mothers against decapentaplegic homolog	TAS	http://flybase.org/reports/FBgn0011655.html	Website	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05913	Enkephalin release	P05974	G-Protein (i)	TAKRU|Ensembl=ENSTRUG00000011297|UniProtKB=H2TV18	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00034	Integrin signalling pathway	P00937	Vinculin	BOVIN|Ensembl=ENSBTAG00000021879|UniProtKB=F1N789	Uncharacterized protein	ISS	14702644	PubMed	PTHR18914:SF1	VINCULIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00047	PDGF signaling pathway	P01173	STAT	MONDO|Ensembl=ENSMODG00000014836|UniProtKB=F7D2D3	Signal transducer and activator of transcription	ISS	8732682	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000022000|UniProtKB=Q9MZL5	Voltage-dependent L-type calcium channel subunit beta-2	IC	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00053	T cell activation	P01300	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00798	Clathrin	BOVIN|Ensembl=ENSBTAG00000010740|UniProtKB=P04975	Clathrin light chain B	ISS	11889126	PubMed	PTHR10639:SF2	CLATHRIN LIGHT CHAIN B
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02920	dCTP deaminase	AQUAE|EnsemblGenome=aq_903|UniProtKB=O67050	tRNA-specific adenosine deaminase	ISS			PTHR11079:SF149	TRNA-SPECIFIC ADENOSINE DEAMINASE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	PANTR|Ensembl=ENSPTRG00000003699|UniProtKB=H2Q3R5	Syntaxin 3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00001	Adrenaline and noradrenaline biosynthesis	P00062	TH	CAEEL|WormBase=WBGene00000296|UniProtKB=P90986	Tyrosine 3-monooxygenase	ISS	12480184	PubMed	PTHR11473:SF15	TYROSINE 3-MONOOXYGENASE
P04375	5HT3 type receptor mediated signaling pathway	P04421	5HT transporter	CANLF|Ensembl=ENSCAFG00000018990|UniProtKB=F1PXA1	Transporter	ISS	14653308	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MACMU|Ensembl=ENSMMUG00000001661|UniProtKB=F7GR69	Uncharacterized protein	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	CANLF|Ensembl=ENSCAFG00000007780|UniProtKB=F1PZH9	Uncharacterized protein	ISS	12181435	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	BOVIN|Ensembl=ENSBTAG00000019832|UniProtKB=G3MZV8	TGF-beta receptor type-2	ISS	9395284	PubMed	PTHR23255:SF55	TGF-BETA RECEPTOR TYPE-2
P00034	Integrin signalling pathway	P00946	Abl	RAT|RGD=1584969|UniProtKB=E9PT20	Tyrosine-protein kinase	ISS	8986783	PubMed	PTHR24418:SF88	TYROSINE-PROTEIN KINASE ABL1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00047	PDGF signaling pathway	P01161	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01356	ERK2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	IC	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P06959	CCKR signaling map	P07228	MAPK1/3	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	RCA	12239223	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00046	Oxidative stress response	P01121	MKK3/6	MONDO|Ensembl=ENSMODG00000006330|UniProtKB=F7AGV5	Uncharacterized protein	RCA			PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MACMU|Ensembl=ENSMMUG00000008877|UniProtKB=F7DTM8	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01336	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	G01533	Bax	MACMU|Ensembl=ENSMMUG00000003907|UniProtKB=F6ZV96	Apoptosis regulator BAX isoform alpha	ISS	11099028	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P04393	Ras Pathway	P04558	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00053	T cell activation	P01300	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00021	FGF signaling pathway	P00646	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	14707121	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CHICK|Ensembl=ENSGALG00000005123|UniProtKB=Q9DEB8	Protein Wnt	TAS	12549854	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P04398	p53 pathway feedback loops 2	P04658	PTEN	CAEEL|WormBase=WBGene00000913|UniProtKB=G5EE01	DAF-18	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00054	Toll receptor signaling pathway	P01381	Ubc13	MACMU|Ensembl=ENSMMUG00000020634|UniProtKB=F6VYS3	Uncharacterized protein	ISS			PTHR43902:SF2	UBIQUITIN-CONJUGATING ENZYME E2 N
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	DANRE|ZFIN=ZDB-GENE-030131-9662|UniProtKB=Q6TEN1	Ras-related protein Rap-1b	ISS	1904317	PubMed	PTHR24070:SF382	RAS-RELATED PROTEIN RAP-1B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04567	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IDA	7565716	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00047	PDGF signaling pathway	P01143	ERK	BOVIN|Ensembl=ENSBTAG00000001014|UniProtKB=A5PKJ4	Mitogen-activated protein kinase 7	ISS	15085193	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00019	Endothelin signaling pathway	P00591	PLCbeta	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	TAS	9332390	PubMed	PTHR10202:SF13	PRESENILIN-2
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	ARATH|TAIR=AT4G17730|UniProtKB=O04378	Syntaxin-23	IC			PTHR19957:SF38	T-SNARE DOMAIN-CONTAINING PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	RAT|Ensembl=ENSRNOG00000058111|UniProtKB=A0A0G2K470	Protein Itga2	ISS	10727440	PubMed	PTHR23220:SF23	INTEGRIN ALPHA-2
P02753	Methionine biosynthesis	P03026	O-Succinyl homoserine lyase	STRCO|Gene=CAC42841|UniProtKB=Q93IX6	Putative cystathionine gamma-synthase	ISS			PTHR11808:SF15	CYSTATHIONINE GAMMA-LYASE
P00006	Apoptosis signaling pathway	P00314	MKK3	MOUSE|MGI=MGI=1346868|UniProtKB=O09110	Dual specificity mitogen-activated protein kinase kinase 3	IDA	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00041	Metabotropic glutamate receptor group I pathway	P01062	mGluR1	RAT|RGD=2742|UniProtKB=P23385	Metabotropic glutamate receptor 1	ISS	12351712	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P04398	p53 pathway feedback loops 2	P04657	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00036	Interleukin signaling pathway	P00995	c-Myc	CANLF|Gene=MYC|UniProtKB=Q28350	Myc proto-oncogene protein	ISS	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00034	Integrin signalling pathway	P00907	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00300	Caspase 7	MACMU|Ensembl=ENSMMUG00000001217|UniProtKB=F7DA15	Uncharacterized protein	ISS	14583630	PubMed	PTHR10454:SF31	CASPASE-7
P00036	Interleukin signaling pathway	P00996	STAT	CANLF|Ensembl=ENSCAFG00000015346|UniProtKB=E2RE22	Signal transducer and activator of transcription	ISS	7514531	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P04393	Ras Pathway	P04569	Cdc42	XENTR|Xenbase=XB-GENE-967585|UniProtKB=Q28BZ0	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P05913	Enkephalin release	P05972	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00005	Angiogenesis	P00219	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00203	Erk	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P06959	CCKR signaling map	G06983	JUN	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	RCA	12239223	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00034	Integrin signalling pathway	P00922	Collagen	MOUSE|MGI=MGI=1277201|UniProtKB=Q9R1N9	Collagen alpha-1(XIII) chain	IDA	10778855	PubMed	PTHR44988:SF1	COLLAGEN ALPHA-1 XIII  CHAIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	RAT|RGD=621528|UniProtKB=Q9JII9	C-X-C chemokine receptor type 3	ISS	12538721	PubMed	PTHR10489:SF671	C-X-C CHEMOKINE RECEPTOR TYPE 3
P05730	Endogenous cannabinoid signaling	P05743	CB1	BOVIN|Ensembl=ENSBTAG00000046006|UniProtKB=G5E6R9	Uncharacterized protein	ISS	9888857	PubMed	PTHR22750:SF47	CANNABINOID RECEPTOR 1
P00020	FAS signaling pathway	P00604	Pro-Caspase8	RAT|RGD=620945|UniProtKB=Q9JHX4	Caspase-8	IGI	8681376	PubMed	PTHR10454:SF162	CASPASE-8
P04393	Ras Pathway	P04559	Rac	MONDO|Ensembl=ENSMODG00000003244|UniProtKB=F6THF0	Uncharacterized protein	ISS	9254684	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P04393	Ras Pathway	P04572	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00049	Parkinson disease	P01219	SAPK	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	BOVIN|Ensembl=ENSBTAG00000037794|UniProtKB=E1BP87	Uncharacterized protein	IC	10938134	PubMed	PTHR13140:SF681	MYOSIN-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	BOVIN|Ensembl=ENSBTAG00000018777|UniProtKB=E1BHU9	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	RAT|RGD=620761|UniProtKB=Q9R172	Neurogenic locus notch homolog protein 3	IDA	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00018	EGF receptor signaling pathway	P00555	MKK4,7	DROME|FlyBase=FBgn0024326|UniProtKB=O61444	MAP kinase kinase 4, isoform A	NAS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00633	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IGI	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00005	Angiogenesis	P00206	Wnt	DANRE|ZFIN=ZDB-GENE-990415-278|UniProtKB=P43446	Protein Wnt-10a	ISS	11266476	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P02738	De novo purine biosynthesis	P02891	GDP kinase	ARATH|TAIR=AT4G11010|UniProtKB=O49203	Nucleoside diphosphate kinase III, chloroplastic/mitochondrial	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00047	PDGF signaling pathway	P01161	Raf	TAKRU|Ensembl=ENSTRUG00000006611|UniProtKB=H2SV11	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04572	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	8920915	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00052	TGF-beta signaling pathway	P01275	P38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00059	p53 pathway	P04635	Sumo-1 ligase	CHICK|Ensembl=ENSGALG00000007971|UniProtKB=Q5ZJM9	Small ubiquitin-related modifier 2	ISS			PTHR10562:SF11	SMALL UBIQUITIN-RELATED MODIFIER 2-RELATED
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	PHYPA|Gene=PHYPADRAFT_60419|UniProtKB=A9TJG9	S-adenosylmethionine synthase	ISS			PTHR11964:SF1	S-ADENOSYLMETHIONINE SYNTHASE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00019	Endothelin signaling pathway	P00578	eNOS	HUMAN|HGNC=7876|UniProtKB=P29474	Nitric oxide synthase, endothelial	ISS	10435050	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	CANLF|Ensembl=ENSCAFG00000013171|UniProtKB=E2RP04	Uncharacterized protein	ISS	6755374	gi	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176910	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01423	p38MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00011	Blood coagulation	P00417	TFPI	MACMU|Ensembl=ENSMMUG00000009448|UniProtKB=Q28864	Tissue factor pathway inhibitor	ISS	5454114	gi	PTHR10083:SF311	TISSUE FACTOR PATHWAY INHIBITOR
P00037	Ionotropic glutamate receptor pathway	P01006	NR2C	MOUSE|MGI=MGI=95822|UniProtKB=Q01098	Glutamate receptor ionotropic, NMDA 2C	ISS	14698601	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000011757|UniProtKB=Q9XT97	Presenilin-1	IDA	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00049	Parkinson disease	P01219	SAPK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	NAS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	12805548	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P05734	Synaptic vesicle trafficking	P05779	Synaptobrevin	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	RCA			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MONDO|Ensembl=ENSMODG00000018204|UniProtKB=F6PGX6	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P05915	Opioid proenkephalin pathway	P05987	peptide F	XENTR|Xenbase=XB-GENE-942760|UniProtKB=F6Y5F6	Uncharacterized protein	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00053	T cell activation	P01336	Jnk	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00046	Oxidative stress response	P01137	MNK1/2	MOUSE|MGI=MGI=894316|UniProtKB=O08605	MAP kinase-interacting serine/threonine-protein kinase 1	IDA	11575158	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00274	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05913	Enkephalin release	P05977	G-Protein (s)	DANRE|ZFIN=ZDB-GENE-040718-134|UniProtKB=Q6DH55	Guanine nucleotide binding protein (G protein), beta polypeptide 3, like	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	DANRE|ZFIN=ZDB-GENE-040520-3|UniProtKB=Q1JPY4	TATA box-binding protein-like protein 2	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00047	PDGF signaling pathway	P01148	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8316835	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00018	EGF receptor signaling pathway	P00547	PP2A	MOUSE|MGI=MGI=2388479|UniProtKB=Q6PD03	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform	ISS	12110603	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00019	Endothelin signaling pathway	P00566	ERK	ARATH|TAIR=AT1G10210|UniProtKB=Q39021	Mitogen-activated protein kinase 1	IGI			PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	CAEEL|WormBase=WBGene00002173|UniProtKB=Q9Y0A1	Inositol 1,4,5-trisphosphate receptor itr-1	IC	12880387	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00019	Endothelin signaling pathway	P00566	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00023	General transcription regulation	P00668	TFIIB	MACMU|Ensembl=ENSMMUG00000015891|UniProtKB=F7BVN4	Transcription factor IIB	ISS			PTHR12458:SF8	CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20
P00010	B cell activation	P00372	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8617307	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P02738	De novo purine biosynthesis	P02891	GDP kinase	ARATH|TAIR=AT4G23900|UniProtKB=Q8LAH8	Nucleoside diphosphate kinase IV, chloroplastic/mitochondrial	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000024992|UniProtKB=F6TUR3	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00019	Endothelin signaling pathway	P00590	IP3 R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P05918	p38 MAPK pathway	P06015	p38gamma	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	RCA	4506785	gi	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04393	Ras Pathway	P04557	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	IDA	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00056	VEGF signaling pathway	P01417	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00053	T cell activation	P01332	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	RCA	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00047	PDGF signaling pathway	P01154	Ras	CHICK|Ensembl=ENSGALG00000028186|UniProtKB=R4GIA5	Uncharacterized protein	ISS			PTHR24070:SF373	RAS-RELATED AND ESTROGEN-REGULATED GROWTH INHIBITOR
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	ARATH|TAIR=AT4G36450|UniProtKB=O23236	Mitogen-activated protein kinase 14	TAS			PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P00004	Alzheimer disease-presenilin pathway	P00162	Pro-BACE-1	MOUSE|MGI=MGI=1346542|UniProtKB=P56818	Beta-secretase 1	IDA	10531052	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MOUSE|MGI=MGI=95821|UniProtKB=Q01097	Glutamate receptor ionotropic, NMDA 2B	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00047	PDGF signaling pathway	P01154	Ras	MONDO|Ensembl=ENSMODG00000025248|UniProtKB=F7F5X1	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00029	Huntington disease	P00811	Arp2/3 complex	MONDO|Ensembl=ENSMODG00000001303|UniProtKB=F7BZM9	Uncharacterized protein (Fragment)	ISS	12932731	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P02738	De novo purine biosynthesis	P02900	AICAR transformylase	BOVIN|Ensembl=ENSBTAG00000019274|UniProtKB=Q0VCK0	Bifunctional purine biosynthesis protein PURH	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00021	FGF signaling pathway	P00644	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IGI	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00025	Hedgehog signaling pathway	P00683	Slimb	MONDO|Ensembl=ENSMODG00000006464|UniProtKB=F7FGS3	Uncharacterized protein	ISS	10074433	PubMed	PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P05731	GABA-B receptor II signaling	P05754	Ggamma	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P02777	Succinate to proprionate conversion	P03163	Methylmalonyl-CoA decarboxylase	BACSU|EnsemblGenome=BSU23920|UniProtKB=P54541	Putative propionyl-CoA carboxylase beta chain	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00045	Notch signaling pathway	P01101	Su(H)	RAT|RGD=1310557|UniProtKB=F1LNW1	Protein Rbpj	ISS	15187023	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P02783	Tryptophan biosynthesis	P03209	Anthranilate phosphoribosyl transferase	YEAST|SGD=S000002762|UniProtKB=P07285	Anthranilate phosphoribosyltransferase	ISS			PTHR43285:SF2	ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE
P00048	PI3 kinase pathway	P01185	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00012	Cadherin signaling pathway	P00465	TCF/LEF	HUMAN|HGNC=6551|UniProtKB=Q9UJU2	Lymphoid enhancer-binding factor 1	ISS	9039917	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00057	Wnt signaling pathway	P01430	p53	MACMU|Ensembl=ENSMMUG00000008639|UniProtKB=P56424	Cellular tumor antigen p53	IDA	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DANRE|ZFIN=ZDB-GENE-030131-1229|UniProtKB=Q6DHS1	Actin, alpha 2, smooth muscle, aorta	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	CANLF|Ensembl=ENSCAFG00000007357|UniProtKB=F1PPK6	Receptor protein serine/threonine kinase	ISS	10683140	PubMed	PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P00053	T cell activation	P01319	PAK	BOVIN|Ensembl=ENSBTAG00000010191|UniProtKB=Q08E52	Serine/threonine-protein kinase PAK 1	ISS	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000017435|UniProtKB=H2QRU2	Uncharacterized protein	ISS	8120095	PubMed	PTHR24026:SF37	PROTOCADHERIN FAT 2
P00047	PDGF signaling pathway	P01153	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00005	Angiogenesis	P00217	STAT3	TAKRU|Ensembl=ENSTRUG00000015348|UniProtKB=H2UQK9	Signal transducer and activator of transcription	ISS	15452141	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MOUSE|MGI=MGI=1346874|UniProtKB=Q61084	Mitogen-activated protein kinase kinase kinase 3	ISS	9006902	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00025	Hedgehog signaling pathway	P00682	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	15313841	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	91232861	PubMed	PTHR24070:SF385	GTPASE HRAS
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00006	Apoptosis signaling pathway	P00301	Apaf-1	PANTR|Ensembl=ENSPTRG00000005335|UniProtKB=H2R1S6	Apoptotic protease-activating factor 1	ISS	14526190	PubMed	PTHR22845:SF5	APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	BOVIN|Ensembl=ENSBTAG00000005968|UniProtKB=F1N0X6	Metalloendopeptidase	ISS	9759503	PubMed	PTHR43978:SF4	TOLLOID-LIKE PROTEIN 1
P00038	JAK/STAT signaling pathway	P01027	STAT	CANLF|Ensembl=ENSCAFG00000015213|UniProtKB=E2RB82	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04398	p53 pathway feedback loops 2	P04663	Mdm2	MACMU|Ensembl=ENSMMUG00000014193|UniProtKB=F7AKR9	Uncharacterized protein	ISS	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00029	Huntington disease	P00778	NMDA receptor	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	IDA	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00050	Plasminogen activating cascade	P01260	pro-MMP-3	MACMU|Ensembl=ENSMMUG00000004249|UniProtKB=F6YVN6	Uncharacterized protein	ISS	3477804	PubMed	PTHR10201:SF215	STROMELYSIN-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00210	eNOS	HUMAN|HGNC=7876|UniProtKB=P29474	Nitric oxide synthase, endothelial	IEP	93055452	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00030	Hypoxia response via HIF activation	P00814	P300	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	IDA	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00015	Circadian clock system	P00505	Cry	PANTR|Ensembl=ENSPTRG00000003537|UniProtKB=H2Q3H0	Uncharacterized protein	ISS	11804325	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00036	Interleukin signaling pathway	P00965	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IC	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02746	Heme biosynthesis	P02970	Coproporphyrinogen oxidase (oxygen independent)	PANTR|Ensembl=ENSPTRG00000009401|UniProtKB=H2QDF3	Radical S-adenosyl methionine domain containing 1	ISS			PTHR13932:SF14	RADICAL S-ADENOSYL METHIONINE DOMAIN-CONTAINING PROTEIN 1, MITOCHONDRIAL
P00011	Blood coagulation	P00422	FIXa	BOVIN|Ensembl=ENSBTAG00000004003|UniProtKB=P00741	Coagulation factor IX	ISS	119769	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P00010	B cell activation	P00385	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00053	T cell activation	P01332	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00269	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	13620175	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8972|UniProtKB=O00750	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	YEAST|SGD=S000005829|UniProtKB=P07258	Carbamoyl-phosphate synthase arginine-specific small chain	ISS			PTHR11405:SF4	CARBAMOYL-PHOSPHATE SYNTHASE ARGININE-SPECIFIC SMALL CHAIN
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	TAS	97442349	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IGI	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00006	Apoptosis signaling pathway	P00274	JNK	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	ISS	11707292	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00015	Circadian clock system	G01501	cry	RAT|RGD=620935|UniProtKB=Q923I8	Cryptochrome-2	IEP	11804325	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	PANTR|Ensembl=ENSPTRG00000016100|UniProtKB=H2QPJ5	Uncharacterized protein	ISS			PTHR24241:SF22	GONADOTROPIN-RELEASING HORMONE RECEPTOR
P00036	Interleukin signaling pathway	P00976	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	RAT|RGD=1562698|UniProtKB=A0A0G2JY08	Protein Myo18a	ISS			PTHR13140:SF421	UNCONVENTIONAL MYOSIN-XVIIIA
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	DROME|FlyBase=FBgn0001123|UniProtKB=P20354	G protein alpha s subunit	ISS	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	ASHGO|EnsemblGenome=AGOS_AGL093W|UniProtKB=Q9HF56	Cell division control protein 42	ISS	4757952	gi	PTHR24072:SF192	CDC42 HOMOLOG
P00047	PDGF signaling pathway	P01142	p90RSK	RAT|RGD=620683|UniProtKB=P67999	Ribosomal protein S6 kinase beta-1	ISS	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00034	Integrin signalling pathway	P00920	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	IDA	11360179	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MOUSE|MGI=MGI=108474|UniProtKB=Q61089	Frizzled-6	TAS	8717036	PubMed	PTHR11309:SF75	FRIZZLED-6
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	DROME|FlyBase=FBgn0024846|UniProtKB=O61443	Mitogen-activated protein kinase 14B	ISS	11707292	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-1712|UniProtKB=Q6PBY0	Guanine nucleotide binding protein (G protein), beta 5	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04393	Ras Pathway	P04544	Grb2	DANRE|ZFIN=ZDB-GENE-040426-1975|UniProtKB=Q6PC73	Growth factor receptor-bound protein 2	ISS	4504111	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00019	Endothelin signaling pathway	P00586	Gq	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00509	Slingshot	DROME|FlyBase=FBgn0029157|UniProtKB=Q6NN85	Protein phosphatase Slingshot	ISS			PTHR10159:SF404	PROTEIN PHOSPHATASE SLINGSHOT
P00006	Apoptosis signaling pathway	P00269	MAPK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	ISS	10851062	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00012	Cadherin signaling pathway	P00477	GSK3beta	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00034	Integrin signalling pathway	P00948	Rho	PANTR|Ensembl=ENSPTRG00000014922|UniProtKB=H2QML4	Uncharacterized protein	ISS	12169092	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	MONDO|Ensembl=ENSMODG00000012761|UniProtKB=F6SJA3	Tyrosine-protein kinase receptor (Fragment)	ISS	249616	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P02756	N-acetylglucosamine metabolism	P03043	N-acetylglucosamine-1-phosphate uridyltransferase	FUSNN|EnsemblGenome=FN1991|UniProtKB=Q8RHM3	Bifunctional protein GlmU	ISS			PTHR43584:SF3	BIFUNCTIONAL PROTEIN GLMU
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04398	p53 pathway feedback loops 2	P04665	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00463	betacatenin	XENTR|Xenbase=XB-GENE-487200|UniProtKB=Q28GC2	Catenin (Cadherin associated protein), beta 1, 88kDa	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00018	EGF receptor signaling pathway	P00558	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01315	Calcineurin	PANTR|Ensembl=ENSPTRG00000002631|UniProtKB=H2Q237	Serine/threonine-protein phosphatase	ISS	12015605	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	TAKRU|Ensembl=ENSTRUG00000001556|UniProtKB=H2RTU5	Uncharacterized protein (Fragment)	IDA			PTHR43893:SF11	SUBFAMILY NOT NAMED
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	MOUSE|MGI=MGI=106677|UniProtKB=Q8BRU6	Synaptic vesicular amine transporter	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P06959	CCKR signaling map	G06985	TACR1	HUMAN|HGNC=11526|UniProtKB=P25103	Substance-P receptor	RCA	20007404	PubMed	PTHR43919:SF2	SUBSTANCE-P RECEPTOR
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	IC	10514528	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00060	Ubiquitin proteasome pathway	P01492	E1	MACMU|Ensembl=ENSMMUG00000008620|UniProtKB=F7FCV8	NEDD8-activating enzyme E1 catalytic subunit isoform 1	ISS			PTHR10953:SF6	NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT
P04393	Ras Pathway	P04541	p90RSK	BOVIN|Ensembl=ENSBTAG00000002015|UniProtKB=G5E5T2	Uncharacterized protein	ISS	6755374	gi	PTHR24351:SF98	RIBOSOMAL PROTEIN S6 KINASE ALPHA-6
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	TAS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00025	Hedgehog signaling pathway	P00682	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00640	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MACMU|Ensembl=ENSMMUG00000009771|UniProtKB=F6ZHU6	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF681	MYOSIN-4
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00046	Oxidative stress response	P01123	Bcl-2	CHICK|Ensembl=ENSGALG00000012885|UniProtKB=Q00709	Apoptosis regulator Bcl-2	TAS	11323415	PubMed	PTHR11256:SF11	APOPTOSIS REGULATOR BCL-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00017	DNA replication	P00534	PCNA	TAKRU|Ensembl=ENSTRUG00000014304|UniProtKB=H2UI14	Proliferating cell nuclear antigen	ISS	12893285	PubMed	PTHR11352:SF0	PROLIFERATING CELL NUCLEAR ANTIGEN
P02775	Salvage pyrimidine ribonucleotides	P03152	Uridine phosphorylase	MOUSE|MGI=MGI=1923904|UniProtKB=Q8CGR7	Uridine phosphorylase 2	ISS			PTHR43691:SF8	URIDINE PHOSPHORYLASE 2
P00060	Ubiquitin proteasome pathway	P01491	E2	DANRE|ZFIN=ZDB-GENE-040426-1291|UniProtKB=Q7T3F3	Ubiquitin-conjugating enzyme E2N-like	ISS			PTHR43902:SF2	UBIQUITIN-CONJUGATING ENZYME E2 N
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000003399|UniProtKB=H2Q383	Phosphoinositide-3-kinase, class 2, alpha polypeptide	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00101	BACE-1	HUMAN|HGNC=934|UniProtKB=Q9Y5Z0	Beta-secretase 2	IDA			PTHR13683:SF262	BETA-SECRETASE 2
P00036	Interleukin signaling pathway	P00990	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00123	CD44 C-terminal fragment	RAT|RGD=2307|UniProtKB=P26051	CD44 antigen	IDA	14871815	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IDA	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	HUMAN|HGNC=1401|UniProtKB=Q02641	Voltage-dependent L-type calcium channel subunit beta-1	ISS	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00983	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P06211	BMP/activin signaling pathway-drosophila	P06250	I-Smad	DROME|FlyBase=FBgn0020493|UniProtKB=Q5U110	Mothers against decapentaplegic homolog	RCA	9335505	PubMed	PTHR13703:SF44	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CANLF|Ensembl=ENSCAFG00000003333|UniProtKB=F1PWT6	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00019	Endothelin signaling pathway	P00566	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04552	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04392	P53 pathway feedback loops 1	G04685	p73DeltaN	HUMAN|HGNC=15979|UniProtKB=Q9H3D4	Tumor protein 63	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00029	Huntington disease	P00775	Rac	DICDI|dictyBase=DDB_G0279605|UniProtKB=P34148	Rho-related protein racB	TAS			PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MACMU|Ensembl=ENSMMUG00000017431|UniProtKB=F7HPP3	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000018563|UniProtKB=F6YMF6	Uncharacterized protein	ISS	12181435	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00558	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IGI	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	176910	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00005	Angiogenesis	P00254	GTPase	MONDO|Ensembl=ENSMODG00000012981|UniProtKB=F7CS91	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00036	Interleukin signaling pathway	P00996	STAT	MONDO|Ensembl=ENSMODG00000014836|UniProtKB=F7D2D3	Signal transducer and activator of transcription	ISS	8732682	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00016	Cytoskeletal regulation by Rho GTPase	P00524	LIMK	MONDO|Ensembl=ENSMODG00000013846|UniProtKB=F6X673	Uncharacterized protein	ISS			PTHR44124:SF1	LIM DOMAIN KINASE 1
P00036	Interleukin signaling pathway	P00990	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	BOVIN|Ensembl=ENSBTAG00000004775|UniProtKB=F1MBY1	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MONDO|Ensembl=ENSMODG00000018065|UniProtKB=F7G485	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00010	B cell activation	P00391	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	DANRE|ZFIN=ZDB-GENE-030616-53|UniProtKB=Q71E60	AMPA receptor subunit GluR3B	ISS	12941441	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-030131-7596|UniProtKB=Q6PBN9	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF26	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT GAMMA-T1
P00034	Integrin signalling pathway	P00907	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	IDA	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01146	Ikk	MOUSE|MGI=MGI=1914544|UniProtKB=Q7TT37	Elongator complex protein 1	ISS			PTHR12747:SF0	ELONGATOR COMPLEX PROTEIN 1
P05918	p38 MAPK pathway	P06026	MEKK4	MOUSE|MGI=MGI=1346875|UniProtKB=O08648	Mitogen-activated protein kinase kinase kinase 4	RCA	602425	OMIM	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00728	RhoGEF	PANTR|Ensembl=ENSPTRG00000011039|UniProtKB=H2QGF2	Uncharacterized protein	ISS	12024019	PubMed	PTHR12673:SF122	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 1
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	ISS	http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00019	Endothelin signaling pathway	P00591	PLCbeta	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00747	Rhodopsin	MOUSE|MGI=MGI=97914|UniProtKB=P15409	Rhodopsin	IDA	1634520	PubMed	PTHR24240:SF15	RHODOPSIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MOUSE|MGI=MGI=87917|UniProtKB=Q01341	Adenylate cyclase type 6	IDA	92357702	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00011	Blood coagulation	P00443	Fibrin polymer cross-linked	RAT|RGD=2604|UniProtKB=P14480	Fibrinogen beta chain	ISS	1706801	gi	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00004	Alzheimer disease-presenilin pathway	P00139	E-cadherin transmembrane fragment	MOUSE|MGI=MGI=88354|UniProtKB=P09803	Cadherin-1	IDA	12834808	PubMed	PTHR24027:SF319	CADHERIN-1
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	DROME|FlyBase=FBgn0028691|UniProtKB=Q7KMP8	26S proteasome regulatory complex subunit p39A	ISS	20351422	PubMed	PTHR10539:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	IC	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00029	Huntington disease	P00810	GAPDH	TRIVA|Gene=TVAG_146910|UniProtKB=A2DHT2	Glyceraldehyde-3-phosphate dehydrogenase	IPI			PTHR43148:SF2	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE C-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	IC	1650351	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00010	B cell activation	P00391	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05994	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00970	Interleukin	MOUSE|MGI=MGI=107364|UniProtKB=Q62386	Interleukin-17A	TAS	11808983	PubMed	PTHR44866:SF1	INTERLEUKIN-17A
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	BOVIN|Ensembl=ENSBTAG00000018989|UniProtKB=A5D7D8	GRM3 protein	ISS	12488551	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00046	Oxidative stress response	P01135	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05915	Opioid proenkephalin pathway	P05985	Mu or Delta receptor	RAT|RGD=3234|UniProtKB=P33535	Mu-type opioid receptor	RCA	12093103	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	RCA	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	DANRE|ZFIN=ZDB-GENE-040808-67|UniProtKB=Q6AZA4	K-ras	ISS	10825661	PubMed	PTHR24070:SF186	GTPASE KRAS
P00029	Huntington disease	P00812	Caspase 3	TAKRU|Ensembl=ENSTRUG00000015915|UniProtKB=H2UUR6	Uncharacterized protein (Fragment)	IDA	9323209	PubMed	PTHR10454:SF198	CASPASE-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	TAS	21291563	gi	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00017	DNA replication	P00531	Pol alpha	MACMU|Ensembl=ENSMMUG00000018433|UniProtKB=F7HF26	DNA polymerase	ISS	20009599	PubMed	PTHR10322:SF21	DNA POLYMERASE ALPHA CATALYTIC SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	XENTR|Xenbase=XB-GENE-494200|UniProtKB=F7CS79	Uncharacterized protein	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ANOGA|EnsemblGenome=AGAP001676|UniProtKB=Q7PXZ8	AGAP001676-PA	IC	14684598	PubMed	PTHR11937:SF368	ACTIN, INDIRECT FLIGHT MUSCLE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	DANRE|ZFIN=ZDB-GENE-030723-4|UniProtKB=Q66I23	Transforming growth factor beta 3	ISS	9759503	PubMed	PTHR11848:SF34	TRANSFORMING GROWTH FACTOR BETA-3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHICK|Ensembl=ENSGALG00000014620|UniProtKB=F1N8P3	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IPI	14526383	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IGI	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00021	FGF signaling pathway	P00629	PP2A	PANTR|Ensembl=ENSPTRG00000003065|UniProtKB=H2Q2S6	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B	ISS			PTHR11871:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B DELTA ISOFORM
P00018	EGF receptor signaling pathway	P00543	ERK1-2	ARATH|TAIR=AT1G18150|UniProtKB=Q9LM33	Mitogen-activated protein kinase 8	ISS			PTHR24055:SF246	MITOGEN-ACTIVATED PROTEIN KINASE 15-RELATED
P00005	Angiogenesis	P00221	JNK1	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00018	EGF receptor signaling pathway	P00554	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	7680960	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	IC	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01143	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	PSEAE|EnsemblGenome=PA0342|UniProtKB=Q9I6F1	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CAEBR|Gene=CBG02161|UniProtKB=A8WS32	Protein CBG02161	ISS	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00019	Endothelin signaling pathway	P00586	Gq	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	CHICK|Ensembl=ENSGALG00000004083|UniProtKB=Q90855	AMPA receptor GluR1/A	ISS	10331083	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT1G07880|UniProtKB=Q9LQQ9	Mitogen-activated protein kinase 13	ISS	9836510	gi	PTHR24055:SF185	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00049	Parkinson disease	P01211	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00045	Notch signaling pathway	P01116	Delta	CANLF|Ensembl=ENSCAFG00000009401|UniProtKB=E2R9U3	Delta-like protein	ISS	11798067	PubMed	PTHR24044:SF320	DELTA-LIKE PROTEIN 4
P00034	Integrin signalling pathway	P00925	MEK	HUMAN|HGNC=6844|UniProtKB=P45985	Dual specificity mitogen-activated protein kinase kinase 4	IDA	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00057	Wnt signaling pathway	P01451	Galpha	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00983	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04547	Ras	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	IDA	22097630	PubMed	PTHR24070:SF189	GTPASE NRAS
P00049	Parkinson disease	P01219	SAPK	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	ISS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	MOUSE|MGI=MGI=95818|UniProtKB=Q61626	Glutamate receptor ionotropic, kainate 5	ISS	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00034	Integrin signalling pathway	P00912	Arp2/3	MACMU|Ensembl=ENSMMUG00000001458|UniProtKB=F7BKH1	Uncharacterized protein	ISS	12963527	gi	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	22533439	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00057	Wnt signaling pathway	P01457	GBeta	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MACMU|Ensembl=ENSMMUG00000019112|UniProtKB=F6T8S6	N-methyl D-aspartate receptor subtype 2B	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04384	Gamma-aminobutyric acid synthesis	P04482	Glutamate decarboxylase	MOUSE|MGI=MGI=95632|UniProtKB=P48318	Glutamate decarboxylase 1	ISS	2247446	PubMed	PTHR11999:SF57	GLUTAMATE DECARBOXYLASE 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=109356|UniProtKB=O09044	Synaptosomal-associated protein 23	IC	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00053	T cell activation	P01332	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00206	Wnt	BOVIN|Ensembl=ENSBTAG00000009217|UniProtKB=F1MEW8	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00056	VEGF signaling pathway	P01411	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=24667|UniProtKB=Q8TD08	Mitogen-activated protein kinase 15	TAS	12787066	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00018	EGF receptor signaling pathway	P00543	ERK1-2	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	IC	8557110	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01472	Histone deacetylase	ARATH|TAIR=AT3G44490|UniProtKB=Q9LXN8	Histone deacetylase 17	ISS	10485845	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P00036	Interleukin signaling pathway	P00985	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	9094314	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00047	PDGF signaling pathway	P01150	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00049	Parkinson disease	P01208	Hsp70	EMENI|EnsemblGenome=CADANIAG00008731|UniProtKB=Q5BBL8	GR78_NEUCR 78 kDa GLUCOSE-REGULATED PROTEIN HOMOLOG (GRP 78) (IMMUNOGLOBULIN HEAVY CHAIN BINDING PROTEIN HOMOLOG) (BIP)	ISS	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00010	B cell activation	P00367	NFAT	RAT|RGD=1308692|UniProtKB=A0A0G2JTY4	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 (Predicted), isoform CRA_b	ISS	12015605	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00018	EGF receptor signaling pathway	P00564	Rac	DICDI|dictyBase=DDB_G0293526|UniProtKB=P34149	Rho-related protein racC	IGI	12932731	PubMed	PTHR24072:SF117	RHO-RELATED PROTEIN RACC
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	BOVIN|Ensembl=ENSBTAG00000009778|UniProtKB=E1BMX0	Uncharacterized protein	ISS	3023884	PubMed	PTHR24070:SF186	GTPASE KRAS
P00017	DNA replication	P00534	PCNA	DANRE|ZFIN=ZDB-GENE-000210-8|UniProtKB=Q9PTP1	Proliferating cell nuclear antigen	ISS	12893285	PubMed	PTHR11352:SF0	PROLIFERATING CELL NUCLEAR ANTIGEN
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00633	Ras	ANOGA|EnsemblGenome=AGAP002219|UniProtKB=Q7QK91	AGAP002219-PA	ISS	10684567	PubMed	PTHR24070:SF385	GTPASE HRAS
P05731	GABA-B receptor II signaling	P05753	Ca channel	RAT|RGD=68942|UniProtKB=O54898	Voltage-dependent T-type calcium channel subunit alpha-1G	ISS	18021322	PubMed	PTHR10037:SF137	VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1G
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	CHICK|Ensembl=ENSGALG00000014365|UniProtKB=F1NIJ8	Uncharacterized protein	ISS	12145413	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00211	GSK3beta	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00057	Wnt signaling pathway	P01446	Calcineurin	NEUCR|EnsemblGenome=EFNCRG00000003441|UniProtKB=P87072	Calcineurin subunit B	IDA	12015605	PubMed	PTHR23056:SF4	PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1
P00047	PDGF signaling pathway	P01173	STAT	CANLF|Ensembl=ENSCAFG00000015346|UniProtKB=E2RE22	Signal transducer and activator of transcription	ISS	7514531	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BOVIN|Ensembl=ENSBTAG00000005714|UniProtKB=Q3ZC07	Actin, alpha cardiac muscle 1	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	DANRE|ZFIN=ZDB-GENE-050417-59|UniProtKB=Q15KE4	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	RCA			PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	MOUSE|MGI=MGI=1339656|UniProtKB=Q61036	Serine/threonine-protein kinase PAK 3	ISS	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P06664	Gonadotropin-releasing hormone receptor pathway	G06892	GnRHR	MOUSE|MGI=MGI=95790|UniProtKB=Q01776	Gonadotropin-releasing hormone receptor	RCA	12629106	PubMed	PTHR24241:SF22	GONADOTROPIN-RELEASING HORMONE RECEPTOR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	BOVIN|Gene=ADCY1|UniProtKB=P19754	Adenylate cyclase type 1	IDA	2491850	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P00010	B cell activation	P00371	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9836512	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01423	p38MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02769	Purine metabolism	P03117	5'-AMP Deaminase	MOUSE|MGI=MGI=1096344|UniProtKB=O08739	AMP deaminase 3	ISS	1420359	PubMed	PTHR11359:SF2	AMP DEAMINASE 3
P00012	Cadherin signaling pathway	P00471	Cadherin	CHICK|Ensembl=ENSGALG00000012917|UniProtKB=Q90762	Cadherin-6	IDA	8120095	PubMed	PTHR24027:SF322	CADHERIN-6
P00059	p53 pathway	P04620	TRAF	PANTR|Ensembl=ENSPTRG00000021578|UniProtKB=H2QY73	TNF receptor-associated factor 2	ISS	8069916	PubMed	PTHR10131:SF21	TNF RECEPTOR-ASSOCIATED FACTOR 2
P00034	Integrin signalling pathway	P00924	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00013	Cell cycle	P00480	Proteasome	SCHPO|PomBase=SPAC607.05|UniProtKB=Q9US13	Probable 26S proteasome regulatory subunit rpn9	ISS	12859888	PubMed	PTHR10539:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13
P00005	Angiogenesis	P00203	Erk	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000009626|UniProtKB=F6ZYQ0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00017	DNA replication	P00536	DNA Topisomerase	HUMAN|HGNC=11989|UniProtKB=P11388	DNA topoisomerase 2-alpha	ISS			PTHR10169:SF46	DNA TOPOISOMERASE 2-ALPHA
P00057	Wnt signaling pathway	P01451	Galpha	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	IDA	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02729	Ascorbate degradation	P02849	L-xylulose kinase	GLOVI|Gene=BAC88722|UniProtKB=Q7NMI5	Gll0781 protein	ISS			PTHR43435:SF2	SUBFAMILY NOT NAMED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	20908895	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00054	Toll receptor signaling pathway	P01369	MKK1	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	94313981	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02738	De novo purine biosynthesis	P02909	GDP reductase	FUSNN|EnsemblGenome=FN0103|UniProtKB=Q8RH17	Ribonucleoside-diphosphate reductase subunit beta	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IDA	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00007	Axon guidance mediated by semaphorins	P00340	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00780	Microtubule	MOUSE|MGI=MGI=107813|UniProtKB=Q9ERD7	Tubulin beta-3 chain	IDA	9454836	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	ISS	1482697	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04574	PLD	RAT|RGD=3349|UniProtKB=P70496	Phospholipase D1	ISS	9307024	PubMed	PTHR18896:SF57	PHOSPHOLIPASE D1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	ORNAN|Ensembl=ENSOANG00000003049|UniProtKB=F7B0P2	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	ARATH|TAIR=AT5G28020|UniProtKB=Q9SXS7	Bifunctional L-3-cyanoalanine synthase/cysteine synthase D2	ISS			PTHR10314:SF97	BIFUNCTIONAL L-3-CYANOALANINE SYNTHASE/CYSTEINE SYNTHASE D1-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	97442349	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=101948|UniProtKB=P48615	Protein Wnt-11	IDA	8717036	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00052	TGF-beta signaling pathway	P01292	RSmads	CHICK|Ensembl=ENSGALG00000009977|UniProtKB=Q56IA0	Mothers against decapentaplegic homolog	ISS	12736218	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	PSEAE|EnsemblGenome=PA1155|UniProtKB=Q9I4I2	Ribonucleoside-diphosphate reductase subunit beta	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00035	Interferon-gamma signaling pathway	P00953	Jak1	DANRE|ZFIN=ZDB-GENE-980526-142|UniProtKB=O12990	Tyrosine-protein kinase JAK1	TAS	11929133	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00056	VEGF signaling pathway	P01408	Akt/PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	XENTR|Xenbase=XB-GENE-957124|UniProtKB=F7BDN8	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04398	p53 pathway feedback loops 2	P04665	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P06002	G-protein	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00034	Integrin signalling pathway	P00944	Actin	MONDO|Ensembl=ENSMODG00000025240|UniProtKB=F7A7I3	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DICDI|dictyBase=DDB_G0283907|UniProtKB=P34099	cAMP-dependent protein kinase catalytic subunit	IC	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00053	T cell activation	P01322	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00056	VEGF signaling pathway	P01414	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	HUMAN|HGNC=1392|UniProtKB=Q15878	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	14507926	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00010	B cell activation	P00371	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04553	PAK	CANLF|Ensembl=ENSCAFG00000004956|UniProtKB=E2REH3	Uncharacterized protein	ISS	14580336	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P06959	CCKR signaling map	P07180	CAS	HUMAN|HGNC=971|UniProtKB=P56945	Breast cancer anti-estrogen resistance protein 1	RCA	11181948	PubMed	PTHR10654:SF15	BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 1
P04371	5-Hydroxytryptamine biosynthesis	P04399	Tryptophan hydroxylase	MOUSE|MGI=MGI=98796|UniProtKB=P17532	Tryptophan 5-hydroxylase 1	ISS	14597720	PubMed	PTHR11473:SF23	TRYPTOPHAN 5-HYDROXYLASE 1
P00025	Hedgehog signaling pathway	P00682	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00021	FGF signaling pathway	P00627	ERK1-2	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01315	Calcineurin	RAT|RGD=3382|UniProtKB=P63329	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	IGI	12091710	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04556	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00029	Huntington disease	P00799	JNK-2	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00056	VEGF signaling pathway	P01425	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	3755548	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00014	Cholesterol biosynthesis	P00498	Hydroxymethyl glutaryl CoA synthase	RAT|RGD=70970|UniProtKB=P17425	Hydroxymethylglutaryl-CoA synthase, cytoplasmic	ISS	123332	gi	PTHR43323:SF4	HYDROXYMETHYLGLUTARYL-COA SYNTHASE, CYTOPLASMIC
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00047	PDGF signaling pathway	P01175	Shc	MOUSE|MGI=MGI=98296|UniProtKB=P98083	SHC-transforming protein 1	ISS	8264585	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00053	T cell activation	P01336	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IGI	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	ECOLI|EcoGene=EG10660|UniProtKB=P00452	Ribonucleoside-diphosphate reductase 1 subunit alpha	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00052	TGF-beta signaling pathway	P01292	RSmads	CAEEL|WormBase=WBGene00006445|UniProtKB=G5EDS9	Dwarfin sma	ISS			PTHR13703:SF44	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	STRPU|EnsemblGenome=SPU_006811|UniProtKB=W4XTQ9	Uncharacterized protein	IC			PTHR13140:SF663	HEAVY CHAIN, UNCONVENTIONAL MYOSIN
P00005	Angiogenesis	P00254	GTPase	SCHPO|PomBase=SPAC1F7.04|UniProtKB=Q09914	GTP-binding protein rho1	ISS			PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	DANRE|ZFIN=ZDB-GENE-020125-4|UniProtKB=F1QKT1	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00056	VEGF signaling pathway	P01411	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00590	IP3 R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00006	Apoptosis signaling pathway	P00321	HSP70	TAKRU|Ensembl=ENSTRUG00000003346|UniProtKB=H2S609	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00019	Endothelin signaling pathway	P00590	IP3 R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	RCA	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=1351345|UniProtKB=P47743	Metabotropic glutamate receptor 8	IDA	9407094	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P05731	GABA-B receptor II signaling	P05760	AC	MACMU|Ensembl=ENSMMUG00000006253|UniProtKB=F7H582	Uncharacterized protein	ISS	93028552	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00049	Parkinson disease	P01226	CDCrel-1	XENTR|Ensembl=ENSXETG00000030888|UniProtKB=F7CL77	Uncharacterized protein (Fragment)	ISS	11078524	PubMed	PTHR18884:SF68	SEPTIN-5
P00047	PDGF signaling pathway	P01167	Ets	MONDO|Ensembl=ENSMODG00000004730|UniProtKB=F6Y1Z2	Uncharacterized protein	ISS	3060801	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00057	Wnt signaling pathway	P01431	LRP5/6	MONDO|Ensembl=ENSMODG00000018237|UniProtKB=F6PG65	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00019	Endothelin signaling pathway	P00566	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	RCA	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MACMU|Ensembl=ENSMMUG00000008653|UniProtKB=F7F4C3	Uncharacterized protein	ISS	10664585	PubMed	PTHR23351:SF6	FOS-RELATED ANTIGEN 1
P00029	Huntington disease	P00807	Actin	BOVIN|Gene=ACTR2|UniProtKB=A7MB62	Actin-related protein 2	ISS	10974003	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00030	Hypoxia response via HIF activation	P00819	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	ARATH|TAIR=AT3G47290|UniProtKB=Q9STZ3	Phosphoinositide phospholipase C 8	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00019	Endothelin signaling pathway	P00589	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IGI	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00366	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MOUSE|MGI=MGI=87909|UniProtKB=P62737	Actin, aortic smooth muscle	IC	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00021	FGF signaling pathway	P00638	PLCgamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	8946911	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000008751|UniProtKB=H2QC89	Uncharacterized protein	ISS	12507995	PubMed	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000009626|UniProtKB=F6ZYQ0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	HUMAN|HGNC=3025|UniProtKB=P21917	D(4) dopamine receptor	IDA	2137198	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00015	Circadian clock system	G01501	cry	DROME|FlyBase=FBgn0025680|UniProtKB=O77059	Cryptochrome-1	IDA	10839367	PubMed	PTHR11455:SF17	CRYPTOCHROME-1
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	XENTR|Xenbase=XB-GENE-1005023|UniProtKB=Q6NVQ9	Fructose-bisphosphate aldolase	ISS	99023741	PubMed	PTHR11627:SF3	FRUCTOSE-BISPHOSPHATE ALDOLASE C
P00006	Apoptosis signaling pathway	P00269	MAPK	ORYSJ|EnsemblGenome=OS06G0699400|UniProtKB=Q5Z859	Mitogen-activated protein kinase 4	ISS	7341300	gi	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MACMU|Ensembl=ENSMMUG00000019112|UniProtKB=F6T8S6	N-methyl D-aspartate receptor subtype 2B	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	ORYSJ|EnsemblGenome=OS03G0130400|UniProtKB=Q10S93	Probable adenylate kinase 1, chloroplastic	ISS			PTHR23359:SF78	SUBFAMILY NOT NAMED
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00053	T cell activation	P01332	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P01483	Mdm2	MOUSE|MGI=MGI=96952|UniProtKB=P23804	E3 ubiquitin-protein ligase Mdm2	IGI	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	IDA	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00053	T cell activation	P01311	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00940	Src	DROME|FlyBase=FBgn0264959|UniProtKB=Q9V9J3	Tyrosine-protein kinase Src42A	IPI	8054685	PubMed	PTHR24418:SF292	TYROSINE-PROTEIN KINASE SRC42A
P00015	Circadian clock system	G01499	per	BOVIN|Ensembl=ENSBTAG00000003889|UniProtKB=F1MDK3	Uncharacterized protein	ISS	12782655	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	9094314	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00048	PI3 kinase pathway	P01177	P110ACT	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	IC	12855688	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00256	PLC-gamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	CHICK|Ensembl=ENSGALG00000006426|UniProtKB=E1BS97	Uncharacterized protein	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00019	Endothelin signaling pathway	P00586	Gq	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00029	Huntington disease	P00786	ARF	ORYSJ|EnsemblGenome=OS08G0248900|UniProtKB=Q6YW27	Os08g0248900 protein	ISS	12932731	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	IDA	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00830	Lipoxygenase	MACMU|Ensembl=ENSMMUG00000030381|UniProtKB=F7EPQ4	Uncharacterized protein	ISS	12432925	PubMed	PTHR11771:SF33	ARACHIDONATE 15-LIPOXYGENASE
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MACMU|Ensembl=ENSMMUG00000009732|UniProtKB=F6ZWP5	Beta-centractin	ISS	14684598	PubMed	PTHR11937:SF195	BETA-CENTRACTIN
P05913	Enkephalin release	P05972	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00139	E-cadherin transmembrane fragment	HUMAN|HGNC=1762|UniProtKB=P22223	Cadherin-3	IDA	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P00010	B cell activation	P00379	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IPI	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00897	SHIP2	RAT|RGD=68396|UniProtKB=Q9WVR3	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	TAS	10381377	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	RAT|RGD=71014|UniProtKB=Q04400	Adenylate cyclase type 5	IDA	93156838	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	DROME|FlyBase=FBgn0004619|UniProtKB=Q03445	Glutamate receptor 1	IC	10331083	PubMed	PTHR18966:SF270	GLUTAMATE RECEPTOR 1-RELATED
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	NAS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00643	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02723	Adenine and hypoxanthine salvage pathway	P02811	Adenosine deaminase	STRCO|EnsemblGenome=CAB77418|UniProtKB=Q9L0L6	Putative adenosine/adenine deaminase	ISS			PTHR43114:SF3	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00899	IRS 1-4	MOUSE|MGI=MGI=99454|UniProtKB=P35569	Insulin receptor substrate 1	ISS	11701440	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00018	EGF receptor signaling pathway	P00548	RKIP	CAEBR|Gene=CBG05964|UniProtKB=A8X180	Protein CBG05964	ISS			PTHR11362:SF44	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IDA	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	BOVIN|Gene=CHRNA3|UniProtKB=Q07263	Neuronal acetylcholine receptor subunit alpha-3	IC	18005395	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MACMU|Ensembl=ENSMMUG00000010266|UniProtKB=F6PV18	Uncharacterized protein	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00053	T cell activation	P01306	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P00059	p53 pathway	G04704	KAI	PANTR|Ensembl=ENSPTRG00000003530|UniProtKB=H2Q3G5	Tetraspanin	ISS	12474542	PubMed	PTHR19282:SF44	CD82 ANTIGEN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00029	Huntington disease	P00807	Actin	XENTR|Xenbase=XB-GENE-491618|UniProtKB=Q6P378	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	CANLF|Ensembl=ENSCAFG00000000132|UniProtKB=J9P309	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00047	PDGF signaling pathway	P01154	Ras	DANRE|ZFIN=ZDB-GENE-040808-67|UniProtKB=Q6AZA4	K-ras	ISS	10825661	PubMed	PTHR24070:SF186	GTPASE KRAS
P05918	p38 MAPK pathway	P06027	CREB	MONDO|Ensembl=ENSMODG00000015970|UniProtKB=F7FD05	Uncharacterized protein	ISS	1354612	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	TAS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01192	p110	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00045	Notch signaling pathway	P01110	Presenilin	CAEEL|WormBase=WBGene00004769|UniProtKB=P52166	Presenilin sel-12	IGI	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00052	TGF-beta signaling pathway	P01284	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_115565|UniProtKB=C3XYD3	Putative uncharacterized protein	ISS			PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DROME|FlyBase=FBgn0011743|UniProtKB=P45891	Actin-like protein 53D	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	MACMU|Ensembl=ENSMMUG00000012470|UniProtKB=F7G0B2	Uncharacterized protein	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00010	B cell activation	P00371	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CANLF|Ensembl=ENSCAFG00000002617|UniProtKB=E2QUL1	Uncharacterized protein	ISS	11319238	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MOUSE|MGI=MGI=1278317|UniProtKB=A4FUQ5	Formyl peptide receptor-related sequence 4	IC			PTHR24225:SF26	FORMYL PEPTIDE RECEPTOR-RELATED SEQUENCE 4
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MOUSE|MGI=MGI=103301|UniProtKB=Q8R0S4	Voltage-dependent L-type calcium channel subunit beta-4	IC			PTHR11824:SF7	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4
P00057	Wnt signaling pathway	P01432	Beta-Catenin	TAKRU|Ensembl=ENSTRUG00000003520|UniProtKB=H2S791	Uncharacterized protein	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	HUMAN|HGNC=4597|UniProtKB=P41594	Metabotropic glutamate receptor 5	ISS	12351712	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P05916	Opioid prodynorphin pathway	P06002	G-protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	10704417	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MOUSE|MGI=MGI=1341867|UniProtKB=Q9R0S2	Matrix metalloproteinase-24	TAS	12834808	PubMed	PTHR10201:SF138	MATRIX METALLOPROTEINASE-24
P00021	FGF signaling pathway	P00641	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1203729|UniProtKB=Q61194	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00925	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	IC	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00029	Huntington disease	P00775	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05913	Enkephalin release	P05974	G-Protein (i)	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04393	Ras Pathway	P04558	p38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04392	P53 pathway feedback loops 1	P04539	p53	HUMAN|HGNC=15979|UniProtKB=Q9H3D4	Tumor protein 63	TAS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00054	Toll receptor signaling pathway	P01368	MKK2	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00011	Blood coagulation	P00426	PC	HUMAN|HGNC=9451|UniProtKB=P04070	Vitamin K-dependent protein C	ISS	4506115	gi	PTHR24278:SF0	VITAMIN K-DEPENDENT PROTEIN C
P02738	De novo purine biosynthesis	P02905	Amidophosphoribosyl transferase	CHICK|Gene=PPAT|UniProtKB=P28173	Amidophosphoribosyltransferase	ISS			PTHR11907:SF18	AMIDOPHOSPHORIBOSYLTRANSFERASE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00052	TGF-beta signaling pathway	P01275	P38	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00046	Oxidative stress response	P01131	MKP5	CAEEL|WormBase=WBGene00017428|UniProtKB=Q19388	Uncharacterized protein	ISS			PTHR10159:SF303	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00552	Ras	MONDO|Ensembl=ENSMODG00000018565|UniProtKB=F7FRS1	Uncharacterized protein	ISS			PTHR24070:SF268	RAS-RELATED PROTEIN M-RAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000013587|UniProtKB=F7AZ16	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF33	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CHICK|Ensembl=ENSGALG00000014539|UniProtKB=F1N861	Uncharacterized protein	ISS	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00006	Apoptosis signaling pathway	P00274	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00053	T cell activation	P01294	NFAT	PANTR|Ensembl=ENSPTRG00000013628|UniProtKB=H2R4F5	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00036	Interleukin signaling pathway	P00990	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00310	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	15210700	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-040718-93|UniProtKB=Q6DGZ5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00047	PDGF signaling pathway	P01149	MNK1/2	BOVIN|Gene=MKNK1|UniProtKB=Q58D94	MAP kinase-interacting serine/threonine-protein kinase 1	ISS	97299868	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=24667|UniProtKB=Q8TD08	Mitogen-activated protein kinase 15	IDA	12787066	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00017	DNA replication	P00528	Primase	MOUSE|MGI=MGI=97758|UniProtKB=P33610	DNA primase large subunit	ISS	8026492	PubMed	PTHR10537:SF3	DNA PRIMASE LARGE SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	GIAIC|EnsemblGenome=GL50803_101291|UniProtKB=A8BEI6	Beta tubulin	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00047	PDGF signaling pathway	P01152	RasGAP	MOUSE|MGI=MGI=1330842|UniProtKB=Q9Z268	RasGAP-activating-like protein 1	ISS	13529338	gi	PTHR10194:SF3	RASGAP-ACTIVATING-LIKE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00564	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00887	IRS 1-4	MOUSE|MGI=MGI=1338009|UniProtKB=Q9Z0Y7	Insulin receptor substrate 4	ISS	5031805	gi	PTHR10614:SF2	INSULIN RECEPTOR SUBSTRATE 4
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	TAS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	MOUSE|MGI=MGI=1346348|UniProtKB=Q9R1C0	Transcription initiation factor TFIID subunit 7	ISS			PTHR12228:SF6	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 7
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=1748|UniProtKB=P12830	Cadherin-1	IDA	8120095	PubMed	PTHR24027:SF319	CADHERIN-1
P00057	Wnt signaling pathway	P01468	APC	RAT|RGD=1308256|UniProtKB=A0A0G2JZW4	Protein Apc2	ISS	10491393	PubMed	PTHR12607:SF3	ADENOMATOUS POLYPOSIS COLI PROTEIN 2
P00056	VEGF signaling pathway	P01423	p38MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00059	p53 pathway	G01579	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00002	Alpha adrenergic receptor signaling pathway	P00078	Alpha1A/1B/1C	CANLF|Ensembl=ENSCAFG00000006805|UniProtKB=F1Q1Q4	Uncharacterized protein	ISS	6323229	PubMed	PTHR24248:SF26	ALPHA-2B ADRENERGIC RECEPTOR
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Ensembl=ENSPTRG00000011042|UniProtKB=H2QGF5	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00057	Wnt signaling pathway	P01451	Galpha	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00114	actin	USTMA|Gene=UMAG_11232|UniProtKB=A0A0D1DMT3	Chromosome 22, whole genome shotgun sequence	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00046	Oxidative stress response	P01135	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00036	Interleukin signaling pathway	P00973	PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00564	Rac	ENTHI|EnsemblGenome=EHI_181250|UniProtKB=C4M5Z7	Rho family GTPase	IGI	97082968	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IGI	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05917	Opioid proopiomelanocortin pathway	P06006	beta-Endorphin	DANRE|ZFIN=ZDB-GENE-030513-2|UniProtKB=Q7ZT18	Pro-opiomelanocortin protein	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Gene=CHRM2|UniProtKB=Q9N2A7	Muscarinic acetylcholine receptor M2 (Fragment)	ISS	12181435	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_56687|UniProtKB=C3YC50	Putative uncharacterized protein	IDA	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	YEAST|SGD=S000003272|UniProtKB=P14681	Mitogen-activated protein kinase KSS1	ISS	11707292	PubMed	PTHR24055:SF338	MITOGEN-ACTIVATED PROTEIN KINASE KSS1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	MONDO|Ensembl=ENSMODG00000007536|UniProtKB=K7E435	Integrin beta	ISS	3487386	PubMed	PTHR10082:SF28	INTEGRIN BETA-1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	PANTR|Ensembl=ENSPTRG00000005632|UniProtKB=H2Q772	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF86	FRIZZLED-10
P00005	Angiogenesis	P00219	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IDA	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00005	Angiogenesis	P00221	JNK1	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04572	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02787	Vitamin B6 metabolism	P03227	Phosphoserine transaminase	HUMAN|HGNC=19129|UniProtKB=Q9Y617	Phosphoserine aminotransferase	TAS	20886743	gi	PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P00019	Endothelin signaling pathway	P00586	Gq	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02725	Allantoin degradation	P02817	Glycerate kinase II	ECOLI|EcoGene=EG11175|UniProtKB=P23524	Glycerate 2-kinase	ISS			PTHR21599:SF8	GLYCERATE 2-KINASE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	IDA	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00052	TGF-beta signaling pathway	P01284	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MACMU|Ensembl=ENSMMUG00000022347|UniProtKB=F6ZCH5	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00005	Angiogenesis	P00208	MEKK1	PANTR|Ensembl=ENSPTRG00000016891|UniProtKB=H2R5K3	Uncharacterized protein	ISS	12049732	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	15621031	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P02753	Methionine biosynthesis	P03024	Homocysteine transmethylase	DEIRA|EnsemblGenome=DR_0966|UniProtKB=Q9RVQ6	5-methyltetrahydrofolate--homocysteine methyltransferase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	RCA	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	CANLF|Ensembl=ENSCAFG00000024151|UniProtKB=E2R795	Tyrosine-protein kinase receptor	ISS	10226785	PubMed	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P05915	Opioid proenkephalin pathway	P05995	proenkephalin	DANRE|ZFIN=ZDB-GENE-030729-31|UniProtKB=A8E7S2	Uncharacterized protein	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	IC	8838325	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00021	FGF signaling pathway	P00624	14-3-3	DROME|FlyBase=FBgn0020238|UniProtKB=P92177	14-3-3 protein epsilon	IGI	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=3765|UniProtKB=P30938	Somatostatin receptor type 5	IDA	12441358	PubMed	PTHR24229:SF20	SOMATOSTATIN RECEPTOR TYPE 5
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	IC	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00582	COX-2	RAT|RGD=620349|UniProtKB=P35355	Prostaglandin G/H synthase 2	IGI	93357029	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00011	Blood coagulation	P00421	alpha1-antitrypsin	MACMU|Ensembl=ENSMMUG00000020426|UniProtKB=F6SEN6	Alpha-1-antitrypsin	ISS	225768	gi	PTHR11461:SF165	ALPHA-1-ANTITRYPSIN-RELATED
P00054	Toll receptor signaling pathway	P01345	IKKalpha	MOUSE|MGI=MGI=99484|UniProtKB=Q60680	Inhibitor of nuclear factor kappa-B kinase subunit alpha	ISS	14499113	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00005	Angiogenesis	P00188	Ets	MOUSE|MGI=MGI=95455|UniProtKB=P27577	Protein C-ets-1	ISS	9157999	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00642	MEK1-2	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00036	Interleukin signaling pathway	P00977	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	G01545	scl-1	CAEEL|WormBase=WBGene00009895|UniProtKB=Q20603	SCP-Like extracellular protein	ISS			PTHR10334:SF182	SCP-LIKE EXTRACELLULAR PROTEIN
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00047	PDGF signaling pathway	P01160	IP3 receptor	CAEEL|WormBase=WBGene00002173|UniProtKB=Q9Y0A1	Inositol 1,4,5-trisphosphate receptor itr-1	ISS	1849282	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P05918	p38 MAPK pathway	P06020	p38delta	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	RCA	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	HUMAN|HGNC=4574|UniProtKB=P48058	Glutamate receptor 4	ISS	12941441	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	MOUSE|MGI=MGI=94924|UniProtKB=P61168	D(2) dopamine receptor	RCA	11861492	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00021	FGF signaling pathway	P00629	PP2A	STRPU|EnsemblGenome=SPU_025182|UniProtKB=W4ZAK5	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	CAEBR|Gene=CBG20206|UniProtKB=A8XX71	Protein CBR-KIN-19	ISS	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00029	Huntington disease	P00807	Actin	DANRE|ZFIN=ZDB-GENE-050410-4|UniProtKB=Q56A35	Actin-related protein 2-B	ISS	10974003	PubMed	PTHR11937:SF149	ACTIN-RELATED PROTEIN 2-A-RELATED
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P02750	Lipoate_biosynthesis	P03004	Lipoate synthase	AQUAE|EnsemblGenome=aq_1355|UniProtKB=O67368	Lipoyl synthase	ISS			PTHR10949:SF0	LIPOYL SYNTHASE, MITOCHONDRIAL
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	IC	12488551	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P04395	Vasopressin synthesis	P04597	Signal Peptide	DANRE|ZFIN=ZDB-GENE-030407-1|UniProtKB=F1QC27	Uncharacterized protein	ISS	3768139	PubMed	PTHR11681:SF14	SUBFAMILY NOT NAMED
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	IC	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P02762	Pentose phosphate pathway	P03071	Ribulose 5-P Isomerase	RAT|RGD=1311377|UniProtKB=D4A7L6	Protein Rpia	RCA			PTHR11934:SF0	RIBOSE-5-PHOSPHATE ISOMERASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000012036|UniProtKB=F7ALP1	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00009	Axon guidance mediated by netrin	P00359	NFAT	MACMU|Ensembl=ENSMMUG00000021843|UniProtKB=F6RNI3	Uncharacterized protein	ISS	12787506	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00049	Parkinson disease	P01242	Casein kinase I	ARATH|TAIR=AT4G08800|UniProtKB=F4JID0	Protein kinase family protein	IDA	11437445	PubMed	PTHR11909:SF298	CASEIN KINASE 1-LIKE PROTEIN 12-RELATED
P00046	Oxidative stress response	P01132	c-jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00029	Huntington disease	P00775	Rac	ASHGO|EnsemblGenome=AGOS_AGL093W|UniProtKB=Q9HF56	Cell division control protein 42	ISS			PTHR24072:SF192	CDC42 HOMOLOG
P00052	TGF-beta signaling pathway	P01286	TGFbeta	RAT|RGD=1304678|UniProtKB=Q1HI69	Growth differentiation factor 1 protein	ISS	9759503	PubMed	PTHR11848:SF151	EMBRYONIC GROWTH/DIFFERENTIATION FACTOR 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	HUMAN|HGNC=5286|UniProtKB=P08908	5-hydroxytryptamine receptor 1A	ISS	2156831	PubMed	PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	IXOSC|EnsemblGenome=ISCW009711|UniProtKB=B7Q3T6	THO complex subunit, putative	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHICK|Ensembl=ENSGALG00000028749|UniProtKB=Q5ZMQ2	Actin, cytoplasmic 2	ISS	11889139	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00048	PI3 kinase pathway	P01202	p85	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02738	De novo purine biosynthesis	P02909	GDP reductase	YEAST|SGD=S000003563|UniProtKB=P09938	Ribonucleoside-diphosphate reductase small chain 1	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00053	T cell activation	P01306	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00037	Ionotropic glutamate receptor pathway	P01015	Glu4	RAT|RGD=61863|UniProtKB=P19493	Glutamate receptor 4	ISS	10331083	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00021	FGF signaling pathway	P00632	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	IGI	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01355	AP1	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Ensembl=ENSGALG00000028612|UniProtKB=F1P3X1	Uncharacterized protein	IEP	89264452	PubMed	PTHR13140:SF728	MYOSIN HEAVY CHAIN, SKELETAL MUSCLE, ADULT
P06587	Nicotine pharmacodynamics pathway	P06597	CDK5	MACMU|Ensembl=ENSMMUG00000020451|UniProtKB=F6VZU3	Uncharacterized protein	ISS	12372285	PubMed	PTHR24056:SF46	CYCLIN-DEPENDENT-LIKE KINASE 5
P00047	PDGF signaling pathway	P01154	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P00034	Integrin signalling pathway	P00920	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	RAT|RGD=3130|UniProtKB=P09416	Myc proto-oncogene protein	IEP	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00057	Wnt signaling pathway	P01454	betaTrCP	BOVIN|Ensembl=ENSBTAG00000007476|UniProtKB=F1MVN1	Uncharacterized protein	ISS	10074433	PubMed	PTHR44038:SF2	F-BOX/WD REPEAT-CONTAINING PROTEIN 1A
P00036	Interleukin signaling pathway	P00970	Interleukin	MOUSE|MGI=MGI=96563|UniProtKB=P15247	Interleukin-9	IC			PTHR16926:SF1	INTERLEUKIN-9
P00049	Parkinson disease	P01234	GRK	HUMAN|HGNC=289|UniProtKB=P25098	Beta-adrenergic receptor kinase 1	IDA	8288567	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MOUSE|MGI=MGI=95821|UniProtKB=Q01097	Glutamate receptor ionotropic, NMDA 2B	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00056	VEGF signaling pathway	P01408	Akt/PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00645	Rac	DICPU|Gene=DICPUDRAFT_55703|UniProtKB=F0ZN94	Putative uncharacterized protein racC	ISS	12932731	PubMed	PTHR24072:SF117	RHO-RELATED PROTEIN RACC
P00037	Ionotropic glutamate receptor pathway	P01020	NSF	MOUSE|MGI=MGI=104560|UniProtKB=P46460	Vesicle-fusing ATPase	ISS	601633	OMIM	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MONDO|Ensembl=ENSMODG00000025248|UniProtKB=F7F5X1	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00019	Endothelin signaling pathway	P00589	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	NAS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00774	Dynein complex	BOVIN|Ensembl=ENSBTAG00000021972|UniProtKB=E1BMG2	Uncharacterized protein	ISS	9454836	PubMed	PTHR10676:SF240	DYNEIN HEAVY CHAIN 5, AXONEMAL
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00048	PI3 kinase pathway	P01202	p85	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00011	Blood coagulation	P00415	Plasmin	HUMAN|HGNC=9071|UniProtKB=P00747	Plasminogen	ISS	4505881	gi	PTHR24261:SF6	PLASMINOGEN
P04397	p53 pathway by glucose deprivation	P04641	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04397	p53 pathway by glucose deprivation	P04641	Akt	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	ISS	12655147	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	ARATH|TAIR=AT5G43900|UniProtKB=Q9LKB9	Myosin-6	IC			PTHR13140:SF256	MYOSIN-10-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00018	EGF receptor signaling pathway	P00540	MKK3,6	XENTR|Xenbase=XB-GENE-944183|UniProtKB=F7EJU0	Uncharacterized protein (Fragment)	ISS			PTHR24361:SF645	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00053	T cell activation	P01311	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=109211|UniProtKB=Q8BWW9	Serine/threonine-protein kinase N2	ISS	10644715	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	CANLF|Ensembl=ENSCAFG00000003409|UniProtKB=E2R7H9	Uncharacterized protein	ISS			PTHR23409:SF20	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00047	PDGF signaling pathway	P01153	GSK3	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00057	Wnt signaling pathway	P01444	Wnt	BRAFL|Gene=BRAFLDRAFT_104698|UniProtKB=C3XYW6	Protein Wnt (Fragment)	IDA	11266476	PubMed	PTHR12027:SF81	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00054	Toll receptor signaling pathway	P01358	ERK1	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00006	Apoptosis signaling pathway	P00269	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04570	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00050	Plasminogen activating cascade	P01245	PAI-1	HUMAN|HGNC=8583|UniProtKB=P05121	Plasminogen activator inhibitor 1	ISS	189578	gi	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00057	Wnt signaling pathway	P01451	Galpha	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IDA	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000002349|UniProtKB=P61267	Syntaxin-1B	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00049	Parkinson disease	P01230	Src kinase	ANOGA|EnsemblGenome=AGAP006510|UniProtKB=Q7Q5D3	Tyrosine-protein kinase	IDA	11078745	PubMed	PTHR24418:SF283	TYROSINE-PROTEIN KINASE SRC64B
P04384	Gamma-aminobutyric acid synthesis	P04482	Glutamate decarboxylase	HUMAN|HGNC=4093|UniProtKB=Q05329	Glutamate decarboxylase 2	ISS	2247446	PubMed	PTHR11999:SF77	GLUTAMATE DECARBOXYLASE 2
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-478663|UniProtKB=F7EG64	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04455	beta-endorphin	XENTR|Xenbase=XB-GENE-483703|UniProtKB=Q5M8F2	Proopiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P02763	Peptidoglycan biosynthesis	P03091	D-alanine-D-alanine ligase	AQUAE|EnsemblGenome=aq_521|UniProtKB=O66806	D-alanine--D-alanine ligase	ISS			PTHR23132:SF12	D-ALANINE--D-ALANINE LIGASE B
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	IDA	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00047	PDGF signaling pathway	P01153	GSK3	MACMU|Ensembl=ENSMMUG00000014597|UniProtKB=F6VAQ6	Glycogen synthase kinase-3 alpha	ISS	11995474	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P05730	Endogenous cannabinoid signaling	P05746	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IC	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IC	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00025	Hedgehog signaling pathway	P00691	CBP	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	RAT|RGD=631406|UniProtKB=Q8CHL0	Frizzled-5	ISS	11212302	PubMed	PTHR11309:SF126	FRIZZLED-5
P00037	Ionotropic glutamate receptor pathway	P00998	stargazin	CHICK|Ensembl=ENSGALG00000003911|UniProtKB=E1C4A6	Voltage-dependent calcium channel gamma subunit	ISS	11140673	PubMed	PTHR12107:SF4	VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-5 SUBUNIT
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	ARATH|TAIR=AT3G10330|UniProtKB=Q9SS44	Transcription initiation factor IIB-2	ISS			PTHR11618:SF37	CYCLIN FAMILY PROTEIN-RELATED
P00005	Angiogenesis	P00219	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00029	Huntington disease	P00807	Actin	TRIAD|EnsemblGenome=TriadG63375|UniProtKB=B3S5E4	Non-muscle actin 6.2	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12676940	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00020	FAS signaling pathway	P00599	Caspase3	HUMAN|HGNC=1504|UniProtKB=P42574	Caspase-3	IGI	9323209	PubMed	PTHR10454:SF198	CASPASE-3
P00029	Huntington disease	P00775	Rac	YEAST|SGD=S000004219|UniProtKB=P19073	Cell division control protein 42	TAS			PTHR24072:SF192	CDC42 HOMOLOG
P04378	Beta2 adrenergic receptor signaling pathway	P04440	Beta2	RAT|RGD=2060|UniProtKB=P10608	Beta-2 adrenergic receptor	ISS	7669252	PubMed	PTHR24248:SF21	BETA-2 ADRENERGIC RECEPTOR
P00050	Plasminogen activating cascade	P01262	pro-uPA	MACMU|Ensembl=ENSMMUG00000009906|UniProtKB=F6YDX7	Uncharacterized protein	ISS	137114	gi	PTHR24264:SF38	UROKINASE-TYPE PLASMINOGEN ACTIVATOR
P04393	Ras Pathway	P04570	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00996	STAT	HUMAN|HGNC=11367|UniProtKB=P51692	Signal transducer and activator of transcription 5B	IC	96210005	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00022	General transcription by RNA polymerase I	P00652	RNA Polymerase I  Complex	BOVIN|Ensembl=ENSBTAG00000033252|UniProtKB=G3MYF3	Uncharacterized protein	ISS	12446911	PubMed	PTHR13946:SF28	DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	BOVIN|Ensembl=ENSBTAG00000020756|UniProtKB=A6QLB8	GSK3A protein	ISS	12086949	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	TAS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00628	JNK1-3	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00036	Interleukin signaling pathway	P00975	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	227170	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PANTR|Ensembl=ENSPTRG00000010369|UniProtKB=H2QF52	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF253	TUBULIN BETA-4A CHAIN
P00006	Apoptosis signaling pathway	P00269	MAPK	CHLRE|EnsemblGenome=CHLREDRAFT_193901|UniProtKB=Q9FXT7	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P02750	Lipoate_biosynthesis	P03004	Lipoate synthase	ARATH|TAIR=AT5G08415|UniProtKB=Q8LEE8	Lipoyl synthase, chloroplastic	ISS			PTHR10949:SF0	LIPOYL SYNTHASE, MITOCHONDRIAL
P02765	Phenylalanine biosynthesis	P03099	Prephenate dehydratase	BACSU|EnsemblGenome=BSU27900|UniProtKB=P21203	Prephenate dehydratase	ISS			PTHR21022:SF0	PREPHENATE DEHYDRATASE-RELATED
P00034	Integrin signalling pathway	P00912	Arp2/3	CANLF|Ensembl=ENSCAFG00000015081|UniProtKB=E2RMT4	Uncharacterized protein	ISS	12932731	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01179	PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	SCHMA|EnsemblGenome=Smp_046600|UniProtKB=G4VLW2	Putative actin-1	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00087	Fe65	MOUSE|MGI=MGI=107765|UniProtKB=Q9QXJ1	Amyloid beta A4 precursor protein-binding family B member 1	IDA	15115822	PubMed	PTHR14058:SF5	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1
P00057	Wnt signaling pathway	P01447	Dishevelled	CANLF|Ensembl=ENSCAFG00000019275|UniProtKB=E2QY91	Uncharacterized protein	ISS	11212302	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P04395	Vasopressin synthesis	P04590	Vasopressin	TAKRU|Ensembl=ENSTRUG00000015631|UniProtKB=H2USP0	Uncharacterized protein	ISS			PTHR11681:SF14	SUBFAMILY NOT NAMED
P00045	Notch signaling pathway	G01541	E(spl)-C genes	RAT|RGD=621340|UniProtKB=Q03062	Transcription factor HES-5	TAS	14973298	PubMed	PTHR10985:SF104	TRANSCRIPTION FACTOR HES-5
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	BOVIN|Ensembl=ENSBTAG00000034854|UniProtKB=F1N246	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	MACMU|Ensembl=ENSMMUG00000014817|UniProtKB=F6VXD8	Uncharacterized protein	ISS	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00048	PI3 kinase pathway	P01196	PDK1	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	9094314	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	8836152	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00060	Ubiquitin proteasome pathway	P01491	E2	MACMU|Ensembl=ENSMMUG00000006351|UniProtKB=F7HC17	Ubiquitin-conjugating enzyme E2 E1 isoform 1	ISS			PTHR24068:SF70	UBIQUITIN-CONJUGATING ENZYME E2 E1
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	IPI	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00034	Integrin signalling pathway	P00912	Arp2/3	PANTR|Ensembl=ENSPTRG00000033819|UniProtKB=H2QV00	Actin related protein 2/3 complex, subunit 1A, 41kDa	ISS	12473693	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	DROME|FlyBase=FBgn0011300|UniProtKB=A1Z7L8	Receptor protein serine/threonine kinase	TAS	http://flybase.org/reports/FBgn0011300.html	Website	PTHR23255:SF71	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	BOVIN|Ensembl=ENSBTAG00000003054|UniProtKB=F1MC23	Tyrosine-protein kinase receptor	ISS	10226785	PubMed	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g188243|UniProtKB=A7SCN8	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00012	Cadherin signaling pathway	P00469	Fer	HUMAN|HGNC=3655|UniProtKB=P16591	Tyrosine-protein kinase Fer	ISS	9742093	PubMed	PTHR24418:SF227	TYROSINE-PROTEIN KINASE FER
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	ARATH|TAIR=AT4G28880|UniProtKB=Q93Z18	Protein CASEIN KINASE I-LIKE 3	ISS	10617630	PubMed	PTHR11909:SF97	PROTEIN CASEIN KINASE I-LIKE 3-RELATED
P00056	VEGF signaling pathway	P01407	Erk	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00040	Metabotropic glutamate receptor group II pathway	G01540	BDNF	PANTR|Ensembl=ENSPTRG00000028696|UniProtKB=Q5IS78	Brain-derived neurotrophic factor	ISS	11408619	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=1762|UniProtKB=P22223	Cadherin-3	IDA	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00035	Interferon-gamma signaling pathway	P00958	PIAS	BOVIN|Ensembl=ENSBTAG00000007833|UniProtKB=F1MMY9	Uncharacterized protein	ISS	8682149	PubMed	PTHR10782:SF12	E3 SUMO-PROTEIN LIGASE PIAS2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00006	Apoptosis signaling pathway	P00321	HSP70	PANTR|Ensembl=ENSPTRG00000029753|UniProtKB=H2RF71	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF223	HEAT SHOCK 70 KDA PROTEIN 1A-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05939	GRK6	RAT|RGD=61986|UniProtKB=P97711	G protein-coupled receptor kinase 6	RCA	8288567	PubMed	PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000000365|UniProtKB=F6R9F4	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000002647|UniProtKB=F7DIB7	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00059	p53 pathway	P04623	CBP	BOVIN|Ensembl=ENSBTAG00000016198|UniProtKB=E1B8D6	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	ARATH|TAIR=AT5G62690|UniProtKB=Q56YW9	Tubulin beta-2 chain	ISS	12932731	PubMed	PTHR11588:SF259	TUBULIN BETA-2 CHAIN-RELATED
P00019	Endothelin signaling pathway	P00587	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00990	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00807	Actin	LEIMA|EnsemblGenome=LmjF.04.1230|UniProtKB=Q9U1E8	Actin	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IC	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8686|UniProtKB=Q9Y5E8	Protocadherin beta-15	IDA	8120095	PubMed	PTHR24028:SF97	PROTOCADHERIN BETA-15
P02728	Arginine biosynthesis	P02846	Ornithine carbamoyl transferase	MYCTU|EnsemblGenome=Rv1656|UniProtKB=P9WIT9	Ornithine carbamoyltransferase	ISS			PTHR11405:SF1	ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-478663|UniProtKB=F7EG64	Protein kinase C delta type	ISS	11880265	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	MACMU|Ensembl=ENSMMUG00000006284|UniProtKB=F7H131	Adenylate kinase 2, mitochondrial	ISS			PTHR23359:SF117	ADENYLATE KINASE 2, MITOCHONDRIAL
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00018	EGF receptor signaling pathway	P00539	14-3-3	ARATH|TAIR=AT1G34760|UniProtKB=Q9S9Z8	14-3-3-like protein GF14 omicron	ISS	10407019	PubMed	PTHR18860:SF32	14-3-3 FAMILY PROTEIN-RELATED
P00047	PDGF signaling pathway	P01151	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	G01532	PolyQ HTT	MOUSE|MGI=MGI=96067|UniProtKB=P42859	Huntingtin	TAS	8268927	PubMed	PTHR10170:SF10	HUNTINGTIN
P00021	FGF signaling pathway	P00623	FGF	XENTR|Xenbase=XB-GENE-484466|UniProtKB=F6ZB49	Fibroblast growth factor	ISS	8576175	PubMed	PTHR11486:SF28	FIBROBLAST GROWTH FACTOR 9
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00047	PDGF signaling pathway	P01161	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00206	Wnt	CANLF|Ensembl=ENSCAFG00000032632|UniProtKB=J9P2Q5	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	ISS	11535291	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00053	T cell activation	P01319	PAK	MACMU|Ensembl=ENSMMUG00000001387|UniProtKB=F7D0B4	Uncharacterized protein	ISS	14580336	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	SULSO|EnsemblGenome=SSO2554|UniProtKB=Q97VQ9	Glutamine synthetase (Glutamate ammonia ligase) (GS). (GlnA-3)	ISS			PTHR43785:SF1	TYPE-1 GLUTAMINE SYNTHETASE 2
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IC	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00048	PI3 kinase pathway	P01185	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	BOVIN|Ensembl=ENSBTAG00000012516|UniProtKB=F1MUT8	Uncharacterized protein	ISS	96032356	PubMed	PTHR11958:SF22	EXCITATORY AMINO ACID TRANSPORTER 5
P00046	Oxidative stress response	P01131	MKP5	HUMAN|HGNC=23481|UniProtKB=Q68J44	Dual specificity phosphatase DUPD1	ISS			PTHR10159:SF114	DUAL SPECIFICITY PHOSPHATASE DUPD1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	IDA	13430383	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00054	Toll receptor signaling pathway	P01375	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	CANLF|Ensembl=ENSCAFG00000010871|UniProtKB=F1PXA0	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04384	Gamma-aminobutyric acid synthesis	P04481	Succinic semialdehyde dehydrogenase	DROME|FlyBase=FBgn0039349|UniProtKB=Q9VBP6	GH21316p	IC	12891648	PubMed	PTHR43353:SF5	SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL
P00054	Toll receptor signaling pathway	P01375	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00049	Parkinson disease	P01238	14-3-3	XENTR|Xenbase=XB-GENE-996375|UniProtKB=F7DY42	Uncharacterized protein	ISS	98119747	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	IDA	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P02728	Arginine biosynthesis	P02840	Argininosuccinate synthase	MYCTU|EnsemblGenome=Rv1658|UniProtKB=P9WPW7	Argininosuccinate synthase	ISS			PTHR11587:SF2	ARGININOSUCCINATE SYNTHASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00019	Endothelin signaling pathway	P00568	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01304	Csk	RAT|RGD=1308800|UniProtKB=P32577	Tyrosine-protein kinase CSK	IDA	11078745	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	TAS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P02738	De novo purine biosynthesis	P02902	ADP reductase	CAEBR|Gene=CBG10154|UniProtKB=A8XAI1	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00053	T cell activation	P01333	cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02922	Orotate phosphoribosyltransferase	CRYNJ|EnsemblGenome=CNG03730|UniProtKB=P0CS95	Orotate phosphoribosyltransferase	ISS			PTHR19278:SF9	URIDINE 5'-MONOPHOSPHATE SYNTHASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	RAT|RGD=3693|UniProtKB=Q01818	Chromaffin granule amine transporter	ISS	92370677	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	G04671	proopiomelanocortin	DANRE|ZFIN=ZDB-GENE-041014-294|UniProtKB=Q5SPP4	Uncharacterized protein	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00004	Alzheimer disease-presenilin pathway	P00117	E-cadherin C-terminal fragment	RAT|RGD=69279|UniProtKB=Q9R0T4	Cadherin-1	IDA	11953314	PubMed	PTHR24027:SF319	CADHERIN-1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00047	PDGF signaling pathway	P01160	IP3 receptor	CAEEL|WormBase=WBGene00002173|UniProtKB=Q9Y0A1	Inositol 1,4,5-trisphosphate receptor itr-1	ISS	11007872	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P02734	Chorismate biosynthesis	P02868	Chorismate synthase	BACSU|EnsemblGenome=BSU22710|UniProtKB=P31104	Chorismate synthase	ISS			PTHR21085:SF0	CHORISMATE SYNTHASE
P00012	Cadherin signaling pathway	P00470	F-actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g169611|UniProtKB=A7SEB1	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	PANTR|Ensembl=ENSPTRG00000028542|UniProtKB=H2R591	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF79	FRIZZLED-9
P00059	p53 pathway	P01480	PTEN	DROME|FlyBase=FBgn0026379|UniProtKB=Q7KMQ6	IP16020p	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P06959	CCKR signaling map	P07108	Caspase-3	HUMAN|HGNC=1504|UniProtKB=P42574	Caspase-3	RCA	15351698	PubMed	PTHR10454:SF198	CASPASE-3
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	TAKRU|Ensembl=ENSTRUG00000003520|UniProtKB=H2S791	Uncharacterized protein	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	RAT|RGD=70911|UniProtKB=P38444	Activin receptor type-2A	TAS	9395284	PubMed	PTHR23255:SF64	ACTIVIN RECEPTOR TYPE-2A
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00053	T cell activation	P01311	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	MOUSE|MGI=MGI=106684|UniProtKB=Q8R090	Chromaffin granule amine transporter	ISS	92370677	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00036	Interleukin signaling pathway	P00973	PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	HUMAN|HGNC=8592|UniProtKB=O75914	Serine/threonine-protein kinase PAK 3	ISS	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	RAT|RGD=2248|UniProtKB=P54287	Voltage-dependent L-type calcium channel subunit beta-3	IC			PTHR11824:SF8	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-3
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00057	Wnt signaling pathway	P01448	CBP	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	IDA	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00046	Oxidative stress response	P01135	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000025240|UniProtKB=F7A7I3	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00047	PDGF signaling pathway	P01155	Jak	BOVIN|Ensembl=ENSBTAG00000012047|UniProtKB=E1BCP6	Tyrosine-protein kinase	ISS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MOUSE|MGI=MGI=87906|UniProtKB=P63260	Actin, cytoplasmic 2	ISS	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	10218114	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00018	EGF receptor signaling pathway	P00547	PP2A	MOUSE|MGI=MGI=2388480|UniProtKB=Q6PD28	Protein Ppp2r5b	ISS	11531413	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IC	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04384	Gamma-aminobutyric acid synthesis	P04480	GABA aminotransferase	DANRE|ZFIN=ZDB-GENE-031006-4|UniProtKB=I3IRW7	Uncharacterized protein	ISS	8133261	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=1309999|UniProtKB=Q922R0	cAMP-dependent protein kinase catalytic subunit PRKX	RCA	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00012	Cadherin signaling pathway	P00477	GSK3beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	IDA	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00017	DNA replication	P00527	Histones	CAEEL|WormBase=WBGene00001946|UniProtKB=Q9U281	Histone H3.3 type 2	ISS	12413958	PubMed	PTHR11426:SF118	HISTONE H3.3 TYPE 2-RELATED
P05730	Endogenous cannabinoid signaling	P05746	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	HUMAN|HGNC=145|UniProtKB=P63267	Actin, gamma-enteric smooth muscle	IC	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00034	Integrin signalling pathway	P00941	Integrin alpha	HUMAN|HGNC=6149|UniProtKB=P11215	Integrin alpha-M	IPI	3487386	PubMed	PTHR23220:SF120	INTEGRIN ALPHA-M
P04398	p53 pathway feedback loops 2	P04653	cdk2	STRPU|EnsemblGenome=SPU_007655|UniProtKB=W4XW48	Uncharacterized protein	ISS			PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	BOVIN|Gene=GLUD1|UniProtKB=P00366	Glutamate dehydrogenase 1, mitochondrial	ISS			PTHR11606:SF13	GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BOVIN|Ensembl=ENSBTAG00000014614|UniProtKB=P62739	Actin, aortic smooth muscle	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02738	De novo purine biosynthesis	P02901	Adenosuccinate lyase	MOUSE|MGI=MGI=103202|UniProtKB=P54822	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	CANLF|Ensembl=ENSCAFG00000001097|UniProtKB=E2RCX6	Uncharacterized protein	ISS	12890691	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00025	Hedgehog signaling pathway	P00682	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MOUSE|MGI=MGI=103301|UniProtKB=Q8R0S4	Voltage-dependent L-type calcium channel subunit beta-4	IC			PTHR11824:SF7	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4
P04393	Ras Pathway	P04572	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00052	TGF-beta signaling pathway	P01292	RSmads	DANRE|ZFIN=ZDB-GENE-991119-8|UniProtKB=Q9I8V2	Mothers against decapentaplegic homolog 1	TAS	9395284	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P00021	FGF signaling pathway	P00640	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00005	Angiogenesis	P00223	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01242	Casein kinase I	MONDO|Ensembl=ENSMODG00000009937|UniProtKB=F6R812	Uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01332	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	IDA	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	RAT|RGD=1588452|UniProtKB=P85108	Tubulin beta-2A chain	ISS	12932731	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IGI	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=88397|UniProtKB=Q9ERZ4	Muscarinic acetylcholine receptor M2	IDA	10069496	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	BOVIN|Ensembl=ENSBTAG00000018705|UniProtKB=F1MPC9	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF291	ADENYLATE CYCLASE TYPE 3
P00018	EGF receptor signaling pathway	P00565	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00223	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P05912	Dopamine receptor mediated signaling pathway	P05963	MAO	XENTR|Xenbase=XB-GENE-5749883|UniProtKB=F6V922	Uncharacterized protein (Fragment)	ISS	90344230	PubMed	PTHR43563:SF2	AMINE OXIDASE  FLAVIN-CONTAINING
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	CHICK|Ensembl=ENSGALG00000007794|UniProtKB=A9YZQ5	Dopamine receptor 2 protein transcript variant 1	ISS	11861492	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00870	IL2	RAT|RGD=3020|UniProtKB=Q06332	Lymphotoxin-alpha	ISS			PTHR11471:SF31	LYMPHOTOXIN-ALPHA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05913	Enkephalin release	P05977	G-Protein (s)	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	BOVIN|Ensembl=ENSBTAG00000019210|UniProtKB=F1MJV4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00047	PDGF signaling pathway	P01145	c-fos	BOVIN|Ensembl=ENSBTAG00000017035|UniProtKB=F6RQY3	Uncharacterized protein	ISS			PTHR12565:SF11	UPSTREAM STIMULATORY FACTOR 2
P00052	TGF-beta signaling pathway	P01292	RSmads	MOUSE|MGI=MGI=1201674|UniProtKB=Q8BUN5	Mothers against decapentaplegic homolog 3	TAS	9395284	PubMed	PTHR13703:SF25	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00012	Cadherin signaling pathway	P00462	Casein kinase II	XENTR|Xenbase=XB-GENE-487924|UniProtKB=F6WVD0	Casein kinase II subunit beta (Fragment)	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00034	Integrin signalling pathway	P00906	Rap1	TAKRU|Ensembl=ENSTRUG00000013947|UniProtKB=H2UFE4	Uncharacterized protein	ISS	8576107	PubMed	PTHR24070:SF194	RAS-RELATED PROTEIN RAP-2B
P00049	Parkinson disease	P01212	p38 MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P06587	Nicotine pharmacodynamics pathway	P06612	CHRNB3	RAT|RGD=621544|UniProtKB=P12391	Neuronal acetylcholine receptor subunit beta-3	TAS	15155845	PubMed	PTHR18945:SF75	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	RAT|RGD=620027|UniProtKB=P08911	Muscarinic acetylcholine receptor M5	TAS	8100450	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00013	Cell cycle	P00479	Cdk4/6	PLAF7|EnsemblGenome=MAL13P1.185|UniProtKB=Q8IDW1	Protein kinase 6	IDA			PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	CHICK|Ensembl=ENSGALG00000027629|UniProtKB=Q5ZJ03	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	MYCTU|EnsemblGenome=Rv3051c|UniProtKB=P9WH75	Ribonucleoside-diphosphate reductase subunit alpha	ISS			PTHR11573:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00021	FGF signaling pathway	P00645	Rac	ARATH|TAIR=AT2G44690|UniProtKB=Q9XGU0	Rac-like GTP-binding protein ARAC9	ISS			PTHR24072:SF160	RAC-LIKE GTP-BINDING PROTEIN ARAC9
P00021	FGF signaling pathway	P00648	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	3045562	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00047	PDGF signaling pathway	P01160	IP3 receptor	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	IC	10571227	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04393	Ras Pathway	P04550	Ral	BOVIN|Ensembl=ENSBTAG00000032021|UniProtKB=A5D977	RALB protein	ISS	7687439	PubMed	PTHR24070:SF199	RAS-RELATED PROTEIN RAL-B
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00047	PDGF signaling pathway	P01160	IP3 receptor	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00629	PP2A	PANTR|Ensembl=ENSPTRG00000003853|UniProtKB=H2Q411	Protein phosphatase 2, regulatory subunit B', beta	ISS	10092233	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MOUSE|MGI=MGI=1351338|UniProtKB=P97772	Metabotropic glutamate receptor 1	IDA	12488551	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00057	Wnt signaling pathway	P01455	Smad4	RAT|RGD=3033|UniProtKB=O70437	Mothers against decapentaplegic homolog 4	IDA	10693808	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	MOUSE|MGI=MGI=1306779|UniProtKB=O88430	C-C motif chemokine 22	IDA	9687523	PubMed	PTHR12015:SF102	C-C MOTIF CHEMOKINE 22
P00021	FGF signaling pathway	P00633	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00052	TGF-beta signaling pathway	P01284	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00546	GAP	ORNAN|Ensembl=ENSOANG00000014753|UniProtKB=F7EPN2	Uncharacterized protein (Fragment)	ISS	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	CHICK|Ensembl=ENSGALG00000004693|UniProtKB=Q5ZJI7	Uncharacterized protein	ISS	12932731	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00015	Circadian clock system	G01497	cry	MACMU|Ensembl=ENSMMUG00000002453|UniProtKB=F7HH05	Cryptochrome-2	ISS	14507900	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CHICK|Gene=WNT8C|UniProtKB=P51030	Protein Wnt-8c	TAS	8717036	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P00049	Parkinson disease	P01208	Hsp70	ARATH|TAIR=AT1G09080|UniProtKB=Q8H1B3	Probable mediator of RNA polymerase II transcription subunit 37b	IDA	12150907	PubMed	PTHR19375:SF215	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 37B-RELATED
P00057	Wnt signaling pathway	P01457	GBeta	ANOGA|EnsemblGenome=AGAP005911|UniProtKB=Q7Q6D4	AGAP005911-PA	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00057	Wnt signaling pathway	P01454	betaTrCP	RAT|RGD=1309121|UniProtKB=A0A0G2JVE0	Protein Fbxw11	ISS	12628165	PubMed	PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P00034	Integrin signalling pathway	P00907	ERK	RAT|RGD=620967|UniProtKB=F1M9D0	Protein Map3k2	ISS			PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P02723	Adenine and hypoxanthine salvage pathway	P02810	Adenine phosphoribosyl transferase	CAEEL|WormBase=WBGene00020557|UniProtKB=P91455	Adenine phosphoribosyltransferase	ISS			PTHR32315:SF3	ADENINE PHOSPHORIBOSYLTRANSFERASE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	BRAFL|Gene=BRAFLDRAFT_120208|UniProtKB=C3YMF1	Putative uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF89	TUBULIN BETA-4 CHAIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P06959	CCKR signaling map	P07054	PKCepsilon	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	RCA	12058027	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	IC	15621031	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00004	Alzheimer disease-presenilin pathway	P00139	E-cadherin transmembrane fragment	HUMAN|HGNC=1748|UniProtKB=P12830	Cadherin-1	IDA	8120095	PubMed	PTHR24027:SF319	CADHERIN-1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00021	FGF signaling pathway	P00624	14-3-3	MACMU|Ensembl=ENSMMUG00000013206|UniProtKB=F6XFG9	14-3-3 protein beta/alpha	ISS	91108808	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	IGI	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IDA	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	IPI	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00021	FGF signaling pathway	P00642	MEK1-2	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00053	T cell activation	P01332	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00371	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00046	Oxidative stress response	P01124	Myc	MOUSE|MGI=MGI=97250|UniProtKB=P01108	Myc proto-oncogene protein	TAS	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00017	DNA replication	P00527	Histones	SCHPO|PomBase=SPAC1834.04|UniProtKB=P09988	Histone H3.1/H3.2	ISS	12413958	PubMed	PTHR11426:SF47	SUBFAMILY NOT NAMED
P00012	Cadherin signaling pathway	P00470	F-actin	CHICK|Ensembl=ENSGALG00000011086|UniProtKB=P68139	Actin, alpha skeletal muscle	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	PANTR|Ensembl=ENSPTRG00000018059|UniProtKB=C7G3M9	Glutamate receptor, metabotropic 4	ISS	9407094	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MOUSE|MGI=MGI=1346873|UniProtKB=Q61083	Mitogen-activated protein kinase kinase kinase 2	ISS	11730323	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00036	Interleukin signaling pathway	P00965	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IC	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01194	S6K	RAT|RGD=620683|UniProtKB=P67999	Ribosomal protein S6 kinase beta-1	IDA	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	MONDO|Ensembl=ENSMODG00000008391|UniProtKB=F7A4H4	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P05918	p38 MAPK pathway	P06042	4E-BP1	CANLF|Ensembl=ENSCAFG00000006154|UniProtKB=F1PZE3	Uncharacterized protein	ISS	12820960	PubMed	PTHR12669:SF14	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00018	EGF receptor signaling pathway	P00546	GAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	20908895	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	HUMAN|HGNC=19239|UniProtKB=Q9BT88	Synaptotagmin-11	RCA			PTHR10024:SF115	SYNAPTOTAGMIN-11
P00005	Angiogenesis	P00233	CSL	RAT|RGD=1310557|UniProtKB=F1LNW1	Protein Rbpj	ISS	12145413	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	ORNAN|Ensembl=ENSOANG00000012083|UniProtKB=F7FPY5	Actin-related protein 2/3 complex subunit 4	ISS	5031595	gi	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	IC	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00034	Integrin signalling pathway	P00931	Integrin beta	BOVIN|Ensembl=ENSBTAG00000009080|UniProtKB=Q8SQB8	Integrin beta-6	IDA	3487386	PubMed	PTHR10082:SF11	INTEGRIN BETA-6
P00029	Huntington disease	P00780	Microtubule	NEUCR|EnsemblGenome=EFNCRG00000003612|UniProtKB=P05220	Tubulin beta chain	IDA	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT1G10210|UniProtKB=Q39021	Mitogen-activated protein kinase 1	ISS	15218451	gi	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P05913	Enkephalin release	P05972	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	188830	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	ORYSJ|EnsemblGenome=OS12G0163700|UniProtKB=Q0IPW3	Os12g0163700 protein	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CANLF|Ensembl=ENSCAFG00000017575|UniProtKB=Q076A5	Myosin-4	ISS	89264452	PubMed	PTHR13140:SF657	MYOSIN-4
P04393	Ras Pathway	P04570	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02734	Chorismate biosynthesis	P02873	Shikimate dehydrogenase	ARATH|TAIR=AT3G06350|UniProtKB=Q9SQT8	Bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic	ISS			PTHR21089:SF1	BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE/SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC
P00052	TGF-beta signaling pathway	P01292	RSmads	HUMAN|HGNC=6774|UniProtKB=O15198	Mothers against decapentaplegic homolog 9	TAS	9395284	PubMed	PTHR13703:SF41	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 9
P00020	FAS signaling pathway	P00599	Caspase3	MOUSE|MGI=MGI=107739|UniProtKB=P70677	Caspase-3	ISS	11675509	PubMed	PTHR10454:SF198	CASPASE-3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	ISS	8262392	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00025	Hedgehog signaling pathway	P00692	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MOUSE|MGI=MGI=1927469|UniProtKB=Q9QZB0	Regulator of G-protein signaling 17	IDA	8756726	PubMed	PTHR10845:SF196	REGULATOR OF G-PROTEIN SIGNALING 17
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MOUSE|MGI=MGI=87937|UniProtKB=P34971	Beta-1 adrenergic receptor	IDA	12063255	PubMed	PTHR24248:SF54	BETA-1 ADRENERGIC RECEPTOR
P00022	General transcription by RNA polymerase I	P00652	RNA Polymerase I  Complex	YEAST|SGD=S000006214|UniProtKB=P22138	DNA-directed RNA polymerase I subunit RPA135	ISS	15691654	PubMed	PTHR20856:SF5	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA2
P00021	FGF signaling pathway	P00634	MEKK1-5	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS	9305639	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05915	Opioid proenkephalin pathway	P05995	proenkephalin	MOUSE|MGI=MGI=104629|UniProtKB=P22005	Proenkephalin-A	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00029	Huntington disease	P00786	ARF	PANTR|Ensembl=ENSPTRG00000005350|UniProtKB=H2Q6P9	ADP-ribosylation factor-like 1	ISS	11752622	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	RCA	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00006	Apoptosis signaling pathway	P00313	IKK	MACMU|Ensembl=ENSMMUG00000008351|UniProtKB=F7HRV5	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	TAKRU|Ensembl=ENSTRUG00000009259|UniProtKB=H2TF39	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	DROME|FlyBase=FBgn0004611|UniProtKB=P25455	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II	ISS	12860966	PubMed	PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT1G01560|UniProtKB=Q9LMM5	Mitogen-activated protein kinase 11	IDA	10851062	PubMed	PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00059	p53 pathway	P04612	HDAC1	MOUSE|MGI=MGI=3704479|UniProtKB=D3YYI8	Histone deacetylase	IDA	12665570	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P00047	PDGF signaling pathway	P01160	IP3 receptor	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	IDA	98269030	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CAEEL|WormBase=WBGene00001679|UniProtKB=P17343	Guanine nucleotide-binding protein subunit beta-1	IC	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00056	VEGF signaling pathway	P01423	p38MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00059	p53 pathway	G04694	p110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01179	PKB	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00291	MEKK1	PANTR|Ensembl=ENSPTRG00000016891|UniProtKB=H2R5K3	Uncharacterized protein	ISS	8940199	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00059	p53 pathway	P01480	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P02776	Serine glycine biosynthesis	P03160	Phosphoglycerate dehydrogenase	DEIRA|EnsemblGenome=DR_1291|UniProtKB=Q9RUU0	D-3-phosphoglycerate dehydrogenase	ISS			PTHR42938:SF9	FORMATE DEHYDROGENASE 1-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00034	Integrin signalling pathway	P00948	Rho	XENTR|Xenbase=XB-GENE-478301|UniProtKB=Q6NVL3	Ras homolog gene family, member B	ISS	13679859	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IDA	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00934	VASP	CANLF|Gene=VASP|UniProtKB=P50551	Vasodilator-stimulated phosphoprotein	IPI	8836115	PubMed	PTHR11202:SF12	VASODILATOR-STIMULATED PHOSPHOPROTEIN
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00038	JAK/STAT signaling pathway	P01027	STAT	BOVIN|Gene=STAT3|UniProtKB=P61635	Signal transducer and activator of transcription 3	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	HUMAN|HGNC=4401|UniProtKB=O14775	Guanine nucleotide-binding protein subunit beta-5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00021	FGF signaling pathway	P00642	MEK1-2	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00059	p53 pathway	P01486	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	ANOGA|EnsemblGenome=AGAP007698|UniProtKB=Q5TX47	AGAP007698-PB	ISS			PTHR19957:SF41	SYNTAXIN-1A
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01143	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	PANTR|Ensembl=ENSPTRG00000039733|UniProtKB=H2RDP9	Actin-related protein 2/3 complex subunit 4	ISS	9230079	PubMed	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	4506785	gi	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	IDA	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00030	Hypoxia response via HIF activation	P00819	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	G06680	c-fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	RCA	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	MOUSE|MGI=MGI=1917675|UniProtKB=Q8C4X2	Casein kinase I isoform gamma-3	ISS	11437445	PubMed	PTHR11909:SF151	CASEIN KINASE I ISOFORM GAMMA-3
P00004	Alzheimer disease-presenilin pathway	P00131	HAC1	CANLF|Ensembl=ENSCAFG00000006444|UniProtKB=E2QVW6	Uncharacterized protein	ISS			PTHR44028:SF1	TRIPARTITE MOTIF-CONTAINING PROTEIN 3
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	ISS	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	CAEEL|WormBase=WBGene00004769|UniProtKB=P52166	Presenilin sel-12	IDA	7566091	PubMed	PTHR10202:SF13	PRESENILIN-2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05923	beta-ARR2	CANLF|Ensembl=ENSCAFG00000015905|UniProtKB=E2QUH6	Uncharacterized protein	ISS	9388255	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	ISS	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00034	Integrin signalling pathway	P00906	Rap1	CHICK|Ensembl=ENSGALG00000009927|UniProtKB=Q5ZHX1	Ras-related protein Rap-1b	ISS	1904317	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P02740	De novo pyrimidine ribonucleotides biosythesis	P02922	Orotate phosphoribosyltransferase	DEIRA|EnsemblGenome=DR_0447|UniProtKB=Q9RX68	Orotate phosphoribosyltransferase	ISS			PTHR19278:SF9	URIDINE 5'-MONOPHOSPHATE SYNTHASE
P02738	De novo purine biosynthesis	P02905	Amidophosphoribosyl transferase	SCHPO|PomBase=SPAC4D7.08c|UniProtKB=P41390	Amidophosphoribosyltransferase	ISS			PTHR11907:SF0	AMIDOPHOSPHORIBOSYLTRANSFERASE
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P02755	Methylmalonyl pathway	P03033	Propionyl-CoA carboxylase	MYCTU|EnsemblGenome=Rv3280|UniProtKB=P9WQH7	Probable propionyl-CoA carboxylase beta chain 5	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P00054	Toll receptor signaling pathway	P01368	MKK2	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10755300	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00021	FGF signaling pathway	P00641	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	10514528	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00047	PDGF signaling pathway	P01161	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00005	Angiogenesis	P00204	PLD	RAT|RGD=3350|UniProtKB=P70498	Phospholipase D2	ISS	9538008	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	CANLF|Gene=PSEN1|UniProtKB=Q6RH31	Presenilin-1	ISS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	IDA	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	TAS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00729	Goalpha	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	IDA	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04393	Ras Pathway	P04567	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	IDA	129387	gi	PTHR10048:SF14	PI-3 KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	MONBE|Gene=11217|UniProtKB=A9V8J8	Predicted protein	ISS	9753452	PubMed	PTHR23050:SF245	AT16150P-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00034	Integrin signalling pathway	P00906	Rap1	HUMAN|HGNC=9861|UniProtKB=P10114	Ras-related protein Rap-2a	IC	8576107	PubMed	PTHR24070:SF221	RAS-RELATED PROTEIN RAP-2A
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	ORNAN|Ensembl=ENSOANG00000004790|UniProtKB=F7FMV0	Serine/threonine-protein phosphatase	ISS	8392016	PubMed	PTHR11668:SF204	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-GAMMA CATALYTIC SUBUNIT
P00036	Interleukin signaling pathway	P00976	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00021	FGF signaling pathway	P00637	MKK4,7	CHICK|Ensembl=ENSGALG00000001001|UniProtKB=F1P3T1	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00019	Endothelin signaling pathway	P00586	Gq	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	BOVIN|Ensembl=ENSBTAG00000013958|UniProtKB=G5E5G9	Uncharacterized protein	ISS			PTHR24361:SF345	SERINE/THREONINE-PROTEIN KINASE PAK 4
P04393	Ras Pathway	P04546	GSK3	HUMAN|HGNC=4616|UniProtKB=P49840	Glycogen synthase kinase-3 alpha	IDA	183955	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00047	PDGF signaling pathway	P01143	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	21071228	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04397	p53 pathway by glucose deprivation	P04641	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00012	Cadherin signaling pathway	P00466	EGFR	PANTR|Ensembl=ENSPTRG00000009100|UniProtKB=H2QCV1	Receptor protein-tyrosine kinase	ISS	4758298	gi	PTHR24416:SF137	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2
P00010	B cell activation	P00397	IKK	CANLF|Ensembl=ENSCAFG00000009588|UniProtKB=E2RNA9	Uncharacterized protein	ISS	14499113	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00021	FGF signaling pathway	P00644	p38	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	IGI	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00018	EGF receptor signaling pathway	P00558	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000009626|UniProtKB=F6ZYQ0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02728	Arginine biosynthesis	P02841	argininosuccinate lyase	BACSU|EnsemblGenome=BSU29440|UniProtKB=O34858	Argininosuccinate lyase	ISS			PTHR43814:SF1	ARGININOSUCCINATE LYASE
P00029	Huntington disease	P00807	Actin	PHYPA|Gene=PHYPADRAFT_225906|UniProtKB=A9TVP1	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	HUMAN|HGNC=704|UniProtKB=O15143	Actin-related protein 2/3 complex subunit 1B	ISS	12963527	gi	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	HUMAN|HGNC=4616|UniProtKB=P49840	Glycogen synthase kinase-3 alpha	IDA	2164470	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05731	GABA-B receptor II signaling	P05752	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P02785	Valine biosynthesis	P03216	Acetolactate synthase	YEAST|SGD=S000004714|UniProtKB=P07342	Acetolactate synthase catalytic subunit, mitochondrial	ISS			PTHR18968:SF13	ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00796	Kainate receptor	MOUSE|MGI=MGI=95816|UniProtKB=B1AS29	Glutamate receptor ionotropic, kainate 3	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	TAKRU|Ensembl=ENSTRUG00000016241|UniProtKB=H2UX35	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF305	PROTEIN KINASE C
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	RCA	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01153	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00629	PP2A	XENTR|Xenbase=XB-GENE-6076030|UniProtKB=F7DNP9	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B (Fragment)	ISS	12191994	PubMed	PTHR11871:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B GAMMA ISOFORM
P00006	Apoptosis signaling pathway	P00269	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Ensembl=ENSPTRG00000016548|UniProtKB=H2QQC5	Uncharacterized protein	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P05915	Opioid proenkephalin pathway	P05994	G-protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05731	GABA-B receptor II signaling	P05754	Ggamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00624	14-3-3	RAT|RGD=61998|UniProtKB=P35213	14-3-3 protein beta/alpha	ISS	10407019	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	XENTR|GeneID=394982|UniProtKB=P20399	Actin, alpha cardiac muscle 2	ISS	10974003	PubMed	PTHR11937:SF263	ACTIN
P00059	p53 pathway	P04633	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01438	PP2A	MACMU|Ensembl=ENSMMUG00000000186|UniProtKB=F7ANY1	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04392	P53 pathway feedback loops 1	P04539	p53	HUMAN|HGNC=11998|UniProtKB=P04637	Cellular tumor antigen p53	TAS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00057	Wnt signaling pathway	P01458	Protein Kinase C	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	11554554	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00022	General transcription by RNA polymerase I	P00652	RNA Polymerase I  Complex	SCHPO|PomBase=SPBP23A10.07|UniProtKB=Q9P7X8	Probable DNA-directed RNA polymerase I subunit RPA2	ISS	15691654	PubMed	PTHR20856:SF5	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA2
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00038	JAK/STAT signaling pathway	P01029	Serine kinase	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS			PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02738	De novo purine biosynthesis	P02891	GDP kinase	MOUSE|MGI=MGI=1930182|UniProtKB=Q9WV85	Nucleoside diphosphate kinase 3	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	IPI	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00045	Notch signaling pathway	P01117	Neuralized	RAT|RGD=1307021|UniProtKB=A0A096MJM7	Neuralized-like (Drosophila) (Predicted), isoform CRA_b	RCA			PTHR12429:SF13	E3 UBIQUITIN-PROTEIN LIGASE NEURL1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00034	Integrin signalling pathway	P00906	Rap1	BOVIN|Ensembl=ENSBTAG00000014710|UniProtKB=P62833	Ras-related protein Rap-1A	ISS	8576107	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	CANLF|Ensembl=ENSCAFG00000018170|UniProtKB=E2RPM8	Tyrosine-protein kinase receptor	ISS	14500580	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P00036	Interleukin signaling pathway	P00976	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02731	Biotin biosynthesis	P02858	8-Amino-7-oxononanoate synthase	BACTN|EnsemblGenome=BT_0870|UniProtKB=Q8A9E5	8-amino-7-oxononanoate synthase	ISS			PTHR13693:SF77	8-AMINO-7-OXONONANOATE SYNTHASE
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	ISS	http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02783	Tryptophan biosynthesis	P03209	Anthranilate phosphoribosyl transferase	METAC|EnsemblGenome=MA_2989|UniProtKB=Q8TLP5	Anthranilate phosphoribosyltransferase	ISS			PTHR43285:SF2	ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	IDA	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00047	PDGF signaling pathway	P01168	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	14526383	PubMed	PTHR10048:SF14	PI-3 KINASE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	DEIRA|EnsemblGenome=DR_1687|UniProtKB=Q9RTR9	Glutamyl-Q tRNA(Asp) synthetase	ISS			PTHR43311:SF1	GLUTAMYL-Q TRNA ASP  SYNTHETASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	ORNAN|Ensembl=ENSOANG00000004342|UniProtKB=F6S3B9	Uncharacterized protein	ISS	12562507	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00557	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	TAKRU|Ensembl=ENSTRUG00000009851|UniProtKB=H2TJ90	Uncharacterized protein	IGI	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01177	P110ACT	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	ORYSJ|EnsemblGenome=OS02G0120800|UniProtKB=Q6ZHA3	Rac-like GTP-binding protein 6	ISS	21948222	PubMed	PTHR24072:SF261	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01181	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00034	Integrin signalling pathway	P00938	Cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	PANTR|Ensembl=ENSPTRG00000020039|UniProtKB=H2R9W1	Uncharacterized protein	ISS	12135927	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MOUSE|MGI=MGI=1306784|UniProtKB=O35740	Cbp/p300-interacting transactivator 2	TAS	9865691	PubMed	PTHR17045:SF7	CBP/P300-INTERACTING TRANSACTIVATOR 2
P00054	Toll receptor signaling pathway	P01370	TAK1	MACMU|Ensembl=ENSMMUG00000006512|UniProtKB=F7H6S1	Mitogen-activated protein kinase kinase kinase 7 isoform B	ISS	10683140	PubMed	PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P00010	B cell activation	P00402	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00059	p53 pathway	P04633	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00629	PP2A	TAKRU|Ensembl=ENSTRUG00000008018|UniProtKB=H2T5N4	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MOUSE|MGI=MGI=108409|UniProtKB=O08899	Regulator of G-protein signaling 4	ISS	8756726	PubMed	PTHR10845:SF184	REGULATOR OF G-PROTEIN SIGNALING 4
P02787	Vitamin B6 metabolism	P03244	Pyridoxal kinase	HUMAN|HGNC=8819|UniProtKB=O00764	Pyridoxal kinase	IDA	15082224	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	G06680	c-fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	RCA	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	BOVIN|Ensembl=ENSBTAG00000000469|UniProtKB=P67774	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00552	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P00034	Integrin signalling pathway	P00944	Actin	TAKRU|Ensembl=ENSTRUG00000005447|UniProtKB=P68142	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF354	SUBFAMILY NOT NAMED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00019	Endothelin signaling pathway	P00577	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00059	p53 pathway	G01574	ARF	HUMAN|HGNC=1787|UniProtKB=P42771	Cyclin-dependent kinase inhibitor 2A	IDA	12082609	PubMed	PTHR24148:SF47	CYCLIN-DEPENDENT KINASE 4 INHIBITOR B-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MONDO|Ensembl=ENSMODG00000024440|UniProtKB=F7DJJ2	Muscarinic acetylcholine receptor	ISS			PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P05918	p38 MAPK pathway	P05921	MKP5	MONDO|Ensembl=ENSMODG00000004672|UniProtKB=F6U725	Uncharacterized protein	ISS	11856337	PubMed	PTHR10159:SF299	DUAL SPECIFICITY PROTEIN PHOSPHATASE 10
P00029	Huntington disease	P00807	Actin	HUMAN|HGNC=17780|UniProtKB=Q562R1	Beta-actin-like protein 2	IDA	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P04393	Ras Pathway	P04556	Raf	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P02749	Leucine biosynthesis	P03000	Branched chain amino acid aminotransferase	MACMU|Ensembl=ENSMMUG00000010079|UniProtKB=F6ZG15	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF39	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, MITOCHONDRIAL
P00005	Angiogenesis	P00181	SHP2	MOUSE|MGI=MGI=96055|UniProtKB=P29351	Tyrosine-protein phosphatase non-receptor type 6	ISS			PTHR19134:SF65	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 6
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	HUMAN|HGNC=129|UniProtKB=P68133	Actin, alpha skeletal muscle	IC	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00012	Cadherin signaling pathway	P00470	F-actin	NEUCR|EnsemblGenome=EFNCRG00000003893|UniProtKB=P78711	Actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04453	ACTH	MACMU|Ensembl=ENSMMUG00000016463|UniProtKB=F7GBI0	Uncharacterized protein	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P04397	p53 pathway by glucose deprivation	P04641	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	PANTR|Ensembl=ENSPTRG00000017389|UniProtKB=H2R334	Uncharacterized protein	ISS	12181435	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	HUMAN|HGNC=2452|UniProtKB=P48730	Casein kinase I isoform delta	IDA	10617630	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00047	PDGF signaling pathway	P01142	p90RSK	PANTR|Ensembl=ENSPTRG00000003957|UniProtKB=H2Q486	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	HUMAN|HGNC=6692|UniProtKB=Q07954	Prolow-density lipoprotein receptor-related protein 1	IDA	11907044	PubMed	PTHR44025:SF2	PROLOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01160	IP3 receptor	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00057	Wnt signaling pathway	P01465	Ggamma	XENTR|Xenbase=XB-GENE-961282|UniProtKB=Q6DF43	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00005	Angiogenesis	P00207	Crk	HUMAN|HGNC=2362|UniProtKB=P46108	Adapter molecule crk	ISS	8649368	PubMed	PTHR19969:SF8	ADAPTER MOLECULE CRK
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014262|UniProtKB=F7BYS8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00021	FGF signaling pathway	P00640	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00973	PKB	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00777	CBP	ARATH|TAIR=AT1G55970|UniProtKB=Q9LG11	Histone acetyltransferase HAC4	IDA	8413673	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	RAT|RGD=2025|UniProtKB=P68136	Actin, alpha skeletal muscle	ISS	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00269	MAPK	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF330	SUBFAMILY NOT NAMED
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	MACMU|Ensembl=ENSMMUG00000015240|UniProtKB=F6VUY3	Uncharacterized protein	ISS	11431030	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05731	GABA-B receptor II signaling	P05754	Ggamma	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00006	Apoptosis signaling pathway	P00274	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00029	Huntington disease	P00780	Microtubule	MOUSE|MGI=MGI=107861|UniProtKB=Q7TMM9	Tubulin beta-2A chain	ISS	12932731	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IDA	21157398	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	RCA	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00048	PI3 kinase pathway	P01179	PKB	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00018	EGF receptor signaling pathway	P00559	MEK1-2	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00127	APP	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	IC	87218499	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P05730	Endogenous cannabinoid signaling	P05748	mGluR	CANLF|Ensembl=ENSCAFG00000004381|UniProtKB=J9JH96	Uncharacterized protein	ISS	92317054	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00048	PI3 kinase pathway	P01199	Galpha	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00627	ERK1-2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04396	Vitamin D metabolism and pathway	P04603	1alpha-Hydroxylase	PANTR|Ensembl=ENSPTRG00000005149|UniProtKB=H2Q6C4	Uncharacterized protein	ISS	11013342	PubMed	PTHR24291:SF3	25-HYDROXYVITAMIN D-1 ALPHA HYDROXYLASE, MITOCHONDRIAL
P00005	Angiogenesis	P00203	Erk	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00990	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=14268|UniProtKB=Q9HCL0	Protocadherin-18	ISS	8120095	PubMed	PTHR24028:SF9	PROTOCADHERIN-18
P00011	Blood coagulation	P00457	Thrombomodulin	HUMAN|HGNC=11784|UniProtKB=P07204	Thrombomodulin	ISS	4507483	gi	PTHR24036:SF5	THROMBOMODULIN
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=1561991|UniProtKB=A0A096MJW8	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF51	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P05917	Opioid proopiomelanocortin pathway	P06007	alpha-MSH	BOVIN|Ensembl=ENSBTAG00000007897|UniProtKB=P01190	Pro-opiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	DANRE|ZFIN=ZDB-GENE-980605-30|UniProtKB=Q9YHE8	Transcription factor 7-like 1-A	TAS	9118222	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06766	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	RCA	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04397	p53 pathway by glucose deprivation	P04641	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	DICDI|dictyBase=DDB_G0288319|UniProtKB=O96626	Actin-related protein 2/3 complex subunit 5	ISS	12473693	PubMed	PTHR12644:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00006	Apoptosis signaling pathway	P00318	PKCs	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00020	FAS signaling pathway	P00620	CytochromeC	ORYSJ|EnsemblGenome=OS05G0301700|UniProtKB=Q0DJC3	Os05g0301700 protein	IGI	15163634	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	TAS	98269030	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	IDA	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00054	Toll receptor signaling pathway	G01550	Gene trancription	RAT|RGD=620349|UniProtKB=P35355	Prostaglandin G/H synthase 2	ISS	14684611	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IGI	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00705	Gsalpha	HUMAN|HGNC=4388|UniProtKB=P38405	Guanine nucleotide-binding protein G(olf) subunit alpha	IDA	6309844	PubMed	PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00047	PDGF signaling pathway	P01174	Rho	RAT|RGD=1566260|UniProtKB=F1M287	Protein Srgap1	ISS			PTHR14166:SF15	SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000015241|UniProtKB=Q5IS72	D(3) dopamine receptor	ISS	2039532	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00021	FGF signaling pathway	P00627	ERK1-2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04395	Vasopressin synthesis	P04597	Signal Peptide	TAKRU|Ensembl=ENSTRUG00000015413|UniProtKB=H2UR30	Uncharacterized protein	ISS	3768139	PubMed	PTHR11681:SF13	SUBFAMILY NOT NAMED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	BRAFL|Gene=BRAFLDRAFT_87235|UniProtKB=C3ZEV9	Putative uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00036	Interleukin signaling pathway	P00990	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MOUSE|MGI=MGI=98179|UniProtKB=P10833	Ras-related protein R-Ras	ISS	7997267	PubMed	PTHR24070:SF245	RAS-RELATED PROTEIN R-RAS
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00056	VEGF signaling pathway	P01417	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05731	GABA-B receptor II signaling	P05758	K channel	MACMU|Ensembl=ENSMMUG00000007096|UniProtKB=F7ERG6	G protein-activated inward rectifier potassium channel 1	ISS	12374786	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00012	Cadherin signaling pathway	P00470	F-actin	PHYPA|Gene=PHYPADRAFT_198730|UniProtKB=Q6TYS2	Actin 1	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00049	Parkinson disease	P01222	Ubc6	MOUSE|MGI=MGI=2153608|UniProtKB=Q6P073	Ubiquitin-conjugating enzyme E2 J2	TAS	12859888	PubMed	PTHR43972:SF1	UBIQUITIN-CONJUGATING ENZYME E2 J2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	MOUSE|MGI=MGI=103249|UniProtKB=P62204	Calmodulin	ISS	3885394	PubMed	PTHR23050:SF311	CALMODULIN
P04393	Ras Pathway	P04571	Tiam1	HUMAN|HGNC=11805|UniProtKB=Q13009	T-lymphoma invasion and metastasis-inducing protein 1	ISS	11130063	PubMed	PTHR22826:SF88	T-LYMPHOMA INVASION AND METASTASIS-INDUCING PROTEIN 1
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=88354|UniProtKB=P09803	Cadherin-1	IDA	12834808	PubMed	PTHR24027:SF319	CADHERIN-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IDA	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00034	Integrin signalling pathway	P00916	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IPI	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00037	Ionotropic glutamate receptor pathway	P00999	PSD95	MOUSE|MGI=MGI=3613677|UniProtKB=D3YZU1	SH3 and multiple ankyrin repeat domains protein 1	ISS	20020275	PubMed	PTHR24135:SF3	SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN 1
P02788	Xanthine and guanine salvage pathway	P03249	Guanine deaminase	SCHPO|PomBase=SPCC1672.03c|UniProtKB=O14057	Probable guanine deaminase	ISS			PTHR11271:SF6	GUANINE DEAMINASE
P02746	Heme biosynthesis	P02974	Uroporphyrinogen-III synthase	MOUSE|MGI=MGI=98917|UniProtKB=P51163	Uroporphyrinogen-III synthase	ISS			PTHR12390:SF0	UROPORPHYRINOGEN-III SYNTHASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00018	EGF receptor signaling pathway	P00558	SOS	DROME|FlyBase=FBgn0001965|UniProtKB=P26675	Protein son of sevenless	ISS	8479536	PubMed	PTHR23113:SF99	PROTEIN SON OF SEVENLESS
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01437	TCF	BOVIN|Ensembl=ENSBTAG00000010111|UniProtKB=F1MJS2	Uncharacterized protein	ISS	12356903	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05916	Opioid prodynorphin pathway	P06002	G-protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00045	Notch signaling pathway	P01103	Next	PANTR|Ensembl=ENSPTRG00000010617|UniProtKB=H2QFL8	Notch 3	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00020	FAS signaling pathway	P00601	c-Jun	XENTR|Xenbase=XB-GENE-482228|UniProtKB=F6RYL1	Uncharacterized protein	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00019	Endothelin signaling pathway	P00570	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04657	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00036	Interleukin signaling pathway	P00965	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	XENTR|Xenbase=XB-GENE-1005779|UniProtKB=F7E3I6	Uncharacterized protein	ISS	2039532	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P04396	Vitamin D metabolism and pathway	P04607	FDX	RAT|RGD=1561264|UniProtKB=D4A8N2	Protein Fdx1l	ISS			PTHR23426:SF45	ADRENODOXIN-LIKE PROTEIN, MITOCHONDRIAL
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	CANLF|Ensembl=ENSCAFG00000011733|UniProtKB=E2R5J6	Protein-serine/threonine kinase	RCA			PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P00053	T cell activation	P01312	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05918	p38 MAPK pathway	P06031	p38alpha	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	RCA	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DICDI|dictyBase=DDB_G0283907|UniProtKB=P34099	cAMP-dependent protein kinase catalytic subunit	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P05731	GABA-B receptor II signaling	P05755	Gbeta	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P02761	Pantothenate biosynthesis	P03066	Aspartate decarboxylase	DEIRA|EnsemblGenome=DR_0718|UniProtKB=Q9RWF1	Aspartate 1-decarboxylase	ISS			PTHR21012:SF0	ASPARTATE 1-DECARBOXYLASE
P04393	Ras Pathway	P04557	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01322	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IDA	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00219	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	TAS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00057	Wnt signaling pathway	P01457	GBeta	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00047	PDGF signaling pathway	P01161	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00587	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01219	SAPK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00053	T cell activation	P01322	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01300	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IDA	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CAEEL|WormBase=WBGene00006798|UniProtKB=O16000	Syntaxin-1A homolog	IC			PTHR19957:SF210	SYNTAXIN-1A HOMOLOG
P00047	PDGF signaling pathway	P01160	IP3 receptor	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04393	Ras Pathway	P04563	Ets	MOUSE|MGI=MGI=95455|UniProtKB=P27577	Protein C-ets-1	ISS	15579511	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00012	Cadherin signaling pathway	P00466	EGFR	RAT|RGD=620486|UniProtKB=Q62956	Receptor tyrosine-protein kinase erbB-4	ISS	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	RAT|RGD=2747|UniProtKB=P35349	Metabotropic glutamate receptor 6	ISS	9407094	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00029	Huntington disease	P00786	ARF	TAKRU|Ensembl=ENSTRUG00000011714|UniProtKB=H2TY29	Uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00008	Axon guidance mediated by Slit/Robo	P00355	Rho	TRIAD|EnsemblGenome=TriadG20369|UniProtKB=B3RIM6	Putative uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00007	Axon guidance mediated by semaphorins	P00330	CRAM	MONDO|Ensembl=ENSMODG00000015761|UniProtKB=F6ZT50	Uncharacterized protein	ISS	10851247	PubMed	PTHR11647:SF58	DIHYDROPYRIMIDINASE-RELATED PROTEIN 5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IDA	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00021	FGF signaling pathway	P00636	FGFR1-4	BOVIN|Ensembl=ENSBTAG00000015457|UniProtKB=A4IFL5	Fibroblast growth factor receptor	ISS	2544996	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P00045	Notch signaling pathway	P01110	Presenilin	XENTR|Xenbase=XB-GENE-481916|UniProtKB=F6YF14	Presenilin	ISS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00005	Angiogenesis	P00206	Wnt	MACMU|Ensembl=ENSMMUG00000001325|UniProtKB=F7BGU5	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=23112|UniProtKB=Q8TDW7	Protocadherin Fat 3	ISS	8120095	PubMed	PTHR24026:SF49	PROTOCADHERIN FAT 3
P04393	Ras Pathway	P04547	Ras	DANRE|ZFIN=ZDB-GENE-040808-67|UniProtKB=Q6AZA4	K-ras	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00057	Wnt signaling pathway	P01443	Phospholipase C	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IDA	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00005	Angiogenesis	P00207	Crk	ORNAN|Ensembl=ENSOANG00000006947|UniProtKB=F7E9T7	Uncharacterized protein	ISS	8649368	PubMed	PTHR19969:SF9	CRK-LIKE PROTEIN
P00036	Interleukin signaling pathway	P00965	ERK	HUMAN|HGNC=6879|UniProtKB=Q16659	Mitogen-activated protein kinase 6	IC	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CIOIN|Ensembl=ENSCING00000000848|UniProtKB=F6SCP4	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00005	Angiogenesis	P00206	Wnt	CHICK|Gene=WNT2B|UniProtKB=Q98SN7	Protein Wnt-2b	ISS	11266476	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	DANRE|ZFIN=ZDB-GENE-020125-4|UniProtKB=F1QKT1	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IDA	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00047	PDGF signaling pathway	P01154	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	87226391	PubMed	PTHR24070:SF385	GTPASE HRAS
P00029	Huntington disease	P00778	NMDA receptor	CHICK|Ensembl=ENSGALG00000008898|UniProtKB=F1P2J9	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00021	FGF signaling pathway	P00644	p38	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04398	p53 pathway feedback loops 2	P04665	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00318	PKCs	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00283	A1	CHICK|Ensembl=ENSGALG00000006511|UniProtKB=Q9W6F2	Protein A1	ISS	10090728	PubMed	PTHR11256:SF10	BCL-2-RELATED PROTEIN A1
P04393	Ras Pathway	P04553	PAK	BOVIN|Ensembl=ENSBTAG00000010191|UniProtKB=Q08E52	Serine/threonine-protein kinase PAK 1	ISS	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	MOUSE|MGI=MGI=88448|UniProtKB=Q60847	Collagen alpha-1(XII) chain	IC	10778855	PubMed	PTHR45047:SF2	COLLAGEN ALPHA-1 XII  CHAIN
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04376	5HT4 type receptor mediated signaling pathway	P04426	K+ channel	HUMAN|HGNC=6278|UniProtKB=O14649	Potassium channel subfamily K member 3	ISS	15282272	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P04392	P53 pathway feedback loops 1	P04536	Mdm2	HUMAN|HGNC=6973|UniProtKB=Q00987	E3 ubiquitin-protein ligase Mdm2	IGI	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00539	14-3-3	CANLF|Ensembl=ENSCAFG00000003386|UniProtKB=F6Y478	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P00021	FGF signaling pathway	P00646	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	2842690	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P02747	Histidine biosynthesis	P02987	ATP phosphoribosyl transferase	BACSU|EnsemblGenome=BSU34920|UniProtKB=O34520	ATP phosphoribosyltransferase	ISS			PTHR21403:SF4	ATP PHOSPHORIBOSYLTRANSFERASE
P00047	PDGF signaling pathway	P01143	ERK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00583	cPLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	MOUSE|MGI=MGI=99473|UniProtKB=Q8BWG8	Beta-arrestin-1	ISS	4757780	gi	PTHR11792:SF22	BETA-ARRESTIN-1
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	RAT|RGD=2034|UniProtKB=P26770	Adenylate cyclase type 4	IGI	1946437	PubMed	PTHR11920:SF286	ADENYLATE CYCLASE TYPE 4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	RAT|RGD=2738|UniProtKB=Q00960	Glutamate receptor ionotropic, NMDA 2B	IC	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P02770	Pyridoxal phosphate salvage pathway	P03121	Pyridoxal kinase	ECOLI|EcoGene=EG13940|UniProtKB=P77150	Pyridoxal kinase PdxY	ISS	11677609	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	CHICK|Ensembl=ENSGALG00000008339|UniProtKB=E1BQS9	Uncharacterized protein	ISS	11431030	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00053	T cell activation	P01322	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000009085|UniProtKB=H2RDQ2	Uncharacterized protein	ISS	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00010	B cell activation	P00398	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IGI	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00566	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01465	Ggamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00006	Apoptosis signaling pathway	P00273	p53	MOUSE|MGI=MGI=98834|UniProtKB=P02340	Cellular tumor antigen p53	ISS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00012	Cadherin signaling pathway	P00470	F-actin	MOUSE|MGI=MGI=87904|UniProtKB=P60710	Actin, cytoplasmic 1	IC	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	RCA			PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P05915	Opioid proenkephalin pathway	P05990	K+ channel	HUMAN|HGNC=6278|UniProtKB=O14649	Potassium channel subfamily K member 3	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00048	PI3 kinase pathway	P01182	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	TAS	15528206	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00053	T cell activation	P01307	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00235	c-Fos	BOVIN|Ensembl=ENSBTAG00000004322|UniProtKB=O77628	Proto-oncogene c-Fos	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00019	Endothelin signaling pathway	P00586	Gq	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00587	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00638	PLCgamma	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	ISS	10704417	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P04398	p53 pathway feedback loops 2	G04711	SIAH-1	MOUSE|MGI=MGI=108063|UniProtKB=Q06985	E3 ubiquitin-protein ligase SIAH1B	ISS	14985507	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00004	Alzheimer disease-presenilin pathway	P00125	Ire-1 C-terminal fragment	RAT|RGD=1559716|UniProtKB=A0A0G2K2H4	Protein Ern1	ISS	10619423	PubMed	PTHR13954:SF17	SERINE/THREONINE-PROTEIN KINASE/ENDORIBONUCLEASE IRE1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=98329|UniProtKB=P30935	Somatostatin receptor type 3	IDA	12441358	PubMed	PTHR24229:SF42	SOMATOSTATIN RECEPTOR TYPE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	HUMAN|HGNC=145|UniProtKB=P63267	Actin, gamma-enteric smooth muscle	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00048	PI3 kinase pathway	P01199	Galpha	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00035	Interferon-gamma signaling pathway	P00956	SOCS	HUMAN|HGNC=19392|UniProtKB=Q8WXH5	Suppressor of cytokine signaling 4	TAS	15032587	PubMed	PTHR44282:SF2	SUPPRESSOR OF CYTOKINE SIGNALING 4
P00006	Apoptosis signaling pathway	P00285	Diva	RAT|RGD=621015|UniProtKB=Q99M66	Bcl-2-like protein 10	ISS			PTHR11256:SF47	BCL-2-LIKE PROTEIN 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	HUMAN|HGNC=10631|UniProtKB=Q8NHW4	C-C motif chemokine 4-like	ISS			PTHR12015:SF103	C-C MOTIF CHEMOKINE 4-RELATED
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	ORYSJ|EnsemblGenome=OS03G0223400|UniProtKB=P14654	Glutamine synthetase cytosolic isozyme 1-2	ISS			PTHR20852:SF78	SUBFAMILY NOT NAMED
P00010	B cell activation	P00376	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00047	PDGF signaling pathway	P01160	IP3 receptor	CAEEL|WormBase=WBGene00002173|UniProtKB=Q9Y0A1	Inositol 1,4,5-trisphosphate receptor itr-1	ISS	12880387	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00053	T cell activation	P01332	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Ensembl=ENSBTAG00000018989|UniProtKB=A5D7D8	GRM3 protein	ISS	20012997	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P02729	Ascorbate degradation	P02849	L-xylulose kinase	BACTN|EnsemblGenome=BT_0350|UniProtKB=Q8AAW2	Xylulose kinase (Xylulokinase)	ISS			PTHR43095:SF5	SUBFAMILY NOT NAMED
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	NAS	97320448	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DANRE|ZFIN=ZDB-GENE-000322-1|UniProtKB=Q9I8V1	Actin, alpha 1, skeletal muscle	IDA	11889126	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00029	Huntington disease	P00811	Arp2/3 complex	PANTR|Ensembl=ENSPTRG00000019449|UniProtKB=H2QV01	Actin related protein 2/3 complex, subunit 1B, 41kDa	ISS	12473693	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00019	Endothelin signaling pathway	P00589	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00277	Bi1	MOUSE|MGI=MGI=99682|UniProtKB=Q9D2C7	Bax inhibitor 1	ISS			PTHR23291:SF34	BAX INHIBITOR 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P02772	Pyruvate metabolism	P03141	Citrate Synthetase	CANLF|Ensembl=ENSCAFG00000000115|UniProtKB=F1PV92	Citrate synthase	ISS	2337600	PubMed	PTHR11739:SF8	CITRATE SYNTHASE, MITOCHONDRIAL
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00048	PI3 kinase pathway	P01194	S6K	MOUSE|MGI=MGI=1927343|UniProtKB=Q9Z1M4	Ribosomal protein S6 kinase beta-2	IDA	15116068	PubMed	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00004	Alzheimer disease-presenilin pathway	P00167	CD44 transmembrane fragment	MOUSE|MGI=MGI=88338|UniProtKB=P15379	CD44 antigen	IDA	14871815	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MOUSE|MGI=MGI=104589|UniProtKB=P63268	Actin, gamma-enteric smooth muscle	IDA	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00048	PI3 kinase pathway	P01202	p85	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	PANTR|Ensembl=ENSPTRG00000012554|UniProtKB=H2QIU8	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF58	ACTIVIN RECEPTOR TYPE-1C
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	MACMU|Ensembl=ENSMMUG00000017022|UniProtKB=F7HQZ9	Uncharacterized protein	ISS	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00053	T cell activation	P01304	Csk	MACMU|Ensembl=ENSMMUG00000015267|UniProtKB=F7GRP2	Tyrosine-protein kinase	ISS	12665526	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	MYCTU|EnsemblGenome=LH57_20445|UniProtKB=O69719	tRNA-specific adenosine deaminase	ISS			PTHR11079:SF149	TRNA-SPECIFIC ADENOSINE DEAMINASE
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	ORYSJ|EnsemblGenome=OS04G0165700|UniProtKB=Q7XS58	Cysteine synthase	ISS			PTHR10314:SF80	BIFUNCTIONAL L-3-CYANOALANINE SYNTHASE/CYSTEINE SYNTHASE C1, MITOCHONDRIAL
P00012	Cadherin signaling pathway	P00474	Wnt	BOVIN|Ensembl=ENSBTAG00000022671|UniProtKB=F1MZV4	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	8687401	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01472	Histone deacetylase	MONDO|Ensembl=ENSMODG00000017455|UniProtKB=F6Z5R3	Uncharacterized protein (Fragment)	ISS	12665570	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000000289|UniProtKB=F7A9T0	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	MONDO|Ensembl=ENSMODG00000020977|UniProtKB=F6S5B1	Uncharacterized protein (Fragment)	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00021	FGF signaling pathway	P00641	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04393	Ras Pathway	P04563	Ets	RAT|RGD=2583|UniProtKB=P41156	Protein C-ets-1	IDA	9157999	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00021	FGF signaling pathway	P00624	14-3-3	MONDO|Ensembl=ENSMODG00000010174|UniProtKB=F6TA21	Uncharacterized protein	ISS	5803225	gi	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P02728	Arginine biosynthesis	P02846	Ornithine carbamoyl transferase	GIAIC|EnsemblGenome=GL50803_10311|UniProtKB=E2RTT6	Ornithine carbamoyltransferase	ISS			PTHR11405:SF1	ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	SYNY3|Gene=BAA17764|UniProtKB=P73717	tRNA-specific adenosine deaminase	ISS			PTHR11079:SF149	TRNA-SPECIFIC ADENOSINE DEAMINASE
P00019	Endothelin signaling pathway	P00570	PKA	CRYNJ|EnsemblGenome=CNA05510|UniProtKB=Q5KNS1	cAMP-dependent protein kinase regulatory subunit	IGI	188830	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	TAKRU|Ensembl=ENSTRUG00000011517|UniProtKB=H2TWL9	Uncharacterized protein (Fragment)	ISS	10331083	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00057	Wnt signaling pathway	P01451	Galpha	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00010	B cell activation	P00402	Jnk	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00023	General transcription regulation	P00669	TFIIEalpha	PANTR|Ensembl=ENSPTRG00000015273|UniProtKB=H2QN66	General transcription factor IIE, polypeptide 1, alpha 56kDa	ISS	189962	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00010	B cell activation	P00371	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	CAEEL|WormBase=WBGene00003774|UniProtKB=G5EGQ9	NMDA class glutamate Receptor	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04398	p53 pathway feedback loops 2	P04657	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00005	Angiogenesis	P00235	c-Fos	BOVIN|Ensembl=ENSBTAG00000004322|UniProtKB=O77628	Proto-oncogene c-Fos	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00053	T cell activation	P01303	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8235613	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00872	Rac	MACMU|Ensembl=ENSMMUG00000021075|UniProtKB=F7GY91	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04398	p53 pathway feedback loops 2	P04657	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02738	De novo purine biosynthesis	P02891	GDP kinase	SULSO|EnsemblGenome=SSO0230|UniProtKB=Q980Q7	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00052	TGF-beta signaling pathway	P01288	FKBP12	HUMAN|HGNC=21376|UniProtKB=Q5VVH2	Peptidyl-prolyl cis-trans isomerase	ISS			PTHR10516:SF301	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MOUSE|MGI=MGI=106212|UniProtKB=Q8BMN3	Neuronal acetylcholine receptor subunit beta-3	IC	15155845	PubMed	PTHR18945:SF75	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-3
P00005	Angiogenesis	P00254	GTPase	RAT|RGD=1304965|UniProtKB=A0A0G2K6E0	Protein Rhoc	ISS	12090470	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	G01546	Cyclin d	RAT|RGD=68384|UniProtKB=P39948	G1/S-specific cyclin-D1	ISS	12356903	PubMed	PTHR10177:SF67	G1/S-SPECIFIC CYCLIN-D1
P00045	Notch signaling pathway	P01103	Next	MOUSE|MGI=MGI=99460|UniProtKB=Q61982	Neurogenic locus notch homolog protein 3	IC	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04393	Ras Pathway	P04566	Stat 1/3	MACMU|Ensembl=ENSMMUG00000010707|UniProtKB=F7G8G5	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00019	Endothelin signaling pathway	P00589	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00005	Angiogenesis	P00211	GSK3beta	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	P00562	p38	CAEEL|WormBase=WBGene00004056|UniProtKB=Q8MXI4	Mitogen-activated protein kinase pmk-2	ISS	11707292	PubMed	PTHR24055:SF154	MITOGEN-ACTIVATED PROTEIN KINASE PMK-2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02913	Thymidylate synthase	BACSU|EnsemblGenome=BSU21820|UniProtKB=P11044	Thymidylate synthase 2	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	BOVIN|Ensembl=ENSBTAG00000015670|UniProtKB=E1B7J7	Uncharacterized protein	ISS	11259591	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P05913	Enkephalin release	P05972	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BOVIN|Ensembl=ENSBTAG00000009217|UniProtKB=F1MEW8	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	CAEEL|WormBase=WBGene00004958|UniProtKB=Q01608	Presenilin spe-4	TAS	8755489	PubMed	PTHR10202:SF17	PRESENILIN SPE-4
P04385	Histamine H1 receptor mediated signaling pathway	P04485	H1	HUMAN|HGNC=5182|UniProtKB=P35367	Histamine H1 receptor	ISS	2670975	PubMed	PTHR43914:SF2	HISTAMINE H1 RECEPTOR
P04393	Ras Pathway	P04557	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	IDA	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00048	PI3 kinase pathway	P01192	p110	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02778	Sulfate assimilation	P03167	Sulfate adenylyltransferase	AQUAE|EnsemblGenome=aq_1081|UniProtKB=O67174	Probable bifunctional SAT/APS kinase	ISS			PTHR42700:SF1	SULFATE ADENYLYLTRANSFERASE
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=1953|UniProtKB=P08173	Muscarinic acetylcholine receptor M4	IDA	8100450	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00053	T cell activation	P01330	IKK	BOVIN|Ensembl=ENSBTAG00000007599|UniProtKB=Q95KV0	Inhibitor of nuclear factor kappa-B kinase subunit beta	IGI	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00021	FGF signaling pathway	P00623	FGF	MACMU|Ensembl=ENSMMUG00000002875|UniProtKB=F7HFS0	Fibroblast growth factor	ISS			PTHR11486:SF18	FIBROBLAST GROWTH FACTOR 14
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MONDO|Ensembl=ENSMODG00000004799|UniProtKB=F6VM87	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00948	Rho	CHICK|Ensembl=ENSGALG00000016485|UniProtKB=O93468	GTP-binding protein	ISS	11973360	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00019	Endothelin signaling pathway	P00570	PKA	LEIMA|EnsemblGenome=LmjF.35.3960|UniProtKB=E9AFM1	Protein kinase A catalytic subunit isoform 2	ISS	10553940	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01162	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00018	EGF receptor signaling pathway	P00549	EGF	HUMAN|HGNC=7998|UniProtKB=O14511	Pro-neuregulin-2, membrane-bound isoform	RCA			PTHR11100:SF20	PRO-NEUREGULIN-2, MEMBRANE-BOUND ISOFORM-RELATED
P05918	p38 MAPK pathway	P06026	MEKK4	BOVIN|Ensembl=ENSBTAG00000020079|UniProtKB=F1N3T0	Uncharacterized protein	ISS	12052864	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00053	T cell activation	P01311	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	BOVIN|Gene=ADRB1|UniProtKB=Q9TT96	Beta-1 adrenergic receptor	IDA	12730078	PubMed	PTHR24248:SF54	BETA-1 ADRENERGIC RECEPTOR
P00018	EGF receptor signaling pathway	P00547	PP2A	CAEEL|WormBase=WBGene00007554|UniProtKB=A9UJN4	Protein Phosphatase 2A (Two A) Regulatory subunit	ISS	10092233	PubMed	PTHR10257:SF3	PP2A-B', ISOFORM B
P00001	Adrenaline and noradrenaline biosynthesis	P00068	amine translocator	DANRE|ZFIN=ZDB-GENE-030131-4755|UniProtKB=Q6PBA3	Transporter	ISS	12719981	PubMed	PTHR11616:SF125	SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER B 0 AT1
P00015	Circadian clock system	P00505	Cry	MACMU|Ensembl=ENSMMUG00000002453|UniProtKB=F7HH05	Cryptochrome-2	ISS	10428031	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	ARATH|TAIR=AT5G61210|UniProtKB=Q9S7P9	SNAP25 homologous protein SNAP33	IC			PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00010	B cell activation	P00391	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	PANTR|Ensembl=ENSPTRG00000001389|UniProtKB=H2Q056	Uncharacterized protein	ISS	22213672	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P00048	PI3 kinase pathway	P01179	PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00046	Oxidative stress response	P01135	p38	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	8920915	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04547	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	SCHMA|EnsemblGenome=Smp_046600|UniProtKB=G4VLW2	Putative actin-1	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00021	FGF signaling pathway	P00644	p38	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	IGI	8925912	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	RAT|RGD=69651|UniProtKB=P38438	TGF-beta receptor type-2	TAS	9395284	PubMed	PTHR23255:SF55	TGF-BETA RECEPTOR TYPE-2
P00057	Wnt signaling pathway	P01440	Cadherin	DROME|FlyBase=FBgn0024836|UniProtKB=Q9V5N8	Protocadherin-like wing polarity protein stan	ISS	8120095	PubMed	PTHR24026:SF51	PROTOCADHERIN-LIKE WING POLARITY PROTEIN STAN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	IC	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00056	VEGF signaling pathway	P01417	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	DROME|FlyBase=FBgn0019947|UniProtKB=O02194	Presenilin homolog	IDA	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	TAS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00021	FGF signaling pathway	P00625	MKK3,6	MOUSE|MGI=MGI=1346868|UniProtKB=O09110	Dual specificity mitogen-activated protein kinase kinase 3	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01456	beta-arrestin	MACMU|Ensembl=ENSMMUG00000023359|UniProtKB=F7E8B5	Uncharacterized protein	ISS	11742073	PubMed	PTHR11792:SF15	S-ARRESTIN
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	ARATH|TAIR=AT5G58700|UniProtKB=Q944C1	Phosphoinositide phospholipase C 4	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00018	EGF receptor signaling pathway	P00562	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	12810719	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00045	Notch signaling pathway	P01103	Next	MONDO|Ensembl=ENSMODG00000004910|UniProtKB=F7C1Q4	Delta-like protein	ISS	8955070	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00036	Interleukin signaling pathway	P00983	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IC	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00591	PLCbeta	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IGI	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	DROME|FlyBase=FBgn0010333|UniProtKB=P40792	Ras-related protein Rac1	ISS			PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00036	Interleukin signaling pathway	P00962	ELK	BOVIN|Ensembl=ENSBTAG00000001509|UniProtKB=A2VDT5	ELK3, ETS-domain protein (SRF accessory protein 2)	ISS			PTHR11849:SF172	ETS DOMAIN-CONTAINING PROTEIN ELK-3
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	CHLTR|EnsemblGenome=CT_816|UniProtKB=O84823	Glutamine--fructose-6-phosphate aminotransferase [isomerizing]	ISS			PTHR10937:SF0	GH12731P-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05913	Enkephalin release	P05974	G-Protein (i)	TAKRU|Ensembl=ENSTRUG00000016101|UniProtKB=H2UW32	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	PYRAE|EnsemblGenome=PAE2164|UniProtKB=Q8ZVR0	TATA-box-binding protein	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00729	Goalpha	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	IDA	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	DROME|FlyBase=FBgn0026379|UniProtKB=Q7KMQ6	IP16020p	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000006999|UniProtKB=E1BDQ4	Uncharacterized protein	ISS	15226293	PubMed	PTHR13715:SF15	RYANODINE RECEPTOR 1
P05918	p38 MAPK pathway	P06015	p38gamma	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000002647|UniProtKB=F7DIB7	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	HUMAN|HGNC=4584|UniProtKB=Q05586	Glutamate receptor ionotropic, NMDA 1	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	G01546	Cyclin d	HUMAN|HGNC=1582|UniProtKB=P24385	G1/S-specific cyclin-D1	ISS	12356903	PubMed	PTHR10177:SF67	G1/S-SPECIFIC CYCLIN-D1
P00048	PI3 kinase pathway	P01188	Gbetagamma	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00018	EGF receptor signaling pathway	P00550	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	10521483	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CANLF|Ensembl=ENSCAFG00000002617|UniProtKB=E2QUL1	Uncharacterized protein	ISS	11554554	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00029	Huntington disease	P00807	Actin	PLAF7|EnsemblGenome=PF14_0124|UniProtKB=Q8ILW9	Actin-2	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00011	Blood coagulation	P00408	Plasminogen	RAT|RGD=619893|UniProtKB=Q01177	Plasminogen	ISS	15928602	gi	PTHR24261:SF5	PLASMINOGEN
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00005	Angiogenesis	P00189	Fzd	MACMU|Ensembl=ENSMMUG00000013656|UniProtKB=F7GI70	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF126	FRIZZLED-5
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	G01548	I-SMAD	BOVIN|Ensembl=ENSBTAG00000012441|UniProtKB=E1B8T7	Mothers against decapentaplegic homolog	ISS	9335505	PubMed	PTHR13703:SF27	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 7
P06216	SCW signaling pathway	P06324	PDP	DROME|FlyBase=FBgn0029958|UniProtKB=Q9W3Q1	GM14286p	IDA	16510868	PubMed	PTHR13832:SF503	PYRUVATE DEHYDROGENASE  ACETYL-TRANSFERRING  -PHOSPHATASE 1, MITOCHONDRIAL
P00046	Oxidative stress response	P01135	p38	CAEEL|WormBase=WBGene00004055|UniProtKB=Q17446	Mitogen-activated protein kinase pmk-1	TAS	11274345	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00021	FGF signaling pathway	P00640	PI3K	ANOGA|Gene=AgaP_AGAP010273|UniProtKB=Q7PMF0	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00060	Ubiquitin proteasome pathway	P01490	E3	PANTR|Ensembl=ENSPTRG00000006829|UniProtKB=H2Q918	Ubiquitin protein ligase E3A	ISS			PTHR11254:SF301	UBIQUITIN-PROTEIN LIGASE E3A
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	RAT|RGD=621516|UniProtKB=G3V6P8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	SCHMA|EnsemblGenome=Smp_000740|UniProtKB=Q547D2	Multiubiquitin binding protein S5a	ISS	3914476	gi	PTHR10223:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4
P04378	Beta2 adrenergic receptor signaling pathway	P04440	Beta2	BOVIN|Ensembl=ENSBTAG00000002144|UniProtKB=Q28044	Beta-2 adrenergic receptor	ISS	12063255	PubMed	PTHR24248:SF21	BETA-2 ADRENERGIC RECEPTOR
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00056	VEGF signaling pathway	P01419	Ets	MONDO|Ensembl=ENSMODG00000004730|UniProtKB=F6Y1Z2	Uncharacterized protein	ISS	15579511	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	IC	8838325	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00019	Endothelin signaling pathway	P00586	Gq	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00005	Angiogenesis	P00224	PDGF	BOVIN|Ensembl=ENSBTAG00000021697|UniProtKB=B1H0W5	PDGFB protein	ISS			PTHR11633:SF2	PLATELET-DERIVED GROWTH FACTOR SUBUNIT B
P00034	Integrin signalling pathway	P00932	FAK	HUMAN|HGNC=9612|UniProtKB=Q14289	Protein-tyrosine kinase 2-beta	IPI	12640026	PubMed	PTHR24418:SF94	PROTEIN-TYROSINE KINASE 2-BETA
P04398	p53 pathway feedback loops 2	G04714	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04398	p53 pathway feedback loops 2	P04661	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P02746	Heme biosynthesis	P02976	Protoporphyrinogen oxidase	LEPIN|EnsemblGenome=LA_4200|UniProtKB=Q8EYL3	L-amino acid oxidase	ISS			PTHR42923:SF3	PROTOPORPHYRINOGEN OXIDASE
P00021	FGF signaling pathway	P00627	ERK1-2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	RAT|RGD=71017|UniProtKB=Q9QZH0	Frizzled-4	TAS	8717036	PubMed	PTHR11309:SF23	FRIZZLED-4
P04398	p53 pathway feedback loops 2	P04649	Myc	DANRE|ZFIN=ZDB-GENE-990415-162|UniProtKB=P52160	Transcriptional regulator Myc-A	TAS	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00702	CPB	MOUSE|MGI=MGI=2384786|UniProtKB=Q91XE9	Cyclic AMP-responsive element-binding protein 3-like protein 3	ISS			PTHR22952:SF98	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 3
P05915	Opioid proenkephalin pathway	P05994	G-protein	BOVIN|Ensembl=ENSBTAG00000003043|UniProtKB=P63212	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	MOUSE|MGI=MGI=894315|UniProtKB=Q99JI6	Ras-related protein Rap-1b	ISS	8576107	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00379	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00005	Angiogenesis	P00203	Erk	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00916	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IPI	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=2685045|UniProtKB=E9QAN8	Protein Pik3c2b	IPI	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00029	Huntington disease	P00774	Dynein complex	MOUSE|MGI=MGI=103147|UniProtKB=Q9JHU4	Cytoplasmic dynein 1 heavy chain 1	IPI	9454836	PubMed	PTHR10676:SF314	CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1
P00006	Apoptosis signaling pathway	P00317	Fos	BOVIN|Ensembl=ENSBTAG00000004322|UniProtKB=O77628	Proto-oncogene c-Fos	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	IDA	20451058	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00014	Cholesterol biosynthesis	P00490	Dimethylallyl trans-transferase	RAT|RGD=1359680|UniProtKB=Q6F596	Geranylgeranyl pyrophosphate synthase	RCA			PTHR12001:SF44	GERANYLGERANYL PYROPHOSPHATE SYNTHASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	ISS			PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00015	Circadian clock system	G01503	per	MACMU|Ensembl=ENSMMUG00000018930|UniProtKB=F6YLJ6	Uncharacterized protein	ISS	11232563	PubMed	PTHR11269:SF9	PERIOD CIRCADIAN PROTEIN HOMOLOG 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	TAS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	PANTR|Ensembl=ENSPTRG00000016412|UniProtKB=H2R9Y7	Uncharacterized protein	ISS	11055438	PubMed	PTHR10117:SF8	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 3
P00051	TCA cycle	P01266	Pyruvate Dehydrogenase	MOUSE|MGI=MGI=1343087|UniProtKB=Q9JK42	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	ISS			PTHR11947:SF15	PYRUVATE DEHYDROGENASE  ACETYL-TRANSFERRING   KINASE ISOZYME 2, MITOCHONDRIAL
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00317	Fos	BOVIN|Ensembl=ENSBTAG00000004322|UniProtKB=O77628	Proto-oncogene c-Fos	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04398	p53 pathway feedback loops 2	P04665	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00321	HSP70	ORYSJ|EnsemblGenome=OS11G0703900|UniProtKB=Q53NM9	DnaK-type molecular chaperone hsp70-rice	ISS	12150907	PubMed	PTHR19375:SF325	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 37E-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	188830	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00875	GEF	BOVIN|Ensembl=ENSBTAG00000015609|UniProtKB=F1N1Q7	Uncharacterized protein	ISS	11955434	PubMed	PTHR22829:SF6	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE-DEPENDENT RAC EXCHANGER 1 PROTEIN
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	HUMAN|HGNC=4579|UniProtKB=P39086	Glutamate receptor ionotropic, kainate 1	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00034	Integrin signalling pathway	P00925	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IDA	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00019	Endothelin signaling pathway	P00591	PLCbeta	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IGI	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	8170357	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00941	Integrin alpha	HUMAN|HGNC=6136|UniProtKB=Q9UKX5	Integrin alpha-11	IPI	3487386	PubMed	PTHR23220:SF21	INTEGRIN ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PRIPA|Gene=PPA17339|UniProtKB=H3F5B4	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF352	ACTIN
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00464	Fyn	MONDO|Ensembl=ENSMODG00000017905|UniProtKB=F7FG65	Tyrosine-protein kinase	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P02736	Coenzyme A biosynthesis	P02884	Dephospho-CoA kinase	MOUSE|MGI=MGI=1915337|UniProtKB=Q8BHC4	Dephospho-CoA kinase domain-containing protein	ISS			PTHR10695:SF35	DEPHOSPHO-COA KINASE DOMAIN-CONTAINING PROTEIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	ISS	11707292	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00019	Endothelin signaling pathway	P00582	COX-2	MOUSE|MGI=MGI=97798|UniProtKB=Q05769	Prostaglandin G/H synthase 2	IPI	97122334	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P05731	GABA-B receptor II signaling	P05752	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00038	JAK/STAT signaling pathway	P01027	STAT	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	RAT|RGD=621789|UniProtKB=P70539	Activin receptor type-1C	TAS	9395284	PubMed	PTHR23255:SF58	ACTIVIN RECEPTOR TYPE-1C
P00029	Huntington disease	P00807	Actin	DROME|FlyBase=FBgn0000044|UniProtKB=P53501	Actin-57B	IDA	14684598	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00006	Apoptosis signaling pathway	P00310	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IDA	129387	gi	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00037	Ionotropic glutamate receptor pathway	P01026	KA	HUMAN|HGNC=4583|UniProtKB=Q16478	Glutamate receptor ionotropic, kainate 5	ISS	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00016	Cytoskeletal regulation by Rho GTPase	P00513	Op18/stathmin	MACMU|Ensembl=ENSMMUG00000018670|UniProtKB=F6ZYT6	Uncharacterized protein	ISS			PTHR10104:SF6	STATHMIN-4
P00012	Cadherin signaling pathway	P00474	Wnt	BOVIN|Ensembl=ENSBTAG00000014291|UniProtKB=A6H6X8	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CAEEL|WormBase=WBGene00004037|UniProtKB=Q9XWB7	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF9	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	TAKRU|Ensembl=ENSTRUG00000011169|UniProtKB=H2TU36	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000000931|UniProtKB=H2PZC4	Protein kinase N2	ISS	11554554	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00005	Angiogenesis	P00254	GTPase	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	ISS	12169092	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008018|UniProtKB=F7EPG4	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P06587	Nicotine pharmacodynamics pathway	P06590	GNG	BOVIN|Ensembl=ENSBTAG00000003043|UniProtKB=P63212	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00017	DNA replication	P00527	Histones	MACMU|Ensembl=ENSMMUG00000021766|UniProtKB=F6QR30	Histone H3	ISS	12413958	PubMed	PTHR11426:SF179	HISTONE H3.3
P00054	Toll receptor signaling pathway	P01368	MKK2	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P02770	Pyridoxal phosphate salvage pathway	P03120	Pyridoxamine-5-phosphate oxidase	HUMAN|HGNC=30260|UniProtKB=Q9NVS9	Pyridoxine-5'-phosphate oxidase	ISS	14697241	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	CAEEL|WormBase=WBGene00006797|UniProtKB=Q9N587	Acetylcholine receptor subunit alpha-type unc-63	IC	85270494	PubMed	PTHR18945:SF592	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-LIKE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05925	beta-ARR1	RAT|RGD=2156|UniProtKB=P29066	Beta-arrestin-1	RCA	11742073	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00048	PI3 kinase pathway	P01199	Galpha	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	IDA	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00220	c-Jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	3136397	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	DICDI|dictyBase=DDB_G0277825|UniProtKB=O96622	Actin-related protein 2/3 complex subunit 1	ISS	12932731	PubMed	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P00056	VEGF signaling pathway	P01425	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	11554554	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04570	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IDA	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01444	Wnt	BOVIN|Ensembl=ENSBTAG00000020267|UniProtKB=F1MKX1	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00514	MLCK	PANTR|Ensembl=ENSPTRG00000013361|UniProtKB=H2QK55	Uncharacterized protein	ISS	11157482	PubMed	PTHR45210:SF1	MYOSIN LIGHT CHAIN KINASE 2, SKELETAL/CARDIAC MUSCLE
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00047	PDGF signaling pathway	P01171	PLCgamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00056	VEGF signaling pathway	P01422	eNOS	HUMAN|HGNC=7876|UniProtKB=P29474	Nitric oxide synthase, endothelial	IEP	9837777	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00023	General transcription regulation	P00660	RNA Polymerase II	ARATH|TAIR=AT2G41340|UniProtKB=Q9ZVB9	DNA-directed RNA polymerases IV and V subunit 5B	ISS	11313498	gi	PTHR10535:SF2	DNA-DIRECTED RNA POLYMERASE V SUBUNIT 5A-RELATED
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	RAT|RGD=2746|UniProtKB=P31424	Metabotropic glutamate receptor 5	ISS	14614461	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00037	Ionotropic glutamate receptor pathway	P01026	KA	CHICK|Ensembl=ENSGALG00000006638|UniProtKB=R4GGL9	Uncharacterized protein	ISS	1648176	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00748	Gbeta5L	CANLF|Ensembl=ENSCAFG00000015662|UniProtKB=E2RHY4	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00025	Hedgehog signaling pathway	P00685	Smoothened	BOVIN|Ensembl=ENSBTAG00000013287|UniProtKB=E1BE57	Uncharacterized protein	ISS	10021362	PubMed	PTHR11309:SF35	SMOOTHENED HOMOLOG
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MONDO|Ensembl=ENSMODG00000004799|UniProtKB=F6VM87	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00038	JAK/STAT signaling pathway	P01027	STAT	CHICK|Ensembl=ENSGALG00000003267|UniProtKB=Q6DV79	Signal transducer and activator of transcription 3	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00048	PI3 kinase pathway	P01185	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04555	PDK	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00020	FAS signaling pathway	P00593	Caspase9	HUMAN|HGNC=1511|UniProtKB=P55211	Caspase-9	IGI	11440972	PubMed	PTHR10454:SF157	CASPASE-9
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	ARATH|TAIR=AT1G79000|UniProtKB=Q9C5X9	Histone acetyltransferase HAC1	TAS	10664585	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00006	Apoptosis signaling pathway	P00296	DAXX	PANTR|Ensembl=ENSPTRG00000018045|UniProtKB=H2QST5	Uncharacterized protein	ISS	9215629	PubMed	PTHR12766:SF7	DEATH DOMAIN-ASSOCIATED PROTEIN 6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	CANLF|Ensembl=ENSCAFG00000024151|UniProtKB=E2R795	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	TAS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00008	Axon guidance mediated by Slit/Robo	P00342	Slit	DANRE|ZFIN=ZDB-GENE-010306-3|UniProtKB=F1QQE4	Uncharacterized protein	ISS			PTHR24373:SF107	SLIT HOMOLOG 2 PROTEIN
P00054	Toll receptor signaling pathway	P01352	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00012	Cadherin signaling pathway	P00470	F-actin	CAEEL|WormBase=WBGene00000065|UniProtKB=P0DM42	Actin-3	IC	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00059	p53 pathway	P01483	Mdm2	PANTR|Ensembl=ENSPTRG00000001889|UniProtKB=H2R875	Mdm4 p53 binding protein homolog	ISS			PTHR13844:SF20	PROTEIN MDM4
P00021	FGF signaling pathway	P00638	PLCgamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00936	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00030	Hypoxia response via HIF activation	P00823	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	DANRE|ZFIN=ZDB-GENE-980526-352|UniProtKB=P47793	Protein Wnt-4a	TAS	11266476	PubMed	PTHR12027:SF103	PROTEIN WNT-4A
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	IDA	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00006	Apoptosis signaling pathway	P00269	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00797	p53	HUMAN|HGNC=11998|UniProtKB=P04637	Cellular tumor antigen p53	TAS	11313951	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P06664	Gonadotropin-releasing hormone receptor pathway	P06786	ERK1/2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	RCA	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00807	Actin	DANRE|ZFIN=ZDB-GENE-030131-55|UniProtKB=Q6XNL8	Actin	IDA	14684598	PubMed	PTHR11937:SF263	ACTIN
P00011	Blood coagulation	P00429	PN2	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	ISS	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	STRPU|EnsemblGenome=SPU_025182|UniProtKB=W4ZAK5	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MOUSE|MGI=MGI=109320|UniProtKB=O54732	Matrix metalloproteinase-15	TAS	12834808	PubMed	PTHR10201:SF25	MATRIX METALLOPROTEINASE-15
P02779	Thiamin biosynthesis	P03173	Thiamin phosphate synthase	BACTN|EnsemblGenome=BT_0652|UniProtKB=Q8AA13	Thiamine-phosphate synthase	ISS			PTHR20857:SF15	THIAMINE BIOSYNTHETIC BIFUNCTIONAL ENZYME
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00047	PDGF signaling pathway	P01164	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00006	Apoptosis signaling pathway	P00299	Caspase 8	PANTR|Ensembl=ENSPTRG00000012801|UniProtKB=H2QJ86	Caspase 8, apoptosis-related cysteine peptidase	ISS	11788820	PubMed	PTHR10454:SF162	CASPASE-8
P00018	EGF receptor signaling pathway	P00551	Akt	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	ISS	14526383	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P02785	Valine biosynthesis	P03217	Dihydroxy isovalerate reductoisomerase	METAC|EnsemblGenome=MA_3790|UniProtKB=Q8TJJ4	Ketol-acid reductoisomerase	ISS			PTHR21371:SF1	KETOL-ACID REDUCTOISOMERASE, CHLOROPLASTIC
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-478663|UniProtKB=F7EG64	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P02756	N-acetylglucosamine metabolism	P03036	N-acetylglucosamine-6-phosphate deacetylase	MACMU|Ensembl=ENSMMUG00000019095|UniProtKB=F6TFT9	Uncharacterized protein	ISS			PTHR11113:SF14	N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE
P00005	Angiogenesis	P00253	Axin	MACMU|Ensembl=ENSMMUG00000000605|UniProtKB=F6Y8V8	Uncharacterized protein	ISS	12356903	PubMed	PTHR10845:SF11	AXIN-1
P00049	Parkinson disease	P01211	ERK	PANTR|Ensembl=ENSPTRG00000008867|UniProtKB=H2QCF3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	ARATH|TAIR=AT2G19470|UniProtKB=Q9ZUP4	At2g19470	IDA	10617630	PubMed	PTHR11909:SF298	CASEIN KINASE 1-LIKE PROTEIN 12-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04456	ProCRF (Pro Corticotropin-Releasing Factor)	XENTR|Ensembl=ENSXETG00000030233|UniProtKB=F6XHX7	Uncharacterized protein	ISS	122560	OMIM	PTHR15035:SF9	CORTICOLIBERIN
P05913	Enkephalin release	P05972	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00018	EGF receptor signaling pathway	P00562	p38	DROME|FlyBase=FBgn0024846|UniProtKB=O61443	Mitogen-activated protein kinase 14B	ISS	11274345	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00019	Endothelin signaling pathway	P00570	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00936	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IPI	1171954	gi	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00776	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P02787	Vitamin B6 metabolism	P03236	Pyridoxamine phosphate oxidase	PANTR|Ensembl=ENSPTRG00000009343|UniProtKB=H2QDB2	Pyridoxamine 5'-phosphate oxidase	ISS	14697241	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00048	PI3 kinase pathway	P01192	p110	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	11591316	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	XENTR|Xenbase=XB-GENE-1010483|UniProtKB=F7AF72	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	MOUSE|MGI=MGI=95814|UniProtKB=Q60934	Glutamate receptor ionotropic, kainate 1	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P05916	Opioid prodynorphin pathway	P06002	G-protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04392	P53 pathway feedback loops 1	G04682	MDM-2	RAT|RGD=1305332|UniProtKB=A0A0G2JVC1	Protein Mdm2	ISS	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00009	Axon guidance mediated by netrin	P00366	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P06959	CCKR signaling map	P07077	CCK	HUMAN|HGNC=1569|UniProtKB=P06307	Cholecystokinin	RCA	9169450	PubMed	PTHR10786:SF0	CHOLECYSTOKININ
P00029	Huntington disease	P00780	Microtubule	PHYPA|Gene=PHYPADRAFT_213086|UniProtKB=A9SJR1	Beta-tubulin 4	ISS	9454836	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04397	p53 pathway by glucose deprivation	P04641	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00021	FGF signaling pathway	P00627	ERK1-2	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04397	p53 pathway by glucose deprivation	P04636	S6K	ORNAN|Ensembl=ENSOANG00000002226|UniProtKB=F6TPX7	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IC	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00011	Blood coagulation	P00433	uPAR	HUMAN|HGNC=9053|UniProtKB=Q03405	Urokinase plasminogen activator surface receptor	ISS	13641309	gi	PTHR10624:SF6	UROKINASE PLASMINOGEN ACTIVATOR SURFACE RECEPTOR
P00005	Angiogenesis	P00186	FGFR-1	HUMAN|HGNC=3688|UniProtKB=P11362	Fibroblast growth factor receptor 1	IDA	12799194	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00019	Endothelin signaling pathway	P00584	Gs	HUMAN|HGNC=4388|UniProtKB=P38405	Guanine nucleotide-binding protein G(olf) subunit alpha	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00561	STAT	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	14984365	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=94925|UniProtKB=P30728	D(3) dopamine receptor	IDA	1319557	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	ANOGA|EnsemblGenome=AGAP001478|UniProtKB=Q7PXM3	AGAP001478-PA	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	IDA	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06847	JNK1/2	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	RCA	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00199	JNKK1	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00047	PDGF signaling pathway	P01173	STAT	HUMAN|HGNC=11367|UniProtKB=P51692	Signal transducer and activator of transcription 5B	ISS	96210005	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00539	14-3-3	ORNAN|Ensembl=ENSOANG00000003572|UniProtKB=F7DGH9	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00010	B cell activation	P00370	NFkappaB	CHICK|Ensembl=ENSGALG00000012304|UniProtKB=Q04861	Nuclear factor NF-kappa-B p105 subunit	IDA	12574369	PubMed	PTHR24169:SF9	NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04392	P53 pathway feedback loops 1	P04536	Mdm2	PANTR|Ensembl=ENSPTRG00000005203|UniProtKB=H2R792	Mdm2 p53 binding protein homolog	ISS	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00012	Cadherin signaling pathway	P00470	F-actin	ORNAN|Ensembl=ENSOANG00000007581|UniProtKB=F6QWB7	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P04393	Ras Pathway	P04567	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IDA	129387	gi	PTHR10048:SF14	PI-3 KINASE
P04395	Vasopressin synthesis	P04596	Endo Peptidase	BOVIN|Gene=PREP|UniProtKB=Q9XTA2	Prolyl endopeptidase	IC	9695945	PubMed	PTHR42881:SF2	PROLYL ENDOPEPTIDASE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	XENTR|Xenbase=XB-GENE-494200|UniProtKB=F7CS79	Uncharacterized protein	ISS	11554554	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	HUMAN|HGNC=8927|UniProtKB=Q93100	Phosphorylase b kinase regulatory subunit beta	IDA	10487978	PubMed	PTHR10749:SF8	PHOSPHORYLASE B KINASE REGULATORY SUBUNIT BETA
P00059	p53 pathway	P04633	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02749	Leucine biosynthesis	P02999	2-Isopropylmalate synthase	METAC|EnsemblGenome=MA_4264|UniProtKB=Q8TI92	Isopropylmalate/homocitrate/citramalate synthase family protein	ISS			PTHR42880:SF1	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00638	PLCgamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00019	Endothelin signaling pathway	P00591	PLCbeta	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00236	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01281	SARA	DROME|FlyBase=FBgn0026369|UniProtKB=Q7K9H6	FI05490p	TAS	http://flybase.org/reports/FBgn0026369.html	Website	PTHR22835:SF299	FI05490P
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	XENTR|Xenbase=XB-GENE-6052814|UniProtKB=Q6P1T1	Uncharacterized protein	ISS	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00010	B cell activation	P00397	IKK	PANTR|Ensembl=ENSPTRG00000020202|UniProtKB=H2QW34	Uncharacterized protein	ISS	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00045	Notch signaling pathway	P01110	Presenilin	RAT|RGD=3425|UniProtKB=P97887	Presenilin-1	IEP	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	BRAFL|Gene=BRAFLDRAFT_123893|UniProtKB=C3XQF4	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00322	Cytochrome C	PANTR|Ensembl=ENSPTRG00000018996|UniProtKB=P99998	Cytochrome c	ISS			PTHR11961:SF15	CYTOCHROME C
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CAEEL|WormBase=WBGene00001187|UniProtKB=Q8MQA1	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00006	Apoptosis signaling pathway	P00318	PKCs	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IDA	10644715	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Gene=SSTR2|UniProtKB=P34993	Somatostatin receptor type 2	ISS	12562507	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P00019	Endothelin signaling pathway	P00589	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IGI	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000002349|UniProtKB=P61267	Syntaxin-1B	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IDA	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00049	Parkinson disease	P01219	SAPK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	TAS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01465	Ggamma	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00029	Huntington disease	P00780	Microtubule	BOVIN|Gene=TUBB6|UniProtKB=Q2HJ81	Tubulin beta-6 chain	ISS	9454836	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00034	Integrin signalling pathway	P00907	ERK	MONDO|Ensembl=ENSMODG00000001962|UniProtKB=F6V2H6	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00046	Oxidative stress response	P01129	JNK1/2	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MACMU|Ensembl=ENSMMUG00000031972|UniProtKB=F7GWC3	Actin-related protein 2/3 complex subunit 4	ISS	9230079	PubMed	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	HUMAN|HGNC=4583|UniProtKB=Q16478	Glutamate receptor ionotropic, kainate 5	ISS	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00034	Integrin signalling pathway	P00948	Rho	HUMAN|HGNC=667|UniProtKB=P61586	Transforming protein RhoA	ISS	12039949	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000010266|UniProtKB=F6PV18	Uncharacterized protein	ISS	14500986	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00005	Angiogenesis	P00252	Grb2	CAEBR|Gene=CBG16856|UniProtKB=A8XPY6	Protein CBR-SEM-5	ISS			PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	BOVIN|Ensembl=ENSBTAG00000021837|UniProtKB=Q08DC7	Regulator of G-protein signaling 19	ISS	8756726	PubMed	PTHR10845:SF145	REGULATOR OF G-PROTEIN SIGNALING 19
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	ARATH|TAIR=AT5G15570|UniProtKB=Q9LF25	Bromodomain transcription factor	ISS	604905	OMIM	PTHR12321:SF53	BROMODOMAIN TRANSCRIPTION FACTOR
P00005	Angiogenesis	P00181	SHP2	MONDO|Ensembl=ENSMODG00000018156|UniProtKB=F7CWQ1	Tyrosine-protein phosphatase non-receptor type	ISS			PTHR19134:SF65	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 6
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P05915	Opioid proenkephalin pathway	P05994	G-protein	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000018989|UniProtKB=A5D7D8	GRM3 protein	ISS	12488551	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	ORYSJ|EnsemblGenome=OS01G0874900|UniProtKB=Q8RYY6	Os01g0874900 protein	ISS			PTHR11680:SF7	SERINE HYDROXYMETHYLTRANSFERASE 6-RELATED
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00047	PDGF signaling pathway	P01161	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00034	Integrin signalling pathway	P00916	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00049	Parkinson disease	P01208	Hsp70	TRIVA|Gene=TVAG_184320|UniProtKB=A2E9W8	Cytosolic heat shock protein 70, putative	IDA	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00030	Hypoxia response via HIF activation	P00818	HIF-1alpha	BOVIN|Gene=HIF1A|UniProtKB=Q9XTA5	Hypoxia-inducible factor 1-alpha	TAS	9606183	PubMed	PTHR23043:SF7	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00053	T cell activation	P01332	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00062	TH	MACMU|Ensembl=ENSMMUG00000003912|UniProtKB=F6ZV38	Uncharacterized protein	ISS	12480184	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04396	Vitamin D metabolism and pathway	P04603	1alpha-Hydroxylase	MOUSE|MGI=MGI=1098274|UniProtKB=O35084	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	IDA	11013342	PubMed	PTHR24291:SF3	25-HYDROXYVITAMIN D-1 ALPHA HYDROXYLASE, MITOCHONDRIAL
P00018	EGF receptor signaling pathway	P00562	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	IPI	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00780	Microtubule	SCHMA|EnsemblGenome=Smp_030730|UniProtKB=G4LW34	Tubulin beta chain,putative	ISS	9454836	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MONDO|Ensembl=ENSMODG00000020977|UniProtKB=F6S5B1	Uncharacterized protein (Fragment)	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00059	p53 pathway	P01480	PTEN	TAKRU|Ensembl=ENSTRUG00000009851|UniProtKB=H2TJ90	Uncharacterized protein	IGI	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00034	Integrin signalling pathway	P00922	Collagen	MOUSE|MGI=MGI=88458|UniProtKB=Q3U962	Collagen alpha-2(V) chain	IDA	10778855	PubMed	PTHR24023:SF539	COLLAGEN ALPHA-2 V  CHAIN
P00021	FGF signaling pathway	P00632	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	2837282	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00036	Interleukin signaling pathway	P00987	SRF	HUMAN|HGNC=11291|UniProtKB=P11831	Serum response factor	TAS	15326221	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DAPPU|EnsemblGenome=DAPPUDRAFT_59367|UniProtKB=E9H7Z0	Guanine nucleotide-binding protein G(O) subunit alpha 1	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00047	PDGF signaling pathway	P01165	SRF	BOVIN|Ensembl=ENSBTAG00000012777|UniProtKB=E1BJP4	Uncharacterized protein	ISS	15170389	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00036	Interleukin signaling pathway	P00965	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IC	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01236	Casein kinase II	MONDO|Ensembl=ENSMODG00000015287|UniProtKB=F6T6M8	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MONDO|Ensembl=ENSMODG00000023470|UniProtKB=F6T6U1	Uncharacterized protein	ISS			PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P02738	De novo purine biosynthesis	P02904	Guanylate kinase	ANOGA|EnsemblGenome=AGAP011105|UniProtKB=Q7PSP6	AGAP011105-PA	ISS			PTHR23117:SF13	GUANYLATE KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04393	Ras Pathway	P04579	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	10982827	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00034	Integrin signalling pathway	P00907	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05913	Enkephalin release	P05974	G-Protein (i)	ORNAN|Ensembl=ENSOANG00000013961|UniProtKB=F6VPY1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P04398	p53 pathway feedback loops 2	P04658	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	DANRE|ZFIN=ZDB-GENE-051202-1|UniProtKB=E7F101	Uncharacterized protein	ISS	92049750	PubMed	PTHR44391:SF2	SUBFAMILY NOT NAMED
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	XENTR|GeneID=394982|UniProtKB=P20399	Actin, alpha cardiac muscle 2	ISS	11889126	PubMed	PTHR11937:SF263	ACTIN
P00012	Cadherin signaling pathway	P00475	Frizzled	MONDO|Ensembl=ENSMODG00000010505|UniProtKB=F7E9U1	Uncharacterized protein (Fragment)	ISS	8717036	PubMed	PTHR11309:SF81	FRIZZLED-1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02927	Dihydrooratate oxidase	FUSNN|EnsemblGenome=FN0424|UniProtKB=Q8RG85	Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit	ISS			PTHR43843:SF1	DIHYDROOROTATE DEHYDROGENASE  FUMARATE
P06959	CCKR signaling map	P07133	ITGAV	HUMAN|HGNC=6150|UniProtKB=P06756	Integrin alpha-V	RCA	22110279	PubMed	PTHR23220:SF4	INTEGRIN ALPHA-V
P00010	B cell activation	P00402	Jnk	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04395	Vasopressin synthesis	P04596	Endo Peptidase	MOUSE|MGI=MGI=2441932|UniProtKB=Q8C167	Prolyl endopeptidase-like	IC	9695945	PubMed	PTHR11757:SF12	PROLYL ENDOPEPTIDASE-LIKE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	YEAST|SGD=S000000028|UniProtKB=P31109	Synaptobrevin homolog 1	ISS			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=12783|UniProtKB=P56705	Protein Wnt-4	IDA	8717036	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00924	Raf	MOUSE|MGI=MGI=88190|UniProtKB=P28028	Serine/threonine-protein kinase B-raf	IPI	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	TAS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00012	Cadherin signaling pathway	P00471	Cadherin	ORNAN|Ensembl=ENSOANG00000002500|UniProtKB=F6VEV5	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF96	CADHERIN-12
P00046	Oxidative stress response	P01131	MKP5	MOUSE|MGI=MGI=101911|UniProtKB=Q05922	Dual specificity protein phosphatase 2	ISS			PTHR10159:SF109	DUAL SPECIFICITY PROTEIN PHOSPHATASE 2
P04398	p53 pathway feedback loops 2	P04665	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00036	Interleukin signaling pathway	P00965	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00137	Tip60	CHICK|Ensembl=ENSGALG00000009944|UniProtKB=Q5ZK16	Histone acetyltransferase	ISS			PTHR10615:SF102	HISTONE ACETYLTRANSFERASE KAT7
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	MACMU|Ensembl=ENSMMUG00000017017|UniProtKB=F7FVL2	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P04393	Ras Pathway	P04542	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01316	MHC-antigen	PANTR|Ensembl=ENSPTRG00000018026|UniProtKB=H2QSS1	Major histocompatibility complex, class II, DM alpha	ISS	73139	PubMed	PTHR19944:SF50	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DM ALPHA CHAIN
P00010	B cell activation	P00384	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P02757	O-antigen biosynthesis	P03049	Glucosamine-1-phosphate acetyltransferase	BACSU|EnsemblGenome=BSU00500|UniProtKB=P14192	Bifunctional protein GlmU	ISS			PTHR43584:SF3	BIFUNCTIONAL PROTEIN GLMU
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00019	Endothelin signaling pathway	P00566	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01438	PP2A	MACMU|Ensembl=ENSMMUG00000013047|UniProtKB=F7H808	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00223	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	THEMA|EnsemblGenome=TM_0720|UniProtKB=Q9WZH9	Serine hydroxymethyltransferase	ISS			PTHR11680:SF21	SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00005	Angiogenesis	P00231	HSP27	RAT|RGD=2414|UniProtKB=P23928	Alpha-crystallin B chain	ISS			PTHR11527:SF37	ALPHA-CRYSTALLIN B CHAIN
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	BOVIN|Ensembl=ENSBTAG00000023730|UniProtKB=Q2T9S0	Tubulin beta-3 chain	ISS	9454836	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00036	Interleukin signaling pathway	P00979	MAPKAPK2	HUMAN|HGNC=6887|UniProtKB=P49137	MAP kinase-activated protein kinase 2	IDA	9628873	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05915	Opioid proenkephalin pathway	P05994	G-protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05916	Opioid prodynorphin pathway	P06002	G-protein	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00024	Glycolysis	P00679	Aldolase	MOUSE|MGI=MGI=2447811|UniProtKB=A6ZI46	Fructose-bisphosphate aldolase	ISS	3391172	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	ISS	8787761	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	87226391	PubMed	PTHR24070:SF385	GTPASE HRAS
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00056	VEGF signaling pathway	P01408	Akt/PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P05731	GABA-B receptor II signaling	P05755	Gbeta	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00005	Angiogenesis	P00195	APC	MOUSE|MGI=MGI=88039|UniProtKB=Q61315	Adenomatous polyposis coli protein	ISS	8259518	PubMed	PTHR12607:SF11	ADENOMATOUS POLYPOSIS COLI PROTEIN
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00091	Aph-1	BOVIN|Ensembl=ENSBTAG00000021482|UniProtKB=Q3SZ69	Anterior pharynx defective 1 homolog A (C. elegans)	ISS	12110170	PubMed	PTHR12889:SF3	GAMMA-SECRETASE SUBUNIT APH-1A
P04398	p53 pathway feedback loops 2	P04665	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00589	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	IGI	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	PANTR|Ensembl=ENSPTRG00000010617|UniProtKB=H2QFL8	Notch 3	ISS	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00057	Wnt signaling pathway	P01457	GBeta	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DROME|FlyBase=FBgn0020621|UniProtKB=A1Z7T0	Serine/threonine-protein kinase N	IC	10644715	PubMed	PTHR24356:SF210	SERINE/THREONINE-PROTEIN KINASE N
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=107469|UniProtKB=Q8K3R3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	10934033	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00054	Toll receptor signaling pathway	P01345	IKKalpha	CANLF|Ensembl=ENSCAFG00000009588|UniProtKB=E2RNA9	Uncharacterized protein	ISS	9346484	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P04393	Ras Pathway	P04546	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	IPI	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00053	T cell activation	P01336	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IGI	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DANRE|ZFIN=ZDB-GENE-030131-1229|UniProtKB=Q6DHS1	Actin, alpha 2, smooth muscle, aorta	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	DROME|FlyBase=FBgn0010215|UniProtKB=P35220	Catenin alpha	TAS	1768802	PubMed	PTHR18914:SF9	CATENIN ALPHA
P00057	Wnt signaling pathway	P01471	alpha-catenin	MACMU|Ensembl=ENSMMUG00000016902|UniProtKB=F7FBX6	Uncharacterized protein	ISS	9362521	PubMed	PTHR18914:SF21	CATENIN ALPHA-3
P00019	Endothelin signaling pathway	P00570	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01315	Calcineurin	HUMAN|HGNC=9314|UniProtKB=Q08209	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	IGI	7532676	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00384	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00049	Parkinson disease	P01242	Casein kinase I	HUMAN|HGNC=2451|UniProtKB=P48729	Casein kinase I isoform alpha	IDA	10617630	PubMed	PTHR11909:SF84	CASEIN KINASE I ISOFORM ALPHA
P00047	PDGF signaling pathway	P01168	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	ISS	1171954	gi	PTHR10048:SF14	PI-3 KINASE
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00005	Angiogenesis	P00219	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00586	Gq	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	IC	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00057	Wnt signaling pathway	P01453	Ebi	HUMAN|HGNC=29529|UniProtKB=Q9BZK7	F-box-like/WD repeat-containing protein TBL1XR1	IDA	11389839	PubMed	PTHR22846:SF40	F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN TBL1XR1
P00056	VEGF signaling pathway	P01407	Erk	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P04393	Ras Pathway	P04574	PLD	MOUSE|MGI=MGI=892877|UniProtKB=P97813	Phospholipase D2	IDA	9538008	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P00057	Wnt signaling pathway	P01446	Calcineurin	HUMAN|HGNC=9315|UniProtKB=P16298	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	IDA	12091710	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	IPI	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00017	DNA replication	P00527	Histones	DAPPU|EnsemblGenome=DAPPUDRAFT_231307|UniProtKB=E9H1C5	Histone H3	ISS	12413958	PubMed	PTHR11426:SF179	HISTONE H3.3
P05913	Enkephalin release	P05973	GPCR (i)	HUMAN|HGNC=8153|UniProtKB=P41143	Delta-type opioid receptor	ISS	12093103	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00944	Actin	BRAFL|Gene=BRAFLDRAFT_56687|UniProtKB=C3YC50	Putative uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01154	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P05731	GABA-B receptor II signaling	P05754	Ggamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00054	Toll receptor signaling pathway	P01347	MD-2	HUMAN|HGNC=17156|UniProtKB=Q9Y6Y9	Lymphocyte antigen 96	ISS			PTHR15218:SF0	LYMPHOCYTE ANTIGEN 96
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	CAEEL|WormBase=WBGene00002173|UniProtKB=Q9Y0A1	Inositol 1,4,5-trisphosphate receptor itr-1	IC	1849282	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00057	Wnt signaling pathway	P01472	Histone deacetylase	CAEEL|WormBase=WBGene00001835|UniProtKB=Q09440	Putative histone deacetylase 2	IDA	10485845	PubMed	PTHR10625:SF132	HISTONE DEACETYLASE 3
P04393	Ras Pathway	P04541	p90RSK	XENTR|Xenbase=XB-GENE-480947|UniProtKB=F6ZM17	Uncharacterized protein (Fragment)	ISS	10558991	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ORNAN|Ensembl=ENSOANG00000000460|UniProtKB=F7F4W9	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P02781	Threonine biosynthesis	P03190	Threonine synthase	ECOLI|EcoGene=EG11000|UniProtKB=P00934	Threonine synthase	ISS	11677608	PubMed	PTHR43455:SF2	THREONINE SYNTHASE
P00021	FGF signaling pathway	P00624	14-3-3	MONDO|Ensembl=ENSMODG00000013658|UniProtKB=F6TY10	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	MOUSE|MGI=MGI=88398|UniProtKB=Q9ERZ3	Muscarinic acetylcholine receptor M3	ISS	11166329	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00036	Interleukin signaling pathway	P00983	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MONDO|Ensembl=ENSMODG00000018204|UniProtKB=F6PGX6	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IGI	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00203	Erk	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00641	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	YEAST|SGD=S000001295|UniProtKB=P07278	cAMP-dependent protein kinase regulatory subunit	ISS	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01200	SHIP	BOVIN|Ensembl=ENSBTAG00000019167|UniProtKB=E1BBJ7	Uncharacterized protein	ISS	10610720	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00005	Angiogenesis	P00236	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MOUSE|MGI=MGI=2444552|UniProtKB=Q8BFZ3	Beta-actin-like protein 2	IC	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00029	Huntington disease	P00796	Kainate receptor	MACMU|Ensembl=ENSMMUG00000004886|UniProtKB=F7AGT9	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	MONDO|Ensembl=ENSMODG00000019001|UniProtKB=F7CP86	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06834	MAP3Ks	MOUSE|MGI=MGI=1346881|UniProtKB=Q60700	Mitogen-activated protein kinase kinase kinase 12	RCA			PTHR44359:SF1	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12
P00029	Huntington disease	P00796	Kainate receptor	CHICK|Ensembl=ENSGALG00000015835|UniProtKB=F1NZT2	Uncharacterized protein	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	9516481	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00053	T cell activation	P01322	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	TAS	20451058	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00217	STAT3	PANTR|Ensembl=ENSPTRG00000009200|UniProtKB=H2QD20	Signal transducer and activator of transcription	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00021	FGF signaling pathway	P00645	Rac	CANAL|CGD=CAL0000192612|UniProtKB=P0CY33	Cell division control protein 42 homolog	ISS			PTHR24072:SF192	CDC42 HOMOLOG
P04385	Histamine H1 receptor mediated signaling pathway	P04485	H1	PANTR|Gene=HRH1|UniProtKB=Q9N2B2	Histamine H1 receptor	ISS	11841575	PubMed	PTHR43914:SF2	HISTAMINE H1 RECEPTOR
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	BOVIN|Ensembl=ENSBTAG00000001575|UniProtKB=F1N6C0	Uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF311	CALMODULIN
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Ensembl=ENSBTAG00000009942|UniProtKB=E1BH60	Phosphoinositide phospholipase C	ISS			PTHR10336:SF84	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	RAT|RGD=621005|UniProtKB=Q08849	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	ENTHI|EnsemblGenome=EHI_197840|UniProtKB=C4M8K6	Rho family GTPase	ISS	12932731	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00029	Huntington disease	P00787	MAPKK4	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00034	Integrin signalling pathway	P00925	MEK	MACMU|Ensembl=ENSMMUG00000010904|UniProtKB=F7GLY5	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01449	Nemo-like Kinase	MONDO|Ensembl=ENSMODG00000019231|UniProtKB=F6RE45	Mitogen-activated protein kinase	ISS	10683140	PubMed	PTHR24055:SF179	SERINE/THREONINE-PROTEIN KINASE NLK
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P06213	DPP signaling pathway	P06282	DPP full length	DROME|FlyBase=FBgn0000490|UniProtKB=P07713	Protein decapentaplegic	IEA	http://flybase.org/reports/FBgn0000490.html	Website	PTHR11848:SF234	PROTEIN DECAPENTAPLEGIC
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04393	Ras Pathway	P04557	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CAEEL|WormBase=WBGene00004056|UniProtKB=Q8MXI4	Mitogen-activated protein kinase pmk-2	IDA	11274345	PubMed	PTHR24055:SF154	MITOGEN-ACTIVATED PROTEIN KINASE PMK-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00053	T cell activation	P01332	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	HUMAN|HGNC=1951|UniProtKB=P08172	Muscarinic acetylcholine receptor M2	TAS	10069496	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	IDA	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00207	Crk	PANTR|Ensembl=ENSPTRG00000014094|UniProtKB=H2R472	Uncharacterized protein	ISS	8649368	PubMed	PTHR19969:SF9	CRK-LIKE PROTEIN
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IGI	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00022	General transcription by RNA polymerase I	P00657	TBP	HUMAN|HGNC=11589|UniProtKB=P62380	TATA box-binding protein-like protein 1	ISS	600075	OMIM	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00059	p53 pathway	G04694	p110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	IDA	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000032222|UniProtKB=F7FW05	Uncharacterized protein	ISS	12441358	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00005	Angiogenesis	P00194	Paxillin	DROME|FlyBase=FBgn0041789|UniProtKB=Q2PDT4	Paxillin, isoform F	ISS			PTHR24216:SF8	PAXILLIN, ISOFORM F
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00034	Integrin signalling pathway	P00936	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	IPI	11292874	PubMed	PTHR10048:SF14	PI-3 KINASE
P02776	Serine glycine biosynthesis	P03160	Phosphoglycerate dehydrogenase	METAC|EnsemblGenome=MA_0592|UniProtKB=Q8TT47	D-3-phosphoglycerate dehydrogenase	ISS			PTHR42938:SF9	FORMATE DEHYDROGENASE 1-RELATED
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01202	p85	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	G01540	BDNF	BOVIN|Ensembl=ENSBTAG00000008134|UniProtKB=Q95106	Brain-derived neurotrophic factor	ISS	11408619	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P04398	p53 pathway feedback loops 2	P04658	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00018	EGF receptor signaling pathway	P00561	STAT	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	14755057	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P04393	Ras Pathway	P04559	Rac	BOVIN|Ensembl=ENSBTAG00000022927|UniProtKB=F1MCR0	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	IC	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	LEIMA|EnsemblGenome=LmjF.09.0910|UniProtKB=Q4QHT2	Putative calmodulin	ISS	9753452	PubMed	PTHR23050:SF245	AT16150P-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00047	PDGF signaling pathway	P01143	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01430	p53	HUMAN|HGNC=11998|UniProtKB=P04637	Cellular tumor antigen p53	IDA	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00012	Cadherin signaling pathway	P00462	Casein kinase II	CAEEL|WormBase=WBGene00002196|UniProtKB=P28548	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00046	Oxidative stress response	P01131	MKP5	RAT|RGD=1307146|UniProtKB=D3ZC16	Dual specificity phosphatase 22 (Predicted), isoform CRA_a	ISS			PTHR10159:SF29	DUAL SPECIFICITY PROTEIN PHOSPHATASE 22
P00049	Parkinson disease	P01238	14-3-3	MOUSE|MGI=MGI=1891917|UniProtKB=Q9CQV8	14-3-3 protein beta/alpha	ISS	1671102	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	BOVIN|Ensembl=ENSBTAG00000008497|UniProtKB=E1BIV2	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF179	REGULATOR OF G-PROTEIN SIGNALING 14
P00023	General transcription regulation	P00660	RNA Polymerase II	TETTS|EnsemblGenome=TTHERM_00193849|UniProtKB=A4VDR4	Conjugation stage-specific protein	ISS	2187864	PubMed	PTHR11800:SF2	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00010	B cell activation	P00384	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	G04694	p110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00640	PI3K	DROME|FlyBase=FBgn0015278|UniProtKB=Q7K3H0	LD28067p	IGI	8662856	PubMed	PTHR10048:SF64	LD28067P
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	MACMU|Ensembl=ENSMMUG00000012005|UniProtKB=F7H091	Metabotropic glutamate receptor 2 isoform a	ISS	12488551	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00029	Huntington disease	P00779	TBP	CAEBR|Gene=CBG09138|UniProtKB=A8X861	Protein CBR-TBP-1	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00010	B cell activation	P00380	fos	PANTR|Ensembl=ENSPTRG00000006553|UniProtKB=A5A6H0	C-fos	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01072	CHT1	CANLF|Ensembl=ENSCAFG00000002064|UniProtKB=E2RAJ0	Uncharacterized protein	ISS	12675135	PubMed	PTHR11819:SF129	HIGH AFFINITY CHOLINE TRANSPORTER 1
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P02738	De novo purine biosynthesis	P02909	GDP reductase	TRYB2|Gene=Tb11.v4.0006|UniProtKB=Q382Q1	Ribonucleoside-diphosphate reductase small chain	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00023	General transcription regulation	P00664	TFIIH complex	PANTR|Ensembl=ENSPTRG00000005604|UniProtKB=H2R726	Uncharacterized protein	ISS			PTHR12831:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3
P04393	Ras Pathway	P04558	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P06664	Gonadotropin-releasing hormone receptor pathway	P06737	p300	MOUSE|MGI=MGI=1276116|UniProtKB=B2RWS6	Histone acetyltransferase p300	RCA	10664585	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00477	GSK3beta	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00010	B cell activation	P00383	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00514	MLCK	CHICK|Gene=Mylk|UniProtKB=P11799	Myosin light chain kinase, smooth muscle	TAS	600922	OMIM	PTHR45480:SF1	MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00006	Apoptosis signaling pathway	P00274	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	ISS	97102676	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	TAKRU|Ensembl=ENSTRUG00000010260|UniProtKB=H2TMC5	Cystathionine beta-synthase	ISS			PTHR10314:SF132	CYSTATHIONINE BETA-SYNTHASE
P00054	Toll receptor signaling pathway	P01368	MKK2	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000007084|UniProtKB=H2Q9G5	Uncharacterized protein	ISS	10051575	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=3025|UniProtKB=P21917	D(4) dopamine receptor	IDA	12181435	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00018	EGF receptor signaling pathway	P00556	PLCgamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00029	Huntington disease	P00779	TBP	THEKO|EnsemblGenome=TK0132|UniProtKB=Q52366	TATA-box-binding protein	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ANOGA|EnsemblGenome=AGAP002127|UniProtKB=Q7PYV6	AGAP002127-PA	IC	14684598	PubMed	PTHR11937:SF195	BETA-CENTRACTIN
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00560	Raf-1	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS			PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	CAEBR|Gene=CBG16221|UniProtKB=A8XNV3	Protein CBG16221	ISS			PTHR11645:SF46	PYRROLINE-5-CARBOXYLATE REDUCTASE
P00010	B cell activation	P00380	fos	PANTR|Ensembl=ENSPTRG00000006553|UniProtKB=A5A6H0	C-fos	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	MOUSE|MGI=MGI=1338071|UniProtKB=O88351	Inhibitor of nuclear factor kappa-B kinase subunit beta	IDA	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	SYNY3|Gene=BAA18852|UniProtKB=P74732	Ribonucleoside-diphosphate reductase subunit beta	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00057	Wnt signaling pathway	P01453	Ebi	HUMAN|HGNC=11585|UniProtKB=O60907	F-box-like/WD repeat-containing protein TBL1X	IDA	11389839	PubMed	PTHR22846:SF2	F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN TBL1X
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P02770	Pyridoxal phosphate salvage pathway	P03123	Pyridoxine-5-phosphate oxidase	ANOGA|EnsemblGenome=AGAP002227|UniProtKB=Q7QK95	AGAP002227-PA	ISS			PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00021	FGF signaling pathway	P00633	Ras	DICDI|dictyBase=DDB_G0283537|UniProtKB=P32254	Ras-like protein rasS	IDA	8290260	PubMed	PTHR24070:SF380	RAS-LIKE PROTEIN RASS
P00019	Endothelin signaling pathway	P00591	PLCbeta	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IGI	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05915	Opioid proenkephalin pathway	P05994	G-protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000004742|UniProtKB=H2Q5K1	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00034	Integrin signalling pathway	P00925	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IDA	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00007	Axon guidance mediated by semaphorins	P00329	Sema4D	HUMAN|HGNC=10732|UniProtKB=Q92854	Semaphorin-4D	ISS			PTHR11036:SF18	SEMAPHORIN-4D
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	CHICK|Ensembl=ENSGALG00000014033|UniProtKB=E1BTS2	Uncharacterized protein	ISS	9869449	PubMed	PTHR24070:SF186	GTPASE KRAS
P00005	Angiogenesis	P00233	CSL	CANLF|Ensembl=ENSCAFG00000016387|UniProtKB=E2QV83	Uncharacterized protein	ISS	15187023	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04398	p53 pathway feedback loops 2	P04665	AKT	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	ISS	14526383	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	CHICK|Ensembl=ENSGALG00000027629|UniProtKB=Q5ZJ03	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00034	Integrin signalling pathway	P00924	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	RAT|RGD=2747|UniProtKB=P35349	Metabotropic glutamate receptor 6	IDA			PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00005	Angiogenesis	P00251	cPLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	IDA	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=1921982|UniProtKB=Q9D3G5	Syntaxin-11	IC	11067767	PubMed	PTHR19957:SF30	SYNTAXIN-11
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DICDI|dictyBase=DDB_G0289811|UniProtKB=Q54GX7	Actin-10	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	HUMAN|HGNC=9508|UniProtKB=P49768	Presenilin-1	IDA	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05734	Synaptic vesicle trafficking	P05780	Rab3A	XENTR|Xenbase=XB-GENE-489999|UniProtKB=Q28H43	RAB3A, member RAS oncogene family	ISS	9194562	PubMed	PTHR24073:SF532	RAS-RELATED PROTEIN RAB-3A
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	XENTR|Xenbase=XB-GENE-484003|UniProtKB=Q6P365	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	TAS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	G01531	BDNF	CHICK|Ensembl=ENSGALG00000012163|UniProtKB=P25429	Brain-derived neurotrophic factor	IDA	11408619	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P02783	Tryptophan biosynthesis	P03206	Anthranilate synthase	STRCO|Gene=CAB51435|UniProtKB=Q9S2U2	Putative anthranilate synthase component I	ISS			PTHR11236:SF9	ANTHRANILATE SYNTHASE COMPONENT 1
P00034	Integrin signalling pathway	P00944	Actin	BRAFL|Gene=BRAFLDRAFT_56687|UniProtKB=C3YC50	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	1333286	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00021	FGF signaling pathway	P00648	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	3755548	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01225	Synphilin	MOUSE|MGI=MGI=1915097|UniProtKB=Q99ME3	Synphilin-1	IDA	10319874	PubMed	PTHR22882:SF3	SYNPHILIN-1
P00005	Angiogenesis	P00193	SOS-1	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DICPU|Gene=DICPUDRAFT_93216|UniProtKB=F1A421	Guanine nucleotide-binding protein subunit beta	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00053	T cell activation	P01305	Calmodulin	MONDO|Ensembl=ENSMODG00000002696|UniProtKB=F7CY56	Uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF335	CALMODULIN, STRIATED MUSCLE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00056	VEGF signaling pathway	P01417	Raf	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00057	Wnt signaling pathway	P01428	Frizzled	MOUSE|MGI=MGI=108460|UniProtKB=Q61091	Frizzled-8	IDA	8717036	PubMed	PTHR11309:SF90	FRIZZLED-8
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02748	Isoleucine biosynthesis	P02995	Threonine dehydratase	DEIRA|EnsemblGenome=DR_0567|UniProtKB=Q9RWU8	L-threonine dehydratase	ISS			PTHR43714:SF1	THREONINE DEHYDRATASE, MITOCHONDRIAL
P04395	Vasopressin synthesis	P04589	Signal Peptidase	CHICK|Ensembl=ENSGALG00000002462|UniProtKB=Q5ZMQ3	Signal peptidase complex catalytic subunit SEC11	IC	2092035	PubMed	PTHR10806:SF8	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11A-RELATED
P06664	Gonadotropin-releasing hormone receptor pathway	P06757	JUN	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	RCA	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00005	Angiogenesis	P00212	EphR	MONDO|Ensembl=ENSMODG00000016114|UniProtKB=F7EAT1	Uncharacterized protein	ISS	9990854	PubMed	PTHR24416:SF123	EPHRIN TYPE-B RECEPTOR 2
P04398	p53 pathway feedback loops 2	P04664	cyclin E	HUMAN|HGNC=1589|UniProtKB=P24864	G1/S-specific cyclin-E1	IPI	12628165	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	ANOGA|EnsemblGenome=AGAP011807|UniProtKB=A0NGR7	AGAP011807-PA (Fragment)	ISS			PTHR11482:SF6	ORNITHINE DECARBOXYLASE 1-RELATED
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00591	PLCbeta	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00046	Oxidative stress response	P01134	cPLA2	DANRE|ZFIN=ZDB-GENE-990415-45|UniProtKB=P50392	Cytosolic phospholipase A2	TAS	94299545	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	CHICK|Ensembl=ENSGALG00000012894|UniProtKB=P30372	Muscarinic acetylcholine receptor M2	ISS	8100450	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00016	Cytoskeletal regulation by Rho GTPase	P00521	Profilin	HUMAN|HGNC=18627|UniProtKB=P60673	Profilin-3	ISS			PTHR13936:SF2	PROFILIN-3
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	ISS			PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	7937853	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P05730	Endogenous cannabinoid signaling	P05748	mGluR	MOUSE|MGI=MGI=1351342|UniProtKB=Q3UVX5	Metabotropic glutamate receptor 5	ISS	92317054	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	RCA	8787761	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	TAKRU|Ensembl=ENSTRUG00000007253|UniProtKB=H2SZQ1	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00014	Cholesterol biosynthesis	P00491	Hydroxymethyl glutaryl CoA reductase	HUMAN|HGNC=5006|UniProtKB=P04035	3-hydroxy-3-methylglutaryl-coenzyme A reductase	ISS	Q29512	SPACC	PTHR10572:SF2	3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00047	PDGF signaling pathway	P01164	PDK1/2	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	ISS	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00056	VEGF signaling pathway	P01401	HIF-1	HUMAN|HGNC=4910|UniProtKB=Q16665	Hypoxia-inducible factor 1-alpha	IGI	9606183	PubMed	PTHR23043:SF7	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_79607|UniProtKB=C3ZHN4	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00029	Huntington disease	P00775	Rac	DICPU|Gene=DICPUDRAFT_168754|UniProtKB=F0ZQR3	Rac1B, RHO family GTPase	ISS			PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00056	VEGF signaling pathway	P01411	Ras	DICPU|Gene=DICPUDRAFT_47179|UniProtKB=F0ZI47	Putative uncharacterized protein rasB	ISS	7997267	PubMed	PTHR24070:SF206	RAS-LIKE PROTEIN RASB
P00057	Wnt signaling pathway	P01433	SIAH-1	PANTR|Ensembl=ENSPTRG00000008094|UniProtKB=H2QB23	E3 ubiquitin-protein ligase	ISS	11389839	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	PANTR|Ensembl=ENSPTRG00000014058|UniProtKB=H2QL83	Clathrin heavy chain	ISS	9388255	PubMed	PTHR10292:SF6	CLATHRIN HEAVY CHAIN 2
P00012	Cadherin signaling pathway	P00471	Cadherin	BOVIN|Ensembl=ENSBTAG00000000061|UniProtKB=E1BCK4	Uncharacterized protein	ISS	8120095	PubMed	PTHR43912:SF8	PROTOCADHERIN-7
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00038	JAK/STAT signaling pathway	P01027	STAT	CANLF|Ensembl=ENSCAFG00000015346|UniProtKB=E2RE22	Signal transducer and activator of transcription	ISS	95188889	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00047	PDGF signaling pathway	P01153	GSK3	HUMAN|HGNC=29163|UniProtKB=Q9Y2I6	Ninein-like protein	ISS			PTHR18905:SF12	NINEIN-LIKE PROTEIN
P04393	Ras Pathway	P04572	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00020	FAS signaling pathway	P00601	c-Jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	YEAST|SGD=S000006124|UniProtKB=P06245	cAMP-dependent protein kinase type 2	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00021	FGF signaling pathway	P00627	ERK1-2	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	NAS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00053	T cell activation	P01322	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01162	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00045	Notch signaling pathway	P01120	NIcs	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00010	B cell activation	P00402	Jnk	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IDA	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04398	p53 pathway feedback loops 2	P04661	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01407	Erk	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	DICPU|Gene=DICPUDRAFT_92731|UniProtKB=F0ZWE6	Putative uncharacterized protein rasG	ISS	7997267	PubMed	PTHR24070:SF282	RAS GTPASE-RELATED
P00048	PI3 kinase pathway	P01192	p110	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01300	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04393	Ras Pathway	P04556	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IDA	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05760	AC	RAT|RGD=619966|UniProtKB=F1LQT1	Adenylate cyclase 7	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	IDA	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00034	Integrin signalling pathway	P00927	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12912997	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	PANTR|Ensembl=ENSPTRG00000000323|UniProtKB=H2PYA3	Uncharacterized protein	ISS	14645495	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P02770	Pyridoxal phosphate salvage pathway	P03122	Pyridoxamine kinase	MOUSE|MGI=MGI=1351869|UniProtKB=Q8K183	Pyridoxal kinase	ISS	20344886	gi	PTHR10534:SF2	PYRIDOXAL KINASE
P00021	FGF signaling pathway	P00634	MEKK1-5	MONDO|Ensembl=ENSMODG00000009983|UniProtKB=F6USY2	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IGI	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00048	PI3 kinase pathway	P01199	Galpha	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IC	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	CHICK|Ensembl=ENSGALG00000011558|UniProtKB=F1NWV6	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00038	JAK/STAT signaling pathway	P01031	PIAS	RAT|RGD=71056|UniProtKB=Q6AZ28	E3 SUMO-protein ligase PIAS2	ISS	8682149	PubMed	PTHR10782:SF12	E3 SUMO-PROTEIN LIGASE PIAS2
P00057	Wnt signaling pathway	P01431	LRP5/6	BOVIN|Ensembl=ENSBTAG00000005903|UniProtKB=F1N1K8	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=4595|UniProtKB=Q14832	Metabotropic glutamate receptor 3	IDA	20012997	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P05913	Enkephalin release	P05977	G-Protein (s)	BOVIN|Ensembl=ENSBTAG00000035697|UniProtKB=Q28024	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	PANTR|Ensembl=ENSPTRG00000012911|UniProtKB=H2QJE2	Uncharacterized protein	ISS	12473693	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CHICK|Ensembl=ENSGALG00000009844|UniProtKB=P68034	Actin, alpha cardiac muscle 1	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	HUMAN|HGNC=704|UniProtKB=O15143	Actin-related protein 2/3 complex subunit 1B	ISS	12473693	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CAEBR|Gene=CBG18319|UniProtKB=A8XSF1	Protein CBR-TBB-1	ISS	9454836	PubMed	PTHR11588:SF157	TUBULIN, BETA
P00053	T cell activation	P01322	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00053	T cell activation	P01305	Calmodulin	USTMA|Gene=UMAG_03910|UniProtKB=A0A0D1DU81	Chromosome 11, whole genome shotgun sequence	ISS			PTHR23050:SF245	AT16150P-RELATED
P00049	Parkinson disease	P01226	CDCrel-1	MONDO|Ensembl=ENSMODG00000016041|UniProtKB=F6YUL8	Uncharacterized protein (Fragment)	ISS			PTHR18884:SF67	SEPTIN-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	RCA	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00566	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CAEEL|WormBase=WBGene00001679|UniProtKB=P17343	Guanine nucleotide-binding protein subunit beta-1	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	CANLF|Ensembl=ENSCAFG00000012180|UniProtKB=F1PIB1	Uncharacterized protein	ISS	11212302	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CHICK|Ensembl=ENSGALG00000028102|UniProtKB=F1P3X4	Uncharacterized protein	IC	89264452	PubMed	PTHR13140:SF657	MYOSIN-4
P04398	p53 pathway feedback loops 2	P04665	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	BOVIN|Ensembl=ENSBTAG00000018270|UniProtKB=F1MGR9	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00799	JNK-2	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02759	Pyridoxal-5-phosphate biosynthesis	P03061	Pyridoxine-5-phosphate oxidase	PSEAE|EnsemblGenome=PA1049|UniProtKB=Q9I4S5	Pyridoxine/pyridoxamine 5'-phosphate oxidase	ISS	10984043	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00048	PI3 kinase pathway	P01181	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00047	PDGF signaling pathway	P01167	Ets	DROME|FlyBase=FBgn0005660|UniProtKB=P29776	DNA-binding protein D-ETS-6	ISS	15298723	PubMed	PTHR11849:SF267	DNA-BINDING PROTEIN D-ETS-6
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=1763|UniProtKB=P55283	Cadherin-4	IDA	8120095	PubMed	PTHR24027:SF81	CADHERIN-4
P00036	Interleukin signaling pathway	P00996	STAT	MONDO|Ensembl=ENSMODG00000014816|UniProtKB=F7CHH2	Signal transducer and activator of transcription	ISS	8732682	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	IC	14744463	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00005	Angiogenesis	P00188	Ets	MOUSE|MGI=MGI=95455|UniProtKB=P27577	Protein C-ets-1	ISS	15699632	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	TAS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00047	PDGF signaling pathway	P01154	Ras	NEUCR|EnsemblGenome=EFNCRG00000008769|UniProtKB=P22126	Protein ras-1	ISS	7997267	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	PANTR|Ensembl=ENSPTRG00000014418|UniProtKB=H2QLS0	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	IDA	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	NEUCR|EnsemblGenome=EFNCRG00000003107|UniProtKB=P34898	Serine hydroxymethyltransferase, cytosolic	ISS			PTHR11680:SF25	SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CIOIN|Ensembl=ENSCING00000001377|UniProtKB=F6SDC9	Uncharacterized protein	ISS			PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00018	EGF receptor signaling pathway	P00561	STAT	MOUSE|MGI=MGI=103038|UniProtKB=P42227	Signal transducer and activator of transcription 3	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00059	p53 pathway	P01486	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00922	Collagen	MACMU|Ensembl=ENSMMUG00000001467|UniProtKB=F7BJV7	Uncharacterized protein	ISS	10778855	PubMed	PTHR24023:SF569	COLLAGEN ALPHA-1 I  CHAIN
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00018	EGF receptor signaling pathway	P00543	ERK1-2	SCLS1|EnsemblGenome=SS1G_05445|UniProtKB=A7EJF2	Mitogen-activated protein kinase	ISS			PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DANRE|ZFIN=ZDB-GENE-030131-172|UniProtKB=Q6IQR3	Actin, alpha, cardiac muscle 1a	IDA	11889126	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P02746	Heme biosynthesis	P02982	Protoheme IX farnesyl transferase	MOUSE|MGI=MGI=1917633|UniProtKB=Q8CFY5	Protoheme IX farnesyltransferase, mitochondrial	ISS			PTHR43448:SF2	PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IC	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02721	ATP synthesis	P02796	F1 gamma	MONDO|Ensembl=ENSMODG00000016720|UniProtKB=F7CHH8	ATP synthase subunit gamma	ISS	9525963	PubMed	PTHR11693:SF22	ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL
P00005	Angiogenesis	P00203	Erk	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01306	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00005	Angiogenesis	P00196	VRAP	MACMU|Ensembl=ENSMMUG00000010917|UniProtKB=F7GLS8	Uncharacterized protein	ISS	10692392	PubMed	PTHR14388:SF9	SH2 DOMAIN-CONTAINING PROTEIN 2A
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01179	PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01370	TAK1	CHICK|Ensembl=ENSGALG00000015596|UniProtKB=E1C063	Uncharacterized protein	ISS	10683140	PubMed	PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P00005	Angiogenesis	P00239	Eph	PANTR|Ensembl=ENSPTRG00000006021|UniProtKB=H2Q7S4	Ephrin-B2	ISS	9990854	PubMed	PTHR11304:SF18	EPHRIN-B2
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MOUSE|MGI=MGI=88397|UniProtKB=Q9ERZ4	Muscarinic acetylcholine receptor M2	IDA			PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00010	B cell activation	P00375	Calmodulin	CANLF|Ensembl=ENSCAFG00000030049|UniProtKB=J9NWQ5	Uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF311	CALMODULIN
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014262|UniProtKB=F7BYS8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01159	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00018	EGF receptor signaling pathway	P00544	c-Cbl	MOUSE|MGI=MGI=88279|UniProtKB=P22682	E3 ubiquitin-protein ligase CBL	IGI	6680858	gi	PTHR23007:SF5	E3 UBIQUITIN-PROTEIN LIGASE CBL
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00897	SHIP2	HUMAN|HGNC=6080|UniProtKB=O15357	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	ISS	9824312	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	XENTR|Xenbase=XB-GENE-1014725|UniProtKB=F6UGQ3	Uncharacterized protein	ISS	11430913	PubMed	PTHR23122:SF40	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P00057	Wnt signaling pathway	P01451	Galpha	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	IDA	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00557	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IGI	12660731	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_56698|UniProtKB=C3XYC3	Putative uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00021	FGF signaling pathway	P00629	PP2A	PANTR|Ensembl=ENSPTRG00000001958|UniProtKB=H2Q137	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06830	AMPK	MOUSE|MGI=MGI=108411|UniProtKB=O54950	5'-AMP-activated protein kinase subunit gamma-1	RCA			PTHR13780:SF38	5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1
P02747	Histidine biosynthesis	P02992	Imidazol glycerol phosphate synthase	LEPIN|EnsemblGenome=LA_0125|UniProtKB=P59118	Imidazole glycerol phosphate synthase subunit HisH	ISS			PTHR42701:SF1	IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISH
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	MOUSE|MGI=MGI=99946|UniProtKB=Q61817	Cyclic AMP-responsive element-binding protein 3	ISS	1354612	PubMed	PTHR22952:SF100	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000016752|UniProtKB=H2QQP5	Cadherin 18, type 2	ISS	8120095	PubMed	PTHR24027:SF106	CADHERIN-18
P02738	De novo purine biosynthesis	P02907	dADP kinase	HALSA|EnsemblGenome=VNG_1160G|UniProtKB=P61136	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00053	T cell activation	P01306	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P00048	PI3 kinase pathway	P01185	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	BOVIN|Ensembl=ENSBTAG00000000438|UniProtKB=P32236	Gonadotropin-releasing hormone receptor	ISS			PTHR24241:SF22	GONADOTROPIN-RELEASING HORMONE RECEPTOR
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00054	Toll receptor signaling pathway	P01369	MKK1	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	RAT|RGD=2520|UniProtKB=P61169	D(2) dopamine receptor	ISS	1319557	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00012	Cadherin signaling pathway	P00474	Wnt	XENTR|Xenbase=XB-GENE-493706|UniProtKB=Q28IC7	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00052	TGF-beta signaling pathway	P01276	Co-Smads	ORNAN|Ensembl=ENSOANG00000008117|UniProtKB=F7F4A2	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P02772	Pyruvate metabolism	P03141	Citrate Synthetase	RAT|RGD=620330|UniProtKB=Q8VHF5	Citrate synthase, mitochondrial	TAS	2337600	PubMed	PTHR11739:SF8	CITRATE SYNTHASE, MITOCHONDRIAL
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=4598|UniProtKB=O15303	Metabotropic glutamate receptor 6	IDA	12351712	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00049	Parkinson disease	P01208	Hsp70	PANTR|Ensembl=ENSPTRG00000000563|UniProtKB=H2PYQ3	Heat shock 70kDa protein 5 (Glucose-regulated protein, 78kDa)	ISS	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	MOUSE|MGI=MGI=103038|UniProtKB=P42227	Signal transducer and activator of transcription 3	TAS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	NEUCR|EnsemblGenome=EFNCRG00000000159|UniProtKB=F5HH30	Guanine nucleotide-binding protein beta subunit	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00004	Alzheimer disease-presenilin pathway	P00148	Erb-B4 N-terminal fragment	PANTR|Ensembl=ENSPTRG00000012883|UniProtKB=H2QJC5	Receptor protein-tyrosine kinase	ISS	4884676	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00018	EGF receptor signaling pathway	P00560	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CANLF|Ensembl=ENSCAFG00000004930|UniProtKB=E2RFB5	Uncharacterized protein	ISS	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00005	Angiogenesis	P00230	PDGFR	BOVIN|Ensembl=ENSBTAG00000002804|UniProtKB=F1N759	Platelet-derived growth factor receptor beta	ISS	12374780	PubMed	PTHR24416:SF53	PLATELET-DERIVED GROWTH FACTOR RECEPTOR BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	PANTR|Gene=CHRM3|UniProtKB=Q9N2A4	Muscarinic acetylcholine receptor M3	TAS	11166329	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P05734	Synaptic vesicle trafficking	P05778	SNAP-25	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	RCA			PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	HUMAN|HGNC=1401|UniProtKB=Q02641	Voltage-dependent L-type calcium channel subunit beta-1	ISS	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00054	Toll receptor signaling pathway	P01358	ERK1	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00036	Interleukin signaling pathway	P00970	Interleukin	CANLF|Gene=IL6|UniProtKB=P41323	Interleukin-6	IC			PTHR45110:SF1	INTERLEUKIN-6
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ARATH|TAIR=AT2G43790|UniProtKB=Q39026	Mitogen-activated protein kinase 6	IDA			PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	DANRE|ZFIN=ZDB-GENE-990415-220|UniProtKB=Q9W6E3	Frizzled homolog 10	TAS	11212302	PubMed	PTHR11309:SF86	FRIZZLED-10
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00260	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DICPU|Gene=DICPUDRAFT_48914|UniProtKB=F0ZK40	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF154	ACTIN-17-RELATED
P00059	p53 pathway	P04630	PP2A	HUMAN|HGNC=9300|UniProtKB=P62714	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01165	SRF	CANLF|Ensembl=ENSCAFG00000001829|UniProtKB=F1PH12	Uncharacterized protein	ISS	15326221	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00053	T cell activation	P01305	Calmodulin	STRPU|EnsemblGenome=SPU_005033|UniProtKB=W4XNQ0	Uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF263	SUBFAMILY NOT NAMED
P00030	Hypoxia response via HIF activation	P00817	TOR	CANLF|Ensembl=ENSCAFG00000016648|UniProtKB=E2R2L2	Uncharacterized protein	ISS	7518356	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00046	Oxidative stress response	P01138	MKK4	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS	97236778	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00047	PDGF signaling pathway	P01148	Grb2	CAEEL|WormBase=WBGene00004774|UniProtKB=P29355	Sex muscle abnormal protein 5	ISS	8307166	PubMed	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00023	General transcription regulation	P00668	TFIIB	HALSA|EnsemblGenome=VNG_0315G|UniProtKB=Q9HSB3	Transcription initiation factor IIB 6	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01181	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00052	TGF-beta signaling pathway	P01275	P38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	8787761	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P05917	Opioid proopiomelanocortin pathway	P06008	ACTH	PANTR|Ensembl=ENSPTRG00000011721|UniProtKB=H2R8Y3	Uncharacterized protein	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IDA	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	TAKRU|Ensembl=ENSTRUG00000000304|UniProtKB=H2RKM1	Uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00019	Endothelin signaling pathway	P00566	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00018	EGF receptor signaling pathway	P00539	14-3-3	MOUSE|MGI=MGI=894689|UniProtKB=P62259	14-3-3 protein epsilon	ISS	98119747	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000002647|UniProtKB=F7DIB7	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P06959	CCKR signaling map	P07163	SRC @Galphaq	HUMAN|HGNC=11283|UniProtKB=P12931	Proto-oncogene tyrosine-protein kinase Src	RCA	16713446	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01438	PP2A	TAKRU|Ensembl=ENSTRUG00000003840|UniProtKB=H2S9H8	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DANRE|ZFIN=ZDB-GENE-030131-6206|UniProtKB=F1Q5K4	Uncharacterized protein	IEP	89264452	PubMed	PTHR13140:SF676	MYOSIN, HEAVY POLYPEPTIDE 2, FAST MUSCLE SPECIFIC
P00007	Axon guidance mediated by semaphorins	P00339	CRMP	HUMAN|HGNC=3016|UniProtKB=O14531	Dihydropyrimidinase-related protein 4	ISS			PTHR11647:SF55	DIHYDROPYRIMIDINASE-RELATED PROTEIN 4
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	PSEAE|EnsemblGenome=PA0441|UniProtKB=Q9I676	D-hydantoinase/dihydropyrimidinase	ISS	10984043	PubMed	PTHR11647:SF88	ISOASPARTYL DIPEPTIDASE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04393	Ras Pathway	P04560	AP1	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	11840290	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00566	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	12657601	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00015	Circadian clock system	P00505	Cry	MOUSE|MGI=MGI=1270859|UniProtKB=Q9R194	Cryptochrome-2	IDA	14507900	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P02763	Peptidoglycan biosynthesis	P03084	UDP-N-acetylmuramoylalanyl-D-glutamate 2,6-diaminopimelate ligase	CHLTR|EnsemblGenome=CT_269|UniProtKB=O84271	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase	ISS			PTHR23135:SF4	UDP-N-ACETYLMUAMOYLALANYL-D-GLUTAMATE-2,6-DIAMINOPIMELATE LIGASE-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	HUMAN|HGNC=143|UniProtKB=P68032	Actin, alpha cardiac muscle 1	IC	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00034	Integrin signalling pathway	P00906	Rap1	CHICK|Ensembl=ENSGALG00000006061|UniProtKB=F1P231	Uncharacterized protein	ISS	8576107	PubMed	PTHR24070:SF200	RAS-RELATED PROTEIN RAP-2C
P00053	T cell activation	P01307	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=16267|UniProtKB=Q9UBV4	Protein Wnt-16	IDA	8717036	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MONDO|Ensembl=ENSMODG00000024440|UniProtKB=F7DJJ2	Muscarinic acetylcholine receptor	ISS	10069496	PubMed	PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DROME|FlyBase=FBgn0000489|UniProtKB=P16912	Protein kinase DC2	IC	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DAPPU|EnsemblGenome=DAPPUDRAFT_228751|UniProtKB=E9HGF5	Cytoplasmatic actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P06664	Gonadotropin-releasing hormone receptor pathway	G06668	Rap1b	MOUSE|MGI=MGI=894315|UniProtKB=Q99JI6	Ras-related protein Rap-1b	RCA	1904317	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00018	EGF receptor signaling pathway	P00552	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MOUSE|MGI=MGI=87906|UniProtKB=P63260	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P02763	Peptidoglycan biosynthesis	P03090	N-Acetylglucosaminyl transferase	LEPIN|EnsemblGenome=LA_2050|UniProtKB=Q8F4J1	UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase	ISS			PTHR21015:SF22	GLYCOSYLTRANSFERASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MOUSE|MGI=MGI=2155600|UniProtKB=Q91Z83	Myosin-7	ISS	10938134	PubMed	PTHR13140:SF344	MYOSIN-7
P04395	Vasopressin synthesis	P04596	Endo Peptidase	GLOVI|Gene=BAC88566|UniProtKB=Q7NMZ0	Prolyl endopeptidase	IC	9695945	PubMed	PTHR42881:SF2	PROLYL ENDOPEPTIDASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	SCHPO|PomBase=SPBC2G5.02c|UniProtKB=O94281	Probable casein kinase II subunit beta-2	IDA	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00243	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P06959	CCKR signaling map	P07119	MAPK3	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	RCA	12239223	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00052	TGF-beta signaling pathway	P01290	TAB	MOUSE|MGI=MGI=1913763|UniProtKB=Q8CF89	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1	ISS	10838074	PubMed	PTHR13832:SF533	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000005620|UniProtKB=F6WDU9	Protocadherin-9	ISS	8120095	PubMed	PTHR43912:SF5	PROTOCADHERIN-9
P00019	Endothelin signaling pathway	P00575	furin	MOUSE|MGI=MGI=97513|UniProtKB=P23188	Furin	ISS	11861638	PubMed	PTHR42884:SF1	FURIN
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04398	p53 pathway feedback loops 2	P04665	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04568	MKK3/6	MOUSE|MGI=MGI=1346870|UniProtKB=P70236	Dual specificity mitogen-activated protein kinase kinase 6	RCA			PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P00036	Interleukin signaling pathway	P00981	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00008	Axon guidance mediated by Slit/Robo	P00350	SrGAP	HUMAN|HGNC=17382|UniProtKB=Q7Z6B7	SLIT-ROBO Rho GTPase-activating protein 1	RCA			PTHR14166:SF15	SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 1
P04393	Ras Pathway	P04570	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00025	Hedgehog signaling pathway	P00691	CBP	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00048	PI3 kinase pathway	P01196	PDK1	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	IDA	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05918	p38 MAPK pathway	P06026	MEKK4	MOUSE|MGI=MGI=1346875|UniProtKB=O08648	Mitogen-activated protein kinase kinase kinase 4	RCA	11730323	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00006	Apoptosis signaling pathway	P00276	TRAIL-R	MOUSE|MGI=MGI=1341090|UniProtKB=Q9QZM4	Tumor necrosis factor receptor superfamily member 10B	ISS	11498783	PubMed	PTHR23097:SF143	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10C-RELATED
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	DROME|FlyBase=FBgn0026439|UniProtKB=O77062	Excitatory amino acid transporter 1, isoform A	ISS	94365697	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00029	Huntington disease	P00780	Microtubule	MOUSE|MGI=MGI=1915472|UniProtKB=P68372	Tubulin beta-4B chain	IDA	12932731	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00018	EGF receptor signaling pathway	P00552	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	BOVIN|Ensembl=ENSBTAG00000002349|UniProtKB=P61267	Syntaxin-1B	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00049	Parkinson disease	P01242	Casein kinase I	ARATH|TAIR=AT3G03940|UniProtKB=Q9SQR8	Protein kinase family protein	IDA	10617630	PubMed	PTHR11909:SF131	CASEIN KINASE-LIKE PROTEIN-RELATED
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00927	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	14564011	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CANLF|Ensembl=ENSCAFG00000028654|UniProtKB=J9P702	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	XENTR|Xenbase=XB-GENE-480947|UniProtKB=F6ZM17	Uncharacterized protein (Fragment)	ISS	2779569	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04542	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	XENTR|Xenbase=XB-GENE-966302|UniProtKB=F6T2E7	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	RAT|RGD=70911|UniProtKB=P38444	Activin receptor type-2A	TAS	11252892	PubMed	PTHR23255:SF64	ACTIVIN RECEPTOR TYPE-2A
P00021	FGF signaling pathway	P00640	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00629	PP2A	CHICK|Ensembl=ENSGALG00000000235|UniProtKB=F1NBJ2	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B	ISS	137056	PubMed	PTHR11871:SF2	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B ALPHA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DICDI|dictyBase=DDB_G0279413|UniProtKB=P05987	cAMP-dependent protein kinase regulatory subunit	IC	92186968	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DROME|FlyBase=FBgn0024846|UniProtKB=O61443	Mitogen-activated protein kinase 14B	IDA	11707292	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DICDI|dictyBase=DDB_G0277143|UniProtKB=P36408	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	8170357	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00025	Hedgehog signaling pathway	P00691	CBP	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00046	Oxidative stress response	P01138	MKK4	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00016	Cytoskeletal regulation by Rho GTPase	P00507	Rho	DAPPU|EnsemblGenome=DAPPUDRAFT_301996|UniProtKB=E9HL06	Putative uncharacterized protein	ISS	7798239	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P04384	Gamma-aminobutyric acid synthesis	P04480	GABA aminotransferase	BOVIN|Gene=ABAT|UniProtKB=Q9BGI0	4-aminobutyrate aminotransferase, mitochondrial	ISS	8133261	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P05915	Opioid proenkephalin pathway	P05994	G-protein	ORNAN|Ensembl=ENSOANG00000003489|UniProtKB=F7FSE3	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00783	Rab8	RAT|RGD=621144|UniProtKB=P35280	Ras-related protein Rab-8A	RCA			PTHR24073:SF635	RAS-RELATED PROTEIN RAB-8A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	HUMAN|HGNC=669|UniProtKB=P08134	Rho-related GTP-binding protein RhoC	ISS	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P04371	5-Hydroxytryptamine biosynthesis	P04399	Tryptophan hydroxylase	MONDO|Ensembl=ENSMODG00000006704|UniProtKB=F7DGX6	Uncharacterized protein	ISS	14597720	PubMed	PTHR11473:SF23	TRYPTOPHAN 5-HYDROXYLASE 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	TAS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00059	p53 pathway	P04633	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01187	IR	CANLF|Ensembl=ENSCAFG00000018170|UniProtKB=E2RPM8	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF402	INSULIN RECEPTOR
P04395	Vasopressin synthesis	P04596	Endo Peptidase	HUMAN|HGNC=9358|UniProtKB=P48147	Prolyl endopeptidase	IC	9695945	PubMed	PTHR42881:SF2	PROLYL ENDOPEPTIDASE
P00054	Toll receptor signaling pathway	P01368	MKK2	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00053	T cell activation	P01332	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	PANTR|Ensembl=ENSPTRG00000012555|UniProtKB=H2QIU9	Serine/threonine-protein kinase receptor	ISS	9395284	PubMed	PTHR23255:SF69	ACTIVIN RECEPTOR TYPE-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04393	Ras Pathway	P04559	Rac	MONDO|Ensembl=ENSMODG00000003244|UniProtKB=F6THF0	Uncharacterized protein	ISS	97402517	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00014	Cholesterol biosynthesis	P00494	Squalene monooxygenas	ARATH|TAIR=AT4G37760|UniProtKB=Q8VYH2	Squalene epoxidase 3	ISS			PTHR10835:SF0	SQUALENE MONOOXYGENASE
P05734	Synaptic vesicle trafficking	P05778	SNAP-25	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12805548	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00038	JAK/STAT signaling pathway	P01027	STAT	PANTR|Ensembl=ENSPTRG00000009200|UniProtKB=H2QD20	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00052	TGF-beta signaling pathway	P01288	FKBP12	DEIRA|EnsemblGenome=DR_1839|UniProtKB=Q9RTC6	Peptidyl-prolyl cis-trans isomerase	ISS			PTHR43811:SF19	39 KDA FK506-BINDING NUCLEAR PROTEIN
P04393	Ras Pathway	P04542	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00269	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	PSEAE|EnsemblGenome=PA0342|UniProtKB=Q9I6F1	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00056	VEGF signaling pathway	P01411	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00034	Integrin signalling pathway	P00933	Crk	MACMU|Ensembl=ENSMMUG00000020477|UniProtKB=F6VK11	Crk-like protein	ISS	8649368	PubMed	PTHR19969:SF9	CRK-LIKE PROTEIN
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	BOVIN|Ensembl=ENSBTAG00000011198|UniProtKB=P61287	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	ISS	10433257	PubMed	PTHR11668:SF204	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-GAMMA CATALYTIC SUBUNIT
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00025	Hedgehog signaling pathway	P00682	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00054	Toll receptor signaling pathway	P01375	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	XENTR|Xenbase=XB-GENE-491938|UniProtKB=Q6DIV8	Actin, alpha 1, skeletal muscle	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IDA	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00054	Toll receptor signaling pathway	P01352	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01435	SWI/SNF	MONDO|Ensembl=ENSMODG00000014207|UniProtKB=F6TQC1	Uncharacterized protein	ISS	11532957	PubMed	PTHR12802:SF9	SWI/SNF COMPLEX SUBUNIT SMARCC1
P02760	PRPP biosynthesis	P03064	Phosphopentose mutase	DEIRA|EnsemblGenome=DR_2135|UniProtKB=Q9RSI9	Phosphopentomutase	ISS			PTHR21110:SF0	PHOSPHOPENTOMUTASE
P00012	Cadherin signaling pathway	P00466	EGFR	ANOGA|Gene=AgaP_AGAP008819|UniProtKB=Q7PPN5	Receptor protein-tyrosine kinase (Fragment)	ISS	21901296	PubMed	PTHR24416:SF95	EPIDERMAL GROWTH FACTOR RECEPTOR
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=1309999|UniProtKB=Q922R0	cAMP-dependent protein kinase catalytic subunit PRKX	IC	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CHICK|Ensembl=ENSGALG00000008898|UniProtKB=F1P2J9	Uncharacterized protein	IC	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00023	General transcription regulation	P00668	TFIIB	SCHPO|PomBase=SPBC13E7.10c|UniProtKB=Q9P6R0	Transcription factor IIIB 60 kDa subunit	ISS			PTHR11618:SF4	TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT
P04393	Ras Pathway	P04570	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IDA	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00018	EGF receptor signaling pathway	P00558	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	RAT|RGD=1304575|UniProtKB=B5DF98	Map3k3 protein	ISS	9006902	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	NEUCR|EnsemblGenome=EFNCRG00000008769|UniProtKB=P22126	Protein ras-1	ISS	7997267	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00760	Gtalpha	MOUSE|MGI=MGI=95778|UniProtKB=P20612	Guanine nucleotide-binding protein G(t) subunit alpha-1	IDA	10188796	PubMed	PTHR10218:SF67	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-1
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	TRIAD|EnsemblGenome=TriadG30170|UniProtKB=B3S6H7	Serine/threonine-protein phosphatase	ISS	8392016	PubMed	PTHR11668:SF402	SERINE/THREONINE-PROTEIN PHOSPHATASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05923	beta-ARR2	PANTR|Ensembl=ENSPTRG00000008601|UniProtKB=H2QBY1	Arrestin, beta 2	ISS	4757780	gi	PTHR11792:SF20	BETA-ARRESTIN-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	RCA	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00017	DNA replication	P00530	Top	YEAST|SGD=S000005032|UniProtKB=P06786	DNA topoisomerase 2	RCA			PTHR10169:SF38	DNA TOPOISOMERASE 2
P05916	Opioid prodynorphin pathway	P06002	G-protein	ANOGA|EnsemblGenome=AGAP005912|UniProtKB=Q7Q6D3	AGAP005912-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00035	Interferon-gamma signaling pathway	P00956	SOCS	MACMU|Ensembl=ENSMMUG00000012610|UniProtKB=F7F5C0	Uncharacterized protein	ISS	15032587	PubMed	PTHR44562:SF1	SUPPRESSOR OF CYTOKINE SIGNALING 6
P04398	p53 pathway feedback loops 2	G04712	P21	MACMU|Ensembl=ENSMMUG00000003210|UniProtKB=F7EEK4	Cyclin-dependent kinase inhibitor 1	ISS			PTHR10265:SF16	CYCLIN-DEPENDENT KINASE INHIBITOR 1
P00053	T cell activation	P01318	PKC-theta	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05918	p38 MAPK pathway	P06020	p38delta	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00047	PDGF signaling pathway	P01143	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9836512	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02746	Heme biosynthesis	P02983	Hydroxymethylbilane synthase	BACSU|EnsemblGenome=BSU28150|UniProtKB=P16616	Porphobilinogen deaminase	ISS			PTHR11557:SF4	SUBFAMILY NOT NAMED
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02922	Orotate phosphoribosyltransferase	SCHPO|PomBase=SPBC725.15|UniProtKB=O94331	Orotate phosphoribosyltransferase	ISS			PTHR19278:SF9	URIDINE 5'-MONOPHOSPHATE SYNTHASE
P00056	VEGF signaling pathway	P01407	Erk	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00575	furin	BOVIN|Gene=PCSK1|UniProtKB=Q9GLR1	Neuroendocrine convertase 1	ISS			PTHR42884:SF14	NEUROENDOCRINE CONVERTASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00108	ADAM10	HUMAN|HGNC=188|UniProtKB=O14672	Disintegrin and metalloproteinase domain-containing protein 10	IDA	10097139	PubMed	PTHR11905:SF4	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 10
P05918	p38 MAPK pathway	P06020	p38delta	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	12810719	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00019	Endothelin signaling pathway	P00586	Gq	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00029	Huntington disease	P00790	beta-Tubulin	THAPS|Gene=Thaps8069|UniProtKB=B8C8B4	Tubulin beta	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00238	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00021	FGF signaling pathway	P00641	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00833	RGS	RAT|RGD=3567|UniProtKB=P49799	Regulator of G-protein signaling 4	ISS	8756726	PubMed	PTHR10845:SF184	REGULATOR OF G-PROTEIN SIGNALING 4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	BOVIN|Ensembl=ENSBTAG00000008967|UniProtKB=P61223	Ras-related protein Rap-1b	ISS	1904317	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CIOIN|Ensembl=ENSCING00000007153|UniProtKB=L7N0T1	Uncharacterized protein	ISS			PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	RCA	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	CHICK|Ensembl=ENSGALG00000028102|UniProtKB=F1P3X4	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF657	MYOSIN-4
P00029	Huntington disease	P00780	Microtubule	EMENI|EnsemblGenome=CADANIAG00001443|UniProtKB=P10653	Tubulin beta-1 chain	IDA	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00029	Huntington disease	G01532	PolyQ HTT	MACMU|Ensembl=ENSMMUG00000008392|UniProtKB=F6VQZ3	Uncharacterized protein	ISS	9462744	PubMed	PTHR10170:SF10	HUNTINGTIN
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00059	p53 pathway	P04630	PP2A	BOVIN|Ensembl=ENSBTAG00000009245|UniProtKB=Q0P594	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00025	Hedgehog signaling pathway	P00682	PKA	NEUCR|EnsemblGenome=EFNCRG00000004240|UniProtKB=Q01386	cAMP-dependent protein kinase regulatory subunit	ISS	176892	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00053	T cell activation	P01320	PLC-gamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00010	B cell activation	P00371	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CAEEL|WormBase=WBGene00002040|UniProtKB=F0IWT2	Heavy chain, Unconventional Myosin	IC			PTHR13140:SF550	HEAVY CHAIN, UNCONVENTIONAL MYOSIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00029	Huntington disease	P00767	Pro-caspase 8	MOUSE|MGI=MGI=1261423|UniProtKB=O89110	Caspase-8	IDA	11788820	PubMed	PTHR10454:SF162	CASPASE-8
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	NEUCR|EnsemblGenome=EFNCRG00000001241|UniProtKB=Q7SDE2	Salicylaldehyde dehydrogenase	IC			PTHR43353:SF6	SUBFAMILY NOT NAMED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05730	Endogenous cannabinoid signaling	P05751	Galpha	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	RCA	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	ARATH|TAIR=AT2G43790|UniProtKB=Q39026	Mitogen-activated protein kinase 6	TAS			PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P00048	PI3 kinase pathway	P01177	P110ACT	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01465	Ggamma	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P02765	Phenylalanine biosynthesis	P03100	Chorismate mutase	SCHPO|PomBase=SPAC16E8.04c|UniProtKB=O13739	Probable chorismate mutase	ISS			PTHR21145:SF0	CHORISMATE MUTASE
P05918	p38 MAPK pathway	P06023	MEF	HUMAN|HGNC=6997|UniProtKB=Q14814	Myocyte-specific enhancer factor 2D	RCA			PTHR11945:SF23	MYOCYTE-SPECIFIC ENHANCER FACTOR 2D
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06805	MKK3/6	MOUSE|MGI=MGI=1346868|UniProtKB=O09110	Dual specificity mitogen-activated protein kinase kinase 3	RCA	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	BOVIN|Ensembl=ENSBTAG00000014299|UniProtKB=Q1RMJ6	Rho-related GTP-binding protein RhoC	ISS	12090470	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	ARATH|TAIR=AT3G58640|UniProtKB=Q94AB2	AT3g58640/F14P22_230	ISS			PTHR44514:SF1	MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE-LIKE PROTEIN-RELATED
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00020	FAS signaling pathway	P00610	MKK4	MOUSE|MGI=MGI=1346869|UniProtKB=P47809	Dual specificity mitogen-activated protein kinase kinase 4	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00012	Cadherin signaling pathway	P00466	EGFR	RAT|RGD=69323|UniProtKB=Q62799	Receptor tyrosine-protein kinase erbB-3	ISS	17432904	gi	PTHR24416:SF88	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	HUMAN|HGNC=6270|UniProtKB=Q92806	G protein-activated inward rectifier potassium channel 3	ISS	2433589	PubMed	PTHR11767:SF17	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 3
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00462	Casein kinase II	RAT|RGD=621663|UniProtKB=P19139	Casein kinase II subunit alpha	ISS	10617630	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00029	Huntington disease	P00807	Actin	ORNAN|Ensembl=ENSOANG00000007405|UniProtKB=F7CIV4	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00977	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00049	Parkinson disease	P01230	Src kinase	PANTR|Ensembl=ENSPTRG00000018521|UniProtKB=H2QTL3	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF296	TYROSINE-PROTEIN KINASE FRK
P00012	Cadherin signaling pathway	P00470	F-actin	CHICK|Ensembl=ENSGALG00000009621|UniProtKB=P60706	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CHICK|Ensembl=ENSGALG00000009405|UniProtKB=F1NKF1	Uncharacterized protein	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00021	FGF signaling pathway	P00642	MEK1-2	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IGI	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00048	PI3 kinase pathway	P01182	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	P01443	Phospholipase C	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	PANTR|Ensembl=ENSPTRG00000004148|UniProtKB=H2Q4I6	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF23	FRIZZLED-4
P04393	Ras Pathway	P04542	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=4595|UniProtKB=Q14832	Metabotropic glutamate receptor 3	IDA	12488551	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	DANRE|ZFIN=ZDB-GENE-020125-3|UniProtKB=E7F1V8	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	XENTR|Xenbase=XB-GENE-490883|UniProtKB=Q6NVA9	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P06664	Gonadotropin-releasing hormone receptor pathway	P06719	Ncoa3	MOUSE|MGI=MGI=1276535|UniProtKB=O09000	Nuclear receptor coactivator 3	RCA			PTHR10684:SF3	NUCLEAR RECEPTOR COACTIVATOR 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	IC	10704417	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00029	Huntington disease	G01535	PIG3	DICDI|dictyBase=DDB_G0272440|UniProtKB=Q75JT6	Uncharacterized protein	TAS	12932731	PubMed	PTHR43006:SF2	QUINONE OXIDOREDUCTASE PIG3
P00003	Alzheimer disease-amyloid secretase pathway	P00089	Pen-2	CAEEL|WormBase=WBGene00003975|UniProtKB=Q9U357	Gamma-secretase subunit pen-2	IDA	12110170	PubMed	PTHR16318:SF0	GAMMA-SECRETASE SUBUNIT PEN-2
P00049	Parkinson disease	P01227	20S proteasome	MOUSE|MGI=MGI=1347070|UniProtKB=Q9Z2U0	Proteasome subunit alpha type-7	ISS	12859888	PubMed	PTHR11599:SF40	PROTEASOME SUBUNIT ALPHA TYPE-7
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	PANTR|Ensembl=ENSPTRG00000010295|UniProtKB=H2QF07	Uncharacterized protein	ISS	1354612	PubMed	PTHR22952:SF98	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 3
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04398	p53 pathway feedback loops 2	P04658	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	IGI	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P02769	Purine metabolism	P03116	Xanthine Oxidase	PANTR|Ensembl=ENSPTRG00000011806|UniProtKB=H2QHQ2	Uncharacterized protein	ISS	11307944	PubMed	PTHR11908:SF80	XANTHINE DEHYDROGENASE/OXIDASE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06004	Mu or Delta receptor	MONDO|Ensembl=ENSMODG00000008382|UniProtKB=F7CDR6	Uncharacterized protein (Fragment)	ISS	11259487	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00006	Apoptosis signaling pathway	P00310	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014555|UniProtKB=F7GT55	Syntaxin-1A isoform 1	ISS	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00034	Integrin signalling pathway	P00949	Shc	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	IPI	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00047	PDGF signaling pathway	P01159	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PRIPA|Gene=PPA21756|UniProtKB=H3FHK9	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF255	TUBA7L PROTEIN
P00029	Huntington disease	P00775	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00006	Apoptosis signaling pathway	P00269	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00059	p53 pathway	P04616	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P02744	Fructose galactose metabolism	P02964	Hexose 1-P uridyltransferase	BOVIN|Ensembl=ENSBTAG00000015807|UniProtKB=Q58CX1	Galactose-1-phosphate uridylyltransferase	ISS	1610789	PubMed	PTHR11943:SF1	GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	RCA	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00036	Interleukin signaling pathway	P00996	STAT	PANTR|Ensembl=ENSPTRG00000005121|UniProtKB=H2Q6A5	Uncharacterized protein	ISS	94367369	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	IC	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ANOGA|EnsemblGenome=AGAP001407|UniProtKB=Q7PXH7	AGAP001407-PA	ISS			PTHR23073:SF31	26S PROTEASE REGULATORY SUBUNIT 10B
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00005	Angiogenesis	P00234	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	4504111	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00034	Integrin signalling pathway	P00912	Arp2/3	HUMAN|HGNC=708|UniProtKB=O15511	Actin-related protein 2/3 complex subunit 5	IPI	9230079	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00052	TGF-beta signaling pathway	P01275	P38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	TAKRU|Ensembl=ENSTRUG00000016241|UniProtKB=H2UX35	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF305	PROTEIN KINASE C
P00011	Blood coagulation	P00405	FVIII	CANLF|Gene=F8|UniProtKB=O18806	Coagulation factor VIII	ISS	2645493	gi	PTHR45309:SF1	COAGULATION FACTOR VIII
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00046	Oxidative stress response	P01135	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	TAS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00002	Alpha adrenergic receptor signaling pathway	P00078	Alpha1A/1B/1C	HUMAN|HGNC=278|UniProtKB=P35368	Alpha-1B adrenergic receptor	IC	11781138	PubMed	PTHR24248:SF17	ALPHA-1B ADRENERGIC RECEPTOR
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04556	Raf	DANRE|ZFIN=ZDB-GENE-040805-1|UniProtKB=Q1LYG2	Uncharacterized protein	ISS	3043188	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00053	T cell activation	P01307	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IPI	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00640	PI3K	CAEEL|WormBase=WBGene00006932|UniProtKB=Q9TXI7	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	21924698	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00017	DNA replication	P00536	DNA Topisomerase	HUMAN|HGNC=11990|UniProtKB=Q02880	DNA topoisomerase 2-beta	ISS			PTHR10169:SF36	DNA TOPOISOMERASE 2-BETA
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02916	dTMP kinase	PANTR|Ensembl=ENSPTRG00000013129|UniProtKB=H2QJR9	Deoxythymidylate kinase (Thymidylate kinase)	ISS			PTHR10344:SF1	THYMIDYLATE KINASE
P02779	Thiamin biosynthesis	P03170	Hydroxymethylpyrimidine phosphate kinase	BACSU|EnsemblGenome=BSU38020|UniProtKB=P39610	Pyridoxine kinase	ISS			PTHR20858:SF19	SUBFAMILY NOT NAMED
P05726	2-arachidonoylglycerol biosynthesis	P05735	PLA1	PANTR|Ensembl=ENSPTRG00000015258|UniProtKB=H2QN58	Uncharacterized protein	ISS			PTHR11610:SF111	PHOSPHOLIPASE A1 MEMBER A
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05913	Enkephalin release	P05974	G-Protein (i)	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00059	p53 pathway	G04694	p110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00221	JNK1	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00807	Actin	MOUSE|MGI=MGI=87909|UniProtKB=P62737	Actin, aortic smooth muscle	IDA	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P06959	CCKR signaling map	P07212	p85	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	RCA	11208554	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00260	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02746	Heme biosynthesis	P02980	Coproporphyrinogen Oxidase (oxygen dependent)	PSEAE|EnsemblGenome=PA0024|UniProtKB=P43898	Oxygen-dependent coproporphyrinogen-III oxidase	ISS			PTHR10755:SF0	OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	IDA	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	TAS	10514528	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	IDA	9603989	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	MACMU|Ensembl=ENSMMUG00000014817|UniProtKB=F6VXD8	Uncharacterized protein	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	MACMU|Ensembl=ENSMMUG00000011852|UniProtKB=F7H4T8	Receptor protein serine/threonine kinase	ISS			PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	HUMAN|HGNC=236|UniProtKB=O95622	Adenylate cyclase type 5	ISS	2491850	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00047	PDGF signaling pathway	P01153	GSK3	SCHPO|PomBase=SPAC1687.15|UniProtKB=Q10452	Protein kinase gsk3	ISS	21361340	gi	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P02782	Triacylglycerol metabolism	P03205	Triacylglycerol lipase	HUMAN|HGNC=6621|UniProtKB=Q05469	Hormone-sensitive lipase	ISS			PTHR23025:SF3	HORMONE-SENSITIVE LIPASE
P00036	Interleukin signaling pathway	P00983	Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	IC	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	HUMAN|HGNC=1954|UniProtKB=P08912	Muscarinic acetylcholine receptor M5	TAS	11166329	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00021	FGF signaling pathway	P00644	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	IPI	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00056	VEGF signaling pathway	P01411	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	9094314	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	SCLS1|EnsemblGenome=SS1G_03482|UniProtKB=A7EDU2	Guanine nucleotide-binding protein beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MONDO|Ensembl=ENSMODG00000012546|UniProtKB=F6PM16	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	CHICK|Ensembl=ENSGALG00000015835|UniProtKB=F1NZT2	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P05731	GABA-B receptor II signaling	P05760	AC	MOUSE|MGI=MGI=87917|UniProtKB=Q01341	Adenylate cyclase type 6	RCA	92357702	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00056	VEGF signaling pathway	P01407	Erk	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05916	Opioid prodynorphin pathway	P05999	provasopressin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00006	Apoptosis signaling pathway	P00321	HSP70	MONDO|Ensembl=ENSMODG00000012827|UniProtKB=F7DD51	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF239	HEAT SHOCK COGNATE 71 KDA PROTEIN
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	MACMU|Ensembl=ENSMMUG00000004886|UniProtKB=F7AGT9	Uncharacterized protein	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00057	Wnt signaling pathway	P01428	Frizzled	MOUSE|MGI=MGI=108571|UniProtKB=Q9EQD0	Frizzled-5	IDA	11212302	PubMed	PTHR11309:SF126	FRIZZLED-5
P00053	T cell activation	P01336	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00045	Notch signaling pathway	P01109	Aph-1	CAEEL|WormBase=WBGene00000147|UniProtKB=O45876	Gamma-secretase subunit aph-1	IPI	12471034	PubMed	PTHR12889:SF0	GAMMA-SECRETASE SUBUNIT APH-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00010	B cell activation	P00397	IKK	BOVIN|Ensembl=ENSBTAG00000007599|UniProtKB=Q95KV0	Inhibitor of nuclear factor kappa-B kinase subunit beta	IGI	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00001	Adrenaline and noradrenaline biosynthesis	P00068	amine translocator	DANRE|ZFIN=ZDB-GENE-070620-2|UniProtKB=A5D6R9	Transporter	ISS	12719981	PubMed	PTHR11616:SF125	SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER B 0 AT1
P00011	Blood coagulation	P00406	Fibrinogen	HUMAN|HGNC=3694|UniProtKB=P02679	Fibrinogen gamma chain	ISS	223170	gi	PTHR19143:SF338	FIBRINOGEN GAMMA CHAIN
P00005	Angiogenesis	P00211	GSK3beta	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	IDA	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00005	Angiogenesis	P00193	SOS-1	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00025	Hedgehog signaling pathway	P00682	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00008	Axon guidance mediated by Slit/Robo	P00344	Netrin	MONDO|Ensembl=ENSMODG00000008479|UniProtKB=F7G4D6	Uncharacterized protein	ISS	11356879	PubMed	PTHR10574:SF365	NETRIN-1
P00011	Blood coagulation	P00434	FXIa	MACMU|Ensembl=ENSMMUG00000020064|UniProtKB=F7GHR4	Uncharacterized protein	ISS	14270099	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P00030	Hypoxia response via HIF activation	P00823	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MACMU|Ensembl=ENSMMUG00000014807|UniProtKB=F6W548	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	ORNAN|Ensembl=ENSOANG00000000999|UniProtKB=F6WN02	Actin-related protein 2/3 complex subunit 5	ISS	9230079	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	RCA	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00056	VEGF signaling pathway	P01402	MEK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS			PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00045	Notch signaling pathway	P01113	Pen-2	MOUSE|MGI=MGI=109284|UniProtKB=Q61144	Presenilin-2	IGI	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00005	Angiogenesis	P00221	JNK1	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000008719|UniProtKB=F1MZX0	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00020	FAS signaling pathway	P00608	Pro-Caspase3	MACMU|Ensembl=ENSMMUG00000012053|UniProtKB=F7HFY2	Uncharacterized protein	ISS	11675509	PubMed	PTHR10454:SF198	CASPASE-3
P04398	p53 pathway feedback loops 2	P04668	p53	CANLF|Ensembl=ENSCAFG00000013961|UniProtKB=F1PL57	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00010	B cell activation	P00383	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P04395	Vasopressin synthesis	P04597	Signal Peptide	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P05734	Synaptic vesicle trafficking	P05773	Munc13	PANTR|Ensembl=ENSPTRG00000007093|UniProtKB=H2Q9G8	Uncharacterized protein	ISS	605836	OMIM	PTHR10480:SF2	PROTEIN UNC-13 HOMOLOG C
P00057	Wnt signaling pathway	P01451	Galpha	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02728	Arginine biosynthesis	P02841	argininosuccinate lyase	HALSA|EnsemblGenome=VNG_2436G|UniProtKB=Q9HMQ3	Argininosuccinate lyase	ISS			PTHR43814:SF1	ARGININOSUCCINATE LYASE
P00019	Endothelin signaling pathway	P00591	PLCbeta	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IGI	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00049	Parkinson disease	P01211	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01284	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	MONDO|Ensembl=ENSMODG00000018237|UniProtKB=F6PG65	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	MOUSE|MGI=MGI=109482|UniProtKB=P97445	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	11976940	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	TAS	10851062	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00053	T cell activation	P01333	cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00054	Toll receptor signaling pathway	P01369	MKK1	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00057	Wnt signaling pathway	P01428	Frizzled	MONDO|Ensembl=ENSMODG00000008701|UniProtKB=F6PWM3	Uncharacterized protein	ISS	12549854	PubMed	PTHR11309:SF22	FRIZZLED-3
P00049	Parkinson disease	P01242	Casein kinase I	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g161273|UniProtKB=A7RPJ6	Predicted protein	ISS	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00011	Blood coagulation	P00458	GP IIIa	CANLF|Ensembl=ENSCAFG00000013735|UniProtKB=F1PPG5	Integrin beta	ISS	20069419	gi	PTHR10082:SF25	INTEGRIN BETA-3
P05916	Opioid prodynorphin pathway	P05997	prodynorphin	MACMU|Ensembl=ENSMMUG00000009984|UniProtKB=F6R267	Beta-neoendorphin-dynorphin	ISS	131330	OMIM	PTHR11438:SF4	PROENKEPHALIN-B
P00034	Integrin signalling pathway	P00948	Rho	XENTR|Xenbase=XB-GENE-941426|UniProtKB=Q28HZ4	Novel Rho protein	ISS	12039949	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00048	PI3 kinase pathway	P01179	PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05973	GPCR (i)	MOUSE|MGI=MGI=97438|UniProtKB=P32300	Delta-type opioid receptor	ISS	12093103	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_116948|UniProtKB=C3YKS6	Putative uncharacterized protein	ISS			PTHR11937:SF359	SUBFAMILY NOT NAMED
P00049	Parkinson disease	P01213	Cyclin E	HUMAN|HGNC=1590|UniProtKB=O96020	G1/S-specific cyclin-E2	IDA	12628165	PubMed	PTHR10177:SF70	G1/S-SPECIFIC CYCLIN-E2
P00034	Integrin signalling pathway	P00936	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00467	alpha-catenin	CHICK|Ensembl=ENSGALG00000002447|UniProtKB=E1C7M7	Uncharacterized protein	ISS	1768802	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	22246731	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00005	Angiogenesis	P00189	Fzd	HUMAN|HGNC=4041|UniProtKB=Q9NPG1	Frizzled-3	IDA	11212302	PubMed	PTHR11309:SF22	FRIZZLED-3
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	CAEBR|Gene=CBG20640|UniProtKB=A8XY98	Protein CBG20640	ISS			PTHR20852:SF57	GLUTAMINE SYNTHETASE 2 CYTOPLASMIC
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	CHICK|Ensembl=ENSGALG00000017238|UniProtKB=F1NWG3	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P02762	Pentose phosphate pathway	P03079	Hexokinase	HUMAN|HGNC=23302|UniProtKB=Q2TB90	Putative hexokinase HKDC1	RCA			PTHR19443:SF28	HEXOKINASE HKDC1-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MONDO|Ensembl=ENSMODG00000008382|UniProtKB=F7CDR6	Uncharacterized protein (Fragment)	ISS	12093103	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00047	PDGF signaling pathway	P01170	PDGF	PANTR|Ensembl=ENSPTRG00000014392|UniProtKB=H2QLQ2	Uncharacterized protein	ISS			PTHR11633:SF2	PLATELET-DERIVED GROWTH FACTOR SUBUNIT B
P00012	Cadherin signaling pathway	P00470	F-actin	YARLI|EnsemblGenome=YALI0_D08272g|UniProtKB=Q9UVF3	Actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00029	Huntington disease	P00790	beta-Tubulin	PHYPA|Gene=PHYPADRAFT_110341|UniProtKB=Q6TYR6	Beta-tubulin 2	ISS	9454836	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04580	TRH Receptor	CHICK|Gene=TRHR|UniProtKB=O93603	Thyrotropin-releasing hormone receptor	ISS	7509436	PubMed	PTHR24243:SF115	THYROTROPIN-RELEASING HORMONE RECEPTOR
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	CHICK|Gene=CHRM4|UniProtKB=P17200	Muscarinic acetylcholine receptor M4	ISS	12181435	PubMed	PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00009	Axon guidance mediated by netrin	P00366	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	10802295	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	RCA	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01162	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02723	Adenine and hypoxanthine salvage pathway	P02807	Deoxyadenosine deaminase	CAEBR|Gene=CBG05749|UniProtKB=A8X1Q6	Protein CBG05749	ISS			PTHR11409:SF43	ADENOSINE DEAMINASE
P00021	FGF signaling pathway	P00645	Rac	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS	12874273	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	RAT|RGD=2733|UniProtKB=P42260	Glutamate receptor ionotropic, kainate 2	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00029	Huntington disease	P00805	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	11204774	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00057	Wnt signaling pathway	P01444	Wnt	DANRE|ZFIN=ZDB-GENE-980526-332|UniProtKB=P51028	Protein Wnt-8a	IDA	8717036	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P00047	PDGF signaling pathway	P01164	PDK1/2	YEAST|SGD=S000002898|UniProtKB=Q03407	Serine/threonine-protein kinase PKH1	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00052	TGF-beta signaling pathway	P01292	RSmads	TAKRU|Ensembl=ENSTRUG00000001329|UniProtKB=H2RSF1	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF36	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00260	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	HUMAN|HGNC=1392|UniProtKB=Q15878	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	8386525	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00047	PDGF signaling pathway	P01171	PLCgamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00035	Interferon-gamma signaling pathway	P00956	SOCS	PANTR|Ensembl=ENSPTRG00000005299|UniProtKB=H2Q6L9	Suppressor of cytokine signaling 2	ISS	15032587	PubMed	PTHR44396:SF2	SUPPRESSOR OF CYTOKINE SIGNALING 2
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MACMU|Ensembl=ENSMMUG00000014807|UniProtKB=F6W548	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04556	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	CANLF|Ensembl=ENSCAFG00000008544|UniProtKB=F1P625	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF25	MATRIX METALLOPROTEINASE-15
P00054	Toll receptor signaling pathway	P01352	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00034	Integrin signalling pathway	P00916	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04376	5HT4 type receptor mediated signaling pathway	P04426	K+ channel	MONDO|Ensembl=ENSMODG00000015769|UniProtKB=F6ZSC2	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00034	Integrin signalling pathway	P00940	Src	RAT|RGD=620795|UniProtKB=Q9WUD9	Proto-oncogene tyrosine-protein kinase Src	IPI	11078745	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	RAT|RGD=2025|UniProtKB=P68136	Actin, alpha skeletal muscle	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00021	FGF signaling pathway	P00644	p38	CAEBR|Gene=CBG01555|UniProtKB=A8WRD7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P05915	Opioid proenkephalin pathway	P05990	K+ channel	MONDO|Ensembl=ENSMODG00000015769|UniProtKB=F6ZSC2	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00060	Ubiquitin proteasome pathway	P01491	E2	PANTR|Ensembl=ENSPTRG00000013990|UniProtKB=H2QL51	Ubiquitin-conjugating enzyme E2G 2	ISS			PTHR24067:SF154	UBIQUITIN-CONJUGATING ENZYME E2 G2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	IC	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P02723	Adenine and hypoxanthine salvage pathway	P02810	Adenine phosphoribosyl transferase	ARATH|TAIR=AT1G80050|UniProtKB=Q42563	Adenine phosphoribosyltransferase 2	ISS			PTHR11776:SF12	ADENINE PHOSPHORIBOSYLTRANSFERASE 2-RELATED
P00057	Wnt signaling pathway	P01465	Ggamma	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00022	General transcription by RNA polymerase I	P00657	TBP	METAC|EnsemblGenome=MA_0278|UniProtKB=Q8TTZ7	TATA-box-binding protein 3	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02738	De novo purine biosynthesis	P02891	GDP kinase	BOVIN|Ensembl=ENSBTAG00000002689|UniProtKB=Q5E9Y9	Nucleoside diphosphate kinase 7	ISS			PTHR43109:SF2	NUCLEOSIDE DIPHOSPHATE KINASE 7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00020	FAS signaling pathway	P00601	c-Jun	CHICK|Gene=JUN|UniProtKB=P18870	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00023	General transcription regulation	P00660	RNA Polymerase II	RAT|RGD=708567|UniProtKB=O88828	DNA-directed RNA polymerases I, II, and III subunit RPABC2	ISS	12841771	gi	PTHR10773:SF12	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00047	PDGF signaling pathway	P01162	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8440264	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00034	Integrin signalling pathway	P00936	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05760	AC	BOVIN|Gene=ADCY1|UniProtKB=P19754	Adenylate cyclase type 1	RCA	2491850	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	BOVIN|Ensembl=ENSBTAG00000016420|UniProtKB=Q0VCX4	Catenin beta-1	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00045	Notch signaling pathway	G01541	E(spl)-C genes	PANTR|Ensembl=ENSPTRG00000018574|UniProtKB=H2QTP5	Uncharacterized protein	ISS			PTHR10985:SF88	HAIRY/ENHANCER-OF-SPLIT RELATED WITH YRPW MOTIF PROTEIN 2
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	CAEEL|WormBase=WBGene00017777|UniProtKB=Q09509	Putative folylpolyglutamate synthase	ISS			PTHR11136:SF5	FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL
P00047	PDGF signaling pathway	P01165	SRF	MOUSE|MGI=MGI=106658|UniProtKB=Q9JM73	Serum response factor	ISS	15647354	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P05913	Enkephalin release	G06046	preproenkephalin mRNA	HUMAN|HGNC=8831|UniProtKB=P01210	Proenkephalin-A	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ARATH|TAIR=AT5G09810|UniProtKB=P53492	Actin-7	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00059	p53 pathway	G04702	p53	HUMAN|HGNC=12003|UniProtKB=O15350	Tumor protein p73	TAS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00009	Axon guidance mediated by netrin	P00363	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00182	p38MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05760	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Ensembl=ENSBTAG00000009942|UniProtKB=E1BH60	Phosphoinositide phospholipase C	ISS			PTHR10336:SF84	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	IDA	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00367	NFAT	MACMU|Ensembl=ENSMMUG00000022596|UniProtKB=F6Z7T2	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF5	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 1
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	DANRE|ZFIN=ZDB-GENE-000328-3|UniProtKB=Q9YI00	Frizzled 8a protein	TAS	8717036	PubMed	PTHR11309:SF90	FRIZZLED-8
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00036	Interleukin signaling pathway	P00976	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	MACMU|Ensembl=ENSMMUG00000020819|UniProtKB=F7HSM1	Serine/threonine-protein phosphatase	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00223	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01465	Ggamma	BOVIN|Ensembl=ENSBTAG00000033526|UniProtKB=E1B8Q3	Guanine nucleotide binding protein 13, gamma-like	ISS	10391901	PubMed	PTHR15936:SF2	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-13
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04397	p53 pathway by glucose deprivation	P04641	Akt	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01142	p90RSK	MACMU|Ensembl=ENSMMUG00000019305|UniProtKB=F6S3T8	Ribosomal protein S6 kinase	ISS	15116068	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00010	B cell activation	P00391	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01395	TFIIE	ARATH|TAIR=AT1G03280|UniProtKB=Q93ZW3	Putative uncharacterized protein At1g03280	ISS			PTHR13097:SF7	NOVEL PROTEIN SIMILAR TO VERTEBRATE GENERAL TRANSCRIPTION FACTOR IIE POLYPEPTIDE 1 ALPHA 56KDA  GTF2E1
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MACMU|Ensembl=ENSMMUG00000003707|UniProtKB=F7GDQ6	Receptor protein serine/threonine kinase	ISS	10683140	PubMed	PTHR23255:SF58	ACTIVIN RECEPTOR TYPE-1C
P00018	EGF receptor signaling pathway	P00554	Shc	MACMU|Ensembl=ENSMMUG00000020357|UniProtKB=F6W915	SHC-transforming protein 3	ISS	98175964	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P00047	PDGF signaling pathway	P01171	PLCgamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00059	p53 pathway	P04630	PP2A	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	AQUAE|EnsemblGenome=aq_1505|UniProtKB=O67475	Ribonucleoside-diphosphate reductase subunit beta	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00053	T cell activation	P01332	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IDA	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00646	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	IPI	8262392	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CANLF|Ensembl=ENSCAFG00000019608|UniProtKB=E2R7K4	Uncharacterized protein	ISS	10391901	PubMed	PTHR15936:SF2	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-13
P00021	FGF signaling pathway	P00629	PP2A	ORYSJ|EnsemblGenome=OS10G0410600|UniProtKB=A3C4N5	Serine/threonine-protein phosphatase PP2A-4 catalytic subunit	ISS			PTHR11668:SF247	SUBFAMILY NOT NAMED
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	STRCO|Gene=CAB94611|UniProtKB=Q9K496	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	BOVIN|Ensembl=ENSBTAG00000016552|UniProtKB=A5PK70	Nucleoside diphosphate kinase	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	TAKRU|Ensembl=ENSTRUG00000016241|UniProtKB=H2UX35	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF305	PROTEIN KINASE C
P00008	Axon guidance mediated by Slit/Robo	P00355	Rho	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g243859|UniProtKB=A7S9Y5	Predicted protein	ISS	11973360	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	TAS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	BOVIN|Ensembl=ENSBTAG00000010111|UniProtKB=F1MJS2	Uncharacterized protein	ISS	9118222	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P05912	Dopamine receptor mediated signaling pathway	P05968	CLIC6	PANTR|Ensembl=ENSPTRG00000013882|UniProtKB=H2QZZ0	Chloride intracellular channel protein	ISS	14499480	PubMed	PTHR45476:SF1	CHLORIDE INTRACELLULAR CHANNEL PROTEIN 6
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHICK|Ensembl=ENSGALG00000008086|UniProtKB=Q5ZM58	Uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF46	ALPHA-CENTRACTIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P02756	N-acetylglucosamine metabolism	P03036	N-acetylglucosamine-6-phosphate deacetylase	CAEEL|WormBase=WBGene00010308|UniProtKB=P34480	N-acetylglucosamine-6-phosphate deacetylase	ISS			PTHR11113:SF14	N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	TAS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00034	Integrin signalling pathway	P00944	Actin	MONBE|Gene=37852|UniProtKB=A9V489	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	10218114	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00021	FGF signaling pathway	P00629	PP2A	PANTR|Ensembl=ENSPTRG00000006734|UniProtKB=H2Q8X8	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	TRYB2|Gene=Tb11.v4.0005|UniProtKB=Q382Q2	Ribonucleoside-diphosphate reductase small chain	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_79607|UniProtKB=C3ZHN4	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01407	Erk	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	HUMAN|HGNC=7778|UniProtKB=Q14934	Nuclear factor of activated T-cells, cytoplasmic 4	ISS	12787506	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	BOVIN|Ensembl=ENSBTAG00000003762|UniProtKB=A5PJS1	GNB5 protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00059	p53 pathway	P01486	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00549	EGF	MOUSE|MGI=MGI=99439|UniProtKB=Q05928	Probetacellulin	ISS			PTHR10740:SF3	PROBETACELLULIN
P00054	Toll receptor signaling pathway	P01355	AP1	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	3136397	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00034	Integrin signalling pathway	P00940	Src	MONDO|Ensembl=ENSMODG00000000247|UniProtKB=F6WR53	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00021	FGF signaling pathway	P00627	ERK1-2	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	IGI	9836510	gi	PTHR24055:SF330	SUBFAMILY NOT NAMED
P00046	Oxidative stress response	P01137	MNK1/2	MACMU|Ensembl=ENSMMUG00000020162|UniProtKB=F6TJV6	Uncharacterized protein	ISS	Q9BUB5	SPACC	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00572	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	TAS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00057	Wnt signaling pathway	P01456	beta-arrestin	MOUSE|MGI=MGI=99473|UniProtKB=Q8BWG8	Beta-arrestin-1	ISS	11742073	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00048	PI3 kinase pathway	P01199	Galpha	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04393	Ras Pathway	P04573	Elk-1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	IDA	14670631	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00018	EGF receptor signaling pathway	P00548	RKIP	PANTR|Ensembl=ENSPTRG00000005512|UniProtKB=H2Q6Z4	Phosphatidylethanolamine binding protein 1	ISS	92031654	PubMed	PTHR11362:SF28	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	HUMAN|HGNC=1960|UniProtKB=P36544	Neuronal acetylcholine receptor subunit alpha-7	IC			PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02775	Salvage pyrimidine ribonucleotides	P03150	Uridine kinase	SCHPO|PomBase=SPCC162.11c|UniProtKB=O74427	Uridine kinase	ISS			PTHR10285:SF123	URIDINE KINASE
P00021	FGF signaling pathway	P00644	p38	DROME|FlyBase=FBgn0024846|UniProtKB=O61443	Mitogen-activated protein kinase 14B	ISS	10851062	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00048	PI3 kinase pathway	P01206	14-3-3	BOVIN|Ensembl=ENSBTAG00000000236|UniProtKB=P63103	14-3-3 protein zeta/delta	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CANLF|Ensembl=ENSCAFG00000002617|UniProtKB=E2QUL1	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Ensembl=ENSCAFG00000010298|UniProtKB=P11616	Adenosine receptor A1	ISS	11781138	PubMed	PTHR24246:SF1	ADENOSINE RECEPTOR A1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	IDA	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00049	Parkinson disease	P01219	SAPK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01162	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IC	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00047	PDGF signaling pathway	P01173	STAT	PANTR|Ensembl=ENSPTRG00000005121|UniProtKB=H2Q6A5	Uncharacterized protein	ISS	94367369	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=8155|UniProtKB=P41146	Nociceptin receptor	IDA	11259487	PubMed	PTHR24229:SF11	NOCICEPTIN RECEPTOR
P00034	Integrin signalling pathway	P00951	Jnk	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	IDA	10851062	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	PANTR|Ensembl=ENSPTRG00000017291|UniProtKB=H2QRK9	Catenin (Cadherin-associated protein), alpha 1, 102kDa	ISS	9362521	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00034	Integrin signalling pathway	P00916	Ras	DANRE|ZFIN=ZDB-GENE-040808-67|UniProtKB=Q6AZA4	K-ras	ISS	10825661	PubMed	PTHR24070:SF186	GTPASE KRAS
P05913	Enkephalin release	P05972	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00036	Interleukin signaling pathway	P00973	PKB	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00019	Endothelin signaling pathway	P00581	Guanylate cyclase	CAEEL|WormBase=WBGene00001552|UniProtKB=Q6DNF7	Soluble guanylate cyclase gcy-32	ISS			PTHR11920:SF275	SOLUBLE GUANYLATE CYCLASE GCY-32
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	CANLF|Ensembl=ENSCAFG00000024151|UniProtKB=E2R795	Tyrosine-protein kinase receptor	ISS	11182407	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00053	T cell activation	P01332	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IDA	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	XENTR|Xenbase=XB-GENE-854877|UniProtKB=F7C949	Presenilin	ISS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	SCHPO|PomBase=SPAC1851.03|UniProtKB=P40232	Casein kinase II subunit beta	IDA	10617630	PubMed	PTHR11740:SF13	CASEIN KINASE II SUBUNIT BETA'
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IDA	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=1306800|UniProtKB=Q7TSK3	Protocadherin-8	ISS	8120095	PubMed	PTHR24028:SF46	PROTOCADHERIN-8
P04397	p53 pathway by glucose deprivation	P04641	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00187	beta catenin	MOUSE|MGI=MGI=88276|UniProtKB=Q02248	Catenin beta-1	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P02749	Leucine biosynthesis	P03001	3-Isopropylmalate dehydrogenase	PYRAE|EnsemblGenome=PAE1995|UniProtKB=Q8ZW34	3-isopropylmalate dehydrogenase (LeuB)	ISS			PTHR11835:SF48	HOMOISOCITRATE DEHYDROGENASE, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	TAS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00018	EGF receptor signaling pathway	P00551	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IGI	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	HUMAN|HGNC=4583|UniProtKB=Q16478	Glutamate receptor ionotropic, kainate 5	ISS	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00029	Huntington disease	P00796	Kainate receptor	MOUSE|MGI=MGI=95814|UniProtKB=Q60934	Glutamate receptor ionotropic, kainate 1	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	MONDO|Ensembl=ENSMODG00000011791|UniProtKB=F7CBU9	Phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P02738	De novo purine biosynthesis	P02899	GMP synthase	ANOGA|Gene=AgaP_AGAP010139|UniProtKB=Q7Q0V2	AGAP010139-PA	ISS			PTHR11922:SF2	GMP SYNTHASE  GLUTAMINE-HYDROLYZING
P00045	Notch signaling pathway	P01113	Pen-2	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00965	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000003364|UniProtKB=F6ZPQ4	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00025	Hedgehog signaling pathway	P00692	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00012	Cadherin signaling pathway	P00477	GSK3beta	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	MONDO|Ensembl=ENSMODG00000012785|UniProtKB=F6S0M5	Uncharacterized protein	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	BOVIN|Gene=SLC18A2|UniProtKB=Q27963	Synaptic vesicular amine transporter	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00036	Interleukin signaling pathway	P00990	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	CANLF|Ensembl=ENSCAFG00000015662|UniProtKB=E2RHY4	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	TAKRU|Ensembl=ENSTRUG00000016241|UniProtKB=H2UX35	Protein kinase C	ISS	11880265	PubMed	PTHR24356:SF305	PROTEIN KINASE C
P00019	Endothelin signaling pathway	P00589	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DROME|FlyBase=FBgn0259680|UniProtKB=P83099	Putative protein kinase C delta type homolog	ISS	2837282	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00019	Endothelin signaling pathway	P00567	PKG	CHICK|Ensembl=ENSGALG00000003805|UniProtKB=F1NE85	cGMP-dependent protein kinase	ISS	14568994	PubMed	PTHR24353:SF68	SUBFAMILY NOT NAMED
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00048	PI3 kinase pathway	P01177	P110ACT	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	DANRE|ZFIN=ZDB-GENE-081124-1|UniProtKB=F1QVX3	Uncharacterized protein	ISS			PTHR13140:SF728	MYOSIN HEAVY CHAIN, SKELETAL MUSCLE, ADULT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DICDI|dictyBase=DDB_G0289811|UniProtKB=Q54GX7	Actin-10	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IGI	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00951	Jnk	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	IDA	10514528	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00029	Huntington disease	P00780	Microtubule	DAPPU|EnsemblGenome=DAPPUDRAFT_302845|UniProtKB=E9GER1	Putative uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02748	Isoleucine biosynthesis	P02994	Branched chain amino acid aminotransferase	HUMAN|HGNC=977|UniProtKB=O15382	Branched-chain-amino-acid aminotransferase, mitochondrial	ISS			PTHR11825:SF39	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, MITOCHONDRIAL
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	HUMAN|HGNC=171|UniProtKB=Q04771	Activin receptor type-1	TAS	9395284	PubMed	PTHR23255:SF69	ACTIVIN RECEPTOR TYPE-1
P00036	Interleukin signaling pathway	P00976	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	ORNAN|Ensembl=ENSOANG00000011077|UniProtKB=F7FK62	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00010	B cell activation	P00381	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00025	Hedgehog signaling pathway	P00682	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	88234494	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	RAT|RGD=2029|UniProtKB=P80203	Serine/threonine-protein kinase receptor R3	TAS	9395284	PubMed	PTHR23255:SF66	SERINE/THREONINE-PROTEIN KINASE RECEPTOR R3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00630	RKIP	ARATH|TAIR=AT1G65480|UniProtKB=Q9SXZ2	Protein FLOWERING LOCUS T	ISS			PTHR11362:SF9	PROTEIN FLOWERING LOCUS T-RELATED
P00018	EGF receptor signaling pathway	P00540	MKK3,6	ORNAN|Ensembl=ENSOANG00000007732|UniProtKB=F6PXH5	Uncharacterized protein (Fragment)	ISS	97059154	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT3G45640|UniProtKB=Q39023	Mitogen-activated protein kinase 3	ISS	10851062	PubMed	PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00643	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00018	EGF receptor signaling pathway	P00552	Ras	RAT|RGD=1310793|UniProtKB=Q5BJU0	Protein Rras2	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00018	EGF receptor signaling pathway	P00563	Gab	MACMU|Ensembl=ENSMMUG00000015190|UniProtKB=F6WAT4	Uncharacterized protein	ISS	11739737	PubMed	PTHR12156:SF2	GRB2-ASSOCIATED-BINDING PROTEIN 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	BOVIN|Ensembl=ENSBTAG00000016552|UniProtKB=A5PK70	Nucleoside diphosphate kinase	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P00010	B cell activation	P00398	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	PANTR|Ensembl=ENSPTRG00000004321|UniProtKB=H2R3M8	Proprotein convertase subtilisin/kexin type 7	ISS			PTHR42884:SF12	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 7
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	CANLF|Ensembl=ENSCAFG00000016335|UniProtKB=J9NXY2	Uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF322	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BOVIN|Ensembl=ENSBTAG00000014614|UniProtKB=P62739	Actin, aortic smooth muscle	ISS	3487386	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	MACMU|Ensembl=ENSMMUG00000018136|UniProtKB=F7DHW8	G protein-activated inward rectifier potassium channel 2	ISS	12374786	PubMed	PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P00030	Hypoxia response via HIF activation	P00819	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04651	Ras	BOVIN|Ensembl=ENSBTAG00000009778|UniProtKB=E1BMX0	Uncharacterized protein	ISS	99084794	PubMed	PTHR24070:SF186	GTPASE KRAS
P00057	Wnt signaling pathway	P01465	Ggamma	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05734	Synaptic vesicle trafficking	P05774	NSF	BOVIN|Ensembl=ENSBTAG00000008442|UniProtKB=F1MZU2	Uncharacterized protein	ISS	601633	OMIM	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IDA	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00024	Glycolysis	P00680	Phosphoglyceromutase	HUMAN|HGNC=21731|UniProtKB=Q8N0Y7	Probable phosphoglycerate mutase 4	RCA			PTHR11931:SF14	PHOSPHOGLYCERATE MUTASE 4-RELATED
P00047	PDGF signaling pathway	P01143	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	9332390	PubMed	PTHR10202:SF13	PRESENILIN-2
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000004168|UniProtKB=H2R0J8	Uncharacterized protein	ISS	8120095	PubMed	PTHR24026:SF49	PROTOCADHERIN FAT 3
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	MOUSE|MGI=MGI=1915851|UniProtKB=Q8BML9	Glutaminyl-tRNA synthetase	ISS			PTHR43097:SF2	GLUTAMINYL-TRNA SYNTHETASE
P00019	Endothelin signaling pathway	P00587	Raf-1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IGI	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00018	EGF receptor signaling pathway	P00539	14-3-3	MOUSE|MGI=MGI=109484|UniProtKB=P63101	14-3-3 protein zeta/delta	ISS	92362864	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MOUSE|MGI=MGI=1928375|UniProtKB=Q9JM76	Actin-related protein 2/3 complex subunit 3	ISS	9359840	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	10514528	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IGI	176892	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00591	PLCbeta	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00057	Wnt signaling pathway	P01465	Ggamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	PANTR|Ensembl=ENSPTRG00000011333|UniProtKB=H2R5W8	Uncharacterized protein	ISS			PTHR13140:SF462	MYOSIN-14
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00005	Angiogenesis	P00218	STAT1	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	12191995	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00057	Wnt signaling pathway	P01448	CBP	ARATH|TAIR=AT1G16710|UniProtKB=Q9FWQ5	Histone acetyltransferase HAC12	ISS	10769018	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00029	Huntington disease	P00762	HAP1	MOUSE|MGI=MGI=1261831|UniProtKB=O35668	Huntingtin-associated protein 1	IPI	7477378	PubMed	PTHR15751:SF14	HUNTINGTIN-ASSOCIATED PROTEIN 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05915	Opioid proenkephalin pathway	P05994	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05915	Opioid proenkephalin pathway	P05994	G-protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00024	Glycolysis	P00679	Aldolase	MOUSE|MGI=MGI=2447811|UniProtKB=A6ZI46	Fructose-bisphosphate aldolase	ISS	74094688	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00057	Wnt signaling pathway	P01440	Cadherin	BOVIN|Ensembl=ENSBTAG00000018804|UniProtKB=E1BJ11	Uncharacterized protein	ISS	8120095	PubMed	PTHR24026:SF32	CADHERIN EGF LAG SEVEN-PASS G-TYPE RECEPTOR 2
P02783	Tryptophan biosynthesis	P03206	Anthranilate synthase	ARATH|TAIR=AT1G24909|UniProtKB=Q9FE37	Anthranilate synthase beta subunit	RCA			PTHR43418:SF6	ANTHRANILATE SYNTHASE BETA SUBUNIT-RELATED
P00050	Plasminogen activating cascade	P01255	Plasminogen	RAT|RGD=619893|UniProtKB=Q01177	Plasminogen	IDA	11928811	PubMed	PTHR24261:SF5	PLASMINOGEN
P00009	Axon guidance mediated by netrin	P00366	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	ISS	15668138	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00467	alpha-catenin	CANLF|Ensembl=ENSCAFG00000001315|UniProtKB=E2R9S7	Uncharacterized protein	ISS	9362521	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04407	K+ channel	HUMAN|HGNC=6283|UniProtKB=Q9NPC2	Potassium channel subfamily K member 9	ISS	15282272	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P02730	Asparagine and aspartate biosynthesis	P02853	Asparagine synthetase	PLAF7|EnsemblGenome=PFC0395w|UniProtKB=O77330	Asparagine synthetase [glutamine-hydrolyzing],putative	ISS			PTHR11772:SF2	ASPARAGINE SYNTHETASE
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BOVIN|Ensembl=ENSBTAG00000001668|UniProtKB=F1N6L8	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00054	Toll receptor signaling pathway	P01352	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00021	FGF signaling pathway	P00632	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00034	Integrin signalling pathway	P00910	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	7689150	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01131	MKP5	CHICK|Ensembl=ENSGALG00000011207|UniProtKB=Q7T2L9	Dual specificity protein phosphatase	TAS			PTHR10159:SF45	DUAL SPECIFICITY PROTEIN PHOSPHATASE 6
P00048	PI3 kinase pathway	G01543	IGFBP1	MACMU|Ensembl=ENSMMUG00000013765|UniProtKB=F6RF22	Uncharacterized protein	ISS	12493691	PubMed	PTHR11551:SF6	INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	ARATH|TAIR=AT2G39270|UniProtKB=Q84JF7	Probable adenylate kinase 6, chloroplastic	ISS			PTHR23359:SF152	ADENYLATE KINASE 6, CHLOROPLASTIC-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	8687401	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04393	Ras Pathway	P04565	MKK4/7	MACMU|Ensembl=ENSMMUG00000019842|UniProtKB=F7FU91	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00011	Blood coagulation	P00458	GP IIIa	CANLF|Ensembl=ENSCAFG00000013735|UniProtKB=F1PPG5	Integrin beta	ISS	280842	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P06959	CCKR signaling map	P07194	MAP2K1	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	RCA	9374631	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000021900|UniProtKB=F1MFK1	Uncharacterized protein	ISS	125549	gi	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P05918	p38 MAPK pathway	P06020	p38delta	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	RCA	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=1309423|UniProtKB=A0A0G2K528	Protein Stx16	ISS			PTHR19957:SF83	SYNTAXIN-16
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	BOVIN|Ensembl=ENSBTAG00000020079|UniProtKB=F1N3T0	Uncharacterized protein	ISS	9305639	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IGI	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	TAS	9603989	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00052	TGF-beta signaling pathway	P01286	TGFbeta	HUMAN|HGNC=11768|UniProtKB=P61812	Transforming growth factor beta-2	TAS	9759503	PubMed	PTHR11848:SF141	TRANSFORMING GROWTH FACTOR BETA-2
P00018	EGF receptor signaling pathway	P00561	STAT	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	12707323	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	PLAF7|EnsemblGenome=PF13_0140|UniProtKB=Q8IE69	Dihydrofolate synthase/folylpolyglutamate synthase	ISS			PTHR11136:SF0	DIHYDROFOLATE SYNTHETASE-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	IDA	10514528	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00037	Ionotropic glutamate receptor pathway	P01026	KA	PANTR|Ensembl=ENSPTRG00000011042|UniProtKB=H2QGF5	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00005	Angiogenesis	P00225	MEK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS			PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00049	Parkinson disease	P01238	14-3-3	DANRE|ZFIN=ZDB-GENE-011115-1|UniProtKB=Q6PC29	14-3-3 protein gamma-1	ISS	9507245	gi	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IDA	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00024	Glycolysis	P00679	Aldolase	MOUSE|MGI=MGI=1931052|UniProtKB=A6ZI47	Fructose-bisphosphate aldolase	ISS	84261525	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00021	FGF signaling pathway	P00645	Rac	CHICK|Ensembl=ENSGALG00000002859|UniProtKB=F6UBD2	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000006342|UniProtKB=H2Q8A8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00021	FGF signaling pathway	P00643	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01447	Dishevelled	PANTR|Gene=DVL1|UniProtKB=Q5IS48	Segment polarity protein dishevelled homolog DVL-1	ISS	7906389	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00059	p53 pathway	G04694	p110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00645	Rac	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS	15470041	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	IGI	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00036	Interleukin signaling pathway	P00965	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00627	ERK1-2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P06664	Gonadotropin-releasing hormone receptor pathway	P06757	JUN	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	RCA	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=1261834|UniProtKB=O70283	Protein Wnt-2b	TAS	11266476	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00021	FGF signaling pathway	P00623	FGF	PANTR|Ensembl=ENSPTRG00000022533|UniProtKB=H2R396	Fibroblast growth factor	ISS	12851399	PubMed	PTHR11486:SF27	FIBROBLAST GROWTH FACTOR 16
P00012	Cadherin signaling pathway	P00470	F-actin	CAEBR|Gene=CBG23091|UniProtKB=A8Y4Q9	Protein CBR-ACT-2	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00060	Ubiquitin proteasome pathway	P01492	E1	MOUSE|MGI=MGI=98890|UniProtKB=Q02053	Ubiquitin-like modifier-activating enzyme 1	ISS			PTHR10953:SF155	UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	MACMU|Ensembl=ENSMMUG00000009962|UniProtKB=F6RBM2	Thyroid stimulating hormone beta subunit	ISS	3017658	PubMed	PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	MOUSE|MGI=MGI=2442252|UniProtKB=Q8VI56	Low-density lipoprotein receptor-related protein 4	IDA	11907044	PubMed	PTHR44017:SF4	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4
P00034	Integrin signalling pathway	P00948	Rho	MOUSE|MGI=MGI=1921444|UniProtKB=P61588	Rho-related GTP-binding protein RhoE	ISS	11973360	PubMed	PTHR24072:SF24	RHO-RELATED GTP-BINDING PROTEIN RHOE
P04393	Ras Pathway	P04557	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00056	VEGF signaling pathway	P01418	Paxillin	CANLF|Ensembl=ENSCAFG00000016896|UniProtKB=E2RTE0	Uncharacterized protein	ISS			PTHR24216:SF27	TRANSFORMING GROWTH FACTOR BETA-1-INDUCED TRANSCRIPT 1 PROTEIN
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CHICK|Ensembl=ENSGALG00000008586|UniProtKB=F1NYB1	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00048	PI3 kinase pathway	P01181	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	TAS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MOUSE|MGI=MGI=88396|UniProtKB=P12657	Muscarinic acetylcholine receptor M1	IDA	11166329	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	ISS	91298951	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000023046|UniProtKB=F6V829	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00057	Wnt signaling pathway	P01440	Cadherin	XENTR|Xenbase=XB-GENE-1011620|UniProtKB=F7BBY2	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF84	CADHERIN-20
P00021	FGF signaling pathway	P00646	RasGAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	11847220	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	RCA	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	CANLF|Ensembl=ENSCAFG00000001097|UniProtKB=E2RCX6	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00023	General transcription regulation	P00669	TFIIEalpha	HUMAN|HGNC=4650|UniProtKB=P29083	General transcription factor IIE subunit 1	IGI	189962	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00047	PDGF signaling pathway	P01153	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00036	Interleukin signaling pathway	P00981	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	CHICK|Gene=CTNNA2|UniProtKB=P30997	Catenin alpha-2	TAS	9362521	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	BOVIN|Ensembl=ENSBTAG00000010837|UniProtKB=F1N3N9	Uncharacterized protein	ISS	12898568	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	XENTR|Xenbase=XB-GENE-494200|UniProtKB=F7CS79	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	IDA	10851062	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00029	Huntington disease	P00808	Caspase 8	CHICK|Ensembl=ENSGALG00000008355|UniProtKB=F1NXP6	Uncharacterized protein	IDA	8681376	PubMed	PTHR10454:SF162	CASPASE-8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	BOVIN|Ensembl=ENSBTAG00000025471|UniProtKB=Q06599	Tumor necrosis factor	ISS	11911478	PubMed	PTHR11471:SF23	TUMOR NECROSIS FACTOR
P00004	Alzheimer disease-presenilin pathway	P00121	CD44 intracellular fragment	MOUSE|MGI=MGI=88338|UniProtKB=P15379	CD44 antigen	IDA	12223485	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P02748	Isoleucine biosynthesis	P02997	Acetolactate synthase	CANLF|Ensembl=ENSCAFG00000016130|UniProtKB=F1Q255	Uncharacterized protein	ISS			PTHR18968:SF155	ACETOLACTATE SYNTHASE-LIKE PROTEIN
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00047	PDGF signaling pathway	P01162	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	CHLTR|EnsemblGenome=CT_828|UniProtKB=O84835	Ribonucleoside-diphosphate reductase subunit beta	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	DAPPU|EnsemblGenome=DAPPUDRAFT_306746|UniProtKB=E9GYE9	Putative uncharacterized protein	ISS	9658176	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	TAS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00034	Integrin signalling pathway	P00944	Actin	XENTR|Xenbase=XB-GENE-491618|UniProtKB=Q6P378	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00029	Huntington disease	P00771	Sin3A	RAT|RGD=1311598|UniProtKB=A0A0G2K3H5	Protein Sin3a	ISS	10441327	PubMed	PTHR12346:SF2	PAIRED AMPHIPATHIC HELIX PROTEIN SIN3A
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00383	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00566	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	TAS	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CHICK|Ensembl=ENSGALG00000002098|UniProtKB=F1P0L4	Uncharacterized protein	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00519	ROCK	CHICK|Ensembl=ENSGALG00000016451|UniProtKB=F1NK88	Rho-associated protein kinase	ISS			PTHR22988:SF28	RHO-ASSOCIATED PROTEIN KINASE 2
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00217	STAT3	BOVIN|Gene=STAT3|UniProtKB=P61635	Signal transducer and activator of transcription 3	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P05916	Opioid prodynorphin pathway	P06002	G-protein	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00629	PP2A	HUMAN|HGNC=9313|UniProtKB=Q16537	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	IDA	10092233	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P02781	Threonine biosynthesis	P03189	Aspartate kinase	METAC|EnsemblGenome=MA_0131|UniProtKB=Q8TUD6	Aspartokinase	ISS			PTHR21499:SF37	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00128	Erb-B4	PANTR|Ensembl=ENSPTRG00000012883|UniProtKB=H2QJC5	Receptor protein-tyrosine kinase	ISS	4884676	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00059	p53 pathway	G01581	BAX	RAT|RGD=2192|UniProtKB=Q63690	Apoptosis regulator BAX	ISS	11099028	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P00011	Blood coagulation	P00434	FXIa	HUMAN|HGNC=3551|UniProtKB=P00740	Coagulation factor IX	ISS	14270099	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P00034	Integrin signalling pathway	P00916	Ras	MONDO|Ensembl=ENSMODG00000025248|UniProtKB=F7F5X1	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00010	B cell activation	P00384	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IDA	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00047	PDGF signaling pathway	P01173	STAT	MONDO|Ensembl=ENSMODG00000014816|UniProtKB=F7CHH2	Signal transducer and activator of transcription	ISS	8732682	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00055	Transcription regulation by bZIP transcription factor	P01386	TFIIEbeta	YEAST|SGD=S000001770|UniProtKB=P36145	Transcription initiation factor IIE subunit beta	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-486685|UniProtKB=F6VT32	Protein kinase C	ISS	11880265	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05916	Opioid prodynorphin pathway	P06002	G-protein	DROME|FlyBase=FBgn0001122|UniProtKB=P16378	G protein alpha o subunit	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00029	Huntington disease	P00780	Microtubule	PANTR|Ensembl=ENSPTRG00000017939|UniProtKB=Q7JJU6	Tubulin beta chain	ISS	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00021	FGF signaling pathway	P00629	PP2A	CANLF|Ensembl=ENSCAFG00000006453|UniProtKB=F6X958	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04398	p53 pathway feedback loops 2	P04661	PI3K	SCHPO|PomBase=SPAC458.05|UniProtKB=P50520	Phosphatidylinositol 3-kinase vps34	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00052	TGF-beta signaling pathway	P01286	TGFbeta	HUMAN|HGNC=1068|UniProtKB=O95972	Bone morphogenetic protein 15	TAS	9759503	PubMed	PTHR11848:SF22	BONE MORPHOGENETIC PROTEIN 15
P00047	PDGF signaling pathway	P01163	c-Jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00046	Oxidative stress response	P01125	Stat1	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	TAS	12191995	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	IC	11535291	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00036	Interleukin signaling pathway	P00973	PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12539654	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00046	Oxidative stress response	P01135	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IGI	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MACMU|Ensembl=ENSMMUG00000002409|UniProtKB=F6PPH8	Acetylcholine receptor subunit epsilon	ISS			PTHR18945:SF59	ACETYLCHOLINE RECEPTOR SUBUNIT EPSILON
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000010095|UniProtKB=H2QEN8	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF323	CADHERIN-19
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	BOVIN|Ensembl=ENSBTAG00000010191|UniProtKB=Q08E52	Serine/threonine-protein kinase PAK 1	ISS	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00021	FGF signaling pathway	P00629	PP2A	PANTR|Ensembl=ENSPTRG00000017238|UniProtKB=H2QRH7	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00052	TGF-beta signaling pathway	P01275	P38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00020	FAS signaling pathway	P00601	c-Jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	ARATH|TAIR=AT4G38530|UniProtKB=Q56W08	Phosphoinositide phospholipase C 3	TAS			PTHR10336:SF105	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=4404|UniProtKB=P59768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IDA	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00021	FGF signaling pathway	P00642	MEK1-2	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00020	FAS signaling pathway	P00615	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	DANRE|Ensembl=ENSDARG00000006900|UniProtKB=B0UXP9	Inosine-5'-monophosphate dehydrogenase 2	ISS			PTHR11911:SF121	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2
P00010	B cell activation	P00373	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00896	Insulin IGF	MACMU|Ensembl=ENSMMUG00000002235|UniProtKB=F6VZY3	Uncharacterized protein	ISS			PTHR11454:SF4	INSULIN-LIKE GROWTH FACTOR I
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IDA	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00057	Wnt signaling pathway	P01447	Dishevelled	MOUSE|MGI=MGI=94941|UniProtKB=P51141	Segment polarity protein dishevelled homolog DVL-1	ISS	7906389	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P00060	Ubiquitin proteasome pathway	P01491	E2	CHICK|Ensembl=ENSGALG00000020793|UniProtKB=E1BQY2	Uncharacterized protein	ISS			PTHR24068:SF63	UBIQUITIN-CONJUGATING ENZYME E2 E3
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IGI	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	RAT|RGD=621060|UniProtKB=O88777	Presenilin-2	IDA	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347736|UniProtKB=E9FRT1	Muscle-specific actin	ISS	10974003	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00036	Interleukin signaling pathway	P00970	Interleukin	BOVIN|Ensembl=ENSBTAG00000016284|UniProtKB=P26895	Interleukin-7	ISS	1333837	PubMed	PTHR45542:SF1	INTERLEUKIN-7
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	TAS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000000365|UniProtKB=F6R9F4	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00021	FGF signaling pathway	P00627	ERK1-2	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=1351343|UniProtKB=Q5NCH9	Metabotropic glutamate receptor 6	ISS	9407094	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	RAT|RGD=1308937|UniProtKB=D3ZCG5	Protein Mmp15	ISS	12834808	PubMed	PTHR10201:SF25	MATRIX METALLOPROTEINASE-15
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DICDI|dictyBase=DDB_G0275023|UniProtKB=Q553U6	Putative actin-22	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00057	Wnt signaling pathway	P01472	Histone deacetylase	XENTR|Xenbase=XB-GENE-481106|UniProtKB=Q28DV3	Histone deacetylase 3	ISS	10485845	PubMed	PTHR10625:SF132	HISTONE DEACETYLASE 3
P02723	Adenine and hypoxanthine salvage pathway	P02809	Xanthine dehydrogenase	HUMAN|HGNC=12805|UniProtKB=P47989	Xanthine dehydrogenase/oxidase	ISS	8708081	PubMed	PTHR11908:SF80	XANTHINE DEHYDROGENASE/OXIDASE
P00036	Interleukin signaling pathway	P00973	PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02784	Tyrosine biosynthesis	P03213	Aromatic amino acid aminotransferase	RAT|RGD=3820|UniProtKB=P04694	Tyrosine aminotransferase	ISS			PTHR11751:SF368	TYROSINE AMINOTRANSFERASE
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00025	Hedgehog signaling pathway	P00683	Slimb	RAT|RGD=1309121|UniProtKB=A0A0G2JVE0	Protein Fbxw11	ISS	12628165	PubMed	PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P00019	Endothelin signaling pathway	P00586	Gq	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	8838325	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00001	Adrenaline and noradrenaline biosynthesis	P00071	VAT1	HUMAN|HGNC=10934|UniProtKB=P54219	Chromaffin granule amine transporter	ISS	92370677	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00021	FGF signaling pathway	P00627	ERK1-2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00645	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00964	p90RSK	MONDO|Ensembl=ENSMODG00000008086|UniProtKB=F6YJ34	Ribosomal protein S6 kinase	ISS	2779569	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P04393	Ras Pathway	P04556	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	RCA			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00053	T cell activation	P01320	PLC-gamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00029	Huntington disease	P00777	CBP	ARATH|TAIR=AT3G12980|UniProtKB=Q9LE42	Histone acetyltransferase HAC5	IDA	10769018	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00005	Angiogenesis	P00221	JNK1	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MOUSE|MGI=MGI=95821|UniProtKB=Q01097	Glutamate receptor ionotropic, NMDA 2B	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT1G59580|UniProtKB=Q39022	Mitogen-activated protein kinase 2	ISS	10851062	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00018	EGF receptor signaling pathway	P00565	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IGI	8132661	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00018	EGF receptor signaling pathway	P00557	PI3K	ARATH|TAIR=AT1G60490|UniProtKB=P42339	Phosphatidylinositol 3-kinase VPS34	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00046	Oxidative stress response	P01135	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	SCHPO|PomBase=SPCC825.03c|UniProtKB=Q9USH7	Syntaxin-like protein psy1	IC			PTHR19957:SF41	SYNTAXIN-1A
P05731	GABA-B receptor II signaling	P05755	Gbeta	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P05731	GABA-B receptor II signaling	P05760	AC	RAT|RGD=71014|UniProtKB=Q04400	Adenylate cyclase type 5	RCA	93156838	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P02748	Isoleucine biosynthesis	P02998	Dihydroxyacid dehydratase	STRCO|Gene=CAB46389|UniProtKB=Q9X9Y4	Putative dihydroxy-acid dehydratase	ISS			PTHR43183:SF2	SUBFAMILY NOT NAMED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	XENTR|Xenbase=XB-GENE-493937|UniProtKB=Q5M8T9	Actin, alpha 2, smooth muscle, aorta	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	BOVIN|Ensembl=ENSBTAG00000005464|UniProtKB=E1B9K3	Uncharacterized protein	ISS	92357702	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00021	FGF signaling pathway	P00644	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	ISS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	RCA	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05918	p38 MAPK pathway	P06015	p38gamma	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	RCA	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	CAEEL|WormBase=WBGene00000108|UniProtKB=Q9TXM0	ALdehyde deHydrogenase	IC			PTHR11699:SF265	ALDEHYDE DEHYDROGENASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-478663|UniProtKB=F7EG64	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05915	Opioid proenkephalin pathway	P05987	peptide F	DANRE|ZFIN=ZDB-GENE-030729-31|UniProtKB=A8E7S2	Uncharacterized protein	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	8170357	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	HUMAN|HGNC=4215|UniProtKB=P55107	Growth/differentiation factor 10	TAS	9759503	PubMed	PTHR11848:SF145	GROWTH/DIFFERENTIATION FACTOR 10
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PLAF7|EnsemblGenome=PFL2215w|UniProtKB=Q8I4X0	Actin-1	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	MOUSE|MGI=MGI=97453|UniProtKB=P35454	Oxytocin-neurophysin 1	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02741	Flavin biosynthesis	P02936	FAD synthetase	RAT|RGD=1549748|UniProtKB=Q6AYA7	Protein Rfk	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000014577|UniProtKB=F7GRQ1	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF118	PROTOCADHERIN BETA-3
P00029	Huntington disease	P00780	Microtubule	IXOSC|EnsemblGenome=ISCW017136|UniProtKB=B7PA95	Beta tubulin	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	LEIMA|EnsemblGenome=LmjF.35.4010|UniProtKB=Q9GNR4	Protein kinase A catalytic subunit isoform 1	ISS	14744463	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00012	Cadherin signaling pathway	P00470	F-actin	RAT|RGD=1310826|UniProtKB=Q5M7U6	Actin-related protein 2	ISS	10974003	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00005	Angiogenesis	P00205	GAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	2574500	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00020	FAS signaling pathway	P00596	Caspase6	RAT|RGD=70967|UniProtKB=O35397	Caspase-6	ISS	10770929	PubMed	PTHR10454:SF164	CASPASE-6
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00029	Huntington disease	P00785	Cytochrome c	CAEEL|WormBase=WBGene00000869|UniProtKB=Q18853	CYtochrome C	IDA	15163634	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00053	T cell activation	P01319	PAK	MACMU|Ensembl=ENSMMUG00000001387|UniProtKB=F7D0B4	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=277|UniProtKB=P35348	Alpha-1A adrenergic receptor	IDA			PTHR24248:SF16	ALPHA-1A ADRENERGIC RECEPTOR
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00019	Endothelin signaling pathway	P00568	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	2837282	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MOUSE|MGI=MGI=87906|UniProtKB=P63260	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	HUMAN|HGNC=4593|UniProtKB=Q13255	Metabotropic glutamate receptor 1	IDA	7476890	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00036	Interleukin signaling pathway	P00970	Interleukin	PANTR|Ensembl=ENSPTRG00000017219|UniProtKB=P61126	Interleukin-13	ISS	8096327	PubMed	PTHR45413:SF1	INTERLEUKIN-13
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000025240|UniProtKB=F7A7I3	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	RAT|RGD=1594532|UniProtKB=Q4V8E2	Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14	ISS	9727008	PubMed	PTHR10410:SF5	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 14
P00005	Angiogenesis	P00223	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04546	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00046	Oxidative stress response	P01133	Max	HUMAN|HGNC=6913|UniProtKB=P61244	Protein max	TAS	11274345	PubMed	PTHR10328:SF3	PROTEIN MAX
P05730	Endogenous cannabinoid signaling	P05746	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IC	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	PANTR|Ensembl=ENSPTRG00000007489|UniProtKB=H2QA49	Tyrosine-protein kinase receptor	ISS	2877871	PubMed	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00539	14-3-3	CANLF|Ensembl=ENSCAFG00000013549|UniProtKB=E2QVP6	Uncharacterized protein	ISS	22165492	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00057	Wnt signaling pathway	P01435	SWI/SNF	ARATH|TAIR=AT3G12810|UniProtKB=Q7X9V2	Protein PHOTOPERIOD-INDEPENDENT EARLY FLOWERING 1	IDA	11532957	PubMed	PTHR10799:SF832	HELICASE DOMINO
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12701063	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05934	ELK1	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	3183861	gi	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	SCHPO|PomBase=SPBC32H8.07|UniProtKB=Q10282	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	MOUSE|MGI=MGI=109284|UniProtKB=Q61144	Presenilin-2	IDA	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04392	P53 pathway feedback loops 1	P04537	p73DeltaN	BOVIN|Ensembl=ENSBTAG00000015460|UniProtKB=F1MKA9	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00749	RGS9	BOVIN|Gene=RGS9|UniProtKB=O46469	Regulator of G-protein signaling 9	IDA	9459445	PubMed	PTHR10845:SF170	REGULATOR OF G-PROTEIN SIGNALING 9
P00005	Angiogenesis	P00199	JNKK1	PANTR|Ensembl=ENSPTRG00000008783|UniProtKB=H2QCA7	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00036	Interleukin signaling pathway	P00977	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P04393	Ras Pathway	P04569	Cdc42	TAKRU|Ensembl=ENSTRUG00000013411|UniProtKB=H2UB84	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	HUMAN|HGNC=1582|UniProtKB=P24385	G1/S-specific cyclin-D1	IEP	12356903	PubMed	PTHR10177:SF67	G1/S-SPECIFIC CYCLIN-D1
P00053	T cell activation	P01331	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IDA	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00046	Oxidative stress response	P01135	p38	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	TAS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00626	Spry	CANLF|Ensembl=ENSCAFG00000005260|UniProtKB=E2RGU9	Uncharacterized protein	ISS	12402043	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00046	Oxidative stress response	P01135	p38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	TAS	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	10553940	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00056	VEGF signaling pathway	P01417	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CHICK|Gene=CHRM4|UniProtKB=P17200	Muscarinic acetylcholine receptor M4	IDA	11166329	PubMed	PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00053	T cell activation	P01335	jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	IDA	8170357	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	188830	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000017387|UniProtKB=E2RLD1	Uncharacterized protein	ISS	129387	gi	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	RAT|RGD=1311608|UniProtKB=Q63801	Transcription initiation factor TFIID subunit 6	ISS			PTHR10221:SF12	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00019	Endothelin signaling pathway	P00587	Raf-1	CAEEL|WormBase=WBGene00003030|UniProtKB=Q07292	Raf homolog serine/threonine-protein kinase	ISS			PTHR44000:SF2	RAF HOMOLOG SERINE/THREONINE-PROTEIN KINASE PHL
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6879|UniProtKB=Q16659	Mitogen-activated protein kinase 6	ISS	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	MACMU|Ensembl=ENSMMUG00000000289|UniProtKB=F7A9T0	Uncharacterized protein	ISS	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000018511|UniProtKB=F7A8W3	Cadherin-8	ISS	8120095	PubMed	PTHR24027:SF273	CADHERIN-8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	HUMAN|HGNC=2211|UniProtKB=P12109	Collagen alpha-1(VI) chain	ISS	10727440	PubMed	PTHR44172:SF3	COLLAGEN ALPHA-1 VI  CHAIN
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BOVIN|Ensembl=ENSBTAG00000006495|UniProtKB=P11017	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00049	Parkinson disease	P01211	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00790	beta-Tubulin	PANTR|Ensembl=ENSPTRG00000023373|UniProtKB=G2HHT2	Tubulin beta-2C chain	ISS	9454836	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	XENTR|Xenbase=XB-GENE-490883|UniProtKB=Q6NVA9	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00580	ET-RA/B	MACMU|Ensembl=ENSMMUG00000003659|UniProtKB=F7HSF3	Endothelin-1 receptor isoform a	ISS	91195317	PubMed	PTHR24243:SF31	ENDOTHELIN-1 RECEPTOR
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	PANTR|Ensembl=ENSPTRG00000006510|UniProtKB=H2Q8K1	Presenilin	ISS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00005	Angiogenesis	P00231	HSP27	CIOIN|Ensembl=ENSCING00000000618|UniProtKB=F6RRK4	Uncharacterized protein	ISS			PTHR11527:SF243	SUBFAMILY NOT NAMED
P00012	Cadherin signaling pathway	P00468	Src	PANTR|Ensembl=ENSPTRG00000013474|UniProtKB=H2QKB4	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00006	Apoptosis signaling pathway	P00314	MKK3	RAT|RGD=1306620|UniProtKB=B1H230	Map2k3 protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=708420|UniProtKB=Q62688	Inactive phospholipase C-like protein 1	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00029	Huntington disease	P00786	ARF	ARATH|TAIR=AT1G02430|UniProtKB=F4HXI4	ADP-ribosylation factor D1B	IPI	12932731	PubMed	PTHR11711:SF210	ADP-RIBOSYLATION FACTOR 2-A-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	BOVIN|Ensembl=ENSBTAG00000011209|UniProtKB=A6H7H8	SYT11 protein	ISS			PTHR10024:SF115	SYNAPTOTAGMIN-11
P00036	Interleukin signaling pathway	P00975	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	88318957	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00019	Endothelin signaling pathway	P00567	PKG	ANOGA|Gene=AgaP_AGAP008863|UniProtKB=Q7PWT0	AGAP008863-PA	ISS			PTHR24353:SF108	SUBFAMILY NOT NAMED
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	PANTR|Ensembl=ENSPTRG00000006216|UniProtKB=H2Q832	Adenylate cyclase 4	ISS	1946437	PubMed	PTHR11920:SF286	ADENYLATE CYCLASE TYPE 4
P00059	p53 pathway	P04633	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	MONDO|Ensembl=ENSMODG00000003969|UniProtKB=F7FMF5	Uncharacterized protein	ISS			PTHR10937:SF10	GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE  ISOMERIZING  2
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	PYRAE|EnsemblGenome=PAE3025|UniProtKB=Q8ZTZ0	Glutamine--fructose-6-phosphate aminotransferase [isomerizing]	ISS			PTHR10937:SF0	GH12731P-RELATED
P00021	FGF signaling pathway	P00638	PLCgamma	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00054	Toll receptor signaling pathway	P01375	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00018	EGF receptor signaling pathway	P00564	Rac	ORYSJ|Gene=Os01g0229400|UniProtKB=Q9SSX0	Rac-like GTP-binding protein 1	IGI	99415960	PubMed	PTHR24072:SF154	SUBFAMILY NOT NAMED
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00005	Angiogenesis	P00204	PLD	CAEBR|Gene=CBG02320|UniProtKB=A8WUL4	Protein CBR-PLD-1	ISS			PTHR18896:SF76	PHOSPHOLIPASE D2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01205	NOS	BOVIN|Gene=NOS3|UniProtKB=P29473	Nitric oxide synthase, endothelial	ISS	93055452	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	MACMU|Ensembl=ENSMMUG00000021075|UniProtKB=F7GY91	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00049	Parkinson disease	P01234	GRK	CAEEL|WormBase=WBGene00001709|UniProtKB=Q09639	G protein-coupled receptor kinase 2	IDA	8260489	PubMed	PTHR24355:SF18	PROTEIN-SERINE/THREONINE KINASE
P00006	Apoptosis signaling pathway	P00269	MAPK	ORYSJ|EnsemblGenome=OS06G0154500|UniProtKB=Q84UI5	Mitogen-activated protein kinase 1	ISS	12787066	PubMed	PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00047	PDGF signaling pathway	P01168	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	IC	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	RAT|RGD=69319|UniProtKB=P54313	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00047	PDGF signaling pathway	P01155	Jak	MOUSE|MGI=MGI=96628|UniProtKB=P52332	Tyrosine-protein kinase JAK1	ISS	11929133	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P04393	Ras Pathway	P04546	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00047	PDGF signaling pathway	P01174	Rho	RAT|RGD=1310017|UniProtKB=A0A0G2K1Z2	Protein Arhgap12	ISS			PTHR23181:SF3	RHO GTPASE-ACTIVATING PROTEIN 12
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00048	PI3 kinase pathway	P01185	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000012036|UniProtKB=F7ALP1	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	HUMAN|HGNC=1736|UniProtKB=P60953	Cell division control protein 42 homolog	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	XENTR|Xenbase=XB-GENE-961282|UniProtKB=Q6DF43	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IC	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00018	EGF receptor signaling pathway	P00560	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01242	Casein kinase I	MACMU|Ensembl=ENSMMUG00000005012|UniProtKB=F7AM42	Casein kinase I isoform alpha-like protein	ISS	11437445	PubMed	PTHR11909:SF139	CASEIN KINASE I ISOFORM ALPHA-LIKE
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	MONDO|Ensembl=ENSMODG00000011192|UniProtKB=F6SRK5	Uncharacterized protein	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00833	RGS	MOUSE|MGI=MGI=1927498|UniProtKB=Q99PG4	Regulator of G-protein signaling 18	IDA	8756726	PubMed	PTHR10845:SF155	REGULATOR OF G-PROTEIN SIGNALING 18
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	MACMU|Ensembl=ENSMMUG00000010173|UniProtKB=F7AGU8	Presenilin	ISS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04398	p53 pathway feedback loops 2	P04665	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01428	Frizzled	XENTR|Xenbase=XB-GENE-478210|UniProtKB=F6V5F4	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF23	FRIZZLED-4
P06664	Gonadotropin-releasing hormone receptor pathway	P06812	L-type Ca2+	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	RCA	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00025	Hedgehog signaling pathway	P00682	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01423	p38MAPK	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02765	Phenylalanine biosynthesis	P03099	Prephenate dehydratase	ARATH|TAIR=AT3G44720|UniProtKB=O22241	Arogenate dehydratase 4, chloroplastic	ISS			PTHR21022:SF14	AROGENATE DEHYDRATASE 3, CHLOROPLASTIC-RELATED
P05734	Synaptic vesicle trafficking	P05774	NSF	CHICK|Ensembl=ENSGALG00000001055|UniProtKB=E1BQU4	Uncharacterized protein	ISS	601633	OMIM	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000002948|UniProtKB=H2RC26	Uncharacterized protein	ISS	10908612	PubMed	PTHR21230:SF39	VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	PSEAE|EnsemblGenome=PA4519|UniProtKB=Q9HVQ3	Ornithine decarboxylase	ISS			PTHR11482:SF6	ORNITHINE DECARBOXYLASE 1-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	XENTR|Xenbase=XB-GENE-961764|UniProtKB=F6W3Y0	Uncharacterized protein	ISS	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	PANTR|Ensembl=ENSPTRG00000002149|UniProtKB=H2R0U9	Uncharacterized protein	ISS	15858232	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	RAT|RGD=621533|UniProtKB=P12389	Neuronal acetylcholine receptor subunit alpha-2	ISS	85270494	PubMed	PTHR18945:SF757	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-2
P00047	PDGF signaling pathway	P01143	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02779	Thiamin biosynthesis	P03175	1-Deoxyxylulose-5-phosphate synthase	AQUAE|EnsemblGenome=aq_881|UniProtKB=O67036	1-deoxy-D-xylulose-5-phosphate synthase	ISS			PTHR43322:SF6	1-DEOXY-D-XYLULOSE-5-PHOSPHATE SYNTHASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_188187|UniProtKB=E9GJ31	Guanine nucleotide binding protein, q polypeptide	ISS	8836152	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00029	Huntington disease	P00796	Kainate receptor	CHICK|Ensembl=ENSGALG00000015434|UniProtKB=F1NU20	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00034	Integrin signalling pathway	P00925	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	EMENI|EnsemblGenome=CADANIAG00007315|UniProtKB=P20359	Actin, gamma	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00990	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05962	DAT	MACMU|Ensembl=ENSMMUG00000005198|UniProtKB=Q7JHP9	Transporter	ISS	92107910	PubMed	PTHR11616:SF38	SODIUM-DEPENDENT DOPAMINE TRANSPORTER
P04398	p53 pathway feedback loops 2	G04714	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00053	T cell activation	P01332	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00965	ERK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CAEBR|Gene=CBG05858|UniProtKB=A8X1H0	Protein CBR-EGL-19 (Fragment)	ISS	91056091	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00021	FGF signaling pathway	P00624	14-3-3	DANRE|ZFIN=ZDB-GENE-061023-2|UniProtKB=E7F354	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00053	T cell activation	P01330	IKK	PANTR|Ensembl=ENSPTRG00000020202|UniProtKB=H2QW34	Uncharacterized protein	ISS	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00053	T cell activation	P01310	Lck	HUMAN|HGNC=6524|UniProtKB=P06239	Tyrosine-protein kinase Lck	IGI	11078745	PubMed	PTHR24418:SF39	TYROSINE-PROTEIN KINASE LCK
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00627	ERK1-2	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00034	Integrin signalling pathway	P00912	Arp2/3	MONDO|Ensembl=ENSMODG00000007194|UniProtKB=F6X9N6	Actin-related protein 2/3 complex subunit 5	ISS	9230079	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P04393	Ras Pathway	P04572	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00013	Cell cycle	P00484	Cyclin D	STRPU|EnsemblGenome=SPU_007013|UniProtKB=Q964G0	Cyclin D	IEP	22048059	PubMed	PTHR10177:SF246	CYCLIN D, ISOFORM D
P00020	FAS signaling pathway	P00610	MKK4	CHICK|Ensembl=ENSGALG00000001001|UniProtKB=F1P3T1	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00036	Interleukin signaling pathway	P00965	ERK	BOVIN|Ensembl=ENSBTAG00000005865|UniProtKB=G5E577	Uncharacterized protein	ISS	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00029	Huntington disease	P00790	beta-Tubulin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g245773|UniProtKB=A7SJX9	Predicted protein	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CAEBR|Gene=CBG18256|UniProtKB=A8XS95	Protein CBR-ACT-5	ISS	14684598	PubMed	PTHR11937:SF352	ACTIN
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00269	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00004	Alzheimer disease-presenilin pathway	P00131	HAC1	RAT|RGD=70074|UniProtKB=O70277	Tripartite motif-containing protein 3	IDA			PTHR44028:SF1	TRIPARTITE MOTIF-CONTAINING PROTEIN 3
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IDA	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00025	Hedgehog signaling pathway	P00683	Slimb	BOVIN|Ensembl=ENSBTAG00000007476|UniProtKB=F1MVN1	Uncharacterized protein	ISS	10074433	PubMed	PTHR44038:SF2	F-BOX/WD REPEAT-CONTAINING PROTEIN 1A
P02749	Leucine biosynthesis	P03000	Branched chain amino acid aminotransferase	BOVIN|Ensembl=ENSBTAG00000013825|UniProtKB=A4IFQ7	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF51	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, CYTOSOLIC
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000022000|UniProtKB=Q9MZL5	Voltage-dependent L-type calcium channel subunit beta-2	IC	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00034	Integrin signalling pathway	P00944	Actin	MONDO|Ensembl=ENSMODG00000025240|UniProtKB=F7A7I3	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	IDA	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	MACMU|Ensembl=ENSMMUG00000000163|UniProtKB=F7HLV0	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF82	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-6
P00048	PI3 kinase pathway	P01199	Galpha	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	IC			PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	ANOGA|EnsemblGenome=AGAP005912|UniProtKB=Q7Q6D3	AGAP005912-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	NEUCR|EnsemblGenome=EFNCRG00000000159|UniProtKB=F5HH30	Guanine nucleotide-binding protein beta subunit	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	TAS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P02728	Arginine biosynthesis	P02842	N-acetylornithine aminotransferase	YEAST|SGD=S000005500|UniProtKB=P18544	Acetylornithine aminotransferase, mitochondrial	ISS	10074354	PubMed	PTHR11986:SF79	ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL
P05913	Enkephalin release	P05976	Enkephalin	HUMAN|HGNC=8831|UniProtKB=P01210	Proenkephalin-A	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00056	VEGF signaling pathway	P01411	Ras	MONDO|Gene=KRAS|UniProtKB=Q07983	GTPase KRas	ISS	9869449	PubMed	PTHR24070:SF186	GTPASE KRAS
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	8787761	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00790	beta-Tubulin	EMENI|EnsemblGenome=CADANIAG00007636|UniProtKB=P10874	Tubulin beta-2 chain	TAS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00030	Hypoxia response via HIF activation	P00824	PTEN	ARATH|TAIR=AT3G19420|UniProtKB=Q9LT75	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN2A	ISS			PTHR12305:SF32	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE TPTE2-RELATED
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=107433|UniProtKB=P70407	Cadherin-9	ISS	8120095	PubMed	PTHR24027:SF99	CADHERIN-9
P04393	Ras Pathway	P04572	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00056	VEGF signaling pathway	P01408	Akt/PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01421	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	RCA			PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00005	Angiogenesis	P00217	STAT3	CANLF|Ensembl=ENSCAFG00000015213|UniProtKB=E2RB82	Signal transducer and activator of transcription	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00018	EGF receptor signaling pathway	P00542	EGFR	CHICK|Ensembl=ENSGALG00000003126|UniProtKB=F1P258	Receptor protein-tyrosine kinase	ISS	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	7565716	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00059	p53 pathway	P04626	GADD45	MOUSE|MGI=MGI=107799|UniProtKB=P48316	Growth arrest and DNA damage-inducible protein GADD45 alpha	IDA	7509226	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P06959	CCKR signaling map	P07215	G17	HUMAN|HGNC=4164|UniProtKB=P01350	Gastrin	RCA	9074765	PubMed	PTHR19309:SF0	GASTRIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01070	K+ channel	MOUSE|MGI=MGI=1309503|UniProtKB=Q9Z351	Potassium voltage-gated channel subfamily KQT member 2	ISS	12165472	PubMed	PTHR11537:SF6	POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 2
P00029	Huntington disease	P00796	Kainate receptor	PANTR|Ensembl=ENSPTRG00000013825|UniProtKB=H2RAK4	Uncharacterized protein	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00034	Integrin signalling pathway	P00924	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IPI	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00053	T cell activation	P01332	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00012	Cadherin signaling pathway	P00470	F-actin	PUCGT|EnsemblGenome=PGTG_05488|UniProtKB=E3K4I1	Actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	RAT|RGD=1586637|UniProtKB=F1LMY4	Ryanodine receptor 1	ISS	15858232	PubMed	PTHR13715:SF15	RYANODINE RECEPTOR 1
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	CANLF|Ensembl=ENSCAFG00000018564|UniProtKB=E2RHU1	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	MOUSE|MGI=MGI=1933206|UniProtKB=A2AIR5	Protein Grin3a	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P04393	Ras Pathway	P04568	MKK3/6	BOVIN|Ensembl=ENSBTAG00000010576|UniProtKB=A4IFH7	MAP2K3 protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04393	Ras Pathway	P04553	PAK	CANLF|Ensembl=ENSCAFG00000004956|UniProtKB=E2REH3	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P05915	Opioid proenkephalin pathway	P05987	peptide F	MOUSE|MGI=MGI=104629|UniProtKB=P22005	Proenkephalin-A	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00034	Integrin signalling pathway	P00920	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00048	PI3 kinase pathway	P01177	P110ACT	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00931	Integrin beta	CANLF|Ensembl=ENSCAFG00000013735|UniProtKB=F1PPG5	Integrin beta	IDA	20069419	gi	PTHR10082:SF25	INTEGRIN BETA-3
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	21186066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00632	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	20855874	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	ORNAN|Ensembl=ENSOANG00000006119|UniProtKB=F6WTY3	Uncharacterized protein	ISS	12374786	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00023	General transcription regulation	P00662	TFIIA complex	MOUSE|MGI=MGI=1933289|UniProtKB=Q80ZM7	Transcription initiation factor IIA subunit 2	ISS			PTHR10966:SF0	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2
P00019	Endothelin signaling pathway	P00581	Guanylate cyclase	PANTR|Ensembl=ENSPTRG00000004238|UniProtKB=H2Q4P3	Uncharacterized protein	RCA			PTHR11920:SF276	GUANYLATE CYCLASE SOLUBLE SUBUNIT ALPHA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00021	FGF signaling pathway	P00643	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000005792|UniProtKB=F6VTR8	Uncharacterized protein	ISS	12507995	PubMed	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00029	Huntington disease	P00807	Actin	HUMAN|HGNC=129|UniProtKB=P68133	Actin, alpha skeletal muscle	IDA	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P05730	Endogenous cannabinoid signaling	P05751	Galpha	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	RCA	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04393	Ras Pathway	P04572	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000008269|UniProtKB=H2QBE4	Cadherin 3, type 1, P-cadherin (Placental)	ISS	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P02769	Purine metabolism	P03115	Nucleoside Phosphorylase	MOUSE|MGI=MGI=97365|UniProtKB=P23492	Purine nucleoside phosphorylase	ISS	7903568	PubMed	PTHR11904:SF12	PURINE NUCLEOSIDE PHOSPHORYLASE
P00010	B cell activation	P00379	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IDA	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	HUMAN|HGNC=4573|UniProtKB=P42263	Glutamate receptor 3	ISS	12871085	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P02778	Sulfate assimilation	P03167	Sulfate adenylyltransferase	ARATH|TAIR=AT1G19920|UniProtKB=Q43870	ATP sulfurylase 2	ISS			PTHR11055:SF18	ATP SULFURYLASE 1, CHLOROPLASTIC-RELATED
P02738	De novo purine biosynthesis	P02891	GDP kinase	HUMAN|HGNC=7851|UniProtKB=Q13232	Nucleoside diphosphate kinase 3	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P00006	Apoptosis signaling pathway	P00269	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00545	JNK1-3	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CAEEL|WormBase=WBGene00004045|UniProtKB=Q8IA75	Phosphoinositide phospholipase C	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	RAT|RGD=3563|UniProtKB=P49807	Regulator of G-protein signaling 11 (Fragment)	ISS	8756726	PubMed	PTHR10845:SF144	REGULATOR OF G-PROTEIN SIGNALING 11
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	HUMAN|HGNC=6698|UniProtKB=O75581	Low-density lipoprotein receptor-related protein 6	IDA	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	METJA|EnsemblGenome=MJ_1019|UniProtKB=Q58425	Carbamoyl-phosphate synthase small chain	ISS			PTHR11405:SF4	CARBAMOYL-PHOSPHATE SYNTHASE ARGININE-SPECIFIC SMALL CHAIN
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MOUSE|MGI=MGI=87909|UniProtKB=P62737	Actin, aortic smooth muscle	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	8838325	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	RAT|RGD=68384|UniProtKB=P39948	G1/S-specific cyclin-D1	IEP	12356903	PubMed	PTHR10177:SF67	G1/S-SPECIFIC CYCLIN-D1
P00057	Wnt signaling pathway	P01471	alpha-catenin	MOUSE|MGI=MGI=2661445|UniProtKB=Q65CL1	Catenin alpha-3	ISS	9362521	PubMed	PTHR18914:SF21	CATENIN ALPHA-3
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00001	Adrenaline and noradrenaline biosynthesis	P00067	MAO	HUMAN|HGNC=6834|UniProtKB=P27338	Amine oxidase [flavin-containing] B	ISS	8602220	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	MONDO|Ensembl=ENSMODG00000015456|UniProtKB=F6S406	Uncharacterized protein	ISS	9362521	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P00053	T cell activation	P01317	CD3 gamma	MOUSE|MGI=MGI=88333|UniProtKB=P11942	T-cell surface glycoprotein CD3 gamma chain	IGI	9886373	PubMed	PTHR10570:SF8	T-CELL SURFACE GLYCOPROTEIN CD3 GAMMA CHAIN
P00021	FGF signaling pathway	P00648	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IDA	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	IDA	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	RAT|RGD=2739|UniProtKB=Q00961	Glutamate receptor ionotropic, NMDA 2C	ISS	11554549	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00034	Integrin signalling pathway	P00925	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IDA	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00004	Alzheimer disease-presenilin pathway	P00117	E-cadherin C-terminal fragment	MOUSE|MGI=MGI=88356|UniProtKB=P10287	Cadherin-3	IDA	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	ARATH|TAIR=AT1G75780|UniProtKB=P12411	Tubulin beta-1 chain	ISS	12932731	PubMed	PTHR11588:SF116	TUBULIN BETA-1 CHAIN-RELATED
P00018	EGF receptor signaling pathway	P00551	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00318	PKCs	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MOUSE|MGI=MGI=95822|UniProtKB=Q01098	Glutamate receptor ionotropic, NMDA 2C	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00021	FGF signaling pathway	P00644	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00056	VEGF signaling pathway	P01413	PI3K	XENTR|Xenbase=XB-GENE-6067221|UniProtKB=F6Z0J4	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P05918	p38 MAPK pathway	P06018	MNK1	RAT|RGD=1559603|UniProtKB=Q4G050	MAP kinase-interacting serine/threonine-protein kinase 1	ISS	9155018	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00995	c-Myc	BOVIN|Ensembl=ENSBTAG00000008409|UniProtKB=Q2HJ27	Myc proto-oncogene protein	ISS	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	RCA	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000011757|UniProtKB=Q9XT97	Presenilin-1	TAS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00049	Parkinson disease	P01211	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00012	Cadherin signaling pathway	P00470	F-actin	XENTR|Xenbase=XB-GENE-491938|UniProtKB=Q6DIV8	Actin, alpha 1, skeletal muscle	ISS	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P04393	Ras Pathway	P04570	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01407	Erk	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TRIAD|EnsemblGenome=TriadG49626|UniProtKB=B3RKR4	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	ISS	1319556	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00019	Endothelin signaling pathway	P00566	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00648	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00048	PI3 kinase pathway	P01187	IR	RAT|RGD=2917|UniProtKB=P15127	Insulin receptor	IDA	6754360	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00021	FGF signaling pathway	P00628	JNK1-3	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	ISS			PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00006	Apoptosis signaling pathway	P00318	PKCs	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04398	p53 pathway feedback loops 2	G04714	PTEN	DROME|FlyBase=FBgn0026379|UniProtKB=Q7KMQ6	IP16020p	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00005	Angiogenesis	P00203	Erk	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05915	Opioid proenkephalin pathway	P05988	peptide E	RAT|RGD=68946|UniProtKB=P04094	Proenkephalin-A	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04578	Rho	RAT|RGD=1304965|UniProtKB=A0A0G2K6E0	Protein Rhoc	ISS	14871999	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	CHICK|Gene=COL6A3|UniProtKB=P15989	Collagen alpha-3(VI) chain	IC	10778855	PubMed	PTHR44105:SF2	COLLAGEN ALPHA-3 VI  CHAIN
P00056	VEGF signaling pathway	P01408	Akt/PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00279	endoG	MACMU|Ensembl=ENSMMUG00000003294|UniProtKB=F7FG25	Uncharacterized protein	ISS			PTHR13966:SF5	ENDONUCLEASE G, MITOCHONDRIAL
P00018	EGF receptor signaling pathway	P00545	JNK1-3	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00029	Huntington disease	P00786	ARF	PANTR|Ensembl=ENSPTRG00000002066|UniProtKB=G2HIU2	ADP-ribosylation factor 1	ISS	12932731	PubMed	PTHR11711:SF234	ADP-RIBOSYLATION FACTOR 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00029	Huntington disease	P00780	Microtubule	RAT|RGD=628596|UniProtKB=P69897	Tubulin beta-5 chain	ISS	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00007	Axon guidance mediated by semaphorins	P00341	Rho	XENTR|Xenbase=XB-GENE-489222|UniProtKB=Q28GJ8	Ras homolog gene family, member A	ISS	10556059	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00048	PI3 kinase pathway	P01196	PDK1	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	IDA	11256888	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00385	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	MONDO|Ensembl=ENSMODG00000005927|UniProtKB=F6WX28	Uncharacterized protein	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00056	VEGF signaling pathway	P01421	Rac	CANLF|Ensembl=ENSCAFG00000009147|UniProtKB=A4GT58	Cdc42 GTPase-activating protein	ISS			PTHR23176:SF28	RHO GTPASE-ACTIVATING PROTEIN 1
P00034	Integrin signalling pathway	P00916	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IPI	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P00019	Endothelin signaling pathway	P00566	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00052	TGF-beta signaling pathway	P01286	TGFbeta	PANTR|Ensembl=ENSPTRG00000005132|UniProtKB=H2Q6B2	Inhibin, beta E	ISS	9759503	PubMed	PTHR11848:SF6	INHIBIN BETA E CHAIN
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01188	Gbetagamma	NEUCR|EnsemblGenome=EFNCRG00000000159|UniProtKB=F5HH30	Guanine nucleotide-binding protein beta subunit	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00015	Circadian clock system	G01499	per	MOUSE|MGI=MGI=1277134|UniProtKB=O70361	Period circadian protein homolog 3	ISS	98372739	PubMed	PTHR11269:SF13	PERIOD CIRCADIAN PROTEIN HOMOLOG 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MONDO|Ensembl=ENSMODG00000012546|UniProtKB=F6PM16	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	RAT|RGD=3876|UniProtKB=P16599	Tumor necrosis factor	ISS	8879212	PubMed	PTHR11471:SF23	TUMOR NECROSIS FACTOR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	BOVIN|Ensembl=ENSBTAG00000016629|UniProtKB=E1BM79	Adenylyl CYclase family member (Acy-1)-like	ISS	2491850	PubMed	PTHR11920:SF319	ADENYLATE CYCLASE TYPE 9
P00023	General transcription regulation	P00666	TFIIE	PANTR|Ensembl=ENSPTRG00000015273|UniProtKB=H2QN66	General transcription factor IIE, polypeptide 1, alpha 56kDa	ISS	189964	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00037	Ionotropic glutamate receptor pathway	P01023	CaMKII	HUMAN|HGNC=1460|UniProtKB=Q9UQM7	Calcium/calmodulin-dependent protein kinase type II subunit alpha	ISS	12888804	PubMed	PTHR43940:SF5	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	XENTR|Xenbase=XB-GENE-961282|UniProtKB=Q6DF43	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00047	PDGF signaling pathway	P01162	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00024	Glycolysis	P00678	Enolase	PANTR|Ensembl=ENSPTRG00000000109|UniProtKB=G2HFA5	Alpha-enolase	ISS	99439677	PubMed	PTHR11902:SF12	ALPHA-ENOLASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	RAT|RGD=628837|UniProtKB=P60711	Actin, cytoplasmic 1	IC	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MOUSE|MGI=MGI=95389|UniProtKB=P09065	Homeobox protein engrailed-1	IEP	12356903	PubMed	PTHR24341:SF4	HOMEOBOX PROTEIN ENGRAILED-1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00114	actin	TRIAD|EnsemblGenome=TriadG35956|UniProtKB=Q7YTV5	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04397	p53 pathway by glucose deprivation	P04640	p53	CANLF|Ensembl=ENSCAFG00000013961|UniProtKB=F1PL57	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00052	TGF-beta signaling pathway	P01286	TGFbeta	BOVIN|Ensembl=ENSBTAG00000007417|UniProtKB=F1MXM6	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF166	GROWTH/DIFFERENTIATION FACTOR 11
P00060	Ubiquitin proteasome pathway	P01491	E2	RAT|RGD=727838|UniProtKB=Q7M767	Ubiquitin-conjugating enzyme E2 variant 2	ISS			PTHR43915:SF3	UBIQUITIN-CONJUGATING ENZYME E2 VARIANT 2
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01455	Smad4	DANRE|ZFIN=ZDB-GENE-991119-8|UniProtKB=Q9I8V2	Mothers against decapentaplegic homolog 1	IDA	12736218	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P04393	Ras Pathway	P04552	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00015	Circadian clock system	P00505	Cry	CHICK|Gene=CRY2|UniProtKB=Q8QG60	Cryptochrome-2	ISS			PTHR11455:SF15	CRYPTOCHROME-2
P00057	Wnt signaling pathway	P01437	TCF	MACMU|Ensembl=ENSMMUG00000023256|UniProtKB=F7HPX5	Uncharacterized protein	ISS	11266476	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00047	PDGF signaling pathway	P01157	MAPKAPK2	PANTR|Ensembl=ENSPTRG00000001915|UniProtKB=H2Q104	Mitogen-activated protein kinase-activated protein kinase 2	ISS	10779545	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00056	VEGF signaling pathway	P01414	PLC-gamma	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00021	FGF signaling pathway	P00629	PP2A	SCHPO|PomBase=SPAC6F12.12|UniProtKB=P78759	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta 2 isoform	ISS	10092233	PubMed	PTHR10257:SF3	PP2A-B', ISOFORM B
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	CHICK|Ensembl=ENSGALG00000008459|UniProtKB=F6RIN4	Receptor protein serine/threonine kinase	TAS	9395284	PubMed	PTHR23255:SF63	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MONDO|Ensembl=ENSMODG00000000771|UniProtKB=F6SSS3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00034	Integrin signalling pathway	P00914	Filamin	HUMAN|HGNC=3754|UniProtKB=P21333	Filamin-A	IPI	9722563	PubMed	PTHR43998:SF6	FILAMIN-A
P04398	p53 pathway feedback loops 2	P04665	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	MOUSE|MGI=MGI=1202879|UniProtKB=Q924A0	Transcription factor 7-like 2	TAS	9118222	PubMed	PTHR10373:SF32	TRANSCRIPTION FACTOR 7-LIKE 2
P00010	B cell activation	P00383	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CAEEL|WormBase=WBGene00001664|UniProtKB=P22454	Guanine nucleotide-binding protein alpha-2 subunit	ISS	12488551	PubMed	PTHR10218:SF245	GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-2 SUBUNIT-RELATED
P04393	Ras Pathway	P04558	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00053	T cell activation	P01300	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	9298898	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	TAS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00126	Fe65	CANLF|Ensembl=ENSCAFG00000006420|UniProtKB=E2QWV4	Uncharacterized protein	ISS	15115822	PubMed	PTHR14058:SF5	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1
P00036	Interleukin signaling pathway	P00983	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00009	Axon guidance mediated by netrin	P00363	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	14526383	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01084	CHT1	CANLF|Ensembl=ENSCAFG00000002064|UniProtKB=E2RAJ0	Uncharacterized protein	RCA			PTHR11819:SF129	HIGH AFFINITY CHOLINE TRANSPORTER 1
P00021	FGF signaling pathway	P00627	ERK1-2	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	IGI	10851062	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	BOVIN|Ensembl=ENSBTAG00000003054|UniProtKB=F1MC23	Tyrosine-protein kinase receptor	ISS	11182407	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00059	p53 pathway	P04633	P110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00046	Oxidative stress response	P01129	JNK1/2	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	IC	88234494	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01352	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	ISS	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00037	Ionotropic glutamate receptor pathway	P01001	KA4	PANTR|Gene=GRIK4|UniProtKB=Q5IS46	Glutamate receptor ionotropic, kainate 4	ISS	11319238	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	PANTR|Ensembl=ENSPTRG00000014576|UniProtKB=H2QLZ9	Uncharacterized protein	ISS	11431030	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00054	Toll receptor signaling pathway	P01346	TLR	STRPU|EnsemblGenome=SPU_014266|UniProtKB=W4YET5	Uncharacterized protein	ISS			PTHR24368:SF210	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000009389|UniProtKB=F7HEV7	Uncharacterized protein	ISS	11259487	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00034	Integrin signalling pathway	P00920	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IDA	98189216	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00057	Wnt signaling pathway	P01454	betaTrCP	MONDO|Ensembl=ENSMODG00000006464|UniProtKB=F7FGS3	Uncharacterized protein	ISS	10074433	PubMed	PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	CANLF|Ensembl=ENSCAFG00000018564|UniProtKB=E2RHU1	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	TAS	14526383	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00790	beta-Tubulin	ORNAN|Ensembl=ENSOANG00000004797|UniProtKB=F7FFR0	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P00059	p53 pathway	P04633	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00561	STAT	CANLF|Ensembl=ENSCAFG00000015346|UniProtKB=E2RE22	Signal transducer and activator of transcription	ISS	8584036	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00010	B cell activation	P00371	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01457	GBeta	NEUCR|EnsemblGenome=EFNCRG00000000159|UniProtKB=F5HH30	Guanine nucleotide-binding protein beta subunit	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00036	Interleukin signaling pathway	P00970	Interleukin	MOUSE|MGI=MGI=107936|UniProtKB=P70380	Interleukin-18	IDA	22329004	PubMed	PTHR45200:SF1	INTERLEUKIN-18
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	MONDO|Ensembl=ENSMODG00000000981|UniProtKB=F7ES59	Uncharacterized protein	ISS	12090470	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P02728	Arginine biosynthesis	P02840	Argininosuccinate synthase	CANLF|Ensembl=ENSCAFG00000019945|UniProtKB=E2QU08	Uncharacterized protein	ISS			PTHR11587:SF2	ARGININOSUCCINATE SYNTHASE
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IGI	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00057	Wnt signaling pathway	P01465	Ggamma	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00010	B cell activation	P00373	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IGI	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00049	Parkinson disease	P01211	ERK	MACMU|Ensembl=ENSMMUG00000008536|UniProtKB=F6WBZ5	Mitogen-activated protein kinase	ISS	12912994	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00019	Endothelin signaling pathway	P00586	Gq	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05913	Enkephalin release	P05974	G-Protein (i)	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00586	Gq	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00047	PDGF signaling pathway	P01162	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00019	Endothelin signaling pathway	P00566	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00641	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00021	FGF signaling pathway	P00627	ERK1-2	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00056	VEGF signaling pathway	P01414	PLC-gamma	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P05915	Opioid proenkephalin pathway	P05985	Mu or Delta receptor	HUMAN|HGNC=8153|UniProtKB=P41143	Delta-type opioid receptor	RCA	11259498	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00005	Angiogenesis	P00237	FRP	MONDO|Ensembl=ENSMODG00000008701|UniProtKB=F6PWM3	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF22	FRIZZLED-3
P00018	EGF receptor signaling pathway	P00543	ERK1-2	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00927	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	IGI	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P02772	Pyruvate metabolism	P03139	Lactate Dehydrogenase	PLAF7|EnsemblGenome=PF13_0141|UniProtKB=Q76NM3	L-lactate dehydrogenase	TAS	8901865	PubMed	PTHR11540:SF16	MALATE DEHYDROGENASE, MITOCHONDRIAL
P00018	EGF receptor signaling pathway	P00564	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00036	Interleukin signaling pathway	P00965	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05730	Endogenous cannabinoid signaling	P05751	Galpha	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00011	Blood coagulation	P00410	GP IIb	HUMAN|HGNC=6138|UniProtKB=P08514	Integrin alpha-IIb	ISS	3487386	PubMed	PTHR23220:SF73	INTEGRIN ALPHA-IIB
P00036	Interleukin signaling pathway	P00968	Ikk	RAT|RGD=621375|UniProtKB=Q9QY78	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00010	B cell activation	P00373	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IGI	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=5287|UniProtKB=P28222	5-hydroxytryptamine receptor 1B	IDA	12441358	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P00011	Blood coagulation	P00408	Plasminogen	MOUSE|MGI=MGI=97620|UniProtKB=P20918	Plasminogen	ISS	16758216	gi	PTHR24261:SF5	PLASMINOGEN
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	HUMAN|HGNC=130|UniProtKB=P62736	Actin, aortic smooth muscle	IEP	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	MOUSE|MGI=MGI=1321161|UniProtKB=P62715	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	SCHPO|PomBase=SPCC1259.06|UniProtKB=O94706	Transcription initiation factor TFIID subunit 8	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00036	Interleukin signaling pathway	P00979	MAPKAPK2	BOVIN|Ensembl=ENSBTAG00000038107|UniProtKB=F1MCX5	Uncharacterized protein	ISS	9628873	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00030	Hypoxia response via HIF activation	P00823	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01211	ERK	MACMU|Ensembl=ENSMMUG00000008536|UniProtKB=F6WBZ5	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00021	FGF signaling pathway	P00630	RKIP	DICDI|dictyBase=DDB_G0275583|UniProtKB=Q86H88	Uncharacterized protein	ISS			PTHR11362:SF72	SUBFAMILY NOT NAMED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01446	Calcineurin	CRYNJ|EnsemblGenome=CNJ02230|UniProtKB=Q5KAC2	Serine/threonine-protein phosphatase	ISS	12015605	PubMed	PTHR11668:SF118	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00059	p53 pathway	G04692	R2	CANLF|Ensembl=ENSCAFG00000003409|UniProtKB=E2R7H9	Uncharacterized protein	ISS			PTHR23409:SF20	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00053	T cell activation	P01318	PKC-theta	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P02738	De novo purine biosynthesis	P02902	ADP reductase	MYCTU|EnsemblGenome=Rv1981c|UniProtKB=P9WH73	Ribonucleoside-diphosphate reductase subunit beta nrdF1	ISS			PTHR23409:SF32	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT BETA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	CHICK|Ensembl=ENSGALG00000009320|UniProtKB=Q4JIM4	Presenilin-1	IDA	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P04393	Ras Pathway	P04578	Rho	HUMAN|HGNC=668|UniProtKB=P62745	Rho-related GTP-binding protein RhoB	ISS	13679859	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DANRE|ZFIN=ZDB-GENE-040426-1178|UniProtKB=Q7SY24	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	RAT|RGD=69259|UniProtKB=O70240	Axin-2	IEP	12356903	PubMed	PTHR10845:SF103	AXIN-2
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	CANLF|Ensembl=ENSCAFG00000007637|UniProtKB=E2R0C6	Uncharacterized protein	ISS			PTHR24095:SF126	ACETYL-COENZYME A SYNTHETASE, CYTOPLASMIC
P00018	EGF receptor signaling pathway	P00551	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00632	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00938	Cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00990	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05992	met-Enkephalin	RAT|RGD=68946|UniProtKB=P04094	Proenkephalin-A	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00036	Interleukin signaling pathway	P00965	ERK	MACMU|Ensembl=ENSMMUG00000008503|UniProtKB=F6TGJ6	Uncharacterized protein	ISS	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P04393	Ras Pathway	P04556	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01319	PAK	CHICK|Ensembl=ENSGALG00000008058|UniProtKB=F1N8W8	Uncharacterized protein	ISS	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00018	EGF receptor signaling pathway	P00539	14-3-3	SCHMA|EnsemblGenome=Smp_034840|UniProtKB=G4V8A9	14-3-3 epsilon	IGI	11172812	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00373	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IGI	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04393	Ras Pathway	P04572	JNK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00012	Cadherin signaling pathway	P00470	F-actin	TRIVA|Gene=TVAG_090470|UniProtKB=A2FA04	Actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04395	Vasopressin synthesis	P04593	Glycopeptide	HUMAN|HGNC=8528|UniProtKB=P01178	Oxytocin-neurophysin 1	IC	6717565	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00052	TGF-beta signaling pathway	P01284	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2048|UniProtKB=P25099	Adenosine receptor A1	ISS	12515326	PubMed	PTHR24246:SF1	ADENOSINE RECEPTOR A1
P00057	Wnt signaling pathway	P01443	Phospholipase C	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00010	B cell activation	P00397	IKK	HUMAN|HGNC=1974|UniProtKB=O15111	Inhibitor of nuclear factor kappa-B kinase subunit alpha	IGI	12813046	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00021	FGF signaling pathway	P00648	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	11554554	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04384	Gamma-aminobutyric acid synthesis	P04482	Glutamate decarboxylase	MACMU|Ensembl=ENSMMUG00000015198|UniProtKB=F6W3S5	Uncharacterized protein	ISS	2247446	PubMed	PTHR11999:SF57	GLUTAMATE DECARBOXYLASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	DICPU|Gene=DICPUDRAFT_93216|UniProtKB=F1A421	Guanine nucleotide-binding protein subunit beta	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00556	PLCgamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IGI	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00052	TGF-beta signaling pathway	P01284	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	RAT|RGD=620209|UniProtKB=P48973	C-X-C motif chemokine 10	ISS	10946576	gi	PTHR10179:SF47	C-X-C MOTIF CHEMOKINE 10
P06664	Gonadotropin-releasing hormone receptor pathway	P06782	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	RCA	7925653	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00644	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IGI	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00012	Cadherin signaling pathway	P00470	F-actin	CAEEL|WormBase=WBGene00000063|UniProtKB=P0DM41	Actin-1	IC	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P02723	Adenine and hypoxanthine salvage pathway	P02811	Adenosine deaminase	MACMU|Ensembl=ENSMMUG00000010603|UniProtKB=F7CBG9	Uncharacterized protein	ISS			PTHR11409:SF43	ADENOSINE DEAMINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00830	Lipoxygenase	RAT|RGD=1307642|UniProtKB=D3ZQF9	Arachidonate 12-lipoxygenase, epidermal-type	ISS	12432925	PubMed	PTHR11771:SF34	ARACHIDONATE 12-LIPOXYGENASE, EPIDERMAL-TYPE
P00019	Endothelin signaling pathway	P00586	Gq	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MACMU|Ensembl=ENSMMUG00000005819|UniProtKB=F6VKI4	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P00046	Oxidative stress response	P01121	MKK3/6	BOVIN|Ensembl=ENSBTAG00000001609|UniProtKB=Q5E9X2	Dual specificity mitogen-activated protein kinase kinase 6	RCA			PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	TAS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00010	B cell activation	P00375	Calmodulin	BOVIN|Ensembl=ENSBTAG00000014583|UniProtKB=P62157	Calmodulin	ISS	10487978	PubMed	PTHR23050:SF335	CALMODULIN, STRIATED MUSCLE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P02753	Methionine biosynthesis	P03024	Homocysteine transmethylase	BACSU|EnsemblGenome=BSU11010|UniProtKB=O06745	Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase	ISS			PTHR21091:SF166	SUBFAMILY NOT NAMED
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	RAT|RGD=620218|UniProtKB=P15337	Cyclic AMP-responsive element-binding protein 1	ISS	11390664	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00931	Integrin beta	CANLF|Ensembl=ENSCAFG00000013735|UniProtKB=F1PPG5	Integrin beta	IDA	280842	gi	PTHR10082:SF25	INTEGRIN BETA-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00005	Angiogenesis	P00226	Delta/Serrate	BOVIN|Ensembl=ENSBTAG00000012817|UniProtKB=E1BDN7	Delta-like protein	ISS	8955070	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00035	Interferon-gamma signaling pathway	P00958	PIAS	CANLF|Ensembl=ENSCAFG00000017599|UniProtKB=E2RJ88	Uncharacterized protein	ISS	8682149	PubMed	PTHR10782:SF12	E3 SUMO-PROTEIN LIGASE PIAS2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01164	PDK1/2	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00009	Axon guidance mediated by netrin	P00366	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	RAT|RGD=3187|UniProtKB=Q07008	Neurogenic locus notch homolog protein 1	IDA	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00021	FGF signaling pathway	P00640	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P02775	Salvage pyrimidine ribonucleotides	P03149	Cytidine kinase	MONDO|Ensembl=ENSMODG00000017036|UniProtKB=F6Y033	Uridine kinase	ISS			PTHR10285:SF68	URIDINE-CYTIDINE KINASE-LIKE 1
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05918	p38 MAPK pathway	P06037	TAK1	MONDO|Ensembl=ENSMODG00000018170|UniProtKB=F7CCD5	Uncharacterized protein	ISS	10683140	PubMed	PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	ISS	91072385	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00964	p90RSK	CANLF|Ensembl=ENSCAFG00000013171|UniProtKB=E2RP04	Uncharacterized protein	ISS	10480933	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	XENTR|Xenbase=XB-GENE-1014202|UniProtKB=F6V946	Uncharacterized protein (Fragment)	ISS			PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00060	Ubiquitin proteasome pathway	P01494	19S proteasome	TAKRU|Ensembl=ENSTRUG00000006577|UniProtKB=H2SUR5	Uncharacterized protein	ISS			PTHR23073:SF8	26S PROTEASE REGULATORY SUBUNIT 6B
P00047	PDGF signaling pathway	P01167	Ets	HUMAN|HGNC=3492|UniProtKB=P41162	ETS translocation variant 3	ISS	15298723	PubMed	PTHR11849:SF30	ETS TRANSLOCATION VARIANT 3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	TAS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	CHICK|Ensembl=ENSGALG00000011558|UniProtKB=F1NWV6	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00470	F-actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347740|UniProtKB=E9FXV8	Cytoplasmatic actin	ISS	14684598	PubMed	PTHR11937:SF277	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04557	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IDA	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00047	PDGF signaling pathway	P01159	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	RCA	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	RAT|RGD=3187|UniProtKB=Q07008	Neurogenic locus notch homolog protein 1	IDA	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00047	PDGF signaling pathway	P01151	PKB	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	12086862	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01336	Jnk	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IGI	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MACMU|Ensembl=ENSMMUG00000017683|UniProtKB=F6UA63	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01093	AChE	PANTR|Ensembl=ENSPTRG00000019514|UniProtKB=H2R3Y8	Carboxylic ester hydrolase	ISS	87080761	PubMed	PTHR11559:SF356	ACETYLCHOLINESTERASE
P04395	Vasopressin synthesis	P04594	Neurophysin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P02751	Lysine biosynthesis	P03011	N-succinyldiaminopimelate  aminotransferase	ARATH|TAIR=AT1G80600|UniProtKB=Q9M8M7	Acetylornithine aminotransferase, chloroplastic/mitochondrial	IDA			PTHR11986:SF79	ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_115566|UniProtKB=C3XYC8	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00005	Angiogenesis	P00205	GAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	14707121	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05913	Enkephalin release	P05974	G-Protein (i)	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	MACMU|Ensembl=ENSMMUG00000018375|UniProtKB=F7H1D5	Neurogenic locus notch homolog protein 2 isoform 1 preproprotein	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P04393	Ras Pathway	P04578	Rho	MOUSE|MGI=MGI=107949|UniProtKB=P62746	Rho-related GTP-binding protein RhoB	ISS	11973360	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00057	Wnt signaling pathway	P01461	FrzB	BOVIN|Ensembl=ENSBTAG00000015366|UniProtKB=Q17QP5	Secreted frizzled-related protein 4	ISS	9118218	PubMed	PTHR11309:SF7	SECRETED FRIZZLED-RELATED PROTEIN 4
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	MOUSE|MGI=MGI=98729|UniProtKB=Q62312	TGF-beta receptor type-2	TAS	9759503	PubMed	PTHR23255:SF55	TGF-BETA RECEPTOR TYPE-2
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	XENTR|Xenbase=XB-GENE-977853|UniProtKB=F7EBE7	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	90172230	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00046	Oxidative stress response	P01129	JNK1/2	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008422|UniProtKB=F6VUT7	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00006	Apoptosis signaling pathway	P00313	IKK	HUMAN|HGNC=1974|UniProtKB=O15111	Inhibitor of nuclear factor kappa-B kinase subunit alpha	IDA	9346484	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01391	TFIIFalpha	MOUSE|MGI=MGI=1923848|UniProtKB=Q3THK3	General transcription factor IIF subunit 1	ISS	12732728	PubMed	PTHR13011:SF0	GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CHICK|Ensembl=ENSGALG00000027629|UniProtKB=Q5ZJ03	Guanine nucleotide-binding protein subunit gamma	IDA	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05730	Endogenous cannabinoid signaling	P05751	Galpha	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00038	JAK/STAT signaling pathway	P01034	Jak	CHICK|Ensembl=ENSGALG00000011031|UniProtKB=F1NMJ9	Tyrosine-protein kinase	ISS	11929133	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	ORNAN|Ensembl=ENSOANG00000004783|UniProtKB=F7FN72	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00029	Huntington disease	P00803	Sp1	RAT|RGD=3738|UniProtKB=Q01714	Transcription factor Sp1	RCA			PTHR23235:SF16	TRANSCRIPTION FACTOR SP1
P00057	Wnt signaling pathway	P01443	Phospholipase C	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IDA	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00015	Circadian clock system	P00505	Cry	ORNAN|Ensembl=ENSOANG00000005350|UniProtKB=F6X852	Uncharacterized protein	ISS	10428031	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	CHICK|Gene=JUN|UniProtKB=P18870	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00005	Angiogenesis	P00255	Notch	HUMAN|HGNC=7881|UniProtKB=P46531	Neurogenic locus notch homolog protein 1	IDA	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00006	Apoptosis signaling pathway	P00269	MAPK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00557	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	G01563	MDM-2	BOVIN|Ensembl=ENSBTAG00000010422|UniProtKB=F1MYE6	Uncharacterized protein	ISS	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000017612|UniProtKB=C7G3N0	Glutamate receptor, metabotropic 6	ISS	12351712	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MOUSE|MGI=MGI=98310|UniProtKB=Q60698	Ski oncogene	IGI	10485843	PubMed	PTHR10005:SF15	SKI ONCOGENE
P00021	FGF signaling pathway	P00627	ERK1-2	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	PANTR|Ensembl=ENSPTRG00000011672|UniProtKB=H2QHG6	Uncharacterized protein	ISS	12356903	PubMed	PTHR11514:SF3	N-MYC PROTO-ONCOGENE PROTEIN
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00054	Toll receptor signaling pathway	P01357	MEKK1	MACMU|Ensembl=ENSMMUG00000012387|UniProtKB=F7EB20	Uncharacterized protein	ISS	8643568	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00029	Huntington disease	P00790	beta-Tubulin	PHYPA|Gene=PHYPADRAFT_186458|UniProtKB=Q6TYR7	Beta-tubulin 1	ISS	12932731	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CAEBR|Gene=CBG05858|UniProtKB=A8X1H0	Protein CBR-EGL-19 (Fragment)	ISS	15737619	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00034	Integrin signalling pathway	P00912	Arp2/3	CANLF|Ensembl=ENSCAFG00000000132|UniProtKB=J9P309	Actin-related protein 2/3 complex subunit 3	ISS	12473693	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MONDO|Ensembl=ENSMODG00000001844|UniProtKB=F6SPF3	Uncharacterized protein (Fragment)	ISS	12834808	PubMed	PTHR10201:SF138	MATRIX METALLOPROTEINASE-24
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00051	TCA cycle	P01266	Pyruvate Dehydrogenase	PANTR|Ensembl=ENSPTRG00000009388|UniProtKB=H2QDE4	Uncharacterized protein	ISS			PTHR11947:SF15	PYRUVATE DEHYDROGENASE  ACETYL-TRANSFERRING   KINASE ISOZYME 2, MITOCHONDRIAL
P00047	PDGF signaling pathway	P01162	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	10514528	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00049	Parkinson disease	P01227	20S proteasome	DICPU|Gene=DICPUDRAFT_92891|UniProtKB=F0ZYX2	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF13	PROTEASOME SUBUNIT ALPHA TYPE-4
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04395	Vasopressin synthesis	P04593	Glycopeptide	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00053	T cell activation	P01330	IKK	CANLF|Ensembl=ENSCAFG00000009588|UniProtKB=E2RNA9	Uncharacterized protein	ISS	12235208	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00049	Parkinson disease	P01211	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	21071228	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	STRPU|EnsemblGenome=SPU_012329|UniProtKB=W4Y9B6	Uncharacterized protein	IC			PTHR19957:SF41	SYNTAXIN-1A
P04395	Vasopressin synthesis	P04593	Glycopeptide	HUMAN|HGNC=8528|UniProtKB=P01178	Oxytocin-neurophysin 1	IC	9756087	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00758	Phosducin	BOVIN|Gene=PDC|UniProtKB=P19632	Phosducin	ISS	10360181	PubMed	PTHR21148:SF17	PHOSDUCIN
P00053	T cell activation	P01336	Jnk	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00019	Endothelin signaling pathway	P00591	PLCbeta	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00034	Integrin signalling pathway	P00936	PI3K	CAEEL|WormBase=WBGene00006932|UniProtKB=Q9TXI7	Phosphatidylinositol 3-kinase catalytic subunit type 3	IPI	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00047	PDGF signaling pathway	P01150	PKC	CANAL|CGD=CAL0003231|UniProtKB=Q5ANK2	Protein kinase C	ISS	8813761	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P02746	Heme biosynthesis	P02976	Protoporphyrinogen oxidase	HUMAN|HGNC=9280|UniProtKB=P50336	Protoporphyrinogen oxidase	ISS			PTHR42923:SF3	PROTOPORPHYRINOGEN OXIDASE
P04398	p53 pathway feedback loops 2	P04664	cyclin E	MOUSE|MGI=MGI=88316|UniProtKB=Q61457	G1/S-specific cyclin-E1	ISS	12628165	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	XENTR|Xenbase=XB-GENE-493937|UniProtKB=Q5M8T9	Actin, alpha 2, smooth muscle, aorta	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P02752	Mannose metabolism	P03018	Mannose 1-P guanylyl transferase	SYNY3|Gene=BAA18697|UniProtKB=P74589	Mannose-1-phosphate guanyltransferase	ISS	8905231	PubMed	PTHR22572:SF124	SUBFAMILY NOT NAMED
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	MACMU|Ensembl=ENSMMUG00000003212|UniProtKB=F7EEK0	Transcription factor IIIB 50 kDa subunit	ISS			PTHR11618:SF5	TRANSCRIPTION FACTOR IIIB 50 KDA SUBUNIT
P02741	Flavin biosynthesis	P02933	Pyrimidine deaminase	SCHPO|PomBase=SPCC4G3.16|UniProtKB=P87241	Diaminohydroxyphosphoribosylamino-pyrimidine deaminase	ISS			PTHR14614:SF94	RIBOSOMAL LYSINE N-METHYLTRANSFERASE 5
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	ORNAN|Ensembl=ENSOANG00000006811|UniProtKB=F6WBD5	Uncharacterized protein	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00048	PI3 kinase pathway	P01185	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	TAS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00029	Huntington disease	P00780	Microtubule	MACMU|Ensembl=ENSMMUG00000032572|UniProtKB=F7D7Y7	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00029	Huntington disease	P00786	ARF	CAEEL|WormBase=WBGene00000187|UniProtKB=Q20758	ADP-ribosylation factor-like protein 1	IPI	12932731	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P00029	Huntington disease	P00799	JNK-2	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	P01438	PP2A	RAT|RGD=1305657|UniProtKB=A0A0G2JTA1	Protein Ppp2r5e	ISS	10092233	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	HUMAN|HGNC=5300|UniProtKB=P47898	5-hydroxytryptamine receptor 5A	IDA			PTHR24247:SF108	5-HYDROXYTRYPTAMINE RECEPTOR 5A
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT4G01370|UniProtKB=Q39024	Mitogen-activated protein kinase 4	ISS	9836510	gi	PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	RAT|RGD=71009|UniProtKB=P21932	Adenylate cyclase type 3	IGI	2491850	PubMed	PTHR11920:SF291	ADENYLATE CYCLASE TYPE 3
P00005	Angiogenesis	P00182	p38MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P01480	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00036	Interleukin signaling pathway	P00973	PKB	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PANTR|Ensembl=ENSPTRG00000008769|UniProtKB=H2R9J3	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF681	MYOSIN-4
P00017	DNA replication	P00534	PCNA	HALSA|EnsemblGenome=VNG_2256G|UniProtKB=Q9HN45	DNA polymerase sliding clamp	ISS	20504483	PubMed	PTHR11352:SF0	PROLIFERATING CELL NUCLEAR ANTIGEN
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00050	Plasminogen activating cascade	P01255	Plasminogen	PANTR|Ensembl=ENSPTRG00000018774|UniProtKB=H2QU06	Plasminogen	ISS	2318848	PubMed	PTHR24261:SF6	PLASMINOGEN
P02738	De novo purine biosynthesis	P02900	AICAR transformylase	AQUAE|EnsemblGenome=aq_1963|UniProtKB=O67775	Bifunctional purine biosynthesis protein PurH	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P04393	Ras Pathway	P04570	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	BOVIN|Ensembl=ENSBTAG00000008059|UniProtKB=P41984	Muscarinic acetylcholine receptor M3	ISS	8100450	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00054	Toll receptor signaling pathway	P01338	IkappaB	MOUSE|MGI=MGI=104741|UniProtKB=Q9Z1E3	NF-kappa-B inhibitor alpha	ISS	12637573	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MONDO|Ensembl=ENSMODG00000018204|UniProtKB=F6PGX6	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04384	Gamma-aminobutyric acid synthesis	P04482	Glutamate decarboxylase	CAEEL|WormBase=WBGene00006762|UniProtKB=G5EDB7	Glutamic acid decarboxylase	ISS	2247446	PubMed	PTHR11999:SF137	GLUTAMATE DECARBOXYLASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00029	Huntington disease	P00786	ARF	TRIAD|EnsemblGenome=TriadG63238|UniProtKB=B3RQZ1	ADP-ribosylation factor 1	ISS	12932731	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00760	Gtalpha	MACMU|Ensembl=ENSMMUG00000010339|UniProtKB=F6R9V5	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF67	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	IC	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	6264430	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	DROME|FlyBase=FBgn0004360|UniProtKB=P28465	Protein Wnt-2	TAS	8717036	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00005	Angiogenesis	P00187	beta catenin	TAKRU|Ensembl=ENSTRUG00000003520|UniProtKB=H2S791	Uncharacterized protein	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05731	GABA-B receptor II signaling	P05754	Ggamma	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00019	Endothelin signaling pathway	P00570	PKA	DROME|FlyBase=FBgn0000489|UniProtKB=P16912	Protein kinase DC2	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DICPU|Gene=DICPUDRAFT_92985|UniProtKB=F1A084	Putative uncharacterized protein rac1A	ISS	21127961	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00053	T cell activation	P01335	jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	MACMU|Ensembl=ENSMMUG00000017017|UniProtKB=F7FVL2	Tyrosine-protein kinase	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00057	Wnt signaling pathway	P01438	PP2A	MONDO|Ensembl=ENSMODG00000002945|UniProtKB=F6PKB8	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	IDA	12039949	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P05916	Opioid prodynorphin pathway	P06000	vasopressin	DANRE|ZFIN=ZDB-GENE-030407-2|UniProtKB=F8W5D0	Uncharacterized protein (Fragment)	ISS			PTHR11681:SF13	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01026	KA	HUMAN|HGNC=4579|UniProtKB=P39086	Glutamate receptor ionotropic, kainate 1	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	PANTR|Ensembl=ENSPTRG00000006510|UniProtKB=H2Q8K1	Presenilin	ISS	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P00056	VEGF signaling pathway	P01417	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00056	VEGF signaling pathway	P01425	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	PANTR|Ensembl=ENSPTRG00000014949|UniProtKB=H2QMN3	Uncharacterized protein	ISS	6264430	PubMed	PTHR10218:SF67	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000009626|UniProtKB=F6ZYQ0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00054	Toll receptor signaling pathway	P01358	ERK1	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00036	Interleukin signaling pathway	P00972	MNK1/2	MOUSE|MGI=MGI=894279|UniProtKB=Q8CDB0	MAP kinase-interacting serine/threonine-protein kinase 2	IC	11463832	PubMed	PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P00018	EGF receptor signaling pathway	P00560	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00057	Wnt signaling pathway	P01451	Galpha	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	ARATH|TAIR=AT3G47290|UniProtKB=Q9STZ3	Phosphoinositide phospholipase C 8	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00006	Apoptosis signaling pathway	P00267	MADD	HUMAN|HGNC=6766|UniProtKB=Q8WXG6	MAP kinase-activating death domain protein	IDA	9115275	PubMed	PTHR13008:SF7	MAP KINASE-ACTIVATING DEATH DOMAIN PROTEIN
P00010	B cell activation	P00384	p38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00005	Angiogenesis	P00211	GSK3beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00048	PI3 kinase pathway	P01198	FOXO	MOUSE|MGI=MGI=1890077|UniProtKB=Q9R1E0	Forkhead box protein O1	TAS	10347145	PubMed	PTHR11829:SF159	FORKHEAD BOX PROTEIN O1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MACMU|Gene=CHRM1|UniProtKB=P56489	Muscarinic acetylcholine receptor M1	TAS	11166329	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	MACMU|Ensembl=ENSMMUG00000009962|UniProtKB=F6RBM2	Thyroid stimulating hormone beta subunit	ISS	5101174	PubMed	PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	ISS	1504106	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00001	Adrenaline and noradrenaline biosynthesis	P00069	COMT	RAT|RGD=2379|UniProtKB=P22734	Catechol O-methyltransferase	ISS	12842307	PubMed	PTHR43836:SF3	CATECHOL O-METHYLTRANSFERASE
P04397	p53 pathway by glucose deprivation	P04640	p53	PANTR|Ensembl=ENSPTRG00000008703|UniProtKB=H2QC53	Cellular tumor antigen p53	ISS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	10644715	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	BOVIN|Ensembl=ENSBTAG00000033153|UniProtKB=F1MG21	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00021	FGF signaling pathway	P00644	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00034	Integrin signalling pathway	P00916	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000003043|UniProtKB=P63212	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00021	FGF signaling pathway	P00636	FGFR1-4	HUMAN|HGNC=3691|UniProtKB=P22455	Fibroblast growth factor receptor 4	IPI	11549253	PubMed	PTHR24416:SF343	FIBROBLAST GROWTH FACTOR RECEPTOR 4
P00018	EGF receptor signaling pathway	P00560	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00973	PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P02734	Chorismate biosynthesis	P02872	3-Dehydroquinate synthase	RHOBA|EnsemblGenome=RB1898|UniProtKB=Q7UWN8	3-dehydroquinate synthase	ISS			PTHR43622:SF1	3-DEHYDROQUINATE SYNTHASE
P00010	B cell activation	P00375	Calmodulin	CHICK|Gene_ORFName=RCJMB04_24e7|UniProtKB=P62149	Calmodulin	ISS	3885394	PubMed	PTHR23050:SF311	CALMODULIN
P00038	JAK/STAT signaling pathway	P01027	STAT	RAT|RGD=3772|UniProtKB=P52631	Signal transducer and activator of transcription 3	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05913	Enkephalin release	P05975	GPCR (s)	BOVIN|Gene=OPRM1|UniProtKB=P79350	Mu-type opioid receptor	ISS	11259487	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	RAT|RGD=621060|UniProtKB=O88777	Presenilin-2	TAS	9332390	PubMed	PTHR10202:SF13	PRESENILIN-2
P00021	FGF signaling pathway	P00637	MKK4,7	RAT|RGD=1560043|UniProtKB=Q4KSH7	Dual specificity mitogen-activated protein kinase kinase 7	RCA			PTHR24361:SF387	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7
P00010	B cell activation	P00371	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	TAS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04393	Ras Pathway	P04543	MEKK1/4	MACMU|Ensembl=ENSMMUG00000012387|UniProtKB=F7EB20	Uncharacterized protein	ISS	8643568	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00047	PDGF signaling pathway	P01151	PKB	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	MONDO|Ensembl=ENSMODG00000014177|UniProtKB=F6U7A6	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01236	Casein kinase II	MACMU|Ensembl=ENSMMUG00000015892|UniProtKB=F7BVK0	Uncharacterized protein	ISS	10806215	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	88234494	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00011	Blood coagulation	P00406	Fibrinogen	MACMU|Ensembl=ENSMMUG00000021302|UniProtKB=F6UZ87	Uncharacterized protein	ISS	6575700	PubMed	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CHICK|Ensembl=ENSGALG00000019382|UniProtKB=E1BWK1	Uncharacterized protein	ISS	11431030	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00006	Apoptosis signaling pathway	P00302	ATF	BOVIN|Gene=CREB1|UniProtKB=P27925	Cyclic AMP-responsive element-binding protein 1	ISS	11752053	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00965	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01080	AChE	RAT|RGD=619996|UniProtKB=Q9JKC1	Carboxylic ester hydrolase	IC			PTHR43918:SF5	CHOLINESTERASE
P06213	DPP signaling pathway	P06279	MED	DROME|FlyBase=FBgn0011648|UniProtKB=P42003	Protein mothers against dpp	RCA			PTHR13703:SF40	PROTEIN MOTHERS AGAINST DPP
P00021	FGF signaling pathway	P00630	RKIP	ARATH|TAIR=AT4G20370|UniProtKB=Q9S7R5	Protein TWIN SISTER of FT	ISS			PTHR11362:SF9	PROTEIN FLOWERING LOCUS T-RELATED
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00021	FGF signaling pathway	P00633	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04496	Mdm2	DANRE|ZFIN=ZDB-GENE-990415-153|UniProtKB=O42354	E3 ubiquitin-protein ligase Mdm2	IGI	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000009626|UniProtKB=F6ZYQ0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00016	Cytoskeletal regulation by Rho GTPase	P00521	Profilin	RAT|RGD=621826|UniProtKB=Q9EPC6	Profilin-2	ISS			PTHR13936:SF15	PROFILIN-2
P02746	Heme biosynthesis	P02983	Hydroxymethylbilane synthase	MYCTU|EnsemblGenome=Rv0510|UniProtKB=P9WMP3	Porphobilinogen deaminase	ISS			PTHR11557:SF0	PORPHOBILINOGEN DEAMINASE
P00019	Endothelin signaling pathway	P00586	Gq	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02787	Vitamin B6 metabolism	P03244	Pyridoxal kinase	RAT|RGD=621324|UniProtKB=O35331	Pyridoxal kinase	ISS	20344886	gi	PTHR10534:SF2	PYRIDOXAL KINASE
P00010	B cell activation	P00393	CD19	MACMU|Ensembl=ENSMMUG00000006880|UniProtKB=F7F486	Uncharacterized protein	ISS	9653091	PubMed	PTHR16674:SF2	B-LYMPHOCYTE ANTIGEN CD19
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02743	Formyltetrahydroformate biosynthesis	P02952	Methylene tetrahydrofolate dehydrogenase	MOUSE|MGI=MGI=1338850|UniProtKB=P18155	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	ISS			PTHR10025:SF39	BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, MITOCHONDRIAL
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00890	ELK	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	ISS	3183861	gi	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00034	Integrin signalling pathway	P00912	Arp2/3	DROME|FlyBase=FBgn0032859|UniProtKB=Q9VIM5	Actin-related protein 2/3 complex subunit 2	IPI	17943202	gi	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00049	Parkinson disease	P01238	14-3-3	ORNAN|Ensembl=ENSOANG00000004145|UniProtKB=F7A0H3	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000012036|UniProtKB=F7ALP1	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00010	B cell activation	P00391	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00628	JNK1-3	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IGI	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	PANTR|Ensembl=ENSPTRG00000020039|UniProtKB=H2R9W1	Uncharacterized protein	ISS	92370677	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P05918	p38 MAPK pathway	P06029	p38beta	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	RCA	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	CANLF|Gene=DRD2|UniProtKB=Q9GJU1	D(2) dopamine receptor	ISS	2039532	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MACMU|Ensembl=ENSMMUG00000017431|UniProtKB=F7HPP3	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	MACMU|Ensembl=ENSMMUG00000012422|UniProtKB=F7DJH4	Tyrosine-protein kinase receptor	ISS	10226785	PubMed	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00057	Wnt signaling pathway	P01438	PP2A	CANLF|Ensembl=ENSCAFG00000014047|UniProtKB=F1PV54	Uncharacterized protein	ISS	11531413	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00012	Cadherin signaling pathway	P00470	F-actin	CAEEL|WormBase=WBGene00000067|UniProtKB=O45815	ACTin	IC	3487386	PubMed	PTHR11937:SF352	ACTIN
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	HUMAN|HGNC=17296|UniProtKB=Q7LG56	Ribonucleoside-diphosphate reductase subunit M2 B	ISS			PTHR23409:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 B
P02734	Chorismate biosynthesis	P02872	3-Dehydroquinate synthase	CHLTR|EnsemblGenome=CT_369|UniProtKB=O84374	3-dehydroquinate synthase	ISS			PTHR43622:SF1	3-DEHYDROQUINATE SYNTHASE
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00046	Oxidative stress response	P01129	JNK1/2	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	TAS	10207617	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_126324|UniProtKB=C3XYC2	Putative uncharacterized protein	IDA	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04375	5HT3 type receptor mediated signaling pathway	P04422	5HT3 Rec	MACMU|Ensembl=ENSMMUG00000007080|UniProtKB=F7ES21	Uncharacterized protein	ISS	7509203	PubMed	PTHR18945:SF52	5-HYDROXYTRYPTAMINE RECEPTOR 3A
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	HUMAN|HGNC=5465|UniProtKB=P08069	Insulin-like growth factor 1 receptor	TAS	6754360	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00021	FGF signaling pathway	P00645	Rac	DROME|FlyBase=FBgn0010333|UniProtKB=P40792	Ras-related protein Rac1	IGI	12932731	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	ORNAN|Ensembl=ENSOANG00000012115|UniProtKB=F7F9Q9	Uncharacterized protein	ISS	10617630	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	TAS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	TAS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00006	Apoptosis signaling pathway	P00260	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00018	EGF receptor signaling pathway	P00543	ERK1-2	ARATH|TAIR=AT3G18040|UniProtKB=Q9LV37	Mitogen-activated protein kinase 9	IGI			PTHR24055:SF246	MITOGEN-ACTIVATED PROTEIN KINASE 15-RELATED
P00006	Apoptosis signaling pathway	P00297	NFkappaB	MACMU|Ensembl=ENSMMUG00000002990|UniProtKB=F7GVV0	Uncharacterized protein	ISS	9133421	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00045	Notch signaling pathway	P01101	Su(H)	CANLF|Ensembl=ENSCAFG00000016387|UniProtKB=E2QV83	Uncharacterized protein	ISS	12145413	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00010	B cell activation	P00385	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00195	APC	HUMAN|HGNC=24036|UniProtKB=O95996	Adenomatous polyposis coli protein 2	ISS	10491393	PubMed	PTHR12607:SF3	ADENOMATOUS POLYPOSIS COLI PROTEIN 2
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	ISS	15860573	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P02738	De novo purine biosynthesis	P02907	dADP kinase	BOVIN|Ensembl=ENSBTAG00000008752|UniProtKB=E1BDQ6	Uncharacterized protein	ISS			PTHR11349:SF64	NUCLEOSIDE DIPHOSPHATE KINASE HOMOLOG 5
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00007	Axon guidance mediated by semaphorins	P00340	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	10540223	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00049	Parkinson disease	P01208	Hsp70	PLAF7|EnsemblGenome=PFI0875w|UniProtKB=Q8I2X4	Heat shock protein 70	IDA	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=88356|UniProtKB=P10287	Cadherin-3	IDA	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	TAKRU|Ensembl=ENSTRUG00000005447|UniProtKB=P68142	Actin, cytoplasmic 1	IDA	11889126	PubMed	PTHR11937:SF354	SUBFAMILY NOT NAMED
P00059	p53 pathway	G04702	p53	RAT|RGD=1307083|UniProtKB=D4AA88	Protein Tp73	ISS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P04386	Histamine H2 receptor mediated signaling pathway	P04489	H2	PANTR|Ensembl=ENSPTRG00000017551|UniProtKB=P60021	Histamine H2 receptor	ISS	8817552	PubMed	PTHR43893:SF5	HISTAMINE H2 RECEPTOR
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	TAS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00021	FGF signaling pathway	P00629	PP2A	MOUSE|MGI=MGI=1349473|UniProtKB=Q61151	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	ISS	10092233	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P02761	Pantothenate biosynthesis	P03066	Aspartate decarboxylase	STRCO|EnsemblGenome=CAC44328|UniProtKB=P58286	Aspartate 1-decarboxylase	ISS			PTHR21012:SF0	ASPARTATE 1-DECARBOXYLASE
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	IDA	12885769	PubMed	PTHR10202:SF13	PRESENILIN-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04585	TRH	HUMAN|HGNC=12372|UniProtKB=P01222	Thyrotropin subunit beta	ISS			PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	XENTR|Xenbase=XB-GENE-957124|UniProtKB=F7BDN8	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00021	FGF signaling pathway	P00627	ERK1-2	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00640	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IGI	96009592	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IPI	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00019	Endothelin signaling pathway	P00570	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00221	JNK1	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	HUMAN|HGNC=11542|UniProtKB=Q16594	Transcription initiation factor TFIID subunit 9	ISS			PTHR12595:SF8	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 9
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	IC	15737619	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CHICK|Ensembl=ENSGALG00000006638|UniProtKB=R4GGL9	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00018	EGF receptor signaling pathway	P00564	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	CHICK|Gene=JUN|UniProtKB=P18870	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00018	EGF receptor signaling pathway	P00552	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02787	Vitamin B6 metabolism	P03244	Pyridoxal kinase	MOUSE|MGI=MGI=1351869|UniProtKB=Q8K183	Pyridoxal kinase	NAS	20344886	gi	PTHR10534:SF2	PYRIDOXAL KINASE
P00046	Oxidative stress response	P01135	p38	CAEEL|WormBase=WBGene00004056|UniProtKB=Q8MXI4	Mitogen-activated protein kinase pmk-2	TAS	11274345	PubMed	PTHR24055:SF154	MITOGEN-ACTIVATED PROTEIN KINASE PMK-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00780	Microtubule	CHICK|Ensembl=ENSGALG00000012821|UniProtKB=P32882	Tubulin beta-2 chain	IDA	9454836	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00049	Parkinson disease	P01227	20S proteasome	ANOGA|EnsemblGenome=AGAP001995|UniProtKB=Q8T0Y8	Proteasome subunit alpha type	TAS	12859888	PubMed	PTHR11599:SF16	PROTEASOME SUBUNIT ALPHA TYPE-2
P00047	PDGF signaling pathway	P01154	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00018	EGF receptor signaling pathway	P00541	Spry	BOVIN|Ensembl=ENSBTAG00000008250|UniProtKB=A2VDU1	Protein sprouty homolog 4	ISS	22024232	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P00010	B cell activation	P00398	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00053	T cell activation	P01300	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MACMU|Ensembl=ENSMMUG00000010440|UniProtKB=F7CRV6	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00046	Oxidative stress response	P01135	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	TAS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	8787761	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00810	GAPDH	HUMAN|HGNC=4141|UniProtKB=P04406	Glyceraldehyde-3-phosphate dehydrogenase	IPI	8612237	PubMed	PTHR10836:SF51	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE
P00052	TGF-beta signaling pathway	P01275	P38	CAEEL|WormBase=WBGene00004055|UniProtKB=Q17446	Mitogen-activated protein kinase pmk-1	TAS	22138445	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	ISS	14698601	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P02775	Salvage pyrimidine ribonucleotides	P03149	Cytidine kinase	YEAST|SGD=S000005295|UniProtKB=P27515	Uridine kinase	ISS			PTHR10285:SF123	URIDINE KINASE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04393	Ras Pathway	P04557	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00005	Angiogenesis	P00234	Grb2	RAT|RGD=1306884|UniProtKB=Q4KM68	GRB2-related adaptor protein	ISS			PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P00036	Interleukin signaling pathway	P00994	FKHRL1	PANTR|Ensembl=ENSPTRG00000018476|UniProtKB=H2R710	Forkhead box O3	ISS	14775847	gi	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00030	Hypoxia response via HIF activation	P00819	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01147	Nck	MACMU|Ensembl=ENSMMUG00000007389|UniProtKB=F7E0A3	Cytoplasmic protein NCK1 isoform 1	ISS	12874226	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	PANTR|Ensembl=ENSPTRG00000018629|UniProtKB=H2QTS3	Uncharacterized protein	ISS			PTHR43720:SF2	ALDEHYDE DEHYDROGENASE FAMILY 8 MEMBER A1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000003762|UniProtKB=A5PJS1	GNB5 protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00010	B cell activation	P00387	CD22	MOUSE|MGI=MGI=88322|UniProtKB=P35329	B-cell receptor CD22	IPI	11551923	PubMed	PTHR12035:SF60	B-CELL RECEPTOR CD22
P04393	Ras Pathway	P04555	PDK	ARATH|TAIR=AT5G04510|UniProtKB=Q9XF67	3-phosphoinositide-dependent protein kinase 1	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P02728	Arginine biosynthesis	P02840	Argininosuccinate synthase	ARATH|TAIR=AT4G24830|UniProtKB=Q9SZX3	Argininosuccinate synthase, chloroplastic	ISS			PTHR11587:SF2	ARGININOSUCCINATE SYNTHASE
P00006	Apoptosis signaling pathway	P00260	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00190	RasGAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	227170	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	RAT|RGD=620596|UniProtKB=O08556	C-C chemokine receptor type 5	ISS			PTHR10489:SF686	C-C CHEMOKINE RECEPTOR TYPE 5
P00057	Wnt signaling pathway	P01438	PP2A	BOVIN|Ensembl=ENSBTAG00000007061|UniProtKB=Q08DP7	Protein phosphatase 2, regulatory subunit B', beta isoform	ISS	96161994	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00539	14-3-3	XENTR|Xenbase=XB-GENE-951350|UniProtKB=Q0V9W8	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	ISS	8381897	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00048	PI3 kinase pathway	P01181	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BRAFL|Gene=BRAFLDRAFT_220697|UniProtKB=C3ZSF0	Putative uncharacterized protein	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347742|UniProtKB=E9FZ00	Cytoplasmatic actin	ISS	14684598	PubMed	PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00047	PDGF signaling pathway	P01158	PDGF receptor A	PANTR|Ensembl=ENSPTRG00000016066|UniProtKB=H2QPH4	Uncharacterized protein	RCA			PTHR24416:SF52	PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05752	PKA	DICDI|dictyBase=DDB_G0283907|UniProtKB=P34099	cAMP-dependent protein kinase catalytic subunit	RCA	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	BOVIN|Gene=CACNB1|UniProtKB=Q9MZL7	Voltage-dependent L-type calcium channel subunit beta-1	ISS	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	ORNAN|Ensembl=ENSOANG00000000467|UniProtKB=F7F4P1	Uncharacterized protein	ISS	10391901	PubMed	PTHR15936:SF2	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-13
P00018	EGF receptor signaling pathway	P00551	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MACMU|Ensembl=ENSMMUG00000014227|UniProtKB=P56490	Muscarinic acetylcholine receptor M5	TAS	8100450	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02781	Threonine biosynthesis	P03188	Homoserine dehydrogenase	STRCO|Gene=CAB59717|UniProtKB=Q9RJR6	Homoserine dehydrogenase	ISS			PTHR43331:SF1	SUBFAMILY NOT NAMED
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PHYIT|EnsemblGenome=PITG_15078|UniProtKB=D0NRL5	Actin-like protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00025	Hedgehog signaling pathway	P00682	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MACMU|Ensembl=ENSMMUG00000006295|UniProtKB=F7GZ45	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF166	MATRIX METALLOPROTEINASE-19
P00049	Parkinson disease	P01230	Src kinase	XENTR|Xenbase=XB-GENE-6053489|UniProtKB=F6S8L5	Tyrosine-protein kinase	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MOUSE|MGI=MGI=2150393|UniProtKB=Q91ZU9	Glutamate receptor ionotropic, NMDA 3B	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00857	IkappaB	RAT|RGD=3171|UniProtKB=Q63746	NF-kappa-B inhibitor alpha	ISS	10869418	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00006	Apoptosis signaling pathway	P00302	ATF	CHICK|Ensembl=ENSGALG00000012135|UniProtKB=F6V5T5	Uncharacterized protein	ISS	11390664	PubMed	PTHR13044:SF2	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-4
P00047	PDGF signaling pathway	P01167	Ets	PANTR|Ensembl=ENSPTRG00000001844|UniProtKB=H2Q0W5	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF13	ETS-RELATED TRANSCRIPTION FACTOR ELF-3
P00054	Toll receptor signaling pathway	P01375	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04398	p53 pathway feedback loops 2	P04657	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01152	RasGAP	ORNAN|Ensembl=ENSOANG00000014753|UniProtKB=F7EPN2	Uncharacterized protein (Fragment)	ISS	15489039	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00010	B cell activation	P00383	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00045	Notch signaling pathway	P01119	NIct	RAT|RGD=620761|UniProtKB=Q9R172	Neurogenic locus notch homolog protein 3	ISS	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04586	ProTRH (Pro Thyrotropin-releasing Hormone)	PANTR|Ensembl=ENSPTRG00000001144|UniProtKB=H2PZR0	Uncharacterized protein	ISS			PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P00004	Alzheimer disease-presenilin pathway	P00127	APP	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00034	Integrin signalling pathway	P00912	Arp2/3	RAT|RGD=1311985|UniProtKB=B2GV73	Actin-related protein 2/3 complex subunit 3	ISS	9359840	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00019	Endothelin signaling pathway	P00570	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05917	Opioid proopiomelanocortin pathway	P06004	Mu or Delta receptor	MACMU|Ensembl=ENSMMUG00000009389|UniProtKB=F7HEV7	Uncharacterized protein	ISS	12093103	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	STRPU|EnsemblGenome=SPU_018419|UniProtKB=W4YRI6	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=1921305|UniProtKB=Q8K4S1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	12176394	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00056	VEGF signaling pathway	P01407	Erk	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00627	ERK1-2	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00038	JAK/STAT signaling pathway	P01033	PTP	CHICK|Ensembl=ENSGALG00000002192|UniProtKB=F1NVB1	Uncharacterized protein	ISS	8940015	PubMed	PTHR19134:SF284	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	PANTR|Ensembl=ENSPTRG00000021182|UniProtKB=H2QXK2	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF61	TGF-BETA RECEPTOR TYPE-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00010	B cell activation	P00371	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00030	Hypoxia response via HIF activation	P00814	P300	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	IDA	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04398	p53 pathway feedback loops 2	G04714	PTEN	TAKRU|Ensembl=ENSTRUG00000009851|UniProtKB=H2TJ90	Uncharacterized protein	IGI	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00006	Apoptosis signaling pathway	P00292	IkappaB	CANLF|Ensembl=ENSCAFG00000013418|UniProtKB=E2RML9	Uncharacterized protein	ISS	10811867	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	PANTR|Ensembl=ENSPTRG00000003383|UniProtKB=H2Q376	Uncharacterized protein	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=4599|UniProtKB=Q14831	Metabotropic glutamate receptor 7	IDA	9407094	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	PANTR|Ensembl=ENSPTRG00000020539|UniProtKB=H2QWM9	Collagen, type XIV, alpha 1	ISS	10778855	PubMed	PTHR44557:SF1	COLLAGEN ALPHA-1 XIV  CHAIN
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	YEAST|SGD=S000004170|UniProtKB=P10659	S-adenosylmethionine synthase 1	ISS			PTHR11964:SF1	S-ADENOSYLMETHIONINE SYNTHASE
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	IGI	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P02748	Isoleucine biosynthesis	P02994	Branched chain amino acid aminotransferase	RAT|RGD=68948|UniProtKB=O35854	Branched-chain-amino-acid aminotransferase, mitochondrial	ISS			PTHR11825:SF39	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, MITOCHONDRIAL
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	BOVIN|Gene=CACNB1|UniProtKB=Q9MZL7	Voltage-dependent L-type calcium channel subunit beta-1	IC	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00049	Parkinson disease	P01227	20S proteasome	HUMAN|HGNC=9531|UniProtKB=P25787	Proteasome subunit alpha type-2	ISS	12859888	PubMed	PTHR11599:SF16	PROTEASOME SUBUNIT ALPHA TYPE-2
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00020	FAS signaling pathway	P00620	CytochromeC	IXOSC|EnsemblGenome=ISCW016731|UniProtKB=B7P8B3	Cytochrome c1, putative	ISS	9027315	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00049	Parkinson disease	P01227	20S proteasome	MOUSE|MGI=MGI=1347060|UniProtKB=Q9R1P0	Proteasome subunit alpha type-4	ISS	12859888	PubMed	PTHR11599:SF13	PROTEASOME SUBUNIT ALPHA TYPE-4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	ISS	98382502	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01335	jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00036	Interleukin signaling pathway	P00990	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01026	KA	XENTR|Xenbase=XB-GENE-957124|UniProtKB=F7BDN8	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00047	PDGF signaling pathway	P01162	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00024	Glycolysis	P00673	Triosephosphate isomerase	HUMAN|HGNC=12009|UniProtKB=P60174	Triosephosphate isomerase	RCA			PTHR21139:SF15	TRIOSEPHOSPHATE ISOMERASE
P00060	Ubiquitin proteasome pathway	P01491	E2	EMENI|EnsemblGenome=CADANIAG00003751|UniProtKB=Q96UP5	Ubiquitin-conjugating enzyme E2 2	ISS			PTHR43898:SF1	UBIQUITIN-CONJUGATING ENZYME E2-17 KDA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00892	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8235613	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00018	EGF receptor signaling pathway	P00556	PLCgamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IGI	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00627	ERK1-2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00022	General transcription by RNA polymerase I	P00657	TBP	TAKRU|Ensembl=ENSTRUG00000009283|UniProtKB=Q6SJ94	TATA box-binding protein-like protein 2	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00049	Parkinson disease	P01238	14-3-3	CAEEL|WormBase=WBGene00001502|UniProtKB=Q20655	14-3-3-like protein 2	IDA	10407019	PubMed	PTHR18860:SF13	14-3-3 PROTEIN ZETA
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	PANTR|Gene=CHRNA5|UniProtKB=Q5IS51	Neuronal acetylcholine receptor subunit alpha-5	ISS	85270494	PubMed	PTHR18945:SF76	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	IDA	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00049	Parkinson disease	P01238	14-3-3	ORNAN|Ensembl=ENSOANG00000007305|UniProtKB=F6XW91	Uncharacterized protein	ISS	1499718	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	PANTR|Ensembl=ENSPTRG00000023062|UniProtKB=H2R2U1	Catenin (Cadherin-associated protein), beta 1, 88kDa	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IDA	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00004	Alzheimer disease-presenilin pathway	P00178	BACE-1 pro-domain	HUMAN|HGNC=934|UniProtKB=Q9Y5Z0	Beta-secretase 2	IDA			PTHR13683:SF262	BETA-SECRETASE 2
P00053	T cell activation	P01336	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IGI	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00021	FGF signaling pathway	P00629	PP2A	BOVIN|Ensembl=ENSBTAG00000005533|UniProtKB=F1N1S8	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04407	K+ channel	BOVIN|Ensembl=ENSBTAG00000047488|UniProtKB=G3N1D1	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00003	Alzheimer disease-amyloid secretase pathway	P00094	BACE-1 pro-domain	MONDO|Ensembl=ENSMODG00000013692|UniProtKB=F6QP52	Uncharacterized protein	ISS	10956649	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g239788|UniProtKB=A7RPI8	Predicted protein	ISS	10487978	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00029	Huntington disease	P00780	Microtubule	SCHMA|EnsemblGenome=Smp_079970|UniProtKB=G4VTA5	Putative tubulin beta chain	ISS	9454836	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00045	Notch signaling pathway	P01103	Next	CANLF|Ensembl=ENSCAFG00000005627|UniProtKB=E2QUR0	Delta-like protein	ISS	10551863	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00053	T cell activation	P01336	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000005917|UniProtKB=F6QM53	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04395	Vasopressin synthesis	P04599	Amidating Enzyme	PANTR|Ensembl=ENSPTRG00000017110|UniProtKB=H2R5G8	Uncharacterized protein	ISS	3153462	PubMed	PTHR10680:SF14	PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE
P00018	EGF receptor signaling pathway	P00561	STAT	MOUSE|MGI=MGI=103038|UniProtKB=P42227	Signal transducer and activator of transcription 3	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04393	Ras Pathway	P04578	Rho	MONDO|Ensembl=ENSMODG00000012981|UniProtKB=F7CS91	Uncharacterized protein	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	ISS	91056091	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00015	Circadian clock system	G01497	cry	ORNAN|Ensembl=ENSOANG00000005350|UniProtKB=F6X852	Uncharacterized protein	ISS	14507900	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00020	FAS signaling pathway	P00616	Nuclear Lamin	MOUSE|MGI=MGI=96794|UniProtKB=P48678	Prelamin-A/C	TAS	11165516	PubMed	PTHR23239:SF158	PRELAMIN-A/C
P00047	PDGF signaling pathway	P01163	c-Jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	12972619	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00030	Hypoxia response via HIF activation	P00823	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02738	De novo purine biosynthesis	P02894	IMP cyclohydrolase	RAT|RGD=70879|UniProtKB=O35567	Bifunctional purine biosynthesis protein PURH	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	TAS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	MACMU|Ensembl=ENSMMUG00000013047|UniProtKB=F7H808	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01211	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	IDA	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	IC	11554549	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P05915	Opioid proenkephalin pathway	P05985	Mu or Delta receptor	MOUSE|MGI=MGI=97441|UniProtKB=P42866	Mu-type opioid receptor	RCA	11259487	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00036	Interleukin signaling pathway	P00994	FKHRL1	BOVIN|Ensembl=ENSBTAG00000011234|UniProtKB=F1N4K5	Uncharacterized protein	ISS	12048180	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00020	FAS signaling pathway	P00620	CytochromeC	ORYSJ|EnsemblGenome=OS01G0935700|UniProtKB=Q942X6	Os01g0935700 protein	IGI	9027315	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	ANOGA|EnsemblGenome=AGAP006818|UniProtKB=Q7QIF4	AGAP006818-PA	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS			PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04393	Ras Pathway	P04542	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00702	CPB	MOUSE|MGI=MGI=99946|UniProtKB=Q61817	Cyclic AMP-responsive element-binding protein 3	IDA			PTHR22952:SF100	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3
P00059	p53 pathway	G01575	GADD45	MOUSE|MGI=MGI=107776|UniProtKB=P22339	Growth arrest and DNA damage-inducible protein GADD45 beta	IGI	10097101	PubMed	PTHR10411:SF5	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 BETA
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	MONDO|Ensembl=ENSMODG00000008900|UniProtKB=F7B4C1	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P05730	Endogenous cannabinoid signaling	P05748	mGluR	MACMU|Ensembl=ENSMMUG00000010184|UniProtKB=F6SR09	Uncharacterized protein	ISS	8314195	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00010	B cell activation	P00402	Jnk	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05918	p38 MAPK pathway	P06020	p38delta	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00243	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	RAT|RGD=3425|UniProtKB=P97887	Presenilin-1	TAS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00005	Angiogenesis	P00239	Eph	MOUSE|MGI=MGI=102708|UniProtKB=P52795	Ephrin-B1	ISS			PTHR11304:SF17	EPHRIN-B1
P00018	EGF receptor signaling pathway	P00554	Shc	HUMAN|HGNC=29869|UniProtKB=P98077	SHC-transforming protein 2	ISS	10749680	PubMed	PTHR10337:SF5	SHC-TRANSFORMING PROTEIN 2
P00023	General transcription regulation	P00658	TBP-associated factors	DANRE|ZFIN=ZDB-GENE-040426-1013|UniProtKB=Q6P0T2	Transcription initiation factor TFIID subunit 8	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	XENTR|Xenbase=XB-GENE-5801166|UniProtKB=F6ZE26	Uncharacterized protein	ISS	10476970	PubMed	PTHR24070:SF382	RAS-RELATED PROTEIN RAP-1B
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00059	p53 pathway	G01575	GADD45	BOVIN|Ensembl=ENSBTAG00000013860|UniProtKB=Q3ZBN6	Growth arrest and DNA damage-inducible protein GADD45 alpha	ISS	9827804	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P00018	EGF receptor signaling pathway	P00539	14-3-3	BOVIN|Gene=YWHAG|UniProtKB=P68252	14-3-3 protein gamma	ISS	99360936	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IDA	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	PANTR|Gene=CHRNA4|UniProtKB=Q5IS77	Neuronal acetylcholine receptor subunit alpha-4	ISS	85270494	PubMed	PTHR18945:SF401	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	HUMAN|HGNC=4584|UniProtKB=Q05586	Glutamate receptor ionotropic, NMDA 1	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04393	Ras Pathway	P04556	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00060	Ubiquitin proteasome pathway	P01490	E3	ARATH|TAIR=AT5G41340|UniProtKB=P42748	Ubiquitin-conjugating enzyme E2 4	ISS			PTHR43946:SF2	UBIQUITIN-CONJUGATING ENZYME E2 H
P00036	Interleukin signaling pathway	P00983	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	TAS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	PANTR|Ensembl=ENSPTRG00000008769|UniProtKB=H2R9J3	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF681	MYOSIN-4
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	CHICK|Gene=PSEN2|UniProtKB=Q90X07	Presenilin-2	IDA	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00018	EGF receptor signaling pathway	P00556	PLCgamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IGI	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DROME|FlyBase=FBgn0000043|UniProtKB=P02572	Actin-42A	ISS	14684598	PubMed	PTHR11937:SF369	ACTIN-42A
P00005	Angiogenesis	P00236	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MOUSE|MGI=MGI=88232|UniProtKB=P30993	C5a anaphylatoxin chemotactic receptor 1	IDA	12461081	PubMed	PTHR24225:SF29	C5A ANAPHYLATOXIN CHEMOTACTIC RECEPTOR 1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DROME|FlyBase=FBgn0027493|UniProtKB=Q9Y0Y2	Adenylosuccinate synthetase	IEP	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04657	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00007	Axon guidance mediated by semaphorins	P00337	Sema3A	MONDO|Ensembl=ENSMODG00000016983|UniProtKB=F6Q9V8	Uncharacterized protein	ISS	8402908	PubMed	PTHR11036:SF23	SEMAPHORIN-3A
P02775	Salvage pyrimidine ribonucleotides	P03149	Cytidine kinase	BACSU|EnsemblGenome=BSU27330|UniProtKB=O32033	Uridine kinase	ISS			PTHR10285:SF6	ATP-DEPENDENT KINASE TDA10-RELATED
P02751	Lysine biosynthesis	P03008	Dihydrodipicolinate synthase	ECOLI|EcoGene=EG13344|UniProtKB=P75682	Probable 2-keto-3-deoxy-galactonate aldolase YagE	ISS			PTHR12128:SF28	2-KETO-3-DEOXY-GALACTONATE ALDOLASE YAGE-RELATED
P00036	Interleukin signaling pathway	P00993	p21CIP1	MOUSE|MGI=MGI=104556|UniProtKB=P39689	Cyclin-dependent kinase inhibitor 1	ISS	7774811	PubMed	PTHR10265:SF16	CYCLIN-DEPENDENT KINASE INHIBITOR 1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01161	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CANLF|Ensembl=ENSCAFG00000011689|UniProtKB=E2QZY2	Uncharacterized protein	ISS	12093103	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00057	Wnt signaling pathway	P01457	GBeta	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	TAS	2837282	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	RCA	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	CHICK|Gene=PSEN2|UniProtKB=Q90X07	Presenilin-2	TAS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00717	Phosphorylase b	BOVIN|Ensembl=ENSBTAG00000011494|UniProtKB=Q0VCM4	Glycogen phosphorylase, liver form	ISS	4318782	PubMed	PTHR11468:SF12	GLYCOGEN PHOSPHORYLASE, LIVER FORM
P00016	Cytoskeletal regulation by Rho GTPase	P00507	Rho	ASHGO|EnsemblGenome=AGOS_ABR183W|UniProtKB=Q9HF54	GTP-binding protein RHO1	ISS	11973360	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00021	FGF signaling pathway	P00628	JNK1-3	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IGI	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	RAT|RGD=1359694|UniProtKB=P62836	Ras-related protein Rap-1A	ISS	1904317	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00045	Notch signaling pathway	P01119	NIct	CANLF|Ensembl=ENSCAFG00000010476|UniProtKB=F1PS94	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	PANTR|Ensembl=ENSPTRG00000017238|UniProtKB=H2QRH7	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01284	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00059	p53 pathway	P04630	PP2A	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00011	Blood coagulation	P00404	PAR-1	MACMU|Ensembl=ENSMMUG00000021352|UniProtKB=F7DGR5	Uncharacterized protein	ISS	3024720	gi	PTHR24232:SF20	PROTEINASE-ACTIVATED RECEPTOR 1
P00001	Adrenaline and noradrenaline biosynthesis	P00067	MAO	RAT|RGD=61898|UniProtKB=P21396	Amine oxidase [flavin-containing] A	ISS	90344230	PubMed	PTHR43563:SF3	AMINE OXIDASE  FLAVIN-CONTAINING  A
P00046	Oxidative stress response	P01135	p38	DROME|FlyBase=FBgn0024846|UniProtKB=O61443	Mitogen-activated protein kinase 14B	TAS	11707292	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000010392|UniProtKB=F7ASR8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04396	Vitamin D metabolism and pathway	P04608	24-Hydroxylase	MACMU|Ensembl=ENSMMUG00000014860|UniProtKB=F6U4F6	Uncharacterized protein	ISS	11686044	PubMed	PTHR24291:SF5	1,25-DIHYDROXYVITAMIN D 3  24-HYDROXYLASE, MITOCHONDRIAL
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	MACMU|Gene=IL2RA|UniProtKB=Q5MNY4	Interleukin-2 receptor subunit alpha	ISS	6096720	PubMed	PTHR10573:SF0	INTERLEUKIN-2 RECEPTOR SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	BOVIN|Ensembl=ENSBTAG00000010576|UniProtKB=A4IFH7	MAP2K3 protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00796	Kainate receptor	PANTR|Gene=GRIK4|UniProtKB=Q5IS46	Glutamate receptor ionotropic, kainate 4	ISS	12941441	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00006	Apoptosis signaling pathway	P00260	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01148	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	11384839	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00010	B cell activation	P00381	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00635	FRS2	CANLF|Ensembl=ENSCAFG00000000431|UniProtKB=E2QSI0	Uncharacterized protein	ISS	10464310	PubMed	PTHR21258:SF40	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2
P00005	Angiogenesis	P00256	PLC-gamma	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00018	EGF receptor signaling pathway	P00557	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IDA	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00012	Cadherin signaling pathway	P00471	Cadherin	CANLF|Ensembl=ENSCAFG00000011398|UniProtKB=E2QX22	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF272	CADHERIN-24
P00029	Huntington disease	P00775	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00015	Circadian clock system	P00502	Casein kinase I	DROME|FlyBase=FBgn0002413|UniProtKB=O76324	Discs overgrown protein kinase	IDA	11955435	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02920	dCTP deaminase	METAC|EnsemblGenome=MA_3407|UniProtKB=Q8TKJ8	Cytidine/deoxycytidylate deaminase family protein	ISS			PTHR44192:SF2	SUBFAMILY NOT NAMED
P00035	Interferon-gamma signaling pathway	P00954	Interferongamma	RAT|RGD=2866|UniProtKB=P01581	Interferon gamma	TAS	11929133	PubMed	PTHR11419:SF0	INTERFERON GAMMA
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00034	Integrin signalling pathway	P00920	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05918	p38 MAPK pathway	P06031	p38alpha	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	RCA	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00206	Wnt	BOVIN|Ensembl=ENSBTAG00000001668|UniProtKB=F1N6L8	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IDA	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P05917	Opioid proopiomelanocortin pathway	P06004	Mu or Delta receptor	RAT|RGD=3233|UniProtKB=P33533	Delta-type opioid receptor	RCA	11259487	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00560	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BOVIN|Ensembl=ENSBTAG00000005714|UniProtKB=Q3ZC07	Actin, alpha cardiac muscle 1	ISS	3487386	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00005	Angiogenesis	P00221	JNK1	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	ISS	10514528	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	ARATH|TAIR=AT3G19420|UniProtKB=Q9LT75	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN2A	ISS			PTHR12305:SF32	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE TPTE2-RELATED
P00029	Huntington disease	P00780	Microtubule	CAEEL|WormBase=WBGene00006538|UniProtKB=P41937	Tubulin beta-4 chain	IDA	9454836	PubMed	PTHR11588:SF89	TUBULIN BETA-4 CHAIN
P00021	FGF signaling pathway	P00642	MEK1-2	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04398	p53 pathway feedback loops 2	G04715	CYCLIN G	RAT|RGD=2295|UniProtKB=P39950	Cyclin-G1	ISS	11983168	PubMed	PTHR10177:SF59	CYCLIN-G1
P00053	T cell activation	P01331	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000024633|UniProtKB=F1MBU9	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	DANRE|ZFIN=ZDB-GENE-030131-6665|UniProtKB=Q75XT1	Acetylcholine receptor delta subunit	ISS	85203892	PubMed	PTHR18945:SF61	ACETYLCHOLINE RECEPTOR SUBUNIT DELTA
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00048	PI3 kinase pathway	P01188	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000001187|UniProtKB=F6R8N9	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P04393	Ras Pathway	P04547	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00034	Integrin signalling pathway	P00916	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	87226391	PubMed	PTHR24070:SF385	GTPASE HRAS
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	HUMAN|HGNC=7883|UniProtKB=Q9UM47	Neurogenic locus notch homolog protein 3	IDA	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MOUSE|MGI=MGI=1309999|UniProtKB=Q922R0	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	RAT|RGD=628837|UniProtKB=P60711	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00025	Hedgehog signaling pathway	P00682	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	PANTR|Ensembl=ENSPTRG00000014771|UniProtKB=H2RCA7	Uncharacterized protein	ISS	11960641	PubMed	PTHR10489:SF637	CX3C CHEMOKINE RECEPTOR 1
P00005	Angiogenesis	P00223	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01465	Ggamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00057	Wnt signaling pathway	P01455	Smad4	CANLF|Ensembl=ENSCAFG00000001094|UniProtKB=E2RCX7	Mothers against decapentaplegic homolog	ISS	12736218	PubMed	PTHR13703:SF36	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00029	Huntington disease	P00777	CBP	PANTR|Ensembl=ENSPTRG00000014418|UniProtKB=H2QLS0	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000017338|UniProtKB=H2QRN3	Protocadherin beta-17	ISS	8120095	PubMed	PTHR24028:SF71	PROTOCADHERIN BETA-16
P00053	T cell activation	P01336	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02738	De novo purine biosynthesis	P02889	dGDP kinase	CAEEL|WormBase=WBGene00009119|UniProtKB=Q93576	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	CHICK|Ensembl=ENSGALG00000013981|UniProtKB=Q9YGV8	TATA box-binding protein-like protein 1	ISS	600075	OMIM	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00057	Wnt signaling pathway	P01435	SWI/SNF	DANRE|ZFIN=ZDB-GENE-030131-1835|UniProtKB=Q802C8	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	ISS	11532957	PubMed	PTHR13844:SF1	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D MEMBER 1
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	HUMAN|HGNC=8590|UniProtKB=Q13153	Serine/threonine-protein kinase PAK 1	ISS	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00014	Cholesterol biosynthesis	P00491	Hydroxymethyl glutaryl CoA reductase	PANTR|Ensembl=ENSPTRG00000016994|UniProtKB=H2QR35	3-hydroxy-3-methylglutaryl coenzyme A reductase	ISS	P09610	SPACC	PTHR10572:SF2	3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE
P00010	B cell activation	P00381	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00310	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04578	Rho	BOVIN|Ensembl=ENSBTAG00000004279|UniProtKB=P61585	Transforming protein RhoA	ISS	12039949	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00924	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CANLF|Ensembl=ENSCAFG00000003197|UniProtKB=E2QXY7	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-7595|UniProtKB=Q6PBR4	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00271	Bax	MACMU|Ensembl=ENSMMUG00000003907|UniProtKB=F6ZV96	Apoptosis regulator BAX isoform alpha	ISS	14963330	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02784	Tyrosine biosynthesis	P03212	Chorismate mutase	ARATH|TAIR=AT5G10870|UniProtKB=Q9S7H4	Chorismate mutase 2	ISS			PTHR21145:SF1	CHORISMATE MUTASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CANLF|Ensembl=ENSCAFG00000000332|UniProtKB=F1P8E3	Uncharacterized protein	ISS	11431030	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00029	Huntington disease	P00807	Actin	MACMU|Ensembl=ENSMMUG00000007027|UniProtKB=F7F210	Alpha-cardiac actin	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	DICDI|dictyBase=DDB_G0272110|UniProtKB=P51136	Glycogen synthase kinase-3	IDA	7529201	PubMed	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00006	Apoptosis signaling pathway	P00260	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	RAT|RGD=69346|UniProtKB=G3V7U3	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P04393	Ras Pathway	P04547	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P05731	GABA-B receptor II signaling	P05754	Ggamma	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	RCA	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00023	General transcription regulation	P00660	RNA Polymerase II	TAKRU|Ensembl=ENSTRUG00000007619|UniProtKB=H2T2K8	Uncharacterized protein	ISS	606023	OMIM	PTHR10917:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3
P02741	Flavin biosynthesis	P02934	Riboflavin kinase	CAEEL|WormBase=WBGene00011224|UniProtKB=Q21918	Uncharacterized protein	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	MOUSE|MGI=MGI=99460|UniProtKB=Q61982	Neurogenic locus notch homolog protein 3	IDA	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00057	Wnt signaling pathway	P01457	GBeta	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00079	alpha7 nicotinic acetylcholine receptor	PANTR|Ensembl=ENSPTRG00000006865|UniProtKB=H2Q930	Uncharacterized protein	ISS			PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	RAT|RGD=61801|UniProtKB=P30994	5-hydroxytryptamine receptor 2B	ISS	8143856	PubMed	PTHR24247:SF31	5-HYDROXYTRYPTAMINE RECEPTOR 2B
P00060	Ubiquitin proteasome pathway	P01492	E1	MOUSE|MGI=MGI=1921494|UniProtKB=Q9D906	Ubiquitin-like modifier-activating enzyme ATG7	ISS			PTHR10953:SF3	UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00034	Integrin signalling pathway	P00914	Filamin	MOUSE|MGI=MGI=95556|UniProtKB=Q8BTM8	Filamin-A	ISS	11911837	PubMed	PTHR43998:SF6	FILAMIN-A
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00729	Goalpha	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00322	Cytochrome C	MACMU|Ensembl=ENSMMUG00000030295|UniProtKB=P00002	Cytochrome c	ISS	4954366	PubMed	PTHR11961:SF15	CYTOCHROME C
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00736	CalDAG-GEF	MOUSE|MGI=MGI=1333849|UniProtKB=Q9QUG9	RAS guanyl-releasing protein 2	IDA	10835426	PubMed	PTHR23113:SF16	RAS GUANYL-RELEASING PROTEIN 2
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=1303000|UniProtKB=Q75NI5	Cadherin 15	ISS	8120095	PubMed	PTHR24027:SF300	CADHERIN-15
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	3045562	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00018	EGF receptor signaling pathway	P00543	ERK1-2	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00005	Angiogenesis	P00249	PAK	PANTR|Ensembl=ENSPTRG00000022187|UniProtKB=Q7YQL4	Serine/threonine-protein kinase PAK 3	ISS	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00005	Angiogenesis	P00201	FVIIa	MOUSE|MGI=MGI=109325|UniProtKB=P70375	Coagulation factor VII	ISS	2499859	gi	PTHR44064:SF1	COAGULATION FACTOR VII
P00055	Transcription regulation by bZIP transcription factor	P01395	TFIIE	DANRE|ZFIN=ZDB-GENE-041210-221|UniProtKB=Q5SQE1	Novel protein similar to vertebrate general transcription factor IIE polypeptide 1 alpha 56kDa (GTF2E1)	ISS			PTHR13097:SF7	NOVEL PROTEIN SIMILAR TO VERTEBRATE GENERAL TRANSCRIPTION FACTOR IIE POLYPEPTIDE 1 ALPHA 56KDA  GTF2E1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00034	Integrin signalling pathway	P00951	Jnk	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00036	Interleukin signaling pathway	P00981	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	PANTR|Ensembl=ENSPTRG00000001767|UniProtKB=G2HG81	Actin-related protein 2/3 complex subunit 5	ISS	12932731	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00057	Wnt signaling pathway	P01451	Galpha	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	MOUSE|MGI=MGI=99460|UniProtKB=Q61982	Neurogenic locus notch homolog protein 3	IDA	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00021	FGF signaling pathway	P00633	Ras	DANRE|ZFIN=ZDB-GENE-040808-67|UniProtKB=Q6AZA4	K-ras	ISS	20362513	PubMed	PTHR24070:SF186	GTPASE KRAS
P00053	T cell activation	P01336	Jnk	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	RAT|RGD=621321|UniProtKB=Q63357	Unconventional myosin-Id	IC			PTHR13140:SF417	UNCONVENTIONAL MYOSIN-ID
P00006	Apoptosis signaling pathway	P00268	GCK	CHICK|Ensembl=ENSGALG00000012321|UniProtKB=F1NAN8	Mitogen-activated protein kinase kinase kinase kinase	ISS			PTHR24361:SF324	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 5
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00029	Huntington disease	P00785	Cytochrome c	PSEAE|EnsemblGenome=PA4429|UniProtKB=Q9HVY6	Probable cytochrome c1	IDA	9027315	PubMed	PTHR10266:SF4	SUBFAMILY NOT NAMED
P02726	Aminobutyrate degradation	P02825	4-aminobutyrate aminotransferase	DROME|FlyBase=FBgn0036927|UniProtKB=Q9VW68	CG7433, isoform A	ISS	8133261	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01192	p110	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	IGI	1171954	gi	PTHR10048:SF14	PI-3 KINASE
P00018	EGF receptor signaling pathway	P00559	MEK1-2	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00059	p53 pathway	G01576	14-3-3	RAT|RGD=1359510|UniProtKB=Q5EBB0	Protein LOC298795	ISS	10407019	PubMed	PTHR18860:SF14	14-3-3 PROTEIN SIGMA
P00021	FGF signaling pathway	P00628	JNK1-3	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00036	Interleukin signaling pathway	P00990	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	PSEAE|EnsemblGenome=PA4073|UniProtKB=Q9HWV5	Probable aldehyde dehydrogenase	IC			PTHR11699:SF222	PHENYLACETALDEHYDE DEHYDROGENASE
P04378	Beta2 adrenergic receptor signaling pathway	P04440	Beta2	HUMAN|HGNC=286|UniProtKB=P07550	Beta-2 adrenergic receptor	ISS	12063255	PubMed	PTHR24248:SF21	BETA-2 ADRENERGIC RECEPTOR
P00029	Huntington disease	P00805	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P05913	Enkephalin release	P05974	G-Protein (i)	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	IC	11535291	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00018	EGF receptor signaling pathway	P00558	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	YEAST|SGD=S000005738|UniProtKB=P18851	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04397	p53 pathway by glucose deprivation	P04641	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	RAT|RGD=2626|UniProtKB=P12841	Proto-oncogene c-Fos	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	10074940	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00965	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00048	PI3 kinase pathway	P01206	14-3-3	CANLF|Ensembl=ENSCAFG00000000580|UniProtKB=F1PBL1	Uncharacterized protein	ISS	1499718	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	BOVIN|Ensembl=ENSBTAG00000014447|UniProtKB=A4IFF4	Ribosomal protein S6 kinase	ISS	2779569	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CAEBR|Gene=CBG07339|UniProtKB=A8X4Z4	Protein CBR-SYX-2	ISS			PTHR19957:SF113	SYNTAXIN-2-RELATED
P04395	Vasopressin synthesis	P04589	Signal Peptidase	CAEBR|Gene=CBG04194|UniProtKB=A8WWE1	Signal peptidase complex catalytic subunit SEC11	ISS	2092035	PubMed	PTHR10806:SF6	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BOVIN|Ensembl=ENSBTAG00000014614|UniProtKB=P62739	Actin, aortic smooth muscle	ISS	3487386	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00012	Cadherin signaling pathway	P00464	Fyn	BOVIN|Ensembl=ENSBTAG00000011851|UniProtKB=A0JNB0	Tyrosine-protein kinase Fyn	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00021	FGF signaling pathway	P00630	RKIP	CAEBR|Gene=CBG05964|UniProtKB=A8X180	Protein CBG05964	ISS			PTHR11362:SF44	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	TAKRU|Ensembl=ENSTRUG00000015959|UniProtKB=H2UV27	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00036	Interleukin signaling pathway	P00965	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01440	Cadherin	MONDO|Ensembl=ENSMODG00000004732|UniProtKB=F6Y191	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF322	CADHERIN-6
P00021	FGF signaling pathway	P00632	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00223	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MACMU|Ensembl=ENSMMUG00000006253|UniProtKB=F7H582	Uncharacterized protein	ISS	92409599	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	PANTR|Ensembl=ENSPTRG00000008260|UniProtKB=H2QBD7	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	ISS	12787506	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00209	FAK	CANLF|Ensembl=ENSCAFG00000001217|UniProtKB=E2RGP8	Uncharacterized protein (Fragment)	ISS	12640026	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	BOVIN|Ensembl=ENSBTAG00000019988|UniProtKB=F1N2V3	Uncharacterized protein	ISS	11359849	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P04396	Vitamin D metabolism and pathway	P04602	RXR	XENTR|Xenbase=XB-GENE-480836|UniProtKB=F6XQK9	Uncharacterized protein (Fragment)	ISS			PTHR24082:SF115	RETINOIC ACID RECEPTOR ALPHA
P00021	FGF signaling pathway	P00643	Raf-1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MACMU|Ensembl=ENSMMUG00000014597|UniProtKB=F6VAQ6	Glycogen synthase kinase-3 alpha	ISS	2164470	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00034	Integrin signalling pathway	P00951	Jnk	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8971|UniProtKB=O00443	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00018	EGF receptor signaling pathway	P00542	EGFR	MOUSE|MGI=MGI=95410|UniProtKB=P70424	Receptor tyrosine-protein kinase erbB-2	ISS	94193007	PubMed	PTHR24416:SF137	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2
P00012	Cadherin signaling pathway	P00470	F-actin	MACMU|Ensembl=ENSMMUG00000002263|UniProtKB=F6VEE0	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00034	Integrin signalling pathway	P00906	Rap1	CHICK|Ensembl=ENSGALG00000001476|UniProtKB=F1NSA8	Uncharacterized protein	ISS	10476970	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00010	B cell activation	P00375	Calmodulin	CANLF|Ensembl=ENSCAFG00000016335|UniProtKB=J9NXY2	Uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF322	SUBFAMILY NOT NAMED
P02783	Tryptophan biosynthesis	P03211	Phosphribosyl anthranilate isomerase	GLOVI|EnsemblGenome=BAC88695|UniProtKB=Q7NML1	N-(5'-phosphoribosyl)anthranilate isomerase	ISS			PTHR42894:SF1	N- 5'-PHOSPHORIBOSYL ANTHRANILATE ISOMERASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	IDA	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	TAKRU|Ensembl=ENSTRUG00000008289|UniProtKB=H2T7U8	Uncharacterized protein	ISS	15723050	PubMed	PTHR24072:SF129	CDC42L PROTEIN
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00648	PKC	YEAST|SGD=S000000201|UniProtKB=P24583	Protein kinase C-like 1	IGI	90322419	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04393	Ras Pathway	P04546	GSK3	MACMU|Ensembl=ENSMMUG00000014597|UniProtKB=F6VAQ6	Glycogen synthase kinase-3 alpha	ISS	183955	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000017343|UniProtKB=Q5DRD3	Protocadherin beta-15	ISS	8120095	PubMed	PTHR24028:SF97	PROTOCADHERIN BETA-15
P00036	Interleukin signaling pathway	P00965	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00543	ERK1-2	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00624	14-3-3	MOUSE|MGI=MGI=108109|UniProtKB=P61982	14-3-3 protein gamma	ISS	10407019	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	CAEEL|WormBase=WBGene00001604|UniProtKB=Q9U307	Glutamine synthetase	ISS			PTHR20852:SF64	GLUTAMINE SYNTHETASE
P00059	p53 pathway	P01480	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	HUMAN|HGNC=6091|UniProtKB=P06213	Insulin receptor	ISS	2983222	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00051	TCA cycle	P01274	Succinyl CoA Synthetase	PANTR|Ensembl=ENSPTRG00000012121|UniProtKB=H2QI84	Uncharacterized protein	ISS	97407896	PubMed	PTHR11117:SF2	SUCCINYL-COA LIGASE  ADP/GDP-FORMING  SUBUNIT ALPHA, MITOCHONDRIAL
P00052	TGF-beta signaling pathway	P01275	P38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	TAS	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00049	Parkinson disease	P01221	Torsin A	PANTR|Ensembl=ENSPTRG00000021396|UniProtKB=H2QXX6	Torsin family 2, member A	ISS	12421356	PubMed	PTHR10760:SF4	TORSIN-2A
P00006	Apoptosis signaling pathway	P00264	c-IAP1,2	DANRE|ZFIN=ZDB-GENE-030825-6|UniProtKB=Q7T0K2	Inhibitor of apoptosis protein	ISS			PTHR10044:SF79	BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 2
P00005	Angiogenesis	P00206	Wnt	XENTR|Xenbase=XB-GENE-480396|UniProtKB=F7DI28	Protein Wnt (Fragment)	ISS	8717036	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04623	CBP	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00059	p53 pathway	P04609	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	IDA	12736250	PubMed	PTHR10202:SF18	PRESENILIN-1
P00020	FAS signaling pathway	P00617	FasL	MACMU|Gene=FASLG|UniProtKB=P63307	Tumor necrosis factor ligand superfamily member 6	ISS	12787569	PubMed	PTHR11471:SF33	TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 6
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	SULSO|EnsemblGenome=SSO0446|UniProtKB=P58111	Transcription initiation factor IIB 1	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P04398	p53 pathway feedback loops 2	P04664	cyclin E	RAT|RGD=2294|UniProtKB=P39949	G1/S-specific cyclin-E1	NAS	6671698	gi	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00018	EGF receptor signaling pathway	G01511	SPRY	PANTR|Ensembl=ENSPTRG00000017360|UniProtKB=H2QRP3	Uncharacterized protein	ISS	22024232	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01286	TGFbeta	PANTR|Ensembl=ENSPTRG00000012738|UniProtKB=A1C2V0	Growth/differentiation factor 8	ISS	9759503	PubMed	PTHR11848:SF150	GROWTH/DIFFERENTIATION FACTOR 8
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	HUMAN|HGNC=4581|UniProtKB=Q13003	Glutamate receptor ionotropic, kainate 3	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P05734	Synaptic vesicle trafficking	P05779	Synaptobrevin	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	RCA	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00037	Ionotropic glutamate receptor pathway	P01026	KA	PANTR|Gene=GRIK4|UniProtKB=Q5IS46	Glutamate receptor ionotropic, kainate 4	ISS	1648176	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	TAS	15572354	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00045	Notch signaling pathway	P01116	Delta	DROME|FlyBase=FBgn0000463|UniProtKB=P10041	Neurogenic locus protein delta	TAS	7728498	PubMed	PTHR24044:SF320	DELTA-LIKE PROTEIN 4
P00021	FGF signaling pathway	P00627	ERK1-2	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	IGI	10514528	PubMed	PTHR24055:SF330	SUBFAMILY NOT NAMED
P00059	p53 pathway	P04630	PP2A	PANTR|Ensembl=ENSPTRG00000017238|UniProtKB=H2QRH7	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	HUMAN|HGNC=1076|UniProtKB=P36894	Bone morphogenetic protein receptor type-1A	TAS	10683140	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P00029	Huntington disease	P00807	Actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	ISS	11889126	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MOUSE|MGI=MGI=3648102|UniProtKB=E9Q2K4	Actin-related protein 2/3 complex subunit 5	TAS	12932731	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00057	Wnt signaling pathway	P01465	Ggamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000002603|UniProtKB=H2RC60	Uncharacterized protein	ISS	8120095	PubMed	PTHR43956:SF3	CADHERIN-23
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	PANTR|Ensembl=ENSPTRG00000007084|UniProtKB=H2Q9G5	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00225	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	RCA			PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00022	General transcription by RNA polymerase I	P00652	RNA Polymerase I  Complex	HUMAN|HGNC=9198|UniProtKB=P53803	DNA-directed RNA polymerases I, II, and III subunit RPABC4	IGI	12634356	PubMed	PTHR12056:SF2	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC4
P00053	T cell activation	P01322	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04651	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P04397	p53 pathway by glucose deprivation	P04641	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	IDA	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	CHICK|Ensembl=ENSGALG00000000991|UniProtKB=Q5ZKX3	Uncharacterized protein	ISS			PTHR12264:SF21	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02738	De novo purine biosynthesis	P02909	GDP reductase	CHICK|Ensembl=ENSGALG00000017350|UniProtKB=E1C4Q0	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CHICK|Ensembl=ENSGALG00000000839|UniProtKB=P49339	Protein Wnt-11	TAS	11266476	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00029	Huntington disease	P00810	GAPDH	CANLF|Ensembl=ENSCAFG00000007743|UniProtKB=E2R8R0	Uncharacterized protein	ISS	8612237	PubMed	PTHR10836:SF51	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	MOUSE|MGI=MGI=95821|UniProtKB=Q01097	Glutamate receptor ionotropic, NMDA 2B	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00053	T cell activation	P01315	Calcineurin	PANTR|Ensembl=ENSPTRG00000002631|UniProtKB=H2Q237	Serine/threonine-protein phosphatase	ISS	12091710	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00807	Actin	ARATH|TAIR=AT5G09810|UniProtKB=P53492	Actin-7	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00048	PI3 kinase pathway	P01190	PDK1 ACT	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	11256888	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00021	FGF signaling pathway	P00639	Shc	MACMU|Ensembl=ENSMMUG00000020357|UniProtKB=F6W915	SHC-transforming protein 3	ISS	96404502	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	MOUSE|MGI=MGI=87940|UniProtKB=Q99MK8	Beta-adrenergic receptor kinase 1	IDA	10085131	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P00049	Parkinson disease	P01219	SAPK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	NAS	10851062	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	CHICK|Ensembl=ENSGALG00000001183|UniProtKB=Q789A6	Nonmuscle myosin heavy chain	ISS	89264452	PubMed	PTHR13140:SF328	MYOSIN-10
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	TAKRU|Ensembl=ENSTRUG00000011517|UniProtKB=H2TWL9	Uncharacterized protein (Fragment)	ISS	12871085	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00021	FGF signaling pathway	P00629	PP2A	HUMAN|HGNC=9309|UniProtKB=Q15172	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform	IPI	12110603	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000005903|UniProtKB=F1N1K8	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04397	p53 pathway by glucose deprivation	P04645	TSC1	HUMAN|HGNC=12362|UniProtKB=Q92574	Hamartin	IDA	12167664	PubMed	PTHR15154:SF2	HAMARTIN
P06587	Nicotine pharmacodynamics pathway	P06595	CHRNA3	MOUSE|MGI=MGI=87887|UniProtKB=Q8R4G9	Neuronal acetylcholine receptor subunit alpha-3	ISS	85270494	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P04393	Ras Pathway	P04572	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	RAT|RGD=2626|UniProtKB=P12841	Proto-oncogene c-Fos	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	MOUSE|MGI=MGI=2384309|UniProtKB=Q923G2	DNA-directed RNA polymerases I, II, and III subunit RPABC3	ISS	606023	OMIM	PTHR10917:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3
P00018	EGF receptor signaling pathway	P00559	MEK1-2	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	ARATH|TAIR=AT5G07440|UniProtKB=Q38946	Glutamate dehydrogenase 2	ISS			PTHR11606:SF24	GLUTAMATE DEHYDROGENASE 2
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04398	p53 pathway feedback loops 2	P04657	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00059	p53 pathway	P04609	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01179	PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01134	cPLA2	PANTR|Ensembl=ENSPTRG00000001787|UniProtKB=H2Q0T0	Phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00019	Endothelin signaling pathway	P00570	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00009	Axon guidance mediated by netrin	P00356	UNC-5	CAEEL|WormBase=WBGene00006745|UniProtKB=Q26261	Netrin receptor unc-5	IDA	1384987	PubMed	PTHR12582:SF45	NETRIN RECEPTOR UNC-5
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00030	Hypoxia response via HIF activation	P00819	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	TAS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000002693|UniProtKB=H2R3N8	Uncharacterized protein	ISS	8120095	PubMed	PTHR44506:SF1	CADHERIN-RELATED FAMILY MEMBER 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	ISS	9620264	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00010	B cell activation	P00381	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	PANTR|Ensembl=ENSPTRG00000010931|UniProtKB=H2R650	Uncharacterized protein	ISS	15858232	PubMed	PTHR13715:SF15	RYANODINE RECEPTOR 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MACMU|Ensembl=ENSMMUG00000011858|UniProtKB=F7H4M7	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF139	BONE MORPHOGENETIC PROTEIN 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MOUSE|MGI=MGI=95770|UniProtKB=P30678	Guanine nucleotide-binding protein subunit alpha-15	IDA	10629036	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P00056	VEGF signaling pathway	P01410	Caspase9	PANTR|Ensembl=ENSPTRG00000000200|UniProtKB=H2PY35	Caspase	ISS	9390557	PubMed	PTHR10454:SF157	CASPASE-9
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000003043|UniProtKB=P63212	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	PRIPA|Gene=PPA17339|UniProtKB=H3F5B4	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF352	ACTIN
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	MOUSE|MGI=MGI=97512|UniProtKB=P21661	Neuroendocrine convertase 2	IDA			PTHR42884:SF13	NEUROENDOCRINE CONVERTASE 2
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IGI	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00005	Angiogenesis	P00184	Src	MONDO|Ensembl=ENSMODG00000000247|UniProtKB=F6WR53	Tyrosine-protein kinase	ISS	8054685	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P04393	Ras Pathway	P04579	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	95096035	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	MOUSE|MGI=MGI=97513|UniProtKB=P23188	Furin	IDA	95328031	PubMed	PTHR42884:SF1	FURIN
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	10891487	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IDA	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05730	Endogenous cannabinoid signaling	P05748	mGluR	HUMAN|HGNC=4593|UniProtKB=Q13255	Metabotropic glutamate receptor 1	ISS	9407094	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	RAT|RGD=2740|UniProtKB=Q62645	Glutamate receptor ionotropic, NMDA 2D	IC	11554549	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00053	T cell activation	P01318	PKC-theta	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IGI	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00899	IRS 1-4	XENTR|Xenbase=XB-GENE-479893|UniProtKB=F6YCQ0	Uncharacterized protein	ISS	5031805	gi	PTHR10614:SF2	INSULIN RECEPTOR SUBSTRATE 4
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	DROME|FlyBase=FBgn0000064|UniProtKB=P07764	Fructose-bisphosphate aldolase	NAS	2133662	gi	PTHR11627:SF20	FRUCTOSE-BISPHOSPHATE ALDOLASE
P00029	Huntington disease	P00777	CBP	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	IDA	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00006	Apoptosis signaling pathway	P00273	p53	BOVIN|Ensembl=ENSBTAG00000001069|UniProtKB=P67939	Cellular tumor antigen p53	ISS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00047	PDGF signaling pathway	P01153	GSK3	BOVIN|Ensembl=ENSBTAG00000020756|UniProtKB=A6QLB8	GSK3A protein	ISS	21361340	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	RAT|RGD=1303282|UniProtKB=Q6MG89	Notch homolog 4, [Drosophila]	ISS	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P00029	Huntington disease	P00780	Microtubule	MACMU|Ensembl=ENSMMUG00000012164|UniProtKB=F7GW57	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00010	B cell activation	P00383	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00054	Toll receptor signaling pathway	P01367	MKK3	CANLF|Ensembl=ENSCAFG00000018530|UniProtKB=F1PXD3	Uncharacterized protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P02746	Heme biosynthesis	P02982	Protoheme IX farnesyl transferase	MYCTU|EnsemblGenome=Rv1451|UniProtKB=P9WFR7	Protoheme IX farnesyltransferase	ISS			PTHR43448:SF2	PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL
P00005	Angiogenesis	P00211	GSK3beta	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05913	Enkephalin release	P05973	GPCR (i)	PANTR|Ensembl=ENSPTRG00000000440|UniProtKB=H2PYH8	Uncharacterized protein	ISS	11259498	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00053	T cell activation	P01311	Raf	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00048	PI3 kinase pathway	P01192	p110	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00237	FRP	CANLF|Ensembl=ENSCAFG00000008293|UniProtKB=E2R9M9	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF22	FRIZZLED-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TAKRU|Ensembl=ENSTRUG00000004787|UniProtKB=P53480	Actin, alpha cardiac	IC	10974003	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00012	Cadherin signaling pathway	P00477	GSK3beta	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	IDA	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00182	p38MAPK	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	ISS	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	CAEEL|WormBase=WBGene00001680|UniProtKB=Q20636	Guanine nucleotide-binding protein subunit beta-2	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CAEEL|WormBase=WBGene00006372|UniProtKB=Q20574	Putative syntaxin-2	IC			PTHR19957:SF113	SYNTAXIN-2-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	BOVIN|Ensembl=ENSBTAG00000018253|UniProtKB=P02709	Acetylcholine receptor subunit alpha	IC	85270494	PubMed	PTHR18945:SF74	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01286	TGFbeta	ORNAN|Ensembl=ENSOANG00000009254|UniProtKB=F7EZU0	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF135	BONE MORPHOGENETIC PROTEIN 7
P05730	Endogenous cannabinoid signaling	P05748	mGluR	MACMU|Ensembl=ENSMMUG00000016428|UniProtKB=F7GU00	Metabotropic glutamate receptor 1 isoform alpha	ISS	9407094	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IC	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00029	Huntington disease	P00807	Actin	XENTR|Xenbase=XB-GENE-6469705|UniProtKB=Q6P8G3	Actin, alpha sarcomeric/skeletal	ISS	10974003	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	LEIMA|EnsemblGenome=LmjF.18.1080|UniProtKB=Q27687	Protein kinase A catalytic subunit	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00005	Angiogenesis	P00199	JNKK1	MONDO|Ensembl=ENSMODG00000008266|UniProtKB=F6Z879	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=108071|UniProtKB=P70701	Protein Wnt-10a	TAS	8717036	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P06587	Nicotine pharmacodynamics pathway	P06594	CHRNA4	PANTR|Gene=CHRNA4|UniProtKB=Q5IS77	Neuronal acetylcholine receptor subunit alpha-4	ISS	17597586	PubMed	PTHR18945:SF401	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MOUSE|MGI=MGI=95815|UniProtKB=P39087	Glutamate receptor ionotropic, kainate 2	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	ISS	2372396	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00562	p38	CAEEL|WormBase=WBGene00004055|UniProtKB=Q17446	Mitogen-activated protein kinase pmk-1	IGI	22138445	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	12707323	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00059	p53 pathway	P04623	CBP	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00052	TGF-beta signaling pathway	P01275	P38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	CANLF|Ensembl=ENSCAFG00000006946|UniProtKB=E2RHZ1	Uncharacterized protein	ISS	10806215	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00046	Oxidative stress response	P01131	MKP5	RAT|RGD=620625|UniProtKB=Q62767	Dual specificity protein phosphatase 4	TAS			PTHR10159:SF111	DUAL SPECIFICITY PROTEIN PHOSPHATASE 4
P00003	Alzheimer disease-amyloid secretase pathway	P00091	Aph-1	CANLF|Ensembl=ENSCAFG00000011777|UniProtKB=E2R5H5	Anterior pharynx defective 1 homolog A	ISS	12471034	PubMed	PTHR12889:SF3	GAMMA-SECRETASE SUBUNIT APH-1A
P00018	EGF receptor signaling pathway	P00552	Ras	DICDI|dictyBase=DDB_G0283537|UniProtKB=P32254	Ras-like protein rasS	IGI	8290260	PubMed	PTHR24070:SF380	RAS-LIKE PROTEIN RASS
P00010	B cell activation	P00402	Jnk	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00030	Hypoxia response via HIF activation	P00816	VHL	MOUSE|MGI=MGI=103223|UniProtKB=P40338	Von Hippel-Lindau disease tumor suppressor	ISS	14526383	PubMed	PTHR15160:SF1	VON HIPPEL-LINDAU DISEASE TUMOR SUPPRESSOR-RELATED
P00029	Huntington disease	P00786	ARF	IXOSC|EnsemblGenome=ISCW022927|UniProtKB=B7QCW2	ADP-ribosylation factor	ISS	11752622	PubMed	PTHR11711:SF304	ADP-RIBOSYLATION FACTOR 1
P02743	Formyltetrahydroformate biosynthesis	P02958	Dihydrofolate synthase	STRCO|Gene=CAB75395|UniProtKB=Q9L1G4	Folylpolyglutamate synthase	ISS			PTHR11136:SF0	DIHYDROFOLATE SYNTHETASE-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00875	GEF	RAT|RGD=620398|UniProtKB=P63035	Cytohesin-2	ISS	11747824	PubMed	PTHR43935:SF4	CYTOHESIN-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	CHICK|Ensembl=ENSGALG00000026748|UniProtKB=F1P493	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF728	MYOSIN HEAVY CHAIN, SKELETAL MUSCLE, ADULT
P05918	p38 MAPK pathway	P06020	p38delta	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	RCA	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	CANLF|Ensembl=ENSCAFG00000010871|UniProtKB=F1PXA0	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00006	Apoptosis signaling pathway	P00293	PKR	MOUSE|MGI=MGI=1353449|UniProtKB=Q03963	Interferon-induced, double-stranded RNA-activated protein kinase	IDA	10557102	PubMed	PTHR11042:SF102	INTERFERON-INDUCED, DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	BOVIN|Ensembl=ENSBTAG00000012927|UniProtKB=A6QLL8	Fructose-bisphosphate aldolase	ISS	74094688	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P02723	Adenine and hypoxanthine salvage pathway	P02812	Deoxyinosine phosphorylase	PANTR|Ensembl=ENSPTRG00000006095|UniProtKB=H2Q7W4	Purine nucleoside phosphorylase	ISS			PTHR11904:SF12	PURINE NUCLEOSIDE PHOSPHORYLASE
P00049	Parkinson disease	P01227	20S proteasome	ORYSJ|EnsemblGenome=OS11G0615700|UniProtKB=Q9LSU1	Proteasome subunit alpha type-5	ISS	12859888	PubMed	PTHR11599:SF14	PROTEASOME SUBUNIT ALPHA TYPE-5
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	PANTR|Ensembl=ENSPTRG00000005197|UniProtKB=A5A6J7	Ras-related protein Rap-1b	ISS	10476970	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P06959	CCKR signaling map	P07040	RGS2	HUMAN|HGNC=9998|UniProtKB=P41220	Regulator of G-protein signaling 2	RCA	19940064	PubMed	PTHR10845:SF43	REGULATOR OF G-PROTEIN SIGNALING 2
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P05734	Synaptic vesicle trafficking	P05774	NSF	DROME|FlyBase=FBgn0000346|UniProtKB=P46461	Vesicle-fusing ATPase 1	TAS	7969419	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00036	Interleukin signaling pathway	P00964	p90RSK	PANTR|Ensembl=ENSPTRG00000000387|UniProtKB=H2PYE3	Ribosomal protein S6 kinase	ISS	2779569	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00047	PDGF signaling pathway	P01150	PKC	CANAL|CGD=CAL0003231|UniProtKB=Q5ANK2	Protein kinase C	ISS	96408767	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00047	PDGF signaling pathway	P01154	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P04397	p53 pathway by glucose deprivation	P04641	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	MOUSE|MGI=MGI=102522|UniProtKB=Q8R3Z5	Voltage-dependent L-type calcium channel subunit beta-1	IC	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00551	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	IGI	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	RAT|RGD=619783|UniProtKB=Q9QX01	Short transient receptor potential channel 1	IDA	11055438	PubMed	PTHR10117:SF56	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 1
P00047	PDGF signaling pathway	P01160	IP3 receptor	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00046	Oxidative stress response	P01129	JNK1/2	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00060	Ubiquitin proteasome pathway	P01491	E2	XENTR|Xenbase=XB-GENE-970758|UniProtKB=F6W7B6	Uncharacterized protein (Fragment)	ISS	10888878	PubMed	PTHR24068:SF116	AT26201P-RELATED
P00018	EGF receptor signaling pathway	P00547	PP2A	TAKRU|Ensembl=ENSTRUG00000011169|UniProtKB=H2TU36	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00641	SOS	DROME|FlyBase=FBgn0001965|UniProtKB=P26675	Protein son of sevenless	ISS	8479536	PubMed	PTHR23113:SF99	PROTEIN SON OF SEVENLESS
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DANRE|ZFIN=ZDB-GENE-000329-1|UniProtKB=Q7ZVI7	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MOUSE|MGI=MGI=87909|UniProtKB=P62737	Actin, aortic smooth muscle	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000014562|UniProtKB=F7GT10	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF60	PROTOCADHERIN ALPHA-2
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001749|UniProtKB=H2Q0Q4	Uncharacterized protein	ISS	8386525	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00628	JNK1-3	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	ISS	8557110	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00021	FGF signaling pathway	P00628	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00034	Integrin signalling pathway	P00942	Fyn	XENTR|Xenbase=XB-GENE-6053489|UniProtKB=F6S8L5	Tyrosine-protein kinase	ISS	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00048	PI3 kinase pathway	P01199	Galpha	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00036	Interleukin signaling pathway	P00990	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00271	Bax	XENTR|Xenbase=XB-GENE-486067|UniProtKB=Q6P4Y4	BCL2-associated X protein	ISS	8358790	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	IC	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MOUSE|MGI=MGI=87906|UniProtKB=P63260	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	HUMAN|HGNC=4587|UniProtKB=Q14957	Glutamate receptor ionotropic, NMDA 2C	ISS	11554549	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00046	Oxidative stress response	P01130	CHOP	HUMAN|HGNC=2726|UniProtKB=P35638	DNA damage-inducible transcript 3 protein	TAS	10207617	PubMed	PTHR16833:SF0	DNA DAMAGE-INDUCIBLE TRANSCRIPT 3 PROTEIN
P00008	Axon guidance mediated by Slit/Robo	P00344	Netrin	HUMAN|HGNC=13658|UniProtKB=Q9HB63	Netrin-4	ISS	2538453	PubMed	PTHR10574:SF282	NETRIN-4
P00052	TGF-beta signaling pathway	P01284	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00047	PDGF signaling pathway	P01142	p90RSK	MACMU|Ensembl=ENSMMUG00000002134|UniProtKB=F6UNV6	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	ARATH|TAIR=AT5G07880|UniProtKB=Q9SD96	SNAP25 homologous protein SNAP29	IC			PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01396	TFIIFbeta	YEAST|SGD=S000003237|UniProtKB=P41896	Transcription initiation factor IIF subunit beta	ISS			PTHR10445:SF0	GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2
P05915	Opioid proenkephalin pathway	P05994	G-protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MOUSE|MGI=MGI=1933206|UniProtKB=A2AIR5	Protein Grin3a	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	STRPU|EnsemblGenome=SPU_017814|UniProtKB=W4YPT6	Uncharacterized protein	ISS			PTHR23050:SF263	SUBFAMILY NOT NAMED
P02723	Adenine and hypoxanthine salvage pathway	P02810	Adenine phosphoribosyl transferase	MYCTU|EnsemblGenome=Rv2584c|UniProtKB=P9WQ07	Adenine phosphoribosyltransferase	ISS			PTHR11776:SF0	ADENINE PHOSPHORIBOSYLTRANSFERASE-RELATED
P00006	Apoptosis signaling pathway	P00317	Fos	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	TAS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00046	Oxidative stress response	P01132	c-jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=88397|UniProtKB=Q9ERZ4	Muscarinic acetylcholine receptor M2	IDA	10069496	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DANRE|ZFIN=ZDB-GENE-030131-6503|UniProtKB=Q7ZUC5	Protein kinase C delta type	ISS	11880265	PubMed	PTHR24356:SF297	PROTEIN KINASE C DELTA TYPE
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	CANLF|Ensembl=ENSCAFG00000005766|UniProtKB=F1PNW4	Uncharacterized protein	ISS	1589771	PubMed	PTHR10024:SF239	SYNAPTOTAGMIN-1
P06213	DPP signaling pathway	P06284	NEJ	DROME|FlyBase=FBgn0261617|UniProtKB=M9MS40	Nejire, isoform C	IGI	10075933	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	XENTR|Xenbase=XB-GENE-493937|UniProtKB=Q5M8T9	Actin, alpha 2, smooth muscle, aorta	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00021	FGF signaling pathway	P00644	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00586	Gq	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00274	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	HUMAN|HGNC=4587|UniProtKB=Q14957	Glutamate receptor ionotropic, NMDA 2C	IC	14698601	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00005	Angiogenesis	P00223	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01238	14-3-3	ORYSJ|EnsemblGenome=OS04G0462500|UniProtKB=Q7XTE8	14-3-3-like protein GF14-B	IDA	10407019	PubMed	PTHR18860:SF36	SUBFAMILY NOT NAMED
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	DROME|FlyBase=FBgn0032001|UniProtKB=Q9VLR3	CG8360, isoform A	ISS			PTHR11644:SF2	CYTIDINE DEAMINASE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00059	p53 pathway	P01485	p53	HUMAN|HGNC=11998|UniProtKB=P04637	Cellular tumor antigen p53	TAS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	ORNAN|Ensembl=ENSOANG00000004342|UniProtKB=F6S3B9	Uncharacterized protein	ISS	12562507	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04395	Vasopressin synthesis	P04589	Signal Peptidase	PANTR|Ensembl=ENSPTRG00000016615|UniProtKB=H2QQG6	Uncharacterized protein	ISS	1546959	PubMed	PTHR12804:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 3
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00018	EGF receptor signaling pathway	P00564	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P06587	Nicotine pharmacodynamics pathway	P06595	CHRNA3	MACMU|Ensembl=ENSMMUG00000023736|UniProtKB=F7G778	Uncharacterized protein	ISS	18005395	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P00019	Endothelin signaling pathway	P00587	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	SCHPO|PomBase=SPBC16D10.10|UniProtKB=O94642	tRNA-specific adenosine deaminase subunit tad2	ISS			PTHR11079:SF92	TRNA-SPECIFIC ADENOSINE DEAMINASE 2
P06664	Gonadotropin-releasing hormone receptor pathway	P06753	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	RCA	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ORNAN|Ensembl=ENSOANG00000007581|UniProtKB=F6QWB7	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	YEAST|SGD=S000001948|UniProtKB=P32496	26S proteasome regulatory subunit RPN12	ISS			PTHR12387:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=2136018|UniProtKB=Q9QYS1	Protein Wnt-16	IDA	11266476	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P04393	Ras Pathway	P04559	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00010	B cell activation	P00379	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00005	Angiogenesis	P00251	cPLA2	MONDO|Ensembl=ENSMODG00000011791|UniProtKB=F7CBU9	Phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00020	FAS signaling pathway	P00620	CytochromeC	NEUCR|EnsemblGenome=EFNCRG00000009557|UniProtKB=P07142	Cytochrome c1, heme protein, mitochondrial	IGI	9027315	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00006	Apoptosis signaling pathway	P00269	MAPK	ORYSJ|EnsemblGenome=OS06G0154500|UniProtKB=Q84UI5	Mitogen-activated protein kinase 1	ISS	11707292	PubMed	PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P05918	p38 MAPK pathway	P06031	p38alpha	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	RCA	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	SCHPO|PomBase=SPBC215.08c|UniProtKB=O94313	Carbamoyl-phosphate synthase arginine-specific large chain	ISS			PTHR11405:SF48	CARBAMOYL-PHOSPHATE SYNTHASE ARGININE-SPECIFIC LARGE CHAIN
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	MOUSE|MGI=MGI=1278315|UniProtKB=Q91VN0	Low-density lipoprotein receptor-related protein 5	ISS	11907044	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P02747	Histidine biosynthesis	P02986	Phosphoribosyl ATP pyrophosphatase	ECOLI|EcoGene=EG10451|UniProtKB=P06989	Histidine biosynthesis bifunctional protein HisIE	ISS			PTHR42945:SF1	HISTIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN HISIE, CHLOROPLASTIC
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-7595|UniProtKB=Q6PBR4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P02738	De novo purine biosynthesis	P02899	GMP synthase	MYCTU|EnsemblGenome=Rv3396c|UniProtKB=P9WMS7	GMP synthase [glutamine-hydrolyzing]	ISS			PTHR11922:SF2	GMP SYNTHASE  GLUTAMINE-HYDROLYZING
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	PANTR|Ensembl=ENSPTRG00000018449|UniProtKB=H2QTG5	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00035	Interferon-gamma signaling pathway	P00956	SOCS	BOVIN|Ensembl=ENSBTAG00000021988|UniProtKB=Q0VC91	Suppressor of cytokine signaling 4	ISS	10500304	PubMed	PTHR44282:SF2	SUPPRESSOR OF CYTOKINE SIGNALING 4
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00005	Angiogenesis	P00237	FRP	MOUSE|MGI=MGI=1196625|UniProtKB=O70421	Frizzled-1	ISS	12549854	PubMed	PTHR11309:SF81	FRIZZLED-1
P00009	Axon guidance mediated by netrin	P00357	Netrin	HUMAN|HGNC=8029|UniProtKB=O95631	Netrin-1	ISS	9427245	PubMed	PTHR10574:SF365	NETRIN-1
P02724	Alanine biosynthesis	P02815	Branched chain amino acid aminotransferase	HALSA|EnsemblGenome=VNG_2122G|UniProtKB=Q9HNF8	Branched-chain amino acid aminotransferase	ISS			PTHR42743:SF3	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE-LIKE PROTEIN 1-RELATED
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00060	Ubiquitin proteasome pathway	P01491	E2	MACMU|Ensembl=ENSMMUG00000011325|UniProtKB=F6UEX6	Ubiquitin-conjugating enzyme E2 K	ISS			PTHR44020:SF2	UBIQUITIN-CONJUGATING ENZYME E2 K
P00036	Interleukin signaling pathway	P00965	ERK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	HUMAN|HGNC=6692|UniProtKB=Q07954	Prolow-density lipoprotein receptor-related protein 1	IDA	11907044	PubMed	PTHR44025:SF2	PROLOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	XENTR|Xenbase=XB-GENE-5753573|UniProtKB=F6WKZ2	Uncharacterized protein (Fragment)	ISS	1333052	PubMed	PTHR24241:SF123	SUBFAMILY NOT NAMED
P00059	p53 pathway	P04609	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12701063	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00036	Interleukin signaling pathway	P00975	RasGAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	TAS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00627	ERK1-2	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00627	ERK1-2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00920	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00053	T cell activation	P01311	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00049	Parkinson disease	P01219	SAPK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00010	B cell activation	P00367	NFAT	PANTR|Ensembl=ENSPTRG00000006218|UniProtKB=H2Q834	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00053	T cell activation	P01315	Calcineurin	RAT|RGD=3382|UniProtKB=P63329	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	IGI	12015605	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	TAS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	ORNAN|Ensembl=ENSOANG00000002061|UniProtKB=F7ANC6	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	PANTR|Ensembl=ENSPTRG00000028511|UniProtKB=H2R570	Uncharacterized protein	ISS	12549854	PubMed	PTHR11309:SF81	FRIZZLED-1
P00021	FGF signaling pathway	P00627	ERK1-2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	PANTR|Ensembl=ENSPTRG00000000843|UniProtKB=H2QZN8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05913	Enkephalin release	P05972	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS			PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	BOVIN|Ensembl=ENSBTAG00000014600|UniProtKB=E1BQ12	Uncharacterized protein	ISS	8163524	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10875333	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000010521|UniProtKB=F7DQK7	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DICPU|Gene=DICPUDRAFT_48914|UniProtKB=F0ZK40	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF154	ACTIN-17-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	MOUSE|MGI=MGI=99673|UniProtKB=P84309	Adenylate cyclase type 5	ISS	2491850	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00048	PI3 kinase pathway	P01188	Gbetagamma	CANLF|Ensembl=ENSCAFG00000002044|UniProtKB=P63210	Guanine nucleotide-binding protein G(T) subunit gamma-T1	ISS	3100519	PubMed	PTHR13809:SF26	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT GAMMA-T1
P00056	VEGF signaling pathway	P01402	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	RCA			PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	20216076	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00047	PDGF signaling pathway	P01172	c-Myc	DANRE|ZFIN=ZDB-GENE-990415-162|UniProtKB=P52160	Transcriptional regulator Myc-A	ISS	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00037	Ionotropic glutamate receptor pathway	P01020	NSF	CHICK|Ensembl=ENSGALG00000001055|UniProtKB=E1BQU4	Uncharacterized protein	ISS	601633	OMIM	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00005	Angiogenesis	P00227	PLA2	CANLF|Ensembl=ENSCAFG00000013778|UniProtKB=F6UQ33	Phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00059	p53 pathway	P04618	PML	MOUSE|MGI=MGI=104662|UniProtKB=Q60953	Protein PML	ISS			PTHR45211:SF1	PROTEIN PML
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	TAS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	HUMAN|HGNC=7579|UniProtKB=P35579	Myosin-9	ISS	89264452	PubMed	PTHR13140:SF317	MYOSIN-9
P00034	Integrin signalling pathway	P00925	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	RAT|RGD=620003|UniProtKB=O08773	Regulator of G-protein signaling 14	IDA	10779778	PubMed	PTHR10845:SF179	REGULATOR OF G-PROTEIN SIGNALING 14
P00053	T cell activation	P01319	PAK	CANLF|Ensembl=ENSCAFG00000013067|UniProtKB=E2RJA0	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00036	Interleukin signaling pathway	P00968	Ikk	HUMAN|HGNC=1974|UniProtKB=O15111	Inhibitor of nuclear factor kappa-B kinase subunit alpha	IC	12813046	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P04393	Ras Pathway	P04552	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	XENTR|Xenbase=XB-GENE-960304|UniProtKB=F7A0Y4	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF147	MATRIX METALLOPROTEINASE-21
P00029	Huntington disease	G01530	HTT	MACMU|Ensembl=ENSMMUG00000008392|UniProtKB=F6VQZ3	Uncharacterized protein	ISS	9462744	PubMed	PTHR10170:SF10	HUNTINGTIN
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05918	p38 MAPK pathway	P06026	MEKK4	RAT|RGD=1311192|UniProtKB=A0A0G2K3R1	Protein Map3k4	ISS	11730323	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00029	Huntington disease	P00788	Calpain	MACMU|Ensembl=ENSMMUG00000013475|UniProtKB=F6ZLR4	Uncharacterized protein	ISS	11675509	PubMed	PTHR10183:SF284	CALPAIN-1 CATALYTIC SUBUNIT
P04393	Ras Pathway	P04563	Ets	MOUSE|MGI=MGI=95455|UniProtKB=P27577	Protein C-ets-1	ISS	3060801	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PHYIT|EnsemblGenome=PITG_15078|UniProtKB=D0NRL5	Actin-like protein	IDA			PTHR11937:SF155	ACTIN-5C-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00025	Hedgehog signaling pathway	P00692	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01093	AChE	MACMU|Ensembl=ENSMMUG00000021257|UniProtKB=F7HPD6	Carboxylic ester hydrolase	ISS	87080761	PubMed	PTHR43918:SF3	ACETYLCHOLINESTERASE
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	IDA	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05726	2-arachidonoylglycerol biosynthesis	P05736	DGL	BOVIN|Ensembl=ENSBTAG00000012855|UniProtKB=P11151	Lipoprotein lipase	RCA			PTHR11610:SF3	LIPOPROTEIN LIPASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CAEEL|WormBase=WBGene00000065|UniProtKB=P0DM42	Actin-3	IC	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	RCA	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P02783	Tryptophan biosynthesis	P03208	Tryptophan synthase B	DEIRA|EnsemblGenome=DR_0941|UniProtKB=Q9RVT1	Tryptophan synthase beta chain	ISS			PTHR42882:SF1	TRYPTOPHAN SYNTHASE
P00030	Hypoxia response via HIF activation	P00819	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00009	Axon guidance mediated by netrin	P00363	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00586	Gq	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04398	p53 pathway feedback loops 2	P04657	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	IDA	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00049	Parkinson disease	P01211	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00371	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CHICK|Ensembl=ENSGALG00000001183|UniProtKB=Q789A6	Nonmuscle myosin heavy chain	IC	89264452	PubMed	PTHR13140:SF328	MYOSIN-10
P00021	FGF signaling pathway	P00632	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CHICK|Ensembl=ENSGALG00000027684|UniProtKB=P09653	Tubulin beta-5 chain	ISS	9454836	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	SCLS1|EnsemblGenome=SS1G_03482|UniProtKB=A7EDU2	Guanine nucleotide-binding protein beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P05913	Enkephalin release	P05972	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00786	ARF	MACMU|Ensembl=ENSMMUG00000011516|UniProtKB=F7C5U3	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF119	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 4C
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IGI	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	ARATH|TAIR=AT5G26710|UniProtKB=O82462	Glutamate--tRNA ligase, cytoplasmic	ISS			PTHR43097:SF8	GLUTAMATE--TRNA LIGASE, CYTOPLASMIC
P04397	p53 pathway by glucose deprivation	P04641	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01448	CBP	ARATH|TAIR=AT1G55970|UniProtKB=Q9LG11	Histone acetyltransferase HAC4	IDA	10823891	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00892	Grb2	CAEBR|Gene=CBG16856|UniProtKB=A8XPY6	Protein CBR-SEM-5	ISS	11457149	PubMed	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	MACMU|Ensembl=ENSMMUG00000017985|UniProtKB=F7DN31	Uncharacterized protein	ISS	1768802	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	HUMAN|HGNC=7567|UniProtKB=P12882	Myosin-1	ISS	89264452	PubMed	PTHR13140:SF484	MYOSIN-1
P00048	PI3 kinase pathway	P01179	PKB	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	LEIMA|EnsemblGenome=LmjF.33.0792|UniProtKB=Q4Q4C4	Beta tubulin	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00012	Cadherin signaling pathway	P00475	Frizzled	MONDO|Ensembl=ENSMODG00000006737|UniProtKB=F7CDC6	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF90	FRIZZLED-8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	FUSNN|EnsemblGenome=FN0240|UniProtKB=Q8RGP6	Thymidylate synthase	ISS			PTHR11548:SF1	SUBFAMILY NOT NAMED
P05730	Endogenous cannabinoid signaling	P05746	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P02738	De novo purine biosynthesis	P02898	Phosphoribosylformylglycinamide  synthase	AQUAE|EnsemblGenome=aq_1836|UniProtKB=O67691	Phosphoribosylformylglycinamidine synthase subunit PurL	ISS			PTHR43555:SF1	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04398	p53 pathway feedback loops 2	P04658	PTEN	ARATH|TAIR=AT5G39400|UniProtKB=Q9FLZ5	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN1	ISS			PTHR12305:SF80	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND PROTEIN-TYROSINE-PHOSPHATASE PTEN1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00059	p53 pathway	P04633	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	RAT|RGD=1597456|UniProtKB=D4A898	Protein Tbpl1	ISS	600075	OMIM	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g234494|UniProtKB=A7RU31	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00019	Endothelin signaling pathway	P00591	PLCbeta	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00046	Oxidative stress response	P01131	MKP5	MONDO|Ensembl=ENSMODG00000010566|UniProtKB=F6YR54	Uncharacterized protein	ISS			PTHR10159:SF402	DUAL SPECIFICITY PROTEIN PHOSPHATASE 19
P00047	PDGF signaling pathway	P01143	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05913	Enkephalin release	P05978	AC	BOVIN|Ensembl=ENSBTAG00000019210|UniProtKB=F1MJV4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	MOUSE|MGI=MGI=106217|UniProtKB=Q61290	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	14624853	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P05915	Opioid proenkephalin pathway	P05990	K+ channel	DANRE|ZFIN=ZDB-GENE-040724-171|UniProtKB=Q5TZ59	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P06959	CCKR signaling map	P07121	MAP2K2	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	RCA	15153424	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00057	Wnt signaling pathway	P01468	APC	BOVIN|Ensembl=ENSBTAG00000018852|UniProtKB=F1MV51	Uncharacterized protein	ISS	8259518	PubMed	PTHR12607:SF11	ADENOMATOUS POLYPOSIS COLI PROTEIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	HUMAN|HGNC=1956|UniProtKB=Q15822	Neuronal acetylcholine receptor subunit alpha-2	IC	85270494	PubMed	PTHR18945:SF757	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-2
P00057	Wnt signaling pathway	P01443	Phospholipase C	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=109356|UniProtKB=O09044	Synaptosomal-associated protein 23	IC	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00020	FAS signaling pathway	P00615	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000010393|UniProtKB=F7D992	Uncharacterized protein	ISS	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	PANTR|Ensembl=ENSPTRG00000004217|UniProtKB=H2Q4M9	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF115	MATRIX METALLOPROTEINASE-27
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	MOUSE|MGI=MGI=1338938|UniProtKB=P36895	Bone morphogenetic protein receptor type-1A	TAS	10683140	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P05915	Opioid proenkephalin pathway	P05994	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	RCA	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	TAKRU|Ensembl=ENSTRUG00000003520|UniProtKB=H2S791	Uncharacterized protein	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	88241036	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	1504106	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00046	Oxidative stress response	P01134	cPLA2	MACMU|Ensembl=ENSMMUG00000021423|UniProtKB=F7EEZ1	Phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	MOUSE|MGI=MGI=95806|UniProtKB=P63002	Amino-terminal enhancer of split	IDA	9783586	PubMed	PTHR10814:SF4	AMINO-TERMINAL ENHANCER OF SPLIT-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	HUMAN|HGNC=174|UniProtKB=Q13705	Activin receptor type-2B	TAS	11252892	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P00021	FGF signaling pathway	P00627	ERK1-2	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	NAS	13430383	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04376	5HT4 type receptor mediated signaling pathway	P04426	K+ channel	MOUSE|MGI=MGI=3521816|UniProtKB=Q3LS21	Potassium channel subfamily K member 9	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	IC	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00108	ADAM10	ORNAN|Ensembl=ENSOANG00000009151|UniProtKB=F7EK00	Uncharacterized protein	ISS	12354787	PubMed	PTHR11905:SF4	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 10
P05912	Dopamine receptor mediated signaling pathway	P05957	K+ channel	BOVIN|Ensembl=ENSBTAG00000047488|UniProtKB=G3N1D1	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00029	Huntington disease	P00796	Kainate receptor	MONDO|Ensembl=ENSMODG00000020977|UniProtKB=F6S5B1	Uncharacterized protein (Fragment)	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CANLF|Ensembl=ENSCAFG00000015662|UniProtKB=E2RHY4	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01177	P110ACT	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04393	Ras Pathway	P04560	AP1	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	MOUSE|MGI=MGI=95794|UniProtKB=A2ARV4	Low-density lipoprotein receptor-related protein 2	ISS	11907044	PubMed	PTHR44025:SF5	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00193	SOS-1	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MOUSE|MGI=MGI=1933206|UniProtKB=A2AIR5	Protein Grin3a	ISS	14698601	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00030	Hypoxia response via HIF activation	P00821	Prolyl Hydroxylase	RAT|RGD=631376|UniProtKB=Q6AYU4	Egl nine homolog 2	ISS	12912907	PubMed	PTHR12907:SF6	EGL NINE HOMOLOG 2
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	PANTR|Ensembl=ENSPTRG00000007461|UniProtKB=H2QA34	Furin (Paired basic amino acid cleaving enzyme)	ISS	95328031	PubMed	PTHR42884:SF1	FURIN
P00045	Notch signaling pathway	P01111	LNXp80	MACMU|Ensembl=ENSMMUG00000017401|UniProtKB=F7HS14	Uncharacterized protein	ISS			PTHR19964:SF14	E3 UBIQUITIN-PROTEIN LIGASE LNX
P00036	Interleukin signaling pathway	P00965	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IC	10644715	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00012	Cadherin signaling pathway	P00470	F-actin	ORNAN|Ensembl=ENSOANG00000000460|UniProtKB=F7F4W9	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02771	Pyrimidine Metabolism	P03124	Methylmalonate Semialdehyde Dehydrogenase	PSEAE|EnsemblGenome=PA3570|UniProtKB=P28810	Methylmalonate-semialdehyde dehydrogenase [acylating]	ISS	10984043	PubMed	PTHR43866:SF8	SUBFAMILY NOT NAMED
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00020	FAS signaling pathway	P00602	DAXX	PANTR|Ensembl=ENSPTRG00000018045|UniProtKB=H2QST5	Uncharacterized protein	ISS	10698492	PubMed	PTHR12766:SF7	DEATH DOMAIN-ASSOCIATED PROTEIN 6
P00006	Apoptosis signaling pathway	P00260	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	MOUSE|MGI=MGI=94924|UniProtKB=P61168	D(2) dopamine receptor	ISS	1319557	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	HUMAN|HGNC=9999|UniProtKB=P49796	Regulator of G-protein signaling 3	IDA	8756726	PubMed	PTHR10845:SF4	REGULATOR OF G-PROTEIN SIGNALING 3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05730	Endogenous cannabinoid signaling	P05746	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00012	Cadherin signaling pathway	P00470	F-actin	MOUSE|MGI=MGI=2444552|UniProtKB=Q8BFZ3	Beta-actin-like protein 2	IC	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00010	B cell activation	P00402	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	TAS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_79607|UniProtKB=C3ZHN4	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P04373	5HT1 type receptor mediated signaling pathway	P04409	5HT transporter	RAT|RGD=3714|UniProtKB=P31652	Sodium-dependent serotonin transporter	IEA	7681602	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P05915	Opioid proenkephalin pathway	P05994	G-protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	SCLS1|EnsemblGenome=SS1G_03482|UniProtKB=A7EDU2	Guanine nucleotide-binding protein beta subunit	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=1100883|UniProtKB=O35161	Cadherin EGF LAG seven-pass G-type receptor 1	IDA	8120095	PubMed	PTHR24026:SF36	CADHERIN EGF LAG SEVEN-PASS G-TYPE RECEPTOR 1
P00023	General transcription regulation	P00668	TFIIB	DANRE|ZFIN=ZDB-GENE-040801-43|UniProtKB=A8KBY2	Transcription factor IIIB 50 kDa subunit	ISS	180660	OMIM	PTHR11618:SF5	TRANSCRIPTION FACTOR IIIB 50 KDA SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000009085|UniProtKB=H2RDQ2	Uncharacterized protein	ISS	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00019	Endothelin signaling pathway	P00586	Gq	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01472	Histone deacetylase	LEIMA|EnsemblGenome=LmjF.21.0680|UniProtKB=Q4QCE7	Histone deacetylase	IDA	10485845	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P00047	PDGF signaling pathway	P01167	Ets	RAT|RGD=1594842|UniProtKB=B2RYE0	Protein Spdef	ISS	15298723	PubMed	PTHR11849:SF182	SAM POINTED DOMAIN-CONTAINING ETS TRANSCRIPTION FACTOR
P00047	PDGF signaling pathway	P01160	IP3 receptor	CAEBR|Gene=CBG_05938|UniProtKB=H8WGV2	Protein CBR-ITR-1, isoform a	ISS	9065779	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P05913	Enkephalin release	P05977	G-Protein (s)	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IGI	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00056	VEGF signaling pathway	P01408	Akt/PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00205	GAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	8262392	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00049	Parkinson disease	P01207	PLD2	MACMU|Ensembl=ENSMMUG00000005666|UniProtKB=F6VWY6	Uncharacterized protein	ISS	12615079	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P00013	Cell cycle	P00483	Cyclin E	RAT|RGD=2294|UniProtKB=P39949	G1/S-specific cyclin-E1	ISS	15705141	gi	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	IC	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BOVIN|Ensembl=ENSBTAG00000008097|UniProtKB=A4D7S0	Protein Wnt-2	ISS	11266476	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000015241|UniProtKB=Q5IS72	D(3) dopamine receptor	ISS	2039532	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00547	PP2A	PANTR|Ensembl=ENSPTRG00000001958|UniProtKB=H2Q137	Uncharacterized protein	ISS	12110603	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01211	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05913	Enkephalin release	P05972	PKA	LEIMA|EnsemblGenome=LmjF.35.4010|UniProtKB=Q9GNR4	Protein kinase A catalytic subunit isoform 1	ISS	10553940	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	RAT|RGD=1307690|UniProtKB=D4A0I8	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (Predicted), isoform CRA_b	ISS	9133421	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00034	Integrin signalling pathway	P00907	ERK	MACMU|Ensembl=ENSMMUG00000012387|UniProtKB=F7EB20	Uncharacterized protein	ISS			PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00048	PI3 kinase pathway	P01179	PKB	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00477	GSK3beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00017	DNA replication	P00534	PCNA	HUMAN|HGNC=8729|UniProtKB=P12004	Proliferating cell nuclear antigen	IDA	12893285	PubMed	PTHR11352:SF0	PROLIFERATING CELL NUCLEAR ANTIGEN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01242	Casein kinase I	YEAST|SGD=S000006125|UniProtKB=P29295	Casein kinase I homolog HRR25	IDA	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	BOVIN|Ensembl=ENSBTAG00000012046|UniProtKB=Q0VBZ5	Transcription factor jun-B	ISS	10664585	PubMed	PTHR11462:SF37	TRANSCRIPTION FACTOR JUN-B
P00048	PI3 kinase pathway	P01192	p110	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00292	IkappaB	RAT|RGD=3171|UniProtKB=Q63746	NF-kappa-B inhibitor alpha	ISS	99081292	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00057	Wnt signaling pathway	P01452	NFAT	BOVIN|Ensembl=ENSBTAG00000004368|UniProtKB=F1MSU2	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	RAT|RGD=1308057|UniProtKB=F1M077	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00057	Wnt signaling pathway	P01428	Frizzled	RAT|RGD=61916|UniProtKB=Q08463	Frizzled-1	IDA	8717036	PubMed	PTHR11309:SF81	FRIZZLED-1
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00546	GAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	IGI	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00056	VEGF signaling pathway	P01422	eNOS	PANTR|Ensembl=ENSPTRG00000019868|UniProtKB=H2QVM2	Nitric oxide synthase	ISS	10435050	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02738	De novo purine biosynthesis	P02909	GDP reductase	BACSU|EnsemblGenome=BSU17390|UniProtKB=P50621	Ribonucleoside-diphosphate reductase subunit beta	ISS			PTHR23409:SF32	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT BETA
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04541	p90RSK	HUMAN|HGNC=10435|UniProtKB=Q9UK32	Ribosomal protein S6 kinase alpha-6	IDA	6755374	gi	PTHR24351:SF98	RIBOSOMAL PROTEIN S6 KINASE ALPHA-6
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	RAT|RGD=2089|UniProtKB=P05065	Fructose-bisphosphate aldolase A	ISS	3391172	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01439	C-terminal Binding Protein	PANTR|Ensembl=ENSPTRG00000003035|UniProtKB=H2Q2Q9	Uncharacterized protein	ISS	10375506	PubMed	PTHR10996:SF72	C-TERMINAL-BINDING PROTEIN 2
P00010	B cell activation	P00397	IKK	RAT|RGD=621375|UniProtKB=Q9QY78	Inhibitor of nuclear factor kappa-B kinase subunit beta	IGI	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	PANTR|Ensembl=ENSPTRG00000022187|UniProtKB=Q7YQL4	Serine/threonine-protein kinase PAK 3	ISS	7559398	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014262|UniProtKB=F7BYS8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00007	Axon guidance mediated by semaphorins	P00340	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	PANTR|Ensembl=ENSPTRG00000009796|UniProtKB=H2QE47	Casein kinase 1, delta	ISS	10617630	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P04393	Ras Pathway	P04541	p90RSK	CHICK|Ensembl=ENSGALG00000011473|UniProtKB=F1P1H2	Ribosomal protein S6 kinase	ISS	15526037	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	15737619	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	MACMU|Ensembl=ENSMMUG00000004527|UniProtKB=F6SCN9	C-X-C motif chemokine	ISS	9910486	gi	PTHR10179:SF43	PLATELET FACTOR 4
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1346874|UniProtKB=Q61084	Mitogen-activated protein kinase kinase kinase 3	IC			PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00561	STAT	HUMAN|HGNC=11366|UniProtKB=P42229	Signal transducer and activator of transcription 5A	IGI	95236292	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_114976|UniProtKB=C3YP58	Putative uncharacterized protein	IDA	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00034	Integrin signalling pathway	P00936	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IPI	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00011	Blood coagulation	P00429	PN2	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00019	Endothelin signaling pathway	P00590	IP3 R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00048	PI3 kinase pathway	P01192	p110	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00391	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00790	beta-Tubulin	PANTR|Ensembl=ENSPTRG00000027750|UniProtKB=H2QS82	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IDA	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	RCA	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000000365|UniProtKB=F6R9F4	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00056	VEGF signaling pathway	P01419	Ets	MONDO|Ensembl=ENSMODG00000004730|UniProtKB=F6Y1Z2	Uncharacterized protein	ISS	3060801	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	BOVIN|Ensembl=ENSBTAG00000017639|UniProtKB=F1MZW8	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P04375	5HT3 type receptor mediated signaling pathway	P04425	K+ channel	PANTR|Ensembl=ENSPTRG00000020614|UniProtKB=H2QWR7	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P02775	Salvage pyrimidine ribonucleotides	P03151	Uracil phosphoribosyl  transferase	SCHPO|PomBase=SPAC1399.04c|UniProtKB=Q9HE15	Uracil phosphoribosyltransferase 2	ISS			PTHR10285:SF90	URACIL PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00019	Endothelin signaling pathway	P00570	PKA	NEUCR|EnsemblGenome=EFNCRG00000004240|UniProtKB=Q01386	cAMP-dependent protein kinase regulatory subunit	IGI	2372396	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00916	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	TAS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00018	EGF receptor signaling pathway	P00563	Gab	MOUSE|MGI=MGI=2387324|UniProtKB=Q8BSM5	GRB2-associated-binding protein 3	ISS	20984358	gi	PTHR12156:SF2	GRB2-ASSOCIATED-BINDING PROTEIN 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00006	Apoptosis signaling pathway	P00269	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	IC	91072385	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	TAS	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04433	Beta1	HUMAN|HGNC=285|UniProtKB=P08588	Beta-1 adrenergic receptor	ISS	12063255	PubMed	PTHR24248:SF54	BETA-1 ADRENERGIC RECEPTOR
P00054	Toll receptor signaling pathway	P01375	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	ANOGA|EnsemblGenome=AGAP005911|UniProtKB=Q7Q6D4	AGAP005911-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00005	Angiogenesis	P00221	JNK1	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00050	Plasminogen activating cascade	P01252	MMP-1	MACMU|Ensembl=ENSMMUG00000002037|UniProtKB=F6WYF2	Uncharacterized protein	ISS	3009463	PubMed	PTHR10201:SF151	INTERSTITIAL COLLAGENASE
P00046	Oxidative stress response	P01135	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05916	Opioid prodynorphin pathway	P06002	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05913	Enkephalin release	P05972	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176910	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00053	T cell activation	P01294	NFAT	BOVIN|Ensembl=ENSBTAG00000004368|UniProtKB=F1MSU2	Uncharacterized protein	ISS	12787506	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00048	PI3 kinase pathway	P01194	S6K	RAT|RGD=1305144|UniProtKB=D4AE24	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	HUMAN|HGNC=11544|UniProtKB=Q15544	Transcription initiation factor TFIID subunit 11	ISS			PTHR13218:SF16	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11
P00054	Toll receptor signaling pathway	P01358	ERK1	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00379	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=1953|UniProtKB=P08173	Muscarinic acetylcholine receptor M4	IDA	8100450	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	RAT|RGD=61801|UniProtKB=P30994	5-hydroxytryptamine receptor 2B	ISS	12441358	PubMed	PTHR24247:SF31	5-HYDROXYTRYPTAMINE RECEPTOR 2B
P00005	Angiogenesis	P00252	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	8235613	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00627	ERK1-2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04398	p53 pathway feedback loops 2	P04651	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00005	Angiogenesis	P00203	Erk	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CAEEL|WormBase=WBGene00006374|UniProtKB=P91409	Putative syntaxin-4	IC			PTHR19957:SF142	SYNTAXIN-4-RELATED
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	STRCO|Gene=CAB91115|UniProtKB=Q9KYT6	Putative aldehyde dehydrogenase	IC	14724059	PubMed	PTHR42991:SF1	ALDEHYDE DEHYDROGENASE
P00034	Integrin signalling pathway	P00931	Integrin beta	MONDO|Ensembl=ENSMODG00000007536|UniProtKB=K7E435	Integrin beta	ISS	10706722	PubMed	PTHR10082:SF28	INTEGRIN BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000006307|UniProtKB=H2SSM1	Uncharacterized protein	IC			PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=3346|UniProtKB=P10688	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	7822322	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00059	p53 pathway	G04694	p110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00048	PI3 kinase pathway	P01185	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00005	Angiogenesis	P00211	GSK3beta	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	XENTR|Xenbase=XB-GENE-493937|UniProtKB=Q5M8T9	Actin, alpha 2, smooth muscle, aorta	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CAEEL|WormBase=WBGene00003774|UniProtKB=G5EGQ9	NMDA class glutamate Receptor	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00897	SHIP2	MOUSE|MGI=MGI=1333787|UniProtKB=Q6P549	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	ISS	12145149	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IDA	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CHICK|Ensembl=ENSGALG00000017178|UniProtKB=F1N982	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00804	Synaptojanin	CAEBR|Gene=CBG01799|UniProtKB=A8WQT0	Protein CBR-UNC-26	ISS			PTHR11200:SF256	GH06496P
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	XENTR|Ensembl=ENSXETG00000023047|UniProtKB=F6S675	Inosine-5'-monophosphate dehydrogenase 1	ISS			PTHR11911:SF74	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00018	EGF receptor signaling pathway	P00548	RKIP	DROME|FlyBase=FBgn0265272|UniProtKB=Q29QL9	IP07080p	ISS			PTHR11362:SF28	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P00054	Toll receptor signaling pathway	P01338	IkappaB	RAT|RGD=3171|UniProtKB=Q63746	NF-kappa-B inhibitor alpha	ISS	10869418	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00048	PI3 kinase pathway	P01188	Gbetagamma	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00015	Circadian clock system	G01497	cry	DANRE|ZFIN=ZDB-GENE-010426-5|UniProtKB=F1QU08	Uncharacterized protein	ISS			PTHR11455:SF10	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000018989|UniProtKB=A5D7D8	GRM3 protein	ISS	20012997	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P04398	p53 pathway feedback loops 2	P04665	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P06210	Activin beta signaling pathway	P06230	LACK	DROME|FlyBase=FBgn0029006|UniProtKB=Q9V853	E3 ubiquitin-protein ligase Smurf1	IEA	http://flybase.org/reports/FBgn0029006.html	Website	PTHR11254:SF395	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	CHICK|Ensembl=ENSGALG00000011699|UniProtKB=F1NEC3	Uncharacterized protein	IGI	2491850	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	RCA	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00634	MEKK1-5	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS	12878610	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P06959	CCKR signaling map	P07097	SAP1	HUMAN|HGNC=3326|UniProtKB=P28324	ETS domain-containing protein Elk-4	RCA	9950815	PubMed	PTHR11849:SF21	ETS DOMAIN-CONTAINING PROTEIN ELK-4
P00025	Hedgehog signaling pathway	P00682	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	IDA	15313841	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000014571|UniProtKB=F7GRQ8	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF119	PROTOCADHERIN ALPHA-C2
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=98329|UniProtKB=P30935	Somatostatin receptor type 3	IDA	12441358	PubMed	PTHR24229:SF42	SOMATOSTATIN RECEPTOR TYPE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00633	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IGI	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MOUSE|MGI=MGI=87909|UniProtKB=P62737	Actin, aortic smooth muscle	IC	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	TAS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IDA	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05916	Opioid prodynorphin pathway	P06002	G-protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	ISS	10704417	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P02785	Valine biosynthesis	P03215	Branched chain amino acid aminotransferase	AQUAE|EnsemblGenome=aq_1893|UniProtKB=O67733	Probable branched-chain-amino-acid aminotransferase	ISS			PTHR42743:SF4	SUBFAMILY NOT NAMED
P00049	Parkinson disease	P01242	Casein kinase I	XENTR|Xenbase=XB-GENE-478121|UniProtKB=F6VPH2	Uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00227	PLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00017	DNA replication	P00527	Histones	PHYIT|EnsemblGenome=PITG_03551|UniProtKB=D0MXW5	Histone H3	ISS	12413958	PubMed	PTHR11426:SF169	HISTONE H3
P00057	Wnt signaling pathway	P01465	Ggamma	DROME|FlyBase=FBgn0267252|UniProtKB=Q9NFZ3	Guanine nucleotide-binding protein subunit gamma-e	IDA	10391901	PubMed	PTHR15936:SF2	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-13
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DANRE|ZFIN=ZDB-GENE-040426-1489|UniProtKB=Q6PHV0	Syntaxin 3A	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00019	Endothelin signaling pathway	P00578	eNOS	MACMU|Ensembl=ENSMMUG00000020437|UniProtKB=F6WEB2	Nitric oxide synthase	ISS	10435050	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	MACMU|Ensembl=ENSMMUG00000023796|UniProtKB=F7HRC7	Fructose-bisphosphate aldolase	ISS	8086469	PubMed	PTHR11627:SF2	FRUCTOSE-BISPHOSPHATE ALDOLASE B
P00060	Ubiquitin proteasome pathway	P01491	E2	PRIPA|Gene=PPA08876|UniProtKB=H3EGL4	Let-70	ISS			PTHR24068:SF74	FI16911P1-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	DAPPU|EnsemblGenome=DAPPUDRAFT_442795|UniProtKB=E9H5Z2	Calmodulin	ISS	10487978	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00021	FGF signaling pathway	P00629	PP2A	BOVIN|Ensembl=ENSBTAG00000009245|UniProtKB=Q0P594	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	TAS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00049	Parkinson disease	P01211	ERK	ORYSJ|EnsemblGenome=OS02G0148100|UniProtKB=Q6Z437	Mitogen-activated protein kinase 3	IDA	10851062	PubMed	PTHR24055:SF216	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00796	Kainate receptor	MOUSE|MGI=MGI=95818|UniProtKB=Q61626	Glutamate receptor ionotropic, kainate 5	IDA	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	RAT|RGD=619712|UniProtKB=Q63651	Rhodopsin kinase	IDA	8288567	PubMed	PTHR24355:SF11	RHODOPSIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P06959	CCKR signaling map	P07035	FOS	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	RCA	15136564	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00010	B cell activation	P00375	Calmodulin	TAKRU|Ensembl=ENSTRUG00000008685|UniProtKB=H2TXN3	Uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF326	CALMODULIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00048	PI3 kinase pathway	P01192	p110	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00029	Huntington disease	P00788	Calpain	PANTR|Ensembl=ENSPTRG00000034200|UniProtKB=H2RBT6	Uncharacterized protein	ISS	11675509	PubMed	PTHR10183:SF329	CALPAIN-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	HUMAN|HGNC=4588|UniProtKB=O15399	Glutamate receptor ionotropic, NMDA 2D	IC	14698601	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	MACMU|Ensembl=ENSMMUG00000023736|UniProtKB=F7G778	Uncharacterized protein	ISS	12098588	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P00049	Parkinson disease	P01227	20S proteasome	PANTR|Ensembl=ENSPTRG00000009933|UniProtKB=H2QED5	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF47	PROTEASOME SUBUNIT ALPHA TYPE-7-LIKE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	ORNAN|Ensembl=ENSOANG00000011166|UniProtKB=F7D5G3	Phosphoinositide phospholipase C	ISS			PTHR10336:SF84	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2
P00052	TGF-beta signaling pathway	P01284	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00030	Hypoxia response via HIF activation	P00819	AKT	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	IC	12719720	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00029	Huntington disease	P00807	Actin	PHYPA|Gene=PHYPADRAFT_109052|UniProtKB=A9TZ58	Actin 5	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05913	Enkephalin release	P05974	G-Protein (i)	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	IC	10704417	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00029	Huntington disease	P00778	NMDA receptor	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04380	Cortocotropin releasing factor receptor signaling pathway	P04454	CRF	RAT|RGD=620505|UniProtKB=P01143	Corticoliberin	ISS	122560	OMIM	PTHR15035:SF9	CORTICOLIBERIN
P00019	Endothelin signaling pathway	P00590	IP3 R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00036	Interleukin signaling pathway	P00995	c-Myc	MACMU|Ensembl=ENSMMUG00000014601|UniProtKB=B8XIA5	Myc proto-oncogene protein	ISS	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00029	Huntington disease	P00780	Microtubule	DANRE|ZFIN=ZDB-GENE-031110-4|UniProtKB=Q6NW90	Tubulin, beta 5	ISS	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00029	Huntington disease	P00788	Calpain	BOVIN|Ensembl=ENSBTAG00000000828|UniProtKB=E1BJ18	Uncharacterized protein	ISS	11675509	PubMed	PTHR10183:SF381	CALPAIN-6
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Ensembl=ENSPTRG00000000543|UniProtKB=H2PYN8	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P05918	p38 MAPK pathway	P06031	p38alpha	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P06959	CCKR signaling map	P07059	BCL2	HUMAN|HGNC=990|UniProtKB=P10415	Apoptosis regulator Bcl-2	RCA	15474972	PubMed	PTHR11256:SF11	APOPTOSIS REGULATOR BCL-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MACMU|Ensembl=ENSMMUG00000001458|UniProtKB=F7BKH1	Uncharacterized protein	ISS	9618202	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Ensembl=ENSBTAG00000013202|UniProtKB=Q1RML2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1	ISS	12860966	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	12885769	PubMed	PTHR10202:SF13	PRESENILIN-2
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IDA	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00114	actin	HUMAN|HGNC=130|UniProtKB=P62736	Actin, aortic smooth muscle	IDA	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P05918	p38 MAPK pathway	P06020	p38delta	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00012	Cadherin signaling pathway	P00470	F-actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g188243|UniProtKB=A7SCN8	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00034	Integrin signalling pathway	P00942	Fyn	CHICK|Gene=FYN|UniProtKB=Q05876	Tyrosine-protein kinase Fyn	IPI	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IDA	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02751	Lysine biosynthesis	P03007	Diaminopimelate decarboxylase	ARATH|TAIR=AT5G11880|UniProtKB=Q94A94	Diaminopimelate decarboxylase 2, chloroplastic	ISS			PTHR43727:SF2	DIAMINOPIMELATE DECARBOXYLASE 1, CHLOROPLASTIC-RELATED
P00049	Parkinson disease	P01222	Ubc6	ORNAN|Ensembl=ENSOANG00000006753|UniProtKB=F7C4Y9	Uncharacterized protein	ISS	12859888	PubMed	PTHR43972:SF1	UBIQUITIN-CONJUGATING ENZYME E2 J2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CHICK|Ensembl=ENSGALG00000011086|UniProtKB=P68139	Actin, alpha skeletal muscle	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00048	PI3 kinase pathway	P01192	p110	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00035	Interferon-gamma signaling pathway	P00953	Jak1	PANTR|Ensembl=ENSPTRG00000000825|UniProtKB=H2PZ66	Tyrosine-protein kinase	ISS	11929133	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00048	PI3 kinase pathway	P01189	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	RAT|RGD=67385|UniProtKB=Q8VGC3	Voltage-dependent L-type calcium channel subunit beta-2	IC	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	RAT|RGD=1305887|UniProtKB=Q4QQV0	Protein Tubb6	ISS	9454836	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P05730	Endogenous cannabinoid signaling	P05743	CB1	MACMU|Gene=CNR1|UniProtKB=Q71SP5	Cannabinoid receptor 1	ISS	114610	OMIM	PTHR22750:SF47	CANNABINOID RECEPTOR 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	MONDO|Ensembl=ENSMODG00000006787|UniProtKB=F6PH60	Glutamine synthetase	ISS			PTHR20852:SF45	GLUTAMINE SYNTHETASE
P00012	Cadherin signaling pathway	P00470	F-actin	CHICK|Gene=ACTG2|UniProtKB=P63270	Actin, gamma-enteric smooth muscle	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00057	Wnt signaling pathway	P01465	Ggamma	PANTR|Ensembl=ENSPTRG00000039101|UniProtKB=H2RFN4	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR15936:SF2	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-13
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P02783	Tryptophan biosynthesis	P03209	Anthranilate phosphoribosyl transferase	ECOLI|EcoGene=EG10682|UniProtKB=P00903	Aminodeoxychorismate synthase component 2	ISS			PTHR43418:SF4	MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IDA	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00775	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12912997	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00050	Plasminogen activating cascade	P01246	Plasmin	HUMAN|HGNC=6667|UniProtKB=P08519	Apolipoprotein(a)	ISS	88039109	PubMed	PTHR24261:SF2	APOLIPOPROTEIN A -RELATED
P00018	EGF receptor signaling pathway	P00551	Akt	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	IGI	12089061	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01026	KA	HUMAN|HGNC=4581|UniProtKB=Q13003	Glutamate receptor ionotropic, kainate 3	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IPI	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00010	B cell activation	P00373	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05731	GABA-B receptor II signaling	P05760	AC	RAT|RGD=2034|UniProtKB=P26770	Adenylate cyclase type 4	RCA	2491850	PubMed	PTHR11920:SF286	ADENYLATE CYCLASE TYPE 4
P00053	T cell activation	P01307	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00047	PDGF signaling pathway	P01160	IP3 receptor	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00021	FGF signaling pathway	P00639	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	8946911	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	TAKRU|Ensembl=ENSTRUG00000016101|UniProtKB=H2UW32	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IC	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	MOUSE|MGI=MGI=88296|UniProtKB=O55017	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	14507926	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00017	DNA replication	P00527	Histones	STRPU|EnsemblGenome=SPU_008980|UniProtKB=W4XZV8	Histone H3	ISS	12413958	PubMed	PTHR11426:SF20	HISTONE H3-LIKE CENTROMERIC PROTEIN A
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00049	Parkinson disease	P01236	Casein kinase II	ARATH|TAIR=AT3G60250|UniProtKB=O81275	Casein kinase II subunit beta-3	IDA	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	IC	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	HUMAN|HGNC=17780|UniProtKB=Q562R1	Beta-actin-like protein 2	IC	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P05918	p38 MAPK pathway	P06015	p38gamma	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04393	Ras Pathway	P04544	Grb2	XENTR|Xenbase=XB-GENE-6070000|UniProtKB=Q66II3	Growth factor receptor-bound protein 2	ISS	11384839	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CIOIN|Ensembl=ENSCING00000007153|UniProtKB=L7N0T1	Uncharacterized protein	ISS			PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	NAS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00008	Axon guidance mediated by Slit/Robo	P00344	Netrin	HUMAN|HGNC=14288|UniProtKB=Q96CW9	Netrin-G2	ISS			PTHR10574:SF27	NETRIN-G2
P00057	Wnt signaling pathway	P01433	SIAH-1	ARATH|TAIR=AT3G61790|UniProtKB=Q84JL3	E3 ubiquitin-protein ligase SINAT3	IDA	11389839	PubMed	PTHR10315:SF34	E3 UBIQUITIN-PROTEIN LIGASE SINAT3-RELATED
P00057	Wnt signaling pathway	P01435	SWI/SNF	YEAST|SGD=S000001388|UniProtKB=P32597	Nuclear protein STH1/NPS1	IDA	11532957	PubMed	PTHR10799:SF836	NUCLEAR PROTEIN STH1/NPS1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DROME|FlyBase=FBgn0013343|UniProtKB=Q24547	Syntaxin-1A	ISS	97410052	PubMed	PTHR19957:SF41	SYNTAXIN-1A
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	HUMAN|HGNC=16767|UniProtKB=Q8TCU5	Glutamate receptor ionotropic, NMDA 3A	ISS	11554549	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P02742	Tetrahydrofolate biosynthesis	P02945	Dihydropteroate synthase	BACTN|EnsemblGenome=BT_3646|UniProtKB=Q8A1L5	Dihydropteroate synthase	ISS			PTHR20941:SF1	FOLIC ACID SYNTHESIS PROTEIN FOL1
P00029	Huntington disease	P00790	beta-Tubulin	PHYPA|Gene=PHYPADRAFT_223212|UniProtKB=Q6TYR5	Beta-tubulin 3	ISS	9454836	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P00010	B cell activation	P00391	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00807	Actin	DICDI|dictyBase=DDB_G0289811|UniProtKB=Q54GX7	Actin-10	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	P01444	Wnt	BOVIN|Ensembl=ENSBTAG00000015364|UniProtKB=E1BEN9	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	XENTR|Xenbase=XB-GENE-6067221|UniProtKB=F6Z0J4	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00912	Arp2/3	HUMAN|HGNC=704|UniProtKB=O15143	Actin-related protein 2/3 complex subunit 1B	IPI	12473693	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00048	PI3 kinase pathway	P01192	p110	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	HUMAN|HGNC=237|UniProtKB=O43306	Adenylate cyclase type 6	IGI	2491850	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00037	Ionotropic glutamate receptor pathway	P01023	CaMKII	HUMAN|HGNC=1462|UniProtKB=Q13557	Calcium/calmodulin-dependent protein kinase type II subunit delta	ISS	12888804	PubMed	PTHR43940:SF4	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT DELTA
P00034	Integrin signalling pathway	P00938	Cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00005	Angiogenesis	P00206	Wnt	CHICK|Ensembl=ENSGALG00000014235|UniProtKB=Q3L254	Protein Wnt-7b	ISS	11266476	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	1482697	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00059	p53 pathway	P04633	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00774	Dynein complex	DAPPU|EnsemblGenome=DAPPUDRAFT_308639|UniProtKB=E9H8L6	Putative uncharacterized protein	ISS	9454836	PubMed	PTHR11886:SF62	DYNEIN, LIGHT CHAIN, LC8-TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04398	p53 pathway feedback loops 2	P04665	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	MOUSE|MGI=MGI=106684|UniProtKB=Q8R090	Chromaffin granule amine transporter	ISS	12135927	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00059	p53 pathway	G04692	R2	RAT|RGD=1598310|UniProtKB=Q4KLN6	Ribonucleoside-diphosphate reductase subunit M2	ISS			PTHR23409:SF20	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MACMU|Gene=CCR1|UniProtKB=P56482	C-C chemokine receptor type 1	ISS			PTHR10489:SF711	C-C CHEMOKINE RECEPTOR TYPE 1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00030	Hypoxia response via HIF activation	P00819	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	MOUSE|MGI=MGI=1926879|UniProtKB=Q9EQH4	Transcription initiation factor TFIID subunit 8	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	ARATH|TAIR=AT3G11130|UniProtKB=Q0WNJ6	Clathrin heavy chain 1	IDA	9388255	PubMed	PTHR10292:SF1	CLATHRIN HEAVY CHAIN
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00059	p53 pathway	P04624	Cdc25C	PANTR|Ensembl=ENSPTRG00000017284|UniProtKB=H2R4E1	Uncharacterized protein	ISS	9520381	PubMed	PTHR10828:SF64	M-PHASE INDUCER PHOSPHATASE 3
P00036	Interleukin signaling pathway	P00990	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05916	Opioid prodynorphin pathway	P06002	G-protein	BOVIN|Ensembl=ENSBTAG00000035697|UniProtKB=Q28024	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01143	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ORYSJ|EnsemblGenome=OS02G0199900|UniProtKB=Q9FXT8	26S proteasome regulatory particle triple-A ATPase subunit4	ISS			PTHR23073:SF31	26S PROTEASE REGULATORY SUBUNIT 10B
P05918	p38 MAPK pathway	P06018	MNK1	BOVIN|Gene=MKNK1|UniProtKB=Q58D94	MAP kinase-interacting serine/threonine-protein kinase 1	ISS	97299868	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IDA	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CHICK|Ensembl=ENSGALG00000028749|UniProtKB=Q5ZMQ2	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00019	Endothelin signaling pathway	P00583	cPLA2	MONDO|Ensembl=ENSMODG00000011791|UniProtKB=F7CBU9	Phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	CANLF|Gene=ADCY6|UniProtKB=P30804	Adenylate cyclase type 6	IGI	92409599	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00029	Huntington disease	P00805	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02726	Aminobutyrate degradation	P02825	4-aminobutyrate aminotransferase	SULSO|EnsemblGenome=SSO3211|UniProtKB=Q97U15	4-aminobutyrate aminotransferase (GabT-2)	ISS			PTHR11986:SF58	ALANINE--GLYOXYLATE AMINOTRANSFERASE 2, MITOCHONDRIAL
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	RAT|RGD=3693|UniProtKB=Q01818	Chromaffin granule amine transporter	ISS	12135927	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00034	Integrin signalling pathway	P00907	ERK	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	ISS			PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00010	B cell activation	P00385	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	HUMAN|HGNC=6093|UniProtKB=P14616	Insulin receptor-related protein	TAS	6754360	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02728	Arginine biosynthesis	P02848	N-acetylglutamate synthase	SCHPO|PomBase=SPBC725.14|UniProtKB=O94330	Amino-acid acetyltransferase, mitochondrial	ISS			PTHR23342:SF4	AMINO-ACID ACETYLTRANSFERASE, MITOCHONDRIAL
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	XENTR|Xenbase=XB-GENE-490883|UniProtKB=Q6NVA9	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01161	Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	HUMAN|HGNC=10483|UniProtKB=P21817	Ryanodine receptor 1	ISS	15226293	PubMed	PTHR13715:SF15	RYANODINE RECEPTOR 1
P00057	Wnt signaling pathway	P01453	Ebi	RAT|RGD=1563868|UniProtKB=G3V6G5	Protein Tbl1x	ISS	11389839	PubMed	PTHR22846:SF2	F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN TBL1X
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00049	Parkinson disease	P01238	14-3-3	MACMU|Ensembl=ENSMMUG00000013206|UniProtKB=F6XFG9	14-3-3 protein beta/alpha	ISS	12618428	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00010	B cell activation	P00376	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	BOVIN|Ensembl=ENSBTAG00000018445|UniProtKB=E1BK87	Uncharacterized protein	ISS	11554549	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P02751	Lysine biosynthesis	P03008	Dihydrodipicolinate synthase	BRADU|EnsemblGenome=BAC50337|UniProtKB=Q9RH76	4-hydroxy-tetrahydrodipicolinate synthase	ISS			PTHR12128:SF15	4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04395	Vasopressin synthesis	P04597	Signal Peptide	BOVIN|Ensembl=ENSBTAG00000008026|UniProtKB=P01175	Oxytocin-neurophysin 1	ISS	192340	OMIM	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	CAEEL|WormBase=WBGene00002173|UniProtKB=Q9Y0A1	Inositol 1,4,5-trisphosphate receptor itr-1	IC	4262086	gi	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00017	DNA replication	P00536	DNA Topisomerase	CANLF|Ensembl=ENSCAFG00000016090|UniProtKB=J9PAY8	DNA topoisomerase 2	ISS			PTHR10169:SF46	DNA TOPOISOMERASE 2-ALPHA
P00021	FGF signaling pathway	P00629	PP2A	NEUCR|EnsemblGenome=EFNCRG00000006348|UniProtKB=P48580	Serine/threonine-protein phosphatase PP2A catalytic subunit	ISS			PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00017	DNA replication	P00527	Histones	MACMU|Ensembl=ENSMMUG00000029868|UniProtKB=F7CPH7	Histone H3	ISS	12413958	PubMed	PTHR11426:SF161	HISTONE H3.2-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00857	IkappaB	MOUSE|MGI=MGI=104741|UniProtKB=Q9Z1E3	NF-kappa-B inhibitor alpha	ISS	12637573	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00029	Huntington disease	P00797	p53	CANLF|Gene=TP53|UniProtKB=Q29537	Cellular tumor antigen p53	TAS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00047	PDGF signaling pathway	P01150	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MOUSE|MGI=MGI=95774|UniProtKB=Q8CGK7	Guanine nucleotide-binding protein G(olf) subunit alpha	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00565	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	IGI	3045562	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00010	B cell activation	P00379	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04380	Cortocotropin releasing factor receptor signaling pathway	P04451	CRHR1	RAT|RGD=70547|UniProtKB=P47866	Corticotropin-releasing factor receptor 2	ISS	11145609	PubMed	PTHR12011:SF274	CORTICOTROPIN-RELEASING FACTOR RECEPTOR 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00633	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	BOVIN|Ensembl=ENSBTAG00000006326|UniProtKB=E1BDG9	10-formyltetrahydrofolate dehydrogenase	ISS			PTHR11699:SF131	MITOCHONDRIAL 10-FORMYLTETRAHYDROFOLATE DEHYDROGENASE
P04393	Ras Pathway	P04570	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00965	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00551	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01150	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00062	TH	HUMAN|HGNC=11782|UniProtKB=P07101	Tyrosine 3-monooxygenase	ISS	12480184	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00005	Angiogenesis	P00206	Wnt	MACMU|Ensembl=ENSMMUG00000000180|UniProtKB=F7HJM7	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00013	Cell cycle	P00483	Cyclin E	PANTR|Ensembl=ENSPTRG00000010782|UniProtKB=H2R677	Cyclin E1	ISS	12628165	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00053	T cell activation	P01312	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IDA	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00030	Hypoxia response via HIF activation	P00814	P300	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	IDA	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00018	EGF receptor signaling pathway	P00545	JNK1-3	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01067	AChE	HUMAN|HGNC=983|UniProtKB=P06276	Cholinesterase	IC			PTHR43918:SF5	CHOLINESTERASE
P00018	EGF receptor signaling pathway	P00558	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00053	T cell activation	P01312	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00059	p53 pathway	P01486	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	DANRE|ZFIN=ZDB-GENE-030131-2935|UniProtKB=Q8JIE4	Insulin-like growth factor 2	ISS	4504609	gi	PTHR11454:SF10	INSULIN-LIKE GROWTH FACTOR II
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=12774|UniProtKB=P04628	Proto-oncogene Wnt-1	IDA	14644163	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00019	Endothelin signaling pathway	P00590	IP3 R	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	IGI	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04393	Ras Pathway	P04552	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00017	DNA replication	P00529	RFC	HUMAN|HGNC=9973|UniProtKB=P40937	Replication factor C subunit 5	RCA			PTHR11669:SF9	REPLICATION FACTOR C SUBUNIT 5
P00003	Alzheimer disease-amyloid secretase pathway	P00094	BACE-1 pro-domain	BOVIN|Ensembl=ENSBTAG00000019365|UniProtKB=Q2HJ40	Beta-secretase 1	ISS	10956649	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IDA	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00053	T cell activation	P01305	Calmodulin	ORYSJ|EnsemblGenome=OS01G0267900|UniProtKB=Q0JNS6	Calmodulin-1	ISS	3885394	PubMed	PTHR23050:SF245	AT16150P-RELATED
P02738	De novo purine biosynthesis	P02908	Phosphoribosylamine glycine ligase	CAEEL|WormBase=WBGene00018174|UniProtKB=Q20143	Uncharacterized protein	ISS			PTHR43369:SF2	PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Gene=SSTR2|UniProtKB=P34993	Somatostatin receptor type 2	ISS	12562507	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P00013	Cell cycle	P00478	Pre-replication Complex	MACMU|Ensembl=ENSMMUG00000000854|UniProtKB=F6TGA8	Replication protein A 14 kDa subunit	ISS	8454588	PubMed	PTHR15114:SF1	REPLICATION PROTEIN A 14 KDA SUBUNIT
P05731	GABA-B receptor II signaling	P05754	Ggamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00058	mRNA splicing	P01476	U4	BOVIN|Gene=PRPF3|UniProtKB=Q2KIA6	U4/U6 small nuclear ribonucleoprotein Prp3	ISS	12875835	PubMed	PTHR14212:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CAEEL|WormBase=WBGene00001187|UniProtKB=Q8MQA1	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00260	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	MOUSE|MGI=MGI=109355|UniProtKB=O35526	Syntaxin-1A	ISS	1321498	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00034	Integrin signalling pathway	P00906	Rap1	XENTR|Xenbase=XB-GENE-479036|UniProtKB=Q640R7	Ras-related protein Rap-1b	ISS	1904317	PubMed	PTHR24070:SF382	RAS-RELATED PROTEIN RAP-1B
P02766	Phenylethylamine degradation	P03103	Phenylethylamine oxidase	MACMU|Ensembl=ENSMMUG00000020435|UniProtKB=F6TU01	Amine oxidase	ISS			PTHR10638:SF3	AMILORIDE-SENSITIVE AMINE OXIDASE  COPPER-CONTAINING
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00010	B cell activation	P00383	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IDA	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00019	Endothelin signaling pathway	P00591	PLCbeta	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Ensembl=ENSBTAG00000018989|UniProtKB=A5D7D8	GRM3 protein	ISS	12488551	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01408	Akt/PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CAEBR|Gene=CBG18112|UniProtKB=A8XT20	Protein CBR-GLR-1	ISS	8804111	PubMed	PTHR18966:SF297	GLUTAMATE RECEPTOR 1
P00029	Huntington disease	P00790	beta-Tubulin	CIOIN|Ensembl=ENSCING00000006957|UniProtKB=F6SYL0	Uncharacterized protein	ISS			PTHR11588:SF89	TUBULIN BETA-4 CHAIN
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	DROME|FlyBase=FBgn0037325|UniProtKB=Q7JWT4	AT15039p	IDA	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00048	PI3 kinase pathway	P01188	Gbetagamma	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00034	Integrin signalling pathway	P00948	Rho	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	IGI	12039949	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	20384797	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	XENTR|Xenbase=XB-GENE-977139|UniProtKB=F6RLA9	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF74	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA
P00049	Parkinson disease	P01211	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01465	Ggamma	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00029	Huntington disease	P00779	TBP	TETTS|EnsemblGenome=TTHERM_00575350|UniProtKB=Q22V65	TATA box-binding protein (TBP): present in archaea and protein	IPI	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00047	PDGF signaling pathway	P01161	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	ANOGA|EnsemblGenome=AGAP001478|UniProtKB=Q7PXM3	AGAP001478-PA	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IC	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	CANLF|Ensembl=ENSCAFG00000023094|UniProtKB=Q076A8	Developmental myosin heavy chain embryonic	ISS	89264452	PubMed	PTHR13140:SF427	MYOSIN-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=94925|UniProtKB=P30728	D(3) dopamine receptor	IDA	1319557	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	RAT|RGD=3696|UniProtKB=P51907	Excitatory amino acid transporter 3	ISS	96032356	PubMed	PTHR11958:SF69	EXCITATORY AMINO ACID TRANSPORTER 3
P00010	B cell activation	P00398	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IGI	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00010	B cell activation	P00376	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00018	EGF receptor signaling pathway	P00559	MEK1-2	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00029	Huntington disease	P00807	Actin	BOVIN|Gene=ACTG2|UniProtKB=Q5E9B5	Actin, gamma-enteric smooth muscle	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	YEAST|SGD=S000005565|UniProtKB=P38930	Casein kinase II subunit beta'	IDA	10617630	PubMed	PTHR11740:SF13	CASEIN KINASE II SUBUNIT BETA'
P00054	Toll receptor signaling pathway	P01368	MKK2	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	BOVIN|Ensembl=ENSBTAG00000007981|UniProtKB=P43249	G protein-coupled receptor kinase 5	RCA			PTHR24355:SF27	G PROTEIN-COUPLED RECEPTOR KINASE 5
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CHICK|Ensembl=ENSGALG00000011809|UniProtKB=F1NMB0	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IC	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	ISS	11319238	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00045	Notch signaling pathway	P01104	Serrate	CANLF|Ensembl=ENSCAFG00000005627|UniProtKB=E2QUR0	Delta-like protein	ISS	1286675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00018	EGF receptor signaling pathway	P00565	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	IGI	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00034	Integrin signalling pathway	P00948	Rho	ORNAN|Ensembl=ENSOANG00000008835|UniProtKB=F7FR08	Uncharacterized protein	ISS	13679859	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00047	PDGF signaling pathway	P01148	Grb2	MOUSE|MGI=MGI=1918770|UniProtKB=Q9CX99	GRB2-related adapter protein	ISS	8647802	PubMed	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P00021	FGF signaling pathway	P00626	Spry	MOUSE|MGI=MGI=1345144|UniProtKB=Q9WTP2	Protein sprouty homolog 4	ISS	22024232	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	ANOGA|Gene=AgaP_AGAP011360|UniProtKB=Q7Q2V9	AGAP011360-PA (Fragment)	IDA	4757780	gi	PTHR11792:SF17	KURTZ ARRESTIN
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	HUMAN|HGNC=1388|UniProtKB=O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	IDA	14624853	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00019	Endothelin signaling pathway	P00570	PKA	DICDI|dictyBase=DDB_G0283907|UniProtKB=P34099	cAMP-dependent protein kinase catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05912	Dopamine receptor mediated signaling pathway	P05964	GNAZ	HUMAN|HGNC=4395|UniProtKB=P19086	Guanine nucleotide-binding protein G(z) subunit alpha	RCA	16814816	PubMed	PTHR10218:SF65	GUANINE NUCLEOTIDE-BINDING PROTEIN G Z  SUBUNIT ALPHA
P04393	Ras Pathway	P04570	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IDA	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00029	Huntington disease	P00799	JNK-2	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00029	Huntington disease	P00775	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	14564011	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	DANRE|ZFIN=ZDB-GENE-000330-9|UniProtKB=Q90ZE4	Presenilin-2	TAS	12424519	PubMed	PTHR10202:SF13	PRESENILIN-2
P05915	Opioid proenkephalin pathway	P05994	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00034	Integrin signalling pathway	P00951	Jnk	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05917	Opioid proopiomelanocortin pathway	P06009	K+ channel	BOVIN|Ensembl=ENSBTAG00000047488|UniProtKB=G3N1D1	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00012	Cadherin signaling pathway	P00474	Wnt	CAEEL|WormBase=WBGene00001188|UniProtKB=G5EG05	Uncharacterized protein	IDA	11266476	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00012	Cadherin signaling pathway	P00462	Casein kinase II	DAPPU|EnsemblGenome=DAPPUDRAFT_223674|UniProtKB=E9GCV0	Putative uncharacterized protein	ISS	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00896	Insulin IGF	XENTR|Xenbase=XB-GENE-482586|UniProtKB=F6QUB0	Uncharacterized protein	ISS	4504609	gi	PTHR11454:SF10	INSULIN-LIKE GROWTH FACTOR II
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00018	EGF receptor signaling pathway	P00558	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00045	Notch signaling pathway	P01103	Next	ORNAN|Ensembl=ENSOANG00000008425|UniProtKB=F6VUQ4	Delta-like protein	ISS	8955070	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00019	Endothelin signaling pathway	P00591	PLCbeta	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00005	Angiogenesis	P00227	PLA2	BOVIN|Ensembl=ENSBTAG00000013298|UniProtKB=A4IFJ5	Cytosolic phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00025	Hedgehog signaling pathway	P00692	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	RAT|Ensembl=ENSRNOG00000059219|UniProtKB=A0A0G2K1F7	Protein Myo15a	ISS			PTHR13140:SF379	UNCONVENTIONAL MYOSIN-XV
P00057	Wnt signaling pathway	P01468	APC	PANTR|Ensembl=ENSPTRG00000017135|UniProtKB=H2QRB5	Adenomatous polyposis coli	ISS	12549854	PubMed	PTHR12607:SF11	ADENOMATOUS POLYPOSIS COLI PROTEIN
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00219	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00006	Apoptosis signaling pathway	P00314	MKK3	HUMAN|HGNC=6843|UniProtKB=P46734	Dual specificity mitogen-activated protein kinase kinase 3	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00059	p53 pathway	P04633	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	CANAL|CGD=CAL0072522|UniProtKB=Q59PM9	Serine hydroxymethyltransferase	ISS			PTHR11680:SF21	SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC
P02777	Succinate to proprionate conversion	P03163	Methylmalonyl-CoA decarboxylase	MYCTU|EnsemblGenome=LH57_20710|UniProtKB=O53578	Methylmalonyl-CoA carboxyltransferase	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P00048	PI3 kinase pathway	P01181	GSK3	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	THEMA|EnsemblGenome=TM_0943|UniProtKB=P36205	Glutamine synthetase	ISS			PTHR43785:SF1	TYPE-1 GLUTAMINE SYNTHETASE 2
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000006307|UniProtKB=H2SSM1	Uncharacterized protein	IC			PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P02760	PRPP biosynthesis	P03064	Phosphopentose mutase	ECOLI|EcoGene=EG12918|UniProtKB=P45549	Uncharacterized protein YhfW	ISS			PTHR21110:SF0	PHOSPHOPENTOMUTASE
P00019	Endothelin signaling pathway	P00581	Guanylate cyclase	PANTR|Ensembl=ENSPTRG00000016542|UniProtKB=H2QQC0	Uncharacterized protein	RCA			PTHR11920:SF318	GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-1
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	TAKRU|Ensembl=ENSTRUG00000011517|UniProtKB=H2TWL9	Uncharacterized protein (Fragment)	ISS	12497607	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00005	Angiogenesis	P00254	GTPase	MONDO|Ensembl=ENSMODG00000000981|UniProtKB=F7ES59	Uncharacterized protein	ISS	14871999	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MACMU|Ensembl=ENSMMUG00000006090|UniProtKB=F7B7V9	C-C chemokine receptor type 10	ISS	11821900	PubMed	PTHR10489:SF773	C-C CHEMOKINE RECEPTOR TYPE 10
P02755	Methylmalonyl pathway	P03034	Methylmalonyl-CoA mutase	THEKO|EnsemblGenome=TK1149|UniProtKB=Q5JIG4	Methylmalonyl-CoA mutase, N-terminus of large subunit	ISS			PTHR43589:SF2	SUBFAMILY NOT NAMED
P00020	FAS signaling pathway	P00607	Pro-Caspase6	XENTR|Xenbase=XB-GENE-482797|UniProtKB=F6R1R1	Uncharacterized protein	ISS	10770929	PubMed	PTHR10454:SF164	CASPASE-6
P00022	General transcription by RNA polymerase I	P00657	TBP	MOUSE|MGI=MGI=2684058|UniProtKB=Q6SJ95	TATA box-binding protein-like protein 2	ISS	600075	OMIM	PTHR10126:SF33	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 2
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00036	Interleukin signaling pathway	P00976	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00006	Apoptosis signaling pathway	P00318	PKCs	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	IDA	87218499	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00057	Wnt signaling pathway	P01465	Ggamma	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P02762	Pentose phosphate pathway	P03079	Hexokinase	PANTR|Ensembl=ENSPTRG00000002570|UniProtKB=H2Q205	Uncharacterized protein	RCA			PTHR19443:SF28	HEXOKINASE HKDC1-RELATED
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00644	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IGI	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00054	Toll receptor signaling pathway	P01358	ERK1	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00036	Interleukin signaling pathway	P00981	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000001583|UniProtKB=F7BBM1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	RAT|RGD=1305018|UniProtKB=D3ZF63	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	IDA	10974003	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00034	Integrin signalling pathway	P00928	alpha actinin	MONDO|Ensembl=ENSMODG00000008160|UniProtKB=F7EL30	Uncharacterized protein	ISS	2116421	PubMed	PTHR43947:SF6	ALPHA-ACTININ-3
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	MOUSE|MGI=MGI=1934950|UniProtKB=Q8BK63	Casein kinase I isoform alpha	ISS	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-070112-342|UniProtKB=A1L271	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=13829|UniProtKB=Q9GZT5	Protein Wnt-10a	IDA	11266476	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P05913	Enkephalin release	P05978	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	BOVIN|Ensembl=ENSBTAG00000020887|UniProtKB=F1MP22	Uncharacterized protein	ISS	14507926	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00019	Endothelin signaling pathway	P00587	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00022	General transcription by RNA polymerase I	P00649	TAF-IC	PANTR|Ensembl=ENSPTRG00000008411|UniProtKB=H2QBM1	Uncharacterized protein	ISS	20355009	PubMed	PTHR15319:SF1	TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT C
P00004	Alzheimer disease-presenilin pathway	P00141	Membrane metalloprotease	BOVIN|Ensembl=ENSBTAG00000012919|UniProtKB=F1MHG1	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF25	MATRIX METALLOPROTEINASE-15
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00878	INFgamma	MOUSE|MGI=MGI=107936|UniProtKB=P70380	Interleukin-18	IDA			PTHR45200:SF1	INTERLEUKIN-18
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04395	Vasopressin synthesis	P04592	Exopeptidase	MOUSE|MGI=MGI=101932|UniProtKB=Q00493	Carboxypeptidase E	ISS	1778303	PubMed	PTHR11532:SF59	CARBOXYPEPTIDASE E
P00010	B cell activation	P00371	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00976	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02773	S-adenosylmethionine biosynthesis	P03142	Cobalamin-dependent homocysteine transmethylase	RAT|RGD=621283|UniProtKB=Q9Z2Q4	Methionine synthase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	SULSO|EnsemblGenome=SSO2059|UniProtKB=Q97WQ9	Acetyl-CoA synthetase (Acetate-CoA ligase) (AcsA-6)	ISS			PTHR24095:SF232	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	7937853	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	RAT|RGD=1307994|UniProtKB=B6RK61	Myosin heavy chain 7B	ISS	10938134	PubMed	PTHR13140:SF358	MYOSIN-7B
P00004	Alzheimer disease-presenilin pathway	P00111	C99	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PHYPA|Gene=PHYPADRAFT_198730|UniProtKB=Q6TYS2	Actin 1	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00632	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00572	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00779	TBP	EMENI|EnsemblGenome=CADANIAG00005419|UniProtKB=Q12731	TATA-box-binding protein	IPI	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P02783	Tryptophan biosynthesis	P03209	Anthranilate phosphoribosyl transferase	NEUCR|EnsemblGenome=EFNCRG00000005105|UniProtKB=Q7RZ63	Anthranilate phosphoribosyltransferase	ISS			PTHR43285:SF2	ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE
P00012	Cadherin signaling pathway	P00474	Wnt	DANRE|ZFIN=ZDB-GENE-980526-526|UniProtKB=P24257	Protein Wnt-1	IDA	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	MACMU|Ensembl=ENSMMUG00000001498|UniProtKB=F7B5K3	Uncharacterized protein	ISS	12844405	PubMed	PTHR11644:SF2	CYTIDINE DEAMINASE
P04396	Vitamin D metabolism and pathway	P04605	P450 reductase	MOUSE|MGI=MGI=97744|UniProtKB=P37040	NADPH--cytochrome P450 reductase	TAS	2513880	PubMed	PTHR19384:SF17	NADPH--CYTOCHROME P450 REDUCTASE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00012	Cadherin signaling pathway	P00470	F-actin	MACMU|Ensembl=ENSMMUG00000009341|UniProtKB=F6UA54	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	IC	15737619	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00021	FGF signaling pathway	P00629	PP2A	TAKRU|Ensembl=ENSTRUG00000008018|UniProtKB=H2T5N4	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IGI	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	BOVIN|Ensembl=ENSBTAG00000000469|UniProtKB=P67774	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00219	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00005	Angiogenesis	P00224	PDGF	HUMAN|HGNC=8801|UniProtKB=Q9NRA1	Platelet-derived growth factor C	ISS			PTHR11633:SF5	PLATELET-DERIVED GROWTH FACTOR C
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04580	TRH Receptor	RAT|RGD=621262|UniProtKB=Q9R297	Thyrotropin releasing hormone receptor 2	ISS			PTHR24243:SF51	PROTEIN TRHR2
P00051	TCA cycle	P01268	Aconitase	BOVIN|Ensembl=ENSBTAG00000006429|UniProtKB=P20004	Aconitate hydratase, mitochondrial	RCA			PTHR43160:SF3	ACONITATE HYDRATASE, MITOCHONDRIAL
P00025	Hedgehog signaling pathway	P00693	Ubiquitin ligase	DANRE|ZFIN=ZDB-GENE-030131-6559|UniProtKB=F1QT71	Uncharacterized protein	ISS			PTHR11254:SF402	E3 UBIQUITIN-PROTEIN LIGASE UBR5
P02766	Phenylethylamine degradation	P03103	Phenylethylamine oxidase	SCHPO|PomBase=SPBC1289.16c|UniProtKB=O42890	Copper amine oxidase-like protein cao2	ISS			PTHR10638:SF41	AMINE OXIDASE
P00011	Blood coagulation	P00418	Fibrin monomer	MACMU|Ensembl=ENSMMUG00000021304|UniProtKB=F6UYY8	Uncharacterized protein	ISS	80015086	PubMed	PTHR19143:SF338	FIBRINOGEN GAMMA CHAIN
P00008	Axon guidance mediated by Slit/Robo	P00344	Netrin	PANTR|Ensembl=ENSPTRG00000005315|UniProtKB=H2Q6M9	Uncharacterized protein	ISS	2538453	PubMed	PTHR10574:SF282	NETRIN-4
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	IDA	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	MYCTU|EnsemblGenome=Rv3048c|UniProtKB=P9WH71	Ribonucleoside-diphosphate reductase subunit beta nrdF2	ISS			PTHR23409:SF32	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT BETA
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	YEAST|SGD=S000000028|UniProtKB=P31109	Synaptobrevin homolog 1	IC			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	TAKRU|Ensembl=ENSTRUG00000012143|UniProtKB=H2U1C0	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P02775	Salvage pyrimidine ribonucleotides	P03153	Cytidylate kinase	MACMU|Ensembl=ENSMMUG00000007151|UniProtKB=F7DMM9	UMP-CMP kinase	ISS			PTHR23359:SF107	UMP-CMP KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02920	dCTP deaminase	METJA|EnsemblGenome=MJ_0430|UniProtKB=Q57872	dCTP deaminase, dUMP-forming	RCA			PTHR42680:SF3	DCTP DEAMINASE
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IC	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00035	Interferon-gamma signaling pathway	P00956	SOCS	RAT|RGD=1306503|UniProtKB=B5DF08	Protein Socs4	ISS	15032587	PubMed	PTHR44282:SF2	SUPPRESSOR OF CYTOKINE SIGNALING 4
P00034	Integrin signalling pathway	P00919	Arf6	CANLF|Ensembl=ENSCAFG00000024150|UniProtKB=E2RHL4	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CHICK|Ensembl=ENSGALG00000014620|UniProtKB=F1N8P3	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02754	Methylcitrate cycle	P03028	Aconitase	BOVIN|Ensembl=ENSBTAG00000002504|UniProtKB=E1BNR2	Uncharacterized protein	ISS			PTHR11670:SF31	IRON-RESPONSIVE ELEMENT-BINDING PROTEIN 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00223	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00034	Integrin signalling pathway	P00922	Collagen	MACMU|Ensembl=ENSMMUG00000005577|UniProtKB=F7G4G7	Uncharacterized protein	ISS	10778855	PubMed	PTHR44652:SF3	COLLAGEN ALPHA-1 IX  CHAIN
P00018	EGF receptor signaling pathway	P00546	GAP	PANTR|Ensembl=ENSPTRG00000008970|UniProtKB=H2QCM0	Neurofibromin 1	ISS	8982875	PubMed	PTHR10194:SF60	NEUROFIBROMIN
P00019	Endothelin signaling pathway	P00566	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00589	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	MOUSE|MGI=MGI=99473|UniProtKB=Q8BWG8	Beta-arrestin-1	ISS	9388255	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00034	Integrin signalling pathway	P00921	PINCH	CANLF|Ensembl=ENSCAFG00000002015|UniProtKB=E2RKQ1	Uncharacterized protein	ISS	10022929	PubMed	PTHR24210:SF11	LIM AND SENESCENT CELL ANTIGEN-LIKE-CONTAINING DOMAIN PROTEIN 1-RELATED
P02771	Pyrimidine Metabolism	P03128	Dihydrouracil Dehydrogenase	MACMU|Ensembl=ENSMMUG00000020726|UniProtKB=F7GVE2	Uncharacterized protein	ISS	8083224	PubMed	PTHR43073:SF2	DIHYDROPYRIMIDINE DEHYDROGENASE  NADP +
P00056	VEGF signaling pathway	P01407	Erk	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01417	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06812	L-type Ca2+	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	RCA	10514528	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00036	Interleukin signaling pathway	P00970	Interleukin	MOUSE|MGI=MGI=96559|UniProtKB=P08505	Interleukin-6	IC	12014193	PubMed	PTHR45110:SF1	INTERLEUKIN-6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	TAKRU|Ensembl=ENSTRUG00000014419|UniProtKB=H2UIU6	Uncharacterized protein	ISS	10940259	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00057	Wnt signaling pathway	P01428	Frizzled	BOVIN|Ensembl=ENSBTAG00000010529|UniProtKB=F1MP23	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF75	FRIZZLED-6
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	PANTR|Ensembl=ENSPTRG00000006342|UniProtKB=H2Q8A8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	IC	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	TAS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04396	Vitamin D metabolism and pathway	P04600	DBP	PANTR|Ensembl=ENSPTRG00000016143|UniProtKB=H2QPM5	Glucosylceramidase	ISS	11799400	PubMed	PTHR11385:SF11	VITAMIN D-BINDING PROTEIN
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	NEUCR|EnsemblGenome=EFNCRG00000004408|UniProtKB=P00369	NADP-specific glutamate dehydrogenase	ISS			PTHR43571:SF1	NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED
P00047	PDGF signaling pathway	P01148	Grb2	BOVIN|Ensembl=ENSBTAG00000003707|UniProtKB=A6QLK6	GRB2-related adapter protein	ISS	9741627	PubMed	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04393	Ras Pathway	P04557	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	IDA	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00059	p53 pathway	G01574	ARF	BOVIN|Gene=CDKN2B|UniProtKB=Q2KJD8	Cyclin-dependent kinase 4 inhibitor B	ISS			PTHR24148:SF47	CYCLIN-DEPENDENT KINASE 4 INHIBITOR B-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	DANRE|ZFIN=ZDB-GENE-030131-8013|UniProtKB=F1QBT6	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MOUSE|MGI=MGI=102522|UniProtKB=Q8R3Z5	Voltage-dependent L-type calcium channel subunit beta-1	IDA	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00038	JAK/STAT signaling pathway	P01029	Serine kinase	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	ISS			PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	94280860	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05913	Enkephalin release	P05977	G-Protein (s)	ANOGA|EnsemblGenome=AGAP005912|UniProtKB=Q7Q6D3	AGAP005912-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	TAS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=620656|UniProtKB=O88277	Protocadherin Fat 2	IDA	8120095	PubMed	PTHR24026:SF37	PROTOCADHERIN FAT 2
P00020	FAS signaling pathway	P00615	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02736	Coenzyme A biosynthesis	P02884	Dephospho-CoA kinase	RAT|RGD=1359211|UniProtKB=Q6AY55	Dephospho-CoA kinase domain-containing protein	ISS			PTHR10695:SF35	DEPHOSPHO-COA KINASE DOMAIN-CONTAINING PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00054	Toll receptor signaling pathway	P01352	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P02774	Salvage pyrimidine deoxyribonucleotides	P03147	Thymidine kinase	BACSU|EnsemblGenome=BSU37060|UniProtKB=Q03221	Thymidine kinase	ISS			PTHR11441:SF0	THYMIDINE KINASE, CYTOSOLIC
P04393	Ras Pathway	P04556	Raf	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS	12068308	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00890	ELK	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	11151091	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	HUMAN|HGNC=4403|UniProtKB=P61952	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	RCA	2122451	PubMed	PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P00057	Wnt signaling pathway	P01437	TCF	RAT|RGD=620241|UniProtKB=Q9QXN1	Lymphoid enhancer-binding factor 1	IDA	9039917	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00053	T cell activation	P01324	rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	8649368	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ORNAN|Ensembl=ENSOANG00000007716|UniProtKB=F6UDX9	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00018	EGF receptor signaling pathway	P00557	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	TAKRU|Ensembl=ENSTRUG00000000172|UniProtKB=H2RJP1	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF103	PROTEIN WNT-4A
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	PANTR|Ensembl=ENSPTRG00000011719|UniProtKB=H2QHJ6	Uncharacterized protein	ISS			PTHR24073:SF269	DNAJ HOMOLOG SUBFAMILY C MEMBER 27
P00034	Integrin signalling pathway	P00927	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04393	Ras Pathway	P04547	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P00047	PDGF signaling pathway	P01153	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04372	5-Hydroxytryptamine degredation	P04401	Monoamine Oxidase	HUMAN|HGNC=19094|UniProtKB=Q96RQ9	L-amino-acid oxidase	ISS			PTHR10742:SF21	L-AMINO-ACID OXIDASE
P00006	Apoptosis signaling pathway	P00274	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	CANLF|Ensembl=ENSCAFG00000030049|UniProtKB=J9NWQ5	Uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF311	CALMODULIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DANRE|ZFIN=ZDB-GENE-041210-195|UniProtKB=F1R506	Protein kinase C	ISS	11880265	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	RCA	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00562	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00036	Interleukin signaling pathway	P00974	Receptor subunit beta	HUMAN|HGNC=5965|UniProtKB=Q08334	Interleukin-10 receptor subunit beta	ISS			PTHR20859:SF50	INTERLEUKIN-10 RECEPTOR SUBUNIT BETA
P00019	Endothelin signaling pathway	P00589	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DICPU|Gene=DICPUDRAFT_48914|UniProtKB=F0ZK40	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF154	ACTIN-17-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00029	Huntington disease	P00780	Microtubule	BOVIN|Ensembl=ENSBTAG00000004093|UniProtKB=Q6B856	Tubulin beta-2B chain	ISS	9454836	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P06959	CCKR signaling map	P07153	RSK1/2	HUMAN|HGNC=10430|UniProtKB=Q15418	Ribosomal protein S6 kinase alpha-1	RCA	18813292	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00005	Angiogenesis	P00193	SOS-1	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000001187|UniProtKB=F6R8N9	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P04393	Ras Pathway	P04547	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	PANTR|Gene=CHRM5|UniProtKB=Q5IS53	Muscarinic acetylcholine receptor M5	ISS	8100450	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00007	Axon guidance mediated by semaphorins	P00331	PAK	RAT|RGD=3250|UniProtKB=P35465	Serine/threonine-protein kinase PAK 1	ISS	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00005	Angiogenesis	P00193	SOS-1	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	YEAST|SGD=S000006258|UniProtKB=P41808	Sporulation-specific mitogen-activated protein kinase SMK1	ISS			PTHR24055:SF198	SPORULATION-SPECIFIC MITOGEN-ACTIVATED PROTEIN KINASE SMK1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00163	Erb-B4 C-terminal fragment	MACMU|Ensembl=ENSMMUG00000001674|UniProtKB=F7G3H1	Receptor protein-tyrosine kinase	ISS	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00056	VEGF signaling pathway	P01411	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=18539|UniProtKB=P61266	Syntaxin-1B	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00047	PDGF signaling pathway	P01167	Ets	PANTR|Ensembl=ENSPTRG00000013907|UniProtKB=H2RE26	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF216	TRANSCRIPTIONAL REGULATOR ERG
P00005	Angiogenesis	P00210	eNOS	CANLF|Gene=NOS3|UniProtKB=Q9TUX8	Nitric oxide synthase, endothelial	ISS	22462730	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00019	Endothelin signaling pathway	P00566	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	MOUSE|MGI=MGI=1321159|UniProtKB=P63330	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=98960|UniProtKB=P22727	Protein Wnt-6	IDA	11266476	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P00034	Integrin signalling pathway	P00947	Laminin	PANTR|Ensembl=ENSPTRG00000023820|UniProtKB=H2R041	Uncharacterized protein	ISS	2538453	PubMed	PTHR10574:SF268	LAMININ SUBUNIT BETA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00021	FGF signaling pathway	P00644	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	MACMU|Ensembl=ENSMMUG00000022513|UniProtKB=F6YNZ0	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00029	Huntington disease	P00774	Dynein complex	STRPU|EnsemblGenome=SPU_024497|UniProtKB=W4Z8M3	Uncharacterized protein	ISS	9454836	PubMed	PTHR11886:SF35	DYNEIN LIGHT CHAIN 2, CYTOPLASMIC
P04380	Cortocotropin releasing factor receptor signaling pathway	P04455	beta-endorphin	MOUSE|MGI=MGI=97742|UniProtKB=P01193	Pro-opiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00021	FGF signaling pathway	P00629	PP2A	BOVIN|Ensembl=ENSBTAG00000001862|UniProtKB=Q5E9Q7	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform	ISS	1849734	PubMed	PTHR11871:SF1	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	USTMA|Gene=UMAG_04456|UniProtKB=A0A0D1DSN6	Chromosome 14, whole genome shotgun sequence	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00029	Huntington disease	P00790	beta-Tubulin	MACMU|Ensembl=ENSMMUG00000029059|UniProtKB=F6QAX2	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MONDO|Ensembl=ENSMODG00000017165|UniProtKB=F6QDH4	Uncharacterized protein	ISS	22213672	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	TAS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	DROME|FlyBase=FBgn0010399|UniProtKB=Q24418	Glutamate [NMDA] receptor subunit 1	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CAEEL|WormBase=WBGene00001617|UniProtKB=Q8MXV8	GLutamate Receptor family (AMPA)	IC	12941441	PubMed	PTHR18966:SF295	GLUTAMATE RECEPTOR FAMILY  AMPA
P00057	Wnt signaling pathway	P01428	Frizzled	XENTR|Xenbase=XB-GENE-479707|UniProtKB=F6QAW3	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF126	FRIZZLED-5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	DROME|FlyBase=FBgn0024814|UniProtKB=Q9VWA1	Clathrin light chain	IDA	9388255	PubMed	PTHR10639:SF7	CLATHRIN LIGHT CHAIN
P00020	FAS signaling pathway	P00610	MKK4	MACMU|Ensembl=ENSMMUG00000019842|UniProtKB=F7FU91	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	MOUSE|MGI=MGI=88296|UniProtKB=O55017	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	14624853	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	BOVIN|Ensembl=ENSBTAG00000019338|UniProtKB=G3X7E9	Uncharacterized protein	IEP	10614495	PubMed	PTHR23036:SF89	INTERLEUKIN-13 RECEPTOR SUBUNIT ALPHA-1
P00020	FAS signaling pathway	P00615	JNK	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	TAS	7600581	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00029	Huntington disease	P00807	Actin	PHYIT|EnsemblGenome=PITG_15078|UniProtKB=D0NRL5	Actin-like protein	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00776	c-Jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00754	PDEgamma	MOUSE|MGI=MGI=97526|UniProtKB=P09174	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	TAS	P09174	SPACC	PTHR12122:SF4	RETINAL ROD RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT GAMMA
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05912	Dopamine receptor mediated signaling pathway	P05961	DOPA decarb.	RAT|RGD=2494|UniProtKB=P14173	Aromatic-L-amino-acid decarboxylase	ISS	90339966	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CAEBR|Gene=CBG05896|UniProtKB=A8X1E0	Phosphoinositide phospholipase C	ISS			PTHR10336:SF147	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-2
P00049	Parkinson disease	P01227	20S proteasome	ORYSJ|EnsemblGenome=OS01G0811100|UniProtKB=Q9LSU0	Proteasome subunit alpha type-3	TAS	12859888	PubMed	PTHR11599:SF10	PROTEASOME SUBUNIT ALPHA TYPE-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00010	B cell activation	P00383	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	XENTR|Xenbase=XB-GENE-976753|UniProtKB=Q0VFR6	Syntaxin 1A (Brain)	ISS	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00920	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04393	Ras Pathway	P04542	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P02779	Thiamin biosynthesis	P03170	Hydroxymethylpyrimidine phosphate kinase	FUSNN|EnsemblGenome=FN1759|UniProtKB=Q8RI58	Phosphomethylpyrimidine kinase	ISS			PTHR20858:SF17	HYDROXYMETHYLPYRIMIDINE/PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED
P00005	Angiogenesis	P00226	Delta/Serrate	PANTR|Ensembl=ENSPTRG00000013250|UniProtKB=H2QJZ0	Delta-like protein	ISS	8955070	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01082	AC	HUMAN|HGNC=21285|UniProtKB=Q96PN6	Adenylate cyclase type 10	IC	10915626	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00019	Endothelin signaling pathway	P00585	ECE1-3	CAEEL|WormBase=WBGene00011794|UniProtKB=Q22523	Neprilysin-21	ISS			PTHR11733:SF192	NEPRILYSIN-21
P00020	FAS signaling pathway	P00620	CytochromeC	MACMU|Ensembl=ENSMMUG00000007149|UniProtKB=F7DMP6	Uncharacterized protein	ISS	15163634	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00057	Wnt signaling pathway	P01443	Phospholipase C	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00004	Alzheimer disease-presenilin pathway	P00110	Ire-1 N-terminal fragment	MOUSE|MGI=MGI=1349436|UniProtKB=Q9Z2E3	Serine/threonine-protein kinase/endoribonuclease IRE2	IDA	10619423	PubMed	PTHR13954:SF15	SERINE/THREONINE-PROTEIN KINASE/ENDORIBONUCLEASE IRE2
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	PANTR|Ensembl=ENSPTRG00000023608|UniProtKB=H2QZZ2	Uncharacterized protein	ISS	14698601	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P05731	GABA-B receptor II signaling	P05755	Gbeta	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00047	PDGF signaling pathway	P01161	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00819	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	YEAST|SGD=S000005854|UniProtKB=P33328	Synaptobrevin homolog 2	ISS			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00053	T cell activation	P01320	PLC-gamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	HUMAN|HGNC=4383|UniProtKB=P30679	Guanine nucleotide-binding protein subunit alpha-15	IDA	8838318	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P00005	Angiogenesis	P00223	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P02772	Pyruvate metabolism	P03140	Pyruvate Carboxylase	YEAST|SGD=S000003030|UniProtKB=P11154	Pyruvate carboxylase 1	IDA	1921979	PubMed	PTHR43778:SF2	PYRUVATE CARBOXYLASE, MITOCHONDRIAL
P04398	p53 pathway feedback loops 2	P04651	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04393	Ras Pathway	P04550	Ral	DANRE|ZFIN=ZDB-GENE-041114-195|UniProtKB=Q5U3A3	Uncharacterized protein	ISS			PTHR24070:SF174	RAS-RELATED PROTEIN RAL-A
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00047	PDGF signaling pathway	P01151	PKB	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014262|UniProtKB=F7BYS8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05731	GABA-B receptor II signaling	P05760	AC	XENTR|Xenbase=XB-GENE-999257|UniProtKB=F7CEX4	Uncharacterized protein	ISS	97228584	PubMed	PTHR11920:SF319	ADENYLATE CYCLASE TYPE 9
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02768	Proline biosynthesis	P03114	Glutamyl kinase	AQUAE|EnsemblGenome=aq_1134|UniProtKB=O67209	Glutamate 5-kinase	ISS			PTHR43654:SF3	GLUTAMATE 5-KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	PANTR|Ensembl=ENSPTRG00000007084|UniProtKB=H2Q9G5	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00010	B cell activation	P00391	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00551	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IGI	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	CHICK|Ensembl=ENSGALG00000008512|UniProtKB=F1P0S6	Uncharacterized protein	ISS	20112749	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00057	Wnt signaling pathway	P01438	PP2A	RAT|RGD=6503701|UniProtKB=F1MAA3	Protein LOC100909464	ISS	10092233	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CANLF|Ensembl=ENSCAFG00000005291|UniProtKB=E2QXQ3	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=94926|UniProtKB=P51436	D(4) dopamine receptor	IDA	11248120	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	ISS	6319455	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02785	Valine biosynthesis	P03215	Branched chain amino acid aminotransferase	ARATH|TAIR=AT3G49680|UniProtKB=Q9M401	Branched-chain-amino-acid aminotransferase 3, chloroplastic	ISS			PTHR42825:SF2	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 3, CHLOROPLASTIC
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00053	T cell activation	P01312	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=1306541|UniProtKB=D3ZVF3	Phosphoinositide-3-kinase, class 2, beta polypeptide (Predicted)	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00030	Hypoxia response via HIF activation	P00819	AKT	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	TAS	12655147	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P06002	G-protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	BOVIN|Ensembl=ENSBTAG00000047202|UniProtKB=G3N3K3	Uncharacterized protein	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MONDO|Ensembl=ENSMODG00000014746|UniProtKB=F6YN64	Uncharacterized protein (Fragment)	ISS	12497607	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00792	SEK-1	MOUSE|MGI=MGI=1346869|UniProtKB=P47809	Dual specificity mitogen-activated protein kinase kinase 4	RCA			PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	XENTR|GeneID=394982|UniProtKB=P20399	Actin, alpha cardiac muscle 2	ISS	11889139	PubMed	PTHR11937:SF263	ACTIN
P00029	Huntington disease	P00786	ARF	ANOGA|EnsemblGenome=AGAP011730|UniProtKB=Q7PZ49	AGAP011730-PA (Fragment)	ISS	12932731	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P00029	Huntington disease	P00805	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=12779|UniProtKB=O14905	Protein Wnt-9b	IDA	8717036	PubMed	PTHR12027:SF84	PROTEIN WNT-9B
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	NEUCR|EnsemblGenome=EFNCRG00000001037|UniProtKB=Q7SE08	Phosphoinositide phospholipase C	ISS			PTHR10336:SF82	SUBFAMILY NOT NAMED
P00010	B cell activation	P00398	IP3R	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	IGI	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00017	DNA replication	P00527	Histones	THAPS|Gene=Thaps29950|UniProtKB=B8CC53	Histone H3	ISS	20448842	PubMed	PTHR11426:SF101	HISTONE H3-LIKE CENTROMERIC PROTEIN CID
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	ORNAN|Ensembl=ENSOANG00000007488|UniProtKB=F6RH86	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF317	MYOSIN-9
P00047	PDGF signaling pathway	P01168	PI3K	ARATH|TAIR=AT1G60490|UniProtKB=P42339	Phosphatidylinositol 3-kinase VPS34	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IGI	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01336	Jnk	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00023	General transcription regulation	P00658	TBP-associated factors	HUMAN|HGNC=17300|UniProtKB=Q7Z7C8	Transcription initiation factor TFIID subunit 8	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Ensembl=ENSPTRG00000004233|UniProtKB=H2Q4N9	Uncharacterized protein	ISS	12497607	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00059	p53 pathway	P04609	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05924	AT1-R	PANTR|Ensembl=ENSPTRG00000015503|UniProtKB=Q9GLN9	Type-1 angiotensin II receptor	RCA			PTHR24228:SF11	TYPE-1 ANGIOTENSIN II RECEPTOR
P00036	Interleukin signaling pathway	P00996	STAT	HUMAN|HGNC=11367|UniProtKB=P51692	Signal transducer and activator of transcription 5B	IDA	8732682	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P06664	Gonadotropin-releasing hormone receptor pathway	G06686	COX2	MOUSE|MGI=MGI=102503|UniProtKB=P00405	Cytochrome c oxidase subunit 2	RCA			PTHR22888:SF9	CYTOCHROME C OXIDASE SUBUNIT 2
P05734	Synaptic vesicle trafficking	P05778	SNAP-25	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	TAS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BRAFL|Gene=BRAFLDRAFT_118309|UniProtKB=C3YZ17	Protein Wnt	TAS	11266476	PubMed	PTHR12027:SF100	SUBFAMILY NOT NAMED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DICDI|dictyBase=DDB_G0283907|UniProtKB=P34099	cAMP-dependent protein kinase catalytic subunit	IC	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000024992|UniProtKB=F6TUR3	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00049	Parkinson disease	P01208	Hsp70	THEMA|EnsemblGenome=TM_0373|UniProtKB=Q9WYK6	Chaperone protein DnaK	IDA	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P00057	Wnt signaling pathway	P01443	Phospholipase C	DROME|FlyBase=FBgn0004611|UniProtKB=P25455	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II	IDA	10934033	PubMed	PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P04393	Ras Pathway	P04541	p90RSK	CHICK|Ensembl=ENSGALG00000011473|UniProtKB=F1P1H2	Ribosomal protein S6 kinase	ISS	1922062	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05931	EGR	CANLF|Ensembl=ENSCAFG00000001254|UniProtKB=E2RBP5	Early growth response protein	ISS			PTHR44685:SF1	EARLY GROWTH RESPONSE PROTEIN 1
P00053	T cell activation	P01311	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00060	Ubiquitin proteasome pathway	P01492	E1	MACMU|Ensembl=ENSMMUG00000021804|UniProtKB=F7ESQ7	Ubiquitin-like modifier-activating enzyme ATG7 isoform a	ISS			PTHR10953:SF3	UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MACMU|Ensembl=ENSMMUG00000000602|UniProtKB=F7C827	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF144	REGULATOR OF G-PROTEIN SIGNALING 11
P00048	PI3 kinase pathway	P01188	Gbetagamma	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	IC	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IGI	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04393	Ras Pathway	P04543	MEKK1/4	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS	97236778	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	PANTR|Ensembl=ENSPTRG00000001757|UniProtKB=H2Q0Q8	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF147	REGULATOR OF G-PROTEIN SIGNALING 8
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=2443588|UniProtKB=Q5SW28	Phosphoinositide 3-kinase regulatory subunit 5	ISS			PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05916	Opioid prodynorphin pathway	P06001	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04393	Ras Pathway	P04559	Rac	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS	12606638	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=98956|UniProtKB=P27467	Protein Wnt-3a	TAS	8717036	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	14765990	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05915	Opioid proenkephalin pathway	P05994	G-protein	CHICK|Ensembl=ENSGALG00000001334|UniProtKB=F1NLV4	Uncharacterized protein	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	HUMAN|HGNC=6692|UniProtKB=Q07954	Prolow-density lipoprotein receptor-related protein 1	IDA	11907044	PubMed	PTHR44025:SF2	PROLOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1
P00057	Wnt signaling pathway	P01451	Galpha	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00004	Alzheimer disease-presenilin pathway	P00149	Pen-2	ANOGA|EnsemblGenome=AGAP008094|UniProtKB=Q7Q3Y1	AGAP008094-PA	IDA	12110170	PubMed	PTHR16318:SF0	GAMMA-SECRETASE SUBUNIT PEN-2
P00001	Adrenaline and noradrenaline biosynthesis	P00064	NET	MACMU|Ensembl=ENSMMUG00000020238|UniProtKB=F6UT22	Transporter	ISS	97248649	PubMed	PTHR11616:SF37	SODIUM-DEPENDENT NORADRENALINE TRANSPORTER
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00007	Axon guidance mediated by semaphorins	P00332	Fes	PANTR|Ensembl=ENSPTRG00000007462|UniProtKB=H2QA35	Tyrosine-protein kinase	ISS			PTHR24418:SF197	TYROSINE-PROTEIN KINASE FES/FPS
P00015	Circadian clock system	G01504	bmal1	DANRE|ZFIN=ZDB-GENE-000509-1|UniProtKB=Q9I879	Bmal1	ISS			PTHR23042:SF52	ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 1
P00030	Hypoxia response via HIF activation	P00819	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	TAS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00020	FAS signaling pathway	P00615	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000011466|UniProtKB=F7B2R8	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01082	AC	HUMAN|HGNC=21285|UniProtKB=Q96PN6	Adenylate cyclase type 10	IC	11744988	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P00057	Wnt signaling pathway	P01444	Wnt	CHICK|Ensembl=ENSGALG00000005123|UniProtKB=Q9DEB8	Protein Wnt	IDA	11266476	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_114958|UniProtKB=C3XZ13	Putative uncharacterized protein	ISS			PTHR11937:SF359	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00059	p53 pathway	G04702	p53	CHICK|Ensembl=ENSGALG00000007324|UniProtKB=F1N8Z7	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05918	p38 MAPK pathway	P06025	SRF	PANTR|Ensembl=ENSPTRG00000018189|UniProtKB=H2QT21	Uncharacterized protein	ISS	15647354	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00057	Wnt signaling pathway	P01443	Phospholipase C	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00052	TGF-beta signaling pathway	P01275	P38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00029	Huntington disease	P00786	ARF	CANLF|Ensembl=ENSCAFG00000014581|UniProtKB=E2R9P6	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF137	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 4D
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01300	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	HUMAN|HGNC=9509|UniProtKB=P49810	Presenilin-2	IDA	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	TAS			PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CAEEL|WormBase=WBGene00001187|UniProtKB=Q8MQA1	Uncharacterized protein	IC	9199552	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	RCA	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00059	p53 pathway	P04633	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P00999	PSD95	MOUSE|MGI=MGI=2671987|UniProtKB=Q80Z38	SH3 and multiple ankyrin repeat domains protein 2	ISS	20020275	PubMed	PTHR24135:SF17	SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN 2
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	LEIMA|EnsemblGenome=LmjF.35.0820|UniProtKB=Q4FX34	Aspartate aminotransferase	ISS			PTHR11879:SF22	ASPARTATE AMINOTRANSFERASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00059	p53 pathway	P01483	Mdm2	DANRE|ZFIN=ZDB-GENE-990415-153|UniProtKB=O42354	E3 ubiquitin-protein ligase Mdm2	IGI	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00053	T cell activation	P01300	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	BOVIN|Ensembl=ENSBTAG00000019269|UniProtKB=F1MKG2	Uncharacterized protein	ISS	10778855	PubMed	PTHR44172:SF1	COLLAGEN ALPHA-2 VI  CHAIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	BOVIN|Ensembl=ENSBTAG00000035697|UniProtKB=Q28024	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IDA			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00053	T cell activation	P01306	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02738	De novo purine biosynthesis	P02909	GDP reductase	BOVIN|Ensembl=ENSBTAG00000008216|UniProtKB=E1BI58	Uncharacterized protein	ISS			PTHR23409:SF20	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	MACMU|Ensembl=ENSMMUG00000000983|UniProtKB=F6SYL4	Fructose-bisphosphate aldolase	ISS	84261525	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00057	Wnt signaling pathway	P01452	NFAT	RAT|RGD=1310749|UniProtKB=D3Z9H7	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	ISS	9133421	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P04393	Ras Pathway	P04558	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	HUMAN|HGNC=129|UniProtKB=P68133	Actin, alpha skeletal muscle	IC	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P02762	Pentose phosphate pathway	P03079	Hexokinase	RAT|RGD=2321830|UniProtKB=M0R3X7	Protein LOC100364027	RCA			PTHR19443:SF28	HEXOKINASE HKDC1-RELATED
P00010	B cell activation	P00369	MEKK	RAT|RGD=1304575|UniProtKB=B5DF98	Map3k3 protein	ISS	9006902	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00034	Integrin signalling pathway	P00924	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IPI	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IDA	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00057	Wnt signaling pathway	P01444	Wnt	MACMU|Ensembl=ENSMMUG00000015705|UniProtKB=F6SM00	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00050	Plasminogen activating cascade	P01251	MMP-3	MOUSE|MGI=MGI=97010|UniProtKB=P28862	Stromelysin-1	ISS	3875482	PubMed	PTHR10201:SF215	STROMELYSIN-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00182	p38MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00029	Huntington disease	P00777	CBP	CAEEL|WormBase=WBGene00000366|UniProtKB=P34545	Protein cbp-1	IDA	10769018	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	DROME|FlyBase=FBgn0032859|UniProtKB=Q9VIM5	Actin-related protein 2/3 complex subunit 2	ISS	17943202	gi	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000012820|UniProtKB=F1MDL3	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00034	Integrin signalling pathway	P00927	Rac	ENTHI|EnsemblGenome=EHI_181250|UniProtKB=C4M5Z7	Rho family GTPase	IGI	4757952	gi	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P04393	Ras Pathway	P04542	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00048	PI3 kinase pathway	P01179	PKB	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	CANLF|Ensembl=ENSCAFG00000009203|UniProtKB=F1PVZ1	Muscarinic acetylcholine receptor	ISS	10069496	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00010	B cell activation	P00401	jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06777	NFAT	MOUSE|MGI=MGI=103296|UniProtKB=P97305	Nuclear factor of activated T-cells, cytoplasmic 3	RCA	12015605	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00046	Oxidative stress response	P01131	MKP5	ORNAN|Ensembl=ENSOANG00000007135|UniProtKB=F6PUA3	Uncharacterized protein	ISS			PTHR10159:SF338	DUAL SPECIFICITY PROTEIN PHOSPHATASE 14
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05731	GABA-B receptor II signaling	P05754	Ggamma	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00049	Parkinson disease	P01238	14-3-3	XENTR|Xenbase=XB-GENE-970616|UniProtKB=Q6P4Z5	14-3-3 protein zeta	ISS	12615066	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00012	Cadherin signaling pathway	P00474	Wnt	RAT|RGD=1304988|UniProtKB=A0A0G2K6Q8	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04393	Ras Pathway	P04542	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00623	FGF	MACMU|Ensembl=ENSMMUG00000002969|UniProtKB=F7GXY3	Fibroblast growth factor	ISS			PTHR11486:SF26	FIBROBLAST GROWTH FACTOR 3
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00054	Toll receptor signaling pathway	P01375	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01417	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04580	TRH Receptor	RAT|RGD=3904|UniProtKB=Q01717	Thyrotropin-releasing hormone receptor	ISS	14599121	PubMed	PTHR24243:SF115	THYROTROPIN-RELEASING HORMONE RECEPTOR
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00029	Huntington disease	G01535	PIG3	HUMAN|HGNC=16919|UniProtKB=Q99536	Synaptic vesicle membrane protein VAT-1 homolog	TAS	12932731	PubMed	PTHR44054:SF1	SYNAPTIC VESICLE MEMBRANE PROTEIN VAT-1 HOMOLOG
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	RAT|RGD=619751|UniProtKB=O88302	Guanine nucleotide-binding protein subunit alpha-15	RCA			PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IC	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	IC	91298951	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00053	T cell activation	P01303	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	8051109	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CAEBR|Gene=CBG23090|UniProtKB=A8Y4R0	Protein CBG23090	ISS	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00057	Wnt signaling pathway	P01448	CBP	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	IDA	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00021	FGF signaling pathway	P00632	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01451	Galpha	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00056	VEGF signaling pathway	P01411	Ras	MONDO|Ensembl=ENSMODG00000025248|UniProtKB=F7F5X1	Uncharacterized protein	ISS	3023884	PubMed	PTHR24070:SF186	GTPASE KRAS
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	CANLF|Ensembl=ENSCAFG00000001622|UniProtKB=E2RN76	Uncharacterized protein	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00046	Oxidative stress response	P01130	CHOP	RAT|RGD=62391|UniProtKB=Q62857	DNA damage-inducible transcript 3 protein	TAS	10207617	PubMed	PTHR16833:SF0	DNA DAMAGE-INDUCIBLE TRANSCRIPT 3 PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BOVIN|Ensembl=ENSBTAG00000005714|UniProtKB=Q3ZC07	Actin, alpha cardiac muscle 1	ISS	3487386	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P02771	Pyrimidine Metabolism	P03131	5'-Nucleotidase	MACMU|Ensembl=ENSMMUG00000005442|UniProtKB=F7GPZ7	Uncharacterized protein	RCA	8224905	PubMed	PTHR11575:SF25	5'-NUCLEOTIDASE
P00029	Huntington disease	P00775	Rac	CANLF|Ensembl=ENSCAFG00000015764|UniProtKB=F1PYF1	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF17	RHO-RELATED GTP-BINDING PROTEIN RHOJ
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00010	B cell activation	P00383	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IDA	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00053	T cell activation	P01319	PAK	HUMAN|HGNC=8590|UniProtKB=Q13153	Serine/threonine-protein kinase PAK 1	IDA	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00226	Delta/Serrate	CANLF|Ensembl=ENSCAFG00000005627|UniProtKB=E2QUR0	Delta-like protein	ISS	7697721	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	BOVIN|Ensembl=ENSBTAG00000026580|UniProtKB=F1MB93	Uncharacterized protein	ISS			PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	88241036	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00029	Huntington disease	P00780	Microtubule	PHYPA|Gene=PHYPADRAFT_223215|UniProtKB=Q6TYR8	Beta-tubulin 6	ISS	9454836	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IDA	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MACMU|Ensembl=ENSMMUG00000014807|UniProtKB=F6W548	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00045	Notch signaling pathway	P01099	Notch	MOUSE|MGI=MGI=99460|UniProtKB=Q61982	Neurogenic locus notch homolog protein 3	IC	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00034	Integrin signalling pathway	P00923	Arf1	CANAL|CGD=CAL0003401|UniProtKB=Q5AND9	ADP-ribosylation factor 1	ISS	12932731	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00036	Interleukin signaling pathway	P00967	c-fos	MONDO|Ensembl=ENSMODG00000005927|UniProtKB=F6WX28	Uncharacterized protein	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00056	VEGF signaling pathway	P01407	Erk	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00251	cPLA2	ORNAN|Ensembl=ENSOANG00000001027|UniProtKB=F6QDY0	Phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P02734	Chorismate biosynthesis	P02874	Shikimate kinase	ARATH|TAIR=AT3G26900|UniProtKB=Q9LW20	Probable inactive shikimate kinase like 1, chloroplastic	ISS			PTHR21087:SF4	INACTIVE SHIKIMATE KINASE LIKE 1, CHLOROPLASTIC-RELATED
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	HALSA|EnsemblGenome=VNG_6438G|UniProtKB=Q9HHE9	TATA-box-binding protein F	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00010	B cell activation	P00396	CD45	RAT|RGD=3451|UniProtKB=P04157	Receptor-type tyrosine-protein phosphatase C	IGI	8940015	PubMed	PTHR19134:SF284	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C
P05913	Enkephalin release	P05974	G-Protein (i)	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	IC	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05918	p38 MAPK pathway	P06034	MKK4	MONDO|Ensembl=ENSMODG00000008266|UniProtKB=F6Z879	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00047	PDGF signaling pathway	P01160	IP3 receptor	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	ISS	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00049	Parkinson disease	P01238	14-3-3	PLAF7|EnsemblGenome=MAL8P1.69|UniProtKB=C0H4V6	14-3-3 protein	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P05915	Opioid proenkephalin pathway	P05991	Enkephalin	PANTR|Ensembl=ENSPTRG00000020270|UniProtKB=H2QW70	Proenkephalin	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04393	Ras Pathway	P04558	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01065	VAChT	PANTR|Ensembl=ENSPTRG00000002490|UniProtKB=H2Q1W2	Uncharacterized protein	ISS	21863848	PubMed	PTHR23506:SF13	VESICULAR ACETYLCHOLINE TRANSPORTER
P00053	T cell activation	P01322	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00036	Interleukin signaling pathway	P00987	SRF	HUMAN|HGNC=11291|UniProtKB=P11831	Serum response factor	TAS	15170389	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P04393	Ras Pathway	P04543	MEKK1/4	HUMAN|HGNC=6856|UniProtKB=Q9Y6R4	Mitogen-activated protein kinase kinase kinase 4	IDA	12052864	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	MOUSE|MGI=MGI=106677|UniProtKB=Q8BRU6	Synaptic vesicular amine transporter	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IGI	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00010	B cell activation	P00376	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	HUMAN|HGNC=402|UniProtKB=P00352	Retinal dehydrogenase 1	IC			PTHR11699:SF140	RETINAL DEHYDROGENASE 1
P00047	PDGF signaling pathway	P01165	SRF	BOVIN|Ensembl=ENSBTAG00000012777|UniProtKB=E1BJP4	Uncharacterized protein	ISS	15326221	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00006	Apoptosis signaling pathway	P00260	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05915	Opioid proenkephalin pathway	P05994	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05915	Opioid proenkephalin pathway	P05994	G-protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00056	VEGF signaling pathway	P01408	Akt/PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01427	Naked	DROME|FlyBase=FBgn0002945|UniProtKB=Q9VVV9	Protein naked cuticle	ISS	11356022	PubMed	PTHR22611:SF9	PROTEIN NAKED CUTICLE
P00021	FGF signaling pathway	P00639	Shc	ANOGA|EnsemblGenome=AGAP011463|UniProtKB=Q7Q334	AGAP011463-PA	ISS			PTHR10337:SF11	DSHC PROTEIN
P00057	Wnt signaling pathway	P01472	Histone deacetylase	MACMU|Ensembl=ENSMMUG00000007592|UniProtKB=F6SKL0	Histone deacetylase	ISS	10485845	PubMed	PTHR10625:SF142	HISTONE DEACETYLASE 8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	CAEEL|WormBase=WBGene00001680|UniProtKB=Q20636	Guanine nucleotide-binding protein subunit beta-2	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00029	Huntington disease	P00811	Arp2/3 complex	MONDO|Ensembl=ENSMODG00000007194|UniProtKB=F6X9N6	Actin-related protein 2/3 complex subunit 5	ISS	12932731	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00053	T cell activation	P01306	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	15737619	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TRIAD|EnsemblGenome=TriadG35956|UniProtKB=Q7YTV5	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02742	Tetrahydrofolate biosynthesis	P02945	Dihydropteroate synthase	GLOVI|Gene=BAC88481|UniProtKB=Q7NN73	Dihydropteroate synthase	ISS			PTHR20941:SF1	FOLIC ACID SYNTHESIS PROTEIN FOL1
P00006	Apoptosis signaling pathway	P00274	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CHICK|Ensembl=ENSGALG00000004083|UniProtKB=Q90855	AMPA receptor GluR1/A	ISS	12871085	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00019	Endothelin signaling pathway	P00575	furin	MOUSE|MGI=MGI=97513|UniProtKB=P23188	Furin	ISS	10956649	PubMed	PTHR42884:SF1	FURIN
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02723	Adenine and hypoxanthine salvage pathway	P02812	Deoxyinosine phosphorylase	YEAST|SGD=S000004199|UniProtKB=Q05788	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	RCA	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CHICK|GeneID=431043|UniProtKB=P09652	Tubulin beta-4 chain	ISS	12932731	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00034	Integrin signalling pathway	P00906	Rap1	MACMU|Ensembl=ENSMMUG00000014486|UniProtKB=F7GH95	Ras-related protein Rap-1A	ISS	1904317	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000005917|UniProtKB=F6QM53	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00012	Cadherin signaling pathway	P00474	Wnt	PANTR|Ensembl=ENSPTRG00000009321|UniProtKB=H2QD96	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	RAT|RGD=3273|UniProtKB=P28841	Neuroendocrine convertase 2	IDA			PTHR42884:SF13	NEUROENDOCRINE CONVERTASE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	DANRE|ZFIN=ZDB-GENE-030131-9435|UniProtKB=F1R8S3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00019	Endothelin signaling pathway	P00590	IP3 R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00010	B cell activation	P00371	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	XENTR|Xenbase=XB-GENE-480396|UniProtKB=F7DI28	Protein Wnt (Fragment)	ISS	11266476	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00048	PI3 kinase pathway	P01177	P110ACT	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	ANOGA|EnsemblGenome=AGAP010957|UniProtKB=Q7QGY7	AGAP010957-PA (Fragment)	ISS			PTHR23050:SF245	AT16150P-RELATED
P00010	B cell activation	P00371	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04485	H1	MOUSE|MGI=MGI=107619|UniProtKB=P70174	Histamine H1 receptor	ISS	2670975	PubMed	PTHR43914:SF2	HISTAMINE H1 RECEPTOR
P06587	Nicotine pharmacodynamics pathway	P06595	CHRNA3	RAT|RGD=2345|UniProtKB=P04757	Neuronal acetylcholine receptor subunit alpha-3	ISS	85270494	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P00012	Cadherin signaling pathway	P00470	F-actin	ANOGA|EnsemblGenome=AGAP001676|UniProtKB=Q7PXZ8	AGAP001676-PA	IC	11889126	PubMed	PTHR11937:SF368	ACTIN, INDIRECT FLIGHT MUSCLE
P00053	T cell activation	P01300	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01330	IKK	MACMU|Ensembl=ENSMMUG00000018476|UniProtKB=F6X938	Uncharacterized protein	ISS	9346484	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00046	Oxidative stress response	P01134	cPLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT4G01370|UniProtKB=Q39024	Mitogen-activated protein kinase 4	ISS	10514528	PubMed	PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	HUMAN|HGNC=10935|UniProtKB=Q05940	Synaptic vesicular amine transporter	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01443	Phospholipase C	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IDA	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IDA	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00018	EGF receptor signaling pathway	P00559	MEK1-2	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_188187|UniProtKB=E9GJ31	Guanine nucleotide binding protein, q polypeptide	ISS	9166716	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00053	T cell activation	P01304	Csk	MACMU|Ensembl=ENSMMUG00000015267|UniProtKB=F7GRP2	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P02759	Pyridoxal-5-phosphate biosynthesis	P03058	Phosphohydroxythreonine aminotransferase	ANOGA|EnsemblGenome=AGAP004598|UniProtKB=Q5TRW7	Phosphoserine aminotransferase	ISS			PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	SCHPO|PomBase=SPAC6G9.11|UniProtKB=Q92356	Synaptobrevin homolog 1	ISS	11691998	PubMed	PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P05915	Opioid proenkephalin pathway	P05995	proenkephalin	DANRE|ZFIN=ZDB-GENE-030729-3|UniProtKB=F1QTD1	Uncharacterized protein (Fragment)	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P04392	P53 pathway feedback loops 1	G04685	p73DeltaN	CHICK|Ensembl=ENSGALG00000007324|UniProtKB=F1N8Z7	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00045	Notch signaling pathway	P01119	NIct	BOVIN|Ensembl=ENSBTAG00000043971|UniProtKB=E1BPT8	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00053	T cell activation	P01315	Calcineurin	XENTR|Xenbase=XB-GENE-952299|UniProtKB=B0BLZ8	Serine/threonine-protein phosphatase	ISS	7532676	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00036	Interleukin signaling pathway	P00967	c-fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01455	Smad4	XENTR|Xenbase=XB-GENE-485691|UniProtKB=F7BDU6	Mothers against decapentaplegic homolog (Fragment)	ISS	9395284	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	IDA	96149441	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00018	EGF receptor signaling pathway	P00543	ERK1-2	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02747	Histidine biosynthesis	P02985	Histidinol dehydrogenase	AQUAE|EnsemblGenome=aq_782|UniProtKB=O66976	Histidinol dehydrogenase	ISS			PTHR21256:SF2	HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN
P00018	EGF receptor signaling pathway	P00552	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IGI	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P02743	Formyltetrahydroformate biosynthesis	P02953	Cobalamin dependent homocysteine transmethylase	ARATH|TAIR=AT3G25900|UniProtKB=Q9SDL7	Homocysteine S-methyltransferase 1	ISS			PTHR21091:SF140	HOMOCYSTEINE S-METHYLTRANSFERASE 1
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	LEIMA|EnsemblGenome=LmjF.35.1730|UniProtKB=E9AEZ4	Putative casein kinase II	ISS	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CANAL|CGD=CAL0064759|UniProtKB=Q5AKX0	Uncharacterized protein	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	RAT|RGD=70513|UniProtKB=P30969	Gonadotropin-releasing hormone receptor	IDA			PTHR24241:SF22	GONADOTROPIN-RELEASING HORMONE RECEPTOR
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00005	Angiogenesis	P00189	Fzd	BOVIN|Ensembl=ENSBTAG00000002107|UniProtKB=A7MB15	FZD1 protein	ISS	12549854	PubMed	PTHR11309:SF81	FRIZZLED-1
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CANLF|Ensembl=ENSCAFG00000008637|UniProtKB=F1PGG7	Uncharacterized protein	ISS			PTHR16290:SF4	MRNA-DECAPPING ENZYME 1A
P00029	Huntington disease	P00796	Kainate receptor	RAT|RGD=2733|UniProtKB=P42260	Glutamate receptor ionotropic, kainate 2	IDA	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8692|UniProtKB=Q9Y5E2	Protocadherin beta-7	IDA	8120095	PubMed	PTHR24028:SF69	PROTOCADHERIN BETA-7
P00016	Cytoskeletal regulation by Rho GTPase	P00518	Rho GEFs	HUMAN|HGNC=681|UniProtKB=Q92888	Rho guanine nucleotide exchange factor 1	ISS	12123608	PubMed	PTHR12673:SF122	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=4401|UniProtKB=O14775	Guanine nucleotide-binding protein subunit beta-5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04395	Vasopressin synthesis	P04597	Signal Peptide	PANTR|Ensembl=ENSPTRG00000013189|UniProtKB=H2QJV1	Uncharacterized protein	ISS	192340	OMIM	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00048	PI3 kinase pathway	P01177	P110ACT	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00898	FKHR	PANTR|Ensembl=ENSPTRG00000018476|UniProtKB=H2R710	Forkhead box O3	ISS	15031210	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P02775	Salvage pyrimidine ribonucleotides	P03152	Uridine phosphorylase	MOUSE|MGI=MGI=1097668|UniProtKB=P52624	Uridine phosphorylase 1	ISS			PTHR43691:SF3	URIDINE PHOSPHORYLASE 1
P00045	Notch signaling pathway	P01105	TACE	MOUSE|MGI=MGI=1096335|UniProtKB=Q9Z0F8	Disintegrin and metalloproteinase domain-containing protein 17	ISS	12834808	PubMed	PTHR11905:SF171	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17
P00010	B cell activation	P00391	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00644	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00564	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00036	Interleukin signaling pathway	P00964	p90RSK	MOUSE|MGI=MGI=104557|UniProtKB=P18654	Ribosomal protein S6 kinase alpha-3	IDA	2779569	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P02738	De novo purine biosynthesis	P02901	Adenosuccinate lyase	YEAST|SGD=S000004351|UniProtKB=Q05911	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06777	NFAT	MOUSE|MGI=MGI=1920431|UniProtKB=Q8K120	Nuclear factor of activated T-cells, cytoplasmic 4	RCA	12015605	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00018	EGF receptor signaling pathway	P00547	PP2A	MACMU|Ensembl=ENSMMUG00000008205|UniProtKB=F7GWP9	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	ISS	11007767	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00058	mRNA splicing	P01473	U6	BOVIN|Gene=PRPF3|UniProtKB=Q2KIA6	U4/U6 small nuclear ribonucleoprotein Prp3	ISS	12875835	PubMed	PTHR14212:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00049	Parkinson disease	P01227	20S proteasome	DROME|FlyBase=FBgn0265606|UniProtKB=Q24178	Proteasome subunit alpha type-7-1A	TAS	12859888	PubMed	PTHR11599:SF15	PROTEASOME SUBUNIT ALPHA TYPE
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P06664	Gonadotropin-releasing hormone receptor pathway	P06768	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	RCA	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02731	Biotin biosynthesis	P02857	Biotin synthase	AQUAE|EnsemblGenome=aq_975|UniProtKB=O67104	Biotin synthase	ISS			PTHR22976:SF1	BIOTIN SYNTHASE, MITOCHONDRIAL
P02734	Chorismate biosynthesis	P02870	3-Phosphoshikimate-1-carboxyvinyl transferase	GLOVI|EnsemblGenome=BAC88979|UniProtKB=Q7NLT3	3-phosphoshikimate 1-carboxyvinyltransferase	ISS			PTHR21090:SF5	PENTAFUNCTIONAL AROM POLYPEPTIDE
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DROME|FlyBase=FBgn0030011|UniProtKB=Q9W3J1	Gbeta5	IC	9754712	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	TAS	12846562	PubMed	PTHR10202:SF13	PRESENILIN-2
P00052	TGF-beta signaling pathway	P01286	TGFbeta	CANLF|Ensembl=ENSCAFG00000009587|UniProtKB=E2RJJ6	Metalloendopeptidase	ISS	9759503	PubMed	PTHR43978:SF3	BONE MORPHOGENETIC PROTEIN 1
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IDA	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00049	Parkinson disease	P01212	p38 MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00059	p53 pathway	P01486	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	1170702	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04387	Histamine synthesis	P04493	Histidine decarboxylase	MACMU|Ensembl=ENSMMUG00000002877|UniProtKB=F7HFR2	Histidine decarboxylase	ISS	1702422	PubMed	PTHR11999:SF68	HISTIDINE DECARBOXYLASE
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04393	Ras Pathway	P04547	Ras	XENTR|Xenbase=XB-GENE-494548|UniProtKB=F7EC26	Uncharacterized protein	ISS	20362513	PubMed	PTHR24070:SF186	GTPASE KRAS
P00018	EGF receptor signaling pathway	P00559	MEK1-2	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00059	p53 pathway	P04609	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00052	TGF-beta signaling pathway	P01275	P38	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	TAS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00025	Hedgehog signaling pathway	P00692	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	PANTR|Gene=DRD2|UniProtKB=P60026	D(2) dopamine receptor	ISS	11861492	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00570	PKA	PLAF7|EnsemblGenome=PFL1110c|UniProtKB=Q7KQK0	CAMP-dependent protein kinase regulatory subunit, putative	ISS	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04384	Gamma-aminobutyric acid synthesis	P04480	GABA aminotransferase	HUMAN|HGNC=23|UniProtKB=P80404	4-aminobutyrate aminotransferase, mitochondrial	RCA			PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00053	T cell activation	P01311	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	MYCTU|EnsemblGenome=Rv2445c|UniProtKB=P9WJH7	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MONDO|Ensembl=ENSMODG00000004422|UniProtKB=F6SCX2	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF344	MYOSIN-7
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	BOVIN|Ensembl=ENSBTAG00000005903|UniProtKB=F1N1K8	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00057	Wnt signaling pathway	P01431	LRP5/6	CHICK|Ensembl=ENSGALG00000011558|UniProtKB=F1NWV6	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00025	Hedgehog signaling pathway	P00682	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CAEEL|WormBase=WBGene00004036|UniProtKB=G5EFI8	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ARATH|TAIR=AT5G09810|UniProtKB=P53492	Actin-7	IDA			PTHR11937:SF155	ACTIN-5C-RELATED
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	TAS	10395542	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00019	Endothelin signaling pathway	P00586	Gq	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	TAS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00034	Integrin signalling pathway	P00949	Shc	DROME|FlyBase=FBgn0015296|UniProtKB=Q9V3C8	DShc protein	IPI	8491186	PubMed	PTHR10337:SF11	DSHC PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00012	Cadherin signaling pathway	P00462	Casein kinase II	DANRE|ZFIN=ZDB-GENE-040625-181|UniProtKB=Q6IQV0	Uncharacterized protein	ISS	10617630	PubMed	PTHR24054:SF28	CASEIN KINASE 2 ALPHA 1
P00054	Toll receptor signaling pathway	P01356	ERK2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00029	Huntington disease	P00790	beta-Tubulin	XENTR|Xenbase=XB-GENE-491121|UniProtKB=Q6P367	Tubulin, beta 2B	ISS	9454836	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00572	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00060	Ubiquitin proteasome pathway	P01490	E3	CANLF|Ensembl=ENSCAFG00000015133|UniProtKB=F1PQT6	Uncharacterized protein	ISS	11252892	PubMed	PTHR11254:SF293	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P00005	Angiogenesis	P00194	Paxillin	DROME|FlyBase=FBgn0051988|UniProtKB=Q8T0V8	GH01042p	ISS			PTHR24216:SF46	GH01042P-RELATED
P00053	T cell activation	P01300	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DICPU|Gene=DICPUDRAFT_92985|UniProtKB=F1A084	Putative uncharacterized protein rac1A	ISS	4757952	gi	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05964	GNAZ	MACMU|Ensembl=ENSMMUG00000001776|UniProtKB=F7GJC8	Guanine nucleotide-binding protein G(Z) subunit alpha	ISS	16814816	PubMed	PTHR10218:SF65	GUANINE NUCLEOTIDE-BINDING PROTEIN G Z  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01152	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	8270251	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	DROME|Gene=Dmel_CG1891|UniProtKB=A0A0B4K7J3	Receptor protein serine/threonine kinase	TAS	9395284	PubMed	PTHR23255:SF72	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ORYSJ|EnsemblGenome=OS05G0106600|UniProtKB=Q65XH8	Os05g0106600 protein	IDA	14684598	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P04395	Vasopressin synthesis	P04589	Signal Peptidase	MACMU|Ensembl=ENSMMUG00000023608|UniProtKB=F7HD92	Uncharacterized protein	ISS	2092035	PubMed	PTHR13085:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	TAS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	MACMU|Ensembl=ENSMMUG00000003370|UniProtKB=F7E8G2	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00059	p53 pathway	P04623	CBP	ARATH|TAIR=AT1G79000|UniProtKB=Q9C5X9	Histone acetyltransferase HAC1	ISS	8413673	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	MOUSE|MGI=MGI=1351660|UniProtKB=Q9JMK2	Casein kinase I isoform epsilon	ISS	11865049	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00030	Hypoxia response via HIF activation	P00823	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00591	PLCbeta	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01065	VAChT	HUMAN|HGNC=10936|UniProtKB=Q16572	Vesicular acetylcholine transporter	IC			PTHR23506:SF13	VESICULAR ACETYLCHOLINE TRANSPORTER
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00029	Huntington disease	P00807	Actin	CANLF|Ensembl=ENSCAFG00000015708|UniProtKB=F2Z4N0	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00018	EGF receptor signaling pathway	P00557	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IGI	10799299	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00029	Huntington disease	P00807	Actin	RAT|RGD=628837|UniProtKB=P60711	Actin, cytoplasmic 1	IDA	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00055	Transcription regulation by bZIP transcription factor	P01389	TTF2	HUMAN|HGNC=12397|UniProtKB=Q15361	Transcription termination factor 1	IGI			PTHR10641:SF939	TRANSCRIPTION TERMINATION FACTOR 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PANTR|Ensembl=ENSPTRG00000005118|UniProtKB=H2Q6A1	Uncharacterized protein	ISS			PTHR13140:SF291	UNCONVENTIONAL MYOSIN-IA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00005	Angiogenesis	P00206	Wnt	BOVIN|Ensembl=ENSBTAG00000008097|UniProtKB=A4D7S0	Protein Wnt-2	ISS	8717036	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00059	p53 pathway	P04633	P110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02770	Pyridoxal phosphate salvage pathway	P03123	Pyridoxine-5-phosphate oxidase	SCHPO|PomBase=SPAC1093.02|UniProtKB=Q9UTQ1	Probable pyridoxamine 5'-phosphate oxidase	ISS	11859360	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P04373	5HT1 type receptor mediated signaling pathway	P04407	K+ channel	RAT|RGD=61997|UniProtKB=O54912	Potassium channel subfamily K member 3	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04657	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00641	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00021	FGF signaling pathway	P00633	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00036	Interleukin signaling pathway	P00977	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02753	Methionine biosynthesis	P03024	Homocysteine transmethylase	ECOLI|EcoGene=EG10587|UniProtKB=P13009	Methionine synthase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00029	Huntington disease	P00799	JNK-2	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	CHICK|Ensembl=ENSGALG00000003820|UniProtKB=E1C8Y3	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	MOUSE|MGI=MGI=88276|UniProtKB=Q02248	Catenin beta-1	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00006	Apoptosis signaling pathway	P00302	ATF	PANTR|Ensembl=ENSPTRG00000012660|UniProtKB=H2QJ07	Activating transcription factor 2	ISS	11390664	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00005	Angiogenesis	P00224	PDGF	DANRE|ZFIN=ZDB-GENE-030918-2|UniProtKB=A5PMP7	Uncharacterized protein	ISS			PTHR11633:SF3	PLATELET-DERIVED GROWTH FACTOR SUBUNIT A
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00047	PDGF signaling pathway	P01160	IP3 receptor	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	8170357	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00045	Notch signaling pathway	G01541	E(spl)-C genes	HUMAN|HGNC=4881|UniProtKB=Q9UBP5	Hairy/enhancer-of-split related with YRPW motif protein 2	ISS			PTHR10985:SF88	HAIRY/ENHANCER-OF-SPLIT RELATED WITH YRPW MOTIF PROTEIN 2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00018	EGF receptor signaling pathway	P00545	JNK1-3	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2520|UniProtKB=P61169	D(2) dopamine receptor	IDA	2039532	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00001	Adrenaline and noradrenaline biosynthesis	P00064	NET	RAT|RGD=621822|UniProtKB=F1LNR9	Transporter	ISS	97248649	PubMed	PTHR11616:SF37	SODIUM-DEPENDENT NORADRENALINE TRANSPORTER
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04407	K+ channel	BOVIN|Ensembl=ENSBTAG00000018193|UniProtKB=E1BHX8	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00054	Toll receptor signaling pathway	P01369	MKK1	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	STRPU|EnsemblGenome=SPU_019233|UniProtKB=W4YTT9	Uncharacterized protein	ISS	9727008	PubMed	PTHR10410:SF5	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 14
P05915	Opioid proenkephalin pathway	P05994	G-protein	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00010	B cell activation	P00398	IP3R	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	IGI	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	94280860	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00029	Huntington disease	P00786	ARF	CAEEL|WormBase=WBGene00000192|UniProtKB=G5EDC6	ARF-Like	IPI	12932731	PubMed	PTHR11711:SF20	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	MACMU|Ensembl=ENSMMUG00000018506|UniProtKB=F6TTC6	Folylpolyglutamate synthase	ISS			PTHR11136:SF5	FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ARATH|TAIR=AT2G42880|UniProtKB=Q9SJG9	Mitogen-activated protein kinase 20	IDA	10851062	PubMed	PTHR24055:SF158	MITOGEN-ACTIVATED PROTEIN KINASE 20
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	IC	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05918	p38 MAPK pathway	P06042	4E-BP1	RAT|RGD=620259|UniProtKB=Q62622	Eukaryotic translation initiation factor 4E-binding protein 1	RCA	15494402	PubMed	PTHR12669:SF14	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1
P00046	Oxidative stress response	P01136	Elk-1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	TAS	3183861	gi	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	3045562	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00005	Angiogenesis	P00219	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IDA	10644715	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00012	Cadherin signaling pathway	P00475	Frizzled	BOVIN|Ensembl=ENSBTAG00000002107|UniProtKB=A7MB15	FZD1 protein	ISS	8717036	PubMed	PTHR11309:SF81	FRIZZLED-1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	TAS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	IDA	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00009	Axon guidance mediated by netrin	P00359	NFAT	CANLF|Ensembl=ENSCAFG00000011625|UniProtKB=F1PDD9	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00018	EGF receptor signaling pathway	P00565	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00045	Notch signaling pathway	P01107	Fringe	MOUSE|MGI=MGI=1095404|UniProtKB=O09008	Beta-1,3-N-acetylglucosaminyltransferase manic fringe	IGI	9187150	PubMed	PTHR10811:SF6	BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE MANIC FRINGE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00056	VEGF signaling pathway	P01408	Akt/PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	TAKRU|Ensembl=ENSTRUG00000011297|UniProtKB=H2TV18	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	MOUSE|MGI=MGI=97364|UniProtKB=O35516	Neurogenic locus notch homolog protein 2	IDA	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00034	Integrin signalling pathway	P00927	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF31	SUBFAMILY NOT NAMED
P00014	Cholesterol biosynthesis	P00496	Diphosphomevalonate decarboxylase	ARATH|TAIR=AT2G38700|UniProtKB=O23722	Diphosphomevalonate decarboxylase MVD1	ISS	4505289	gi	PTHR10977:SF3	DIPHOSPHOMEVALONATE DECARBOXYLASE
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00011	Blood coagulation	P00410	GP IIb	CANLF|Ensembl=ENSCAFG00000014145|UniProtKB=F1PRU9	Uncharacterized protein	ISS	5733734	gi	PTHR23220:SF73	INTEGRIN ALPHA-IIB
P05912	Dopamine receptor mediated signaling pathway	P05957	K+ channel	HUMAN|HGNC=6283|UniProtKB=Q9NPC2	Potassium channel subfamily K member 9	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	CAEBR|Gene=CBG_05938|UniProtKB=H8WGV2	Protein CBR-ITR-1, isoform a	ISS	9065779	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00030	Hypoxia response via HIF activation	P00819	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01295	vav	MOUSE|MGI=MGI=98923|UniProtKB=P27870	Proto-oncogene vav	IDA	14623913	PubMed	PTHR22826:SF112	PROTO-ONCOGENE VAV
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	CANLF|Ensembl=ENSCAFG00000013324|UniProtKB=F1PCS0	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00054	Toll receptor signaling pathway	G01550	Gene trancription	MOUSE|MGI=MGI=107936|UniProtKB=P70380	Interleukin-18	ISS	11710997	PubMed	PTHR45200:SF1	INTERLEUKIN-18
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	MONDO|Ensembl=ENSMODG00000018204|UniProtKB=F6PGX6	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00037	Ionotropic glutamate receptor pathway	P01026	KA	BOVIN|Ensembl=ENSBTAG00000011723|UniProtKB=E1BKL6	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	TAS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	MACMU|Ensembl=ENSMMUG00000005008|UniProtKB=F6VJI3	Cyclic AMP-responsive element-binding protein 3-like protein 4	ISS	608972	OMIM	PTHR22952:SF105	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04586	ProTRH (Pro Thyrotropin-releasing Hormone)	CHICK|Ensembl=ENSGALG00000002550|UniProtKB=O57340	Thyrotropin subunit beta	ISS			PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P00005	Angiogenesis	P00249	PAK	MOUSE|MGI=MGI=1339984|UniProtKB=Q8CIN4	Serine/threonine-protein kinase PAK 2	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	PANTR|Ensembl=ENSPTRG00000023608|UniProtKB=H2QZZ2	Uncharacterized protein	ISS	11554549	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	TAS	98269030	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00051	TCA cycle	P01270	Malate Dehydrogenase	LEPIN|EnsemblGenome=LA_2139|UniProtKB=Q8F4A2	Malate dehydrogenase	IEA	12712204	PubMed	PTHR23382:SF0	MALATE DEHYDROGENASE 2, MITOCHONDRIAL-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00234	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8316835	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00056	VEGF signaling pathway	P01418	Paxillin	RAT|RGD=1305759|UniProtKB=Q66H76	Paxillin	ISS	7579684	PubMed	PTHR24216:SF11	PAXILLIN
P00052	TGF-beta signaling pathway	P01275	P38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00007	Axon guidance mediated by semaphorins	P00330	CRAM	HUMAN|HGNC=20637|UniProtKB=Q9BPU6	Dihydropyrimidinase-related protein 5	IEP	11034345	PubMed	PTHR11647:SF58	DIHYDROPYRIMIDINASE-RELATED PROTEIN 5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IDA	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00029	Huntington disease	P00799	JNK-2	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	ARATH|TAIR=AT3G52930|UniProtKB=Q9LF98	Fructose-bisphosphate aldolase	TAS	15227981	gi	PTHR11627:SF24	FRUCTOSE-BISPHOSPHATE ALDOLASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00009	Axon guidance mediated by netrin	P00366	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P02781	Threonine biosynthesis	P03189	Aspartate kinase	THEMA|EnsemblGenome=TM_1518|UniProtKB=Q9X1K6	Aspartokinase	ISS			PTHR21499:SF3	ASPARTOKINASE
P06587	Nicotine pharmacodynamics pathway	P06614	TH	HUMAN|HGNC=11782|UniProtKB=P07101	Tyrosine 3-monooxygenase	RCA	12814656	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00048	PI3 kinase pathway	P01181	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00056	VEGF signaling pathway	P01417	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00187	beta catenin	RAT|RGD=70487|UniProtKB=Q9WU82	Catenin beta-1	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IGI	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05925	beta-ARR1	PANTR|Ensembl=ENSPTRG00000004079|UniProtKB=H2R1Z2	Uncharacterized protein	ISS	9388255	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P05918	p38 MAPK pathway	P06029	p38beta	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00029	Huntington disease	P00766	Htt	MOUSE|MGI=MGI=96067|UniProtKB=P42859	Huntingtin	IDA	9462744	PubMed	PTHR10170:SF10	HUNTINGTIN
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	HUMAN|HGNC=20773|UniProtKB=Q3ZCM7	Tubulin beta-8 chain	ISS	12932731	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00052	TGF-beta signaling pathway	P01284	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	IDA	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00907	ERK	RAT|RGD=62087|UniProtKB=P27704	Mitogen-activated protein kinase 6	ISS	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00034	Integrin signalling pathway	P00951	Jnk	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P06664	Gonadotropin-releasing hormone receptor pathway	P06849	Sos	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	RCA	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	IDA	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00021	FGF signaling pathway	P00629	PP2A	CAEEL|WormBase=WBGene00004086|UniProtKB=Q9XTT8	Serine/threonine-protein phosphatase 4 catalytic subunit 2	ISS			PTHR11668:SF22	SERINE/THREONINE-PROTEIN PHOSPHATASE 4 CATALYTIC SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00586	Gq	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P06587	Nicotine pharmacodynamics pathway	P06610	CHRNB4	BOVIN|Gene=CHRNB4|UniProtKB=Q8SPU6	Neuronal acetylcholine receptor subunit beta-4	IDA	11602335	PubMed	PTHR18945:SF385	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-4
P00059	p53 pathway	G04696	Siah	PANTR|Ensembl=ENSPTRG00000008094|UniProtKB=H2QB23	E3 ubiquitin-protein ligase	ISS	14985507	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00021	FGF signaling pathway	P00627	ERK1-2	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	NAS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01185	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	DEIRA|EnsemblGenome=DR_1878|UniProtKB=Q9RT87	Inosine-5'-monophosphate dehydrogenase	ISS			PTHR11911:SF6	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	PANTR|Ensembl=ENSPTRG00000007711|UniProtKB=H2QAH4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF319	ADENYLATE CYCLASE TYPE 9
P00021	FGF signaling pathway	P00648	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04398	p53 pathway feedback loops 2	P04651	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P02777	Succinate to proprionate conversion	P03163	Methylmalonyl-CoA decarboxylase	STRCO|Gene=CAC37885|UniProtKB=Q93S05	Putative decarboxylase	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P00005	Angiogenesis	P00183	Shc	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	IDA	7680960	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00012	Cadherin signaling pathway	P00474	Wnt	MONDO|Ensembl=ENSMODG00000012401|UniProtKB=F6PMQ6	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00005	Angiogenesis	P00187	beta catenin	BOVIN|Ensembl=ENSBTAG00000016420|UniProtKB=Q0VCX4	Catenin beta-1	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MONDO|Ensembl=ENSMODG00000001775|UniProtKB=F6WJB1	Uncharacterized protein	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00048	PI3 kinase pathway	P01190	PDK1 ACT	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	IDA	15210700	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00021	FGF signaling pathway	P00640	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00038	JAK/STAT signaling pathway	P01027	STAT	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02787	Vitamin B6 metabolism	P03242	Threonine synthase	SULSO|EnsemblGenome=SSO0878|UniProtKB=Q97ZL6	Threonine synthase	ISS	11427726	PubMed	PTHR10314:SF5	THREONINE SYNTHASE 1, CHLOROPLASTIC
P00005	Angiogenesis	P00226	Delta/Serrate	MACMU|Ensembl=ENSMMUG00000018116|UniProtKB=F7FGM9	Delta-like protein	ISS	8955070	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00021	FGF signaling pathway	P00628	JNK1-3	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06812	L-type Ca2+	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	RCA	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	STRPU|EnsemblGenome=SPU_000062|UniProtKB=W4X9L8	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00017	DNA replication	P00527	Histones	MACMU|Ensembl=ENSMMUG00000031506|UniProtKB=F7GHH9	Histone H3	ISS	12413958	PubMed	PTHR11426:SF184	HISTONE H3.1T
P00053	T cell activation	P01318	PKC-theta	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00057	Wnt signaling pathway	P01446	Calcineurin	HUMAN|HGNC=9315|UniProtKB=P16298	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	IDA	12015605	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	YEAST|SGD=S000005854|UniProtKB=P33328	Synaptobrevin homolog 2	IC			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00047	PDGF signaling pathway	P01160	IP3 receptor	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	BOVIN|Gene=CHRNB4|UniProtKB=Q8SPU6	Neuronal acetylcholine receptor subunit beta-4	IC	11602335	PubMed	PTHR18945:SF385	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04580	TRH Receptor	PANTR|Ensembl=ENSPTRG00000020508|UniProtKB=H2R9Q8	Uncharacterized protein	ISS	14599121	PubMed	PTHR24243:SF115	THYROTROPIN-RELEASING HORMONE RECEPTOR
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CANLF|Ensembl=ENSCAFG00000016020|UniProtKB=O18840	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00046	Oxidative stress response	P01134	cPLA2	BOVIN|Ensembl=ENSBTAG00000013298|UniProtKB=A4IFJ5	Cytosolic phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00045	Notch signaling pathway	P01119	NIct	RAT|RGD=3188|UniProtKB=Q9QW30	Neurogenic locus notch homolog protein 2	IEP	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P05913	Enkephalin release	P05974	G-Protein (i)	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00546	GAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00010	B cell activation	P00394	BLNK	PANTR|Ensembl=ENSPTRG00000002792|UniProtKB=H2Q2B8	Uncharacterized protein	ISS	11274146	PubMed	PTHR14098:SF3	B-CELL LINKER PROTEIN
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	TAS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00019	Endothelin signaling pathway	P00570	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	HUMAN|HGNC=1442|UniProtKB=P62158	Calmodulin	IDA			PTHR23050:SF311	CALMODULIN
P00021	FGF signaling pathway	P00624	14-3-3	DANRE|ZFIN=ZDB-GENE-030131-779|UniProtKB=Q7ZW20	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	RCA	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00046	Oxidative stress response	P01129	JNK1/2	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	TAKRU|Ensembl=ENSTRUG00000001556|UniProtKB=H2RTU5	Uncharacterized protein (Fragment)	IDA			PTHR43893:SF11	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00564	Rac	ORYSJ|EnsemblGenome=OS02G0742200|UniProtKB=Q6Z808	Rac-like GTP-binding protein 3	ISS			PTHR24072:SF149	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=1310389|UniProtKB=D3ZTF6	Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Predicted), isoform CRA_a	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	MACMU|Ensembl=ENSMMUG00000019999|UniProtKB=F7FNE2	Uncharacterized protein	ISS	11443533	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P05731	GABA-B receptor II signaling	P05754	Ggamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00049	Parkinson disease	P01242	Casein kinase I	LEIMA|EnsemblGenome=LmjF.35.1010|UniProtKB=Q9NHE1	Casein kinase 1 isoform 2	IDA	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00029	Huntington disease	P00788	Calpain	BOVIN|Gene=CAPN3|UniProtKB=P51186	Calpain-3	IDA	11675509	PubMed	PTHR10183:SF329	CALPAIN-3
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	TAS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MACMU|Ensembl=ENSMMUG00000009341|UniProtKB=F6UA54	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00036	Interleukin signaling pathway	P00965	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CHICK|Ensembl=ENSGALG00000014235|UniProtKB=Q3L254	Protein Wnt-7b	ISS	8717036	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	HUMAN|HGNC=1960|UniProtKB=P36544	Neuronal acetylcholine receptor subunit alpha-7	ISS	85270494	PubMed	PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P00037	Ionotropic glutamate receptor pathway	P01020	NSF	BOVIN|Ensembl=ENSBTAG00000008442|UniProtKB=F1MZU2	Uncharacterized protein	ISS	601633	OMIM	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	PANTR|Gene=CHRM5|UniProtKB=Q5IS53	Muscarinic acetylcholine receptor M5	ISS	11166329	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00034	Integrin signalling pathway	P00910	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	8479536	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P02751	Lysine biosynthesis	P03011	N-succinyldiaminopimelate  aminotransferase	PYRAE|EnsemblGenome=PAE2515|UniProtKB=Q8ZV07	Acetylornithine/acetyl-lysine aminotransferase	IDA			PTHR11986:SF79	ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00034	Integrin signalling pathway	P00928	alpha actinin	MACMU|Ensembl=ENSMMUG00000002494|UniProtKB=F7HER2	Uncharacterized protein	ISS	2116421	PubMed	PTHR43947:SF6	ALPHA-ACTININ-3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05731	GABA-B receptor II signaling	P05754	Ggamma	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00029	Huntington disease	P00796	Kainate receptor	RAT|RGD=2732|UniProtKB=P22756	Glutamate receptor ionotropic, kainate 1	IDA	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00865	Shc	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	ISS	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=12787|UniProtKB=P56706	Protein Wnt-7b	IDA	8717036	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CHICK|Ensembl=ENSGALG00000001172|UniProtKB=P19439	Probable glutamate receptor	ISS	12871085	PubMed	PTHR18966:SF282	GLUTAMATE RECEPTOR-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00029	Huntington disease	P00786	ARF	TAKRU|Ensembl=ENSTRUG00000007465|UniProtKB=H2T1E8	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF291	ADP-RIBOSYLATION FACTOR 1
P00021	FGF signaling pathway	P00644	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	LEIMA|EnsemblGenome=LmjF.35.3960|UniProtKB=E9AFM1	Protein kinase A catalytic subunit isoform 2	IC	14744463	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00023	General transcription regulation	P00662	TFIIA complex	MACMU|Ensembl=ENSMMUG00000022122|UniProtKB=F7H5J8	Transcription initiation factor IIA subunit 1 isoform 1	ISS	600519	OMIM	PTHR12694:SF7	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1
P00012	Cadherin signaling pathway	P00470	F-actin	DROME|FlyBase=FBgn0000046|UniProtKB=P10981	Actin-87E	IC	11889126	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	HUMAN|HGNC=129|UniProtKB=P68133	Actin, alpha skeletal muscle	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00029	Huntington disease	P00786	ARF	PLAF7|EnsemblGenome=PF10_0337|UniProtKB=Q8IJ63	ADP-ribosylation factor, putative	IPI	12932731	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	HUMAN|HGNC=405|UniProtKB=P30838	Aldehyde dehydrogenase, dimeric NADP-preferring	IC	14724059	PubMed	PTHR43570:SF15	ALDEHYDE DEHYDROGENASE, DIMERIC NADP-PREFERRING
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	HUMAN|HGNC=10436|UniProtKB=P23443	Ribosomal protein S6 kinase beta-1	ISS	15116068	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P05918	p38 MAPK pathway	P06016	HSP27	CHICK|Gene=HSPB1|UniProtKB=Q00649	Heat shock protein beta-1	RCA			PTHR11527:SF114	HEAT SHOCK PROTEIN BETA-1
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	IDA	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00010	B cell activation	P00383	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	TAS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00547	PP2A	BOVIN|Ensembl=ENSBTAG00000005533|UniProtKB=F1N1S8	Uncharacterized protein	ISS	12110603	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00057	Wnt signaling pathway	P01451	Galpha	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	IDA	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00048	PI3 kinase pathway	P01185	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00050	Plasminogen activating cascade	P01246	Plasmin	HUMAN|HGNC=9071|UniProtKB=P00747	Plasminogen	ISS	2318848	PubMed	PTHR24261:SF6	PLASMINOGEN
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00057	Wnt signaling pathway	P01465	Ggamma	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00055	Transcription regulation by bZIP transcription factor	P01395	TFIIE	YEAST|SGD=S000001770|UniProtKB=P36145	Transcription initiation factor IIE subunit beta	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TRIAD|EnsemblGenome=TriadG35956|UniProtKB=Q7YTV5	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00029	Huntington disease	P00775	Rac	PANTR|Ensembl=ENSPTRG00000028742|UniProtKB=H2R5M6	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF158	RHO-RELATED GTP-BINDING PROTEIN RHOG
P00060	Ubiquitin proteasome pathway	P01491	E2	XENTR|Xenbase=XB-GENE-1015103|UniProtKB=Q28G19	Ubiquitin-conjugating enzyme E2 variant 1	ISS			PTHR43915:SF3	UBIQUITIN-CONJUGATING ENZYME E2 VARIANT 2
P00047	PDGF signaling pathway	P01153	GSK3	ARATH|TAIR=AT3G61160|UniProtKB=O23145	Shaggy-related protein kinase beta	ISS	7529201	PubMed	PTHR24057:SF19	SHAGGY-RELATED PROTEIN KINASE BETA-RELATED
P00011	Blood coagulation	P00418	Fibrin monomer	BOVIN|Gene=FGG|UniProtKB=P12799	Fibrinogen gamma-B chain	ISS	89366676	PubMed	PTHR19143:SF338	FIBRINOGEN GAMMA CHAIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P02787	Vitamin B6 metabolism	P03236	Pyridoxamine phosphate oxidase	MACMU|Ensembl=ENSMMUG00000003325|UniProtKB=F7EHD9	Pyridoxine-5'-phosphate oxidase	ISS	9601034	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00589	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00010	B cell activation	P00369	MEKK	MOUSE|MGI=MGI=1346873|UniProtKB=Q61083	Mitogen-activated protein kinase kinase kinase 2	IDA	8649450	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00038	JAK/STAT signaling pathway	P01027	STAT	DANRE|ZFIN=ZDB-GENE-980526-499|UniProtKB=Q6P943	Signal transducer and activator of transcription	ISS	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00034	Integrin signalling pathway	P00939	Fibronectin	DANRE|ZFIN=ZDB-GENE-000426-1|UniProtKB=B0S602	Uncharacterized protein	IDA	12970173	PubMed	PTHR19143:SF267	FIBRONECTIN
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	LEIMA|EnsemblGenome=LmjF.35.4010|UniProtKB=Q9GNR4	Protein kinase A catalytic subunit isoform 1	IC	14744463	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	G01543	IGFBP1	HUMAN|HGNC=5469|UniProtKB=P08833	Insulin-like growth factor-binding protein 1	IDA	12493691	PubMed	PTHR11551:SF6	INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00056	VEGF signaling pathway	P01407	Erk	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	227170	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	CAEBR|Gene=CBG02401|UniProtKB=A8WUE7	Protein CBR-NMR-1	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	P04633	P110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MACMU|Ensembl=ENSMMUG00000000180|UniProtKB=F7HJM7	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00748	Gbeta5L	XENTR|Xenbase=XB-GENE-977853|UniProtKB=F7EBE7	Uncharacterized protein	ISS	10051575	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00005	Angiogenesis	P00256	PLC-gamma	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00048	PI3 kinase pathway	P01179	PKB	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	TAS	9716402	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	DANRE|ZFIN=ZDB-GENE-040426-877|UniProtKB=F1Q6Z7	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00628	JNK1-3	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PRIPA|Gene=PPA21758|UniProtKB=H3FHL1	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF89	TUBULIN BETA-4 CHAIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	PANTR|Ensembl=ENSPTRG00000020210|UniProtKB=Q5IS76	Neuronal acetylcholine receptor subunit alpha-6	ISS	85270494	PubMed	PTHR18945:SF82	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-6
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	MONDO|Ensembl=ENSMODG00000001807|UniProtKB=F6Y7R9	Uncharacterized protein	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00060	Ubiquitin proteasome pathway	P01491	E2	PANTR|Ensembl=ENSPTRG00000005754|UniProtKB=H2Q7D5	Uncharacterized protein	ISS	10888878	PubMed	PTHR24068:SF67	UBIQUITIN-CONJUGATING ENZYME E2 L3
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	RCA	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05915	Opioid proenkephalin pathway	P05988	peptide E	BOVIN|Ensembl=ENSBTAG00000004924|UniProtKB=P01211	Proenkephalin-A	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P02738	De novo purine biosynthesis	P02909	GDP reductase	PSEAE|EnsemblGenome=PA5497|UniProtKB=Q9HT76	NrdJa	ISS			PTHR43371:SF1	SUBFAMILY NOT NAMED
P00010	B cell activation	P00391	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00010	B cell activation	P00383	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00036	Interleukin signaling pathway	P00965	ERK	RAT|RGD=628675|UniProtKB=Q9Z2A6	Mitogen-activated protein kinase 15	TAS	12787066	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P04393	Ras Pathway	P04542	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00046	Oxidative stress response	P01137	MNK1/2	RAT|RGD=1559603|UniProtKB=Q4G050	MAP kinase-interacting serine/threonine-protein kinase 1	ISS	9155017	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01142	p90RSK	PANTR|Ensembl=ENSPTRG00000022064|UniProtKB=H2QYE0	Uncharacterized protein	ISS	15632195	PubMed	PTHR24351:SF98	RIBOSOMAL PROTEIN S6 KINASE ALPHA-6
P00034	Integrin signalling pathway	P00916	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IPI	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	P01443	Phospholipase C	CAEEL|WormBase=WBGene00004037|UniProtKB=Q9XWB7	Phosphoinositide phospholipase C	IDA	10934033	PubMed	PTHR10336:SF9	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00006	Apoptosis signaling pathway	P00260	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00589	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00011	Blood coagulation	P00419	FXIIIa	CHICK|Ensembl=ENSGALG00000012802|UniProtKB=E1BWG1	Uncharacterized protein	ISS	10636369	gi	PTHR11590:SF42	COAGULATION FACTOR XIII A CHAIN
P00034	Integrin signalling pathway	P00917	ELMO	MACMU|Ensembl=ENSMMUG00000015064|UniProtKB=F6WWC5	Engulfment and cell motility protein 2	ISS	12879077	PubMed	PTHR12771:SF8	ENGULFMENT AND CELL MOTILITY PROTEIN 2
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	RAT|RGD=2155|UniProtKB=O88656	Actin-related protein 2/3 complex subunit 1B	ISS	9618202	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00034	Integrin signalling pathway	P00927	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	4757952	gi	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00010	B cell activation	P00371	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9836512	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	XENTR|Xenbase=XB-GENE-490756|UniProtKB=F7BXC9	Uncharacterized protein (Fragment)	ISS	9043084	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00048	PI3 kinase pathway	P01199	Galpha	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IC	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00559	MEK1-2	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2847|UniProtKB=P28565	5-hydroxytryptamine receptor 1D	IDA	11701344	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00047	PDGF signaling pathway	P01142	p90RSK	CANLF|Ensembl=ENSCAFG00000011590|UniProtKB=E2R7K9	Ribosomal protein S6 kinase	ISS	15116068	PubMed	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00018	EGF receptor signaling pathway	P00561	STAT	MOUSE|MGI=MGI=103036|UniProtKB=P42230	Signal transducer and activator of transcription 5A	IGI	14662325	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00057	Wnt signaling pathway	P01471	alpha-catenin	DROME|FlyBase=FBgn0010215|UniProtKB=P35220	Catenin alpha	IDA	9362521	PubMed	PTHR18914:SF9	CATENIN ALPHA
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P02751	Lysine biosynthesis	P03007	Diaminopimelate decarboxylase	BACSU|EnsemblGenome=BSU23380|UniProtKB=P23630	Diaminopimelate decarboxylase	ISS			PTHR43727:SF2	DIAMINOPIMELATE DECARBOXYLASE 1, CHLOROPLASTIC-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	CHICK|Gene=CHRM3|UniProtKB=P49578	Muscarinic acetylcholine receptor M3	TAS	8100450	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00047	PDGF signaling pathway	P01142	p90RSK	DROME|FlyBase=FBgn0020412|UniProtKB=Q9V3I5	Chromosomal serine/threonine-protein kinase JIL-1	ISS			PTHR24351:SF175	CHROMOSOMAL SERINE/THREONINE-PROTEIN KINASE JIL-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	IC	15737619	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	TAS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00021	FGF signaling pathway	P00646	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	IPI	14707121	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00034	Integrin signalling pathway	P00922	Collagen	BOVIN|Ensembl=ENSBTAG00000011802|UniProtKB=E1BI98	Uncharacterized protein	ISS	10727440	PubMed	PTHR44172:SF3	COLLAGEN ALPHA-1 VI  CHAIN
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00059	p53 pathway	P04614	Cyclin B	DROME|FlyBase=FBgn0000405|UniProtKB=P20439	G2/mitotic-specific cyclin-B	IDA	90242399	PubMed	PTHR10177:SF347	G2/MITOTIC-SPECIFIC CYCLIN-B
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	BOVIN|Ensembl=ENSBTAG00000009245|UniProtKB=Q0P594	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00047	PDGF signaling pathway	P01160	IP3 receptor	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01067	AChE	BOVIN|Ensembl=ENSBTAG00000011139|UniProtKB=P32749	Cholinesterase	ISS	87080761	PubMed	PTHR43918:SF5	CHOLINESTERASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000012778|UniProtKB=H2QJ75	Phosphoinositide phospholipase C	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05918	p38 MAPK pathway	P06039	MSK2	PANTR|Ensembl=ENSPTRG00000003839|UniProtKB=H2Q401	Ribosomal protein S6 kinase	ISS	9792677	PubMed	PTHR24351:SF41	RIBOSOMAL PROTEIN S6 KINASE ALPHA-4
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	CANLF|Ensembl=ENSCAFG00000004930|UniProtKB=E2RFB5	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00024	Glycolysis	P00672	Phosphofructokinase-1	RAT|RGD=68419|UniProtKB=P47858	ATP-dependent 6-phosphofructokinase, muscle type	RCA			PTHR13697:SF13	ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE, MUSCLE TYPE
P00010	B cell activation	P00376	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P02728	Arginine biosynthesis	P02840	Argininosuccinate synthase	HALSA|EnsemblGenome=VNG_2437G|UniProtKB=Q9HMQ2	Argininosuccinate synthase	ISS			PTHR11587:SF2	ARGININOSUCCINATE SYNTHASE
P00018	EGF receptor signaling pathway	P00558	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=1921305|UniProtKB=Q8K4S1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS			PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00587	Raf-1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00373	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01202	p85	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04398	p53 pathway feedback loops 2	P04665	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00552	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P02772	Pyruvate metabolism	P03139	Lactate Dehydrogenase	TRIVA|Gene=TVAG_239990|UniProtKB=A2EFE2	Lactate dehydrogenase isozyme 2, putative	ISS	12044143	gi	PTHR23382:SF0	MALATE DEHYDROGENASE 2, MITOCHONDRIAL-RELATED
P00029	Huntington disease	P00789	PSD-95	MONDO|Ensembl=ENSMODG00000006427|UniProtKB=F7EZ93	Uncharacterized protein (Fragment)	ISS	12932731	PubMed	PTHR23119:SF33	DISKS LARGE HOMOLOG 4
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00047	PDGF signaling pathway	P01168	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	129387	gi	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00029	Huntington disease	P00794	Hippi	HUMAN|HGNC=17367|UniProtKB=Q9NWB7	Intraflagellar transport protein 57 homolog	IDA	11788820	PubMed	PTHR16011:SF0	INTRAFLAGELLAR TRANSPORT PROTEIN 57 HOMOLOG
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00056	VEGF signaling pathway	P01415	MAPKAPK2/3	BOVIN|Ensembl=ENSBTAG00000038107|UniProtKB=F1MCX5	Uncharacterized protein	ISS	8262198	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00021	FGF signaling pathway	P00645	Rac	ARATH|TAIR=AT1G20090|UniProtKB=Q38919	Rac-like GTP-binding protein ARAC4	ISS			PTHR24072:SF194	RAC-LIKE GTP-BINDING PROTEIN ARAC4-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05917	Opioid proopiomelanocortin pathway	P06008	ACTH	RAT|RGD=3366|UniProtKB=P01194	Pro-opiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	TAKRU|Ensembl=ENSTRUG00000007253|UniProtKB=H2SZQ1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00017	DNA replication	P00527	Histones	BOVIN|Ensembl=ENSBTAG00000045914|UniProtKB=G3MYD7	Histone H3	ISS	20448842	PubMed	PTHR11426:SF179	HISTONE H3.3
P05731	GABA-B receptor II signaling	P05760	AC	PANTR|Ensembl=ENSPTRG00000020589|UniProtKB=H2QWQ6	Uncharacterized protein	ISS	12890691	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P05915	Opioid proenkephalin pathway	P05994	G-protein	ORNAN|Ensembl=ENSOANG00000003489|UniProtKB=F7FSE3	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00053	T cell activation	P01298	NFkappaB	MACMU|Ensembl=ENSMMUG00000002990|UniProtKB=F7GVV0	Uncharacterized protein	ISS	12574369	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00079	alpha7 nicotinic acetylcholine receptor	CAEEL|WormBase=WBGene00000050|UniProtKB=P91197	AcetylCholine Receptor	IDA			PTHR18945:SF436	ACETYLCHOLINE RECEPTOR
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00018	EGF receptor signaling pathway	P00564	Rac	DANRE|ZFIN=ZDB-GENE-030131-3402|UniProtKB=Q803L7	Ras homolog gene family, member Gc	ISS			PTHR24072:SF150	RAS HOMOLOG GENE FAMILY, MEMBER GA-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00931	Integrin beta	MOUSE|MGI=MGI=96616|UniProtKB=P26011	Integrin beta-7	IDA	12391210	PubMed	PTHR10082:SF36	INTEGRIN BETA-7
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00643	Raf-1	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS			PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	CAEBR|Gene=CBG05718|UniProtKB=A8X1T4	Inosine-5'-monophosphate dehydrogenase	ISS			PTHR11911:SF111	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE
P00036	Interleukin signaling pathway	P00968	Ikk	BOVIN|Ensembl=ENSBTAG00000007599|UniProtKB=Q95KV0	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P06664	Gonadotropin-releasing hormone receptor pathway	P06812	L-type Ca2+	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	RCA	10514528	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	CANLF|Ensembl=ENSCAFG00000013102|UniProtKB=Q8HZM5	Glutamine synthetase	ISS			PTHR20852:SF45	GLUTAMINE SYNTHETASE
P00006	Apoptosis signaling pathway	P00269	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	8787761	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	PANTR|Gene=CXCR2|UniProtKB=Q28807	C-X-C chemokine receptor type 2 (Fragment)	ISS	4504683	gi	PTHR10489:SF689	C-X-C CHEMOKINE RECEPTOR TYPE 2
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00023	General transcription regulation	P00658	TBP-associated factors	ANOGA|EnsemblGenome=AGAP005731|UniProtKB=A7UTV1	AGAP005731-PA (Fragment)	ISS			PTHR15137:SF9	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2
P00052	TGF-beta signaling pathway	P01275	P38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04665	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00965	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	MACMU|Ensembl=ENSMMUG00000017654|UniProtKB=F6UI32	Beta-arrestin-2 isoform 1	ISS	12464600	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00012	Cadherin signaling pathway	P00474	Wnt	MACMU|Ensembl=ENSMMUG00000015709|UniProtKB=F6SLX4	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DANRE|ZFIN=ZDB-GENE-040426-1178|UniProtKB=Q7SY24	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02723	Adenine and hypoxanthine salvage pathway	P02804	Hypoxanthine phosphoribosyl transferase	THEMA|EnsemblGenome=TM_0206|UniProtKB=Q9WY49	Hypoxanthine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00048	PI3 kinase pathway	P01199	Galpha	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	DEIRA|EnsemblGenome=DR_1522|UniProtKB=Q9RU71	Pyrroline-5-carboxylate reductase	ISS			PTHR11645:SF0	PYRROLINE-5-CARBOXYLATE REDUCTASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	PANTR|Ensembl=ENSPTRG00000004218|UniProtKB=H2Q4N0	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF137	NEUTROPHIL COLLAGENASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	ORNAN|Ensembl=ENSOANG00000010658|UniProtKB=F6V2V1	Uncharacterized protein	ISS	6755374	gi	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00006	Apoptosis signaling pathway	P00312	MKK7	HUMAN|HGNC=6847|UniProtKB=O14733	Dual specificity mitogen-activated protein kinase kinase 7	ISS			PTHR24361:SF387	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7
P00048	PI3 kinase pathway	P01192	p110	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00021	FGF signaling pathway	P00632	Akt	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	ISS	21291563	gi	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P06210	Activin beta signaling pathway	P06238	FUR1	DROME|FlyBase=FBgn0004509|UniProtKB=P26016	Furin-like protease 1, isoforms 1/1-X/2	IEA	10956649	PubMed	PTHR42884:SF3	FURIN-LIKE PROTEASE 1, ISOFORMS 1/1-X/2
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DICDI|dictyBase=DDB_G0268744|UniProtKB=Q55EU6	Putative actin-23	IDA	10974003	PubMed	PTHR11937:SF154	ACTIN-17-RELATED
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04393	Ras Pathway	P04572	JNK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	ISS	10851062	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00182	p38MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00056	VEGF signaling pathway	P01407	Erk	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02751	Lysine biosynthesis	P03010	Diaminopimelate epimerase	BACTN|EnsemblGenome=BT_0548|UniProtKB=Q8AAB7	Diaminopimelate epimerase	RCA			PTHR31689:SF0	DIAMINOPIMELATE EPIMERASE, CHLOROPLASTIC
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P02788	Xanthine and guanine salvage pathway	P03245	Guanine phosphoribosyl transferase	CAEEL|WormBase=WBGene00013690|UniProtKB=Q9NF11	Hypoxanthine PhosphoRibosylTransferase homolog	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P05915	Opioid proenkephalin pathway	P05992	met-Enkephalin	BOVIN|Ensembl=ENSBTAG00000004924|UniProtKB=P01211	Proenkephalin-A	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00034	Integrin signalling pathway	P00906	Rap1	HUMAN|HGNC=9857|UniProtKB=P61224	Ras-related protein Rap-1b	IPI	8576107	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	DANRE|ZFIN=ZDB-GENE-040426-1354|UniProtKB=Q7T2C5	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00029	Huntington disease	P00790	beta-Tubulin	PHYPA|Gene=PHYPADRAFT_121199|UniProtKB=A9RY37	Predicted protein	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00021	FGF signaling pathway	P00647	SHP2	MACMU|Ensembl=ENSMMUG00000013253|UniProtKB=F6ZJD8	Tyrosine-protein phosphatase non-receptor type	ISS	7681589	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00012	Cadherin signaling pathway	P00470	F-actin	CHICK|Gene=ACTA2|UniProtKB=P08023	Actin, aortic smooth muscle	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P06664	Gonadotropin-releasing hormone receptor pathway	P06779	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	RCA	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00385	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00059	p53 pathway	P01485	p53	MACMU|Ensembl=ENSMMUG00000016466|UniProtKB=F7GBH1	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	15313841	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00005	Angiogenesis	P00227	PLA2	PANTR|Ensembl=ENSPTRG00000001787|UniProtKB=H2Q0T0	Phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02759	Pyridoxal-5-phosphate biosynthesis	P03058	Phosphohydroxythreonine aminotransferase	RHOBA|EnsemblGenome=RB6246|UniProtKB=Q7UQL3	Phosphoserine aminotransferase	ISS			PTHR43247:SF2	PHOSPHOSERINE AMINOTRANSFERASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00566	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04567	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IDA	14526383	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	RAT|RGD=1304887|UniProtKB=D3ZPL7	Down syndrome cell adhesion molecule-like 1 (Predicted)	ISS			PTHR44107:SF3	DOWN SYNDROME CELL ADHESION MOLECULE-LIKE PROTEIN 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	MACMU|Ensembl=ENSMMUG00000023790|UniProtKB=F7HT93	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P00010	B cell activation	P00379	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00034	Integrin signalling pathway	P00924	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IDA	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000018563|UniProtKB=F6YMF6	Uncharacterized protein	ISS	12181435	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P00019	Endothelin signaling pathway	P00566	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00648	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00056	VEGF signaling pathway	P01425	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	8132661	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00010	B cell activation	P00401	jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05960	VAT2	HUMAN|HGNC=10935|UniProtKB=Q05940	Synaptic vesicular amine transporter	IC	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00037	Ionotropic glutamate receptor pathway	P01015	Glu4	RAT|RGD=61863|UniProtKB=P19493	Glutamate receptor 4	ISS	12497607	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	RAT|RGD=621561|UniProtKB=Q9ERC1	Unconventional myosin-XVI	IC			PTHR13140:SF345	UNCONVENTIONAL MYOSIN-XVI
P00037	Ionotropic glutamate receptor pathway	P01026	KA	RAT|RGD=2734|UniProtKB=Q01812	Glutamate receptor ionotropic, kainate 4	ISS	12778120	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	ORNAN|Ensembl=ENSOANG00000005936|UniProtKB=F6PQC9	Uncharacterized protein	ISS	1904317	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00006	Apoptosis signaling pathway	P00318	PKCs	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	IGI	94131270	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	MACMU|Ensembl=ENSMMUG00000030822|UniProtKB=F7A4V2	Uncharacterized protein	ISS			PTHR11482:SF42	ORNITHINE DECARBOXYLASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00139	E-cadherin transmembrane fragment	MACMU|Ensembl=ENSMMUG00000010393|UniProtKB=F7D992	Uncharacterized protein	ISS	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P02738	De novo purine biosynthesis	P02894	IMP cyclohydrolase	METAC|EnsemblGenome=MA_4012|UniProtKB=Q8TIX7	Phosphoribosylaminoimidazolecarboxamide formyltransferase	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P00054	Toll receptor signaling pathway	P01357	MEKK1	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	ISS	12168099	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00021	FGF signaling pathway	P00648	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00010	B cell activation	P00398	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04398	p53 pathway feedback loops 2	P04665	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01465	Ggamma	HUMAN|HGNC=19663|UniProtKB=Q9UBI6	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	ISS	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P02750	Lipoate_biosynthesis	P03004	Lipoate synthase	CANLF|Ensembl=ENSCAFG00000015991|UniProtKB=E2R257	Lipoyl synthase, mitochondrial	ISS			PTHR10949:SF0	LIPOYL SYNTHASE, MITOCHONDRIAL
P00057	Wnt signaling pathway	P01472	Histone deacetylase	PLAF7|EnsemblGenome=PFI1260c|UniProtKB=Q7K6A1	Histone deacetylase	ISS	10485845	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P00037	Ionotropic glutamate receptor pathway	P01018	Glu1	BOVIN|Ensembl=ENSBTAG00000005800|UniProtKB=F1N3G8	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=107436|UniProtKB=P70408	Cadherin-10	IDA	8120095	PubMed	PTHR24027:SF290	CADHERIN-10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00015	Circadian clock system	G01500	bmal1	PANTR|Ensembl=ENSPTRG00000003376|UniProtKB=H2R2H7	Uncharacterized protein	ISS	11163178	PubMed	PTHR23042:SF52	ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 1
P00036	Interleukin signaling pathway	P00986	eNOS	RAT|RGD=3186|UniProtKB=Q62600	Nitric oxide synthase, endothelial	ISS	10435050	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	STRCO|Gene=CAB50757|UniProtKB=Q9XAC4	Uncharacterized protein	ISS			PTHR43785:SF1	TYPE-1 GLUTAMINE SYNTHETASE 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	BOVIN|Ensembl=ENSBTAG00000014583|UniProtKB=P62157	Calmodulin	ISS	7514101	PubMed	PTHR23050:SF335	CALMODULIN, STRIATED MUSCLE
P02781	Threonine biosynthesis	P03189	Aspartate kinase	BACTN|EnsemblGenome=BT_1375|UniProtKB=Q8A7Z9	Aspartokinase	ISS			PTHR21499:SF38	ASPARTOKINASE 1, CHLOROPLASTIC
P00029	Huntington disease	P00778	NMDA receptor	RAT|RGD=2736|UniProtKB=P35439	Glutamate receptor ionotropic, NMDA 1	IDA	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MONDO|Ensembl=ENSMODG00000019262|UniProtKB=F6Q8L1	Receptor protein serine/threonine kinase	ISS	10683140	PubMed	PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P00006	Apoptosis signaling pathway	P00318	PKCs	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P02726	Aminobutyrate degradation	P02825	4-aminobutyrate aminotransferase	RAT|RGD=620948|UniProtKB=P50554	4-aminobutyrate aminotransferase, mitochondrial	ISS	8133261	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00047	PDGF signaling pathway	P01160	IP3 receptor	CAEEL|WormBase=WBGene00002173|UniProtKB=Q9Y0A1	Inositol 1,4,5-trisphosphate receptor itr-1	ISS	4262086	gi	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CAEEL|WormBase=WBGene00006454|UniProtKB=G5EEN8	AEX-4	IC			PTHR19305:SF10	AEX-4
P00020	FAS signaling pathway	P00612	Fas	PANTR|Ensembl=ENSPTRG00000002730|UniProtKB=H2R2U8	Fas (TNF receptor superfamily, member 6)	ISS			PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P00021	FGF signaling pathway	P00639	Shc	MACMU|Ensembl=ENSMMUG00000020357|UniProtKB=F6W915	SHC-transforming protein 3	ISS	9507002	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P00019	Endothelin signaling pathway	P00566	ERK	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00035	Interferon-gamma signaling pathway	P00956	SOCS	MACMU|Ensembl=ENSMMUG00000005384|UniProtKB=F7GUL4	Suppressor of cytokine signaling 5	ISS	22247722	PubMed	PTHR44282:SF3	SUPPRESSOR OF CYTOKINE SIGNALING 5
P00021	FGF signaling pathway	P00645	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	4757952	gi	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00050	Plasminogen activating cascade	P01253	Fibrin	CHICK|Gene=FGB|UniProtKB=Q02020	Fibrinogen beta chain (Fragment)	ISS			PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00019	Endothelin signaling pathway	P00583	cPLA2	ORNAN|Ensembl=ENSOANG00000001027|UniProtKB=F6QDY0	Phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IDA	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05731	GABA-B receptor II signaling	P05752	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04393	Ras Pathway	P04565	MKK4/7	BOVIN|Ensembl=ENSBTAG00000012103|UniProtKB=A5PJP8	MAP2K4 protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00029	Huntington disease	P00786	ARF	MOUSE|MGI=MGI=99435|UniProtKB=P62331	ADP-ribosylation factor 6	ISS	11752622	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00046	Oxidative stress response	P01135	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IDA	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	PANTR|Ensembl=ENSPTRG00000018624|UniProtKB=A6H914	TATA box binding protein-like 1	ISS	600075	OMIM	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05938	RhoA	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	RCA	10556059	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CHICK|Gene=ACTG2|UniProtKB=P63270	Actin, gamma-enteric smooth muscle	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00201	FVIIa	PANTR|Gene=F7|UniProtKB=Q2F9P2	Coagulation factor VII	ISS	4503645	gi	PTHR44064:SF1	COAGULATION FACTOR VII
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00053	T cell activation	P01305	Calmodulin	TAKRU|Ensembl=ENSTRUG00000003442|UniProtKB=H2S6Q5	Uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF197	CALMODULIN-LIKE PROTEIN 3
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	15621031	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00048	PI3 kinase pathway	P01179	PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04567	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	G01579	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	DANRE|ZFIN=ZDB-GENE-990415-45|UniProtKB=P50392	Cytosolic phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	RCA	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	BOVIN|Ensembl=ENSBTAG00000033153|UniProtKB=F1MG21	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00021	FGF signaling pathway	P00627	ERK1-2	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06807	gnai	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00001	Adrenaline and noradrenaline biosynthesis	P00066	DOPA decarb.	CAEBR|Gene=CBG08967|UniProtKB=A8X844	Protein CBR-BAS-1	ISS	90339966	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00807	Actin	PANTR|Ensembl=ENSPTRG00000002086|UniProtKB=H2Q1A9	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	DROME|FlyBase=FBgn0019947|UniProtKB=O02194	Presenilin homolog	TAS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P04393	Ras Pathway	P04569	Cdc42	MACMU|Ensembl=ENSMMUG00000022009|UniProtKB=F6RBZ7	Cell division control protein 42 homolog isoform 2	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	HUMAN|HGNC=15488|UniProtKB=Q9NPF7	Interleukin-23 subunit alpha	IC	11114383	PubMed	PTHR15947:SF0	INTERLEUKIN-23 SUBUNIT ALPHA
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00060	Ubiquitin proteasome pathway	P01491	E2	MACMU|Ensembl=ENSMMUG00000019825|UniProtKB=F7FXQ4	Uncharacterized protein	ISS			PTHR24068:SF36	UBIQUITIN-CONJUGATING ENZYME E2 D1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00048	PI3 kinase pathway	G01545	scl-1	CAEEL|WormBase=WBGene00017183|UniProtKB=O16575	SCP-Like extracellular protein	ISS			PTHR10334:SF256	SCP-LIKE EXTRACELLULAR PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	MOUSE|MGI=MGI=891996|UniProtKB=Q8C196	Carbamoyl-phosphate synthase [ammonia], mitochondrial	ISS			PTHR11405:SF38	CARBAMOYL-PHOSPHATE SYNTHASE  AMMONIA , MITOCHONDRIAL
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MOUSE|MGI=MGI=1354694|UniProtKB=Q9JL25	Regulator of G-protein signaling 1	IDA	10779778	PubMed	PTHR10845:SF34	REGULATOR OF G-PROTEIN SIGNALING 1
P04393	Ras Pathway	P04557	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00238	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00056	VEGF signaling pathway	P01418	Paxillin	MOUSE|MGI=MGI=108295|UniProtKB=Q8VI36	Paxillin	IDA	9182576	PubMed	PTHR24216:SF11	PAXILLIN
P00012	Cadherin signaling pathway	P00474	Wnt	TAKRU|Ensembl=ENSTRUG00000016522|UniProtKB=H2UZ46	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MACMU|Ensembl=ENSMMUG00000009054|UniProtKB=F7F735	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P02788	Xanthine and guanine salvage pathway	P03250	Guanosine phosphorylase	MACMU|Ensembl=ENSMMUG00000019126|UniProtKB=F6T0Z6	Purine nucleoside phosphorylase	ISS			PTHR11904:SF12	PURINE NUCLEOSIDE PHOSPHORYLASE
P00057	Wnt signaling pathway	P01465	Ggamma	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	RAT|RGD=1359485|UniProtKB=Q5U302	Catenin (Cadherin associated protein), alpha 1	ISS	10456847	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00037	Ionotropic glutamate receptor pathway	P01026	KA	CANLF|Ensembl=ENSCAFG00000004930|UniProtKB=E2RFB5	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04398	p53 pathway feedback loops 2	P04662	cyclin G	MOUSE|MGI=MGI=102890|UniProtKB=P51945	Cyclin-G1	ISS	7957050	PubMed	PTHR10177:SF59	CYCLIN-G1
P00005	Angiogenesis	P00227	PLA2	MACMU|Ensembl=ENSMMUG00000021423|UniProtKB=F7EEZ1	Phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_115566|UniProtKB=C3XYC8	Putative uncharacterized protein	IDA	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P06664	Gonadotropin-releasing hormone receptor pathway	P06834	MAP3Ks	MOUSE|MGI=MGI=1346875|UniProtKB=O08648	Mitogen-activated protein kinase kinase kinase 4	RCA	9079650	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00045	Notch signaling pathway	P01112	CoR	RAT|RGD=1310293|UniProtKB=D3ZXN9	Nuclear receptor co-repressor 2 (Predicted), isoform CRA_a	ISS	11112321	PubMed	PTHR13992:SF21	NUCLEAR RECEPTOR COREPRESSOR 2
P00034	Integrin signalling pathway	P00944	Actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	ISS	3487386	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00029	Huntington disease	P00811	Arp2/3 complex	ORNAN|Ensembl=ENSOANG00000007724|UniProtKB=F6QTB5	Uncharacterized protein	ISS	12963527	gi	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00006	Apoptosis signaling pathway	P00260	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00379	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	CAEEL|WormBase=WBGene00006577|UniProtKB=B2D6P4	TBP-Like Factor	ISS	600075	OMIM	PTHR10126:SF13	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	LEIMA|EnsemblGenome=LmjF.13.1680|UniProtKB=Q4QFY6	Pyrroline-5-carboxylate reductase	ISS			PTHR11645:SF0	PYRROLINE-5-CARBOXYLATE REDUCTASE
P00004	Alzheimer disease-presenilin pathway	P00111	C99	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000012036|UniProtKB=F7ALP1	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00054	Toll receptor signaling pathway	P01368	MKK2	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00019	Endothelin signaling pathway	P00589	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05918	p38 MAPK pathway	P06037	TAK1	HUMAN|HGNC=6859|UniProtKB=O43318	Mitogen-activated protein kinase kinase kinase 7	RCA	10683140	PubMed	PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P04398	p53 pathway feedback loops 2	P04665	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	RCA	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=5294|UniProtKB=P41595	5-hydroxytryptamine receptor 2B	IDA			PTHR24247:SF31	5-HYDROXYTRYPTAMINE RECEPTOR 2B
P05917	Opioid proopiomelanocortin pathway	P06009	K+ channel	HUMAN|HGNC=6283|UniProtKB=Q9NPC2	Potassium channel subfamily K member 9	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00019	Endothelin signaling pathway	P00591	PLCbeta	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00056	VEGF signaling pathway	P01407	Erk	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00035	Interferon-gamma signaling pathway	P00960	PTP	MOUSE|MGI=MGI=99511|UniProtKB=P35235	Tyrosine-protein phosphatase non-receptor type 11	TAS	14534538	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	BOVIN|Ensembl=ENSBTAG00000002647|UniProtKB=Q2KHW7	Regulator of G-protein signaling 10	ISS	8756726	PubMed	PTHR10845:SF182	REGULATOR OF G-PROTEIN SIGNALING 10
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	11832947	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00057	Wnt signaling pathway	P01444	Wnt	BRAFL|Gene=BRAFLDRAFT_118160|UniProtKB=C3Z2P0	Protein Wnt	IDA	8717036	PubMed	PTHR12027:SF77	PROTEIN WNT-5
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06769	Gbeta	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P02723	Adenine and hypoxanthine salvage pathway	P02808	Deoxyadenosine phosphorylase	MOUSE|MGI=MGI=3712328|UniProtKB=Q9D8C9	Purine nucleoside phosphorylase	ISS	7903568	PubMed	PTHR11904:SF12	PURINE NUCLEOSIDE PHOSPHORYLASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	MONDO|Ensembl=ENSMODG00000014746|UniProtKB=F6YN64	Uncharacterized protein (Fragment)	ISS	12871085	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	XENTR|Xenbase=XB-GENE-961282|UniProtKB=Q6DF43	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	HUMAN|HGNC=20093|UniProtKB=Q8N142	Adenylosuccinate synthetase isozyme 1	ISS	10636885	PubMed	PTHR11846:SF2	ADENYLOSUCCINATE SYNTHETASE ISOZYME 1
P04393	Ras Pathway	P04547	Ras	DANRE|ZFIN=ZDB-GENE-990415-166|UniProtKB=P79737	GTPase NRas	IDA	9116869	PubMed	PTHR24070:SF189	GTPASE NRAS
P00034	Integrin signalling pathway	P00941	Integrin alpha	RAT|Ensembl=ENSRNOG00000058111|UniProtKB=A0A0G2K470	Protein Itga2	ISS	3487386	PubMed	PTHR23220:SF23	INTEGRIN ALPHA-2
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=12784|UniProtKB=P41221	Protein Wnt-5a	IDA	11266476	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00005	Angiogenesis	P00230	PDGFR	CANLF|Gene=PDGFRB|UniProtKB=Q6QNF3	Platelet-derived growth factor receptor beta	ISS	12374780	PubMed	PTHR24416:SF53	PLATELET-DERIVED GROWTH FACTOR RECEPTOR BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CAEEL|WormBase=WBGene00006454|UniProtKB=G5EEN8	AEX-4	IC			PTHR19305:SF10	AEX-4
P05731	GABA-B receptor II signaling	P05752	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01143	ERK	RAT|RGD=628675|UniProtKB=Q9Z2A6	Mitogen-activated protein kinase 15	ISS	10851062	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00053	T cell activation	P01304	Csk	RAT|RGD=1308800|UniProtKB=P32577	Tyrosine-protein kinase CSK	IDA	12665526	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	PANTR|Ensembl=ENSPTRG00000014849|UniProtKB=H2R3S4	Uncharacterized protein	ISS			PTHR10489:SF655	C-C CHEMOKINE RECEPTOR-LIKE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CAEEL|WormBase=WBGene00000067|UniProtKB=O45815	ACTin	IC	14684598	PubMed	PTHR11937:SF352	ACTIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IDA	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CHICK|Ensembl=ENSGALG00000014539|UniProtKB=F1N861	Uncharacterized protein	ISS	1321498	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=1351345|UniProtKB=P47743	Metabotropic glutamate receptor 8	IDA	9407094	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P04395	Vasopressin synthesis	P04596	Endo Peptidase	ORYSJ|EnsemblGenome=OS01G0108200|UniProtKB=Q658B2	Os01g0108200 protein	IC	9695945	PubMed	PTHR42881:SF2	PROLYL ENDOPEPTIDASE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00018	EGF receptor signaling pathway	P00539	14-3-3	XENTR|Xenbase=XB-GENE-970616|UniProtKB=Q6P4Z5	14-3-3 protein zeta	ISS	12865427	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00047	PDGF signaling pathway	P01167	Ets	MOUSE|MGI=MGI=1270840|UniProtKB=O70273	ETS homologous factor	ISS	15298723	PubMed	PTHR11849:SF171	ETS HOMOLOGOUS FACTOR
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	IDA	11956331	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00020	FAS signaling pathway	P00605	Pro-Caspase7	PANTR|Ensembl=ENSPTRG00000002952|UniProtKB=H2Q2L2	Uncharacterized protein	ISS	14583630	PubMed	PTHR10454:SF31	CASPASE-7
P00018	EGF receptor signaling pathway	P00539	14-3-3	SCHMA|EnsemblGenome=Smp_002410|UniProtKB=Q95W36	14-3-3 epsilon 2	IGI	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P02770	Pyridoxal phosphate salvage pathway	P03120	Pyridoxamine-5-phosphate oxidase	MOUSE|MGI=MGI=2144151|UniProtKB=Q91XF0	Pyridoxine-5'-phosphate oxidase	ISS	14697241	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00047	PDGF signaling pathway	P01153	GSK3	ARATH|TAIR=AT5G26751|UniProtKB=P43288	Shaggy-related protein kinase alpha	ISS	7529201	PubMed	PTHR24057:SF13	SHAGGY-RELATED PROTEIN KINASE ALPHA-RELATED
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	CANLF|Gene=PSEN1|UniProtKB=Q6RH31	Presenilin-1	TAS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01411	Ras	DICPU|Gene=DICPUDRAFT_92731|UniProtKB=F0ZWE6	Putative uncharacterized protein rasG	ISS	89128893	PubMed	PTHR24070:SF282	RAS GTPASE-RELATED
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00641	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P02765	Phenylalanine biosynthesis	P03100	Chorismate mutase	STRCO|Gene=CAB52826|UniProtKB=Q9S238	Putative chorismate mutase	ISS			PTHR21164:SF0	SUBFAMILY NOT NAMED
P02748	Isoleucine biosynthesis	P02994	Branched chain amino acid aminotransferase	BACSU|EnsemblGenome=BSU38550|UniProtKB=P39576	Branched-chain-amino-acid aminotransferase 2	ISS			PTHR11825:SF44	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00021	FGF signaling pathway	P00624	14-3-3	RAT|RGD=61998|UniProtKB=P35213	14-3-3 protein beta/alpha	ISS	1671102	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00045	Notch signaling pathway	P01099	Notch	PANTR|Ensembl=ENSPTRG00000010617|UniProtKB=H2QFL8	Notch 3	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00047	PDGF signaling pathway	P01171	PLCgamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00054	Toll receptor signaling pathway	P01352	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00045	Notch signaling pathway	P01112	CoR	MOUSE|MGI=MGI=1914185|UniProtKB=Q9DA19	Corepressor interacting with RBPJ 1	TAS	11112321	PubMed	PTHR13151:SF2	COREPRESSOR INTERACTING WITH RBPJ 1
P00054	Toll receptor signaling pathway	P01354	NFkappaB	MACMU|Ensembl=ENSMMUG00000002990|UniProtKB=F7GVV0	Uncharacterized protein	ISS	9133421	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00053	T cell activation	P01294	NFAT	RAT|RGD=1310749|UniProtKB=D3Z9H7	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	ISS	12787506	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P04395	Vasopressin synthesis	P04593	Glycopeptide	RAT|RGD=3238|UniProtKB=P01179	Oxytocin-neurophysin 1	IC	192340	OMIM	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	IXOSC|EnsemblGenome=ISCW024111|UniProtKB=B7PBG2	Actin, putative (Fragment)	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00057	Wnt signaling pathway	P01443	Phospholipase C	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MACMU|Ensembl=ENSMMUG00000015717|UniProtKB=F6SFA9	Serotonin receptor type 1B	ISS	11454663	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P00005	Angiogenesis	P00254	GTPase	BOVIN|Ensembl=ENSBTAG00000014299|UniProtKB=Q1RMJ6	Rho-related GTP-binding protein RhoC	ISS	14871999	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00021	FGF signaling pathway	P00627	ERK1-2	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00049	Parkinson disease	P01234	GRK	DROME|FlyBase=FBgn0260798|UniProtKB=P32865	G protein-coupled receptor kinase 1	IDA	10852916	PubMed	PTHR24355:SF18	PROTEIN-SERINE/THREONINE KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	CAEEL|WormBase=WBGene00009119|UniProtKB=Q93576	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00034	Integrin signalling pathway	P00925	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IDA	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=12786|UniProtKB=O00755	Protein Wnt-7a	IDA	12549854	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=2685045|UniProtKB=E9QAN8	Protein Pik3c2b	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00057	Wnt signaling pathway	P01429	Axin	MOUSE|MGI=MGI=1096327|UniProtKB=O35625	Axin-1	ISS	12356903	PubMed	PTHR10845:SF11	AXIN-1
P00049	Parkinson disease	P01241	TH	MOUSE|MGI=MGI=98735|UniProtKB=P24529	Tyrosine 3-monooxygenase	TAS	191290	OMIM	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00057	Wnt signaling pathway	P01428	Frizzled	CANLF|Ensembl=ENSCAFG00000008293|UniProtKB=E2R9M9	Uncharacterized protein	ISS	12549854	PubMed	PTHR11309:SF22	FRIZZLED-3
P05915	Opioid proenkephalin pathway	P05994	G-protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	ISS	12488551	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	BOVIN|Ensembl=ENSBTAG00000018989|UniProtKB=A5D7D8	GRM3 protein	ISS	20012997	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00892	Grb2	CAEBR|Gene=CBG16856|UniProtKB=A8XPY6	Protein CBR-SEM-5	ISS	51702266	gi	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00004	Alzheimer disease-presenilin pathway	P00165	E-cadherin N-terminal fragment	PANTR|Ensembl=ENSPTRG00000008270|UniProtKB=H2QBE5	Uncharacterized protein	ISS	11953314	PubMed	PTHR24027:SF319	CADHERIN-1
P00034	Integrin signalling pathway	P00924	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P04393	Ras Pathway	P04546	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00019	Endothelin signaling pathway	P00567	PKG	PANTR|Ensembl=ENSPTRG00000016212|UniProtKB=H2QPS4	cGMP-dependent protein kinase	ISS	22181250	PubMed	PTHR24353:SF24	SUBFAMILY NOT NAMED
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02746	Heme biosynthesis	P02979	porphobilinogen synthase	SCHPO|PomBase=SPAC1805.06c|UniProtKB=P78974	Delta-aminolevulinic acid dehydratase	ISS			PTHR11458:SF0	DELTA-AMINOLEVULINIC ACID DEHYDRATASE
P00034	Integrin signalling pathway	P00924	Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	IPI	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00029	Huntington disease	P00790	beta-Tubulin	CANLF|Ensembl=ENSCAFG00000018832|UniProtKB=E2QYC2	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00736	CalDAG-GEF	RAT|RGD=1304612|UniProtKB=A0A0G2KAU4	Protein Rasgrp3	ISS	10835426	PubMed	PTHR23113:SF178	RAS GUANYL-RELEASING PROTEIN 3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CAEBR|Gene=CBG18256|UniProtKB=A8XS95	Protein CBR-ACT-5	ISS	14684598	PubMed	PTHR11937:SF352	ACTIN
P00034	Integrin signalling pathway	P00951	Jnk	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00049	Parkinson disease	P01208	Hsp70	DICDI|dictyBase=DDB_G0269144|UniProtKB=P36415	Heat shock cognate 70 kDa protein 1	IDA	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00047	PDGF signaling pathway	P01167	Ets	MONDO|Ensembl=ENSMODG00000004730|UniProtKB=F6Y1Z2	Uncharacterized protein	ISS	15579511	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	RAT|RGD=2732|UniProtKB=P22756	Glutamate receptor ionotropic, kainate 1	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00759	PDEalphabeta	ORNAN|Ensembl=ENSOANG00000009367|UniProtKB=F7G5L8	Phosphodiesterase	ISS	7493036	PubMed	PTHR11347:SF115	ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P06587	Nicotine pharmacodynamics pathway	P06596	Grb2	XENTR|Xenbase=XB-GENE-6070000|UniProtKB=Q66II3	Growth factor receptor-bound protein 2	ISS	12748278	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00012	Cadherin signaling pathway	P00468	Src	RAT|RGD=620795|UniProtKB=Q9WUD9	Proto-oncogene tyrosine-protein kinase Src	ISS	8054685	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P02743	Formyltetrahydroformate biosynthesis	P02954	Thymidylate synthase	PANTR|Ensembl=ENSPTRG00000009822|UniProtKB=G2HEY4	Fibronectin 1	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00628	JNK1-3	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00182	p38MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	CANLF|Ensembl=ENSCAFG00000002617|UniProtKB=E2QUL1	Uncharacterized protein	ISS	14698601	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	MONDO|Ensembl=ENSMODG00000012761|UniProtKB=F6SJA3	Tyrosine-protein kinase receptor (Fragment)	ISS	6754360	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00023	General transcription regulation	P00662	TFIIA complex	YEAST|SGD=S000001541|UniProtKB=P32774	Transcription initiation factor IIA subunit 2	ISS			PTHR10966:SF0	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00018	EGF receptor signaling pathway	P00563	Gab	MOUSE|MGI=MGI=108088|UniProtKB=Q9QYY0	GRB2-associated-binding protein 1	IGI	20885508	gi	PTHR12156:SF18	GRB2-ASSOCIATED-BINDING PROTEIN 1
P00018	EGF receptor signaling pathway	P00559	MEK1-2	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IGI	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00009	Axon guidance mediated by netrin	P00366	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00018	EGF receptor signaling pathway	P00551	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01275	P38	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	NEUCR|EnsemblGenome=EFNCRG00000005497|UniProtKB=Q8TG12	Casein kinase II subunit beta-1	IDA	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	TAS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00029	Huntington disease	P00790	beta-Tubulin	SCHMA|EnsemblGenome=Smp_192110|UniProtKB=G4VHK8	Putative tubulin beta chain	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	PSEAE|EnsemblGenome=PA1794|UniProtKB=Q9I2U8	Glutamine--tRNA ligase	ISS			PTHR43097:SF5	GLUTAMATE--TRNA LIGASE, CYTOPLASMIC
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	IDA	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	CAEEL|WormBase=WBGene00022455|UniProtKB=Q9N588	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IDA	176910	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00020	FAS signaling pathway	P00604	Pro-Caspase8	MACMU|Ensembl=ENSMMUG00000031296|UniProtKB=F7C587	Uncharacterized protein	ISS	11788820	PubMed	PTHR10454:SF162	CASPASE-8
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000037429|UniProtKB=F1MGM3	Uncharacterized protein	ISS	12181435	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P00019	Endothelin signaling pathway	P00591	PLCbeta	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	IGI	10571227	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-040718-93|UniProtKB=Q6DGZ5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00034	Integrin signalling pathway	P00906	Rap1	DANRE|ZFIN=ZDB-GENE-040625-167|UniProtKB=Q6IQP4	RAP1A, member of RAS oncogene family	ISS	10476970	PubMed	PTHR24070:SF284	RAP1A, MEMBER OF RAS ONCOGENE FAMILY
P02756	N-acetylglucosamine metabolism	P03036	N-acetylglucosamine-6-phosphate deacetylase	THEMA|EnsemblGenome=TM_0814|UniProtKB=Q9WZS1	N-acetylglucosamine-6-phosphate deacetylase	ISS			PTHR11113:SF1	N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00006	Apoptosis signaling pathway	P00269	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00036	Interleukin signaling pathway	P00979	MAPKAPK2	BOVIN|Ensembl=ENSBTAG00000038107|UniProtKB=F1MCX5	Uncharacterized protein	ISS	7923354	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	CAEEL|WormBase=WBGene00001985|UniProtKB=O02100	Presenilin hop-1	TAS	12834808	PubMed	PTHR10202:SF14	PRESENILIN HOP-1
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	CAEEL|WormBase=WBGene00004769|UniProtKB=P52166	Presenilin sel-12	TAS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00030	Hypoxia response via HIF activation	P00821	Prolyl Hydroxylase	HUMAN|HGNC=14661|UniProtKB=Q9H6Z9	Egl nine homolog 3	ISS	12912907	PubMed	PTHR12907:SF5	EGL NINE HOMOLOG 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01188	Gbetagamma	RAT|RGD=69319|UniProtKB=P54313	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	MOUSE|MGI=MGI=97852|UniProtKB=P62835	Ras-related protein Rap-1A	IDA	10476970	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00057	Wnt signaling pathway	P01443	Phospholipase C	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Gene=CHRM2|UniProtKB=Q9N2A7	Muscarinic acetylcholine receptor M2 (Fragment)	ISS	12181435	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P06212	DPP-SCW signaling pathway	P06275	SCW full length	DROME|FlyBase=FBgn0005590|UniProtKB=P54631	Protein screw	IEA	http://flybase.org/reports/FBgn0005590.html	Website	PTHR11848:SF54	PROTEIN 60A-RELATED
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	RAT|RGD=3694|UniProtKB=Q01827	Synaptic vesicular amine transporter	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00047	PDGF signaling pathway	P01145	c-fos	CANLF|Ensembl=ENSCAFG00000017040|UniProtKB=E2QYK5	Uncharacterized protein	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	HUMAN|HGNC=17794|UniProtKB=Q7L0Q8	Rho-related GTP-binding protein RhoU	ISS			PTHR24072:SF148	RHO-RELATED GTP-BINDING PROTEIN RHOU
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00049	Parkinson disease	P01242	Casein kinase I	ORYSJ|EnsemblGenome=OS01G0570500|UniProtKB=Q656Y0	Os01g0570500 protein	IDA	11437445	PubMed	PTHR11909:SF162	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DANRE|ZFIN=ZDB-GENE-030131-172|UniProtKB=Q6IQR3	Actin, alpha, cardiac muscle 1a	IEP	11889126	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00010	B cell activation	P00383	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00060	Ubiquitin proteasome pathway	P01490	E3	ORNAN|Ensembl=ENSOANG00000008046|UniProtKB=F7EF57	Uncharacterized protein	ISS	11252892	PubMed	PTHR11254:SF300	E3 UBIQUITIN-PROTEIN LIGASE SMURF2
P02749	Leucine biosynthesis	P03000	Branched chain amino acid aminotransferase	PYRAE|EnsemblGenome=PAE3297|UniProtKB=Q8ZTE2	Branched-chain amino acid aminotransferase (IlvE)	ISS			PTHR42743:SF3	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE-LIKE PROTEIN 1-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	IDA	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=3765|UniProtKB=P30938	Somatostatin receptor type 5	IDA	12441358	PubMed	PTHR24229:SF20	SOMATOSTATIN RECEPTOR TYPE 5
P05731	GABA-B receptor II signaling	P05755	Gbeta	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	CANLF|Ensembl=ENSCAFG00000015856|UniProtKB=J9P3S5	Nucleoside diphosphate kinase	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P05731	GABA-B receptor II signaling	P05754	Ggamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	BOVIN|Ensembl=ENSBTAG00000035697|UniProtKB=Q28024	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DROME|FlyBase=FBgn0261854|UniProtKB=A1Z9X0	Atypical protein kinase C	ISS	3045562	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	1650351	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00048	PI3 kinase pathway	P01177	P110ACT	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	HUMAN|HGNC=9300|UniProtKB=P62714	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05913	Enkephalin release	P05972	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00983	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00547	PP2A	HUMAN|HGNC=9313|UniProtKB=Q16537	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	ISS	10092233	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00006	Apoptosis signaling pathway	P00288	TNFR1	RAT|RGD=621237|UniProtKB=P22934	Tumor necrosis factor receptor superfamily member 1A	ISS			PTHR23097:SF177	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1A
P00011	Blood coagulation	P00438	Bradykinin	HUMAN|HGNC=6383|UniProtKB=P01042	Kininogen-1	ISS	125507	gi	PTHR13814:SF12	KININOGEN-1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00029	Huntington disease	P00780	Microtubule	TAKRU|Ensembl=ENSTRUG00000000002|UniProtKB=H2RIN9	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF236	SUBFAMILY NOT NAMED
P02747	Histidine biosynthesis	P02987	ATP phosphoribosyl transferase	RHOBA|EnsemblGenome=RB5603|UniProtKB=Q7URL0	ATP phosphoribosyltransferase	ISS			PTHR21403:SF4	ATP PHOSPHORIBOSYLTRANSFERASE
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	9199552	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00053	T cell activation	P01320	PLC-gamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00059	p53 pathway	G04699	BAI-1	MOUSE|MGI=MGI=2441837|UniProtKB=Q80ZF8	Adhesion G protein-coupled receptor B3	ISS			PTHR12011:SF40	ADHESION G PROTEIN-COUPLED RECEPTOR B3
P00047	PDGF signaling pathway	P01171	PLCgamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00011	Blood coagulation	P00443	Fibrin polymer cross-linked	BOVIN|Gene=FGG|UniProtKB=P12799	Fibrinogen gamma-B chain	ISS	120140	gi	PTHR19143:SF338	FIBRINOGEN GAMMA CHAIN
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	RAT|RGD=1307705|UniProtKB=B5DF62	Protein Pak4	ISS			PTHR24361:SF345	SERINE/THREONINE-PROTEIN KINASE PAK 4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05913	Enkephalin release	P05972	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00163	Erb-B4 C-terminal fragment	ORNAN|Ensembl=ENSOANG00000007021|UniProtKB=F7GAV2	Receptor protein-tyrosine kinase	ISS	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00023	General transcription regulation	P00658	TBP-associated factors	HUMAN|HGNC=17306|UniProtKB=Q9HBM6	Transcription initiation factor TFIID subunit 9B	ISS			PTHR12595:SF3	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 9B
P00059	p53 pathway	P04627	E2F-1	XENTR|Xenbase=XB-GENE-974737|UniProtKB=F6VW96	Uncharacterized protein	ISS	20337912	PubMed	PTHR12081:SF44	TRANSCRIPTION FACTOR E2F3
P00046	Oxidative stress response	P01134	cPLA2	CANLF|Ensembl=ENSCAFG00000013778|UniProtKB=F6UQ33	Phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	CANLF|Ensembl=ENSCAFG00000019633|UniProtKB=F1PDC7	Uncharacterized protein	ISS	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00019	Endothelin signaling pathway	P00566	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004886|UniProtKB=H2Q5T7	Calcium channel, voltage-dependent, beta 3 subunit	ISS			PTHR11824:SF8	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-3
P02781	Threonine biosynthesis	P03192	Aspartate semialdehyde dehydrogenase	ECOLI|EcoGene=EG11059|UniProtKB=P08390	USG-1 protein	ISS			PTHR10174:SF2	ASPARTATE-SEMIALDEHYDE DEHYDROGENASE
P00012	Cadherin signaling pathway	P00470	F-actin	STRPU|EnsemblGenome=SPU_012282|UniProtKB=W4Y969	Uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF369	ACTIN-42A
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	RCA	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04398	p53 pathway feedback loops 2	P04651	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00034	Integrin signalling pathway	P00941	Integrin alpha	HUMAN|HGNC=6139|UniProtKB=P26006	Integrin alpha-3	IPI	3487386	PubMed	PTHR23220:SF89	INTEGRIN ALPHA-3
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	MOUSE|MGI=MGI=1923865|UniProtKB=Q7TSV6	Putative aspartate aminotransferase, cytoplasmic 2	ISS			PTHR11879:SF6	ASPARTATE AMINOTRANSFERASE, CYTOPLASMIC 2-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	BOVIN|Gene=KCNJ5|UniProtKB=F1MYR9	G protein-activated inward rectifier potassium channel 4	ISS			PTHR11767:SF52	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 4
P00046	Oxidative stress response	P01135	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00006	Apoptosis signaling pathway	P00326	FAS ligand	MACMU|Gene=FASLG|UniProtKB=P63307	Tumor necrosis factor ligand superfamily member 6	ISS	12787569	PubMed	PTHR11471:SF33	TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 6
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00029	Huntington disease	P00780	Microtubule	CAEEL|WormBase=WBGene00006537|UniProtKB=P52275	Tubulin beta-2 chain	IDA	9454836	PubMed	PTHR11588:SF84	TUBULIN BETA-2 CHAIN
P04393	Ras Pathway	P04572	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IDA	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00018	EGF receptor signaling pathway	P00552	Ras	CHICK|Ensembl=ENSGALG00000006885|UniProtKB=P08642	GTPase HRas	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P05918	p38 MAPK pathway	P06043	ASK1	MACMU|Ensembl=ENSMMUG00000016376|UniProtKB=F7G2W1	Uncharacterized protein	ISS	12968034	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00034	Integrin signalling pathway	P00907	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	IDA	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	MACMU|Ensembl=ENSMMUG00000003962|UniProtKB=F6Z9D7	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00049	Parkinson disease	P01211	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10557357	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00047	PDGF signaling pathway	P01167	Ets	RAT|RGD=1310802|UniProtKB=D4ACQ9	GA repeat binding protein, alpha (Predicted)	ISS	15298723	PubMed	PTHR11849:SF195	GA-BINDING PROTEIN ALPHA CHAIN
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00057	Wnt signaling pathway	P01472	Histone deacetylase	CANLF|Ensembl=ENSCAFG00000010597|UniProtKB=J9NUI0	Histone deacetylase	ISS	10485845	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P04395	Vasopressin synthesis	P04597	Signal Peptide	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P02772	Pyruvate metabolism	P03133	Pyruvate Dehydrogenase	CHLTR|EnsemblGenome=CT_245|UniProtKB=O84247	Pyruvate dehydrogenase E1 component subunit alpha	ISS	15604966	gi	PTHR11516:SF53	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00912	Arp2/3	CHICK|Ensembl=ENSGALG00000003820|UniProtKB=E1C8Y3	Actin-related protein 2/3 complex subunit 3	ISS	12473693	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00019	Endothelin signaling pathway	P00570	PKA	SCHPO|PomBase=SPAC8C9.03|UniProtKB=P36600	cAMP-dependent protein kinase regulatory subunit	ISS	2372396	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00005	Angiogenesis	P00209	FAK	BOVIN|Ensembl=ENSBTAG00000009578|UniProtKB=G3N3B7	Uncharacterized protein	ISS	9182576	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00021	FGF signaling pathway	P00633	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	87226391	PubMed	PTHR24070:SF385	GTPASE HRAS
P00016	Cytoskeletal regulation by Rho GTPase	P00516	Ena/VASP	MOUSE|MGI=MGI=109268|UniProtKB=P70460	Vasodilator-stimulated phosphoprotein	ISS	8836115	PubMed	PTHR11202:SF12	VASODILATOR-STIMULATED PHOSPHOPROTEIN
P00021	FGF signaling pathway	P00642	MEK1-2	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00034	Integrin signalling pathway	P00922	Collagen	MOUSE|MGI=MGI=88460|UniProtKB=Q02788	Collagen alpha-2(VI) chain	IDA	10778855	PubMed	PTHR44172:SF1	COLLAGEN ALPHA-2 VI  CHAIN
P00018	EGF receptor signaling pathway	P00546	GAP	HUMAN|HGNC=7765|UniProtKB=P21359	Neurofibromin	ISS	18587532	gi	PTHR10194:SF60	NEUROFIBROMIN
P04393	Ras Pathway	P04543	MEKK1/4	MACMU|Ensembl=ENSMMUG00000012387|UniProtKB=F7EB20	Uncharacterized protein	ISS	12168099	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P04393	Ras Pathway	P04578	Rho	MONDO|Ensembl=ENSMODG00000000981|UniProtKB=F7ES59	Uncharacterized protein	ISS	12090470	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	HUMAN|HGNC=1966|UniProtKB=Q04844	Acetylcholine receptor subunit epsilon	IC			PTHR18945:SF59	ACETYLCHOLINE RECEPTOR SUBUNIT EPSILON
P00047	PDGF signaling pathway	P01150	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04393	Ras Pathway	P04569	Cdc42	IXOSC|EnsemblGenome=ISCW003614|UniProtKB=B7PHY7	Cdc42 protein, putative	ISS	4757952	gi	PTHR24072:SF192	CDC42 HOMOLOG
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00005	Angiogenesis	P00236	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05752	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	RCA	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00021	FGF signaling pathway	P00628	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	DANRE|ZFIN=ZDB-GENE-000906-4|UniProtKB=B0S5E7	Frizzled homolog 9	TAS	11212302	PubMed	PTHR11309:SF79	FRIZZLED-9
P00054	Toll receptor signaling pathway	P01351	TLR2,4,7	RAT|RGD=3870|UniProtKB=Q9QX05	Toll-like receptor 4	ISS			PTHR44568:SF1	TOLL-LIKE RECEPTOR 4
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	RAT|RGD=1306213|UniProtKB=D3ZQ51	Protein Pak6	ISS			PTHR24361:SF182	SERINE/THREONINE-PROTEIN KINASE PAK 6
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	CAEEL|WormBase=WBGene00006542|UniProtKB=P32085	TATA-box-binding protein	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00034	Integrin signalling pathway	P00928	alpha actinin	BOVIN|Gene=ACTN3|UniProtKB=Q0III9	Alpha-actinin-3	ISS	2116421	PubMed	PTHR43947:SF6	ALPHA-ACTININ-3
P04393	Ras Pathway	P04570	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04651	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	PANTR|Ensembl=ENSPTRG00000008771|UniProtKB=H2QCA0	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF484	MYOSIN-1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P02721	ATP synthesis	P02793	Cytochrome oxidase aa3	BACSU|EnsemblGenome=BSU38160|UniProtKB=P34956	Quinol oxidase subunit 1	TAS	1316894	PubMed	PTHR10422:SF6	SUBFAMILY NOT NAMED
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00547	PP2A	MACMU|Ensembl=ENSMMUG00000019771|UniProtKB=F7APV7	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform 1	ISS	10092233	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00777	CBP	MACMU|Ensembl=ENSMMUG00000000893|UniProtKB=F6T7D0	Histone acetyltransferase p300	ISS	10769018	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	MACMU|Ensembl=ENSMMUG00000012033|UniProtKB=F7GWI2	Serine/threonine-protein kinase PAK 2	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00006	Apoptosis signaling pathway	P00267	MADD	BOVIN|Ensembl=ENSBTAG00000021700|UniProtKB=E1BK67	Uncharacterized protein	ISS	9115275	PubMed	PTHR13008:SF7	MAP KINASE-ACTIVATING DEATH DOMAIN PROTEIN
P00029	Huntington disease	P00810	GAPDH	ARATH|TAIR=AT1G42970|UniProtKB=P25857	Glyceraldehyde-3-phosphate dehydrogenase GAPB, chloroplastic	IPI			PTHR43148:SF1	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE GAPB, CHLOROPLASTIC
P00025	Hedgehog signaling pathway	P00682	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00019	Endothelin signaling pathway	P00586	Gq	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00012	Cadherin signaling pathway	P00470	F-actin	DANRE|ZFIN=ZDB-GENE-030131-55|UniProtKB=Q6XNL8	Actin	IC	11889139	PubMed	PTHR11937:SF263	ACTIN
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05913	Enkephalin release	P05974	G-Protein (i)	SCHPO|PomBase=SPBC32H8.07|UniProtKB=Q10282	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00010	B cell activation	P00385	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00013	Cell cycle	P00480	Proteasome	PANTR|Ensembl=ENSPTRG00000003106|UniProtKB=H2R5P6	Uncharacterized protein	ISS	99239941	PubMed	PTHR10539:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13
P00021	FGF signaling pathway	P00643	Raf-1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01300	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04398	p53 pathway feedback loops 2	P04651	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	BOVIN|Ensembl=ENSBTAG00000015333|UniProtKB=F1MME0	Uncharacterized protein	ISS			PTHR15137:SF9	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2
P05916	Opioid prodynorphin pathway	P05999	provasopressin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT1G07880|UniProtKB=Q9LQQ9	Mitogen-activated protein kinase 13	ISS	10514528	PubMed	PTHR24055:SF185	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00046	Oxidative stress response	P01129	JNK1/2	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00049	Parkinson disease	P01211	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	PANTR|Ensembl=ENSPTRG00000007113|UniProtKB=H2Q9I2	Uncharacterized protein	ISS	14724059	PubMed	PTHR11699:SF102	RETINAL DEHYDROGENASE 2
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P06215	MYO signaling pathway	P06309	LACK	DROME|FlyBase=FBgn0029006|UniProtKB=Q9V853	E3 ubiquitin-protein ligase Smurf1	IEA	11252892	PubMed	PTHR11254:SF395	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00010	B cell activation	P00371	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	PANTR|Ensembl=ENSPTRG00000009552|UniProtKB=H2QDP8	Uncharacterized protein	ISS	9459445	PubMed	PTHR10845:SF170	REGULATOR OF G-PROTEIN SIGNALING 9
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00053	T cell activation	P01332	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00053	T cell activation	P01336	Jnk	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00005	Angiogenesis	P00234	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	11384839	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	YEAST|SGD=S000001295|UniProtKB=P07278	cAMP-dependent protein kinase regulatory subunit	IC	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00631	Grb2	DANRE|ZFIN=ZDB-GENE-040426-1975|UniProtKB=Q6PC73	Growth factor receptor-bound protein 2	ISS	4504111	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00012	Cadherin signaling pathway	P00477	GSK3beta	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00059	p53 pathway	P04613	B99	PANTR|Ensembl=ENSPTRG00000014509|UniProtKB=H2QLW6	G-2 and S-phase expressed 1	ISS	20127556	gi	PTHR21584:SF10	G2 AND S PHASE-EXPRESSED PROTEIN 1
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00059	p53 pathway	P04630	PP2A	STRPU|EnsemblGenome=SPU_025182|UniProtKB=W4ZAK5	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00005	Angiogenesis	P00209	FAK	MOUSE|MGI=MGI=95481|UniProtKB=P34152	Focal adhesion kinase 1	ISS	12640026	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MOUSE|MGI=MGI=96284|UniProtKB=P31387	5-hydroxytryptamine receptor 5B	IDA			PTHR24247:SF14	5-HYDROXYTRYPTAMINE RECEPTOR 5B
P05913	Enkephalin release	P05974	G-Protein (i)	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00059	p53 pathway	P04609	PI3K	CAEEL|WormBase=WBGene00006932|UniProtKB=Q9TXI7	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	21924698	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00005	Angiogenesis	P00206	Wnt	RAT|RGD=1597195|UniProtKB=D4A9J2	Protein Wnt	ISS	14644163	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00053	T cell activation	P01336	Jnk	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	IC	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00059	p53 pathway	P01486	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00223	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00948	Rho	MONDO|Ensembl=ENSMODG00000012981|UniProtKB=F7CS91	Uncharacterized protein	ISS	10556059	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00019	Endothelin signaling pathway	P00586	Gq	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04384	Gamma-aminobutyric acid synthesis	P04480	GABA aminotransferase	SCHPO|PomBase=SPAC19D5.07|UniProtKB=O13837	4-aminobutyrate aminotransferase	ISS	8133261	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CAEEL|WormBase=WBGene00004036|UniProtKB=G5EFI8	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IDA	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	MOUSE|MGI=MGI=99659|UniProtKB=E9PZQ0	Ryanodine receptor 1	ISS	8930069	PubMed	PTHR13715:SF15	RYANODINE RECEPTOR 1
P05918	p38 MAPK pathway	P06042	4E-BP1	PANTR|Ensembl=ENSPTRG00000022700|UniProtKB=H2R0Z1	Uncharacterized protein	ISS	12820960	PubMed	PTHR12669:SF14	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00559	MEK1-2	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	YEAST|SGD=S000005854|UniProtKB=P33328	Synaptobrevin homolog 2	ISS	10414292	PubMed	PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00036	Interleukin signaling pathway	P00970	Interleukin	CANLF|Ensembl=ENSCAFG00000003029|UniProtKB=P41324	Interleukin-8	IC	124361	gi	PTHR10179:SF70	INTERLEUKIN-8
P00029	Huntington disease	P00796	Kainate receptor	BOVIN|Ensembl=ENSBTAG00000033153|UniProtKB=F1MG21	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CHICK|Gene=CHRM4|UniProtKB=P17200	Muscarinic acetylcholine receptor M4	IDA	11166329	PubMed	PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00047	PDGF signaling pathway	P01143	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	12471242	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00060	Ubiquitin proteasome pathway	P01491	E2	SCHPO|PomBase=SPBP16F5.04|UniProtKB=O00102	Ubiquitin-conjugating enzyme E2-18 kDa	ISS			PTHR24067:SF154	UBIQUITIN-CONJUGATING ENZYME E2 G2
P00057	Wnt signaling pathway	P01438	PP2A	MACMU|Ensembl=ENSMMUG00000004873|UniProtKB=F7ANY9	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-040718-134|UniProtKB=Q6DH55	Guanine nucleotide binding protein (G protein), beta polypeptide 3, like	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=2685045|UniProtKB=E9QAN8	Protein Pik3c2b	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P04393	Ras Pathway	P04547	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P00018	EGF receptor signaling pathway	P00561	STAT	HUMAN|HGNC=11367|UniProtKB=P51692	Signal transducer and activator of transcription 5B	IGI	8732682	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	13430383	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	RAT|RGD=1304965|UniProtKB=A0A0G2K6E0	Protein Rhoc	ISS	14871999	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P04392	P53 pathway feedback loops 1	G04685	p73DeltaN	PANTR|Ensembl=ENSPTRG00000015733|UniProtKB=H2QNY5	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00056	VEGF signaling pathway	P01407	Erk	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00019	Endothelin signaling pathway	P00566	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00029	Huntington disease	P00774	Dynein complex	ANOGA|EnsemblGenome=AGAP003271|UniProtKB=Q7PTQ4	AGAP003271-PA	IPI	9454836	PubMed	PTHR10676:SF351	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00006	Apoptosis signaling pathway	P00303	c-Jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00047	PDGF signaling pathway	P01173	STAT	CANLF|Ensembl=ENSCAFG00000015509|UniProtKB=F1PNW8	Signal transducer and activator of transcription	ISS	20119183	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01432	Beta-Catenin	BOVIN|Ensembl=ENSBTAG00000016420|UniProtKB=Q0VCX4	Catenin beta-1	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_115565|UniProtKB=C3XYD3	Putative uncharacterized protein	ISS			PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00539	14-3-3	ORYSJ|EnsemblGenome=OS03G0710800|UniProtKB=Q06967	14-3-3-like protein GF14-F	ISS	10407019	PubMed	PTHR18860:SF40	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00203	Erk	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	MONDO|Ensembl=ENSMODG00000015246|UniProtKB=F6UJF5	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00005	Angiogenesis	P00189	Fzd	PANTR|Ensembl=ENSPTRG00000020122|UniProtKB=H2QVZ0	Uncharacterized protein	ISS	12549854	PubMed	PTHR11309:SF22	FRIZZLED-3
P00057	Wnt signaling pathway	P01456	beta-arrestin	DROME|FlyBase=FBgn0040206|UniProtKB=Q9V393	Kurtz arrestin	IDA	9388255	PubMed	PTHR11792:SF17	KURTZ ARRESTIN
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	HUMAN|HGNC=2514|UniProtKB=P35222	Catenin beta-1	TAS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00018	EGF receptor signaling pathway	P00557	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	ISS	1171954	gi	PTHR10048:SF14	PI-3 KINASE
P00006	Apoptosis signaling pathway	P00269	MAPK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	ISS	6466184	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CANLF|Ensembl=ENSCAFG00000010080|UniProtKB=E2RB62	Uncharacterized protein	ISS			PTHR13140:SF277	UNCONVENTIONAL MYOSIN-IB
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	MONDO|Ensembl=ENSMODG00000014779|UniProtKB=F7G6Y2	Uncharacterized protein	ISS			PTHR11482:SF42	ORNITHINE DECARBOXYLASE
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	ANOGA|EnsemblGenome=AGAP003405|UniProtKB=Q7QDK6	Adenylosuccinate synthetase	IEP	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P05912	Dopamine receptor mediated signaling pathway	P05963	MAO	RAT|RGD=3041|UniProtKB=P19643	Amine oxidase [flavin-containing] B	ISS	8602220	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P00006	Apoptosis signaling pathway	P00260	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IDA	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01465	Ggamma	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00004	Alzheimer disease-presenilin pathway	P00123	CD44 C-terminal fragment	MACMU|Ensembl=ENSMMUG00000004327|UniProtKB=F6ZDZ8	Uncharacterized protein	ISS	14871815	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P00023	General transcription regulation	P00660	RNA Polymerase II	DANRE|ZFIN=ZDB-GENE-030131-6609|UniProtKB=Q7ZV11	Polymerase (RNA) II (DNA directed) polypeptide C	ISS	2187864	PubMed	PTHR11800:SF2	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01162	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00572	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IGI	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00800	PolyQ Htt	RAT|RGD=68337|UniProtKB=P51111	Huntingtin	TAS	7620118	PubMed	PTHR10170:SF10	HUNTINGTIN
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IDA	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00023	General transcription regulation	P00662	TFIIA complex	TAKRU|Ensembl=ENSTRUG00000003740|UniProtKB=H2S8Q9	Transcription initiation factor IIA subunit 2	ISS			PTHR10966:SF0	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00927	Rac	ENTHI|EnsemblGenome=EHI_181250|UniProtKB=C4M5Z7	Rho family GTPase	IGI	8649368	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CRYNJ|EnsemblGenome=CNA04650|UniProtKB=Q5KP06	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00052	TGF-beta signaling pathway	P01288	FKBP12	PANTR|Ensembl=ENSPTRG00000013163|UniProtKB=H2QJT5	Peptidyl-prolyl cis-trans isomerase	ISS			PTHR10516:SF301	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02743	Formyltetrahydroformate biosynthesis	P02954	Thymidylate synthase	CRYNJ|EnsemblGenome=CNJ01230|UniProtKB=P0CS12	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MOUSE|MGI=MGI=95823|UniProtKB=Q03391	Glutamate receptor ionotropic, NMDA 2D	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00056	VEGF signaling pathway	P01417	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	12068308	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00012	Cadherin signaling pathway	P00470	F-actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347742|UniProtKB=E9FZ00	Cytoplasmatic actin	ISS	11889126	PubMed	PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00059	p53 pathway	P04609	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05731	GABA-B receptor II signaling	P05760	AC	BOVIN|Ensembl=ENSBTAG00000018777|UniProtKB=E1BHU9	Uncharacterized protein	ISS	94139935	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P05916	Opioid prodynorphin pathway	P06002	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000003300|UniProtKB=H2Q326	Uncharacterized protein	ISS	8120095	PubMed	PTHR43956:SF6	PROTOCADHERIN-16
P00054	Toll receptor signaling pathway	G01550	Gene trancription	MOUSE|MGI=MGI=97798|UniProtKB=Q05769	Prostaglandin G/H synthase 2	ISS	97122334	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	RAT|RGD=620218|UniProtKB=P15337	Cyclic AMP-responsive element-binding protein 1	ISS	11752053	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00059	p53 pathway	G01579	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00015	Circadian clock system	G01501	cry	RAT|RGD=620935|UniProtKB=Q923I8	Cryptochrome-2	IDA	11804325	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00029	Huntington disease	P00805	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00023	General transcription regulation	P00658	TBP-associated factors	PANTR|Ensembl=ENSPTRG00000008411|UniProtKB=H2QBM1	Uncharacterized protein	ISS	604905	OMIM	PTHR15319:SF1	TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT C
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=69424|UniProtKB=Q99P84	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	12860966	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00029	Huntington disease	P00763	Hip-12	HUMAN|HGNC=17367|UniProtKB=Q9NWB7	Intraflagellar transport protein 57 homolog	IDA			PTHR16011:SF0	INTRAFLAGELLAR TRANSPORT PROTEIN 57 HOMOLOG
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DROME|FlyBase=FBgn0000489|UniProtKB=P16912	Protein kinase DC2	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	RAT|RGD=62030|UniProtKB=P02564	Myosin-7	IC	10938134	PubMed	PTHR13140:SF344	MYOSIN-7
P05916	Opioid prodynorphin pathway	P05999	provasopressin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	USTMA|Gene=UMAG_11232|UniProtKB=A0A0D1DMT3	Chromosome 22, whole genome shotgun sequence	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00052	TGF-beta signaling pathway	P01281	SARA	MACMU|Ensembl=ENSMMUG00000023177|UniProtKB=F7EJM7	Uncharacterized protein	ISS			PTHR22835:SF43	ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 16
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	IDA	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	YEAST|SGD=S000003870|UniProtKB=P03965	Carbamoyl-phosphate synthase arginine-specific large chain	ISS			PTHR11405:SF48	CARBAMOYL-PHOSPHATE SYNTHASE ARGININE-SPECIFIC LARGE CHAIN
P00036	Interleukin signaling pathway	P00973	PKB	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00053	T cell activation	P01332	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00009	Axon guidance mediated by netrin	P00363	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00250	VE-PTP	MACMU|Ensembl=ENSMMUG00000011072|UniProtKB=F7GKG4	Uncharacterized protein	ISS	10557082	PubMed	PTHR19134:SF288	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE BETA
P00010	B cell activation	P00371	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00944	Actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	ISS	11889126	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	PANTR|Ensembl=ENSPTRG00000002995|UniProtKB=H2Q2N8	Regulator of G-protein signaling 10	ISS	8756726	PubMed	PTHR10845:SF182	REGULATOR OF G-PROTEIN SIGNALING 10
P00018	EGF receptor signaling pathway	P00556	PLCgamma	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00054	Toll receptor signaling pathway	P01375	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	ISS	10514528	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00034	Integrin signalling pathway	P00924	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	3449797	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	BOVIN|Ensembl=ENSBTAG00000009702|UniProtKB=F1N775	Uncharacterized protein	IEP	10938134	PubMed	PTHR13140:SF368	MYOSIN-8
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00586	Gq	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	STRPU|Gene=CYIIIA|UniProtKB=P53474	Actin, cytoskeletal 3A	IC	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02746	Heme biosynthesis	P02979	porphobilinogen synthase	CHLTR|EnsemblGenome=CT_633|UniProtKB=O84638	Delta-aminolevulinic acid dehydratase	ISS			PTHR11458:SF0	DELTA-AMINOLEVULINIC ACID DEHYDRATASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	RCA	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01199	Galpha	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12805548	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000012036|UniProtKB=F7ALP1	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IDA	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9441|UniProtKB=P51817	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	SCHMA|EnsemblGenome=Smp_165490|UniProtKB=C1LZY9	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	IC	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00054	Toll receptor signaling pathway	P01368	MKK2	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05730	Endogenous cannabinoid signaling	P05751	Galpha	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00029	Huntington disease	P00778	NMDA receptor	PANTR|Ensembl=ENSPTRG00000004718|UniProtKB=H2Q5I0	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04398	p53 pathway feedback loops 2	G04714	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CHICK|Ensembl=ENSGALG00000028749|UniProtKB=Q5ZMQ2	Actin, cytoplasmic 2	ISS	11889139	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00019	Endothelin signaling pathway	P00589	Akt	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	IGI	98382502	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00760	Gtalpha	DANRE|ZFIN=ZDB-GENE-011128-11|UniProtKB=Q90WX6	Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1	IDA	6264430	PubMed	PTHR10218:SF67	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00236	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	ISS	96320556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00018	EGF receptor signaling pathway	P00552	Ras	CAEBR|Gene=CBG06092|UniProtKB=A8X0X5	Protein CBR-LET-60	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=1196627|UniProtKB=Q9R1C8	5-hydroxytryptamine receptor 6	IDA			PTHR24247:SF114	5-HYDROXYTRYPTAMINE RECEPTOR 6
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	TAS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00004	Alzheimer disease-presenilin pathway	P00111	C99	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P06587	Nicotine pharmacodynamics pathway	P06606	ADCY2	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	RCA	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00019	Endothelin signaling pathway	P00571	Pro ET1-4	RAT|RGD=2532|UniProtKB=P22388	Endothelin-1	ISS	12773307	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P00029	Huntington disease	P00796	Kainate receptor	CHICK|Ensembl=ENSGALG00000006638|UniProtKB=R4GGL9	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00053	T cell activation	P01323	I kappa B	RAT|RGD=3171|UniProtKB=Q63746	NF-kappa-B inhibitor alpha	ISS	10811867	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	DROME|FlyBase=FBgn0001991|UniProtKB=Q24270	Voltage-dependent calcium channel type D subunit alpha-1	IC	91056091	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00053	T cell activation	P01323	I kappa B	PANTR|Ensembl=ENSPTRG00000006265|UniProtKB=H2Q867	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	ISS	14665694	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00053	T cell activation	P01322	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02744	Fructose galactose metabolism	P02960	Galactokinase	CANLF|Ensembl=ENSCAFG00000004914|UniProtKB=Q9GKK4	Galactokinase	NAS	12003984	gi	PTHR10457:SF6	GALACTOKINASE
P04393	Ras Pathway	P04547	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	RAT|RGD=2246|UniProtKB=Q07652	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	11976940	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00036	Interleukin signaling pathway	P00976	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05915	Opioid proenkephalin pathway	P05994	G-protein	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00009	Axon guidance mediated by netrin	P00366	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00236	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00373	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00053	T cell activation	P01309	fos	MONDO|Ensembl=ENSMODG00000005927|UniProtKB=F6WX28	Uncharacterized protein	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00054	Toll receptor signaling pathway	P01369	MKK1	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00012	Cadherin signaling pathway	P00475	Frizzled	PANTR|Ensembl=ENSPTRG00000020122|UniProtKB=H2QVZ0	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF22	FRIZZLED-3
P05916	Opioid prodynorphin pathway	P06002	G-protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	ISS	1482697	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00025	Hedgehog signaling pathway	P00682	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P02741	Flavin biosynthesis	P02938	Pyrimidine reductase	NEUCR|EnsemblGenome=EFNCRG00000008432|UniProtKB=Q7SA75	Riboflavin biosynthesis protein Rib7	ISS			PTHR45196:SF1	2,5-DIAMINO-6-RIBOSYLAMINO-4 3H -PYRIMIDINONE 5'-PHOSPHATE REDUCTASE
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	ISS	10553940	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00048	PI3 kinase pathway	P01202	p85	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00556	PLCgamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00049	Parkinson disease	P01212	p38 MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02738	De novo purine biosynthesis	P02891	GDP kinase	MACMU|Ensembl=ENSMMUG00000003857|UniProtKB=F7HA84	Nucleoside diphosphate kinase	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P00005	Angiogenesis	P00193	SOS-1	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00011	Blood coagulation	P00421	alpha1-antitrypsin	PANTR|Ensembl=ENSPTRG00000023666|UniProtKB=H2R1G9	Uncharacterized protein	ISS	1942629	gi	PTHR11461:SF165	ALPHA-1-ANTITRYPSIN-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00014	Cholesterol biosynthesis	P00497	Anosterol synthase	HUMAN|HGNC=6708|UniProtKB=P48449	Lanosterol synthase	ISS	P38604	SPACC	PTHR11764:SF20	LANOSTEROL SYNTHASE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	NEUCR|EnsemblGenome=EFNCRG00000000159|UniProtKB=F5HH30	Guanine nucleotide-binding protein beta subunit	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000024992|UniProtKB=F6TUR3	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P05731	GABA-B receptor II signaling	P05754	Ggamma	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00048	PI3 kinase pathway	P01181	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	P00558	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IGI	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00049	Parkinson disease	P01219	SAPK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MACMU|Ensembl=ENSMMUG00000002102|UniProtKB=F6WHR2	Uncharacterized protein	ISS	10941822	PubMed	PTHR10489:SF635	C-C CHEMOKINE RECEPTOR TYPE 7
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=7596|UniProtKB=O43795	Unconventional myosin-Ib	IC			PTHR13140:SF277	UNCONVENTIONAL MYOSIN-IB
P00025	Hedgehog signaling pathway	P00691	CBP	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00029	Huntington disease	P00807	Actin	PHANO|EnsemblGenome=SNOG_01139|UniProtKB=H2KNE6	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	HUMAN|HGNC=4583|UniProtKB=Q16478	Glutamate receptor ionotropic, kainate 5	ISS	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00049	Parkinson disease	P01219	SAPK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	DROME|FlyBase=FBgn0001965|UniProtKB=P26675	Protein son of sevenless	ISS	8479536	PubMed	PTHR23113:SF99	PROTEIN SON OF SEVENLESS
P00018	EGF receptor signaling pathway	P00560	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01227	20S proteasome	XENTR|Xenbase=XB-GENE-943786|UniProtKB=Q6P7Z3	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF11	PROTEASOME SUBUNIT ALPHA TYPE-6
P00016	Cytoskeletal regulation by Rho GTPase	P00514	MLCK	PANTR|Ensembl=ENSPTRG00000008081|UniProtKB=H2QB15	Uncharacterized protein	ISS	11157482	PubMed	PTHR45411:SF1	MYOSIN LIGHT CHAIN KINASE 3
P00054	Toll receptor signaling pathway	P01368	MKK2	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	SULSO|EnsemblGenome=SSO0242|UniProtKB=Q980P5	Adenylosuccinate synthetase	IEP	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00059	p53 pathway	G04702	p53	PANTR|Ensembl=ENSPTRG00000015733|UniProtKB=H2QNY5	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00036	Interleukin signaling pathway	P00973	PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00637	MKK4,7	MONDO|Ensembl=ENSMODG00000014960|UniProtKB=F7D0A6	Uncharacterized protein	RCA			PTHR24361:SF387	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	DROME|FlyBase=FBgn0001991|UniProtKB=Q24270	Voltage-dependent calcium channel type D subunit alpha-1	ISS	15737619	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00012	Cadherin signaling pathway	P00470	F-actin	DROME|FlyBase=FBgn0000043|UniProtKB=P02572	Actin-42A	ISS	11889126	PubMed	PTHR11937:SF369	ACTIN-42A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	ISS	188830	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	PANTR|Ensembl=ENSPTRG00000019660|UniProtKB=H2QVB7	Inosine-5'-monophosphate dehydrogenase	ISS			PTHR11911:SF74	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 1
P00006	Apoptosis signaling pathway	P00264	c-IAP1,2	HUMAN|HGNC=591|UniProtKB=Q13489	Baculoviral IAP repeat-containing protein 3	IDA	8552191	PubMed	PTHR10044:SF99	BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 3
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	ECOLI|EcoGene=EG10134|UniProtKB=P0A6F1	Carbamoyl-phosphate synthase small chain	ISS			PTHR11405:SF4	CARBAMOYL-PHOSPHATE SYNTHASE ARGININE-SPECIFIC SMALL CHAIN
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	IDA	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00049	Parkinson disease	P01215	Syntaxin	MOUSE|MGI=MGI=1931027|UniProtKB=Q9ER00	Syntaxin-12	ISS	14570579	PubMed	PTHR19957:SF88	SYNTAXIN-12
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	RCA	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	XENTR|Xenbase=XB-GENE-482228|UniProtKB=F6RYL1	Uncharacterized protein	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00057	Wnt signaling pathway	P01443	Phospholipase C	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	IDA	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=3346|UniProtKB=P10688	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	10934033	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00048	PI3 kinase pathway	P01192	p110	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MOUSE|MGI=MGI=1339711|UniProtKB=Q5SX40	Myosin-1	ISS	89264452	PubMed	PTHR13140:SF484	MYOSIN-1
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT1G53510|UniProtKB=Q9C5C0	Mitogen-activated protein kinase 18	IDA			PTHR24055:SF200	MITOGEN-ACTIVATED PROTEIN KINASE 18-RELATED
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	10477300	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IC	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	RCA	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IPI	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00060	Ubiquitin proteasome pathway	P01491	E2	DANRE|ZFIN=ZDB-GENE-040718-247|UniProtKB=Q6DGE1	Uncharacterized protein	ISS			PTHR43898:SF6	UBIQUITIN-CONJUGATING ENZYME E2 B
P02763	Peptidoglycan biosynthesis	P03090	N-Acetylglucosaminyl transferase	BACSU|EnsemblGenome=BSU13350|UniProtKB=C0SPB9	Uncharacterized glycosyltransferase YkoN	ISS			PTHR43025:SF3	MONOGALACTOSYLDIACYLGLYCEROL SYNTHASE 1, CHLOROPLASTIC
P00053	T cell activation	P01305	Calmodulin	PHYPA|Gene=PHYPADRAFT_210000|UniProtKB=A9S9L5	Predicted protein	ISS			PTHR23050:SF245	AT16150P-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00049	Parkinson disease	P01208	Hsp70	YEAST|SGD=S000005153|UniProtKB=P40150	Heat shock protein SSB2	IDA	12150907	PubMed	PTHR19375:SF256	HSP70 PROTEIN-RELATED
P04398	p53 pathway feedback loops 2	P04651	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	SCHMA|EnsemblGenome=Smp_202970|UniProtKB=G4VLN1	Putative uncharacterized protein Smp_202970	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00045	Notch signaling pathway	P01117	Neuralized	HUMAN|HGNC=16156|UniProtKB=Q9BR09	Neuralized-like protein 2	RCA			PTHR12429:SF8	NEURALIZED-LIKE PROTEIN 2
P00005	Angiogenesis	P00223	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01150	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00010	B cell activation	P00383	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IDA	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00021	FGF signaling pathway	P00638	PLCgamma	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P02746	Heme biosynthesis	P02982	Protoheme IX farnesyl transferase	DROME|FlyBase=FBgn0032222|UniProtKB=Q9VKZ1	CG5037	ISS			PTHR43448:SF2	PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DANRE|ZFIN=ZDB-GENE-000322-1|UniProtKB=Q9I8V1	Actin, alpha 1, skeletal muscle	IEP	11889126	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DANRE|ZFIN=ZDB-GENE-030131-1229|UniProtKB=Q6DHS1	Actin, alpha 2, smooth muscle, aorta	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00049	Parkinson disease	P01212	p38 MAPK	DROME|FlyBase=FBgn0024846|UniProtKB=O61443	Mitogen-activated protein kinase 14B	NAS	10514528	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00025	Hedgehog signaling pathway	P00682	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000009389|UniProtKB=F7HEV7	Uncharacterized protein	ISS	11259487	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00048	PI3 kinase pathway	P01187	IR	RAT|RGD=2917|UniProtKB=P15127	Insulin receptor	IDA	249616	gi	PTHR24416:SF402	INSULIN RECEPTOR
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	HUMAN|HGNC=3824|UniProtKB=Q05932	Folylpolyglutamate synthase, mitochondrial	ISS			PTHR11136:SF5	FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000015972|UniProtKB=H2QPB5	Protocadherin 7	ISS	8120095	PubMed	PTHR43912:SF8	PROTOCADHERIN-7
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	NEUCR|EnsemblGenome=EFNCRG00000001037|UniProtKB=Q7SE08	Phosphoinositide phospholipase C	ISS			PTHR10336:SF82	SUBFAMILY NOT NAMED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04586	ProTRH (Pro Thyrotropin-releasing Hormone)	CANLF|Gene=CGA|UniProtKB=Q9XSW8	Glycoprotein hormones alpha chain	ISS			PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DICPU|Gene=DICPUDRAFT_92985|UniProtKB=F1A084	Putative uncharacterized protein rac1A	ISS	8649368	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	CANLF|Ensembl=ENSCAFG00000012838|UniProtKB=F1PWH1	Uncharacterized protein	ISS	10839363	PubMed	PTHR19957:SF104	SYNTAXIN-6
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	DICDI|dictyBase=DDB_G0277143|UniProtKB=P36408	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04393	Ras Pathway	P04552	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MOUSE|MGI=MGI=1341110|UniProtKB=P97490	Adenylate cyclase type 8	ISS	12890691	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05913	Enkephalin release	P05977	G-Protein (s)	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00021	FGF signaling pathway	P00627	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	20027584	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00018	EGF receptor signaling pathway	P00552	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IPI	14526383	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	RCA	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	3755548	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01092	delta	MOUSE|MGI=MGI=87893|UniProtKB=P02716	Acetylcholine receptor subunit delta	ISS	85203892	PubMed	PTHR18945:SF61	ACETYLCHOLINE RECEPTOR SUBUNIT DELTA
P04397	p53 pathway by glucose deprivation	P04641	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04657	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00628	JNK1-3	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	ANOGA|EnsemblGenome=AGAP009322|UniProtKB=Q7QGG0	AGAP009322-PA	ISS	10908612	PubMed	PTHR21230:SF39	VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	RCA	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00057	Wnt signaling pathway	P01440	Cadherin	CANLF|Ensembl=ENSCAFG00000014229|UniProtKB=F1P8X5	Uncharacterized protein	ISS	8120095	PubMed	PTHR43956:SF3	CADHERIN-23
P04393	Ras Pathway	P04558	p38	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	8920915	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	SCHPO|PomBase=SPAC110.03|UniProtKB=Q01112	Cell division control protein 42 homolog	ISS	4757952	gi	PTHR24072:SF192	CDC42 HOMOLOG
P06959	CCKR signaling map	P07067	AP2M1	HUMAN|HGNC=564|UniProtKB=Q96CW1	AP-2 complex subunit mu	RCA	16079138	PubMed	PTHR10529:SF236	AP-2 COMPLEX SUBUNIT MU
P00029	Huntington disease	P00810	GAPDH	STRCO|EnsemblGenome=CAB38137|UniProtKB=Q9Z518	Glyceraldehyde-3-phosphate dehydrogenase	ISS			PTHR43148:SF2	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE C-RELATED
P02728	Arginine biosynthesis	P02847	N-actetylornithine deacetylase	ARATH|TAIR=AT4G17830|UniProtKB=Q9C5C4	Acetylornithine deacetylase	ISS			PTHR43808:SF3	ACETYLORNITHINE DEACETYLASE
P00006	Apoptosis signaling pathway	P00321	HSP70	CHICK|Ensembl=ENSGALG00000001000|UniProtKB=Q90593	78 kDa glucose-regulated protein	ISS	10934466	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P04393	Ras Pathway	P04558	p38	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	IDA	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04393	Ras Pathway	P04556	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	IDA	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01428	Frizzled	DROME|FlyBase=FBgn0027342|UniProtKB=Q9NBW1	Frizzled-4	IDA	8717036	PubMed	PTHR11309:SF23	FRIZZLED-4
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00916	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PANTR|Ensembl=ENSPTRG00000008771|UniProtKB=H2QCA0	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF484	MYOSIN-1
P00057	Wnt signaling pathway	P01443	Phospholipase C	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00052	TGF-beta signaling pathway	P01288	FKBP12	LEPIN|EnsemblGenome=LA_2550|UniProtKB=Q8F361	Peptidyl-prolyl cis-trans isomerase	TAS			PTHR10516:SF389	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FPR2
P00057	Wnt signaling pathway	P01453	Ebi	MOUSE|MGI=MGI=1336172|UniProtKB=Q9QXE7	F-box-like/WD repeat-containing protein TBL1X	IDA	11389839	PubMed	PTHR22846:SF2	F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN TBL1X
P06959	CCKR signaling map	P07150	beta-catenin	HUMAN|HGNC=2514|UniProtKB=P35222	Catenin beta-1	RCA	18515095	PubMed	PTHR23315:SF53	CATENIN BETA-1
P06212	DPP-SCW signaling pathway	P06266	SOG	DROME|FlyBase=FBgn0003463|UniProtKB=Q24025	Dorsal-ventral patterning protein Sog	IDA	16781701	PubMed	PTHR11339:SF357	DORSAL-VENTRAL PATTERNING PROTEIN SOG
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00034	Integrin signalling pathway	P00906	Rap1	TAKRU|Ensembl=ENSTRUG00000006464|UniProtKB=H2STT5	Uncharacterized protein	ISS	1904317	PubMed	PTHR24070:SF382	RAS-RELATED PROTEIN RAP-1B
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	RAT|RGD=2026|UniProtKB=P68035	Actin, alpha cardiac muscle 1	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	ANOGA|EnsemblGenome=AGAP005913|UniProtKB=Q7Q6D2	AGAP005913-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=12780|UniProtKB=P09544	Protein Wnt-2	IDA	11266476	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00049	Parkinson disease	P01230	Src kinase	PANTR|Ensembl=ENSPTRG00000020263|UniProtKB=H2R453	Tyrosine-protein kinase	ISS	1371009	PubMed	PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P05915	Opioid proenkephalin pathway	P05994	G-protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00007	Axon guidance mediated by semaphorins	P00341	Rho	BOVIN|Ensembl=ENSBTAG00000004279|UniProtKB=P61585	Transforming protein RhoA	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	RAT|RGD=3425|UniProtKB=P97887	Presenilin-1	TAS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MONDO|Ensembl=ENSMODG00000008900|UniProtKB=F7B4C1	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00021	FGF signaling pathway	P00624	14-3-3	RAT|RGD=3979|UniProtKB=P68255	14-3-3 protein theta	ISS	10407019	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P05916	Opioid prodynorphin pathway	P06000	vasopressin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CAEBR|Gene=CBG05896|UniProtKB=A8X1E0	Phosphoinositide phospholipase C	ISS			PTHR10336:SF147	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-2
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	MACMU|Ensembl=ENSMMUG00000010122|UniProtKB=F7HF84	Casein kinase I isoform epsilon	ISS	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02926	Aspartate carbamoyltransferase	BACSU|EnsemblGenome=BSU15490|UniProtKB=P05654	Aspartate carbamoyltransferase	ISS			PTHR11405:SF16	ASPARTATE CARBAMOYLTRANSFERASE, CHLOROPLASTIC
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05918	p38 MAPK pathway	P06015	p38gamma	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	8920915	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	HUMAN|HGNC=9509|UniProtKB=P49810	Presenilin-2	TAS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	STRPU|EnsemblGenome=SPU_026078|UniProtKB=W4ZD41	Uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF277	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00219	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04398	p53 pathway feedback loops 2	P04657	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	21071228	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00019	Endothelin signaling pathway	P00587	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00022	General transcription by RNA polymerase I	P00650	TAF-IB	CHICK|Ensembl=ENSGALG00000003498|UniProtKB=Q5ZMS1	Transcription initiation factor TFIID subunit 8	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00018	EGF receptor signaling pathway	P00547	PP2A	CANLF|Ensembl=ENSCAFG00000006453|UniProtKB=F6X958	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P06213	DPP signaling pathway	P06278	LACK	DROME|FlyBase=FBgn0029006|UniProtKB=Q9V853	E3 ubiquitin-protein ligase Smurf1	IEA	11252892	PubMed	PTHR11254:SF395	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00006	Apoptosis signaling pathway	P00269	MAPK	CHLRE|EnsemblGenome=CHLREDRAFT_193901|UniProtKB=Q9FXT7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00309	Smac/Diablo	RAT|RGD=2321120|UniProtKB=D4A7Z5	Protein LOC100360940	ISS	10929712	PubMed	PTHR32247:SF3	DIABLO HOMOLOG, MITOCHONDRIAL
P00021	FGF signaling pathway	P00631	Grb2	MACMU|Ensembl=ENSMMUG00000005327|UniProtKB=F7GJG7	GRB2-related adapter protein	ISS	51702266	gi	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P02787	Vitamin B6 metabolism	P03242	Threonine synthase	SCHPO|PomBase=SPAC9E9.06c|UniProtKB=Q42598	Threonine synthase	ISS	9501991	PubMed	PTHR42690:SF1	THREONINE SYNTHASE-LIKE 2
P00005	Angiogenesis	P00249	PAK	MOUSE|MGI=MGI=1339975|UniProtKB=O88643	Serine/threonine-protein kinase PAK 1	ISS	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01087	CAT	CAEBR|Gene=CBG08305|UniProtKB=A8X694	Protein CBR-CHA-1	ISS	92155737	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MONDO|Ensembl=ENSMODG00000012546|UniProtKB=F6PM16	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00004	Alzheimer disease-presenilin pathway	P00162	Pro-BACE-1	MACMU|Ensembl=ENSMMUG00000007785|UniProtKB=F7CQI1	Beta-secretase 1 isoform A preproprotein	ISS	10956649	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IGI	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00036	Interleukin signaling pathway	P00965	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IC	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P06664	Gonadotropin-releasing hormone receptor pathway	P06720	OCT-1	MOUSE|MGI=MGI=101898|UniProtKB=P25425	POU domain, class 2, transcription factor 1	RCA			PTHR11636:SF47	POU DOMAIN, CLASS 2, TRANSCRIPTION FACTOR 1
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CAEEL|WormBase=WBGene00003186|UniProtKB=Q10664	Dual specificity mitogen-activated protein kinase kinase mek-2	IGI	12024031	PubMed	PTHR24361:SF629	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1
P00029	Huntington disease	G01535	PIG3	PANTR|Ensembl=ENSPTRG00000008374|UniProtKB=H2QBJ9	Uncharacterized protein	ISS	12932731	PubMed	PTHR44054:SF2	SYNAPTIC VESICLE MEMBRANE PROTEIN VAT-1 HOMOLOG-LIKE
P00018	EGF receptor signaling pathway	P00548	RKIP	ARATH|TAIR=AT1G65480|UniProtKB=Q9SXZ2	Protein FLOWERING LOCUS T	ISS			PTHR11362:SF9	PROTEIN FLOWERING LOCUS T-RELATED
P00021	FGF signaling pathway	P00643	Raf-1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=109485|UniProtKB=Q9WUD6	Protein Wnt-8b	IDA	11266476	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00927	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	IDA	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00012	Cadherin signaling pathway	P00477	GSK3beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	P00546	GAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	88318957	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	DANRE|ZFIN=ZDB-GENE-030131-9435|UniProtKB=F1R8S3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	MACMU|Ensembl=ENSMMUG00000018136|UniProtKB=F7DHW8	G protein-activated inward rectifier potassium channel 2	ISS	2433589	PubMed	PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P00018	EGF receptor signaling pathway	P00545	JNK1-3	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Gene=GRIK4|UniProtKB=Q5IS46	Glutamate receptor ionotropic, kainate 4	ISS	12871085	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00012	Cadherin signaling pathway	P00472	Tyrosine phosphatases	MOUSE|MGI=MGI=97805|UniProtKB=P35821	Tyrosine-protein phosphatase non-receptor type 1	ISS			PTHR19134:SF239	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008422|UniProtKB=F6VUT7	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000017612|UniProtKB=C7G3N0	Glutamate receptor, metabotropic 6	ISS	12351712	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00060	Ubiquitin proteasome pathway	P01491	E2	HUMAN|HGNC=21647|UniProtKB=Q9Y2X8	Ubiquitin-conjugating enzyme E2 D4	ISS			PTHR24068:SF24	UBIQUITIN-CONJUGATING ENZYME E2 D4
P00056	VEGF signaling pathway	P01417	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANAL|CGD=CAL0068551|UniProtKB=Q5AAR9	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00057	Wnt signaling pathway	P01451	Galpha	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00036	Interleukin signaling pathway	P00977	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00022	General transcription by RNA polymerase I	P00651	TAF-IA	PANTR|Ensembl=ENSPTRG00000002007|UniProtKB=H2Q165	TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa	ISS	600075	OMIM	PTHR32122:SF1	TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00628	JNK1-3	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00012	Cadherin signaling pathway	P00464	Fyn	BOVIN|Ensembl=ENSBTAG00000011851|UniProtKB=A0JNB0	Tyrosine-protein kinase Fyn	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00029	Huntington disease	P00807	Actin	DROME|FlyBase=FBgn0011743|UniProtKB=P45891	Actin-like protein 53D	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05915	Opioid proenkephalin pathway	P05994	G-protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	RAT|RGD=62030|UniProtKB=P02564	Myosin-7	ISS	10938134	PubMed	PTHR13140:SF344	MYOSIN-7
P00059	p53 pathway	P04633	P110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00639	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	7798194	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00005	Angiogenesis	P00190	RasGAP	HUMAN|HGNC=9871|UniProtKB=P20936	Ras GTPase-activating protein 1	IDA	8270251	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00009	Axon guidance mediated by netrin	P00363	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00007	Axon guidance mediated by semaphorins	P00340	Rac	MACMU|Ensembl=ENSMMUG00000021075|UniProtKB=F7GY91	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001749|UniProtKB=H2Q0Q4	Uncharacterized protein	ISS	14507926	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00048	PI3 kinase pathway	P01185	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CHICK|Ensembl=ENSGALG00000014620|UniProtKB=F1N8P3	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00562	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00047	PDGF signaling pathway	P01167	Ets	CANLF|Ensembl=ENSCAFG00000001227|UniProtKB=E2RGK1	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF182	SAM POINTED DOMAIN-CONTAINING ETS TRANSCRIPTION FACTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00049	Parkinson disease	P01227	20S proteasome	DANRE|ZFIN=ZDB-GENE-040426-1932|UniProtKB=Q7ZV77	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF13	PROTEASOME SUBUNIT ALPHA TYPE-4
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04496	Mdm2	MOUSE|MGI=MGI=96952|UniProtKB=P23804	E3 ubiquitin-protein ligase Mdm2	IGI	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00047	PDGF signaling pathway	P01155	Jak	HUMAN|HGNC=6192|UniProtKB=O60674	Tyrosine-protein kinase JAK2	ISS	22482294	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	BRAFL|Gene=BRAFLDRAFT_122664|UniProtKB=C3ZIB9	Putative uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00054	Toll receptor signaling pathway	P01354	NFkappaB	RAT|RGD=1307189|UniProtKB=Q5U2Z4	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	ISS	20151924	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	MONDO|Ensembl=ENSMODG00000011192|UniProtKB=F6SRK5	Uncharacterized protein	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00048	PI3 kinase pathway	P01193	IRS	MACMU|Ensembl=ENSMMUG00000019467|UniProtKB=F6SUL3	Uncharacterized protein	ISS	5031805	gi	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00053	T cell activation	P01322	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P05915	Opioid proenkephalin pathway	P05994	G-protein	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P06959	CCKR signaling map	P07204	CD38	HUMAN|HGNC=1667|UniProtKB=P28907	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	RCA	12807891	PubMed	PTHR10912:SF5	ADP-RIBOSYL CYCLASE/CYCLIC ADP-RIBOSE HYDROLASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MOUSE|MGI=MGI=95823|UniProtKB=Q03391	Glutamate receptor ionotropic, NMDA 2D	IC	11319238	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=1307591|UniProtKB=D3ZM08	Protein Pcdhb14	ISS	8120095	PubMed	PTHR24028:SF139	PROTOCADHERIN BETA-14
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	XENTR|Xenbase=XB-GENE-866811|UniProtKB=F7EI91	Uncharacterized protein (Fragment)	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00049	Parkinson disease	P01236	Casein kinase II	ARATH|TAIR=AT5G47080|UniProtKB=P40228	Casein kinase II subunit beta	IDA	10617630	PubMed	PTHR11740:SF15	CASEIN KINASE II SUBUNIT BETA-RELATED
P00010	B cell activation	P00384	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IDA	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00049	Parkinson disease	P01227	20S proteasome	RAT|RGD=621092|UniProtKB=P18421	Proteasome subunit beta type-1	ISS	12859888	PubMed	PTHR11599:SF59	PROTEASOME SUBUNIT BETA TYPE-1
P00057	Wnt signaling pathway	P01431	LRP5/6	CANLF|Ensembl=ENSCAFG00000010871|UniProtKB=F1PXA0	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	PANTR|Ensembl=ENSPTRG00000020490|UniProtKB=H2R2C6	Frizzled homolog 6	ISS	11212302	PubMed	PTHR11309:SF75	FRIZZLED-6
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00023	General transcription regulation	P00658	TBP-associated factors	DROME|FlyBase=FBgn0002842|UniProtKB=Q9VP40	Spermatocyte arrest	ISS	604904	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	RCA	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02779	Thiamin biosynthesis	P03175	1-Deoxyxylulose-5-phosphate synthase	PSEAE|EnsemblGenome=PA4044|UniProtKB=Q9KGU7	1-deoxy-D-xylulose-5-phosphate synthase	ISS			PTHR43322:SF6	1-DEOXY-D-XYLULOSE-5-PHOSPHATE SYNTHASE
P00059	p53 pathway	P04630	PP2A	TAKRU|Ensembl=ENSTRUG00000011169|UniProtKB=H2TU36	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00925	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P06587	Nicotine pharmacodynamics pathway	P06608	DDC	MOUSE|MGI=MGI=94876|UniProtKB=O88533	Aromatic-L-amino-acid decarboxylase	TAS	90339966	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	TAKRU|Ensembl=ENSTRUG00000011297|UniProtKB=H2TV18	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT1G73670|UniProtKB=Q9C9U4	Mitogen-activated protein kinase 15	ISS	12787066	PubMed	PTHR24055:SF246	MITOGEN-ACTIVATED PROTEIN KINASE 15-RELATED
P05731	GABA-B receptor II signaling	P05756	GABA-B receptor	MACMU|Ensembl=ENSMMUG00000021483|UniProtKB=F7CCU5	Uncharacterized protein	ISS	9872315	PubMed	PTHR10519:SF42	GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00023	General transcription regulation	P00667	TFIIFbeta	YEAST|SGD=S000003237|UniProtKB=P41896	Transcription initiation factor IIF subunit beta	ISS			PTHR10445:SF0	GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2
P00021	FGF signaling pathway	P00630	RKIP	PANTR|Ensembl=ENSPTRG00000005512|UniProtKB=H2Q6Z4	Phosphatidylethanolamine binding protein 1	ISS	92031654	PubMed	PTHR11362:SF28	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT3G14720|UniProtKB=Q9LUC3	Mitogen-activated protein kinase 19	IDA			PTHR24055:SF200	MITOGEN-ACTIVATED PROTEIN KINASE 18-RELATED
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IGI	98189216	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	RCA			PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00059	p53 pathway	G01579	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CAEBR|Gene=CBG02161|UniProtKB=A8WS32	Protein CBG02161	ISS	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	MONDO|Ensembl=ENSMODG00000023104|UniProtKB=F7AZP2	Uncharacterized protein	ISS	15032587	PubMed	PTHR44282:SF3	SUPPRESSOR OF CYTOKINE SIGNALING 5
P00019	Endothelin signaling pathway	P00566	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=1310389|UniProtKB=D3ZTF6	Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Predicted), isoform CRA_a	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00951	Jnk	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00036	Interleukin signaling pathway	P00996	STAT	MOUSE|MGI=MGI=103038|UniProtKB=P42227	Signal transducer and activator of transcription 3	IC	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06809	FSHbeta	MOUSE|MGI=MGI=95582|UniProtKB=Q60687	Follitropin subunit beta	RCA			PTHR11515:SF17	FOLLITROPIN SUBUNIT BETA
P00004	Alzheimer disease-presenilin pathway	P00110	Ire-1 N-terminal fragment	SCHPO|PomBase=SPAC167.01|UniProtKB=O94537	Serine/threonine-protein kinase ppk4	IDA	10619423	PubMed	PTHR13954:SF6	INOSITOL-REQUIRING ENZYME-1
P00005	Angiogenesis	P00207	Crk	HUMAN|HGNC=2363|UniProtKB=P46109	Crk-like protein	ISS	8649368	PubMed	PTHR19969:SF9	CRK-LIKE PROTEIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2048|UniProtKB=P25099	Adenosine receptor A1	ISS	12515326	PubMed	PTHR24246:SF1	ADENOSINE RECEPTOR A1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00034	Integrin signalling pathway	P00951	Jnk	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00034	Integrin signalling pathway	P00941	Integrin alpha	PANTR|Ensembl=ENSPTRG00000009277|UniProtKB=H2QD72	Uncharacterized protein	ISS	386753	gi	PTHR23220:SF73	INTEGRIN ALPHA-IIB
P00059	p53 pathway	P04633	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00059	p53 pathway	G01575	GADD45	HUMAN|HGNC=4095|UniProtKB=P24522	Growth arrest and DNA damage-inducible protein GADD45 alpha	IGI	9827804	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P00029	Huntington disease	P00790	beta-Tubulin	DROME|FlyBase=FBgn0003887|UniProtKB=Q24560	Tubulin beta-1 chain	TAS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00046	Oxidative stress response	P01137	MNK1/2	MACMU|Ensembl=ENSMMUG00000020162|UniProtKB=F6TJV6	Uncharacterized protein	ISS	11575158	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00059	p53 pathway	P04611	P300	BOVIN|Ensembl=ENSBTAG00000016198|UniProtKB=E1B8D6	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DICDI|dictyBase=DDB_G0289489|UniProtKB=P07828	Actin-18	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00047	PDGF signaling pathway	P01167	Ets	RAT|RGD=621108|UniProtKB=A0A0G2JWE9	Potassium voltage-gated channel subfamily H member 2	ISS	15298723	PubMed	PTHR11849:SF216	TRANSCRIPTIONAL REGULATOR ERG
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00053	T cell activation	P01306	Ras	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	IDA	22097630	PubMed	PTHR24070:SF189	GTPASE NRAS
P00036	Interleukin signaling pathway	P00977	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IC	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	RAT|RGD=621346|UniProtKB=Q2IBD1	Protein Wnt	TAS	11266476	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00057	Wnt signaling pathway	P01465	Ggamma	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00005	Angiogenesis	P00219	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00059	p53 pathway	P04609	PI3K	DROME|FlyBase=FBgn0015278|UniProtKB=Q7K3H0	LD28067p	ISS	8662856	PubMed	PTHR10048:SF64	LD28067P
P00021	FGF signaling pathway	P00640	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	G01540	BDNF	ORNAN|Ensembl=ENSOANG00000013030|UniProtKB=O02795	Brain-derived neurotrophic factor (Fragment)	ISS	11408619	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00025	Hedgehog signaling pathway	P00691	CBP	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00023	General transcription regulation	P00664	TFIIH complex	MONDO|Ensembl=ENSMODG00000006540|UniProtKB=F7BVJ4	Uncharacterized protein	ISS			PTHR12856:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 1
P05731	GABA-B receptor II signaling	P05754	Ggamma	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00047	PDGF signaling pathway	P01153	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P02723	Adenine and hypoxanthine salvage pathway	P02811	Adenosine deaminase	MYCTU|EnsemblGenome=Rv3313c|UniProtKB=P63907	Adenosine deaminase	ISS			PTHR11409:SF43	ADENOSINE DEAMINASE
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	11256888	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00005	Angiogenesis	P00240	FRS-2	CANLF|Ensembl=ENSCAFG00000000431|UniProtKB=E2QSI0	Uncharacterized protein	ISS	10464310	PubMed	PTHR21258:SF40	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	RAT|RGD=620577|UniProtKB=Q62636	Ras-related protein Rap-1b	IDA	8576107	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-030131-7595|UniProtKB=Q6PBR4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00059	p53 pathway	P04635	Sumo-1 ligase	MONDO|Ensembl=ENSMODG00000024906|UniProtKB=F6WCZ7	Small ubiquitin-related modifier	ISS			PTHR10562:SF55	SUBFAMILY NOT NAMED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	RCA	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01001	KA4	CHICK|Ensembl=ENSGALG00000006638|UniProtKB=R4GGL9	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00034	Integrin signalling pathway	P00924	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IPI	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05918	p38 MAPK pathway	P06021	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	15470041	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00006	Apoptosis signaling pathway	P00305	Caspase 3	HUMAN|HGNC=1504|UniProtKB=P42574	Caspase-3	IDA	11675509	PubMed	PTHR10454:SF198	CASPASE-3
P00060	Ubiquitin proteasome pathway	P01491	E2	TAKRU|Ensembl=ENSTRUG00000005995|UniProtKB=H2SQA0	Uncharacterized protein	ISS			PTHR24067:SF172	UBIQUITIN-CONJUGATING ENZYME E2G 2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P06587	Nicotine pharmacodynamics pathway	P06596	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	7689150	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00053	T cell activation	P01312	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04393	Ras Pathway	P04553	PAK	MONDO|Ensembl=ENSMODG00000005255|UniProtKB=F7G800	Uncharacterized protein	ISS	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00054	Toll receptor signaling pathway	P01364	TPL2	RAT|RGD=620969|UniProtKB=Q63562	Mitogen-activated protein kinase kinase kinase 8	IDA	99133929	PubMed	PTHR24361:SF94	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 8
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	HUMAN|HGNC=4241|UniProtKB=Q06210	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1	ISS			PTHR10937:SF2	GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE  ISOMERIZING  1
P00029	Huntington disease	P00790	beta-Tubulin	DANRE|ZFIN=ZDB-GENE-040426-2879|UniProtKB=Q6IQJ2	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00019	Endothelin signaling pathway	P00590	IP3 R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00633	Ras	CHICK|Ensembl=ENSGALG00000014033|UniProtKB=E1BTS2	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00049	Parkinson disease	P01238	14-3-3	MOUSE|MGI=MGI=1891917|UniProtKB=Q9CQV8	14-3-3 protein beta/alpha	ISS	10407019	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00012	Cadherin signaling pathway	P00466	EGFR	HUMAN|HGNC=3236|UniProtKB=P00533	Epidermal growth factor receptor	ISS	90258888	PubMed	PTHR24416:SF91	EPIDERMAL GROWTH FACTOR RECEPTOR
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MOUSE|MGI=MGI=95777|UniProtKB=Q6R0H7	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas	ISS	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	XENTR|Xenbase=XB-GENE-482228|UniProtKB=F6RYL1	Uncharacterized protein	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00014	Cholesterol biosynthesis	P00490	Dimethylallyl trans-transferase	PANTR|Ensembl=ENSPTRG00000002374|UniProtKB=H2Q1R4	Uncharacterized protein	ISS			PTHR12001:SF47	DECAPRENYL-DIPHOSPHATE SYNTHASE SUBUNIT 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	RAT|RGD=2034|UniProtKB=P26770	Adenylate cyclase type 4	IDA	2491850	PubMed	PTHR11920:SF286	ADENYLATE CYCLASE TYPE 4
P02738	De novo purine biosynthesis	P02891	GDP kinase	LEIMA|EnsemblGenome=LmjF.32.2950|UniProtKB=Q9U1E1	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00056	VEGF signaling pathway	P01423	p38MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02746	Heme biosynthesis	P02983	Hydroxymethylbilane synthase	DROME|FlyBase=FBgn0010786|UniProtKB=Q9W0G4	FI03834p	ISS			PTHR11557:SF0	PORPHOBILINOGEN DEAMINASE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	CHICK|Ensembl=ENSGALG00000001172|UniProtKB=P19439	Probable glutamate receptor	ISS	12778120	PubMed	PTHR18966:SF282	GLUTAMATE RECEPTOR-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CHICK|Ensembl=ENSGALG00000019382|UniProtKB=E1BWK1	Uncharacterized protein	ISS	11431030	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	PANTR|Ensembl=ENSPTRG00000007605|UniProtKB=H2QAA6	Nucleoside diphosphate kinase	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	11313908	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04393	Ras Pathway	P04570	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00020	FAS signaling pathway	P00612	Fas	RAT|RGD=619831|UniProtKB=Q63199	Tumor necrosis factor receptor superfamily member 6	TAS	14585074	PubMed	PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01471	alpha-catenin	CHICK|Gene=CTNNA2|UniProtKB=P30997	Catenin alpha-2	IDA	1768802	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00057	Wnt signaling pathway	P01452	NFAT	MACMU|Ensembl=ENSMMUG00000003370|UniProtKB=F7E8G2	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00025	Hedgehog signaling pathway	P00683	Slimb	MOUSE|MGI=MGI=2144023|UniProtKB=Q5SRY7	F-box/WD repeat-containing protein 11	ISS	12628165	PubMed	PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01142	p90RSK	MOUSE|MGI=MGI=1270849|UniProtKB=Q8BSK8	Ribosomal protein S6 kinase beta-1	ISS	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00006	Apoptosis signaling pathway	P00302	ATF	BOVIN|Ensembl=ENSBTAG00000002295|UniProtKB=F1N177	Uncharacterized protein	ISS	10664585	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	HUMAN|HGNC=14656|UniProtKB=Q8TD84	Down syndrome cell adhesion molecule-like protein 1	ISS			PTHR44107:SF3	DOWN SYNDROME CELL ADHESION MOLECULE-LIKE PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	MOUSE|MGI=MGI=109284|UniProtKB=Q61144	Presenilin-2	TAS	12885769	PubMed	PTHR10202:SF13	PRESENILIN-2
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00948	Rho	DROME|FlyBase=FBgn0014020|UniProtKB=P48148	Ras-like GTP-binding protein Rho1	IGI	11973360	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	BOVIN|Ensembl=ENSBTAG00000020887|UniProtKB=F1MP22	Uncharacterized protein	ISS	8386525	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	RAT|RGD=621060|UniProtKB=O88777	Presenilin-2	IDA	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00053	T cell activation	P01312	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05916	Opioid prodynorphin pathway	P06002	G-protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00011	Blood coagulation	P00406	Fibrinogen	RAT|RGD=2603|UniProtKB=P06399	Fibrinogen alpha chain	ISS	1706800	gi	PTHR19143:SF232	FIBRINOGEN ALPHA CHAIN
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00034	Integrin signalling pathway	P00936	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	IPI	14505573	PubMed	PTHR10048:SF14	PI-3 KINASE
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	DANRE|ZFIN=ZDB-GENE-051202-1|UniProtKB=E7F101	Uncharacterized protein	ISS	11319238	PubMed	PTHR44391:SF2	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05917	Opioid proopiomelanocortin pathway	P06006	beta-Endorphin	MACMU|Ensembl=ENSMMUG00000016463|UniProtKB=F7GBI0	Uncharacterized protein	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00057	Wnt signaling pathway	P01444	Wnt	XENTR|Xenbase=XB-GENE-479567|UniProtKB=A4ZGP0	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P00038	JAK/STAT signaling pathway	P01034	Jak	CANLF|Ensembl=ENSCAFG00000002102|UniProtKB=E2RPW6	Tyrosine-protein kinase	ISS	22482294	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P04398	p53 pathway feedback loops 2	P04661	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	7565716	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P06664	Gonadotropin-releasing hormone receptor pathway	P06769	Gbeta	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	RCA	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00006	Apoptosis signaling pathway	P00297	NFkappaB	MOUSE|MGI=MGI=103289|UniProtKB=Q04863	Transcription factor RelB	ISS	12505990	PubMed	PTHR24169:SF18	TRANSCRIPTION FACTOR RELB
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	HUMAN|HGNC=23720|UniProtKB=Q70SY1	Cyclic AMP-responsive element-binding protein 3-like protein 2	ISS	123810	OMIM	PTHR22952:SF96	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 2
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	DROME|FlyBase=FBgn0011300|UniProtKB=A1Z7L8	Receptor protein serine/threonine kinase	TAS	9395284	PubMed	PTHR23255:SF71	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IDA	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00014	Cholesterol biosynthesis	P00491	Hydroxymethyl glutaryl CoA reductase	HUMAN|HGNC=5006|UniProtKB=P04035	3-hydroxy-3-methylglutaryl-coenzyme A reductase	ISS	P09610	SPACC	PTHR10572:SF2	3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE
P00057	Wnt signaling pathway	P01438	PP2A	MOUSE|MGI=MGI=1321161|UniProtKB=P62715	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=2136740|UniProtKB=Q91XZ4	Protein Pcdhb6	IDA	8120095	PubMed	PTHR24028:SF100	MCG141292-RELATED
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	BOVIN|Ensembl=ENSBTAG00000007909|UniProtKB=F1MPE9	Uncharacterized protein	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	TAS	7565716	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00059	p53 pathway	G04702	p53	DANRE|ZFIN=ZDB-GENE-030819-1|UniProtKB=E9QG65	Uncharacterized protein	TAS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00036	Interleukin signaling pathway	P00990	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01451	Galpha	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	XENTR|Ensembl=ENSXETG00000021375|UniProtKB=F6T423	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PHYPA|Gene=PHYPADRAFT_107830|UniProtKB=A9TBG2	Actin 7	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02748	Isoleucine biosynthesis	P02994	Branched chain amino acid aminotransferase	SYNY3|EnsemblGenome=BAA10792|UniProtKB=P54691	Probable branched-chain-amino-acid aminotransferase	ISS			PTHR42743:SF4	SUBFAMILY NOT NAMED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	DROME|FlyBase=FBgn0283499|UniProtKB=P09208	Insulin-like receptor	ISS	6754360	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00010	B cell activation	P00390	Blk	RAT|RGD=1308859|UniProtKB=Q4KM97	Tyrosine-protein kinase	ISS	9013950	PubMed	PTHR24418:SF181	TYROSINE-PROTEIN KINASE BLK
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00049	Parkinson disease	P01211	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	IDA	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05915	Opioid proenkephalin pathway	P05994	G-protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05730	Endogenous cannabinoid signaling	P05743	CB1	CANLF|Ensembl=ENSCAFG00000003085|UniProtKB=F1Q345	Uncharacterized protein	ISS	9888857	PubMed	PTHR22750:SF47	CANNABINOID RECEPTOR 1
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04375	5HT3 type receptor mediated signaling pathway	P04425	K+ channel	MACMU|Ensembl=ENSMMUG00000005826|UniProtKB=F6VE51	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00056	VEGF signaling pathway	P01419	Ets	RAT|RGD=2583|UniProtKB=P41156	Protein C-ets-1	ISS	9157999	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01402	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	RCA			PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000014828|UniProtKB=F1N1E0	Uncharacterized protein	ISS	11976940	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00046	Oxidative stress response	P01134	cPLA2	MONDO|Ensembl=ENSMODG00000011791|UniProtKB=F7CBU9	Phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000025240|UniProtKB=F7A7I3	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00046	Oxidative stress response	P01132	c-jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04494	TSC2	HUMAN|HGNC=12363|UniProtKB=P49815	Tuberin	ISS	12150915	PubMed	PTHR10063:SF0	TUBERIN
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	USTMA|Gene=UMAG_11232|UniProtKB=A0A0D1DMT3	Chromosome 22, whole genome shotgun sequence	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00036	Interleukin signaling pathway	P00977	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P05915	Opioid proenkephalin pathway	P05994	G-protein	CANLF|Ensembl=ENSCAFG00000015662|UniProtKB=E2RHY4	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04393	Ras Pathway	P04557	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IDA	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00089	Pen-2	DROME|FlyBase=FBgn0053198|UniProtKB=Q86BE9	Gamma-secretase subunit pen-2	IDA	12110170	PubMed	PTHR16318:SF0	GAMMA-SECRETASE SUBUNIT PEN-2
P02779	Thiamin biosynthesis	P03175	1-Deoxyxylulose-5-phosphate synthase	MYCTU|EnsemblGenome=Rv2682c|UniProtKB=P9WNS3	1-deoxy-D-xylulose-5-phosphate synthase	ISS			PTHR43322:SF6	1-DEOXY-D-XYLULOSE-5-PHOSPHATE SYNTHASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	HUMAN|HGNC=3084|UniProtKB=O14640	Segment polarity protein dishevelled homolog DVL-1	TAS	11212302	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04633	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	RAT|RGD=2746|UniProtKB=P31424	Metabotropic glutamate receptor 5	ISS	8314195	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00049	Parkinson disease	P01236	Casein kinase II	SCHPO|PomBase=SPAC23C11.11|UniProtKB=P40231	Casein kinase II subunit alpha	IDA	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	MONDO|Ensembl=ENSMODG00000012761|UniProtKB=F6SJA3	Tyrosine-protein kinase receptor (Fragment)	ISS	11182407	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00036	Interleukin signaling pathway	P00973	PKB	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00047	PDGF signaling pathway	P01171	PLCgamma	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	CANLF|Ensembl=ENSCAFG00000019546|UniProtKB=F6X571	Uncharacterized protein	ISS	11313498	gi	PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P00034	Integrin signalling pathway	P00927	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MOUSE|MGI=MGI=1309999|UniProtKB=Q922R0	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00790	beta-Tubulin	STRPU|EnsemblGenome=SPU_013273|UniProtKB=W4YBZ7	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00006	Apoptosis signaling pathway	P00274	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01174	Rho	CANLF|Ensembl=ENSCAFG00000010224|UniProtKB=F1PUX3	Uncharacterized protein	ISS			PTHR14166:SF6	SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 2-RELATED
P00057	Wnt signaling pathway	P01444	Wnt	MACMU|Ensembl=ENSMMUG00000015709|UniProtKB=F6SLX4	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00059	p53 pathway	P04633	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PANTR|Ensembl=ENSPTRG00000002894|UniProtKB=H2Q2H7	ARP1 actin-related protein 1 homolog A, centractin alpha	ISS	14684598	PubMed	PTHR11937:SF46	ALPHA-CENTRACTIN
P00029	Huntington disease	P00811	Arp2/3 complex	CANLF|Ensembl=ENSCAFG00000015094|UniProtKB=F1PT97	Uncharacterized protein	ISS	12963527	gi	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00046	Oxidative stress response	P01138	MKK4	MOUSE|MGI=MGI=1346875|UniProtKB=O08648	Mitogen-activated protein kinase kinase kinase 4	TAS	97236778	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00012	Cadherin signaling pathway	P00470	F-actin	PANTR|Ensembl=ENSPTRG00000009762|UniProtKB=H2QE24	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00053	T cell activation	P01300	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00576	Pre-pro ET1-4	MACMU|Ensembl=ENSMMUG00000016214|UniProtKB=F7GJV6	Uncharacterized protein	ISS	12516960	PubMed	PTHR13874:SF9	ENDOTHELIN-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CANLF|Ensembl=ENSCAFG00000015708|UniProtKB=F2Z4N0	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00036	Interleukin signaling pathway	P00990	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IDA	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	RAT|RGD=2352|UniProtKB=P25110	Acetylcholine receptor subunit delta	IC	85203892	PubMed	PTHR18945:SF61	ACETYLCHOLINE RECEPTOR SUBUNIT DELTA
P05914	Nicotine degradation	P05984	CYP2A6	HUMAN|HGNC=2611|UniProtKB=P20853	Cytochrome P450 2A7	TAS			PTHR24300:SF293	CYTOCHROME P450 2A6-RELATED
P00056	VEGF signaling pathway	P01417	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	XENTR|Xenbase=XB-GENE-992519|UniProtKB=F6VS22	Uncharacterized protein	ISS	11861492	PubMed	PTHR43893:SF8	D 1B  DOPAMINE RECEPTOR
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	RAT|RGD=61801|UniProtKB=P30994	5-hydroxytryptamine receptor 2B	ISS	11859080	PubMed	PTHR24247:SF31	5-HYDROXYTRYPTAMINE RECEPTOR 2B
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00899	IRS 1-4	HUMAN|HGNC=6126|UniProtKB=Q9Y4H2	Insulin receptor substrate 2	ISS	5031805	gi	PTHR10614:SF7	INSULIN RECEPTOR SUBSTRATE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01307	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00036	Interleukin signaling pathway	P00994	FKHRL1	BOVIN|Ensembl=ENSBTAG00000011234|UniProtKB=F1N4K5	Uncharacterized protein	ISS	12884295	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	3755548	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00048	PI3 kinase pathway	P01192	p110	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	RAT|RGD=1304786|UniProtKB=D4AEG0	Protein Rbpjl	ISS	12681948	PubMed	PTHR10665:SF2	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS-LIKE PROTEIN
P00036	Interleukin signaling pathway	P00964	p90RSK	CHICK|Ensembl=ENSGALG00000016406|UniProtKB=F1NLJ3	Uncharacterized protein	ISS	6755374	gi	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00012	Cadherin signaling pathway	P00475	Frizzled	HUMAN|HGNC=4040|UniProtKB=Q14332	Frizzled-2	IDA	8717036	PubMed	PTHR11309:SF34	FRIZZLED-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	CAEEL|WormBase=WBGene00015754|UniProtKB=P34335	Probable phosphorylase b kinase regulatory subunit alpha	IDA	10487978	PubMed	PTHR10749:SF7	PHOSPHORYLASE B KINASE REGULATORY SUBUNIT ALPHA-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	IGI	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00047	PDGF signaling pathway	P01167	Ets	XENTR|Xenbase=XB-GENE-6465484|UniProtKB=B3DM35	LOC100170599 protein	ISS	15298723	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	RCA	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00011	Blood coagulation	P00406	Fibrinogen	XENTR|Xenbase=XB-GENE-483216|UniProtKB=B0JZ09	Fgb protein	ISS	95369693	PubMed	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	CANLF|Ensembl=ENSCAFG00000010476|UniProtKB=F1PS94	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00018	EGF receptor signaling pathway	P00562	p38	CAEEL|WormBase=WBGene00004056|UniProtKB=Q8MXI4	Mitogen-activated protein kinase pmk-2	ISS	10514528	PubMed	PTHR24055:SF154	MITOGEN-ACTIVATED PROTEIN KINASE PMK-2
P00005	Angiogenesis	P00236	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02787	Vitamin B6 metabolism	P03227	Phosphoserine transaminase	MACMU|Ensembl=ENSMMUG00000011868|UniProtKB=F7H2J8	Phosphoserine aminotransferase	ISS	20886743	gi	PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00048	PI3 kinase pathway	P01192	p110	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01311	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	IDA	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BRAFL|Gene=BRAFLDRAFT_220697|UniProtKB=C3ZSF0	Putative uncharacterized protein	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04393	Ras Pathway	P04569	Cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MACMU|Ensembl=ENSMMUG00000005876|UniProtKB=Q28524	Beta-3 adrenergic receptor	IDA	11943840	PubMed	PTHR24248:SF3	BETA-3 ADRENERGIC RECEPTOR
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00047	PDGF signaling pathway	P01173	STAT	MOUSE|MGI=MGI=103038|UniProtKB=P42227	Signal transducer and activator of transcription 3	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P02726	Aminobutyrate degradation	P02824	Succinate semi-aldehyde dehydrogenase	MOUSE|MGI=MGI=2441982|UniProtKB=Q8BWF0	Succinate-semialdehyde dehydrogenase, mitochondrial	ISS	12891648	PubMed	PTHR43353:SF5	SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00045	Notch signaling pathway	P01119	NIct	MOUSE|MGI=MGI=97364|UniProtKB=O35516	Neurogenic locus notch homolog protein 2	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00005	Angiogenesis	P00203	Erk	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01173	STAT	MOUSE|MGI=MGI=103038|UniProtKB=P42227	Signal transducer and activator of transcription 3	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MONDO|Ensembl=ENSMODG00000020204|UniProtKB=F6SED9	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00021	FGF signaling pathway	P00631	Grb2	BOVIN|Ensembl=ENSBTAG00000003707|UniProtKB=A6QLK6	GRB2-related adapter protein	ISS	8051109	PubMed	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P00006	Apoptosis signaling pathway	P00303	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	3136397	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04393	Ras Pathway	P04542	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00570	PKA	CAEEL|WormBase=WBGene00002189|UniProtKB=P21137	cAMP-dependent protein kinase catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	HUMAN|HGNC=11640|UniProtKB=Q9HCS4	Transcription factor 7-like 1	TAS	11266476	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00045	Notch signaling pathway	P01114	Ntm	HUMAN|HGNC=7881|UniProtKB=P46531	Neurogenic locus notch homolog protein 1	IGI	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00009	Axon guidance mediated by netrin	P00359	NFAT	PANTR|Ensembl=ENSPTRG00000006218|UniProtKB=H2Q834	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	HUMAN|HGNC=16810|UniProtKB=P57771	Regulator of G-protein signaling 8	ISS	8756726	PubMed	PTHR10845:SF147	REGULATOR OF G-PROTEIN SIGNALING 8
P00045	Notch signaling pathway	P01114	Ntm	HUMAN|HGNC=7883|UniProtKB=Q9UM47	Neurogenic locus notch homolog protein 3	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00059	p53 pathway	P01486	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	IC	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00057	Wnt signaling pathway	P01438	PP2A	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00060	Ubiquitin proteasome pathway	P01490	E3	MOUSE|MGI=MGI=1858216|UniProtKB=P61087	Ubiquitin-conjugating enzyme E2 K	ISS			PTHR44020:SF2	UBIQUITIN-CONJUGATING ENZYME E2 K
P00029	Huntington disease	P00780	Microtubule	DANRE|ZFIN=ZDB-GENE-030131-7741|UniProtKB=Q6PE34	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF93	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MOUSE|MGI=MGI=2444552|UniProtKB=Q8BFZ3	Beta-actin-like protein 2	IDA	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P04393	Ras Pathway	P04547	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	RCA	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00011	Blood coagulation	P00453	FXIII	HUMAN|HGNC=3534|UniProtKB=P05160	Coagulation factor XIII B chain	ISS	9961357	gi	PTHR19325:SF314	COAGULATION FACTOR XIII B CHAIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	88241036	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CHICK|Ensembl=ENSGALG00000005401|UniProtKB=Q3L251	Protein Wnt	TAS	11266476	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	CHICK|Ensembl=ENSGALG00000019382|UniProtKB=E1BWK1	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00018	EGF receptor signaling pathway	P00552	Ras	XENTR|Xenbase=XB-GENE-494548|UniProtKB=F7EC26	Uncharacterized protein	ISS	10825661	PubMed	PTHR24070:SF186	GTPASE KRAS
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00036	Interleukin signaling pathway	P00964	p90RSK	ORNAN|Ensembl=ENSOANG00000010658|UniProtKB=F6V2V1	Uncharacterized protein	ISS	10480933	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00053	T cell activation	P01331	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05916	Opioid prodynorphin pathway	P06002	G-protein	DROME|FlyBase=FBgn0004623|UniProtKB=P29829	Guanine nucleotide-binding protein subunit beta-2	IC			PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00021	FGF signaling pathway	P00627	ERK1-2	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	BOVIN|Ensembl=ENSBTAG00000004279|UniProtKB=P61585	Transforming protein RhoA	ISS	12039949	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P06587	Nicotine pharmacodynamics pathway	P06596	Grb2	XENTR|Xenbase=XB-GENE-6070000|UniProtKB=Q66II3	Growth factor receptor-bound protein 2	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	CAEEL|WormBase=WBGene00006932|UniProtKB=Q9TXI7	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00048	PI3 kinase pathway	P01188	Gbetagamma	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P02757	O-antigen biosynthesis	P03052	N-acetylglucosamine-1-phosphate uridyltransferase	RHOBA|EnsemblGenome=RB6841|UniProtKB=Q7UPM5	UDP-N-acetylglucosamine pyrophosphorylase	ISS			PTHR43584:SF3	BIFUNCTIONAL PROTEIN GLMU
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00012	Cadherin signaling pathway	P00470	F-actin	CHICK|Gene=ACTR2|UniProtKB=P53488	Actin-related protein 2	ISS	11889126	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	RAT|RGD=61862|UniProtKB=P19491	Glutamate receptor 2	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00965	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00054	Toll receptor signaling pathway	P01369	MKK1	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00632	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01451	Galpha	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IDA	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P06664	Gonadotropin-releasing hormone receptor pathway	P06739	MEK1/2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	RCA	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	PANTR|Ensembl=ENSPTRG00000006368|UniProtKB=H2Q8C3	Uncharacterized protein	ISS	15032587	PubMed	PTHR44282:SF2	SUPPRESSOR OF CYTOKINE SIGNALING 4
P05917	Opioid proopiomelanocortin pathway	P06008	ACTH	HUMAN|HGNC=9201|UniProtKB=P01189	Pro-opiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00019	Endothelin signaling pathway	P00572	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MOUSE|MGI=MGI=1333815|UniProtKB=Q9Z0D9	CX3C chemokine receptor 1	IDA	12569158	PubMed	PTHR10489:SF637	CX3C CHEMOKINE RECEPTOR 1
P02752	Mannose metabolism	P03015	GDP-Mannose 4,6-dehydratase	CAEEL|WormBase=WBGene00000266|UniProtKB=Q18801	GDP-mannose 4,6 dehydratase 1	IEA	9851916	PubMed	PTHR43715:SF1	GDP-MANNOSE 4,6 DEHYDRATASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04393	Ras Pathway	P04567	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00036	Interleukin signaling pathway	P00990	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00045	Notch signaling pathway	P01103	Next	RAT|RGD=3188|UniProtKB=Q9QW30	Neurogenic locus notch homolog protein 2	IEP	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P05915	Opioid proenkephalin pathway	P05994	G-protein	SCLS1|EnsemblGenome=SS1G_03482|UniProtKB=A7EDU2	Guanine nucleotide-binding protein beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00547	PP2A	XENTR|Xenbase=XB-GENE-957248|UniProtKB=Q6GLE6	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01202	p85	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00920	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00019	Endothelin signaling pathway	P00591	PLCbeta	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00007	Axon guidance mediated by semaphorins	P00333	RhoGEF	RAT|RGD=620951|UniProtKB=Q9Z1I6	Rho guanine nucleotide exchange factor 1	ISS	12024019	PubMed	PTHR12673:SF122	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00017	DNA replication	P00529	RFC	MOUSE|MGI=MGI=97891|UniProtKB=P35601	Replication factor C subunit 1	RCA			PTHR23389:SF22	REPLICATION FACTOR C SUBUNIT 1
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MONDO|Ensembl=ENSMODG00000018204|UniProtKB=F6PGX6	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04395	Vasopressin synthesis	P04594	Neurophysin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05913	Enkephalin release	P05977	G-Protein (s)	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00018	EGF receptor signaling pathway	P00543	ERK1-2	YEAST|SGD=S000001072|UniProtKB=Q00772	Mitogen-activated protein kinase SLT2/MPK1	ISS			PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00010	B cell activation	P00391	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00964	p90RSK	HUMAN|HGNC=10430|UniProtKB=Q15418	Ribosomal protein S6 kinase alpha-1	ISS	12213813	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	RCA			PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CHICK|Ensembl=ENSGALG00000005396|UniProtKB=Q2LMP1	Protein Wnt-3a	TAS	8717036	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P00045	Notch signaling pathway	P01116	Delta	MACMU|Ensembl=ENSMMUG00000020038|UniProtKB=F7GDI5	Uncharacterized protein	ISS			PTHR24052:SF11	PROTEIN DELTA HOMOLOG 1
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00022	General transcription by RNA polymerase I	P00651	TAF-IA	CANLF|Ensembl=ENSCAFG00000001622|UniProtKB=E2RN76	Uncharacterized protein	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00986	eNOS	MOUSE|MGI=MGI=97362|UniProtKB=P70313	Nitric oxide synthase, endothelial	ISS	9837777	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00045	Notch signaling pathway	P01114	Ntm	MACMU|Ensembl=ENSMMUG00000018375|UniProtKB=F7H1D5	Neurogenic locus notch homolog protein 2 isoform 1 preproprotein	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00047	PDGF signaling pathway	P01162	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00057	Wnt signaling pathway	P01452	NFAT	HUMAN|HGNC=7777|UniProtKB=Q12968	Nuclear factor of activated T-cells, cytoplasmic 3	IDA	9133421	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00036	Interleukin signaling pathway	P00970	Interleukin	RAT|RGD=621475|UniProtKB=Q99MF5	Interleukin-11	IC			PTHR16922:SF0	INTERLEUKIN-11
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	DANRE|ZFIN=ZDB-GENE-010705-1|UniProtKB=Q90Z40	Guanine nucleotide-binding protein subunit gamma	IDA	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00011	Blood coagulation	P00449	GP Ibalpha	HUMAN|HGNC=4439|UniProtKB=P07359	Platelet glycoprotein Ib alpha chain	IDA	91271273	PubMed	PTHR45534:SF1	PLATELET GLYCOPROTEIN IB ALPHA CHAIN
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00054	Toll receptor signaling pathway	P01380	TLR1,2,6	PANTR|Ensembl=ENSPTRG00000015986|UniProtKB=B3Y641	Toll-like receptor	ISS			PTHR24365:SF422	TOLL-LIKE RECEPTOR 6
P00012	Cadherin signaling pathway	P00470	F-actin	TRIAD|EnsemblGenome=TriadG49626|UniProtKB=B3RKR4	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	CAEEL|WormBase=WBGene00004769|UniProtKB=P52166	Presenilin sel-12	IDA	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P04392	P53 pathway feedback loops 1	G04683	Cop-1	MOUSE|MGI=MGI=1347046|UniProtKB=Q9R1A8	E3 ubiquitin-protein ligase RFWD2	IDA	15103385	PubMed	PTHR44080:SF1	E3 UBIQUITIN-PROTEIN LIGASE RFWD2
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	MACMU|Ensembl=ENSMMUG00000013535|UniProtKB=F6WIE8	Serine hydroxymethyltransferase	ISS			PTHR11680:SF21	SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC
P04395	Vasopressin synthesis	P04593	Glycopeptide	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	IC	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00029	Huntington disease	G01531	BDNF	MOUSE|MGI=MGI=88145|UniProtKB=P21237	Brain-derived neurotrophic factor	ISS	11408619	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000006232|UniProtKB=H2Q845	Serine/threonine-protein kinase	ISS	8078925	PubMed	PTHR22968:SF9	SERINE/THREONINE-PROTEIN KINASE D1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000007084|UniProtKB=H2Q9G5	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000003762|UniProtKB=A5PJS1	GNB5 protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00010	B cell activation	P00391	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	PANTR|Ensembl=ENSPTRG00000001102|UniProtKB=H2QZR9	RAP1A, member of RAS oncogene family	ISS	1904317	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P02738	De novo purine biosynthesis	P02892	5-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase	HUMAN|HGNC=291|UniProtKB=P30566	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P00048	PI3 kinase pathway	P01188	Gbetagamma	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00013	Cell cycle	P00483	Cyclin E	PANTR|Ensembl=ENSPTRG00000010782|UniProtKB=H2R677	Cyclin E1	ISS	12729791	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00010	B cell activation	P00402	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00049	Parkinson disease	P01211	ERK	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	IDA	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00047	PDGF signaling pathway	P01167	Ets	MACMU|Ensembl=ENSMMUG00000002432|UniProtKB=F6PLD5	E74-like factor 5	ISS	15298723	PubMed	PTHR11849:SF15	ETS-RELATED TRANSCRIPTION FACTOR ELF-5
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IDA	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	BRAFL|Gene=BRAFLDRAFT_209131|UniProtKB=C3ZAF6	Putative uncharacterized protein	ISS			PTHR24070:SF382	RAS-RELATED PROTEIN RAP-1B
P04395	Vasopressin synthesis	P04597	Signal Peptide	MACMU|Ensembl=ENSMMUG00000010678|UniProtKB=F7AXI7	Uncharacterized protein	ISS	192340	OMIM	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00005	Angiogenesis	P00206	Wnt	RAT|RGD=1311441|UniProtKB=A0A0G2K3B7	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	ARATH|TAIR=AT4G27370|UniProtKB=F4JIU4	Myosin-4	IC			PTHR13140:SF702	MYOSIN-2-RELATED
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000035697|UniProtKB=Q28024	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IDA	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1693|UniProtKB=Q6P967	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	ISS	10514528	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P05913	Enkephalin release	P05972	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00005	Angiogenesis	P00187	beta catenin	MONDO|Ensembl=ENSMODG00000011192|UniProtKB=F6SRK5	Uncharacterized protein	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00012	Cadherin signaling pathway	P00470	F-actin	CAEBR|Gene=CBG02162|UniProtKB=A8WS33	Protein CBG02162	ISS	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00034	Integrin signalling pathway	P00907	ERK	RAT|RGD=1304575|UniProtKB=B5DF98	Map3k3 protein	ISS			PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00006	Apoptosis signaling pathway	P00280	PACT	PANTR|Ensembl=ENSPTRG00000012688|UniProtKB=H2QJ21	Protein kinase, interferon-inducible double stranded RNA dependent activator	ISS			PTHR10910:SF8	INTERFERON-INDUCIBLE DOUBLE-STRANDED RNA-DEPENDENT PROTEIN KINASE ACTIVATOR A
P05916	Opioid prodynorphin pathway	P06002	G-protein	RAT|RGD=69319|UniProtKB=P54313	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P05916	Opioid prodynorphin pathway	P06001	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=12787|UniProtKB=P56706	Protein Wnt-7b	IDA	8717036	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00052	TGF-beta signaling pathway	P01284	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00036	Interleukin signaling pathway	P00965	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	BOVIN|Gene=PSMD13|UniProtKB=Q5E964	26S proteasome non-ATPase regulatory subunit 13	ISS	99239941	PubMed	PTHR10539:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13
P02775	Salvage pyrimidine ribonucleotides	P03155	Cytosine deaminase	YEAST|SGD=S000003572|UniProtKB=P47058	tRNA-specific adenosine deaminase subunit TAD2	ISS			PTHR11079:SF92	TRNA-SPECIFIC ADENOSINE DEAMINASE 2
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	DROME|FlyBase=FBgn0264000|UniProtKB=M9PHV5	Glutamate receptor IB, isoform B	IC	12446127	PubMed	PTHR18966:SF270	GLUTAMATE RECEPTOR 1-RELATED
P00010	B cell activation	P00373	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IGI	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00539	14-3-3	CAEEL|WormBase=WBGene00003920|UniProtKB=P41932	14-3-3-like protein 1	IGI	10407019	PubMed	PTHR18860:SF21	14-3-3-LIKE PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IDA	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MOUSE|MGI=MGI=95777|UniProtKB=Q6R0H7	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas	ISS	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	ANOGA|EnsemblGenome=AGAP001394|UniProtKB=F5HMS4	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00056	VEGF signaling pathway	P01417	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01001	KA4	MOUSE|MGI=MGI=95817|UniProtKB=Q8BMF5	Glutamate receptor ionotropic, kainate 4	ISS	12871085	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00009	Axon guidance mediated by netrin	P00364	cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00018	EGF receptor signaling pathway	P00557	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	14526383	PubMed	PTHR10048:SF14	PI-3 KINASE
P00029	Huntington disease	P00807	Actin	SCHMA|EnsemblGenome=Smp_161920|UniProtKB=G4VSW5	Putative actin	IDA	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00010	B cell activation	P00381	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05915	Opioid proenkephalin pathway	P05994	G-protein	PANTR|Ensembl=ENSPTRG00000000843|UniProtKB=H2QZN8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00021	FGF signaling pathway	P00627	ERK1-2	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01411	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05940	GRK5	MACMU|Ensembl=ENSMMUG00000004596|UniProtKB=F6Q976	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF27	G PROTEIN-COUPLED RECEPTOR KINASE 5
P00021	FGF signaling pathway	P00633	Ras	CAEBR|Gene=CBG06092|UniProtKB=A8X0X5	Protein CBR-LET-60	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00048	PI3 kinase pathway	P01177	P110ACT	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00371	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00014	Cholesterol biosynthesis	P00497	Anosterol synthase	PANTR|Ensembl=ENSPTRG00000014017|UniProtKB=H2R1N5	Terpene cyclase/mutase family member	ISS	P38604	SPACC	PTHR11764:SF20	LANOSTEROL SYNTHASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00048	PI3 kinase pathway	P01188	Gbetagamma	DICDI|dictyBase=DDB_G0277143|UniProtKB=P36408	Guanine nucleotide-binding protein subunit beta	IC	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00036	Interleukin signaling pathway	P00990	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	15210700	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	STRPU|Gene=CYIIIB|UniProtKB=P18499	Actin, cytoskeletal 3B	IC	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	IDA	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00053	T cell activation	P01330	IKK	RAT|RGD=621375|UniProtKB=Q9QY78	Inhibitor of nuclear factor kappa-B kinase subunit beta	IGI	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000002339|UniProtKB=H2R368	Uncharacterized protein	ISS	20088160	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	PANTR|Ensembl=ENSPTRG00000020039|UniProtKB=H2R9W1	Uncharacterized protein	ISS	12135927	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00029	Huntington disease	P00812	Caspase 3	DANRE|ZFIN=ZDB-GENE-011210-1|UniProtKB=B8JK21	Uncharacterized protein	IDA	9323209	PubMed	PTHR10454:SF198	CASPASE-3
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	MOUSE|MGI=MGI=95753|UniProtKB=P26443	Glutamate dehydrogenase 1, mitochondrial	ISS			PTHR11606:SF13	GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL
P05734	Synaptic vesicle trafficking	P05775	Synapsin	MOUSE|MGI=MGI=103020|UniProtKB=Q64332	Synapsin-2	ISS	600755	OMIM	PTHR10841:SF20	SYNAPSIN-2
P00005	Angiogenesis	P00223	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	HUMAN|HGNC=1956|UniProtKB=Q15822	Neuronal acetylcholine receptor subunit alpha-2	ISS	85270494	PubMed	PTHR18945:SF757	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-2
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00587	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00782	alpha-Adaptin	YEAST|SGD=S000000133|UniProtKB=P38065	AP-2 complex subunit alpha	IDA	11532990	PubMed	PTHR22780:SF4	AP-2 COMPLEX SUBUNIT ALPHA-2
P00034	Integrin signalling pathway	P00925	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	IDA	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00017	DNA replication	P00527	Histones	CAEEL|WormBase=WBGene00001876|UniProtKB=P08898	Histone H3	ISS	12413958	PubMed	PTHR11426:SF167	HISTONE H3.1
P00054	Toll receptor signaling pathway	P01369	MKK1	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06739	MEK1/2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	RCA	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00047	PDGF signaling pathway	P01145	c-fos	MOUSE|MGI=MGI=99961|UniProtKB=Q64705	Upstream stimulatory factor 2	ISS			PTHR12565:SF11	UPSTREAM STIMULATORY FACTOR 2
P00006	Apoptosis signaling pathway	P00269	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	11204774	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	PANTR|Ensembl=ENSPTRG00000014841|UniProtKB=H2QMG2	Uncharacterized protein	ISS	6753462	gi	PTHR10489:SF664	C-C CHEMOKINE RECEPTOR TYPE 9
P00057	Wnt signaling pathway	P01457	GBeta	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	P01480	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00747	Rhodopsin	ORNAN|Ensembl=ENSOANG00000003778|UniProtKB=A4ZIS8	Rhodopsin	ISS	1634520	PubMed	PTHR24240:SF15	RHODOPSIN
P00029	Huntington disease	P00807	Actin	RAT|RGD=628837|UniProtKB=P60711	Actin, cytoplasmic 1	IDA	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00010	B cell activation	P00402	Jnk	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	RCA	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=97614|UniProtKB=Q8R3B1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	12860966	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	RAT|RGD=3567|UniProtKB=P49799	Regulator of G-protein signaling 4	ISS	9774420	PubMed	PTHR10845:SF184	REGULATOR OF G-PROTEIN SIGNALING 4
P00045	Notch signaling pathway	G01541	E(spl)-C genes	XENTR|Xenbase=XB-GENE-486694|UniProtKB=Q66KK8	Hairy/enhancer-of-split related with YRPW motif protein 1	ISS	12424520	PubMed	PTHR10985:SF78	HAIRY/ENHANCER-OF-SPLIT RELATED WITH YRPW MOTIF PROTEIN 1
P00006	Apoptosis signaling pathway	P00313	IKK	MOUSE|MGI=MGI=1338071|UniProtKB=O88351	Inhibitor of nuclear factor kappa-B kinase subunit beta	IDA	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00059	p53 pathway	P01486	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	IPI	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	EMENI|EnsemblGenome=CADANIAG00006684|UniProtKB=G5EB66	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00052	TGF-beta signaling pathway	P01286	TGFbeta	RAT|RGD=62074|UniProtKB=P18331	Inhibin beta A chain	TAS	9395284	PubMed	PTHR11848:SF133	INHIBIN BETA A CHAIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	PANTR|Gene=CXCR2|UniProtKB=Q28807	C-X-C chemokine receptor type 2 (Fragment)	ISS	10741397	PubMed	PTHR10489:SF689	C-X-C CHEMOKINE RECEPTOR TYPE 2
P00034	Integrin signalling pathway	P00936	PI3K	DROME|FlyBase=FBgn0015278|UniProtKB=Q7K3H0	LD28067p	IPI	14526383	PubMed	PTHR10048:SF64	LD28067P
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	15737619	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00029	Huntington disease	P00775	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	ORNAN|Ensembl=ENSOANG00000004797|UniProtKB=F7FFR0	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MOUSE|MGI=MGI=95819|UniProtKB=P35438	Glutamate receptor ionotropic, NMDA 1	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04393	Ras Pathway	P04559	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	DANRE|ZFIN=ZDB-GENE-020125-3|UniProtKB=E7F1V8	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06861	MAP4Ks	MOUSE|MGI=MGI=1349394|UniProtKB=P97820	Mitogen-activated protein kinase kinase kinase kinase 4	RCA			PTHR24361:SF225	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 4
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	TAS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000023940|UniProtKB=F6RFW8	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000014807|UniProtKB=F6W548	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00005	Angiogenesis	P00182	p38MAPK	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	MOUSE|MGI=MGI=1917834|UniProtKB=Q8BTW9	Serine/threonine-protein kinase PAK 4	ISS			PTHR24361:SF345	SERINE/THREONINE-PROTEIN KINASE PAK 4
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00591	PLCbeta	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00059	p53 pathway	P04623	CBP	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	IDA	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	10514528	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00019	Endothelin signaling pathway	P00566	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	RAT|RGD=2734|UniProtKB=Q01812	Glutamate receptor ionotropic, kainate 4	ISS	12871085	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00025	Hedgehog signaling pathway	P00685	Smoothened	DANRE|ZFIN=ZDB-GENE-980526-89|UniProtKB=Q5RH73	Uncharacterized protein	IDA	12606279	PubMed	PTHR11309:SF35	SMOOTHENED HOMOLOG
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00017	DNA replication	P00533	Pol delta	RAT|RGD=1304954|UniProtKB=Q6AXY4	DNA polymerase delta subunit 2	ISS	96079106	PubMed	PTHR10416:SF0	DNA POLYMERASE DELTA SUBUNIT 2
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P05918	p38 MAPK pathway	P06026	MEKK4	RAT|RGD=1311192|UniProtKB=A0A0G2K3R1	Protein Map3k4	ISS	602425	OMIM	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05916	Opioid prodynorphin pathway	P06003	dynorphin	MOUSE|MGI=MGI=97535|UniProtKB=O35417	Proenkephalin-B	RCA	131330	OMIM	PTHR11438:SF4	PROENKEPHALIN-B
P00010	B cell activation	P00371	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00021	FGF signaling pathway	P00633	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00047	PDGF signaling pathway	P01151	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	HUMAN|HGNC=4573|UniProtKB=P42263	Glutamate receptor 3	ISS	10331083	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=4595|UniProtKB=Q14832	Metabotropic glutamate receptor 3	IDA	9407094	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00048	PI3 kinase pathway	P01199	Galpha	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01451	Galpha	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	YEAST|SGD=S000005738|UniProtKB=P18851	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01465	Ggamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Gene=PCDHB2|UniProtKB=Q5DRD2	Protocadherin beta-2	ISS	8120095	PubMed	PTHR24028:SF77	PROTOCADHERIN BETA-2
P00010	B cell activation	P00375	Calmodulin	BOVIN|Ensembl=ENSBTAG00000014583|UniProtKB=P62157	Calmodulin	ISS	9753452	PubMed	PTHR23050:SF335	CALMODULIN, STRIATED MUSCLE
P00009	Axon guidance mediated by netrin	P00366	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	10802295	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00055	Transcription regulation by bZIP transcription factor	P01395	TFIIE	MONDO|Ensembl=ENSMODG00000019005|UniProtKB=F7CP70	Transcription initiation factor IIE subunit beta	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014262|UniProtKB=F7BYS8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02918	dUTP pyrophosphatase	YEAST|SGD=S000000456|UniProtKB=P33317	Deoxyuridine 5'-triphosphate nucleotidohydrolase	ISS			PTHR11241:SF0	BCDNA.LD08534
P00005	Angiogenesis	P00203	Erk	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01162	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95809|UniProtKB=P23819	Glutamate receptor 2	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	IDA	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00046	Oxidative stress response	P01135	p38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	TAS	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00056	VEGF signaling pathway	P01418	Paxillin	BOVIN|Ensembl=ENSBTAG00000002391|UniProtKB=Q3MHZ4	Transforming growth factor beta-1-induced transcript 1 protein	ISS			PTHR24216:SF27	TRANSFORMING GROWTH FACTOR BETA-1-INDUCED TRANSCRIPT 1 PROTEIN
P00005	Angiogenesis	P00206	Wnt	PANTR|Ensembl=ENSPTRG00000004892|UniProtKB=H2Q5U3	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	RAT|RGD=2738|UniProtKB=Q00960	Glutamate receptor ionotropic, NMDA 2B	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00887	IRS 1-4	HUMAN|HGNC=6125|UniProtKB=P35568	Insulin receptor substrate 1	TAS	15110093	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00034	Integrin signalling pathway	P00925	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	TAS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04550	Ral	CANLF|Ensembl=ENSCAFG00000004844|UniProtKB=E2RLB2	Uncharacterized protein	ISS	11025226	PubMed	PTHR24070:SF199	RAS-RELATED PROTEIN RAL-B
P06664	Gonadotropin-releasing hormone receptor pathway	P06810	GR	MOUSE|MGI=MGI=95824|UniProtKB=P06537	Glucocorticoid receptor	RCA			PTHR24084:SF4	GLUCOCORTICOID RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	RCA			PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	HUMAN|HGNC=11532|UniProtKB=Q15573	TATA box-binding protein-associated factor RNA polymerase I subunit A	ISS	600075	OMIM	PTHR32122:SF1	TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT A
P00010	B cell activation	P00379	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01160	IP3 receptor	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	8387895	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00049	Parkinson disease	P01212	p38 MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00054	Toll receptor signaling pathway	P01357	MEKK1	RAT|RGD=620966|UniProtKB=Q62925	Mitogen-activated protein kinase kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	PANTR|Ensembl=ENSPTRG00000023062|UniProtKB=H2R2U1	Catenin (Cadherin-associated protein), beta 1, 88kDa	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P02726	Aminobutyrate degradation	P02824	Succinate semi-aldehyde dehydrogenase	RAT|RGD=621422|UniProtKB=P51650	Succinate-semialdehyde dehydrogenase, mitochondrial	ISS	12891648	PubMed	PTHR43353:SF5	SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL
P00010	B cell activation	P00379	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00034	Integrin signalling pathway	P00944	Actin	PANTR|Ensembl=ENSPTRG00000009762|UniProtKB=H2QE24	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	7667318	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00035	Interferon-gamma signaling pathway	P00960	PTP	BOVIN|Ensembl=ENSBTAG00000002048|UniProtKB=F1N339	Tyrosine-protein phosphatase non-receptor type	ISS	1382983	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DANRE|ZFIN=ZDB-GENE-041001-104|UniProtKB=Q5TZD4	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CAEBR|Gene=CBG02161|UniProtKB=A8WS32	Protein CBG02161	ISS	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00247	Tie2	MACMU|Ensembl=ENSMMUG00000006080|UniProtKB=F6VW12	Angiopoietin-1 receptor	ISS	1630810	PubMed	PTHR24416:SF125	ANGIOPOIETIN-1 RECEPTOR
P00009	Axon guidance mediated by netrin	P00359	NFAT	CANLF|Ensembl=ENSCAFG00000011625|UniProtKB=F1PDD9	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-8225|UniProtKB=Q7SZZ5	Uncharacterized protein	ISS			PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05731	GABA-B receptor II signaling	P05755	Gbeta	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00021	FGF signaling pathway	P00629	PP2A	MOUSE|MGI=MGI=2388479|UniProtKB=Q6PD03	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform	ISS	10092233	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00045	Notch signaling pathway	P01120	NIcs	MOUSE|MGI=MGI=97364|UniProtKB=O35516	Neurogenic locus notch homolog protein 2	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DROME|FlyBase=FBgn0000042|UniProtKB=P10987	Actin-5C	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Ensembl=ENSCAFG00000011689|UniProtKB=E2QZY2	Uncharacterized protein	ISS	12093103	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00006	Apoptosis signaling pathway	P00307	ELF2alpha	YEAST|SGD=S000003767|UniProtKB=P20459	Eukaryotic translation initiation factor 2 subunit alpha	ISS			PTHR10602:SF0	EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1
P06959	CCKR signaling map	P07150	beta-catenin	HUMAN|HGNC=2514|UniProtKB=P35222	Catenin beta-1	RCA	20637111	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00029	Huntington disease	P00777	CBP	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P02728	Arginine biosynthesis	P02840	Argininosuccinate synthase	SYNY3|EnsemblGenome=BAA18841|UniProtKB=P77973	Argininosuccinate synthase	ISS			PTHR11587:SF2	ARGININOSUCCINATE SYNTHASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	P01449	Nemo-like Kinase	HUMAN|HGNC=29858|UniProtKB=Q9UBE8	Serine/threonine-protein kinase NLK	IDA	10683140	PubMed	PTHR24055:SF179	SERINE/THREONINE-PROTEIN KINASE NLK
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	DANRE|ZFIN=ZDB-GENE-050417-59|UniProtKB=Q15KE4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00054	Toll receptor signaling pathway	P01352	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02781	Threonine biosynthesis	P03192	Aspartate semialdehyde dehydrogenase	BACSU|EnsemblGenome=BSU16750|UniProtKB=Q04797	Aspartate-semialdehyde dehydrogenase	ISS			PTHR10174:SF2	ASPARTATE-SEMIALDEHYDE DEHYDROGENASE
P00021	FGF signaling pathway	P00628	JNK1-3	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00029	Huntington disease	P00806	TAFII130	DROME|FlyBase=FBgn0010280|UniProtKB=P47825	Transcription initiation factor TFIID subunit 4	IDA	10973244	PubMed	PTHR15138:SF14	IP01149P-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	MACMU|Ensembl=ENSMMUG00000012305|UniProtKB=F7DLC9	Tyrosine-protein kinase receptor	ISS	2877871	PubMed	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	CRYNJ|EnsemblGenome=CND03830|UniProtKB=Q5KI86	Uncharacterized protein	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00059	p53 pathway	P01485	p53	MACMU|Ensembl=ENSMMUG00000008639|UniProtKB=P56424	Cellular tumor antigen p53	TAS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95816|UniProtKB=B1AS29	Glutamate receptor ionotropic, kainate 3	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000008362|UniProtKB=F7HPU3	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF9	PROTOCADHERIN-18
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ORYSJ|EnsemblGenome=OS10G0510000|UniProtKB=A3C6D7	Actin-2	IC	10974003	PubMed	PTHR11937:SF252	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00624	14-3-3	BOVIN|Ensembl=ENSBTAG00000000236|UniProtKB=P63103	14-3-3 protein zeta/delta	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P05916	Opioid prodynorphin pathway	P06002	G-protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00636	FGFR1-4	RAT|RGD=620713|UniProtKB=Q04589	Fibroblast growth factor receptor 1	IGI	9989949	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06786	ERK1/2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	RCA	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	TAKRU|Ensembl=ENSTRUG00000015213|UniProtKB=H2UPJ1	Uncharacterized protein	ISS	20112749	PubMed	PTHR18966:SF356	SUBFAMILY NOT NAMED
P05918	p38 MAPK pathway	P06021	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12874273	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00005	Angiogenesis	P00254	GTPase	SCLS1|EnsemblGenome=SS1G_03867|UniProtKB=A7EEX6	RhoA protein	ISS			PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00019	Endothelin signaling pathway	P00568	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	10395542	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00047	PDGF signaling pathway	P01160	IP3 receptor	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00551	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00567	PKG	MACMU|Ensembl=ENSMMUG00000010844|UniProtKB=F7G3L7	cGMP-dependent protein kinase	ISS	10565812	PubMed	PTHR24353:SF68	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	MACMU|Ensembl=ENSMMUG00000012005|UniProtKB=F7H091	Metabotropic glutamate receptor 2 isoform a	ISS	9407094	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	EMENI|EnsemblGenome=CADANIAG00006296|UniProtKB=Q5ASG1	Putative synaptobrevin homologue SNC1/2 (Eurofung)	ISS			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00005	Angiogenesis	P00211	GSK3beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00012	Cadherin signaling pathway	P00462	Casein kinase II	DROME|FlyBase=FBgn0026136|UniProtKB=O96863	Casein kinase II subunit beta'	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00006	Apoptosis signaling pathway	P00302	ATF	BOVIN|Gene=CREB1|UniProtKB=P27925	Cyclic AMP-responsive element-binding protein 1	ISS	11390664	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05731	GABA-B receptor II signaling	P05760	AC	RAT|RGD=619966|UniProtKB=F1LQT1	Adenylate cyclase 7	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00025	Hedgehog signaling pathway	P00689	Patched	CAEEL|WormBase=WBGene00004209|UniProtKB=Q09540	PaTChed family	ISS			PTHR10796:SF77	PROTEIN PATCHED
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	MOUSE|MGI=MGI=2150309|UniProtKB=Q4VA61	Down syndrome cell adhesion molecule-like protein 1 homolog	ISS			PTHR44107:SF3	DOWN SYNDROME CELL ADHESION MOLECULE-LIKE PROTEIN 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	DANRE|ZFIN=ZDB-GENE-050823-1|UniProtKB=Q1XHM0	Rhodopsin kinase	ISS	8260489	PubMed	PTHR24355:SF11	RHODOPSIN KINASE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	HALSA|EnsemblGenome=VNG_0869G|UniProtKB=Q9HR45	Transcription initiation factor IIB 4	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	2372396	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00021	FGF signaling pathway	P00645	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	8649368	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00013	Cell cycle	P00480	Proteasome	DROME|FlyBase=FBgn0015283|UniProtKB=P55035	26S proteasome non-ATPase regulatory subunit 4	ISS	22426069	PubMed	PTHR10223:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00859	NFkappaB	HUMAN|HGNC=7795|UniProtKB=Q00653	Nuclear factor NF-kappa-B p100 subunit	ISS	20151924	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DROME|FlyBase=FBgn0261854|UniProtKB=A1Z9X0	Atypical protein kinase C	ISS	3755548	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	DROME|FlyBase=FBgn0024920|UniProtKB=O76511	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	TAS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ARATH|TAIR=AT4G34460|UniProtKB=P49177	Guanine nucleotide-binding protein subunit beta	IC	11313908	PubMed	PTHR19850:SF48	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IDA	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00005	Angiogenesis	P00244	MAPKAPK2/3	BOVIN|Ensembl=ENSBTAG00000038107|UniProtKB=F1MCX5	Uncharacterized protein	ISS	10779545	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	HUMAN|HGNC=1952|UniProtKB=P20309	Muscarinic acetylcholine receptor M3	IDA	12181435	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	YEAST|SGD=S000003080|UniProtKB=P53040	Transcription initiation factor TFIID subunit 6	ISS			PTHR10221:SF9	TAF6-LIKE RNA POLYMERASE II P300/CBP-ASSOCIATED FACTOR-ASSOCIATED FACTOR 65 KDA SUBUNIT 6L
P00006	Apoptosis signaling pathway	P00313	IKK	BOVIN|Ensembl=ENSBTAG00000007591|UniProtKB=Q95KV1	Inhibitor of nuclear factor kappa-B kinase subunit alpha	ISS	9346484	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P02723	Adenine and hypoxanthine salvage pathway	P02813	Inosine phosphorylase	DROME|FlyBase=FBgn0035348|UniProtKB=M9PE19	Uncharacterized protein, isoform H	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9441|UniProtKB=P51817	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00006	Apoptosis signaling pathway	P00325	Bim	CANLF|Ensembl=ENSCAFG00000030412|UniProtKB=J9NWV6	Bcl-2-like protein 11	ISS	11859372	PubMed	PTHR12044:SF9	BCL-2-LIKE PROTEIN 11
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00049	Parkinson disease	P01211	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	STRPU|EnsemblGenome=SPU_018419|UniProtKB=W4YRI6	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04651	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00049	Parkinson disease	P01233	Elk-1	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	9644975	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00011	Blood coagulation	P00405	FVIII	CANLF|Gene=F8|UniProtKB=O18806	Coagulation factor VIII	ISS	2947308	gi	PTHR45309:SF1	COAGULATION FACTOR VIII
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00010	B cell activation	P00380	fos	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	TAS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00857	IkappaB	MOUSE|MGI=MGI=104741|UniProtKB=Q9Z1E3	NF-kappa-B inhibitor alpha	ISS	10869418	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	RAT|RGD=2742|UniProtKB=P23385	Metabotropic glutamate receptor 1	ISS	14614461	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00021	FGF signaling pathway	P00627	ERK1-2	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	HUMAN|HGNC=28487|UniProtKB=Q8NHS2	Putative aspartate aminotransferase, cytoplasmic 2	ISS			PTHR11879:SF6	ASPARTATE AMINOTRANSFERASE, CYTOPLASMIC 2-RELATED
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	RAT|RGD=2521|UniProtKB=P19020	D(3) dopamine receptor	RCA	1319557	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P06664	Gonadotropin-releasing hormone receptor pathway	P06787	SMAD1/5/8	MOUSE|MGI=MGI=1859993|UniProtKB=Q9JIW5	Mothers against decapentaplegic homolog 9	RCA	9395284	PubMed	PTHR13703:SF41	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MACMU|Ensembl=ENSMMUG00000009759|UniProtKB=F6ZIH3	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF504	MYOSIN-13
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00019	Endothelin signaling pathway	P00589	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	DANRE|ZFIN=ZDB-GENE-990415-199|UniProtKB=A3QJX7	Uncharacterized protein	IDA	11259498	PubMed	PTHR24229:SF74	SUBFAMILY NOT NAMED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00892	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12162872	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00021	FGF signaling pathway	P00628	JNK1-3	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00547	PP2A	STRPU|EnsemblGenome=SPU_025182|UniProtKB=W4ZAK5	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00078	Alpha1A/1B/1C	RAT|RGD=2055|UniProtKB=P43140	Alpha-1A adrenergic receptor	IC	6323229	PubMed	PTHR24248:SF16	ALPHA-1A ADRENERGIC RECEPTOR
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	CANLF|Ensembl=ENSCAFG00000000332|UniProtKB=F1P8E3	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	IDA	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04393	Ras Pathway	P04569	Cdc42	DAPPU|EnsemblGenome=DAPPUDRAFT_306746|UniProtKB=E9GYE9	Putative uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	IC	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00036	Interleukin signaling pathway	P00965	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	IDA	20451058	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02738	De novo purine biosynthesis	P02907	dADP kinase	BOVIN|Ensembl=ENSBTAG00000003025|UniProtKB=F1MCI2	Nucleoside diphosphate kinase	ISS			PTHR11349:SF70	NUCLEOSIDE DIPHOSPHATE KINASE 6
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00057	Wnt signaling pathway	P01451	Galpha	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	8787761	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	HUMAN|HGNC=4584|UniProtKB=Q05586	Glutamate receptor ionotropic, NMDA 1	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00019	Endothelin signaling pathway	P00586	Gq	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BOVIN|Ensembl=ENSBTAG00000005714|UniProtKB=Q3ZC07	Actin, alpha cardiac muscle 1	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00005	Angiogenesis	P00251	cPLA2	PANTR|Ensembl=ENSPTRG00000001787|UniProtKB=H2Q0T0	Phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P05916	Opioid prodynorphin pathway	P06002	G-protein	ANOGA|EnsemblGenome=AGAP001506|UniProtKB=Q7PXP3	AGAP001506-PA	IC			PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	PANTR|Ensembl=ENSPTRG00000003543|UniProtKB=H2Q3H4	Uncharacterized protein	ISS	608972	OMIM	PTHR22952:SF24	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 1
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P02740	De novo pyrimidine ribonucleotides biosythesis	P02927	Dihydrooratate oxidase	EMENI|EnsemblGenome=CADANIAG00007124|UniProtKB=G5EB61	Uncharacterized protein	ISS			PTHR43517:SF1	DIHYDROOROTATE DEHYDROGENASE  QUINONE , MITOCHONDRIAL
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00053	T cell activation	P01300	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00591	PLCbeta	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IGI	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00014	Cholesterol biosynthesis	P00493	Geranyl trans-transferase	CAEEL|WormBase=WBGene00011058|UniProtKB=O62336	Farnesyl DiPhosphate Synthetase	ISS	O64905	SPACC	PTHR11525:SF0	FARNESYL PYROPHOSPHATE SYNTHASE
P04398	p53 pathway feedback loops 2	P04657	P110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	RAT|RGD=2738|UniProtKB=Q00960	Glutamate receptor ionotropic, NMDA 2B	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g245773|UniProtKB=A7SJX9	Predicted protein	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00057	Wnt signaling pathway	P01457	GBeta	BRAFL|Gene=BRAFLDRAFT_220697|UniProtKB=C3ZSF0	Putative uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CANLF|Ensembl=ENSCAFG00000004930|UniProtKB=E2RFB5	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00045	Notch signaling pathway	P01101	Su(H)	BOVIN|Ensembl=ENSBTAG00000003602|UniProtKB=Q3SZ41	Recombining binding protein suppressor of hairless	ISS	9043084	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00047	PDGF signaling pathway	P01159	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	DROME|FlyBase=FBgn0036857|UniProtKB=Q8SXQ1	CG9629	IC			PTHR43521:SF1	ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE
P00005	Angiogenesis	P00253	Axin	RAT|RGD=69259|UniProtKB=O70240	Axin-2	ISS	12356903	PubMed	PTHR10845:SF103	AXIN-2
P00046	Oxidative stress response	P01122	TRX	BOVIN|Gene=TXN|UniProtKB=O97680	Thioredoxin	TAS	12115731	PubMed	PTHR10438:SF18	THIOREDOXIN
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00057	Wnt signaling pathway	P01438	PP2A	MONDO|Ensembl=ENSMODG00000019007|UniProtKB=F7C5Z9	Uncharacterized protein	ISS	12110603	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00036	Interleukin signaling pathway	P00990	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00034	Integrin signalling pathway	P00951	Jnk	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00256	PLC-gamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00021	FGF signaling pathway	P00640	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IGI	10799299	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IGI	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00005	Angiogenesis	P00206	Wnt	MONDO|Ensembl=ENSMODG00000001196|UniProtKB=F7GH85	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00005	Angiogenesis	P00254	GTPase	MOUSE|MGI=MGI=106028|UniProtKB=Q62159	Rho-related GTP-binding protein RhoC	ISS	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00052	TGF-beta signaling pathway	G01548	I-SMAD	DROME|FlyBase=FBgn0020493|UniProtKB=Q5U110	Mothers against decapentaplegic homolog	IGI	9335505	PubMed	PTHR13703:SF44	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MOUSE|MGI=MGI=104589|UniProtKB=P63268	Actin, gamma-enteric smooth muscle	IC	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00182	p38MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00562	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	ISS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DICDI|dictyBase=DDB_G0289489|UniProtKB=P07828	Actin-18	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	DANRE|ZFIN=ZDB-GENE-021010-2|UniProtKB=Q90WY5	Alpha-2B adrenergic receptor	IDA	11781138	PubMed	PTHR24248:SF111	ALPHA-2B ADRENERGIC RECEPTOR
P00056	VEGF signaling pathway	P01408	Akt/PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P02749	Leucine biosynthesis	P03001	3-Isopropylmalate dehydrogenase	MYCTU|EnsemblGenome=Rv2995c|UniProtKB=P9WKK9	3-isopropylmalate dehydrogenase	ISS			PTHR43275:SF1	D-MALATE DEHYDROGENASE  DECARBOXYLATING
P00046	Oxidative stress response	P01131	MKP5	MACMU|Ensembl=ENSMMUG00000004047|UniProtKB=F6ZR84	Uncharacterized protein	ISS			PTHR10159:SF293	DUAL SPECIFICITY PROTEIN PHOSPHATASE 12
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	IC	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	MOUSE|MGI=MGI=1276116|UniProtKB=B2RWS6	Histone acetyltransferase p300	ISS	10769018	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	TAS	9603989	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00018	EGF receptor signaling pathway	P00564	Rac	DICDI|dictyBase=DDB_G0286555|UniProtKB=P34147	Rho-related protein racA	IGI	12932731	PubMed	PTHR24072:SF183	RHO-RELATED PROTEIN RACA
P02738	De novo purine biosynthesis	P02909	GDP reductase	STRCO|EnsemblGenome=CAA18341|UniProtKB=O69981	Vitamin B12-dependent ribonucleotide reductase	ISS			PTHR43371:SF1	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00996	STAT	CANLF|Ensembl=ENSCAFG00000015509|UniProtKB=F1PNW8	Signal transducer and activator of transcription	ISS	20119183	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00009	Axon guidance mediated by netrin	P00366	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DANRE|ZFIN=ZDB-GENE-000322-1|UniProtKB=Q9I8V1	Actin, alpha 1, skeletal muscle	IC	11889126	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	IDA	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	XENTR|Xenbase=XB-GENE-481480|UniProtKB=Q5XGI6	Casein kinase 1, epsilon	ISS	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00036	Interleukin signaling pathway	P00990	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00057	Wnt signaling pathway	P01472	Histone deacetylase	YEAST|SGD=S000005274|UniProtKB=P32561	Histone deacetylase RPD3	IDA	10485845	PubMed	PTHR10625:SF141	HISTONE DEACETYLASE RPD3
P00020	FAS signaling pathway	P00595	Caspase7	MACMU|Ensembl=ENSMMUG00000001217|UniProtKB=F7DA15	Uncharacterized protein	ISS	14583630	PubMed	PTHR10454:SF31	CASPASE-7
P00012	Cadherin signaling pathway	P00470	F-actin	BOVIN|Gene=ACTG2|UniProtKB=Q5E9B5	Actin, gamma-enteric smooth muscle	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00045	Notch signaling pathway	P01099	Notch	HUMAN|HGNC=7884|UniProtKB=Q99466	Neurogenic locus notch homolog protein 4	ISS	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	MOUSE|MGI=MGI=96611|UniProtKB=P11835	Integrin beta-2	IDA	3487386	PubMed	PTHR10082:SF15	INTEGRIN BETA-2
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00045	Notch signaling pathway	P01101	Su(H)	TAKRU|Ensembl=ENSTRUG00000014798|UniProtKB=H2ULI5	Uncharacterized protein	ISS	12145413	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00019	Endothelin signaling pathway	P00591	PLCbeta	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	HUMAN|HGNC=1736|UniProtKB=P60953	Cell division control protein 42 homolog	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00059	p53 pathway	P04610	Cyclin E	MOUSE|MGI=MGI=88316|UniProtKB=Q61457	G1/S-specific cyclin-E1	ISS	6671698	gi	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00702	CPB	MOUSE|MGI=MGI=1916603|UniProtKB=Q9D2A5	Cyclic AMP-responsive element-binding protein 3-like protein 4	ISS			PTHR22952:SF105	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 4
P00030	Hypoxia response via HIF activation	P00819	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00371	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04393	Ras Pathway	P04556	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IDA	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00933	Crk	XENTR|Xenbase=XB-GENE-996357|UniProtKB=F6XER9	Uncharacterized protein	ISS	8649368	PubMed	PTHR19969:SF8	ADAPTER MOLECULE CRK
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02754	Methylcitrate cycle	P03031	2-Methylcitrate dehydratase	NEUCR|EnsemblGenome=EFNCRG00000000556|UniProtKB=Q7SHX3	2-methylcitrate dehydratase	ISS			PTHR16943:SF19	2-METHYLCITRATE DEHYDRATASE-RELATED
P04393	Ras Pathway	P04558	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04398	p53 pathway feedback loops 2	P04665	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00001	Adrenaline and noradrenaline biosynthesis	P00066	DOPA decarb.	RAT|RGD=2494|UniProtKB=P14173	Aromatic-L-amino-acid decarboxylase	ISS	107930	OMIM	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06786	ERK1/2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	RCA	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02738	De novo purine biosynthesis	P02902	ADP reductase	ANOGA|Gene=AgaP_AGAP010198|UniProtKB=Q5TNU6	Ribonucleoside-diphosphate reductase (Fragment)	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IDA	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00029	Huntington disease	P00788	Calpain	PANTR|Ensembl=ENSPTRG00000013108|UniProtKB=H2QJQ9	Uncharacterized protein	ISS	11675509	PubMed	PTHR10183:SF30	CALPAIN-10
P00006	Apoptosis signaling pathway	P00260	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00923	Arf1	TAKRU|Ensembl=ENSTRUG00000007465|UniProtKB=H2T1E8	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF291	ADP-RIBOSYLATION FACTOR 1
P00059	p53 pathway	P04630	PP2A	MACMU|Ensembl=ENSMMUG00000020819|UniProtKB=F7HSM1	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00643	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01451	Galpha	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	IDA	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P02738	De novo purine biosynthesis	P02909	GDP reductase	ANOGA|EnsemblGenome=AGAP006818|UniProtKB=Q7QIF4	AGAP006818-PA	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	10540223	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000019277|UniProtKB=H2QUQ1	Uncharacterized protein	ISS	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00005	Angiogenesis	P00255	Notch	BOVIN|Ensembl=ENSBTAG00000007909|UniProtKB=F1MPE9	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=12786|UniProtKB=O00755	Protein Wnt-7a	IDA	12549854	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00023	General transcription regulation	P00666	TFIIE	PANTR|Ensembl=ENSPTRG00000015273|UniProtKB=H2QN66	General transcription factor IIE, polypeptide 1, alpha 56kDa	ISS	92065982	PubMed	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00018	EGF receptor signaling pathway	P00552	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00057	Wnt signaling pathway	P01448	CBP	PANTR|Ensembl=ENSPTRG00000014418|UniProtKB=H2QLS0	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00021	FGF signaling pathway	P00633	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00019	Endothelin signaling pathway	P00572	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01238	14-3-3	DANRE|ZFIN=ZDB-GENE-030131-779|UniProtKB=Q7ZW20	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1	ISS	12917326	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00054	Toll receptor signaling pathway	P01375	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00034	Integrin signalling pathway	P00916	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	RAT|RGD=2025|UniProtKB=P68136	Actin, alpha skeletal muscle	ISS	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00018	EGF receptor signaling pathway	P00560	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=4599|UniProtKB=Q14831	Metabotropic glutamate receptor 7	IDA	9407094	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00059	p53 pathway	P04633	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01023	CaMKII	RAT|RGD=2262|UniProtKB=P08413	Calcium/calmodulin-dependent protein kinase type II subunit beta	ISS	12888804	PubMed	PTHR43940:SF3	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT BETA
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	MOUSE|MGI=MGI=104755|UniProtKB=P48545	G protein-activated inward rectifier potassium channel 4	IDA			PTHR11767:SF52	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 4
P00021	FGF signaling pathway	P00627	ERK1-2	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00066	DOPA decarb.	MACMU|Ensembl=ENSMMUG00000019991|UniProtKB=F7FNW0	Aromatic-L-amino-acid decarboxylase	ISS	90339966	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00019	Endothelin signaling pathway	P00586	Gq	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TRIVA|Gene=TVAG_512800|UniProtKB=A2HNG1	Actin (Fragment)	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00925	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02772	Pyruvate metabolism	P03140	Pyruvate Carboxylase	MACMU|Ensembl=ENSMMUG00000004533|UniProtKB=F6SC45	Pyruvate carboxylase	ISS	200246	gi	PTHR43778:SF2	PYRUVATE CARBOXYLASE, MITOCHONDRIAL
P00053	T cell activation	P01300	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	G04715	CYCLIN G	BOVIN|Ensembl=ENSBTAG00000006607|UniProtKB=Q5E9I1	Cyclin-G1	ISS	7957050	PubMed	PTHR10177:SF59	CYCLIN-G1
P00021	FGF signaling pathway	P00623	FGF	PANTR|Ensembl=ENSPTRG00000004000|UniProtKB=H2Q4B4	Fibroblast growth factor	ISS	12163055	PubMed	PTHR11486:SF31	FIBROBLAST GROWTH FACTOR 4
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00048	PI3 kinase pathway	P01196	PDK1	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	15531926	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	ARATH|TAIR=AT2G20290|UniProtKB=F4IUG9	Myosin-13	IC			PTHR13140:SF256	MYOSIN-10-RELATED
P05915	Opioid proenkephalin pathway	P05991	Enkephalin	MACMU|Ensembl=ENSMMUG00000006775|UniProtKB=F7H3N8	Uncharacterized protein	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P04398	p53 pathway feedback loops 2	P04657	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05918	p38 MAPK pathway	P06042	4E-BP1	MACMU|Ensembl=ENSMMUG00000002342|UniProtKB=F7C5U8	Uncharacterized protein	ISS	12820960	PubMed	PTHR12669:SF14	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00474	Wnt	BOVIN|Ensembl=ENSBTAG00000020221|UniProtKB=E1BDG5	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P04393	Ras Pathway	P04558	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00012	Cadherin signaling pathway	P00466	EGFR	MONDO|Ensembl=ENSMODG00000015755|UniProtKB=F6ZSZ9	Uncharacterized protein (Fragment)	ISS	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04397	p53 pathway by glucose deprivation	P04636	S6K	MOUSE|MGI=MGI=1927343|UniProtKB=Q9Z1M4	Ribosomal protein S6 kinase beta-2	IDA	6755374	gi	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00055	Transcription regulation by bZIP transcription factor	P01398	TFIIEalpha	HUMAN|HGNC=4650|UniProtKB=P29083	General transcription factor IIE subunit 1	IGI	189962	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	HUMAN|HGNC=1401|UniProtKB=Q02641	Voltage-dependent L-type calcium channel subunit beta-1	IDA	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00049	Parkinson disease	P01230	Src kinase	MONDO|Ensembl=ENSMODG00000021477|UniProtKB=F7G374	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF90	TYROSINE-PROTEIN KINASE YES
P06664	Gonadotropin-releasing hormone receptor pathway	P06858	SKIL	HUMAN|HGNC=10897|UniProtKB=P12757	Ski-like protein	RCA	10485843	PubMed	PTHR10005:SF3	SKI-LIKE PROTEIN
P00057	Wnt signaling pathway	P01435	SWI/SNF	CANLF|Ensembl=ENSCAFG00000013136|UniProtKB=E2REF0	Uncharacterized protein	ISS	11532957	PubMed	PTHR12802:SF9	SWI/SNF COMPLEX SUBUNIT SMARCC1
P00029	Huntington disease	P00805	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00057	Wnt signaling pathway	P01446	Calcineurin	MACMU|Ensembl=ENSMMUG00000004599|UniProtKB=F6Q932	Serine/threonine-protein phosphatase	ISS	7532676	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	1504106	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P02729	Ascorbate degradation	P02849	L-xylulose kinase	CANLF|Ensembl=ENSCAFG00000005028|UniProtKB=F1PI40	Uncharacterized protein	ISS			PTHR10196:SF57	XYLULOSE KINASE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05916	Opioid prodynorphin pathway	P06002	G-protein	DAPPU|EnsemblGenome=DAPPUDRAFT_59367|UniProtKB=E9H7Z0	Guanine nucleotide-binding protein G(O) subunit alpha 1	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	MOUSE|MGI=MGI=3584516|UniProtKB=E9Q1T6	Protein Lrp3	ISS	11907044	PubMed	PTHR44062:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 3
P00053	T cell activation	P01336	Jnk	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000014976|UniProtKB=H2R892	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	PANTR|Ensembl=ENSPTRG00000020202|UniProtKB=H2QW34	Uncharacterized protein	ISS	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00059	p53 pathway	P04634	Cdc2	MOUSE|MGI=MGI=104772|UniProtKB=P97377	Cyclin-dependent kinase 2	ISS	1846803	PubMed	PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00034	Integrin signalling pathway	P00912	Arp2/3	MACMU|Ensembl=ENSMMUG00000001458|UniProtKB=F7BKH1	Uncharacterized protein	ISS	12473693	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00030	Hypoxia response via HIF activation	P00821	Prolyl Hydroxylase	BOVIN|Ensembl=ENSBTAG00000017996|UniProtKB=F1MX98	Uncharacterized protein	ISS	12912907	PubMed	PTHR12907:SF6	EGL NINE HOMOLOG 2
P00005	Angiogenesis	P00251	cPLA2	CHICK|Ensembl=ENSGALG00000005065|UniProtKB=P49147	Cytosolic phospholipase A2	ISS	94299545	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00018	EGF receptor signaling pathway	P00554	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	10982827	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00048	PI3 kinase pathway	P01188	Gbetagamma	BRAFL|Gene=BRAFLDRAFT_220697|UniProtKB=C3ZSF0	Putative uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00034	Integrin signalling pathway	P00916	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00019	Endothelin signaling pathway	P00586	Gq	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00015	Circadian clock system	P00501	Clock	MACMU|Ensembl=ENSMMUG00000001919|UniProtKB=F6TZT0	Uncharacterized protein	ISS	10198158	PubMed	PTHR23042:SF2	CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00057	Wnt signaling pathway	P01443	Phospholipase C	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	HUMAN|HGNC=4404|UniProtKB=P59768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IDA	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	P01438	PP2A	MOUSE|MGI=MGI=1321159|UniProtKB=P63330	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IC	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04398	p53 pathway feedback loops 2	P04665	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	BOVIN|Gene=PPP1CA|UniProtKB=Q3T0E7	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit	ISS	8392016	PubMed	PTHR11668:SF377	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-ALPHA CATALYTIC SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00018	EGF receptor signaling pathway	P00542	EGFR	PANTR|Ensembl=ENSPTRG00000009100|UniProtKB=H2QCV1	Receptor protein-tyrosine kinase	ISS	2575867	gi	PTHR24416:SF137	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05918	p38 MAPK pathway	P06023	MEF	RAT|RGD=621489|UniProtKB=O89038	Myocyte-specific enhancer factor 2D	ISS			PTHR11945:SF23	MYOCYTE-SPECIFIC ENHANCER FACTOR 2D
P00009	Axon guidance mediated by netrin	P00364	cdc42	DAPPU|EnsemblGenome=DAPPUDRAFT_306746|UniProtKB=E9GYE9	Putative uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00060	Ubiquitin proteasome pathway	P01491	E2	ORYSJ|EnsemblGenome=OS05G0460200|UniProtKB=Q6L508	Os05g0460200 protein	ISS			PTHR24067:SF3	UBIQUITIN-CONJUGATING ENZYME E2 G1
P00029	Huntington disease	P00779	TBP	HALSA|EnsemblGenome=AAC82822|UniProtKB=Q48325	TATA-box-binding protein B	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01078	VAChT	DROME|FlyBase=FBgn0270928|UniProtKB=O17444	Vesicular acetylcholine transporter	IC			PTHR23506:SF13	VESICULAR ACETYLCHOLINE TRANSPORTER
P00029	Huntington disease	P00786	ARF	MOUSE|MGI=MGI=99436|UniProtKB=P61211	ADP-ribosylation factor-like protein 1	IPI	12932731	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P00018	EGF receptor signaling pathway	P00560	Raf-1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	BOVIN|Ensembl=ENSBTAG00000047856|UniProtKB=G3MZE2	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00055	Transcription regulation by bZIP transcription factor	P01390	TFIIA complex	CAEEL|WormBase=WBGene00015150|UniProtKB=Q9BIB4	Transcription initiation factor IIA small chain homolog	ISS	95241493	PubMed	PTHR10966:SF2	TRANSCRIPTION INITIATION FACTOR IIA SMALL CHAIN HOMOLOG
P00021	FGF signaling pathway	P00636	FGFR1-4	MOUSE|MGI=MGI=95522|UniProtKB=P16092	Fibroblast growth factor receptor 1	IPI	1708247	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P05731	GABA-B receptor II signaling	P05752	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00054	Toll receptor signaling pathway	P01346	TLR	MOUSE|MGI=MGI=96824|UniProtKB=Q9QUK6	Toll-like receptor 4	ISS			PTHR44568:SF1	TOLL-LIKE RECEPTOR 4
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00924	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	HUMAN|HGNC=10434|UniProtKB=O75582	Ribosomal protein S6 kinase alpha-5	ISS	9687510	PubMed	PTHR24351:SF115	RIBOSOMAL PROTEIN S6 KINASE ALPHA-5
P00005	Angiogenesis	P00256	PLC-gamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00049	Parkinson disease	P01230	Src kinase	MACMU|Ensembl=ENSMMUG00000015267|UniProtKB=F7GRP2	Tyrosine-protein kinase	ISS	12665526	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	PANTR|Ensembl=ENSPTRG00000007605|UniProtKB=H2QAA6	Nucleoside diphosphate kinase	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P05730	Endogenous cannabinoid signaling	P05751	Galpha	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P02738	De novo purine biosynthesis	P02901	Adenosuccinate lyase	LEIMA|EnsemblGenome=LmjF.04.0460|UniProtKB=Q9U0T7	Adenylosuccinate lyase	ISS			PTHR43411:SF1	ADENYLOSUCCINATE LYASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	ISS	12787066	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00021	FGF signaling pathway	P00643	Raf-1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IGI	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	CANLF|Ensembl=ENSCAFG00000004119|UniProtKB=F1PQA5	Uncharacterized protein	ISS	600075	OMIM	PTHR10126:SF20	TATA-BOX-BINDING PROTEIN
P00012	Cadherin signaling pathway	P00467	alpha-catenin	BOVIN|Gene=CTNNA1|UniProtKB=Q3MHM6	Catenin alpha-1	ISS	1768802	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	YEAST|SGD=S000005600|UniProtKB=P06785	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00049	Parkinson disease	P01242	Casein kinase I	ARATH|TAIR=AT4G28860|UniProtKB=Q8LPI7	Protein CASEIN KINASE I-LIKE 4	IDA	11437445	PubMed	PTHR11909:SF97	PROTEIN CASEIN KINASE I-LIKE 3-RELATED
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=12784|UniProtKB=P41221	Protein Wnt-5a	IDA	11266476	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PANTR|Ensembl=ENSPTRG00000023373|UniProtKB=G2HHT2	Tubulin beta-2C chain	ISS	9454836	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04393	Ras Pathway	P04557	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00702	CPB	BOVIN|Gene=CREB1|UniProtKB=P27925	Cyclic AMP-responsive element-binding protein 1	ISS			PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00021	FGF signaling pathway	P00629	PP2A	PANTR|Ensembl=ENSPTRG00000006426|UniProtKB=H2Q8F8	Protein phosphatase 2, regulatory subunit B', epsilon isoform	ISS	8703017	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00018	EGF receptor signaling pathway	P00551	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	IGI	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02754	Methylcitrate cycle	P03028	Aconitase	MOUSE|MGI=MGI=1928268|UniProtKB=Q811J3	Iron-responsive element-binding protein 2	ISS			PTHR11670:SF31	IRON-RESPONSIVE ELEMENT-BINDING PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347740|UniProtKB=E9FXV8	Cytoplasmatic actin	ISS	11889126	PubMed	PTHR11937:SF277	SUBFAMILY NOT NAMED
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00048	PI3 kinase pathway	P01185	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000019277|UniProtKB=H2QUQ1	Uncharacterized protein	ISS	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P05916	Opioid prodynorphin pathway	P06002	G-protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	ISS	8170357	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00054	Toll receptor signaling pathway	P01357	MEKK1	MACMU|Ensembl=ENSMMUG00000012387|UniProtKB=F7EB20	Uncharacterized protein	ISS	12168099	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P04398	p53 pathway feedback loops 2	P04665	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MACMU|Ensembl=ENSMMUG00000010266|UniProtKB=F6PV18	Uncharacterized protein	ISS	14500986	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P06664	Gonadotropin-releasing hormone receptor pathway	P06777	NFAT	MOUSE|MGI=MGI=1920431|UniProtKB=Q8K120	Nuclear factor of activated T-cells, cytoplasmic 4	RCA	9462517	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00012	Cadherin signaling pathway	P00474	Wnt	BRAFL|Gene=BRAFLDRAFT_118160|UniProtKB=C3Z2P0	Protein Wnt	IDA	8717036	PubMed	PTHR12027:SF77	PROTEIN WNT-5
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00034	Integrin signalling pathway	P00947	Laminin	CANLF|Ensembl=ENSCAFG00000011744|UniProtKB=E2R4J1	Uncharacterized protein	ISS	2538453	PubMed	PTHR10574:SF36	LAMININ SUBUNIT BETA-2
P05916	Opioid prodynorphin pathway	P05999	provasopressin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MONDO|Ensembl=ENSMODG00000016960|UniProtKB=F6V5G0	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DANRE|ZFIN=ZDB-GENE-070112-342|UniProtKB=A1L271	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00036	Interleukin signaling pathway	P00981	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	TAS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TAKRU|Ensembl=ENSTRUG00000007989|UniProtKB=P68140	Actin, alpha skeletal muscle A	ISS	14684598	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00006	Apoptosis signaling pathway	P00269	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	RAT|RGD=1311928|UniProtKB=D3ZT83	Protein Slc1a7	ISS	94365697	PubMed	PTHR11958:SF22	EXCITATORY AMINO ACID TRANSPORTER 5
P05917	Opioid proopiomelanocortin pathway	P06008	ACTH	MOUSE|MGI=MGI=97742|UniProtKB=P01193	Pro-opiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00049	Parkinson disease	P01215	Syntaxin	MOUSE|MGI=MGI=1931027|UniProtKB=Q9ER00	Syntaxin-12	ISS	10321247	PubMed	PTHR19957:SF88	SYNTAXIN-12
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=104692|UniProtKB=F7BJK1	Protein Pcdh1 (Fragment)	ISS	8120095	PubMed	PTHR43912:SF3	PROTOCADHERIN-1
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01439	C-terminal Binding Protein	MOUSE|MGI=MGI=1201686|UniProtKB=P56546	C-terminal-binding protein 2	ISS	10375506	PubMed	PTHR10996:SF72	C-TERMINAL-BINDING PROTEIN 2
P00008	Axon guidance mediated by Slit/Robo	P00351	Cxcr4	MACMU|Gene=CXCR4|UniProtKB=P79394	C-X-C chemokine receptor type 4	ISS	11943720	PubMed	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00018	EGF receptor signaling pathway	P00540	MKK3,6	MOUSE|MGI=MGI=1346868|UniProtKB=O09110	Dual specificity mitogen-activated protein kinase kinase 3	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P02744	Fructose galactose metabolism	P02964	Hexose 1-P uridyltransferase	CANLF|Ensembl=ENSCAFG00000001946|UniProtKB=E2RB65	Galactose-1-phosphate uridylyltransferase	ISS	1427861	PubMed	PTHR11943:SF1	GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	CHICK|Ensembl=ENSGALG00000011905|UniProtKB=F1NHT7	Uncharacterized protein	TAS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00012	Cadherin signaling pathway	P00470	F-actin	MACMU|Ensembl=ENSMMUG00000017683|UniProtKB=F6UA63	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	RAT|RGD=619747|UniProtKB=O70257	Syntaxin-7	IC	14570579	PubMed	PTHR19957:SF90	SYNTAXIN-7
P00014	Cholesterol biosynthesis	P00496	Diphosphomevalonate decarboxylase	ARATH|TAIR=AT3G54250|UniProtKB=F4JCU3	Diphosphomevalonate decarboxylase MVD2	ISS	4505289	gi	PTHR10977:SF3	DIPHOSPHOMEVALONATE DECARBOXYLASE
P00005	Angiogenesis	P00206	Wnt	DROME|FlyBase=FBgn0010194|UniProtKB=P28466	Protein Wnt-5	ISS	11266476	PubMed	PTHR12027:SF77	PROTEIN WNT-5
P00046	Oxidative stress response	P01131	MKP5	MOUSE|MGI=MGI=1915332|UniProtKB=Q8K4T5	Dual specificity protein phosphatase 19	TAS			PTHR10159:SF402	DUAL SPECIFICITY PROTEIN PHOSPHATASE 19
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00589	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MACMU|Ensembl=ENSMMUG00000009980|UniProtKB=F6R3A1	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	IDA	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00384	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04398	p53 pathway feedback loops 2	P04661	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	ISS	8700226	PubMed	PTHR10048:SF14	PI-3 KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00029	Huntington disease	P00777	CBP	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00047	PDGF signaling pathway	P01159	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	XENTR|GeneID=394982|UniProtKB=P20399	Actin, alpha cardiac muscle 2	ISS	10974003	PubMed	PTHR11937:SF263	ACTIN
P02738	De novo purine biosynthesis	P02905	Amidophosphoribosyl transferase	ARATH|TAIR=AT4G34740|UniProtKB=Q9STG9	Amidophosphoribosyltransferase 2, chloroplastic	ISS			PTHR11907:SF0	AMIDOPHOSPHORIBOSYLTRANSFERASE
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	HUMAN|HGNC=4341|UniProtKB=P15104	Glutamine synthetase	ISS			PTHR20852:SF45	GLUTAMINE SYNTHETASE
P04397	p53 pathway by glucose deprivation	P04641	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00219	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P02741	Flavin biosynthesis	P02933	Pyrimidine deaminase	ARATH|TAIR=AT4G20960|UniProtKB=Q8GWP5	Riboflavin biosynthesis protein PYRD, chloroplastic	ISS			PTHR45091:SF2	RIBOFLAVIN BIOSYNTHESIS PROTEIN PYRD, CHLOROPLASTIC
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00059	p53 pathway	P04609	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01165	SRF	CANLF|Ensembl=ENSCAFG00000001829|UniProtKB=F1PH12	Uncharacterized protein	ISS	15170389	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	HUMAN|HGNC=4404|UniProtKB=P59768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00011	Blood coagulation	P00421	alpha1-antitrypsin	PANTR|Ensembl=ENSPTRG00000023666|UniProtKB=H2R1G9	Uncharacterized protein	ISS	2116650	gi	PTHR11461:SF165	ALPHA-1-ANTITRYPSIN-RELATED
P00010	B cell activation	P00379	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	MACMU|Ensembl=ENSMMUG00000017022|UniProtKB=F7HQZ9	Uncharacterized protein	ISS	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000018051|UniProtKB=F7ER09	Uncharacterized protein	ISS	8120095	PubMed	PTHR24026:SF42	PROTOCADHERIN FAT 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00052	TGF-beta signaling pathway	P01276	Co-Smads	BOVIN|Gene=SMAD4|UniProtKB=Q1HE26	Mothers against decapentaplegic homolog 4	ISS	10693808	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P00006	Apoptosis signaling pathway	P00272	ASK1	MOUSE|MGI=MGI=1346876|UniProtKB=O35099	Mitogen-activated protein kinase kinase kinase 5	ISS	12697749	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00038	JAK/STAT signaling pathway	P01027	STAT	HUMAN|HGNC=11364|UniProtKB=P40763	Signal transducer and activator of transcription 3	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04392	P53 pathway feedback loops 1	P04537	p73DeltaN	MACMU|Ensembl=ENSMMUG00000016466|UniProtKB=F7GBH1	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00030	Hypoxia response via HIF activation	P00823	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	14526383	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00049	Parkinson disease	P01238	14-3-3	CHICK|Ensembl=ENSGALG00000010725|UniProtKB=Q5ZKC9	14-3-3 protein zeta	ISS	12615066	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00005	Angiogenesis	P00223	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00006	Apoptosis signaling pathway	P00258	Bik	MOUSE|MGI=MGI=1206591|UniProtKB=O70337	Bcl-2-interacting killer	IDA	11714762	PubMed	PTHR15018:SF1	BCL-2-INTERACTING KILLER
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00060	Ubiquitin proteasome pathway	P01490	E3	CHICK|Ensembl=ENSGALG00000006461|UniProtKB=F1NZJ6	Uncharacterized protein	ISS			PTHR11254:SF357	UBIQUITIN-PROTEIN LIGASE E3C
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	CAEEL|WormBase=WBGene00001603|UniProtKB=P34497	Probable glutamine synthetase	ISS			PTHR20852:SF57	GLUTAMINE SYNTHETASE 2 CYTOPLASMIC
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02743	Formyltetrahydroformate biosynthesis	P02958	Dihydrofolate synthase	THEMA|EnsemblGenome=TM_0166|UniProtKB=Q9WY13	Folylpolyglutamate synthase/dihydrofolate synthase	ISS			PTHR11136:SF0	DIHYDROFOLATE SYNTHETASE-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00001	Adrenaline and noradrenaline biosynthesis	P00065	DAT	MOUSE|MGI=MGI=94862|UniProtKB=Q61327	Sodium-dependent dopamine transporter	ISS	15135042	PubMed	PTHR11616:SF38	SODIUM-DEPENDENT DOPAMINE TRANSPORTER
P05730	Endogenous cannabinoid signaling	P05751	Galpha	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00053	T cell activation	P01332	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	IDA	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	88234494	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	CAEEL|WormBase=WBGene00007974|UniProtKB=Q93341	Putative dihydrofolate reductase	ISS			PTHR22778:SF16	DIHYDROFOLATE REDUCTASE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	HUMAN|HGNC=4232|UniProtKB=P39905	Glial cell line-derived neurotrophic factor	TAS	9759503	PubMed	PTHR12173:SF1	GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00002	Alpha adrenergic receptor signaling pathway	P00078	Alpha1A/1B/1C	MACMU|Ensembl=ENSMMUG00000005691|UniProtKB=F6U596	Uncharacterized protein	ISS	6323229	PubMed	PTHR24248:SF17	ALPHA-1B ADRENERGIC RECEPTOR
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	TAS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	AQUAE|EnsemblGenome=aq_410|UniProtKB=O66727	Carbamoyl-phosphate synthase small chain	ISS			PTHR11405:SF4	CARBAMOYL-PHOSPHATE SYNTHASE ARGININE-SPECIFIC SMALL CHAIN
P00010	B cell activation	P00373	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IGI	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04396	Vitamin D metabolism and pathway	P04602	RXR	RAT|RGD=3610|UniProtKB=Q05343	Retinoic acid receptor RXR-alpha	RCA			PTHR24083:SF39	RETINOIC ACID RECEPTOR RXR-ALPHA
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02787	Vitamin B6 metabolism	P03227	Phosphoserine transaminase	BOVIN|Ensembl=ENSBTAG00000013960|UniProtKB=A6QR28	Phosphoserine aminotransferase	ISS	2682527	PubMed	PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	22533439	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P04393	Ras Pathway	P04574	PLD	CANAL|CGD=CAL0002069|UniProtKB=Q59TT3	Uncharacterized protein	ISS			PTHR18896:SF113	PHOSPHOLIPASE D1
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00018	EGF receptor signaling pathway	P00539	14-3-3	PANTR|Ensembl=ENSPTRG00000030723|UniProtKB=H2RC87	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF14	14-3-3 PROTEIN SIGMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	TAS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	RCA	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00018	EGF receptor signaling pathway	P00551	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IGI	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00019	Endothelin signaling pathway	P00591	PLCbeta	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05730	Endogenous cannabinoid signaling	P05748	mGluR	CHICK|Ensembl=ENSGALG00000017238|UniProtKB=F1NWG3	Uncharacterized protein	ISS	8314195	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05924	AT1-R	RAT|RGD=2070|UniProtKB=P25095	Type-1A angiotensin II receptor	RCA			PTHR24228:SF11	TYPE-1 ANGIOTENSIN II RECEPTOR
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04665	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01154	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00004	Alzheimer disease-presenilin pathway	P00170	Aph-1	DROME|FlyBase=FBgn0031458|UniProtKB=Q9VQG2	Gamma-secretase subunit Aph-1	IDA	12110170	PubMed	PTHR12889:SF0	GAMMA-SECRETASE SUBUNIT APH-1
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04395	Vasopressin synthesis	P04597	Signal Peptide	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Ensembl=ENSCAFG00000000332|UniProtKB=F1P8E3	Uncharacterized protein	ISS	11431030	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00048	PI3 kinase pathway	P01192	p110	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00056	VEGF signaling pathway	P01417	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	RAT|RGD=69319|UniProtKB=P54313	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	HUMAN|HGNC=6551|UniProtKB=Q9UJU2	Lymphoid enhancer-binding factor 1	TAS	11266476	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00034	Integrin signalling pathway	P00944	Actin	BOVIN|Gene=ACTG2|UniProtKB=Q5E9B5	Actin, gamma-enteric smooth muscle	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P02774	Salvage pyrimidine deoxyribonucleotides	P03146	Deoxyuridine kinase	DICDI|dictyBase=DDB_G0289179|UniProtKB=Q27564	Thymidine kinase 1	ISS			PTHR11441:SF0	THYMIDINE KINASE, CYTOSOLIC
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	CANLF|Ensembl=ENSCAFG00000004956|UniProtKB=E2REH3	Uncharacterized protein	ISS	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P05734	Synaptic vesicle trafficking	P05778	SNAP-25	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	TAS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MOUSE|MGI=MGI=99673|UniProtKB=P84309	Adenylate cyclase type 5	ISS	93156838	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00035	Interferon-gamma signaling pathway	P00960	PTP	MONDO|Ensembl=ENSMODG00000003120|UniProtKB=F6WVD2	Tyrosine-protein phosphatase non-receptor type	ISS	7681589	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	CANLF|Ensembl=ENSCAFG00000000828|UniProtKB=F6UWI0	Ribosomal protein S6 kinase	ISS	1922062	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00036	Interleukin signaling pathway	P00996	STAT	CANLF|Ensembl=ENSCAFG00000015346|UniProtKB=E2RE22	Signal transducer and activator of transcription	ISS	8584036	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	PANTR|Ensembl=ENSPTRG00000001767|UniProtKB=G2HG81	Actin-related protein 2/3 complex subunit 5	ISS	12932731	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	MACMU|Ensembl=ENSMMUG00000006202|UniProtKB=F7HNP4	Excitatory amino acid transporter 1 isoform 1	ISS	96032356	PubMed	PTHR11958:SF24	EXCITATORY AMINO ACID TRANSPORTER 1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00005	Angiogenesis	P00219	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00053	T cell activation	P01322	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00057	Wnt signaling pathway	P01458	Protein Kinase C	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	IDA	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00005	Angiogenesis	P00244	MAPKAPK2/3	RAT|RGD=1304980|UniProtKB=Q66H84	MAP kinase-activated protein kinase 3	ISS	11157753	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P00008	Axon guidance mediated by Slit/Robo	P00355	Rho	CAEBR|Gene=CBG13664|UniProtKB=A8XIF5	Protein CBR-RHO-1	ISS	11973360	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00774	Dynein complex	USTMA|Gene=UMAG_04372|UniProtKB=A0A0D1DSG8	Chromosome 14, whole genome shotgun sequence	IPI	9454836	PubMed	PTHR10676:SF314	CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1
P04395	Vasopressin synthesis	P04593	Glycopeptide	MACMU|Ensembl=ENSMMUG00000010678|UniProtKB=F7AXI7	Uncharacterized protein	ISS	192340	OMIM	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P04393	Ras Pathway	P04542	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	TAS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00059	p53 pathway	G01574	ARF	MOUSE|MGI=MGI=105387|UniProtKB=Q60773	Cyclin-dependent kinase 4 inhibitor D	ISS			PTHR24148:SF47	CYCLIN-DEPENDENT KINASE 4 INHIBITOR B-RELATED
P00056	VEGF signaling pathway	P01414	PLC-gamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00018	EGF receptor signaling pathway	P00547	PP2A	RAT|RGD=1585097|UniProtKB=A0A0G2JZD1	Protein Ppp2r5c	ISS	8576224	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	ARATH|TAIR=AT5G58950|UniProtKB=Q9FIL6	At5g58950	ISS			PTHR44581:SF2	PROTEIN KINASE 6-LIKE PROTEIN
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	IDA	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IDA	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00029	Huntington disease	P00786	ARF	CAEEL|WormBase=WBGene00000182|UniProtKB=Q10943	ADP-ribosylation factor 1-like 2	IPI	12932731	PubMed	PTHR11711:SF304	ADP-RIBOSYLATION FACTOR 1
P05731	GABA-B receptor II signaling	P05754	Ggamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	TAS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05961	DOPA decarb.	CAEEL|WormBase=WBGene00000239|UniProtKB=O45137	Biogenic Amine Synthesis related	ISS	90339966	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00021	FGF signaling pathway	P00627	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	97449291	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05734	Synaptic vesicle trafficking	P05773	Munc13	HUMAN|HGNC=23149|UniProtKB=Q8NB66	Protein unc-13 homolog C	ISS	605836	OMIM	PTHR10480:SF2	PROTEIN UNC-13 HOMOLOG C
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000024992|UniProtKB=F6TUR3	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00006	Apoptosis signaling pathway	P00313	IKK	PANTR|Ensembl=ENSPTRG00000033948|UniProtKB=H2RBD4	Conserved helix-loop-helix ubiquitous kinase	ISS	12235208	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P02748	Isoleucine biosynthesis	P02995	Threonine dehydratase	SCHPO|PomBase=SPCC320.14|UniProtKB=O59791	Serine racemase	ISS			PTHR43050:SF1	SERINE RACEMASE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	TAS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	21157398	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00017	DNA replication	P00531	Pol alpha	PLAF7|EnsemblGenome=PFD0590c|UniProtKB=Q9U0H1	DNA polymerase	ISS	93376482	PubMed	PTHR10322:SF21	DNA POLYMERASE ALPHA CATALYTIC SUBUNIT
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	MACMU|Ensembl=ENSMMUG00000012033|UniProtKB=F7GWI2	Serine/threonine-protein kinase PAK 2	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	MONDO|Ensembl=ENSMODG00000018237|UniProtKB=F6PG65	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02920	dCTP deaminase	STRCO|Gene=CAC32309|UniProtKB=Q9AK79	tRNA-specific adenosine deaminase	ISS			PTHR11079:SF149	TRNA-SPECIFIC ADENOSINE DEAMINASE
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00046	Oxidative stress response	P01134	cPLA2	RAT|RGD=67366|UniProtKB=P50393	Cytosolic phospholipase A2	TAS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P05731	GABA-B receptor II signaling	P05760	AC	BOVIN|Ensembl=ENSBTAG00000005464|UniProtKB=E1B9K3	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00019	Endothelin signaling pathway	P00586	Gq	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00005	Angiogenesis	P00190	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00211	GSK3beta	CIOIN|Ensembl=ENSCING00000001821|UniProtKB=Q9NL43	Glycogen synthase kinase	ISS			PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CANLF|Ensembl=ENSCAFG00000002617|UniProtKB=E2QUL1	Uncharacterized protein	ISS	11554554	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P02748	Isoleucine biosynthesis	P02996	Ketol-acid reductoisomerase	BACTN|EnsemblGenome=BT_2074|UniProtKB=Q8A612	Ketol-acid reductoisomerase (NADP(+))	ISS			PTHR21371:SF1	KETOL-ACID REDUCTOISOMERASE, CHLOROPLASTIC
P00046	Oxidative stress response	P01129	JNK1/2	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00009	Axon guidance mediated by netrin	P00363	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	ISS	96320556	PubMed	PTHR10048:SF14	PI-3 KINASE
P00029	Huntington disease	P00778	NMDA receptor	DROME|FlyBase=FBgn0010399|UniProtKB=Q24418	Glutamate [NMDA] receptor subunit 1	IDA	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=621089|UniProtKB=F1LMI3	Cadherin 3, type 1, P-cadherin (Placental)	ISS	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04665	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04623	CBP	CAEEL|WormBase=WBGene00009595|UniProtKB=Q7JMS5	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00006	Apoptosis signaling pathway	P00269	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00629	PP2A	MONDO|Ensembl=ENSMODG00000014177|UniProtKB=F6U7A6	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00589	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IGI	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	PANTR|Ensembl=ENSPTRG00000004701|UniProtKB=H2Q5G9	Low density lipoprotein receptor-related protein 6	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00012	Cadherin signaling pathway	P00475	Frizzled	BOVIN|Ensembl=ENSBTAG00000035084|UniProtKB=F1MLG5	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF22	FRIZZLED-3
P00057	Wnt signaling pathway	P01443	Phospholipase C	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00036	Interleukin signaling pathway	P00981	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00006	Apoptosis signaling pathway	P00313	IKK	MOUSE|MGI=MGI=99484|UniProtKB=Q60680	Inhibitor of nuclear factor kappa-B kinase subunit alpha	ISS	12813046	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00030	Hypoxia response via HIF activation	P00819	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	TAS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00053	T cell activation	P01332	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000010392|UniProtKB=F7ASR8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00029	Huntington disease	P00770	N-CoR	CANLF|Ensembl=ENSCAFG00000006985|UniProtKB=F1PQQ7	Uncharacterized protein	ISS	10441327	PubMed	PTHR13992:SF21	NUCLEAR RECEPTOR COREPRESSOR 2
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	XENTR|Xenbase=XB-GENE-992519|UniProtKB=F6VS22	Uncharacterized protein	ISS	9700720	PubMed	PTHR43893:SF8	D 1B  DOPAMINE RECEPTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00011	Blood coagulation	P00458	GP IIIa	HUMAN|Ensembl=ENSG00000259753|UniProtKB=H3BM21	Integrin beta (Fragment)	ISS	5805343	gi	PTHR10082:SF25	INTEGRIN BETA-3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00018	EGF receptor signaling pathway	P00551	Akt	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	IGI	12655147	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06785	ELK1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	RCA	9644975	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05913	Enkephalin release	P05974	G-Protein (i)	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	IC	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TRIVA|Gene=TVAG_090470|UniProtKB=A2FA04	Actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000012778|UniProtKB=H2QJ75	Phosphoinositide phospholipase C	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P00048	PI3 kinase pathway	P01194	S6K	XENTR|Xenbase=XB-GENE-482409|UniProtKB=F6UK84	Uncharacterized protein (Fragment)	ISS	11861821	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00018	EGF receptor signaling pathway	P00564	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00015	Circadian clock system	P00505	Cry	BOVIN|Ensembl=ENSBTAG00000021223|UniProtKB=F1N0J9	Uncharacterized protein	ISS	10428031	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	PANTR|Ensembl=ENSPTRG00000019161|UniProtKB=H2QUJ4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=1306541|UniProtKB=D3ZVF3	Phosphoinositide-3-kinase, class 2, beta polypeptide (Predicted)	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00021	FGF signaling pathway	P00636	FGFR1-4	MOUSE|MGI=MGI=95524|UniProtKB=Q61851	Fibroblast growth factor receptor 3	IPI	94209351	PubMed	PTHR24416:SF505	FIBROBLAST GROWTH FACTOR RECEPTOR 3
P04397	p53 pathway by glucose deprivation	P04639	AMPK	MONDO|Ensembl=ENSMODG00000015269|UniProtKB=F6TML6	Uncharacterized protein	ISS			PTHR10343:SF16	5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	DROME|FlyBase=FBgn0263116|UniProtKB=P28286	5-hydroxytryptamine receptor 2B	ISS	12181435	PubMed	PTHR24247:SF117	5-HYDROXYTRYPTAMINE RECEPTOR 2A-RELATED
P00029	Huntington disease	P00790	beta-Tubulin	IXOSC|EnsemblGenome=ISCW017133|UniProtKB=B7PA92	Beta tubulin	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00053	T cell activation	P01305	Calmodulin	MONDO|Ensembl=ENSMODG00000004410|UniProtKB=F6SV58	Uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF322	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01444	Wnt	TAKRU|Ensembl=ENSTRUG00000016522|UniProtKB=H2UZ46	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00985	PDK1/2	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	IDA	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	MOUSE|MGI=MGI=88296|UniProtKB=O55017	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	8386525	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-040718-93|UniProtKB=Q6DGZ5	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MONDO|Ensembl=ENSMODG00000020204|UniProtKB=F6SED9	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00786	ARF	ORYSJ|EnsemblGenome=OS05G0489600|UniProtKB=P51823	ADP-ribosylation factor 2	ISS	12932731	PubMed	PTHR11711:SF232	ADP-RIBOSYLATION FACTOR A1E
P00048	PI3 kinase pathway	P01188	Gbetagamma	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00018	EGF receptor signaling pathway	P00551	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	RAT|RGD=2746|UniProtKB=P31424	Metabotropic glutamate receptor 5	ISS	7476890	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00012	Cadherin signaling pathway	P00467	alpha-catenin	MACMU|Ensembl=ENSMMUG00000000293|UniProtKB=F6YFG3	Uncharacterized protein	ISS	1638632	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P00054	Toll receptor signaling pathway	P01338	IkappaB	RAT|RGD=3171|UniProtKB=Q63746	NF-kappa-B inhibitor alpha	ISS	12637573	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	RAT|RGD=71027|UniProtKB=P42264	Glutamate receptor ionotropic, kainate 3	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IDA	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01457	GBeta	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IDA	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IDA	176910	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	ORNAN|Ensembl=ENSOANG00000006811|UniProtKB=F6WBD5	Uncharacterized protein	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P00008	Axon guidance mediated by Slit/Robo	P00344	Netrin	MACMU|Ensembl=ENSMMUG00000000521|UniProtKB=F7A403	Netrin-4	ISS	2538453	PubMed	PTHR10574:SF282	NETRIN-4
P05913	Enkephalin release	P05972	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00947	Laminin	CANLF|Ensembl=ENSCAFG00000004043|UniProtKB=F1PR66	Uncharacterized protein	ISS	2538453	PubMed	PTHR44537:SF1	LAMININ SUBUNIT ALPHA-4
P00034	Integrin signalling pathway	P00938	Cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	RCA	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CAEEL|WormBase=WBGene00000063|UniProtKB=P0DM41	Actin-1	IC	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00056	VEGF signaling pathway	P01417	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00053	T cell activation	P01332	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IDA	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00036	Interleukin signaling pathway	P00981	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	BOVIN|Ensembl=ENSBTAG00000018253|UniProtKB=P02709	Acetylcholine receptor subunit alpha	ISS	85270494	PubMed	PTHR18945:SF74	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA
P05918	p38 MAPK pathway	P06013	ELK	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	10487205	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	IC	8838325	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00029	Huntington disease	P00804	Synaptojanin	CAEEL|WormBase=WBGene00006763|UniProtKB=G5ECL2	Synaptojanin UNC-26A	IDA			PTHR11200:SF256	GH06496P
P00018	EGF receptor signaling pathway	P00557	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00053	T cell activation	P01307	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	RAT|RGD=1310749|UniProtKB=D3Z9H7	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	ISS	12015605	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00005	Angiogenesis	P00211	GSK3beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00029	Huntington disease	P00774	Dynein complex	TRIAD|EnsemblGenome=TriadG19810|UniProtKB=B3RJW0	Neuronal nitric oxidse synthase protein inhibitor	ISS	9454836	PubMed	PTHR11886:SF62	DYNEIN, LIGHT CHAIN, LC8-TYPE 2
P00029	Huntington disease	P00790	beta-Tubulin	DICPU|Gene=DICPUDRAFT_47166|UniProtKB=F0ZI20	Beta tubulin	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01465	Ggamma	MACMU|Ensembl=ENSMMUG00000000846|UniProtKB=F6Q1E0	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR15936:SF2	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-13
P02788	Xanthine and guanine salvage pathway	P03248	Deoxyguanosine phosphorylase	THEMA|EnsemblGenome=TM_1596|UniProtKB=Q9X1T2	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00029	Huntington disease	P00774	Dynein complex	CHICK|Ensembl=ENSGALG00000011330|UniProtKB=F1NKL4	Uncharacterized protein	ISS	9454836	PubMed	PTHR10676:SF314	CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=18231|UniProtKB=Q9BYE9	Cadherin-related family member 2	IDA	8120095	PubMed	PTHR44787:SF1	CADHERIN-RELATED FAMILY MEMBER 2
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	RAT|RGD=620314|UniProtKB=B0LPN4	Ryanodine receptor 2	ISS	15226293	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	1333286	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00029	Huntington disease	P00782	alpha-Adaptin	MONDO|Ensembl=ENSMODG00000013428|UniProtKB=F7C503	Uncharacterized protein (Fragment)	ISS	11532990	PubMed	PTHR22780:SF19	AP-2 COMPLEX SUBUNIT ALPHA-1
P00048	PI3 kinase pathway	P01177	P110ACT	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00053	T cell activation	P01306	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	87226391	PubMed	PTHR24070:SF385	GTPASE HRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	IDA	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	TAS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	IDA	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00036	Interleukin signaling pathway	P00983	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00029	Huntington disease	P00761	Truncated Htt	MACMU|Ensembl=ENSMMUG00000008392|UniProtKB=F6VQZ3	Uncharacterized protein	ISS	7620118	PubMed	PTHR10170:SF10	HUNTINGTIN
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	MOUSE|MGI=MGI=97364|UniProtKB=O35516	Neurogenic locus notch homolog protein 2	IDA	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00047	PDGF signaling pathway	P01174	Rho	HUMAN|HGNC=16348|UniProtKB=Q8IWW6	Rho GTPase-activating protein 12	ISS			PTHR23181:SF3	RHO GTPASE-ACTIVATING PROTEIN 12
P00057	Wnt signaling pathway	P01444	Wnt	CANLF|Ensembl=ENSCAFG00000008760|UniProtKB=E2RTG8	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00015	Circadian clock system	G01501	cry	HUMAN|HGNC=2385|UniProtKB=Q49AN0	Cryptochrome-2	IEP	14507900	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05918	p38 MAPK pathway	P06028	MLK2	RAT|RGD=1308381|UniProtKB=D3ZG83	Protein Map3k10	ISS	9639556	PubMed	PTHR43997:SF5	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 10
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	15531926	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00018	EGF receptor signaling pathway	P00549	EGF	HUMAN|HGNC=7997|UniProtKB=Q02297	Pro-neuregulin-1, membrane-bound isoform	RCA			PTHR11100:SF7	PRO-NEUREGULIN-1, MEMBRANE-BOUND ISOFORM
P00018	EGF receptor signaling pathway	P00562	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00009	Axon guidance mediated by netrin	P00364	cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P02783	Tryptophan biosynthesis	P03209	Anthranilate phosphoribosyl transferase	ARATH|TAIR=AT5G17990|UniProtKB=Q02166	Anthranilate phosphoribosyltransferase, chloroplastic	ISS			PTHR43285:SF2	ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE
P05731	GABA-B receptor II signaling	P05754	Ggamma	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CAEEL|WormBase=WBGene00002348|UniProtKB=P02567	Myosin-1	IC			PTHR13140:SF555	MYOSIN HEAVY CHAIN, MUSCLE
P02763	Peptidoglycan biosynthesis	P03083	UDP-N-acetylmuramoylalanine-D-glutamate ligase	CHLTR|EnsemblGenome=CT_758|UniProtKB=O84763	UDP-N-acetylmuramoylalanine--D-glutamate ligase	ISS			PTHR43692:SF1	UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CANLF|Ensembl=ENSCAFG00000005662|UniProtKB=E2R907	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MACMU|Ensembl=ENSMMUG00000015065|UniProtKB=F6WWD4	Uncharacterized protein	ISS			PTHR44152:SF1	HISTAMINE H4 RECEPTOR
P04393	Ras Pathway	P04542	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00029	Huntington disease	P00807	Actin	HUMAN|HGNC=144|UniProtKB=P63261	Actin, cytoplasmic 2	IDA	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00018	EGF receptor signaling pathway	P00552	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P02783	Tryptophan biosynthesis	P03207	Tryptophan synthase A	CHLTR|EnsemblGenome=CT_171|UniProtKB=O84173	Tryptophan synthase alpha chain	ISS			PTHR43455:SF1	SUBFAMILY NOT NAMED
P00016	Cytoskeletal regulation by Rho GTPase	P00510	mDia	RAT|RGD=1593287|UniProtKB=F1LVW7	Protein Diaph3	ISS			PTHR23213:SF198	PROTEIN DIAPHANOUS HOMOLOG 3
P05916	Opioid prodynorphin pathway	P06001	AC	MOUSE|MGI=MGI=102891|UniProtKB=P51829	Adenylate cyclase type 7	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00019	Endothelin signaling pathway	P00566	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	ORYSJ|EnsemblGenome=OS09G0534800|UniProtKB=Q8W0W3	Transcription initiation factor IIB	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	HUMAN|HGNC=7574|UniProtKB=Q9Y623	Myosin-4	ISS	89264452	PubMed	PTHR13140:SF681	MYOSIN-4
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	ANOGA|EnsemblGenome=AGAP006521|UniProtKB=Q7Q5C3	AGAP006521-PA	ISS			PTHR10218:SF229	GUANINE NUCLEOTIDE-BINDING PROTEIN G F  SUBUNIT ALPHA
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	TAS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00029	Huntington disease	P00778	NMDA receptor	DANRE|ZFIN=ZDB-GENE-051202-1|UniProtKB=E7F101	Uncharacterized protein	ISS	92049750	PubMed	PTHR44391:SF2	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	PANTR|Ensembl=ENSPTRG00000012613|UniProtKB=H2QIY0	Uncharacterized protein	ISS	11907044	PubMed	PTHR44025:SF5	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01443	Phospholipase C	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	MOUSE|MGI=MGI=1351338|UniProtKB=P97772	Metabotropic glutamate receptor 1	ISS			PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00037	Ionotropic glutamate receptor pathway	P01018	Glu1	TAKRU|Ensembl=ENSTRUG00000005608|UniProtKB=H2SM93	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P05913	Enkephalin release	P05977	G-Protein (s)	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00010	B cell activation	P00385	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	MOUSE|MGI=MGI=97364|UniProtKB=O35516	Neurogenic locus notch homolog protein 2	IDA	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00049	Parkinson disease	P01242	Casein kinase I	ARATH|TAIR=AT4G28540|UniProtKB=Q8LPJ1	Casein kinase 1-like protein 6	IDA	11437445	PubMed	PTHR11909:SF114	ADK1-RELATED
P00036	Interleukin signaling pathway	P00965	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00005	Angiogenesis	P00243	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00057	Wnt signaling pathway	P01440	Cadherin	MONDO|Ensembl=ENSMODG00000000011|UniProtKB=F6SJ04	Uncharacterized protein	ISS	8120095	PubMed	PTHR43912:SF5	PROTOCADHERIN-9
P00050	Plasminogen activating cascade	P01255	Plasminogen	MACMU|Gene=PLG|UniProtKB=P12545	Plasminogen	ISS	4505881	gi	PTHR24261:SF6	PLASMINOGEN
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05916	Opioid prodynorphin pathway	P06000	vasopressin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	RAT|RGD=3250|UniProtKB=P35465	Serine/threonine-protein kinase PAK 1	ISS	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IDA	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	CAEEL|WormBase=WBGene00000068|UniProtKB=Q19523	Adenylyl CYclase	IDA	2491850	PubMed	PTHR11920:SF319	ADENYLATE CYCLASE TYPE 9
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	IXOSC|EnsemblGenome=ISCW021810|UniProtKB=B7Q8S0	DNA-directed RNA polymerase	ISS			PTHR23431:SF3	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5
P00057	Wnt signaling pathway	P01465	Ggamma	MACMU|Ensembl=ENSMMUG00000014807|UniProtKB=F6W548	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00048	PI3 kinase pathway	P01192	p110	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00256	PLC-gamma	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P02756	N-acetylglucosamine metabolism	P03041	Glucosamine-6-phosphate deaminase	BACSU|EnsemblGenome=BSU02360|UniProtKB=O31458	Probable glucosamine-6-phosphate deaminase 2	ISS			PTHR11280:SF5	GLUCOSAMINE-6-PHOSPHATE ISOMERASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	HUMAN|HGNC=708|UniProtKB=O15511	Actin-related protein 2/3 complex subunit 5	IDA	12932731	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MACMU|Ensembl=ENSMMUG00000011466|UniProtKB=F7B2R8	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	ARATH|TAIR=AT3G45640|UniProtKB=Q39023	Mitogen-activated protein kinase 3	ISS			PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04393	Ras Pathway	P04570	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=3025|UniProtKB=P21917	D(4) dopamine receptor	IDA	12181435	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00008	Axon guidance mediated by Slit/Robo	P00342	Slit	BOVIN|Ensembl=ENSBTAG00000043991|UniProtKB=E1BP10	Uncharacterized protein	ISS	10102268	PubMed	PTHR24373:SF39	SLIT HOMOLOG 1 PROTEIN
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00011	Blood coagulation	P00418	Fibrin monomer	BOVIN|Gene=FGG|UniProtKB=P12799	Fibrinogen gamma-B chain	ISS	120140	gi	PTHR19143:SF338	FIBRINOGEN GAMMA CHAIN
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	IGI	11591316	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00018	EGF receptor signaling pathway	P00539	14-3-3	CAEEL|WormBase=WBGene00003920|UniProtKB=P41932	14-3-3-like protein 1	IGI	21643941	PubMed	PTHR18860:SF21	14-3-3-LIKE PROTEIN 1
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=4599|UniProtKB=Q14831	Metabotropic glutamate receptor 7	IDA	12488551	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	89186920	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00010	B cell activation	P00385	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	20010089	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	TRYB2|Gene=Tb11.v4.0006|UniProtKB=Q382Q1	Ribonucleoside-diphosphate reductase small chain	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00047	PDGF signaling pathway	P01151	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	RCA	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P02727	Androgen/estrogene/progesterone biosynthesis	P02826	Estradiol 17beta-dehydrogenase	RAT|RGD=2836|UniProtKB=P51657	Estradiol 17-beta-dehydrogenase 1	RCA			PTHR43391:SF15	ESTRADIOL 17-BETA-DEHYDROGENASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01078	VAChT	ANOGA|EnsemblGenome=AGAP002369|UniProtKB=Q7PR83	AGAP002369-PA	ISS	7938002	PubMed	PTHR23506:SF13	VESICULAR ACETYLCHOLINE TRANSPORTER
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	BOVIN|Ensembl=ENSBTAG00000012927|UniProtKB=A6QLL8	Fructose-bisphosphate aldolase	ISS	3391172	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P06959	CCKR signaling map	P07106	IRS1	HUMAN|HGNC=6125|UniProtKB=P35568	Insulin receptor substrate 1	RCA	10400698	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P04393	Ras Pathway	P04558	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	IDA	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00021	FGF signaling pathway	P00642	MEK1-2	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IGI	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00877	MLCK	HUMAN|HGNC=16243|UniProtKB=Q9H1R3	Myosin light chain kinase 2, skeletal/cardiac muscle	IDA	11157482	PubMed	PTHR45210:SF1	MYOSIN LIGHT CHAIN KINASE 2, SKELETAL/CARDIAC MUSCLE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	MACMU|Ensembl=ENSMMUG00000020534|UniProtKB=F6TWF0	Serine/threonine-protein kinase PAK 6	ISS			PTHR24361:SF182	SERINE/THREONINE-PROTEIN KINASE PAK 6
P04375	5HT3 type receptor mediated signaling pathway	P04425	K+ channel	RAT|RGD=621451|UniProtKB=Q9ES08	Potassium channel subfamily K member 9	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01411	Ras	CAEBR|Gene=CBG06092|UniProtKB=A8X0X5	Protein CBR-LET-60	ISS	12024031	PubMed	PTHR24070:SF385	GTPASE HRAS
P00013	Cell cycle	P00480	Proteasome	HUMAN|HGNC=9560|UniProtKB=O43242	26S proteasome non-ATPase regulatory subunit 3	NAS	4506229	gi	PTHR10758:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	PANTR|Ensembl=ENSPTRG00000009125|UniProtKB=H2R9P0	Uncharacterized protein	ISS	10941822	PubMed	PTHR10489:SF635	C-C CHEMOKINE RECEPTOR TYPE 7
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	NEUCR|EnsemblGenome=EFNCRG00000008063|UniProtKB=P22572	Carbamoyl-phosphate synthase arginine-specific small chain, mitochondrial	ISS			PTHR11405:SF4	CARBAMOYL-PHOSPHATE SYNTHASE ARGININE-SPECIFIC SMALL CHAIN
P05912	Dopamine receptor mediated signaling pathway	P05961	DOPA decarb.	HUMAN|HGNC=2719|UniProtKB=P20711	Aromatic-L-amino-acid decarboxylase	ISS	90339966	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02775	Salvage pyrimidine ribonucleotides	P03150	Uridine kinase	BOVIN|Ensembl=ENSBTAG00000010810|UniProtKB=Q0P5A4	Uridine-cytidine kinase 1	ISS			PTHR10285:SF66	URIDINE-CYTIDINE KINASE 1
P00034	Integrin signalling pathway	P00912	Arp2/3	BOVIN|Ensembl=ENSBTAG00000004242|UniProtKB=Q1JP79	Actin-related protein 2/3 complex subunit 1A	ISS	12963527	gi	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P06664	Gonadotropin-releasing hormone receptor pathway	P06834	MAP3Ks	MOUSE|MGI=MGI=1346875|UniProtKB=O08648	Mitogen-activated protein kinase kinase kinase 4	RCA	97236778	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DANRE|ZFIN=ZDB-GENE-040426-1489|UniProtKB=Q6PHV0	Syntaxin 3A	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P04397	p53 pathway by glucose deprivation	G04706	TSC2	CANLF|Ensembl=ENSCAFG00000019438|UniProtKB=F1Q054	Uncharacterized protein	ISS	15249583	PubMed	PTHR10063:SF0	TUBERIN
P02746	Heme biosynthesis	P02973	Uroporphyrinogen methyltransferase	ARATH|TAIR=AT5G40850|UniProtKB=Q42606	AT5g40850/MHK7_8	ISS			PTHR21091:SF158	SUBFAMILY NOT NAMED
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	MOUSE|MGI=MGI=2677491|UniProtKB=Q920P5	Adenylate kinase isoenzyme 5	ISS			PTHR23359:SF79	ADENYLATE KINASE ISOENZYME 5
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	CHICK|Ensembl=ENSGALG00000011558|UniProtKB=F1NWV6	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06959	CCKR signaling map	P07228	MAPK1/3	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	RCA	15153424	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MOUSE|MGI=MGI=1931027|UniProtKB=Q9ER00	Syntaxin-12	ISS	10321247	PubMed	PTHR19957:SF88	SYNTAXIN-12
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	BOVIN|Ensembl=ENSBTAG00000010906|UniProtKB=E1BN61	Ribosomal protein S6 kinase	ISS	9687510	PubMed	PTHR24351:SF115	RIBOSOMAL PROTEIN S6 KINASE ALPHA-5
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	MYCTU|EnsemblGenome=Rv3411c|UniProtKB=P9WKI7	Inosine-5'-monophosphate dehydrogenase	ISS			PTHR11911:SF6	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE
P00034	Integrin signalling pathway	P00941	Integrin alpha	DROME|FlyBase=FBgn0001250|UniProtKB=P12080	Integrin alpha-PS2	IPI	3487386	PubMed	PTHR23220:SF117	INTEGRIN ALPHA-PS2
P06214	GBB signaling pathway	P06307	SAX	DROME|Gene=Dmel_CG1891|UniProtKB=A0A0B4K7J3	Receptor protein serine/threonine kinase	IDA	8134837	PubMed	PTHR23255:SF72	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00036	Interleukin signaling pathway	P00970	Interleukin	MOUSE|MGI=MGI=96537|UniProtKB=P18893	Interleukin-10	IC			PTHR44875:SF1	INTERLEUKIN-10
P00057	Wnt signaling pathway	P01465	Ggamma	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MOUSE|MGI=MGI=101848|UniProtKB=P62881	Guanine nucleotide-binding protein subunit beta-5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00048	PI3 kinase pathway	P01177	P110ACT	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	IC	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	8649368	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00056	VEGF signaling pathway	P01414	PLC-gamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DROME|FlyBase=FBgn0000044|UniProtKB=P53501	Actin-57B	ISS	14684598	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P04395	Vasopressin synthesis	P04593	Glycopeptide	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00057	Wnt signaling pathway	P01456	beta-arrestin	ANOGA|Gene=AgaP_AGAP011360|UniProtKB=Q7Q2V9	AGAP011360-PA (Fragment)	IDA	9388255	PubMed	PTHR11792:SF17	KURTZ ARRESTIN
P00030	Hypoxia response via HIF activation	P00818	HIF-1alpha	MACMU|Ensembl=ENSMMUG00000021002|UniProtKB=F7HKJ2	Uncharacterized protein	ISS	9606183	PubMed	PTHR23043:SF7	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00391	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00476	Yes	XENTR|Xenbase=XB-GENE-495082|UniProtKB=Q640S9	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF90	TYROSINE-PROTEIN KINASE YES
P00021	FGF signaling pathway	P00627	ERK1-2	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02749	Leucine biosynthesis	P03001	3-Isopropylmalate dehydrogenase	NEUCR|EnsemblGenome=EFNCRG00000005957|UniProtKB=P34738	3-isopropylmalate dehydrogenase	ISS			PTHR42979:SF1	3-ISOPROPYLMALATE DEHYDROGENASE
P00012	Cadherin signaling pathway	P00464	Fyn	PANTR|Ensembl=ENSPTRG00000018511|UniProtKB=H2QTK7	Tyrosine-protein kinase	ISS	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00015	Circadian clock system	P00502	Casein kinase I	RAT|RGD=71031|UniProtKB=Q06486	Casein kinase I isoform delta	ISS	11437445	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P05730	Endogenous cannabinoid signaling	P05746	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00012	Cadherin signaling pathway	P00475	Frizzled	CAEEL|WormBase=WBGene00003006|UniProtKB=G5EDV1	Transmembrane receptor LIN-17	ISS	8717036	PubMed	PTHR11309:SF130	TRANSMEMBRANE RECEPTOR LIN-17
P00018	EGF receptor signaling pathway	P00547	PP2A	HUMAN|HGNC=9299|UniProtKB=P67775	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	NAS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	RAT|RGD=61862|UniProtKB=P19491	Glutamate receptor 2	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00003	Alzheimer disease-amyloid secretase pathway	P00079	alpha7 nicotinic acetylcholine receptor	RAT|RGD=2348|UniProtKB=Q05941	Neuronal acetylcholine receptor subunit alpha-7	IDA	11404397	PubMed	PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P04397	p53 pathway by glucose deprivation	P04639	AMPK	XENTR|Xenbase=XB-GENE-5994580|UniProtKB=F6R539	Uncharacterized protein	ISS			PTHR24343:SF303	5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	BOVIN|Gene=SSTR2|UniProtKB=P34993	Somatostatin receptor type 2	ISS			PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00562	p38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	IGI	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00020	FAS signaling pathway	P00615	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00046	Oxidative stress response	P01129	JNK1/2	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	TAS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00718	Phosphorylase a	CANLF|Ensembl=ENSCAFG00000014281|UniProtKB=F1P832	Alpha-1,4 glucan phosphorylase	ISS	4318782	PubMed	PTHR11468:SF13	GLYCOGEN PHOSPHORYLASE, MUSCLE FORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	IDA	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	TAS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00094	BACE-1 pro-domain	PANTR|Ensembl=ENSPTRG00000013924|UniProtKB=H2R1L7	Beta-site APP-cleaving enzyme 2	ISS			PTHR13683:SF262	BETA-SECRETASE 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00006	Apoptosis signaling pathway	P00269	MAPK	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P04398	p53 pathway feedback loops 2	P04661	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	ISS	96009592	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00018	EGF receptor signaling pathway	P00562	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01428	Frizzled	HUMAN|HGNC=4041|UniProtKB=Q9NPG1	Frizzled-3	IDA	8717036	PubMed	PTHR11309:SF22	FRIZZLED-3
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00925	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	IDA	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00018	EGF receptor signaling pathway	P00562	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TAKRU|Ensembl=ENSTRUG00000005447|UniProtKB=P68142	Actin, cytoplasmic 1	IC	3487386	PubMed	PTHR11937:SF354	SUBFAMILY NOT NAMED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00644	p38	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	IDA	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	DEIRA|EnsemblGenome=DR_2611|UniProtKB=P56926	Glutamine--tRNA ligase	ISS			PTHR43097:SF5	GLUTAMATE--TRNA LIGASE, CYTOPLASMIC
P00005	Angiogenesis	P00236	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01211	ERK	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	IDA	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	8836152	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00047	PDGF signaling pathway	P01159	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Ensembl=ENSGALG00000014620|UniProtKB=F1N8P3	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00555	MKK4,7	HUMAN|HGNC=6844|UniProtKB=P45985	Dual specificity mitogen-activated protein kinase kinase 4	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04395	Vasopressin synthesis	P04594	Neurophysin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	CAEBR|Gene=CBG02850|UniProtKB=A8WTD8	Protein CBG02850	ISS			PTHR10937:SF0	GH12731P-RELATED
P02746	Heme biosynthesis	P02983	Hydroxymethylbilane synthase	CHLTR|EnsemblGenome=CT_299|UniProtKB=O84301	Probable porphobilinogen deaminase	ISS			PTHR11557:SF0	PORPHOBILINOGEN DEAMINASE
P00060	Ubiquitin proteasome pathway	P01491	E2	PANTR|Ensembl=ENSPTRG00000020231|UniProtKB=H2QW50	Uncharacterized protein	ISS			PTHR43915:SF3	UBIQUITIN-CONJUGATING ENZYME E2 VARIANT 2
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	HUMAN|HGNC=9508|UniProtKB=P49768	Presenilin-1	TAS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00018	EGF receptor signaling pathway	P00560	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	DANRE|ZFIN=ZDB-GENE-000330-9|UniProtKB=Q90ZE4	Presenilin-2	TAS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00053	T cell activation	P01318	PKC-theta	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IGI	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00539	14-3-3	CHICK|Ensembl=ENSGALG00000010725|UniProtKB=Q5ZKC9	14-3-3 protein zeta	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P04393	Ras Pathway	P04569	Cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CANLF|Ensembl=ENSCAFG00000005662|UniProtKB=E2R907	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	DROME|FlyBase=FBgn0003889|UniProtKB=P61857	Tubulin beta-2 chain	ISS	9454836	PubMed	PTHR11588:SF155	TUBULIN BETA-2 CHAIN
P00015	Circadian clock system	P00502	Casein kinase I	HUMAN|HGNC=2453|UniProtKB=P49674	Casein kinase I isoform epsilon	ISS	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	BOVIN|Gene=SLC18A2|UniProtKB=Q27963	Synaptic vesicular amine transporter	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8693|UniProtKB=Q9UN66	Protocadherin beta-8	IDA	8120095	PubMed	PTHR24028:SF150	PROTOCADHERIN BETA-8
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02746	Heme biosynthesis	P02970	Coproporphyrinogen oxidase (oxygen independent)	SYNY3|EnsemblGenome=BAA17272|UniProtKB=P73245	Oxygen-independent coproporphyrinogen-III oxidase-like protein sll1917	ISS			PTHR13932:SF5	OXYGEN-INDEPENDENT COPROPORPHYRINOGEN-III OXIDASE-LIKE PROTEIN YGGW
P00021	FGF signaling pathway	P00641	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00029	Huntington disease	P00796	Kainate receptor	BOVIN|Ensembl=ENSBTAG00000011723|UniProtKB=E1BKL6	Uncharacterized protein	ISS	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00047	PDGF signaling pathway	P01160	IP3 receptor	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	CAEEL|WormBase=WBGene00001172|UniProtKB=G5ECN9	Prohormone convertase 2	IDA			PTHR42884:SF13	NEUROENDOCRINE CONVERTASE 2
P00018	EGF receptor signaling pathway	P00542	EGFR	PANTR|Ensembl=ENSPTRG00000012883|UniProtKB=H2QJC5	Receptor protein-tyrosine kinase	ISS	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00049	Parkinson disease	P01211	ERK	MOUSE|MGI=MGI=1346347|UniProtKB=Q9WVS8	Mitogen-activated protein kinase 7	IDA	15085193	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00006	Apoptosis signaling pathway	P00274	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00020	FAS signaling pathway	P00601	c-Jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00029	Huntington disease	P00807	Actin	SCHMA|EnsemblGenome=Smp_046600|UniProtKB=G4VLW2	Putative actin-1	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00576	Pre-pro ET1-4	BOVIN|Ensembl=ENSBTAG00000021434|UniProtKB=Q867A9	Endothelin-2	ISS			PTHR13874:SF9	ENDOTHELIN-2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04555	PDK	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	15210700	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	HUMAN|HGNC=19663|UniProtKB=Q9UBI6	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IDA	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00023	General transcription regulation	P00668	TFIIB	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g190658|UniProtKB=A7SJZ7	Predicted protein	ISS			PTHR12458:SF8	CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	CAEEL|WormBase=WBGene00019096|UniProtKB=O16284	Cysteine synthase	ISS			PTHR10314:SF71	CYSTEINE SYNTHASE-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04453	ACTH	DANRE|ZFIN=ZDB-GENE-030513-2|UniProtKB=Q7ZT18	Pro-opiomelanocortin protein	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00036	Interleukin signaling pathway	P00965	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01472	Histone deacetylase	CHICK|Ensembl=ENSGALG00000003297|UniProtKB=P56517	Histone deacetylase 1	IDA	10485845	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P00006	Apoptosis signaling pathway	P00277	Bi1	ARATH|TAIR=AT5G47130|UniProtKB=Q9LTB6	Bax inhibitor-1 family protein	ISS			PTHR23291:SF34	BAX INHIBITOR 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00021	FGF signaling pathway	P00642	MEK1-2	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IGI	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00774	Dynein complex	CHLRE|EnsemblGenome=CHLREDRAFT_194837|UniProtKB=A8JH45	Outer dynein arm light chain 8	IPI	9454836	PubMed	PTHR11886:SF35	DYNEIN LIGHT CHAIN 2, CYTOPLASMIC
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	RCA	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00036	Interleukin signaling pathway	P00974	Receptor subunit beta	HUMAN|HGNC=6009|UniProtKB=P14784	Interleukin-2 receptor subunit beta	IDA	11238664	PubMed	PTHR23037:SF30	INTERLEUKIN-2 RECEPTOR SUBUNIT BETA
P04393	Ras Pathway	P04558	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	IDA	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95811|UniProtKB=Q9Z2W8	Glutamate receptor 4	ISS	12871085	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00018	EGF receptor signaling pathway	P00564	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	10802295	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	ISS	12488551	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00021	FGF signaling pathway	P00645	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	10540223	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=1310389|UniProtKB=D3ZTF6	Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Predicted), isoform CRA_a	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	HUMAN|HGNC=9508|UniProtKB=P49768	Presenilin-1	IDA	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	PANTR|Ensembl=ENSPTRG00000017549|UniProtKB=H2QS18	Dopamine receptor D1	ISS	15328036	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P05913	Enkephalin release	G06045	preproenkephalin	HUMAN|HGNC=8831|UniProtKB=P01210	Proenkephalin-A	IC	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00018	EGF receptor signaling pathway	P00545	JNK1-3	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	TAS	97102676	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P02738	De novo purine biosynthesis	P02891	GDP kinase	MOUSE|MGI=MGI=1922783|UniProtKB=Q99MH5	Nucleoside diphosphate kinase homolog 5	ISS			PTHR11349:SF64	NUCLEOSIDE DIPHOSPHATE KINASE HOMOLOG 5
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00059	p53 pathway	P04630	PP2A	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00005	Angiogenesis	P00203	Erk	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00048	PI3 kinase pathway	P01179	PKB	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00564	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00036	Interleukin signaling pathway	P00996	STAT	CANLF|Ensembl=ENSCAFG00000015509|UniProtKB=F1PNW8	Signal transducer and activator of transcription	ISS	10835485	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P04393	Ras Pathway	P04557	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IDA	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00018	EGF receptor signaling pathway	P00560	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	CANLF|Ensembl=ENSCAFG00000000433|UniProtKB=F1PGJ3	Uncharacterized protein	ISS			PTHR10937:SF10	GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE  ISOMERIZING  2
P00036	Interleukin signaling pathway	P00994	FKHRL1	RAT|RGD=1309196|UniProtKB=D3ZBQ1	Forkhead box O3a (Predicted)	ISS	10102273	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	EMENI|EnsemblGenome=CADANIAG00002113|UniProtKB=O93937	Protein pyrABCN	ISS			PTHR11405:SF5	CAD PROTEIN
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00976	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IGI	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00941	Integrin alpha	BOVIN|Ensembl=ENSBTAG00000007602|UniProtKB=E1BNM2	Uncharacterized protein	ISS	10778855	PubMed	PTHR23220:SF5	INTEGRIN ALPHA-8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	CAEEL|WormBase=WBGene00004344|UniProtKB=P34295	Regulator of G-protein signaling rgs-1	IDA	8756726	PubMed	PTHR10845:SF192	AXIN-RELATED
P00047	PDGF signaling pathway	P01168	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PLAF7|EnsemblGenome=PF14_0124|UniProtKB=Q8ILW9	Actin-2	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00034	Integrin signalling pathway	P00924	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P05913	Enkephalin release	P05974	G-Protein (i)	CAEEL|WormBase=WBGene00001679|UniProtKB=P17343	Guanine nucleotide-binding protein subunit beta-1	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04559	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12912997	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00019	Endothelin signaling pathway	P00572	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	11292874	PubMed	PTHR10048:SF14	PI-3 KINASE
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	XENTR|Ensembl=ENSXETG00000021375|UniProtKB=F6T423	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	HUMAN|HGNC=9189|UniProtKB=P19387	DNA-directed RNA polymerase II subunit RPB3	ISS	2187864	PubMed	PTHR11800:SF2	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	METAC|EnsemblGenome=MA_0278|UniProtKB=Q8TTZ7	TATA-box-binding protein 3	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MACMU|Ensembl=ENSMMUG00000001661|UniProtKB=F7GR69	Uncharacterized protein	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00005	Angiogenesis	P00238	Ras	MONDO|Gene=KRAS|UniProtKB=Q07983	GTPase KRas	ISS	99084794	PubMed	PTHR24070:SF186	GTPASE KRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00048	PI3 kinase pathway	P01188	Gbetagamma	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00004	Alzheimer disease-presenilin pathway	P00139	E-cadherin transmembrane fragment	RAT|RGD=621089|UniProtKB=F1LMI3	Cadherin 3, type 1, P-cadherin (Placental)	ISS	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	CHICK|Ensembl=ENSGALG00000001334|UniProtKB=F1NLV4	Uncharacterized protein	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=4598|UniProtKB=O15303	Metabotropic glutamate receptor 6	IDA	12351712	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=1855700|UniProtKB=O55134	Protocadherin-12	IDA	8120095	PubMed	PTHR24028:SF42	PROTOCADHERIN-12
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IDA	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MONDO|Ensembl=ENSMODG00000018415|UniProtKB=F6XUZ7	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00012	Cadherin signaling pathway	P00470	F-actin	DROME|FlyBase=FBgn0000045|UniProtKB=P02574	Actin, larval muscle	IC	10974003	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00053	T cell activation	P01311	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00007	Axon guidance mediated by semaphorins	P00331	PAK	CHICK|Ensembl=ENSGALG00000000681|UniProtKB=E1C3P6	Uncharacterized protein	ISS	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00705	Gsalpha	MACMU|Ensembl=ENSMMUG00000010266|UniProtKB=F6PV18	Uncharacterized protein	ISS	6309844	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000004896|UniProtKB=F7C2C6	Uncharacterized protein (Fragment)	ISS	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02777	Succinate to proprionate conversion	P03163	Methylmalonyl-CoA decarboxylase	PANTR|Ensembl=ENSPTRG00000015431|UniProtKB=H2QNF5	Propionyl CoA carboxylase, beta polypeptide	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00021	FGF signaling pathway	P00636	FGFR1-4	ORNAN|Ensembl=ENSOANG00000003252|UniProtKB=F6SM70	Fibroblast growth factor receptor	ISS	9763444	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P00034	Integrin signalling pathway	P00951	Jnk	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	IDA	97102676	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00013	Cell cycle	P00480	Proteasome	CHICK|Ensembl=ENSGALG00000003700|UniProtKB=F1NPQ0	Uncharacterized protein	ISS	12477932	PubMed	PTHR10855:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00572	MEK	CAEBR|Gene=CBG04190|UniProtKB=A8WWD7	Protein CBR-MEK-2	ISS	176872	OMIM	PTHR24361:SF629	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	TAS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	ISS	8838325	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	RAT|RGD=69319|UniProtKB=P54313	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IDA			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000009766|UniProtKB=F6TFL4	Uncharacterized protein	ISS	8444355	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P04393	Ras Pathway	P04558	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00632	Akt	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	IGI	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P06664	Gonadotropin-releasing hormone receptor pathway	P06850	PKCs(3)	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	HUMAN|HGNC=704|UniProtKB=O15143	Actin-related protein 2/3 complex subunit 1B	ISS	12473693	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00029	Huntington disease	P00777	CBP	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00012	Cadherin signaling pathway	P00470	F-actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	IC	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000009085|UniProtKB=H2RDQ2	Uncharacterized protein	ISS	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00049	Parkinson disease	P01219	SAPK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02738	De novo purine biosynthesis	P02902	ADP reductase	ECOLI|EcoGene=EG20257|UniProtKB=P39452	Ribonucleoside-diphosphate reductase 2 subunit alpha	ISS			PTHR11573:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT ALPHA
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MACMU|Ensembl=ENSMMUG00000009759|UniProtKB=F6ZIH3	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF504	MYOSIN-13
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00036	Interleukin signaling pathway	P00971	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	7689150	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00049	Parkinson disease	P01211	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00025	Hedgehog signaling pathway	P00682	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	HUMAN|HGNC=6854|UniProtKB=Q9Y2U5	Mitogen-activated protein kinase kinase kinase 2	NAS	8649450	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00590	IP3 R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=98957|UniProtKB=P22724	Protein Wnt-4	IDA	11266476	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P06664	Gonadotropin-releasing hormone receptor pathway	P06777	NFAT	MOUSE|MGI=MGI=102469|UniProtKB=O88942	Nuclear factor of activated T-cells, cytoplasmic 1	RCA			PTHR12533:SF5	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00005	Angiogenesis	P00252	Grb2	MOUSE|MGI=MGI=1918770|UniProtKB=Q9CX99	GRB2-related adapter protein	ISS			PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IDA	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00029	Huntington disease	P00807	Actin	ORYSJ|Gene=Os01g0866100|UniProtKB=P0C540	Actin-7	IDA	11889126	PubMed	PTHR11937:SF205	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	RAT|RGD=1359694|UniProtKB=P62836	Ras-related protein Rap-1A	ISS	10476970	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P02775	Salvage pyrimidine ribonucleotides	P03150	Uridine kinase	CHICK|Ensembl=ENSGALG00000006040|UniProtKB=F1NB19	Uridine-cytidine kinase	ISS			PTHR10285:SF68	URIDINE-CYTIDINE KINASE-LIKE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	RAT|RGD=2342|UniProtKB=P08482	Muscarinic acetylcholine receptor M1	IDA	12181435	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P04393	Ras Pathway	P04572	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	IDA	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00029	Huntington disease	P00811	Arp2/3 complex	DICDI|dictyBase=DDB_G0277825|UniProtKB=O96622	Actin-related protein 2/3 complex subunit 1	TAS	12963527	gi	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P00034	Integrin signalling pathway	P00912	Arp2/3	PANTR|Ensembl=ENSPTRG00000021362|UniProtKB=H2QXW1	Actin-related protein 2/3 complex subunit 5	ISS	12932731	PubMed	PTHR12644:SF2	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5-LIKE PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF31	SUBFAMILY NOT NAMED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	PANTR|Ensembl=ENSPTRG00000000543|UniProtKB=H2PYN8	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	HUMAN|HGNC=130|UniProtKB=P62736	Actin, aortic smooth muscle	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00046	Oxidative stress response	P01135	p38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00005	Angiogenesis	P00239	Eph	CANLF|Ensembl=ENSCAFG00000016734|UniProtKB=E2QSB5	Uncharacterized protein	ISS			PTHR11304:SF17	EPHRIN-B1
P00059	p53 pathway	G01575	GADD45	MACMU|Ensembl=ENSMMUG00000014808|UniProtKB=F6W540	Growth arrest and DNA damage-inducible protein GADD45 alpha isoform 1	ISS	9827804	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CAEEL|WormBase=WBGene00004055|UniProtKB=Q17446	Mitogen-activated protein kinase pmk-1	TAS			PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00053	T cell activation	P01320	PLC-gamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00005	Angiogenesis	P00190	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	HUMAN|HGNC=5289|UniProtKB=P28221	5-hydroxytryptamine receptor 1D	IEA	12181435	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	94280860	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00047	PDGF signaling pathway	P01152	RasGAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	ISS	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MOUSE|MGI=MGI=103302|UniProtKB=P23359	Bone morphogenetic protein 7	TAS	9759503	PubMed	PTHR11848:SF135	BONE MORPHOGENETIC PROTEIN 7
P00048	PI3 kinase pathway	P01177	P110ACT	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01294	NFAT	PANTR|Ensembl=ENSPTRG00000008260|UniProtKB=H2QBD7	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	ISS	12015605	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00048	PI3 kinase pathway	P01187	IR	CANLF|Ensembl=ENSCAFG00000018170|UniProtKB=E2RPM8	Tyrosine-protein kinase receptor	ISS	249616	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00045	Notch signaling pathway	P01104	Serrate	MOUSE|MGI=MGI=1098270|UniProtKB=Q9QYE5	Protein jagged-2	ISS	12826675	PubMed	PTHR44097:SF1	PROTEIN JAGGED-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P06664	Gonadotropin-releasing hormone receptor pathway	P06795	STAT3	MOUSE|MGI=MGI=103038|UniProtKB=P42227	Signal transducer and activator of transcription 3	RCA	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P05913	Enkephalin release	P05974	G-Protein (i)	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	PANTR|Ensembl=ENSPTRG00000012911|UniProtKB=H2QJE2	Uncharacterized protein	ISS	12473693	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00005	Angiogenesis	P00220	c-Jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	11840290	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P05913	Enkephalin release	P05974	G-Protein (i)	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	SCHMA|EnsemblGenome=Smp_059340|UniProtKB=C4QDC7	Guanine nucleotide-binding protein G(S) subunit alpha (Adenylate cyclase-stimulating G alpha protein),putative	IC			PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	HUMAN|HGNC=174|UniProtKB=Q13705	Activin receptor type-2B	TAS	9395284	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	PANTR|Ensembl=ENSPTRG00000007084|UniProtKB=H2Q9G5	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=621019|UniProtKB=Q08850	Syntaxin-4	ISS			PTHR19957:SF97	SYNTAXIN-4
P00048	PI3 kinase pathway	P01194	S6K	MOUSE|MGI=MGI=1270849|UniProtKB=Q8BSK8	Ribosomal protein S6 kinase beta-1	IDA	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00021	FGF signaling pathway	P00624	14-3-3	XENTR|Xenbase=XB-GENE-996375|UniProtKB=F7DY42	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00052	TGF-beta signaling pathway	P01285	TAK	RAT|RGD=1309438|UniProtKB=P0C8E4	Mitogen-activated protein kinase kinase kinase 7	RCA			PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P02738	De novo purine biosynthesis	P02901	Adenosuccinate lyase	PSEAE|EnsemblGenome=PA2629|UniProtKB=Q9I0K9	Adenylosuccinate lyase	ISS			PTHR43411:SF3	ADENYLOSUCCINATE LYASE
P00034	Integrin signalling pathway	P00907	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00059	p53 pathway	P04630	PP2A	MOUSE|MGI=MGI=1321161|UniProtKB=P62715	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00029	Huntington disease	P00810	GAPDH	AQUAE|EnsemblGenome=aq_1065|UniProtKB=O67161	Glyceraldehyde-3-phosphate dehydrogenase	IPI			PTHR43148:SF2	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE C-RELATED
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05731	GABA-B receptor II signaling	P05754	Ggamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00037	Ionotropic glutamate receptor pathway	P01026	KA	PANTR|Ensembl=ENSPTRG00000018449|UniProtKB=H2QTG5	Uncharacterized protein	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00558	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	RAT|RGD=1598310|UniProtKB=Q4KLN6	Ribonucleoside-diphosphate reductase subunit M2	ISS			PTHR23409:SF20	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	XENTR|Xenbase=XB-GENE-5801166|UniProtKB=F6ZE26	Uncharacterized protein	ISS	1904317	PubMed	PTHR24070:SF382	RAS-RELATED PROTEIN RAP-1B
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	ISS			PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00566	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02765	Phenylalanine biosynthesis	P03099	Prephenate dehydratase	LEPIN|EnsemblGenome=LA_1256|UniProtKB=Q8F6P7	Bifunctional prephenate dehydratase/chorismate mutase	ISS			PTHR21022:SF0	PREPHENATE DEHYDRATASE-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01159	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00021	FGF signaling pathway	P00636	FGFR1-4	CANLF|Ensembl=ENSCAFG00000005970|UniProtKB=E2R186	Fibroblast growth factor receptor	ISS	9763444	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P00029	Huntington disease	P00778	NMDA receptor	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	IDA	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00005	Angiogenesis	P00219	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00049	Parkinson disease	P01208	Hsp70	ARATH|TAIR=AT3G09440|UniProtKB=O65719	Heat shock 70 kDa protein 3	IDA	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00029	Huntington disease	P00796	Kainate receptor	MACMU|Ensembl=ENSMMUG00000017431|UniProtKB=F7HPP3	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P02785	Valine biosynthesis	P03215	Branched chain amino acid aminotransferase	NEUCR|Gene=NCU04292|UniProtKB=Q1K779	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF69	SUBFAMILY NOT NAMED
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00018	EGF receptor signaling pathway	P00559	MEK1-2	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IGI	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	PANTR|Ensembl=ENSPTRG00000001368|UniProtKB=H2Q045	Uncharacterized protein	RCA			PTHR22952:SF105	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 4
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01316	MHC-antigen	CHICK|Ensembl=ENSGALG00000004594|UniProtKB=Q6J613	Invariant chain isoform p41	IPI	73139	PubMed	PTHR14093:SF17	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN GAMMA CHAIN
P00059	p53 pathway	P04612	HDAC1	DANRE|ZFIN=ZDB-GENE-020419-32|UniProtKB=F1R653	Histone deacetylase	ISS	12665570	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P00057	Wnt signaling pathway	P01456	beta-arrestin	MOUSE|MGI=MGI=99473|UniProtKB=Q8BWG8	Beta-arrestin-1	ISS	4757780	gi	PTHR11792:SF22	BETA-ARRESTIN-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ASHGO|EnsemblGenome=AGOS_ABR222W|UniProtKB=Q75D00	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	HUMAN|HGNC=10485|UniProtKB=Q15413	Ryanodine receptor 3	ISS	15226293	PubMed	PTHR13715:SF16	RYANODINE RECEPTOR 3
P00048	PI3 kinase pathway	P01188	Gbetagamma	DICDI|dictyBase=DDB_G0277143|UniProtKB=P36408	Guanine nucleotide-binding protein subunit beta	IC	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00887	IRS 1-4	BOVIN|Ensembl=ENSBTAG00000021308|UniProtKB=F1MYE0	Uncharacterized protein	ISS	1311924	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ANOGA|EnsemblGenome=AGAP000651|UniProtKB=P84185	Actin-5C	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000010521|UniProtKB=F7DQK7	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	MACMU|Ensembl=ENSMMUG00000018272|UniProtKB=F7HEB8	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00054	Toll receptor signaling pathway	P01377	MyD88	RAT|RGD=735043|UniProtKB=Q6Y1S1	Myeloid differentiation primary response protein MyD88	ISS			PTHR15079:SF3	MYELOID DIFFERENTIATION PRIMARY RESPONSE PROTEIN MYD88
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00046	Oxidative stress response	P01123	Bcl-2	RAT|RGD=2199|UniProtKB=P49950	Apoptosis regulator Bcl-2	TAS	11323415	PubMed	PTHR11256:SF11	APOPTOSIS REGULATOR BCL-2
P00053	T cell activation	P01332	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01405	VRAP	MOUSE|MGI=MGI=1351596|UniProtKB=Q9QXK9	SH2 domain-containing protein 2A	IDA	Q9NP31	SPACC	PTHR14388:SF9	SH2 DOMAIN-CONTAINING PROTEIN 2A
P05918	p38 MAPK pathway	P06020	p38delta	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00021	FGF signaling pathway	P00641	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04393	Ras Pathway	P04567	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00643	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00047	PDGF signaling pathway	P01163	c-Jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04398	p53 pathway feedback loops 2	P04665	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01124	Myc	CANLF|Gene=MYC|UniProtKB=Q28350	Myc proto-oncogene protein	TAS	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	TAKRU|Ensembl=ENSTRUG00000013411|UniProtKB=H2UB84	Uncharacterized protein	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00640	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	1171954	gi	PTHR10048:SF14	PI-3 KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	ISS	129387	gi	PTHR10048:SF14	PI-3 KINASE
P00053	T cell activation	P01294	NFAT	HUMAN|HGNC=7775|UniProtKB=O95644	Nuclear factor of activated T-cells, cytoplasmic 1	IGI	9133421	PubMed	PTHR12533:SF5	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 1
P00029	Huntington disease	P00807	Actin	HUMAN|HGNC=145|UniProtKB=P63267	Actin, gamma-enteric smooth muscle	IDA	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00047	PDGF signaling pathway	P01167	Ets	ORNAN|Ensembl=ENSOANG00000012104|UniProtKB=F7FH70	Uncharacterized protein	ISS	3060801	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00054	Toll receptor signaling pathway	P01346	TLR	HUMAN|HGNC=11848|UniProtKB=O60603	Toll-like receptor 2	ISS			PTHR24365:SF17	TOLL-LIKE RECEPTOR 2
P00036	Interleukin signaling pathway	P00977	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00059	p53 pathway	P04609	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00940	Src	STRPU|EnsemblGenome=SPU_013522|UniProtKB=Q8WQM5	Tyrosine-protein kinase	IPI	11078745	PubMed	PTHR24418:SF292	TYROSINE-PROTEIN KINASE SRC42A
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176910	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=4600|UniProtKB=O00222	Metabotropic glutamate receptor 8	IDA	12351712	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00059	p53 pathway	P01486	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04553	PAK	BOVIN|Ensembl=ENSBTAG00000010191|UniProtKB=Q08E52	Serine/threonine-protein kinase PAK 1	ISS	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00059	p53 pathway	G04694	p110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00373	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00034	Integrin signalling pathway	P00920	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	STRPU|EnsemblGenome=SPU_012282|UniProtKB=W4Y969	Uncharacterized protein	IDA	11889126	PubMed	PTHR11937:SF369	ACTIN-42A
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	ORNAN|Ensembl=ENSOANG00000010302|UniProtKB=F6TDQ6	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00046	Oxidative stress response	P01129	JNK1/2	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00009	Axon guidance mediated by netrin	P00366	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04374	5HT2 type receptor mediated signaling pathway	P04417	5HT transporter	PANTR|Ensembl=ENSPTRG00000008958|UniProtKB=H2QCL1	Transporter	ISS	7681602	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P05913	Enkephalin release	P05975	GPCR (s)	PANTR|Gene=OPRM1|UniProtKB=Q5IS39	Mu-type opioid receptor	ISS	11259498	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00018	EGF receptor signaling pathway	P00545	JNK1-3	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS			PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00057	Wnt signaling pathway	P01443	Phospholipase C	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01219	SAPK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00012	Cadherin signaling pathway	P00475	Frizzled	MONDO|Ensembl=ENSMODG00000008701|UniProtKB=F6PWM3	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF22	FRIZZLED-3
P02769	Purine metabolism	P03118	Guanine Deaminase	PANTR|Ensembl=ENSPTRG00000021020|UniProtKB=H2R3N5	Uncharacterized protein	ISS	11837778	gi	PTHR11271:SF6	GUANINE DEAMINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=1858236|UniProtKB=Q91ZI0	Cadherin EGF LAG seven-pass G-type receptor 3	IDA	8120095	PubMed	PTHR24026:SF38	CADHERIN EGF LAG SEVEN-PASS G-TYPE RECEPTOR 3
P00047	PDGF signaling pathway	P01154	Ras	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g247341|UniProtKB=A7STP5	Predicted protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P02788	Xanthine and guanine salvage pathway	P03247	Xanthine phosphoribosyl transferase	HUMAN|HGNC=5157|UniProtKB=P00492	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF6	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=2683547|UniProtKB=Q4KWH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1	TAS			PTHR10336:SF51	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-1
P04393	Ras Pathway	P04578	Rho	BOVIN|Ensembl=ENSBTAG00000014299|UniProtKB=Q1RMJ6	Rho-related GTP-binding protein RhoC	ISS	12090470	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00038	JAK/STAT signaling pathway	P01034	Jak	HUMAN|HGNC=6193|UniProtKB=P52333	Tyrosine-protein kinase JAK3	ISS	15179321	PubMed	PTHR24418:SF233	TYROSINE-PROTEIN KINASE JAK3
P00059	p53 pathway	G04689	Cyclin G	RAT|RGD=2295|UniProtKB=P39950	Cyclin-G1	ISS	7957050	PubMed	PTHR10177:SF59	CYCLIN-G1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000008826|UniProtKB=F6XUU0	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00034	Integrin signalling pathway	P00925	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00053	T cell activation	P01300	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05730	Endogenous cannabinoid signaling	P05746	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	BOVIN|Gene=POLR2E|UniProtKB=Q2T9T3	DNA-directed RNA polymerases I, II, and III subunit RPABC1	ISS			PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	MOUSE|MGI=MGI=1351338|UniProtKB=P97772	Metabotropic glutamate receptor 1	IC	12351712	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00053	T cell activation	P01320	PLC-gamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00005	Angiogenesis	P00238	Ras	CHICK|Ensembl=ENSGALG00000014033|UniProtKB=E1BTS2	Uncharacterized protein	ISS	9869449	PubMed	PTHR24070:SF186	GTPASE KRAS
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04395	Vasopressin synthesis	P04589	Signal Peptidase	RAT|RGD=69360|UniProtKB=P42667	Signal peptidase complex catalytic subunit SEC11A	ISS	2674115	PubMed	PTHR10806:SF8	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11A-RELATED
P00038	JAK/STAT signaling pathway	P01029	Serine kinase	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	ISS			PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	MOUSE|MGI=MGI=96606|UniProtKB=P24063	Integrin alpha-L	IDA	11457896	PubMed	PTHR23220:SF84	INTEGRIN ALPHA-L
P00059	p53 pathway	G04694	p110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00115	Nicastrin	PANTR|Ensembl=ENSPTRG00000001550|UniProtKB=H2Q0E4	Nicastrin	ISS	16096062	PubMed	PTHR21092:SF0	NICASTRIN
P00056	VEGF signaling pathway	P01413	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000005917|UniProtKB=F6QM53	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00052	TGF-beta signaling pathway	P01276	Co-Smads	DROME|FlyBase=FBgn0011655|UniProtKB=O62609	Mothers against decapentaplegic homolog	TAS	9395284	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P00054	Toll receptor signaling pathway	P01352	p38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00053	T cell activation	P01332	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	RCA			PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00048	PI3 kinase pathway	P01182	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00021	FGF signaling pathway	P00628	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00040	Metabotropic glutamate receptor group II pathway	G01540	BDNF	DANRE|ZFIN=ZDB-GENE-000412-1|UniProtKB=Q6NZ01	Bdnf protein	ISS	12117585	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P05913	Enkephalin release	P05973	GPCR (i)	CANLF|Ensembl=ENSCAFG00000011689|UniProtKB=E2QZY2	Uncharacterized protein	ISS	11259498	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00019	Endothelin signaling pathway	P00566	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00025	Hedgehog signaling pathway	P00692	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05915	Opioid proenkephalin pathway	P05990	K+ channel	HUMAN|HGNC=6283|UniProtKB=Q9NPC2	Potassium channel subfamily K member 9	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00023	General transcription regulation	P00668	TFIIB	MOUSE|MGI=MGI=2385191|UniProtKB=P62915	Transcription initiation factor IIB	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=4595|UniProtKB=Q14832	Metabotropic glutamate receptor 3	IDA	20012997	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00005	Angiogenesis	P00227	PLA2	MONDO|Ensembl=ENSMODG00000011791|UniProtKB=F7CBU9	Phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MACMU|Ensembl=ENSMMUG00000011466|UniProtKB=F7B2R8	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P02756	N-acetylglucosamine metabolism	P03040	N-acetylneuraminate lyase	MOUSE|MGI=MGI=1921341|UniProtKB=Q9DCJ9	N-acetylneuraminate lyase	ISS			PTHR12128:SF21	N-ACETYLNEURAMINATE LYASE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01375	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04375	5HT3 type receptor mediated signaling pathway	P04421	5HT transporter	MACMU|Gene=SLC6A4|UniProtKB=Q9MYX0	Sodium-dependent serotonin transporter	ISS	7681602	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DROME|FlyBase=FBgn0015765|UniProtKB=O62618	Mitogen-activated protein kinase 14A	IDA	98079070	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00020	FAS signaling pathway	P00616	Nuclear Lamin	ANOGA|EnsemblGenome=AGAP011938|UniProtKB=Q7PZJ0	AGAP011938-PA	ISS			PTHR23239:SF234	LAMIN DM0-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	YEAST|SGD=S000005738|UniProtKB=P18851	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00047	PDGF signaling pathway	P01150	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00310	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01193	IRS	MACMU|Ensembl=ENSMMUG00000019467|UniProtKB=F6SUL3	Uncharacterized protein	ISS	15110093	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00029	Huntington disease	P00807	Actin	DANRE|ZFIN=ZDB-GENE-030131-172|UniProtKB=Q6IQR3	Actin, alpha, cardiac muscle 1a	IDA	11889139	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00012	Cadherin signaling pathway	P00470	F-actin	RAT|RGD=2026|UniProtKB=P68035	Actin, alpha cardiac muscle 1	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00004	Alzheimer disease-presenilin pathway	P00126	Fe65	RAT|RGD=2122|UniProtKB=P46933	Amyloid beta A4 precursor protein-binding family B member 1	IDA	15115822	PubMed	PTHR14058:SF5	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1
P00018	EGF receptor signaling pathway	P00565	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P06959	CCKR signaling map	P07090	MAPK8-10	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	RCA		PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00006	Apoptosis signaling pathway	P00269	MAPK	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00036	Interleukin signaling pathway	P00990	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00564	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06769	Gbeta	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	RCA	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	TAS	15572354	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P05913	Enkephalin release	P05972	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04559	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00047	PDGF signaling pathway	P01171	PLCgamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	HUMAN|HGNC=711|UniProtKB=P49407	Beta-arrestin-1	ISS	9388255	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04397	p53 pathway by glucose deprivation	P04641	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00054	Toll receptor signaling pathway	P01369	MKK1	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	PANTR|Ensembl=ENSPTRG00000007348|UniProtKB=H2Q9W8	Uncharacterized protein	ISS	22213672	PubMed	PTHR18945:SF385	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-4
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	CHICK|Ensembl=ENSGALG00000002859|UniProtKB=F6UBD2	Uncharacterized protein	ISS	9252344	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00848	Grb	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	7689150	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P02775	Salvage pyrimidine ribonucleotides	P03150	Uridine kinase	ECOLI|EcoGene=EG11701|UniProtKB=P0A8F4	Uridine kinase	ISS			PTHR10285:SF6	ATP-DEPENDENT KINASE TDA10-RELATED
P00024	Glycolysis	P00676	Glyceraldehyde 3-phosphate dehydrogenase	HUMAN|HGNC=4141|UniProtKB=P04406	Glyceraldehyde-3-phosphate dehydrogenase	RCA			PTHR10836:SF51	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	CAEEL|WormBase=WBGene00004769|UniProtKB=P52166	Presenilin sel-12	TAS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	DANRE|ZFIN=ZDB-GENE-990415-29|UniProtKB=Q91398	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	IDA	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00748	Gbeta5L	HUMAN|HGNC=4401|UniProtKB=O14775	Guanine nucleotide-binding protein subunit beta-5	IDA	10051575	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00034	Integrin signalling pathway	P00948	Rho	HUMAN|HGNC=18314|UniProtKB=Q92730	Rho-related GTP-binding protein Rho6	IGI	11973360	PubMed	PTHR24072:SF23	RHO-RELATED GTP-BINDING PROTEIN RHO6
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00018	EGF receptor signaling pathway	P00548	RKIP	ARATH|TAIR=AT4G20370|UniProtKB=Q9S7R5	Protein TWIN SISTER of FT	ISS			PTHR11362:SF9	PROTEIN FLOWERING LOCUS T-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	CANLF|Gene=DRD2|UniProtKB=Q9GJU1	D(2) dopamine receptor	ISS	11248120	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	RAT|RGD=2089|UniProtKB=P05065	Fructose-bisphosphate aldolase A	ISS	74094688	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01173	STAT	MOUSE|MGI=MGI=103038|UniProtKB=P42227	Signal transducer and activator of transcription 3	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	RCA			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05731	GABA-B receptor II signaling	P05755	Gbeta	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	MOUSE|MGI=MGI=95815|UniProtKB=P39087	Glutamate receptor ionotropic, kainate 2	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TAKRU|Ensembl=ENSTRUG00000014318|UniProtKB=H2UI49	Uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	YEAST|SGD=S000002987|UniProtKB=P43639	Casein kinase II subunit beta	IDA	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	TAKRU|Ensembl=ENSTRUG00000005471|UniProtKB=H2SL56	Uncharacterized protein (Fragment)	ISS	12488551	PubMed	PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DROME|FlyBase=FBgn0000489|UniProtKB=P16912	Protein kinase DC2	IC	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	TAS	10747026	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	MACMU|Ensembl=ENSMMUG00000012005|UniProtKB=F7H091	Metabotropic glutamate receptor 2 isoform a	ISS	20012997	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00053	T cell activation	P01322	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g247341|UniProtKB=A7STP5	Predicted protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00034	Integrin signalling pathway	P00931	Integrin beta	HUMAN|Ensembl=ENSG00000259753|UniProtKB=H3BM21	Integrin beta (Fragment)	IDA	5805343	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00018	EGF receptor signaling pathway	P00539	14-3-3	CAEEL|WormBase=WBGene00003920|UniProtKB=P41932	14-3-3-like protein 1	IGI	22318813	PubMed	PTHR18860:SF21	14-3-3-LIKE PROTEIN 1
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DROME|FlyBase=FBgn0000046|UniProtKB=P10981	Actin-87E	IDA	14684598	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00513	Op18/stathmin	MOUSE|MGI=MGI=1931224|UniProtKB=P63042	Stathmin-4	ISS			PTHR10104:SF6	STATHMIN-4
P00003	Alzheimer disease-amyloid secretase pathway	P00108	ADAM10	HUMAN|HGNC=188|UniProtKB=O14672	Disintegrin and metalloproteinase domain-containing protein 10	IDA	12354787	PubMed	PTHR11905:SF4	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 10
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	7667318	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IGI	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00018	EGF receptor signaling pathway	P00551	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IGI	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00060	Ubiquitin proteasome pathway	P01491	E2	MACMU|Ensembl=ENSMMUG00000021023|UniProtKB=F7HGA9	Uncharacterized protein	ISS			PTHR44189:SF1	UBIQUITIN-CONJUGATING ENZYME E2 C
P00047	PDGF signaling pathway	P01143	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9836512	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	PHYPA|Gene=PHYPADRAFT_217733|UniProtKB=A9T0I0	Predicted protein	ISS			PTHR10410:SF5	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 14
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00921	PINCH	BOVIN|Ensembl=ENSBTAG00000006262|UniProtKB=Q2KJ33	LIM and senescent cell antigen-like-containing domain protein 2	ISS	10022929	PubMed	PTHR24210:SF10	LIM AND SENESCENT CELL ANTIGEN-LIKE-CONTAINING DOMAIN PROTEIN 2
P00060	Ubiquitin proteasome pathway	P01491	E2	HUMAN|HGNC=12482|UniProtKB=P62253	Ubiquitin-conjugating enzyme E2 G1	ISS			PTHR24067:SF3	UBIQUITIN-CONJUGATING ENZYME E2 G1
P00029	Huntington disease	P00796	Kainate receptor	XENTR|Xenbase=XB-GENE-957124|UniProtKB=F7BDN8	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00047	PDGF signaling pathway	P01173	STAT	DANRE|ZFIN=ZDB-GENE-980526-499|UniProtKB=Q6P943	Signal transducer and activator of transcription	ISS	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00054	Toll receptor signaling pathway	P01345	IKKalpha	MACMU|Ensembl=ENSMMUG00000018476|UniProtKB=F6X938	Uncharacterized protein	ISS	12235208	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	8838325	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00059	p53 pathway	P04609	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	RAT|RGD=621516|UniProtKB=G3V6P8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00010	B cell activation	P00371	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	RAT|RGD=69277|UniProtKB=P25108	Acetylcholine receptor subunit alpha	ISS	85270494	PubMed	PTHR18945:SF74	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05963	MAO	CANLF|Ensembl=ENSCAFG00000014435|UniProtKB=P58027	Amine oxidase [flavin-containing] A	ISS	8602220	PubMed	PTHR43563:SF3	AMINE OXIDASE  FLAVIN-CONTAINING  A
P00053	T cell activation	P01298	NFkappaB	HUMAN|HGNC=7795|UniProtKB=Q00653	Nuclear factor NF-kappa-B p100 subunit	IGI	12574369	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	RAT|RGD=3100|UniProtKB=P50280	Matrilysin	TAS	12834808	PubMed	PTHR10201:SF143	MATRILYSIN
P00036	Interleukin signaling pathway	P00996	STAT	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	12191995	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00030	Hypoxia response via HIF activation	P00819	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00778	NMDA receptor	DANRE|ZFIN=ZDB-GENE-051202-2|UniProtKB=Q6ZM67	Uncharacterized protein	ISS	14698601	PubMed	PTHR44391:SF3	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	ARATH|TAIR=AT2G23070|UniProtKB=O64816	Casein kinase II subunit alpha, chloroplastic	IDA	10617630	PubMed	PTHR24054:SF33	CASEIN KINASE II SUBUNIT ALPHA, CHLOROPLASTIC
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	RCA	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CANLF|Ensembl=ENSCAFG00000005662|UniProtKB=E2R907	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00048	PI3 kinase pathway	P01199	Galpha	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS			PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00059	p53 pathway	P04611	P300	HUMAN|HGNC=3373|UniProtKB=Q09472	Histone acetyltransferase p300	ISS	8413673	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00054	Toll receptor signaling pathway	P01375	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00056	VEGF signaling pathway	P01407	Erk	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	RAT|RGD=3564|UniProtKB=O08774	Regulator of G-protein signaling 12	IDA	8756726	PubMed	PTHR10845:SF149	REGULATOR OF G-PROTEIN SIGNALING 12
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P06664	Gonadotropin-releasing hormone receptor pathway	P06849	Sos	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	RCA	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00030	Hypoxia response via HIF activation	P00817	TOR	CRYNJ|EnsemblGenome=CNF03740|UniProtKB=Q5KEY7	Phosphatidylinositol 3-kinase TOR1	TAS	14526383	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00047	PDGF signaling pathway	P01150	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00034	Integrin signalling pathway	P00951	Jnk	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00019	Endothelin signaling pathway	P00591	PLCbeta	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	IGI	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	RAT|RGD=2364|UniProtKB=P11442	Clathrin heavy chain 1	IDA	9388255	PubMed	PTHR10292:SF7	CLATHRIN HEAVY CHAIN 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	DROME|FlyBase=FBgn0038980|UniProtKB=Q9VCZ3	Octopamine receptor beta-1R	IDA			PTHR43893:SF14	OCTOPAMINE RECEPTOR BETA-1R-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=109355|UniProtKB=O35526	Syntaxin-1A	ISS	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00047	PDGF signaling pathway	P01162	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00005	Angiogenesis	P00251	cPLA2	PANTR|Ensembl=ENSPTRG00000001787|UniProtKB=H2Q0T0	Phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04397	p53 pathway by glucose deprivation	P04641	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00052	TGF-beta signaling pathway	P01286	TGFbeta	RAT|RGD=1305994|UniProtKB=D3ZGK9	Nodal homolog (Mouse) (Predicted)	ISS	9759503	PubMed	PTHR11848:SF159	NODAL HOMOLOG
P00059	p53 pathway	P04609	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00060	Ubiquitin proteasome pathway	P01490	E3	MACMU|Ensembl=ENSMMUG00000017428|UniProtKB=F7HPQ2	Uncharacterized protein	ISS			PTHR10953:SF155	UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 1
P02721	ATP synthesis	P02798	Cyt C	MONDO|Ensembl=ENSMODG00000000653|UniProtKB=F6STW5	Uncharacterized protein	ISS	5933863	PubMed	PTHR11961:SF15	CYTOCHROME C
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	TAS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05916	Opioid prodynorphin pathway	P06000	vasopressin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-478663|UniProtKB=F7EG64	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	IDA	97102676	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00021	FGF signaling pathway	P00644	p38	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	IGI	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00005	Angiogenesis	P00223	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01304	Csk	CHICK|Gene=CSK|UniProtKB=P41239	Tyrosine-protein kinase CSK	IDA	12665526	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	HUMAN|HGNC=17780|UniProtKB=Q562R1	Beta-actin-like protein 2	IC	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00052	TGF-beta signaling pathway	P01275	P38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00005	Angiogenesis	P00247	Tie2	CANLF|Ensembl=ENSCAFG00000001713|UniProtKB=F1P8U6	Uncharacterized protein	ISS	1630810	PubMed	PTHR24416:SF125	ANGIOPOIETIN-1 RECEPTOR
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00521	Profilin	MONDO|Ensembl=ENSMODG00000021269|UniProtKB=F6T2V7	Profilin	ISS			PTHR13936:SF15	PROFILIN-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	PANTR|Ensembl=ENSPTRG00000009477|UniProtKB=H2QDK7	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00018	EGF receptor signaling pathway	P00552	Ras	XENTR|Xenbase=XB-GENE-494548|UniProtKB=F7EC26	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Ensembl=ENSGALG00000028749|UniProtKB=Q5ZMQ2	Actin, cytoplasmic 2	ISS	11889139	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00005	Angiogenesis	P00215	Nck	MACMU|Ensembl=ENSMMUG00000001390|UniProtKB=F7D094	Uncharacterized protein	ISS	12874226	PubMed	PTHR44108:SF1	CYTOPLASMIC PROTEIN NCK2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P06587	Nicotine pharmacodynamics pathway	P06590	GNG	PANTR|Ensembl=ENSPTRG00000006342|UniProtKB=H2Q8A8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=30035|UniProtKB=Q8WYR1	Phosphoinositide 3-kinase regulatory subunit 5	ISS	12507995	PubMed	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DICDI|dictyBase=DDB_G0277143|UniProtKB=P36408	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00219	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00053	T cell activation	P01331	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00053	T cell activation	P01332	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000016428|UniProtKB=F7GU00	Metabotropic glutamate receptor 1 isoform alpha	ISS			PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P06587	Nicotine pharmacodynamics pathway	P06613	CHRNB2	RAT|RGD=2350|UniProtKB=P12390	Neuronal acetylcholine receptor subunit beta-2	TAS	15155845	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P00018	EGF receptor signaling pathway	P00564	Rac	ORYSJ|EnsemblGenome=OS02G0120800|UniProtKB=Q6ZHA3	Rac-like GTP-binding protein 6	ISS	11950993	PubMed	PTHR24072:SF261	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00629	PP2A	CANLF|Ensembl=ENSCAFG00000014047|UniProtKB=F1PV54	Uncharacterized protein	ISS	96161994	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00774	Dynein complex	MACMU|Ensembl=ENSMMUG00000005915|UniProtKB=F6WW23	Uncharacterized protein	ISS	9454836	PubMed	PTHR12442:SF34	CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IC	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P02743	Formyltetrahydroformate biosynthesis	P02958	Dihydrofolate synthase	MYCTU|EnsemblGenome=LH57_13380|UniProtKB=I6Y0R5	Dihydrofolate synthase	ISS			PTHR11136:SF0	DIHYDROFOLATE SYNTHETASE-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00021	FGF signaling pathway	P00632	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	CHICK|Gene=FZD10|UniProtKB=Q9PWH2	Frizzled-10	TAS	11212302	PubMed	PTHR11309:SF86	FRIZZLED-10
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00001	Adrenaline and noradrenaline biosynthesis	P00068	amine translocator	CANLF|Ensembl=ENSCAFG00000019791|UniProtKB=J9NVM9	Transporter	ISS	12719981	PubMed	PTHR11616:SF102	SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER SLC6A17
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00018	EGF receptor signaling pathway	P00557	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_94959|UniProtKB=C3XYC4	Putative uncharacterized protein	IDA	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00053	T cell activation	P01306	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00036	Interleukin signaling pathway	P00990	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	9516481	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04392	P53 pathway feedback loops 1	G04684	Pirh-2	BOVIN|Ensembl=ENSBTAG00000007189|UniProtKB=A4IFE2	RCHY1 protein	ISS	607680	OMIM	PTHR21319:SF20	RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	XENTR|Xenbase=XB-GENE-6469705|UniProtKB=Q6P8G3	Actin, alpha sarcomeric/skeletal	ISS	11889139	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P05915	Opioid proenkephalin pathway	P05994	G-protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02746	Heme biosynthesis	P02972	Ferrochelatase	PANTR|Gene=FECH|UniProtKB=Q3YA36	Ferrochelatase, mitochondrial	ISS			PTHR11108:SF1	FERROCHELATASE, MITOCHONDRIAL
P00054	Toll receptor signaling pathway	P01381	Ubc13	XENTR|Xenbase=XB-GENE-943749|UniProtKB=F6W7A5	Uncharacterized protein	ISS			PTHR43902:SF2	UBIQUITIN-CONJUGATING ENZYME E2 N
P04395	Vasopressin synthesis	P04597	Signal Peptide	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	RAT|RGD=62010|UniProtKB=P34997	C-X-C chemokine receptor type 5	ISS	6680790	gi	PTHR10489:SF618	C-X-C CHEMOKINE RECEPTOR TYPE 5
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	ARATH|TAIR=AT5G35170|UniProtKB=Q8VYL1	Adenylate kinase 5, chloroplastic	ISS			PTHR23359:SF72	ADENYLATE KINASE 5, CHLOROPLASTIC
P00021	FGF signaling pathway	P00629	PP2A	BOVIN|Ensembl=ENSBTAG00000007061|UniProtKB=Q08DP7	Protein phosphatase 2, regulatory subunit B', beta isoform	ISS	11531413	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MONDO|Ensembl=ENSMODG00000024440|UniProtKB=F7DJJ2	Muscarinic acetylcholine receptor	ISS	10069496	PubMed	PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P04398	p53 pathway feedback loops 2	P04660	SIAH-1	BOVIN|Ensembl=ENSBTAG00000010868|UniProtKB=F1N5G3	E3 ubiquitin-protein ligase	ISS	14985507	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00010	B cell activation	P00374	Lyn	PANTR|Ensembl=ENSPTRG00000020263|UniProtKB=H2R453	Tyrosine-protein kinase	ISS	1371009	PubMed	PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	XENTR|Xenbase=XB-GENE-491618|UniProtKB=Q6P378	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	MACMU|Ensembl=ENSMMUG00000022893|UniProtKB=F6WF14	Uncharacterized protein	ISS	11583304	PubMed	PTHR11339:SF361	VON WILLEBRAND FACTOR-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	IDA	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	DANRE|ZFIN=ZDB-GENE-040718-134|UniProtKB=Q6DH55	Guanine nucleotide binding protein (G protein), beta polypeptide 3, like	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	G01580	p21	RAT|RGD=69328|UniProtKB=Q64315	Cyclin-dependent kinase inhibitor 1A	IGI	7774811	PubMed	PTHR10265:SF16	CYCLIN-DEPENDENT KINASE INHIBITOR 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BOVIN|Ensembl=ENSBTAG00000014614|UniProtKB=P62739	Actin, aortic smooth muscle	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	DROME|FlyBase=FBgn0010399|UniProtKB=Q24418	Glutamate [NMDA] receptor subunit 1	IC	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IGI	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	MOUSE|MGI=MGI=2388633|UniProtKB=Q68FD5	Clathrin heavy chain 1	ISS	9388255	PubMed	PTHR10292:SF7	CLATHRIN HEAVY CHAIN 1
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000005917|UniProtKB=F6QM53	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00018	EGF receptor signaling pathway	P00546	GAP	MOUSE|MGI=MGI=97306|UniProtKB=Q04690	Neurofibromin	IGI	95047432	PubMed	PTHR10194:SF60	NEUROFIBROMIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	9166716	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P02782	Triacylglycerol metabolism	P03205	Triacylglycerol lipase	MOUSE|MGI=MGI=96790|UniProtKB=P54310	Hormone-sensitive lipase	ISS			PTHR23025:SF3	HORMONE-SENSITIVE LIPASE
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00375	Calmodulin	HUMAN|HGNC=1442|UniProtKB=P62158	Calmodulin	IDA	3885394	PubMed	PTHR23050:SF311	CALMODULIN
P00036	Interleukin signaling pathway	P00975	RasGAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	ISS	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00006	Apoptosis signaling pathway	P00274	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	15528206	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05915	Opioid proenkephalin pathway	P05987	peptide F	DANRE|ZFIN=ZDB-GENE-030729-3|UniProtKB=F1QTD1	Uncharacterized protein (Fragment)	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P04393	Ras Pathway	P04542	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00025	Hedgehog signaling pathway	P00682	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00254	GTPase	MOUSE|MGI=MGI=106028|UniProtKB=Q62159	Rho-related GTP-binding protein RhoC	ISS	14871999	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00059	p53 pathway	P04633	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00910	Grb2	MACMU|Ensembl=ENSMMUG00000005327|UniProtKB=F7GJG7	GRB2-related adapter protein	ISS	8051109	PubMed	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P05915	Opioid proenkephalin pathway	P05994	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00034	Integrin signalling pathway	P00925	MEK	PANTR|Ensembl=ENSPTRG00000008783|UniProtKB=H2QCA7	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	DROME|FlyBase=FBgn0001105|UniProtKB=P26308	Guanine nucleotide-binding protein subunit beta-1	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00010	B cell activation	P00402	Jnk	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	ARATH|TAIR=AT3G19960|UniProtKB=Q9LHE9	Myosin-1	IC			PTHR13140:SF685	MYOSIN-1-RELATED
P00018	EGF receptor signaling pathway	P00552	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00029	Huntington disease	P00807	Actin	DANRE|ZFIN=ZDB-GENE-050417-267|UniProtKB=F1QUN8	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF263	ACTIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00045	Notch signaling pathway	P01105	TACE	MONDO|Ensembl=ENSMODG00000008735|UniProtKB=F6PTE7	Uncharacterized protein	ISS			PTHR11905:SF4	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 10
P00049	Parkinson disease	P01219	SAPK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	NAS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	ORNAN|Ensembl=ENSOANG00000003489|UniProtKB=F7FSE3	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	BOVIN|Ensembl=ENSBTAG00000011723|UniProtKB=E1BKL6	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02916	dTMP kinase	BACSU|EnsemblGenome=BSU00280|UniProtKB=P37537	Thymidylate kinase	ISS			PTHR10344:SF1	THYMIDYLATE KINASE
P04393	Ras Pathway	P04559	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00018	EGF receptor signaling pathway	P00554	Shc	MOUSE|MGI=MGI=106180|UniProtKB=Q8BMC3	SHC-transforming protein 2	ISS	600560	OMIM	PTHR10337:SF5	SHC-TRANSFORMING PROTEIN 2
P00021	FGF signaling pathway	P00632	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00006	Apoptosis signaling pathway	P00279	endoG	CANLF|Ensembl=ENSCAFG00000020036|UniProtKB=E2RQB6	Uncharacterized protein	ISS			PTHR13966:SF5	ENDONUCLEASE G, MITOCHONDRIAL
P00005	Angiogenesis	P00205	GAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00011	Blood coagulation	P00403	EPCR	MOUSE|MGI=MGI=104596|UniProtKB=Q64695	Endothelial protein C receptor	ISS	6755176	gi	PTHR15349:SF0	ENDOTHELIAL PROTEIN C RECEPTOR
P02738	De novo purine biosynthesis	P02908	Phosphoribosylamine glycine ligase	SCHPO|PomBase=SPBC405.01|UniProtKB=P20772	Bifunctional purine biosynthetic protein ADE1	ISS			PTHR10520:SF10	TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DICDI|dictyBase=DDB_G0279413|UniProtKB=P05987	cAMP-dependent protein kinase regulatory subunit	IC	92186968	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00059	p53 pathway	P04633	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01221	Torsin A	PANTR|Ensembl=ENSPTRG00000022599|UniProtKB=H2QZU6	Torsin family 1, member A (Torsin A)	ISS	12421356	PubMed	PTHR10760:SF15	TORSIN-1A
P02723	Adenine and hypoxanthine salvage pathway	P02812	Deoxyinosine phosphorylase	BOVIN|Ensembl=ENSBTAG00000012317|UniProtKB=P55859	Purine nucleoside phosphorylase	ISS	9585525	PubMed	PTHR11904:SF12	PURINE NUCLEOSIDE PHOSPHORYLASE
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	TAS	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00010	B cell activation	P00381	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P04376	5HT4 type receptor mediated signaling pathway	P04426	K+ channel	MOUSE|MGI=MGI=1100509|UniProtKB=O35111	Potassium channel subfamily K member 3	ISS	15282272	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CANLF|Ensembl=ENSCAFG00000005662|UniProtKB=E2R907	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00912	Arp2/3	DANRE|ZFIN=ZDB-GENE-040116-1|UniProtKB=Q7ZUQ0	Actin related protein 2/3 complex, subunit 1A	ISS	12932731	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00048	PI3 kinase pathway	P01188	Gbetagamma	BRAFL|Gene=BRAFLDRAFT_220697|UniProtKB=C3ZSF0	Putative uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00021	FGF signaling pathway	P00633	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02746	Heme biosynthesis	P02979	porphobilinogen synthase	HALSA|EnsemblGenome=VNG_2322G|UniProtKB=Q9HMZ1	Delta-aminolevulinic acid dehydratase	ISS			PTHR11458:SF0	DELTA-AMINOLEVULINIC ACID DEHYDRATASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF31	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01419	Ets	MACMU|Ensembl=ENSMMUG00000020706|UniProtKB=F6PU72	Uncharacterized protein	ISS	15699632	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06782	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	RCA	1504106	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01143	ERK	ORYSJ|Gene=Os01g0665200|UniProtKB=Q5SN53	Mitogen-activated protein kinase 8	ISS	15289849	gi	PTHR24055:SF219	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	XENTR|Xenbase=XB-GENE-6067221|UniProtKB=F6Z0J4	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	RAT|RGD=2929|UniProtKB=G3V7M2	Integrin beta	ISS	3487386	PubMed	PTHR10082:SF36	INTEGRIN BETA-7
P00006	Apoptosis signaling pathway	P00314	MKK3	MACMU|Ensembl=ENSMMUG00000010904|UniProtKB=F7GLY5	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	CHICK|Ensembl=ENSGALG00000028896|UniProtKB=R4GMK5	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF728	MYOSIN HEAVY CHAIN, SKELETAL MUSCLE, ADULT
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	YEAST|SGD=S000004689|UniProtKB=A2P2R3	Putative glutamine--fructose-6-phosphate aminotransferase [isomerizing]	ISS			PTHR10937:SF0	GH12731P-RELATED
P00048	PI3 kinase pathway	P01177	P110ACT	CAEEL|WormBase=WBGene00003965|UniProtKB=Q9Y1J3	3-phosphoinositide-dependent protein kinase 1	IC	10364160	PubMed	PTHR24356:SF309	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000001583|UniProtKB=F7BBM1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00056	VEGF signaling pathway	P01417	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IGI	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04397	p53 pathway by glucose deprivation	P04641	Akt	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	ISS	22084520	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05915	Opioid proenkephalin pathway	P05994	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	ARATH|TAIR=AT4G35290|UniProtKB=Q93YT1	Glutamate receptor 3.2	IC	12941441	PubMed	PTHR43891:SF18	GLUTAMATE RECEPTOR 3.1-RELATED
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	BRAFL|Gene=BRAFLDRAFT_283521|UniProtKB=C3XXY6	Putative uncharacterized protein	ISS	9727008	PubMed	PTHR10410:SF5	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 14
P04393	Ras Pathway	P04548	ATF2	BOVIN|Ensembl=ENSBTAG00000002295|UniProtKB=F1N177	Uncharacterized protein	ISS	11390664	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00006	Apoptosis signaling pathway	P00302	ATF	MONDO|Ensembl=ENSMODG00000009514|UniProtKB=F7EVK3	Uncharacterized protein	ISS	9819389	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P02783	Tryptophan biosynthesis	P03208	Tryptophan synthase B	AQUAE|EnsemblGenome=aq_1410|UniProtKB=O67409	Tryptophan synthase beta chain 2	ISS			PTHR43565:SF1	TRYPTOPHAN SYNTHASE BETA CHAIN
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	IDA	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00010	B cell activation	P00381	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00398	IP3R	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	IGI	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	CANLF|Ensembl=ENSCAFG00000006044|UniProtKB=F1Q223	Uncharacterized protein	ISS	11055438	PubMed	PTHR10117:SF25	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 4
P02752	Mannose metabolism	P03015	GDP-Mannose 4,6-dehydratase	PSEAE|EnsemblGenome=PA5453|UniProtKB=Q51366	GDP-mannose 4,6-dehydratase	TAS	10984043	PubMed	PTHR43715:SF1	GDP-MANNOSE 4,6 DEHYDRATASE
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05915	Opioid proenkephalin pathway	P05990	K+ channel	MOUSE|MGI=MGI=1100509|UniProtKB=O35111	Potassium channel subfamily K member 3	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00060	Ubiquitin proteasome pathway	P01491	E2	MONDO|Ensembl=ENSMODG00000013897|UniProtKB=F6VSA5	Uncharacterized protein (Fragment)	ISS			PTHR24068:SF24	UBIQUITIN-CONJUGATING ENZYME E2 D4
P05731	GABA-B receptor II signaling	P05760	AC	MACMU|Ensembl=ENSMMUG00000006421|UniProtKB=F6U2K7	Uncharacterized protein	ISS	89298382	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01199	Galpha	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05913	Enkephalin release	P05978	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IGI	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	PANTR|Ensembl=ENSPTRG00000020210|UniProtKB=Q5IS76	Neuronal acetylcholine receptor subunit alpha-6	ISS	85270494	PubMed	PTHR18945:SF82	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-6
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00979	MAPKAPK2	HUMAN|HGNC=6887|UniProtKB=P49137	MAP kinase-activated protein kinase 2	IDA	7923354	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	TAS	12736250	PubMed	PTHR10202:SF18	PRESENILIN-1
P00034	Integrin signalling pathway	P00927	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	RAT|RGD=1309514|UniProtKB=D4AA42	Guanine nucleotide binding protein, alpha transducing 2 (Predicted), isoform CRA_b	ISS	12488551	PubMed	PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P00059	p53 pathway	P04633	P110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00540	MKK3,6	ORNAN|Ensembl=ENSOANG00000007732|UniProtKB=F6PXH5	Uncharacterized protein (Fragment)	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00006	Apoptosis signaling pathway	P00322	Cytochrome C	MACMU|Ensembl=ENSMMUG00000032138|UniProtKB=F7GRC6	Uncharacterized protein	ISS	4954366	PubMed	PTHR11961:SF15	CYTOCHROME C
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P05731	GABA-B receptor II signaling	P05752	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P02747	Histidine biosynthesis	P02992	Imidazol glycerol phosphate synthase	BACTN|EnsemblGenome=BT_1378|UniProtKB=Q8A7Z6	Imidazole glycerol phosphate synthase subunit HisF	ISS			PTHR21235:SF2	IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00729	Goalpha	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00059	p53 pathway	P04630	PP2A	MOUSE|MGI=MGI=1321159|UniProtKB=P63330	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00049	Parkinson disease	P01211	ERK	HUMAN|HGNC=24667|UniProtKB=Q8TD08	Mitogen-activated protein kinase 15	IDA	10851062	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CHICK|Ensembl=ENSGALG00000008898|UniProtKB=F1P2J9	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000001014|UniProtKB=A5PKJ4	Mitogen-activated protein kinase 7	ISS	15085193	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00021	FGF signaling pathway	P00636	FGFR1-4	MOUSE|MGI=MGI=95523|UniProtKB=P21803	Fibroblast growth factor receptor 2	IGI	14507786	PubMed	PTHR24416:SF130	FIBROBLAST GROWTH FACTOR RECEPTOR 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PANTR|Ensembl=ENSPTRG00000006890|UniProtKB=H2Q943	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00005	Angiogenesis	P00219	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02754	Methylcitrate cycle	P03028	Aconitase	MONDO|Ensembl=ENSMODG00000011768|UniProtKB=F7CW14	Uncharacterized protein	ISS			PTHR11670:SF31	IRON-RESPONSIVE ELEMENT-BINDING PROTEIN 2
P00019	Endothelin signaling pathway	P00568	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00059	p53 pathway	G04694	p110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	DROME|FlyBase=FBgn0001105|UniProtKB=P26308	Guanine nucleotide-binding protein subunit beta-1	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00518	Rho GEFs	PANTR|Ensembl=ENSPTRG00000011039|UniProtKB=H2QGF2	Uncharacterized protein	ISS	12123608	PubMed	PTHR12673:SF122	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01094	gamma	XENTR|Xenbase=XB-GENE-990010|UniProtKB=F6WX69	Uncharacterized protein (Fragment)	ISS	95224005	PubMed	PTHR18945:SF60	ACETYLCHOLINE RECEPTOR SUBUNIT GAMMA
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	9514948	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	GIAIC|EnsemblGenome=GL50803_40817|UniProtKB=A8BV70	Actin related protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00034	Integrin signalling pathway	P00923	Arf1	IXOSC|EnsemblGenome=ISCW022927|UniProtKB=B7QCW2	ADP-ribosylation factor	ISS	11752622	PubMed	PTHR11711:SF304	ADP-RIBOSYLATION FACTOR 1
P00049	Parkinson disease	P01211	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00922	Collagen	PANTR|Ensembl=ENSPTRG00000018033|UniProtKB=H2R4E0	Uncharacterized protein	ISS	10778855	PubMed	PTHR24023:SF509	COLLAGEN ALPHA-2 XI  CHAIN
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05731	GABA-B receptor II signaling	P05760	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	RCA	96149441	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P05912	Dopamine receptor mediated signaling pathway	P05944	COMT	MOUSE|MGI=MGI=88470|UniProtKB=O88587	Catechol O-methyltransferase	ISS	12842307	PubMed	PTHR43836:SF3	CATECHOL O-METHYLTRANSFERASE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P06664	Gonadotropin-releasing hormone receptor pathway	P06827	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	RCA	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00020	FAS signaling pathway	P00615	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	MONDO|Ensembl=ENSMODG00000002847|UniProtKB=F7B627	Uncharacterized protein (Fragment)	ISS	11907044	PubMed	PTHR44025:SF7	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DANRE|ZFIN=ZDB-GENE-000329-3|UniProtKB=Q7ZVF9	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00049	Parkinson disease	P01232	CASK	TAKRU|Ensembl=ENSTRUG00000011655|UniProtKB=H2TXP5	Uncharacterized protein	ISS	11679592	PubMed	PTHR23122:SF40	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	SCHPO|PomBase=SPBP35G2.05c|UniProtKB=P40234	Casein kinase I homolog 2	IDA	11437445	PubMed	PTHR11909:SF155	GILGAMESH, ISOFORM L
P00010	B cell activation	P00385	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00036	Interleukin signaling pathway	P00983	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00018	EGF receptor signaling pathway	P00546	GAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	IGI	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01173	STAT	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	14755057	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00021	FGF signaling pathway	P00629	PP2A	CANLF|Ensembl=ENSCAFG00000010882|UniProtKB=F1PX98	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B	ISS			PTHR11871:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B DELTA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CAEEL|WormBase=WBGene00002189|UniProtKB=P21137	cAMP-dependent protein kinase catalytic subunit	IC	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04398	p53 pathway feedback loops 2	P04665	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00912	Arp2/3	PANTR|Ensembl=ENSPTRG00000033819|UniProtKB=H2QV00	Actin related protein 2/3 complex, subunit 1A, 41kDa	ISS	12963527	gi	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00005	Angiogenesis	P00193	SOS-1	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	HUMAN|HGNC=14357|UniProtKB=Q8N119	Matrix metalloproteinase-21	TAS	12834808	PubMed	PTHR10201:SF147	MATRIX METALLOPROTEINASE-21
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02723	Adenine and hypoxanthine salvage pathway	P02811	Adenosine deaminase	SCHPO|PomBase=SPBC1683.02|UniProtKB=Q9P6J8	Uncharacterized deaminase C1683.02	ISS			PTHR43114:SF1	SUBFAMILY NOT NAMED
P00020	FAS signaling pathway	P00615	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02918	dUTP pyrophosphatase	CAEEL|WormBase=WBGene00010609|UniProtKB=G5EET2	DeoxyUTPase	ISS			PTHR11241:SF0	BCDNA.LD08534
P00054	Toll receptor signaling pathway	G01550	Gene trancription	PANTR|Ensembl=ENSPTRG00000001786|UniProtKB=H2Q0S9	Prostaglandin-endoperoxide synthase 2 (Prostaglandin G/H synthase and cyclooxygenase)	ISS	11861541	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P00021	FGF signaling pathway	P00624	14-3-3	CANLF|Ensembl=ENSCAFG00000007716|UniProtKB=E2QZT7	Uncharacterized protein	ISS	93387487	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00053	T cell activation	P01316	MHC-antigen	MACMU|Ensembl=ENSMMUG00000020158|UniProtKB=B5M475	MHC class II antigen	ISS	73139	PubMed	PTHR19944:SF59	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DQ ALPHA 1 CHAIN
P00029	Huntington disease	P00778	NMDA receptor	MOUSE|MGI=MGI=95822|UniProtKB=Q01098	Glutamate receptor ionotropic, NMDA 2C	IDA	11319238	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P05731	GABA-B receptor II signaling	P05752	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	CHICK|Ensembl=ENSGALG00000003498|UniProtKB=Q5ZMS1	Transcription initiation factor TFIID subunit 8	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00021	FGF signaling pathway	P00638	PLCgamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00053	T cell activation	P01311	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00648	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00053	T cell activation	P01307	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	HUMAN|HGNC=4588|UniProtKB=O15399	Glutamate receptor ionotropic, NMDA 2D	IC	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2D.html	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	MOUSE|MGI=MGI=107471|UniProtKB=P31695	Neurogenic locus notch homolog protein 4	IDA	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P00053	T cell activation	P01322	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MONDO|Ensembl=ENSMODG00000013079|UniProtKB=F7FB74	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00048	PI3 kinase pathway	P01196	PDK1	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	IGI	15531926	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04393	Ras Pathway	P04558	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00060	Ubiquitin proteasome pathway	P01491	E2	PANTR|Ensembl=ENSPTRG00000022225|UniProtKB=H2QZ18	Ubiquitin-conjugating enzyme E2A (RAD6 homolog)	ISS			PTHR43898:SF4	UBIQUITIN-CONJUGATING ENZYME E2 A
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00006	Apoptosis signaling pathway	P00313	IKK	MOUSE|MGI=MGI=1338071|UniProtKB=O88351	Inhibitor of nuclear factor kappa-B kinase subunit beta	IDA	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	TAS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00542	EGFR	HUMAN|HGNC=3431|UniProtKB=P21860	Receptor tyrosine-protein kinase erbB-3	ISS	20477399	gi	PTHR24416:SF88	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=4595|UniProtKB=Q14832	Metabotropic glutamate receptor 3	IDA	12488551	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	TAKRU|Ensembl=ENSTRUG00000009259|UniProtKB=H2TF39	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P02748	Isoleucine biosynthesis	P02997	Acetolactate synthase	SULSO|EnsemblGenome=SSO2962|UniProtKB=Q97UP3	Acetolactate synthase large subunit homolog (IlvB-5)	ISS			PTHR42981:SF2	PYRUVATE DEHYDROGENASE  UBIQUINONE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00054	Toll receptor signaling pathway	P01375	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00056	VEGF signaling pathway	P01425	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	MOUSE|MGI=MGI=87977|UniProtKB=Q9R0Y5	Adenylate kinase isoenzyme 1	ISS			PTHR23359:SF59	ADENYLATE KINASE ISOENZYME 1
P00057	Wnt signaling pathway	P01438	PP2A	MACMU|Ensembl=ENSMMUG00000020819|UniProtKB=F7HSM1	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01149	MNK1/2	RAT|RGD=1559603|UniProtKB=Q4G050	MAP kinase-interacting serine/threonine-protein kinase 1	ISS	9155018	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	RCA	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P02762	Pentose phosphate pathway	P03081	Transaldolase	AQUAE|EnsemblGenome=aq_119|UniProtKB=O66520	Probable transaldolase	IEA			PTHR10683:SF18	TRANSALDOLASE
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	IC	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00057	Wnt signaling pathway	P01451	Galpha	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	IDA	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	DROME|FlyBase=FBgn0028875|UniProtKB=Q7KT97	Nicotinic acetylcholine receptor alpha5, isoform B	IC	85270494	PubMed	PTHR18945:SF770	NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA5, ISOFORM B
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00034	Integrin signalling pathway	P00916	Ras	XENTR|Xenbase=XB-GENE-494548|UniProtKB=F7EC26	Uncharacterized protein	ISS	20362513	PubMed	PTHR24070:SF186	GTPASE KRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IDA	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	DROME|FlyBase=FBgn0034921|UniProtKB=Q9W1H5	Decapping protein 1, isoform A	ISS			PTHR16290:SF0	DECAPPING PROTEIN 1, ISOFORM A
P00059	p53 pathway	P01485	p53	CANLF|Gene=TP53|UniProtKB=Q29537	Cellular tumor antigen p53	TAS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00053	T cell activation	P01330	IKK	RAT|RGD=621375|UniProtKB=Q9QY78	Inhibitor of nuclear factor kappa-B kinase subunit beta	IGI	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00010	B cell activation	P00373	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04373	5HT1 type receptor mediated signaling pathway	P04407	K+ channel	MONDO|Ensembl=ENSMODG00000015769|UniProtKB=F6ZSC2	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00010	B cell activation	P00385	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04393	Ras Pathway	P04556	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00015	Circadian clock system	G01497	cry	MACMU|Ensembl=ENSMMUG00000021808|UniProtKB=F7ENG9	Cryptochrome-1	ISS	14507900	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00045	Notch signaling pathway	P01113	Pen-2	DANRE|ZFIN=ZDB-GENE-000330-9|UniProtKB=Q90ZE4	Presenilin-2	IEP	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	TAS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MACMU|Ensembl=ENSMMUG00000005586|UniProtKB=F7G4I3	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF115	RIBOSOMAL PROTEIN S6 KINASE ALPHA-5
P00056	VEGF signaling pathway	P01425	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00053	T cell activation	P01330	IKK	MOUSE|MGI=MGI=99484|UniProtKB=Q60680	Inhibitor of nuclear factor kappa-B kinase subunit alpha	IGI	12235208	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00925	MEK	ORNAN|Ensembl=ENSOANG00000007732|UniProtKB=F6PXH5	Uncharacterized protein (Fragment)	ISS	11971971	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00057	Wnt signaling pathway	P01435	SWI/SNF	CAEEL|WormBase=WBGene00004203|UniProtKB=H8ESF3	SWI/SNF nucleosome remodeling complex component	IDA	11532957	PubMed	PTHR12802:SF41	BRAHMA ASSOCIATED PROTEIN 155 KDA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Gene=PKN1|UniProtKB=A1A4I4	Serine/threonine-protein kinase N1	ISS	11554554	PubMed	PTHR24356:SF246	SERINE/THREONINE-PROTEIN KINASE N1
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IGI	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00057	Wnt signaling pathway	P01449	Nemo-like Kinase	DANRE|ZFIN=ZDB-GENE-080320-1|UniProtKB=E7F1L8	Mitogen-activated protein kinase	ISS	10683140	PubMed	PTHR24055:SF179	SERINE/THREONINE-PROTEIN KINASE NLK
P05730	Endogenous cannabinoid signaling	P05743	CB1	CHICK|Ensembl=ENSGALG00000015789|UniProtKB=F1NJC1	Uncharacterized protein	ISS	114610	OMIM	PTHR22750:SF47	CANNABINOID RECEPTOR 1
P00019	Endothelin signaling pathway	P00566	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00010	B cell activation	P00391	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	TAKRU|Ensembl=ENSTRUG00000011169|UniProtKB=H2TU36	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00036	Interleukin signaling pathway	P00973	PKB	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_58093|UniProtKB=C3Z4K3	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00036	Interleukin signaling pathway	P00985	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	15531926	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	PANTR|Ensembl=ENSPTRG00000006510|UniProtKB=H2Q8K1	Presenilin	ISS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00034	Integrin signalling pathway	P00925	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00019	Endothelin signaling pathway	P00572	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00057	Wnt signaling pathway	P01471	alpha-catenin	BOVIN|Gene=CTNNA1|UniProtKB=Q3MHM6	Catenin alpha-1	ISS	10456847	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=107434|UniProtKB=P97291	Cadherin-8	IDA	8120095	PubMed	PTHR24027:SF273	CADHERIN-8
P00004	Alzheimer disease-presenilin pathway	P00147	TACE	PANTR|Ensembl=ENSPTRG00000011640|UniProtKB=H2R900	Uncharacterized protein	ISS	9774383	PubMed	PTHR11905:SF171	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17
P02736	Coenzyme A biosynthesis	P02886	Pantetheine-phosphate adenyltransferase	METAC|EnsemblGenome=MA_3546|UniProtKB=Q8TK70	Phosphopantetheine adenylyltransferase	ISS			PTHR10695:SF25	BIFUNCTIONAL PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE-DEPHOSPHO-COA KINASE
P00005	Angiogenesis	P00238	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00037	Ionotropic glutamate receptor pathway	P01026	KA	PANTR|Gene=GRIK4|UniProtKB=Q5IS46	Glutamate receptor ionotropic, kainate 4	ISS	12941441	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00830	Lipoxygenase	PANTR|Ensembl=ENSPTRG00000008597|UniProtKB=H2QBX9	Uncharacterized protein	ISS	12432925	PubMed	PTHR11771:SF33	ARACHIDONATE 15-LIPOXYGENASE
P00053	T cell activation	P01311	Raf	MOUSE|MGI=MGI=88190|UniProtKB=P28028	Serine/threonine-protein kinase B-raf	IDA	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00015	Circadian clock system	G01500	bmal1	TAKRU|Ensembl=ENSTRUG00000008391|UniProtKB=H2T8M1	Uncharacterized protein	ISS			PTHR23042:SF52	ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 1
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00925	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IDA	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04393	Ras Pathway	P04541	p90RSK	HUMAN|HGNC=10430|UniProtKB=Q15418	Ribosomal protein S6 kinase alpha-1	ISS	15226426	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00047	PDGF signaling pathway	P01173	STAT	DANRE|ZFIN=ZDB-GENE-040818-1|UniProtKB=F1QWX2	Signal transducer and activator of transcription	ISS	102582	OMIM	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	PANTR|Ensembl=ENSPTRG00000017965|UniProtKB=Q8HZD9	Tumor necrosis factor	ISS	11911478	PubMed	PTHR11471:SF23	TUMOR NECROSIS FACTOR
P00012	Cadherin signaling pathway	P00475	Frizzled	HUMAN|HGNC=4046|UniProtKB=Q9H461	Frizzled-8	IDA	11212302	PubMed	PTHR11309:SF90	FRIZZLED-8
P00053	T cell activation	P01329	CD45	PANTR|Ensembl=ENSPTRG00000001817|UniProtKB=H2Q0U9	Uncharacterized protein	ISS	8940015	PubMed	PTHR19134:SF284	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Gene=PCDHB5|UniProtKB=Q5DRC9	Protocadherin beta-5	ISS	8120095	PubMed	PTHR24028:SF90	PROTOCADHERIN BETA-5
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000022548|UniProtKB=F6Y9J9	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04395	Vasopressin synthesis	P04596	Endo Peptidase	ARATH|TAIR=AT1G76140|UniProtKB=F4I2A0	Prolyl oligopeptidase	IC	9695945	PubMed	PTHR42881:SF2	PROLYL ENDOPEPTIDASE
P02723	Adenine and hypoxanthine salvage pathway	P02812	Deoxyinosine phosphorylase	BACSU|EnsemblGenome=BSU23490|UniProtKB=P46354	Purine nucleoside phosphorylase 1	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00269	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00629	PP2A	XENTR|Xenbase=XB-GENE-957248|UniProtKB=Q6GLE6	Serine/threonine-protein phosphatase	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05913	Enkephalin release	P05974	G-Protein (i)	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00047	PDGF signaling pathway	P01171	PLCgamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00646	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	8262392	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04657	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	G01579	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00034	Integrin signalling pathway	P00925	MEK	CANLF|Ensembl=ENSCAFG00000017851|UniProtKB=F1PBB6	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00047	PDGF signaling pathway	P01151	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00053	T cell activation	P01336	Jnk	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00572	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00012	Cadherin signaling pathway	P00475	Frizzled	CHICK|Gene=FZD7|UniProtKB=O57329	Frizzled-7	IDA	11212302	PubMed	PTHR11309:SF31	FRIZZLED-7
P00034	Integrin signalling pathway	P00927	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	IGI	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00034	Integrin signalling pathway	P00931	Integrin beta	RAT|RGD=1560635|UniProtKB=Q5PQQ8	Integrin beta-like protein 1	ISS	3487386	PubMed	PTHR10082:SF3	INTEGRIN BETA-LIKE PROTEIN 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	ORYSJ|EnsemblGenome=OS03G0747900|UniProtKB=Q0DNL1	Os03g0747900 protein (Fragment)	IC			PTHR13140:SF270	MYOSIN-12
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	CANLF|Ensembl=ENSCAFG00000007780|UniProtKB=F1PZH9	Uncharacterized protein	ISS	11701344	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00053	T cell activation	P01332	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IDA	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00006	Apoptosis signaling pathway	P00313	IKK	RAT|RGD=1306661|UniProtKB=G3V926	Conserved helix-loop-helix ubiquitous kinase (Predicted)	ISS	12235208	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IDA	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00017	DNA replication	P00533	Pol delta	MACMU|Ensembl=ENSMMUG00000002423|UniProtKB=F6PLY1	DNA polymerase delta subunit 2	ISS	96079106	PubMed	PTHR10416:SF0	DNA POLYMERASE DELTA SUBUNIT 2
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=2136018|UniProtKB=Q9QYS1	Protein Wnt-16	IDA	11266476	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P02738	De novo purine biosynthesis	P02906	N5-carboxyaminoimidazole ribonucleotide synthase	DEIRA|EnsemblGenome=DR_0023|UniProtKB=Q9RYC7	N5-carboxyaminoimidazole ribonucleotide mutase	ISS			PTHR23046:SF2	N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE MUTASE
P00057	Wnt signaling pathway	P01451	Galpha	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	IDA	1333286	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00010	B cell activation	P00376	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00005	Angiogenesis	P00238	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00021	FGF signaling pathway	P00629	PP2A	XENTR|Xenbase=XB-GENE-484003|UniProtKB=Q6P365	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00018	EGF receptor signaling pathway	P00551	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04658	PTEN	XENTR|Xenbase=XB-GENE-491433|UniProtKB=B1H2U0	Pten protein	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00010	B cell activation	P00379	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02721	ATP synthesis	P02798	Cyt C	MACMU|Ensembl=ENSMMUG00000016443|UniProtKB=F7GTP8	Uncharacterized protein	ISS	4954366	PubMed	PTHR11961:SF15	CYTOCHROME C
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CANLF|Ensembl=ENSCAFG00000012181|UniProtKB=F2Z4N7	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00036	Interleukin signaling pathway	P00996	STAT	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00013	Cell cycle	P00480	Proteasome	BOVIN|Ensembl=ENSBTAG00000019918|UniProtKB=E1BM26	Uncharacterized protein	ISS	9218537	PubMed	PTHR10660:SF4	PROTEASOME ACTIVATOR COMPLEX SUBUNIT 3
P00034	Integrin signalling pathway	P00919	Arf6	HUMAN|HGNC=659|UniProtKB=P62330	ADP-ribosylation factor 6	IPI	11752622	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00010	B cell activation	P00401	jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00005	Angiogenesis	P00181	SHP2	HUMAN|HGNC=9658|UniProtKB=P29350	Tyrosine-protein phosphatase non-receptor type 6	ISS			PTHR19134:SF65	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 6
P00053	T cell activation	P01332	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IDA	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000002339|UniProtKB=H2R368	Uncharacterized protein	ISS	20088160	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	10395542	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00021	FGF signaling pathway	P00627	ERK1-2	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00057	Wnt signaling pathway	P01443	Phospholipase C	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05731	GABA-B receptor II signaling	P05754	Ggamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00052	TGF-beta signaling pathway	P01284	JNK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	TAS	10851062	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00034	Integrin signalling pathway	P00925	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00036	Interleukin signaling pathway	P00996	STAT	HUMAN|HGNC=11366|UniProtKB=P42229	Signal transducer and activator of transcription 5A	IDA	95236292	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00059	p53 pathway	P04633	P110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00006	Apoptosis signaling pathway	P00274	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05913	Enkephalin release	P05972	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04668	p53	PANTR|Ensembl=ENSPTRG00000008703|UniProtKB=H2QC53	Cellular tumor antigen p53	ISS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014555|UniProtKB=F7GT55	Syntaxin-1A isoform 1	ISS	1321498	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00059	p53 pathway	P04633	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	IDA	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00047	PDGF signaling pathway	P01164	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	9094314	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00005	Angiogenesis	P00201	FVIIa	DANRE|ZFIN=ZDB-GENE-010814-1|UniProtKB=F1QFP3	Uncharacterized protein	ISS	18858363	gi	PTHR44064:SF1	COAGULATION FACTOR VII
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	BOVIN|Ensembl=ENSBTAG00000020079|UniProtKB=F1N3T0	Uncharacterized protein	ISS	12878610	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PHYPA|Gene=PHYPADRAFT_110341|UniProtKB=Q6TYR6	Beta-tubulin 2	ISS	9454836	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IC	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	CANLF|Ensembl=ENSCAFG00000020380|UniProtKB=E2REX1	Uncharacterized protein	ISS			PTHR23359:SF79	ADENYLATE KINASE ISOENZYME 5
P04393	Ras Pathway	P04574	PLD	MACMU|Ensembl=ENSMMUG00000005666|UniProtKB=F6VWY6	Uncharacterized protein	ISS	12615079	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P00006	Apoptosis signaling pathway	P00274	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00053	T cell activation	P01306	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04496	Mdm2	PANTR|Ensembl=ENSPTRG00000001889|UniProtKB=H2R875	Mdm4 p53 binding protein homolog	ISS			PTHR13844:SF20	PROTEIN MDM4
P00057	Wnt signaling pathway	P01428	Frizzled	MACMU|Ensembl=ENSMMUG00000019399|UniProtKB=F6QFJ6	Frizzled-6	ISS	11212302	PubMed	PTHR11309:SF75	FRIZZLED-6
P00022	General transcription by RNA polymerase I	P00650	TAF-IB	DROME|FlyBase=FBgn0002842|UniProtKB=Q9VP40	Spermatocyte arrest	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00010	B cell activation	P00383	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00019	Endothelin signaling pathway	P00578	eNOS	BOVIN|Gene=NOS3|UniProtKB=P29473	Nitric oxide synthase, endothelial	IGI	93055452	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02756	N-acetylglucosamine metabolism	P03041	Glucosamine-6-phosphate deaminase	MACMU|Ensembl=ENSMMUG00000009273|UniProtKB=F7H603	Glucosamine-6-phosphate isomerase	ISS			PTHR11280:SF9	GLUCOSAMINE-6-PHOSPHATE ISOMERASE 2
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MOUSE|MGI=MGI=102522|UniProtKB=Q8R3Z5	Voltage-dependent L-type calcium channel subunit beta-1	IC	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00892	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	8051109	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00010	B cell activation	P00381	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01333	cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00049	Parkinson disease	P01219	SAPK	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	TAS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	PANTR|Ensembl=ENSPTRG00000008026|UniProtKB=H2QAZ2	Syntaxin 1B	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P02726	Aminobutyrate degradation	P02825	4-aminobutyrate aminotransferase	PYRAE|EnsemblGenome=PAE1799|UniProtKB=Q8ZWG5	4-aminobutyrate aminotransferase	ISS			PTHR11986:SF58	ALANINE--GLYOXYLATE AMINOTRANSFERASE 2, MITOCHONDRIAL
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	AQUAE|EnsemblGenome=aq_1334|UniProtKB=O67353	CTP synthase	ISS			PTHR11550:SF0	CTP SYNTHASE
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CAEBR|Gene=CBG02401|UniProtKB=A8WUE7	Protein CBR-NMR-1	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MOUSE|MGI=MGI=87905|UniProtKB=P68033	Actin, alpha cardiac muscle 1	IC	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00037	Ionotropic glutamate receptor pathway	P01018	Glu1	HUMAN|HGNC=4571|UniProtKB=P42261	Glutamate receptor 1	ISS	12941441	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	PHYPA|Gene=PHYPADRAFT_170715|UniProtKB=A9TLC7	Rop-family small GTPase	ISS	20556159	PubMed	PTHR24072:SF194	RAC-LIKE GTP-BINDING PROTEIN ARAC4-RELATED
P00056	VEGF signaling pathway	P01420	FAK	PANTR|Ensembl=ENSPTRG00000020624|UniProtKB=H2QWS1	Uncharacterized protein	ISS	12640026	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00056	VEGF signaling pathway	P01407	Erk	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04393	Ras Pathway	P04556	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02727	Androgen/estrogene/progesterone biosynthesis	P02826	Estradiol 17beta-dehydrogenase	HUMAN|HGNC=5211|UniProtKB=P37059	Estradiol 17-beta-dehydrogenase 2	RCA			PTHR43313:SF3	ESTRADIOL 17-BETA-DEHYDROGENASE 2
P02757	O-antigen biosynthesis	P03049	Glucosamine-1-phosphate acetyltransferase	SYNY3|EnsemblGenome=BAA10856|UniProtKB=Q55504	Bifunctional protein GlmU	ISS			PTHR43584:SF3	BIFUNCTIONAL PROTEIN GLMU
P02763	Peptidoglycan biosynthesis	P03087	Glutamate racemase	BACSU|EnsemblGenome=BSU28390|UniProtKB=P94556	Glutamate racemase 1	ISS			PTHR21198:SF2	GLUTAMATE RACEMASE
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ORYSJ|EnsemblGenome=OS02G0600100|UniProtKB=Q6K5H9	Os02g0600100 protein	ISS			PTHR14145:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MACMU|Ensembl=ENSMMUG00000022808|UniProtKB=F6UWC3	Actin-related protein 2/3 complex subunit 2	ISS	12473693	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00034	Integrin signalling pathway	P00922	Collagen	BOVIN|Ensembl=ENSBTAG00000011802|UniProtKB=E1BI98	Uncharacterized protein	ISS	10778855	PubMed	PTHR44172:SF3	COLLAGEN ALPHA-1 VI  CHAIN
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DANRE|ZFIN=ZDB-GENE-030131-55|UniProtKB=Q6XNL8	Actin	ISS	14684598	PubMed	PTHR11937:SF263	ACTIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	PANTR|Ensembl=ENSPTRG00000006342|UniProtKB=H2Q8A8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00011	Blood coagulation	P00443	Fibrin polymer cross-linked	BOVIN|Gene=FGG|UniProtKB=P12799	Fibrinogen gamma-B chain	ISS	89366676	PubMed	PTHR19143:SF338	FIBRINOGEN GAMMA CHAIN
P06664	Gonadotropin-releasing hormone receptor pathway	P06850	PKCs(3)	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	RCA	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00060	Ubiquitin proteasome pathway	P01490	E3	HUMAN|HGNC=6973|UniProtKB=Q00987	E3 ubiquitin-protein ligase Mdm2	ISS	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00021	FGF signaling pathway	P00626	Spry	MOUSE|MGI=MGI=1345144|UniProtKB=Q9WTP2	Protein sprouty homolog 4	ISS	12027893	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IC	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00640	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00014	Cholesterol biosynthesis	P00491	Hydroxymethyl glutaryl CoA reductase	PANTR|Ensembl=ENSPTRG00000016994|UniProtKB=H2QR35	3-hydroxy-3-methylglutaryl coenzyme A reductase	ISS	Q29512	SPACC	PTHR10572:SF2	3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE
P00010	B cell activation	P00379	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04393	Ras Pathway	P04570	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06786	ERK1/2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	RCA	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	BOVIN|Ensembl=ENSBTAG00000037985|UniProtKB=F1MCK3	Muscarinic acetylcholine receptor	ISS	12181435	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00048	PI3 kinase pathway	P01177	P110ACT	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	CANLF|Ensembl=ENSCAFG00000000807|UniProtKB=Q9GL27	Brachyury protein	IEP	12356903	PubMed	PTHR11267:SF83	BRACHYURY PROTEIN
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00059	p53 pathway	P04625	Cdk2	DANRE|ZFIN=ZDB-GENE-040426-2741|UniProtKB=Q7ZWB1	Cyclin-dependent kinase 2	ISS	15660127	PubMed	PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P00057	Wnt signaling pathway	P01434	sFRP	CHICK|Gene=SFRP1|UniProtKB=Q9DEQ4	Secreted frizzled-related protein 1	IDA	9096311	PubMed	PTHR11309:SF87	SECRETED FRIZZLED-RELATED PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	SCLS1|Gene=SS1G_08733|UniProtKB=A7ETS6	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00019	Endothelin signaling pathway	P00591	PLCbeta	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MACMU|Ensembl=ENSMMUG00000019112|UniProtKB=F6T8S6	N-methyl D-aspartate receptor subtype 2B	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00021	FGF signaling pathway	P00633	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00037	Ionotropic glutamate receptor pathway	P01023	CaMKII	MOUSE|MGI=MGI=88257|UniProtKB=P28652	Calcium/calmodulin-dependent protein kinase type II subunit beta	ISS	12888804	PubMed	PTHR43940:SF3	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00005	Angiogenesis	P00203	Erk	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02770	Pyridoxal phosphate salvage pathway	P03122	Pyridoxamine kinase	ARATH|TAIR=AT5G37850|UniProtKB=Q8W1X2	Pyridoxal kinase	ISS	11910005	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P00012	Cadherin signaling pathway	P00471	Cadherin	DROME|FlyBase=FBgn0261574|UniProtKB=Q9VW71	Fat-like cadherin-related tumor suppressor homolog	ISS	8120095	PubMed	PTHR24026:SF71	FAT-LIKE CADHERIN-RELATED TUMOR SUPPRESSOR HOMOLOG
P00052	TGF-beta signaling pathway	P01286	TGFbeta	HUMAN|HGNC=24029|UniProtKB=P58166	Inhibin beta E chain	TAS	9759503	PubMed	PTHR11848:SF6	INHIBIN BETA E CHAIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00046	Oxidative stress response	P01135	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	MACMU|Ensembl=ENSMMUG00000023317|UniProtKB=F6Y514	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00018	EGF receptor signaling pathway	P00548	RKIP	DICDI|dictyBase=DDB_G0275583|UniProtKB=Q86H88	Uncharacterized protein	ISS			PTHR11362:SF72	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	RAT|RGD=2364|UniProtKB=P11442	Clathrin heavy chain 1	IDA	9388255	PubMed	PTHR10292:SF7	CLATHRIN HEAVY CHAIN 1
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	14765990	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00009	Axon guidance mediated by netrin	P00364	cdc42	DROME|FlyBase=FBgn0010341|UniProtKB=P40793	Cdc42 homolog	ISS	9658176	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00052	TGF-beta signaling pathway	P01292	RSmads	MACMU|Ensembl=ENSMMUG00000018384|UniProtKB=F7GZL6	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00021	FGF signaling pathway	P00639	Shc	MOUSE|MGI=MGI=98296|UniProtKB=P98083	SHC-transforming protein 1	IGI	10982827	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00047	PDGF signaling pathway	P01173	STAT	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	12191995	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	MOUSE|MGI=MGI=99460|UniProtKB=Q61982	Neurogenic locus notch homolog protein 3	IDA	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	22533439	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00029	Huntington disease	P00807	Actin	DANRE|ZFIN=ZDB-GENE-040625-35|UniProtKB=Q6IQL9	Novel actin protein	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEEL|WormBase=WBGene00004033|UniProtKB=P90980	Protein kinase C-like 2	ISS	2837282	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	RAT|RGD=1311441|UniProtKB=A0A0G2K3B7	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	7937853	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	HUMAN|HGNC=5292|UniProtKB=P30939	5-hydroxytryptamine receptor 1F	ISS	12181435	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	MYCTU|EnsemblGenome=Rv0570|UniProtKB=P9WH77	Vitamin B12-dependent ribonucleoside-diphosphate reductase	ISS			PTHR43371:SF1	SUBFAMILY NOT NAMED
P06664	Gonadotropin-releasing hormone receptor pathway	P06808	SNURF	MOUSE|MGI=MGI=98347|UniProtKB=P63163	Small nuclear ribonucleoprotein-associated protein N	RCA			PTHR10701:SF1	SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN N
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00006	Apoptosis signaling pathway	P00294	RAIDD	HUMAN|HGNC=2340|UniProtKB=P78560	Death domain-containing protein CRADD	ISS			PTHR15034:SF5	DEATH DOMAIN-CONTAINING PROTEIN CRADD
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00053	T cell activation	P01305	Calmodulin	RAT|RGD=2257|UniProtKB=P62161	Calmodulin	ISS	7514101	PubMed	PTHR23050:SF311	CALMODULIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	HUMAN|HGNC=19663|UniProtKB=Q9UBI6	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P06959	CCKR signaling map	P07095	PKCalpha	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	RCA	12058027	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P06587	Nicotine pharmacodynamics pathway	P06590	GNG	TAKRU|Ensembl=ENSTRUG00000007253|UniProtKB=H2SZQ1	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00019	Endothelin signaling pathway	P00567	PKG	MOUSE|MGI=MGI=108174|UniProtKB=P0C605	cGMP-dependent protein kinase 1	IGI	14568994	PubMed	PTHR24353:SF68	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00048	PI3 kinase pathway	P01188	Gbetagamma	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00525	N-WASP	BOVIN|Ensembl=ENSBTAG00000004643|UniProtKB=Q95107	Neural Wiskott-Aldrich syndrome protein	ISS	12932731	PubMed	PTHR23202:SF39	NEURAL WISKOTT-ALDRICH SYNDROME PROTEIN
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	ORNAN|Ensembl=ENSOANG00000000999|UniProtKB=F6WN02	Actin-related protein 2/3 complex subunit 5	ISS	9230079	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CANLF|Ensembl=ENSCAFG00000018634|UniProtKB=E2RFV2	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF253	TUBULIN BETA-4A CHAIN
P00055	Transcription regulation by bZIP transcription factor	P01392	TFIIH complex	MOUSE|MGI=MGI=1277143|UniProtKB=Q8VD76	General transcription factor IIH subunit 3	ISS			PTHR12831:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	IDA	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00006	Apoptosis signaling pathway	P00310	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01194	S6K	HUMAN|HGNC=10437|UniProtKB=Q9UBS0	Ribosomal protein S6 kinase beta-2	ISS	15116068	PubMed	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	DANRE|ZFIN=ZDB-GENE-991119-4|UniProtKB=Q9W6T7	Presenilin-1	TAS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	CANLF|Gene=PSEN1|UniProtKB=Q6RH31	Presenilin-1	ISS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	TAS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	BOVIN|Ensembl=ENSBTAG00000004322|UniProtKB=O77628	Proto-oncogene c-Fos	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00018	EGF receptor signaling pathway	P00543	ERK1-2	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P05918	p38 MAPK pathway	P06031	p38alpha	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	RCA	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MONDO|Ensembl=ENSMODG00000008382|UniProtKB=F7CDR6	Uncharacterized protein (Fragment)	ISS	12093103	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	PANTR|Ensembl=ENSPTRG00000003128|UniProtKB=H2Q2V4	Uncharacterized protein	ISS	11248120	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00029	Huntington disease	P00790	beta-Tubulin	GIAIC|EnsemblGenome=GL50803_101291|UniProtKB=A8BEI6	Beta tubulin	TAS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	11847220	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00013	Cell cycle	P00480	Proteasome	DANRE|ZFIN=ZDB-GENE-030131-984|UniProtKB=F1QGH9	26S proteasome non-ATPase regulatory subunit 11B	ISS	97227943	PubMed	PTHR10678:SF4	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11B
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	PANTR|Ensembl=ENSPTRG00000017238|UniProtKB=H2QRH7	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=12774|UniProtKB=P04628	Proto-oncogene Wnt-1	IDA	14644163	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00021	FGF signaling pathway	P00634	MEKK1-5	MOUSE|MGI=MGI=1346874|UniProtKB=Q61084	Mitogen-activated protein kinase kinase kinase 3	ISS	9006902	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00017	DNA replication	P00527	Histones	TAKRU|Ensembl=ENSTRUG00000012002|UniProtKB=H2U0B9	Histone H3	ISS	20448842	PubMed	PTHR11426:SF184	HISTONE H3.1T
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	THAPS|Gene=Thaps8069|UniProtKB=B8C8B4	Tubulin beta	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00019	Endothelin signaling pathway	P00589	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	NAS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	IGI	3755548	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00018	EGF receptor signaling pathway	P00561	STAT	MONDO|Ensembl=ENSMODG00000014816|UniProtKB=F7CHH2	Signal transducer and activator of transcription	ISS	8732682	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00029	Huntington disease	P00796	Kainate receptor	RAT|RGD=2735|UniProtKB=Q63273	Glutamate receptor ionotropic, kainate 5	IDA	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04393	Ras Pathway	P04570	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P06210	Activin beta signaling pathway	P06235	SARA	DROME|FlyBase=FBgn0026369|UniProtKB=Q7K9H6	FI05490p	IEA	http://flybase.org/reports/FBgn0026369.html	Website	PTHR22835:SF299	FI05490P
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000012922|UniProtKB=H2QJF2	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	14744428	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	TAS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00029	Huntington disease	P00805	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	XENTR|Xenbase=XB-GENE-1004371|UniProtKB=F6R882	Uncharacterized protein	ISS	12374786	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00010	B cell activation	P00367	NFAT	CANLF|Ensembl=ENSCAFG00000011625|UniProtKB=F1PDD9	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00005	Angiogenesis	P00181	SHP2	CHICK|Ensembl=ENSGALG00000004821|UniProtKB=Q90687	Tyrosine-protein phosphatase non-receptor type 11	ISS	14525967	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00010	B cell activation	P00371	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	ARATH|TAIR=AT1G13890|UniProtKB=Q9LMG8	Putative SNAP25 homologous protein SNAP30	ISS			PTHR19305:SF7	SNAP25 HOMOLOGOUS PROTEIN SNAP30-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	ANOGA|EnsemblGenome=AGAP001506|UniProtKB=Q7PXP3	AGAP001506-PA	IC			PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	DANRE|ZFIN=ZDB-GENE-010705-1|UniProtKB=Q90Z40	Guanine nucleotide-binding protein subunit gamma	IDA	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	BRAFL|Gene=BRAFLDRAFT_220697|UniProtKB=C3ZSF0	Putative uncharacterized protein	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-486685|UniProtKB=F6VT32	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00005	Angiogenesis	P00210	eNOS	BOVIN|Gene=NOS3|UniProtKB=P29473	Nitric oxide synthase, endothelial	ISS	10435050	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00036	Interleukin signaling pathway	P00964	p90RSK	BOVIN|Ensembl=ENSBTAG00000017639|UniProtKB=F1MZW8	Ribosomal protein S6 kinase	ISS	10480933	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00048	PI3 kinase pathway	P01194	S6K	MACMU|Ensembl=ENSMMUG00000019305|UniProtKB=F6S3T8	Ribosomal protein S6 kinase	ISS	11861821	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00005	Angiogenesis	P00223	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	G04714	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00018	EGF receptor signaling pathway	P00560	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	G01511	SPRY	MACMU|Ensembl=ENSMMUG00000014175|UniProtKB=F7ALK4	Uncharacterized protein	ISS	22024232	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	TAS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00006	Apoptosis signaling pathway	P00269	MAPK	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF330	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04572	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02771	Pyrimidine Metabolism	P03129	Aminotransferase	YEAST|SGD=S000003251|UniProtKB=P17649	4-aminobutyrate aminotransferase	ISS	2190186	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	DANRE|ZFIN=ZDB-GENE-991119-4|UniProtKB=Q9W6T7	Presenilin-1	IDA	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P04397	p53 pathway by glucose deprivation	P04641	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00470	F-actin	MOUSE|MGI=MGI=2444552|UniProtKB=Q8BFZ3	Beta-actin-like protein 2	IC	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IDA	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MACMU|Ensembl=ENSMMUG00000009679|UniProtKB=F6YBQ8	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=1309999|UniProtKB=Q922R0	cAMP-dependent protein kinase catalytic subunit PRKX	IC	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05918	p38 MAPK pathway	P06025	SRF	PANTR|Ensembl=ENSPTRG00000018189|UniProtKB=H2QT21	Uncharacterized protein	ISS	15326221	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00010	B cell activation	P00391	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P06664	Gonadotropin-releasing hormone receptor pathway	P06723	Inhba	MOUSE|MGI=MGI=96570|UniProtKB=Q04998	Inhibin beta A chain	RCA			PTHR11848:SF133	INHIBIN BETA A CHAIN
P00010	B cell activation	P00379	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	BOVIN|Ensembl=ENSBTAG00000019210|UniProtKB=F1MJV4	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CANLF|Gene=GRIN1|UniProtKB=Q5R1P0	Glutamate receptor ionotropic, NMDA 1	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	CAEBR|Gene=CBG06092|UniProtKB=A8X0X5	Protein CBR-LET-60	ISS	22022015	PubMed	PTHR24070:SF385	GTPASE HRAS
P00060	Ubiquitin proteasome pathway	P01494	19S proteasome	MONDO|Ensembl=ENSMODG00000013717|UniProtKB=F6Y9A7	Uncharacterized protein	ISS			PTHR23073:SF8	26S PROTEASE REGULATORY SUBUNIT 6B
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MOUSE|MGI=MGI=87909|UniProtKB=P62737	Actin, aortic smooth muscle	IDA	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00034	Integrin signalling pathway	P00920	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	IDA	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	ORNAN|Ensembl=ENSOANG00000004342|UniProtKB=F6S3B9	Uncharacterized protein	ISS			PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P00006	Apoptosis signaling pathway	P00274	JNK	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	ISS	10514528	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00570	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00566	ERK	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	IGI	20032362	PubMed	PTHR24055:SF330	SUBFAMILY NOT NAMED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	IC	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	BOVIN|Ensembl=ENSBTAG00000047719|UniProtKB=Q95136	D(1A) dopamine receptor	ISS	11248120	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	MONDO|Ensembl=ENSMODG00000007323|UniProtKB=F7EFD0	Uncharacterized protein	ISS	10476970	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P05915	Opioid proenkephalin pathway	P05994	G-protein	TAKRU|Ensembl=ENSTRUG00000007253|UniProtKB=H2SZQ1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00019	Endothelin signaling pathway	P00591	PLCbeta	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	DROME|FlyBase=FBgn0019947|UniProtKB=O02194	Presenilin homolog	TAS	12369105	PubMed	PTHR10202:SF13	PRESENILIN-2
P04393	Ras Pathway	P04569	Cdc42	DROME|FlyBase=FBgn0010341|UniProtKB=P40793	Cdc42 homolog	ISS	9658176	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IGI	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02730	Asparagine and aspartate biosynthesis	P02853	Asparagine synthetase	SCHPO|PomBase=SPBC119.10|UniProtKB=P78753	Probable asparagine synthetase [glutamine-hydrolyzing]	ISS			PTHR11772:SF2	ASPARAGINE SYNTHETASE
P00006	Apoptosis signaling pathway	P00302	ATF	CANLF|Ensembl=ENSCAFG00000012339|UniProtKB=E2RTH8	Uncharacterized protein	ISS	11390664	PubMed	PTHR23351:SF23	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-3
P06664	Gonadotropin-releasing hormone receptor pathway	P06794	MAP2K1/2	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	RCA	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	PANTR|Ensembl=ENSPTRG00000004892|UniProtKB=H2Q5U3	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P06587	Nicotine pharmacodynamics pathway	P06594	CHRNA4	MACMU|Ensembl=ENSMMUG00000015916|UniProtKB=F7AT89	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF401	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4
P00029	Huntington disease	P00797	p53	HUMAN|HGNC=11998|UniProtKB=P04637	Cellular tumor antigen p53	TAS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	ORNAN|Ensembl=ENSOANG00000006119|UniProtKB=F6WTY3	Uncharacterized protein	ISS	2433589	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IDA	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05916	Opioid prodynorphin pathway	P06002	G-protein	ORNAN|Ensembl=ENSOANG00000003489|UniProtKB=F7FSE3	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00545	JNK1-3	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CHICK|Ensembl=ENSGALG00000005801|UniProtKB=P09482	Neuronal acetylcholine receptor subunit alpha-4	IC	85270494	PubMed	PTHR18945:SF401	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4
P00045	Notch signaling pathway	P01111	LNXp80	RAT|RGD=1308159|UniProtKB=B6RHI6	Ligand of numb-protein X 1	ISS	9535908	PubMed	PTHR19964:SF14	E3 UBIQUITIN-PROTEIN LIGASE LNX
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	RAT|RGD=1304965|UniProtKB=A0A0G2K6E0	Protein Rhoc	ISS	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=109355|UniProtKB=O35526	Syntaxin-1A	ISS	1321498	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00018	EGF receptor signaling pathway	P00561	STAT	RAT|RGD=3772|UniProtKB=P52631	Signal transducer and activator of transcription 3	IGI	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	DROME|FlyBase=FBgn0024846|UniProtKB=O61443	Mitogen-activated protein kinase 14B	ISS	10514528	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00029	Huntington disease	P00780	Microtubule	IXOSC|EnsemblGenome=ISCW021482|UniProtKB=B7Q717	Beta-tubulin, putative (Fragment)	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00559	MEK1-2	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P02746	Heme biosynthesis	P02974	Uroporphyrinogen-III synthase	DROME|FlyBase=FBgn0030066|UniProtKB=Q9W3B3	CG1885, isoform A	ISS			PTHR12390:SF0	UROPORPHYRINOGEN-III SYNTHASE
P02752	Mannose metabolism	P03018	Mannose 1-P guanylyl transferase	AQUAE|EnsemblGenome=aq_718|UniProtKB=O66933	Mannose-1-phosphate guanyltransferase	IEA	9537320	PubMed	PTHR22572:SF124	SUBFAMILY NOT NAMED
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00020	FAS signaling pathway	P00615	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00056	VEGF signaling pathway	P01421	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	RCA			PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00047	PDGF signaling pathway	P01148	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	4504111	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00037	Ionotropic glutamate receptor pathway	P01026	KA	CHICK|Ensembl=ENSGALG00000015434|UniProtKB=F1NU20	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00059	p53 pathway	P01486	Akt	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	TAS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06959	CCKR signaling map	P07048	MEF2D	HUMAN|HGNC=6997|UniProtKB=Q14814	Myocyte-specific enhancer factor 2D	RCA		PubMed	PTHR11945:SF23	MYOCYTE-SPECIFIC ENHANCER FACTOR 2D
P00017	DNA replication	P00527	Histones	IXOSC|EnsemblGenome=ISCW002300|UniProtKB=B7P7T4	Histone H3	ISS	20448842	PubMed	PTHR11426:SF179	HISTONE H3.3
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00011	Blood coagulation	P00426	PC	RAT|RGD=3411|UniProtKB=P31394	Vitamin K-dependent protein C	ISS	6981412	gi	PTHR24278:SF0	VITAMIN K-DEPENDENT PROTEIN C
P00029	Huntington disease	P00805	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00990	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	XENTR|GeneID=394982|UniProtKB=P20399	Actin, alpha cardiac muscle 2	ISS	10974003	PubMed	PTHR11937:SF263	ACTIN
P00029	Huntington disease	P00790	beta-Tubulin	PRIPA|Gene=PPA21756|UniProtKB=H3FHK9	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF255	TUBA7L PROTEIN
P00018	EGF receptor signaling pathway	P00564	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=1759|UniProtKB=P19022	Cadherin-2	ISS	13678586	PubMed	PTHR24027:SF79	CADHERIN-2
P00057	Wnt signaling pathway	P01457	GBeta	PHYIT|EnsemblGenome=PITG_06376|UniProtKB=D0N4Q3	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta, putative	IDA	12081467	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	88318957	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	MONDO|Ensembl=ENSMODG00000016960|UniProtKB=F6V5G0	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	MACMU|Ensembl=ENSMMUG00000002658|UniProtKB=F7CB14	Uncharacterized protein	ISS	11248120	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P04393	Ras Pathway	P04542	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	P04626	GADD45	CANLF|Ensembl=ENSCAFG00000002174|UniProtKB=E2RK27	Uncharacterized protein	ISS	10097101	PubMed	PTHR10411:SF4	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 GAMMA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000001384|UniProtKB=F7GL73	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04393	Ras Pathway	P04552	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00048	PI3 kinase pathway	P01192	p110	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01150	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00996	STAT	MOUSE|MGI=MGI=103038|UniProtKB=P42227	Signal transducer and activator of transcription 3	IC	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000008826|UniProtKB=F6XUU0	Uncharacterized protein	ISS			PTHR11937:SF240	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04451	CRHR1	MOUSE|MGI=MGI=88498|UniProtKB=P35347	Corticotropin-releasing factor receptor 1	ISS	11145609	PubMed	PTHR12011:SF175	CORTICOTROPIN-RELEASING FACTOR RECEPTOR 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00012	Cadherin signaling pathway	P00474	Wnt	BOVIN|Ensembl=ENSBTAG00000015364|UniProtKB=E1BEN9	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	PSEAE|EnsemblGenome=PA0350|UniProtKB=Q9I6E3	Dihydrofolate reductase	ISS			PTHR22778:SF16	DIHYDROFOLATE REDUCTASE
P00055	Transcription regulation by bZIP transcription factor	P01390	TFIIA complex	MACMU|Ensembl=ENSMMUG00000022122|UniProtKB=F7H5J8	Transcription initiation factor IIA subunit 1 isoform 1	ISS	600519	OMIM	PTHR12694:SF7	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	BOVIN|Ensembl=ENSBTAG00000012687|UniProtKB=F1MV64	Tyrosine-protein kinase receptor	ISS	249616	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8717|UniProtKB=Q9Y5F7	Protocadherin gamma-C4	IDA	8120095	PubMed	PTHR24028:SF137	PROTOCADHERIN GAMMA-C4
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	MACMU|Ensembl=ENSMMUG00000013047|UniProtKB=F7H808	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	HALSA|EnsemblGenome=VNG_2093G|UniProtKB=Q9HNI2	Glutamine synthetase	ISS			PTHR43785:SF1	TYPE-1 GLUTAMINE SYNTHETASE 2
P00048	PI3 kinase pathway	P01177	P110ACT	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DROME|FlyBase=FBgn0000489|UniProtKB=P16912	Protein kinase DC2	IC	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	STRCO|Gene=CAD30959|UniProtKB=Q9ADJ9	Putative deaminase	ISS			PTHR44192:SF2	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00564	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	IC	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00052	TGF-beta signaling pathway	P01284	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000040329|UniProtKB=F1MMU1	Uncharacterized protein	ISS	11701344	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00048	PI3 kinase pathway	P01179	PKB	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00005	Angiogenesis	P00223	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	PRIPA|Gene=PPA25500|UniProtKB=H3FT78	Uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	CANLF|Ensembl=ENSCAFG00000000828|UniProtKB=F6UWI0	Ribosomal protein S6 kinase	ISS	15526037	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00021	FGF signaling pathway	P00629	PP2A	CHICK|Ensembl=ENSGALG00000015531|UniProtKB=E1C2X1	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B	ISS	12191994	PubMed	PTHR11871:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B GAMMA ISOFORM
P00025	Hedgehog signaling pathway	P00682	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00477	GSK3beta	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00019	Endothelin signaling pathway	P00570	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P05915	Opioid proenkephalin pathway	P05994	G-protein	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	IC	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01063	CAT	PANTR|Ensembl=ENSPTRG00000002489|UniProtKB=H2RAF8	Uncharacterized protein	ISS	97225904	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P00012	Cadherin signaling pathway	P00470	F-actin	ORYSJ|EnsemblGenome=OS05G0106600|UniProtKB=Q65XH8	Os05g0106600 protein	IC	11889126	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TRYB2|Gene=Tb09.211.0620|UniProtKB=Q38E94	Actin A	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	TAS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000012922|UniProtKB=H2QJF2	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00034	Integrin signalling pathway	P00922	Collagen	MOUSE|MGI=MGI=88446|UniProtKB=Q61245	Collagen alpha-1(XI) chain	IDA	10778855	PubMed	PTHR24023:SF42	COLLAGEN ALPHA-1 XI  CHAIN
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	MOUSE|MGI=MGI=109524|UniProtKB=Q9QX29	Short transient receptor potential channel 5	IDA	11055438	PubMed	PTHR10117:SF24	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 5
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	CANLF|Ensembl=ENSCAFG00000010787|UniProtKB=E2R3W6	Uncharacterized protein	ISS	11248120	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00029	Huntington disease	P00775	Rac	MACMU|Ensembl=ENSMMUG00000003957|UniProtKB=F6ZFI9	Rho-related GTP-binding protein RhoG	ISS	12932731	PubMed	PTHR24072:SF158	RHO-RELATED GTP-BINDING PROTEIN RHOG
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MONDO|Ensembl=ENSMODG00000001389|UniProtKB=F7BD45	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF657	MYOSIN-4
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01413	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00005	Angiogenesis	P00221	JNK1	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	XENTR|Xenbase=XB-GENE-956713|UniProtKB=Q5XGD8	Guanine nucleotide binding protein, beta 3	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00012	Cadherin signaling pathway	P00470	F-actin	CANLF|Ensembl=ENSCAFG00000008756|UniProtKB=F2Z4N8	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IGI	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P06216	SCW signaling pathway	P06321	LACK	DROME|FlyBase=FBgn0029006|UniProtKB=Q9V853	E3 ubiquitin-protein ligase Smurf1	IEA	11252892	PubMed	PTHR11254:SF395	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P00021	FGF signaling pathway	P00624	14-3-3	RAT|RGD=3978|UniProtKB=P68511	14-3-3 protein eta	ISS	6756037	gi	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00274	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	ISS	10851062	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00056	VEGF signaling pathway	P01408	Akt/PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	1170702	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	DANRE|ZFIN=ZDB-GENE-030131-8783|UniProtKB=Q52WY2	Ras-like protein Cdc42a	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00037	Ionotropic glutamate receptor pathway	P01026	KA	PANTR|Ensembl=ENSPTRG00000000543|UniProtKB=H2PYN8	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02777	Succinate to proprionate conversion	P03161	Methylmalonyl-CoA mutase	DEIRA|EnsemblGenome=DR_2032|UniProtKB=Q9RSU1	Methylmalonyl-CoA mutase	ISS			PTHR23408:SF19	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01177	P110ACT	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00055	Transcription regulation by bZIP transcription factor	P01390	TFIIA complex	MACMU|Ensembl=ENSMMUG00000018428|UniProtKB=F7HH39	Transcription initiation factor IIA subunit 2	ISS			PTHR10966:SF0	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	DICDI|dictyBase=DDB_G0283537|UniProtKB=P32254	Ras-like protein rasS	ISS	8290260	PubMed	PTHR24070:SF380	RAS-LIKE PROTEIN RASS
P00056	VEGF signaling pathway	P01408	Akt/PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	DANRE|ZFIN=ZDB-GENE-000330-9|UniProtKB=Q90ZE4	Presenilin-2	IDA	12424519	PubMed	PTHR10202:SF13	PRESENILIN-2
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	MACMU|Ensembl=ENSMMUG00000019351|UniProtKB=Q2YEG0	C-X-C chemokine receptor type 1	ISS	6753456	gi	PTHR10489:SF916	C-X-C CHEMOKINE RECEPTOR TYPE 1
P02728	Arginine biosynthesis	P02842	N-acetylornithine aminotransferase	ECOLI|EcoGene=EG13999|UniProtKB=P77581	Succinylornithine transaminase	ISS			PTHR11986:SF113	SUCCINYLORNITHINE TRANSAMINASE
P00036	Interleukin signaling pathway	P00978	Jak	BOVIN|Ensembl=ENSBTAG00000020904|UniProtKB=E1BEL4	Tyrosine-protein kinase	ISS	15179321	PubMed	PTHR24418:SF233	TYROSINE-PROTEIN KINASE JAK3
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	MOUSE|MGI=MGI=2388633|UniProtKB=Q68FD5	Clathrin heavy chain 1	ISS	9388255	PubMed	PTHR10292:SF7	CLATHRIN HEAVY CHAIN 1
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00012	Cadherin signaling pathway	P00470	F-actin	TAKRU|Ensembl=ENSTRUG00000007989|UniProtKB=P68140	Actin, alpha skeletal muscle A	IC	11889139	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P06664	Gonadotropin-releasing hormone receptor pathway	P06847	JNK1/2	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	RCA	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	XENTR|Xenbase=XB-GENE-975313|UniProtKB=F7CSQ4	Uncharacterized protein	ISS	96032356	PubMed	PTHR11958:SF24	EXCITATORY AMINO ACID TRANSPORTER 1
P00050	Plasminogen activating cascade	P01254	pro-MMP-13	HUMAN|HGNC=7159|UniProtKB=P45452	Collagenase 3	IDA	12834808	PubMed	PTHR10201:SF165	COLLAGENASE 3
P04393	Ras Pathway	P04578	Rho	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	ISS	15668138	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02738	De novo purine biosynthesis	P02909	GDP reductase	STRCO|Gene=CAB94611|UniProtKB=Q9K496	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01167	Ets	PANTR|Ensembl=ENSPTRG00000028999|UniProtKB=H2R3U4	Ets2 repressor factor	ISS	15298723	PubMed	PTHR11849:SF31	ETS DOMAIN-CONTAINING TRANSCRIPTION FACTOR ERF
P00018	EGF receptor signaling pathway	P00543	ERK1-2	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01208	Hsp70	DANRE|ZFIN=ZDB-GENE-990415-92|UniProtKB=Q90473	Heat shock cognate 71 kDa protein	IDA	12150907	PubMed	PTHR19375:SF239	HEAT SHOCK COGNATE 71 KDA PROTEIN
P00029	Huntington disease	P00778	NMDA receptor	BOVIN|Ensembl=ENSBTAG00000000219|UniProtKB=F1MCL3	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00037	Ionotropic glutamate receptor pathway	P01026	KA	PANTR|Ensembl=ENSPTRG00000013825|UniProtKB=H2RAK4	Uncharacterized protein	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00048	PI3 kinase pathway	P01202	p85	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00019	Endothelin signaling pathway	P00591	PLCbeta	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00045	Notch signaling pathway	P01119	NIct	MACMU|Ensembl=ENSMMUG00000017022|UniProtKB=F7HQZ9	Uncharacterized protein	ISS	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IGI	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00010	B cell activation	P00384	p38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IDA	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00006	Apoptosis signaling pathway	P00274	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P02738	De novo purine biosynthesis	P02909	GDP reductase	AQUAE|EnsemblGenome=aq_1505|UniProtKB=O67475	Ribonucleoside-diphosphate reductase subunit beta	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00029	Huntington disease	P00805	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01164	PDK1/2	YEAST|SGD=S000005460|UniProtKB=Q12236	Serine/threonine-protein kinase PKH2	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000000931|UniProtKB=H2PZC4	Protein kinase N2	ISS	10644715	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	XENTR|Xenbase=XB-GENE-868117|UniProtKB=Q28C95	Amino-terminal enhancer of split	ISS	9783586	PubMed	PTHR10814:SF4	AMINO-TERMINAL ENHANCER OF SPLIT-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CHICK|Ensembl=ENSGALG00000008898|UniProtKB=F1P2J9	Uncharacterized protein	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00015	Circadian clock system	G01501	cry	CANLF|Ensembl=ENSCAFG00000009379|UniProtKB=F1PNC9	Uncharacterized protein	ISS	11533252	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000035697|UniProtKB=Q28024	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00049	Parkinson disease	P01208	Hsp70	DANRE|ZFIN=ZDB-GENE-040426-1221|UniProtKB=Q6PGX4	Heat shock cognate 71 kDa protein	IDA	12150907	PubMed	PTHR19375:SF310	HEAT SHOCK COGNATE 71 KDA PROTEIN
P04393	Ras Pathway	P04569	Cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00034	Integrin signalling pathway	P00907	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04395	Vasopressin synthesis	P04597	Signal Peptide	HUMAN|HGNC=8528|UniProtKB=P01178	Oxytocin-neurophysin 1	ISS	1706187	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00029	Huntington disease	P00778	NMDA receptor	MOUSE|MGI=MGI=95819|UniProtKB=P35438	Glutamate receptor ionotropic, NMDA 1	IDA	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00005	Angiogenesis	P00215	Nck	PANTR|Ensembl=ENSPTRG00000015434|UniProtKB=G2HHN0	Cytoplasmic protein NCK1	ISS	12874226	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P02734	Chorismate biosynthesis	P02868	Chorismate synthase	BACTN|EnsemblGenome=BT_2084|UniProtKB=Q8A602	Chorismate synthase	ISS			PTHR21085:SF0	CHORISMATE SYNTHASE
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	MOUSE|MGI=MGI=1351341|UniProtKB=Q68EF4	Metabotropic glutamate receptor 4	IC	12351712	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00046	Oxidative stress response	P01128	MEF-2	DANRE|ZFIN=ZDB-GENE-980526-253|UniProtKB=Q6NSN7	Mef2ca protein	ISS			PTHR11945:SF356	MEF2CA PROTEIN
P00057	Wnt signaling pathway	P01443	Phospholipase C	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IDA	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00760	Gtalpha	XENTR|Xenbase=XB-GENE-1003264|UniProtKB=A4IHG6	LOC100124843 protein	ISS	6264430	PubMed	PTHR10218:SF67	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-1
P05918	p38 MAPK pathway	P06021	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12912997	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00021	FGF signaling pathway	P00623	FGF	HUMAN|HGNC=3666|UniProtKB=O15520	Fibroblast growth factor 10	ISS	20411101	PubMed	PTHR11486:SF21	FIBROBLAST GROWTH FACTOR 10
P02785	Valine biosynthesis	P03215	Branched chain amino acid aminotransferase	YEAST|SGD=S000003909|UniProtKB=P47176	Branched-chain-amino-acid aminotransferase, cytosolic	ISS			PTHR11825:SF44	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P00054	Toll receptor signaling pathway	P01380	TLR1,2,6	PANTR|Gene=TLR2|UniProtKB=B3Y613	Toll-like receptor 2	ISS			PTHR24365:SF17	TOLL-LIKE RECEPTOR 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ORNAN|Ensembl=ENSOANG00000007581|UniProtKB=F6QWB7	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	MONDO|Ensembl=ENSMODG00000018237|UniProtKB=F6PG65	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	IC	10514528	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P02738	De novo purine biosynthesis	P02907	dADP kinase	PANTR|Ensembl=ENSPTRG00000009415|UniProtKB=H2QDG2	Nucleoside diphosphate kinase	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P02728	Arginine biosynthesis	P02842	N-acetylornithine aminotransferase	SYNY3|EnsemblGenome=BAA17159|UniProtKB=P73133	Acetylornithine aminotransferase	ISS	10074354	PubMed	PTHR11986:SF79	ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	HALSA|EnsemblGenome=VNG_0502G|UniProtKB=Q9HRX4	Aspartate aminotransferase	ISS			PTHR11751:SF430	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	BOVIN|Ensembl=ENSBTAG00000004368|UniProtKB=F1MSU2	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	11832947	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	HUMAN|HGNC=4581|UniProtKB=Q13003	Glutamate receptor ionotropic, kainate 3	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01168	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00801	Fos protein	RAT|RGD=2626|UniProtKB=P12841	Proto-oncogene c-Fos	TAS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00056	VEGF signaling pathway	P01413	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00167	CD44 transmembrane fragment	HUMAN|HGNC=1681|UniProtKB=P16070	CD44 antigen	IDA	12223485	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P02772	Pyruvate metabolism	P03132	Pyruvate Kinase	RAT|RGD=3336|UniProtKB=P12928	Pyruvate kinase PKLR	RCA			PTHR11817:SF31	PYRUVATE KINASE PKLR
P02783	Tryptophan biosynthesis	P03209	Anthranilate phosphoribosyl transferase	BACSU|EnsemblGenome=BSU22670|UniProtKB=P03947	Anthranilate phosphoribosyltransferase	ISS			PTHR43285:SF2	ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE
P00047	PDGF signaling pathway	P01165	SRF	BOVIN|Ensembl=ENSBTAG00000012777|UniProtKB=E1BJP4	Uncharacterized protein	ISS	15647354	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00005	Angiogenesis	P00223	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P06211	BMP/activin signaling pathway-drosophila	P06245	R-Smad	DROME|FlyBase=FBgn0011648|UniProtKB=P42003	Protein mothers against dpp	RCA	12736218	PubMed	PTHR13703:SF40	PROTEIN MOTHERS AGAINST DPP
P00037	Ionotropic glutamate receptor pathway	P01020	NSF	DROME|FlyBase=FBgn0051495|UniProtKB=Q8ING5	RE10813p	ISS	11348590	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00057	Wnt signaling pathway	P01453	Ebi	CHICK|Ensembl=ENSGALG00000013837|UniProtKB=F1NLX1	Uncharacterized protein	ISS	11389839	PubMed	PTHR22846:SF40	F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN TBL1XR1
P00005	Angiogenesis	P00223	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	1170702	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	RAT|RGD=68942|UniProtKB=O54898	Voltage-dependent T-type calcium channel subunit alpha-1G	ISS	14526084	PubMed	PTHR10037:SF137	VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1G
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MOUSE|MGI=MGI=1338938|UniProtKB=P36895	Bone morphogenetic protein receptor type-1A	TAS	10683140	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01237	Complex I	DROME|FlyBase=FBgn0036706|UniProtKB=Q9VVF0	AT21479p	TAS	3100899	PubMed	PTHR10371:SF3	NADH DEHYDROGENASE  UBIQUINONE  FLAVOPROTEIN 2, MITOCHONDRIAL
P00018	EGF receptor signaling pathway	P00547	PP2A	MOUSE|MGI=MGI=1321159|UniProtKB=P63330	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_56698|UniProtKB=C3XYC3	Putative uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	RAT|RGD=1309504|UniProtKB=D3ZRN3	Protein Actbl2	ISS	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00013	Cell cycle	P00483	Cyclin E	MOUSE|MGI=MGI=88316|UniProtKB=Q61457	G1/S-specific cyclin-E1	ISS	6671698	gi	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	ISS	7925653	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	MONDO|Ensembl=ENSMODG00000015399|UniProtKB=F6T507	Uncharacterized protein	ISS	96032356	PubMed	PTHR11958:SF69	EXCITATORY AMINO ACID TRANSPORTER 3
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00059	p53 pathway	P04609	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00009	Axon guidance mediated by netrin	P00356	UNC-5	MOUSE|MGI=MGI=894682|UniProtKB=Q8K1S4	Netrin receptor UNC5A	ISS			PTHR12582:SF4	NETRIN RECEPTOR UNC5A
P05915	Opioid proenkephalin pathway	P05994	G-protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	8387895	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04374	5HT2 type receptor mediated signaling pathway	P04413	K+ channel	CHICK|Ensembl=ENSGALG00000016193|UniProtKB=E1BYI0	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P04373	5HT1 type receptor mediated signaling pathway	P04409	5HT transporter	PANTR|Ensembl=ENSPTRG00000008958|UniProtKB=H2QCL1	Transporter	ISS	7681602	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P00034	Integrin signalling pathway	P00910	Grb2	BOVIN|Ensembl=ENSBTAG00000003707|UniProtKB=A6QLK6	GRB2-related adapter protein	ISS	51702266	gi	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P02748	Isoleucine biosynthesis	P02996	Ketol-acid reductoisomerase	SCHPO|PomBase=SPBC56F2.12|UniProtKB=P78827	Probable ketol-acid reductoisomerase, mitochondrial	ISS			PTHR21371:SF13	KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL
P00057	Wnt signaling pathway	P01452	NFAT	RAT|RGD=1307690|UniProtKB=D4A0I8	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (Predicted), isoform CRA_b	ISS	12015605	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=2136742|UniProtKB=Q91XZ2	MCG141292	IDA	8120095	PubMed	PTHR24028:SF100	MCG141292-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	RAT|RGD=70964|UniProtKB=Q62893	Anti-Muellerian hormone type-2 receptor	TAS	9759503	PubMed	PTHR23255:SF49	ANTI-MUELLERIAN HORMONE TYPE-2 RECEPTOR
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	IXOSC|EnsemblGenome=ISCW014549|UniProtKB=B7QGY5	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00046	Oxidative stress response	P01129	JNK1/2	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00006	Apoptosis signaling pathway	P00269	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02787	Vitamin B6 metabolism	P03227	Phosphoserine transaminase	ARATH|TAIR=AT4G35630|UniProtKB=Q96255	Phosphoserine aminotransferase 1, chloroplastic	ISS	15237069	gi	PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P04398	p53 pathway feedback loops 2	P04665	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00110	Ire-1 N-terminal fragment	MOUSE|MGI=MGI=1930134|UniProtKB=Q9EQY0	Serine/threonine-protein kinase/endoribonuclease IRE1	IDA	10619423	PubMed	PTHR13954:SF17	SERINE/THREONINE-PROTEIN KINASE/ENDORIBONUCLEASE IRE1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00048	PI3 kinase pathway	P01199	Galpha	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IC	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	ANOGA|EnsemblGenome=AGAP010958|UniProtKB=Q7PFI3	AGAP010958-PA	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	CANLF|Ensembl=ENSCAFG00000008977|UniProtKB=J9P7Q4	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF4	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=8155|UniProtKB=P41146	Nociceptin receptor	IDA	11259487	PubMed	PTHR24229:SF11	NOCICEPTIN RECEPTOR
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	LEIMA|EnsemblGenome=LmjF.04.1230|UniProtKB=Q9U1E8	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	MACMU|Ensembl=ENSMMUG00000010424|UniProtKB=F7CXM3	Short transient receptor potential channel 5	ISS	11055438	PubMed	PTHR10117:SF24	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 5
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04397	p53 pathway by glucose deprivation	P04641	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MOUSE|MGI=MGI=1931027|UniProtKB=Q9ER00	Syntaxin-12	ISS	14570579	PubMed	PTHR19957:SF88	SYNTAXIN-12
P00012	Cadherin signaling pathway	P00463	betacatenin	XENTR|Xenbase=XB-GENE-487200|UniProtKB=Q28GC2	Catenin (Cadherin associated protein), beta 1, 88kDa	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00010	B cell activation	P00375	Calmodulin	CANLF|Ensembl=ENSCAFG00000017516|UniProtKB=E2REK6	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF311	CALMODULIN
P04397	p53 pathway by glucose deprivation	P04641	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P06959	CCKR signaling map	P07188	RHOA-GTP	HUMAN|HGNC=667|UniProtKB=P61586	Transforming protein RhoA	RCA	15331357	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00007	Axon guidance mediated by semaphorins	P00336	Cdk5	MACMU|Ensembl=ENSMMUG00000020451|UniProtKB=F6VZU3	Uncharacterized protein	ISS	10604473	PubMed	PTHR24056:SF46	CYCLIN-DEPENDENT-LIKE KINASE 5
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=1951|UniProtKB=P08172	Muscarinic acetylcholine receptor M2	IDA	8100450	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	88248000	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=14674|UniProtKB=Q96QU1	Protocadherin-15	IDA	8120095	PubMed	PTHR24028:SF11	PROTOCADHERIN-15
P04393	Ras Pathway	P04567	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P05730	Endogenous cannabinoid signaling	P05751	Galpha	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P02738	De novo purine biosynthesis	P02909	GDP reductase	TRYB2|Gene=Tb11.v4.0005|UniProtKB=Q382Q2	Ribonucleoside-diphosphate reductase small chain	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	CANLF|Ensembl=ENSCAFG00000013547|UniProtKB=E2QVP7	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF126	FRIZZLED-5
P00010	B cell activation	P00388	PLC gamma2	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	IGI	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00018	EGF receptor signaling pathway	P00552	Ras	BOVIN|Ensembl=ENSBTAG00000020983|UniProtKB=Q2TBH2	Related RAS viral (R-ras) oncogene homolog	ISS	7997267	PubMed	PTHR24070:SF245	RAS-RELATED PROTEIN R-RAS
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00752	cGMP-gated ion channel	CANLF|Gene=CNGA1|UniProtKB=Q28279	cGMP-gated cation channel alpha-1	IDA	12432397	PubMed	PTHR10217:SF387	CYCLIC NUCLEOTIDE-GATED CHANNEL ROD PHOTORECEPTOR SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00982	p27KIP1	BOVIN|Ensembl=ENSBTAG00000018254|UniProtKB=A6QLS3	CDKN1B protein	ISS	12244303	PubMed	PTHR10265:SF9	CYCLIN-DEPENDENT KINASE INHIBITOR 1B
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	NAS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00006	Apoptosis signaling pathway	P00321	HSP70	HUMAN|HGNC=5238|UniProtKB=P11021	78 kDa glucose-regulated protein	IDA	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	PANTR|Ensembl=ENSPTRG00000014976|UniProtKB=H2R892	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00029	Huntington disease	G01535	PIG3	DICDI|dictyBase=DDB_G0271884|UniProtKB=Q869N7	Uncharacterized protein	TAS	12932731	PubMed	PTHR42975:SF1	QUINONE OXIDOREDUCTASE-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00036	Interleukin signaling pathway	P00996	STAT	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	14755057	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00037	Ionotropic glutamate receptor pathway	P01026	KA	RAT|RGD=2735|UniProtKB=Q63273	Glutamate receptor ionotropic, kainate 5	ISS	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12874273	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	129387	gi	PTHR10048:SF14	PI-3 KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	MACMU|Ensembl=ENSMMUG00000010184|UniProtKB=F6SR09	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00053	T cell activation	P01332	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	IC	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	BOVIN|Gene=SLC18A2|UniProtKB=Q27963	Synaptic vesicular amine transporter	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00049	Parkinson disease	P01211	ERK	ORYSJ|EnsemblGenome=OS02G0148100|UniProtKB=Q6Z437	Mitogen-activated protein kinase 3	IDA	6491800	gi	PTHR24055:SF216	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00638	PLCgamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00047	PDGF signaling pathway	P01142	p90RSK	CANLF|Ensembl=ENSCAFG00000013171|UniProtKB=E2RP04	Uncharacterized protein	ISS	2779569	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P05730	Endogenous cannabinoid signaling	P05751	Galpha	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05915	Opioid proenkephalin pathway	P05995	proenkephalin	MOUSE|MGI=MGI=104629|UniProtKB=P22005	Proenkephalin-A	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00019	Endothelin signaling pathway	P00591	PLCbeta	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00009	Axon guidance mediated by netrin	P00364	cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00053	T cell activation	P01311	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	3449797	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P04380	Cortocotropin releasing factor receptor signaling pathway	P04455	beta-endorphin	RAT|RGD=3366|UniProtKB=P01194	Pro-opiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P04393	Ras Pathway	P04567	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IDA	1171954	gi	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00048	PI3 kinase pathway	P01188	Gbetagamma	DROME|FlyBase=FBgn0001105|UniProtKB=P26308	Guanine nucleotide-binding protein subunit beta-1	IC	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01081	Ca2+ channel	RAT|RGD=2247|UniProtKB=P54290	Voltage-dependent calcium channel subunit alpha-2/delta-1	ISS	92228762	PubMed	PTHR10166:SF6	VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00036	Interleukin signaling pathway	P00981	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00057	Wnt signaling pathway	P01438	PP2A	DANRE|ZFIN=ZDB-GENE-040426-877|UniProtKB=F1Q6Z7	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=1261834|UniProtKB=O70283	Protein Wnt-2b	IDA	12549854	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	HUMAN|HGNC=2323|UniProtKB=P31327	Carbamoyl-phosphate synthase [ammonia], mitochondrial	ISS			PTHR11405:SF38	CARBAMOYL-PHOSPHATE SYNTHASE  AMMONIA , MITOCHONDRIAL
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00059	p53 pathway	G04694	p110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01223	UbcH8	ANOGA|EnsemblGenome=AGAP001056|UniProtKB=Q7QDD7	AGAP001056-PA	IDA			PTHR24068:SF116	AT26201P-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DROME|FlyBase=FBgn0001123|UniProtKB=P20354	G protein alpha s subunit	IC	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P02721	ATP synthesis	P02791	F1 alpha	CHICK|Ensembl=ENSGALG00000001756|UniProtKB=F1NGA2	ATP synthase subunit alpha	ISS	2527557	PubMed	PTHR43089:SF5	ATP SYNTHASE SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00108	ADAM10	MOUSE|MGI=MGI=109548|UniProtKB=O35598	Disintegrin and metalloproteinase domain-containing protein 10	IDA	12354787	PubMed	PTHR11905:SF4	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 10
P00053	T cell activation	P01312	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00015	Circadian clock system	G01501	cry	RAT|RGD=735083|UniProtKB=Q32Q86	Cryptochrome-1	ISS	10428031	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01438	PP2A	STRPU|EnsemblGenome=SPU_025182|UniProtKB=W4ZAK5	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P02723	Adenine and hypoxanthine salvage pathway	P02804	Hypoxanthine phosphoribosyl transferase	MACMU|Ensembl=ENSMMUG00000018728|UniProtKB=F6YAZ3	Uncharacterized protein	ISS			PTHR43340:SF5	PHOSPHORIBOSYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1
P00010	B cell activation	P00385	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF248	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04547	Ras	CAEBR|Gene=CBG06092|UniProtKB=A8X0X5	Protein CBR-LET-60	ISS	22022015	PubMed	PTHR24070:SF385	GTPASE HRAS
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	TAS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04393	Ras Pathway	P04570	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00038	JAK/STAT signaling pathway	P01027	STAT	PANTR|Ensembl=ENSPTRG00000009199|UniProtKB=H2QD19	Signal transducer and activator of transcription	ISS	14662325	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	BOVIN|Ensembl=ENSBTAG00000005714|UniProtKB=Q3ZC07	Actin, alpha cardiac muscle 1	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00004	Alzheimer disease-presenilin pathway	P00170	Aph-1	CAEEL|WormBase=WBGene00000147|UniProtKB=O45876	Gamma-secretase subunit aph-1	IDA	12110170	PubMed	PTHR12889:SF0	GAMMA-SECRETASE SUBUNIT APH-1
P02746	Heme biosynthesis	P02982	Protoheme IX farnesyl transferase	MACMU|Ensembl=ENSMMUG00000016157|UniProtKB=F7FTL6	Protoheme IX farnesyltransferase, mitochondrial	ISS			PTHR43448:SF2	PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL
P04393	Ras Pathway	P04567	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00059	p53 pathway	P04609	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	7937853	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00054	Toll receptor signaling pathway	P01368	MKK2	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PLAF7|EnsemblGenome=PF14_0124|UniProtKB=Q8ILW9	Actin-2	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00029	Huntington disease	P00780	Microtubule	LEIMA|EnsemblGenome=LmjF.21.1860|UniProtKB=Q4QBZ6	Beta tubulin	IDA	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8697|UniProtKB=Q9Y5H3	Protocadherin gamma-A10	IDA	8120095	PubMed	PTHR24028:SF110	PROTOCADHERIN GAMMA-A10
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02769	Purine metabolism	P03116	Xanthine Oxidase	MACMU|Ensembl=ENSMMUG00000000561|UniProtKB=F6Y3F0	Uncharacterized protein	ISS	8708081	PubMed	PTHR11908:SF80	XANTHINE DEHYDROGENASE/OXIDASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CANLF|Ensembl=ENSCAFG00000010298|UniProtKB=P11616	Adenosine receptor A1	ISS	11781138	PubMed	PTHR24246:SF1	ADENOSINE RECEPTOR A1
P00019	Endothelin signaling pathway	P00590	IP3 R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=1850|UniProtKB=Q9NYQ6	Cadherin EGF LAG seven-pass G-type receptor 1	IDA	8120095	PubMed	PTHR24026:SF36	CADHERIN EGF LAG SEVEN-PASS G-TYPE RECEPTOR 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00010	B cell activation	P00392	I kappa B	CANLF|Ensembl=ENSCAFG00000013418|UniProtKB=E2RML9	Uncharacterized protein	ISS	14665694	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	CHICK|Gene=PSEN2|UniProtKB=Q90X07	Presenilin-2	IDA	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00013	Cell cycle	P00480	Proteasome	CANLF|Ensembl=ENSCAFG00000012565|UniProtKB=F1PRW0	Uncharacterized protein	ISS	13645506	gi	PTHR10223:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02742	Tetrahydrofolate biosynthesis	P02951	GTP cyclohydrolase	DANRE|ZFIN=ZDB-GENE-001205-3|UniProtKB=Q6IQV5	GTP cyclohydrolase 2	ISS			PTHR11109:SF4	GTP CYCLOHYDROLASE 2
P06664	Gonadotropin-releasing hormone receptor pathway	P06847	JNK1/2	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	RCA	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00006	Apoptosis signaling pathway	P00290	Blk	MOUSE|MGI=MGI=1206591|UniProtKB=O70337	Bcl-2-interacting killer	IDA	11714762	PubMed	PTHR15018:SF1	BCL-2-INTERACTING KILLER
P00059	p53 pathway	P01486	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00221	JNK1	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_56687|UniProtKB=C3YC50	Putative uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00188	Ets	BOVIN|Ensembl=ENSBTAG00000002341|UniProtKB=A5PJG9	ETS1 protein	ISS	15298723	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00023	General transcription regulation	P00668	TFIIB	DANRE|ZFIN=ZDB-GENE-030131-6334|UniProtKB=F1R9S3	Uncharacterized protein	ISS	180660	OMIM	PTHR11618:SF4	TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT
P00012	Cadherin signaling pathway	P00470	F-actin	CHICK|Ensembl=ENSGALG00000009844|UniProtKB=P68034	Actin, alpha cardiac muscle 1	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	TAS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05913	Enkephalin release	P05972	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00030	Hypoxia response via HIF activation	P00824	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00006	Apoptosis signaling pathway	P00269	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00038	JAK/STAT signaling pathway	P01031	PIAS	CANLF|Ensembl=ENSCAFG00000017463|UniProtKB=F1PQ60	Uncharacterized protein	ISS	8682149	PubMed	PTHR10782:SF11	E3 SUMO-PROTEIN LIGASE PIAS1
P00050	Plasminogen activating cascade	P01263	pro-MMP-1	MACMU|Ensembl=ENSMMUG00000002037|UniProtKB=F6WYF2	Uncharacterized protein	ISS	3009463	PubMed	PTHR10201:SF151	INTERSTITIAL COLLAGENASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	PANTR|Ensembl=ENSPTRG00000006468|UniProtKB=H2Q8H8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21230:SF26	VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1B
P00048	PI3 kinase pathway	P01179	PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	CAEEL|WormBase=WBGene00009035|UniProtKB=Q19699	Glutamine-Fructose 6-phosphate AminoTransferase homolog	ISS			PTHR10937:SF0	GH12731P-RELATED
P00029	Huntington disease	P00801	Fos protein	MONDO|Ensembl=ENSMODG00000005927|UniProtKB=F6WX28	Uncharacterized protein	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00010	B cell activation	P00401	jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	ANOGA|EnsemblGenome=AGAP005911|UniProtKB=Q7Q6D4	AGAP005911-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00010	B cell activation	P00386	Calcineurin	HUMAN|HGNC=9315|UniProtKB=P16298	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	IDA	7532676	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00629	PP2A	MOUSE|MGI=MGI=1920180|UniProtKB=Q6ZWR4	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform	ISS	9125135	PubMed	PTHR11871:SF1	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B BETA ISOFORM
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04393	Ras Pathway	P04550	Ral	DANRE|ZFIN=ZDB-GENE-040801-267|UniProtKB=Q6DC92	Uncharacterized protein	ISS	7687439	PubMed	PTHR24070:SF199	RAS-RELATED PROTEIN RAL-B
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	BOVIN|Ensembl=ENSBTAG00000018204|UniProtKB=Q9BE40	Myosin-1	IC	89264452	PubMed	PTHR13140:SF484	MYOSIN-1
P02757	O-antigen biosynthesis	P03049	Glucosamine-1-phosphate acetyltransferase	THEMA|EnsemblGenome=TM_1629|UniProtKB=Q9X1W4	Bifunctional protein GlmU	ISS			PTHR43584:SF3	BIFUNCTIONAL PROTEIN GLMU
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	TAKRU|Ensembl=ENSTRUG00000007478|UniProtKB=H2T1I6	Uncharacterized protein	ISS	10092204	PubMed	PTHR43940:SF5	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01001	KA4	HUMAN|HGNC=4582|UniProtKB=Q16099	Glutamate receptor ionotropic, kainate 4	IC	12778120	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00006	Apoptosis signaling pathway	P00315	RIP	PANTR|Ensembl=ENSPTRG00000017672|UniProtKB=H2QS79	Receptor (TNFRSF)-interacting serine-threonine kinase 1	ISS	7538908	PubMed	PTHR44738:SF1	RECEPTOR-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CIOIN|Ensembl=ENSCING00000000848|UniProtKB=F6SCP4	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS			PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00018	EGF receptor signaling pathway	P00557	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	ISS	14526383	PubMed	PTHR10048:SF14	PI-3 KINASE
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05916	Opioid prodynorphin pathway	P06002	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	15737619	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	MACMU|Ensembl=ENSMMUG00000004329|UniProtKB=F6ZDV3	Excitatory amino acid transporter 2 isoform 1	ISS	94365697	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01080	AChE	DANRE|ZFIN=ZDB-GENE-010906-1|UniProtKB=Q9DDE3	Acetylcholinesterase	ISS	86008285	PubMed	PTHR43918:SF3	ACETYLCHOLINESTERASE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00034	Integrin signalling pathway	P00931	Integrin beta	CANLF|Ensembl=ENSCAFG00000009877|UniProtKB=E2RBL9	Integrin beta	ISS	3487386	PubMed	PTHR10082:SF11	INTEGRIN BETA-6
P00021	FGF signaling pathway	P00644	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IGI	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	RAT|RGD=620196|UniProtKB=P23097	Collagenase 3 (Fragment)	TAS	91093077	PubMed	PTHR10201:SF165	COLLAGENASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DROME|FlyBase=FBgn0000047|UniProtKB=P83967	Actin, indirect flight muscle	IDA	11889126	PubMed	PTHR11937:SF368	ACTIN, INDIRECT FLIGHT MUSCLE
P00019	Endothelin signaling pathway	P00583	cPLA2	PANTR|Ensembl=ENSPTRG00000001787|UniProtKB=H2Q0T0	Phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000005792|UniProtKB=F6VTR8	Uncharacterized protein	ISS	129387	gi	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00048	PI3 kinase pathway	P01196	PDK1	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	BOVIN|Ensembl=ENSBTAG00000019021|UniProtKB=F1MJ34	Uncharacterized protein	ISS	11055438	PubMed	PTHR10117:SF8	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 3
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	BRAFL|Gene=BRAFLDRAFT_220697|UniProtKB=C3ZSF0	Putative uncharacterized protein	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00057	Wnt signaling pathway	P01472	Histone deacetylase	USTMA|Gene=UMAG_02065|UniProtKB=A0A0D1E0Y7	Chromosome 5, whole genome shotgun sequence	IDA	10485845	PubMed	PTHR10625:SF141	HISTONE DEACETYLASE RPD3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00224	PDGF	MOUSE|MGI=MGI=1919035|UniProtKB=Q925I7	Platelet-derived growth factor D	ISS			PTHR11633:SF4	PLATELET-DERIVED GROWTH FACTOR D
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05731	GABA-B receptor II signaling	P05754	Ggamma	CANLF|Ensembl=ENSCAFG00000002046|UniProtKB=E2RBE7	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P06959	CCKR signaling map	P07063	MAP3K14	HUMAN|HGNC=6853|UniProtKB=Q99558	Mitogen-activated protein kinase kinase kinase 14	RCA	10094049	PubMed	PTHR24361:SF226	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 14
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00052	TGF-beta signaling pathway	P01292	RSmads	ORNAN|Ensembl=ENSOANG00000006538|UniProtKB=F6YA42	Mothers against decapentaplegic homolog	ISS	12736218	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P04395	Vasopressin synthesis	P04597	Signal Peptide	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00046	Oxidative stress response	P01135	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	TAKRU|Ensembl=ENSTRUG00000016101|UniProtKB=H2UW32	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	12805548	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01173	STAT	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	YEAST|SGD=S000003272|UniProtKB=P14681	Mitogen-activated protein kinase KSS1	ISS	12787066	PubMed	PTHR24055:SF338	MITOGEN-ACTIVATED PROTEIN KINASE KSS1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00006	Apoptosis signaling pathway	P00321	HSP70	TAKRU|Ensembl=ENSTRUG00000002095|UniProtKB=H2RXF2	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF256	HSP70 PROTEIN-RELATED
P06664	Gonadotropin-releasing hormone receptor pathway	P06738	PLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	RCA	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00010	B cell activation	P00388	PLC gamma2	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	IGI	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P02765	Phenylalanine biosynthesis	P03100	Chorismate mutase	ARATH|TAIR=AT5G10870|UniProtKB=Q9S7H4	Chorismate mutase 2	ISS			PTHR21145:SF1	CHORISMATE MUTASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	CANLF|Ensembl=ENSCAFG00000009203|UniProtKB=F1PVZ1	Muscarinic acetylcholine receptor	ISS	10069496	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00012	Cadherin signaling pathway	P00475	Frizzled	MACMU|Ensembl=ENSMMUG00000004048|UniProtKB=F6ZR92	Frizzled-4	ISS	11212302	PubMed	PTHR11309:SF23	FRIZZLED-4
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00053	T cell activation	P01331	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IDA	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	IDA	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00054	Toll receptor signaling pathway	P01357	MEKK1	RAT|RGD=620966|UniProtKB=Q62925	Mitogen-activated protein kinase kinase kinase 1	ISS	8940199	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00045	Notch signaling pathway	P01120	NIcs	MACMU|Ensembl=ENSMMUG00000017022|UniProtKB=F7HQZ9	Uncharacterized protein	ISS	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	HUMAN|HGNC=10935|UniProtKB=Q05940	Synaptic vesicular amine transporter	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8691|UniProtKB=Q9Y5E3	Protocadherin beta-6	IDA	8120095	PubMed	PTHR24028:SF104	PROTOCADHERIN BETA-6
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05974	G-Protein (i)	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MONDO|Ensembl=ENSMODG00000001389|UniProtKB=F7BD45	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF657	MYOSIN-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MACMU|Ensembl=ENSMMUG00000010392|UniProtKB=F7ASR8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Ensembl=ENSBTAG00000013202|UniProtKB=Q1RML2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1	ISS	12860966	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P06959	CCKR signaling map	P07128	Pre-pro CCK @ ER	HUMAN|HGNC=1569|UniProtKB=P06307	Cholecystokinin	RCA	12479974	PubMed	PTHR10786:SF0	CHOLECYSTOKININ
P00007	Axon guidance mediated by semaphorins	P00339	CRMP	MACMU|Ensembl=ENSMMUG00000012718|UniProtKB=F7DF35	Uncharacterized protein	ISS	7637782	PubMed	PTHR11647:SF56	DIHYDROPYRIMIDINASE-RELATED PROTEIN 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00020	FAS signaling pathway	P00615	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	HUMAN|HGNC=10001|UniProtKB=O15539	Regulator of G-protein signaling 5	IDA	8756726	PubMed	PTHR10845:SF42	REGULATOR OF G-PROTEIN SIGNALING 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04393	Ras Pathway	P04550	Ral	HUMAN|HGNC=9839|UniProtKB=P11233	Ras-related protein Ral-A	ISS	11025226	PubMed	PTHR24070:SF174	RAS-RELATED PROTEIN RAL-A
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	RAT|RGD=1307644|UniProtKB=D3ZND6	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00030	Hypoxia response via HIF activation	P00819	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	TAS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	RCA	2372396	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00053	T cell activation	P01300	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	XENTR|Xenbase=XB-GENE-480347|UniProtKB=Q6P640	Actin, alpha cardiac muscle 1	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P06587	Nicotine pharmacodynamics pathway	P06614	TH	MACMU|Ensembl=ENSMMUG00000003912|UniProtKB=F6ZV38	Uncharacterized protein	ISS	12480184	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04398	p53 pathway feedback loops 2	P04665	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00029	Huntington disease	P00778	NMDA receptor	CANLF|Ensembl=ENSCAFG00000013148|UniProtKB=Q5R1P3	Glutamate receptor ionotropic, NMDA 2B	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00059	p53 pathway	G04702	p53	MACMU|Ensembl=ENSMMUG00000016569|UniProtKB=F6VXE7	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	SCHPO|PomBase=SPAC8C9.03|UniProtKB=P36600	cAMP-dependent protein kinase regulatory subunit	IC	2372396	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00053	T cell activation	P01300	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00059	p53 pathway	G01579	PTEN	TAKRU|Ensembl=ENSTRUG00000009851|UniProtKB=H2TJ90	Uncharacterized protein	IGI	21455682	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00020	FAS signaling pathway	P00614	ASK1	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS			PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02767	Phenylpropionate degradation	P03106	4-Hydroxy-2-ketovalerate aldolase	STRCO|EnsemblGenome=CAC36575|UniProtKB=Q99PZ1	4-hydroxy-2-oxovalerate aldolase	ISS			PTHR10277:SF3	4-HYDROXY-2-OXOVALERATE ALDOLASE
P00013	Cell cycle	P00480	Proteasome	MOUSE|MGI=MGI=1201670|UniProtKB=O35226	26S proteasome non-ATPase regulatory subunit 4	ISS	11827521	PubMed	PTHR10223:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IC	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00059	p53 pathway	P01486	Akt	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	TAS	12719720	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00047	PDGF signaling pathway	P01160	IP3 receptor	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00060	Ubiquitin proteasome pathway	P01490	E3	XENTR|Xenbase=XB-GENE-948557|UniProtKB=F6U235	Uncharacterized protein	ISS			PTHR11254:SF301	UBIQUITIN-PROTEIN LIGASE E3A
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	ORNAN|Ensembl=ENSOANG00000011166|UniProtKB=F7D5G3	Phosphoinositide phospholipase C	ISS			PTHR10336:SF84	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	15313841	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_58093|UniProtKB=C3Z4K3	Putative uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02725	Allantoin degradation	P02819	Glyoxylate carboligase	PSEAE|EnsemblGenome=PA1502|UniProtKB=Q9I3L0	Glyoxylate carboligase	ISS			PTHR18968:SF14	GLYOXYLATE CARBOLIGASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MOUSE|MGI=MGI=95821|UniProtKB=Q01097	Glutamate receptor ionotropic, NMDA 2B	IC	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P02721	ATP synthesis	P02798	Cyt C	MACMU|Ensembl=ENSMMUG00000032513|UniProtKB=G1K372	Uncharacterized protein	ISS	4954366	PubMed	PTHR11961:SF15	CYTOCHROME C
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	RAT|RGD=621399|UniProtKB=D3ZWL1	Protein Skil	ISS	10485843	PubMed	PTHR10005:SF3	SKI-LIKE PROTEIN
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	TAS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00790	beta-Tubulin	CAEBR|Gene=CBG18319|UniProtKB=A8XSF1	Protein CBR-TBB-1	ISS	9454836	PubMed	PTHR11588:SF157	TUBULIN, BETA
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04569	Cdc42	PRIPA|Gene=PPA22610|UniProtKB=H3FK05	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF192	CDC42 HOMOLOG
P00057	Wnt signaling pathway	P01451	Galpha	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IDA	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00005	Angiogenesis	P00219	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MACMU|Ensembl=ENSMMUG00000000893|UniProtKB=F6T7D0	Histone acetyltransferase p300	ISS	10769018	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	LEIMA|EnsemblGenome=LmjF.09.0910|UniProtKB=Q4QHT2	Putative calmodulin	ISS	10487978	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00023	General transcription regulation	P00668	TFIIB	BRAFL|Gene=BRAFLDRAFT_118777|UniProtKB=C3ZB94	Putative uncharacterized protein	ISS			PTHR12458:SF8	CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00053	T cell activation	P01332	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	XENTR|Xenbase=XB-GENE-494200|UniProtKB=F7CS79	Uncharacterized protein	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000023046|UniProtKB=F6V829	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEEL|WormBase=WBGene00004033|UniProtKB=P90980	Protein kinase C-like 2	ISS	15572354	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=1756|UniProtKB=Q12864	Cadherin-17	IDA	8120095	PubMed	PTHR44603:SF2	CADHERIN-17
P00005	Angiogenesis	P00180	Dok-R	MACMU|Ensembl=ENSMMUG00000023464|UniProtKB=F7EZV2	Uncharacterized protein	ISS			PTHR21258:SF14	DOCKING PROTEIN 2
P00021	FGF signaling pathway	P00633	Ras	XENTR|Xenbase=XB-GENE-494548|UniProtKB=F7EC26	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Gene=DRD2|UniProtKB=P20288	D(2) dopamine receptor	IDA	2137198	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00034	Integrin signalling pathway	P00907	ERK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS			PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	GIAIC|EnsemblGenome=GL50803_40817|UniProtKB=A8BV70	Actin related protein	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00034	Integrin signalling pathway	P00942	Fyn	MOUSE|MGI=MGI=95602|UniProtKB=P39688	Tyrosine-protein kinase Fyn	IPI	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P05918	p38 MAPK pathway	P06020	p38delta	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	RCA	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P02738	De novo purine biosynthesis	P02909	GDP reductase	DANRE|ZFIN=ZDB-GENE-990415-25|UniProtKB=P79733	Ribonucleoside-diphosphate reductase subunit M2	ISS			PTHR23409:SF20	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00029	Huntington disease	P00811	Arp2/3 complex	RAT|RGD=1311791|UniProtKB=Q4KLF8	Actin-related protein 2/3 complex subunit 5	ISS	12473693	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00057	Wnt signaling pathway	P01428	Frizzled	MOUSE|MGI=MGI=1313278|UniProtKB=Q9R216	Frizzled-9	IDA	8717036	PubMed	PTHR11309:SF79	FRIZZLED-9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00833	RGS	PANTR|Ensembl=ENSPTRG00000001791|UniProtKB=H2R8B2	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF32	REGULATOR OF G-PROTEIN SIGNALING 13
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	CANLF|Gene=ADCY6|UniProtKB=P30804	Adenylate cyclase type 6	IC	2491850	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00059	p53 pathway	P04633	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00024	Glycolysis	P00677	Hexokinase	MOUSE|MGI=MGI=96103|UniProtKB=P17710	Hexokinase-1	IDA	11835228	PubMed	PTHR19443:SF10	HEXOKINASE-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	IDA	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00005	Angiogenesis	P00221	JNK1	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	ISS	8946915	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00020	FAS signaling pathway	P00622	FADD	MOUSE|MGI=MGI=109324|UniProtKB=Q61160	FAS-associated death domain protein	IGI	9506948	PubMed	PTHR15077:SF8	FAS-ASSOCIATED DEATH DOMAIN PROTEIN
P04397	p53 pathway by glucose deprivation	P04641	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	ISS	2842690	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00029	Huntington disease	P00799	JNK-2	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02770	Pyridoxal phosphate salvage pathway	P03120	Pyridoxamine-5-phosphate oxidase	SYNY3|EnsemblGenome=BAA18303|UniProtKB=P74211	Pyridoxine/pyridoxamine 5'-phosphate oxidase	ISS	8590279	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00048	PI3 kinase pathway	P01177	P110ACT	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MOUSE|MGI=MGI=1928375|UniProtKB=Q9JM76	Actin-related protein 2/3 complex subunit 3	ISS	9359840	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000014751|UniProtKB=H2R8D8	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00052	TGF-beta signaling pathway	P01288	FKBP12	MOUSE|MGI=MGI=1336205|UniProtKB=Q9Z2I2	Peptidyl-prolyl cis-trans isomerase FKBP1B	ISS			PTHR10516:SF309	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1B
P00005	Angiogenesis	P00206	Wnt	MACMU|Ensembl=ENSMMUG00000009980|UniProtKB=F6R3A1	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00018	EGF receptor signaling pathway	P00559	MEK1-2	ARATH|TAIR=AT5G56580|UniProtKB=Q9FJV0	Mitogen-activated protein kinase kinase 6	ISS			PTHR24361:SF616	MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=98960|UniProtKB=P22727	Protein Wnt-6	IDA	11266476	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P00048	PI3 kinase pathway	P01199	Galpha	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00017	DNA replication	P00535	5' to 3' Exoribonulcease	PANTR|Ensembl=ENSPTRG00000013308|UniProtKB=H2QK18	5'-3' exoribonuclease 2	ISS	7885830	PubMed	PTHR12341:SF41	5'-3' EXORIBONUCLEASE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00029	Huntington disease	P00787	MAPKK4	HUMAN|HGNC=6844|UniProtKB=P45985	Dual specificity mitogen-activated protein kinase kinase 4	NAS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00048	PI3 kinase pathway	P01190	PDK1 ACT	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	12855688	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00057	Wnt signaling pathway	P01438	PP2A	TAKRU|Ensembl=ENSTRUG00000011169|UniProtKB=H2TU36	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	BOVIN|Ensembl=ENSBTAG00000003054|UniProtKB=F1MC23	Tyrosine-protein kinase receptor	ISS	12644000	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00005	Angiogenesis	P00223	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CAEEL|WormBase=WBGene00006932|UniProtKB=Q9TXI7	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P02769	Purine metabolism	P03119	5'-Nucleotidase	RAT|RGD=61956|UniProtKB=P21588	5'-nucleotidase	NAS	8224905	PubMed	PTHR11575:SF25	5'-NUCLEOTIDASE
P00046	Oxidative stress response	P01131	MKP5	HUMAN|HGNC=3068|UniProtKB=Q05923	Dual specificity protein phosphatase 2	TAS			PTHR10159:SF109	DUAL SPECIFICITY PROTEIN PHOSPHATASE 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MACMU|Ensembl=ENSMMUG00000016376|UniProtKB=F7G2W1	Uncharacterized protein	ISS	12968034	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P04397	p53 pathway by glucose deprivation	P04641	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00163	Erb-B4 C-terminal fragment	MONDO|Ensembl=ENSMODG00000015755|UniProtKB=F6ZSZ9	Uncharacterized protein (Fragment)	ISS	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	HUMAN|HGNC=705|UniProtKB=O15144	Actin-related protein 2/3 complex subunit 2	ISS	12473693	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00017	DNA replication	P00531	Pol alpha	LEIMA|EnsemblGenome=LmjF.16.1540|UniProtKB=Q4QEL1	DNA polymerase	ISS	97312527	PubMed	PTHR10322:SF21	DNA POLYMERASE ALPHA CATALYTIC SUBUNIT
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	TAKRU|Ensembl=ENSTRUG00000004787|UniProtKB=P53480	Actin, alpha cardiac	ISS	11889139	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00053	T cell activation	P01331	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=620027|UniProtKB=P08911	Muscarinic acetylcholine receptor M5	IDA			PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P02731	Biotin biosynthesis	P02857	Biotin synthase	METAC|EnsemblGenome=MA_0154|UniProtKB=Q8TUB9	3-methylornithine synthase	ISS			PTHR43726:SF1	SUBFAMILY NOT NAMED
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00005	Angiogenesis	P00243	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01167	Ets	MOUSE|MGI=MGI=95554|UniProtKB=P26323	Friend leukemia integration 1 transcription factor	ISS	15298723	PubMed	PTHR11849:SF161	FRIEND LEUKEMIA INTEGRATION 1 TRANSCRIPTION FACTOR
P05913	Enkephalin release	P05972	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	HUMAN|HGNC=1076|UniProtKB=P36894	Bone morphogenetic protein receptor type-1A	TAS	10683140	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P00041	Metabotropic glutamate receptor group I pathway	P01062	mGluR1	PANTR|Ensembl=ENSPTRG00000018684|UniProtKB=C7G3M7	Glutamate receptor, metabotropic 1	ISS	9407094	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	IC	8838325	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	HUMAN|HGNC=1950|UniProtKB=P11229	Muscarinic acetylcholine receptor M1	IDA	8100450	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00752	cGMP-gated ion channel	MACMU|Ensembl=ENSMMUG00000021187|UniProtKB=F7GZN6	Uncharacterized protein	ISS	12432397	PubMed	PTHR10217:SF390	CYCLIC NUCLEOTIDE-GATED CATION CHANNEL ALPHA-3
P00005	Angiogenesis	P00203	Erk	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00786	ARF	MONDO|Ensembl=ENSMODG00000023914|UniProtKB=F7FYA6	Uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	MONDO|Ensembl=ENSMODG00000015970|UniProtKB=F7FD05	Uncharacterized protein	ISS	11752053	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00047	PDGF signaling pathway	P01154	Ras	DANRE|ZFIN=ZDB-GENE-040426-2860|UniProtKB=Q1LVZ0	Uncharacterized protein	ISS			PTHR24073:SF335	RAS-RELATED PROTEIN RAB-11B
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CAEEL|WormBase=WBGene00001612|UniProtKB=P34299	Glutamate receptor 1	IC	8804111	PubMed	PTHR18966:SF297	GLUTAMATE RECEPTOR 1
P00059	p53 pathway	P04623	CBP	PANTR|Ensembl=ENSPTRG00000002652|UniProtKB=H2Q248	Histone acetyltransferase	ISS	10769018	PubMed	PTHR10615:SF73	HISTONE ACETYLTRANSFERASE KAT6B
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02738	De novo purine biosynthesis	P02905	Amidophosphoribosyl transferase	BOVIN|Ensembl=ENSBTAG00000010571|UniProtKB=F1MV22	Amidophosphoribosyltransferase	ISS			PTHR11907:SF18	AMIDOPHOSPHORIBOSYLTRANSFERASE
P00019	Endothelin signaling pathway	P00586	Gq	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	TAS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	PANTR|Ensembl=ENSPTRG00000000290|UniProtKB=H2PY87	Cytidine deaminase	ISS	12844405	PubMed	PTHR11644:SF2	CYTIDINE DEAMINASE
P00021	FGF signaling pathway	P00645	Rac	CAEEL|WormBase=WBGene00000424|UniProtKB=Q03206	Ras-related protein ced-10	IGI	4757952	gi	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P05917	Opioid proopiomelanocortin pathway	P06011	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	XENTR|Ensembl=ENSXETG00000030140|UniProtKB=F7EP58	Uncharacterized protein (Fragment)	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MACMU|Ensembl=ENSMMUG00000010392|UniProtKB=F7ASR8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00049	Parkinson disease	P01211	ERK	DICDI|dictyBase=DDB_G0283903|UniProtKB=Q54QB1	Extracellular signal-regulated kinase 2	IDA	95146547	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P05918	p38 MAPK pathway	P06021	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00036	Interleukin signaling pathway	P00965	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IC	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00635	FRS2	MOUSE|MGI=MGI=2135965|UniProtKB=Q91WJ0	Fibroblast growth factor receptor substrate 3	ISS			PTHR21258:SF39	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 3
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00048	PI3 kinase pathway	P01206	14-3-3	CANLF|Ensembl=ENSCAFG00000000580|UniProtKB=F1PBL1	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00021	FGF signaling pathway	P00633	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00049	Parkinson disease	P01208	Hsp70	YEAST|SGD=S000002388|UniProtKB=P11484	Heat shock protein SSB1	IDA	12150907	PubMed	PTHR19375:SF256	HSP70 PROTEIN-RELATED
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	HUMAN|HGNC=19663|UniProtKB=Q9UBI6	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	DANRE|ZFIN=ZDB-GENE-030131-7595|UniProtKB=Q6PBR4	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00036	Interleukin signaling pathway	P00981	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	DANRE|ZFIN=ZDB-GENE-081003-1|UniProtKB=B0LK22	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00034	Integrin signalling pathway	P00948	Rho	PANTR|Ensembl=ENSPTRG00000001112|UniProtKB=H2PZP2	Ras homolog gene family, member C	ISS	14871999	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	ORYSJ|EnsemblGenome=OS06G0270900|UniProtKB=Q9FRX7	Aldehyde dehydrogenase ALDH2b	IC			PTHR11699:SF211	ALDEHYDE DEHYDROGENASE 5, MITOCHONDRIAL
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=3346|UniProtKB=P10688	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	7822322	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	BOVIN|Ensembl=ENSBTAG00000017616|UniProtKB=A5PJR4	Adenylosuccinate synthetase isozyme 1	ISS	10636885	PubMed	PTHR11846:SF2	ADENYLOSUCCINATE SYNTHETASE ISOZYME 1
P04393	Ras Pathway	P04543	MEKK1/4	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS	9079650	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00056	VEGF signaling pathway	P01425	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	3755548	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00057	Wnt signaling pathway	P01432	Beta-Catenin	TAKRU|Ensembl=ENSTRUG00000003520|UniProtKB=H2S791	Uncharacterized protein	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00021	FGF signaling pathway	P00636	FGFR1-4	MACMU|Ensembl=ENSMMUG00000019945|UniProtKB=F7FZS3	Fibroblast growth factor receptor	ISS	14520460	PubMed	PTHR24416:SF505	FIBROBLAST GROWTH FACTOR RECEPTOR 3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000002647|UniProtKB=F7DIB7	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DROME|FlyBase=FBgn0031106|UniProtKB=Q9VR90	Syntaxin 16	IC			PTHR19957:SF83	SYNTAXIN-16
P00018	EGF receptor signaling pathway	P00551	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	IGI	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IGI	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01199	Galpha	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	IC	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	HUMAN|HGNC=4597|UniProtKB=P41594	Metabotropic glutamate receptor 5	IDA	14614461	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01173	STAT	CANLF|Ensembl=ENSCAFG00000015509|UniProtKB=F1PNW8	Signal transducer and activator of transcription	ISS	10835485	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00057	Wnt signaling pathway	P01444	Wnt	DANRE|ZFIN=ZDB-GENE-980526-526|UniProtKB=P24257	Protein Wnt-1	IDA	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05918	p38 MAPK pathway	P05920	MAPKAP-K2	MOUSE|MGI=MGI=109298|UniProtKB=P49138	MAP kinase-activated protein kinase 2	RCA	14672329	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IDA	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PANTR|Ensembl=ENSPTRG00000006890|UniProtKB=H2Q943	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00021	FGF signaling pathway	P00627	ERK1-2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01238	14-3-3	RAT|RGD=3978|UniProtKB=P68511	14-3-3 protein eta	ISS	10407019	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	CAEBR|Gene=CBG18000|UniProtKB=A8XSS7	Protein CBR-ACY-1	ISS	2491850	PubMed	PTHR11920:SF319	ADENYLATE CYCLASE TYPE 9
P00057	Wnt signaling pathway	P01435	SWI/SNF	MACMU|Ensembl=ENSMMUG00000006687|UniProtKB=F7H1V4	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 isoform 2	ISS	11532957	PubMed	PTHR13844:SF5	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D MEMBER 3
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IPI	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	DROME|FlyBase=FBgn0040299|UniProtKB=Q8IPH8	Myosin 28B1, isoform B	IC			PTHR13140:SF703	MYOSIN 28B1, ISOFORM B-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	IDA	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	TAS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00054	Toll receptor signaling pathway	P01342	IRAK4	RAT|RGD=1305303|UniProtKB=D4A7K4	Protein Irak4	ISS			PTHR24419:SF22	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	18479080	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00029	Huntington disease	P00811	Arp2/3 complex	HUMAN|HGNC=704|UniProtKB=O15143	Actin-related protein 2/3 complex subunit 1B	TAS	12932731	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00059	p53 pathway	P04622	Sin3	MACMU|Ensembl=ENSMMUG00000009281|UniProtKB=F7H3V1	Paired amphipathic helix protein Sin3a	ISS	10441327	PubMed	PTHR12346:SF2	PAIRED AMPHIPATHIC HELIX PROTEIN SIN3A
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00047	PDGF signaling pathway	P01154	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00010	B cell activation	P00384	p38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	PANTR|Ensembl=ENSPTRG00000013022|UniProtKB=H2QJL0	Uncharacterized protein	ISS			PTHR24247:SF31	5-HYDROXYTRYPTAMINE RECEPTOR 2B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	DANRE|Ensembl=ENSDARG00000059090|UniProtKB=E7FDL0	Uncharacterized protein	ISS	12562507	PubMed	PTHR24229:SF75	SUBFAMILY NOT NAMED
P00059	p53 pathway	G01579	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00005	Angiogenesis	P00211	GSK3beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MACMU|Ensembl=ENSMMUG00000014597|UniProtKB=F6VAQ6	Glycogen synthase kinase-3 alpha	ISS	14698990	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P05730	Endogenous cannabinoid signaling	P05746	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Gene=PCDHB9|UniProtKB=Q5DRC4	Protocadherin beta-9	ISS	8120095	PubMed	PTHR24028:SF128	PROTOCADHERIN BETA-9
P04398	p53 pathway feedback loops 2	P04665	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01444	Wnt	PANTR|Ensembl=ENSPTRG00000002849|UniProtKB=H2Q2F4	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00012	Cadherin signaling pathway	P00470	F-actin	DAPPU|EnsemblGenome=DAPPUDRAFT_228751|UniProtKB=E9HGF5	Cytoplasmatic actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00036	Interleukin signaling pathway	P00981	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IC	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	91056091	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00021	FGF signaling pathway	P00627	ERK1-2	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000016761|UniProtKB=H2R1Q6	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF322	CADHERIN-6
P00057	Wnt signaling pathway	P01428	Frizzled	HUMAN|HGNC=4042|UniProtKB=Q9ULV1	Frizzled-4	IDA	11212302	PubMed	PTHR11309:SF23	FRIZZLED-4
P00034	Integrin signalling pathway	P00925	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00005	Angiogenesis	P00256	PLC-gamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MOUSE|MGI=MGI=87906|UniProtKB=P63260	Actin, cytoplasmic 2	ISS	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00024	Glycolysis	P00678	Enolase	ORNAN|Ensembl=ENSOANG00000013484|UniProtKB=F7FAQ8	Uncharacterized protein (Fragment)	ISS	99439677	PubMed	PTHR11902:SF12	ALPHA-ENOLASE
P00047	PDGF signaling pathway	P01160	IP3 receptor	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00005	Angiogenesis	P00234	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8051109	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00049	Parkinson disease	P01211	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	21150461	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00053	T cell activation	P01322	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	15860573	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00010	B cell activation	P00371	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00577	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IGI	7565716	PubMed	PTHR10048:SF14	PI-3 KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00090	MDC9	XENTR|Xenbase=XB-GENE-976453|UniProtKB=F6RT57	Uncharacterized protein	ISS	10510302	PubMed	PTHR11905:SF136	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 9
P00048	PI3 kinase pathway	P01177	P110ACT	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	IGI	129387	gi	PTHR10048:SF14	PI-3 KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IDA	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00015	Circadian clock system	P00505	Cry	MACMU|Ensembl=ENSMMUG00000021808|UniProtKB=F7ENG9	Cryptochrome-1	ISS	10428031	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P05913	Enkephalin release	P05978	AC	RAT|RGD=619966|UniProtKB=F1LQT1	Adenylate cyclase 7	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	TAS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00036	Interleukin signaling pathway	P00968	Ikk	PANTR|Ensembl=ENSPTRG00000020202|UniProtKB=H2QW34	Uncharacterized protein	ISS	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00029	Huntington disease	P00767	Pro-caspase 8	HUMAN|HGNC=1509|UniProtKB=Q14790	Caspase-8	IDA	11788820	PubMed	PTHR10454:SF162	CASPASE-8
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00131	HAC1	MOUSE|MGI=MGI=1933163|UniProtKB=Q9ESN6	Tripartite motif-containing protein 2	IDA			PTHR44028:SF2	TRIPARTITE MOTIF-CONTAINING PROTEIN 2
P00018	EGF receptor signaling pathway	P00552	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00048	PI3 kinase pathway	P01199	Galpha	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00036	Interleukin signaling pathway	P00965	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IC	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00018	EGF receptor signaling pathway	P00561	STAT	PANTR|Ensembl=ENSPTRG00000005121|UniProtKB=H2Q6A5	Uncharacterized protein	ISS	94367369	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00059	p53 pathway	P04610	Cyclin E	PANTR|Ensembl=ENSPTRG00000010782|UniProtKB=H2R677	Cyclin E1	ISS	12729791	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00006	Apoptosis signaling pathway	P00269	MAPK	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF330	SUBFAMILY NOT NAMED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05923	beta-ARR2	PANTR|Ensembl=ENSPTRG00000008601|UniProtKB=H2QBY1	Arrestin, beta 2	ISS	11742073	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	BOVIN|Ensembl=ENSBTAG00000011757|UniProtKB=Q9XT97	Presenilin-1	TAS	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P00048	PI3 kinase pathway	P01179	PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00931	Integrin beta	HUMAN|HGNC=6158|UniProtKB=P16144	Integrin beta-4	IDA	3487386	PubMed	PTHR10082:SF42	INTEGRIN BETA-4
P00057	Wnt signaling pathway	P01438	PP2A	MACMU|Ensembl=ENSMMUG00000008205|UniProtKB=F7GWP9	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	ISS	8703017	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00019	Endothelin signaling pathway	P00573	signal peptidase	ARATH|TAIR=AT1G52600|UniProtKB=Q9SSR2	Signal peptidase I	ISS	2674115	PubMed	PTHR10806:SF16	SIGNAL PEPTIDASE I
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	RCA	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00373	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01331	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00948	Rho	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	IGI	11360179	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IC	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00035	Interferon-gamma signaling pathway	P00952	Jak2	BOVIN|Ensembl=ENSBTAG00000012047|UniProtKB=E1BCP6	Tyrosine-protein kinase	ISS	22482294	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	ISS	11889139	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00059	p53 pathway	P04609	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	96009592	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05730	Endogenous cannabinoid signaling	P05751	Galpha	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01058	Homer	CHICK|Ensembl=ENSGALG00000014813|UniProtKB=F1NBG3	Uncharacterized protein	ISS	12653978	PubMed	PTHR10918:SF3	HOMER PROTEIN HOMOLOG 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000003236|UniProtKB=F7DNS6	Uncharacterized protein	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00018	EGF receptor signaling pathway	P00564	Rac	DICPU|Gene=DICPUDRAFT_168754|UniProtKB=F0ZQR3	Rac1B, RHO family GTPase	ISS	12932731	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00057	Wnt signaling pathway	P01443	Phospholipase C	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	HUMAN|HGNC=1078|UniProtKB=Q13873	Bone morphogenetic protein receptor type-2	TAS	9395284	PubMed	PTHR23255:SF63	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00006	Apoptosis signaling pathway	P00260	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P06664	Gonadotropin-releasing hormone receptor pathway	P06773	gnai/o	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04395	Vasopressin synthesis	P04593	Glycopeptide	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00059	p53 pathway	P01486	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	14744428	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	PLAF7|EnsemblGenome=PFI1685w|UniProtKB=Q7K6A0	cAMP-dependent protein kinase catalytic subunit	ISS			PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00036	Interleukin signaling pathway	P00967	c-fos	PANTR|Ensembl=ENSPTRG00000006553|UniProtKB=A5A6H0	C-fos	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00029	Huntington disease	P00807	Actin	ARATH|TAIR=AT3G46520|UniProtKB=P53497	Actin-12	IDA	11889126	PubMed	PTHR11937:SF276	ACTIN-12
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00269	MAPK	CHLRE|EnsemblGenome=CHLREDRAFT_193901|UniProtKB=Q9FXT7	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04395	Vasopressin synthesis	P04593	Glycopeptide	HUMAN|HGNC=8528|UniProtKB=P01178	Oxytocin-neurophysin 1	IC	1706187	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P04398	p53 pathway feedback loops 2	P04658	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00053	T cell activation	P01322	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IDA	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MOUSE|MGI=MGI=95770|UniProtKB=P30678	Guanine nucleotide-binding protein subunit alpha-15	IDA	8838318	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P00049	Parkinson disease	P01208	Hsp70	CANLF|Ensembl=ENSCAFG00000000641|UniProtKB=G1K268	Uncharacterized protein	IDA	12150907	PubMed	PTHR19375:SF223	HEAT SHOCK 70 KDA PROTEIN 1A-RELATED
P00001	Adrenaline and noradrenaline biosynthesis	P00071	VAT1	HUMAN|HGNC=10934|UniProtKB=P54219	Chromaffin granule amine transporter	ISS	12135927	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	CAEEL|WormBase=WBGene00001620|UniProtKB=Q10901	Excitatory amino acid transporter	ISS	94365697	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00059	p53 pathway	P04633	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	DROME|FlyBase=FBgn0004623|UniProtKB=P29829	Guanine nucleotide-binding protein subunit beta-2	IC			PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00029	Huntington disease	P00805	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02742	Tetrahydrofolate biosynthesis	P02944	Phosphoribosylglycinamide formyltransferase	SYNY3|EnsemblGenome=BAA10270|UniProtKB=Q55135	Formyltetrahydrofolate deformylase	ISS			PTHR42706:SF1	FORMYLTETRAHYDROFOLATE DEFORMYLASE 1, MITOCHONDRIAL-RELATED
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000010266|UniProtKB=F6PV18	Uncharacterized protein	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P06664	Gonadotropin-releasing hormone receptor pathway	P06819	SMAD2-4	MOUSE|MGI=MGI=109452|UniProtKB=P70340	Mothers against decapentaplegic homolog 1	RCA	9395284	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	RAT|RGD=2248|UniProtKB=P54287	Voltage-dependent L-type calcium channel subunit beta-3	IC			PTHR11824:SF8	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	BOVIN|Ensembl=ENSBTAG00000047202|UniProtKB=G3N3K3	Uncharacterized protein	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00059	p53 pathway	P04625	Cdk2	BOVIN|Ensembl=ENSBTAG00000004021|UniProtKB=Q5E9Y0	Cyclin-dependent kinase 2	ISS	15660127	PubMed	PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	RCA	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MACMU|Ensembl=ENSMMUG00000010392|UniProtKB=F7ASR8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00560	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	RAT|RGD=1305499|UniProtKB=Q5U206	Calmodulin-like protein 3	ISS	9753452	PubMed	PTHR23050:SF197	CALMODULIN-LIKE PROTEIN 3
P00057	Wnt signaling pathway	P01444	Wnt	CAEEL|WormBase=WBGene00001188|UniProtKB=G5EG05	Uncharacterized protein	IDA	11266476	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P00010	B cell activation	P00368	vav	RAT|RGD=1565941|UniProtKB=F1LWB1	Protein Vav3	ISS	14623913	PubMed	PTHR22826:SF97	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3
P00029	Huntington disease	P00811	Arp2/3 complex	PANTR|Ensembl=ENSPTRG00000019449|UniProtKB=H2QV01	Actin related protein 2/3 complex, subunit 1B, 41kDa	ISS	12963527	gi	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00059	p53 pathway	P04633	P110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02775	Salvage pyrimidine ribonucleotides	P03155	Cytosine deaminase	SYNY3|Gene=BAA17764|UniProtKB=P73717	tRNA-specific adenosine deaminase	ISS			PTHR11079:SF149	TRNA-SPECIFIC ADENOSINE DEAMINASE
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	7925653	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	DROME|FlyBase=FBgn0003275|UniProtKB=Q24320	DNA-directed RNA polymerases I, II, and III subunit RPABC2	ISS	717184	gi	PTHR10773:SF12	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	YEAST|SGD=S000000028|UniProtKB=P31109	Synaptobrevin homolog 1	ISS			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P02722	Acetate utilization	P02802	Phosphate acetyltransferase	ECOLI|EcoGene=EG14188|UniProtKB=P77218	Ethanolamine utilization protein EutD	ISS			PTHR43356:SF1	ETHANOLAMINE UTILIZATION PROTEIN EUTD
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00045	Notch signaling pathway	P01101	Su(H)	MONDO|Ensembl=ENSMODG00000000129|UniProtKB=F6YB95	Uncharacterized protein	ISS	9043084	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00048	PI3 kinase pathway	P01192	p110	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00029	Huntington disease	P00778	NMDA receptor	MOUSE|MGI=MGI=2150393|UniProtKB=Q91ZU9	Glutamate receptor ionotropic, NMDA 3B	IDA	11319238	PubMed	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	TAS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00990	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00562	p38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00054	Toll receptor signaling pathway	P01368	MKK2	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00846	JAK	MOUSE|MGI=MGI=1929470|UniProtKB=Q9R117	Non-receptor tyrosine-protein kinase TYK2	IDA	21866139	PubMed	PTHR24418:SF244	NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	HUMAN|HGNC=17780|UniProtKB=Q562R1	Beta-actin-like protein 2	ISS	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00005	Angiogenesis	P00249	PAK	HUMAN|HGNC=8592|UniProtKB=O75914	Serine/threonine-protein kinase PAK 3	ISS	11259591	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00052	TGF-beta signaling pathway	P01275	P38	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CHICK|Ensembl=ENSGALG00000001334|UniProtKB=F1NLV4	Uncharacterized protein	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P02738	De novo purine biosynthesis	P02909	GDP reductase	CHLTR|EnsemblGenome=CT_828|UniProtKB=O84835	Ribonucleoside-diphosphate reductase subunit beta	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00059	p53 pathway	P01486	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00381	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BOVIN|Ensembl=ENSBTAG00000014614|UniProtKB=P62739	Actin, aortic smooth muscle	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00047	PDGF signaling pathway	P01143	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	BOVIN|Ensembl=ENSBTAG00000016420|UniProtKB=Q0VCX4	Catenin beta-1	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	CANLF|Ensembl=ENSCAFG00000018564|UniProtKB=E2RHU1	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MONDO|Ensembl=ENSMODG00000021434|UniProtKB=F7CB49	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P02741	Flavin biosynthesis	P02939	Lumazine synthase	LEPIN|EnsemblGenome=LA_0463|UniProtKB=Q8F8T9	6,7-dimethyl-8-ribityllumazine synthase	ISS			PTHR21058:SF0	6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	RAT|RGD=619885|UniProtKB=P29411	GTP:AMP phosphotransferase AK3, mitochondrial	ISS			PTHR23359:SF68	GTP:AMP PHOSPHOTRANSFERASE AK3, MITOCHONDRIAL
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IGI	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	88241036	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	RAT|RGD=67385|UniProtKB=Q8VGC3	Voltage-dependent L-type calcium channel subunit beta-2	IC	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	96009592	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00010	B cell activation	P00383	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IDA	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	IDA	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00010	B cell activation	P00367	NFAT	PANTR|Ensembl=ENSPTRG00000006218|UniProtKB=H2Q834	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	HUMAN|HGNC=292|UniProtKB=P30520	Adenylosuccinate synthetase isozyme 2	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00034	Integrin signalling pathway	P00941	Integrin alpha	PANTR|Ensembl=ENSPTRG00000007215|UniProtKB=H2Q9P5	Integrin, alpha 11	ISS	3487386	PubMed	PTHR23220:SF21	INTEGRIN ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	PANTR|Ensembl=ENSPTRG00000006510|UniProtKB=H2Q8K1	Presenilin	ISS	12736250	PubMed	PTHR10202:SF18	PRESENILIN-1
P00054	Toll receptor signaling pathway	P01358	ERK1	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00005	Angiogenesis	P00221	JNK1	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=12785|UniProtKB=Q9Y6F9	Protein Wnt-6	TAS	8717036	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	HUMAN|HGNC=234|UniProtKB=O60266	Adenylate cyclase type 3	IDA	2491850	PubMed	PTHR11920:SF291	ADENYLATE CYCLASE TYPE 3
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	IDA	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=1351343|UniProtKB=Q5NCH9	Metabotropic glutamate receptor 6	ISS	9407094	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00010	B cell activation	P00375	Calmodulin	ANOGA|EnsemblGenome=AGAP010957|UniProtKB=Q7QGY7	AGAP010957-PA (Fragment)	ISS	3885394	PubMed	PTHR23050:SF245	AT16150P-RELATED
P06664	Gonadotropin-releasing hormone receptor pathway	P06844	SRC	MOUSE|MGI=MGI=98397|UniProtKB=P05480	Neuronal proto-oncogene tyrosine-protein kinase Src	RCA	11078745	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00048	PI3 kinase pathway	P01188	Gbetagamma	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00049	Parkinson disease	P01219	SAPK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	DROME|FlyBase=FBgn0022724|UniProtKB=Q9VWY6	Transcription initiation factor TFIID subunit 8	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	SULSO|EnsemblGenome=SSO1268|UniProtKB=Q97YQ6	Glutamine-fructose-6-phosphate transaminase (Isomerizing) (GlmS-2)	ISS			PTHR10937:SF0	GH12731P-RELATED
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00036	Interleukin signaling pathway	P00964	p90RSK	MONDO|Ensembl=ENSMODG00000006241|UniProtKB=F7FRY0	Ribosomal protein S6 kinase	ISS	1922062	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00047	PDGF signaling pathway	P01153	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02761	Pantothenate biosynthesis	P03066	Aspartate decarboxylase	LEPIN|EnsemblGenome=LA_1729|UniProtKB=Q8CVE9	Aspartate 1-decarboxylase	ISS			PTHR21012:SF0	ASPARTATE 1-DECARBOXYLASE
P00025	Hedgehog signaling pathway	P00682	PKA	STRPU|EnsemblGenome=SPU_018419|UniProtKB=W4YRI6	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=13829|UniProtKB=Q9GZT5	Protein Wnt-10a	IDA	11266476	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT2G43790|UniProtKB=Q39026	Mitogen-activated protein kinase 6	ISS	10851062	PubMed	PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P00005	Angiogenesis	P00193	SOS-1	DICDI|dictyBase=DDB_G0269222|UniProtKB=Q8IS21	Ras guanine nucleotide exchange factor B	ISS			PTHR23113:SF163	RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR B
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	CANLF|Ensembl=ENSCAFG00000023265|UniProtKB=F1PK01	Uncharacterized protein	ISS	11034345	PubMed	PTHR11647:SF58	DIHYDROPYRIMIDINASE-RELATED PROTEIN 5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	CHICK|Gene=CHRNA7|UniProtKB=P22770	Neuronal acetylcholine receptor subunit alpha-7	ISS	11404397	PubMed	PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P00010	B cell activation	P00385	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	15470041	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	RAT|RGD=1310557|UniProtKB=F1LNW1	Protein Rbpj	ISS	8406481	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000003236|UniProtKB=F7DNS6	Uncharacterized protein	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P02753	Methionine biosynthesis	P03026	O-Succinyl homoserine lyase	ARATH|TAIR=AT1G33320|UniProtKB=Q9C876	Probable cystathionine gamma-synthase 2	ISS			PTHR43379:SF1	CYSTATHIONINE GAMMA-SYNTHASE 1, CHLOROPLASTIC-RELATED
P00049	Parkinson disease	P01238	14-3-3	CANLF|Ensembl=ENSCAFG00000013549|UniProtKB=E2QVP6	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	ARATH|TAIR=AT3G22320|UniProtKB=O81098	DNA-directed RNA polymerases II and IV subunit 5A	ISS	11313498	gi	PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P00010	B cell activation	P00385	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	10802295	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00021	FGF signaling pathway	P00648	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00006	Apoptosis signaling pathway	P00260	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01185	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00018	EGF receptor signaling pathway	P00565	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	IGI	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00029	Huntington disease	P00807	Actin	ORYSJ|EnsemblGenome=OS05G0438800|UniProtKB=Q75HX0	Actin	IDA	10974003	PubMed	PTHR11937:SF248	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00924	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	YEAST|SGD=S000003272|UniProtKB=P14681	Mitogen-activated protein kinase KSS1	ISS	10514528	PubMed	PTHR24055:SF338	MITOGEN-ACTIVATED PROTEIN KINASE KSS1
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	18021322	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00053	T cell activation	P01311	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02723	Adenine and hypoxanthine salvage pathway	P02807	Deoxyadenosine deaminase	ANOGA|EnsemblGenome=AGAP005158|UniProtKB=Q7Q9M2	AGAP005158-PA	ISS			PTHR11409:SF42	ADENOSINE DEAMINASE-LIKE PROTEIN
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	BOVIN|Ensembl=ENSBTAG00000019832|UniProtKB=G3MZV8	TGF-beta receptor type-2	ISS	9759503	PubMed	PTHR23255:SF55	TGF-BETA RECEPTOR TYPE-2
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=14270|UniProtKB=Q8TAB3	Protocadherin-19	ISS	8120095	PubMed	PTHR24028:SF40	PROTOCADHERIN-19
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ANOGA|EnsemblGenome=AGAP001676|UniProtKB=Q7PXZ8	AGAP001676-PA	IDA	14684598	PubMed	PTHR11937:SF368	ACTIN, INDIRECT FLIGHT MUSCLE
P00019	Endothelin signaling pathway	P00570	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9441|UniProtKB=P51817	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04393	Ras Pathway	P04574	PLD	RAT|RGD=3349|UniProtKB=P70496	Phospholipase D1	ISS	10497874	PubMed	PTHR18896:SF57	PHOSPHOLIPASE D1
P00019	Endothelin signaling pathway	P00568	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00025	Hedgehog signaling pathway	P00682	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00924	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02781	Threonine biosynthesis	P03189	Aspartate kinase	LEPIN|EnsemblGenome=LA_0693|UniProtKB=Q8F865	Aspartokinase	ISS			PTHR21499:SF3	ASPARTOKINASE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00010	B cell activation	P00376	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=88399|UniProtKB=P32211	Muscarinic acetylcholine receptor M4	IDA	11166329	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P04393	Ras Pathway	P04570	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	87218499	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	MACMU|Ensembl=ENSMMUG00000010173|UniProtKB=F7AGU8	Presenilin	ISS	12736250	PubMed	PTHR10202:SF18	PRESENILIN-1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MOUSE|MGI=MGI=1339967|UniProtKB=B1AR69	Protein Myh13	IEP	89264452	PubMed	PTHR13140:SF504	MYOSIN-13
P00049	Parkinson disease	P01238	14-3-3	ORNAN|Ensembl=ENSOANG00000007305|UniProtKB=F6XW91	Uncharacterized protein	ISS	12861023	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04393	Ras Pathway	P04557	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	IDA	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	DANRE|ZFIN=ZDB-GENE-020419-28|UniProtKB=F1Q9U6	Adenylosuccinate synthetase	ISS			PTHR11846:SF3	ADENYLOSUCCINATE SYNTHETASE
P00034	Integrin signalling pathway	P00907	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05918	p38 MAPK pathway	P06020	p38delta	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	RCA	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00021	FGF signaling pathway	P00627	ERK1-2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00807	Actin	XENTR|Xenbase=XB-GENE-493937|UniProtKB=Q5M8T9	Actin, alpha 2, smooth muscle, aorta	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00049	Parkinson disease	P01211	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00012	Cadherin signaling pathway	P00477	GSK3beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	P00564	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=4404|UniProtKB=P59768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00034	Integrin signalling pathway	P00927	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	IGI	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00006	Apoptosis signaling pathway	P00260	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	FUSNN|EnsemblGenome=FN0422|UniProtKB=Q8RG86	Carbamoyl-phosphate synthase large chain	ISS			PTHR11405:SF5	CAD PROTEIN
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04413	K+ channel	PANTR|Ensembl=ENSPTRG00000020614|UniProtKB=H2QWR7	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00029	Huntington disease	P00805	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01369	MKK1	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IGI	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00168	E-cadherin intracellular fragment	XENTR|Xenbase=XB-GENE-482277|UniProtKB=F6QAX3	Uncharacterized protein	ISS	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P00047	PDGF signaling pathway	P01161	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00780	Microtubule	LEIMA|EnsemblGenome=LmjF.08.1230|UniProtKB=Q4QI42	Beta tubulin	IDA	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00018	EGF receptor signaling pathway	P00556	PLCgamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05918	p38 MAPK pathway	P06020	p38delta	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	RCA	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00477	GSK3beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04393	Ras Pathway	P04552	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00036	Interleukin signaling pathway	P00994	FKHRL1	MACMU|Ensembl=ENSMMUG00000020369|UniProtKB=F6UMX8	Uncharacterized protein	ISS	10102273	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00046	Oxidative stress response	P01129	JNK1/2	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00036	Interleukin signaling pathway	P00973	PKB	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00060	Ubiquitin proteasome pathway	P01491	E2	TAKRU|Ensembl=ENSTRUG00000010964|UniProtKB=H2TSM2	Uncharacterized protein	ISS			PTHR43898:SF4	UBIQUITIN-CONJUGATING ENZYME E2 A
P00021	FGF signaling pathway	P00629	PP2A	XENTR|Xenbase=XB-GENE-957526|UniProtKB=K9J7P6	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	RAT|RGD=69319|UniProtKB=P54313	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01219	SAPK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	NAS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01429	Axin	PANTR|Ensembl=ENSPTRG00000007537|UniProtKB=H2R1H5	Uncharacterized protein	ISS	9554852	PubMed	PTHR10845:SF11	AXIN-1
P00057	Wnt signaling pathway	P01428	Frizzled	BOVIN|Ensembl=ENSBTAG00000007047|UniProtKB=A3KMX5	FZD10 protein	ISS	11212302	PubMed	PTHR11309:SF86	FRIZZLED-10
P00020	FAS signaling pathway	P00616	Nuclear Lamin	DROME|FlyBase=FBgn0002525|UniProtKB=P08928	Lamin Dm0	TAS	11165516	PubMed	PTHR23239:SF234	LAMIN DM0-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01390	TFIIA complex	YEAST|SGD=S000001541|UniProtKB=P32774	Transcription initiation factor IIA subunit 2	ISS			PTHR10966:SF0	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	DROME|FlyBase=FBgn0015024|UniProtKB=P54367	Casein kinase I isoform alpha	IDA	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	DANRE|ZFIN=ZDB-GENE-010705-1|UniProtKB=Q90Z40	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00018	EGF receptor signaling pathway	P00564	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	20010089	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00029	Huntington disease	P00777	CBP	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00840	GPRK	MOUSE|MGI=MGI=87940|UniProtKB=Q99MK8	Beta-adrenergic receptor kinase 1	IDA	10852916	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00125	Ire-1 C-terminal fragment	RAT|RGD=1308743|UniProtKB=D3ZTI7	Endoplasmic reticulum (ER) to nucleus signalling 2 (Predicted)	ISS	10619423	PubMed	PTHR13954:SF15	SERINE/THREONINE-PROTEIN KINASE/ENDORIBONUCLEASE IRE2
P02775	Salvage pyrimidine ribonucleotides	P03155	Cytosine deaminase	MYCTU|EnsemblGenome=LH57_20445|UniProtKB=O69719	tRNA-specific adenosine deaminase	ISS			PTHR11079:SF149	TRNA-SPECIFIC ADENOSINE DEAMINASE
P04393	Ras Pathway	P04567	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	HUMAN|HGNC=11534|UniProtKB=Q15572	TATA box-binding protein-associated factor RNA polymerase I subunit C	ISS	604905	OMIM	PTHR15319:SF1	TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT C
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	TAKRU|Ensembl=ENSTRUG00000015213|UniProtKB=H2UPJ1	Uncharacterized protein	ISS	20112749	PubMed	PTHR18966:SF356	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000016097|UniProtKB=E1B9S9	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00012	Cadherin signaling pathway	P00462	Casein kinase II	BOVIN|Gene=CSNK2A1|UniProtKB=P68399	Casein kinase II subunit alpha	ISS	10617630	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	MONDO|Ensembl=ENSMODG00000012981|UniProtKB=F7CS91	Uncharacterized protein	ISS	10556059	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P05731	GABA-B receptor II signaling	P05754	Ggamma	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00054	Toll receptor signaling pathway	P01339	TLR4	BOVIN|Gene=TLR4|UniProtKB=Q9GL65	Toll-like receptor 4	ISS			PTHR44568:SF1	TOLL-LIKE RECEPTOR 4
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	ORNAN|Ensembl=ENSOANG00000002061|UniProtKB=F7ANC6	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CAEBR|Gene=CBG12389|UniProtKB=A8XFB4	Protein CBR-UNC-29	ISS	22213672	PubMed	PTHR18945:SF471	ACETYLCHOLINE RECEPTOR SUBUNIT BETA-TYPE UNC-29
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P05912	Dopamine receptor mediated signaling pathway	P05963	MAO	XENTR|Xenbase=XB-GENE-5749883|UniProtKB=F6V922	Uncharacterized protein (Fragment)	ISS	8602220	PubMed	PTHR43563:SF2	AMINE OXIDASE  FLAVIN-CONTAINING
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	12846562	PubMed	PTHR10202:SF13	PRESENILIN-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	IDA	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00012	Cadherin signaling pathway	P00463	betacatenin	DANRE|ZFIN=ZDB-GENE-040426-2575|UniProtKB=E7FC99	Uncharacterized protein	ISS	7906389	PubMed	PTHR23315:SF68	SUBFAMILY NOT NAMED
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04393	Ras Pathway	P04570	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01411	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00015	Circadian clock system	P00501	Clock	HUMAN|HGNC=2082|UniProtKB=O15516	Circadian locomoter output cycles protein kaput	IDA	10198158	PubMed	PTHR23042:SF2	CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT
P00021	FGF signaling pathway	P00638	PLCgamma	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04395	Vasopressin synthesis	P04594	Neurophysin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00006	Apoptosis signaling pathway	P00260	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	BOVIN|Ensembl=ENSBTAG00000018204|UniProtKB=Q9BE40	Myosin-1	ISS	89264452	PubMed	PTHR13140:SF484	MYOSIN-1
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	RAT|RGD=1308423|UniProtKB=D3ZY89	Protein Taf8	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IGI	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04395	Vasopressin synthesis	P04596	Endo Peptidase	GLOVI|Gene=BAC91212|UniProtKB=Q7NGA2	Prolyl endopeptidase	IC	9695945	PubMed	PTHR42881:SF2	PROLYL ENDOPEPTIDASE
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	CANLF|Ensembl=ENSCAFG00000016066|UniProtKB=E2R7K2	Uncharacterized protein	ISS	10409711	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P00054	Toll receptor signaling pathway	P01358	ERK1	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01154	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00053	T cell activation	P01324	rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	4757952	gi	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00046	Oxidative stress response	P01121	MKK3/6	CANLF|Ensembl=ENSCAFG00000018530|UniProtKB=F1PXD3	Uncharacterized protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00047	PDGF signaling pathway	P01162	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	TAS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05915	Opioid proenkephalin pathway	P05994	G-protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00566	ERK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	IGI	94131270	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	ORYSJ|Gene=Os01g0198200|UniProtKB=Q5QMY9	Os01g0198200 protein	IDA	10617630	PubMed	PTHR11909:SF288	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04551	RalGDS	CANLF|Gene=RGL2|UniProtKB=Q5TJE5	Ral guanine nucleotide dissociation stimulator-like 2	IDA	8939933	PubMed	PTHR23113:SF213	RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 2
P00049	Parkinson disease	P01238	14-3-3	HUMAN|HGNC=10773|UniProtKB=P31947	14-3-3 protein sigma	IDA	10407019	PubMed	PTHR18860:SF14	14-3-3 PROTEIN SIGMA
P00029	Huntington disease	P00787	MAPKK4	MONDO|Ensembl=ENSMODG00000008266|UniProtKB=F6Z879	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P05913	Enkephalin release	P05972	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	2372396	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	RCA	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00049	Parkinson disease	P01211	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01063	CAT	CAEBR|Gene=CBG08305|UniProtKB=A8X694	Protein CBR-CHA-1	ISS	92155737	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BOVIN|Ensembl=ENSBTAG00000013017|UniProtKB=P04696	Guanine nucleotide-binding protein G(t) subunit alpha-2	ISS	12488551	PubMed	PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P00036	Interleukin signaling pathway	P00965	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IC	9603989	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	PANTR|Ensembl=ENSPTRG00000018361|UniProtKB=P60020	5-hydroxytryptamine receptor 1B	ISS	12441358	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000022175|UniProtKB=F6XHY0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8971|UniProtKB=O00443	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00049	Parkinson disease	P01236	Casein kinase II	CIOIN|Ensembl=ENSCING00000009515|UniProtKB=Q8T3S5	Casein kinase 2 alpha subunit	IDA	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01154	Ras	CAEBR|Gene=CBG06092|UniProtKB=A8X0X5	Protein CBR-LET-60	ISS	22022015	PubMed	PTHR24070:SF385	GTPASE HRAS
P00053	T cell activation	P01329	CD45	HUMAN|HGNC=9666|UniProtKB=P08575	Receptor-type tyrosine-protein phosphatase C	IGI	1672451	PubMed	PTHR19134:SF284	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00163	Erb-B4 C-terminal fragment	PANTR|Ensembl=ENSPTRG00000012883|UniProtKB=H2QJC5	Receptor protein-tyrosine kinase	ISS	4884676	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00010	B cell activation	P00383	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	IC	10553940	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	BOVIN|Gene=RGS9|UniProtKB=O46469	Regulator of G-protein signaling 9	IDA	8756726	PubMed	PTHR10845:SF170	REGULATOR OF G-PROTEIN SIGNALING 9
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	IDA	15313841	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	METAC|EnsemblGenome=MA_0587|UniProtKB=Q8TT52	Glutamate--tRNA ligase	ISS			PTHR43097:SF5	GLUTAMATE--TRNA LIGASE, CYTOPLASMIC
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	TAKRU|Ensembl=ENSTRUG00000003520|UniProtKB=H2S791	Uncharacterized protein	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TAKRU|Ensembl=ENSTRUG00000005447|UniProtKB=P68142	Actin, cytoplasmic 1	IC	3487386	PubMed	PTHR11937:SF354	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01415	MAPKAPK2/3	MACMU|Ensembl=ENSMMUG00000023567|UniProtKB=F7HHY8	Uncharacterized protein	ISS	8262198	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	TAKRU|Ensembl=ENSTRUG00000010213|UniProtKB=H2TM14	Uncharacterized protein (Fragment)	ISS	85270494	PubMed	PTHR18945:SF401	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	ISS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00019	Endothelin signaling pathway	P00591	PLCbeta	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00018	EGF receptor signaling pathway	P00557	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	IDA	12169092	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P02746	Heme biosynthesis	P02979	porphobilinogen synthase	BOVIN|Ensembl=ENSBTAG00000000251|UniProtKB=Q58DK5	Delta-aminolevulinic acid dehydratase	ISS			PTHR11458:SF0	DELTA-AMINOLEVULINIC ACID DEHYDRATASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00019	Endothelin signaling pathway	P00587	Raf-1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00019	Endothelin signaling pathway	P00587	Raf-1	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	ISS			PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P04393	Ras Pathway	P04570	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12701063	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	XENTR|Xenbase=XB-GENE-923233|UniProtKB=Q6AZK9	Nucleoside diphosphate kinase	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00059	p53 pathway	G04694	p110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00051	TCA cycle	P01269	alphaketoglutarate Dehydrogenase	BOVIN|Ensembl=ENSBTAG00000006029|UniProtKB=Q148N0	2-oxoglutarate dehydrogenase, mitochondrial	ISS	12477932	PubMed	PTHR23152:SF7	2-OXOGLUTARATE DEHYDROGENASE, MITOCHONDRIAL
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	STRPU|EnsemblGenome=SPU_018419|UniProtKB=W4YRI6	Uncharacterized protein	ISS	97210759	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00558	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00048	PI3 kinase pathway	P01192	p110	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00477	GSK3beta	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	IDA	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00004	Alzheimer disease-presenilin pathway	P00118	E-cadherin	XENTR|Xenbase=XB-GENE-482277|UniProtKB=F6QAX3	Uncharacterized protein	ISS	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	ISS	96320556	PubMed	PTHR10048:SF14	PI-3 KINASE
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00059	p53 pathway	G04694	p110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000017328|UniProtKB=Q5DRF0	Protocadherin alpha-2	ISS	8120095	PubMed	PTHR24028:SF60	PROTOCADHERIN ALPHA-2
P05916	Opioid prodynorphin pathway	P06000	vasopressin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00049	Parkinson disease	P01230	Src kinase	BOVIN|Ensembl=ENSBTAG00000011851|UniProtKB=A0JNB0	Tyrosine-protein kinase Fyn	ISS	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02777	Succinate to proprionate conversion	P03163	Methylmalonyl-CoA decarboxylase	HALSA|EnsemblGenome=VNG_0623G|UniProtKB=Q9HRN1	Propionyl-CoA carboxylase homolog	ISS			PTHR22855:SF13	METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	SCHPO|PomBase=SPAC6G9.11|UniProtKB=Q92356	Synaptobrevin homolog 1	ISS	88248054	PubMed	PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	CANLF|Gene=PSEN1|UniProtKB=Q6RH31	Presenilin-1	ISS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00018	EGF receptor signaling pathway	P00554	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	CANLF|Ensembl=ENSCAFG00000001315|UniProtKB=E2R9S7	Uncharacterized protein	ISS	1904011	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00107	kinesin	CHICK|Ensembl=ENSGALG00000011528|UniProtKB=E1BZD8	Uncharacterized protein	ISS	11740561	PubMed	PTHR19959:SF203	KINESIN LIGHT CHAIN 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P05918	p38 MAPK pathway	P06034	MKK4	MONDO|Ensembl=ENSMODG00000008266|UniProtKB=F6Z879	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CAEEL|WormBase=WBGene00001680|UniProtKB=Q20636	Guanine nucleotide-binding protein subunit beta-2	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	RCA	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00951	Jnk	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	IDA	12040174	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00006	Apoptosis signaling pathway	P00310	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IDA			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00056	VEGF signaling pathway	P01408	Akt/PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00558	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00023	General transcription regulation	P00668	TFIIB	ARATH|TAIR=AT3G09360|UniProtKB=Q0WVQ3	Cyclin/Brf1-like TBP-binding protein	ISS			PTHR11618:SF4	TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02770	Pyridoxal phosphate salvage pathway	P03121	Pyridoxal kinase	MACMU|Ensembl=ENSMMUG00000012300|UniProtKB=F7DLS4	Uncharacterized protein	ISS	9099727	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P00006	Apoptosis signaling pathway	P00274	JNK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	ISS	11007936	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	NAS	4506785	gi	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	MACMU|Ensembl=ENSMMUG00000022009|UniProtKB=F6RBZ7	Cell division control protein 42 homolog isoform 2	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	RAT|RGD=2744|UniProtKB=P31422	Metabotropic glutamate receptor 3	ISS	20012997	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00053	T cell activation	P01312	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00010	B cell activation	P00373	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00018	EGF receptor signaling pathway	P00550	Grb2	HUMAN|HGNC=4562|UniProtKB=Q13588	GRB2-related adapter protein	ISS	11971956	PubMed	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CANLF|Ensembl=ENSCAFG00000004930|UniProtKB=E2RFB5	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04557	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IDA	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	RAT|RGD=2733|UniProtKB=P42260	Glutamate receptor ionotropic, kainate 2	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P05918	p38 MAPK pathway	P06036	MKK3	ORNAN|Ensembl=ENSOANG00000007732|UniProtKB=F6PXH5	Uncharacterized protein (Fragment)	ISS	11971971	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00018	EGF receptor signaling pathway	P00549	EGF	CANLF|Ensembl=ENSCAFG00000005749|UniProtKB=E2R275	Uncharacterized protein	ISS	8488984	gi	PTHR10740:SF4	PROHEPARIN-BINDING EGF-LIKE GROWTH FACTOR
P05916	Opioid prodynorphin pathway	P06002	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00018	EGF receptor signaling pathway	P00547	PP2A	ORYSJ|EnsemblGenome=OS08G0122000|UniProtKB=Q6YX33	Os08g0122000 protein	ISS			PTHR10257:SF17	SUBFAMILY NOT NAMED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P02738	De novo purine biosynthesis	P02907	dADP kinase	METJA|EnsemblGenome=MJ_1265|UniProtKB=Q58661	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	TAS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00009	Axon guidance mediated by netrin	P00366	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	15470041	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	CAEEL|WormBase=WBGene00000913|UniProtKB=G5EE01	DAF-18	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	METJA|EnsemblGenome=MJ_0507|UniProtKB=Q57930	TATA-box-binding protein	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	MACMU|Ensembl=ENSMMUG00000009287|UniProtKB=F7H3T9	Glutamate receptor 1 isoform 1	ISS	12871085	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	ARATH|TAIR=AT1G55970|UniProtKB=Q9LG11	Histone acetyltransferase HAC4	ISS	10664585	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=2683547|UniProtKB=Q4KWH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1	ISS	7822322	PubMed	PTHR10336:SF51	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-1
P00005	Angiogenesis	P00219	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00010	B cell activation	P00379	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MOUSE|MGI=MGI=87902|UniProtKB=P68134	Actin, alpha skeletal muscle	ISS	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PHYIT|EnsemblGenome=PITG_00156|UniProtKB=D0MT13	Beta-tubulin	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00005	Angiogenesis	P00187	beta catenin	ORNAN|Ensembl=ENSOANG00000006811|UniProtKB=F6WBD5	Uncharacterized protein	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00018	EGF receptor signaling pathway	P00545	JNK1-3	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00814	P300	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MOUSE|MGI=MGI=95822|UniProtKB=Q01098	Glutamate receptor ionotropic, NMDA 2C	IC	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00010	B cell activation	P00402	Jnk	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00053	T cell activation	P01319	PAK	MACMU|Ensembl=ENSMMUG00000012033|UniProtKB=F7GWI2	Serine/threonine-protein kinase PAK 2	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P02777	Succinate to proprionate conversion	P03163	Methylmalonyl-CoA decarboxylase	ECOLI|EcoGene=EG12972|UniProtKB=P52045	Methylmalonyl-CoA decarboxylase	RCA			PTHR11941:SF54	ENOYL-COA HYDRATASE, MITOCHONDRIAL
P05913	Enkephalin release	P05977	G-Protein (s)	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	MACMU|Ensembl=ENSMMUG00000022009|UniProtKB=F6RBZ7	Cell division control protein 42 homolog isoform 2	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00057	Wnt signaling pathway	P01438	PP2A	DANRE|ZFIN=ZDB-GENE-040426-877|UniProtKB=F1Q6Z7	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01455	Smad4	MONDO|Ensembl=ENSMODG00000015152|UniProtKB=F7CFQ6	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF36	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5
P00055	Transcription regulation by bZIP transcription factor	P01392	TFIIH complex	HUMAN|HGNC=4658|UniProtKB=Q92759	General transcription factor IIH subunit 4	ISS			PTHR13152:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00010	B cell activation	P00384	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=17999|UniProtKB=Q6P5Z2	Serine/threonine-protein kinase N3	TAS	10644715	PubMed	PTHR24356:SF175	SERINE/THREONINE-PROTEIN KINASE N3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_56687|UniProtKB=C3YC50	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00053	T cell activation	P01319	PAK	CANLF|Ensembl=ENSCAFG00000004956|UniProtKB=E2REH3	Uncharacterized protein	ISS	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00047	PDGF signaling pathway	P01174	Rho	RAT|RGD=1359304|UniProtKB=Q6AYC5	Rho GTPase-activating protein 15	ISS	8288572	PubMed	PTHR23181:SF5	RHO GTPASE-ACTIVATING PROTEIN 15
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	CANLF|Ensembl=ENSCAFG00000017679|UniProtKB=E2RMD8	Ribosomal protein S6 kinase	ISS	15116068	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	15210700	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00384	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00029	Huntington disease	P00770	N-CoR	XENTR|Xenbase=XB-GENE-483288|UniProtKB=Q4KKX4	Nuclear receptor corepressor 1	ISS	10441327	PubMed	PTHR13992:SF5	NUCLEAR RECEPTOR COREPRESSOR 1
P06959	CCKR signaling map	G07282	CALCA	HUMAN|HGNC=1437|UniProtKB=P01258	Calcitonin	RCA	20671197	PubMed	PTHR10505:SF14	CALCITONIN
P00056	VEGF signaling pathway	P01417	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P02726	Aminobutyrate degradation	P02825	4-aminobutyrate aminotransferase	CANLF|Ensembl=ENSCAFG00000019030|UniProtKB=E2R776	Uncharacterized protein	ISS	2496985	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01322	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	XENTR|Xenbase=XB-GENE-491571|UniProtKB=F6WW07	Uncharacterized protein (Fragment)	ISS	17943202	gi	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00048	PI3 kinase pathway	P01177	P110ACT	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00020	FAS signaling pathway	P00615	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=98329|UniProtKB=P30935	Somatostatin receptor type 3	IDA	12181435	PubMed	PTHR24229:SF42	SOMATOSTATIN RECEPTOR TYPE 3
P05915	Opioid proenkephalin pathway	P05994	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00053	T cell activation	P01332	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	MOUSE|MGI=MGI=87887|UniProtKB=Q8R4G9	Neuronal acetylcholine receptor subunit alpha-3	ISS	18005395	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	BACSU|EnsemblGenome=BSU30550|UniProtKB=P54419	S-adenosylmethionine synthase	ISS			PTHR11964:SF1	S-ADENOSYLMETHIONINE SYNTHASE
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	MONDO|Ensembl=ENSMODG00000015761|UniProtKB=F6ZT50	Uncharacterized protein	ISS	11034345	PubMed	PTHR11647:SF58	DIHYDROPYRIMIDINASE-RELATED PROTEIN 5
P02746	Heme biosynthesis	P02975	Uroporphyrinogen decarboxylase	ARATH|TAIR=AT2G40490|UniProtKB=O22886	Uroporphyrinogen decarboxylase 2, chloroplastic	ISS			PTHR21091:SF133	UROPORPHYRINOGEN DECARBOXYLASE 2, CHLOROPLASTIC
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00036	Interleukin signaling pathway	P00996	STAT	MOUSE|MGI=MGI=103036|UniProtKB=P42230	Signal transducer and activator of transcription 5A	IC	14662325	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00005	Angiogenesis	P00189	Fzd	MOUSE|MGI=MGI=1888513|UniProtKB=Q9JIP6	Frizzled-2	ISS	8717036	PubMed	PTHR11309:SF34	FRIZZLED-2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	IC	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ARATH|TAIR=AT2G42880|UniProtKB=Q9SJG9	Mitogen-activated protein kinase 20	IDA	18406088	gi	PTHR24055:SF158	MITOGEN-ACTIVATED PROTEIN KINASE 20
P00034	Integrin signalling pathway	P00916	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IPI	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P02738	De novo purine biosynthesis	P02905	Amidophosphoribosyl transferase	RAT|RGD=620237|UniProtKB=P35433	Amidophosphoribosyltransferase	ISS			PTHR11907:SF18	AMIDOPHOSPHORIBOSYLTRANSFERASE
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12912997	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00025	Hedgehog signaling pathway	P00682	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01421	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	RCA			PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00053	T cell activation	P01322	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000002297|UniProtKB=F1N167	Uncharacterized protein	ISS			PTHR11824:SF7	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	HUMAN|HGNC=6026|UniProtKB=P25024	C-X-C chemokine receptor type 1	IC	1840701	PubMed	PTHR10489:SF916	C-X-C CHEMOKINE RECEPTOR TYPE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00570	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00859	NFkappaB	MACMU|Ensembl=ENSMMUG00000014153|UniProtKB=F7BV28	Uncharacterized protein	RCA			PTHR24169:SF18	TRANSCRIPTION FACTOR RELB
P00001	Adrenaline and noradrenaline biosynthesis	P00070	VAT2	HUMAN|HGNC=10935|UniProtKB=Q05940	Synaptic vesicular amine transporter	IC	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	PANTR|Ensembl=ENSPTRG00000017441|UniProtKB=H2QRU7	Glutamate receptor, ionotropic, AMPA 1	ISS	12871085	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PHYPA|Gene=PHYPADRAFT_226658|UniProtKB=A9TYG3	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00018	EGF receptor signaling pathway	P00546	GAP	HUMAN|HGNC=9871|UniProtKB=P20936	Ras GTPase-activating protein 1	IGI	11847220	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	PANTR|Gene=HTR1E|UniProtKB=Q9N2B6	5-hydroxytryptamine receptor 1E (Fragment)	ISS			PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	RAT|RGD=3139|UniProtKB=Q29RW1	Myosin-4	ISS	89264452	PubMed	PTHR13140:SF657	MYOSIN-4
P04393	Ras Pathway	P04578	Rho	HUMAN|HGNC=669|UniProtKB=P08134	Rho-related GTP-binding protein RhoC	IDA	14871999	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	YEAST|SGD=S000005854|UniProtKB=P33328	Synaptobrevin homolog 2	IC			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00907	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01227	20S proteasome	BOVIN|Ensembl=ENSBTAG00000005127|UniProtKB=Q3ZBG0	Proteasome subunit alpha type-7	ISS	12859888	PubMed	PTHR11599:SF40	PROTEASOME SUBUNIT ALPHA TYPE-7
P00029	Huntington disease	P00775	Rac	DROME|FlyBase=FBgn0039532|UniProtKB=Q7JWS8	AT17867p	ISS			PTHR24072:SF157	AT17867P
P05730	Endogenous cannabinoid signaling	P05743	CB1	MACMU|Gene=CNR1|UniProtKB=Q71SP5	Cannabinoid receptor 1	ISS	9888857	PubMed	PTHR22750:SF47	CANNABINOID RECEPTOR 1
P00021	FGF signaling pathway	P00639	Shc	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	ISS	8264585	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	BOVIN|Ensembl=ENSBTAG00000043971|UniProtKB=E1BPT8	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00057	Wnt signaling pathway	P01440	Cadherin	CANLF|Ensembl=ENSCAFG00000018973|UniProtKB=E2R971	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF99	CADHERIN-9
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00005	Angiogenesis	P00219	PKC	CANLF|Ensembl=ENSCAFG00000004256|UniProtKB=E2RR18	Serine/threonine-protein kinase	ISS	11062248	PubMed	PTHR22968:SF12	SERINE/THREONINE-PROTEIN KINASE D2
P02746	Heme biosynthesis	P02979	porphobilinogen synthase	BACSU|EnsemblGenome=BSU28130|UniProtKB=P30950	Delta-aminolevulinic acid dehydratase	ISS			PTHR11458:SF0	DELTA-AMINOLEVULINIC ACID DEHYDRATASE
P00015	Circadian clock system	P00505	Cry	RAT|RGD=620935|UniProtKB=Q923I8	Cryptochrome-2	IDA	10428031	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00018	EGF receptor signaling pathway	P00546	GAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	IDA	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01202	p85	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	HUMAN|HGNC=23366|UniProtKB=Q9BPX5	Actin-related protein 2/3 complex subunit 5-like protein	ISS	12473693	PubMed	PTHR12644:SF2	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5-LIKE PROTEIN
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05915	Opioid proenkephalin pathway	P05994	G-protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00036	Interleukin signaling pathway	P00977	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00047	PDGF signaling pathway	P01154	Ras	DICDI|dictyBase=DDB_G0292998|UniProtKB=P32252	Ras-like protein rasB	ISS	93205383	PubMed	PTHR24070:SF206	RAS-LIKE PROTEIN RASB
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	HUMAN|HGNC=7882|UniProtKB=Q04721	Neurogenic locus notch homolog protein 2	IDA	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00021	FGF signaling pathway	P00633	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00006	Apoptosis signaling pathway	P00314	MKK3	BOVIN|Ensembl=ENSBTAG00000010576|UniProtKB=A4IFH7	MAP2K3 protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	PANTR|Ensembl=ENSPTRG00000021023|UniProtKB=G2HJM2	Aldehyde dehydrogenase 1 family, member A1	ISS			PTHR11699:SF140	RETINAL DEHYDROGENASE 1
P02779	Thiamin biosynthesis	P03170	Hydroxymethylpyrimidine phosphate kinase	GLOVI|Gene=BAC89452|UniProtKB=Q7NKG7	Phosphomethylpyrimidine kinase	ISS			PTHR20858:SF17	HYDROXYMETHYLPYRIMIDINE/PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000007445|UniProtKB=F6SWI4	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	IC	8457205	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00005	Angiogenesis	P00238	Ras	XENTR|Xenbase=XB-GENE-494548|UniProtKB=F7EC26	Uncharacterized protein	ISS	10825661	PubMed	PTHR24070:SF186	GTPASE KRAS
P06213	DPP signaling pathway	P06283	TLD	DROME|FlyBase=FBgn0003719|UniProtKB=P25723	Dorsal-ventral patterning protein tolloid	IDA	12925593	PubMed	PTHR43978:SF2	DORSAL-VENTRAL PATTERNING PROTEIN TOLLOID-RELATED
P00050	Plasminogen activating cascade	P01262	pro-uPA	MOUSE|MGI=MGI=97611|UniProtKB=P06869	Urokinase-type plasminogen activator	IGI	12376355	PubMed	PTHR24264:SF38	UROKINASE-TYPE PLASMINOGEN ACTIVATOR
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IDA	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00005	Angiogenesis	P00203	Erk	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01307	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00046	Oxidative stress response	P01131	MKP5	MONDO|Ensembl=ENSMODG00000011736|UniProtKB=F7DFP1	Dual specificity protein phosphatase	ISS			PTHR10159:SF305	DUAL SPECIFICITY PROTEIN PHOSPHATASE 7
P00051	TCA cycle	P01273	Succinate Dehydrogenase	SCHPO|PomBase=SPCC330.12c|UniProtKB=O74882	Succinate dehydrogenase cytochrome B subunit, mitochondrial	ISS	21848401	PubMed	PTHR10978:SF5	SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL
P00057	Wnt signaling pathway	P01437	TCF	MOUSE|MGI=MGI=96770|UniProtKB=P27782	Lymphoid enhancer-binding factor 1	IDA	9039917	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P05912	Dopamine receptor mediated signaling pathway	P05950	DARPP-32	PANTR|Ensembl=ENSPTRG00000009095|UniProtKB=H2QCU6	Uncharacterized protein	ISS	3339428	PubMed	PTHR15417:SF2	PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 1B
P00046	Oxidative stress response	P01126	ATF2	CANLF|Ensembl=ENSCAFG00000013332|UniProtKB=F1PCQ4	Uncharacterized protein	ISS	10664585	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00029	Huntington disease	P00778	NMDA receptor	MACMU|Ensembl=ENSMMUG00000016675|UniProtKB=F6VTB5	Uncharacterized protein	ISS	11554554	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P05912	Dopamine receptor mediated signaling pathway	P05963	MAO	HUMAN|HGNC=6834|UniProtKB=P27338	Amine oxidase [flavin-containing] B	ISS	8602220	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	DICDI|dictyBase=DDB_G0293434|UniProtKB=P15064	Ras-like protein rasG	ISS	7997267	PubMed	PTHR24070:SF282	RAS GTPASE-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	IC	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00009	Axon guidance mediated by netrin	P00357	Netrin	HUMAN|HGNC=8029|UniProtKB=O95631	Netrin-1	ISS	11356879	PubMed	PTHR10574:SF365	NETRIN-1
P02724	Alanine biosynthesis	P02815	Branched chain amino acid aminotransferase	ARATH|TAIR=AT1G50090|UniProtKB=Q9LPM8	Putative branched-chain-amino-acid aminotransferase 7	ISS			PTHR42825:SF4	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 6-RELATED
P02788	Xanthine and guanine salvage pathway	P03249	Guanine deaminase	PANTR|Ensembl=ENSPTRG00000021020|UniProtKB=H2R3N5	Uncharacterized protein	ISS	11962625	PubMed	PTHR11271:SF6	GUANINE DEAMINASE
P06587	Nicotine pharmacodynamics pathway	P06590	GNG	BOVIN|Ensembl=ENSBTAG00000003043|UniProtKB=P63212	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00049	Parkinson disease	P01221	Torsin A	CAEEL|WormBase=WBGene00006598|UniProtKB=Q9XXG5	TORsin related	IDA	12421356	PubMed	PTHR10760:SF2	TORSIN-LIKE PROTEIN
P00018	EGF receptor signaling pathway	P00558	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=2683547|UniProtKB=Q4KWH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1	ISS	15611108	PubMed	PTHR10336:SF51	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	CHICK|Ensembl=ENSGALG00000007039|UniProtKB=F1NG99	Tyrosine-protein kinase receptor	ISS	11182407	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	THEMA|EnsemblGenome=TM_0846|UniProtKB=Q9WZV0	Cytidine/deoxycytidine deaminase	ISS			PTHR11644:SF2	CYTIDINE DEAMINASE
P00034	Integrin signalling pathway	P00907	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01160	IP3 receptor	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	ANOGA|EnsemblGenome=AGAP002578|UniProtKB=F5HKU8	AGAP002578-PB	ISS	14507926	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=107469|UniProtKB=Q8K3R3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	12860966	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00010	B cell activation	P00384	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IDA	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IGI	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00830	Lipoxygenase	RAT|RGD=1311159|UniProtKB=F1LQ70	Arachidonate 12-lipoxygenase, 12S-type	ISS	12432925	PubMed	PTHR11771:SF4	ARACHIDONATE 12-LIPOXYGENASE, 12S-TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	HUMAN|HGNC=19392|UniProtKB=Q8WXH5	Suppressor of cytokine signaling 4	TAS	15032587	PubMed	PTHR44282:SF2	SUPPRESSOR OF CYTOKINE SIGNALING 4
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	BOVIN|Ensembl=ENSBTAG00000005345|UniProtKB=Q3T035	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00021	FGF signaling pathway	P00629	PP2A	CAEEL|WormBase=WBGene00007554|UniProtKB=A9UJN4	Protein Phosphatase 2A (Two A) Regulatory subunit	ISS	10092233	PubMed	PTHR10257:SF3	PP2A-B', ISOFORM B
P02721	ATP synthesis	P02798	Cyt C	XENTR|Xenbase=XB-GENE-971588|UniProtKB=Q6PBF4	Cytochrome c, testis-specific	ISS	4364857	PubMed	PTHR11961:SF12	CYTOCHROME C
P00053	T cell activation	P01322	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CANLF|Ensembl=ENSCAFG00000019807|UniProtKB=F2Z4P1	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00029	Huntington disease	P00786	ARF	DAPPU|EnsemblGenome=DAPPUDRAFT_300544|UniProtKB=E9HDF7	Putative uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF308	ADP-RIBOSYLATION FACTOR 5
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	RAT|RGD=61801|UniProtKB=P30994	5-hydroxytryptamine receptor 2B	ISS	12181435	PubMed	PTHR24247:SF31	5-HYDROXYTRYPTAMINE RECEPTOR 2B
P00021	FGF signaling pathway	P00625	MKK3,6	MACMU|Ensembl=ENSMMUG00000010904|UniProtKB=F7GLY5	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00012	Cadherin signaling pathway	P00474	Wnt	DANRE|ZFIN=ZDB-GENE-081006-1|UniProtKB=F1Q9W3	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00034	Integrin signalling pathway	P00916	Ras	DICDI|dictyBase=DDB_G0292998|UniProtKB=P32252	Ras-like protein rasB	IPI	7997267	PubMed	PTHR24070:SF206	RAS-LIKE PROTEIN RASB
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04375	5HT3 type receptor mediated signaling pathway	P04425	K+ channel	RAT|RGD=61997|UniProtKB=O54912	Potassium channel subfamily K member 3	ISS	15282272	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	XENTR|Ensembl=ENSXETG00000030140|UniProtKB=F7EP58	Uncharacterized protein (Fragment)	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	BOVIN|Ensembl=ENSBTAG00000014828|UniProtKB=F1N1E0	Uncharacterized protein	ISS	14624853	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P05730	Endogenous cannabinoid signaling	P05751	Galpha	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	9395335	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PRIPA|Gene=PPA21757|UniProtKB=H3FHL0	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00010	B cell activation	P00384	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00182	p38MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00046	Oxidative stress response	P01137	MNK1/2	XENTR|Xenbase=XB-GENE-979969|UniProtKB=Q66JF3	MAP kinase-interacting serine/threonine-protein kinase 1	ISS			PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PHANO|EnsemblGenome=SNOG_01139|UniProtKB=H2KNE6	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02728	Arginine biosynthesis	P02840	Argininosuccinate synthase	DROME|FlyBase=FBgn0026565|UniProtKB=O97069	Argininosuccinate synthase	ISS			PTHR11587:SF2	ARGININOSUCCINATE SYNTHASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00021	FGF signaling pathway	P00629	PP2A	CHICK|Ensembl=ENSGALG00000010273|UniProtKB=P48463	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00172	BACE-1	PANTR|Ensembl=ENSPTRG00000004324|UniProtKB=H2Q4U8	Beta-site APP-cleaving enzyme 1	ISS	10531052	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04409	5HT transporter	MOUSE|MGI=MGI=96285|UniProtKB=Q60857	Sodium-dependent serotonin transporter	IEA	7681602	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P00057	Wnt signaling pathway	P01457	GBeta	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04375	5HT3 type receptor mediated signaling pathway	P04425	K+ channel	BOVIN|Ensembl=ENSBTAG00000018193|UniProtKB=E1BHX8	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04395	Vasopressin synthesis	P04597	Signal Peptide	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00047	PDGF signaling pathway	P01173	STAT	BOVIN|Gene=STAT3|UniProtKB=P61635	Signal transducer and activator of transcription 3	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00030	Hypoxia response via HIF activation	P00819	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	IPI	10799299	PubMed	PTHR10048:SF14	PI-3 KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01093	AChE	CAEEL|WormBase=WBGene00000035|UniProtKB=P38433	Acetylcholinesterase 1	IC			PTHR43918:SF3	ACETYLCHOLINESTERASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000001187|UniProtKB=F6R8N9	Mitogen-activated protein kinase	ISS	11875070	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00045	Notch signaling pathway	P01103	Next	BOVIN|Ensembl=ENSBTAG00000007909|UniProtKB=F1MPE9	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00047	PDGF signaling pathway	P01173	STAT	BOVIN|Gene=STAT3|UniProtKB=P61635	Signal transducer and activator of transcription 3	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00018	EGF receptor signaling pathway	P00565	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_127488|UniProtKB=C3XYC7	Putative uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MACMU|Ensembl=ENSMMUG00000001325|UniProtKB=F7BGU5	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	BOVIN|Ensembl=ENSBTAG00000021494|UniProtKB=F1N5R9	Homeobox protein engrailed-like	ISS	12356903	PubMed	PTHR24341:SF4	HOMEOBOX PROTEIN ENGRAILED-1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DANRE|ZFIN=ZDB-GENE-040426-2695|UniProtKB=Q7ZUZ2	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF195	BETA-CENTRACTIN
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00048	PI3 kinase pathway	P01177	P110ACT	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01242	Casein kinase I	BOVIN|Ensembl=ENSBTAG00000005326|UniProtKB=P67827	Casein kinase I isoform alpha	ISS	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_56698|UniProtKB=C3XYC3	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P05730	Endogenous cannabinoid signaling	P05746	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Gene=OPRM1|UniProtKB=Q5IS39	Mu-type opioid receptor	ISS	12093103	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	DICDI|dictyBase=DDB_G0292736|UniProtKB=Q02158	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	TAS			PTHR10336:SF105	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE
P00019	Endothelin signaling pathway	P00566	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01423	p38MAPK	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04393	Ras Pathway	P04556	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00970	Interleukin	MOUSE|MGI=MGI=96557|UniProtKB=P04401	Interleukin-5	IC	11196714	PubMed	PTHR45421:SF1	INTERLEUKIN-5
P00021	FGF signaling pathway	P00634	MEKK1-5	MOUSE|MGI=MGI=1855691|UniProtKB=Q9WTR2	Mitogen-activated protein kinase kinase kinase 6	ISS			PTHR11584:SF391	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 6
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00875	GEF	MOUSE|MGI=MGI=98923|UniProtKB=P27870	Proto-oncogene vav	IDA	14623913	PubMed	PTHR22826:SF112	PROTO-ONCOGENE VAV
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	BATDJ|Gene=BATDEDRAFT_37213|UniProtKB=F4P7H8	Alpha-Beta tubulin	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00059	p53 pathway	P01486	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00475	Frizzled	PANTR|Ensembl=ENSPTRG00000005632|UniProtKB=H2Q772	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF86	FRIZZLED-10
P00022	General transcription by RNA polymerase I	P00652	RNA Polymerase I  Complex	MACMU|Ensembl=ENSMMUG00000002991|UniProtKB=F7GVV6	RNA polymerase I-specific transcription initiation factor RRN3	ISS			PTHR12790:SF0	RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN3-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	ANOGA|EnsemblGenome=AGAP001478|UniProtKB=Q7PXM3	AGAP001478-PA	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00018	EGF receptor signaling pathway	P00544	c-Cbl	CANLF|Ensembl=ENSCAFG00000009793|UniProtKB=E2RM91	Uncharacterized protein	ISS	95303504	PubMed	PTHR23007:SF3	E3 UBIQUITIN-PROTEIN LIGASE CBL-B
P00053	T cell activation	P01324	rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12874273	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00016	Cytoskeletal regulation by Rho GTPase	P00507	Rho	EMENI|EnsemblGenome=CADANIAG00003322|UniProtKB=Q9C3Y4	GTP-binding protein rhoA	ISS	11973360	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=109356|UniProtKB=O09044	Synaptosomal-associated protein 23	IC	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	IC	10477300	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	CANLF|Ensembl=ENSCAFG00000004381|UniProtKB=J9JH96	Uncharacterized protein	ISS	14614461	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MOUSE|MGI=MGI=1888513|UniProtKB=Q9JIP6	Frizzled-2	TAS	8717036	PubMed	PTHR11309:SF34	FRIZZLED-2
P00052	TGF-beta signaling pathway	P01289	I-Smads	PANTR|Ensembl=ENSPTRG00000010010|UniProtKB=H2QEI2	Mothers against decapentaplegic homolog	ISS	9335505	PubMed	PTHR13703:SF27	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 7
P00036	Interleukin signaling pathway	P00996	STAT	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01192	p110	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00029	Huntington disease	P00786	ARF	CHICK|Ensembl=ENSGALG00000011651|UniProtKB=E1BVB0	Uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	TAS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00053	T cell activation	P01300	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00049	Parkinson disease	P01230	Src kinase	CHICK|Gene=FYN|UniProtKB=Q05876	Tyrosine-protein kinase Fyn	IDA	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00038	JAK/STAT signaling pathway	P01031	PIAS	RAT|RGD=1307843|UniProtKB=G3V9T0	Protein Pias1	ISS	8682149	PubMed	PTHR10782:SF11	E3 SUMO-PROTEIN LIGASE PIAS1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	IDA	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00034	Integrin signalling pathway	P00922	Collagen	DANRE|ZFIN=ZDB-GENE-030131-8415|UniProtKB=E9QCG6	Uncharacterized protein	IDA	10778855	PubMed	PTHR24023:SF568	COLLAGEN ALPHA-2 I  CHAIN
P00010	B cell activation	P00394	BLNK	RAT|RGD=1561933|UniProtKB=Q4KM52	B-cell linker protein	ISS	11274146	PubMed	PTHR14098:SF3	B-CELL LINKER PROTEIN
P00021	FGF signaling pathway	P00626	Spry	BOVIN|Ensembl=ENSBTAG00000010245|UniProtKB=F1MIH6	Uncharacterized protein	ISS			PTHR12365:SF9	PROTEIN SPROUTY HOMOLOG 3
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	TAS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00126	Fe65	CANLF|Ensembl=ENSCAFG00000015887|UniProtKB=E2R1T9	Uncharacterized protein	ISS			PTHR14058:SF11	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 2
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	MACMU|Ensembl=ENSMMUG00000013047|UniProtKB=F7H808	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04397	p53 pathway by glucose deprivation	P04641	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=1953|UniProtKB=P08173	Muscarinic acetylcholine receptor M4	IDA	12181435	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	TAS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	G04694	p110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05913	Enkephalin release	P05974	G-Protein (i)	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	SCHMA|EnsemblGenome=Smp_049760|UniProtKB=G4LWP9	Receptor protein serine/threonine kinase	TAS	9395284	PubMed	PTHR23255:SF71	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00049	Parkinson disease	P01230	Src kinase	XENTR|Xenbase=XB-GENE-489820|UniProtKB=F7DXH6	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05913	Enkephalin release	P05972	PKA	MOUSE|MGI=MGI=1309999|UniProtKB=Q922R0	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00018	EGF receptor signaling pathway	P00560	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	SCLS1|Gene=SS1G_08733|UniProtKB=A7ETS6	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02738	De novo purine biosynthesis	P02908	Phosphoribosylamine glycine ligase	ECOLI|EcoGene=EG10799|UniProtKB=P08179	Phosphoribosylglycinamide formyltransferase	ISS			PTHR43369:SF2	PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=96281|UniProtKB=P34968	5-hydroxytryptamine receptor 2C	IDA			PTHR24247:SF32	5-HYDROXYTRYPTAMINE RECEPTOR 2C
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g234494|UniProtKB=A7RU31	Predicted protein	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00004	Alzheimer disease-presenilin pathway	P00114	actin	TAKRU|Ensembl=ENSTRUG00000004787|UniProtKB=P53480	Actin, alpha cardiac	IDA	11889139	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00048	PI3 kinase pathway	P01197	Caspase-9	MOUSE|MGI=MGI=1277950|UniProtKB=Q8C3Q9	Caspase-9	ISS	9390557	PubMed	PTHR10454:SF157	CASPASE-9
P00017	DNA replication	P00527	Histones	ANOGA|EnsemblGenome=AGAP001813|UniProtKB=Q7PUQ8	Histone H3	ISS	12413958	PubMed	PTHR11426:SF179	HISTONE H3.3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	RAT|RGD=2157|UniProtKB=P29067	Beta-arrestin-2	IDA	11742073	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	XENTR|Ensembl=ENSXETG00000030140|UniProtKB=F7EP58	Uncharacterized protein (Fragment)	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00017	DNA replication	P00535	5' to 3' Exoribonulcease	BOVIN|Ensembl=ENSBTAG00000011304|UniProtKB=F1MKX7	Uncharacterized protein	ISS	99339991	PubMed	PTHR12341:SF41	5'-3' EXORIBONUCLEASE 2
P00010	B cell activation	P00383	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	94313981	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00006	Apoptosis signaling pathway	P00274	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00053	T cell activation	P01332	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	YEAST|SGD=S000000028|UniProtKB=P31109	Synaptobrevin homolog 1	ISS	8011337	PubMed	PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00052	TGF-beta signaling pathway	P01275	P38	DROME|FlyBase=FBgn0015765|UniProtKB=O62618	Mitogen-activated protein kinase 14A	TAS	10851062	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_79607|UniProtKB=C3ZHN4	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01179	PKB	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01407	Erk	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	YEAST|SGD=S000005098|UniProtKB=P23292	Casein kinase I homolog 2	IDA	10617630	PubMed	PTHR11909:SF117	CASEIN KINASE I HOMOLOG 1-RELATED
P04393	Ras Pathway	P04555	PDK	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	IDA	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00056	VEGF signaling pathway	P01411	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12932731	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00004	Alzheimer disease-presenilin pathway	P00162	Pro-BACE-1	HUMAN|HGNC=934|UniProtKB=Q9Y5Z0	Beta-secretase 2	IDA			PTHR13683:SF262	BETA-SECRETASE 2
P00060	Ubiquitin proteasome pathway	P01490	E3	MACMU|Ensembl=ENSMMUG00000009461|UniProtKB=F7A9B7	Uncharacterized protein	ISS	11252892	PubMed	PTHR11254:SF300	E3 UBIQUITIN-PROTEIN LIGASE SMURF2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	ORNAN|Ensembl=ENSOANG00000008521|UniProtKB=F6WNA3	Clathrin heavy chain	ISS	9388255	PubMed	PTHR10292:SF7	CLATHRIN HEAVY CHAIN 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=1923396|UniProtKB=Q8BVI5	Syntaxin-16	IC			PTHR19957:SF83	SYNTAXIN-16
P00029	Huntington disease	P00780	Microtubule	DAPPU|EnsemblGenome=DAPPUDRAFT_305638|UniProtKB=E9FWY0	Putative uncharacterized protein	ISS			PTHR11588:SF252	BETA-TUBULIN AT 97EF, ISOFORM B
P00047	PDGF signaling pathway	P01167	Ets	RAT|RGD=1311577|UniProtKB=G3V813	Protein Etv3	ISS	15298723	PubMed	PTHR11849:SF30	ETS TRANSLOCATION VARIANT 3
P02759	Pyridoxal-5-phosphate biosynthesis	P03058	Phosphohydroxythreonine aminotransferase	BOVIN|Ensembl=ENSBTAG00000013960|UniProtKB=A6QR28	Phosphoserine aminotransferase	ISS	2682527	PubMed	PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P00020	FAS signaling pathway	P00611	Gelsolin	BOVIN|Ensembl=ENSBTAG00000005432|UniProtKB=Q865V6	Macrophage-capping protein	ISS	9323209	PubMed	PTHR11977:SF13	MACROPHAGE-CAPPING PROTEIN
P02763	Peptidoglycan biosynthesis	P03088	UDP-N-acetylmuramate dehydrogenase	STRCO|EnsemblGenome=CAB77417|UniProtKB=Q9L0L7	UDP-N-acetylenolpyruvoylglucosamine reductase	ISS			PTHR21071:SF4	UDP-N-ACETYLENOLPYRUVOYLGLUCOSAMINE REDUCTASE
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ARATH|TAIR=AT2G20140|UniProtKB=Q9SL67	26S proteasome regulatory subunit 4 homolog B	ISS			PTHR23073:SF24	26S PROTEASE REGULATORY SUBUNIT 4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MACMU|Ensembl=ENSMMUG00000014597|UniProtKB=F6VAQ6	Glycogen synthase kinase-3 alpha	ISS	14698990	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	HUMAN|HGNC=6696|UniProtKB=O75096	Low-density lipoprotein receptor-related protein 4	IDA	11907044	PubMed	PTHR44017:SF4	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=98327|UniProtKB=P30873	Somatostatin receptor type 1	IDA	12181435	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P00006	Apoptosis signaling pathway	P00305	Caspase 3	MACMU|Ensembl=ENSMMUG00000012053|UniProtKB=F7HFY2	Uncharacterized protein	ISS	9323209	PubMed	PTHR10454:SF198	CASPASE-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	PANTR|Ensembl=ENSPTRG00000008260|UniProtKB=H2QBD7	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	ISS	9133421	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P05915	Opioid proenkephalin pathway	P05994	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	8170357	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00053	T cell activation	P01307	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00029	Huntington disease	P00778	NMDA receptor	HUMAN|HGNC=4586|UniProtKB=Q13224	Glutamate receptor ionotropic, NMDA 2B	IDA	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00036	Interleukin signaling pathway	P00962	ELK	PANTR|Ensembl=ENSPTRG00000005322|UniProtKB=H2Q6N4	ELK3, ETS-domain protein (SRF accessory protein 2)	ISS			PTHR11849:SF172	ETS DOMAIN-CONTAINING PROTEIN ELK-3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ORNAN|Ensembl=ENSOANG00000000460|UniProtKB=F7F4W9	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	DANRE|ZFIN=ZDB-GENE-051202-1|UniProtKB=E7F101	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF2	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	BOVIN|Ensembl=ENSBTAG00000000219|UniProtKB=F1MCL3	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	BOVIN|Ensembl=ENSBTAG00000012927|UniProtKB=A6QLL8	Fructose-bisphosphate aldolase	ISS	84261525	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00047	PDGF signaling pathway	P01162	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00030	Hypoxia response via HIF activation	P00819	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00021	FGF signaling pathway	P00638	PLCgamma	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00018	EGF receptor signaling pathway	P00539	14-3-3	MOUSE|MGI=MGI=109484|UniProtKB=P63101	14-3-3 protein zeta/delta	ISS	1499718	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00591	PLCbeta	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CANLF|Gene=MYH1|UniProtKB=Q076A6	Myosin-1	ISS	89264452	PubMed	PTHR13140:SF484	MYOSIN-1
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05731	GABA-B receptor II signaling	P05754	Ggamma	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ORYSJ|EnsemblGenome=OS06G0699400|UniProtKB=Q5Z859	Mitogen-activated protein kinase 4	ISS	9836510	gi	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00004	Alzheimer disease-presenilin pathway	P00127	APP	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9063|UniProtKB=Q15111	Inactive phospholipase C-like protein 1	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P05731	GABA-B receptor II signaling	P05755	Gbeta	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	ORYSJ|EnsemblGenome=OS01G0282800|UniProtKB=Q43594	Tubulin beta-1 chain	ISS	12932731	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DANRE|ZFIN=ZDB-GENE-041001-104|UniProtKB=Q5TZD4	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000016595|UniProtKB=F6ZDB2	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00010	B cell activation	P00380	fos	PANTR|Ensembl=ENSPTRG00000006553|UniProtKB=A5A6H0	C-fos	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P02788	Xanthine and guanine salvage pathway	P03245	Guanine phosphoribosyl transferase	PLAF7|EnsemblGenome=PF10_0121|UniProtKB=Q8IJS1	Hypoxanthine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	XENTR|Xenbase=XB-GENE-944026|UniProtKB=F6VZM7	Adenosine receptor A1 (Fragment)	ISS	11781138	PubMed	PTHR24246:SF1	ADENOSINE RECEPTOR A1
P00057	Wnt signaling pathway	P01457	GBeta	BOVIN|Ensembl=ENSBTAG00000006495|UniProtKB=P11017	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IDA	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04397	p53 pathway by glucose deprivation	P04641	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00238	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	87226391	PubMed	PTHR24070:SF385	GTPASE HRAS
P05731	GABA-B receptor II signaling	P05752	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	RCA	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04558	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00830	Lipoxygenase	BOVIN|Ensembl=ENSBTAG00000011990|UniProtKB=P27479	Arachidonate 15-lipoxygenase	TAS	12432925	PubMed	PTHR11771:SF33	ARACHIDONATE 15-LIPOXYGENASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	RCA	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	9199552	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P05916	Opioid prodynorphin pathway	P06001	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00060	Ubiquitin proteasome pathway	P01490	E3	ORNAN|Ensembl=ENSOANG00000006137|UniProtKB=F6PLU9	Uncharacterized protein	ISS			PTHR11254:SF357	UBIQUITIN-PROTEIN LIGASE E3C
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	HUMAN|HGNC=4580|UniProtKB=Q13002	Glutamate receptor ionotropic, kainate 2	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00046	Oxidative stress response	P01135	p38	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	TAS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00004	Alzheimer disease-presenilin pathway	P00111	C99	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00054	Toll receptor signaling pathway	P01375	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00006	Apoptosis signaling pathway	P00318	PKCs	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00059	p53 pathway	P01486	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00628	JNK1-3	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00052	TGF-beta signaling pathway	P01286	TGFbeta	BOVIN|Ensembl=ENSBTAG00000005176|UniProtKB=F6S0Q2	Uncharacterized protein	ISS	9759503	PubMed	PTHR12173:SF1	GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00634	MEKK1-5	MACMU|Ensembl=ENSMMUG00000018318|UniProtKB=F7HFE8	Uncharacterized protein	ISS	9875215	PubMed	PTHR11584:SF391	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 6
P00047	PDGF signaling pathway	P01173	STAT	CANLF|Ensembl=ENSCAFG00000015213|UniProtKB=E2RB82	Signal transducer and activator of transcription	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04393	Ras Pathway	P04556	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	IDA	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	DROME|FlyBase=FBgn0015781|UniProtKB=Q9V3F8	Pyrroline-5-carboxylate reductase	ISS			PTHR11645:SF0	PYRROLINE-5-CARBOXYLATE REDUCTASE
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	DICDI|dictyBase=DDB_G0277143|UniProtKB=P36408	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00018	EGF receptor signaling pathway	P00556	PLCgamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IGI	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00024	Glycolysis	P00679	Aldolase	RAT|RGD=1359133|UniProtKB=Q6AY07	Fructose-bisphosphate aldolase	ISS	74094688	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	RAT|RGD=71027|UniProtKB=P42264	Glutamate receptor ionotropic, kainate 3	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	HUMAN|HGNC=4044|UniProtKB=O60353	Frizzled-6	TAS	11212302	PubMed	PTHR11309:SF75	FRIZZLED-6
P00029	Huntington disease	P00807	Actin	CHICK|Ensembl=ENSGALG00000014620|UniProtKB=F1N8P3	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00021	FGF signaling pathway	P00634	MEKK1-5	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS	602425	OMIM	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00005	Angiogenesis	P00206	Wnt	DANRE|ZFIN=ZDB-GENE-990415-278|UniProtKB=P43446	Protein Wnt-10a	ISS	8717036	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	HUMAN|HGNC=1389|UniProtKB=Q00975	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	14507926	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00029	Huntington disease	P00807	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g242065|UniProtKB=A7S0V7	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02761	Pantothenate biosynthesis	P03068	Pantoate-beta-alanine ligase	THEMA|EnsemblGenome=TM_1077|UniProtKB=Q9X0G6	Pantothenate synthetase	ISS			PTHR21299:SF1	PANTOATE--BETA-ALANINE LIGASE
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	PANTR|Ensembl=ENSPTRG00000017238|UniProtKB=H2QRH7	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	TAKRU|Ensembl=ENSTRUG00000008289|UniProtKB=H2T7U8	Uncharacterized protein	ISS	9658176	PubMed	PTHR24072:SF129	CDC42L PROTEIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	GIAIC|EnsemblGenome=GL50803_96994|UniProtKB=E2RTW9	Syntaxin 1A	IC			PTHR19957:SF41	SYNTAXIN-1A
P00018	EGF receptor signaling pathway	P00564	Rac	CAEEL|WormBase=WBGene00004287|UniProtKB=Q94124	Ras-related protein rac-2	IGI	12932731	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04393	Ras Pathway	P04568	MKK3/6	RAT|RGD=1306620|UniProtKB=B1H230	Map2k3 protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00034	Integrin signalling pathway	P00916	Ras	DAPPU|EnsemblGenome=DAPPUDRAFT_301818|UniProtKB=E9I1I7	Putative uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	ORNAN|Ensembl=ENSOANG00000004058|UniProtKB=F6TYP9	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IGI	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	RAT|RGD=1306882|UniProtKB=B4F7A9	Casein kinase 2, alpha prime polypeptide	ISS	10806215	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	IXOSC|EnsemblGenome=ISCW009711|UniProtKB=B7Q3T6	THO complex subunit, putative	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00023	General transcription regulation	P00667	TFIIFbeta	CANLF|Ensembl=ENSCAFG00000012900|UniProtKB=E2RGQ0	Uncharacterized protein	ISS	92020241	PubMed	PTHR10445:SF0	GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2
P00029	Huntington disease	P00811	Arp2/3 complex	MONDO|Ensembl=ENSMODG00000019755|UniProtKB=F6WN64	Actin-related protein 2/3 complex subunit 5	ISS	12932731	PubMed	PTHR12644:SF2	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5-LIKE PROTEIN
P04396	Vitamin D metabolism and pathway	P04607	FDX	ECOLI|EcoGene=EG11328|UniProtKB=P0A9R4	2Fe-2S ferredoxin	ISS			PTHR23426:SF34	2FE-2S FERREDOXIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00034	Integrin signalling pathway	P00924	Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	IPI	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00049	Parkinson disease	P01211	ERK	MACMU|Ensembl=ENSMMUG00000008536|UniProtKB=F6WBZ5	Mitogen-activated protein kinase	ISS	15085193	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	IC	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01443	Phospholipase C	CAEEL|WormBase=WBGene00004037|UniProtKB=Q9XWB7	Phosphoinositide phospholipase C	IDA	1707501	PubMed	PTHR10336:SF9	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P02741	Flavin biosynthesis	P02936	FAD synthetase	HUMAN|HGNC=24671|UniProtKB=Q8NFF5	FAD synthase	RCA			PTHR23293:SF9	FAD SYNTHASE
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05913	Enkephalin release	G06045	preproenkephalin	MACMU|Ensembl=ENSMMUG00000009984|UniProtKB=F6R267	Beta-neoendorphin-dynorphin	ISS	131330	OMIM	PTHR11438:SF4	PROENKEPHALIN-B
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8972|UniProtKB=O00750	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00006	Apoptosis signaling pathway	P00310	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01190	PDK1 ACT	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	15210700	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	ARATH|TAIR=AT4G31170|UniProtKB=Q9M085	AT4G31170 protein	ISS			PTHR23257:SF618	SERINE/THREONINE/TYROSINE KINASE-RELATED
P02738	De novo purine biosynthesis	P02902	ADP reductase	MOUSE|MGI=MGI=98180|UniProtKB=P07742	Ribonucleoside-diphosphate reductase large subunit	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00951	Jnk	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IDA	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04375	5HT3 type receptor mediated signaling pathway	P04421	5HT transporter	HUMAN|HGNC=11050|UniProtKB=P31645	Sodium-dependent serotonin transporter	ISS	7681602	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	MONDO|Ensembl=ENSMODG00000025188|UniProtKB=F7C1G3	Uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00564	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00021	FGF signaling pathway	P00648	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00034	Integrin signalling pathway	P00907	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00009	Axon guidance mediated by netrin	P00356	UNC-5	MOUSE|MGI=MGI=894703|UniProtKB=Q8K1S3	Netrin receptor UNC5B	ISS			PTHR12582:SF6	NETRIN RECEPTOR UNC5B
P04393	Ras Pathway	P04563	Ets	MONDO|Ensembl=ENSMODG00000004730|UniProtKB=F6Y1Z2	Uncharacterized protein	ISS	15579511	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00005	Angiogenesis	P00236	PI3K	XENTR|Xenbase=XB-GENE-6067221|UniProtKB=F6Z0J4	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P05915	Opioid proenkephalin pathway	P05994	G-protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00017	DNA replication	P00527	Histones	PLAF7|EnsemblGenome=PFF0510w|UniProtKB=C6KSV0	Histone H3	ISS	12413958	PubMed	PTHR11426:SF169	HISTONE H3
P00049	Parkinson disease	P01236	Casein kinase II	ARATH|TAIR=AT2G44680|UniProtKB=O80507	Putative casein kinase II subunit beta-4	IDA	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01143	ERK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	CHICK|Gene=PSEN2|UniProtKB=Q90X07	Presenilin-2	TAS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00004	Alzheimer disease-presenilin pathway	P00147	TACE	MOUSE|MGI=MGI=1096335|UniProtKB=Q9Z0F8	Disintegrin and metalloproteinase domain-containing protein 17	TAS	12834808	PubMed	PTHR11905:SF171	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00023	General transcription regulation	P00666	TFIIE	HUMAN|HGNC=4650|UniProtKB=P29083	General transcription factor IIE subunit 1	ISS	189964	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	ANOGA|EnsemblGenome=AGAP001394|UniProtKB=F5HMS4	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00006	Apoptosis signaling pathway	P00318	PKCs	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	TAKRU|Ensembl=ENSTRUG00000016101|UniProtKB=H2UW32	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00021	FGF signaling pathway	P00624	14-3-3	CHICK|Gene_ORFName=RCJMB04_5e12|UniProtKB=Q5F3W6	14-3-3 protein gamma	ISS	10407019	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05731	GABA-B receptor II signaling	P05752	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00029	Huntington disease	P00805	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05918	p38 MAPK pathway	P06035	TAB1	HUMAN|HGNC=18157|UniProtKB=Q15750	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1	RCA	10838074	PubMed	PTHR13832:SF533	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1
P00047	PDGF signaling pathway	P01161	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	TAS	12040174	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00012	Cadherin signaling pathway	P00462	Casein kinase II	CAEEL|WormBase=WBGene00002196|UniProtKB=P28548	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IDA	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00182	p38MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00048	PI3 kinase pathway	P01192	p110	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00101	BACE-1	MOUSE|MGI=MGI=1346542|UniProtKB=P56818	Beta-secretase 1	IDA	10531052	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	BACSU|EnsemblGenome=BSU25600|UniProtKB=P39696	ComE operon protein 4	ISS			PTHR11645:SF0	PYRROLINE-5-CARBOXYLATE REDUCTASE
P00010	B cell activation	P00374	Lyn	MACMU|Ensembl=ENSMMUG00000014149|UniProtKB=F7BV42	Tyrosine-protein kinase	ISS	1371009	PubMed	PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ASHGO|EnsemblGenome=AGOS_ABR222W|UniProtKB=Q75D00	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00021	FGF signaling pathway	P00643	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04397	p53 pathway by glucose deprivation	P04641	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01332	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00010	B cell activation	P00376	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00566	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00019	Endothelin signaling pathway	P00572	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IGI	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00056	VEGF signaling pathway	P01411	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00049	Parkinson disease	P01242	Casein kinase I	CANLF|Ensembl=ENSCAFG00000019435|UniProtKB=E2QX25	Uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF157	CASEIN KINASE I ISOFORM GAMMA-2
P04393	Ras Pathway	P04542	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00005	Angiogenesis	P00223	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000003399|UniProtKB=H2Q383	Phosphoinositide-3-kinase, class 2, alpha polypeptide	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P02723	Adenine and hypoxanthine salvage pathway	P02804	Hypoxanthine phosphoribosyl transferase	HUMAN|HGNC=23333|UniProtKB=Q9NRG1	Phosphoribosyltransferase domain-containing protein 1	ISS			PTHR43340:SF5	PHOSPHORIBOSYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	MOUSE|MGI=MGI=102522|UniProtKB=Q8R3Z5	Voltage-dependent L-type calcium channel subunit beta-1	ISS	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00056	VEGF signaling pathway	P01421	Rac	MOUSE|MGI=MGI=2180784|UniProtKB=P60764	Ras-related C3 botulinum toxin substrate 3	RCA			PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	TAS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00018	EGF receptor signaling pathway	P00555	MKK4,7	MACMU|Ensembl=ENSMMUG00000019842|UniProtKB=F7FU91	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00057	Wnt signaling pathway	P01465	Ggamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00006	Apoptosis signaling pathway	P00269	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00012	Cadherin signaling pathway	P00470	F-actin	DICDI|dictyBase=DDB_G0289811|UniProtKB=Q54GX7	Actin-10	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	9094314	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	RCA	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P02776	Serine glycine biosynthesis	P03160	Phosphoglycerate dehydrogenase	MYCTU|EnsemblGenome=Rv2996c|UniProtKB=P9WNX3	D-3-phosphoglycerate dehydrogenase	ISS			PTHR42938:SF9	FORMATE DEHYDROGENASE 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	TAS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00048	PI3 kinase pathway	P01177	P110ACT	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00928	alpha actinin	HUMAN|HGNC=164|UniProtKB=P35609	Alpha-actinin-2	IPI	2116421	PubMed	PTHR43947:SF4	ALPHA-ACTININ-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	XENTR|Xenbase=XB-GENE-491618|UniProtKB=Q6P378	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P02757	O-antigen biosynthesis	P03045	dTDP-glucose 4,6-dehydratase	ARATH|TAIR=AT1G53500|UniProtKB=Q9LPG6	Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM2	ISS			PTHR43000:SF8	TRIFUNCTIONAL UDP-GLUCOSE 4,6-DEHYDRATASE/UDP-4-KETO-6-DEOXY-D-GLUCOSE 3,5-EPIMERASE/UDP-4-KETO-L-RHAMNOSE-REDUCTASE RHM1-RELATED
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CANLF|Ensembl=ENSCAFG00000013332|UniProtKB=F1PCQ4	Uncharacterized protein	ISS	11390664	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00053	T cell activation	P01337	B7	HUMAN|HGNC=1700|UniProtKB=P33681	T-lymphocyte activation antigen CD80	IDA	1650475	PubMed	PTHR25466:SF4	T-LYMPHOCYTE ACTIVATION ANTIGEN CD80
P00012	Cadherin signaling pathway	P00462	Casein kinase II	RAT|RGD=621663|UniProtKB=P19139	Casein kinase II subunit alpha	ISS	10806215	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00093	Tip60	RAT|RGD=620844|UniProtKB=O35430	Amyloid beta A4 precursor protein-binding family A member 1	IC			PTHR12345:SF14	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 1
P00025	Hedgehog signaling pathway	P00692	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00049	Parkinson disease	P01236	Casein kinase II	PANTR|Ensembl=ENSPTRG00000017974|UniProtKB=H2QSN4	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00048	PI3 kinase pathway	P01199	Galpha	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00029	Huntington disease	P00776	c-Jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P06002	G-protein	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF31	SUBFAMILY NOT NAMED
P05915	Opioid proenkephalin pathway	P05994	G-protein	MONDO|Ensembl=ENSMODG00000005623|UniProtKB=F7CFG8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	BOVIN|Ensembl=ENSBTAG00000008151|UniProtKB=F1MH06	Uncharacterized protein	ISS	9006902	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00010	B cell activation	P00376	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00021	FGF signaling pathway	P00624	14-3-3	EMENI|EnsemblGenome=CADANIAG00005943|UniProtKB=Q5B4M9	1433_TRIHA 14-3-3 PROTEIN HOMOLOG (TH1433)	IGI	22017897	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00025	Hedgehog signaling pathway	P00682	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00010	B cell activation	P00375	Calmodulin	MONDO|Ensembl=ENSMODG00000025146|UniProtKB=F7CLC0	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF311	CALMODULIN
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	PANTR|Gene=ALDOC|UniProtKB=Q5R1X4	Fructose-bisphosphate aldolase C	IEP	7768978	PubMed	PTHR11627:SF3	FRUCTOSE-BISPHOSPHATE ALDOLASE C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IDA	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00008	Axon guidance mediated by Slit/Robo	P00344	Netrin	BOVIN|Ensembl=ENSBTAG00000045625|UniProtKB=G3N0E7	Netrin 3	ISS			PTHR10574:SF292	NETRIN-3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00318	PKCs	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	90172230	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05726	2-arachidonoylglycerol biosynthesis	P05736	DGL	MOUSE|MGI=MGI=96820|UniProtKB=P11152	Lipoprotein lipase	RCA			PTHR11610:SF3	LIPOPROTEIN LIPASE
P00023	General transcription regulation	P00669	TFIIEalpha	MOUSE|MGI=MGI=1921447|UniProtKB=Q9D0D5	General transcription factor IIE subunit 1	ISS	92065982	PubMed	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00019	Endothelin signaling pathway	P00586	Gq	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00551	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	IC	11319238	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00005	Angiogenesis	P00254	GTPase	ORNAN|Ensembl=ENSOANG00000008835|UniProtKB=F7FR08	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00641	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	HUMAN|HGNC=7777|UniProtKB=Q12968	Nuclear factor of activated T-cells, cytoplasmic 3	ISS	9462517	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00034	Integrin signalling pathway	P00907	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	DICPU|Gene=DICPUDRAFT_45258|UniProtKB=F0Z9S5	Clathrin heavy chain	ISS	9388255	PubMed	PTHR10292:SF1	CLATHRIN HEAVY CHAIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P02753	Methionine biosynthesis	P03025	Cystathionine lyase	YEAST|SGD=S000001952|UniProtKB=P43623	Putative cystathionine beta-lyase	ISS			PTHR43500:SF1	CYSTATHIONINE BETA-LYASE-RELATED
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IDA	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00052	TGF-beta signaling pathway	P01275	P38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	RAT|RGD=619858|UniProtKB=P70579	Metabotropic glutamate receptor 8	IC	9407094	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00048	PI3 kinase pathway	P01185	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00017	DNA replication	P00528	Primase	HUMAN|HGNC=9369|UniProtKB=P49642	DNA primase small subunit	ISS	10441007	PubMed	PTHR10536:SF0	DNA PRIMASE SMALL SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	HUMAN|HGNC=4404|UniProtKB=P59768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IDA	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00053	T cell activation	P01298	NFkappaB	RAT|RGD=70498|UniProtKB=Q63369	Nuclear factor NF-kappa-B p105 subunit (Fragment)	ISS	8598461	PubMed	PTHR24169:SF9	NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	MOUSE|MGI=MGI=95602|UniProtKB=P39688	Tyrosine-protein kinase Fyn	ISS	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P04398	p53 pathway feedback loops 2	P04651	Ras	DANRE|ZFIN=ZDB-GENE-040808-67|UniProtKB=Q6AZA4	K-ras	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00036	Interleukin signaling pathway	P00964	p90RSK	BOVIN|Ensembl=ENSBTAG00000021741|UniProtKB=F1MNR5	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	IDA	12885769	PubMed	PTHR10202:SF13	PRESENILIN-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	CHICK|Ensembl=ENSGALG00000003806|UniProtKB=O93467	GTP-binding protein	ISS	12169092	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00034	Integrin signalling pathway	P00907	ERK	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	ISS			PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00005	Angiogenesis	P00227	PLA2	PANTR|Ensembl=ENSPTRG00000001787|UniProtKB=H2Q0T0	Phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	MOUSE|MGI=MGI=109482|UniProtKB=P97445	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	8386525	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CHICK|Ensembl=ENSGALG00000009621|UniProtKB=P60706	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P05916	Opioid prodynorphin pathway	P06000	vasopressin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CAEEL|WormBase=WBGene00000103|UniProtKB=Q9XTG7	Serine/threonine-protein kinase akt-2	TAS	12089061	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00006	Apoptosis signaling pathway	P00274	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=3023|UniProtKB=P14416	D(2) dopamine receptor	IDA	11248120	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	RAT|RGD=2732|UniProtKB=P22756	Glutamate receptor ionotropic, kainate 1	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00010	B cell activation	P00397	IKK	BOVIN|Ensembl=ENSBTAG00000007591|UniProtKB=Q95KV1	Inhibitor of nuclear factor kappa-B kinase subunit alpha	IGI	12813046	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00005	Angiogenesis	P00236	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS			PTHR10048:SF14	PI-3 KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	RAT|RGD=2091|UniProtKB=P09117	Fructose-bisphosphate aldolase C	ISS	3105602	PubMed	PTHR11627:SF3	FRUCTOSE-BISPHOSPHATE ALDOLASE C
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	RAT|RGD=628816|UniProtKB=G3V6L1	Frizzled homolog 6 (Drosophila)	ISS	8717036	PubMed	PTHR11309:SF75	FRIZZLED-6
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00029	Huntington disease	P00763	Hip-12	MACMU|Ensembl=ENSMMUG00000015221|UniProtKB=F6VW84	Uncharacterized protein	RCA			PTHR10407:SF10	HUNTINGTIN-INTERACTING PROTEIN 1-RELATED PROTEIN
P00034	Integrin signalling pathway	P00925	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00048	PI3 kinase pathway	P01199	Galpha	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00048	PI3 kinase pathway	P01179	PKB	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01425	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P06664	Gonadotropin-releasing hormone receptor pathway	P06812	L-type Ca2+	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	RCA	91056091	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00036	Interleukin signaling pathway	P00979	MAPKAPK2	MACMU|Ensembl=ENSMMUG00000023567|UniProtKB=F7HHY8	Uncharacterized protein	ISS	7923354	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00739	AGS3	BOVIN|Ensembl=ENSBTAG00000018799|UniProtKB=G3N266	Uncharacterized protein	ISS	11121039	PubMed	PTHR10098:SF36	G-PROTEIN-SIGNALING MODULATOR 1
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-040426-2280|UniProtKB=Q6P025	Gnb3 protein	ISS			PTHR19850:SF35	GNB3 PROTEIN
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00029	Huntington disease	P00805	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06831	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	RCA	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01437	TCF	BOVIN|Ensembl=ENSBTAG00000010111|UniProtKB=F1MJS2	Uncharacterized protein	ISS	9118222	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	TAS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04397	p53 pathway by glucose deprivation	P04641	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00059	p53 pathway	P01480	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	188830	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00009	Axon guidance mediated by netrin	P00366	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12874273	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	CHICK|Ensembl=ENSGALG00000000681|UniProtKB=E1C3P6	Uncharacterized protein	ISS	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00005	Angiogenesis	P00253	Axin	CHICK|Gene=AXIN1|UniProtKB=O42400	Axin-1	ISS	9554852	PubMed	PTHR10845:SF11	AXIN-1
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05731	GABA-B receptor II signaling	P05755	Gbeta	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IGI	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	RCA			PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00010	B cell activation	P00381	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00221	JNK1	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00556	PLCgamma	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00034	Integrin signalling pathway	P00947	Laminin	PANTR|Ensembl=ENSPTRG00000018588|UniProtKB=H2QTQ4	Uncharacterized protein	ISS	2538453	PubMed	PTHR10574:SF291	LAMININ SUBUNIT ALPHA-2
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=2685045|UniProtKB=E9QAN8	Protein Pik3c2b	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00010	B cell activation	P00381	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02916	dTMP kinase	RAT|RGD=1309614|UniProtKB=D3ZUJ5	Deoxythymidylate kinase (Predicted), isoform CRA_b	ISS			PTHR10344:SF1	THYMIDYLATE KINASE
P00056	VEGF signaling pathway	P01407	Erk	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CANLF|Ensembl=ENSCAFG00000008653|UniProtKB=F1PE26	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00012	Cadherin signaling pathway	P00471	Cadherin	BOVIN|Ensembl=ENSBTAG00000019977|UniProtKB=F1N2W7	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF0	PROTOCADHERIN-10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00049	Parkinson disease	P01219	SAPK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	PANTR|Ensembl=ENSPTRG00000019361|UniProtKB=H2QUV3	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00015	Circadian clock system	P00504	Per	RAT|RGD=727863|UniProtKB=Q8CHI5	Period circadian protein homolog 1	ISS	12782655	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CANLF|Ensembl=ENSCAFG00000013148|UniProtKB=Q5R1P3	Glutamate receptor ionotropic, NMDA 2B	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00898	FKHR	HUMAN|HGNC=3821|UniProtKB=O43524	Forkhead box protein O3	ISS	15031210	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00018	EGF receptor signaling pathway	P00551	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00796	Kainate receptor	CHICK|Ensembl=ENSGALG00000002098|UniProtKB=F1P0L4	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00012	Cadherin signaling pathway	P00470	F-actin	CAEEL|WormBase=WBGene00000066|UniProtKB=P10986	Actin-4	IC	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IC	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	CANLF|Ensembl=ENSCAFG00000012353|UniProtKB=E2RSE6	Uncharacterized protein	ISS	11861638	PubMed	PTHR42884:SF1	FURIN
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00034	Integrin signalling pathway	P00931	Integrin beta	MOUSE|MGI=MGI=96612|UniProtKB=O54890	Integrin beta-3	IDA	3487386	PubMed	PTHR10082:SF25	INTEGRIN BETA-3
P00056	VEGF signaling pathway	P01401	HIF-1	MACMU|Ensembl=ENSMMUG00000021002|UniProtKB=F7HKJ2	Uncharacterized protein	ISS	14526383	PubMed	PTHR23043:SF7	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA
P00006	Apoptosis signaling pathway	P00269	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	11554554	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P02738	De novo purine biosynthesis	P02905	Amidophosphoribosyl transferase	STRCO|Gene=CAB56366|UniProtKB=Q7AKK3	Amidophosphoribosyltransferase	ISS			PTHR11907:SF0	AMIDOPHOSPHORIBOSYLTRANSFERASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-7595|UniProtKB=Q6PBR4	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00034	Integrin signalling pathway	P00944	Actin	MONDO|Ensembl=ENSMODG00000002647|UniProtKB=F7DIB7	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	IC	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00048	PI3 kinase pathway	P01199	Galpha	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	IC	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00049	Parkinson disease	P01227	20S proteasome	LEIMA|EnsemblGenome=LmjF.35.4850|UniProtKB=E9AFW0	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF11	PROTEASOME SUBUNIT ALPHA TYPE-6
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	MOUSE|MGI=MGI=1351342|UniProtKB=Q3UVX5	Metabotropic glutamate receptor 5	ISS	92317054	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01080	AChE	CHICK|Ensembl=ENSGALG00000009478|UniProtKB=F1NV99	Carboxylic ester hydrolase	IC			PTHR43918:SF5	CHOLINESTERASE
P00047	PDGF signaling pathway	P01142	p90RSK	MACMU|Ensembl=ENSMMUG00000022111|UniProtKB=F7H7W3	Ribosomal protein S6 kinase	ISS	12769834	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	RCA	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05915	Opioid proenkephalin pathway	P05994	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00018	EGF receptor signaling pathway	P00547	PP2A	ARATH|TAIR=AT3G26020|UniProtKB=Q9LU89	Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' eta isoform	ISS			PTHR10257:SF46	SERINE/THREONINE PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B' DELTA ISOFORM-RELATED
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	DANRE|ZFIN=ZDB-GENE-980605-30|UniProtKB=Q9YHE8	Transcription factor 7-like 1-A	TAS	12356903	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00005	Angiogenesis	P00237	FRP	HUMAN|HGNC=4041|UniProtKB=Q9NPG1	Frizzled-3	IC	12549854	PubMed	PTHR11309:SF22	FRIZZLED-3
P00005	Angiogenesis	P00206	Wnt	CHICK|Ensembl=ENSGALG00000005410|UniProtKB=Q9YGX6	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04625	Cdk2	MACMU|Ensembl=ENSMMUG00000018817|UniProtKB=F6ZHC1	Uncharacterized protein	ISS	1846803	PubMed	PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02751	Lysine biosynthesis	P03011	N-succinyldiaminopimelate  aminotransferase	NEUCR|EnsemblGenome=EFNCRG00000006536|UniProtKB=Q9P3I3	Acetylornithine aminotransferase, mitochondrial	IDA			PTHR11986:SF79	ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MACMU|Ensembl=ENSMMUG00000018445|UniProtKB=F7HEW6	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	ARATH|TAIR=AT1G13890|UniProtKB=Q9LMG8	Putative SNAP25 homologous protein SNAP30	IC			PTHR19305:SF7	SNAP25 HOMOLOGOUS PROTEIN SNAP30-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00942	Fyn	MONDO|Ensembl=ENSMODG00000017905|UniProtKB=F7FG65	Tyrosine-protein kinase	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P05916	Opioid prodynorphin pathway	P06002	G-protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	ISS	10188796	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	CAEEL|WormBase=WBGene00002173|UniProtKB=Q9Y0A1	Inositol 1,4,5-trisphosphate receptor itr-1	ISS	11007872	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	HUMAN|HGNC=11509|UniProtKB=P21579	Synaptotagmin-1	IDA	1589771	PubMed	PTHR10024:SF239	SYNAPTOTAGMIN-1
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	HUMAN|HGNC=17928|UniProtKB=Q9P2W1	Homologous-pairing protein 2 homolog	ISS	20267852	PubMed	PTHR15938:SF0	HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG
P00015	Circadian clock system	G01497	cry	HUMAN|HGNC=2384|UniProtKB=Q16526	Cryptochrome-1	IDA	10428031	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	XENTR|Xenbase=XB-GENE-1010483|UniProtKB=F7AF72	Uncharacterized protein	ISS	20112749	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	RAT|RGD=1307690|UniProtKB=D4A0I8	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (Predicted), isoform CRA_b	ISS	12787506	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	RCA	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00996	STAT	CHICK|Ensembl=ENSGALG00000003267|UniProtKB=Q6DV79	Signal transducer and activator of transcription 3	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00034	Integrin signalling pathway	P00922	Collagen	HUMAN|HGNC=2185|UniProtKB=Q03692	Collagen alpha-1(X) chain	IDA	10778855	PubMed	PTHR44057:SF5	COLLAGEN ALPHA-1 X  CHAIN
P00021	FGF signaling pathway	P00640	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05754	Ggamma	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	RCA	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	ISS	14744463	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00021	FGF signaling pathway	P00643	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00011	Blood coagulation	P00457	Thrombomodulin	PANTR|Ensembl=ENSPTRG00000013317|UniProtKB=H2QK24	Thrombomodulin	ISS	4507483	gi	PTHR24036:SF5	THROMBOMODULIN
P00048	PI3 kinase pathway	P01199	Galpha	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02734	Chorismate biosynthesis	P02874	Shikimate kinase	RHOBA|EnsemblGenome=RB3471|UniProtKB=Q7UU71	Shikimate kinase	ISS			PTHR21087:SF16	SHIKIMATE KINASE 1, CHLOROPLASTIC-RELATED
P00052	TGF-beta signaling pathway	P01275	P38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	TAS	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00057	Wnt signaling pathway	P01452	NFAT	PANTR|Ensembl=ENSPTRG00000008260|UniProtKB=H2QBD7	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	ISS	9462517	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P04393	Ras Pathway	P04552	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IC	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IDA	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01390	TFIIA complex	PANTR|Ensembl=ENSPTRG00000006596|UniProtKB=H2Q8Q5	General transcription factor IIA, 1, 19/37kDa	ISS	600519	OMIM	PTHR12694:SF7	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	PANTR|Ensembl=ENSPTRG00000029908|UniProtKB=H2R050	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF90	FRIZZLED-8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF31	SUBFAMILY NOT NAMED
P02736	Coenzyme A biosynthesis	P02885	Pantothenate kinase	HUMAN|HGNC=15894|UniProtKB=Q9BZ23	Pantothenate kinase 2, mitochondrial	ISS			PTHR12280:SF25	PANTOTHENATE KINASE 2, MITOCHONDRIAL
P05916	Opioid prodynorphin pathway	P06002	G-protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00054	Toll receptor signaling pathway	P01369	MKK1	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00005	Angiogenesis	P00227	PLA2	CHICK|Ensembl=ENSGALG00000005065|UniProtKB=P49147	Cytosolic phospholipase A2	ISS	94299545	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	ANOGA|EnsemblGenome=AGAP003021|UniProtKB=Q7PQY9	Clathrin heavy chain	IDA	9388255	PubMed	PTHR10292:SF1	CLATHRIN HEAVY CHAIN
P05913	Enkephalin release	P05972	PKA	STRPU|EnsemblGenome=SPU_018419|UniProtKB=W4YRI6	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01160	IP3 receptor	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	MACMU|Ensembl=ENSMMUG00000023736|UniProtKB=F7G778	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P00048	PI3 kinase pathway	P01190	PDK1 ACT	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	IDA	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05949	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8316835	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	CAEEL|WormBase=WBGene00000391|UniProtKB=Q22922	CytiDine Deaminase	ISS	17551074	gi	PTHR11644:SF11	CYTIDINE DEAMINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TAKRU|Ensembl=ENSTRUG00000014318|UniProtKB=H2UI49	Uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00005	Angiogenesis	P00238	Ras	DICPU|Gene=DICPUDRAFT_57324|UniProtKB=F0ZVH9	Putative uncharacterized protein rasS	ISS			PTHR24070:SF380	RAS-LIKE PROTEIN RASS
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00034	Integrin signalling pathway	P00911	B-Raf	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P02759	Pyridoxal-5-phosphate biosynthesis	P03058	Phosphohydroxythreonine aminotransferase	MACMU|Ensembl=ENSMMUG00000011868|UniProtKB=F7H2J8	Phosphoserine aminotransferase	ISS	20886743	gi	PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	BOVIN|Ensembl=ENSBTAG00000007882|UniProtKB=G3X7Z2	Uncharacterized protein	ISS	14624853	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00018	EGF receptor signaling pathway	P00565	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IGI	21157398	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P05731	GABA-B receptor II signaling	P05754	Ggamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00048	PI3 kinase pathway	P01188	Gbetagamma	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00029	Huntington disease	P00786	ARF	XENTR|Xenbase=XB-GENE-950251|UniProtKB=Q6NT85	ADP-ribosylation factor 1	ISS	11752622	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05913	Enkephalin release	P05973	GPCR (i)	RAT|RGD=3233|UniProtKB=P33533	Delta-type opioid receptor	ISS	11259487	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04393	Ras Pathway	P04578	Rho	XENTR|Xenbase=XB-GENE-489222|UniProtKB=Q28GJ8	Ras homolog gene family, member A	ISS	15668138	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	HUMAN|HGNC=6270|UniProtKB=Q92806	G protein-activated inward rectifier potassium channel 3	IDA	12374786	PubMed	PTHR11767:SF17	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 3
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00021	FGF signaling pathway	P00640	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06587	Nicotine pharmacodynamics pathway	P06601	FLNA	MACMU|Ensembl=ENSMMUG00000013668|UniProtKB=F7GCM2	Uncharacterized protein	ISS	11911837	PubMed	PTHR43998:SF6	FILAMIN-A
P04392	P53 pathway feedback loops 1	P04536	Mdm2	HUMAN|HGNC=6974|UniProtKB=O15151	Protein Mdm4	ISS			PTHR13844:SF20	PROTEIN MDM4
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00010	B cell activation	P00373	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IGI	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	IDA	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P02755	Methylmalonyl pathway	P03033	Propionyl-CoA carboxylase	MOUSE|MGI=MGI=97499|UniProtKB=Q91ZA3	Propionyl-CoA carboxylase alpha chain, mitochondrial	ISS			PTHR18866:SF104	PROPIONYL-COA CARBOXYLASE ALPHA CHAIN, MITOCHONDRIAL
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PRIPA|Gene=PPA02894|UniProtKB=H3DZP3	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF120	SUBFAMILY NOT NAMED
P05915	Opioid proenkephalin pathway	P05994	G-protein	CANLF|Ensembl=ENSCAFG00000028654|UniProtKB=J9P702	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	ARATH|TAIR=AT1G07880|UniProtKB=Q9LQQ9	Mitogen-activated protein kinase 13	TAS			PTHR24055:SF185	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00015	Circadian clock system	G01501	cry	MOUSE|MGI=MGI=1270841|UniProtKB=P97784	Cryptochrome-1	IDA	14507900	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00052	TGF-beta signaling pathway	P01292	RSmads	BOVIN|Ensembl=ENSBTAG00000021772|UniProtKB=F1MD43	Mothers against decapentaplegic homolog	ISS	12736218	PubMed	PTHR13703:SF36	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00060	Ubiquitin proteasome pathway	P01492	E1	MOUSE|MGI=MGI=1929264|UniProtKB=Q9R1T2	SUMO-activating enzyme subunit 1	ISS			PTHR10953:SF162	SUMO-ACTIVATING ENZYME SUBUNIT 1
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	EMENI|EnsemblGenome=CADANIAG00005600|UniProtKB=P38094	Protein fluG	ISS			PTHR43785:SF2	TYPE-1 GLUTAMINE SYNTHETASE 1
P04393	Ras Pathway	P04556	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00174	CD44 N-terminal fragment	CHICK|Ensembl=ENSGALG00000007849|UniProtKB=F1NL98	Uncharacterized protein	IDA	12223485	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04395	Vasopressin synthesis	P04594	Neurophysin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00056	VEGF signaling pathway	P01413	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	12660731	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00057	Wnt signaling pathway	P01452	NFAT	BOVIN|Ensembl=ENSBTAG00000004368|UniProtKB=F1MSU2	Uncharacterized protein	ISS	12787506	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9441|UniProtKB=P51817	cAMP-dependent protein kinase catalytic subunit PRKX	IC	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00047	PDGF signaling pathway	P01162	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00055	Transcription regulation by bZIP transcription factor	P01398	TFIIEalpha	CAEEL|WormBase=WBGene00013998|UniProtKB=G5EG49	TFIIE-alpha protein	ISS			PTHR13097:SF7	NOVEL PROTEIN SIMILAR TO VERTEBRATE GENERAL TRANSCRIPTION FACTOR IIE POLYPEPTIDE 1 ALPHA 56KDA  GTF2E1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00025	Hedgehog signaling pathway	P00697	Sap18	CHICK|Ensembl=ENSGALG00000017129|UniProtKB=Q90ZH5	SAP18	ISS			PTHR13082:SF0	HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18
P00056	VEGF signaling pathway	P01409	cPLA2	DANRE|ZFIN=ZDB-GENE-990415-45|UniProtKB=P50392	Cytosolic phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04393	Ras Pathway	P04557	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00012	Cadherin signaling pathway	P00477	GSK3beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	RAT|RGD=2246|UniProtKB=Q07652	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	14624853	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00029	Huntington disease	P00785	Cytochrome c	CANLF|Ensembl=ENSCAFG00000001529|UniProtKB=E2REM0	Uncharacterized protein	ISS	9027315	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00775	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00018	EGF receptor signaling pathway	P00556	PLCgamma	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00006	Apoptosis signaling pathway	P00303	c-Jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00029	Huntington disease	P00811	Arp2/3 complex	MONDO|Ensembl=ENSMODG00000007194|UniProtKB=F6X9N6	Actin-related protein 2/3 complex subunit 5	ISS	9230079	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00022	General transcription by RNA polymerase I	P00657	TBP	DANRE|ZFIN=ZDB-GENE-030616-563|UniProtKB=Q7SXL3	TATA-box-binding protein	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000017256|UniProtKB=F7GWW5	Uncharacterized protein	ISS	18021322	PubMed	PTHR10037:SF137	VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1G
P00048	PI3 kinase pathway	P01181	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00005	Angiogenesis	P00249	PAK	CANLF|Ensembl=ENSCAFG00000004956|UniProtKB=E2REH3	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00034	Integrin signalling pathway	P00944	Actin	MOUSE|MGI=MGI=87906|UniProtKB=P63260	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	HUMAN|HGNC=1392|UniProtKB=Q15878	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	11976940	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00018	EGF receptor signaling pathway	P00539	14-3-3	DANRE|ZFIN=ZDB-GENE-050306-44|UniProtKB=Q5CZQ1	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2	ISS	8024705	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00057	Wnt signaling pathway	P01457	GBeta	EMENI|EnsemblGenome=CADANIAG00002670|UniProtKB=Q5BH99	G-protein beta subunit [Source:UniProtKB/TrEMBLAcc:O74214]	IDA	10523303	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00036	Interleukin signaling pathway	P00974	Receptor subunit beta	MOUSE|MGI=MGI=1270861|UniProtKB=P97378	Interleukin-12 receptor subunit beta-2	IDA	8943050	PubMed	PTHR23036:SF79	INTERLEUKIN-12 RECEPTOR SUBUNIT BETA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	BOVIN|Ensembl=ENSBTAG00000011579|UniProtKB=F1N5C5	Muscarinic acetylcholine receptor	ISS	11166329	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	HUMAN|HGNC=17780|UniProtKB=Q562R1	Beta-actin-like protein 2	IC	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	ORYSJ|EnsemblGenome=OS01G0510800|UniProtKB=Q8LRG9	Os01g0510800 protein	ISS	12447438	PubMed	PTHR10221:SF9	TAF6-LIKE RNA POLYMERASE II P300/CBP-ASSOCIATED FACTOR-ASSOCIATED FACTOR 65 KDA SUBUNIT 6L
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	CHICK|Ensembl=ENSGALG00000008512|UniProtKB=F1P0S6	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P04395	Vasopressin synthesis	P04593	Glycopeptide	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	IC	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00029	Huntington disease	P00805	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05972	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05731	GABA-B receptor II signaling	P05755	Gbeta	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	HUMAN|HGNC=6091|UniProtKB=P06213	Insulin receptor	ISS	14500580	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=88356|UniProtKB=P10287	Cadherin-3	IDA	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00046	Oxidative stress response	P01125	Stat1	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	15825084	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00036	Interleukin signaling pathway	P00985	PDK1/2	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	15210700	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00057	Wnt signaling pathway	P01444	Wnt	RAT|RGD=1306312|UniProtKB=D4A9D7	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P06587	Nicotine pharmacodynamics pathway	P06613	CHRNB2	MOUSE|MGI=MGI=87891|UniProtKB=Q9ERK7	Neuronal acetylcholine receptor subunit beta-2	ISS	22213672	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00019	Endothelin signaling pathway	P00586	Gq	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00007	Axon guidance mediated by semaphorins	P00331	PAK	RAT|RGD=3250|UniProtKB=P35465	Serine/threonine-protein kinase PAK 1	ISS	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00056	VEGF signaling pathway	P01407	Erk	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01305	Calmodulin	ARATH|TAIR=AT3G43810|UniProtKB=P59220	Calmodulin-7	ISS	10487978	PubMed	PTHR23050:SF250	CALMODULIN-7
P00053	T cell activation	P01324	rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	15470041	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT4G36450|UniProtKB=O23236	Mitogen-activated protein kinase 14	ISS	9836510	gi	PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IDA	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00012	Cadherin signaling pathway	P00475	Frizzled	HUMAN|HGNC=4043|UniProtKB=Q13467	Frizzled-5	IDA	11212302	PubMed	PTHR11309:SF126	FRIZZLED-5
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	TAS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	HUMAN|HGNC=4572|UniProtKB=P42262	Glutamate receptor 2	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00056	VEGF signaling pathway	P01403	VEGFR-2	HUMAN|HGNC=6307|UniProtKB=P35968	Vascular endothelial growth factor receptor 2	IDA	11221852	PubMed	PTHR24416:SF45	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05918	p38 MAPK pathway	P06020	p38delta	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	12810719	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=1913316|UniProtKB=P61953	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	ISS			PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00005	Angiogenesis	P00238	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04371	5-Hydroxytryptamine biosynthesis	P04399	Tryptophan hydroxylase	MOUSE|MGI=MGI=2651811|UniProtKB=Q8CGV2	Tryptophan 5-hydroxylase 2	ISS	14597720	PubMed	PTHR11473:SF16	TRYPTOPHAN 5-HYDROXYLASE 2
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	RAT|RGD=708450|UniProtKB=Q9Z286	Adenylate cyclase type 10	IGI	9874775	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P00021	FGF signaling pathway	P00632	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IGI	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	RCA			PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT1G18150|UniProtKB=Q9LM33	Mitogen-activated protein kinase 8	ISS	15220976	gi	PTHR24055:SF246	MITOGEN-ACTIVATED PROTEIN KINASE 15-RELATED
P00057	Wnt signaling pathway	P01443	Phospholipase C	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00046	Oxidative stress response	P01135	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	DICDI|dictyBase=DDB_G0292998|UniProtKB=P32252	Ras-like protein rasB	ISS	93205383	PubMed	PTHR24070:SF206	RAS-LIKE PROTEIN RASB
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00010	B cell activation	P00373	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IGI	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	XENTR|Xenbase=XB-GENE-480347|UniProtKB=Q6P640	Actin, alpha cardiac muscle 1	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	CAEEL|WormBase=WBGene00000295|UniProtKB=Q9GNP0	Uncharacterized protein	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=18539|UniProtKB=P61266	Syntaxin-1B	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	SCHPO|PomBase=SPBC26H8.07c|UniProtKB=P05219	Tubulin beta chain	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	MOUSE|MGI=MGI=1347078|UniProtKB=O70293	G protein-coupled receptor kinase 6	RCA			PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=2446084|UniProtKB=Q8R5M2	Protein Wnt-9a	IDA	11266476	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P00034	Integrin signalling pathway	P00924	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000006342|UniProtKB=H2Q8A8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04393	Ras Pathway	P04541	p90RSK	CHICK|Ensembl=ENSGALG00000011473|UniProtKB=F1P1H2	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CAEEL|WormBase=WBGene00003774|UniProtKB=G5EGQ9	NMDA class glutamate Receptor	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PRIPA|Gene=PPA17339|UniProtKB=H3F5B4	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF352	ACTIN
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MACMU|Ensembl=ENSMMUG00000006621|UniProtKB=F7HKD3	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00048	PI3 kinase pathway	P01181	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P06959	CCKR signaling map	P07085	RAF1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	RCA	9069260	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	ARATH|TAIR=AT3G55630|UniProtKB=Q8W035	Folylpolyglutamate synthase	ISS			PTHR11136:SF5	FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL
P00053	T cell activation	P01322	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	ANOGA|EnsemblGenome=AGAP001394|UniProtKB=F5HMS4	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00012	Cadherin signaling pathway	P00477	GSK3beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MOUSE|MGI=MGI=87909|UniProtKB=P62737	Actin, aortic smooth muscle	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00005	Angiogenesis	P00219	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	IDA	10556059	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MOUSE|MGI=MGI=894644|UniProtKB=Q8CC27	Voltage-dependent L-type calcium channel subunit beta-2	IC	20088160	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	XENTR|Xenbase=XB-GENE-923233|UniProtKB=Q6AZK9	Nucleoside diphosphate kinase	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05916	Opioid prodynorphin pathway	P05999	provasopressin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	PANTR|Gene=CXCR1|UniProtKB=P55920	C-X-C chemokine receptor type 1	ISS	6753456	gi	PTHR10489:SF916	C-X-C CHEMOKINE RECEPTOR TYPE 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00566	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00715	AGS3	BOVIN|Ensembl=ENSBTAG00000018799|UniProtKB=G3N266	Uncharacterized protein	ISS	11121039	PubMed	PTHR10098:SF36	G-PROTEIN-SIGNALING MODULATOR 1
P00046	Oxidative stress response	P01135	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	TAS	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04452	proopiomelanocortin	RAT|RGD=3366|UniProtKB=P01194	Pro-opiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00010	B cell activation	P00386	Calcineurin	HUMAN|HGNC=9314|UniProtKB=Q08209	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	IDA	7532676	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04578	Rho	BOVIN|Ensembl=ENSBTAG00000004279|UniProtKB=P61585	Transforming protein RhoA	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00029	Huntington disease	P00808	Caspase 8	PANTR|Ensembl=ENSPTRG00000012801|UniProtKB=H2QJ86	Caspase 8, apoptosis-related cysteine peptidase	ISS	8681376	PubMed	PTHR10454:SF162	CASPASE-8
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	RAT|RGD=620761|UniProtKB=Q9R172	Neurogenic locus notch homolog protein 3	IDA	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00021	FGF signaling pathway	P00626	Spry	MOUSE|MGI=MGI=1345138|UniProtKB=Q9QXV8	Protein sprouty homolog 2	IGI	12225946	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	HUMAN|HGNC=1338|UniProtKB=P21730	C5a anaphylatoxin chemotactic receptor 1	IDA	10352266	PubMed	PTHR24225:SF29	C5A ANAPHYLATOXIN CHEMOTACTIC RECEPTOR 1
P00046	Oxidative stress response	P01134	cPLA2	PANTR|Ensembl=ENSPTRG00000001787|UniProtKB=H2Q0T0	Phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P02754	Methylcitrate cycle	P03028	Aconitase	MACMU|Ensembl=ENSMMUG00000023474|UniProtKB=F7E7R2	Uncharacterized protein	ISS			PTHR11670:SF31	IRON-RESPONSIVE ELEMENT-BINDING PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	IDA	12040174	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00005	Angiogenesis	P00200	Dsh	HUMAN|HGNC=3084|UniProtKB=O14640	Segment polarity protein dishevelled homolog DVL-1	IDA	12549854	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P02738	De novo purine biosynthesis	P02901	Adenosuccinate lyase	PANTR|Ensembl=ENSPTRG00000014407|UniProtKB=H2QLR3	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00046	Oxidative stress response	P01128	MEF-2	MONDO|Ensembl=ENSMODG00000020223|UniProtKB=F7FXI4	Uncharacterized protein	ISS	11274345	PubMed	PTHR11945:SF25	MYOCYTE-SPECIFIC ENHANCER FACTOR 2C
P00019	Endothelin signaling pathway	P00577	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	IGI	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	CAEEL|WormBase=WBGene00010924|UniProtKB=Q21544	Uncharacterized protein	ISS			PTHR11645:SF46	PYRROLINE-5-CARBOXYLATE REDUCTASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00010	B cell activation	P00401	jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	HUMAN|HGNC=11641|UniProtKB=Q9NQB0	Transcription factor 7-like 2	TAS	11266476	PubMed	PTHR10373:SF32	TRANSCRIPTION FACTOR 7-LIKE 2
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	MOUSE|MGI=MGI=94926|UniProtKB=P51436	D(4) dopamine receptor	ISS	1319557	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01375	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00054	Toll receptor signaling pathway	P01375	JNK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00045	Notch signaling pathway	P01100	CoA	YEAST|SGD=S000003484|UniProtKB=Q03330	Histone acetyltransferase GCN5	TAS	11112321	PubMed	PTHR22880:SF137	NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	RAT|RGD=619966|UniProtKB=F1LQT1	Adenylate cyclase 7	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P05916	Opioid prodynorphin pathway	P06002	G-protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P06959	CCKR signaling map	P07019	RHOA-GDP	HUMAN|HGNC=667|UniProtKB=P61586	Transforming protein RhoA	RCA	12105855	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	PANTR|Gene=CHRM2|UniProtKB=Q9N2A7	Muscarinic acetylcholine receptor M2 (Fragment)	ISS	11166329	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00036	Interleukin signaling pathway	P00990	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=109356|UniProtKB=O09044	Synaptosomal-associated protein 23	IC	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	BRAFL|Gene=BRAFLDRAFT_128184|UniProtKB=C4A0B6	Tyrosine-protein kinase receptor	ISS	249616	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P02723	Adenine and hypoxanthine salvage pathway	P02810	Adenine phosphoribosyl transferase	BOVIN|Ensembl=ENSBTAG00000000639|UniProtKB=Q56JW4	Adenine phosphoribosyltransferase	ISS			PTHR32315:SF3	ADENINE PHOSPHORIBOSYLTRANSFERASE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	RAT|RGD=2733|UniProtKB=P42260	Glutamate receptor ionotropic, kainate 2	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CAEBR|Gene=CBG17587|UniProtKB=A8XRA5	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	DANRE|ZFIN=ZDB-GENE-980526-87|UniProtKB=Q92050	Protein Wnt-5b	TAS	8717036	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00012	Cadherin signaling pathway	P00470	F-actin	XENTR|Xenbase=XB-GENE-491938|UniProtKB=Q6DIV8	Actin, alpha 1, skeletal muscle	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MACMU|Ensembl=ENSMMUG00000011015|UniProtKB=F7GQW5	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF115	MATRIX METALLOPROTEINASE-27
P05731	GABA-B receptor II signaling	P05755	Gbeta	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00029	Huntington disease	P00778	NMDA receptor	BOVIN|Ensembl=ENSBTAG00000047202|UniProtKB=G3N3K3	Uncharacterized protein	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	XENTR|Xenbase=XB-GENE-969601|UniProtKB=Q28H40	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00036	Interleukin signaling pathway	P00972	MNK1/2	MOUSE|MGI=MGI=894316|UniProtKB=O08605	MAP kinase-interacting serine/threonine-protein kinase 1	IC	9155017	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MOUSE|MGI=MGI=87905|UniProtKB=P68033	Actin, alpha cardiac muscle 1	IC	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	HUMAN|HGNC=143|UniProtKB=P68032	Actin, alpha cardiac muscle 1	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P02785	Valine biosynthesis	P03218	Dihydroxy isovalerate dehydratase	ECOLI|EcoGene=EG12549|UniProtKB=P39358	Uncharacterized protein YjhG	ISS			PTHR43661:SF2	SUBFAMILY NOT NAMED
P05731	GABA-B receptor II signaling	P05754	Ggamma	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	RCA	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00029	Huntington disease	P00790	beta-Tubulin	XENTR|Xenbase=XB-GENE-6259095|UniProtKB=Q5BL39	Tubulin, beta 2	ISS	9454836	PubMed	PTHR11588:SF93	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00035	Interferon-gamma signaling pathway	P00960	PTP	PANTR|Ensembl=ENSPTRG00000042397|UniProtKB=H2RIH8	Tyrosine-protein phosphatase non-receptor type	ISS	8096088	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00018	EGF receptor signaling pathway	P00564	Rac	DROME|FlyBase=FBgn0014011|UniProtKB=P48554	Ras-related protein Rac2	ISS	12932731	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P02748	Isoleucine biosynthesis	P02998	Dihydroxyacid dehydratase	LEPIN|EnsemblGenome=LA_2959|UniProtKB=Q8F219	Dihydroxy-acid dehydratase	ISS			PTHR21000:SF5	DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00021	FGF signaling pathway	P00629	PP2A	CHICK|Ensembl=ENSGALG00000015531|UniProtKB=E1C2X1	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B	ISS	7918404	PubMed	PTHR11871:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B GAMMA ISOFORM
P00029	Huntington disease	P00776	c-Jun	CHICK|Gene=JUN|UniProtKB=P18870	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	MONDO|Ensembl=ENSMODG00000014177|UniProtKB=F6U7A6	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05755	Gbeta	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	CANLF|Ensembl=ENSCAFG00000003415|UniProtKB=E2R8D9	Uncharacterized protein	ISS			PTHR11482:SF42	ORNITHINE DECARBOXYLASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01173	STAT	MONDO|Ensembl=ENSMODG00000014816|UniProtKB=F7CHH2	Signal transducer and activator of transcription	ISS	22320921	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P04393	Ras Pathway	P04559	Rac	CHICK|Ensembl=ENSGALG00000002859|UniProtKB=F6UBD2	Uncharacterized protein	ISS	9252344	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PANTR|Ensembl=ENSPTRG00000006890|UniProtKB=H2Q943	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P05918	p38 MAPK pathway	P06013	ELK	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	RCA	11050086	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00005	Angiogenesis	P00221	JNK1	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00045	Notch signaling pathway	P01115	Neurotic	CHICK|Ensembl=ENSGALG00000008078|UniProtKB=E1BUM7	Alpha-(1,6)-fucosyltransferase	ISS			PTHR13132:SF29	ALPHA- 1,6 -FUCOSYLTRANSFERASE
P00057	Wnt signaling pathway	P01444	Wnt	MACMU|Ensembl=ENSMMUG00000007765|UniProtKB=F7CW57	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00018	EGF receptor signaling pathway	P00551	Akt	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	IGI	9716402	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00059	p53 pathway	P01486	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01181	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IDA	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04393	Ras Pathway	P04557	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MOUSE|MGI=MGI=1915201|UniProtKB=Q922F4	Tubulin beta-6 chain	ISS	9454836	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00047	PDGF signaling pathway	P01142	p90RSK	HUMAN|HGNC=10432|UniProtKB=P51812	Ribosomal protein S6 kinase alpha-3	ISS	6755374	gi	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00006	Apoptosis signaling pathway	P00274	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00052	TGF-beta signaling pathway	P01275	P38	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	4506785	gi	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P05734	Synaptic vesicle trafficking	P05775	Synapsin	MOUSE|MGI=MGI=98460|UniProtKB=O88935	Synapsin-1	TAS	15265868	PubMed	PTHR10841:SF22	SYNAPSIN-1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	TAS	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P06664	Gonadotropin-releasing hormone receptor pathway	P06834	MAP3Ks	MOUSE|MGI=MGI=1346874|UniProtKB=Q61084	Mitogen-activated protein kinase kinase kinase 3	RCA	11730323	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P02781	Threonine biosynthesis	P03190	Threonine synthase	PSEAE|EnsemblGenome=PA3735|UniProtKB=P29363	Threonine synthase	ISS	10984043	PubMed	PTHR42690:SF1	THREONINE SYNTHASE-LIKE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00047	PDGF signaling pathway	P01142	p90RSK	DROME|FlyBase=FBgn0262866|UniProtKB=Q9VR61	Ribosomal protein S6 kinase II, isoform A	ISS	6755374	gi	PTHR24351:SF110	RIBOSOMAL PROTEIN S6 KINASE II, ISOFORM A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	TAS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	PANTR|Ensembl=ENSPTRG00000014910|UniProtKB=H2QMK8	Glutaminyl-tRNA synthetase	ISS			PTHR43097:SF1	GLUTAMINE--TRNA LIGASE
P00049	Parkinson disease	P01211	ERK	ORYSJ|EnsemblGenome=OS06G0699400|UniProtKB=Q5Z859	Mitogen-activated protein kinase 4	IDA	11707292	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00029	Huntington disease	P00777	CBP	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00047	PDGF signaling pathway	P01161	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04567	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00591	PLCbeta	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00053	T cell activation	P01305	Calmodulin	MONDO|Ensembl=ENSMODG00000004410|UniProtKB=F6SV58	Uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF322	SUBFAMILY NOT NAMED
P05912	Dopamine receptor mediated signaling pathway	P05968	CLIC6	HUMAN|HGNC=2065|UniProtKB=Q96NY7	Chloride intracellular channel protein 6	ISS	14499480	PubMed	PTHR45476:SF1	CHLORIDE INTRACELLULAR CHANNEL PROTEIN 6
P05915	Opioid proenkephalin pathway	P05989	leu-Enkephalin	DANRE|ZFIN=ZDB-GENE-030729-31|UniProtKB=A8E7S2	Uncharacterized protein	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P04393	Ras Pathway	P04572	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00557	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04564	MAPKAP	MOUSE|MGI=MGI=109298|UniProtKB=P49138	MAP kinase-activated protein kinase 2	IDA	8262198	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	TAS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00048	PI3 kinase pathway	P01182	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00059	p53 pathway	P04633	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00626	Spry	HUMAN|HGNC=15533|UniProtKB=Q9C004	Protein sprouty homolog 4	ISS	10330503	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P00021	FGF signaling pathway	P00631	Grb2	CAEEL|WormBase=WBGene00004774|UniProtKB=P29355	Sex muscle abnormal protein 5	IPI	11457149	PubMed	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04393	Ras Pathway	P04572	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02787	Vitamin B6 metabolism	P03227	Phosphoserine transaminase	MOUSE|MGI=MGI=2183441|UniProtKB=Q99K85	Phosphoserine aminotransferase	TAS	20886743	gi	PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P05913	Enkephalin release	P05974	G-Protein (i)	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	XENTR|Xenbase=XB-GENE-967585|UniProtKB=Q28BZ0	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00269	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01332	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MONDO|Ensembl=ENSMODG00000009983|UniProtKB=F6USY2	Uncharacterized protein	ISS	8649450	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00056	VEGF signaling pathway	P01414	PLC-gamma	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CANLF|Ensembl=ENSCAFG00000032632|UniProtKB=J9P2Q5	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P02766	Phenylethylamine degradation	P03103	Phenylethylamine oxidase	ARATH|TAIR=AT4G12280|UniProtKB=Q9STI3	Amine oxidase	ISS			PTHR10638:SF41	AMINE OXIDASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00543	ERK1-2	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	IGI	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DANRE|ZFIN=ZDB-GENE-000329-3|UniProtKB=Q7ZVF9	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00060	Ubiquitin proteasome pathway	P01491	E2	PLAF7|EnsemblGenome=PFC0855w|UniProtKB=O77397	Ubiquitin-conjugating enzyme, putative	ISS			PTHR43898:SF1	UBIQUITIN-CONJUGATING ENZYME E2-17 KDA
P02748	Isoleucine biosynthesis	P02995	Threonine dehydratase	STRCO|Gene=CAB48898|UniProtKB=Q9XAA4	Putative threonine dehydratase	ISS			PTHR43050:SF1	SERINE RACEMASE
P00060	Ubiquitin proteasome pathway	P01491	E2	BOVIN|Gene=UBE2D3|UniProtKB=Q3ZCF7	Ubiquitin-conjugating enzyme E2 D3	ISS			PTHR24068:SF48	UBIQUITIN-CONJUGATING ENZYME E2 D3
P00012	Cadherin signaling pathway	P00474	Wnt	RAT|RGD=1562253|UniProtKB=D4A3K6	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	TAS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00007	Axon guidance mediated by semaphorins	P00339	CRMP	MACMU|Ensembl=ENSMMUG00000012718|UniProtKB=F7DF35	Uncharacterized protein	ISS	Q90635	SPACC	PTHR11647:SF56	DIHYDROPYRIMIDINASE-RELATED PROTEIN 2
P06959	CCKR signaling map	P07228	MAPK1/3	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	RCA	12184814	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00397	IKK	MOUSE|MGI=MGI=99484|UniProtKB=Q60680	Inhibitor of nuclear factor kappa-B kinase subunit alpha	IGI	9346484	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01173	STAT	MONDO|Ensembl=ENSMODG00000014816|UniProtKB=F7CHH2	Signal transducer and activator of transcription	ISS	96210005	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	MACMU|Ensembl=ENSMMUG00000012470|UniProtKB=F7G0B2	Uncharacterized protein	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00034	Integrin signalling pathway	P00925	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=1310903|UniProtKB=D4A978	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF33	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-3
P00048	PI3 kinase pathway	P01181	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04393	Ras Pathway	P04550	Ral	DROME|FlyBase=FBgn0015286|UniProtKB=P48555	Ras-related protein Ral-a	ISS			PTHR24070:SF258	RAS-RELATED PROTEIN RAL-A
P04393	Ras Pathway	P04552	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00044	Nicotinic acetylcholine receptor signaling pathway	P01094	gamma	BOVIN|Ensembl=ENSBTAG00000045943|UniProtKB=P13536	Acetylcholine receptor subunit gamma	ISS	95224005	PubMed	PTHR18945:SF60	ACETYLCHOLINE RECEPTOR SUBUNIT GAMMA
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00036	Interleukin signaling pathway	P00973	PKB	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00046	Oxidative stress response	P01131	MKP5	CAEBR|Gene=CBG00285|UniProtKB=A8WML9	Protein CBG00285	ISS			PTHR10159:SF492	SUBFAMILY NOT NAMED
P00025	Hedgehog signaling pathway	P00682	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01444	Wnt	PANTR|Ensembl=ENSPTRG00000004893|UniProtKB=H2Q5U4	Protein Wnt	ISS	14644163	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00006	Apoptosis signaling pathway	P00260	AKT	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	ISS	98382502	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	ISS	14526383	PubMed	PTHR10048:SF14	PI-3 KINASE
P02779	Thiamin biosynthesis	P03173	Thiamin phosphate synthase	FUSNN|EnsemblGenome=FN1758|UniProtKB=Q8RI59	Thiamine-phosphate synthase	ISS			PTHR20857:SF15	THIAMINE BIOSYNTHETIC BIFUNCTIONAL ENZYME
P00047	PDGF signaling pathway	P01160	IP3 receptor	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00029	Huntington disease	P00807	Actin	CHICK|Ensembl=ENSGALG00000011086|UniProtKB=P68139	Actin, alpha skeletal muscle	ISS	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00049	Parkinson disease	P01237	Complex I	PSEAE|EnsemblGenome=PA2640|UniProtKB=Q9I0J8	NADH-quinone oxidoreductase subunit E	TAS	3100899	PubMed	PTHR10371:SF3	NADH DEHYDROGENASE  UBIQUINONE  FLAVOPROTEIN 2, MITOCHONDRIAL
P00060	Ubiquitin proteasome pathway	P01492	E1	MOUSE|MGI=MGI=1341217|UniProtKB=Q8C878	NEDD8-activating enzyme E1 catalytic subunit	ISS			PTHR10953:SF6	NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT
P00052	TGF-beta signaling pathway	P01275	P38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00005	Angiogenesis	P00243	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00057	Wnt signaling pathway	P01432	Beta-Catenin	MOUSE|MGI=MGI=88276|UniProtKB=Q02248	Catenin beta-1	IDA	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MOUSE|MGI=MGI=1928375|UniProtKB=Q9JM76	Actin-related protein 2/3 complex subunit 3	ISS	12473693	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	IDA	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00556	PLCgamma	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00554	Shc	MOUSE|MGI=MGI=106179|UniProtKB=Q61120	SHC-transforming protein 3	IGI	12006576	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00050	Plasminogen activating cascade	P01253	Fibrin	XENTR|Xenbase=XB-GENE-483216|UniProtKB=B0JZ09	Fgb protein	ISS	1160337	gi	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05915	Opioid proenkephalin pathway	P05994	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00019	Endothelin signaling pathway	P00570	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	SCHPO|PomBase=SPBC2G5.02c|UniProtKB=O94281	Probable casein kinase II subunit beta-2	IDA	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00057	Wnt signaling pathway	P01440	Cadherin	BOVIN|Ensembl=ENSBTAG00000018179|UniProtKB=F1MEC8	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF46	PROTOCADHERIN-8
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00012	Cadherin signaling pathway	P00467	alpha-catenin	PANTR|Ensembl=ENSPTRG00000017291|UniProtKB=H2QRK9	Catenin (Cadherin-associated protein), alpha 1, 102kDa	ISS	1904011	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IC	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	TAKRU|Ensembl=ENSTRUG00000010005|UniProtKB=H2TKG8	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	NEUCR|EnsemblGenome=EFNCRG00000004240|UniProtKB=Q01386	cAMP-dependent protein kinase regulatory subunit	IC	2372396	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	IDA	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00012	Cadherin signaling pathway	P00470	F-actin	MOUSE|MGI=MGI=87906|UniProtKB=P63260	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02749	Leucine biosynthesis	P03000	Branched chain amino acid aminotransferase	STRCO|EnsemblGenome=CAA19971|UniProtKB=O86505	Probable branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF44	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00004	Alzheimer disease-presenilin pathway	P00172	BACE-1	MONDO|Ensembl=ENSMODG00000013692|UniProtKB=F6QP52	Uncharacterized protein	ISS	10531052	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	PANTR|Ensembl=ENSPTRG00000031262|UniProtKB=H2RAB4	Uncharacterized protein	ISS	15328036	PubMed	PTHR43893:SF8	D 1B  DOPAMINE RECEPTOR
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01084	CHT1	HUMAN|HGNC=14025|UniProtKB=Q9GZV3	High affinity choline transporter 1	RCA			PTHR11819:SF129	HIGH AFFINITY CHOLINE TRANSPORTER 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00018	EGF receptor signaling pathway	P00547	PP2A	ANOGA|EnsemblGenome=AGAP010172|UniProtKB=Q7PD38	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=3234|UniProtKB=P33535	Mu-type opioid receptor	IDA	12093103	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00022	General transcription by RNA polymerase I	P00651	TAF-IA	SCHPO|PomBase=SPCC1259.06|UniProtKB=O94706	Transcription initiation factor TFIID subunit 8	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IDA	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P02774	Salvage pyrimidine deoxyribonucleotides	P03145	Uracil phosphorylase	ECOLI|EcoGene=EG10219|UniProtKB=P07650	Thymidine phosphorylase	ISS	9278503	PubMed	PTHR10515:SF0	THYMIDINE PHOSPHORYLASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	TAS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	RAT|RGD=621060|UniProtKB=O88777	Presenilin-2	TAS	9332390	PubMed	PTHR10202:SF13	PRESENILIN-2
P00029	Huntington disease	P00796	Kainate receptor	TAKRU|Ensembl=ENSTRUG00000009259|UniProtKB=H2TF39	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PHYPA|Gene=PHYPADRAFT_232451|UniProtKB=A9SKU2	Predicted protein	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00048	PI3 kinase pathway	P01198	FOXO	BOVIN|Ensembl=ENSBTAG00000011234|UniProtKB=F1N4K5	Uncharacterized protein	ISS	12884295	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00049	Parkinson disease	P01230	Src kinase	CHICK|Ensembl=ENSGALG00000014860|UniProtKB=P09324	Tyrosine-protein kinase Yes	IDA	11078745	PubMed	PTHR24418:SF90	TYROSINE-PROTEIN KINASE YES
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00025	Hedgehog signaling pathway	P00692	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	IC	1319556	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00048	PI3 kinase pathway	P01199	Galpha	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00045	Notch signaling pathway	P01104	Serrate	CHICK|Ensembl=ENSGALG00000011696|UniProtKB=F1NMD6	Delta-like protein	IEP	9032054	PubMed	PTHR44097:SF1	PROTEIN JAGGED-2
P00053	T cell activation	P01332	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02730	Asparagine and aspartate biosynthesis	P02853	Asparagine synthetase	CAEEL|WormBase=WBGene00019730|UniProtKB=Q21463	Asparagine synthetase	ISS			PTHR11772:SF2	ASPARAGINE SYNTHETASE
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=1310389|UniProtKB=D3ZTF6	Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Predicted), isoform CRA_a	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00052	TGF-beta signaling pathway	P01286	TGFbeta	RAT|RGD=1306120|UniProtKB=D3Z8U5	Metalloendopeptidase	ISS	9759503	PubMed	PTHR43978:SF4	TOLLOID-LIKE PROTEIN 1
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	CANLF|Ensembl=ENSCAFG00000003995|UniProtKB=E2RC09	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00057	Wnt signaling pathway	P01435	SWI/SNF	CAEBR|Gene=CBG09873|UniProtKB=A8X9V3	Protein CBR-SWSN-2.1	ISS	11532957	PubMed	PTHR13844:SF7	BRAHMA-ASSOCIATED PROTEIN OF 60 KDA
P00021	FGF signaling pathway	P00627	ERK1-2	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00021	FGF signaling pathway	P00642	MEK1-2	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00011	Blood coagulation	P00429	PN2	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	ISS	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00010	B cell activation	P00396	CD45	CHICK|Ensembl=ENSGALG00000002192|UniProtKB=F1NVB1	Uncharacterized protein	IGI	1672451	PubMed	PTHR19134:SF284	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00018	EGF receptor signaling pathway	P00560	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00047	PDGF signaling pathway	P01171	PLCgamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	IC	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00936	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IPI	10799299	PubMed	PTHR10048:SF14	PI-3 KINASE
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	HUMAN|HGNC=20776|UniProtKB=Q9BUF5	Tubulin beta-6 chain	ISS	9454836	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00640	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02738	De novo purine biosynthesis	P02902	ADP reductase	CAEEL|WormBase=WBGene00017610|UniProtKB=Q19599	Uncharacterized protein	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	ANOGA|Gene=AgaP_AGAP009115|UniProtKB=Q7PW25	Phosphoinositide phospholipase C (Fragment)	ISS	10934033	PubMed	PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	SCHPO|PomBase=SPAC1851.03|UniProtKB=P40232	Casein kinase II subunit beta	IDA	10806215	PubMed	PTHR11740:SF13	CASEIN KINASE II SUBUNIT BETA'
P04393	Ras Pathway	P04552	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MOUSE|MGI=MGI=88398|UniProtKB=Q9ERZ3	Muscarinic acetylcholine receptor M3	TAS	8100450	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01177	P110ACT	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00243	Raf	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00019	Endothelin signaling pathway	P00586	Gq	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	BOVIN|Ensembl=ENSBTAG00000001332|UniProtKB=Q27966	Unconventional myosin-Ic	IC			PTHR13140:SF255	UNCONVENTIONAL MYOSIN-IC
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05728	Anandamide degradation	P05741	FAAH	HUMAN|HGNC=3553|UniProtKB=O00519	Fatty-acid amide hydrolase 1	IDA	12060782	PubMed	PTHR11895:SF91	FATTY-ACID AMIDE HYDROLASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000001384|UniProtKB=F7GL73	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CAEBR|Gene=CBG05858|UniProtKB=A8X1H0	Protein CBR-EGL-19 (Fragment)	ISS	10514528	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	METAC|EnsemblGenome=MA_2143|UniProtKB=Q8TNY4	Carbamoyl-phosphate synthase large chain	ISS			PTHR11405:SF5	CAD PROTEIN
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	SCHMA|EnsemblGenome=Smp_020170|UniProtKB=G4V8E3	Voltage-dependent calcium channel (Fragment)	ISS	14624853	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P00047	PDGF signaling pathway	P01171	PLCgamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000011842|UniProtKB=G7NAM7	Uncharacterized protein	ISS	6323229	PubMed	PTHR24248:SF26	ALPHA-2B ADRENERGIC RECEPTOR
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	ORNAN|Ensembl=ENSOANG00000004061|UniProtKB=F6TYN8	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00034	Integrin signalling pathway	P00931	Integrin beta	RAT|RGD=2927|UniProtKB=P49134	Integrin beta-1	IDA	10706722	PubMed	PTHR10082:SF28	INTEGRIN BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	DANRE|ZFIN=ZDB-GENE-990415-257|UniProtKB=O42376	Mitogen-activated protein kinase 12	ISS	10851062	PubMed	PTHR24055:SF339	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00018	EGF receptor signaling pathway	P00543	ERK1-2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	IDA	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00582	COX-2	XENTR|Xenbase=XB-GENE-482133|UniProtKB=Q501R2	Prostaglandin-endoperoxide synthase 2 (Prostaglandin G/H synthase and cyclooxygenase)	ISS			PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=1305171|UniProtKB=G3V8P1	Protein Pcdhb3	ISS	8120095	PubMed	PTHR24028:SF118	PROTOCADHERIN BETA-3
P00053	T cell activation	P01322	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MOUSE|MGI=MGI=99675|UniProtKB=Q8VHH7	Adenylate cyclase type 3	IDA	2255909	PubMed	PTHR11920:SF291	ADENYLATE CYCLASE TYPE 3
P00034	Integrin signalling pathway	P00922	Collagen	MACMU|Ensembl=ENSMMUG00000021290|UniProtKB=F6V6S9	Uncharacterized protein	ISS	10778855	PubMed	PTHR24023:SF539	COLLAGEN ALPHA-2 V  CHAIN
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P06959	CCKR signaling map	G07285	ACAT1	HUMAN|HGNC=93|UniProtKB=P24752	Acetyl-CoA acetyltransferase, mitochondrial	RCA	19502590	PubMed	PTHR18919:SF81	ACETYL-COA ACETYLTRANSFERASE, MITOCHONDRIAL
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	12810719	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00021	FGF signaling pathway	P00632	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	SCLS1|EnsemblGenome=SS1G_03482|UniProtKB=A7EDU2	Guanine nucleotide-binding protein beta subunit	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00057	Wnt signaling pathway	P01443	Phospholipase C	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IDA	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	CAEEL|WormBase=WBGene00002783|UniProtKB=O44743	Uncharacterized protein	ISS			PTHR22952:SF367	ATF6, ISOFORM C
P00017	DNA replication	P00533	Pol delta	MACMU|Ensembl=ENSMMUG00000002423|UniProtKB=F6PLY1	DNA polymerase delta subunit 2	ISS	12522211	PubMed	PTHR10416:SF0	DNA POLYMERASE DELTA SUBUNIT 2
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00586	Gq	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04393	Ras Pathway	P04558	p38	TAKRU|Ensembl=ENSTRUG00000008723|UniProtKB=H2TB66	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF331	SUBFAMILY NOT NAMED
P00012	Cadherin signaling pathway	P00470	F-actin	ARATH|TAIR=AT5G09810|UniProtKB=P53492	Actin-7	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05923	beta-ARR2	MOUSE|MGI=MGI=99474|UniProtKB=Q91YI4	Beta-arrestin-2	RCA	11742073	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01199	Galpha	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	RAT|RGD=62029|UniProtKB=P02563	Myosin-6	ISS	89264452	PubMed	PTHR13140:SF721	MYOSIN-6
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	PANTR|Ensembl=ENSPTRG00000020481|UniProtKB=H2QWI9	Ribonucleotide reductase M2 B (TP53 inducible)	ISS			PTHR23409:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 B
P00047	PDGF signaling pathway	P01160	IP3 receptor	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04398	p53 pathway feedback loops 2	P04668	p53	CHICK|Ensembl=ENSGALG00000007324|UniProtKB=F1N8Z7	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00036	Interleukin signaling pathway	P00965	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	IC	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Gene=ACTA2|UniProtKB=P08023	Actin, aortic smooth muscle	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=101948|UniProtKB=P48615	Protein Wnt-11	IDA	11266476	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00057	Wnt signaling pathway	P01432	Beta-Catenin	RAT|RGD=70487|UniProtKB=Q9WU82	Catenin beta-1	IDA	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00034	Integrin signalling pathway	P00922	Collagen	PANTR|Ensembl=ENSPTRG00000006031|UniProtKB=H2Q7S9	Uncharacterized protein	ISS	10778855	PubMed	PTHR24023:SF854	COLLAGEN ALPHA-1 IV  CHAIN
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00005	Angiogenesis	P00238	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00021	FGF signaling pathway	P00628	JNK1-3	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IGI	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00010	B cell activation	P00383	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05730	Endogenous cannabinoid signaling	P05748	mGluR	RAT|RGD=2746|UniProtKB=P31424	Metabotropic glutamate receptor 5	ISS	92317054	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	CHICK|Ensembl=ENSGALG00000009320|UniProtKB=Q4JIM4	Presenilin-1	IDA	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	HUMAN|HGNC=4404|UniProtKB=P59768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00059	p53 pathway	P04612	HDAC1	XENTR|Xenbase=XB-GENE-479583|UniProtKB=F6ULG8	Histone deacetylase	ISS	10485845	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	G06896	Isl-1	MOUSE|MGI=MGI=101791|UniProtKB=P61372	Insulin gene enhancer protein ISL-1	RCA			PTHR24204:SF3	INSULIN GENE ENHANCER PROTEIN ISL-1
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	HUMAN|HGNC=4595|UniProtKB=Q14832	Metabotropic glutamate receptor 3	ISS	12488551	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00053	T cell activation	P01336	Jnk	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00059	p53 pathway	G04694	p110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00050	Plasminogen activating cascade	P01245	PAI-1	MOUSE|MGI=MGI=97608|UniProtKB=P22777	Plasminogen activator inhibitor 1	ISS	10692390	PubMed	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00543	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	21071228	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02750	Lipoate_biosynthesis	P03004	Lipoate synthase	ECOLI|EcoGene=EG11306|UniProtKB=P60716	Lipoyl synthase	ISS			PTHR10949:SF24	LIPOYL SYNTHASE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00047	PDGF signaling pathway	P01168	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05913	Enkephalin release	P05976	Enkephalin	DANRE|ZFIN=ZDB-GENE-030729-31|UniProtKB=A8E7S2	Uncharacterized protein	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P02748	Isoleucine biosynthesis	P02994	Branched chain amino acid aminotransferase	MOUSE|MGI=MGI=1276534|UniProtKB=O35855	Branched-chain-amino-acid aminotransferase, mitochondrial	ISS			PTHR11825:SF39	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, MITOCHONDRIAL
P00017	DNA replication	P00533	Pol delta	ORYSJ|EnsemblGenome=OS03G0128500|UniProtKB=Q9LRE5	DNA polymerase delta small subunit	NAS	13431489	gi	PTHR10416:SF0	DNA POLYMERASE DELTA SUBUNIT 2
P00005	Angiogenesis	P00191	TF	RAT|RGD=2587|UniProtKB=P42533	Tissue factor	ISS	6978823	gi	PTHR20859:SF22	TISSUE FACTOR
P00038	JAK/STAT signaling pathway	P01027	STAT	HUMAN|HGNC=11367|UniProtKB=P51692	Signal transducer and activator of transcription 5B	ISS	96210005	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00051	TCA cycle	P01268	Aconitase	YEAST|SGD=S000004295|UniProtKB=P19414	Aconitate hydratase, mitochondrial	RCA			PTHR43160:SF3	ACONITATE HYDRATASE, MITOCHONDRIAL
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1712|UniProtKB=Q6PBY0	Guanine nucleotide binding protein (G protein), beta 5	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	PANTR|Ensembl=ENSPTRG00000019449|UniProtKB=H2QV01	Actin related protein 2/3 complex, subunit 1B, 41kDa	ISS	9618202	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00006	Apoptosis signaling pathway	P00321	HSP70	MACMU|Ensembl=ENSMMUG00000005217|UniProtKB=F7C3R1	78 kDa glucose-regulated protein	ISS	10934466	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00057	Wnt signaling pathway	P01440	Cadherin	MONDO|Ensembl=ENSMODG00000000040|UniProtKB=F6S0B5	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF9	PROTOCADHERIN-18
P00029	Huntington disease	P00763	Hip-12	BOVIN|Ensembl=ENSBTAG00000005787|UniProtKB=Q5EA95	Intraflagellar transport protein 57 homolog	ISS			PTHR16011:SF0	INTRAFLAGELLAR TRANSPORT PROTEIN 57 HOMOLOG
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000017330|UniProtKB=Q5DRE0	Protocadherin beta-1	ISS	8120095	PubMed	PTHR24028:SF12	PROTOCADHERIN BETA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00059	p53 pathway	P01484	Chk2	DANRE|ZFIN=ZDB-GENE-030131-8942|UniProtKB=B0V1J5	Uncharacterized protein	IGI	12356735	PubMed	PTHR44167:SF1	SERINE/THREONINE-PROTEIN KINASE CHK2
P00056	VEGF signaling pathway	P01425	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02755	Methylmalonyl pathway	P03032	Methylmalonyl-CoA epimerase	RAT|RGD=1309966|UniProtKB=D4A197	Methylmalonyl CoA epimerase (Predicted), isoform CRA_d	ISS			PTHR43048:SF3	METHYLMALONYL-COA EPIMERASE, MITOCHONDRIAL
P00005	Angiogenesis	P00203	Erk	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02722	Acetate utilization	P02801	Acetate kinase	BACTN|EnsemblGenome=BT_3693|UniProtKB=Q8A1G8	Acetate kinase	ISS			PTHR21060:SF11	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00005	Angiogenesis	P00234	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8617307	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	CANLF|Ensembl=ENSCAFG00000008293|UniProtKB=E2R9M9	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF22	FRIZZLED-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	DICPU|Gene=DICPUDRAFT_45258|UniProtKB=F0Z9S5	Clathrin heavy chain	ISS	9388255	PubMed	PTHR10292:SF1	CLATHRIN HEAVY CHAIN
P04393	Ras Pathway	P04553	PAK	PANTR|Ensembl=ENSPTRG00000022187|UniProtKB=Q7YQL4	Serine/threonine-protein kinase PAK 3	ISS	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00057	Wnt signaling pathway	P01463	Kremen	HUMAN|HGNC=17550|UniProtKB=Q96MU8	Kremen protein 1	ISS			PTHR24269:SF13	KREMEN PROTEIN 1
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04398	p53 pathway feedback loops 2	P04651	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P02738	De novo purine biosynthesis	P02902	ADP reductase	ORNAN|Ensembl=ENSOANG00000010680|UniProtKB=F6U4A0	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=2652894|UniProtKB=Q80Y86	Mitogen-activated protein kinase 15	ISS	12787066	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00021	FGF signaling pathway	P00644	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	ISS	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00029	Huntington disease	P00805	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00552	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00059	p53 pathway	P01486	Akt	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	TAS	12655147	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	RAT|RGD=620027|UniProtKB=P08911	Muscarinic acetylcholine receptor M5	TAS	12181435	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00020	FAS signaling pathway	P00600	PARP	ARATH|TAIR=AT5G22470|UniProtKB=Q9FK91	Poly [ADP-ribose] polymerase 3	ISS			PTHR10459:SF54	POLY  ADP-RIBOSE  POLYMERASE 3
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8714|UniProtKB=Q9Y5F8	Protocadherin gamma-B7	IDA	8120095	PubMed	PTHR24028:SF113	PROTOCADHERIN GAMMA-B7
P00019	Endothelin signaling pathway	P00589	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00398	IP3R	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	IGI	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02920	dCTP deaminase	BRADU|Gene=BAC52761|UniProtKB=Q89DE3	tRNA-specific adenosine deaminase	ISS			PTHR11079:SF149	TRNA-SPECIFIC ADENOSINE DEAMINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00799	JNK-2	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	RAT|RGD=2870|UniProtKB=P01346	Insulin-like growth factor II	ISS	4504609	gi	PTHR11454:SF10	INSULIN-LIKE GROWTH FACTOR II
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00049	Parkinson disease	P01212	p38 MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00048	PI3 kinase pathway	P01192	p110	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02777	Succinate to proprionate conversion	P03161	Methylmalonyl-CoA mutase	HALSA|EnsemblGenome=VNG_0481G|UniProtKB=Q9HRZ1	Methylmalonyl-CoA mutase, subunit alpha	ISS			PTHR43589:SF2	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IGI	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IDA	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	RAT|RGD=1308834|UniProtKB=D4ADV8	Protein Dvl3	ISS	10409711	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00029	Huntington disease	P00777	CBP	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	TAS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00029	Huntington disease	P00807	Actin	BOVIN|Ensembl=ENSBTAG00000005714|UniProtKB=Q3ZC07	Actin, alpha cardiac muscle 1	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00059	p53 pathway	P01486	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00012	Cadherin signaling pathway	P00470	F-actin	ORYSJ|EnsemblGenome=OS03G0836000|UniProtKB=Q10AZ4	Actin-3	IC	11889126	PubMed	PTHR11937:SF254	ACTIN-1-RELATED
P00047	PDGF signaling pathway	P01143	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	SCLS1|Gene=SS1G_08733|UniProtKB=A7ETS6	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02738	De novo purine biosynthesis	P02891	GDP kinase	MYCTU|EnsemblGenome=Rv2445c|UniProtKB=P9WJH7	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05913	Enkephalin release	P05974	G-Protein (i)	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00045	Notch signaling pathway	P01104	Serrate	PANTR|Ensembl=ENSPTRG00000013250|UniProtKB=H2QJZ0	Delta-like protein	ISS	1286675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00010	B cell activation	P00402	Jnk	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	RAT|RGD=2738|UniProtKB=Q00960	Glutamate receptor ionotropic, NMDA 2B	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P05915	Opioid proenkephalin pathway	P05994	G-protein	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00059	p53 pathway	P04616	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	11256888	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MACMU|Ensembl=ENSMMUG00000020947|UniProtKB=F7CY46	Uncharacterized protein	ISS			PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P04393	Ras Pathway	P04566	Stat 1/3	HUMAN|HGNC=11364|UniProtKB=P40763	Signal transducer and activator of transcription 3	IDA	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00053	T cell activation	P01295	vav	HUMAN|HGNC=12657|UniProtKB=P15498	Proto-oncogene vav	IDA	14623913	PubMed	PTHR22826:SF112	PROTO-ONCOGENE VAV
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00029	Huntington disease	P00811	Arp2/3 complex	ANOGA|EnsemblGenome=AGAP008908|UniProtKB=Q7PWN2	AGAP008908-PA	TAS	12932731	PubMed	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P05918	p38 MAPK pathway	P06015	p38gamma	DANRE|ZFIN=ZDB-GENE-990415-257|UniProtKB=O42376	Mitogen-activated protein kinase 12	ISS	11707292	PubMed	PTHR24055:SF339	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=88397|UniProtKB=Q9ERZ4	Muscarinic acetylcholine receptor M2	IDA	91373358	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00034	Integrin signalling pathway	P00941	Integrin alpha	HUMAN|HGNC=6142|UniProtKB=P23229	Integrin alpha-6	IPI	3487386	PubMed	PTHR23220:SF9	INTEGRIN ALPHA-6
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	PHYPA|Gene=PHYPADRAFT_181075|UniProtKB=A9S453	Predicted protein	ISS			PTHR10410:SF5	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 14
P00013	Cell cycle	P00483	Cyclin E	STRPU|EnsemblGenome=SPU_001712|UniProtKB=W4XEA0	Uncharacterized protein	ISS	98112190	PubMed	PTHR10177:SF344	G1/S-SPECIFIC CYCLIN-E
P00010	B cell activation	P00371	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00586	Gq	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01143	ERK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	ISS	13430383	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	DROME|FlyBase=FBgn0263111|UniProtKB=P91645	Voltage-dependent calcium channel type A subunit alpha-1	ISS	8386525	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P05734	Synaptic vesicle trafficking	P05775	Synapsin	HUMAN|HGNC=11494|UniProtKB=P17600	Synapsin-1	TAS	15265868	PubMed	PTHR10841:SF22	SYNAPSIN-1
P00036	Interleukin signaling pathway	P00996	STAT	HUMAN|HGNC=11368|UniProtKB=P42226	Signal transducer and activator of transcription 6	IGI	94367369	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00017	DNA replication	P00527	Histones	CAEEL|WormBase=WBGene00001945|UniProtKB=Q10453	Histone H3.3 type 1	ISS	12413958	PubMed	PTHR11426:SF179	HISTONE H3.3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00056	VEGF signaling pathway	P01423	p38MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00020	FAS signaling pathway	P00615	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	12846562	PubMed	PTHR10202:SF13	PRESENILIN-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=62087|UniProtKB=P27704	Mitogen-activated protein kinase 6	ISS	8444355	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00006	Apoptosis signaling pathway	P00324	NIK	MACMU|Ensembl=ENSMMUG00000007863|UniProtKB=F7B742	Mitogen-activated protein kinase kinase kinase 14	ISS	9020361	PubMed	PTHR24361:SF226	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 14
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	YEAST|SGD=S000000201|UniProtKB=P24583	Protein kinase C-like 1	TAS	125549	gi	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	RCA	176910	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00053	T cell activation	P01312	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IDA	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00018	EGF receptor signaling pathway	P00558	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02740	De novo pyrimidine ribonucleotides biosythesis	P02926	Aspartate carbamoyltransferase	METJA|EnsemblGenome=MJ_1581|UniProtKB=Q58976	Aspartate carbamoyltransferase	ISS			PTHR11405:SF16	ASPARTATE CARBAMOYLTRANSFERASE, CHLOROPLASTIC
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00938	Cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P05734	Synaptic vesicle trafficking	P05779	Synaptobrevin	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02757	O-antigen biosynthesis	P03045	dTDP-glucose 4,6-dehydratase	DEIRA|EnsemblGenome=DR_0711|UniProtKB=Q9RWF7	NAD-dependent dehydratase	ISS			PTHR43000:SF2	SUBFAMILY NOT NAMED
P00009	Axon guidance mediated by netrin	P00363	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00566	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00936	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00049	Parkinson disease	P01230	Src kinase	XENTR|Xenbase=XB-GENE-5771921|UniProtKB=F6UTP2	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	DANRE|ZFIN=ZDB-GENE-050417-59|UniProtKB=Q15KE4	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00053	T cell activation	P01330	IKK	MACMU|Ensembl=ENSMMUG00000008351|UniProtKB=F7HRV5	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	CHICK|Ensembl=ENSGALG00000016406|UniProtKB=F1NLJ3	Uncharacterized protein	ISS	10558991	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00053	T cell activation	P01319	PAK	MOUSE|MGI=MGI=1339975|UniProtKB=O88643	Serine/threonine-protein kinase PAK 1	IDA	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	HUMAN|HGNC=1394|UniProtKB=O43497	Voltage-dependent T-type calcium channel subunit alpha-1G	IDA	18021322	PubMed	PTHR10037:SF137	VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1G
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01407	Erk	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P02738	De novo purine biosynthesis	P02894	IMP cyclohydrolase	ARATH|TAIR=AT2G35040|UniProtKB=Q8RWT5	AICARFT/IMPCHase bienzyme family protein	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=17175|UniProtKB=Q9P212	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	10934033	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P04374	5HT2 type receptor mediated signaling pathway	P04417	5HT transporter	RAT|RGD=3714|UniProtKB=P31652	Sodium-dependent serotonin transporter	ISS	14653308	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00010	B cell activation	P00368	vav	CHICK|Ensembl=ENSGALG00000001915|UniProtKB=R4GI39	Uncharacterized protein	IGI	14623913	PubMed	PTHR22826:SF97	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01438	PP2A	CANLF|Ensembl=ENSCAFG00000006453|UniProtKB=F6X958	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00046	Oxidative stress response	P01135	p38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00059	p53 pathway	G01579	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00017	DNA replication	P00527	Histones	MACMU|Ensembl=ENSMMUG00000032409|UniProtKB=F6UJL2	Histone H3	ISS	91033046	PubMed	PTHR11426:SF179	HISTONE H3.3
P00021	FGF signaling pathway	P00643	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000002349|UniProtKB=P61267	Syntaxin-1B	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01408	Akt/PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	IDA	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MONDO|Ensembl=ENSMODG00000009514|UniProtKB=F7EVK3	Uncharacterized protein	ISS	10664585	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00018	EGF receptor signaling pathway	P00539	14-3-3	MOUSE|MGI=MGI=1891917|UniProtKB=Q9CQV8	14-3-3 protein beta/alpha	ISS	91108808	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00056	VEGF signaling pathway	P01417	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P02765	Phenylalanine biosynthesis	P03099	Prephenate dehydratase	ARATH|TAIR=AT1G08250|UniProtKB=Q9SGD6	Arogenate dehydratase/prephenate dehydratase 6, chloroplastic	ISS			PTHR21022:SF14	AROGENATE DEHYDRATASE 3, CHLOROPLASTIC-RELATED
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000001583|UniProtKB=F7BBM1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00019	Endothelin signaling pathway	P00590	IP3 R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IGI	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	RCA	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P05913	Enkephalin release	P05972	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	ANOGA|EnsemblGenome=AGAP001473|UniProtKB=Q7PXM0	AGAP001473-PA	ISS			PTHR43347:SF3	ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	ANOGA|EnsemblGenome=AGAP001306|UniProtKB=Q7PUB7	Actin-related protein 2/3 complex subunit 4	ISS	5031595	gi	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00021	FGF signaling pathway	P00629	PP2A	MOUSE|MGI=MGI=2388480|UniProtKB=Q6PD28	Protein Ppp2r5b	ISS	11531413	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00057	Wnt signaling pathway	P01457	GBeta	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IDA	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00012	Cadherin signaling pathway	P00470	F-actin	DICDI|dictyBase=DDB_G0289487|UniProtKB=P07829	Actin-3	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05916	Opioid prodynorphin pathway	P06001	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00018	EGF receptor signaling pathway	P00557	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	RAT|RGD=621705|UniProtKB=Q8VHN2	Glutamate receptor ionotropic, NMDA 3B	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P00021	FGF signaling pathway	P00628	JNK1-3	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00036	Interleukin signaling pathway	P00981	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	TAS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	TAKRU|Ensembl=ENSTRUG00000003589|UniProtKB=H2S7P7	Uncharacterized protein	ISS	15328036	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P05916	Opioid prodynorphin pathway	P06001	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	ISS	96149441	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00048	PI3 kinase pathway	P01177	P110ACT	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00477	GSK3beta	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Ensembl=ENSBTAG00000006582|UniProtKB=E1BFV6	Uncharacterized protein	ISS	12562507	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P04397	p53 pathway by glucose deprivation	P04641	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00817	TOR	DROME|FlyBase=FBgn0021796|UniProtKB=Q9VK45	Target of rapamycin	TAS	14526383	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	ANOGA|EnsemblGenome=AGAP003021|UniProtKB=Q7PQY9	Clathrin heavy chain	IDA	9388255	PubMed	PTHR10292:SF1	CLATHRIN HEAVY CHAIN
P00049	Parkinson disease	P01236	Casein kinase II	YARLI|EnsemblGenome=YALI0_D16863g|UniProtKB=Q6C8U8	YALI0D16863p	IDA	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00149	Pen-2	BOVIN|Ensembl=ENSBTAG00000018593|UniProtKB=Q5G235	Gamma-secretase subunit PEN-2	IDA	12110170	PubMed	PTHR16318:SF0	GAMMA-SECRETASE SUBUNIT PEN-2
P00025	Hedgehog signaling pathway	P00690	Cubitus interruptus	BOVIN|Ensembl=ENSBTAG00000006631|UniProtKB=A6H727	GLI1 protein	ISS			PTHR19818:SF2	ZINC FINGER PROTEIN GLI1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01167	Ets	MONDO|Ensembl=ENSMODG00000021010|UniProtKB=F6QZT8	Uncharacterized protein (Fragment)	ISS	15298723	PubMed	PTHR11849:SF195	GA-BINDING PROTEIN ALPHA CHAIN
P00047	PDGF signaling pathway	P01173	STAT	CHICK|Ensembl=ENSGALG00000003267|UniProtKB=Q6DV79	Signal transducer and activator of transcription 3	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00010	B cell activation	P00391	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00058	mRNA splicing	P01476	U4	HUMAN|HGNC=17348|UniProtKB=O43395	U4/U6 small nuclear ribonucleoprotein Prp3	IGI	9328476	PubMed	PTHR14212:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	RCA	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04393	Ras Pathway	P04559	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12874273	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04657	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MACMU|Ensembl=ENSMMUG00000004253|UniProtKB=F6YQ28	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF165	COLLAGENASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	BOVIN|Gene=CCL3|UniProtKB=Q8SQA6	C-C motif chemokine 3	ISS			PTHR12015:SF91	C-C MOTIF CHEMOKINE 3-RELATED
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01332	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	1718748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	SCLS1|EnsemblGenome=SS1G_12241|UniProtKB=A7F2U3	Casein kinase II	ISS	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000009626|UniProtKB=F6ZYQ0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00190	RasGAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	ISS	2574500	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00005	Angiogenesis	P00194	Paxillin	CHICK|Gene=PXN|UniProtKB=P49024	Paxillin	ISS	7579684	PubMed	PTHR24216:SF11	PAXILLIN
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00029	Huntington disease	P00776	c-Jun	CHICK|Gene=JUN|UniProtKB=P18870	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	TAS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=1306541|UniProtKB=D3ZVF3	Phosphoinositide-3-kinase, class 2, beta polypeptide (Predicted)	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	IC	3755548	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00047	PDGF signaling pathway	P01161	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00009	Axon guidance mediated by netrin	P00366	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P05912	Dopamine receptor mediated signaling pathway	P05944	COMT	PANTR|Ensembl=ENSPTRG00000014070|UniProtKB=H2QL91	Catechol-O-methyltransferase	ISS	12842307	PubMed	PTHR43836:SF3	CATECHOL O-METHYLTRANSFERASE
P00005	Angiogenesis	P00223	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00024	Glycolysis	P00679	Aldolase	CHICK|Ensembl=ENSGALG00000015544|UniProtKB=P07341	Fructose-bisphosphate aldolase B	ISS	85182565	PubMed	PTHR11627:SF2	FRUCTOSE-BISPHOSPHATE ALDOLASE B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00012	Cadherin signaling pathway	P00475	Frizzled	RAT|RGD=628817|UniProtKB=Q8K4C8	Frizzled homolog 9 (Drosophila)	ISS	11212302	PubMed	PTHR11309:SF79	FRIZZLED-9
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IC	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	IDA	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00045	Notch signaling pathway	P01106	Mastermind	PANTR|Ensembl=ENSPTRG00000033932|UniProtKB=H2RBB8	Uncharacterized protein	ISS	12644465	PubMed	PTHR15692:SF19	MASTERMIND-LIKE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=4596|UniProtKB=Q14833	Metabotropic glutamate receptor 4	IDA	12351712	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	TAS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00145	CD44	CHICK|Ensembl=ENSGALG00000007849|UniProtKB=F1NL98	Uncharacterized protein	IDA	12223485	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DANRE|ZFIN=ZDB-GENE-040625-35|UniProtKB=Q6IQL9	Novel actin protein	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00018	EGF receptor signaling pathway	P00565	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	3755548	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	XENTR|Xenbase=XB-GENE-1014077|UniProtKB=F6TKJ2	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00015	Circadian clock system	G01497	cry	RAT|RGD=620935|UniProtKB=Q923I8	Cryptochrome-2	IDA	14507900	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00047	PDGF signaling pathway	P01153	GSK3	YEAST|SGD=S000004747|UniProtKB=P38615	Serine/threonine-protein kinase RIM11/MSD1	ISS	12615961	PubMed	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00030	Hypoxia response via HIF activation	P00814	P300	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	IDA	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04398	p53 pathway feedback loops 2	P04651	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IDA	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00059	p53 pathway	P04633	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	CANLF|Gene=HTR1D|UniProtKB=P11614	5-hydroxytryptamine receptor 1D	ISS	14645495	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	TAS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04570	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1718748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00029	Huntington disease	P00807	Actin	MACMU|Ensembl=ENSMMUG00000007027|UniProtKB=F7F210	Alpha-cardiac actin	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00029	Huntington disease	P00796	Kainate receptor	MONDO|Ensembl=ENSMODG00000020977|UniProtKB=F6S5B1	Uncharacterized protein (Fragment)	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00060	Ubiquitin proteasome pathway	P01492	E1	MONDO|Ensembl=ENSMODG00000006136|UniProtKB=F7BSZ9	Uncharacterized protein	ISS			PTHR10953:SF3	UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7
P04393	Ras Pathway	P04558	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DANRE|ZFIN=ZDB-GENE-040426-1489|UniProtKB=Q6PHV0	Syntaxin 3A	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	HUMAN|HGNC=286|UniProtKB=P07550	Beta-2 adrenergic receptor	IDA	7669252	PubMed	PTHR24248:SF21	BETA-2 ADRENERGIC RECEPTOR
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_56687|UniProtKB=C3YC50	Putative uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00623	FGF	MOUSE|MGI=MGI=1931627|UniProtKB=Q9ESL8	Fibroblast growth factor 16	IGI	12619867	PubMed	PTHR11486:SF27	FIBROBLAST GROWTH FACTOR 16
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04393	Ras Pathway	P04570	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PLAF7|EnsemblGenome=PF14_0124|UniProtKB=Q8ILW9	Actin-2	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00006	Apoptosis signaling pathway	P00269	MAPK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01294	NFAT	BOVIN|Ensembl=ENSBTAG00000004368|UniProtKB=F1MSU2	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	SCHPO|PomBase=SPAC1687.15|UniProtKB=Q10452	Protein kinase gsk3	IDA	12615961	PubMed	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00046	Oxidative stress response	P01136	Elk-1	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	14670631	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	XENTR|Xenbase=XB-GENE-969601|UniProtKB=Q28H40	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00029	Huntington disease	P00801	Fos protein	XENTR|Xenbase=XB-GENE-866811|UniProtKB=F7EI91	Uncharacterized protein (Fragment)	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	P00547	PP2A	PANTR|Ensembl=ENSPTRG00000003853|UniProtKB=H2Q411	Protein phosphatase 2, regulatory subunit B', beta	ISS	10092233	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00056	VEGF signaling pathway	P01417	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	BOVIN|Gene=PCSK2|UniProtKB=Q9GLR0	Neuroendocrine convertase 2	IDA			PTHR42884:SF13	NEUROENDOCRINE CONVERTASE 2
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00004	Alzheimer disease-presenilin pathway	P00170	Aph-1	ANOGA|EnsemblGenome=AGAP009816|UniProtKB=Q7PM79	AGAP009816-PA	IDA	12110170	PubMed	PTHR12889:SF0	GAMMA-SECRETASE SUBUNIT APH-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	RCA			PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00006	Apoptosis signaling pathway	P00260	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CIOIN|Ensembl=ENSCING00000000848|UniProtKB=F6SCP4	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00564	Rac	XENTR|Xenbase=XB-GENE-493450|UniProtKB=B5DEW2	Uncharacterized protein	ISS			PTHR24072:SF150	RAS HOMOLOG GENE FAMILY, MEMBER GA-RELATED
P00019	Endothelin signaling pathway	P00586	Gq	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01188	Gbetagamma	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	IC	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	RAT|RGD=2746|UniProtKB=P31424	Metabotropic glutamate receptor 5	ISS	12351712	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	94179345	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00057	Wnt signaling pathway	P01428	Frizzled	PANTR|Ensembl=ENSPTRG00000012855|UniProtKB=H2QJA9	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF126	FRIZZLED-5
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=19663|UniProtKB=Q9UBI6	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	IDA	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00021	FGF signaling pathway	P00648	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00055	Transcription regulation by bZIP transcription factor	P01395	TFIIE	SCHPO|PomBase=SPAC458.07|UniProtKB=Q9P3W1	Transcription initiation factor IIE subunit alpha	ISS			PTHR13097:SF7	NOVEL PROTEIN SIMILAR TO VERTEBRATE GENERAL TRANSCRIPTION FACTOR IIE POLYPEPTIDE 1 ALPHA 56KDA  GTF2E1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00005	Angiogenesis	P00204	PLD	MACMU|Ensembl=ENSMMUG00000023289|UniProtKB=F7FFD2	Uncharacterized protein	ISS	10497874	PubMed	PTHR18896:SF57	PHOSPHOLIPASE D1
P00006	Apoptosis signaling pathway	P00310	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IGI	12464394	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P06664	Gonadotropin-releasing hormone receptor pathway	P06786	ERK1/2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	RCA	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	TAS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MOUSE|MGI=MGI=1925616|UniProtKB=Q9JMF3	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13	IC	10391901	PubMed	PTHR15936:SF2	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-13
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	RAT|RGD=619965|UniProtKB=P26769	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	176948	OMIM	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00948	Rho	XENTR|Xenbase=XB-GENE-489222|UniProtKB=Q28GJ8	Ras homolog gene family, member A	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00590	IP3 R	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	IGI	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00007	Axon guidance mediated by semaphorins	P00340	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	20010089	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CAEEL|WormBase=WBGene00006539|UniProtKB=G5EF01	TuBulin, Beta	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00034	Integrin signalling pathway	P00920	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00049	Parkinson disease	P01211	ERK	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	IDA	12001934	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CHICK|GeneID=396254|UniProtKB=P09244	Tubulin beta-7 chain	ISS	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	21150461	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05730	Endogenous cannabinoid signaling	P05746	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P06664	Gonadotropin-releasing hormone receptor pathway	P06798	PKCe/theta	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04559	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00034	Integrin signalling pathway	P00926	GRAF	MACMU|Ensembl=ENSMMUG00000014953|UniProtKB=F6VTW2	Uncharacterized protein	ISS	8649427	PubMed	PTHR12552:SF5	RHO GTPASE-ACTIVATING PROTEIN 10
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12676940	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00036	Interleukin signaling pathway	P00990	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01457	GBeta	DROME|FlyBase=FBgn0001105|UniProtKB=P26308	Guanine nucleotide-binding protein subunit beta-1	IDA	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00471	Cadherin	CHICK|Ensembl=ENSGALG00000016908|UniProtKB=E1BQF1	Uncharacterized protein	ISS	8120095	PubMed	PTHR43912:SF5	PROTOCADHERIN-9
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05931	EGR	HUMAN|HGNC=3238|UniProtKB=P18146	Early growth response protein 1	RCA			PTHR44685:SF1	EARLY GROWTH RESPONSE PROTEIN 1
P04397	p53 pathway by glucose deprivation	P04639	AMPK	CANLF|Ensembl=ENSCAFG00000018614|UniProtKB=F1PIY1	Uncharacterized protein	ISS			PTHR24343:SF306	5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1
P00009	Axon guidance mediated by netrin	P00357	Netrin	XENTR|Xenbase=XB-GENE-989335|UniProtKB=F7CBX5	Uncharacterized protein (Fragment)	ISS	9427245	PubMed	PTHR10574:SF365	NETRIN-1
P00018	EGF receptor signaling pathway	P00557	PI3K	DROME|FlyBase=FBgn0015278|UniProtKB=Q7K3H0	LD28067p	IGI	96278830	PubMed	PTHR10048:SF64	LD28067P
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00057	Wnt signaling pathway	P01444	Wnt	BRAFL|Gene=BRAFLDRAFT_104698|UniProtKB=C3XYW6	Protein Wnt (Fragment)	IDA	8717036	PubMed	PTHR12027:SF81	SUBFAMILY NOT NAMED
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01471	alpha-catenin	CHICK|Ensembl=ENSGALG00000002447|UniProtKB=E1C7M7	Uncharacterized protein	ISS	1768802	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00049	Parkinson disease	P01219	SAPK	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	MACMU|Ensembl=ENSMMUG00000014555|UniProtKB=F7GT55	Syntaxin-1A isoform 1	ISS	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00019	Endothelin signaling pathway	P00590	IP3 R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04393	Ras Pathway	P04543	MEKK1/4	RAT|RGD=1311192|UniProtKB=A0A0G2K3R1	Protein Map3k4	ISS	10207617	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P04395	Vasopressin synthesis	P04593	Glycopeptide	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	IC	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00006	Apoptosis signaling pathway	P00326	FAS ligand	MOUSE|MGI=MGI=99255|UniProtKB=P41047	Tumor necrosis factor ligand superfamily member 6	ISS	12787569	PubMed	PTHR11471:SF33	TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 6
P00012	Cadherin signaling pathway	P00470	F-actin	DICPU|Gene=DICPUDRAFT_46519|UniProtKB=F0Z796	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00023	General transcription regulation	P00668	TFIIB	MOUSE|MGI=MGI=107428|UniProtKB=Q8BTU1	Cilia- and flagella-associated protein 20	ISS			PTHR12458:SF8	CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IGI	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IDA	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00059	p53 pathway	G04694	p110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00034	Integrin signalling pathway	P00941	Integrin alpha	MACMU|Ensembl=ENSMMUG00000011661|UniProtKB=F7HGW0	Uncharacterized protein	ISS	10778855	PubMed	PTHR23220:SF5	INTEGRIN ALPHA-8
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01461	FrzB	HUMAN|HGNC=3959|UniProtKB=Q92765	Secreted frizzled-related protein 3	ISS	9118218	PubMed	PTHR11309:SF97	SECRETED FRIZZLED-RELATED PROTEIN 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	RAT|RGD=2350|UniProtKB=P12390	Neuronal acetylcholine receptor subunit beta-2	IC	22213672	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IDA	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	MACMU|Ensembl=ENSMMUG00000009928|UniProtKB=F6Y5E5	Uncharacterized protein	ISS			PTHR11767:SF17	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 3
P00057	Wnt signaling pathway	P01440	Cadherin	CANLF|Ensembl=ENSCAFG00000010175|UniProtKB=E2RJN9	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF311	CADHERIN-22
P00034	Integrin signalling pathway	P00947	Laminin	MACMU|Ensembl=ENSMMUG00000022136|UniProtKB=F7H3A8	Uncharacterized protein	ISS	2538453	PubMed	PTHR10574:SF291	LAMININ SUBUNIT ALPHA-2
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04570	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	IDA	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04393	Ras Pathway	P04546	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00047	PDGF signaling pathway	P01142	p90RSK	HUMAN|HGNC=10437|UniProtKB=Q9UBS0	Ribosomal protein S6 kinase beta-2	ISS	15116068	PubMed	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00021	FGF signaling pathway	P00646	RasGAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	2842690	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00059	p53 pathway	P04615	MTA2	MOUSE|MGI=MGI=1346340|UniProtKB=Q9R190	Metastasis-associated protein MTA2	ISS	11099047	PubMed	PTHR10865:SF4	METASTASIS-ASSOCIATED PROTEIN MTA2
P00029	Huntington disease	G01531	BDNF	BOVIN|Ensembl=ENSBTAG00000008134|UniProtKB=Q95106	Brain-derived neurotrophic factor	ISS	12117585	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00036	Interleukin signaling pathway	P00996	STAT	MONDO|Ensembl=ENSMODG00000014816|UniProtKB=F7CHH2	Signal transducer and activator of transcription	ISS	96210005	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000000576|UniProtKB=F6ZW11	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF91	CADHERIN-7
P04393	Ras Pathway	P04579	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	7798194	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	BOVIN|Ensembl=ENSBTAG00000005903|UniProtKB=F1N1K8	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2521|UniProtKB=P19020	D(3) dopamine receptor	IDA	2137198	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	11832947	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008026|UniProtKB=H2QAZ2	Syntaxin 1B	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00005	Angiogenesis	P00238	Ras	CHICK|Ensembl=ENSGALG00000014033|UniProtKB=E1BTS2	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IGI	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000014334|UniProtKB=F7CYY6	Uncharacterized protein	ISS	2039532	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_56698|UniProtKB=C3XYC3	Putative uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	7667318	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	P00543	ERK1-2	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	97442349	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	RAT|RGD=1309504|UniProtKB=D3ZRN3	Protein Actbl2	ISS	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P02725	Allantoin degradation	P02823	Tartronate semi-aldehyde dehydrogenase	ECOLI|EcoGene=EG11176|UniProtKB=P0ABQ2	2-hydroxy-3-oxopropionate reductase	ISS			PTHR43060:SF3	2-HYDROXY-3-OXOPROPIONATE REDUCTASE
P06664	Gonadotropin-releasing hormone receptor pathway	G06879	PACAP	MOUSE|MGI=MGI=105094|UniProtKB=O70176	Pituitary adenylate cyclase-activating polypeptide	RCA			PTHR11213:SF1	PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE
P04395	Vasopressin synthesis	P04594	Neurophysin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	DROME|FlyBase=FBgn0010417|UniProtKB=P49847	Transcription initiation factor TFIID subunit 6	ISS			PTHR10221:SF12	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6
P00012	Cadherin signaling pathway	P00464	Fyn	DANRE|ZFIN=ZDB-GENE-030903-5|UniProtKB=Q6EWH2	Tyrosine-protein kinase fyna	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P02746	Heme biosynthesis	P02975	Uroporphyrinogen decarboxylase	ECOLI|EcoGene=EG11543|UniProtKB=P29680	Uroporphyrinogen decarboxylase	ISS			PTHR21091:SF2	UROPORPHYRINOGEN DECARBOXYLASE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MOUSE|MGI=MGI=87948|UniProtKB=P46664	Adenylosuccinate synthetase isozyme 2	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	MOUSE|MGI=MGI=1321161|UniProtKB=P62715	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00971	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	15210125	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IDA	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05938	RhoA	DANRE|ZFIN=ZDB-GENE-040718-144|UniProtKB=Q6DHE8	Rho-related GTP-binding protein RhoA-D	ISS	10556059	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ORNAN|Ensembl=ENSOANG00000007581|UniProtKB=F6QWB7	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00046	Oxidative stress response	P01135	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	RCA	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	HUMAN|HGNC=4597|UniProtKB=P41594	Metabotropic glutamate receptor 5	ISS	12488551	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00029	Huntington disease	P00805	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00887	IRS 1-4	PANTR|Ensembl=ENSPTRG00000012989|UniProtKB=H2QJJ4	Insulin receptor substrate 1	ISS	12701063	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	SCHPO|PomBase=SPAC22F8.11|UniProtKB=P40977	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00057	Wnt signaling pathway	P01435	SWI/SNF	CAEEL|WormBase=WBGene00044072|UniProtKB=Q09646	Uncharacterized protein	ISS	11532957	PubMed	PTHR13844:SF7	BRAHMA-ASSOCIATED PROTEIN OF 60 KDA
P00023	General transcription regulation	P00658	TBP-associated factors	ARATH|TAIR=AT5G15570|UniProtKB=Q9LF25	Bromodomain transcription factor	ISS	604905	OMIM	PTHR12321:SF53	BROMODOMAIN TRANSCRIPTION FACTOR
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CANLF|Ensembl=ENSCAFG00000015662|UniProtKB=E2RHY4	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00025	Hedgehog signaling pathway	P00682	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00006	Apoptosis signaling pathway	P00269	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00188	Ets	MACMU|Ensembl=ENSMMUG00000020706|UniProtKB=F6PU72	Uncharacterized protein	ISS	3060801	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00047	PDGF signaling pathway	P01142	p90RSK	MACMU|Ensembl=ENSMMUG00000019305|UniProtKB=F6S3T8	Ribosomal protein S6 kinase	ISS	11861821	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MACMU|Ensembl=ENSMMUG00000004886|UniProtKB=F7AGT9	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04371	5-Hydroxytryptamine biosynthesis	P04399	Tryptophan hydroxylase	MACMU|Gene=TPH2|UniProtKB=Q2HZ26	Tryptophan 5-hydroxylase 2	ISS	14597720	PubMed	PTHR11473:SF16	TRYPTOPHAN 5-HYDROXYLASE 2
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000019361|UniProtKB=H2QUV3	Uncharacterized protein	ISS	20012997	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00016	Cytoskeletal regulation by Rho GTPase	P00525	N-WASP	ORNAN|Ensembl=ENSOANG00000004830|UniProtKB=F7E2I0	Uncharacterized protein	ISS	12932731	PubMed	PTHR23202:SF39	NEURAL WISKOTT-ALDRICH SYNDROME PROTEIN
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P02788	Xanthine and guanine salvage pathway	P03249	Guanine deaminase	RAT|RGD=621617|UniProtKB=Q9WTT6	Guanine deaminase	ISS	11837778	gi	PTHR11271:SF6	GUANINE DEAMINASE
P00047	PDGF signaling pathway	P01150	PKC	YEAST|SGD=S000000201|UniProtKB=P24583	Protein kinase C-like 1	ISS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00046	Oxidative stress response	P01131	MKP5	HUMAN|HGNC=25034|UniProtKB=Q5VZP5	Inactive dual specificity phosphatase 27	ISS			PTHR10159:SF25	INACTIVE DUAL SPECIFICITY PHOSPHATASE 27
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	HUMAN|HGNC=4579|UniProtKB=P39086	Glutamate receptor ionotropic, kainate 1	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00996	STAT	MONDO|Ensembl=ENSMODG00000014816|UniProtKB=F7CHH2	Signal transducer and activator of transcription	ISS	22320921	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P05912	Dopamine receptor mediated signaling pathway	P05966	EPB41	BOVIN|Ensembl=ENSBTAG00000001640|UniProtKB=F1N611	Uncharacterized protein	ISS	12181426	PubMed	PTHR23280:SF24	BAND 4.1-LIKE PROTEIN 1
P00057	Wnt signaling pathway	P01443	Phospholipase C	DROME|FlyBase=FBgn0004611|UniProtKB=P25455	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II	IDA	1707501	PubMed	PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00059	p53 pathway	G01579	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	IGI	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	PANTR|Ensembl=ENSPTRG00000008770|UniProtKB=H2QC99	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF385	MYOSIN-2
P00049	Parkinson disease	P01235	Fyn kinase	RAT|RGD=2641|UniProtKB=Q62844	Tyrosine-protein kinase Fyn	IDA	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P02771	Pyrimidine Metabolism	P03124	Methylmalonate Semialdehyde Dehydrogenase	RAT|RGD=621556|UniProtKB=Q02253	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	NAS	1527093	PubMed	PTHR43866:SF3	METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE  ACYLATING , MITOCHONDRIAL
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	ANOGA|Gene=AgaP_AGAP010493|UniProtKB=Q7Q8X9	AGAP010493-PA (Fragment)	ISS			PTHR12228:SF0	TAF7 RNA POLYMERASE II, TATA BOX BINDING PROTEIN  TBP -ASSOCIATED FACTOR
P00057	Wnt signaling pathway	P01446	Calcineurin	XENTR|Xenbase=XB-GENE-952299|UniProtKB=B0BLZ8	Serine/threonine-protein phosphatase	ISS	12015605	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01143	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEEL|WormBase=WBGene00018620|UniProtKB=O44588	Uncharacterized protein	ISS	3755548	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P00047	PDGF signaling pathway	P01151	PKB	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04619	HMG1	MACMU|Ensembl=ENSMMUG00000001275|UniProtKB=F6VRM9	Uncharacterized protein	ISS			PTHR13711:SF164	HIGH MOBILITY GROUP PROTEIN B1-RELATED
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05730	Endogenous cannabinoid signaling	P05746	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=18539|UniProtKB=P61266	Syntaxin-1B	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	YARLI|EnsemblGenome=YALI0_D08272g|UniProtKB=Q9UVF3	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00025	Hedgehog signaling pathway	P00690	Cubitus interruptus	MACMU|Ensembl=ENSMMUG00000013614|UniProtKB=F7GN18	Uncharacterized protein	ISS	15994174	PubMed	PTHR19818:SF5	TRANSCRIPTIONAL ACTIVATOR GLI3
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	HUMAN|HGNC=2453|UniProtKB=P49674	Casein kinase I isoform epsilon	ISS	11865049	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00012	Cadherin signaling pathway	P00466	EGFR	MACMU|Ensembl=ENSMMUG00000020758|UniProtKB=F7HEH3	Uncharacterized protein	ISS	20477399	gi	PTHR24416:SF88	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	11832947	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04398	p53 pathway feedback loops 2	G04711	SIAH-1	HUMAN|HGNC=10857|UniProtKB=Q8IUQ4	E3 ubiquitin-protein ligase SIAH1	ISS	14985507	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00052	TGF-beta signaling pathway	P01275	P38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	TAS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	XENTR|Ensembl=ENSXETG00000021375|UniProtKB=F6T423	Uncharacterized protein	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00049	Parkinson disease	P01211	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00049	Parkinson disease	P01227	20S proteasome	ARATH|TAIR=AT1G79210|UniProtKB=Q8L4A7	Proteasome subunit alpha type-2-B	TAS	12859888	PubMed	PTHR11599:SF16	PROTEASOME SUBUNIT ALPHA TYPE-2
P00051	TCA cycle	P01274	Succinyl CoA Synthetase	RAT|RGD=619821|UniProtKB=P13086	Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial	ISS	97407896	PubMed	PTHR11117:SF2	SUCCINYL-COA LIGASE  ADP/GDP-FORMING  SUBUNIT ALPHA, MITOCHONDRIAL
P00047	PDGF signaling pathway	P01161	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00463	betacatenin	CHICK|Ensembl=ENSGALG00000011905|UniProtKB=F1NHT7	Uncharacterized protein	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONBE|Gene=37852|UniProtKB=A9V489	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CANLF|Ensembl=ENSCAFG00000001445|UniProtKB=E2RNH4	Uncharacterized protein	ISS			PTHR23291:SF16	PROTEIN LIFEGUARD 1
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P02775	Salvage pyrimidine ribonucleotides	P03149	Cytidine kinase	ARATH|TAIR=AT3G27440|UniProtKB=Q9LTY6	Uridine kinase-like protein 5	ISS			PTHR10285:SF75	URIDINE KINASE-LIKE PROTEIN 5
P02784	Tyrosine biosynthesis	P03212	Chorismate mutase	ARATH|TAIR=AT3G29200|UniProtKB=P42738	Chorismate mutase 1, chloroplastic	ISS			PTHR21145:SF0	CHORISMATE MUTASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=5287|UniProtKB=P28222	5-hydroxytryptamine receptor 1B	IDA	11701344	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P00003	Alzheimer disease-amyloid secretase pathway	P00084	X11alpha	RAT|RGD=620844|UniProtKB=O35430	Amyloid beta A4 precursor protein-binding family A member 1	IDA	9614075	PubMed	PTHR12345:SF14	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 1
P05918	p38 MAPK pathway	P06020	p38delta	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	RCA	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000004690|UniProtKB=Q5F3W3	Mitogen-activated protein kinase 6	ISS	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06959	CCKR signaling map	P07143	RPS6	HUMAN|HGNC=10429|UniProtKB=P62753	40S ribosomal protein S6	RCA	9299479	PubMed	PTHR11502:SF6	40S RIBOSOMAL PROTEIN S6
P00046	Oxidative stress response	P01126	ATF2	MONDO|Ensembl=ENSMODG00000009514|UniProtKB=F7EVK3	Uncharacterized protein	ISS	11390664	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00006	Apoptosis signaling pathway	P00260	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	10704417	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00048	PI3 kinase pathway	P01198	FOXO	PANTR|Ensembl=ENSPTRG00000018476|UniProtKB=H2R710	Forkhead box O3	ISS	12884295	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00007	Axon guidance mediated by semaphorins	P00340	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00048	PI3 kinase pathway	P01185	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00047	PDGF signaling pathway	P01143	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04393	Ras Pathway	P04557	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	IDA	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	HUMAN|HGNC=3026|UniProtKB=P21918	D(1B) dopamine receptor	ISS	15328036	PubMed	PTHR43893:SF8	D 1B  DOPAMINE RECEPTOR
P00048	PI3 kinase pathway	P01179	PKB	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	BOVIN|Ensembl=ENSBTAG00000017542|UniProtKB=A4IFL4	PPARD protein	ISS	12356903	PubMed	PTHR24082:SF15	PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DELTA
P00010	B cell activation	P00398	IP3R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	BOVIN|Ensembl=ENSBTAG00000001060|UniProtKB=P25930	C-X-C chemokine receptor type 4	ISS	4503175	gi	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	CAEEL|WormBase=WBGene00002173|UniProtKB=Q9Y0A1	Inositol 1,4,5-trisphosphate receptor itr-1	ISS	12880387	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	DROME|FlyBase=FBgn0033388|UniProtKB=A1Z7R6	CG8046, isoform A	ISS			PTHR23507:SF1	GH23453P-RELATED
P00057	Wnt signaling pathway	P01465	Ggamma	XENTR|Xenbase=XB-GENE-961282|UniProtKB=Q6DF43	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00050	Plasminogen activating cascade	P01250	MMP-13	MACMU|Ensembl=ENSMMUG00000004253|UniProtKB=F6YQ28	Uncharacterized protein	ISS	Fang,Y.,Kitchell,B.E.,Paria,B.andBalkin,R.	free text	PTHR10201:SF165	COLLAGENASE 3
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	HUMAN|HGNC=5974|UniProtKB=P78552	Interleukin-13 receptor subunit alpha-1	TAS	12223527	PubMed	PTHR23036:SF89	INTERLEUKIN-13 RECEPTOR SUBUNIT ALPHA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	TAS	9094314	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02747	Histidine biosynthesis	P02991	Histidinephosphate aminotransferase	THEMA|EnsemblGenome=TM_1040|UniProtKB=Q9X0D0	Histidinol-phosphate aminotransferase	ISS			PTHR43643:SF3	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00223	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00047	PDGF signaling pathway	P01173	STAT	MOUSE|MGI=MGI=103036|UniProtKB=P42230	Signal transducer and activator of transcription 5A	ISS	14662325	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95814|UniProtKB=Q60934	Glutamate receptor ionotropic, kainate 1	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00059	p53 pathway	G01579	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00021	FGF signaling pathway	P00648	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01300	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IDA	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	HUMAN|HGNC=6091|UniProtKB=P06213	Insulin receptor	ISS	6754360	gi	PTHR24416:SF402	INSULIN RECEPTOR
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00632	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IGI	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00029	Huntington disease	P00795	BDNF	DANRE|ZFIN=ZDB-GENE-000412-1|UniProtKB=Q6NZ01	Bdnf protein	TAS	12117585	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	ANOGA|EnsemblGenome=AGAP011481|UniProtKB=Q7PMY1	AGAP011481-PA (Fragment)	IDA			PTHR24247:SF117	5-HYDROXYTRYPTAMINE RECEPTOR 2A-RELATED
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	DROME|FlyBase=FBgn0030576|UniProtKB=Q9VY22	FI18259p1	ISS			PTHR23507:SF28	FI18259P1-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	BOVIN|Ensembl=ENSBTAG00000013047|UniProtKB=E1BLE8	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04393	Ras Pathway	P04570	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00223	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P06587	Nicotine pharmacodynamics pathway	P06590	GNG	MOUSE|MGI=MGI=102705|UniProtKB=P63213	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	13430383	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00019	Endothelin signaling pathway	P00591	PLCbeta	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00010	B cell activation	P00398	IP3R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00034	Integrin signalling pathway	P00920	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Ensembl=ENSPTRG00000022245|UniProtKB=H2QZ29	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	94280860	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00059	p53 pathway	P04630	PP2A	BOVIN|Ensembl=ENSBTAG00000000469|UniProtKB=P67774	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01417	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01160	IP3 receptor	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00019	Endothelin signaling pathway	P00567	PKG	MACMU|Ensembl=ENSMMUG00000019859|UniProtKB=F7GTI6	cGMP-dependent protein kinase	ISS	12775716	PubMed	PTHR24353:SF24	SUBFAMILY NOT NAMED
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	DROME|FlyBase=FBgn0028692|UniProtKB=Q9V3P6	26S proteasome non-ATPase regulatory subunit 1	ISS			PTHR10943:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1
P00046	Oxidative stress response	P01131	MKP5	MOUSE|MGI=MGI=1920797|UniProtKB=Q9D9D8	Dual specificity phosphatase 21	TAS			PTHR10159:SF380	DUAL SPECIFICITY PHOSPHATASE 21
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	MACMU|Ensembl=ENSMMUG00000004886|UniProtKB=F7AGT9	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00057	Wnt signaling pathway	P01440	Cadherin	ORNAN|Ensembl=ENSOANG00000007715|UniProtKB=F6UDX0	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF85	CADHERIN-11
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00941	Integrin alpha	MOUSE|MGI=MGI=96600|UniProtKB=Q62469	Integrin alpha-2	IPI	10727440	PubMed	PTHR23220:SF23	INTEGRIN ALPHA-2
P00018	EGF receptor signaling pathway	P00562	p38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00010	B cell activation	P00402	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00052	TGF-beta signaling pathway	P01292	RSmads	MACMU|Ensembl=ENSMMUG00000000340|UniProtKB=F6YMS3	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF36	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5
P00005	Angiogenesis	P00243	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	IC	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CIOIN|Ensembl=ENSCING00000006957|UniProtKB=F6SYL0	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF89	TUBULIN BETA-4 CHAIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	IDA	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00019	Endothelin signaling pathway	P00578	eNOS	BOVIN|Gene=NOS3|UniProtKB=P29473	Nitric oxide synthase, endothelial	IGI	9837777	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05913	Enkephalin release	P05972	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	IDA	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	1170702	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00629	PP2A	XENTR|Xenbase=XB-GENE-484003|UniProtKB=Q6P365	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=1354946|UniProtKB=Q61532	Mitogen-activated protein kinase 6	IC	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	RAT|RGD=70911|UniProtKB=P38444	Activin receptor type-2A	TAS	11252892	PubMed	PTHR23255:SF64	ACTIVIN RECEPTOR TYPE-2A
P00056	VEGF signaling pathway	P01425	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00036	Interleukin signaling pathway	P00965	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IDA	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00972	MNK1/2	BOVIN|Gene=MKNK1|UniProtKB=Q58D94	MAP kinase-interacting serine/threonine-protein kinase 1	ISS	9155017	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IDA	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04397	p53 pathway by glucose deprivation	P04641	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00627	ERK1-2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00775	Rac	ARATH|TAIR=AT5G45970|UniProtKB=Q38903	Rac-like GTP-binding protein ARAC2	TAS			PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00048	PI3 kinase pathway	P01205	NOS	MACMU|Ensembl=ENSMMUG00000020437|UniProtKB=F6WEB2	Nitric oxide synthase	ISS	10435050	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00010	B cell activation	P00385	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	TAS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00029	Huntington disease	P00807	Actin	PHYPA|Gene=PHYPADRAFT_107830|UniProtKB=A9TBG2	Actin 7	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00019	Endothelin signaling pathway	P00585	ECE1-3	CAEEL|WormBase=WBGene00014171|UniProtKB=G5ED52	NEPrilysin metallopeptidase family	ISS			PTHR11733:SF196	NEPRILYSIN METALLOPEPTIDASE FAMILY
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	RAT|RGD=62029|UniProtKB=P02563	Myosin-6	IC	89264452	PubMed	PTHR13140:SF721	MYOSIN-6
P00046	Oxidative stress response	P01135	p38	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	TAS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00372	Grb2	MOUSE|MGI=MGI=1918770|UniProtKB=Q9CX99	GRB2-related adapter protein	ISS			PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	CAEEL|WormBase=WBGene00014095|UniProtKB=Q23621	Glutamate dehydrogenase	ISS			PTHR11606:SF13	GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL
P00053	T cell activation	P01322	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02741	Flavin biosynthesis	P02933	Pyrimidine deaminase	RHOBA|EnsemblGenome=RB6126|UniProtKB=Q7UQS6	Riboflavin bifunctional biosynthesis protein RibG	ISS			PTHR44288:SF1	RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBD
P00004	Alzheimer disease-presenilin pathway	P00147	TACE	HUMAN|HGNC=195|UniProtKB=P78536	Disintegrin and metalloproteinase domain-containing protein 17	TAS	9774383	PubMed	PTHR11905:SF171	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17
P04398	p53 pathway feedback loops 2	P04661	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	ISS	11889139	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00006	Apoptosis signaling pathway	P00292	IkappaB	RAT|RGD=3171|UniProtKB=Q63746	NF-kappa-B inhibitor alpha	ISS	14665694	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P04393	Ras Pathway	P04543	MEKK1/4	RAT|RGD=620966|UniProtKB=Q62925	Mitogen-activated protein kinase kinase kinase 1	IDA	11730323	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00006	Apoptosis signaling pathway	P00292	IkappaB	PANTR|Ensembl=ENSPTRG00000006265|UniProtKB=H2Q867	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	ISS	10811867	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00010	B cell activation	P00397	IKK	PANTR|Ensembl=ENSPTRG00000020202|UniProtKB=H2QW34	Uncharacterized protein	ISS	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P05915	Opioid proenkephalin pathway	P05994	G-protein	MOUSE|MGI=MGI=102705|UniProtKB=P63213	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00029	Huntington disease	P00805	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05961	DOPA decarb.	HUMAN|HGNC=2719|UniProtKB=P20711	Aromatic-L-amino-acid decarboxylase	ISS	107930	OMIM	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00053	T cell activation	P01337	B7	RAT|RGD=2314|UniProtKB=G3V671	CD80 antigen, isoform CRA_a	IDA	1650475	PubMed	PTHR25466:SF4	T-LYMPHOCYTE ACTIVATION ANTIGEN CD80
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	MOUSE|MGI=MGI=88390|UniProtKB=P01216	Glycoprotein hormones alpha chain	ISS	1099091	PubMed	PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00629	PP2A	MOUSE|MGI=MGI=1920180|UniProtKB=Q6ZWR4	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform	ISS	12716901	PubMed	PTHR11871:SF1	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B BETA ISOFORM
P00057	Wnt signaling pathway	P01457	GBeta	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06827	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	RCA	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04393	Ras Pathway	P04570	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	G04714	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00049	Parkinson disease	P01227	20S proteasome	TAKRU|Ensembl=ENSTRUG00000005207|UniProtKB=H2SJC9	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF11	PROTEASOME SUBUNIT ALPHA TYPE-6
P00029	Huntington disease	P00775	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12176041	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	ORNAN|Ensembl=ENSOANG00000014180|UniProtKB=F6PFR5	Fructose-bisphosphate aldolase (Fragment)	ISS	2350361	PubMed	PTHR11627:SF3	FRUCTOSE-BISPHOSPHATE ALDOLASE C
P05918	p38 MAPK pathway	P06034	MKK4	HUMAN|HGNC=6844|UniProtKB=P45985	Dual specificity mitogen-activated protein kinase kinase 4	IDA	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00005	Angiogenesis	P00221	JNK1	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00805	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P05913	Enkephalin release	P05972	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	10218114	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00017	DNA replication	P00527	Histones	CAEBR|Gene=CBG11770|UniProtKB=A8XE06	Histone H3	ISS	12413958	PubMed	PTHR11426:SF118	HISTONE H3.3 TYPE 2-RELATED
P02738	De novo purine biosynthesis	P02889	dGDP kinase	RAT|RGD=619877|UniProtKB=P19804	Nucleoside diphosphate kinase B	ISS			PTHR11349:SF57	NUCLEOSIDE DIPHOSPHATE KINASE B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IDA	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00046	Oxidative stress response	P01129	JNK1/2	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	XENTR|Xenbase=XB-GENE-480347|UniProtKB=Q6P640	Actin, alpha cardiac muscle 1	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00029	Huntington disease	P00776	c-Jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06856	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	RCA	8235613	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00052	TGF-beta signaling pathway	P01284	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ANOGA|EnsemblGenome=AGAP005912|UniProtKB=Q7Q6D3	AGAP005912-PA	IC	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00012	Cadherin signaling pathway	P00464	Fyn	CHICK|Gene=FYN|UniProtKB=Q05876	Tyrosine-protein kinase Fyn	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00005	Angiogenesis	P00205	GAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	ISS	2574500	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	HUMAN|HGNC=4581|UniProtKB=Q13003	Glutamate receptor ionotropic, kainate 3	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00049	Parkinson disease	P01219	SAPK	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	NAS	7600581	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	TAKRU|Ensembl=ENSTRUG00000015938|UniProtKB=H2UUX5	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00029	Huntington disease	P00805	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	SCHPO|PomBase=SPBC32H8.12c|UniProtKB=P10989	Actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CAEEL|WormBase=WBGene00006454|UniProtKB=G5EEN8	AEX-4	IC			PTHR19305:SF10	AEX-4
P00060	Ubiquitin proteasome pathway	P01490	E3	PANTR|Ensembl=ENSPTRG00000009546|UniProtKB=H2QDP6	SMAD specific E3 ubiquitin protein ligase 2	ISS	11252892	PubMed	PTHR11254:SF300	E3 UBIQUITIN-PROTEIN LIGASE SMURF2
P00019	Endothelin signaling pathway	P00591	PLCbeta	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00022	General transcription by RNA polymerase I	P00649	TAF-IC	MOUSE|MGI=MGI=1926879|UniProtKB=Q9EQH4	Transcription initiation factor TFIID subunit 8	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	PANTR|Ensembl=ENSPTRG00000002262|UniProtKB=H2Q1K8	Uncharacterized protein	ISS			PTHR15060:SF0	INTERLEUKIN-15 RECEPTOR SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MACMU|Ensembl=ENSMMUG00000016675|UniProtKB=F6VTB5	Uncharacterized protein	ISS	11319238	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00005	Angiogenesis	P00214	HIF-1	MACMU|Ensembl=ENSMMUG00000021002|UniProtKB=F7HKJ2	Uncharacterized protein	ISS	14526383	PubMed	PTHR23043:SF7	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA
P06587	Nicotine pharmacodynamics pathway	P06595	CHRNA3	MOUSE|MGI=MGI=87887|UniProtKB=Q8R4G9	Neuronal acetylcholine receptor subunit alpha-3	ISS	12098588	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00049	Parkinson disease	P01230	Src kinase	BOVIN|Ensembl=ENSBTAG00000008938|UniProtKB=E1BIM8	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00036	Interleukin signaling pathway	P00974	Receptor subunit beta	HUMAN|HGNC=5971|UniProtKB=P42701	Interleukin-12 receptor subunit beta-1	IC	8958915	PubMed	PTHR23036:SF51	INTERLEUKIN-12 RECEPTOR SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00848	Grb	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	15210125	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04393	Ras Pathway	P04545	Sec5	RAT|RGD=619961|UniProtKB=O54921	Exocyst complex component 2	ISS			PTHR13043:SF1	EXOCYST COMPLEX COMPONENT 2
P00029	Huntington disease	P00778	NMDA receptor	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	IDA	http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P05915	Opioid proenkephalin pathway	P05994	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00047	PDGF signaling pathway	P01148	Grb2	MOUSE|MGI=MGI=1918770|UniProtKB=Q9CX99	GRB2-related adapter protein	ISS	8051109	PubMed	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P00021	FGF signaling pathway	P00628	JNK1-3	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IGI	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00034	Integrin signalling pathway	P00927	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	IGI	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	IDA	9332390	PubMed	PTHR10202:SF13	PRESENILIN-2
P04393	Ras Pathway	P04570	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	ANOGA|EnsemblGenome=AGAP003652|UniProtKB=Q7PQI7	AGAP003652-PA	IC			PTHR11699:SF265	ALDEHYDE DEHYDROGENASE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00640	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	RCA	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05730	Endogenous cannabinoid signaling	P05751	Galpha	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02778	Sulfate assimilation	P03167	Sulfate adenylyltransferase	HUMAN|HGNC=8603|UniProtKB=O43252	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1	ISS			PTHR11055:SF17	BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MOUSE|MGI=MGI=87888|UniProtKB=O70174	Neuronal acetylcholine receptor subunit alpha-4	IC	85270494	PubMed	PTHR18945:SF401	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	IDA	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00059	p53 pathway	P01486	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	TAS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05912	Dopamine receptor mediated signaling pathway	P05970	TH	CHICK|Ensembl=ENSGALG00000006551|UniProtKB=F6RRW6	Uncharacterized protein	ISS	12814656	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P05915	Opioid proenkephalin pathway	P05994	G-protein	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00036	Interleukin signaling pathway	P00996	STAT	BOVIN|Gene=STAT3|UniProtKB=P61635	Signal transducer and activator of transcription 3	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00019	Endothelin signaling pathway	P00577	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00996	STAT	BOVIN|Gene=STAT3|UniProtKB=P61635	Signal transducer and activator of transcription 3	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00056	VEGF signaling pathway	P01413	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04564	MAPKAP	CANLF|Ensembl=ENSCAFG00000011432|UniProtKB=F1PZ82	Uncharacterized protein	ISS			PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00053	T cell activation	P01294	NFAT	RAT|RGD=1307690|UniProtKB=D4A0I8	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (Predicted), isoform CRA_b	ISS	9462517	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	BOVIN|Ensembl=ENSBTAG00000007635|UniProtKB=F1MLS3	Phosphoinositide phospholipase C	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P00050	Plasminogen activating cascade	P01254	pro-MMP-13	RAT|RGD=620196|UniProtKB=P23097	Collagenase 3 (Fragment)	ISS	91093077	PubMed	PTHR10201:SF165	COLLAGENASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_58093|UniProtKB=C3Z4K3	Putative uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P02731	Biotin biosynthesis	P02856	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	METJA|EnsemblGenome=MJ_1300|UniProtKB=Q58696	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	ISS			PTHR42684:SF3	ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	BOVIN|Ensembl=ENSBTAG00000003512|UniProtKB=E1BPX8	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF358	MYOSIN-7B
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	TAS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00023	General transcription regulation	P00660	RNA Polymerase II	DROME|FlyBase=FBgn0033571|UniProtKB=Q7JZF5	RE34924p	ISS	11313498	PubMed	PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P00010	B cell activation	P00381	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00948	Rho	TAKRU|Ensembl=ENSTRUG00000011944|UniProtKB=H2TZX5	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00896	Insulin IGF	HUMAN|HGNC=6081|UniProtKB=P01308	Insulin	ISS			PTHR11454:SF9	INSULIN-RELATED
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00056	VEGF signaling pathway	P01417	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	METAC|EnsemblGenome=MA_2728|UniProtKB=Q8TMD1	Ornithine decarboxylase	ISS			PTHR11482:SF6	ORNITHINE DECARBOXYLASE 1-RELATED
P00010	B cell activation	P00369	MEKK	MOUSE|MGI=MGI=1346873|UniProtKB=Q61083	Mitogen-activated protein kinase kinase kinase 2	IDA	11730323	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	IDA	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00059	p53 pathway	P04615	MTA2	BOVIN|Ensembl=ENSBTAG00000011865|UniProtKB=Q1RMW3	Metastasis associated 1 family, member 2	ISS	11099047	PubMed	PTHR10865:SF4	METASTASIS-ASSOCIATED PROTEIN MTA2
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00046	Oxidative stress response	P01131	MKP5	HUMAN|HGNC=3073|UniProtKB=Q16829	Dual specificity protein phosphatase 7	TAS			PTHR10159:SF305	DUAL SPECIFICITY PROTEIN PHOSPHATASE 7
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g188243|UniProtKB=A7SCN8	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	XENTR|Xenbase=XB-GENE-982496|UniProtKB=F6Z8A1	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00547	PP2A	TAKRU|Ensembl=ENSTRUG00000008018|UniProtKB=H2T5N4	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04657	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01324	rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	IDA	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	PANTR|Ensembl=ENSPTRG00000008766|UniProtKB=H2QC97	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF504	MYOSIN-13
P00016	Cytoskeletal regulation by Rho GTPase	P00521	Profilin	PANTR|Ensembl=ENSPTRG00000015524|UniProtKB=H2QNK5	Profilin	ISS			PTHR13936:SF15	PROFILIN-2
P00057	Wnt signaling pathway	P01470	Frodo	MOUSE|MGI=MGI=1891740|UniProtKB=Q8R4A3	Dapper homolog 1	RCA			PTHR15919:SF12	DAPPER HOMOLOG 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00021	FGF signaling pathway	P00623	FGF	HUMAN|HGNC=3666|UniProtKB=O15520	Fibroblast growth factor 10	ISS	12941620	PubMed	PTHR11486:SF21	FIBROBLAST GROWTH FACTOR 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	CAEEL|WormBase=WBGene00000204|UniProtKB=P58798	Probable actin-related protein 2/3 complex subunit 4	ISS	5031595	gi	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P04397	p53 pathway by glucose deprivation	P04644	TSC2	MACMU|Ensembl=ENSMMUG00000002808|UniProtKB=F7H034	Uncharacterized protein	ISS	15249583	PubMed	PTHR10063:SF0	TUBERIN
P04397	p53 pathway by glucose deprivation	P04647	LKB1	RAT|RGD=1308653|UniProtKB=D4AE59	Serine/threonine-protein kinase STK11	ISS	14985505	PubMed	PTHR44214:SF1	SERINE/THREONINE-PROTEIN KINASE STK11
P00004	Alzheimer disease-presenilin pathway	P00117	E-cadherin C-terminal fragment	XENTR|Xenbase=XB-GENE-482277|UniProtKB=F6QAX3	Uncharacterized protein	ISS	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P00034	Integrin signalling pathway	P00927	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	RAT|RGD=2899|UniProtKB=Q63257	Interleukin-4 receptor subunit alpha	IDA	10525162	PubMed	PTHR23037:SF32	INTERLEUKIN-4 RECEPTOR SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	BOVIN|Ensembl=ENSBTAG00000011757|UniProtKB=Q9XT97	Presenilin-1	TAS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00005	Angiogenesis	P00236	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	ISS			PTHR10048:SF14	PI-3 KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	HUMAN|HGNC=4404|UniProtKB=P59768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IGI	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	GIAIC|EnsemblGenome=GL50803_40817|UniProtKB=A8BV70	Actin related protein	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	PANTR|Ensembl=ENSPTRG00000016293|UniProtKB=H2QPW8	Serine/threonine-protein kinase receptor	ISS	9395284	PubMed	PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P04393	Ras Pathway	P04559	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	15470041	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	ANOGA|EnsemblGenome=AGAP008988|UniProtKB=Q7PWF1	Glutamine synthetase	ISS			PTHR20852:SF44	GLUTAMINE SYNTHETASE 1, MITOCHONDRIAL
P00054	Toll receptor signaling pathway	P01368	MKK2	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05731	GABA-B receptor II signaling	P05752	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	CAEEL|WormBase=WBGene00000295|UniProtKB=Q9GNP0	Uncharacterized protein	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00059	p53 pathway	P04630	PP2A	MOUSE|MGI=MGI=1321159|UniProtKB=P63330	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00054	Toll receptor signaling pathway	P01356	ERK2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04551	RalGDS	HUMAN|HGNC=9769|UniProtKB=O15211	Ral guanine nucleotide dissociation stimulator-like 2	IDA	8939933	PubMed	PTHR23113:SF213	RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 2
P05916	Opioid prodynorphin pathway	P06000	vasopressin	BOVIN|Ensembl=ENSBTAG00000008026|UniProtKB=P01175	Oxytocin-neurophysin 1	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00034	Integrin signalling pathway	P00948	Rho	CHICK|Ensembl=ENSGALG00000001569|UniProtKB=Q9PSX7	Rho-related GTP-binding protein RhoC	ISS	12090470	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IC	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00034	Integrin signalling pathway	P00945	Parvin	MONDO|Ensembl=ENSMODG00000008586|UniProtKB=F7CCU2	Uncharacterized protein	ISS	11331308	PubMed	PTHR12114:SF6	ALPHA-PARVIN
P00045	Notch signaling pathway	G01541	E(spl)-C genes	PANTR|Ensembl=ENSPTRG00000023647|UniProtKB=H2R3T5	Uncharacterized protein	ISS	14973298	PubMed	PTHR10985:SF125	TRANSCRIPTION FACTOR HES-4
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02738	De novo purine biosynthesis	P02891	GDP kinase	DROME|FlyBase=FBgn0000150|UniProtKB=P08879	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00012	Cadherin signaling pathway	P00463	betacatenin	MACMU|Ensembl=ENSMMUG00000014627|UniProtKB=F7GNE4	Catenin beta-1	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00034	Integrin signalling pathway	P00925	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00510	mDia	HUMAN|HGNC=2876|UniProtKB=O60610	Protein diaphanous homolog 1	ISS			PTHR23213:SF17	PROTEIN DIAPHANOUS HOMOLOG 1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IDA	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000014675|UniProtKB=H2QM57	Phosphoinositide phospholipase C	ISS			PTHR10336:SF84	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2
P00005	Angiogenesis	P00256	PLC-gamma	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=2652894|UniProtKB=Q80Y86	Mitogen-activated protein kinase 15	ISS	10514528	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00018	EGF receptor signaling pathway	P00551	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04611	P300	MOUSE|MGI=MGI=1276116|UniProtKB=B2RWS6	Histone acetyltransferase p300	ISS	10823891	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00049	Parkinson disease	P01227	20S proteasome	MOUSE|MGI=MGI=3647964|UniProtKB=D3YX79	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF14	PROTEASOME SUBUNIT ALPHA TYPE-5
P05730	Endogenous cannabinoid signaling	P05748	mGluR	CHICK|Ensembl=ENSGALG00000017238|UniProtKB=F1NWG3	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MONDO|Ensembl=ENSMODG00000013079|UniProtKB=F7FB74	Uncharacterized protein	ISS	1648176	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00059	p53 pathway	P04635	Sumo-1 ligase	PANTR|Ensembl=ENSPTRG00000042199|UniProtKB=H2RG60	Small ubiquitin-related modifier	ISS			PTHR10562:SF11	SMALL UBIQUITIN-RELATED MODIFIER 2-RELATED
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00047	PDGF signaling pathway	P01143	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00018	EGF receptor signaling pathway	P00558	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00021	FGF signaling pathway	P00627	ERK1-2	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01300	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	PANTR|Gene=ALDOA|UniProtKB=A5A6I5	Fructose-bisphosphate aldolase A	ISS	4812352	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00383	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	22533439	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	DROME|FlyBase=FBgn0004647|UniProtKB=P07207	Neurogenic locus Notch protein	IDA	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00055	Transcription regulation by bZIP transcription factor	P01398	TFIIEalpha	CANLF|Ensembl=ENSCAFG00000011306|UniProtKB=E2R3P2	Uncharacterized protein	ISS	189962	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=97438|UniProtKB=P32300	Delta-type opioid receptor	IDA	11259498	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00243	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00269	MAPK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02736	Coenzyme A biosynthesis	P02885	Pantothenate kinase	MOUSE|MGI=MGI=1921700|UniProtKB=Q3U4S0	Pantothenate kinase 2 (Hallervorden-Spatz syndrome)	ISS			PTHR12280:SF25	PANTOTHENATE KINASE 2, MITOCHONDRIAL
P04393	Ras Pathway	P04556	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IDA	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	DANRE|ZFIN=ZDB-GENE-040808-67|UniProtKB=Q6AZA4	K-ras	ISS	20362513	PubMed	PTHR24070:SF186	GTPASE KRAS
P00036	Interleukin signaling pathway	P00981	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00004	Alzheimer disease-presenilin pathway	P00127	APP	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	ORNAN|Ensembl=ENSOANG00000008521|UniProtKB=F6WNA3	Clathrin heavy chain	ISS	9388255	PubMed	PTHR10292:SF7	CLATHRIN HEAVY CHAIN 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	HUMAN|HGNC=6093|UniProtKB=P14616	Insulin receptor-related protein	ISS	6754360	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P02721	ATP synthesis	P02796	F1 gamma	HUMAN|HGNC=833|UniProtKB=P36542	ATP synthase subunit gamma, mitochondrial	ISS	2526651	PubMed	PTHR11693:SF22	ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL
P00029	Huntington disease	P00780	Microtubule	PANTR|Ensembl=ENSPTRG00000017674|UniProtKB=H2Q189	Uncharacterized protein	IDA	9454836	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000013047|UniProtKB=E1BLE8	Uncharacterized protein	ISS	11431030	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MONDO|Ensembl=ENSMODG00000016310|UniProtKB=F7A659	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF31	FRIZZLED-7
P02721	ATP synthesis	P02791	F1 alpha	DANRE|ZFIN=ZDB-GENE-060201-1|UniProtKB=Q08BA1	ATP synthase subunit alpha	ISS	2527557	PubMed	PTHR43089:SF5	ATP SYNTHASE SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01142	p90RSK	CANLF|Ensembl=ENSCAFG00000012413|UniProtKB=E2RR13	Uncharacterized protein	ISS			PTHR15508:SF2	RIBOSOMAL PROTEIN S6 KINASE DELTA-1
P00049	Parkinson disease	P01230	Src kinase	RAT|RGD=1308800|UniProtKB=P32577	Tyrosine-protein kinase CSK	ISS	11078745	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	XENTR|Xenbase=XB-GENE-941426|UniProtKB=Q28HZ4	Novel Rho protein	ISS	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	TAS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00053	T cell activation	P01330	IKK	MACMU|Ensembl=ENSMMUG00000018476|UniProtKB=F6X938	Uncharacterized protein	ISS	14499113	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P05918	p38 MAPK pathway	P06013	ELK	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	RCA	3183861	gi	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00034	Integrin signalling pathway	P00922	Collagen	CHICK|Gene=COL6A1|UniProtKB=P20785	Collagen alpha-1(VI) chain	IDA	10778855	PubMed	PTHR44172:SF3	COLLAGEN ALPHA-1 VI  CHAIN
P00019	Endothelin signaling pathway	P00589	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00053	T cell activation	P01312	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IDA	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00053	T cell activation	P01335	jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05923	beta-ARR2	HUMAN|HGNC=712|UniProtKB=P32121	Beta-arrestin-2	RCA	9388255	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	TAS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	RAT|RGD=2738|UniProtKB=Q00960	Glutamate receptor ionotropic, NMDA 2B	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P06664	Gonadotropin-releasing hormone receptor pathway	P06769	Gbeta	MOUSE|MGI=MGI=101848|UniProtKB=P62881	Guanine nucleotide-binding protein subunit beta-5	RCA	9754712	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00034	Integrin signalling pathway	P00912	Arp2/3	ORNAN|Ensembl=ENSOANG00000007724|UniProtKB=F6QTB5	Uncharacterized protein	ISS	12473693	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00057	Wnt signaling pathway	P01440	Cadherin	MONDO|Ensembl=ENSMODG00000003756|UniProtKB=F7AAP1	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF96	CADHERIN-12
P00029	Huntington disease	P00774	Dynein complex	SCHMA|EnsemblGenome=Smp_201060|UniProtKB=G4V854	Putative uncharacterized protein Smp_201060	IPI	9454836	PubMed	PTHR11886:SF62	DYNEIN, LIGHT CHAIN, LC8-TYPE 2
P00052	TGF-beta signaling pathway	P01284	JNK	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	DROME|FlyBase=FBgn0004647|UniProtKB=P07207	Neurogenic locus Notch protein	IDA	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	7925653	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P05731	GABA-B receptor II signaling	P05752	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	TAKRU|Ensembl=ENSTRUG00000014690|UniProtKB=H2UKR9	Uncharacterized protein	IDA	12181435	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	RAT|RGD=3140|UniProtKB=Q62812	Myosin-9	ISS	89264452	PubMed	PTHR13140:SF317	MYOSIN-9
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000016815|UniProtKB=F7C9S6	Uncharacterized protein	ISS	12562507	PubMed	PTHR24229:SF52	SOMATOSTATIN RECEPTOR TYPE 4
P00057	Wnt signaling pathway	P01451	Galpha	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	IDA	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00010	B cell activation	P00391	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01236	Casein kinase II	MOUSE|MGI=MGI=88547|UniProtKB=O54833	Casein kinase II subunit alpha'	IDA	10806215	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P04393	Ras Pathway	P04570	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00060	Ubiquitin proteasome pathway	P01491	E2	XENTR|Xenbase=XB-GENE-954784|UniProtKB=A0JM78	Ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog)	ISS			PTHR24068:SF36	UBIQUITIN-CONJUGATING ENZYME E2 D1
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	CHICK|Ensembl=ENSGALG00000002859|UniProtKB=F6UBD2	Uncharacterized protein	ISS			PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05731	GABA-B receptor II signaling	P05753	Ca channel	BOVIN|Ensembl=ENSBTAG00000014828|UniProtKB=F1N1E0	Uncharacterized protein	ISS	11976940	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MOUSE|MGI=MGI=95777|UniProtKB=Q6R0H7	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas	ISS	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	ORNAN|Ensembl=ENSOANG00000005566|UniProtKB=F6PZT8	Uncharacterized protein	ISS			PTHR11454:SF4	INSULIN-LIKE GROWTH FACTOR I
P02779	Thiamin biosynthesis	P03173	Thiamin phosphate synthase	AQUAE|EnsemblGenome=aq_558|UniProtKB=O66833	Thiamine-phosphate synthase 1	ISS			PTHR20857:SF15	THIAMINE BIOSYNTHETIC BIFUNCTIONAL ENZYME
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	MOUSE|MGI=MGI=88459|UniProtKB=Q04857	Collagen alpha-1(VI) chain	IDA	10727440	PubMed	PTHR44172:SF3	COLLAGEN ALPHA-1 VI  CHAIN
P00005	Angiogenesis	P00238	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	HUMAN|HGNC=8568|UniProtKB=P09958	Furin	IDA	95328031	PubMed	PTHR42884:SF1	FURIN
P00053	T cell activation	P01307	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00047	PDGF signaling pathway	P01173	STAT	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	BOVIN|Ensembl=ENSBTAG00000009175|UniProtKB=E1BLQ5	Uncharacterized protein	ISS	15116068	PubMed	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	RCA	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00049	Parkinson disease	P01211	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IC	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04393	Ras Pathway	P04541	p90RSK	MOUSE|MGI=MGI=104557|UniProtKB=P18654	Ribosomal protein S6 kinase alpha-3	IDA	6755374	gi	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8680|UniProtKB=Q9Y5F3	Protocadherin beta-1	IDA	8120095	PubMed	PTHR24028:SF12	PROTOCADHERIN BETA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00029	Huntington disease	P00796	Kainate receptor	MONDO|Ensembl=ENSMODG00000018065|UniProtKB=F7G485	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P06959	CCKR signaling map	G07266	FOS	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	RCA	12239223	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00045	Notch signaling pathway	P01104	Serrate	MACMU|Ensembl=ENSMMUG00000018116|UniProtKB=F7FGM9	Delta-like protein	ISS	1286675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	TAS	9860142	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	ENTHI|EnsemblGenome=EHI_137700|UniProtKB=Q24806	Ras family GTPase	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	MACMU|Ensembl=ENSMMUG00000021075|UniProtKB=F7GY91	Uncharacterized protein	ISS			PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00057	Wnt signaling pathway	P01471	alpha-catenin	CANLF|Ensembl=ENSCAFG00000001315|UniProtKB=E2R9S7	Uncharacterized protein	ISS	9362521	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00005	Angiogenesis	P00223	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00238	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00029	Huntington disease	P00790	beta-Tubulin	SCHMA|EnsemblGenome=Smp_078040|UniProtKB=C4QIC0	Tubulin beta chain,putative	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00005	Angiogenesis	P00237	FRP	PANTR|Ensembl=ENSPTRG00000028511|UniProtKB=H2R570	Uncharacterized protein	ISS	12549854	PubMed	PTHR11309:SF81	FRIZZLED-1
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00543	ERK1-2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01419	Ets	MOUSE|MGI=MGI=95455|UniProtKB=P27577	Protein C-ets-1	ISS	15579511	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	MOUSE|MGI=MGI=1346037|UniProtKB=Q9WTL4	Insulin receptor-related protein	ISS	12644000	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	MOUSE|MGI=MGI=109284|UniProtKB=Q61144	Presenilin-2	IDA	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00036	Interleukin signaling pathway	P00977	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IC	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00035	Interferon-gamma signaling pathway	P00960	PTP	DROME|FlyBase=FBgn0000382|UniProtKB=P29349	Tyrosine-protein phosphatase corkscrew	TAS	14525967	PubMed	PTHR19134:SF428	TYROSINE-PROTEIN PHOSPHATASE CORKSCREW
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	EMENI|EnsemblGenome=CADANIAG00002670|UniProtKB=Q5BH99	G-protein beta subunit [Source:UniProtKB/TrEMBLAcc:O74214]	IC	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000019361|UniProtKB=H2QUV3	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MACMU|Ensembl=ENSMMUG00000017345|UniProtKB=F7H9C0	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	BOVIN|Ensembl=ENSBTAG00000018445|UniProtKB=E1BK87	Uncharacterized protein	ISS	11319238	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00004	Alzheimer disease-presenilin pathway	P00114	actin	SCHMA|EnsemblGenome=Smp_161920|UniProtKB=G4VSW5	Putative actin	IDA	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DANRE|ZFIN=ZDB-GENE-040426-1354|UniProtKB=Q7T2C5	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00018	EGF receptor signaling pathway	P00560	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01303	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12748278	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00053	T cell activation	P01319	PAK	BOVIN|Ensembl=ENSBTAG00000047856|UniProtKB=G3MZE2	Uncharacterized protein	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00010	B cell activation	P00398	IP3R	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	IGI	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04393	Ras Pathway	P04578	Rho	PANTR|Ensembl=ENSPTRG00000040414|UniProtKB=H2RH27	Ras homolog gene family, member B	ISS	11973360	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IC	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00006	Apoptosis signaling pathway	P00273	p53	MACMU|Ensembl=ENSMMUG00000008639|UniProtKB=P56424	Cellular tumor antigen p53	ISS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P04393	Ras Pathway	P04555	PDK	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	12855688	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CAEBR|Gene=CBG23091|UniProtKB=A8Y4Q9	Protein CBR-ACT-2	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	CANLF|Ensembl=ENSCAFG00000004090|UniProtKB=F1PNQ0	Uncharacterized protein	ISS	2255909	PubMed	PTHR11920:SF291	ADENYLATE CYCLASE TYPE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00507	Rho	MOUSE|MGI=MGI=106028|UniProtKB=Q62159	Rho-related GTP-binding protein RhoC	ISS	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00021	FGF signaling pathway	P00646	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00048	PI3 kinase pathway	P01179	PKB	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	TAS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01129	JNK1/2	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00011	Blood coagulation	P00443	Fibrin polymer cross-linked	MACMU|Ensembl=ENSMMUG00000021304|UniProtKB=F6UYY8	Uncharacterized protein	ISS	223170	gi	PTHR19143:SF338	FIBRINOGEN GAMMA CHAIN
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00057	Wnt signaling pathway	P01438	PP2A	ORNAN|Ensembl=ENSOANG00000009097|UniProtKB=F7G755	Uncharacterized protein	ISS	11007767	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00057	Wnt signaling pathway	P01438	PP2A	RAT|RGD=6503746|UniProtKB=Q80W83	Protein LOC100909468	ISS	96161994	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	CAEEL|WormBase=WBGene00001612|UniProtKB=P34299	Glutamate receptor 1	ISS	12941441	PubMed	PTHR18966:SF297	GLUTAMATE RECEPTOR 1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P06959	CCKR signaling map	P07223	Signal-pre-pro CCK	HUMAN|HGNC=1569|UniProtKB=P06307	Cholecystokinin	RCA	12479974	PubMed	PTHR10786:SF0	CHOLECYSTOKININ
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01070	K+ channel	HUMAN|HGNC=6296|UniProtKB=O43526	Potassium voltage-gated channel subfamily KQT member 2	ISS	12223552	PubMed	PTHR11537:SF6	POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 2
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	MOUSE|MGI=MGI=1346877|UniProtKB=Q62073	Mitogen-activated protein kinase kinase kinase 7	IDA	10683140	PubMed	PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P00029	Huntington disease	P00778	NMDA receptor	CAEBR|Gene=CBG02401|UniProtKB=A8WUE7	Protein CBR-NMR-1	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00036	Interleukin signaling pathway	P00976	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	IDA	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P06959	CCKR signaling map	P07145	Paxillin	HUMAN|HGNC=9718|UniProtKB=P49023	Paxillin	RCA	21224360	PubMed	PTHR24216:SF11	PAXILLIN
P02769	Purine metabolism	P03116	Xanthine Oxidase	PANTR|Ensembl=ENSPTRG00000011806|UniProtKB=H2QHQ2	Uncharacterized protein	ISS	8135849	PubMed	PTHR11908:SF80	XANTHINE DEHYDROGENASE/OXIDASE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	8787761	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P05915	Opioid proenkephalin pathway	P05994	G-protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00029	Huntington disease	P00797	p53	HUMAN|HGNC=15979|UniProtKB=Q9H3D4	Tumor protein 63	TAS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00003	Alzheimer disease-amyloid secretase pathway	P00095	Nicastrin	CANLF|Ensembl=ENSCAFG00000012557|UniProtKB=F1PU73	Uncharacterized protein	ISS	16096062	PubMed	PTHR21092:SF0	NICASTRIN
P00018	EGF receptor signaling pathway	P00541	Spry	XENTR|Xenbase=XB-GENE-482101|UniProtKB=Q5Y173	Sprouty2	ISS	21231191	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00001	Adrenaline and noradrenaline biosynthesis	P00071	VAT1	CAEEL|WormBase=WBGene00000295|UniProtKB=Q9GNP0	Uncharacterized protein	ISS			PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P06664	Gonadotropin-releasing hormone receptor pathway	P06852	nPKCs	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04393	Ras Pathway	P04570	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00977	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P04398	p53 pathway feedback loops 2	P04657	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=94924|UniProtKB=P61168	D(2) dopamine receptor	IDA	2039532	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00018	EGF receptor signaling pathway	P00551	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00060	Ubiquitin proteasome pathway	P01492	E1	MACMU|Ensembl=ENSMMUG00000003776|UniProtKB=F7GVQ5	Uncharacterized protein	ISS			PTHR10953:SF186	UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 6
P04395	Vasopressin synthesis	P04597	Signal Peptide	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	MOUSE|MGI=MGI=1339975|UniProtKB=O88643	Serine/threonine-protein kinase PAK 1	ISS	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P05731	GABA-B receptor II signaling	P05754	Ggamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00578	eNOS	MOUSE|MGI=MGI=97362|UniProtKB=P70313	Nitric oxide synthase, endothelial	IGI	22462730	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	MACMU|Ensembl=ENSMMUG00000014498|UniProtKB=F7GEI8	Uncharacterized protein	ISS	14624853	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00007	Axon guidance mediated by semaphorins	P00340	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	10891487	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P06959	CCKR signaling map	P07037	PLCgamma1	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	RCA	15196926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00006	Apoptosis signaling pathway	P00260	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	XENTR|Xenbase=XB-GENE-491618|UniProtKB=Q6P378	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00049	Parkinson disease	P01219	SAPK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00049	Parkinson disease	P01208	Hsp70	TAKRU|Ensembl=ENSTRUG00000007906|UniProtKB=H2T4V1	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00036	Interleukin signaling pathway	P00974	Receptor subunit beta	MOUSE|MGI=MGI=109380|UniProtKB=Q61190	Interleukin-10 receptor subunit beta	IDA	9463407	PubMed	PTHR20859:SF50	INTERLEUKIN-10 RECEPTOR SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	IDA	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BOVIN|Ensembl=ENSBTAG00000014614|UniProtKB=P62739	Actin, aortic smooth muscle	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00057	Wnt signaling pathway	P01457	GBeta	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IDA	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04558	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IGI	10644715	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P06664	Gonadotropin-releasing hormone receptor pathway	P06705	PLCbeta	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	RCA	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00037	Ionotropic glutamate receptor pathway	P01026	KA	DANRE|Ensembl=ENSDARG00000070511|UniProtKB=E7F5R2	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF282	GLUTAMATE RECEPTOR-RELATED
P00054	Toll receptor signaling pathway	P01380	TLR1,2,6	MOUSE|MGI=MGI=1341295|UniProtKB=Q9EPQ1	Toll-like receptor 1	ISS			PTHR24365:SF261	TOLL-LIKE RECEPTOR 1
P05734	Synaptic vesicle trafficking	P05776	RIM1alpha/2alpha	MACMU|Ensembl=ENSMMUG00000019407|UniProtKB=F6RH55	Uncharacterized protein	ISS			PTHR12157:SF15	REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000012822|UniProtKB=F6PX40	Phosphoinositide phospholipase C	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00057	Wnt signaling pathway	P01472	Histone deacetylase	STRPU|EnsemblGenome=SPU_008768|UniProtKB=P56518	Histone deacetylase 1	IDA	10485845	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	PANTR|Ensembl=ENSPTRG00000024129|UniProtKB=H2R176	Uncharacterized protein	ISS			PTHR10937:SF2	GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE  ISOMERIZING  1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00049	Parkinson disease	P01242	Casein kinase I	DANRE|ZFIN=ZDB-GENE-030131-825|UniProtKB=Q7T2E3	Casein kinase I isoform delta-A	ISS	11437445	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	HUMAN|HGNC=16767|UniProtKB=Q8TCU5	Glutamate receptor ionotropic, NMDA 3A	ISS	11319238	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00049	Parkinson disease	P01242	Casein kinase I	LEIMA|EnsemblGenome=LmjF.35.1000|UniProtKB=Q9NHE2	Casein kinase 1 isoform 1	IDA	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04565	MKK4/7	BOVIN|Ensembl=ENSBTAG00000012103|UniProtKB=A5PJP8	MAP2K4 protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00015	Circadian clock system	P00505	Cry	ARATH|TAIR=AT1G04400|UniProtKB=Q96524	Cryptochrome-2	ISS			PTHR11455:SF44	CRYPTOCHROME-2
P00006	Apoptosis signaling pathway	P00269	MAPK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00030	Hypoxia response via HIF activation	P00824	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00021	FGF signaling pathway	P00629	PP2A	DANRE|ZFIN=ZDB-GENE-040426-2487|UniProtKB=Q803G3	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00011	Blood coagulation	P00413	HMWK	HUMAN|HGNC=6383|UniProtKB=P01042	Kininogen-1	ISS	386852	gi	PTHR13814:SF12	KININOGEN-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00029	Huntington disease	P00805	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04398	p53 pathway feedback loops 2	P04651	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	87226391	PubMed	PTHR24070:SF385	GTPASE HRAS
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	HUMAN|HGNC=1389|UniProtKB=Q00975	Voltage-dependent N-type calcium channel subunit alpha-1B	IDA	15079861	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00012	Cadherin signaling pathway	P00470	F-actin	TRIVA|Gene=TVAG_337240|UniProtKB=P90623	Actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	IC	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00051	TCA cycle	P01271	Fumarase	YEAST|SGD=S000006183|UniProtKB=P08417	Fumarate hydratase, mitochondrial	IDA	87308235	PubMed	PTHR11444:SF1	FUMARATE HYDRATASE, MITOCHONDRIAL
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00271	Bax	XENTR|Xenbase=XB-GENE-486067|UniProtKB=Q6P4Y4	BCL2-associated X protein	ISS	14963330	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00019	Endothelin signaling pathway	P00591	PLCbeta	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00030	Hypoxia response via HIF activation	P00823	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	PANTR|Ensembl=ENSPTRG00000000499|UniProtKB=H2PYL4	Adenylate kinase 2, mitochondrial	ISS			PTHR23359:SF117	ADENYLATE KINASE 2, MITOCHONDRIAL
P00036	Interleukin signaling pathway	P00996	STAT	CANLF|Ensembl=ENSCAFG00000015213|UniProtKB=E2RB82	Signal transducer and activator of transcription	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	MOUSE|MGI=MGI=2443973|UniProtKB=Q8K1L0	Cyclic AMP-responsive element-binding protein 5	RCA			PTHR19304:SF8	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 5
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	RAT|RGD=1306620|UniProtKB=B1H230	Map2k3 protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00010	B cell activation	P00384	p38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	CAEEL|WormBase=WBGene00002191|UniProtKB=P18334	Casein kinase II subunit alpha	IDA	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P06664	Gonadotropin-releasing hormone receptor pathway	G06678	FSHbeta	MOUSE|MGI=MGI=95582|UniProtKB=Q60687	Follitropin subunit beta	RCA			PTHR11515:SF17	FOLLITROPIN SUBUNIT BETA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00005	Angiogenesis	P00206	Wnt	BOVIN|Ensembl=ENSBTAG00000009217|UniProtKB=F1MEW8	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05731	GABA-B receptor II signaling	P05760	AC	MOUSE|MGI=MGI=102891|UniProtKB=P51829	Adenylate cyclase type 7	RCA	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00047	PDGF signaling pathway	P01161	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00859	NFkappaB	MOUSE|MGI=MGI=103290|UniProtKB=Q04207	Transcription factor p65	RCA			PTHR24169:SF1	TRANSCRIPTION FACTOR P65
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	MACMU|Ensembl=ENSMMUG00000011741|UniProtKB=F7GWY8	Synaptotagmin XII	ISS			PTHR10024:SF252	SYNAPTOTAGMIN-12
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	IDA	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00046	Oxidative stress response	P01138	MKK4	HUMAN|HGNC=6844|UniProtKB=P45985	Dual specificity mitogen-activated protein kinase kinase 4	TAS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00057	Wnt signaling pathway	P01465	Ggamma	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00018	EGF receptor signaling pathway	P00539	14-3-3	PANTR|Ensembl=ENSPTRG00000019320|UniProtKB=H2QUT2	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	ISS	10407019	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P05915	Opioid proenkephalin pathway	P05994	G-protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00111	C99	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00056	VEGF signaling pathway	P01408	Akt/PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00005	Angiogenesis	P00193	SOS-1	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	CHICK|Ensembl=ENSGALG00000017238|UniProtKB=F1NWG3	Uncharacterized protein	ISS	92317054	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P04398	p53 pathway feedback loops 2	P04663	Mdm2	BOVIN|Ensembl=ENSBTAG00000010422|UniProtKB=F1MYE6	Uncharacterized protein	ISS	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00015	Circadian clock system	G01501	cry	ORNAN|Ensembl=ENSOANG00000005350|UniProtKB=F6X852	Uncharacterized protein	ISS	11533252	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00025	Hedgehog signaling pathway	P00682	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	TAS	176948	OMIM	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00798	Clathrin	BOVIN|Ensembl=ENSBTAG00000001137|UniProtKB=P04973	Clathrin light chain A	IDA	9388255	PubMed	PTHR10639:SF1	CLATHRIN LIGHT CHAIN A
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02785	Valine biosynthesis	P03215	Branched chain amino acid aminotransferase	CAEEL|WormBase=WBGene00012855|UniProtKB=Q9XXD8	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF28	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P02741	Flavin biosynthesis	P02936	FAD synthetase	MACMU|Ensembl=ENSMMUG00000006584|UniProtKB=F7HPM8	Uncharacterized protein	RCA			PTHR23293:SF9	FAD SYNTHASE
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000008269|UniProtKB=H2QBE4	Cadherin 3, type 1, P-cadherin (Placental)	ISS	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P00005	Angiogenesis	P00223	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02738	De novo purine biosynthesis	P02898	Phosphoribosylformylglycinamide  synthase	MOUSE|MGI=MGI=2684864|UniProtKB=Q5SUR0	Phosphoribosylformylglycinamidine synthase	ISS			PTHR10099:SF1	PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE
P00046	Oxidative stress response	P01135	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	MACMU|Ensembl=ENSMMUG00000010173|UniProtKB=F7AGU8	Presenilin	ISS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00019	Endothelin signaling pathway	P00590	IP3 R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000014674|UniProtKB=P41985	Muscarinic acetylcholine receptor M2	ISS	10069496	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P05912	Dopamine receptor mediated signaling pathway	P05963	MAO	RAT|RGD=61898|UniProtKB=P21396	Amine oxidase [flavin-containing] A	ISS	90344230	PubMed	PTHR43563:SF3	AMINE OXIDASE  FLAVIN-CONTAINING  A
P00054	Toll receptor signaling pathway	P01375	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	RAT|RGD=3275|UniProtKB=Q62849	Proprotein convertase subtilisin/kexin type 7	IDA			PTHR42884:SF12	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 7
P00046	Oxidative stress response	P01129	JNK1/2	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00034	Integrin signalling pathway	P00922	Collagen	HUMAN|HGNC=2202|UniProtKB=P02462	Collagen alpha-1(IV) chain	IDA	10778855	PubMed	PTHR24023:SF854	COLLAGEN ALPHA-1 IV  CHAIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CAEEL|WormBase=WBGene00003515|UniProtKB=P12844	Myosin-3	IC			PTHR13140:SF446	MYOSIN-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PHYIT|EnsemblGenome=PITG_06376|UniProtKB=D0N4Q3	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta, putative	IC	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00056	VEGF signaling pathway	P01408	Akt/PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00564	Rac	DICDI|dictyBase=DDB_G0293526|UniProtKB=P34149	Rho-related protein racC	IGI	94124042	PubMed	PTHR24072:SF117	RHO-RELATED PROTEIN RACC
P00056	VEGF signaling pathway	P01414	PLC-gamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04397	p53 pathway by glucose deprivation	P04636	S6K	PANTR|Ensembl=ENSPTRG00000003957|UniProtKB=H2Q486	Ribosomal protein S6 kinase	ISS	15116068	PubMed	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	CHLRE|EnsemblGenome=CHLREDRAFT_184001|UniProtKB=A8IV67	26S proteasome regulatory subunit	ISS			PTHR23073:SF13	26S PROTEASE REGULATORY SUBUNIT 7
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P02754	Methylcitrate cycle	P03028	Aconitase	ANOGA|EnsemblGenome=AGAP007258|UniProtKB=Q7PTD5	Aconitate hydratase	ISS			PTHR11670:SF1	ACONITATE HYDRATASE
P00011	Blood coagulation	P00443	Fibrin polymer cross-linked	HUMAN|HGNC=3662|UniProtKB=P02675	Fibrinogen beta chain	ISS	223002	gi	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	MACMU|Ensembl=ENSMMUG00000013566|UniProtKB=F7FMI1	Uncharacterized protein	ISS	11163236	PubMed	PTHR20859:SF21	INTERLEUKIN-20 RECEPTOR SUBUNIT ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05934	ELK1	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	11279280	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00010	B cell activation	P00369	MEKK	PANTR|Ensembl=ENSPTRG00000012427|UniProtKB=H2QIN7	Mitogen-activated protein kinase kinase kinase 2	ISS	21735556	gi	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00029	Huntington disease	P00768	Apaf-1	HUMAN|HGNC=576|UniProtKB=O14727	Apoptotic protease-activating factor 1	TAS	10364241	PubMed	PTHR22845:SF5	APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
P00006	Apoptosis signaling pathway	P00269	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00057	Wnt signaling pathway	P01452	NFAT	RAT|RGD=1310749|UniProtKB=D3Z9H7	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	ISS	12787506	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1203729|UniProtKB=Q61194	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	IPI	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P04393	Ras Pathway	P04570	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00018	EGF receptor signaling pathway	P00564	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	XENTR|Xenbase=XB-GENE-481916|UniProtKB=F6YF14	Presenilin	ISS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00056	VEGF signaling pathway	P01423	p38MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00623	FGF	RAT|RGD=620129|UniProtKB=P48807	Fibroblast growth factor 5	ISS	9786939	PubMed	PTHR11486:SF23	FIBROBLAST GROWTH FACTOR 5
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00036	Interleukin signaling pathway	P00975	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	2574500	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00023	General transcription regulation	P00658	TBP-associated factors	ARATH|TAIR=AT1G04950|UniProtKB=Q9MAU3	Transcription initiation factor TFIID subunit 6	ISS	15220358	gi	PTHR10221:SF13	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00056	VEGF signaling pathway	P01420	FAK	CAEEL|WormBase=WBGene00002213|UniProtKB=Q95YD4	Inactive tyrosine-protein kinase kin-32	ISS			PTHR24418:SF367	FOCAL ADHESION KINASE, ISOFORM D
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	HUMAN|HGNC=4571|UniProtKB=P42261	Glutamate receptor 1	ISS	12871085	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00056	VEGF signaling pathway	P01413	PI3K	XENTR|Xenbase=XB-GENE-6067221|UniProtKB=F6Z0J4	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00021	FGF signaling pathway	P00638	PLCgamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01154	Ras	MONDO|Gene=KRAS|UniProtKB=Q07983	GTPase KRas	ISS	3023884	PubMed	PTHR24070:SF186	GTPASE KRAS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00899	IRS 1-4	MOUSE|MGI=MGI=99454|UniProtKB=P35569	Insulin receptor substrate 1	ISS	5031805	gi	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PUCGT|EnsemblGenome=PGTG_05488|UniProtKB=E3K4I1	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00468	Src	CANLF|Ensembl=ENSCAFG00000008755|UniProtKB=E2RSH8	Tyrosine-protein kinase	ISS	8054685	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00049	Parkinson disease	P01211	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00054	Toll receptor signaling pathway	P01370	TAK1	RAT|RGD=1309438|UniProtKB=P0C8E4	Mitogen-activated protein kinase kinase kinase 7	ISS	10683140	PubMed	PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P05731	GABA-B receptor II signaling	P05760	AC	CHICK|Gene=ADCY9|UniProtKB=Q9DGG6	Adenylate cyclase type 9	RCA	21222856	PubMed	PTHR11920:SF319	ADENYLATE CYCLASE TYPE 9
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04556	Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	IDA	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00034	Integrin signalling pathway	P00927	Rac	ENTHI|EnsemblGenome=EHI_181250|UniProtKB=C4M5Z7	Rho family GTPase	IGI	12932731	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P02775	Salvage pyrimidine ribonucleotides	P03151	Uracil phosphoribosyl  transferase	ORNAN|Ensembl=ENSOANG00000005514|UniProtKB=F6X611	Uncharacterized protein	ISS			PTHR10285:SF90	URACIL PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01407	Erk	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00321	HSP70	ORYSJ|EnsemblGenome=OS02G0115900|UniProtKB=Q6Z7B0	Dnak-type molecular chaperone Bip	ISS	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00046	Oxidative stress response	P01135	p38	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00022	General transcription by RNA polymerase I	P00657	TBP	PANTR|Ensembl=ENSPTRG00000018827|UniProtKB=H2RD22	Uncharacterized protein	ISS	600075	OMIM	PTHR10126:SF20	TATA-BOX-BINDING PROTEIN
P00012	Cadherin signaling pathway	P00470	F-actin	DICDI|dictyBase=DDB_G0269234|UniProtKB=P07830	Major actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04393	Ras Pathway	P04567	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	IDA	12660731	PubMed	PTHR10048:SF14	PI-3 KINASE
P00029	Huntington disease	P00786	ARF	PANTR|Ensembl=ENSPTRG00000019651|UniProtKB=H2QVB1	ADP-ribosylation factor 5	ISS	12932731	PubMed	PTHR11711:SF307	ADP-RIBOSYLATION FACTOR 5
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	IDA	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	BOVIN|Ensembl=ENSBTAG00000033153|UniProtKB=F1MG21	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00056	VEGF signaling pathway	P01411	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P05915	Opioid proenkephalin pathway	P05994	G-protein	MOUSE|MGI=MGI=1336171|UniProtKB=Q9DAS9	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00018	EGF receptor signaling pathway	P00543	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	18479080	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00047	PDGF signaling pathway	P01167	Ets	CHICK|Ensembl=ENSGALG00000001161|UniProtKB=E1BVB4	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF161	FRIEND LEUKEMIA INTEGRATION 1 TRANSCRIPTION FACTOR
P00004	Alzheimer disease-presenilin pathway	P00131	HAC1	PANTR|Ensembl=ENSPTRG00000016522|UniProtKB=H2R245	Uncharacterized protein	ISS			PTHR44028:SF2	TRIPARTITE MOTIF-CONTAINING PROTEIN 2
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00629	PP2A	MOUSE|MGI=MGI=2388479|UniProtKB=Q6PD03	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform	ISS	12110603	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF31	SUBFAMILY NOT NAMED
P02723	Adenine and hypoxanthine salvage pathway	P02805	Adenine phosphorylase	BACSU|EnsemblGenome=BSU23490|UniProtKB=P46354	Purine nucleoside phosphorylase 1	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00060	Ubiquitin proteasome pathway	P01491	E2	CHICK|Ensembl=ENSGALG00000028133|UniProtKB=Q5F3Z3	Ubiquitin-conjugating enzyme E2 variant 2	ISS			PTHR43915:SF3	UBIQUITIN-CONJUGATING ENZYME E2 VARIANT 2
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01440	Cadherin	BOVIN|Ensembl=ENSBTAG00000037844|UniProtKB=Q08DJ5	Cadherin-18	ISS	8120095	PubMed	PTHR24027:SF106	CADHERIN-18
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	CANLF|Ensembl=ENSCAFG00000010529|UniProtKB=F1PUS1	Uncharacterized protein	ISS			PTHR42884:SF8	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 6
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	DICDI|dictyBase=DDB_G0269196|UniProtKB=P32256	Tubulin beta chain	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00049	Parkinson disease	P01236	Casein kinase II	XENTR|Xenbase=XB-GENE-487069|UniProtKB=F6RN85	Uncharacterized protein	ISS	10806215	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00030	Hypoxia response via HIF activation	P00819	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_115565|UniProtKB=C3XYD3	Putative uncharacterized protein	ISS			PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00036	Interleukin signaling pathway	P00973	PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1712|UniProtKB=Q6PBY0	Guanine nucleotide binding protein (G protein), beta 5	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176910	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	MOUSE|MGI=MGI=1202876|UniProtKB=Q9Z1J1	Transcription factor 7-like 1	TAS	12356903	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P02738	De novo purine biosynthesis	P02889	dGDP kinase	CHICK|Ensembl=ENSGALG00000002932|UniProtKB=O57535	Nucleoside diphosphate kinase	ISS			PTHR11349:SF57	NUCLEOSIDE DIPHOSPHATE KINASE B
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05912	Dopamine receptor mediated signaling pathway	P05970	TH	TAKRU|Ensembl=ENSTRUG00000009267|UniProtKB=A0JGX6	Tyrosine 3-monooxygenase	ISS	12814656	PubMed	PTHR11473:SF34	TYROSINE HYDROXYLASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	TAS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	DROME|FlyBase=FBgn0026059|UniProtKB=Q8INC3	Myosin heavy chain-like, isoform B	IC			PTHR13140:SF696	MYOSIN HEAVY CHAIN-LIKE, ISOFORM B
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	MOUSE|MGI=MGI=1351338|UniProtKB=P97772	Metabotropic glutamate receptor 1	IC	8314195	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00018	EGF receptor signaling pathway	P00562	p38	DROME|FlyBase=FBgn0015765|UniProtKB=O62618	Mitogen-activated protein kinase 14A	IGI	9417090	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00221	JNK1	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000013587|UniProtKB=F7AZ16	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF33	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-3
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=94924|UniProtKB=P61168	D(2) dopamine receptor	IDA	11248120	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00057	Wnt signaling pathway	P01438	PP2A	MONDO|Ensembl=ENSMODG00000019007|UniProtKB=F7C5Z9	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00054	Toll receptor signaling pathway	P01373	CD14	MACMU|Ensembl=ENSMMUG00000010007|UniProtKB=B3Y6B8	Monocyte differentiation antigen CD14	ISS			PTHR10630:SF3	MONOCYTE DIFFERENTIATION ANTIGEN CD14
P00005	Angiogenesis	P00219	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00223	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00025	Hedgehog signaling pathway	P00682	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00633	Ras	CHICK|Ensembl=ENSGALG00000014033|UniProtKB=E1BTS2	Uncharacterized protein	ISS	9869449	PubMed	PTHR24070:SF186	GTPASE KRAS
P00034	Integrin signalling pathway	P00948	Rho	XENTR|Xenbase=XB-GENE-941426|UniProtKB=Q28HZ4	Novel Rho protein	ISS	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	DROME|FlyBase=FBgn0019947|UniProtKB=O02194	Presenilin homolog	TAS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00006	Apoptosis signaling pathway	P00257	Bcl-xL	CANLF|Ensembl=ENSCAFG00000007053|UniProtKB=Q76LT7	Bcl-xL	ISS	7828536	PubMed	PTHR11256:SF12	BCL-2-LIKE PROTEIN 1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00017	DNA replication	P00527	Histones	MACMU|Ensembl=ENSMMUG00000029404|UniProtKB=F6XLZ2	Uncharacterized protein	ISS	20448842	PubMed	PTHR11426:SF173	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00006	Apoptosis signaling pathway	P00269	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00644	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IGI	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00012	Cadherin signaling pathway	P00477	GSK3beta	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=1561991|UniProtKB=A0A096MJW8	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF51	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-1
P00053	T cell activation	P01305	Calmodulin	RAT|RGD=2257|UniProtKB=P62161	Calmodulin	ISS	3885394	PubMed	PTHR23050:SF311	CALMODULIN
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MONDO|Ensembl=ENSMODG00000001775|UniProtKB=F6WJB1	Uncharacterized protein	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000025373|UniProtKB=F6ZZG9	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00034	Integrin signalling pathway	P00945	Parvin	RAT|RGD=71021|UniProtKB=Q9HB97	Alpha-parvin	ISS	11331308	PubMed	PTHR12114:SF6	ALPHA-PARVIN
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	HUMAN|HGNC=285|UniProtKB=P08588	Beta-1 adrenergic receptor	IDA	12063255	PubMed	PTHR24248:SF54	BETA-1 ADRENERGIC RECEPTOR
P00005	Angiogenesis	P00226	Delta/Serrate	MACMU|Ensembl=ENSMMUG00000018116|UniProtKB=F7FGM9	Delta-like protein	ISS	7697721	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00020	FAS signaling pathway	P00612	Fas	MOUSE|MGI=MGI=95484|UniProtKB=P25446	Tumor necrosis factor receptor superfamily member 6	TAS	1371136	PubMed	PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	CAEEL|WormBase=WBGene00002189|UniProtKB=P21137	cAMP-dependent protein kinase catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00736	CalDAG-GEF	HUMAN|HGNC=18958|UniProtKB=Q8TDF6	RAS guanyl-releasing protein 4	IDA	10835426	PubMed	PTHR23113:SF157	RAS GUANYL-RELEASING PROTEIN 4
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	PANTR|Ensembl=ENSPTRG00000034379|UniProtKB=H2RDK4	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	RCA	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00019	Endothelin signaling pathway	P00586	Gq	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MOUSE|MGI=MGI=106185|UniProtKB=P51683	C-C chemokine receptor type 2	IDA	12495638	PubMed	PTHR10489:SF913	C-C CHEMOKINE RECEPTOR TYPE 2
P00010	B cell activation	P00380	fos	MACMU|Ensembl=ENSMMUG00000010574|UniProtKB=A5A6H2	C-fos	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00019	Endothelin signaling pathway	P00591	PLCbeta	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04393	Ras Pathway	P04547	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P06664	Gonadotropin-releasing hormone receptor pathway	P06812	L-type Ca2+	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	RCA	91056091	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P02741	Flavin biosynthesis	P02940	Riboflavin synthase	CHLTR|EnsemblGenome=CT_405|UniProtKB=O84410	Riboflavin synthase	ISS			PTHR21098:SF7	RIBOFLAVIN SYNTHASE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00036	Interleukin signaling pathway	P00973	PKB	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00591	PLCbeta	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IGI	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06755	CBP	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	RCA	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04393	Ras Pathway	P04556	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	BOVIN|Ensembl=ENSBTAG00000017679|UniProtKB=F1MY55	Uncharacterized protein	ISS			PTHR24361:SF183	SERINE/THREONINE-PROTEIN KINASE PAK 7
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00054	Toll receptor signaling pathway	P01352	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00193	SOS-1	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IDA	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00059	p53 pathway	P04616	PDK1/2	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	TAS	12855688	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P02765	Phenylalanine biosynthesis	P03099	Prephenate dehydratase	METAC|EnsemblGenome=MA_3150|UniProtKB=Q8TL89	Chorismate mutase/prephenate dehydratase	ISS			PTHR21022:SF0	PREPHENATE DEHYDRATASE-RELATED
P00057	Wnt signaling pathway	P01472	Histone deacetylase	MONDO|Ensembl=ENSMODG00000017455|UniProtKB=F6Z5R3	Uncharacterized protein (Fragment)	ISS	10485845	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00020	FAS signaling pathway	P00599	Caspase3	MACMU|Ensembl=ENSMMUG00000012053|UniProtKB=F7HFY2	Uncharacterized protein	ISS	11675509	PubMed	PTHR10454:SF198	CASPASE-3
P00006	Apoptosis signaling pathway	P00269	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	8838325	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00029	Huntington disease	P00797	p53	ORNAN|Ensembl=ENSOANG00000004122|UniProtKB=F7ATP3	Uncharacterized protein	ISS			PTHR12195:SF2	CYTOPLASMIC FMR1-INTERACTING PROTEIN 1
P00005	Angiogenesis	P00203	Erk	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00718	Phosphorylase a	RAT|RGD=620687|UniProtKB=P09811	Glycogen phosphorylase, liver form	IDA	4318782	PubMed	PTHR11468:SF12	GLYCOGEN PHOSPHORYLASE, LIVER FORM
P00029	Huntington disease	P00790	beta-Tubulin	MONDO|Ensembl=ENSMODG00000003363|UniProtKB=F7CB79	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PANTR|Ensembl=ENSPTRG00000002086|UniProtKB=H2Q1A9	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00059	p53 pathway	P04633	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01160	IP3 receptor	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00021	FGF signaling pathway	P00629	PP2A	MACMU|Ensembl=ENSMMUG00000013047|UniProtKB=F7H808	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	TAS			PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00021	FGF signaling pathway	P00633	Ras	MONDO|Gene=KRAS|UniProtKB=Q07983	GTPase KRas	ISS	99084794	PubMed	PTHR24070:SF186	GTPASE KRAS
P05917	Opioid proopiomelanocortin pathway	P06007	alpha-MSH	RAT|RGD=3366|UniProtKB=P01194	Pro-opiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00005	Angiogenesis	P00215	Nck	MONDO|Ensembl=ENSMODG00000018540|UniProtKB=F7GD33	Uncharacterized protein	ISS	11689432	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	RAT|RGD=2344|UniProtKB=P08485	Muscarinic acetylcholine receptor M4	ISS	91373358	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	RAT|RGD=2959|UniProtKB=P48550	G protein-activated inward rectifier potassium channel 2	IDA	12374786	PubMed	PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=4403|UniProtKB=P61952	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	IC			PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P00048	PI3 kinase pathway	P01203	p101	PANTR|Ensembl=ENSPTRG00000008751|UniProtKB=H2QC89	Uncharacterized protein	ISS	12507995	PubMed	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P06587	Nicotine pharmacodynamics pathway	P06596	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	15210125	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00019	Endothelin signaling pathway	P00572	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00788	Calpain	CANLF|Ensembl=ENSCAFG00000010383|UniProtKB=E2R8T7	Uncharacterized protein	ISS	11675509	PubMed	PTHR10183:SF329	CALPAIN-3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=97440|UniProtKB=P35377	Nociceptin receptor	IDA	11259487	PubMed	PTHR24229:SF11	NOCICEPTIN RECEPTOR
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00037	Ionotropic glutamate receptor pathway	P01006	NR2C	MOUSE|MGI=MGI=95822|UniProtKB=Q01098	Glutamate receptor ionotropic, NMDA 2C	ISS	11554549	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00021	FGF signaling pathway	P00624	14-3-3	HUMAN|HGNC=12855|UniProtKB=P63104	14-3-3 protein zeta/delta	ISS	12615066	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00047	PDGF signaling pathway	P01174	Rho	MACMU|Ensembl=ENSMMUG00000000419|UniProtKB=F6VDT1	Uncharacterized protein	ISS	8649427	PubMed	PTHR12552:SF4	RHO GTPASE-ACTIVATING PROTEIN 26
P00005	Angiogenesis	P00256	PLC-gamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00053	T cell activation	P01315	Calcineurin	MACMU|Ensembl=ENSMMUG00000015714|UniProtKB=F6SFE0	Serine/threonine-protein phosphatase	ISS	7532676	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00020	FAS signaling pathway	P00620	CytochromeC	BRADU|EnsemblGenome=BAC47751|UniProtKB=P51131	Cytochrome b/c1	IGI	9027315	PubMed	PTHR19271:SF5	CYTOCHROME B
P00005	Angiogenesis	P00187	beta catenin	BOVIN|Ensembl=ENSBTAG00000016420|UniProtKB=Q0VCX4	Catenin beta-1	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00006	Apoptosis signaling pathway	P00272	ASK1	PANTR|Ensembl=ENSPTRG00000024326|UniProtKB=H2R231	Uncharacterized protein	ISS	12968034	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00187	beta catenin	RAT|RGD=70487|UniProtKB=Q9WU82	Catenin beta-1	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MOUSE|MGI=MGI=108520|UniProtKB=Q61088	Frizzled-4	TAS	8717036	PubMed	PTHR11309:SF23	FRIZZLED-4
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	ORYSJ|EnsemblGenome=OS03G0207300|UniProtKB=Q10Q71	Casein kinase II, alpha chain, putative, expressed	IDA	10806215	PubMed	PTHR24054:SF35	SUBFAMILY NOT NAMED
P00008	Axon guidance mediated by Slit/Robo	P00351	Cxcr4	PANTR|Ensembl=ENSPTRG00000012501|UniProtKB=P61072	C-X-C chemokine receptor type 4	ISS	11943720	PubMed	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	ENTHI|EnsemblGenome=EHI_197840|UniProtKB=C4M8K6	Rho family GTPase	ISS	97082968	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00029	Huntington disease	P00805	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00015	Circadian clock system	P00506	BMAL1	HUMAN|HGNC=701|UniProtKB=O00327	Aryl hydrocarbon receptor nuclear translocator-like protein 1	ISS	11163178	PubMed	PTHR23042:SF52	ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 1
P00001	Adrenaline and noradrenaline biosynthesis	P00066	DOPA decarb.	RAT|RGD=2494|UniProtKB=P14173	Aromatic-L-amino-acid decarboxylase	ISS	90339966	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00005	Angiogenesis	P00256	PLC-gamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04393	Ras Pathway	P04552	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00053	T cell activation	P01333	cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P02734	Chorismate biosynthesis	P02868	Chorismate synthase	ECOLI|EcoGene=EG10075|UniProtKB=P12008	Chorismate synthase	ISS			PTHR21085:SF0	CHORISMATE SYNTHASE
P00054	Toll receptor signaling pathway	P01361	TBK1	BOVIN|Ensembl=ENSBTAG00000017401|UniProtKB=E1BKP4	Uncharacterized protein	ISS			PTHR22969:SF14	SERINE/THREONINE-PROTEIN KINASE TBK1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00036	Interleukin signaling pathway	P00996	STAT	DANRE|ZFIN=ZDB-GENE-980526-499|UniProtKB=Q6P943	Signal transducer and activator of transcription	IDA	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	TAKRU|Ensembl=ENSTRUG00000008685|UniProtKB=H2TXN3	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF326	CALMODULIN
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IGI	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01143	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	8946911	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00030	Hypoxia response via HIF activation	P00817	TOR	MOUSE|MGI=MGI=1928394|UniProtKB=Q9JLN9	Serine/threonine-protein kinase mTOR	ISS	8662507	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00021	FGF signaling pathway	P00624	14-3-3	CANLF|Ensembl=ENSCAFG00000031015|UniProtKB=J9P6N4	Uncharacterized protein	ISS	6756037	gi	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00056	VEGF signaling pathway	P01422	eNOS	BOVIN|Gene=NOS3|UniProtKB=P29473	Nitric oxide synthase, endothelial	ISS	10435050	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00021	FGF signaling pathway	P00632	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	HUMAN|HGNC=143|UniProtKB=P68032	Actin, alpha cardiac muscle 1	IC	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00054	Toll receptor signaling pathway	P01357	MEKK1	MACMU|Ensembl=ENSMMUG00000012387|UniProtKB=F7EB20	Uncharacterized protein	ISS	12049732	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00017	DNA replication	P00536	DNA Topisomerase	ENTHI|EnsemblGenome=EHI_120640|UniProtKB=Q6RCM0	DNA topoisomerase 2	ISS			PTHR10169:SF38	DNA TOPOISOMERASE 2
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00048	PI3 kinase pathway	P01198	FOXO	MACMU|Ensembl=ENSMMUG00000020369|UniProtKB=F6UMX8	Uncharacterized protein	ISS	10102273	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00057	Wnt signaling pathway	P01428	Frizzled	DANRE|ZFIN=ZDB-GENE-990415-220|UniProtKB=Q9W6E3	Frizzled homolog 10	IDA	8717036	PubMed	PTHR11309:SF86	FRIZZLED-10
P05731	GABA-B receptor II signaling	P05760	AC	MOUSE|MGI=MGI=1341110|UniProtKB=P97490	Adenylate cyclase type 8	RCA	2491850	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00010	B cell activation	P00381	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00001	Adrenaline and noradrenaline biosynthesis	P00066	DOPA decarb.	MACMU|Ensembl=ENSMMUG00000019991|UniProtKB=F7FNW0	Aromatic-L-amino-acid decarboxylase	ISS	107930	OMIM	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00059	p53 pathway	P04628	14-3-3	MOUSE|MGI=MGI=1891831|UniProtKB=O70456	14-3-3 protein sigma	ISS	10407019	PubMed	PTHR18860:SF14	14-3-3 PROTEIN SIGMA
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00036	Interleukin signaling pathway	P00967	c-fos	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	TAS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00049	Parkinson disease	P01242	Casein kinase I	CHICK|Gene=CSNK1A1|UniProtKB=P67962	Casein kinase I isoform alpha	IDA	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00006	Apoptosis signaling pathway	P00312	MKK7	RAT|RGD=1560043|UniProtKB=Q4KSH7	Dual specificity mitogen-activated protein kinase kinase 7	ISS			PTHR24361:SF387	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00014	Cholesterol biosynthesis	P00494	Squalene monooxygenas	RAT|RGD=3755|UniProtKB=P52020	Squalene monooxygenase	ISS			PTHR10835:SF0	SQUALENE MONOOXYGENASE
P00010	B cell activation	P00376	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=11438|UniProtKB=Q13277	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P02748	Isoleucine biosynthesis	P02996	Ketol-acid reductoisomerase	THEMA|EnsemblGenome=TM_0550|UniProtKB=Q9WZ20	Ketol-acid reductoisomerase	ISS			PTHR21371:SF1	KETOL-ACID REDUCTOISOMERASE, CHLOROPLASTIC
P00018	EGF receptor signaling pathway	P00562	p38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IGI	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00036	Interleukin signaling pathway	P00996	STAT	CANLF|Ensembl=ENSCAFG00000015213|UniProtKB=E2RB82	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00047	PDGF signaling pathway	P01160	IP3 receptor	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	BOVIN|Ensembl=ENSBTAG00000005464|UniProtKB=E1B9K3	Uncharacterized protein	ISS	10978539	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00012	Cadherin signaling pathway	P00467	alpha-catenin	MOUSE|MGI=MGI=2661445|UniProtKB=Q65CL1	Catenin alpha-3	ISS	9362521	PubMed	PTHR18914:SF21	CATENIN ALPHA-3
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00034	Integrin signalling pathway	P00941	Integrin alpha	HUMAN|HGNC=2926|UniProtKB=Q9UGM3	Deleted in malignant brain tumors 1 protein	IPI	3487386	PubMed	PTHR19331:SF22	DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN
P05915	Opioid proenkephalin pathway	P05993	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00057	Wnt signaling pathway	P01463	Kremen	RAT|RGD=1310795|UniProtKB=D4ADS5	Kringle containing transmembrane protein 2 (Predicted)	ISS			PTHR24269:SF15	KREMEN PROTEIN 2
P00053	T cell activation	P01312	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00021	FGF signaling pathway	P00629	PP2A	BOVIN|Ensembl=ENSBTAG00000001862|UniProtKB=Q5E9Q7	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform	ISS	12110603	PubMed	PTHR11871:SF1	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B BETA ISOFORM
P00029	Huntington disease	P00807	Actin	MACMU|Ensembl=ENSMMUG00000012054|UniProtKB=F6TII3	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00005	Angiogenesis	P00199	JNKK1	MONDO|Ensembl=ENSMODG00000008266|UniProtKB=F6Z879	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00060	Ubiquitin proteasome pathway	P01491	E2	MOUSE|MGI=MGI=107412|UniProtKB=P52483	Ubiquitin-conjugating enzyme E2 E3	ISS			PTHR24068:SF63	UBIQUITIN-CONJUGATING ENZYME E2 E3
P00029	Huntington disease	P00780	Microtubule	PANTR|Ensembl=ENSPTRG00000009878|UniProtKB=H2QEA0	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00018	EGF receptor signaling pathway	G01511	SPRY	CHICK|Gene=SPRY2|UniProtKB=Q9PTL2	Protein sprouty homolog 2	IGI	99429807	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P00017	DNA replication	P00537	RPA	SCHPO|PomBase=SPCC1753.01c|UniProtKB=Q92373	Replication factor A protein 2	ISS	96355433	PubMed	PTHR13989:SF16	RPA2 PROTEIN
P00036	Interleukin signaling pathway	P00996	STAT	CANLF|Ensembl=ENSCAFG00000015213|UniProtKB=E2RB82	Signal transducer and activator of transcription	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	MOUSE|MGI=MGI=1347078|UniProtKB=O70293	G protein-coupled receptor kinase 6	IDA	8288567	PubMed	PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	IDA	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05913	Enkephalin release	P05972	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00012	Cadherin signaling pathway	P00464	Fyn	CANLF|Ensembl=ENSCAFG00000003995|UniProtKB=E2RC09	Tyrosine-protein kinase	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00034	Integrin signalling pathway	P00922	Collagen	CAEBR|Gene=CBG16372|UniProtKB=A8XNK9	Protein CBR-LET-2	ISS	10778855	PubMed	PTHR24023:SF853	COLLAGEN ALPHA-2 IV  CHAIN
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05918	p38 MAPK pathway	P06021	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	4757952	gi	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P04393	Ras Pathway	P04570	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	P01465	Ggamma	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DROME|FlyBase=FBgn0004921|UniProtKB=P38040	Guanine nucleotide-binding protein subunit gamma-1	IC			PTHR13809:SF3	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA-RELATED
P00004	Alzheimer disease-presenilin pathway	P00163	Erb-B4 C-terminal fragment	MONDO|Ensembl=ENSMODG00000015755|UniProtKB=F6ZSZ9	Uncharacterized protein (Fragment)	ISS	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MOUSE|MGI=MGI=1309999|UniProtKB=Q922R0	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IGI	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00127	APP	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01095	beta	CAEEL|WormBase=WBGene00002974|UniProtKB=Q27218	Acetylcholine receptor subunit beta-type lev-1	ISS	22213672	PubMed	PTHR18945:SF747	ACETYLCHOLINE RECEPTOR SUBUNIT BETA-TYPE LEV-1
P00054	Toll receptor signaling pathway	P01365	TAB1	HUMAN|HGNC=18157|UniProtKB=Q15750	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1	ISS	10838074	PubMed	PTHR13832:SF533	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00047	PDGF signaling pathway	P01160	IP3 receptor	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MACMU|Ensembl=ENSMMUG00000001661|UniProtKB=F7GR69	Uncharacterized protein	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00034	Integrin signalling pathway	P00951	Jnk	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000023940|UniProtKB=F6RFW8	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00542	EGFR	MOUSE|MGI=MGI=95294|UniProtKB=Q01279	Epidermal growth factor receptor	IGI	21100872	PubMed	PTHR24416:SF91	EPIDERMAL GROWTH FACTOR RECEPTOR
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	XENTR|Xenbase=XB-GENE-977853|UniProtKB=F7EBE7	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00006	Apoptosis signaling pathway	P00302	ATF	MONDO|Ensembl=ENSMODG00000006303|UniProtKB=F7BRQ2	Uncharacterized protein	ISS	11390664	PubMed	PTHR22952:SF258	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	RCA	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PRIPA|Gene=PPA19914|UniProtKB=H3FCG4	Uncharacterized protein	ISS			PTHR11937:SF359	SUBFAMILY NOT NAMED
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00017	DNA replication	P00527	Histones	STRPU|EnsemblGenome=SPU_026462|UniProtKB=W4ZE70	Uncharacterized protein	ISS	12413958	PubMed	PTHR11426:SF20	HISTONE H3-LIKE CENTROMERIC PROTEIN A
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	HUMAN|HGNC=10945|UniProtKB=O00341	Excitatory amino acid transporter 5	ISS	94365697	PubMed	PTHR11958:SF22	EXCITATORY AMINO ACID TRANSPORTER 5
P00056	VEGF signaling pathway	P01407	Erk	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	9298898	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05916	Opioid prodynorphin pathway	P05999	provasopressin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00049	Parkinson disease	P01234	GRK	DANRE|ZFIN=ZDB-GENE-030616-382|UniProtKB=B5LZ08	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF18	PROTEIN-SERINE/THREONINE KINASE
P00029	Huntington disease	P00799	JNK-2	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02922	Orotate phosphoribosyltransferase	BACSU|EnsemblGenome=BSU15560|UniProtKB=P25972	Orotate phosphoribosyltransferase	ISS			PTHR19278:SF9	URIDINE 5'-MONOPHOSPHATE SYNTHASE
P00029	Huntington disease	P00807	Actin	ORNAN|Ensembl=ENSOANG00000007405|UniProtKB=F7CIV4	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00049	Parkinson disease	P01226	CDCrel-1	MOUSE|MGI=MGI=1195461|UniProtKB=Q9Z2Q6	Septin-5	IDA	11078524	PubMed	PTHR18884:SF68	SEPTIN-5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00728	RhoGEF	PANTR|Ensembl=ENSPTRG00000011039|UniProtKB=H2QGF2	Uncharacterized protein	ISS	12123608	PubMed	PTHR12673:SF122	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 1
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-478663|UniProtKB=F7EG64	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IGI	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00059	p53 pathway	G04694	p110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00790	beta-Tubulin	XENTR|Xenbase=XB-GENE-969447|UniProtKB=Q0IIR4	Tubulin, beta 2C	ISS	9454836	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P02741	Flavin biosynthesis	P02939	Lumazine synthase	RHOBA|EnsemblGenome=RB4995|UniProtKB=Q7UGV1	6,7-dimethyl-8-ribityllumazine synthase	ISS			PTHR21058:SF0	6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE
P00057	Wnt signaling pathway	P01446	Calcineurin	MOUSE|MGI=MGI=107163|UniProtKB=P48453	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	IDA	12091710	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	CHICK|Ensembl=ENSGALG00000009621|UniProtKB=P60706	Actin, cytoplasmic 1	ISS	11889139	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MACMU|Ensembl=ENSMMUG00000000605|UniProtKB=F6Y8V8	Uncharacterized protein	ISS	12549854	PubMed	PTHR10845:SF11	AXIN-1
P00018	EGF receptor signaling pathway	P00547	PP2A	DANRE|ZFIN=ZDB-GENE-040426-2487|UniProtKB=Q803G3	Serine/threonine-protein phosphatase	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01428	Frizzled	PANTR|Ensembl=ENSPTRG00000028511|UniProtKB=H2R570	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF81	FRIZZLED-1
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000024633|UniProtKB=F1MBU9	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00021	FGF signaling pathway	P00642	MEK1-2	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=268|UniProtKB=P0DMS8	Adenosine receptor A3	IDA	11781138	PubMed	PTHR24246:SF2	ADENOSINE RECEPTOR A3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00053	T cell activation	P01336	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	HUMAN|HGNC=4588|UniProtKB=O15399	Glutamate receptor ionotropic, NMDA 2D	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2D.html	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00054	Toll receptor signaling pathway	P01379	Tollip	CHICK|Gene_ORFName=RCJMB04_14a3|UniProtKB=Q5ZK05	Toll-interacting protein	ISS			PTHR16461:SF5	TOLL-INTERACTING PROTEIN
P00053	T cell activation	P01316	MHC-antigen	HUMAN|HGNC=4942|UniProtKB=P01909	HLA class II histocompatibility antigen, DQ alpha 1 chain	IPI	73139	PubMed	PTHR19944:SF59	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DQ ALPHA 1 CHAIN
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	PANTR|Ensembl=ENSPTRG00000006342|UniProtKB=H2Q8A8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	STRPU|Gene=CYIIIA|UniProtKB=P53474	Actin, cytoskeletal 3A	IC	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IGI	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00036	Interleukin signaling pathway	P00973	PKB	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01367	MKK3	BOVIN|Ensembl=ENSBTAG00000010576|UniProtKB=A4IFH7	MAP2K3 protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MOUSE|MGI=MGI=97357|UniProtKB=P03966	N-myc proto-oncogene protein	IEP	12356903	PubMed	PTHR11514:SF3	N-MYC PROTO-ONCOGENE PROTEIN
P00049	Parkinson disease	P01227	20S proteasome	ANOGA|EnsemblGenome=AGAP010253|UniProtKB=Q7PMD7	Proteasome subunit alpha type	TAS	12859888	PubMed	PTHR11599:SF12	PROTEASOME SUBUNIT ALPHA TYPE-RELATED
P00019	Endothelin signaling pathway	P00586	Gq	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00029	Huntington disease	P00775	Rac	MACMU|Ensembl=ENSMMUG00000008203|UniProtKB=F7GWQ8	Rho-related GTP-binding protein RhoJ	ISS	12932731	PubMed	PTHR24072:SF17	RHO-RELATED GTP-BINDING PROTEIN RHOJ
P00021	FGF signaling pathway	P00628	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04546	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00004	Alzheimer disease-presenilin pathway	P00125	Ire-1 C-terminal fragment	MOUSE|MGI=MGI=1349436|UniProtKB=Q9Z2E3	Serine/threonine-protein kinase/endoribonuclease IRE2	IDA	10619423	PubMed	PTHR13954:SF15	SERINE/THREONINE-PROTEIN KINASE/ENDORIBONUCLEASE IRE2
P00029	Huntington disease	G01533	Bax	DANRE|ZFIN=ZDB-GENE-000511-6|UniProtKB=I3ITC2	Uncharacterized protein	TAS			PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00036	Interleukin signaling pathway	P00962	ELK	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	IDA	10487205	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00006	Apoptosis signaling pathway	P00276	TRAIL-R	PANTR|Ensembl=ENSPTRG00000020074|UniProtKB=H2QVW1	Tumor necrosis factor receptor superfamily, member 10a	ISS	10594023	PubMed	PTHR23097:SF179	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000018563|UniProtKB=F6YMF6	Uncharacterized protein	ISS	12441358	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	RCA	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00036	Interleukin signaling pathway	P00986	eNOS	MONDO|Ensembl=ENSMODG00000003903|UniProtKB=F6S3S1	Nitric oxide synthase	ISS	10435050	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00046	Oxidative stress response	P01125	Stat1	HUMAN|HGNC=11362|UniProtKB=P42224	Signal transducer and activator of transcription 1-alpha/beta	TAS	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00047	PDGF signaling pathway	P01173	STAT	HUMAN|HGNC=11366|UniProtKB=P42229	Signal transducer and activator of transcription 5A	ISS	95236292	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00021	FGF signaling pathway	P00642	MEK1-2	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00018	EGF receptor signaling pathway	P00558	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	3755548	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04547	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IDA	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	RCA	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00045	Notch signaling pathway	P01103	Next	RAT|RGD=3187|UniProtKB=Q07008	Neurogenic locus notch homolog protein 1	IEP	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00046	Oxidative stress response	P01129	JNK1/2	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02773	S-adenosylmethionine biosynthesis	P03142	Cobalamin-dependent homocysteine transmethylase	DEIRA|EnsemblGenome=DR_0966|UniProtKB=Q9RVQ6	5-methyltetrahydrofolate--homocysteine methyltransferase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P00059	p53 pathway	P04630	PP2A	CANLF|Ensembl=ENSCAFG00000006453|UniProtKB=F6X958	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	RCA			PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00139	E-cadherin transmembrane fragment	PANTR|Ensembl=ENSPTRG00000008269|UniProtKB=H2QBE4	Cadherin 3, type 1, P-cadherin (Placental)	ISS	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P00029	Huntington disease	P00780	Microtubule	PANTR|Ensembl=ENSPTRG00000008496|UniProtKB=H2QBS3	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P06587	Nicotine pharmacodynamics pathway	P06602	PPP1CA	BOVIN|Gene=PPP1CA|UniProtKB=Q3T0E7	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit	ISS	8392016	PubMed	PTHR11668:SF377	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-ALPHA CATALYTIC SUBUNIT
P00020	FAS signaling pathway	P00615	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	DANRE|ZFIN=ZDB-GENE-020125-3|UniProtKB=E7F1V8	Uncharacterized protein	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P02768	Proline biosynthesis	P03112	Glutamate semialdehyde dehydrogenase	METAC|EnsemblGenome=MA_4100|UniProtKB=Q9HHA1	Gamma-glutamyl phosphate reductase	ISS			PTHR11063:SF8	DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE
P00059	p53 pathway	P04633	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ARATH|TAIR=AT3G18780|UniProtKB=Q96292	Actin-2	IC	14684598	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02734	Chorismate biosynthesis	P02874	Shikimate kinase	FUSNN|EnsemblGenome=FN0822|UniProtKB=Q8RF94	Shikimate kinase	ISS			PTHR21087:SF0	SHIKIMATE KINASE 1
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05918	p38 MAPK pathway	P05922	MKP1	MOUSE|MGI=MGI=105120|UniProtKB=P28563	Dual specificity protein phosphatase 1	RCA			PTHR10159:SF309	DUAL SPECIFICITY PROTEIN PHOSPHATASE 1
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	DANRE|ZFIN=ZDB-GENE-030903-5|UniProtKB=Q6EWH2	Tyrosine-protein kinase fyna	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	MACMU|Ensembl=ENSMMUG00000014635|UniProtKB=F7G2C9	Tyrosine-protein kinase	ISS			PTHR24418:SF296	TYROSINE-PROTEIN KINASE FRK
P00012	Cadherin signaling pathway	P00467	alpha-catenin	TAKRU|Ensembl=ENSTRUG00000002863|UniProtKB=H2S2N9	Uncharacterized protein	ISS	1768802	PubMed	PTHR18914:SF29	CATENIN ALPHA-2
P00006	Apoptosis signaling pathway	P00269	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00558	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000022548|UniProtKB=F6Y9J9	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P06959	CCKR signaling map	P07103	PRKD1	HUMAN|HGNC=9407|UniProtKB=Q15139	Serine/threonine-protein kinase D1	RCA	11410586	PubMed	PTHR22968:SF9	SERINE/THREONINE-PROTEIN KINASE D1
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00228	Grb7	HUMAN|HGNC=4567|UniProtKB=Q14451	Growth factor receptor-bound protein 7	IDA	10521483	PubMed	PTHR11243:SF25	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 7
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05730	Endogenous cannabinoid signaling	P05746	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00048	PI3 kinase pathway	P01189	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	TAS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	97449291	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00052	TGF-beta signaling pathway	P01284	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02748	Isoleucine biosynthesis	P02995	Threonine dehydratase	PSEAE|EnsemblGenome=PA1326|UniProtKB=Q9I418	L-threonine dehydratase	ISS			PTHR43714:SF1	THREONINE DEHYDRATASE, MITOCHONDRIAL
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TRIAD|EnsemblGenome=TriadG63375|UniProtKB=B3S5E4	Non-muscle actin 6.2	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000004742|UniProtKB=H2Q5K1	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CAEEL|WormBase=WBGene00009595|UniProtKB=Q7JMS5	Uncharacterized protein	TAS	8413673	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00047	PDGF signaling pathway	P01159	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	CAEEL|WormBase=WBGene00002189|UniProtKB=P21137	cAMP-dependent protein kinase catalytic subunit	IC	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00045	Notch signaling pathway	P01116	Delta	MACMU|Ensembl=ENSMMUG00000019093|UniProtKB=F6TFS9	Uncharacterized protein	ISS	10742114	PubMed	PTHR24044:SF308	DELTA-LIKE PROTEIN 3
P00046	Oxidative stress response	P01129	JNK1/2	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05913	Enkephalin release	P05977	G-Protein (s)	XENTR|Xenbase=XB-GENE-956713|UniProtKB=Q5XGD8	Guanine nucleotide binding protein, beta 3	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00029	Huntington disease	P00807	Actin	CANLF|Ensembl=ENSCAFG00000012181|UniProtKB=F2Z4N7	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	HUMAN|HGNC=1608|UniProtKB=P32248	C-C chemokine receptor type 7	TAS	10941822	PubMed	PTHR10489:SF635	C-C CHEMOKINE RECEPTOR TYPE 7
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P02784	Tyrosine biosynthesis	P03214	Prephenate dehydrogenase	AQUAE|EnsemblGenome=aq_1755|UniProtKB=O67636	Prephenate dehydrogenase	ISS			PTHR21363:SF0	PREPHENATE DEHYDROGENASE  NADP +
P00020	FAS signaling pathway	P00599	Caspase3	RAT|RGD=2275|UniProtKB=P55213	Caspase-3	IGI	11675509	PubMed	PTHR10454:SF198	CASPASE-3
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=107728|UniProtKB=Q5SYD0	Unconventional myosin-Id	ISS			PTHR13140:SF417	UNCONVENTIONAL MYOSIN-ID
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	RAT|RGD=2345|UniProtKB=P04757	Neuronal acetylcholine receptor subunit alpha-3	ISS	18005395	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	RCA			PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00635	FRS2	PANTR|Ensembl=ENSPTRG00000018159|UniProtKB=H2QSZ7	Uncharacterized protein	ISS			PTHR21258:SF39	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 3
P00005	Angiogenesis	P00223	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00366	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12912997	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P02771	Pyrimidine Metabolism	P03128	Dihydrouracil Dehydrogenase	MACMU|Ensembl=ENSMMUG00000020726|UniProtKB=F7GVE2	Uncharacterized protein	ISS	8912928	PubMed	PTHR43073:SF2	DIHYDROPYRIMIDINE DEHYDROGENASE  NADP +
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	IDA	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00049	Parkinson disease	P01238	14-3-3	ORNAN|Ensembl=ENSOANG00000007305|UniProtKB=F6XW91	Uncharacterized protein	ISS	92362864	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00029	Huntington disease	P00761	Truncated Htt	MOUSE|MGI=MGI=96067|UniProtKB=P42859	Huntingtin	TAS	9462744	PubMed	PTHR10170:SF10	HUNTINGTIN
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MONDO|Ensembl=ENSMODG00000010505|UniProtKB=F7E9U1	Uncharacterized protein (Fragment)	ISS	11212302	PubMed	PTHR11309:SF81	FRIZZLED-1
P00005	Angiogenesis	P00223	Akt	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	ISS			PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00194	Paxillin	PANTR|Ensembl=ENSPTRG00000003681|UniProtKB=H2Q3Q1	Leupaxin	ISS			PTHR24216:SF23	LEUPAXIN
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MOUSE|MGI=MGI=107812|UniProtKB=P99024	Tubulin beta-5 chain	ISS	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00019	Endothelin signaling pathway	P00573	signal peptidase	MACMU|Ensembl=ENSMMUG00000004408|UniProtKB=F7GUB4	Signal peptidase complex catalytic subunit SEC11	ISS	2092035	PubMed	PTHR10806:SF12	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11C
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_206575|UniProtKB=E9FUX0	Guanine nucleotide binding protein, beta subunit	ISS	9740024	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00048	PI3 kinase pathway	P01188	Gbetagamma	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	IC	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P06587	Nicotine pharmacodynamics pathway	P06602	PPP1CA	HUMAN|HGNC=9281|UniProtKB=P62136	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit	TAS	10433257	PubMed	PTHR11668:SF377	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-ALPHA CATALYTIC SUBUNIT
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05916	Opioid prodynorphin pathway	P06000	vasopressin	PANTR|Ensembl=ENSPTRG00000013189|UniProtKB=H2QJV1	Uncharacterized protein	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P05917	Opioid proopiomelanocortin pathway	P06004	Mu or Delta receptor	MOUSE|MGI=MGI=97438|UniProtKB=P32300	Delta-type opioid receptor	RCA	12093103	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00010	B cell activation	P00376	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P04393	Ras Pathway	P04572	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02721	ATP synthesis	P02791	F1 alpha	STRCO|EnsemblGenome=CAB94542|UniProtKB=Q9K4D5	ATP synthase subunit alpha	ISS	7828915	PubMed	PTHR43089:SF2	ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL
P00057	Wnt signaling pathway	P01461	FrzB	CHICK|Ensembl=ENSGALG00000006944|UniProtKB=F1NHI6	Uncharacterized protein	IDA	10960783	PubMed	PTHR11309:SF12	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00145	CD44	PANTR|Ensembl=ENSPTRG00000003501|UniProtKB=H2Q3E8	Uncharacterized protein	ISS	12223485	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	RCA			PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CAEEL|WormBase=WBGene00000045|UniProtKB=Q9N4M3	AcetylCholine Receptor	IC			PTHR18945:SF505	ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 2
P00057	Wnt signaling pathway	P01451	Galpha	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	IDA	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P02723	Adenine and hypoxanthine salvage pathway	P02805	Adenine phosphorylase	BOVIN|Ensembl=ENSBTAG00000012317|UniProtKB=P55859	Purine nucleoside phosphorylase	ISS	9585525	PubMed	PTHR11904:SF12	PURINE NUCLEOSIDE PHOSPHORYLASE
P00019	Endothelin signaling pathway	P00570	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00912	Arp2/3	MOUSE|MGI=MGI=1343142|UniProtKB=Q9WV32	Actin-related protein 2/3 complex subunit 1B	IPI	12473693	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	TAS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	MACMU|Ensembl=ENSMMUG00000007619|UniProtKB=F7AR90	Uncharacterized protein	ISS	8407942	PubMed	PTHR20859:SF43	INTERLEUKIN-10 RECEPTOR SUBUNIT ALPHA
P00005	Angiogenesis	P00243	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	ISS	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	CAEEL|WormBase=WBGene00002202|UniProtKB=P42168	Casein kinase I isoform alpha	ISS	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	RCA	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00049	Parkinson disease	P01238	14-3-3	CHICK|Ensembl=ENSGALG00000004143|UniProtKB=Q5ZLQ6	14-3-3 protein beta/alpha	ISS	12618428	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00025	Hedgehog signaling pathway	P00691	CBP	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	HUMAN|HGNC=4586|UniProtKB=Q13224	Glutamate receptor ionotropic, NMDA 2B	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000025240|UniProtKB=F7A7I3	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P05912	Dopamine receptor mediated signaling pathway	P05952	EPB41L2	PANTR|Ensembl=ENSPTRG00000018597|UniProtKB=H2QTQ8	Erythrocyte membrane protein band 4.1-like 2	ISS	12181426	PubMed	PTHR23280:SF17	BAND 4.1-LIKE PROTEIN 2
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=16267|UniProtKB=Q9UBV4	Protein Wnt-16	IDA	11266476	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P00017	DNA replication	P00527	Histones	ORYSJ|EnsemblGenome=OS06G0160001|UniProtKB=Q2RAD9	Histone H3.2	ISS	12413958	PubMed	PTHR11426:SF172	HISTONE H3-LIKE 5-RELATED
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	CHICK|Ensembl=ENSGALG00000028612|UniProtKB=F1P3X1	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF728	MYOSIN HEAVY CHAIN, SKELETAL MUSCLE, ADULT
P00038	JAK/STAT signaling pathway	P01027	STAT	MONDO|Ensembl=ENSMODG00000014836|UniProtKB=F7D2D3	Signal transducer and activator of transcription	ISS	8732682	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00034	Integrin signalling pathway	P00920	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	ARATH|TAIR=AT4G09320|UniProtKB=P39207	Nucleoside diphosphate kinase 1	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00010	B cell activation	P00375	Calmodulin	MOUSE|MGI=MGI=103249|UniProtKB=P62204	Calmodulin	ISS	10487978	PubMed	PTHR23050:SF311	CALMODULIN
P00057	Wnt signaling pathway	P01435	SWI/SNF	MACMU|Ensembl=ENSMMUG00000017729|UniProtKB=F7F7Z2	Uncharacterized protein	ISS	11532957	PubMed	PTHR10799:SF599	E1A-BINDING PROTEIN P400
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00005	Angiogenesis	P00206	Wnt	CHICK|Gene=WNT2B|UniProtKB=Q98SN7	Protein Wnt-2b	ISS	8717036	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00021	FGF signaling pathway	P00629	PP2A	CANLF|Ensembl=ENSCAFG00000001753|UniProtKB=F1P714	Uncharacterized protein	ISS	96161994	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P02774	Salvage pyrimidine deoxyribonucleotides	P03146	Deoxyuridine kinase	DEIRA|EnsemblGenome=DR_1984|UniProtKB=Q9RSY5	Thymidine kinase	ISS			PTHR11441:SF0	THYMIDINE KINASE, CYTOSOLIC
P00056	VEGF signaling pathway	P01414	PLC-gamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00021	FGF signaling pathway	P00633	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IGI	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00005	Angiogenesis	P00203	Erk	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00015	Circadian clock system	G01501	cry	PANTR|Ensembl=ENSPTRG00000003537|UniProtKB=H2Q3H0	Uncharacterized protein	ISS	10217146	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00053	T cell activation	P01324	rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P05918	p38 MAPK pathway	P06029	p38beta	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	RCA	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P02738	De novo purine biosynthesis	P02909	GDP reductase	ECOLI|EcoGene=EG10661|UniProtKB=P69924	Ribonucleoside-diphosphate reductase 1 subunit beta	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02748	Isoleucine biosynthesis	P02997	Acetolactate synthase	ECOLI|EcoGene=EG10494|UniProtKB=P08142	Acetolactate synthase isozyme 1 large subunit	ISS			PTHR18968:SF128	ACETOLACTATE SYNTHASE ISOZYME 1 LARGE SUBUNIT
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00010	B cell activation	P00376	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00030	Hypoxia response via HIF activation	P00814	P300	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04375	5HT3 type receptor mediated signaling pathway	P04425	K+ channel	HUMAN|HGNC=6278|UniProtKB=O14649	Potassium channel subfamily K member 3	ISS	11875121	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00056	VEGF signaling pathway	P01408	Akt/PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01181	GSK3	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00865	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	8264585	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IC	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	IGI	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00206	Wnt	MACMU|Ensembl=ENSMMUG00000001325|UniProtKB=F7BGU5	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	ORNAN|Ensembl=ENSOANG00000002061|UniProtKB=F7ANC6	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00045	Notch signaling pathway	G01541	E(spl)-C genes	BOVIN|Ensembl=ENSBTAG00000015717|UniProtKB=Q2KIN4	Hairy/enhancer-of-split related with YRPW motif protein 1	ISS			PTHR10985:SF78	HAIRY/ENHANCER-OF-SPLIT RELATED WITH YRPW MOTIF PROTEIN 1
P00052	TGF-beta signaling pathway	P01275	P38	CAEEL|WormBase=WBGene00004056|UniProtKB=Q8MXI4	Mitogen-activated protein kinase pmk-2	TAS	10514528	PubMed	PTHR24055:SF154	MITOGEN-ACTIVATED PROTEIN KINASE PMK-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000022513|UniProtKB=F6YNZ0	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=2136756|UniProtKB=Q91Y02	Protocadherin beta-18	IDA	8120095	PubMed	PTHR24028:SF54	PROTOCADHERIN BETA-10
P00038	JAK/STAT signaling pathway	P01027	STAT	HUMAN|HGNC=11368|UniProtKB=P42226	Signal transducer and activator of transcription 6	ISS	94367369	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IGI	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT3G59790|UniProtKB=Q9M1Z5	Mitogen-activated protein kinase 10	IDA			PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	PANTR|Ensembl=ENSPTRG00000001617|UniProtKB=H2Q0I5	Aldehyde dehydrogenase 9 family, member A1	ISS			PTHR11699:SF228	4-TRIMETHYLAMINOBUTYRALDEHYDE DEHYDROGENASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	PANTR|Ensembl=ENSPTRG00000008766|UniProtKB=H2QC97	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF504	MYOSIN-13
P04393	Ras Pathway	P04574	PLD	ORYSJ|EnsemblGenome=OS01G0172400|UniProtKB=Q43007	Phospholipase D alpha 1	ISS			PTHR18896:SF11	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00062	TH	PANTR|Ensembl=ENSPTRG00000003173|UniProtKB=H2Q2W7	Uncharacterized protein	ISS	12480184	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06830	AMPK	MOUSE|MGI=MGI=2145955|UniProtKB=Q5EG47	5'-AMP-activated protein kinase catalytic subunit alpha-1	RCA			PTHR24343:SF306	5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1
P00007	Axon guidance mediated by semaphorins	P00329	Sema4D	MOUSE|MGI=MGI=109244|UniProtKB=O09126	Semaphorin-4D	ISS			PTHR11036:SF18	SEMAPHORIN-4D
P00053	T cell activation	P01331	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00019	Endothelin signaling pathway	P00577	PI3K	DROME|FlyBase=FBgn0015278|UniProtKB=Q7K3H0	LD28067p	IGI	7937853	PubMed	PTHR10048:SF64	LD28067P
P05915	Opioid proenkephalin pathway	P05994	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	BOVIN|Ensembl=ENSBTAG00000020079|UniProtKB=F1N3T0	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=24667|UniProtKB=Q8TD08	Mitogen-activated protein kinase 15	ISS	10514528	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00020	FAS signaling pathway	P00600	PARP	ORYSJ|Gene=Os01g0351200|UniProtKB=Q5Z8Q9	Poly [ADP-ribose] polymerase 2-A	TAS	12101391	PubMed	PTHR10459:SF96	SUBFAMILY NOT NAMED
P00049	Parkinson disease	P01230	Src kinase	MACMU|Ensembl=ENSMMUG00000014149|UniProtKB=F7BV42	Tyrosine-protein kinase	ISS	1371009	PubMed	PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P00005	Angiogenesis	P00243	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00018	EGF receptor signaling pathway	P00551	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	DROME|FlyBase=FBgn0001105|UniProtKB=P26308	Guanine nucleotide-binding protein subunit beta-1	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00006	Apoptosis signaling pathway	P00260	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P06002	G-protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	ISS	11535291	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P02740	De novo pyrimidine ribonucleotides biosythesis	P02926	Aspartate carbamoyltransferase	SYNY3|EnsemblGenome=BAA18252|UniProtKB=P74163	Aspartate carbamoyltransferase	ISS			PTHR11405:SF16	ASPARTATE CARBAMOYLTRANSFERASE, CHLOROPLASTIC
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00021	FGF signaling pathway	P00628	JNK1-3	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00036	Interleukin signaling pathway	P00996	STAT	BOVIN|Gene=STAT3|UniProtKB=P61635	Signal transducer and activator of transcription 3	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	HUMAN|HGNC=711|UniProtKB=P49407	Beta-arrestin-1	IDA	11742073	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	MOUSE|MGI=MGI=88276|UniProtKB=Q02248	Catenin beta-1	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P00011	Blood coagulation	P00454	FVII	HUMAN|HGNC=3544|UniProtKB=P08709	Coagulation factor VII	ISS	10518503	gi	PTHR44064:SF1	COAGULATION FACTOR VII
P00036	Interleukin signaling pathway	P00965	ERK	RAT|RGD=62087|UniProtKB=P27704	Mitogen-activated protein kinase 6	ISS	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	BOVIN|Ensembl=ENSBTAG00000021672|UniProtKB=F1MUR0	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF34	REGULATOR OF G-PROTEIN SIGNALING 1
P00020	FAS signaling pathway	P00594	Caspase8	MOUSE|MGI=MGI=1261423|UniProtKB=O89110	Caspase-8	IGI	8681376	PubMed	PTHR10454:SF162	CASPASE-8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEEL|WormBase=WBGene00004033|UniProtKB=P90980	Protein kinase C-like 2	IC	15572354	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00018	EGF receptor signaling pathway	P00564	Rac	MONDO|Ensembl=ENSMODG00000003244|UniProtKB=F6THF0	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	14744428	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00630	RKIP	ANOGA|EnsemblGenome=AGAP008909|UniProtKB=Q7PWN1	AGAP008909-PA	ISS			PTHR11362:SF28	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P00022	General transcription by RNA polymerase I	P00651	TAF-IA	DANRE|ZFIN=ZDB-GENE-040426-1013|UniProtKB=Q6P0T2	Transcription initiation factor TFIID subunit 8	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00034	Integrin signalling pathway	P00927	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CANLF|Ensembl=ENSCAFG00000016020|UniProtKB=O18840	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00037	Ionotropic glutamate receptor pathway	P01001	KA4	CHICK|Ensembl=ENSGALG00000006638|UniProtKB=R4GGL9	Uncharacterized protein	ISS	1648176	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05913	Enkephalin release	G06046	preproenkephalin mRNA	DANRE|ZFIN=ZDB-GENE-030729-31|UniProtKB=A8E7S2	Uncharacterized protein	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P02725	Allantoin degradation	P02818	Ureidoglycolate hydrolase	SCHPO|PomBase=SPAC19G12.04|UniProtKB=O13843	Ureidoglycolate lyase	ISS			PTHR21221:SF1	UREIDOGLYCOLATE LYASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00977	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P06664	Gonadotropin-releasing hormone receptor pathway	P06757	JUN	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	RCA	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00051	TCA cycle	P01269	alphaketoglutarate Dehydrogenase	MOUSE|MGI=MGI=1098267|UniProtKB=Q60597	2-oxoglutarate dehydrogenase, mitochondrial	ISS	12477932	PubMed	PTHR23152:SF7	2-OXOGLUTARATE DEHYDROGENASE, MITOCHONDRIAL
P00059	p53 pathway	P04616	PDK1/2	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	TAS	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	RAT|RGD=61862|UniProtKB=P19491	Glutamate receptor 2	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	PANTR|Ensembl=ENSPTRG00000002979|UniProtKB=H2Q2M8	Uncharacterized protein	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	MOUSE|MGI=MGI=1931148|UniProtKB=Q9WV84	Nucleoside diphosphate kinase, mitochondrial	ISS			PTHR11349:SF49	NUCLEOSIDE DIPHOSPHATE KINASE, MITOCHONDRIAL
P00024	Glycolysis	P00674	Phosphoglucose isomerase	MACMU|Ensembl=ENSMMUG00000005880|UniProtKB=F6TLQ6	Glucose-6-phosphate isomerase	RCA			PTHR11469:SF4	GLUCOSE-6-PHOSPHATE ISOMERASE
P00005	Angiogenesis	P00211	GSK3beta	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	BOVIN|Ensembl=ENSBTAG00000003512|UniProtKB=E1BPX8	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF358	MYOSIN-7B
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000004742|UniProtKB=H2Q5K1	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P02777	Succinate to proprionate conversion	P03163	Methylmalonyl-CoA decarboxylase	PANTR|Ensembl=ENSPTRG00000018580|UniProtKB=H2QTQ0	Uncharacterized protein	RCA			PTHR11941:SF27	ETHYLMALONYL-COA DECARBOXYLASE
P00049	Parkinson disease	P01211	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01306	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00012	Cadherin signaling pathway	P00467	alpha-catenin	CHICK|Ensembl=ENSGALG00000002447|UniProtKB=E1C7M7	Uncharacterized protein	ISS	10456847	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MOUSE|MGI=MGI=108460|UniProtKB=Q61091	Frizzled-8	TAS	11212302	PubMed	PTHR11309:SF90	FRIZZLED-8
P00047	PDGF signaling pathway	P01167	Ets	CANLF|Ensembl=ENSCAFG00000031552|UniProtKB=J9NXI6	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF31	ETS DOMAIN-CONTAINING TRANSCRIPTION FACTOR ERF
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	MACMU|Ensembl=ENSMMUG00000000983|UniProtKB=F6SYL4	Fructose-bisphosphate aldolase	ISS	74094688	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00021	FGF signaling pathway	P00644	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P02755	Methylmalonyl pathway	P03034	Methylmalonyl-CoA mutase	STRCO|Gene=CAB92663|UniProtKB=Q9KY64	Isobutiryl CoA mutase, small subunit	ISS			PTHR23408:SF19	SUBFAMILY NOT NAMED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02785	Valine biosynthesis	P03215	Branched chain amino acid aminotransferase	METJA|EnsemblGenome=MJ_1008|UniProtKB=Q58414	Putative branched-chain-amino-acid aminotransferase	ISS			PTHR42743:SF3	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE-LIKE PROTEIN 1-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	DANRE|ZFIN=ZDB-GENE-030616-53|UniProtKB=Q71E60	AMPA receptor subunit GluR3B	ISS	20112749	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P05912	Dopamine receptor mediated signaling pathway	P05962	DAT	HUMAN|HGNC=11049|UniProtKB=Q01959	Sodium-dependent dopamine transporter	ISS	15135042	PubMed	PTHR11616:SF38	SODIUM-DEPENDENT DOPAMINE TRANSPORTER
P00034	Integrin signalling pathway	P00944	Actin	MONDO|Ensembl=ENSMODG00000023940|UniProtKB=F6RFW8	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	DANRE|ZFIN=ZDB-GENE-030131-2299|UniProtKB=F1R966	Clathrin heavy chain	ISS	9388255	PubMed	PTHR10292:SF1	CLATHRIN HEAVY CHAIN
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00053	T cell activation	P01320	PLC-gamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00036	Interleukin signaling pathway	P00990	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02786	Vitamin B6 biosynthesis	P03225	1-Deoxyxylulose-5-phosphate synthase	AQUAE|EnsemblGenome=aq_881|UniProtKB=O67036	1-deoxy-D-xylulose-5-phosphate synthase	ISS			PTHR43322:SF6	1-DEOXY-D-XYLULOSE-5-PHOSPHATE SYNTHASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	TAKRU|Ensembl=ENSTRUG00000011944|UniProtKB=H2TZX5	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00020	FAS signaling pathway	P00611	Gelsolin	BOVIN|Gene=SCIN|UniProtKB=Q28046	Adseverin	IGI	9323209	PubMed	PTHR11977:SF78	ADSEVERIN
P05730	Endogenous cannabinoid signaling	P05751	Galpha	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P02770	Pyridoxal phosphate salvage pathway	P03120	Pyridoxamine-5-phosphate oxidase	PANTR|Ensembl=ENSPTRG00000009343|UniProtKB=H2QDB2	Pyridoxamine 5'-phosphate oxidase	ISS	14697241	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00057	Wnt signaling pathway	P01456	beta-arrestin	MACMU|Ensembl=ENSMMUG00000023359|UniProtKB=F7E8B5	Uncharacterized protein	ISS	10206946	PubMed	PTHR11792:SF15	S-ARRESTIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00636	FGFR1-4	CHICK|Gene=FGFR2|UniProtKB=P18461	Fibroblast growth factor receptor 2	ISS	1373495	PubMed	PTHR24416:SF130	FIBROBLAST GROWTH FACTOR RECEPTOR 2
P00059	p53 pathway	G01568	KILLER/DR5	PANTR|Ensembl=ENSPTRG00000020074|UniProtKB=H2QVW1	Tumor necrosis factor receptor superfamily, member 10a	ISS	10594023	PubMed	PTHR23097:SF179	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10A
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	USTMA|Gene=UMAG_11232|UniProtKB=A0A0D1DMT3	Chromosome 22, whole genome shotgun sequence	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000019361|UniProtKB=H2QUV3	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00059	p53 pathway	P04609	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	DROME|FlyBase=FBgn0002413|UniProtKB=O76324	Discs overgrown protein kinase	IDA	11955435	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00057	Wnt signaling pathway	P01465	Ggamma	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00047	PDGF signaling pathway	P01160	IP3 receptor	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	RAT|RGD=1305848|UniProtKB=P85970	Actin-related protein 2/3 complex subunit 2	ISS	12473693	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00021	FGF signaling pathway	P00633	Ras	DICPU|Gene=DICPUDRAFT_92731|UniProtKB=F0ZWE6	Putative uncharacterized protein rasG	ISS	7997267	PubMed	PTHR24070:SF282	RAS GTPASE-RELATED
P00006	Apoptosis signaling pathway	P00318	PKCs	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	IDA	3045562	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00010	B cell activation	P00402	Jnk	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	12855688	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IGI	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00590	IP3 R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00056	VEGF signaling pathway	P01407	Erk	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00060	Ubiquitin proteasome pathway	P01491	E2	TAKRU|Ensembl=ENSTRUG00000016580|UniProtKB=H2UZL2	Uncharacterized protein	ISS			PTHR43902:SF2	UBIQUITIN-CONJUGATING ENZYME E2 N
P00034	Integrin signalling pathway	P00916	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IPI	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MONDO|Ensembl=ENSMODG00000001933|UniProtKB=F6W0P2	Uncharacterized protein (Fragment)	ISS	12488551	PubMed	PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	SCHPO|PomBase=SPBC8D2.01|UniProtKB=Q9URT9	Protein kinase gsk31	ISS	11995474	gi	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P02788	Xanthine and guanine salvage pathway	P03248	Deoxyguanosine phosphorylase	MOUSE|MGI=MGI=3712328|UniProtKB=Q9D8C9	Purine nucleoside phosphorylase	ISS	7903568	PubMed	PTHR11904:SF12	PURINE NUCLEOSIDE PHOSPHORYLASE
P00017	DNA replication	P00533	Pol delta	RAT|RGD=1304954|UniProtKB=Q6AXY4	DNA polymerase delta subunit 2	ISS	12522211	PubMed	PTHR10416:SF0	DNA POLYMERASE DELTA SUBUNIT 2
P00029	Huntington disease	P00805	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02749	Leucine biosynthesis	P03000	Branched chain amino acid aminotransferase	HUMAN|HGNC=976|UniProtKB=P54687	Branched-chain-amino-acid aminotransferase, cytosolic	ISS			PTHR11825:SF51	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, CYTOSOLIC
P00057	Wnt signaling pathway	P01444	Wnt	XENTR|Xenbase=XB-GENE-493706|UniProtKB=Q28IC7	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P00049	Parkinson disease	P01236	Casein kinase II	MOUSE|MGI=MGI=88548|UniProtKB=P67871	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04393	Ras Pathway	P04552	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00048	PI3 kinase pathway	P01192	p110	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00552	Ras	DROME|FlyBase=FBgn0003206|UniProtKB=P04388	Ras-like protein 2	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00037	Ionotropic glutamate receptor pathway	P01015	Glu4	HUMAN|HGNC=4574|UniProtKB=P48058	Glutamate receptor 4	ISS	12871085	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00021	FGF signaling pathway	P00628	JNK1-3	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00231	HSP27	MONDO|Ensembl=ENSMODG00000014453|UniProtKB=F7ATA8	Uncharacterized protein	ISS			PTHR11527:SF37	ALPHA-CRYSTALLIN B CHAIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	RAT|RGD=2929|UniProtKB=G3V7M2	Integrin beta	ISS	12391210	PubMed	PTHR10082:SF36	INTEGRIN BETA-7
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00005	Angiogenesis	P00182	p38MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00010	B cell activation	P00379	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	CHICK|Ensembl=ENSGALG00000003806|UniProtKB=O93467	GTP-binding protein	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347740|UniProtKB=E9FXV8	Cytoplasmatic actin	ISS	10974003	PubMed	PTHR11937:SF277	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	IDA	11035810	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00021	FGF signaling pathway	P00645	Rac	DICPU|Gene=DICPUDRAFT_55703|UniProtKB=F0ZN94	Putative uncharacterized protein racC	ISS	94124042	PubMed	PTHR24072:SF117	RHO-RELATED PROTEIN RACC
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IGI	12707323	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00005	Angiogenesis	P00244	MAPKAPK2/3	BOVIN|Ensembl=ENSBTAG00000016532|UniProtKB=Q3SYZ2	MAP kinase-activated protein kinase 3	ISS	11335727	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00548	RKIP	DROME|FlyBase=FBgn0038973|UniProtKB=Q9VD01	LP12095p	ISS			PTHR11362:SF28	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00021	FGF signaling pathway	P00633	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00059	p53 pathway	P01486	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	12655147	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05972	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00011	Blood coagulation	P00458	GP IIIa	MACMU|Ensembl=ENSMMUG00000003289|UniProtKB=F7FG54	Integrin beta	ISS	3487386	PubMed	PTHR10082:SF25	INTEGRIN BETA-3
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_188187|UniProtKB=E9GJ31	Guanine nucleotide binding protein, q polypeptide	ISS	8457205	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00034	Integrin signalling pathway	P00941	Integrin alpha	PANTR|Ensembl=ENSPTRG00000002321|UniProtKB=H2Q1N7	Uncharacterized protein	ISS	10778855	PubMed	PTHR23220:SF5	INTEGRIN ALPHA-8
P00005	Angiogenesis	P00223	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	XENTR|Xenbase=XB-GENE-489222|UniProtKB=Q28GJ8	Ras homolog gene family, member A	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00053	T cell activation	P01309	fos	CANLF|Ensembl=ENSCAFG00000017040|UniProtKB=E2QYK5	Uncharacterized protein	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00019	Endothelin signaling pathway	P00566	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01143	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	97442349	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00646	RasGAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	14707121	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	MONDO|Ensembl=ENSMODG00000000771|UniProtKB=F6SSS3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00034	Integrin signalling pathway	P00933	Crk	HUMAN|HGNC=2363|UniProtKB=P46109	Crk-like protein	IPI	8649368	PubMed	PTHR19969:SF9	CRK-LIKE PROTEIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00053	T cell activation	P01324	rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12912997	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00095	Nicastrin	DROME|FlyBase=FBgn0039234|UniProtKB=Q9VC27	Nicastrin	IDA	10993067	PubMed	PTHR21092:SF0	NICASTRIN
P00021	FGF signaling pathway	P00629	PP2A	MONDO|Ensembl=ENSMODG00000014177|UniProtKB=F6U7A6	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04398	p53 pathway feedback loops 2	P04660	SIAH-1	RAT|RGD=620449|UniProtKB=Q920M9	E3 ubiquitin-protein ligase SIAH1	ISS	14985507	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00019	Endothelin signaling pathway	P00583	cPLA2	MONDO|Ensembl=ENSMODG00000011791|UniProtKB=F7CBU9	Phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00021	FGF signaling pathway	P00626	Spry	PANTR|Ensembl=ENSPTRG00000005951|UniProtKB=H2Q7P2	Sprouty homolog 2	ISS	12815057	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CAEBR|Gene=CBG05858|UniProtKB=A8X1H0	Protein CBR-EGL-19 (Fragment)	ISS	10514528	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00273	p53	CANLF|Gene=TP53|UniProtKB=Q29537	Cellular tumor antigen p53	ISS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P06664	Gonadotropin-releasing hormone receptor pathway	P06768	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	RCA	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00048	PI3 kinase pathway	P01179	PKB	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	TAS	12089061	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00034	Integrin signalling pathway	P00927	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00922	Collagen	HUMAN|HGNC=2194|UniProtKB=Q9UMD9	Collagen alpha-1(XVII) chain	IDA	10778855	PubMed	PTHR44606:SF1	COLLAGEN ALPHA-1 XVII  CHAIN
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P02766	Phenylethylamine degradation	P03103	Phenylethylamine oxidase	SCHPO|PomBase=SPAC2E1P3.04|UniProtKB=Q9P7F2	Copper amine oxidase 1	ISS			PTHR10638:SF41	AMINE OXIDASE
P00057	Wnt signaling pathway	P01451	Galpha	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	IDA	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00049	Parkinson disease	P01230	Src kinase	HUMAN|HGNC=3955|UniProtKB=P42685	Tyrosine-protein kinase FRK	IDA	11162638	PubMed	PTHR24418:SF296	TYROSINE-PROTEIN KINASE FRK
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01160	IP3 receptor	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00114	actin	SCHMA|EnsemblGenome=Smp_046600|UniProtKB=G4VLW2	Putative actin-1	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00021	FGF signaling pathway	P00641	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00243	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00797	p53	HUMAN|HGNC=11998|UniProtKB=P04637	Cellular tumor antigen p53	TAS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00006	Apoptosis signaling pathway	P00273	p53	PANTR|Ensembl=ENSPTRG00000008703|UniProtKB=H2QC53	Cellular tumor antigen p53	ISS	11313951	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00053	T cell activation	P01300	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04553	PAK	MONDO|Ensembl=ENSMODG00000005255|UniProtKB=F7G800	Uncharacterized protein	ISS	7559398	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05726	2-arachidonoylglycerol biosynthesis	P05735	PLA1	HUMAN|HGNC=17661|UniProtKB=Q53H76	Phospholipase A1 member A	IC			PTHR11610:SF111	PHOSPHOLIPASE A1 MEMBER A
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00049	Parkinson disease	P01230	Src kinase	TAKRU|Ensembl=ENSTRUG00000003538|UniProtKB=H2S7D1	Tyrosine-protein kinase	ISS	11162638	PubMed	PTHR24418:SF242	TYROSINE-PROTEIN KINASE FYNB
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Ensembl=ENSBTAG00000011579|UniProtKB=F1N5C5	Muscarinic acetylcholine receptor	ISS			PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05913	Enkephalin release	P05974	G-Protein (i)	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00053	T cell activation	P01332	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00996	STAT	TAKRU|Ensembl=ENSTRUG00000015348|UniProtKB=H2UQK9	Signal transducer and activator of transcription	ISS	11879641	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05918	p38 MAPK pathway	P06029	p38beta	BOVIN|Ensembl=ENSBTAG00000030182|UniProtKB=G3X793	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00053	T cell activation	P01336	Jnk	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=1565392|UniProtKB=A0A0G2K8I5	Protein Pcdh19	ISS	8120095	PubMed	PTHR24028:SF40	PROTOCADHERIN-19
P00059	p53 pathway	P01486	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	TAS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00010	B cell activation	P00376	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	87226391	PubMed	PTHR24070:SF385	GTPASE HRAS
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MACMU|Ensembl=ENSMMUG00000009287|UniProtKB=F7H3T9	Glutamate receptor 1 isoform 1	ISS	12941441	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	MOUSE|MGI=MGI=87994|UniProtKB=P05064	Fructose-bisphosphate aldolase A	ISS	3391172	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	USTMA|Gene=UMAG_02508|UniProtKB=A0A0D1DZV9	Chromosome 6, whole genome shotgun sequence	IC			PTHR11699:SF211	ALDEHYDE DEHYDROGENASE 5, MITOCHONDRIAL
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00545	JNK1-3	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS			PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF31	SUBFAMILY NOT NAMED
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-9966|UniProtKB=Q6TH03	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00029	Huntington disease	P00790	beta-Tubulin	SCHMA|EnsemblGenome=Smp_079960|UniProtKB=G4VTA4	Putative tubulin beta chain	ISS	9454836	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	ORNAN|Ensembl=ENSOANG00000002406|UniProtKB=F7BAS2	Uncharacterized protein	ISS	7559398	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00016	Cytoskeletal regulation by Rho GTPase	P00510	mDia	MACMU|Ensembl=ENSMMUG00000020862|UniProtKB=F7HNC0	Uncharacterized protein	ISS			PTHR23213:SF174	PROTEIN DIAPHANOUS HOMOLOG 2
P00012	Cadherin signaling pathway	P00465	TCF/LEF	BOVIN|Ensembl=ENSBTAG00000006844|UniProtKB=E1BJ93	Uncharacterized protein	ISS	9039917	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00001	Adrenaline and noradrenaline biosynthesis	P00071	VAT1	RAT|RGD=3693|UniProtKB=Q01818	Chromaffin granule amine transporter	ISS	12135927	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00059	p53 pathway	P01482	ARF	MOUSE|MGI=MGI=105387|UniProtKB=Q60773	Cyclin-dependent kinase 4 inhibitor D	ISS			PTHR24148:SF47	CYCLIN-DEPENDENT KINASE 4 INHIBITOR B-RELATED
P00018	EGF receptor signaling pathway	P00561	STAT	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00034	Integrin signalling pathway	P00924	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P06664	Gonadotropin-releasing hormone receptor pathway	P06737	p300	MOUSE|MGI=MGI=1276116|UniProtKB=B2RWS6	Histone acetyltransferase p300	RCA	10769018	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PANTR|Ensembl=ENSPTRG00000018890|UniProtKB=Q5R1X3	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00048	PI3 kinase pathway	P01182	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00018	EGF receptor signaling pathway	P00558	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	HUMAN|HGNC=11537|UniProtKB=O00268	Transcription initiation factor TFIID subunit 4	ISS	10973244	PubMed	PTHR15138:SF18	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4
P00011	Blood coagulation	P00440	ATIII	BOVIN|Gene=SERPINC1|UniProtKB=P41361	Antithrombin-III	ISS	1168462	gi	PTHR11461:SF53	ANTITHROMBIN-III
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00046	Oxidative stress response	P01125	Stat1	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	TAS	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00048	PI3 kinase pathway	P01192	p110	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	7937853	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00010	B cell activation	P00402	Jnk	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IDA	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00034	Integrin signalling pathway	P00932	FAK	BOVIN|Ensembl=ENSBTAG00000009578|UniProtKB=G3N3B7	Uncharacterized protein	ISS	12640026	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00059	p53 pathway	G04693	WIP-1	RAT|RGD=1305460|UniProtKB=B1WCA0	Ppm1d protein	ISS			PTHR13832:SF359	PROTEIN PHOSPHATASE 1D
P00009	Axon guidance mediated by netrin	P00366	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00005	Angiogenesis	P00223	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00007	Axon guidance mediated by semaphorins	P00338	Neuropilin 1	CHICK|Gene=NRP1|UniProtKB=P79795	Neuropilin-1	ISS			PTHR44185:SF1	NEUROPILIN-1
P00053	T cell activation	P01311	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	METAC|EnsemblGenome=MA_1665|UniProtKB=Q8TQ86	Ribonucleotide reductase	ISS			PTHR43371:SF1	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00029	Huntington disease	P00774	Dynein complex	MONDO|Ensembl=ENSMODG00000013290|UniProtKB=F6ZK75	Uncharacterized protein (Fragment)	ISS	9454836	PubMed	PTHR10676:SF314	CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	ISS	12001934	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	STRPU|EnsemblGenome=SPU_026078|UniProtKB=W4ZD41	Uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF277	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	BOVIN|Ensembl=ENSBTAG00000002295|UniProtKB=F1N177	Uncharacterized protein	ISS	9819389	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00005	Angiogenesis	P00236	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	ISS			PTHR10048:SF14	PI-3 KINASE
P04397	p53 pathway by glucose deprivation	P04640	p53	CHICK|Ensembl=ENSGALG00000007324|UniProtKB=F1N8Z7	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00005	Angiogenesis	P00226	Delta/Serrate	MACMU|Ensembl=ENSMMUG00000001276|UniProtKB=F7BUF3	Delta-like protein	ISS			PTHR44097:SF1	PROTEIN JAGGED-2
P00049	Parkinson disease	P01228	DAT	HUMAN|HGNC=11049|UniProtKB=Q01959	Sodium-dependent dopamine transporter	ISS	92107910	PubMed	PTHR11616:SF38	SODIUM-DEPENDENT DOPAMINE TRANSPORTER
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	TAKRU|Ensembl=ENSTRUG00000006464|UniProtKB=H2STT5	Uncharacterized protein	ISS	8576107	PubMed	PTHR24070:SF382	RAS-RELATED PROTEIN RAP-1B
P00048	PI3 kinase pathway	P01192	p110	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000005792|UniProtKB=F6VTR8	Uncharacterized protein	ISS	129387	gi	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000014334|UniProtKB=F7CYY6	Uncharacterized protein	ISS	11248120	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P06959	CCKR signaling map	P07214	RAC1-GTP	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	RCA	15331357	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00519	ROCK	BOVIN|Gene=ROCK2|UniProtKB=Q28021	Rho-associated protein kinase 2	ISS			PTHR22988:SF28	RHO-ASSOCIATED PROTEIN KINASE 2
P00036	Interleukin signaling pathway	P00972	MNK1/2	HUMAN|HGNC=7110|UniProtKB=Q9BUB5	MAP kinase-interacting serine/threonine-protein kinase 1	TAS	9155018	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P02787	Vitamin B6 metabolism	P03236	Pyridoxamine phosphate oxidase	HUMAN|HGNC=30260|UniProtKB=Q9NVS9	Pyridoxine-5'-phosphate oxidase	ISS	14697241	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00034	Integrin signalling pathway	P00944	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g210933|UniProtKB=A7SEA7	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	MACMU|Ensembl=ENSMMUG00000020819|UniProtKB=F7HSM1	Serine/threonine-protein phosphatase	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00071	VAT1	MOUSE|MGI=MGI=106684|UniProtKB=Q8R090	Chromaffin granule amine transporter	ISS	12135927	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00018	EGF receptor signaling pathway	P00542	EGFR	MACMU|Gene=EGFR|UniProtKB=P55245	Epidermal growth factor receptor	ISS	20540545	gi	PTHR24416:SF91	EPIDERMAL GROWTH FACTOR RECEPTOR
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04547	Ras	MONDO|Gene=KRAS|UniProtKB=Q07983	GTPase KRas	ISS	3023884	PubMed	PTHR24070:SF186	GTPASE KRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000017482|UniProtKB=H2QRX4	Uncharacterized protein	ISS			PTHR24248:SF17	ALPHA-1B ADRENERGIC RECEPTOR
P00029	Huntington disease	G01535	PIG3	MOUSE|MGI=MGI=88527|UniProtKB=P47199	Quinone oxidoreductase	ISS	12932731	PubMed	PTHR44154:SF1	QUINONE OXIDOREDUCTASE
P00047	PDGF signaling pathway	P01171	PLCgamma	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00019	Endothelin signaling pathway	P00570	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	IDA	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00184	Src	BOVIN|Ensembl=ENSBTAG00000008938|UniProtKB=E1BIM8	Tyrosine-protein kinase	ISS	8054685	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	ANOGA|EnsemblGenome=AGAP006521|UniProtKB=Q7Q5C3	AGAP006521-PA	ISS			PTHR10218:SF229	GUANINE NUCLEOTIDE-BINDING PROTEIN G F  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02769	Purine metabolism	P03118	Guanine Deaminase	NEUCR|Gene=NCU09621|UniProtKB=Q1K8M4	Guanine deaminase	ISS			PTHR11271:SF38	SUBFAMILY NOT NAMED
P05734	Synaptic vesicle trafficking	P05779	Synaptobrevin	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	RCA	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	RCA	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	RCA	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	MACMU|Ensembl=ENSMMUG00000003145|UniProtKB=F7EPF6	Uncharacterized protein	ISS			PTHR11767:SF52	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 4
P05916	Opioid prodynorphin pathway	P06000	vasopressin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00059	p53 pathway	P04633	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=11332|UniProtKB=P32745	Somatostatin receptor type 3	IDA	12441358	PubMed	PTHR24229:SF42	SOMATOSTATIN RECEPTOR TYPE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00034	Integrin signalling pathway	P00925	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00056	VEGF signaling pathway	P01407	Erk	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05913	Enkephalin release	P05972	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	RAT|RGD=2500|UniProtKB=Q920D2	Dihydrofolate reductase	ISS			PTHR22778:SF16	DIHYDROFOLATE REDUCTASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TRIVA|Gene=TVAG_054030|UniProtKB=A2G1K5	Actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	ORNAN|Ensembl=ENSOANG00000000818|UniProtKB=F6PLI7	Uncharacterized protein	ISS	11431030	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00011	Blood coagulation	P00436	GP 1bbeta	HUMAN|HGNC=4440|UniProtKB=P13224	Platelet glycoprotein Ib beta chain	ISS	97403789	PubMed	PTHR22650:SF7	PLATELET GLYCOPROTEIN IB BETA CHAIN
P00029	Huntington disease	P00775	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00034	Integrin signalling pathway	P00909	ASAP1	HUMAN|HGNC=15852|UniProtKB=Q8N6T3	ADP-ribosylation factor GTPase-activating protein 1	IPI			PTHR23180:SF35	ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00006	Apoptosis signaling pathway	P00288	TNFR1	MOUSE|MGI=MGI=1314884|UniProtKB=P25118	Tumor necrosis factor receptor superfamily member 1A	ISS			PTHR23097:SF177	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1A
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	ORNAN|Ensembl=ENSOANG00000000460|UniProtKB=F7F4W9	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	CAEBR|Gene=CBG12631|UniProtKB=A8XG73	Protein CBR-RAB-10	ISS			PTHR24073:SF316	IP08727P-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	RAT|RGD=735101|UniProtKB=Q6P9T8	Tubulin beta-4B chain	ISS	9454836	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P05918	p38 MAPK pathway	P06020	p38delta	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	RCA	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P02734	Chorismate biosynthesis	P02868	Chorismate synthase	THEMA|EnsemblGenome=TM_0347|UniProtKB=Q9WYI2	Chorismate synthase	ISS			PTHR21085:SF0	CHORISMATE SYNTHASE
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	MACMU|Ensembl=ENSMMUG00000002943|UniProtKB=F7GZY5	Glutaminyl-tRNA synthetase	ISS			PTHR43097:SF1	GLUTAMINE--TRNA LIGASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000024992|UniProtKB=F6TUR3	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	BACSU|EnsemblGenome=BSU39860|UniProtKB=P46329	Probable aldehyde dehydrogenase AldX	IC			PTHR43570:SF16	ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Ensembl=ENSPTRG00000017441|UniProtKB=H2QRU7	Glutamate receptor, ionotropic, AMPA 1	ISS	12941441	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Gene=CHRM2|UniProtKB=Q9N2A7	Muscarinic acetylcholine receptor M2 (Fragment)	ISS	8100450	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00021	FGF signaling pathway	P00639	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	7680960	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00018	EGF receptor signaling pathway	P00557	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00045	Notch signaling pathway	P01110	Presenilin	DANRE|ZFIN=ZDB-GENE-991119-4|UniProtKB=Q9W6T7	Presenilin-1	IGI	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00019	Endothelin signaling pathway	P00566	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00047	PDGF signaling pathway	P01161	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ANOGA|EnsemblGenome=AGAP005912|UniProtKB=Q7Q6D3	AGAP005912-PA	IC	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00577	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IGI	10799299	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00054	Toll receptor signaling pathway	P01375	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00182	p38MAPK	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	ISS	10995439	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00059	p53 pathway	P01486	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00211	GSK3beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00006	Apoptosis signaling pathway	P00310	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02738	De novo purine biosynthesis	P02889	dGDP kinase	MOUSE|MGI=MGI=97355|UniProtKB=P15532	Nucleoside diphosphate kinase A	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	IDA	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00053	T cell activation	P01336	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00006	Apoptosis signaling pathway	P00263	TRAIL	MACMU|Ensembl=ENSMMUG00000019302|UniProtKB=F6WNP8	Uncharacterized protein	ISS	12421926	PubMed	PTHR11471:SF27	TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00010	B cell activation	P00386	Calcineurin	RAT|RGD=3382|UniProtKB=P63329	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	IDA	12091710	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00046	Oxidative stress response	P01131	MKP5	MOUSE|MGI=MGI=105120|UniProtKB=P28563	Dual specificity protein phosphatase 1	TAS			PTHR10159:SF309	DUAL SPECIFICITY PROTEIN PHOSPHATASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	PANTR|Ensembl=ENSPTRG00000008770|UniProtKB=H2QC99	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF385	MYOSIN-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00034	Integrin signalling pathway	P00927	Rac	DICDI|dictyBase=DDB_G0279605|UniProtKB=P34148	Rho-related protein racB	IGI	4757952	gi	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00011	Blood coagulation	P00461	PAR-4	HUMAN|HGNC=3540|UniProtKB=Q96RI0	Proteinase-activated receptor 4	ISS	4503639	gi	PTHR24232:SF22	PROTEINASE-ACTIVATED RECEPTOR 4
P00020	FAS signaling pathway	P00604	Pro-Caspase8	MACMU|Ensembl=ENSMMUG00000031296|UniProtKB=F7C587	Uncharacterized protein	ISS	11917123	PubMed	PTHR10454:SF162	CASPASE-8
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	ARATH|TAIR=AT4G09320|UniProtKB=P39207	Nucleoside diphosphate kinase 1	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01456	beta-arrestin	PANTR|Ensembl=ENSPTRG00000008601|UniProtKB=H2QBY1	Arrestin, beta 2	ISS	11742073	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P06959	CCKR signaling map	P07175	RHEB-GDP	HUMAN|HGNC=10011|UniProtKB=Q15382	GTP-binding protein Rheb	RCA	19339977	PubMed	PTHR24070:SF264	GTP-BINDING PROTEIN RHEB
P00053	T cell activation	P01330	IKK	BOVIN|Ensembl=ENSBTAG00000007599|UniProtKB=Q95KV0	Inhibitor of nuclear factor kappa-B kinase subunit beta	IGI	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00021	FGF signaling pathway	P00632	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	IGI	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04662	cyclin G	MONDO|Ensembl=ENSMODG00000007651|UniProtKB=F7FZG0	Uncharacterized protein	ISS	11983168	PubMed	PTHR10177:SF59	CYCLIN-G1
P00038	JAK/STAT signaling pathway	P01034	Jak	DANRE|ZFIN=ZDB-GENE-980526-142|UniProtKB=O12990	Tyrosine-protein kinase JAK1	ISS	11929133	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00234	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P02740	De novo pyrimidine ribonucleotides biosythesis	P02922	Orotate phosphoribosyltransferase	YEAST|SGD=S000004884|UniProtKB=P30402	Orotate phosphoribosyltransferase 2	ISS			PTHR19278:SF9	URIDINE 5'-MONOPHOSPHATE SYNTHASE
P00034	Integrin signalling pathway	P00937	Vinculin	PANTR|Ensembl=ENSPTRG00000002647|UniProtKB=H2Q246	Uncharacterized protein	ISS	14702644	PubMed	PTHR18914:SF1	VINCULIN
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00012	Cadherin signaling pathway	P00475	Frizzled	MACMU|Ensembl=ENSMMUG00000007486|UniProtKB=F6QL95	Frizzled-3	ISS	11212302	PubMed	PTHR11309:SF22	FRIZZLED-3
P05913	Enkephalin release	P05976	Enkephalin	MOUSE|MGI=MGI=104629|UniProtKB=P22005	Proenkephalin-A	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00049	Parkinson disease	P01212	p38 MAPK	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	NAS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01433	SIAH-1	HUMAN|HGNC=10857|UniProtKB=Q8IUQ4	E3 ubiquitin-protein ligase SIAH1	ISS	14985507	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00021	FGF signaling pathway	P00627	ERK1-2	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IGI	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00577	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00030	Hypoxia response via HIF activation	P00824	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00060	Ubiquitin proteasome pathway	P01490	E3	CHICK|Ensembl=ENSGALG00000004655|UniProtKB=F1NFN4	Uncharacterized protein	ISS	11252892	PubMed	PTHR11254:SF293	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	MOUSE|MGI=MGI=97453|UniProtKB=P35454	Oxytocin-neurophysin 1	ISS	192340	OMIM	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00036	Interleukin signaling pathway	P00990	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00005	Angiogenesis	P00206	Wnt	CANLF|Ensembl=ENSCAFG00000032632|UniProtKB=J9P2Q5	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00057	Wnt signaling pathway	P01453	Ebi	ARATH|TAIR=AT5G67320|UniProtKB=Q9FN19	AT5g67320/K8K14_4	ISS	11389839	PubMed	PTHR22846:SF2	F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN TBL1X
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	XENTR|Xenbase=XB-GENE-854877|UniProtKB=F7C949	Presenilin	ISS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00639	Shc	MOUSE|MGI=MGI=98296|UniProtKB=P98083	SHC-transforming protein 1	IGI	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00009	Axon guidance mediated by netrin	P00366	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00034	Integrin signalling pathway	P00925	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00570	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04374	5HT2 type receptor mediated signaling pathway	P04413	K+ channel	MONDO|Ensembl=ENSMODG00000015769|UniProtKB=F6ZSC2	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P04393	Ras Pathway	P04542	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IDA	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00060	Ubiquitin proteasome pathway	P01494	19S proteasome	ANOGA|EnsemblGenome=AGAP003008|UniProtKB=Q7PGR3	AGAP003008-PA	ISS			PTHR23073:SF8	26S PROTEASE REGULATORY SUBUNIT 6B
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000020224|UniProtKB=H2Q9G3	Mitogen-activated protein kinase 6	ISS	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00006	Apoptosis signaling pathway	P00269	MAPK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	MACMU|Ensembl=ENSMMUG00000000288|UniProtKB=P61275	C-C motif chemokine 2	ISS			PTHR12015:SF98	C-C MOTIF CHEMOKINE 2
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	MOUSE|MGI=MGI=1340024|UniProtKB=Q8R0Y6	Cytosolic 10-formyltetrahydrofolate dehydrogenase	IC			PTHR11699:SF120	CYTOSOLIC 10-FORMYLTETRAHYDROFOLATE DEHYDROGENASE
P00029	Huntington disease	P00766	Htt	CANLF|Ensembl=ENSCAFG00000014682|UniProtKB=F1P7Y7	Uncharacterized protein	ISS	9462744	PubMed	PTHR10170:SF10	HUNTINGTIN
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05730	Endogenous cannabinoid signaling	P05751	Galpha	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00053	T cell activation	P01318	PKC-theta	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IGI	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00053	T cell activation	P01332	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	HUMAN|HGNC=1388|UniProtKB=O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	14624853	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MACMU|Ensembl=ENSMMUG00000011466|UniProtKB=F7B2R8	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MACMU|Ensembl=ENSMMUG00000021600|UniProtKB=F7E4H6	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF137	BONE MORPHOGENETIC PROTEIN 6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DANRE|ZFIN=ZDB-GENE-030131-1229|UniProtKB=Q6DHS1	Actin, alpha 2, smooth muscle, aorta	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00018	EGF receptor signaling pathway	P00545	JNK1-3	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IGI	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=2136750|UniProtKB=Q91Y04	Protein Pcdhb15	IDA	8120095	PubMed	PTHR24028:SF69	PROTOCADHERIN BETA-7
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00718	Phosphorylase a	RAT|RGD=3460|UniProtKB=P53534	Glycogen phosphorylase, brain form (Fragment)	IDA	4318782	PubMed	PTHR11468:SF1	GLYCOGEN PHOSPHORYLASE, BRAIN FORM
P00005	Angiogenesis	P00226	Delta/Serrate	CANLF|Ensembl=ENSCAFG00000005627|UniProtKB=E2QUR0	Delta-like protein	ISS	8955070	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	MOUSE|MGI=MGI=1931148|UniProtKB=Q9WV84	Nucleoside diphosphate kinase, mitochondrial	ISS			PTHR11349:SF49	NUCLEOSIDE DIPHOSPHATE KINASE, MITOCHONDRIAL
P00020	FAS signaling pathway	P00617	FasL	MOUSE|MGI=MGI=99255|UniProtKB=P41047	Tumor necrosis factor ligand superfamily member 6	ISS	12787569	PubMed	PTHR11471:SF33	TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 6
P00020	FAS signaling pathway	P00601	c-Jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00049	Parkinson disease	P01238	14-3-3	CANLF|Ensembl=ENSCAFG00000031015|UniProtKB=J9P6N4	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_115566|UniProtKB=C3XYC8	Putative uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P02762	Pentose phosphate pathway	P03070	Gluconate Dehydrogenase	CANLF|Ensembl=ENSCAFG00000016797|UniProtKB=F1PE09	6-phosphogluconate dehydrogenase, decarboxylating	ISS	8978909	PubMed	PTHR11811:SF25	6-PHOSPHOGLUCONATE DEHYDROGENASE, DECARBOXYLATING
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IDA	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00021	FGF signaling pathway	P00633	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00018	EGF receptor signaling pathway	P00565	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	IGI	87218499	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05915	Opioid proenkephalin pathway	P05987	peptide F	HUMAN|HGNC=8831|UniProtKB=P01210	Proenkephalin-A	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DROME|FlyBase=FBgn0030011|UniProtKB=Q9W3J1	Gbeta5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g239788|UniProtKB=A7RPI8	Predicted protein	ISS			PTHR23050:SF245	AT16150P-RELATED
P04393	Ras Pathway	P04557	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	SYNY3|EnsemblGenome=BAA18299|UniProtKB=P74208	CTP synthase	ISS			PTHR11550:SF0	CTP SYNTHASE
P00048	PI3 kinase pathway	P01179	PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00047	PDGF signaling pathway	P01145	c-fos	MACMU|Ensembl=ENSMMUG00000010574|UniProtKB=A5A6H2	C-fos	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	MONDO|Ensembl=ENSMODG00000005927|UniProtKB=F6WX28	Uncharacterized protein	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00021	FGF signaling pathway	P00629	PP2A	DANRE|ZFIN=ZDB-GENE-030904-7|UniProtKB=Q8AXX6	Ppp2r5e2 protein	ISS	10092233	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IGI	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MONDO|Ensembl=ENSMODG00000014313|UniProtKB=F7BTW0	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00020	FAS signaling pathway	P00601	c-Jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	8837781	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	CHICK|Ensembl=ENSGALG00000011699|UniProtKB=F1NEC3	Uncharacterized protein	IC	21222856	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CHICK|Gene=WNT8C|UniProtKB=P51030	Protein Wnt-8c	TAS	11266476	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P00057	Wnt signaling pathway	P01465	Ggamma	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P02752	Mannose metabolism	P03015	GDP-Mannose 4,6-dehydratase	CHICK|Ensembl=ENSGALG00000012843|UniProtKB=F1P299	Uncharacterized protein	ISS	9603974	PubMed	PTHR43715:SF1	GDP-MANNOSE 4,6 DEHYDRATASE
P00034	Integrin signalling pathway	P00923	Arf1	HUMAN|HGNC=652|UniProtKB=P84077	ADP-ribosylation factor 1	IPI	12932731	PubMed	PTHR11711:SF234	ADP-RIBOSYLATION FACTOR 1
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00005	Angiogenesis	P00193	SOS-1	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00010	B cell activation	P00369	MEKK	MOUSE|MGI=MGI=1346874|UniProtKB=Q61084	Mitogen-activated protein kinase kinase kinase 3	IDA	9006902	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00170	Aph-1	CAEEL|WormBase=WBGene00000147|UniProtKB=O45876	Gamma-secretase subunit aph-1	IDA	12471034	PubMed	PTHR12889:SF0	GAMMA-SECRETASE SUBUNIT APH-1
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P06211	BMP/activin signaling pathway-drosophila	P06254	Co-Smad	DROME|FlyBase=FBgn0011655|UniProtKB=O62609	Mothers against decapentaplegic homolog	RCA	http://flybase.org/reports/FBgn0011655.html	Website	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P00018	EGF receptor signaling pathway	P00551	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IGI	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04632	SIRT-1	PANTR|Ensembl=ENSPTRG00000002548|UniProtKB=H2Q1Z0	Uncharacterized protein	ISS	12006491	PubMed	PTHR11085:SF15	NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1
P00010	B cell activation	P00384	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	ISS	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	IGI	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00029	Huntington disease	P00807	Actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	IDA	3487386	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00054	Toll receptor signaling pathway	P01352	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00053	T cell activation	P01307	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	6264430	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00059	p53 pathway	P04634	Cdc2	MOUSE|MGI=MGI=88351|UniProtKB=P11440	Cyclin-dependent kinase 1	ISS			PTHR24056:SF334	CYCLIN-DEPENDENT KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00859	NFkappaB	MACMU|Ensembl=ENSMMUG00000007418|UniProtKB=F6QZH6	Uncharacterized protein	RCA			PTHR24169:SF1	TRANSCRIPTION FACTOR P65
P00059	p53 pathway	P01486	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00624	14-3-3	HUMAN|HGNC=12855|UniProtKB=P63104	14-3-3 protein zeta/delta	ISS	92283271	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=262|UniProtKB=P30542	Adenosine receptor A1	ISS	11781138	PubMed	PTHR24246:SF1	ADENOSINE RECEPTOR A1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g229095|UniProtKB=A7S027	Predicted protein	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P06587	Nicotine pharmacodynamics pathway	P06614	TH	MOUSE|MGI=MGI=98735|UniProtKB=P24529	Tyrosine 3-monooxygenase	RCA	191290	OMIM	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PHYPA|Gene=PHYPADRAFT_225906|UniProtKB=A9TVP1	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00047	PDGF signaling pathway	P01143	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00796	Kainate receptor	PANTR|Ensembl=ENSPTRG00000013825|UniProtKB=H2RAK4	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P02767	Phenylpropionate degradation	P03106	4-Hydroxy-2-ketovalerate aldolase	MYCTU|EnsemblGenome=LH57_18930|UniProtKB=O06334	4-hyroxy-2-oxovalerate aldolase	ISS			PTHR10277:SF3	4-HYDROXY-2-OXOVALERATE ALDOLASE
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	PANTR|Ensembl=ENSPTRG00000002178|UniProtKB=H2Q1F7	Adenylosuccinate synthetase isozyme 2	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00057	Wnt signaling pathway	P01438	PP2A	MOUSE|MGI=MGI=1321159|UniProtKB=P63330	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00633	Ras	CAEEL|WormBase=WBGene00002335|UniProtKB=P22981	Ras protein let-60	IGI	12024031	PubMed	PTHR24070:SF385	GTPASE HRAS
P05731	GABA-B receptor II signaling	P05755	Gbeta	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	HUMAN|HGNC=10013|UniProtKB=Q15835	Rhodopsin kinase	IDA	8260489	PubMed	PTHR24355:SF11	RHODOPSIN KINASE
P00021	FGF signaling pathway	P00629	PP2A	CHICK|Ensembl=ENSGALG00000010273|UniProtKB=P48463	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	1662645	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00233	CSL	CANLF|Ensembl=ENSCAFG00000016387|UniProtKB=E2QV83	Uncharacterized protein	ISS	8406481	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00010	B cell activation	P00375	Calmodulin	ANOGA|EnsemblGenome=AGAP010957|UniProtKB=Q7QGY7	AGAP010957-PA (Fragment)	ISS	7514101	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00021	FGF signaling pathway	P00641	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05918	p38 MAPK pathway	P06023	MEF	PANTR|Ensembl=ENSPTRG00000001460|UniProtKB=H2R268	Myocyte enhancer factor 2D	ISS			PTHR11945:SF23	MYOCYTE-SPECIFIC ENHANCER FACTOR 2D
P00023	General transcription regulation	P00659	TFIIEbeta	SCHPO|PomBase=SPCC1672.08c|UniProtKB=P79011	Transcription initiation factor IIE subunit beta	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00645	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12676940	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	CANLF|Ensembl=ENSCAFG00000004930|UniProtKB=E2RFB5	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04393	Ras Pathway	P04557	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	ANOGA|EnsemblGenome=AGAP009558|UniProtKB=Q7QG89	AGAP009558-PA	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	HUMAN|HGNC=2460|UniProtKB=P67870	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	BOVIN|Ensembl=ENSBTAG00000005464|UniProtKB=E1B9K3	Uncharacterized protein	ISS	93028552	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00029	Huntington disease	P00810	GAPDH	YEAST|SGD=S000003769|UniProtKB=P00358	Glyceraldehyde-3-phosphate dehydrogenase 2	IPI			PTHR10836:SF52	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED
P00021	FGF signaling pathway	P00644	p38	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	8925912	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00018	EGF receptor signaling pathway	P00562	p38	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	8925912	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	ISS	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00045	Notch signaling pathway	P01112	CoR	CANLF|Ensembl=ENSCAFG00000006985|UniProtKB=F1PQQ7	Uncharacterized protein	ISS	11112321	PubMed	PTHR13992:SF21	NUCLEAR RECEPTOR COREPRESSOR 2
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	STRCO|Gene=CAB89023|UniProtKB=Q9KZC7	Putative glutamine synthetase	ISS			PTHR43785:SF2	TYPE-1 GLUTAMINE SYNTHETASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00543	ERK1-2	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	IGI	13430383	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00025	Hedgehog signaling pathway	P00692	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	ANOGA|EnsemblGenome=AGAP006521|UniProtKB=Q7Q5C3	AGAP006521-PA	ISS			PTHR10218:SF229	GUANINE NUCLEOTIDE-BINDING PROTEIN G F  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00928	alpha actinin	BOVIN|Gene=ACTN2|UniProtKB=Q3ZC55	Alpha-actinin-2	ISS	2116421	PubMed	PTHR43947:SF4	ALPHA-ACTININ-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CAEBR|Gene=CBG02161|UniProtKB=A8WS32	Protein CBG02161	ISS	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05917	Opioid proopiomelanocortin pathway	P06011	AC	BOVIN|Ensembl=ENSBTAG00000019210|UniProtKB=F1MJV4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010034|UniProtKB=F1PEE8	Uncharacterized protein	ISS	15226293	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00046	Oxidative stress response	P01135	p38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=24667|UniProtKB=Q8TD08	Mitogen-activated protein kinase 15	ISS	12787066	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P02740	De novo pyrimidine ribonucleotides biosythesis	P02928	Dihydroorotase	PSEAE|EnsemblGenome=PA5541|UniProtKB=Q9HT33	Dihydroorotase	ISS			PTHR43668:SF2	ALLANTOINASE
P00053	T cell activation	P01311	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IDA	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00648	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	IGI	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00059	p53 pathway	P04623	CBP	ARATH|TAIR=AT1G16710|UniProtKB=Q9FWQ5	Histone acetyltransferase HAC12	ISS	10664585	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	2837282	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8682|UniProtKB=Q9Y5F2	Protocadherin beta-11	IDA	8120095	PubMed	PTHR24028:SF91	PROTOCADHERIN BETA-11
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=3765|UniProtKB=P30938	Somatostatin receptor type 5	IDA	12181435	PubMed	PTHR24229:SF20	SOMATOSTATIN RECEPTOR TYPE 5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00056	VEGF signaling pathway	P01411	Ras	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00053	T cell activation	P01300	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00015	Circadian clock system	G01499	per	BOVIN|Ensembl=ENSBTAG00000003889|UniProtKB=F1MDK3	Uncharacterized protein	ISS	20570170	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	PANTR|Ensembl=ENSPTRG00000009085|UniProtKB=H2RDQ2	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00048	PI3 kinase pathway	P01199	Galpha	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00005	Angiogenesis	P00238	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	P01432	Beta-Catenin	PANTR|Ensembl=ENSPTRG00000023062|UniProtKB=H2R2U1	Catenin (Cadherin-associated protein), beta 1, 88kDa	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00049	Parkinson disease	P01230	Src kinase	PANTR|Ensembl=ENSPTRG00000018511|UniProtKB=H2QTK7	Tyrosine-protein kinase	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P02785	Valine biosynthesis	P03216	Acetolactate synthase	SULSO|EnsemblGenome=SSO1012|UniProtKB=Q97ZB3	Acetolactate synthase large subunit homolog (IlvB-3)	ISS			PTHR42981:SF2	PYRUVATE DEHYDROGENASE  UBIQUINONE
P00050	Plasminogen activating cascade	P01243	uPA	RAT|RGD=3343|UniProtKB=P29598	Urokinase-type plasminogen activator	ISS			PTHR24264:SF38	UROKINASE-TYPE PLASMINOGEN ACTIVATOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DICDI|dictyBase=DDB_G0289489|UniProtKB=P07828	Actin-18	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00507	Rho	MOUSE|MGI=MGI=106028|UniProtKB=Q62159	Rho-related GTP-binding protein RhoC	ISS	14871999	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05731	GABA-B receptor II signaling	P05752	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00556	PLCgamma	DROME|FlyBase=FBgn0003416|UniProtKB=Q9VXH3	Phosphoinositide phospholipase C	IGI			PTHR10336:SF91	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00005	Angiogenesis	P00243	Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-8225|UniProtKB=Q7SZZ5	Uncharacterized protein	ISS			PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DANRE|ZFIN=ZDB-GENE-000322-1|UniProtKB=Q9I8V1	Actin, alpha 1, skeletal muscle	ISS	10974003	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00029	Huntington disease	P00807	Actin	STRPU|EnsemblGenome=SPU_012282|UniProtKB=W4Y969	Uncharacterized protein	IDA	10974003	PubMed	PTHR11937:SF369	ACTIN-42A
P00029	Huntington disease	P00780	Microtubule	HUMAN|HGNC=16257|UniProtKB=Q9H4B7	Tubulin beta-1 chain	IDA	12932731	PubMed	PTHR11588:SF112	TUBULIN BETA-1 CHAIN
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	HUMAN|HGNC=4581|UniProtKB=Q13003	Glutamate receptor ionotropic, kainate 3	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00006	Apoptosis signaling pathway	P00302	ATF	RAT|RGD=1303317|UniProtKB=Q4G097	Atf6b protein	ISS	11390664	PubMed	PTHR22952:SF168	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-6 BETA
P00012	Cadherin signaling pathway	P00470	F-actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g210933|UniProtKB=A7SEA7	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05916	Opioid prodynorphin pathway	P06002	G-protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	1499560	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	22533439	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P02750	Lipoate_biosynthesis	P03003	Lipoyl-protein ligase	ANOGA|EnsemblGenome=AGAP000530|UniProtKB=Q5TV84	AGAP000530-PA	ISS			PTHR13620:SF36	WERNER SYNDROME-LIKE EXONUCLEASE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	ISS	14744463	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01411	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	MOUSE|MGI=MGI=88494|UniProtKB=Q01147	Cyclic AMP-responsive element-binding protein 1	RCA			PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00009	Axon guidance mediated by netrin	P00357	Netrin	BOVIN|Ensembl=ENSBTAG00000003183|UniProtKB=A7MB18	NTN4 protein	ISS	2538453	PubMed	PTHR10574:SF282	NETRIN-4
P00056	VEGF signaling pathway	P01420	FAK	CANLF|Ensembl=ENSCAFG00000001217|UniProtKB=E2RGP8	Uncharacterized protein (Fragment)	ISS	9182576	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00048	PI3 kinase pathway	P01199	Galpha	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	IC	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00005	Angiogenesis	P00218	STAT1	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02759	Pyridoxal-5-phosphate biosynthesis	P03058	Phosphohydroxythreonine aminotransferase	ARATH|TAIR=AT4G35630|UniProtKB=Q96255	Phosphoserine aminotransferase 1, chloroplastic	ISS	15237069	gi	PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	RCA	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02778	Sulfate assimilation	P03165	Sulfite reductase	DICDI|dictyBase=DDB_G0293904|UniProtKB=Q54B10	NADPH oxidoreductase A	ISS			PTHR19384:SF89	SULFITE REDUCTASE  NADPH  FLAVOPROTEIN COMPONENT
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	CANLF|Ensembl=ENSCAFG00000015905|UniProtKB=E2QUH6	Uncharacterized protein	ISS	9388255	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	HUMAN|HGNC=145|UniProtKB=P63267	Actin, gamma-enteric smooth muscle	IDA	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P05918	p38 MAPK pathway	P06044	GADD45	HUMAN|HGNC=4095|UniProtKB=P24522	Growth arrest and DNA damage-inducible protein GADD45 alpha	IDA	10097101	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P00057	Wnt signaling pathway	P01444	Wnt	CAEBR|Gene=CBG06978|UniProtKB=A8X402	Protein CBR-CWN-1	ISS	8717036	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00010	B cell activation	P00398	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IGI	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00056	VEGF signaling pathway	P01406	VEGF	DANRE|ZFIN=ZDB-GENE-990415-273|UniProtKB=O73682	Vascular endothelial growth factor A-A	ISS			PTHR12025:SF14	VASCULAR ENDOTHELIAL GROWTH FACTOR A-A
P00021	FGF signaling pathway	P00632	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05918	p38 MAPK pathway	P05922	MKP1	PANTR|Ensembl=ENSPTRG00000017534|UniProtKB=H2QS06	Dual specificity protein phosphatase	ISS			PTHR10159:SF309	DUAL SPECIFICITY PROTEIN PHOSPHATASE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	ANOGA|EnsemblGenome=AGAP010278|UniProtKB=Q7Q0L5	AGAP010278-PA	ISS			PTHR22778:SF16	DIHYDROFOLATE REDUCTASE
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00034	Integrin signalling pathway	P00931	Integrin beta	MACMU|Ensembl=ENSMMUG00000000951|UniProtKB=F6QYS6	Integrin beta	ISS	3487386	PubMed	PTHR10082:SF15	INTEGRIN BETA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P02748	Isoleucine biosynthesis	P02994	Branched chain amino acid aminotransferase	MACMU|Ensembl=ENSMMUG00000012223|UniProtKB=F6VFZ3	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF51	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, CYTOSOLIC
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00021	FGF signaling pathway	P00630	RKIP	MOUSE|MGI=MGI=1920773|UniProtKB=Q9D9G2	Phosphatidylethanolamine-binding protein 4	ISS			PTHR11362:SF70	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	STRPU|EnsemblGenome=SPU_018419|UniProtKB=W4YRI6	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00010	B cell activation	P00381	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01457	GBeta	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IDA	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05730	Endogenous cannabinoid signaling	P05748	mGluR	RAT|RGD=2742|UniProtKB=P23385	Metabotropic glutamate receptor 1	ISS	9407094	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000037429|UniProtKB=F1MGM3	Uncharacterized protein	ISS	12441358	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P02734	Chorismate biosynthesis	P02871	2-Deoxy-7-phosphoheptulonate synthase	NEUCR|EnsemblGenome=EFNCRG00000009555|UniProtKB=Q7SCQ0	Phospho-2-dehydro-3-deoxyheptonate aldolase	ISS			PTHR21225:SF0	PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, TYROSINE-INHIBITED
P00009	Axon guidance mediated by netrin	P00366	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	10540223	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00048	PI3 kinase pathway	P01185	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00165	E-cadherin N-terminal fragment	XENTR|Xenbase=XB-GENE-482277|UniProtKB=F6QAX3	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	DROME|FlyBase=FBgn0260964|UniProtKB=Q8IH57	GH10249p	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ARATH|TAIR=AT1G09100|UniProtKB=O04019	26S protease regulatory subunit 6A homolog B	ISS			PTHR23073:SF7	26S PROTEASE REGULATORY SUBUNIT 6A
P00057	Wnt signaling pathway	P01472	Histone deacetylase	RAT|RGD=1562895|UniProtKB=B1WC68	Histone deacetylase 8	ISS	10485845	PubMed	PTHR10625:SF142	HISTONE DEACETYLASE 8
P00018	EGF receptor signaling pathway	P00565	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	22533439	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IC	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00047	PDGF signaling pathway	P01167	Ets	MOUSE|MGI=MGI=1916507|UniProtKB=Q9JHC9	ETS-related transcription factor Elf-2	ISS	15298723	PubMed	PTHR11849:SF10	ETS-RELATED TRANSCRIPTION FACTOR ELF-2
P00021	FGF signaling pathway	P00646	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	IPI	20908895	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MONDO|Gene=KRAS|UniProtKB=Q07983	GTPase KRas	ISS	3023884	PubMed	PTHR24070:SF186	GTPASE KRAS
P05734	Synaptic vesicle trafficking	P05773	Munc13	HUMAN|HGNC=23147|UniProtKB=Q70J99	Protein unc-13 homolog D	TAS	608897	OMIM	PTHR10774:SF98	PROTEIN UNC-13 HOMOLOG D
P00048	PI3 kinase pathway	P01182	Ras	DICPU|Gene=DICPUDRAFT_91367|UniProtKB=F0ZB76	Putative uncharacterized protein rasD	ISS	85024887	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	MOUSE|MGI=MGI=96433|UniProtKB=Q60751	Insulin-like growth factor 1 receptor	ISS	6754360	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00050	Plasminogen activating cascade	P01251	MMP-3	MACMU|Ensembl=ENSMMUG00000004249|UniProtKB=F6YVN6	Uncharacterized protein	ISS	3477804	PubMed	PTHR10201:SF215	STROMELYSIN-1
P00005	Angiogenesis	P00222	VEGFR-2	CANLF|Ensembl=ENSCAFG00000002079|UniProtKB=Q2XPT7	Uncharacterized protein	ISS	11221852	PubMed	PTHR24416:SF45	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	XENTR|Xenbase=XB-GENE-961282|UniProtKB=Q6DF43	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04398	p53 pathway feedback loops 2	P04665	AKT	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00023	General transcription regulation	P00660	RNA Polymerase II	ARATH|TAIR=AT5G57980|UniProtKB=Q9FJL8	DNA-directed RNA polymerase subunit 5-like protein 1	ISS	11313498	PubMed	PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P00005	Angiogenesis	P00243	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00018	EGF receptor signaling pathway	P00560	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00059	p53 pathway	P04609	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	14526383	PubMed	PTHR10048:SF14	PI-3 KINASE
P00034	Integrin signalling pathway	P00925	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IDA	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02738	De novo purine biosynthesis	P02908	Phosphoribosylamine glycine ligase	CHICK|Gene=GART|UniProtKB=P21872	Trifunctional purine biosynthetic protein adenosine-3	ISS			PTHR10520:SF10	TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MACMU|Ensembl=ENSMMUG00000021442|UniProtKB=F7EAQ8	Muscarinic acetylcholine receptor	ISS	12181435	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TRIAD|EnsemblGenome=TriadG56111|UniProtKB=B3RX77	Non-muscle actin 6.2	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00045	Notch signaling pathway	P01116	Delta	DANRE|ZFIN=ZDB-GENE-990415-47|UniProtKB=Q8UWJ4	Delta-like protein D	TAS	12361969	PubMed	PTHR24044:SF380	DELTA-LIKE PROTEIN 1
P02771	Pyrimidine Metabolism	P03128	Dihydrouracil Dehydrogenase	HUMAN|HGNC=3012|UniProtKB=Q12882	Dihydropyrimidine dehydrogenase [NADP(+)]	IDA	1512248	PubMed	PTHR43073:SF2	DIHYDROPYRIMIDINE DEHYDROGENASE  NADP +
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MOUSE|MGI=MGI=87902|UniProtKB=P68134	Actin, alpha skeletal muscle	ISS	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00010	B cell activation	P00384	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04393	Ras Pathway	P04557	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	IDA	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00642	MEK1-2	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P06664	Gonadotropin-releasing hormone receptor pathway	P06728	Caln	MOUSE|MGI=MGI=107164|UniProtKB=P63328	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	RCA	7532676	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00226	Delta/Serrate	PANTR|Ensembl=ENSPTRG00000013250|UniProtKB=H2QJZ0	Delta-like protein	ISS	7697721	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00736	CalDAG-GEF	BOVIN|Gene=RASGRP2|UniProtKB=A6N9I4	RAS guanyl-releasing protein 2	ISS	10835426	PubMed	PTHR23113:SF16	RAS GUANYL-RELEASING PROTEIN 2
P00018	EGF receptor signaling pathway	P00547	PP2A	DANRE|ZFIN=ZDB-GENE-040426-877|UniProtKB=F1Q6Z7	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00056	VEGF signaling pathway	P01408	Akt/PKB	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MOUSE|MGI=MGI=107848|UniProtKB=Q9D6F9	Tubulin beta-4A chain	ISS	12932731	PubMed	PTHR11588:SF253	TUBULIN BETA-4A CHAIN
P00054	Toll receptor signaling pathway	P01341	Elk1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	ISS	10487205	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00547	PP2A	STRPU|EnsemblGenome=SPU_025182|UniProtKB=W4ZAK5	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	ORNAN|Ensembl=ENSOANG00000000818|UniProtKB=F6PLI7	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	XENTR|Xenbase=XB-GENE-976753|UniProtKB=Q0VFR6	Syntaxin 1A (Brain)	ISS	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00056	VEGF signaling pathway	P01411	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	PANTR|Ensembl=ENSPTRG00000014365|UniProtKB=H2R0C8	Casein kinase 1, epsilon	ISS	11865049	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	PANTR|Ensembl=ENSPTRG00000004079|UniProtKB=H2R1Z2	Uncharacterized protein	ISS	4757780	gi	PTHR11792:SF22	BETA-ARRESTIN-1
P04393	Ras Pathway	P04557	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00059	p53 pathway	P01486	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01182	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00015	Circadian clock system	G01499	per	CHICK|Ensembl=ENSGALG00000000573|UniProtKB=E1C8E2	Uncharacterized protein	ISS			PTHR11269:SF13	PERIOD CIRCADIAN PROTEIN HOMOLOG 3
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	MACMU|Ensembl=ENSMMUG00000003370|UniProtKB=F7E8G2	Uncharacterized protein	ISS	12787506	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1718748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00543	ERK1-2	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00541	Spry	HUMAN|HGNC=11270|UniProtKB=O43597	Protein sprouty homolog 2	IGI	12815057	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DICPU|Gene=DICPUDRAFT_92985|UniProtKB=F1A084	Putative uncharacterized protein rac1A	ISS	12932731	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00052	TGF-beta signaling pathway	P01286	TGFbeta	PANTR|Ensembl=ENSPTRG00000018300|UniProtKB=H2QT84	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF139	BONE MORPHOGENETIC PROTEIN 5
P00057	Wnt signaling pathway	P01447	Dishevelled	HUMAN|HGNC=3084|UniProtKB=O14640	Segment polarity protein dishevelled homolog DVL-1	ISS	12549854	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P00057	Wnt signaling pathway	P01438	PP2A	BOVIN|Ensembl=ENSBTAG00000000469|UniProtKB=P67774	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	HUMAN|HGNC=6696|UniProtKB=O75096	Low-density lipoprotein receptor-related protein 4	IDA	11907044	PubMed	PTHR44017:SF4	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4
P00014	Cholesterol biosynthesis	P00496	Diphosphomevalonate decarboxylase	MACMU|Ensembl=ENSMMUG00000014326|UniProtKB=F7D4H8	Diphosphomevalonate decarboxylase	ISS	P53602	SPACC	PTHR10977:SF3	DIPHOSPHOMEVALONATE DECARBOXYLASE
P00011	Blood coagulation	P00415	Plasmin	MOUSE|MGI=MGI=97620|UniProtKB=P20918	Plasminogen	ISS	15928602	gi	PTHR24261:SF5	PLASMINOGEN
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MACMU|Ensembl=ENSMMUG00000019342|UniProtKB=F6PVY4	Uncharacterized protein	ISS	12963527	gi	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	11251832	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	TAKRU|Ensembl=ENSTRUG00000005608|UniProtKB=H2SM93	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00056	VEGF signaling pathway	P01407	Erk	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02722	Acetate utilization	P02801	Acetate kinase	DEIRA|EnsemblGenome=DR_2602|UniProtKB=Q9RR92	Acetate kinase	ISS			PTHR21060:SF15	ACETATE KINASE
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MOUSE|MGI=MGI=87937|UniProtKB=P34971	Beta-1 adrenergic receptor	IDA	12730078	PubMed	PTHR24248:SF54	BETA-1 ADRENERGIC RECEPTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	IDA	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	CHICK|Ensembl=ENSGALG00000002719|UniProtKB=E1BVW0	Uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00057	Wnt signaling pathway	P01435	SWI/SNF	BOVIN|Ensembl=ENSBTAG00000015308|UniProtKB=A5PKF6	SMARCE1 protein	ISS	11532957	PubMed	PTHR13711:SF206	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY E MEMBER 1
P00054	Toll receptor signaling pathway	P01352	p38	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MACMU|Ensembl=ENSMMUG00000001661|UniProtKB=F7GR69	Uncharacterized protein	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06794	MAP2K1/2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	RCA	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00561	STAT	PANTR|Ensembl=ENSPTRG00000005095|UniProtKB=H2Q688	Signal transducer and activator of transcription	ISS			PTHR11801:SF41	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 2
P00053	T cell activation	P01307	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00023	General transcription regulation	P00668	TFIIB	CANLF|Ensembl=ENSCAFG00000008517|UniProtKB=E2R3J4	Uncharacterized protein	ISS			PTHR12458:SF8	CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS			PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00012	Cadherin signaling pathway	P00477	GSK3beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	RAT|RGD=67385|UniProtKB=Q8VGC3	Voltage-dependent L-type calcium channel subunit beta-2	ISS	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00053	T cell activation	P01318	PKC-theta	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00006	Apoptosis signaling pathway	P00303	c-Jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	12972619	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	ARATH|TAIR=AT5G15570|UniProtKB=Q9LF25	Bromodomain transcription factor	ISS	604903	OMIM	PTHR12321:SF53	BROMODOMAIN TRANSCRIPTION FACTOR
P00047	PDGF signaling pathway	P01164	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00030	Hypoxia response via HIF activation	P00825	Thioredoxin	DROME|FlyBase=FBgn0011761|UniProtKB=P47938	Thioredoxin-1	ISS	12115731	PubMed	PTHR10438:SF359	THIOREDOXIN
P00023	General transcription regulation	P00666	TFIIE	MACMU|Ensembl=ENSMMUG00000001596|UniProtKB=F7GV34	General transcription factor IIE subunit 1	ISS	189964	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	LEIMA|EnsemblGenome=LmjF.35.3960|UniProtKB=E9AFM1	Protein kinase A catalytic subunit isoform 2	ISS	10553940	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01173	STAT	CHICK|Ensembl=ENSGALG00000003267|UniProtKB=Q6DV79	Signal transducer and activator of transcription 3	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Gene=PLCD4|UniProtKB=P21671	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	10934033	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00023	General transcription regulation	P00660	RNA Polymerase II	ARATH|TAIR=AT3G54490|UniProtKB=Q9M1H8	DNA-directed RNA polymerase V subunit 5C	ISS	11313498	PubMed	PTHR10535:SF6	DNA-DIRECTED RNA POLYMERASE V SUBUNIT 5C
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	IGI	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MACMU|Ensembl=ENSMMUG00000000289|UniProtKB=F7A9T0	Uncharacterized protein	ISS	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IGI	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CHICK|Ensembl=ENSGALG00000014539|UniProtKB=F1N861	Uncharacterized protein	ISS	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	ARATH|TAIR=AT1G80360|UniProtKB=Q9C969	At1g80360	ISS			PTHR43795:SF12	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01173	STAT	CHICK|Ensembl=ENSGALG00000003267|UniProtKB=Q6DV79	Signal transducer and activator of transcription 3	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DROME|FlyBase=FBgn0259680|UniProtKB=P83099	Putative protein kinase C delta type homolog	ISS	3755548	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00059	p53 pathway	P01486	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P06216	SCW signaling pathway	P06331	MAD	DROME|FlyBase=FBgn0011648|UniProtKB=P42003	Protein mothers against dpp	IGI	7768443	PubMed	PTHR13703:SF40	PROTEIN MOTHERS AGAINST DPP
P00010	B cell activation	P00398	IP3R	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	IGI	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF31	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01408	Akt/PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00774	Dynein complex	CANLF|Ensembl=ENSCAFG00000001370|UniProtKB=E2RL64	Uncharacterized protein	ISS	9454836	PubMed	PTHR11886:SF2	DYNEIN LIGHT CHAIN 4, AXONEMAL
P00052	TGF-beta signaling pathway	P01275	P38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	TAS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01145	c-fos	MACMU|Ensembl=ENSMMUG00000010574|UniProtKB=A5A6H2	C-fos	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	CANLF|Ensembl=ENSCAFG00000010787|UniProtKB=E2R3W6	Uncharacterized protein	ISS	11248120	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00047	PDGF signaling pathway	P01143	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00634	MEKK1-5	PANTR|Ensembl=ENSPTRG00000012427|UniProtKB=H2QIN7	Mitogen-activated protein kinase kinase kinase 2	ISS	21735556	gi	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	IDA	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00047	PDGF signaling pathway	P01150	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05913	Enkephalin release	P05972	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	IC	15860573	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P06959	CCKR signaling map	G07293	ITGAV	HUMAN|HGNC=6150|UniProtKB=P06756	Integrin alpha-V	RCA	22110279	PubMed	PTHR23220:SF4	INTEGRIN ALPHA-V
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00021	FGF signaling pathway	P00623	FGF	MOUSE|MGI=MGI=109167|UniProtKB=P70378	Fibroblast growth factor 11	ISS	8790420	PubMed	PTHR11486:SF67	FIBROBLAST GROWTH FACTOR 11
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	DANRE|ZFIN=ZDB-GENE-040718-93|UniProtKB=Q6DGZ5	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P05918	p38 MAPK pathway	P06031	p38alpha	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	RCA	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00206	Wnt	MACMU|Ensembl=ENSMMUG00000018445|UniProtKB=F7HEW6	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	DAPPU|EnsemblGenome=DAPPUDRAFT_230475|UniProtKB=E9G2Q6	Putative uncharacterized protein	ISS			PTHR23431:SF3	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5
P00006	Apoptosis signaling pathway	P00297	NFkappaB	HUMAN|HGNC=7795|UniProtKB=Q00653	Nuclear factor NF-kappa-B p100 subunit	ISS	9133421	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	MOUSE|MGI=MGI=97364|UniProtKB=O35516	Neurogenic locus notch homolog protein 2	IDA	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00052	TGF-beta signaling pathway	P01284	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01152	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	2574500	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04398	p53 pathway feedback loops 2	P04651	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P00021	FGF signaling pathway	P00641	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00029	Huntington disease	P00777	CBP	ARATH|TAIR=AT1G67220|UniProtKB=Q9FYH1	Histone acetyltransferase HAC2	IDA	10823891	PubMed	PTHR13808:SF6	HISTONE ACETYLTRANSFERASE HAC2
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05950	DARPP-32	MOUSE|MGI=MGI=94860|UniProtKB=Q60829	Protein phosphatase 1 regulatory subunit 1B	ISS	3339428	PubMed	PTHR15417:SF2	PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 1B
P00054	Toll receptor signaling pathway	P01346	TLR	PANTR|Ensembl=ENSPTRG00000021667|UniProtKB=H2R4T6	Uncharacterized protein	ISS			PTHR44312:SF2	TOLL-LIKE RECEPTOR 8
P00029	Huntington disease	P00790	beta-Tubulin	NEMVE|Gene=v1g118944|UniProtKB=A7SHY4	Predicted protein (Fragment)	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00006	Apoptosis signaling pathway	P00318	PKCs	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00012	Cadherin signaling pathway	P00471	Cadherin	MONDO|Ensembl=ENSMODG00000004237|UniProtKB=F6UBJ7	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF99	CADHERIN-9
P00048	PI3 kinase pathway	P01181	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	RAT|RGD=2744|UniProtKB=P31422	Metabotropic glutamate receptor 3	ISS	9407094	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P04393	Ras Pathway	P04558	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00053	T cell activation	P01300	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	HUMAN|HGNC=361|UniProtKB=P00568	Adenylate kinase isoenzyme 1	ISS			PTHR23359:SF59	ADENYLATE KINASE ISOENZYME 1
P04393	Ras Pathway	P04557	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IDA	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	HUMAN|HGNC=19663|UniProtKB=Q9UBI6	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00381	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04565	MKK4/7	CANLF|Ensembl=ENSCAFG00000017851|UniProtKB=F1PBB6	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00047	PDGF signaling pathway	P01173	STAT	TAKRU|Ensembl=ENSTRUG00000015348|UniProtKB=H2UQK9	Signal transducer and activator of transcription	ISS	11879641	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	CANLF|Ensembl=ENSCAFG00000016077|UniProtKB=E2QW66	Receptor protein serine/threonine kinase	ISS	10683140	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P06959	CCKR signaling map	P07232	CREB1	HUMAN|HGNC=2345|UniProtKB=P16220	Cyclic AMP-responsive element-binding protein 1	RCA	18813292	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	BOVIN|Ensembl=ENSBTAG00000018705|UniProtKB=F1MPC9	Uncharacterized protein	ISS	2255909	PubMed	PTHR11920:SF291	ADENYLATE CYCLASE TYPE 3
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P05918	p38 MAPK pathway	P06030	IL-1R	MACMU|Ensembl=ENSMMUG00000020737|UniProtKB=F7GVA6	Uncharacterized protein	ISS			PTHR11890:SF26	INTERLEUKIN-1 RECEPTOR TYPE 1
P05730	Endogenous cannabinoid signaling	P05746	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	CANLF|Ensembl=ENSCAFG00000015905|UniProtKB=E2QUH6	Uncharacterized protein	ISS	11742073	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	PANTR|Ensembl=ENSPTRG00000002979|UniProtKB=H2Q2M8	Uncharacterized protein	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00054	Toll receptor signaling pathway	P01351	TLR2,4,7	HUMAN|HGNC=15631|UniProtKB=Q9NYK1	Toll-like receptor 7	ISS			PTHR44312:SF1	TOLL-LIKE RECEPTOR 7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	ANOGA|EnsemblGenome=AGAP001712|UniProtKB=Q7PUF2	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00048	PI3 kinase pathway	P01192	p110	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00029	Huntington disease	P00786	ARF	CAEBR|Gene=CBG21511|UniProtKB=A8Y0A3	Protein CBR-ARL-8	ISS	12932731	PubMed	PTHR11711:SF20	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	CANLF|Ensembl=ENSCAFG00000009203|UniProtKB=F1PVZ1	Muscarinic acetylcholine receptor	ISS	91373358	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	ANOGA|Gene=AgaP_AGAP009115|UniProtKB=Q7PW25	Phosphoinositide phospholipase C (Fragment)	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00016	Cytoskeletal regulation by Rho GTPase	P00521	Profilin	BOVIN|Ensembl=ENSBTAG00000018312|UniProtKB=E1BHJ0	Profilin	ISS			PTHR13936:SF14	PROFILIN-1
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	TAS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01428	Frizzled	DANRE|ZFIN=ZDB-GENE-000328-3|UniProtKB=Q9YI00	Frizzled 8a protein	IDA	11212302	PubMed	PTHR11309:SF90	FRIZZLED-8
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=2136730|UniProtKB=Q91Y08	Protein Pcdhb1	IDA	8120095	PubMed	PTHR24028:SF12	PROTOCADHERIN BETA-1
P00034	Integrin signalling pathway	P00924	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02775	Salvage pyrimidine ribonucleotides	P03150	Uridine kinase	ANOGA|EnsemblGenome=AGAP005209|UniProtKB=Q5TSQ7	Uridine kinase	ISS			PTHR10285:SF123	URIDINE KINASE
P00052	TGF-beta signaling pathway	P01275	P38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	TAS	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00053	T cell activation	P01320	PLC-gamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000025240|UniProtKB=F7A7I3	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00047	PDGF signaling pathway	P01174	Rho	HUMAN|HGNC=673|UniProtKB=Q07960	Rho GTPase-activating protein 1	ISS	14724572	PubMed	PTHR23176:SF28	RHO GTPASE-ACTIVATING PROTEIN 1
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00624	14-3-3	HUMAN|HGNC=12852|UniProtKB=P61981	14-3-3 protein gamma	IGI	10407019	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	RAT|RGD=1309329|UniProtKB=F1MAD0	Protein Lrp5	ISS	11907044	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00012	Cadherin signaling pathway	P00470	F-actin	MACMU|Ensembl=ENSMMUG00000001353|UniProtKB=F7D6T8	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00034	Integrin signalling pathway	P00907	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00037	Ionotropic glutamate receptor pathway	P01026	KA	HUMAN|HGNC=4581|UniProtKB=Q13003	Glutamate receptor ionotropic, kainate 3	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00037	Ionotropic glutamate receptor pathway	P01023	CaMKII	PANTR|Ensembl=ENSPTRG00000016383|UniProtKB=H2QQ24	Calcium/calmodulin-dependent protein kinase II delta	ISS	12888804	PubMed	PTHR43940:SF4	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT DELTA
P04393	Ras Pathway	P04558	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	12810719	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00036	Interleukin signaling pathway	P00966	mTOR	BOVIN|Ensembl=ENSBTAG00000015325|UniProtKB=E1BFB4	Uncharacterized protein	ISS	14526383	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00047	PDGF signaling pathway	P01143	ERK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00056	VEGF signaling pathway	P01408	Akt/PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00577	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MACMU|Ensembl=ENSMMUG00000010392|UniProtKB=F7ASR8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00036	Interleukin signaling pathway	P00970	Interleukin	MOUSE|MGI=MGI=96548|UniProtKB=P04351	Interleukin-2	IC			PTHR45426:SF1	INTERLEUKIN-2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00627	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00034	Integrin signalling pathway	P00951	Jnk	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00034	Integrin signalling pathway	P00941	Integrin alpha	RAT|RGD=1311191|UniProtKB=D3ZN51	Protein Itga9	ISS	3487386	PubMed	PTHR23220:SF69	INTEGRIN ALPHA-9
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	MACMU|Ensembl=ENSMMUG00000001758|UniProtKB=F6TN15	Uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF84	CASEIN KINASE I ISOFORM ALPHA
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	MACMU|Ensembl=ENSMMUG00000012470|UniProtKB=F7G0B2	Uncharacterized protein	ISS	604904	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00018	EGF receptor signaling pathway	P00559	MEK1-2	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00006	Apoptosis signaling pathway	P00260	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00796	Kainate receptor	RAT|RGD=2733|UniProtKB=P42260	Glutamate receptor ionotropic, kainate 2	IDA	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	IDA	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	MOUSE|MGI=MGI=2385459|UniProtKB=O54928	Suppressor of cytokine signaling 5	IDA	22247722	PubMed	PTHR44282:SF3	SUPPRESSOR OF CYTOKINE SIGNALING 5
P00021	FGF signaling pathway	P00643	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00045	Notch signaling pathway	G01541	E(spl)-C genes	DROME|FlyBase=FBgn0002735|UniProtKB=Q01070	Enhancer of split mgamma protein	TAS	14973298	PubMed	PTHR10985:SF12	ENHANCER OF SPLIT M3 PROTEIN-RELATED
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P02781	Threonine biosynthesis	P03191	Homoserine kinase	DEIRA|EnsemblGenome=DR_2390|UniProtKB=Q9RRU5	Homoserine kinase	ISS			PTHR20861:SF1	HOMOSERINE KINASE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00049	Parkinson disease	P01242	Casein kinase I	DROME|FlyBase=FBgn0015024|UniProtKB=P54367	Casein kinase I isoform alpha	IDA	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MOUSE|MGI=MGI=3609260|UniProtKB=B2RX82	Cholinergic receptor, nicotinic, alpha polypeptide 10	ISS			PTHR18945:SF768	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-10
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00010	B cell activation	P00381	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01355	AP1	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00059	p53 pathway	P04635	Sumo-1 ligase	XENTR|Xenbase=XB-GENE-978491|UniProtKB=Q6DEP7	Small ubiquitin-related modifier 1	ISS			PTHR10562:SF52	SMALL UBIQUITIN-RELATED MODIFIER 1
P00038	JAK/STAT signaling pathway	P01031	PIAS	RAT|RGD=708413|UniProtKB=O70260	E3 SUMO-protein ligase PIAS3	ISS	8682149	PubMed	PTHR10782:SF10	E3 SUMO-PROTEIN LIGASE PIAS3
P00010	B cell activation	P00379	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00019	Endothelin signaling pathway	P00586	Gq	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000002647|UniProtKB=F7DIB7	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01154	Ras	YEAST|SGD=S000005627|UniProtKB=P01119	Ras-like protein 1	ISS	7997267	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00045	Notch signaling pathway	P01101	Su(H)	XENTR|Xenbase=XB-GENE-490756|UniProtKB=F7BXC9	Uncharacterized protein (Fragment)	ISS	9043084	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	DANRE|ZFIN=ZDB-GENE-980526-352|UniProtKB=P47793	Protein Wnt-4a	TAS	8717036	PubMed	PTHR12027:SF103	PROTEIN WNT-4A
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	CANLF|Ensembl=ENSCAFG00000002732|UniProtKB=E2QUQ3	CTP synthase	ISS			PTHR11550:SF8	CTP SYNTHASE 1
P00047	PDGF signaling pathway	P01159	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	TAS	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00060	Ubiquitin proteasome pathway	P01491	E2	ARATH|TAIR=AT5G59300|UniProtKB=Q42540	Ubiquitin-conjugating enzyme E2 7	ISS			PTHR24067:SF237	UBIQUITIN-CONJUGATING ENZYME E2 13-RELATED
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00057	Wnt signaling pathway	P01448	CBP	ARATH|TAIR=AT1G16710|UniProtKB=Q9FWQ5	Histone acetyltransferase HAC12	ISS	10664585	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00034	Integrin signalling pathway	P00941	Integrin alpha	CHICK|Gene=ITGAV|UniProtKB=P26008	Integrin alpha-V	IPI	3487386	PubMed	PTHR23220:SF4	INTEGRIN ALPHA-V
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00056	VEGF signaling pathway	P01413	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	ISS	9620264	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	BOVIN|Gene=MYH7|UniProtKB=Q9BE39	Myosin-7	IEP	89264452	PubMed	PTHR13140:SF344	MYOSIN-7
P02781	Threonine biosynthesis	P03190	Threonine synthase	SYNY3|EnsemblGenome=BAA18282|UniProtKB=P74193	Threonine synthase	ISS			PTHR10314:SF5	THREONINE SYNTHASE 1, CHLOROPLASTIC
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=11333|UniProtKB=P31391	Somatostatin receptor type 4	IDA	12181435	PubMed	PTHR24229:SF52	SOMATOSTATIN RECEPTOR TYPE 4
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	TAS			PTHR24055:SF330	SUBFAMILY NOT NAMED
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	RAT|RGD=621116|UniProtKB=Q62880	Transcription initiation factor TFIID subunit 9B	ISS			PTHR12595:SF3	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 9B
P04393	Ras Pathway	P04556	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P02785	Valine biosynthesis	P03217	Dihydroxy isovalerate reductoisomerase	NEUCR|EnsemblGenome=EFNCRG00000003422|UniProtKB=P38674	Ketol-acid reductoisomerase, mitochondrial	ISS			PTHR21371:SF13	KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL
P00034	Integrin signalling pathway	P00940	Src	HUMAN|HGNC=11283|UniProtKB=P12931	Proto-oncogene tyrosine-protein kinase Src	IPI	8054685	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P04376	5HT4 type receptor mediated signaling pathway	P04427	5HT4 Receptor	PANTR|Ensembl=ENSPTRG00000017389|UniProtKB=H2R334	Uncharacterized protein	ISS	15118808	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P00012	Cadherin signaling pathway	P00470	F-actin	RAT|RGD=2027|UniProtKB=P63269	Actin, gamma-enteric smooth muscle	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00029	Huntington disease	P00790	beta-Tubulin	ARATH|TAIR=AT4G20890|UniProtKB=P29517	Tubulin beta-9 chain	TAS	12932731	PubMed	PTHR11588:SF245	TUBULIN BETA-4 CHAIN-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00053	T cell activation	P01322	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00631	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	8262390	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P02741	Flavin biosynthesis	P02939	Lumazine synthase	FUSNN|EnsemblGenome=FN1505|UniProtKB=Q8RIR4	6,7-dimethyl-8-ribityllumazine synthase	ISS			PTHR21058:SF0	6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000010143|UniProtKB=F6QXA9	Uncharacterized protein	ISS	11554554	PubMed	PTHR24356:SF175	SERINE/THREONINE-PROTEIN KINASE N3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IDA	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04398	p53 pathway feedback loops 2	P04651	Ras	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	IDA	22097630	PubMed	PTHR24070:SF189	GTPASE NRAS
P02769	Purine metabolism	P03118	Guanine Deaminase	MACMU|Ensembl=ENSMMUG00000019196|UniProtKB=F7CWS1	Guanine deaminase isoform b	ISS	7533042	gi	PTHR11271:SF6	GUANINE DEAMINASE
P00021	FGF signaling pathway	P00624	14-3-3	ORYSJ|EnsemblGenome=OS01G0209200|UniProtKB=Q5QNB8	14-3-3-like protein GF14-G	ISS	10407019	PubMed	PTHR18860:SF32	14-3-3 FAMILY PROTEIN-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CANLF|Ensembl=ENSCAFG00000015708|UniProtKB=F2Z4N0	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00047	PDGF signaling pathway	P01167	Ets	MOUSE|MGI=MGI=95455|UniProtKB=P27577	Protein C-ets-1	ISS	3060801	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00018	EGF receptor signaling pathway	P00552	Ras	CHICK|Ensembl=ENSGALG00000014033|UniProtKB=E1BTS2	Uncharacterized protein	ISS	9869449	PubMed	PTHR24070:SF186	GTPASE KRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	MACMU|Ensembl=ENSMMUG00000008587|UniProtKB=F6UGY3	Calcium/calmodulin-dependent protein kinase type II subunit delta isoform 3	ISS	12888804	PubMed	PTHR43940:SF4	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT DELTA
P04398	p53 pathway feedback loops 2	P04660	SIAH-1	MOUSE|MGI=MGI=108063|UniProtKB=Q06985	E3 ubiquitin-protein ligase SIAH1B	ISS	15326481	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	CHICK|Ensembl=ENSGALG00000014975|UniProtKB=F1NTE9	Uncharacterized protein	ISS	11861492	PubMed	PTHR43893:SF8	D 1B  DOPAMINE RECEPTOR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00718	Phosphorylase a	CHICK|Ensembl=ENSGALG00000008508|UniProtKB=E1BSN7	Alpha-1,4 glucan phosphorylase	ISS	4318782	PubMed	PTHR11468:SF1	GLYCOGEN PHOSPHORYLASE, BRAIN FORM
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00056	VEGF signaling pathway	P01408	Akt/PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01236	Casein kinase II	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g245041|UniProtKB=A7SG27	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00059	p53 pathway	P01486	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04397	p53 pathway by glucose deprivation	P04641	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00059	p53 pathway	P04609	PI3K	CAEEL|WormBase=WBGene00006932|UniProtKB=Q9TXI7	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	11927551	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00005	Angiogenesis	P00221	JNK1	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00012	Cadherin signaling pathway	P00470	F-actin	PHYIT|EnsemblGenome=PITG_15078|UniProtKB=D0NRL5	Actin-like protein	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00036	Interleukin signaling pathway	P00974	Receptor subunit beta	HUMAN|HGNC=6009|UniProtKB=P14784	Interleukin-2 receptor subunit beta	IC	11238664	PubMed	PTHR23037:SF30	INTERLEUKIN-2 RECEPTOR SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ORYSJ|EnsemblGenome=OS06G0699400|UniProtKB=Q5Z859	Mitogen-activated protein kinase 4	ISS	11707292	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P02721	ATP synthesis	P02798	Cyt C	ORNAN|Ensembl=ENSOANG00000009156|UniProtKB=F7EJM9	Uncharacterized protein	ISS	4347193	PubMed	PTHR11961:SF12	CYTOCHROME C
P00036	Interleukin signaling pathway	P00976	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	BOVIN|Gene=SOCS5|UniProtKB=Q29RN6	Suppressor of cytokine signaling 5	ISS	15032587	PubMed	PTHR44282:SF3	SUPPRESSOR OF CYTOKINE SIGNALING 5
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00866	Cytokine receptor	MOUSE|MGI=MGI=107655|UniProtKB=P15261	Interferon gamma receptor 1	IDA	11358460	PubMed	PTHR20859:SF5	INTERFERON GAMMA RECEPTOR 1
P00021	FGF signaling pathway	P00644	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	HUMAN|HGNC=4598|UniProtKB=O15303	Metabotropic glutamate receptor 6	ISS	11431030	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04585	TRH	MOUSE|MGI=MGI=98848|UniProtKB=P12656	Thyrotropin subunit beta	ISS			PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00049	Parkinson disease	P01207	PLD2	MACMU|Ensembl=ENSMMUG00000005666|UniProtKB=F6VWY6	Uncharacterized protein	ISS	15030398	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P00057	Wnt signaling pathway	P01465	Ggamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00052	TGF-beta signaling pathway	P01275	P38	CAEBR|Gene=CBG01555|UniProtKB=A8WRD7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00029	Huntington disease	P00796	Kainate receptor	HUMAN|HGNC=4579|UniProtKB=P39086	Glutamate receptor ionotropic, kainate 1	IDA	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04393	Ras Pathway	P04556	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00024	Glycolysis	P00678	Enolase	DANRE|ZFIN=ZDB-GENE-030131-6048|UniProtKB=Q6PC12	Enolase 1, (Alpha)	ISS	89079778	PubMed	PTHR11902:SF12	ALPHA-ENOLASE
P00018	EGF receptor signaling pathway	P00552	Ras	MONDO|Gene=KRAS|UniProtKB=Q07983	GTPase KRas	ISS	99084794	PubMed	PTHR24070:SF186	GTPASE KRAS
P00047	PDGF signaling pathway	P01143	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00059	p53 pathway	P01485	p53	MOUSE|MGI=MGI=1336991|UniProtKB=Q9JJP2	Tumor protein p73	TAS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00006	Apoptosis signaling pathway	P00297	NFkappaB	RAT|RGD=727889|UniProtKB=Q7TQN4	Protein Rela	ISS	10049353	PubMed	PTHR24169:SF1	TRANSCRIPTION FACTOR P65
P00034	Integrin signalling pathway	P00924	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IPI	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P06959	CCKR signaling map	P07042	CCK2R	HUMAN|HGNC=1571|UniProtKB=P32239	Gastrin/cholecystokinin type B receptor	RCA	8995203	PubMed	PTHR24243:SF45	GASTRIN/CHOLECYSTOKININ TYPE B RECEPTOR
P00059	p53 pathway	P01486	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00053	T cell activation	P01320	PLC-gamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MACMU|Ensembl=ENSMMUG00000000016|UniProtKB=F7HTL0	Adenylosuccinate synthetase isozyme 2	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	HUMAN|HGNC=4242|UniProtKB=O94808	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2	ISS			PTHR10937:SF10	GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE  ISOMERIZING  2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00046	Oxidative stress response	P01135	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	TAS	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000012036|UniProtKB=F7ALP1	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P02770	Pyridoxal phosphate salvage pathway	P03120	Pyridoxamine-5-phosphate oxidase	MOUSE|MGI=MGI=2144151|UniProtKB=Q91XF0	Pyridoxine-5'-phosphate oxidase	ISS	9601034	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00034	Integrin signalling pathway	P00942	Fyn	MACMU|Ensembl=ENSMMUG00000017017|UniProtKB=F7FVL2	Tyrosine-protein kinase	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	ISS	10553940	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00021	FGF signaling pathway	P00627	ERK1-2	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00626	Spry	RAT|RGD=1311472|UniProtKB=Q5HZA2	Protein Spry2	ISS	12225946	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P00048	PI3 kinase pathway	P01199	Galpha	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	IC	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04393	Ras Pathway	P04578	Rho	HUMAN|HGNC=669|UniProtKB=P08134	Rho-related GTP-binding protein RhoC	IDA	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00005	Angiogenesis	P00223	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05916	Opioid prodynorphin pathway	P06002	G-protein	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	ORNAN|Ensembl=ENSOANG00000012115|UniProtKB=F7F9Q9	Uncharacterized protein	ISS	10806215	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00034	Integrin signalling pathway	P00920	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00046	Oxidative stress response	P01125	Stat1	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	14984365	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00010	B cell activation	P00375	Calmodulin	PUCGT|EnsemblGenome=PGTG_11337|UniProtKB=E3KLJ3	Calmodulin	ISS			PTHR23050:SF245	AT16150P-RELATED
P00037	Ionotropic glutamate receptor pathway	P00998	stargazin	PANTR|Ensembl=ENSPTRG00000014315|UniProtKB=H2QLK9	Voltage-dependent calcium channel gamma subunit	RCA			PTHR12107:SF1	VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-2 SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05915	Opioid proenkephalin pathway	P05994	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	ISS	10571227	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00022	General transcription by RNA polymerase I	P00651	TAF-IA	MONDO|Ensembl=ENSMODG00000012785|UniProtKB=F6S0M5	Uncharacterized protein	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	SCHPO|PomBase=SPBC1347.06c|UniProtKB=P40233	Casein kinase I homolog 1	IDA	10617630	PubMed	PTHR11909:SF155	GILGAMESH, ISOFORM L
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00402	Jnk	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01154	Ras	ORNAN|Ensembl=ENSOANG00000008835|UniProtKB=F7FR08	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DROME|FlyBase=FBgn0030011|UniProtKB=Q9W3J1	Gbeta5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00059	p53 pathway	G04694	p110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04541	p90RSK	PANTR|Ensembl=ENSPTRG00000000387|UniProtKB=H2PYE3	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P04393	Ras Pathway	P04567	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IDA	12660731	PubMed	PTHR10048:SF14	PI-3 KINASE
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	MACMU|Ensembl=ENSMMUG00000001731|UniProtKB=F7GN87	Uncharacterized protein	ISS			PTHR10937:SF10	GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE  ISOMERIZING  2
P00011	Blood coagulation	P00445	FXa	HUMAN|HGNC=3528|UniProtKB=P00742	Coagulation factor X	ISS	4503625	gi	PTHR44064:SF3	COAGULATION FACTOR X
P05913	Enkephalin release	P05974	G-Protein (i)	BOVIN|Ensembl=ENSBTAG00000035697|UniProtKB=Q28024	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	MACMU|Ensembl=ENSMMUG00000010761|UniProtKB=F7FXK5	Uncharacterized protein	ISS	9718352	PubMed	PTHR11647:SF50	DIHYDROPYRIMIDINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01080	AChE	CAEEL|WormBase=WBGene00000038|UniProtKB=G5EDN1	Carboxylic ester hydrolase	IC			PTHR43918:SF2	CARBOXYLIC ESTER HYDROLASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	RAT|RGD=621316|UniProtKB=P33436	72 kDa type IV collagenase	TAS	12834808	PubMed	PTHR10201:SF29	72 KDA TYPE IV COLLAGENASE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MONDO|Ensembl=ENSMODG00000013970|UniProtKB=F6R6X5	Uncharacterized protein	ISS	11431030	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00737	Rap1GAP	HUMAN|HGNC=25425|UniProtKB=Q5VVW2	GTPase-activating Rap/Ran-GAP domain-like protein 3	IDA	10419452	PubMed	PTHR15711:SF31	GTPASE-ACTIVATING RAP/RAN-GAP DOMAIN-LIKE PROTEIN 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04570	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IGI	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000032222|UniProtKB=F7FW05	Uncharacterized protein	ISS	11701344	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00057	Wnt signaling pathway	P01465	Ggamma	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IDA	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00059	p53 pathway	G04694	p110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00060	Ubiquitin proteasome pathway	P01491	E2	BOVIN|Gene=UBE2L3|UniProtKB=Q3MHP1	Ubiquitin-conjugating enzyme E2 L3	ISS	10888878	PubMed	PTHR24068:SF67	UBIQUITIN-CONJUGATING ENZYME E2 L3
P00005	Angiogenesis	P00218	STAT1	DANRE|ZFIN=ZDB-GENE-980526-499|UniProtKB=Q6P943	Signal transducer and activator of transcription	ISS	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00056	VEGF signaling pathway	P01409	cPLA2	MONDO|Ensembl=ENSMODG00000011791|UniProtKB=F7CBU9	Phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00059	p53 pathway	G04699	BAI-1	BOVIN|Ensembl=ENSBTAG00000010657|UniProtKB=E1B9M5	Uncharacterized protein	ISS			PTHR12011:SF41	ADHESION G PROTEIN-COUPLED RECEPTOR B2
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00052	TGF-beta signaling pathway	P01286	TGFbeta	PANTR|Ensembl=ENSPTRG00000019116|UniProtKB=H2QUH0	Inhibin, beta A	ISS	11451570	PubMed	PTHR11848:SF133	INHIBIN BETA A CHAIN
P00029	Huntington disease	P00780	Microtubule	HUMAN|HGNC=20774|UniProtKB=P04350	Tubulin beta-4A chain	IDA	9454836	PubMed	PTHR11588:SF253	TUBULIN BETA-4A CHAIN
P02741	Flavin biosynthesis	P02939	Lumazine synthase	BACTN|EnsemblGenome=BT_4253|UniProtKB=Q89ZW8	6,7-dimethyl-8-ribityllumazine synthase	ISS			PTHR21058:SF0	6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CAEEL|WormBase=WBGene00002041|UniProtKB=U4PBY2	Heavy chain, Unconventional Myosin	IC			PTHR13140:SF706	UNCONVENTIONAL MYOSIN-VI
P00059	p53 pathway	G01579	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	TAS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	MACMU|Ensembl=ENSMMUG00000017022|UniProtKB=F7HQZ9	Uncharacterized protein	ISS	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P04398	p53 pathway feedback loops 2	P04657	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00568	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	IGI	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	STRPU|EnsemblGenome=SPU_006797|UniProtKB=W4XTP5	Uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	PANTR|Ensembl=ENSPTRG00000003901|UniProtKB=H2Q449	Uncharacterized protein	ISS	10664585	PubMed	PTHR23351:SF6	FOS-RELATED ANTIGEN 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MOUSE|MGI=MGI=1098434|UniProtKB=O08850	Regulator of G-protein signaling 5	IDA	8756726	PubMed	PTHR10845:SF42	REGULATOR OF G-PROTEIN SIGNALING 5
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00054	Toll receptor signaling pathway	G01550	Gene trancription	CANLF|Ensembl=ENSCAFG00000013762|UniProtKB=Q8SPQ9	Cyclooxygenase 2	ISS	12163371	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00017	DNA replication	P00534	PCNA	SULSO|EnsemblGenome=SSO0397|UniProtKB=P57766	DNA polymerase sliding clamp 1	ISS	21332296	PubMed	PTHR11352:SF0	PROLIFERATING CELL NUCLEAR ANTIGEN
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ARATH|TAIR=AT4G29040|UniProtKB=Q9SZD4	26S proteasome regulatory subunit 4 homolog A	ISS			PTHR23073:SF24	26S PROTEASE REGULATORY SUBUNIT 4
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00048	PI3 kinase pathway	P01181	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00045	Notch signaling pathway	P01103	Next	MONDO|Ensembl=ENSMODG00000004910|UniProtKB=F7C1Q4	Delta-like protein	ISS	12826675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00092	TACE	CANLF|Ensembl=ENSCAFG00000003383|UniProtKB=F1PFZ9	Uncharacterized protein	ISS	9774383	PubMed	PTHR11905:SF171	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00373	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04407	K+ channel	CHICK|Ensembl=ENSGALG00000016193|UniProtKB=E1BYI0	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TRIAD|EnsemblGenome=TriadG63375|UniProtKB=B3S5E4	Non-muscle actin 6.2	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	TAKRU|Ensembl=ENSTRUG00000005494|UniProtKB=P53483	Actin, alpha anomalous	IC	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00005	Angiogenesis	P00189	Fzd	MOUSE|MGI=MGI=108571|UniProtKB=Q9EQD0	Frizzled-5	ISS	8717036	PubMed	PTHR11309:SF126	FRIZZLED-5
P05915	Opioid proenkephalin pathway	P05993	AC	RAT|RGD=619966|UniProtKB=F1LQT1	Adenylate cyclase 7	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00029	Huntington disease	P00780	Microtubule	MACMU|Ensembl=ENSMMUG00000012546|UniProtKB=F7E840	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6878|UniProtKB=P31152	Mitogen-activated protein kinase 4	IDA	10514528	PubMed	PTHR24055:SF25	MITOGEN-ACTIVATED PROTEIN KINASE 4
P00047	PDGF signaling pathway	P01153	GSK3	SCHPO|PomBase=SPBC8D2.01|UniProtKB=Q9URT9	Protein kinase gsk31	ISS	12615961	PubMed	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00010	B cell activation	P00371	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	MACMU|Ensembl=ENSMMUG00000010184|UniProtKB=F6SR09	Uncharacterized protein	ISS	8314195	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P02785	Valine biosynthesis	P03218	Dihydroxy isovalerate dehydratase	GLOVI|EnsemblGenome=BAC91109|UniProtKB=Q7NGK1	Dihydroxy-acid dehydratase	ISS			PTHR21000:SF5	DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02775	Salvage pyrimidine ribonucleotides	P03150	Uridine kinase	HUMAN|HGNC=15938|UniProtKB=Q9NWZ5	Uridine-cytidine kinase-like 1	ISS			PTHR10285:SF68	URIDINE-CYTIDINE KINASE-LIKE 1
P05915	Opioid proenkephalin pathway	P05989	leu-Enkephalin	MOUSE|MGI=MGI=104629|UniProtKB=P22005	Proenkephalin-A	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00034	Integrin signalling pathway	P00922	Collagen	CAEEL|WormBase=WBGene00002280|UniProtKB=P17140	Collagen alpha-2(IV) chain	IDA	10778855	PubMed	PTHR24023:SF853	COLLAGEN ALPHA-2 IV  CHAIN
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	PHANO|EnsemblGenome=SNOG_16544|UniProtKB=Q0TVC0	Uncharacterized protein	ISS			PTHR23073:SF13	26S PROTEASE REGULATORY SUBUNIT 7
P00019	Endothelin signaling pathway	P00589	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IGI	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	P01431	LRP5/6	HUMAN|HGNC=6698|UniProtKB=O75581	Low-density lipoprotein receptor-related protein 6	IDA	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P06959	CCKR signaling map	P07209	TPC1/2	HUMAN|HGNC=18182|UniProtKB=Q9ULQ1	Two pore calcium channel protein 1	RCA	19387438	PubMed	PTHR10037:SF231	TWO PORE CALCIUM CHANNEL PROTEIN 1
P00053	T cell activation	P01333	cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00044	Nicotinic acetylcholine receptor signaling pathway	P01089	VAChT	ANOGA|EnsemblGenome=AGAP002369|UniProtKB=Q7PR83	AGAP002369-PA	ISS	21863848	PubMed	PTHR23506:SF13	VESICULAR ACETYLCHOLINE TRANSPORTER
P00036	Interleukin signaling pathway	P00965	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	IC	1169551	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01142	p90RSK	HUMAN|HGNC=10430|UniProtKB=Q15418	Ribosomal protein S6 kinase alpha-1	ISS	2779569	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00049	Parkinson disease	P01226	CDCrel-1	HUMAN|HGNC=9165|UniProtKB=O43236	Septin-4	IDA			PTHR18884:SF71	SEPTIN-4
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	CANLF|Gene=DRD2|UniProtKB=Q9GJU1	D(2) dopamine receptor	ISS	11248120	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00056	VEGF signaling pathway	P01417	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MACMU|Gene=C5AR1|UniProtKB=P79188	C5a anaphylatoxin chemotactic receptor 1 (Fragment)	ISS	6680818	gi	PTHR24225:SF29	C5A ANAPHYLATOXIN CHEMOTACTIC RECEPTOR 1
P00021	FGF signaling pathway	P00624	14-3-3	RAT|RGD=62002|UniProtKB=P61983	14-3-3 protein gamma	ISS	10407019	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	CAEBR|Gene=CBG18256|UniProtKB=A8XS95	Protein CBR-ACT-5	ISS	11889126	PubMed	PTHR11937:SF352	ACTIN
P04393	Ras Pathway	P04559	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	HUMAN|HGNC=7576|UniProtKB=P13533	Myosin-6	ISS	10938134	PubMed	PTHR13140:SF721	MYOSIN-6
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00018	EGF receptor signaling pathway	P00551	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00049	Parkinson disease	P01230	Src kinase	MOUSE|MGI=MGI=96052|UniProtKB=P08103	Tyrosine-protein kinase HCK	IDA	11078745	PubMed	PTHR24418:SF245	TYROSINE-PROTEIN KINASE HCK
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00059	p53 pathway	P04612	HDAC1	MOUSE|MGI=MGI=3704479|UniProtKB=D3YYI8	Histone deacetylase	IDA	10485845	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00890	ELK	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	ISS	11279280	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-478663|UniProtKB=F7EG64	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	IC	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05913	Enkephalin release	P05972	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00754	PDEgamma	CHICK|Ensembl=ENSGALG00000004514|UniProtKB=Q802E4	Phosphodiesterase 6 gamma subunit rod form	ISS			PTHR12122:SF4	RETINAL ROD RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT GAMMA
P02750	Lipoate_biosynthesis	P03004	Lipoate synthase	SULSO|EnsemblGenome=SSO3158|UniProtKB=Q97U63	Probable lipoyl synthase	ISS			PTHR10949:SF0	LIPOYL SYNTHASE, MITOCHONDRIAL
P00057	Wnt signaling pathway	P01455	Smad4	PANTR|Ensembl=ENSPTRG00000016485|UniProtKB=H2QQ88	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P00021	FGF signaling pathway	P00627	ERK1-2	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MOUSE|MGI=MGI=894644|UniProtKB=Q8CC27	Voltage-dependent L-type calcium channel subunit beta-2	IC	20088160	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P04395	Vasopressin synthesis	P04597	Signal Peptide	MACMU|Ensembl=ENSMMUG00000010678|UniProtKB=F7AXI7	Uncharacterized protein	ISS	3768139	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	9860142	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	RCA			PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00029	Huntington disease	P00807	Actin	CAEEL|WormBase=WBGene00000064|UniProtKB=P10984	Actin-2	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00005	Angiogenesis	P00219	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00017	DNA replication	P00527	Histones	PANTR|Ensembl=ENSPTRG00000017860|UniProtKB=H2QSJ2	Histone H3	ISS	12413958	PubMed	PTHR11426:SF175	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00907	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00020	FAS signaling pathway	P00611	Gelsolin	CHICK|Gene=GSN|UniProtKB=O93510	Gelsolin	IGI	9323209	PubMed	PTHR11977:SF29	GELSOLIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00828	Galphai	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	RCA			PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05913	Enkephalin release	P05974	G-Protein (i)	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	IC	10704417	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00029	Huntington disease	P00805	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	11591316	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04393	Ras Pathway	P04565	MKK4/7	PANTR|Ensembl=ENSPTRG00000008783|UniProtKB=H2QCA7	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00034	Integrin signalling pathway	P00944	Actin	MACMU|Ensembl=ENSMMUG00000001353|UniProtKB=F7D6T8	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CANLF|Ensembl=ENSCAFG00000029786|UniProtKB=Q9BDQ4	B2 bradykinin receptor	IDA	12130679	PubMed	PTHR24228:SF25	B2 BRADYKININ RECEPTOR
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=12783|UniProtKB=P56705	Protein Wnt-4	IDA	11266476	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00009	Axon guidance mediated by netrin	P00363	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	9516481	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	MOUSE|MGI=MGI=1916603|UniProtKB=Q9D2A5	Cyclic AMP-responsive element-binding protein 3-like protein 4	ISS	1354612	PubMed	PTHR22952:SF105	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 4
P00011	Blood coagulation	P00447	FVIIa	DANRE|ZFIN=ZDB-GENE-010814-1|UniProtKB=F1QFP3	Uncharacterized protein	ISS	18858363	gi	PTHR44064:SF1	COAGULATION FACTOR VII
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	ORYSJ|EnsemblGenome=OS03G0105600|UniProtKB=Q8H7U1	Tubulin beta-2 chain	ISS	12932731	PubMed	PTHR11588:SF178	TUBULIN BETA-7 CHAIN
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8971|UniProtKB=O00443	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00015	Circadian clock system	P00504	Per	MOUSE|MGI=MGI=1098283|UniProtKB=O35973	Period circadian protein homolog 1	IDA	12782655	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	STRPU|Gene=CYIIIB|UniProtKB=P18499	Actin, cytoskeletal 3B	IC	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P04376	5HT4 type receptor mediated signaling pathway	P04427	5HT4 Receptor	CHICK|Ensembl=ENSGALG00000001383|UniProtKB=F1NJL4	Uncharacterized protein	ISS	12898568	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P00052	TGF-beta signaling pathway	P01286	TGFbeta	PANTR|Ensembl=ENSPTRG00000002474|UniProtKB=H2Q1V5	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF157	GROWTH/DIFFERENTIATION FACTOR 2
P00005	Angiogenesis	P00184	Src	XENTR|Xenbase=XB-GENE-489820|UniProtKB=F7DXH6	Tyrosine-protein kinase	ISS	8054685	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00059	p53 pathway	P04631	P21	MOUSE|MGI=MGI=104556|UniProtKB=P39689	Cyclin-dependent kinase inhibitor 1	IGI	7774811	PubMed	PTHR10265:SF16	CYCLIN-DEPENDENT KINASE INHIBITOR 1
P00021	FGF signaling pathway	P00629	PP2A	BOVIN|Ensembl=ENSBTAG00000009245|UniProtKB=Q0P594	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	RAT|RGD=1304556|UniProtKB=P63259	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00034	Integrin signalling pathway	P00942	Fyn	HUMAN|HGNC=4037|UniProtKB=P06241	Tyrosine-protein kinase Fyn	IPI	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	RCA	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00034	Integrin signalling pathway	P00911	B-Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00223	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01439	C-terminal Binding Protein	PANTR|Ensembl=ENSPTRG00000015827|UniProtKB=H2RAD3	Uncharacterized protein	ISS	10375506	PubMed	PTHR10996:SF128	C-TERMINAL-BINDING PROTEIN 1
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	BOVIN|Ensembl=ENSBTAG00000011723|UniProtKB=E1BKL6	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00034	Integrin signalling pathway	P00941	Integrin alpha	MOUSE|MGI=MGI=104756|UniProtKB=B8JK39	Integrin alpha-9	IPI	10209034	PubMed	PTHR23220:SF69	INTEGRIN ALPHA-9
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000009085|UniProtKB=H2RDQ2	Uncharacterized protein	ISS	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IDA	2372396	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P05916	Opioid prodynorphin pathway	P06002	G-protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	ISS	10704417	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00057	Wnt signaling pathway	P01457	GBeta	DICDI|dictyBase=DDB_G0277143|UniProtKB=P36408	Guanine nucleotide-binding protein subunit beta	IDA	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00019	Endothelin signaling pathway	P00591	PLCbeta	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00005	Angiogenesis	P00203	Erk	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00648	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	7925653	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00551	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00907	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00238	Ras	DROME|FlyBase=FBgn0003205|UniProtKB=P08646	Ras-like protein 1	ISS			PTHR24070:SF385	GTPASE HRAS
P02738	De novo purine biosynthesis	P02901	Adenosuccinate lyase	SULSO|EnsemblGenome=SSO0240|UniProtKB=Q980P8	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00057	Wnt signaling pathway	P01458	Protein Kinase C	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	IDA	3755548	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00018	EGF receptor signaling pathway	P00562	p38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IGI	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00029	Huntington disease	P00777	CBP	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	DEIRA|EnsemblGenome=DR_2117|UniProtKB=Q9RSK7	Adenylate kinase	ISS			PTHR23359:SF22	GTP:AMP PHOSPHOTRANSFERASE, MITOCHONDRIAL
P04398	p53 pathway feedback loops 2	P04651	Ras	DANRE|ZFIN=ZDB-GENE-040808-67|UniProtKB=Q6AZA4	K-ras	ISS	10825661	PubMed	PTHR24070:SF186	GTPASE KRAS
P00049	Parkinson disease	P01236	Casein kinase II	MACMU|Ensembl=ENSMMUG00000015892|UniProtKB=F7BVK0	Uncharacterized protein	ISS	10617630	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	MACMU|Ensembl=ENSMMUG00000023256|UniProtKB=F7HPX5	Uncharacterized protein	ISS	11266476	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00021	FGF signaling pathway	P00627	ERK1-2	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00565	PKC	YEAST|SGD=S000000201|UniProtKB=P24583	Protein kinase C-like 1	IGI	90322419	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00021	FGF signaling pathway	P00623	FGF	BOVIN|Ensembl=ENSBTAG00000004013|UniProtKB=E1BEB9	Fibroblast growth factor	ISS	10819782	PubMed	PTHR11486:SF20	FIBROBLAST GROWTH FACTOR 7
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IDA	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05943	GRK2	BOVIN|Gene=ADRBK1|UniProtKB=P21146	Beta-adrenergic receptor kinase 1	RCA	8288567	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P04397	p53 pathway by glucose deprivation	P04641	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00013	Cell cycle	P00480	Proteasome	MACMU|Ensembl=ENSMMUG00000011125|UniProtKB=F6TS39	26S proteasome non-ATPase regulatory subunit 7	ISS	95275316	PubMed	PTHR10540:SF7	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7
P00053	T cell activation	P01312	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02771	Pyrimidine Metabolism	P03128	Dihydrouracil Dehydrogenase	PANTR|Ensembl=ENSPTRG00000000990|UniProtKB=H2PZG2	Dihydropyrimidine dehydrogenase	ISS	8912928	PubMed	PTHR43073:SF2	DIHYDROPYRIMIDINE DEHYDROGENASE  NADP +
P00018	EGF receptor signaling pathway	P00545	JNK1-3	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IGI	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IPI	10669416	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00019	Endothelin signaling pathway	P00570	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00012	Cadherin signaling pathway	P00471	Cadherin	DANRE|ZFIN=ZDB-GENE-990415-171|UniProtKB=Q90275	Cadherin-2	IDA	8120095	PubMed	PTHR24027:SF79	CADHERIN-2
P00045	Notch signaling pathway	P01112	CoR	MACMU|Ensembl=ENSMMUG00000023107|UniProtKB=F7GMR8	Uncharacterized protein	ISS	11112321	PubMed	PTHR13992:SF21	NUCLEAR RECEPTOR COREPRESSOR 2
P00059	p53 pathway	G04696	Siah	MOUSE|MGI=MGI=108063|UniProtKB=Q06985	E3 ubiquitin-protein ligase SIAH1B	IDA	11389839	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000017374|UniProtKB=F7H6T7	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MOUSE|MGI=MGI=108571|UniProtKB=Q9EQD0	Frizzled-5	TAS	8717036	PubMed	PTHR11309:SF126	FRIZZLED-5
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MONDO|Ensembl=ENSMODG00000004360|UniProtKB=F7FAW0	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF335	MYOSIN-11
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	CAEEL|WormBase=WBGene00013709|UniProtKB=Q8WQ99	Casein kinase I gamma	IDA	11437445	PubMed	PTHR11909:SF155	GILGAMESH, ISOFORM L
P00020	FAS signaling pathway	P00618	CAD	MOUSE|MGI=MGI=1196287|UniProtKB=O54788	DNA fragmentation factor subunit beta	TAS	10739646	PubMed	PTHR13067:SF2	DNAATION FACTOR-RELATED PROTEIN 4
P00048	PI3 kinase pathway	P01188	Gbetagamma	CANLF|Ensembl=ENSCAFG00000015662|UniProtKB=E2RHY4	Uncharacterized protein	ISS	10051575	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CANLF|Gene=GRIN1|UniProtKB=Q5R1P0	Glutamate receptor ionotropic, NMDA 1	IC	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00029	Huntington disease	P00775	Rac	PANTR|Ensembl=ENSPTRG00000028742|UniProtKB=H2R5M6	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF158	RHO-RELATED GTP-BINDING PROTEIN RHOG
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MONDO|Ensembl=ENSMODG00000013079|UniProtKB=F7FB74	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	MOUSE|MGI=MGI=1931052|UniProtKB=A6ZI47	Fructose-bisphosphate aldolase	ISS	6086339	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00052	TGF-beta signaling pathway	P01284	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00018	EGF receptor signaling pathway	P00551	Akt	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	IGI	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00965	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IC	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00547	PP2A	CHICK|Ensembl=ENSGALG00000010273|UniProtKB=P48463	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	IGI	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000021900|UniProtKB=F1MFK1	Uncharacterized protein	ISS	10644715	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00019	Endothelin signaling pathway	P00586	Gq	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	8838318	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P05918	p38 MAPK pathway	P05919	MAPKAP-K3	RAT|RGD=1304980|UniProtKB=Q66H84	MAP kinase-activated protein kinase 3	ISS	11335727	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00948	Rho	CHICK|Ensembl=ENSGALG00000003806|UniProtKB=O93467	GTP-binding protein	ISS	12169092	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00060	Ubiquitin proteasome pathway	P01491	E2	RAT|RGD=69425|UniProtKB=P70711	Ubiquitin-conjugating enzyme E2 D2B	ISS			PTHR24068:SF44	UBIQUITIN-CONJUGATING ENZYME E2 D2B
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	MOUSE|MGI=MGI=94925|UniProtKB=P30728	D(3) dopamine receptor	ISS	11248120	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00048	PI3 kinase pathway	P01196	PDK1	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	IDA	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00056	VEGF signaling pathway	P01408	Akt/PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01065	VAChT	RAT|RGD=62072|UniProtKB=Q62666	Vesicular acetylcholine transporter	IC			PTHR23506:SF13	VESICULAR ACETYLCHOLINE TRANSPORTER
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DICDI|dictyBase=DDB_G0283903|UniProtKB=Q54QB1	Extracellular signal-regulated kinase 2	IDA	10514528	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00912	Arp2/3	CHICK|Ensembl=ENSGALG00000003820|UniProtKB=E1C8Y3	Actin-related protein 2/3 complex subunit 3	ISS	9359840	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P05917	Opioid proopiomelanocortin pathway	P06004	Mu or Delta receptor	RAT|RGD=3234|UniProtKB=P33535	Mu-type opioid receptor	RCA	11259498	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P02743	Formyltetrahydroformate biosynthesis	P02952	Methylene tetrahydrofolate dehydrogenase	ARATH|TAIR=AT4G00600|UniProtKB=O65269	Bifunctional protein FolD 3, chloroplastic	ISS			PTHR10025:SF46	BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, MITOCHONDRIAL
P00005	Angiogenesis	P00238	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ORYSJ|EnsemblGenome=OS05G0438800|UniProtKB=Q75HX0	Actin	IDA	11889126	PubMed	PTHR11937:SF248	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IGI	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00006	Apoptosis signaling pathway	P00302	ATF	MACMU|Ensembl=ENSMMUG00000012185|UniProtKB=F7GUS9	Cyclic AMP-dependent transcription factor ATF-3 isoform 1	ISS	11390664	PubMed	PTHR23351:SF23	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-3
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	IC	10553940	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00029	Huntington disease	P00790	beta-Tubulin	SCLS1|EnsemblGenome=SS1G_04652|UniProtKB=A7EH60	Beta tubulin	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=7606|UniProtKB=Q13402	Unconventional myosin-VIIa	IC			PTHR13140:SF369	UNCONVENTIONAL MYOSIN-VIIA
P00047	PDGF signaling pathway	P01142	p90RSK	ORNAN|Ensembl=ENSOANG00000002226|UniProtKB=F6TPX7	Ribosomal protein S6 kinase	ISS	15116068	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MACMU|Ensembl=ENSMMUG00000004886|UniProtKB=F7AGT9	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	RAT|RGD=621516|UniProtKB=G3V6P8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P02775	Salvage pyrimidine ribonucleotides	P03149	Cytidine kinase	DEIRA|EnsemblGenome=DR_0159|UniProtKB=Q9RXZ5	Uridine kinase	ISS			PTHR10285:SF6	ATP-DEPENDENT KINASE TDA10-RELATED
P04393	Ras Pathway	P04570	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00777	CBP	ARATH|TAIR=AT3G12980|UniProtKB=Q9LE42	Histone acetyltransferase HAC5	IDA	10664585	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000006289|UniProtKB=H2Q875	Uncharacterized protein	ISS	12181435	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	HUMAN|HGNC=6267|UniProtKB=P48051	G protein-activated inward rectifier potassium channel 2	IDA			PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P05913	Enkephalin release	P05974	G-Protein (i)	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00005	Angiogenesis	P00188	Ets	MONDO|Ensembl=ENSMODG00000004730|UniProtKB=F6Y1Z2	Uncharacterized protein	ISS	9157999	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	7492337	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	IXOSC|EnsemblGenome=ISCW009711|UniProtKB=B7Q3T6	THO complex subunit, putative	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00019	Endothelin signaling pathway	P00566	ERK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	NAS	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04393	Ras Pathway	P04543	MEKK1/4	RAT|RGD=620966|UniProtKB=Q62925	Mitogen-activated protein kinase kinase kinase 1	IDA	8940199	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P06587	Nicotine pharmacodynamics pathway	P06608	DDC	MOUSE|MGI=MGI=94876|UniProtKB=O88533	Aromatic-L-amino-acid decarboxylase	TAS	107930	OMIM	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00029	Huntington disease	P00774	Dynein complex	BOVIN|Ensembl=ENSBTAG00000024605|UniProtKB=P61285	Dynein light chain 1, cytoplasmic	ISS	9454836	PubMed	PTHR11886:SF52	DYNEIN LIGHT CHAIN 1, CYTOPLASMIC
P00005	Angiogenesis	P00238	Ras	DICDI|dictyBase=DDB_G0281385|UniProtKB=P32253	Ras-like protein rasC	ISS			PTHR24070:SF251	RAS-LIKE PROTEIN RASC
P00053	T cell activation	P01322	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04630	PP2A	DANRE|ZFIN=ZDB-GENE-040426-877|UniProtKB=F1Q6Z7	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00059	p53 pathway	P04633	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05755	Gbeta	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00552	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IGI	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00034	Integrin signalling pathway	P00920	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	IPI	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P02734	Chorismate biosynthesis	P02868	Chorismate synthase	LEPIN|EnsemblGenome=LA_0157|UniProtKB=Q8F9N4	Chorismate synthase	ISS			PTHR21085:SF0	CHORISMATE SYNTHASE
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	CAEBR|Gene=CBG06199|UniProtKB=A8X0P1	Glutamate dehydrogenase	ISS			PTHR11606:SF13	GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL
P00004	Alzheimer disease-presenilin pathway	P00113	Erb-B4 transmembrane fragment	MOUSE|MGI=MGI=104771|UniProtKB=Q61527	Receptor tyrosine-protein kinase erbB-4	ISS	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	TAS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	BOVIN|Ensembl=ENSBTAG00000011579|UniProtKB=F1N5C5	Muscarinic acetylcholine receptor	ISS	12915051	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00019	Endothelin signaling pathway	P00589	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IGI	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05731	GABA-B receptor II signaling	P05754	Ggamma	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00010	B cell activation	P00391	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00034	Integrin signalling pathway	P00944	Actin	MONDO|Ensembl=ENSMODG00000012036|UniProtKB=F7ALP1	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04393	Ras Pathway	P04542	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01175	Shc	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	ISS	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00254	GTPase	YARLI|EnsemblGenome=YALI0_E23001g|UniProtKB=Q6C4X3	YALI0E23001p	ISS			PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12805548	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P02757	O-antigen biosynthesis	P03050	dTDP-4-dehydrorhamnose reductase	LEPIN|EnsemblGenome=LA_1660|UniProtKB=Q8F5L8	dTDP-4-dehydrorhamnose reductase	ISS			PTHR10491:SF4	METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA
P00036	Interleukin signaling pathway	P00996	STAT	CHICK|Ensembl=ENSGALG00000003267|UniProtKB=Q6DV79	Signal transducer and activator of transcription 3	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	HUMAN|HGNC=19663|UniProtKB=Q9UBI6	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00005	Angiogenesis	P00251	cPLA2	MONDO|Ensembl=ENSMODG00000011791|UniProtKB=F7CBU9	Phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00053	T cell activation	P01332	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IDA	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	BOVIN|Ensembl=ENSBTAG00000039151|UniProtKB=F6R5F6	Uncharacterized protein	ISS			PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00036	Interleukin signaling pathway	P00996	STAT	CHICK|Ensembl=ENSGALG00000003267|UniProtKB=Q6DV79	Signal transducer and activator of transcription 3	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	STRCO|EnsemblGenome=CAB52840|UniProtKB=Q9S224	CTP synthase	ISS			PTHR11550:SF0	CTP SYNTHASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	CAEBR|Gene=CBG01097|UniProtKB=A8WPJ8	Protein CBR-CMD-1	ISS	10487978	PubMed	PTHR23050:SF236	CALMODULIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	RCA	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00034	Integrin signalling pathway	P00936	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01438	PP2A	RAT|RGD=3380|UniProtKB=P63331	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	IDA	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01432	Beta-Catenin	MONDO|Ensembl=ENSMODG00000011192|UniProtKB=F6SRK5	Uncharacterized protein	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P02738	De novo purine biosynthesis	P02907	dADP kinase	DICDI|dictyBase=DDB_G0279911|UniProtKB=P34093	Nucleoside diphosphate kinase, mitochondrial	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00049	Parkinson disease	P01208	Hsp70	ANOGA|EnsemblGenome=AGAP004581|UniProtKB=A7UT42	AGAP004581-PA	IDA	12150907	PubMed	PTHR19375:SF256	HSP70 PROTEIN-RELATED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	HUMAN|HGNC=1953|UniProtKB=P08173	Muscarinic acetylcholine receptor M4	ISS	11166329	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	CAEEL|WormBase=WBGene00002173|UniProtKB=Q9Y0A1	Inositol 1,4,5-trisphosphate receptor itr-1	ISS	1849282	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00005	Angiogenesis	P00213	FGF	MONDO|Ensembl=ENSMODG00000018899|UniProtKB=P48798	Fibroblast growth factor 2	ISS			PTHR11486:SF83	FIBROBLAST GROWTH FACTOR 2
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	NEUCR|EnsemblGenome=EFNCRG00000002934|UniProtKB=Q8TG13	Casein kinase II subunit alpha	IDA	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	DROME|FlyBase=FBgn0026439|UniProtKB=O77062	Excitatory amino acid transporter 1, isoform A	ISS	96032356	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IGI	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00053	T cell activation	P01306	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P06959	CCKR signaling map	P07227	KLF4	HUMAN|HGNC=6348|UniProtKB=O43474	Krueppel-like factor 4	RCA		PubMed	PTHR44778:SF1	KRUEPPEL-LIKE FACTOR 4
P00004	Alzheimer disease-presenilin pathway	P00139	E-cadherin transmembrane fragment	MOUSE|MGI=MGI=88356|UniProtKB=P10287	Cadherin-3	IDA	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P00006	Apoptosis signaling pathway	P00303	c-Jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00018	EGF receptor signaling pathway	P00552	Ras	DICPU|Gene=DICPUDRAFT_92731|UniProtKB=F0ZWE6	Putative uncharacterized protein rasG	ISS	7997267	PubMed	PTHR24070:SF282	RAS GTPASE-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00053	T cell activation	P01300	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	HUMAN|HGNC=30587|UniProtKB=Q8TAD8	Smad nuclear-interacting protein 1	IGI	10400677	PubMed	PTHR23308:SF36	SMAD NUCLEAR-INTERACTING PROTEIN 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05918	p38 MAPK pathway	P05921	MKP5	MACMU|Ensembl=ENSMMUG00000004379|UniProtKB=F7FRM2	Dual specificity protein phosphatase 10 isoform a	ISS	11856337	PubMed	PTHR10159:SF299	DUAL SPECIFICITY PROTEIN PHOSPHATASE 10
P00006	Apoptosis signaling pathway	P00310	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02746	Heme biosynthesis	P02975	Uroporphyrinogen decarboxylase	SCHPO|PomBase=SPCC4B3.05c|UniProtKB=Q9USJ5	Uroporphyrinogen decarboxylase	ISS			PTHR21091:SF2	UROPORPHYRINOGEN DECARBOXYLASE
P00021	FGF signaling pathway	P00629	PP2A	MOUSE|MGI=MGI=1349475|UniProtKB=Q60996	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	ISS	10092233	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01212	p38 MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04397	p53 pathway by glucose deprivation	P04641	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00029	Huntington disease	P00778	NMDA receptor	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00047	PDGF signaling pathway	P01161	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=619917|UniProtKB=F1MA46	Protein Pcdh12	ISS	8120095	PubMed	PTHR24028:SF42	PROTOCADHERIN-12
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	G01550	Gene trancription	HUMAN|HGNC=5434|UniProtKB=P01574	Interferon beta	ISS			PTHR11691:SF43	INTERFERON BETA
P00054	Toll receptor signaling pathway	P01346	TLR	PANTR|Ensembl=ENSPTRG00000016658|UniProtKB=B3Y620	Toll-like receptor 3	ISS			PTHR44599:SF1	TOLL-LIKE RECEPTOR 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=3023|UniProtKB=P14416	D(2) dopamine receptor	IDA	2039532	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IGI	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00059	p53 pathway	P01485	p53	CANLF|Gene=TP53|UniProtKB=Q29537	Cellular tumor antigen p53	TAS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00053	T cell activation	P01294	NFAT	HUMAN|HGNC=7778|UniProtKB=Q14934	Nuclear factor of activated T-cells, cytoplasmic 4	IGI	12015605	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00057	Wnt signaling pathway	P01457	GBeta	IXOSC|EnsemblGenome=ISCW009711|UniProtKB=B7Q3T6	THO complex subunit, putative	ISS	9740024	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P02749	Leucine biosynthesis	P03000	Branched chain amino acid aminotransferase	METAC|EnsemblGenome=MA_4349|UniProtKB=Q8TI08	Branched chain amino acid aminotransferase	ISS			PTHR42743:SF3	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE-LIKE PROTEIN 1-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	RAT|RGD=67399|UniProtKB=Q64716	Insulin receptor-related protein	ISS	12644000	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00007	Axon guidance mediated by semaphorins	P00341	Rho	CHICK|Ensembl=ENSGALG00000003806|UniProtKB=O93467	GTP-binding protein	ISS	12039949	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	IC	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00913	Csk	MOUSE|MGI=MGI=88537|UniProtKB=P41241	Tyrosine-protein kinase CSK	IDA	12665526	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	CAEEL|WormBase=WBGene00000366|UniProtKB=P34545	Protein cbp-1	IDA			PTHR13808:SF1	NEJIRE, ISOFORM C
P00036	Interleukin signaling pathway	P00977	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IC	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00005	Angiogenesis	P00243	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00924	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00011	Blood coagulation	P00428	alpha2-antiplasmin	MACMU|Ensembl=ENSMMUG00000002382|UniProtKB=F7BTD3	Uncharacterized protein	ISS	11386143	gi	PTHR11461:SF20	ALPHA-2-ANTIPLASMIN
P00010	B cell activation	P00375	Calmodulin	BOVIN|Ensembl=ENSBTAG00000001575|UniProtKB=F1N6C0	Uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF311	CALMODULIN
P00005	Angiogenesis	P00223	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00927	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MACMU|Ensembl=ENSMMUG00000019112|UniProtKB=F6T8S6	N-methyl D-aspartate receptor subtype 2B	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00029	Huntington disease	P00775	Rac	DICDI|dictyBase=DDB_G0277869|UniProtKB=P34144	Rho-related protein rac1A	TAS			PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00029	Huntington disease	P00777	CBP	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P02741	Flavin biosynthesis	P02939	Lumazine synthase	CHLTR|EnsemblGenome=CT_732|UniProtKB=O84737	6,7-dimethyl-8-ribityllumazine synthase	ISS			PTHR21058:SF0	6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	PANTR|Ensembl=ENSPTRG00000004718|UniProtKB=H2Q5I0	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	DEIRA|EnsemblGenome=DR_1207|UniProtKB=Q9RV23	tRNA(Ile)-lysidine synthase	ISS			PTHR43033:SF1	TRNA ILE -LYSIDINE SYNTHASE
P00004	Alzheimer disease-presenilin pathway	P00110	Ire-1 N-terminal fragment	PANTR|Ensembl=ENSPTRG00000007893|UniProtKB=H2QAS4	Uncharacterized protein	ISS	10619423	PubMed	PTHR13954:SF15	SERINE/THREONINE-PROTEIN KINASE/ENDORIBONUCLEASE IRE2
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	P01465	Ggamma	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	9298898	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	MONDO|Ensembl=ENSMODG00000013970|UniProtKB=F6R6X5	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00571	Pro ET1-4	HUMAN|HGNC=3176|UniProtKB=P05305	Endothelin-1	ISS	15117818	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00030	Hypoxia response via HIF activation	P00817	TOR	PANTR|Ensembl=ENSPTRG00000000142|UniProtKB=H2PY03	Uncharacterized protein	ISS	14526383	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00010	B cell activation	P00402	Jnk	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00023	General transcription regulation	P00666	TFIIE	CAEEL|WormBase=WBGene00010054|UniProtKB=G5EG47	Transcription initiation factor IIE subunit beta	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P00048	PI3 kinase pathway	P01179	PKB	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DANRE|ZFIN=ZDB-GENE-000322-1|UniProtKB=Q9I8V1	Actin, alpha 1, skeletal muscle	IC	11889126	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00010	B cell activation	P00371	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02787	Vitamin B6 metabolism	P03236	Pyridoxamine phosphate oxidase	MACMU|Ensembl=ENSMMUG00000003325|UniProtKB=F7EHD9	Pyridoxine-5'-phosphate oxidase	ISS	14697241	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00056	VEGF signaling pathway	P01414	PLC-gamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00021	FGF signaling pathway	P00644	p38	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	IGI	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00005	Angiogenesis	P00227	PLA2	PANTR|Ensembl=ENSPTRG00000001787|UniProtKB=H2Q0T0	Phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00206	Wnt	MACMU|Ensembl=ENSMMUG00000017345|UniProtKB=F7H9C0	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01080	AChE	PANTR|Ensembl=ENSPTRG00000019514|UniProtKB=H2R3Y8	Carboxylic ester hydrolase	ISS	86008285	PubMed	PTHR11559:SF356	ACETYLCHOLINESTERASE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00036	Interleukin signaling pathway	P00995	c-Myc	HUMAN|HGNC=7553|UniProtKB=P01106	Myc proto-oncogene protein	ISS	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00018	EGF receptor signaling pathway	P00552	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00034	Integrin signalling pathway	P00927	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MOUSE|MGI=MGI=104589|UniProtKB=P63268	Actin, gamma-enteric smooth muscle	IC	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00053	T cell activation	P01336	Jnk	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IGI	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	BOVIN|Ensembl=ENSBTAG00000011723|UniProtKB=E1BKL6	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00055	Transcription regulation by bZIP transcription factor	P01392	TFIIH complex	PANTR|Ensembl=ENSPTRG00000003420|UniProtKB=H2Q394	General transcription factor IIH, polypeptide 1, 62kDa	ISS			PTHR12856:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	CANLF|Gene=MYH1|UniProtKB=Q076A6	Myosin-1	ISS	10938134	PubMed	PTHR13140:SF484	MYOSIN-1
P05731	GABA-B receptor II signaling	P05755	Gbeta	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00020	FAS signaling pathway	P00618	CAD	HUMAN|HGNC=2773|UniProtKB=O76075	DNA fragmentation factor subunit beta	TAS	10739646	PubMed	PTHR13067:SF2	DNAATION FACTOR-RELATED PROTEIN 4
P05730	Endogenous cannabinoid signaling	P05746	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MOUSE|MGI=MGI=1309999|UniProtKB=Q922R0	cAMP-dependent protein kinase catalytic subunit PRKX	IC	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00030	Hypoxia response via HIF activation	P00823	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00559	MEK1-2	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IGI	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	15572354	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MOUSE|MGI=MGI=107814|UniProtKB=A2AQ07	Tubulin beta-1 chain	ISS	9454836	PubMed	PTHR11588:SF112	TUBULIN BETA-1 CHAIN
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01155	Jak	RAT|RGD=2939|UniProtKB=Q62689	Tyrosine-protein kinase JAK2	ISS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00018	EGF receptor signaling pathway	P00557	PI3K	SCHPO|PomBase=SPAC458.05|UniProtKB=P50520	Phosphatidylinositol 3-kinase vps34	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00047	PDGF signaling pathway	P01147	Nck	BOVIN|Ensembl=ENSBTAG00000018427|UniProtKB=Q1LZB2	NCK adaptor protein 1	ISS	12874226	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P00010	B cell activation	P00402	Jnk	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00547	PP2A	MACMU|Ensembl=ENSMMUG00000019771|UniProtKB=F7APV7	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform 1	ISS	12110603	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00056	VEGF signaling pathway	P01408	Akt/PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00047	PDGF signaling pathway	P01143	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00019	Endothelin signaling pathway	P00577	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00811	Arp2/3 complex	BOVIN|Ensembl=ENSBTAG00000015278|UniProtKB=Q5E963	Actin-related protein 2/3 complex subunit 5-like protein	ISS	12932731	PubMed	PTHR12644:SF2	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5-LIKE PROTEIN
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00021	FGF signaling pathway	P00648	PKC	SCHPO|PomBase=SPBC12D12.04c|UniProtKB=P36583	Protein kinase C-like 2	IGI	93259141	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MACMU|Ensembl=ENSMMUG00000016751|UniProtKB=F7AIB6	Mitogen-activated protein kinase kinase kinase 3 isoform 1	ISS	9006902	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00034	Integrin signalling pathway	P00910	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12186904	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00052	TGF-beta signaling pathway	P01286	TGFbeta	BOVIN|Ensembl=ENSBTAG00000009478|UniProtKB=Q9GK68	Growth/differentiation factor 9	TAS	9759503	PubMed	PTHR11848:SF19	GROWTH/DIFFERENTIATION FACTOR 9
P00046	Oxidative stress response	P01135	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	TAS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	IC	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	HUMAN|HGNC=5289|UniProtKB=P28221	5-hydroxytryptamine receptor 1D	IDA			PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00021	FGF signaling pathway	P00627	ERK1-2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01143	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	12657601	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	RAT|RGD=71012|UniProtKB=Q08464	Frizzled-2	TAS	11212302	PubMed	PTHR11309:SF34	FRIZZLED-2
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04393	Ras Pathway	P04552	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P06959	CCKR signaling map	G06995	NR4A1	HUMAN|HGNC=7980|UniProtKB=P22736	Nuclear receptor subfamily 4 group A member 1	RCA	17962809	PubMed	PTHR24085:SF1	NUCLEAR RECEPTOR SUBFAMILY 4 GROUP A MEMBER 1
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IDA	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	BOVIN|Ensembl=ENSBTAG00000039772|UniProtKB=F6QI78	Uncharacterized protein	ISS	12441358	PubMed	PTHR24247:SF31	5-HYDROXYTRYPTAMINE RECEPTOR 2B
P00029	Huntington disease	P00807	Actin	XENTR|GeneID=394982|UniProtKB=P20399	Actin, alpha cardiac muscle 2	ISS	11889126	PubMed	PTHR11937:SF263	ACTIN
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00925	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00779	TBP	HUMAN|HGNC=11588|UniProtKB=P20226	TATA-box-binding protein	ISS	600075	OMIM	PTHR10126:SF20	TATA-BOX-BINDING PROTEIN
P00057	Wnt signaling pathway	P01454	betaTrCP	MACMU|Ensembl=ENSMMUG00000016008|UniProtKB=F7FVG8	Uncharacterized protein	ISS	10074433	PubMed	PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00054	Toll receptor signaling pathway	P01346	TLR	DROME|FlyBase=FBgn0034476|UniProtKB=Q7KIN0	Toll-like receptor 7	ISS			PTHR44740:SF1	18 WHEELER-RELATED
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05916	Opioid prodynorphin pathway	P05999	provasopressin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	DROME|FlyBase=FBgn0260964|UniProtKB=Q8IH57	GH10249p	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00059	p53 pathway	G04694	p110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06709	FOS	MOUSE|MGI=MGI=95575|UniProtKB=P13346	Protein fosB	RCA			PTHR23351:SF3	PROTEIN FOSB
P00020	FAS signaling pathway	P00615	JNK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	TAS	10851062	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00034	Integrin signalling pathway	P00923	Arf1	ARATH|TAIR=AT1G10630|UniProtKB=Q6ID97	ADP-ribosylation factor A1F	ISS	11752622	PubMed	PTHR11711:SF210	ADP-RIBOSYLATION FACTOR 2-A-RELATED
P00019	Endothelin signaling pathway	P00572	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00560	Raf-1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00010	B cell activation	P00388	PLC gamma2	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00021	FGF signaling pathway	P00632	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IGI	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TRIVA|Gene=TVAG_512800|UniProtKB=A2HNG1	Actin (Fragment)	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00006	Apoptosis signaling pathway	P00321	HSP70	SCHPO|PomBase=SPAC13G7.02c|UniProtKB=Q10265	Probable heat shock protein ssa1	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00030	Hypoxia response via HIF activation	P00819	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	IGI	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00010	B cell activation	P00370	NFkappaB	BOVIN|Ensembl=ENSBTAG00000006017|UniProtKB=F6Q9X9	Uncharacterized protein	ISS	9133421	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00052	TGF-beta signaling pathway	P01286	TGFbeta	CAEEL|WormBase=WBGene00006852|UniProtKB=G5EBY8	UNC-129	TAS	9759503	PubMed	PTHR11848:SF4	UNC-129
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00845	Cyclooxygenase	HUMAN|HGNC=9605|UniProtKB=P35354	Prostaglandin G/H synthase 2	RCA			PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00003	Alzheimer disease-amyloid secretase pathway	P00094	BACE-1 pro-domain	HUMAN|HGNC=933|UniProtKB=P56817	Beta-secretase 1	IDA	10956649	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	CAEBR|Gene=CBG02059|UniProtKB=A8WRW6	Protein CBR-UNC-2 (Fragment)	ISS	8386525	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06856	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	RCA	4504111	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	RAT|RGD=2025|UniProtKB=P68136	Actin, alpha skeletal muscle	ISS	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	PANTR|Ensembl=ENSPTRG00000019361|UniProtKB=H2QUV3	Uncharacterized protein	ISS	20012997	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00006	Apoptosis signaling pathway	P00268	GCK	PANTR|Ensembl=ENSPTRG00000003847|UniProtKB=H2Q407	Mitogen-activated protein kinase kinase kinase kinase	ISS			PTHR24361:SF392	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 2
P00010	B cell activation	P00392	I kappa B	MOUSE|MGI=MGI=104741|UniProtKB=Q9Z1E3	NF-kappa-B inhibitor alpha	ISS	10811867	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00059	p53 pathway	P01486	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02770	Pyridoxal phosphate salvage pathway	P03122	Pyridoxamine kinase	ECOLI|EcoGene=EG13940|UniProtKB=P77150	Pyridoxal kinase PdxY	ISS	11677609	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P00054	Toll receptor signaling pathway	P01352	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00029	Huntington disease	P00805	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01227	20S proteasome	CAEEL|WormBase=WBGene00003922|UniProtKB=O17586	Proteasome subunit alpha type-6	TAS	12859888	PubMed	PTHR11599:SF11	PROTEASOME SUBUNIT ALPHA TYPE-6
P00056	VEGF signaling pathway	P01420	FAK	HUMAN|HGNC=9611|UniProtKB=Q05397	Focal adhesion kinase 1	IDA	12640026	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00020	FAS signaling pathway	P00601	c-Jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00029	Huntington disease	P00795	BDNF	CHICK|Ensembl=ENSGALG00000012163|UniProtKB=P25429	Brain-derived neurotrophic factor	TAS	12117585	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00057	Wnt signaling pathway	P01443	Phospholipase C	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	TAS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	IDA	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00274	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00010	B cell activation	P00384	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	ISS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IC	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00556	PLCgamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	DROME|FlyBase=FBgn0004921|UniProtKB=P38040	Guanine nucleotide-binding protein subunit gamma-1	IC	2122451	PubMed	PTHR13809:SF3	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA-RELATED
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=103077|UniProtKB=Q64704	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P04393	Ras Pathway	P04567	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00010	B cell activation	P00371	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IDA	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00005	Angiogenesis	P00221	JNK1	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00012	Cadherin signaling pathway	P00475	Frizzled	RAT|RGD=631406|UniProtKB=Q8CHL0	Frizzled-5	ISS	8717036	PubMed	PTHR11309:SF126	FRIZZLED-5
P00021	FGF signaling pathway	P00631	Grb2	CAEEL|WormBase=WBGene00004774|UniProtKB=P29355	Sex muscle abnormal protein 5	IPI	51702266	gi	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00047	PDGF signaling pathway	P01142	p90RSK	XENTR|Xenbase=XB-GENE-482409|UniProtKB=F6UK84	Uncharacterized protein (Fragment)	ISS	11861821	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	RAT|RGD=620436|UniProtKB=P11962	Glycoprotein hormones alpha chain	ISS	15927770	PubMed	PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00034	Integrin signalling pathway	P00948	Rho	MOUSE|MGI=MGI=2444878|UniProtKB=Q8BLR7	Rho-related GTP-binding protein Rho6	IGI	11973360	PubMed	PTHR24072:SF23	RHO-RELATED GTP-BINDING PROTEIN RHO6
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	PANTR|Ensembl=ENSPTRG00000000387|UniProtKB=H2PYE3	Ribosomal protein S6 kinase	ISS	12769834	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	ANOGA|EnsemblGenome=AGAP004613|UniProtKB=Q7Q7P1	AGAP004613-PA (Fragment)	ISS	11248120	PubMed	PTHR43893:SF6	DOPAMINE RECEPTOR 1
P05731	GABA-B receptor II signaling	P05755	Gbeta	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00049	Parkinson disease	P01211	ERK	ORYSJ|EnsemblGenome=OS06G0699400|UniProtKB=Q5Z859	Mitogen-activated protein kinase 4	IDA	9836510	gi	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	MACMU|Ensembl=ENSMMUG00000011442|UniProtKB=F7B9T3	Ras-related protein Rap-1b	ISS	10476970	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00004	Alzheimer disease-presenilin pathway	P00127	APP	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00057	Wnt signaling pathway	P01451	Galpha	RAT|RGD=619751|UniProtKB=O88302	Guanine nucleotide-binding protein subunit alpha-15	IDA	11534853	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00047	PDGF signaling pathway	P01173	STAT	CANLF|Ensembl=ENSCAFG00000015213|UniProtKB=E2RB82	Signal transducer and activator of transcription	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00036	Interleukin signaling pathway	P00981	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P06211	BMP/activin signaling pathway-drosophila	P06244	Furin	DROME|FlyBase=FBgn0004509|UniProtKB=P26016	Furin-like protease 1, isoforms 1/1-X/2	IEA	7737999	PubMed	PTHR42884:SF3	FURIN-LIKE PROTEASE 1, ISOFORMS 1/1-X/2
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	12707323	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00047	PDGF signaling pathway	P01173	STAT	CANLF|Ensembl=ENSCAFG00000015213|UniProtKB=E2RB82	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	MOUSE|MGI=MGI=99684|UniProtKB=A2AGL3	Ryanodine receptor 3	ISS	15858232	PubMed	PTHR13715:SF16	RYANODINE RECEPTOR 3
P00023	General transcription regulation	P00660	RNA Polymerase II	MOUSE|MGI=MGI=2384309|UniProtKB=Q923G2	DNA-directed RNA polymerases I, II, and III subunit RPABC3	ISS	606023	OMIM	PTHR10917:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CHICK|Ensembl=ENSGALG00000009405|UniProtKB=F1NKF1	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00009	Axon guidance mediated by netrin	P00360	DCC/UNC-40	MONDO|Ensembl=ENSMODG00000011028|UniProtKB=F7F4D5	Uncharacterized protein	ISS	8861902	PubMed	PTHR44146:SF3	NETRIN RECEPTOR DCC
P06959	CCKR signaling map	P07100	Dynamin	HUMAN|HGNC=2972|UniProtKB=Q05193	Dynamin-1	RCA	8995203	PubMed	PTHR11566:SF32	DYNAMIN-1
P00012	Cadherin signaling pathway	P00475	Frizzled	PANTR|Ensembl=ENSPTRG00000028542|UniProtKB=H2R591	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF79	FRIZZLED-9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ORYSJ|EnsemblGenome=OS10G0510000|UniProtKB=A3C6D7	Actin-2	IC	10974003	PubMed	PTHR11937:SF252	SUBFAMILY NOT NAMED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	CAEEL|WormBase=WBGene00021125|UniProtKB=A0A078BQJ0	Calcium Channel, Beta subunit	IC			PTHR11824:SF10	CALCIUM CHANNEL, BETA SUBUNIT
P00052	TGF-beta signaling pathway	P01275	P38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	TAS	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	XENTR|Xenbase=XB-GENE-966302|UniProtKB=F6T2E7	Uncharacterized protein	ISS	10644687	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00049	Parkinson disease	P01230	Src kinase	PANTR|Ensembl=ENSPTRG00000007282|UniProtKB=H2Q9T1	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000002297|UniProtKB=F1N167	Uncharacterized protein	ISS			PTHR11824:SF7	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4
P00029	Huntington disease	P00778	NMDA receptor	HUMAN|HGNC=4584|UniProtKB=Q05586	Glutamate receptor ionotropic, NMDA 1	IDA	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01438	PP2A	MACMU|Ensembl=ENSMMUG00000004873|UniProtKB=F7ANY9	Uncharacterized protein	ISS	12110603	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00005	Angiogenesis	P00238	Ras	DICPU|Gene=DICPUDRAFT_51488|UniProtKB=F1A411	Putative uncharacterized protein rasC	ISS			PTHR24070:SF251	RAS-LIKE PROTEIN RASC
P04392	P53 pathway feedback loops 1	P04539	p53	BOVIN|Ensembl=ENSBTAG00000005812|UniProtKB=G3X6J7	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P02770	Pyridoxal phosphate salvage pathway	P03123	Pyridoxine-5-phosphate oxidase	BOVIN|Ensembl=ENSBTAG00000012259|UniProtKB=Q5E9K3	Pyridoxine-5'-phosphate oxidase	ISS	14697241	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00029	Huntington disease	P00805	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01129	JNK1/2	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00010	B cell activation	P00378	SHP-1	MOUSE|MGI=MGI=96055|UniProtKB=P29351	Tyrosine-protein phosphatase non-receptor type 6	TAS	14525967	PubMed	PTHR19134:SF65	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 6
P04393	Ras Pathway	P04563	Ets	PANTR|Ensembl=ENSPTRG00000004466|UniProtKB=H2RCM3	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IDA	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00049	Parkinson disease	P01238	14-3-3	DAPPU|EnsemblGenome=DAPPUDRAFT_326737|UniProtKB=E9H8M4	Putative uncharacterized protein	ISS	97302963	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	IDA	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95809|UniProtKB=P23819	Glutamate receptor 2	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00589	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00638	PLCgamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04392	P53 pathway feedback loops 1	P04539	p53	HUMAN|HGNC=11998|UniProtKB=P04637	Cellular tumor antigen p53	TAS	11313951	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000007445|UniProtKB=F6SWI4	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	RAT|RGD=2532|UniProtKB=P22388	Endothelin-1	ISS	12773307	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CANLF|Gene=GRIN1|UniProtKB=Q5R1P0	Glutamate receptor ionotropic, NMDA 1	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00048	PI3 kinase pathway	P01179	PKB	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	TAS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	CHICK|Ensembl=ENSGALG00000008459|UniProtKB=F6RIN4	Receptor protein serine/threonine kinase	TAS	9395284	PubMed	PTHR23255:SF63	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-2
P05918	p38 MAPK pathway	P06020	p38delta	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00034	Integrin signalling pathway	P00917	ELMO	HUMAN|HGNC=16286|UniProtKB=Q92556	Engulfment and cell motility protein 1	IDA	12879077	PubMed	PTHR12771:SF23	ENGULFMENT AND CELL MOTILITY PROTEIN 1
P00021	FGF signaling pathway	P00641	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	IC	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BOVIN|Ensembl=ENSBTAG00000009217|UniProtKB=F1MEW8	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P06664	Gonadotropin-releasing hormone receptor pathway	P06768	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	RCA	12880387	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MACMU|Ensembl=ENSMMUG00000010392|UniProtKB=F7ASR8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	DROME|FlyBase=FBgn0260798|UniProtKB=P32865	G protein-coupled receptor kinase 1	IDA	8260489	PubMed	PTHR24355:SF18	PROTEIN-SERINE/THREONINE KINASE
P00056	VEGF signaling pathway	P01408	Akt/PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	MOUSE|MGI=MGI=1345146|UniProtKB=Q9WVL4	Rhodopsin kinase	ISS	8288567	PubMed	PTHR24355:SF11	RHODOPSIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00174	CD44 N-terminal fragment	PANTR|Ensembl=ENSPTRG00000003501|UniProtKB=H2Q3E8	Uncharacterized protein	ISS	12223485	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P00021	FGF signaling pathway	P00642	MEK1-2	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	94313981	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	HUMAN|HGNC=10939|UniProtKB=P43005	Excitatory amino acid transporter 3	ISS	96032356	PubMed	PTHR11958:SF69	EXCITATORY AMINO ACID TRANSPORTER 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00034	Integrin signalling pathway	P00925	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=4593|UniProtKB=Q13255	Metabotropic glutamate receptor 1	IDA			PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00036	Interleukin signaling pathway	P00997	Shc	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	IC	95096035	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	TAS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00055	Transcription regulation by bZIP transcription factor	P01398	TFIIEalpha	MOUSE|MGI=MGI=1921447|UniProtKB=Q9D0D5	General transcription factor IIE subunit 1	ISS	189964	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CANLF|Ensembl=ENSCAFG00000004381|UniProtKB=J9JH96	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	RAT|RGD=619879|UniProtKB=G3V816	Nucleoside diphosphate kinase	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00590	IP3 R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00052	TGF-beta signaling pathway	P01284	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P02755	Methylmalonyl pathway	P03033	Propionyl-CoA carboxylase	MOUSE|MGI=MGI=1914154|UniProtKB=Q99MN9	Propionyl-CoA carboxylase beta chain, mitochondrial	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P00029	Huntington disease	P00780	Microtubule	MOUSE|MGI=MGI=1920960|UniProtKB=Q9CWF2	Tubulin beta-2B chain	ISS	9454836	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00006	Apoptosis signaling pathway	P00277	Bi1	MONDO|Ensembl=ENSMODG00000004277|UniProtKB=F6TEK9	Uncharacterized protein	ISS			PTHR23291:SF34	BAX INHIBITOR 1
P05917	Opioid proopiomelanocortin pathway	P06010	proopiomelanocortin	MACMU|Ensembl=ENSMMUG00000016463|UniProtKB=F7GBI0	Uncharacterized protein	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00012	Cadherin signaling pathway	P00463	betacatenin	CANLF|Ensembl=ENSCAFG00000005204|UniProtKB=B6V8E6	Catenin beta-1	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00029	Huntington disease	P00797	p53	BOVIN|Ensembl=ENSBTAG00000001069|UniProtKB=P67939	Cellular tumor antigen p53	TAS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05961	DOPA decarb.	CAEBR|Gene=CBG08967|UniProtKB=A8X844	Protein CBR-BAS-1	ISS	90339966	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00034	Integrin signalling pathway	P00916	Ras	BOVIN|Ensembl=ENSBTAG00000009778|UniProtKB=E1BMX0	Uncharacterized protein	ISS	99084794	PubMed	PTHR24070:SF186	GTPASE KRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	CANLF|Ensembl=ENSCAFG00000003029|UniProtKB=P41324	Interleukin-8	ISS	124361	gi	PTHR10179:SF70	INTERLEUKIN-8
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00057	Wnt signaling pathway	P01447	Dishevelled	MACMU|Ensembl=ENSMMUG00000006553|UniProtKB=F7HRY3	Uncharacterized protein	ISS	10409711	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P00052	TGF-beta signaling pathway	P01284	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00046	Oxidative stress response	P01131	MKP5	RAT|RGD=1305804|UniProtKB=Q5M863	Dual specificity protein phosphatase	ISS			PTHR10159:SF109	DUAL SPECIFICITY PROTEIN PHOSPHATASE 2
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05915	Opioid proenkephalin pathway	P05994	G-protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02781	Threonine biosynthesis	P03188	Homoserine dehydrogenase	STRCO|Gene=CAC33918|UniProtKB=Q9ADB4	Homoserine dehydrogenase	ISS			PTHR43331:SF1	SUBFAMILY NOT NAMED
P05917	Opioid proopiomelanocortin pathway	P06011	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00006	Apoptosis signaling pathway	P00321	HSP70	ANOGA|EnsemblGenome=AGAP002076|UniProtKB=A7UVK8	AGAP002076-PA	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MACMU|Ensembl=ENSMMUG00000019112|UniProtKB=F6T8S6	N-methyl D-aspartate receptor subtype 2B	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000006232|UniProtKB=H2Q845	Serine/threonine-protein kinase	ISS	8078925	PubMed	PTHR22968:SF9	SERINE/THREONINE-PROTEIN KINASE D1
P00010	B cell activation	P00375	Calmodulin	HUMAN|HGNC=1442|UniProtKB=P62158	Calmodulin	IDA	7514101	PubMed	PTHR23050:SF311	CALMODULIN
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	MACMU|Ensembl=ENSMMUG00000012718|UniProtKB=F7DF35	Uncharacterized protein	ISS	7637782	PubMed	PTHR11647:SF56	DIHYDROPYRIMIDINASE-RELATED PROTEIN 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CAEBR|Gene=CBG03901|UniProtKB=A8WVP7	Protein CBR-HUM-7	ISS			PTHR13140:SF550	HEAVY CHAIN, UNCONVENTIONAL MYOSIN
P00018	EGF receptor signaling pathway	P00552	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00005	Angiogenesis	P00193	SOS-1	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	RAT|RGD=621515|UniProtKB=P61954	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	ISS			PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00006	Apoptosis signaling pathway	P00260	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00388	PLC gamma2	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00056	VEGF signaling pathway	P01418	Paxillin	PANTR|Ensembl=ENSPTRG00000008048|UniProtKB=H2R4E5	Transforming growth factor beta 1 induced transcript 1	ISS			PTHR24216:SF27	TRANSFORMING GROWTH FACTOR BETA-1-INDUCED TRANSCRIPT 1 PROTEIN
P06664	Gonadotropin-releasing hormone receptor pathway	P06812	L-type Ca2+	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	RCA	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05731	GABA-B receptor II signaling	P05754	Ggamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00060	Ubiquitin proteasome pathway	P01492	E1	ARATH|TAIR=AT5G45900|UniProtKB=Q94CD5	Ubiquitin-like modifier-activating enzyme atg7	ISS			PTHR10953:SF3	UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	PANTR|Ensembl=ENSPTRG00000001477|UniProtKB=H2Q0A5	Tyrosine-protein kinase receptor	ISS	12644000	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04393	Ras Pathway	P04556	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	MOUSE|MGI=MGI=2444087|UniProtKB=Q8JZR4	Excitatory amino acid transporter 5	IC	94365697	PubMed	PTHR11958:SF22	EXCITATORY AMINO ACID TRANSPORTER 5
P00057	Wnt signaling pathway	P01433	SIAH-1	XENTR|Xenbase=XB-GENE-1014415|UniProtKB=Q5FVA4	E3 ubiquitin-protein ligase	ISS	11389839	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	BOVIN|Gene=ADRB1|UniProtKB=Q9TT96	Beta-1 adrenergic receptor	IDA	12063255	PubMed	PTHR24248:SF54	BETA-1 ADRENERGIC RECEPTOR
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DANRE|ZFIN=ZDB-GENE-040625-35|UniProtKB=Q6IQL9	Novel actin protein	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00059	p53 pathway	P04609	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	ISS	1171954	gi	PTHR10048:SF14	PI-3 KINASE
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT4G36450|UniProtKB=O23236	Mitogen-activated protein kinase 14	ISS	11707292	PubMed	PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	IDA	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04393	Ras Pathway	P04553	PAK	MACMU|Ensembl=ENSMMUG00000001387|UniProtKB=F7D0B4	Uncharacterized protein	ISS	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00474	Wnt	BOVIN|Ensembl=ENSBTAG00000022671|UniProtKB=F1MZV4	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	BRAFL|Gene=BRAFLDRAFT_220697|UniProtKB=C3ZSF0	Putative uncharacterized protein	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00021	FGF signaling pathway	P00627	ERK1-2	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	IC	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P02748	Isoleucine biosynthesis	P02998	Dihydroxyacid dehydratase	AQUAE|EnsemblGenome=aq_837|UniProtKB=O67009	Dihydroxy-acid dehydratase	ISS			PTHR43661:SF3	DIHYDROXY-ACID DEHYDRATASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IDA	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	HALSA|EnsemblGenome=VNG_0628G|UniProtKB=Q9HRM7	NADP-specific glutamate dehydrogenase A1	ISS			PTHR11606:SF13	GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IGI	7937853	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00029	Huntington disease	P00780	Microtubule	ANOGA|EnsemblGenome=AGAP010929|UniProtKB=Q7PSI4	AGAP010929-PA	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00046	Oxidative stress response	P01131	MKP5	RAT|RGD=1310721|UniProtKB=D4A3W6	Dual specificity phosphatase 16 (Predicted)	ISS			PTHR10159:SF37	DUAL SPECIFICITY PROTEIN PHOSPHATASE 16
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00828	Galphai	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	RCA			PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=3784|UniProtKB=P61265	Syntaxin-1B	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00005	Angiogenesis	P00206	Wnt	BRAFL|Gene=BRAFLDRAFT_113720|UniProtKB=C3YYJ8	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=7576|UniProtKB=P13533	Myosin-6	IC	10938134	PubMed	PTHR13140:SF721	MYOSIN-6
P00057	Wnt signaling pathway	P01430	p53	MOUSE|MGI=MGI=98834|UniProtKB=P02340	Cellular tumor antigen p53	IDA	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P04393	Ras Pathway	P04566	Stat 1/3	HUMAN|HGNC=11362|UniProtKB=P42224	Signal transducer and activator of transcription 1-alpha/beta	IDA	14755057	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00034	Integrin signalling pathway	P00919	Arf6	ORNAN|Ensembl=ENSOANG00000013982|UniProtKB=F6URT1	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00006	Apoptosis signaling pathway	P00293	PKR	PANTR|Ensembl=ENSPTRG00000011834|UniProtKB=H2QHR3	Uncharacterized protein	ISS	11555640	PubMed	PTHR11042:SF102	INTERFERON-INDUCED, DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MOUSE|MGI=MGI=98729|UniProtKB=Q62312	TGF-beta receptor type-2	TAS	9759503	PubMed	PTHR23255:SF55	TGF-BETA RECEPTOR TYPE-2
P00047	PDGF signaling pathway	P01142	p90RSK	PANTR|Ensembl=ENSPTRG00000003839|UniProtKB=H2Q401	Ribosomal protein S6 kinase	ISS	9792677	PubMed	PTHR24351:SF41	RIBOSOMAL PROTEIN S6 KINASE ALPHA-4
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00018	EGF receptor signaling pathway	P00552	Ras	CAEEL|WormBase=WBGene00002335|UniProtKB=P22981	Ras protein let-60	IGI	12024031	PubMed	PTHR24070:SF385	GTPASE HRAS
P04393	Ras Pathway	P04542	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02775	Salvage pyrimidine ribonucleotides	P03155	Cytosine deaminase	ECOLI|EcoGene=EG11326|UniProtKB=P25524	Cytosine deaminase	RCA			PTHR32027:SF0	CYTOSINE DEAMINASE
P00046	Oxidative stress response	P01129	JNK1/2	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	TAS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DICDI|dictyBase=DDB_G0283903|UniProtKB=Q54QB1	Extracellular signal-regulated kinase 2	IDA	12787066	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	HUMAN|HGNC=7569|UniProtKB=P35749	Myosin-11	ISS	89264452	PubMed	PTHR13140:SF335	MYOSIN-11
P02771	Pyrimidine Metabolism	P03131	5'-Nucleotidase	MOUSE|MGI=MGI=99782|UniProtKB=Q61503	5'-nucleotidase	IDA	8224905	PubMed	PTHR11575:SF25	5'-NUCLEOTIDASE
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MOUSE|MGI=MGI=1346873|UniProtKB=Q61083	Mitogen-activated protein kinase kinase kinase 2	ISS	8621389	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00038	JAK/STAT signaling pathway	P01027	STAT	CANLF|Ensembl=ENSCAFG00000015346|UniProtKB=E2RE22	Signal transducer and activator of transcription	ISS	7514531	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00021	FGF signaling pathway	P00645	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12932731	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	SCHMA|EnsemblGenome=Smp_183710|UniProtKB=G4VLW1	Putative actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	P01451	Galpha	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01185	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00005	Angiogenesis	P00249	PAK	HUMAN|HGNC=8590|UniProtKB=Q13153	Serine/threonine-protein kinase PAK 1	IDA	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00021	FGF signaling pathway	P00644	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00238	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000002775|UniProtKB=H2RB55	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MOUSE|MGI=MGI=1309999|UniProtKB=Q922R0	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00008	Axon guidance mediated by Slit/Robo	P00342	Slit	DANRE|ZFIN=ZDB-GENE-010306-4|UniProtKB=F1RCV3	Uncharacterized protein	ISS			PTHR24373:SF15	SLIT HOMOLOG 3 PROTEIN
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00029	Huntington disease	P00790	beta-Tubulin	TRYB2|Gene=TB927.1.2330|UniProtKB=Q4GYY6	Beta tubulin	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P02722	Acetate utilization	P02801	Acetate kinase	STRCO|EnsemblGenome=CAB70654|UniProtKB=Q9L298	Acetate kinase	ISS			PTHR21060:SF11	SUBFAMILY NOT NAMED
P02742	Tetrahydrofolate biosynthesis	P02944	Phosphoribosylglycinamide formyltransferase	DEIRA|EnsemblGenome=DR_0584|UniProtKB=Q9RWT1	Formyltetrahydrofolate deformylase	ISS			PTHR42706:SF1	FORMYLTETRAHYDROFOLATE DEFORMYLASE 1, MITOCHONDRIAL-RELATED
P06959	CCKR signaling map	G07262	HDC	HUMAN|HGNC=4855|UniProtKB=P19113	Histidine decarboxylase	RCA	8928792	PubMed	PTHR11999:SF68	HISTIDINE DECARBOXYLASE
P00036	Interleukin signaling pathway	P00973	PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	MOUSE|MGI=MGI=88296|UniProtKB=O55017	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	15079861	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00018	EGF receptor signaling pathway	P00539	14-3-3	NEUCR|EnsemblGenome=EFNCRG00000002359|UniProtKB=Q7RVK6	14-3-3 family protein 7	ISS	12063166	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P02728	Arginine biosynthesis	P02848	N-acetylglutamate synthase	MACMU|Ensembl=ENSMMUG00000009713|UniProtKB=F7A376	Uncharacterized protein	ISS			PTHR23342:SF0	N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL
P00019	Endothelin signaling pathway	P00589	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00045	Notch signaling pathway	P01103	Next	BOVIN|Ensembl=ENSBTAG00000012817|UniProtKB=E1BDN7	Delta-like protein	ISS	10551863	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00019	Endothelin signaling pathway	P00566	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9836512	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00029	Huntington disease	P00807	Actin	DROME|FlyBase=FBgn0000047|UniProtKB=P83967	Actin, indirect flight muscle	IDA	10974003	PubMed	PTHR11937:SF368	ACTIN, INDIRECT FLIGHT MUSCLE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01443	Phospholipase C	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00047	PDGF signaling pathway	P01160	IP3 receptor	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	RAT|RGD=1309574|UniProtKB=D3ZFS0	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF84	PROTEIN WNT-9B
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00005	Angiogenesis	P00243	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00057	Wnt signaling pathway	P01443	Phospholipase C	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00005	Angiogenesis	P00243	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04565	MKK4/7	CHICK|Ensembl=ENSGALG00000001001|UniProtKB=F1P3T1	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00059	p53 pathway	P04610	Cyclin E	STRPU|EnsemblGenome=SPU_001712|UniProtKB=W4XEA0	Uncharacterized protein	ISS	98112190	PubMed	PTHR10177:SF344	G1/S-SPECIFIC CYCLIN-E
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00019	Endothelin signaling pathway	P00570	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	10477300	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00010	B cell activation	P00368	vav	CANLF|Ensembl=ENSCAFG00000019951|UniProtKB=F1PET4	Uncharacterized protein	ISS	14623913	PubMed	PTHR22826:SF97	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	HUMAN|HGNC=6162|UniProtKB=P26010	Integrin beta-7	IDA	3487386	PubMed	PTHR10082:SF36	INTEGRIN BETA-7
P04393	Ras Pathway	P04572	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00012	Cadherin signaling pathway	P00473	P120	HUMAN|HGNC=2516|UniProtKB=Q9UQB3	Catenin delta-2	ISS			PTHR10372:SF9	CATENIN DELTA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	RAT|RGD=2740|UniProtKB=Q62645	Glutamate receptor ionotropic, NMDA 2D	IC	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2D.html	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IDA	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00054	Toll receptor signaling pathway	P01369	MKK1	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00059	p53 pathway	P01486	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00932	FAK	HUMAN|HGNC=9611|UniProtKB=Q05397	Focal adhesion kinase 1	IPI	9182576	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00035	Interferon-gamma signaling pathway	P00956	SOCS	HUMAN|HGNC=29846|UniProtKB=O14512	Suppressor of cytokine signaling 7	ISS	15032587	PubMed	PTHR45052:SF1	SUPPRESSOR OF CYTOKINE SIGNALING 7
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	RAT|RGD=61986|UniProtKB=P97711	G protein-coupled receptor kinase 6	IDA	12032308	PubMed	PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P00018	EGF receptor signaling pathway	P00546	GAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	IGI	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00021	FGF signaling pathway	P00624	14-3-3	TAKRU|Ensembl=ENSTRUG00000004697|UniProtKB=H2SFG7	Uncharacterized protein	ISS	91108808	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	HUMAN|HGNC=7573|UniProtKB=P11055	Myosin-3	ISS	89264452	PubMed	PTHR13140:SF427	MYOSIN-3
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	PANTR|Ensembl=ENSPTRG00000010617|UniProtKB=H2QFL8	Notch 3	ISS	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00018	EGF receptor signaling pathway	P00560	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	RAT|RGD=69430|UniProtKB=P32851	Syntaxin-1A	ISS	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00044	Nicotinic acetylcholine receptor signaling pathway	P01095	beta	CHICK|Gene=CHRNB4|UniProtKB=P26153	Neuronal acetylcholine receptor subunit beta-4 (Fragment)	ISS	22213672	PubMed	PTHR18945:SF385	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-4
P04375	5HT3 type receptor mediated signaling pathway	P04422	5HT3 Rec	HUMAN|HGNC=5297|UniProtKB=P46098	5-hydroxytryptamine receptor 3A	ISS	7509203	PubMed	PTHR18945:SF52	5-HYDROXYTRYPTAMINE RECEPTOR 3A
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00019	Endothelin signaling pathway	P00581	Guanylate cyclase	MACMU|Ensembl=ENSMMUG00000005447|UniProtKB=F7HEA7	Guanylate cyclase soluble subunit beta-1	RCA			PTHR11920:SF318	GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00729	Goalpha	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	IDA	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	MACMU|Ensembl=ENSMMUG00000017022|UniProtKB=F7HQZ9	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TRIVA|Gene=TVAG_090470|UniProtKB=A2FA04	Actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00623	FGF	XENTR|Xenbase=XB-GENE-479999|UniProtKB=F6QPE1	Fibroblast growth factor	ISS	11376006	PubMed	PTHR11486:SF17	FIBROBLAST GROWTH FACTOR 12
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05731	GABA-B receptor II signaling	P05755	Gbeta	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04397	p53 pathway by glucose deprivation	P04641	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00010	B cell activation	P00381	Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	IGI	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	RAT|RGD=628852|UniProtKB=Q02294	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	8386525	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00029	Huntington disease	P00799	JNK-2	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P02746	Heme biosynthesis	P02980	Coproporphyrinogen Oxidase (oxygen dependent)	RAT|RGD=1311817|UniProtKB=Q3B7D0	Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial	ISS			PTHR10755:SF0	OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	RAT|RGD=69424|UniProtKB=Q99P84	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	10934033	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00029	Huntington disease	P00786	ARF	TAKRU|Ensembl=ENSTRUG00000017307|UniProtKB=H2VAQ1	Uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IPI	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04393	Ras Pathway	P04569	Cdc42	MACMU|Ensembl=ENSMMUG00000022009|UniProtKB=F6RBZ7	Cell division control protein 42 homolog isoform 2	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00057	Wnt signaling pathway	P01435	SWI/SNF	SCHPO|PomBase=SPAC1250.01|UniProtKB=Q9UTN6	Chromatin structure-remodeling complex subunit snf21	ISS	11532957	PubMed	PTHR10799:SF854	ATP-DEPENDENT HELICASE BRM
P00019	Endothelin signaling pathway	P00566	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00036	Interleukin signaling pathway	P00990	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01320	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000023202|UniProtKB=F7EU36	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05913	Enkephalin release	P05972	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00059	p53 pathway	P01486	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01307	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IGI	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00046	Oxidative stress response	P01134	cPLA2	PANTR|Ensembl=ENSPTRG00000001787|UniProtKB=H2Q0T0	Phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00057	Wnt signaling pathway	P01435	SWI/SNF	ARATH|TAIR=AT2G28290|UniProtKB=F4IHS2	Chromatin structure-remodeling complex protein SYD	ISS	11532957	PubMed	PTHR10799:SF854	ATP-DEPENDENT HELICASE BRM
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01430	p53	PANTR|Ensembl=ENSPTRG00000008703|UniProtKB=H2QC53	Cellular tumor antigen p53	ISS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	MACMU|Ensembl=ENSMMUG00000030358|UniProtKB=F7F3G9	Uncharacterized protein	ISS			PTHR18945:SF489	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-9
P00020	FAS signaling pathway	P00600	PARP	RAT|RGD=1310568|UniProtKB=G3V749	Poly [ADP-ribose] polymerase	ISS	12101391	PubMed	PTHR10459:SF60	POLY  ADP-RIBOSE  POLYMERASE 2
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00047	PDGF signaling pathway	P01162	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05918	p38 MAPK pathway	P06020	p38delta	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00034	Integrin signalling pathway	P00907	ERK	HUMAN|HGNC=6857|UniProtKB=Q99683	Mitogen-activated protein kinase kinase kinase 5	IC			PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CAEEL|WormBase=WBGene00000063|UniProtKB=P0DM41	Actin-1	IC	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00049	Parkinson disease	P01241	TH	HUMAN|HGNC=11782|UniProtKB=P07101	Tyrosine 3-monooxygenase	TAS	12814656	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00054	Toll receptor signaling pathway	P01346	TLR	PANTR|Ensembl=ENSPTRG00000021299|UniProtKB=H2QXS5	Toll-like receptor 4	ISS			PTHR44568:SF1	TOLL-LIKE RECEPTOR 4
P00005	Angiogenesis	P00223	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00029	Huntington disease	P00799	JNK-2	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00012	Cadherin signaling pathway	P00474	Wnt	DANRE|ZFIN=ZDB-GENE-980526-332|UniProtKB=P51028	Protein Wnt-8a	IDA	11266476	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P06959	CCKR signaling map	P07232	CREB1	HUMAN|HGNC=2345|UniProtKB=P16220	Cyclic AMP-responsive element-binding protein 1	RCA	9597751	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00048	PI3 kinase pathway	P01192	p110	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00059	p53 pathway	P01486	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	TAS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00011	Blood coagulation	P00458	GP IIIa	MOUSE|MGI=MGI=96612|UniProtKB=O54890	Integrin beta-3	ISS	3487386	PubMed	PTHR10082:SF25	INTEGRIN BETA-3
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	HUMAN|HGNC=2861|UniProtKB=P00374	Dihydrofolate reductase	ISS			PTHR22778:SF39	DIHYDROFOLATE REDUCTASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MOUSE|MGI=MGI=95821|UniProtKB=Q01097	Glutamate receptor ionotropic, NMDA 2B	IC	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	PSEAE|EnsemblGenome=PA3807|UniProtKB=Q59636	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00005	Angiogenesis	P00183	Shc	BOVIN|Ensembl=ENSBTAG00000019838|UniProtKB=Q0IIE2	SHC-transforming protein 1	ISS	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00053	T cell activation	P01306	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	P01444	Wnt	BOVIN|Ensembl=ENSBTAG00000020267|UniProtKB=F1MKX1	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P00010	B cell activation	P00385	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P02734	Chorismate biosynthesis	P02874	Shikimate kinase	BACSU|EnsemblGenome=BSU03150|UniProtKB=P37944	Shikimate kinase	ISS			PTHR21087:SF0	SHIKIMATE KINASE 1
P00018	EGF receptor signaling pathway	P00547	PP2A	HUMAN|HGNC=9300|UniProtKB=P62714	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	NAS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04398	p53 pathway feedback loops 2	P04665	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00575	furin	HUMAN|HGNC=8568|UniProtKB=P09958	Furin	ISS	10956649	PubMed	PTHR42884:SF1	FURIN
P00010	B cell activation	P00379	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02772	Pyruvate metabolism	P03137	Citrate Lyase	STRCO|Gene=CAA22719|UniProtKB=Q9ZBK3	Putative citratelyase	ISS			PTHR32308:SF0	CITRATE LYASE SUBUNIT BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00036	Interleukin signaling pathway	P00996	STAT	HUMAN|HGNC=11366|UniProtKB=P42229	Signal transducer and activator of transcription 5A	IC	95236292	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00053	T cell activation	P01332	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01143	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	20216076	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00049	Parkinson disease	P01219	SAPK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04543	MEKK1/4	MACMU|Ensembl=ENSMMUG00000012387|UniProtKB=F7EB20	Uncharacterized protein	ISS	12049732	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CAEEL|WormBase=WBGene00015412|UniProtKB=O44452	Ligand-Gated ion Channel	IC			PTHR18945:SF557	LIGAND-GATED ION CHANNEL
P06587	Nicotine pharmacodynamics pathway	P06595	CHRNA3	RAT|RGD=2345|UniProtKB=P04757	Neuronal acetylcholine receptor subunit alpha-3	ISS	12098588	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	DROME|FlyBase=FBgn0001991|UniProtKB=Q24270	Voltage-dependent calcium channel type D subunit alpha-1	ISS	8838325	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00539	14-3-3	CANLF|Ensembl=ENSCAFG00000013549|UniProtKB=E2QVP6	Uncharacterized protein	ISS	91108808	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00006	Apoptosis signaling pathway	P00274	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01336	Jnk	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MONDO|Ensembl=ENSMODG00000004360|UniProtKB=F7FAW0	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF335	MYOSIN-11
P05730	Endogenous cannabinoid signaling	P05746	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000005917|UniProtKB=F6QM53	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00017	DNA replication	P00527	Histones	STRPU|EnsemblGenome=SPU_022170|UniProtKB=W4Z226	Histone H3	ISS	12413958	PubMed	PTHR11426:SF20	HISTONE H3-LIKE CENTROMERIC PROTEIN A
P00021	FGF signaling pathway	P00648	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IGI	22246731	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000007882|UniProtKB=G3X7Z2	Uncharacterized protein	ISS	14507926	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00021	FGF signaling pathway	P00643	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00054	Toll receptor signaling pathway	P01346	TLR	MACMU|Ensembl=ENSMMUG00000014254|UniProtKB=B3Y653	Toll-like receptor 7	ISS			PTHR44312:SF1	TOLL-LIKE RECEPTOR 7
P00037	Ionotropic glutamate receptor pathway	P01015	Glu4	CHICK|Ensembl=ENSGALG00000017178|UniProtKB=F1N982	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	CAEEL|WormBase=WBGene00000424|UniProtKB=Q03206	Ras-related protein ced-10	ISS			PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CHICK|Gene=ACTA2|UniProtKB=P08023	Actin, aortic smooth muscle	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00045	Notch signaling pathway	P01101	Su(H)	RAT|RGD=1310557|UniProtKB=F1LNW1	Protein Rbpj	ISS	9528780	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CAEBR|Gene=CBG03310|UniProtKB=A8WSB6	Protein CBR-ACR-7	ISS			PTHR18945:SF426	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-TYPE ACR-7
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	CHICK|Ensembl=ENSGALG00000014975|UniProtKB=F1NTE9	Uncharacterized protein	ISS	9700720	PubMed	PTHR43893:SF8	D 1B  DOPAMINE RECEPTOR
P00059	p53 pathway	P01480	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00053	T cell activation	P01294	NFAT	MACMU|Ensembl=ENSMMUG00000003370|UniProtKB=F7E8G2	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00009	Axon guidance mediated by netrin	P00366	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05916	Opioid prodynorphin pathway	P06000	vasopressin	RAT|RGD=3238|UniProtKB=P01179	Oxytocin-neurophysin 1	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IDA	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MOUSE|MGI=MGI=95770|UniProtKB=P30678	Guanine nucleotide-binding protein subunit alpha-15	IDA	8838318	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00624	14-3-3	CAEEL|WormBase=WBGene00001502|UniProtKB=Q20655	14-3-3-like protein 2	ISS	97315111	PubMed	PTHR18860:SF13	14-3-3 PROTEIN ZETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	DANRE|ZFIN=ZDB-GENE-030131-2299|UniProtKB=F1R966	Clathrin heavy chain	ISS	9388255	PubMed	PTHR10292:SF1	CLATHRIN HEAVY CHAIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P05913	Enkephalin release	P05974	G-Protein (i)	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	IC	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347740|UniProtKB=E9FXV8	Cytoplasmatic actin	ISS	11889126	PubMed	PTHR11937:SF277	SUBFAMILY NOT NAMED
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01067	AChE	MOUSE|MGI=MGI=87876|UniProtKB=P21836	Acetylcholinesterase	IC			PTHR43918:SF3	ACETYLCHOLINESTERASE
P00018	EGF receptor signaling pathway	P00544	c-Cbl	PANTR|Ensembl=ENSPTRG00000015184|UniProtKB=H2QN18	Cas-Br-M (Murine) ecotropic retroviral transforming sequence b	ISS	95303504	PubMed	PTHR23007:SF3	E3 UBIQUITIN-PROTEIN LIGASE CBL-B
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00021	FGF signaling pathway	P00641	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00046	Oxidative stress response	P01122	TRX	YEAST|SGD=S000003441|UniProtKB=P22803	Thioredoxin-2	ISS			PTHR10438:SF284	THIOREDOXIN-LIKE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00640	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00048	PI3 kinase pathway	P01198	FOXO	RAT|RGD=1561201|UniProtKB=D4A433	Protein Foxo4	ISS			PTHR11829:SF188	FORKHEAD BOX PROTEIN O4
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	10218114	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00018	EGF receptor signaling pathway	P00562	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	ENTHI|EnsemblGenome=EHI_197840|UniProtKB=C4M8K6	Rho family GTPase	ISS			PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00009	Axon guidance mediated by netrin	P00364	cdc42	MACMU|Ensembl=ENSMMUG00000022009|UniProtKB=F6RBZ7	Cell division control protein 42 homolog isoform 2	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00014	Cholesterol biosynthesis	P00494	Squalene monooxygenas	CANAL|CGD=CAL0000179458|UniProtKB=Q92206	Squalene monooxygenase	ISS			PTHR10835:SF0	SQUALENE MONOOXYGENASE
P00005	Angiogenesis	P00238	Ras	XENTR|Xenbase=XB-GENE-494548|UniProtKB=F7EC26	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00391	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00060	Ubiquitin proteasome pathway	P01491	E2	DANRE|ZFIN=ZDB-GENE-030131-551|UniProtKB=A9JRT4	Uncharacterized protein	ISS			PTHR24068:SF120	UBIQUITIN-CONJUGATING ENZYME E2D 2  UBC4/5 HOMOLOG, YEAST
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	ORNAN|Ensembl=ENSOANG00000013961|UniProtKB=F6VPY1	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CHICK|Ensembl=ENSGALG00000008898|UniProtKB=F1P2J9	Uncharacterized protein	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	BOVIN|Ensembl=ENSBTAG00000013790|UniProtKB=E1B847	Uncharacterized protein	ISS	12168099	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	ORYSJ|EnsemblGenome=OS01G0641000|UniProtKB=Q8LQ53	Os01g0641000 protein	ISS			PTHR44084:SF2	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7-LIKE-RELATED
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04395	Vasopressin synthesis	P04593	Glycopeptide	MACMU|Ensembl=ENSMMUG00000010678|UniProtKB=F7AXI7	Uncharacterized protein	ISS	3768139	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00013	Cell cycle	P00480	Proteasome	SCHPO|PomBase=SPAC637.10c|UniProtKB=O94444	26S proteasome regulatory subunit rpn10	ISS	21848401	PubMed	PTHR10223:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	BACSU|EnsemblGenome=BSU17680|UniProtKB=P0CI79	Thymidylate synthase 1	ISS			PTHR11548:SF1	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	MOUSE|MGI=MGI=1355272|UniProtKB=Q9DC28	Casein kinase I isoform delta	IDA	10617630	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P04393	Ras Pathway	P04557	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00012	Cadherin signaling pathway	P00474	Wnt	BOVIN|Ensembl=ENSBTAG00000014291|UniProtKB=A6H6X8	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P02772	Pyruvate metabolism	P03139	Lactate Dehydrogenase	TRIVA|Gene=TVAG_371320|UniProtKB=A2FYF4	Lactate dehydrogenase isozyme 2	ISS	12044143	gi	PTHR23382:SF0	MALATE DEHYDROGENASE 2, MITOCHONDRIAL-RELATED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00057	Wnt signaling pathway	P01429	Axin	DANRE|ZFIN=ZDB-GENE-000403-1|UniProtKB=P57094	Axin-1	IDA	12356903	PubMed	PTHR10845:SF11	AXIN-1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	YEAST|SGD=S000005627|UniProtKB=P01119	Ras-like protein 1	ISS	7997267	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	MACMU|Ensembl=ENSMMUG00000010184|UniProtKB=F6SR09	Uncharacterized protein	ISS	7476890	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00059	p53 pathway	P04622	Sin3	CHICK|Ensembl=ENSGALG00000001644|UniProtKB=E1BX21	Uncharacterized protein	ISS	10441327	PubMed	PTHR12346:SF2	PAIRED AMPHIPATHIC HELIX PROTEIN SIN3A
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00019	Endothelin signaling pathway	P00570	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00034	Integrin signalling pathway	P00928	alpha actinin	CANLF|Ensembl=ENSCAFG00000010822|UniProtKB=E2QUQ0	Uncharacterized protein	ISS	2116421	PubMed	PTHR43947:SF4	ALPHA-ACTININ-2
P00006	Apoptosis signaling pathway	P00310	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IDA	12660731	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00046	Oxidative stress response	P01129	JNK1/2	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00005	Angiogenesis	P00189	Fzd	RAT|RGD=71012|UniProtKB=Q08464	Frizzled-2	ISS	11212302	PubMed	PTHR11309:SF34	FRIZZLED-2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00017	DNA replication	P00536	DNA Topisomerase	PANTR|Ensembl=ENSPTRG00000013498|UniProtKB=H2QKC9	Topoisomerase (DNA) I	ISS			PTHR10290:SF5	DNA TOPOISOMERASE 1
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00036	Interleukin signaling pathway	P00977	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	RCA	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00034	Integrin signalling pathway	P00907	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00223	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00640	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IGI	129387	gi	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IGI	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	XENTR|Xenbase=XB-GENE-484003|UniProtKB=Q6P365	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04397	p53 pathway by glucose deprivation	P04641	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04556	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00976	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00047	PDGF signaling pathway	P01173	STAT	BOVIN|Gene=STAT3|UniProtKB=P61635	Signal transducer and activator of transcription 3	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	ORNAN|Ensembl=ENSOANG00000010302|UniProtKB=F6TDQ6	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IGI	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04398	p53 pathway feedback loops 2	P04651	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00053	T cell activation	P01306	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00018	EGF receptor signaling pathway	P00551	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IGI	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00010	B cell activation	P00388	PLC gamma2	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00047	PDGF signaling pathway	P01169	Vav	RAT|RGD=1306285|UniProtKB=D3ZYG0	Protein Vav2	ISS	14623913	PubMed	PTHR22826:SF95	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV2
P00060	Ubiquitin proteasome pathway	P01492	E1	ARATH|TAIR=AT5G06460|UniProtKB=P92974	Ubiquitin-activating enzyme E1 2	ISS			PTHR10953:SF4	GH24511P
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00036	Interleukin signaling pathway	P00964	p90RSK	BOVIN|Ensembl=ENSBTAG00000014447|UniProtKB=A4IFF4	Ribosomal protein S6 kinase	ISS	12769834	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00053	T cell activation	P01294	NFAT	RAT|RGD=1310749|UniProtKB=D3Z9H7	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	ISS	9133421	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	RAT|RGD=3139|UniProtKB=Q29RW1	Myosin-4	ISS	10938134	PubMed	PTHR13140:SF657	MYOSIN-4
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05913	Enkephalin release	P05975	GPCR (s)	RAT|RGD=3234|UniProtKB=P33535	Mu-type opioid receptor	ISS	11259498	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P02746	Heme biosynthesis	P02974	Uroporphyrinogen-III synthase	PANTR|Ensembl=ENSPTRG00000003042|UniProtKB=H2Q2R3	Uncharacterized protein	ISS			PTHR12390:SF0	UROPORPHYRINOGEN-III SYNTHASE
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	CHICK|Gene=CSNK1A1|UniProtKB=P67962	Casein kinase I isoform alpha	ISS	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00057	Wnt signaling pathway	P01465	Ggamma	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P06664	Gonadotropin-releasing hormone receptor pathway	G06903	3' LHbeta	MOUSE|MGI=MGI=96782|UniProtKB=O09108	Lutropin subunit beta	RCA			PTHR11515:SF11	LUTROPIN SUBUNIT BETA
P04393	Ras Pathway	P04578	Rho	XENTR|Xenbase=XB-GENE-941426|UniProtKB=Q28HZ4	Novel Rho protein	ISS	15668138	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00892	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	HUMAN|HGNC=9508|UniProtKB=P49768	Presenilin-1	IDA	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04398	p53 pathway feedback loops 2	P04651	Ras	MONDO|Ensembl=ENSMODG00000025248|UniProtKB=F7F5X1	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00048	PI3 kinase pathway	P01198	FOXO	RAT|RGD=1309196|UniProtKB=D3ZBQ1	Forkhead box O3a (Predicted)	ISS	10102273	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ORYSJ|EnsemblGenome=OS03G0285800|UniProtKB=Q10N20	Mitogen-activated protein kinase 5	ISS	10514528	PubMed	PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00373	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00006	Apoptosis signaling pathway	P00269	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	EMENI|EnsemblGenome=CADANIAG00000581|UniProtKB=G5EAY4	CD42_CHICK Cell division control protein 42 homolog (G25K GTP-binding protein)	ISS			PTHR24072:SF192	CDC42 HOMOLOG
P02765	Phenylalanine biosynthesis	P03099	Prephenate dehydratase	THEMA|EnsemblGenome=TM_0155|UniProtKB=Q9WY02	Chorismate mutase/prephenate dehydratase	ISS			PTHR21022:SF0	PREPHENATE DEHYDRATASE-RELATED
P00059	p53 pathway	G01568	KILLER/DR5	PANTR|Ensembl=ENSPTRG00000020070|UniProtKB=H2QVV8	Uncharacterized protein	ISS	9242611	PubMed	PTHR23097:SF88	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10B
P02768	Proline biosynthesis	P03114	Glutamyl kinase	ECOLI|EcoGene=EG10768|UniProtKB=P0A7B5	Glutamate 5-kinase	ISS			PTHR43654:SF3	GLUTAMATE 5-KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	RAT|RGD=620630|UniProtKB=Q9QYN8	Histamine H3 receptor	IDA			PTHR44152:SF4	HISTAMINE H3 RECEPTOR
P00018	EGF receptor signaling pathway	P00549	EGF	RAT|RGD=620299|UniProtKB=Q9Z0L5	Proepiregulin	ISS			PTHR10740:SF11	PROEPIREGULIN
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00009	Axon guidance mediated by netrin	P00366	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	20264070	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DROME|FlyBase=FBgn0000043|UniProtKB=P02572	Actin-42A	ISS	14684598	PubMed	PTHR11937:SF369	ACTIN-42A
P00047	PDGF signaling pathway	P01161	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00779	TBP	YEAST|SGD=S000000950|UniProtKB=P13393	TATA-box-binding protein	IPI	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00047	PDGF signaling pathway	P01162	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	ORYSJ|EnsemblGenome=OS01G0207300|UniProtKB=Q8LRJ3	Os01g0207300 protein	ISS			PTHR11964:SF1	S-ADENOSYLMETHIONINE SYNTHASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_114535|UniProtKB=C3ZHN2	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12805548	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=108061|UniProtKB=P48614	Protein Wnt-10b	TAS	11266476	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00048	PI3 kinase pathway	P01188	Gbetagamma	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05916	Opioid prodynorphin pathway	P06002	G-protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	HUMAN|HGNC=3087|UniProtKB=Q92997	Segment polarity protein dishevelled homolog DVL-3	TAS	11212302	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P00048	PI3 kinase pathway	P01188	Gbetagamma	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P05916	Opioid prodynorphin pathway	P06002	G-protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	XENTR|GeneID=394982|UniProtKB=P20399	Actin, alpha cardiac muscle 2	ISS	11889139	PubMed	PTHR11937:SF263	ACTIN
P00048	PI3 kinase pathway	P01185	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00010	B cell activation	P00383	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P02744	Fructose galactose metabolism	P02964	Hexose 1-P uridyltransferase	HUMAN|HGNC=4135|UniProtKB=P07902	Galactose-1-phosphate uridylyltransferase	IDA	1610789	PubMed	PTHR11943:SF1	GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MACMU|Ensembl=ENSMMUG00000014227|UniProtKB=P56490	Muscarinic acetylcholine receptor M5	TAS	12181435	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00053	T cell activation	P01335	jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	11840290	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00010	B cell activation	P00402	Jnk	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	MOUSE|MGI=MGI=96433|UniProtKB=Q60751	Insulin-like growth factor 1 receptor	ISS	11182407	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00627	ERK1-2	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	IC	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ARATH|TAIR=AT1G45000|UniProtKB=Q9MAK9	26S protease regulatory subunit S10B homolog B	ISS			PTHR23073:SF58	26S PROTEASE REGULATORY SUBUNIT 10B HOMOLOG A-RELATED
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	MACMU|Ensembl=ENSMMUG00000000983|UniProtKB=F6SYL4	Fructose-bisphosphate aldolase	ISS	3391172	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00059	p53 pathway	G04694	p110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00053	T cell activation	P01311	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	IEA	12068308	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P06664	Gonadotropin-releasing hormone receptor pathway	P06820	alpha-beta integrin dimer	MOUSE|MGI=MGI=96610|UniProtKB=P09055	Integrin beta-1	RCA	3487386	PubMed	PTHR10082:SF28	INTEGRIN BETA-1
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	MOUSE|MGI=MGI=106217|UniProtKB=Q61290	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	11976940	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00029	Huntington disease	P00790	beta-Tubulin	BOVIN|Ensembl=ENSBTAG00000004624|UniProtKB=E1B953	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00572	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00182	p38MAPK	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00052	TGF-beta signaling pathway	P01275	P38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00036	Interleukin signaling pathway	P00970	Interleukin	MOUSE|MGI=MGI=103014|UniProtKB=P48346	Interleukin-15	IC	12381348	PubMed	PTHR45114:SF1	INTERLEUKIN-15
P02723	Adenine and hypoxanthine salvage pathway	P02809	Xanthine dehydrogenase	CAEEL|WormBase=WBGene00015057|UniProtKB=Q960A1	Probable aldehyde oxidase gad-3	ISS			PTHR11908:SF102	ALDEHYDE OXIDASE GAD-3-RELATED
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00034	Integrin signalling pathway	P00907	ERK	MONDO|Ensembl=ENSMODG00000006594|UniProtKB=F7AKA6	Uncharacterized protein	ISS			PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00022	General transcription by RNA polymerase I	P00655	UBF1	BOVIN|Ensembl=ENSBTAG00000005067|UniProtKB=F1MCZ7	Uncharacterized protein	ISS	14612424	PubMed	PTHR13711:SF216	NUCLEOLAR TRANSCRIPTION FACTOR 1
P04393	Ras Pathway	P04567	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=16267|UniProtKB=Q9UBV4	Protein Wnt-16	IDA	11266476	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P00001	Adrenaline and noradrenaline biosynthesis	P00067	MAO	XENTR|Xenbase=XB-GENE-5749883|UniProtKB=F6V922	Uncharacterized protein (Fragment)	ISS	90344230	PubMed	PTHR43563:SF2	AMINE OXIDASE  FLAVIN-CONTAINING
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00310	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00624	14-3-3	PANTR|Ensembl=ENSPTRG00000013529|UniProtKB=H2R8X6	Uncharacterized protein	ISS	91108808	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	10693759	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00187	beta catenin	PANTR|Ensembl=ENSPTRG00000023062|UniProtKB=H2R2U1	Catenin (Cadherin-associated protein), beta 1, 88kDa	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P02741	Flavin biosynthesis	P02936	FAD synthetase	CHLTR|EnsemblGenome=CT_093|UniProtKB=O84095	Riboflavin biosynthesis protein	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00057	Wnt signaling pathway	P01451	Galpha	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	IDA	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IGI	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	MOUSE|MGI=MGI=87888|UniProtKB=O70174	Neuronal acetylcholine receptor subunit alpha-4	ISS	85270494	PubMed	PTHR18945:SF401	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4
P00021	FGF signaling pathway	P00627	ERK1-2	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00015	Circadian clock system	P00504	Per	PANTR|Ensembl=ENSPTRG00000008726|UniProtKB=H2QC70	Uncharacterized protein	ISS	20570170	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02770	Pyridoxal phosphate salvage pathway	P03123	Pyridoxine-5-phosphate oxidase	DEIRA|EnsemblGenome=DR_0495|UniProtKB=Q9RX20	Pyridoxine/pyridoxamine 5'-phosphate oxidase	ISS	10567266	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00034	Integrin signalling pathway	P00947	Laminin	MACMU|Ensembl=ENSMMUG00000006567|UniProtKB=F7HPY4	Uncharacterized protein	ISS	2538453	PubMed	PTHR10574:SF233	LAMININ SUBUNIT BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	IDA	9851932	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00019	Endothelin signaling pathway	P00589	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01185	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00057	Wnt signaling pathway	P01457	GBeta	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	IDA	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00030	Hypoxia response via HIF activation	P00819	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01135	p38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	TAS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05916	Opioid prodynorphin pathway	P06002	G-protein	CAEEL|WormBase=WBGene00001679|UniProtKB=P17343	Guanine nucleotide-binding protein subunit beta-1	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00053	T cell activation	P01322	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00053	T cell activation	P01306	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	ANOGA|EnsemblGenome=AGAP001573|UniProtKB=Q380U3	AGAP001573-PA	ISS			PTHR24072:SF157	AT17867P
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01417	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00568	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	MONDO|Ensembl=ENSMODG00000001807|UniProtKB=F6Y7R9	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00049	Parkinson disease	P01236	Casein kinase II	CHICK|Ensembl=ENSGALG00000000889|UniProtKB=R9PXL1	Uncharacterized protein	IDA	10806215	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1354946|UniProtKB=Q61532	Mitogen-activated protein kinase 6	IDA	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00059	p53 pathway	P01485	p53	BOVIN|Ensembl=ENSBTAG00000001069|UniProtKB=P67939	Cellular tumor antigen p53	TAS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00057	Wnt signaling pathway	P01443	Phospholipase C	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00021	FGF signaling pathway	P00634	MEKK1-5	MOUSE|MGI=MGI=1346875|UniProtKB=O08648	Mitogen-activated protein kinase kinase kinase 4	IGI	10207617	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00030	Hypoxia response via HIF activation	P00819	AKT	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	TAS	14526383	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01131	MKP5	BOVIN|Ensembl=ENSBTAG00000004587|UniProtKB=Q2KJ36	Dual specificity protein phosphatase 6	ISS			PTHR10159:SF45	DUAL SPECIFICITY PROTEIN PHOSPHATASE 6
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00012	Cadherin signaling pathway	P00471	Cadherin	CANLF|Ensembl=ENSCAFG00000020425|UniProtKB=F1P6U6	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF85	CADHERIN-11
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	HUMAN|HGNC=6264|UniProtKB=P48549	G protein-activated inward rectifier potassium channel 1	IDA	2433589	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00005	Angiogenesis	P00243	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00054	Toll receptor signaling pathway	P01369	MKK1	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00006	Apoptosis signaling pathway	P00260	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P06212	DPP-SCW signaling pathway	P06260	NEJ	DROME|FlyBase=FBgn0261617|UniProtKB=M9MS40	Nejire, isoform C	IGI	10075933	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00005	Angiogenesis	P00256	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	XENTR|Xenbase=XB-GENE-943294|UniProtKB=B0BLT7	Uncharacterized protein	ISS			PTHR12264:SF21	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12
P00053	T cell activation	P01309	fos	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	TAS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00550	Grb2	DANRE|ZFIN=ZDB-GENE-040426-1975|UniProtKB=Q6PC73	Growth factor receptor-bound protein 2	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	NEUCR|EnsemblGenome=EFNCRG00000004240|UniProtKB=Q01386	cAMP-dependent protein kinase regulatory subunit	IC	91298951	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00318	PKCs	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	IDA	3755548	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00012	Cadherin signaling pathway	P00462	Casein kinase II	RAT|RGD=619978|UniProtKB=P67874	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04623	CBP	MACMU|Ensembl=ENSMMUG00000023488|UniProtKB=F7E3A7	Histone acetyltransferase	ISS	10769018	PubMed	PTHR10615:SF73	HISTONE ACETYLTRANSFERASE KAT6B
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	PANTR|Ensembl=ENSPTRG00000012881|UniProtKB=H2QJC4	Uncharacterized protein	ISS			PTHR11405:SF38	CARBAMOYL-PHOSPHATE SYNTHASE  AMMONIA , MITOCHONDRIAL
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05918	p38 MAPK pathway	P06022	eEF2K	CAEEL|WormBase=WBGene00001160|UniProtKB=O01991	Eukaryotic elongation factor 2 kinase	RCA	11500363	PubMed	PTHR14187:SF56	EUKARYOTIC ELONGATION FACTOR 2 KINASE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	ARATH|TAIR=AT5G61210|UniProtKB=Q9S7P9	SNAP25 homologous protein SNAP33	IC			PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	TAS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	PANTR|Ensembl=ENSPTRG00000002979|UniProtKB=H2Q2M8	Uncharacterized protein	ISS	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00014	Cholesterol biosynthesis	P00498	Hydroxymethyl glutaryl CoA synthase	DROME|FlyBase=FBgn0010611|UniProtKB=Q7K4Q9	HMG coenzyme A synthase, isoform A	ISS			PTHR43323:SF2	HMG COENZYME A SYNTHASE, ISOFORM A
P00005	Angiogenesis	P00219	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00015	Circadian clock system	G01500	bmal1	MACMU|Ensembl=ENSMMUG00000009690|UniProtKB=F6XNT8	Uncharacterized protein	ISS	11163178	PubMed	PTHR23042:SF52	ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 1
P00006	Apoptosis signaling pathway	P00269	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02781	Threonine biosynthesis	P03188	Homoserine dehydrogenase	LEPIN|EnsemblGenome=LA_3638|UniProtKB=Q8F059	Homoserine dehydrogenase	ISS			PTHR43331:SF1	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00023	General transcription regulation	P00668	TFIIB	NEUCR|EnsemblGenome=EFNCRG00000007103|UniProtKB=V5IMU9	Transcription initiation factor IIB	ISS	180660	OMIM	PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00391	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01238	14-3-3	CAEBR|Gene=CBG17289|UniProtKB=A8XQR9	14-3-3 zeta	ISS	97315111	PubMed	PTHR18860:SF13	14-3-3 PROTEIN ZETA
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00050	Plasminogen activating cascade	P01257	tPA	PANTR|Ensembl=ENSPTRG00000020201|UniProtKB=H2QW33	Tissue-type plasminogen activator	ISS	6572897	PubMed	PTHR44617:SF1	TISSUE-TYPE PLASMINOGEN ACTIVATOR
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00021	FGF signaling pathway	P00631	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8479536	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MONDO|Ensembl=ENSMODG00000004799|UniProtKB=F6VM87	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00030	Hypoxia response via HIF activation	P00814	P300	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00944	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g242065|UniProtKB=A7S0V7	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00046	Oxidative stress response	P01134	cPLA2	ORNAN|Ensembl=ENSOANG00000001027|UniProtKB=F6QDY0	Phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	RAT|RGD=3425|UniProtKB=P97887	Presenilin-1	TAS	12736250	PubMed	PTHR10202:SF18	PRESENILIN-1
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	MONDO|Ensembl=ENSMODG00000001626|UniProtKB=F6TN69	Uncharacterized protein (Fragment)	ISS	15858232	PubMed	PTHR13715:SF16	RYANODINE RECEPTOR 3
P00019	Endothelin signaling pathway	P00591	PLCbeta	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IGI	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=14550|UniProtKB=Q96JP9	Cadherin-related family member 1	IDA	8120095	PubMed	PTHR44506:SF1	CADHERIN-RELATED FAMILY MEMBER 1
P00057	Wnt signaling pathway	P01457	GBeta	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02777	Succinate to proprionate conversion	P03161	Methylmalonyl-CoA mutase	ORNAN|Ensembl=ENSOANG00000008261|UniProtKB=F6YLX9	Uncharacterized protein	ISS			PTHR42710:SF1	METHYLMALONYL-COA MUTASE, MITOCHONDRIAL
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000010521|UniProtKB=F7DQK7	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00036	Interleukin signaling pathway	P00965	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00018	EGF receptor signaling pathway	P00562	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00049	Parkinson disease	P01211	ERK	HUMAN|HGNC=6880|UniProtKB=Q13164	Mitogen-activated protein kinase 7	IDA	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02741	Flavin biosynthesis	P02934	Riboflavin kinase	AQUAE|EnsemblGenome=aq_139|UniProtKB=O66535	Riboflavin biosynthesis protein	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00053	T cell activation	P01300	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	9298898	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01307	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	CHICK|Ensembl=ENSGALG00000000366|UniProtKB=P18652	Ribosomal protein S6 kinase 2 alpha	ISS	2779569	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00015	Circadian clock system	G01503	per	RAT|RGD=61945|UniProtKB=Q9Z301	Period circadian protein homolog 2	ISS			PTHR11269:SF9	PERIOD CIRCADIAN PROTEIN HOMOLOG 2
P00053	T cell activation	P01309	fos	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	TAS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00048	PI3 kinase pathway	P01202	p85	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00019	Endothelin signaling pathway	P00572	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02728	Arginine biosynthesis	P02842	N-acetylornithine aminotransferase	STRCO|EnsemblGenome=CAB76097|UniProtKB=Q9L1A4	Acetylornithine aminotransferase	ISS	10074354	PubMed	PTHR11986:SF79	ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL
P00036	Interleukin signaling pathway	P00976	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00053	T cell activation	P01307	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P02775	Salvage pyrimidine ribonucleotides	P03156	CDP kinase	DANRE|ZFIN=ZDB-GENE-030131-7158|UniProtKB=Q7SYM0	Uridine-cytidine kinase 2-A	ISS			PTHR10285:SF70	URIDINE-CYTIDINE KINASE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IC	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00561	STAT	DANRE|ZFIN=ZDB-GENE-980526-499|UniProtKB=Q6P943	Signal transducer and activator of transcription	IGI	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P04393	Ras Pathway	P04572	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	RAT|RGD=628852|UniProtKB=Q02294	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	14624853	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00059	p53 pathway	P04630	PP2A	SCHMA|EnsemblGenome=Smp_165490|UniProtKB=C1LZY9	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00274	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04395	Vasopressin synthesis	P04593	Glycopeptide	PANTR|Ensembl=ENSPTRG00000013189|UniProtKB=H2QJV1	Uncharacterized protein	ISS	3768139	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000007523|UniProtKB=Q3SWZ3	Syntaxin-4	ISS			PTHR19957:SF97	SYNTAXIN-4
P00018	EGF receptor signaling pathway	P00551	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00990	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IC	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00629	PP2A	BOVIN|Ensembl=ENSBTAG00000019784|UniProtKB=A4FV68	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	ISS	11007767	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01145	c-fos	PANTR|Ensembl=ENSPTRG00000018189|UniProtKB=H2QT21	Uncharacterized protein	ISS			PTHR11945:SF221	SERUM RESPONSE FACTOR
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	RAT|RGD=1311101|UniProtKB=D4AC20	Cytidine deaminase (Predicted)	ISS			PTHR11644:SF2	CYTIDINE DEAMINASE
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	7937853	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00021	FGF signaling pathway	P00644	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01177	P110ACT	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00025	Hedgehog signaling pathway	P00683	Slimb	MACMU|Ensembl=ENSMMUG00000016008|UniProtKB=F7FVG8	Uncharacterized protein	ISS	10074433	PubMed	PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00036	Interleukin signaling pathway	P00981	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	TAS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IDA	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00005	Angiogenesis	P00193	SOS-1	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	DANRE|ZFIN=ZDB-GENE-040426-2150|UniProtKB=Q6NUX8	Rho-related GTP-binding protein RhoA-A	ISS	14871999	PubMed	PTHR24072:SF260	RHO-RELATED GTP-BINDING PROTEIN RHOA-A-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	IDA	15621031	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00057	Wnt signaling pathway	P01457	GBeta	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IDA	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	TAS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MONDO|Ensembl=ENSMODG00000007194|UniProtKB=F6X9N6	Actin-related protein 2/3 complex subunit 5	ISS	10322212	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CAEEL|WormBase=WBGene00003774|UniProtKB=G5EGQ9	NMDA class glutamate Receptor	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00317	Fos	CANLF|Ensembl=ENSCAFG00000017040|UniProtKB=E2QYK5	Uncharacterized protein	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00647	SHP2	BOVIN|Ensembl=ENSBTAG00000002048|UniProtKB=F1N339	Tyrosine-protein phosphatase non-receptor type	ISS	95163101	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00049	Parkinson disease	P01224	UbcH7	TAKRU|Ensembl=ENSTRUG00000003392|UniProtKB=H2S6C6	Uncharacterized protein	ISS			PTHR24068:SF116	AT26201P-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02748	Isoleucine biosynthesis	P02995	Threonine dehydratase	PSEAE|EnsemblGenome=PA2683|UniProtKB=Q9I0F5	Probable serine/threonine dehydratase, degradative	ISS			PTHR43050:SF1	SERINE RACEMASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT1G59580|UniProtKB=Q39022	Mitogen-activated protein kinase 2	IDA	9836510	gi	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	20384797	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00025	Hedgehog signaling pathway	P00682	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01438	PP2A	PANTR|Ensembl=ENSPTRG00000017238|UniProtKB=H2QRH7	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	HUMAN|HGNC=1401|UniProtKB=Q02641	Voltage-dependent L-type calcium channel subunit beta-1	ISS	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00049	Parkinson disease	P01208	Hsp70	MOUSE|MGI=MGI=95835|UniProtKB=P20029	78 kDa glucose-regulated protein	IDA	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-990415-257|UniProtKB=O42376	Mitogen-activated protein kinase 12	TAS	10851062	PubMed	PTHR24055:SF339	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	MOUSE|MGI=MGI=109482|UniProtKB=P97445	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	14507926	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	3045562	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00006	Apoptosis signaling pathway	P00269	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	MONDO|Ensembl=ENSMODG00000019001|UniProtKB=F7CP86	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04397	p53 pathway by glucose deprivation	P04640	p53	PANTR|Ensembl=ENSPTRG00000015733|UniProtKB=H2QNY5	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00010	B cell activation	P00375	Calmodulin	TAKRU|Ensembl=ENSTRUG00000008685|UniProtKB=H2TXN3	Uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF326	CALMODULIN
P04393	Ras Pathway	P04547	Ras	DAPPU|EnsemblGenome=DAPPUDRAFT_301818|UniProtKB=E9I1I7	Putative uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P05731	GABA-B receptor II signaling	P05752	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	TAS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00642	MEK1-2	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P06959	CCKR signaling map	G07280	CCND1	HUMAN|HGNC=1582|UniProtKB=P24385	G1/S-specific cyclin-D1	RCA	17185632	PubMed	PTHR10177:SF67	G1/S-SPECIFIC CYCLIN-D1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MOUSE|MGI=MGI=1339709|UniProtKB=P13541	Myosin-3	ISS	89264452	PubMed	PTHR13140:SF427	MYOSIN-3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00049	Parkinson disease	P01219	SAPK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P06587	Nicotine pharmacodynamics pathway	P06605	KCNK3/9	MOUSE|MGI=MGI=1100509|UniProtKB=O35111	Potassium channel subfamily K member 3	RCA	11875121	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00005	Angiogenesis	P00209	FAK	PANTR|Ensembl=ENSPTRG00000020624|UniProtKB=H2QWS1	Uncharacterized protein	ISS	9182576	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00049	Parkinson disease	P01238	14-3-3	TAKRU|Ensembl=ENSTRUG00000004697|UniProtKB=H2SFG7	Uncharacterized protein	ISS	1317796	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00024	Glycolysis	P00678	Enolase	HUMAN|HGNC=3350|UniProtKB=P06733	Alpha-enolase	ISS	89079778	PubMed	PTHR11902:SF12	ALPHA-ENOLASE
P00005	Angiogenesis	P00226	Delta/Serrate	DANRE|ZFIN=ZDB-GENE-980526-114|UniProtKB=O57409	Delta-like protein B	ISS			PTHR24044:SF308	DELTA-LIKE PROTEIN 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	PANTR|Ensembl=ENSPTRG00000007489|UniProtKB=H2QA49	Tyrosine-protein kinase receptor	ISS	249616	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P05915	Opioid proenkephalin pathway	P05994	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00029	Huntington disease	P00780	Microtubule	CAEEL|WormBase=WBGene00006536|UniProtKB=O17921	TuBulin, Beta	IDA	9454836	PubMed	PTHR11588:SF157	TUBULIN, BETA
P05918	p38 MAPK pathway	P06021	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	8649368	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00019	Endothelin signaling pathway	P00586	Gq	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	IDA	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00053	T cell activation	P01312	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IDA	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00011	Blood coagulation	P00429	PN2	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	ISS	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P02740	De novo pyrimidine ribonucleotides biosythesis	P02926	Aspartate carbamoyltransferase	DEIRA|EnsemblGenome=DR_1109|UniProtKB=Q9RVC0	Aspartate carbamoyltransferase	ISS			PTHR11405:SF16	ASPARTATE CARBAMOYLTRANSFERASE, CHLOROPLASTIC
P05731	GABA-B receptor II signaling	P05755	Gbeta	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	11313908	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00006	Apoptosis signaling pathway	P00276	TRAIL-R	PANTR|Ensembl=ENSPTRG00000020070|UniProtKB=H2QVV8	Uncharacterized protein	ISS	9242611	PubMed	PTHR23097:SF88	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10B
P02738	De novo purine biosynthesis	P02908	Phosphoribosylamine glycine ligase	MYCTU|EnsemblGenome=Rv0772|UniProtKB=P9WHM9	Phosphoribosylamine--glycine ligase	ISS			PTHR43472:SF1	PHOSPHORIBOSYLAMINE--GLYCINE LIGASE
P00010	B cell activation	P00398	IP3R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00778	NMDA receptor	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	IDA	http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00021	FGF signaling pathway	P00648	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	LEIMA|EnsemblGenome=LmjF.35.4010|UniProtKB=Q9GNR4	Protein kinase A catalytic subunit isoform 1	ISS	14744463	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00053	T cell activation	P01312	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	4506785	gi	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	RAT|RGD=2740|UniProtKB=Q62645	Glutamate receptor ionotropic, NMDA 2D	IC	14698601	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00059	p53 pathway	P04633	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00633	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00005	Angiogenesis	P00234	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	12748278	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	DICDI|dictyBase=DDB_G0276885|UniProtKB=Q02720	Casein kinase II subunit alpha	IDA	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	MACMU|Ensembl=ENSMMUG00000019731|UniProtKB=F7B606	Uncharacterized protein	ISS	10851247	PubMed	PTHR11647:SF58	DIHYDROPYRIMIDINASE-RELATED PROTEIN 5
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00034	Integrin signalling pathway	P00951	Jnk	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00705	Gsalpha	CHICK|Ensembl=ENSGALG00000013785|UniProtKB=E1BS74	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00010	B cell activation	P00384	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04559	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12676940	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00029	Huntington disease	P00776	c-Jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00011	Blood coagulation	P00418	Fibrin monomer	MACMU|Ensembl=ENSMMUG00000021304|UniProtKB=F6UYY8	Uncharacterized protein	ISS	223170	gi	PTHR19143:SF338	FIBRINOGEN GAMMA CHAIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	XENTR|Xenbase=XB-GENE-490534|UniProtKB=F7CQJ3	Uncharacterized protein (Fragment)	ISS	5031595	gi	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	HUMAN|HGNC=10934|UniProtKB=P54219	Chromaffin granule amine transporter	ISS	12135927	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00029	Huntington disease	P00775	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P02723	Adenine and hypoxanthine salvage pathway	P02807	Deoxyadenosine deaminase	SCHPO|PomBase=SPBC1683.02|UniProtKB=Q9P6J8	Uncharacterized deaminase C1683.02	ISS			PTHR43114:SF1	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00048	PI3 kinase pathway	P01199	Galpha	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IGI	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	TAS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00036	Interleukin signaling pathway	P00996	STAT	RAT|RGD=3772|UniProtKB=P52631	Signal transducer and activator of transcription 3	IC	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	MACMU|Ensembl=ENSMMUG00000013100|UniProtKB=F6ZUP6	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF4	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	CANLF|Ensembl=ENSCAFG00000016140|UniProtKB=E2R5K3	Pyrroline-5-carboxylate reductase	ISS			PTHR11645:SF4	PYRROLINE-5-CARBOXYLATE REDUCTASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01410	Caspase9	MACMU|Ensembl=ENSMMUG00000018163|UniProtKB=F7FNC1	Caspase	ISS	11440972	PubMed	PTHR10454:SF157	CASPASE-9
P00006	Apoptosis signaling pathway	P00259	TNF	MACMU|Ensembl=ENSMMUG00000008845|UniProtKB=P48094	Tumor necrosis factor	ISS	11911478	PubMed	PTHR11471:SF23	TUMOR NECROSIS FACTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MACMU|Ensembl=ENSMMUG00000019342|UniProtKB=F6PVY4	Uncharacterized protein	ISS	12473693	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	BOVIN|Ensembl=ENSBTAG00000019988|UniProtKB=F1N2V3	Uncharacterized protein	ISS	11359849	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P00015	Circadian clock system	G01501	cry	MACMU|Ensembl=ENSMMUG00000002453|UniProtKB=F7HH05	Cryptochrome-2	ISS	11533252	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00055	Transcription regulation by bZIP transcription factor	P01394	TFIIF	SCHPO|PomBase=SPAC19B12.05c|UniProtKB=Q9P376	RNA polymerase II subunit A C-terminal domain phosphatase	ISS			PTHR23081:SF0	RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	MONDO|Ensembl=ENSMODG00000012785|UniProtKB=F6S0M5	Uncharacterized protein	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00052	TGF-beta signaling pathway	P01286	TGFbeta	HUMAN|HGNC=4214|UniProtKB=P27539	Embryonic growth/differentiation factor 1	TAS	9759503	PubMed	PTHR11848:SF151	EMBRYONIC GROWTH/DIFFERENTIATION FACTOR 1
P00053	T cell activation	P01294	NFAT	HUMAN|HGNC=7778|UniProtKB=Q14934	Nuclear factor of activated T-cells, cytoplasmic 4	IGI	9462517	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MACMU|Ensembl=ENSMMUG00000014597|UniProtKB=F6VAQ6	Glycogen synthase kinase-3 alpha	ISS	11995474	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P05913	Enkephalin release	P05977	G-Protein (s)	TAKRU|Ensembl=ENSTRUG00000016101|UniProtKB=H2UW32	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00912	Arp2/3	MOUSE|MGI=MGI=1923959|UniProtKB=Q9CVB6	Actin-related protein 2/3 complex subunit 2	ISS	10940259	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	91056091	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MACMU|Ensembl=ENSMMUG00000014807|UniProtKB=F6W548	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00053	T cell activation	P01319	PAK	HUMAN|HGNC=8591|UniProtKB=Q13177	Serine/threonine-protein kinase PAK 2	IDA	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00053	T cell activation	P01336	Jnk	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06007	alpha-MSH	HUMAN|HGNC=9201|UniProtKB=P01189	Pro-opiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00005	Angiogenesis	P00251	cPLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00021	FGF signaling pathway	P00645	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12874273	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00006	Apoptosis signaling pathway	P00322	Cytochrome C	RAT|RGD=1584748|UniProtKB=D4A5L9	Protein LOC679794	ISS	11836241	PubMed	PTHR11961:SF15	CYTOCHROME C
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00748	Gbeta5L	BOVIN|Ensembl=ENSBTAG00000003762|UniProtKB=A5PJS1	GNB5 protein	ISS	10051575	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_114976|UniProtKB=C3YP58	Putative uncharacterized protein	IDA	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00587	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04393	Ras Pathway	P04569	Cdc42	IXOSC|EnsemblGenome=ISCW003614|UniProtKB=B7PHY7	Cdc42 protein, putative	ISS	12932731	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	IC	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00558	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04379	Beta3 adrenergic receptor signaling pathway	P04449	Beta3	RAT|RGD=2061|UniProtKB=P26255	Beta-3 adrenergic receptor	ISS	12063255	PubMed	PTHR24248:SF3	BETA-3 ADRENERGIC RECEPTOR
P00006	Apoptosis signaling pathway	P00313	IKK	CANLF|Ensembl=ENSCAFG00000009588|UniProtKB=E2RNA9	Uncharacterized protein	ISS	12813046	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	IC	2303451	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00223	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01197	Caspase-9	MACMU|Ensembl=ENSMMUG00000018163|UniProtKB=F7FNC1	Caspase	ISS	9390557	PubMed	PTHR10454:SF157	CASPASE-9
P05915	Opioid proenkephalin pathway	P05994	G-protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00012	Cadherin signaling pathway	P00468	Src	MOUSE|MGI=MGI=98397|UniProtKB=P05480	Neuronal proto-oncogene tyrosine-protein kinase Src	ISS	11078745	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00051	TCA cycle	P01267	Citrate Synthase	TAKRU|Ensembl=ENSTRUG00000015248|UniProtKB=H2UPT3	Citrate synthase	ISS	12477932	PubMed	PTHR11739:SF8	CITRATE SYNTHASE, MITOCHONDRIAL
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	CANLF|Ensembl=ENSCAFG00000017516|UniProtKB=E2REK6	Uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF311	CALMODULIN
P00049	Parkinson disease	P01242	Casein kinase I	MACMU|Ensembl=ENSMMUG00000006646|UniProtKB=F7H415	Uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF151	CASEIN KINASE I ISOFORM GAMMA-3
P02775	Salvage pyrimidine ribonucleotides	P03155	Cytosine deaminase	BOVIN|Ensembl=ENSBTAG00000026519|UniProtKB=Q5E9J7	tRNA-specific adenosine deaminase 2	ISS			PTHR11079:SF92	TRNA-SPECIFIC ADENOSINE DEAMINASE 2
P00021	FGF signaling pathway	P00624	14-3-3	CHICK|Ensembl=ENSGALG00000016433|UniProtKB=Q5ZMD1	14-3-3 protein theta	ISS	10407019	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ORYSJ|EnsemblGenome=OS03G0243300|UniProtKB=O82143	26S proteasome regulatory particle	ISS			PTHR10223:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8665|UniProtKB=Q9Y5I1	Protocadherin alpha-11	IDA	8120095	PubMed	PTHR24028:SF68	PROTOCADHERIN ALPHA-11
P00007	Axon guidance mediated by semaphorins	P00334	PlexinA1	CANLF|Ensembl=ENSCAFG00000003989|UniProtKB=F1P6G0	Uncharacterized protein	ISS	10725340	PubMed	PTHR22625:SF35	PLEXIN-A1
P04397	p53 pathway by glucose deprivation	P04647	LKB1	MACMU|Ensembl=ENSMMUG00000022198|UniProtKB=F6ZGN9	Serine/threonine-protein kinase 11	ISS	14985505	PubMed	PTHR44214:SF1	SERINE/THREONINE-PROTEIN KINASE STK11
P00019	Endothelin signaling pathway	P00589	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	IGI	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	ORNAN|Ensembl=ENSOANG00000008874|UniProtKB=F7F2K2	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF23	FRIZZLED-4
P00057	Wnt signaling pathway	P01428	Frizzled	BOVIN|Ensembl=ENSBTAG00000020590|UniProtKB=G3N2W8	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF34	FRIZZLED-2
P00005	Angiogenesis	P00182	p38MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=99578|UniProtKB=Q61616	D(1A) dopamine receptor	ISS			PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00047	PDGF signaling pathway	P01165	SRF	RAT|RGD=1559787|UniProtKB=D3ZHH8	Protein Srf	ISS	15170389	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IGI	1504106	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00022	General transcription by RNA polymerase I	P00649	TAF-IC	DROME|FlyBase=FBgn0002842|UniProtKB=Q9VP40	Spermatocyte arrest	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00018	EGF receptor signaling pathway	P00564	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	CHICK|Gene=CTNNA2|UniProtKB=P30997	Catenin alpha-2	TAS	1638632	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	3755548	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	HUMAN|HGNC=10484|UniProtKB=Q92736	Ryanodine receptor 2	ISS	15226293	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	PANTR|Ensembl=ENSPTRG00000019407|UniProtKB=H2QUY0	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00828	Galphai	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	RCA			PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05915	Opioid proenkephalin pathway	P05993	AC	BOVIN|Ensembl=ENSBTAG00000019210|UniProtKB=F1MJV4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00021	FGF signaling pathway	P00634	MEKK1-5	PANTR|Ensembl=ENSPTRG00000016891|UniProtKB=H2R5K3	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00036	Interleukin signaling pathway	P00985	PDK1/2	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	IDA	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00059	p53 pathway	P04609	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05916	Opioid prodynorphin pathway	P05998	Kappa Receptor	MACMU|Ensembl=ENSMMUG00000018372|UniProtKB=F7H1J2	Uncharacterized protein	ISS	11259498	PubMed	PTHR24229:SF1	KAPPA-TYPE OPIOID RECEPTOR
P00036	Interleukin signaling pathway	P00970	Interleukin	BOVIN|Ensembl=ENSBTAG00000002150|UniProtKB=Q687Y7	Interleukin-17A	IC			PTHR44866:SF1	INTERLEUKIN-17A
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00747	Rhodopsin	RAT|RGD=3573|UniProtKB=P51489	Rhodopsin	IDA	1634520	PubMed	PTHR24240:SF15	RHODOPSIN
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	HUMAN|HGNC=4584|UniProtKB=Q05586	Glutamate receptor ionotropic, NMDA 1	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00020	FAS signaling pathway	P00615	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00029	Huntington disease	P00780	Microtubule	CHICK|Ensembl=ENSGALG00000000059|UniProtKB=F1NMU4	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00010	B cell activation	P00391	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05730	Endogenous cannabinoid signaling	P05743	CB1	CANLF|Ensembl=ENSCAFG00000003085|UniProtKB=F1Q345	Uncharacterized protein	ISS	114610	OMIM	PTHR22750:SF47	CANNABINOID RECEPTOR 1
P00035	Interferon-gamma signaling pathway	P00952	Jak2	MOUSE|MGI=MGI=96629|UniProtKB=Q62120	Tyrosine-protein kinase JAK2	TAS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00005	Angiogenesis	P00231	HSP27	HUMAN|HGNC=2389|UniProtKB=P02511	Alpha-crystallin B chain	ISS			PTHR11527:SF37	ALPHA-CRYSTALLIN B CHAIN
P00047	PDGF signaling pathway	P01173	STAT	PANTR|Ensembl=ENSPTRG00000009199|UniProtKB=H2QD19	Signal transducer and activator of transcription	ISS	95236292	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	RCA	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00025	Hedgehog signaling pathway	P00699	Su(fu)	RAT|RGD=1559462|UniProtKB=Q4V8C6	Suppressor of fused homolog	ISS	10920228	PubMed	PTHR10928:SF2	SUPPRESSOR OF FUSED HOMOLOG
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CANLF|Gene=DRD2|UniProtKB=Q9GJU1	D(2) dopamine receptor	IDA	1319557	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00057	Wnt signaling pathway	P01465	Ggamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00029	Huntington disease	P00811	Arp2/3 complex	BOVIN|Ensembl=ENSBTAG00000004242|UniProtKB=Q1JP79	Actin-related protein 2/3 complex subunit 1A	ISS	12473693	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000006999|UniProtKB=E1BDQ4	Uncharacterized protein	ISS	8930069	PubMed	PTHR13715:SF15	RYANODINE RECEPTOR 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS	12606638	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04542	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00948	Rho	MACMU|Ensembl=ENSMMUG00000016040|UniProtKB=F7FMR3	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF24	RHO-RELATED GTP-BINDING PROTEIN RHOE
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	DANRE|ZFIN=ZDB-GENE-051202-2|UniProtKB=Q6ZM67	Uncharacterized protein	ISS	14698601	PubMed	PTHR44391:SF3	SUBFAMILY NOT NAMED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00036	Interleukin signaling pathway	P00981	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00018	EGF receptor signaling pathway	P00547	PP2A	MOUSE|MGI=MGI=1349473|UniProtKB=Q61151	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	ISS	10092233	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	BOVIN|Ensembl=ENSBTAG00000046248|UniProtKB=Q58CQ2	Actin-related protein 2/3 complex subunit 1B	ISS	12932731	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00021	FGF signaling pathway	P00632	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IGI	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	LEPIN|EnsemblGenome=LA_0869|UniProtKB=Q8F7S5	Aldehyde dehydrogenase	IC			PTHR43570:SF16	ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q
P00005	Angiogenesis	P00256	PLC-gamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00054	Toll receptor signaling pathway	P01355	AP1	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	12972619	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00023	General transcription regulation	P00660	RNA Polymerase II	DROME|FlyBase=FBgn0003275|UniProtKB=Q24320	DNA-directed RNA polymerases I, II, and III subunit RPABC2	ISS	717184	gi	PTHR10773:SF12	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2
P05913	Enkephalin release	P05972	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00010	B cell activation	P00402	Jnk	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00059	p53 pathway	P01486	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00010	B cell activation	P00397	IKK	MACMU|Ensembl=ENSMMUG00000018476|UniProtKB=F6X938	Uncharacterized protein	ISS	12235208	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00059	p53 pathway	G04704	KAI	HUMAN|HGNC=6210|UniProtKB=P27701	CD82 antigen	ISS			PTHR19282:SF44	CD82 ANTIGEN
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	DAPPU|EnsemblGenome=DAPPUDRAFT_301818|UniProtKB=E9I1I7	Putative uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	HUMAN|HGNC=10000|UniProtKB=P49798	Regulator of G-protein signaling 4	ISS	9774420	PubMed	PTHR10845:SF184	REGULATOR OF G-PROTEIN SIGNALING 4
P05730	Endogenous cannabinoid signaling	P05751	Galpha	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00583	cPLA2	CANLF|Ensembl=ENSCAFG00000013778|UniProtKB=F6UQ33	Phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	DROME|FlyBase=FBgn0026438|UniProtKB=E1JHQ6	Excitatory amino acid transporter 2, isoform C	ISS	94365697	PubMed	PTHR11958:SF89	EXCITATORY AMINO ACID TRANSPORTER 2, ISOFORM C
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	RAT|RGD=620436|UniProtKB=P11962	Glycoprotein hormones alpha chain	ISS	1099091	PubMed	PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	MACMU|Ensembl=ENSMMUG00000014486|UniProtKB=F7GH95	Ras-related protein Rap-1A	ISS	8576107	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	STRPU|EnsemblGenome=SPU_025182|UniProtKB=W4ZAK5	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MOUSE|MGI=MGI=95822|UniProtKB=Q01098	Glutamate receptor ionotropic, NMDA 2C	IC	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	CHICK|Ensembl=ENSGALG00000014539|UniProtKB=F1N861	Uncharacterized protein	ISS	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00021	FGF signaling pathway	P00641	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P02788	Xanthine and guanine salvage pathway	P03249	Guanine deaminase	HUMAN|HGNC=4212|UniProtKB=Q9Y2T3	Guanine deaminase	ISS	11837778	gi	PTHR11271:SF6	GUANINE DEAMINASE
P00012	Cadherin signaling pathway	P00470	F-actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g242065|UniProtKB=A7S0V7	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04393	Ras Pathway	P04560	AP1	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00036	Interleukin signaling pathway	P00996	STAT	PANTR|Ensembl=ENSPTRG00000009200|UniProtKB=H2QD20	Signal transducer and activator of transcription	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00018	EGF receptor signaling pathway	P00539	14-3-3	ORYSJ|EnsemblGenome=OS02G0580300|UniProtKB=Q6EUP4	14-3-3-like protein GF14-E	ISS	10407019	PubMed	PTHR18860:SF36	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	PANTR|Ensembl=ENSPTRG00000018082|UniProtKB=H2R2N3	Peroxisome proliferator-activated receptor delta	ISS	12356903	PubMed	PTHR24082:SF15	PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DELTA
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IGI	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IDA	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05913	Enkephalin release	G06045	preproenkephalin	DANRE|ZFIN=ZDB-GENE-030729-31|UniProtKB=A8E7S2	Uncharacterized protein	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00006	Apoptosis signaling pathway	P00274	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00056	VEGF signaling pathway	P01413	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	7937853	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00010	B cell activation	P00392	I kappa B	BOVIN|Ensembl=ENSBTAG00000016683|UniProtKB=Q8WNW7	NF kappa B inhibitor alpha (Fragment)	ISS	10811867	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	METJA|EnsemblGenome=MJ_0684|UniProtKB=Q58097	(5-formylfuran-3-yl)methyl phosphate transaminase	ISS			PTHR11751:SF439	SUBFAMILY NOT NAMED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00029	Huntington disease	P00775	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12960248	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	DANRE|ZFIN=ZDB-GENE-040426-877|UniProtKB=F1Q6Z7	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_79607|UniProtKB=C3ZHN4	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04556	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MOUSE|MGI=MGI=1933206|UniProtKB=A2AIR5	Protein Grin3a	ISS	14698601	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P02763	Peptidoglycan biosynthesis	P03092	Phospho-N-acetylmuramoyl pentapeptide transferase	GLOVI|EnsemblGenome=BAC91679|UniProtKB=Q7NEY9	Phospho-N-acetylmuramoyl-pentapeptide-transferase	ISS			PTHR22926:SF5	PHOSPHO-N-ACETYLMURAMOYL-PENTAPEPTIDE-TRANSFERASE
P02783	Tryptophan biosynthesis	P03210	Indole-3-glycerol phosphate synthase	BACSU|Gene=BSU22660|UniProtKB=P03964	Indole-3-glycerol phosphate synthase	ISS			PTHR22854:SF2	TRYPTOPHAN BIOSYNTHESIS PROTEIN TRPCF
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CAEBR|Gene=CBG02167|UniProtKB=A8WS37	Protein CBG02167	ISS	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	HUMAN|HGNC=129|UniProtKB=P68133	Actin, alpha skeletal muscle	IC	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00029	Huntington disease	P00786	ARF	HUMAN|HGNC=652|UniProtKB=P84077	ADP-ribosylation factor 1	IPI	12932731	PubMed	PTHR11711:SF234	ADP-RIBOSYLATION FACTOR 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00830	Lipoxygenase	HUMAN|HGNC=429|UniProtKB=P18054	Arachidonate 12-lipoxygenase, 12S-type	TAS	12432925	PubMed	PTHR11771:SF4	ARACHIDONATE 12-LIPOXYGENASE, 12S-TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	G04700	PAI	HUMAN|HGNC=8583|UniProtKB=P05121	Plasminogen activator inhibitor 1	ISS	189578	gi	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00006	Apoptosis signaling pathway	P00269	MAPK	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00036	Interleukin signaling pathway	P00996	STAT	MONDO|Ensembl=ENSMODG00000014836|UniProtKB=F7D2D3	Signal transducer and activator of transcription	ISS	22320921	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	TAS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00029	Huntington disease	P00786	ARF	DANRE|ZFIN=ZDB-GENE-030131-6151|UniProtKB=Q6P5M5	Novel protein similar to vertebrate ADP-ribosylation factor 4 (ARF4) (Zgc:77650)	ISS	12932731	PubMed	PTHR11711:SF308	ADP-RIBOSYLATION FACTOR 5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ARATH|TAIR=AT2G42170|UniProtKB=Q8GWA5	Actin family protein	IC	14684598	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	IC	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00015	Circadian clock system	P00505	Cry	PANTR|Ensembl=ENSPTRG00000005396|UniProtKB=H2Q6S7	Cryptochrome 1 (Photolyase-like)	ISS	14507900	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	BOVIN|Ensembl=ENSBTAG00000008059|UniProtKB=P41984	Muscarinic acetylcholine receptor M3	ISS	12181435	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00034	Integrin signalling pathway	P00942	Fyn	MONDO|Ensembl=ENSMODG00000017905|UniProtKB=F7FG65	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00005	Angiogenesis	P00244	MAPKAPK2/3	BOVIN|Ensembl=ENSBTAG00000016532|UniProtKB=Q3SYZ2	MAP kinase-activated protein kinase 3	ISS	11157753	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MOUSE|MGI=MGI=102705|UniProtKB=P63213	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00005	Angiogenesis	P00235	c-Fos	CANLF|Ensembl=ENSCAFG00000017040|UniProtKB=E2QYK5	Uncharacterized protein	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ORYSJ|EnsemblGenome=OS03G0718100|UniProtKB=Q10DV7	Actin-1	ISS	11889126	PubMed	PTHR11937:SF364	ACTIN-11
P00029	Huntington disease	P00774	Dynein complex	ORNAN|Ensembl=ENSOANG00000005733|UniProtKB=F6X0U8	Uncharacterized protein	ISS	9454836	PubMed	PTHR10676:SF314	CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	P01438	PP2A	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	88248000	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=1095414|UniProtKB=Q9R100	Cadherin-17	IDA	8120095	PubMed	PTHR44603:SF2	CADHERIN-17
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	BRAFL|Gene=BRAFLDRAFT_123893|UniProtKB=C3XQF4	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00149	Pen-2	RAT|RGD=1312037|UniProtKB=Q6QI68	Gamma-secretase subunit PEN-2	IDA	12110170	PubMed	PTHR16318:SF0	GAMMA-SECRETASE SUBUNIT PEN-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=106673|UniProtKB=P97714	Alpha-1D adrenergic receptor	IDA			PTHR24248:SF14	ALPHA-1D ADRENERGIC RECEPTOR
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05913	Enkephalin release	P05971	CREB	XENTR|Xenbase=XB-GENE-945015|UniProtKB=F6QA46	Uncharacterized protein	ISS	1354612	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	RAT|RGD=2025|UniProtKB=P68136	Actin, alpha skeletal muscle	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00054	Toll receptor signaling pathway	P01358	ERK1	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00056	VEGF signaling pathway	P01411	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00009	Axon guidance mediated by netrin	P00364	cdc42	IXOSC|EnsemblGenome=ISCW003614|UniProtKB=B7PHY7	Cdc42 protein, putative	ISS	12932731	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	DROME|FlyBase=FBgn0004509|UniProtKB=P26016	Furin-like protease 1, isoforms 1/1-X/2	IDA	10956649	PubMed	PTHR42884:SF3	FURIN-LIKE PROTEASE 1, ISOFORMS 1/1-X/2
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	MOUSE|MGI=MGI=95821|UniProtKB=Q01097	Glutamate receptor ionotropic, NMDA 2B	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00010	B cell activation	P00379	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00016	Cytoskeletal regulation by Rho GTPase	P00507	Rho	CAEEL|WormBase=WBGene00004357|UniProtKB=Q22038	Ras-like GTP-binding protein rhoA	ISS	7798239	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00059	p53 pathway	G01572	NOXA	MOUSE|MGI=MGI=1930146|UniProtKB=Q9JM54	Phorbol-12-myristate-13-acetate-induced protein 1	RCA			PTHR14299:SF0	PHORBOL-12-MYRISTATE-13-ACETATE-INDUCED PROTEIN 1
P00024	Glycolysis	P00673	Triosephosphate isomerase	RAT|RGD=3896|UniProtKB=P48500	Triosephosphate isomerase	RCA			PTHR21139:SF15	TRIOSEPHOSPHATE ISOMERASE
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IGI	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00384	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	IDA	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	DANRE|ZFIN=ZDB-GENE-000330-9|UniProtKB=Q90ZE4	Presenilin-2	IDA	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-1712|UniProtKB=Q6PBY0	Guanine nucleotide binding protein (G protein), beta 5	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00009	Axon guidance mediated by netrin	P00356	UNC-5	MOUSE|MGI=MGI=1095412|UniProtKB=O08747	Netrin receptor UNC5C	ISS			PTHR12582:SF7	NETRIN RECEPTOR UNC5C
P00019	Endothelin signaling pathway	P00590	IP3 R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01438	PP2A	IXOSC|EnsemblGenome=ISCW014549|UniProtKB=B7QGY5	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00927	Rac	DICDI|dictyBase=DDB_G0268622|UniProtKB=P34145	Rho-related protein rac1B	IGI	12932731	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00049	Parkinson disease	P01227	20S proteasome	YEAST|SGD=S000004557|UniProtKB=P23639	Proteasome subunit alpha type-2	TAS	12859888	PubMed	PTHR11599:SF16	PROTEASOME SUBUNIT ALPHA TYPE-2
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00036	Interleukin signaling pathway	P00983	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BRAFL|Gene=BRAFLDRAFT_271417|UniProtKB=C3ZCG7	Protein Wnt	TAS	11266476	PubMed	PTHR12027:SF102	PROTEIN WNT-4
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95810|UniProtKB=Q9Z2W9	Glutamate receptor 3	ISS	10331083	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00048	PI3 kinase pathway	P01177	P110ACT	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00006	Apoptosis signaling pathway	P00310	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01451	Galpha	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	IDA	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01179	PKB	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	TAS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MOUSE|MGI=MGI=95770|UniProtKB=P30678	Guanine nucleotide-binding protein subunit alpha-15	IDA	10629036	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	SYNY3|EnsemblGenome=BAA16727|UniProtKB=P72720	Glutamine--fructose-6-phosphate aminotransferase [isomerizing]	ISS			PTHR10937:SF0	GH12731P-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	TAS	9851932	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00029	Huntington disease	P00810	GAPDH	GIAIC|EnsemblGenome=GL50803_6687|UniProtKB=A8BSP4	Glyceraldehyde-3-phosphate dehydrogenase	IPI			PTHR10836:SF52	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MOUSE|MGI=MGI=96276|UniProtKB=Q61224	5-hydroxytryptamine receptor 1D	ISS	14645495	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00021	FGF signaling pathway	P00644	p38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IGI	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00011	Blood coagulation	P00408	Plasminogen	PANTR|Ensembl=ENSPTRG00000018774|UniProtKB=H2QU06	Plasminogen	ISS	130317	gi	PTHR24261:SF6	PLASMINOGEN
P00019	Endothelin signaling pathway	P00589	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01160	IP3 receptor	DROME|FlyBase=FBgn0010051|UniProtKB=P29993	Inositol 1,4,5-trisphosphate receptor	ISS	11007872	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	PANTR|Ensembl=ENSPTRG00000013428|UniProtKB=H2QK88	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF358	MYOSIN-7B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	MACMU|Ensembl=ENSMMUG00000009603|UniProtKB=F6ZQ12	DnaJ homolog subfamily C member 27 isoform 1	ISS			PTHR24073:SF269	DNAJ HOMOLOG SUBFAMILY C MEMBER 27
P00029	Huntington disease	P00790	beta-Tubulin	BOVIN|Ensembl=ENSBTAG00000021013|UniProtKB=Q3ZBU7	Tubulin beta-4A chain	ISS	12932731	PubMed	PTHR11588:SF253	TUBULIN BETA-4A CHAIN
P00047	PDGF signaling pathway	P01160	IP3 receptor	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01451	Galpha	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	IDA	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00059	p53 pathway	P04635	Sumo-1 ligase	MONDO|Ensembl=ENSMODG00000007222|UniProtKB=F6WCW3	Small ubiquitin-related modifier	ISS			PTHR10562:SF11	SMALL UBIQUITIN-RELATED MODIFIER 2-RELATED
P05730	Endogenous cannabinoid signaling	P05751	Galpha	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00052	TGF-beta signaling pathway	P01284	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00632	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000024162|UniProtKB=H2R198	Protocadherin 18	ISS	8120095	PubMed	PTHR24028:SF9	PROTOCADHERIN-18
P00036	Interleukin signaling pathway	P00996	STAT	MONDO|Ensembl=ENSMODG00000014836|UniProtKB=F7D2D3	Signal transducer and activator of transcription	ISS	96210005	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00056	VEGF signaling pathway	P01422	eNOS	RAT|RGD=3186|UniProtKB=Q62600	Nitric oxide synthase, endothelial	ISS	22462730	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00037	Ionotropic glutamate receptor pathway	P01023	CaMKII	HUMAN|HGNC=1460|UniProtKB=Q9UQM7	Calcium/calmodulin-dependent protein kinase type II subunit alpha	ISS	10092204	PubMed	PTHR43940:SF5	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00005	Angiogenesis	P00223	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02783	Tryptophan biosynthesis	P03208	Tryptophan synthase B	METJA|EnsemblGenome=MJ_1037|UniProtKB=Q60179	Tryptophan synthase beta chain	ISS			PTHR42882:SF1	TRYPTOPHAN SYNTHASE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00780	Microtubule	TAKRU|Ensembl=ENSTRUG00000005300|UniProtKB=H2SJZ5	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	YEAST|SGD=S000004354|UniProtKB=P23561	Serine/threonine-protein kinase STE11	ISS			PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00059	p53 pathway	P04609	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	RCA	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	MOUSE|MGI=MGI=88459|UniProtKB=Q04857	Collagen alpha-1(VI) chain	IDA	10778855	PubMed	PTHR44172:SF3	COLLAGEN ALPHA-1 VI  CHAIN
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	18021322	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	1718748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01279	Smurfs	BOVIN|Ensembl=ENSBTAG00000007118|UniProtKB=F1MLS5	Uncharacterized protein	ISS	11252892	PubMed	PTHR11254:SF293	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CHICK|Ensembl=ENSGALG00000015358|UniProtKB=F1NM49	Uncharacterized protein	IC	89264452	PubMed	PTHR13140:SF575	MYOSIN-15
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00006	Apoptosis signaling pathway	P00274	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	HUMAN|HGNC=235|UniProtKB=Q8NFM4	Adenylate cyclase type 4	ISS	1946437	PubMed	PTHR11920:SF286	ADENYLATE CYCLASE TYPE 4
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00015	Circadian clock system	P00506	BMAL1	RAT|RGD=62003|UniProtKB=Q9EPW1	Aryl hydrocarbon receptor nuclear translocator-like protein 1	ISS	11163178	PubMed	PTHR23042:SF52	ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00920	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000001867|UniProtKB=H2Q0X8	Adenosine receptor A1	ISS	12515326	PubMed	PTHR24246:SF1	ADENOSINE RECEPTOR A1
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05925	beta-ARR1	BOVIN|Ensembl=ENSBTAG00000020485|UniProtKB=P17870	Beta-arrestin-1	RCA	11742073	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CHICK|Ensembl=ENSGALG00000012894|UniProtKB=P30372	Muscarinic acetylcholine receptor M2	IDA	11166329	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00011	Blood coagulation	P00434	FXIa	HUMAN|HGNC=3551|UniProtKB=P00740	Coagulation factor IX	ISS	182609	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P00020	FAS signaling pathway	P00611	Gelsolin	MOUSE|MGI=MGI=1306794|UniProtKB=Q60604	Adseverin	IGI	9323209	PubMed	PTHR11977:SF78	ADSEVERIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	RAT|RGD=71027|UniProtKB=P42264	Glutamate receptor ionotropic, kainate 3	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00551	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01275	P38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00521	Profilin	HUMAN|HGNC=8881|UniProtKB=P07737	Profilin-1	ISS			PTHR13936:SF14	PROFILIN-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CAEBR|Gene=CBG23090|UniProtKB=A8Y4R0	Protein CBG23090	ISS	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00824	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	TAS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P06664	Gonadotropin-releasing hormone receptor pathway	P06834	MAP3Ks	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	RCA	8940199	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00049	Parkinson disease	P01211	ERK	HUMAN|HGNC=6880|UniProtKB=Q13164	Mitogen-activated protein kinase 7	IDA	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	IDA	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00030	Hypoxia response via HIF activation	P00819	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MOUSE|MGI=MGI=1351340|UniProtKB=Q9QYS2	Metabotropic glutamate receptor 3	IDA			PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MONDO|Ensembl=ENSMODG00000004799|UniProtKB=F6VM87	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=69279|UniProtKB=Q9R0T4	Cadherin-1	IDA	8120095	PubMed	PTHR24027:SF319	CADHERIN-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IDA	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00025	Hedgehog signaling pathway	P00691	CBP	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P02752	Mannose metabolism	P03018	Mannose 1-P guanylyl transferase	SYNY3|Gene=BAA18379|UniProtKB=P74285	Mannose-1-phosphate guanyltransferase	ISS	8905231	PubMed	PTHR22572:SF137	SUBFAMILY NOT NAMED
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	XENTR|Xenbase=XB-GENE-6050844|UniProtKB=F6WNJ9	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P02743	Formyltetrahydroformate biosynthesis	P02952	Methylene tetrahydrofolate dehydrogenase	BOVIN|Ensembl=ENSBTAG00000004881|UniProtKB=Q0P5C2	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	ISS			PTHR10025:SF39	BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, MITOCHONDRIAL
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01179	PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	ANOGA|EnsemblGenome=AGAP005913|UniProtKB=Q7Q6D2	AGAP005913-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	10218114	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00006	Apoptosis signaling pathway	P00310	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	ANOGA|EnsemblGenome=AGAP005912|UniProtKB=Q7Q6D3	AGAP005912-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00045	Notch signaling pathway	G01541	E(spl)-C genes	MOUSE|MGI=MGI=1860511|UniProtKB=Q9DBX7	Hairy/enhancer-of-split related with YRPW motif-like protein	TAS	10860664	PubMed	PTHR10985:SF79	HAIRY/ENHANCER-OF-SPLIT RELATED WITH YRPW MOTIF-LIKE PROTEIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00036	Interleukin signaling pathway	P00981	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05918	p38 MAPK pathway	P06017	MNK2	HUMAN|HGNC=7111|UniProtKB=Q9HBH9	MAP kinase-interacting serine/threonine-protein kinase 2	IDA	11463832	PubMed	PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P00037	Ionotropic glutamate receptor pathway	P01001	KA4	CHICK|Ensembl=ENSGALG00000006638|UniProtKB=R4GGL9	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00034	Integrin signalling pathway	P00916	Ras	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	IPI	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00715	AGS3	MOUSE|MGI=MGI=1923373|UniProtKB=Q8VDU0	G-protein-signaling modulator 2	IDA	11121039	PubMed	PTHR10098:SF100	G-PROTEIN-SIGNALING MODULATOR 2
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00016	Cytoskeletal regulation by Rho GTPase	P00524	LIMK	CHICK|Ensembl=ENSGALG00000001076|UniProtKB=Q8QFP8	LIM domain kinase 1	ISS			PTHR44124:SF1	LIM DOMAIN KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	94280860	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00034	Integrin signalling pathway	P00925	MEK	CANLF|Ensembl=ENSCAFG00000017851|UniProtKB=F1PBB6	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00053	T cell activation	P01307	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02723	Adenine and hypoxanthine salvage pathway	P02805	Adenine phosphorylase	PANTR|Ensembl=ENSPTRG00000006095|UniProtKB=H2Q7W4	Purine nucleoside phosphorylase	ISS			PTHR11904:SF12	PURINE NUCLEOSIDE PHOSPHORYLASE
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	XENTR|Xenbase=XB-GENE-481916|UniProtKB=F6YF14	Presenilin	ISS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00021	FGF signaling pathway	P00640	PI3K	SCHPO|PomBase=SPAC458.05|UniProtKB=P50520	Phosphatidylinositol 3-kinase vps34	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00029	Huntington disease	P00805	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01413	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	96009592	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	TAS	12719720	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04393	Ras Pathway	P04546	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IDA	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05731	GABA-B receptor II signaling	P05753	Ca channel	HUMAN|HGNC=1394|UniProtKB=O43497	Voltage-dependent T-type calcium channel subunit alpha-1G	TAS	14526084	PubMed	PTHR10037:SF137	VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1G
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	CANLF|Ensembl=ENSCAFG00000016077|UniProtKB=E2QW66	Receptor protein serine/threonine kinase	ISS	10683140	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P00007	Axon guidance mediated by semaphorins	P00340	Rac	CHICK|Ensembl=ENSGALG00000002859|UniProtKB=F6UBD2	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04374	5HT2 type receptor mediated signaling pathway	P04413	K+ channel	HUMAN|HGNC=6278|UniProtKB=O14649	Potassium channel subfamily K member 3	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P05916	Opioid prodynorphin pathway	P06002	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00023	General transcription regulation	P00662	TFIIA complex	PANTR|Ensembl=ENSPTRG00000006596|UniProtKB=H2Q8Q5	General transcription factor IIA, 1, 19/37kDa	ISS	600519	OMIM	PTHR12694:SF7	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1
P00029	Huntington disease	P00797	p53	MOUSE|MGI=MGI=1336991|UniProtKB=Q9JJP2	Tumor protein p73	TAS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P05917	Opioid proopiomelanocortin pathway	P06004	Mu or Delta receptor	HUMAN|HGNC=8153|UniProtKB=P41143	Delta-type opioid receptor	RCA	12093103	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-990415-257|UniProtKB=O42376	Mitogen-activated protein kinase 12	IDA	10851062	PubMed	PTHR24055:SF339	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00005	Angiogenesis	P00256	PLC-gamma	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00034	Integrin signalling pathway	P00948	Rho	HUMAN|HGNC=667|UniProtKB=P61586	Transforming protein RhoA	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00648	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	IGI	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00053	T cell activation	P01318	PKC-theta	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IC	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	ANOGA|EnsemblGenome=AGAP002578|UniProtKB=F5HKU8	AGAP002578-PB	ISS	8386525	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P00059	p53 pathway	P04633	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06959	CCKR signaling map	P07127	Adenylate cyclase	HUMAN|HGNC=232|UniProtKB=Q08828	Adenylate cyclase type 1	RCA	11264454	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P00012	Cadherin signaling pathway	P00470	F-actin	RAT|RGD=1304556|UniProtKB=P63259	Actin, cytoplasmic 2	ISS	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00029	Huntington disease	P00811	Arp2/3 complex	CANLF|Ensembl=ENSCAFG00000015081|UniProtKB=E2RMT4	Uncharacterized protein	ISS	12932731	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00059	p53 pathway	P04633	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01465	Ggamma	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00019	Endothelin signaling pathway	P00590	IP3 R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00009	Axon guidance mediated by netrin	P00366	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	CAEEL|WormBase=WBGene00001680|UniProtKB=Q20636	Guanine nucleotide-binding protein subunit beta-2	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	10395542	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00030	Hypoxia response via HIF activation	P00819	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	MACMU|Ensembl=ENSMMUG00000006200|UniProtKB=F7HNS7	Receptor protein serine/threonine kinase	ISS			PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P04393	Ras Pathway	P04557	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	IDA	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00221	JNK1	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00053	T cell activation	P01311	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	IEA	12411479	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00007	Axon guidance mediated by semaphorins	P00340	Rac	MACMU|Ensembl=ENSMMUG00000021075|UniProtKB=F7GY91	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00053	T cell activation	P01322	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	ISS	10974003	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00052	TGF-beta signaling pathway	P01284	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	ORNAN|Ensembl=ENSOANG00000015652|UniProtKB=F7FY70	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	CAEEL|WormBase=WBGene00004776|UniProtKB=O17470	SERotonin/octopamine receptor family	ISS	11859080	PubMed	PTHR24247:SF125	5-HYDROXYTRYPTAMINE  SEROTONIN  RECEPTOR 2A, ISOFORM B
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	PANTR|Ensembl=ENSPTRG00000007536|UniProtKB=H2QA71	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF144	REGULATOR OF G-PROTEIN SIGNALING 11
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT1G59580|UniProtKB=Q39022	Mitogen-activated protein kinase 2	ISS	11707292	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00059	p53 pathway	P04629	PCAF	CHICK|Ensembl=ENSGALG00000011278|UniProtKB=F1P124	Uncharacterized protein	ISS			PTHR22880:SF116	HISTONE ACETYLTRANSFERASE KAT2B
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=17175|UniProtKB=Q9P212	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	15611108	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06738	PLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	RCA	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00018	EGF receptor signaling pathway	P00547	PP2A	BOVIN|Ensembl=ENSBTAG00000005533|UniProtKB=F1N1S8	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	PANTR|Ensembl=ENSPTRG00000020930|UniProtKB=H2QX95	Uncharacterized protein	ISS	11889126	PubMed	PTHR10639:SF1	CLATHRIN LIGHT CHAIN A
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	RCA	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00047	PDGF signaling pathway	P01150	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04395	Vasopressin synthesis	P04597	Signal Peptide	PANTR|Ensembl=ENSPTRG00000013189|UniProtKB=H2QJV1	Uncharacterized protein	ISS	3768139	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00053	T cell activation	P01305	Calmodulin	ORYSJ|EnsemblGenome=OS01G0267900|UniProtKB=Q0JNS6	Calmodulin-1	ISS	7514101	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00811	Arp2/3 complex	PANTR|Ensembl=ENSPTRG00000033819|UniProtKB=H2QV00	Actin related protein 2/3 complex, subunit 1A, 41kDa	ISS	12473693	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000015178|UniProtKB=F6WI86	Neural cadherin	ISS	13678586	PubMed	PTHR24027:SF79	CADHERIN-2
P00010	B cell activation	P00385	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00058	mRNA splicing	P01476	U4	MONDO|Ensembl=ENSMODG00000018774|UniProtKB=F7ADZ9	Uncharacterized protein	ISS	9328476	PubMed	PTHR14212:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DROME|FlyBase=FBgn0259680|UniProtKB=P83099	Putative protein kinase C delta type homolog	ISS	3045562	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04409	5HT transporter	CANLF|Ensembl=ENSCAFG00000018990|UniProtKB=F1PXA1	Transporter	ISS	7681602	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00046	Oxidative stress response	P01125	Stat1	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	14755057	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	BRAFL|Gene=BRAFLDRAFT_122664|UniProtKB=C3ZIB9	Putative uncharacterized protein	ISS	4757952	gi	PTHR24072:SF192	CDC42 HOMOLOG
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	CAEEL|WormBase=WBGene00002335|UniProtKB=P22981	Ras protein let-60	ISS	12024031	PubMed	PTHR24070:SF385	GTPASE HRAS
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05918	p38 MAPK pathway	P06031	p38alpha	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00048	PI3 kinase pathway	P01189	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00021	FGF signaling pathway	P00648	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00048	PI3 kinase pathway	P01182	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00014	Cholesterol biosynthesis	P00494	Squalene monooxygenas	ARATH|TAIR=AT5G24160|UniProtKB=O65402	Squalene epoxidase 6	ISS			PTHR10835:SF1	SQUALENE EPOXIDASE 4-RELATED
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=1352756|UniProtKB=Q8K394	Inactive phospholipase C-like protein 2	TAS			PTHR10336:SF84	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2
P00054	Toll receptor signaling pathway	P01357	MEKK1	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	ISS	12049732	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	RAT|RGD=70919|UniProtKB=P08081	Clathrin light chain A	ISS	9388255	PubMed	PTHR10639:SF1	CLATHRIN LIGHT CHAIN A
P00034	Integrin signalling pathway	P00936	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00552	Ras	PANTR|Ensembl=ENSPTRG00000015445|UniProtKB=H2QNG3	Muscle RAS oncogene homolog	ISS			PTHR24070:SF268	RAS-RELATED PROTEIN M-RAS
P00011	Blood coagulation	P00434	FXIa	MACMU|Ensembl=ENSMMUG00000020064|UniProtKB=F7GHR4	Uncharacterized protein	ISS	182609	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IGI	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00034	Integrin signalling pathway	P00907	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CAEEL|WormBase=WBGene00004036|UniProtKB=G5EFI8	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	XENTR|Xenbase=XB-GENE-480379|UniProtKB=Q6GL20	Frizzled homolog 10	ISS	11212302	PubMed	PTHR11309:SF86	FRIZZLED-10
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	ARATH|TAIR=AT5G61210|UniProtKB=Q9S7P9	SNAP25 homologous protein SNAP33	IC			PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	ANOGA|EnsemblGenome=AGAP001478|UniProtKB=Q7PXM3	AGAP001478-PA	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00006	Apoptosis signaling pathway	P00274	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	RAT|RGD=3645|UniProtKB=P14844	C-C motif chemokine 2	ISS			PTHR12015:SF117	C-C MOTIF CHEMOKINE 2
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00049	Parkinson disease	P01237	Complex I	CAEEL|WormBase=WBGene00009992|UniProtKB=Q20719	Probable NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	TAS	3100899	PubMed	PTHR10371:SF3	NADH DEHYDROGENASE  UBIQUINONE  FLAVOPROTEIN 2, MITOCHONDRIAL
P00029	Huntington disease	P00770	N-CoR	RAT|RGD=1310293|UniProtKB=D3ZXN9	Nuclear receptor co-repressor 2 (Predicted), isoform CRA_a	ISS	10441327	PubMed	PTHR13992:SF21	NUCLEAR RECEPTOR COREPRESSOR 2
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	94280860	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IPI	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04570	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02729	Ascorbate degradation	P02849	L-xylulose kinase	ECOLI|EcoGene=EG12284|UniProtKB=P37677	L-xylulose/3-keto-L-gulonate kinase	ISS			PTHR43095:SF3	L-XYLULOSE/3-KETO-L-GULONATE KINASE
P00059	p53 pathway	P04626	GADD45	MOUSE|MGI=MGI=107776|UniProtKB=P22339	Growth arrest and DNA damage-inducible protein GADD45 beta	IGI	10097101	PubMed	PTHR10411:SF5	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 BETA
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ORYSJ|EnsemblGenome=OS03G0285800|UniProtKB=Q10N20	Mitogen-activated protein kinase 5	ISS	12787066	PubMed	PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00048	PI3 kinase pathway	P01202	p85	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00059	p53 pathway	G04691	IGF-BP3	HUMAN|HGNC=5472|UniProtKB=P17936	Insulin-like growth factor-binding protein 3	ISS			PTHR11551:SF3	INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 3
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	HUMAN|HGNC=26526|UniProtKB=Q96MA6	Adenylate kinase 8	ISS			PTHR23359:SF102	ADENYLATE KINASE 8
P00057	Wnt signaling pathway	P01455	Smad4	MONDO|Ensembl=ENSMODG00000010995|UniProtKB=F7A1M2	Mothers against decapentaplegic homolog	ISS	10693808	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P00010	B cell activation	P00379	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	IDA	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00054	Toll receptor signaling pathway	P01380	TLR1,2,6	MOUSE|MGI=MGI=1341296|UniProtKB=Q9EPW9	Toll-like receptor 6	ISS			PTHR24365:SF422	TOLL-LIKE RECEPTOR 6
P00045	Notch signaling pathway	P01115	Neurotic	PANTR|Ensembl=ENSPTRG00000013375|UniProtKB=Q6EV69	GDP-fucose protein O-fucosyltransferase 1	RCA			PTHR21420:SF3	GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DICDI|dictyBase=DDB_G0289487|UniProtKB=P07829	Actin-3	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00054	Toll receptor signaling pathway	P01358	ERK1	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	ISS	15313841	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04393	Ras Pathway	P04567	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	TAKRU|Ensembl=ENSTRUG00000011169|UniProtKB=H2TU36	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01199	Galpha	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MOUSE|MGI=MGI=1933206|UniProtKB=A2AIR5	Protein Grin3a	ISS	11554549	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00004	Alzheimer disease-presenilin pathway	P00117	E-cadherin C-terminal fragment	HUMAN|HGNC=1762|UniProtKB=P22223	Cadherin-3	IDA	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04393	Ras Pathway	P04570	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=99403|UniProtKB=Q60614	Adenosine receptor A2b	IDA			PTHR24246:SF18	ADENOSINE RECEPTOR A2B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	HUMAN|HGNC=9998|UniProtKB=P41220	Regulator of G-protein signaling 2	ISS	8756726	PubMed	PTHR10845:SF43	REGULATOR OF G-PROTEIN SIGNALING 2
P00057	Wnt signaling pathway	P01440	Cadherin	BOVIN|Ensembl=ENSBTAG00000020657|UniProtKB=E1BKL9	Uncharacterized protein	ISS	8120095	PubMed	PTHR24026:SF42	PROTOCADHERIN FAT 1
P00021	FGF signaling pathway	P00623	FGF	MONDO|Ensembl=ENSMODG00000006480|UniProtKB=F7F2X9	Fibroblast growth factor	ISS	11927601	PubMed	PTHR11486:SF4	FIBROBLAST GROWTH FACTOR 18
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04398	p53 pathway feedback loops 2	P04668	p53	MACMU|Ensembl=ENSMMUG00000016569|UniProtKB=F6VXE7	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00030	Hypoxia response via HIF activation	P00820	HIF-1beta	HUMAN|HGNC=700|UniProtKB=P27540	Aryl hydrocarbon receptor nuclear translocator	ISS	7836384	PubMed	PTHR23042:SF50	ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000003399|UniProtKB=H2Q383	Phosphoinositide-3-kinase, class 2, alpha polypeptide	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	RAT|RGD=2739|UniProtKB=Q00961	Glutamate receptor ionotropic, NMDA 2C	ISS	14698601	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00006	Apoptosis signaling pathway	P00269	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05731	GABA-B receptor II signaling	P05754	Ggamma	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	RCA	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CANLF|Ensembl=ENSCAFG00000012623|UniProtKB=F1PVP1	Uncharacterized protein	ISS	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=1561991|UniProtKB=A0A096MJW8	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF51	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-1
P00050	Plasminogen activating cascade	P01254	pro-MMP-13	BOVIN|Gene=MMP13|UniProtKB=O77656	Collagenase 3	ISS	12834808	PubMed	PTHR10201:SF165	COLLAGENASE 3
P04393	Ras Pathway	P04552	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00018	EGF receptor signaling pathway	P00545	JNK1-3	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	LEIMA|EnsemblGenome=LmjF.18.1080|UniProtKB=Q27687	Protein kinase A catalytic subunit	IC	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=103077|UniProtKB=Q64704	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IDA	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00029	Huntington disease	P00811	Arp2/3 complex	MOUSE|MGI=MGI=1343142|UniProtKB=Q9WV32	Actin-related protein 2/3 complex subunit 1B	TAS	12932731	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00021	FGF signaling pathway	P00629	PP2A	HUMAN|HGNC=9300|UniProtKB=P62714	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	IDA	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00054	Toll receptor signaling pathway	P01375	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00010	B cell activation	P00385	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P05915	Opioid proenkephalin pathway	P05994	G-protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00047	PDGF signaling pathway	P01157	MAPKAPK2	MOUSE|MGI=MGI=109298|UniProtKB=P49138	MAP kinase-activated protein kinase 2	ISS	8262198	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Ensembl=ENSBTAG00000007642|UniProtKB=Q0VC81	Adenosine receptor A3	ISS	12515326	PubMed	PTHR24246:SF2	ADENOSINE RECEPTOR A3
P02747	Histidine biosynthesis	P02992	Imidazol glycerol phosphate synthase	YEAST|SGD=S000000452|UniProtKB=P33734	Imidazole glycerol phosphate synthase hisHF	ISS			PTHR21235:SF2	IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF
P00019	Endothelin signaling pathway	P00566	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	P04626	GADD45	BOVIN|Ensembl=ENSBTAG00000013860|UniProtKB=Q3ZBN6	Growth arrest and DNA damage-inducible protein GADD45 alpha	ISS	9827804	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P00019	Endothelin signaling pathway	P00568	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04393	Ras Pathway	P04569	Cdc42	CAEBR|Gene=CBG13013|UniProtKB=A8XGW3	Protein CBR-CDC-42	ISS	12932731	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00021	FGF signaling pathway	P00625	MKK3,6	CANLF|Ensembl=ENSCAFG00000018530|UniProtKB=F1PXD3	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00029	Huntington disease	P00805	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Ensembl=ENSPTRG00000000543|UniProtKB=H2PYN8	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00029	Huntington disease	P00761	Truncated Htt	MACMU|Ensembl=ENSMMUG00000008392|UniProtKB=F6VQZ3	Uncharacterized protein	ISS	8268927	PubMed	PTHR10170:SF10	HUNTINGTIN
P00011	Blood coagulation	P00429	PN2	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	ISS	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00021	FGF signaling pathway	P00643	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01294	NFAT	MACMU|Ensembl=ENSMMUG00000003370|UniProtKB=F7E8G2	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	PANTR|Ensembl=ENSPTRG00000024078|UniProtKB=H2R3T0	Insulin-like growth factor 1 (Somatomedin C)	ISS			PTHR11454:SF4	INSULIN-LIKE GROWTH FACTOR I
P00045	Notch signaling pathway	P01108	Nicastrin	ARATH|TAIR=AT3G52640|UniProtKB=Q8GUM5	Nicastrin	TAS	16096062	PubMed	PTHR21092:SF0	NICASTRIN
P04397	p53 pathway by glucose deprivation	P04641	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02742	Tetrahydrofolate biosynthesis	P02945	Dihydropteroate synthase	DEIRA|EnsemblGenome=DR_0168|UniProtKB=Q9RXY6	Dihydropteroate synthase	ISS			PTHR20941:SF1	FOLIC ACID SYNTHESIS PROTEIN FOL1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00034	Integrin signalling pathway	P00941	Integrin alpha	MACMU|Ensembl=ENSMMUG00000004026|UniProtKB=F7GNK9	Uncharacterized protein	ISS	3487386	PubMed	PTHR23220:SF21	INTEGRIN ALPHA-11
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	MACMU|Ensembl=ENSMMUG00000023790|UniProtKB=F7HT93	Protein-serine/threonine kinase	RCA			PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P00010	B cell activation	P00384	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	BOVIN|Ensembl=ENSBTAG00000006101|UniProtKB=Q58DA0	26S proteasome non-ATPase regulatory subunit 4	ISS	11827521	PubMed	PTHR10223:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CAEEL|WormBase=WBGene00003186|UniProtKB=Q10664	Dual specificity mitogen-activated protein kinase kinase mek-2	IGI	17508425	gi	PTHR24361:SF629	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1
P00059	p53 pathway	G04694	p110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06011	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	MONDO|Ensembl=ENSMODG00000018237|UniProtKB=F6PG65	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00021	FGF signaling pathway	P00642	MEK1-2	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05913	Enkephalin release	P05977	G-Protein (s)	ORNAN|Ensembl=ENSOANG00000013961|UniProtKB=F6VPY1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04495	TSC1	HUMAN|HGNC=12362|UniProtKB=Q92574	Hamartin	IDA	12820960	PubMed	PTHR15154:SF2	HAMARTIN
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00774	Dynein complex	BOVIN|Ensembl=ENSBTAG00000045756|UniProtKB=G3MX54	Uncharacterized protein	ISS	9454836	PubMed	PTHR11886:SF52	DYNEIN LIGHT CHAIN 1, CYTOPLASMIC
P02740	De novo pyrimidine ribonucleotides biosythesis	P02927	Dihydrooratate oxidase	SULSO|EnsemblGenome=SSO0610|UniProtKB=Q9UX04	Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit	ISS			PTHR43843:SF1	DIHYDROOROTATE DEHYDROGENASE  FUMARATE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IC	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00012	Cadherin signaling pathway	P00465	TCF/LEF	CHICK|Ensembl=ENSGALG00000010529|UniProtKB=O93345	Lymphiod enhancer binding factor 1	ISS	11266476	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00053	T cell activation	P01312	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00020	FAS signaling pathway	P00601	c-Jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS			PTHR13808:SF5	CREB-BINDING PROTEIN
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=17175|UniProtKB=Q9P212	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	7822322	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P05913	Enkephalin release	P05977	G-Protein (s)	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00034	Integrin signalling pathway	P00922	Collagen	MACMU|Ensembl=ENSMMUG00000007205|UniProtKB=F7EL16	Uncharacterized protein	ISS	10778855	PubMed	PTHR24023:SF533	COLLAGEN ALPHA-6 IV  CHAIN
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00004	Alzheimer disease-presenilin pathway	P00125	Ire-1 C-terminal fragment	SCHPO|PomBase=SPAC167.01|UniProtKB=O94537	Serine/threonine-protein kinase ppk4	IDA	10619423	PubMed	PTHR13954:SF6	INOSITOL-REQUIRING ENZYME-1
P00016	Cytoskeletal regulation by Rho GTPase	P00507	Rho	BOVIN|Ensembl=ENSBTAG00000014299|UniProtKB=Q1RMJ6	Rho-related GTP-binding protein RhoC	ISS	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00009	Axon guidance mediated by netrin	P00363	PI3K	XENTR|Xenbase=XB-GENE-6067221|UniProtKB=F6Z0J4	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00017	DNA replication	P00527	Histones	MONBE|Gene=20088|UniProtKB=A9UTW8	Histone H3	ISS	20448842	PubMed	PTHR11426:SF169	HISTONE H3
P00030	Hypoxia response via HIF activation	P00819	AKT	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	TAS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00020	FAS signaling pathway	P00604	Pro-Caspase8	HUMAN|HGNC=1876|UniProtKB=O15519	CASP8 and FADD-like apoptosis regulator	IGI			PTHR10454:SF8	CASP8 AND FADD-LIKE APOPTOSIS REGULATOR
P00047	PDGF signaling pathway	P01154	Ras	DAPPU|EnsemblGenome=DAPPUDRAFT_301818|UniProtKB=E9I1I7	Putative uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DROME|FlyBase=FBgn0010333|UniProtKB=P40792	Ras-related protein Rac1	ISS	12932731	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00012	Cadherin signaling pathway	P00474	Wnt	CAEBR|Gene=CBG06978|UniProtKB=A8X402	Protein CBR-CWN-1	ISS	8717036	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02750	Lipoate_biosynthesis	P03004	Lipoate synthase	HALSA|EnsemblGenome=VNG_2216G|UniProtKB=Q9HN78	Probable lipoyl synthase	ISS			PTHR10949:SF0	LIPOYL SYNTHASE, MITOCHONDRIAL
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	15210700	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	TRYB2|Gene=Tb11.01.7800|UniProtKB=Q381H3	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00585	ECE1-3	CAEEL|WormBase=WBGene00017554|UniProtKB=O16789	NEPrilysin metallopeptidase family	ISS			PTHR11733:SF7	NEPRILYSIN METALLOPEPTIDASE FAMILY
P02746	Heme biosynthesis	P02979	porphobilinogen synthase	ANOGA|EnsemblGenome=AGAP010935|UniProtKB=Q7QGX8	Delta-aminolevulinic acid dehydratase	ISS			PTHR11458:SF0	DELTA-AMINOLEVULINIC ACID DEHYDRATASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00021	FGF signaling pathway	P00645	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	15470041	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00008	Axon guidance mediated by Slit/Robo	P00348	Robo	DANRE|ZFIN=ZDB-GENE-001019-1|UniProtKB=F1QEH0	Uncharacterized protein	ISS			PTHR44096:SF2	ROUNDABOUT HOMOLOG 2
P00012	Cadherin signaling pathway	P00462	Casein kinase II	DANRE|ZFIN=ZDB-GENE-990415-28|UniProtKB=Q7ZU33	Ck2a2 protein	ISS	10806215	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00047	PDGF signaling pathway	P01168	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00047	PDGF signaling pathway	P01161	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00036	Interleukin signaling pathway	P00983	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ORYSJ|EnsemblGenome=OS03G0836000|UniProtKB=Q10AZ4	Actin-3	IDA	14684598	PubMed	PTHR11937:SF254	ACTIN-1-RELATED
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IGI	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04578	Rho	MONDO|Ensembl=ENSMODG00000012981|UniProtKB=F7CS91	Uncharacterized protein	ISS	11360179	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P05918	p38 MAPK pathway	P06029	p38beta	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	MOUSE|MGI=MGI=894297|UniProtKB=O08585	Clathrin light chain A	ISS	11889126	PubMed	PTHR10639:SF1	CLATHRIN LIGHT CHAIN A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	MONDO|Ensembl=ENSMODG00000020981|UniProtKB=F6S570	Uncharacterized protein	ISS	12374786	PubMed	PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P00059	p53 pathway	P01486	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00060	Ubiquitin proteasome pathway	P01492	E1	SCHPO|PomBase=SPBC1604.21c|UniProtKB=O94609	Ubiquitin-activating enzyme E1 1	ISS			PTHR10953:SF4	GH24511P
P04398	p53 pathway feedback loops 2	G04709	MDM-2	PANTR|Ensembl=ENSPTRG00000001889|UniProtKB=H2R875	Mdm4 p53 binding protein homolog	ISS			PTHR13844:SF20	PROTEIN MDM4
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ORNAN|Ensembl=ENSOANG00000007405|UniProtKB=F7CIV4	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	RAT|RGD=1311985|UniProtKB=B2GV73	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	BOVIN|Ensembl=ENSBTAG00000011579|UniProtKB=F1N5C5	Muscarinic acetylcholine receptor	ISS	10069496	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P04397	p53 pathway by glucose deprivation	P04641	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00236	PI3K	CAEEL|WormBase=WBGene00009552|UniProtKB=G5EDY0	Phosphatidylinositol 3-kinase piki-1	ISS			PTHR10048:SF64	LD28067P
P00047	PDGF signaling pathway	P01159	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00006	Apoptosis signaling pathway	P00269	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05917	Opioid proopiomelanocortin pathway	P06007	alpha-MSH	MOUSE|MGI=MGI=97742|UniProtKB=P01193	Pro-opiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00053	T cell activation	P01336	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	CANLF|Ensembl=ENSCAFG00000013067|UniProtKB=E2RJA0	Uncharacterized protein	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00251	cPLA2	BOVIN|Ensembl=ENSBTAG00000013298|UniProtKB=A4IFJ5	Cytosolic phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00034	Integrin signalling pathway	P00925	MEK	PANTR|Ensembl=ENSPTRG00000008783|UniProtKB=H2QCA7	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	ECOLI|EcoGene=EG10372|UniProtKB=P00370	NADP-specific glutamate dehydrogenase	ISS			PTHR43571:SF1	NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	CAEEL|WormBase=WBGene00006932|UniProtKB=Q9TXI7	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00018	EGF receptor signaling pathway	P00559	MEK1-2	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	RAT|RGD=70958|UniProtKB=P19492	Glutamate receptor 3	ISS	12871085	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00019	Endothelin signaling pathway	P00589	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01422	eNOS	CANLF|Gene=NOS3|UniProtKB=Q9TUX8	Nitric oxide synthase, endothelial	ISS	22462730	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00048	PI3 kinase pathway	P01177	P110ACT	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	RAT|RGD=2740|UniProtKB=Q62645	Glutamate receptor ionotropic, NMDA 2D	ISS	11554549	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P05918	p38 MAPK pathway	P06044	GADD45	BOVIN|Ensembl=ENSBTAG00000013860|UniProtKB=Q3ZBN6	Growth arrest and DNA damage-inducible protein GADD45 alpha	ISS	10097101	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P00046	Oxidative stress response	P01135	p38	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00006	Apoptosis signaling pathway	P00269	MAPK	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01322	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00048	PI3 kinase pathway	P01199	Galpha	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS			PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	CANLF|Ensembl=ENSCAFG00000018253|UniProtKB=E2RIV3	Serine hydroxymethyltransferase	ISS			PTHR11680:SF21	SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC
P00030	Hypoxia response via HIF activation	P00819	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	DANRE|ZFIN=ZDB-GENE-980526-167|UniProtKB=P09015	Homeobox protein engrailed-2a	IEP	12356903	PubMed	PTHR24341:SF4	HOMEOBOX PROTEIN ENGRAILED-1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00049	Parkinson disease	P01227	20S proteasome	MOUSE|MGI=MGI=1096380|UniProtKB=O35955	Proteasome subunit beta type-10	TAS	12859888	PubMed	PTHR11599:SF41	PROTEASOME SUBUNIT BETA TYPE-10
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	CANLF|Ensembl=ENSCAFG00000028654|UniProtKB=J9P702	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00021	FGF signaling pathway	P00637	MKK4,7	MACMU|Ensembl=ENSMMUG00000019842|UniProtKB=F7FU91	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	PLAF7|EnsemblGenome=PF11_0377|UniProtKB=Q8IHZ9	Casein kinase I	IDA	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	IDA	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00054	Toll receptor signaling pathway	P01358	ERK1	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00059	p53 pathway	G01568	KILLER/DR5	MOUSE|MGI=MGI=1341090|UniProtKB=Q9QZM4	Tumor necrosis factor receptor superfamily member 10B	IGI	11498783	PubMed	PTHR23097:SF143	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10C-RELATED
P00029	Huntington disease	P00805	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00570	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00739	AGS3	MOUSE|MGI=MGI=1923373|UniProtKB=Q8VDU0	G-protein-signaling modulator 2	IDA	11121039	PubMed	PTHR10098:SF100	G-PROTEIN-SIGNALING MODULATOR 2
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	TAKRU|Ensembl=ENSTRUG00000016954|UniProtKB=H2V2J5	Uncharacterized protein	ISS	15858232	PubMed	PTHR13715:SF99	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS			PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00018	EGF receptor signaling pathway	P00545	JNK1-3	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01465	Ggamma	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00507	Rho	HUMAN|HGNC=669|UniProtKB=P08134	Rho-related GTP-binding protein RhoC	ISS	12090470	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01171	PLCgamma	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00034	Integrin signalling pathway	P00941	Integrin alpha	CANLF|Ensembl=ENSCAFG00000004656|UniProtKB=F1PVR1	Uncharacterized protein	ISS	3487386	PubMed	PTHR23220:SF5	INTEGRIN ALPHA-8
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04393	Ras Pathway	P04558	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	IDA	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00053	T cell activation	P01331	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IDA	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00029	Huntington disease	P00807	Actin	MOUSE|MGI=MGI=87906|UniProtKB=P63260	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00046	Oxidative stress response	P01136	Elk-1	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	11279280	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00010	B cell activation	P00402	Jnk	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02783	Tryptophan biosynthesis	P03209	Anthranilate phosphoribosyl transferase	ARATH|TAIR=AT1G25220|UniProtKB=Q42565	Anthranilate synthase beta subunit 1, chloroplastic	ISS			PTHR43418:SF6	ANTHRANILATE SYNTHASE BETA SUBUNIT-RELATED
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	HUMAN|HGNC=1389|UniProtKB=Q00975	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	8386525	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P02767	Phenylpropionate degradation	P03106	4-Hydroxy-2-ketovalerate aldolase	ECOLI|EcoGene=EG13292|UniProtKB=P51020	4-hydroxy-2-oxovalerate aldolase	ISS			PTHR10277:SF3	4-HYDROXY-2-OXOVALERATE ALDOLASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000004742|UniProtKB=H2Q5K1	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P00052	TGF-beta signaling pathway	P01284	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04393	Ras Pathway	P04556	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IDA	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00029	Huntington disease	P00790	beta-Tubulin	PUCGT|EnsemblGenome=PGTG_12204|UniProtKB=E3KPL3	Tubulin beta chain	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00029	Huntington disease	P00797	p53	DANRE|ZFIN=ZDB-GENE-990415-270|UniProtKB=P79734	Cellular tumor antigen p53	ISS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00005	Angiogenesis	P00206	Wnt	CANLF|Ensembl=ENSCAFG00000014987|UniProtKB=E2RH98	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00750	Rhodopsin kinase	CAEEL|WormBase=WBGene00001709|UniProtKB=Q09639	G protein-coupled receptor kinase 2	ISS			PTHR24355:SF18	PROTEIN-SERINE/THREONINE KINASE
P00037	Ionotropic glutamate receptor pathway	P01015	Glu4	MOUSE|MGI=MGI=95811|UniProtKB=Q9Z2W8	Glutamate receptor 4	ISS	10331083	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	YEAST|SGD=S000000438|UniProtKB=P38328	Actin-related protein 2/3 complex subunit 1	ISS	12932731	PubMed	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P00010	B cell activation	P00383	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00638	PLCgamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00059	p53 pathway	G01563	MDM-2	CANLF|Ensembl=ENSCAFG00000009669|UniProtKB=E2RDT3	Uncharacterized protein	ISS			PTHR13844:SF20	PROTEIN MDM4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CANLF|Ensembl=ENSCAFG00000012623|UniProtKB=F1PVP1	Uncharacterized protein	ISS	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	CANLF|Ensembl=ENSCAFG00000012353|UniProtKB=E2RSE6	Uncharacterized protein	ISS	95328031	PubMed	PTHR42884:SF1	FURIN
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	IDA	9851932	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	RAT|RGD=619966|UniProtKB=F1LQT1	Adenylate cyclase 7	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	DROME|FlyBase=FBgn0263116|UniProtKB=P28286	5-hydroxytryptamine receptor 2B	ISS	12441358	PubMed	PTHR24247:SF117	5-HYDROXYTRYPTAMINE RECEPTOR 2A-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	BOVIN|Ensembl=ENSBTAG00000024507|UniProtKB=E1BNF2	Uncharacterized protein	ISS	12374786	PubMed	PTHR11767:SF17	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	ANOGA|EnsemblGenome=AGAP010957|UniProtKB=Q7QGY7	AGAP010957-PA (Fragment)	ISS	9753452	PubMed	PTHR23050:SF245	AT16150P-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	SCHPO|PomBase=SPBC32H8.07|UniProtKB=Q10282	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	PANTR|Ensembl=ENSPTRG00000002706|UniProtKB=H2Q272	Receptor protein serine/threonine kinase	ISS			PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P02729	Ascorbate degradation	P02852	L-xylulose-5-phosphate-3-epimerase	CHICK|Ensembl=ENSGALG00000002847|UniProtKB=F1NT24	Uncharacterized protein	ISS			PTHR11749:SF3	RIBULOSE-PHOSPHATE 3-EPIMERASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P02727	Androgen/estrogene/progesterone biosynthesis	P02826	Estradiol 17beta-dehydrogenase	RAT|RGD=621803|UniProtKB=Q62730	Estradiol 17-beta-dehydrogenase 2	RCA			PTHR43313:SF3	ESTRADIOL 17-BETA-DEHYDROGENASE 2
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	DEIRA|EnsemblGenome=DR_2033|UniProtKB=Q9RSU0	Glutamine synthase	ISS			PTHR42974:SF1	TYPE-3 GLUTAMINE SYNTHETASE
P00040	Metabotropic glutamate receptor group II pathway	P01052	AC	HUMAN|HGNC=21285|UniProtKB=Q96PN6	Adenylate cyclase type 10	ISS	10915626	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00236	PI3K	ANOGA|EnsemblGenome=AGAP011036|UniProtKB=A0NBA9	AGAP011036-PA (Fragment)	ISS			PTHR10048:SF64	LD28067P
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	DANRE|ZFIN=ZDB-GENE-051202-1|UniProtKB=E7F101	Uncharacterized protein	ISS	92049750	PubMed	PTHR44391:SF2	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00896	Insulin IGF	DANRE|ZFIN=ZDB-GENE-980526-110|UniProtKB=O73727	Insulin	ISS			PTHR11454:SF9	INSULIN-RELATED
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P06664	Gonadotropin-releasing hormone receptor pathway	G06893	Nur77	MOUSE|MGI=MGI=1352454|UniProtKB=P12813	Nuclear receptor subfamily 4 group A member 1	RCA			PTHR24085:SF1	NUCLEAR RECEPTOR SUBFAMILY 4 GROUP A MEMBER 1
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01242	Casein kinase I	PANTR|Ensembl=ENSPTRG00000017182|UniProtKB=H2RAT8	Casein kinase 1, gamma 3	ISS	11437445	PubMed	PTHR11909:SF151	CASEIN KINASE I ISOFORM GAMMA-3
P00008	Axon guidance mediated by Slit/Robo	P00342	Slit	MACMU|Ensembl=ENSMMUG00000010428|UniProtKB=F7CX22	Uncharacterized protein	ISS	10102268	PubMed	PTHR24373:SF39	SLIT HOMOLOG 1 PROTEIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	RAT|RGD=620631|UniProtKB=Q91ZY1	Histamine H4 receptor	IDA			PTHR44152:SF1	HISTAMINE H4 RECEPTOR
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00059	p53 pathway	P01486	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00144	Ire-1	YEAST|SGD=S000001121|UniProtKB=P32361	Serine/threonine-protein kinase/endoribonuclease IRE1	IDA	10619423	PubMed	PTHR13954:SF6	INOSITOL-REQUIRING ENZYME-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00019	Endothelin signaling pathway	P00585	ECE1-3	HUMAN|HGNC=13275|UniProtKB=O60344	Endothelin-converting enzyme 2	RCA			PTHR11733:SF127	ENDOTHELIN-CONVERTING ENZYME 2
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04398	p53 pathway feedback loops 2	G04714	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00029	Huntington disease	P00805	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	IC	10074940	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00056	VEGF signaling pathway	P01417	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	3449797	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00059	p53 pathway	P04609	PI3K	CANAL|CGD=CAL0068551|UniProtKB=Q5AAR9	Phosphatidylinositol 3-kinase	ISS	10870104	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05730	Endogenous cannabinoid signaling	P05743	CB1	PANTR|Ensembl=ENSPTRG00000018411|UniProtKB=Q5IS73	Cannabinoid receptor 1	ISS	2165569	PubMed	PTHR22750:SF47	CANNABINOID RECEPTOR 1
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	YEAST|SGD=S000000638|UniProtKB=P23255	Transcription initiation factor TFIID subunit 2	ISS			PTHR15137:SF9	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05913	Enkephalin release	P05977	G-Protein (s)	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00557	PI3K	DANRE|ZFIN=ZDB-GENE-040426-1128|UniProtKB=F1RB17	Uncharacterized protein	ISS			PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P02770	Pyridoxal phosphate salvage pathway	P03121	Pyridoxal kinase	MOUSE|MGI=MGI=1351869|UniProtKB=Q8K183	Pyridoxal kinase	ISS	20344886	gi	PTHR10534:SF2	PYRIDOXAL KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_127490|UniProtKB=C3XYC5	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00005	Angiogenesis	P00226	Delta/Serrate	MOUSE|MGI=MGI=1096877|UniProtKB=O88516	Delta-like protein 3	ISS	12175503	PubMed	PTHR24044:SF308	DELTA-LIKE PROTEIN 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	RAT|RGD=2746|UniProtKB=P31424	Metabotropic glutamate receptor 5	IDA	9407094	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00048	PI3 kinase pathway	P01181	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00029	Huntington disease	P00777	CBP	MOUSE|MGI=MGI=1276116|UniProtKB=B2RWS6	Histone acetyltransferase p300	ISS	8413673	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000002647|UniProtKB=F7DIB7	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	CANLF|Ensembl=ENSCAFG00000017647|UniProtKB=F1PHQ0	Clathrin heavy chain	ISS	9388255	PubMed	PTHR10292:SF7	CLATHRIN HEAVY CHAIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	MACMU|Ensembl=ENSMMUG00000010987|UniProtKB=F7GCX9	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	HUMAN|HGNC=708|UniProtKB=O15511	Actin-related protein 2/3 complex subunit 5	IDA	9230079	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	TAS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00006	Apoptosis signaling pathway	P00321	HSP70	XENTR|Xenbase=XB-GENE-480060|UniProtKB=F6UZ27	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	BACSU|EnsemblGenome=BSU15520|UniProtKB=P25994	Carbamoyl-phosphate synthase pyrimidine-specific large chain	ISS			PTHR11405:SF5	CAD PROTEIN
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00019	Endothelin signaling pathway	P00577	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	IGI	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CANLF|Ensembl=ENSCAFG00000016020|UniProtKB=O18840	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04393	Ras Pathway	P04573	Elk-1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	IDA	3183861	gi	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	CANLF|Ensembl=ENSCAFG00000004956|UniProtKB=E2REH3	Uncharacterized protein	ISS	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04397	p53 pathway by glucose deprivation	P04639	AMPK	CANLF|Ensembl=ENSCAFG00000008750|UniProtKB=F1PBG0	Uncharacterized protein	ISS			PTHR13780:SF38	5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00005	Angiogenesis	P00185	JAK1	RAT|RGD=69056|UniProtKB=G3V9W2	Tyrosine-protein kinase	ISS	11929133	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00021	FGF signaling pathway	P00628	JNK1-3	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01162	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00045	Notch signaling pathway	P01108	Nicastrin	MOUSE|MGI=MGI=1891700|UniProtKB=P57716	Nicastrin	TAS	16096062	PubMed	PTHR21092:SF0	NICASTRIN
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00623	FGF	PANTR|Ensembl=ENSPTRG00000016853|UniProtKB=H2QQU8	Fibroblast growth factor	ISS	20411101	PubMed	PTHR11486:SF21	FIBROBLAST GROWTH FACTOR 10
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00018	EGF receptor signaling pathway	P00560	Raf-1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IGI	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00797	p53	CANLF|Gene=TP53|UniProtKB=Q29537	Cellular tumor antigen p53	TAS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00019	Endothelin signaling pathway	P00591	PLCbeta	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347742|UniProtKB=E9FZ00	Cytoplasmatic actin	ISS	14684598	PubMed	PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	97102671	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05730	Endogenous cannabinoid signaling	P05751	Galpha	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00020	FAS signaling pathway	P00607	Pro-Caspase6	RAT|RGD=70967|UniProtKB=O35397	Caspase-6	ISS	11463840	PubMed	PTHR10454:SF164	CASPASE-6
P00060	Ubiquitin proteasome pathway	P01492	E1	HUMAN|HGNC=30660|UniProtKB=Q9UBE0	SUMO-activating enzyme subunit 1	ISS			PTHR10953:SF162	SUMO-ACTIVATING ENZYME SUBUNIT 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	2372396	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	SCHPO|PomBase=SPAC144.03|UniProtKB=Q02787	Adenylosuccinate synthetase	IEP	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00049	Parkinson disease	G01547	DAT	MACMU|Ensembl=ENSMMUG00000005198|UniProtKB=Q7JHP9	Transporter	IDA	92107910	PubMed	PTHR11616:SF38	SODIUM-DEPENDENT DOPAMINE TRANSPORTER
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MOUSE|MGI=MGI=1338824|UniProtKB=O54828	Regulator of G-protein signaling 9	IDA	8756726	PubMed	PTHR10845:SF170	REGULATOR OF G-PROTEIN SIGNALING 9
P00018	EGF receptor signaling pathway	P00557	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04393	Ras Pathway	P04542	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MOUSE|MGI=MGI=1915021|UniProtKB=Q9CPW4	Actin-related protein 2/3 complex subunit 5	ISS	10322212	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00053	T cell activation	P01300	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IC	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	CHLTR|EnsemblGenome=CT_827|UniProtKB=O84834	Ribonucleoside-diphosphate reductase subunit alpha	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00057	Wnt signaling pathway	P01443	Phospholipase C	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00059	p53 pathway	G04705	p48	RAT|RGD=1310164|UniProtKB=D3ZR08	Protein Ddb2	ISS			PTHR15169:SF2	DNA DAMAGE-BINDING PROTEIN 2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	PANTR|Ensembl=ENSPTRG00000004215|UniProtKB=H2Q4M7	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF143	MATRILYSIN
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	IDA	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05913	Enkephalin release	P05972	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	HUMAN|HGNC=6854|UniProtKB=Q9Y2U5	Mitogen-activated protein kinase kinase kinase 2	NAS	11730323	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00010	B cell activation	P00372	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	4504111	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P05731	GABA-B receptor II signaling	P05752	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01286	TGFbeta	DANRE|ZFIN=ZDB-GENE-010226-1|UniProtKB=Q98TU0	Glial cell line-derived neurotrophic factor	TAS	10779363	PubMed	PTHR12173:SF1	GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR
P00034	Integrin signalling pathway	P00920	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IPI	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00012	Cadherin signaling pathway	P00471	Cadherin	CANLF|Ensembl=ENSCAFG00000017514|UniProtKB=E2REK7	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF40	PROTOCADHERIN-19
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	MOUSE|MGI=MGI=109576|UniProtKB=Q6PDZ2	TATA box-binding protein-associated factor RNA polymerase I subunit C	ISS	604905	OMIM	PTHR15319:SF1	TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT C
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000020588|UniProtKB=F7C0E0	Uncharacterized protein	ISS	10644715	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	MOUSE|MGI=MGI=87994|UniProtKB=P05064	Fructose-bisphosphate aldolase A	ISS	74094688	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00059	p53 pathway	P04633	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	RAT|RGD=69319|UniProtKB=P54313	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00053	T cell activation	P01304	Csk	PANTR|Ensembl=ENSPTRG00000007282|UniProtKB=H2Q9T1	Tyrosine-protein kinase	ISS	12665526	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00004	Alzheimer disease-presenilin pathway	P00114	actin	XENTR|Xenbase=XB-GENE-6469705|UniProtKB=Q6P8G3	Actin, alpha sarcomeric/skeletal	ISS	11889126	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P02771	Pyrimidine Metabolism	P03131	5'-Nucleotidase	HUMAN|HGNC=8021|UniProtKB=P21589	5'-nucleotidase	RCA	8224905	PubMed	PTHR11575:SF25	5'-NUCLEOTIDASE
P00005	Angiogenesis	P00199	JNKK1	HUMAN|HGNC=6844|UniProtKB=P45985	Dual specificity mitogen-activated protein kinase kinase 4	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IDA	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000004742|UniProtKB=H2Q5K1	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P04393	Ras Pathway	P04557	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	IDA	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00807	Actin	XENTR|Xenbase=XB-GENE-491938|UniProtKB=Q6DIV8	Actin, alpha 1, skeletal muscle	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00025	Hedgehog signaling pathway	P00692	GSK3	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	MOUSE|MGI=MGI=1202879|UniProtKB=Q924A0	Transcription factor 7-like 2	TAS	12356903	PubMed	PTHR10373:SF32	TRANSCRIPTION FACTOR 7-LIKE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	MYCTU|EnsemblGenome=Rv2334|UniProtKB=P9WP55	O-acetylserine sulfhydrylase	ISS			PTHR10314:SF159	CYSTEINE SYNTHASE A
P00010	B cell activation	P00368	vav	HUMAN|HGNC=12659|UniProtKB=Q9UKW4	Guanine nucleotide exchange factor VAV3	IGI	14623913	PubMed	PTHR22826:SF97	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=11433|UniProtKB=Q16623	Syntaxin-1A	ISS	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00019	Endothelin signaling pathway	P00566	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	HUMAN|HGNC=8591|UniProtKB=Q13177	Serine/threonine-protein kinase PAK 2	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	PANTR|Ensembl=ENSPTRG00000005122|UniProtKB=H2Q6A6	Uncharacterized protein	ISS	11907044	PubMed	PTHR44025:SF2	PROLOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00049	Parkinson disease	P01227	20S proteasome	ORYSJ|EnsemblGenome=OS05G0187000|UniProtKB=Q9LST8	Proteasome subunit beta type	TAS	12859888	PubMed	PTHR11599:SF44	AT05866P-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P06664	Gonadotropin-releasing hormone receptor pathway	P06807	gnai	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	TAS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00048	PI3 kinase pathway	P01181	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	SCHPO|PomBase=SPAC110.03|UniProtKB=Q01112	Cell division control protein 42 homolog	ISS	12932731	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	IDA	1319556	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00018	EGF receptor signaling pathway	P00547	PP2A	ORNAN|Ensembl=ENSOANG00000009097|UniProtKB=F7G755	Uncharacterized protein	ISS	8703017	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00010	B cell activation	P00383	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05730	Endogenous cannabinoid signaling	P05746	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DANRE|ZFIN=ZDB-GENE-030131-9966|UniProtKB=Q6TH03	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	ANOGA|EnsemblGenome=AGAP005913|UniProtKB=Q7Q6D2	AGAP005913-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DROME|FlyBase=FBgn0001122|UniProtKB=P16378	G protein alpha o subunit	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04384	Gamma-aminobutyric acid synthesis	P04482	Glutamate decarboxylase	PANTR|Ensembl=ENSPTRG00000005004|UniProtKB=H2R1K8	Uncharacterized protein	ISS			PTHR11999:SF114	CYSTEINE SULFINIC ACID DECARBOXYLASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00887	IRS 1-4	PANTR|Ensembl=ENSPTRG00000012989|UniProtKB=H2QJJ4	Insulin receptor substrate 1	ISS	5031805	gi	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00034	Integrin signalling pathway	P00906	Rap1	PANTR|Ensembl=ENSPTRG00000005983|UniProtKB=H2Q7Q7	RAP2A, member of RAS oncogene family	ISS	8576107	PubMed	PTHR24070:SF221	RAS-RELATED PROTEIN RAP-2A
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CANLF|Ensembl=ENSCAFG00000015708|UniProtKB=F2Z4N0	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	PANTR|Ensembl=ENSPTRG00000008601|UniProtKB=H2QBY1	Arrestin, beta 2	ISS	4757780	gi	PTHR11792:SF20	BETA-ARRESTIN-2
P02738	De novo purine biosynthesis	P02907	dADP kinase	CANLF|Ensembl=ENSCAFG00000012923|UniProtKB=F1PEK4	Uncharacterized protein	ISS			PTHR44107:SF3	DOWN SYNDROME CELL ADHESION MOLECULE-LIKE PROTEIN 1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	THEMA|EnsemblGenome=TM_0557|UniProtKB=Q9WZ27	Carbamoyl-phosphate synthase large chain	ISS			PTHR11405:SF5	CAD PROTEIN
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	IC	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	CAEEL|WormBase=WBGene00000897|UniProtKB=P20792	Cell surface receptor daf-1	ISS	9395284	PubMed	PTHR23255:SF95	CELL SURFACE RECEPTOR DAF-1
P00012	Cadherin signaling pathway	P00462	Casein kinase II	ANOGA|EnsemblGenome=AGAP005569|UniProtKB=Q7Q707	AGAP005569-PA	ISS	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00474	Wnt	XENTR|Xenbase=XB-GENE-493706|UniProtKB=Q28IC7	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00049	Parkinson disease	P01235	Fyn kinase	MONDO|Ensembl=ENSMODG00000017905|UniProtKB=F7FG65	Tyrosine-protein kinase	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00034	Integrin signalling pathway	P00950	Paxillin	PANTR|Ensembl=ENSPTRG00000005527|UniProtKB=H2Q704	Paxillin	ISS	9182576	PubMed	PTHR24216:SF11	PAXILLIN
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	IDA	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04393	Ras Pathway	P04567	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	IDA	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	RAT|RGD=3187|UniProtKB=Q07008	Neurogenic locus notch homolog protein 1	IDA	1764995	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MONDO|Ensembl=ENSMODG00000005623|UniProtKB=F7CFG8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00034	Integrin signalling pathway	P00948	Rho	DANRE|ZFIN=ZDB-GENE-040426-2150|UniProtKB=Q6NUX8	Rho-related GTP-binding protein RhoA-A	ISS	11973360	PubMed	PTHR24072:SF260	RHO-RELATED GTP-BINDING PROTEIN RHOA-A-RELATED
P00046	Oxidative stress response	P01132	c-jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00034	Integrin signalling pathway	P00949	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	8264585	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00588	ET1-4	RAT|RGD=2532|UniProtKB=P22388	Endothelin-1	ISS	15117818	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P00018	EGF receptor signaling pathway	P00539	14-3-3	CHLRE|EnsemblGenome=CHLREDRAFT_185967|UniProtKB=A8JGV6	14-3-3 protein	IGI	95359208	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00049	Parkinson disease	P01242	Casein kinase I	XENTR|Xenbase=XB-GENE-5733929|UniProtKB=Q6P647	Casein kinase I isoform delta	ISS	10617630	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00018	EGF receptor signaling pathway	P00543	ERK1-2	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MACMU|Ensembl=ENSMMUG00000007154|UniProtKB=F7DHF4	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF149	REGULATOR OF G-PROTEIN SIGNALING 12
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00021	FGF signaling pathway	P00624	14-3-3	TAKRU|Ensembl=ENSTRUG00000004697|UniProtKB=H2SFG7	Uncharacterized protein	ISS	8381897	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00056	VEGF signaling pathway	P01425	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00049	Parkinson disease	P01219	SAPK	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	NAS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	RAT|RGD=628595|UniProtKB=Q4QRB4	Tubulin beta-3 chain	ISS	12932731	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	CAEEL|WormBase=WBGene00004958|UniProtKB=Q01608	Presenilin spe-4	TAS	8755489	PubMed	PTHR10202:SF17	PRESENILIN SPE-4
P00018	EGF receptor signaling pathway	P00557	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IGI	129387	gi	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00034	Integrin signalling pathway	P00926	GRAF	MOUSE|MGI=MGI=1925764|UniProtKB=Q6Y5D8	Rho GTPase-activating protein 10	ISS	8649427	PubMed	PTHR12552:SF5	RHO GTPASE-ACTIVATING PROTEIN 10
P00047	PDGF signaling pathway	P01167	Ets	MACMU|Ensembl=ENSMMUG00000001929|UniProtKB=F6TYX0	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF13	ETS-RELATED TRANSCRIPTION FACTOR ELF-3
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	ECOLI|EcoGene=EG10032|UniProtKB=P69441	Adenylate kinase	ISS			PTHR23359:SF22	GTP:AMP PHOSPHOTRANSFERASE, MITOCHONDRIAL
P00057	Wnt signaling pathway	P01451	Galpha	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P06587	Nicotine pharmacodynamics pathway	P06605	KCNK3/9	HUMAN|HGNC=6283|UniProtKB=Q9NPC2	Potassium channel subfamily K member 9	RCA	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P06664	Gonadotropin-releasing hormone receptor pathway	P06794	MAP2K1/2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	RCA	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	MACMU|Ensembl=ENSMMUG00000023317|UniProtKB=F6Y514	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00005	Angiogenesis	P00231	HSP27	RAT|RGD=70914|UniProtKB=O35878	Heat shock protein beta-2	ISS			PTHR11527:SF163	HEAT SHOCK PROTEIN BETA-2
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00644	p38	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	IGI	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00049	Parkinson disease	P01242	Casein kinase I	CAEEL|WormBase=WBGene00011283|UniProtKB=Q22033	Uncharacterized protein	IDA	10617630	PubMed	PTHR11909:SF19	ASATOR, ISOFORM D
P00053	T cell activation	P01318	PKC-theta	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IGI	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01052	AC	HUMAN|HGNC=21285|UniProtKB=Q96PN6	Adenylate cyclase type 10	ISS	11744988	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	IC	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00048	PI3 kinase pathway	P01199	Galpha	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04393	Ras Pathway	P04579	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IDA	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05918	p38 MAPK pathway	P06017	MNK2	BOVIN|Ensembl=ENSBTAG00000018049|UniProtKB=E1BCH7	Uncharacterized protein	ISS	9155017	PubMed	PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	MOUSE|MGI=MGI=97511|UniProtKB=P63239	Neuroendocrine convertase 1	IDA			PTHR42884:SF14	NEUROENDOCRINE CONVERTASE 1
P02756	N-acetylglucosamine metabolism	P03041	Glucosamine-6-phosphate deaminase	CANLF|Ensembl=ENSCAFG00000006243|UniProtKB=E2QX53	Glucosamine-6-phosphate isomerase	ISS			PTHR11280:SF8	GLUCOSAMINE-6-PHOSPHATE ISOMERASE 1
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	MACMU|Ensembl=ENSMMUG00000019112|UniProtKB=F6T8S6	N-methyl D-aspartate receptor subtype 2B	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00047	PDGF signaling pathway	P01159	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DANRE|ZFIN=ZDB-GENE-030131-172|UniProtKB=Q6IQR3	Actin, alpha, cardiac muscle 1a	IC	11889126	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00010	B cell activation	P00383	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8440264	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00055	Transcription regulation by bZIP transcription factor	P01396	TFIIFbeta	CANLF|Ensembl=ENSCAFG00000012900|UniProtKB=E2RGQ0	Uncharacterized protein	ISS	92020241	PubMed	PTHR10445:SF0	GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2
P00021	FGF signaling pathway	P00639	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	10982827	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	CAEBR|Gene=CBG17377|UniProtKB=A8XQX9	Adenylate kinase isoenzyme 1	ISS			PTHR23359:SF70	ADENYLATE KINASE 1, ISOFORM B
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IDA	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00591	PLCbeta	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	CHICK|Ensembl=ENSGALG00000015358|UniProtKB=F1NM49	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF575	MYOSIN-15
P00018	EGF receptor signaling pathway	P00539	14-3-3	ANOGA|EnsemblGenome=AGAP001151|UniProtKB=Q7PX08	AGAP001151-PA	ISS	97302963	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	PANTR|Ensembl=ENSPTRG00000021201|UniProtKB=H2QXL7	Fructose-bisphosphate aldolase	ISS	8086469	PubMed	PTHR11627:SF2	FRUCTOSE-BISPHOSPHATE ALDOLASE B
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DICDI|dictyBase=DDB_G0277143|UniProtKB=P36408	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P02751	Lysine biosynthesis	P03008	Dihydrodipicolinate synthase	SULSO|EnsemblGenome=SSO3035|UniProtKB=Q97UI2	Dihydrodipicolinate synthase (DapA-2)	ISS			PTHR12128:SF15	4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	HUMAN|HGNC=4587|UniProtKB=Q14957	Glutamate receptor ionotropic, NMDA 2C	IC	11554549	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	IDA	15621031	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02775	Salvage pyrimidine ribonucleotides	P03151	Uracil phosphoribosyl  transferase	MACMU|Ensembl=ENSMMUG00000021204|UniProtKB=F7GXS8	Uncharacterized protein	ISS			PTHR10285:SF90	URACIL PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IDA	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00010	B cell activation	P00386	Calcineurin	XENTR|Xenbase=XB-GENE-952299|UniProtKB=B0BLZ8	Serine/threonine-protein phosphatase	ISS	7532676	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00057	Wnt signaling pathway	P01432	Beta-Catenin	BOVIN|Ensembl=ENSBTAG00000016420|UniProtKB=Q0VCX4	Catenin beta-1	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P00029	Huntington disease	P00812	Caspase 3	MACMU|Ensembl=ENSMMUG00000012053|UniProtKB=F7HFY2	Uncharacterized protein	ISS	7983002	PubMed	PTHR10454:SF198	CASPASE-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00018	EGF receptor signaling pathway	P00552	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00019	Endothelin signaling pathway	P00577	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00973	PKB	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00819	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00935	ILK	MOUSE|MGI=MGI=1195267|UniProtKB=O55222	Integrin-linked protein kinase	ISS			PTHR44344:SF1	INTEGRIN-LINKED PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CAEEL|WormBase=WBGene00000066|UniProtKB=P10986	Actin-4	IDA	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00519	ROCK	RAT|RGD=620424|UniProtKB=Q63644	Rho-associated protein kinase 1	ISS	10779382	PubMed	PTHR22988:SF33	RHO-ASSOCIATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04393	Ras Pathway	P04546	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	IDA	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	PYRAE|EnsemblGenome=PAE0947|UniProtKB=Q8ZY48	Carbamoyl-phosphate synthase large chain	ISS			PTHR11405:SF5	CAD PROTEIN
P02761	Pantothenate biosynthesis	P03069	2-Dehydropantoate reductase	RHOBA|EnsemblGenome=RB12638|UniProtKB=Q7UIB7	Probable 2-dehydropantoate 2-reductase	ISS			PTHR43765:SF1	2-DEHYDROPANTOATE 2-REDUCTASE
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00009	Axon guidance mediated by netrin	P00359	NFAT	PANTR|Ensembl=ENSPTRG00000006218|UniProtKB=H2Q834	Uncharacterized protein	ISS	12787506	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00053	T cell activation	P01319	PAK	PANTR|Ensembl=ENSPTRG00000022187|UniProtKB=Q7YQL4	Serine/threonine-protein kinase PAK 3	ISS	7559398	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MACMU|Ensembl=ENSMMUG00000014762|UniProtKB=F7G0R4	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF344	MYOSIN-7
P00021	FGF signaling pathway	P00631	Grb2	MOUSE|MGI=MGI=1918770|UniProtKB=Q9CX99	GRB2-related adapter protein	ISS	9741627	PubMed	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00018	EGF receptor signaling pathway	P00540	MKK3,6	ANOGA|EnsemblGenome=AGAP000310|UniProtKB=Q7PRZ7	AGAP000310-PA	ISS			PTHR24361:SF645	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P00053	T cell activation	P01306	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00718	Phosphorylase a	CANLF|Ensembl=ENSCAFG00000014595|UniProtKB=F1PB77	Alpha-1,4 glucan phosphorylase	ISS	4318782	PubMed	PTHR11468:SF12	GLYCOGEN PHOSPHORYLASE, LIVER FORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	IC	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	MOUSE|MGI=MGI=1916026|UniProtKB=Q99JX1	Transcription initiation factor TFIID subunit 11	ISS			PTHR13218:SF8	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	CHICK|Gene=GLUL|UniProtKB=P16580	Glutamine synthetase	ISS			PTHR20852:SF45	GLUTAMINE SYNTHETASE
P00047	PDGF signaling pathway	P01163	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	11840290	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00015	Circadian clock system	G01497	cry	PANTR|Ensembl=ENSPTRG00000005396|UniProtKB=H2Q6S7	Cryptochrome 1 (Photolyase-like)	ISS	10428031	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00029	Huntington disease	P00807	Actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	IDA	11889126	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P06211	BMP/activin signaling pathway-drosophila	P06251	BMP/activin orthologous ligand	DROME|FlyBase=FBgn0024234|UniProtKB=P27091	Protein 60A	RCA	9759503	PubMed	PTHR11848:SF54	PROTEIN 60A-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	IDA	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04393	Ras Pathway	P04541	p90RSK	XENTR|Xenbase=XB-GENE-479496|UniProtKB=F6S876	Ribosomal protein S6 kinase	ISS	3368449	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00021	FGF signaling pathway	P00624	14-3-3	CANLF|Ensembl=ENSCAFG00000000580|UniProtKB=F1PBL1	Uncharacterized protein	ISS	92362864	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00047	PDGF signaling pathway	P01152	RasGAP	HUMAN|HGNC=9871|UniProtKB=P20936	Ras GTPase-activating protein 1	ISS	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00021	FGF signaling pathway	P00644	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00049	Parkinson disease	P01227	20S proteasome	ORNAN|Ensembl=ENSOANG00000004175|UniProtKB=F6UT72	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF14	PROTEASOME SUBUNIT ALPHA TYPE-5
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	RAT|RGD=2674|UniProtKB=Q9Z0J6	Growth/differentiation factor 15	TAS	10779363	PubMed	PTHR11848:SF78	GROWTH/DIFFERENTIATION FACTOR 15
P06959	CCKR signaling map	G06976	REG1A	HUMAN|HGNC=9951|UniProtKB=P05451	Lithostathine-1-alpha	RCA	15109306	PubMed	PTHR43993:SF7	LITHOSTATHINE-1-ALPHA
P04393	Ras Pathway	P04569	Cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00048	PI3 kinase pathway	P01197	Caspase-9	MACMU|Ensembl=ENSMMUG00000018163|UniProtKB=F7FNC1	Caspase	ISS	8663294	PubMed	PTHR10454:SF157	CASPASE-9
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=2136747|UniProtKB=Q91Y07	MCG141300	IDA	8120095	PubMed	PTHR24028:SF95	MCG141300
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P06216	SCW signaling pathway	P06330	TSG	DROME|FlyBase=FBgn0003865|UniProtKB=P54356	Protein twisted gastrulation	IDA	11260716	PubMed	PTHR12312:SF16	TWISTED GASTRULATION PROTEIN HOMOLOG 1-A-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MOUSE|MGI=MGI=87895|UniProtKB=P04760	Acetylcholine receptor subunit gamma	IC	95224005	PubMed	PTHR18945:SF60	ACETYLCHOLINE RECEPTOR SUBUNIT GAMMA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	ARATH|TAIR=AT3G10160|UniProtKB=F4J2K2	Folylpolyglutamate synthase	ISS			PTHR11136:SF7	FOLYLPOLYGLUTAMATE SYNTHASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	HUMAN|HGNC=8591|UniProtKB=Q13177	Serine/threonine-protein kinase PAK 2	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00020	FAS signaling pathway	P00615	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	RAT|RGD=70919|UniProtKB=P08081	Clathrin light chain A	ISS	9388255	PubMed	PTHR10639:SF1	CLATHRIN LIGHT CHAIN A
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00010	B cell activation	P00376	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BOVIN|Ensembl=ENSBTAG00000001668|UniProtKB=F1N6L8	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00006	Apoptosis signaling pathway	P00274	JNK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00048	PI3 kinase pathway	P01192	p110	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00562	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00052	TGF-beta signaling pathway	P01279	Smurfs	PANTR|Ensembl=ENSPTRG00000019444|UniProtKB=H2R545	Uncharacterized protein	ISS	11252892	PubMed	PTHR11254:SF293	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P00005	Angiogenesis	P00190	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	227170	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	PANTR|Ensembl=ENSPTRG00000020930|UniProtKB=H2QX95	Uncharacterized protein	ISS	11889126	PubMed	PTHR10639:SF1	CLATHRIN LIGHT CHAIN A
P06664	Gonadotropin-releasing hormone receptor pathway	P06828	RFRP-1/-3	MOUSE|MGI=MGI=1926488|UniProtKB=Q9ESQ8	Pro-FMRFamide-related neuropeptide VF	RCA			PTHR14403:SF6	PRO-FMRFAMIDE-RELATED NEUROPEPTIDE VF
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	HUMAN|HGNC=16767|UniProtKB=Q8TCU5	Glutamate receptor ionotropic, NMDA 3A	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	G01544	GADD45	MOUSE|MGI=MGI=107799|UniProtKB=P48316	Growth arrest and DNA damage-inducible protein GADD45 alpha	ISS	10097101	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	ARATH|TAIR=AT1G79000|UniProtKB=Q9C5X9	Histone acetyltransferase HAC1	TAS	10769018	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00021	FGF signaling pathway	P00636	FGFR1-4	ORNAN|Ensembl=ENSOANG00000003252|UniProtKB=F6SM70	Fibroblast growth factor receptor	ISS	12799194	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P00036	Interleukin signaling pathway	P00964	p90RSK	BOVIN|Ensembl=ENSBTAG00000017639|UniProtKB=F1MZW8	Ribosomal protein S6 kinase	ISS	10558991	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00048	PI3 kinase pathway	P01192	p110	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00020	FAS signaling pathway	P00608	Pro-Caspase3	HUMAN|HGNC=1504|UniProtKB=P42574	Caspase-3	IGI	9323209	PubMed	PTHR10454:SF198	CASPASE-3
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00046	Oxidative stress response	P01129	JNK1/2	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	TAS	10514528	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00052	TGF-beta signaling pathway	P01275	P38	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	IC	11319238	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	12707323	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P06664	Gonadotropin-releasing hormone receptor pathway	P06742	NF-Y	MOUSE|MGI=MGI=97317|UniProtKB=P63139	Nuclear transcription factor Y subunit beta	RCA			PTHR11064:SF80	NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA
P00012	Cadherin signaling pathway	P00471	Cadherin	CHICK|Gene=CDH20|UniProtKB=Q8QGH3	Cadherin-20	IDA	8120095	PubMed	PTHR24027:SF84	CADHERIN-20
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	RCA	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10557357	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT1G10210|UniProtKB=Q39021	Mitogen-activated protein kinase 1	IDA	176948	OMIM	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00029	Huntington disease	P00785	Cytochrome c	ARATH|TAIR=AT5G40810|UniProtKB=Q9FKS5	Cytochrome c1 2, heme protein, mitochondrial	IDA	15163634	PubMed	PTHR10266:SF6	CYTOCHROME C1 1, HEME PROTEIN, MITOCHONDRIAL-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	TAKRU|Ensembl=ENSTRUG00000016241|UniProtKB=H2UX35	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF305	PROTEIN KINASE C
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MOUSE|MGI=MGI=108570|UniProtKB=Q61090	Frizzled-7	TAS	8717036	PubMed	PTHR11309:SF31	FRIZZLED-7
P00057	Wnt signaling pathway	P01428	Frizzled	RAT|RGD=71017|UniProtKB=Q9QZH0	Frizzled-4	IDA	11212302	PubMed	PTHR11309:SF23	FRIZZLED-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	CHICK|Gene=COL14A1|UniProtKB=P32018	Collagen alpha-1(XIV) chain	IC	10778855	PubMed	PTHR44557:SF1	COLLAGEN ALPHA-1 XIV  CHAIN
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01446	Calcineurin	MOUSE|MGI=MGI=107164|UniProtKB=P63328	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	ISS	12091710	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	BOVIN|Ensembl=ENSBTAG00000005714|UniProtKB=Q3ZC07	Actin, alpha cardiac muscle 1	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	ISS	91072385	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00046	Oxidative stress response	P01129	JNK1/2	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	TAS	10851062	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	XENTR|Xenbase=XB-GENE-957124|UniProtKB=F7BDN8	Uncharacterized protein	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00021	FGF signaling pathway	P00636	FGFR1-4	CANLF|Ensembl=ENSCAFG00000005970|UniProtKB=E2R186	Fibroblast growth factor receptor	ISS	12799194	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IDA	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05941	GRK3	DANRE|ZFIN=ZDB-GENE-030616-382|UniProtKB=B5LZ08	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF18	PROTEIN-SERINE/THREONINE KINASE
P00047	PDGF signaling pathway	P01168	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	10799299	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00045	Notch signaling pathway	P01101	Su(H)	RAT|RGD=1304786|UniProtKB=D4AEG0	Protein Rbpjl	ISS	12681948	PubMed	PTHR10665:SF2	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS-LIKE PROTEIN
P00036	Interleukin signaling pathway	P00976	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00005	Angiogenesis	P00238	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6879|UniProtKB=Q16659	Mitogen-activated protein kinase 6	IDA	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CAEBR|Gene=CBG23090|UniProtKB=A8Y4R0	Protein CBG23090	ISS	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00053	T cell activation	P01331	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02738	De novo purine biosynthesis	P02907	dADP kinase	YEAST|SGD=S000001550|UniProtKB=P36010	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00048	PI3 kinase pathway	P01188	Gbetagamma	ANOGA|EnsemblGenome=AGAP005913|UniProtKB=Q7Q6D2	AGAP005913-PA	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	ORNAN|Ensembl=ENSOANG00000007722|UniProtKB=F6QTD4	Uncharacterized protein	ISS			PTHR13140:SF438	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00034	Integrin signalling pathway	P00931	Integrin beta	CANLF|Ensembl=ENSCAFG00000005918|UniProtKB=E2QY83	Uncharacterized protein	ISS	3487386	PubMed	PTHR10082:SF3	INTEGRIN BETA-LIKE PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00118	E-cadherin	HUMAN|HGNC=1762|UniProtKB=P22223	Cadherin-3	IDA	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00009	Axon guidance mediated by netrin	P00366	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00006	Apoptosis signaling pathway	P00260	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P05913	Enkephalin release	P05974	G-Protein (i)	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	IC	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MOUSE|MGI=MGI=87902|UniProtKB=P68134	Actin, alpha skeletal muscle	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CANLF|Ensembl=ENSCAFG00000010787|UniProtKB=E2R3W6	Uncharacterized protein	ISS	1319557	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00235	c-Fos	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	IDA	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P05916	Opioid prodynorphin pathway	P06001	AC	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00005	Angiogenesis	P00221	JNK1	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01150	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	14744428	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P05918	p38 MAPK pathway	P06031	p38alpha	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01452	NFAT	HUMAN|HGNC=7777|UniProtKB=Q12968	Nuclear factor of activated T-cells, cytoplasmic 3	IDA	12787506	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MACMU|Ensembl=ENSMMUG00000010266|UniProtKB=F6PV18	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00045	Notch signaling pathway	P01112	CoR	PANTR|Ensembl=ENSPTRG00000012652|UniProtKB=H2QJ01	Uncharacterized protein	ISS	11112321	PubMed	PTHR13151:SF2	COREPRESSOR INTERACTING WITH RBPJ 1
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000007909|UniProtKB=F1MPE9	Uncharacterized protein	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	HUMAN|HGNC=4597|UniProtKB=P41594	Metabotropic glutamate receptor 5	ISS	92317054	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00778	NMDA receptor	MOUSE|MGI=MGI=95821|UniProtKB=Q01097	Glutamate receptor ionotropic, NMDA 2B	IDA	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Ensembl=ENSGALG00000009844|UniProtKB=P68034	Actin, alpha cardiac muscle 1	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P02747	Histidine biosynthesis	P02987	ATP phosphoribosyl transferase	GLOVI|EnsemblGenome=BAC91324|UniProtKB=Q7NFZ1	ATP phosphoribosyltransferase	ISS			PTHR21403:SF4	ATP PHOSPHORIBOSYLTRANSFERASE
P00005	Angiogenesis	P00225	MEK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS			PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04398	p53 pathway feedback loops 2	P04663	Mdm2	RAT|RGD=1305332|UniProtKB=A0A0G2JVC1	Protein Mdm2	ISS	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-478663|UniProtKB=F7EG64	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00019	Endothelin signaling pathway	P00573	signal peptidase	DROME|FlyBase=FBgn0262801|UniProtKB=O97066	Signal peptidase complex catalytic subunit SEC11	ISS	2674115	PubMed	PTHR10806:SF6	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11
P00005	Angiogenesis	P00226	Delta/Serrate	DANRE|ZFIN=ZDB-GENE-000125-4|UniProtKB=Q9IAT6	Delta-like protein C	ISS			PTHR24044:SF308	DELTA-LIKE PROTEIN 3
P00018	EGF receptor signaling pathway	P00548	RKIP	HUMAN|HGNC=8630|UniProtKB=P30086	Phosphatidylethanolamine-binding protein 1	ISS	92031654	PubMed	PTHR11362:SF28	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05915	Opioid proenkephalin pathway	P05994	G-protein	XENTR|Xenbase=XB-GENE-969601|UniProtKB=Q28H40	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=12783|UniProtKB=P56705	Protein Wnt-4	IDA	11266476	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P05730	Endogenous cannabinoid signaling	P05746	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00006	Apoptosis signaling pathway	P00269	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00009	Axon guidance mediated by netrin	P00364	cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00023	General transcription regulation	P00658	TBP-associated factors	CANLF|Ensembl=ENSCAFG00000024324|UniProtKB=E2QVZ3	Uncharacterized protein	ISS			PTHR12264:SF21	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00566	ERK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	NAS	6466184	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P02748	Isoleucine biosynthesis	P02997	Acetolactate synthase	HUMAN|HGNC=6041|UniProtKB=A1L0T0	Acetolactate synthase-like protein	ISS			PTHR18968:SF155	ACETOLACTATE SYNTHASE-LIKE PROTEIN
P00019	Endothelin signaling pathway	P00573	signal peptidase	CHICK|Ensembl=ENSGALG00000002839|UniProtKB=F1NAZ9	Signal peptidase complex catalytic subunit SEC11	ISS	2674115	PubMed	PTHR10806:SF12	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11C
P00005	Angiogenesis	P00200	Dsh	CANLF|Ensembl=ENSCAFG00000012180|UniProtKB=F1PIB1	Uncharacterized protein	ISS	11212302	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00006	Apoptosis signaling pathway	P00269	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00641	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IGI	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	HUMAN|HGNC=1952|UniProtKB=P20309	Muscarinic acetylcholine receptor M3	TAS	10069496	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00049	Parkinson disease	P01232	CASK	MACMU|Ensembl=ENSMMUG00000022578|UniProtKB=F7BKQ5	Uncharacterized protein	ISS	11430913	PubMed	PTHR23122:SF40	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P02761	Pantothenate biosynthesis	P03069	2-Dehydropantoate reductase	AQUAE|EnsemblGenome=aq_1727|UniProtKB=O67619	Putative 2-dehydropantoate 2-reductase	ISS			PTHR43765:SF1	2-DEHYDROPANTOATE 2-REDUCTASE
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	ANOGA|EnsemblGenome=AGAP001478|UniProtKB=Q7PXM3	AGAP001478-PA	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_125401|UniProtKB=C3ZTX6	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS	88311074	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00001	Adrenaline and noradrenaline biosynthesis	P00069	COMT	HUMAN|HGNC=2228|UniProtKB=P21964	Catechol O-methyltransferase	ISS	12842307	PubMed	PTHR43836:SF3	CATECHOL O-METHYLTRANSFERASE
P00010	B cell activation	P00391	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	HUMAN|HGNC=1951|UniProtKB=P08172	Muscarinic acetylcholine receptor M2	ISS	11166329	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00790	beta-Tubulin	PHYPA|Gene=PHYPADRAFT_117822|UniProtKB=A9RQS1	Predicted protein	ISS	12932731	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	MOUSE|MGI=MGI=99917|UniProtKB=P56564	Excitatory amino acid transporter 1	ISS	94365697	PubMed	PTHR11958:SF24	EXCITATORY AMINO ACID TRANSPORTER 1
P00029	Huntington disease	P00790	beta-Tubulin	CAEEL|WormBase=WBGene00000248|UniProtKB=Q18817	Uncharacterized protein	TAS	9454836	PubMed	PTHR11588:SF120	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04398	p53 pathway feedback loops 2	P04665	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00819	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P01485	p53	HUMAN|HGNC=11998|UniProtKB=P04637	Cellular tumor antigen p53	TAS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00046	Oxidative stress response	P01124	Myc	CHICK|Ensembl=ENSGALG00000016308|UniProtKB=P01109	Myc proto-oncogene protein	TAS	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00001	Adrenaline and noradrenaline biosynthesis	P00066	DOPA decarb.	CAEEL|WormBase=WBGene00001839|UniProtKB=P34751	Probable aromatic-L-amino-acid decarboxylase	ISS			PTHR11999:SF59	AROMATIC-L-AMINO-ACID DECARBOXYLASE-RELATED
P00019	Endothelin signaling pathway	P00590	IP3 R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00005	Angiogenesis	P00206	Wnt	RAT|RGD=69346|UniProtKB=G3V7U3	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	RAT|RGD=2738|UniProtKB=Q00960	Glutamate receptor ionotropic, NMDA 2B	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00046	Oxidative stress response	P01125	Stat1	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	SCHPO|PomBase=SPAC6G9.11|UniProtKB=Q92356	Synaptobrevin homolog 1	ISS			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DANRE|ZFIN=ZDB-GENE-030131-6503|UniProtKB=Q7ZUC5	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF297	PROTEIN KINASE C DELTA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	MOUSE|MGI=MGI=894297|UniProtKB=O08585	Clathrin light chain A	ISS	11889126	PubMed	PTHR10639:SF1	CLATHRIN LIGHT CHAIN A
P00057	Wnt signaling pathway	P01465	Ggamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P02723	Adenine and hypoxanthine salvage pathway	P02811	Adenosine deaminase	ANOGA|EnsemblGenome=AGAP005158|UniProtKB=Q7Q9M2	AGAP005158-PA	ISS			PTHR11409:SF42	ADENOSINE DEAMINASE-LIKE PROTEIN
P06211	BMP/activin signaling pathway-drosophila	P06249	TLD	DROME|FlyBase=FBgn0003719|UniProtKB=P25723	Dorsal-ventral patterning protein tolloid	IDA	9759503	PubMed	PTHR43978:SF2	DORSAL-VENTRAL PATTERNING PROTEIN TOLLOID-RELATED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=1261834|UniProtKB=O70283	Protein Wnt-2b	TAS	8717036	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P04395	Vasopressin synthesis	P04597	Signal Peptide	RAT|RGD=3238|UniProtKB=P01179	Oxytocin-neurophysin 1	ISS	3768139	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00029	Huntington disease	P00780	Microtubule	ASHGO|EnsemblGenome=AGOS_ACR225C|UniProtKB=Q75BP6	ACR225Cp	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00024	Glycolysis	P00672	Phosphofructokinase-1	MOUSE|MGI=MGI=97548|UniProtKB=P47857	ATP-dependent 6-phosphofructokinase, muscle type	RCA			PTHR13697:SF13	ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE, MUSCLE TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00219	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00054	Toll receptor signaling pathway	P01375	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	P01455	Smad4	MONDO|Ensembl=ENSMODG00000010995|UniProtKB=F7A1M2	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	11256888	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	TAS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00589	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00269	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	LEPIN|EnsemblGenome=LA_1313|UniProtKB=Q8F6J3	Glutamine synthetase	ISS			PTHR43407:SF1	LENGSIN
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	HUMAN|HGNC=6015|UniProtKB=P24394	Interleukin-4 receptor subunit alpha	IDA	2278997	PubMed	PTHR23037:SF32	INTERLEUKIN-4 RECEPTOR SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05730	Endogenous cannabinoid signaling	P05746	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PHYPA|Gene=PHYPADRAFT_172686|UniProtKB=A9TYG6	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	IDA	20451058	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01443	Phospholipase C	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00036	Interleukin signaling pathway	P00964	p90RSK	MONDO|Ensembl=ENSMODG00000006241|UniProtKB=F7FRY0	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00029	Huntington disease	P00788	Calpain	CANLF|Ensembl=ENSCAFG00000018175|UniProtKB=F1PB63	Uncharacterized protein	ISS	11675509	PubMed	PTHR10183:SF381	CALPAIN-6
P00010	B cell activation	P00391	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00021	FGF signaling pathway	P00642	MEK1-2	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00034	Integrin signalling pathway	P00922	Collagen	MOUSE|MGI=MGI=88445|UniProtKB=Q05306	Collagen alpha-1(X) chain	IDA	10778855	PubMed	PTHR44057:SF5	COLLAGEN ALPHA-1 X  CHAIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ORYSJ|EnsemblGenome=OS03G0718100|UniProtKB=Q10DV7	Actin-1	IC	10974003	PubMed	PTHR11937:SF364	ACTIN-11
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	IDA	3045562	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P02754	Methylcitrate cycle	P03028	Aconitase	ARATH|TAIR=AT4G26970|UniProtKB=Q94A28	Aconitate hydratase 3, mitochondrial	ISS			PTHR11670:SF1	ACONITATE HYDRATASE
P00017	DNA replication	P00538	RNase H	RAT|RGD=1309012|UniProtKB=Q5BK46	Ribonuclease H1	ISS	12667461	PubMed	PTHR10642:SF0	RIBONUCLEASE H1
P00021	FGF signaling pathway	P00648	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P04371	5-Hydroxytryptamine biosynthesis	P04400	Aromatic L-amino acid decarboxylase	ORYSJ|EnsemblGenome=OS10G0380800|UniProtKB=Q7G6M2	Os10g0380800 protein	ISS			PTHR11999:SF141	SUBFAMILY NOT NAMED
P05915	Opioid proenkephalin pathway	P05993	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DROME|FlyBase=FBgn0259680|UniProtKB=P83099	Putative protein kinase C delta type homolog	ISS	15572354	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04393	Ras Pathway	P04567	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00402	Jnk	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IDA	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00034	Integrin signalling pathway	P00941	Integrin alpha	MOUSE|MGI=MGI=96603|UniProtKB=Q00651	Integrin alpha-4	IPI	11035110	PubMed	PTHR23220:SF78	INTEGRIN ALPHA-4
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	ORNAN|Ensembl=ENSOANG00000006811|UniProtKB=F6WBD5	Uncharacterized protein	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00029	Huntington disease	P00780	Microtubule	HUMAN|HGNC=20771|UniProtKB=P68371	Tubulin beta-4B chain	IDA	12932731	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P05915	Opioid proenkephalin pathway	P05994	G-protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00048	PI3 kinase pathway	P01188	Gbetagamma	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	10644715	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P02781	Threonine biosynthesis	P03190	Threonine synthase	MOUSE|MGI=MGI=2139347|UniProtKB=Q8BH55	Threonine synthase-like 1	ISS			PTHR43515:SF1	THREONINE SYNTHASE-LIKE 1
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00048	PI3 kinase pathway	P01178	Grb2	CAEEL|WormBase=WBGene00004774|UniProtKB=P29355	Sex muscle abnormal protein 5	TAS	17569445	gi	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00021	FGF signaling pathway	P00643	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00049	Parkinson disease	P01236	Casein kinase II	HUMAN|HGNC=2459|UniProtKB=P19784	Casein kinase II subunit alpha'	IDA	10806215	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P04393	Ras Pathway	P04559	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04393	Ras Pathway	P04574	PLD	MACMU|Ensembl=ENSMMUG00000005666|UniProtKB=F6VWY6	Uncharacterized protein	ISS	15030398	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02775	Salvage pyrimidine ribonucleotides	P03156	CDP kinase	DROME|FlyBase=FBgn0022029|UniProtKB=Q8MQK4	Uridine kinase	ISS			PTHR10285:SF123	URIDINE KINASE
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01143	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00046	Oxidative stress response	P01138	MKK4	MONDO|Ensembl=ENSMODG00000008266|UniProtKB=F6Z879	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00589	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04567	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00642	MEK1-2	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MACMU|Ensembl=ENSMMUG00000023736|UniProtKB=F7G778	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P00025	Hedgehog signaling pathway	P00692	GSK3	CAEEL|WormBase=WBGene00008095|UniProtKB=Q93372	Uncharacterized protein	ISS			PTHR24057:SF20	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	HUMAN|HGNC=9996|UniProtKB=O43566	Regulator of G-protein signaling 14	IDA	8756726	PubMed	PTHR10845:SF179	REGULATOR OF G-PROTEIN SIGNALING 14
P00021	FGF signaling pathway	P00632	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00025	Hedgehog signaling pathway	P00689	Patched	HUMAN|HGNC=9585|UniProtKB=Q13635	Protein patched homolog 1	IDA	8647801	PubMed	PTHR10796:SF61	PROTEIN PATCHED HOMOLOG 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P06587	Nicotine pharmacodynamics pathway	P06608	DDC	MACMU|Ensembl=ENSMMUG00000019991|UniProtKB=F7FNW0	Aromatic-L-amino-acid decarboxylase	ISS	90339966	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	IC	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	DROME|FlyBase=FBgn0040506|UniProtKB=Q9VK50	ACXE	IGI			PTHR11920:SF338	ACXA, ISOFORM A-RELATED
P00006	Apoptosis signaling pathway	P00269	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01238	14-3-3	USTMA|Gene=UMAG_01366|UniProtKB=A0A0D1E7J2	Chromosome 2, whole genome shotgun sequence	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00047	PDGF signaling pathway	P01142	p90RSK	BOVIN|Ensembl=ENSBTAG00000002015|UniProtKB=G5E5T2	Uncharacterized protein	ISS	15632195	PubMed	PTHR24351:SF98	RIBOSOMAL PROTEIN S6 KINASE ALPHA-6
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	MACMU|Ensembl=ENSMMUG00000000893|UniProtKB=F6T7D0	Histone acetyltransferase p300	ISS			PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TRIAD|EnsemblGenome=TriadG35956|UniProtKB=Q7YTV5	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00045	Notch signaling pathway	G01541	E(spl)-C genes	DROME|FlyBase=FBgn0002734|UniProtKB=Q01071	Enhancer of split mdelta protein	TAS	14973298	PubMed	PTHR10985:SF12	ENHANCER OF SPLIT M3 PROTEIN-RELATED
P00048	PI3 kinase pathway	P01199	Galpha	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CHICK|Ensembl=ENSGALG00000002536|UniProtKB=Q5ZMT6	Uncharacterized protein	ISS			PTHR19957:SF36	SYNTAXIN-2
P04393	Ras Pathway	P04558	p38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IDA	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04393	Ras Pathway	P04557	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	DROME|FlyBase=FBgn0001991|UniProtKB=Q24270	Voltage-dependent calcium channel type D subunit alpha-1	IC	10514528	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00877	MLCK	CHICK|Gene=Mylk|UniProtKB=P11799	Myosin light chain kinase, smooth muscle	IDA	11157482	PubMed	PTHR45480:SF1	MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE
P00059	p53 pathway	P01486	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00552	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00839	SHIP	MOUSE|MGI=MGI=1333787|UniProtKB=Q6P549	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	ISS	12145149	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	ANOGA|EnsemblGenome=AGAP002355|UniProtKB=Q7QBX9	Glutamine synthetase	ISS			PTHR20852:SF57	GLUTAMINE SYNTHETASE 2 CYTOPLASMIC
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00060	Ubiquitin proteasome pathway	P01490	E3	HUMAN|HGNC=4914|UniProtKB=P61086	Ubiquitin-conjugating enzyme E2 K	ISS			PTHR44020:SF2	UBIQUITIN-CONJUGATING ENZYME E2 K
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10875333	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00859	NFkappaB	MOUSE|MGI=MGI=1099800|UniProtKB=Q9WTK5	Nuclear factor NF-kappa-B p100 subunit	IDA	12574369	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P02740	De novo pyrimidine ribonucleotides biosythesis	P02922	Orotate phosphoribosyltransferase	ECOLI|EcoGene=EG10808|UniProtKB=P0A7E3	Orotate phosphoribosyltransferase	ISS			PTHR19278:SF36	OROTATE PHOSPHORIBOSYLTRANSFERASE
P00005	Angiogenesis	P00203	Erk	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05731	GABA-B receptor II signaling	P05760	AC	CANLF|Ensembl=ENSCAFG00000001097|UniProtKB=E2RCX6	Uncharacterized protein	ISS	8163524	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MACMU|Ensembl=ENSMMUG00000017683|UniProtKB=F6UA63	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01159	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01435	SWI/SNF	MACMU|Ensembl=ENSMMUG00000016771|UniProtKB=F7DBH2	Uncharacterized protein	ISS	11532957	PubMed	PTHR13844:SF2	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D MEMBER 2
P00006	Apoptosis signaling pathway	P00318	PKCs	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	CANLF|Ensembl=ENSCAFG00000017647|UniProtKB=F1PHQ0	Clathrin heavy chain	ISS	9388255	PubMed	PTHR10292:SF7	CLATHRIN HEAVY CHAIN 1
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	ARATH|TAIR=AT3G01820|UniProtKB=Q8L7W7	Probable adenylate kinase 7, mitochondrial	ISS			PTHR23359:SF86	ADENYLATE KINASE 7, MITOCHONDRIAL-RELATED
P04398	p53 pathway feedback loops 2	P04665	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00183	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	8264585	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00015	Circadian clock system	G01503	per	DANRE|ZFIN=ZDB-GENE-000804-1|UniProtKB=F1RDZ4	Uncharacterized protein	ISS			PTHR11269:SF13	PERIOD CIRCADIAN PROTEIN HOMOLOG 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MACMU|Ensembl=ENSMMUG00000022111|UniProtKB=F7H7W3	Ribosomal protein S6 kinase	ISS	12213813	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00011	Blood coagulation	P00421	alpha1-antitrypsin	BOVIN|Ensembl=ENSBTAG00000018843|UniProtKB=P34955	Alpha-1-antiproteinase	ISS	112890	gi	PTHR11461:SF165	ALPHA-1-ANTITRYPSIN-RELATED
P00049	Parkinson disease	P01237	Complex I	MYCTU|EnsemblGenome=Rv3149|UniProtKB=P9WIV5	NADH-quinone oxidoreductase subunit E	ISS			PTHR10371:SF3	NADH DEHYDROGENASE  UBIQUINONE  FLAVOPROTEIN 2, MITOCHONDRIAL
P04393	Ras Pathway	P04570	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	IC	14698601	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P02785	Valine biosynthesis	P03215	Branched chain amino acid aminotransferase	DROME|FlyBase=FBgn0030482|UniProtKB=Q9VYD5	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF44	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MOUSE|MGI=MGI=1351342|UniProtKB=Q3UVX5	Metabotropic glutamate receptor 5	ISS	12488551	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00049	Parkinson disease	P01211	ERK	PANTR|Ensembl=ENSPTRG00000008867|UniProtKB=H2QCF3	Mitogen-activated protein kinase	ISS	15085193	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P05915	Opioid proenkephalin pathway	P05985	Mu or Delta receptor	MACMU|Ensembl=ENSMMUG00000009389|UniProtKB=F7HEV7	Uncharacterized protein	ISS	11259498	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00017	DNA replication	P00529	RFC	RAT|RGD=620619|UniProtKB=D3ZFT1	Protein Rfc1	RCA			PTHR23389:SF22	REPLICATION FACTOR C SUBUNIT 1
P00047	PDGF signaling pathway	P01151	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	HUMAN|HGNC=11364|UniProtKB=P40763	Signal transducer and activator of transcription 3	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00010	B cell activation	P00397	IKK	MOUSE|MGI=MGI=1338071|UniProtKB=O88351	Inhibitor of nuclear factor kappa-B kinase subunit beta	IGI	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00049	Parkinson disease	P01230	Src kinase	HUMAN|HGNC=1057|UniProtKB=P51451	Tyrosine-protein kinase Blk	IDA	11078745	PubMed	PTHR24418:SF181	TYROSINE-PROTEIN KINASE BLK
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	XENTR|Xenbase=XB-GENE-483455|UniProtKB=Q0IHM5	Receptor protein serine/threonine kinase	ISS			PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	HUMAN|HGNC=11364|UniProtKB=P40763	Signal transducer and activator of transcription 3	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=1298406|UniProtKB=O88689	Protocadherin alpha-4	IDA	8120095	PubMed	PTHR24028:SF82	PROTOCADHERIN ALPHA-4
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00054	Toll receptor signaling pathway	P01375	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CANLF|Ensembl=ENSCAFG00000028654|UniProtKB=J9P702	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00048	PI3 kinase pathway	P01179	PKB	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	RCA	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00590	IP3 R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12880387	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	HUMAN|HGNC=4588|UniProtKB=O15399	Glutamate receptor ionotropic, NMDA 2D	IC	11554549	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MOUSE|MGI=MGI=1343142|UniProtKB=Q9WV32	Actin-related protein 2/3 complex subunit 1B	ISS	12473693	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	HUMAN|HGNC=10934|UniProtKB=P54219	Chromaffin granule amine transporter	ISS	12135927	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000019277|UniProtKB=H2QUQ1	Uncharacterized protein	ISS	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00018	EGF receptor signaling pathway	P00564	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00005	Angiogenesis	P00186	FGFR-1	CANLF|Ensembl=ENSCAFG00000005970|UniProtKB=E2R186	Fibroblast growth factor receptor	ISS	1708247	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	DANRE|ZFIN=ZDB-GENE-010406-5|UniProtKB=A2BGQ1	Uncharacterized protein	ISS			PTHR22778:SF37	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01451	Galpha	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00010	B cell activation	P00383	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	MOUSE|MGI=MGI=95739|UniProtKB=P15105	Glutamine synthetase	ISS			PTHR20852:SF45	GLUTAMINE SYNTHETASE
P00029	Huntington disease	P00799	JNK-2	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MOUSE|MGI=MGI=102522|UniProtKB=Q8R3Z5	Voltage-dependent L-type calcium channel subunit beta-1	ISS	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00036	Interleukin signaling pathway	P00977	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	NEUCR|EnsemblGenome=EFNCRG00000006613|UniProtKB=Q86ZF9	Glutamine synthetase	ISS			PTHR20852:SF57	GLUTAMINE SYNTHETASE 2 CYTOPLASMIC
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	MOUSE|MGI=MGI=2150393|UniProtKB=Q91ZU9	Glutamate receptor ionotropic, NMDA 3B	ISS	14698601	PubMed	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P04393	Ras Pathway	P04551	RalGDS	MOUSE|MGI=MGI=107483|UniProtKB=Q61193	Ral guanine nucleotide dissociation stimulator-like 2	ISS	8939933	PubMed	PTHR23113:SF213	RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 2
P00029	Huntington disease	P00786	ARF	PHYPA|Gene=PHYPADRAFT_193635|UniProtKB=A9TBY8	Predicted protein	ISS	12932731	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00029	Huntington disease	P00778	NMDA receptor	XENTR|Xenbase=XB-GENE-494200|UniProtKB=F7CS79	Uncharacterized protein	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04392	P53 pathway feedback loops 1	G04682	MDM-2	CANLF|Ensembl=ENSCAFG00000009669|UniProtKB=E2RDT3	Uncharacterized protein	ISS			PTHR13844:SF20	PROTEIN MDM4
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01192	p110	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00034	Integrin signalling pathway	P00931	Integrin beta	BOVIN|Ensembl=ENSBTAG00000009987|UniProtKB=F1MTN1	Integrin beta	ISS	5805343	gi	PTHR10082:SF25	INTEGRIN BETA-3
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	THEMA|EnsemblGenome=TM_0148|UniProtKB=Q9WXZ5	Glutamine--fructose-6-phosphate aminotransferase [isomerizing]	ISS			PTHR10937:SF0	GH12731P-RELATED
P00029	Huntington disease	P00807	Actin	DICPU|Gene=DICPUDRAFT_46519|UniProtKB=F0Z796	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00059	p53 pathway	G04701	PML	MOUSE|MGI=MGI=104662|UniProtKB=Q60953	Protein PML	ISS			PTHR45211:SF1	PROTEIN PML
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IGI	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01443	Phospholipase C	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00036	Interleukin signaling pathway	P00970	Interleukin	RAT|RGD=2889|UniProtKB=P97636	Interleukin-18	IGI	9702748	PubMed	PTHR45200:SF1	INTERLEUKIN-18
P00034	Integrin signalling pathway	P00920	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00046	Oxidative stress response	P01125	Stat1	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	12191995	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00005	Angiogenesis	P00186	FGFR-1	ORNAN|Ensembl=ENSOANG00000003252|UniProtKB=F6SM70	Fibroblast growth factor receptor	ISS	1708247	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	BOVIN|Gene=MYH2|UniProtKB=Q9BE41	Myosin-2	IC	89264452	PubMed	PTHR13140:SF385	MYOSIN-2
P00010	B cell activation	P00391	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00013	Cell cycle	P00480	Proteasome	TRYB2|Gene=Tb927.2.2440|UniProtKB=Q586L6	Proteasome regulatory non-ATPase subunit 6	ISS	12213827	PubMed	PTHR10678:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00060	Ubiquitin proteasome pathway	P01491	E2	CANLF|Ensembl=ENSCAFG00000014163|UniProtKB=E2RHN3	Uncharacterized protein	ISS			PTHR24068:SF63	UBIQUITIN-CONJUGATING ENZYME E2 E3
P00048	PI3 kinase pathway	P01199	Galpha	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02783	Tryptophan biosynthesis	P03210	Indole-3-glycerol phosphate synthase	ARATH|TAIR=AT5G48220|UniProtKB=Q9LUB2	AT5g48220/MIF21_11	ISS			PTHR22854:SF10	INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE, CHLOROPLASTIC
P00034	Integrin signalling pathway	P00944	Actin	BOVIN|Ensembl=ENSBTAG00000005714|UniProtKB=Q3ZC07	Actin, alpha cardiac muscle 1	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00029	Huntington disease	G01535	PIG3	MACMU|Ensembl=ENSMMUG00000014593|UniProtKB=F7GW27	Quinone oxidoreductase isoform a	ISS	12932731	PubMed	PTHR44154:SF1	QUINONE OXIDOREDUCTASE
P00048	PI3 kinase pathway	P01177	P110ACT	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00057	Wnt signaling pathway	P01446	Calcineurin	HUMAN|HGNC=9314|UniProtKB=Q08209	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	IDA	12015605	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01080	AChE	CAEEL|WormBase=WBGene00000037|UniProtKB=Q9U295	Carboxylic ester hydrolase	IC			PTHR43918:SF5	CHOLINESTERASE
P00034	Integrin signalling pathway	P00941	Integrin alpha	CANLF|Ensembl=ENSCAFG00000004820|UniProtKB=J9NYD7	Uncharacterized protein	ISS	3487386	PubMed	PTHR23220:SF69	INTEGRIN ALPHA-9
P00011	Blood coagulation	P00455	GP IX	MOUSE|MGI=MGI=1860137|UniProtKB=O88186	Platelet glycoprotein IX	IDA	98353120	PubMed	PTHR22650:SF6	PLATELET GLYCOPROTEIN IX
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	ISS	9166716	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00006	Apoptosis signaling pathway	P00311	GCKR	HUMAN|HGNC=6866|UniProtKB=O95819	Mitogen-activated protein kinase kinase kinase kinase 4	RCA			PTHR24361:SF225	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 4
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	IC	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	TAS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01194	S6K	CANLF|Ensembl=ENSCAFG00000011590|UniProtKB=E2R7K9	Ribosomal protein S6 kinase	ISS	15116068	PubMed	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	MACMU|Ensembl=ENSMMUG00000012305|UniProtKB=F7DLC9	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00059	p53 pathway	P04633	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PANTR|Ensembl=ENSPTRG00000018890|UniProtKB=Q5R1X3	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P02763	Peptidoglycan biosynthesis	P03083	UDP-N-acetylmuramoylalanine-D-glutamate ligase	STRCO|EnsemblGenome=CAB51995|UniProtKB=Q9S2W9	UDP-N-acetylmuramoylalanine--D-glutamate ligase	ISS			PTHR43692:SF1	UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	TAKRU|Ensembl=ENSTRUG00000015213|UniProtKB=H2UPJ1	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF356	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00060	Ubiquitin proteasome pathway	P01490	E3	PANTR|Ensembl=ENSPTRG00000019919|UniProtKB=H2QVP1	Ubiquitin protein ligase E3C	ISS			PTHR11254:SF357	UBIQUITIN-PROTEIN LIGASE E3C
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000008719|UniProtKB=F1MZX0	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00019	Endothelin signaling pathway	P00566	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00025	Hedgehog signaling pathway	P00685	Smoothened	RAT|RGD=3726|UniProtKB=P97698	Smoothened homolog	ISS	942251	PubMed	PTHR11309:SF35	SMOOTHENED HOMOLOG
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MOUSE|MGI=MGI=2150393|UniProtKB=Q91ZU9	Glutamate receptor ionotropic, NMDA 3B	IC	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P00021	FGF signaling pathway	P00648	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	IGI	11591316	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P02771	Pyrimidine Metabolism	P03124	Methylmalonate Semialdehyde Dehydrogenase	STRCO|Gene=CAB75315|UniProtKB=Q9L1J1	Methylmalonic acid semialdehyde dehydrogenase	ISS	8550471	PubMed	PTHR43866:SF4	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00590	IP3 R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00906	Rap1	ORNAN|Ensembl=ENSOANG00000005936|UniProtKB=F6PQC9	Uncharacterized protein	ISS	8576107	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00010	B cell activation	P00373	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04585	TRH	RAT|RGD=3910|UniProtKB=P04652	Thyrotropin subunit beta	ISS			PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	HUMAN|HGNC=129|UniProtKB=P68133	Actin, alpha skeletal muscle	IEP	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P05730	Endogenous cannabinoid signaling	P05748	mGluR	HUMAN|HGNC=4597|UniProtKB=P41594	Metabotropic glutamate receptor 5	ISS	12351712	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MACMU|Ensembl=ENSMMUG00000009679|UniProtKB=F6YBQ8	Uncharacterized protein	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P02784	Tyrosine biosynthesis	P03213	Aromatic amino acid aminotransferase	ARATH|TAIR=AT4G28420|UniProtKB=Q67Y55	Probable aminotransferase TAT1	ISS			PTHR11751:SF368	TYROSINE AMINOTRANSFERASE
P00019	Endothelin signaling pathway	P00568	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	IGI	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	HUMAN|HGNC=1402|UniProtKB=Q08289	Voltage-dependent L-type calcium channel subunit beta-2	IC	20088160	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00005	Angiogenesis	P00203	Erk	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01227	20S proteasome	DROME|FlyBase=FBgn0026380|UniProtKB=Q9XYN7	Proteasome subunit beta type-3	TAS	12859888	PubMed	PTHR11599:SF62	PROTEASOME SUBUNIT BETA TYPE-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IDA	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	RAT|RGD=70964|UniProtKB=Q62893	Anti-Muellerian hormone type-2 receptor	TAS	9395284	PubMed	PTHR23255:SF49	ANTI-MUELLERIAN HORMONE TYPE-2 RECEPTOR
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	BOVIN|Ensembl=ENSBTAG00000017147|UniProtKB=P08760	GTP:AMP phosphotransferase AK3, mitochondrial	ISS			PTHR23359:SF68	GTP:AMP PHOSPHOTRANSFERASE AK3, MITOCHONDRIAL
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	RAT|RGD=61985|UniProtKB=Q62833	G protein-coupled receptor kinase 5	IDA	8288567	PubMed	PTHR24355:SF27	G PROTEIN-COUPLED RECEPTOR KINASE 5
P00034	Integrin signalling pathway	P00931	Integrin beta	HUMAN|HGNC=6153|UniProtKB=P05556	Integrin beta-1	IDA	3487386	PubMed	PTHR10082:SF28	INTEGRIN BETA-1
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00048	PI3 kinase pathway	P01177	P110ACT	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00920	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000008751|UniProtKB=H2QC89	Uncharacterized protein	ISS	129387	gi	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00583	cPLA2	BOVIN|Ensembl=ENSBTAG00000013298|UniProtKB=A4IFJ5	Cytosolic phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	TAKRU|Ensembl=ENSTRUG00000018612|UniProtKB=H2VEM3	Protein-serine/threonine kinase	ISS	10852916	PubMed	PTHR24355:SF18	PROTEIN-SERINE/THREONINE KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	DAPPU|EnsemblGenome=DAPPUDRAFT_300845|UniProtKB=E9HEX5	Putative uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF250	SUBFAMILY NOT NAMED
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	TAKRU|Ensembl=ENSTRUG00000015631|UniProtKB=H2USP0	Uncharacterized protein	ISS			PTHR11681:SF14	SUBFAMILY NOT NAMED
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	CANLF|Ensembl=ENSCAFG00000013067|UniProtKB=E2RJA0	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00627	ERK1-2	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04567	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04546	GSK3	BOVIN|Ensembl=ENSBTAG00000020756|UniProtKB=A6QLB8	GSK3A protein	ISS	12086949	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	RAT|RGD=3380|UniProtKB=P63331	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00807	Actin	ARATH|TAIR=AT2G42090|UniProtKB=P93738	Putative actin-9	IDA	14684598	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P02776	Serine glycine biosynthesis	P03160	Phosphoglycerate dehydrogenase	PANTR|Gene=PHGDH|UniProtKB=A5A6P1	D-3-phosphoglycerate dehydrogenase	ISS			PTHR42938:SF5	D-3-PHOSPHOGLYCERATE DEHYDROGENASE
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01208	Hsp70	CAEBR|Gene=CBG13234|UniProtKB=A8XHD1	Protein CBG13234	ISS	12150907	PubMed	PTHR19375:SF256	HSP70 PROTEIN-RELATED
P00049	Parkinson disease	P01230	Src kinase	MACMU|Ensembl=ENSMMUG00000020131|UniProtKB=F7FWN4	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	IDA	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00464	Fyn	CHICK|Gene=FYN|UniProtKB=Q05876	Tyrosine-protein kinase Fyn	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00048	PI3 kinase pathway	P01188	Gbetagamma	MOUSE|MGI=MGI=101848|UniProtKB=P62881	Guanine nucleotide-binding protein subunit beta-5	IC	9754712	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00005	Angiogenesis	P00231	HSP27	BOVIN|Ensembl=ENSBTAG00000003134|UniProtKB=P02470	Alpha-crystallin A chain	ISS			PTHR11527:SF36	ALPHA-CRYSTALLIN A CHAIN
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00572	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01451	Galpha	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00572	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IGI	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12912997	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00067	MAO	CANLF|Ensembl=ENSCAFG00000014435|UniProtKB=P58027	Amine oxidase [flavin-containing] A	ISS	90344230	PubMed	PTHR43563:SF3	AMINE OXIDASE  FLAVIN-CONTAINING  A
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00021	FGF signaling pathway	P00638	PLCgamma	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00012	Cadherin signaling pathway	P00475	Frizzled	MONDO|Ensembl=ENSMODG00000011428|UniProtKB=F6RKF7	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF34	FRIZZLED-2
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	MOUSE|MGI=MGI=94925|UniProtKB=P30728	D(3) dopamine receptor	RCA	2137198	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ARATH|TAIR=AT1G10210|UniProtKB=Q39021	Mitogen-activated protein kinase 1	IDA			PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00029	Huntington disease	P00801	Fos protein	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	TAS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00747	Rhodopsin	DROME|FlyBase=FBgn0002940|UniProtKB=P06002	Opsin Rh1	IDA	1634520	PubMed	PTHR24240:SF85	OPSIN RH1-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00049	Parkinson disease	P01238	14-3-3	HUMAN|HGNC=12851|UniProtKB=P62258	14-3-3 protein epsilon	ISS	98119747	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00470	F-actin	ARATH|TAIR=AT5G59370|UniProtKB=P53494	Actin-4	IC	11889126	PubMed	PTHR11937:SF366	ACTIN-4
P04398	p53 pathway feedback loops 2	P04665	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04396	Vitamin D metabolism and pathway	P04602	RXR	DANRE|ZFIN=ZDB-GENE-980526-284|UniProtKB=Q90271	Retinoic acid receptor alpha-A	ISS			PTHR24082:SF115	RETINOIC ACID RECEPTOR ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000022936|UniProtKB=F6U709	Uncharacterized protein	ISS	11248120	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	CANLF|Ensembl=ENSCAFG00000018564|UniProtKB=E2RHU1	Uncharacterized protein	ISS	20112749	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	PANTR|Ensembl=ENSPTRG00000002979|UniProtKB=H2Q2M8	Uncharacterized protein	ISS	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00049	Parkinson disease	P01227	20S proteasome	DICDI|dictyBase=DDB_G0272831|UniProtKB=P34120	Proteasome subunit alpha type-7	TAS	12859888	PubMed	PTHR11599:SF15	PROTEASOME SUBUNIT ALPHA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9060|UniProtKB=P51178	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	10934033	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	BOVIN|Ensembl=ENSBTAG00000000469|UniProtKB=P67774	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01456	beta-arrestin	PANTR|Ensembl=ENSPTRG00000004079|UniProtKB=H2R1Z2	Uncharacterized protein	ISS	9388255	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	SCHPO|PomBase=SPAC29E6.08|UniProtKB=P17871	TATA-box-binding protein	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CAEEL|WormBase=WBGene00001745|UniProtKB=Q7KPV0	G protein, Subunit Alpha	IC	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00029	Huntington disease	P00778	NMDA receptor	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	ARATH|TAIR=AT3G55940|UniProtKB=Q9LY51	Phosphoinositide phospholipase C 7	ISS			PTHR10336:SF92	PHOSPHOINOSITIDE PHOSPHOLIPASE C 2-RELATED
P00015	Circadian clock system	G01497	cry	DANRE|ZFIN=ZDB-GENE-010426-4|UniProtKB=B0S7X5	Uncharacterized protein	ISS			PTHR11455:SF10	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00966	mTOR	TAKRU|Ensembl=ENSTRUG00000009031|UniProtKB=H2TDG4	Uncharacterized protein	ISS			PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P02781	Threonine biosynthesis	P03190	Threonine synthase	SCHPO|PomBase=SPAC9E9.06c|UniProtKB=Q42598	Threonine synthase	ISS	11859360	PubMed	PTHR42690:SF1	THREONINE SYNTHASE-LIKE 2
P00052	TGF-beta signaling pathway	P01286	TGFbeta	CANLF|Ensembl=ENSCAFG00000014880|UniProtKB=F1PDL1	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF165	BONE MORPHOGENETIC PROTEIN 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00034	Integrin signalling pathway	P00936	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	IPI	10799299	PubMed	PTHR10048:SF14	PI-3 KINASE
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1718748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	PANTR|Ensembl=ENSPTRG00000001789|UniProtKB=H2Q0T2	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF155	REGULATOR OF G-PROTEIN SIGNALING 18
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	MACMU|Ensembl=ENSMMUG00000001387|UniProtKB=F7D0B4	Uncharacterized protein	ISS	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00020	FAS signaling pathway	P00620	CytochromeC	PANTR|Ensembl=ENSPTRG00000020679|UniProtKB=H2QWV8	Cytochrome c-1	ISS	15163634	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P06664	Gonadotropin-releasing hormone receptor pathway	P06759	IRS	MOUSE|MGI=MGI=1194882|UniProtKB=O54718	Insulin receptor substrate 3, isoform CRA_a (Fragment)	RCA	5031805	gi	PTHR10614:SF8	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00012	Cadherin signaling pathway	P00475	Frizzled	PANTR|Ensembl=ENSPTRG00000004148|UniProtKB=H2Q4I6	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF23	FRIZZLED-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	BOVIN|Ensembl=ENSBTAG00000014710|UniProtKB=P62833	Ras-related protein Rap-1A	ISS	10476970	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00005	Angiogenesis	P00208	MEKK1	BOVIN|Ensembl=ENSBTAG00000013790|UniProtKB=E1B847	Uncharacterized protein	ISS	8940199	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02773	S-adenosylmethionine biosynthesis	P03142	Cobalamin-dependent homocysteine transmethylase	BACSU|EnsemblGenome=BSU11010|UniProtKB=O06745	Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase	ISS			PTHR21091:SF166	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04661	PI3K	DROME|FlyBase=FBgn0015277|UniProtKB=Q9W1M7	Phosphatidylinositol 3-kinase	ISS			PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00034	Integrin signalling pathway	P00929	C3G	DROME|FlyBase=FBgn0259228|UniProtKB=O77086	Guanine nucleotide-releasing factor 2	IPI	10777617	PubMed	PTHR23113:SF224	RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00020	FAS signaling pathway	P00608	Pro-Caspase3	MOUSE|MGI=MGI=107739|UniProtKB=P70677	Caspase-3	ISS	11675509	PubMed	PTHR10454:SF198	CASPASE-3
P00036	Interleukin signaling pathway	P00965	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	IC	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MACMU|Ensembl=ENSMMUG00000017374|UniProtKB=F7H6T7	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05913	Enkephalin release	P05974	G-Protein (i)	ORNAN|Ensembl=ENSOANG00000003489|UniProtKB=F7FSE3	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CAEEL|WormBase=WBGene00004055|UniProtKB=Q17446	Mitogen-activated protein kinase pmk-1	IDA	11703092	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00046	Oxidative stress response	P01129	JNK1/2	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	HUMAN|HGNC=9508|UniProtKB=P49768	Presenilin-1	TAS	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P00018	EGF receptor signaling pathway	P00564	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00021	FGF signaling pathway	P00644	p38	DANRE|ZFIN=ZDB-GENE-990415-257|UniProtKB=O42376	Mitogen-activated protein kinase 12	ISS	11707292	PubMed	PTHR24055:SF339	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00709	Glycogen synthase D	MONDO|Ensembl=ENSMODG00000017796|UniProtKB=F7CFJ9	Uncharacterized protein	ISS	4212312	PubMed	PTHR10176:SF1	GLYCOGEN  STARCH  SYNTHASE, LIVER
P00018	EGF receptor signaling pathway	P00539	14-3-3	ARATH|TAIR=AT1G78300|UniProtKB=Q01525	14-3-3-like protein GF14 omega	ISS	10407019	PubMed	PTHR18860:SF26	14-3-3 FAMILY PROTEIN-RELATED
P00021	FGF signaling pathway	P00631	Grb2	BOVIN|Ensembl=ENSBTAG00000003707|UniProtKB=A6QLK6	GRB2-related adapter protein	ISS	8647802	PubMed	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01153	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=88354|UniProtKB=P09803	Cadherin-1	IDA	11953314	PubMed	PTHR24027:SF319	CADHERIN-1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00049	Parkinson disease	P01219	SAPK	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00892	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12748278	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05731	GABA-B receptor II signaling	P05753	Ca channel	HUMAN|HGNC=1388|UniProtKB=O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	11976940	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00021	FGF signaling pathway	P00629	PP2A	PANTR|Ensembl=ENSPTRG00000015883|UniProtKB=H2QP63	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B	ISS	7918404	PubMed	PTHR11871:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B GAMMA ISOFORM
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1354946|UniProtKB=Q61532	Mitogen-activated protein kinase 6	ISS	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00012	Cadherin signaling pathway	P00477	GSK3beta	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00006	Apoptosis signaling pathway	P00313	IKK	PANTR|Ensembl=ENSPTRG00000020202|UniProtKB=H2QW34	Uncharacterized protein	ISS	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00025	Hedgehog signaling pathway	P00682	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00226	Delta/Serrate	MACMU|Ensembl=ENSMMUG00000020038|UniProtKB=F7GDI5	Uncharacterized protein	ISS			PTHR24052:SF11	PROTEIN DELTA HOMOLOG 1
P00037	Ionotropic glutamate receptor pathway	P01026	KA	PANTR|Ensembl=ENSPTRG00000000543|UniProtKB=H2PYN8	Uncharacterized protein	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DICDI|dictyBase=DDB_G0275023|UniProtKB=Q553U6	Putative actin-22	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	IC	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04393	Ras Pathway	P04572	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00024	Glycolysis	P00676	Glyceraldehyde 3-phosphate dehydrogenase	STRCO|Gene=CAC01538|UniProtKB=Q9FC43	Glyceraldehyde-3-phosphate dehydrogenase	ISS	8612237	PubMed	PTHR43454:SF1	SUBFAMILY NOT NAMED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04451	CRHR1	MOUSE|MGI=MGI=894312|UniProtKB=Q60748	Corticotropin-releasing factor receptor 2	ISS	11145609	PubMed	PTHR12011:SF274	CORTICOTROPIN-RELEASING FACTOR RECEPTOR 2
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	RAT|RGD=3805|UniProtKB=P40748	Synaptotagmin-3	RCA			PTHR10024:SF176	SYNAPTOTAGMIN-3
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	DANRE|ZFIN=ZDB-GENE-040426-1013|UniProtKB=Q6P0T2	Transcription initiation factor TFIID subunit 8	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00036	Interleukin signaling pathway	P00977	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MONDO|Ensembl=ENSMODG00000005623|UniProtKB=F7CFG8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P05913	Enkephalin release	P05972	PKA	DICDI|dictyBase=DDB_G0283907|UniProtKB=P34099	cAMP-dependent protein kinase catalytic subunit	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	MACMU|Ensembl=ENSMMUG00000000893|UniProtKB=F6T7D0	Histone acetyltransferase p300	ISS	8413673	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	CHICK|Ensembl=ENSGALG00000011452|UniProtKB=F1P1K3	Uncharacterized protein	ISS	10940259	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00047	PDGF signaling pathway	P01153	GSK3	PLAF7|EnsemblGenome=PFC0525c|UniProtKB=O77344	Glycogen synthase kinase 3	ISS	21361340	gi	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00006	Apoptosis signaling pathway	P00269	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00034	Integrin signalling pathway	P00931	Integrin beta	ORNAN|Ensembl=ENSOANG00000006060|UniProtKB=F6PNT9	Integrin beta	ISS	3487386	PubMed	PTHR10082:SF28	INTEGRIN BETA-1
P00018	EGF receptor signaling pathway	P00565	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00010	B cell activation	P00402	Jnk	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02723	Adenine and hypoxanthine salvage pathway	P02813	Inosine phosphorylase	HUMAN|HGNC=7892|UniProtKB=P00491	Purine nucleoside phosphorylase	ISS			PTHR11904:SF12	PURINE NUCLEOSIDE PHOSPHORYLASE
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	YEAST|SGD=S000001855|UniProtKB=P60010	Actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02759	Pyridoxal-5-phosphate biosynthesis	P03058	Phosphohydroxythreonine aminotransferase	SCHPO|PomBase=SPAC1F12.07|UniProtKB=Q10349	Putative phosphoserine aminotransferase	ISS			PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	HUMAN|HGNC=8568|UniProtKB=P09958	Furin	IDA	11861638	PubMed	PTHR42884:SF1	FURIN
P00010	B cell activation	P00383	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	IDA	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	TAKRU|Ensembl=ENSTRUG00000014798|UniProtKB=H2ULI5	Uncharacterized protein	ISS	12145413	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00048	PI3 kinase pathway	P01188	Gbetagamma	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00029	Huntington disease	P00807	Actin	HUMAN|HGNC=130|UniProtKB=P62736	Actin, aortic smooth muscle	IDA	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00005	Angiogenesis	P00244	MAPKAPK2/3	MOUSE|MGI=MGI=109298|UniProtKB=P49138	MAP kinase-activated protein kinase 2	ISS	9628873	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00021	FGF signaling pathway	P00647	SHP2	HUMAN|HGNC=9658|UniProtKB=P29350	Tyrosine-protein phosphatase non-receptor type 6	ISS	14525967	PubMed	PTHR19134:SF65	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 6
P00019	Endothelin signaling pathway	P00566	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00049	Parkinson disease	P01219	SAPK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	NAS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00046	Oxidative stress response	P01129	JNK1/2	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	HUMAN|HGNC=236|UniProtKB=O95622	Adenylate cyclase type 5	IC	94139935	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	IXOSC|EnsemblGenome=ISCW016027|UniProtKB=B7P674	CTP synthase	ISS			PTHR11550:SF0	CTP SYNTHASE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00047	PDGF signaling pathway	P01150	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00005	Angiogenesis	P00249	PAK	MOUSE|MGI=MGI=1339975|UniProtKB=O88643	Serine/threonine-protein kinase PAK 1	ISS	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00046	Oxidative stress response	P01126	ATF2	PANTR|Ensembl=ENSPTRG00000012660|UniProtKB=H2QJ07	Activating transcription factor 2	ISS	9819389	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CAEBR|Gene=CBG04190|UniProtKB=A8WWD7	Protein CBR-MEK-2	ISS	22022015	PubMed	PTHR24361:SF629	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1
P04393	Ras Pathway	P04552	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00059	p53 pathway	G04694	p110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	IDA	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IDA	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00051	TCA cycle	P01273	Succinate Dehydrogenase	BOVIN|Ensembl=ENSBTAG00000015853|UniProtKB=P35720	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	IDA	95034971	PubMed	PTHR10978:SF5	SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	HUMAN|HGNC=2455|UniProtKB=P78368	Casein kinase I isoform gamma-2	IDA	11437445	PubMed	PTHR11909:SF157	CASEIN KINASE I ISOFORM GAMMA-2
P05731	GABA-B receptor II signaling	P05756	GABA-B receptor	CANLF|Ensembl=ENSCAFG00000002487|UniProtKB=E2R738	Uncharacterized protein	ISS	9872315	PubMed	PTHR10519:SF62	GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DROME|FlyBase=FBgn0001122|UniProtKB=P16378	G protein alpha o subunit	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P05916	Opioid prodynorphin pathway	P06000	vasopressin	MACMU|Ensembl=ENSMMUG00000010678|UniProtKB=F7AXI7	Uncharacterized protein	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00056	VEGF signaling pathway	P01417	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05912	Dopamine receptor mediated signaling pathway	P05961	DOPA decarb.	RAT|RGD=2494|UniProtKB=P14173	Aromatic-L-amino-acid decarboxylase	ISS	107930	OMIM	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00048	PI3 kinase pathway	P01206	14-3-3	CAEBR|Gene=CBG17289|UniProtKB=A8XQR9	14-3-3 zeta	ISS	10407019	PubMed	PTHR18860:SF13	14-3-3 PROTEIN ZETA
P04398	p53 pathway feedback loops 2	P04651	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	PANTR|Ensembl=ENSPTRG00000014976|UniProtKB=H2R892	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	CHICK|Ensembl=ENSGALG00000017238|UniProtKB=F1NWG3	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	IDA	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00045	Notch signaling pathway	P01099	Notch	RAT|RGD=620761|UniProtKB=Q9R172	Neurogenic locus notch homolog protein 3	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	BOVIN|Ensembl=ENSBTAG00000013874|UniProtKB=Q6B857	Cilia- and flagella-associated protein 20	ISS			PTHR12458:SF8	CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20
P02755	Methylmalonyl pathway	P03034	Methylmalonyl-CoA mutase	STRCO|Gene=CAC17657|UniProtKB=Q9EWD8	Methylmalonyl CoA mutase	ISS			PTHR43589:SF3	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	HUMAN|HGNC=16767|UniProtKB=Q8TCU5	Glutamate receptor ionotropic, NMDA 3A	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04397	p53 pathway by glucose deprivation	P04636	S6K	MACMU|Ensembl=ENSMMUG00000019305|UniProtKB=F6S3T8	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PHYPA|Gene=PHYPADRAFT_109052|UniProtKB=A9TZ58	Actin 5	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00012	Cadherin signaling pathway	P00474	Wnt	BOVIN|Ensembl=ENSBTAG00000020267|UniProtKB=F1MKX1	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P00057	Wnt signaling pathway	P01435	SWI/SNF	HUMAN|HGNC=11105|UniProtKB=Q8TAQ2	SWI/SNF complex subunit SMARCC2	IDA	11532957	PubMed	PTHR12802:SF38	SWI/SNF COMPLEX SUBUNIT SMARCC2
P05731	GABA-B receptor II signaling	P05754	Ggamma	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00046	Oxidative stress response	P01135	p38	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	TAS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00029	Huntington disease	P00796	Kainate receptor	MOUSE|MGI=MGI=95817|UniProtKB=Q8BMF5	Glutamate receptor ionotropic, kainate 4	ISS	12871085	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	ISS	10571227	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9062|UniProtKB=Q9BRC7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	7822322	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CAEEL|WormBase=WBGene00000067|UniProtKB=O45815	ACTin	IC	14684598	PubMed	PTHR11937:SF352	ACTIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=894282|UniProtKB=O08858	Somatostatin receptor type 5	IDA	12441358	PubMed	PTHR24229:SF20	SOMATOSTATIN RECEPTOR TYPE 5
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00875	GEF	CANLF|Ensembl=ENSCAFG00000010948|UniProtKB=J9NRL7	Uncharacterized protein	ISS	11955434	PubMed	PTHR22829:SF6	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE-DEPENDENT RAC EXCHANGER 1 PROTEIN
P00030	Hypoxia response via HIF activation	P00823	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00983	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00036	Interleukin signaling pathway	P00973	PKB	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	DROME|FlyBase=FBgn0263111|UniProtKB=P91645	Voltage-dependent calcium channel type A subunit alpha-1	ISS	14507926	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P00005	Angiogenesis	P00223	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12539654	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04397	p53 pathway by glucose deprivation	P04640	p53	DANRE|ZFIN=ZDB-GENE-030819-1|UniProtKB=E9QG65	Uncharacterized protein	TAS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00019	Endothelin signaling pathway	P00591	PLCbeta	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00012	Cadherin signaling pathway	P00471	Cadherin	BOVIN|Ensembl=ENSBTAG00000015405|UniProtKB=E1B969	Uncharacterized protein	ISS	8120095	PubMed	PTHR43956:SF6	PROTOCADHERIN-16
P00005	Angiogenesis	P00237	FRP	MACMU|Ensembl=ENSMMUG00000022114|UniProtKB=F7H7V5	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF81	FRIZZLED-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	IDA	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00021	FGF signaling pathway	P00627	ERK1-2	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IGI	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00542	EGFR	PANTR|Ensembl=ENSPTRG00000019196|UniProtKB=H2QUL1	Receptor protein-tyrosine kinase	ISS	90258888	PubMed	PTHR24416:SF91	EPIDERMAL GROWTH FACTOR RECEPTOR
P00018	EGF receptor signaling pathway	P00547	PP2A	SCHPO|PomBase=SPAC6F12.12|UniProtKB=P78759	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta 2 isoform	ISS	10092233	PubMed	PTHR10257:SF3	PP2A-B', ISOFORM B
P05912	Dopamine receptor mediated signaling pathway	P05961	DOPA decarb.	MACMU|Ensembl=ENSMMUG00000019991|UniProtKB=F7FNW0	Aromatic-L-amino-acid decarboxylase	ISS	90339966	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	TAS	20451058	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00047	PDGF signaling pathway	P01173	STAT	RAT|RGD=3772|UniProtKB=P52631	Signal transducer and activator of transcription 3	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00048	PI3 kinase pathway	P01185	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PHYIT|EnsemblGenome=PITG_15117|UniProtKB=D0NRP9	Actin-like protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00059	p53 pathway	G04694	p110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	PANTR|Ensembl=ENSPTRG00000000547|UniProtKB=H2PYP1	Smad nuclear interacting protein 1	ISS	10400677	PubMed	PTHR23308:SF36	SMAD NUCLEAR-INTERACTING PROTEIN 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	CHICK|Ensembl=ENSGALG00000001383|UniProtKB=F1NJL4	Uncharacterized protein	ISS	12898568	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P02783	Tryptophan biosynthesis	P03207	Tryptophan synthase A	STRCO|EnsemblGenome=CAB51428|UniProtKB=O68816	Tryptophan synthase alpha chain	ISS			PTHR10314:SF8	CYSTATHIONINE BETA-SYNTHASE-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	TAKRU|Ensembl=ENSTRUG00000015938|UniProtKB=H2UUX5	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00539	14-3-3	BOVIN|Ensembl=ENSBTAG00000005664|UniProtKB=P62261	14-3-3 protein epsilon	ISS	9450960	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=2683547|UniProtKB=Q4KWH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1	ISS	10934033	PubMed	PTHR10336:SF51	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BOVIN|Ensembl=ENSBTAG00000006189|UniProtKB=P63258	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00005	Angiogenesis	P00221	JNK1	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	ISS	10207617	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	ARATH|TAIR=AT5G46860|UniProtKB=P93654	Syntaxin-22	IC			PTHR19957:SF38	T-SNARE DOMAIN-CONTAINING PROTEIN 1
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	LEIMA|EnsemblGenome=LmjF.35.4010|UniProtKB=Q9GNR4	Protein kinase A catalytic subunit isoform 1	ISS	10218114	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	CANLF|Ensembl=ENSCAFG00000004930|UniProtKB=E2RFB5	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P02738	De novo purine biosynthesis	P02907	dADP kinase	CANLF|Ensembl=ENSCAFG00000030883|UniProtKB=J9NSB4	Nucleoside diphosphate kinase	ISS			PTHR11349:SF70	NUCLEOSIDE DIPHOSPHATE KINASE 6
P00005	Angiogenesis	P00203	Erk	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00554	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	7798194	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04398	p53 pathway feedback loops 2	P04657	P110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IGI	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00019	Endothelin signaling pathway	P00566	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	21071228	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00019	Endothelin signaling pathway	P00566	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	TAKRU|Ensembl=ENSTRUG00000010213|UniProtKB=H2TM14	Uncharacterized protein (Fragment)	ISS	85270494	PubMed	PTHR18945:SF401	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4
P00057	Wnt signaling pathway	P01438	PP2A	RAT|RGD=6503701|UniProtKB=F1MAA3	Protein LOC100909464	ISS	12110603	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P04393	Ras Pathway	P04558	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	IDA	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00017	DNA replication	P00536	DNA Topisomerase	MACMU|Ensembl=ENSMMUG00000008941|UniProtKB=F7EVK2	DNA topoisomerase 2	ISS			PTHR10169:SF46	DNA TOPOISOMERASE 2-ALPHA
P00024	Glycolysis	P00678	Enolase	MOUSE|MGI=MGI=95393|UniProtKB=P17182	Alpha-enolase	ISS	89079778	PubMed	PTHR11902:SF12	ALPHA-ENOLASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	MOUSE|MGI=MGI=88399|UniProtKB=P32211	Muscarinic acetylcholine receptor M4	ISS	8100450	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00018	EGF receptor signaling pathway	P00558	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IGI	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05734	Synaptic vesicle trafficking	P05770	Munc18	ORNAN|Ensembl=ENSOANG00000002090|UniProtKB=F6UNB0	Uncharacterized protein (Fragment)	ISS	8108429	PubMed	PTHR11679:SF35	SYNTAXIN-BINDING PROTEIN 1
P00057	Wnt signaling pathway	P01435	SWI/SNF	PANTR|Ensembl=ENSPTRG00000008013|UniProtKB=H2RA84	Uncharacterized protein	ISS	11532957	PubMed	PTHR10799:SF935	HELICASE SRCAP
P06664	Gonadotropin-releasing hormone receptor pathway	P06817	BMP2/4/15	MOUSE|MGI=MGI=1316745|UniProtKB=Q9Z0L4	Bone morphogenetic protein 15	RCA	9759503	PubMed	PTHR11848:SF22	BONE MORPHOGENETIC PROTEIN 15
P02738	De novo purine biosynthesis	P02907	dADP kinase	HUMAN|HGNC=7853|UniProtKB=P56597	Nucleoside diphosphate kinase homolog 5	ISS			PTHR11349:SF64	NUCLEOSIDE DIPHOSPHATE KINASE HOMOLOG 5
P04393	Ras Pathway	P04570	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P05918	p38 MAPK pathway	P06031	p38alpha	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	RAT|RGD=2351|UniProtKB=P12392	Neuronal acetylcholine receptor subunit beta-4	IC	22213672	PubMed	PTHR18945:SF385	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-4
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	HUMAN|HGNC=6693|UniProtKB=Q9NZR2	Low-density lipoprotein receptor-related protein 1B	IDA	11907044	PubMed	PTHR44025:SF7	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B
P02756	N-acetylglucosamine metabolism	P03036	N-acetylglucosamine-6-phosphate deacetylase	FUSNN|EnsemblGenome=FN1133|UniProtKB=Q8REH0	N-acetylglucosamine-6-phosphate deacetylase	ISS			PTHR11113:SF1	N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00203	Erk	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04398	p53 pathway feedback loops 2	P04651	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00009	Axon guidance mediated by netrin	P00365	MAX-1	CAEBR|Gene=CBG09441|UniProtKB=A8X936	Protein CBR-MAX-1	ISS	22058614	PubMed	PTHR22903:SF8	MAX-1A
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	PANTR|Ensembl=ENSPTRG00000018684|UniProtKB=C7G3M7	Glutamate receptor, metabotropic 1	ISS	7476890	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00005	Angiogenesis	P00227	PLA2	MONDO|Ensembl=ENSMODG00000011791|UniProtKB=F7CBU9	Phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IC	8132661	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000011231|UniProtKB=F6WXV4	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00036	Interleukin signaling pathway	P00983	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00715	AGS3	MACMU|Ensembl=ENSMMUG00000003081|UniProtKB=F7DSI4	Uncharacterized protein	ISS	11121039	PubMed	PTHR10098:SF36	G-PROTEIN-SIGNALING MODULATOR 1
P00034	Integrin signalling pathway	P00912	Arp2/3	PANTR|Ensembl=ENSPTRG00000019449|UniProtKB=H2QV01	Actin related protein 2/3 complex, subunit 1B, 41kDa	ISS	12473693	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00977	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00010	B cell activation	P00381	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IGI	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00644	p38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IGI	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=621025|UniProtKB=Q62711	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	15611108	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000016438|UniProtKB=F7GTQ2	Serine/threonine-protein kinase	ISS	12676944	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P00029	Huntington disease	P00790	beta-Tubulin	PANTR|Ensembl=ENSPTRG00000013680|UniProtKB=H2QKN9	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF112	TUBULIN BETA-1 CHAIN
P00005	Angiogenesis	P00215	Nck	PANTR|Ensembl=ENSPTRG00000012316|UniProtKB=H2QIH7	NCK adaptor protein 2	ISS	12874226	PubMed	PTHR44108:SF1	CYTOPLASMIC PROTEIN NCK2
P00057	Wnt signaling pathway	P01444	Wnt	BOVIN|Ensembl=ENSBTAG00000014291|UniProtKB=A6H6X8	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000025240|UniProtKB=F7A7I3	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P05731	GABA-B receptor II signaling	P05760	AC	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	RCA	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00052	TGF-beta signaling pathway	P01286	TGFbeta	RAT|RGD=2212|UniProtKB=P49002	Bone morphogenetic protein 3	TAS	9759503	PubMed	PTHR11848:SF144	BONE MORPHOGENETIC PROTEIN 3
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	NEUCR|EnsemblGenome=EFNCRG00000001793|UniProtKB=Q1K564	26S proteasome non-ATPase regulatory subunit 11	ISS	11280491	gi	PTHR10678:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	CAEEL|WormBase=WBGene00000112|UniProtKB=G5EC31	ALdehyde deHydrogenase	IC			PTHR42862:SF1	DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED
P00021	FGF signaling pathway	P00629	PP2A	DANRE|ZFIN=ZDB-GENE-030131-4433|UniProtKB=A8WGP3	Serine/threonine-protein phosphatase 4 catalytic subunit A	ISS			PTHR11668:SF22	SERINE/THREONINE-PROTEIN PHOSPHATASE 4 CATALYTIC SUBUNIT
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00018	EGF receptor signaling pathway	P00558	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DANRE|ZFIN=ZDB-GENE-030131-6503|UniProtKB=Q7ZUC5	Protein kinase C delta type	ISS	11880265	PubMed	PTHR24356:SF297	PROTEIN KINASE C DELTA TYPE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_127488|UniProtKB=C3XYC7	Putative uncharacterized protein	IDA	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00005	Angiogenesis	P00204	PLD	PANTR|Ensembl=ENSPTRG00000015626|UniProtKB=H2R1L6	Phospholipase D1, phosphatidylcholine-specific	ISS	9307024	PubMed	PTHR18896:SF57	PHOSPHOLIPASE D1
P00014	Cholesterol biosynthesis	P00496	Diphosphomevalonate decarboxylase	MOUSE|MGI=MGI=2179327|UniProtKB=Q99JF5	Diphosphomevalonate decarboxylase	ISS	4505289	gi	PTHR10977:SF3	DIPHOSPHOMEVALONATE DECARBOXYLASE
P04374	5HT2 type receptor mediated signaling pathway	P04417	5HT transporter	CANLF|Ensembl=ENSCAFG00000018990|UniProtKB=F1PXA1	Transporter	ISS	7681602	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P00010	B cell activation	P00385	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	NEUCR|EnsemblGenome=EFNCRG00000000159|UniProtKB=F5HH30	Guanine nucleotide-binding protein beta subunit	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CAEEL|WormBase=WBGene00015478|UniProtKB=Q11179	Putative serine/threonine-protein kinase C05D10.2	TAS			PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02736	Coenzyme A biosynthesis	P02885	Pantothenate kinase	MOUSE|MGI=MGI=2387466|UniProtKB=Q80YV4	Pantothenate kinase 4	ISS			PTHR12280:SF20	PANTOTHENATE KINASE 4
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00029	Huntington disease	P00776	c-Jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00010	B cell activation	P00383	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04393	Ras Pathway	P04542	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02772	Pyruvate metabolism	P03132	Pyruvate Kinase	ARATH|TAIR=AT3G25960|UniProtKB=Q9LU95	Pyruvate kinase	TAS	15228164	gi	PTHR11817:SF34	PYRUVATE KINASE
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000001187|UniProtKB=F6R8N9	Mitogen-activated protein kinase	ISS			PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00012	Cadherin signaling pathway	P00470	F-actin	PHYPA|Gene=PHYPADRAFT_107830|UniProtKB=A9TBG2	Actin 7	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Ensembl=ENSBTAG00000016187|UniProtKB=F1N213	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00057	Wnt signaling pathway	P01457	GBeta	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P02751	Lysine biosynthesis	P03006	Dihydrodipicolinate  reductase	GLOVI|EnsemblGenome=BAC89147|UniProtKB=Q7NLC0	4-hydroxy-tetrahydrodipicolinate reductase	ISS			PTHR20836:SF0	DIHYDRODIPICOLINATE REDUCTASE-LIKE PROTEIN CRR1, CHLOROPLASTIC
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01297	MEKK	PANTR|Ensembl=ENSPTRG00000016891|UniProtKB=H2R5K3	Uncharacterized protein	RCA	11730323	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	PANTR|Ensembl=ENSPTRG00000009209|UniProtKB=H2QD27	PSMC3 interacting protein	ISS			PTHR15938:SF0	HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04371	5-Hydroxytryptamine biosynthesis	P04400	Aromatic L-amino acid decarboxylase	MOUSE|MGI=MGI=94876|UniProtKB=O88533	Aromatic-L-amino-acid decarboxylase	IEA	7567987	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00010	B cell activation	P00371	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00059	p53 pathway	P01486	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	CAEEL|WormBase=WBGene00018569|UniProtKB=Q7JP68	cAMP-dependent protein kinase, catalytic subunit-like	IDA	1319556	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00010	B cell activation	P00399	Ig-alpha	PANTR|Ensembl=ENSPTRG00000011038|UniProtKB=H2QGF1	Uncharacterized protein	ISS	2023945	PubMed	PTHR14334:SF1	B-CELL ANTIGEN RECEPTOR COMPLEX-ASSOCIATED PROTEIN ALPHA CHAIN
P04395	Vasopressin synthesis	P04593	Glycopeptide	RAT|RGD=3238|UniProtKB=P01179	Oxytocin-neurophysin 1	IC	3768139	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P02785	Valine biosynthesis	P03218	Dihydroxy isovalerate dehydratase	NEUCR|EnsemblGenome=EFNCRG00000005870|UniProtKB=Q1K658	Dihydroxy-acid dehydratase	ISS			PTHR21000:SF5	DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL
P00005	Angiogenesis	P00211	GSK3beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	P00551	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00053	T cell activation	P01306	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P05913	Enkephalin release	P05978	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P06664	Gonadotropin-releasing hormone receptor pathway	P06807	gnai	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	RCA	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P02769	Purine metabolism	P03117	5'-AMP Deaminase	DICDI|dictyBase=DDB_G0292266|UniProtKB=Q54DD0	AMP deaminase	NAS	7638159	gi	PTHR11359:SF0	AMP DEAMINASE, ISOFORM K
P00048	PI3 kinase pathway	P01192	p110	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00187	beta catenin	MONDO|Ensembl=ENSMODG00000011192|UniProtKB=F6SRK5	Uncharacterized protein	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00562	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00047	PDGF signaling pathway	P01150	PKC	RAT|RGD=620146|UniProtKB=O08874	Serine/threonine-protein kinase N2	ISS	11554554	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00021	FGF signaling pathway	P00640	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P06664	Gonadotropin-releasing hormone receptor pathway	P06779	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	RCA	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00644	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00036	Interleukin signaling pathway	P00990	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00547	PP2A	SCHMA|EnsemblGenome=Smp_165490|UniProtKB=C1LZY9	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	8170357	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00047	PDGF signaling pathway	P01155	Jak	HUMAN|HGNC=6190|UniProtKB=P23458	Tyrosine-protein kinase JAK1	ISS	11929133	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00021	FGF signaling pathway	P00630	RKIP	ORYSJ|EnsemblGenome=OS12G0152000|UniProtKB=Q2QXL9	CENTRORADIALIS, putative, expressed	ISS			PTHR11362:SF13	PROTEIN TERMINAL FLOWER 1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00053	T cell activation	P01307	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CAEEL|WormBase=WBGene00003774|UniProtKB=G5EGQ9	NMDA class glutamate Receptor	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00019	Endothelin signaling pathway	P00591	PLCbeta	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95808|UniProtKB=P23818	Glutamate receptor 1	ISS	12871085	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DANRE|ZFIN=ZDB-GENE-030131-172|UniProtKB=Q6IQR3	Actin, alpha, cardiac muscle 1a	ISS	10974003	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00053	T cell activation	P01336	Jnk	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	MYCTU|EnsemblGenome=Rv0733|UniProtKB=P9WKF5	Adenylate kinase	ISS			PTHR23359:SF22	GTP:AMP PHOSPHOTRANSFERASE, MITOCHONDRIAL
P00047	PDGF signaling pathway	P01174	Rho	CAEEL|WormBase=WBGene00006406|UniProtKB=Q19370	Slit-Robo GAP homolog	ISS			PTHR14166:SF17	SLIT-ROBO GAP HOMOLOG
P00046	Oxidative stress response	P01135	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00054	Toll receptor signaling pathway	P01369	MKK1	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04398	p53 pathway feedback loops 2	P04651	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00757	beta-arrestin	HUMAN|HGNC=10521|UniProtKB=P10523	S-arrestin	IDA	10206946	PubMed	PTHR11792:SF15	S-ARRESTIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P02738	De novo purine biosynthesis	P02891	GDP kinase	PANTR|Ensembl=ENSPTRG00000014882|UniProtKB=H2QMI8	Nucleoside diphosphate kinase	ISS			PTHR11349:SF70	NUCLEOSIDE DIPHOSPHATE KINASE 6
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00011	Blood coagulation	P00431	tPA	BOVIN|Ensembl=ENSBTAG00000001244|UniProtKB=Q28198	Tissue-type plasminogen activator	ISS	2499868	gi	PTHR44617:SF1	TISSUE-TYPE PLASMINOGEN ACTIVATOR
P00056	VEGF signaling pathway	P01402	MEK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS			PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9062|UniProtKB=Q9BRC7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	15611108	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00642	MEK1-2	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04393	Ras Pathway	P04559	Rac	ARATH|TAIR=AT1G20090|UniProtKB=Q38919	Rac-like GTP-binding protein ARAC4	ISS	12932731	PubMed	PTHR24072:SF194	RAC-LIKE GTP-BINDING PROTEIN ARAC4-RELATED
P06664	Gonadotropin-releasing hormone receptor pathway	P06800	PACAP	MOUSE|MGI=MGI=105094|UniProtKB=O70176	Pituitary adenylate cyclase-activating polypeptide	RCA			PTHR11213:SF1	PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00981	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04393	Ras Pathway	P04556	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00561	STAT	HUMAN|HGNC=11364|UniProtKB=P40763	Signal transducer and activator of transcription 3	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00047	PDGF signaling pathway	P01153	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00010	B cell activation	P00398	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00029	Huntington disease	P00770	N-CoR	HUMAN|HGNC=7673|UniProtKB=Q9Y618	Nuclear receptor corepressor 2	IPI	11112321	PubMed	PTHR13992:SF21	NUCLEAR RECEPTOR COREPRESSOR 2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CANLF|Ensembl=ENSCAFG00000016020|UniProtKB=O18840	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00005	Angiogenesis	P00219	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MACMU|Gene=C5AR1|UniProtKB=P79188	C5a anaphylatoxin chemotactic receptor 1 (Fragment)	ISS	10352266	PubMed	PTHR24225:SF29	C5A ANAPHYLATOXIN CHEMOTACTIC RECEPTOR 1
P00057	Wnt signaling pathway	P01444	Wnt	DANRE|ZFIN=ZDB-GENE-980526-332|UniProtKB=P51028	Protein Wnt-8a	IDA	11266476	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00034	Integrin signalling pathway	P00908	p130CAS	HUMAN|HGNC=971|UniProtKB=P56945	Breast cancer anti-estrogen resistance protein 1	IPI	8649368	PubMed	PTHR10654:SF15	BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00053	T cell activation	P01300	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	HUMAN|HGNC=1442|UniProtKB=P62158	Calmodulin	IDA	9753452	PubMed	PTHR23050:SF311	CALMODULIN
P00057	Wnt signaling pathway	P01443	Phospholipase C	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	ISS	11554549	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P05915	Opioid proenkephalin pathway	P05994	G-protein	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	HUMAN|HGNC=145|UniProtKB=P63267	Actin, gamma-enteric smooth muscle	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00010	B cell activation	P00402	Jnk	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00019	Endothelin signaling pathway	P00568	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	10747026	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	BOVIN|Ensembl=ENSBTAG00000003602|UniProtKB=Q3SZ41	Recombining binding protein suppressor of hairless	ISS	9043084	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IDA	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00047	PDGF signaling pathway	P01161	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ARATH|TAIR=AT2G42100|UniProtKB=Q8RYC2	Putative actin-5	ISS	14684598	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P02746	Heme biosynthesis	P02980	Coproporphyrinogen Oxidase (oxygen dependent)	PANTR|Ensembl=ENSPTRG00000015151|UniProtKB=H2QMZ9	Coproporphyrinogen oxidase	ISS			PTHR10755:SF0	OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05730	Endogenous cannabinoid signaling	P05751	Galpha	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IPI	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00049	Parkinson disease	P01208	Hsp70	ASHGO|EnsemblGenome=AGOS_ABL174C|UniProtKB=Q75E44	Heat shock protein SSB	ISS	12150907	PubMed	PTHR19375:SF256	HSP70 PROTEIN-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MOUSE|MGI=MGI=102891|UniProtKB=P51829	Adenylate cyclase type 7	IDA	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00005	Angiogenesis	P00251	cPLA2	CANLF|Ensembl=ENSCAFG00000013778|UniProtKB=F6UQ33	Phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	PANTR|Ensembl=ENSPTRG00000023062|UniProtKB=H2R2U1	Catenin (Cadherin-associated protein), beta 1, 88kDa	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00036	Interleukin signaling pathway	P00968	Ikk	HUMAN|HGNC=1974|UniProtKB=O15111	Inhibitor of nuclear factor kappa-B kinase subunit alpha	IDA	12813046	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MOUSE|MGI=MGI=87887|UniProtKB=Q8R4G9	Neuronal acetylcholine receptor subunit alpha-3	IC	18005395	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00049	Parkinson disease	P01212	p38 MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05917	Opioid proopiomelanocortin pathway	P06011	AC	RAT|RGD=619966|UniProtKB=F1LQT1	Adenylate cyclase 7	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00749	RGS9	HUMAN|HGNC=10004|UniProtKB=O75916	Regulator of G-protein signaling 9	IDA	8756726	PubMed	PTHR10845:SF170	REGULATOR OF G-PROTEIN SIGNALING 9
P00018	EGF receptor signaling pathway	P00541	Spry	MACMU|Ensembl=ENSMMUG00000001662|UniProtKB=F7G6M6	Uncharacterized protein	ISS			PTHR12365:SF9	PROTEIN SPROUTY HOMOLOG 3
P00019	Endothelin signaling pathway	P00585	ECE1-3	PANTR|Ensembl=ENSPTRG00000000298|UniProtKB=H2R1S0	Endothelin converting enzyme 1	ISS	96192242	PubMed	PTHR11733:SF130	ENDOTHELIN-CONVERTING ENZYME 1
P00005	Angiogenesis	P00223	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MACMU|Ensembl=ENSMMUG00000014762|UniProtKB=F7G0R4	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF344	MYOSIN-7
P00052	TGF-beta signaling pathway	P01284	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	ANOGA|Gene=AgaP_AGAP009115|UniProtKB=Q7PW25	Phosphoinositide phospholipase C (Fragment)	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00006	Apoptosis signaling pathway	P00321	HSP70	CANLF|Ensembl=ENSCAFG00000016031|UniProtKB=E2QX84	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF216	HEAT SHOCK-RELATED 70 KDA PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2744|UniProtKB=P31422	Metabotropic glutamate receptor 3	IDA	12351712	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00021	FGF signaling pathway	P00634	MEKK1-5	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00034	Integrin signalling pathway	P00938	Cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01306	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00047	PDGF signaling pathway	P01162	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00059	p53 pathway	P01486	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	DROME|FlyBase=FBgn0001123|UniProtKB=P20354	G protein alpha s subunit	IC	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000022548|UniProtKB=F6Y9J9	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00049	Parkinson disease	P01235	Fyn kinase	RAT|RGD=2641|UniProtKB=Q62844	Tyrosine-protein kinase Fyn	IDA	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00005	Angiogenesis	P00249	PAK	MONDO|Ensembl=ENSMODG00000018459|UniProtKB=F7CU42	Uncharacterized protein	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00059	p53 pathway	P04616	PDK1/2	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05918	p38 MAPK pathway	P05919	MAPKAP-K3	RAT|RGD=1304980|UniProtKB=Q66H84	MAP kinase-activated protein kinase 3	ISS	11157753	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00643	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00034	Integrin signalling pathway	P00951	Jnk	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04557	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01440	Cadherin	BOVIN|Gene=CDHR1|UniProtKB=Q8WN91	Cadherin-related family member 1	IDA	8120095	PubMed	PTHR44506:SF1	CADHERIN-RELATED FAMILY MEMBER 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=621025|UniProtKB=Q62711	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	7822322	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00018	EGF receptor signaling pathway	P00539	14-3-3	RAT|RGD=62000|UniProtKB=P62260	14-3-3 protein epsilon	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	HUMAN|HGNC=4588|UniProtKB=O15399	Glutamate receptor ionotropic, NMDA 2D	ISS	14698601	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	BOVIN|Ensembl=ENSBTAG00000018445|UniProtKB=E1BK87	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P02738	De novo purine biosynthesis	P02903	Phosphoribosylglycinamide  formyltransferase	ARATH|TAIR=AT4G17360|UniProtKB=F4JP46	Formyltetrahydrofolate deformylase 2, mitochondrial	ISS			PTHR42706:SF1	FORMYLTETRAHYDROFOLATE DEFORMYLASE 1, MITOCHONDRIAL-RELATED
P00021	FGF signaling pathway	P00632	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00568	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	15572354	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00053	T cell activation	P01332	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IDA	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00546	GAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	8262392	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04393	Ras Pathway	P04570	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00975	RasGAP	HUMAN|HGNC=9871|UniProtKB=P20936	Ras GTPase-activating protein 1	IC	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	PANTR|Ensembl=ENSPTRG00000017389|UniProtKB=H2R334	Uncharacterized protein	ISS	15118808	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05912	Dopamine receptor mediated signaling pathway	P05949	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8051109	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00005	Angiogenesis	P00244	MAPKAPK2/3	HUMAN|HGNC=6887|UniProtKB=P49137	MAP kinase-activated protein kinase 2	ISS	10779545	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00091	Aph-1	MACMU|Ensembl=ENSMMUG00000017856|UniProtKB=F7DK04	Uncharacterized protein	ISS	12110170	PubMed	PTHR12889:SF1	GAMMA-SECRETASE SUBUNIT APH-1B
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CANLF|Ensembl=ENSCAFG00000012181|UniProtKB=F2Z4N7	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00018	EGF receptor signaling pathway	P00551	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MOUSE|MGI=MGI=1923959|UniProtKB=Q9CVB6	Actin-related protein 2/3 complex subunit 2	ISS	17943202	gi	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	IC	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	CANLF|Ensembl=ENSCAFG00000003995|UniProtKB=E2RC09	Tyrosine-protein kinase	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	11790551	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	TAS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00035	Interferon-gamma signaling pathway	P00953	Jak1	CHICK|Ensembl=ENSGALG00000011031|UniProtKB=F1NMJ9	Tyrosine-protein kinase	TAS	11929133	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	RCA	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04665	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00045	Notch signaling pathway	G01541	E(spl)-C genes	CANLF|Gene_ORFName=BC8|UniProtKB=Q9TSZ2	Hairy/enhancer-of-split related with YRPW motif protein 1	IC			PTHR10985:SF78	HAIRY/ENHANCER-OF-SPLIT RELATED WITH YRPW MOTIF PROTEIN 1
P00053	T cell activation	P01298	NFkappaB	CANLF|Ensembl=ENSCAFG00000010155|UniProtKB=E2RLL2	Uncharacterized protein	ISS	12574369	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00057	Wnt signaling pathway	P01465	Ggamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00003	Alzheimer disease-amyloid secretase pathway	P00091	Aph-1	CANLF|Ensembl=ENSCAFG00000011777|UniProtKB=E2R5H5	Anterior pharynx defective 1 homolog A	ISS	12110170	PubMed	PTHR12889:SF3	GAMMA-SECRETASE SUBUNIT APH-1A
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05731	GABA-B receptor II signaling	P05752	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	10218114	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00046	Oxidative stress response	P01134	cPLA2	MONDO|Ensembl=ENSMODG00000011791|UniProtKB=F7CBU9	Phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	ORNAN|Ensembl=ENSOANG00000000999|UniProtKB=F6WN02	Actin-related protein 2/3 complex subunit 5	ISS	12932731	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P02722	Acetate utilization	P02802	Phosphate acetyltransferase	FUSNN|EnsemblGenome=FN1172|UniProtKB=Q8RED6	Phosphate acetyltransferase	ISS			PTHR43356:SF3	PHOSPHATE ACETYLTRANSFERASE
P00047	PDGF signaling pathway	P01175	Shc	PANTR|Ensembl=ENSPTRG00000021091|UniProtKB=H2QXF3	Uncharacterized protein	ISS	9507002	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P04393	Ras Pathway	P04544	Grb2	DANRE|ZFIN=ZDB-GENE-040426-1975|UniProtKB=Q6PC73	Growth factor receptor-bound protein 2	ISS	http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd	Website	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00036	Interleukin signaling pathway	P00990	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	PANTR|Ensembl=ENSPTRG00000001751|UniProtKB=H2Q0Q5	Glutamine synthetase	ISS			PTHR20852:SF45	GLUTAMINE SYNTHETASE
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01457	GBeta	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	XENTR|Xenbase=XB-GENE-961282|UniProtKB=Q6DF43	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00019	Endothelin signaling pathway	P00591	PLCbeta	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	IGI	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00056	VEGF signaling pathway	P01408	Akt/PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00021	FGF signaling pathway	P00623	FGF	CHICK|Ensembl=ENSGALG00000011835|UniProtKB=P48800	Fibroblast growth factor 2	ISS			PTHR11486:SF83	FIBROBLAST GROWTH FACTOR 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01095	beta	PANTR|Ensembl=ENSPTRG00000008689|UniProtKB=H2QC41	Uncharacterized protein	ISS	22213672	PubMed	PTHR18945:SF477	ACETYLCHOLINE RECEPTOR SUBUNIT BETA
P00053	T cell activation	P01311	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00001	Adrenaline and noradrenaline biosynthesis	P00066	DOPA decarb.	CAEEL|WormBase=WBGene00000239|UniProtKB=O45137	Biogenic Amine Synthesis related	ISS	90339966	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00036	Interleukin signaling pathway	P00976	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	ARATH|TAIR=AT1G10210|UniProtKB=Q39021	Mitogen-activated protein kinase 1	TAS			PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=96274|UniProtKB=P28334	5-hydroxytryptamine receptor 1B	IDA	12181435	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P02769	Purine metabolism	P03116	Xanthine Oxidase	RAT|RGD=62043|UniProtKB=P22985	Xanthine dehydrogenase/oxidase	IDA	12969896	PubMed	PTHR11908:SF80	XANTHINE DEHYDROGENASE/OXIDASE
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	XENTR|Xenbase=XB-GENE-478121|UniProtKB=F6VPH2	Uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00054	Toll receptor signaling pathway	P01369	MKK1	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00047	PDGF signaling pathway	P01173	STAT	PANTR|Ensembl=ENSPTRG00000009200|UniProtKB=H2QD20	Signal transducer and activator of transcription	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=621005|UniProtKB=Q08849	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00016	Cytoskeletal regulation by Rho GTPase	P00507	Rho	MONDO|Ensembl=ENSMODG00000000981|UniProtKB=F7ES59	Uncharacterized protein	ISS	14871999	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	HUMAN|HGNC=9558|UniProtKB=Q9UNM6	26S proteasome non-ATPase regulatory subunit 13	ISS	99239941	PubMed	PTHR10539:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13
P00059	p53 pathway	G01566	TSP1	HUMAN|HGNC=11785|UniProtKB=P07996	Thrombospondin-1	IGI	7521539	PubMed	PTHR10199:SF78	THROMBOSPONDIN-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000008719|UniProtKB=F1MZX0	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02733	Carnitine metabolism	P02866	Carnitine dehydratase	SULSO|EnsemblGenome=SSO1343|UniProtKB=Q97YI0	L-carnitine dehydratase, putative (CaiB)	ISS			PTHR43949:SF6	SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE
P00005	Angiogenesis	P00210	eNOS	PANTR|Ensembl=ENSPTRG00000019868|UniProtKB=H2QVM2	Nitric oxide synthase	ISS	10435050	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01275	P38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000005727|UniProtKB=F6TQT6	Uncharacterized protein	ISS	10644715	PubMed	PTHR24356:SF246	SERINE/THREONINE-PROTEIN KINASE N1
P00054	Toll receptor signaling pathway	P01375	JNK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	ISS	7600581	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00203	Erk	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01444	Wnt	BOVIN|Ensembl=ENSBTAG00000022671|UniProtKB=F1MZV4	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04393	Ras Pathway	P04558	p38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00049	Parkinson disease	P01219	SAPK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04563	Ets	ORNAN|Ensembl=ENSOANG00000012104|UniProtKB=F7FH70	Uncharacterized protein	ISS	3060801	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IDA	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05916	Opioid prodynorphin pathway	P06002	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	PANTR|Ensembl=ENSPTRG00000002086|UniProtKB=H2Q1A9	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00760	Gtalpha	MONDO|Ensembl=ENSMODG00000012279|UniProtKB=F6YFY5	Uncharacterized protein	ISS	6264430	PubMed	PTHR10218:SF67	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-1
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	DROME|FlyBase=FBgn0001124|UniProtKB=A1ZAA5	Glutamate oxaloacetate transaminase 1, isoform B	ISS			PTHR11879:SF22	ASPARTATE AMINOTRANSFERASE
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	HUMAN|HGNC=4545|UniProtKB=P43250	G protein-coupled receptor kinase 6	RCA			PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P00053	T cell activation	P01300	ERK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00572	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00059	p53 pathway	P04633	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00475	Frizzled	MOUSE|MGI=MGI=108476|UniProtKB=Q61086	Frizzled-3	IDA	11212302	PubMed	PTHR11309:SF22	FRIZZLED-3
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IC	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00019	Endothelin signaling pathway	P00589	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	BOVIN|Gene=MYH2|UniProtKB=Q9BE41	Myosin-2	ISS	89264452	PubMed	PTHR13140:SF385	MYOSIN-2
P02746	Heme biosynthesis	P02972	Ferrochelatase	ANOGA|EnsemblGenome=AGAP003719|UniProtKB=Q7QG25	Ferrochelatase	ISS			PTHR11108:SF1	FERROCHELATASE, MITOCHONDRIAL
P04398	p53 pathway feedback loops 2	P04665	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01322	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	ARATH|TAIR=AT3G23580|UniProtKB=P50651	Ribonucleoside-diphosphate reductase small chain A	ISS			PTHR23409:SF24	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN A
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ORNAN|Ensembl=ENSOANG00000007405|UniProtKB=F7CIV4	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00575	furin	PANTR|Ensembl=ENSPTRG00000017091|UniProtKB=H2QR92	Proprotein convertase subtilisin/kexin type 1	ISS			PTHR42884:SF14	NEUROENDOCRINE CONVERTASE 1
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	BOVIN|Ensembl=ENSBTAG00000019832|UniProtKB=G3MZV8	TGF-beta receptor type-2	ISS	9395284	PubMed	PTHR23255:SF55	TGF-BETA RECEPTOR TYPE-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	MACMU|Gene=CHRM1|UniProtKB=P56489	Muscarinic acetylcholine receptor M1	ISS	8100450	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000025373|UniProtKB=F6ZZG9	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	TRIAD|EnsemblGenome=TriadG49626|UniProtKB=B3RKR4	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00023	General transcription regulation	P00660	RNA Polymerase II	HUMAN|HGNC=9189|UniProtKB=P19387	DNA-directed RNA polymerase II subunit RPB3	ISS	2187864	PubMed	PTHR11800:SF2	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3
P00059	p53 pathway	P01486	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01151	PKB	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	MACMU|Ensembl=ENSMMUG00000008569|UniProtKB=F6UPU0	Uncharacterized protein	ISS	20355009	PubMed	PTHR15319:SF1	TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT C
P00047	PDGF signaling pathway	P01162	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	RAT|RGD=621705|UniProtKB=Q8VHN2	Glutamate receptor ionotropic, NMDA 3B	ISS	11319238	PubMed	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P04395	Vasopressin synthesis	P04590	Vasopressin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00049	Parkinson disease	P01221	Torsin A	RAT|RGD=1359111|UniProtKB=Q6AYR4	Torsin-2A	ISS	12421356	PubMed	PTHR10760:SF4	TORSIN-2A
P00059	p53 pathway	G04696	Siah	MACMU|Ensembl=ENSMMUG00000007400|UniProtKB=F6T3K3	E3 ubiquitin-protein ligase	ISS	11389839	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P02723	Adenine and hypoxanthine salvage pathway	P02810	Adenine phosphoribosyl transferase	ARATH|TAIR=AT5G11160|UniProtKB=Q9LFP0	Adenine phosphoribosyltransferase 5	ISS			PTHR11776:SF12	ADENINE PHOSPHORIBOSYLTRANSFERASE 2-RELATED
P00054	Toll receptor signaling pathway	P01376	Uev1A	CHICK|Ensembl=ENSGALG00000026906|UniProtKB=F1NKD9	Uncharacterized protein	ISS	20509589	PubMed	PTHR44178:SF1	FI14826P
P00036	Interleukin signaling pathway	P00996	STAT	PANTR|Ensembl=ENSPTRG00000009199|UniProtKB=H2QD19	Signal transducer and activator of transcription	ISS	95236292	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00059	p53 pathway	P01480	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00777	CBP	CAEEL|WormBase=WBGene00010545|UniProtKB=G5EBG3	CBP/p300 homolog	IDA	10769018	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00739	AGS3	MACMU|Ensembl=ENSMMUG00000003081|UniProtKB=F7DSI4	Uncharacterized protein	ISS	11121039	PubMed	PTHR10098:SF36	G-PROTEIN-SIGNALING MODULATOR 1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00010	B cell activation	P00379	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00049	Parkinson disease	P01211	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00005	Angiogenesis	P00236	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	ISS			PTHR10048:SF14	PI-3 KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	IDA	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00047	PDGF signaling pathway	P01159	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00019	Endothelin signaling pathway	P00583	cPLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00056	VEGF signaling pathway	P01414	PLC-gamma	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04393	Ras Pathway	P04569	Cdc42	DAPPU|EnsemblGenome=DAPPUDRAFT_306746|UniProtKB=E9GYE9	Putative uncharacterized protein	ISS	4757952	gi	PTHR24072:SF192	CDC42 HOMOLOG
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	TRYB2|Gene=Tb10.389.0490|UniProtKB=Q388U5	Protein kinase A catalytic subunit	ISS	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	RAT|RGD=2915|UniProtKB=P01322	Insulin-1	ISS			PTHR11454:SF24	INSULIN-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	BOVIN|Gene=RPS6KB1|UniProtKB=Q6TJY3	Ribosomal protein S6 kinase beta-1	ISS	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00059	p53 pathway	G04702	p53	PANTR|Ensembl=ENSPTRG00000008703|UniProtKB=H2QC53	Cellular tumor antigen p53	ISS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00014	Cholesterol biosynthesis	P00494	Squalene monooxygenas	HUMAN|HGNC=11279|UniProtKB=Q14534	Squalene monooxygenase	ISS			PTHR10835:SF0	SQUALENE MONOOXYGENASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DICDI|dictyBase=DDB_G0289811|UniProtKB=Q54GX7	Actin-10	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MOUSE|MGI=MGI=105303|UniProtKB=P35343	C-X-C chemokine receptor type 2	IDA	11801688	PubMed	PTHR10489:SF689	C-X-C CHEMOKINE RECEPTOR TYPE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00006	Apoptosis signaling pathway	P00273	p53	BOVIN|Ensembl=ENSBTAG00000001069|UniProtKB=P67939	Cellular tumor antigen p53	ISS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	ORNAN|Ensembl=ENSOANG00000011077|UniProtKB=F7FK62	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00021	FGF signaling pathway	P00644	p38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IGI	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	EMENI|EnsemblGenome=CADANIAG00006296|UniProtKB=Q5ASG1	Putative synaptobrevin homologue SNC1/2 (Eurofung)	ISS			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00010	B cell activation	P00402	Jnk	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00009	Axon guidance mediated by netrin	P00366	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00021	FGF signaling pathway	P00624	14-3-3	HUMAN|HGNC=12851|UniProtKB=P62258	14-3-3 protein epsilon	ISS	9450960	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00018	EGF receptor signaling pathway	P00564	Rac	DICDI|dictyBase=DDB_G0286555|UniProtKB=P34147	Rho-related protein racA	IGI	4757952	gi	PTHR24072:SF183	RHO-RELATED PROTEIN RACA
P00006	Apoptosis signaling pathway	P00299	Caspase 8	MACMU|Ensembl=ENSMMUG00000031296|UniProtKB=F7C587	Uncharacterized protein	ISS	11917123	PubMed	PTHR10454:SF162	CASPASE-8
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MOUSE|MGI=MGI=97009|UniProtKB=P33434	72 kDa type IV collagenase	TAS	12834808	PubMed	PTHR10201:SF29	72 KDA TYPE IV COLLAGENASE
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	MOUSE|MGI=MGI=2442695|UniProtKB=Q8BH52	Cyclic AMP-responsive element-binding protein 3-like protein 2	ISS	123810	OMIM	PTHR22952:SF96	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 2
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00005	Angiogenesis	P00249	PAK	BOVIN|Ensembl=ENSBTAG00000010191|UniProtKB=Q08E52	Serine/threonine-protein kinase PAK 1	ISS	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Ensembl=ENSPTRG00000016548|UniProtKB=H2QQC5	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00053	T cell activation	P01315	Calcineurin	MACMU|Ensembl=ENSMMUG00000014442|UniProtKB=F7BBG8	Serine/threonine-protein phosphatase	ISS	12091710	PubMed	PTHR11668:SF186	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT GAMMA ISOFORM
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00053	T cell activation	P01332	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	IDA	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00118	E-cadherin	MOUSE|MGI=MGI=88354|UniProtKB=P09803	Cadherin-1	IDA	8120095	PubMed	PTHR24027:SF319	CADHERIN-1
P00047	PDGF signaling pathway	P01159	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P02784	Tyrosine biosynthesis	P03213	Aromatic amino acid aminotransferase	DROME|FlyBase=FBgn0030558|UniProtKB=Q9VY42	CG1461, isoform A	ISS			PTHR11751:SF368	TYROSINE AMINOTRANSFERASE
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00189	Fzd	XENTR|Xenbase=XB-GENE-487022|UniProtKB=F6SH04	Uncharacterized protein (Fragment)	ISS	11212302	PubMed	PTHR11309:SF34	FRIZZLED-2
P00047	PDGF signaling pathway	P01173	STAT	MONDO|Ensembl=ENSMODG00000014836|UniProtKB=F7D2D3	Signal transducer and activator of transcription	ISS	96210005	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	CANAL|CGD=CAL0000176261|UniProtKB=P53704	Glutamine--fructose-6-phosphate aminotransferase [isomerizing]	ISS			PTHR10937:SF0	GH12731P-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00049	Parkinson disease	P01219	SAPK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01438	PP2A	TAKRU|Ensembl=ENSTRUG00000011169|UniProtKB=H2TU36	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	BOVIN|Ensembl=ENSBTAG00000008059|UniProtKB=P41984	Muscarinic acetylcholine receptor M3	TAS	11166329	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00018	EGF receptor signaling pathway	P00543	ERK1-2	ARATH|TAIR=AT1G10210|UniProtKB=Q39021	Mitogen-activated protein kinase 1	ISS			PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	MACMU|Ensembl=ENSMMUG00000017022|UniProtKB=F7HQZ9	Uncharacterized protein	ISS	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00056	VEGF signaling pathway	P01411	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-8225|UniProtKB=Q7SZZ5	Uncharacterized protein	ISS			PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00053	T cell activation	P01308	ZAP-70	MOUSE|MGI=MGI=99613|UniProtKB=P43404	Tyrosine-protein kinase ZAP-70	IPI	1423621	PubMed	PTHR24418:SF369	TYROSINE-PROTEIN KINASE ZAP-70
P00019	Endothelin signaling pathway	P00566	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	97442349	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	RAT|RGD=628750|UniProtKB=Q8CH33	Chemokine (C-C motif) receptor 9	ISS	11884450	PubMed	PTHR10489:SF664	C-C CHEMOKINE RECEPTOR TYPE 9
P00034	Integrin signalling pathway	P00924	Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	IPI	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00052	TGF-beta signaling pathway	P01286	TGFbeta	PANTR|Ensembl=ENSPTRG00000021908|UniProtKB=H2QYM3	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF22	BONE MORPHOGENETIC PROTEIN 15
P06959	CCKR signaling map	P07089	CK1delta/epsilon	HUMAN|HGNC=2452|UniProtKB=P48730	Casein kinase I isoform delta	RCA	17962809	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000017341|UniProtKB=Q5DRD5	Protocadherin beta-14	ISS	8120095	PubMed	PTHR24028:SF81	PROTOCADHERIN BETA-14
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=102705|UniProtKB=P63213	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00047	PDGF signaling pathway	P01162	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00029	Huntington disease	P00796	Kainate receptor	CHICK|Ensembl=ENSGALG00000006638|UniProtKB=R4GGL9	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01081	Ca2+ channel	MOUSE|MGI=MGI=88295|UniProtKB=O08532	Voltage-dependent calcium channel subunit alpha-2/delta-1	ISS	92228762	PubMed	PTHR10166:SF6	VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-1
P04398	p53 pathway feedback loops 2	P04665	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00023	General transcription regulation	P00660	RNA Polymerase II	BOVIN|Gene=POLR2E|UniProtKB=Q2T9T3	DNA-directed RNA polymerases I, II, and III subunit RPABC1	ISS			PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P00012	Cadherin signaling pathway	P00472	Tyrosine phosphatases	MACMU|Ensembl=ENSMMUG00000007878|UniProtKB=F7B6C1	Tyrosine-protein phosphatase non-receptor type	ISS			PTHR19134:SF239	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01461	FrzB	PANTR|Ensembl=ENSPTRG00000019092|UniProtKB=H2QUG0	Uncharacterized protein	ISS	9118218	PubMed	PTHR11309:SF7	SECRETED FRIZZLED-RELATED PROTEIN 4
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	HUMAN|HGNC=7850|UniProtKB=P22392	Nucleoside diphosphate kinase B	ISS			PTHR11349:SF57	NUCLEOSIDE DIPHOSPHATE KINASE B
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00048	PI3 kinase pathway	P01177	P110ACT	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CAEBR|Gene=CBG02162|UniProtKB=A8WS33	Protein CBG02162	ISS	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P05913	Enkephalin release	P05976	Enkephalin	XENTR|Xenbase=XB-GENE-942760|UniProtKB=F6Y5F6	Uncharacterized protein	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MOUSE|MGI=MGI=1354694|UniProtKB=Q9JL25	Regulator of G-protein signaling 1	IDA	8756726	PubMed	PTHR10845:SF34	REGULATOR OF G-PROTEIN SIGNALING 1
P00018	EGF receptor signaling pathway	P00545	JNK1-3	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IGI	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02738	De novo purine biosynthesis	P02889	dGDP kinase	STRCO|EnsemblGenome=CAB75393|UniProtKB=P50589	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P02772	Pyruvate metabolism	P03133	Pyruvate Dehydrogenase	SYNY3|Gene=BAA18592|UniProtKB=P74490	Pyruvate dehydrogenase E1 component subunit alpha	ISS	8590279	PubMed	PTHR11516:SF53	SUBFAMILY NOT NAMED
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MOUSE|MGI=MGI=1927899|UniProtKB=Q9JHI0	Matrix metalloproteinase-19	TAS	12834808	PubMed	PTHR10201:SF166	MATRIX METALLOPROTEINASE-19
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	RAT|RGD=2869|UniProtKB=P24062	Insulin-like growth factor 1 receptor	ISS	249616	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	RCA	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	RCA	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01167	Ets	PANTR|Ensembl=ENSPTRG00000003498|UniProtKB=A2T737	ETS homologous factor	ISS	15298723	PubMed	PTHR11849:SF171	ETS HOMOLOGOUS FACTOR
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	SCHPO|PomBase=SPAC23H4.06|UniProtKB=Q09179	Glutamine synthetase	ISS			PTHR20852:SF57	GLUTAMINE SYNTHETASE 2 CYTOPLASMIC
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	MACMU|Ensembl=ENSMMUG00000020819|UniProtKB=F7HSM1	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00205	GAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	227170	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00029	Huntington disease	P00805	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	LEIMA|EnsemblGenome=LmjF.30.3500|UniProtKB=Q4Q6T6	S-adenosylmethionine synthase	ISS			PTHR11964:SF1	S-ADENOSYLMETHIONINE SYNTHASE
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	DROME|FlyBase=FBgn0011743|UniProtKB=P45891	Actin-like protein 53D	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PANTR|Ensembl=ENSPTRG00000006890|UniProtKB=H2Q943	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00053	T cell activation	P01300	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00639	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	95096035	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00010	B cell activation	P00371	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	20384797	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00587	Raf-1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	HUMAN|HGNC=11588|UniProtKB=P20226	TATA-box-binding protein	ISS	11988536	PubMed	PTHR10126:SF20	TATA-BOX-BINDING PROTEIN
P00034	Integrin signalling pathway	P00947	Laminin	RAT|RGD=1308889|UniProtKB=F1M614	Protein Lama2	ISS	2538453	PubMed	PTHR10574:SF291	LAMININ SUBUNIT ALPHA-2
P00029	Huntington disease	P00787	MAPKK4	HUMAN|HGNC=6844|UniProtKB=P45985	Dual specificity mitogen-activated protein kinase kinase 4	NAS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	HUMAN|HGNC=1964|UniProtKB=P30926	Neuronal acetylcholine receptor subunit beta-4	IC	11602335	PubMed	PTHR18945:SF385	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-4
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	BOVIN|Ensembl=ENSBTAG00000025337|UniProtKB=F1MZX6	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF504	MYOSIN-13
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IGI	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	22246731	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MOUSE|MGI=MGI=95814|UniProtKB=Q60934	Glutamate receptor ionotropic, kainate 1	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04393	Ras Pathway	P04546	GSK3	HUMAN|HGNC=4616|UniProtKB=P49840	Glycogen synthase kinase-3 alpha	IDA	2164470	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00048	PI3 kinase pathway	P01199	Galpha	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00029	Huntington disease	P00810	GAPDH	ARATH|TAIR=AT3G04120|UniProtKB=P25858	Glyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic	ISS			PTHR10836:SF60	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE GAPC1, CYTOSOLIC
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P06664	Gonadotropin-releasing hormone receptor pathway	P06749	CREB	MOUSE|MGI=MGI=88494|UniProtKB=Q01147	Cyclic AMP-responsive element-binding protein 1	RCA	11752053	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00633	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	9860142	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=1915409|UniProtKB=Q8R1Q0	Syntaxin-19	IC	11067767	PubMed	PTHR19957:SF29	SYNTAXIN-19
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	HUMAN|HGNC=6694|UniProtKB=P98164	Low-density lipoprotein receptor-related protein 2	IDA	11907044	PubMed	PTHR44025:SF5	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01173	STAT	MONDO|Ensembl=ENSMODG00000014836|UniProtKB=F7D2D3	Signal transducer and activator of transcription	ISS	22320921	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00006	Apoptosis signaling pathway	P00321	HSP70	BOVIN|Ensembl=ENSBTAG00000025441|UniProtKB=Q27975	Heat shock 70 kDa protein 1A	ISS	12150907	PubMed	PTHR19375:SF223	HEAT SHOCK 70 KDA PROTEIN 1A-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00020	FAS signaling pathway	P00616	Nuclear Lamin	XENTR|Xenbase=XB-GENE-920613|UniProtKB=A4IHY3	Lmnb3 protein	ISS	11165516	PubMed	PTHR23239:SF119	LAMIN L3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00018	EGF receptor signaling pathway	P00546	GAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	IGI	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00047	PDGF signaling pathway	P01151	PKB	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	PANTR|Gene=CHRM2|UniProtKB=Q9N2A7	Muscarinic acetylcholine receptor M2 (Fragment)	ISS	11166329	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00591	PLCbeta	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IGI	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	SCHPO|PomBase=SPAC17G8.14c|UniProtKB=P36582	Protein kinase C-like 1	TAS	93259141	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00018	EGF receptor signaling pathway	P00547	PP2A	RAT|RGD=3381|UniProtKB=P62716	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00037	Ionotropic glutamate receptor pathway	P01026	KA	ORNAN|Ensembl=ENSOANG00000010302|UniProtKB=F6TDQ6	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	MONDO|Ensembl=ENSMODG00000016960|UniProtKB=F6V5G0	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	YEAST|SGD=S000001328|UniProtKB=P21672	Ribonucleoside-diphosphate reductase large chain 2	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	DICDI|dictyBase=DDB_G0279413|UniProtKB=P05987	cAMP-dependent protein kinase regulatory subunit	ISS	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00054	Toll receptor signaling pathway	P01346	TLR	MACMU|Ensembl=ENSMMUG00000003373|UniProtKB=B3Y674	Toll-like receptor	ISS			PTHR24365:SF23	TOLL-LIKE RECEPTOR 10
P00018	EGF receptor signaling pathway	P00548	RKIP	CAEEL|WormBase=WBGene00018218|UniProtKB=O16264	Phosphatidylethanolamine-binding protein homolog F40A3.3	ISS			PTHR11362:SF28	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P00009	Axon guidance mediated by netrin	P00364	cdc42	DAPPU|EnsemblGenome=DAPPUDRAFT_306746|UniProtKB=E9GYE9	Putative uncharacterized protein	ISS	4757952	gi	PTHR24072:SF192	CDC42 HOMOLOG
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	PANTR|Ensembl=ENSPTRG00000006872|UniProtKB=H2RCB4	Uncharacterized protein	ISS	15226293	PubMed	PTHR13715:SF16	RYANODINE RECEPTOR 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	HUMAN|HGNC=4616|UniProtKB=P49840	Glycogen synthase kinase-3 alpha	IDA	183955	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P06959	CCKR signaling map	G06978	CHGA	HUMAN|HGNC=1929|UniProtKB=P10645	Chromogranin-A	RCA	9852054	PubMed	PTHR10583:SF1	CHROMOGRANIN-A
P00057	Wnt signaling pathway	P01458	Protein Kinase C	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00181	SHP2	CANLF|Ensembl=ENSCAFG00000008894|UniProtKB=F1Q3J6	Tyrosine-protein phosphatase non-receptor type	ISS	7681589	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	BOVIN|Ensembl=ENSBTAG00000012516|UniProtKB=F1MUT8	Uncharacterized protein	ISS	94365697	PubMed	PTHR11958:SF22	EXCITATORY AMINO ACID TRANSPORTER 5
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	HUMAN|HGNC=18855|UniProtKB=Q68CJ9	Cyclic AMP-responsive element-binding protein 3-like protein 3	ISS	123810	OMIM	PTHR22952:SF98	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 3
P00048	PI3 kinase pathway	P01192	p110	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00471	Cadherin	CHICK|Gene=CDH11|UniProtKB=O93319	Cadherin-11	IDA	8120095	PubMed	PTHR24027:SF85	CADHERIN-11
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	DROME|FlyBase=FBgn0003888|UniProtKB=P08841	Tubulin beta-3 chain	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00036	Interleukin signaling pathway	P00983	Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	IC	12068308	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P05731	GABA-B receptor II signaling	P05755	Gbeta	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00189	Fzd	XENTR|Xenbase=XB-GENE-484322|UniProtKB=F6RPG1	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF22	FRIZZLED-3
P00053	T cell activation	P01306	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P05731	GABA-B receptor II signaling	P05755	Gbeta	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	RCA	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8971|UniProtKB=O00443	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00591	PLCbeta	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00056	VEGF signaling pathway	P01408	Akt/PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12539654	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00981	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00046	Oxidative stress response	P01121	MKK3/6	BOVIN|Ensembl=ENSBTAG00000010576|UniProtKB=A4IFH7	MAP2K3 protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04393	Ras Pathway	P04573	Elk-1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	IDA	11050086	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00034	Integrin signalling pathway	P00922	Collagen	PANTR|Ensembl=ENSPTRG00000013074|UniProtKB=H2QJP2	Uncharacterized protein	ISS	10778855	PubMed	PTHR44105:SF2	COLLAGEN ALPHA-3 VI  CHAIN
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	9516481	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	BRAFL|Gene=BRAFLDRAFT_215305|UniProtKB=C3YPV2	Putative uncharacterized protein (Fragment)	ISS	9230079	PubMed	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00005	Angiogenesis	P00254	GTPase	BOVIN|Ensembl=ENSBTAG00000004279|UniProtKB=P61585	Transforming protein RhoA	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00048	PI3 kinase pathway	P01179	PKB	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	TAS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00794	Hippi	BOVIN|Ensembl=ENSBTAG00000005787|UniProtKB=Q5EA95	Intraflagellar transport protein 57 homolog	ISS	11788820	PubMed	PTHR16011:SF0	INTRAFLAGELLAR TRANSPORT PROTEIN 57 HOMOLOG
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	BACSU|EnsemblGenome=BSU20040|UniProtKB=O30601	SPBc2 prophage-derived ribonucleoside-diphosphate reductase subunit beta	ISS			PTHR23409:SF32	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT BETA
P04398	p53 pathway feedback loops 2	G04715	CYCLIN G	MACMU|Ensembl=ENSMMUG00000019550|UniProtKB=F7CKQ1	Uncharacterized protein	ISS	11983168	PubMed	PTHR10177:SF59	CYCLIN-G1
P06959	CCKR signaling map	P07194	MAP2K1	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	RCA	7611406	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05913	Enkephalin release	P05974	G-Protein (i)	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00052	TGF-beta signaling pathway	P01287	BAMBI	DANRE|ZFIN=ZDB-GENE-010416-1|UniProtKB=Q9DFZ0	BMP and activin membrane-bound inhibitor homolog	TAS	10519551	PubMed	PTHR15505:SF1	BMP AND ACTIVIN MEMBRANE-BOUND INHIBITOR HOMOLOG
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000016187|UniProtKB=F1N213	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00021	FGF signaling pathway	P00623	FGF	MOUSE|MGI=MGI=95516|UniProtKB=P15655	Fibroblast growth factor 2	IGI	12917328	PubMed	PTHR11486:SF83	FIBROBLAST GROWTH FACTOR 2
P00005	Angiogenesis	P00248	Ang-1	MACMU|Ensembl=ENSMMUG00000017745|UniProtKB=F7F3F4	Angiopoietin-1	ISS	8980223	PubMed	PTHR19143:SF156	ANGIOPOIETIN-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	TAS	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00012	Cadherin signaling pathway	P00470	F-actin	MACMU|Ensembl=ENSMMUG00000012054|UniProtKB=F6TII3	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00047	PDGF signaling pathway	P01143	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00543	ERK1-2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01423	p38MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	ANOGA|EnsemblGenome=AGAP008908|UniProtKB=Q7PWN2	AGAP008908-PA	ISS	12963527	gi	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P00057	Wnt signaling pathway	P01428	Frizzled	MACMU|Ensembl=ENSMMUG00000022114|UniProtKB=F7H7V5	Uncharacterized protein	ISS	12549854	PubMed	PTHR11309:SF81	FRIZZLED-1
P00024	Glycolysis	P00671	Phosphoglycerate kinase	METAC|EnsemblGenome=MA_3592|UniProtKB=Q8TK32	Phosphoglycerate kinase 2	ISS	21929760	PubMed	PTHR11406:SF0	PHOSPHOGLYCERATE KINASE
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	ANOGA|EnsemblGenome=AGAP003424|UniProtKB=Q7QDI9	AGAP003424-PA	TAS	1768802	PubMed	PTHR18914:SF9	CATENIN ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CAEEL|WormBase=WBGene00004036|UniProtKB=G5EFI8	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	IC	91056091	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	PANTR|Ensembl=ENSPTRG00000009279|UniProtKB=H2QD74	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF34	FRIZZLED-2
P04398	p53 pathway feedback loops 2	P04668	p53	DANRE|ZFIN=ZDB-GENE-030819-1|UniProtKB=E9QG65	Uncharacterized protein	TAS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00046	Oxidative stress response	P01135	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01159	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00018	EGF receptor signaling pathway	P00557	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	PANTR|Ensembl=ENSPTRG00000023608|UniProtKB=H2QZZ2	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	HUMAN|HGNC=2861|UniProtKB=P00374	Dihydrofolate reductase	ISS			PTHR22778:SF39	DIHYDROFOLATE REDUCTASE
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00872	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	RCA			PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00047	PDGF signaling pathway	P01173	STAT	PANTR|Ensembl=ENSPTRG00000009200|UniProtKB=H2QD20	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P02723	Adenine and hypoxanthine salvage pathway	P02807	Deoxyadenosine deaminase	MYCTU|EnsemblGenome=Rv3313c|UniProtKB=P63907	Adenosine deaminase	ISS			PTHR11409:SF43	ADENOSINE DEAMINASE
P00029	Huntington disease	P00788	Calpain	MACMU|Ensembl=ENSMMUG00000001534|UniProtKB=F7G923	Uncharacterized protein	ISS	11675509	PubMed	PTHR10183:SF329	CALPAIN-3
P05918	p38 MAPK pathway	P06020	p38delta	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	RCA	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00047	PDGF signaling pathway	P01173	STAT	PANTR|Ensembl=ENSPTRG00000009200|UniProtKB=H2QD20	Signal transducer and activator of transcription	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00022	General transcription by RNA polymerase I	P00649	TAF-IC	CHICK|Ensembl=ENSGALG00000003498|UniProtKB=Q5ZMS1	Transcription initiation factor TFIID subunit 8	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	TAS	12885769	PubMed	PTHR10202:SF13	PRESENILIN-2
P00053	T cell activation	P01312	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CHICK|Ensembl=ENSGALG00000011086|UniProtKB=P68139	Actin, alpha skeletal muscle	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P02746	Heme biosynthesis	P02980	Coproporphyrinogen Oxidase (oxygen dependent)	CHLRE|EnsemblGenome=CHLREDRAFT_53583|UniProtKB=Q9S7V1	Coproporphyrinogen III oxidase	ISS			PTHR10755:SF0	OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL
P00053	T cell activation	P01312	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00558	SOS	CHICK|Ensembl=ENSGALG00000013224|UniProtKB=F1NMA4	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00021	FGF signaling pathway	P00629	PP2A	BRAFL|Gene=BRAFLDRAFT_123893|UniProtKB=C3XQF4	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00950	Paxillin	DROME|FlyBase=FBgn0041789|UniProtKB=Q2PDT4	Paxillin, isoform F	IPI	7579684	PubMed	PTHR24216:SF8	PAXILLIN, ISOFORM F
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000014828|UniProtKB=F1N1E0	Uncharacterized protein	ISS	14624853	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P02759	Pyridoxal-5-phosphate biosynthesis	P03062	1-Deoxyxylulose-5-phosphate synthase	FUSNN|EnsemblGenome=FN1464|UniProtKB=Q8R606	1-deoxy-D-xylulose-5-phosphate synthase	ISS			PTHR43322:SF1	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00127	APP	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	RCA	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00004	Alzheimer disease-presenilin pathway	P00145	CD44	MACMU|Ensembl=ENSMMUG00000004327|UniProtKB=F6ZDZ8	Uncharacterized protein	ISS	14871815	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	CANLF|Ensembl=ENSCAFG00000019633|UniProtKB=F1PDC7	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00049	Parkinson disease	P01238	14-3-3	RAT|RGD=1359510|UniProtKB=Q5EBB0	Protein LOC298795	ISS	10407019	PubMed	PTHR18860:SF14	14-3-3 PROTEIN SIGMA
P00034	Integrin signalling pathway	P00949	Shc	MOUSE|MGI=MGI=98296|UniProtKB=P98083	SHC-transforming protein 1	IPI	8264585	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01174	Rho	BOVIN|Gene=DLC1|UniProtKB=A7E300	Rho GTPase-activating protein 7	ISS			PTHR12659:SF2	RHO GTPASE-ACTIVATING PROTEIN 7
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000023940|UniProtKB=F6RFW8	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04393	Ras Pathway	P04551	RalGDS	PANTR|Ensembl=ENSPTRG00000021509|UniProtKB=H2QY37	Uncharacterized protein	ISS	7809086	PubMed	PTHR23113:SF35	RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR
P00048	PI3 kinase pathway	P01188	Gbetagamma	ANOGA|EnsemblGenome=AGAP005913|UniProtKB=Q7Q6D2	AGAP005913-PA	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	RAT|RGD=620859|UniProtKB=O70239	Axin-1	IEP	12356903	PubMed	PTHR10845:SF11	AXIN-1
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	ORNAN|Ensembl=ENSOANG00000015652|UniProtKB=F7FY70	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	MONDO|Ensembl=ENSMODG00000005255|UniProtKB=F7G800	Uncharacterized protein	ISS	11259591	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	BOVIN|Ensembl=ENSBTAG00000006136|UniProtKB=E1BNY1	Uncharacterized protein	ISS			PTHR11644:SF2	CYTIDINE DEAMINASE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	89107990	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DICPU|Gene=DICPUDRAFT_90232|UniProtKB=F1A175	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00053	T cell activation	P01320	PLC-gamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00034	Integrin signalling pathway	P00923	Arf1	XENTR|Xenbase=XB-GENE-950251|UniProtKB=Q6NT85	ADP-ribosylation factor 1	ISS	11752622	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	IPI	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000012005|UniProtKB=F7H091	Metabotropic glutamate receptor 2 isoform a	ISS	12351712	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	RAT|RGD=628837|UniProtKB=P60711	Actin, cytoplasmic 1	IDA	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CANLF|Ensembl=ENSCAFG00000015708|UniProtKB=F2Z4N0	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00036	Interleukin signaling pathway	P00983	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02725	Allantoin degradation	P02822	Allantoinase	ECOLI|EcoGene=EG13619|UniProtKB=P77671	Allantoinase	ISS			PTHR43668:SF2	ALLANTOINASE
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	RCA	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01440	Cadherin	CHICK|Ensembl=ENSGALG00000012942|UniProtKB=F1NPQ8	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF106	CADHERIN-18
P04393	Ras Pathway	P04560	AP1	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	12972619	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04395	Vasopressin synthesis	P04589	Signal Peptidase	CAEEL|WormBase=WBGene00021844|UniProtKB=Q9N3D0	Signal peptidase complex catalytic subunit SEC11	IC	2674115	PubMed	PTHR10806:SF6	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11
P00005	Angiogenesis	P00182	p38MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	TAKRU|Ensembl=ENSTRUG00000013411|UniProtKB=H2UB84	Uncharacterized protein	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00025	Hedgehog signaling pathway	P00682	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	CRYNJ|EnsemblGenome=CND03830|UniProtKB=Q5KI86	Uncharacterized protein	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00034	Integrin signalling pathway	P00920	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05730	Endogenous cannabinoid signaling	P05746	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00049	Parkinson disease	P01230	Src kinase	PANTR|Ensembl=ENSPTRG00000018511|UniProtKB=H2QTK7	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04553	PAK	ORNAN|Ensembl=ENSOANG00000002406|UniProtKB=F7BAS2	Uncharacterized protein	ISS	11259591	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00049	Parkinson disease	P01211	ERK	ORYSJ|Gene=Os01g0665200|UniProtKB=Q5SN53	Mitogen-activated protein kinase 8	IDA			PTHR24055:SF219	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00052	TGF-beta signaling pathway	P01284	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00049	Parkinson disease	P01211	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00024	Glycolysis	P00679	Aldolase	RAT|RGD=1359133|UniProtKB=Q6AY07	Fructose-bisphosphate aldolase	ISS	3391172	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	ORYSJ|EnsemblGenome=OS03G0780600|UniProtKB=P37832	Tubulin beta-7 chain	ISS	12932731	PubMed	PTHR11588:SF146	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	G01563	MDM-2	MACMU|Ensembl=ENSMMUG00000014193|UniProtKB=F7AKR9	Uncharacterized protein	ISS	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P02787	Vitamin B6 metabolism	P03244	Pyridoxal kinase	SCHPO|PomBase=SPCC18.10|UniProtKB=O74860	Putative pyridoxal kinase C18.10	ISS	11859360	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P00060	Ubiquitin proteasome pathway	P01491	E2	RAT|RGD=1564746|UniProtKB=B5DFI8	Ubiquitin-conjugating enzyme E2 S	ISS			PTHR44066:SF1	UBIQUITIN-CONJUGATING ENZYME E2 S
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	MOUSE|MGI=MGI=1321161|UniProtKB=P62715	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P02787	Vitamin B6 metabolism	P03242	Threonine synthase	AQUAE|EnsemblGenome=aq_425|UniProtKB=O66740	Threonine synthase	ISS	9537320	PubMed	PTHR10314:SF5	THREONINE SYNTHASE 1, CHLOROPLASTIC
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CAEEL|WormBase=WBGene00004038|UniProtKB=Q22070	Phosphoinositide phospholipase C	TAS			PTHR10336:SF91	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01076	CAT	BOVIN|Ensembl=ENSBTAG00000016814|UniProtKB=F1MLQ5	Uncharacterized protein	ISS	97225904	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	TAS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00020	FAS signaling pathway	P00615	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05918	p38 MAPK pathway	P06031	p38alpha	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00048	PI3 kinase pathway	P01179	PKB	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	TAS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	XENTR|Xenbase=XB-GENE-6469705|UniProtKB=Q6P8G3	Actin, alpha sarcomeric/skeletal	ISS	11889126	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P05913	Enkephalin release	P05974	G-Protein (i)	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	IC	1482697	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00018	EGF receptor signaling pathway	P00541	Spry	DANRE|ZFIN=ZDB-GENE-010803-2|UniProtKB=F1QZW4	Uncharacterized protein	IGI	21384945	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P00005	Angiogenesis	P00219	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01023	CaMKII	RAT|RGD=621802|UniProtKB=P11730	Calcium/calmodulin-dependent protein kinase type II subunit gamma	ISS	12888804	PubMed	PTHR43940:SF7	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT GAMMA
P00029	Huntington disease	P00780	Microtubule	MACMU|Ensembl=ENSMMUG00000023684|UniProtKB=P69895	Tubulin beta chain	ISS	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00046	Oxidative stress response	P01135	p38	CAEEL|WormBase=WBGene00004055|UniProtKB=Q17446	Mitogen-activated protein kinase pmk-1	TAS	11703092	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	176910	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00049	Parkinson disease	P01211	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	12657601	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00036	Interleukin signaling pathway	P00983	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01154	Ras	DANRE|ZFIN=ZDB-GENE-990415-166|UniProtKB=P79737	GTPase NRas	ISS	9116869	PubMed	PTHR24070:SF189	GTPASE NRAS
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00047	PDGF signaling pathway	P01152	RasGAP	HUMAN|HGNC=23181|UniProtKB=O43374	Ras GTPase-activating protein 4	ISS	6635197	gi	PTHR10194:SF4	RAS GTPASE-ACTIVATING PROTEIN 4-RELATED
P00018	EGF receptor signaling pathway	P00559	MEK1-2	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00551	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02722	Acetate utilization	P02802	Phosphate acetyltransferase	THEMA|EnsemblGenome=TM_1130|UniProtKB=Q9X0L4	Phosphate acetyltransferase	ISS			PTHR43356:SF2	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00590	IP3 R	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	IGI	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00645	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=1951|UniProtKB=P08172	Muscarinic acetylcholine receptor M2	IDA	12181435	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	MOUSE|MGI=MGI=95810|UniProtKB=Q9Z2W9	Glutamate receptor 3	IC	10331083	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00018	EGF receptor signaling pathway	P00552	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P05731	GABA-B receptor II signaling	P05752	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00019	Endothelin signaling pathway	P00591	PLCbeta	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04397	p53 pathway by glucose deprivation	P04640	p53	DANRE|ZFIN=ZDB-GENE-990415-270|UniProtKB=P79734	Cellular tumor antigen p53	TAS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00007	Axon guidance mediated by semaphorins	P00341	Rho	PANTR|Ensembl=ENSPTRG00000014922|UniProtKB=H2QML4	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00018	EGF receptor signaling pathway	P00539	14-3-3	ENTHI|EnsemblGenome=EHI_025360|UniProtKB=C4M323	14-3-3 protein 1	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00924	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IPI	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CAEEL|WormBase=WBGene00004036|UniProtKB=G5EFI8	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00029	Huntington disease	P00778	NMDA receptor	MACMU|Ensembl=ENSMMUG00000016675|UniProtKB=F6VTB5	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CHICK|Ensembl=ENSGALG00000028749|UniProtKB=Q5ZMQ2	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00223	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P01486	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00005	Angiogenesis	P00238	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00034	Integrin signalling pathway	P00912	Arp2/3	MOUSE|MGI=MGI=1915021|UniProtKB=Q9CPW4	Actin-related protein 2/3 complex subunit 5	ISS	12932731	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00056	VEGF signaling pathway	P01409	cPLA2	PANTR|Ensembl=ENSPTRG00000001787|UniProtKB=H2Q0T0	Phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	YEAST|SGD=S000005738|UniProtKB=P18851	Guanine nucleotide-binding protein subunit beta	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04393	Ras Pathway	P04559	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	10891487	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00005	Angiogenesis	P00202	Sck	HUMAN|HGNC=29869|UniProtKB=P98077	SHC-transforming protein 2	IDA	10749680	PubMed	PTHR10337:SF5	SHC-TRANSFORMING PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	CANLF|Ensembl=ENSCAFG00000009203|UniProtKB=F1PVZ1	Muscarinic acetylcholine receptor	ISS	91373358	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	TAS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BOVIN|Ensembl=ENSBTAG00000014614|UniProtKB=P62739	Actin, aortic smooth muscle	ISS	3487386	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MACMU|Ensembl=ENSMMUG00000002368|UniProtKB=F7BZY1	Uncharacterized protein	ISS	93330551	PubMed	PTHR10177:SF67	G1/S-SPECIFIC CYCLIN-D1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	8262392	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00047	PDGF signaling pathway	P01148	Grb2	DROME|FlyBase=FBgn0004638|UniProtKB=Q08012	Protein enhancer of sevenless 2B	ISS	51702266	gi	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	HUMAN|HGNC=9299|UniProtKB=P67775	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00045	Notch signaling pathway	P01103	Next	HUMAN|HGNC=7881|UniProtKB=P46531	Neurogenic locus notch homolog protein 1	IGI	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IDA	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=2685045|UniProtKB=E9QAN8	Protein Pik3c2b	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00539	14-3-3	PANTR|Ensembl=ENSPTRG00000008521|UniProtKB=G2HI54	14-3-3 protein epsilon	ISS	9450960	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00036	Interleukin signaling pathway	P00990	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P06217	Toll pathway-drosophila	P06342	CACT	DROME|FlyBase=FBgn0000250|UniProtKB=Q03017	NF-kappa-B inhibitor cactus	IDA	8808632	PubMed	PTHR24139:SF26	NUCLEAR FACTOR OF KAPPA LIGHT POLYPEPTIDE GENE ENHANCER IN B-CELLS INHIBITOR, ALPHA B
P00010	B cell activation	P00371	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	TAS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00005	Angiogenesis	P00236	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00637	MKK4,7	MONDO|Ensembl=ENSMODG00000008266|UniProtKB=F6Z879	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00053	T cell activation	P01312	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P02754	Methylcitrate cycle	P03028	Aconitase	ARATH|TAIR=AT4G35830|UniProtKB=Q42560	Aconitate hydratase 1	ISS			PTHR11670:SF52	ACONITATE HYDRATASE 1
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IGI	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P05731	GABA-B receptor II signaling	P05758	K channel	BOVIN|Ensembl=ENSBTAG00000006159|UniProtKB=E1BNE9	G protein-activated inward rectifier potassium channel 1	ISS	12374786	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00010	B cell activation	P00385	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04541	p90RSK	HUMAN|HGNC=10430|UniProtKB=Q15418	Ribosomal protein S6 kinase alpha-1	ISS	7688567	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P04393	Ras Pathway	P04546	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	IDA	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	BOVIN|Ensembl=ENSBTAG00000006495|UniProtKB=P11017	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00049	Parkinson disease	P01236	Casein kinase II	ORYSJ|EnsemblGenome=OS07G0114400|UniProtKB=Q8H386	Casein kinase II alpha subunit	ISS	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	88234494	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00552	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	91232861	PubMed	PTHR24070:SF385	GTPASE HRAS
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CAEBR|Gene=CBG19269|UniProtKB=A8XV82	Protein CBR-HUM-2 (Fragment)	ISS			PTHR13140:SF725	DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02775	Salvage pyrimidine ribonucleotides	P03155	Cytosine deaminase	CAEEL|WormBase=WBGene00012968|UniProtKB=Q9XXD0	Uncharacterized protein	ISS			PTHR44192:SF2	SUBFAMILY NOT NAMED
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	MOUSE|MGI=MGI=1347062|UniProtKB=Q9Z125	Cyclic AMP-responsive element-binding protein 3-like protein 1	ISS	608972	OMIM	PTHR22952:SF24	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 1
P00046	Oxidative stress response	P01135	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	TAS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000008190|UniProtKB=H2QB92	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF89	CADHERIN-5
P00012	Cadherin signaling pathway	P00462	Casein kinase II	XENTR|Xenbase=XB-GENE-487924|UniProtKB=F6WVD0	Casein kinase II subunit beta (Fragment)	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00045	Notch signaling pathway	P01113	Pen-2	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	12885769	PubMed	PTHR10202:SF13	PRESENILIN-2
P00046	Oxidative stress response	P01135	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00019	Endothelin signaling pathway	P00570	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00011	Blood coagulation	P00447	FVIIa	PANTR|Gene=F7|UniProtKB=Q2F9P2	Coagulation factor VII	ISS	4503645	gi	PTHR44064:SF1	COAGULATION FACTOR VII
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00047	PDGF signaling pathway	P01168	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	BOVIN|Ensembl=ENSBTAG00000008059|UniProtKB=P41984	Muscarinic acetylcholine receptor M3	TAS	12915051	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00021	FGF signaling pathway	P00648	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00046	Oxidative stress response	P01132	c-jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00021	FGF signaling pathway	P00638	PLCgamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IGI	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	MOUSE|MGI=MGI=1096584|UniProtKB=Q8VDM4	26S proteasome non-ATPase regulatory subunit 2	ISS			PTHR10943:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2
P00047	PDGF signaling pathway	P01143	ERK	BOVIN|Ensembl=ENSBTAG00000001014|UniProtKB=A5PKJ4	Mitogen-activated protein kinase 7	ISS	12912994	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00047	PDGF signaling pathway	P01150	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00046	Oxidative stress response	P01125	Stat1	DANRE|ZFIN=ZDB-GENE-980526-499|UniProtKB=Q6P943	Signal transducer and activator of transcription	TAS	10417824	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00006	Apoptosis signaling pathway	P00318	PKCs	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00006	Apoptosis signaling pathway	P00313	IKK	BOVIN|Ensembl=ENSBTAG00000007591|UniProtKB=Q95KV1	Inhibitor of nuclear factor kappa-B kinase subunit alpha	ISS	14499113	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000005792|UniProtKB=F6VTR8	Uncharacterized protein	ISS	12507995	PubMed	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00029	Huntington disease	P00775	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12874273	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00057	Wnt signaling pathway	P01443	Phospholipase C	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00057	Wnt signaling pathway	P01428	Frizzled	MOUSE|MGI=MGI=1196625|UniProtKB=O70421	Frizzled-1	IDA	8717036	PubMed	PTHR11309:SF81	FRIZZLED-1
P00021	FGF signaling pathway	P00640	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	HUMAN|HGNC=5182|UniProtKB=P35367	Histamine H1 receptor	IDA			PTHR43914:SF2	HISTAMINE H1 RECEPTOR
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IDA	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	MOUSE|MGI=MGI=1339975|UniProtKB=O88643	Serine/threonine-protein kinase PAK 1	ISS	14580336	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00053	T cell activation	P01319	PAK	RAT|RGD=61953|UniProtKB=Q64303	Serine/threonine-protein kinase PAK 2	IDA	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00005	Angiogenesis	P00243	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	3449797	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00057	Wnt signaling pathway	P01457	GBeta	ANOGA|EnsemblGenome=AGAP005913|UniProtKB=Q7Q6D2	AGAP005913-PA	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	176910	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00807	Actin	XENTR|Xenbase=XB-GENE-480347|UniProtKB=Q6P640	Actin, alpha cardiac muscle 1	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04578	Rho	MOUSE|MGI=MGI=106028|UniProtKB=Q62159	Rho-related GTP-binding protein RhoC	IDA	12090470	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	MOUSE|MGI=MGI=1917655|UniProtKB=Q9D6P8	Calmodulin-like protein 3	ISS	9753452	PubMed	PTHR23050:SF197	CALMODULIN-LIKE PROTEIN 3
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=97441|UniProtKB=P42866	Mu-type opioid receptor	IDA	11259487	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IGI	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00631	Grb2	CAEBR|Gene=CBG16856|UniProtKB=A8XPY6	Protein CBR-SEM-5	ISS	8307166	PubMed	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00036	Interleukin signaling pathway	P00970	Interleukin	HUMAN|HGNC=16404|UniProtKB=Q96PD4	Interleukin-17F	IC			PTHR45214:SF1	INTERLEUKIN-17F
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000011231|UniProtKB=F6WXV4	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00036	Interleukin signaling pathway	P00976	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04393	Ras Pathway	P04578	Rho	RAT|RGD=621309|UniProtKB=P62747	Rho-related GTP-binding protein RhoB	ISS	13679859	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00036	Interleukin signaling pathway	P00973	PKB	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04393	Ras Pathway	P04572	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00056	VEGF signaling pathway	P01425	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	10644715	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00029	Huntington disease	P00782	alpha-Adaptin	HUMAN|HGNC=562|UniProtKB=O94973	AP-2 complex subunit alpha-2	IDA	11532990	PubMed	PTHR22780:SF4	AP-2 COMPLEX SUBUNIT ALPHA-2
P00029	Huntington disease	P00807	Actin	CANAL|CGD=CAL0064759|UniProtKB=Q5AKX0	Uncharacterized protein	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00001	Adrenaline and noradrenaline biosynthesis	P00066	DOPA decarb.	HUMAN|HGNC=2719|UniProtKB=P20711	Aromatic-L-amino-acid decarboxylase	ISS	90339966	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	20331588	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	HUMAN|HGNC=4383|UniProtKB=P30679	Guanine nucleotide-binding protein subunit alpha-15	IDA	8838318	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MOUSE|MGI=MGI=109248|UniProtKB=Q920H4	Muscarinic acetylcholine receptor M5	IDA	11166329	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	RCA	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00029	Huntington disease	P00805	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ORYSJ|EnsemblGenome=OS12G0163700|UniProtKB=Q0IPW3	Os12g0163700 protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	HUMAN|HGNC=5292|UniProtKB=P30939	5-hydroxytryptamine receptor 1F	ISS	12441358	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	HUMAN|HGNC=903|UniProtKB=O15169	Axin-1	IEP	12356903	PubMed	PTHR10845:SF11	AXIN-1
P00047	PDGF signaling pathway	P01143	ERK	BOVIN|Ensembl=ENSBTAG00000001014|UniProtKB=A5PKJ4	Mitogen-activated protein kinase 7	ISS	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	DROME|FlyBase=FBgn0003132|UniProtKB=Q05547	Serine/threonine-protein phosphatase alpha-3 isoform	ISS	8392016	PubMed	PTHR11668:SF402	SERINE/THREONINE-PROTEIN PHOSPHATASE
P00029	Huntington disease	P00790	beta-Tubulin	STRPU|EnsemblGenome=SPU_003894|UniProtKB=W4XKG7	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF155	TUBULIN BETA-2 CHAIN
P00021	FGF signaling pathway	P00628	JNK1-3	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04392	P53 pathway feedback loops 1	P04537	p73DeltaN	MOUSE|MGI=MGI=1330810|UniProtKB=O88898	Tumor protein 63	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	12488551	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000005791|UniProtKB=F6UB42	Uncharacterized protein	ISS			PTHR15593:SF1	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 6
P00034	Integrin signalling pathway	P00911	B-Raf	MOUSE|MGI=MGI=88190|UniProtKB=P28028	Serine/threonine-protein kinase B-raf	IDA	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00052	TGF-beta signaling pathway	P01288	FKBP12	DANRE|ZFIN=ZDB-GENE-030131-7275|UniProtKB=Q6PBJ8	Peptidyl-prolyl cis-trans isomerase	ISS			PTHR10516:SF341	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00019	Endothelin signaling pathway	P00572	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	IDA	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00048	PI3 kinase pathway	P01179	PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P02765	Phenylalanine biosynthesis	P03100	Chorismate mutase	GLOVI|Gene=BAC90646|UniProtKB=Q7NH32	Chorismate mutase AroH	ISS			PTHR21164:SF0	SUBFAMILY NOT NAMED
P00010	B cell activation	P00391	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	PANTR|Ensembl=ENSPTRG00000016293|UniProtKB=H2QPW8	Serine/threonine-protein kinase receptor	ISS	9395284	PubMed	PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P00048	PI3 kinase pathway	P01192	p110	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04556	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000008429|UniProtKB=F1ML31	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF4	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00047	PDGF signaling pathway	P01143	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	RCA	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02775	Salvage pyrimidine ribonucleotides	P03151	Uracil phosphoribosyl  transferase	MYCTU|EnsemblGenome=Rv3309c|UniProtKB=P9WFF3	Uracil phosphoribosyltransferase	ISS			PTHR10285:SF46	URACIL PHOSPHORIBOSYLTRANSFERASE, CHLOROPLASTIC
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04398	p53 pathway feedback loops 2	G04715	CYCLIN G	CANLF|Ensembl=ENSCAFG00000017207|UniProtKB=E2RSX2	Uncharacterized protein	ISS	7957050	PubMed	PTHR10177:SF59	CYCLIN-G1
P00034	Integrin signalling pathway	P00944	Actin	MACMU|Ensembl=ENSMMUG00000012054|UniProtKB=F6TII3	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	MACMU|Ensembl=ENSMMUG00000016529|UniProtKB=Q8HYP5	C-C motif chemokine 21	ISS	11801633	PubMed	PTHR12015:SF72	C-C MOTIF CHEMOKINE 21
P05916	Opioid prodynorphin pathway	P06002	G-protein	SCHPO|PomBase=SPBC32H8.07|UniProtKB=Q10282	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00005	Angiogenesis	P00212	EphR	RAT|RGD=1564232|UniProtKB=A0A0G2JY48	Protein Ephb2	ISS	9990854	PubMed	PTHR24416:SF123	EPHRIN TYPE-B RECEPTOR 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	CAEBR|Gene=CBG09510|UniProtKB=A8X8Y1	Protein CBG09510	ISS	11437445	PubMed	PTHR11909:SF19	ASATOR, ISOFORM D
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MOUSE|MGI=MGI=1347465|UniProtKB=O88621	Forkhead box protein H1	IGI	8878477	PubMed	PTHR11829:SF191	FORKHEAD BOX PROTEIN H1
P00053	T cell activation	P01315	Calcineurin	MACMU|Ensembl=ENSMMUG00000004599|UniProtKB=F6Q932	Serine/threonine-protein phosphatase	ISS	12015605	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	BRAFL|Gene=BRAFLDRAFT_113587|UniProtKB=C3ZBE3	Putative uncharacterized protein	ISS	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00059	p53 pathway	P01485	p53	HUMAN|HGNC=15979|UniProtKB=Q9H3D4	Tumor protein 63	TAS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000006158|UniProtKB=H2R9F4	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF272	CADHERIN-24
P00036	Interleukin signaling pathway	P00997	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	8264585	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00021	FGF signaling pathway	P00629	PP2A	MONDO|Ensembl=ENSMODG00000019001|UniProtKB=F7CP86	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	TAS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00057	Wnt signaling pathway	P01456	beta-arrestin	HUMAN|HGNC=712|UniProtKB=P32121	Beta-arrestin-2	IDA	12464600	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=87935|UniProtKB=P30545	Alpha-2B adrenergic receptor	IDA	6323229	PubMed	PTHR24248:SF26	ALPHA-2B ADRENERGIC RECEPTOR
P00018	EGF receptor signaling pathway	P00552	Ras	BOVIN|Ensembl=ENSBTAG00000009778|UniProtKB=E1BMX0	Uncharacterized protein	ISS	3023884	PubMed	PTHR24070:SF186	GTPASE KRAS
P00015	Circadian clock system	G01504	bmal1	MACMU|Ensembl=ENSMMUG00000009690|UniProtKB=F6XNT8	Uncharacterized protein	ISS	11163178	PubMed	PTHR23042:SF52	ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 1
P06209	ALP23B signaling pathway	P06222	SARA	DROME|FlyBase=FBgn0026369|UniProtKB=Q7K9H6	FI05490p	IEA	http://flybase.org/reports/FBgn0026369.html	Website	PTHR22835:SF299	FI05490P
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00473	P120	PANTR|Ensembl=ENSPTRG00000003668|UniProtKB=H2R3Z0	Uncharacterized protein	ISS			PTHR10372:SF6	CATENIN DELTA-1
P00053	T cell activation	P01307	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00558	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	RCA	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	CANLF|Ensembl=ENSCAFG00000004381|UniProtKB=J9JH96	Uncharacterized protein	ISS	92317054	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	DROME|FlyBase=FBgn0039071|UniProtKB=Q9VCN3	Glutamate dehydrogenase	ISS			PTHR11606:SF7	GLUTAMATE DEHYDROGENASE
P00019	Endothelin signaling pathway	P00570	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	IC	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00029	Huntington disease	P00778	NMDA receptor	MOUSE|MGI=MGI=95823|UniProtKB=Q03391	Glutamate receptor ionotropic, NMDA 2D	IDA	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00005	Angiogenesis	P00237	FRP	RAT|RGD=61916|UniProtKB=Q08463	Frizzled-1	ISS	12549854	PubMed	PTHR11309:SF81	FRIZZLED-1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	ISS	91298951	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00887	IRS 1-4	PANTR|Ensembl=ENSPTRG00000012989|UniProtKB=H2QJJ4	Insulin receptor substrate 1	ISS	15110093	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=1860487|UniProtKB=A0A0A6YY83	Protein Pcdh7	ISS	8120095	PubMed	PTHR43912:SF8	PROTOCADHERIN-7
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	CHICK|Gene=ADCY9|UniProtKB=Q9DGG6	Adenylate cyclase type 9	IDA	21222856	PubMed	PTHR11920:SF319	ADENYLATE CYCLASE TYPE 9
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04393	Ras Pathway	P04570	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01275	P38	CAEEL|WormBase=WBGene00004055|UniProtKB=Q17446	Mitogen-activated protein kinase pmk-1	TAS	10514528	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	IDA	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00054	Toll receptor signaling pathway	P01352	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	DANRE|ZFIN=ZDB-GENE-051202-1|UniProtKB=E7F101	Uncharacterized protein	ISS	11554554	PubMed	PTHR44391:SF2	SUBFAMILY NOT NAMED
P00010	B cell activation	P00383	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04393	Ras Pathway	P04552	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IDA	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00049	Parkinson disease	P01230	Src kinase	HUMAN|HGNC=3955|UniProtKB=P42685	Tyrosine-protein kinase FRK	IDA	11078745	PubMed	PTHR24418:SF296	TYROSINE-PROTEIN KINASE FRK
P00019	Endothelin signaling pathway	P00572	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MACMU|Ensembl=ENSMMUG00000030358|UniProtKB=F7F3G9	Uncharacterized protein	ISS			PTHR18945:SF489	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-9
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00018	EGF receptor signaling pathway	P00539	14-3-3	ORYSJ|EnsemblGenome=OS08G0430500|UniProtKB=Q6ZKC0	14-3-3-like protein GF14-C	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P05915	Opioid proenkephalin pathway	P05991	Enkephalin	RAT|RGD=68946|UniProtKB=P04094	Proenkephalin-A	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04452	proopiomelanocortin	MOUSE|MGI=MGI=97742|UniProtKB=P01193	Pro-opiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00010	B cell activation	P00386	Calcineurin	PANTR|Ensembl=ENSPTRG00000002631|UniProtKB=H2Q237	Serine/threonine-protein phosphatase	ISS	12091710	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	MACMU|Ensembl=ENSMMUG00000000289|UniProtKB=F7A9T0	Uncharacterized protein	ISS	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00010	B cell activation	P00388	PLC gamma2	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	G01565	PERP	CANLF|Ensembl=ENSCAFG00000030892|UniProtKB=J9NZW5	Uncharacterized protein	ISS			PTHR14399:SF4	P53 APOPTOSIS EFFECTOR RELATED TO PMP-22
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000001962|UniProtKB=F6V2H6	Uncharacterized protein	ISS	8444355	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	MOUSE|MGI=MGI=1201678|UniProtKB=Q5SUF7	Protein Cacna1g	ISS	18021322	PubMed	PTHR10037:SF137	VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1G
P00059	p53 pathway	P01486	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02783	Tryptophan biosynthesis	P03206	Anthranilate synthase	FUSNN|EnsemblGenome=FN1731|UniProtKB=Q8RI82	Anthranilate synthase component II	RCA			PTHR43418:SF4	MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	MOUSE|MGI=MGI=88390|UniProtKB=P01216	Glycoprotein hormones alpha chain	ISS	15927770	PubMed	PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P00021	FGF signaling pathway	P00640	PI3K	DROME|FlyBase=FBgn0015278|UniProtKB=Q7K3H0	LD28067p	IGI	96278830	PubMed	PTHR10048:SF64	LD28067P
P00049	Parkinson disease	P01230	Src kinase	TAKRU|Ensembl=ENSTRUG00000003538|UniProtKB=H2S7D1	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF242	TYROSINE-PROTEIN KINASE FYNB
P06664	Gonadotropin-releasing hormone receptor pathway	P06831	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	RCA	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02770	Pyridoxal phosphate salvage pathway	P03123	Pyridoxine-5-phosphate oxidase	ECOLI|EcoGene=EG11487|UniProtKB=P0AFI7	Pyridoxine/pyridoxamine 5'-phosphate oxidase	ISS	11786019	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P05731	GABA-B receptor II signaling	P05754	Ggamma	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00990	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00020	FAS signaling pathway	P00600	PARP	MOUSE|MGI=MGI=1341112|UniProtKB=O88554	Poly [ADP-ribose] polymerase 2	TAS	12101391	PubMed	PTHR10459:SF60	POLY  ADP-RIBOSE  POLYMERASE 2
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00056	VEGF signaling pathway	P01408	Akt/PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00381	Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	IGI	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P02774	Salvage pyrimidine deoxyribonucleotides	P03147	Thymidine kinase	CAEEL|WormBase=WBGene00006568|UniProtKB=G5EEZ5	Thymidine kinase	ISS			PTHR11441:SF0	THYMIDINE KINASE, CYTOSOLIC
P04380	Cortocotropin releasing factor receptor signaling pathway	P04453	ACTH	MONDO|Ensembl=ENSMODG00000015853|UniProtKB=Q95J84	Proopiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CHICK|Gene=JUN|UniProtKB=P18870	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00056	VEGF signaling pathway	P01423	p38MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00011	Blood coagulation	P00419	FXIIIa	PANTR|Ensembl=ENSPTRG00000001806|UniProtKB=H2Q0U3	Uncharacterized protein	ISS	9961357	gi	PTHR19325:SF314	COAGULATION FACTOR XIII B CHAIN
P04393	Ras Pathway	P04567	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00163	Erb-B4 C-terminal fragment	ORNAN|Ensembl=ENSOANG00000007021|UniProtKB=F7GAV2	Receptor protein-tyrosine kinase	ISS	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00021	FGF signaling pathway	P00629	PP2A	RAT|RGD=3381|UniProtKB=P62716	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01202	p85	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01151	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=2157782|UniProtKB=Q8VHP6	Cadherin-related family member 1	IDA	8120095	PubMed	PTHR44506:SF1	CADHERIN-RELATED FAMILY MEMBER 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	TAKRU|Ensembl=ENSTRUG00000007501|UniProtKB=H2T1P2	Clathrin heavy chain	ISS	9388255	PubMed	PTHR10292:SF1	CLATHRIN HEAVY CHAIN
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	HUMAN|HGNC=1962|UniProtKB=P17787	Neuronal acetylcholine receptor subunit beta-2	IC	22213672	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	CHICK|Gene=FYN|UniProtKB=Q05876	Tyrosine-protein kinase Fyn	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	MOUSE|MGI=MGI=107928|UniProtKB=Q62148	Retinal dehydrogenase 2	IC	14724059	PubMed	PTHR11699:SF102	RETINAL DEHYDROGENASE 2
P00019	Endothelin signaling pathway	P00577	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	DROME|FlyBase=FBgn0004619|UniProtKB=Q03445	Glutamate receptor 1	ISS	8804111	PubMed	PTHR18966:SF270	GLUTAMATE RECEPTOR 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	XENTR|Xenbase=XB-GENE-493937|UniProtKB=Q5M8T9	Actin, alpha 2, smooth muscle, aorta	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IGI	12464394	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P02747	Histidine biosynthesis	P02985	Histidinol dehydrogenase	ECOLI|EcoGene=EG10447|UniProtKB=P06988	Histidinol dehydrogenase	ISS			PTHR21256:SF2	HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN
P00006	Apoptosis signaling pathway	P00268	GCK	DROME|FlyBase=FBgn0263395|UniProtKB=A1ZBH7	Happyhour, isoform A	ISS			PTHR24361:SF413	HAPPYHOUR, ISOFORM A
P00025	Hedgehog signaling pathway	P00682	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g169611|UniProtKB=A7SEB1	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01098	CHT1	CAEBR|Gene=CBG01811|UniProtKB=A8WQR8	Protein CBR-CHO-1	RCA			PTHR11819:SF12	HIGH-AFFINITY CHOLINE TRANSPORTER 1
P00057	Wnt signaling pathway	P01444	Wnt	DANRE|ZFIN=ZDB-GENE-081006-1|UniProtKB=F1Q9W3	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00624	14-3-3	ORYSJ|EnsemblGenome=OS08G0480800|UniProtKB=Q84J55	14-3-3-like protein GF14-A	ISS	10918058	PubMed	PTHR18860:SF26	14-3-3 FAMILY PROTEIN-RELATED
P00046	Oxidative stress response	P01135	p38	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	TAS	20451058	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	CHICK|Gene=CHRM4|UniProtKB=P17200	Muscarinic acetylcholine receptor M4	ISS	8100450	PubMed	PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	XENTR|Xenbase=XB-GENE-494200|UniProtKB=F7CS79	Uncharacterized protein	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00060	Ubiquitin proteasome pathway	P01491	E2	RAT|RGD=621096|UniProtKB=Q9EQX9	Ubiquitin-conjugating enzyme E2 N	ISS			PTHR43902:SF2	UBIQUITIN-CONJUGATING ENZYME E2 N
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00547	PP2A	PANTR|Ensembl=ENSPTRG00000006734|UniProtKB=H2Q8X8	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P00036	Interleukin signaling pathway	P00973	PKB	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P06587	Nicotine pharmacodynamics pathway	P06599	EPB41L1	RAT|RGD=71087|UniProtKB=Q9WTP0	Band 4.1-like protein 1	ISS	12181426	PubMed	PTHR23280:SF24	BAND 4.1-LIKE PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MACMU|Ensembl=ENSMMUG00000010987|UniProtKB=F7GCX9	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_206575|UniProtKB=E9FUX0	Guanine nucleotide binding protein, beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00057	Wnt signaling pathway	P01440	Cadherin	MONDO|Ensembl=ENSMODG00000006996|UniProtKB=F6XVG8	Uncharacterized protein (Fragment)	ISS	8120095	PubMed	PTHR24027:SF85	CADHERIN-11
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01211	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04398	p53 pathway feedback loops 2	P04658	PTEN	XENTR|Xenbase=XB-GENE-491433|UniProtKB=B1H2U0	Pten protein	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04393	Ras Pathway	P04569	Cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P02748	Isoleucine biosynthesis	P02997	Acetolactate synthase	PSEAE|EnsemblGenome=PA4696|UniProtKB=Q9HVA0	Acetolactate synthase	ISS			PTHR18968:SF116	ACETOLACTATE SYNTHASE ISOZYME 3 LARGE SUBUNIT
P00057	Wnt signaling pathway	P01451	Galpha	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	IDA	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05913	Enkephalin release	P05974	G-Protein (i)	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00583	cPLA2	RAT|RGD=67366|UniProtKB=P50393	Cytosolic phospholipase A2	IGI	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	MACMU|Ensembl=ENSMMUG00000023317|UniProtKB=F6Y514	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00056	VEGF signaling pathway	P01414	PLC-gamma	CAEBR|Gene=CBG18715|UniProtKB=A8XTZ1	Phosphoinositide phospholipase C	ISS			PTHR10336:SF91	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00021	FGF signaling pathway	P00642	MEK1-2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00019	Endothelin signaling pathway	P00566	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00184	Src	MACMU|Ensembl=ENSMMUG00000020131|UniProtKB=F7FWN4	Tyrosine-protein kinase	ISS	8054685	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00003	Alzheimer disease-amyloid secretase pathway	P00079	alpha7 nicotinic acetylcholine receptor	CHICK|Ensembl=ENSGALG00000015336|UniProtKB=Q03481	Alpha8 subunit of nicotinic acetylcholine receptor	IDA			PTHR18945:SF761	ALPHA8 SUBUNIT OF NICOTINIC ACETYLCHOLINE RECEPTOR
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00053	T cell activation	P01320	PLC-gamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00056	VEGF signaling pathway	P01411	Ras	DICDI|dictyBase=DDB_G0292998|UniProtKB=P32252	Ras-like protein rasB	ISS	7997267	PubMed	PTHR24070:SF206	RAS-LIKE PROTEIN RASB
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	BOVIN|Ensembl=ENSBTAG00000014583|UniProtKB=P62157	Calmodulin	ISS	3885394	PubMed	PTHR23050:SF335	CALMODULIN, STRIATED MUSCLE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	MACMU|Ensembl=ENSMMUG00000010184|UniProtKB=F6SR09	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	CAEBR|Gene=CBG14224|UniProtKB=A8XJJ7	Protein CBR-GLT-1	ISS	96032356	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P00010	B cell activation	P00383	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IDA	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00221	JNK1	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	PANTR|Ensembl=ENSPTRG00000009085|UniProtKB=H2RDQ2	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06709	FOS	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	RCA	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00019	Endothelin signaling pathway	P00585	ECE1-3	MOUSE|MGI=MGI=1101357|UniProtKB=Q4PZA2	Endothelin-converting enzyme 1	ISS	94340737	PubMed	PTHR11733:SF130	ENDOTHELIN-CONVERTING ENZYME 1
P00029	Huntington disease	P00805	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04372	5-Hydroxytryptamine degredation	P04401	Monoamine Oxidase	PANTR|Ensembl=ENSPTRG00000021816|UniProtKB=H2QYH5	Amine oxidase [flavin-containing]	ISS	90344230	PubMed	PTHR43563:SF3	AMINE OXIDASE  FLAVIN-CONTAINING  A
P00021	FGF signaling pathway	P00644	p38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00057	Wnt signaling pathway	P01431	LRP5/6	DROME|FlyBase=FBgn0000119|UniProtKB=A1Z9D7	Arrow	IDA	11029006	PubMed	PTHR44017:SF2	ARROW
P00010	B cell activation	P00398	IP3R	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	IGI	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00021	FGF signaling pathway	P00625	MKK3,6	PANTR|Ensembl=ENSPTRG00000009588|UniProtKB=H2QZW5	Mitogen-activated protein kinase kinase 6	RCA			PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P00021	FGF signaling pathway	P00641	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	CHLTR|EnsemblGenome=CT_844|UniProtKB=O84851	tRNA-specific adenosine deaminase	ISS			PTHR11079:SF149	TRNA-SPECIFIC ADENOSINE DEAMINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00059	p53 pathway	G01569	Maspin	MOUSE|MGI=MGI=109579|UniProtKB=P70124	Serpin B5	TAS	10692390	PubMed	PTHR11461:SF55	SERPIN B5
P00048	PI3 kinase pathway	P01199	Galpha	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	HUMAN|HGNC=11541|UniProtKB=Q15545	Transcription initiation factor TFIID subunit 7	ISS			PTHR12228:SF6	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 7
P04393	Ras Pathway	P04541	p90RSK	CHICK|Ensembl=ENSGALG00000016406|UniProtKB=F1NLJ3	Uncharacterized protein	ISS	2779569	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BOVIN|Ensembl=ENSBTAG00000000820|UniProtKB=Q5E9F0	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	ISS			PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	ISS	10974003	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P02748	Isoleucine biosynthesis	P02997	Acetolactate synthase	CRYNJ|EnsemblGenome=CNA02570|UniProtKB=Q5KPJ5	Acetolactate synthase, mitochondrial	ISS			PTHR18968:SF13	ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000012789|UniProtKB=F1MWF5	Uncharacterized protein	ISS	8078925	PubMed	PTHR22968:SF9	SERINE/THREONINE-PROTEIN KINASE D1
P00010	B cell activation	P00371	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MACMU|Ensembl=ENSMMUG00000016815|UniProtKB=F7C9S6	Uncharacterized protein	ISS			PTHR24229:SF52	SOMATOSTATIN RECEPTOR TYPE 4
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT3G59790|UniProtKB=Q9M1Z5	Mitogen-activated protein kinase 10	ISS	10514528	PubMed	PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00005	Angiogenesis	P00226	Delta/Serrate	MONDO|Ensembl=ENSMODG00000004910|UniProtKB=F7C1Q4	Delta-like protein	ISS	10551863	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	176892	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	IPI	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	HUMAN|HGNC=18539|UniProtKB=P61266	Syntaxin-1B	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04397	p53 pathway by glucose deprivation	P04640	p53	RAT|RGD=3889|UniProtKB=P10361	Cellular tumor antigen p53	TAS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	RAT|RGD=619858|UniProtKB=P70579	Metabotropic glutamate receptor 8	IDA			PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00269	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01336	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00053	T cell activation	P01320	PLC-gamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CHICK|Ensembl=ENSGALG00000001334|UniProtKB=F1NLV4	Uncharacterized protein	IC	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05912	Dopamine receptor mediated signaling pathway	P05949	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	11384839	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P02728	Arginine biosynthesis	P02841	argininosuccinate lyase	HUMAN|HGNC=746|UniProtKB=P04424	Argininosuccinate lyase	ISS			PTHR43814:SF1	ARGININOSUCCINATE LYASE
P00024	Glycolysis	P00679	Aldolase	LEIMA|EnsemblGenome=LmjF.36.1260|UniProtKB=Q4Q1V0	Fructose-bisphosphate aldolase	ISS	10551371	PubMed	PTHR11627:SF20	FRUCTOSE-BISPHOSPHATE ALDOLASE
P00036	Interleukin signaling pathway	P00994	FKHRL1	HUMAN|HGNC=3821|UniProtKB=O43524	Forkhead box protein O3	IC	12884295	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00047	PDGF signaling pathway	P01153	GSK3	HUMAN|HGNC=4616|UniProtKB=P49840	Glycogen synthase kinase-3 alpha	ISS	2164470	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P04398	p53 pathway feedback loops 2	P04651	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00047	PDGF signaling pathway	P01140	ELK	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	ISS	10487205	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014555|UniProtKB=F7GT55	Syntaxin-1A isoform 1	ISS	1321498	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00059	p53 pathway	P04609	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00053	T cell activation	P01332	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	IDA	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=3596|UniProtKB=Q9NYQ8	Protocadherin Fat 2	IDA	8120095	PubMed	PTHR24026:SF37	PROTOCADHERIN FAT 2
P04393	Ras Pathway	P04555	PDK	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	11256888	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00049	Parkinson disease	P01211	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	20216076	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	ORNAN|Ensembl=ENSOANG00000002061|UniProtKB=F7ANC6	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	RAT|RGD=69651|UniProtKB=P38438	TGF-beta receptor type-2	TAS	9395284	PubMed	PTHR23255:SF55	TGF-BETA RECEPTOR TYPE-2
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IGI	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00047	PDGF signaling pathway	P01175	Shc	PANTR|Ensembl=ENSPTRG00000021091|UniProtKB=H2QXF3	Uncharacterized protein	ISS	96404502	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MOUSE|MGI=MGI=1341110|UniProtKB=P97490	Adenylate cyclase type 8	IDA	2491850	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347736|UniProtKB=E9FRT1	Muscle-specific actin	ISS	10974003	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00021	FGF signaling pathway	P00623	FGF	PANTR|Ensembl=ENSPTRG00000015746|UniProtKB=H2QNZ3	Fibroblast growth factor	ISS	9232594	PubMed	PTHR11486:SF17	FIBROBLAST GROWTH FACTOR 12
P05916	Opioid prodynorphin pathway	P06002	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00047	PDGF signaling pathway	P01160	IP3 receptor	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00029	Huntington disease	P00778	NMDA receptor	BOVIN|Ensembl=ENSBTAG00000018445|UniProtKB=E1BK87	Uncharacterized protein	ISS	14698601	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00012	Cadherin signaling pathway	P00466	EGFR	MACMU|Ensembl=ENSMMUG00000001674|UniProtKB=F7G3H1	Receptor protein-tyrosine kinase	ISS	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05918	p38 MAPK pathway	P06020	p38delta	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	RCA	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00019	Endothelin signaling pathway	P00591	PLCbeta	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01411	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00015	Circadian clock system	P00504	Per	CHICK|Gene=PER2|UniProtKB=Q8QGQ8	Period circadian protein homolog 2	ISS	21236844	PubMed	PTHR11269:SF9	PERIOD CIRCADIAN PROTEIN HOMOLOG 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TAKRU|Ensembl=ENSTRUG00000004787|UniProtKB=P53480	Actin, alpha cardiac	IC	10974003	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00010	B cell activation	P00377	Ig-beta	HUMAN|HGNC=1699|UniProtKB=P40259	B-cell antigen receptor complex-associated protein beta chain	IDA	11136817	PubMed	PTHR14334:SF2	B-CELL ANTIGEN RECEPTOR COMPLEX-ASSOCIATED PROTEIN BETA CHAIN
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P02759	Pyridoxal-5-phosphate biosynthesis	P03059	Erythronate-4-phosphate dehydrogenase	PSEAE|EnsemblGenome=PA1375|UniProtKB=Q9I3W9	Erythronate-4-phosphate dehydrogenase	ISS			PTHR42938:SF3	ERYTHRONATE-4-PHOSPHATE DEHYDROGENASE
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	RAT|RGD=70487|UniProtKB=Q9WU82	Catenin beta-1	IDA	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P02746	Heme biosynthesis	P02973	Uroporphyrinogen methyltransferase	RHOBA|EnsemblGenome=RB7020|UniProtKB=Q7UPD0	Uroporphyrinogen III synthase/methyltransferase	ISS			PTHR21091:SF16	SIROHEME SYNTHASE
P04393	Ras Pathway	P04542	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	ORNAN|Ensembl=ENSOANG00000000467|UniProtKB=F7F4P1	Uncharacterized protein	ISS	10391901	PubMed	PTHR15936:SF2	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-13
P00049	Parkinson disease	P01226	CDCrel-1	ANOGA|EnsemblGenome=AGAP002645|UniProtKB=Q7QCI4	AGAP002645-PA	IDA			PTHR18884:SF67	SEPTIN-2
P00009	Axon guidance mediated by netrin	P00364	cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	YEAST|SGD=S000001295|UniProtKB=P07278	cAMP-dependent protein kinase regulatory subunit	IC	176892	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	MOUSE|MGI=MGI=88285|UniProtKB=Q91WT9	Cystathionine beta-synthase	ISS			PTHR10314:SF8	CYSTATHIONINE BETA-SYNTHASE-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	RAT|RGD=621060|UniProtKB=O88777	Presenilin-2	IDA	9332390	PubMed	PTHR10202:SF13	PRESENILIN-2
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-040718-134|UniProtKB=Q6DH55	Guanine nucleotide binding protein (G protein), beta polypeptide 3, like	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MACMU|Ensembl=ENSMMUG00000005185|UniProtKB=F7CYN6	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF184	REGULATOR OF G-PROTEIN SIGNALING 4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00564	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	BACSU|EnsemblGenome=BSU00730|UniProtKB=P37887	Cysteine synthase	ISS			PTHR10314:SF133	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01413	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00925	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	DROME|FlyBase=FBgn0020386|UniProtKB=Q9W0V1	3-phosphoinositide-dependent protein kinase 1	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00005	Angiogenesis	P00251	cPLA2	PANTR|Ensembl=ENSPTRG00000001787|UniProtKB=H2Q0T0	Phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00019	Endothelin signaling pathway	P00589	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00819	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04397	p53 pathway by glucose deprivation	P04641	Akt	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	12086862	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00920	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00047	PDGF signaling pathway	P01142	p90RSK	MONDO|Ensembl=ENSMODG00000008086|UniProtKB=F6YJ34	Ribosomal protein S6 kinase	ISS	10558991	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=1336171|UniProtKB=Q9DAS9	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06834	MAP3Ks	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	RCA	11730323	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00047	PDGF signaling pathway	P01142	p90RSK	PANTR|Ensembl=ENSPTRG00000000387|UniProtKB=H2PYE3	Ribosomal protein S6 kinase	ISS	12213813	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00021	FGF signaling pathway	P00642	MEK1-2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00646	RasGAP	BOVIN|Ensembl=ENSBTAG00000005448|UniProtKB=F1N4Y6	Uncharacterized protein	ISS	6635197	gi	PTHR10194:SF4	RAS GTPASE-ACTIVATING PROTEIN 4-RELATED
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	MONDO|Ensembl=ENSMODG00000018065|UniProtKB=F7G485	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	DROME|FlyBase=FBgn0010051|UniProtKB=P29993	Inositol 1,4,5-trisphosphate receptor	IC	11007872	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P06587	Nicotine pharmacodynamics pathway	P06605	KCNK3/9	BOVIN|Ensembl=ENSBTAG00000047488|UniProtKB=G3N1D1	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00029	Huntington disease	P00778	NMDA receptor	MONDO|Ensembl=ENSMODG00000018204|UniProtKB=F6PGX6	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02775	Salvage pyrimidine ribonucleotides	P03156	CDP kinase	ARATH|TAIR=AT1G26190|UniProtKB=Q9C664	Phosphoribulokinase/uridine kinase-like protein	ISS			PTHR10285:SF122	URIDINE-CYTIDINE KINASE C
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00591	PLCbeta	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00004	Alzheimer disease-presenilin pathway	P00131	HAC1	XENTR|Xenbase=XB-GENE-942459|UniProtKB=Q6DJS4	Tripartite motif-containing 2	ISS			PTHR44028:SF2	TRIPARTITE MOTIF-CONTAINING PROTEIN 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	MONDO|Ensembl=ENSMODG00000025146|UniProtKB=F7CLC0	Uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF311	CALMODULIN
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	DANRE|ZFIN=ZDB-GENE-040426-1013|UniProtKB=Q6P0T2	Transcription initiation factor TFIID subunit 8	ISS	604904	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	HUMAN|HGNC=15488|UniProtKB=Q9NPF7	Interleukin-23 subunit alpha	IDA	11114383	PubMed	PTHR15947:SF0	INTERLEUKIN-23 SUBUNIT ALPHA
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	MOUSE|MGI=MGI=1321159|UniProtKB=P63330	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00566	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	18479080	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00025	Hedgehog signaling pathway	P00682	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	MOUSE|MGI=MGI=3609260|UniProtKB=B2RX82	Cholinergic receptor, nicotinic, alpha polypeptide 10	ISS			PTHR18945:SF768	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-10
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01098	CHT1	CAEEL|WormBase=WBGene00000501|UniProtKB=O02228	High-affinity choline transporter 1	RCA			PTHR11819:SF12	HIGH-AFFINITY CHOLINE TRANSPORTER 1
P05913	Enkephalin release	G06046	preproenkephalin mRNA	XENTR|Xenbase=XB-GENE-942760|UniProtKB=F6Y5F6	Uncharacterized protein	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04395	Vasopressin synthesis	P04590	Vasopressin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04393	Ras Pathway	P04570	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04616	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	12855688	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DANRE|ZFIN=ZDB-GENE-040426-1178|UniProtKB=Q7SY24	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	TAS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	PANTR|Gene=CHRM3|UniProtKB=Q9N2A4	Muscarinic acetylcholine receptor M3	ISS	8100450	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04393	Ras Pathway	P04563	Ets	XENTR|Xenbase=XB-GENE-6465484|UniProtKB=B3DM35	LOC100170599 protein	ISS	15298723	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000013632|UniProtKB=E1B965	Uncharacterized protein	ISS	11431030	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00243	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02762	Pentose phosphate pathway	P03070	Gluconate Dehydrogenase	MACMU|Ensembl=ENSMMUG00000023029|UniProtKB=F6VFM9	6-phosphogluconate dehydrogenase, decarboxylating	ISS	8978909	PubMed	PTHR11811:SF25	6-PHOSPHOGLUCONATE DEHYDROGENASE, DECARBOXYLATING
P00010	B cell activation	P00371	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00095	Nicastrin	PANTR|Ensembl=ENSPTRG00000001550|UniProtKB=H2Q0E4	Nicastrin	ISS	10993067	PubMed	PTHR21092:SF0	NICASTRIN
P00036	Interleukin signaling pathway	P00983	Raf	MOUSE|MGI=MGI=88190|UniProtKB=P28028	Serine/threonine-protein kinase B-raf	ISS	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00029	Huntington disease	P00788	Calpain	MOUSE|MGI=MGI=1338030|UniProtKB=Q9R1S8	Calpain-7	IDA	11675509	PubMed	PTHR10183:SF22	CALPAIN-7
P00005	Angiogenesis	P00251	cPLA2	MACMU|Ensembl=ENSMMUG00000021423|UniProtKB=F7EEZ1	Phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00049	Parkinson disease	P01232	CASK	CAEEL|WormBase=WBGene00002991|UniProtKB=P54936	Protein lin-2	IPI	11679592	PubMed	PTHR23122:SF7	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04570	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00932	FAK	CANLF|Ensembl=ENSCAFG00000001217|UniProtKB=E2RGP8	Uncharacterized protein (Fragment)	ISS	9182576	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00048	PI3 kinase pathway	P01192	p110	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00778	NMDA receptor	CHICK|Ensembl=ENSGALG00000011809|UniProtKB=F1NMB0	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00004	Alzheimer disease-presenilin pathway	P00126	Fe65	RAT|RGD=2122|UniProtKB=P46933	Amyloid beta A4 precursor protein-binding family B member 1	IDA	11441186	PubMed	PTHR14058:SF5	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=2683547|UniProtKB=Q4KWH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1	ISS	15611108	PubMed	PTHR10336:SF51	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000020947|UniProtKB=F7CY46	Uncharacterized protein	ISS	12562507	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P00053	T cell activation	P01319	PAK	MONDO|Ensembl=ENSMODG00000005255|UniProtKB=F7G800	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00019	Endothelin signaling pathway	P00590	IP3 R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00034	Integrin signalling pathway	P00927	Rac	ENTHI|EnsemblGenome=EHI_129750|UniProtKB=C4M5Q7	Rho family GTPase	IGI	98264868	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04393	Ras Pathway	P04558	p38	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	8925912	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PHYPA|Gene=PHYPADRAFT_198730|UniProtKB=Q6TYS2	Actin 1	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CAEEL|WormBase=WBGene00000065|UniProtKB=P0DM42	Actin-3	IC	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00024	Glycolysis	P00671	Phosphoglycerate kinase	MONDO|Ensembl=ENSMODG00000025017|UniProtKB=F6SW40	Phosphoglycerate kinase	ISS	79199779	PubMed	PTHR11406:SF0	PHOSPHOGLYCERATE KINASE
P02781	Threonine biosynthesis	P03190	Threonine synthase	NEUCR|EnsemblGenome=EFNCRG00000002573|UniProtKB=Q1K5C3	Threonine synthase	ISS	18376360	gi	PTHR42690:SF1	THREONINE SYNTHASE-LIKE 2
P00017	DNA replication	P00535	5' to 3' Exoribonulcease	ARATH|TAIR=AT1G54490|UniProtKB=Q9FQ04	5'-3' exoribonuclease 4	ISS	4585991	gi	PTHR12341:SF41	5'-3' EXORIBONUCLEASE 2
P00019	Endothelin signaling pathway	P00570	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00029	Huntington disease	P00786	ARF	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g166872|UniProtKB=A7S615	Predicted protein	ISS	11752622	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00021	FGF signaling pathway	P00633	Ras	PANTR|Ensembl=ENSPTRG00000034469|UniProtKB=H2Q2V0	Uncharacterized protein	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00385	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00013	Cell cycle	P00480	Proteasome	ARATH|TAIR=AT5G05780|UniProtKB=O24412	26S proteasome non-ATPase regulatory subunit 7 homolog A	NAS	15229710	gi	PTHR10540:SF7	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	PANTR|Ensembl=ENSPTRG00000016548|UniProtKB=H2QQC5	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00059	p53 pathway	P01486	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00012	Cadherin signaling pathway	P00474	Wnt	MACMU|Ensembl=ENSMMUG00000007765|UniProtKB=F7CW57	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00906	Rap1	MOUSE|MGI=MGI=97855|UniProtKB=Q80ZJ1	Ras-related protein Rap-2a	IC	8576107	PubMed	PTHR24070:SF221	RAS-RELATED PROTEIN RAP-2A
P04398	p53 pathway feedback loops 2	G04709	MDM-2	MOUSE|MGI=MGI=96952|UniProtKB=P23804	E3 ubiquitin-protein ligase Mdm2	IGI	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00034	Integrin signalling pathway	P00910	Grb2	MACMU|Ensembl=ENSMMUG00000005327|UniProtKB=F7GJG7	GRB2-related adapter protein	ISS	8647802	PubMed	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	G04694	p110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00029	Huntington disease	P00774	Dynein complex	MOUSE|MGI=MGI=2135610|UniProtKB=Q8R1Q8	Cytoplasmic dynein 1 light intermediate chain 1	IPI	9454836	PubMed	PTHR12688:SF2	CYTOPLASMIC DYNEIN 1 LIGHT INTERMEDIATE CHAIN 1
P00005	Angiogenesis	P00227	PLA2	MONDO|Ensembl=ENSMODG00000011791|UniProtKB=F7CBU9	Phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00021	FGF signaling pathway	P00643	Raf-1	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS			PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00021	FGF signaling pathway	P00632	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01288	FKBP12	NEUCR|EnsemblGenome=EFNCRG00000003909|UniProtKB=P20080	FK506-binding protein 1A	ISS			PTHR10516:SF347	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	DANRE|ZFIN=ZDB-GENE-030903-5|UniProtKB=Q6EWH2	Tyrosine-protein kinase fyna	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P05913	Enkephalin release	P05972	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00053	T cell activation	P01300	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000024633|UniProtKB=F1MBU9	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CANLF|Ensembl=ENSCAFG00000014987|UniProtKB=E2RH98	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	NEUCR|EnsemblGenome=EFNCRG00000003893|UniProtKB=P78711	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00568	PKC	CAEEL|WormBase=WBGene00018620|UniProtKB=O44588	Uncharacterized protein	ISS	11880265	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01305	Calmodulin	TAKRU|Ensembl=ENSTRUG00000003442|UniProtKB=H2S6Q5	Uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF197	CALMODULIN-LIKE PROTEIN 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00059	p53 pathway	P01482	ARF	BOVIN|Gene=CDKN2B|UniProtKB=Q2KJD8	Cyclin-dependent kinase 4 inhibitor B	ISS			PTHR24148:SF47	CYCLIN-DEPENDENT KINASE 4 INHIBITOR B-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00049	Parkinson disease	P01230	Src kinase	MOUSE|MGI=MGI=95602|UniProtKB=P39688	Tyrosine-protein kinase Fyn	IDA	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00029	Huntington disease	P00796	Kainate receptor	RAT|RGD=2735|UniProtKB=Q63273	Glutamate receptor ionotropic, kainate 5	IDA	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	IC	11035810	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TAKRU|Ensembl=ENSTRUG00000005447|UniProtKB=P68142	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF354	SUBFAMILY NOT NAMED
P00053	T cell activation	P01330	IKK	CANLF|Ensembl=ENSCAFG00000005526|UniProtKB=E2RKR0	Uncharacterized protein	ISS	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00005	Angiogenesis	P00200	Dsh	HUMAN|HGNC=3086|UniProtKB=O14641	Segment polarity protein dishevelled homolog DVL-2	ISS	11212302	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	HUMAN|HGNC=7577|UniProtKB=P12883	Myosin-7	ISS	89264452	PubMed	PTHR13140:SF344	MYOSIN-7
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CHICK|Ensembl=ENSGALG00000008898|UniProtKB=F1P2J9	Uncharacterized protein	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00875	GEF	HUMAN|HGNC=12657|UniProtKB=P15498	Proto-oncogene vav	ISS	14623913	PubMed	PTHR22826:SF112	PROTO-ONCOGENE VAV
P00005	Angiogenesis	P00238	Ras	CHICK|Ensembl=ENSGALG00000006885|UniProtKB=P08642	GTPase HRas	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P06213	DPP signaling pathway	P06290	FUR1	DROME|FlyBase=FBgn0004509|UniProtKB=P26016	Furin-like protease 1, isoforms 1/1-X/2	IEA	10956649	PubMed	PTHR42884:SF3	FURIN-LIKE PROTEASE 1, ISOFORMS 1/1-X/2
P05915	Opioid proenkephalin pathway	P05994	G-protein	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00059	p53 pathway	P04630	PP2A	TAKRU|Ensembl=ENSTRUG00000011169|UniProtKB=H2TU36	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	IC	188830	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01192	p110	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01181	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00021	FGF signaling pathway	P00632	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00559	MEK1-2	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IGI	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	RAT|RGD=2025|UniProtKB=P68136	Actin, alpha skeletal muscle	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P02723	Adenine and hypoxanthine salvage pathway	P02805	Adenine phosphorylase	YEAST|SGD=S000004199|UniProtKB=Q05788	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00018	EGF receptor signaling pathway	P00544	c-Cbl	PANTR|Ensembl=ENSPTRG00000004378|UniProtKB=H2Q4Y2	Cas-Br-M (Murine) ecotropic retroviral transforming sequence	ISS	6680858	gi	PTHR23007:SF5	E3 UBIQUITIN-PROTEIN LIGASE CBL
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00036	Interleukin signaling pathway	P00981	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	MACMU|Ensembl=ENSMMUG00000013100|UniProtKB=F6ZUP6	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF4	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4
P05730	Endogenous cannabinoid signaling	P05751	Galpha	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00005	Angiogenesis	P00226	Delta/Serrate	BOVIN|Ensembl=ENSBTAG00000012817|UniProtKB=E1BDN7	Delta-like protein	ISS	12826675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00047	PDGF signaling pathway	P01173	STAT	HUMAN|HGNC=11367|UniProtKB=P51692	Signal transducer and activator of transcription 5B	ISS	8732682	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00057	Wnt signaling pathway	P01444	Wnt	RAT|RGD=1562253|UniProtKB=D4A3K6	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02738	De novo purine biosynthesis	P02908	Phosphoribosylamine glycine ligase	PANTR|Ensembl=ENSPTRG00000013871|UniProtKB=H2R3B3	Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	ISS			PTHR10520:SF10	TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00047	PDGF signaling pathway	P01153	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00029	Huntington disease	P00778	NMDA receptor	RAT|RGD=2739|UniProtKB=Q00961	Glutamate receptor ionotropic, NMDA 2C	IDA	11554549	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	CANLF|Ensembl=ENSCAFG00000000415|UniProtKB=E2R2K4	Uncharacterized protein	ISS	1904317	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	BOVIN|Ensembl=ENSBTAG00000006582|UniProtKB=E1BFV6	Uncharacterized protein	ISS			PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P05918	p38 MAPK pathway	P06015	p38gamma	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	8925912	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	CAEEL|WormBase=WBGene00001679|UniProtKB=P17343	Guanine nucleotide-binding protein subunit beta-1	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00047	PDGF signaling pathway	P01143	ERK	BOVIN|Ensembl=ENSBTAG00000001014|UniProtKB=A5PKJ4	Mitogen-activated protein kinase 7	ISS	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00012	Cadherin signaling pathway	P00474	Wnt	PANTR|Ensembl=ENSPTRG00000004893|UniProtKB=H2Q5U4	Protein Wnt	ISS	14644163	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	IC	8457205	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P04393	Ras Pathway	P04558	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IDA	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00059	p53 pathway	G04699	BAI-1	CANLF|Ensembl=ENSCAFG00000010872|UniProtKB=F1PXS2	Uncharacterized protein	ISS			PTHR12011:SF41	ADHESION G PROTEIN-COUPLED RECEPTOR B2
P06664	Gonadotropin-releasing hormone receptor pathway	P06827	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	RCA	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CHICK|Ensembl=ENSGALG00000007509|UniProtKB=F1NM72	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P01486	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05760	AC	MACMU|Ensembl=ENSMMUG00000006253|UniProtKB=F7H582	Uncharacterized protein	ISS	92357702	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	PANTR|Ensembl=ENSPTRG00000012547|UniProtKB=H2QIU3	Uncharacterized protein	ISS			PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MOUSE|MGI=MGI=1917446|UniProtKB=Q8R5C5	Beta-centractin	IC	14684598	PubMed	PTHR11937:SF195	BETA-CENTRACTIN
P05915	Opioid proenkephalin pathway	P05989	leu-Enkephalin	DANRE|ZFIN=ZDB-GENE-030729-3|UniProtKB=F1QTD1	Uncharacterized protein (Fragment)	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	IPI	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00036	Interleukin signaling pathway	P00990	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00025	Hedgehog signaling pathway	P00692	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04384	Gamma-aminobutyric acid synthesis	P04480	GABA aminotransferase	MOUSE|MGI=MGI=2443582|UniProtKB=P61922	4-aminobutyrate aminotransferase, mitochondrial	ISS	8133261	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00021	FGF signaling pathway	P00648	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00005	Angiogenesis	P00249	PAK	XENTR|Xenbase=XB-GENE-961764|UniProtKB=F6W3Y0	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IDA	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00049	Parkinson disease	P01211	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00012	Cadherin signaling pathway	P00471	Cadherin	XENTR|Xenbase=XB-GENE-980876|UniProtKB=F7BUJ8	Uncharacterized protein	ISS	8120095	PubMed	PTHR43912:SF5	PROTOCADHERIN-9
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IDA	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	PANTR|Ensembl=ENSPTRG00000023608|UniProtKB=H2QZZ2	Uncharacterized protein	ISS	14698601	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00034	Integrin signalling pathway	P00925	MEK	MOUSE|MGI=MGI=1346869|UniProtKB=P47809	Dual specificity mitogen-activated protein kinase kinase 4	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	BOVIN|Ensembl=ENSBTAG00000011723|UniProtKB=E1BKL6	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00010	B cell activation	P00385	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	20264070	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P02788	Xanthine and guanine salvage pathway	P03245	Guanine phosphoribosyl transferase	STRCO|Gene=CAB42758|UniProtKB=Q9X8I5	Putative hypoxanthine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P06664	Gonadotropin-releasing hormone receptor pathway	P06766	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	RCA	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=2446084|UniProtKB=Q8R5M2	Protein Wnt-9a	IDA	11266476	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	HUMAN|HGNC=10850|UniProtKB=P34896	Serine hydroxymethyltransferase, cytosolic	ISS			PTHR11680:SF21	SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00056	VEGF signaling pathway	P01407	Erk	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00260	AKT	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	ISS	14526383	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02775	Salvage pyrimidine ribonucleotides	P03151	Uracil phosphoribosyl  transferase	HUMAN|HGNC=28334|UniProtKB=Q96BW1	Uracil phosphoribosyltransferase homolog	ISS			PTHR10285:SF90	URACIL PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P06587	Nicotine pharmacodynamics pathway	P06606	ADCY2	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	TAS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00037	Ionotropic glutamate receptor pathway	P01005	NR2D	MOUSE|MGI=MGI=95823|UniProtKB=Q03391	Glutamate receptor ionotropic, NMDA 2D	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00018	EGF receptor signaling pathway	P00557	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00226	Delta/Serrate	HUMAN|HGNC=6188|UniProtKB=P78504	Protein jagged-1	IDA	8955070	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05731	GABA-B receptor II signaling	P05756	GABA-B receptor	MOUSE|MGI=MGI=1860139|UniProtKB=Q9WV18	Gamma-aminobutyric acid type B receptor subunit 1	TAS	9872315	PubMed	PTHR10519:SF42	GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 1
P00029	Huntington disease	P00798	Clathrin	HUMAN|HGNC=2091|UniProtKB=P09497	Clathrin light chain B	ISS	9388255	PubMed	PTHR10639:SF2	CLATHRIN LIGHT CHAIN B
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MONDO|Ensembl=ENSMODG00000018065|UniProtKB=F7G485	Uncharacterized protein	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00005	Angiogenesis	P00243	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	NEUCR|EnsemblGenome=EFNCRG00000000159|UniProtKB=F5HH30	Guanine nucleotide-binding protein beta subunit	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P05916	Opioid prodynorphin pathway	P06002	G-protein	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00036	Interleukin signaling pathway	P00973	PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00057	Wnt signaling pathway	P01457	GBeta	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00047	PDGF signaling pathway	P01153	GSK3	MACMU|Ensembl=ENSMMUG00000014597|UniProtKB=F6VAQ6	Glycogen synthase kinase-3 alpha	ISS	183955	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00047	PDGF signaling pathway	P01148	Grb2	PANTR|Ensembl=ENSPTRG00000016471|UniProtKB=H2QQ79	GRB2-associated binding protein 1	ISS			PTHR12156:SF18	GRB2-ASSOCIATED-BINDING PROTEIN 1
P00012	Cadherin signaling pathway	P00474	Wnt	RAT|RGD=1306312|UniProtKB=D4A9D7	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P00053	T cell activation	P01311	Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	IDA	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00057	Wnt signaling pathway	P01471	alpha-catenin	CANLF|Ensembl=ENSCAFG00000002835|UniProtKB=F1PPY7	Uncharacterized protein	ISS	9362521	PubMed	PTHR18914:SF8	ALPHA-CATULIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ORNAN|Ensembl=ENSOANG00000007581|UniProtKB=F6QWB7	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00021	FGF signaling pathway	P00644	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00010	B cell activation	P00371	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00029	Huntington disease	P00775	Rac	DICDI|dictyBase=DDB_G0282365|UniProtKB=P34146	Rho-related protein rac1C	TAS			PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=2683547|UniProtKB=Q4KWH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1	ISS	7822322	PubMed	PTHR10336:SF51	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-1
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	MOUSE|MGI=MGI=1351342|UniProtKB=Q3UVX5	Metabotropic glutamate receptor 5	ISS	14614461	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	EMENI|EnsemblGenome=CADANIAG00007315|UniProtKB=P20359	Actin, gamma	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00054	Toll receptor signaling pathway	P01369	MKK1	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00005	Angiogenesis	P00203	Erk	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	97442349	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00053	T cell activation	P01324	rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12676940	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00019	Endothelin signaling pathway	P00584	Gs	RAT|RGD=2716|UniProtKB=Q63803	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas	RCA			PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00036	Interleukin signaling pathway	P00981	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	ORNAN|Ensembl=ENSOANG00000009964|UniProtKB=F6QY90	Fructose-bisphosphate aldolase	ISS	8086469	PubMed	PTHR11627:SF2	FRUCTOSE-BISPHOSPHATE ALDOLASE B
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00053	T cell activation	P01331	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IDA	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00012	Cadherin signaling pathway	P00475	Frizzled	CANLF|Gene=FZD6|UniProtKB=Q8WMU5	Frizzled-6	IDA	8717036	PubMed	PTHR11309:SF75	FRIZZLED-6
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CHICK|Ensembl=ENSGALG00000027629|UniProtKB=Q5ZJ03	Guanine nucleotide-binding protein subunit gamma	IDA	11313908	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00029	Huntington disease	P00775	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	15470041	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	MOUSE|MGI=MGI=1913444|UniProtKB=Q9DCC4	Pyrroline-5-carboxylate reductase 3	ISS			PTHR11645:SF22	PYRROLINE-5-CARBOXYLATE REDUCTASE 3
P02738	De novo purine biosynthesis	P02889	dGDP kinase	MACMU|Ensembl=ENSMMUG00000000612|UniProtKB=F7CDE0	Nucleoside diphosphate kinase	ISS			PTHR11349:SF49	NUCLEOSIDE DIPHOSPHATE KINASE, MITOCHONDRIAL
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12701063	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00006	Apoptosis signaling pathway	P00321	HSP70	YEAST|SGD=S000003947|UniProtKB=P10592	Heat shock protein SSA2	ISS	12150907	PubMed	PTHR19375:SF309	HEAT SHOCK PROTEIN SSA1-RELATED
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	PANTR|Ensembl=ENSPTRG00000017730|UniProtKB=H2QSB1	Uncharacterized protein	ISS	12907686	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P02763	Peptidoglycan biosynthesis	P03084	UDP-N-acetylmuramoylalanyl-D-glutamate 2,6-diaminopimelate ligase	THEMA|EnsemblGenome=TM_0237|UniProtKB=Q9WY79	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase	ISS			PTHR23135:SF4	UDP-N-ACETYLMUAMOYLALANYL-D-GLUTAMATE-2,6-DIAMINOPIMELATE LIGASE-RELATED
P00025	Hedgehog signaling pathway	P00690	Cubitus interruptus	CANLF|Ensembl=ENSCAFG00000000223|UniProtKB=E2QZT1	Uncharacterized protein	ISS			PTHR19818:SF2	ZINC FINGER PROTEIN GLI1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DICDI|dictyBase=DDB_G0283907|UniProtKB=P34099	cAMP-dependent protein kinase catalytic subunit	IC	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00053	T cell activation	P01322	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IGI	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00048	PI3 kinase pathway	P01176	JAK	RAT|RGD=2939|UniProtKB=Q62689	Tyrosine-protein kinase JAK2	ISS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	TAS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00018	EGF receptor signaling pathway	P00550	Grb2	DANRE|ZFIN=ZDB-GENE-040426-1975|UniProtKB=Q6PC73	Growth factor receptor-bound protein 2	ISS	http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd	Website	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	MOUSE|MGI=MGI=1916969|UniProtKB=B2RQC6	CAD protein	ISS			PTHR11405:SF5	CAD PROTEIN
P00056	VEGF signaling pathway	P01414	PLC-gamma	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEEL|WormBase=WBGene00018620|UniProtKB=O44588	Uncharacterized protein	ISS	15572354	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P00034	Integrin signalling pathway	P00924	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05977	G-Protein (s)	DANRE|ZFIN=ZDB-GENE-040718-93|UniProtKB=Q6DGZ5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00021	FGF signaling pathway	P00642	MEK1-2	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IGI	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00059	p53 pathway	G04703	Apaf	PANTR|Ensembl=ENSPTRG00000005335|UniProtKB=H2R1S6	Apoptotic protease-activating factor 1	ISS	9267021	PubMed	PTHR22845:SF5	APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
P00006	Apoptosis signaling pathway	P00260	AKT	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	12655147	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	LEIMA|EnsemblGenome=LmjF.32.2950|UniProtKB=Q9U1E1	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00634	MEKK1-5	PANTR|Ensembl=ENSPTRG00000016891|UniProtKB=H2R5K3	Uncharacterized protein	ISS	8940199	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00006	Apoptosis signaling pathway	P00272	ASK1	HUMAN|HGNC=6857|UniProtKB=Q99683	Mitogen-activated protein kinase kinase kinase 5	IDA	12968034	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P04393	Ras Pathway	P04550	Ral	PANTR|Ensembl=ENSPTRG00000019108|UniProtKB=H2QUG6	Uncharacterized protein	ISS	11025226	PubMed	PTHR24070:SF174	RAS-RELATED PROTEIN RAL-A
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IDA	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	RAT|RGD=2089|UniProtKB=P05065	Fructose-bisphosphate aldolase A	ISS	84261525	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00054	Toll receptor signaling pathway	P01358	ERK1	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00053	T cell activation	P01322	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	MACMU|Ensembl=ENSMMUG00000001849|UniProtKB=F7GQQ8	Interleukin-5 receptor subunit alpha	ISS	1732409	PubMed	PTHR23036:SF17	INTERLEUKIN-5 RECEPTOR SUBUNIT ALPHA
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00638	PLCgamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01162	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ANOGA|EnsemblGenome=AGAP006521|UniProtKB=Q7Q5C3	AGAP006521-PA	IC	14765990	PubMed	PTHR10218:SF229	GUANINE NUCLEOTIDE-BINDING PROTEIN G F  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00114	actin	HUMAN|HGNC=169|UniProtKB=P61160	Actin-related protein 2	IDA	10974003	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00049	Parkinson disease	P01211	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00059	p53 pathway	P04633	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04395	Vasopressin synthesis	P04589	Signal Peptidase	BOVIN|Ensembl=ENSBTAG00000006644|UniProtKB=E1BEI2	Uncharacterized protein	ISS	2092035	PubMed	PTHR13085:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 2
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00029	Huntington disease	P00763	Hip-12	PANTR|Ensembl=ENSPTRG00000005586|UniProtKB=H2Q750	Uncharacterized protein	RCA			PTHR10407:SF10	HUNTINGTIN-INTERACTING PROTEIN 1-RELATED PROTEIN
P00034	Integrin signalling pathway	P00925	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000022319|UniProtKB=F6XDA0	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00034	Integrin signalling pathway	P00941	Integrin alpha	HUMAN|HGNC=6150|UniProtKB=P06756	Integrin alpha-V	IPI	3487386	PubMed	PTHR23220:SF4	INTEGRIN ALPHA-V
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	HUMAN|HGNC=11589|UniProtKB=P62380	TATA box-binding protein-like protein 1	ISS	10082669	PubMed	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00059	p53 pathway	P04633	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00025	Hedgehog signaling pathway	P00687	Cubitus interruptus repressor	PANTR|Gene=GLI3|UniProtKB=Q5IS56	Transcriptional activator GLI3	ISS	15994174	PubMed	PTHR19818:SF5	TRANSCRIPTIONAL ACTIVATOR GLI3
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	CANLF|Ensembl=ENSCAFG00000010255|UniProtKB=E2RPY4	Uncharacterized protein	ISS	12374786	PubMed	PTHR11767:SF52	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 4
P00019	Endothelin signaling pathway	P00589	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	94280860	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P02738	De novo purine biosynthesis	P02907	dADP kinase	HUMAN|HGNC=7849|UniProtKB=P15531	Nucleoside diphosphate kinase A	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	THEKO|EnsemblGenome=TK1796|UniProtKB=O08467	Glutamine synthetase	ISS			PTHR43785:SF1	TYPE-1 GLUTAMINE SYNTHETASE 2
P00004	Alzheimer disease-presenilin pathway	P00146	Afadin	MACMU|Ensembl=ENSMMUG00000021044|UniProtKB=F7HG05	Uncharacterized protein	ISS	10974003	PubMed	PTHR10398:SF1	AFADIN
P00053	T cell activation	P01333	cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00890	ELK	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	ISS	14670631	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01457	GBeta	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00244	MAPKAPK2/3	MACMU|Ensembl=ENSMMUG00000023567|UniProtKB=F7HHY8	Uncharacterized protein	ISS	10779545	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	BOVIN|Ensembl=ENSBTAG00000013632|UniProtKB=E1B965	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05913	Enkephalin release	P05972	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00560	Raf-1	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS			PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IDA	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	YEAST|SGD=S000004716|UniProtKB=Q04458	Fatty aldehyde dehydrogenase HFD1	IC			PTHR43570:SF16	ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=88398|UniProtKB=Q9ERZ3	Muscarinic acetylcholine receptor M3	IDA			PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	TAKRU|Ensembl=ENSTRUG00000015959|UniProtKB=H2UV27	Uncharacterized protein	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00048	PI3 kinase pathway	P01177	P110ACT	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04559	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	PHYPA|Gene=PHYPADRAFT_144700|UniProtKB=A9TFB1	Predicted protein	ISS			PTHR23073:SF7	26S PROTEASE REGULATORY SUBUNIT 6A
P00010	B cell activation	P00383	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00507	Rho	MONDO|Ensembl=ENSMODG00000000981|UniProtKB=F7ES59	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P05915	Opioid proenkephalin pathway	P05994	G-protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01284	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00018	EGF receptor signaling pathway	P00564	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS			PTHR13808:SF5	CREB-BINDING PROTEIN
P02775	Salvage pyrimidine ribonucleotides	P03149	Cytidine kinase	RAT|RGD=620742|UniProtKB=Q9QYG8	Uridine-cytidine kinase 2	ISS			PTHR10285:SF70	URIDINE-CYTIDINE KINASE 2
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	PANTR|Ensembl=ENSPTRG00000018361|UniProtKB=P60020	5-hydroxytryptamine receptor 1B	ISS	12181435	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P00018	EGF receptor signaling pathway	P00547	PP2A	CANLF|Ensembl=ENSCAFG00000006453|UniProtKB=F6X958	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06779	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	RCA	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04570	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01161	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00576	Pre-pro ET1-4	MOUSE|MGI=MGI=95283|UniProtKB=P22387	Endothelin-1	ISS	12893655	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	IC	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00002	Alpha adrenergic receptor signaling pathway	P00078	Alpha1A/1B/1C	MOUSE|MGI=MGI=104773|UniProtKB=P97718	Alpha-1A adrenergic receptor	IC	6323229	PubMed	PTHR24248:SF16	ALPHA-1A ADRENERGIC RECEPTOR
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00048	PI3 kinase pathway	P01192	p110	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00021	FGF signaling pathway	P00632	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00189	Fzd	HUMAN|HGNC=4038|UniProtKB=Q9UP38	Frizzled-1	IDA	11212302	PubMed	PTHR11309:SF81	FRIZZLED-1
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	IPI	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00046	Oxidative stress response	P01134	cPLA2	MONDO|Ensembl=ENSMODG00000011791|UniProtKB=F7CBU9	Phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00059	p53 pathway	P04633	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00020	FAS signaling pathway	P00616	Nuclear Lamin	HUMAN|HGNC=6637|UniProtKB=P20700	Lamin-B1	TAS	11165516	PubMed	PTHR23239:SF157	LAMIN-B1
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT3G59790|UniProtKB=Q9M1Z5	Mitogen-activated protein kinase 10	ISS	12787066	PubMed	PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	STRPU|EnsemblGenome=SPU_017814|UniProtKB=W4YPT6	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF263	SUBFAMILY NOT NAMED
P00010	B cell activation	P00371	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	MACMU|Ensembl=ENSMMUG00000017431|UniProtKB=F7HPP3	Uncharacterized protein	ISS	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00006	Apoptosis signaling pathway	P00269	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	MACMU|Ensembl=ENSMMUG00000022224|UniProtKB=F6Z890	Interleukin-13 receptor subunit alpha-2	ISS	12816724	PubMed	PTHR23036:SF101	INTERLEUKIN-13 RECEPTOR SUBUNIT ALPHA-2
P00056	VEGF signaling pathway	P01420	FAK	BOVIN|Ensembl=ENSBTAG00000009578|UniProtKB=G3N3B7	Uncharacterized protein	ISS	12640026	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01465	Ggamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00060	Ubiquitin proteasome pathway	P01490	E3	HUMAN|HGNC=17004|UniProtKB=Q9H0M0	NEDD4-like E3 ubiquitin-protein ligase WWP1	ISS			PTHR11254:SF299	NEDD4-LIKE E3 UBIQUITIN-PROTEIN LIGASE WWP1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	ANOGA|EnsemblGenome=AGAP006027|UniProtKB=Q7PNT0	AGAP006027-PA	ISS	10331083	PubMed	PTHR18966:SF270	GLUTAMATE RECEPTOR 1-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000008714|UniProtKB=F7E1N0	Adenosine receptor A1	ISS	11781138	PubMed	PTHR24246:SF1	ADENOSINE RECEPTOR A1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00790	beta-Tubulin	CAEEL|WormBase=WBGene00003171|UniProtKB=P12456	Tubulin beta-1 chain	TAS	12932731	PubMed	PTHR11588:SF255	TUBA7L PROTEIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04376	5HT4 type receptor mediated signaling pathway	P04431	5HT transporter	BOVIN|Gene=SLC6A4|UniProtKB=Q9XT49	Sodium-dependent serotonin transporter	ISS	7681602	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P00019	Endothelin signaling pathway	P00577	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01432	Beta-Catenin	ORNAN|Ensembl=ENSOANG00000006811|UniProtKB=F6WBD5	Uncharacterized protein	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P05913	Enkephalin release	P05977	G-Protein (s)	ARATH|TAIR=AT4G34460|UniProtKB=P49177	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF48	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA
P00011	Blood coagulation	P00429	PN2	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	ISS	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00010	B cell activation	P00383	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05915	Opioid proenkephalin pathway	P05994	G-protein	DROME|FlyBase=FBgn0030011|UniProtKB=Q9W3J1	Gbeta5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00021	FGF signaling pathway	P00634	MEKK1-5	MOUSE|MGI=MGI=1346873|UniProtKB=Q61083	Mitogen-activated protein kinase kinase kinase 2	ISS	8649450	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00037	Ionotropic glutamate receptor pathway	P01006	NR2C	HUMAN|HGNC=4587|UniProtKB=Q14957	Glutamate receptor ionotropic, NMDA 2C	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P02755	Methylmalonyl pathway	P03034	Methylmalonyl-CoA mutase	HUMAN|HGNC=7526|UniProtKB=P22033	Methylmalonyl-CoA mutase, mitochondrial	ISS			PTHR42710:SF1	METHYLMALONYL-COA MUTASE, MITOCHONDRIAL
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CAEEL|WormBase=WBGene00006454|UniProtKB=G5EEN8	AEX-4	IC			PTHR19305:SF10	AEX-4
P02738	De novo purine biosynthesis	P02902	ADP reductase	PANTR|Ensembl=ENSPTRG00000003207|UniProtKB=H2Q2Y0	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	DANRE|ZFIN=ZDB-GENE-020503-2|UniProtKB=B0R0Q2	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF498	TYROSINE-PROTEIN KINASE RECEPTOR
P04380	Cortocotropin releasing factor receptor signaling pathway	P04452	proopiomelanocortin	HUMAN|HGNC=9201|UniProtKB=P01189	Pro-opiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00029	Huntington disease	P00771	Sin3A	MOUSE|MGI=MGI=107157|UniProtKB=Q60520	Paired amphipathic helix protein Sin3a	IDA	10441327	PubMed	PTHR12346:SF2	PAIRED AMPHIPATHIC HELIX PROTEIN SIN3A
P00057	Wnt signaling pathway	P01435	SWI/SNF	PANTR|Ensembl=ENSPTRG00000012898|UniProtKB=H2R0H8	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1	ISS	11532957	PubMed	PTHR10799:SF731	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A-LIKE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT1G10210|UniProtKB=Q39021	Mitogen-activated protein kinase 1	ISS	176948	OMIM	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	IDA	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	STRCO|EnsemblGenome=CAB38500|UniProtKB=Q9X928	Acetyl-coenzyme A synthetase	ISS			PTHR24095:SF14	ACETYL-COENZYME A SYNTHETASE 1
P00057	Wnt signaling pathway	P01435	SWI/SNF	HUMAN|HGNC=16974|UniProtKB=Q6ZRS2	Helicase SRCAP	IDA	11532957	PubMed	PTHR10799:SF935	HELICASE SRCAP
P00021	FGF signaling pathway	P00632	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00019	Endothelin signaling pathway	P00591	PLCbeta	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00056	VEGF signaling pathway	P01407	Erk	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00260	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	ARATH|TAIR=AT1G04440|UniProtKB=Q5XF24	At1g04440	IDA	11437445	PubMed	PTHR11909:SF178	CASEIN KINASE 1-LIKE PROTEIN 8
P00021	FGF signaling pathway	P00626	Spry	PANTR|Ensembl=ENSPTRG00000005951|UniProtKB=H2Q7P2	Sprouty homolog 2	ISS	12225946	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P00029	Huntington disease	P00777	CBP	HUMAN|HGNC=3373|UniProtKB=Q09472	Histone acetyltransferase p300	IDA	10823891	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00013	Cell cycle	P00484	Cyclin D	MACMU|Ensembl=ENSMMUG00000002368|UniProtKB=F7BZY1	Uncharacterized protein	ISS	93330551	PubMed	PTHR10177:SF67	G1/S-SPECIFIC CYCLIN-D1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	ANOGA|EnsemblGenome=AGAP005913|UniProtKB=Q7Q6D2	AGAP005913-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00004	Alzheimer disease-presenilin pathway	P00178	BACE-1 pro-domain	MOUSE|MGI=MGI=1346542|UniProtKB=P56818	Beta-secretase 1	IDA	10531052	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00056	VEGF signaling pathway	P01420	FAK	MOUSE|MGI=MGI=95481|UniProtKB=P34152	Focal adhesion kinase 1	ISS	9182576	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00010	B cell activation	P00372	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	8235613	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00005	Angiogenesis	P00238	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00004	Alzheimer disease-presenilin pathway	P00118	E-cadherin	HUMAN|HGNC=1748|UniProtKB=P12830	Cadherin-1	IDA	12834808	PubMed	PTHR24027:SF319	CADHERIN-1
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00021	FGF signaling pathway	P00627	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	13620175	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00019	Endothelin signaling pathway	P00586	Gq	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05918	p38 MAPK pathway	P06017	MNK2	MACMU|Ensembl=ENSMMUG00000011265|UniProtKB=F6WP09	Uncharacterized protein	ISS	11463832	PubMed	PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P00021	FGF signaling pathway	P00628	JNK1-3	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	SCHPO|PomBase=SPAC3A12.17c|UniProtKB=P87131	Cysteine synthase 2	ISS			PTHR10314:SF35	CYSTEINE SYNTHASE-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DROME|FlyBase=FBgn0000489|UniProtKB=P16912	Protein kinase DC2	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00021	FGF signaling pathway	P00647	SHP2	PANTR|Ensembl=ENSPTRG00000042397|UniProtKB=H2RIH8	Tyrosine-protein phosphatase non-receptor type	ISS	14534538	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00203	Erk	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00005	Angiogenesis	P00188	Ets	MONDO|Ensembl=ENSMODG00000004730|UniProtKB=F6Y1Z2	Uncharacterized protein	ISS	15699632	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00021	FGF signaling pathway	P00638	PLCgamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00013	Cell cycle	P00484	Cyclin D	RAT|RGD=68384|UniProtKB=P39948	G1/S-specific cyclin-D1	ISS	12356903	PubMed	PTHR10177:SF67	G1/S-SPECIFIC CYCLIN-D1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	HUMAN|HGNC=1402|UniProtKB=Q08289	Voltage-dependent L-type calcium channel subunit beta-2	IC	20088160	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00047	PDGF signaling pathway	P01167	Ets	MOUSE|MGI=MGI=1928377|UniProtKB=Q9Z2U4	ETS-related transcription factor Elf-4	ISS	15298723	PubMed	PTHR11849:SF170	ETS-RELATED TRANSCRIPTION FACTOR ELF-4
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04395	Vasopressin synthesis	P04589	Signal Peptidase	CANLF|Ensembl=ENSCAFG00000032663|UniProtKB=Q28250	Signal peptidase complex subunit 2	ISS	7788527	PubMed	PTHR13085:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 2
P00053	T cell activation	P01332	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P06959	CCKR signaling map	P07162	PDPK1	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	RCA	10455013	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	IPI	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00049	Parkinson disease	P01212	p38 MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	NAS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04398	p53 pathway feedback loops 2	P04665	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=17293|UniProtKB=Q9BZL6	Serine/threonine-protein kinase D2	IGI	11062248	PubMed	PTHR22968:SF12	SERINE/THREONINE-PROTEIN KINASE D2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MACMU|Ensembl=ENSMMUG00000007027|UniProtKB=F7F210	Alpha-cardiac actin	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	ARATH|TAIR=AT4G01370|UniProtKB=Q39024	Mitogen-activated protein kinase 4	TAS			PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00034	Integrin signalling pathway	P00916	Ras	MONDO|Gene=KRAS|UniProtKB=Q07983	GTPase KRas	ISS	3023884	PubMed	PTHR24070:SF186	GTPASE KRAS
P00021	FGF signaling pathway	P00629	PP2A	MOUSE|MGI=MGI=2388481|UniProtKB=Q91V89	Protein Ppp2r5d	ISS	12110603	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	TAS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00019	Endothelin signaling pathway	P00577	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00547	PP2A	PANTR|Ensembl=ENSPTRG00000017238|UniProtKB=H2QRH7	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	RAT|RGD=620003|UniProtKB=O08773	Regulator of G-protein signaling 14	IDA	8756726	PubMed	PTHR10845:SF179	REGULATOR OF G-PROTEIN SIGNALING 14
P04393	Ras Pathway	P04551	RalGDS	PANTR|Ensembl=ENSPTRG00000018042|UniProtKB=H2QST2	Ral guanine nucleotide dissociation stimulator-like 2	ISS	8939933	PubMed	PTHR23113:SF213	RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 2
P00046	Oxidative stress response	P01129	JNK1/2	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05915	Opioid proenkephalin pathway	P05994	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MONDO|Ensembl=ENSMODG00000010521|UniProtKB=F7DQK7	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00053	T cell activation	P01332	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IDA	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04565	MKK4/7	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00021	FGF signaling pathway	P00643	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04653	cdk2	CANLF|Ensembl=ENSCAFG00000000082|UniProtKB=E2QW70	Uncharacterized protein	ISS	1846803	PubMed	PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	RAT|RGD=61953|UniProtKB=Q64303	Serine/threonine-protein kinase PAK 2	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00029	Huntington disease	P00774	Dynein complex	BOVIN|Ensembl=ENSBTAG00000016598|UniProtKB=E1BDX8	Uncharacterized protein	ISS	9454836	PubMed	PTHR10676:SF314	CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01319	PAK	MOUSE|MGI=MGI=1339975|UniProtKB=O88643	Serine/threonine-protein kinase PAK 1	IDA	14580336	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00059	p53 pathway	G01572	NOXA	RAT|RGD=1304964|UniProtKB=D4AA14	Protein Aifm2	ISS			PTHR43735:SF9	APOPTOSIS-INDUCING FACTOR 2
P00053	T cell activation	P01322	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04567	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	IDA	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P04398	p53 pathway feedback loops 2	P04657	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00203	Erk	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00771	Sin3A	XENTR|Xenbase=XB-GENE-480875|UniProtKB=F6TAI6	Uncharacterized protein	ISS	10441327	PubMed	PTHR12346:SF2	PAIRED AMPHIPATHIC HELIX PROTEIN SIN3A
P00046	Oxidative stress response	P01131	MKP5	CANLF|Ensembl=ENSCAFG00000019241|UniProtKB=E2R4V2	Dual specificity protein phosphatase	ISS			PTHR10159:SF388	DUAL SPECIFICITY PROTEIN PHOSPHATASE 9
P00036	Interleukin signaling pathway	P00976	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00017	DNA replication	P00527	Histones	ARATH|TAIR=AT5G65350|UniProtKB=Q9FKQ3	Histone H3-like 5	ISS	12413958	PubMed	PTHR11426:SF172	HISTONE H3-LIKE 5-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04393	Ras Pathway	P04557	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	RAT|RGD=2342|UniProtKB=P08482	Muscarinic acetylcholine receptor M1	TAS	10069496	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MOUSE|MGI=MGI=87905|UniProtKB=P68033	Actin, alpha cardiac muscle 1	IDA	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	RAT|RGD=2917|UniProtKB=P15127	Insulin receptor	ISS	249616	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	ARATH|TAIR=AT1G08730|UniProtKB=F4HXP9	Myosin-9	IC			PTHR13140:SF706	UNCONVENTIONAL MYOSIN-VI
P00034	Integrin signalling pathway	P00923	Arf1	CHICK|Ensembl=ENSGALG00000011651|UniProtKB=E1BVB0	Uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	HUMAN|HGNC=2509|UniProtKB=P35221	Catenin alpha-1	TAS	1904011	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	MACMU|Ensembl=ENSMMUG00000018571|UniProtKB=F6YLU2	Uncharacterized protein	ISS	123810	OMIM	PTHR22952:SF24	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 1
P00045	Notch signaling pathway	P01110	Presenilin	PANTR|Ensembl=ENSPTRG00000006510|UniProtKB=H2Q8K1	Presenilin	ISS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	IC	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00049	Parkinson disease	P01208	Hsp70	HUMAN|HGNC=5232|UniProtKB=P0DMV8	Heat shock 70 kDa protein 1A	IDA	12150907	PubMed	PTHR19375:SF223	HEAT SHOCK 70 KDA PROTEIN 1A-RELATED
P00036	Interleukin signaling pathway	P00976	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g234494|UniProtKB=A7RU31	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00048	PI3 kinase pathway	P01188	Gbetagamma	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	IDA	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00029	Huntington disease	P00800	PolyQ Htt	RAT|RGD=68337|UniProtKB=P51111	Huntingtin	TAS	8268927	PubMed	PTHR10170:SF10	HUNTINGTIN
P00011	Blood coagulation	P00411	PAI-1	HUMAN|HGNC=8583|UniProtKB=P05121	Plasminogen activator inhibitor 1	ISS	10692390	PubMed	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00006	Apoptosis signaling pathway	P00310	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MACMU|Gene=CXCR4|UniProtKB=P79394	C-X-C chemokine receptor type 4	ISS	11943720	PubMed	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000006342|UniProtKB=H2Q8A8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00059	p53 pathway	P04609	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	1171954	gi	PTHR10048:SF14	PI-3 KINASE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01160	IP3 receptor	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04393	Ras Pathway	P04572	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00053	T cell activation	P01294	NFAT	RAT|RGD=1307690|UniProtKB=D4A0I8	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (Predicted), isoform CRA_b	ISS	12015605	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02748	Isoleucine biosynthesis	P02996	Ketol-acid reductoisomerase	ARATH|TAIR=AT3G58610|UniProtKB=Q05758	Ketol-acid reductoisomerase, chloroplastic	ISS			PTHR21371:SF1	KETOL-ACID REDUCTOISOMERASE, CHLOROPLASTIC
P00003	Alzheimer disease-amyloid secretase pathway	P00092	TACE	RAT|RGD=620404|UniProtKB=Q9Z1K9	Disintegrin and metalloproteinase domain-containing protein 17	IDA	12834808	PubMed	PTHR11905:SF171	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17
P05731	GABA-B receptor II signaling	P05760	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	RCA	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00029	Huntington disease	P00807	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g210933|UniProtKB=A7SEA7	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04485	H1	MOUSE|MGI=MGI=107619|UniProtKB=P70174	Histamine H1 receptor	ISS	11841575	PubMed	PTHR43914:SF2	HISTAMINE H1 RECEPTOR
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00011	Blood coagulation	P00406	Fibrinogen	PANTR|Ensembl=ENSPTRG00000016534|UniProtKB=H2QQB4	Uncharacterized protein	ISS	11761631	gi	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CAEEL|WormBase=WBGene00001187|UniProtKB=Q8MQA1	Uncharacterized protein	IC	11956331	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	ISS	176892	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04393	Ras Pathway	P04572	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IGI	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	TAS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00049	Parkinson disease	P01227	20S proteasome	DROME|FlyBase=FBgn0086134|UniProtKB=P40301	Proteasome subunit alpha type-2	TAS	12859888	PubMed	PTHR11599:SF16	PROTEASOME SUBUNIT ALPHA TYPE-2
P00057	Wnt signaling pathway	P01443	Phospholipase C	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04398	p53 pathway feedback loops 2	P04657	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00231	HSP27	BOVIN|Ensembl=ENSBTAG00000000440|UniProtKB=F1MBR1	Heat shock 27kDa protein 2	ISS			PTHR11527:SF163	HEAT SHOCK PROTEIN BETA-2
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04397	p53 pathway by glucose deprivation	P04641	Akt	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	ISS	95181376	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00376	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	RAT|RGD=3425|UniProtKB=P97887	Presenilin-1	IDA	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00011	Blood coagulation	P00411	PAI-1	MACMU|Ensembl=ENSMMUG00000009926|UniProtKB=F6Y5D7	Uncharacterized protein	ISS	18092159	gi	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00019	Endothelin signaling pathway	P00586	Gq	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00049	Parkinson disease	P01211	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00645	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12912997	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P04398	p53 pathway feedback loops 2	P04665	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01208	Hsp70	MYCTU|EnsemblGenome=Rv0350|UniProtKB=P9WMJ9	Chaperone protein DnaK	ISS	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00010	B cell activation	P00373	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IGI	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00021	FGF signaling pathway	P00623	FGF	CANLF|Ensembl=ENSCAFG00000014923|UniProtKB=P79150	Fibroblast growth factor 7	ISS	14527678	PubMed	PTHR11486:SF20	FIBROBLAST GROWTH FACTOR 7
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00018	EGF receptor signaling pathway	P00552	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P02757	O-antigen biosynthesis	P03045	dTDP-glucose 4,6-dehydratase	RHOBA|EnsemblGenome=RB2507|UniProtKB=Q7UVP4	dTDP-glucose 4,6-dehydratase	ISS			PTHR43000:SF14	DTDP-GLUCOSE 4,6-DEHYDRATASE 2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	CHICK|Gene=PSEN2|UniProtKB=Q90X07	Presenilin-2	IDA	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DROME|FlyBase=FBgn0001105|UniProtKB=P26308	Guanine nucleotide-binding protein subunit beta-1	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P02738	De novo purine biosynthesis	P02908	Phosphoribosylamine glycine ligase	ARATH|TAIR=AT1G09830|UniProtKB=P52420	Phosphoribosylamine--glycine ligase, chloroplastic	ISS			PTHR43472:SF2	PHOSPHORIBOSYLAMINE--GLYCINE LIGASE, CHLOROPLASTIC
P00054	Toll receptor signaling pathway	P01375	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00049	Parkinson disease	P01227	20S proteasome	MONDO|Ensembl=ENSMODG00000012614|UniProtKB=F6S2Q4	Proteasome subunit beta type	ISS	12859888	PubMed	PTHR11599:SF62	PROTEASOME SUBUNIT BETA TYPE-3
P04393	Ras Pathway	P04552	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00021	FGF signaling pathway	P00629	PP2A	CHICK|Gene_ORFName=RCJMB04_22l15|UniProtKB=Q5ZIY5	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform	ISS	11956189	PubMed	PTHR11871:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B DELTA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00548	RKIP	MACMU|Ensembl=ENSMMUG00000018345|UniProtKB=F7H656	Uncharacterized protein	ISS			PTHR11362:SF70	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4
P05913	Enkephalin release	P05972	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	10218114	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01311	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00021	FGF signaling pathway	P00633	Ras	CHICK|Ensembl=ENSGALG00000006885|UniProtKB=P08642	GTPase HRas	ISS	3035212	PubMed	PTHR24070:SF385	GTPASE HRAS
P04393	Ras Pathway	P04552	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02763	Peptidoglycan biosynthesis	P03092	Phospho-N-acetylmuramoyl pentapeptide transferase	THEMA|EnsemblGenome=TM_0235|UniProtKB=Q9WY77	Phospho-N-acetylmuramoyl-pentapeptide-transferase	ISS			PTHR22926:SF5	PHOSPHO-N-ACETYLMURAMOYL-PENTAPEPTIDE-TRANSFERASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00036	Interleukin signaling pathway	P00994	FKHRL1	MOUSE|MGI=MGI=1890081|UniProtKB=Q9WVH4	Forkhead box protein O3	IPI	12048180	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00034	Integrin signalling pathway	P00927	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04398	p53 pathway feedback loops 2	P04665	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00013	Cell cycle	P00485	Cdk2	MACMU|Ensembl=ENSMMUG00000003483|UniProtKB=F7E7R7	Uncharacterized protein	ISS	12477932	PubMed	PTHR15827:SF2	CYCLIN-DEPENDENT KINASE 2-INTERACTING PROTEIN
P05915	Opioid proenkephalin pathway	P05994	G-protein	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00029	Huntington disease	P00799	JNK-2	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DICDI|dictyBase=DDB_G0283907|UniProtKB=P34099	cAMP-dependent protein kinase catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MONDO|Ensembl=ENSMODG00000000771|UniProtKB=F6SSS3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00053	T cell activation	P01306	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	ANOGA|EnsemblGenome=AGAP006475|UniProtKB=Q5TQX0	AGAP006475-PA	ISS	11007872	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P04393	Ras Pathway	P04546	GSK3	BOVIN|Ensembl=ENSBTAG00000020756|UniProtKB=A6QLB8	GSK3A protein	ISS	21361340	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	15737619	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00048	PI3 kinase pathway	P01179	PKB	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	ORYSJ|EnsemblGenome=OS05G0438800|UniProtKB=Q75HX0	Actin	IC	14684598	PubMed	PTHR11937:SF248	SUBFAMILY NOT NAMED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P06664	Gonadotropin-releasing hormone receptor pathway	G06680	c-fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	RCA	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00034	Integrin signalling pathway	P00925	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IDA	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02738	De novo purine biosynthesis	P02907	dADP kinase	PANTR|Ensembl=ENSPTRG00000005528|UniProtKB=H2Q705	Nucleoside diphosphate kinase	ISS			PTHR11349:SF68	NUCLEOSIDE DIPHOSPHATE KINASE-RELATED
P00047	PDGF signaling pathway	P01173	STAT	CANLF|Ensembl=ENSCAFG00000015346|UniProtKB=E2RE22	Signal transducer and activator of transcription	ISS	95188889	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	DANRE|ZFIN=ZDB-GENE-990415-166|UniProtKB=P79737	GTPase NRas	ISS	9116869	PubMed	PTHR24070:SF189	GTPASE NRAS
P00029	Huntington disease	P00796	Kainate receptor	BOVIN|Ensembl=ENSBTAG00000034854|UniProtKB=F1N246	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	CANLF|Ensembl=ENSCAFG00000018704|UniProtKB=Q9N280	Na+-dependent glutamate transporter	ISS	94365697	PubMed	PTHR11958:SF24	EXCITATORY AMINO ACID TRANSPORTER 1
P00029	Huntington disease	G01533	Bax	XENTR|Xenbase=XB-GENE-486067|UniProtKB=Q6P4Y4	BCL2-associated X protein	ISS	11099028	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	10514528	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	RAT|RGD=61953|UniProtKB=Q64303	Serine/threonine-protein kinase PAK 2	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MOUSE|MGI=MGI=87909|UniProtKB=P62737	Actin, aortic smooth muscle	IC	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00037	Ionotropic glutamate receptor pathway	P01006	NR2C	MOUSE|MGI=MGI=95823|UniProtKB=Q03391	Glutamate receptor ionotropic, NMDA 2D	ISS			PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000014675|UniProtKB=H2QM57	Phosphoinositide phospholipase C	ISS			PTHR10336:SF84	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2
P00018	EGF receptor signaling pathway	P00561	STAT	PANTR|Ensembl=ENSPTRG00000009199|UniProtKB=H2QD19	Signal transducer and activator of transcription	ISS	14662325	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00057	Wnt signaling pathway	P01456	beta-arrestin	MOUSE|MGI=MGI=2159617|UniProtKB=Q9EQP6	Arrestin-C	IC	11742073	PubMed	PTHR11792:SF19	ARRESTIN-C
P00034	Integrin signalling pathway	P00941	Integrin alpha	RAT|RGD=1305152|UniProtKB=D3ZW82	Protein Itga10	ISS	3487386	PubMed	PTHR23220:SF26	INTEGRIN ALPHA-10
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00019	Endothelin signaling pathway	P00589	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01408	Akt/PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00029	Huntington disease	P00779	TBP	METAC|EnsemblGenome=MA_0278|UniProtKB=Q8TTZ7	TATA-box-binding protein 3	IPI	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00049	Parkinson disease	P01211	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04572	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	CANLF|Ensembl=ENSCAFG00000000828|UniProtKB=F6UWI0	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=109211|UniProtKB=Q8BWW9	Serine/threonine-protein kinase N2	IC	125549	gi	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00047	PDGF signaling pathway	P01167	Ets	HUMAN|HGNC=3319|UniProtKB=Q99607	ETS-related transcription factor Elf-4	ISS	15298723	PubMed	PTHR11849:SF170	ETS-RELATED TRANSCRIPTION FACTOR ELF-4
P06664	Gonadotropin-releasing hormone receptor pathway	P06832	c-Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	RCA	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01211	ERK	RAT|RGD=628675|UniProtKB=Q9Z2A6	Mitogen-activated protein kinase 15	IDA	10514528	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00881	ROCK	RAT|RGD=620424|UniProtKB=Q63644	Rho-associated protein kinase 1	ISS	10779382	PubMed	PTHR22988:SF33	RHO-ASSOCIATED PROTEIN KINASE 1
P00009	Axon guidance mediated by netrin	P00357	Netrin	DANRE|ZFIN=ZDB-GENE-990415-169|UniProtKB=O42140	Netrin-1a	ISS	9427245	PubMed	PTHR10574:SF366	NETRIN-1A
P00034	Integrin signalling pathway	P00907	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00015	Circadian clock system	P00504	Per	CANLF|Ensembl=ENSCAFG00000016984|UniProtKB=E2R0I6	Uncharacterized protein	ISS	12782655	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00805	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00477	GSK3beta	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	IDA	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04397	p53 pathway by glucose deprivation	G04706	TSC2	PANTR|Ensembl=ENSPTRG00000031311|UniProtKB=H2R1U8	Uncharacterized protein	ISS	15249583	PubMed	PTHR10063:SF0	TUBERIN
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	MOUSE|MGI=MGI=95814|UniProtKB=Q60934	Glutamate receptor ionotropic, kainate 1	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	RCA	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00018	EGF receptor signaling pathway	P00539	14-3-3	MONDO|Ensembl=ENSMODG00000009856|UniProtKB=F6WA79	Uncharacterized protein	ISS	12480176	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00009	Axon guidance mediated by netrin	P00366	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	DROME|FlyBase=FBgn0001991|UniProtKB=Q24270	Voltage-dependent calcium channel type D subunit alpha-1	ISS	15737619	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P02738	De novo purine biosynthesis	P02908	Phosphoribosylamine glycine ligase	AQUAE|EnsemblGenome=aq_742|UniProtKB=O66949	Phosphoribosylamine--glycine ligase	ISS			PTHR43472:SF1	PHOSPHORIBOSYLAMINE--GLYCINE LIGASE
P00011	Blood coagulation	P00415	Plasmin	RAT|RGD=619893|UniProtKB=Q01177	Plasminogen	ISS	16758216	gi	PTHR24261:SF5	PLASMINOGEN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	DANRE|ZFIN=ZDB-GENE-030131-6206|UniProtKB=F1Q5K4	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF676	MYOSIN, HEAVY POLYPEPTIDE 2, FAST MUSCLE SPECIFIC
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00642	MEK1-2	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8440264	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IC	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	MONDO|Ensembl=ENSMODG00000015142|UniProtKB=F7CZL9	Uncharacterized protein (Fragment)	ISS	11055438	PubMed	PTHR10117:SF9	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 7
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	ARATH|TAIR=AT1G32270|UniProtKB=Q9C615	Putative syntaxin-24	IC			PTHR19957:SF38	T-SNARE DOMAIN-CONTAINING PROTEIN 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	RAT|RGD=70911|UniProtKB=P38444	Activin receptor type-2A	TAS	9395284	PubMed	PTHR23255:SF64	ACTIVIN RECEPTOR TYPE-2A
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00048	PI3 kinase pathway	P01192	p110	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01227	20S proteasome	BOVIN|Gene=PSMB7|UniProtKB=Q2TBP0	Proteasome subunit beta type-7	ISS	12859888	PubMed	PTHR11599:SF42	PROTEASOME SUBUNIT BETA TYPE-7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IDA	14526383	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	CAEEL|WormBase=WBGene00002363|UniProtKB=G5EGK8	Serine/threonine-protein phosphatase	ISS			PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	CANLF|Ensembl=ENSCAFG00000003821|UniProtKB=E2RT60	Integrin beta	ISS	3487386	PubMed	PTHR10082:SF28	INTEGRIN BETA-1
P00052	TGF-beta signaling pathway	P01289	I-Smads	RAT|RGD=69314|UniProtKB=O88406	Mothers against decapentaplegic homolog 7	IGI	9335505	PubMed	PTHR13703:SF27	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 7
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	XENTR|Xenbase=XB-GENE-982496|UniProtKB=F6Z8A1	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00012	Cadherin signaling pathway	P00474	Wnt	BRAFL|Gene=BRAFLDRAFT_104698|UniProtKB=C3XYW6	Protein Wnt (Fragment)	IDA	8717036	PubMed	PTHR12027:SF81	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	MACMU|Ensembl=ENSMMUG00000001304|UniProtKB=F7BNR8	Receptor protein serine/threonine kinase	ISS			PTHR23255:SF61	TGF-BETA RECEPTOR TYPE-1
P02729	Ascorbate degradation	P02852	L-xylulose-5-phosphate-3-epimerase	YEAST|SGD=S000003657|UniProtKB=P46969	Ribulose-phosphate 3-epimerase	ISS			PTHR11749:SF3	RIBULOSE-PHOSPHATE 3-EPIMERASE
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00048	PI3 kinase pathway	P01188	Gbetagamma	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	BOVIN|Ensembl=ENSBTAG00000013099|UniProtKB=Q3ZBY4	Fructose-bisphosphate aldolase	ISS	2350361	PubMed	PTHR11627:SF3	FRUCTOSE-BISPHOSPHATE ALDOLASE C
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DICDI|dictyBase=DDB_G0283907|UniProtKB=P34099	cAMP-dependent protein kinase catalytic subunit	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00048	PI3 kinase pathway	P01188	Gbetagamma	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00012	Cadherin signaling pathway	P00462	Casein kinase II	HUMAN|HGNC=2458|UniProtKB=Q8NEV1	Casein kinase II subunit alpha 3	ISS	10617630	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00004	Alzheimer disease-presenilin pathway	P00125	Ire-1 C-terminal fragment	MOUSE|MGI=MGI=1930134|UniProtKB=Q9EQY0	Serine/threonine-protein kinase/endoribonuclease IRE1	IDA	10619423	PubMed	PTHR13954:SF17	SERINE/THREONINE-PROTEIN KINASE/ENDORIBONUCLEASE IRE1
P00021	FGF signaling pathway	P00640	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00010	B cell activation	P00373	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IGI	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00563	Gab	PANTR|Ensembl=ENSPTRG00000004115|UniProtKB=H2R3E1	GRB2-associated binding protein 2	ISS	18105042	gi	PTHR12156:SF4	GRB2-ASSOCIATED-BINDING PROTEIN 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	RCA	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05913	Enkephalin release	P05972	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00642	MEK1-2	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02746	Heme biosynthesis	P02972	Ferrochelatase	ORYSJ|Gene=Os05g0361200|UniProtKB=Q0DIV0	Ferrochelatase-2, chloroplastic	ISS			PTHR11108:SF1	FERROCHELATASE, MITOCHONDRIAL
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	CHICK|Ensembl=ENSGALG00000027629|UniProtKB=Q5ZJ03	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00054	Toll receptor signaling pathway	P01367	MKK3	ORNAN|Ensembl=ENSOANG00000007732|UniProtKB=F6PXH5	Uncharacterized protein (Fragment)	ISS	97059154	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	PANTR|Ensembl=ENSPTRG00000006890|UniProtKB=H2Q943	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02746	Heme biosynthesis	P02983	Hydroxymethylbilane synthase	METJA|EnsemblGenome=MJ_0569|UniProtKB=Q57989	Probable porphobilinogen deaminase	ISS			PTHR11557:SF0	PORPHOBILINOGEN DEAMINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=8153|UniProtKB=P41143	Delta-type opioid receptor	IDA	11259498	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P02747	Histidine biosynthesis	P02992	Imidazol glycerol phosphate synthase	LEPIN|EnsemblGenome=LA_2506|UniProtKB=P59119	Imidazole glycerol phosphate synthase subunit HisF	ISS			PTHR21235:SF2	IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF
P05731	GABA-B receptor II signaling	P05752	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00805	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IDA	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	ARATH|TAIR=AT3G18040|UniProtKB=Q9LV37	Mitogen-activated protein kinase 9	TAS			PTHR24055:SF246	MITOGEN-ACTIVATED PROTEIN KINASE 15-RELATED
P00021	FGF signaling pathway	P00628	JNK1-3	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IGI	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00551	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01174	Rho	MACMU|Ensembl=ENSMMUG00000031000|UniProtKB=F6Y6A5	Uncharacterized protein	ISS			PTHR23176:SF3	PROTEIN PRR5-ARHGAP8-RELATED
P00005	Angiogenesis	P00243	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00049	Parkinson disease	P01238	14-3-3	NEUCR|EnsemblGenome=EFNCRG00000002359|UniProtKB=Q7RVK6	14-3-3 family protein 7	ISS	22057342	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00006	Apoptosis signaling pathway	P00260	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00475	Frizzled	CANLF|Ensembl=ENSCAFG00000013159|UniProtKB=E2RAF3	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF79	FRIZZLED-9
P04393	Ras Pathway	P04567	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00589	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04626	GADD45	MACMU|Ensembl=ENSMMUG00000003468|UniProtKB=F7EBI6	Growth arrest and DNA damage-inducible protein GADD45 beta	ISS	10097101	PubMed	PTHR10411:SF5	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 BETA
P02785	Valine biosynthesis	P03218	Dihydroxy isovalerate dehydratase	METAC|EnsemblGenome=MA_3373|UniProtKB=Q8TKM8	Dihydroxy-acid dehydratase 2	ISS			PTHR43661:SF3	DIHYDROXY-ACID DEHYDRATASE
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	BACSU|EnsemblGenome=BSU36900|UniProtKB=P39148	Serine hydroxymethyltransferase	ISS			PTHR11680:SF21	SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00060	Ubiquitin proteasome pathway	P01491	E2	CHICK|Ensembl=ENSGALG00000021213|UniProtKB=E1BZJ2	Uncharacterized protein	ISS			PTHR24068:SF36	UBIQUITIN-CONJUGATING ENZYME E2 D1
P00054	Toll receptor signaling pathway	P01368	MKK2	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MACMU|Ensembl=ENSMMUG00000016049|UniProtKB=Q95JG1	Gonadotropin-releasing hormone II receptor	IDA	1333052	PubMed	PTHR24241:SF116	GONADOTROPIN-RELEASING HORMONE II RECEPTOR-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	TAS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01292	RSmads	CAEBR|Gene=CBG06922|UniProtKB=A8X3D3	Dwarfin sma (Fragment)	ISS	9395284	PubMed	PTHR13703:SF40	PROTEIN MOTHERS AGAINST DPP
P00059	p53 pathway	P04630	PP2A	IXOSC|EnsemblGenome=ISCW014549|UniProtKB=B7QGY5	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00807	Actin	XENTR|Xenbase=XB-GENE-491618|UniProtKB=Q6P378	Actin, cytoplasmic 2	ISS	11889139	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00317	Fos	BOVIN|Ensembl=ENSBTAG00000004322|UniProtKB=O77628	Proto-oncogene c-Fos	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00045	Notch signaling pathway	P01113	Pen-2	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	9332390	PubMed	PTHR10202:SF13	PRESENILIN-2
P00059	p53 pathway	P04630	PP2A	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	88248000	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00223	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00048	PI3 kinase pathway	P01188	Gbetagamma	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01457	GBeta	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	IDA	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MOUSE|MGI=MGI=2155600|UniProtKB=Q91Z83	Myosin-7	IEP	89264452	PubMed	PTHR13140:SF344	MYOSIN-7
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=1351344|UniProtKB=Q68ED2	Metabotropic glutamate receptor 7	ISS	12351712	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00054	Toll receptor signaling pathway	P01354	NFkappaB	BOVIN|Ensembl=ENSBTAG00000013895|UniProtKB=A1XG22	NF-kappaB transcription factor p65 subunit	ISS	10049353	PubMed	PTHR24169:SF1	TRANSCRIPTION FACTOR P65
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05913	Enkephalin release	P05974	G-Protein (i)	DROME|FlyBase=FBgn0004623|UniProtKB=P29829	Guanine nucleotide-binding protein subunit beta-2	IC			PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00034	Integrin signalling pathway	P00920	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	IPI	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MOUSE|MGI=MGI=99673|UniProtKB=P84309	Adenylate cyclase type 5	ISS	1409703	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	CANLF|Gene=CCL2|UniProtKB=P52203	C-C motif chemokine 2	ISS			PTHR12015:SF98	C-C MOTIF CHEMOKINE 2
P00057	Wnt signaling pathway	P01443	Phospholipase C	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	IDA	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00050	Plasminogen activating cascade	P01250	MMP-13	MACMU|Ensembl=ENSMMUG00000004253|UniProtKB=F6YQ28	Uncharacterized protein	ISS	8207000	PubMed	PTHR10201:SF165	COLLAGENASE 3
P00049	Parkinson disease	P01211	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	DICDI|dictyBase=DDB_G0279407|UniProtKB=P02599	Calmodulin	ISS	3885394	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_127489|UniProtKB=C3XYC6	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00049	Parkinson disease	P01211	ERK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	IDA	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01451	Galpha	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00141	Membrane metalloprotease	RAT|RGD=620198|UniProtKB=Q10739	Matrix metalloproteinase-14	TAS	12834808	PubMed	PTHR10201:SF24	MATRIX METALLOPROTEINASE-14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DANRE|ZFIN=ZDB-GENE-050417-267|UniProtKB=F1QUN8	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF263	ACTIN
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000012036|UniProtKB=F7ALP1	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P02738	De novo purine biosynthesis	P02891	GDP kinase	RAT|RGD=619880|UniProtKB=Q9QXL7	Nucleoside diphosphate kinase 7	ISS			PTHR43109:SF2	NUCLEOSIDE DIPHOSPHATE KINASE 7
P00006	Apoptosis signaling pathway	P00310	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IDA	7937853	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	G06687	BMP7	MOUSE|MGI=MGI=103302|UniProtKB=P23359	Bone morphogenetic protein 7	RCA	9759503	PubMed	PTHR11848:SF135	BONE MORPHOGENETIC PROTEIN 7
P02738	De novo purine biosynthesis	P02897	GTP reductase	BACTN|EnsemblGenome=BT_1998|UniProtKB=Q8A688	Anaerobic ribonucleoside-triphosphate reductase	ISS			PTHR21075:SF0	ANAEROBIC RIBONUCLEOSIDE-TRIPHOSPHATE REDUCTASE
P00054	Toll receptor signaling pathway	P01375	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEEL|WormBase=WBGene00018620|UniProtKB=O44588	Uncharacterized protein	ISS	3045562	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P05913	Enkephalin release	P05972	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MACMU|Ensembl=ENSMMUG00000004886|UniProtKB=F7AGT9	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TAKRU|Ensembl=ENSTRUG00000004787|UniProtKB=P53480	Actin, alpha cardiac	ISS	11889126	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00006	Apoptosis signaling pathway	P00283	A1	PANTR|Ensembl=ENSPTRG00000007359|UniProtKB=H2R888	BCL2-related protein A1	ISS	11964303	PubMed	PTHR11256:SF10	BCL-2-RELATED PROTEIN A1
P00005	Angiogenesis	P00185	JAK1	PANTR|Ensembl=ENSPTRG00000000825|UniProtKB=H2PZ66	Tyrosine-protein kinase	ISS	11929133	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	TAKRU|Ensembl=ENSTRUG00000016472|UniProtKB=H2UYR6	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	HUMAN|HGNC=4545|UniProtKB=P43250	G protein-coupled receptor kinase 6	IDA	8288567	PubMed	PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IDA	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00008	Axon guidance mediated by Slit/Robo	P00352	DCC	PANTR|Ensembl=ENSPTRG00000010031|UniProtKB=H2QEJ8	Uncharacterized protein	ISS	12810718	PubMed	PTHR44146:SF3	NETRIN RECEPTOR DCC
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	DANRE|ZFIN=ZDB-GENE-040426-2150|UniProtKB=Q6NUX8	Rho-related GTP-binding protein RhoA-A	ISS	11973360	PubMed	PTHR24072:SF260	RHO-RELATED GTP-BINDING PROTEIN RHOA-A-RELATED
P00029	Huntington disease	P00790	beta-Tubulin	HUMAN|HGNC=30829|UniProtKB=Q9BVA1	Tubulin beta-2B chain	TAS	9454836	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P04397	p53 pathway by glucose deprivation	P04640	p53	MACMU|Ensembl=ENSMMUG00000016569|UniProtKB=F6VXE7	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00018	EGF receptor signaling pathway	P00565	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	3045562	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00059	p53 pathway	G01581	BAX	MOUSE|MGI=MGI=99702|UniProtKB=Q07813	Apoptosis regulator BAX	IGI	11099028	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P00057	Wnt signaling pathway	P01464	Pygo	HUMAN|HGNC=30256|UniProtKB=Q9Y3Y4	Pygopus homolog 1	IDA	11955446	PubMed	PTHR23194:SF3	PYGOPUS HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	MACMU|Ensembl=ENSMMUG00000016428|UniProtKB=F7GU00	Metabotropic glutamate receptor 1 isoform alpha	ISS	14614461	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	TAS	9332390	PubMed	PTHR10202:SF13	PRESENILIN-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	IC	3045562	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00010	B cell activation	P00385	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00645	Rac	ORYSJ|Gene=Os01g0229400|UniProtKB=Q9SSX0	Rac-like GTP-binding protein 1	IGI	10485927	PubMed	PTHR24072:SF154	SUBFAMILY NOT NAMED
P05730	Endogenous cannabinoid signaling	P05751	Galpha	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	RCA	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00059	p53 pathway	P04614	Cyclin B	DANRE|ZFIN=ZDB-GENE-000406-10|UniProtKB=Q7ZU21	Cyclin B1	ISS	93040208	PubMed	PTHR10177:SF193	G2/MITOTIC-SPECIFIC CYCLIN-B1
P00048	PI3 kinase pathway	P01192	p110	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	HUMAN|HGNC=362|UniProtKB=P54819	Adenylate kinase 2, mitochondrial	ISS			PTHR23359:SF117	ADENYLATE KINASE 2, MITOCHONDRIAL
P06664	Gonadotropin-releasing hormone receptor pathway	P06784	Paxillin	MOUSE|MGI=MGI=108295|UniProtKB=Q8VI36	Paxillin	RCA	7579684	PubMed	PTHR24216:SF11	PAXILLIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00029	Huntington disease	P00780	Microtubule	ORYSJ|EnsemblGenome=OS03G0661300|UniProtKB=Q76FS2	Tubulin beta-8 chain	IDA	9454836	PubMed	PTHR11588:SF246	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	TAKRU|Ensembl=ENSTRUG00000015213|UniProtKB=H2UPJ1	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF356	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00983	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	BOVIN|Ensembl=ENSBTAG00000010111|UniProtKB=F1MJS2	Uncharacterized protein	ISS	12356903	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00021	FGF signaling pathway	P00633	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	91232861	PubMed	PTHR24070:SF385	GTPASE HRAS
P02723	Adenine and hypoxanthine salvage pathway	P02808	Deoxyadenosine phosphorylase	THEMA|EnsemblGenome=TM_1596|UniProtKB=Q9X1T2	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000000365|UniProtKB=F6R9F4	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P02751	Lysine biosynthesis	P03007	Diaminopimelate decarboxylase	SYNY3|EnsemblGenome=BAA10831|UniProtKB=Q55484	Diaminopimelate decarboxylase	ISS			PTHR43727:SF2	DIAMINOPIMELATE DECARBOXYLASE 1, CHLOROPLASTIC-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P02721	ATP synthesis	P02796	F1 gamma	CHLRE|EnsemblGenome=CHLREDRAFT_134235|UniProtKB=A8HXL8	Chloroplast ATP synthase gamma chain	ISS	2904436	PubMed	PTHR11693:SF23	MYB-LIKE PROTEIN O
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	DROME|FlyBase=FBgn0024326|UniProtKB=O61444	MAP kinase kinase 4, isoform A	IC	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BRAFL|Gene=BRAFLDRAFT_220697|UniProtKB=C3ZSF0	Putative uncharacterized protein	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00053	T cell activation	P01322	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04398	p53 pathway feedback loops 2	P04661	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IGI	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01018	Glu1	DROME|FlyBase=FBgn0264000|UniProtKB=M9PHV5	Glutamate receptor IB, isoform B	ISS	8804111	PubMed	PTHR18966:SF270	GLUTAMATE RECEPTOR 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	PANTR|Ensembl=ENSPTRG00000001767|UniProtKB=G2HG81	Actin-related protein 2/3 complex subunit 5	ISS	9230079	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	MOUSE|MGI=MGI=95808|UniProtKB=P23818	Glutamate receptor 1	ISS	12941441	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00021	FGF signaling pathway	P00639	Shc	MOUSE|MGI=MGI=98296|UniProtKB=P98083	SHC-transforming protein 1	IGI	7798194	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	BOVIN|Ensembl=ENSBTAG00000019210|UniProtKB=F1MJV4	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00047	PDGF signaling pathway	P01150	PKC	CANAL|CGD=CAL0003231|UniProtKB=Q5ANK2	Protein kinase C	ISS	125549	gi	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00021	FGF signaling pathway	P00633	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00057	Wnt signaling pathway	P01457	GBeta	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00049	Parkinson disease	P01211	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04658	PTEN	ARATH|TAIR=AT3G19420|UniProtKB=Q9LT75	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN2A	ISS			PTHR12305:SF32	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE TPTE2-RELATED
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00012	Cadherin signaling pathway	P00470	F-actin	HUMAN|HGNC=144|UniProtKB=P63261	Actin, cytoplasmic 2	IC	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00036	Interleukin signaling pathway	P00983	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	TAS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04610	Cyclin E	RAT|RGD=2294|UniProtKB=P39949	G1/S-specific cyclin-E1	IDA	15705141	gi	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PANTR|Ensembl=ENSPTRG00000002086|UniProtKB=H2Q1A9	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00006	Apoptosis signaling pathway	P00274	JNK	CAEEL|WormBase=WBGene00008200|UniProtKB=Q9U3L3	Uncharacterized protein	ISS			PTHR24055:SF253	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01438	PP2A	MOUSE|MGI=MGI=1349475|UniProtKB=Q60996	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	IDA	8576224	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P00021	FGF signaling pathway	P00635	FRS2	CANLF|Ensembl=ENSCAFG00000000431|UniProtKB=E2QSI0	Uncharacterized protein	ISS	12571252	PubMed	PTHR21258:SF40	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2
P00005	Angiogenesis	P00219	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00029	Huntington disease	P00800	PolyQ Htt	CANLF|Ensembl=ENSCAFG00000014682|UniProtKB=F1P7Y7	Uncharacterized protein	ISS	9462744	PubMed	PTHR10170:SF10	HUNTINGTIN
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	DROME|FlyBase=FBgn0264000|UniProtKB=M9PHV5	Glutamate receptor IB, isoform B	IC	12941441	PubMed	PTHR18966:SF270	GLUTAMATE RECEPTOR 1-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	15470041	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00005	Angiogenesis	P00219	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	15528206	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00625	MKK3,6	HUMAN|HGNC=6843|UniProtKB=P46734	Dual specificity mitogen-activated protein kinase kinase 3	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P05918	p38 MAPK pathway	P06020	p38delta	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000011757|UniProtKB=Q9XT97	Presenilin-1	IDA	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CHICK|Ensembl=ENSGALG00000000168|UniProtKB=P49892	Adenosine receptor A1	IDA	11781138	PubMed	PTHR24246:SF1	ADENOSINE RECEPTOR A1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	HUMAN|HGNC=235|UniProtKB=Q8NFM4	Adenylate cyclase type 4	ISS	2491850	PubMed	PTHR11920:SF286	ADENYLATE CYCLASE TYPE 4
P00021	FGF signaling pathway	P00642	MEK1-2	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00139	E-cadherin transmembrane fragment	RAT|RGD=69279|UniProtKB=Q9R0T4	Cadherin-1	IDA	8120095	PubMed	PTHR24027:SF319	CADHERIN-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	IDA	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00059	p53 pathway	P01486	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00471	Cadherin	BOVIN|Ensembl=ENSBTAG00000021497|UniProtKB=F1MXP9	Uncharacterized protein	ISS	8120095	PubMed	PTHR43956:SF3	CADHERIN-23
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CHICK|Ensembl=ENSGALG00000007509|UniProtKB=F1NM72	Uncharacterized protein	ISS	87005246	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P05913	Enkephalin release	P05974	G-Protein (i)	RAT|RGD=69319|UniProtKB=P54313	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00021	FGF signaling pathway	P00643	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06831	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	RCA	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00021	FGF signaling pathway	P00644	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-040426-1693|UniProtKB=Q6P967	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00996	STAT	HUMAN|HGNC=11367|UniProtKB=P51692	Signal transducer and activator of transcription 5B	IC	8732682	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	CAEBR|Gene=CBG02059|UniProtKB=A8WRW6	Protein CBR-UNC-2 (Fragment)	ISS	14507926	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	RCA	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04392	P53 pathway feedback loops 1	P04539	p53	BOVIN|Ensembl=ENSBTAG00000015460|UniProtKB=F1MKA9	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	CHICK|Ensembl=ENSGALG00000021020|UniProtKB=F1NN71	Uncharacterized protein	IDA			PTHR24241:SF61	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00629	PP2A	ORYSJ|EnsemblGenome=OS06G0574500|UniProtKB=Q0DBD3	Serine/threonine-protein phosphatase PP2A-1 catalytic subunit	ISS			PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	SCHPO|PomBase=SPAC6F6.10c|UniProtKB=O14241	Actin-related protein 2/3 complex subunit 2	ISS			PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	HUMAN|HGNC=15906|UniProtKB=A7E2Y1	Myosin-7B	ISS	89264452	PubMed	PTHR13140:SF358	MYOSIN-7B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00001	Adrenaline and noradrenaline biosynthesis	P00068	amine translocator	RAT|RGD=621651|UniProtKB=Q64093	Sodium- and chloride-dependent transporter XTRP3	IC	12719981	PubMed	PTHR11616:SF44	SODIUM- AND CHLORIDE-DEPENDENT TRANSPORTER XTRP3
P02741	Flavin biosynthesis	P02935	GTP cyclohydrolase	LEPIN|EnsemblGenome=LA_1147|UniProtKB=Q8F701	Riboflavin biosynthesis protein RibBA	ISS			PTHR21327:SF32	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P05913	Enkephalin release	P05972	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00057	Wnt signaling pathway	P01451	Galpha	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	IDA	9009705	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00037	Ionotropic glutamate receptor pathway	P01023	CaMKII	TAKRU|Ensembl=ENSTRUG00000016081|UniProtKB=H2UVZ1	Uncharacterized protein	ISS	12888804	PubMed	PTHR43940:SF3	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT BETA
P00012	Cadherin signaling pathway	P00466	EGFR	RAT|RGD=2543|UniProtKB=G3V6K6	Receptor protein-tyrosine kinase	ISS	90258888	PubMed	PTHR24416:SF91	EPIDERMAL GROWTH FACTOR RECEPTOR
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00029	Huntington disease	P00807	Actin	MACMU|Ensembl=ENSMMUG00000001353|UniProtKB=F7D6T8	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00010	B cell activation	P00368	vav	MOUSE|MGI=MGI=1888518|UniProtKB=Q9R0C8	Guanine nucleotide exchange factor VAV3	IGI	14623913	PubMed	PTHR22826:SF97	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	IDA	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00036	Interleukin signaling pathway	P00966	mTOR	BOVIN|Ensembl=ENSBTAG00000015325|UniProtKB=E1BFB4	Uncharacterized protein	ISS	7518356	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IC	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=1758|UniProtKB=Q9H159	Cadherin-19	IDA	8120095	PubMed	PTHR24027:SF323	CADHERIN-19
P00029	Huntington disease	P00788	Calpain	RAT|RGD=620084|UniProtKB=Q8R4C0	Calpain-5	IDA	11675509	PubMed	PTHR10183:SF370	CALPAIN-5
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00047	PDGF signaling pathway	P01171	PLCgamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P06959	CCKR signaling map	P07230	4E-BP1	HUMAN|HGNC=3288|UniProtKB=Q13541	Eukaryotic translation initiation factor 4E-binding protein 1	RCA	9619831	PubMed	PTHR12669:SF14	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1
P05731	GABA-B receptor II signaling	P05755	Gbeta	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06798	PKCe/theta	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MACMU|Ensembl=ENSMMUG00000010266|UniProtKB=F6PV18	Uncharacterized protein	ISS	6309844	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	DANRE|ZFIN=ZDB-GENE-041114-26|UniProtKB=F1RE11	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02742	Tetrahydrofolate biosynthesis	P02941	Dihydroneopterin aldolase	DEIRA|EnsemblGenome=DR_0169|UniProtKB=Q9RXY5	7,8-dihydroneopterin aldolase	ISS			PTHR42844:SF1	DIHYDRONEOPTERIN ALDOLASE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000003236|UniProtKB=F7DNS6	Uncharacterized protein	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00029	Huntington disease	P00774	Dynein complex	ANOGA|EnsemblGenome=AGAP001335|UniProtKB=Q7PXC4	AGAP001335-PA	ISS	9454836	PubMed	PTHR11886:SF62	DYNEIN, LIGHT CHAIN, LC8-TYPE 2
P00034	Integrin signalling pathway	P00951	Jnk	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	IDA	10207617	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00001	Adrenaline and noradrenaline biosynthesis	P00070	VAT2	HUMAN|HGNC=10935|UniProtKB=Q05940	Synaptic vesicular amine transporter	IC	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DAPPU|EnsemblGenome=DAPPUDRAFT_228751|UniProtKB=E9HGF5	Cytoplasmatic actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00047	PDGF signaling pathway	P01151	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	HUMAN|HGNC=4593|UniProtKB=Q13255	Metabotropic glutamate receptor 1	ISS	14614461	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04397	p53 pathway by glucose deprivation	P04641	Akt	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	ISS	12655147	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05915	Opioid proenkephalin pathway	P05994	G-protein	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00021	FGF signaling pathway	P00646	RasGAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	IPI	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MOUSE|MGI=MGI=1339712|UniProtKB=P13542	Myosin-8	ISS	89264452	PubMed	PTHR13140:SF368	MYOSIN-8
P02721	ATP synthesis	P02791	F1 alpha	PANTR|Ensembl=ENSPTRG00000009991|UniProtKB=A5A6H5	ATP synthase subunit alpha, mitochondrial	ISS	2527557	PubMed	PTHR43089:SF4	ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL
P00018	EGF receptor signaling pathway	P00551	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	MOUSE|MGI=MGI=109284|UniProtKB=Q61144	Presenilin-2	TAS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	TAS	10207617	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	XENTR|Xenbase=XB-GENE-491618|UniProtKB=Q6P378	Actin, cytoplasmic 2	ISS	3487386	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00057	Wnt signaling pathway	P01450	Bcl9	BOVIN|Ensembl=ENSBTAG00000002422|UniProtKB=E1BPF3	Uncharacterized protein	ISS	11955446	PubMed	PTHR15185:SF5	B-CELL CLL/LYMPHOMA 9 PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00562	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04393	Ras Pathway	P04546	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00018	EGF receptor signaling pathway	P00564	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	20264070	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04393	Ras Pathway	P04541	p90RSK	MOUSE|MGI=MGI=104558|UniProtKB=P18653	Ribosomal protein S6 kinase alpha-1	IDA	15226426	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00018	EGF receptor signaling pathway	P00558	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00019	Endothelin signaling pathway	P00566	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	MACMU|Ensembl=ENSMMUG00000005530|UniProtKB=F7GFB1	Synaptotagmin I	ISS	SYT1_BOVIN	SPACC	PTHR10024:SF239	SYNAPTOTAGMIN-1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000007882|UniProtKB=G3X7Z2	Uncharacterized protein	ISS	8386525	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00025	Hedgehog signaling pathway	P00685	Smoothened	MACMU|Ensembl=ENSMMUG00000012110|UniProtKB=F7H8W1	Uncharacterized protein	ISS	942251	PubMed	PTHR11309:SF35	SMOOTHENED HOMOLOG
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	CHICK|Ensembl=ENSGALG00000012894|UniProtKB=P30372	Muscarinic acetylcholine receptor M2	ISS	12181435	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00049	Parkinson disease	P01212	p38 MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9836512	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00811	Arp2/3 complex	BOVIN|Gene=ARPC5|UniProtKB=Q3SYX9	Actin-related protein 2/3 complex subunit 5	ISS	12473693	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	RAT|RGD=1561867|UniProtKB=D4A670	Protein Lefty1	ISS	9759503	PubMed	PTHR11848:SF181	LEFT-RIGHT DETERMINATION FACTOR 1
P00012	Cadherin signaling pathway	P00470	F-actin	HUMAN|HGNC=145|UniProtKB=P63267	Actin, gamma-enteric smooth muscle	IC	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00004	Alzheimer disease-presenilin pathway	P00141	Membrane metalloprotease	HUMAN|HGNC=7160|UniProtKB=P50281	Matrix metalloproteinase-14	TAS	12834808	PubMed	PTHR10201:SF24	MATRIX METALLOPROTEINASE-14
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	PANTR|Ensembl=ENSPTRG00000006510|UniProtKB=H2Q8K1	Presenilin	ISS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P02768	Proline biosynthesis	P03112	Glutamate semialdehyde dehydrogenase	YEAST|SGD=S000005850|UniProtKB=P54885	Gamma-glutamyl phosphate reductase	ISS			PTHR11063:SF8	DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00632	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	TAS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	YEAST|SGD=S000005854|UniProtKB=P33328	Synaptobrevin homolog 2	IC			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MONDO|Ensembl=ENSMODG00000013079|UniProtKB=F7FB74	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00005	Angiogenesis	P00206	Wnt	ANOGA|EnsemblGenome=AGAP009734|UniProtKB=Q5TP56	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P04393	Ras Pathway	P04558	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	IDA	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	CHICK|Ensembl=ENSGALG00000006426|UniProtKB=E1BS97	Uncharacterized protein	ISS	10644687	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00021	FGF signaling pathway	P00641	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00023	General transcription regulation	P00666	TFIIE	CANLF|Ensembl=ENSCAFG00000011306|UniProtKB=E2R3P2	Uncharacterized protein	ISS	92065982	PubMed	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000003043|UniProtKB=P63212	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P05915	Opioid proenkephalin pathway	P05994	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00269	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	XENTR|Xenbase=XB-GENE-490883|UniProtKB=Q6NVA9	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00030	Hypoxia response via HIF activation	P00817	TOR	PANTR|Ensembl=ENSPTRG00000000142|UniProtKB=H2PY03	Uncharacterized protein	ISS	7518356	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01284	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000009939|UniProtKB=H2QED9	Cadherin 2, type 1, N-cadherin (Neuronal)	ISS	13678586	PubMed	PTHR24027:SF79	CADHERIN-2
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHICK|Ensembl=ENSGALG00000028749|UniProtKB=Q5ZMQ2	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00018	EGF receptor signaling pathway	P00562	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	12810719	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00010	B cell activation	P00383	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00021	FGF signaling pathway	P00633	Ras	BOVIN|Ensembl=ENSBTAG00000009778|UniProtKB=E1BMX0	Uncharacterized protein	ISS	3023884	PubMed	PTHR24070:SF186	GTPASE KRAS
P02753	Methionine biosynthesis	P03026	O-Succinyl homoserine lyase	THEMA|EnsemblGenome=TM_1270|UniProtKB=Q9X0Z7	Cystathionine gamma-synthase	ISS			PTHR11808:SF72	CYSTATHIONINE BETA LYASE
P00046	Oxidative stress response	P01129	JNK1/2	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	IC	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	DICDI|dictyBase=DDB_G0279413|UniProtKB=P05987	cAMP-dependent protein kinase regulatory subunit	IGI	92186968	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	ANOGA|EnsemblGenome=AGAP002219|UniProtKB=Q7QK91	AGAP002219-PA	ISS	10684567	PubMed	PTHR24070:SF385	GTPASE HRAS
P00039	Metabotropic glutamate receptor group III pathway	P01043	AC	MACMU|Ensembl=ENSMMUG00000010380|UniProtKB=F7D9M6	Uncharacterized protein	ISS	9874775	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00018	EGF receptor signaling pathway	P00554	Shc	MOUSE|MGI=MGI=98296|UniProtKB=P98083	SHC-transforming protein 1	IGI	95096035	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00045	Notch signaling pathway	P01120	NIcs	BOVIN|Ensembl=ENSBTAG00000007909|UniProtKB=F1MPE9	Uncharacterized protein	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00029	Huntington disease	P00794	Hippi	BOVIN|Ensembl=ENSBTAG00000005787|UniProtKB=Q5EA95	Intraflagellar transport protein 57 homolog	ISS	11889126	PubMed	PTHR16011:SF0	INTRAFLAGELLAR TRANSPORT PROTEIN 57 HOMOLOG
P00005	Angiogenesis	P00223	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02743	Formyltetrahydroformate biosynthesis	P02958	Dihydrofolate synthase	DEIRA|EnsemblGenome=DR_0340|UniProtKB=Q9RXH3	Folyl-polyglutamate synthetase	ISS			PTHR11136:SF0	DIHYDROFOLATE SYNTHETASE-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05918	p38 MAPK pathway	P06020	p38delta	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00018	EGF receptor signaling pathway	P00542	EGFR	RAT|RGD=2561|UniProtKB=P06494	Receptor tyrosine-protein kinase erbB-2	IGI	8393325	gi	PTHR24416:SF137	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2
P00036	Interleukin signaling pathway	P00964	p90RSK	ORNAN|Ensembl=ENSOANG00000010658|UniProtKB=F6V2V1	Uncharacterized protein	ISS	10558991	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	XENTR|Xenbase=XB-GENE-484032|UniProtKB=F6QWD3	Tyrosine-protein kinase receptor	ISS	249616	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	RCA	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00005	Angiogenesis	P00206	Wnt	BOVIN|Ensembl=ENSBTAG00000001668|UniProtKB=F1N6L8	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00059	p53 pathway	P04630	PP2A	PANTR|Ensembl=ENSPTRG00000017238|UniProtKB=H2QRH7	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P02721	ATP synthesis	P02798	Cyt C	TAKRU|Ensembl=ENSTRUG00000002170|UniProtKB=H2RXW2	Uncharacterized protein	ISS	4358609	PubMed	PTHR11961:SF12	CYTOCHROME C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	RAT|RGD=620593|UniProtKB=O54814	C-C chemokine receptor type 3	ISS			PTHR10489:SF649	C-C CHEMOKINE RECEPTOR TYPE 3
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MACMU|Ensembl=ENSMMUG00000010266|UniProtKB=F6PV18	Uncharacterized protein	ISS	6309844	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00047	PDGF signaling pathway	P01160	IP3 receptor	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00057	Wnt signaling pathway	P01435	SWI/SNF	HUMAN|HGNC=11107|UniProtKB=Q92925	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2	IDA	11532957	PubMed	PTHR13844:SF2	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D MEMBER 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	HUMAN|HGNC=6694|UniProtKB=P98164	Low-density lipoprotein receptor-related protein 2	IDA	11907044	PubMed	PTHR44025:SF5	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	IPI	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00010	B cell activation	P00367	NFAT	CANLF|Ensembl=ENSCAFG00000011625|UniProtKB=F1PDD9	Uncharacterized protein	ISS	12787506	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	TAKRU|Ensembl=ENSTRUG00000009259|UniProtKB=H2TF39	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_115291|UniProtKB=C3ZMR2	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF359	SUBFAMILY NOT NAMED
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT1G59580|UniProtKB=Q39022	Mitogen-activated protein kinase 2	IDA	11707292	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	MOUSE|MGI=MGI=109284|UniProtKB=Q61144	Presenilin-2	IDA	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MOUSE|MGI=MGI=1276116|UniProtKB=B2RWS6	Histone acetyltransferase p300	ISS	8413673	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00059	p53 pathway	P01486	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01312	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04395	Vasopressin synthesis	P04590	Vasopressin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P02768	Proline biosynthesis	P03114	Glutamyl kinase	SCHPO|PomBase=SPAC17H9.13c|UniProtKB=O13810	Probable glutamate 5-kinase	ISS			PTHR43654:SF3	GLUTAMATE 5-KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=101848|UniProtKB=P62881	Guanine nucleotide-binding protein subunit beta-5	IC	10051575	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00005	Angiogenesis	P00235	c-Fos	BOVIN|Ensembl=ENSBTAG00000004322|UniProtKB=O77628	Proto-oncogene c-Fos	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000012822|UniProtKB=F6PX40	Phosphoinositide phospholipase C	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P00023	General transcription regulation	P00669	TFIIEalpha	MACMU|Ensembl=ENSMMUG00000001596|UniProtKB=F7GV34	General transcription factor IIE subunit 1	ISS	189962	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	YEAST|SGD=S000000872|UniProtKB=P21524	Ribonucleoside-diphosphate reductase large chain 1	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00019	Endothelin signaling pathway	P00589	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00046	Oxidative stress response	P01131	MKP5	MOUSE|MGI=MGI=1351599|UniProtKB=Q9QYJ7	Dual specificity protein phosphatase 13 isoform B	ISS			PTHR10159:SF365	DUAL SPECIFICITY PROTEIN PHOSPHATASE 13 ISOFORM B
P00048	PI3 kinase pathway	P01179	PKB	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00809	Caspase 6	XENTR|Xenbase=XB-GENE-482797|UniProtKB=F6R1R1	Uncharacterized protein	ISS	11463840	PubMed	PTHR10454:SF164	CASPASE-6
P00047	PDGF signaling pathway	P01161	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06210	Activin beta signaling pathway	P06232	activinbeta full length	DROME|FlyBase=FBgn0024913|UniProtKB=O61643	Inhibin beta chain	IEA	9618266	PubMed	PTHR11848:SF133	INHIBIN BETA A CHAIN
P00029	Huntington disease	P00796	Kainate receptor	HUMAN|HGNC=4583|UniProtKB=Q16478	Glutamate receptor ionotropic, kainate 5	IDA	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00015	Circadian clock system	G01504	bmal1	MOUSE|MGI=MGI=1096381|UniProtKB=Q9WTL8	Aryl hydrocarbon receptor nuclear translocator-like protein 1	IDA	11163178	PubMed	PTHR23042:SF52	ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 1
P00023	General transcription regulation	P00668	TFIIB	ARATH|TAIR=AT4G10680|UniProtKB=O82494	Putative uncharacterized protein AT4g10680	ISS			PTHR11618:SF4	TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT
P00053	T cell activation	P01311	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02728	Arginine biosynthesis	P02847	N-actetylornithine deacetylase	AQUAE|EnsemblGenome=aq_547|UniProtKB=O66823	Succinyl-diaminopimelate desuccinylase	ISS			PTHR43808:SF3	ACETYLORNITHINE DEACETYLASE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01438	PP2A	SCHMA|EnsemblGenome=Smp_165490|UniProtKB=C1LZY9	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MOUSE|MGI=MGI=87904|UniProtKB=P60710	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00036	Interleukin signaling pathway	P00990	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00013	Cell cycle	P00484	Cyclin D	PANTR|Ensembl=ENSPTRG00000018164|UniProtKB=H2R7A8	Cyclin D3	ISS	12884287	PubMed	PTHR10177:SF65	G1/S-SPECIFIC CYCLIN-D3
P00021	FGF signaling pathway	P00642	MEK1-2	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00049	Parkinson disease	P01228	DAT	RAT|RGD=3715|UniProtKB=P23977	Sodium-dependent dopamine transporter	TAS	15135042	PubMed	PTHR11616:SF38	SODIUM-DEPENDENT DOPAMINE TRANSPORTER
P00047	PDGF signaling pathway	P01162	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00018	EGF receptor signaling pathway	P00562	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00053	T cell activation	P01297	MEKK	PANTR|Ensembl=ENSPTRG00000016891|UniProtKB=H2R5K3	Uncharacterized protein	RCA	8940199	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01026	KA	PANTR|Gene=GRIK4|UniProtKB=Q5IS46	Glutamate receptor ionotropic, kainate 4	ISS	11319238	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	TAKRU|Ensembl=ENSTRUG00000006307|UniProtKB=H2SSM1	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00019	Endothelin signaling pathway	P00570	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	10074940	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00920	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	RAT|RGD=621060|UniProtKB=O88777	Presenilin-2	TAS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	HUMAN|HGNC=667|UniProtKB=P61586	Transforming protein RhoA	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P02775	Salvage pyrimidine ribonucleotides	P03156	CDP kinase	SCHPO|PomBase=SPCC162.11c|UniProtKB=O74427	Uridine kinase	ISS			PTHR10285:SF123	URIDINE KINASE
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	IC	2372396	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00053	T cell activation	P01303	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00019	Endothelin signaling pathway	P00574	Big ET1-4	PANTR|Ensembl=ENSPTRG00000013684|UniProtKB=H2R2X8	Uncharacterized protein	ISS	10884419	PubMed	PTHR13874:SF11	ENDOTHELIN-3
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	PANTR|Gene=DRD2|UniProtKB=P60026	D(2) dopamine receptor	ISS	11861492	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00034	Integrin signalling pathway	P00912	Arp2/3	CANLF|Ensembl=ENSCAFG00000015094|UniProtKB=F1PT97	Uncharacterized protein	ISS	12473693	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P04393	Ras Pathway	P04570	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00005	Angiogenesis	P00255	Notch	MOUSE|MGI=MGI=97364|UniProtKB=O35516	Neurogenic locus notch homolog protein 2	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	PANTR|Ensembl=ENSPTRG00000009000|UniProtKB=H2R9L7	C-C motif chemokine	ISS			PTHR12015:SF78	C-C MOTIF CHEMOKINE 7
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000022886|UniProtKB=E1BE29	Uncharacterized protein	ISS	15226293	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00029	Huntington disease	P00788	Calpain	RAT|RGD=1307341|UniProtKB=D3ZJZ8	Protein Capn12	ISS	11675509	PubMed	PTHR10183:SF280	CALPAIN-12
P02746	Heme biosynthesis	P02975	Uroporphyrinogen decarboxylase	PANTR|Ensembl=ENSPTRG00000000668|UniProtKB=H2PYW8	Uroporphyrinogen decarboxylase	ISS			PTHR21091:SF2	UROPORPHYRINOGEN DECARBOXYLASE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00029	Huntington disease	G01531	BDNF	HUMAN|HGNC=1033|UniProtKB=P23560	Brain-derived neurotrophic factor	ISS	11724916	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P05913	Enkephalin release	P05974	G-Protein (i)	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P06959	CCKR signaling map	P07100	Dynamin	HUMAN|HGNC=2972|UniProtKB=Q05193	Dynamin-1	RCA	16079138	PubMed	PTHR11566:SF32	DYNAMIN-1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04392	P53 pathway feedback loops 1	G04686	p73	MACMU|Ensembl=ENSMMUG00000016569|UniProtKB=F6VXE7	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00053	T cell activation	P01305	Calmodulin	MACMU|Ensembl=ENSMMUG00000017921|UniProtKB=F7EDG8	Uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF335	CALMODULIN, STRIATED MUSCLE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHICK|Ensembl=ENSGALG00000011086|UniProtKB=P68139	Actin, alpha skeletal muscle	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P02784	Tyrosine biosynthesis	P03214	Prephenate dehydrogenase	RHOBA|EnsemblGenome=RB5392|UniProtKB=Q7URX9	Prephenate dehydrogenase	ISS			PTHR21363:SF0	PREPHENATE DEHYDROGENASE  NADP +
P00034	Integrin signalling pathway	P00944	Actin	MONDO|Ensembl=ENSMODG00000002647|UniProtKB=F7DIB7	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00047	PDGF signaling pathway	P01142	p90RSK	RAT|RGD=1305144|UniProtKB=D4AE24	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00049	Parkinson disease	P01235	Fyn kinase	MACMU|Ensembl=ENSMMUG00000017017|UniProtKB=F7FVL2	Tyrosine-protein kinase	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00029	Huntington disease	P00796	Kainate receptor	CHICK|Ensembl=ENSGALG00000015835|UniProtKB=F1NZT2	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00048	PI3 kinase pathway	P01182	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02763	Peptidoglycan biosynthesis	P03084	UDP-N-acetylmuramoylalanyl-D-glutamate 2,6-diaminopimelate ligase	FUSNN|EnsemblGenome=FN1225|UniProtKB=Q8R635	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase	ISS			PTHR23135:SF4	UDP-N-ACETYLMUAMOYLALANYL-D-GLUTAMATE-2,6-DIAMINOPIMELATE LIGASE-RELATED
P00004	Alzheimer disease-presenilin pathway	P00117	E-cadherin C-terminal fragment	HUMAN|HGNC=1748|UniProtKB=P12830	Cadherin-1	IDA	11953314	PubMed	PTHR24027:SF319	CADHERIN-1
P00053	T cell activation	P01300	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00807	Actin	DROME|FlyBase=FBgn0000045|UniProtKB=P02574	Actin, larval muscle	IDA	14684598	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00018	EGF receptor signaling pathway	P00547	PP2A	PANTR|Ensembl=ENSPTRG00000001958|UniProtKB=H2Q137	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00054	Toll receptor signaling pathway	P01368	MKK2	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00010	B cell activation	P00379	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00005	Angiogenesis	P00221	JNK1	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04397	p53 pathway by glucose deprivation	P04636	S6K	XENTR|Xenbase=XB-GENE-482409|UniProtKB=F6UK84	Uncharacterized protein (Fragment)	ISS	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00057	Wnt signaling pathway	P01428	Frizzled	MOUSE|MGI=MGI=108474|UniProtKB=Q61089	Frizzled-6	IDA	11212302	PubMed	PTHR11309:SF75	FRIZZLED-6
P00034	Integrin signalling pathway	P00931	Integrin beta	MOUSE|MGI=MGI=96616|UniProtKB=P26011	Integrin beta-7	IDA	3487386	PubMed	PTHR10082:SF36	INTEGRIN BETA-7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00924	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	TAS	9836512	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01428	Frizzled	HUMAN|HGNC=4045|UniProtKB=O75084	Frizzled-7	IDA	8717036	PubMed	PTHR11309:SF31	FRIZZLED-7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=3346|UniProtKB=P10688	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	TAS			PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00056	VEGF signaling pathway	P01408	Akt/PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	HUMAN|HGNC=6091|UniProtKB=P06213	Insulin receptor	ISS	11182407	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00047	PDGF signaling pathway	P01154	Ras	BOVIN|Ensembl=ENSBTAG00000009778|UniProtKB=E1BMX0	Uncharacterized protein	ISS	99084794	PubMed	PTHR24070:SF186	GTPASE KRAS
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000022548|UniProtKB=F6Y9J9	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	HUMAN|HGNC=5289|UniProtKB=P28221	5-hydroxytryptamine receptor 1D	IEA	12441358	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00036	Interleukin signaling pathway	P00996	STAT	CANLF|Ensembl=ENSCAFG00000015346|UniProtKB=E2RE22	Signal transducer and activator of transcription	ISS	95188889	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	ORNAN|Ensembl=ENSOANG00000000979|UniProtKB=F6XKQ2	Glutamine synthetase	ISS			PTHR20852:SF45	GLUTAMINE SYNTHETASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=1766|UniProtKB=Q9ULB5	Cadherin-7	IDA	8120095	PubMed	PTHR24027:SF91	CADHERIN-7
P00034	Integrin signalling pathway	P00941	Integrin alpha	PANTR|Ensembl=ENSPTRG00000012700|UniProtKB=H2QJ29	Integrin, alpha 4 (Antigen CD49D, alpha 4 subunit of VLA-4 receptor)	ISS	3487386	PubMed	PTHR23220:SF78	INTEGRIN ALPHA-4
P00018	EGF receptor signaling pathway	P00564	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00029	Huntington disease	G01531	BDNF	PANTR|Ensembl=ENSPTRG00000028696|UniProtKB=Q5IS78	Brain-derived neurotrophic factor	ISS	12117585	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00019	Endothelin signaling pathway	P00583	cPLA2	MACMU|Ensembl=ENSMMUG00000021423|UniProtKB=F7EEZ1	Phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04393	Ras Pathway	P04544	Grb2	DANRE|ZFIN=ZDB-GENE-040426-1975|UniProtKB=Q6PC73	Growth factor receptor-bound protein 2	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00049	Parkinson disease	P01236	Casein kinase II	TRYB2|Gene=Tb09.211.4890|UniProtKB=Q38D21	Casein kinase II, putative	ISS	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00005	Angiogenesis	P00249	PAK	CANLF|Ensembl=ENSCAFG00000004956|UniProtKB=E2REH3	Uncharacterized protein	ISS	14580336	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00018	EGF receptor signaling pathway	P00552	Ras	DICDI|dictyBase=DDB_G0293434|UniProtKB=P15064	Ras-like protein rasG	IGI	7997267	PubMed	PTHR24070:SF282	RAS GTPASE-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	PANTR|Ensembl=ENSPTRG00000022187|UniProtKB=Q7YQL4	Serine/threonine-protein kinase PAK 3	ISS	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00052	TGF-beta signaling pathway	P01275	P38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01160	IP3 receptor	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01095	beta	BOVIN|Ensembl=ENSBTAG00000007517|UniProtKB=F1MUN1	Uncharacterized protein	ISS	15155845	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	PANTR|Ensembl=ENSPTRG00000008746|UniProtKB=H2QC84	Myosin, heavy chain 10, non-muscle	ISS	89264452	PubMed	PTHR13140:SF328	MYOSIN-10
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00046	Oxidative stress response	P01137	MNK1/2	RAT|RGD=1305728|UniProtKB=Q5U2N4	MAP kinase-interacting serine/threonine-protein kinase 2	ISS	11463832	PubMed	PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04572	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014262|UniProtKB=F7BYS8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	RAT|RGD=628852|UniProtKB=Q02294	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	14507926	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	CAEEL|WormBase=WBGene00010038|UniProtKB=P34443	GTP-binding protein Rheb homolog 1	ISS			PTHR24070:SF226	GTP-BINDING PROTEIN RHEB HOMOLOG
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	HUMAN|HGNC=232|UniProtKB=Q08828	Adenylate cyclase type 1	ISS	89298382	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P00047	PDGF signaling pathway	P01171	PLCgamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	MACMU|Ensembl=ENSMMUG00000010173|UniProtKB=F7AGU8	Presenilin	ISS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00036	Interleukin signaling pathway	P00994	FKHRL1	MOUSE|MGI=MGI=1890081|UniProtKB=Q9WVH4	Forkhead box protein O3	IPI	14775847	gi	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P04393	Ras Pathway	P04570	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00287	TNFR2	RAT|RGD=621238|UniProtKB=Q80WY6	Tumor necrosis factor receptor superfamily member 1B	ISS			PTHR23097:SF120	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1B
P02738	De novo purine biosynthesis	P02892	5-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase	ARATH|TAIR=AT4G18440|UniProtKB=Q8RY94	Adenylosuccinate lyase	ISS			PTHR43411:SF1	ADENYLOSUCCINATE LYASE
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	PANTR|Ensembl=ENSPTRG00000009322|UniProtKB=H2REI3	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF84	PROTEIN WNT-9B
P06664	Gonadotropin-releasing hormone receptor pathway	P06772	Tubulin	MOUSE|MGI=MGI=1095409|UniProtKB=P68373	Tubulin alpha-1C chain	RCA			PTHR11588:SF64	TUBULIN ALPHA-1C CHAIN
P00024	Glycolysis	P00679	Aldolase	HUMAN|HGNC=414|UniProtKB=P04075	Fructose-bisphosphate aldolase A	ISS	4812352	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00048	PI3 kinase pathway	P01177	P110ACT	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05730	Endogenous cannabinoid signaling	P05746	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00005	Angiogenesis	P00223	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	RAT|RGD=2500|UniProtKB=Q920D2	Dihydrofolate reductase	ISS			PTHR22778:SF16	DIHYDROFOLATE REDUCTASE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00203	Erk	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00626	Spry	RAT|RGD=1311472|UniProtKB=Q5HZA2	Protein Spry2	ISS	12815057	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANAL|CGD=CAL0003231|UniProtKB=Q5ANK2	Protein kinase C	TAS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00005	Angiogenesis	P00227	PLA2	ORNAN|Ensembl=ENSOANG00000001027|UniProtKB=F6QDY0	Phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	HUMAN|HGNC=11441|UniProtKB=O43752	Syntaxin-6	ISS	10839363	PubMed	PTHR19957:SF104	SYNTAXIN-6
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MONDO|Ensembl=ENSMODG00000000771|UniProtKB=F6SSS3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05731	GABA-B receptor II signaling	P05754	Ggamma	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00038	JAK/STAT signaling pathway	P01027	STAT	MONDO|Ensembl=ENSMODG00000014816|UniProtKB=F7CHH2	Signal transducer and activator of transcription	ISS	8732682	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	NAS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00045	Notch signaling pathway	P01110	Presenilin	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	ISS	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P05913	Enkephalin release	P05974	G-Protein (i)	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	IC	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01435	SWI/SNF	PANTR|Ensembl=ENSPTRG00000022902|UniProtKB=H2R455	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	ISS	11532957	PubMed	PTHR13711:SF206	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY E MEMBER 1
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00627	ERK1-2	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	ARATH|TAIR=AT4G34460|UniProtKB=P49177	Guanine nucleotide-binding protein subunit beta	ISS	9754712	PubMed	PTHR19850:SF48	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P02734	Chorismate biosynthesis	P02871	2-Deoxy-7-phosphoheptulonate synthase	NEUCR|EnsemblGenome=EFNCRG00000005541|UniProtKB=Q7S715	Phospho-2-dehydro-3-deoxyheptonate aldolase	ISS			PTHR21225:SF8	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00947	Laminin	RAT|RGD=621052|UniProtKB=F1MAA7	Protein Lamc1	ISS	2538453	PubMed	PTHR10574:SF270	LAMININ SUBUNIT GAMMA-1
P00018	EGF receptor signaling pathway	P00562	p38	CAEEL|WormBase=WBGene00004055|UniProtKB=Q17446	Mitogen-activated protein kinase pmk-1	IGI	11707292	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=101948|UniProtKB=P48615	Protein Wnt-11	IDA	11266476	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00049	Parkinson disease	P01219	SAPK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	NAS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00047	PDGF signaling pathway	P01175	Shc	RAT|RGD=69348|UniProtKB=O70143	SHC-transforming protein 3	ISS	98175964	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P00052	TGF-beta signaling pathway	P01275	P38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	11535291	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	IDA	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00052	TGF-beta signaling pathway	P01284	JNK	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	TAS	7600581	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04395	Vasopressin synthesis	P04597	Signal Peptide	BOVIN|Ensembl=ENSBTAG00000008026|UniProtKB=P01175	Oxytocin-neurophysin 1	ISS	3768139	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00053	T cell activation	P01331	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	MOUSE|MGI=MGI=109482|UniProtKB=P97445	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	14624853	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	DROME|FlyBase=FBgn0010399|UniProtKB=Q24418	Glutamate [NMDA] receptor subunit 1	IC	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00034	Integrin signalling pathway	P00947	Laminin	MACMU|Ensembl=ENSMMUG00000004321|UniProtKB=F6ZDE9	Uncharacterized protein	ISS	2538453	PubMed	PTHR10574:SF285	LAMININ SUBUNIT ALPHA-3
P00015	Circadian clock system	P00505	Cry	CANLF|Ensembl=ENSCAFG00000009379|UniProtKB=F1PNC9	Uncharacterized protein	ISS	10217146	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00005	Angiogenesis	P00190	RasGAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	2574500	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	ISS	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P02751	Lysine biosynthesis	P03009	Aspartokinase	NEUCR|EnsemblGenome=EFNCRG00000003525|UniProtKB=Q7RZC2	Homoserine dehydrogenase	ISS			PTHR43070:SF3	HOMOSERINE DEHYDROGENASE
P00021	FGF signaling pathway	P00641	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	PANTR|Ensembl=ENSPTRG00000005793|UniProtKB=H2REV2	Uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF139	CASEIN KINASE I ISOFORM ALPHA-LIKE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00010	B cell activation	P00391	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	MOUSE|MGI=MGI=97356|UniProtKB=Q01768	Nucleoside diphosphate kinase B	ISS			PTHR11349:SF57	NUCLEOSIDE DIPHOSPHATE KINASE B
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00029	Huntington disease	P00780	Microtubule	CHICK|Ensembl=ENSGALG00000026802|UniProtKB=G1K338	Uncharacterized protein	IDA	12932731	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P00023	General transcription regulation	P00670	TBP	ARATH|TAIR=AT1G04950|UniProtKB=Q9MAU3	Transcription initiation factor TFIID subunit 6	ISS			PTHR10221:SF13	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	HUMAN|HGNC=17780|UniProtKB=Q562R1	Beta-actin-like protein 2	IC	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00007	Axon guidance mediated by semaphorins	P00331	PAK	CHICK|Ensembl=ENSGALG00000000681|UniProtKB=E1C3P6	Uncharacterized protein	ISS	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	AQUAE|EnsemblGenome=aq_301|UniProtKB=O66648	Glutamine--fructose-6-phosphate aminotransferase [isomerizing]	ISS			PTHR10937:SF0	GH12731P-RELATED
P00029	Huntington disease	P00790	beta-Tubulin	BATDJ|Gene=BATDEDRAFT_15405|UniProtKB=F4NUL6	Alpha-Beta tubulin	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CIOIN|Ensembl=ENSCING00000007153|UniProtKB=L7N0T1	Uncharacterized protein	ISS			PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00010	B cell activation	P00391	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MONDO|Ensembl=ENSMODG00000001807|UniProtKB=F6Y7R9	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00029	Huntington disease	P00775	Rac	MACMU|Ensembl=ENSMMUG00000003957|UniProtKB=F6ZFI9	Rho-related GTP-binding protein RhoG	ISS	4757952	gi	PTHR24072:SF158	RHO-RELATED GTP-BINDING PROTEIN RHOG
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00006	Apoptosis signaling pathway	P00318	PKCs	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04398	p53 pathway feedback loops 2	P04665	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00049	Parkinson disease	P01234	GRK	PANTR|Ensembl=ENSPTRG00000003946|UniProtKB=H2Q482	Protein-serine/threonine kinase	ISS	10852916	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	MONDO|Ensembl=ENSMODG00000015456|UniProtKB=F6S406	Uncharacterized protein	ISS	1638632	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P05913	Enkephalin release	P05977	G-Protein (s)	BOVIN|Ensembl=ENSBTAG00000002125|UniProtKB=F1N461	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P02740	De novo pyrimidine ribonucleotides biosythesis	P02922	Orotate phosphoribosyltransferase	NEUCR|EnsemblGenome=EFNCRG00000004984|UniProtKB=Q7RVF7	Orotate phosphoribosyltransferase	ISS			PTHR19278:SF9	URIDINE 5'-MONOPHOSPHATE SYNTHASE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_94959|UniProtKB=C3XYC4	Putative uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00005	Angiogenesis	P00238	Ras	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	ISS	12104050	PubMed	PTHR24070:SF189	GTPASE NRAS
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00010	B cell activation	P00384	p38	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	RCA			PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00018	EGF receptor signaling pathway	P00552	Ras	PANTR|Ensembl=ENSPTRG00000034469|UniProtKB=H2Q2V0	Uncharacterized protein	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=1921982|UniProtKB=Q9D3G5	Syntaxin-11	ISS	11067767	PubMed	PTHR19957:SF30	SYNTAXIN-11
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	DROME|FlyBase=FBgn0004360|UniProtKB=P28465	Protein Wnt-2	TAS	11266476	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00047	PDGF signaling pathway	P01159	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	FUSNN|EnsemblGenome=FN1605|UniProtKB=P58793	Adenylosuccinate synthetase	IEP	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	15313841	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00001	Adrenaline and noradrenaline biosynthesis	P00061	PNMT	PANTR|Ensembl=ENSPTRG00000009098|UniProtKB=H2QCU9	Uncharacterized protein	ISS	82182968	PubMed	PTHR10867:SF18	PHENYLETHANOLAMINE N-METHYLTRANSFERASE
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00034	Integrin signalling pathway	P00922	Collagen	MACMU|Ensembl=ENSMMUG00000004103|UniProtKB=F6Z5V7	Uncharacterized protein	ISS	10778855	PubMed	PTHR24023:SF42	COLLAGEN ALPHA-1 XI  CHAIN
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01417	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01454	betaTrCP	MOUSE|MGI=MGI=2144023|UniProtKB=Q5SRY7	F-box/WD repeat-containing protein 11	IDA	12628165	PubMed	PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05934	ELK1	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	14670631	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00059	p53 pathway	P01486	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00056	VEGF signaling pathway	P01417	Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	ISS	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00030	Hypoxia response via HIF activation	P00823	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00058	mRNA splicing	P01473	U6	MONDO|Ensembl=ENSMODG00000018774|UniProtKB=F7ADZ9	Uncharacterized protein	ISS	9328476	PubMed	PTHR14212:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	TAS	12471242	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	TAS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	ORYSJ|EnsemblGenome=OS07G0492000|UniProtKB=Q07661	Nucleoside diphosphate kinase 1	ISS			PTHR11349:SF66	SUBFAMILY NOT NAMED
P05918	p38 MAPK pathway	P06027	CREB	BOVIN|Gene=CREB1|UniProtKB=P27925	Cyclic AMP-responsive element-binding protein 1	ISS	11390664	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00057	Wnt signaling pathway	P01443	Phospholipase C	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00006	Apoptosis signaling pathway	P00322	Cytochrome C	MACMU|Ensembl=ENSMMUG00000029549|UniProtKB=F7G769	Uncharacterized protein	ISS	4954366	PubMed	PTHR11961:SF15	CYTOCHROME C
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	BOVIN|Ensembl=ENSBTAG00000002215|UniProtKB=Q08DQ2	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2	ISS			PTHR10937:SF10	GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE  ISOMERIZING  2
P00010	B cell activation	P00402	Jnk	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	RCA	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	BOVIN|Ensembl=ENSBTAG00000009778|UniProtKB=E1BMX0	Uncharacterized protein	ISS	99084794	PubMed	PTHR24070:SF186	GTPASE KRAS
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IGI	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IDA	8132661	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00053	T cell activation	P01322	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00045	Notch signaling pathway	P01119	NIct	BOVIN|Ensembl=ENSBTAG00000007909|UniProtKB=F1MPE9	Uncharacterized protein	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00007	Axon guidance mediated by semaphorins	P00340	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	8649368	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04393	Ras Pathway	P04556	Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	IDA	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	CHICK|Ensembl=ENSGALG00000009320|UniProtKB=Q4JIM4	Presenilin-1	TAS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=17175|UniProtKB=Q9P212	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	10934033	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	ARATH|TAIR=AT2G30910|UniProtKB=O80856	Actin-related protein 2/3 complex subunit 1A	ISS	12932731	PubMed	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g234494|UniProtKB=A7RU31	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00005	Angiogenesis	P00208	MEKK1	BOVIN|Ensembl=ENSBTAG00000013790|UniProtKB=E1B847	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04393	Ras Pathway	P04560	AP1	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	IDA	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00004	Alzheimer disease-presenilin pathway	P00127	APP	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00012	Cadherin signaling pathway	P00470	F-actin	CHLRE|EnsemblGenome=CHLREDRAFT_24392|UniProtKB=A8JAV1	Actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00053	T cell activation	P01332	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IDA	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04393	Ras Pathway	P04567	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00004	Alzheimer disease-presenilin pathway	P00114	actin	XENTR|Xenbase=XB-GENE-488998|UniProtKB=Q5BL41	Actin-related protein 2	ISS	11889126	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00048	PI3 kinase pathway	P01179	PKB	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01230	Src kinase	MOUSE|MGI=MGI=88537|UniProtKB=P41241	Tyrosine-protein kinase CSK	IDA	7687537	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1170702	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00780	Microtubule	CHICK|Ensembl=ENSGALG00000007447|UniProtKB=P09207	Tubulin beta-6 chain	IDA	9454836	PubMed	PTHR11588:SF112	TUBULIN BETA-1 CHAIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00034	Integrin signalling pathway	P00912	Arp2/3	MONDO|Ensembl=ENSMODG00000001303|UniProtKB=F7BZM9	Uncharacterized protein (Fragment)	ISS	12932731	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00010	B cell activation	P00391	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00047	PDGF signaling pathway	P01174	Rho	MACMU|Ensembl=ENSMMUG00000016346|UniProtKB=F7GRE8	Rho GTPase-activating protein 5 isoform a	ISS			PTHR15377:SF4	RHO GTPASE-ACTIVATING PROTEIN 5
P00010	B cell activation	P00379	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00047	PDGF signaling pathway	P01161	Raf	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00057	Wnt signaling pathway	P01465	Ggamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00020	FAS signaling pathway	P00600	PARP	MOUSE|MGI=MGI=1891258|UniProtKB=Q3ULW8	Poly [ADP-ribose] polymerase	TAS	12101391	PubMed	PTHR10459:SF66	POLY  ADP-RIBOSE  POLYMERASE 3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	HUMAN|HGNC=132|UniProtKB=P60709	Actin, cytoplasmic 1	IDA	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00048	PI3 kinase pathway	P01187	IR	HUMAN|HGNC=6091|UniProtKB=P06213	Insulin receptor	ISS	14500580	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05916	Opioid prodynorphin pathway	P06002	G-protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IGI	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00005	Angiogenesis	P00205	GAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	2574500	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00034	Integrin signalling pathway	P00922	Collagen	PANTR|Ensembl=ENSPTRG00000006601|UniProtKB=H2R6B8	Collagen, type V, alpha 2	ISS	10778855	PubMed	PTHR24023:SF539	COLLAGEN ALPHA-2 V  CHAIN
P04392	P53 pathway feedback loops 1	G04682	MDM-2	MACMU|Ensembl=ENSMMUG00000014193|UniProtKB=F7AKR9	Uncharacterized protein	ISS	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00047	PDGF signaling pathway	P01143	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00021	FGF signaling pathway	P00644	p38	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	IGI	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00005	Angiogenesis	P00243	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00206	Wnt	HUMAN|HGNC=12775|UniProtKB=O00744	Protein Wnt-10b	IEP	12549854	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8661|UniProtKB=Q9HC56	Protocadherin-9	IDA	8120095	PubMed	PTHR43912:SF5	PROTOCADHERIN-9
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00057	Wnt signaling pathway	P01465	Ggamma	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	CHICK|Ensembl=ENSGALG00000009320|UniProtKB=Q4JIM4	Presenilin-1	IDA	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	CHLRE|EnsemblGenome=CHLREDRAFT_130559|UniProtKB=Q8S4W5	Qc-SNARE protein, Tlg1/Syntaxin 6-family	ISS			PTHR19957:SF124	HL02043P
P00036	Interleukin signaling pathway	P00996	STAT	PANTR|Ensembl=ENSPTRG00000009200|UniProtKB=H2QD20	Signal transducer and activator of transcription	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00019	Endothelin signaling pathway	P00583	cPLA2	PANTR|Ensembl=ENSPTRG00000001787|UniProtKB=H2Q0T0	Phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00057	Wnt signaling pathway	P01451	Galpha	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	IDA	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	CANLF|Ensembl=ENSCAFG00000001738|UniProtKB=E2RDG9	Uncharacterized protein	ISS	11431030	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04543	MEKK1/4	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	IDA	12168099	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04566	Stat 1/3	HUMAN|HGNC=11362|UniProtKB=P42224	Signal transducer and activator of transcription 1-alpha/beta	IDA	15825084	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00020	FAS signaling pathway	P00615	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00036	Interleukin signaling pathway	P00996	STAT	PANTR|Ensembl=ENSPTRG00000009200|UniProtKB=H2QD20	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00030	Hypoxia response via HIF activation	P00819	AKT	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	IC	12655147	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05760	AC	MACMU|Ensembl=ENSMMUG00000010440|UniProtKB=F7CRV6	Uncharacterized protein	ISS	8163524	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00049	Parkinson disease	P01242	Casein kinase I	LEIMA|EnsemblGenome=LmjF.04.1210|UniProtKB=O96999	Putative casein kinase I	IDA	11437445	PubMed	PTHR11909:SF292	SUBFAMILY NOT NAMED
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=1338042|UniProtKB=E9PXQ7	Protein Pcdh10	IDA	8120095	PubMed	PTHR24028:SF0	PROTOCADHERIN-10
P00010	B cell activation	P00385	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	IDA	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00030	Hypoxia response via HIF activation	P00819	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00628	JNK1-3	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IGI	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00048	PI3 kinase pathway	P01177	P110ACT	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	IC	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	CANLF|Ensembl=ENSCAFG00000000550|UniProtKB=F6V7Y8	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF196	REGULATOR OF G-PROTEIN SIGNALING 17
P00034	Integrin signalling pathway	P00929	C3G	MACMU|Ensembl=ENSMMUG00000006479|UniProtKB=F6XRQ1	Uncharacterized protein	ISS	10777617	PubMed	PTHR23113:SF224	RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1
P05731	GABA-B receptor II signaling	P05754	Ggamma	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	RCA	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P06664	Gonadotropin-releasing hormone receptor pathway	P06834	MAP3Ks	MOUSE|MGI=MGI=1346876|UniProtKB=O35099	Mitogen-activated protein kinase kinase kinase 5	RCA	12968034	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	RCA	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00017	DNA replication	P00527	Histones	MACMU|Ensembl=ENSMMUG00000032235|UniProtKB=H9H5I5	Histone H3	ISS	12413958	PubMed	PTHR11426:SF179	HISTONE H3.3
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01305	Calmodulin	DANRE|Ensembl=ENSDARG00000015050|UniProtKB=Q6PI52	Calmodulin	ISS	9753452	PubMed	PTHR23050:SF326	CALMODULIN
P05913	Enkephalin release	P05977	G-Protein (s)	TAKRU|Ensembl=ENSTRUG00000011297|UniProtKB=H2TV18	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00053	T cell activation	P01307	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00006	Apoptosis signaling pathway	P00269	MAPK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	92020947	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00796	Kainate receptor	HUMAN|HGNC=4580|UniProtKB=Q13002	Glutamate receptor ionotropic, kainate 2	IDA	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05913	Enkephalin release	P05974	G-Protein (i)	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	IC	8170357	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	BOVIN|Ensembl=ENSBTAG00000039772|UniProtKB=F6QI78	Uncharacterized protein	ISS	11859080	PubMed	PTHR24247:SF31	5-HYDROXYTRYPTAMINE RECEPTOR 2B
P06664	Gonadotropin-releasing hormone receptor pathway	P06852	nPKCs	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014262|UniProtKB=F7BYS8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00718	Phosphorylase a	MOUSE|MGI=MGI=97829|UniProtKB=Q9ET01	Glycogen phosphorylase, liver form	IDA	4318782	PubMed	PTHR11468:SF12	GLYCOGEN PHOSPHORYLASE, LIVER FORM
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01211	ERK	RAT|RGD=628675|UniProtKB=Q9Z2A6	Mitogen-activated protein kinase 15	IDA	12787066	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P04398	p53 pathway feedback loops 2	P04668	p53	PANTR|Ensembl=ENSPTRG00000015733|UniProtKB=H2QNY5	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00021	FGF signaling pathway	P00629	PP2A	NEUCR|EnsemblGenome=EFNCRG00000006305|UniProtKB=Q1K8E8	Serine/threonine-protein phosphatase	ISS			PTHR11668:SF25	SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-LIKE PPG1
P04397	p53 pathway by glucose deprivation	P04641	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00049	Parkinson disease	P01236	Casein kinase II	MONDO|Ensembl=ENSMODG00000015287|UniProtKB=F6T6M8	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00006	Apoptosis signaling pathway	P00260	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00059	p53 pathway	P04633	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	RAT|RGD=620198|UniProtKB=Q10739	Matrix metalloproteinase-14	TAS	12834808	PubMed	PTHR10201:SF24	MATRIX METALLOPROTEINASE-14
P05730	Endogenous cannabinoid signaling	P05751	Galpha	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00557	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04373	5HT1 type receptor mediated signaling pathway	P04407	K+ channel	MACMU|Ensembl=ENSMMUG00000005826|UniProtKB=F6VE51	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00046	Oxidative stress response	P01132	c-jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00045	Notch signaling pathway	P01113	Pen-2	RAT|RGD=621060|UniProtKB=O88777	Presenilin-2	IEP	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00021	FGF signaling pathway	P00636	FGFR1-4	PANTR|Ensembl=ENSPTRG00000020176|UniProtKB=H2R210	Fibroblast growth factor receptor	ISS	12799194	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	XENTR|Xenbase=XB-GENE-479036|UniProtKB=Q640R7	Ras-related protein Rap-1b	ISS	8576107	PubMed	PTHR24070:SF382	RAS-RELATED PROTEIN RAP-1B
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	PANTR|Ensembl=ENSPTRG00000013428|UniProtKB=H2QK88	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF358	MYOSIN-7B
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12874273	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00054	Toll receptor signaling pathway	G01550	Gene trancription	BOVIN|Ensembl=ENSBTAG00000046456|UniProtKB=G3MWZ5	Uncharacterized protein	ISS			PTHR11691:SF43	INTERFERON BETA
P06959	CCKR signaling map	P07073	FOXO3	HUMAN|HGNC=3821|UniProtKB=O43524	Forkhead box protein O3	RCA	15351698	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P04398	p53 pathway feedback loops 2	P04665	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00110	Ire-1 N-terminal fragment	RAT|RGD=1308743|UniProtKB=D3ZTI7	Endoplasmic reticulum (ER) to nucleus signalling 2 (Predicted)	ISS	10619423	PubMed	PTHR13954:SF15	SERINE/THREONINE-PROTEIN KINASE/ENDORIBONUCLEASE IRE2
P00021	FGF signaling pathway	P00648	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IGI	22533439	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00030	Hypoxia response via HIF activation	P00814	P300	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	IDA	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00034	Integrin signalling pathway	P00907	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	TAS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00034	Integrin signalling pathway	P00927	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	IGI	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	XENTR|Xenbase=XB-GENE-6035431|UniProtKB=F6RJ06	Uncharacterized protein	ISS	11248120	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P04398	p53 pathway feedback loops 2	G04714	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00047	PDGF signaling pathway	P01171	PLCgamma	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	CHICK|Gene_ORFName=RCJMB04_24e7|UniProtKB=P62149	Calmodulin	ISS	10487978	PubMed	PTHR23050:SF311	CALMODULIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2522|UniProtKB=P30729	D(4) dopamine receptor	IDA	12181435	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P02729	Ascorbate degradation	P02852	L-xylulose-5-phosphate-3-epimerase	CAEEL|WormBase=WBGene00017272|UniProtKB=Q95ZW2	Ribulose-phosphate 3-epimerase	ISS			PTHR11749:SF3	RIBULOSE-PHOSPHATE 3-EPIMERASE
P00019	Endothelin signaling pathway	P00590	IP3 R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00004	Alzheimer disease-presenilin pathway	P00113	Erb-B4 transmembrane fragment	CHICK|Ensembl=ENSGALG00000003126|UniProtKB=F1P258	Receptor protein-tyrosine kinase	ISS	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00018	EGF receptor signaling pathway	P00539	14-3-3	CANLF|Ensembl=ENSCAFG00000009514|UniProtKB=F1PKW7	Uncharacterized protein	ISS	12618428	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00012	Cadherin signaling pathway	P00467	alpha-catenin	MACMU|Ensembl=ENSMMUG00000016902|UniProtKB=F7FBX6	Uncharacterized protein	ISS	9362521	PubMed	PTHR18914:SF21	CATENIN ALPHA-3
P00019	Endothelin signaling pathway	P00584	Gs	CHICK|Ensembl=ENSGALG00000007509|UniProtKB=F1NM72	Uncharacterized protein	ISS	6309844	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	BOVIN|Ensembl=ENSBTAG00000019210|UniProtKB=F1MJV4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	RAT|RGD=61985|UniProtKB=Q62833	G protein-coupled receptor kinase 5	RCA			PTHR24355:SF27	G PROTEIN-COUPLED RECEPTOR KINASE 5
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	ISS	15860573	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P04393	Ras Pathway	P04558	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00590	IP3 R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00774	Dynein complex	STRPU|EnsemblGenome=SPU_004377|UniProtKB=W4XLU7	Uncharacterized protein	ISS	9454836	PubMed	PTHR11886:SF2	DYNEIN LIGHT CHAIN 4, AXONEMAL
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	RCA	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00053	T cell activation	P01307	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ARATH|TAIR=AT3G18040|UniProtKB=Q9LV37	Mitogen-activated protein kinase 9	IDA			PTHR24055:SF246	MITOGEN-ACTIVATED PROTEIN KINASE 15-RELATED
P00005	Angiogenesis	P00211	GSK3beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=1310389|UniProtKB=D3ZTF6	Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Predicted), isoform CRA_a	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00005	Angiogenesis	P00217	STAT3	HUMAN|HGNC=11364|UniProtKB=P40763	Signal transducer and activator of transcription 3	IDA	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00021	FGF signaling pathway	P00641	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04372	5-Hydroxytryptamine degredation	P04401	Monoamine Oxidase	MYCTU|EnsemblGenome=Rv3170|UniProtKB=P9WQ15	Putative flavin-containing monoamine oxidase AofH	ISS			PTHR43563:SF2	AMINE OXIDASE  FLAVIN-CONTAINING
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02788	Xanthine and guanine salvage pathway	P03247	Xanthine phosphoribosyl transferase	LEIMA|EnsemblGenome=LmjF.21.0850|UniProtKB=Q4QCC2	Xanthine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00005	Angiogenesis	P00217	STAT3	HUMAN|HGNC=11364|UniProtKB=P40763	Signal transducer and activator of transcription 3	IDA	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=15906|UniProtKB=A7E2Y1	Myosin-7B	IC	89264452	PubMed	PTHR13140:SF358	MYOSIN-7B
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00045	Notch signaling pathway	G01541	E(spl)-C genes	PANTR|Ensembl=ENSPTRG00000015753|UniProtKB=H2QNZ9	Hairy and enhancer of split 1	ISS	14973298	PubMed	PTHR10985:SF19	TRANSCRIPTION FACTOR HES-1
P00029	Huntington disease	P00780	Microtubule	HUMAN|HGNC=20778|UniProtKB=P07437	Tubulin beta chain	IDA	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MACMU|Ensembl=ENSMMUG00000007027|UniProtKB=F7F210	Alpha-cardiac actin	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00046	Oxidative stress response	P01133	Max	PANTR|Ensembl=ENSPTRG00000006449|UniProtKB=H2Q8G8	MYC associated factor X	ISS	11274345	PubMed	PTHR10328:SF3	PROTEIN MAX
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	TAS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	ARATH|TAIR=AT1G60490|UniProtKB=P42339	Phosphatidylinositol 3-kinase VPS34	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IDA	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00021	FGF signaling pathway	P00629	PP2A	HUMAN|HGNC=9309|UniProtKB=Q15172	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform	IPI	10092233	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00780	Microtubule	YEAST|SGD=S000001857|UniProtKB=P02557	Tubulin beta chain	IDA	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00047	PDGF signaling pathway	P01145	c-fos	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00023	General transcription regulation	P00668	TFIIB	PYRAE|EnsemblGenome=PAE1645|UniProtKB=Q8ZWS3	Transcription initiation factor IIB	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00057	Wnt signaling pathway	P01464	Pygo	MACMU|Ensembl=ENSMMUG00000004652|UniProtKB=F6T6J6	Uncharacterized protein	ISS	11955446	PubMed	PTHR23194:SF3	PYGOPUS HOMOLOG 1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	HALSA|EnsemblGenome=VNG_2383G|UniProtKB=Q9HMU4	Ribonucleoside reductase small chain	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00001	Adrenaline and noradrenaline biosynthesis	P00067	MAO	RAT|RGD=3041|UniProtKB=P19643	Amine oxidase [flavin-containing] B	ISS	90344230	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02763	Peptidoglycan biosynthesis	P03091	D-alanine-D-alanine ligase	FUSNN|EnsemblGenome=FN1454|UniProtKB=Q8RDQ4	D-alanine--D-alanine ligase	ISS			PTHR23132:SF12	D-ALANINE--D-ALANINE LIGASE B
P00056	VEGF signaling pathway	P01411	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P02756	N-acetylglucosamine metabolism	P03036	N-acetylglucosamine-6-phosphate deacetylase	SULSO|EnsemblGenome=SSO2673|UniProtKB=Q97VF3	N-acetylglucosamine-6-phosphate deacetylase (NagA)	ISS			PTHR11113:SF1	N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P06959	CCKR signaling map	P07159	BAX	HUMAN|HGNC=959|UniProtKB=Q07812	Apoptosis regulator BAX	RCA	8358790	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P00021	FGF signaling pathway	P00629	PP2A	PHANO|EnsemblGenome=SNOG_16549|UniProtKB=Q0TVB5	Protein phosphatase PP2A regulatory subunit B	ISS	9987122	PubMed	PTHR11871:SF0	PROTEIN PHOSPHATASE PP2A 55 KDA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	MACMU|Ensembl=ENSMMUG00000007096|UniProtKB=F7ERG6	G protein-activated inward rectifier potassium channel 1	ISS	2433589	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00019	Endothelin signaling pathway	P00568	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IGI	22040490	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05730	Endogenous cannabinoid signaling	P05743	CB1	CHICK|Ensembl=ENSGALG00000015789|UniProtKB=F1NJC1	Uncharacterized protein	ISS	9888857	PubMed	PTHR22750:SF47	CANNABINOID RECEPTOR 1
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00790	beta-Tubulin	ORYSJ|EnsemblGenome=OS06G0671900|UniProtKB=Q40665	Tubulin beta-3 chain	TAS	12932731	PubMed	PTHR11588:SF245	TUBULIN BETA-4 CHAIN-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DANRE|ZFIN=ZDB-GENE-040426-1354|UniProtKB=Q7T2C5	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00034	Integrin signalling pathway	P00938	Cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P01486	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	HUMAN|HGNC=1388|UniProtKB=O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	15699344	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00927	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	8649368	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	MONDO|Ensembl=ENSMODG00000020977|UniProtKB=F6S5B1	Uncharacterized protein (Fragment)	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00029	Huntington disease	P00807	Actin	PRIPA|Gene=PPA23459|UniProtKB=H3FMF2	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05731	GABA-B receptor II signaling	P05752	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	LEIMA|EnsemblGenome=LmjF.35.4010|UniProtKB=Q9GNR4	Protein kinase A catalytic subunit isoform 1	IC	14744463	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MACMU|Ensembl=ENSMMUG00000017683|UniProtKB=F6UA63	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P02774	Salvage pyrimidine deoxyribonucleotides	P03146	Deoxyuridine kinase	HALSA|EnsemblGenome=VNG_1515G|UniProtKB=Q9HPQ9	Thymidine kinase	ISS			PTHR11441:SF0	THYMIDINE KINASE, CYTOSOLIC
P00021	FGF signaling pathway	P00636	FGFR1-4	BOVIN|Ensembl=ENSBTAG00000015457|UniProtKB=A4IFL5	Fibroblast growth factor receptor	ISS	9989949	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P00016	Cytoskeletal regulation by Rho GTPase	P00507	Rho	BOVIN|Ensembl=ENSBTAG00000014299|UniProtKB=Q1RMJ6	Rho-related GTP-binding protein RhoC	ISS	14871999	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00053	T cell activation	P01324	rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12932731	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00030	Hypoxia response via HIF activation	P00819	AKT	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P06959	CCKR signaling map	G06969	HDC	HUMAN|HGNC=4855|UniProtKB=P19113	Histidine decarboxylase	RCA	9142914	PubMed	PTHR11999:SF68	HISTIDINE DECARBOXYLASE
P00049	Parkinson disease	P01211	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	8946911	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01314	nck	BOVIN|Ensembl=ENSBTAG00000018427|UniProtKB=Q1LZB2	NCK adaptor protein 1	ISS	12874226	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	BOVIN|Ensembl=ENSBTAG00000020079|UniProtKB=F1N3T0	Uncharacterized protein	ISS	602425	OMIM	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00846	JAK	RAT|RGD=2939|UniProtKB=Q62689	Tyrosine-protein kinase JAK2	ISS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00036	Interleukin signaling pathway	P00981	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02736	Coenzyme A biosynthesis	P02884	Dephospho-CoA kinase	ORYSJ|EnsemblGenome=OS01G0360600|UniProtKB=Q94DR2	Dephospho-CoA kinase	ISS			PTHR10695:SF35	DEPHOSPHO-COA KINASE DOMAIN-CONTAINING PROTEIN
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	MOUSE|MGI=MGI=99685|UniProtKB=E9Q401	Ryanodine receptor 2	ISS	8930069	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000005917|UniProtKB=F6QM53	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	HUMAN|HGNC=4583|UniProtKB=Q16478	Glutamate receptor ionotropic, kainate 5	ISS	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TAKRU|Ensembl=ENSTRUG00000005447|UniProtKB=P68142	Actin, cytoplasmic 1	IC	11889126	PubMed	PTHR11937:SF354	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	TAKRU|Ensembl=ENSTRUG00000007501|UniProtKB=H2T1P2	Clathrin heavy chain	ISS	9388255	PubMed	PTHR10292:SF1	CLATHRIN HEAVY CHAIN
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00036	Interleukin signaling pathway	P00977	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00035	Interferon-gamma signaling pathway	P00958	PIAS	MONDO|Ensembl=ENSMODG00000003324|UniProtKB=F7DDM9	Uncharacterized protein	ISS	8682149	PubMed	PTHR10782:SF12	E3 SUMO-PROTEIN LIGASE PIAS2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	SCHPO|PomBase=SPCC576.15c|UniProtKB=Q12701	Serine/threonine-protein kinase ksg1	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000014733|UniProtKB=F7GVJ2	Uncharacterized protein	ISS	8120095	PubMed	PTHR43956:SF3	CADHERIN-23
P00047	PDGF signaling pathway	P01161	Raf	DROME|FlyBase=FBgn0003079|UniProtKB=P11346	Raf homolog serine/threonine-protein kinase phl	ISS	125651	gi	PTHR44000:SF2	RAF HOMOLOG SERINE/THREONINE-PROTEIN KINASE PHL
P02729	Ascorbate degradation	P02852	L-xylulose-5-phosphate-3-epimerase	MACMU|Ensembl=ENSMMUG00000010513|UniProtKB=F7B8C1	Ribulose-phosphate 3-epimerase	ISS			PTHR11749:SF3	RIBULOSE-PHOSPHATE 3-EPIMERASE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014555|UniProtKB=F7GT55	Syntaxin-1A isoform 1	ISS	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00034	Integrin signalling pathway	P00927	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	MONDO|Ensembl=ENSMODG00000012785|UniProtKB=F6S0M5	Uncharacterized protein	ISS	604904	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	SCHMA|EnsemblGenome=Smp_049760|UniProtKB=G4LWP9	Receptor protein serine/threonine kinase	TAS	9395284	PubMed	PTHR23255:SF71	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	TAS			PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00036	Interleukin signaling pathway	P00973	PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	PANTR|Ensembl=ENSPTRG00000003699|UniProtKB=H2Q3R5	Syntaxin 3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=1339712|UniProtKB=P13542	Myosin-8	IC	89264452	PubMed	PTHR13140:SF368	MYOSIN-8
P00036	Interleukin signaling pathway	P00990	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95816|UniProtKB=B1AS29	Glutamate receptor ionotropic, kainate 3	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00011	Blood coagulation	P00403	EPCR	MACMU|Ensembl=ENSMMUG00000018140|UniProtKB=F7F7R4	Endothelial cell protein C receptor	ISS	13626550	gi	PTHR15349:SF0	ENDOTHELIAL PROTEIN C RECEPTOR
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ORNAN|Ensembl=ENSOANG00000007581|UniProtKB=F6QWB7	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00048	PI3 kinase pathway	P01189	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	HUMAN|HGNC=6698|UniProtKB=O75581	Low-density lipoprotein receptor-related protein 6	IDA	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1203729|UniProtKB=Q61194	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	ARATH|TAIR=AT5G07880|UniProtKB=Q9SD96	SNAP25 homologous protein SNAP29	ISS			PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00057	Wnt signaling pathway	P01435	SWI/SNF	HUMAN|HGNC=11099|UniProtKB=Q14527	Helicase-like transcription factor	IDA	11532957	PubMed	PTHR10799:SF870	HELICASE-LIKE TRANSCRIPTION FACTOR
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	MACMU|Ensembl=ENSMMUG00000003857|UniProtKB=F7HA84	Nucleoside diphosphate kinase	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	DANRE|ZFIN=ZDB-GENE-040801-83|UniProtKB=Q6DEG5	Polymerase (RNA) II (DNA directed) polypeptide E	ISS	11313498	gi	PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	LEIMA|EnsemblGenome=LmjF.18.1080|UniProtKB=Q27687	Protein kinase A catalytic subunit	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00059	p53 pathway	P01484	Chk2	MOUSE|MGI=MGI=1355321|UniProtKB=Q9Z265	Serine/threonine-protein kinase Chk2	IGI	12356735	PubMed	PTHR44167:SF1	SERINE/THREONINE-PROTEIN KINASE CHK2
P00007	Axon guidance mediated by semaphorins	P00336	Cdk5	TAKRU|Ensembl=ENSTRUG00000004034|UniProtKB=H2SAY8	Uncharacterized protein	ISS	10604473,	PubMed	PTHR24056:SF46	CYCLIN-DEPENDENT-LIKE KINASE 5
P00059	p53 pathway	P01486	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00310	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IDA	96009592	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00018	EGF receptor signaling pathway	P00564	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P05916	Opioid prodynorphin pathway	P06001	AC	RAT|RGD=619965|UniProtKB=P26769	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05913	Enkephalin release	P05974	G-Protein (i)	ANOGA|EnsemblGenome=AGAP001506|UniProtKB=Q7PXP3	AGAP001506-PA	IC			PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	DROME|FlyBase=FBgn0002413|UniProtKB=O76324	Discs overgrown protein kinase	IDA	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00010	B cell activation	P00384	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00006	Apoptosis signaling pathway	P00269	MAPK	YEAST|SGD=S000003272|UniProtKB=P14681	Mitogen-activated protein kinase KSS1	ISS	6321477	gi	PTHR24055:SF338	MITOGEN-ACTIVATED PROTEIN KINASE KSS1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02728	Arginine biosynthesis	P02840	Argininosuccinate synthase	BOVIN|Ensembl=ENSBTAG00000020747|UniProtKB=P14568	Argininosuccinate synthase	ISS			PTHR11587:SF2	ARGININOSUCCINATE SYNTHASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	9836512	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	9754712	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=3230|UniProtKB=Q9NYQ7	Cadherin EGF LAG seven-pass G-type receptor 3	IDA	8120095	PubMed	PTHR24026:SF38	CADHERIN EGF LAG SEVEN-PASS G-TYPE RECEPTOR 3
P04393	Ras Pathway	P04569	Cdc42	PRIPA|Gene=PPA22610|UniProtKB=H3FK05	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04559	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00010	B cell activation	P00398	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	ARATH|TAIR=AT3G13670|UniProtKB=Q9LID3	Casein kinase-like protein	IDA	11437445	PubMed	PTHR11909:SF289	CASEIN KINASE-LIKE PROTEIN
P00005	Angiogenesis	P00223	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00034	Integrin signalling pathway	P00907	ERK	CANLF|Ensembl=ENSCAFG00000015640|UniProtKB=E2QVF3	Uncharacterized protein	ISS	8444355	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CAEEL|WormBase=WBGene00000061|UniProtKB=G5EGR1	Acetylcholine receptor (51.1 kD) (Acr-22)	IC			PTHR18945:SF529	ACETYLCHOLINE RECEPTOR  51.1 KD   ACR-22 -RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	HUMAN|HGNC=7777|UniProtKB=Q12968	Nuclear factor of activated T-cells, cytoplasmic 3	ISS	12015605	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00053	T cell activation	P01306	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CHICK|Gene=JUN|UniProtKB=P18870	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00632	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MACMU|Ensembl=ENSMMUG00000018568|UniProtKB=F6YLW2	Uncharacterized protein	ISS	21735556	gi	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00029	Huntington disease	G01530	HTT	RAT|RGD=68337|UniProtKB=P51111	Huntingtin	IDA	9462744	PubMed	PTHR10170:SF10	HUNTINGTIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MONDO|Ensembl=ENSMODG00000015246|UniProtKB=F6UJF5	Uncharacterized protein	ISS			PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MOUSE|MGI=MGI=95691|UniProtKB=O08689	Growth/differentiation factor 8	TAS	9759503	PubMed	PTHR11848:SF150	GROWTH/DIFFERENTIATION FACTOR 8
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DAPPU|EnsemblGenome=DAPPUDRAFT_188187|UniProtKB=E9GJ31	Guanine nucleotide binding protein, q polypeptide	ISS	9166716	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00047	PDGF signaling pathway	P01160	IP3 receptor	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00006	Apoptosis signaling pathway	P00299	Caspase 8	RAT|RGD=620945|UniProtKB=Q9JHX4	Caspase-8	ISS	8681376	PubMed	PTHR10454:SF162	CASPASE-8
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	CAEBR|Gene=CBG20737|UniProtKB=A8XYH6	Protein CBR-GLN-2	ISS			PTHR20852:SF57	GLUTAMINE SYNTHETASE 2 CYTOPLASMIC
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DICPU|Gene=DICPUDRAFT_48914|UniProtKB=F0ZK40	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF154	ACTIN-17-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	CANLF|Ensembl=ENSCAFG00000016653|UniProtKB=E2R3E4	Uncharacterized protein	ISS	1370475	PubMed	PTHR44087:SF2	PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, LIVER/TESTIS ISOFORM
P00048	PI3 kinase pathway	P01192	p110	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P04609	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	ISS	1171954	gi	PTHR10048:SF14	PI-3 KINASE
P02772	Pyruvate metabolism	P03137	Citrate Lyase	SULSO|EnsemblGenome=SSO1254|UniProtKB=Q97YR5	Citryl-CoA lyase beta subunit homolog (CitE)	ISS			PTHR32308:SF0	CITRATE LYASE SUBUNIT BETA
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00009	Axon guidance mediated by netrin	P00363	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000014498|UniProtKB=F7GEI8	Uncharacterized protein	ISS	14624853	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00023	General transcription regulation	P00660	RNA Polymerase II	ORNAN|Ensembl=ENSOANG00000010454|UniProtKB=F6SGR6	Uncharacterized protein	ISS	606023	OMIM	PTHR10917:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3
P00018	EGF receptor signaling pathway	P00545	JNK1-3	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00055	Transcription regulation by bZIP transcription factor	P01395	TFIIE	RAT|RGD=1306851|UniProtKB=G3V992	General transcription factor II E, polypeptide 1 (Alpha subunit)	ISS	189962	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00010	B cell activation	P00383	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00022	General transcription by RNA polymerase I	P00657	TBP	DROME|FlyBase=FBgn0003687|UniProtKB=P20227	TATA-box-binding protein	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_126324|UniProtKB=C3XYC2	Putative uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PANTR|Ensembl=ENSPTRG00000008746|UniProtKB=H2QC84	Myosin, heavy chain 10, non-muscle	ISS	89264452	PubMed	PTHR13140:SF328	MYOSIN-10
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P06959	CCKR signaling map	P07222	MEF2C	HUMAN|HGNC=6996|UniProtKB=Q06413	Myocyte-specific enhancer factor 2C	RCA		PubMed	PTHR11945:SF25	MYOCYTE-SPECIFIC ENHANCER FACTOR 2C
P02732	Coenzyme A linked carnitine metabolism	P02864	L-carnitine dehydratase	PSEAE|EnsemblGenome=PA3733|UniProtKB=Q9HXQ9	Uncharacterized protein	ISS			PTHR43949:SF1	ACETYL-COA:OXALATE COA-TRANSFERASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Ensembl=ENSCAFG00000001738|UniProtKB=E2RDG9	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00010	B cell activation	P00384	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00019	Endothelin signaling pathway	P00573	signal peptidase	HUMAN|HGNC=17718|UniProtKB=P67812	Signal peptidase complex catalytic subunit SEC11A	ISS	2674115	PubMed	PTHR10806:SF8	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11A-RELATED
P05913	Enkephalin release	P05974	G-Protein (i)	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	MACMU|Ensembl=ENSMMUG00000010987|UniProtKB=F7GCX9	Uncharacterized protein	ISS	12497607	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00011	Blood coagulation	P00445	FXa	MOUSE|MGI=MGI=103107|UniProtKB=O88947	Coagulation factor X	ISS	13278040	gi	PTHR44064:SF3	COAGULATION FACTOR X
P00021	FGF signaling pathway	P00629	PP2A	MONDO|Ensembl=ENSMODG00000016691|UniProtKB=F7DLW2	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B (Fragment)	ISS	11956189	PubMed	PTHR11871:SF2	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	PANTR|Ensembl=ENSPTRG00000000543|UniProtKB=H2PYN8	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00046	Oxidative stress response	P01138	MKK4	MACMU|Ensembl=ENSMMUG00000019842|UniProtKB=F7FU91	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00036	Interleukin signaling pathway	P00995	c-Myc	PANTR|Gene=MYC|UniProtKB=P23583	Myc proto-oncogene protein	ISS	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	IC	15313841	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01188	Gbetagamma	DANRE|ZFIN=ZDB-GENE-070112-342|UniProtKB=A1L271	Uncharacterized protein	ISS	10051575	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00053	T cell activation	P01312	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P05731	GABA-B receptor II signaling	P05754	Ggamma	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00047	PDGF signaling pathway	P01151	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	DANRE|ZFIN=ZDB-GENE-030131-6609|UniProtKB=Q7ZV11	Polymerase (RNA) II (DNA directed) polypeptide C	ISS	2187864	PubMed	PTHR11800:SF2	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04393	Ras Pathway	P04567	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IDA	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BOVIN|Ensembl=ENSBTAG00000005714|UniProtKB=Q3ZC07	Actin, alpha cardiac muscle 1	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00060	Ubiquitin proteasome pathway	P01491	E2	ORNAN|Ensembl=ENSOANG00000012614|UniProtKB=F7FZ60	Uncharacterized protein	ISS			PTHR24068:SF48	UBIQUITIN-CONJUGATING ENZYME E2 D3
P00021	FGF signaling pathway	P00646	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	11847220	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00053	T cell activation	P01306	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	TAKRU|Ensembl=ENSTRUG00000006611|UniProtKB=H2SV11	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	ANOGA|EnsemblGenome=AGAP006475|UniProtKB=Q5TQX0	AGAP006475-PA	ISS	12880387	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00010	B cell activation	P00391	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	TAS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_56687|UniProtKB=C3YC50	Putative uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01177	P110ACT	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	9009705	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00007	Axon guidance mediated by semaphorins	P00332	Fes	CANLF|Ensembl=ENSCAFG00000012298|UniProtKB=F1PUK7	Tyrosine-protein kinase	ISS			PTHR24418:SF197	TYROSINE-PROTEIN KINASE FES/FPS
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00038	JAK/STAT signaling pathway	P01027	STAT	PANTR|Ensembl=ENSPTRG00000005121|UniProtKB=H2Q6A5	Uncharacterized protein	ISS	94367369	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00587	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	BOVIN|Gene=CACNB1|UniProtKB=Q9MZL7	Voltage-dependent L-type calcium channel subunit beta-1	IC	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05915	Opioid proenkephalin pathway	P05994	G-protein	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00029	Huntington disease	P00807	Actin	DICDI|dictyBase=DDB_G0268744|UniProtKB=Q55EU6	Putative actin-23	IDA	11889126	PubMed	PTHR11937:SF154	ACTIN-17-RELATED
P02785	Valine biosynthesis	P03218	Dihydroxy isovalerate dehydratase	BACSU|EnsemblGenome=BSU21870|UniProtKB=P51785	Dihydroxy-acid dehydratase	ISS			PTHR43661:SF3	DIHYDROXY-ACID DEHYDRATASE
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	BOVIN|Ensembl=ENSBTAG00000020957|UniProtKB=F1MGM1	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF126	FRIZZLED-5
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01465	Ggamma	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00034	Integrin signalling pathway	P00922	Collagen	MACMU|Ensembl=ENSMMUG00000022280|UniProtKB=F7EGF5	Uncharacterized protein	ISS	10778855	PubMed	PTHR24023:SF854	COLLAGEN ALPHA-1 IV  CHAIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00029	Huntington disease	P00778	NMDA receptor	DANRE|ZFIN=ZDB-GENE-051202-1|UniProtKB=E7F101	Uncharacterized protein	ISS	11319238	PubMed	PTHR44391:SF2	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01402	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	RCA			PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02775	Salvage pyrimidine ribonucleotides	P03150	Uridine kinase	MACMU|Ensembl=ENSMMUG00000009976|UniProtKB=F6R3B0	Uridine-cytidine kinase	ISS			PTHR10285:SF66	URIDINE-CYTIDINE KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01162	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	MACMU|Ensembl=ENSMMUG00000012610|UniProtKB=F7F5C0	Uncharacterized protein	ISS	15032587	PubMed	PTHR44562:SF1	SUPPRESSOR OF CYTOKINE SIGNALING 6
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=12786|UniProtKB=O00755	Protein Wnt-7a	TAS	8717036	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00052	TGF-beta signaling pathway	P01279	Smurfs	CHICK|Ensembl=ENSGALG00000003566|UniProtKB=F1NJU6	Uncharacterized protein	ISS	11252892	PubMed	PTHR11254:SF300	E3 UBIQUITIN-PROTEIN LIGASE SMURF2
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	MONDO|Ensembl=ENSMODG00000000129|UniProtKB=F6YB95	Uncharacterized protein	ISS	9043084	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01239	Cul-1	DICPU|Gene=DICPUDRAFT_44981|UniProtKB=F0Z8D7	Cullin	ISS	12628165	PubMed	PTHR11932:SF125	CULLIN-1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	RAT|RGD=3698|UniProtKB=P24942	Excitatory amino acid transporter 1	IC	94365697	PubMed	PTHR11958:SF24	EXCITATORY AMINO ACID TRANSPORTER 1
P00030	Hypoxia response via HIF activation	P00825	Thioredoxin	HUMAN|HGNC=12435|UniProtKB=P10599	Thioredoxin	ISS	12115731	PubMed	PTHR10438:SF18	THIOREDOXIN
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P05913	Enkephalin release	P05972	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00021	FGF signaling pathway	P00645	Rac	CAEEL|WormBase=WBGene00000424|UniProtKB=Q03206	Ras-related protein ced-10	IGI	12932731	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P02740	De novo pyrimidine ribonucleotides biosythesis	P02927	Dihydrooratate oxidase	RAT|RGD=68352|UniProtKB=Q63707	Dihydroorotate dehydrogenase (quinone), mitochondrial	ISS			PTHR43517:SF1	DIHYDROOROTATE DEHYDROGENASE  QUINONE , MITOCHONDRIAL
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05918	p38 MAPK pathway	P06039	MSK2	HUMAN|HGNC=10433|UniProtKB=O75676	Ribosomal protein S6 kinase alpha-4	RCA	6755374	gi	PTHR24351:SF41	RIBOSOMAL PROTEIN S6 KINASE ALPHA-4
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	ARATH|TAIR=AT4G02120|UniProtKB=Q8L6Z9	CTP synthase	ISS			PTHR11550:SF0	CTP SYNTHASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CHICK|Ensembl=ENSGALG00000009844|UniProtKB=P68034	Actin, alpha cardiac muscle 1	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00018	EGF receptor signaling pathway	P00539	14-3-3	CHICK|Ensembl=ENSGALG00000006743|UniProtKB=Q5ZKJ2	Uncharacterized protein	ISS	6756037	gi	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00057	Wnt signaling pathway	P01465	Ggamma	MACMU|Ensembl=ENSMMUG00000010392|UniProtKB=F7ASR8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	IDA	10207617	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	IPI	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00029	Huntington disease	P00780	Microtubule	MACMU|Ensembl=ENSMMUG00000013187|UniProtKB=F6XQ37	Tubulin beta-1 chain	ISS	9454836	PubMed	PTHR11588:SF112	TUBULIN BETA-1 CHAIN
P00018	EGF receptor signaling pathway	P00539	14-3-3	DANRE|ZFIN=ZDB-GENE-011115-1|UniProtKB=Q6PC29	14-3-3 protein gamma-1	ISS	22165492	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00005	Angiogenesis	P00256	PLC-gamma	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00011	Blood coagulation	P00418	Fibrin monomer	HUMAN|HGNC=3662|UniProtKB=P02675	Fibrinogen beta chain	ISS	223002	gi	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00021	FGF signaling pathway	P00646	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	88318957	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00046	Oxidative stress response	P01135	p38	DANRE|ZFIN=ZDB-GENE-990415-257|UniProtKB=O42376	Mitogen-activated protein kinase 12	TAS	10851062	PubMed	PTHR24055:SF339	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PHYPA|Gene=PHYPADRAFT_198730|UniProtKB=Q6TYS2	Actin 1	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8677|UniProtKB=Q9Y5I4	Protocadherin alpha-C2	IDA	8120095	PubMed	PTHR24028:SF119	PROTOCADHERIN ALPHA-C2
P00019	Endothelin signaling pathway	P00577	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95814|UniProtKB=Q60934	Glutamate receptor ionotropic, kainate 1	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00046	Oxidative stress response	P01135	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	TAS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00640	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00566	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-030131-9966|UniProtKB=Q6TH03	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P02759	Pyridoxal-5-phosphate biosynthesis	P03062	1-Deoxyxylulose-5-phosphate synthase	DEIRA|EnsemblGenome=DR_1475|UniProtKB=Q9RUB5	1-deoxy-D-xylulose-5-phosphate synthase	ISS			PTHR43322:SF5	1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE 1-RELATED
P00036	Interleukin signaling pathway	P00977	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	RAT|RGD=1563369|UniProtKB=Q5U2N0	CTP synthase 2	ISS			PTHR11550:SF2	CTP SYNTHASE 2
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=11429|UniProtKB=O75558	Syntaxin-11	ISS	11067767	PubMed	PTHR19957:SF30	SYNTAXIN-11
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00046	Oxidative stress response	P01131	MKP5	MACMU|Ensembl=ENSMMUG00000004379|UniProtKB=F7FRM2	Dual specificity protein phosphatase 10 isoform a	ISS	11856337	PubMed	PTHR10159:SF299	DUAL SPECIFICITY PROTEIN PHOSPHATASE 10
P00006	Apoptosis signaling pathway	P00269	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	DANRE|Ensembl=ENSDARG00000070511|UniProtKB=E7F5R2	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF282	GLUTAMATE RECEPTOR-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00057	Wnt signaling pathway	P01464	Pygo	PANTR|Ensembl=ENSPTRG00000038970|UniProtKB=H2RG65	Uncharacterized protein	ISS	11955446	PubMed	PTHR23194:SF3	PYGOPUS HOMOLOG 1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	BACSU|EnsemblGenome=BSU40420|UniProtKB=P29726	Adenylosuccinate synthetase	IEP	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P05913	Enkephalin release	P05974	G-Protein (i)	DAPPU|EnsemblGenome=DAPPUDRAFT_59367|UniProtKB=E9H7Z0	Guanine nucleotide-binding protein G(O) subunit alpha 1	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00864	MEK	MOUSE|MGI=MGI=1346875|UniProtKB=O08648	Mitogen-activated protein kinase kinase kinase 4	TAS			PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P02759	Pyridoxal-5-phosphate biosynthesis	P03058	Phosphohydroxythreonine aminotransferase	RAT|RGD=735170|UniProtKB=A0A0G2K931	Phosphoserine aminotransferase	ISS	20886743	gi	PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P00029	Huntington disease	P00811	Arp2/3 complex	MACMU|Ensembl=ENSMMUG00000001458|UniProtKB=F7BKH1	Uncharacterized protein	ISS	12963527	gi	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	ORNAN|Ensembl=ENSOANG00000010302|UniProtKB=F6TDQ6	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00006	Apoptosis signaling pathway	P00318	PKCs	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IDA	22533439	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MOUSE|MGI=MGI=109521|UniProtKB=P35363	5-hydroxytryptamine receptor 2A	IDA			PTHR24247:SF30	5-HYDROXYTRYPTAMINE RECEPTOR 2A
P00006	Apoptosis signaling pathway	P00309	Smac/Diablo	RAT|RGD=1310885|UniProtKB=Q5RK17	Diablo homolog (Drosophila)	ISS	10929712	PubMed	PTHR32247:SF3	DIABLO HOMOLOG, MITOCHONDRIAL
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00048	PI3 kinase pathway	P01179	PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00020	FAS signaling pathway	P00600	PARP	CANLF|Ensembl=ENSCAFG00000016089|UniProtKB=F1Q2M3	Poly [ADP-ribose] polymerase	ISS	12101391	PubMed	PTHR10459:SF80	POLY  ADP-RIBOSE  POLYMERASE 1
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	PANTR|Ensembl=ENSPTRG00000003554|UniProtKB=H2Q3I3	Low density lipoprotein receptor-related protein 4	ISS	11907044	PubMed	PTHR44017:SF4	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4
P00057	Wnt signaling pathway	P01452	NFAT	PANTR|Ensembl=ENSPTRG00000008260|UniProtKB=H2QBD7	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	ISS	12015605	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00025	Hedgehog signaling pathway	P00682	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	7925653	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT1G59580|UniProtKB=Q39022	Mitogen-activated protein kinase 2	ISS	9836510	gi	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00021	FGF signaling pathway	P00642	MEK1-2	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IGI	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04392	P53 pathway feedback loops 1	G04684	Pirh-2	PANTR|Ensembl=ENSPTRG00000016170|UniProtKB=H2QPP6	Ring finger and CHY zinc finger domain containing 1	ISS	607680	OMIM	PTHR21319:SF20	RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1
P00034	Integrin signalling pathway	P00942	Fyn	MACMU|Ensembl=ENSMMUG00000017017|UniProtKB=F7FVL2	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05913	Enkephalin release	G06045	preproenkephalin	MOUSE|MGI=MGI=97535|UniProtKB=O35417	Proenkephalin-B	IC	131330	OMIM	PTHR11438:SF4	PROENKEPHALIN-B
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000004742|UniProtKB=H2Q5K1	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01199	Galpha	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04393	Ras Pathway	P04547	Ras	BOVIN|Ensembl=ENSBTAG00000009778|UniProtKB=E1BMX0	Uncharacterized protein	ISS	99084794	PubMed	PTHR24070:SF186	GTPASE KRAS
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	RAT|RGD=2345|UniProtKB=P04757	Neuronal acetylcholine receptor subunit alpha-3	IC	18005395	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	SCHPO|PomBase=SPCC1259.06|UniProtKB=O94706	Transcription initiation factor TFIID subunit 8	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00006	Apoptosis signaling pathway	P00260	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	IPI	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00007	Axon guidance mediated by semaphorins	P00333	RhoGEF	MOUSE|MGI=MGI=1353510|UniProtKB=Q61210	Rho guanine nucleotide exchange factor 1	ISS	12024019	PubMed	PTHR12673:SF122	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	18021322	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P02738	De novo purine biosynthesis	P02894	IMP cyclohydrolase	THEMA|EnsemblGenome=TM_1249|UniProtKB=Q9X0X6	Bifunctional purine biosynthesis protein PurH	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MONDO|Ensembl=ENSMODG00000024440|UniProtKB=F7DJJ2	Muscarinic acetylcholine receptor	ISS	91373358	PubMed	PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MOUSE|MGI=MGI=1336171|UniProtKB=Q9DAS9	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MACMU|Ensembl=ENSMMUG00000014597|UniProtKB=F6VAQ6	Glycogen synthase kinase-3 alpha	ISS	2164470	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00045	Notch signaling pathway	P01101	Su(H)	RAT|RGD=1310557|UniProtKB=F1LNW1	Protein Rbpj	ISS	8406481	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CIOIN|Ensembl=ENSCING00000001377|UniProtKB=F6SDC9	Uncharacterized protein	ISS			PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IGI	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00059	p53 pathway	P04633	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00007	Axon guidance mediated by semaphorins	P00340	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P05913	Enkephalin release	G06045	preproenkephalin	MOUSE|MGI=MGI=104629|UniProtKB=P22005	Proenkephalin-A	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00019	Endothelin signaling pathway	P00585	ECE1-3	RAT|RGD=620293|UniProtKB=P42893	Endothelin-converting enzyme 1	IGI	8034569	PubMed	PTHR11733:SF130	ENDOTHELIN-CONVERTING ENZYME 1
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	PANTR|Ensembl=ENSPTRG00000001791|UniProtKB=H2R8B2	Uncharacterized protein	ISS	12193720	PubMed	PTHR10845:SF32	REGULATOR OF G-PROTEIN SIGNALING 13
P00029	Huntington disease	P00807	Actin	PLAF7|EnsemblGenome=PFL2215w|UniProtKB=Q8I4X0	Actin-1	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	TAS	15572354	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=1306541|UniProtKB=D3ZVF3	Phosphoinositide-3-kinase, class 2, beta polypeptide (Predicted)	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	TAS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00054	Toll receptor signaling pathway	P01369	MKK1	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00048	PI3 kinase pathway	P01192	p110	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06849	Sos	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	RCA	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	IDA	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MOUSE|MGI=MGI=1339709|UniProtKB=P13541	Myosin-3	ISS	10938134	PubMed	PTHR13140:SF427	MYOSIN-3
P00034	Integrin signalling pathway	P00927	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00052	TGF-beta signaling pathway	P01292	RSmads	XENTR|Xenbase=XB-GENE-1018193|UniProtKB=Q6DIS7	Mothers against decapentaplegic homolog	ISS	12736218	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00019	Endothelin signaling pathway	P00587	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00186	FGFR-1	PANTR|Ensembl=ENSPTRG00000020176|UniProtKB=H2R210	Fibroblast growth factor receptor	ISS	1708247	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00006	Apoptosis signaling pathway	P00302	ATF	PANTR|Ensembl=ENSPTRG00000001962|UniProtKB=H2R845	Uncharacterized protein	ISS	11390664	PubMed	PTHR23351:SF23	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	XENTR|Xenbase=XB-GENE-977853|UniProtKB=F7EBE7	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00539	14-3-3	MOUSE|MGI=MGI=109484|UniProtKB=P63101	14-3-3 protein zeta/delta	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00633	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00018	EGF receptor signaling pathway	P00564	Rac	DICPU|Gene=DICPUDRAFT_168754|UniProtKB=F0ZQR3	Rac1B, RHO family GTPase	ISS	4757952	gi	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00029	Huntington disease	P00790	beta-Tubulin	STRPU|EnsemblGenome=SPU_016007|UniProtKB=W4YJP3	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Ensembl=ENSCAFG00000009967|UniProtKB=F1PGZ2	Muscarinic acetylcholine receptor	ISS			PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00010	B cell activation	P00392	I kappa B	HUMAN|HGNC=7797|UniProtKB=P25963	NF-kappa-B inhibitor alpha	ISS	10811867	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=1753|UniProtKB=P55290	Cadherin-13	IDA	8120095	PubMed	PTHR24027:SF80	CADHERIN-13
P00018	EGF receptor signaling pathway	P00546	GAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00047	PDGF signaling pathway	P01142	p90RSK	MACMU|Ensembl=ENSMMUG00000005210|UniProtKB=F7CM91	Uncharacterized protein	ISS			PTHR15508:SF2	RIBOSOMAL PROTEIN S6 KINASE DELTA-1
P05915	Opioid proenkephalin pathway	P05994	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00036	Interleukin signaling pathway	P00986	eNOS	PANTR|Ensembl=ENSPTRG00000019868|UniProtKB=H2QVM2	Nitric oxide synthase	ISS	22462730	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00948	Rho	DANRE|ZFIN=ZDB-GENE-040426-2150|UniProtKB=Q6NUX8	Rho-related GTP-binding protein RhoA-A	ISS	14871999	PubMed	PTHR24072:SF260	RHO-RELATED GTP-BINDING PROTEIN RHOA-A-RELATED
P05730	Endogenous cannabinoid signaling	P05746	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	PANTR|Ensembl=ENSPTRG00000015616|UniProtKB=H2QNQ5	SKI-like oncogene	ISS	10485843	PubMed	PTHR10005:SF3	SKI-LIKE PROTEIN
P00046	Oxidative stress response	P01129	JNK1/2	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00642	MEK1-2	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00010	B cell activation	P00401	jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00025	Hedgehog signaling pathway	P00692	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00022	General transcription by RNA polymerase I	P00651	TAF-IA	MACMU|Ensembl=ENSMMUG00000012470|UniProtKB=F7G0B2	Uncharacterized protein	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	12805548	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00018	EGF receptor signaling pathway	P00552	Ras	CHICK|Ensembl=ENSGALG00000006885|UniProtKB=P08642	GTPase HRas	ISS	3035212	PubMed	PTHR24070:SF385	GTPASE HRAS
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	HUMAN|HGNC=7160|UniProtKB=P50281	Matrix metalloproteinase-14	TAS	12834808	PubMed	PTHR10201:SF24	MATRIX METALLOPROTEINASE-14
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	10644715	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00011	Blood coagulation	P00411	PAI-1	BOVIN|Ensembl=ENSBTAG00000014465|UniProtKB=P13909	Plasminogen activator inhibitor 1	ISS	88329072	PubMed	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P04395	Vasopressin synthesis	P04593	Glycopeptide	BOVIN|Ensembl=ENSBTAG00000008026|UniProtKB=P01175	Oxytocin-neurophysin 1	IC	3768139	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00391	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00024	Glycolysis	P00676	Glyceraldehyde 3-phosphate dehydrogenase	RAT|RGD=2661|UniProtKB=P04797	Glyceraldehyde-3-phosphate dehydrogenase	RCA			PTHR10836:SF51	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHICK|Ensembl=ENSGALG00000014620|UniProtKB=F1N8P3	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00174	CD44 N-terminal fragment	MACMU|Ensembl=ENSMMUG00000004327|UniProtKB=F6ZDZ8	Uncharacterized protein	ISS	14871815	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00006	Apoptosis signaling pathway	P00272	ASK1	MOUSE|MGI=MGI=1346876|UniProtKB=O35099	Mitogen-activated protein kinase kinase kinase 5	ISS	11730323	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00046	Oxidative stress response	P01135	p38	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	4506785	gi	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00030	Hypoxia response via HIF activation	P00819	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	ISS	91056091	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00054	Toll receptor signaling pathway	P01375	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05914	Nicotine degradation	P05984	CYP2A6	HUMAN|HGNC=2610|UniProtKB=P11509	Cytochrome P450 2A6	TAS	10093988	PubMed	PTHR24300:SF293	CYTOCHROME P450 2A6-RELATED
P00019	Endothelin signaling pathway	P00577	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00045	Notch signaling pathway	P01111	LNXp80	HUMAN|HGNC=20421|UniProtKB=Q8N448	Ligand of Numb protein X 2	ISS			PTHR19964:SF33	LIGAND OF NUMB PROTEIN X 2
P00025	Hedgehog signaling pathway	P00682	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	IDA	91298951	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00896	Insulin IGF	CHICK|Gene=IGF2|UniProtKB=P33717	Insulin-like growth factor II	ISS	4504609	gi	PTHR11454:SF10	INSULIN-LIKE GROWTH FACTOR II
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	TAS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	MACMU|Ensembl=ENSMMUG00000005384|UniProtKB=F7GUL4	Suppressor of cytokine signaling 5	ISS	15032587	PubMed	PTHR44282:SF3	SUPPRESSOR OF CYTOKINE SIGNALING 5
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00053	T cell activation	P01312	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CAEEL|WormBase=WBGene00004039|UniProtKB=Q21754	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF147	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-2
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00774	Dynein complex	CANLF|Ensembl=ENSCAFG00000010384|UniProtKB=F1PUS6	Uncharacterized protein	ISS	9454836	PubMed	PTHR10676:SF310	DYNEIN HEAVY CHAIN 7, AXONEMAL
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000015599|UniProtKB=F1MIA2	Serine/threonine-protein kinase	ISS	11062248	PubMed	PTHR22968:SF12	SERINE/THREONINE-PROTEIN KINASE D2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	SCHPO|PomBase=SPBC1778.08c|UniProtKB=Q9Y7J4	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00048	PI3 kinase pathway	P01188	Gbetagamma	BRAFL|Gene=BRAFLDRAFT_220697|UniProtKB=C3ZSF0	Putative uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00021	FGF signaling pathway	P00641	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	18021322	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00012	Cadherin signaling pathway	P00470	F-actin	DROME|FlyBase=FBgn0000047|UniProtKB=P83967	Actin, indirect flight muscle	IC	10974003	PubMed	PTHR11937:SF368	ACTIN, INDIRECT FLIGHT MUSCLE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	PANTR|Ensembl=ENSPTRG00000001854|UniProtKB=H2Q0X1	Uncharacterized protein	ISS	SYT2_MOUSE	SPACC	PTHR10024:SF223	SYNAPTOTAGMIN-2
P00021	FGF signaling pathway	P00646	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	IPI	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00019	Endothelin signaling pathway	P00585	ECE1-3	PANTR|Ensembl=ENSPTRG00000000298|UniProtKB=H2R1S0	Endothelin converting enzyme 1	ISS	12464614	PubMed	PTHR11733:SF130	ENDOTHELIN-CONVERTING ENZYME 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	IDA	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00053	T cell activation	P01332	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00587	Raf-1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00048	PI3 kinase pathway	P01192	p110	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00474	Wnt	CAEBR|Gene=CBG03422|UniProtKB=A8WV10	Protein CBR-CWN-2	ISS	11266476	PubMed	PTHR12027:SF77	PROTEIN WNT-5
P04395	Vasopressin synthesis	P04596	Endo Peptidase	ANOGA|Gene=AgaP_AGAP009172|UniProtKB=Q7PVV8	AGAP009172-PA (Fragment)	IC	9695945	PubMed	PTHR42881:SF2	PROLYL ENDOPEPTIDASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	BACSU|EnsemblGenome=BSU22370|UniProtKB=P53001	Aspartate aminotransferase	ISS			PTHR11751:SF306	SUBFAMILY NOT NAMED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	176892	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00059	p53 pathway	P04626	GADD45	RAT|RGD=1311796|UniProtKB=Q9WTQ7	Growth arrest and DNA damage-inducible protein GADD45 gamma	IGI	10097101	PubMed	PTHR10411:SF4	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 GAMMA
P05731	GABA-B receptor II signaling	P05754	Ggamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01208	Hsp70	SCHPO|PomBase=SPCC1739.13|UniProtKB=O59855	Probable heat shock protein ssa2	IDA	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00048	PI3 kinase pathway	P01189	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	TAS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00029	Huntington disease	P00799	JNK-2	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	CAEEL|WormBase=WBGene00008095|UniProtKB=Q93372	Uncharacterized protein	ISS			PTHR24057:SF20	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	PANTR|Ensembl=ENSPTRG00000017441|UniProtKB=H2QRU7	Glutamate receptor, ionotropic, AMPA 1	ISS	12941441	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=12780|UniProtKB=P09544	Protein Wnt-2	TAS	11266476	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PHYIT|EnsemblGenome=PITG_15117|UniProtKB=D0NRP9	Actin-like protein	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IC	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00010	B cell activation	P00370	NFkappaB	MACMU|Ensembl=ENSMMUG00000002990|UniProtKB=F7GVV0	Uncharacterized protein	ISS	20151924	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00057	Wnt signaling pathway	P01461	FrzB	BOVIN|Ensembl=ENSBTAG00000010977|UniProtKB=Q95117	Secreted frizzled-related protein 3	ISS	9118218	PubMed	PTHR11309:SF97	SECRETED FRIZZLED-RELATED PROTEIN 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHICK|Gene=ACTG2|UniProtKB=P63270	Actin, gamma-enteric smooth muscle	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	RAT|RGD=61986|UniProtKB=P97711	G protein-coupled receptor kinase 6	IDA	8288567	PubMed	PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00941	Integrin alpha	MOUSE|MGI=MGI=104756|UniProtKB=B8JK39	Integrin alpha-9	IPI	3487386	PubMed	PTHR23220:SF69	INTEGRIN ALPHA-9
P00020	FAS signaling pathway	P00615	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	DROME|FlyBase=FBgn0011582|UniProtKB=P41596	Dopamine receptor 1	ISS	15328036	PubMed	PTHR43893:SF6	DOPAMINE RECEPTOR 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00046	Oxidative stress response	P01121	MKK3/6	CANLF|Ensembl=ENSCAFG00000010758|UniProtKB=E2R7W7	Uncharacterized protein	RCA			PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	DANRE|ZFIN=ZDB-GENE-030407-1|UniProtKB=F1QC27	Uncharacterized protein	ISS			PTHR11681:SF14	SUBFAMILY NOT NAMED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CRYNJ|EnsemblGenome=CNA04650|UniProtKB=Q5KP06	Actin	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00005	Angiogenesis	P00206	Wnt	HUMAN|HGNC=12774|UniProtKB=P04628	Proto-oncogene Wnt-1	IDA	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00226	Delta/Serrate	MACMU|Ensembl=ENSMMUG00000018116|UniProtKB=F7FGM9	Delta-like protein	ISS	10551863	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	HUMAN|HGNC=6148|UniProtKB=P20701	Integrin alpha-L	IDA	11163192	PubMed	PTHR23220:SF84	INTEGRIN ALPHA-L
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000022548|UniProtKB=F6Y9J9	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00006	Apoptosis signaling pathway	P00269	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	HUMAN|HGNC=1958|UniProtKB=P43681	Neuronal acetylcholine receptor subunit alpha-4	ISS	17597586	PubMed	PTHR18945:SF401	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00047	PDGF signaling pathway	P01173	STAT	BOVIN|Gene=STAT5B|UniProtKB=Q9TUM3	Signal transducer and activator of transcription 5B	ISS	20119183	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000000985|UniProtKB=F6VRS9	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	IC	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00047	PDGF signaling pathway	P01151	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	DROME|FlyBase=FBgn0265434|UniProtKB=Q99323	Myosin heavy chain, non-muscle	ISS	89264452	PubMed	PTHR13140:SF574	MYOSIN HEAVY CHAIN, NON-MUSCLE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P02721	ATP synthesis	P02798	Cyt C	RAT|RGD=1584748|UniProtKB=D4A5L9	Protein LOC679794	ISS	11836241	PubMed	PTHR11961:SF15	CYTOCHROME C
P00021	FGF signaling pathway	P00645	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	10540223	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000006495|UniProtKB=P11017	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00011	Blood coagulation	P00429	PN2	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	ISS	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00010	B cell activation	P00379	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00034	Integrin signalling pathway	P00916	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00025	Hedgehog signaling pathway	P00682	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05913	Enkephalin release	P05977	G-Protein (s)	DANRE|ZFIN=ZDB-GENE-070112-342|UniProtKB=A1L271	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00801	Fos protein	PANTR|Ensembl=ENSPTRG00000006553|UniProtKB=A5A6H0	C-fos	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00057	Wnt signaling pathway	P01458	Protein Kinase C	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	IDA	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06847	JNK1/2	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	RCA	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00019	Endothelin signaling pathway	P00589	Akt	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	IGI	12655147	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CANLF|Ensembl=ENSCAFG00000016020|UniProtKB=O18840	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000001583|UniProtKB=F7BBM1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	SCHPO|PomBase=SPBC8D2.01|UniProtKB=Q9URT9	Protein kinase gsk31	ISS	21361340	gi	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MOUSE|MGI=MGI=107813|UniProtKB=Q9ERD7	Tubulin beta-3 chain	ISS	9454836	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IGI	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	IDA	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02744	Fructose galactose metabolism	P02966	Hexokinase	RAT|RGD=2321830|UniProtKB=M0R3X7	Protein LOC100364027	RCA			PTHR19443:SF28	HEXOKINASE HKDC1-RELATED
P00040	Metabotropic glutamate receptor group II pathway	G01540	BDNF	CHICK|Ensembl=ENSGALG00000012163|UniProtKB=P25429	Brain-derived neurotrophic factor	ISS	11724916	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	ORNAN|Ensembl=ENSOANG00000000985|UniProtKB=F6XK44	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF147	REGULATOR OF G-PROTEIN SIGNALING 8
P00006	Apoptosis signaling pathway	P00302	ATF	PANTR|Ensembl=ENSPTRG00000012660|UniProtKB=H2QJ07	Activating transcription factor 2	ISS	10487205	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00036	Interleukin signaling pathway	P00990	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00255	Notch	RAT|RGD=3187|UniProtKB=Q07008	Neurogenic locus notch homolog protein 1	ISS	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00018	EGF receptor signaling pathway	P00551	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IGI	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00475	Frizzled	RAT|RGD=1560525|UniProtKB=Q498S8	Frizzled-8	ISS	11212302	PubMed	PTHR11309:SF90	FRIZZLED-8
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	HUMAN|HGNC=10436|UniProtKB=P23443	Ribosomal protein S6 kinase beta-1	ISS	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00047	PDGF signaling pathway	P01167	Ets	MONDO|Ensembl=ENSMODG00000004730|UniProtKB=F6Y1Z2	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00029	Huntington disease	P00777	CBP	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00048	PI3 kinase pathway	P01205	NOS	CANLF|Gene=NOS3|UniProtKB=Q9TUX8	Nitric oxide synthase, endothelial	ISS	22462730	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MACMU|Ensembl=ENSMMUG00000018790|UniProtKB=F6ZPM8	Serine/threonine-protein kinase receptor	ISS	11252892	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P00034	Integrin signalling pathway	P00907	ERK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IC			PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00019	Endothelin signaling pathway	P00568	PKC	CANAL|CGD=CAL0003231|UniProtKB=Q5ANK2	Protein kinase C	IGI	8813761	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	MOUSE|MGI=MGI=99779|UniProtKB=P49582	Neuronal acetylcholine receptor subunit alpha-7	ISS	85270494	PubMed	PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P00020	FAS signaling pathway	P00610	MKK4	CANLF|Ensembl=ENSCAFG00000017851|UniProtKB=F1PBB6	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	DICPU|Gene=DICPUDRAFT_85721|UniProtKB=F0Z6V2	Actin-related protein 2/3 complex subunit 4	ISS	5031595	gi	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00047	PDGF signaling pathway	P01153	GSK3	SCHPO|PomBase=SPAC1687.15|UniProtKB=Q10452	Protein kinase gsk3	ISS	12615961	PubMed	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P02772	Pyruvate metabolism	P03135	Phosphoenolpyruvate Carboxykinase	HUMAN|HGNC=8724|UniProtKB=P35558	Phosphoenolpyruvate carboxykinase, cytosolic [GTP]	ISS	8325643	PubMed	PTHR11561:SF1	PHOSPHOENOLPYRUVATE CARBOXYKINASE, CYTOSOLIC  GTP
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00056	VEGF signaling pathway	P01421	Rac	MACMU|Ensembl=ENSMMUG00000005364|UniProtKB=F6Y674	Proline-rich protein 5 isoform 1	ISS			PTHR32428:SF4	PROLINE-RICH PROTEIN 5
P00047	PDGF signaling pathway	P01156	PDGF receptor B	MACMU|Ensembl=ENSMMUG00000001153|UniProtKB=F6RQ55	Uncharacterized protein	ISS			PTHR15360:SF1	PLATELET-DERIVED GROWTH FACTOR RECEPTOR-LIKE PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00922	Collagen	CHICK|Ensembl=ENSGALG00000002509|UniProtKB=R4GM21	Uncharacterized protein	ISS	10778855	PubMed	PTHR24023:SF539	COLLAGEN ALPHA-2 V  CHAIN
P00029	Huntington disease	P00780	Microtubule	BATDJ|Gene=BATDEDRAFT_15405|UniProtKB=F4NUL6	Alpha-Beta tubulin	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	SCHPO|PomBase=SPAC6G9.11|UniProtKB=Q92356	Synaptobrevin homolog 1	ISS	14570579	PubMed	PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00025	Hedgehog signaling pathway	P00689	Patched	MOUSE|MGI=MGI=105373|UniProtKB=Q61115	Protein patched homolog 1	ISS	8647801	PubMed	PTHR10796:SF61	PROTEIN PATCHED HOMOLOG 1
P02771	Pyrimidine Metabolism	P03128	Dihydrouracil Dehydrogenase	PANTR|Ensembl=ENSPTRG00000000990|UniProtKB=H2PZG2	Dihydropyrimidine dehydrogenase	ISS	1512248	PubMed	PTHR43073:SF2	DIHYDROPYRIMIDINE DEHYDROGENASE  NADP +
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	YEAST|SGD=S000004747|UniProtKB=P38615	Serine/threonine-protein kinase RIM11/MSD1	IDA	12615961	PubMed	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	HUMAN|HGNC=10447|UniProtKB=P10301	Ras-related protein R-Ras	ISS	7997267	PubMed	PTHR24070:SF245	RAS-RELATED PROTEIN R-RAS
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ARATH|TAIR=AT1G59580|UniProtKB=Q39022	Mitogen-activated protein kinase 2	IDA			PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00053	T cell activation	P01322	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00589	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=97440|UniProtKB=P35377	Nociceptin receptor	IDA	11259498	PubMed	PTHR24229:SF11	NOCICEPTIN RECEPTOR
P00021	FGF signaling pathway	P00629	PP2A	BOVIN|Ensembl=ENSBTAG00000009245|UniProtKB=Q0P594	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05915	Opioid proenkephalin pathway	P05994	G-protein	PHYIT|EnsemblGenome=PITG_06376|UniProtKB=D0N4Q3	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta, putative	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04393	Ras Pathway	P04570	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05918	p38 MAPK pathway	P06023	MEF	BOVIN|Ensembl=ENSBTAG00000046545|UniProtKB=F1CYZ1	Myocyte enhancer factor 2D	ISS			PTHR11945:SF23	MYOCYTE-SPECIFIC ENHANCER FACTOR 2D
P00057	Wnt signaling pathway	P01438	PP2A	BOVIN|Ensembl=ENSBTAG00000005533|UniProtKB=F1N1S8	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CAEEL|WormBase=WBGene00004039|UniProtKB=Q21754	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF147	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000013316|UniProtKB=H2QK23	Uncharacterized protein	ISS	12562507	PubMed	PTHR24229:SF52	SOMATOSTATIN RECEPTOR TYPE 4
P00005	Angiogenesis	P00238	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	P01443	Phospholipase C	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IDA	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00019	Endothelin signaling pathway	P00589	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	IGI	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	RAT|RGD=2733|UniProtKB=P42260	Glutamate receptor ionotropic, kainate 2	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00046	Oxidative stress response	P01129	JNK1/2	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00048	PI3 kinase pathway	P01199	Galpha	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01423	p38MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00638	PLCgamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00047	PDGF signaling pathway	P01142	p90RSK	CANLF|Ensembl=ENSCAFG00000013171|UniProtKB=E2RP04	Uncharacterized protein	ISS	10480933	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00034	Integrin signalling pathway	P00921	PINCH	RAT|RGD=1560732|UniProtKB=C0KUC6	LIM and senescent cell antigen-like domains 1 isoform E	ISS	10022929	PubMed	PTHR24210:SF11	LIM AND SENESCENT CELL ANTIGEN-LIKE-CONTAINING DOMAIN PROTEIN 1-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00029	Huntington disease	P00797	p53	PANTR|Ensembl=ENSPTRG00000008703|UniProtKB=H2QC53	Cellular tumor antigen p53	ISS	11313951	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P04393	Ras Pathway	P04550	Ral	TAKRU|Ensembl=ENSTRUG00000006857|UniProtKB=H2SWP2	Uncharacterized protein	ISS	7687439	PubMed	PTHR24070:SF199	RAS-RELATED PROTEIN RAL-B
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00462	Casein kinase II	BOVIN|Ensembl=ENSBTAG00000008837|UniProtKB=P67868	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	SULSO|EnsemblGenome=SSO0201|UniProtKB=Q980S6	CTP synthase	ISS			PTHR11550:SF0	CTP SYNTHASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06786	ERK1/2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	RCA	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01457	GBeta	BRAFL|Gene=BRAFLDRAFT_220697|UniProtKB=C3ZSF0	Putative uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12805548	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00046	Oxidative stress response	P01135	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00053	T cell activation	P01312	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00012	Cadherin signaling pathway	P00467	alpha-catenin	RAT|RGD=1359485|UniProtKB=Q5U302	Catenin (Cadherin associated protein), alpha 1	ISS	10456847	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04393	Ras Pathway	P04556	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	CANLF|Gene=HTR2C|UniProtKB=Q60F97	5-hydroxytryptamine receptor 2C	ISS	11859080	PubMed	PTHR24247:SF32	5-HYDROXYTRYPTAMINE RECEPTOR 2C
P00029	Huntington disease	P00790	beta-Tubulin	LEIMA|EnsemblGenome=LmjF.21.1860|UniProtKB=Q4QBZ6	Beta tubulin	TAS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	MONDO|Ensembl=ENSMODG00000023174|UniProtKB=F7D7P2	Uncharacterized protein	ISS			PTHR23050:SF197	CALMODULIN-LIKE PROTEIN 3
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00010	B cell activation	P00373	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IGI	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00048	PI3 kinase pathway	P01192	p110	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04556	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	IDA	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00049	Parkinson disease	P01215	Syntaxin	HUMAN|HGNC=11442|UniProtKB=O15400	Syntaxin-7	IPI	10321247	PubMed	PTHR19957:SF90	SYNTAXIN-7
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00029	Huntington disease	P00805	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02738	De novo purine biosynthesis	P02898	Phosphoribosylformylglycinamide  synthase	DEIRA|EnsemblGenome=DR_0223|UniProtKB=Q9RXT3	Phosphoribosylformylglycinamidine synthase subunit PurQ	ISS			PTHR10099:SF1	PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00017	DNA replication	P00527	Histones	ORNAN|Ensembl=ENSOANG00000001482|UniProtKB=F7F1M9	Histone H3	ISS	12413958	PubMed	PTHR11426:SF179	HISTONE H3.3
P00018	EGF receptor signaling pathway	P00551	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00629	PP2A	RAT|RGD=1585097|UniProtKB=A0A0G2JZD1	Protein Ppp2r5c	ISS	10092233	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P00005	Angiogenesis	P00184	Src	BOVIN|Ensembl=ENSBTAG00000008938|UniProtKB=E1BIM8	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Ensembl=ENSBTAG00000037726|UniProtKB=P10895	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	10934033	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8689|UniProtKB=Q9Y5E5	Protocadherin beta-4	IDA	8120095	PubMed	PTHR24028:SF55	PROTOCADHERIN BETA-4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	ARATH|TAIR=AT2G31900|UniProtKB=F4IRU3	Myosin-12	IC			PTHR13140:SF270	MYOSIN-12
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	XENTR|Xenbase=XB-GENE-6035431|UniProtKB=F6RJ06	Uncharacterized protein	ISS			PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00047	PDGF signaling pathway	P01159	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	CANLF|Ensembl=ENSCAFG00000013966|UniProtKB=F1PJF3	Uncharacterized protein	ISS			PTHR11405:SF38	CARBAMOYL-PHOSPHATE SYNTHASE  AMMONIA , MITOCHONDRIAL
P00036	Interleukin signaling pathway	P00990	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00025	Hedgehog signaling pathway	P00682	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	ISS	2372396	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01181	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	ANOGA|EnsemblGenome=AGAP003405|UniProtKB=Q7QDK6	Adenylosuccinate synthetase	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00057	Wnt signaling pathway	P01465	Ggamma	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00023	General transcription regulation	P00666	TFIIE	YEAST|SGD=S000001770|UniProtKB=P36145	Transcription initiation factor IIE subunit beta	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ARATH|TAIR=AT2G42100|UniProtKB=Q8RYC2	Putative actin-5	IC	11889126	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00019	Endothelin signaling pathway	P00578	eNOS	HUMAN|HGNC=7876|UniProtKB=P29474	Nitric oxide synthase, endothelial	ISS	93055452	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00053	T cell activation	P01315	Calcineurin	PANTR|Ensembl=ENSPTRG00000002631|UniProtKB=H2Q237	Serine/threonine-protein phosphatase	ISS	7532676	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P05916	Opioid prodynorphin pathway	P06002	G-protein	ORNAN|Ensembl=ENSOANG00000003489|UniProtKB=F7FSE3	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01172	c-Myc	MACMU|Ensembl=ENSMMUG00000014601|UniProtKB=B8XIA5	Myc proto-oncogene protein	ISS	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01312	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00049	Parkinson disease	P01211	ERK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	IDA	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00029	Huntington disease	P00781	Dynactin	MACMU|Ensembl=ENSMMUG00000015610|UniProtKB=F6T5J5	Uncharacterized protein	ISS	9454836	PubMed	PTHR18916:SF40	DYNACTIN SUBUNIT 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02746	Heme biosynthesis	P02982	Protoheme IX farnesyl transferase	CAEEL|WormBase=WBGene00012895|UniProtKB=K8ES01	Protoheme IX farnesyltransferase, mitochondrial	ISS			PTHR43448:SF2	PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	BOVIN|Ensembl=ENSBTAG00000000231|UniProtKB=F1MCE7	Receptor protein serine/threonine kinase	ISS	10683140	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P00029	Huntington disease	P00801	Fos protein	PANTR|Ensembl=ENSPTRG00000006553|UniProtKB=A5A6H0	C-fos	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00023	General transcription regulation	P00660	RNA Polymerase II	ARATH|TAIR=AT2G15430|UniProtKB=Q39211	DNA-directed RNA polymerases II, IV and V subunit 3	ISS	2187864	PubMed	PTHR11800:SF2	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3
P00009	Axon guidance mediated by netrin	P00363	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00052	TGF-beta signaling pathway	P01286	TGFbeta	DANRE|ZFIN=ZDB-GENE-980526-474|UniProtKB=O93369	Bone morphogenetic protein 2	TAS	9759503	PubMed	PTHR11848:SF229	BONE MORPHOGENETIC PROTEIN 2
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	MOUSE|MGI=MGI=94925|UniProtKB=P30728	D(3) dopamine receptor	RCA	2039532	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00006	Apoptosis signaling pathway	P00274	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00557	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IGI	12660731	PubMed	PTHR10048:SF14	PI-3 KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00011	Blood coagulation	P00420	GP V	MACMU|Ensembl=ENSMMUG00000022431|UniProtKB=F6X4B0	Uncharacterized protein	ISS	4758460	gi	PTHR24373:SF144	PLATELET GLYCOPROTEIN V
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00048	PI3 kinase pathway	P01192	p110	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06959	CCKR signaling map	P07190	G34	HUMAN|HGNC=4164|UniProtKB=P01350	Gastrin	RCA	11181951	PubMed	PTHR19309:SF0	GASTRIN
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01199	Galpha	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	IC	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	ARATH|TAIR=AT3G22460|UniProtKB=Q9LJA0	Putative inactive cysteine synthase 2	ISS			PTHR10314:SF160	CYSTEINE SYNTHASE 1-RELATED
P00006	Apoptosis signaling pathway	P00291	MEKK1	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	ISS	12168099	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04455	beta-endorphin	MONDO|Ensembl=ENSMODG00000015853|UniProtKB=Q95J84	Proopiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BOVIN|Gene=ACTB|UniProtKB=P60712	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IDA	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00036	Interleukin signaling pathway	P00962	ELK	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	11279280	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	IDA	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04393	Ras Pathway	P04574	PLD	PANTR|Ensembl=ENSPTRG00000008610|UniProtKB=H2QBY9	Uncharacterized protein	ISS	15030398	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P04393	Ras Pathway	P04570	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01142	p90RSK	CANLF|Ensembl=ENSCAFG00000011590|UniProtKB=E2R7K9	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	TAS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06769	Gbeta	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	RCA	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00048	PI3 kinase pathway	P01188	Gbetagamma	EMENI|EnsemblGenome=CADANIAG00002670|UniProtKB=Q5BH99	G-protein beta subunit [Source:UniProtKB/TrEMBLAcc:O74214]	IC	10523303	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	DANRE|ZFIN=ZDB-GENE-030407-2|UniProtKB=F8W5D0	Uncharacterized protein (Fragment)	ISS			PTHR11681:SF13	SUBFAMILY NOT NAMED
P00015	Circadian clock system	P00502	Casein kinase I	DROME|FlyBase=FBgn0002413|UniProtKB=O76324	Discs overgrown protein kinase	IDA	14712927	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	ISS			PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P05914	Nicotine degradation	P05981	INMT	MACMU|Ensembl=ENSMMUG00000011760|UniProtKB=F7HSK5	Indolethylamine N-methyltransferase isoform 1	ISS			PTHR10867:SF6	INDOLETHYLAMINE N-METHYLTRANSFERASE-RELATED
P00034	Integrin signalling pathway	P00927	Rac	DROME|FlyBase=FBgn0010333|UniProtKB=P40792	Ras-related protein Rac1	IGI	12932731	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02738	De novo purine biosynthesis	P02907	dADP kinase	ANOGA|EnsemblGenome=AGAP007120|UniProtKB=Q7QIX6	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00013	Cell cycle	P00483	Cyclin E	RAT|RGD=2294|UniProtKB=P39949	G1/S-specific cyclin-E1	ISS	12628165	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00245	Rac	MOUSE|MGI=MGI=2445003|UniProtKB=Q5FWK3	Rho GTPase-activating protein 1	ISS	14724572	PubMed	PTHR23176:SF28	RHO GTPASE-ACTIVATING PROTEIN 1
P00005	Angiogenesis	P00217	STAT3	MACMU|Ensembl=ENSMMUG00000010707|UniProtKB=F7G8G5	Signal transducer and activator of transcription	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=30035|UniProtKB=Q8WYR1	Phosphoinositide 3-kinase regulatory subunit 5	ISS	12507995	PubMed	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	IXOSC|EnsemblGenome=ISCW024111|UniProtKB=B7PBG2	Actin, putative (Fragment)	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P06215	MYO signaling pathway	P06311	MED	DROME|FlyBase=FBgn0011648|UniProtKB=P42003	Protein mothers against dpp	RCA			PTHR13703:SF40	PROTEIN MOTHERS AGAINST DPP
P05915	Opioid proenkephalin pathway	P05994	G-protein	EMENI|EnsemblGenome=CADANIAG00002670|UniProtKB=Q5BH99	G-protein beta subunit [Source:UniProtKB/TrEMBLAcc:O74214]	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06777	NFAT	MOUSE|MGI=MGI=1920431|UniProtKB=Q8K120	Nuclear factor of activated T-cells, cytoplasmic 4	RCA	12787506	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00012	Cadherin signaling pathway	P00463	betacatenin	PANTR|Ensembl=ENSPTRG00000023062|UniProtKB=H2R2U1	Catenin (Cadherin-associated protein), beta 1, 88kDa	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00005	Angiogenesis	P00217	STAT3	MACMU|Ensembl=ENSMMUG00000010707|UniProtKB=F7G8G5	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00057	Wnt signaling pathway	P01457	GBeta	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IDA	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	TAS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04398	p53 pathway feedback loops 2	P04657	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	CAEBR|Gene=CBG14224|UniProtKB=A8XJJ7	Protein CBR-GLT-1	ISS	94365697	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P02728	Arginine biosynthesis	P02846	Ornithine carbamoyl transferase	NEUCR|EnsemblGenome=EFNCRG00000001685|UniProtKB=Q1K5I2	Ornithine carbamoyltransferase	ISS			PTHR11405:SF1	ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL
P00019	Endothelin signaling pathway	P00589	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IGI	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	DANRE|ZFIN=ZDB-GENE-000330-9|UniProtKB=Q90ZE4	Presenilin-2	IDA	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00036	Interleukin signaling pathway	P00974	Receptor subunit beta	CHICK|Ensembl=ENSGALG00000015941|UniProtKB=F1P5Q1	Uncharacterized protein	ISS	10077530	PubMed	PTHR20859:SF50	INTERLEUKIN-10 RECEPTOR SUBUNIT BETA
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=1563261|UniProtKB=D4A4I3	Protein Pik3r5	ISS			PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00010	B cell activation	P00385	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	20010089	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	BRAFL|Gene=BRAFLDRAFT_220697|UniProtKB=C3ZSF0	Putative uncharacterized protein	ISS	9740024	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00549	EGF	HUMAN|HGNC=7999|UniProtKB=P56975	Pro-neuregulin-3, membrane-bound isoform	RCA			PTHR11100:SF18	PRO-NEUREGULIN-3, MEMBRANE-BOUND ISOFORM
P00006	Apoptosis signaling pathway	P00269	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	TAS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04398	p53 pathway feedback loops 2	P04657	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	ARATH|TAIR=AT5G61210|UniProtKB=Q9S7P9	SNAP25 homologous protein SNAP33	IC			PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00053	T cell activation	P01306	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	MACMU|Ensembl=ENSMMUG00000009287|UniProtKB=F7H3T9	Glutamate receptor 1 isoform 1	ISS	12941441	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P05731	GABA-B receptor II signaling	P05755	Gbeta	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00705	Gsalpha	HUMAN|HGNC=4388|UniProtKB=P38405	Guanine nucleotide-binding protein G(olf) subunit alpha	IDA	2106672	PubMed	PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00056	VEGF signaling pathway	P01425	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00237	FRP	HUMAN|HGNC=4041|UniProtKB=Q9NPG1	Frizzled-3	IC	8717036	PubMed	PTHR11309:SF22	FRIZZLED-3
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00049	Parkinson disease	P01208	Hsp70	ORYSJ|EnsemblGenome=OS05G0460000|UniProtKB=Q6L509	Os05g0460000 protein	IDA	12150907	PubMed	PTHR19375:SF255	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 37C-RELATED
P05915	Opioid proenkephalin pathway	P05994	G-protein	ANOGA|EnsemblGenome=AGAP005912|UniProtKB=Q7Q6D3	AGAP005912-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	HUMAN|HGNC=7174|UniProtKB=P09237	Matrilysin	IEP	12834808	PubMed	PTHR10201:SF143	MATRILYSIN
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01444	Wnt	DANRE|ZFIN=ZDB-GENE-980526-249|UniProtKB=Q9I9I2	Protein Wnt	IDA	8717036	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	CAEBR|Gene=CBG01097|UniProtKB=A8WPJ8	Protein CBR-CMD-1	ISS	7514101	PubMed	PTHR23050:SF236	CALMODULIN
P00029	Huntington disease	P00778	NMDA receptor	ANOGA|EnsemblGenome=AGAP001478|UniProtKB=Q7PXM3	AGAP001478-PA	IDA	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00021	FGF signaling pathway	P00625	MKK3,6	CHICK|Ensembl=ENSGALG00000004735|UniProtKB=F1NHE1	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00010	B cell activation	P00376	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00638	PLCgamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	IDA	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P05913	Enkephalin release	P05972	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	ORNAN|Ensembl=ENSOANG00000004058|UniProtKB=F6TYP9	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00005	Angiogenesis	P00221	JNK1	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01157	MAPKAPK2	PANTR|Ensembl=ENSPTRG00000001915|UniProtKB=H2Q104	Mitogen-activated protein kinase-activated protein kinase 2	ISS	7923354	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00010	B cell activation	P00374	Lyn	ORNAN|Ensembl=ENSOANG00000005501|UniProtKB=F6X6I5	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00036	Interleukin signaling pathway	P00973	PKB	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	XENTR|Xenbase=XB-GENE-479707|UniProtKB=F6QAW3	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF126	FRIZZLED-5
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ORYSJ|EnsemblGenome=OS05G0106600|UniProtKB=Q65XH8	Os05g0106600 protein	IDA	10974003	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	IDA	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	MACMU|Ensembl=ENSMMUG00000006512|UniProtKB=F7H6S1	Mitogen-activated protein kinase kinase kinase 7 isoform B	ISS	10683140	PubMed	PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	NEUCR|EnsemblGenome=EFNCRG00000000159|UniProtKB=F5HH30	Guanine nucleotide-binding protein beta subunit	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	XENTR|Xenbase=XB-GENE-491938|UniProtKB=Q6DIV8	Actin, alpha 1, skeletal muscle	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00036	Interleukin signaling pathway	P00967	c-fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IC	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00254	GTPase	RAT|RGD=621309|UniProtKB=P62747	Rho-related GTP-binding protein RhoB	ISS	13679859	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00045	Notch signaling pathway	P01114	Ntm	RAT|RGD=3187|UniProtKB=Q07008	Neurogenic locus notch homolog protein 1	IEP	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00047	PDGF signaling pathway	P01160	IP3 receptor	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	HUMAN|HGNC=7568|UniProtKB=P35580	Myosin-10	ISS	89264452	PubMed	PTHR13140:SF328	MYOSIN-10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	RAT|RGD=620027|UniProtKB=P08911	Muscarinic acetylcholine receptor M5	IDA	12181435	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00006	Apoptosis signaling pathway	P00274	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00846	JAK	MONDO|Ensembl=ENSMODG00000015373|UniProtKB=F6WH53	Tyrosine-protein kinase	ISS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	RCA	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00313	IKK	CANLF|Ensembl=ENSCAFG00000009588|UniProtKB=E2RNA9	Uncharacterized protein	ISS	14499113	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00053	T cell activation	P01306	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=1339967|UniProtKB=B1AR69	Protein Myh13	IC	89264452	PubMed	PTHR13140:SF504	MYOSIN-13
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00012	Cadherin signaling pathway	P00474	Wnt	RAT|RGD=621346|UniProtKB=Q2IBD1	Protein Wnt	IDA	11266476	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P05915	Opioid proenkephalin pathway	P05994	G-protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	10799299	PubMed	PTHR10048:SF14	PI-3 KINASE
P00053	T cell activation	P01318	PKC-theta	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00046	Oxidative stress response	P01135	p38	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	TAS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P02782	Triacylglycerol metabolism	P03205	Triacylglycerol lipase	DROME|FlyBase=FBgn0034491|UniProtKB=Q7JR83	Hormone-sensitive lipase ortholog, isoform A	ISS			PTHR23025:SF3	HORMONE-SENSITIVE LIPASE
P00012	Cadherin signaling pathway	P00474	Wnt	MACMU|Ensembl=ENSMMUG00000022937|UniProtKB=F6U717	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	MOUSE|MGI=MGI=96281|UniProtKB=P34968	5-hydroxytryptamine receptor 2C	ISS	12441358	PubMed	PTHR24247:SF32	5-HYDROXYTRYPTAMINE RECEPTOR 2C
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	14564011	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00029	Huntington disease	P00777	CBP	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IDA	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00036	Interleukin signaling pathway	P00965	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	CHICK|Gene=JUN|UniProtKB=P18870	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00057	Wnt signaling pathway	P01437	TCF	CHICK|Ensembl=ENSGALG00000010529|UniProtKB=O93345	Lymphiod enhancer binding factor 1	IDA	11266476	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00005	Angiogenesis	P00218	STAT1	DANRE|ZFIN=ZDB-GENE-980526-499|UniProtKB=Q6P943	Signal transducer and activator of transcription	ISS	10417824	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IC	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00021	FGF signaling pathway	P00642	MEK1-2	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00030	Hypoxia response via HIF activation	P00817	TOR	MOUSE|MGI=MGI=1928394|UniProtKB=Q9JLN9	Serine/threonine-protein kinase mTOR	ISS	7518356	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00021	FGF signaling pathway	P00641	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IGI	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04393	Ras Pathway	P04556	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00010	B cell activation	P00398	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00009	Axon guidance mediated by netrin	P00363	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	XENTR|Ensembl=ENSXETG00000030140|UniProtKB=F7EP58	Uncharacterized protein (Fragment)	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00029	Huntington disease	P00798	Clathrin	HUMAN|HGNC=2091|UniProtKB=P09497	Clathrin light chain B	ISS	11889126	PubMed	PTHR10639:SF2	CLATHRIN LIGHT CHAIN B
P00047	PDGF signaling pathway	P01160	IP3 receptor	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P02754	Methylcitrate cycle	P03028	Aconitase	METAC|EnsemblGenome=MA_0250|UniProtKB=Q8TU24	Aconitate hydratase	ISS			PTHR11670:SF1	ACONITATE HYDRATASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02775	Salvage pyrimidine ribonucleotides	P03150	Uridine kinase	HALSA|EnsemblGenome=VNG_1219G|UniProtKB=Q9HQC9	Uridine kinase	ISS			PTHR10285:SF6	ATP-DEPENDENT KINASE TDA10-RELATED
P00004	Alzheimer disease-presenilin pathway	P00145	CD44	CHICK|Ensembl=ENSGALG00000007849|UniProtKB=F1NL98	Uncharacterized protein	IDA	14871815	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	RCA	1319556	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00034	Integrin signalling pathway	P00941	Integrin alpha	RAT|RGD=1311191|UniProtKB=D3ZN51	Protein Itga9	ISS	10209034	PubMed	PTHR23220:SF69	INTEGRIN ALPHA-9
P00019	Endothelin signaling pathway	P00566	ERK	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00628	JNK1-3	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	HUMAN|HGNC=6698|UniProtKB=O75581	Low-density lipoprotein receptor-related protein 6	IDA	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00375	Calmodulin	BOVIN|Ensembl=ENSBTAG00000001575|UniProtKB=F1N6C0	Uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF311	CALMODULIN
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P02772	Pyruvate metabolism	P03133	Pyruvate Dehydrogenase	HUMAN|HGNC=8807|UniProtKB=P29803	Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial	RCA			PTHR11516:SF27	PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA, TESTIS-SPECIFIC FORM, MITOCHONDRIAL
P00020	FAS signaling pathway	P00610	MKK4	PANTR|Ensembl=ENSPTRG00000008783|UniProtKB=H2QCA7	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00034	Integrin signalling pathway	P00928	alpha actinin	DANRE|ZFIN=ZDB-GENE-081113-4|UniProtKB=B8JHU4	Actn1 isoform b	ISS	2116421	PubMed	PTHR43947:SF3	ALPHA-ACTININ-1
P00059	p53 pathway	P04633	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00009	Axon guidance mediated by netrin	P00366	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12676940	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04393	Ras Pathway	P04557	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IDA	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02746	Heme biosynthesis	P02982	Protoheme IX farnesyl transferase	PSEAE|EnsemblGenome=PA1321|UniProtKB=Q9I423	Protoheme IX farnesyltransferase 2	ISS			PTHR43448:SF1	PROTOHEME IX FARNESYLTRANSFERASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	TAS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	YEAST|SGD=S000003700|UniProtKB=P06244	cAMP-dependent protein kinase type 1	ISS	89107990	PubMed	PTHR24353:SF73	CAMP-DEPENDENT PROTEIN KINASE TYPE 1-RELATED
P00053	T cell activation	P01331	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00049	Parkinson disease	P01238	14-3-3	EMENI|EnsemblGenome=CADANIAG00005943|UniProtKB=Q5B4M9	1433_TRIHA 14-3-3 PROTEIN HOMOLOG (TH1433)	IDA	22017897	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P02753	Methionine biosynthesis	P03024	Homocysteine transmethylase	STRCO|Gene=CAC18788|UniProtKB=Q9EWH3	Putative methionine synthase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	HUMAN|HGNC=4586|UniProtKB=Q13224	Glutamate receptor ionotropic, NMDA 2B	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IPI	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00964	p90RSK	BOVIN|Ensembl=ENSBTAG00000017639|UniProtKB=F1MZW8	Ribosomal protein S6 kinase	ISS	2779569	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	CHICK|Ensembl=ENSGALG00000003157|UniProtKB=E1C523	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF358	MYOSIN-7B
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	ANOGA|EnsemblGenome=AGAP009591|UniProtKB=Q7Q1X2	AGAP009591-PA (Fragment)	IC			PTHR11699:SF190	10-FORMYLTETRAHYDROFOLATE DEHYDROGENASE
P00014	Cholesterol biosynthesis	P00492	Mevalonate kinase	HUMAN|HGNC=7530|UniProtKB=Q03426	Mevalonate kinase	IDA	9392419	PubMed	PTHR43290:SF2	MEVALONATE KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00589	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	NAS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PUCGT|EnsemblGenome=PGTG_05488|UniProtKB=E3K4I1	Actin	IC	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	P01438	PP2A	ORNAN|Ensembl=ENSOANG00000009097|UniProtKB=F7G755	Uncharacterized protein	ISS	8703017	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	BOVIN|Ensembl=ENSBTAG00000018881|UniProtKB=E1BGL9	Uncharacterized protein	ISS			PTHR10024:SF45	SYNAPTOTAGMIN-6
P00053	T cell activation	P01318	PKC-theta	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00018	EGF receptor signaling pathway	P00560	Raf-1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	TAS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00029	Huntington disease	P00778	NMDA receptor	CHICK|Ensembl=ENSGALG00000011809|UniProtKB=F1NMB0	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	CHICK|Ensembl=ENSGALG00000011809|UniProtKB=F1NMB0	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05912	Dopamine receptor mediated signaling pathway	P05957	K+ channel	HUMAN|HGNC=6278|UniProtKB=O14649	Potassium channel subfamily K member 3	ISS	11875121	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P05912	Dopamine receptor mediated signaling pathway	P05963	MAO	MOUSE|MGI=MGI=96915|UniProtKB=Q64133	Amine oxidase [flavin-containing] A	ISS	8602220	PubMed	PTHR43563:SF3	AMINE OXIDASE  FLAVIN-CONTAINING  A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IDA	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P06664	Gonadotropin-releasing hormone receptor pathway	P06740	BMPR-IA/IB/II	MOUSE|MGI=MGI=1338938|UniProtKB=P36895	Bone morphogenetic protein receptor type-1A	RCA	10683140	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	PANTR|Ensembl=ENSPTRG00000006342|UniProtKB=H2Q8A8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IDA	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04395	Vasopressin synthesis	P04596	Endo Peptidase	MACMU|Ensembl=ENSMMUG00000013483|UniProtKB=F6ZLE6	Prolyl endopeptidase	ISS	9695945	PubMed	PTHR42881:SF2	PROLYL ENDOPEPTIDASE
P00018	EGF receptor signaling pathway	P00546	GAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	IGI	2842690	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00012	Cadherin signaling pathway	P00471	Cadherin	BOVIN|Ensembl=ENSBTAG00000017349|UniProtKB=A5D7F4	PCDHGC3 protein	ISS	8120095	PubMed	PTHR24028:SF70	PROTOCADHERIN GAMMA-C3
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	YEAST|SGD=S000004424|UniProtKB=P50095	Inosine-5'-monophosphate dehydrogenase 3	ISS			PTHR11911:SF111	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE
P04395	Vasopressin synthesis	P04589	Signal Peptidase	ARATH|TAIR=AT1G52600|UniProtKB=Q9SSR2	Signal peptidase I	IC	2092035	PubMed	PTHR10806:SF16	SIGNAL PEPTIDASE I
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	DANRE|ZFIN=ZDB-GENE-991123-5|UniProtKB=F1QZW1	Uncharacterized protein	ISS			PTHR13140:SF344	MYOSIN-7
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	ARATH|TAIR=AT5G54280|UniProtKB=F4K0A6	Myosin-2	IC			PTHR13140:SF702	MYOSIN-2-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00747	Rhodopsin	ANOGA|EnsemblGenome=AGAP012982|UniProtKB=F5HMY2	AGAP012982-PA	ISS	1634520	PubMed	PTHR24240:SF85	OPSIN RH1-RELATED
P00029	Huntington disease	P00780	Microtubule	GIAIC|EnsemblGenome=GL50803_101291|UniProtKB=A8BEI6	Beta tubulin	IDA	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00037	Ionotropic glutamate receptor pathway	P01026	KA	ORNAN|Ensembl=ENSOANG00000002061|UniProtKB=F7ANC6	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	XENTR|Xenbase=XB-GENE-961282|UniProtKB=Q6DF43	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00046	Oxidative stress response	P01134	cPLA2	MONDO|Ensembl=ENSMODG00000011791|UniProtKB=F7CBU9	Phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04393	Ras Pathway	P04546	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00049	Parkinson disease	P01208	Hsp70	CANLF|Ensembl=ENSCAFG00000020196|UniProtKB=F1PIC7	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00046	Oxidative stress response	P01122	TRX	DROME|FlyBase=FBgn0040070|UniProtKB=Q9V429	Thioredoxin-2	TAS	12115731	PubMed	PTHR10438:SF359	THIOREDOXIN
P05913	Enkephalin release	P05977	G-Protein (s)	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008422|UniProtKB=F6VUT7	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00047	PDGF signaling pathway	P01161	Raf	TAKRU|Ensembl=ENSTRUG00000011625|UniProtKB=H2TXG3	Uncharacterized protein	ISS	3043188	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00057	Wnt signaling pathway	P01457	GBeta	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00589	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS			PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P02723	Adenine and hypoxanthine salvage pathway	P02811	Adenosine deaminase	STRCO|EnsemblGenome=CAB42949|UniProtKB=Q9X7T2	Adenosine deaminase 2	ISS			PTHR11409:SF43	ADENOSINE DEAMINASE
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00021	FGF signaling pathway	P00633	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00012	Cadherin signaling pathway	P00477	GSK3beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	CHICK|Ensembl=ENSGALG00000008512|UniProtKB=F1P0S6	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MOUSE|MGI=MGI=88398|UniProtKB=Q9ERZ3	Muscarinic acetylcholine receptor M3	IDA	8100450	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00023	General transcription regulation	P00662	TFIIA complex	HUMAN|HGNC=30727|UniProtKB=Q9UNN4	TFIIA-alpha and beta-like factor	ISS			PTHR12694:SF9	PROTEIN STON1-GTF2A1L-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00021	FGF signaling pathway	P00625	MKK3,6	MONDO|Ensembl=ENSMODG00000001404|UniProtKB=F7BD74	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	G04714	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	MOUSE|MGI=MGI=96539|UniProtKB=P43431	Interleukin-12 subunit alpha	TAS	8557982	PubMed	PTHR45311:SF1	INTERLEUKIN-12 SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01161	Raf	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00005	Angiogenesis	P00234	Grb2	BOVIN|Ensembl=ENSBTAG00000003707|UniProtKB=A6QLK6	GRB2-related adapter protein	ISS			PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P00005	Angiogenesis	P00199	JNKK1	CHICK|Ensembl=ENSGALG00000001001|UniProtKB=F1P3T1	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00018	EGF receptor signaling pathway	P00564	Rac	DROME|FlyBase=FBgn0014011|UniProtKB=P48554	Ras-related protein Rac2	ISS	12588856	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT1G59580|UniProtKB=Q39022	Mitogen-activated protein kinase 2	IDA	176948	OMIM	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00034	Integrin signalling pathway	P00929	C3G	HUMAN|HGNC=4568|UniProtKB=Q13905	Rap guanine nucleotide exchange factor 1	IPI	10777617	PubMed	PTHR23113:SF224	RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00048	PI3 kinase pathway	P01185	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02751	Lysine biosynthesis	P03007	Diaminopimelate decarboxylase	STRCO|Gene=CAB55672|UniProtKB=Q9RL03	Putative decarboxylase	ISS			PTHR43727:SF3	SUBFAMILY NOT NAMED
P00053	T cell activation	P01337	B7	BOVIN|Ensembl=ENSBTAG00000018059|UniProtKB=O46405	CD80 anitgen (Fragment)	IDA	1650475	PubMed	PTHR25466:SF4	T-LYMPHOCYTE ACTIVATION ANTIGEN CD80
P00029	Huntington disease	P00774	Dynein complex	ANOGA|EnsemblGenome=AGAP000723|UniProtKB=Q7QEC0	AGAP000723-PA	IPI	9454836	PubMed	PTHR12688:SF0	DYNEIN LIGHT INTERMEDIATE CHAIN, ISOFORM A
P00021	FGF signaling pathway	P00627	ERK1-2	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00036	Interleukin signaling pathway	P00996	STAT	MACMU|Ensembl=ENSMMUG00000005617|UniProtKB=F6WDY6	Signal transducer and activator of transcription	ISS	94255416	PubMed	PTHR11801:SF19	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 4
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	PANTR|Ensembl=ENSPTRG00000004215|UniProtKB=H2Q4M7	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF143	MATRILYSIN
P02741	Flavin biosynthesis	P02939	Lumazine synthase	ECOLI|EcoGene=EG11322|UniProtKB=P61714	6,7-dimethyl-8-ribityllumazine synthase	ISS			PTHR21058:SF0	6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04395	Vasopressin synthesis	P04590	Vasopressin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00035	Interferon-gamma signaling pathway	P00960	PTP	HUMAN|HGNC=9658|UniProtKB=P29350	Tyrosine-protein phosphatase non-receptor type 6	TAS	14525967	PubMed	PTHR19134:SF65	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 6
P05730	Endogenous cannabinoid signaling	P05751	Galpha	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CANAL|CGD=CAL0064759|UniProtKB=Q5AKX0	Uncharacterized protein	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00049	Parkinson disease	P01208	Hsp70	BOVIN|Ensembl=ENSBTAG00000025442|UniProtKB=P0CB32	Heat shock 70 kDa protein 1-like	ISS	12150907	PubMed	PTHR19375:SF210	HEAT SHOCK 70 KDA PROTEIN 1-LIKE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04393	Ras Pathway	P04559	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	20264070	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04393	Ras Pathway	P04558	p38	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	IDA	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IGI	14526383	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	IDA	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00053	T cell activation	P01306	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00107	kinesin	RAT|RGD=621411|UniProtKB=P37285	Kinesin light chain 1	ISS	11740561	PubMed	PTHR19959:SF203	KINESIN LIGHT CHAIN 1
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IGI	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	MOUSE|MGI=MGI=1919558|UniProtKB=Q8CFK2	Transcription factor IIIB 90 kDa subunit	ISS			PTHR11618:SF4	TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT
P00049	Parkinson disease	P01213	Cyclin E	DANRE|ZFIN=ZDB-GENE-980526-168|UniProtKB=P47794	G1/S-specific cyclin-E1	IDA	18858511	gi	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CAEBR|Gene=CBG15043|UniProtKB=A8XL96	Protein CBG15043	ISS			PTHR13140:SF388	COILED-COIL DOMAIN-CONTAINING PROTEIN 171
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	P01471	alpha-catenin	HUMAN|HGNC=2509|UniProtKB=P35221	Catenin alpha-1	IDA	1768802	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00021	FGF signaling pathway	P00633	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00049	Parkinson disease	P01215	Syntaxin	BOVIN|Ensembl=ENSBTAG00000017139|UniProtKB=Q3ZBT5	Syntaxin-7	ISS	14570579	PubMed	PTHR19957:SF90	SYNTAXIN-7
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00034	Integrin signalling pathway	P00924	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00045	Notch signaling pathway	G01541	E(spl)-C genes	DANRE|ZFIN=ZDB-GENE-011213-1|UniProtKB=Q9DF41	BHLH-WRPW transcription factor	TAS	14973298	PubMed	PTHR10985:SF125	TRANSCRIPTION FACTOR HES-4
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04674	Mdm2	PANTR|Ensembl=ENSPTRG00000001889|UniProtKB=H2R875	Mdm4 p53 binding protein homolog	ISS			PTHR13844:SF20	PROTEIN MDM4
P00021	FGF signaling pathway	P00634	MEKK1-5	RAT|RGD=620966|UniProtKB=Q62925	Mitogen-activated protein kinase kinase kinase 1	IGI	8940199	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00039	Metabotropic glutamate receptor group III pathway	P01043	AC	RAT|RGD=708450|UniProtKB=Q9Z286	Adenylate cyclase type 10	IC	9874775	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00056	VEGF signaling pathway	P01417	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00012	Cadherin signaling pathway	P00467	alpha-catenin	DANRE|Ensembl=ENSDARG00000024785|UniProtKB=B7ZC77	Catenin alpha-2	ISS	9362521	PubMed	PTHR18914:SF29	CATENIN ALPHA-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00057	Wnt signaling pathway	P01447	Dishevelled	CAEEL|WormBase=WBGene00001102|UniProtKB=Q18239	DiSHevelled related	ISS	7906389	PubMed	PTHR10878:SF25	SEGMENT POLARITY PROTEIN DISHEVELLED
P00012	Cadherin signaling pathway	P00470	F-actin	DANRE|ZFIN=ZDB-GENE-050417-267|UniProtKB=F1QUN8	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF263	ACTIN
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	CANLF|Ensembl=ENSCAFG00000001310|UniProtKB=Q0ZAQ8	Peroxisome proliferator-activated receptor delta	ISS	12356903	PubMed	PTHR24082:SF15	PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DELTA
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00586	Gq	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	PANTR|Ensembl=ENSPTRG00000023608|UniProtKB=H2QZZ2	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00551	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01132	c-jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01062	mGluR1	RAT|RGD=2742|UniProtKB=P23385	Metabotropic glutamate receptor 1	ISS	12488551	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00034	Integrin signalling pathway	P00936	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	IPI	96320556	PubMed	PTHR10048:SF14	PI-3 KINASE
P00009	Axon guidance mediated by netrin	P00359	NFAT	CANLF|Ensembl=ENSCAFG00000011625|UniProtKB=F1PDD9	Uncharacterized protein	ISS	12787506	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00029	Huntington disease	P00811	Arp2/3 complex	ORNAN|Ensembl=ENSOANG00000007724|UniProtKB=F6QTB5	Uncharacterized protein	ISS	12932731	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P05917	Opioid proopiomelanocortin pathway	P06011	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	TAS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00004	Alzheimer disease-presenilin pathway	P00165	E-cadherin N-terminal fragment	XENTR|Xenbase=XB-GENE-482277|UniProtKB=F6QAX3	Uncharacterized protein	ISS	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P05731	GABA-B receptor II signaling	P05760	AC	PANTR|Ensembl=ENSPTRG00000006216|UniProtKB=H2Q832	Adenylate cyclase 4	ISS	9870949	PubMed	PTHR11920:SF286	ADENYLATE CYCLASE TYPE 4
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P04393	Ras Pathway	P04557	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IDA	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	MONDO|Ensembl=ENSMODG00000012761|UniProtKB=F6SJA3	Tyrosine-protein kinase receptor (Fragment)	ISS	249616	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05977	G-Protein (s)	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	RAT|RGD=1308730|UniProtKB=D3ZXD9	Matrix metalloproteinase 20 (Enamelysin) (Predicted)	ISS	12834808	PubMed	PTHR10201:SF125	MATRIX METALLOPROTEINASE-20
P04373	5HT1 type receptor mediated signaling pathway	P04407	K+ channel	BOVIN|Ensembl=ENSBTAG00000047488|UniProtKB=G3N1D1	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	CANLF|Ensembl=ENSCAFG00000004381|UniProtKB=J9JH96	Uncharacterized protein	ISS	14614461	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000025373|UniProtKB=F6ZZG9	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P04398	p53 pathway feedback loops 2	P04651	Ras	CHICK|Ensembl=ENSGALG00000006885|UniProtKB=P08642	GTPase HRas	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	ARATH|TAIR=AT2G41340|UniProtKB=Q9ZVB9	DNA-directed RNA polymerases IV and V subunit 5B	ISS	11313498	PubMed	PTHR10535:SF2	DNA-DIRECTED RNA POLYMERASE V SUBUNIT 5A-RELATED
P00010	B cell activation	P00383	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	HUMAN|HGNC=6025|UniProtKB=P10145	Interleukin-8	ISS	2007144	PubMed	PTHR10179:SF70	INTERLEUKIN-8
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=102705|UniProtKB=P63213	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P06959	CCKR signaling map	P07228	MAPK1/3	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	RCA	9324163	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	FUSNN|EnsemblGenome=FN1055|UniProtKB=Q8REP3	Cysteine synthase	ISS			PTHR10314:SF159	CYSTEINE SYNTHASE A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00049	Parkinson disease	P01212	p38 MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	NAS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CAEBR|Gene=CBG02401|UniProtKB=A8WUE7	Protein CBR-NMR-1	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P06959	CCKR signaling map	P07123	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	RCA	12065595	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ENTHI|EnsemblGenome=EHI_107290|UniProtKB=B1N2P0	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	RCA	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	SCHMA|EnsemblGenome=Smp_020170|UniProtKB=G4V8E3	Voltage-dependent calcium channel (Fragment)	ISS	8386525	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P00024	Glycolysis	P00678	Enolase	BOVIN|Ensembl=ENSBTAG00000011274|UniProtKB=A6QR19	ENO2 protein	ISS	86042683	PubMed	PTHR11902:SF10	GAMMA-ENOLASE
P00010	B cell activation	P00384	p38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04393	Ras Pathway	P04578	Rho	BOVIN|Ensembl=ENSBTAG00000004279|UniProtKB=P61585	Transforming protein RhoA	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00037	Ionotropic glutamate receptor pathway	P01005	NR2D	MOUSE|MGI=MGI=95823|UniProtKB=Q03391	Glutamate receptor ionotropic, NMDA 2D	ISS	14698601	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00021	FGF signaling pathway	P00639	Shc	MOUSE|MGI=MGI=106179|UniProtKB=Q61120	SHC-transforming protein 3	IDA	8610109	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	CHICK|Ensembl=ENSGALG00000004270|UniProtKB=O93344	Retinal dehydrogenase 2	IC	14724059	PubMed	PTHR11699:SF102	RETINAL DEHYDROGENASE 2
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=109485|UniProtKB=Q9WUD6	Protein Wnt-8b	TAS	11266476	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00056	VEGF signaling pathway	P01417	Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	ISS	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MACMU|Ensembl=ENSMMUG00000010367|UniProtKB=F6R0F5	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF335	MYOSIN-11
P05918	p38 MAPK pathway	P06034	MKK4	BOVIN|Ensembl=ENSBTAG00000012103|UniProtKB=A5PJP8	MAP2K4 protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00057	Wnt signaling pathway	P01465	Ggamma	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00047	PDGF signaling pathway	P01152	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	CANLF|Ensembl=ENSCAFG00000009967|UniProtKB=F1PGZ2	Muscarinic acetylcholine receptor	ISS	12915051	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P04393	Ras Pathway	P04552	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IDA	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	BOVIN|Ensembl=ENSBTAG00000007964|UniProtKB=Q148J6	Actin-related protein 2/3 complex subunit 4	ISS	9230079	PubMed	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	9395335	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	MACMU|Ensembl=ENSMMUG00000001661|UniProtKB=F7GR69	Uncharacterized protein	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00021	FGF signaling pathway	P00628	JNK1-3	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IGI	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04396	Vitamin D metabolism and pathway	P04604	FdxR	MYCTU|EnsemblGenome=Rv0886|UniProtKB=P9WJI1	Probable ferredoxin/ferredoxin--NADP reductase	ISS			PTHR11938:SF114	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01444	Wnt	MACMU|Ensembl=ENSMMUG00000007765|UniProtKB=F7CW57	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P04371	5-Hydroxytryptamine biosynthesis	P04399	Tryptophan hydroxylase	BOVIN|Ensembl=ENSBTAG00000005343|UniProtKB=F1N5Q8	Uncharacterized protein	ISS	14597720	PubMed	PTHR11473:SF23	TRYPTOPHAN 5-HYDROXYLASE 1
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00925	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00790	beta-Tubulin	MACMU|Ensembl=ENSMMUG00000013187|UniProtKB=F6XQ37	Tubulin beta-1 chain	ISS	9454836	PubMed	PTHR11588:SF112	TUBULIN BETA-1 CHAIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	RCA	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CHICK|Ensembl=ENSGALG00000015434|UniProtKB=F1NU20	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P02750	Lipoate_biosynthesis	P03004	Lipoate synthase	HUMAN|HGNC=16429|UniProtKB=O43766	Lipoyl synthase, mitochondrial	ISS			PTHR10949:SF0	LIPOYL SYNTHASE, MITOCHONDRIAL
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01444	Wnt	DROME|FlyBase=FBgn0004009|UniProtKB=P09615	Protein wingless	IDA	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00018	EGF receptor signaling pathway	P00565	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MACMU|Ensembl=ENSMMUG00000009341|UniProtKB=F6UA54	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00012	Cadherin signaling pathway	P00468	Src	CANLF|Ensembl=ENSCAFG00000008755|UniProtKB=E2RSH8	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00009	Axon guidance mediated by netrin	P00363	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	14505573	PubMed	PTHR10048:SF14	PI-3 KINASE
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	CHICK|Ensembl=ENSGALG00000000085|UniProtKB=Q5ZIG5	Uncharacterized protein	ISS			PTHR10937:SF2	GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE  ISOMERIZING  1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MOUSE|MGI=MGI=104589|UniProtKB=P63268	Actin, gamma-enteric smooth muscle	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00056	VEGF signaling pathway	P01411	Ras	ANOGA|EnsemblGenome=AGAP002219|UniProtKB=Q7QK91	AGAP002219-PA	ISS	10684567	PubMed	PTHR24070:SF385	GTPASE HRAS
P00047	PDGF signaling pathway	P01173	STAT	MACMU|Ensembl=ENSMMUG00000010705|UniProtKB=F7G8V4	Signal transducer and activator of transcription	ISS	96210005	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00012	Cadherin signaling pathway	P00470	F-actin	CAEEL|WormBase=WBGene00000064|UniProtKB=P10984	Actin-2	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02777	Succinate to proprionate conversion	P03163	Methylmalonyl-CoA decarboxylase	STRCO|Gene=CAD30916|UniProtKB=Q7AKI7	Propionyl-CoA carboxylase complex B subunit	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P00057	Wnt signaling pathway	P01435	SWI/SNF	HUMAN|HGNC=11102|UniProtKB=Q9NZC9	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1	IDA	11532957	PubMed	PTHR10799:SF731	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A-LIKE PROTEIN 1
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	CHICK|Ensembl=ENSGALG00000011699|UniProtKB=F1NEC3	Uncharacterized protein	IGI	21222856	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00054	Toll receptor signaling pathway	P01369	MKK1	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00005	Angiogenesis	P00227	PLA2	DANRE|ZFIN=ZDB-GENE-990415-45|UniProtKB=P50392	Cytosolic phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05918	p38 MAPK pathway	P06043	ASK1	PANTR|Ensembl=ENSPTRG00000024326|UniProtKB=H2R231	Uncharacterized protein	ISS	12968034	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P02738	De novo purine biosynthesis	P02905	Amidophosphoribosyl transferase	SYNY3|EnsemblGenome=BAA10132|UniProtKB=Q55621	Amidophosphoribosyltransferase	ISS			PTHR11907:SF0	AMIDOPHOSPHORIBOSYLTRANSFERASE
P05913	Enkephalin release	P05972	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00318	PKCs	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MOUSE|MGI=MGI=95770|UniProtKB=P30678	Guanine nucleotide-binding protein subunit alpha-15	IDA	11534853	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P02731	Biotin biosynthesis	P02856	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	BACSU|EnsemblGenome=BSU30230|UniProtKB=P53555	L-Lysine--8-amino-7-oxononanoate transaminase	ISS			PTHR42684:SF3	ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE
P00036	Interleukin signaling pathway	P00975	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	IDA	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00025	Hedgehog signaling pathway	P00682	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00054	Toll receptor signaling pathway	G01550	Gene trancription	BOVIN|Gene=IFNB1|UniProtKB=P01578	Interferon beta-1	ISS			PTHR11691:SF43	INTERFERON BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IC	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00644	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00053	T cell activation	P01332	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01131	MKP5	PANTR|Ensembl=ENSPTRG00000001594|UniProtKB=H2Q0H2	Dual specificity phosphatase 12	ISS			PTHR10159:SF293	DUAL SPECIFICITY PROTEIN PHOSPHATASE 12
P00059	p53 pathway	P04635	Sumo-1 ligase	MACMU|Ensembl=ENSMMUG00000030253|UniProtKB=F6RJN3	Small ubiquitin-related modifier	ISS			PTHR10562:SF11	SMALL UBIQUITIN-RELATED MODIFIER 2-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	RCA	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02746	Heme biosynthesis	P02981	Glutamate-1-semialdehyde aminotransferase	ARATH|TAIR=AT3G48730|UniProtKB=Q42522	Glutamate-1-semialdehyde 2,1-aminomutase 2, chloroplastic	ISS			PTHR43713:SF2	GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE 1, CHLOROPLASTIC-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P05913	Enkephalin release	P05974	G-Protein (i)	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00049	Parkinson disease	P01238	14-3-3	CANLF|Ensembl=ENSCAFG00000031015|UniProtKB=J9P6N4	Uncharacterized protein	ISS	14593000	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00034	Integrin signalling pathway	P00924	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01440	Cadherin	ANOGA|EnsemblGenome=AGAP007905|UniProtKB=Q7Q3J3	AGAP007905-PA (Fragment)	ISS			PTHR43956:SF7	CADHERIN-4
P00046	Oxidative stress response	P01138	MKK4	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS	602425	OMIM	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	CHICK|Ensembl=ENSGALG00000003270|UniProtKB=F1NR31	Uncharacterized protein	ISS	15328036	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	PANTR|Ensembl=ENSPTRG00000010806|UniProtKB=H2QG00	Low density lipoprotein receptor-related protein 3	ISS	11907044	PubMed	PTHR44062:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 3
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00019	Endothelin signaling pathway	P00590	IP3 R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P05913	Enkephalin release	P05972	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	176910	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	RCA	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IDA	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00046	Oxidative stress response	P01135	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00020	FAS signaling pathway	P00593	Caspase9	MACMU|Ensembl=ENSMMUG00000018163|UniProtKB=F7FNC1	Caspase	ISS	9390557	PubMed	PTHR10454:SF157	CASPASE-9
P00047	PDGF signaling pathway	P01162	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	MOUSE|MGI=MGI=1351342|UniProtKB=Q3UVX5	Metabotropic glutamate receptor 5	ISS	92317054	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	XENTR|Xenbase=XB-GENE-963560|UniProtKB=Q0VFC4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00023	General transcription regulation	P00660	RNA Polymerase II	DROME|FlyBase=FBgn0026373|UniProtKB=O97183	GH07456p	ISS	2187864	PubMed	PTHR11800:SF2	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3
P00056	VEGF signaling pathway	P01409	cPLA2	CHICK|Ensembl=ENSGALG00000005065|UniProtKB=P49147	Cytosolic phospholipase A2	ISS	94299545	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PHYPA|Gene=PHYPADRAFT_172686|UniProtKB=A9TYG6	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00018	EGF receptor signaling pathway	P00543	ERK1-2	ARATH|TAIR=AT1G59580|UniProtKB=Q39022	Mitogen-activated protein kinase 2	ISS			PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05916	Opioid prodynorphin pathway	P05998	Kappa Receptor	HUMAN|HGNC=8154|UniProtKB=P41145	Kappa-type opioid receptor	RCA	11259498	PubMed	PTHR24229:SF1	KAPPA-TYPE OPIOID RECEPTOR
P00006	Apoptosis signaling pathway	P00310	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	CAEEL|WormBase=WBGene00004769|UniProtKB=P52166	Presenilin sel-12	IDA	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00008	Axon guidance mediated by Slit/Robo	P00344	Netrin	DROME|FlyBase=FBgn0015774|UniProtKB=Q24568	Netrin-B	ISS			PTHR10574:SF365	NETRIN-1
P00029	Huntington disease	P00796	Kainate receptor	PANTR|Ensembl=ENSPTRG00000013825|UniProtKB=H2RAK4	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00019	Endothelin signaling pathway	P00587	Raf-1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IGI	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	ARATH|TAIR=AT1G13890|UniProtKB=Q9LMG8	Putative SNAP25 homologous protein SNAP30	IC			PTHR19305:SF7	SNAP25 HOMOLOGOUS PROTEIN SNAP30-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00053	T cell activation	P01300	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	MACMU|Ensembl=ENSMMUG00000021423|UniProtKB=F7EEZ1	Phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00036	Interleukin signaling pathway	P00990	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00056	VEGF signaling pathway	P01408	Akt/PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1170702	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00018	EGF receptor signaling pathway	P00547	PP2A	PANTR|Ensembl=ENSPTRG00000017238|UniProtKB=H2QRH7	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00046	Oxidative stress response	P01129	JNK1/2	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00010	B cell activation	P00375	Calmodulin	HUMAN|HGNC=1442|UniProtKB=P62158	Calmodulin	IDA	10487978	PubMed	PTHR23050:SF311	CALMODULIN
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12805548	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	CANLF|Ensembl=ENSCAFG00000024151|UniProtKB=E2R795	Tyrosine-protein kinase receptor	ISS	10226785	PubMed	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00029	Huntington disease	P00780	Microtubule	STRPU|EnsemblGenome=SPU_016007|UniProtKB=W4YJP3	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00021	FGF signaling pathway	P00633	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00049	Parkinson disease	P01208	Hsp70	YEAST|SGD=S000000905|UniProtKB=P22202	Heat shock protein SSA4	IDA	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000047062|UniProtKB=G3MX13	Uncharacterized protein	ISS	11907044	PubMed	PTHR44062:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 3
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00046	Oxidative stress response	P01128	MEF-2	XENTR|Xenbase=XB-GENE-486958|UniProtKB=F6WS85	Uncharacterized protein	ISS	11274345	PubMed	PTHR11945:SF145	MYOCYTE-SPECIFIC ENHANCER FACTOR 2A
P00046	Oxidative stress response	P01134	cPLA2	RAT|RGD=67366|UniProtKB=P50393	Cytosolic phospholipase A2	TAS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	BOVIN|Gene=ARRB2|UniProtKB=P32120	Beta-arrestin-2	IDA	9388255	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P02774	Salvage pyrimidine deoxyribonucleotides	P03145	Uracil phosphorylase	STRCO|Gene=CAC33055|UniProtKB=Q9AK36	Thymidine phosphorylase	ISS	12000953	PubMed	PTHR10515:SF0	THYMIDINE PHOSPHORYLASE
P00006	Apoptosis signaling pathway	P00310	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TRIAD|EnsemblGenome=TriadG35956|UniProtKB=Q7YTV5	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	P01471	alpha-catenin	CAEEL|WormBase=WBGene00001978|UniProtKB=P90947	Alpha-catenin-like protein hmp-1	ISS			PTHR18914:SF9	CATENIN ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MOUSE|MGI=MGI=96274|UniProtKB=P28334	5-hydroxytryptamine receptor 1B	ISS	12181435	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P00029	Huntington disease	P00778	NMDA receptor	MOUSE|MGI=MGI=95823|UniProtKB=Q03391	Glutamate receptor ionotropic, NMDA 2D	IDA	14698601	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IC	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00047	PDGF signaling pathway	P01159	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05915	Opioid proenkephalin pathway	P05992	met-Enkephalin	DANRE|ZFIN=ZDB-GENE-030729-31|UniProtKB=A8E7S2	Uncharacterized protein	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00021	FGF signaling pathway	P00629	PP2A	XENTR|Xenbase=XB-GENE-946380|UniProtKB=Q0D2F4	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform	ISS	1849734	PubMed	PTHR11871:SF1	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B BETA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1203729|UniProtKB=Q61194	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00029	Huntington disease	P00790	beta-Tubulin	LEIMA|EnsemblGenome=LmjF.08.1230|UniProtKB=Q4QI42	Beta tubulin	TAS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	HUMAN|HGNC=1736|UniProtKB=P60953	Cell division control protein 42 homolog	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00057	Wnt signaling pathway	P01428	Frizzled	CAEBR|Gene=CBG03824|UniProtKB=A8WWU4	Protein CBR-MOM-5	ISS	8717036	PubMed	PTHR11309:SF47	FRIZZLED
P02753	Methionine biosynthesis	P03026	O-Succinyl homoserine lyase	SULSO|EnsemblGenome=SSO2368|UniProtKB=Q97W69	O-succinylhomoserine (Thiol)-lyase (Cystathionine gamma-synthase) (MetB)	ISS			PTHR11808:SF50	CYSTATHIONINE BETA-LYASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00006	Apoptosis signaling pathway	P00297	NFkappaB	HUMAN|HGNC=9956|UniProtKB=Q01201	Transcription factor RelB	ISS			PTHR24169:SF18	TRANSCRIPTION FACTOR RELB
P06959	CCKR signaling map	P07126	TCF7L2	HUMAN|HGNC=11634|UniProtKB=P15884	Transcription factor 4	RCA	18515095	PubMed	PTHR11793:SF10	TRANSCRIPTION FACTOR 4
P00019	Endothelin signaling pathway	P00586	Gq	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00029	Huntington disease	P00778	NMDA receptor	BOVIN|Ensembl=ENSBTAG00000018445|UniProtKB=E1BK87	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P04393	Ras Pathway	P04552	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IDA	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00060	Ubiquitin proteasome pathway	P01494	19S proteasome	MACMU|Ensembl=ENSMMUG00000017188|UniProtKB=F7HIL8	26S protease regulatory subunit 6B isoform 1	ISS			PTHR23073:SF8	26S PROTEASE REGULATORY SUBUNIT 6B
P00029	Huntington disease	P00807	Actin	RAT|RGD=2026|UniProtKB=P68035	Actin, alpha cardiac muscle 1	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00019	Endothelin signaling pathway	P00566	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05913	Enkephalin release	P05972	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00047	PDGF signaling pathway	P01143	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00056	VEGF signaling pathway	P01408	Akt/PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008026|UniProtKB=H2QAZ2	Syntaxin 1B	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00057	Wnt signaling pathway	P01463	Kremen	BOVIN|Ensembl=ENSBTAG00000009773|UniProtKB=F1MRR1	Uncharacterized protein	ISS			PTHR24269:SF13	KREMEN PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	BOVIN|Gene=CACNB1|UniProtKB=Q9MZL7	Voltage-dependent L-type calcium channel subunit beta-1	IC	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00053	T cell activation	P01324	rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	IDA	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	HUMAN|HGNC=4040|UniProtKB=Q14332	Frizzled-2	TAS	8717036	PubMed	PTHR11309:SF34	FRIZZLED-2
P00047	PDGF signaling pathway	P01165	SRF	MONDO|Ensembl=ENSMODG00000018981|UniProtKB=F7FP88	Uncharacterized protein	ISS	15647354	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00048	PI3 kinase pathway	P01187	IR	CAEEL|WormBase=WBGene00000898|UniProtKB=Q968Y9	Insulin-like receptor	IGI	97400619	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P00053	T cell activation	P01335	jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00020	FAS signaling pathway	P00607	Pro-Caspase6	DROME|FlyBase=FBgn0028381|UniProtKB=Q9VET9	AT03047p	IGI			PTHR10454:SF205	AT03047P
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	7925653	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12912997	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	TAS	12719720	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00047	PDGF signaling pathway	P01161	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00010	B cell activation	P00398	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IGI	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00007	Axon guidance mediated by semaphorins	P00340	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00828	Galphai	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	XENTR|Xenbase=XB-GENE-491433|UniProtKB=B1H2U0	Pten protein	ISS	10555148	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00006	Apoptosis signaling pathway	P00258	Bik	RAT|RGD=621547|UniProtKB=Q925D2	Bcl2-interacting killer, isoform CRA_a	IDA	11884414	PubMed	PTHR15018:SF1	BCL-2-INTERACTING KILLER
P00004	Alzheimer disease-presenilin pathway	P00115	Nicastrin	CANLF|Ensembl=ENSCAFG00000012557|UniProtKB=F1PU73	Uncharacterized protein	ISS	16096062	PubMed	PTHR21092:SF0	NICASTRIN
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00005	Angiogenesis	P00253	Axin	DANRE|ZFIN=ZDB-GENE-000403-1|UniProtKB=P57094	Axin-1	ISS	12356903	PubMed	PTHR10845:SF11	AXIN-1
P00057	Wnt signaling pathway	P01444	Wnt	TAKRU|Ensembl=ENSTRUG00000011562|UniProtKB=H2TX02	Protein Wnt	IDA	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CAEBR|Gene=CBG02167|UniProtKB=A8WS37	Protein CBG02167	ISS	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P04398	p53 pathway feedback loops 2	P04657	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	HUMAN|HGNC=129|UniProtKB=P68133	Actin, alpha skeletal muscle	IC	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	HUMAN|HGNC=2459|UniProtKB=P19784	Casein kinase II subunit alpha'	IDA	10617630	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00056	VEGF signaling pathway	P01423	p38MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00029	Huntington disease	P00807	Actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CAEBR|Gene=CBG04581|UniProtKB=A8WXZ5	Protein CBR-GAR-3	ISS			PTHR43914:SF8	MUSCARINIC ACETYLCHOLINE RECEPTOR GAR-3
P00005	Angiogenesis	P00221	JNK1	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00010	B cell activation	P00397	IKK	MACMU|Ensembl=ENSMMUG00000008351|UniProtKB=F7HRV5	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P05916	Opioid prodynorphin pathway	P06002	G-protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00010	B cell activation	P00402	Jnk	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00048	PI3 kinase pathway	P01205	NOS	RAT|RGD=3186|UniProtKB=Q62600	Nitric oxide synthase, endothelial	ISS	22462730	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00054	Toll receptor signaling pathway	P01358	ERK1	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00021	FGF signaling pathway	P00641	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00021	FGF signaling pathway	P00624	14-3-3	BOVIN|Gene=YWHAG|UniProtKB=P68252	14-3-3 protein gamma	ISS	10407019	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00005	Angiogenesis	P00199	JNKK1	CANLF|Ensembl=ENSCAFG00000017851|UniProtKB=F1PBB6	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00057	Wnt signaling pathway	P01465	Ggamma	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00021	FGF signaling pathway	P00628	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05918	p38 MAPK pathway	P06039	MSK2	MOUSE|MGI=MGI=1930076|UniProtKB=Q9Z2B9	Ribosomal protein S6 kinase alpha-4	RCA	9792677	PubMed	PTHR24351:SF41	RIBOSOMAL PROTEIN S6 KINASE ALPHA-4
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	14744463	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04572	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05918	p38 MAPK pathway	P06026	MEKK4	CANLF|Ensembl=ENSCAFG00000000760|UniProtKB=E2R9L4	Uncharacterized protein	ISS	12878610	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00057	Wnt signaling pathway	P01472	Histone deacetylase	CANLF|Ensembl=ENSCAFG00000006173|UniProtKB=E2R792	Histone deacetylase	ISS	10485845	PubMed	PTHR10625:SF132	HISTONE DEACETYLASE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00021	FGF signaling pathway	P00629	PP2A	MONDO|Ensembl=ENSMODG00000002945|UniProtKB=F6PKB8	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00736	CalDAG-GEF	BOVIN|Ensembl=ENSBTAG00000008006|UniProtKB=Q0VD52	RAS guanyl releasing protein 3 (Calcium and DAG-regulated)	ISS	10835426	PubMed	PTHR23113:SF178	RAS GUANYL-RELEASING PROTEIN 3
P00036	Interleukin signaling pathway	P00990	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02740	De novo pyrimidine ribonucleotides biosythesis	P02927	Dihydrooratate oxidase	ECOLI|EcoGene=EG10807|UniProtKB=P0A7E1	Dihydroorotate dehydrogenase (quinone)	ISS			PTHR43517:SF1	DIHYDROOROTATE DEHYDROGENASE  QUINONE , MITOCHONDRIAL
P00059	p53 pathway	P04609	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IGI	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00053	T cell activation	P01322	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00846	JAK	MACMU|Ensembl=ENSMMUG00000014558|UniProtKB=F7GT47	Tyrosine-protein kinase	ISS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02918	dUTP pyrophosphatase	ANOGA|Gene=AgaP_AGAP010159|UniProtKB=Q7Q0U6	AGAP010159-PA (Fragment)	ISS			PTHR11241:SF0	BCDNA.LD08534
P00046	Oxidative stress response	P01129	JNK1/2	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	IDA	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00056	VEGF signaling pathway	P01407	Erk	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00056	VEGF signaling pathway	P01409	cPLA2	PANTR|Ensembl=ENSPTRG00000001787|UniProtKB=H2Q0T0	Phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IDA	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	NEUCR|EnsemblGenome=EFNCRG00000004007|UniProtKB=P27121	Ornithine decarboxylase	ISS			PTHR11482:SF6	ORNITHINE DECARBOXYLASE 1-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00049	Parkinson disease	P01211	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00564	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	IPI	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00034	Integrin signalling pathway	P00925	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06959	CCKR signaling map	G07261	HBEGF	HUMAN|HGNC=3059|UniProtKB=Q99075	Proheparin-binding EGF-like growth factor	RCA	9207188	PubMed	PTHR10740:SF4	PROHEPARIN-BINDING EGF-LIKE GROWTH FACTOR
P00053	T cell activation	P01332	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CANLF|Ensembl=ENSCAFG00000008653|UniProtKB=F1PE26	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CAEBR|Gene=CBG23090|UniProtKB=A8Y4R0	Protein CBG23090	ISS	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	THEKO|EnsemblGenome=TK1002|UniProtKB=Q5JIE6	Adenylosuccinate synthetase	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00021	FGF signaling pathway	P00627	ERK1-2	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00633	Ras	EMENI|EnsemblGenome=CADANIAG00002552|UniProtKB=Q12526	Ras-like protein	ISS	7997267	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P06959	CCKR signaling map	P07088	RYR1/2/3	HUMAN|HGNC=10483|UniProtKB=P21817	Ryanodine receptor 1	RCA	11279177	PubMed	PTHR13715:SF15	RYANODINE RECEPTOR 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IC	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00025	Hedgehog signaling pathway	P00682	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00243	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01444	Wnt	XENTR|Gene=wnt11b-1|UniProtKB=Q66II0	Protein Wnt-11b-1	ISS	8717036	PubMed	PTHR12027:SF34	PROTEIN WNT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_125401|UniProtKB=C3ZTX6	Putative uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PRIPA|Gene=PPA02893|UniProtKB=H3DZP2	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF120	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00570	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	IDA	176892	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01447	Dishevelled	RAT|RGD=1308834|UniProtKB=D4ADV8	Protein Dvl3	ISS	11212302	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g210933|UniProtKB=A7SEA7	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00572	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	RCA	9298898	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00045	Notch signaling pathway	P01100	CoA	DROME|FlyBase=FBgn0020388|UniProtKB=Q9VTZ1	GH11602p	TAS	11112321	PubMed	PTHR22880:SF124	HISTONE ACETYLTRANSFERASE KAT2A
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00059	p53 pathway	P04623	CBP	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	IDA	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P06664	Gonadotropin-releasing hormone receptor pathway	P06849	Sos	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	RCA	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00778	NMDA receptor	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	IDA	11554549	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	ARATH|TAIR=AT1G59580|UniProtKB=Q39022	Mitogen-activated protein kinase 2	TAS			PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00021	FGF signaling pathway	P00629	PP2A	RAT|RGD=1305657|UniProtKB=A0A0G2JTA1	Protein Ppp2r5e	ISS	10092233	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00012	Cadherin signaling pathway	P00475	Frizzled	DROME|FlyBase=FBgn0001085|UniProtKB=P18537	Frizzled	IDA	8717036	PubMed	PTHR11309:SF47	FRIZZLED
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	TAKRU|Ensembl=ENSTRUG00000002245|UniProtKB=H2RYC6	Uncharacterized protein (Fragment)	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00057	Wnt signaling pathway	P01435	SWI/SNF	STRCO|Gene=CAB60181|UniProtKB=Q9RKT0	Putative helicase	ISS	11532957	PubMed	PTHR10799:SF810	SUBFAMILY NOT NAMED
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	10704417	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	HUMAN|HGNC=239|UniProtKB=P40145	Adenylate cyclase type 8	IDA	12890691	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00010	B cell activation	P00375	Calmodulin	STRPU|EnsemblGenome=SPU_017814|UniProtKB=W4YPT6	Uncharacterized protein	ISS			PTHR23050:SF263	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01020	NSF	CAEEL|WormBase=WBGene00003818|UniProtKB=Q94392	Vesicle-fusing ATPase	ISS	11348590	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P05731	GABA-B receptor II signaling	P05754	Ggamma	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	HUMAN|HGNC=7167|UniProtKB=O60882	Matrix metalloproteinase-20	TAS	12834808	PubMed	PTHR10201:SF125	MATRIX METALLOPROTEINASE-20
P00049	Parkinson disease	P01208	Hsp70	TRIVA|Gene=TVAG_340390|UniProtKB=A2EKF3	Mitochondrial-type HSP70, putative	IDA	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00056	VEGF signaling pathway	P01425	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	15572354	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IDA	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P02741	Flavin biosynthesis	P02936	FAD synthetase	CAEEL|WormBase=WBGene00011224|UniProtKB=Q21918	Uncharacterized protein	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00189	Fzd	HUMAN|HGNC=4040|UniProtKB=Q14332	Frizzled-2	ISS	8717036	PubMed	PTHR11309:SF34	FRIZZLED-2
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=7568|UniProtKB=P35580	Myosin-10	IC	89264452	PubMed	PTHR13140:SF328	MYOSIN-10
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00021	FGF signaling pathway	P00633	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	91232861	PubMed	PTHR24070:SF385	GTPASE HRAS
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008422|UniProtKB=F6VUT7	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00629	PP2A	BOVIN|Ensembl=ENSBTAG00000007061|UniProtKB=Q08DP7	Protein phosphatase 2, regulatory subunit B', beta isoform	ISS	96161994	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02746	Heme biosynthesis	P02972	Ferrochelatase	YEAST|SGD=S000005702|UniProtKB=P16622	Ferrochelatase, mitochondrial	ISS			PTHR11108:SF1	FERROCHELATASE, MITOCHONDRIAL
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00021	FGF signaling pathway	P00642	MEK1-2	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04398	p53 pathway feedback loops 2	P04665	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02785	Valine biosynthesis	P03216	Acetolactate synthase	STRCO|Gene=CAB66308|UniProtKB=Q9RDF9	Putative acetolactate synthase	ISS			PTHR18968:SF13	ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00034	Integrin signalling pathway	P00926	GRAF	HUMAN|HGNC=26099|UniProtKB=A1A4S6	Rho GTPase-activating protein 10	IPI	8649427	PubMed	PTHR12552:SF5	RHO GTPASE-ACTIVATING PROTEIN 10
P00048	PI3 kinase pathway	P01192	p110	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00627	ERK1-2	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	PANTR|Ensembl=ENSPTRG00000001767|UniProtKB=G2HG81	Actin-related protein 2/3 complex subunit 5	ISS	12473693	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	RAT|RGD=620401|UniProtKB=P97583	B1 bradykinin receptor	IDA	12130679	PubMed	PTHR24228:SF28	B1 BRADYKININ RECEPTOR
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	SULSO|EnsemblGenome=SSO1907|UniProtKB=P80053	Glutamate dehydrogenase 2	ISS			PTHR11606:SF13	GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL
P05918	p38 MAPK pathway	P06026	MEKK4	MOUSE|MGI=MGI=1346875|UniProtKB=O08648	Mitogen-activated protein kinase kinase kinase 4	RCA	9079650	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	IXOSC|EnsemblGenome=ISCW009711|UniProtKB=B7Q3T6	THO complex subunit, putative	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000017333|UniProtKB=Q5DRD0	Protocadherin beta-4	ISS	8120095	PubMed	PTHR24028:SF55	PROTOCADHERIN BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000012822|UniProtKB=F6PX40	Phosphoinositide phospholipase C	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P00021	FGF signaling pathway	P00623	FGF	DANRE|ZFIN=ZDB-GENE-050221-6|UniProtKB=Q5TKR3	Fibroblast growth factor	ISS	9847253	PubMed	PTHR11486:SF17	FIBROBLAST GROWTH FACTOR 12
P00057	Wnt signaling pathway	P01465	Ggamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04393	Ras Pathway	P04556	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00564	Rac	ENTHI|EnsemblGenome=EHI_129750|UniProtKB=C4M5Q7	Rho family GTPase	IGI	12932731	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00049	Parkinson disease	P01238	14-3-3	CAEBR|Gene=CBG17289|UniProtKB=A8XQR9	14-3-3 zeta	ISS	10407019	PubMed	PTHR18860:SF13	14-3-3 PROTEIN ZETA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	IC	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00021	FGF signaling pathway	P00623	FGF	RAT|RGD=620130|UniProtKB=Q8R5L5	Fibroblast growth factor	ISS	11801566	PubMed	PTHR11486:SF25	FIBROBLAST GROWTH FACTOR 6
P00057	Wnt signaling pathway	P01427	Naked	MACMU|Ensembl=ENSMMUG00000019439|UniProtKB=F6R1B1	Uncharacterized protein	ISS	11356022	PubMed	PTHR22611:SF1	PROTEIN NAKED CUTICLE HOMOLOG 2
P04395	Vasopressin synthesis	P04589	Signal Peptidase	ARATH|TAIR=AT2G39960|UniProtKB=P58684	Probable signal peptidase complex subunit 2	IC	2092035	PubMed	PTHR13085:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 2
P00010	B cell activation	P00381	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06773	gnai/o	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00029	Huntington disease	P00778	NMDA receptor	CAEEL|WormBase=WBGene00003774|UniProtKB=G5EGQ9	NMDA class glutamate Receptor	IDA	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	PANTR|Ensembl=ENSPTRG00000001854|UniProtKB=H2Q0X1	Uncharacterized protein	ISS	600104	OMIM	PTHR10024:SF223	SYNAPTOTAGMIN-2
P00046	Oxidative stress response	P01129	JNK1/2	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00034	Integrin signalling pathway	P00924	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IPI	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	MOUSE|MGI=MGI=1321159|UniProtKB=P63330	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00321	HSP70	PHYPA|Gene=PHYPADRAFT_228249|UniProtKB=A9U4N3	Predicted protein	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00018	EGF receptor signaling pathway	P00558	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00034	Integrin signalling pathway	P00906	Rap1	HUMAN|HGNC=9857|UniProtKB=P61224	Ras-related protein Rap-1b	IPI	1904317	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MOUSE|MGI=MGI=1339967|UniProtKB=B1AR69	Protein Myh13	ISS	89264452	PubMed	PTHR13140:SF504	MYOSIN-13
P00021	FGF signaling pathway	P00643	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	MOUSE|MGI=MGI=109355|UniProtKB=O35526	Syntaxin-1A	ISS	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00018	EGF receptor signaling pathway	P00558	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	BOVIN|Gene=TRPC1|UniProtKB=O18784	Short transient receptor potential channel 1	IDA	11055438	PubMed	PTHR10117:SF56	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 1
P00021	FGF signaling pathway	P00633	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00006	Apoptosis signaling pathway	P00269	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9836512	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05913	Enkephalin release	P05974	G-Protein (i)	DAPPU|EnsemblGenome=DAPPUDRAFT_206575|UniProtKB=E9FUX0	Guanine nucleotide binding protein, beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	IC	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	XENTR|Xenbase=XB-GENE-5877220|UniProtKB=F6SZZ8	Uncharacterized protein	ISS			PTHR13140:SF417	UNCONVENTIONAL MYOSIN-ID
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00866	Cytokine receptor	MOUSE|MGI=MGI=107655|UniProtKB=P15261	Interferon gamma receptor 1	IDA	14525967	PubMed	PTHR20859:SF5	INTERFERON GAMMA RECEPTOR 1
P00047	PDGF signaling pathway	P01159	SOS	DICDI|dictyBase=DDB_G0269222|UniProtKB=Q8IS21	Ras guanine nucleotide exchange factor B	ISS			PTHR23113:SF163	RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR B
P00057	Wnt signaling pathway	P01443	Phospholipase C	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00019	Endothelin signaling pathway	P00591	PLCbeta	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IGI	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CANLF|Ensembl=ENSCAFG00000007782|UniProtKB=F1PWZ2	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF358	MYOSIN-7B
P00058	mRNA splicing	P01478	U2	DROME|FlyBase=FBgn0003449|UniProtKB=P43332	U1 small nuclear ribonucleoprotein A	ISS			PTHR10501:SF13	U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	BRAFL|Gene=BRAFLDRAFT_220697|UniProtKB=C3ZSF0	Putative uncharacterized protein	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04669	ATM	SCHPO|PomBase=SPCC23B6.03c|UniProtKB=O74630	Serine/threonine-protein kinase tel1	ISS			PTHR11139:SF72	SERINE-PROTEIN KINASE ATM
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	IC	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P05915	Opioid proenkephalin pathway	P05988	peptide E	DANRE|ZFIN=ZDB-GENE-030729-31|UniProtKB=A8E7S2	Uncharacterized protein	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	ARATH|TAIR=AT1G66200|UniProtKB=Q8LCE1	Glutamine synthetase cytosolic isozyme 1-2	ISS			PTHR20852:SF58	GLUTAMINE SYNTHETASE CYTOSOLIC ISOZYME 1-2
P00029	Huntington disease	P00796	Kainate receptor	TAKRU|Ensembl=ENSTRUG00000009259|UniProtKB=H2TF39	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	RAT|RGD=621060|UniProtKB=O88777	Presenilin-2	IDA	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00005	Angiogenesis	P00223	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01457	GBeta	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02738	De novo purine biosynthesis	P02892	5-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase	DEIRA|EnsemblGenome=DR_2178|UniProtKB=Q9RSE6	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00398	IP3R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IGI	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00049	Parkinson disease	P01208	Hsp70	MOUSE|MGI=MGI=96245|UniProtKB=P38647	Stress-70 protein, mitochondrial	IDA	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P00006	Apoptosis signaling pathway	P00266	SEK1	MOUSE|MGI=MGI=1346869|UniProtKB=P47809	Dual specificity mitogen-activated protein kinase kinase 4	RCA			PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00018	EGF receptor signaling pathway	P00547	PP2A	IXOSC|EnsemblGenome=ISCW014549|UniProtKB=B7QGY5	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	HUMAN|HGNC=14261|UniProtKB=Q9NS28	Regulator of G-protein signaling 18	IDA	8756726	PubMed	PTHR10845:SF155	REGULATOR OF G-PROTEIN SIGNALING 18
P00015	Circadian clock system	P00502	Casein kinase I	MOUSE|MGI=MGI=1355272|UniProtKB=Q9DC28	Casein kinase I isoform delta	ISS	11437445	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00057	Wnt signaling pathway	P01446	Calcineurin	CAEBR|Gene=CBG08362|UniProtKB=A8X6D8	Serine/threonine-protein phosphatase	ISS	12015605	PubMed	PTHR11668:SF118	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED
P00034	Integrin signalling pathway	P00924	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CHICK|Gene=CHRNA1|UniProtKB=P09479	Acetylcholine receptor subunit alpha	IC	85270494	PubMed	PTHR18945:SF74	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04398	p53 pathway feedback loops 2	P04665	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=18539|UniProtKB=P61266	Syntaxin-1B	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CAEBR|Gene=CBG02025|UniProtKB=A8WRU2	Protein CBR-NMY-1	ISS			PTHR13140:SF574	MYOSIN HEAVY CHAIN, NON-MUSCLE
P00057	Wnt signaling pathway	P01472	Histone deacetylase	ARATH|TAIR=AT4G38130|UniProtKB=O22446	Histone deacetylase 19	IDA	10485845	PubMed	PTHR10625:SF178	HISTONE DEACETYLASE 19
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	91056091	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00018	EGF receptor signaling pathway	P00559	MEK1-2	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P02753	Methionine biosynthesis	P03024	Homocysteine transmethylase	MOUSE|MGI=MGI=894292|UniProtKB=A6H5Y3	Methionine synthase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P00005	Angiogenesis	P00204	PLD	MOUSE|MGI=MGI=892877|UniProtKB=P97813	Phospholipase D2	ISS	12615079	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=1953|UniProtKB=P08173	Muscarinic acetylcholine receptor M4	IDA	91373358	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P05918	p38 MAPK pathway	P06015	p38gamma	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	RCA	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IGI	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00008	Axon guidance mediated by Slit/Robo	P00342	Slit	CHICK|Ensembl=ENSGALG00000014419|UniProtKB=F1NR89	Uncharacterized protein	ISS	10432110	PubMed	PTHR24373:SF107	SLIT HOMOLOG 2 PROTEIN
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	IDA	14744463	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P05730	Endogenous cannabinoid signaling	P05746	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IC	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00004	Alzheimer disease-presenilin pathway	P00139	E-cadherin transmembrane fragment	PANTR|Ensembl=ENSPTRG00000008269|UniProtKB=H2QBE4	Cadherin 3, type 1, P-cadherin (Placental)	ISS	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P00010	B cell activation	P00381	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00705	Gsalpha	MACMU|Ensembl=ENSMMUG00000010266|UniProtKB=F6PV18	Uncharacterized protein	ISS	14500986	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00049	Parkinson disease	P01227	20S proteasome	ARATH|TAIR=AT2G27020|UniProtKB=O23715	Proteasome subunit alpha type-3	ISS	12859888	PubMed	PTHR11599:SF103	PROTEASOME SUBUNIT ALPHA TYPE-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	DANRE|ZFIN=ZDB-GENE-060531-50|UniProtKB=F1R6C7	Uncharacterized protein	ISS			PTHR13140:SF676	MYOSIN, HEAVY POLYPEPTIDE 2, FAST MUSCLE SPECIFIC
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	METAC|EnsemblGenome=MA_3407|UniProtKB=Q8TKJ8	Cytidine/deoxycytidylate deaminase family protein	ISS			PTHR44192:SF2	SUBFAMILY NOT NAMED
P00010	B cell activation	P00383	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	XENTR|Xenbase=XB-GENE-481916|UniProtKB=F6YF14	Presenilin	ISS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00015	Circadian clock system	G01501	cry	MACMU|Ensembl=ENSMMUG00000002453|UniProtKB=F7HH05	Cryptochrome-2	ISS	10428031	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P02746	Heme biosynthesis	P02976	Protoporphyrinogen oxidase	CANLF|Ensembl=ENSCAFG00000012811|UniProtKB=E2RG94	Orexin	ISS			PTHR42923:SF3	PROTOPORPHYRINOGEN OXIDASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	YEAST|SGD=S000001649|UniProtKB=P05986	cAMP-dependent protein kinase type 3	ISS	89107990	PubMed	PTHR24353:SF73	CAMP-DEPENDENT PROTEIN KINASE TYPE 1-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01161	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	RAT|RGD=2744|UniProtKB=P31422	Metabotropic glutamate receptor 3	ISS	12488551	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P06209	ALP23B signaling pathway	P06222	SARA	DROME|FlyBase=FBgn0026369|UniProtKB=Q7K9H6	FI05490p	IEA	12040180	PubMed	PTHR22835:SF299	FI05490P
P00057	Wnt signaling pathway	P01455	Smad4	XENTR|Xenbase=XB-GENE-1018193|UniProtKB=Q6DIS7	Mothers against decapentaplegic homolog	ISS	12736218	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00547	PP2A	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	88248000	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	RAT|RGD=61862|UniProtKB=P19491	Glutamate receptor 2	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00021	FGF signaling pathway	P00641	SOS	DICDI|dictyBase=DDB_G0274605|UniProtKB=Q8SSQ0	Ras guanine nucleotide exchange factor R	ISS			PTHR23113:SF162	RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR R
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	XENTR|Xenbase=XB-GENE-482185|UniProtKB=Q6GLE7	Tubulin beta chain	ISS	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00008	Axon guidance mediated by Slit/Robo	P00347	Abl	BOVIN|Ensembl=ENSBTAG00000017976|UniProtKB=F1MXG8	Tyrosine-protein kinase	ISS			PTHR24418:SF88	TYROSINE-PROTEIN KINASE ABL1
P00019	Endothelin signaling pathway	P00590	IP3 R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IGI	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00626	Spry	XENTR|Xenbase=XB-GENE-482101|UniProtKB=Q5Y173	Sprouty2	ISS	21231191	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=11330|UniProtKB=P30872	Somatostatin receptor type 1	IDA	12441358	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P00048	PI3 kinase pathway	P01182	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000010837|UniProtKB=F1N3N9	Uncharacterized protein	ISS			PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04384	Gamma-aminobutyric acid synthesis	P04482	Glutamate decarboxylase	MOUSE|MGI=MGI=2180098|UniProtKB=Q9DBE0	Cysteine sulfinic acid decarboxylase	ISS			PTHR11999:SF114	CYSTEINE SULFINIC ACID DECARBOXYLASE
P00052	TGF-beta signaling pathway	P01284	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	BOVIN|Ensembl=ENSBTAG00000018204|UniProtKB=Q9BE40	Myosin-1	IEP	89264452	PubMed	PTHR13140:SF484	MYOSIN-1
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	ORNAN|Ensembl=ENSOANG00000005936|UniProtKB=F6PQC9	Uncharacterized protein	ISS	8576107	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00021	FGF signaling pathway	P00632	Akt	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	IGI	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04397	p53 pathway by glucose deprivation	P04641	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00887	IRS 1-4	RAT|RGD=69317|UniProtKB=B1WBQ1	Insulin receptor substrate 3	ISS	5031805	gi	PTHR10614:SF8	SUBFAMILY NOT NAMED
P04395	Vasopressin synthesis	P04590	Vasopressin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00630	RKIP	ARATH|TAIR=AT5G03840|UniProtKB=P93003	Protein TERMINAL FLOWER 1	ISS			PTHR11362:SF13	PROTEIN TERMINAL FLOWER 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00627	ERK1-2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02738	De novo purine biosynthesis	P02900	AICAR transformylase	SYNY3|EnsemblGenome=BAA18861|UniProtKB=P74741	Bifunctional purine biosynthesis protein PurH	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P00057	Wnt signaling pathway	P01435	SWI/SNF	ORNAN|Ensembl=ENSOANG00000002862|UniProtKB=F6U824	Uncharacterized protein	ISS	11532957	PubMed	PTHR10799:SF819	GLOBAL TRANSCRIPTION ACTIVATOR SNF2L1-RELATED
P00037	Ionotropic glutamate receptor pathway	P01026	KA	HUMAN|HGNC=4581|UniProtKB=Q13003	Glutamate receptor ionotropic, kainate 3	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00060	Ubiquitin proteasome pathway	P01491	E2	MONDO|Ensembl=ENSMODG00000010191|UniProtKB=F6SU17	Uncharacterized protein	ISS			PTHR43915:SF3	UBIQUITIN-CONJUGATING ENZYME E2 VARIANT 2
P00060	Ubiquitin proteasome pathway	P01491	E2	CANLF|Ensembl=ENSCAFG00000009745|UniProtKB=E2RN95	Uncharacterized protein	ISS			PTHR44189:SF1	UBIQUITIN-CONJUGATING ENZYME E2 C
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	SULSO|EnsemblGenome=SSO0242|UniProtKB=Q980P5	Adenylosuccinate synthetase	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00059	p53 pathway	P04616	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=98956|UniProtKB=P27467	Protein Wnt-3a	IDA	8717036	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	MOUSE|MGI=MGI=96616|UniProtKB=P26011	Integrin beta-7	ISS	3487386	PubMed	PTHR10082:SF36	INTEGRIN BETA-7
P00005	Angiogenesis	P00199	JNKK1	PANTR|Ensembl=ENSPTRG00000008783|UniProtKB=H2QCA7	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P02734	Chorismate biosynthesis	P02868	Chorismate synthase	YEAST|SGD=S000003116|UniProtKB=P28777	Chorismate synthase	ISS			PTHR21085:SF0	CHORISMATE SYNTHASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	TAKRU|Ensembl=ENSTRUG00000000584|UniProtKB=H2RMN2	Uncharacterized protein	IDA	11861492	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00048	PI3 kinase pathway	P01199	Galpha	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IC	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04393	Ras Pathway	P04552	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00021	FGF signaling pathway	P00640	PI3K	CANAL|CGD=CAL0068551|UniProtKB=Q5AAR9	Phosphatidylinositol 3-kinase	IGI	20330542	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00006	Apoptosis signaling pathway	P00319	TRADD	MACMU|Ensembl=ENSMMUG00000005908|UniProtKB=F6WWG3	Tumor necrosis factor receptor type 1-associated DEATH domain protein	ISS	10892748	PubMed	PTHR14913:SF0	TUMOR NECROSIS FACTOR RECEPTOR TYPE 1-ASSOCIATED DEATH DOMAIN PROTEIN
P00005	Angiogenesis	P00223	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1170702	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00045	Notch signaling pathway	P01099	Notch	HUMAN|HGNC=7881|UniProtKB=P46531	Neurogenic locus notch homolog protein 1	IGI	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06777	NFAT	MOUSE|MGI=MGI=103296|UniProtKB=P97305	Nuclear factor of activated T-cells, cytoplasmic 3	RCA	12787506	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00383	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	IDA	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	HUMAN|HGNC=5465|UniProtKB=P08069	Insulin-like growth factor 1 receptor	TAS	11182407	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00057	Wnt signaling pathway	P01438	PP2A	MOUSE|MGI=MGI=1349473|UniProtKB=Q61151	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	ISS	10092233	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DICDI|dictyBase=DDB_G0268622|UniProtKB=P34145	Rho-related protein rac1B	ISS	12932731	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DANRE|ZFIN=ZDB-GENE-040718-134|UniProtKB=Q6DH55	Guanine nucleotide binding protein (G protein), beta polypeptide 3, like	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00010	B cell activation	P00385	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	10891487	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P05918	p38 MAPK pathway	P06013	ELK	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	RCA	9644975	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	ANOGA|EnsemblGenome=AGAP005913|UniProtKB=Q7Q6D2	AGAP005913-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00029	Huntington disease	P00807	Actin	PHYIT|EnsemblGenome=PITG_15078|UniProtKB=D0NRL5	Actin-like protein	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00046	Oxidative stress response	P01131	MKP5	CANLF|Ensembl=ENSCAFG00000013641|UniProtKB=E2R7G4	Uncharacterized protein	ISS	11856337	PubMed	PTHR10159:SF299	DUAL SPECIFICITY PROTEIN PHOSPHATASE 10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CHICK|Ensembl=ENSGALG00000005123|UniProtKB=Q9DEB8	Protein Wnt	TAS	11266476	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00048	PI3 kinase pathway	P01188	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000006495|UniProtKB=P11017	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00007	Axon guidance mediated by semaphorins	P00331	PAK	MACMU|Ensembl=ENSMMUG00000001387|UniProtKB=F7D0B4	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01177	P110ACT	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	HUMAN|HGNC=4572|UniProtKB=P42262	Glutamate receptor 2	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00059	p53 pathway	G04694	p110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	MOUSE|MGI=MGI=95809|UniProtKB=P23819	Glutamate receptor 2	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	NEUCR|EnsemblGenome=EFNCRG00000004055|UniProtKB=Q1K7T9	Dihydrofolate synthetase	ISS			PTHR11136:SF0	DIHYDROFOLATE SYNTHETASE-RELATED
P00009	Axon guidance mediated by netrin	P00363	PI3K	DROME|FlyBase=FBgn0015278|UniProtKB=Q7K3H0	LD28067p	ISS	14526383	PubMed	PTHR10048:SF64	LD28067P
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01443	Phospholipase C	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=97614|UniProtKB=Q8R3B1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	10934033	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P06587	Nicotine pharmacodynamics pathway	P06604	SLC18A2	RAT|RGD=3694|UniProtKB=Q01827	Synaptic vesicular amine transporter	TAS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00005	Angiogenesis	P00236	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P06002	G-protein	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00965	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00564	Rac	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P06214	GBB signaling pathway	P06300	TKV	DROME|FlyBase=FBgn0003716|UniProtKB=Q9VMT1	Receptor protein serine/threonine kinase	TAS	9395284	PubMed	PTHR23255:SF68	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P04393	Ras Pathway	P04573	Elk-1	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	IDA	3183861	gi	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00029	Huntington disease	P00807	Actin	TAKRU|Ensembl=ENSTRUG00000005494|UniProtKB=P53483	Actin, alpha anomalous	IDA	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P02738	De novo purine biosynthesis	P02901	Adenosuccinate lyase	RAT|RGD=1307617|UniProtKB=D3ZW08	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00006	Apoptosis signaling pathway	P00274	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00778	NMDA receptor	MACMU|Ensembl=ENSMMUG00000016675|UniProtKB=F6VTB5	Uncharacterized protein	ISS	14698601	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00021	FGF signaling pathway	P00632	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IGI	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P05999	provasopressin	MACMU|Ensembl=ENSMMUG00000010678|UniProtKB=F7AXI7	Uncharacterized protein	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P02781	Threonine biosynthesis	P03190	Threonine synthase	ARATH|TAIR=AT4G29840|UniProtKB=Q9S7B5	Threonine synthase 1, chloroplastic	ISS			PTHR10314:SF5	THREONINE SYNTHASE 1, CHLOROPLASTIC
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	CAEEL|WormBase=WBGene00001985|UniProtKB=O02100	Presenilin hop-1	TAS	98004548	PubMed	PTHR10202:SF14	PRESENILIN HOP-1
P00048	PI3 kinase pathway	P01181	GSK3	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01093	AChE	RAT|RGD=619996|UniProtKB=Q9JKC1	Carboxylic ester hydrolase	IC			PTHR43918:SF5	CHOLINESTERASE
P00011	Blood coagulation	P00443	Fibrin polymer cross-linked	MACMU|Ensembl=ENSMMUG00000021302|UniProtKB=F6UZ87	Uncharacterized protein	ISS	223002	gi	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00048	PI3 kinase pathway	P01182	Ras	DICDI|dictyBase=DDB_G0292996|UniProtKB=P03967	Ras-like protein rasD	ISS	6091907	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00059	p53 pathway	P01486	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00563	Gab	RAT|RGD=1591402|UniProtKB=D4A779	Protein Phldb2	ISS			PTHR12156:SF21	PLECKSTRIN HOMOLOGY-LIKE DOMAIN FAMILY B MEMBER 2
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1354946|UniProtKB=Q61532	Mitogen-activated protein kinase 6	IDA	8444355	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00052	TGF-beta signaling pathway	P01275	P38	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	8925912	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00005	Angiogenesis	P00226	Delta/Serrate	PANTR|Ensembl=ENSPTRG00000013250|UniProtKB=H2QJZ0	Delta-like protein	ISS	10551863	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	MACMU|Ensembl=ENSMMUG00000022513|UniProtKB=F6YNZ0	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00049	Parkinson disease	P01227	20S proteasome	SCHPO|PomBase=SPBC646.16|UniProtKB=O94517	Probable proteasome subunit alpha type-1	TAS	12859888	PubMed	PTHR11599:SF11	PROTEASOME SUBUNIT ALPHA TYPE-6
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04393	Ras Pathway	P04556	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P06587	Nicotine pharmacodynamics pathway	P06602	PPP1CA	RAT|RGD=3375|UniProtKB=P62138	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit	ISS	8392016	PubMed	PTHR11668:SF377	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-ALPHA CATALYTIC SUBUNIT
P00006	Apoptosis signaling pathway	P00302	ATF	BOVIN|Ensembl=ENSBTAG00000002295|UniProtKB=F1N177	Uncharacterized protein	ISS	15218628	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P04393	Ras Pathway	P04566	Stat 1/3	PANTR|Ensembl=ENSPTRG00000009200|UniProtKB=H2QD20	Signal transducer and activator of transcription	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00048	PI3 kinase pathway	P01188	Gbetagamma	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01192	p110	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01320	PLC-gamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00019	Endothelin signaling pathway	P00577	PI3K	CAEEL|WormBase=WBGene00006932|UniProtKB=Q9TXI7	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00050	Plasminogen activating cascade	P01250	MMP-13	HUMAN|HGNC=7159|UniProtKB=P45452	Collagenase 3	IDA	12834808	PubMed	PTHR10201:SF165	COLLAGENASE 3
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	MACMU|Ensembl=ENSMMUG00000028733|UniProtKB=F6ZGX8	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF245	RAS-RELATED PROTEIN R-RAS
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PANTR|Ensembl=ENSPTRG00000018890|UniProtKB=Q5R1X3	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IDA	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	PANTR|Ensembl=ENSPTRG00000023608|UniProtKB=H2QZZ2	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	CANLF|Ensembl=ENSCAFG00000012353|UniProtKB=E2RSE6	Uncharacterized protein	ISS	11861638	PubMed	PTHR42884:SF1	FURIN
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	HUMAN|HGNC=14656|UniProtKB=Q8TD84	Down syndrome cell adhesion molecule-like protein 1	ISS			PTHR44107:SF3	DOWN SYNDROME CELL ADHESION MOLECULE-LIKE PROTEIN 1
P00010	B cell activation	P00383	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04372	5-Hydroxytryptamine degredation	P04401	Monoamine Oxidase	MOUSE|MGI=MGI=2140628|UniProtKB=B1ARV3	Amine oxidase [flavin-containing]	ISS			PTHR10742:SF355	AMINE OXIDASE  FLAVIN-CONTAINING
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IDA	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00029	Huntington disease	P00779	TBP	HUMAN|HGNC=11588|UniProtKB=P20226	TATA-box-binding protein	ISS	11988536	PubMed	PTHR10126:SF20	TATA-BOX-BINDING PROTEIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04393	Ras Pathway	P04559	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	HUMAN|HGNC=8592|UniProtKB=O75914	Serine/threonine-protein kinase PAK 3	ISS	11259591	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00219	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00629	PP2A	CANLF|Ensembl=ENSCAFG00000014047|UniProtKB=F1PV54	Uncharacterized protein	ISS	11531413	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01444	Wnt	BRAFL|Gene=BRAFLDRAFT_118309|UniProtKB=C3YZ17	Protein Wnt	IDA	11266476	PubMed	PTHR12027:SF100	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00238	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	3035212	PubMed	PTHR24070:SF385	GTPASE HRAS
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01440	Cadherin	CHICK|Gene=CDHR1|UniProtKB=Q8UVJ7	Cadherin-related family member 1	IDA	8120095	PubMed	PTHR44506:SF1	CADHERIN-RELATED FAMILY MEMBER 1
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00021	FGF signaling pathway	P00640	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	IGI	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P04398	p53 pathway feedback loops 2	P04658	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00054	Toll receptor signaling pathway	P01364	TPL2	CANLF|Ensembl=ENSCAFG00000003980|UniProtKB=E2RCV5	Uncharacterized protein	ISS	99133929	PubMed	PTHR24361:SF94	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 8
P00045	Notch signaling pathway	P01113	Pen-2	RAT|RGD=621060|UniProtKB=O88777	Presenilin-2	IEP	9332390	PubMed	PTHR10202:SF13	PRESENILIN-2
P02776	Serine glycine biosynthesis	P03160	Phosphoglycerate dehydrogenase	SYNY3|EnsemblGenome=BAA17878|UniProtKB=P73821	D-3-phosphoglycerate dehydrogenase	ISS			PTHR42938:SF9	FORMATE DEHYDROGENASE 1-RELATED
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	STRCO|Gene=CAC33054|UniProtKB=Q9AK37	Putative cytidine deaminase	ISS			PTHR11644:SF2	CYTIDINE DEAMINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	BOVIN|Ensembl=ENSBTAG00000003054|UniProtKB=F1MC23	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	CAEEL|WormBase=WBGene00004769|UniProtKB=P52166	Presenilin sel-12	TAS	7566091	PubMed	PTHR10202:SF13	PRESENILIN-2
P00034	Integrin signalling pathway	P00948	Rho	TAKRU|Ensembl=ENSTRUG00000011944|UniProtKB=H2TZX5	Uncharacterized protein	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P05918	p38 MAPK pathway	P05919	MAPKAP-K3	HUMAN|HGNC=6888|UniProtKB=Q16644	MAP kinase-activated protein kinase 3	ISS	11335727	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00206	Wnt	PANTR|Ensembl=ENSPTRG00000019617|UniProtKB=Q2QLE7	Protein Wnt-2	ISS	11266476	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00059	p53 pathway	P04630	PP2A	CANLF|Ensembl=ENSCAFG00000006453|UniProtKB=F6X958	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01199	Galpha	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IC	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	PANTR|Ensembl=ENSPTRG00000009822|UniProtKB=G2HEY4	Fibronectin 1	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	ISS	88318957	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00012	Cadherin signaling pathway	P00471	Cadherin	CAEEL|WormBase=WBGene00000396|UniProtKB=Q19319	Cadherin-4	IDA	8120095	PubMed	PTHR43956:SF7	CADHERIN-4
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	TAS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	MOUSE|MGI=MGI=894315|UniProtKB=Q99JI6	Ras-related protein Rap-1b	ISS	10476970	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IC	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00047	PDGF signaling pathway	P01162	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00049	Parkinson disease	P01219	SAPK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00034	Integrin signalling pathway	P00922	Collagen	PANTR|Ensembl=ENSPTRG00000000532|UniProtKB=H2PZI4	Uncharacterized protein	ISS	10778855	PubMed	PTHR44057:SF3	COLLAGEN ALPHA-2 VIII  CHAIN
P00034	Integrin signalling pathway	P00931	Integrin beta	PANTR|Ensembl=ENSPTRG00000013993|UniProtKB=Q5NKT5	Integrin beta	ISS	3487386	PubMed	PTHR10082:SF15	INTEGRIN BETA-2
P04392	P53 pathway feedback loops 1	P04539	p53	PANTR|Ensembl=ENSPTRG00000008703|UniProtKB=H2QC53	Cellular tumor antigen p53	ISS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	PANTR|Ensembl=ENSPTRG00000016154|UniProtKB=H2QPN2	C-X-C motif chemokine	ISS	124361	gi	PTHR10179:SF70	INTERLEUKIN-8
P00053	T cell activation	P01294	NFAT	RAT|RGD=1310749|UniProtKB=D3Z9H7	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	ISS	12015605	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P02751	Lysine biosynthesis	P03013	Aspartate semialdehyde dehydrogenase	ECOLI|EcoGene=EG11059|UniProtKB=P08390	USG-1 protein	ISS			PTHR10174:SF2	ASPARTATE-SEMIALDEHYDE DEHYDROGENASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00019	Endothelin signaling pathway	P00574	Big ET1-4	MOUSE|MGI=MGI=95284|UniProtKB=P22389	Endothelin-2	ISS			PTHR13874:SF9	ENDOTHELIN-2
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	CHICK|Ensembl=ENSGALG00000009405|UniProtKB=F1NKF1	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04586	ProTRH (Pro Thyrotropin-releasing Hormone)	BOVIN|Ensembl=ENSBTAG00000006295|UniProtKB=P01223	Thyrotropin subunit beta	ISS			PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	NAS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P06959	CCKR signaling map	P07233	MAP2K6	HUMAN|HGNC=6846|UniProtKB=P52564	Dual specificity mitogen-activated protein kinase kinase 6	RCA	9003778	PubMed	PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00012	Cadherin signaling pathway	P00470	F-actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	IC	3487386	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00004	Alzheimer disease-presenilin pathway	P00172	BACE-1	PANTR|Ensembl=ENSPTRG00000013924|UniProtKB=H2R1L7	Beta-site APP-cleaving enzyme 2	ISS			PTHR13683:SF262	BETA-SECRETASE 2
P00011	Blood coagulation	P00411	PAI-1	CANLF|Ensembl=ENSCAFG00000013909|UniProtKB=F1PUI4	Uncharacterized protein	ISS	1709561	gi	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04625	Cdk2	HUMAN|HGNC=1771|UniProtKB=P24941	Cyclin-dependent kinase 2	ISS	1846803	PubMed	PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01095	beta	MONDO|Ensembl=ENSMODG00000017165|UniProtKB=F6QDH4	Uncharacterized protein	ISS	22213672	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P00046	Oxidative stress response	P01135	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00564	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	10891487	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00021	FGF signaling pathway	P00635	FRS2	MACMU|Ensembl=ENSMMUG00000012417|UniProtKB=F7DJK6	Fibroblast growth factor receptor substrate 3	ISS			PTHR21258:SF39	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000014751|UniProtKB=H2R8D8	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	ORNAN|Ensembl=ENSOANG00000000493|UniProtKB=F7EPA8	Uncharacterized protein	ISS			PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00046	Oxidative stress response	P01132	c-jun	CHICK|Gene=JUN|UniProtKB=P18870	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05924	AT1-R	MOUSE|MGI=MGI=87964|UniProtKB=P29754	Type-1A angiotensin II receptor	RCA			PTHR24228:SF11	TYPE-1 ANGIOTENSIN II RECEPTOR
P00029	Huntington disease	P00772	FIP-2	HUMAN|HGNC=17142|UniProtKB=Q96CV9	Optineurin	TAS			PTHR31553:SF2	OPTINEURIN
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	STRCO|Gene=CAA20824|UniProtKB=O88070	Putative glutamine synthetase	ISS			PTHR43785:SF5	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00566	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00223	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PLAF7|EnsemblGenome=MAL13P1.148|UniProtKB=Q8IE50	Myosin C	IC			PTHR13140:SF706	UNCONVENTIONAL MYOSIN-VI
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	PANTR|Ensembl=ENSPTRG00000001756|UniProtKB=H2Q0Q7	Regulator of G-protein signaling 16	ISS	8756726	PubMed	PTHR10845:SF187	REGULATOR OF G-PROTEIN SIGNALING 16
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00019	Endothelin signaling pathway	P00566	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00034	Integrin signalling pathway	P00931	Integrin beta	MACMU|Ensembl=ENSMMUG00000003289|UniProtKB=F7FG54	Integrin beta	ISS	484963	gi	PTHR10082:SF25	INTEGRIN BETA-3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=3346|UniProtKB=P10688	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	12860966	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00057	Wnt signaling pathway	P01438	PP2A	SCHMA|EnsemblGenome=Smp_165490|UniProtKB=C1LZY9	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01223	UbcH8	MOUSE|MGI=MGI=1914500|UniProtKB=Q9QZU9	Ubiquitin/ISG15-conjugating enzyme E2 L6	IDA	11078524	PubMed	PTHR24068:SF43	UBIQUITIN/ISG15-CONJUGATING ENZYME E2 L6
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00990	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00243	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00019	Endothelin signaling pathway	P00584	Gs	BOVIN|Ensembl=ENSBTAG00000002125|UniProtKB=F1N461	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00146	Afadin	HUMAN|HGNC=7137|UniProtKB=P55196	Afadin	ISS	10974003	PubMed	PTHR10398:SF1	AFADIN
P06959	CCKR signaling map	G06969	HDC	HUMAN|HGNC=4855|UniProtKB=P19113	Histidine decarboxylase	RCA		PubMed	PTHR11999:SF68	HISTIDINE DECARBOXYLASE
P00021	FGF signaling pathway	P00623	FGF	ORNAN|Ensembl=ENSOANG00000014242|UniProtKB=F6WG78	Fibroblast growth factor	ISS	12799194	PubMed	PTHR11486:SF86	FIBROBLAST GROWTH FACTOR 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00036	Interleukin signaling pathway	P00996	STAT	MACMU|Ensembl=ENSMMUG00000010705|UniProtKB=F7G8V4	Signal transducer and activator of transcription	ISS	96210005	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P04393	Ras Pathway	P04572	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00006	Apoptosis signaling pathway	P00302	ATF	BOVIN|Ensembl=ENSBTAG00000002295|UniProtKB=F1N177	Uncharacterized protein	ISS	7875593	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IDA	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00047	PDGF signaling pathway	P01154	Ras	DICDI|dictyBase=DDB_G0281385|UniProtKB=P32253	Ras-like protein rasC	ISS	94119591	PubMed	PTHR24070:SF251	RAS-LIKE PROTEIN RASC
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	CHICK|Ensembl=ENSGALG00000011905|UniProtKB=F1NHT7	Uncharacterized protein	IDA	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P00049	Parkinson disease	P01219	SAPK	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	NAS	8925912	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00005	Angiogenesis	P00206	Wnt	CIOIN|Ensembl=ENSCING00000000407|UniProtKB=Q9U6V0	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF77	PROTEIN WNT-5
P02747	Histidine biosynthesis	P02991	Histidinephosphate aminotransferase	MYCTU|EnsemblGenome=Rv2231c|UniProtKB=P9WQ89	Uncharacterized aminotransferase Rv2231c	ISS			PTHR42885:SF1	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01292	RSmads	DANRE|ZFIN=ZDB-GENE-990603-7|UniProtKB=Q9I9P9	Mothers against decapentaplegic homolog 2	TAS	9395284	PubMed	PTHR13703:SF42	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 2
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01330	IKK	BOVIN|Ensembl=ENSBTAG00000007591|UniProtKB=Q95KV1	Inhibitor of nuclear factor kappa-B kinase subunit alpha	IGI	12235208	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	DROME|FlyBase=FBgn0030384|UniProtKB=Q9VYN5	AT26486p	ISS	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	MACMU|Ensembl=ENSMMUG00000022936|UniProtKB=F6U709	Uncharacterized protein	ISS	11861492	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00010	B cell activation	P00402	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	88241036	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00005	Angiogenesis	P00226	Delta/Serrate	RAT|RGD=70949|UniProtKB=P97677	Delta-like protein 1	ISS	12175503	PubMed	PTHR24044:SF380	DELTA-LIKE PROTEIN 1
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00507	Rho	MOUSE|MGI=MGI=106028|UniProtKB=Q62159	Rho-related GTP-binding protein RhoC	ISS	12090470	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8659|UniProtKB=O60245	Protocadherin-7	IDA	8120095	PubMed	PTHR43912:SF8	PROTOCADHERIN-7
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	HUMAN|HGNC=6903|UniProtKB=Q00266	S-adenosylmethionine synthase isoform type-1	ISS			PTHR11964:SF11	S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Ensembl=ENSBTAG00000013202|UniProtKB=Q1RML2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1	ISS	15611108	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000018059|UniProtKB=C7G3M9	Glutamate receptor, metabotropic 4	ISS	11431030	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	PLAF7|EnsemblGenome=PF14_0100|UniProtKB=Q8ILZ3	CTP synthase	ISS			PTHR11550:SF0	CTP SYNTHASE
P00036	Interleukin signaling pathway	P00973	PKB	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00218	STAT1	TAKRU|Ensembl=ENSTRUG00000000102|UniProtKB=H2RJA9	Signal transducer and activator of transcription	ISS	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00034	Integrin signalling pathway	P00907	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00012	Cadherin signaling pathway	P00470	F-actin	STRPU|EnsemblGenome=SPU_012282|UniProtKB=W4Y969	Uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF369	ACTIN-42A
P00059	p53 pathway	P04630	PP2A	PANTR|Ensembl=ENSPTRG00000017238|UniProtKB=H2QRH7	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PANTR|Gene=TUBB8|UniProtKB=Q8WP14	Tubulin beta-8 chain	ISS	12932731	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00206	Wnt	CANLF|Ensembl=ENSCAFG00000008760|UniProtKB=E2RTG8	Protein Wnt	ISS	14644163	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P06587	Nicotine pharmacodynamics pathway	P06606	ADCY2	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P02752	Mannose metabolism	P03021	GDP Mannose 6-dehydrogenase	STRCO|Gene=CAB58323|UniProtKB=Q9RJK6	UDP-glucose/GDP-mannose family dehydrogenase (Putative secreted protein)	TAS	12000953	PubMed	PTHR43750:SF1	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P02771	Pyrimidine Metabolism	P03128	Dihydrouracil Dehydrogenase	MACMU|Ensembl=ENSMMUG00000020726|UniProtKB=F7GVE2	Uncharacterized protein	ISS	1512248	PubMed	PTHR43073:SF2	DIHYDROPYRIMIDINE DEHYDROGENASE  NADP +
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MOUSE|MGI=MGI=102806|UniProtKB=P27038	Activin receptor type-2A	TAS	9395284	PubMed	PTHR23255:SF64	ACTIVIN RECEPTOR TYPE-2A
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	CAEEL|WormBase=WBGene00004287|UniProtKB=Q94124	Ras-related protein rac-2	ISS	12932731	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00053	T cell activation	P01311	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IDA	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00562	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IGI	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00051	TCA cycle	P01274	Succinyl CoA Synthetase	TRIVA|Gene=TVAG_318670|UniProtKB=O15568	Adhesin protein AP33-1	IDA	7808480	PubMed	PTHR11117:SF2	SUCCINYL-COA LIGASE  ADP/GDP-FORMING  SUBUNIT ALPHA, MITOCHONDRIAL
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MOUSE|MGI=MGI=1351339|UniProtKB=Q14BI2	Metabotropic glutamate receptor 2	ISS			PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00047	PDGF signaling pathway	P01143	ERK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS			PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00760	Gtalpha	MOUSE|MGI=MGI=95778|UniProtKB=P20612	Guanine nucleotide-binding protein G(t) subunit alpha-1	IDA	6264430	PubMed	PTHR10218:SF67	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-1
P00049	Parkinson disease	P01211	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IGI	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00034	Integrin signalling pathway	P00907	ERK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS			PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	RAT|RGD=2742|UniProtKB=P23385	Metabotropic glutamate receptor 1	IDA	14614461	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00016	Cytoskeletal regulation by Rho GTPase	P00520	Rho GAPs	BOVIN|Ensembl=ENSBTAG00000016501|UniProtKB=F6RWK1	Uncharacterized protein	ISS	14724572	PubMed	PTHR23176:SF28	RHO GTPASE-ACTIVATING PROTEIN 1
P00049	Parkinson disease	P01211	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10755300	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	DANRE|ZFIN=ZDB-GENE-030131-7595|UniProtKB=Q6PBR4	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00047	PDGF signaling pathway	P01154	Ras	DAPPU|EnsemblGenome=DAPPUDRAFT_301818|UniProtKB=E9I1I7	Putative uncharacterized protein	ISS	20148920	PubMed	PTHR24070:SF385	GTPASE HRAS
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00034	Integrin signalling pathway	P00925	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IDA	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02771	Pyrimidine Metabolism	P03126	Nucleoside Phosphorylase	ECOLI|EcoGene=EG10219|UniProtKB=P07650	Thymidine phosphorylase	ISS	11206551	PubMed	PTHR10515:SF0	THYMIDINE PHOSPHORYLASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00051	TCA cycle	P01269	alphaketoglutarate Dehydrogenase	HUMAN|HGNC=8124|UniProtKB=Q02218	2-oxoglutarate dehydrogenase, mitochondrial	IEA	12477932	PubMed	PTHR23152:SF7	2-OXOGLUTARATE DEHYDROGENASE, MITOCHONDRIAL
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	HALSA|EnsemblGenome=VNG_1160G|UniProtKB=P61136	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00049	Parkinson disease	P01211	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	CAEEL|WormBase=WBGene00006390|UniProtKB=Q7YTH5	TAF (TBP-associated transcription factor) family	ISS	604904	OMIM	PTHR12321:SF78	TAF  TBP-ASSOCIATED TRANSCRIPTION FACTOR  FAMILY
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00057	Wnt signaling pathway	P01472	Histone deacetylase	PANTR|Ensembl=ENSPTRG00000039785|UniProtKB=H2RGL2	Histone deacetylase	ISS	12665570	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P00021	FGF signaling pathway	P00623	FGF	BOVIN|Ensembl=ENSBTAG00000019241|UniProtKB=E1B753	Fibroblast growth factor	ISS	8790420	PubMed	PTHR11486:SF67	FIBROBLAST GROWTH FACTOR 11
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	TAS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00048	PI3 kinase pathway	P01179	PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00034	Integrin signalling pathway	P00907	ERK	MACMU|Ensembl=ENSMMUG00000016376|UniProtKB=F7G2W1	Uncharacterized protein	ISS			PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	RAT|RGD=1311192|UniProtKB=A0A0G2K3R1	Protein Map3k4	ISS	10207617	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	RAT|RGD=1309142|UniProtKB=D3ZGB1	Nuclear factor of activated T-cells 5	ISS			PTHR12533:SF10	NUCLEAR FACTOR OF ACTIVATED T-CELLS 5
P00038	JAK/STAT signaling pathway	P01027	STAT	PANTR|Ensembl=ENSPTRG00000009200|UniProtKB=H2QD20	Signal transducer and activator of transcription	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	DANRE|ZFIN=ZDB-GENE-980526-527|UniProtKB=B3DJ37	Receptor protein serine/threonine kinase	IDA			PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P00030	Hypoxia response via HIF activation	P00824	PTEN	XENTR|Xenbase=XB-GENE-491433|UniProtKB=B1H2U0	Pten protein	ISS	10555148	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CAEBR|Gene=CBG18256|UniProtKB=A8XS95	Protein CBR-ACT-5	ISS	10974003	PubMed	PTHR11937:SF352	ACTIN
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P06587	Nicotine pharmacodynamics pathway	P06601	FLNA	RAT|RGD=1560614|UniProtKB=C0JPT7	Filamin alpha	ISS	9722563	PubMed	PTHR43998:SF6	FILAMIN-A
P00046	Oxidative stress response	P01121	MKK3/6	RAT|RGD=1306620|UniProtKB=B1H230	Map2k3 protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01080	AChE	PANTR|Ensembl=ENSPTRG00000019514|UniProtKB=H2R3Y8	Carboxylic ester hydrolase	ISS	87080761	PubMed	PTHR11559:SF356	ACETYLCHOLINESTERASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	PANTR|Ensembl=ENSPTRG00000010386|UniProtKB=H2QF61	Tyrosine-protein kinase receptor	ISS	11182407	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00047	PDGF signaling pathway	P01145	c-fos	CANLF|Ensembl=ENSCAFG00000017040|UniProtKB=E2QYK5	Uncharacterized protein	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00005	Angiogenesis	P00249	PAK	RAT|RGD=3250|UniProtKB=P35465	Serine/threonine-protein kinase PAK 1	ISS	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00013	Cell cycle	P00480	Proteasome	ORYSJ|EnsemblGenome=OS05G0371200|UniProtKB=Q60EW3	Os05g0371200 protein	ISS	15237785	gi	PTHR10410:SF5	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 14
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P02738	De novo purine biosynthesis	P02909	GDP reductase	CAEBR|Gene=CBG10154|UniProtKB=A8XAI1	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MACMU|Ensembl=ENSMMUG00000008845|UniProtKB=P48094	Tumor necrosis factor	ISS	11911478	PubMed	PTHR11471:SF23	TUMOR NECROSIS FACTOR
P00017	DNA replication	P00535	5' to 3' Exoribonulcease	SCHPO|PomBase=SPAC17A5.14|UniProtKB=P40383	5'-3' exoribonuclease 1	ISS	21848401	PubMed	PTHR12341:SF7	5'-3' EXORIBONUCLEASE 1
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	TAS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04393	Ras Pathway	P04566	Stat 1/3	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	IDA	12461178	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	PANTR|Ensembl=ENSPTRG00000018624|UniProtKB=A6H914	TATA box binding protein-like 1	ISS	10082669	PubMed	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IDA	10395542	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	MOUSE|MGI=MGI=108007|UniProtKB=P48543	G protein-activated inward rectifier potassium channel 3	ISS	2433589	PubMed	PTHR11767:SF17	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 3
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	IC	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00054	Toll receptor signaling pathway	P01338	IkappaB	CHICK|Gene=NFKBIA|UniProtKB=Q91974	NF-kappa-B inhibitor alpha	ISS	14665694	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00057	Wnt signaling pathway	P01438	PP2A	SCHPO|PomBase=SPAC6F12.12|UniProtKB=P78759	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta 2 isoform	ISS	10092233	PubMed	PTHR10257:SF3	PP2A-B', ISOFORM B
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00005	Angiogenesis	P00193	SOS-1	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IDA	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00035	Interferon-gamma signaling pathway	P00960	PTP	MONDO|Ensembl=ENSMODG00000003120|UniProtKB=F6WVD2	Tyrosine-protein phosphatase non-receptor type	ISS	95163101	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ENTHI|EnsemblGenome=EHI_107290|UniProtKB=B1N2P0	Actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00029	Huntington disease	P00786	ARF	CAEBR|Gene=CBG17727|UniProtKB=A8XRF4	Protein CBR-ARF-3	ISS	12932731	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00018	EGF receptor signaling pathway	P00547	PP2A	RAT|RGD=6503701|UniProtKB=F1MAA3	Protein LOC100909464	ISS	12110603	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	CAEEL|WormBase=WBGene00004924|UniProtKB=P91493	SyNapTotagmin	ISS			PTHR10024:SF218	FI18813P1
P00053	T cell activation	P01316	MHC-antigen	MACMU|Gene=B2M|UniProtKB=Q6V7J5	Beta-2-microglobulin	ISS			PTHR19944:SF62	BETA-2-MICROGLOBULIN
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00005	Angiogenesis	P00191	TF	MOUSE|MGI=MGI=88381|UniProtKB=P20352	Tissue factor	ISS	31560592	gi	PTHR20859:SF22	TISSUE FACTOR
P00049	Parkinson disease	P01215	Syntaxin	BOVIN|Ensembl=ENSBTAG00000017139|UniProtKB=Q3ZBT5	Syntaxin-7	ISS	10321247	PubMed	PTHR19957:SF90	SYNTAXIN-7
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04393	Ras Pathway	P04552	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00049	Parkinson disease	P01208	Hsp70	RAT|RGD=2840|UniProtKB=P0DMW1	Heat shock 70 kDa protein 1B	IDA	12150907	PubMed	PTHR19375:SF223	HEAT SHOCK 70 KDA PROTEIN 1A-RELATED
P00034	Integrin signalling pathway	P00907	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	BOVIN|Gene=CACNB1|UniProtKB=Q9MZL7	Voltage-dependent L-type calcium channel subunit beta-1	IDA	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000014751|UniProtKB=H2R8D8	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8656|UniProtKB=Q9BZA7	Protocadherin-11 X-linked	IDA	8120095	PubMed	PTHR43912:SF1	PROTOCADHERIN-11 X-LINKED-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	CHICK|Ensembl=ENSGALG00000027629|UniProtKB=Q5ZJ03	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00057	Wnt signaling pathway	P01453	Ebi	RAT|RGD=1560053|UniProtKB=D3ZNF4	Protein Tbl1xr1	ISS	11389839	PubMed	PTHR22846:SF40	F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN TBL1XR1
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01142	p90RSK	RAT|RGD=1563860|UniProtKB=D3Z8E0	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P05917	Opioid proopiomelanocortin pathway	P06009	K+ channel	HUMAN|HGNC=6278|UniProtKB=O14649	Potassium channel subfamily K member 3	ISS	11875121	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00005	Angiogenesis	P00203	Erk	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01154	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CAEEL|WormBase=WBGene00009595|UniProtKB=Q7JMS5	Uncharacterized protein	TAS	10769018	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P05726	2-arachidonoylglycerol biosynthesis	P05735	PLA1	RAT|RGD=621261|UniProtKB=P97535	Phospholipase A1 member A	ISS			PTHR11610:SF111	PHOSPHOLIPASE A1 MEMBER A
P00004	Alzheimer disease-presenilin pathway	P00114	actin	RAT|RGD=1304556|UniProtKB=P63259	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P05913	Enkephalin release	P05974	G-Protein (i)	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	HUMAN|HGNC=4581|UniProtKB=Q13003	Glutamate receptor ionotropic, kainate 3	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	TAS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00005	Angiogenesis	P00193	SOS-1	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	9094314	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00036	Interleukin signaling pathway	P00973	PKB	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05730	Endogenous cannabinoid signaling	P05746	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	TAS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	TAS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05916	Opioid prodynorphin pathway	P06002	G-protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	8327893	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P02788	Xanthine and guanine salvage pathway	P03250	Guanosine phosphorylase	CAEEL|WormBase=WBGene00019298|UniProtKB=U4PSA1	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00010	B cell activation	P00392	I kappa B	MOUSE|MGI=MGI=104741|UniProtKB=Q9Z1E3	NF-kappa-B inhibitor alpha	ISS	99081292	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00018	EGF receptor signaling pathway	G01511	SPRY	HUMAN|HGNC=11271|UniProtKB=O43610	Protein sprouty homolog 3	ISS			PTHR12365:SF9	PROTEIN SPROUTY HOMOLOG 3
P00012	Cadherin signaling pathway	P00470	F-actin	XENTR|Xenbase=XB-GENE-493937|UniProtKB=Q5M8T9	Actin, alpha 2, smooth muscle, aorta	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CANLF|Ensembl=ENSCAFG00000002617|UniProtKB=E2QUL1	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00036	Interleukin signaling pathway	P00976	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=98959|UniProtKB=P22726	Protein Wnt-5b	IDA	11266476	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00019	Endothelin signaling pathway	P00590	IP3 R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DROME|FlyBase=FBgn0000045|UniProtKB=P02574	Actin, larval muscle	IDA	11889126	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	TRYB2|Gene=Tb11.02.2740|UniProtKB=Q385Q9	Aspartate aminotransferase, mitochondrial	ISS			PTHR11879:SF10	ASPARTATE AMINOTRANSFERASE
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	DICPU|Gene=DICPUDRAFT_51488|UniProtKB=F1A411	Putative uncharacterized protein rasC	ISS	94119591	PubMed	PTHR24070:SF251	RAS-LIKE PROTEIN RASC
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00019	Endothelin signaling pathway	P00580	ET-RA/B	RAT|RGD=2535|UniProtKB=P26684	Endothelin-1 receptor	IPI	91195317	PubMed	PTHR24243:SF31	ENDOTHELIN-1 RECEPTOR
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	IC	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00018	EGF receptor signaling pathway	P00558	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	BOVIN|Gene=PCSK2|UniProtKB=Q9GLR0	Neuroendocrine convertase 2	IDA			PTHR42884:SF13	NEUROENDOCRINE CONVERTASE 2
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	14526383	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00019	Endothelin signaling pathway	P00568	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	IDA	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P06587	Nicotine pharmacodynamics pathway	P06595	CHRNA3	HUMAN|HGNC=1957|UniProtKB=P32297	Neuronal acetylcholine receptor subunit alpha-3	IDA	85270494	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00034	Integrin signalling pathway	P00923	Arf1	SCHPO|PomBase=SPBC4F6.18c|UniProtKB=P36579	ADP-ribosylation factor 1	IPI	12932731	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=96276|UniProtKB=Q61224	5-hydroxytryptamine receptor 1D	IDA	14645495	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00018	EGF receptor signaling pathway	P00560	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01131	MKP5	CAEEL|WormBase=WBGene00009142|UniProtKB=Q93592	Uncharacterized protein	ISS			PTHR10159:SF492	SUBFAMILY NOT NAMED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	IC	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05977	G-Protein (s)	CHICK|Ensembl=ENSGALG00000007509|UniProtKB=F1NM72	Uncharacterized protein	ISS	6309844	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04393	Ras Pathway	P04555	PDK	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	IDA	9094314	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=88355|UniProtKB=P15116	Cadherin-2	IDA	8120095	PubMed	PTHR24027:SF79	CADHERIN-2
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	PANTR|Ensembl=ENSPTRG00000000387|UniProtKB=H2PYE3	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MOUSE|MGI=MGI=1346876|UniProtKB=O35099	Mitogen-activated protein kinase kinase kinase 5	ISS	11730323	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MOUSE|MGI=MGI=3710243|UniProtKB=A2AQP0	Myosin-7B	ISS	89264452	PubMed	PTHR13140:SF358	MYOSIN-7B
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00774	Dynein complex	HUMAN|HGNC=18661|UniProtKB=Q8WXX0	Dynein heavy chain 7, axonemal	IPI	9454836	PubMed	PTHR10676:SF310	DYNEIN HEAVY CHAIN 7, AXONEMAL
P00018	EGF receptor signaling pathway	P00546	GAP	RAT|RGD=621686|UniProtKB=Q6P730	Disabled homolog 2-interacting protein	ISS	14735459	gi	PTHR10194:SF26	DISABLED HOMOLOG 2-INTERACTING PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	ARATH|TAIR=AT1G08700|UniProtKB=O64668	Presenilin-like protein At1g08700	TAS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	MACMU|Ensembl=ENSMMUG00000017654|UniProtKB=F6UI32	Beta-arrestin-2 isoform 1	ISS	4757780	gi	PTHR11792:SF20	BETA-ARRESTIN-2
P00019	Endothelin signaling pathway	P00568	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00034	Integrin signalling pathway	P00927	Rac	ENTHI|EnsemblGenome=EHI_129750|UniProtKB=C4M5Q7	Rho family GTPase	IGI	9601102	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00048	PI3 kinase pathway	P01185	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00048	PI3 kinase pathway	P01176	JAK	MONDO|Ensembl=ENSMODG00000015373|UniProtKB=F6WH53	Tyrosine-protein kinase	ISS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00057	Wnt signaling pathway	P01438	PP2A	RAT|RGD=3381|UniProtKB=P62716	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00543	ERK1-2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04557	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00013	Cell cycle	P00480	Proteasome	CANLF|Ensembl=ENSCAFG00000012565|UniProtKB=F1PRW0	Uncharacterized protein	ISS	11827521	PubMed	PTHR10223:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4
P00005	Angiogenesis	P00236	PI3K	ANOGA|Gene=AgaP_AGAP010273|UniProtKB=Q7PMF0	Phosphatidylinositol 3-kinase	ISS			PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00005	Angiogenesis	P00193	SOS-1	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00036	Interleukin signaling pathway	P00981	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	TAS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MONDO|Ensembl=ENSMODG00000023942|UniProtKB=F7F878	Uncharacterized protein	ISS	12441358	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	13620175	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00023	General transcription regulation	P00658	TBP-associated factors	CAEEL|WormBase=WBGene00006390|UniProtKB=Q7YTH5	TAF (TBP-associated transcription factor) family	ISS	604905	OMIM	PTHR12321:SF78	TAF  TBP-ASSOCIATED TRANSCRIPTION FACTOR  FAMILY
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CAEEL|WormBase=WBGene00000067|UniProtKB=O45815	ACTin	IC	10974003	PubMed	PTHR11937:SF352	ACTIN
P00048	PI3 kinase pathway	P01182	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P05730	Endogenous cannabinoid signaling	P05748	mGluR	HUMAN|HGNC=4593|UniProtKB=Q13255	Metabotropic glutamate receptor 1	ISS	12351712	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00016	Cytoskeletal regulation by Rho GTPase	P00520	Rho GAPs	PANTR|Ensembl=ENSPTRG00000003550|UniProtKB=H2Q3I0	Rho GTPase activating protein 1	ISS	14724572	PubMed	PTHR23176:SF28	RHO GTPASE-ACTIVATING PROTEIN 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	DROME|FlyBase=FBgn0000064|UniProtKB=P07764	Fructose-bisphosphate aldolase	NAS	96063611	PubMed	PTHR11627:SF20	FRUCTOSE-BISPHOSPHATE ALDOLASE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	BOVIN|Ensembl=ENSBTAG00000047202|UniProtKB=G3N3K3	Uncharacterized protein	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00053	T cell activation	P01318	PKC-theta	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00627	ERK1-2	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	IGI	94131270	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00021	FGF signaling pathway	P00632	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00011	Blood coagulation	P00415	Plasmin	BOVIN|Gene=PLG|UniProtKB=P06868	Plasminogen	ISS	85203906	PubMed	PTHR24261:SF5	PLASMINOGEN
P00046	Oxidative stress response	P01135	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	TAS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000017346|UniProtKB=Q5DRB3	Protocadherin gamma-A7	ISS	8120095	PubMed	PTHR24028:SF56	PROTOCADHERIN GAMMA-A7
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MACMU|Ensembl=ENSMMUG00000014807|UniProtKB=F6W548	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_127490|UniProtKB=C3XYC5	Putative uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P05915	Opioid proenkephalin pathway	P05994	G-protein	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00021	FGF signaling pathway	P00632	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00237	FRP	PANTR|Ensembl=ENSPTRG00000028511|UniProtKB=H2R570	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF81	FRIZZLED-1
P00036	Interleukin signaling pathway	P00974	Receptor subunit beta	PANTR|Gene=CXCR2|UniProtKB=Q28807	C-X-C chemokine receptor type 2 (Fragment)	ISS	10741397	PubMed	PTHR10489:SF689	C-X-C CHEMOKINE RECEPTOR TYPE 2
P05918	p38 MAPK pathway	P06041	Cdc42	DANRE|ZFIN=ZDB-GENE-030131-8783|UniProtKB=Q52WY2	Ras-like protein Cdc42a	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04396	Vitamin D metabolism and pathway	P04600	DBP	HUMAN|HGNC=4187|UniProtKB=P02774	Vitamin D-binding protein	IPI	11799400	PubMed	PTHR11385:SF11	VITAMIN D-BINDING PROTEIN
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IGI	10395542	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	YEAST|SGD=S000001855|UniProtKB=P60010	Actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00030	Hypoxia response via HIF activation	P00823	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00049	Parkinson disease	P01235	Fyn kinase	XENTR|Xenbase=XB-GENE-6053489|UniProtKB=F6S8L5	Tyrosine-protein kinase	ISS	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00010	B cell activation	P00397	IKK	MOUSE|MGI=MGI=1338071|UniProtKB=O88351	Inhibitor of nuclear factor kappa-B kinase subunit beta	IGI	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00010	B cell activation	P00375	Calmodulin	MOUSE|MGI=MGI=103249|UniProtKB=P62204	Calmodulin	ISS	7514101	PubMed	PTHR23050:SF311	CALMODULIN
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	YEAST|SGD=S000005738|UniProtKB=P18851	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8972|UniProtKB=O00750	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CAEBR|Gene=CBG03476|UniProtKB=A8WV58	Protein CBR-EGL-20	ISS	11266476	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P00034	Integrin signalling pathway	P00907	ERK	MACMU|Ensembl=ENSMMUG00000018568|UniProtKB=F6YLW2	Uncharacterized protein	ISS			PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	129387	gi	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00019	Endothelin signaling pathway	P00590	IP3 R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05913	Enkephalin release	P05974	G-Protein (i)	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CHICK|Ensembl=ENSGALG00000014182|UniProtKB=O13076	Adenosine receptor A2b	IDA			PTHR24246:SF18	ADENOSINE RECEPTOR A2B
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00053	T cell activation	P01298	NFkappaB	HUMAN|HGNC=7795|UniProtKB=Q00653	Nuclear factor NF-kappa-B p100 subunit	IGI	9133421	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00049	Parkinson disease	P01208	Hsp70	TRYB2|Gene=Tb11.01.3080|UniProtKB=Q383E9	Heat shock protein 70, putative	IDA	12150907	PubMed	PTHR19375:SF256	HSP70 PROTEIN-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04585	TRH	CANLF|Gene=CGA|UniProtKB=Q9XSW8	Glycoprotein hormones alpha chain	ISS			PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P00048	PI3 kinase pathway	P01206	14-3-3	CAEBR|Gene=CBG17289|UniProtKB=A8XQR9	14-3-3 zeta	ISS	97315111	PubMed	PTHR18860:SF13	14-3-3 PROTEIN ZETA
P00057	Wnt signaling pathway	P01435	SWI/SNF	MOUSE|MGI=MGI=1203524|UniProtKB=P97496	SWI/SNF complex subunit SMARCC1	IDA	11532957	PubMed	PTHR12802:SF9	SWI/SNF COMPLEX SUBUNIT SMARCC1
P02734	Chorismate biosynthesis	P02869	3-Dehydroquinate dehydratase	BACSU|EnsemblGenome=BSU23080|UniProtKB=P35146	3-dehydroquinate dehydratase	ISS			PTHR43699:SF1	3-DEHYDROQUINATE DEHYDRATASE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	97102671	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00049	Parkinson disease	P01226	CDCrel-1	MACMU|Ensembl=ENSMMUG00000004736|UniProtKB=F6R3X6	Septin-2	ISS			PTHR18884:SF67	SEPTIN-2
P00025	Hedgehog signaling pathway	P00697	Sap18	ARATH|TAIR=AT2G45640|UniProtKB=O64644	Histone deacetylase complex subunit SAP18	ISS			PTHR13082:SF0	HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	CHICK|Ensembl=ENSGALG00000005998|UniProtKB=Q5ZIW8	Uncharacterized protein	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00046	Oxidative stress response	P01122	TRX	HUMAN|HGNC=12435|UniProtKB=P10599	Thioredoxin	TAS	12115731	PubMed	PTHR10438:SF18	THIOREDOXIN
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ORYSJ|EnsemblGenome=OS06G0600100|UniProtKB=Q69X47	Os06g0600100 protein	ISS			PTHR23073:SF12	26S PROTEASE REGULATORY SUBUNIT 8
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	IXOSC|EnsemblGenome=ISCW024111|UniProtKB=B7PBG2	Actin, putative (Fragment)	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02748	Isoleucine biosynthesis	P02994	Branched chain amino acid aminotransferase	DEIRA|EnsemblGenome=DR_1626|UniProtKB=Q9RTX5	Branched-chain-amino-acid aminotransferase	ISS			PTHR42825:SF2	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 3, CHLOROPLASTIC
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00029	Huntington disease	P00805	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00046	Oxidative stress response	P01131	MKP5	MACMU|Ensembl=ENSMMUG00000008094|UniProtKB=F7HKX4	Dual specificity protein phosphatase	ISS			PTHR10159:SF111	DUAL SPECIFICITY PROTEIN PHOSPHATASE 4
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	IDA	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05730	Endogenous cannabinoid signaling	P05746	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CANLF|Ensembl=ENSCAFG00000002617|UniProtKB=E2QUL1	Uncharacterized protein	ISS	11554549	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00013	Cell cycle	P00480	Proteasome	MOUSE|MGI=MGI=98858|UniProtKB=P14685	26S proteasome non-ATPase regulatory subunit 3	TAS	2568889	PubMed	PTHR10758:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00021	FGF signaling pathway	P00643	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00005	Angiogenesis	P00243	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	P01435	SWI/SNF	PANTR|Ensembl=ENSPTRG00000015511|UniProtKB=H2R3U6	Helicase-like transcription factor	ISS	11532957	PubMed	PTHR10799:SF870	HELICASE-LIKE TRANSCRIPTION FACTOR
P00018	EGF receptor signaling pathway	P00561	STAT	TAKRU|Ensembl=ENSTRUG00000000102|UniProtKB=H2RJA9	Signal transducer and activator of transcription	ISS	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CANLF|Ensembl=ENSCAFG00000028654|UniProtKB=J9P702	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00048	PI3 kinase pathway	P01192	p110	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01151	PKB	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00566	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	MACMU|Ensembl=ENSMMUG00000005530|UniProtKB=F7GFB1	Synaptotagmin I	ISS	11438518	PubMed	PTHR10024:SF239	SYNAPTOTAGMIN-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00009	Axon guidance mediated by netrin	P00363	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00047	PDGF signaling pathway	P01153	GSK3	BOVIN|Ensembl=ENSBTAG00000020756|UniProtKB=A6QLB8	GSK3A protein	ISS	14698990	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	TAS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00049	Parkinson disease	P01207	PLD2	BOVIN|Gene=PLD2|UniProtKB=Q0V8L6	Phospholipase D2	ISS	15030398	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DICDI|dictyBase=DDB_G0283907|UniProtKB=P34099	cAMP-dependent protein kinase catalytic subunit	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P05730	Endogenous cannabinoid signaling	P05748	mGluR	MACMU|Ensembl=ENSMMUG00000016428|UniProtKB=F7GU00	Metabotropic glutamate receptor 1 isoform alpha	ISS	12351712	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	ANOGA|EnsemblGenome=AGAP001506|UniProtKB=Q7PXP3	AGAP001506-PA	IC			PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	ISS	88234494	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	RCA	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=1935205|UniProtKB=Q91XW9	MCG133388, isoform CRA_f	IDA	8120095	PubMed	PTHR24028:SF234	PROTOCADHERIN GAMMA-C5
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000003399|UniProtKB=H2Q383	Phosphoinositide-3-kinase, class 2, alpha polypeptide	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	IC	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CANLF|Ensembl=ENSCAFG00000009967|UniProtKB=F1PGZ2	Muscarinic acetylcholine receptor	ISS	8100450	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BOVIN|Gene=ACTB|UniProtKB=P60712	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00036	Interleukin signaling pathway	P00977	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00036	Interleukin signaling pathway	P00964	p90RSK	BOVIN|Ensembl=ENSBTAG00000014447|UniProtKB=A4IFF4	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=1921305|UniProtKB=Q8K4S1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	12860966	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00053	T cell activation	P01300	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT1G10210|UniProtKB=Q39021	Mitogen-activated protein kinase 1	IDA	9836510	gi	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P02738	De novo purine biosynthesis	P02901	Adenosuccinate lyase	HUMAN|HGNC=291|UniProtKB=P30566	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	DROME|FlyBase=FBgn0011286|UniProtKB=Q24498	Ryanodine receptor	ISS	15858232	PubMed	PTHR13715:SF79	RYANODINE RECEPTOR
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00018	EGF receptor signaling pathway	P00547	PP2A	TAKRU|Ensembl=ENSTRUG00000011169|UniProtKB=H2TU36	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00050	Plasminogen activating cascade	P01260	pro-MMP-3	MOUSE|MGI=MGI=97010|UniProtKB=P28862	Stromelysin-1	ISS	93013057	PubMed	PTHR10201:SF215	STROMELYSIN-1
P00048	PI3 kinase pathway	P01182	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	CANLF|Ensembl=ENSCAFG00000004767|UniProtKB=E2RAV2	Uncharacterized protein	ISS			PTHR11405:SF5	CAD PROTEIN
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BOVIN|Ensembl=ENSBTAG00000006189|UniProtKB=P63258	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05913	Enkephalin release	P05974	G-Protein (i)	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00009	Axon guidance mediated by netrin	P00366	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00046	Oxidative stress response	P01135	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	TAS	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MACMU|Ensembl=ENSMMUG00000004886|UniProtKB=F7AGT9	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04393	Ras Pathway	P04551	RalGDS	BOVIN|Ensembl=ENSBTAG00000016827|UniProtKB=Q0VCY4	Ral guanine nucleotide dissociation stimulator-like 2	ISS	8939933	PubMed	PTHR23113:SF213	RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 2
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00780	Microtubule	STRPU|EnsemblGenome=SPU_003894|UniProtKB=W4XKG7	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF155	TUBULIN BETA-2 CHAIN
P02727	Androgen/estrogene/progesterone biosynthesis	P02829	Cholesterol acyltransferase	MOUSE|MGI=MGI=1332226|UniProtKB=O88908	Sterol O-acyltransferase 2	NAS	21392392	gi	PTHR10408:SF10	STEROL O-ACYLTRANSFERASE 2
P04392	P53 pathway feedback loops 1	P04540	Cop-1	PANTR|Ensembl=ENSPTRG00000001711|UniProtKB=H2R8E1	Ring finger and WD repeat domain 2	ISS	15103385	PubMed	PTHR44080:SF1	E3 UBIQUITIN-PROTEIN LIGASE RFWD2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	IDA	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	IDA	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	HUMAN|HGNC=4597|UniProtKB=P41594	Metabotropic glutamate receptor 5	ISS	12488551	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	RAT|RGD=1310508|UniProtKB=D4AEP0	Adenylosuccinate synthetase isozyme 2	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P04393	Ras Pathway	P04556	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04393	Ras Pathway	P04567	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00049	Parkinson disease	P01239	Cul-1	DANRE|ZFIN=ZDB-GENE-040426-2887|UniProtKB=F1Q7M5	Uncharacterized protein	ISS	12628165	PubMed	PTHR11932:SF81	CULLIN-1
P00034	Integrin signalling pathway	P00924	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	12411479	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	TAS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01420	FAK	CAEBR|Gene=CBG10801|UniProtKB=A8XBU1	Protein CBR-KIN-32	ISS			PTHR24418:SF367	FOCAL ADHESION KINASE, ISOFORM D
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=105372|UniProtKB=P49660	Somatostatin receptor type 4	IDA	12181435	PubMed	PTHR24229:SF52	SOMATOSTATIN RECEPTOR TYPE 4
P02775	Salvage pyrimidine ribonucleotides	P03150	Uridine kinase	ARATH|TAIR=AT4G26510|UniProtKB=O65583	Uridine kinase-like protein 4	ISS			PTHR10285:SF97	URIDINE KINASE-LIKE PROTEIN 3-RELATED
P00057	Wnt signaling pathway	P01453	Ebi	CANLF|Ensembl=ENSCAFG00000015543|UniProtKB=E2R263	Uncharacterized protein	ISS	11389839	PubMed	PTHR22846:SF40	F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN TBL1XR1
P00014	Cholesterol biosynthesis	P00491	Hydroxymethyl glutaryl CoA reductase	MOUSE|MGI=MGI=96159|UniProtKB=Q01237	3-hydroxy-3-methylglutaryl-coenzyme A reductase	ISS	Q29512	SPACC	PTHR10572:SF2	3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P06211	BMP/activin signaling pathway-drosophila	P06251	BMP/activin orthologous ligand	DROME|FlyBase=FBgn0000490|UniProtKB=P07713	Protein decapentaplegic	RCA	9759503	PubMed	PTHR11848:SF234	PROTEIN DECAPENTAPLEGIC
P00005	Angiogenesis	P00200	Dsh	CANLF|Ensembl=ENSCAFG00000016066|UniProtKB=E2R7K2	Uncharacterized protein	ISS	11212302	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P00048	PI3 kinase pathway	P01188	Gbetagamma	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00049	Parkinson disease	P01211	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00126	Fe65	BOVIN|Ensembl=ENSBTAG00000015655|UniProtKB=Q17QV1	Amyloid beta (A4) protein-binding, family B, member 1 (Fe65)	ISS	11441186	PubMed	PTHR14058:SF5	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1
P02757	O-antigen biosynthesis	P03045	dTDP-glucose 4,6-dehydratase	CAEBR|Gene=CBG03656|UniProtKB=A8WVJ0	Protein CBG03656	ISS			PTHR43000:SF7	DTDP-D-GLUCOSE 4,6-DEHYDRATASE
P00022	General transcription by RNA polymerase I	P00657	TBP	PANTR|Ensembl=ENSPTRG00000018827|UniProtKB=H2RD22	Uncharacterized protein	ISS	11988536	PubMed	PTHR10126:SF20	TATA-BOX-BINDING PROTEIN
P00019	Endothelin signaling pathway	P00570	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00912	Arp2/3	HUMAN|HGNC=706|UniProtKB=O15145	Actin-related protein 2/3 complex subunit 3	IPI	12473693	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01215	Syntaxin	HUMAN|HGNC=11442|UniProtKB=O15400	Syntaxin-7	IPI	14570579	PubMed	PTHR19957:SF90	SYNTAXIN-7
P00060	Ubiquitin proteasome pathway	P01492	E1	YEAST|SGD=S000002798|UniProtKB=P52488	Ubiquitin-activating enzyme E1-like	ISS			PTHR10953:SF5	SUMO-ACTIVATING ENZYME SUBUNIT 2
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	PANTR|Ensembl=ENSPTRG00000001368|UniProtKB=H2Q045	Uncharacterized protein	ISS	608972	OMIM	PTHR22952:SF105	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 4
P00005	Angiogenesis	P00211	GSK3beta	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00010	B cell activation	P00379	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00018	EGF receptor signaling pathway	P00539	14-3-3	DANRE|ZFIN=ZDB-GENE-030131-6583|UniProtKB=Q5PRD0	14-3-3 protein beta/alpha-A	ISS	10407019	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CHICK|Gene=ACTG2|UniProtKB=P63270	Actin, gamma-enteric smooth muscle	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CAEBR|Gene=CBG05858|UniProtKB=A8X1H0	Protein CBR-EGL-19 (Fragment)	ISS	15737619	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00023	General transcription regulation	P00658	TBP-associated factors	MACMU|Ensembl=ENSMMUG00000013450|UniProtKB=F6YGY4	Uncharacterized protein	ISS			PTHR10221:SF12	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BOVIN|Ensembl=ENSBTAG00000003762|UniProtKB=A5PJS1	GNB5 protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	PANTR|Ensembl=ENSPTRG00000007084|UniProtKB=H2Q9G5	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00018	EGF receptor signaling pathway	P00552	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	TAKRU|Ensembl=ENSTRUG00000017773|UniProtKB=H2V8M1	Uncharacterized protein (Fragment)	IDA	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MONDO|Ensembl=ENSMODG00000013079|UniProtKB=F7FB74	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00006	Apoptosis signaling pathway	P00289	FAS	PANTR|Ensembl=ENSPTRG00000002730|UniProtKB=H2R2U8	Fas (TNF receptor superfamily, member 6)	ISS			PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P00019	Endothelin signaling pathway	P00567	PKG	DROME|FlyBase=FBgn0000721|UniProtKB=Q03043	cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B	ISS			PTHR24353:SF108	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01404	SPK	HUMAN|HGNC=11240|UniProtKB=Q9NYA1	Sphingosine kinase 1	IDA	12391145	PubMed	PTHR12358:SF47	SPHINGOSINE KINASE 1
P00029	Huntington disease	P00799	JNK-2	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00023	General transcription regulation	P00664	TFIIH complex	MACMU|Ensembl=ENSMMUG00000018605|UniProtKB=Q5TM73	General transcription factor IIH polypeptide 4	ISS			PTHR13152:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	XENTR|Xenbase=XB-GENE-941426|UniProtKB=Q28HZ4	Novel Rho protein	ISS	12024019	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PANTR|Ensembl=ENSPTRG00000006175|UniProtKB=H2R2N7	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF721	MYOSIN-6
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	BOVIN|Ensembl=ENSBTAG00000011723|UniProtKB=E1BKL6	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00018	EGF receptor signaling pathway	P00552	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00015	Circadian clock system	G01497	cry	ARATH|TAIR=AT4G08920|UniProtKB=Q43125	Cryptochrome-1	ISS			PTHR11455:SF18	DEOXYRIBODIPYRIMIDINE PHOTO-LYASE, MITOCHONDRIAL
P00034	Integrin signalling pathway	P00907	ERK	MONDO|Ensembl=ENSMODG00000004896|UniProtKB=F7C2C6	Uncharacterized protein (Fragment)	ISS	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00048	PI3 kinase pathway	P01185	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00011	Blood coagulation	P00458	GP IIIa	CANLF|Ensembl=ENSCAFG00000013735|UniProtKB=F1PPG5	Integrin beta	ISS	5805343	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00054	Toll receptor signaling pathway	P01342	IRAK4	MACMU|Ensembl=ENSMMUG00000000204|UniProtKB=F7HHC6	Interleukin-1 receptor-associated kinase 4 isoform a	ISS			PTHR24419:SF22	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MACMU|Ensembl=ENSMMUG00000001353|UniProtKB=F7D6T8	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00021	FGF signaling pathway	P00644	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IGI	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	15572354	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	TAKRU|Ensembl=ENSTRUG00000017773|UniProtKB=H2V8M1	Uncharacterized protein (Fragment)	IDA	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	TAS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	YEAST|SGD=S000002874|UniProtKB=Q03306	Serine/threonine-protein kinase PKH3	ISS			PTHR24356:SF238	SERINE/THREONINE-PROTEIN KINASE PKH3
P00029	Huntington disease	P00807	Actin	DAPPU|EnsemblGenome=DAPPUDRAFT_228751|UniProtKB=E9HGF5	Cytoplasmatic actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00029	Huntington disease	P00811	Arp2/3 complex	BOVIN|Ensembl=ENSBTAG00000046248|UniProtKB=Q58CQ2	Actin-related protein 2/3 complex subunit 1B	ISS	9618202	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04570	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	IC	11256888	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00009	Axon guidance mediated by netrin	P00363	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	ISS	14698601	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00012	Cadherin signaling pathway	P00474	Wnt	XENTR|Xenbase=XB-GENE-960148|UniProtKB=F6XMD3	Protein Wnt (Fragment)	ISS	8717036	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00010	B cell activation	P00398	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00034	Integrin signalling pathway	P00907	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00206	Wnt	PANTR|Ensembl=ENSPTRG00000004519|UniProtKB=H2Q569	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	RCA	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	MACMU|Ensembl=ENSMMUG00000005012|UniProtKB=F7AM42	Casein kinase I isoform alpha-like protein	ISS	11437445	PubMed	PTHR11909:SF139	CASEIN KINASE I ISOFORM ALPHA-LIKE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00313	IKK	PANTR|Ensembl=ENSPTRG00000020202|UniProtKB=H2QW34	Uncharacterized protein	ISS	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00019	Endothelin signaling pathway	P00583	cPLA2	DANRE|ZFIN=ZDB-GENE-990415-45|UniProtKB=P50392	Cytosolic phospholipase A2	IGI	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00057	Wnt signaling pathway	P01463	Kremen	PANTR|Ensembl=ENSPTRG00000014214|UniProtKB=H2R709	Uncharacterized protein	ISS			PTHR24269:SF13	KREMEN PROTEIN 1
P00057	Wnt signaling pathway	P01451	Galpha	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	IDA	8838318	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IDA	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00025	Hedgehog signaling pathway	P00691	CBP	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	TAS	10644715	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00057	Wnt signaling pathway	P01448	CBP	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	IDA	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04398	p53 pathway feedback loops 2	P04665	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04559	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_115566|UniProtKB=C3XYC8	Putative uncharacterized protein	IDA	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00047	PDGF signaling pathway	P01160	IP3 receptor	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00015	Circadian clock system	G01501	cry	BOVIN|Ensembl=ENSBTAG00000010149|UniProtKB=F1MXB2	Uncharacterized protein	ISS	14507900	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00053	T cell activation	P01336	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=1549775|UniProtKB=G3V987	Protein Pcdhb17	ISS	8120095	PubMed	PTHR24028:SF71	PROTOCADHERIN BETA-16
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00029	Huntington disease	P00774	Dynein complex	DROME|FlyBase=FBgn0013810|UniProtKB=Q9VJC6	Dynein heavy chain at 36C	IPI	9454836	PubMed	PTHR10676:SF354	DYNEIN HEAVY CHAIN AT 36C
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Ensembl=ENSBTAG00000014674|UniProtKB=P41985	Muscarinic acetylcholine receptor M2	ISS	8100450	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00053	T cell activation	P01296	TCR zeta	RAT|RGD=2305|UniProtKB=Q4V7G0	CD3 antigen, zeta polypeptide, isoform CRA_b	IGI	9012833	PubMed	PTHR10035:SF2	T-CELL SURFACE GLYCOPROTEIN CD3 ZETA CHAIN
P00053	T cell activation	P01331	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00053	T cell activation	P01300	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BRAFL|Gene=BRAFLDRAFT_118160|UniProtKB=C3Z2P0	Protein Wnt	TAS	8717036	PubMed	PTHR12027:SF77	PROTEIN WNT-5
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01161	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00048	PI3 kinase pathway	P01192	p110	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IDA	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00029	Huntington disease	P00793	Arfaptin-2	CANLF|Ensembl=ENSCAFG00000006457|UniProtKB=E2QV23	Uncharacterized protein	ISS	11854752	PubMed	PTHR12141:SF3	ARFAPTIN-2
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00048	PI3 kinase pathway	P01199	Galpha	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01012	PICK	RAT|RGD=69437|UniProtKB=Q9EP80	PRKCA-binding protein	ISS	12941441	PubMed	PTHR12141:SF1	PRKCA-BINDING PROTEIN
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	TAS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00541	Spry	BOVIN|Ensembl=ENSBTAG00000010245|UniProtKB=F1MIH6	Uncharacterized protein	ISS			PTHR12365:SF9	PROTEIN SPROUTY HOMOLOG 3
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	11832947	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00019	Endothelin signaling pathway	P00574	Big ET1-4	DANRE|ZFIN=ZDB-GENE-000920-1|UniProtKB=A5WW41	Uncharacterized protein	IGI	20393975	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P00001	Adrenaline and noradrenaline biosynthesis	P00067	MAO	PANTR|Ensembl=ENSPTRG00000021817|UniProtKB=H2QYH6	Amine oxidase [flavin-containing]	ISS	90344230	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P04398	p53 pathway feedback loops 2	P04651	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	3035212	PubMed	PTHR24070:SF385	GTPASE HRAS
P00019	Endothelin signaling pathway	P00589	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IGI	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04372	5-Hydroxytryptamine degredation	P04401	Monoamine Oxidase	HUMAN|HGNC=6833|UniProtKB=P21397	Amine oxidase [flavin-containing] A	ISS	90344230	PubMed	PTHR43563:SF3	AMINE OXIDASE  FLAVIN-CONTAINING  A
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	ARATH|TAIR=AT1G04600|UniProtKB=F4I5Q6	Myosin-7	IC			PTHR13140:SF256	MYOSIN-10-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	91072385	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00805	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00002	Alpha adrenergic receptor signaling pathway	P00078	Alpha1A/1B/1C	MOUSE|MGI=MGI=87935|UniProtKB=P30545	Alpha-2B adrenergic receptor	IC	6323229	PubMed	PTHR24248:SF26	ALPHA-2B ADRENERGIC RECEPTOR
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	TAS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	CHLTR|EnsemblGenome=CT_816|UniProtKB=O84823	Glutamine--fructose-6-phosphate aminotransferase [isomerizing]	ISS			PTHR10937:SF0	GH12731P-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=12784|UniProtKB=P41221	Protein Wnt-5a	TAS	11266476	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	MACMU|Ensembl=ENSMMUG00000010678|UniProtKB=F7AXI7	Uncharacterized protein	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00034	Integrin signalling pathway	P00948	Rho	CHICK|Ensembl=ENSGALG00000001569|UniProtKB=Q9PSX7	Rho-related GTP-binding protein RhoC	ISS	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00047	PDGF signaling pathway	P01153	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00038	JAK/STAT signaling pathway	P01027	STAT	MONDO|Ensembl=ENSMODG00000014836|UniProtKB=F7D2D3	Signal transducer and activator of transcription	ISS	96102059	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00004	Alzheimer disease-presenilin pathway	P00114	actin	RAT|RGD=2027|UniProtKB=P63269	Actin, gamma-enteric smooth muscle	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	EMENI|EnsemblGenome=CADANIAG00006296|UniProtKB=Q5ASG1	Putative synaptobrevin homologue SNC1/2 (Eurofung)	ISS			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P02726	Aminobutyrate degradation	P02825	4-aminobutyrate aminotransferase	ECOLI|EcoGene=EG10361|UniProtKB=P22256	4-aminobutyrate aminotransferase GabT	ISS			PTHR43206:SF2	4-AMINOBUTYRATE AMINOTRANSFERASE GABT
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	BOVIN|Ensembl=ENSBTAG00000006969|UniProtKB=Q2KJD0	Tubulin beta-5 chain	ISS	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00010	B cell activation	P00402	Jnk	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	CHICK|Gene=PSEN2|UniProtKB=Q90X07	Presenilin-2	TAS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00036	Interleukin signaling pathway	P00974	Receptor subunit beta	PANTR|Ensembl=ENSPTRG00000000840|UniProtKB=H2PZ74	Uncharacterized protein	ISS	8943050	PubMed	PTHR23036:SF79	INTERLEUKIN-12 RECEPTOR SUBUNIT BETA-2
P00029	Huntington disease	P00790	beta-Tubulin	MACMU|Ensembl=ENSMMUG00000023684|UniProtKB=P69895	Tubulin beta chain	ISS	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02788	Xanthine and guanine salvage pathway	P03250	Guanosine phosphorylase	MOUSE|MGI=MGI=97365|UniProtKB=P23492	Purine nucleoside phosphorylase	ISS	7903568	PubMed	PTHR11904:SF12	PURINE NUCLEOSIDE PHOSPHORYLASE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00005	Angiogenesis	P00253	Axin	PANTR|Ensembl=ENSPTRG00000007537|UniProtKB=H2R1H5	Uncharacterized protein	ISS	9554852	PubMed	PTHR10845:SF11	AXIN-1
P00019	Endothelin signaling pathway	P00591	PLCbeta	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04393	Ras Pathway	P04572	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04550	Ral	MOUSE|MGI=MGI=1927243|UniProtKB=P63321	Ras-related protein Ral-A	ISS	11025226	PubMed	PTHR24070:SF174	RAS-RELATED PROTEIN RAL-A
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	176910	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00629	PP2A	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	BRAFL|Gene=BRAFLDRAFT_124235|UniProtKB=C3Y3Q1	Putative uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF89	TUBULIN BETA-4 CHAIN
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	CANLF|Ensembl=ENSCAFG00000008293|UniProtKB=E2R9M9	Uncharacterized protein	ISS	12549854	PubMed	PTHR11309:SF22	FRIZZLED-3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04495	TSC1	MACMU|Ensembl=ENSMMUG00000009918|UniProtKB=F6Y6G0	Hamartin isoform 1	ISS	12167664	PubMed	PTHR15154:SF2	HAMARTIN
P00005	Angiogenesis	P00243	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00590	IP3 R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04393	Ras Pathway	P04552	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04572	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MONDO|Ensembl=ENSMODG00000013970|UniProtKB=F6R6X5	Uncharacterized protein	ISS			PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P04397	p53 pathway by glucose deprivation	P04640	p53	MACMU|Ensembl=ENSMMUG00000008639|UniProtKB=P56424	Cellular tumor antigen p53	TAS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	G06677	Junc	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	RCA	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00011	Blood coagulation	P00419	FXIIIa	MACMU|Ensembl=ENSMMUG00000000244|UniProtKB=F6XAB8	Uncharacterized protein	ISS	9961357	gi	PTHR19325:SF314	COAGULATION FACTOR XIII B CHAIN
P00053	T cell activation	P01309	fos	BOVIN|Ensembl=ENSBTAG00000004322|UniProtKB=O77628	Proto-oncogene c-Fos	TAS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2344|UniProtKB=P08485	Muscarinic acetylcholine receptor M4	IDA	11166329	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P04393	Ras Pathway	P04547	Ras	DAPPU|EnsemblGenome=DAPPUDRAFT_301818|UniProtKB=E9I1I7	Putative uncharacterized protein	ISS	20148920	PubMed	PTHR24070:SF385	GTPASE HRAS
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01444	Wnt	MONDO|Ensembl=ENSMODG00000015364|UniProtKB=F6WHM2	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00049	Parkinson disease	P01213	Cyclin E	CHICK|Gene=CCNE1|UniProtKB=P49707	G1/S-specific cyclin-E1	IDA	1705768	gi	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00006	Apoptosis signaling pathway	P00299	Caspase 8	MACMU|Ensembl=ENSMMUG00000031296|UniProtKB=F7C587	Uncharacterized protein	ISS	8681376	PubMed	PTHR10454:SF162	CASPASE-8
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	CHICK|Ensembl=ENSGALG00000000889|UniProtKB=R9PXL1	Uncharacterized protein	IDA	10617630	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00034	Integrin signalling pathway	P00920	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IPI	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00052	TGF-beta signaling pathway	P01284	JNK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	TAS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00010	B cell activation	P00384	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IDA	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	IDA	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00053	T cell activation	P01294	NFAT	HUMAN|HGNC=7778|UniProtKB=Q14934	Nuclear factor of activated T-cells, cytoplasmic 4	IGI	9133421	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DROME|FlyBase=FBgn0004623|UniProtKB=P29829	Guanine nucleotide-binding protein subunit beta-2	IC			PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	9395335	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04397	p53 pathway by glucose deprivation	P04641	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01414	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00049	Parkinson disease	P01230	Src kinase	MOUSE|MGI=MGI=88169|UniProtKB=P16277	Tyrosine-protein kinase Blk	IDA	9013950	PubMed	PTHR24418:SF181	TYROSINE-PROTEIN KINASE BLK
P02743	Formyltetrahydroformate biosynthesis	P02953	Cobalamin dependent homocysteine transmethylase	CAEEL|WormBase=WBGene00010988|UniProtKB=Q09582	Probable methionine synthase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	RAT|RGD=620023|UniProtKB=P10980	Muscarinic acetylcholine receptor M2	ISS	8100450	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P02740	De novo pyrimidine ribonucleotides biosythesis	P02922	Orotate phosphoribosyltransferase	FUSNN|EnsemblGenome=FN0427|UniProtKB=P58856	Orotate phosphoribosyltransferase	ISS			PTHR19278:SF9	URIDINE 5'-MONOPHOSPHATE SYNTHASE
P00006	Apoptosis signaling pathway	P00269	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=263|UniProtKB=P29274	Adenosine receptor A2a	IDA			PTHR24246:SF27	ADENOSINE RECEPTOR A2A
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DICDI|dictyBase=DDB_G0268744|UniProtKB=Q55EU6	Putative actin-23	IDA	14684598	PubMed	PTHR11937:SF154	ACTIN-17-RELATED
P00019	Endothelin signaling pathway	P00591	PLCbeta	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00018	EGF receptor signaling pathway	P00551	Akt	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	IGI	98382502	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	ANOGA|EnsemblGenome=AGAP011481|UniProtKB=Q7PMY1	AGAP011481-PA (Fragment)	ISS	12441358	PubMed	PTHR24247:SF117	5-HYDROXYTRYPTAMINE RECEPTOR 2A-RELATED
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	HUMAN|HGNC=4581|UniProtKB=Q13003	Glutamate receptor ionotropic, kainate 3	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IDA	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04372	5-Hydroxytryptamine degredation	P04401	Monoamine Oxidase	CANLF|Gene=MAOB|UniProtKB=Q7YRB7	Amine oxidase [flavin-containing] B	ISS	90344230	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P04398	p53 pathway feedback loops 2	P04657	P110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS			PTHR24072:SF248	SUBFAMILY NOT NAMED
P05916	Opioid prodynorphin pathway	P05998	Kappa Receptor	BOVIN|Ensembl=ENSBTAG00000000914|UniProtKB=Q2KIP6	Kappa-type opioid receptor	ISS	11259487	PubMed	PTHR24229:SF1	KAPPA-TYPE OPIOID RECEPTOR
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	TAS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00552	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	IC	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00012	Cadherin signaling pathway	P00475	Frizzled	DANRE|ZFIN=ZDB-GENE-000906-4|UniProtKB=B0S5E7	Frizzled homolog 9	IDA	11212302	PubMed	PTHR11309:SF79	FRIZZLED-9
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	SCHPO|PomBase=SPAC17G8.04c|UniProtKB=Q10316	Actin-related protein 2/3 complex subunit 5	ISS			PTHR12644:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00057	Wnt signaling pathway	P01465	Ggamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00034	Integrin signalling pathway	P00951	Jnk	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000008826|UniProtKB=F6XUU0	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00587	Raf-1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04541	p90RSK	PANTR|Ensembl=ENSPTRG00000000387|UniProtKB=H2PYE3	Ribosomal protein S6 kinase	ISS	12769834	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00020	FAS signaling pathway	P00616	Nuclear Lamin	DANRE|ZFIN=ZDB-GENE-990630-13|UniProtKB=B3DFN3	Lamin B2	TAS	11165516	PubMed	PTHR23239:SF152	LAMIN-B2
P00034	Integrin signalling pathway	P00922	Collagen	CANLF|Ensembl=ENSCAFG00000004656|UniProtKB=F1PVR1	Uncharacterized protein	ISS			PTHR23220:SF5	INTEGRIN ALPHA-8
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	HUMAN|HGNC=9857|UniProtKB=P61224	Ras-related protein Rap-1b	IDA	10476970	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01238	14-3-3	MACMU|Ensembl=ENSMMUG00000013855|UniProtKB=F6RM85	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF14	14-3-3 PROTEIN SIGMA
P00010	B cell activation	P00368	vav	MOUSE|MGI=MGI=98923|UniProtKB=P27870	Proto-oncogene vav	IGI	14623913	PubMed	PTHR22826:SF112	PROTO-ONCOGENE VAV
P00029	Huntington disease	P00799	JNK-2	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00034	Integrin signalling pathway	P00940	Src	HUMAN|HGNC=11283|UniProtKB=P12931	Proto-oncogene tyrosine-protein kinase Src	IPI	11078745	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00048	PI3 kinase pathway	P01181	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00021	FGF signaling pathway	P00644	p38	DROME|FlyBase=FBgn0015765|UniProtKB=O62618	Mitogen-activated protein kinase 14A	IGI	10851062	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	RAT|RGD=3275|UniProtKB=Q62849	Proprotein convertase subtilisin/kexin type 7	IDA			PTHR42884:SF12	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 7
P00054	Toll receptor signaling pathway	P01375	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	HUMAN|HGNC=4421|UniProtKB=P30968	Gonadotropin-releasing hormone receptor	ISS	12629106	PubMed	PTHR24241:SF22	GONADOTROPIN-RELEASING HORMONE RECEPTOR
P00059	p53 pathway	G01579	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04393	Ras Pathway	P04565	MKK4/7	MONDO|Ensembl=ENSMODG00000008266|UniProtKB=F6Z879	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	HUMAN|HGNC=1957|UniProtKB=P32297	Neuronal acetylcholine receptor subunit alpha-3	IC	18005395	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P00048	PI3 kinase pathway	G01545	scl-1	CAEEL|WormBase=WBGene00009890|UniProtKB=Q93747	SCP-Like extracellular protein	ISS			PTHR10334:SF217	SCP-LIKE EXTRACELLULAR PROTEIN
P00018	EGF receptor signaling pathway	P00549	EGF	RAT|RGD=621341|UniProtKB=P43322	Pro-neuregulin-1, membrane-bound isoform	RCA			PTHR11100:SF7	PRO-NEUREGULIN-1, MEMBRANE-BOUND ISOFORM
P00005	Angiogenesis	P00209	FAK	RAT|RGD=3443|UniProtKB=O35346	Focal adhesion kinase 1	ISS	9182576	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00006	Apoptosis signaling pathway	P00260	AKT	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	ISS	9716402	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01440	Cadherin	BOVIN|Ensembl=ENSBTAG00000011349|UniProtKB=E1BQ10	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF272	CADHERIN-24
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	8838318	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=2136741|UniProtKB=Q8CDY9	Protein Pcdhb7	IDA	8120095	PubMed	PTHR24028:SF148	PROTEIN PCDHB7
P00018	EGF receptor signaling pathway	G01511	SPRY	CANLF|Ensembl=ENSCAFG00000006250|UniProtKB=F1Q4C2	Uncharacterized protein	ISS	12027893	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P00059	p53 pathway	G04689	Cyclin G	PANTR|Ensembl=ENSPTRG00000017501|UniProtKB=H2QRY5	Cyclin G1	ISS			PTHR10177:SF59	CYCLIN-G1
P00056	VEGF signaling pathway	P01417	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	IGI	6466184	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00018	EGF receptor signaling pathway	P00547	PP2A	CHICK|Ensembl=ENSGALG00000010273|UniProtKB=P48463	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	NAS	1662645	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P02754	Methylcitrate cycle	P03028	Aconitase	CHICK|Gene=ACO1|UniProtKB=Q90875	Cytoplasmic aconitate hydratase	ISS			PTHR11670:SF32	CYTOPLASMIC ACONITATE HYDRATASE
P00052	TGF-beta signaling pathway	P01288	FKBP12	RAT|RGD=1560660|UniProtKB=D3ZZR9	Peptidyl-prolyl cis-trans isomerase	ISS			PTHR10516:SF333	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP2
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	BOVIN|Ensembl=ENSBTAG00000014600|UniProtKB=E1BQ12	Uncharacterized protein	ISS	12890691	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ORNAN|Ensembl=ENSOANG00000000460|UniProtKB=F7F4W9	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00021	FGF signaling pathway	P00627	ERK1-2	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	IGI	20032362	PubMed	PTHR24055:SF330	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00938	Cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00053	T cell activation	P01336	Jnk	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	LEIMA|EnsemblGenome=LmjF.18.1080|UniProtKB=Q27687	Protein kinase A catalytic subunit	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	RAT|RGD=69319|UniProtKB=P54313	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CHICK|Ensembl=ENSGALG00000015336|UniProtKB=Q03481	Alpha8 subunit of nicotinic acetylcholine receptor	IC	85270494	PubMed	PTHR18945:SF761	ALPHA8 SUBUNIT OF NICOTINIC ACETYLCHOLINE RECEPTOR
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	PANTR|Ensembl=ENSPTRG00000015241|UniProtKB=Q5IS72	D(3) dopamine receptor	ISS	7651368	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00047	PDGF signaling pathway	P01151	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P01486	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00590	IP3 R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00010	B cell activation	P00402	Jnk	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P06587	Nicotine pharmacodynamics pathway	P06605	KCNK3/9	MACMU|Ensembl=ENSMMUG00000005826|UniProtKB=F6VE51	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Ensembl=ENSPTRG00000022245|UniProtKB=H2QZ29	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00004	Alzheimer disease-presenilin pathway	P00174	CD44 N-terminal fragment	CHICK|Ensembl=ENSGALG00000007849|UniProtKB=F1NL98	Uncharacterized protein	IDA	14871815	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00054	Toll receptor signaling pathway	P01375	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	PLAF7|EnsemblGenome=PFB0200c|UniProtKB=O96142	Aspartate aminotransferase	ISS			PTHR11879:SF10	ASPARTATE AMINOTRANSFERASE
P00021	FGF signaling pathway	P00638	PLCgamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CAEEL|WormBase=WBGene00004036|UniProtKB=G5EFI8	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	CAEBR|Gene=CBG11160|UniProtKB=A8XCL2	Protein CBR-SNT-1	ISS			PTHR10024:SF227	SYNAPTOTAGMIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00729	Goalpha	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	IDA	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05949	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	10521483	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IDA	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00013	Cell cycle	P00480	Proteasome	MOUSE|MGI=MGI=1201670|UniProtKB=O35226	26S proteasome non-ATPase regulatory subunit 4	ISS	13645506	gi	PTHR10223:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4
P04393	Ras Pathway	P04557	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00005	Angiogenesis	P00188	Ets	ORNAN|Ensembl=ENSOANG00000012104|UniProtKB=F7FH70	Uncharacterized protein	ISS	3284179	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05915	Opioid proenkephalin pathway	P05994	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00047	PDGF signaling pathway	P01162	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05913	Enkephalin release	P05976	Enkephalin	MACMU|Ensembl=ENSMMUG00000006775|UniProtKB=F7H3N8	Uncharacterized protein	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00021	FGF signaling pathway	P00634	MEKK1-5	HUMAN|HGNC=6855|UniProtKB=Q99759	Mitogen-activated protein kinase kinase kinase 3	IGI	11730323	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00010	B cell activation	P00402	Jnk	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IDA	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02788	Xanthine and guanine salvage pathway	P03250	Guanosine phosphorylase	MYCTU|EnsemblGenome=Rv3307|UniProtKB=P9WP01	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00048	PI3 kinase pathway	P01176	JAK	MACMU|Ensembl=ENSMMUG00000014558|UniProtKB=F7GT47	Tyrosine-protein kinase	ISS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	IDA	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00037	Ionotropic glutamate receptor pathway	P01015	Glu4	HUMAN|HGNC=4574|UniProtKB=P48058	Glutamate receptor 4	ISS	12497607	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00036	Interleukin signaling pathway	P00997	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	7680960	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IC	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00018	EGF receptor signaling pathway	P00562	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00059	p53 pathway	G04702	p53	MOUSE|MGI=MGI=98834|UniProtKB=P02340	Cellular tumor antigen p53	TAS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00036	Interleukin signaling pathway	P00996	STAT	BOVIN|Gene=STAT5B|UniProtKB=Q9TUM3	Signal transducer and activator of transcription 5B	IC	20119183	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00019	Endothelin signaling pathway	P00585	ECE1-3	BOVIN|Ensembl=ENSBTAG00000021050|UniProtKB=E1BJE2	Uncharacterized protein	ISS	9931490	PubMed	PTHR11733:SF195	ENDOTHELIN-CONVERTING ENZYME-LIKE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=11334|UniProtKB=P35346	Somatostatin receptor type 5	IDA	12181435	PubMed	PTHR24229:SF20	SOMATOSTATIN RECEPTOR TYPE 5
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00034	Integrin signalling pathway	P00916	Ras	DICDI|dictyBase=DDB_G0293434|UniProtKB=P15064	Ras-like protein rasG	IPI	7997267	PubMed	PTHR24070:SF282	RAS GTPASE-RELATED
P00057	Wnt signaling pathway	P01457	GBeta	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2342|UniProtKB=P08482	Muscarinic acetylcholine receptor M1	IDA			PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00021	FGF signaling pathway	P00623	FGF	PANTR|Ensembl=ENSPTRG00000020014|UniProtKB=H2QVS4	Fibroblast growth factor	ISS	11306498	PubMed	PTHR11486:SF72	FIBROBLAST GROWTH FACTOR 20
P00045	Notch signaling pathway	P01117	Neuralized	RAT|RGD=1306409|UniProtKB=B0BMZ0	Neuralized-like 2 (Drosophila)	RCA			PTHR12429:SF8	NEURALIZED-LIKE PROTEIN 2
P00029	Huntington disease	P00777	CBP	ARATH|TAIR=AT1G16710|UniProtKB=Q9FWQ5	Histone acetyltransferase HAC12	IDA	10823891	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P05913	Enkephalin release	P05974	G-Protein (i)	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00059	p53 pathway	G04694	p110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05918	p38 MAPK pathway	P06027	CREB	CHICK|Ensembl=ENSGALG00000008494|UniProtKB=Q7SX83	CAMP response element-binding protein	ISS	11752053	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00053	T cell activation	P01324	rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	IDA	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	HALSA|EnsemblGenome=VNG_0606G|UniProtKB=Q9HRP3	Cysteine synthase	ISS			PTHR10314:SF159	CYSTEINE SYNTHASE A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04580	TRH Receptor	CAEBR|Gene=CBG03939|UniProtKB=A8WVT3	Protein CBR-NMUR-4	ISS			PTHR24243:SF197	NMUR  NEUROMEDIN U RECEPTOR  HOMOLOG
P00059	p53 pathway	P04633	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00907	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	IDA	93028473	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01179	PKB	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	TAS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00049	Parkinson disease	P01236	Casein kinase II	DICDI|dictyBase=DDB_G0276885|UniProtKB=Q02720	Casein kinase II subunit alpha	IDA	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00021	FGF signaling pathway	P00648	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00625	MKK3,6	MOUSE|MGI=MGI=1346868|UniProtKB=O09110	Dual specificity mitogen-activated protein kinase kinase 3	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000011757|UniProtKB=Q9XT97	Presenilin-1	IDA	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P02771	Pyrimidine Metabolism	P03128	Dihydrouracil Dehydrogenase	HUMAN|HGNC=3012|UniProtKB=Q12882	Dihydropyrimidine dehydrogenase [NADP(+)]	IDA	8912928	PubMed	PTHR43073:SF2	DIHYDROPYRIMIDINE DEHYDROGENASE  NADP +
P00005	Angiogenesis	P00215	Nck	MOUSE|MGI=MGI=109601|UniProtKB=Q99M51	Cytoplasmic protein NCK1	ISS	12874226	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	ORYSJ|EnsemblGenome=OS03G0712800|UniProtKB=Q4W8D0	Glutamine synthetase cytosolic isozyme 1-3	ISS			PTHR20852:SF58	GLUTAMINE SYNTHETASE CYTOSOLIC ISOZYME 1-2
P00005	Angiogenesis	P00211	GSK3beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	DICDI|dictyBase=DDB_G0292998|UniProtKB=P32252	Ras-like protein rasB	ISS	7997267	PubMed	PTHR24070:SF206	RAS-LIKE PROTEIN RASB
P00057	Wnt signaling pathway	P01472	Histone deacetylase	BOVIN|Ensembl=ENSBTAG00000011849|UniProtKB=F1MFZ7	Histone deacetylase	ISS	10485845	PubMed	PTHR10625:SF171	HISTONE DEACETYLASE 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00025	Hedgehog signaling pathway	P00692	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	CANLF|Ensembl=ENSCAFG00000015081|UniProtKB=E2RMT4	Uncharacterized protein	ISS	9618202	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00005	Angiogenesis	P00221	JNK1	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	ARATH|TAIR=AT1G57870|UniProtKB=Q9FVS6	Shaggy-related protein kinase delta	IDA			PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	CAEEL|WormBase=WBGene00004860|UniProtKB=Q09488	Serine/threonine-protein kinase sma-6	TAS	9395284	PubMed	PTHR23255:SF68	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00010	B cell activation	P00371	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00243	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	HUMAN|HGNC=4222|UniProtKB=Q7Z4P5	Growth/differentiation factor 7	TAS	9759503	PubMed	PTHR11848:SF160	GROWTH/DIFFERENTIATION FACTOR 7
P00045	Notch signaling pathway	P01113	Pen-2	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	PANTR|Ensembl=ENSPTRG00000014418|UniProtKB=H2QLS0	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00056	VEGF signaling pathway	P01417	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01165	SRF	MOUSE|MGI=MGI=106658|UniProtKB=Q9JM73	Serum response factor	ISS	8660892	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00053	T cell activation	P01305	Calmodulin	TETTS|EnsemblGenome=TTHERM_00630500|UniProtKB=Q241P0	Calmodulin 1	ISS			PTHR23050:SF245	AT16150P-RELATED
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00021	FGF signaling pathway	P00628	JNK1-3	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00059	p53 pathway	P01486	Akt	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	TAS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	XENTR|Xenbase=XB-GENE-494200|UniProtKB=F7CS79	Uncharacterized protein	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00029	Huntington disease	P00807	Actin	CHICK|Ensembl=ENSGALG00000009844|UniProtKB=P68034	Actin, alpha cardiac muscle 1	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00013	Cell cycle	P00480	Proteasome	PANTR|Ensembl=ENSPTRG00000022722|UniProtKB=H2R079	Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 12	ISS	9426256	PubMed	PTHR10855:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12
P00036	Interleukin signaling pathway	P00990	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04396	Vitamin D metabolism and pathway	P04604	FdxR	DEIRA|EnsemblGenome=DR_0496|UniProtKB=Q9RX19	Ferredoxin/ferredoxin--NADP reductase, putative	ISS			PTHR11938:SF114	SUBFAMILY NOT NAMED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	RAT|RGD=621440|UniProtKB=Q63511	G protein-activated inward rectifier potassium channel 3	ISS	2433589	PubMed	PTHR11767:SF17	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 3
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P05915	Opioid proenkephalin pathway	P05994	G-protein	MACMU|Ensembl=ENSMMUG00000017374|UniProtKB=F7H6T7	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	MOUSE|MGI=MGI=106684|UniProtKB=Q8R090	Chromaffin granule amine transporter	ISS	12135927	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00049	Parkinson disease	P01222	Ubc6	HUMAN|HGNC=19268|UniProtKB=Q8N2K1	Ubiquitin-conjugating enzyme E2 J2	ISS	12859888	PubMed	PTHR43972:SF1	UBIQUITIN-CONJUGATING ENZYME E2 J2
P00036	Interleukin signaling pathway	P00990	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MOUSE|MGI=MGI=95774|UniProtKB=Q8CGK7	Guanine nucleotide-binding protein G(olf) subunit alpha	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000012820|UniProtKB=F1MDL3	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00045	Notch signaling pathway	P01101	Su(H)	CANLF|Ensembl=ENSCAFG00000016387|UniProtKB=E2QV83	Uncharacterized protein	ISS	15187023	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00010	B cell activation	P00383	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DICDI|dictyBase=DDB_G0275023|UniProtKB=Q553U6	Putative actin-22	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	DROME|FlyBase=FBgn0031441|UniProtKB=Q9VQE3	CG9962	ISS	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02751	Lysine biosynthesis	P03013	Aspartate semialdehyde dehydrogenase	STRCO|Gene=CAB45481|UniProtKB=Q9XAI8	Aspartate-semialdehyde dehydrogenase	ISS			PTHR10174:SF2	ASPARTATE-SEMIALDEHYDE DEHYDROGENASE
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P04393	Ras Pathway	P04574	PLD	RAT|RGD=3350|UniProtKB=P70498	Phospholipase D2	IDA	12615079	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00010	B cell activation	P00379	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=88397|UniProtKB=Q9ERZ4	Muscarinic acetylcholine receptor M2	IDA	12181435	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	RAT|RGD=2746|UniProtKB=P31424	Metabotropic glutamate receptor 5	IDA	8314195	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00046	Oxidative stress response	P01129	JNK1/2	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00018	EGF receptor signaling pathway	P00554	Shc	DROME|FlyBase=FBgn0015296|UniProtKB=Q9V3C8	DShc protein	ISS	8491186	PubMed	PTHR10337:SF11	DSHC PROTEIN
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	2842690	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00005	Angiogenesis	P00256	PLC-gamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	HUMAN|HGNC=8568|UniProtKB=P09958	Furin	IDA	95328031	PubMed	PTHR42884:SF1	FURIN
P00002	Alpha adrenergic receptor signaling pathway	P00078	Alpha1A/1B/1C	MACMU|Ensembl=ENSMMUG00000023112|UniProtKB=B0S4P2	Alpha-1a adrenoceptor transcript variant 1	ISS	6323229	PubMed	PTHR24248:SF16	ALPHA-1A ADRENERGIC RECEPTOR
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MONDO|Ensembl=ENSMODG00000020204|UniProtKB=F6SED9	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00029	Huntington disease	P00774	Dynein complex	MONDO|Ensembl=ENSMODG00000006873|UniProtKB=F6PWI8	Uncharacterized protein	ISS	9454836	PubMed	PTHR12688:SF1	CYTOPLASMIC DYNEIN 1 LIGHT INTERMEDIATE CHAIN 2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000015240|UniProtKB=F6VUY3	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00047	PDGF signaling pathway	P01147	Nck	HUMAN|HGNC=7664|UniProtKB=P16333	Cytoplasmic protein NCK1	ISS	12874226	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00010	B cell activation	P00401	jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	RAT|RGD=3693|UniProtKB=Q01818	Chromaffin granule amine transporter	ISS	12135927	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00012	Cadherin signaling pathway	P00464	Fyn	BOVIN|Ensembl=ENSBTAG00000011851|UniProtKB=A0JNB0	Tyrosine-protein kinase Fyn	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00029	Huntington disease	P00797	p53	PANTR|Ensembl=ENSPTRG00000017465|UniProtKB=H2R3H1	Uncharacterized protein	ISS			PTHR12195:SF1	CYTOPLASMIC FMR1-INTERACTING PROTEIN 2
P00060	Ubiquitin proteasome pathway	P01491	E2	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g137658|UniProtKB=A7S6Q0	Predicted protein	ISS			PTHR43902:SF2	UBIQUITIN-CONJUGATING ENZYME E2 N
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00053	T cell activation	P01332	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00203	Erk	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01309	fos	BOVIN|Ensembl=ENSBTAG00000004322|UniProtKB=O77628	Proto-oncogene c-Fos	TAS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00018	EGF receptor signaling pathway	P00546	GAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	14707121	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00018	EGF receptor signaling pathway	P00552	Ras	EMENI|EnsemblGenome=CADANIAG00002552|UniProtKB=Q12526	Ras-like protein	ISS	7997267	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	LEIMA|EnsemblGenome=LmjF.09.0910|UniProtKB=Q4QHT2	Putative calmodulin	ISS	3885394	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00048	PI3 kinase pathway	P01188	Gbetagamma	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00036	Interleukin signaling pathway	P00968	Ikk	HUMAN|HGNC=1974|UniProtKB=O15111	Inhibitor of nuclear factor kappa-B kinase subunit alpha	IDA	14499113	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P02746	Heme biosynthesis	P02975	Uroporphyrinogen decarboxylase	CHLTR|EnsemblGenome=CT_747|UniProtKB=O84752	Uroporphyrinogen decarboxylase	ISS			PTHR21091:SF2	UROPORPHYRINOGEN DECARBOXYLASE
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	HUMAN|HGNC=4047|UniProtKB=O00144	Frizzled-9	TAS	8717036	PubMed	PTHR11309:SF79	FRIZZLED-9
P00021	FGF signaling pathway	P00641	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DANRE|ZFIN=ZDB-GENE-040426-2427|UniProtKB=F1Q6C0	Uncharacterized protein (Fragment)	ISS	3037538	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00922	Collagen	HUMAN|HGNC=2188|UniProtKB=Q99715	Collagen alpha-1(XII) chain	IDA	10778855	PubMed	PTHR45047:SF2	COLLAGEN ALPHA-1 XII  CHAIN
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00012	Cadherin signaling pathway	P00462	Casein kinase II	MACMU|Ensembl=ENSMMUG00000031224|UniProtKB=F7CKT2	Uncharacterized protein	ISS	10806215	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00056	VEGF signaling pathway	P01414	PLC-gamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00011	Blood coagulation	P00438	Bradykinin	MOUSE|MGI=MGI=1097705|UniProtKB=O08677	Kininogen-1	ISS	12643495	gi	PTHR13814:SF12	KININOGEN-1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	HUMAN|HGNC=8528|UniProtKB=P01178	Oxytocin-neurophysin 1	ISS	192340	OMIM	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04393	Ras Pathway	P04552	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IDA	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	RCA			PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05915	Opioid proenkephalin pathway	P05994	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04393	Ras Pathway	P04558	p38	DANRE|ZFIN=ZDB-GENE-990415-257|UniProtKB=O42376	Mitogen-activated protein kinase 12	ISS	10514528	PubMed	PTHR24055:SF339	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000013287|UniProtKB=E2RIY9	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF25	MITOGEN-ACTIVATED PROTEIN KINASE 4
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00807	Actin	DICDI|dictyBase=DDB_G0269234|UniProtKB=P07830	Major actin	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000002658|UniProtKB=F7CB14	Uncharacterized protein	ISS	12181435	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P02733	Carnitine metabolism	P02866	Carnitine dehydratase	HUMAN|HGNC=16001|UniProtKB=Q9HAC7	Succinate--hydroxymethylglutarate CoA-transferase	ISS			PTHR43949:SF6	SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE
P00049	Parkinson disease	P01227	20S proteasome	PANTR|Ensembl=ENSPTRG00000006264|UniProtKB=G2HIX7	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF11	PROTEASOME SUBUNIT ALPHA TYPE-6
P00020	FAS signaling pathway	P00593	Caspase9	MACMU|Ensembl=ENSMMUG00000018163|UniProtKB=F7FNC1	Caspase	ISS	8663294	PubMed	PTHR10454:SF157	CASPASE-9
P00021	FGF signaling pathway	P00636	FGFR1-4	MACMU|Ensembl=ENSMMUG00000009594|UniProtKB=F7A5X3	Receptor protein-tyrosine kinase	ISS			PTHR24416:SF130	FIBROBLAST GROWTH FACTOR RECEPTOR 2
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00047	PDGF signaling pathway	P01174	Rho	MACMU|Ensembl=ENSMMUG00000003896|UniProtKB=F7H5F6	Uncharacterized protein	ISS			PTHR12635:SF6	RHO GTPASE-ACTIVATING PROTEIN 6
P00050	Plasminogen activating cascade	P01245	PAI-1	MACMU|Ensembl=ENSMMUG00000009926|UniProtKB=F6Y5D7	Uncharacterized protein	ISS	189578	gi	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P02738	De novo purine biosynthesis	P02892	5-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase	LEIMA|EnsemblGenome=LmjF.04.0460|UniProtKB=Q9U0T7	Adenylosuccinate lyase	ISS			PTHR43411:SF1	ADENYLOSUCCINATE LYASE
P00029	Huntington disease	P00805	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00018	EGF receptor signaling pathway	P00552	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04561	SRF	PANTR|Ensembl=ENSPTRG00000018189|UniProtKB=H2QT21	Uncharacterized protein	ISS	15326221	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	BOVIN|Ensembl=ENSBTAG00000018989|UniProtKB=A5D7D8	GRM3 protein	ISS	12351712	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00005	Angiogenesis	P00184	Src	XENTR|Xenbase=XB-GENE-489820|UniProtKB=F7DXH6	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	EMENI|EnsemblGenome=CADANIAG00006296|UniProtKB=Q5ASG1	Putative synaptobrevin homologue SNC1/2 (Eurofung)	ISS			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	BOVIN|Ensembl=ENSBTAG00000020485|UniProtKB=P17870	Beta-arrestin-1	ISS	11742073	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IGI	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00057	Wnt signaling pathway	P01428	Frizzled	DANRE|ZFIN=ZDB-GENE-990415-223|UniProtKB=Q6NV44	Frizzled homolog 7a	IDA	8717036	PubMed	PTHR11309:SF31	FRIZZLED-7
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00006	Apoptosis signaling pathway	P00320	SODD	PANTR|Ensembl=ENSPTRG00000020170|UniProtKB=H2QW14	BCL2-associated athanogene 4	ISS	9915703	PubMed	PTHR12329:SF10	BAG FAMILY MOLECULAR CHAPERONE REGULATOR 4
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00010	B cell activation	P00391	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	TAKRU|Ensembl=ENSTRUG00000007253|UniProtKB=H2SZQ1	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	XENTR|Xenbase=XB-GENE-6067221|UniProtKB=F6Z0J4	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00018	EGF receptor signaling pathway	P00552	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	91232861	PubMed	PTHR24070:SF385	GTPASE HRAS
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	MACMU|Ensembl=ENSMMUG00000023317|UniProtKB=F6Y514	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000008205|UniProtKB=H2QBA3	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF1	CADHERIN-16
P00049	Parkinson disease	P01211	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	IDA	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	TAKRU|Ensembl=ENSTRUG00000017153|UniProtKB=H2V408	Uncharacterized protein	ISS			PTHR10410:SF5	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 14
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04393	Ras Pathway	P04573	Elk-1	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	IDA	11050086	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	TAKRU|Ensembl=ENSTRUG00000016101|UniProtKB=H2UW32	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01227	20S proteasome	BOVIN|Gene=PSMB1|UniProtKB=Q2TBX6	Proteasome subunit beta type-1	ISS	12859888	PubMed	PTHR11599:SF59	PROTEASOME SUBUNIT BETA TYPE-1
P00005	Angiogenesis	P00182	p38MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	ORYSJ|EnsemblGenome=OS01G0772600|UniProtKB=Q8S1J0	Os01g0772600 protein	IDA	11437445	PubMed	PTHR11909:SF153	SUBFAMILY NOT NAMED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00057	Wnt signaling pathway	P01440	Cadherin	BOVIN|Gene=CDH13|UniProtKB=Q3B7N0	Cadherin-13	ISS	8120095	PubMed	PTHR24027:SF80	CADHERIN-13
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	HUMAN|HGNC=4595|UniProtKB=Q14832	Metabotropic glutamate receptor 3	ISS	20012997	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00048	PI3 kinase pathway	P01192	p110	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	XENTR|Xenbase=XB-GENE-957124|UniProtKB=F7BDN8	Uncharacterized protein	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00048	PI3 kinase pathway	P01192	p110	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-040426-2427|UniProtKB=F1Q6C0	Uncharacterized protein (Fragment)	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00642	MEK1-2	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04393	Ras Pathway	P04556	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00298	Caspase 9	MOUSE|MGI=MGI=1277950|UniProtKB=Q8C3Q9	Caspase-9	ISS	9390557	PubMed	PTHR10454:SF157	CASPASE-9
P00047	PDGF signaling pathway	P01174	Rho	MOUSE|MGI=MGI=1196332|UniProtKB=O54834	Rho GTPase-activating protein 6	ISS			PTHR12635:SF6	RHO GTPASE-ACTIVATING PROTEIN 6
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MOUSE|MGI=MGI=87902|UniProtKB=P68134	Actin, alpha skeletal muscle	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P02728	Arginine biosynthesis	P02848	N-acetylglutamate synthase	NEUCR|EnsemblGenome=EFNCRG00000007997|UniProtKB=Q1K8F6	Amino-acid acetyltransferase, mitochondrial	ISS			PTHR23342:SF4	AMINO-ACID ACETYLTRANSFERASE, MITOCHONDRIAL
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01417	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	3449797	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00519	ROCK	RAT|RGD=3590|UniProtKB=Q62868	Rho-associated protein kinase 2	ISS			PTHR22988:SF28	RHO-ASSOCIATED PROTEIN KINASE 2
P00018	EGF receptor signaling pathway	P00547	PP2A	CAEEL|WormBase=WBGene00012348|UniProtKB=O18178	Protein Phosphatase 2A (Two A) Regulatory subunit	ISS			PTHR10257:SF29	BCDNA.LD34343
P00034	Integrin signalling pathway	P00906	Rap1	MACMU|Ensembl=ENSMMUG00000014486|UniProtKB=F7GH95	Ras-related protein Rap-1A	ISS	8576107	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	PANTR|Ensembl=ENSPTRG00000006175|UniProtKB=H2R2N7	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF721	MYOSIN-6
P00029	Huntington disease	P00805	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01159	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00045	Notch signaling pathway	P01103	Next	BOVIN|Ensembl=ENSBTAG00000012817|UniProtKB=E1BDN7	Delta-like protein	ISS	7697721	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00034	Integrin signalling pathway	P00923	Arf1	DICDI|dictyBase=DDB_G0289173|UniProtKB=O00909	ADP-ribosylation factor 1	IPI	11752622	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000020224|UniProtKB=H2Q9G3	Mitogen-activated protein kinase 6	ISS	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00036	Interleukin signaling pathway	P00990	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	TAS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00047	PDGF signaling pathway	P01154	Ras	DICPU|Gene=DICPUDRAFT_51488|UniProtKB=F1A411	Putative uncharacterized protein rasC	ISS	94119591	PubMed	PTHR24070:SF251	RAS-LIKE PROTEIN RASC
P00045	Notch signaling pathway	P01106	Mastermind	HUMAN|HGNC=13632|UniProtKB=Q92585	Mastermind-like protein 1	IPI	12644465	PubMed	PTHR15692:SF19	MASTERMIND-LIKE PROTEIN 1
P00018	EGF receptor signaling pathway	P00541	Spry	HUMAN|HGNC=15533|UniProtKB=Q9C004	Protein sprouty homolog 4	ISS	10330503	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P00020	FAS signaling pathway	P00615	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00053	T cell activation	P01335	jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	3136397	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00034	Integrin signalling pathway	P00912	Arp2/3	MONDO|Ensembl=ENSMODG00000019755|UniProtKB=F6WN64	Actin-related protein 2/3 complex subunit 5	ISS	12473693	PubMed	PTHR12644:SF2	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5-LIKE PROTEIN
P00018	EGF receptor signaling pathway	P00544	c-Cbl	CANLF|Ensembl=ENSCAFG00000012100|UniProtKB=F1P861	Uncharacterized protein	ISS	4885117	gi	PTHR23007:SF5	E3 UBIQUITIN-PROTEIN LIGASE CBL
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05915	Opioid proenkephalin pathway	P05994	G-protein	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P02788	Xanthine and guanine salvage pathway	P03248	Deoxyguanosine phosphorylase	YEAST|SGD=S000004199|UniProtKB=Q05788	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00048	PI3 kinase pathway	P01182	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=69424|UniProtKB=Q99P84	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	10934033	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	ISS	14526383	PubMed	PTHR10048:SF14	PI-3 KINASE
P00048	PI3 kinase pathway	P01192	p110	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00819	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01188	Gbetagamma	DROME|FlyBase=FBgn0001105|UniProtKB=P26308	Guanine nucleotide-binding protein subunit beta-1	IC	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	PANTR|Ensembl=ENSPTRG00000033763|UniProtKB=H2QX70	Uncharacterized protein	ISS	11821900	PubMed	PTHR17502:SF4	C-C MOTIF CHEMOKINE 27
P00056	VEGF signaling pathway	P01407	Erk	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04395	Vasopressin synthesis	P04590	Vasopressin	BOVIN|Ensembl=ENSBTAG00000008026|UniProtKB=P01175	Oxytocin-neurophysin 1	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-050417-59|UniProtKB=Q15KE4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00055	Transcription regulation by bZIP transcription factor	P01390	TFIIA complex	DROME|FlyBase=FBgn0040338|UniProtKB=Q9W5B9	Transcription initiation factor IIA subunit 2-2	ISS			PTHR10966:SF0	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2
P00048	PI3 kinase pathway	P01187	IR	PANTR|Ensembl=ENSPTRG00000010386|UniProtKB=H2QF61	Tyrosine-protein kinase receptor	ISS	14500580	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CAEBR|Gene=CBG01555|UniProtKB=A8WRD7	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00018	EGF receptor signaling pathway	P00564	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	20010089	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00057	Wnt signaling pathway	P01457	GBeta	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	IDA	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00010	B cell activation	P00402	Jnk	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00059	p53 pathway	P01481	ATM/ATR	XENTR|Xenbase=XB-GENE-1012722|UniProtKB=F7DU67	Uncharacterized protein	ISS	10196661	PubMed	PTHR11139:SF69	SERINE/THREONINE-PROTEIN KINASE ATR
P00048	PI3 kinase pathway	P01187	IR	RAT|RGD=2917|UniProtKB=P15127	Insulin receptor	IDA	11182407	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00029	Huntington disease	P00785	Cytochrome c	BRADU|EnsemblGenome=BAC47751|UniProtKB=P51131	Cytochrome b/c1	IDA	15163634	PubMed	PTHR19271:SF5	CYTOCHROME B
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	IDA	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MOUSE|MGI=MGI=108023|UniProtKB=P97769	Cbp/p300-interacting transactivator 1	TAS	9865691	PubMed	PTHR17045:SF6	CBP/P300-INTERACTING TRANSACTIVATOR 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00008	Axon guidance mediated by Slit/Robo	P00355	Rho	BOVIN|Ensembl=ENSBTAG00000017200|UniProtKB=A4FV20	RHOJ protein	ISS	12932731	PubMed	PTHR24072:SF17	RHO-RELATED GTP-BINDING PROTEIN RHOJ
P00018	EGF receptor signaling pathway	P00557	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04398	p53 pathway feedback loops 2	P04657	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	DANRE|ZFIN=ZDB-GENE-040625-35|UniProtKB=Q6IQL9	Novel actin protein	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00006	Apoptosis signaling pathway	P00259	TNF	PANTR|Ensembl=ENSPTRG00000017964|UniProtKB=P61125	Lymphotoxin-alpha	ISS			PTHR11471:SF31	LYMPHOTOXIN-ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=12787|UniProtKB=P56706	Protein Wnt-7b	TAS	8717036	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	HUMAN|HGNC=8590|UniProtKB=Q13153	Serine/threonine-protein kinase PAK 1	ISS	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	MACMU|Ensembl=ENSMMUG00000009679|UniProtKB=F6YBQ8	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00010	B cell activation	P00381	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT1G10210|UniProtKB=Q39021	Mitogen-activated protein kinase 1	ISS	11707292	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00052	TGF-beta signaling pathway	P01289	I-Smads	MACMU|Ensembl=ENSMMUG00000012770|UniProtKB=F7EIP8	Mothers against decapentaplegic homolog	ISS	9335505	PubMed	PTHR13703:SF27	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 7
P04393	Ras Pathway	P04570	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IDA	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00807	Actin	HUMAN|HGNC=143|UniProtKB=P68032	Actin, alpha cardiac muscle 1	IDA	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00021	FGF signaling pathway	P00624	14-3-3	XENTR|Xenbase=XB-GENE-951350|UniProtKB=Q0V9W8	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	ISS	10407019	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00024	Glycolysis	P00680	Phosphoglyceromutase	HUMAN|HGNC=8889|UniProtKB=P15259	Phosphoglycerate mutase 2	RCA			PTHR11931:SF8	PHOSPHOGLYCERATE MUTASE 2
P00052	TGF-beta signaling pathway	P01287	BAMBI	DANRE|ZFIN=ZDB-GENE-040704-30|UniProtKB=Q6GQM7	BMP and activin membrane-bound inhibitor homolog	ISS			PTHR15505:SF1	BMP AND ACTIVIN MEMBRANE-BOUND INHIBITOR HOMOLOG
P00029	Huntington disease	P00788	Calpain	CANLF|Ensembl=ENSCAFG00000013830|UniProtKB=F6UZV8	Uncharacterized protein	ISS	11675509	PubMed	PTHR10183:SF284	CALPAIN-1 CATALYTIC SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	BOVIN|Ensembl=ENSBTAG00000013498|UniProtKB=Q75Z89	5-hydroxytryptamine receptor 2A	ISS	8143856	PubMed	PTHR24247:SF30	5-HYDROXYTRYPTAMINE RECEPTOR 2A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	11591316	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00029	Huntington disease	P00810	GAPDH	MOUSE|MGI=MGI=3782011|UniProtKB=S4R1W1	Glyceraldehyde-3-phosphate dehydrogenase	IPI	8612237	PubMed	PTHR10836:SF51	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE
P00005	Angiogenesis	P00224	PDGF	CANLF|Gene=PDGFB|UniProtKB=Q6Q7I7	Platelet-derived growth factor subunit B	ISS			PTHR11633:SF2	PLATELET-DERIVED GROWTH FACTOR SUBUNIT B
P00019	Endothelin signaling pathway	P00568	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IGI	94179345	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P05913	Enkephalin release	P05972	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CANLF|Ensembl=ENSCAFG00000002044|UniProtKB=P63210	Guanine nucleotide-binding protein G(T) subunit gamma-T1	ISS	3100519	PubMed	PTHR13809:SF26	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT GAMMA-T1
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00034	Integrin signalling pathway	P00920	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	MOUSE|MGI=MGI=103038|UniProtKB=P42227	Signal transducer and activator of transcription 3	TAS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00021	FGF signaling pathway	P00644	p38	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00005	Angiogenesis	P00223	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	RCA			PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00562	p38	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00010	B cell activation	P00375	Calmodulin	ANOGA|EnsemblGenome=AGAP010957|UniProtKB=Q7QGY7	AGAP010957-PA (Fragment)	ISS	10487978	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	XENTR|Xenbase=XB-GENE-969601|UniProtKB=Q28H40	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00005	Angiogenesis	P00252	Grb2	DANRE|ZFIN=ZDB-GENE-040426-1975|UniProtKB=Q6PC73	Growth factor receptor-bound protein 2	ISS	http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd	Website	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04398	p53 pathway feedback loops 2	P04654	Rb	HUMAN|HGNC=9893|UniProtKB=P28749	Retinoblastoma-like protein 1	ISS			PTHR13742:SF20	RETINOBLASTOMA-LIKE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	MOUSE|MGI=MGI=103038|UniProtKB=P42227	Signal transducer and activator of transcription 3	TAS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	IC	91056091	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	HUMAN|HGNC=11641|UniProtKB=Q9NQB0	Transcription factor 7-like 2	IEP	12176738	PubMed	PTHR10373:SF32	TRANSCRIPTION FACTOR 7-LIKE 2
P00006	Apoptosis signaling pathway	P00321	HSP70	PHYIT|EnsemblGenome=PITG_00527|UniProtKB=D0MR13	Luminal-binding protein 3	ISS	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00006	Apoptosis signaling pathway	P00302	ATF	MONDO|Ensembl=ENSMODG00000015970|UniProtKB=F7FD05	Uncharacterized protein	ISS	11752053	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00029	Huntington disease	P00807	Actin	CANLF|Ensembl=ENSCAFG00000008756|UniProtKB=F2Z4N8	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	HUMAN|HGNC=3373|UniProtKB=Q09472	Histone acetyltransferase p300	ISS	10823891	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02917	Ribonucleoside triphosphate Reductase	BACTN|EnsemblGenome=BT_1998|UniProtKB=Q8A688	Anaerobic ribonucleoside-triphosphate reductase	ISS			PTHR21075:SF0	ANAEROBIC RIBONUCLEOSIDE-TRIPHOSPHATE REDUCTASE
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01179	PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01332	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05915	Opioid proenkephalin pathway	P05993	AC	MOUSE|MGI=MGI=102891|UniProtKB=P51829	Adenylate cyclase type 7	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00059	p53 pathway	P04633	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00474	Wnt	CHICK|Ensembl=ENSGALG00000005396|UniProtKB=Q2LMP1	Protein Wnt-3a	IDA	8717036	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DICDI|dictyBase=DDB_G0274383|UniProtKB=Q8MLZ3	cGMP-dependent 3',5'-cGMP phosphodiesterase A	IC	2372396	PubMed	PTHR45452:SF1	SUBFAMILY NOT NAMED
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MACMU|Ensembl=ENSMMUG00000009341|UniProtKB=F6UA54	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05913	Enkephalin release	P05974	G-Protein (i)	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00046	Oxidative stress response	P01132	c-jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00006	Apoptosis signaling pathway	P00310	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	DEIRA|EnsemblGenome=DR_0340|UniProtKB=Q9RXH3	Folyl-polyglutamate synthetase	ISS			PTHR11136:SF0	DIHYDROFOLATE SYNTHETASE-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00054	Toll receptor signaling pathway	P01369	MKK1	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00021	FGF signaling pathway	P00630	RKIP	MOUSE|MGI=MGI=1344408|UniProtKB=P70296	Phosphatidylethanolamine-binding protein 1	IGI	11034991	PubMed	PTHR11362:SF10	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	RCA	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MACMU|Ensembl=ENSMMUG00000009763|UniProtKB=F6ZIC3	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF368	MYOSIN-8
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00060	Ubiquitin proteasome pathway	P01492	E1	BOVIN|Ensembl=ENSBTAG00000002676|UniProtKB=A2VE14	SUMO-activating enzyme subunit 1	ISS			PTHR10953:SF162	SUMO-ACTIVATING ENZYME SUBUNIT 1
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00541	Spry	MOUSE|MGI=MGI=1345138|UniProtKB=Q9QXV8	Protein sprouty homolog 2	IGI	12225946	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00024	Glycolysis	P00679	Aldolase	MOUSE|MGI=MGI=1931052|UniProtKB=A6ZI47	Fructose-bisphosphate aldolase	ISS	4812352	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	8457205	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	SCHPO|PomBase=SPAC6G9.11|UniProtKB=Q92356	Synaptobrevin homolog 1	ISS	93386758	PubMed	PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	ORNAN|Ensembl=ENSOANG00000006699|UniProtKB=F6ULE6	Uncharacterized protein	ISS	12145413	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00005	Angiogenesis	P00256	PLC-gamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P06959	CCKR signaling map	P07099	PKA-Calpha/beta/gamma	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	RCA	7935349	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014262|UniProtKB=F7BYS8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00029	Huntington disease	P00776	c-Jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00018	EGF receptor signaling pathway	P00564	Rac	XENTR|Xenbase=XB-GENE-957540|UniProtKB=F7B5I9	Uncharacterized protein	ISS			PTHR24072:SF17	RHO-RELATED GTP-BINDING PROTEIN RHOJ
P06209	ALP23B signaling pathway	P06221	MED	DROME|FlyBase=FBgn0011655|UniProtKB=O62609	Mothers against decapentaplegic homolog	IEA	http://flybase.org/reports/FBgn0011655.html	Website	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PRIPA|Gene=PPA23459|UniProtKB=H3FMF2	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01173	STAT	MACMU|Ensembl=ENSMMUG00000005617|UniProtKB=F6WDY6	Signal transducer and activator of transcription	ISS	94255416	PubMed	PTHR11801:SF19	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	BOVIN|Ensembl=ENSBTAG00000015670|UniProtKB=E1B7J7	Uncharacterized protein	ISS	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00005	Angiogenesis	P00210	eNOS	HUMAN|HGNC=7876|UniProtKB=P29474	Nitric oxide synthase, endothelial	IEP	10435050	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CIOIN|Ensembl=ENSCING00000001377|UniProtKB=F6SDC9	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00034	Integrin signalling pathway	P00944	Actin	MONDO|Ensembl=ENSMODG00000023202|UniProtKB=F7EU36	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00001	Adrenaline and noradrenaline biosynthesis	P00062	TH	HUMAN|HGNC=11782|UniProtKB=P07101	Tyrosine 3-monooxygenase	ISS	12814656	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00034	Integrin signalling pathway	P00945	Parvin	MOUSE|MGI=MGI=2153063|UniProtKB=Q9ES46	Beta-parvin	ISS	11331308	PubMed	PTHR12114:SF7	BETA-PARVIN
P00034	Integrin signalling pathway	P00925	MEK	HUMAN|HGNC=6843|UniProtKB=P46734	Dual specificity mitogen-activated protein kinase kinase 3	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	DROME|FlyBase=FBgn0010341|UniProtKB=P40793	Cdc42 homolog	ISS	12932731	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00049	Parkinson disease	P01219	SAPK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00648	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00059	p53 pathway	P01486	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06737	p300	MOUSE|MGI=MGI=1276116|UniProtKB=B2RWS6	Histone acetyltransferase p300	RCA	8413673	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02762	Pentose phosphate pathway	P03082	Transketolase	ECOLI|EcoGene=EG11427|UniProtKB=P27302	Transketolase 1	ISS	8241274	PubMed	PTHR43522:SF8	TRANSKETOLASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00036	Interleukin signaling pathway	P00990	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00398	IP3R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04393	Ras Pathway	P04570	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	PANTR|Ensembl=ENSPTRG00000006631|UniProtKB=H2Q8S3	Ribosomal protein S6 kinase	ISS	9687510	PubMed	PTHR24351:SF115	RIBOSOMAL PROTEIN S6 KINASE ALPHA-5
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00049	Parkinson disease	P01219	SAPK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	NAS	7600581	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00048	PI3 kinase pathway	P01177	P110ACT	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00384	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IDA	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P02785	Valine biosynthesis	P03217	Dihydroxy isovalerate reductoisomerase	RHOBA|EnsemblGenome=RB9869|UniProtKB=Q7UKY0	Ketol-acid reductoisomerase	ISS			PTHR21371:SF1	KETOL-ACID REDUCTOISOMERASE, CHLOROPLASTIC
P00038	JAK/STAT signaling pathway	P01027	STAT	BOVIN|Gene=STAT5A|UniProtKB=Q95115	Signal transducer and activator of transcription 5A	ISS	14662325	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00034	Integrin signalling pathway	P00906	Rap1	MACMU|Ensembl=ENSMMUG00000009603|UniProtKB=F6ZQ12	DnaJ homolog subfamily C member 27 isoform 1	ISS			PTHR24073:SF269	DNAJ HOMOLOG SUBFAMILY C MEMBER 27
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	8838325	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P06959	CCKR signaling map	P07085	RAF1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	RCA	11237210	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00624	14-3-3	ORNAN|Ensembl=ENSOANG00000006084|UniProtKB=F7BU66	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF14	14-3-3 PROTEIN SIGMA
P00012	Cadherin signaling pathway	P00475	Frizzled	MACMU|Ensembl=ENSMMUG00000013215|UniProtKB=F6X7X4	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF31	FRIZZLED-7
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	PLAF7|EnsemblGenome=PF14_0352|UniProtKB=Q8IL94	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	DICDI|dictyBase=DDB_G0281385|UniProtKB=P32253	Ras-like protein rasC	ISS	94119591	PubMed	PTHR24070:SF251	RAS-LIKE PROTEIN RASC
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MOUSE|MGI=MGI=1336171|UniProtKB=Q9DAS9	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IDA	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00034	Integrin signalling pathway	P00948	Rho	XENTR|Xenbase=XB-GENE-489222|UniProtKB=Q28GJ8	Ras homolog gene family, member A	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P02723	Adenine and hypoxanthine salvage pathway	P02811	Adenosine deaminase	EMENI|EnsemblGenome=CADANIAG00006939|UniProtKB=Q8X1T6	Adenine deaminase	ISS			PTHR43114:SF2	ADENINE DEAMINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00018	EGF receptor signaling pathway	P00539	14-3-3	XENTR|Xenbase=XB-GENE-949031|UniProtKB=Q28DR3	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	ISS	10407019	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P04393	Ras Pathway	P04572	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00114	actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g242065|UniProtKB=A7S0V7	Predicted protein	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00906	Rap1	HUMAN|HGNC=9855|UniProtKB=P62834	Ras-related protein Rap-1A	ISS	1904317	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000003043|UniProtKB=P63212	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00012	Cadherin signaling pathway	P00474	Wnt	CHICK|Ensembl=ENSGALG00000005401|UniProtKB=Q3L251	Protein Wnt	IDA	11266476	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MOUSE|MGI=MGI=1321394|UniProtKB=Q9WV56	Growth/differentiation factor 2	TAS	9759503	PubMed	PTHR11848:SF157	GROWTH/DIFFERENTIATION FACTOR 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	MOUSE|MGI=MGI=1347078|UniProtKB=O70293	G protein-coupled receptor kinase 6	IDA	12032308	PubMed	PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P04393	Ras Pathway	P04570	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000003128|UniProtKB=H2Q2V4	Uncharacterized protein	ISS	12181435	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00029	Huntington disease	P00805	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ORYSJ|EnsemblGenome=OS03G0718100|UniProtKB=Q10DV7	Actin-1	IC	14684598	PubMed	PTHR11937:SF364	ACTIN-11
P02750	Lipoate_biosynthesis	P03004	Lipoate synthase	BOVIN|Ensembl=ENSBTAG00000014520|UniProtKB=Q5BIP7	Lipoyl synthase, mitochondrial	ISS			PTHR10949:SF0	LIPOYL SYNTHASE, MITOCHONDRIAL
P00049	Parkinson disease	P01242	Casein kinase I	DANRE|ZFIN=ZDB-GENE-040426-2385|UniProtKB=Q6P3K7	Casein kinase I isoform delta-B	ISS	10617630	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00018	EGF receptor signaling pathway	P00551	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00775	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	4757952	gi	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	DAPPU|EnsemblGenome=DAPPUDRAFT_301818|UniProtKB=E9I1I7	Putative uncharacterized protein	ISS	20148920	PubMed	PTHR24070:SF385	GTPASE HRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	TAS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02771	Pyrimidine Metabolism	P03129	Aminotransferase	EMENI|EnsemblGenome=CADANIAG00008938|UniProtKB=P14010	4-aminobutyrate aminotransferase	IEP	2505051	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IPI	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00557	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	129387	gi	PTHR10048:SF14	PI-3 KINASE
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IDA	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04398	p53 pathway feedback loops 2	P04665	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P02762	Pentose phosphate pathway	P03082	Transketolase	YEAST|SGD=S000006278|UniProtKB=P23254	Transketolase 1	RCA			PTHR43522:SF2	TRANSKETOLASE 1-RELATED
P00018	EGF receptor signaling pathway	P00555	MKK4,7	RAT|RGD=1560043|UniProtKB=Q4KSH7	Dual specificity mitogen-activated protein kinase kinase 7	ISS	15039780	PubMed	PTHR24361:SF387	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7
P00034	Integrin signalling pathway	P00924	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	12068308	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	RAT|RGD=3305|UniProtKB=P06765	Platelet factor 4	ISS	9910486	gi	PTHR10179:SF43	PLATELET FACTOR 4
P00047	PDGF signaling pathway	P01162	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P06587	Nicotine pharmacodynamics pathway	P06607	EPB41	MOUSE|MGI=MGI=95401|UniProtKB=P48193	Protein 4.1	RCA	12181426	PubMed	PTHR23280:SF12	PROTEIN 4.1
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000014498|UniProtKB=F7GEI8	Uncharacterized protein	ISS	14507926	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01194	S6K	RAT|RGD=1305144|UniProtKB=D4AE24	Ribosomal protein S6 kinase	ISS	15116068	PubMed	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00381	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	12068308	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P04398	p53 pathway feedback loops 2	P04661	PI3K	CAEEL|WormBase=WBGene00006932|UniProtKB=Q9TXI7	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	11927551	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00034	Integrin signalling pathway	P00907	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P06959	CCKR signaling map	P07113	ITGB1	HUMAN|HGNC=6153|UniProtKB=P05556	Integrin beta-1	RCA	16547500	PubMed	PTHR10082:SF28	INTEGRIN BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00047	PDGF signaling pathway	P01142	p90RSK	MACMU|Ensembl=ENSMMUG00000022111|UniProtKB=F7H7W3	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04580	TRH Receptor	CHICK|Gene=TRHR|UniProtKB=O93603	Thyrotropin-releasing hormone receptor	ISS	14599121	PubMed	PTHR24243:SF115	THYROTROPIN-RELEASING HORMONE RECEPTOR
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01408	Akt/PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00036	Interleukin signaling pathway	P00977	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00049	Parkinson disease	P01228	DAT	MOUSE|MGI=MGI=94862|UniProtKB=Q61327	Sodium-dependent dopamine transporter	TAS	15135042	PubMed	PTHR11616:SF38	SODIUM-DEPENDENT DOPAMINE TRANSPORTER
P06959	CCKR signaling map	P07084	MEN1	HUMAN|HGNC=7010|UniProtKB=O00255	Menin	RCA	12105855	PubMed	PTHR12693:SF3	MENIN
P00010	B cell activation	P00391	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00221	JNK1	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00049	Parkinson disease	P01208	Hsp70	ORYSJ|EnsemblGenome=OS03G0276500|UniProtKB=Q10NA9	70 kDa heat shock protein	IDA	12150907	PubMed	PTHR19375:SF243	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00040	Metabotropic glutamate receptor group II pathway	G01540	BDNF	DANRE|ZFIN=ZDB-GENE-000412-1|UniProtKB=Q6NZ01	Bdnf protein	ISS	11724916	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05912	Dopamine receptor mediated signaling pathway	P05957	K+ channel	BOVIN|Ensembl=ENSBTAG00000018193|UniProtKB=E1BHX8	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	TAS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00560	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00023	General transcription regulation	P00668	TFIIB	STRPU|EnsemblGenome=SPU_011000|UniProtKB=W4Y5K3	Uncharacterized protein	ISS			PTHR12458:SF8	CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20
P06587	Nicotine pharmacodynamics pathway	P06608	DDC	PANTR|Ensembl=ENSPTRG00000019189|UniProtKB=H2QUK8	Uncharacterized protein	ISS	90339966	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00036	Interleukin signaling pathway	P00981	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	TAS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00029	Huntington disease	P00786	ARF	BOVIN|Ensembl=ENSBTAG00000007725|UniProtKB=P84080	ADP-ribosylation factor 1	ISS	11752622	PubMed	PTHR11711:SF294	ADP-RIBOSYLATION FACTOR 3
P00018	EGF receptor signaling pathway	P00543	ERK1-2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00060	Ubiquitin proteasome pathway	P01491	E2	MOUSE|MGI=MGI=1930715|UniProtKB=P62838	Ubiquitin-conjugating enzyme E2 D2	ISS			PTHR24068:SF40	UBIQUITIN-CONJUGATING ENZYME E2 D2-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IDA	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	CANLF|Ensembl=ENSCAFG00000004381|UniProtKB=J9JH96	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	YEAST|SGD=S000005762|UniProtKB=P07807	Dihydrofolate reductase	ISS			PTHR11548:SF3	DIHYDROFOLATE REDUCTASE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P06959	CCKR signaling map	P07226	CCK-8	HUMAN|HGNC=1569|UniProtKB=P06307	Cholecystokinin	RCA		PubMed	PTHR10786:SF0	CHOLECYSTOKININ
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P02728	Arginine biosynthesis	P02846	Ornithine carbamoyl transferase	EMENI|EnsemblGenome=CADANIAG00006048|UniProtKB=P11803	Ornithine carbamoyltransferase, mitochondrial	ISS			PTHR11405:SF1	ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IDA	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MACMU|Ensembl=ENSMMUG00000013656|UniProtKB=F7GI70	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF126	FRIZZLED-5
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	TAKRU|Ensembl=ENSTRUG00000014690|UniProtKB=H2UKR9	Uncharacterized protein	ISS	11248120	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00018	EGF receptor signaling pathway	P00561	STAT	MOUSE|MGI=MGI=103038|UniProtKB=P42227	Signal transducer and activator of transcription 3	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	IDA	9199552	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00036	Interleukin signaling pathway	P00964	p90RSK	ORNAN|Ensembl=ENSOANG00000010658|UniProtKB=F6V2V1	Uncharacterized protein	ISS	2779569	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DROME|FlyBase=FBgn0030011|UniProtKB=Q9W3J1	Gbeta5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00049	Parkinson disease	P01207	PLD2	HUMAN|HGNC=9068|UniProtKB=O14939	Phospholipase D2	IDA	9538008	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00005	Angiogenesis	P00182	p38MAPK	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	ISS	20451058	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=1309895|UniProtKB=G3V8N7	Protein Pcdhb8	ISS	8120095	PubMed	PTHR24028:SF100	MCG141292-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05957	K+ channel	RAT|RGD=61997|UniProtKB=O54912	Potassium channel subfamily K member 3	ISS	15282272	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00047	PDGF signaling pathway	P01162	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	RAT|RGD=3784|UniProtKB=P61265	Syntaxin-1B	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00010	B cell activation	P00379	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04393	Ras Pathway	P04542	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00059	p53 pathway	P04609	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00556	PLCgamma	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	IC	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00047	PDGF signaling pathway	P01155	Jak	PANTR|Ensembl=ENSPTRG00000020744|UniProtKB=H2QWZ4	Tyrosine-protein kinase	ISS	22482294	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	BOVIN|Ensembl=ENSBTAG00000009778|UniProtKB=E1BMX0	Uncharacterized protein	ISS	9869449	PubMed	PTHR24070:SF186	GTPASE KRAS
P00010	B cell activation	P00376	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	3035212	PubMed	PTHR24070:SF385	GTPASE HRAS
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00471	Cadherin	XENTR|Xenbase=XB-GENE-482277|UniProtKB=F6QAX3	Uncharacterized protein	ISS	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00057	Wnt signaling pathway	P01444	Wnt	PANTR|Ensembl=ENSPTRG00000015034|UniProtKB=H2QMT4	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00052	TGF-beta signaling pathway	P01279	Smurfs	MOUSE|MGI=MGI=1923038|UniProtKB=Q9CUN6	E3 ubiquitin-protein ligase SMURF1	TAS	11252892	PubMed	PTHR11254:SF293	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	STRPU|EnsemblGenome=SPU_025182|UniProtKB=W4ZAK5	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	IDA	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01311	Raf	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS	12068308	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P04393	Ras Pathway	P04566	Stat 1/3	TAKRU|Ensembl=ENSTRUG00000015348|UniProtKB=H2UQK9	Signal transducer and activator of transcription	ISS	15452141	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00925	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IDA	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00056	VEGF signaling pathway	P01425	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00018	EGF receptor signaling pathway	P00541	Spry	RAT|RGD=1311472|UniProtKB=Q5HZA2	Protein Spry2	ISS	12225946	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P04393	Ras Pathway	P04558	p38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IDA	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P02729	Ascorbate degradation	P02849	L-xylulose kinase	STRCO|EnsemblGenome=CAD55165|UniProtKB=Q9RK00	Xylulose kinase	ISS			PTHR43095:SF5	SUBFAMILY NOT NAMED
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	DROME|FlyBase=FBgn0032945|UniProtKB=Q9VIC9	10-formyltetrahydrofolate dehydrogenase	IC			PTHR11699:SF190	10-FORMYLTETRAHYDROFOLATE DEHYDROGENASE
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00219	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00015	Circadian clock system	G01499	per	PANTR|Ensembl=ENSPTRG00000000099|UniProtKB=H2R1W8	Uncharacterized protein	ISS	15700718	PubMed	PTHR11269:SF13	PERIOD CIRCADIAN PROTEIN HOMOLOG 3
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00057	Wnt signaling pathway	P01443	Phospholipase C	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=2685011|UniProtKB=E9PVD3	Protocadherin-16	ISS	8120095	PubMed	PTHR43956:SF6	PROTOCADHERIN-16
P04398	p53 pathway feedback loops 2	P04669	ATM	CANLF|Ensembl=ENSCAFG00000007863|UniProtKB=E2QXA4	Uncharacterized protein	ISS	10196661	PubMed	PTHR11139:SF69	SERINE/THREONINE-PROTEIN KINASE ATR
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_114976|UniProtKB=C3YP58	Putative uncharacterized protein	IDA	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	IDA	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	XENTR|Xenbase=XB-GENE-961282|UniProtKB=Q6DF43	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00034	Integrin signalling pathway	P00931	Integrin beta	CANLF|Ensembl=ENSCAFG00000013735|UniProtKB=F1PPG5	Integrin beta	IDA	5805343	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00059	p53 pathway	P01480	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00029	Huntington disease	P00786	ARF	TAKRU|Ensembl=ENSTRUG00000003085|UniProtKB=H2S481	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF119	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 4C
P00047	PDGF signaling pathway	P01145	c-fos	BOVIN|Ensembl=ENSBTAG00000004322|UniProtKB=O77628	Proto-oncogene c-Fos	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04393	Ras Pathway	P04563	Ets	BOVIN|Ensembl=ENSBTAG00000002341|UniProtKB=A5PJG9	ETS1 protein	ISS	15699632	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02738	De novo purine biosynthesis	P02907	dADP kinase	RAT|RGD=61896|UniProtKB=O88426	Nucleoside diphosphate kinase 6 (Fragment)	ISS			PTHR11349:SF70	NUCLEOSIDE DIPHOSPHATE KINASE 6
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000014751|UniProtKB=H2R8D8	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	TAS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01443	Phospholipase C	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00008	Axon guidance mediated by Slit/Robo	P00351	Cxcr4	CANLF|Ensembl=ENSCAFG00000005109|UniProtKB=Q3LSL6	C-X-C chemokine receptor type 4	ISS	11591799	PubMed	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CHICK|Ensembl=ENSGALG00000008512|UniProtKB=F1P0S6	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00025	Hedgehog signaling pathway	P00692	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00046	Oxidative stress response	P01135	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00020	FAS signaling pathway	P00618	CAD	RAT|RGD=620335|UniProtKB=Q99N34	DNA fragmentation factor subunit beta	TAS	10739646	PubMed	PTHR13067:SF2	DNAATION FACTOR-RELATED PROTEIN 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00006	Apoptosis signaling pathway	P00302	ATF	RAT|RGD=620218|UniProtKB=P15337	Cyclic AMP-responsive element-binding protein 1	ISS	11752053	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01149	MNK1/2	HUMAN|HGNC=7110|UniProtKB=Q9BUB5	MAP kinase-interacting serine/threonine-protein kinase 1	ISS	9155018	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IGI	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00010	B cell activation	P00389	mIgM	BOVIN|Ensembl=ENSBTAG00000001219|UniProtKB=G5E513	Uncharacterized protein	IDA			PTHR23266:SF120	IG MU CHAIN C REGION
P00029	Huntington disease	P00774	Dynein complex	MOUSE|MGI=MGI=107714|UniProtKB=Q91XQ0	Dynein heavy chain 8, axonemal	IPI	9454836	PubMed	PTHR10676:SF344	DYNEIN HEAVY CHAIN 8, AXONEMAL
P00018	EGF receptor signaling pathway	P00543	ERK1-2	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	IGI	10514528	PubMed	PTHR24055:SF330	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00916	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00059	p53 pathway	G04694	p110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00976	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	PANTR|Ensembl=ENSPTRG00000007605|UniProtKB=H2QAA6	Nucleoside diphosphate kinase	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P02776	Serine glycine biosynthesis	P03159	Phosphoserine phosphatase	MONDO|Ensembl=ENSMODG00000006585|UniProtKB=F7B7E7	Uncharacterized protein	ISS			PTHR43344:SF2	PHOSPHOSERINE PHOSPHATASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	MOUSE|MGI=MGI=1338071|UniProtKB=O88351	Inhibitor of nuclear factor kappa-B kinase subunit beta	IDA	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00034	Integrin signalling pathway	P00911	B-Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	ISS	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00057	Wnt signaling pathway	P01443	Phospholipase C	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00049	Parkinson disease	P01224	UbcH7	BOVIN|Gene=UBE2L3|UniProtKB=Q3MHP1	Ubiquitin-conjugating enzyme E2 L3	RCA			PTHR24068:SF67	UBIQUITIN-CONJUGATING ENZYME E2 L3
P00010	B cell activation	P00384	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01428	Frizzled	DANRE|ZFIN=ZDB-GENE-990415-218|UniProtKB=B3DIG4	Frizzled homolog 8c	IDA	11212302	PubMed	PTHR11309:SF126	FRIZZLED-5
P00018	EGF receptor signaling pathway	P00564	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000006232|UniProtKB=H2Q845	Serine/threonine-protein kinase	ISS	12393506	PubMed	PTHR22968:SF9	SERINE/THREONINE-PROTEIN KINASE D1
P00046	Oxidative stress response	P01135	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	TAS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00005	Angiogenesis	P00243	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00177	Nectin 1alpha C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000015939|UniProtKB=F1MQJ3	Uncharacterized protein	ISS	12376527	PubMed	PTHR23277:SF69	NECTIN-1
P00019	Endothelin signaling pathway	P00566	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	20027584	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	IDA	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000015240|UniProtKB=F6VUY3	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00053	T cell activation	P01320	PLC-gamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00807	Actin	TRIVA|Gene=TVAG_337240|UniProtKB=P90623	Actin	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	MOUSE|MGI=MGI=103038|UniProtKB=P42227	Signal transducer and activator of transcription 3	TAS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00018	EGF receptor signaling pathway	P00547	PP2A	ARATH|TAIR=AT3G26030|UniProtKB=Q9ZQY6	Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B' delta isoform	ISS			PTHR10257:SF46	SERINE/THREONINE PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B' DELTA ISOFORM-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	ISS	8557110	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00018	EGF receptor signaling pathway	G01511	SPRY	PANTR|Ensembl=ENSPTRG00000017360|UniProtKB=H2QRP3	Uncharacterized protein	ISS	99264295	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05912	Dopamine receptor mediated signaling pathway	P05944	COMT	RAT|RGD=2379|UniProtKB=P22734	Catechol O-methyltransferase	ISS	12842307	PubMed	PTHR43836:SF3	CATECHOL O-METHYLTRANSFERASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00036	Interleukin signaling pathway	P00973	PKB	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00367	NFAT	PANTR|Ensembl=ENSPTRG00000006218|UniProtKB=H2Q834	Uncharacterized protein	ISS	12787506	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	DICPU|Gene=DICPUDRAFT_57324|UniProtKB=F0ZVH9	Putative uncharacterized protein rasS	ISS	94119591	PubMed	PTHR24070:SF380	RAS-LIKE PROTEIN RASS
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176910	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001749|UniProtKB=H2Q0Q4	Uncharacterized protein	ISS	11976940	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00047	PDGF signaling pathway	P01168	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT1G10210|UniProtKB=Q39021	Mitogen-activated protein kinase 1	IDA	11707292	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	MACMU|Ensembl=ENSMMUG00000020037|UniProtKB=F7GDJ3	Anti-Muellerian hormone type-2 receptor	ISS	9759503	PubMed	PTHR23255:SF49	ANTI-MUELLERIAN HORMONE TYPE-2 RECEPTOR
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	MYCTU|EnsemblGenome=Rv2763c|UniProtKB=P9WNX1	Dihydrofolate reductase	ISS			PTHR22778:SF16	DIHYDROFOLATE REDUCTASE
P02742	Tetrahydrofolate biosynthesis	P02944	Phosphoribosylglycinamide formyltransferase	FUSNN|EnsemblGenome=FN0985|UniProtKB=Q8REV4	Phosphoribosylglycinamide formyltransferase	ISS			PTHR43369:SF2	PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00059	p53 pathway	P04633	P110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P06214	GBB signaling pathway	P06299	MED	DROME|FlyBase=FBgn0011648|UniProtKB=P42003	Protein mothers against dpp	RCA			PTHR13703:SF40	PROTEIN MOTHERS AGAINST DPP
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	BOVIN|Ensembl=ENSBTAG00000033153|UniProtKB=F1MG21	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	XENTR|Xenbase=XB-GENE-489222|UniProtKB=Q28GJ8	Ras homolog gene family, member A	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00006	Apoptosis signaling pathway	P00260	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01185	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	IC	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00059	p53 pathway	G04703	Apaf	BOVIN|Ensembl=ENSBTAG00000021661|UniProtKB=F1MUW4	Apoptotic protease-activating factor 1	ISS	14526190	PubMed	PTHR22845:SF5	APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04395	Vasopressin synthesis	P04589	Signal Peptidase	MONDO|Ensembl=ENSMODG00000003782|UniProtKB=F6RRN6	Uncharacterized protein	ISS	1546959	PubMed	PTHR12804:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 3
P02742	Tetrahydrofolate biosynthesis	P02951	GTP cyclohydrolase	HUMAN|HGNC=4193|UniProtKB=P30793	GTP cyclohydrolase 1	ISS			PTHR11109:SF0	GTP CYCLOHYDROLASE 1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	91298951	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00006	Apoptosis signaling pathway	P00260	AKT	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	MACMU|Ensembl=ENSMMUG00000010173|UniProtKB=F7AGU8	Presenilin	ISS	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P00047	PDGF signaling pathway	P01161	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	YEAST|SGD=S000000028|UniProtKB=P31109	Synaptobrevin homolog 1	IC			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	NEUCR|EnsemblGenome=EFNCRG00000006348|UniProtKB=P48580	Serine/threonine-protein phosphatase PP2A catalytic subunit	ISS			PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	IC	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	BOVIN|Ensembl=ENSBTAG00000006495|UniProtKB=P11017	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	PANTR|Ensembl=ENSPTRG00000010806|UniProtKB=H2QG00	Low density lipoprotein receptor-related protein 3	ISS	11907044	PubMed	PTHR44062:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 3
P04398	p53 pathway feedback loops 2	G04714	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=2136760|UniProtKB=Q91XZ8	Protein Pcdhb22	IDA	8120095	PubMed	PTHR24028:SF97	PROTOCADHERIN BETA-15
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	HUMAN|HGNC=4571|UniProtKB=P42261	Glutamate receptor 1	ISS	12941441	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00019	Endothelin signaling pathway	P00589	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	98269030	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Gene=CHRM2|UniProtKB=Q9N2A7	Muscarinic acetylcholine receptor M2 (Fragment)	ISS	10069496	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	CHICK|Ensembl=ENSGALG00000003806|UniProtKB=O93467	GTP-binding protein	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00019	Endothelin signaling pathway	P00586	Gq	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P04392	P53 pathway feedback loops 1	G04682	MDM-2	HUMAN|HGNC=6974|UniProtKB=O15151	Protein Mdm4	ISS			PTHR13844:SF20	PROTEIN MDM4
P00036	Interleukin signaling pathway	P00994	FKHRL1	MACMU|Ensembl=ENSMMUG00000020369|UniProtKB=F6UMX8	Uncharacterized protein	ISS	15031210	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00005	Angiogenesis	P00206	Wnt	CANLF|Ensembl=ENSCAFG00000032632|UniProtKB=J9P2Q5	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00005	Angiogenesis	P00206	Wnt	MACMU|Ensembl=ENSMMUG00000015709|UniProtKB=F6SLX4	Protein Wnt	ISS	14644163	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00005	Angiogenesis	P00203	Erk	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00938	Cdc42	DAPPU|EnsemblGenome=DAPPUDRAFT_306746|UniProtKB=E9GYE9	Putative uncharacterized protein	ISS	9658176	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P02781	Threonine biosynthesis	P03192	Aspartate semialdehyde dehydrogenase	AQUAE|EnsemblGenome=aq_1866|UniProtKB=O67716	Aspartate-semialdehyde dehydrogenase	ISS			PTHR10174:SF2	ASPARTATE-SEMIALDEHYDE DEHYDROGENASE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04398	p53 pathway feedback loops 2	P04665	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P06209	ALP23B signaling pathway	P06218	PUT	DROME|Gene=Dmel_CG7904|UniProtKB=A0A0B4KG59	Serine/threonine-protein kinase receptor	IEA	9395284	PubMed	PTHR23255:SF70	SERINE/THREONINE-PROTEIN KINASE RECEPTOR
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IDA	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHICK|Gene=ACTA2|UniProtKB=P08023	Actin, aortic smooth muscle	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	HUMAN|HGNC=9995|UniProtKB=O14921	Regulator of G-protein signaling 13	IDA	8756726	PubMed	PTHR10845:SF32	REGULATOR OF G-PROTEIN SIGNALING 13
P00034	Integrin signalling pathway	P00906	Rap1	XENTR|Xenbase=XB-GENE-479036|UniProtKB=Q640R7	Ras-related protein Rap-1b	ISS	8576107	PubMed	PTHR24070:SF382	RAS-RELATED PROTEIN RAP-1B
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	BRAFL|Gene=BRAFLDRAFT_123893|UniProtKB=C3XQF4	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g234494|UniProtKB=A7RU31	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00034	Integrin signalling pathway	P00951	Jnk	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00025	Hedgehog signaling pathway	P00682	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00577	PI3K	XENTR|Xenbase=XB-GENE-6067221|UniProtKB=F6Z0J4	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	TAS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00243	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04543	MEKK1/4	BOVIN|Ensembl=ENSBTAG00000020079|UniProtKB=F1N3T0	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00021	FGF signaling pathway	P00627	ERK1-2	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	MACMU|Ensembl=ENSMMUG00000006553|UniProtKB=F7HRY3	Uncharacterized protein	ISS	11212302	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00078	Alpha1A/1B/1C	HUMAN|HGNC=277|UniProtKB=P35348	Alpha-1A adrenergic receptor	IC	6323229	PubMed	PTHR24248:SF16	ALPHA-1A ADRENERGIC RECEPTOR
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00029	Huntington disease	P00810	GAPDH	PHYPA|Gene=PHYPADRAFT_150029|UniProtKB=A9TSW4	Glyceraldehyde-3-phosphate dehydrogenase	IPI			PTHR10836:SF52	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00034	Integrin signalling pathway	P00941	Integrin alpha	CANLF|Ensembl=ENSCAFG00000000060|UniProtKB=F1PIU6	Uncharacterized protein	ISS	3487386	PubMed	PTHR23220:SF90	INTEGRIN ALPHA-7
P00034	Integrin signalling pathway	P00912	Arp2/3	BOVIN|Ensembl=ENSBTAG00000015278|UniProtKB=Q5E963	Actin-related protein 2/3 complex subunit 5-like protein	ISS	12473693	PubMed	PTHR12644:SF2	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5-LIKE PROTEIN
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00029	Huntington disease	P00777	CBP	PANTR|Ensembl=ENSPTRG00000014418|UniProtKB=H2QLS0	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	MOUSE|MGI=MGI=102891|UniProtKB=P51829	Adenylate cyclase type 7	IC	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IGI	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00010	B cell activation	P00383	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04395	Vasopressin synthesis	P04590	Vasopressin	PANTR|Ensembl=ENSPTRG00000013189|UniProtKB=H2QJV1	Uncharacterized protein	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P05912	Dopamine receptor mediated signaling pathway	P05960	VAT2	BOVIN|Gene=SLC18A2|UniProtKB=Q27963	Synaptic vesicular amine transporter	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P02738	De novo purine biosynthesis	P02905	Amidophosphoribosyl transferase	SULSO|EnsemblGenome=SSO0632|UniProtKB=Q7LXR4	Amidophosphoribosyltransferase	ISS			PTHR11907:SF0	AMIDOPHOSPHORIBOSYLTRANSFERASE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01444	Wnt	MACMU|Ensembl=ENSMMUG00000006921|UniProtKB=F7EV26	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	PSEAE|EnsemblGenome=PA1566|UniProtKB=Q9I3F1	Uncharacterized protein	ISS			PTHR43785:SF1	TYPE-1 GLUTAMINE SYNTHETASE 2
P00034	Integrin signalling pathway	P00907	ERK	MONDO|Ensembl=ENSMODG00000009766|UniProtKB=F6TFL4	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00020	FAS signaling pathway	P00610	MKK4	MOUSE|MGI=MGI=1346869|UniProtKB=P47809	Dual specificity mitogen-activated protein kinase kinase 4	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00005	Angiogenesis	P00249	PAK	ORNAN|Ensembl=ENSOANG00000002406|UniProtKB=F7BAS2	Uncharacterized protein	ISS	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P02784	Tyrosine biosynthesis	P03213	Aromatic amino acid aminotransferase	ARATH|TAIR=AT4G23590|UniProtKB=Q8VYP2	Probable aminotransferase TAT4	ISS			PTHR11751:SF368	TYROSINE AMINOTRANSFERASE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	CANLF|Ensembl=ENSCAFG00000004930|UniProtKB=E2RFB5	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	RCA			PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01095	beta	BOVIN|Gene=CHRNB4|UniProtKB=Q8SPU6	Neuronal acetylcholine receptor subunit beta-4	ISS	11602335	PubMed	PTHR18945:SF385	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-4
P00045	Notch signaling pathway	P01114	Ntm	BOVIN|Ensembl=ENSBTAG00000007909|UniProtKB=F1MPE9	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MACMU|Ensembl=ENSMMUG00000009763|UniProtKB=F6ZIC3	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF368	MYOSIN-8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	RAT|RGD=61800|UniProtKB=P14842	5-hydroxytryptamine receptor 2A	IDA			PTHR24247:SF30	5-HYDROXYTRYPTAMINE RECEPTOR 2A
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	IDA	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000008719|UniProtKB=F1MZX0	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	DROME|FlyBase=FBgn0001991|UniProtKB=Q24270	Voltage-dependent calcium channel type D subunit alpha-1	IC	8838325	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	P01443	Phospholipase C	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	IDA	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00029	Huntington disease	P00777	CBP	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P02755	Methylmalonyl pathway	P03034	Methylmalonyl-CoA mutase	SULSO|EnsemblGenome=SSO2425|UniProtKB=Q97W21	Methylmalonyl-CoA mutase, alpha-subunit, chain A (McmA1)	ISS			PTHR43589:SF2	SUBFAMILY NOT NAMED
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01188	Gbetagamma	PANTR|Ensembl=ENSPTRG00000019406|UniProtKB=H2QUX9	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF26	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT GAMMA-T1
P00057	Wnt signaling pathway	P01435	SWI/SNF	MOUSE|MGI=MGI=1935147|UniProtKB=A2BH40	AT-rich interactive domain-containing protein 1A	ISS	11532957	PubMed	PTHR12656:SF12	AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 1A
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00019	Endothelin signaling pathway	P00585	ECE1-3	MOUSE|MGI=MGI=1101356|UniProtKB=Q80Z60	Endothelin-converting enzyme 2	RCA			PTHR11733:SF127	ENDOTHELIN-CONVERTING ENZYME 2
P00024	Glycolysis	P00678	Enolase	CHICK|Gene=ENO2|UniProtKB=O57391	Gamma-enolase	ISS	86042683	PubMed	PTHR11902:SF10	GAMMA-ENOLASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IDA	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00036	Interleukin signaling pathway	P00965	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	IC	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	MOUSE|MGI=MGI=94941|UniProtKB=P51141	Segment polarity protein dishevelled homolog DVL-1	TAS	11212302	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P00054	Toll receptor signaling pathway	P01375	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	DROME|FlyBase=FBgn0036790|UniProtKB=Q9VVQ1	Allatostatin C receptor 1	IDA	12181435	PubMed	PTHR24229:SF51	ALLATOSTATIN C RECEPTOR 1-RELATED
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	MONDO|Ensembl=ENSMODG00000015287|UniProtKB=F6T6M8	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00014	Cholesterol biosynthesis	P00497	Anosterol synthase	CANAL|CGD=CAL0000184383|UniProtKB=Q04782	Lanosterol synthase	ISS	P38604	SPACC	PTHR11764:SF20	LANOSTEROL SYNTHASE
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04630	PP2A	RAT|RGD=3381|UniProtKB=P62716	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05913	Enkephalin release	P05977	G-Protein (s)	MOUSE|MGI=MGI=95777|UniProtKB=Q6R0H7	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas	IC	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00053	T cell activation	P01312	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05913	Enkephalin release	P05977	G-Protein (s)	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04398	p53 pathway feedback loops 2	P04649	Myc	CANLF|Gene=MYC|UniProtKB=Q28350	Myc proto-oncogene protein	TAS	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02746	Heme biosynthesis	P02983	Hydroxymethylbilane synthase	SYNY3|EnsemblGenome=BAA17705|UniProtKB=P73660	Porphobilinogen deaminase	ISS			PTHR11557:SF5	SUBFAMILY NOT NAMED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01159	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00016	Cytoskeletal regulation by Rho GTPase	P00514	MLCK	PANTR|Ensembl=ENSPTRG00000013361|UniProtKB=H2QK55	Uncharacterized protein	ISS	600922	OMIM	PTHR45210:SF1	MYOSIN LIGHT CHAIN KINASE 2, SKELETAL/CARDIAC MUSCLE
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00006	Apoptosis signaling pathway	P00313	IKK	BOVIN|Ensembl=ENSBTAG00000007591|UniProtKB=Q95KV1	Inhibitor of nuclear factor kappa-B kinase subunit alpha	ISS	12813046	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00046	Oxidative stress response	P01129	JNK1/2	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04427	5HT4 Receptor	MOUSE|MGI=MGI=109246|UniProtKB=P97288	5-hydroxytryptamine receptor 4	ISS	15118808	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00019	Endothelin signaling pathway	P00577	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00313	IKK	MOUSE|MGI=MGI=99484|UniProtKB=Q60680	Inhibitor of nuclear factor kappa-B kinase subunit alpha	ISS	9346484	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04674	Mdm2	MOUSE|MGI=MGI=96952|UniProtKB=P23804	E3 ubiquitin-protein ligase Mdm2	IGI	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00010	B cell activation	P00384	p38	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	RCA			PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000014807|UniProtKB=F6W548	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00005	Angiogenesis	P00199	JNKK1	BOVIN|Ensembl=ENSBTAG00000012103|UniProtKB=A5PJP8	MAP2K4 protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00013	Cell cycle	P00486	Cyclin B	DANRE|ZFIN=ZDB-GENE-000406-10|UniProtKB=Q7ZU21	Cyclin B1	ISS	93040208	PubMed	PTHR10177:SF193	G2/MITOTIC-SPECIFIC CYCLIN-B1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00245	Rac	RAT|RGD=1307954|UniProtKB=Q5FVG6	Proline-rich protein 5	ISS			PTHR32428:SF4	PROLINE-RICH PROTEIN 5
P00018	EGF receptor signaling pathway	P00552	Ras	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	IGI	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	RAT|RGD=3694|UniProtKB=Q01827	Synaptic vesicular amine transporter	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CHICK|Ensembl=ENSGALG00000008880|UniProtKB=E1BYU6	Uncharacterized protein	ISS	10908612	PubMed	PTHR21230:SF39	VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A
P00056	VEGF signaling pathway	P01411	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P00029	Huntington disease	P00780	Microtubule	PHYPA|Gene=PHYPADRAFT_117822|UniProtKB=A9RQS1	Predicted protein	ISS	12932731	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P00050	Plasminogen activating cascade	P01249	pro-tPA	BOVIN|Ensembl=ENSBTAG00000001244|UniProtKB=Q28198	Tissue-type plasminogen activator	ISS	2499868	gi	PTHR44617:SF1	TISSUE-TYPE PLASMINOGEN ACTIVATOR
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00010	B cell activation	P00371	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DANRE|ZFIN=ZDB-GENE-030131-6503|UniProtKB=Q7ZUC5	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF297	PROTEIN KINASE C DELTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CAEEL|WormBase=WBGene00000065|UniProtKB=P0DM42	Actin-3	IC	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00015	Circadian clock system	P00505	Cry	DROME|FlyBase=FBgn0025680|UniProtKB=O77059	Cryptochrome-1	IDA	10839367	PubMed	PTHR11455:SF17	CRYPTOCHROME-1
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000023202|UniProtKB=F7EU36	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00029	Huntington disease	P00805	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IDA	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05960	VAT2	MACMU|Ensembl=ENSMMUG00000014817|UniProtKB=F6VXD8	Uncharacterized protein	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00047	PDGF signaling pathway	P01140	ELK	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	ISS	10487205	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	DROME|FlyBase=FBgn0065032|UniProtKB=Q9VX82	Actin-related protein 2/3 complex subunit 3	ISS	12473693	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MOUSE|MGI=MGI=101848|UniProtKB=P62881	Guanine nucleotide-binding protein subunit beta-5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	BOVIN|Ensembl=ENSBTAG00000006495|UniProtKB=P11017	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	IC	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01275	P38	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	TAS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	CANLF|Gene=MYH9|UniProtKB=Q258K2	Myosin-9	ISS	89264452	PubMed	PTHR13140:SF317	MYOSIN-9
P00049	Parkinson disease	P01227	20S proteasome	HUMAN|HGNC=9533|UniProtKB=P25789	Proteasome subunit alpha type-4	ISS	12859888	PubMed	PTHR11599:SF13	PROTEASOME SUBUNIT ALPHA TYPE-4
P00005	Angiogenesis	P00212	EphR	HUMAN|HGNC=3393|UniProtKB=P29323	Ephrin type-B receptor 2	IGI	9990854	PubMed	PTHR24416:SF123	EPHRIN TYPE-B RECEPTOR 2
P00019	Endothelin signaling pathway	P00568	PKC	TAKRU|Ensembl=ENSTRUG00000016241|UniProtKB=H2UX35	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF305	PROTEIN KINASE C
P02757	O-antigen biosynthesis	P03048	UDP-galacto-pyranose mutase	ECOLI|EcoGene=EG11981|UniProtKB=P37747	UDP-galactopyranose mutase	ISS			PTHR21197:SF0	UDP-GALACTOPYRANOSE MUTASE
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00211	GSK3beta	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00642	MEK1-2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	MACMU|Ensembl=ENSMMUG00000018375|UniProtKB=F7H1D5	Neurogenic locus notch homolog protein 2 isoform 1 preproprotein	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00047	PDGF signaling pathway	P01142	p90RSK	HUMAN|HGNC=10439|UniProtKB=Q96S38	Ribosomal protein S6 kinase delta-1	ISS			PTHR15508:SF2	RIBOSOMAL PROTEIN S6 KINASE DELTA-1
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05923	beta-ARR2	CANLF|Ensembl=ENSCAFG00000015905|UniProtKB=E2QUH6	Uncharacterized protein	ISS	12464600	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000005147|UniProtKB=O77680	D(1A) dopamine receptor	IDA			PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00034	Integrin signalling pathway	P00944	Actin	MOUSE|MGI=MGI=2444552|UniProtKB=Q8BFZ3	Beta-actin-like protein 2	ISS	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00057	Wnt signaling pathway	P01443	Phospholipase C	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	IDA	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05731	GABA-B receptor II signaling	P05754	Ggamma	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00010	B cell activation	P00384	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00195	APC	HUMAN|HGNC=583|UniProtKB=P25054	Adenomatous polyposis coli protein	IDA	12549854	PubMed	PTHR12607:SF11	ADENOMATOUS POLYPOSIS COLI PROTEIN
P00047	PDGF signaling pathway	P01148	Grb2	ANOGA|EnsemblGenome=AGAP011768|UniProtKB=Q7PV64	AGAP011768-PA	ISS	51702266	gi	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00019	Endothelin signaling pathway	P00589	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	IGI	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00366	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	10891487	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02738	De novo purine biosynthesis	P02899	GMP synthase	HALSA|EnsemblGenome=VNG_0228G|UniProtKB=Q9HSH4	GMP synthase [glutamine-hydrolyzing] subunit A	ISS			PTHR11922:SF2	GMP SYNTHASE  GLUTAMINE-HYDROLYZING
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04569	Cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00790	beta-Tubulin	ASHGO|EnsemblGenome=AGOS_ACR225C|UniProtKB=Q75BP6	ACR225Cp	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00048	PI3 kinase pathway	P01179	PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01306	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00107	kinesin	MOUSE|MGI=MGI=1922014|UniProtKB=Q9DBS5	Kinesin light chain 4	IDA	11740561	PubMed	PTHR19959:SF139	KINESIN LIGHT CHAIN 4
P00018	EGF receptor signaling pathway	P00546	GAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	2842690	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00807	Actin	DROME|FlyBase=FBgn0000043|UniProtKB=P02572	Actin-42A	ISS	11889126	PubMed	PTHR11937:SF369	ACTIN-42A
P00019	Endothelin signaling pathway	P00590	IP3 R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05731	GABA-B receptor II signaling	P05760	AC	PANTR|Ensembl=ENSPTRG00000020589|UniProtKB=H2QWQ6	Uncharacterized protein	ISS	8163524	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	HUMAN|HGNC=1389|UniProtKB=Q00975	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	14624853	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00011	Blood coagulation	P00453	FXIII	MOUSE|MGI=MGI=88379|UniProtKB=Q07968	Coagulation factor XIII B chain	ISS	13624321	gi	PTHR19325:SF314	COAGULATION FACTOR XIII B CHAIN
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	MOUSE|MGI=MGI=2150309|UniProtKB=Q4VA61	Down syndrome cell adhesion molecule-like protein 1 homolog	ISS			PTHR44107:SF3	DOWN SYNDROME CELL ADHESION MOLECULE-LIKE PROTEIN 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	TAKRU|Ensembl=ENSTRUG00000011297|UniProtKB=H2TV18	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00006	Apoptosis signaling pathway	P00311	GCKR	MACMU|Ensembl=ENSMMUG00000020550|UniProtKB=F7D279	Mitogen-activated protein kinase kinase kinase kinase	ISS			PTHR24361:SF324	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 5
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P05913	Enkephalin release	P05978	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00037	Ionotropic glutamate receptor pathway	P01026	KA	RAT|RGD=71027|UniProtKB=P42264	Glutamate receptor ionotropic, kainate 3	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MACMU|Ensembl=ENSMMUG00000010184|UniProtKB=F6SR09	Uncharacterized protein	ISS	7476890	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	ARATH|TAIR=AT4G28710|UniProtKB=F4JM19	Myosin-14	IC			PTHR13140:SF256	MYOSIN-10-RELATED
P00024	Glycolysis	P00680	Phosphoglyceromutase	RAT|RGD=3312|UniProtKB=P25113	Phosphoglycerate mutase 1	RCA			PTHR11931:SF15	PHOSPHOGLYCERATE MUTASE 1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00056	VEGF signaling pathway	P01417	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01211	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	9298898	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05913	Enkephalin release	P05978	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	ISS	96149441	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00034	Integrin signalling pathway	P00951	Jnk	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IDA	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00627	ERK1-2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	14707121	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	CAEEL|WormBase=WBGene00002335|UniProtKB=P22981	Ras protein let-60	ISS	22022015	PubMed	PTHR24070:SF385	GTPASE HRAS
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06587	Nicotine pharmacodynamics pathway	P06614	TH	HUMAN|HGNC=11782|UniProtKB=P07101	Tyrosine 3-monooxygenase	RCA	12480184	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	RCA	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00005	Angiogenesis	P00211	GSK3beta	DROME|FlyBase=FBgn0046332|UniProtKB=P83101	Putative glycogen synthase kinase-3 homolog	ISS			PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00049	Parkinson disease	P01230	Src kinase	ORNAN|Ensembl=ENSOANG00000005501|UniProtKB=F6X6I5	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	MOUSE|MGI=MGI=1933206|UniProtKB=A2AIR5	Protein Grin3a	ISS	11554549	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IDA	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_114535|UniProtKB=C3ZHN2	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00012	Cadherin signaling pathway	P00470	F-actin	PHANO|EnsemblGenome=SNOG_01139|UniProtKB=H2KNE6	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02741	Flavin biosynthesis	P02936	FAD synthetase	RAT|RGD=1593292|UniProtKB=D4A4P4	Protein Flad1	RCA			PTHR23293:SF9	FAD SYNTHASE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00010	B cell activation	P00402	Jnk	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00240	FRS-2	HUMAN|HGNC=16970|UniProtKB=O43559	Fibroblast growth factor receptor substrate 3	ISS			PTHR21258:SF39	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=2136018|UniProtKB=Q9QYS1	Protein Wnt-16	TAS	11266476	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P00007	Axon guidance mediated by semaphorins	P00330	CRAM	PANTR|Ensembl=ENSPTRG00000011741|UniProtKB=H2R8X1	Uncharacterized protein	ISS	11034345	PubMed	PTHR11647:SF58	DIHYDROPYRIMIDINASE-RELATED PROTEIN 5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	MOUSE|MGI=MGI=894297|UniProtKB=O08585	Clathrin light chain A	ISS	9388255	PubMed	PTHR10639:SF1	CLATHRIN LIGHT CHAIN A
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00012	Cadherin signaling pathway	P00471	Cadherin	CANLF|Ensembl=ENSCAFG00000019049|UniProtKB=F6Y5X3	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF106	CADHERIN-18
P00036	Interleukin signaling pathway	P00973	PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MACMU|Ensembl=ENSMMUG00000006421|UniProtKB=F6U2K7	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IDA	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00628	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05918	p38 MAPK pathway	P06021	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12176041	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	DANRE|ZFIN=ZDB-GENE-030131-9435|UniProtKB=F1R8S3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00010	B cell activation	P00373	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IGI	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00539	14-3-3	MONDO|Ensembl=ENSMODG00000013658|UniProtKB=F6TY10	Uncharacterized protein	ISS	91108808	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P04393	Ras Pathway	P04556	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	HUMAN|HGNC=4580|UniProtKB=Q13002	Glutamate receptor ionotropic, kainate 2	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P02738	De novo purine biosynthesis	P02907	dADP kinase	NEUCR|EnsemblGenome=EFNCRG00000003892|UniProtKB=Q9UUY8	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	BOVIN|Ensembl=ENSBTAG00000021208|UniProtKB=E1BFQ8	Uncharacterized protein	ISS			PTHR23409:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 B
P00004	Alzheimer disease-presenilin pathway	P00114	actin	TAKRU|Ensembl=ENSTRUG00000014318|UniProtKB=H2UI49	Uncharacterized protein	IDA	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P02738	De novo purine biosynthesis	P02892	5-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase	PSEAE|EnsemblGenome=PA2629|UniProtKB=Q9I0K9	Adenylosuccinate lyase	ISS			PTHR43411:SF3	ADENYLOSUCCINATE LYASE
P00025	Hedgehog signaling pathway	P00692	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	IPI	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	91056091	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00036	Interleukin signaling pathway	P00990	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00017	DNA replication	P00527	Histones	DANRE|Ensembl=ENSDARG00000020504|UniProtKB=Q6PI20	Histone H3.3	ISS	12413958	PubMed	PTHR11426:SF179	HISTONE H3.3
P04393	Ras Pathway	P04570	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00009	Axon guidance mediated by netrin	P00363	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00029	Huntington disease	G01532	PolyQ HTT	MACMU|Ensembl=ENSMMUG00000008392|UniProtKB=F6VQZ3	Uncharacterized protein	ISS	7620118	PubMed	PTHR10170:SF10	HUNTINGTIN
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00046	Oxidative stress response	P01135	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	TAS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00005	Angiogenesis	P00206	Wnt	MACMU|Ensembl=ENSMMUG00000018445|UniProtKB=F7HEW6	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00056	VEGF signaling pathway	P01413	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01300	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	MACMU|Ensembl=ENSMMUG00000004596|UniProtKB=F6Q976	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF27	G PROTEIN-COUPLED RECEPTOR KINASE 5
P00005	Angiogenesis	P00189	Fzd	MACMU|Ensembl=ENSMMUG00000007486|UniProtKB=F6QL95	Frizzled-3	ISS	11212302	PubMed	PTHR11309:SF22	FRIZZLED-3
P00009	Axon guidance mediated by netrin	P00363	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	IC	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00021	FGF signaling pathway	P00631	Grb2	RAT|RGD=1306884|UniProtKB=Q4KM68	GRB2-related adaptor protein	ISS	11971956	PubMed	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	YEAST|SGD=S000003864|UniProtKB=P38627	CTP synthase 2	ISS			PTHR11550:SF0	CTP SYNTHASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MOUSE|MGI=MGI=102705|UniProtKB=P63213	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IDA	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00012	Cadherin signaling pathway	P00474	Wnt	XENTR|Ensembl=ENSXETG00000024231|UniProtKB=F6TCQ4	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00053	T cell activation	P01332	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00057	Wnt signaling pathway	P01438	PP2A	PANTR|Ensembl=ENSPTRG00000017238|UniProtKB=H2QRH7	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00054	Toll receptor signaling pathway	P01356	ERK2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00568	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IGI	2837282	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	9860142	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00048	PI3 kinase pathway	P01181	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DROME|FlyBase=FBgn0001122|UniProtKB=P16378	G protein alpha o subunit	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00640	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	CANLF|Ensembl=ENSCAFG00000010529|UniProtKB=F1PUS1	Uncharacterized protein	ISS			PTHR42884:SF8	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	EMENI|EnsemblGenome=CADANIAG00007315|UniProtKB=P20359	Actin, gamma	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02775	Salvage pyrimidine ribonucleotides	P03151	Uracil phosphoribosyl  transferase	SCHPO|PomBase=SPAC1B3.01c|UniProtKB=O13867	Uracil phosphoribosyltransferase 1	ISS			PTHR10285:SF118	URACIL PHOSPHORIBOSYLTRANSFERASE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	RAT|RGD=70487|UniProtKB=Q9WU82	Catenin beta-1	TAS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P02788	Xanthine and guanine salvage pathway	P03247	Xanthine phosphoribosyl transferase	RAT|RGD=1310177|UniProtKB=B2RYS6	Phosphoribosyl transferase domain containing 1	ISS			PTHR43340:SF5	PHOSPHORIBOSYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1
P04393	Ras Pathway	P04558	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	IDA	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00009	Axon guidance mediated by netrin	P00364	cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00019	Endothelin signaling pathway	P00566	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	RCA	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04393	Ras Pathway	P04558	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	IDA	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=1952|UniProtKB=P20309	Muscarinic acetylcholine receptor M3	IDA			PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00047	PDGF signaling pathway	P01173	STAT	MACMU|Ensembl=ENSMMUG00000010705|UniProtKB=F7G8V4	Signal transducer and activator of transcription	ISS	95188889	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00048	PI3 kinase pathway	P01188	Gbetagamma	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00049	Parkinson disease	P01212	p38 MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00006	Apoptosis signaling pathway	P00269	MAPK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	12471242	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00048	PI3 kinase pathway	P01185	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	RAT|RGD=1311060|UniProtKB=B1WC02	CTP synthase	ISS			PTHR11550:SF8	CTP SYNTHASE 1
P00048	PI3 kinase pathway	P01192	p110	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00034	Integrin signalling pathway	P00925	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000005623|UniProtKB=F7CFG8	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	IDA	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000003762|UniProtKB=A5PJS1	GNB5 protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00056	VEGF signaling pathway	P01417	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00029	Huntington disease	P00807	Actin	SCHPO|PomBase=SPBC32H8.12c|UniProtKB=P10989	Actin	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00021	FGF signaling pathway	P00633	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P04393	Ras Pathway	P04558	p38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IDA	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	CANLF|Ensembl=ENSCAFG00000012934|UniProtKB=F1P750	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	ARATH|TAIR=AT5G35630|UniProtKB=Q43127	Glutamine synthetase, chloroplastic/mitochondrial	ISS			PTHR20852:SF53	GLUTAMINE SYNTHETASE, CHLOROPLASTIC/MITOCHONDRIAL
P00036	Interleukin signaling pathway	P00987	SRF	HUMAN|HGNC=11291|UniProtKB=P11831	Serum response factor	TAS	8660892	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CANLF|Ensembl=ENSCAFG00000005662|UniProtKB=E2R907	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00046	Oxidative stress response	P01128	MEF-2	MOUSE|MGI=MGI=99532|UniProtKB=Q60929	Myocyte-specific enhancer factor 2A	TAS	11274345	PubMed	PTHR11945:SF145	MYOCYTE-SPECIFIC ENHANCER FACTOR 2A
P00057	Wnt signaling pathway	P01443	Phospholipase C	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	IDA	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02777	Succinate to proprionate conversion	P03161	Methylmalonyl-CoA mutase	MYCTU|EnsemblGenome=Rv1493|UniProtKB=P9WJK5	Probable methylmalonyl-CoA mutase large subunit	ISS			PTHR42710:SF1	METHYLMALONYL-COA MUTASE, MITOCHONDRIAL
P00059	p53 pathway	P04630	PP2A	SCHMA|EnsemblGenome=Smp_165490|UniProtKB=C1LZY9	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P02780	Thiamin metabolism	P03184	Thiamine triphosphatase	HUMAN|HGNC=18987|UniProtKB=Q9BU02	Thiamine-triphosphatase	IDA	11827967	PubMed	PTHR14586:SF1	THIAMINE-TRIPHOSPHATASE
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	ANOGA|EnsemblGenome=AGAP011133|UniProtKB=Q7QHD0	Inosine-5'-monophosphate dehydrogenase (Fragment)	ISS			PTHR11911:SF111	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=109356|UniProtKB=O09044	Synaptosomal-associated protein 23	IC	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00057	Wnt signaling pathway	P01443	Phospholipase C	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	IDA	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00034	Integrin signalling pathway	P00925	MEK	CANLF|Ensembl=ENSCAFG00000018530|UniProtKB=F1PXD3	Uncharacterized protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_116948|UniProtKB=C3YKS6	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF359	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00053	T cell activation	P01307	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DICPU|Gene=DICPUDRAFT_48914|UniProtKB=F0ZK40	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF154	ACTIN-17-RELATED
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000010521|UniProtKB=F7DQK7	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	IC	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00223	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	8170357	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=1755|UniProtKB=O75309	Cadherin-16	IDA	8120095	PubMed	PTHR24028:SF1	CADHERIN-16
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1203729|UniProtKB=Q61194	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00915	PTP-PEST	RAT|RGD=620894|UniProtKB=G3V7Q4	Protein Ptpn12	ISS	8887669	PubMed	PTHR19134:SF283	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 12
P00021	FGF signaling pathway	P00645	Rac	CAEEL|WormBase=WBGene00000424|UniProtKB=Q03206	Ras-related protein ced-10	IGI	21643963	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	CANLF|Gene=MYC|UniProtKB=Q28350	Myc proto-oncogene protein	IEP	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02742	Tetrahydrofolate biosynthesis	P02951	GTP cyclohydrolase	DROME|FlyBase=FBgn0003162|UniProtKB=P48596	GTP cyclohydrolase 1	ISS			PTHR11109:SF0	GTP CYCLOHYDROLASE 1
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	BOVIN|Ensembl=ENSBTAG00000009245|UniProtKB=Q0P594	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00586	Gq	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04393	Ras Pathway	P04547	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00034	Integrin signalling pathway	P00948	Rho	CHICK|Ensembl=ENSGALG00000001569|UniProtKB=Q9PSX7	Rho-related GTP-binding protein RhoC	ISS	14871999	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	TAS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00012	Cadherin signaling pathway	P00474	Wnt	MACMU|Ensembl=ENSMMUG00000020810|UniProtKB=F7H7P6	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF84	PROTEIN WNT-9B
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04398	p53 pathway feedback loops 2	P04665	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	BOVIN|Ensembl=ENSBTAG00000012687|UniProtKB=F1MV64	Tyrosine-protein kinase receptor	ISS	11182407	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	ANOGA|EnsemblGenome=AGAP001478|UniProtKB=Q7PXM3	AGAP001478-PA	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04547	Ras	BOVIN|Ensembl=ENSBTAG00000009778|UniProtKB=E1BMX0	Uncharacterized protein	ISS	9869449	PubMed	PTHR24070:SF186	GTPASE KRAS
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ORNAN|Ensembl=ENSOANG00000007716|UniProtKB=F6UDX9	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00047	PDGF signaling pathway	P01143	ERK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00053	T cell activation	P01336	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MACMU|Ensembl=ENSMMUG00000009778|UniProtKB=F6Y1M7	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF385	MYOSIN-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	ORNAN|Ensembl=ENSOANG00000012470|UniProtKB=F7FU89	Uncharacterized protein	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	TAS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	HUMAN|HGNC=19841|UniProtKB=Q6SJ96	TATA box-binding protein-like protein 2	ISS	600075	OMIM	PTHR10126:SF34	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 2
P00047	PDGF signaling pathway	P01143	ERK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	ISS	6466184	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	BOVIN|Ensembl=ENSBTAG00000007909|UniProtKB=F1MPE9	Uncharacterized protein	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00056	VEGF signaling pathway	P01414	PLC-gamma	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g161273|UniProtKB=A7RPJ6	Predicted protein	ISS	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00054	Toll receptor signaling pathway	P01357	MEKK1	BOVIN|Ensembl=ENSBTAG00000013790|UniProtKB=E1B847	Uncharacterized protein	ISS	12168099	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00057	Wnt signaling pathway	P01438	PP2A	HUMAN|HGNC=9313|UniProtKB=Q16537	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	IDA	10092233	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00029	Huntington disease	P00763	Hip-12	CANLF|Ensembl=ENSCAFG00000009895|UniProtKB=F1P6B8	Uncharacterized protein	ISS			PTHR16011:SF0	INTRAFLAGELLAR TRANSPORT PROTEIN 57 HOMOLOG
P00020	FAS signaling pathway	P00607	Pro-Caspase6	HUMAN|HGNC=1507|UniProtKB=P55212	Caspase-6	ISS	11463840	PubMed	PTHR10454:SF164	CASPASE-6
P00056	VEGF signaling pathway	P01425	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02747	Histidine biosynthesis	P02988	Histidinal dehydrogenase	METAC|EnsemblGenome=MA_3201|UniProtKB=Q8TL41	Histidinol dehydrogenase	ISS			PTHR21256:SF2	HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MOUSE|MGI=MGI=95822|UniProtKB=Q01098	Glutamate receptor ionotropic, NMDA 2C	ISS	11554549	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	BACSU|EnsemblGenome=BSU00180|UniProtKB=P21335	tRNA-specific adenosine deaminase	ISS			PTHR11079:SF149	TRNA-SPECIFIC ADENOSINE DEAMINASE
P00053	T cell activation	P01324	rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00057	Wnt signaling pathway	P01438	PP2A	CANLF|Ensembl=ENSCAFG00000006453|UniProtKB=F6X958	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00907	ERK	HUMAN|HGNC=6856|UniProtKB=Q9Y6R4	Mitogen-activated protein kinase kinase kinase 4	IC			PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	PANTR|Ensembl=ENSPTRG00000020930|UniProtKB=H2QX95	Uncharacterized protein	ISS	9388255	PubMed	PTHR10639:SF1	CLATHRIN LIGHT CHAIN A
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00005	Angiogenesis	P00226	Delta/Serrate	RAT|RGD=2937|UniProtKB=Q63722	Protein jagged-1	ISS	8955070	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00054	Toll receptor signaling pathway	P01354	NFkappaB	CHICK|Gene=REL|UniProtKB=P16236	Proto-oncogene c-Rel	ISS			PTHR24169:SF4	PROTO-ONCOGENE C-REL
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	RAT|RGD=2739|UniProtKB=Q00961	Glutamate receptor ionotropic, NMDA 2C	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	BOVIN|Gene=CLTC|UniProtKB=P49951	Clathrin heavy chain 1	IDA	9388255	PubMed	PTHR10292:SF7	CLATHRIN HEAVY CHAIN 1
P00006	Apoptosis signaling pathway	P00323	Bcl-xS	MOUSE|MGI=MGI=88139|UniProtKB=Q64373	Bcl-2-like protein 1	RCA			PTHR11256:SF12	BCL-2-LIKE PROTEIN 1
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05915	Opioid proenkephalin pathway	P05994	G-protein	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00024	Glycolysis	P00680	Phosphoglyceromutase	BOVIN|Gene=BPGM|UniProtKB=Q3T014	Bisphosphoglycerate mutase	ISS	2542247	PubMed	PTHR11931:SF11	BISPHOSPHOGLYCERATE MUTASE
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	ARATH|TAIR=AT5G14640|UniProtKB=Q8VZD5	Shaggy-related protein kinase epsilon	TAS			PTHR24057:SF36	SHAGGY-RELATED PROTEIN KINASE EPSILON
P05915	Opioid proenkephalin pathway	P05993	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	IC	176892	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DANRE|ZFIN=ZDB-GENE-000329-1|UniProtKB=Q7ZVI7	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01390	TFIIA complex	RAT|RGD=1308625|UniProtKB=Q641W8	General transcription factor IIA, 1-like	ISS	600519	OMIM	PTHR12694:SF9	PROTEIN STON1-GTF2A1L-RELATED
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00009	Axon guidance mediated by netrin	P00360	DCC/UNC-40	MACMU|Ensembl=ENSMMUG00000013999|UniProtKB=F6RRI0	Uncharacterized protein	ISS	12810718	PubMed	PTHR44146:SF3	NETRIN RECEPTOR DCC
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	RAT|RGD=2246|UniProtKB=Q07652	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	14507926	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	BOVIN|Ensembl=ENSBTAG00000011851|UniProtKB=A0JNB0	Tyrosine-protein kinase Fyn	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	MOUSE|MGI=MGI=1921719|UniProtKB=Q9D3R9	Transcription initiation factor TFIID subunit 7-like	ISS			PTHR12228:SF5	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 7-LIKE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CHICK|Ensembl=ENSGALG00000014539|UniProtKB=F1N861	Uncharacterized protein	ISS	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_127489|UniProtKB=C3XYC6	Putative uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00629	PP2A	HUMAN|HGNC=9302|UniProtKB=P30153	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform	ISS	11994459	PubMed	PTHR10648:SF2	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 65 KDA REGULATORY SUBUNIT A ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00260	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PANTR|Ensembl=ENSPTRG00000016745|UniProtKB=H2QQP3	Uncharacterized protein	ISS			PTHR13140:SF276	UNCONVENTIONAL MYOSIN-X
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	DANRE|ZFIN=ZDB-GENE-051202-2|UniProtKB=Q6ZM67	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF3	SUBFAMILY NOT NAMED
P06587	Nicotine pharmacodynamics pathway	P06607	EPB41	PANTR|Ensembl=ENSPTRG00000000442|UniProtKB=H2R0C4	Uncharacterized protein	ISS	12181426	PubMed	PTHR23280:SF12	PROTEIN 4.1
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	HUMAN|HGNC=12337|UniProtKB=Q9UL62	Short transient receptor potential channel 5	IDA	11055438	PubMed	PTHR10117:SF24	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 5
P00057	Wnt signaling pathway	P01449	Nemo-like Kinase	CANLF|Ensembl=ENSCAFG00000018650|UniProtKB=E2QWQ2	Serine/threonine-protein kinase NLK	ISS	10683140	PubMed	PTHR24055:SF179	SERINE/THREONINE-PROTEIN KINASE NLK
P00021	FGF signaling pathway	P00633	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00048	PI3 kinase pathway	P01179	PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00623	FGF	PANTR|Ensembl=ENSPTRG00000010159|UniProtKB=H2QES8	Fibroblast growth factor	ISS			PTHR11486:SF41	FIBROBLAST GROWTH FACTOR 22
P02759	Pyridoxal-5-phosphate biosynthesis	P03061	Pyridoxine-5-phosphate oxidase	MOUSE|MGI=MGI=2144151|UniProtKB=Q91XF0	Pyridoxine-5'-phosphate oxidase	ISS	14697241	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00021	FGF signaling pathway	P00641	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00017	DNA replication	P00527	Histones	PRIPA|Gene=PPA05646|UniProtKB=H3EZY8	Histone H3	ISS	12413958	PubMed	PTHR11426:SF169	HISTONE H3
P02787	Vitamin B6 metabolism	P03236	Pyridoxamine phosphate oxidase	YEAST|SGD=S000000239|UniProtKB=P38075	Pyridoxamine 5'-phosphate oxidase	ISS	8849441	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	MACMU|Ensembl=ENSMMUG00000005530|UniProtKB=F7GFB1	Synaptotagmin I	ISS	1840599	PubMed	PTHR10024:SF239	SYNAPTOTAGMIN-1
P00034	Integrin signalling pathway	P00913	Csk	BOVIN|Ensembl=ENSBTAG00000021424|UniProtKB=Q0VBZ0	Tyrosine-protein kinase CSK	ISS	12665526	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00034	Integrin signalling pathway	P00922	Collagen	CAEEL|WormBase=WBGene00001263|UniProtKB=P17139	Collagen alpha-1(IV) chain	IDA	10778855	PubMed	PTHR24023:SF674	COLLAGEN ALPHA-1 IV  CHAIN-RELATED
P00005	Angiogenesis	P00200	Dsh	PANTR|Gene=DVL1|UniProtKB=Q5IS48	Segment polarity protein dishevelled homolog DVL-1	ISS	12549854	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P00059	p53 pathway	P04614	Cyclin B	CANLF|Ensembl=ENSCAFG00000006595|UniProtKB=E2R3S2	Uncharacterized protein	ISS	1019642	gi	PTHR10177:SF193	G2/MITOTIC-SPECIFIC CYCLIN-B1
P02759	Pyridoxal-5-phosphate biosynthesis	P03058	Phosphohydroxythreonine aminotransferase	NEUCR|EnsemblGenome=EFNCRG00000007580|UniProtKB=Q7RWH9	Phosphoserine aminotransferase	ISS			PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P00006	Apoptosis signaling pathway	P00260	AKT	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	ISS	14526383	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00010	B cell activation	P00375	Calmodulin	CHICK|Gene_ORFName=RCJMB04_24e7|UniProtKB=P62149	Calmodulin	ISS	9753452	PubMed	PTHR23050:SF311	CALMODULIN
P00005	Angiogenesis	P00223	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	G04703	Apaf	MACMU|Ensembl=ENSMMUG00000022404|UniProtKB=F6U0K7	Apoptotic protease-activating factor 1	ISS	9267021	PubMed	PTHR22845:SF5	APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000001620|UniProtKB=F7GTE4	Uncharacterized protein	ISS			PTHR45535:SF1	MELATONIN-RELATED RECEPTOR
P04393	Ras Pathway	P04551	RalGDS	RAT|RGD=1302985|UniProtKB=Q6MGC5	Protein Rgl2	ISS	8939933	PubMed	PTHR23113:SF213	RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 2
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00053	T cell activation	P01320	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	BOVIN|Ensembl=ENSBTAG00000007882|UniProtKB=G3X7Z2	Uncharacterized protein	ISS	14507926	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00048	PI3 kinase pathway	P01187	IR	BOVIN|Ensembl=ENSBTAG00000012687|UniProtKB=F1MV64	Tyrosine-protein kinase receptor	ISS	14500580	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Ensembl=ENSPTRG00000017441|UniProtKB=H2QRU7	Glutamate receptor, ionotropic, AMPA 1	ISS	12871085	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00047	PDGF signaling pathway	P01167	Ets	BOVIN|Ensembl=ENSBTAG00000020191|UniProtKB=F1N1U5	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF203	PROTEIN FEV
P00030	Hypoxia response via HIF activation	P00819	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	TAS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00126	Fe65	PANTR|Ensembl=ENSPTRG00000033999|UniProtKB=H2RC01	Amyloid beta (A4) protein-binding, family B, member 3	ISS			PTHR14058:SF10	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 3
P00006	Apoptosis signaling pathway	P00318	PKCs	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MOUSE|MGI=MGI=109165|UniProtKB=Q61012	Guanine nucleotide-binding protein G(T) subunit gamma-T1	ISS	3100519	PubMed	PTHR13809:SF26	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT GAMMA-T1
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	IDA	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00049	Parkinson disease	P01208	Hsp70	TRIVA|Gene=TVAG_151220|UniProtKB=A2EQB9	Cytoplasmic heat shock protein 70	IDA	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	TAS	98269030	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01076	CAT	CAEEL|WormBase=WBGene00021002|UniProtKB=O16992	Uncharacterized protein	ISS			PTHR22589:SF104	SUBFAMILY NOT NAMED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04496	Mdm2	RAT|RGD=1309306|UniProtKB=Q5XIN1	Protein Mdm4	ISS			PTHR13844:SF20	PROTEIN MDM4
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00274	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	ISS	14698601	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00005	Angiogenesis	P00254	GTPase	CANAL|CGD=CAL0000192659|UniProtKB=O42825	GTP-binding protein RHO1	ISS			PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00021	FGF signaling pathway	P00627	ERK1-2	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MOUSE|MGI=MGI=95822|UniProtKB=Q01098	Glutamate receptor ionotropic, NMDA 2C	IC	14698601	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00029	Huntington disease	P00807	Actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347742|UniProtKB=E9FZ00	Cytoplasmatic actin	ISS	11889126	PubMed	PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00047	PDGF signaling pathway	P01151	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	DICDI|dictyBase=DDB_G0277825|UniProtKB=O96622	Actin-related protein 2/3 complex subunit 1	ISS	12963527	gi	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=108071|UniProtKB=P70701	Protein Wnt-10a	IDA	8717036	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	TAS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00034	Integrin signalling pathway	P00941	Integrin alpha	MACMU|Ensembl=ENSMMUG00000020448|UniProtKB=F6W6R0	Uncharacterized protein	ISS	3487386	PubMed	PTHR23220:SF23	INTEGRIN ALPHA-2
P06216	SCW signaling pathway	P06322	SCW full length	DROME|FlyBase=FBgn0005590|UniProtKB=P54631	Protein screw	IEA	http://flybase.org/reports/FBgn0005590.html	Website	PTHR11848:SF54	PROTEIN 60A-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IDA	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	MOUSE|MGI=MGI=88397|UniProtKB=Q9ERZ4	Muscarinic acetylcholine receptor M2	ISS	11166329	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00047	PDGF signaling pathway	P01160	IP3 receptor	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00046	Oxidative stress response	P01121	MKK3/6	MOUSE|MGI=MGI=1346868|UniProtKB=O09110	Dual specificity mitogen-activated protein kinase kinase 3	TAS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00018	EGF receptor signaling pathway	P00565	PKC	CANAL|CGD=CAL0003231|UniProtKB=Q5ANK2	Protein kinase C	IGI	11554554	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	IC	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00018	EGF receptor signaling pathway	P00558	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00053	T cell activation	P01332	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DANRE|ZFIN=ZDB-GENE-000329-3|UniProtKB=Q7ZVF9	Actin, cytoplasmic 2	ISS	3487386	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00010	B cell activation	P00379	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000009594|UniProtKB=G2HFH4	Somatostatin receptor type 2	ISS	12441358	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P00005	Angiogenesis	P00223	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00021	FGF signaling pathway	P00634	MEKK1-5	RAT|RGD=620966|UniProtKB=Q62925	Mitogen-activated protein kinase kinase kinase 1	IGI	11730323	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	HUMAN|HGNC=236|UniProtKB=O95622	Adenylate cyclase type 5	ISS	92317082	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IDA	1504106	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00049	Parkinson disease	P01211	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02763	Peptidoglycan biosynthesis	P03084	UDP-N-acetylmuramoylalanyl-D-glutamate 2,6-diaminopimelate ligase	LEPIN|EnsemblGenome=LA_2047|UniProtKB=Q8F4J4	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase	ISS			PTHR23135:SF4	UDP-N-ACETYLMUAMOYLALANYL-D-GLUTAMATE-2,6-DIAMINOPIMELATE LIGASE-RELATED
P04393	Ras Pathway	P04570	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	G04714	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	CANLF|Ensembl=ENSCAFG00000019633|UniProtKB=F1PDC7	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00005	Angiogenesis	P00244	MAPKAPK2/3	HUMAN|HGNC=6888|UniProtKB=Q16644	MAP kinase-activated protein kinase 3	IDA	11157753	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00558	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00004	Alzheimer disease-presenilin pathway	P00118	E-cadherin	XENTR|Xenbase=XB-GENE-482277|UniProtKB=F6QAX3	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04398	p53 pathway feedback loops 2	P04651	Ras	RAT|RGD=2981|UniProtKB=P08644	GTPase KRas	ISS	6287573	PubMed	PTHR24070:SF186	GTPASE KRAS
P00021	FGF signaling pathway	P00624	14-3-3	PANTR|Ensembl=ENSPTRG00000013529|UniProtKB=H2R8X6	Uncharacterized protein	ISS	12618428	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	TAKRU|Ensembl=ENSTRUG00000008018|UniProtKB=H2T5N4	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00927	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	RCA	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02744	Fructose galactose metabolism	P02964	Hexose 1-P uridyltransferase	PANTR|Ensembl=ENSPTRG00000020886|UniProtKB=H2QX69	Galactose-1-phosphate uridylyltransferase	ISS	1427861	PubMed	PTHR11943:SF1	GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	TAS	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04398	p53 pathway feedback loops 2	P04661	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	ISS	1171954	gi	PTHR10048:SF14	PI-3 KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00036	Interleukin signaling pathway	P00965	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	IC	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT1G10210|UniProtKB=Q39021	Mitogen-activated protein kinase 1	ISS	9836510	gi	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P02744	Fructose galactose metabolism	P02960	Galactokinase	MOUSE|MGI=MGI=95730|UniProtKB=Q9R0N0	Galactokinase	NAS	14741191	PubMed	PTHR10457:SF6	GALACTOKINASE
P00057	Wnt signaling pathway	P01451	Galpha	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	ARATH|TAIR=AT5G07880|UniProtKB=Q9SD96	SNAP25 homologous protein SNAP29	IC			PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	HUMAN|HGNC=5294|UniProtKB=P41595	5-hydroxytryptamine receptor 2B	ISS	12181435	PubMed	PTHR24247:SF31	5-HYDROXYTRYPTAMINE RECEPTOR 2B
P00019	Endothelin signaling pathway	P00586	Gq	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P02738	De novo purine biosynthesis	P02902	ADP reductase	FUSNN|EnsemblGenome=FN0103|UniProtKB=Q8RH17	Ribonucleoside-diphosphate reductase subunit beta	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CAEEL|WormBase=WBGene00004036|UniProtKB=G5EFI8	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05731	GABA-B receptor II signaling	P05760	AC	RAT|RGD=71014|UniProtKB=Q04400	Adenylate cyclase type 5	RCA	2491850	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00053	T cell activation	P01315	Calcineurin	XENTR|Xenbase=XB-GENE-952299|UniProtKB=B0BLZ8	Serine/threonine-protein phosphatase	ISS	12091710	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	HUMAN|HGNC=4394|UniProtKB=P19087	Guanine nucleotide-binding protein G(t) subunit alpha-2	ISS	12488551	PubMed	PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P04384	Gamma-aminobutyric acid synthesis	P04482	Glutamate decarboxylase	HUMAN|HGNC=18966|UniProtKB=Q9Y600	Cysteine sulfinic acid decarboxylase	ISS			PTHR11999:SF114	CYSTEINE SULFINIC ACID DECARBOXYLASE
P00048	PI3 kinase pathway	P01204	GPCR	CANLF|Gene=PTGER1|UniProtKB=Q9BGL8	Prostaglandin E2 receptor EP1 subtype	IC	14607241	PubMed	PTHR11866:SF3	PROSTAGLANDIN E2 RECEPTOR EP1 SUBTYPE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	PANTR|Ensembl=ENSPTRG00000014711|UniProtKB=H2QZF5	TGF-beta receptor type-2	ISS	9395284	PubMed	PTHR23255:SF55	TGF-BETA RECEPTOR TYPE-2
P00053	T cell activation	P01306	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00054	Toll receptor signaling pathway	P01355	AP1	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00010	B cell activation	P00381	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	XENTR|Xenbase=XB-GENE-952014|UniProtKB=Q66IG3	MGC89708 protein	ISS	11067767	PubMed	PTHR19957:SF30	SYNTAXIN-11
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=1351345|UniProtKB=P47743	Metabotropic glutamate receptor 8	IDA	12351712	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P04393	Ras Pathway	P04572	JNK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	ISS	7600581	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	PANTR|Ensembl=ENSPTRG00000003543|UniProtKB=H2Q3H4	Uncharacterized protein	RCA			PTHR22952:SF24	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 1
P04393	Ras Pathway	P04557	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	IDA	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	BOVIN|Ensembl=ENSBTAG00000013298|UniProtKB=A4IFJ5	Cytosolic phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00047	PDGF signaling pathway	P01161	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	CHICK|Gene=PSEN2|UniProtKB=Q90X07	Presenilin-2	IDA	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00005	Angiogenesis	P00183	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	7680960	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P06959	CCKR signaling map	P07221	ODC1	HUMAN|HGNC=8109|UniProtKB=P11926	Ornithine decarboxylase	RCA	9619831	PubMed	PTHR11482:SF42	ORNITHINE DECARBOXYLASE
P00036	Interleukin signaling pathway	P00972	MNK1/2	HUMAN|HGNC=7110|UniProtKB=Q9BUB5	MAP kinase-interacting serine/threonine-protein kinase 1	IC	Q9BUB5	SPACC	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00059	p53 pathway	P04633	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	RAT|RGD=3425|UniProtKB=P97887	Presenilin-1	IDA	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00021	FGF signaling pathway	P00625	MKK3,6	ORNAN|Ensembl=ENSOANG00000007732|UniProtKB=F6PXH5	Uncharacterized protein (Fragment)	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00057	Wnt signaling pathway	P01465	Ggamma	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00048	PI3 kinase pathway	P01179	PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05754	Ggamma	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	PANTR|Ensembl=ENSPTRG00000008260|UniProtKB=H2QBD7	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	ISS	12015605	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	IDA	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	RAT|RGD=61863|UniProtKB=P19493	Glutamate receptor 4	ISS	10331083	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	CANLF|Ensembl=ENSCAFG00000005204|UniProtKB=B6V8E6	Catenin beta-1	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	MACMU|Ensembl=ENSMMUG00000019999|UniProtKB=F7FNE2	Uncharacterized protein	ISS	11443533	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04552	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00020	FAS signaling pathway	P00610	MKK4	DROME|FlyBase=FBgn0024326|UniProtKB=O61444	MAP kinase kinase 4, isoform A	TAS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CHICK|Ensembl=ENSGALG00000001172|UniProtKB=P19439	Probable glutamate receptor	ISS	11319238	PubMed	PTHR18966:SF282	GLUTAMATE RECEPTOR-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CANLF|Ensembl=ENSCAFG00000016787|UniProtKB=F6V9G5	Uncharacterized protein	ISS			PTHR19957:SF97	SYNTAXIN-4
P00047	PDGF signaling pathway	P01160	IP3 receptor	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00023	General transcription regulation	P00662	TFIIA complex	HUMAN|HGNC=4647|UniProtKB=P52657	Transcription initiation factor IIA subunit 2	IGI	95241493	PubMed	PTHR10966:SF0	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MOUSE|MGI=MGI=95823|UniProtKB=Q03391	Glutamate receptor ionotropic, NMDA 2D	ISS	11554549	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MONDO|Ensembl=ENSMODG00000023429|UniProtKB=F6XI83	Uncharacterized protein	ISS			PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P00018	EGF receptor signaling pathway	P00546	GAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	2574500	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P02738	De novo purine biosynthesis	P02904	Guanylate kinase	ECOLI|EcoGene=EG10965|UniProtKB=P60546	Guanylate kinase	ISS			PTHR23117:SF13	GUANYLATE KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00059	p53 pathway	G04694	p110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00018	EGF receptor signaling pathway	P00543	ERK1-2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02746	Heme biosynthesis	P02981	Glutamate-1-semialdehyde aminotransferase	MYCTU|EnsemblGenome=Rv0524|UniProtKB=P9WMN9	Glutamate-1-semialdehyde 2,1-aminomutase	ISS			PTHR43713:SF3	GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE
P00036	Interleukin signaling pathway	P00973	PKB	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00318	PKCs	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00037	Ionotropic glutamate receptor pathway	P01015	Glu4	HUMAN|HGNC=4574|UniProtKB=P48058	Glutamate receptor 4	ISS	12941441	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00012	Cadherin signaling pathway	P00474	Wnt	PANTR|Ensembl=ENSPTRG00000004090|UniProtKB=H2Q4F7	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P02783	Tryptophan biosynthesis	P03209	Anthranilate phosphoribosyl transferase	AQUAE|EnsemblGenome=aq_209|UniProtKB=O66585	Uncharacterized protein aq_209	ISS			PTHR43285:SF2	ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE
P05912	Dopamine receptor mediated signaling pathway	P05961	DOPA decarb.	PANTR|Ensembl=ENSPTRG00000019189|UniProtKB=H2QUK8	Uncharacterized protein	ISS	90339966	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00057	Wnt signaling pathway	P01443	Phospholipase C	ANOGA|Gene=AgaP_AGAP009115|UniProtKB=Q7PW25	Phosphoinositide phospholipase C (Fragment)	ISS	12176394	PubMed	PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	RAT|RGD=2736|UniProtKB=P35439	Glutamate receptor ionotropic, NMDA 1	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00009	Axon guidance mediated by netrin	P00366	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CANLF|Ensembl=ENSCAFG00000018540|UniProtKB=F1PLG7	Uncharacterized protein	ISS			PTHR13140:SF288	UNCONVENTIONAL MYOSIN-IF
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00047	PDGF signaling pathway	P01161	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00021	FGF signaling pathway	P00627	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10875333	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01168	PI3K	ARATH|TAIR=AT1G60490|UniProtKB=P42339	Phosphatidylinositol 3-kinase VPS34	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00004	Alzheimer disease-presenilin pathway	P00111	C99	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	PANTR|Ensembl=ENSPTRG00000002956|UniProtKB=H2Q2L5	Uncharacterized protein	ISS	12063255	PubMed	PTHR24248:SF54	BETA-1 ADRENERGIC RECEPTOR
P00057	Wnt signaling pathway	P01446	Calcineurin	NEUCR|EnsemblGenome=EFNCRG00000003474|UniProtKB=Q05681	Serine/threonine-protein phosphatase 2B catalytic subunit	IDA	12015605	PubMed	PTHR11668:SF118	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED
P00057	Wnt signaling pathway	P01451	Galpha	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IC	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	RAT|RGD=1312009|UniProtKB=D4A280	Serine/threonine-protein kinase PAK 7	ISS			PTHR24361:SF183	SERINE/THREONINE-PROTEIN KINASE PAK 7
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00059	p53 pathway	G04694	p110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04397	p53 pathway by glucose deprivation	P04641	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04407	K+ channel	MOUSE|MGI=MGI=1100509|UniProtKB=O35111	Potassium channel subfamily K member 3	ISS	15282272	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00034	Integrin signalling pathway	P00909	ASAP1	PANTR|Ensembl=ENSPTRG00000013733|UniProtKB=H2QKS2	Uncharacterized protein	ISS			PTHR23180:SF35	ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1
P00046	Oxidative stress response	P01135	p38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	TAS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00572	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00019	Endothelin signaling pathway	P00570	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MOUSE|MGI=MGI=1933206|UniProtKB=A2AIR5	Protein Grin3a	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00760	Gtalpha	MACMU|Ensembl=ENSMMUG00000010339|UniProtKB=F6R9V5	Uncharacterized protein	ISS	6264430	PubMed	PTHR10218:SF67	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-1
P02757	O-antigen biosynthesis	P03045	dTDP-glucose 4,6-dehydratase	CAEEL|WormBase=WBGene00015298|UniProtKB=Q17556	Uncharacterized protein	ISS			PTHR43000:SF7	DTDP-D-GLUCOSE 4,6-DEHYDRATASE
P00029	Huntington disease	P00807	Actin	XENTR|Xenbase=XB-GENE-6469705|UniProtKB=Q6P8G3	Actin, alpha sarcomeric/skeletal	ISS	14684598	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	PHYPA|Gene=PHYPADRAFT_185037|UniProtKB=A9SHH7	Predicted protein	ISS			PTHR23050:SF245	AT16150P-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04427	5HT4 Receptor	HUMAN|HGNC=5299|UniProtKB=Q13639	5-hydroxytryptamine receptor 4	ISS	12898568	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	ISS	12488551	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	RCA	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000001962|UniProtKB=F6V2H6	Uncharacterized protein	ISS	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P02761	Pantothenate biosynthesis	P03068	Pantoate-beta-alanine ligase	BACSU|EnsemblGenome=BSU22420|UniProtKB=P52998	Pantothenate synthetase	ISS			PTHR21299:SF1	PANTOATE--BETA-ALANINE LIGASE
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05731	GABA-B receptor II signaling	P05754	Ggamma	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00023	General transcription regulation	P00658	TBP-associated factors	MACMU|Ensembl=ENSMMUG00000008569|UniProtKB=F6UPU0	Uncharacterized protein	ISS	604905	OMIM	PTHR15319:SF1	TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT C
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00045	Notch signaling pathway	P01110	Presenilin	PANTR|Ensembl=ENSPTRG00000006510|UniProtKB=H2Q8K1	Presenilin	ISS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02752	Mannose metabolism	P03017	Mannose 6-P isomerase	HUMAN|HGNC=7216|UniProtKB=P34949	Mannose-6-phosphate isomerase	NAS	20563689	gi	PTHR10309:SF0	MANNOSE-6-PHOSPHATE ISOMERASE
P00047	PDGF signaling pathway	P01154	Ras	CAEEL|WormBase=WBGene00002335|UniProtKB=P22981	Ras protein let-60	ISS	22022015	PubMed	PTHR24070:SF385	GTPASE HRAS
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05734	Synaptic vesicle trafficking	P05779	Synaptobrevin	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	RCA	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000008400|UniProtKB=H2QBL4	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF80	CADHERIN-13
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CAEEL|WormBase=WBGene00004036|UniProtKB=G5EFI8	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	MOUSE|MGI=MGI=106677|UniProtKB=Q8BRU6	Synaptic vesicular amine transporter	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00018	EGF receptor signaling pathway	P00543	ERK1-2	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	IGI	12787066	PubMed	PTHR24055:SF330	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00223	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00014	Cholesterol biosynthesis	P00493	Geranyl trans-transferase	CAEBR|Gene=CBG18688|UniProtKB=A8XTW8	Protein CBR-FDPS-1	ISS	O64905	SPACC	PTHR11525:SF0	FARNESYL PYROPHOSPHATE SYNTHASE
P00048	PI3 kinase pathway	P01199	Galpha	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS			PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00936	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00317	Fos	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P05918	p38 MAPK pathway	P06031	p38alpha	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00004	Alzheimer disease-presenilin pathway	P00174	CD44 N-terminal fragment	PANTR|Ensembl=ENSPTRG00000003501|UniProtKB=H2Q3E8	Uncharacterized protein	ISS	14871815	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00052	TGF-beta signaling pathway	P01284	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MACMU|Ensembl=ENSMMUG00000009287|UniProtKB=F7H3T9	Glutamate receptor 1 isoform 1	ISS	12871085	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	XENTR|Xenbase=XB-GENE-491938|UniProtKB=Q6DIV8	Actin, alpha 1, skeletal muscle	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00053	T cell activation	P01313	CD28	CANLF|Ensembl=ENSCAFG00000012872|UniProtKB=Q9GKP3	Costimulatory molecule B7 receptor CD28	IGI	7534617	PubMed	PTHR11494:SF7	T-CELL-SPECIFIC SURFACE GLYCOPROTEIN CD28
P00034	Integrin signalling pathway	P00948	Rho	XENTR|Xenbase=XB-GENE-941426|UniProtKB=Q28HZ4	Novel Rho protein	ISS	12024019	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00010	B cell activation	P00381	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	3449797	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DANRE|ZFIN=ZDB-GENE-050417-267|UniProtKB=F1QUN8	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF263	ACTIN
P00015	Circadian clock system	G01501	cry	ORYSJ|EnsemblGenome=OS02G0573200|UniProtKB=Q6YXC2	Cryptochrome 1a	ISS			PTHR11455:SF18	DEOXYRIBODIPYRIMIDINE PHOTO-LYASE, MITOCHONDRIAL
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00059	p53 pathway	G01574	ARF	MOUSE|MGI=MGI=104737|UniProtKB=P55271	Cyclin-dependent kinase 4 inhibitor B	RCA			PTHR24148:SF47	CYCLIN-DEPENDENT KINASE 4 INHIBITOR B-RELATED
P00047	PDGF signaling pathway	P01161	Raf	TAKRU|Ensembl=ENSTRUG00000011625|UniProtKB=H2TXG3	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	RAT|RGD=628852|UniProtKB=Q02294	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	8386525	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	PANTR|Ensembl=ENSPTRG00000014949|UniProtKB=H2QMN3	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF67	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-1
P04393	Ras Pathway	P04578	Rho	DANRE|ZFIN=ZDB-GENE-040426-1337|UniProtKB=Q7T399	Ras homolog gene family, member Ae	ISS	14871999	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MOUSE|MGI=MGI=95683|UniProtKB=P20863	Embryonic growth/differentiation factor 1	TAS	9759503	PubMed	PTHR11848:SF151	EMBRYONIC GROWTH/DIFFERENTIATION FACTOR 1
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	IDA	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00059	p53 pathway	G04694	p110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00015	Circadian clock system	P00502	Casein kinase I	MACMU|Ensembl=ENSMMUG00000010122|UniProtKB=F7HF84	Casein kinase I isoform epsilon	ISS	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TAKRU|Ensembl=ENSTRUG00000004787|UniProtKB=P53480	Actin, alpha cardiac	IC	14684598	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	RAT|RGD=2344|UniProtKB=P08485	Muscarinic acetylcholine receptor M4	ISS	12181435	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	IC	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01451	Galpha	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00047	PDGF signaling pathway	P01170	PDGF	HUMAN|HGNC=8799|UniProtKB=P04085	Platelet-derived growth factor subunit A	ISS	14504135	PubMed	PTHR11633:SF3	PLATELET-DERIVED GROWTH FACTOR SUBUNIT A
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00005	Angiogenesis	P00254	GTPase	MONDO|Ensembl=ENSMODG00000012981|UniProtKB=F7CS91	Uncharacterized protein	ISS	11360179	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	CANLF|Ensembl=ENSCAFG00000024151|UniProtKB=E2R795	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P04393	Ras Pathway	P04557	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	MONDO|Ensembl=ENSMODG00000014431|UniProtKB=F7ATX4	Clathrin heavy chain	ISS	9388255	PubMed	PTHR10292:SF7	CLATHRIN HEAVY CHAIN 1
P00034	Integrin signalling pathway	P00922	Collagen	RAT|RGD=621351|UniProtKB=P02466	Collagen alpha-2(I) chain	IDA	10778855	PubMed	PTHR24023:SF568	COLLAGEN ALPHA-2 I  CHAIN
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	HUMAN|HGNC=4595|UniProtKB=Q14832	Metabotropic glutamate receptor 3	ISS	9407094	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P02755	Methylmalonyl pathway	P03033	Propionyl-CoA carboxylase	MYCTU|EnsemblGenome=Rv2247|UniProtKB=P9WQH5	Probable propionyl-CoA carboxylase beta chain 6	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P02736	Coenzyme A biosynthesis	P02883	Pantothenoylcysteine decarboxylase	LEPIN|EnsemblGenome=LA_3936|UniProtKB=Q8EZB9	Flavoprotein	ISS			PTHR14359:SF6	PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	IDA	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MACMU|Ensembl=ENSMMUG00000002214|UniProtKB=Q28509	Beta-2 adrenergic receptor	IDA	7669252	PubMed	PTHR24248:SF21	BETA-2 ADRENERGIC RECEPTOR
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CANLF|Ensembl=ENSCAFG00000013332|UniProtKB=F1PCQ4	Uncharacterized protein	ISS	10207617	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MACMU|Ensembl=ENSMMUG00000009778|UniProtKB=F6Y1M7	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF385	MYOSIN-2
P00022	General transcription by RNA polymerase I	P00657	TBP	MOUSE|MGI=MGI=1339946|UniProtKB=P62340	TATA box-binding protein-like protein 1	ISS	10082669	PubMed	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00047	PDGF signaling pathway	P01154	Ras	DICPU|Gene=DICPUDRAFT_57324|UniProtKB=F0ZVH9	Putative uncharacterized protein rasS	ISS	94119591	PubMed	PTHR24070:SF380	RAS-LIKE PROTEIN RASS
P00060	Ubiquitin proteasome pathway	P01491	E2	ORYSJ|EnsemblGenome=OS03G0791800|UniProtKB=Q8SBC1	Os03g0791800 protein	ISS			PTHR43898:SF2	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00034	Integrin signalling pathway	P00924	Raf	MOUSE|MGI=MGI=88190|UniProtKB=P28028	Serine/threonine-protein kinase B-raf	IPI	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00034	Integrin signalling pathway	P00938	Cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00006	Apoptosis signaling pathway	P00284	Flip	MACMU|Ensembl=ENSMMUG00000012310|UniProtKB=F7DL95	CASP8 and FADD-like apoptosis regulator isoform 1	ISS	8681376	PubMed	PTHR10454:SF8	CASP8 AND FADD-LIKE APOPTOSIS REGULATOR
P00009	Axon guidance mediated by netrin	P00363	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MONDO|Ensembl=ENSMODG00000017213|UniProtKB=F6WYK8	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00049	Parkinson disease	P01230	Src kinase	XENTR|Xenbase=XB-GENE-489820|UniProtKB=F7DXH6	Tyrosine-protein kinase	ISS	8054685	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	CHICK|Ensembl=ENSGALG00000011473|UniProtKB=F1P1H2	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-478663|UniProtKB=F7EG64	Protein kinase C delta type	ISS	11880265	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MOUSE|MGI=MGI=1351338|UniProtKB=P97772	Metabotropic glutamate receptor 1	IDA	12351712	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00015	Circadian clock system	G01501	cry	PANTR|Ensembl=ENSPTRG00000003537|UniProtKB=H2Q3H0	Uncharacterized protein	ISS	11804325	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	HUMAN|HGNC=11772|UniProtKB=P36897	TGF-beta receptor type-1	TAS	10683140	PubMed	PTHR23255:SF61	TGF-BETA RECEPTOR TYPE-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00005	Angiogenesis	P00234	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8479536	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MOUSE|MGI=MGI=87904|UniProtKB=P60710	Actin, cytoplasmic 1	IC	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00056	VEGF signaling pathway	P01408	Akt/PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	XENTR|Xenbase=XB-GENE-957248|UniProtKB=Q6GLE6	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00193	SOS-1	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00623	FGF	MACMU|Ensembl=ENSMMUG00000000949|UniProtKB=F6QYV4	Fibroblast growth factor	ISS	11376006	PubMed	PTHR11486:SF17	FIBROBLAST GROWTH FACTOR 12
P00029	Huntington disease	P00806	TAFII130	ARATH|TAIR=AT1G27720|UniProtKB=Q6SJR1	Transcription initiation factor TFIID subunit 4	IDA	10973244	PubMed	PTHR15138:SF14	IP01149P-RELATED
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00233	CSL	CANLF|Ensembl=ENSCAFG00000016387|UniProtKB=E2QV83	Uncharacterized protein	ISS	12145413	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=1308760|UniProtKB=F2Z3R5	Protein Pcdhb1	ISS	8120095	PubMed	PTHR24028:SF12	PROTOCADHERIN BETA-1
P00053	T cell activation	P01305	Calmodulin	MACMU|Ensembl=ENSMMUG00000028962|UniProtKB=F7EWG5	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF322	SUBFAMILY NOT NAMED
P00053	T cell activation	P01336	Jnk	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02785	Valine biosynthesis	P03215	Branched chain amino acid aminotransferase	YEAST|SGD=S000001251|UniProtKB=P38891	Branched-chain-amino-acid aminotransferase, mitochondrial	ISS			PTHR11825:SF44	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P00029	Huntington disease	P00805	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05913	Enkephalin release	G06046	preproenkephalin mRNA	MACMU|Ensembl=ENSMMUG00000006775|UniProtKB=F7H3N8	Uncharacterized protein	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00021	FGF signaling pathway	P00638	PLCgamma	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DROME|FlyBase=FBgn0259680|UniProtKB=P83099	Putative protein kinase C delta type homolog	ISS	3755548	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00053	T cell activation	P01300	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00255	Notch	MACMU|Ensembl=ENSMMUG00000018375|UniProtKB=F7H1D5	Neurogenic locus notch homolog protein 2 isoform 1 preproprotein	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00018	EGF receptor signaling pathway	P00543	ERK1-2	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01171	PLCgamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00046	Oxidative stress response	P01135	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	TAS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P04395	Vasopressin synthesis	P04590	Vasopressin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00313	IKK	PANTR|Ensembl=ENSPTRG00000020202|UniProtKB=H2QW34	Uncharacterized protein	ISS	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MOUSE|MGI=MGI=1923959|UniProtKB=Q9CVB6	Actin-related protein 2/3 complex subunit 2	ISS	12473693	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00021	FGF signaling pathway	P00644	p38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IGI	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00010	B cell activation	P00391	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P06959	CCKR signaling map	P07117	BCL2L1	HUMAN|HGNC=992|UniProtKB=Q07817	Bcl-2-like protein 1	RCA	10611223	PubMed	PTHR11256:SF12	BCL-2-LIKE PROTEIN 1
P00048	PI3 kinase pathway	P01199	Galpha	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IC	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00896	Insulin IGF	TAKRU|Ensembl=ENSTRUG00000009557|UniProtKB=A0JGX5	Insulin-like growth factor II	ISS	4504609	gi	PTHR11454:SF10	INSULIN-LIKE GROWTH FACTOR II
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00052	TGF-beta signaling pathway	P01287	BAMBI	MACMU|Ensembl=ENSMMUG00000000567|UniProtKB=F6ZWJ7	BMP and activin membrane-bound inhibitor homolog	ISS	10519551	PubMed	PTHR15505:SF1	BMP AND ACTIVIN MEMBRANE-BOUND INHIBITOR HOMOLOG
P00057	Wnt signaling pathway	P01457	GBeta	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	IDA	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P02747	Histidine biosynthesis	P02989	Phosphoribosyl AMP cyclohydrolase	THEMA|EnsemblGenome=TM_1035|UniProtKB=Q9X0C5	Histidine biosynthesis bifunctional protein HisIE	ISS			PTHR42945:SF1	HISTIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN HISIE, CHLOROPLASTIC
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	TAKRU|Ensembl=ENSTRUG00000011944|UniProtKB=H2TZX5	Uncharacterized protein	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00011	Blood coagulation	P00430	FX	BOVIN|Ensembl=ENSBTAG00000016385|UniProtKB=P00743	Coagulation factor X	ISS	119759	gi	PTHR44064:SF3	COAGULATION FACTOR X
P00010	B cell activation	P00384	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	SCLS1|Gene=SS1G_09120|UniProtKB=A7EUW2	Glutamate dehydrogenase	ISS			PTHR43571:SF1	NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IDA	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00049	Parkinson disease	P01219	SAPK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00052	TGF-beta signaling pathway	P01284	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04376	5HT4 type receptor mediated signaling pathway	P04426	K+ channel	MONDO|Ensembl=ENSMODG00000015769|UniProtKB=F6ZSC2	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	IC	1482697	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P04397	p53 pathway by glucose deprivation	P04640	p53	CANLF|Gene=TP53|UniProtKB=Q29537	Cellular tumor antigen p53	TAS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02738	De novo purine biosynthesis	P02907	dADP kinase	DANRE|ZFIN=ZDB-GENE-000710-3|UniProtKB=Q6DI51	Nucleoside diphosphate kinase 6	ISS			PTHR11349:SF70	NUCLEOSIDE DIPHOSPHATE KINASE 6
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-478663|UniProtKB=F7EG64	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P02741	Flavin biosynthesis	P02934	Riboflavin kinase	RAT|RGD=1549748|UniProtKB=Q6AYA7	Protein Rfk	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	HUMAN|HGNC=9300|UniProtKB=P62714	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00260	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IDA	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	XENTR|Xenbase=XB-GENE-989975|UniProtKB=F6WX27	Uncharacterized protein (Fragment)	ISS	85203892	PubMed	PTHR18945:SF61	ACETYLCHOLINE RECEPTOR SUBUNIT DELTA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02731	Biotin biosynthesis	P02856	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	BACSU|EnsemblGenome=BSU09260|UniProtKB=P33189	Uncharacterized aminotransferase YhxA	ISS			PTHR42684:SF6	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00007	Axon guidance mediated by semaphorins	P00340	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00644	p38	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	4506785	gi	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DICPU|Gene=DICPUDRAFT_90232|UniProtKB=F1A175	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	MONDO|Ensembl=ENSMODG00000007421|UniProtKB=F6XBV3	Uncharacterized protein	ISS	15858232	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00013	Cell cycle	P00480	Proteasome	CANLF|Ensembl=ENSCAFG00000006455|UniProtKB=E2R5N5	Uncharacterized protein	ISS	99239941	PubMed	PTHR10539:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13
P04393	Ras Pathway	P04570	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00562	p38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00021	FGF signaling pathway	P00641	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00807	Actin	ARATH|TAIR=AT5G09810|UniProtKB=P53492	Actin-7	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	IDA	9199552	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00006	Apoptosis signaling pathway	P00310	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00206	Wnt	ANOGA|EnsemblGenome=AGAP009731|UniProtKB=Q7PM77	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF98	PROTEIN WNT-RELATED
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	TAKRU|Ensembl=ENSTRUG00000005608|UniProtKB=H2SM93	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P04375	5HT3 type receptor mediated signaling pathway	P04422	5HT3 Rec	RAT|RGD=61820|UniProtKB=Q9JJ16	5-hydroxytryptamine receptor 3B	IC	7509203	PubMed	PTHR18945:SF53	5-HYDROXYTRYPTAMINE RECEPTOR 3B
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	CAEEL|WormBase=WBGene00006390|UniProtKB=Q7YTH5	TAF (TBP-associated transcription factor) family	ISS	604903	OMIM	PTHR12321:SF78	TAF  TBP-ASSOCIATED TRANSCRIPTION FACTOR  FAMILY
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P05730	Endogenous cannabinoid signaling	P05751	Galpha	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000006307|UniProtKB=H2SSM1	Uncharacterized protein	IC			PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00057	Wnt signaling pathway	P01428	Frizzled	PANTR|Ensembl=ENSPTRG00000028511|UniProtKB=H2R570	Uncharacterized protein	ISS	12549854	PubMed	PTHR11309:SF81	FRIZZLED-1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00049	Parkinson disease	P01227	20S proteasome	MOUSE|MGI=MGI=1347014|UniProtKB=Q9R1P1	Proteasome subunit beta type-3	TAS	12859888	PubMed	PTHR11599:SF62	PROTEASOME SUBUNIT BETA TYPE-3
P00011	Blood coagulation	P00431	tPA	HUMAN|HGNC=9051|UniProtKB=P00750	Tissue-type plasminogen activator	ISS	4505861	gi	PTHR44617:SF1	TISSUE-TYPE PLASMINOGEN ACTIVATOR
P00053	T cell activation	P01322	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MACMU|Ensembl=ENSMMUG00000021180|UniProtKB=F7H6G3	Uncharacterized protein	ISS	9326641	PubMed	PTHR11848:SF78	GROWTH/DIFFERENTIATION FACTOR 15
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00057	Wnt signaling pathway	P01444	Wnt	CHICK|Ensembl=ENSGALG00000000839|UniProtKB=P49339	Protein Wnt-11	IDA	11266476	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00056	VEGF signaling pathway	P01408	Akt/PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05760	AC	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00053	T cell activation	P01307	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	G04702	p53	HUMAN|HGNC=15979|UniProtKB=Q9H3D4	Tumor protein 63	TAS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	RAT|RGD=2740|UniProtKB=Q62645	Glutamate receptor ionotropic, NMDA 2D	IC	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	IXOSC|EnsemblGenome=ISCW003614|UniProtKB=B7PHY7	Cdc42 protein, putative	ISS	15723050	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02774	Salvage pyrimidine deoxyribonucleotides	P03148	Thymidine phosphorylase	BACSU|EnsemblGenome=BSU39400|UniProtKB=P39142	Pyrimidine-nucleoside phosphorylase	ISS	10567266	PubMed	PTHR10515:SF0	THYMIDINE PHOSPHORYLASE
P04396	Vitamin D metabolism and pathway	P04607	FDX	RAT|RGD=62036|UniProtKB=P24483	Adrenodoxin, mitochondrial	IDA	2969697	PubMed	PTHR23426:SF26	ADRENODOXIN, MITOCHONDRIAL
P00048	PI3 kinase pathway	P01179	PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00757	beta-arrestin	RAT|RGD=3619|UniProtKB=P15887	S-arrestin	IDA	10206946	PubMed	PTHR11792:SF15	S-ARRESTIN
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	CANLF|Ensembl=ENSCAFG00000004930|UniProtKB=E2RFB5	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CAEBR|Gene=CBG05858|UniProtKB=A8X1H0	Protein CBR-EGL-19 (Fragment)	ISS	15737619	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P05730	Endogenous cannabinoid signaling	P05746	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CHICK|Ensembl=ENSGALG00000014539|UniProtKB=F1N861	Uncharacterized protein	ISS	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	PANTR|Ensembl=ENSPTRG00000013074|UniProtKB=H2QJP2	Uncharacterized protein	ISS	10778855	PubMed	PTHR44105:SF2	COLLAGEN ALPHA-3 VI  CHAIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00942	Fyn	MOUSE|MGI=MGI=95602|UniProtKB=P39688	Tyrosine-protein kinase Fyn	IPI	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	CAEBR|Gene=CBG02059|UniProtKB=A8WRW6	Protein CBR-UNC-2 (Fragment)	ISS	14624853	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00057	Wnt signaling pathway	P01438	PP2A	PANTR|Ensembl=ENSPTRG00000006734|UniProtKB=H2Q8X8	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MOUSE|MGI=MGI=3710243|UniProtKB=A2AQP0	Myosin-7B	ISS	10938134	PubMed	PTHR13140:SF358	MYOSIN-7B
P00057	Wnt signaling pathway	P01428	Frizzled	ANOGA|Gene=AgaP_AGAP011382|UniProtKB=Q7Q2X0	AGAP011382-PA (Fragment)	ISS	11212302	PubMed	PTHR11309:SF47	FRIZZLED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00018	EGF receptor signaling pathway	P00560	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	IC	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00029	Huntington disease	P00805	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00807	Actin	ORYSJ|EnsemblGenome=OS03G0836000|UniProtKB=Q10AZ4	Actin-3	IDA	11889126	PubMed	PTHR11937:SF254	ACTIN-1-RELATED
P00047	PDGF signaling pathway	P01159	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00018	EGF receptor signaling pathway	P00539	14-3-3	CHLRE|EnsemblGenome=CHLREDRAFT_185967|UniProtKB=A8JGV6	14-3-3 protein	IGI	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00005	Angiogenesis	P00236	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00029	Huntington disease	P00774	Dynein complex	DROME|FlyBase=FBgn0283476|UniProtKB=Q9VWZ3	Dynein heavy chain at 16F	IPI	9454836	PubMed	PTHR10676:SF339	DYNEIN HEAVY CHAIN 6, AXONEMAL
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P06664	Gonadotropin-releasing hormone receptor pathway	P06807	gnai	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	RCA	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00047	PDGF signaling pathway	P01162	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00057	Wnt signaling pathway	P01444	Wnt	BOVIN|Ensembl=ENSBTAG00000010820|UniProtKB=F1N4C0	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00005	Angiogenesis	P00243	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00576	Pre-pro ET1-4	MACMU|Ensembl=ENSMMUG00000007263|UniProtKB=F7FGG2	Preproendothelin-1	ISS	12907686	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	XENTR|Xenbase=XB-GENE-490883|UniProtKB=Q6NVA9	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00025	Hedgehog signaling pathway	P00692	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05730	Endogenous cannabinoid signaling	P05746	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IDA	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04375	5HT3 type receptor mediated signaling pathway	P04422	5HT3 Rec	RAT|RGD=61818|UniProtKB=P35563	5-hydroxytryptamine receptor 3A	ISS	7509203	PubMed	PTHR18945:SF52	5-HYDROXYTRYPTAMINE RECEPTOR 3A
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00046	Oxidative stress response	P01129	JNK1/2	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P02788	Xanthine and guanine salvage pathway	P03247	Xanthine phosphoribosyl transferase	AQUAE|EnsemblGenome=aq_544|UniProtKB=O66821	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IDA	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P06959	CCKR signaling map	P07158	NOS1	HUMAN|HGNC=7872|UniProtKB=P29475	Nitric oxide synthase, brain	RCA	10544187	PubMed	PTHR19384:SF63	NITRIC OXIDE SYNTHASE, BRAIN
P00057	Wnt signaling pathway	P01451	Galpha	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P06664	Gonadotropin-releasing hormone receptor pathway	P06847	JNK1/2	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	RCA	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00048	PI3 kinase pathway	P01199	Galpha	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00631	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	12748278	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00047	PDGF signaling pathway	P01154	Ras	BOVIN|Ensembl=ENSBTAG00000009778|UniProtKB=E1BMX0	Uncharacterized protein	ISS	9869449	PubMed	PTHR24070:SF186	GTPASE KRAS
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00048	PI3 kinase pathway	P01177	P110ACT	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01143	ERK	CHICK|Ensembl=ENSGALG00000004690|UniProtKB=Q5F3W3	Mitogen-activated protein kinase 6	ISS	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00029	Huntington disease	P00774	Dynein complex	BOVIN|Ensembl=ENSBTAG00000027134|UniProtKB=Q29RQ3	Cytoplasmic dynein 1 intermediate chain 1	ISS	9454836	PubMed	PTHR12442:SF34	CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN 1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00048	PI3 kinase pathway	P01181	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00019	Endothelin signaling pathway	P00577	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	ISS	10799299	PubMed	PTHR10048:SF14	PI-3 KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04665	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	BOVIN|Ensembl=ENSBTAG00000033153|UniProtKB=F1MG21	Uncharacterized protein	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	IDA	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=109356|UniProtKB=O09044	Synaptosomal-associated protein 23	IC	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00005	Angiogenesis	P00200	Dsh	MOUSE|MGI=MGI=94941|UniProtKB=P51141	Segment polarity protein dishevelled homolog DVL-1	ISS	12549854	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P00046	Oxidative stress response	P01126	ATF2	CHICK|Ensembl=ENSGALG00000009287|UniProtKB=O93602	Cyclic AMP-dependent transcription factor ATF-2	TAS	9819389	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P06959	CCKR signaling map	G06991	CLU	HUMAN|HGNC=2095|UniProtKB=P10909	Clusterin	RCA	21995960	PubMed	PTHR10970:SF1	CLUSTERIN
P00010	B cell activation	P00397	IKK	MOUSE|MGI=MGI=1338071|UniProtKB=O88351	Inhibitor of nuclear factor kappa-B kinase subunit beta	IGI	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P02738	De novo purine biosynthesis	P02902	ADP reductase	YEAST|SGD=S000003563|UniProtKB=P09938	Ribonucleoside-diphosphate reductase small chain 1	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CANLF|Ensembl=ENSCAFG00000005662|UniProtKB=E2R907	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MACMU|Ensembl=ENSMMUG00000015717|UniProtKB=F6SFA9	Serotonin receptor type 1B	ISS			PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P04398	p53 pathway feedback loops 2	P04662	cyclin G	BOVIN|Ensembl=ENSBTAG00000006607|UniProtKB=Q5E9I1	Cyclin-G1	ISS	7957050	PubMed	PTHR10177:SF59	CYCLIN-G1
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	ARATH|TAIR=AT5G37600|UniProtKB=Q56WN1	Glutamine synthetase cytosolic isozyme 1-1	ISS			PTHR20852:SF79	GLUTAMINE SYNTHETASE CYTOSOLIC ISOZYME 1-1-RELATED
P00025	Hedgehog signaling pathway	P00692	GSK3	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00053	T cell activation	P01315	Calcineurin	HUMAN|HGNC=9314|UniProtKB=Q08209	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	IGI	12015605	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00568	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00056	VEGF signaling pathway	P01412	HSP27	RAT|RGD=2414|UniProtKB=P23928	Alpha-crystallin B chain	ISS			PTHR11527:SF37	ALPHA-CRYSTALLIN B CHAIN
P00020	FAS signaling pathway	P00601	c-Jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05731	GABA-B receptor II signaling	P05752	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04657	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	PANTR|Ensembl=ENSPTRG00000016352|UniProtKB=H2QQ05	Uncharacterized protein	ISS	9039917	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	TRYB2|Gene=Tb09.211.4890|UniProtKB=Q38D21	Casein kinase II, putative	ISS	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00029	Huntington disease	P00807	Actin	DICDI|dictyBase=DDB_G0289487|UniProtKB=P07829	Actin-3	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P06664	Gonadotropin-releasing hormone receptor pathway	P06841	gnaq/11	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	RCA	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00011	Blood coagulation	P00413	HMWK	BOVIN|Gene=KNG1|UniProtKB=P01044	Kininogen-1	ISS	125505	gi	PTHR13814:SF12	KININOGEN-1
P00005	Angiogenesis	P00221	JNK1	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	ISS	12040174	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00052	TGF-beta signaling pathway	P01275	P38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=98954|UniProtKB=P21552	Protein Wnt-2	IDA	8717036	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P04393	Ras Pathway	P04570	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00021	FGF signaling pathway	P00627	ERK1-2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00385	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12676940	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00005	Angiogenesis	P00249	PAK	BOVIN|Ensembl=ENSBTAG00000047856|UniProtKB=G3MZE2	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00036	Interleukin signaling pathway	P00976	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IPI	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P06664	Gonadotropin-releasing hormone receptor pathway	P06787	SMAD1/5/8	MOUSE|MGI=MGI=109452|UniProtKB=P70340	Mothers against decapentaplegic homolog 1	RCA	12736218	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05974	G-Protein (i)	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00021	FGF signaling pathway	P00634	MEKK1-5	MOUSE|MGI=MGI=1346876|UniProtKB=O35099	Mitogen-activated protein kinase kinase kinase 5	ISS	12566458	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	BOVIN|Ensembl=ENSBTAG00000017139|UniProtKB=Q3ZBT5	Syntaxin-7	ISS	10321247	PubMed	PTHR19957:SF90	SYNTAXIN-7
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	HUMAN|HGNC=9509|UniProtKB=P49810	Presenilin-2	TAS	12846562	PubMed	PTHR10202:SF13	PRESENILIN-2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	LEIMA|EnsemblGenome=LmjF.18.1080|UniProtKB=Q27687	Protein kinase A catalytic subunit	IC	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	BACSU|EnsemblGenome=BSU14000|UniProtKB=P16524	Putative N-acetyl-LL-diaminopimelate aminotransferase	ISS			PTHR43795:SF24	SUBFAMILY NOT NAMED
P00016	Cytoskeletal regulation by Rho GTPase	P00521	Profilin	ORNAN|Ensembl=ENSOANG00000005189|UniProtKB=F6Q4N4	Profilin	ISS			PTHR13936:SF15	PROFILIN-2
P00021	FGF signaling pathway	P00628	JNK1-3	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00010	B cell activation	P00379	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00010	B cell activation	P00384	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IDA	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	HUMAN|HGNC=9855|UniProtKB=P62834	Ras-related protein Rap-1A	IDA	8576107	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P05731	GABA-B receptor II signaling	P05753	Ca channel	BOVIN|Ensembl=ENSBTAG00000009835|UniProtKB=F1MR37	Uncharacterized protein	ISS	14526084	PubMed	PTHR10037:SF137	VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1G
P00051	TCA cycle	P01273	Succinate Dehydrogenase	HUMAN|HGNC=10682|UniProtKB=Q99643	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	IDA	11897817	PubMed	PTHR10978:SF3	SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL
P02726	Aminobutyrate degradation	P02825	4-aminobutyrate aminotransferase	BOVIN|Gene=ABAT|UniProtKB=Q9BGI0	4-aminobutyrate aminotransferase, mitochondrial	ISS	10989446	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00029	Huntington disease	P00780	Microtubule	PANTR|Ensembl=ENSPTRG00000013680|UniProtKB=H2QKN9	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF112	TUBULIN BETA-1 CHAIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000003762|UniProtKB=A5PJS1	GNB5 protein	ISS	1499560	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	HUMAN|HGNC=1712|UniProtKB=P32320	Cytidine deaminase	ISS	12844405	PubMed	PTHR11644:SF2	CYTIDINE DEAMINASE
P06587	Nicotine pharmacodynamics pathway	P06602	PPP1CA	BRAFL|Gene=BRAFLDRAFT_219190|UniProtKB=C3Z434	Serine/threonine-protein phosphatase (Fragment)	ISS	8392016	PubMed	PTHR11668:SF402	SERINE/THREONINE-PROTEIN PHOSPHATASE
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00030	Hypoxia response via HIF activation	P00819	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12539654	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MACMU|Ensembl=ENSMMUG00000001661|UniProtKB=F7GR69	Uncharacterized protein	ISS	11554554	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	176910	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-486685|UniProtKB=F6VT32	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00018	EGF receptor signaling pathway	P00564	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	ARATH|TAIR=AT3G29380|UniProtKB=Q9LIA6	Plant-specific TFIIB-related protein 2	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	RAT|RGD=61986|UniProtKB=P97711	G protein-coupled receptor kinase 6	RCA			PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00008	Axon guidance mediated by Slit/Robo	P00355	Rho	CHICK|Ensembl=ENSGALG00000016485|UniProtKB=O93468	GTP-binding protein	ISS	11973360	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CAEEL|WormBase=WBGene00003774|UniProtKB=G5EGQ9	NMDA class glutamate Receptor	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00034	Integrin signalling pathway	P00931	Integrin beta	PANTR|Ensembl=ENSPTRG00000015313|UniProtKB=H2R828	Integrin beta	ISS	3487386	PubMed	PTHR10082:SF26	INTEGRIN BETA-5
P02731	Biotin biosynthesis	P02858	8-Amino-7-oxononanoate synthase	ECOLI|EcoGene=EG10121|UniProtKB=P12998	8-amino-7-oxononanoate synthase	ISS			PTHR13693:SF77	8-AMINO-7-OXONONANOATE SYNTHASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00053	T cell activation	P01332	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00009	Axon guidance mediated by netrin	P00364	cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00059	p53 pathway	P01486	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02747	Histidine biosynthesis	P02985	Histidinol dehydrogenase	GLOVI|EnsemblGenome=BAC89265|UniProtKB=Q7NL02	Histidinol dehydrogenase	ISS			PTHR21256:SF2	HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	BOVIN|Gene=SLC18A2|UniProtKB=Q27963	Synaptic vesicular amine transporter	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00034	Integrin signalling pathway	P00930	Dock180	MOUSE|MGI=MGI=2429765|UniProtKB=Q8BUR4	Dedicator of cytokinesis protein 1	RCA			PTHR23317:SF79	DEDICATOR OF CYTOKINESIS PROTEIN 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014262|UniProtKB=F7BYS8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00059	p53 pathway	P01481	ATM/ATR	YEAST|SGD=S000000340|UniProtKB=P38111	Serine/threonine-protein kinase MEC1	ISS			PTHR11139:SF69	SERINE/THREONINE-PROTEIN KINASE ATR
P04376	5HT4 type receptor mediated signaling pathway	P04431	5HT transporter	MOUSE|MGI=MGI=96285|UniProtKB=Q60857	Sodium-dependent serotonin transporter	ISS	7681602	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P00057	Wnt signaling pathway	P01435	SWI/SNF	CAEEL|WormBase=WBGene00022182|UniProtKB=Q9BL39	SWI/SNF nucleosome remodeling complex component	ISS	11532957	PubMed	PTHR13711:SF206	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY E MEMBER 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IC	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00021	FGF signaling pathway	P00642	MEK1-2	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05730	Endogenous cannabinoid signaling	P05751	Galpha	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IC	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	TRIAD|EnsemblGenome=TriadG63686|UniProtKB=B3RQ31	Beta-tubulin	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00054	Toll receptor signaling pathway	P01355	AP1	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00034	Integrin signalling pathway	P00924	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01443	Phospholipase C	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00006	Apoptosis signaling pathway	P00305	Caspase 3	HUMAN|HGNC=1504|UniProtKB=P42574	Caspase-3	IDA	7983002	PubMed	PTHR10454:SF198	CASPASE-3
P02778	Sulfate assimilation	P03167	Sulfate adenylyltransferase	PANTR|Ensembl=ENSPTRG00000016347|UniProtKB=H2QQ02	Uncharacterized protein	ISS			PTHR11055:SF17	BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MOUSE|MGI=MGI=95819|UniProtKB=P35438	Glutamate receptor ionotropic, NMDA 1	IC	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00016	Cytoskeletal regulation by Rho GTPase	P00507	Rho	SCHPO|PomBase=SPAC1F7.04|UniProtKB=Q09914	GTP-binding protein rho1	ISS	11973360	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	MOUSE|MGI=MGI=109284|UniProtKB=Q61144	Presenilin-2	IDA	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	IDA	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P05913	Enkephalin release	P05975	GPCR (s)	MONDO|Ensembl=ENSMODG00000008382|UniProtKB=F7CDR6	Uncharacterized protein (Fragment)	ISS	11259487	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00029	Huntington disease	P00796	Kainate receptor	HUMAN|HGNC=4579|UniProtKB=P39086	Glutamate receptor ionotropic, kainate 1	IDA	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00010	B cell activation	P00373	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	RAT|RGD=1309504|UniProtKB=D3ZRN3	Protein Actbl2	ISS	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00021	FGF signaling pathway	P00646	RasGAP	ORNAN|Ensembl=ENSOANG00000014753|UniProtKB=F7EPN2	Uncharacterized protein (Fragment)	ISS	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05913	Enkephalin release	P05978	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01428	Frizzled	ORNAN|Ensembl=ENSOANG00000004982|UniProtKB=F7DIA9	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF34	FRIZZLED-2
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00227	PLA2	MONDO|Ensembl=ENSMODG00000011791|UniProtKB=F7CBU9	Phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00048	PI3 kinase pathway	P01193	IRS	RAT|RGD=2922|UniProtKB=P35570	Insulin receptor substrate 1	IGI	5031805	gi	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00021	FGF signaling pathway	P00644	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01065	VAChT	ANOGA|EnsemblGenome=AGAP002369|UniProtKB=Q7PR83	AGAP002369-PA	ISS	21863848	PubMed	PTHR23506:SF13	VESICULAR ACETYLCHOLINE TRANSPORTER
P04393	Ras Pathway	P04558	p38	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	IDA	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P06211	BMP/activin signaling pathway-drosophila	P06255	TGFbetaR II	DROME|FlyBase=FBgn0024179|UniProtKB=M9PE88	Receptor protein serine/threonine kinase	RCA	11856529	PubMed	PTHR23255:SF52	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	BOVIN|Ensembl=ENSBTAG00000014674|UniProtKB=P41985	Muscarinic acetylcholine receptor M2	ISS	11166329	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00057	Wnt signaling pathway	P01451	Galpha	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04398	p53 pathway feedback loops 2	P04665	AKT	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00019	Endothelin signaling pathway	P00587	Raf-1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IGI	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	NEUCR|EnsemblGenome=EFNCRG00000003893|UniProtKB=P78711	Actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000013084|UniProtKB=F7H390	Uncharacterized protein	ISS	12441358	PubMed	PTHR24247:SF108	5-HYDROXYTRYPTAMINE RECEPTOR 5A
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00054	Toll receptor signaling pathway	P01346	TLR	MACMU|Ensembl=ENSMMUG00000014255|UniProtKB=F7C3S7	Uncharacterized protein	ISS			PTHR44312:SF2	TOLL-LIKE RECEPTOR 8
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00029	Huntington disease	P00774	Dynein complex	ANOGA|EnsemblGenome=AGAP009568|UniProtKB=Q7Q1Z0	AGAP009568-PA (Fragment)	IPI	9454836	PubMed	PTHR10676:SF354	DYNEIN HEAVY CHAIN AT 36C
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	MACMU|Ensembl=ENSMMUG00000010184|UniProtKB=F6SR09	Uncharacterized protein	ISS	8314195	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00019	Endothelin signaling pathway	P00589	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	DANRE|ZFIN=ZDB-GENE-040704-15|UniProtKB=Q6GMG5	Inosine-5'-monophosphate dehydrogenase 1a	ISS			PTHR11911:SF74	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	RAT|RGD=621060|UniProtKB=O88777	Presenilin-2	TAS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00047	PDGF signaling pathway	P01162	MEK	DROME|FlyBase=FBgn0010269|UniProtKB=Q24324	Dual specificity mitogen-activated protein kinase kinase dSOR1	ISS	176872	OMIM	PTHR24361:SF629	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1
P00018	EGF receptor signaling pathway	P00539	14-3-3	RAT|RGD=61998|UniProtKB=P35213	14-3-3 protein beta/alpha	ISS	91108808	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00018	EGF receptor signaling pathway	P00562	p38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	IGI	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00024	Glycolysis	P00679	Aldolase	PANTR|Gene=ALDOA|UniProtKB=A5A6I5	Fructose-bisphosphate aldolase A	ISS	6086339	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00012	Cadherin signaling pathway	P00467	alpha-catenin	MACMU|Ensembl=ENSMMUG00000017985|UniProtKB=F7DN31	Uncharacterized protein	ISS	1768802	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00019	Endothelin signaling pathway	P00566	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01320	PLC-gamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00034	Integrin signalling pathway	P00949	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	7680960	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	MOUSE|MGI=MGI=109482|UniProtKB=P97445	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	15699344	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00053	T cell activation	P01332	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MONDO|Ensembl=ENSMODG00000014736|UniProtKB=F6ZC55	Phosphoinositide phospholipase C	ISS			PTHR10336:SF84	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2
P00056	VEGF signaling pathway	P01412	HSP27	PANTR|Ensembl=ENSPTRG00000013953|UniProtKB=H2QL35	Uncharacterized protein	ISS			PTHR11527:SF36	ALPHA-CRYSTALLIN A CHAIN
P00052	TGF-beta signaling pathway	P01292	RSmads	CAEBR|Gene=CBG02231|UniProtKB=A8WS81	Dwarfin sma	ISS			PTHR13703:SF44	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG
P06664	Gonadotropin-releasing hormone receptor pathway	P06802	IR	MOUSE|MGI=MGI=96575|UniProtKB=P15208	Insulin receptor	RCA	2983222	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P05731	GABA-B receptor II signaling	P05754	Ggamma	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00019	Endothelin signaling pathway	P00590	IP3 R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00018	EGF receptor signaling pathway	P00564	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12676940	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00010	B cell activation	P00371	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00807	Actin	MACMU|Ensembl=ENSMMUG00000017683|UniProtKB=F6UA63	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00029	Huntington disease	P00780	Microtubule	BOVIN|Ensembl=ENSBTAG00000021013|UniProtKB=Q3ZBU7	Tubulin beta-4A chain	ISS	12932731	PubMed	PTHR11588:SF253	TUBULIN BETA-4A CHAIN
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	MOUSE|MGI=MGI=109284|UniProtKB=Q61144	Presenilin-2	TAS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	PANTR|Ensembl=ENSPTRG00000006510|UniProtKB=H2Q8K1	Presenilin	ISS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00048	PI3 kinase pathway	P01187	IR	CANLF|Ensembl=ENSCAFG00000018170|UniProtKB=E2RPM8	Tyrosine-protein kinase receptor	ISS	11182407	gi	PTHR24416:SF402	INSULIN RECEPTOR
P05915	Opioid proenkephalin pathway	P05994	G-protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IDA	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00021	FGF signaling pathway	P00644	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	CHICK|Ensembl=ENSGALG00000027629|UniProtKB=Q5ZJ03	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00057	Wnt signaling pathway	P01444	Wnt	RAT|RGD=1307015|UniProtKB=D3ZRW5	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P04398	p53 pathway feedback loops 2	P04665	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00017	DNA replication	P00535	5' to 3' Exoribonulcease	MOUSE|MGI=MGI=894687|UniProtKB=Q9DBR1	5'-3' exoribonuclease 2	ISS	99339991	PubMed	PTHR12341:SF41	5'-3' EXORIBONUCLEASE 2
P00034	Integrin signalling pathway	P00931	Integrin beta	MACMU|Ensembl=ENSMMUG00000003289|UniProtKB=F7FG54	Integrin beta	ISS	5805339	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	CANLF|Ensembl=ENSCAFG00000007782|UniProtKB=F1PWZ2	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF358	MYOSIN-7B
P05913	Enkephalin release	P05977	G-Protein (s)	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00029	Huntington disease	P00790	beta-Tubulin	TAKRU|Ensembl=ENSTRUG00000005300|UniProtKB=H2SJZ5	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00907	ERK	MACMU|Ensembl=ENSMMUG00000008503|UniProtKB=F6TGJ6	Uncharacterized protein	ISS	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P02751	Lysine biosynthesis	P03006	Dihydrodipicolinate  reductase	THEMA|EnsemblGenome=TM_1520|UniProtKB=Q9X1K8	4-hydroxy-tetrahydrodipicolinate reductase	ISS			PTHR20836:SF0	DIHYDRODIPICOLINATE REDUCTASE-LIKE PROTEIN CRR1, CHLOROPLASTIC
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	MONDO|Ensembl=ENSMODG00000023683|UniProtKB=F6T0L6	Uncharacterized protein (Fragment)	ISS	11861492	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P06664	Gonadotropin-releasing hormone receptor pathway	P06757	JUN	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	RCA	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	BOVIN|Ensembl=ENSBTAG00000040439|UniProtKB=F6Q2H9	Uncharacterized protein	ISS			PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00023	General transcription regulation	P00660	RNA Polymerase II	PANTR|Ensembl=ENSPTRG00000014356|UniProtKB=H2QLN0	Polymerase (RNA) II (DNA directed) polypeptide F	ISS	415387	gi	PTHR10773:SF12	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00385	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00010	B cell activation	P00381	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01168	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_126324|UniProtKB=C3XYC2	Putative uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P06664	Gonadotropin-releasing hormone receptor pathway	P06731	Prx2	MOUSE|MGI=MGI=98218|UniProtKB=Q06348	Paired mesoderm homeobox protein 2	RCA			PTHR24329:SF347	PAIRED MESODERM HOMEOBOX PROTEIN 2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05915	Opioid proenkephalin pathway	P05987	peptide F	BOVIN|Ensembl=ENSBTAG00000004924|UniProtKB=P01211	Proenkephalin-A	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MONDO|Ensembl=ENSMODG00000018204|UniProtKB=F6PGX6	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	89107990	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IDA	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00013	Cell cycle	P00480	Proteasome	PANTR|Ensembl=ENSPTRG00000008343|UniProtKB=H2QBI1	Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 7	ISS	95275316	PubMed	PTHR10540:SF7	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7
P02779	Thiamin biosynthesis	P03170	Hydroxymethylpyrimidine phosphate kinase	SCHPO|PomBase=SPCC18B5.05c|UniProtKB=Q9USL6	Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase C18B5.05c	ISS			PTHR20858:SF17	HYDROXYMETHYLPYRIMIDINE/PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	PANTR|Ensembl=ENSPTRG00000018398|UniProtKB=H2QTD1	Glycoprotein hormones alpha chain	ISS	1099091	PubMed	PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P04398	p53 pathway feedback loops 2	P04665	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	G04714	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00034	Integrin signalling pathway	P00944	Actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	ISS	3487386	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00056	VEGF signaling pathway	P01407	Erk	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05731	GABA-B receptor II signaling	P05753	Ca channel	BOVIN|Ensembl=ENSBTAG00000007882|UniProtKB=G3X7Z2	Uncharacterized protein	ISS	15079861	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MOUSE|MGI=MGI=2150393|UniProtKB=Q91ZU9	Glutamate receptor ionotropic, NMDA 3B	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	ARATH|TAIR=AT1G61290|UniProtKB=O64791	Syntaxin-124	IC			PTHR19957:SF80	SYNTAXIN-124-RELATED
P00034	Integrin signalling pathway	P00941	Integrin alpha	RAT|RGD=71075|UniProtKB=Q9QYE7	Integrin alpha-D	IPI	3487386	PubMed	PTHR23220:SF19	INTEGRIN ALPHA-D
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ORNAN|Ensembl=ENSOANG00000007716|UniProtKB=F6UDX9	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05731	GABA-B receptor II signaling	P05752	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	RCA	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00029	Huntington disease	P00796	Kainate receptor	RAT|RGD=2733|UniProtKB=P42260	Glutamate receptor ionotropic, kainate 2	IDA	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00005	Angiogenesis	P00205	GAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	ISS	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	IDA	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	HUMAN|HGNC=4597|UniProtKB=P41594	Metabotropic glutamate receptor 5	ISS	14614461	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONBE|Gene=37852|UniProtKB=A9V489	Predicted protein	IC	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	P01451	Galpha	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00311	GCKR	RAT|RGD=621280|UniProtKB=Q924I2	Mitogen-activated protein kinase kinase kinase kinase 3	ISS			PTHR24361:SF205	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 3
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	MACMU|Ensembl=ENSMMUG00000010173|UniProtKB=F7AGU8	Presenilin	ISS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=2321|UniProtKB=Q63315	Cadherin-22	IDA	8120095	PubMed	PTHR24027:SF311	CADHERIN-22
P00018	EGF receptor signaling pathway	P00543	ERK1-2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00053	T cell activation	P01319	PAK	MOUSE|MGI=MGI=1339656|UniProtKB=Q61036	Serine/threonine-protein kinase PAK 3	ISS	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	HALSA|EnsemblGenome=VNG_1644G|UniProtKB=Q9HPG8	Ribonucleoside reductase large chain	ISS			PTHR43371:SF1	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01154	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000018989|UniProtKB=A5D7D8	GRM3 protein	ISS	12351712	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00021	FGF signaling pathway	P00644	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00056	VEGF signaling pathway	P01425	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00561	STAT	HUMAN|HGNC=11362|UniProtKB=P42224	Signal transducer and activator of transcription 1-alpha/beta	IGI	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00053	T cell activation	P01320	PLC-gamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P06959	CCKR signaling map	P07228	MAPK1/3	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	RCA	9230117	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P02775	Salvage pyrimidine ribonucleotides	P03150	Uridine kinase	RAT|RGD=1308313|UniProtKB=B5DF24	Uridine-cytidine kinase	ISS			PTHR10285:SF66	URIDINE-CYTIDINE KINASE 1
P04393	Ras Pathway	P04569	Cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	MONDO|Ensembl=ENSMODG00000018237|UniProtKB=F6PG65	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00021	FGF signaling pathway	P00642	MEK1-2	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	2837282	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00047	PDGF signaling pathway	P01142	p90RSK	MONDO|Ensembl=ENSMODG00000008086|UniProtKB=F6YJ34	Ribosomal protein S6 kinase	ISS	2779569	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00020	FAS signaling pathway	P00615	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	XENTR|Xenbase=XB-GENE-976753|UniProtKB=Q0VFR6	Syntaxin 1A (Brain)	ISS	1321498	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00018	EGF receptor signaling pathway	P00562	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00052	TGF-beta signaling pathway	P01284	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00641	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00057	Wnt signaling pathway	P01451	Galpha	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	IDA	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00029	Huntington disease	P00790	beta-Tubulin	CHICK|Ensembl=ENSGALG00000000059|UniProtKB=F1NMU4	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00053	T cell activation	P01332	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01089	VAChT	RAT|RGD=62072|UniProtKB=Q62666	Vesicular acetylcholine transporter	IC			PTHR23506:SF13	VESICULAR ACETYLCHOLINE TRANSPORTER
P00019	Endothelin signaling pathway	P00566	ERK	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05913	Enkephalin release	P05972	PKA	DICDI|dictyBase=DDB_G0283907|UniProtKB=P34099	cAMP-dependent protein kinase catalytic subunit	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00005	Angiogenesis	P00243	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01230	Src kinase	BOVIN|Ensembl=ENSBTAG00000008938|UniProtKB=E1BIM8	Tyrosine-protein kinase	ISS	8054685	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00034	Integrin signalling pathway	P00907	ERK	CANLF|Ensembl=ENSCAFG00000015640|UniProtKB=E2QVF3	Uncharacterized protein	ISS	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00053	T cell activation	P01307	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00049	Parkinson disease	P01227	20S proteasome	SCHPO|PomBase=SPAC23D3.07|UniProtKB=Q09841	Probable proteasome subunit beta type-2	TAS	12859888	PubMed	PTHR11599:SF44	AT05866P-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01457	GBeta	BRAFL|Gene=BRAFLDRAFT_220697|UniProtKB=C3ZSF0	Putative uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	HUMAN|HGNC=6267|UniProtKB=P48051	G protein-activated inward rectifier potassium channel 2	ISS	12374786	PubMed	PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P00004	Alzheimer disease-presenilin pathway	P00111	C99	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	10669416	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DICDI|dictyBase=DDB_G0279413|UniProtKB=P05987	cAMP-dependent protein kinase regulatory subunit	IC	2372396	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	HUMAN|HGNC=30290|UniProtKB=Q9NZQ0	DnaJ homolog subfamily C member 27	IDA			PTHR24073:SF269	DNAJ HOMOLOG SUBFAMILY C MEMBER 27
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	IDA	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00047	PDGF signaling pathway	P01143	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	11204774	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04393	Ras Pathway	P04567	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CHICK|Ensembl=ENSGALG00000011248|UniProtKB=F1P354	Phosphoinositide phospholipase C	ISS			PTHR10336:SF84	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2
P00048	PI3 kinase pathway	P01177	P110ACT	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	IGI	14526383	PubMed	PTHR10048:SF14	PI-3 KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06834	MAP3Ks	MOUSE|MGI=MGI=1346880|UniProtKB=Q80XI6	Mitogen-activated protein kinase kinase kinase 11	RCA			PTHR43997:SF1	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	HUMAN|HGNC=10634|UniProtKB=P80098	C-C motif chemokine 7	ISS			PTHR12015:SF78	C-C MOTIF CHEMOKINE 7
P04397	p53 pathway by glucose deprivation	P04641	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01472	Histone deacetylase	HUMAN|HGNC=13315|UniProtKB=Q9BY41	Histone deacetylase 8	IDA	10485845	PubMed	PTHR10625:SF142	HISTONE DEACETYLASE 8
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	HUMAN|HGNC=17175|UniProtKB=Q9P212	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	10934033	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	CHICK|Gene=RGS20|UniProtKB=Q9PWA1	Regulator of G-protein signaling 20	IDA	8756726	PubMed	PTHR10845:SF175	REGULATOR OF G-PROTEIN SIGNALING 20
P00012	Cadherin signaling pathway	P00462	Casein kinase II	MONDO|Ensembl=ENSMODG00000019523|UniProtKB=F6VCI6	Uncharacterized protein	ISS	10806215	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00030	Hypoxia response via HIF activation	P00819	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04384	Gamma-aminobutyric acid synthesis	P04480	GABA aminotransferase	CANLF|Ensembl=ENSCAFG00000019030|UniProtKB=E2R776	Uncharacterized protein	ISS	8133261	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9407|UniProtKB=Q15139	Serine/threonine-protein kinase D1	ISS	12393506	PubMed	PTHR22968:SF9	SERINE/THREONINE-PROTEIN KINASE D1
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	YEAST|SGD=S000005314|UniProtKB=P53599	MAP kinase kinase kinase SSK2	ISS			PTHR24361:SF36	SERINE/THREONINE-PROTEIN KINASE NEK4
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ARATH|TAIR=AT2G42090|UniProtKB=P93738	Putative actin-9	IDA	11889126	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00645	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12912997	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	DICDI|dictyBase=DDB_G0277143|UniProtKB=P36408	Guanine nucleotide-binding protein subunit beta	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	RAT|RGD=2346|UniProtKB=P09483	Neuronal acetylcholine receptor subunit alpha-4	IC	85270494	PubMed	PTHR18945:SF401	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4
P00059	p53 pathway	P04619	HMG1	RAT|RGD=1563668|UniProtKB=D3ZC69	Protein RGD1563668	ISS			PTHR13711:SF164	HIGH MOBILITY GROUP PROTEIN B1-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06762	EIF2A	MOUSE|MGI=MGI=1098684|UniProtKB=Q8BJW6	Eukaryotic translation initiation factor 2A	RCA			PTHR13227:SF0	EUKARYOTIC TRANSLATION INITIATION FACTOR 2A
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00558	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00019	Endothelin signaling pathway	P00577	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	RAT|RGD=71034|UniProtKB=P32305	5-hydroxytryptamine receptor 7	IDA	12441358	PubMed	PTHR24247:SF116	5-HYDROXYTRYPTAMINE RECEPTOR 7
P05915	Opioid proenkephalin pathway	P05992	met-Enkephalin	MOUSE|MGI=MGI=104629|UniProtKB=P22005	Proenkephalin-A	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	TAKRU|Ensembl=ENSTRUG00000015413|UniProtKB=H2UR30	Uncharacterized protein	ISS			PTHR11681:SF13	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	PANTR|Ensembl=ENSPTRG00000004519|UniProtKB=H2Q569	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00047	PDGF signaling pathway	P01151	PKB	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	20855874	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00022	General transcription by RNA polymerase I	P00652	RNA Polymerase I  Complex	BOVIN|Ensembl=ENSBTAG00000008642|UniProtKB=Q1RMG8	DNA-directed RNA polymerases I and III subunit RPAC2	ISS	12446911	PubMed	PTHR13946:SF28	DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2
P04398	p53 pathway feedback loops 2	P04651	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00010	B cell activation	P00383	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02752	Mannose metabolism	P03018	Mannose 1-P guanylyl transferase	PYRAE|EnsemblGenome=PAE3554|UniProtKB=Q8ZSW5	Mannose-1-phosphate guanyltransferase	IEA	11792869	PubMed	PTHR22572:SF126	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00005	Angiogenesis	P00182	p38MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	DROME|FlyBase=FBgn0003205|UniProtKB=P08646	Ras-like protein 1	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P05918	p38 MAPK pathway	P06031	p38alpha	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	DANRE|ZFIN=ZDB-GENE-041114-26|UniProtKB=F1RE11	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04393	Ras Pathway	P04556	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P05917	Opioid proopiomelanocortin pathway	P06011	AC	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00048	PI3 kinase pathway	P01179	PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00219	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IC	10395542	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00047	PDGF signaling pathway	P01160	IP3 receptor	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00037	Ionotropic glutamate receptor pathway	P01015	Glu4	DANRE|ZFIN=ZDB-GENE-030131-8013|UniProtKB=F1QBT6	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00036	Interleukin signaling pathway	P00975	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00005	Angiogenesis	P00249	PAK	MACMU|Ensembl=ENSMMUG00000012033|UniProtKB=F7GWI2	Serine/threonine-protein kinase PAK 2	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ARATH|TAIR=AT4G34460|UniProtKB=P49177	Guanine nucleotide-binding protein subunit beta	IC	9754712	PubMed	PTHR19850:SF48	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA
P00012	Cadherin signaling pathway	P00475	Frizzled	CHICK|Gene=FZD10|UniProtKB=Q9PWH2	Frizzled-10	IDA	11212302	PubMed	PTHR11309:SF86	FRIZZLED-10
P00047	PDGF signaling pathway	P01161	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00629	PP2A	TAKRU|Ensembl=ENSTRUG00000003840|UniProtKB=H2S9H8	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MACMU|Ensembl=ENSMMUG00000016675|UniProtKB=F6VTB5	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00034	Integrin signalling pathway	P00948	Rho	TRIAD|EnsemblGenome=TriadG20369|UniProtKB=B3RIM6	Putative uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00004	Alzheimer disease-presenilin pathway	P00178	BACE-1 pro-domain	MACMU|Ensembl=ENSMMUG00000007785|UniProtKB=F7CQI1	Beta-secretase 1 isoform A preproprotein	ISS	10531052	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00021	FGF signaling pathway	P00634	MEKK1-5	HUMAN|HGNC=6857|UniProtKB=Q99683	Mitogen-activated protein kinase kinase kinase 5	IGI	12968034	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00057	Wnt signaling pathway	P01444	Wnt	RAT|RGD=1597195|UniProtKB=D4A9J2	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00057	Wnt signaling pathway	P01471	alpha-catenin	RAT|RGD=1359485|UniProtKB=Q5U302	Catenin (Cadherin associated protein), alpha 1	ISS	1768802	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00052	TGF-beta signaling pathway	P01284	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01164	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	11256888	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04393	Ras Pathway	P04541	p90RSK	CHICK|Ensembl=ENSGALG00000016406|UniProtKB=F1NLJ3	Uncharacterized protein	ISS	10558991	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	CANLF|Ensembl=ENSCAFG00000006453|UniProtKB=F6X958	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P06664	Gonadotropin-releasing hormone receptor pathway	P06769	Gbeta	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	RCA	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	RCA	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00084	X11alpha	PANTR|Ensembl=ENSPTRG00000021007|UniProtKB=H2QXC2	Uncharacterized protein	ISS	9614075	PubMed	PTHR12345:SF14	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 1
P00049	Parkinson disease	P01227	20S proteasome	ANOGA|EnsemblGenome=AGAP001697|UniProtKB=Q7PY13	Proteasome subunit beta type	TAS	12859888	PubMed	PTHR11599:SF62	PROTEASOME SUBUNIT BETA TYPE-3
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00021	FGF signaling pathway	P00646	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	20908895	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00036	Interleukin signaling pathway	P00990	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	LEIMA|EnsemblGenome=LmjF.18.1080|UniProtKB=Q27687	Protein kinase A catalytic subunit	IC	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00053	T cell activation	P01332	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MOUSE|MGI=MGI=1858964|UniProtKB=P61164	Alpha-centractin	IC	14684598	PubMed	PTHR11937:SF46	ALPHA-CENTRACTIN
P00053	T cell activation	P01312	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-040718-93|UniProtKB=Q6DGZ5	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	MOUSE|MGI=MGI=95816|UniProtKB=B1AS29	Glutamate receptor ionotropic, kainate 3	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P04396	Vitamin D metabolism and pathway	G04688	24-Hydroxylase	MACMU|Ensembl=ENSMMUG00000014860|UniProtKB=F6U4F6	Uncharacterized protein	ISS	11686044	PubMed	PTHR24291:SF5	1,25-DIHYDROXYVITAMIN D 3  24-HYDROXYLASE, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00848	Grb	RAT|RGD=1306884|UniProtKB=Q4KM68	GRB2-related adaptor protein	ISS	51702266	gi	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00046	Oxidative stress response	P01135	p38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	MOUSE|MGI=MGI=94926|UniProtKB=P51436	D(4) dopamine receptor	ISS	11861492	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00006	Apoptosis signaling pathway	P00282	IGFR2	PANTR|Ensembl=ENSPTRG00000018764|UniProtKB=H2QU01	Uncharacterized protein	ISS	6382022	PubMed	PTHR15071:SF17	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00036	Interleukin signaling pathway	P00980	IRS1/2	RAT|RGD=2922|UniProtKB=P35570	Insulin receptor substrate 1	IC	12701063	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	PANTR|Ensembl=ENSPTRG00000019361|UniProtKB=H2QUV3	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	TAS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IGI	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02920	dCTP deaminase	PANTR|Ensembl=ENSPTRG00000018669|UniProtKB=H2QTU8	Adenosine deaminase, tRNA-specific 2, TAD2 homolog	ISS			PTHR11079:SF92	TRNA-SPECIFIC ADENOSINE DEAMINASE 2
P04393	Ras Pathway	P04542	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	ARATH|TAIR=AT3G03800|UniProtKB=Q9SRV7	Putative syntaxin-131	IC			PTHR19957:SF144	SYNTAXIN-132-RELATED
P00010	B cell activation	P00381	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00060	Ubiquitin proteasome pathway	P01491	E2	CHICK|Ensembl=ENSGALG00000012311|UniProtKB=F6SQB5	Uncharacterized protein	ISS			PTHR24068:SF48	UBIQUITIN-CONJUGATING ENZYME E2 D3
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00025	Hedgehog signaling pathway	P00682	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	10693759	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00941	Integrin alpha	CANLF|Ensembl=ENSCAFG00000014145|UniProtKB=F1PRU9	Uncharacterized protein	IPI	3487386	PubMed	PTHR23220:SF73	INTEGRIN ALPHA-IIB
P04393	Ras Pathway	P04578	Rho	CAEEL|WormBase=WBGene00004357|UniProtKB=Q22038	Ras-like GTP-binding protein rhoA	IDA	7798239	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P05734	Synaptic vesicle trafficking	P05779	Synaptobrevin	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	RCA	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P06587	Nicotine pharmacodynamics pathway	P06597	CDK5	TAKRU|Ensembl=ENSTRUG00000004034|UniProtKB=H2SAY8	Uncharacterized protein	ISS	10604473,	PubMed	PTHR24056:SF46	CYCLIN-DEPENDENT-LIKE KINASE 5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IDA	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	BOVIN|Ensembl=ENSBTAG00000009702|UniProtKB=F1N775	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF368	MYOSIN-8
P00017	DNA replication	P00535	5' to 3' Exoribonulcease	ARATH|TAIR=AT1G75660|UniProtKB=Q9FQ03	5'-3' exoribonuclease 3	NAS	18410905	gi	PTHR12341:SF30	5'-3' EXORIBONUCLEASE 2-RELATED
P00048	PI3 kinase pathway	P01177	P110ACT	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00252	Grb2	DANRE|ZFIN=ZDB-GENE-040426-1975|UniProtKB=Q6PC73	Growth factor receptor-bound protein 2	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05917	Opioid proopiomelanocortin pathway	P06011	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	MACMU|Ensembl=ENSMMUG00000017256|UniProtKB=F7GWW5	Uncharacterized protein	ISS	14526084	PubMed	PTHR10037:SF137	VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1G
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	HUMAN|HGNC=16767|UniProtKB=Q8TCU5	Glutamate receptor ionotropic, NMDA 3A	IC	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00004	Alzheimer disease-presenilin pathway	P00145	CD44	PANTR|Ensembl=ENSPTRG00000003501|UniProtKB=H2Q3E8	Uncharacterized protein	ISS	14871815	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00906	Rap1	MOUSE|MGI=MGI=97852|UniProtKB=P62835	Ras-related protein Rap-1A	ISS	10476970	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MACMU|Ensembl=ENSMMUG00000004886|UniProtKB=F7AGT9	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	DAPPU|EnsemblGenome=DAPPUDRAFT_306746|UniProtKB=E9GYE9	Putative uncharacterized protein	ISS	9658176	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IGI	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CAEEL|WormBase=WBGene00001612|UniProtKB=P34299	Glutamate receptor 1	IC	12941441	PubMed	PTHR18966:SF297	GLUTAMATE RECEPTOR 1
P04393	Ras Pathway	P04570	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	PANTR|Ensembl=ENSPTRG00000001202|UniProtKB=H2PZT8	Uncharacterized protein	ISS			PTHR24241:SF116	GONADOTROPIN-RELEASING HORMONE II RECEPTOR-RELATED
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	IC	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00840	GPRK	MOUSE|MGI=MGI=87940|UniProtKB=Q99MK8	Beta-adrenergic receptor kinase 1	IDA	8288567	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P00005	Angiogenesis	P00189	Fzd	RAT|RGD=631406|UniProtKB=Q8CHL0	Frizzled-5	ISS	8717036	PubMed	PTHR11309:SF126	FRIZZLED-5
P00047	PDGF signaling pathway	P01148	Grb2	HUMAN|HGNC=4562|UniProtKB=Q13588	GRB2-related adapter protein	ISS	11971956	PubMed	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IGI	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00973	PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	STRCO|Gene=CAB76883|UniProtKB=Q9L0Z8	Putative inosine monophosphate dehydrogenase	ISS			PTHR43170:SF4	GMP REDUCTASE 2
P05731	GABA-B receptor II signaling	P05755	Gbeta	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	NEUCR|EnsemblGenome=EFNCRG00000000159|UniProtKB=F5HH30	Guanine nucleotide-binding protein beta subunit	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00035	Interferon-gamma signaling pathway	P00952	Jak2	RAT|RGD=2939|UniProtKB=Q62689	Tyrosine-protein kinase JAK2	TAS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00035	Interferon-gamma signaling pathway	P00956	SOCS	CHICK|Gene=SOCS3|UniProtKB=Q90X67	Suppressor of cytokine signaling 3	TAS	15032587	PubMed	PTHR44534:SF3	SUPPRESSOR OF CYTOKINE SIGNALING 3
P00001	Adrenaline and noradrenaline biosynthesis	P00067	MAO	MOUSE|MGI=MGI=96916|UniProtKB=Q8BW75	Amine oxidase [flavin-containing] B	ISS	90344230	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=19300|UniProtKB=Q8N4C7	Syntaxin-19	IC	11067767	PubMed	PTHR19957:SF29	SYNTAXIN-19
P02740	De novo pyrimidine ribonucleotides biosythesis	P02926	Aspartate carbamoyltransferase	SULSO|EnsemblGenome=SSO0614|UniProtKB=Q9UX08	Aspartate carbamoyltransferase	ISS			PTHR11405:SF16	ASPARTATE CARBAMOYLTRANSFERASE, CHLOROPLASTIC
P00048	PI3 kinase pathway	P01179	PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05754	Ggamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00048	PI3 kinase pathway	P01189	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	RAT|RGD=2743|UniProtKB=P31421	Metabotropic glutamate receptor 2	IDA			PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00059	p53 pathway	P01481	ATM/ATR	BOVIN|Ensembl=ENSBTAG00000003111|UniProtKB=E1BEI6	Uncharacterized protein	ISS	10196661	PubMed	PTHR11139:SF72	SERINE-PROTEIN KINASE ATM
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	CRYNJ|EnsemblGenome=CNJ01230|UniProtKB=P0CS12	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00013	Cell cycle	P00481	APC	PANTR|Ensembl=ENSPTRG00000016480|UniProtKB=H2QQ85	Anaphase-promoting complex subunit 10	ISS	7657035	gi	PTHR12936:SF0	ANAPHASE-PROMOTING COMPLEX SUBUNIT 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	IDA	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00056	VEGF signaling pathway	P01411	Ras	CAEEL|WormBase=WBGene00002335|UniProtKB=P22981	Ras protein let-60	ISS	12024031	PubMed	PTHR24070:SF385	GTPASE HRAS
P00048	PI3 kinase pathway	G01546	Cyclin d	MACMU|Ensembl=ENSMMUG00000002368|UniProtKB=F7BZY1	Uncharacterized protein	ISS	12356903	PubMed	PTHR10177:SF67	G1/S-SPECIFIC CYCLIN-D1
P02738	De novo purine biosynthesis	P02899	GMP synthase	THEKO|EnsemblGenome=TK0193|UniProtKB=Q5JFM1	GMP synthase [glutamine-hydrolyzing] subunit B	ISS			PTHR11922:SF2	GMP SYNTHASE  GLUTAMINE-HYDROLYZING
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00048	PI3 kinase pathway	P01192	p110	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00807	Actin	CAEEL|WormBase=WBGene00000066|UniProtKB=P10986	Actin-4	IDA	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00053	T cell activation	P01336	Jnk	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P05918	p38 MAPK pathway	P06044	GADD45	MOUSE|MGI=MGI=107799|UniProtKB=P48316	Growth arrest and DNA damage-inducible protein GADD45 alpha	RCA	10097101	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P00049	Parkinson disease	P01211	ERK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	IDA	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CHICK|Ensembl=ENSGALG00000017238|UniProtKB=F1NWG3	Uncharacterized protein	IDA			PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00057	Wnt signaling pathway	P01432	Beta-Catenin	MACMU|Ensembl=ENSMMUG00000014627|UniProtKB=F7GNE4	Catenin beta-1	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00019	Endothelin signaling pathway	P00566	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	97449291	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00018	EGF receptor signaling pathway	P00562	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00054	Toll receptor signaling pathway	P01375	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	MONDO|Ensembl=ENSMODG00000014431|UniProtKB=F7ATX4	Clathrin heavy chain	ISS	9388255	PubMed	PTHR10292:SF7	CLATHRIN HEAVY CHAIN 1
P00021	FGF signaling pathway	P00623	FGF	RAT|RGD=620162|UniProtKB=G3V7X1	Fibroblast growth factor	ISS	8790420	PubMed	PTHR11486:SF67	FIBROBLAST GROWTH FACTOR 11
P00029	Huntington disease	P00796	Kainate receptor	MOUSE|MGI=MGI=95817|UniProtKB=Q8BMF5	Glutamate receptor ionotropic, kainate 4	ISS	1648176	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	IDA	14684598	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00001	Adrenaline and noradrenaline biosynthesis	P00070	VAT2	PANTR|Ensembl=ENSPTRG00000002979|UniProtKB=H2Q2M8	Uncharacterized protein	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MACMU|Ensembl=ENSMMUG00000010266|UniProtKB=F6PV18	Uncharacterized protein	ISS	6309844	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	TRYB2|Gene=Tb927.7.5480|UniProtKB=Q582G3	Bifunctional dihydrofolate reductase-thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	DANRE|ZFIN=ZDB-GENE-041114-26|UniProtKB=F1RE11	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00774	Dynein complex	MONDO|Ensembl=ENSMODG00000014773|UniProtKB=F7G757	Uncharacterized protein	ISS	9454836	PubMed	PTHR11886:SF35	DYNEIN LIGHT CHAIN 2, CYTOPLASMIC
P00010	B cell activation	P00398	IP3R	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	IGI	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	PANTR|Ensembl=ENSPTRG00000019617|UniProtKB=Q2QLE7	Protein Wnt-2	ISS	8717036	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00019	Endothelin signaling pathway	P00591	PLCbeta	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	DROME|FlyBase=FBgn0001291|UniProtKB=P18289	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF35	TRANSCRIPTION FACTOR AP-1
P00049	Parkinson disease	P01208	Hsp70	PRIPA|Gene=PPA27506|UniProtKB=H3FYW1	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=2136749|UniProtKB=Q6PB90	Protocadherin beta-14	IDA	8120095	PubMed	PTHR24028:SF139	PROTOCADHERIN BETA-14
P00054	Toll receptor signaling pathway	P01375	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04398	p53 pathway feedback loops 2	P04661	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P02752	Mannose metabolism	P03019	P-Mannose mutase	LEIMA|EnsemblGenome=LmjF.36.1960|UniProtKB=Q4Q1M7	Phosphomannomutase	ISS	11689705	PubMed	PTHR10466:SF0	PHOSPHOMANNOMUTASE
P00048	PI3 kinase pathway	P01185	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P06959	CCKR signaling map	P07047	p62 SRC	HUMAN|HGNC=11283|UniProtKB=P12931	Proto-oncogene tyrosine-protein kinase Src	RCA	8074224	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00049	Parkinson disease	P01221	Torsin A	RAT|RGD=628863|UniProtKB=Q68G38	Torsin-1A	ISS	12421356	PubMed	PTHR10760:SF15	TORSIN-1A
P00019	Endothelin signaling pathway	P00572	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IGI	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00024	Glycolysis	P00679	Aldolase	MONDO|Ensembl=ENSMODG00000015696|UniProtKB=F7E0Q7	Fructose-bisphosphate aldolase	ISS	74094688	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00029	Huntington disease	P00793	Arfaptin-2	MONDO|Ensembl=ENSMODG00000018580|UniProtKB=F7FRA7	Uncharacterized protein	ISS	11854752	PubMed	PTHR12141:SF3	ARFAPTIN-2
P00048	PI3 kinase pathway	G01546	Cyclin d	RAT|RGD=68384|UniProtKB=P39948	G1/S-specific cyclin-D1	ISS	93330551	PubMed	PTHR10177:SF67	G1/S-SPECIFIC CYCLIN-D1
P00025	Hedgehog signaling pathway	P00682	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	IDA	91072385	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00564	Rac	ENTHI|EnsemblGenome=EHI_197840|UniProtKB=C4M8K6	Rho family GTPase	IGI	97082968	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00055	Transcription regulation by bZIP transcription factor	P01396	TFIIFbeta	RAT|RGD=620772|UniProtKB=Q01750	General transcription factor IIF subunit 2	ISS			PTHR10445:SF0	GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	BOVIN|Ensembl=ENSBTAG00000047648|UniProtKB=G5E6N8	Uncharacterized protein	ISS	SYT2_RAT	SPACC	PTHR10024:SF223	SYNAPTOTAGMIN-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IC	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00203	Erk	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	ARATH|TAIR=AT3G24090|UniProtKB=Q9LIP9	Glutamine-fructose-6-phosphate transaminase 2	ISS			PTHR10937:SF0	GH12731P-RELATED
P00053	T cell activation	P01312	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00025	Hedgehog signaling pathway	P00682	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	HUMAN|HGNC=7883|UniProtKB=Q9UM47	Neurogenic locus notch homolog protein 3	IDA	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05734	Synaptic vesicle trafficking	P05778	SNAP-25	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	TAS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06009	K+ channel	RAT|RGD=61997|UniProtKB=O54912	Potassium channel subfamily K member 3	ISS	15282272	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MOUSE|MGI=MGI=97255|UniProtKB=Q02566	Myosin-6	ISS	89264452	PubMed	PTHR13140:SF721	MYOSIN-6
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IC	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01451	Galpha	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04397	p53 pathway by glucose deprivation	P04641	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00045	Notch signaling pathway	P01101	Su(H)	DANRE|ZFIN=ZDB-GENE-031117-1|UniProtKB=A4FTT3	Rbpja protein	ISS	9043084	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	BOVIN|Ensembl=ENSBTAG00000017981|UniProtKB=P46626	Beta-3 adrenergic receptor	IDA	11943840	PubMed	PTHR24248:SF3	BETA-3 ADRENERGIC RECEPTOR
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IC	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	10395542	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00046	Oxidative stress response	P01131	MKP5	CAEEL|WormBase=WBGene00007302|UniProtKB=Q9XVE7	Uncharacterized protein	TAS			PTHR10159:SF378	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01153	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00047	PDGF signaling pathway	P01159	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00018	EGF receptor signaling pathway	P00552	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	1764995	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	TAS			PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MONDO|Ensembl=ENSMODG00000020977|UniProtKB=F6S5B1	Uncharacterized protein (Fragment)	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04393	Ras Pathway	P04547	Ras	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	IDA	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	IPI	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04397	p53 pathway by glucose deprivation	P04641	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00589	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IGI	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	IC	8170357	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P06959	CCKR signaling map	P07232	CREB1	HUMAN|HGNC=2345|UniProtKB=P16220	Cyclic AMP-responsive element-binding protein 1	RCA	9852054	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=13829|UniProtKB=Q9GZT5	Protein Wnt-10a	TAS	11266476	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00029	Huntington disease	P00780	Microtubule	BOVIN|Ensembl=ENSBTAG00000004624|UniProtKB=E1B953	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P02755	Methylmalonyl pathway	P03033	Propionyl-CoA carboxylase	DEIRA|EnsemblGenome=DR_1316|UniProtKB=Q9RUR6	Methylmalonyl-CoA carboxyltransferase	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P00053	T cell activation	P01332	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=5292|UniProtKB=P30939	5-hydroxytryptamine receptor 1F	IDA	12441358	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00005	Angiogenesis	P00224	PDGF	MACMU|Ensembl=ENSMMUG00000005353|UniProtKB=F7GEA7	Uncharacterized protein	ISS	12629513	PubMed	PTHR11633:SF4	PLATELET-DERIVED GROWTH FACTOR D
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00845	Cyclooxygenase	RAT|RGD=3439|UniProtKB=Q63921	Prostaglandin G/H synthase 1	ISS	10668482	PubMed	PTHR11903:SF6	PROSTAGLANDIN G/H SYNTHASE 1
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000008269|UniProtKB=H2QBE4	Cadherin 3, type 1, P-cadherin (Placental)	ISS	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P02738	De novo purine biosynthesis	P02907	dADP kinase	RAT|RGD=1583004|UniProtKB=D3ZH90	Protein Nme5	ISS			PTHR11349:SF64	NUCLEOSIDE DIPHOSPHATE KINASE HOMOLOG 5
P00056	VEGF signaling pathway	P01407	Erk	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04393	Ras Pathway	P04556	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000000771|UniProtKB=F6SSS3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00021	FGF signaling pathway	P00634	MEKK1-5	CANLF|Ensembl=ENSCAFG00000000760|UniProtKB=E2R9L4	Uncharacterized protein	ISS	12052864	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	HUMAN|HGNC=4588|UniProtKB=O15399	Glutamate receptor ionotropic, NMDA 2D	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P02747	Histidine biosynthesis	P02991	Histidinephosphate aminotransferase	AQUAE|EnsemblGenome=aq_2084|UniProtKB=O67857	Histidinol-phosphate aminotransferase	ISS			PTHR43643:SF3	SUBFAMILY NOT NAMED
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	HUMAN|HGNC=704|UniProtKB=O15143	Actin-related protein 2/3 complex subunit 1B	ISS	12932731	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00018	EGF receptor signaling pathway	P00557	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	ISS	8700226	PubMed	PTHR10048:SF14	PI-3 KINASE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00995	c-Myc	RAT|RGD=3130|UniProtKB=P09416	Myc proto-oncogene protein	ISS	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	RCA	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00034	Integrin signalling pathway	P00916	Ras	CHICK|Ensembl=ENSGALG00000014033|UniProtKB=E1BTS2	Uncharacterized protein	ISS	3023884	PubMed	PTHR24070:SF186	GTPASE KRAS
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	DANRE|ZFIN=ZDB-GENE-070705-74|UniProtKB=B8A569	Uncharacterized protein	ISS			PTHR13140:SF676	MYOSIN, HEAVY POLYPEPTIDE 2, FAST MUSCLE SPECIFIC
P00034	Integrin signalling pathway	P00922	Collagen	MOUSE|MGI=MGI=88459|UniProtKB=Q04857	Collagen alpha-1(VI) chain	IDA	10778855	PubMed	PTHR44172:SF3	COLLAGEN ALPHA-1 VI  CHAIN
P00049	Parkinson disease	P01227	20S proteasome	MONDO|Ensembl=ENSMODG00000019742|UniProtKB=F6WNU0	Proteasome subunit beta type	ISS	12859888	PubMed	PTHR11599:SF42	PROTEASOME SUBUNIT BETA TYPE-7
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=12785|UniProtKB=Q9Y6F9	Protein Wnt-6	IDA	8717036	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P04393	Ras Pathway	P04559	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	1764995	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00029	Huntington disease	P00797	p53	MACMU|Ensembl=ENSMMUG00000008639|UniProtKB=P56424	Cellular tumor antigen p53	ISS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P04393	Ras Pathway	P04558	p38	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	IC	91056091	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P05917	Opioid proopiomelanocortin pathway	P06009	K+ channel	BOVIN|Ensembl=ENSBTAG00000018193|UniProtKB=E1BHX8	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00052	TGF-beta signaling pathway	P01275	P38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	MACMU|Ensembl=ENSMMUG00000023317|UniProtKB=F6Y514	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00029	Huntington disease	P00778	NMDA receptor	MACMU|Ensembl=ENSMMUG00000001661|UniProtKB=F7GR69	Uncharacterized protein	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00015	Circadian clock system	G01501	cry	MACMU|Ensembl=ENSMMUG00000021808|UniProtKB=F7ENG9	Cryptochrome-1	ISS	10217146	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	ORNAN|Ensembl=ENSOANG00000011383|UniProtKB=F6T6T3	Uncharacterized protein	ISS	10664585	PubMed	PTHR11462:SF7	TRANSCRIPTION FACTOR JUN-D
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MONDO|Ensembl=ENSMODG00000008826|UniProtKB=F6XUU0	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00590	IP3 R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01094	gamma	CHICK|Gene=CHRNG|UniProtKB=P02713	Acetylcholine receptor subunit gamma	ISS	95224005	PubMed	PTHR18945:SF60	ACETYLCHOLINE RECEPTOR SUBUNIT GAMMA
P00011	Blood coagulation	P00444	FIX	HUMAN|HGNC=3551|UniProtKB=P00740	Coagulation factor IX	ISS	14270123	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P00049	Parkinson disease	P01227	20S proteasome	MONDO|Ensembl=ENSMODG00000007303|UniProtKB=F7FBS3	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF12	PROTEASOME SUBUNIT ALPHA TYPE-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	RCA	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-478663|UniProtKB=F7EG64	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00053	T cell activation	P01324	rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00021	FGF signaling pathway	P00629	PP2A	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04546	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	P00539	14-3-3	SCHMA|EnsemblGenome=Smp_009760|UniProtKB=G4LUI9	14-3-3 protein, putative	IGI	10407019	PubMed	PTHR18860:SF13	14-3-3 PROTEIN ZETA
P04393	Ras Pathway	P04572	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	MYCTU|EnsemblGenome=Rv0070c|UniProtKB=P9WGI7	Serine hydroxymethyltransferase 2	ISS			PTHR11680:SF21	SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00054	Toll receptor signaling pathway	P01376	Uev1A	CAEEL|WormBase=WBGene00006730|UniProtKB=O45495	Ubiquitin-conjugating enzyme E2 variant 1	ISS			PTHR43915:SF5	LD28904P
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	MACMU|Ensembl=ENSMMUG00000014817|UniProtKB=F6VXD8	Uncharacterized protein	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00047	PDGF signaling pathway	P01165	SRF	MACMU|Ensembl=ENSMMUG00000000033|UniProtKB=F7G4D2	Uncharacterized protein	ISS	15647354	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00010	B cell activation	P00381	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	BOVIN|Ensembl=ENSBTAG00000013047|UniProtKB=E1BLE8	Uncharacterized protein	ISS			PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00048	PI3 kinase pathway	P01177	P110ACT	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	IC	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MACMU|Ensembl=ENSMMUG00000019112|UniProtKB=F6T8S6	N-methyl D-aspartate receptor subtype 2B	ISS	11554554	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00006	Apoptosis signaling pathway	P00269	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01178	Grb2	CAEEL|WormBase=WBGene00004774|UniProtKB=P29355	Sex muscle abnormal protein 5	TAS	4504111	gi	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00079	alpha7 nicotinic acetylcholine receptor	MACMU|Ensembl=ENSMMUG00000022577|UniProtKB=Q866A2	Neuronal acetylcholine receptor subunit alpha-7	ISS	11404397	PubMed	PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	CHICK|Ensembl=ENSGALG00000027629|UniProtKB=Q5ZJ03	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04396	Vitamin D metabolism and pathway	P04601	25-Hydroxylase	MACMU|Ensembl=ENSMMUG00000022144|UniProtKB=F7H3A6	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	ISS	10232681	PubMed	PTHR24291:SF3	25-HYDROXYVITAMIN D-1 ALPHA HYDROXYLASE, MITOCHONDRIAL
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	METJA|EnsemblGenome=MJ_0507|UniProtKB=Q57930	TATA-box-binding protein	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00005	Angiogenesis	P00223	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05915	Opioid proenkephalin pathway	P05988	peptide E	MOUSE|MGI=MGI=104629|UniProtKB=P22005	Proenkephalin-A	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00029	Huntington disease	P00793	Arfaptin-2	MACMU|Ensembl=ENSMMUG00000007731|UniProtKB=F7C8Z7	ADP-ribosylation factor-interacting protein 2	ISS	11854752	PubMed	PTHR12141:SF3	ARFAPTIN-2
P00006	Apoptosis signaling pathway	P00321	HSP70	DROME|FlyBase=FBgn0001217|UniProtKB=P11146	Heat shock 70 kDa protein cognate 2	ISS	12150907	PubMed	PTHR19375:SF256	HSP70 PROTEIN-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	PANTR|Ensembl=ENSPTRG00000007913|UniProtKB=H2QAT6	Uncharacterized protein	ISS	2278997	PubMed	PTHR23037:SF32	INTERLEUKIN-4 RECEPTOR SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	HUMAN|HGNC=4046|UniProtKB=Q9H461	Frizzled-8	TAS	11212302	PubMed	PTHR11309:SF90	FRIZZLED-8
P00029	Huntington disease	P00807	Actin	BOVIN|Gene=ACTG2|UniProtKB=Q5E9B5	Actin, gamma-enteric smooth muscle	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04395	Vasopressin synthesis	P04599	Amidating Enzyme	CAEBR|Gene=CBG22199|UniProtKB=A8Y1S2	Protein CBR-PGHM-1	ISS	3153462	PubMed	PTHR10680:SF14	PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	IC	15313841	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00562	p38	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	IGI	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MOUSE|MGI=MGI=1339710|UniProtKB=G3UW82	MCG140437, isoform CRA_d	ISS	89264452	PubMed	PTHR13140:SF385	MYOSIN-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	XENTR|Xenbase=XB-GENE-1013749|UniProtKB=A0JP99	LOC100036644 protein	ISS			PTHR24361:SF345	SERINE/THREONINE-PROTEIN KINASE PAK 4
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	CHICK|Gene=FZD7|UniProtKB=O57329	Frizzled-7	TAS	11212302	PubMed	PTHR11309:SF31	FRIZZLED-7
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00574	Big ET1-4	PANTR|Ensembl=ENSPTRG00000017730|UniProtKB=H2QSB1	Uncharacterized protein	ISS	15117818	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P02748	Isoleucine biosynthesis	P02995	Threonine dehydratase	SULSO|EnsemblGenome=SSO0248|UniProtKB=Q980P1	Threonine dehydratase catabolic (Threonine deaminase) (TdcB)	ISS			PTHR43419:SF8	THREONINE AMMONIA-LYASE
P05918	p38 MAPK pathway	P06015	p38gamma	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00006	Apoptosis signaling pathway	P00322	Cytochrome C	TAKRU|Ensembl=ENSTRUG00000002170|UniProtKB=H2RXW2	Uncharacterized protein	ISS	4358609	PubMed	PTHR11961:SF12	CYTOCHROME C
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P05734	Synaptic vesicle trafficking	P05775	Synapsin	MACMU|Ensembl=ENSMMUG00000011420|UniProtKB=F6VRW8	Uncharacterized protein	ISS	15265868	PubMed	PTHR10841:SF22	SYNAPSIN-1
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	RAT|RGD=619965|UniProtKB=P26769	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00021	FGF signaling pathway	P00645	Rac	DICDI|dictyBase=DDB_G0268622|UniProtKB=P34145	Rho-related protein rac1B	ISS	12932731	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00048	PI3 kinase pathway	P01182	Ras	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	ISS	22097630	PubMed	PTHR24070:SF189	GTPASE NRAS
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P02743	Formyltetrahydroformate biosynthesis	P02952	Methylene tetrahydrofolate dehydrogenase	CHLTR|EnsemblGenome=CT_078|UniProtKB=O84081	Bifunctional protein FolD	ISS			PTHR10025:SF46	BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P02771	Pyrimidine Metabolism	P03127	Beta-Ureidopropionase	CAEBR|Gene=CBG02618|UniProtKB=A8WTW8	Protein CBR-UPB-1	ISS	17533173	gi	PTHR43674:SF2	BETA-UREIDOPROPIONASE
P00053	T cell activation	P01331	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	RAT|RGD=2027|UniProtKB=P63269	Actin, gamma-enteric smooth muscle	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	HUMAN|HGNC=4572|UniProtKB=P42262	Glutamate receptor 2	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00384	p38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00036	Interleukin signaling pathway	P00965	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04567	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P02738	De novo purine biosynthesis	P02891	GDP kinase	DROME|FlyBase=FBgn0030573|UniProtKB=Q9VY27	Nucleoside diphosphate kinase	ISS			PTHR11349:SF70	NUCLEOSIDE DIPHOSPHATE KINASE 6
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	CANLF|Ensembl=ENSCAFG00000016335|UniProtKB=J9NXY2	Uncharacterized protein	ISS			PTHR23050:SF322	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00938	Cdc42	IXOSC|EnsemblGenome=ISCW003614|UniProtKB=B7PHY7	Cdc42 protein, putative	ISS	15723050	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00029	Huntington disease	P00777	CBP	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P02738	De novo purine biosynthesis	P02902	ADP reductase	CANAL|CGD=CAL0001524|UniProtKB=Q5A0N3	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	SCHPO|PomBase=SPAC15E1.04|UniProtKB=Q9UTI7	Probable thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P05912	Dopamine receptor mediated signaling pathway	P05951	CDK5	TAKRU|Ensembl=ENSTRUG00000004034|UniProtKB=H2SAY8	Uncharacterized protein	ISS	12372285	PubMed	PTHR24056:SF46	CYCLIN-DEPENDENT-LIKE KINASE 5
P02757	O-antigen biosynthesis	P03050	dTDP-4-dehydrorhamnose reductase	HUMAN|HGNC=6905|UniProtKB=Q9NZL9	Methionine adenosyltransferase 2 subunit beta	ISS			PTHR10491:SF4	METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA
P04395	Vasopressin synthesis	P04590	Vasopressin	RAT|RGD=3238|UniProtKB=P01179	Oxytocin-neurophysin 1	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00034	Integrin signalling pathway	P00936	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	TAS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01076	CAT	MACMU|Ensembl=ENSMMUG00000004692|UniProtKB=F6RM01	Uncharacterized protein	ISS	97225904	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	XENTR|Xenbase=XB-GENE-490883|UniProtKB=Q6NVA9	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	MOUSE|MGI=MGI=88276|UniProtKB=Q02248	Catenin beta-1	TAS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00807	Actin	TRIAD|EnsemblGenome=TriadG49626|UniProtKB=B3RKR4	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00049	Parkinson disease	P01208	Hsp70	MONDO|Ensembl=ENSMODG00000019764|UniProtKB=F6WMM9	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00021	FGF signaling pathway	P00642	MEK1-2	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CHICK|Ensembl=ENSGALG00000028749|UniProtKB=Q5ZMQ2	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00006	Apoptosis signaling pathway	P00321	HSP70	MOUSE|MGI=MGI=95835|UniProtKB=P20029	78 kDa glucose-regulated protein	ISS	10934466	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00049	Parkinson disease	P01230	Src kinase	CANLF|Ensembl=ENSCAFG00000003995|UniProtKB=E2RC09	Tyrosine-protein kinase	ISS	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95809|UniProtKB=P23819	Glutamate receptor 2	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	10540223	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00059	p53 pathway	G04694	p110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00010	B cell activation	P00373	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00056	VEGF signaling pathway	P01418	Paxillin	RAT|RGD=1304981|UniProtKB=Q5M852	Leupaxin	ISS			PTHR24216:SF23	LEUPAXIN
P00052	TGF-beta signaling pathway	P01286	TGFbeta	BOVIN|Ensembl=ENSBTAG00000001019|UniProtKB=Q08DX6	Growth/differentiation factor 10	ISS	9759503	PubMed	PTHR11848:SF145	GROWTH/DIFFERENTIATION FACTOR 10
P00048	PI3 kinase pathway	P01185	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00013	Cell cycle	P00489	CdkC	CAEEL|WormBase=WBGene00000871|UniProtKB=O01501	G1/S-specific cyclin-E	RCA			PTHR10177:SF344	G1/S-SPECIFIC CYCLIN-E
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CAEEL|WormBase=WBGene00001519|UniProtKB=Q9U7D5	Muscarinic acetylcholine receptor gar-3	IDA			PTHR43914:SF8	MUSCARINIC ACETYLCHOLINE RECEPTOR GAR-3
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00046	Oxidative stress response	P01135	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	HUMAN|HGNC=1602|UniProtKB=P32246	C-C chemokine receptor type 1	IDA	9886417	PubMed	PTHR10489:SF711	C-C CHEMOKINE RECEPTOR TYPE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06830	AMPK	MOUSE|MGI=MGI=1336167|UniProtKB=Q9R078	5'-AMP-activated protein kinase subunit beta-1	RCA			PTHR10343:SF16	5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05916	Opioid prodynorphin pathway	P05998	Kappa Receptor	RAT|RGD=69426|UniProtKB=P34975	Kappa-type opioid receptor	RCA	11259487	PubMed	PTHR24229:SF1	KAPPA-TYPE OPIOID RECEPTOR
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00892	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	8479536	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	MOUSE|MGI=MGI=1339975|UniProtKB=O88643	Serine/threonine-protein kinase PAK 1	ISS	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00020	FAS signaling pathway	P00611	Gelsolin	RAT|RGD=1303089|UniProtKB=Q68FP1	Gelsolin	ISS	9323209	PubMed	PTHR11977:SF29	GELSOLIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	IDA	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00017	DNA replication	P00535	5' to 3' Exoribonulcease	RAT|RGD=1309713|UniProtKB=D4ABN8	Protein Xrn1	ISS	97201457	PubMed	PTHR12341:SF7	5'-3' EXORIBONUCLEASE 1
P00047	PDGF signaling pathway	P01140	ELK	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	ISS	11151091	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P02772	Pyruvate metabolism	P03141	Citrate Synthetase	MYCTU|EnsemblGenome=Rv0889c|UniProtKB=P9WPD3	Putative citrate synthase 2	ISS	9634230	PubMed	PTHR11739:SF23	SUBFAMILY NOT NAMED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MOUSE|MGI=MGI=2150393|UniProtKB=Q91ZU9	Glutamate receptor ionotropic, NMDA 3B	IC	14698601	PubMed	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P00060	Ubiquitin proteasome pathway	P01491	E2	XENTR|Xenbase=XB-GENE-969236|UniProtKB=Q6GL05	Ubiquitin-conjugating enzyme E2A (RAD6 homolog)	ISS			PTHR43898:SF4	UBIQUITIN-CONJUGATING ENZYME E2 A
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00047	PDGF signaling pathway	P01143	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	PANTR|Ensembl=ENSPTRG00000000843|UniProtKB=H2QZN8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	BOVIN|Ensembl=ENSBTAG00000016198|UniProtKB=E1B8D6	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00018	EGF receptor signaling pathway	P00552	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00019	Endothelin signaling pathway	P00590	IP3 R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	IC	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01175	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	7798194	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00029	Huntington disease	P00805	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	IC	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MOUSE|MGI=MGI=1346047|UniProtKB=Q9Z0J7	Growth/differentiation factor 15	TAS	10779363	PubMed	PTHR11848:SF78	GROWTH/DIFFERENTIATION FACTOR 15
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	CHICK|Ensembl=ENSGALG00000005198|UniProtKB=F1P4J0	Ribosomal protein S6 kinase	ISS	11861821	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	IC	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P05731	GABA-B receptor II signaling	P05752	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00060	Ubiquitin proteasome pathway	P01492	E1	CANLF|Ensembl=ENSCAFG00000006548|UniProtKB=F6Y460	Uncharacterized protein	ISS			PTHR10953:SF6	NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT
P02748	Isoleucine biosynthesis	P02997	Acetolactate synthase	STRCO|Gene=CAB37588|UniProtKB=Q9Z567	Acetolactate synthase	ISS			PTHR18968:SF116	ACETOLACTATE SYNTHASE ISOZYME 3 LARGE SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IDA	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P05918	p38 MAPK pathway	P06031	p38alpha	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-010705-1|UniProtKB=Q90Z40	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00059	p53 pathway	G04699	BAI-1	PANTR|Ensembl=ENSPTRG00000018325|UniProtKB=H2QT94	Uncharacterized protein	ISS			PTHR12011:SF40	ADHESION G PROTEIN-COUPLED RECEPTOR B3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00029	Huntington disease	P00807	Actin	CHICK|Gene=ACTR2|UniProtKB=P53488	Actin-related protein 2	ISS	11889126	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00012	Cadherin signaling pathway	P00467	alpha-catenin	HUMAN|HGNC=2510|UniProtKB=P26232	Catenin alpha-2	IDA	1768802	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	RAT|RGD=3187|UniProtKB=Q07008	Neurogenic locus notch homolog protein 1	IDA	1764995	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00021	FGF signaling pathway	P00643	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00321	HSP70	DANRE|ZFIN=ZDB-GENE-110713-1|UniProtKB=Q6PH56	Hsp70 protein	ISS	12150907	PubMed	PTHR19375:SF256	HSP70 PROTEIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	MOUSE|MGI=MGI=96606|UniProtKB=P24063	Integrin alpha-L	IDA	3487386	PubMed	PTHR23220:SF84	INTEGRIN ALPHA-L
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	HUMAN|HGNC=9871|UniProtKB=P20936	Ras GTPase-activating protein 1	TAS	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00007	Axon guidance mediated by semaphorins	P00339	CRMP	BOVIN|Ensembl=ENSBTAG00000017780|UniProtKB=F1MYK4	Uncharacterized protein	ISS			PTHR11647:SF55	DIHYDROPYRIMIDINASE-RELATED PROTEIN 4
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00054	Toll receptor signaling pathway	P01355	AP1	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00036	Interleukin signaling pathway	P00965	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	20384797	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	ARATH|TAIR=AT3G57370|UniProtKB=Q9M2L0	Cyclin family protein	ISS			PTHR11618:SF37	CYCLIN FAMILY PROTEIN-RELATED
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	MOUSE|MGI=MGI=2150393|UniProtKB=Q91ZU9	Glutamate receptor ionotropic, NMDA 3B	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00021	FGF signaling pathway	P00629	PP2A	CHICK|Ensembl=ENSGALG00000011840|UniProtKB=F1NLM6	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00036	Interleukin signaling pathway	P00990	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00049	Parkinson disease	P01238	14-3-3	ORYSJ|EnsemblGenome=OS08G0480800|UniProtKB=Q84J55	14-3-3-like protein GF14-A	ISS	10407019	PubMed	PTHR18860:SF26	14-3-3 FAMILY PROTEIN-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00056	VEGF signaling pathway	P01419	Ets	HUMAN|HGNC=3488|UniProtKB=P14921	Protein C-ets-1	IEP	3060801	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00010	B cell activation	P00398	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IGI	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00054	Toll receptor signaling pathway	P01368	MKK2	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00036	Interleukin signaling pathway	P00990	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05913	Enkephalin release	P05977	G-Protein (s)	CHICK|Ensembl=ENSGALG00000001334|UniProtKB=F1NLV4	Uncharacterized protein	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	CANLF|Ensembl=ENSCAFG00000009203|UniProtKB=F1PVZ1	Muscarinic acetylcholine receptor	ISS	12181435	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04393	Ras Pathway	P04558	p38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IDA	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	IGI	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	MACMU|Ensembl=ENSMMUG00000004886|UniProtKB=F7AGT9	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00060	Ubiquitin proteasome pathway	P01490	E3	MACMU|Ensembl=ENSMMUG00000003339|UniProtKB=F7EGU5	E3 ubiquitin-protein ligase	ISS			PTHR11254:SF396	NEDD4-LIKE E3 UBIQUITIN-PROTEIN LIGASE WWP2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	TAKRU|Ensembl=ENSTRUG00000013071|UniProtKB=H2U8B2	Uncharacterized protein (Fragment)	ISS	85270494	PubMed	PTHR18945:SF489	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-9
P02757	O-antigen biosynthesis	P03050	dTDP-4-dehydrorhamnose reductase	MACMU|Ensembl=ENSMMUG00000013980|UniProtKB=F6RZ93	Methionine adenosyltransferase 2 subunit beta isoform 1	ISS			PTHR10491:SF4	METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IGI	10693759	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04393	Ras Pathway	P04542	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01319	PAK	BOVIN|Ensembl=ENSBTAG00000015670|UniProtKB=E1B7J7	Uncharacterized protein	ISS	7559398	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	CHICK|Ensembl=ENSGALG00000015835|UniProtKB=F1NZT2	Uncharacterized protein	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00009	Axon guidance mediated by netrin	P00366	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	ARATH|TAIR=AT3G47220|UniProtKB=Q6NMA7	Phosphoinositide phospholipase C 9	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00560	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00056	VEGF signaling pathway	P01408	Akt/PKB	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	ISS	7876156	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ORYSJ|EnsemblGenome=OS12G0163700|UniProtKB=Q0IPW3	Os12g0163700 protein	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00013	Cell cycle	P00480	Proteasome	MOUSE|MGI=MGI=1345192|UniProtKB=Q9WVJ2	26S proteasome non-ATPase regulatory subunit 13	ISS	99239941	PubMed	PTHR10539:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MACMU|Ensembl=ENSMMUG00000009606|UniProtKB=F7A5Y9	Uncharacterized protein	ISS			PTHR44152:SF4	HISTAMINE H3 RECEPTOR
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	BOVIN|Ensembl=ENSBTAG00000037429|UniProtKB=F1MGM3	Uncharacterized protein	ISS	12181435	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P00057	Wnt signaling pathway	P01465	Ggamma	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00053	T cell activation	P01331	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01162	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	RCA	9860142	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00005	Angiogenesis	P00238	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	BOVIN|Ensembl=ENSBTAG00000012516|UniProtKB=F1MUT8	Uncharacterized protein	ISS	96032356	PubMed	PTHR11958:SF22	EXCITATORY AMINO ACID TRANSPORTER 5
P00020	FAS signaling pathway	P00615	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MACMU|Ensembl=ENSMMUG00000012054|UniProtKB=F6TII3	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00018	EGF receptor signaling pathway	P00564	Rac	DANRE|ZFIN=ZDB-GENE-030131-5721|UniProtKB=Q7ZVI3	Ras homolog gene family, member Q	ISS	12932731	PubMed	PTHR24072:SF13	RHO-RELATED GTP-BINDING PROTEIN RHOQ
P02721	ATP synthesis	P02798	Cyt C	MACMU|Ensembl=ENSMMUG00000029549|UniProtKB=F7G769	Uncharacterized protein	ISS	4954366	PubMed	PTHR11961:SF15	CYTOCHROME C
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	HUMAN|HGNC=4584|UniProtKB=Q05586	Glutamate receptor ionotropic, NMDA 1	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MACMU|Ensembl=ENSMMUG00000012387|UniProtKB=F7EB20	Uncharacterized protein	ISS	12049732	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT1G59580|UniProtKB=Q39022	Mitogen-activated protein kinase 2	ISS	176948	OMIM	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P04398	p53 pathway feedback loops 2	P04658	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00035	Interferon-gamma signaling pathway	P00960	PTP	CANLF|Ensembl=ENSCAFG00000008894|UniProtKB=F1Q3J6	Tyrosine-protein phosphatase non-receptor type	ISS	8096088	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	ISS	11035810	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	BOVIN|Ensembl=ENSBTAG00000010529|UniProtKB=F1MP23	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF75	FRIZZLED-6
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00187	beta catenin	XENTR|Xenbase=XB-GENE-487200|UniProtKB=Q28GC2	Catenin (Cadherin associated protein), beta 1, 88kDa	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P00019	Endothelin signaling pathway	P00577	PI3K	CANAL|CGD=CAL0068551|UniProtKB=Q5AAR9	Phosphatidylinositol 3-kinase	IGI	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P02738	De novo purine biosynthesis	P02899	GMP synthase	CANLF|Ensembl=ENSCAFG00000008780|UniProtKB=F1P9U2	Uncharacterized protein	ISS			PTHR11922:SF2	GMP SYNTHASE  GLUTAMINE-HYDROLYZING
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	IDA	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00029	Huntington disease	P00780	Microtubule	PUCGT|EnsemblGenome=PGTG_12204|UniProtKB=E3KPL3	Tubulin beta chain	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	CANLF|Ensembl=ENSCAFG00000013778|UniProtKB=F6UQ33	Phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02723	Adenine and hypoxanthine salvage pathway	P02804	Hypoxanthine phosphoribosyl transferase	TAKRU|Ensembl=ENSTRUG00000003211|UniProtKB=H2S550	Uncharacterized protein	ISS			PTHR43340:SF6	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	XENTR|Xenbase=XB-GENE-1014725|UniProtKB=F6UGQ3	Uncharacterized protein	ISS	11679592	PubMed	PTHR23122:SF40	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00057	Wnt signaling pathway	P01458	Protein Kinase C	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MOUSE|MGI=MGI=99842|UniProtKB=Q02284	5-hydroxytryptamine receptor 1F	IDA			PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00021	FGF signaling pathway	P00624	14-3-3	DANRE|ZFIN=ZDB-GENE-011115-1|UniProtKB=Q6PC29	14-3-3 protein gamma-1	ISS	10407019	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00021	FGF signaling pathway	P00648	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IGI	3755548	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	188830	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00558	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IGI	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	CANLF|Ensembl=ENSCAFG00000009967|UniProtKB=F1PGZ2	Muscarinic acetylcholine receptor	ISS	11166329	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MONDO|Ensembl=ENSMODG00000012009|UniProtKB=F7AMI2	Uncharacterized protein	ISS	12441358	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00018	EGF receptor signaling pathway	P00558	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	BOVIN|Ensembl=ENSBTAG00000011723|UniProtKB=E1BKL6	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	CHICK|Ensembl=ENSGALG00000004693|UniProtKB=Q5ZJI7	Uncharacterized protein	ISS	12963527	gi	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00059	p53 pathway	G01563	MDM-2	HUMAN|HGNC=6974|UniProtKB=O15151	Protein Mdm4	ISS			PTHR13844:SF20	PROTEIN MDM4
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00015	Circadian clock system	P00502	Casein kinase I	XENTR|Xenbase=XB-GENE-481480|UniProtKB=Q5XGI6	Casein kinase 1, epsilon	ISS	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00005	Angiogenesis	P00243	Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	ISS	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P04393	Ras Pathway	P04567	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02779	Thiamin biosynthesis	P03170	Hydroxymethylpyrimidine phosphate kinase	STRCO|EnsemblGenome=CAA22406|UniProtKB=Q9ZBR6	Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase	ISS			PTHR20858:SF17	HYDROXYMETHYLPYRIMIDINE/PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P04393	Ras Pathway	P04556	Raf	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00046	Oxidative stress response	P01128	MEF-2	MACMU|Ensembl=ENSMMUG00000019836|UniProtKB=F7FUB3	Uncharacterized protein	ISS	11274345	PubMed	PTHR11945:SF25	MYOCYTE-SPECIFIC ENHANCER FACTOR 2C
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00566	ERK	ORYSJ|EnsemblGenome=OS06G0699400|UniProtKB=Q5Z859	Mitogen-activated protein kinase 4	ISS			PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01210	UCH-L1	MOUSE|MGI=MGI=103149|UniProtKB=Q9R0P9	Ubiquitin carboxyl-terminal hydrolase isozyme L1	ISS	12408865	PubMed	PTHR10589:SF19	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L1
P00011	Blood coagulation	P00444	FIX	MACMU|Ensembl=ENSMMUG00000020064|UniProtKB=F7GHR4	Uncharacterized protein	ISS	14270123	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P00048	PI3 kinase pathway	P01199	Galpha	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS			PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01411	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00477	GSK3beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	HUMAN|HGNC=10944|UniProtKB=P48664	Excitatory amino acid transporter 4	ISS	94365697	PubMed	PTHR11958:SF67	EXCITATORY AMINO ACID TRANSPORTER 4
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	15572354	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00047	PDGF signaling pathway	P01173	STAT	ANOGA|EnsemblGenome=AGAP000099|UniProtKB=Q7QEQ3	Signal transducer and activator of transcription	ISS			PTHR11801:SF43	SIGNAL TRANSDUCER AND TRANSCRIPTION ACTIVATOR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	BOVIN|Ensembl=ENSBTAG00000004806|UniProtKB=F1MJ90	Uncharacterized protein	ISS	10487978	PubMed	PTHR10749:SF8	PHOSPHORYLASE B KINASE REGULATORY SUBUNIT BETA
P05913	Enkephalin release	P05974	G-Protein (i)	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04393	Ras Pathway	P04543	MEKK1/4	BOVIN|Ensembl=ENSBTAG00000013790|UniProtKB=E1B847	Uncharacterized protein	ISS	12168099	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00546	GAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	IGI	14707121	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00005	Angiogenesis	P00223	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00030	Hypoxia response via HIF activation	P00824	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	TAS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00018	EGF receptor signaling pathway	P00547	PP2A	ARATH|TAIR=AT1G10430|UniProtKB=Q07098	Serine/threonine-protein phosphatase PP2A-2 catalytic subunit	ISS			PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00038	JAK/STAT signaling pathway	P01034	Jak	MACMU|Ensembl=ENSMMUG00000018566|UniProtKB=F6YLX1	Tyrosine-protein kinase	ISS	11929133	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	RAT|RGD=2035|UniProtKB=Q03343	Adenylate cyclase type 6	IDA	2491850	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	ORYSJ|EnsemblGenome=OS07G0114400|UniProtKB=Q8H386	Casein kinase II alpha subunit	ISS	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	HUMAN|HGNC=10483|UniProtKB=P21817	Ryanodine receptor 1	ISS	8930069	PubMed	PTHR13715:SF15	RYANODINE RECEPTOR 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00053	T cell activation	P01333	cdc42	MACMU|Ensembl=ENSMMUG00000022009|UniProtKB=F6RBZ7	Cell division control protein 42 homolog isoform 2	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00053	T cell activation	P01320	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00383	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00018	EGF receptor signaling pathway	P00541	Spry	PANTR|Ensembl=ENSPTRG00000005951|UniProtKB=H2Q7P2	Sprouty homolog 2	ISS	12815057	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00020	FAS signaling pathway	P00615	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000015130|UniProtKB=H2QMZ0	Uncharacterized protein	ISS	11067767	PubMed	PTHR19957:SF29	SYNTAXIN-19
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00029	Huntington disease	P00807	Actin	DICDI|dictyBase=DDB_G0289811|UniProtKB=Q54GX7	Actin-10	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02743	Formyltetrahydroformate biosynthesis	P02958	Dihydrofolate synthase	ARATH|TAIR=AT3G10160|UniProtKB=F4J2K2	Folylpolyglutamate synthase	ISS			PTHR11136:SF7	FOLYLPOLYGLUTAMATE SYNTHASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IDA	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	PANTR|Ensembl=ENSPTRG00000014365|UniProtKB=H2R0C8	Casein kinase 1, epsilon	ISS	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	DROME|FlyBase=FBgn0010280|UniProtKB=P47825	Transcription initiation factor TFIID subunit 4	ISS	10973244	PubMed	PTHR15138:SF14	IP01149P-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00049	Parkinson disease	P01227	20S proteasome	DROME|FlyBase=FBgn0261394|UniProtKB=P18053	Proteasome subunit alpha type-4	TAS	12859888	PubMed	PTHR11599:SF13	PROTEASOME SUBUNIT ALPHA TYPE-4
P00018	EGF receptor signaling pathway	P00547	PP2A	DICDI|dictyBase=DDB_G0290263|UniProtKB=Q9XZE5	Serine/threonine-protein phosphatase 2A catalytic subunit A	IGI	99379588	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04572	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00057	Wnt signaling pathway	P01443	Phospholipase C	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00006	Apoptosis signaling pathway	P00277	Bi1	ARATH|TAIR=AT4G17580|UniProtKB=F4JP81	BAX inhibitor-1 motif-containing protein	ISS			PTHR23291:SF34	BAX INHIBITOR 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	20331588	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05731	GABA-B receptor II signaling	P05754	Ggamma	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P02734	Chorismate biosynthesis	P02869	3-Dehydroquinate dehydratase	THEMA|EnsemblGenome=TM_0349|UniProtKB=Q9WYI4	3-dehydroquinate dehydratase	ISS			PTHR21272:SF3	SUBFAMILY NOT NAMED
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IDA	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00029	Huntington disease	P00780	Microtubule	ARATH|TAIR=AT5G62690|UniProtKB=Q56YW9	Tubulin beta-2 chain	IDA	12932731	PubMed	PTHR11588:SF259	TUBULIN BETA-2 CHAIN-RELATED
P00029	Huntington disease	P00778	NMDA receptor	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	9754712	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	HUMAN|HGNC=292|UniProtKB=P30520	Adenylosuccinate synthetase isozyme 2	IEP	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00057	Wnt signaling pathway	P01439	C-terminal Binding Protein	HUMAN|HGNC=2494|UniProtKB=Q13363	C-terminal-binding protein 1	IDA	10375506	PubMed	PTHR10996:SF128	C-TERMINAL-BINDING PROTEIN 1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	IC	91056091	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00022	General transcription by RNA polymerase I	P00655	UBF1	HUMAN|HGNC=12511|UniProtKB=P17480	Nucleolar transcription factor 1	ISS	14612424	PubMed	PTHR13711:SF216	NUCLEOLAR TRANSCRIPTION FACTOR 1
P00025	Hedgehog signaling pathway	P00682	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IDA	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00006	Apoptosis signaling pathway	P00260	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000015717|UniProtKB=F6SFA9	Serotonin receptor type 1B	ISS	11454663	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00805	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	BOVIN|Ensembl=ENSBTAG00000017139|UniProtKB=Q3ZBT5	Syntaxin-7	ISS	14570579	PubMed	PTHR19957:SF90	SYNTAXIN-7
P00057	Wnt signaling pathway	P01450	Bcl9	MONDO|Ensembl=ENSMODG00000018736|UniProtKB=F7EFL9	Uncharacterized protein	ISS	11955446	PubMed	PTHR15185:SF5	B-CELL CLL/LYMPHOMA 9 PROTEIN
P04393	Ras Pathway	P04547	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00019	Endothelin signaling pathway	P00586	Gq	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02774	Salvage pyrimidine deoxyribonucleotides	P03145	Uracil phosphorylase	METAC|EnsemblGenome=MA_3242|UniProtKB=Q8TL01	AMP phosphorylase	ISS	11932238	PubMed	PTHR10515:SF0	THYMIDINE PHOSPHORYLASE
P00053	T cell activation	P01294	NFAT	BOVIN|Ensembl=ENSBTAG00000004368|UniProtKB=F1MSU2	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00718	Phosphorylase a	MACMU|Ensembl=ENSMMUG00000022604|UniProtKB=F6Z728	Alpha-1,4 glucan phosphorylase	ISS	4318782	PubMed	PTHR11468:SF13	GLYCOGEN PHOSPHORYLASE, MUSCLE FORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	MONDO|Ensembl=ENSMODG00000007536|UniProtKB=K7E435	Integrin beta	ISS	10706722	PubMed	PTHR10082:SF28	INTEGRIN BETA-1
P05915	Opioid proenkephalin pathway	P05994	G-protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00040	Metabotropic glutamate receptor group II pathway	P01052	AC	MOUSE|MGI=MGI=2660854|UniProtKB=Q8C0T9	Adenylate cyclase type 10	ISS	11744988	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P00029	Huntington disease	P00780	Microtubule	DROME|FlyBase=FBgn0003887|UniProtKB=Q24560	Tubulin beta-1 chain	IDA	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	DROME|FlyBase=FBgn0037138|UniProtKB=Q9VNX4	Delta-1-Pyrroline-5-carboxylate dehydrogenase 1, isoform A	IC			PTHR42862:SF1	DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED
P00015	Circadian clock system	P00505	Cry	RAT|RGD=735083|UniProtKB=Q32Q86	Cryptochrome-1	ISS	10217146	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00021	FGF signaling pathway	P00627	ERK1-2	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	20384797	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00056	VEGF signaling pathway	P01409	cPLA2	PANTR|Ensembl=ENSPTRG00000001787|UniProtKB=H2Q0T0	Phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P05918	p38 MAPK pathway	P06031	p38alpha	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00010	B cell activation	P00398	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00586	Gq	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IGI	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00060	Ubiquitin proteasome pathway	P01494	19S proteasome	PANTR|Ensembl=ENSPTRG00000010986|UniProtKB=H2QGB8	Proteasome (Prosome, macropain) 26S subunit, ATPase, 4	ISS			PTHR23073:SF8	26S PROTEASE REGULATORY SUBUNIT 6B
P02738	De novo purine biosynthesis	P02902	ADP reductase	TRYB2|Gene=Tb11.v4.0007|UniProtKB=Q382Q0	Ribonucleoside-diphosphate reductase small chain	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00029	Huntington disease	P00807	Actin	CAEBR|Gene=CBG02162|UniProtKB=A8WS33	Protein CBG02162	ISS	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00010	B cell activation	P00391	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00115	Nicastrin	DROME|FlyBase=FBgn0039234|UniProtKB=Q9VC27	Nicastrin	IDA	10993067	PubMed	PTHR21092:SF0	NICASTRIN
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01332	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01275	P38	BOVIN|Ensembl=ENSBTAG00000030182|UniProtKB=G3X793	Mitogen-activated protein kinase	ISS	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00054	Toll receptor signaling pathway	P01345	IKKalpha	HUMAN|HGNC=1974|UniProtKB=O15111	Inhibitor of nuclear factor kappa-B kinase subunit alpha	ISS	9346484	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00019	Endothelin signaling pathway	P00591	PLCbeta	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00057	Wnt signaling pathway	P01458	Protein Kinase C	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MACMU|Ensembl=ENSMMUG00000015866|UniProtKB=F7C233	Uncharacterized protein	ISS	14570579	PubMed	PTHR21230:SF26	VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1B
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	HUMAN|HGNC=4401|UniProtKB=O14775	Guanine nucleotide-binding protein subunit beta-5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00054	Toll receptor signaling pathway	P01369	MKK1	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00047	PDGF signaling pathway	P01152	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00005	Angiogenesis	P00190	RasGAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	ISS	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00017	DNA replication	P00533	Pol delta	MACMU|Ensembl=ENSMMUG00000021525|UniProtKB=F7FF89	DNA polymerase	ISS	92089082	PubMed	PTHR10322:SF23	DNA POLYMERASE DELTA CATALYTIC SUBUNIT
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	LEIMA|EnsemblGenome=LmjF.35.4010|UniProtKB=Q9GNR4	Protein kinase A catalytic subunit isoform 1	ISS	10553940	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P02788	Xanthine and guanine salvage pathway	P03248	Deoxyguanosine phosphorylase	PANTR|Ensembl=ENSPTRG00000006095|UniProtKB=H2Q7W4	Purine nucleoside phosphorylase	ISS			PTHR11904:SF12	PURINE NUCLEOSIDE PHOSPHORYLASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	MACMU|Ensembl=ENSMMUG00000004886|UniProtKB=F7AGT9	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00057	Wnt signaling pathway	P01432	Beta-Catenin	DANRE|ZFIN=ZDB-GENE-040426-2575|UniProtKB=E7FC99	Uncharacterized protein	ISS			PTHR23315:SF68	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01443	Phospholipase C	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IDA	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00054	Toll receptor signaling pathway	P01369	MKK1	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05734	Synaptic vesicle trafficking	P05774	NSF	HUMAN|HGNC=8016|UniProtKB=P46459	Vesicle-fusing ATPase	IDA	11348590	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00057	Wnt signaling pathway	P01468	APC	HUMAN|HGNC=583|UniProtKB=P25054	Adenomatous polyposis coli protein	IDA	12549854	PubMed	PTHR12607:SF11	ADENOMATOUS POLYPOSIS COLI PROTEIN
P00053	T cell activation	P01307	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	RCA			PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04398	p53 pathway feedback loops 2	P04661	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	14526383	PubMed	PTHR10048:SF14	PI-3 KINASE
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000022936|UniProtKB=F6U709	Uncharacterized protein	ISS	2137198	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IGI	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1718748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01305	Calmodulin	MONDO|Ensembl=ENSMODG00000004410|UniProtKB=F6SV58	Uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF322	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00048	PI3 kinase pathway	P01199	Galpha	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	IC	9166716	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00865	Shc	MOUSE|MGI=MGI=98296|UniProtKB=P98083	SHC-transforming protein 1	ISS	95096035	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00046	Oxidative stress response	P01126	ATF2	MONDO|Ensembl=ENSMODG00000009514|UniProtKB=F7EVK3	Uncharacterized protein	ISS	10207617	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00020	FAS signaling pathway	P00615	JNK	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	TAS	10851062	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MOUSE|MGI=MGI=87909|UniProtKB=P62737	Actin, aortic smooth muscle	IC	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	HUMAN|HGNC=1388|UniProtKB=O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	8386525	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00047	PDGF signaling pathway	P01149	MNK1/2	XENTR|Xenbase=XB-GENE-979969|UniProtKB=Q66JF3	MAP kinase-interacting serine/threonine-protein kinase 1	ISS			PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	CHICK|Ensembl=ENSGALG00000009320|UniProtKB=Q4JIM4	Presenilin-1	IDA	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00019	Endothelin signaling pathway	P00586	Gq	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	ORNAN|Ensembl=ENSOANG00000009269|UniProtKB=F7ES15	Uncharacterized protein	ISS			PTHR19957:SF83	SYNTAXIN-16
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000017387|UniProtKB=E2RLD1	Uncharacterized protein	ISS	12507995	PubMed	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00051	TCA cycle	P01268	Aconitase	EMENI|EnsemblGenome=CADANIAG00003560|UniProtKB=C8VG90	Aconitate hydratase, mitochondrial	ISS	3661614	gi	PTHR43160:SF3	ACONITATE HYDRATASE, MITOCHONDRIAL
P00005	Angiogenesis	P00234	Grb2	CAEEL|WormBase=WBGene00004774|UniProtKB=P29355	Sex muscle abnormal protein 5	ISS			PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00018	EGF receptor signaling pathway	P00539	14-3-3	MACMU|Ensembl=ENSMMUG00000013206|UniProtKB=F6XFG9	14-3-3 protein beta/alpha	ISS	10407019	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	BOVIN|Gene=QARS|UniProtKB=Q3MHH4	Glutamine--tRNA ligase	ISS			PTHR43097:SF4	GLUTAMINE--TRNA LIGASE-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04454	CRF	PANTR|Ensembl=ENSPTRG00000020304|UniProtKB=H2QW88	Uncharacterized protein	ISS	122560	OMIM	PTHR15035:SF9	CORTICOLIBERIN
P00056	VEGF signaling pathway	P01407	Erk	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00561	STAT	MOUSE|MGI=MGI=103062|UniProtKB=P42228	Signal transducer and activator of transcription 4	IGI	94255416	PubMed	PTHR11801:SF19	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 4
P00051	TCA cycle	P01274	Succinyl CoA Synthetase	CHLTR|EnsemblGenome=CT_822|UniProtKB=O84829	Succinyl-CoA ligase [ADP-forming] subunit alpha	ISS	20150255	PubMed	PTHR11117:SF11	SUCCINYL-COA LIGASE  ADP-FORMING  SUBUNIT ALPHA
P05913	Enkephalin release	P05977	G-Protein (s)	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00018	EGF receptor signaling pathway	P00544	c-Cbl	DANRE|ZFIN=ZDB-GENE-041114-207|UniProtKB=F1QI90	Uncharacterized protein	ISS			PTHR23007:SF5	E3 UBIQUITIN-PROTEIN LIGASE CBL
P00057	Wnt signaling pathway	P01429	Axin	CHICK|Gene=AXIN1|UniProtKB=O42400	Axin-1	IDA	9554852	PubMed	PTHR10845:SF11	AXIN-1
P04393	Ras Pathway	P04570	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00981	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00048	PI3 kinase pathway	P01177	P110ACT	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MOUSE|MGI=MGI=102845|UniProtKB=P32299	B2 bradykinin receptor	IDA	12130679	PubMed	PTHR24228:SF25	B2 BRADYKININ RECEPTOR
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00542	EGFR	ORNAN|Ensembl=ENSOANG00000007021|UniProtKB=F7GAV2	Receptor protein-tyrosine kinase	ISS	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P02731	Biotin biosynthesis	P02856	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	AQUAE|EnsemblGenome=aq_170|UniProtKB=O66557	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	ISS			PTHR42684:SF3	ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	MOUSE|MGI=MGI=894297|UniProtKB=O08585	Clathrin light chain A	ISS	9388255	PubMed	PTHR10639:SF1	CLATHRIN LIGHT CHAIN A
P00036	Interleukin signaling pathway	P00977	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	BOVIN|Ensembl=ENSBTAG00000009702|UniProtKB=F1N775	Uncharacterized protein	IC	10938134	PubMed	PTHR13140:SF368	MYOSIN-8
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01167	Ets	RAT|RGD=1310282|UniProtKB=B2RYD8	Ehf protein	ISS	15298723	PubMed	PTHR11849:SF171	ETS HOMOLOGOUS FACTOR
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04570	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	1718748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00021	FGF signaling pathway	P00627	ERK1-2	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05726	2-arachidonoylglycerol biosynthesis	P05736	DGL	CANLF|Ensembl=ENSCAFG00000010161|UniProtKB=F1PA62	Lipoprotein lipase	ISS			PTHR11610:SF3	LIPOPROTEIN LIPASE
P00057	Wnt signaling pathway	P01435	SWI/SNF	MACMU|Ensembl=ENSMMUG00000000829|UniProtKB=F6Q1Z2	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5	ISS	11532957	PubMed	PTHR10799:SF887	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5
P00046	Oxidative stress response	P01131	MKP5	TAKRU|Ensembl=ENSTRUG00000017083|UniProtKB=Q8UW48	Dual specificity protein phosphatase	TAS			PTHR10159:SF45	DUAL SPECIFICITY PROTEIN PHOSPHATASE 6
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00057	Wnt signaling pathway	P01465	Ggamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00049	Parkinson disease	P01242	Casein kinase I	CHLRE|EnsemblGenome=CHLREDRAFT_15736|UniProtKB=Q8W1K7	Serine/threonine protein kinase	IDA	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02783	Tryptophan biosynthesis	P03206	Anthranilate synthase	SYNY3|EnsemblGenome=BAA16689|UniProtKB=P20170	Anthranilate synthase component 1	ISS			PTHR11236:SF9	ANTHRANILATE SYNTHASE COMPONENT 1
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	DANRE|Ensembl=ENSDARG00000070511|UniProtKB=E7F5R2	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF282	GLUTAMATE RECEPTOR-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01162	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00020	FAS signaling pathway	P00620	CytochromeC	BOVIN|Ensembl=ENSBTAG00000012232|UniProtKB=P00125	Cytochrome c1, heme protein, mitochondrial	ISS	9027315	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	MONDO|Ensembl=ENSMODG00000023683|UniProtKB=F6T0L6	Uncharacterized protein (Fragment)	ISS	9700720	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00056	VEGF signaling pathway	P01423	p38MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00626	Spry	HUMAN|HGNC=11270|UniProtKB=O43597	Protein sprouty homolog 2	IGI	12815057	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P00052	TGF-beta signaling pathway	P01275	P38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	TAS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00052	TGF-beta signaling pathway	P01284	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00022	General transcription by RNA polymerase I	P00657	TBP	DANRE|ZFIN=ZDB-GENE-030616-563|UniProtKB=Q7SXL3	TATA-box-binding protein	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00018	EGF receptor signaling pathway	P00545	JNK1-3	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IGI	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00828	Galphai	SCLS1|EnsemblGenome=SS1G_12343|UniProtKB=A7F345	Guanine nucleotide-binding protein alpha subunit	ISS			PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04376	5HT4 type receptor mediated signaling pathway	P04427	5HT4 Receptor	RAT|RGD=2850|UniProtKB=Q62758	5-hydroxytryptamine receptor 4	ISS	15118808	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P00045	Notch signaling pathway	P01108	Nicastrin	HUMAN|HGNC=17091|UniProtKB=Q92542	Nicastrin	TAS	16096062	PubMed	PTHR21092:SF0	NICASTRIN
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IC	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=19218|UniProtKB=Q86YW0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1	ISS	12860966	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P00018	EGF receptor signaling pathway	P00547	PP2A	HUMAN|HGNC=9300|UniProtKB=P62714	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	IGI	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P02759	Pyridoxal-5-phosphate biosynthesis	P03061	Pyridoxine-5-phosphate oxidase	PANTR|Ensembl=ENSPTRG00000009343|UniProtKB=H2QDB2	Pyridoxamine 5'-phosphate oxidase	ISS	9601034	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00059	p53 pathway	P04614	Cyclin B	MOUSE|MGI=MGI=88302|UniProtKB=P24860	G2/mitotic-specific cyclin-B1	ISS	1019642	gi	PTHR10177:SF193	G2/MITOTIC-SPECIFIC CYCLIN-B1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00648	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00025	Hedgehog signaling pathway	P00682	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	MACMU|Ensembl=ENSMMUG00000019999|UniProtKB=F7FNE2	Uncharacterized protein	ISS	11443533	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00006	Apoptosis signaling pathway	P00269	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00640	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IGI	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P06213	DPP signaling pathway	P06280	PDP	DROME|FlyBase=FBgn0029958|UniProtKB=Q9W3Q1	GM14286p	IDA	16510868	PubMed	PTHR13832:SF503	PYRUVATE DEHYDROGENASE  ACETYL-TRANSFERRING  -PHOSPHATASE 1, MITOCHONDRIAL
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	XENTR|Ensembl=ENSXETG00000021375|UniProtKB=F6T423	Uncharacterized protein	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00034	Integrin signalling pathway	P00925	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00025	Hedgehog signaling pathway	P00682	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00810	GAPDH	PSEAE|EnsemblGenome=PA3195|UniProtKB=P27726	Glyceraldehyde-3-phosphate dehydrogenase	IPI			PTHR43148:SF2	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE C-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00752	cGMP-gated ion channel	HUMAN|HGNC=2148|UniProtKB=P29973	cGMP-gated cation channel alpha-1	IDA	12432397	PubMed	PTHR10217:SF387	CYCLIC NUCLEOTIDE-GATED CHANNEL ROD PHOTORECEPTOR SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01162	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00049	Parkinson disease	P01236	Casein kinase II	BRAFL|Gene=BRAFLDRAFT_113587|UniProtKB=C3ZBE3	Putative uncharacterized protein	ISS	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	DANRE|ZFIN=ZDB-GENE-010319-1|UniProtKB=B8JMI2	Uncharacterized protein	TAS	10409711	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P00029	Huntington disease	P00807	Actin	PHYPA|Gene=PHYPADRAFT_109052|UniProtKB=A9TZ58	Actin 5	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	MACMU|Ensembl=ENSMMUG00000010678|UniProtKB=F7AXI7	Uncharacterized protein	ISS	1706187	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DANRE|ZFIN=ZDB-GENE-030131-7596|UniProtKB=Q6PBN9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF26	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT GAMMA-T1
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	HUMAN|HGNC=16767|UniProtKB=Q8TCU5	Glutamate receptor ionotropic, NMDA 3A	ISS	14698601	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00029	Huntington disease	P00780	Microtubule	RAT|RGD=1588452|UniProtKB=P85108	Tubulin beta-2A chain	IDA	12932731	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P00021	FGF signaling pathway	P00643	Raf-1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00629	PP2A	CAEEL|WormBase=WBGene00006352|UniProtKB=G5EDR3	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B	IGI	12019228	PubMed	PTHR11871:SF0	PROTEIN PHOSPHATASE PP2A 55 KDA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01457	GBeta	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	CHICK|Ensembl=ENSGALG00000013981|UniProtKB=Q9YGV8	TATA box-binding protein-like protein 1	ISS	10454611	PubMed	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00019	Endothelin signaling pathway	P00572	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00048	PI3 kinase pathway	P01181	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00034	Integrin signalling pathway	P00923	Arf1	MACMU|Ensembl=ENSMMUG00000002792|UniProtKB=F7H235	ADP-ribosylation factor 1	ISS	11752622	PubMed	PTHR11711:SF294	ADP-RIBOSYLATION FACTOR 3
P00047	PDGF signaling pathway	P01154	Ras	DROME|FlyBase=FBgn0003205|UniProtKB=P08646	Ras-like protein 1	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MOUSE|MGI=MGI=87905|UniProtKB=P68033	Actin, alpha cardiac muscle 1	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	ANOGA|EnsemblGenome=AGAP010172|UniProtKB=Q7PD38	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	3045562	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00019	Endothelin signaling pathway	P00566	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01168	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	1171954	gi	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00046	Oxidative stress response	P01129	JNK1/2	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00049	Parkinson disease	P01238	14-3-3	HUMAN|HGNC=12852|UniProtKB=P61981	14-3-3 protein gamma	IDA	10407019	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MACMU|Ensembl=ENSMMUG00000004817|UniProtKB=F6QJP0	Histamine H1 receptor	ISS			PTHR43914:SF2	HISTAMINE H1 RECEPTOR
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95814|UniProtKB=Q60934	Glutamate receptor ionotropic, kainate 1	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00036	Interleukin signaling pathway	P00981	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00021	FGF signaling pathway	P00645	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	14564011	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MONDO|Ensembl=ENSMODG00000001775|UniProtKB=F6WJB1	Uncharacterized protein	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00048	PI3 kinase pathway	P01179	PKB	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04542	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00020	FAS signaling pathway	P00615	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	TAS	10514528	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	ENTHI|EnsemblGenome=EHI_024230|UniProtKB=C4M0H9	Cysteine synthase A, putative	ISS			PTHR10314:SF131	CYSTEINE SYNTHASE 1
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	CHICK|Ensembl=ENSGALG00000009320|UniProtKB=Q4JIM4	Presenilin-1	TAS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00020	FAS signaling pathway	P00594	Caspase8	PANTR|Ensembl=ENSPTRG00000012798|UniProtKB=H2R695	CASP8 and FADD-like apoptosis regulator	ISS	9217161	PubMed	PTHR10454:SF8	CASP8 AND FADD-LIKE APOPTOSIS REGULATOR
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	TAKRU|Ensembl=ENSTRUG00000015938|UniProtKB=H2UUX5	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00865	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	10982827	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00048	PI3 kinase pathway	P01188	Gbetagamma	DICDI|dictyBase=DDB_G0277143|UniProtKB=P36408	Guanine nucleotide-binding protein subunit beta	IC	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00059	p53 pathway	G04694	p110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	G01581	BAX	MACMU|Ensembl=ENSMMUG00000003907|UniProtKB=F6ZV96	Apoptosis regulator BAX isoform alpha	ISS	8358790	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P00057	Wnt signaling pathway	P01438	PP2A	PANTR|Ensembl=ENSPTRG00000001958|UniProtKB=H2Q137	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00224	PDGF	CHICK|Ensembl=ENSGALG00000003642|UniProtKB=F1NJJ2	Uncharacterized protein	ISS			PTHR11633:SF3	PLATELET-DERIVED GROWTH FACTOR SUBUNIT A
P00006	Apoptosis signaling pathway	P00310	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000014828|UniProtKB=F1N1E0	Uncharacterized protein	ISS	14507926	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00029	Huntington disease	P00810	GAPDH	DROME|FlyBase=FBgn0034173|UniProtKB=Q7JY07	Glyceraldehyde-3-phosphate dehydrogenase	IPI			PTHR10836:SF52	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	22081553	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00021	FGF signaling pathway	P00629	PP2A	DICPU|Gene=DICPUDRAFT_91511|UniProtKB=F0ZDJ1	Serine/threonine-protein phosphatase	ISS	99379588	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00046	Oxidative stress response	P01123	Bcl-2	RAT|RGD=2199|UniProtKB=P49950	Apoptosis regulator Bcl-2	TAS	2250705	PubMed	PTHR11256:SF11	APOPTOSIS REGULATOR BCL-2
P00049	Parkinson disease	P01230	Src kinase	HUMAN|HGNC=4037|UniProtKB=P06241	Tyrosine-protein kinase Fyn	IDA	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00059	p53 pathway	P01486	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02787	Vitamin B6 metabolism	P03244	Pyridoxal kinase	MACMU|Ensembl=ENSMMUG00000012300|UniProtKB=F7DLS4	Uncharacterized protein	ISS	9099727	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P00025	Hedgehog signaling pathway	P00697	Sap18	DROME|FlyBase=FBgn0024491|UniProtKB=Q9VEX9	Histone deacetylase complex subunit SAP18	ISS			PTHR13082:SF0	HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18
P00049	Parkinson disease	P01226	CDCrel-1	PANTR|Ensembl=ENSPTRG00000009455|UniProtKB=H2QDJ3	Uncharacterized protein	ISS			PTHR18884:SF71	SEPTIN-4
P00006	Apoptosis signaling pathway	P00318	PKCs	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00586	Gq	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	DEIRA|EnsemblGenome=DR_0460|UniProtKB=Q9RX55	Acetyl-CoA synthase	ISS			PTHR24095:SF14	ACETYL-COENZYME A SYNTHETASE 1
P00054	Toll receptor signaling pathway	P01369	MKK1	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00018	EGF receptor signaling pathway	P00547	PP2A	SCHMA|EnsemblGenome=Smp_165490|UniProtKB=C1LZY9	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MACMU|Ensembl=ENSMMUG00000014807|UniProtKB=F6W548	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00029	Huntington disease	P00807	Actin	PANTR|Ensembl=ENSPTRG00000009762|UniProtKB=H2QE24	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00010	B cell activation	P00383	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	IDA	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00012	Cadherin signaling pathway	P00474	Wnt	MONDO|Ensembl=ENSMODG00000013820|UniProtKB=F6SF10	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P00006	Apoptosis signaling pathway	P00282	IGFR2	RAT|RGD=2871|UniProtKB=G3V824	Insulin-like growth factor 2 receptor, isoform CRA_b	IDA	11081635	PubMed	PTHR15071:SF17	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
P00005	Angiogenesis	P00223	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00639	Shc	BOVIN|Ensembl=ENSBTAG00000019838|UniProtKB=Q0IIE2	SHC-transforming protein 1	ISS	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00048	PI3 kinase pathway	P01177	P110ACT	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01443	Phospholipase C	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=97255|UniProtKB=Q02566	Myosin-6	IC	89264452	PubMed	PTHR13140:SF721	MYOSIN-6
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P02728	Arginine biosynthesis	P02840	Argininosuccinate synthase	SCHPO|PomBase=SPBC428.05c|UniProtKB=O94354	Argininosuccinate synthase	ISS			PTHR11587:SF2	ARGININOSUCCINATE SYNTHASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	BOVIN|Gene=CLTC|UniProtKB=P49951	Clathrin heavy chain 1	IDA	9388255	PubMed	PTHR10292:SF7	CLATHRIN HEAVY CHAIN 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DANRE|ZFIN=ZDB-GENE-000329-1|UniProtKB=Q7ZVI7	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00034	Integrin signalling pathway	P00907	ERK	BOVIN|Ensembl=ENSBTAG00000005865|UniProtKB=G5E577	Uncharacterized protein	ISS	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P04393	Ras Pathway	P04578	Rho	HUMAN|HGNC=669|UniProtKB=P08134	Rho-related GTP-binding protein RhoC	IDA	12090470	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00005	Angiogenesis	P00206	Wnt	TAKRU|Ensembl=ENSTRUG00000017138|UniProtKB=H2V3X9	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00053	T cell activation	P01332	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	IDA	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02744	Fructose galactose metabolism	P02966	Hexokinase	PANTR|Ensembl=ENSPTRG00000002570|UniProtKB=H2Q205	Uncharacterized protein	RCA			PTHR19443:SF28	HEXOKINASE HKDC1-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	DANRE|ZFIN=ZDB-GENE-070705-74|UniProtKB=B8A569	Uncharacterized protein	IC			PTHR13140:SF676	MYOSIN, HEAVY POLYPEPTIDE 2, FAST MUSCLE SPECIFIC
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	PANTR|Ensembl=ENSPTRG00000020930|UniProtKB=H2QX95	Uncharacterized protein	ISS	9388255	PubMed	PTHR10639:SF1	CLATHRIN LIGHT CHAIN A
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	CANLF|Ensembl=ENSCAFG00000018170|UniProtKB=E2RPM8	Tyrosine-protein kinase receptor	ISS	14500580	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00053	T cell activation	P01305	Calmodulin	ARATH|TAIR=AT3G43810|UniProtKB=P59220	Calmodulin-7	ISS	7514101	PubMed	PTHR23050:SF250	CALMODULIN-7
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01237	Complex I	THEMA|EnsemblGenome=TM_1424|UniProtKB=Q9S5X7	Fe-hydrogenase, subunit gamma	TAS			PTHR43342:SF1	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00313	IKK	CANLF|Ensembl=ENSCAFG00000005526|UniProtKB=E2RKR0	Uncharacterized protein	ISS	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000000365|UniProtKB=F6R9F4	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=1336171|UniProtKB=Q9DAS9	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00053	T cell activation	P01300	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	RCA	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CAEEL|WormBase=WBGene00015478|UniProtKB=Q11179	Putative serine/threonine-protein kinase C05D10.2	IDA	10851062	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00318	PKCs	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IDA	3755548	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P02748	Isoleucine biosynthesis	P02994	Branched chain amino acid aminotransferase	BOVIN|Ensembl=ENSBTAG00000009172|UniProtKB=Q5EA40	Branched-chain-amino-acid aminotransferase, mitochondrial	ISS			PTHR11825:SF39	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	BACSU|EnsemblGenome=BSU37790|UniProtKB=P39633	Catabolic NAD-specific glutamate dehydrogenase RocG	ISS			PTHR11606:SF13	GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	ISS	11535291	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IPI	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_127488|UniProtKB=C3XYC7	Putative uncharacterized protein	IDA	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=619760|UniProtKB=P58365	Cadherin-23	IDA	8120095	PubMed	PTHR43956:SF3	CADHERIN-23
P00056	VEGF signaling pathway	P01417	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P04395	Vasopressin synthesis	P04589	Signal Peptidase	DROME|FlyBase=FBgn0030306|UniProtKB=Q9VYY2	Signal peptidase complex subunit 2	IC	7788527	PubMed	PTHR13085:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 2
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04384	Gamma-aminobutyric acid synthesis	P04481	Succinic semialdehyde dehydrogenase	ANOGA|EnsemblGenome=AGAP003165|UniProtKB=Q7QBI1	AGAP003165-PA	IC	12891648	PubMed	PTHR43353:SF5	SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL
P06212	DPP-SCW signaling pathway	P06269	LACK	DROME|FlyBase=FBgn0029006|UniProtKB=Q9V853	E3 ubiquitin-protein ligase Smurf1	IEA	11252892	PubMed	PTHR11254:SF395	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P00019	Endothelin signaling pathway	P00566	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00398	IP3R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00036	Interleukin signaling pathway	P00990	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IC	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02756	N-acetylglucosamine metabolism	P03041	Glucosamine-6-phosphate deaminase	DROME|FlyBase=FBgn0031717|UniProtKB=Q9VMP9	Glucosamine-6-phosphate isomerase	ISS			PTHR11280:SF17	GLUCOSAMINE-6-PHOSPHATE ISOMERASE
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00053	T cell activation	P01298	NFkappaB	RAT|RGD=1307189|UniProtKB=Q5U2Z4	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	ISS	20151924	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00047	PDGF signaling pathway	P01162	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00007	Axon guidance mediated by semaphorins	P00341	Rho	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	ISS	15668138	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00060	Ubiquitin proteasome pathway	P01491	E2	MONDO|Ensembl=ENSMODG00000020556|UniProtKB=F7AQ16	Uncharacterized protein	ISS			PTHR44020:SF2	UBIQUITIN-CONJUGATING ENZYME E2 K
P00037	Ionotropic glutamate receptor pathway	P01015	Glu4	PANTR|Ensembl=ENSPTRG00000004233|UniProtKB=H2Q4N9	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	RCA	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00790	beta-Tubulin	HUMAN|HGNC=20772|UniProtKB=Q13509	Tubulin beta-3 chain	TAS	9454836	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P04393	Ras Pathway	P04571	Tiam1	MACMU|Ensembl=ENSMMUG00000019571|UniProtKB=F7BGM6	T-lymphoma invasion and metastasis-inducing protein 1	ISS	11130063	PubMed	PTHR22826:SF88	T-LYMPHOMA INVASION AND METASTASIS-INDUCING PROTEIN 1
P05918	p38 MAPK pathway	P06036	MKK3	ORNAN|Ensembl=ENSOANG00000007732|UniProtKB=F6PXH5	Uncharacterized protein (Fragment)	ISS	97059154	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	ARATH|TAIR=AT3G03940|UniProtKB=Q9SQR8	Protein kinase family protein	IDA	10617630	PubMed	PTHR11909:SF131	CASEIN KINASE-LIKE PROTEIN-RELATED
P00056	VEGF signaling pathway	P01411	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	XENTR|Xenbase=XB-GENE-493937|UniProtKB=Q5M8T9	Actin, alpha 2, smooth muscle, aorta	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	RAT|RGD=62030|UniProtKB=P02564	Myosin-7	IEP	10938134	PubMed	PTHR13140:SF344	MYOSIN-7
P00029	Huntington disease	P00790	beta-Tubulin	PHANO|Gene=SNOG_06790|UniProtKB=P41799	Tubulin beta chain	TAS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P02721	ATP synthesis	P02791	F1 alpha	RAT|RGD=619993|UniProtKB=P15999	ATP synthase subunit alpha, mitochondrial	ISS	11479684	PubMed	PTHR43089:SF3	ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL
P00010	B cell activation	P00385	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00036	Interleukin signaling pathway	P00977	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00021	FGF signaling pathway	P00632	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	HUMAN|HGNC=9508|UniProtKB=P49768	Presenilin-1	TAS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00036	Interleukin signaling pathway	P00994	FKHRL1	RAT|RGD=1309196|UniProtKB=D3ZBQ1	Forkhead box O3a (Predicted)	ISS	15031210	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01199	Galpha	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00049	Parkinson disease	P01219	SAPK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00057	Wnt signaling pathway	P01434	sFRP	BOVIN|Ensembl=ENSBTAG00000018563|UniProtKB=Q3SX29	Secreted frizzled-related protein 2	ISS	9096311	PubMed	PTHR11309:SF45	SECRETED FRIZZLED-RELATED PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g169611|UniProtKB=A7SEB1	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=97438|UniProtKB=P32300	Delta-type opioid receptor	IDA	11259487	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	HUMAN|HGNC=10647|UniProtKB=P78423	Fractalkine	IDA	11960641	PubMed	PTHR12015:SF92	FRACTALKINE
P02770	Pyridoxal phosphate salvage pathway	P03123	Pyridoxine-5-phosphate oxidase	MACMU|Ensembl=ENSMMUG00000003325|UniProtKB=F7EHD9	Pyridoxine-5'-phosphate oxidase	ISS	15182361	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00010	B cell activation	P00398	IP3R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	TAS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04372	5-Hydroxytryptamine degredation	P04401	Monoamine Oxidase	BOVIN|Gene=MAOB|UniProtKB=P56560	Amine oxidase [flavin-containing] B	ISS	8602220	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	NEUCR|EnsemblGenome=EFNCRG00000003612|UniProtKB=P05220	Tubulin beta chain	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00217	STAT3	MACMU|Ensembl=ENSMMUG00000010707|UniProtKB=F7G8G5	Signal transducer and activator of transcription	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00023	General transcription regulation	P00664	TFIIH complex	HUMAN|HGNC=4657|UniProtKB=Q13889	General transcription factor IIH subunit 3	ISS			PTHR12831:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3
P00036	Interleukin signaling pathway	P00996	STAT	MACMU|Ensembl=ENSMMUG00000010705|UniProtKB=F7G8V4	Signal transducer and activator of transcription	ISS	95188889	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P06959	CCKR signaling map	P07065	PAK1	HUMAN|HGNC=8590|UniProtKB=Q13153	Serine/threonine-protein kinase PAK 1	RCA	18565785	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00004	Alzheimer disease-presenilin pathway	P00144	Ire-1	MOUSE|MGI=MGI=1349436|UniProtKB=Q9Z2E3	Serine/threonine-protein kinase/endoribonuclease IRE2	IDA	10619423	PubMed	PTHR13954:SF15	SERINE/THREONINE-PROTEIN KINASE/ENDORIBONUCLEASE IRE2
P00049	Parkinson disease	P01219	SAPK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00029	Huntington disease	G01529	Proline oxidase	RAT|RGD=1306761|UniProtKB=Q2V057	Probable proline dehydrogenase 2	ISS			PTHR13914:SF5	PROLINE DEHYDROGENASE 2-RELATED
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02748	Isoleucine biosynthesis	P02997	Acetolactate synthase	SULSO|EnsemblGenome=SSO2774|UniProtKB=Q97V62	Acetolactate synthase large subunit homolog (IlvB-4)	ISS			PTHR18968:SF13	ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL
P04393	Ras Pathway	P04553	PAK	CHICK|Ensembl=ENSGALG00000000681|UniProtKB=E1C3P6	Uncharacterized protein	ISS	14580336	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00057	Wnt signaling pathway	P01457	GBeta	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00019	Endothelin signaling pathway	P00587	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00029	Huntington disease	P00780	Microtubule	SCLS1|EnsemblGenome=SS1G_04652|UniProtKB=A7EH60	Beta tubulin	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT1G18150|UniProtKB=Q9LM33	Mitogen-activated protein kinase 8	ISS	10851062	PubMed	PTHR24055:SF246	MITOGEN-ACTIVATED PROTEIN KINASE 15-RELATED
P00007	Axon guidance mediated by semaphorins	P00331	PAK	BOVIN|Ensembl=ENSBTAG00000010191|UniProtKB=Q08E52	Serine/threonine-protein kinase PAK 1	ISS	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00054	Toll receptor signaling pathway	P01356	ERK2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=97441|UniProtKB=P42866	Mu-type opioid receptor	IDA	11259498	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00056	VEGF signaling pathway	P01423	p38MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000018853|UniProtKB=F6XSK8	Uncharacterized protein	ISS	12181435	PubMed	PTHR24229:SF42	SOMATOSTATIN RECEPTOR TYPE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00514	MLCK	PANTR|Ensembl=ENSPTRG00000015307|UniProtKB=H2R459	Uncharacterized protein	ISS	600922	OMIM	PTHR45480:SF1	MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE
P00016	Cytoskeletal regulation by Rho GTPase	P00507	Rho	HUMAN|HGNC=669|UniProtKB=P08134	Rho-related GTP-binding protein RhoC	ISS	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04393	Ras Pathway	P04570	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00580	ET-RA/B	HUMAN|HGNC=3180|UniProtKB=P24530	Endothelin B receptor	IGI	12355085	PubMed	PTHR24243:SF30	ENDOTHELIN B RECEPTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05917	Opioid proopiomelanocortin pathway	P06008	ACTH	MONDO|Ensembl=ENSMODG00000015853|UniProtKB=Q95J84	Proopiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00018	EGF receptor signaling pathway	P00562	p38	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	IGI	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CAEEL|WormBase=WBGene00004036|UniProtKB=G5EFI8	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00048	PI3 kinase pathway	P01194	S6K	HUMAN|HGNC=10437|UniProtKB=Q9UBS0	Ribosomal protein S6 kinase beta-2	ISS	6755374	gi	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P02771	Pyrimidine Metabolism	P03129	Aminotransferase	CAEEL|WormBase=WBGene00001794|UniProtKB=Q21217	Probable 4-aminobutyrate aminotransferase, mitochondrial	IMP	137150	OMIM	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00059	p53 pathway	G04701	PML	PANTR|Ensembl=ENSPTRG00000007266|UniProtKB=Q15JE1	Promyelocytic leukemia	ISS	14992722	PubMed	PTHR45211:SF1	PROTEIN PML
P00005	Angiogenesis	P00195	APC	XENTR|Xenbase=XB-GENE-480855|UniProtKB=F6XK08	Uncharacterized protein (Fragment)	ISS	8259518	PubMed	PTHR12607:SF11	ADENOMATOUS POLYPOSIS COLI PROTEIN
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P02750	Lipoate_biosynthesis	P03004	Lipoate synthase	DROME|FlyBase=FBgn0029158|UniProtKB=Q7JQW6	Lipoyl synthase, mitochondrial	ISS			PTHR10949:SF0	LIPOYL SYNTHASE, MITOCHONDRIAL
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CANLF|Ensembl=ENSCAFG00000012181|UniProtKB=F2Z4N7	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04393	Ras Pathway	P04566	Stat 1/3	CHICK|Ensembl=ENSGALG00000003267|UniProtKB=Q6DV79	Signal transducer and activator of transcription 3	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P05917	Opioid proopiomelanocortin pathway	P06011	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00053	T cell activation	P01332	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01192	p110	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P06959	CCKR signaling map	P07086	PLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	RCA	10441493	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P05731	GABA-B receptor II signaling	P05752	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01150	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00011	Blood coagulation	P00410	GP IIb	RAT|RGD=1596428|UniProtKB=D3ZAC0	Protein Itga2b	ISS	3487386	PubMed	PTHR23220:SF73	INTEGRIN ALPHA-IIB
P05913	Enkephalin release	P05974	G-Protein (i)	XENTR|Xenbase=XB-GENE-6050844|UniProtKB=F6WNJ9	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00053	T cell activation	P01300	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00053	T cell activation	P01332	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00051	TCA cycle	P01270	Malate Dehydrogenase	ARATH|TAIR=AT5G43330|UniProtKB=P57106	Malate dehydrogenase, cytoplasmic 2	ISS	15620222	PubMed	PTHR23382:SF3	MALATE DEHYDROGENASE, CYTOPLASMIC
P02788	Xanthine and guanine salvage pathway	P03245	Guanine phosphoribosyl transferase	PANTR|Ensembl=ENSPTRG00000002366|UniProtKB=H2R333	Phosphoribosyl transferase domain containing 1	ISS			PTHR43340:SF5	PHOSPHORIBOSYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	XENTR|Xenbase=XB-GENE-963560|UniProtKB=Q0VFC4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00049	Parkinson disease	P01212	p38 MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02738	De novo purine biosynthesis	P02908	Phosphoribosylamine glycine ligase	PSEAE|EnsemblGenome=PA0944|UniProtKB=Q9I514	Phosphoribosylglycinamide formyltransferase	ISS			PTHR43369:SF2	PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	DANRE|ZFIN=ZDB-GENE-020125-5|UniProtKB=A2CG69	Uncharacterized protein	ISS	20112749	PubMed	PTHR18966:SF356	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IPI	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00012	Cadherin signaling pathway	P00471	Cadherin	BOVIN|Ensembl=ENSBTAG00000005672|UniProtKB=F1N416	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF311	CADHERIN-22
P02768	Proline biosynthesis	P03114	Glutamyl kinase	METAC|EnsemblGenome=MA_4101|UniProtKB=Q9HHA0	Glutamate 5-kinase	ISS			PTHR43654:SF3	GLUTAMATE 5-KINASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02747	Histidine biosynthesis	P02992	Imidazol glycerol phosphate synthase	SCHPO|PomBase=SPBC418.01c|UniProtKB=O94303	Imidazole glycerol phosphate synthase hisHF	ISS			PTHR21235:SF2	IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF
P00056	VEGF signaling pathway	P01425	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04570	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	PANTR|Ensembl=ENSPTRG00000013189|UniProtKB=H2QJV1	Uncharacterized protein	ISS	1706187	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	RCA	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	9332390	PubMed	PTHR10202:SF13	PRESENILIN-2
P00018	EGF receptor signaling pathway	P00556	PLCgamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IGI	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	DROME|FlyBase=FBgn0004509|UniProtKB=P26016	Furin-like protease 1, isoforms 1/1-X/2	IDA	10956649	PubMed	PTHR42884:SF3	FURIN-LIKE PROTEASE 1, ISOFORMS 1/1-X/2
P00048	PI3 kinase pathway	P01181	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01444	Wnt	XENTR|Ensembl=ENSXETG00000024231|UniProtKB=F6TCQ4	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	MOUSE|MGI=MGI=1339984|UniProtKB=Q8CIN4	Serine/threonine-protein kinase PAK 2	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PLAF7|EnsemblGenome=PF10_0084|UniProtKB=Q7KQL5	Tubulin beta chain	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00014	Cholesterol biosynthesis	P00498	Hydroxymethyl glutaryl CoA synthase	HUMAN|HGNC=5007|UniProtKB=Q01581	Hydroxymethylglutaryl-CoA synthase, cytoplasmic	ISS	600234	OMIM	PTHR43323:SF4	HYDROXYMETHYLGLUTARYL-COA SYNTHASE, CYTOPLASMIC
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	CANLF|Gene=HTR2C|UniProtKB=Q60F97	5-hydroxytryptamine receptor 2C	ISS	12441358	PubMed	PTHR24247:SF32	5-HYDROXYTRYPTAMINE RECEPTOR 2C
P00018	EGF receptor signaling pathway	P00551	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DANRE|ZFIN=ZDB-GENE-030131-55|UniProtKB=Q6XNL8	Actin	ISS	10974003	PubMed	PTHR11937:SF263	ACTIN
P00011	Blood coagulation	P00432	FV	BOVIN|Gene=F5|UniProtKB=Q28107	Coagulation factor V	ISS	2493324	gi	PTHR45199:SF1	COAGULATION FACTOR V
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00470	F-actin	DICDI|dictyBase=DDB_G0268744|UniProtKB=Q55EU6	Putative actin-23	IC	11889126	PubMed	PTHR11937:SF154	ACTIN-17-RELATED
P00049	Parkinson disease	P01212	p38 MAPK	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	NAS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00012	Cadherin signaling pathway	P00470	F-actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347736|UniProtKB=E9FRT1	Muscle-specific actin	ISS	11889126	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00848	Grb	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8235613	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00053	T cell activation	P01319	PAK	CHICK|Ensembl=ENSGALG00000008058|UniProtKB=F1N8W8	Uncharacterized protein	ISS	11259591	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00036	Interleukin signaling pathway	P00983	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	RCA	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	P01471	alpha-catenin	RAT|RGD=1311434|UniProtKB=D4A739	Catenin (Cadherin associated protein), alpha-like 1 (Predicted)	ISS	9362521	PubMed	PTHR18914:SF8	ALPHA-CATULIN
P04393	Ras Pathway	P04548	ATF2	BOVIN|Ensembl=ENSBTAG00000002295|UniProtKB=F1N177	Uncharacterized protein	ISS	10487205	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P06959	CCKR signaling map	P07090	MAPK8-10	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	RCA	8621433	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	CANLF|Ensembl=ENSCAFG00000000557|UniProtKB=J9P9W3	Uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF151	CASEIN KINASE I ISOFORM GAMMA-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	STRPU|EnsemblGenome=SPU_012329|UniProtKB=W4Y9B6	Uncharacterized protein	ISS			PTHR19957:SF41	SYNTAXIN-1A
P00045	Notch signaling pathway	P01120	NIcs	HUMAN|HGNC=7883|UniProtKB=Q9UM47	Neurogenic locus notch homolog protein 3	IC	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	PANTR|Ensembl=ENSPTRG00000020403|UniProtKB=H2QWE3	Matrix metallopeptidase 16 (Membrane-inserted)	ISS	12834808	PubMed	PTHR10201:SF26	MATRIX METALLOPROTEINASE-16
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IC	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00059	p53 pathway	G01581	BAX	BOVIN|Ensembl=ENSBTAG00000013340|UniProtKB=O02703	Apoptosis regulator BAX	ISS	11099028	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P00006	Apoptosis signaling pathway	P00321	HSP70	ARATH|TAIR=AT5G42020|UniProtKB=Q39043	Mediator of RNA polymerase II transcription subunit 37f	ISS	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P02768	Proline biosynthesis	P03112	Glutamate semialdehyde dehydrogenase	MYCTU|EnsemblGenome=Rv2427c|UniProtKB=P9WHV1	Gamma-glutamyl phosphate reductase	ISS			PTHR11063:SF8	DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE
P00021	FGF signaling pathway	P00644	p38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01444	Wnt	MACMU|Ensembl=ENSMMUG00000020810|UniProtKB=F7H7P6	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF84	PROTEIN WNT-9B
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00036	Interleukin signaling pathway	P00983	Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	IC	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BOVIN|Ensembl=ENSBTAG00000015364|UniProtKB=E1BEN9	Protein Wnt	ISS	14644163	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IDA			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	TAS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MACMU|Ensembl=ENSMMUG00000020084|UniProtKB=F7GP56	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF427	MYOSIN-3
P00046	Oxidative stress response	P01122	TRX	EMENI|EnsemblGenome=CADANIAG00002566|UniProtKB=P29429	Thioredoxin	ISS			PTHR10438:SF360	THIOREDOXIN H9-RELATED
P00053	T cell activation	P01294	NFAT	RAT|RGD=1307690|UniProtKB=D4A0I8	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (Predicted), isoform CRA_b	ISS	9133421	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P04393	Ras Pathway	P04574	PLD	HUMAN|HGNC=9068|UniProtKB=O14939	Phospholipase D2	IDA	9538008	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	DROME|FlyBase=FBgn0052305|UniProtKB=Q8IRF5	Uncharacterized protein	ISS			PTHR11920:SF338	ACXA, ISOFORM A-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	IDA	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	MOUSE|MGI=MGI=1913670|UniProtKB=Q80UW8	DNA-directed RNA polymerases I, II, and III subunit RPABC1	ISS			PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P00010	B cell activation	P00373	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IGI	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	PYRAE|EnsemblGenome=PAE0794|UniProtKB=Q8ZYG2	Cytidine deaminase	ISS			PTHR11644:SF2	CYTIDINE DEAMINASE
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	PYRAE|EnsemblGenome=PAE3025|UniProtKB=Q8ZTZ0	Glutamine--fructose-6-phosphate aminotransferase [isomerizing]	ISS			PTHR10937:SF0	GH12731P-RELATED
P00056	VEGF signaling pathway	P01425	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00015	Circadian clock system	P00504	Per	DANRE|ZFIN=ZDB-GENE-040419-1|UniProtKB=B3DK47	Period homolog 1b (Drosophila)	ISS	15763996	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P00036	Interleukin signaling pathway	P00981	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DANRE|ZFIN=ZDB-GENE-041210-195|UniProtKB=F1R506	Protein kinase C	ISS	11880265	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04392	P53 pathway feedback loops 1	P04539	p53	MOUSE|MGI=MGI=1330810|UniProtKB=O88898	Tumor protein 63	TAS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	MONDO|Ensembl=ENSMODG00000003969|UniProtKB=F7FMF5	Uncharacterized protein	ISS			PTHR10937:SF10	GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE  ISOMERIZING  2
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04531	Oxytocin Receptor	MACMU|Ensembl=ENSMMUG00000009703|UniProtKB=P56494	Oxytocin receptor	ISS	11006161	PubMed	PTHR24241:SF19	OXYTOCIN RECEPTOR
P06212	DPP-SCW signaling pathway	P06267	TKV	DROME|FlyBase=FBgn0003716|UniProtKB=Q9VMT1	Receptor protein serine/threonine kinase	TAS	9395284	PubMed	PTHR23255:SF68	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00048	PI3 kinase pathway	P01192	p110	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00034	Integrin signalling pathway	P00931	Integrin beta	RAT|RGD=2929|UniProtKB=G3V7M2	Integrin beta	ISS	3487386	PubMed	PTHR10082:SF36	INTEGRIN BETA-7
P00048	PI3 kinase pathway	P01196	PDK1	CAEEL|WormBase=WBGene00003965|UniProtKB=Q9Y1J3	3-phosphoinositide-dependent protein kinase 1	IGI	10364160	PubMed	PTHR24356:SF309	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Gene=HTR1D|UniProtKB=P11614	5-hydroxytryptamine receptor 1D	IDA	14645495	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00049	Parkinson disease	P01238	14-3-3	MACMU|Ensembl=ENSMMUG00000004125|UniProtKB=F6XLR8	14-3-3 protein gamma	ISS	99360936	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00046	Oxidative stress response	P01132	c-jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	P17325	SPACC	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00048	PI3 kinase pathway	P01192	p110	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	8925912	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	HUMAN|HGNC=10430|UniProtKB=Q15418	Ribosomal protein S6 kinase alpha-1	ISS	7688567	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00034	Integrin signalling pathway	P00948	Rho	HUMAN|HGNC=667|UniProtKB=P61586	Transforming protein RhoA	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00009	Axon guidance mediated by netrin	P00363	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	BOVIN|Ensembl=ENSBTAG00000047202|UniProtKB=G3N3K3	Uncharacterized protein	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00056	VEGF signaling pathway	P01423	p38MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00568	PKC	TAKRU|Ensembl=ENSTRUG00000016241|UniProtKB=H2UX35	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF305	PROTEIN KINASE C
P00048	PI3 kinase pathway	P01192	p110	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00019	Endothelin signaling pathway	P00591	PLCbeta	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00045	Notch signaling pathway	P01114	Ntm	HUMAN|HGNC=7881|UniProtKB=P46531	Neurogenic locus notch homolog protein 1	IGI	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	CANLF|Ensembl=ENSCAFG00000024151|UniProtKB=E2R795	Tyrosine-protein kinase receptor	ISS	11182407	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DANRE|ZFIN=ZDB-GENE-030131-6503|UniProtKB=Q7ZUC5	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF297	PROTEIN KINASE C DELTA TYPE
P04393	Ras Pathway	P04556	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00059	p53 pathway	P01480	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00053	T cell activation	P01322	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MACMU|Ensembl=ENSMMUG00000010046|UniProtKB=F6TFK0	Uncharacterized protein	ISS	10048442	gi	PTHR24230:SF8	LEUKOTRIENE B4 RECEPTOR 2
P00019	Endothelin signaling pathway	P00568	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IGI	10395542	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00034	Integrin signalling pathway	P00951	Jnk	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	IDA	97102675	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00029	Huntington disease	P00780	Microtubule	CHICK|Ensembl=ENSGALG00000008586|UniProtKB=F1NYB1	Uncharacterized protein	IDA	12932731	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00007	Axon guidance mediated by semaphorins	P00340	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	10891487	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00010	B cell activation	P00373	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P02777	Succinate to proprionate conversion	P03163	Methylmalonyl-CoA decarboxylase	MOUSE|MGI=MGI=1277169|UniProtKB=Q9D9V3	Ethylmalonyl-CoA decarboxylase	RCA			PTHR11941:SF27	ETHYLMALONYL-COA DECARBOXYLASE
P00029	Huntington disease	P00811	Arp2/3 complex	PANTR|Ensembl=ENSPTRG00000019449|UniProtKB=H2QV01	Actin related protein 2/3 complex, subunit 1B, 41kDa	ISS	12932731	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	CHICK|Gene=PSEN2|UniProtKB=Q90X07	Presenilin-2	TAS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00012	Cadherin signaling pathway	P00466	EGFR	PANTR|Ensembl=ENSPTRG00000012883|UniProtKB=H2QJC5	Receptor protein-tyrosine kinase	ISS	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00052	TGF-beta signaling pathway	P01275	P38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	TAS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DROME|FlyBase=FBgn0030011|UniProtKB=Q9W3J1	Gbeta5	IC	11313908	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DANRE|ZFIN=ZDB-GENE-000329-3|UniProtKB=Q7ZVF9	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00010	B cell activation	P00376	Ras	PANTR|Ensembl=ENSPTRG00000034469|UniProtKB=H2Q2V0	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CAEEL|WormBase=WBGene00004036|UniProtKB=G5EFI8	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00048	PI3 kinase pathway	G01546	Cyclin d	RAT|RGD=621083|UniProtKB=Q04827	G1/S-specific cyclin-D2	ISS			PTHR10177:SF66	G1/S-SPECIFIC CYCLIN-D2
P00057	Wnt signaling pathway	P01443	Phospholipase C	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IDA	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00029	Huntington disease	P00799	JNK-2	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	YEAST|SGD=S000000925|UniProtKB=P39962	Casein kinase I homolog 3	IDA	11437445	PubMed	PTHR11909:SF155	GILGAMESH, ISOFORM L
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	MACMU|Ensembl=ENSMMUG00000013637|UniProtKB=F7GL52	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00047	PDGF signaling pathway	P01162	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00021	FGF signaling pathway	P00623	FGF	MACMU|Ensembl=ENSMMUG00000012464|UniProtKB=F7FFR9	Fibroblast growth factor	ISS	11801566	PubMed	PTHR11486:SF25	FIBROBLAST GROWTH FACTOR 6
P00029	Huntington disease	P00776	c-Jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00009	Axon guidance mediated by netrin	P00365	MAX-1	CAEEL|WormBase=WBGene00003143|UniProtKB=G5ED24	MAX-1A	IDA	22058614	PubMed	PTHR22903:SF8	MAX-1A
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DANRE|ZFIN=ZDB-GENE-000329-1|UniProtKB=Q7ZVI7	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	GIAIC|EnsemblGenome=GL50803_40817|UniProtKB=A8BV70	Actin related protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	DANRE|ZFIN=ZDB-GENE-040516-3|UniProtKB=Q6NSN6	Serine/threonine-protein phosphatase	ISS	8392016	PubMed	PTHR11668:SF191	SERINE/THREONINE-PROTEIN PHOSPHATASE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PANTR|Ensembl=ENSPTRG00000006890|UniProtKB=H2Q943	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95816|UniProtKB=B1AS29	Glutamate receptor ionotropic, kainate 3	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04657	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00223	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00794	Hippi	CANLF|Ensembl=ENSCAFG00000009895|UniProtKB=F1P6B8	Uncharacterized protein	ISS	11889126	PubMed	PTHR16011:SF0	INTRAFLAGELLAR TRANSPORT PROTEIN 57 HOMOLOG
P04393	Ras Pathway	P04553	PAK	CHICK|Ensembl=ENSGALG00000000681|UniProtKB=E1C3P6	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P02721	ATP synthesis	P02794	F1 beta	XENTR|Xenbase=XB-GENE-943110|UniProtKB=F7CKS7	ATP synthase subunit beta	ISS	2896550	PubMed	PTHR15184:SF44	ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	ANOGA|EnsemblGenome=AGAP005912|UniProtKB=Q7Q6D3	AGAP005912-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2521|UniProtKB=P19020	D(3) dopamine receptor	IDA	2039532	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000014334|UniProtKB=F7CYY6	Uncharacterized protein	ISS	2137198	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	HUMAN|HGNC=1957|UniProtKB=P32297	Neuronal acetylcholine receptor subunit alpha-3	ISS	18005395	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P04398	p53 pathway feedback loops 2	P04657	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06739	MEK1/2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	RCA	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00054	Toll receptor signaling pathway	P01369	MKK1	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00005	Angiogenesis	P00220	c-Jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	12972619	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MOUSE|MGI=MGI=1276116|UniProtKB=B2RWS6	Histone acetyltransferase p300	ISS	10769018	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00586	Gq	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	TAS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00182	p38MAPK	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00113	Erb-B4 transmembrane fragment	RAT|RGD=620486|UniProtKB=Q62956	Receptor tyrosine-protein kinase erbB-4	IDA	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00920	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	DICDI|dictyBase=DDB_G0274605|UniProtKB=Q8SSQ0	Ras guanine nucleotide exchange factor R	ISS			PTHR23113:SF162	RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR R
P00057	Wnt signaling pathway	P01443	Phospholipase C	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	IDA	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IDA	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	CHICK|Ensembl=ENSGALG00000015336|UniProtKB=Q03481	Alpha8 subunit of nicotinic acetylcholine receptor	ISS	85270494	PubMed	PTHR18945:SF761	ALPHA8 SUBUNIT OF NICOTINIC ACETYLCHOLINE RECEPTOR
P00052	TGF-beta signaling pathway	P01275	P38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00036	Interleukin signaling pathway	P00983	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	3449797	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	PANTR|Ensembl=ENSPTRG00000001383|UniProtKB=H2Q053	Uncharacterized protein	ISS			PTHR23036:SF98	INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	MACMU|Ensembl=ENSMMUG00000014627|UniProtKB=F7GNE4	Catenin beta-1	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IDA	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P06664	Gonadotropin-releasing hormone receptor pathway	G06891	Junc	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	RCA	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00054	Toll receptor signaling pathway	P01352	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	BOVIN|Ensembl=ENSBTAG00000013632|UniProtKB=E1B965	Uncharacterized protein	ISS			PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	RCA			PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00005	Angiogenesis	P00238	Ras	DAPPU|EnsemblGenome=DAPPUDRAFT_301818|UniProtKB=E9I1I7	Putative uncharacterized protein	ISS			PTHR24070:SF385	GTPASE HRAS
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	MONDO|Ensembl=ENSMODG00000028212|UniProtKB=F7BYN4	Signal transducer and activator of transcription	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00045	Notch signaling pathway	P01103	Next	HUMAN|HGNC=6188|UniProtKB=P78504	Protein jagged-1	IGI	8955070	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	EMENI|EnsemblGenome=CADANIAG00008187|UniProtKB=Q00647	Myosin-1	IC			PTHR13140:SF663	HEAVY CHAIN, UNCONVENTIONAL MYOSIN
P05731	GABA-B receptor II signaling	P05754	Ggamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00012	Cadherin signaling pathway	P00470	F-actin	PLAF7|EnsemblGenome=PFL2215w|UniProtKB=Q8I4X0	Actin-1	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00018	EGF receptor signaling pathway	P00551	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01443	Phospholipase C	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	PANTR|Ensembl=ENSPTRG00000018684|UniProtKB=C7G3M7	Glutamate receptor, metabotropic 1	ISS	7476890	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g169611|UniProtKB=A7SEB1	Predicted protein	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00010	B cell activation	P00384	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IDA	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00628	JNK1-3	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IGI	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	TAS	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00539	14-3-3	CHICK|Gene_ORFName=RCJMB04_5e12|UniProtKB=Q5F3W6	14-3-3 protein gamma	ISS	22165492	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	14744463	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00036	Interleukin signaling pathway	P00977	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00047	PDGF signaling pathway	P01143	ERK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	HUMAN|HGNC=18123|UniProtKB=Q8NER5	Activin receptor type-1C	IDA			PTHR23255:SF58	ACTIVIN RECEPTOR TYPE-1C
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01192	p110	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	CANLF|Ensembl=ENSCAFG00000023650|UniProtKB=E2QWU0	Actin-related protein 2/3 complex subunit 4	ISS	5031595	gi	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00021	FGF signaling pathway	P00627	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CAEEL|WormBase=WBGene00000046|UniProtKB=P45963	Acetylcholine receptor subunit alpha-type acr-7	IC			PTHR18945:SF426	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-TYPE ACR-7
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00055	Transcription regulation by bZIP transcription factor	P01390	TFIIA complex	HUMAN|HGNC=30727|UniProtKB=Q9UNN4	TFIIA-alpha and beta-like factor	ISS			PTHR12694:SF9	PROTEIN STON1-GTF2A1L-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	TAS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00029	Huntington disease	P00775	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	10540223	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	CANLF|Ensembl=ENSCAFG00000018170|UniProtKB=E2RPM8	Tyrosine-protein kinase receptor	ISS	11182407	gi	PTHR24416:SF402	INSULIN RECEPTOR
P04396	Vitamin D metabolism and pathway	P04607	FDX	DROME|FlyBase=FBgn0011769|UniProtKB=P37193	Adrenodoxin-like protein, mitochondrial	ISS			PTHR23426:SF45	ADRENODOXIN-LIKE PROTEIN, MITOCHONDRIAL
P00029	Huntington disease	P00811	Arp2/3 complex	HUMAN|HGNC=704|UniProtKB=O15143	Actin-related protein 2/3 complex subunit 1B	TAS	12963527	gi	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00025	Hedgehog signaling pathway	P00699	Su(fu)	CHICK|Ensembl=ENSGALG00000008096|UniProtKB=Q8QG94	Suppressor of fused homolog	ISS			PTHR10928:SF2	SUPPRESSOR OF FUSED HOMOLOG
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00004	Alzheimer disease-presenilin pathway	P00118	E-cadherin	HUMAN|HGNC=1748|UniProtKB=P12830	Cadherin-1	IDA	8120095	PubMed	PTHR24027:SF319	CADHERIN-1
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	IC	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00052	TGF-beta signaling pathway	P01284	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00010	B cell activation	P00386	Calcineurin	MACMU|Ensembl=ENSMMUG00000015714|UniProtKB=F6SFE0	Serine/threonine-protein phosphatase	ISS	12091710	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00054	Toll receptor signaling pathway	P01377	MyD88	PANTR|Ensembl=ENSPTRG00000014754|UniProtKB=B3Y678	Myeloid differentiation primary response protein MyD88	ISS			PTHR15079:SF3	MYELOID DIFFERENTIATION PRIMARY RESPONSE PROTEIN MYD88
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00054	Toll receptor signaling pathway	P01352	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	HUMAN|HGNC=1952|UniProtKB=P20309	Muscarinic acetylcholine receptor M3	IDA	10069496	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	HUMAN|HGNC=4393|UniProtKB=P11488	Guanine nucleotide-binding protein G(t) subunit alpha-1	ISS	6264430	PubMed	PTHR10218:SF67	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00552	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IGI	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	RAT|RGD=619787|UniProtKB=A0A0G2K149	Protein Trpc5	IDA	11055438	PubMed	PTHR10117:SF24	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 5
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01438	PP2A	ANOGA|EnsemblGenome=AGAP010172|UniProtKB=Q7PD38	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MONDO|Ensembl=ENSMODG00000005623|UniProtKB=F7CFG8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	DANRE|ZFIN=ZDB-GENE-090312-169|UniProtKB=E7F8A2	Uncharacterized protein	ISS	22213672	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	RAT|RGD=3693|UniProtKB=Q01818	Chromaffin granule amine transporter	ISS	92370677	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00034	Integrin signalling pathway	P00949	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	95096035	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00046	Oxidative stress response	P01122	TRX	DROME|FlyBase=FBgn0011761|UniProtKB=P47938	Thioredoxin-1	TAS	12115731	PubMed	PTHR10438:SF359	THIOREDOXIN
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00236	PI3K	DROME|FlyBase=FBgn0020622|UniProtKB=Q7KTZ2	Pi3K21B, isoform B	ISS	7937853	PubMed	PTHR10155:SF0	PI3K21B, ISOFORM B
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00644	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BOVIN|Ensembl=ENSBTAG00000014614|UniProtKB=P62739	Actin, aortic smooth muscle	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	CHICK|Ensembl=ENSGALG00000019382|UniProtKB=E1BWK1	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00054	Toll receptor signaling pathway	P01381	Ubc13	DANRE|ZFIN=ZDB-GENE-040426-2873|UniProtKB=Q803J2	Ube2n protein	ISS			PTHR43902:SF2	UBIQUITIN-CONJUGATING ENZYME E2 N
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	EMENI|EnsemblGenome=CADANIAG00002670|UniProtKB=Q5BH99	G-protein beta subunit [Source:UniProtKB/TrEMBLAcc:O74214]	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P02728	Arginine biosynthesis	P02842	N-acetylornithine aminotransferase	METJA|EnsemblGenome=MJ_0721|UniProtKB=Q58131	Acetylornithine aminotransferase	ISS	10074354	PubMed	PTHR11986:SF79	ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00018	EGF receptor signaling pathway	P00552	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00642	MEK1-2	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00053	T cell activation	P01332	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	HUMAN|HGNC=6205|UniProtKB=P17275	Transcription factor jun-B	TAS	10664585	PubMed	PTHR11462:SF37	TRANSCRIPTION FACTOR JUN-B
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8699|UniProtKB=O60330	Protocadherin gamma-A12	IDA	8120095	PubMed	PTHR24028:SF227	PROTOCADHERIN GAMMA-A12
P05730	Endogenous cannabinoid signaling	P05743	CB1	HUMAN|HGNC=2159|UniProtKB=P21554	Cannabinoid receptor 1	TAS	114610	OMIM	PTHR22750:SF47	CANNABINOID RECEPTOR 1
P00016	Cytoskeletal regulation by Rho GTPase	P00520	Rho GAPs	MACMU|Ensembl=ENSMMUG00000007831|UniProtKB=F7CI83	Rho GTPase-activating protein 1	ISS	14724572	PubMed	PTHR23176:SF28	RHO GTPASE-ACTIVATING PROTEIN 1
P02770	Pyridoxal phosphate salvage pathway	P03122	Pyridoxamine kinase	RAT|RGD=621324|UniProtKB=O35331	Pyridoxal kinase	ISS	20344886	gi	PTHR10534:SF2	PYRIDOXAL KINASE
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_94959|UniProtKB=C3XYC4	Putative uncharacterized protein	IDA	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	14744463	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00018	EGF receptor signaling pathway	P00539	14-3-3	RAT|RGD=62000|UniProtKB=P62260	14-3-3 protein epsilon	ISS	98119747	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05915	Opioid proenkephalin pathway	P05994	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	RCA	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	RAT|RGD=620761|UniProtKB=Q9R172	Neurogenic locus notch homolog protein 3	IDA	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00046	Oxidative stress response	P01131	MKP5	CANLF|Ensembl=ENSCAFG00000030240|UniProtKB=J9P6D6	Dual specificity protein phosphatase	ISS			PTHR10159:SF111	DUAL SPECIFICITY PROTEIN PHOSPHATASE 4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	MOUSE|MGI=MGI=106684|UniProtKB=Q8R090	Chromaffin granule amine transporter	ISS	92370677	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MACMU|Ensembl=ENSMMUG00000017374|UniProtKB=F7H6T7	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00018	EGF receptor signaling pathway	P00539	14-3-3	MONDO|Ensembl=ENSMODG00000010174|UniProtKB=F6TA21	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00046	Oxidative stress response	P01135	p38	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	TAS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00005	Angiogenesis	P00207	Crk	ORNAN|Ensembl=ENSOANG00000007759|UniProtKB=F7CN41	Uncharacterized protein	ISS			PTHR19969:SF8	ADAPTER MOLECULE CRK
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	IDA	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00059	p53 pathway	P04609	PI3K	DROME|FlyBase=FBgn0015277|UniProtKB=Q9W1M7	Phosphatidylinositol 3-kinase	ISS			PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000008719|UniProtKB=F1MZX0	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00023	General transcription regulation	P00658	TBP-associated factors	ARATH|TAIR=AT3G02160|UniProtKB=Q9S7R9	At3g02160	ISS	604905	OMIM	PTHR12321:SF53	BROMODOMAIN TRANSCRIPTION FACTOR
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=69424|UniProtKB=Q99P84	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	7822322	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P04393	Ras Pathway	P04547	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	MOUSE|MGI=MGI=88547|UniProtKB=O54833	Casein kinase II subunit alpha'	IDA	10617630	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	RAT|RGD=71027|UniProtKB=P42264	Glutamate receptor ionotropic, kainate 3	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00054	Toll receptor signaling pathway	P01361	TBK1	PANTR|Ensembl=ENSPTRG00000005174|UniProtKB=H2Q6E2	TANK-binding kinase 1	ISS			PTHR22969:SF14	SERINE/THREONINE-PROTEIN KINASE TBK1
P00052	TGF-beta signaling pathway	P01275	P38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	TAS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00056	VEGF signaling pathway	P01425	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00060	Ubiquitin proteasome pathway	P01491	E2	EMENI|EnsemblGenome=CADANIAG00010348|UniProtKB=Q5B9M0	UBC1_COLGL Ubiquitin-conjugating enzyme E2-16 kDa (Ubiquitin-protein ligase) (Ubiquitin carrier protein) (Colletotrichum hard-surface-induced protein 1)	ISS			PTHR24068:SF74	FI16911P1-RELATED
P00018	EGF receptor signaling pathway	P00539	14-3-3	ORYSJ|EnsemblGenome=OS11G0546900|UniProtKB=Q2R2W2	14-3-3-like protein GF14-D	ISS	10918058	PubMed	PTHR18860:SF34	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01407	Erk	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	TAS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P02772	Pyruvate metabolism	P03140	Pyruvate Carboxylase	BOVIN|Ensembl=ENSBTAG00000019700|UniProtKB=Q29RK2	Pyruvate carboxylase, mitochondrial	ISS	12112657	PubMed	PTHR43778:SF2	PYRUVATE CARBOXYLASE, MITOCHONDRIAL
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	MACMU|Ensembl=ENSMMUG00000012422|UniProtKB=F7DJH4	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	TAS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	CANLF|Gene=PSEN1|UniProtKB=Q6RH31	Presenilin-1	ISS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00019	Endothelin signaling pathway	P00566	ERK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	NAS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00057	Wnt signaling pathway	P01428	Frizzled	ANOGA|Gene=AgaP_AGAP008871|UniProtKB=Q7PWS3	AGAP008871-PA (Fragment)	ISS	8717036	PubMed	PTHR11309:SF23	FRIZZLED-4
P00051	TCA cycle	P01274	Succinyl CoA Synthetase	TRIVA|Gene=TVAG_165340|UniProtKB=A2DUL5	Uncharacterized protein	IDA	7808480	PubMed	PTHR11117:SF2	SUCCINYL-COA LIGASE  ADP/GDP-FORMING  SUBUNIT ALPHA, MITOCHONDRIAL
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00587	Raf-1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00060	Ubiquitin proteasome pathway	P01490	E3	BOVIN|Ensembl=ENSBTAG00000016764|UniProtKB=A3KMV5	Ubiquitin-like modifier-activating enzyme 1	ISS			PTHR10953:SF155	UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 1
P04393	Ras Pathway	P04542	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04570	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00052	TGF-beta signaling pathway	P01275	P38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	TAS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00049	Parkinson disease	P01227	20S proteasome	TRYB2|Gene=Tb927.4.430|UniProtKB=D6XEX9	Proteasome subunit beta type	ISS	12859888	PubMed	PTHR11599:SF5	PROTEASOME SUBUNIT BETA TYPE-4
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	ANOGA|EnsemblGenome=AGAP006027|UniProtKB=Q7PNT0	AGAP006027-PA	IC	10331083	PubMed	PTHR18966:SF270	GLUTAMATE RECEPTOR 1-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	RAT|RGD=1306522|UniProtKB=Q4L0E8	Regulator of G-protein signaling 18	ISS	11563974	PubMed	PTHR10845:SF155	REGULATOR OF G-PROTEIN SIGNALING 18
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00029	Huntington disease	P00788	Calpain	BOVIN|Ensembl=ENSBTAG00000006479|UniProtKB=E1BIX3	Uncharacterized protein	ISS	11675509	PubMed	PTHR10183:SF22	CALPAIN-7
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	TAS	97102675	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00029	Huntington disease	P00810	GAPDH	ANOGA|EnsemblGenome=AGAP009623|UniProtKB=Q7Q1U8	Glyceraldehyde-3-phosphate dehydrogenase	IPI			PTHR10836:SF52	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED
P00005	Angiogenesis	P00206	Wnt	MOUSE|MGI=MGI=98961|UniProtKB=P24383	Protein Wnt-7a	ISS	11266476	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00020	FAS signaling pathway	P00601	c-Jun	XENTR|Xenbase=XB-GENE-482228|UniProtKB=F6RYL1	Uncharacterized protein	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00006	Apoptosis signaling pathway	P00269	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04657	P110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00052	TGF-beta signaling pathway	P01275	P38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	TAS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00034	Integrin signalling pathway	P00948	Rho	DANRE|ZFIN=ZDB-GENE-040426-2150|UniProtKB=Q6NUX8	Rho-related GTP-binding protein RhoA-A	ISS	12024019	PubMed	PTHR24072:SF260	RHO-RELATED GTP-BINDING PROTEIN RHOA-A-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00790	beta-Tubulin	MACMU|Ensembl=ENSMMUG00000012546|UniProtKB=F7E840	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00056	VEGF signaling pathway	P01411	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05731	GABA-B receptor II signaling	P05755	Gbeta	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00025	Hedgehog signaling pathway	P00692	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	7667318	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00029	Huntington disease	P00807	Actin	CHLRE|EnsemblGenome=CHLREDRAFT_24392|UniProtKB=A8JAV1	Actin	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00056	VEGF signaling pathway	P01408	Akt/PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01391	TFIIFalpha	HUMAN|HGNC=4652|UniProtKB=P35269	General transcription factor IIF subunit 1	ISS	12732728	PubMed	PTHR13011:SF0	GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1
P02775	Salvage pyrimidine ribonucleotides	P03152	Uridine phosphorylase	HUMAN|HGNC=23061|UniProtKB=O95045	Uridine phosphorylase 2	ISS			PTHR43691:SF8	URIDINE PHOSPHORYLASE 2
P00018	EGF receptor signaling pathway	P00542	EGFR	PANTR|Ensembl=ENSPTRG00000019196|UniProtKB=H2QUL1	Receptor protein-tyrosine kinase	ISS	21100872	PubMed	PTHR24416:SF91	EPIDERMAL GROWTH FACTOR RECEPTOR
P00048	PI3 kinase pathway	P01182	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00012	Cadherin signaling pathway	P00474	Wnt	MACMU|Ensembl=ENSMMUG00000006921|UniProtKB=F7EV26	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00006	Apoptosis signaling pathway	P00321	HSP70	DROME|FlyBase=FBgn0013275|UniProtKB=P82910	Major heat shock 70 kDa protein Aa	ISS	12150907	PubMed	PTHR19375:SF256	HSP70 PROTEIN-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00004	Alzheimer disease-presenilin pathway	P00128	Erb-B4	CHICK|Ensembl=ENSGALG00000003126|UniProtKB=F1P258	Receptor protein-tyrosine kinase	ISS	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00004	Alzheimer disease-presenilin pathway	P00168	E-cadherin intracellular fragment	PANTR|Ensembl=ENSPTRG00000008270|UniProtKB=H2QBE5	Uncharacterized protein	ISS	11953314	PubMed	PTHR24027:SF319	CADHERIN-1
P00034	Integrin signalling pathway	P00910	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	9763606	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00018	EGF receptor signaling pathway	P00542	EGFR	BOVIN|Ensembl=ENSBTAG00000010444|UniProtKB=A6QR62	ERBB3 protein	ISS	20477399	gi	PTHR24416:SF88	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00021	FGF signaling pathway	P00632	Akt	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	IGI	12655147	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00990	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DROME|FlyBase=FBgn0000046|UniProtKB=P10981	Actin-87E	IDA	10974003	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	CAEEL|WormBase=WBGene00003911|UniProtKB=Q17850	Serine/threonine-protein kinase pak-1	ISS			PTHR24361:SF456	P21-ACTIVATED KINASE, ISOFORM F
P00020	FAS signaling pathway	P00594	Caspase8	HUMAN|HGNC=1509|UniProtKB=Q14790	Caspase-8	ISS	11788820	PubMed	PTHR10454:SF162	CASPASE-8
P00029	Huntington disease	P00780	Microtubule	NEMVE|Gene=v1g118944|UniProtKB=A7SHY4	Predicted protein (Fragment)	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00012	Cadherin signaling pathway	P00474	Wnt	PANTR|Ensembl=ENSPTRG00000015034|UniProtKB=H2QMT4	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00006	Apoptosis signaling pathway	P00269	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	21150461	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04385	Histamine H1 receptor mediated signaling pathway	P04485	H1	RAT|RGD=2830|UniProtKB=P31390	Histamine H1 receptor	ISS	11841575	PubMed	PTHR43914:SF2	HISTAMINE H1 RECEPTOR
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MACMU|Ensembl=ENSMMUG00000012054|UniProtKB=F6TII3	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00018	EGF receptor signaling pathway	P00539	14-3-3	HUMAN|HGNC=12852|UniProtKB=P61981	14-3-3 protein gamma	ISS	99360936	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	HUMAN|HGNC=2090|UniProtKB=P09496	Clathrin light chain A	IDA	9388255	PubMed	PTHR10639:SF1	CLATHRIN LIGHT CHAIN A
P00019	Endothelin signaling pathway	P00590	IP3 R	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	IGI	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00011	Blood coagulation	P00416	Prothrombin	PANTR|Ensembl=ENSPTRG00000003552|UniProtKB=H2Q3I2	Prothrombin	ISS	176930	OMIM	PTHR24254:SF10	PROTHROMBIN
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00577	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IGI	1171954	gi	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00048	PI3 kinase pathway	P01177	P110ACT	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	IC	15531926	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04397	p53 pathway by glucose deprivation	G04706	TSC2	CANLF|Ensembl=ENSCAFG00000019438|UniProtKB=F1Q054	Uncharacterized protein	ISS	12150915	PubMed	PTHR10063:SF0	TUBERIN
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00034	Integrin signalling pathway	P00936	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IPI	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TAKRU|Ensembl=ENSTRUG00000014318|UniProtKB=H2UI49	Uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00020	FAS signaling pathway	P00616	Nuclear Lamin	MACMU|Ensembl=ENSMMUG00000000823|UniProtKB=F6Q273	Lamin-B1 isoform 1	ISS	11165516	PubMed	PTHR23239:SF157	LAMIN-B1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	IC	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00057	Wnt signaling pathway	P01448	CBP	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00047	PDGF signaling pathway	P01171	PLCgamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00023	General transcription regulation	P00658	TBP-associated factors	PANTR|Ensembl=ENSPTRG00000020535|UniProtKB=H2R9Q1	TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa	ISS			PTHR15137:SF9	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IC	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00054	Toll receptor signaling pathway	P01352	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00922	Collagen	MACMU|Ensembl=ENSMMUG00000013235|UniProtKB=F6ZKE4	Uncharacterized protein	ISS	10778855	PubMed	PTHR24023:SF435	COLLAGEN ALPHA-3 IV  CHAIN
P00038	JAK/STAT signaling pathway	P01027	STAT	MONDO|Ensembl=ENSMODG00000014816|UniProtKB=F7CHH2	Signal transducer and activator of transcription	ISS	96102059	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	MACMU|Ensembl=ENSMMUG00000014817|UniProtKB=F6VXD8	Uncharacterized protein	ISS	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	TAKRU|Ensembl=ENSTRUG00000015959|UniProtKB=H2UV27	Uncharacterized protein	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02772	Pyruvate metabolism	P03132	Pyruvate Kinase	HUMAN|HGNC=9021|UniProtKB=P14618	Pyruvate kinase PKM	TAS	8193145	PubMed	PTHR11817:SF15	PYRUVATE KINASE PKM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00006	Apoptosis signaling pathway	P00321	HSP70	YARLI|EnsemblGenome=YALI0_E13706g|UniProtKB=Q99170	78 kDa glucose-regulated protein homolog	ISS	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00021	FGF signaling pathway	P00629	PP2A	MACMU|Ensembl=ENSMMUG00000013047|UniProtKB=F7H808	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00029	Huntington disease	P00779	TBP	METAC|EnsemblGenome=MA_0278|UniProtKB=Q8TTZ7	TATA-box-binding protein 3	IPI	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=5301|UniProtKB=P50406	5-hydroxytryptamine receptor 6	IDA			PTHR24247:SF114	5-HYDROXYTRYPTAMINE RECEPTOR 6
P00021	FGF signaling pathway	P00631	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MOUSE|MGI=MGI=1309999|UniProtKB=Q922R0	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	RAT|RGD=2522|UniProtKB=P30729	D(4) dopamine receptor	ISS	11248120	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01411	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	CHICK|Ensembl=ENSGALG00000016406|UniProtKB=F1NLJ3	Uncharacterized protein	ISS	2779569	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04393	Ras Pathway	P04546	GSK3	BOVIN|Ensembl=ENSBTAG00000020756|UniProtKB=A6QLB8	GSK3A protein	ISS	11995474	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IDA	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00005	Angiogenesis	P00240	FRS-2	CHICK|Ensembl=ENSGALG00000009966|UniProtKB=E1C021	Uncharacterized protein	ISS	10464310	PubMed	PTHR21258:SF40	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00581	Guanylate cyclase	MOUSE|MGI=MGI=1860604|UniProtKB=O54865	Guanylate cyclase soluble subunit beta-1	RCA			PTHR11920:SF318	GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-1
P02788	Xanthine and guanine salvage pathway	P03245	Guanine phosphoribosyl transferase	PSEAE|EnsemblGenome=PA4645|UniProtKB=Q9HVE7	Probable purine/pyrimidine phosphoribosyl transferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01292	RSmads	PANTR|Ensembl=ENSPTRG00000016485|UniProtKB=H2QQ88	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P00047	PDGF signaling pathway	P01174	Rho	DROME|FlyBase=FBgn0030893|UniProtKB=X2JCF3	Rho GTPase activating protein at 16F, isoform E	ISS	8288572	PubMed	PTHR23181:SF10	RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00017	DNA replication	P00527	Histones	CANAL|CGD=CAL0000190019|UniProtKB=Q5ADQ0	Histone H3.3	ISS	12413958	PubMed	PTHR11426:SF169	HISTONE H3
P00024	Glycolysis	P00680	Phosphoglyceromutase	PANTR|Ensembl=ENSPTRG00000019720|UniProtKB=H2QVE8	Uncharacterized protein	ISS	2542247	PubMed	PTHR11931:SF11	BISPHOSPHOGLYCERATE MUTASE
P00018	EGF receptor signaling pathway	P00564	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00057	Wnt signaling pathway	P01435	SWI/SNF	CANLF|Ensembl=ENSCAFG00000017584|UniProtKB=E2RJ89	Uncharacterized protein	ISS	11532957	PubMed	PTHR10799:SF76	TRANSCRIPTION ACTIVATOR BRG1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	PHYIT|EnsemblGenome=PITG_06376|UniProtKB=D0N4Q3	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta, putative	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00049	Parkinson disease	P01236	Casein kinase II	CAEEL|WormBase=WBGene00002191|UniProtKB=P18334	Casein kinase II subunit alpha	IDA	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014262|UniProtKB=F7BYS8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00047	PDGF signaling pathway	P01155	Jak	MONDO|Ensembl=ENSMODG00000015373|UniProtKB=F6WH53	Tyrosine-protein kinase	ISS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00021	FGF signaling pathway	P00640	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	RAT|RGD=2027|UniProtKB=P63269	Actin, gamma-enteric smooth muscle	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00047	PDGF signaling pathway	P01160	IP3 receptor	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00586	Gq	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00046	Oxidative stress response	P01132	c-jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	ARATH|TAIR=AT5G07880|UniProtKB=Q9SD96	SNAP25 homologous protein SNAP29	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00005	Angiogenesis	P00244	MAPKAPK2/3	HUMAN|HGNC=6888|UniProtKB=Q16644	MAP kinase-activated protein kinase 3	IDA	11335727	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00057	Wnt signaling pathway	P01440	Cadherin	DROME|FlyBase=FBgn0036715|UniProtKB=Q9VVG0	Cadherin 74A, isoform A	ISS	8120095	PubMed	PTHR43956:SF5	CADHERIN 74A, ISOFORM A
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00012	Cadherin signaling pathway	P00470	F-actin	CANLF|Ensembl=ENSCAFG00000015708|UniProtKB=F2Z4N0	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00012	Cadherin signaling pathway	P00475	Frizzled	RAT|RGD=2321905|UniProtKB=D4ACM8	Protein Fzd7	ISS	8717036	PubMed	PTHR11309:SF31	FRIZZLED-7
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00047	PDGF signaling pathway	P01161	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04558	p38	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	IDA	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00016	Cytoskeletal regulation by Rho GTPase	P00507	Rho	BOVIN|Ensembl=ENSBTAG00000014299|UniProtKB=Q1RMJ6	Rho-related GTP-binding protein RhoC	ISS	12090470	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=69424|UniProtKB=Q99P84	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	15611108	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P05918	p38 MAPK pathway	P05921	MKP5	CANLF|Ensembl=ENSCAFG00000013641|UniProtKB=E2R7G4	Uncharacterized protein	ISS	11856337	PubMed	PTHR10159:SF299	DUAL SPECIFICITY PROTEIN PHOSPHATASE 10
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P02721	ATP synthesis	P02796	F1 gamma	BOVIN|Ensembl=ENSBTAG00000013930|UniProtKB=P05631	ATP synthase subunit gamma, mitochondrial	ISS	9525963	PubMed	PTHR11693:SF22	ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL
P00056	VEGF signaling pathway	P01413	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05918	p38 MAPK pathway	P06017	MNK2	MOUSE|MGI=MGI=894279|UniProtKB=Q8CDB0	MAP kinase-interacting serine/threonine-protein kinase 2	ISS	11463832	PubMed	PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	TAS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00035	Interferon-gamma signaling pathway	P00956	SOCS	MACMU|Ensembl=ENSMMUG00000000304|UniProtKB=F6YVE7	Suppressor of cytokine signaling 4	ISS	15032587	PubMed	PTHR44282:SF2	SUPPRESSOR OF CYTOKINE SIGNALING 4
P00059	p53 pathway	P04624	Cdc25C	MACMU|Ensembl=ENSMMUG00000009025|UniProtKB=F7CTB3	Uncharacterized protein	ISS	9520381	PubMed	PTHR10828:SF64	M-PHASE INDUCER PHOSPHATASE 3
P00029	Huntington disease	P00774	Dynein complex	STRPU|EnsemblGenome=SPU_004009|UniProtKB=W4XKT1	Uncharacterized protein	ISS	9454836	PubMed	PTHR11886:SF62	DYNEIN, LIGHT CHAIN, LC8-TYPE 2
P00006	Apoptosis signaling pathway	P00276	TRAIL-R	HUMAN|HGNC=11905|UniProtKB=O14763	Tumor necrosis factor receptor superfamily member 10B	IDA	11498783	PubMed	PTHR23097:SF88	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10B
P00005	Angiogenesis	P00240	FRS-2	PANTR|Ensembl=ENSPTRG00000005207|UniProtKB=H2Q6G0	Fibroblast growth factor receptor substrate 2	ISS	10464310	PubMed	PTHR21258:SF40	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01435	SWI/SNF	HUMAN|HGNC=11110|UniProtKB=O14497	AT-rich interactive domain-containing protein 1A	IDA	11532957	PubMed	PTHR12656:SF12	AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 1A
P00049	Parkinson disease	P01227	20S proteasome	XENTR|Xenbase=XB-GENE-1008325|UniProtKB=F7DUU5	Proteasome subunit beta type (Fragment)	ISS	12859888	PubMed	PTHR11599:SF62	PROTEASOME SUBUNIT BETA TYPE-3
P00006	Apoptosis signaling pathway	P00310	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IDA	7565716	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MACMU|Ensembl=ENSMMUG00000010392|UniProtKB=F7ASR8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00264	c-IAP1,2	MACMU|Ensembl=ENSMMUG00000003398|UniProtKB=F7FEI6	Uncharacterized protein	ISS	8552191	PubMed	PTHR10044:SF99	BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 3
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P02783	Tryptophan biosynthesis	P03209	Anthranilate phosphoribosyl transferase	ARATH|TAIR=AT1G24909|UniProtKB=Q9FE37	Anthranilate synthase beta subunit	ISS			PTHR43418:SF6	ANTHRANILATE SYNTHASE BETA SUBUNIT-RELATED
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	HUMAN|HGNC=143|UniProtKB=P68032	Actin, alpha cardiac muscle 1	IEP	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00898	FKHR	DANRE|ZFIN=ZDB-GENE-990708-6|UniProtKB=Q5TYS1	Uncharacterized protein	ISS			PTHR11829:SF309	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04542	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00036	Interleukin signaling pathway	P00996	STAT	BOVIN|Ensembl=ENSBTAG00000006335|UniProtKB=F1MGJ4	Signal transducer and activator of transcription	ISS	94367369	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P04397	p53 pathway by glucose deprivation	P04641	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IDA	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=4595|UniProtKB=Q14832	Metabotropic glutamate receptor 3	IDA	12351712	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	8920915	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04393	Ras Pathway	P04559	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	15470041	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00059	p53 pathway	P04616	PDK1/2	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	TAS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00030	Hypoxia response via HIF activation	P00817	TOR	MOUSE|MGI=MGI=1928394|UniProtKB=Q9JLN9	Serine/threonine-protein kinase mTOR	ISS	14526383	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00048	PI3 kinase pathway	P01185	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02749	Leucine biosynthesis	P03000	Branched chain amino acid aminotransferase	ARATH|TAIR=AT1G50090|UniProtKB=Q9LPM8	Putative branched-chain-amino-acid aminotransferase 7	ISS			PTHR42825:SF4	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 6-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00892	Grb2	CAEEL|WormBase=WBGene00004774|UniProtKB=P29355	Sex muscle abnormal protein 5	ISS	51702266	gi	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00053	T cell activation	P01312	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00024	Glycolysis	P00671	Phosphoglycerate kinase	PLAF7|EnsemblGenome=PFI1105w|UniProtKB=P27362	Phosphoglycerate kinase	ISS	91276232	PubMed	PTHR11406:SF0	PHOSPHOGLYCERATE KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	IC	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P04392	P53 pathway feedback loops 1	P04539	p53	RAT|RGD=1307083|UniProtKB=D4AA88	Protein Tp73	ISS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000008751|UniProtKB=H2QC89	Uncharacterized protein	ISS	129387	gi	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	HUMAN|HGNC=9509|UniProtKB=P49810	Presenilin-2	IDA	12846562	PubMed	PTHR10202:SF13	PRESENILIN-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CAEBR|Gene=CBG23091|UniProtKB=A8Y4Q9	Protein CBR-ACT-2	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	STRCO|Gene=CAB77419|UniProtKB=Q9L0L5	Aspartate aminotransferase	ISS			PTHR11751:SF306	SUBFAMILY NOT NAMED
P04371	5-Hydroxytryptamine biosynthesis	P04400	Aromatic L-amino acid decarboxylase	HUMAN|HGNC=2719|UniProtKB=P20711	Aromatic-L-amino-acid decarboxylase	ISS	7567987	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00054	Toll receptor signaling pathway	P01354	NFkappaB	MACMU|Ensembl=ENSMMUG00000002990|UniProtKB=F7GVV0	Uncharacterized protein	ISS	12574369	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00047	PDGF signaling pathway	P01169	Vav	PANTR|Ensembl=ENSPTRG00000001024|UniProtKB=H2PZI8	Uncharacterized protein	ISS	14623913	PubMed	PTHR22826:SF97	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	MOUSE|MGI=MGI=96281|UniProtKB=P34968	5-hydroxytryptamine receptor 2C	ISS	11859080	PubMed	PTHR24247:SF32	5-HYDROXYTRYPTAMINE RECEPTOR 2C
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00642	MEK1-2	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00021	FGF signaling pathway	P00638	PLCgamma	CAEBR|Gene=CBG18715|UniProtKB=A8XTZ1	Phosphoinositide phospholipase C	ISS			PTHR10336:SF91	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IGI	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	BOVIN|Ensembl=ENSBTAG00000008059|UniProtKB=P41984	Muscarinic acetylcholine receptor M3	IDA	11166329	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00049	Parkinson disease	P01242	Casein kinase I	SCHPO|PomBase=SPBC3H7.15|UniProtKB=P40235	Casein kinase I homolog hhp1	IDA	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00737	Rap1GAP	BOVIN|Ensembl=ENSBTAG00000006948|UniProtKB=E1BF85	Uncharacterized protein	ISS	10419452	PubMed	PTHR15711:SF31	GTPASE-ACTIVATING RAP/RAN-GAP DOMAIN-LIKE PROTEIN 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000019277|UniProtKB=H2QUQ1	Uncharacterized protein	ISS	1321498	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	CHICK|Gene_ORFName=RCJMB04_24e7|UniProtKB=P62149	Calmodulin	ISS	7514101	PubMed	PTHR23050:SF311	CALMODULIN
P00018	EGF receptor signaling pathway	P00544	c-Cbl	CAEEL|WormBase=WBGene00004829|UniProtKB=Q19019	Sli-1 protein	ISS			PTHR23007:SF11	CBL LONG ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00021	FGF signaling pathway	P00648	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00045	Notch signaling pathway	P01099	Notch	RAT|RGD=3187|UniProtKB=Q07008	Neurogenic locus notch homolog protein 1	IEP	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00005	Angiogenesis	P00221	JNK1	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01150	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00005	Angiogenesis	P00192	PAR	MOUSE|MGI=MGI=1337040|UniProtKB=O54915	Nuclear receptor subfamily 1 group I member 2	ISS			PTHR24082:SF39	NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IDA	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000002016|UniProtKB=F1P3G1	Protein kinase C delta type	IC	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	RAT|RGD=2522|UniProtKB=P30729	D(4) dopamine receptor	IDA	11248120	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P02741	Flavin biosynthesis	P02933	Pyrimidine deaminase	AQUAE|EnsemblGenome=aq_138|UniProtKB=O66534	Riboflavin biosynthesis protein RibD	ISS			PTHR44288:SF1	RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBD
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04398	p53 pathway feedback loops 2	P04665	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00047	PDGF signaling pathway	P01155	Jak	MOUSE|MGI=MGI=96629|UniProtKB=Q62120	Tyrosine-protein kinase JAK2	ISS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00010	B cell activation	P00385	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00047	PDGF signaling pathway	P01161	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MACMU|Ensembl=ENSMMUG00000017683|UniProtKB=F6UA63	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00012	Cadherin signaling pathway	P00474	Wnt	BOVIN|Ensembl=ENSBTAG00000010820|UniProtKB=F1N4C0	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00057	Wnt signaling pathway	P01472	Histone deacetylase	CANAL|CGD=CAL0005111|UniProtKB=Q5A209	Histone deacetylase	IDA	10485845	PubMed	PTHR10625:SF141	HISTONE DEACETYLASE RPD3
P00006	Apoptosis signaling pathway	P00318	PKCs	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00010	B cell activation	P00397	IKK	BOVIN|Ensembl=ENSBTAG00000007591|UniProtKB=Q95KV1	Inhibitor of nuclear factor kappa-B kinase subunit alpha	IGI	14499113	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00021	FGF signaling pathway	P00626	Spry	MACMU|Ensembl=ENSMMUG00000001662|UniProtKB=F7G6M6	Uncharacterized protein	ISS			PTHR12365:SF9	PROTEIN SPROUTY HOMOLOG 3
P00005	Angiogenesis	P00203	Erk	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	IDA	12846562	PubMed	PTHR10202:SF13	PRESENILIN-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00629	PP2A	ARATH|TAIR=AT1G54450|UniProtKB=Q9SLI8	Probable serine/threonine protein phosphatase 2A regulatory subunit B''delta	ISS			PTHR14095:SF0	SERINE/THREONINE PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B''ALPHA-RELATED
P02788	Xanthine and guanine salvage pathway	P03245	Guanine phosphoribosyl transferase	MOUSE|MGI=MGI=96217|UniProtKB=P00493	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF6	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE
P00048	PI3 kinase pathway	P01192	p110	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04397	p53 pathway by glucose deprivation	P04640	p53	HUMAN|HGNC=11998|UniProtKB=P04637	Cellular tumor antigen p53	TAS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MACMU|Ensembl=ENSMMUG00000005819|UniProtKB=F6VKI4	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P05913	Enkephalin release	P05971	CREB	XENTR|Xenbase=XB-GENE-945015|UniProtKB=F6QA46	Uncharacterized protein	ISS	11390664	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00029	Huntington disease	P00807	Actin	HUMAN|HGNC=145|UniProtKB=P63267	Actin, gamma-enteric smooth muscle	IDA	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	RCA	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	MACMU|Ensembl=ENSMMUG00000012005|UniProtKB=F7H091	Metabotropic glutamate receptor 2 isoform a	ISS	12351712	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00030	Hypoxia response via HIF activation	P00821	Prolyl Hydroxylase	HUMAN|HGNC=1232|UniProtKB=Q9GZT9	Egl nine homolog 1	IDA	12912907	PubMed	PTHR12907:SF4	EGL NINE HOMOLOG 1
P00059	p53 pathway	G04694	p110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00009	Axon guidance mediated by netrin	P00366	Rac	CHICK|Ensembl=ENSGALG00000002859|UniProtKB=F6UBD2	Uncharacterized protein	ISS	9252344	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	CHICK|Ensembl=ENSGALG00000008058|UniProtKB=F1N8W8	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00049	Parkinson disease	P01208	Hsp70	ARATH|TAIR=AT5G02500|UniProtKB=P22953	Probable mediator of RNA polymerase II transcription subunit 37e	IDA	12150907	PubMed	PTHR19375:SF325	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 37E-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	RAT|RGD=621404|UniProtKB=Q62761	Casein kinase I isoform gamma-1	ISS	11437445	PubMed	PTHR11909:SF156	CASEIN KINASE I ISOFORM GAMMA-1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00053	T cell activation	P01336	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00036	Interleukin signaling pathway	P00983	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	12068308	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P04398	p53 pathway feedback loops 2	P04665	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	HUMAN|HGNC=4580|UniProtKB=Q13002	Glutamate receptor ionotropic, kainate 2	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00474	Wnt	CHICK|Ensembl=ENSGALG00000000839|UniProtKB=P49339	Protein Wnt-11	IDA	11266476	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04433	Beta1	PANTR|Ensembl=ENSPTRG00000002956|UniProtKB=H2Q2L5	Uncharacterized protein	ISS	12063255	PubMed	PTHR24248:SF54	BETA-1 ADRENERGIC RECEPTOR
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	HUMAN|HGNC=9994|UniProtKB=O14924	Regulator of G-protein signaling 12	IDA	8756726	PubMed	PTHR10845:SF149	REGULATOR OF G-PROTEIN SIGNALING 12
P00047	PDGF signaling pathway	P01151	PKB	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00060	Ubiquitin proteasome pathway	P01491	E2	TAKRU|Ensembl=ENSTRUG00000009326|UniProtKB=H2TFL0	Uncharacterized protein	ISS			PTHR24068:SF120	UBIQUITIN-CONJUGATING ENZYME E2D 2  UBC4/5 HOMOLOG, YEAST
P00034	Integrin signalling pathway	P00941	Integrin alpha	HUMAN|HGNC=6138|UniProtKB=P08514	Integrin alpha-IIb	IPI	3487386	PubMed	PTHR23220:SF73	INTEGRIN ALPHA-IIB
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00034	Integrin signalling pathway	P00912	Arp2/3	RAT|RGD=1305848|UniProtKB=P85970	Actin-related protein 2/3 complex subunit 2	ISS	10940259	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00047	PDGF signaling pathway	P01143	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	10755300	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00005	Angiogenesis	P00233	CSL	RAT|RGD=1310557|UniProtKB=F1LNW1	Protein Rbpj	ISS	15187023	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IDA	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00049	Parkinson disease	P01211	ERK	ORYSJ|EnsemblGenome=OS02G0148100|UniProtKB=Q6Z437	Mitogen-activated protein kinase 3	IDA	7341300	gi	PTHR24055:SF216	SUBFAMILY NOT NAMED
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	88234494	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TRYB2|Gene=Tb09.211.0620|UniProtKB=Q38E94	Actin A	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00049	Parkinson disease	P01219	SAPK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00038	JAK/STAT signaling pathway	P01027	STAT	CANLF|Ensembl=ENSCAFG00000015213|UniProtKB=E2RB82	Signal transducer and activator of transcription	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	MACMU|Ensembl=ENSMMUG00000001079|UniProtKB=F6QMI5	Adenylate kinase 4, mitochondrial	ISS			PTHR23359:SF58	ADENYLATE KINASE 4, MITOCHONDRIAL
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ANOGA|EnsemblGenome=AGAP000651|UniProtKB=P84185	Actin-5C	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	PANTR|Ensembl=ENSPTRG00000023608|UniProtKB=H2QZZ2	Uncharacterized protein	ISS	11319238	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	PANTR|Ensembl=ENSPTRG00000018511|UniProtKB=H2QTK7	Tyrosine-protein kinase	ISS	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00053	T cell activation	P01298	NFkappaB	MACMU|Ensembl=ENSMMUG00000002990|UniProtKB=F7GVV0	Uncharacterized protein	ISS	9133421	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00047	PDGF signaling pathway	P01164	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	12855688	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	MOUSE|MGI=MGI=97511|UniProtKB=P63239	Neuroendocrine convertase 1	IDA			PTHR42884:SF14	NEUROENDOCRINE CONVERTASE 1
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	DANRE|ZFIN=ZDB-GENE-051202-2|UniProtKB=Q6ZM67	Uncharacterized protein	ISS	11554554	PubMed	PTHR44391:SF3	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IDA	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00019	Endothelin signaling pathway	P00578	eNOS	PANTR|Ensembl=ENSPTRG00000019868|UniProtKB=H2QVM2	Nitric oxide synthase	ISS	10435050	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DICDI|dictyBase=DDB_G0279413|UniProtKB=P05987	cAMP-dependent protein kinase regulatory subunit	IC	91072385	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05938	RhoA	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	ISS	15668138	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	IDA	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00034	Integrin signalling pathway	P00920	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	8170357	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000009085|UniProtKB=H2RDQ2	Uncharacterized protein	ISS	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00048	PI3 kinase pathway	P01188	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00005	Angiogenesis	P00243	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00638	PLCgamma	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	BOVIN|Ensembl=ENSBTAG00000012687|UniProtKB=F1MV64	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF402	INSULIN RECEPTOR
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00034	Integrin signalling pathway	P00948	Rho	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g243859|UniProtKB=A7S9Y5	Predicted protein	ISS	11973360	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IDA	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	MOUSE|MGI=MGI=104781|UniProtKB=P48542	G protein-activated inward rectifier potassium channel 2	IDA	2433589	PubMed	PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P00056	VEGF signaling pathway	P01407	Erk	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00057	Wnt signaling pathway	P01443	Phospholipase C	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	21071228	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00050	Plasminogen activating cascade	P01253	Fibrin	HUMAN|HGNC=3662|UniProtKB=P02675	Fibrinogen beta chain	IDA	11761631	gi	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00047	PDGF signaling pathway	P01155	Jak	MACMU|Ensembl=ENSMMUG00000014558|UniProtKB=F7GT47	Tyrosine-protein kinase	ISS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00006	Apoptosis signaling pathway	P00298	Caspase 9	MACMU|Ensembl=ENSMMUG00000018163|UniProtKB=F7FNC1	Caspase	ISS	8663294	PubMed	PTHR10454:SF157	CASPASE-9
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	88241036	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05913	Enkephalin release	P05977	G-Protein (s)	CANLF|Ensembl=ENSCAFG00000015662|UniProtKB=E2RHY4	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	IC	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-486685|UniProtKB=F6VT32	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	CANLF|Ensembl=ENSCAFG00000000332|UniProtKB=F1P8E3	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00049	Parkinson disease	P01238	14-3-3	HUMAN|HGNC=12851|UniProtKB=P62258	14-3-3 protein epsilon	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00048	PI3 kinase pathway	P01177	P110ACT	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04398	p53 pathway feedback loops 2	P04651	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P05730	Endogenous cannabinoid signaling	P05746	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00049	Parkinson disease	P01236	Casein kinase II	SCHPO|PomBase=SPAC1851.03|UniProtKB=P40232	Casein kinase II subunit beta	IDA	10617630	PubMed	PTHR11740:SF13	CASEIN KINASE II SUBUNIT BETA'
P00036	Interleukin signaling pathway	P00990	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00011	Blood coagulation	P00437	Kallikrein	MOUSE|MGI=MGI=102849|UniProtKB=P26262	Plasma kallikrein	ISS	6981134	gi	PTHR44459:SF2	PLASMA KALLIKREIN
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01188	Gbetagamma	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	IC	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00056	VEGF signaling pathway	P01415	MAPKAPK2/3	CANLF|Ensembl=ENSCAFG00000011432|UniProtKB=F1PZ82	Uncharacterized protein	ISS			PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00056	VEGF signaling pathway	P01414	PLC-gamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=98954|UniProtKB=P21552	Protein Wnt-2	IDA	8717036	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P05731	GABA-B receptor II signaling	P05754	Ggamma	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04393	Ras Pathway	P04556	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	3449797	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00006	Apoptosis signaling pathway	P00310	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04392	P53 pathway feedback loops 1	G04685	p73DeltaN	MOUSE|MGI=MGI=1330810|UniProtKB=O88898	Tumor protein 63	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P02736	Coenzyme A biosynthesis	P02882	Pantothenate cysteine ligase	MOUSE|MGI=MGI=1915237|UniProtKB=Q8VDG5	Phosphopantothenate--cysteine ligase	ISS			PTHR12290:SF2	PHOSPHOPANTOTHENATE--CYSTEINE LIGASE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	RAT|RGD=1309329|UniProtKB=F1MAD0	Protein Lrp5	ISS	11029006	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00034	Integrin signalling pathway	P00924	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00057	Wnt signaling pathway	P01454	betaTrCP	HUMAN|HGNC=13607|UniProtKB=Q9UKB1	F-box/WD repeat-containing protein 11	IDA	12628165	PubMed	PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P00047	PDGF signaling pathway	P01149	MNK1/2	RAT|RGD=1305728|UniProtKB=Q5U2N4	MAP kinase-interacting serine/threonine-protein kinase 2	ISS	11463832	PubMed	PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	IDA	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000008826|UniProtKB=F6XUU0	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00589	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=98957|UniProtKB=P22724	Protein Wnt-4	TAS	11266476	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00053	T cell activation	P01300	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04557	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	YARLI|EnsemblGenome=YALI0_D16863g|UniProtKB=Q6C8U8	YALI0D16863p	IDA	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MOUSE|MGI=MGI=1933206|UniProtKB=A2AIR5	Protein Grin3a	ISS	11554554	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P02788	Xanthine and guanine salvage pathway	P03250	Guanosine phosphorylase	THEMA|EnsemblGenome=TM_1737|UniProtKB=Q9X259	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_125875|UniProtKB=C3Y5C1	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF195	BETA-CENTRACTIN
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	LEIMA|EnsemblGenome=LmjF.35.3960|UniProtKB=E9AFM1	Protein kinase A catalytic subunit isoform 2	ISS	10218114	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01188	Gbetagamma	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05752	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05913	Enkephalin release	P05978	AC	RAT|RGD=619965|UniProtKB=P26769	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00547	PP2A	DANRE|ZFIN=ZDB-GENE-040426-877|UniProtKB=F1Q6Z7	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MACMU|Ensembl=ENSMMUG00000020084|UniProtKB=F7GP56	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF427	MYOSIN-3
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00019	Endothelin signaling pathway	P00570	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	CANLF|Ensembl=ENSCAFG00000012353|UniProtKB=E2RSE6	Uncharacterized protein	ISS	95328031	PubMed	PTHR42884:SF1	FURIN
P05731	GABA-B receptor II signaling	P05755	Gbeta	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	BACSU|EnsemblGenome=BSU29680|UniProtKB=P39062	Acetyl-coenzyme A synthetase	ISS			PTHR24095:SF14	ACETYL-COENZYME A SYNTHETASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00047	PDGF signaling pathway	P01162	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00011	Blood coagulation	P00406	Fibrinogen	RAT|RGD=2603|UniProtKB=P06399	Fibrinogen alpha chain	ISS	87134033	PubMed	PTHR19143:SF232	FIBRINOGEN ALPHA CHAIN
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00985	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04398	p53 pathway feedback loops 2	P04657	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P06959	CCKR signaling map	P07188	RHOA-GTP	HUMAN|HGNC=667|UniProtKB=P61586	Transforming protein RhoA	RCA	19074642	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00037	Ionotropic glutamate receptor pathway	P01001	KA4	CHICK|Ensembl=ENSGALG00000006638|UniProtKB=R4GGL9	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	MOUSE|MGI=MGI=96575|UniProtKB=P15208	Insulin receptor	ISS	14500580	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000001384|UniProtKB=F7GL73	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P05730	Endogenous cannabinoid signaling	P05751	Galpha	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00055	Transcription regulation by bZIP transcription factor	P01392	TFIIH complex	RAT|RGD=1305494|UniProtKB=Q561R7	General transcription factor IIH subunit 3	ISS			PTHR12831:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00051	TCA cycle	P01274	Succinyl CoA Synthetase	MOUSE|MGI=MGI=1927234|UniProtKB=Q9WUM5	Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial	ISS	97407896	PubMed	PTHR11117:SF2	SUCCINYL-COA LIGASE  ADP/GDP-FORMING  SUBUNIT ALPHA, MITOCHONDRIAL
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DROME|FlyBase=FBgn0259680|UniProtKB=P83099	Putative protein kinase C delta type homolog	ISS	3045562	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	ARATH|TAIR=AT5G23860|UniProtKB=P29516	Tubulin beta-8 chain	ISS	9454836	PubMed	PTHR11588:SF264	TUBULIN BETA-8 CHAIN
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00796	Kainate receptor	BOVIN|Ensembl=ENSBTAG00000034854|UniProtKB=F1N246	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04393	Ras Pathway	P04546	GSK3	HUMAN|HGNC=4616|UniProtKB=P49840	Glycogen synthase kinase-3 alpha	IDA	21361340	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00029	Huntington disease	P00780	Microtubule	TRYB2|Gene=TB927.1.2330|UniProtKB=Q4GYY6	Beta tubulin	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00018	EGF receptor signaling pathway	P00561	STAT	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	ISS	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00047	PDGF signaling pathway	P01153	GSK3	HUMAN|HGNC=4616|UniProtKB=P49840	Glycogen synthase kinase-3 alpha	ISS	12086949	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	ISS	http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00012	Cadherin signaling pathway	P00470	F-actin	DROME|FlyBase=FBgn0000045|UniProtKB=P02574	Actin, larval muscle	IC	14684598	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	DROME|FlyBase=FBgn0004168|UniProtKB=P28285	5-hydroxytryptamine receptor 2A	ISS	8143856	PubMed	PTHR24247:SF117	5-HYDROXYTRYPTAMINE RECEPTOR 2A-RELATED
P00034	Integrin signalling pathway	P00923	Arf1	BOVIN|Ensembl=ENSBTAG00000007725|UniProtKB=P84080	ADP-ribosylation factor 1	ISS	11752622	PubMed	PTHR11711:SF294	ADP-RIBOSYLATION FACTOR 3
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IDA	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	RCA	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P02738	De novo purine biosynthesis	P02891	GDP kinase	XENTR|Xenbase=XB-GENE-923233|UniProtKB=Q6AZK9	Nucleoside diphosphate kinase	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P04393	Ras Pathway	P04578	Rho	ORNAN|Ensembl=ENSOANG00000013807|UniProtKB=F7DKX6	Uncharacterized protein	ISS	10556059	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00019	Endothelin signaling pathway	P00589	Akt	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	IGI	12089061	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01123	Bcl-2	MOUSE|MGI=MGI=88138|UniProtKB=P10417	Apoptosis regulator Bcl-2	ISS	11323415	PubMed	PTHR11256:SF11	APOPTOSIS REGULATOR BCL-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	DROME|FlyBase=FBgn0004611|UniProtKB=P25455	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II	ISS	12176394	PubMed	PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00005	Angiogenesis	P00206	Wnt	TAKRU|Ensembl=ENSTRUG00000011280|UniProtKB=H2TUW3	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00010	B cell activation	P00392	I kappa B	CANLF|Ensembl=ENSCAFG00000013418|UniProtKB=E2RML9	Uncharacterized protein	ISS	10811867	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	PANTR|Ensembl=ENSPTRG00000007084|UniProtKB=H2Q9G5	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	IDA	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ASHGO|EnsemblGenome=AGOS_ABR222W|UniProtKB=Q75D00	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02724	Alanine biosynthesis	P02815	Branched chain amino acid aminotransferase	STRCO|EnsemblGenome=CAA19971|UniProtKB=O86505	Probable branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF44	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P00049	Parkinson disease	P01230	Src kinase	BOVIN|Ensembl=ENSBTAG00000020034|UniProtKB=F1N261	Tyrosine-protein kinase	ISS	1371009	PubMed	PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P00047	PDGF signaling pathway	P01169	Vav	PANTR|Ensembl=ENSPTRG00000010378|UniProtKB=H2QF58	Uncharacterized protein	ISS	14623913	PubMed	PTHR22826:SF112	PROTO-ONCOGENE VAV
P00059	p53 pathway	G01579	PTEN	DROME|FlyBase=FBgn0026379|UniProtKB=Q7KMQ6	IP16020p	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00029	Huntington disease	P00790	beta-Tubulin	CAEEL|WormBase=WBGene00006537|UniProtKB=P52275	Tubulin beta-2 chain	TAS	12932731	PubMed	PTHR11588:SF84	TUBULIN BETA-2 CHAIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P05731	GABA-B receptor II signaling	P05754	Ggamma	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00004	Alzheimer disease-presenilin pathway	P00127	APP	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00019	Endothelin signaling pathway	P00590	IP3 R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00045	Notch signaling pathway	P01109	Aph-1	CANLF|Ensembl=ENSCAFG00000011777|UniProtKB=E2R5H5	Anterior pharynx defective 1 homolog A	ISS	12471034	PubMed	PTHR12889:SF3	GAMMA-SECRETASE SUBUNIT APH-1A
P02738	De novo purine biosynthesis	P02899	GMP synthase	SCHPO|PomBase=SPAP7G5.02c|UniProtKB=Q9P772	GMP synthase [glutamine-hydrolyzing]	ISS			PTHR11922:SF2	GMP SYNTHASE  GLUTAMINE-HYDROLYZING
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MACMU|Ensembl=ENSMMUG00000019399|UniProtKB=F6QFJ6	Frizzled-6	ISS	11212302	PubMed	PTHR11309:SF75	FRIZZLED-6
P00021	FGF signaling pathway	P00629	PP2A	RAT|RGD=620919|UniProtKB=P36876	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform	IGI	137056	PubMed	PTHR11871:SF2	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IDA	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00048	PI3 kinase pathway	P01196	PDK1	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	IGI	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	HUMAN|HGNC=4586|UniProtKB=Q13224	Glutamate receptor ionotropic, NMDA 2B	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02749	Leucine biosynthesis	P03002	Isopropylmalate isomerase	BACSU|EnsemblGenome=BSU28250|UniProtKB=P94568	3-isopropylmalate dehydratase small subunit	ISS			PTHR43345:SF2	3-ISOPROPYLMALATE DEHYDRATASE SMALL SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IDA	1504106	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04568	MKK3/6	BOVIN|Ensembl=ENSBTAG00000010576|UniProtKB=A4IFH7	MAP2K3 protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P02742	Tetrahydrofolate biosynthesis	P02941	Dihydroneopterin aldolase	ARATH|TAIR=AT5G62980|UniProtKB=Q9FM54	Dihydroneopterin aldolase 2	ISS			PTHR42844:SF4	DIHYDRONEOPTERIN ALDOLASE 1-RELATED
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	MACMU|Ensembl=ENSMMUG00000017022|UniProtKB=F7HQZ9	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00010	B cell activation	P00385	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00049	Parkinson disease	P01208	Hsp70	CANLF|Ensembl=ENSCAFG00000001886|UniProtKB=H9GW49	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF239	HEAT SHOCK COGNATE 71 KDA PROTEIN
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IDA	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00029	Huntington disease	P00808	Caspase 8	PANTR|Ensembl=ENSPTRG00000012801|UniProtKB=H2QJ86	Caspase 8, apoptosis-related cysteine peptidase	ISS	11917123	PubMed	PTHR10454:SF162	CASPASE-8
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	HUMAN|HGNC=7882|UniProtKB=Q04721	Neurogenic locus notch homolog protein 2	IDA	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	HUMAN|HGNC=2451|UniProtKB=P48729	Casein kinase I isoform alpha	IDA	10617630	PubMed	PTHR11909:SF84	CASEIN KINASE I ISOFORM ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	RAT|RGD=1304887|UniProtKB=D3ZPL7	Down syndrome cell adhesion molecule-like 1 (Predicted)	ISS			PTHR44107:SF3	DOWN SYNDROME CELL ADHESION MOLECULE-LIKE PROTEIN 1
P00021	FGF signaling pathway	P00637	MKK4,7	CANLF|Ensembl=ENSCAFG00000017851|UniProtKB=F1PBB6	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000014976|UniProtKB=H2R892	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00010	B cell activation	P00373	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00010	B cell activation	P00383	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IDA	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IDA	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000000289|UniProtKB=F7A9T0	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	RCA			PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00015	Circadian clock system	P00504	Per	MOUSE|MGI=MGI=1277134|UniProtKB=O70361	Period circadian protein homolog 3	IDA	98372739	PubMed	PTHR11269:SF13	PERIOD CIRCADIAN PROTEIN HOMOLOG 3
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00029	Huntington disease	P00776	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00022	General transcription by RNA polymerase I	P00657	TBP	DROME|FlyBase=FBgn0003687|UniProtKB=P20227	TATA-box-binding protein	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00052	TGF-beta signaling pathway	P01288	FKBP12	HUMAN|HGNC=3718|UniProtKB=P26885	Peptidyl-prolyl cis-trans isomerase FKBP2	ISS			PTHR10516:SF333	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP2
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	ORNAN|Ensembl=ENSOANG00000015652|UniProtKB=F7FY70	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TAKRU|Ensembl=ENSTRUG00000018630|UniProtKB=H2VES7	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF195	BETA-CENTRACTIN
P06664	Gonadotropin-releasing hormone receptor pathway	P06831	p38	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	RCA	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04376	5HT4 type receptor mediated signaling pathway	P04431	5HT transporter	PANTR|Ensembl=ENSPTRG00000008958|UniProtKB=H2QCL1	Transporter	ISS	14653308	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=94924|UniProtKB=P61168	D(2) dopamine receptor	IDA	2137198	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	94280860	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	ANOGA|Gene=AgaP_AGAP010198|UniProtKB=Q5TNU6	Ribonucleoside-diphosphate reductase (Fragment)	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00005	Angiogenesis	P00256	PLC-gamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00005	Angiogenesis	P00187	beta catenin	HUMAN|HGNC=2514|UniProtKB=P35222	Catenin beta-1	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=4599|UniProtKB=Q14831	Metabotropic glutamate receptor 7	IDA	12351712	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00010	B cell activation	P00373	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00029	Huntington disease	P00796	Kainate receptor	BOVIN|Ensembl=ENSBTAG00000009269|UniProtKB=F1MCM2	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00056	VEGF signaling pathway	P01404	SPK	MACMU|Ensembl=ENSMMUG00000022159|UniProtKB=F6XJ72	Sphingosine kinase 2 isoform a	ISS			PTHR12358:SF40	SPHINGOSINE KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	93028473	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00018	EGF receptor signaling pathway	P00552	Ras	DICPU|Gene=DICPUDRAFT_47179|UniProtKB=F0ZI47	Putative uncharacterized protein rasB	ISS	7997267	PubMed	PTHR24070:SF206	RAS-LIKE PROTEIN RASB
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	PANTR|Ensembl=ENSPTRG00000015475|UniProtKB=H2QNI2	Protein-serine/threonine kinase	RCA			PTHR24355:SF12	RHODOPSIN KINASE
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00188	Ets	BOVIN|Ensembl=ENSBTAG00000002341|UniProtKB=A5PJG9	ETS1 protein	ISS	15579511	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01435	SWI/SNF	DROME|FlyBase=FBgn0030093|UniProtKB=Q9W384	Brahma associated protein 111kD	IDA	11532957	PubMed	PTHR13711:SF206	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY E MEMBER 1
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=107435|UniProtKB=P97326	Cadherin-6	IDA	8120095	PubMed	PTHR24027:SF322	CADHERIN-6
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	10693759	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00057	Wnt signaling pathway	P01444	Wnt	PANTR|Ensembl=ENSPTRG00000004090|UniProtKB=H2Q4F7	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00036	Interleukin signaling pathway	P00990	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02743	Formyltetrahydroformate biosynthesis	P02952	Methylene tetrahydrofolate dehydrogenase	CANLF|Ensembl=ENSCAFG00000000413|UniProtKB=F1PH90	Uncharacterized protein	ISS			PTHR43274:SF3	MONOFUNCTIONAL C1-TETRAHYDROFOLATE SYNTHASE, MITOCHONDRIAL
P05916	Opioid prodynorphin pathway	P05999	provasopressin	BOVIN|Ensembl=ENSBTAG00000008026|UniProtKB=P01175	Oxytocin-neurophysin 1	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P05916	Opioid prodynorphin pathway	P06002	G-protein	DICPU|Gene=DICPUDRAFT_93216|UniProtKB=F1A421	Guanine nucleotide-binding protein subunit beta	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00019	Endothelin signaling pathway	P00590	IP3 R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IGI	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04393	Ras Pathway	P04557	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00632	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05730	Endogenous cannabinoid signaling	P05746	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=4600|UniProtKB=O00222	Metabotropic glutamate receptor 8	IDA	12488551	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00964	p90RSK	MOUSE|MGI=MGI=1342290|UniProtKB=Q9WUT3	Ribosomal protein S6 kinase alpha-2	ISS	1922062	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00019	Endothelin signaling pathway	P00591	PLCbeta	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	IGI	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00029	Huntington disease	P00778	NMDA receptor	HUMAN|HGNC=4587|UniProtKB=Q14957	Glutamate receptor ionotropic, NMDA 2C	IDA	11319238	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MONDO|Ensembl=ENSMODG00000016960|UniProtKB=F6V5G0	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00059	p53 pathway	G01575	GADD45	MONDO|Ensembl=ENSMODG00000000788|UniProtKB=F6SSE6	Uncharacterized protein	ISS	10097101	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P02738	De novo purine biosynthesis	P02901	Adenosuccinate lyase	METAC|EnsemblGenome=MA_3971|UniProtKB=Q8TJ18	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P00048	PI3 kinase pathway	P01179	PKB	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000001583|UniProtKB=F7BBM1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Ensembl=ENSGALG00000014620|UniProtKB=F1N8P3	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00964	p90RSK	RAT|RGD=620676|UniProtKB=F1M7N7	Ribosomal protein S6 kinase	ISS	1922062	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00053	T cell activation	P01332	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	PANTR|Ensembl=ENSPTRG00000029110|UniProtKB=H2R6C6	Jun B proto-oncogene	ISS	10664585	PubMed	PTHR11462:SF37	TRANSCRIPTION FACTOR JUN-B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04407	K+ channel	MOUSE|MGI=MGI=3521816|UniProtKB=Q3LS21	Potassium channel subfamily K member 9	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	RAT|RGD=1309504|UniProtKB=D3ZRN3	Protein Actbl2	ISS	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P06664	Gonadotropin-releasing hormone receptor pathway	P06832	c-Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	RCA	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	IDA	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00029	Huntington disease	G01535	PIG3	SCHPO|PomBase=SPCC1442.16c|UniProtKB=O74489	Probable quinone oxidoreductase	TAS	12932731	PubMed	PTHR42975:SF1	QUINONE OXIDOREDUCTASE-RELATED
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IGI	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9441|UniProtKB=P51817	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	DROME|FlyBase=FBgn0263116|UniProtKB=P28286	5-hydroxytryptamine receptor 2B	IDA			PTHR24247:SF117	5-HYDROXYTRYPTAMINE RECEPTOR 2A-RELATED
P00047	PDGF signaling pathway	P01154	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANAL|CGD=CAL0068551|UniProtKB=Q5AAR9	Phosphatidylinositol 3-kinase	TAS	10870104	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	DANRE|ZFIN=ZDB-GENE-030513-3|UniProtKB=B3DJU0	Thyroid stimulating hormone, beta subunit	ISS	5101174	PubMed	PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P04393	Ras Pathway	P04579	Shc	MOUSE|MGI=MGI=98296|UniProtKB=P98083	SHC-transforming protein 1	IDA	8264585	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00006	Apoptosis signaling pathway	P00291	MEKK1	RAT|RGD=620966|UniProtKB=Q62925	Mitogen-activated protein kinase kinase kinase 1	ISS	8940199	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	PANTR|Gene=DRD2|UniProtKB=P60026	D(2) dopamine receptor	ISS	1319557	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=620308|UniProtKB=P30936	Somatostatin receptor type 3	IDA	12562507	PubMed	PTHR24229:SF42	SOMATOSTATIN RECEPTOR TYPE 3
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	PANTR|Ensembl=ENSPTRG00000020039|UniProtKB=H2R9W1	Uncharacterized protein	ISS	12135927	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00029	Huntington disease	P00774	Dynein complex	HUMAN|HGNC=2952|UniProtKB=Q96JB1	Dynein heavy chain 8, axonemal	IPI	9454836	PubMed	PTHR10676:SF344	DYNEIN HEAVY CHAIN 8, AXONEMAL
P00037	Ionotropic glutamate receptor pathway	P01001	KA4	MOUSE|MGI=MGI=95817|UniProtKB=Q8BMF5	Glutamate receptor ionotropic, kainate 4	ISS	11319238	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	DROME|FlyBase=FBgn0004619|UniProtKB=Q03445	Glutamate receptor 1	IC	8804111	PubMed	PTHR18966:SF270	GLUTAMATE RECEPTOR 1-RELATED
P00021	FGF signaling pathway	P00646	RasGAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00049	Parkinson disease	P01227	20S proteasome	CHICK|Gene=PSMA1|UniProtKB=O42265	Proteasome subunit alpha type-1	ISS	12859888	PubMed	PTHR11599:SF12	PROTEASOME SUBUNIT ALPHA TYPE-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	CANLF|Ensembl=ENSCAFG00000005415|UniProtKB=F1PQM2	Uncharacterized protein	ISS	11742073	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05918	p38 MAPK pathway	P06015	p38gamma	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	RCA	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00878	INFgamma	CHICK|Ensembl=ENSGALG00000009903|UniProtKB=P49708	Interferon gamma	TAS	11929133	PubMed	PTHR11419:SF0	INTERFERON GAMMA
P05913	Enkephalin release	P05974	G-Protein (i)	CAEEL|WormBase=WBGene00001648|UniProtKB=P51875	Guanine nucleotide-binding protein G(o) subunit alpha	IC	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00015	Circadian clock system	P00505	Cry	RAT|RGD=620935|UniProtKB=Q923I8	Cryptochrome-2	IDA	11533252	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00054	Toll receptor signaling pathway	P01358	ERK1	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	11790551	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00029	Huntington disease	P00775	Rac	RAT|RGD=1310528|UniProtKB=Q5RJS2	Protein Rhoj	ISS	12932731	PubMed	PTHR24072:SF17	RHO-RELATED GTP-BINDING PROTEIN RHOJ
P00049	Parkinson disease	P01242	Casein kinase I	ARATH|TAIR=AT2G19470|UniProtKB=Q9ZUP4	At2g19470	IDA	10617630	PubMed	PTHR11909:SF298	CASEIN KINASE 1-LIKE PROTEIN 12-RELATED
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05913	Enkephalin release	P05977	G-Protein (s)	PANTR|Ensembl=ENSPTRG00000000843|UniProtKB=H2QZN8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00030	Hypoxia response via HIF activation	P00814	P300	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	IDA	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02723	Adenine and hypoxanthine salvage pathway	P02804	Hypoxanthine phosphoribosyl transferase	DEIRA|EnsemblGenome=DR_1376|UniProtKB=Q9RUK8	Hypoxanthine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00052	TGF-beta signaling pathway	P01284	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00465	TCF/LEF	MOUSE|MGI=MGI=96770|UniProtKB=P27782	Lymphoid enhancer-binding factor 1	ISS	9039917	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P04398	p53 pathway feedback loops 2	P04665	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PLAF7|EnsemblGenome=PF14_0124|UniProtKB=Q8ILW9	Actin-2	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02748	Isoleucine biosynthesis	P02994	Branched chain amino acid aminotransferase	ORYSJ|EnsemblGenome=OS05G0558400|UniProtKB=Q6AT43	Branched-chain-amino-acid aminotransferase	ISS			PTHR42825:SF3	SUBFAMILY NOT NAMED
P02734	Chorismate biosynthesis	P02873	Shikimate dehydrogenase	DEIRA|EnsemblGenome=DR_0077|UniProtKB=Q9RY73	Shikimate 5-dehydrogenase	ISS			PTHR21089:SF9	SUBFAMILY NOT NAMED
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00018	EGF receptor signaling pathway	P00547	PP2A	ARATH|TAIR=AT5G03470|UniProtKB=O04375	Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' alpha isoform	ISS			PTHR10257:SF3	PP2A-B', ISOFORM B
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	TAS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00029	Huntington disease	P00790	beta-Tubulin	MOUSE|MGI=MGI=1920960|UniProtKB=Q9CWF2	Tubulin beta-2B chain	ISS	9454836	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CANLF|Ensembl=ENSCAFG00000012623|UniProtKB=F1PVP1	Uncharacterized protein	ISS	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00007	Axon guidance mediated by semaphorins	P00340	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00024	Glycolysis	P00678	Enolase	SULSO|EnsemblGenome=SSO0913|UniProtKB=Q97ZJ3	Enolase	IEA	21332296	PubMed	PTHR11902:SF1	ENOLASE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	2372396	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00010	B cell activation	P00371	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	HUMAN|HGNC=5287|UniProtKB=P28222	5-hydroxytryptamine receptor 1B	ISS	11701344	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	PANTR|Ensembl=ENSPTRG00000009822|UniProtKB=G2HEY4	Fibronectin 1	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00049	Parkinson disease	P01211	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00383	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00057	Wnt signaling pathway	P01431	LRP5/6	HUMAN|HGNC=6698|UniProtKB=O75581	Low-density lipoprotein receptor-related protein 6	IDA	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00045	Notch signaling pathway	P01119	NIct	HUMAN|HGNC=7883|UniProtKB=Q9UM47	Neurogenic locus notch homolog protein 3	IC	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IC	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00029	Huntington disease	P00769	N-Wasp	PANTR|Ensembl=ENSPTRG00000019640|UniProtKB=H2QVA9	Uncharacterized protein	ISS	12932731	PubMed	PTHR23202:SF39	NEURAL WISKOTT-ALDRICH SYNDROME PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	PANTR|Ensembl=ENSPTRG00000018398|UniProtKB=H2QTD1	Glycoprotein hormones alpha chain	ISS	15927770	PubMed	PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P00029	Huntington disease	P00790	beta-Tubulin	ORYSJ|EnsemblGenome=OS05G0413200|UniProtKB=Q76FS3	Tubulin beta-6 chain	TAS	12932731	PubMed	PTHR11588:SF249	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01468	APC	MOUSE|MGI=MGI=88039|UniProtKB=Q61315	Adenomatous polyposis coli protein	IDA	12549854	PubMed	PTHR12607:SF11	ADENOMATOUS POLYPOSIS COLI PROTEIN
P05918	p38 MAPK pathway	P06013	ELK	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	RCA	11050086	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	CAEBR|Gene=CBG09806|UniProtKB=A8X9P2	Clathrin heavy chain	ISS	9388255	PubMed	PTHR10292:SF1	CLATHRIN HEAVY CHAIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	SCHMA|EnsemblGenome=Smp_020170|UniProtKB=G4V8E3	Voltage-dependent calcium channel (Fragment)	ISS	14507926	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00053	T cell activation	P01298	NFkappaB	BOVIN|Ensembl=ENSBTAG00000020270|UniProtKB=F1MKW9	Uncharacterized protein	ISS	12574369	PubMed	PTHR24169:SF9	NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT
P00006	Apoptosis signaling pathway	P00321	HSP70	XENTR|Xenbase=XB-GENE-955426|UniProtKB=F6QKL0	Uncharacterized protein (Fragment)	ISS	12150907	PubMed	PTHR19375:SF239	HEAT SHOCK COGNATE 71 KDA PROTEIN
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02922	Orotate phosphoribosyltransferase	THEMA|EnsemblGenome=TM_0331|UniProtKB=Q9WYG6	Orotate phosphoribosyltransferase	ISS			PTHR19278:SF9	URIDINE 5'-MONOPHOSPHATE SYNTHASE
P00005	Angiogenesis	P00238	Ras	MONDO|Gene=KRAS|UniProtKB=Q07983	GTPase KRas	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IC	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00021	FGF signaling pathway	P00641	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00021	FGF signaling pathway	P00644	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04398	p53 pathway feedback loops 2	G04715	CYCLIN G	MOUSE|MGI=MGI=102890|UniProtKB=P51945	Cyclin-G1	ISS	7957050	PubMed	PTHR10177:SF59	CYCLIN-G1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00036	Interleukin signaling pathway	P00971	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8235613	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00046	Oxidative stress response	P01131	MKP5	BOVIN|Ensembl=ENSBTAG00000021912|UniProtKB=F1MFJ5	Dual specificity protein phosphatase	ISS			PTHR10159:SF305	DUAL SPECIFICITY PROTEIN PHOSPHATASE 7
P00018	EGF receptor signaling pathway	P00557	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IGI	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P04393	Ras Pathway	P04542	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00641	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00034	Integrin signalling pathway	P00944	Actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00029	Huntington disease	P00790	beta-Tubulin	ANOGA|EnsemblGenome=AGAP010929|UniProtKB=Q7PSI4	AGAP010929-PA	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00508	Cofilin	MOUSE|MGI=MGI=101763|UniProtKB=P45591	Cofilin-2	ISS			PTHR11913:SF15	COFILIN-2
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000008430|UniProtKB=F6VB97	Uncharacterized protein	ISS			PTHR11824:SF8	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	ARATH|TAIR=AT2G21790|UniProtKB=Q9SJ20	Ribonucleoside-diphosphate reductase large subunit	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00049	Parkinson disease	P01236	Casein kinase II	SCLS1|EnsemblGenome=SS1G_12241|UniProtKB=A7F2U3	Casein kinase II	ISS	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P05914	Nicotine degradation	P05979	FMO3	CANLF|Ensembl=ENSCAFG00000014992|UniProtKB=Q95LA1	Dimethylaniline monooxygenase [N-oxide-forming] 3	ISS			PTHR23023:SF44	DIMETHYLANILINE MONOOXYGENASE  N-OXIDE-FORMING  3
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	RAT|RGD=2734|UniProtKB=Q01812	Glutamate receptor ionotropic, kainate 4	ISS	11319238	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	4506785	gi	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=1748|UniProtKB=P12830	Cadherin-1	IDA	11953314	PubMed	PTHR24027:SF319	CADHERIN-1
P00059	p53 pathway	G04696	Siah	PANTR|Ensembl=ENSPTRG00000008094|UniProtKB=H2QB23	E3 ubiquitin-protein ligase	ISS	11389839	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00053	T cell activation	P01330	IKK	MOUSE|MGI=MGI=1338071|UniProtKB=O88351	Inhibitor of nuclear factor kappa-B kinase subunit beta	IGI	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00059	p53 pathway	P04633	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	8457205	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P05730	Endogenous cannabinoid signaling	P05746	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IC	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	RAT|RGD=620314|UniProtKB=B0LPN4	Ryanodine receptor 2	ISS	8930069	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05913	Enkephalin release	P05974	G-Protein (i)	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	DANRE|ZFIN=ZDB-GENE-030131-9435|UniProtKB=F1R8S3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00054	Toll receptor signaling pathway	P01352	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONBE|Gene=37852|UniProtKB=A9V489	Predicted protein	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00054	Toll receptor signaling pathway	P01343	IRAK1	RAT|RGD=1563841|UniProtKB=B2RYH5	Interleukin-1 receptor-associated kinase 1 (Predicted)	ISS	96279287	PubMed	PTHR24419:SF1	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1
P00005	Angiogenesis	P00236	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	IDA	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00019	Endothelin signaling pathway	P00591	PLCbeta	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	IGI	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04393	Ras Pathway	P04561	SRF	PANTR|Ensembl=ENSPTRG00000018189|UniProtKB=H2QT21	Uncharacterized protein	ISS	15647354	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P02738	De novo purine biosynthesis	P02899	GMP synthase	CHICK|Ensembl=ENSGALG00000010284|UniProtKB=F1NAQ8	Uncharacterized protein	ISS			PTHR11922:SF2	GMP SYNTHASE  GLUTAMINE-HYDROLYZING
P04398	p53 pathway feedback loops 2	P04668	p53	MACMU|Ensembl=ENSMMUG00000016466|UniProtKB=F7GBH1	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	HUMAN|HGNC=4545|UniProtKB=P43250	G protein-coupled receptor kinase 6	IDA	12032308	PubMed	PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P00010	B cell activation	P00373	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00562	p38	CAEBR|Gene=CBG01555|UniProtKB=A8WRD7	Mitogen-activated protein kinase	ISS	22138445	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=108071|UniProtKB=P70701	Protein Wnt-10a	IDA	8717036	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00019	Endothelin signaling pathway	P00566	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IGI	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	MOUSE|MGI=MGI=1351342|UniProtKB=Q3UVX5	Metabotropic glutamate receptor 5	ISS	12488551	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00034	Integrin signalling pathway	P00912	Arp2/3	RAT|RGD=1311791|UniProtKB=Q4KLF8	Actin-related protein 2/3 complex subunit 5	ISS	9230079	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00057	Wnt signaling pathway	P01429	Axin	HUMAN|HGNC=903|UniProtKB=O15169	Axin-1	IDA	12549854	PubMed	PTHR10845:SF11	AXIN-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	YARLI|EnsemblGenome=YALI0_D08272g|UniProtKB=Q9UVF3	Actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05731	GABA-B receptor II signaling	P05754	Ggamma	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	RCA	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IDA	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	IDA	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000035697|UniProtKB=Q28024	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IDA	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00054	Toll receptor signaling pathway	P01367	MKK3	ORNAN|Ensembl=ENSOANG00000007732|UniProtKB=F6PXH5	Uncharacterized protein (Fragment)	ISS	11971971	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00029	Huntington disease	P00807	Actin	HUMAN|HGNC=144|UniProtKB=P63261	Actin, cytoplasmic 2	IDA	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00053	T cell activation	P01294	NFAT	PANTR|Ensembl=ENSPTRG00000008260|UniProtKB=H2QBD7	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	ISS	12787506	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P05913	Enkephalin release	P05977	G-Protein (s)	SCLS1|EnsemblGenome=SS1G_03482|UniProtKB=A7EDU2	Guanine nucleotide-binding protein beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	BOVIN|Ensembl=ENSBTAG00000016341|UniProtKB=Q3T0T8	Regulator of G-protein signaling 5	ISS	8756726	PubMed	PTHR10845:SF42	REGULATOR OF G-PROTEIN SIGNALING 5
P00034	Integrin signalling pathway	P00922	Collagen	PANTR|Ensembl=ENSPTRG00000034541|UniProtKB=H2RD92	Collagen, type VIII, alpha 1	ISS	10778855	PubMed	PTHR44057:SF2	COLLAGEN ALPHA-1 VIII  CHAIN
P00005	Angiogenesis	P00218	STAT1	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	ISS	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00029	Huntington disease	G01533	Bax	HUMAN|HGNC=959|UniProtKB=Q07812	Apoptosis regulator BAX	ISS	8358790	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	PANTR|Ensembl=ENSPTRG00000024326|UniProtKB=H2R231	Uncharacterized protein	ISS	12968034	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00035	Interferon-gamma signaling pathway	P00961	STAT1	DANRE|ZFIN=ZDB-GENE-980526-499|UniProtKB=Q6P943	Signal transducer and activator of transcription	TAS	99348060	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P02751	Lysine biosynthesis	P03008	Dihydrodipicolinate synthase	AQUAE|EnsemblGenome=aq_1143|UniProtKB=O67216	4-hydroxy-tetrahydrodipicolinate synthase	ISS			PTHR12128:SF15	4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL
P00048	PI3 kinase pathway	P01188	Gbetagamma	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00898	FKHR	MACMU|Ensembl=ENSMMUG00000020369|UniProtKB=F6UMX8	Uncharacterized protein	ISS	12884295	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00053	T cell activation	P01312	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00005	Angiogenesis	P00184	Src	MACMU|Ensembl=ENSMMUG00000020131|UniProtKB=F7FWN4	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MACMU|Ensembl=ENSMMUG00000001661|UniProtKB=F7GR69	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	RAT|RGD=2917|UniProtKB=P15127	Insulin receptor	ISS	2983222	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P00054	Toll receptor signaling pathway	P01368	MKK2	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=4598|UniProtKB=O15303	Metabotropic glutamate receptor 6	IDA	12488551	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00010	B cell activation	P00402	Jnk	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00006	Apoptosis signaling pathway	P00318	PKCs	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00047	PDGF signaling pathway	P01159	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	PANTR|Ensembl=ENSPTRG00000009001|UniProtKB=H2QCN4	C-C motif chemokine	ISS			PTHR12015:SF146	EOTAXIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	RAT|RGD=2848|UniProtKB=P08909	5-hydroxytryptamine receptor 2C	IDA			PTHR24247:SF32	5-HYDROXYTRYPTAMINE RECEPTOR 2C
P00021	FGF signaling pathway	P00643	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05915	Opioid proenkephalin pathway	P05990	K+ channel	HUMAN|HGNC=6278|UniProtKB=O14649	Potassium channel subfamily K member 3	ISS	11875121	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05731	GABA-B receptor II signaling	P05752	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01023	CaMKII	MOUSE|MGI=MGI=88259|UniProtKB=Q923T9	Calcium/calmodulin-dependent protein kinase type II subunit gamma	ISS	12888804	PubMed	PTHR43940:SF7	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT GAMMA
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	DROME|FlyBase=FBgn0001991|UniProtKB=Q24270	Voltage-dependent calcium channel type D subunit alpha-1	ISS	10514528	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	LEIMA|EnsemblGenome=LmjF.04.1230|UniProtKB=Q9U1E8	Actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	RAT|RGD=70958|UniProtKB=P19492	Glutamate receptor 3	ISS	12941441	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	PANTR|Ensembl=ENSPTRG00000018764|UniProtKB=H2QU01	Uncharacterized protein	ISS	6382022	PubMed	PTHR15071:SF17	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	176910	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04398	p53 pathway feedback loops 2	P04668	p53	MACMU|Ensembl=ENSMMUG00000008639|UniProtKB=P56424	Cellular tumor antigen p53	TAS	11313951	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DROME|FlyBase=FBgn0000044|UniProtKB=P53501	Actin-57B	ISS	10974003	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00006	Apoptosis signaling pathway	P00314	MKK3	RAT|RGD=1306620|UniProtKB=B1H230	Map2k3 protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	BOVIN|Ensembl=ENSBTAG00000011723|UniProtKB=E1BKL6	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CIOIN|Ensembl=ENSCING00000000848|UniProtKB=F6SCP4	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ORYSJ|EnsemblGenome=OS07G0691800|UniProtKB=P46466	26S protease regulatory subunit 4 homolog	ISS			PTHR23073:SF24	26S PROTEASE REGULATORY SUBUNIT 4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IGI	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	DAPPU|EnsemblGenome=DAPPUDRAFT_306746|UniProtKB=E9GYE9	Putative uncharacterized protein	ISS			PTHR24072:SF192	CDC42 HOMOLOG
P04395	Vasopressin synthesis	P04596	Endo Peptidase	CANLF|Ensembl=ENSCAFG00000002543|UniProtKB=F6UU49	Uncharacterized protein	ISS			PTHR11757:SF12	PROLYL ENDOPEPTIDASE-LIKE
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	XENTR|Xenbase=XB-GENE-961764|UniProtKB=F6W3Y0	Uncharacterized protein	ISS	11259591	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00029	Huntington disease	P00805	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04397	p53 pathway by glucose deprivation	P04641	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01275	P38	DROME|FlyBase=FBgn0024846|UniProtKB=O61443	Mitogen-activated protein kinase 14B	TAS	10851062	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01307	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IPI	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04393	Ras Pathway	P04548	ATF2	PANTR|Ensembl=ENSPTRG00000012660|UniProtKB=H2QJ07	Activating transcription factor 2	ISS	15218628	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P06664	Gonadotropin-releasing hormone receptor pathway	G06673	CGA	MOUSE|MGI=MGI=88390|UniProtKB=P01216	Glycoprotein hormones alpha chain	RCA	89325834	PubMed	PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	MACMU|Ensembl=ENSMMUG00000010987|UniProtKB=F7GCX9	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00059	p53 pathway	G01579	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	IC	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	DROME|FlyBase=FBgn0000319|UniProtKB=P29742	Clathrin heavy chain	IDA	9388255	PubMed	PTHR10292:SF1	CLATHRIN HEAVY CHAIN
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	IDA	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00056	VEGF signaling pathway	P01407	Erk	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IDA	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01168	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	IDA	97102675	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00056	VEGF signaling pathway	P01414	PLC-gamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	ISS	14698601	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00020	FAS signaling pathway	P00599	Caspase3	TAKRU|Ensembl=ENSTRUG00000015915|UniProtKB=H2UUR6	Uncharacterized protein (Fragment)	IGI	9323209	PubMed	PTHR10454:SF198	CASPASE-3
P00049	Parkinson disease	P01238	14-3-3	CHICK|Ensembl=ENSGALG00000004143|UniProtKB=Q5ZLQ6	14-3-3 protein beta/alpha	ISS	91108808	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CANLF|Gene=GRIN1|UniProtKB=Q5R1P0	Glutamate receptor ionotropic, NMDA 1	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00053	T cell activation	P01294	NFAT	BOVIN|Ensembl=ENSBTAG00000004368|UniProtKB=F1MSU2	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P06664	Gonadotropin-releasing hormone receptor pathway	P06803	Rap1b	MOUSE|MGI=MGI=894315|UniProtKB=Q99JI6	Ras-related protein Rap-1b	RCA	10476970	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00519	ROCK	MOUSE|MGI=MGI=107927|UniProtKB=P70335	Rho-associated protein kinase 1	ISS	10779382	PubMed	PTHR22988:SF33	RHO-ASSOCIATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05915	Opioid proenkephalin pathway	P05994	G-protein	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00005	Angiogenesis	P00183	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	10982827	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00046	Oxidative stress response	P01131	MKP5	MACMU|Ensembl=ENSMMUG00000019805|UniProtKB=F7G1T6	Dual specificity protein phosphatase 18	ISS			PTHR10159:SF313	DUAL SPECIFICITY PROTEIN PHOSPHATASE 18
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P02766	Phenylethylamine degradation	P03103	Phenylethylamine oxidase	PANTR|Ensembl=ENSPTRG00000030952|UniProtKB=H2R9Q9	Amine oxidase	ISS			PTHR10638:SF23	MEMBRANE PRIMARY AMINE OXIDASE
P00052	TGF-beta signaling pathway	P01284	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00012	Cadherin signaling pathway	P00470	F-actin	RAT|RGD=2025|UniProtKB=P68136	Actin, alpha skeletal muscle	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00036	Interleukin signaling pathway	P00964	p90RSK	MACMU|Ensembl=ENSMMUG00000022111|UniProtKB=F7H7W3	Ribosomal protein S6 kinase	ISS	15226426	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=11331|UniProtKB=P30874	Somatostatin receptor type 2	IDA	12441358	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P00019	Endothelin signaling pathway	P00590	IP3 R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	IGI	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00047	PDGF signaling pathway	P01174	Rho	PANTR|Ensembl=ENSPTRG00000012510|UniProtKB=H2QIS7	Uncharacterized protein	ISS	8288572	PubMed	PTHR23181:SF5	RHO GTPASE-ACTIVATING PROTEIN 15
P04393	Ras Pathway	P04559	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12874273	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00236	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	G01535	PIG3	CHICK|Ensembl=ENSGALG00000011361|UniProtKB=F1P4I0	Uncharacterized protein	TAS	12932731	PubMed	PTHR44154:SF1	QUINONE OXIDOREDUCTASE
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	HUMAN|HGNC=6692|UniProtKB=Q07954	Prolow-density lipoprotein receptor-related protein 1	IDA	11907044	PubMed	PTHR44025:SF2	PROLOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1
P02751	Lysine biosynthesis	P03009	Aspartokinase	AQUAE|EnsemblGenome=aq_1152|UniProtKB=O67221	Aspartokinase	ISS			PTHR21499:SF3	ASPARTOKINASE
P00049	Parkinson disease	P01238	14-3-3	CANLF|Ensembl=ENSCAFG00000014869|UniProtKB=E2REA4	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P00021	FGF signaling pathway	P00637	MKK4,7	PANTR|Ensembl=ENSPTRG00000008783|UniProtKB=H2QCA7	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04393	Ras Pathway	P04567	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05760	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P02727	Androgen/estrogene/progesterone biosynthesis	P02829	Cholesterol acyltransferase	MACMU|Ensembl=ENSMMUG00000020339|UniProtKB=F6WG29	O-acyltransferase	ISS	9756918	PubMed	PTHR10408:SF10	STEROL O-ACYLTRANSFERASE 2
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05731	GABA-B receptor II signaling	P05760	AC	HUMAN|HGNC=239|UniProtKB=P40145	Adenylate cyclase type 8	RCA	12890691	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	PANTR|Ensembl=ENSPTRG00000009871|UniProtKB=H2QE95	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	BRADU|Gene=BAC47349|UniProtKB=H7C6P8	Blr2084 protein	ISS			PTHR43785:SF1	TYPE-1 GLUTAMINE SYNTHETASE 2
P00053	T cell activation	P01311	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	14765990	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=12785|UniProtKB=Q9Y6F9	Protein Wnt-6	IDA	8717036	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P04392	P53 pathway feedback loops 1	P04536	Mdm2	MACMU|Ensembl=ENSMMUG00000014193|UniProtKB=F7AKR9	Uncharacterized protein	ISS	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IC	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ARATH|TAIR=AT5G41990|UniProtKB=Q944Q0	Serine/threonine-protein kinase WNK8	IDA			PTHR13902:SF107	SERINE/THREONINE-PROTEIN KINASE WNK2-RELATED
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00036	Interleukin signaling pathway	P00965	ERK	PANTR|Ensembl=ENSPTRG00000020224|UniProtKB=H2Q9G3	Mitogen-activated protein kinase 6	ISS	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00036	Interleukin signaling pathway	P00967	c-fos	PANTR|Ensembl=ENSPTRG00000006553|UniProtKB=A5A6H0	C-fos	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	10644715	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00053	T cell activation	P01319	PAK	RAT|RGD=3251|UniProtKB=Q62829	Serine/threonine-protein kinase PAK 3	IDA	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00004	Alzheimer disease-presenilin pathway	P00144	Ire-1	SCHPO|PomBase=SPAC167.01|UniProtKB=O94537	Serine/threonine-protein kinase ppk4	IDA	10619423	PubMed	PTHR13954:SF6	INOSITOL-REQUIRING ENZYME-1
P04398	p53 pathway feedback loops 2	P04657	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	SCHPO|PomBase=SPAC8C9.03|UniProtKB=P36600	cAMP-dependent protein kinase regulatory subunit	ISS	88234494	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ORYSJ|EnsemblGenome=OS03G0285800|UniProtKB=Q10N20	Mitogen-activated protein kinase 5	ISS	10527417	PubMed	PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00034	Integrin signalling pathway	P00916	Ras	CAEEL|WormBase=WBGene00002335|UniProtKB=P22981	Ras protein let-60	IPI	12024031	PubMed	PTHR24070:SF385	GTPASE HRAS
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MOUSE|MGI=MGI=87904|UniProtKB=P60710	Actin, cytoplasmic 1	IC	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04393	Ras Pathway	P04572	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01155	Jak	PANTR|Ensembl=ENSPTRG00000000825|UniProtKB=H2PZ66	Tyrosine-protein kinase	ISS	9637709	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00006	Apoptosis signaling pathway	P00260	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00029	Huntington disease	P00778	NMDA receptor	CANLF|Ensembl=ENSCAFG00000013148|UniProtKB=Q5R1P3	Glutamate receptor ionotropic, NMDA 2B	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	CAEBR|Gene=CBG05858|UniProtKB=A8X1H0	Protein CBR-EGL-19 (Fragment)	ISS			PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04541	p90RSK	CANLF|Ensembl=ENSCAFG00000000828|UniProtKB=F6UWI0	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00057	Wnt signaling pathway	P01438	PP2A	TAKRU|Ensembl=ENSTRUG00000008018|UniProtKB=H2T5N4	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00050	Plasminogen activating cascade	P01254	pro-MMP-13	PANTR|Ensembl=ENSPTRG00000004222|UniProtKB=H2Q4N4	Uncharacterized protein	ISS	98180967	PubMed	PTHR10201:SF165	COLLAGENASE 3
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	MOUSE|MGI=MGI=88274|UniProtKB=P26231	Catenin alpha-1	TAS	9362521	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00005	Angiogenesis	P00203	Erk	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00054	Toll receptor signaling pathway	P01369	MKK1	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	MOUSE|MGI=MGI=95814|UniProtKB=Q60934	Glutamate receptor ionotropic, kainate 1	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02736	Coenzyme A biosynthesis	P02883	Pantothenoylcysteine decarboxylase	STRCO|Gene=CAD55280|UniProtKB=Q8CK27	Putative flavoprotein homologue (Partial)	ISS			PTHR14359:SF6	PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06739	MEK1/2	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	RCA	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DICDI|dictyBase=DDB_G0274383|UniProtKB=Q8MLZ3	cGMP-dependent 3',5'-cGMP phosphodiesterase A	IC	91298951	PubMed	PTHR45452:SF1	SUBFAMILY NOT NAMED
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MACMU|Ensembl=ENSMMUG00000010266|UniProtKB=F6PV18	Uncharacterized protein	ISS	14500986	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00001	Adrenaline and noradrenaline biosynthesis	P00066	DOPA decarb.	PANTR|Ensembl=ENSPTRG00000019189|UniProtKB=H2QUK8	Uncharacterized protein	ISS	107930	OMIM	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00005	Angiogenesis	P00237	FRP	MACMU|Ensembl=ENSMMUG00000022114|UniProtKB=F7H7V5	Uncharacterized protein	ISS	12549854	PubMed	PTHR11309:SF81	FRIZZLED-1
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	9395335	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00046	Oxidative stress response	P01131	MKP5	HUMAN|HGNC=3070|UniProtKB=Q13115	Dual specificity protein phosphatase 4	TAS			PTHR10159:SF111	DUAL SPECIFICITY PROTEIN PHOSPHATASE 4
P02721	ATP synthesis	P02797	ATP synthetase F0	HUMAN|HGNC=7414|UniProtKB=P00846	ATP synthase subunit a	TAS	15467980	PubMed	PTHR11410:SF0	ATP SYNTHASE SUBUNIT A
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00922	Collagen	PANTR|Ensembl=ENSPTRG00000002579|UniProtKB=H2R296	Uncharacterized protein	ISS	10778855	PubMed	PTHR44988:SF1	COLLAGEN ALPHA-1 XIII  CHAIN
P02738	De novo purine biosynthesis	P02889	dGDP kinase	ARATH|TAIR=AT5G63310|UniProtKB=O64903	Nucleoside diphosphate kinase II, chloroplastic	ISS			PTHR11349:SF44	NUCLEOSIDE DIPHOSPHATE KINASE II, CHLOROPLASTIC
P02756	N-acetylglucosamine metabolism	P03041	Glucosamine-6-phosphate deaminase	MACMU|Ensembl=ENSMMUG00000009770|UniProtKB=F6ZHX4	Glucosamine-6-phosphate isomerase	ISS			PTHR11280:SF8	GLUCOSAMINE-6-PHOSPHATE ISOMERASE 1
P00059	p53 pathway	P01486	Akt	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	TAS	12655147	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ANOGA|EnsemblGenome=AGAP001676|UniProtKB=Q7PXZ8	AGAP001676-PA	IDA	10974003	PubMed	PTHR11937:SF368	ACTIN, INDIRECT FLIGHT MUSCLE
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06769	Gbeta	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00021	FGF signaling pathway	P00627	ERK1-2	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00018	EGF receptor signaling pathway	P00549	EGF	CHICK|Ensembl=ENSGALG00000000949|UniProtKB=Q9W7C5	Proheparin-binding EGF-like growth factor	IGI	99254107	PubMed	PTHR10740:SF4	PROHEPARIN-BINDING EGF-LIKE GROWTH FACTOR
P05917	Opioid proopiomelanocortin pathway	P06007	alpha-MSH	DANRE|ZFIN=ZDB-GENE-030513-2|UniProtKB=Q7ZT18	Pro-opiomelanocortin protein	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IGI	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04392	P53 pathway feedback loops 1	G04683	Cop-1	HUMAN|HGNC=17440|UniProtKB=Q8NHY2	E3 ubiquitin-protein ligase RFWD2	IDA	15103385	PubMed	PTHR44080:SF1	E3 UBIQUITIN-PROTEIN LIGASE RFWD2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	TAS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05913	Enkephalin release	P05972	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P02788	Xanthine and guanine salvage pathway	P03248	Deoxyguanosine phosphorylase	BOVIN|Ensembl=ENSBTAG00000012317|UniProtKB=P55859	Purine nucleoside phosphorylase	ISS	9585525	PubMed	PTHR11904:SF12	PURINE NUCLEOSIDE PHOSPHORYLASE
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	CANLF|Ensembl=ENSCAFG00000005415|UniProtKB=F1PQM2	Uncharacterized protein	ISS	9388255	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00034	Integrin signalling pathway	P00910	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12162872	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00058	mRNA splicing	P01473	U6	BOVIN|Gene=PRPF3|UniProtKB=Q2KIA6	U4/U6 small nuclear ribonucleoprotein Prp3	ISS	9328476	PubMed	PTHR14212:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	DROME|FlyBase=FBgn0000150|UniProtKB=P08879	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00021	FGF signaling pathway	P00629	PP2A	MACMU|Ensembl=ENSMMUG00000000186|UniProtKB=F7ANY1	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P00036	Interleukin signaling pathway	P00990	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IC	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00630	RKIP	BOVIN|Ensembl=ENSBTAG00000018115|UniProtKB=P13696	Phosphatidylethanolamine-binding protein 1	ISS	92031654	PubMed	PTHR11362:SF28	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05917	Opioid proopiomelanocortin pathway	P06010	proopiomelanocortin	XENTR|Xenbase=XB-GENE-483703|UniProtKB=Q5M8F2	Proopiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00005	Angiogenesis	P00238	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00011	Blood coagulation	P00425	ZPI	MACMU|Ensembl=ENSMMUG00000007307|UniProtKB=F7F6Y0	Uncharacterized protein	ISS	7705879	gi	PTHR11461:SF191	PROTEIN Z-DEPENDENT PROTEASE INHIBITOR
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	10514528	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00053	T cell activation	P01316	MHC-antigen	BOVIN|Ensembl=ENSBTAG00000012451|UniProtKB=Q58DW7	MHC class II antigen	IPI	3112582	PubMed	PTHR19944:SF65	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DM BETA CHAIN
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04395	Vasopressin synthesis	P04589	Signal Peptidase	CAEEL|WormBase=WBGene00019679|UniProtKB=P34525	Probable signal peptidase complex subunit 3	IC	2092035	PubMed	PTHR12804:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 3
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	15737619	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00011	Blood coagulation	P00418	Fibrin monomer	MACMU|Ensembl=ENSMMUG00000021302|UniProtKB=F6UZ87	Uncharacterized protein	ISS	223002	gi	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P05731	GABA-B receptor II signaling	P05755	Gbeta	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04393	Ras Pathway	P04548	ATF2	PANTR|Ensembl=ENSPTRG00000012660|UniProtKB=H2QJ07	Activating transcription factor 2	ISS	7875593	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-478663|UniProtKB=F7EG64	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	ISS	12049732	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00056	VEGF signaling pathway	P01402	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	RCA			PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	ISS	10799299	PubMed	PTHR10048:SF14	PI-3 KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	YEAST|SGD=S000000058|UniProtKB=P39708	NADP-specific glutamate dehydrogenase 2	ISS			PTHR43571:SF1	NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED
P00005	Angiogenesis	P00205	GAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00019	Endothelin signaling pathway	P00586	Gq	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	9009705	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CAEEL|WormBase=WBGene00000064|UniProtKB=P10984	Actin-2	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04393	Ras Pathway	P04557	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01021	Vglut	CANLF|Ensembl=ENSCAFG00000006786|UniProtKB=E2RDG5	Uncharacterized protein	ISS	12815758	PubMed	PTHR11662:SF207	VESICULAR GLUTAMATE TRANSPORTER 3
P00005	Angiogenesis	P00193	SOS-1	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00049	Parkinson disease	P01227	20S proteasome	DROME|FlyBase=FBgn0004066|UniProtKB=P22769	Proteasome subunit alpha type-7-1	ISS	12859888	PubMed	PTHR11599:SF15	PROTEASOME SUBUNIT ALPHA TYPE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CAEEL|WormBase=WBGene00001188|UniProtKB=G5EG05	Uncharacterized protein	TAS	11266476	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P05913	Enkephalin release	G06046	preproenkephalin mRNA	PANTR|Ensembl=ENSPTRG00000020270|UniProtKB=H2QW70	Proenkephalin	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	MONDO|Ensembl=ENSMODG00000009937|UniProtKB=F6R812	Uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=2136744|UniProtKB=E9Q5G2	Protein Pcdhb9	IDA	8120095	PubMed	PTHR24028:SF239	PROTEIN PCDHB9
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P02722	Acetate utilization	P02802	Phosphate acetyltransferase	BACSU|EnsemblGenome=BSU37660|UniProtKB=P39646	Phosphate acetyltransferase	ISS			PTHR43356:SF3	PHOSPHATE ACETYLTRANSFERASE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MOUSE|MGI=MGI=95821|UniProtKB=Q01097	Glutamate receptor ionotropic, NMDA 2B	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00015	Circadian clock system	G01501	cry	ORNAN|Ensembl=ENSOANG00000005350|UniProtKB=F6X852	Uncharacterized protein	ISS	10428031	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00047	PDGF signaling pathway	P01162	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	PANTR|Ensembl=ENSPTRG00000017974|UniProtKB=H2QSN4	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00057	Wnt signaling pathway	P01452	NFAT	PANTR|Ensembl=ENSPTRG00000008260|UniProtKB=H2QBD7	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	ISS	9133421	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00005	Angiogenesis	P00187	beta catenin	DANRE|ZFIN=ZDB-GENE-040426-2575|UniProtKB=E7FC99	Uncharacterized protein	ISS			PTHR23315:SF68	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01428	Frizzled	CANLF|Ensembl=ENSCAFG00000013547|UniProtKB=E2QVP7	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF126	FRIZZLED-5
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CAEBR|Gene=CBG02401|UniProtKB=A8WUE7	Protein CBR-NMR-1	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00010	B cell activation	P00402	Jnk	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00648	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	15572354	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04393	Ras Pathway	P04570	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IDA	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	BRAFL|Gene=BRAFLDRAFT_124869|UniProtKB=C3ZEW0	Putative uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF263	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00645	Rac	ENTHI|EnsemblGenome=EHI_181250|UniProtKB=C4M5Z7	Rho family GTPase	ISS	12932731	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00008	Axon guidance mediated by Slit/Robo	P00346	Sdf1	HUMAN|HGNC=10672|UniProtKB=P48061	Stromal cell-derived factor 1	ISS			PTHR18837:SF3	STROMAL CELL-DERIVED FACTOR 1
P00018	EGF receptor signaling pathway	G01511	SPRY	MACMU|Ensembl=ENSMMUG00000014175|UniProtKB=F7ALK4	Uncharacterized protein	ISS	99264295	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P00048	PI3 kinase pathway	P01199	Galpha	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS			PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00004	Alzheimer disease-presenilin pathway	P00163	Erb-B4 C-terminal fragment	HUMAN|HGNC=3432|UniProtKB=Q15303	Receptor tyrosine-protein kinase erbB-4	IDA	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=1930705|UniProtKB=P61264	Syntaxin-1B	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00029	Huntington disease	P00774	Dynein complex	DROME|Gene=Dmel_CG3723|UniProtKB=A0A0B4KHJ4	Dynein heavy chain at 93AB, isoform C	IPI	9454836	PubMed	PTHR10676:SF347	DYNEIN HEAVY CHAIN AT 93AB, ISOFORM C
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MACMU|Ensembl=ENSMMUG00000014754|UniProtKB=F7G124	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF721	MYOSIN-6
P00029	Huntington disease	P00780	Microtubule	XENTR|Xenbase=XB-GENE-969447|UniProtKB=Q0IIR4	Tubulin, beta 2C	ISS	9454836	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00029	Huntington disease	P00776	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	HUMAN|HGNC=17780|UniProtKB=Q562R1	Beta-actin-like protein 2	ISS	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P02738	De novo purine biosynthesis	P02891	GDP kinase	PANTR|Ensembl=ENSPTRG00000001655|UniProtKB=H2Q0K0	Non-metastatic cells 7, protein expressed in (Nucleoside-diphosphate kinase)	ISS			PTHR43109:SF2	NUCLEOSIDE DIPHOSPHATE KINASE 7
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	SCHPO|PomBase=SPAC6G9.11|UniProtKB=Q92356	Synaptobrevin homolog 1	IC			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IC	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00018	EGF receptor signaling pathway	P00548	RKIP	ANOGA|EnsemblGenome=AGAP012962|UniProtKB=F5HM75	AGAP012962-PA	ISS			PTHR11362:SF28	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8698|UniProtKB=Q9Y5H2	Protocadherin gamma-A11	IDA	8120095	PubMed	PTHR24028:SF84	PROTOCADHERIN GAMMA-A11
P00029	Huntington disease	P00787	MAPKK4	MOUSE|MGI=MGI=1346869|UniProtKB=P47809	Dual specificity mitogen-activated protein kinase kinase 4	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00034	Integrin signalling pathway	P00936	PI3K	CANAL|CGD=CAL0068551|UniProtKB=Q5AAR9	Phosphatidylinositol 3-kinase	IC	20330542	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	TAS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12880387	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00047	PDGF signaling pathway	P01152	RasGAP	HUMAN|HGNC=9872|UniProtKB=Q15283	Ras GTPase-activating protein 2	ISS	20475167	gi	PTHR10194:SF21	RAS GTPASE-ACTIVATING PROTEIN 2
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	2837282	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	TAKRU|Ensembl=ENSTRUG00000016241|UniProtKB=H2UX35	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF305	PROTEIN KINASE C
P00049	Parkinson disease	P01227	20S proteasome	HUMAN|HGNC=9537|UniProtKB=P20618	Proteasome subunit beta type-1	ISS	12859888	PubMed	PTHR11599:SF59	PROTEASOME SUBUNIT BETA TYPE-1
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04657	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MACMU|Ensembl=ENSMMUG00000019807|UniProtKB=F7G1B1	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF179	REGULATOR OF G-PROTEIN SIGNALING 14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IDA			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00034	Integrin signalling pathway	P00912	Arp2/3	PANTR|Ensembl=ENSPTRG00000033819|UniProtKB=H2QV00	Actin related protein 2/3 complex, subunit 1A, 41kDa	ISS	12932731	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	12885769	PubMed	PTHR10202:SF13	PRESENILIN-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04452	proopiomelanocortin	DANRE|ZFIN=ZDB-GENE-041014-294|UniProtKB=Q5SPP4	Uncharacterized protein	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00059	p53 pathway	P04635	Sumo-1 ligase	DANRE|ZFIN=ZDB-GENE-040718-426|UniProtKB=Q6DI05	Small ubiquitin-related modifier 3	ISS			PTHR10562:SF50	SMALL UBIQUITIN-RELATED MODIFIER 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MACMU|Ensembl=ENSMMUG00000001672|UniProtKB=F7G3M7	Uncharacterized protein	ISS	12193720	PubMed	PTHR10845:SF32	REGULATOR OF G-PROTEIN SIGNALING 13
P06959	CCKR signaling map	P07140	PKCtheta	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	RCA	12431789	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P06959	CCKR signaling map	G07002	VMAT2	HUMAN|HGNC=10935|UniProtKB=Q05940	Synaptic vesicular amine transporter	RCA	17442673	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00030	Hypoxia response via HIF activation	P00817	TOR	PANTR|Ensembl=ENSPTRG00000000142|UniProtKB=H2PY03	Uncharacterized protein	ISS	8662507	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00034	Integrin signalling pathway	P00951	Jnk	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00059	p53 pathway	P04630	PP2A	STRPU|EnsemblGenome=SPU_025182|UniProtKB=W4ZAK5	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=8153|UniProtKB=P41143	Delta-type opioid receptor	IDA	11259487	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00005	Angiogenesis	P00254	GTPase	ASHGO|EnsemblGenome=AGOS_ABR183W|UniProtKB=Q9HF54	GTP-binding protein RHO1	ISS			PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	XENTR|Xenbase=XB-GENE-490883|UniProtKB=Q6NVA9	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00034	Integrin signalling pathway	P00912	Arp2/3	CANLF|Ensembl=ENSCAFG00000015081|UniProtKB=E2RMT4	Uncharacterized protein	ISS	12473693	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00053	T cell activation	P01311	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00024	Glycolysis	P00677	Hexokinase	MACMU|Ensembl=ENSMMUG00000015302|UniProtKB=F6Q724	Uncharacterized protein	ISS	11835228	PubMed	PTHR19443:SF10	HEXOKINASE-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	BOVIN|Ensembl=ENSBTAG00000010576|UniProtKB=A4IFH7	MAP2K3 protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	DROME|FlyBase=FBgn0026439|UniProtKB=O77062	Excitatory amino acid transporter 1, isoform A	ISS	94365697	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P00054	Toll receptor signaling pathway	P01375	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00017	DNA replication	P00529	RFC	MOUSE|MGI=MGI=2146571|UniProtKB=Q99J62	Replication factor C subunit 4	RCA			PTHR11669:SF20	REPLICATION FACTOR C SUBUNIT 4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	IC	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00034	Integrin signalling pathway	P00941	Integrin alpha	DROME|FlyBase=FBgn0034880|UniProtKB=Q9W1M8	Integrin alpha-PS5	IPI	3487386	PubMed	PTHR23220:SF83	INTEGRIN ALPHA-PS3-RELATED
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00034	Integrin signalling pathway	P00951	Jnk	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	MONDO|Ensembl=ENSMODG00000016960|UniProtKB=F6V5G0	Uncharacterized protein	ISS	20012997	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-040426-2427|UniProtKB=F1Q6C0	Uncharacterized protein (Fragment)	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00790	beta-Tubulin	PANTR|Ensembl=ENSPTRG00000008496|UniProtKB=H2QBS3	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00029	Huntington disease	P00778	NMDA receptor	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	IDA	11554549	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04393	Ras Pathway	P04559	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00012	Cadherin signaling pathway	P00475	Frizzled	XENTR|Xenbase=XB-GENE-484322|UniProtKB=F6RPG1	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF22	FRIZZLED-3
P00049	Parkinson disease	P01211	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00006	Apoptosis signaling pathway	P00269	MAPK	ORYSJ|EnsemblGenome=OS03G0285800|UniProtKB=Q10N20	Mitogen-activated protein kinase 5	ISS	10851062	PubMed	PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00024	Glycolysis	P00679	Aldolase	MONDO|Ensembl=ENSMODG00000015696|UniProtKB=F7E0Q7	Fructose-bisphosphate aldolase	ISS	3391172	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00006	Apoptosis signaling pathway	P00260	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04567	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00046	Oxidative stress response	P01135	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	TAS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CHICK|Ensembl=ENSGALG00000009621|UniProtKB=P60706	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00059	p53 pathway	P04630	PP2A	DANRE|ZFIN=ZDB-GENE-040426-877|UniProtKB=F1Q6Z7	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00009	Axon guidance mediated by netrin	P00366	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00796	Kainate receptor	CHICK|Ensembl=ENSGALG00000015835|UniProtKB=F1NZT2	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00047	PDGF signaling pathway	P01168	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	YEAST|SGD=S000005854|UniProtKB=P33328	Synaptobrevin homolog 2	ISS	8011337	PubMed	PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P04393	Ras Pathway	P04556	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TAKRU|Ensembl=ENSTRUG00000014318|UniProtKB=H2UI49	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00021	FGF signaling pathway	P00639	Shc	RAT|RGD=69348|UniProtKB=O70143	SHC-transforming protein 3	ISS	9507002	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	FUSNN|EnsemblGenome=FN0102|UniProtKB=Q8RH18	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00029	Huntington disease	P00807	Actin	ORYSJ|EnsemblGenome=OS05G0438800|UniProtKB=Q75HX0	Actin	IDA	14684598	PubMed	PTHR11937:SF248	SUBFAMILY NOT NAMED
P00059	p53 pathway	G01575	GADD45	PANTR|Ensembl=ENSPTRG00000000842|UniProtKB=H2R902	Growth arrest and DNA-damage-inducible, alpha	ISS	9827804	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P00055	Transcription regulation by bZIP transcription factor	P01389	TTF2	MOUSE|MGI=MGI=105044|UniProtKB=Q62187	Transcription termination factor 1	IGI			PTHR10641:SF939	TRANSCRIPTION TERMINATION FACTOR 1
P05728	Anandamide degradation	P05741	FAAH	MOUSE|MGI=MGI=109609|UniProtKB=O08914	Fatty-acid amide hydrolase 1	RCA			PTHR11895:SF91	FATTY-ACID AMIDE HYDROLASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00093	Tip60	HUMAN|HGNC=5275|UniProtKB=Q92993	Histone acetyltransferase KAT5	IDA	11441186	PubMed	PTHR10615:SF124	HISTONE ACETYLTRANSFERASE KAT5
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MOUSE|MGI=MGI=1915472|UniProtKB=P68372	Tubulin beta-4B chain	ISS	12932731	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00005	Angiogenesis	P00203	Erk	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00566	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00747	Rhodopsin	XENTR|Xenbase=XB-GENE-966887|UniProtKB=A4IGS9	Rhodopsin	ISS	1634520	PubMed	PTHR24240:SF15	RHODOPSIN
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	TAS	10995439	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00034	Integrin signalling pathway	P00932	FAK	CAEBR|Gene=CBG10801|UniProtKB=A8XBU1	Protein CBR-KIN-32	ISS			PTHR24418:SF367	FOCAL ADHESION KINASE, ISOFORM D
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00010	B cell activation	P00384	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IDA	15572354	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P04393	Ras Pathway	P04559	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	IDA	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	RCA	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	SCHPO|PomBase=SPAC6G9.11|UniProtKB=Q92356	Synaptobrevin homolog 1	ISS			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00012	Cadherin signaling pathway	P00475	Frizzled	XENTR|Xenbase=XB-GENE-487022|UniProtKB=F6SH04	Uncharacterized protein (Fragment)	ISS	11212302	PubMed	PTHR11309:SF34	FRIZZLED-2
P00053	T cell activation	P01307	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MACMU|Ensembl=ENSMMUG00000014597|UniProtKB=F6VAQ6	Glycogen synthase kinase-3 alpha	ISS	12086949	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00029	Huntington disease	P00811	Arp2/3 complex	HUMAN|HGNC=708|UniProtKB=O15511	Actin-related protein 2/3 complex subunit 5	TAS	9230079	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	RAT|RGD=1306665|UniProtKB=E9PTW9	Protein Tle2	ISS	9783586	PubMed	PTHR10814:SF4	AMINO-TERMINAL ENHANCER OF SPLIT-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	MONDO|Ensembl=ENSMODG00000015246|UniProtKB=F6UJF5	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00019	Endothelin signaling pathway	P00586	Gq	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04393	Ras Pathway	P04564	MAPKAP	MACMU|Ensembl=ENSMMUG00000023567|UniProtKB=F7HHY8	Uncharacterized protein	ISS	8262198	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00049	Parkinson disease	G01547	DAT	HUMAN|HGNC=11049|UniProtKB=Q01959	Sodium-dependent dopamine transporter	ISS	92107910	PubMed	PTHR11616:SF38	SODIUM-DEPENDENT DOPAMINE TRANSPORTER
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	NEUCR|EnsemblGenome=EFNCRG00000000159|UniProtKB=F5HH30	Guanine nucleotide-binding protein beta subunit	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00898	FKHR	RAT|RGD=1309196|UniProtKB=D3ZBQ1	Forkhead box O3a (Predicted)	ISS	12884295	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00049	Parkinson disease	P01242	Casein kinase I	HUMAN|HGNC=2456|UniProtKB=Q9Y6M4	Casein kinase I isoform gamma-3	IDA	10617630	PubMed	PTHR11909:SF151	CASEIN KINASE I ISOFORM GAMMA-3
P00036	Interleukin signaling pathway	P00981	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	CANLF|Ensembl=ENSCAFG00000011148|UniProtKB=J9P1Y8	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF170	REGULATOR OF G-PROTEIN SIGNALING 9
P05731	GABA-B receptor II signaling	P05754	Ggamma	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00018	EGF receptor signaling pathway	P00559	MEK1-2	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00384	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	ISS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00053	T cell activation	P01330	IKK	MACMU|Ensembl=ENSMMUG00000008351|UniProtKB=F7HRV5	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00010	B cell activation	P00402	Jnk	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00036	Interleukin signaling pathway	P00980	IRS1/2	CANLF|Ensembl=ENSCAFG00000010397|UniProtKB=E2RDB5	Uncharacterized protein	ISS	15110093	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00021	FGF signaling pathway	P00643	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00582	COX-2	PANTR|Ensembl=ENSPTRG00000001786|UniProtKB=H2Q0S9	Prostaglandin-endoperoxide synthase 2 (Prostaglandin G/H synthase and cyclooxygenase)	ISS	97393071	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00627	ERK1-2	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05931	EGR	MACMU|Ensembl=ENSMMUG00000018025|UniProtKB=F7FJJ0	Early growth response protein	ISS			PTHR44685:SF1	EARLY GROWTH RESPONSE PROTEIN 1
P00006	Apoptosis signaling pathway	P00310	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IDA	10747026	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	HUMAN|HGNC=7777|UniProtKB=Q12968	Nuclear factor of activated T-cells, cytoplasmic 3	ISS	9133421	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	MOUSE|MGI=MGI=1338944|UniProtKB=Q61271	Activin receptor type-1B	IDA			PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02747	Histidine biosynthesis	P02986	Phosphoribosyl ATP pyrophosphatase	AQUAE|EnsemblGenome=aq_1968|UniProtKB=O67780	Histidine biosynthesis bifunctional protein HisIE	ISS			PTHR42945:SF1	HISTIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN HISIE, CHLOROPLASTIC
P04393	Ras Pathway	P04546	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	IDA	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=2685369|UniProtKB=Q5F226	Protocadherin Fat 2	ISS	8120095	PubMed	PTHR24026:SF37	PROTOCADHERIN FAT 2
P00052	TGF-beta signaling pathway	P01275	P38	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	TAS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04393	Ras Pathway	P04547	Ras	DANRE|ZFIN=ZDB-GENE-040426-740|UniProtKB=Q7ZUL8	Uncharacterized protein	ISS	10825661	PubMed	PTHR24070:SF381	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05912	Dopamine receptor mediated signaling pathway	P05963	MAO	MACMU|Ensembl=ENSMMUG00000019492|UniProtKB=F7D3H3	Amine oxidase [flavin-containing]	ISS	8602220	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P00036	Interleukin signaling pathway	P00979	MAPKAPK2	ORNAN|Ensembl=ENSOANG00000007737|UniProtKB=F6PX17	Uncharacterized protein	ISS			PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00021	FGF signaling pathway	P00624	14-3-3	CAEBR|Gene=CBG06174|UniProtKB=A8X0R4	Protein CBR-PAR-5	ISS	22318813	PubMed	PTHR18860:SF21	14-3-3-LIKE PROTEIN 1
P05918	p38 MAPK pathway	P06026	MEKK4	MOUSE|MGI=MGI=1346875|UniProtKB=O08648	Mitogen-activated protein kinase kinase kinase 4	RCA	97236778	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	RCA	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P05915	Opioid proenkephalin pathway	P05994	G-protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	10704417	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00005	Angiogenesis	P00223	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00633	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	EMENI|EnsemblGenome=CADANIAG00001443|UniProtKB=P10653	Tubulin beta-1 chain	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00046	Oxidative stress response	P01129	JNK1/2	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	TAS	10851062	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02738	De novo purine biosynthesis	P02899	GMP synthase	YEAST|SGD=S000004830|UniProtKB=P38625	GMP synthase [glutamine-hydrolyzing]	ISS			PTHR11922:SF2	GMP SYNTHASE  GLUTAMINE-HYDROLYZING
P06959	CCKR signaling map	P07110	PLC_beta	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	RCA	9038886	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P02788	Xanthine and guanine salvage pathway	P03248	Deoxyguanosine phosphorylase	BACSU|EnsemblGenome=BSU23490|UniProtKB=P46354	Purine nucleoside phosphorylase 1	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MOUSE|MGI=MGI=1343142|UniProtKB=Q9WV32	Actin-related protein 2/3 complex subunit 1B	IDA	12932731	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00624	14-3-3	ASHGO|EnsemblGenome=AGOS_AGR107C|UniProtKB=Q74ZU1	AGR107Cp	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P05728	Anandamide degradation	P05741	FAAH	PANTR|Ensembl=ENSPTRG00000000693|UniProtKB=H2PYY9	Uncharacterized protein	ISS	12060782	PubMed	PTHR11895:SF91	FATTY-ACID AMIDE HYDROLASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	HUMAN|HGNC=143|UniProtKB=P68032	Actin, alpha cardiac muscle 1	IC	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	DANRE|ZFIN=ZDB-GENE-050417-59|UniProtKB=Q15KE4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00029	Huntington disease	P00780	Microtubule	MONDO|Ensembl=ENSMODG00000003363|UniProtKB=F7CB79	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00053	T cell activation	P01307	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05730	Endogenous cannabinoid signaling	P05751	Galpha	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00010	B cell activation	P00371	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	CHICK|Ensembl=ENSGALG00000009320|UniProtKB=Q4JIM4	Presenilin-1	IDA	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00639	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	8264585	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	MYCTU|EnsemblGenome=Rv2445c|UniProtKB=P9WJH7	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	YEAST|SGD=S000000028|UniProtKB=P31109	Synaptobrevin homolog 1	IC			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000002647|UniProtKB=F7DIB7	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	CRYNJ|EnsemblGenome=CND03830|UniProtKB=Q5KI86	Uncharacterized protein	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DANRE|ZFIN=ZDB-GENE-030131-55|UniProtKB=Q6XNL8	Actin	IC	11889126	PubMed	PTHR11937:SF263	ACTIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00274	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=98960|UniProtKB=P22727	Protein Wnt-6	TAS	11266476	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	DROME|FlyBase=FBgn0011286|UniProtKB=Q24498	Ryanodine receptor	ISS	93202018	PubMed	PTHR13715:SF79	RYANODINE RECEPTOR
P00059	p53 pathway	P04609	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	PUCGT|EnsemblGenome=PGTG_11337|UniProtKB=E3KLJ3	Calmodulin	ISS	9753452	PubMed	PTHR23050:SF245	AT16150P-RELATED
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	PANTR|Ensembl=ENSPTRG00000002711|UniProtKB=H2Q276	Glutamate dehydrogenase 1	ISS			PTHR11606:SF25	GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02778	Sulfate assimilation	P03164	Adenylylsulfate kinase	ARATH|TAIR=AT3G03900|UniProtKB=Q9SRW7	Adenylyl-sulfate kinase 3	ISS			PTHR11055:SF34	ADENYLYL-SULFATE KINASE 3
P05730	Endogenous cannabinoid signaling	P05743	CB1	BOVIN|Ensembl=ENSBTAG00000046006|UniProtKB=G5E6R9	Uncharacterized protein	ISS	2165569	PubMed	PTHR22750:SF47	CANNABINOID RECEPTOR 1
P00046	Oxidative stress response	P01129	JNK1/2	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00589	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00627	ERK1-2	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=97614|UniProtKB=Q8R3B1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	15611108	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	DROME|FlyBase=FBgn0024913|UniProtKB=O61643	Inhibin beta chain	ISS	9618266	PubMed	PTHR11848:SF133	INHIBIN BETA A CHAIN
P00048	PI3 kinase pathway	P01177	P110ACT	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	CAEBR|Gene=CBG12516|UniProtKB=A8XFY3	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF110	RIBOSOMAL PROTEIN S6 KINASE II, ISOFORM A
P00005	Angiogenesis	P00187	beta catenin	CHICK|Ensembl=ENSGALG00000011905|UniProtKB=F1NHT7	Uncharacterized protein	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00046	Oxidative stress response	P01125	Stat1	DANRE|ZFIN=ZDB-GENE-980526-499|UniProtKB=Q6P943	Signal transducer and activator of transcription	TAS	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00048	PI3 kinase pathway	P01179	PKB	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	TAS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02754	Methylcitrate cycle	P03031	2-Methylcitrate dehydratase	YEAST|SGD=S000006206|UniProtKB=Q12428	Probable 2-methylcitrate dehydratase	ISS			PTHR16943:SF19	2-METHYLCITRATE DEHYDRATASE-RELATED
P00005	Angiogenesis	P00184	Src	ANOGA|EnsemblGenome=AGAP006510|UniProtKB=Q7Q5D3	Tyrosine-protein kinase	ISS			PTHR24418:SF283	TYROSINE-PROTEIN KINASE SRC64B
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00035	Interferon-gamma signaling pathway	P00961	STAT1	HUMAN|HGNC=11362|UniProtKB=P42224	Signal transducer and activator of transcription 1-alpha/beta	TAS	10207096	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P02743	Formyltetrahydroformate biosynthesis	P02952	Methylene tetrahydrofolate dehydrogenase	SYNY3|EnsemblGenome=BAA10139|UniProtKB=Q55626	Bifunctional protein FolD	ISS			PTHR10025:SF46	BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, MITOCHONDRIAL
P00021	FGF signaling pathway	P00642	MEK1-2	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00059	p53 pathway	G01579	PTEN	TAKRU|Ensembl=ENSTRUG00000009851|UniProtKB=H2TJ90	Uncharacterized protein	IGI	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MACMU|Ensembl=ENSMMUG00000004886|UniProtKB=F7AGT9	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00018	EGF receptor signaling pathway	P00551	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00589	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00048	PI3 kinase pathway	P01192	p110	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	BOVIN|Ensembl=ENSBTAG00000008026|UniProtKB=P01175	Oxytocin-neurophysin 1	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00633	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IGI	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00057	Wnt signaling pathway	P01465	Ggamma	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00046	Oxidative stress response	P01138	MKK4	BOVIN|Ensembl=ENSBTAG00000012103|UniProtKB=A5PJP8	MAP2K4 protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00012	Cadherin signaling pathway	P00470	F-actin	PANTR|Ensembl=ENSPTRG00000002086|UniProtKB=H2Q1A9	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000009794|UniProtKB=F6Y049	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF11	PROTOCADHERIN-15
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00053	T cell activation	P01331	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IDA	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	CAEBR|Gene=CBG09806|UniProtKB=A8X9P2	Clathrin heavy chain	ISS	9388255	PubMed	PTHR10292:SF1	CLATHRIN HEAVY CHAIN
P00018	EGF receptor signaling pathway	P00539	14-3-3	BOVIN|Gene=YWHAB|UniProtKB=P68250	14-3-3 protein beta/alpha	IGI	1671102	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DANRE|ZFIN=ZDB-GENE-000329-3|UniProtKB=Q7ZVF9	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00056	VEGF signaling pathway	P01422	eNOS	MACMU|Ensembl=ENSMMUG00000020437|UniProtKB=F6WEB2	Nitric oxide synthase	ISS	10435050	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00005	Angiogenesis	P00199	JNKK1	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	HUMAN|HGNC=11772|UniProtKB=P36897	TGF-beta receptor type-1	TAS	10683140	PubMed	PTHR23255:SF61	TGF-BETA RECEPTOR TYPE-1
P00046	Oxidative stress response	P01134	cPLA2	PANTR|Ensembl=ENSPTRG00000001787|UniProtKB=H2Q0T0	Phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00021	FGF signaling pathway	P00623	FGF	RAT|RGD=2609|UniProtKB=P13109	Fibroblast growth factor 2	IGI	12788918	PubMed	PTHR11486:SF83	FIBROBLAST GROWTH FACTOR 2
P00012	Cadherin signaling pathway	P00474	Wnt	RAT|RGD=1597195|UniProtKB=D4A9J2	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00019	Endothelin signaling pathway	P00591	PLCbeta	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	RCA	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P05730	Endogenous cannabinoid signaling	P05751	Galpha	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	RCA	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00564	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00951	Jnk	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00019	Endothelin signaling pathway	P00590	IP3 R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	RAT|RGD=1309063|UniProtKB=Q1KQ07	Signal transducer and activator of transcription	ISS	12039028	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	MOUSE|MGI=MGI=95814|UniProtKB=Q60934	Glutamate receptor ionotropic, kainate 1	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P02738	De novo purine biosynthesis	P02898	Phosphoribosylformylglycinamide  synthase	THEMA|EnsemblGenome=TM_1246|UniProtKB=Q9X0X3	Phosphoribosylformylglycinamidine synthase subunit PurL	ISS			PTHR10099:SF1	PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	TAS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00009	Axon guidance mediated by netrin	P00366	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12874273	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00021	FGF signaling pathway	P00628	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00006	Apoptosis signaling pathway	P00302	ATF	MONDO|Ensembl=ENSMODG00000003042|UniProtKB=F6Q0D0	Uncharacterized protein	ISS	11390664	PubMed	PTHR23351:SF23	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-3
P00029	Huntington disease	P00790	beta-Tubulin	PANTR|Ensembl=ENSPTRG00000009878|UniProtKB=H2QEA0	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00021	FGF signaling pathway	P00641	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05913	Enkephalin release	P05972	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00012	Cadherin signaling pathway	P00466	EGFR	HUMAN|HGNC=3431|UniProtKB=P21860	Receptor tyrosine-protein kinase erbB-3	ISS	17432904	gi	PTHR24416:SF88	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3
P04398	p53 pathway feedback loops 2	P04661	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P05918	p38 MAPK pathway	P06031	p38alpha	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04393	Ras Pathway	P04552	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00018	EGF receptor signaling pathway	P00565	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IGI	15572354	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	9603989	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	11956331	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	HUMAN|HGNC=4383|UniProtKB=P30679	Guanine nucleotide-binding protein subunit alpha-15	IDA	11534853	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01336	Jnk	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	BOVIN|Ensembl=ENSBTAG00000003043|UniProtKB=P63212	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	SCHMA|EnsemblGenome=Smp_165490|UniProtKB=C1LZY9	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05913	Enkephalin release	P05977	G-Protein (s)	DANRE|ZFIN=ZDB-GENE-030131-7595|UniProtKB=Q6PBR4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00045	Notch signaling pathway	P01103	Next	MACMU|Ensembl=ENSMMUG00000018116|UniProtKB=F7FGM9	Delta-like protein	ISS	12826675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	TAKRU|Ensembl=ENSTRUG00000011358|UniProtKB=H2TVF7	Uncharacterized protein	ISS			PTHR18945:SF751	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00205	GAP	HUMAN|HGNC=9871|UniProtKB=P20936	Ras GTPase-activating protein 1	IDA	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00053	T cell activation	P01302	CD3 eta	CANLF|Ensembl=ENSCAFG00000012802|UniProtKB=P27597	T-cell surface glycoprotein CD3 epsilon chain	IGI	9886373	PubMed	PTHR10570:SF9	T-CELL SURFACE GLYCOPROTEIN CD3 EPSILON CHAIN
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01219	SAPK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00182	p38MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05912	Dopamine receptor mediated signaling pathway	P05960	VAT2	MACMU|Ensembl=ENSMMUG00000014817|UniProtKB=F6VXD8	Uncharacterized protein	ISS	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00036	Interleukin signaling pathway	P00990	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00054	Toll receptor signaling pathway	P01380	TLR1,2,6	MACMU|Gene=TLR2|UniProtKB=B3Y618	Toll-like receptor 2	ISS			PTHR24365:SF17	TOLL-LIKE RECEPTOR 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	RAT|RGD=621516|UniProtKB=G3V6P8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00019	Endothelin signaling pathway	P00586	Gq	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00384	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00036	Interleukin signaling pathway	P00965	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00057	Wnt signaling pathway	P01453	Ebi	CANLF|Ensembl=ENSCAFG00000011362|UniProtKB=F1Q0G6	Uncharacterized protein	ISS	11389839	PubMed	PTHR22846:SF2	F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN TBL1X
P00006	Apoptosis signaling pathway	P00322	Cytochrome C	EMENI|EnsemblGenome=CADANIAG00006747|UniProtKB=P38091	Cytochrome c	ISS			PTHR11961:SF12	CYTOCHROME C
P00004	Alzheimer disease-presenilin pathway	P00137	Tip60	RAT|RGD=727966|UniProtKB=Q810T5	Histone acetyltransferase KAT7	ISS			PTHR10615:SF102	HISTONE ACETYLTRANSFERASE KAT7
P00036	Interleukin signaling pathway	P00966	mTOR	BOVIN|Ensembl=ENSBTAG00000015325|UniProtKB=E1BFB4	Uncharacterized protein	ISS	8662507	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	BRAFL|Gene=BRAFLDRAFT_60743|UniProtKB=C3XYD4	Putative uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00629	PP2A	XENTR|Xenbase=XB-GENE-971147|UniProtKB=F7AB62	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B	ISS	137056	PubMed	PTHR11871:SF2	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B ALPHA ISOFORM
P00005	Angiogenesis	P00219	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00965	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	IC	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00048	PI3 kinase pathway	P01194	S6K	MOUSE|MGI=MGI=1270849|UniProtKB=Q8BSK8	Ribosomal protein S6 kinase beta-1	IDA	15116068	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P05731	GABA-B receptor II signaling	P05754	Ggamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00016	Cytoskeletal regulation by Rho GTPase	P00514	MLCK	CHICK|Gene=Mylk|UniProtKB=P11799	Myosin light chain kinase, smooth muscle	TAS	11157482	PubMed	PTHR45480:SF1	MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CANLF|Ensembl=ENSCAFG00000005662|UniProtKB=E2R907	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01023	CaMKII	CAEEL|WormBase=WBGene00006779|UniProtKB=O62305	Calcium/calmodulin-dependent protein kinase type II	ISS	12888804	PubMed	PTHR43940:SF1	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN
P04393	Ras Pathway	P04566	Stat 1/3	CANLF|Ensembl=ENSCAFG00000015213|UniProtKB=E2RB82	Signal transducer and activator of transcription	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00020	FAS signaling pathway	P00606	Caspase10	HUMAN|HGNC=1500|UniProtKB=Q92851	Caspase-10	IGI	11717445	PubMed	PTHR10454:SF26	CASPASE-10
P00021	FGF signaling pathway	P00623	FGF	ORNAN|Ensembl=ENSOANG00000014242|UniProtKB=F6WG78	Fibroblast growth factor	ISS	12057924	PubMed	PTHR11486:SF86	FIBROBLAST GROWTH FACTOR 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00912	Arp2/3	DANRE|ZFIN=ZDB-GENE-040116-1|UniProtKB=Q7ZUQ0	Actin related protein 2/3 complex, subunit 1A	ISS	12963527	gi	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00037	Ionotropic glutamate receptor pathway	P01018	Glu1	CAEBR|Gene=CBG18112|UniProtKB=A8XT20	Protein CBR-GLR-1	ISS	8804111	PubMed	PTHR18966:SF297	GLUTAMATE RECEPTOR 1
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	PANTR|Ensembl=ENSPTRG00000014976|UniProtKB=H2R892	Uncharacterized protein	ISS	20012997	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00046	Oxidative stress response	P01138	MKK4	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	18021322	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	TAS	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P02775	Salvage pyrimidine ribonucleotides	P03155	Cytosine deaminase	BACSU|EnsemblGenome=BSU13170|UniProtKB=O34598	Guanine deaminase	ISS			PTHR44192:SF2	SUBFAMILY NOT NAMED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000020399|UniProtKB=F6U813	Adenosine receptor A2	ISS			PTHR24246:SF18	ADENOSINE RECEPTOR A2B
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	CHICK|Ensembl=ENSGALG00000004693|UniProtKB=Q5ZJI7	Uncharacterized protein	ISS	12473693	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00018	EGF receptor signaling pathway	P00564	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00029	Huntington disease	P00786	ARF	CANLF|Ensembl=ENSCAFG00000029086|UniProtKB=J9P5N6	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF110	ADP-RIBOSYLATION FACTOR 4
P00048	PI3 kinase pathway	P01179	PKB	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	TAS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	DROME|FlyBase=FBgn0000319|UniProtKB=P29742	Clathrin heavy chain	IDA	9388255	PubMed	PTHR10292:SF1	CLATHRIN HEAVY CHAIN
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MACMU|Ensembl=ENSMMUG00000019112|UniProtKB=F6T8S6	N-methyl D-aspartate receptor subtype 2B	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00029	Huntington disease	P00794	Hippi	CANLF|Ensembl=ENSCAFG00000009895|UniProtKB=F1P6B8	Uncharacterized protein	ISS	11788820	PubMed	PTHR16011:SF0	INTRAFLAGELLAR TRANSPORT PROTEIN 57 HOMOLOG
P00052	TGF-beta signaling pathway	P01284	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MACMU|Ensembl=ENSMMUG00000014227|UniProtKB=P56490	Muscarinic acetylcholine receptor M5	IDA	12181435	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Gene=GRIK4|UniProtKB=Q5IS46	Glutamate receptor ionotropic, kainate 4	ISS	11319238	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00009	Axon guidance mediated by netrin	P00363	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00223	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01335	jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00018	EGF receptor signaling pathway	P00551	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	IGI	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00049	Parkinson disease	P01227	20S proteasome	CAEBR|Gene=CBG09365|UniProtKB=A8X995	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF12	PROTEASOME SUBUNIT ALPHA TYPE-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	SCLS1|EnsemblGenome=SS1G_03482|UniProtKB=A7EDU2	Guanine nucleotide-binding protein beta subunit	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P02747	Histidine biosynthesis	P02984	Imidazol glycerol phosphate dehydratase	YEAST|SGD=S000005728|UniProtKB=P06633	Imidazoleglycerol-phosphate dehydratase	ISS			PTHR23133:SF2	IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	HUMAN|HGNC=1401|UniProtKB=Q02641	Voltage-dependent L-type calcium channel subunit beta-1	IC	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00029	Huntington disease	P00810	GAPDH	CAEBR|Gene=CBG01479|UniProtKB=A8WQL1	Glyceraldehyde-3-phosphate dehydrogenase	ISS			PTHR10836:SF65	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE 1-RELATED
P00053	T cell activation	P01333	cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	TAS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	10693759	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_58093|UniProtKB=C3Z4K3	Putative uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00018	EGF receptor signaling pathway	P00545	JNK1-3	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IGI	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00547	PP2A	ORNAN|Ensembl=ENSOANG00000009097|UniProtKB=F7G755	Uncharacterized protein	ISS	11007767	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00049	Parkinson disease	P01236	Casein kinase II	SCHPO|PomBase=SPBC2G5.02c|UniProtKB=O94281	Probable casein kinase II subunit beta-2	IDA	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P04398	p53 pathway feedback loops 2	P04657	P110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00547	PP2A	RAT|RGD=6503746|UniProtKB=Q80W83	Protein LOC100909468	ISS	96161994	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IDA	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00006	Apoptosis signaling pathway	P00269	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CAEBR|Gene=CBG18112|UniProtKB=A8XT20	Protein CBR-GLR-1	ISS	12941441	PubMed	PTHR18966:SF297	GLUTAMATE RECEPTOR 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CAEEL|WormBase=WBGene00001648|UniProtKB=P51875	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00023	General transcription regulation	P00658	TBP-associated factors	BOVIN|Ensembl=ENSBTAG00000016887|UniProtKB=Q3ZBP7	TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa	ISS			PTHR13218:SF8	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02781	Threonine biosynthesis	P03190	Threonine synthase	MOUSE|MGI=MGI=3041254|UniProtKB=Q80W22	Threonine synthase-like 2	ISS			PTHR42690:SF1	THREONINE SYNTHASE-LIKE 2
P00010	B cell activation	P00384	p38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	IDA	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00243	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	10395542	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04393	Ras Pathway	P04552	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00004	Alzheimer disease-presenilin pathway	P00125	Ire-1 C-terminal fragment	YEAST|SGD=S000001121|UniProtKB=P32361	Serine/threonine-protein kinase/endoribonuclease IRE1	IDA	10619423	PubMed	PTHR13954:SF6	INOSITOL-REQUIRING ENZYME-1
P00029	Huntington disease	P00782	alpha-Adaptin	SCHPO|PomBase=SPBC691.03c|UniProtKB=Q9C0W7	AP-2 complex subunit alpha	IDA	11532990	PubMed	PTHR22780:SF4	AP-2 COMPLEX SUBUNIT ALPHA-2
P00048	PI3 kinase pathway	P01182	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00010	B cell activation	P00383	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00029	Huntington disease	P00774	Dynein complex	RAT|RGD=621130|UniProtKB=Q62698	Cytoplasmic dynein 1 light intermediate chain 2	IPI	9454836	PubMed	PTHR12688:SF1	CYTOPLASMIC DYNEIN 1 LIGHT INTERMEDIATE CHAIN 2
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00023	General transcription regulation	P00663	TFIIFalpha	PANTR|Ensembl=ENSPTRG00000010362|UniProtKB=H2QF47	General transcription factor IIF, polypeptide 1, 74kDa	ISS	12732728	PubMed	PTHR13011:SF0	GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=97614|UniProtKB=Q8R3B1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	7822322	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00307	ELF2alpha	RAT|RGD=620963|UniProtKB=P68101	Eukaryotic translation initiation factor 2 subunit 1	ISS	10889505	PubMed	PTHR10602:SF0	EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1
P00018	EGF receptor signaling pathway	P00557	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DANRE|ZFIN=ZDB-GENE-040426-1489|UniProtKB=Q6PHV0	Syntaxin 3A	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05731	GABA-B receptor II signaling	P05760	AC	MONDO|Ensembl=ENSMODG00000001430|UniProtKB=F7BCI5	Uncharacterized protein	ISS	8163524	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00018	EGF receptor signaling pathway	P00550	Grb2	DROME|FlyBase=FBgn0004638|UniProtKB=Q08012	Protein enhancer of sevenless 2B	ISS	51702266	gi	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	IDA	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	CAEEL|WormBase=WBGene00019212|UniProtKB=O44836	Zinc MetalloProtease	TAS	12834808	PubMed	PTHR10201:SF168	ZINC METALLOPROTEASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IDA	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	IDA	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	IDA	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00975	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	8262392	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00049	Parkinson disease	P01219	SAPK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00006	Apoptosis signaling pathway	P00321	HSP70	NEUCR|EnsemblGenome=EFNCRG00000003675|UniProtKB=P78695	78 kDa glucose-regulated protein homolog	ISS	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00021	FGF signaling pathway	P00623	FGF	BOVIN|Ensembl=ENSBTAG00000012413|UniProtKB=F1MFC0	Fibroblast growth factor	ISS	11376006	PubMed	PTHR11486:SF17	FIBROBLAST GROWTH FACTOR 12
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	RAT|RGD=1305848|UniProtKB=P85970	Actin-related protein 2/3 complex subunit 2	ISS	17943202	gi	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00059	p53 pathway	P04633	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05918	p38 MAPK pathway	P06021	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	15470041	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=1309878|UniProtKB=D4ACX8	Protocadherin-16	ISS	8120095	PubMed	PTHR43956:SF6	PROTOCADHERIN-16
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00006	Apoptosis signaling pathway	P00310	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	IDA	14505573	PubMed	PTHR10048:SF14	PI-3 KINASE
P00047	PDGF signaling pathway	P01161	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00057	Wnt signaling pathway	P01443	Phospholipase C	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00015	Circadian clock system	G01501	cry	CHICK|Gene=CRY2|UniProtKB=Q8QG60	Cryptochrome-2	ISS			PTHR11455:SF15	CRYPTOCHROME-2
P00021	FGF signaling pathway	P00627	ERK1-2	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00256	PLC-gamma	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	HUMAN|HGNC=10434|UniProtKB=O75582	Ribosomal protein S6 kinase alpha-5	ISS	6755374	gi	PTHR24351:SF115	RIBOSOMAL PROTEIN S6 KINASE ALPHA-5
P00053	T cell activation	P01316	MHC-antigen	MOUSE|MGI=MGI=95924|UniProtKB=Q9QWV1	H2-O alpha	IPI	73139	PubMed	PTHR19944:SF44	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DO ALPHA CHAIN
P05913	Enkephalin release	P05972	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00034	Integrin signalling pathway	P00928	alpha actinin	TAKRU|Ensembl=ENSTRUG00000011100|UniProtKB=H2TTL6	Uncharacterized protein (Fragment)	ISS	2116421	PubMed	PTHR43947:SF3	ALPHA-ACTININ-1
P05913	Enkephalin release	P05977	G-Protein (s)	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00006	Apoptosis signaling pathway	P00274	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00020	FAS signaling pathway	P00615	JNK	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	11956331	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00019	Endothelin signaling pathway	P00591	PLCbeta	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00049	Parkinson disease	P01242	Casein kinase I	ARATH|TAIR=AT5G43320|UniProtKB=Q9LSX4	Casein kinase 1-like protein 8	IDA	11437445	PubMed	PTHR11909:SF178	CASEIN KINASE 1-LIKE PROTEIN 8
P00048	PI3 kinase pathway	P01199	Galpha	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04396	Vitamin D metabolism and pathway	P04602	RXR	BOVIN|Ensembl=ENSBTAG00000012500|UniProtKB=F1MWQ3	Uncharacterized protein	ISS			PTHR24082:SF115	RETINOIC ACID RECEPTOR ALPHA
P02781	Threonine biosynthesis	P03190	Threonine synthase	YEAST|SGD=S000000649|UniProtKB=P16120	Threonine synthase	ISS	11756443	PubMed	PTHR42690:SF1	THREONINE SYNTHASE-LIKE 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	TAS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00059	p53 pathway	P04612	HDAC1	HUMAN|HGNC=4852|UniProtKB=Q13547	Histone deacetylase 1	IDA	10485845	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	RCA	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00057	Wnt signaling pathway	P01431	LRP5/6	ANOGA|EnsemblGenome=AGAP011770|UniProtKB=Q7PV65	AGAP011770-PA (Fragment)	ISS	11029006	PubMed	PTHR44017:SF2	ARROW
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	DANRE|ZFIN=ZDB-GENE-980526-526|UniProtKB=P24257	Protein Wnt-1	TAS	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00004	Alzheimer disease-presenilin pathway	P00126	Fe65	PANTR|Ensembl=ENSPTRG00000003288|UniProtKB=H2Q320	Uncharacterized protein	ISS	11441186	PubMed	PTHR14058:SF5	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1
P00029	Huntington disease	P00786	ARF	MACMU|Ensembl=ENSMMUG00000002792|UniProtKB=F7H235	ADP-ribosylation factor 1	ISS	11752622	PubMed	PTHR11711:SF294	ADP-RIBOSYLATION FACTOR 3
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	HUMAN|HGNC=20289|UniProtKB=Q8N752	Casein kinase I isoform alpha-like	ISS	10617630	PubMed	PTHR11909:SF139	CASEIN KINASE I ISOFORM ALPHA-LIKE
P00059	p53 pathway	G04694	p110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00012	Cadherin signaling pathway	P00474	Wnt	RAT|RGD=1307015|UniProtKB=D3ZRW5	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00030	Hypoxia response via HIF activation	P00824	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00057	Wnt signaling pathway	P01434	sFRP	HUMAN|HGNC=10776|UniProtKB=Q8N474	Secreted frizzled-related protein 1	ISS	9096311	PubMed	PTHR11309:SF87	SECRETED FRIZZLED-RELATED PROTEIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IC	2837282	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DROME|FlyBase=FBgn0003093|UniProtKB=P13678	Protein kinase C	IC	2837282	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00566	ERK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01435	SWI/SNF	CHLTR|EnsemblGenome=CT_555|UniProtKB=O84559	SWI/SNF family helicase	IDA	11532957	PubMed	PTHR10799:SF810	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	RAT|RGD=2958|UniProtKB=P63251	G protein-activated inward rectifier potassium channel 1	ISS	12374786	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	CHICK|Gene=CHRNA1|UniProtKB=P09479	Acetylcholine receptor subunit alpha	ISS	85270494	PubMed	PTHR18945:SF74	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MOUSE|MGI=MGI=107717|UniProtKB=Q8VDD5	Myosin-9	ISS	89264452	PubMed	PTHR13140:SF317	MYOSIN-9
P02728	Arginine biosynthesis	P02841	argininosuccinate lyase	AQUAE|EnsemblGenome=aq_1372|UniProtKB=O67383	Argininosuccinate lyase	ISS			PTHR43814:SF1	ARGININOSUCCINATE LYASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	IC	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00057	Wnt signaling pathway	P01432	Beta-Catenin	XENTR|Xenbase=XB-GENE-487200|UniProtKB=Q28GC2	Catenin (Cadherin associated protein), beta 1, 88kDa	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P05916	Opioid prodynorphin pathway	P05999	provasopressin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CANLF|Gene=GRIN1|UniProtKB=Q5R1P0	Glutamate receptor ionotropic, NMDA 1	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01182	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MACMU|Ensembl=ENSMMUG00000010987|UniProtKB=F7GCX9	Uncharacterized protein	ISS	12497607	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MONDO|Ensembl=ENSMODG00000015246|UniProtKB=F6UJF5	Uncharacterized protein	ISS	11431030	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00056	VEGF signaling pathway	P01417	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00057	Wnt signaling pathway	P01458	Protein Kinase C	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	IC	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MACMU|Ensembl=ENSMMUG00000019112|UniProtKB=F6T8S6	N-methyl D-aspartate receptor subtype 2B	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00018	EGF receptor signaling pathway	P00543	ERK1-2	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00254	GTPase	XENTR|Xenbase=XB-GENE-941426|UniProtKB=Q28HZ4	Novel Rho protein	ISS	15668138	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00748	Gbeta5L	HUMAN|HGNC=4401|UniProtKB=O14775	Guanine nucleotide-binding protein subunit beta-5	IEA	9754712	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P05913	Enkephalin release	P05974	G-Protein (i)	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00010	B cell activation	P00376	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P02757	O-antigen biosynthesis	P03046	dTDP-glucose pyrophosphorylase	BACSU|EnsemblGenome=BSU37840|UniProtKB=P39629	Glucose-1-phosphate thymidylyltransferase	ISS			PTHR43532:SF3	GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE 2
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95808|UniProtKB=P23818	Glutamate receptor 1	ISS	12941441	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00018	EGF receptor signaling pathway	P00562	p38	DANRE|ZFIN=ZDB-GENE-990415-257|UniProtKB=O42376	Mitogen-activated protein kinase 12	ISS	10514528	PubMed	PTHR24055:SF339	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00047	PDGF signaling pathway	P01165	SRF	MONDO|Ensembl=ENSMODG00000018981|UniProtKB=F7FP88	Uncharacterized protein	ISS	15326221	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_56687|UniProtKB=C3YC50	Putative uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000023202|UniProtKB=F7EU36	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P06217	Toll pathway-drosophila	P06337	TL	DROME|FlyBase=FBgn0262473|UniProtKB=P08953	Protein toll	IDA	12872120	PubMed	PTHR45263:SF1	PROTEIN TOLL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00865	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	7680960	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00047	PDGF signaling pathway	P01148	Grb2	MOUSE|MGI=MGI=108088|UniProtKB=Q9QYY0	GRB2-associated-binding protein 1	ISS			PTHR12156:SF18	GRB2-ASSOCIATED-BINDING PROTEIN 1
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CAEBR|Gene=CBG05858|UniProtKB=A8X1H0	Protein CBR-EGL-19 (Fragment)	ISS	8838325	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	TAS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04393	Ras Pathway	P04553	PAK	MOUSE|MGI=MGI=1339656|UniProtKB=Q61036	Serine/threonine-protein kinase PAK 3	IDA	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	8837781	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00046	Oxidative stress response	P01131	MKP5	MOUSE|MGI=MGI=1917936|UniProtKB=Q6PCP3	Dual specificity phosphatase 16	ISS			PTHR10159:SF37	DUAL SPECIFICITY PROTEIN PHOSPHATASE 16
P02755	Methylmalonyl pathway	P03034	Methylmalonyl-CoA mutase	RAT|RGD=1587662|UniProtKB=D3ZKG1	Protein Mut	ISS			PTHR42710:SF1	METHYLMALONYL-COA MUTASE, MITOCHONDRIAL
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000004474|UniProtKB=E2RCN6	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00059	p53 pathway	P04630	PP2A	DANRE|ZFIN=ZDB-GENE-040426-2487|UniProtKB=Q803G3	Serine/threonine-protein phosphatase	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Ensembl=ENSBTAG00000047719|UniProtKB=Q95136	D(1A) dopamine receptor	IDA			PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00049	Parkinson disease	P01227	20S proteasome	MACMU|Ensembl=ENSMMUG00000010740|UniProtKB=F7G176	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF13	PROTEASOME SUBUNIT ALPHA TYPE-4
P00006	Apoptosis signaling pathway	P00318	PKCs	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IDA	3045562	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	MYCTU|EnsemblGenome=Rv2445c|UniProtKB=P9WJH7	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00057	Wnt signaling pathway	P01444	Wnt	MONDO|Ensembl=ENSMODG00000013820|UniProtKB=F6SF10	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P00018	EGF receptor signaling pathway	P00547	PP2A	CANLF|Ensembl=ENSCAFG00000006453|UniProtKB=F6X958	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	MOUSE|MGI=MGI=109284|UniProtKB=Q61144	Presenilin-2	IDA	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00010	B cell activation	P00385	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P06587	Nicotine pharmacodynamics pathway	P06605	KCNK3/9	PANTR|Ensembl=ENSPTRG00000020614|UniProtKB=H2QWR7	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00019	Endothelin signaling pathway	P00589	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	IGI	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05730	Endogenous cannabinoid signaling	P05746	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00006	Apoptosis signaling pathway	P00297	NFkappaB	MOUSE|MGI=MGI=1099800|UniProtKB=Q9WTK5	Nuclear factor NF-kappa-B p100 subunit	IDA	20151924	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00057	Wnt signaling pathway	P01468	APC	XENTR|Xenbase=XB-GENE-480855|UniProtKB=F6XK08	Uncharacterized protein (Fragment)	ISS	8259518	PubMed	PTHR12607:SF11	ADENOMATOUS POLYPOSIS COLI PROTEIN
P00012	Cadherin signaling pathway	P00463	betacatenin	TAKRU|Ensembl=ENSTRUG00000003520|UniProtKB=H2S791	Uncharacterized protein	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P00005	Angiogenesis	P00187	beta catenin	MACMU|Ensembl=ENSMMUG00000014627|UniProtKB=F7GNE4	Catenin beta-1	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00012	Cadherin signaling pathway	P00471	Cadherin	ORNAN|Ensembl=ENSOANG00000002504|UniProtKB=F6VET9	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF290	CADHERIN-10
P00034	Integrin signalling pathway	P00944	Actin	MOUSE|MGI=MGI=2444552|UniProtKB=Q8BFZ3	Beta-actin-like protein 2	ISS	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00010	B cell activation	P00375	Calmodulin	MONDO|Ensembl=ENSMODG00000023174|UniProtKB=F7D7P2	Uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF197	CALMODULIN-LIKE PROTEIN 3
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00029	Huntington disease	P00796	Kainate receptor	BOVIN|Ensembl=ENSBTAG00000033153|UniProtKB=F1MG21	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00539	14-3-3	MONDO|Ensembl=ENSMODG00000015951|UniProtKB=F7FRT9	Uncharacterized protein	ISS	12861023	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04665	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	PANTR|Ensembl=ENSPTRG00000009477|UniProtKB=H2QDK7	Ribosomal protein S6 kinase	ISS	15116068	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IDA	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00036	Interleukin signaling pathway	P00983	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01413	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P02771	Pyrimidine Metabolism	P03131	5'-Nucleotidase	PANTR|Ensembl=ENSPTRG00000018391|UniProtKB=H2QTC9	5'-nucleotidase, ecto (CD73)	RCA	3219501	gi	PTHR11575:SF25	5'-NUCLEOTIDASE
P00056	VEGF signaling pathway	P01411	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00019	Endothelin signaling pathway	P00566	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00577	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ARATH|TAIR=AT4G19006|UniProtKB=Q8GYA6	26S proteasome non-ATPase regulatory subunit 13 homolog B	ISS			PTHR10539:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13
P00003	Alzheimer disease-amyloid secretase pathway	P00101	BACE-1	MACMU|Ensembl=ENSMMUG00000007785|UniProtKB=F7CQI1	Beta-secretase 1 isoform A preproprotein	ISS	10531052	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	DAPPU|EnsemblGenome=DAPPUDRAFT_301140|UniProtKB=E9HGM4	Putative uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	IDA	10995439	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00054	Toll receptor signaling pathway	G01550	Gene trancription	MACMU|Ensembl=ENSMMUG00000016857|UniProtKB=F7BWZ9	Uncharacterized protein	ISS	12871860	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	IDA	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IDA	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02736	Coenzyme A biosynthesis	P02883	Pantothenoylcysteine decarboxylase	METAC|EnsemblGenome=MA_1280|UniProtKB=Q8TRA0	Pantothenate metabolism flavoprotein	ISS			PTHR14359:SF6	PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	ANOGA|EnsemblGenome=AGAP009944|UniProtKB=Q7Q165	AGAP009944-PA	IC			PTHR11699:SF264	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	EMENI|EnsemblGenome=CADANIAG00002670|UniProtKB=Q5BH99	G-protein beta subunit [Source:UniProtKB/TrEMBLAcc:O74214]	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00015	Circadian clock system	P00506	BMAL1	CANLF|Ensembl=ENSCAFG00000008095|UniProtKB=J9NTT7	Uncharacterized protein	ISS	11163178	PubMed	PTHR23042:SF52	ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 1
P02736	Coenzyme A biosynthesis	P02884	Dephospho-CoA kinase	FUSNN|EnsemblGenome=FN1932|UniProtKB=Q8RHR7	Dephospho-CoA kinase	ISS			PTHR10695:SF26	BIFUNCTIONAL COENZYME A SYNTHASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DANRE|ZFIN=ZDB-GENE-030131-6503|UniProtKB=Q7ZUC5	Protein kinase C delta type	ISS	11880265	PubMed	PTHR24356:SF297	PROTEIN KINASE C DELTA TYPE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BOVIN|Ensembl=ENSBTAG00000001668|UniProtKB=F1N6L8	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00047	PDGF signaling pathway	P01152	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	8262392	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P05913	Enkephalin release	P05975	GPCR (s)	HUMAN|HGNC=8156|UniProtKB=P35372	Mu-type opioid receptor	ISS	11259498	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P04398	p53 pathway feedback loops 2	P04649	Myc	BOVIN|Ensembl=ENSBTAG00000008409|UniProtKB=Q2HJ27	Myc proto-oncogene protein	ISS	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	PANTR|Ensembl=ENSPTRG00000000313|UniProtKB=H2PY99	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00019	Endothelin signaling pathway	P00573	signal peptidase	YEAST|SGD=S000001461|UniProtKB=P15367	Signal peptidase complex catalytic subunit SEC11	ISS	2092035	PubMed	PTHR10806:SF6	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11
P04398	p53 pathway feedback loops 2	P04658	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	DROME|FlyBase=FBgn0011703|UniProtKB=P48591	Ribonucleoside-diphosphate reductase large subunit	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00034	Integrin signalling pathway	P00925	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00632	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01242	Casein kinase I	HUMAN|HGNC=2452|UniProtKB=P48730	Casein kinase I isoform delta	IDA	10617630	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CAEBR|Gene=CBG14578|UniProtKB=A8XK84	Protein CBR-LFI-1	ISS			PTHR23159:SF22	LIN-5  FIVE  INTERACTING PROTEIN
P02729	Ascorbate degradation	P02849	L-xylulose kinase	THEMA|EnsemblGenome=TM_0284|UniProtKB=Q9WYC0	Alternative Ribulokinase	ISS			PTHR43095:SF5	SUBFAMILY NOT NAMED
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01189	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	TAS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CIOIN|Ensembl=ENSCING00000000848|UniProtKB=F6SCP4	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Ensembl=ENSCAFG00000013755|UniProtKB=Q49LX5	Somatostatin receptor type 1	ISS	12181435	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P00005	Angiogenesis	P00192	PAR	MOUSE|MGI=MGI=101802|UniProtKB=P30558	Proteinase-activated receptor 1	RCA			PTHR24232:SF20	PROTEINASE-ACTIVATED RECEPTOR 1
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	MOUSE|MGI=MGI=97364|UniProtKB=O35516	Neurogenic locus notch homolog protein 2	IDA	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00014	Cholesterol biosynthesis	P00497	Anosterol synthase	YEAST|SGD=S000001114|UniProtKB=P38604	Lanosterol synthase	ISS	P38604	SPACC	PTHR11764:SF20	LANOSTEROL SYNTHASE
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1203729|UniProtKB=Q61194	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00053	T cell activation	P01300	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MACMU|Ensembl=ENSMMUG00000010046|UniProtKB=F6TFK0	Uncharacterized protein	ISS	10934230	PubMed	PTHR24230:SF8	LEUKOTRIENE B4 RECEPTOR 2
P00052	TGF-beta signaling pathway	P01284	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00030	Hypoxia response via HIF activation	P00825	Thioredoxin	DEIRA|EnsemblGenome=DR_A0164|UniProtKB=Q9RYY9	Thiol reductase thioredoxin	ISS			PTHR10438:SF357	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00648	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00006	Apoptosis signaling pathway	P00276	TRAIL-R	HUMAN|HGNC=11904|UniProtKB=O00220	Tumor necrosis factor receptor superfamily member 10A	IDA	10594023	PubMed	PTHR23097:SF179	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10A
P00034	Integrin signalling pathway	P00919	Arf6	TAKRU|Ensembl=ENSTRUG00000011714|UniProtKB=H2TY29	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P04393	Ras Pathway	P04552	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P06664	Gonadotropin-releasing hormone receptor pathway	P06743	Cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	RCA	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	MOUSE|MGI=MGI=1349763|UniProtKB=O08553	Dihydropyrimidinase-related protein 2	TAS	Q90635	SPACC	PTHR11647:SF56	DIHYDROPYRIMIDINASE-RELATED PROTEIN 2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	ISS			PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	MOUSE|MGI=MGI=1201678|UniProtKB=Q5SUF7	Protein Cacna1g	ISS	14526084	PubMed	PTHR10037:SF137	VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1G
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	RAT|RGD=1309504|UniProtKB=D3ZRN3	Protein Actbl2	ISS	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00056	VEGF signaling pathway	P01409	cPLA2	MONDO|Ensembl=ENSMODG00000011791|UniProtKB=F7CBU9	Phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00021	FGF signaling pathway	P00629	PP2A	BOVIN|Ensembl=ENSBTAG00000019784|UniProtKB=A4FV68	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	ISS	8703017	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00030	Hypoxia response via HIF activation	P00819	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00053	T cell activation	P01332	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02738	De novo purine biosynthesis	P02907	dADP kinase	EMENI|EnsemblGenome=CADANIAG00004263|UniProtKB=Q8TFN0	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MOUSE|MGI=MGI=1341110|UniProtKB=P97490	Adenylate cyclase type 8	ISS	8163524	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P02723	Adenine and hypoxanthine salvage pathway	P02812	Deoxyinosine phosphorylase	THEMA|EnsemblGenome=TM_1596|UniProtKB=Q9X1T2	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P06664	Gonadotropin-releasing hormone receptor pathway	G06891	Junc	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	RCA	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00029	Huntington disease	P00811	Arp2/3 complex	DICDI|dictyBase=DDB_G0277825|UniProtKB=O96622	Actin-related protein 2/3 complex subunit 1	TAS	12932731	PubMed	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P06587	Nicotine pharmacodynamics pathway	P06596	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	4504111	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00029	Huntington disease	P00796	Kainate receptor	MOUSE|MGI=MGI=95817|UniProtKB=Q8BMF5	Glutamate receptor ionotropic, kainate 4	ISS	12941441	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00006	Apoptosis signaling pathway	P00318	PKCs	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00752	cGMP-gated ion channel	PANTR|Ensembl=ENSPTRG00000020398|UniProtKB=H2QWE1	Uncharacterized protein	ISS	12432397	PubMed	PTHR10217:SF385	CYCLIC NUCLEOTIDE-GATED CATION CHANNEL BETA-3
P00034	Integrin signalling pathway	P00925	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00024	Glycolysis	P00680	Phosphoglyceromutase	MOUSE|MGI=MGI=97552|UniProtKB=Q9DBJ1	Phosphoglycerate mutase 1	RCA			PTHR11931:SF15	PHOSPHOGLYCERATE MUTASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04393	Ras Pathway	P04558	p38	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00045	Notch signaling pathway	P01103	Next	PANTR|Ensembl=ENSPTRG00000013250|UniProtKB=H2QJZ0	Delta-like protein	ISS	12826675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DROME|FlyBase=FBgn0000044|UniProtKB=P53501	Actin-57B	IC	11889126	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00004	Alzheimer disease-presenilin pathway	P00139	E-cadherin transmembrane fragment	RAT|RGD=69279|UniProtKB=Q9R0T4	Cadherin-1	IDA	12834808	PubMed	PTHR24027:SF319	CADHERIN-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	HUMAN|HGNC=1958|UniProtKB=P43681	Neuronal acetylcholine receptor subunit alpha-4	IC	17597586	PubMed	PTHR18945:SF401	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05925	beta-ARR1	DANRE|ZFIN=ZDB-GENE-060824-1|UniProtKB=C3PTE8	Beta-arrestin 1	ISS	4757780	gi	PTHR11792:SF22	BETA-ARRESTIN-1
P00057	Wnt signaling pathway	P01446	Calcineurin	MACMU|Ensembl=ENSMMUG00000004599|UniProtKB=F6Q932	Serine/threonine-protein phosphatase	ISS	12091710	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00052	TGF-beta signaling pathway	P01275	P38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	TAS	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00046	Oxidative stress response	P01134	cPLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	TAS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00048	PI3 kinase pathway	P01192	p110	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00005	Angiogenesis	P00189	Fzd	DANRE|ZFIN=ZDB-GENE-990415-224|UniProtKB=F1QBI2	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF34	FRIZZLED-2
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01143	ERK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00036	Interleukin signaling pathway	P00973	PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IDA	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00036	Interleukin signaling pathway	P00990	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	IGI	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00006	Apoptosis signaling pathway	P00274	JNK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01286	TGFbeta	RAT|RGD=1562986|UniProtKB=Q4AEG6	Bone morphogenetic protein 10	ISS	9759503	PubMed	PTHR11848:SF39	BONE MORPHOGENETIC PROTEIN 10
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	TAS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00647	SHP2	CANLF|Ensembl=ENSCAFG00000008894|UniProtKB=F1Q3J6	Tyrosine-protein phosphatase non-receptor type	ISS	14534538	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00916	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IPI	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00049	Parkinson disease	P01230	Src kinase	BOVIN|Ensembl=ENSBTAG00000011784|UniProtKB=A5PKG9	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF224	TYROSINE-PROTEIN KINASE FGR
P00059	p53 pathway	P04623	CBP	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P06212	DPP-SCW signaling pathway	P06271	MAD	DROME|FlyBase=FBgn0011648|UniProtKB=P42003	Protein mothers against dpp	IGI	7768443	PubMed	PTHR13703:SF40	PROTEIN MOTHERS AGAINST DPP
P04393	Ras Pathway	P04572	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	TAKRU|Ensembl=ENSTRUG00000016241|UniProtKB=H2UX35	Protein kinase C	ISS	11880265	PubMed	PTHR24356:SF305	PROTEIN KINASE C
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	HUMAN|HGNC=4579|UniProtKB=P39086	Glutamate receptor ionotropic, kainate 1	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00017	DNA replication	P00527	Histones	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g227545|UniProtKB=A7SVW3	Predicted protein	ISS	20448842	PubMed	PTHR11426:SF110	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00774	Dynein complex	ANOGA|EnsemblGenome=AGAP001672|UniProtKB=Q7PXZ5	AGAP001672-PA	IPI	9454836	PubMed	PTHR10676:SF36	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	MACMU|Ensembl=ENSMMUG00000010173|UniProtKB=F7AGU8	Presenilin	ISS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05913	Enkephalin release	P05972	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	MONDO|Ensembl=ENSMODG00000025146|UniProtKB=F7CLC0	Uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF311	CALMODULIN
P00005	Angiogenesis	P00206	Wnt	MOUSE|MGI=MGI=98958|UniProtKB=P22725	Protein Wnt-5a	ISS	8717036	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P04398	p53 pathway feedback loops 2	P04658	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00019	Endothelin signaling pathway	P00568	PKC	DANRE|ZFIN=ZDB-GENE-030131-6503|UniProtKB=Q7ZUC5	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF297	PROTEIN KINASE C DELTA TYPE
P00053	T cell activation	P01316	MHC-antigen	CANLF|Ensembl=ENSCAFG00000000803|UniProtKB=Q30437	MHC class II DR alpha chain	IPI	73139	PubMed	PTHR19944:SF63	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=1261834|UniProtKB=O70283	Protein Wnt-2b	TAS	12549854	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00089	Pen-2	DANRE|ZFIN=ZDB-GENE-040218-1|UniProtKB=Q8JHF0	Gamma-secretase subunit PEN-2	ISS	12110170	PubMed	PTHR16318:SF0	GAMMA-SECRETASE SUBUNIT PEN-2
P04396	Vitamin D metabolism and pathway	P04601	25-Hydroxylase	BOVIN|Ensembl=ENSBTAG00000016906|UniProtKB=E1BN35	Uncharacterized protein	ISS	11013342	PubMed	PTHR24291:SF3	25-HYDROXYVITAMIN D-1 ALPHA HYDROXYLASE, MITOCHONDRIAL
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	XENTR|Xenbase=XB-GENE-484003|UniProtKB=Q6P365	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00398	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00565	PKC	SCHPO|PomBase=SPBC12D12.04c|UniProtKB=P36583	Protein kinase C-like 2	IGI	125549	gi	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00029	Huntington disease	P00801	Fos protein	MONDO|Ensembl=ENSMODG00000005927|UniProtKB=F6WX28	Uncharacterized protein	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P02771	Pyrimidine Metabolism	P03126	Nucleoside Phosphorylase	THEMA|EnsemblGenome=TM_1653|UniProtKB=Q9S5X9	Pyrimidine-nucleoside phosphorylase	ISS	8824600	PubMed	PTHR10515:SF0	THYMIDINE PHOSPHORYLASE
P00006	Apoptosis signaling pathway	P00318	PKCs	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	PHYIT|EnsemblGenome=PITG_06376|UniProtKB=D0N4Q3	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta, putative	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00019	Endothelin signaling pathway	P00586	Gq	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00018	EGF receptor signaling pathway	P00559	MEK1-2	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IGI	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00021	FGF signaling pathway	P00648	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00036	Interleukin signaling pathway	P00970	Interleukin	MOUSE|MGI=MGI=107613|UniProtKB=P47873	Interleukin-11	IC			PTHR16922:SF0	INTERLEUKIN-11
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00627	ERK1-2	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	TAS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	TAKRU|Ensembl=ENSTRUG00000016241|UniProtKB=H2UX35	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF305	PROTEIN KINASE C
P05731	GABA-B receptor II signaling	P05754	Ggamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00021	FGF signaling pathway	P00632	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00222	VEGFR-2	PANTR|Ensembl=ENSPTRG00000016069|UniProtKB=H2QPH6	Uncharacterized protein	ISS	11824379	PubMed	PTHR24416:SF45	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2
P00021	FGF signaling pathway	P00633	Ras	DICPU|Gene=DICPUDRAFT_47179|UniProtKB=F0ZI47	Putative uncharacterized protein rasB	ISS	7997267	PubMed	PTHR24070:SF206	RAS-LIKE PROTEIN RASB
P00005	Angiogenesis	P00253	Axin	MOUSE|MGI=MGI=1096327|UniProtKB=O35625	Axin-1	ISS	12356903	PubMed	PTHR10845:SF11	AXIN-1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	IXOSC|EnsemblGenome=ISCW009711|UniProtKB=B7Q3T6	THO complex subunit, putative	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	ORYSJ|EnsemblGenome=OS01G0254900|UniProtKB=Q9S7H0	Os01g0254900 protein	IC			PTHR19957:SF38	T-SNARE DOMAIN-CONTAINING PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	CANLF|Ensembl=ENSCAFG00000018564|UniProtKB=E2RHU1	Uncharacterized protein	ISS	20112749	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00935	ILK	MONDO|Ensembl=ENSMODG00000018570|UniProtKB=F7FRN8	Uncharacterized protein	ISS			PTHR44344:SF1	INTEGRIN-LINKED PROTEIN KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00048	PI3 kinase pathway	P01199	Galpha	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00648	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00036	Interleukin signaling pathway	P00962	ELK	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	14670631	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00005	Angiogenesis	P00206	Wnt	RAT|RGD=69346|UniProtKB=G3V7U3	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CAEEL|WormBase=WBGene00004037|UniProtKB=Q9XWB7	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF9	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ORNAN|Ensembl=ENSOANG00000007716|UniProtKB=F6UDX9	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	BOVIN|Ensembl=ENSBTAG00000007047|UniProtKB=A3KMX5	FZD10 protein	ISS	11212302	PubMed	PTHR11309:SF86	FRIZZLED-10
P05918	p38 MAPK pathway	P06015	p38gamma	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00049	Parkinson disease	P01219	SAPK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00060	Ubiquitin proteasome pathway	P01491	E2	CHICK|Ensembl=ENSGALG00000006435|UniProtKB=E1BSI3	Uncharacterized protein	ISS			PTHR43898:SF6	UBIQUITIN-CONJUGATING ENZYME E2 B
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00005	Angiogenesis	P00220	c-Jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05916	Opioid prodynorphin pathway	P06000	vasopressin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P02740	De novo pyrimidine ribonucleotides biosythesis	P02928	Dihydroorotase	BACSU|EnsemblGenome=BSU15500|UniProtKB=P25995	Dihydroorotase	ISS			PTHR43668:SF1	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04556	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	CHICK|Ensembl=ENSGALG00000017238|UniProtKB=F1NWG3	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	LEIMA|EnsemblGenome=LmjF.04.1230|UniProtKB=Q9U1E8	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00005	Angiogenesis	P00189	Fzd	MONDO|Ensembl=ENSMODG00000011428|UniProtKB=F6RKF7	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF34	FRIZZLED-2
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	XENTR|Xenbase=XB-GENE-957248|UniProtKB=Q6GLE6	Serine/threonine-protein phosphatase	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00008	Axon guidance mediated by Slit/Robo	P00346	Sdf1	MOUSE|MGI=MGI=103556|UniProtKB=P40224	Stromal cell-derived factor 1	ISS			PTHR18837:SF3	STROMAL CELL-DERIVED FACTOR 1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	10553940	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00887	IRS 1-4	MACMU|Ensembl=ENSMMUG00000019467|UniProtKB=F6SUL3	Uncharacterized protein	ISS	5031805	gi	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00021	FGF signaling pathway	P00645	Rac	DICDI|dictyBase=DDB_G0279605|UniProtKB=P34148	Rho-related protein racB	ISS	4757952	gi	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IDA	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	IC	2372396	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=4401|UniProtKB=O14775	Guanine nucleotide-binding protein subunit beta-5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02753	Methionine biosynthesis	P03026	O-Succinyl homoserine lyase	FUSNN|EnsemblGenome=FN1745|UniProtKB=Q8RI68	Cystathionine gamma-synthase	ISS			PTHR11808:SF72	CYSTATHIONINE BETA LYASE
P00005	Angiogenesis	P00190	RasGAP	HUMAN|HGNC=9871|UniProtKB=P20936	Ras GTPase-activating protein 1	IDA	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00807	Actin	CHICK|Gene=ACTA2|UniProtKB=P08023	Actin, aortic smooth muscle	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00035	Interferon-gamma signaling pathway	P00958	PIAS	BOVIN|Ensembl=ENSBTAG00000021634|UniProtKB=A6QQU9	PIAS3 protein	ISS	8682149	PubMed	PTHR10782:SF10	E3 SUMO-PROTEIN LIGASE PIAS3
P00020	FAS signaling pathway	P00607	Pro-Caspase6	RAT|RGD=70967|UniProtKB=O35397	Caspase-6	ISS	10770929	PubMed	PTHR10454:SF164	CASPASE-6
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	PANTR|Ensembl=ENSPTRG00000020039|UniProtKB=H2R9W1	Uncharacterized protein	ISS	12135927	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05915	Opioid proenkephalin pathway	P05993	AC	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00011	Blood coagulation	P00429	PN2	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	ISS	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	ANOGA|EnsemblGenome=AGAP005912|UniProtKB=Q7Q6D3	AGAP005912-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	3755548	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P02770	Pyridoxal phosphate salvage pathway	P03122	Pyridoxamine kinase	YEAST|SGD=S000005310|UniProtKB=P53727	Putative pyridoxal kinase BUD17	ISS			PTHR10534:SF12	PYRIDOXAL KINASE BUD17-RELATED
P00053	T cell activation	P01305	Calmodulin	TAKRU|Ensembl=ENSTRUG00000003442|UniProtKB=H2S6Q5	Uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF197	CALMODULIN-LIKE PROTEIN 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	RAT|RGD=3238|UniProtKB=P01179	Oxytocin-neurophysin 1	ISS	1706187	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00059	p53 pathway	P04633	P110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	XENTR|Xenbase=XB-GENE-1004004|UniProtKB=F6VQZ5	Uncharacterized protein	ISS	14570579	PubMed	PTHR19957:SF90	SYNTAXIN-7
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	10218114	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00007	Axon guidance mediated by semaphorins	P00339	CRMP	XENTR|Xenbase=XB-GENE-944729|UniProtKB=Q6GL72	Dihydropyrimidinase-related protein 3	ISS	3122041	gi	PTHR11647:SF57	DIHYDROPYRIMIDINASE-RELATED PROTEIN 3
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MONDO|Ensembl=ENSMODG00000016603|UniProtKB=F6ZCX3	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF112	TUBULIN BETA-1 CHAIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00059	p53 pathway	P04633	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01192	p110	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=12774|UniProtKB=P04628	Proto-oncogene Wnt-1	TAS	14644163	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P02759	Pyridoxal-5-phosphate biosynthesis	P03062	1-Deoxyxylulose-5-phosphate synthase	SYNY3|EnsemblGenome=BAA17089|UniProtKB=P73067	1-deoxy-D-xylulose-5-phosphate synthase	ISS			PTHR43322:SF5	1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE 1-RELATED
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00005	Angiogenesis	P00236	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	PANTR|Ensembl=ENSPTRG00000002682|UniProtKB=H2Q259	S-adenosylmethionine synthase	ISS			PTHR11964:SF11	S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-1
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00021	FGF signaling pathway	P00640	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	ISS	96320556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00514	MLCK	MOUSE|MGI=MGI=2139434|UniProtKB=Q8VCR8	Myosin light chain kinase 2, skeletal/cardiac muscle	ISS	600922	OMIM	PTHR45210:SF1	MYOSIN LIGHT CHAIN KINASE 2, SKELETAL/CARDIAC MUSCLE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	HUMAN|HGNC=19663|UniProtKB=Q9UBI6	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IDA	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000001384|UniProtKB=F7GL73	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00053	T cell activation	P01306	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	HUMAN|HGNC=414|UniProtKB=P04075	Fructose-bisphosphate aldolase A	ISS	6086339	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00004	Alzheimer disease-presenilin pathway	P00114	actin	XENTR|GeneID=394982|UniProtKB=P20399	Actin, alpha cardiac muscle 2	ISS	14684598	PubMed	PTHR11937:SF263	ACTIN
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00029	Huntington disease	P00778	NMDA receptor	BOVIN|Ensembl=ENSBTAG00000000219|UniProtKB=F1MCL3	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00030	Hypoxia response via HIF activation	P00824	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	TAS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	IC	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00036	Interleukin signaling pathway	P00983	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IC	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	G06047	preprodynorphin	MOUSE|MGI=MGI=97535|UniProtKB=O35417	Proenkephalin-B	RCA	131330	OMIM	PTHR11438:SF4	PROENKEPHALIN-B
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000017374|UniProtKB=F7H6T7	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00019	Endothelin signaling pathway	P00572	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CANLF|Ensembl=ENSCAFG00000005662|UniProtKB=E2R907	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00017	DNA replication	P00527	Histones	CHICK|Ensembl=ENSGALG00000002286|UniProtKB=P84247	Histone H3.3	ISS	20448842	PubMed	PTHR11426:SF179	HISTONE H3.3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	TAS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02736	Coenzyme A biosynthesis	P02885	Pantothenate kinase	BOVIN|Ensembl=ENSBTAG00000011895|UniProtKB=Q08DA5	Pantothenate kinase 3	ISS			PTHR12280:SF21	PANTOTHENATE KINASE 3
P00052	TGF-beta signaling pathway	P01286	TGFbeta	XENTR|Xenbase=XB-GENE-487309|UniProtKB=Q66KL4	Derriere protein	ISS	10844590	PubMed	PTHR11848:SF151	EMBRYONIC GROWTH/DIFFERENTIATION FACTOR 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00005	Angiogenesis	P00234	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	8262390	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	RCA	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00916	Ras	DAPPU|EnsemblGenome=DAPPUDRAFT_301818|UniProtKB=E9I1I7	Putative uncharacterized protein	ISS	20148920	PubMed	PTHR24070:SF385	GTPASE HRAS
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000017612|UniProtKB=C7G3N0	Glutamate receptor, metabotropic 6	ISS	9407094	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	EMENI|EnsemblGenome=CADANIAG00002670|UniProtKB=Q5BH99	G-protein beta subunit [Source:UniProtKB/TrEMBLAcc:O74214]	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00054	Toll receptor signaling pathway	P01375	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01471	alpha-catenin	DANRE|Ensembl=ENSDARG00000024785|UniProtKB=B7ZC77	Catenin alpha-2	ISS	1638632	PubMed	PTHR18914:SF29	CATENIN ALPHA-2
P00006	Apoptosis signaling pathway	P00269	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	XENTR|Xenbase=XB-GENE-6067221|UniProtKB=F6Z0J4	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04393	Ras Pathway	P04557	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00021	FGF signaling pathway	P00624	14-3-3	MONDO|Ensembl=ENSMODG00000006158|UniProtKB=F7BS95	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00054	Toll receptor signaling pathway	P01369	MKK1	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00020	FAS signaling pathway	P00601	c-Jun	XENTR|Xenbase=XB-GENE-482228|UniProtKB=F6RYL1	Uncharacterized protein	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00049	Parkinson disease	P01227	20S proteasome	TRYB2|Gene=Tb10.100.0170|UniProtKB=Q38CK9	Proteasome subunit alpha type	TAS	12859888	PubMed	PTHR11599:SF16	PROTEASOME SUBUNIT ALPHA TYPE-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00009	Axon guidance mediated by netrin	P00364	cdc42	XENTR|Xenbase=XB-GENE-491190|UniProtKB=F6Y381	Uncharacterized protein	ISS			PTHR24072:SF145	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00785	Cytochrome c	LEIMA|EnsemblGenome=LmjF.07.0060|UniProtKB=Q4QIT8	Putative cytochrome c1, heme protein,mitochondrial	ISS	9027315	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00010	B cell activation	P00373	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	AQUAE|EnsemblGenome=aq_1154|UniProtKB=O67222	S-adenosylmethionine synthase	ISS			PTHR11964:SF1	S-ADENOSYLMETHIONINE SYNTHASE
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8704|UniProtKB=Q9Y5G7	Protocadherin gamma-A6	IDA	8120095	PubMed	PTHR24028:SF107	PROTOCADHERIN GAMMA-A6
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=62087|UniProtKB=P27704	Mitogen-activated protein kinase 6	ISS	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00006	Apoptosis signaling pathway	P00297	NFkappaB	MACMU|Ensembl=ENSMMUG00000003736|UniProtKB=F7HKH9	Nuclear factor NF-kappa-B p105 subunit isoform 1	ISS	12574369	PubMed	PTHR24169:SF9	NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	DANRE|ZFIN=ZDB-GENE-990415-224|UniProtKB=F1QBI2	Uncharacterized protein	TAS	11212302	PubMed	PTHR11309:SF34	FRIZZLED-2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00011	Blood coagulation	P00438	Bradykinin	MACMU|Ensembl=ENSMMUG00000003700|UniProtKB=F6SG43	Uncharacterized protein	ISS	386852	gi	PTHR13814:SF12	KININOGEN-1
P05915	Opioid proenkephalin pathway	P05993	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00036	Interleukin signaling pathway	P00964	p90RSK	MOUSE|MGI=MGI=104557|UniProtKB=P18654	Ribosomal protein S6 kinase alpha-3	IDA	10480933	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00047	PDGF signaling pathway	P01159	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00021	FGF signaling pathway	P00627	ERK1-2	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	ISS	1319556	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00025	Hedgehog signaling pathway	P00682	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00566	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01330	IKK	MACMU|Ensembl=ENSMMUG00000018476|UniProtKB=F6X938	Uncharacterized protein	ISS	12813046	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P04393	Ras Pathway	P04565	MKK4/7	MONDO|Ensembl=ENSMODG00000014960|UniProtKB=F7D0A6	Uncharacterized protein	ISS	15039780	PubMed	PTHR24361:SF387	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7
P00049	Parkinson disease	P01211	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	21186066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00983	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02723	Adenine and hypoxanthine salvage pathway	P02805	Adenine phosphorylase	MOUSE|MGI=MGI=3712328|UniProtKB=Q9D8C9	Purine nucleoside phosphorylase	ISS	7903568	PubMed	PTHR11904:SF12	PURINE NUCLEOSIDE PHOSPHORYLASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	CHICK|Ensembl=ENSGALG00000006540|UniProtKB=F1NW19	Uncharacterized protein	ISS			PTHR43893:SF13	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00648	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IGI	3045562	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DANRE|ZFIN=ZDB-GENE-040426-1489|UniProtKB=Q6PHV0	Syntaxin 3A	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00021	FGF signaling pathway	P00627	ERK1-2	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	BOVIN|Ensembl=ENSBTAG00000018425|UniProtKB=Q3ZBD0	26S proteasome non-ATPase regulatory subunit 7	ISS			PTHR10540:SF7	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7
P00019	Endothelin signaling pathway	P00588	ET1-4	DANRE|ZFIN=ZDB-GENE-000920-1|UniProtKB=A5WW41	Uncharacterized protein	ISS	20393975	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	91056091	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02771	Pyrimidine Metabolism	P03124	Methylmalonate Semialdehyde Dehydrogenase	CANLF|Ensembl=ENSCAFG00000016901|UniProtKB=J9P2I9	Uncharacterized protein	ISS	2708830	gi	PTHR43866:SF3	METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE  ACYLATING , MITOCHONDRIAL
P00048	PI3 kinase pathway	P01199	Galpha	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IC	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00005	Angiogenesis	P00224	PDGF	RAT|RGD=3282|UniProtKB=P28576	Platelet-derived growth factor subunit A	ISS			PTHR11633:SF3	PLATELET-DERIVED GROWTH FACTOR SUBUNIT A
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MACMU|Ensembl=ENSMMUG00000018344|UniProtKB=F7H617	Uncharacterized protein	ISS			PTHR13140:SF379	UNCONVENTIONAL MYOSIN-XV
P00047	PDGF signaling pathway	P01162	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00009	Axon guidance mediated by netrin	P00366	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	15470041	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	TAS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	MACMU|Ensembl=ENSMMUG00000022893|UniProtKB=F6WF14	Uncharacterized protein	ISS	193400	OMIM	PTHR11339:SF361	VON WILLEBRAND FACTOR-RELATED
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00010	B cell activation	P00391	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	RAT|RGD=3251|UniProtKB=Q62829	Serine/threonine-protein kinase PAK 3	ISS	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IGI	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	TAKRU|Ensembl=ENSTRUG00000002793|UniProtKB=H2S271	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF676	MYOSIN, HEAVY POLYPEPTIDE 2, FAST MUSCLE SPECIFIC
P00005	Angiogenesis	P00251	cPLA2	PANTR|Ensembl=ENSPTRG00000011223|UniProtKB=H2QGQ4	Uncharacterized protein	ISS			PTHR10728:SF39	CYTOSOLIC PHOSPHOLIPASE A2 GAMMA
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00059	p53 pathway	P04626	GADD45	RAT|RGD=2654|UniProtKB=P48317	Growth arrest and DNA damage-inducible protein GADD45 alpha	IGI	10097101	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P04393	Ras Pathway	P04546	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	CANLF|Ensembl=ENSCAFG00000008756|UniProtKB=F2Z4N8	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	8170357	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05916	Opioid prodynorphin pathway	P06002	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=98328|UniProtKB=P30875	Somatostatin receptor type 2	ISS	12441358	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P00019	Endothelin signaling pathway	P00570	PKA	NEUCR|EnsemblGenome=EFNCRG00000004240|UniProtKB=Q01386	cAMP-dependent protein kinase regulatory subunit	IGI	97076137	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04658	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00642	MEK1-2	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00047	PDGF signaling pathway	P01165	SRF	CANLF|Ensembl=ENSCAFG00000001829|UniProtKB=F1PH12	Uncharacterized protein	ISS	8660892	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00037	Ionotropic glutamate receptor pathway	P01026	KA	ORNAN|Ensembl=ENSOANG00000010302|UniProtKB=F6TDQ6	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00038	JAK/STAT signaling pathway	P01027	STAT	CHICK|Ensembl=ENSGALG00000003267|UniProtKB=Q6DV79	Signal transducer and activator of transcription 3	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00052	TGF-beta signaling pathway	P01286	TGFbeta	PANTR|Ensembl=ENSPTRG00000016807|UniProtKB=H2R5I7	Uncharacterized protein	ISS	10779363	PubMed	PTHR12173:SF1	GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00049	Parkinson disease	P01219	SAPK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000014576|UniProtKB=H2QLZ9	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00047	PDGF signaling pathway	P01168	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00020	FAS signaling pathway	P00601	c-Jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02775	Salvage pyrimidine ribonucleotides	P03156	CDP kinase	CAEEL|WormBase=WBGene00008948|UniProtKB=H2L2A8	Uridine kinase	ISS			PTHR10285:SF123	URIDINE KINASE
P00021	FGF signaling pathway	P00624	14-3-3	CAEBR|Gene=CBG06174|UniProtKB=A8X0R4	Protein CBR-PAR-5	ISS	21643941	PubMed	PTHR18860:SF21	14-3-3-LIKE PROTEIN 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TRYB2|Gene=Tb09.211.0620|UniProtKB=Q38E94	Actin A	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	DROME|FlyBase=FBgn0000150|UniProtKB=P08879	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	RCA	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CAEBR|Gene=CBG17587|UniProtKB=A8XRA5	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IDA	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	NAS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	MOUSE|MGI=MGI=1924885|UniProtKB=Q9JLY0	Suppressor of cytokine signaling 6	TAS	15032587	PubMed	PTHR44562:SF1	SUPPRESSOR OF CYTOKINE SIGNALING 6
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05915	Opioid proenkephalin pathway	P05994	G-protein	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P02738	De novo purine biosynthesis	P02909	GDP reductase	MYCTU|EnsemblGenome=Rv1981c|UniProtKB=P9WH73	Ribonucleoside-diphosphate reductase subunit beta nrdF1	ISS			PTHR23409:SF32	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT BETA
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00036	Interleukin signaling pathway	P00990	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00788	Calpain	MACMU|Ensembl=ENSMMUG00000011142|UniProtKB=F6TJJ5	Uncharacterized protein	ISS	11675509	PubMed	PTHR10183:SF268	CALPAIN-2 CATALYTIC SUBUNIT
P05913	Enkephalin release	P05977	G-Protein (s)	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00049	Parkinson disease	P01208	Hsp70	HUMAN|HGNC=5238|UniProtKB=P11021	78 kDa glucose-regulated protein	IDA	10934466	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00025	Hedgehog signaling pathway	P00682	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00298	Caspase 9	MACMU|Ensembl=ENSMMUG00000018163|UniProtKB=F7FNC1	Caspase	ISS	9390557	PubMed	PTHR10454:SF157	CASPASE-9
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MOUSE|MGI=MGI=95814|UniProtKB=Q60934	Glutamate receptor ionotropic, kainate 1	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02725	Allantoin degradation	P02822	Allantoinase	STRCO|EnsemblGenome=CAB60166|UniProtKB=Q9RKU5	Allantoinase	ISS			PTHR43668:SF2	ALLANTOINASE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00029	Huntington disease	P00793	Arfaptin-2	PANTR|Ensembl=ENSPTRG00000003291|UniProtKB=H2Q322	ADP-ribosylation factor interacting protein 2	ISS	11854752	PubMed	PTHR12141:SF3	ARFAPTIN-2
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P06959	CCKR signaling map	P07227	KLF4	HUMAN|HGNC=6348|UniProtKB=O43474	Krueppel-like factor 4	RCA	9142914	PubMed	PTHR44778:SF1	KRUEPPEL-LIKE FACTOR 4
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00019	Endothelin signaling pathway	P00566	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	97102671	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00060	Ubiquitin proteasome pathway	P01492	E1	RAT|RGD=1306098|UniProtKB=Q6AXQ0	SUMO-activating enzyme subunit 1	ISS			PTHR10953:SF162	SUMO-ACTIVATING ENZYME SUBUNIT 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	BOVIN|Ensembl=ENSBTAG00000012687|UniProtKB=F1MV64	Tyrosine-protein kinase receptor	ISS	14500580	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00859	NFkappaB	MOUSE|MGI=MGI=104741|UniProtKB=Q9Z1E3	NF-kappa-B inhibitor alpha	ISS			PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	ANOGA|EnsemblGenome=AGAP002578|UniProtKB=F5HKU8	AGAP002578-PB	ISS	14624853	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	TAS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00899	IRS 1-4	CANLF|Ensembl=ENSCAFG00000010397|UniProtKB=E2RDB5	Uncharacterized protein	ISS	1311924	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	PANTR|Ensembl=ENSPTRG00000008260|UniProtKB=H2QBD7	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	ISS	9462517	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00057	Wnt signaling pathway	P01452	NFAT	RAT|RGD=1307690|UniProtKB=D4A0I8	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (Predicted), isoform CRA_b	ISS	12787506	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2050|UniProtKB=P29276	Adenosine receptor A2b	IDA			PTHR24246:SF18	ADENOSINE RECEPTOR A2B
P00018	EGF receptor signaling pathway	P00565	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00644	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00004	Alzheimer disease-presenilin pathway	P00148	Erb-B4 N-terminal fragment	CHICK|Ensembl=ENSGALG00000003126|UniProtKB=F1P258	Receptor protein-tyrosine kinase	ISS	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	PHYIT|EnsemblGenome=PITG_06376|UniProtKB=D0N4Q3	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta, putative	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00005	Angiogenesis	P00207	Crk	CAEEL|WormBase=WBGene00000416|UniProtKB=Q9NHC3	Cell death abnormality protein 2	ISS			PTHR19969:SF5	ADAPTER MOLECULE CRK
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00050	Plasminogen activating cascade	P01246	Plasmin	PANTR|Ensembl=ENSPTRG00000018774|UniProtKB=H2QU06	Plasminogen	ISS	130317	gi	PTHR24261:SF6	PLASMINOGEN
P06664	Gonadotropin-releasing hormone receptor pathway	P06777	NFAT	MOUSE|MGI=MGI=102463|UniProtKB=Q60591	Nuclear factor of activated T-cells, cytoplasmic 2	RCA			PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00036	Interleukin signaling pathway	P00976	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS			PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	PANTR|Ensembl=ENSPTRG00000007231|UniProtKB=H2Q9Q1	Uncharacterized protein	ISS	9783586	PubMed	PTHR10814:SF24	TRANSDUCIN-LIKE ENHANCER PROTEIN 3
P04393	Ras Pathway	P04558	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IDA	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	XENTR|Xenbase=XB-GENE-942662|UniProtKB=F6X8Y6	Aldehyde dehydrogenase	ISS	14724059	PubMed	PTHR43570:SF9	FATTY ALDEHYDE DEHYDROGENASE
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00036	Interleukin signaling pathway	P00965	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01192	p110	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ANOGA|EnsemblGenome=AGAP000651|UniProtKB=P84185	Actin-5C	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	IC	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04395	Vasopressin synthesis	P04590	Vasopressin	MACMU|Ensembl=ENSMMUG00000010678|UniProtKB=F7AXI7	Uncharacterized protein	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00048	PI3 kinase pathway	P01185	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00018	EGF receptor signaling pathway	P00565	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00030	Hypoxia response via HIF activation	P00819	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00017	DNA replication	P00535	5' to 3' Exoribonulcease	MACMU|Ensembl=ENSMMUG00000011405|UniProtKB=F6VZ85	Uncharacterized protein	ISS	7885830	PubMed	PTHR12341:SF41	5'-3' EXORIBONUCLEASE 2
P00025	Hedgehog signaling pathway	P00692	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00029	Huntington disease	P00807	Actin	DANRE|ZFIN=ZDB-GENE-040625-35|UniProtKB=Q6IQL9	Novel actin protein	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00010	B cell activation	P00383	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00057	Wnt signaling pathway	P01451	Galpha	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05916	Opioid prodynorphin pathway	P05997	prodynorphin	MOUSE|MGI=MGI=97535|UniProtKB=O35417	Proenkephalin-B	RCA	131330	OMIM	PTHR11438:SF4	PROENKEPHALIN-B
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00137	Tip60	XENTR|Xenbase=XB-GENE-488776|UniProtKB=F6UKT0	Histone acetyltransferase (Fragment)	ISS			PTHR10615:SF102	HISTONE ACETYLTRANSFERASE KAT7
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	CHLTR|EnsemblGenome=CT_128|UniProtKB=O84130	Adenylate kinase	ISS			PTHR23359:SF22	GTP:AMP PHOSPHOTRANSFERASE, MITOCHONDRIAL
P00005	Angiogenesis	P00206	Wnt	DANRE|ZFIN=ZDB-GENE-980526-416|UniProtKB=Q92048	Protein Wnt-2	ISS	8717036	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00057	Wnt signaling pathway	P01438	PP2A	PANTR|Ensembl=ENSPTRG00000003853|UniProtKB=H2Q411	Protein phosphatase 2, regulatory subunit B', beta	ISS	10092233	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MACMU|Ensembl=ENSMMUG00000007445|UniProtKB=F6SWI4	Uncharacterized protein	ISS	20088160	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	HUMAN|HGNC=8568|UniProtKB=P09958	Furin	IDA	11861638	PubMed	PTHR42884:SF1	FURIN
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	CAEBR|Gene=CBG06179|UniProtKB=A8X0Q9	Serine/threonine-protein phosphatase	ISS			PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01298	NFkappaB	MOUSE|MGI=MGI=97312|UniProtKB=P25799	Nuclear factor NF-kappa-B p105 subunit	IGI	11739545	PubMed	PTHR24169:SF9	NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT
P00053	T cell activation	P01332	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	MACMU|Ensembl=ENSMMUG00000005008|UniProtKB=F6VJI3	Cyclic AMP-responsive element-binding protein 3-like protein 4	RCA			PTHR22952:SF105	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 4
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00046	Oxidative stress response	P01131	MKP5	MOUSE|MGI=MGI=1927070|UniProtKB=Q9ESS0	Dual specificity protein phosphatase 10	TAS	11856337	PubMed	PTHR10159:SF299	DUAL SPECIFICITY PROTEIN PHOSPHATASE 10
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000018677|UniProtKB=H2QTV4	Syntaxin 11	ISS	11067767	PubMed	PTHR19957:SF30	SYNTAXIN-11
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000006307|UniProtKB=H2SSM1	Uncharacterized protein	IC			PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	ARATH|TAIR=AT2G44680|UniProtKB=O80507	Putative casein kinase II subunit beta-4	IDA	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00047	PDGF signaling pathway	P01173	STAT	BOVIN|Ensembl=ENSBTAG00000006335|UniProtKB=F1MGJ4	Signal transducer and activator of transcription	ISS	94367369	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	SCLS1|Gene=SS1G_08733|UniProtKB=A7ETS6	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	MOUSE|MGI=MGI=1339984|UniProtKB=Q8CIN4	Serine/threonine-protein kinase PAK 2	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P02748	Isoleucine biosynthesis	P02995	Threonine dehydratase	MYCTU|EnsemblGenome=Rv1559|UniProtKB=P9WG95	L-threonine dehydratase biosynthetic IlvA	ISS			PTHR43714:SF1	THREONINE DEHYDRATASE, MITOCHONDRIAL
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=1346347|UniProtKB=Q9WVS8	Mitogen-activated protein kinase 7	IPI	15085193	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000011757|UniProtKB=Q9XT97	Presenilin-1	IDA	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00030	Hypoxia response via HIF activation	P00819	AKT	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	20855874	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CANLF|Ensembl=ENSCAFG00000017522|UniProtKB=Q076A4	Myosin-8	ISS	89264452	PubMed	PTHR13140:SF368	MYOSIN-8
P00049	Parkinson disease	P01236	Casein kinase II	RAT|RGD=1306882|UniProtKB=B4F7A9	Casein kinase 2, alpha prime polypeptide	ISS	10617630	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IDA	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	RCA	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04542	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	XENTR|Xenbase=XB-GENE-5801166|UniProtKB=F6ZE26	Uncharacterized protein	ISS	8576107	PubMed	PTHR24070:SF382	RAS-RELATED PROTEIN RAP-1B
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	ORNAN|Ensembl=ENSOANG00000003489|UniProtKB=F7FSE3	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00009	Axon guidance mediated by netrin	P00360	DCC/UNC-40	CANLF|Ensembl=ENSCAFG00000000157|UniProtKB=F1PAZ4	Uncharacterized protein	ISS	8861902	PubMed	PTHR44146:SF3	NETRIN RECEPTOR DCC
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	HUMAN|HGNC=2090|UniProtKB=P09496	Clathrin light chain A	IDA	9388255	PubMed	PTHR10639:SF1	CLATHRIN LIGHT CHAIN A
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05918	p38 MAPK pathway	P06013	ELK	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	RCA	3183861	gi	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00047	PDGF signaling pathway	P01164	PDK1/2	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	ISS	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	IDA	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IDA	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	15210700	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04573	Elk-1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	IDA	9644975	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P04373	5HT1 type receptor mediated signaling pathway	P04409	5HT transporter	BOVIN|Gene=SLC6A4|UniProtKB=Q9XT49	Sodium-dependent serotonin transporter	IEA	7681602	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P00012	Cadherin signaling pathway	P00470	F-actin	XENTR|Xenbase=XB-GENE-488998|UniProtKB=Q5BL41	Actin-related protein 2	ISS	10974003	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00012	Cadherin signaling pathway	P00470	F-actin	CANAL|CGD=CAL0064759|UniProtKB=Q5AKX0	Uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05918	p38 MAPK pathway	P06021	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12874273	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00047	PDGF signaling pathway	P01160	IP3 receptor	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00005	Angiogenesis	P00204	PLD	RAT|RGD=3349|UniProtKB=P70496	Phospholipase D1	ISS	15668389	PubMed	PTHR18896:SF57	PHOSPHOLIPASE D1
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	HUMAN|HGNC=10939|UniProtKB=P43005	Excitatory amino acid transporter 3	ISS	94365697	PubMed	PTHR11958:SF69	EXCITATORY AMINO ACID TRANSPORTER 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00034	Integrin signalling pathway	P00912	Arp2/3	BOVIN|Ensembl=ENSBTAG00000004242|UniProtKB=Q1JP79	Actin-related protein 2/3 complex subunit 1A	ISS	12932731	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00029	Huntington disease	P00780	Microtubule	SCHMA|EnsemblGenome=Smp_079960|UniProtKB=G4VTA4	Putative tubulin beta chain	ISS	9454836	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00005	Angiogenesis	P00217	STAT3	RAT|RGD=3772|UniProtKB=P52631	Signal transducer and activator of transcription 3	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00005	Angiogenesis	P00183	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	95096035	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00047	PDGF signaling pathway	P01148	Grb2	DANRE|ZFIN=ZDB-GENE-040426-1975|UniProtKB=Q6PC73	Growth factor receptor-bound protein 2	ISS	http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd	Website	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANAL|CGD=CAL0068551|UniProtKB=Q5AAR9	Phosphatidylinositol 3-kinase	ISS	10870104	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05916	Opioid prodynorphin pathway	P05999	provasopressin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P05913	Enkephalin release	P05974	G-Protein (i)	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05916	Opioid prodynorphin pathway	P06002	G-protein	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P02770	Pyridoxal phosphate salvage pathway	P03121	Pyridoxal kinase	SCHPO|PomBase=SPCC18.10|UniProtKB=O74860	Putative pyridoxal kinase C18.10	ISS	11859360	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	TAS	9603989	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	HUMAN|HGNC=667|UniProtKB=P61586	Transforming protein RhoA	ISS	12169092	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	RCA	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=107717|UniProtKB=Q8VDD5	Myosin-9	IC	89264452	PubMed	PTHR13140:SF317	MYOSIN-9
P00047	PDGF signaling pathway	P01172	c-Myc	MOUSE|MGI=MGI=97250|UniProtKB=P01108	Myc proto-oncogene protein	ISS	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	ARATH|TAIR=AT3G05840|UniProtKB=P43289	Shaggy-related protein kinase gamma	IDA			PTHR24057:SF13	SHAGGY-RELATED PROTEIN KINASE ALPHA-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000008719|UniProtKB=F1MZX0	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	NEMVE|Gene=v1g88970|UniProtKB=A7RPN8	Predicted protein (Fragment)	ISS	3885394	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00023	General transcription regulation	P00662	TFIIA complex	DROME|FlyBase=FBgn0040338|UniProtKB=Q9W5B9	Transcription initiation factor IIA subunit 2-2	ISS			PTHR10966:SF0	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	RCA	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00048	PI3 kinase pathway	P01190	PDK1 ACT	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	9094314	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00034	Integrin signalling pathway	P00938	Cdc42	DROME|FlyBase=FBgn0010341|UniProtKB=P40793	Cdc42 homolog	IDA	4757952	gi	PTHR24072:SF192	CDC42 HOMOLOG
P00036	Interleukin signaling pathway	P00965	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04578	Rho	MOUSE|MGI=MGI=106028|UniProtKB=Q62159	Rho-related GTP-binding protein RhoC	IDA	14871999	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00034	Integrin signalling pathway	P00916	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IPI	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00005	Angiogenesis	P00190	RasGAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05726	2-arachidonoylglycerol biosynthesis	P05736	DGL	RAT|RGD=1359461|UniProtKB=Q5YLM1	Sn1-specific diacylglycerol lipase alpha	RCA			PTHR21493:SF164	SN1-SPECIFIC DIACYLGLYCEROL LIPASE ALPHA
P00057	Wnt signaling pathway	P01465	Ggamma	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00053	T cell activation	P01332	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MOUSE|MGI=MGI=107179|UniProtKB=P48755	Fos-related antigen 1	ISS	10664585	PubMed	PTHR23351:SF6	FOS-RELATED ANTIGEN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	BOVIN|Ensembl=ENSBTAG00000004368|UniProtKB=F1MSU2	Uncharacterized protein	ISS	12787506	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01167	Ets	MACMU|Ensembl=ENSMMUG00000000780|UniProtKB=F6RBL2	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF203	PROTEIN FEV
P00020	FAS signaling pathway	P00594	Caspase8	PANTR|Ensembl=ENSPTRG00000012798|UniProtKB=H2R695	CASP8 and FADD-like apoptosis regulator	ISS	9211860	PubMed	PTHR10454:SF8	CASP8 AND FADD-LIKE APOPTOSIS REGULATOR
P00036	Interleukin signaling pathway	P00983	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02727	Androgen/estrogene/progesterone biosynthesis	P02829	Cholesterol acyltransferase	PANTR|Ensembl=ENSPTRG00000001728|UniProtKB=H2Q0P3	O-acyltransferase	ISS	9756918	PubMed	PTHR10408:SF6	STEROL O-ACYLTRANSFERASE 1
P06959	CCKR signaling map	P07121	MAP2K2	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	RCA	9230117	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00566	ERK	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	NAS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01194	S6K	ORNAN|Ensembl=ENSOANG00000002226|UniProtKB=F6TPX7	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00048	PI3 kinase pathway	P01199	Galpha	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IC	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P06664	Gonadotropin-releasing hormone receptor pathway	P06831	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	RCA	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00016	Cytoskeletal regulation by Rho GTPase	P00507	Rho	MONDO|Ensembl=ENSMODG00000000981|UniProtKB=F7ES59	Uncharacterized protein	ISS	12090470	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CAEBR|Gene=CBG05858|UniProtKB=A8X1H0	Protein CBR-EGL-19 (Fragment)	ISS	8838325	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00833	RGS	HUMAN|HGNC=10000|UniProtKB=P49798	Regulator of G-protein signaling 4	ISS	8756726	PubMed	PTHR10845:SF184	REGULATOR OF G-PROTEIN SIGNALING 4
P00001	Adrenaline and noradrenaline biosynthesis	P00061	PNMT	MACMU|Ensembl=ENSMMUG00000007086|UniProtKB=F7ERX8	Uncharacterized protein	ISS			PTHR10867:SF5	NICOTINAMIDE N-METHYLTRANSFERASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02769	Purine metabolism	P03116	Xanthine Oxidase	EMENI|EnsemblGenome=CADANIAG00003457|UniProtKB=Q12553	Xanthine dehydrogenase	TAS	7876088	PubMed	PTHR11908:SF100	XANTHINE DEHYDROGENASE
P00057	Wnt signaling pathway	P01446	Calcineurin	MACMU|Ensembl=ENSMMUG00000014442|UniProtKB=F7BBG8	Serine/threonine-protein phosphatase	ISS	12015605	PubMed	PTHR11668:SF186	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT GAMMA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04572	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	IDA	10514528	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02738	De novo purine biosynthesis	P02891	GDP kinase	ARATH|TAIR=AT4G09320|UniProtKB=P39207	Nucleoside diphosphate kinase 1	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000004474|UniProtKB=E2RCN6	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00058	mRNA splicing	P01476	U4	BOVIN|Gene=PRPF3|UniProtKB=Q2KIA6	U4/U6 small nuclear ribonucleoprotein Prp3	ISS	9328476	PubMed	PTHR14212:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	TAS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00632	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P05998	Kappa Receptor	MOUSE|MGI=MGI=97439|UniProtKB=P33534	Kappa-type opioid receptor	RCA	11259487	PubMed	PTHR24229:SF1	KAPPA-TYPE OPIOID RECEPTOR
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	XENTR|Xenbase=XB-GENE-484098|UniProtKB=F6ZQ88	Protein Wnt (Fragment)	ISS	8717036	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00046	Oxidative stress response	P01135	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P02788	Xanthine and guanine salvage pathway	P03249	Guanine deaminase	MACMU|Ensembl=ENSMMUG00000019196|UniProtKB=F7CWS1	Guanine deaminase isoform b	ISS	11837778	gi	PTHR11271:SF6	GUANINE DEAMINASE
P00018	EGF receptor signaling pathway	P00564	Rac	DICPU|Gene=DICPUDRAFT_92985|UniProtKB=F1A084	Putative uncharacterized protein rac1A	ISS	21127961	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-2280|UniProtKB=Q6P025	Gnb3 protein	ISS			PTHR19850:SF35	GNB3 PROTEIN
P00005	Angiogenesis	P00226	Delta/Serrate	ORNAN|Ensembl=ENSOANG00000008425|UniProtKB=F6VUQ4	Delta-like protein	ISS	12826675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00025	Hedgehog signaling pathway	P00682	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	IDA	14744463	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT1G73670|UniProtKB=Q9C9U4	Mitogen-activated protein kinase 15	IDA			PTHR24055:SF246	MITOGEN-ACTIVATED PROTEIN KINASE 15-RELATED
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	RAT|RGD=619731|UniProtKB=Q9QYP1	Low-density lipoprotein receptor-related protein 4	ISS	11907044	PubMed	PTHR44017:SF4	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4
P00012	Cadherin signaling pathway	P00462	Casein kinase II	CHICK|Ensembl=ENSGALG00000006197|UniProtKB=P21868	Casein kinase II subunit alpha	ISS	10617630	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00059	p53 pathway	P04609	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	CANLF|Ensembl=ENSCAFG00000015856|UniProtKB=J9P3S5	Nucleoside diphosphate kinase	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P00019	Endothelin signaling pathway	P00566	ERK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	SCHPO|PomBase=SPAC29E6.08|UniProtKB=P17871	TATA-box-binding protein	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P06664	Gonadotropin-releasing hormone receptor pathway	P06739	MEK1/2	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	RCA	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT3G14720|UniProtKB=Q9LUC3	Mitogen-activated protein kinase 19	ISS	12787066	PubMed	PTHR24055:SF200	MITOGEN-ACTIVATED PROTEIN KINASE 18-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DROME|FlyBase=FBgn0000042|UniProtKB=P10987	Actin-5C	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00017	DNA replication	P00527	Histones	MONDO|Ensembl=ENSMODG00000023580|UniProtKB=F7C8E5	Histone H3	ISS	12413958	PubMed	PTHR11426:SF184	HISTONE H3.1T
P00019	Endothelin signaling pathway	P00568	PKC	YEAST|SGD=S000000201|UniProtKB=P24583	Protein kinase C-like 1	ISS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00037	Ionotropic glutamate receptor pathway	P01001	KA4	MACMU|Ensembl=ENSMMUG00000022347|UniProtKB=F6ZCH5	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00057	Wnt signaling pathway	P01448	CBP	BOVIN|Ensembl=ENSBTAG00000016198|UniProtKB=E1B8D6	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00005	Angiogenesis	P00211	GSK3beta	STRPU|EnsemblGenome=SPU_009263|UniProtKB=W4Y0P1	Uncharacterized protein	ISS			PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00021	FGF signaling pathway	P00645	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00047	PDGF signaling pathway	P01150	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00047	PDGF signaling pathway	P01142	p90RSK	MACMU|Ensembl=ENSMMUG00000020532|UniProtKB=F7D8E6	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF98	RIBOSOMAL PROTEIN S6 KINASE ALPHA-6
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02748	Isoleucine biosynthesis	P02997	Acetolactate synthase	SULSO|EnsemblGenome=SSO0579|UniProtKB=Q7LXT8	Acetolactate synthase	ISS			PTHR18968:SF13	ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	TAKRU|Ensembl=ENSTRUG00000013071|UniProtKB=H2U8B2	Uncharacterized protein (Fragment)	ISS	85270494	PubMed	PTHR18945:SF489	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-9
P05912	Dopamine receptor mediated signaling pathway	P05955	DBH	DROME|FlyBase=FBgn0010329|UniProtKB=Q86B61	Tyramine beta-hydroxylase	ISS	90219125	PubMed	PTHR10157:SF29	DOPAMINE BETA-HYDROXYLASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04586	ProTRH (Pro Thyrotropin-releasing Hormone)	MACMU|Ensembl=ENSMMUG00000005160|UniProtKB=F7D5R6	Uncharacterized protein	ISS	2126343	PubMed	PTHR17530:SF2	PRO-THYROTROPIN-RELEASING HORMONE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	MOUSE|MGI=MGI=88460|UniProtKB=Q02788	Collagen alpha-2(VI) chain	IC	10778855	PubMed	PTHR44172:SF1	COLLAGEN ALPHA-2 VI  CHAIN
P06664	Gonadotropin-releasing hormone receptor pathway	P06787	SMAD1/5/8	MOUSE|MGI=MGI=1328787|UniProtKB=P97454	Mothers against decapentaplegic homolog 5	RCA	12736218	PubMed	PTHR13703:SF36	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00777	CBP	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P02775	Salvage pyrimidine ribonucleotides	P03151	Uracil phosphoribosyl  transferase	PYRAE|EnsemblGenome=PAE1598|UniProtKB=Q8ZWV9	Uracil phosphoribosyltransferase	ISS			PTHR10285:SF46	URACIL PHOSPHORIBOSYLTRANSFERASE, CHLOROPLASTIC
P00019	Endothelin signaling pathway	P00586	Gq	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01160	IP3 receptor	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	DROME|FlyBase=FBgn0002938|UniProtKB=P10676	Neither inactivation nor afterpotential protein C	ISS			PTHR13140:SF666	NEITHER INACTIVATION NOR AFTERPOTENTIAL PROTEIN C
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00029	Huntington disease	P00807	Actin	ORNAN|Ensembl=ENSOANG00000000460|UniProtKB=F7F4W9	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TRIVA|Gene=TVAG_512800|UniProtKB=A2HNG1	Actin (Fragment)	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P06587	Nicotine pharmacodynamics pathway	P06592	CHRNA6	PANTR|Ensembl=ENSPTRG00000020210|UniProtKB=Q5IS76	Neuronal acetylcholine receptor subunit alpha-6	ISS	15155845	PubMed	PTHR18945:SF82	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-6
P00035	Interferon-gamma signaling pathway	P00956	SOCS	CANLF|Ensembl=ENSCAFG00000015004|UniProtKB=E2RGD0	Uncharacterized protein	ISS	10500304	PubMed	PTHR44282:SF2	SUPPRESSOR OF CYTOKINE SIGNALING 4
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01153	GSK3	DROME|FlyBase=FBgn0028410|UniProtKB=Q9VK37	Pk34A	ISS			PTHR24056:SF7	PK34A
P05918	p38 MAPK pathway	P06018	MNK1	BOVIN|Gene=MKNK1|UniProtKB=Q58D94	MAP kinase-interacting serine/threonine-protein kinase 1	ISS	11575158	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	TAKRU|Ensembl=ENSTRUG00000002793|UniProtKB=H2S271	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF676	MYOSIN, HEAVY POLYPEPTIDE 2, FAST MUSCLE SPECIFIC
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00056	VEGF signaling pathway	P01411	Ras	DANRE|ZFIN=ZDB-GENE-040808-67|UniProtKB=Q6AZA4	K-ras	ISS	20362513	PubMed	PTHR24070:SF186	GTPASE KRAS
P00045	Notch signaling pathway	P01110	Presenilin	HUMAN|HGNC=9508|UniProtKB=P49768	Presenilin-1	IDA	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00006	Apoptosis signaling pathway	P00283	A1	MOUSE|MGI=MGI=1278325|UniProtKB=O55179	A1-d protein	IGI	11964303	PubMed	PTHR11256:SF10	BCL-2-RELATED PROTEIN A1
P00056	VEGF signaling pathway	P01417	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00010	B cell activation	P00398	IP3R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01175	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00059	p53 pathway	P01486	Akt	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	TAS	7876156	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	DICDI|dictyBase=DDB_G0274575|UniProtKB=Q9XXV8	Myosin-K heavy chain	IC			PTHR13140:SF674	MYOSIN IB HEAVY CHAIN-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00887	IRS 1-4	DROME|FlyBase=FBgn0024248|UniProtKB=Q9XTN2	Insulin receptor substrate 1	ISS	15175753	PubMed	PTHR10614:SF13	INSULIN RECEPTOR SUBSTRATE 1
P00006	Apoptosis signaling pathway	P00269	MAPK	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	ISS	20032362	PubMed	PTHR24055:SF330	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04665	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01150	PKC	BOVIN|Ensembl=ENSBTAG00000021900|UniProtKB=F1MFK1	Uncharacterized protein	ISS	11880265	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P06664	Gonadotropin-releasing hormone receptor pathway	P06852	nPKCs	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02728	Arginine biosynthesis	P02840	Argininosuccinate synthase	RAT|RGD=2163|UniProtKB=P09034	Argininosuccinate synthase	ISS			PTHR11587:SF2	ARGININOSUCCINATE SYNTHASE
P00030	Hypoxia response via HIF activation	P00819	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01098	CHT1	CANLF|Ensembl=ENSCAFG00000019243|UniProtKB=F1PZI9	Transporter	ISS			PTHR11616:SF96	SODIUM- AND CHLORIDE-DEPENDENT CREATINE TRANSPORTER 1
P00036	Interleukin signaling pathway	P00964	p90RSK	RAT|RGD=620676|UniProtKB=F1M7N7	Ribosomal protein S6 kinase	ISS	15526037	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P02738	De novo purine biosynthesis	P02899	GMP synthase	DROME|FlyBase=FBgn0000239|UniProtKB=Q9VIE7	Burgundy, isoform B	ISS			PTHR11922:SF2	GMP SYNTHASE  GLUTAMINE-HYDROLYZING
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	ARATH|TAIR=AT2G29900|UniProtKB=Q9SIK7	Presenilin-like protein At2g29900	TAS	8755489	PubMed	PTHR10202:SF22	SUBFAMILY NOT NAMED
P05917	Opioid proopiomelanocortin pathway	P06006	beta-Endorphin	BOVIN|Ensembl=ENSBTAG00000007897|UniProtKB=P01190	Pro-opiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00049	Parkinson disease	P01208	Hsp70	PSEAE|EnsemblGenome=PA4761|UniProtKB=Q9HV43	Chaperone protein DnaK	IDA	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P02723	Adenine and hypoxanthine salvage pathway	P02809	Xanthine dehydrogenase	STRCO|Gene=CAD30957|UniProtKB=Q9EWG8	Putative dehydrogenase	ISS			PTHR11908:SF121	SUBFAMILY NOT NAMED
P00012	Cadherin signaling pathway	P00474	Wnt	MACMU|Ensembl=ENSMMUG00000007765|UniProtKB=F7CW57	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00011	Blood coagulation	P00415	Plasmin	MACMU|Gene=PLG|UniProtKB=P12545	Plasminogen	ISS	130317	gi	PTHR24261:SF6	PLASMINOGEN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	DANRE|ZFIN=ZDB-GENE-051202-2|UniProtKB=Q6ZM67	Uncharacterized protein	ISS	92049750	PubMed	PTHR44391:SF3	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=69279|UniProtKB=Q9R0T4	Cadherin-1	IDA	12834808	PubMed	PTHR24027:SF319	CADHERIN-1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	ANOGA|EnsemblGenome=AGAP001394|UniProtKB=F5HMS4	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01162	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00225	MEK	MOUSE|MGI=MGI=1354946|UniProtKB=Q61532	Mitogen-activated protein kinase 6	ISS			PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00021	FGF signaling pathway	P00642	MEK1-2	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	MOUSE|MGI=MGI=109482|UniProtKB=P97445	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	14624853	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	TAS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00007	Axon guidance mediated by semaphorins	P00339	CRMP	HUMAN|HGNC=3013|UniProtKB=Q14117	Dihydropyrimidinase	ISS			PTHR11647:SF50	DIHYDROPYRIMIDINASE
P00036	Interleukin signaling pathway	P00964	p90RSK	MOUSE|MGI=MGI=1342290|UniProtKB=Q9WUT3	Ribosomal protein S6 kinase alpha-2	ISS	15526037	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P02775	Salvage pyrimidine ribonucleotides	P03150	Uridine kinase	ARATH|TAIR=AT1G73980|UniProtKB=Q9C9B9	At1g73980/F2P9_15	ISS			PTHR10285:SF122	URIDINE-CYTIDINE KINASE C
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	IC	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P06959	CCKR signaling map	P07218	FAK2	HUMAN|HGNC=9612|UniProtKB=Q14289	Protein-tyrosine kinase 2-beta	RCA	21810446	PubMed	PTHR24418:SF94	PROTEIN-TYROSINE KINASE 2-BETA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEEL|WormBase=WBGene00018620|UniProtKB=O44588	Uncharacterized protein	ISS	2837282	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00059	p53 pathway	P04623	CBP	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	IDA	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04398	p53 pathway feedback loops 2	P04665	AKT	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	22081553	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01185	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00012	Cadherin signaling pathway	P00475	Frizzled	HUMAN|HGNC=4038|UniProtKB=Q9UP38	Frizzled-1	IDA	11212302	PubMed	PTHR11309:SF81	FRIZZLED-1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	TAS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00047	PDGF signaling pathway	P01142	p90RSK	MOUSE|MGI=MGI=1270849|UniProtKB=Q8BSK8	Ribosomal protein S6 kinase beta-1	ISS	15116068	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00010	B cell activation	P00402	Jnk	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00034	Integrin signalling pathway	P00938	Cdc42	HUMAN|HGNC=1736|UniProtKB=P60953	Cell division control protein 42 homolog	IDA	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00059	p53 pathway	P01486	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02723	Adenine and hypoxanthine salvage pathway	P02809	Xanthine dehydrogenase	PANTR|Ensembl=ENSPTRG00000011806|UniProtKB=H2QHQ2	Uncharacterized protein	ISS	12969896	PubMed	PTHR11908:SF80	XANTHINE DEHYDROGENASE/OXIDASE
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	MACMU|Ensembl=ENSMMUG00000000893|UniProtKB=F6T7D0	Histone acetyltransferase p300	ISS	10769018	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00005	Angiogenesis	P00227	PLA2	PANTR|Ensembl=ENSPTRG00000001787|UniProtKB=H2Q0T0	Phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P05913	Enkephalin release	P05972	PKA	MOUSE|MGI=MGI=1309999|UniProtKB=Q922R0	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00017	DNA replication	P00536	DNA Topisomerase	MACMU|Ensembl=ENSMMUG00000007371|UniProtKB=F7E5A9	DNA topoisomerase 2	ISS			PTHR10169:SF36	DNA TOPOISOMERASE 2-BETA
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DICDI|dictyBase=DDB_G0289489|UniProtKB=P07828	Actin-18	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00010	B cell activation	P00384	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04398	p53 pathway feedback loops 2	P04657	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	ANOGA|EnsemblGenome=AGAP000763|UniProtKB=Q7QE97	Serine/threonine-protein kinase receptor	TAS	9395284	PubMed	PTHR23255:SF70	SERINE/THREONINE-PROTEIN KINASE RECEPTOR
P00024	Glycolysis	P00678	Enolase	RAT|RGD=2554|UniProtKB=P07323	Gamma-enolase	ISS	5803011	gi	PTHR11902:SF10	GAMMA-ENOLASE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00049	Parkinson disease	P01227	20S proteasome	DICDI|dictyBase=DDB_G0280969|UniProtKB=P34119	Proteasome subunit alpha type-4	TAS	12859888	PubMed	PTHR11599:SF13	PROTEASOME SUBUNIT ALPHA TYPE-4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	DROME|FlyBase=FBgn0010269|UniProtKB=Q24324	Dual specificity mitogen-activated protein kinase kinase dSOR1	IC	176872	OMIM	PTHR24361:SF629	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	RAT|RGD=68384|UniProtKB=P39948	G1/S-specific cyclin-D1	IEP	93330551	PubMed	PTHR10177:SF67	G1/S-SPECIFIC CYCLIN-D1
P02766	Phenylethylamine degradation	P03103	Phenylethylamine oxidase	BOVIN|Gene=AOC3|UniProtKB=Q9TTK6	Membrane primary amine oxidase	ISS			PTHR10638:SF23	MEMBRANE PRIMARY AMINE OXIDASE
P00018	EGF receptor signaling pathway	P00555	MKK4,7	DROME|FlyBase=FBgn0024326|UniProtKB=O61444	MAP kinase kinase 4, isoform A	NAS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000002245|UniProtKB=H2RYC6	Uncharacterized protein (Fragment)	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P05731	GABA-B receptor II signaling	P05755	Gbeta	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	RAT|RGD=628852|UniProtKB=Q02294	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	14507926	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00021	FGF signaling pathway	P00627	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	13430383	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00030	Hypoxia response via HIF activation	P00824	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	TAS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00057	Wnt signaling pathway	P01464	Pygo	BOVIN|Ensembl=ENSBTAG00000009151|UniProtKB=F1MHP8	Uncharacterized protein	ISS	11955446	PubMed	PTHR23194:SF3	PYGOPUS HOMOLOG 1
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	HUMAN|HGNC=10935|UniProtKB=Q05940	Synaptic vesicular amine transporter	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=1858235|UniProtKB=Q9R0M0	Cadherin EGF LAG seven-pass G-type receptor 2	IDA	8120095	PubMed	PTHR24026:SF32	CADHERIN EGF LAG SEVEN-PASS G-TYPE RECEPTOR 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=3023|UniProtKB=P14416	D(2) dopamine receptor	IDA	2137198	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TRIAD|EnsemblGenome=TriadG56111|UniProtKB=B3RX77	Non-muscle actin 6.2	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	MONDO|Ensembl=ENSMODG00000016960|UniProtKB=F6V5G0	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00019	Endothelin signaling pathway	P00586	Gq	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00029	Huntington disease	P00807	Actin	DROME|FlyBase=FBgn0011743|UniProtKB=P45891	Actin-like protein 53D	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02728	Arginine biosynthesis	P02846	Ornithine carbamoyl transferase	THEMA|EnsemblGenome=TM_1097|UniProtKB=P96108	Ornithine carbamoyltransferase	ISS			PTHR11405:SF44	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00577	PI3K	XENTR|Xenbase=XB-GENE-6067221|UniProtKB=F6Z0J4	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	MOUSE|MGI=MGI=88396|UniProtKB=P12657	Muscarinic acetylcholine receptor M1	ISS	8100450	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00006	Apoptosis signaling pathway	P00306	TRAF2	HUMAN|HGNC=12032|UniProtKB=Q12933	TNF receptor-associated factor 2	IDA	8069916	PubMed	PTHR10131:SF21	TNF RECEPTOR-ASSOCIATED FACTOR 2
P00021	FGF signaling pathway	P00632	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04651	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	RAT|RGD=2246|UniProtKB=Q07652	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	8386525	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00048	PI3 kinase pathway	P01196	PDK1	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	9094314	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	RAT|RGD=2735|UniProtKB=Q63273	Glutamate receptor ionotropic, kainate 5	ISS	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	BOVIN|Ensembl=ENSBTAG00000014674|UniProtKB=P41985	Muscarinic acetylcholine receptor M2	ISS	11166329	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00057	Wnt signaling pathway	P01465	Ggamma	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CAEEL|WormBase=WBGene00009730|UniProtKB=O62244	MYOsin heavy chain structural genes	IC			PTHR13140:SF302	MYOSIN HEAVY CHAIN STRUCTURAL GENES
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00019	Endothelin signaling pathway	P00566	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01226	CDCrel-1	PANTR|Ensembl=ENSPTRG00000007998|UniProtKB=H2QAX3	Uncharacterized protein	ISS			PTHR18884:SF6	SEPTIN-1
P00036	Interleukin signaling pathway	P00965	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	IC	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00045	Notch signaling pathway	P01119	NIct	MACMU|Ensembl=ENSMMUG00000017022|UniProtKB=F7HQZ9	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00848	Grb	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	4504111	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00046	Oxidative stress response	P01129	JNK1/2	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05916	Opioid prodynorphin pathway	P06002	G-protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	ISS	8170357	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00010	B cell activation	P00373	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	P01444	Wnt	RAT|RGD=621346|UniProtKB=Q2IBD1	Protein Wnt	IDA	11266476	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00034	Integrin signalling pathway	P00906	Rap1	MACMU|Ensembl=ENSMMUG00000011442|UniProtKB=F7B9T3	Ras-related protein Rap-1b	ISS	10476970	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00049	Parkinson disease	P01207	PLD2	PANTR|Ensembl=ENSPTRG00000008610|UniProtKB=H2QBY9	Uncharacterized protein	ISS	15030398	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	MOUSE|MGI=MGI=102891|UniProtKB=P51829	Adenylate cyclase type 7	IC	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00034	Integrin signalling pathway	P00942	Fyn	MOUSE|MGI=MGI=95602|UniProtKB=P39688	Tyrosine-protein kinase Fyn	IPI	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00053	T cell activation	P01332	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00057	Wnt signaling pathway	P01444	Wnt	MACMU|Ensembl=ENSMMUG00000022937|UniProtKB=F6U717	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P02772	Pyruvate metabolism	P03132	Pyruvate Kinase	PANTR|Ensembl=ENSPTRG00000007246|UniProtKB=H2Q9R0	Pyruvate kinase	ISS	8193145	PubMed	PTHR11817:SF23	SUBFAMILY NOT NAMED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHICK|Ensembl=ENSGALG00000009844|UniProtKB=P68034	Actin, alpha cardiac muscle 1	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P02738	De novo purine biosynthesis	P02889	dGDP kinase	PANTR|Ensembl=ENSPTRG00000009415|UniProtKB=H2QDG2	Nucleoside diphosphate kinase	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	MOUSE|MGI=MGI=99474|UniProtKB=Q91YI4	Beta-arrestin-2	ISS	11742073	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00048	PI3 kinase pathway	P01196	PDK1	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	IDA	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	DAPPU|EnsemblGenome=DAPPUDRAFT_206575|UniProtKB=E9FUX0	Guanine nucleotide binding protein, beta subunit	ISS	9740024	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04398	p53 pathway feedback loops 2	P04665	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00566	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00566	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00375	Calmodulin	CANLF|Ensembl=ENSCAFG00000016335|UniProtKB=J9NXY2	Uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF322	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00932	FAK	RAT|RGD=3443|UniProtKB=O35346	Focal adhesion kinase 1	IPI	9182576	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	CANLF|Ensembl=ENSCAFG00000017522|UniProtKB=Q076A4	Myosin-8	ISS	10938134	PubMed	PTHR13140:SF368	MYOSIN-8
P00005	Angiogenesis	P00233	CSL	HUMAN|HGNC=5724|UniProtKB=Q06330	Recombining binding protein suppressor of hairless	IDA	15187023	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00021	FGF signaling pathway	P00632	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MOUSE|MGI=MGI=1927469|UniProtKB=Q9QZB0	Regulator of G-protein signaling 17	IDA	21240406	PubMed	PTHR10845:SF196	REGULATOR OF G-PROTEIN SIGNALING 17
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00010	B cell activation	P00383	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	BOVIN|Ensembl=ENSBTAG00000007882|UniProtKB=G3X7Z2	Uncharacterized protein	ISS	8386525	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00037	Ionotropic glutamate receptor pathway	P01020	NSF	MONDO|Ensembl=ENSMODG00000011031|UniProtKB=F7F4B9	Uncharacterized protein	ISS	601633	OMIM	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00053	T cell activation	P01318	PKC-theta	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00012	Cadherin signaling pathway	P00474	Wnt	DANRE|ZFIN=ZDB-GENE-980526-249|UniProtKB=Q9I9I2	Protein Wnt	IDA	8717036	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00014	Cholesterol biosynthesis	P00492	Mevalonate kinase	MACMU|Ensembl=ENSMMUG00000011663|UniProtKB=F7HGV8	Uncharacterized protein	ISS	9392419	PubMed	PTHR43290:SF2	MEVALONATE KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	TAS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00029	Huntington disease	P00811	Arp2/3 complex	MONDO|Ensembl=ENSMODG00000001303|UniProtKB=F7BZM9	Uncharacterized protein (Fragment)	ISS	12473693	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00053	T cell activation	P01332	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	CAEEL|WormBase=WBGene00009119|UniProtKB=Q93576	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DICDI|dictyBase=DDB_G0279605|UniProtKB=P34148	Rho-related protein racB	ISS	4757952	gi	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P05916	Opioid prodynorphin pathway	P06002	G-protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	ISS	15860573	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	NEUCR|EnsemblGenome=EFNCRG00000004240|UniProtKB=Q01386	cAMP-dependent protein kinase regulatory subunit	ISS	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	DROME|FlyBase=FBgn0001991|UniProtKB=Q24270	Voltage-dependent calcium channel type D subunit alpha-1	ISS	91056091	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	CAEBR|Gene=CBG14305|UniProtKB=A8XJQ6	cAMP-dependent protein kinase, catalytic subunit-like	ISS	1319556	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05913	Enkephalin release	P05974	G-Protein (i)	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	IC	15860573	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00034	Integrin signalling pathway	P00944	Actin	MONDO|Ensembl=ENSMODG00000023202|UniProtKB=F7EU36	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01413	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	14505573	PubMed	PTHR10048:SF14	PI-3 KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	BOVIN|Gene=CACNB1|UniProtKB=Q9MZL7	Voltage-dependent L-type calcium channel subunit beta-1	IC	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00852	PYK2	MACMU|Ensembl=ENSMMUG00000019159|UniProtKB=F6SS49	Uncharacterized protein	ISS	10753828	PubMed	PTHR24418:SF94	PROTEIN-TYROSINE KINASE 2-BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00586	Gq	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00018	EGF receptor signaling pathway	P00547	PP2A	ARATH|TAIR=AT3G21650|UniProtKB=Q9LVE2	Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' zeta isoform	ISS			PTHR10257:SF27	SERINE/THREONINE PROTEIN PHOSPHATASE 2A 59 KDA REGULATORY SUBUNIT B' GAMMA ISOFORM-RELATED
P00021	FGF signaling pathway	P00627	ERK1-2	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P02734	Chorismate biosynthesis	P02870	3-Phosphoshikimate-1-carboxyvinyl transferase	BACTN|EnsemblGenome=BT_2186|UniProtKB=Q8A5Q2	3-phosphoshikimate 1-carboxyvinyltransferase	ISS			PTHR21090:SF5	PENTAFUNCTIONAL AROM POLYPEPTIDE
P04393	Ras Pathway	P04570	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00570	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00269	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05913	Enkephalin release	P05974	G-Protein (i)	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	BOVIN|Ensembl=ENSBTAG00000013885|UniProtKB=A7MBG0	Adenylosuccinate synthetase isozyme 2	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P06664	Gonadotropin-releasing hormone receptor pathway	P06805	MKK3/6	MOUSE|MGI=MGI=1346868|UniProtKB=O09110	Dual specificity mitogen-activated protein kinase kinase 3	RCA	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04393	Ras Pathway	P04559	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12912997	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00019	Endothelin signaling pathway	P00589	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00053	T cell activation	P01332	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MONDO|Ensembl=ENSMODG00000004799|UniProtKB=F6VM87	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00006	Apoptosis signaling pathway	P00291	MEKK1	RAT|RGD=620966|UniProtKB=Q62925	Mitogen-activated protein kinase kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00047	PDGF signaling pathway	P01151	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00916	Ras	BOVIN|Ensembl=ENSBTAG00000009778|UniProtKB=E1BMX0	Uncharacterized protein	ISS	9869449	PubMed	PTHR24070:SF186	GTPASE KRAS
P00047	PDGF signaling pathway	P01154	Ras	DANRE|ZFIN=ZDB-GENE-990415-166|UniProtKB=P79737	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00846	JAK	PANTR|Ensembl=ENSPTRG00000020744|UniProtKB=H2QWZ4	Tyrosine-protein kinase	ISS	22482294	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01443	Phospholipase C	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00010	B cell activation	P00383	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IDA	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00898	FKHR	BOVIN|Ensembl=ENSBTAG00000011234|UniProtKB=F1N4K5	Uncharacterized protein	ISS	10102273	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00019	Endothelin signaling pathway	P00566	ERK	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	IGI	12787066	PubMed	PTHR24055:SF330	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00591	PLCbeta	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MACMU|Ensembl=ENSMMUG00000023785|UniProtKB=F7HTD6	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P02770	Pyridoxal phosphate salvage pathway	P03122	Pyridoxamine kinase	PANTR|Ensembl=ENSPTRG00000040962|UniProtKB=H2RGH3	Pyridoxal (Pyridoxine, vitamin B6) kinase	ISS	9099727	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IDA	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00030	Hypoxia response via HIF activation	P00819	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04665	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00059	p53 pathway	P04633	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	ANOGA|EnsemblGenome=AGAP005911|UniProtKB=Q7Q6D4	AGAP005911-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00036	Interleukin signaling pathway	P00965	ERK	CHICK|Ensembl=ENSGALG00000004690|UniProtKB=Q5F3W3	Mitogen-activated protein kinase 6	ISS	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00005	Angiogenesis	P00245	Rac	CAEBR|Gene=CBG02886|UniProtKB=A8WTA3	Protein CBR-RGA-1	ISS			PTHR23176:SF0	RHO GTPASE-ACTIVATING PROTEIN 68F
P00004	Alzheimer disease-presenilin pathway	P00114	actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g242065|UniProtKB=A7S0V7	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MACMU|Ensembl=ENSMMUG00000010392|UniProtKB=F7ASR8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00005	Angiogenesis	P00244	MAPKAPK2/3	BOVIN|Ensembl=ENSBTAG00000038107|UniProtKB=F1MCX5	Uncharacterized protein	ISS	9628873	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00018	EGF receptor signaling pathway	P00559	MEK1-2	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05916	Opioid prodynorphin pathway	G06049	preprodynorphin	PANTR|Ensembl=ENSPTRG00000013172|UniProtKB=H2QJT9	Uncharacterized protein	ISS	131330	OMIM	PTHR11438:SF4	PROENKEPHALIN-B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00053	T cell activation	P01333	cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	RCA	11035810	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00053	T cell activation	P01332	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IDA	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01306	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00049	Parkinson disease	P01208	Hsp70	SYNY3|EnsemblGenome=BAA10290|UniProtKB=Q55154	Chaperone protein dnaK1	ISS	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CHICK|Ensembl=ENSGALG00000014620|UniProtKB=F1N8P3	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	PANTR|Ensembl=ENSPTRG00000017414|UniProtKB=H2QRT0	Uncharacterized protein	ISS	10092204	PubMed	PTHR43940:SF5	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	TAKRU|Ensembl=ENSTRUG00000018612|UniProtKB=H2VEM3	Protein-serine/threonine kinase	RCA			PTHR24355:SF18	PROTEIN-SERINE/THREONINE KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	PANTR|Ensembl=ENSPTRG00000013825|UniProtKB=H2RAK4	Uncharacterized protein	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00809	Caspase 6	XENTR|Xenbase=XB-GENE-482797|UniProtKB=F6R1R1	Uncharacterized protein	ISS	10770929	PubMed	PTHR10454:SF164	CASPASE-6
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	HUMAN|HGNC=3814|UniProtKB=O75593	Forkhead box protein H1	IGI	9288972	PubMed	PTHR11829:SF191	FORKHEAD BOX PROTEIN H1
P00018	EGF receptor signaling pathway	P00551	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00054	Toll receptor signaling pathway	P01381	Ubc13	MONDO|Ensembl=ENSMODG00000023075|UniProtKB=F7G1G8	Uncharacterized protein	ISS			PTHR43902:SF2	UBIQUITIN-CONJUGATING ENZYME E2 N
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	CANLF|Ensembl=ENSCAFG00000005204|UniProtKB=B6V8E6	Catenin beta-1	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00021	FGF signaling pathway	P00646	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	IPI	88318957	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	ORNAN|Ensembl=ENSOANG00000015652|UniProtKB=F7FY70	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P02749	Leucine biosynthesis	P03002	Isopropylmalate isomerase	PYRAE|EnsemblGenome=PAE1984|UniProtKB=Q8ZW41	3-isopropylmalate dehydratase large subunit	ISS			PTHR43822:SF4	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00990	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04393	Ras Pathway	P04557	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00010	B cell activation	P00373	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IGI	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00004	Alzheimer disease-presenilin pathway	P00141	Membrane metalloprotease	HUMAN|HGNC=7162|UniProtKB=P51512	Matrix metalloproteinase-16	RCA			PTHR10201:SF26	MATRIX METALLOPROTEINASE-16
P00052	TGF-beta signaling pathway	P01284	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	15621031	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	MACMU|Ensembl=ENSMMUG00000000293|UniProtKB=F6YFG3	Uncharacterized protein	ISS	1638632	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P00019	Endothelin signaling pathway	P00566	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	BOVIN|Ensembl=ENSBTAG00000011851|UniProtKB=A0JNB0	Tyrosine-protein kinase Fyn	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CAEEL|WormBase=WBGene00006538|UniProtKB=P41937	Tubulin beta-4 chain	ISS	9454836	PubMed	PTHR11588:SF89	TUBULIN BETA-4 CHAIN
P06664	Gonadotropin-releasing hormone receptor pathway	P06753	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	RCA	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00036	Interleukin signaling pathway	P00983	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00572	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000010521|UniProtKB=F7DQK7	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02779	Thiamin biosynthesis	P03170	Hydroxymethylpyrimidine phosphate kinase	BACTN|EnsemblGenome=BT_0790|UniProtKB=Q8A9M5	Phosphomethylpyrimidine kinase	ISS			PTHR20858:SF17	HYDROXYMETHYLPYRIMIDINE/PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	IC	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	TAS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	HUMAN|HGNC=3020|UniProtKB=P21728	D(1A) dopamine receptor	ISS	11861492	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00019	Endothelin signaling pathway	P00586	Gq	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IDA	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00551	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00017	DNA replication	P00527	Histones	ARATH|TAIR=AT1G09200|UniProtKB=P59226	Histone H3.2	ISS	12413958	PubMed	PTHR11426:SF172	HISTONE H3-LIKE 5-RELATED
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05734	Synaptic vesicle trafficking	P05774	NSF	MACMU|Ensembl=ENSMMUG00000005548|UniProtKB=F6YT14	Uncharacterized protein	ISS	7969419	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00047	PDGF signaling pathway	P01142	p90RSK	MOUSE|MGI=MGI=2443413|UniProtKB=Q8R2S1	Ribosomal protein S6 kinase-like 1	ISS			PTHR15508:SF4	RIBOSOMAL PROTEIN S6 KINASE-LIKE 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	DROME|FlyBase=FBgn0019947|UniProtKB=O02194	Presenilin homolog	TAS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MOUSE|MGI=MGI=1859709|UniProtKB=P97492	Regulator of G-protein signaling 14	IDA	10779778	PubMed	PTHR10845:SF179	REGULATOR OF G-PROTEIN SIGNALING 14
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	MOUSE|MGI=MGI=1351341|UniProtKB=Q68EF4	Metabotropic glutamate receptor 4	IC	9407094	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000010591|UniProtKB=H2R6B7	Uncharacterized protein	ISS	10644715	PubMed	PTHR24356:SF246	SERINE/THREONINE-PROTEIN KINASE N1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00018	EGF receptor signaling pathway	P00547	PP2A	BOVIN|Ensembl=ENSBTAG00000000469|UniProtKB=P67774	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00007	Axon guidance mediated by semaphorins	P00339	CRMP	RAT|RGD=68376|UniProtKB=Q63150	Dihydropyrimidinase	ISS			PTHR11647:SF50	DIHYDROPYRIMIDINASE
P05912	Dopamine receptor mediated signaling pathway	P05960	VAT2	MOUSE|MGI=MGI=106677|UniProtKB=Q8BRU6	Synaptic vesicular amine transporter	IC	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00023	General transcription regulation	P00666	TFIIE	MONDO|Ensembl=ENSMODG00000019005|UniProtKB=F7CP70	Transcription initiation factor IIE subunit beta	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	CHICK|Ensembl=ENSGALG00000005088|UniProtKB=E1BZ86	Uncharacterized protein	ISS	12888804	PubMed	PTHR43940:SF7	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT GAMMA
P00005	Angiogenesis	P00203	Erk	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	DICPU|Gene=DICPUDRAFT_93216|UniProtKB=F1A421	Guanine nucleotide-binding protein subunit beta	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00029	Huntington disease	P00778	NMDA receptor	CHICK|Ensembl=ENSGALG00000011809|UniProtKB=F1NMB0	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P06213	DPP signaling pathway	P06287	TSG	DROME|FlyBase=FBgn0003865|UniProtKB=P54356	Protein twisted gastrulation	IDA	11260716	PubMed	PTHR12312:SF16	TWISTED GASTRULATION PROTEIN HOMOLOG 1-A-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	HUMAN|HGNC=130|UniProtKB=P62736	Actin, aortic smooth muscle	IC	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00541	Spry	RAT|RGD=1311472|UniProtKB=Q5HZA2	Protein Spry2	ISS	12815057	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00053	T cell activation	P01294	NFAT	RAT|RGD=1310749|UniProtKB=D3Z9H7	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	ISS	9462517	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00034	Integrin signalling pathway	P00922	Collagen	HUMAN|HGNC=2209|UniProtKB=P20908	Collagen alpha-1(V) chain	IDA	10778855	PubMed	PTHR24023:SF387	COLLAGEN ALPHA-1 V  CHAIN
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	SCHPO|PomBase=SPAC16E8.16|UniProtKB=O13749	Transcription initiation factor IIB	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	TAS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02755	Methylmalonyl pathway	P03034	Methylmalonyl-CoA mutase	SULSO|EnsemblGenome=SSO2266|UniProtKB=Q97WF7	Methylmalonyl-CoA mutase, alpha-subunit, chain B (McmA2)	ISS			PTHR23408:SF19	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00572	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IGI	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00047	PDGF signaling pathway	P01171	PLCgamma	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=97614|UniProtKB=Q8R3B1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	10934033	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	MONDO|Ensembl=ENSMODG00000018065|UniProtKB=F7G485	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00005	Angiogenesis	P00221	JNK1	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04398	p53 pathway feedback loops 2	P04665	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01438	PP2A	DANRE|ZFIN=ZDB-GENE-040426-877|UniProtKB=F1Q6Z7	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	MACMU|Ensembl=ENSMMUG00000010184|UniProtKB=F6SR09	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	IDA	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00036	Interleukin signaling pathway	P00983	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P06959	CCKR signaling map	G06976	REG1A	HUMAN|HGNC=9951|UniProtKB=P05451	Lithostathine-1-alpha	RCA	9834276	PubMed	PTHR43993:SF7	LITHOSTATHINE-1-ALPHA
P06959	CCKR signaling map	G06979	MYC	HUMAN|HGNC=7553|UniProtKB=P01106	Myc proto-oncogene protein	RCA	18515095	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P04398	p53 pathway feedback loops 2	G04714	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	PANTR|Ensembl=ENSPTRG00000014976|UniProtKB=H2R892	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00010	B cell activation	P00391	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01165	SRF	MACMU|Ensembl=ENSMMUG00000000033|UniProtKB=F7G4D2	Uncharacterized protein	ISS	15326221	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00054	Toll receptor signaling pathway	P01346	TLR	MACMU|Ensembl=ENSMMUG00000002418|UniProtKB=F6PP64	Toll-like receptor	ISS			PTHR24365:SF422	TOLL-LIKE RECEPTOR 6
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00059	p53 pathway	P04633	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01221	Torsin A	MOUSE|MGI=MGI=1353568|UniProtKB=Q9ER39	Torsin-1A	ISS	12421356	PubMed	PTHR10760:SF15	TORSIN-1A
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	SCHPO|PomBase=SPAC15E1.04|UniProtKB=Q9UTI7	Probable thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00053	T cell activation	P01311	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IDA	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00623	FGF	HUMAN|HGNC=3686|UniProtKB=P55075	Fibroblast growth factor 8	IGI	12778074	PubMed	PTHR11486:SF3	FIBROBLAST GROWTH FACTOR 8
P06664	Gonadotropin-releasing hormone receptor pathway	P06786	ERK1/2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	RCA	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00920	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	STRPU|EnsemblGenome=SPU_026078|UniProtKB=W4ZD41	Uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF277	SUBFAMILY NOT NAMED
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00799	JNK-2	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00057	Wnt signaling pathway	P01438	PP2A	STRPU|EnsemblGenome=SPU_025182|UniProtKB=W4ZAK5	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	TAS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04395	Vasopressin synthesis	P04589	Signal Peptidase	RAT|RGD=1311253|UniProtKB=D3ZD11	Protein Spcs2	ISS	7788527	PubMed	PTHR13085:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 2
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	RAT|RGD=621060|UniProtKB=O88777	Presenilin-2	TAS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P05731	GABA-B receptor II signaling	P05755	Gbeta	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00053	T cell activation	P01298	NFkappaB	PANTR|Ensembl=ENSPTRG00000016320|UniProtKB=H2QPY8	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	ISS	12574369	PubMed	PTHR24169:SF9	NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	XENTR|Xenbase=XB-GENE-481916|UniProtKB=F6YF14	Presenilin	ISS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	BOVIN|Ensembl=ENSBTAG00000001575|UniProtKB=F1N6C0	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF311	CALMODULIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IDA	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00833	RGS	MONDO|Ensembl=ENSMODG00000008463|UniProtKB=F7GET1	Uncharacterized protein	ISS	21240406	PubMed	PTHR10845:SF196	REGULATOR OF G-PROTEIN SIGNALING 17
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	SCHMA|EnsemblGenome=Smp_183710|UniProtKB=G4VLW1	Putative actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MOUSE|MGI=MGI=99674|UniProtKB=Q91WF3	Adenylate cyclase type 4	IGI	2491850	PubMed	PTHR11920:SF286	ADENYLATE CYCLASE TYPE 4
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	DANRE|ZFIN=ZDB-GENE-030513-3|UniProtKB=B3DJU0	Thyroid stimulating hormone, beta subunit	ISS	3017658	PubMed	PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04393	Ras Pathway	P04547	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	HUMAN|HGNC=6266|UniProtKB=P48544	G protein-activated inward rectifier potassium channel 4	ISS	2433589	PubMed	PTHR11767:SF52	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 4
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P02731	Biotin biosynthesis	P02857	Biotin synthase	BACSU|EnsemblGenome=BSU30200|UniProtKB=P53557	Biotin synthase	ISS			PTHR22976:SF1	BIOTIN SYNTHASE, MITOCHONDRIAL
P00007	Axon guidance mediated by semaphorins	P00339	CRMP	PANTR|Ensembl=ENSPTRG00000003073|UniProtKB=H2Q2S9	Dihydropyrimidinase-like 4	ISS			PTHR11647:SF55	DIHYDROPYRIMIDINASE-RELATED PROTEIN 4
P04392	P53 pathway feedback loops 1	P04538	Pirh-2	MACMU|Ensembl=ENSMMUG00000009177|UniProtKB=F7HPB9	RING finger and CHY zinc finger domain-containing protein 1	ISS	607680	OMIM	PTHR21319:SF20	RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00059	p53 pathway	G04694	p110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	RAT|RGD=1309318|UniProtKB=D4A3N4	Adenylate cyclase 1 (Predicted)	ISS	89298382	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P00053	T cell activation	P01294	NFAT	MACMU|Ensembl=ENSMMUG00000003370|UniProtKB=F7E8G2	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	RAT|RGD=2026|UniProtKB=P68035	Actin, alpha cardiac muscle 1	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00036	Interleukin signaling pathway	P00983	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IC	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01413	PI3K	DROME|FlyBase=FBgn0015278|UniProtKB=Q7K3H0	LD28067p	ISS	14526383	PubMed	PTHR10048:SF64	LD28067P
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	ORNAN|Ensembl=ENSOANG00000002061|UniProtKB=F7ANC6	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	TAS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01275	P38	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	TAS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	IDA	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P02776	Serine glycine biosynthesis	P03160	Phosphoglycerate dehydrogenase	SULSO|EnsemblGenome=SSO3187|UniProtKB=Q97U35	D-3-phosphoglycerate dehydrogenase, putative (SerA-2)	ISS			PTHR10996:SF203	2-HYDROXYACID DEHYDROGENASE YGL185C-RELATED
P00019	Endothelin signaling pathway	P00586	Gq	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00019	Endothelin signaling pathway	P00586	Gq	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00006	Apoptosis signaling pathway	P00269	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00036	Interleukin signaling pathway	P00981	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00021	FGF signaling pathway	P00637	MKK4,7	BOVIN|Ensembl=ENSBTAG00000012103|UniProtKB=A5PJP8	MAP2K4 protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	BOVIN|Ensembl=ENSBTAG00000014600|UniProtKB=E1BQ12	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00021	FGF signaling pathway	P00643	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	BOVIN|Gene=TAF7|UniProtKB=Q2HJG8	Transcription initiation factor TFIID subunit 7	ISS			PTHR12228:SF6	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 7
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000017612|UniProtKB=C7G3N0	Glutamate receptor, metabotropic 6	ISS	12488551	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00049	Parkinson disease	P01211	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	BOVIN|Ensembl=ENSBTAG00000018576|UniProtKB=A8E641	DPYSL5 protein	ISS	11034345	PubMed	PTHR11647:SF58	DIHYDROPYRIMIDINASE-RELATED PROTEIN 5
P00057	Wnt signaling pathway	P01444	Wnt	CAEBR|Gene=CBG03422|UniProtKB=A8WV10	Protein CBR-CWN-2	ISS	11266476	PubMed	PTHR12027:SF77	PROTEIN WNT-5
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MONDO|Ensembl=ENSMODG00000024011|UniProtKB=F7CGM4	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00053	T cell activation	P01322	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00029	Huntington disease	P00775	Rac	BOVIN|Ensembl=ENSBTAG00000000347|UniProtKB=Q1RMI2	Ras homolog gene family, member G (Rho G)	ISS	12932731	PubMed	PTHR24072:SF158	RHO-RELATED GTP-BINDING PROTEIN RHOG
P06664	Gonadotropin-releasing hormone receptor pathway	G06679	Nur77	MOUSE|MGI=MGI=1352454|UniProtKB=P12813	Nuclear receptor subfamily 4 group A member 1	RCA			PTHR24085:SF1	NUCLEAR RECEPTOR SUBFAMILY 4 GROUP A MEMBER 1
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	PANTR|Ensembl=ENSPTRG00000023608|UniProtKB=H2QZZ2	Uncharacterized protein	ISS	11554554	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IGI	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	IC	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04392	P53 pathway feedback loops 1	P04539	p53	HUMAN|HGNC=12003|UniProtKB=O15350	Tumor protein p73	TAS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	IC	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IDA	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00018	EGF receptor signaling pathway	P00546	GAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	IGI	2842690	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P05731	GABA-B receptor II signaling	P05752	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	IXOSC|EnsemblGenome=ISCW014549|UniProtKB=B7QGY5	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	G04700	PAI	BOVIN|Ensembl=ENSBTAG00000014465|UniProtKB=P13909	Plasminogen activator inhibitor 1	ISS	129575	gi	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05915	Opioid proenkephalin pathway	P05994	G-protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	HUMAN|HGNC=12412|UniProtKB=Q13885	Tubulin beta-2A chain	ISS	12932731	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IC	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	YEAST|SGD=S000004715|UniProtKB=Q04439	Myosin-5	IC			PTHR13140:SF663	HEAVY CHAIN, UNCONVENTIONAL MYOSIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	IDA	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00049	Parkinson disease	P01230	Src kinase	BOVIN|Ensembl=ENSBTAG00000021424|UniProtKB=Q0VBZ0	Tyrosine-protein kinase CSK	ISS	7687537	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00029	Huntington disease	P00807	Actin	PHANO|EnsemblGenome=SNOG_01139|UniProtKB=H2KNE6	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	ARATH|TAIR=AT1G79000|UniProtKB=Q9C5X9	Histone acetyltransferase HAC1	TAS	8413673	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04393	Ras Pathway	P04542	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P06664	Gonadotropin-releasing hormone receptor pathway	P06768	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	RCA	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P02746	Heme biosynthesis	P02975	Uroporphyrinogen decarboxylase	LEPIN|EnsemblGenome=LB_016|UniProtKB=Q8EY41	Uroporphyrinogen decarboxylase	ISS			PTHR21091:SF2	UROPORPHYRINOGEN DECARBOXYLASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MACMU|Ensembl=ENSMMUG00000005586|UniProtKB=F7G4I3	Ribosomal protein S6 kinase	ISS	9687510	PubMed	PTHR24351:SF115	RIBOSOMAL PROTEIN S6 KINASE ALPHA-5
P00053	T cell activation	P01325	LAT	MOUSE|MGI=MGI=1342293|UniProtKB=O54957	Linker for activation of T-cells family member 1	IPI	9489702	PubMed	PTHR15586:SF0	LINKER FOR ACTIVATION OF T-CELLS FAMILY MEMBER 1
P04393	Ras Pathway	P04572	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02738	De novo purine biosynthesis	P02901	Adenosuccinate lyase	FUSNN|EnsemblGenome=FN0368|UniProtKB=Q8RGD3	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TRIVA|Gene=TVAG_054030|UniProtKB=A2G1K5	Actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00633	Ras	CHICK|Ensembl=ENSGALG00000006885|UniProtKB=P08642	GTPase HRas	ISS	87226391	PubMed	PTHR24070:SF385	GTPASE HRAS
P00059	p53 pathway	P01480	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	TAS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=109355|UniProtKB=O35526	Syntaxin-1A	ISS	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000024992|UniProtKB=F6TUR3	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00015	Circadian clock system	P00506	BMAL1	DROME|FlyBase=FBgn0023094|UniProtKB=O61734	Protein cycle	IDA	9630224	PubMed	PTHR23042:SF99	PROTEIN CYCLE
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00920	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01095	beta	PANTR|Ensembl=ENSPTRG00000007348|UniProtKB=H2Q9W8	Uncharacterized protein	ISS	22213672	PubMed	PTHR18945:SF385	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-4
P05913	Enkephalin release	P05978	AC	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00029	Huntington disease	P00807	Actin	PHYPA|Gene=PHYPADRAFT_226658|UniProtKB=A9TYG3	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	PANTR|Ensembl=ENSPTRG00000011042|UniProtKB=H2QGF5	Uncharacterized protein	ISS	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00018	EGF receptor signaling pathway	P00565	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MACMU|Ensembl=ENSMMUG00000010987|UniProtKB=F7GCX9	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00047	PDGF signaling pathway	P01173	STAT	CAEEL|WormBase=WBGene00013111|UniProtKB=Q9NAD6	Signal transducer and activator of transcription 1	ISS			PTHR11801:SF43	SIGNAL TRANSDUCER AND TRANSCRIPTION ACTIVATOR
P00014	Cholesterol biosynthesis	P00491	Hydroxymethyl glutaryl CoA reductase	MOUSE|MGI=MGI=96159|UniProtKB=Q01237	3-hydroxy-3-methylglutaryl-coenzyme A reductase	ISS	P00347	SPACC	PTHR10572:SF2	3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DANRE|ZFIN=ZDB-GENE-030131-1229|UniProtKB=Q6DHS1	Actin, alpha 2, smooth muscle, aorta	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	XENTR|Xenbase=XB-GENE-483731|UniProtKB=Q5BL72	Frizzled-7	ISS	8717036	PubMed	PTHR11309:SF31	FRIZZLED-7
P00005	Angiogenesis	P00223	Akt	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	ISS			PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	HUMAN|HGNC=706|UniProtKB=O15145	Actin-related protein 2/3 complex subunit 3	ISS	12473693	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	ARATH|TAIR=AT5G07880|UniProtKB=Q9SD96	SNAP25 homologous protein SNAP29	IC			PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TAKRU|Ensembl=ENSTRUG00000007989|UniProtKB=P68140	Actin, alpha skeletal muscle A	IC	11889126	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05913	Enkephalin release	P05976	Enkephalin	PANTR|Ensembl=ENSPTRG00000020270|UniProtKB=H2QW70	Proenkephalin	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	IC	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00633	Ras	SCHPO|PomBase=SPAC17H9.09c|UniProtKB=P08647	Ras-like protein 1	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00053	T cell activation	P01320	PLC-gamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00059	p53 pathway	P04630	PP2A	TAKRU|Ensembl=ENSTRUG00000008018|UniProtKB=H2T5N4	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04552	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	SCHMA|EnsemblGenome=Smp_202970|UniProtKB=G4VLN1	Putative uncharacterized protein Smp_202970	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00036	Interleukin signaling pathway	P00972	MNK1/2	HUMAN|HGNC=7111|UniProtKB=Q9HBH9	MAP kinase-interacting serine/threonine-protein kinase 2	IC	9155017	PubMed	PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P00029	Huntington disease	P00795	BDNF	ORNAN|Ensembl=ENSOANG00000013030|UniProtKB=O02795	Brain-derived neurotrophic factor (Fragment)	ISS	11724916	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00056	VEGF signaling pathway	P01417	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P02743	Formyltetrahydroformate biosynthesis	P02958	Dihydrofolate synthase	ARATH|TAIR=AT3G55630|UniProtKB=Q8W035	Folylpolyglutamate synthase	ISS			PTHR11136:SF5	FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT1G53510|UniProtKB=Q9C5C0	Mitogen-activated protein kinase 18	ISS	12787066	PubMed	PTHR24055:SF200	MITOGEN-ACTIVATED PROTEIN KINASE 18-RELATED
P00019	Endothelin signaling pathway	P00566	ERK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	NAS	13430383	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00774	Dynein complex	ARATH|TAIR=AT3G16120|UniProtKB=Q9LW74	At3g16120	IPI	9454836	PubMed	PTHR11886:SF47	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04572	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IDA	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00037	Ionotropic glutamate receptor pathway	P01023	CaMKII	BOVIN|Ensembl=ENSBTAG00000014463|UniProtKB=Q2HJF7	Calcium/calmodulin-dependent protein kinase type II subunit delta	ISS	12888804	PubMed	PTHR43940:SF4	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT DELTA
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=620749|UniProtKB=Q767H7	Cadherin-related neuronal receptor c2	ISS	8120095	PubMed	PTHR24028:SF119	PROTOCADHERIN ALPHA-C2
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00273	p53	DANRE|ZFIN=ZDB-GENE-990415-270|UniProtKB=P79734	Cellular tumor antigen p53	ISS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04393	Ras Pathway	P04545	Sec5	CHICK|Ensembl=ENSGALG00000012837|UniProtKB=R4GJ00	Uncharacterized protein	ISS			PTHR13043:SF1	EXOCYST COMPLEX COMPONENT 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IDA	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00034	Integrin signalling pathway	P00910	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	8051109	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	CANLF|Ensembl=ENSCAFG00000004381|UniProtKB=J9JH96	Uncharacterized protein	ISS	92317054	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MOUSE|MGI=MGI=1929866|UniProtKB=Q9QZB1	Regulator of G-protein signaling 20	IDA	8756726	PubMed	PTHR10845:SF175	REGULATOR OF G-PROTEIN SIGNALING 20
P00047	PDGF signaling pathway	P01172	c-Myc	RAT|RGD=2320727|UniProtKB=D4A7F2	Protein Mycbp	ISS	15094771	PubMed	PTHR13168:SF0	C-MYC-BINDING PROTEIN
P00053	T cell activation	P01336	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	BOVIN|Gene=CTNNA1|UniProtKB=Q3MHM6	Catenin alpha-1	ISS	1768802	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P04398	p53 pathway feedback loops 2	P04657	P110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00060	Ubiquitin proteasome pathway	P01491	E2	HUMAN|HGNC=12476|UniProtKB=P61077	Ubiquitin-conjugating enzyme E2 D3	ISS			PTHR24068:SF48	UBIQUITIN-CONJUGATING ENZYME E2 D3
P00018	EGF receptor signaling pathway	P00547	PP2A	MOUSE|MGI=MGI=1321159|UniProtKB=P63330	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01219	SAPK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00010	B cell activation	P00384	p38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IDA	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00041	Metabotropic glutamate receptor group I pathway	P01058	Homer	MOUSE|MGI=MGI=1347345|UniProtKB=Q9Z2Y3	Homer protein homolog 1	ISS	12653978	PubMed	PTHR10918:SF3	HOMER PROTEIN HOMOLOG 1
P00005	Angiogenesis	P00220	c-Jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00057	Wnt signaling pathway	P01435	SWI/SNF	PANTR|Ensembl=ENSPTRG00000004924|UniProtKB=H2Q5W5	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	ISS	11532957	PubMed	PTHR13844:SF1	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D MEMBER 1
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000014576|UniProtKB=H2QLZ9	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00047	PDGF signaling pathway	P01153	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00034	Integrin signalling pathway	P00925	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	IDA	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	AQUAE|EnsemblGenome=aq_2023|UniProtKB=O67820	Inosine-5'-monophosphate dehydrogenase	ISS			PTHR11911:SF6	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE
P00048	PI3 kinase pathway	P01192	p110	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000023046|UniProtKB=F6V829	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00006	Apoptosis signaling pathway	P00274	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00021	FGF signaling pathway	P00632	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00402	Jnk	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	15528206	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	NAS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEEL|WormBase=WBGene00018620|UniProtKB=O44588	Uncharacterized protein	ISS	15572354	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P00012	Cadherin signaling pathway	P00462	Casein kinase II	BOVIN|Gene=CSNK2A2|UniProtKB=P20427	Casein kinase II subunit alpha'	ISS	10806215	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00005	Angiogenesis	P00181	SHP2	PANTR|Ensembl=ENSPTRG00000042397|UniProtKB=H2RIH8	Tyrosine-protein phosphatase non-receptor type	ISS	7681589	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00047	PDGF signaling pathway	P01150	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	RCA	88234494	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00648	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00021	FGF signaling pathway	P00641	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=1951|UniProtKB=P08172	Muscarinic acetylcholine receptor M2	IDA	91373358	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00046	Oxidative stress response	P01131	MKP5	RAT|RGD=1307415|UniProtKB=A1EC97	Dual specificity phosphatase 14	ISS			PTHR10159:SF338	DUAL SPECIFICITY PROTEIN PHOSPHATASE 14
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00269	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00291	MEKK1	MACMU|Ensembl=ENSMMUG00000012387|UniProtKB=F7EB20	Uncharacterized protein	ISS	12168099	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04395	Vasopressin synthesis	P04589	Signal Peptidase	YEAST|SGD=S000004056|UniProtKB=Q12133	Signal peptidase complex subunit SPC3	IC	2092035	PubMed	PTHR12804:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00053	T cell activation	P01330	IKK	MACMU|Ensembl=ENSMMUG00000008351|UniProtKB=F7HRV5	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MACMU|Ensembl=ENSMMUG00000016428|UniProtKB=F7GU00	Metabotropic glutamate receptor 1 isoform alpha	ISS	14614461	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00015	Circadian clock system	P00502	Casein kinase I	MONDO|Ensembl=ENSMODG00000003587|UniProtKB=F7FPX9	Uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00053	T cell activation	P01336	Jnk	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00006	Apoptosis signaling pathway	P00318	PKCs	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00047	PDGF signaling pathway	P01150	PKC	PANTR|Ensembl=ENSPTRG00000000931|UniProtKB=H2PZC4	Protein kinase N2	ISS	125549	gi	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00021	FGF signaling pathway	P00639	Shc	RAT|RGD=69348|UniProtKB=O70143	SHC-transforming protein 3	ISS	96404502	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P00012	Cadherin signaling pathway	P00470	F-actin	BOVIN|Ensembl=ENSBTAG00000014614|UniProtKB=P62739	Actin, aortic smooth muscle	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	PANTR|Ensembl=ENSPTRG00000034379|UniProtKB=H2RDK4	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	MACMU|Ensembl=ENSMMUG00000018375|UniProtKB=F7H1D5	Neurogenic locus notch homolog protein 2 isoform 1 preproprotein	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00019	Endothelin signaling pathway	P00566	ERK	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	NAS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	CRYNJ|EnsemblGenome=CNJ01230|UniProtKB=P0CS12	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MACMU|Ensembl=ENSMMUG00000018790|UniProtKB=F6ZPM8	Serine/threonine-protein kinase receptor	ISS	9395284	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P06587	Nicotine pharmacodynamics pathway	P06598	EPB41L2	MOUSE|MGI=MGI=103009|UniProtKB=O70318	Band 4.1-like protein 2	RCA	12181426	PubMed	PTHR23280:SF17	BAND 4.1-LIKE PROTEIN 2
P00021	FGF signaling pathway	P00629	PP2A	SCHPO|PomBase=SPAC227.07c|UniProtKB=Q12702	Protein phosphatase PP2A regulatory subunit B	NAS			PTHR11871:SF0	PROTEIN PHOSPHATASE PP2A 55 KDA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00470	F-actin	XENTR|Xenbase=XB-GENE-6469705|UniProtKB=Q6P8G3	Actin, alpha sarcomeric/skeletal	ISS	10974003	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00566	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	G01546	Cyclin d	PANTR|Ensembl=ENSPTRG00000004549|UniProtKB=H2Q584	Cyclin D2	ISS	93275661	PubMed	PTHR10177:SF66	G1/S-SPECIFIC CYCLIN-D2
P00005	Angiogenesis	P00196	VRAP	HUMAN|HGNC=10821|UniProtKB=Q9NP31	SH2 domain-containing protein 2A	IDA	Q9NP31	SPACC	PTHR14388:SF9	SH2 DOMAIN-CONTAINING PROTEIN 2A
P05918	p38 MAPK pathway	P06015	p38gamma	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	4506785	gi	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P05913	Enkephalin release	P05977	G-Protein (s)	TAKRU|Ensembl=ENSTRUG00000007253|UniProtKB=H2SZQ1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P02738	De novo purine biosynthesis	P02892	5-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase	YEAST|SGD=S000004351|UniProtKB=Q05911	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MONDO|Ensembl=ENSMODG00000020204|UniProtKB=F6SED9	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00055	Transcription regulation by bZIP transcription factor	P01390	TFIIA complex	HUMAN|HGNC=4647|UniProtKB=P52657	Transcription initiation factor IIA subunit 2	IGI	95241493	PubMed	PTHR10966:SF0	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2
P04393	Ras Pathway	P04559	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	10540223	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00056	VEGF signaling pathway	P01413	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	ENTHI|EnsemblGenome=EHI_181250|UniProtKB=C4M5Z7	Rho family GTPase	ISS	12932731	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00048	PI3 kinase pathway	P01193	IRS	RAT|RGD=2922|UniProtKB=P35570	Insulin receptor substrate 1	IGI	12701063	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00056	VEGF signaling pathway	P01407	Erk	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=99401|UniProtKB=Q60612	Adenosine receptor A1	ISS	12515326	PubMed	PTHR24246:SF1	ADENOSINE RECEPTOR A1
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	HALSA|EnsemblGenome=VNG_1724G|UniProtKB=Q9HPA7	Adenylate kinase	ISS			PTHR23359:SF22	GTP:AMP PHOSPHOTRANSFERASE, MITOCHONDRIAL
P00048	PI3 kinase pathway	P01188	Gbetagamma	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00566	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00034	Integrin signalling pathway	P00927	Rac	DICPU|Gene=DICPUDRAFT_55703|UniProtKB=F0ZN94	Putative uncharacterized protein racC	ISS	12932731	PubMed	PTHR24072:SF117	RHO-RELATED PROTEIN RACC
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00029	Huntington disease	P00774	Dynein complex	CANLF|Ensembl=ENSCAFG00000001518|UniProtKB=E2REK9	Uncharacterized protein	ISS	9454836	PubMed	PTHR10676:SF344	DYNEIN HEAVY CHAIN 8, AXONEMAL
P00047	PDGF signaling pathway	P01164	PDK1/2	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	ISS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00007	Axon guidance mediated by semaphorins	P00341	Rho	PANTR|Ensembl=ENSPTRG00000014922|UniProtKB=H2QML4	Uncharacterized protein	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	SCHPO|PomBase=SPAC8C9.03|UniProtKB=P36600	cAMP-dependent protein kinase regulatory subunit	IC	88234494	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	HUMAN|HGNC=3020|UniProtKB=P21728	D(1A) dopamine receptor	ISS	9700720	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00018	EGF receptor signaling pathway	P00552	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00029	Huntington disease	P00796	Kainate receptor	PANTR|Ensembl=ENSPTRG00000018449|UniProtKB=H2QTG5	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00045	Notch signaling pathway	P01115	Neurotic	HUMAN|HGNC=14988|UniProtKB=Q9H488	GDP-fucose protein O-fucosyltransferase 1	RCA			PTHR21420:SF3	GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	DANRE|ZFIN=ZDB-GENE-051202-1|UniProtKB=E7F101	Uncharacterized protein	ISS	14698601	PubMed	PTHR44391:SF2	SUBFAMILY NOT NAMED
P02741	Flavin biosynthesis	P02934	Riboflavin kinase	ARATH|TAIR=AT4G21470|UniProtKB=Q84MD8	Bifunctional riboflavin kinase/FMN phosphatase	ISS			PTHR22749:SF1	BIFUNCTIONAL RIBOFLAVIN KINASE/FMN PHOSPHATASE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00002	Alpha adrenergic receptor signaling pathway	P00078	Alpha1A/1B/1C	BOVIN|Ensembl=ENSBTAG00000040253|UniProtKB=F1MGA6	Uncharacterized protein	ISS	6323229	PubMed	PTHR24248:SF17	ALPHA-1B ADRENERGIC RECEPTOR
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=98956|UniProtKB=P27467	Protein Wnt-3a	IDA	8717036	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P02755	Methylmalonyl pathway	P03033	Propionyl-CoA carboxylase	STRCO|Gene=CAA19983|UniProtKB=O86517	Putative carboxyl transferase	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00049	Parkinson disease	P01211	ERK	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	IDA	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05912	Dopamine receptor mediated signaling pathway	P05960	VAT2	RAT|RGD=3694|UniProtKB=Q01827	Synaptic vesicular amine transporter	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	MACMU|Ensembl=ENSMMUG00000018375|UniProtKB=F7H1D5	Neurogenic locus notch homolog protein 2 isoform 1 preproprotein	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	STRPU|Gene=CYIIIA|UniProtKB=P53474	Actin, cytoskeletal 3A	IC	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	PANTR|Ensembl=ENSPTRG00000010386|UniProtKB=H2QF61	Tyrosine-protein kinase receptor	ISS	14500580	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	RAT|RGD=2927|UniProtKB=P49134	Integrin beta-1	ISS	10706722	PubMed	PTHR10082:SF28	INTEGRIN BETA-1
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CANLF|Ensembl=ENSCAFG00000010787|UniProtKB=E2R3W6	Uncharacterized protein	ISS	11861492	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P06959	CCKR signaling map	P07153	RSK1/2	HUMAN|HGNC=10430|UniProtKB=Q15418	Ribosomal protein S6 kinase alpha-1	RCA	12239223	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00053	T cell activation	P01309	fos	RAT|RGD=2626|UniProtKB=P12841	Proto-oncogene c-Fos	TAS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00018	EGF receptor signaling pathway	P00556	PLCgamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IGI	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00021	FGF signaling pathway	P00628	JNK1-3	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00054	Toll receptor signaling pathway	P01367	MKK3	RAT|RGD=1306620|UniProtKB=B1H230	Map2k3 protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00034	Integrin signalling pathway	P00948	Rho	CANLF|Ensembl=ENSCAFG00000008811|UniProtKB=E2RS61	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF23	RHO-RELATED GTP-BINDING PROTEIN RHO6
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01428	Frizzled	DANRE|ZFIN=ZDB-GENE-990415-229|UniProtKB=Q8QFM3	Frizzled 7a	IDA	8717036	PubMed	PTHR11309:SF31	FRIZZLED-7
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	20027584	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF31	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00580	ET-RA/B	MONDO|Ensembl=ENSMODG00000000658|UniProtKB=F6STK5	Uncharacterized protein	ISS	8564193	PubMed	PTHR24243:SF31	ENDOTHELIN-1 RECEPTOR
P00010	B cell activation	P00398	IP3R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00005	Angiogenesis	P00200	Dsh	MOUSE|MGI=MGI=108100|UniProtKB=Q61062	Segment polarity protein dishevelled homolog DVL-3	ISS	10409711	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	MOUSE|MGI=MGI=1351343|UniProtKB=Q5NCH9	Metabotropic glutamate receptor 6	ISS	11431030	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01151	PKB	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IC	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	HUMAN|HGNC=4587|UniProtKB=Q14957	Glutamate receptor ionotropic, NMDA 2C	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00047	PDGF signaling pathway	P01173	STAT	DANRE|ZFIN=ZDB-GENE-980526-499|UniProtKB=Q6P943	Signal transducer and activator of transcription	ISS	99348060	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00005	Angiogenesis	P00223	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	IC	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00021	FGF signaling pathway	P00642	MEK1-2	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05916	Opioid prodynorphin pathway	P05999	provasopressin	RAT|RGD=3238|UniProtKB=P01179	Oxytocin-neurophysin 1	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00566	ERK	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	IGI	10514528	PubMed	PTHR24055:SF330	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01026	KA	PANTR|Ensembl=ENSPTRG00000000543|UniProtKB=H2PYN8	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00038	JAK/STAT signaling pathway	P01034	Jak	BOVIN|Ensembl=ENSBTAG00000003147|UniProtKB=F1N0D6	Tyrosine-protein kinase	ISS	11929133	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01023	CaMKII	ANOGA|EnsemblGenome=AGAP000028|UniProtKB=Q7QEK3	AGAP000028-PA	ISS	12888804	PubMed	PTHR43940:SF1	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN
P00029	Huntington disease	G01530	HTT	HUMAN|HGNC=4851|UniProtKB=P42858	Huntingtin	IDA	9462744	PubMed	PTHR10170:SF10	HUNTINGTIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00046	Oxidative stress response	P01135	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	TAS	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00010	B cell activation	P00385	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02746	Heme biosynthesis	P02972	Ferrochelatase	MOUSE|MGI=MGI=95513|UniProtKB=P22315	Ferrochelatase, mitochondrial	ISS			PTHR11108:SF1	FERROCHELATASE, MITOCHONDRIAL
P00036	Interleukin signaling pathway	P00996	STAT	HUMAN|HGNC=11362|UniProtKB=P42224	Signal transducer and activator of transcription 1-alpha/beta	IC	10207096	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00036	Interleukin signaling pathway	P00965	ERK	RAT|RGD=62087|UniProtKB=P27704	Mitogen-activated protein kinase 6	ISS	8444355	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P05915	Opioid proenkephalin pathway	P05994	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00010	B cell activation	P00401	jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00019	Endothelin signaling pathway	P00590	IP3 R	ANOGA|EnsemblGenome=AGAP006475|UniProtKB=Q5TQX0	AGAP006475-PA	ISS	11007872	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00053	T cell activation	P01319	PAK	MONDO|Ensembl=ENSMODG00000018459|UniProtKB=F7CU42	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00059	p53 pathway	P04609	PI3K	ARATH|TAIR=AT1G60490|UniProtKB=P42339	Phosphatidylinositol 3-kinase VPS34	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=8156|UniProtKB=P35372	Mu-type opioid receptor	IDA	12093103	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00012	Cadherin signaling pathway	P00474	Wnt	BRAFL|Gene=BRAFLDRAFT_118309|UniProtKB=C3YZ17	Protein Wnt	IDA	11266476	PubMed	PTHR12027:SF100	SUBFAMILY NOT NAMED
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00021	FGF signaling pathway	P00636	FGFR1-4	BOVIN|Ensembl=ENSBTAG00000010543|UniProtKB=F1MN51	Fibroblast growth factor receptor	ISS	11549253	PubMed	PTHR24416:SF343	FIBROBLAST GROWTH FACTOR RECEPTOR 4
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	HUMAN|HGNC=11588|UniProtKB=P20226	TATA-box-binding protein	ISS	600075	OMIM	PTHR10126:SF20	TATA-BOX-BINDING PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05916	Opioid prodynorphin pathway	P06002	G-protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01428	Frizzled	MACMU|Ensembl=ENSMMUG00000022114|UniProtKB=F7H7V5	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF81	FRIZZLED-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ARATH|TAIR=AT3G18780|UniProtKB=Q96292	Actin-2	IC	10974003	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00018	EGF receptor signaling pathway	P00552	Ras	CHICK|Ensembl=ENSGALG00000014033|UniProtKB=E1BTS2	Uncharacterized protein	ISS	99084794	PubMed	PTHR24070:SF186	GTPASE KRAS
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00807	Actin	PRIPA|Gene=PPA17339|UniProtKB=H3F5B4	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF352	ACTIN
P00019	Endothelin signaling pathway	P00572	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IGI	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00030	Hypoxia response via HIF activation	P00824	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	TAS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-040426-2427|UniProtKB=F1Q6C0	Uncharacterized protein (Fragment)	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00054	Toll receptor signaling pathway	P01358	ERK1	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	BOVIN|Gene=MYO1D|UniProtKB=Q17R14	Unconventional myosin-Id	ISS			PTHR13140:SF417	UNCONVENTIONAL MYOSIN-ID
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00053	T cell activation	P01331	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IDA	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02755	Methylmalonyl pathway	P03033	Propionyl-CoA carboxylase	BACSU|EnsemblGenome=BSU18210|UniProtKB=O31825	Uncharacterized carboxylase YngE	ISS			PTHR22855:SF36	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	CHICK|Ensembl=ENSGALG00000015596|UniProtKB=E1C063	Uncharacterized protein	ISS	10683140	PubMed	PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P05915	Opioid proenkephalin pathway	P05988	peptide E	DANRE|ZFIN=ZDB-GENE-030729-3|UniProtKB=F1QTD1	Uncharacterized protein (Fragment)	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00219	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04393	Ras Pathway	P04558	p38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Ensembl=ENSCAFG00000007780|UniProtKB=F1PZH9	Uncharacterized protein	ISS	11701344	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=620146|UniProtKB=O08874	Serine/threonine-protein kinase N2	ISS	10644715	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	RAT|RGD=2346|UniProtKB=P09483	Neuronal acetylcholine receptor subunit alpha-4	ISS	85270494	PubMed	PTHR18945:SF401	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4
P04395	Vasopressin synthesis	P04594	Neurophysin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00048	PI3 kinase pathway	G01544	GADD45	MONDO|Ensembl=ENSMODG00000000788|UniProtKB=F6SSE6	Uncharacterized protein	ISS	9827804	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P00055	Transcription regulation by bZIP transcription factor	P01395	TFIIE	PANTR|Ensembl=ENSPTRG00000015273|UniProtKB=H2QN66	General transcription factor IIE, polypeptide 1, alpha 56kDa	ISS	92065982	PubMed	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	MOUSE|MGI=MGI=1351342|UniProtKB=Q3UVX5	Metabotropic glutamate receptor 5	ISS	14614461	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	RAT|RGD=71098|UniProtKB=P97633	Casein kinase I isoform alpha	ISS	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	BOVIN|Gene=KCNJ5|UniProtKB=F1MYR9	G protein-activated inward rectifier potassium channel 4	ISS	12374786	PubMed	PTHR11767:SF52	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 4
P05912	Dopamine receptor mediated signaling pathway	P05963	MAO	BOVIN|Ensembl=ENSBTAG00000016206|UniProtKB=P21398	Amine oxidase [flavin-containing] A	ISS	8602220	PubMed	PTHR43563:SF3	AMINE OXIDASE  FLAVIN-CONTAINING  A
P05731	GABA-B receptor II signaling	P05752	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=12779|UniProtKB=O14905	Protein Wnt-9b	TAS	8717036	PubMed	PTHR12027:SF84	PROTEIN WNT-9B
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00019	Endothelin signaling pathway	P00566	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05913	Enkephalin release	P05977	G-Protein (s)	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	RAT|RGD=2739|UniProtKB=Q00961	Glutamate receptor ionotropic, NMDA 2C	IC	11319238	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	PANTR|Ensembl=ENSPTRG00000016548|UniProtKB=H2QQC5	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00023	General transcription regulation	P00662	TFIIA complex	RAT|RGD=1308625|UniProtKB=Q641W8	General transcription factor IIA, 1-like	ISS	600519	OMIM	PTHR12694:SF9	PROTEIN STON1-GTF2A1L-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	HUMAN|HGNC=10621|UniProtKB=O00626	C-C motif chemokine 22	ISS	16903084	gi	PTHR12015:SF102	C-C MOTIF CHEMOKINE 22
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02759	Pyridoxal-5-phosphate biosynthesis	P03061	Pyridoxine-5-phosphate oxidase	SYNY3|EnsemblGenome=BAA18303|UniProtKB=P74211	Pyridoxine/pyridoxamine 5'-phosphate oxidase	ISS	8590279	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00057	Wnt signaling pathway	P01435	SWI/SNF	ANOGA|EnsemblGenome=AGAP000923|UniProtKB=Q7QI39	AGAP000923-PA	ISS	11532957	PubMed	PTHR13844:SF7	BRAHMA-ASSOCIATED PROTEIN OF 60 KDA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	TAS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00047	PDGF signaling pathway	P01153	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P06959	CCKR signaling map	P07121	MAP2K2	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	RCA	9324163	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04393	Ras Pathway	P04566	Stat 1/3	MACMU|Ensembl=ENSMMUG00000010707|UniProtKB=F7G8G5	Signal transducer and activator of transcription	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000014498|UniProtKB=F7GEI8	Uncharacterized protein	ISS	8386525	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	BOVIN|Ensembl=ENSBTAG00000019988|UniProtKB=F1N2V3	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P02738	De novo purine biosynthesis	P02900	AICAR transformylase	CAEBR|Gene=CBG17698|UniProtKB=A8XRH8	Protein CBG17698	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P00057	Wnt signaling pathway	P01428	Frizzled	PANTR|Ensembl=ENSPTRG00000020490|UniProtKB=H2R2C6	Frizzled homolog 6	ISS	11212302	PubMed	PTHR11309:SF75	FRIZZLED-6
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00374	Lyn	BOVIN|Ensembl=ENSBTAG00000020034|UniProtKB=F1N261	Tyrosine-protein kinase	ISS	1371009	PubMed	PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P00056	VEGF signaling pathway	P01402	MEK	MOUSE|MGI=MGI=1354946|UniProtKB=Q61532	Mitogen-activated protein kinase 6	ISS			PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00059	p53 pathway	G01566	TSP1	MACMU|Ensembl=ENSMMUG00000006035|UniProtKB=F6WIY2	Uncharacterized protein	ISS	7521539	PubMed	PTHR10199:SF78	THROMBOSPONDIN-1
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT3G14720|UniProtKB=Q9LUC3	Mitogen-activated protein kinase 19	ISS	10514528	PubMed	PTHR24055:SF200	MITOGEN-ACTIVATED PROTEIN KINASE 18-RELATED
P00007	Axon guidance mediated by semaphorins	P00330	CRAM	MOUSE|MGI=MGI=1929772|UniProtKB=Q9EQF6	Dihydropyrimidinase-related protein 5	ISS	10851247	PubMed	PTHR11647:SF58	DIHYDROPYRIMIDINASE-RELATED PROTEIN 5
P00047	PDGF signaling pathway	P01167	Ets	MOUSE|MGI=MGI=95610|UniProtKB=Q00422	GA-binding protein alpha chain	ISS	15298723	PubMed	PTHR11849:SF195	GA-BINDING PROTEIN ALPHA CHAIN
P00045	Notch signaling pathway	P01118	Numb	BOVIN|Ensembl=ENSBTAG00000011683|UniProtKB=E1B8G1	Uncharacterized protein	ISS	10468633	PubMed	PTHR11232:SF33	PROTEIN NUMB HOMOLOG
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05918	p38 MAPK pathway	P05920	MAPKAP-K2	MACMU|Ensembl=ENSMMUG00000023567|UniProtKB=F7HHY8	Uncharacterized protein	ISS	8262198	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00048	PI3 kinase pathway	P01192	p110	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00807	Actin	ARATH|TAIR=AT5G59370|UniProtKB=P53494	Actin-4	IDA	11889126	PubMed	PTHR11937:SF366	ACTIN-4
P00047	PDGF signaling pathway	P01161	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CRYNJ|EnsemblGenome=CNA04650|UniProtKB=Q5KP06	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	MONDO|Ensembl=ENSMODG00000014177|UniProtKB=F6U7A6	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00624	14-3-3	CAEBR|Gene=CBG06174|UniProtKB=A8X0R4	Protein CBR-PAR-5	ISS	10407019	PubMed	PTHR18860:SF21	14-3-3-LIKE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	BOVIN|Ensembl=ENSBTAG00000008535|UniProtKB=E1BIS1	Uncharacterized protein	ISS	12645661	PubMed	PTHR45052:SF1	SUPPRESSOR OF CYTOKINE SIGNALING 7
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	PANTR|Ensembl=ENSPTRG00000013189|UniProtKB=H2QJV1	Uncharacterized protein	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MONDO|Ensembl=ENSMODG00000004799|UniProtKB=F6VM87	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00018	EGF receptor signaling pathway	P00547	PP2A	MONDO|Ensembl=ENSMODG00000019007|UniProtKB=F7C5Z9	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01428	Frizzled	MOUSE|MGI=MGI=1196625|UniProtKB=O70421	Frizzled-1	IDA	12549854	PubMed	PTHR11309:SF81	FRIZZLED-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MACMU|Ensembl=ENSMMUG00000001353|UniProtKB=F7D6T8	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MACMU|Ensembl=ENSMMUG00000014597|UniProtKB=F6VAQ6	Glycogen synthase kinase-3 alpha	ISS	21361340	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	RAT|RGD=1306040|UniProtKB=Q6QDP7	Cyclic AMP-responsive element-binding protein 3-like protein 2	RCA			PTHR22952:SF96	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 2
P00020	FAS signaling pathway	P00616	Nuclear Lamin	BOVIN|Ensembl=ENSBTAG00000002882|UniProtKB=E1B8N6	Uncharacterized protein	ISS	11165516	PubMed	PTHR23239:SF157	LAMIN-B1
P00004	Alzheimer disease-presenilin pathway	P00172	BACE-1	BOVIN|Ensembl=ENSBTAG00000019365|UniProtKB=Q2HJ40	Beta-secretase 1	ISS	10956649	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00786	ARF	DAPPU|EnsemblGenome=DAPPUDRAFT_309391|UniProtKB=E9HCC9	Putative uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P06587	Nicotine pharmacodynamics pathway	P06613	CHRNB2	PANTR|Ensembl=ENSPTRG00000001389|UniProtKB=H2Q056	Uncharacterized protein	ISS	22213672	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P00010	B cell activation	P00398	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00056	VEGF signaling pathway	P01409	cPLA2	MONDO|Ensembl=ENSMODG00000011791|UniProtKB=F7CBU9	Phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	RAT|RGD=2740|UniProtKB=Q62645	Glutamate receptor ionotropic, NMDA 2D	IC	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	DANRE|ZFIN=ZDB-GENE-010705-1|UniProtKB=Q90Z40	Guanine nucleotide-binding protein subunit gamma	IDA	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00006	Apoptosis signaling pathway	P00297	NFkappaB	RAT|RGD=70498|UniProtKB=Q63369	Nuclear factor NF-kappa-B p105 subunit (Fragment)	ISS	12574369	PubMed	PTHR24169:SF9	NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01062	mGluR1	PANTR|Ensembl=ENSPTRG00000018684|UniProtKB=C7G3M7	Glutamate receptor, metabotropic 1	ISS	12351712	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	BOVIN|Ensembl=ENSBTAG00000010906|UniProtKB=E1BN61	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF115	RIBOSOMAL PROTEIN S6 KINASE ALPHA-5
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	MOUSE|MGI=MGI=109528|UniProtKB=Q61056	Short transient receptor potential channel 1	IDA	11055438	PubMed	PTHR10117:SF56	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 1
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	LEIMA|EnsemblGenome=LmjF.36.6470|UniProtKB=Q4Q0B0	Mitogen-activated protein kinase	ISS			PTHR24055:SF178	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00254	GTPase	BOVIN|Ensembl=ENSBTAG00000004279|UniProtKB=P61585	Transforming protein RhoA	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	ANOGA|EnsemblGenome=AGAP001394|UniProtKB=F5HMS4	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00018	EGF receptor signaling pathway	P00552	Ras	MONDO|Gene=KRAS|UniProtKB=Q07983	GTPase KRas	ISS	9869449	PubMed	PTHR24070:SF186	GTPASE KRAS
P00012	Cadherin signaling pathway	P00470	F-actin	ARATH|TAIR=AT2G42090|UniProtKB=P93738	Putative actin-9	IC	14684598	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IGI	14526383	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00007	Axon guidance mediated by semaphorins	P00340	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00053	T cell activation	P01322	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=4401|UniProtKB=O14775	Guanine nucleotide-binding protein subunit beta-5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000028559|UniProtKB=Q5DRD9	Protocadherin beta-10	ISS	8120095	PubMed	PTHR24028:SF54	PROTOCADHERIN BETA-10
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=1308343|UniProtKB=D3ZFQ5	Protein Cdh9	ISS	8120095	PubMed	PTHR24027:SF99	CADHERIN-9
P05915	Opioid proenkephalin pathway	P05990	K+ channel	BOVIN|Ensembl=ENSBTAG00000018193|UniProtKB=E1BHX8	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00045	Notch signaling pathway	G01541	E(spl)-C genes	HUMAN|HGNC=4880|UniProtKB=Q9Y5J3	Hairy/enhancer-of-split related with YRPW motif protein 1	IC			PTHR10985:SF78	HAIRY/ENHANCER-OF-SPLIT RELATED WITH YRPW MOTIF PROTEIN 1
P00046	Oxidative stress response	P01135	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	TAS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00019	Endothelin signaling pathway	P00589	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IGI	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MACMU|Ensembl=ENSMMUG00000009679|UniProtKB=F6YBQ8	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P04376	5HT4 type receptor mediated signaling pathway	P04426	K+ channel	RAT|RGD=61997|UniProtKB=O54912	Potassium channel subfamily K member 3	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00053	T cell activation	P01331	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IDA	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	ARATH|TAIR=AT4G08800|UniProtKB=F4JID0	Protein kinase family protein	IDA	11437445	PubMed	PTHR11909:SF298	CASEIN KINASE 1-LIKE PROTEIN 12-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00053	T cell activation	P01312	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	94313981	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IDA	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00049	Parkinson disease	P01236	Casein kinase II	ORNAN|Ensembl=ENSOANG00000012115|UniProtKB=F7F9Q9	Uncharacterized protein	ISS	10617630	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00047	PDGF signaling pathway	P01153	GSK3	ARATH|TAIR=AT4G00720|UniProtKB=Q96287	Shaggy-related protein kinase theta	ISS	21361340	gi	PTHR24057:SF19	SHAGGY-RELATED PROTEIN KINASE BETA-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	CANLF|Ensembl=ENSCAFG00000009203|UniProtKB=F1PVZ1	Muscarinic acetylcholine receptor	ISS	12181435	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00053	T cell activation	P01309	fos	MONDO|Ensembl=ENSMODG00000005927|UniProtKB=F6WX28	Uncharacterized protein	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00025	Hedgehog signaling pathway	P00692	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00029	Huntington disease	P00778	NMDA receptor	BOVIN|Ensembl=ENSBTAG00000018445|UniProtKB=E1BK87	Uncharacterized protein	ISS	11554554	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00029	Huntington disease	P00780	Microtubule	SCHMA|EnsemblGenome=Smp_078040|UniProtKB=C4QIC0	Tubulin beta chain,putative	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00017	DNA replication	P00535	5' to 3' Exoribonulcease	CANLF|Ensembl=ENSCAFG00000005185|UniProtKB=E2RMS9	Uncharacterized protein	ISS	7885830	PubMed	PTHR12341:SF41	5'-3' EXORIBONUCLEASE 2
P00053	T cell activation	P01331	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00048	PI3 kinase pathway	P01182	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00053	T cell activation	P01311	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00383	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	USTMA|Gene=UMAG_11232|UniProtKB=A0A0D1DMT3	Chromosome 22, whole genome shotgun sequence	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	ARATH|TAIR=AT1G23800|UniProtKB=Q8S528	Aldehyde dehydrogenase family 2 member B7, mitochondrial	IC			PTHR11699:SF211	ALDEHYDE DEHYDROGENASE 5, MITOCHONDRIAL
P00054	Toll receptor signaling pathway	P01352	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00034	Integrin signalling pathway	P00938	Cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	IDA	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00010	B cell activation	P00384	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00049	Parkinson disease	P01238	14-3-3	DICDI|dictyBase=DDB_G0269138|UniProtKB=P54632	14-3-3-like protein	IDA	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00021	FGF signaling pathway	P00629	PP2A	CAEEL|WormBase=WBGene00012348|UniProtKB=O18178	Protein Phosphatase 2A (Two A) Regulatory subunit	ISS	10092233	PubMed	PTHR10257:SF29	BCDNA.LD34343
P02747	Histidine biosynthesis	P02985	Histidinol dehydrogenase	DEIRA|EnsemblGenome=DR_2140|UniProtKB=Q9RSI4	Histidinol dehydrogenase	ISS			PTHR21256:SF2	HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00029	Huntington disease	P00796	Kainate receptor	RAT|RGD=2735|UniProtKB=Q63273	Glutamate receptor ionotropic, kainate 5	IDA	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	IC	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01455	Smad4	MACMU|Ensembl=ENSMMUG00000000340|UniProtKB=F6YMS3	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF36	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5
P00029	Huntington disease	P00805	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IDA	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00144	Ire-1	MOUSE|MGI=MGI=1930134|UniProtKB=Q9EQY0	Serine/threonine-protein kinase/endoribonuclease IRE1	IDA	10619423	PubMed	PTHR13954:SF17	SERINE/THREONINE-PROTEIN KINASE/ENDORIBONUCLEASE IRE1
P05731	GABA-B receptor II signaling	P05754	Ggamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	CHICK|Ensembl=ENSGALG00000010812|UniProtKB=F1NLZ9	Uncharacterized protein	ISS	15858232	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00057	Wnt signaling pathway	P01456	beta-arrestin	RAT|RGD=2156|UniProtKB=P29066	Beta-arrestin-1	IDA	11742073	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04393	Ras Pathway	P04556	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	IC	11535291	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P05915	Opioid proenkephalin pathway	P05990	K+ channel	RAT|RGD=61997|UniProtKB=O54912	Potassium channel subfamily K member 3	ISS	15282272	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00049	Parkinson disease	P01211	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	11204774	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	METAC|EnsemblGenome=MA_1819|UniProtKB=Q8TPT6	Aspartate aminotransferase	ISS			PTHR11751:SF306	SUBFAMILY NOT NAMED
P04397	p53 pathway by glucose deprivation	P04636	S6K	MOUSE|MGI=MGI=1927343|UniProtKB=Q9Z1M4	Ribosomal protein S6 kinase beta-2	IDA	15116068	PubMed	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00564	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	IPI	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00029	Huntington disease	P00775	Rac	PANTR|Ensembl=ENSPTRG00000006424|UniProtKB=H2Q8F7	Ras homolog gene family, member J	ISS	12932731	PubMed	PTHR24072:SF17	RHO-RELATED GTP-BINDING PROTEIN RHOJ
P00029	Huntington disease	P00777	CBP	CAEEL|WormBase=WBGene00010545|UniProtKB=G5EBG3	CBP/p300 homolog	IDA	8413673	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	IPI	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g245041|UniProtKB=A7SG27	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	IXOSC|EnsemblGenome=ISCW009711|UniProtKB=B7Q3T6	THO complex subunit, putative	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00049	Parkinson disease	P01242	Casein kinase I	CAEBR|Gene=CBG20206|UniProtKB=A8XX71	Protein CBR-KIN-19	ISS	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	89186920	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00012	Cadherin signaling pathway	P00471	Cadherin	ANOGA|EnsemblGenome=AGAP006256|UniProtKB=Q7PPB2	AGAP006256-PA	ISS	8120095	PubMed	PTHR43956:SF5	CADHERIN 74A, ISOFORM A
P00056	VEGF signaling pathway	P01421	Rac	MOUSE|MGI=MGI=1924714|UniProtKB=Q812A5	Proline-rich protein 5	ISS			PTHR32428:SF4	PROLINE-RICH PROTEIN 5
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04376	5HT4 type receptor mediated signaling pathway	P04426	K+ channel	BOVIN|Ensembl=ENSBTAG00000018193|UniProtKB=E1BHX8	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	IC	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00005	Angiogenesis	P00196	VRAP	PANTR|Ensembl=ENSPTRG00000001476|UniProtKB=H2R8K0	Uncharacterized protein	ISS	Q9NP31	SPACC	PTHR14388:SF9	SH2 DOMAIN-CONTAINING PROTEIN 2A
P00025	Hedgehog signaling pathway	P00699	Su(fu)	MONDO|Ensembl=ENSMODG00000011242|UniProtKB=F6RMT7	Uncharacterized protein (Fragment)	ISS	12068298	PubMed	PTHR10928:SF2	SUPPRESSOR OF FUSED HOMOLOG
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00006	Apoptosis signaling pathway	P00299	Caspase 8	CHICK|Ensembl=ENSGALG00000008355|UniProtKB=F1NXP6	Uncharacterized protein	ISS	8681376	PubMed	PTHR10454:SF162	CASPASE-8
P04393	Ras Pathway	P04566	Stat 1/3	BOVIN|Gene=STAT3|UniProtKB=P61635	Signal transducer and activator of transcription 3	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00036	Interleukin signaling pathway	P00980	IRS1/2	RAT|RGD=2922|UniProtKB=P35570	Insulin receptor substrate 1	IC	5031805	gi	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	MOUSE|MGI=MGI=95810|UniProtKB=Q9Z2W9	Glutamate receptor 3	ISS	10331083	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P04393	Ras Pathway	P04553	PAK	HUMAN|HGNC=8592|UniProtKB=O75914	Serine/threonine-protein kinase PAK 3	IDA	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00056	VEGF signaling pathway	P01417	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00047	PDGF signaling pathway	P01154	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	HUMAN|HGNC=5974|UniProtKB=P78552	Interleukin-13 receptor subunit alpha-1	IPI	12223527	PubMed	PTHR23036:SF89	INTERLEUKIN-13 RECEPTOR SUBUNIT ALPHA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	ORNAN|Ensembl=ENSOANG00000003489|UniProtKB=F7FSE3	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00004	Alzheimer disease-presenilin pathway	P00117	E-cadherin C-terminal fragment	MOUSE|MGI=MGI=88354|UniProtKB=P09803	Cadherin-1	IDA	11953314	PubMed	PTHR24027:SF319	CADHERIN-1
P02723	Adenine and hypoxanthine salvage pathway	P02804	Hypoxanthine phosphoribosyl transferase	BACSU|EnsemblGenome=BSU00680|UniProtKB=P37472	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P02759	Pyridoxal-5-phosphate biosynthesis	P03062	1-Deoxyxylulose-5-phosphate synthase	CHLRE|EnsemblGenome=CHLREDRAFT_196568|UniProtKB=A8JFW4	1-deoxy-D-xylulose 5-phosphate synthase (Fragment)	ISS			PTHR43322:SF5	1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE 1-RELATED
P05916	Opioid prodynorphin pathway	P06001	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00474	Wnt	TAKRU|Ensembl=ENSTRUG00000011562|UniProtKB=H2TX02	Protein Wnt	IDA	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00012	Cadherin signaling pathway	P00464	Fyn	HUMAN|HGNC=4037|UniProtKB=P06241	Tyrosine-protein kinase Fyn	ISS	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00036	Interleukin signaling pathway	P00973	PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00182	p38MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P02781	Threonine biosynthesis	P03189	Aspartate kinase	SCHPO|PomBase=SPBC19F5.04|UniProtKB=O60163	Probable aspartokinase	ISS			PTHR21499:SF3	ASPARTOKINASE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MONDO|Ensembl=ENSMODG00000023805|UniProtKB=F7F082	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	STRCO|Gene=CAB90858|UniProtKB=Q7AKP2	Glutamine synthetase	ISS			PTHR20852:SF57	GLUTAMINE SYNTHETASE 2 CYTOPLASMIC
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04393	Ras Pathway	P04572	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00859	NFkappaB	MOUSE|MGI=MGI=97312|UniProtKB=P25799	Nuclear factor NF-kappa-B p105 subunit	IDA	8598461	PubMed	PTHR24169:SF9	NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00049	Parkinson disease	P01211	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06711	Id3	MOUSE|MGI=MGI=96398|UniProtKB=P41133	DNA-binding protein inhibitor ID-3	RCA			PTHR11723:SF16	DNA-BINDING PROTEIN INHIBITOR ID-3
P00034	Integrin signalling pathway	P00925	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00020	FAS signaling pathway	P00622	FADD	MOUSE|MGI=MGI=109324|UniProtKB=Q61160	FAS-associated death domain protein	IGI	8565075	PubMed	PTHR15077:SF8	FAS-ASSOCIATED DEATH DOMAIN PROTEIN
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000002775|UniProtKB=H2RB55	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00056	VEGF signaling pathway	P01411	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P06211	BMP/activin signaling pathway-drosophila	P06241	TGFbetaR I	DROME|FlyBase=FBgn0011300|UniProtKB=A1Z7L8	Receptor protein serine/threonine kinase	RCA	10683140	PubMed	PTHR23255:SF71	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01052	AC	PANTR|Ensembl=ENSPTRG00000001638|UniProtKB=H2Q0J3	Adenylate cyclase type 10	ISS	9874775	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02724	Alanine biosynthesis	P02815	Branched chain amino acid aminotransferase	HUMAN|HGNC=976|UniProtKB=P54687	Branched-chain-amino-acid aminotransferase, cytosolic	ISS			PTHR11825:SF51	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, CYTOSOLIC
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95818|UniProtKB=Q61626	Glutamate receptor ionotropic, kainate 5	ISS	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IC	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00628	JNK1-3	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IGI	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	HUMAN|HGNC=7578|UniProtKB=P13535	Myosin-8	IEP	10938134	PubMed	PTHR13140:SF368	MYOSIN-8
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	MACMU|Ensembl=ENSMMUG00000015892|UniProtKB=F7BVK0	Uncharacterized protein	ISS	10806215	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00012	Cadherin signaling pathway	P00468	Src	MOUSE|MGI=MGI=98397|UniProtKB=P05480	Neuronal proto-oncogene tyrosine-protein kinase Src	ISS	8054685	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00020	FAS signaling pathway	P00604	Pro-Caspase8	MACMU|Ensembl=ENSMMUG00000031296|UniProtKB=F7C587	Uncharacterized protein	ISS	8681376	PubMed	PTHR10454:SF162	CASPASE-8
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	ANOGA|EnsemblGenome=AGAP006521|UniProtKB=Q7Q5C3	AGAP006521-PA	ISS			PTHR10218:SF229	GUANINE NUCLEOTIDE-BINDING PROTEIN G F  SUBUNIT ALPHA
P02776	Serine glycine biosynthesis	P03159	Phosphoserine phosphatase	HALSA|EnsemblGenome=VNG_2423G|UniProtKB=Q9HMR1	Phosphoserine phosphatase	ISS			PTHR43344:SF2	PHOSPHOSERINE PHOSPHATASE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	TAS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00012	Cadherin signaling pathway	P00470	F-actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	IC	11889126	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	SCHPO|PomBase=SPAC8C9.03|UniProtKB=P36600	cAMP-dependent protein kinase regulatory subunit	IC	176892	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00029	Huntington disease	P00807	Actin	MACMU|Ensembl=ENSMMUG00000002263|UniProtKB=F6VEE0	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00005	Angiogenesis	P00243	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00046	Oxidative stress response	P01129	JNK1/2	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	TAS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01300	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00254	GTPase	XENTR|Xenbase=XB-GENE-489222|UniProtKB=Q28GJ8	Ras homolog gene family, member A	ISS	15668138	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	RCA	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04398	p53 pathway feedback loops 2	P04658	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00030	Hypoxia response via HIF activation	P00823	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	ISS			PTHR10048:SF14	PI-3 KINASE
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00008	Axon guidance mediated by Slit/Robo	P00342	Slit	RAT|RGD=69307|UniProtKB=O88279	Slit homolog 1 protein	ISS	10102268	PubMed	PTHR24373:SF39	SLIT HOMOLOG 1 PROTEIN
P00059	p53 pathway	P04617	WRN	PANTR|Ensembl=ENSPTRG00000020145|UniProtKB=H2QW01	Uncharacterized protein	ISS			PTHR13710:SF120	WERNER SYNDROME ATP-DEPENDENT HELICASE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	STRPU|Gene=CYIIIB|UniProtKB=P18499	Actin, cytoskeletal 3B	ISS	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00018	EGF receptor signaling pathway	P00551	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P02749	Leucine biosynthesis	P03002	Isopropylmalate isomerase	METJA|EnsemblGenome=MJ_1003|UniProtKB=Q58409	Methanogen homoaconitase large subunit	ISS			PTHR43822:SF4	SUBFAMILY NOT NAMED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	XENTR|Ensembl=ENSXETG00000009343|UniProtKB=F7CYY5	Inosine-5'-monophosphate dehydrogenase 2	ISS			PTHR11911:SF121	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	HUMAN|HGNC=1388|UniProtKB=O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	15699344	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P06587	Nicotine pharmacodynamics pathway	P06602	PPP1CA	PANTR|Ensembl=ENSPTRG00000005449|UniProtKB=H2Q6V7	Serine/threonine-protein phosphatase	ISS	8392016	PubMed	PTHR11668:SF377	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-ALPHA CATALYTIC SUBUNIT
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P05915	Opioid proenkephalin pathway	P05992	met-Enkephalin	DANRE|ZFIN=ZDB-GENE-030729-3|UniProtKB=F1QTD1	Uncharacterized protein (Fragment)	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT1G53510|UniProtKB=Q9C5C0	Mitogen-activated protein kinase 18	ISS	10514528	PubMed	PTHR24055:SF200	MITOGEN-ACTIVATED PROTEIN KINASE 18-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IDA	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00059	p53 pathway	P01480	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	DROME|FlyBase=FBgn0001991|UniProtKB=Q24270	Voltage-dependent calcium channel type D subunit alpha-1	IC	15737619	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	IDA	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00021	FGF signaling pathway	P00640	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=3763|UniProtKB=P30680	Somatostatin receptor type 2	IDA	12441358	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P00006	Apoptosis signaling pathway	P00269	MAPK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	ISS	94131270	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00036	Interleukin signaling pathway	P00970	Interleukin	MACMU|Gene=IL15|UniProtKB=P48092	Interleukin-15	ISS	7561102	PubMed	PTHR45114:SF1	INTERLEUKIN-15
P00034	Integrin signalling pathway	P00922	Collagen	MOUSE|MGI=MGI=88459|UniProtKB=Q04857	Collagen alpha-1(VI) chain	IDA	10727440	PubMed	PTHR44172:SF3	COLLAGEN ALPHA-1 VI  CHAIN
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00006	Apoptosis signaling pathway	P00259	TNF	MOUSE|MGI=MGI=104796|UniProtKB=P41155	Lymphotoxin-beta	ISS			PTHR11471:SF29	LYMPHOTOXIN-BETA
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	DANRE|ZFIN=ZDB-GENE-990415-166|UniProtKB=P79737	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P04395	Vasopressin synthesis	P04589	Signal Peptidase	RAT|RGD=1563536|UniProtKB=Q568Z4	Signal peptidase complex subunit 3	ISS	1546959	PubMed	PTHR12804:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 3
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00005	Angiogenesis	P00237	FRP	RAT|RGD=61916|UniProtKB=Q08463	Frizzled-1	ISS	8717036	PubMed	PTHR11309:SF81	FRIZZLED-1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02918	dUTP pyrophosphatase	STRCO|EnsemblGenome=CAA16477|UniProtKB=O54134	Deoxyuridine 5'-triphosphate nucleotidohydrolase	ISS			PTHR11241:SF0	BCDNA.LD08534
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02788	Xanthine and guanine salvage pathway	P03250	Guanosine phosphorylase	STRCO|Gene=CAD30908|UniProtKB=Q9EWV2	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	MOUSE|MGI=MGI=1351660|UniProtKB=Q9JMK2	Casein kinase I isoform epsilon	IDA	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000012820|UniProtKB=F1MDL3	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00057	Wnt signaling pathway	P01428	Frizzled	DROME|FlyBase=FBgn0027343|UniProtKB=O77438	Frizzled-3	IDA	11212302	PubMed	PTHR11309:SF125	FRIZZLED-3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	RAT|RGD=71014|UniProtKB=Q04400	Adenylate cyclase type 5	IDA	2491850	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00010	B cell activation	P00402	Jnk	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00799	JNK-2	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00021	FGF signaling pathway	P00632	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00046	Oxidative stress response	P01132	c-jun	XENTR|Xenbase=XB-GENE-482228|UniProtKB=F6RYL1	Uncharacterized protein	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	HUMAN|HGNC=4411|UniProtKB=P63211	Guanine nucleotide-binding protein G(T) subunit gamma-T1	IDA	3100519	PubMed	PTHR13809:SF26	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT GAMMA-T1
P00012	Cadherin signaling pathway	P00474	Wnt	XENTR|Gene=wnt11b-1|UniProtKB=Q66II0	Protein Wnt-11b-1	ISS	8717036	PubMed	PTHR12027:SF34	PROTEIN WNT
P00029	Huntington disease	P00811	Arp2/3 complex	CANLF|Ensembl=ENSCAFG00000015094|UniProtKB=F1PT97	Uncharacterized protein	ISS	12932731	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04393	Ras Pathway	P04569	Cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=1351343|UniProtKB=Q5NCH9	Metabotropic glutamate receptor 6	ISS	12351712	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00029	Huntington disease	P00788	Calpain	PANTR|Ensembl=ENSPTRG00000022188|UniProtKB=H2QZ04	Uncharacterized protein	ISS	11675509	PubMed	PTHR10183:SF381	CALPAIN-6
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05734	Synaptic vesicle trafficking	P05773	Munc13	MACMU|Ensembl=ENSMMUG00000002822|UniProtKB=F7H074	Uncharacterized protein	ISS	608897	OMIM	PTHR10774:SF98	PROTEIN UNC-13 HOMOLOG D
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MOUSE|MGI=MGI=101848|UniProtKB=P62881	Guanine nucleotide-binding protein subunit beta-5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01084	CHT1	RAT|RGD=619711|UniProtKB=P28570	Sodium- and chloride-dependent creatine transporter 1	ISS			PTHR11616:SF96	SODIUM- AND CHLORIDE-DEPENDENT CREATINE TRANSPORTER 1
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00034	Integrin signalling pathway	P00951	Jnk	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04393	Ras Pathway	P04559	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00010	B cell activation	P00402	Jnk	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00054	Toll receptor signaling pathway	P01341	Elk1	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	ISS	10487205	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00018	EGF receptor signaling pathway	P00564	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=1594228|UniProtKB=D4A7P5	Protein Pcdhb20	ISS	8120095	PubMed	PTHR24028:SF81	PROTOCADHERIN BETA-14
P00036	Interleukin signaling pathway	P00973	PKB	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00034	Integrin signalling pathway	P00927	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00047	PDGF signaling pathway	P01159	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02916	dTMP kinase	CAEEL|WormBase=WBGene00011272|UniProtKB=Q22018	Thymidylate kinase	ISS			PTHR10344:SF1	THYMIDYLATE KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9441|UniProtKB=P51817	cAMP-dependent protein kinase catalytic subunit PRKX	IC	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	PANTR|Ensembl=ENSPTRG00000006865|UniProtKB=H2Q930	Uncharacterized protein	ISS			PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000005917|UniProtKB=F6QM53	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00010	B cell activation	P00402	Jnk	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00046	Oxidative stress response	P01135	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	HUMAN|HGNC=1605|UniProtKB=P51679	C-C chemokine receptor type 4	TAS	12009564	PubMed	PTHR10489:SF608	C-C CHEMOKINE RECEPTOR TYPE 4
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	HUMAN|HGNC=1401|UniProtKB=Q02641	Voltage-dependent L-type calcium channel subunit beta-1	IC	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00976	GSK3	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	DROME|FlyBase=FBgn0011704|UniProtKB=P48592	Ribonucleoside-diphosphate reductase subunit M2	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00018	EGF receptor signaling pathway	P00552	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IGI	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	RCA	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00025	Hedgehog signaling pathway	P00682	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	TAS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00022	General transcription by RNA polymerase I	P00657	TBP	ORNAN|Ensembl=ENSOANG00000013097|UniProtKB=F6UVN1	Uncharacterized protein	ISS	600075	OMIM	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	RCA			PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00029	Huntington disease	P00778	NMDA receptor	PANTR|Ensembl=ENSPTRG00000004718|UniProtKB=H2Q5I0	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00045	Notch signaling pathway	P01120	NIcs	MACMU|Ensembl=ENSMMUG00000017022|UniProtKB=F7HQZ9	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00565	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00049	Parkinson disease	P01211	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04398	p53 pathway feedback loops 2	P04658	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00004	Alzheimer disease-presenilin pathway	P00174	CD44 N-terminal fragment	MACMU|Ensembl=ENSMMUG00000004327|UniProtKB=F6ZDZ8	Uncharacterized protein	ISS	12223485	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P00048	PI3 kinase pathway	P01177	P110ACT	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00623	FGF	BOVIN|Ensembl=ENSBTAG00000020194|UniProtKB=A6H6W8	Fibroblast growth factor	ISS	12496262	PubMed	PTHR11486:SF77	FIBROBLAST GROWTH FACTOR 13
P00019	Endothelin signaling pathway	P00590	IP3 R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00021	FGF signaling pathway	P00643	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02738	De novo purine biosynthesis	P02892	5-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase	ANOGA|EnsemblGenome=AGAP002378|UniProtKB=Q7QBZ6	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00951	Jnk	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IDA	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05916	Opioid prodynorphin pathway	P06000	vasopressin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00049	Parkinson disease	P01208	Hsp70	DROME|FlyBase=FBgn0266599|UniProtKB=P11147	Heat shock 70 kDa protein cognate 4	IDA	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	BOVIN|Ensembl=ENSBTAG00000006495|UniProtKB=P11017	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	MOUSE|MGI=MGI=1928370|UniProtKB=P84096	Rho-related GTP-binding protein RhoG	ISS			PTHR24072:SF158	RHO-RELATED GTP-BINDING PROTEIN RHOG
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00036	Interleukin signaling pathway	P00971	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	4504111	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	PANTR|Ensembl=ENSPTRG00000017401|UniProtKB=H2R587	Casein kinase 1, alpha 1	ISS	11437445	PubMed	PTHR11909:SF84	CASEIN KINASE I ISOFORM ALPHA
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	XENTR|Ensembl=ENSXETG00000030140|UniProtKB=F7EP58	Uncharacterized protein (Fragment)	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00045	Notch signaling pathway	P01103	Next	MONDO|Ensembl=ENSMODG00000004910|UniProtKB=F7C1Q4	Delta-like protein	ISS	8631496	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00006	Apoptosis signaling pathway	P00310	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01414	PLC-gamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00047	PDGF signaling pathway	P01148	Grb2	HUMAN|HGNC=4066|UniProtKB=Q13480	GRB2-associated-binding protein 1	ISS			PTHR12156:SF18	GRB2-ASSOCIATED-BINDING PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	HUMAN|HGNC=5724|UniProtKB=Q06330	Recombining binding protein suppressor of hairless	NAS	15187023	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00012	Cadherin signaling pathway	P00474	Wnt	DROME|FlyBase=FBgn0004009|UniProtKB=P09615	Protein wingless	IDA	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	SYNY3|EnsemblGenome=BAA10429|UniProtKB=Q55778	Glutamate--tRNA ligase	ISS			PTHR43311:SF2	GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00047	PDGF signaling pathway	P01159	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00049	Parkinson disease	P01236	Casein kinase II	NEUCR|EnsemblGenome=EFNCRG00000002934|UniProtKB=Q8TG13	Casein kinase II subunit alpha	IDA	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	IC	11956331	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	BOVIN|Ensembl=ENSBTAG00000005903|UniProtKB=F1N1K8	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00021	FGF signaling pathway	P00624	14-3-3	MACMU|Ensembl=ENSMMUG00000006489|UniProtKB=F7EFF6	14-3-3 protein zeta/delta	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00056	VEGF signaling pathway	P01423	p38MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00015	Circadian clock system	P00502	Casein kinase I	PANTR|Ensembl=ENSPTRG00000009796|UniProtKB=H2QE47	Casein kinase 1, delta	ISS	11437445	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00018	EGF receptor signaling pathway	P00539	14-3-3	RAT|RGD=3979|UniProtKB=P68255	14-3-3 protein theta	ISS	9211421	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	PYRAE|EnsemblGenome=PAE3438|UniProtKB=Q8ZT48	Glutamate dehydrogenase	ISS			PTHR11606:SF13	GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL
P04393	Ras Pathway	P04559	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00034	Integrin signalling pathway	P00920	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00007	Axon guidance mediated by semaphorins	P00338	Neuropilin 1	MACMU|Ensembl=ENSMMUG00000017588|UniProtKB=F7HHM6	Neuropilin-1 isoform a	ISS	9288754	PubMed	PTHR44185:SF1	NEUROPILIN-1
P00018	EGF receptor signaling pathway	P00556	PLCgamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00036	Interleukin signaling pathway	P00997	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	95096035	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00005	Angiogenesis	P00241	VEGF	HUMAN|HGNC=12680|UniProtKB=P15692	Vascular endothelial growth factor A	ISS			PTHR12025:SF5	VASCULAR ENDOTHELIAL GROWTH FACTOR A
P00057	Wnt signaling pathway	P01443	Phospholipase C	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04393	Ras Pathway	P04578	Rho	MOUSE|MGI=MGI=106028|UniProtKB=Q62159	Rho-related GTP-binding protein RhoC	IDA	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00018	EGF receptor signaling pathway	P00552	Ras	DICDI|dictyBase=DDB_G0292998|UniProtKB=P32252	Ras-like protein rasB	IGI	7997267	PubMed	PTHR24070:SF206	RAS-LIKE PROTEIN RASB
P04378	Beta2 adrenergic receptor signaling pathway	P04440	Beta2	BOVIN|Ensembl=ENSBTAG00000002144|UniProtKB=Q28044	Beta-2 adrenergic receptor	ISS	7669252	PubMed	PTHR24248:SF21	BETA-2 ADRENERGIC RECEPTOR
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00640	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	129387	gi	PTHR10048:SF14	PI-3 KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	ISS	1171954	gi	PTHR10048:SF14	PI-3 KINASE
P00018	EGF receptor signaling pathway	P00558	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00048	PI3 kinase pathway	P01205	NOS	BOVIN|Gene=NOS3|UniProtKB=P29473	Nitric oxide synthase, endothelial	ISS	10435050	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IGI	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00591	PLCbeta	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IGI	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	CAEEL|WormBase=WBGene00001607|UniProtKB=O02225	GLutamiNe synthetase (Glutamate-ammonia ligase)	ISS			PTHR20852:SF39	GLUTAMINE SYNTHETASE  GLUTAMATE-AMMONIA LIGASE
P00012	Cadherin signaling pathway	P00470	F-actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	ISS	11889126	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00034	Integrin signalling pathway	P00924	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00045	Notch signaling pathway	P01110	Presenilin	DANRE|ZFIN=ZDB-GENE-991119-4|UniProtKB=Q9W6T7	Presenilin-1	IGI	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00047	PDGF signaling pathway	P01142	p90RSK	RAT|RGD=1309493|UniProtKB=D4AAT5	Protein Rps6kl1	ISS			PTHR15508:SF4	RIBOSOMAL PROTEIN S6 KINASE-LIKE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000003236|UniProtKB=F7DNS6	Uncharacterized protein	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00015	Circadian clock system	G01497	cry	DANRE|ZFIN=ZDB-GENE-010426-8|UniProtKB=F1QHM9	Uncharacterized protein	ISS			PTHR11455:SF9	6-4 -PHOTOLYASE, ISOFORM A
P05915	Opioid proenkephalin pathway	P05993	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	IDA	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00036	Interleukin signaling pathway	P00990	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	PANTR|Ensembl=ENSPTRG00000001102|UniProtKB=H2QZR9	RAP1A, member of RAS oncogene family	ISS	8576107	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CHICK|Ensembl=ENSGALG00000012821|UniProtKB=P32882	Tubulin beta-2 chain	ISS	9454836	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00053	T cell activation	P01315	Calcineurin	MOUSE|MGI=MGI=107164|UniProtKB=P63328	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	ISS	12015605	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04398	p53 pathway feedback loops 2	P04651	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00006	Apoptosis signaling pathway	P00274	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	ISS	7600581	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CANLF|Ensembl=ENSCAFG00000012181|UniProtKB=F2Z4N7	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00029	Huntington disease	P00810	GAPDH	MACMU|Ensembl=ENSMMUG00000018679|UniProtKB=F6WJJ6	Glyceraldehyde-3-phosphate dehydrogenase	ISS	8612237	PubMed	PTHR10836:SF51	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE
P00048	PI3 kinase pathway	P01181	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01438	PP2A	DANRE|ZFIN=ZDB-GENE-040426-2487|UniProtKB=Q803G3	Serine/threonine-protein phosphatase	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00049	Parkinson disease	P01212	p38 MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MACMU|Ensembl=ENSMMUG00000014754|UniProtKB=F7G124	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF721	MYOSIN-6
P06959	CCKR signaling map	P07153	RSK1/2	HUMAN|HGNC=10432|UniProtKB=P51812	Ribosomal protein S6 kinase alpha-3	RCA	7697796	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00018	EGF receptor signaling pathway	P00551	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	MOUSE|MGI=MGI=99659|UniProtKB=E9PZQ0	Ryanodine receptor 1	ISS	15226293	PubMed	PTHR13715:SF15	RYANODINE RECEPTOR 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00023	General transcription regulation	P00661	TTF2	MOUSE|MGI=MGI=1918240|UniProtKB=Q8CHZ9	Transcription termination factor 1a, mitochondrial	ISS			PTHR15437:SF2	TRANSCRIPTION TERMINATION FACTOR 1, MITOCHONDRIAL
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	TAS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00046	Oxidative stress response	P01135	p38	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	TAS	10995439	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	G01511	SPRY	CANLF|Ensembl=ENSCAFG00000006250|UniProtKB=F1Q4C2	Uncharacterized protein	ISS	22024232	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P00010	B cell activation	P00396	CD45	CHICK|Ensembl=ENSGALG00000002192|UniProtKB=F1NVB1	Uncharacterized protein	IGI	8940015	PubMed	PTHR19134:SF284	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C
P04393	Ras Pathway	P04578	Rho	ORNAN|Ensembl=ENSOANG00000008835|UniProtKB=F7FR08	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04393	Ras Pathway	P04557	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00012	Cadherin signaling pathway	P00475	Frizzled	PANTR|Ensembl=ENSPTRG00000012813|UniProtKB=H2QJ90	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF31	FRIZZLED-7
P00047	PDGF signaling pathway	P01155	Jak	RAT|RGD=69056|UniProtKB=G3V9W2	Tyrosine-protein kinase	ISS	9637709	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P02738	De novo purine biosynthesis	P02901	Adenosuccinate lyase	THEMA|EnsemblGenome=TM_1095|UniProtKB=Q9X0I0	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00057	Wnt signaling pathway	P01435	SWI/SNF	XENTR|Xenbase=XB-GENE-482511|UniProtKB=Q6GLG1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	ISS	11532957	PubMed	PTHR13711:SF206	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY E MEMBER 1
P00009	Axon guidance mediated by netrin	P00364	cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P02779	Thiamin biosynthesis	P03170	Hydroxymethylpyrimidine phosphate kinase	BACSU|EnsemblGenome=BSU11710|UniProtKB=O31620	Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase	ISS			PTHR20858:SF17	HYDROXYMETHYLPYRIMIDINE/PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=13880|UniProtKB=B0I1T2	Unconventional myosin-Ig	IC			PTHR13140:SF381	UNCONVENTIONAL MYOSIN-IG
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	MONDO|Ensembl=ENSMODG00000019259|UniProtKB=F6Q8Q1	Fructose-bisphosphate aldolase	ISS	3105602	PubMed	PTHR11627:SF3	FRUCTOSE-BISPHOSPHATE ALDOLASE C
P00029	Huntington disease	G01533	Bax	RAT|RGD=2192|UniProtKB=Q63690	Apoptosis regulator BAX	ISS	8358790	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	BOVIN|Gene=SLC18A2|UniProtKB=Q27963	Synaptic vesicular amine transporter	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	CANLF|Ensembl=ENSCAFG00000017040|UniProtKB=E2QYK5	Uncharacterized protein	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00056	VEGF signaling pathway	P01413	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1718748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	TRIVA|Gene=TVAG_008680|UniProtKB=A2DC16	Beta-tubulin, putative	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00059	p53 pathway	G04694	p110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	CANAL|CGD=CAL0000190895|UniProtKB=Q9HEW1	cAMP-dependent protein kinase regulatory subunit	ISS	176892	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00749	RGS9	MOUSE|MGI=MGI=1338824|UniProtKB=O54828	Regulator of G-protein signaling 9	IDA	9459445	PubMed	PTHR10845:SF170	REGULATOR OF G-PROTEIN SIGNALING 9
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000035697|UniProtKB=Q28024	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P05916	Opioid prodynorphin pathway	P06002	G-protein	DROME|FlyBase=FBgn0001122|UniProtKB=P16378	G protein alpha o subunit	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P05913	Enkephalin release	P05972	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	88234494	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	8170357	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00010	B cell activation	P00375	Calmodulin	TAKRU|Ensembl=ENSTRUG00000008685|UniProtKB=H2TXN3	Uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF326	CALMODULIN
P00019	Endothelin signaling pathway	P00591	PLCbeta	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	IC	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P06959	CCKR signaling map	P07184	AKAP	HUMAN|HGNC=367|UniProtKB=Q92667	A-kinase anchor protein 1, mitochondrial	RCA	17317140	PubMed	PTHR22948:SF18	A-KINASE ANCHOR PROTEIN 1, MITOCHONDRIAL
P00018	EGF receptor signaling pathway	P00565	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00057	Wnt signaling pathway	P01465	Ggamma	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00048	PI3 kinase pathway	P01193	IRS	BOVIN|Ensembl=ENSBTAG00000021308|UniProtKB=F1MYE0	Uncharacterized protein	ISS	1311924	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	STRPU|EnsemblGenome=SPU_026078|UniProtKB=W4ZD41	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF277	SUBFAMILY NOT NAMED
P00059	p53 pathway	P04616	PDK1/2	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	TAS	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P02770	Pyridoxal phosphate salvage pathway	P03122	Pyridoxamine kinase	DICDI|dictyBase=DDB_G0268628|UniProtKB=Q55EK9	Pyridoxal kinase	ISS	10930737	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00053	T cell activation	P01336	Jnk	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00035	Interferon-gamma signaling pathway	P00960	PTP	CAEEL|WormBase=WBGene00004214|UniProtKB=G5EC24	Tyrosine-protein phosphatase non-receptor type ptp-2	TAS	11689700	PubMed	PTHR19134:SF428	TYROSINE-PROTEIN PHOSPHATASE CORKSCREW
P00057	Wnt signaling pathway	P01444	Wnt	XENTR|Xenbase=XB-GENE-960148|UniProtKB=F6XMD3	Protein Wnt (Fragment)	ISS	8717036	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	TAS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00038	JAK/STAT signaling pathway	P01027	STAT	MACMU|Ensembl=ENSMMUG00000010705|UniProtKB=F7G8V4	Signal transducer and activator of transcription	ISS	8732682	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P02748	Isoleucine biosynthesis	P02998	Dihydroxyacid dehydratase	METAC|EnsemblGenome=MA_1802|UniProtKB=Q8TPV2	Dihydroxy-acid dehydratase 1	ISS			PTHR43661:SF3	DIHYDROXY-ACID DEHYDRATASE
P00012	Cadherin signaling pathway	P00471	Cadherin	CANLF|Ensembl=ENSCAFG00000019028|UniProtKB=E2R790	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF96	CADHERIN-12
P00010	B cell activation	P00379	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8673|UniProtKB=Q9UN72	Protocadherin alpha-7	IDA	8120095	PubMed	PTHR24028:SF225	PROTOCADHERIN ALPHA-7
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P02738	De novo purine biosynthesis	P02902	ADP reductase	TRYB2|Gene=Tb11.v4.0006|UniProtKB=Q382Q1	Ribonucleoside-diphosphate reductase small chain	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P06664	Gonadotropin-releasing hormone receptor pathway	P06735	Ca/CaMK II	MOUSE|MGI=MGI=88257|UniProtKB=P28652	Calcium/calmodulin-dependent protein kinase type II subunit beta	RCA	12888804	PubMed	PTHR43940:SF3	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT BETA
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00005	Angiogenesis	P00206	Wnt	HUMAN|HGNC=12775|UniProtKB=O00744	Protein Wnt-10b	IEP	8717036	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00044	Nicotinic acetylcholine receptor signaling pathway	P01095	beta	CAEBR|Gene=CBG12389|UniProtKB=A8XFB4	Protein CBR-UNC-29	ISS	22213672	PubMed	PTHR18945:SF471	ACETYLCHOLINE RECEPTOR SUBUNIT BETA-TYPE UNC-29
P00029	Huntington disease	P00775	Rac	BOVIN|Ensembl=ENSBTAG00000017200|UniProtKB=A4FV20	RHOJ protein	ISS	12932731	PubMed	PTHR24072:SF17	RHO-RELATED GTP-BINDING PROTEIN RHOJ
P00059	p53 pathway	G04694	p110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	MOUSE|MGI=MGI=95808|UniProtKB=P23818	Glutamate receptor 1	ISS	12871085	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00037	Ionotropic glutamate receptor pathway	P01020	NSF	MONDO|Ensembl=ENSMODG00000011031|UniProtKB=F7F4B9	Uncharacterized protein	ISS	11348590	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00057	Wnt signaling pathway	P01447	Dishevelled	RAT|RGD=620632|UniProtKB=Q9WVB9	Segment polarity protein dishevelled homolog DVL-1	ISS	7906389	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00561	STAT	MONDO|Ensembl=ENSMODG00000028212|UniProtKB=F7BYN4	Signal transducer and activator of transcription	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00021	FGF signaling pathway	P00645	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	XENTR|Xenbase=XB-GENE-479496|UniProtKB=F6S876	Ribosomal protein S6 kinase	ISS	3368449	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00892	Grb2	CAEEL|WormBase=WBGene00004774|UniProtKB=P29355	Sex muscle abnormal protein 5	ISS	11457149	PubMed	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00016	Cytoskeletal regulation by Rho GTPase	P00507	Rho	HUMAN|HGNC=669|UniProtKB=P08134	Rho-related GTP-binding protein RhoC	ISS	14871999	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	9395335	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00565	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IGI	2837282	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00020	FAS signaling pathway	P00615	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00006	Apoptosis signaling pathway	P00322	Cytochrome C	ORNAN|Ensembl=ENSOANG00000009156|UniProtKB=F7EJM9	Uncharacterized protein	ISS	4347193	PubMed	PTHR11961:SF12	CYTOCHROME C
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00047	PDGF signaling pathway	P01174	Rho	MOUSE|MGI=MGI=2385331|UniProtKB=Q923Q2	StAR-related lipid transfer protein 13	ISS			PTHR12659:SF6	STAR-RELATED LIPID TRANSFER PROTEIN 13
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	ARATH|TAIR=AT4G36450|UniProtKB=O23236	Mitogen-activated protein kinase 14	ISS			PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00787	MAPKK4	CANLF|Ensembl=ENSCAFG00000017851|UniProtKB=F1PBB6	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P05912	Dopamine receptor mediated signaling pathway	P05952	EPB41L2	MACMU|Ensembl=ENSMMUG00000007758|UniProtKB=F7BWK5	Uncharacterized protein	ISS	12181426	PubMed	PTHR23280:SF17	BAND 4.1-LIKE PROTEIN 2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00778	NMDA receptor	CHICK|Ensembl=ENSGALG00000008898|UniProtKB=F1P2J9	Uncharacterized protein	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00048	PI3 kinase pathway	P01182	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	IDA	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	22040490	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00009	Axon guidance mediated by netrin	P00357	Netrin	PANTR|Ensembl=ENSPTRG00000008752|UniProtKB=H2QC90	Uncharacterized protein	ISS	9427245	PubMed	PTHR10574:SF365	NETRIN-1
P02757	O-antigen biosynthesis	P03045	dTDP-glucose 4,6-dehydratase	LEPIN|EnsemblGenome=LA_1606|UniProtKB=Q8F5R1	Nucleoside-diphosphate-sugar epimerase	ISS			PTHR43000:SF2	SUBFAMILY NOT NAMED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05943	GRK2	MOUSE|MGI=MGI=87940|UniProtKB=Q99MK8	Beta-adrenergic receptor kinase 1	RCA	10852916	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	HUMAN|HGNC=288|UniProtKB=P13945	Beta-3 adrenergic receptor	IDA	11943840	PubMed	PTHR24248:SF3	BETA-3 ADRENERGIC RECEPTOR
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01189	PTEN	XENTR|Xenbase=XB-GENE-491433|UniProtKB=B1H2U0	Pten protein	ISS	10555148	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P06587	Nicotine pharmacodynamics pathway	P06614	TH	MACMU|Ensembl=ENSMMUG00000003912|UniProtKB=F6ZV38	Uncharacterized protein	ISS	12814656	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	RAT|RGD=621516|UniProtKB=G3V6P8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00944	Actin	BOVIN|Gene=ACTG2|UniProtKB=Q5E9B5	Actin, gamma-enteric smooth muscle	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	ORYSJ|EnsemblGenome=OS06G0699400|UniProtKB=Q5Z859	Mitogen-activated protein kinase 4	TAS			PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00034	Integrin signalling pathway	P00931	Integrin beta	MOUSE|MGI=MGI=96611|UniProtKB=P11835	Integrin beta-2	IDA	3487386	PubMed	PTHR10082:SF15	INTEGRIN BETA-2
P00034	Integrin signalling pathway	P00920	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00020	FAS signaling pathway	P00615	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00054	Toll receptor signaling pathway	P01373	CD14	MOUSE|MGI=MGI=88318|UniProtKB=P10810	Monocyte differentiation antigen CD14	ISS			PTHR10630:SF3	MONOCYTE DIFFERENTIATION ANTIGEN CD14
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00047	PDGF signaling pathway	P01157	MAPKAPK2	BOVIN|Ensembl=ENSBTAG00000038107|UniProtKB=F1MCX5	Uncharacterized protein	ISS	8262198	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2051|UniProtKB=P28647	Adenosine receptor A3	ISS	12515326	PubMed	PTHR24246:SF2	ADENOSINE RECEPTOR A3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00010	B cell activation	P00371	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000012922|UniProtKB=H2QJF2	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00038	JAK/STAT signaling pathway	P01027	STAT	BOVIN|Gene=STAT3|UniProtKB=P61635	Signal transducer and activator of transcription 3	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000014976|UniProtKB=H2R892	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P06216	SCW signaling pathway	P06326	SCW	DROME|FlyBase=FBgn0005590|UniProtKB=P54631	Protein screw	IEA	http://flybase.org/reports/FBgn0005590.html	Website	PTHR11848:SF54	PROTEIN 60A-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CAEEL|WormBase=WBGene00000063|UniProtKB=P0DM41	Actin-1	IC	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=1762|UniProtKB=P22223	Cadherin-3	IDA	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IDA	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	XENTR|Xenbase=XB-GENE-491571|UniProtKB=F6WW07	Uncharacterized protein (Fragment)	ISS	12473693	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IDA	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00036	Interleukin signaling pathway	P00968	Ikk	HUMAN|HGNC=1974|UniProtKB=O15111	Inhibitor of nuclear factor kappa-B kinase subunit alpha	IC	9346484	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	TAS	10207617	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00577	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000009085|UniProtKB=H2RDQ2	Uncharacterized protein	ISS	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00049	Parkinson disease	P01227	20S proteasome	ARATH|TAIR=AT5G40580|UniProtKB=Q7DLS1	Proteasome subunit beta type-7-B	TAS	12859888	PubMed	PTHR11599:SF44	AT05866P-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00053	T cell activation	P01332	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00055	Transcription regulation by bZIP transcription factor	P01395	TFIIE	DROME|FlyBase=FBgn0015829|UniProtKB=O96881	Transcription initiation factor IIE subunit beta	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P00048	PI3 kinase pathway	P01185	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00830	Lipoxygenase	PANTR|Ensembl=ENSPTRG00000008653|UniProtKB=H2QC17	Uncharacterized protein	ISS	12432925	PubMed	PTHR11771:SF4	ARACHIDONATE 12-LIPOXYGENASE, 12S-TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	XENTR|Xenbase=XB-GENE-6067221|UniProtKB=F6Z0J4	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04393	Ras Pathway	P04558	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00807	Actin	MACMU|Ensembl=ENSMMUG00000009341|UniProtKB=F6UA54	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00021	FGF signaling pathway	P00648	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	IGI	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	CHLTR|EnsemblGenome=CT_500|UniProtKB=O84508	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00048	PI3 kinase pathway	P01206	14-3-3	ORNAN|Ensembl=ENSOANG00000007305|UniProtKB=F6XW91	Uncharacterized protein	ISS	92362864	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00005	Angiogenesis	P00222	VEGFR-2	BOVIN|Ensembl=ENSBTAG00000000782|UniProtKB=F1MWF1	Uncharacterized protein	ISS	11824379	PubMed	PTHR24416:SF45	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	TAS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00054	Toll receptor signaling pathway	P01341	Elk1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	ISS	11151091	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00034	Integrin signalling pathway	P00906	Rap1	TAKRU|Ensembl=ENSTRUG00000006464|UniProtKB=H2STT5	Uncharacterized protein	ISS	8576107	PubMed	PTHR24070:SF382	RAS-RELATED PROTEIN RAP-1B
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CANLF|Ensembl=ENSCAFG00000008756|UniProtKB=F2Z4N8	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	RCA	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=3025|UniProtKB=P21917	D(4) dopamine receptor	IDA	1319557	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P04393	Ras Pathway	P04566	Stat 1/3	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	RAT|RGD=3238|UniProtKB=P01179	Oxytocin-neurophysin 1	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	TAS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00004	Alzheimer disease-presenilin pathway	P00145	CD44	MACMU|Ensembl=ENSMMUG00000004327|UniProtKB=F6ZDZ8	Uncharacterized protein	ISS	12223485	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P05915	Opioid proenkephalin pathway	P05994	G-protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00047	PDGF signaling pathway	P01150	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	11035810	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	DAPPU|EnsemblGenome=DAPPUDRAFT_442795|UniProtKB=E9H5Z2	Calmodulin	ISS	3885394	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00005	Angiogenesis	P00243	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	ISS	14698601	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DANRE|ZFIN=ZDB-GENE-030131-1229|UniProtKB=Q6DHS1	Actin, alpha 2, smooth muscle, aorta	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IC	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TRIVA|Gene=TVAG_090470|UniProtKB=A2FA04	Actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000005766|UniProtKB=F6W1H1	Uncharacterized protein	ISS	8120095	PubMed	PTHR43912:SF7	PROTOCADHERIN-20
P00053	T cell activation	P01312	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IDA	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	RAT|RGD=2738|UniProtKB=Q00960	Glutamate receptor ionotropic, NMDA 2B	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00887	IRS 1-4	MACMU|Ensembl=ENSMMUG00000019467|UniProtKB=F6SUL3	Uncharacterized protein	ISS	15110093	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00021	FGF signaling pathway	P00628	JNK1-3	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS			PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00029	Huntington disease	P00798	Clathrin	BOVIN|Ensembl=ENSBTAG00000001137|UniProtKB=P04973	Clathrin light chain A	IDA	11889126	PubMed	PTHR10639:SF1	CLATHRIN LIGHT CHAIN A
P04398	p53 pathway feedback loops 2	P04663	Mdm2	HUMAN|HGNC=6973|UniProtKB=Q00987	E3 ubiquitin-protein ligase Mdm2	IGI	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00021	FGF signaling pathway	P00643	Raf-1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IGI	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01456	beta-arrestin	BOVIN|Gene=ARRB2|UniProtKB=P32120	Beta-arrestin-2	IDA	4757780	gi	PTHR11792:SF20	BETA-ARRESTIN-2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01150	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	SCHMA|EnsemblGenome=Smp_202970|UniProtKB=G4VLN1	Putative uncharacterized protein Smp_202970	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	MONDO|Ensembl=ENSMODG00000005337|UniProtKB=F7CHT9	Uncharacterized protein	ISS	9727008	PubMed	PTHR10410:SF5	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 14
P00034	Integrin signalling pathway	P00907	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	IDA	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00048	PI3 kinase pathway	P01182	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	MOUSE|MGI=MGI=88548|UniProtKB=P67871	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00009	Axon guidance mediated by netrin	P00357	Netrin	HUMAN|HGNC=23319|UniProtKB=Q9Y2I2	Netrin-G1	ISS			PTHR10574:SF28	NETRIN-G1
P00006	Apoptosis signaling pathway	P00269	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01456	beta-arrestin	MACMU|Ensembl=ENSMMUG00000017654|UniProtKB=F6UI32	Beta-arrestin-2 isoform 1	ISS	11742073	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04393	Ras Pathway	P04543	MEKK1/4	MOUSE|MGI=MGI=1346875|UniProtKB=O08648	Mitogen-activated protein kinase kinase kinase 4	IDA	10207617	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00018	EGF receptor signaling pathway	P00547	PP2A	MACMU|Ensembl=ENSMMUG00000004873|UniProtKB=F7ANY9	Uncharacterized protein	ISS	12110603	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P06587	Nicotine pharmacodynamics pathway	P06590	GNG	PANTR|Ensembl=ENSPTRG00000006342|UniProtKB=H2Q8A8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P06959	CCKR signaling map	G06990	MOB1	HUMAN|HGNC=16015|UniProtKB=Q9H8S9	MOB kinase activator 1A	RCA	10409110	PubMed	PTHR22599:SF30	MOB KINASE ACTIVATOR 1A
P00029	Huntington disease	P00788	Calpain	RAT|RGD=2267|UniProtKB=P97571	Calpain-1 catalytic subunit	IDA	11675509	PubMed	PTHR10183:SF284	CALPAIN-1 CATALYTIC SUBUNIT
P00049	Parkinson disease	P01219	SAPK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00048	PI3 kinase pathway	P01177	P110ACT	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	IGI	1171954	gi	PTHR10048:SF14	PI-3 KINASE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	ORYSJ|EnsemblGenome=OS06G0699400|UniProtKB=Q5Z859	Mitogen-activated protein kinase 4	ISS			PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2851|UniProtKB=P35364	5-hydroxytryptamine receptor 5A	IDA	12181435	PubMed	PTHR24247:SF108	5-HYDROXYTRYPTAMINE RECEPTOR 5A
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TAKRU|Ensembl=ENSTRUG00000007989|UniProtKB=P68140	Actin, alpha skeletal muscle A	ISS	10974003	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00036	Interleukin signaling pathway	P00964	p90RSK	HUMAN|HGNC=10435|UniProtKB=Q9UK32	Ribosomal protein S6 kinase alpha-6	IC	15632195	PubMed	PTHR24351:SF98	RIBOSOMAL PROTEIN S6 KINASE ALPHA-6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	HUMAN|HGNC=236|UniProtKB=O95622	Adenylate cyclase type 5	IC	2491850	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00049	Parkinson disease	P01230	Src kinase	HUMAN|HGNC=4037|UniProtKB=P06241	Tyrosine-protein kinase Fyn	IDA	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	RCA	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P05916	Opioid prodynorphin pathway	P05999	provasopressin	PANTR|Ensembl=ENSPTRG00000013189|UniProtKB=H2QJV1	Uncharacterized protein	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P04397	p53 pathway by glucose deprivation	P04641	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00255	Notch	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	1764995	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00006	Apoptosis signaling pathway	P00261	Bok	BOVIN|Ensembl=ENSBTAG00000008711|UniProtKB=A6H6W7	BOK protein	ISS	9356461	PubMed	PTHR11256:SF48	BCL-2-RELATED OVARIAN KILLER PROTEIN
P00034	Integrin signalling pathway	P00931	Integrin beta	MACMU|Ensembl=ENSMMUG00000003289|UniProtKB=F7FG54	Integrin beta	ISS	20069419	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00019	Endothelin signaling pathway	P00570	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04568	MKK3/6	MACMU|Ensembl=ENSMMUG00000001051|UniProtKB=F6QNB5	Dual specificity mitogen-activated protein kinase kinase 6	RCA			PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00046	Oxidative stress response	P01131	MKP5	BOVIN|Ensembl=ENSBTAG00000044208|UniProtKB=F1MM08	Dual specificity protein phosphatase	ISS			PTHR10159:SF111	DUAL SPECIFICITY PROTEIN PHOSPHATASE 4
P04398	p53 pathway feedback loops 2	P04668	p53	MOUSE|MGI=MGI=98834|UniProtKB=P02340	Cellular tumor antigen p53	TAS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00021	FGF signaling pathway	P00626	Spry	DANRE|ZFIN=ZDB-GENE-010803-2|UniProtKB=F1QZW4	Uncharacterized protein	IGI	21384945	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P04398	p53 pathway feedback loops 2	P04657	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IC	15572354	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00006	Apoptosis signaling pathway	P00269	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P06214	GBB signaling pathway	P06297	PDP	DROME|FlyBase=FBgn0029958|UniProtKB=Q9W3Q1	GM14286p	IDA	16510868	PubMed	PTHR13832:SF503	PYRUVATE DEHYDROGENASE  ACETYL-TRANSFERRING  -PHOSPHATASE 1, MITOCHONDRIAL
P00048	PI3 kinase pathway	P01197	Caspase-9	HUMAN|HGNC=1511|UniProtKB=P55211	Caspase-9	ISS	11440972	PubMed	PTHR10454:SF157	CASPASE-9
P00019	Endothelin signaling pathway	P00591	PLCbeta	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	BOVIN|Ensembl=ENSBTAG00000018445|UniProtKB=E1BK87	Uncharacterized protein	ISS	11319238	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	CAEEL|WormBase=WBGene00003774|UniProtKB=G5EGQ9	NMDA class glutamate Receptor	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04585	TRH	CHICK|Ensembl=ENSGALG00000002550|UniProtKB=O57340	Thyrotropin subunit beta	ISS			PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P00034	Integrin signalling pathway	P00935	ILK	BOVIN|Gene=ILK|UniProtKB=Q3SWY2	Integrin-linked protein kinase	ISS			PTHR44344:SF1	INTEGRIN-LINKED PROTEIN KINASE
P04393	Ras Pathway	P04556	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IDA	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00223	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00590	IP3 R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	IGI	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00021	FGF signaling pathway	P00642	MEK1-2	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00047	PDGF signaling pathway	P01161	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00029	Huntington disease	P00777	CBP	ARATH|TAIR=AT1G55970|UniProtKB=Q9LG11	Histone acetyltransferase HAC4	IDA	10664585	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P05730	Endogenous cannabinoid signaling	P05748	mGluR	RAT|RGD=2746|UniProtKB=P31424	Metabotropic glutamate receptor 5	ISS	14614461	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	IDA	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00053	T cell activation	P01303	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	8479536	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	HUMAN|HGNC=234|UniProtKB=O60266	Adenylate cyclase type 3	IDA	12623444	PubMed	PTHR11920:SF291	ADENYLATE CYCLASE TYPE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02777	Succinate to proprionate conversion	P03161	Methylmalonyl-CoA mutase	BOVIN|Gene=MUT|UniProtKB=Q9GK13	Methylmalonyl-CoA mutase, mitochondrial	ISS			PTHR42710:SF1	METHYLMALONYL-COA MUTASE, MITOCHONDRIAL
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	RAT|RGD=621516|UniProtKB=G3V6P8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00049	Parkinson disease	P01208	Hsp70	DANRE|ZFIN=ZDB-GENE-050321-1|UniProtKB=B0S610	Novel protein similar to heat shock cognate 70-kd protein	IDA	12150907	PubMed	PTHR19375:SF256	HSP70 PROTEIN-RELATED
P04393	Ras Pathway	P04559	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	IDA	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00052	TGF-beta signaling pathway	P01284	JNK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	TAS	7600581	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00941	Integrin alpha	MOUSE|MGI=MGI=96607|UniProtKB=P05555	Integrin alpha-M	IPI	12060491	PubMed	PTHR23220:SF120	INTEGRIN ALPHA-M
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00018	EGF receptor signaling pathway	P00562	p38	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00021	FGF signaling pathway	P00644	p38	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04393	Ras Pathway	P04547	Ras	CHICK|Ensembl=ENSGALG00000014033|UniProtKB=E1BTS2	Uncharacterized protein	ISS	3023884	PubMed	PTHR24070:SF186	GTPASE KRAS
P00023	General transcription regulation	P00660	RNA Polymerase II	ARATH|TAIR=AT3G57080|UniProtKB=Q9M1J2	DNA-directed RNA polymerase V subunit 5A	ISS	11313498	gi	PTHR10535:SF2	DNA-DIRECTED RNA POLYMERASE V SUBUNIT 5A-RELATED
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IC	10747026	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00019	Endothelin signaling pathway	P00566	ERK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	NAS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00009	Axon guidance mediated by netrin	P00366	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P06959	CCKR signaling map	P07074	MAP2K4	HUMAN|HGNC=6844|UniProtKB=P45985	Dual specificity mitogen-activated protein kinase kinase 4	RCA	12239223	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IDA	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01412	HSP27	CIOIN|Ensembl=ENSCING00000000618|UniProtKB=F6RRK4	Uncharacterized protein	ISS			PTHR11527:SF243	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	RAT|RGD=1304632|UniProtKB=D3ZS84	Protein Socs6	ISS	12645661	PubMed	PTHR44562:SF1	SUPPRESSOR OF CYTOKINE SIGNALING 6
P02724	Alanine biosynthesis	P02815	Branched chain amino acid aminotransferase	METAC|EnsemblGenome=MA_4349|UniProtKB=Q8TI08	Branched chain amino acid aminotransferase	ISS			PTHR42743:SF3	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE-LIKE PROTEIN 1-RELATED
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	DANRE|ZFIN=ZDB-GENE-010705-1|UniProtKB=Q90Z40	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00057	Wnt signaling pathway	P01471	alpha-catenin	MOUSE|MGI=MGI=88275|UniProtKB=Q61301	Catenin alpha-2	IDA	9362521	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	ANOGA|EnsemblGenome=AGAP009660|UniProtKB=Q7Q1R6	AGAP009660-PA	ISS			PTHR23359:SF145	GTP:AMP PHOSPHOTRANSFERASE, MITOCHONDRIAL
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00057	Wnt signaling pathway	P01429	Axin	MACMU|Ensembl=ENSMMUG00000000605|UniProtKB=F6Y8V8	Uncharacterized protein	ISS	12549854	PubMed	PTHR10845:SF11	AXIN-1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008422|UniProtKB=F6VUT7	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00922	Collagen	MOUSE|MGI=MGI=88456|UniProtKB=Q63ZW6	Col4a5 protein	IDA	10778855	PubMed	PTHR24023:SF847	COLLAGEN ALPHA-5 IV  CHAIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00052	TGF-beta signaling pathway	P01292	RSmads	MONDO|Ensembl=ENSMODG00000015152|UniProtKB=F7CFQ6	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF36	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=620797|UniProtKB=P49218	Melatonin receptor type 1A (Fragment)	ISS			PTHR43962:SF2	MELATONIN RECEPTOR TYPE 1A
P00012	Cadherin signaling pathway	P00475	Frizzled	HUMAN|HGNC=4039|UniProtKB=Q9ULW2	Frizzled-10	IDA	8717036	PubMed	PTHR11309:SF86	FRIZZLED-10
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	CAEEL|WormBase=WBGene00004860|UniProtKB=Q09488	Serine/threonine-protein kinase sma-6	TAS	11252892	PubMed	PTHR23255:SF68	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	BOVIN|Ensembl=ENSBTAG00000037985|UniProtKB=F1MCK3	Muscarinic acetylcholine receptor	ISS	10069496	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P04380	Cortocotropin releasing factor receptor signaling pathway	G04671	proopiomelanocortin	BOVIN|Ensembl=ENSBTAG00000007897|UniProtKB=P01190	Pro-opiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00021	FGF signaling pathway	P00624	14-3-3	CAEEL|WormBase=WBGene00001502|UniProtKB=Q20655	14-3-3-like protein 2	ISS	10407019	PubMed	PTHR18860:SF13	14-3-3 PROTEIN ZETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	MOUSE|MGI=MGI=3605069|UniProtKB=Q6PHB0	Interleukin-20 receptor subunit alpha	ISS			PTHR20859:SF21	INTERLEUKIN-20 RECEPTOR SUBUNIT ALPHA
P00045	Notch signaling pathway	P01105	TACE	MOUSE|MGI=MGI=109548|UniProtKB=O35598	Disintegrin and metalloproteinase domain-containing protein 10	TAS			PTHR11905:SF4	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 10
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	RAT|RGD=2026|UniProtKB=P68035	Actin, alpha cardiac muscle 1	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	7565716	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P04393	Ras Pathway	P04546	GSK3	HUMAN|HGNC=4616|UniProtKB=P49840	Glycogen synthase kinase-3 alpha	IDA	12086949	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P05913	Enkephalin release	P05972	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01153	GSK3	HUMAN|HGNC=4616|UniProtKB=P49840	Glycogen synthase kinase-3 alpha	ISS	21361340	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00059	p53 pathway	P04633	P110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00386	Calcineurin	NEUCR|EnsemblGenome=EFNCRG00000003474|UniProtKB=Q05681	Serine/threonine-protein phosphatase 2B catalytic subunit	IDA	7532676	PubMed	PTHR11668:SF118	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01174	Rho	HUMAN|HGNC=26099|UniProtKB=A1A4S6	Rho GTPase-activating protein 10	ISS	8649427	PubMed	PTHR12552:SF5	RHO GTPASE-ACTIVATING PROTEIN 10
P06959	CCKR signaling map	P07117	BCL2L1	HUMAN|HGNC=992|UniProtKB=Q07817	Bcl-2-like protein 1	RCA	18565785	PubMed	PTHR11256:SF12	BCL-2-LIKE PROTEIN 1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00059	p53 pathway	P04630	PP2A	ANOGA|EnsemblGenome=AGAP010172|UniProtKB=Q7PD38	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00373	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05916	Opioid prodynorphin pathway	P06000	vasopressin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00029	Huntington disease	P00796	Kainate receptor	XENTR|Xenbase=XB-GENE-957124|UniProtKB=F7BDN8	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00056	VEGF signaling pathway	P01407	Erk	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00190	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	8270251	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00018	EGF receptor signaling pathway	P00561	STAT	MOUSE|MGI=MGI=103039|UniProtKB=Q9WVL2	Signal transducer and activator of transcription 2	IGI	11786546	PubMed	PTHR11801:SF41	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	MONBE|Gene=11217|UniProtKB=A9V8J8	Predicted protein	ISS	3885394	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	IDA	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00034	Integrin signalling pathway	P00907	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00007	Axon guidance mediated by semaphorins	P00331	PAK	MACMU|Ensembl=ENSMMUG00000001387|UniProtKB=F7D0B4	Uncharacterized protein	ISS	14580336	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00010	B cell activation	P00388	PLC gamma2	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00010	B cell activation	P00385	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	ISS	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00029	Huntington disease	P00774	Dynein complex	CANLF|Ensembl=ENSCAFG00000010318|UniProtKB=E2RK00	Uncharacterized protein	ISS	9454836	PubMed	PTHR11886:SF52	DYNEIN LIGHT CHAIN 1, CYTOPLASMIC
P00020	FAS signaling pathway	P00600	PARP	MOUSE|MGI=MGI=1340806|UniProtKB=P11103	Poly [ADP-ribose] polymerase 1	TAS	12101391	PubMed	PTHR10459:SF80	POLY  ADP-RIBOSE  POLYMERASE 1
P00047	PDGF signaling pathway	P01159	SOS	DROME|FlyBase=FBgn0001965|UniProtKB=P26675	Protein son of sevenless	ISS	476780	gi	PTHR23113:SF99	PROTEIN SON OF SEVENLESS
P00019	Endothelin signaling pathway	P00566	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	20331588	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00023	General transcription regulation	P00660	RNA Polymerase II	HUMAN|HGNC=9193|UniProtKB=P61218	DNA-directed RNA polymerases I, II, and III subunit RPABC2	ISS	415387	gi	PTHR10773:SF12	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	IDA	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00018	EGF receptor signaling pathway	P00546	GAP	BOVIN|Ensembl=ENSBTAG00000011829|UniProtKB=F1MHW1	Uncharacterized protein	ISS	8982875	PubMed	PTHR10194:SF60	NEUROFIBROMIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06823	DUSP1	MOUSE|MGI=MGI=105120|UniProtKB=P28563	Dual specificity protein phosphatase 1	RCA	11856337	PubMed	PTHR10159:SF309	DUAL SPECIFICITY PROTEIN PHOSPHATASE 1
P00047	PDGF signaling pathway	P01161	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00587	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01438	PP2A	MACMU|Ensembl=ENSMMUG00000019771|UniProtKB=F7APV7	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform 1	ISS	12110603	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00047	PDGF signaling pathway	P01173	STAT	HUMAN|HGNC=11362|UniProtKB=P42224	Signal transducer and activator of transcription 1-alpha/beta	ISS	10207096	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P05734	Synaptic vesicle trafficking	P05779	Synaptobrevin	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00018	EGF receptor signaling pathway	P00556	PLCgamma	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00006	Apoptosis signaling pathway	P00260	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00640	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IGI	12660731	PubMed	PTHR10048:SF14	PI-3 KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000000289|UniProtKB=F7A9T0	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00048	PI3 kinase pathway	P01176	JAK	PANTR|Ensembl=ENSPTRG00000020744|UniProtKB=H2QWZ4	Tyrosine-protein kinase	ISS	22482294	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00018	EGF receptor signaling pathway	P00558	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CAEEL|WormBase=WBGene00001187|UniProtKB=Q8MQA1	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00051	TCA cycle	P01274	Succinyl CoA Synthetase	TRIVA|Gene=TVAG_047890|UniProtKB=Q65ZG5	Adhesin protein AP33-2	IDA	7808480	PubMed	PTHR11117:SF2	SUCCINYL-COA LIGASE  ADP/GDP-FORMING  SUBUNIT ALPHA, MITOCHONDRIAL
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	XENTR|GeneID=394982|UniProtKB=P20399	Actin, alpha cardiac muscle 2	ISS	14684598	PubMed	PTHR11937:SF263	ACTIN
P02738	De novo purine biosynthesis	P02909	GDP reductase	ORYSJ|EnsemblGenome=OS06G0168600|UniProtKB=Q5VRF5	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00053	T cell activation	P01325	LAT	HUMAN|HGNC=18874|UniProtKB=O43561	Linker for activation of T-cells family member 1	IPI	9489702	PubMed	PTHR15586:SF0	LINKER FOR ACTIVATION OF T-CELLS FAMILY MEMBER 1
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	PANTR|Ensembl=ENSPTRG00000006510|UniProtKB=H2Q8K1	Presenilin	ISS	12736250	PubMed	PTHR10202:SF18	PRESENILIN-1
P04397	p53 pathway by glucose deprivation	P04641	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	NEUCR|EnsemblGenome=EFNCRG00000003822|UniProtKB=Q1K7J3	Syntaxin 2	IC			PTHR19957:SF147	SUBFAMILY NOT NAMED
P02759	Pyridoxal-5-phosphate biosynthesis	P03062	1-Deoxyxylulose-5-phosphate synthase	ARATH|TAIR=AT4G15560|UniProtKB=Q38854	1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic	ISS			PTHR43322:SF5	1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE 1-RELATED
P00005	Angiogenesis	P00256	PLC-gamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00029	Huntington disease	P00787	MAPKK4	PANTR|Ensembl=ENSPTRG00000008783|UniProtKB=H2QCA7	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	MOUSE|MGI=MGI=106677|UniProtKB=Q8BRU6	Synaptic vesicular amine transporter	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04393	Ras Pathway	P04559	Rac	ENTHI|EnsemblGenome=EHI_070730|UniProtKB=C4M5T0	Rho family GTPase	ISS	12932731	PubMed	PTHR24072:SF117	RHO-RELATED PROTEIN RACC
P00047	PDGF signaling pathway	P01143	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	PANTR|Ensembl=ENSPTRG00000007489|UniProtKB=H2QA49	Tyrosine-protein kinase receptor	ISS	2877871	PubMed	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P04393	Ras Pathway	P04574	PLD	BOVIN|Gene=PLD2|UniProtKB=Q0V8L6	Phospholipase D2	ISS	15030398	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Ensembl=ENSPTRG00000000543|UniProtKB=H2PYN8	Uncharacterized protein	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00021	FGF signaling pathway	P00627	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00019	Endothelin signaling pathway	P00591	PLCbeta	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT3G59790|UniProtKB=Q9M1Z5	Mitogen-activated protein kinase 10	ISS	10851062	PubMed	PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TRIAD|EnsemblGenome=TriadG56111|UniProtKB=B3RX77	Non-muscle actin 6.2	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	BOVIN|Gene=ACTG2|UniProtKB=Q5E9B5	Actin, gamma-enteric smooth muscle	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00053	T cell activation	P01324	rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12912997	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P04393	Ras Pathway	P04565	MKK4/7	HUMAN|HGNC=6844|UniProtKB=P45985	Dual specificity mitogen-activated protein kinase kinase 4	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00021	FGF signaling pathway	P00642	MEK1-2	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IGI	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02727	Androgen/estrogene/progesterone biosynthesis	P02829	Cholesterol acyltransferase	MOUSE|MGI=MGI=104665|UniProtKB=Q61263	Sterol O-acyltransferase 1	IMP	8662991	PubMed	PTHR10408:SF6	STEROL O-ACYLTRANSFERASE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	MOUSE|MGI=MGI=103249|UniProtKB=P62204	Calmodulin	ISS	9753452	PubMed	PTHR23050:SF311	CALMODULIN
P00056	VEGF signaling pathway	P01409	cPLA2	ORNAN|Ensembl=ENSOANG00000001027|UniProtKB=F6QDY0	Phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	RAT|RGD=1310749|UniProtKB=D3Z9H7	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	ISS	12787506	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00056	VEGF signaling pathway	P01414	PLC-gamma	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00053	T cell activation	P01300	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00965	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	BOVIN|Ensembl=ENSBTAG00000020887|UniProtKB=F1MP22	Uncharacterized protein	ISS	11976940	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	TAKRU|Ensembl=ENSTRUG00000007962|UniProtKB=Q804S3	Bone morphogenetic protein 2	ISS	9759503	PubMed	PTHR11848:SF229	BONE MORPHOGENETIC PROTEIN 2
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	BOVIN|Ensembl=ENSBTAG00000040329|UniProtKB=F1MMU1	Uncharacterized protein	ISS	11701344	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P02738	De novo purine biosynthesis	P02902	ADP reductase	RAT|RGD=1598310|UniProtKB=Q4KLN6	Ribonucleoside-diphosphate reductase subunit M2	ISS			PTHR23409:SF20	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00034	Integrin signalling pathway	P00920	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ORYSJ|EnsemblGenome=OS02G0148100|UniProtKB=Q6Z437	Mitogen-activated protein kinase 3	ISS	7341300	gi	PTHR24055:SF216	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=4598|UniProtKB=O15303	Metabotropic glutamate receptor 6	IDA	9407094	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04494	TSC2	HUMAN|HGNC=12363|UniProtKB=P49815	Tuberin	ISS	15249583	PubMed	PTHR10063:SF0	TUBERIN
P00059	p53 pathway	P01486	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00898	FKHR	PANTR|Ensembl=ENSPTRG00000018476|UniProtKB=H2R710	Forkhead box O3	ISS	10102273	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MOUSE|MGI=MGI=104589|UniProtKB=P63268	Actin, gamma-enteric smooth muscle	IC	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00053	T cell activation	P01332	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00310	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	IC	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01211	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00005	Angiogenesis	P00223	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	BOVIN|Ensembl=ENSBTAG00000000820|UniProtKB=Q5E9F0	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	ISS	2122451	PubMed	PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04541	p90RSK	MACMU|Ensembl=ENSMMUG00000022111|UniProtKB=F7H7W3	Ribosomal protein S6 kinase	ISS	12213813	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00013	Cell cycle	P00480	Proteasome	MOUSE|MGI=MGI=1914247|UniProtKB=Q9D8W5	26S proteasome non-ATPase regulatory subunit 12	ISS	9426256	PubMed	PTHR10855:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04377	Beta1 adrenergic receptor signaling pathway	P04433	Beta1	RAT|RGD=2059|UniProtKB=P18090	Beta-1 adrenergic receptor	ISS	12063255	PubMed	PTHR24248:SF54	BETA-1 ADRENERGIC RECEPTOR
P00049	Parkinson disease	P01236	Casein kinase II	HUMAN|HGNC=2460|UniProtKB=P67870	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	TAS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MONDO|Ensembl=ENSMODG00000001807|UniProtKB=F6Y7R9	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	HUMAN|HGNC=10935|UniProtKB=Q05940	Synaptic vesicular amine transporter	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	BOVIN|Ensembl=ENSBTAG00000006159|UniProtKB=E1BNE9	G protein-activated inward rectifier potassium channel 1	ISS			PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00010	B cell activation	P00380	fos	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	TAS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BOVIN|Ensembl=ENSBTAG00000000820|UniProtKB=Q5E9F0	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	ISS			PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P00038	JAK/STAT signaling pathway	P01027	STAT	MACMU|Ensembl=ENSMMUG00000010705|UniProtKB=F7G8V4	Signal transducer and activator of transcription	ISS	7514531	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00049	Parkinson disease	P01242	Casein kinase I	RAT|RGD=71098|UniProtKB=P97633	Casein kinase I isoform alpha	IDA	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00019	Endothelin signaling pathway	P00590	IP3 R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	PANTR|Ensembl=ENSPTRG00000010617|UniProtKB=H2QFL8	Notch 3	ISS	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00023	General transcription regulation	P00658	TBP-associated factors	PANTR|Ensembl=ENSPTRG00000022053|UniProtKB=H2R4N5	Uncharacterized protein	ISS			PTHR12595:SF3	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 9B
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	CHICK|Ensembl=ENSGALG00000014033|UniProtKB=E1BTS2	Uncharacterized protein	ISS	3023884	PubMed	PTHR24070:SF186	GTPASE KRAS
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01242	Casein kinase I	BOVIN|Ensembl=ENSBTAG00000019986|UniProtKB=P35508	Casein kinase I isoform delta	ISS	10617630	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	BOVIN|Ensembl=ENSBTAG00000008059|UniProtKB=P41984	Muscarinic acetylcholine receptor M3	IDA	12915051	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00983	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00951	Jnk	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00006	Apoptosis signaling pathway	P00279	endoG	RAT|RGD=1310763|UniProtKB=Q3V5X8	Endonuclease G	ISS	9324313	PubMed	PTHR13966:SF5	ENDONUCLEASE G, MITOCHONDRIAL
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P06959	CCKR signaling map	P07188	RHOA-GTP	HUMAN|HGNC=667|UniProtKB=P61586	Transforming protein RhoA	RCA	18565785	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	RAT|RGD=620577|UniProtKB=Q62636	Ras-related protein Rap-1b	IDA	1904317	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00050	Plasminogen activating cascade	P01253	Fibrin	RAT|RGD=2604|UniProtKB=P14480	Fibrinogen beta chain	ISS	1706801	gi	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01408	Akt/PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00586	Gq	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00006	Apoptosis signaling pathway	P00309	Smac/Diablo	CANLF|Ensembl=ENSCAFG00000007933|UniProtKB=A1DZY5	Mitochondrial diablo-like protein	ISS			PTHR32247:SF3	DIABLO HOMOLOG, MITOCHONDRIAL
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	MONDO|Ensembl=ENSMODG00000018321|UniProtKB=Q6YNX4	Glycoprotein hormones alpha chain	ISS	15927770	PubMed	PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P00047	PDGF signaling pathway	P01148	Grb2	DANRE|ZFIN=ZDB-GENE-040426-1975|UniProtKB=Q6PC73	Growth factor receptor-bound protein 2	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	TAS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=98959|UniProtKB=P22726	Protein Wnt-5b	IDA	11266476	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P05731	GABA-B receptor II signaling	P05755	Gbeta	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MOUSE|MGI=MGI=109248|UniProtKB=Q920H4	Muscarinic acetylcholine receptor M5	TAS	11166329	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000008430|UniProtKB=F6VB97	Uncharacterized protein	ISS			PTHR11824:SF8	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-3
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00059	p53 pathway	P01480	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	ECOLI|EcoGene=EG20257|UniProtKB=P39452	Ribonucleoside-diphosphate reductase 2 subunit alpha	ISS			PTHR11573:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IDA	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	MACMU|Ensembl=ENSMMUG00000016675|UniProtKB=F6VTB5	Uncharacterized protein	ISS	11319238	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00022	General transcription by RNA polymerase I	P00649	TAF-IC	MACMU|Ensembl=ENSMMUG00000008569|UniProtKB=F6UPU0	Uncharacterized protein	ISS	20355009	PubMed	PTHR15319:SF1	TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT C
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00005	Angiogenesis	P00238	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00562	p38	DROME|FlyBase=FBgn0015765|UniProtKB=O62618	Mitogen-activated protein kinase 14A	IGI	11274345	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00046	Oxidative stress response	P01135	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CANLF|Ensembl=ENSCAFG00000028848|UniProtKB=J9NRZ4	Uncharacterized protein	ISS	10664585	PubMed	PTHR11462:SF37	TRANSCRIPTION FACTOR JUN-B
P00034	Integrin signalling pathway	P00907	ERK	BOVIN|Ensembl=ENSBTAG00000013790|UniProtKB=E1B847	Uncharacterized protein	ISS			PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00030	Hypoxia response via HIF activation	P00821	Prolyl Hydroxylase	PANTR|Ensembl=ENSPTRG00000006250|UniProtKB=H2Q856	Egl nine homolog 3	ISS	12912907	PubMed	PTHR12907:SF5	EGL NINE HOMOLOG 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00774	Dynein complex	MOUSE|MGI=MGI=107736|UniProtKB=Q45VK7	Cytoplasmic dynein 2 heavy chain 1	ISS	9454836	PubMed	PTHR10676:SF352	CYTOPLASMIC DYNEIN 2 HEAVY CHAIN 1
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	RAT|RGD=621516|UniProtKB=G3V6P8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00021	FGF signaling pathway	P00627	ERK1-2	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01199	Galpha	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	ORYSJ|EnsemblGenome=OS02G0148100|UniProtKB=Q6Z437	Mitogen-activated protein kinase 3	TAS			PTHR24055:SF216	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000017387|UniProtKB=E2RLD1	Uncharacterized protein	ISS	129387	gi	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	MONDO|Ensembl=ENSMODG00000019001|UniProtKB=F7CP86	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00632	Akt	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	IGI	7876156	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00036	Interleukin signaling pathway	P00974	Receptor subunit beta	PANTR|Gene=CXCR2|UniProtKB=Q28807	C-X-C chemokine receptor type 2 (Fragment)	ISS	4504683	gi	PTHR10489:SF689	C-X-C CHEMOKINE RECEPTOR TYPE 2
P00010	B cell activation	P00369	MEKK	HUMAN|HGNC=6854|UniProtKB=Q9Y2U5	Mitogen-activated protein kinase kinase kinase 2	IDA	11730323	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MONDO|Ensembl=ENSMODG00000016960|UniProtKB=F6V5G0	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	8787761	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8687|UniProtKB=Q9Y5E7	Protocadherin beta-2	IDA	8120095	PubMed	PTHR24028:SF77	PROTOCADHERIN BETA-2
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00059	p53 pathway	G04701	PML	PANTR|Ensembl=ENSPTRG00000007266|UniProtKB=Q15JE1	Promyelocytic leukemia	ISS	12810724	PubMed	PTHR45211:SF1	PROTEIN PML
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	MACMU|Ensembl=ENSMMUG00000005122|UniProtKB=F7BXX8	Uncharacterized protein	ISS			PTHR10024:SF344	SYNAPTOTAGMIN-7
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05918	p38 MAPK pathway	P06027	CREB	BOVIN|Gene=CREB1|UniProtKB=P27925	Cyclic AMP-responsive element-binding protein 1	ISS	1354612	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00018	EGF receptor signaling pathway	P00552	Ras	CHICK|Ensembl=ENSGALG00000006885|UniProtKB=P08642	GTPase HRas	ISS	87226391	PubMed	PTHR24070:SF385	GTPASE HRAS
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MONDO|Ensembl=ENSMODG00000011628|UniProtKB=F6U132	Actin-related protein 2/3 complex subunit 3	ISS	12473693	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=4600|UniProtKB=O00222	Metabotropic glutamate receptor 8	IDA	9407094	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00029	Huntington disease	P00778	NMDA receptor	MOUSE|MGI=MGI=95823|UniProtKB=Q03391	Glutamate receptor ionotropic, NMDA 2D	IDA	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2D.html	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P02734	Chorismate biosynthesis	P02874	Shikimate kinase	CHLTR|EnsemblGenome=CT_367|UniProtKB=O84372	Shikimate kinase	ISS			PTHR21087:SF0	SHIKIMATE KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MONDO|Ensembl=ENSMODG00000013079|UniProtKB=F7FB74	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PHYPA|Gene=PHYPADRAFT_225906|UniProtKB=A9TVP1	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	ANOGA|EnsemblGenome=AGAP002440|UniProtKB=Q17031	Cdc42 homolog	ISS	12932731	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00057	Wnt signaling pathway	P01443	Phospholipase C	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00029	Huntington disease	P00807	Actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	ISS	3487386	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P04393	Ras Pathway	P04558	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00010	B cell activation	P00402	Jnk	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00015	Circadian clock system	G01501	cry	MOUSE|MGI=MGI=1270859|UniProtKB=Q9R194	Cryptochrome-2	IDA	14507900	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00025	Hedgehog signaling pathway	P00685	Smoothened	MOUSE|MGI=MGI=108075|UniProtKB=P56726	Smoothened homolog	IDA	10021362	PubMed	PTHR11309:SF35	SMOOTHENED HOMOLOG
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00046	Oxidative stress response	P01129	JNK1/2	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00010	B cell activation	P00370	NFkappaB	RAT|RGD=1307189|UniProtKB=Q5U2Z4	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	ISS	9133421	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	HUMAN|HGNC=19663|UniProtKB=Q9UBI6	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00034	Integrin signalling pathway	P00936	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ORYSJ|EnsemblGenome=OS10G0510000|UniProtKB=A3C6D7	Actin-2	IC	14684598	PubMed	PTHR11937:SF252	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IDA	2837282	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00035	Interferon-gamma signaling pathway	P00956	SOCS	MONDO|Ensembl=ENSMODG00000023104|UniProtKB=F7AZP2	Uncharacterized protein	ISS	22247722	PubMed	PTHR44282:SF3	SUPPRESSOR OF CYTOKINE SIGNALING 5
P04397	p53 pathway by glucose deprivation	P04640	p53	MACMU|Ensembl=ENSMMUG00000016466|UniProtKB=F7GBH1	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00034	Integrin signalling pathway	P00951	Jnk	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	IDA	10207617	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00779	TBP	YEAST|SGD=S000000950|UniProtKB=P13393	TATA-box-binding protein	IPI	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00018	EGF receptor signaling pathway	P00564	Rac	ORYSJ|EnsemblGenome=OS02G0834000|UniProtKB=Q6EP31	Rac-like GTP-binding protein 5	ISS			PTHR24072:SF194	RAC-LIKE GTP-BINDING PROTEIN ARAC4-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=69424|UniProtKB=Q99P84	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	10934033	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00054	Toll receptor signaling pathway	P01368	MKK2	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	ARATH|TAIR=AT5G61210|UniProtKB=Q9S7P9	SNAP25 homologous protein SNAP33	ISS			PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00048	PI3 kinase pathway	G01544	GADD45	PANTR|Ensembl=ENSPTRG00000000842|UniProtKB=H2R902	Growth arrest and DNA-damage-inducible, alpha	ISS	10097101	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	HUMAN|HGNC=1388|UniProtKB=O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	14507926	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00005	Angiogenesis	P00208	MEKK1	RAT|RGD=620966|UniProtKB=Q62925	Mitogen-activated protein kinase kinase kinase 1	ISS	12049732	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	RAT|RGD=2871|UniProtKB=G3V824	Insulin-like growth factor 2 receptor, isoform CRA_b	ISS	13642251	gi	PTHR15071:SF17	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000001114|UniProtKB=E1B7L9	Serine/threonine-protein kinase	ISS	12676944	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MONDO|Ensembl=ENSMODG00000024440|UniProtKB=F7DJJ2	Muscarinic acetylcholine receptor	ISS	12181435	PubMed	PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02916	dTMP kinase	AQUAE|EnsemblGenome=aq_969|UniProtKB=O67099	Thymidylate kinase	ISS			PTHR10344:SF1	THYMIDYLATE KINASE
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MOUSE|MGI=MGI=109563|UniProtKB=P70658	C-X-C chemokine receptor type 4	ISS	11943720	PubMed	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P05917	Opioid proopiomelanocortin pathway	P06011	AC	MOUSE|MGI=MGI=102891|UniProtKB=P51829	Adenylate cyclase type 7	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00024	Glycolysis	P00679	Aldolase	XENTR|Xenbase=XB-GENE-1005023|UniProtKB=Q6NVQ9	Fructose-bisphosphate aldolase	ISS	9804954	PubMed	PTHR11627:SF3	FRUCTOSE-BISPHOSPHATE ALDOLASE C
P00034	Integrin signalling pathway	P00924	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00010	B cell activation	P00386	Calcineurin	HUMAN|HGNC=9315|UniProtKB=P16298	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	IDA	12091710	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DROME|FlyBase=FBgn0000042|UniProtKB=P10987	Actin-5C	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05970	TH	RAT|RGD=3853|UniProtKB=P04177	Tyrosine 3-monooxygenase	ISS	191290	OMIM	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CAEBR|Gene=CBG02161|UniProtKB=A8WS32	Protein CBG02161	ISS	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P02743	Formyltetrahydroformate biosynthesis	P02956	Formyl tetrahydrofolate deformylase	AQUAE|EnsemblGenome=aq_1818|UniProtKB=O67681	Formyltetrahydrofolate deformylase	ISS			PTHR42706:SF1	FORMYLTETRAHYDROFOLATE DEFORMYLASE 1, MITOCHONDRIAL-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	HUMAN|HGNC=1736|UniProtKB=P60953	Cell division control protein 42 homolog	IDA	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05915	Opioid proenkephalin pathway	P05994	G-protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00045	Notch signaling pathway	G01541	E(spl)-C genes	HUMAN|HGNC=5192|UniProtKB=Q14469	Transcription factor HES-1	ISS	14973298	PubMed	PTHR10985:SF19	TRANSCRIPTION FACTOR HES-1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	TAS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	PANTR|Ensembl=ENSPTRG00000014922|UniProtKB=H2QML4	Uncharacterized protein	ISS	12039949	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	IC	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	RAT|RGD=3806|UniProtKB=P47861	Synaptotagmin-5	RCA			PTHR10024:SF282	SYNAPTOTAGMIN-5
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	10802295	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00020	FAS signaling pathway	P00615	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00118	E-cadherin	MOUSE|MGI=MGI=88354|UniProtKB=P09803	Cadherin-1	IDA	12834808	PubMed	PTHR24027:SF319	CADHERIN-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-041114-26|UniProtKB=F1RE11	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00564	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00038	JAK/STAT signaling pathway	P01027	STAT	MACMU|Ensembl=ENSMMUG00000010707|UniProtKB=F7G8G5	Signal transducer and activator of transcription	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00890	ELK	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	ISS	11279280	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00056	VEGF signaling pathway	P01419	Ets	ORNAN|Ensembl=ENSOANG00000012104|UniProtKB=F7FH70	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00021	FGF signaling pathway	P00643	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00047	PDGF signaling pathway	P01174	Rho	MONDO|Ensembl=ENSMODG00000019894|UniProtKB=F6W5V4	Uncharacterized protein	ISS	14724572	PubMed	PTHR23176:SF28	RHO GTPASE-ACTIVATING PROTEIN 1
P04395	Vasopressin synthesis	P04593	Glycopeptide	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IC	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02762	Pentose phosphate pathway	P03071	Ribulose 5-P Isomerase	YEAST|SGD=S000005621|UniProtKB=Q12189	Ribose-5-phosphate isomerase	RCA			PTHR11934:SF0	RIBOSE-5-PHOSPHATE ISOMERASE
P00029	Huntington disease	P00796	Kainate receptor	HUMAN|HGNC=4583|UniProtKB=Q16478	Glutamate receptor ionotropic, kainate 5	IDA	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00018	EGF receptor signaling pathway	P00565	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	BRAFL|Gene=BRAFLDRAFT_87235|UniProtKB=C3ZEV9	Putative uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF245	AT16150P-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P02738	De novo purine biosynthesis	P02904	Guanylate kinase	PSEAE|EnsemblGenome=PA5336|UniProtKB=Q9HTM2	Guanylate kinase	ISS			PTHR23117:SF13	GUANYLATE KINASE
P00010	B cell activation	P00383	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IDA	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00029	Huntington disease	P00786	ARF	DICDI|dictyBase=DDB_G0289173|UniProtKB=O00909	ADP-ribosylation factor 1	IPI	11752622	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00018	EGF receptor signaling pathway	P00561	STAT	HUMAN|HGNC=11365|UniProtKB=Q14765	Signal transducer and activator of transcription 4	IGI	12496413	PubMed	PTHR11801:SF19	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 4
P00004	Alzheimer disease-presenilin pathway	P00114	actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g210933|UniProtKB=A7SEA7	Predicted protein	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00045	Notch signaling pathway	P01105	TACE	MACMU|Ensembl=ENSMMUG00000017507|UniProtKB=F6V4A7	Uncharacterized protein	ISS			PTHR11905:SF4	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 10
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	RCA	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02743	Formyltetrahydroformate biosynthesis	P02952	Methylene tetrahydrofolate dehydrogenase	ARATH|TAIR=AT3G12290|UniProtKB=Q9LHH7	Bifunctional protein FolD 2	ISS			PTHR10025:SF33	METHENYL TETRAHYDROFOLATE CYCLOHYDROLASE / NADP-DEPENDENT METHYLENE H4F DEHYDROGENASE
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00036	Interleukin signaling pathway	P00967	c-fos	MACMU|Ensembl=ENSMMUG00000010574|UniProtKB=A5A6H2	C-fos	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00052	TGF-beta signaling pathway	P01279	Smurfs	XENTR|Xenbase=XB-GENE-479046|UniProtKB=F6QUG6	Uncharacterized protein	ISS	11252892	PubMed	PTHR11254:SF293	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P00030	Hypoxia response via HIF activation	P00814	P300	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00388	PLC gamma2	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	IGI	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	IDA	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00036	Interleukin signaling pathway	P00973	PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01078	VAChT	PANTR|Ensembl=ENSPTRG00000002490|UniProtKB=H2Q1W2	Uncharacterized protein	ISS	7938002	PubMed	PTHR23506:SF13	VESICULAR ACETYLCHOLINE TRANSPORTER
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	MOUSE|MGI=MGI=1351338|UniProtKB=P97772	Metabotropic glutamate receptor 1	IC	9407094	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00049	Parkinson disease	P01211	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	IDA	93028473	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000014828|UniProtKB=F1N1E0	Uncharacterized protein	ISS	8386525	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00057	Wnt signaling pathway	P01451	Galpha	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00049	Parkinson disease	P01208	Hsp70	TAKRU|Ensembl=ENSTRUG00000005265|UniProtKB=H2SJP2	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF239	HEAT SHOCK COGNATE 71 KDA PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=12786|UniProtKB=O00755	Protein Wnt-7a	TAS	12549854	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00021	FGF signaling pathway	P00623	FGF	HUMAN|HGNC=3683|UniProtKB=P12034	Fibroblast growth factor 5	ISS			PTHR11486:SF23	FIBROBLAST GROWTH FACTOR 5
P02736	Coenzyme A biosynthesis	P02885	Pantothenate kinase	HUMAN|HGNC=19365|UniProtKB=Q9H999	Pantothenate kinase 3	ISS			PTHR12280:SF21	PANTOTHENATE KINASE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00018	EGF receptor signaling pathway	P00552	Ras	SCHPO|PomBase=SPAC17H9.09c|UniProtKB=P08647	Ras-like protein 1	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	IC	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P02751	Lysine biosynthesis	P03013	Aspartate semialdehyde dehydrogenase	BACSU|EnsemblGenome=BSU16750|UniProtKB=Q04797	Aspartate-semialdehyde dehydrogenase	ISS			PTHR10174:SF2	ASPARTATE-SEMIALDEHYDE DEHYDROGENASE
P00049	Parkinson disease	P01234	GRK	DROME|FlyBase=FBgn0260798|UniProtKB=P32865	G protein-coupled receptor kinase 1	IDA	8288567	PubMed	PTHR24355:SF18	PROTEIN-SERINE/THREONINE KINASE
P00053	T cell activation	P01322	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IGI	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00057	Wnt signaling pathway	P01457	GBeta	CRYNJ|EnsemblGenome=CND03830|UniProtKB=Q5KI86	Uncharacterized protein	IDA	10594037	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	XENTR|Xenbase=XB-GENE-494358|UniProtKB=F7DD95	Uncharacterized protein	ISS	7755637	PubMed	PTHR11848:SF130	INHIBIN BETA C CHAIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00052	TGF-beta signaling pathway	P01279	Smurfs	BOVIN|Ensembl=ENSBTAG00000019853|UniProtKB=F1N3W8	Uncharacterized protein	ISS	11252892	PubMed	PTHR11254:SF300	E3 UBIQUITIN-PROTEIN LIGASE SMURF2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00037	Ionotropic glutamate receptor pathway	P01021	Vglut	HUMAN|HGNC=20151|UniProtKB=Q8NDX2	Vesicular glutamate transporter 3	ISS	12815758	PubMed	PTHR11662:SF207	VESICULAR GLUTAMATE TRANSPORTER 3
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00570	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P02744	Fructose galactose metabolism	P02964	Hexose 1-P uridyltransferase	MOUSE|MGI=MGI=95638|UniProtKB=Q03249	Galactose-1-phosphate uridylyltransferase	ISS	1610789	PubMed	PTHR11943:SF1	GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MOUSE|MGI=MGI=102806|UniProtKB=P27038	Activin receptor type-2A	TAS	11252892	PubMed	PTHR23255:SF64	ACTIVIN RECEPTOR TYPE-2A
P00021	FGF signaling pathway	P00644	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	ISS	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00702	CPB	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	RCA			PTHR13808:SF5	CREB-BINDING PROTEIN
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04393	Ras Pathway	P04553	PAK	BOVIN|Ensembl=ENSBTAG00000015670|UniProtKB=E1B7J7	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00005	Angiogenesis	P00235	c-Fos	MACMU|Ensembl=ENSMMUG00000010574|UniProtKB=A5A6H2	C-fos	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00046	Oxidative stress response	P01131	MKP5	MACMU|Ensembl=ENSMMUG00000011485|UniProtKB=F7D870	Dual specificity protein phosphatase	ISS			PTHR10159:SF388	DUAL SPECIFICITY PROTEIN PHOSPHATASE 9
P00019	Endothelin signaling pathway	P00572	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MACMU|Ensembl=ENSMMUG00000003486|UniProtKB=F7E7H3	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF34	REGULATOR OF G-PROTEIN SIGNALING 1
P00059	p53 pathway	P04622	Sin3	RAT|RGD=1311598|UniProtKB=A0A0G2K3H5	Protein Sin3a	ISS	10441327	PubMed	PTHR12346:SF2	PAIRED AMPHIPATHIC HELIX PROTEIN SIN3A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000018361|UniProtKB=P60020	5-hydroxytryptamine receptor 1B	ISS	12441358	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P00057	Wnt signaling pathway	P01444	Wnt	CHICK|Ensembl=ENSGALG00000005396|UniProtKB=Q2LMP1	Protein Wnt-3a	IDA	8717036	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P00037	Ionotropic glutamate receptor pathway	P01005	NR2D	MOUSE|MGI=MGI=95823|UniProtKB=Q03391	Glutamate receptor ionotropic, NMDA 2D	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2D.html	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P06959	CCKR signaling map	P07088	RYR1/2/3	HUMAN|HGNC=10485|UniProtKB=Q15413	Ryanodine receptor 3	RCA	11279177	PubMed	PTHR13715:SF16	RYANODINE RECEPTOR 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06794	MAP2K1/2	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	RCA	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	RAT|RGD=2342|UniProtKB=P08482	Muscarinic acetylcholine receptor M1	IDA	10069496	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P04393	Ras Pathway	P04553	PAK	RAT|RGD=3250|UniProtKB=P35465	Serine/threonine-protein kinase PAK 1	IDA	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P02743	Formyltetrahydroformate biosynthesis	P02952	Methylene tetrahydrofolate dehydrogenase	CAEBR|Gene=CBG16896|UniProtKB=A8XQ07	Protein CBR-DAO-3	ISS			PTHR10025:SF57	DAUER OR AGING ADULT OVEREXPRESSION
P00059	p53 pathway	P01485	p53	PANTR|Ensembl=ENSPTRG00000008703|UniProtKB=H2QC53	Cellular tumor antigen p53	ISS	11313951	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00002	Alpha adrenergic receptor signaling pathway	P00078	Alpha1A/1B/1C	MOUSE|MGI=MGI=104774|UniProtKB=P97717	Alpha-1B adrenergic receptor	IC	6323229	PubMed	PTHR24248:SF17	ALPHA-1B ADRENERGIC RECEPTOR
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00024	Glycolysis	P00680	Phosphoglyceromutase	MACMU|Ensembl=ENSMMUG00000004598|UniProtKB=F6Q944	Bisphosphoglycerate mutase	ISS	2542247	PubMed	PTHR11931:SF11	BISPHOSPHOGLYCERATE MUTASE
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	CAEEL|WormBase=WBGene00004769|UniProtKB=P52166	Presenilin sel-12	IDA	7566091	PubMed	PTHR10202:SF13	PRESENILIN-2
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IGI	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00036	Interleukin signaling pathway	P00972	MNK1/2	BOVIN|Gene=MKNK1|UniProtKB=Q58D94	MAP kinase-interacting serine/threonine-protein kinase 1	ISS	9155018	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00021	FGF signaling pathway	P00633	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P02755	Methylmalonyl pathway	P03033	Propionyl-CoA carboxylase	PANTR|Ensembl=ENSPTRG00000006001|UniProtKB=H2Q7R4	Propionyl CoA carboxylase, alpha polypeptide	ISS			PTHR18866:SF104	PROPIONYL-COA CARBOXYLASE ALPHA CHAIN, MITOCHONDRIAL
P00012	Cadherin signaling pathway	P00475	Frizzled	MACMU|Ensembl=ENSMMUG00000006912|UniProtKB=F7EZ48	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF86	FRIZZLED-10
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02747	Histidine biosynthesis	P02986	Phosphoribosyl ATP pyrophosphatase	SCHPO|PomBase=SPBC29A3.02c|UniProtKB=O59667	Histidine biosynthesis bifunctional protein his7	ISS			PTHR42945:SF1	HISTIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN HISIE, CHLOROPLASTIC
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000019443|UniProtKB=F6R0Q4	Syntaxin-11	ISS	11067767	PubMed	PTHR19957:SF30	SYNTAXIN-11
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	14526383	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P05731	GABA-B receptor II signaling	P05752	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P06214	GBB signaling pathway	P06305	MAD	DROME|FlyBase=FBgn0011648|UniProtKB=P42003	Protein mothers against dpp	IGI	9395284	PubMed	PTHR13703:SF40	PROTEIN MOTHERS AGAINST DPP
P05731	GABA-B receptor II signaling	P05753	Ca channel	RAT|RGD=628852|UniProtKB=Q02294	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	15079861	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	RAT|RGD=1593806|UniProtKB=G3V8Y0	Protein Gng13	ISS	10391901	PubMed	PTHR15936:SF2	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-13
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P02785	Valine biosynthesis	P03216	Acetolactate synthase	CAEEL|WormBase=WBGene00020831|UniProtKB=O61856	Acetolactate synthase-like protein	ISS			PTHR18968:SF155	ACETOLACTATE SYNTHASE-LIKE PROTEIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	RCA	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00049	Parkinson disease	P01231	gamma-Synuclein	MACMU|Ensembl=ENSMMUG00000011849|UniProtKB=F7H4X8	Gamma-synuclein	ISS			PTHR13820:SF10	GAMMA-SYNUCLEIN
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MONDO|Ensembl=ENSMODG00000012331|UniProtKB=F7E2P1	Phosphoinositide phospholipase C	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P00018	EGF receptor signaling pathway	P00560	Raf-1	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	ISS			PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P02751	Lysine biosynthesis	P03008	Dihydrodipicolinate synthase	MYCTU|EnsemblGenome=Rv2753c|UniProtKB=P9WP25	4-hydroxy-tetrahydrodipicolinate synthase	ISS			PTHR12128:SF15	4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00059	p53 pathway	P01485	p53	DANRE|ZFIN=ZDB-GENE-990415-270|UniProtKB=P79734	Cellular tumor antigen p53	TAS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P05915	Opioid proenkephalin pathway	P05995	proenkephalin	RAT|RGD=68946|UniProtKB=P04094	Proenkephalin-A	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00021	FGF signaling pathway	P00644	p38	CAEEL|WormBase=WBGene00004055|UniProtKB=Q17446	Mitogen-activated protein kinase pmk-1	IGI	10514528	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P04371	5-Hydroxytryptamine biosynthesis	P04400	Aromatic L-amino acid decarboxylase	CAEEL|WormBase=WBGene00000239|UniProtKB=O45137	Biogenic Amine Synthesis related	ISS	7567987	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00059	p53 pathway	G04702	p53	MOUSE|MGI=MGI=1336991|UniProtKB=Q9JJP2	Tumor protein p73	TAS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	RAT|RGD=69261|UniProtKB=O70512	Cytokine-inducible SH2-containing protein (Fragment)	ISS	12645661	PubMed	PTHR44649:SF1	CYTOKINE-INDUCIBLE SH2-CONTAINING PROTEIN
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	XENTR|Xenbase=XB-GENE-487069|UniProtKB=F6RN85	Uncharacterized protein	ISS	10617630	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P04393	Ras Pathway	P04572	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01471	alpha-catenin	DANRE|ZFIN=ZDB-GENE-991207-24|UniProtKB=Q9PVF8	Catenin (Cadherin-associated protein), alpha	IDA	9362521	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01368	MKK2	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	DANRE|ZFIN=ZDB-GENE-040426-2150|UniProtKB=Q6NUX8	Rho-related GTP-binding protein RhoA-A	ISS	12024019	PubMed	PTHR24072:SF260	RHO-RELATED GTP-BINDING PROTEIN RHOA-A-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_114976|UniProtKB=C3YP58	Putative uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	ISS	10571227	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00004	Alzheimer disease-presenilin pathway	P00118	E-cadherin	HUMAN|HGNC=1762|UniProtKB=P22223	Cadherin-3	IDA	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P00047	PDGF signaling pathway	P01174	Rho	PANTR|Ensembl=ENSPTRG00000021658|UniProtKB=H2QYA3	Rho GTPase activating protein 6	ISS			PTHR12635:SF6	RHO GTPASE-ACTIVATING PROTEIN 6
P02731	Biotin biosynthesis	P02859	Dethiobiotin synthase	BACTN|EnsemblGenome=BT_1446|UniProtKB=Q8A7S8	ATP-dependent dethiobiotin synthetase BioD	ISS			PTHR43210:SF2	DETHIOBIOTIN SYNTHETASE
P04393	Ras Pathway	P04567	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00021	FGF signaling pathway	P00639	Shc	PANTR|Ensembl=ENSPTRG00000021091|UniProtKB=H2QXF3	Uncharacterized protein	ISS	98175964	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P05730	Endogenous cannabinoid signaling	P05748	mGluR	RAT|RGD=2742|UniProtKB=P23385	Metabotropic glutamate receptor 1	ISS	8314195	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00038	JAK/STAT signaling pathway	P01027	STAT	PANTR|Ensembl=ENSPTRG00000009199|UniProtKB=H2QD19	Signal transducer and activator of transcription	ISS	10835485	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00018	EGF receptor signaling pathway	P00549	EGF	HUMAN|HGNC=3229|UniProtKB=P01133	Pro-epidermal growth factor	RCA			PTHR44717:SF1	PRO-EPIDERMAL GROWTH FACTOR
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	HUMAN|HGNC=19663|UniProtKB=Q9UBI6	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IDA	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00034	Integrin signalling pathway	P00944	Actin	PANTR|Ensembl=ENSPTRG00000009762|UniProtKB=H2QE24	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00029	Huntington disease	P00799	JNK-2	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00018	EGF receptor signaling pathway	P00539	14-3-3	DANRE|ZFIN=ZDB-GENE-061023-2|UniProtKB=E7F354	Uncharacterized protein	ISS	91108808	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00589	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	NAS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	DANRE|ZFIN=ZDB-GENE-010705-1|UniProtKB=Q90Z40	Guanine nucleotide-binding protein subunit gamma	IC	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	HUMAN|HGNC=11640|UniProtKB=Q9HCS4	Transcription factor 7-like 1	TAS	12356903	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P04393	Ras Pathway	P04542	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05726	2-arachidonoylglycerol biosynthesis	P05736	DGL	RAT|RGD=3017|UniProtKB=Q06000	Lipoprotein lipase	RCA			PTHR11610:SF3	LIPOPROTEIN LIPASE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000014751|UniProtKB=H2R8D8	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00021	FGF signaling pathway	P00633	Ras	CHICK|Ensembl=ENSGALG00000014033|UniProtKB=E1BTS2	Uncharacterized protein	ISS	99084794	PubMed	PTHR24070:SF186	GTPASE KRAS
P00048	PI3 kinase pathway	P01188	Gbetagamma	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	IC	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00057	Wnt signaling pathway	P01457	GBeta	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IDA	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IDA	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05913	Enkephalin release	P05972	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P06587	Nicotine pharmacodynamics pathway	P06596	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8235613	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01444	Wnt	CHICK|Ensembl=ENSGALG00000005401|UniProtKB=Q3L251	Protein Wnt	IDA	11266476	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P00005	Angiogenesis	P00240	FRS-2	RAT|RGD=1308201|UniProtKB=A0A0G2JZZ5	Protein Frs2	ISS	12571252	PubMed	PTHR21258:SF40	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	TAS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PUCGT|EnsemblGenome=PGTG_05488|UniProtKB=E3K4I1	Actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00203	Erk	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00036	Interleukin signaling pathway	P00980	IRS1/2	CANLF|Ensembl=ENSCAFG00000010397|UniProtKB=E2RDB5	Uncharacterized protein	ISS	5031805	gi	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00029	Huntington disease	P00786	ARF	SCHPO|PomBase=SPBC4F6.18c|UniProtKB=P36579	ADP-ribosylation factor 1	IPI	12932731	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	TAS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00034	Integrin signalling pathway	P00931	Integrin beta	MACMU|Ensembl=ENSMMUG00000003289|UniProtKB=F7FG54	Integrin beta	ISS	280842	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	XENTR|Xenbase=XB-GENE-482228|UniProtKB=F6RYL1	Uncharacterized protein	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04393	Ras Pathway	P04546	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00029	Huntington disease	P00807	Actin	CHICK|Gene=ACTG2|UniProtKB=P63270	Actin, gamma-enteric smooth muscle	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	TAS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	ISS	1482697	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00057	Wnt signaling pathway	P01455	Smad4	BOVIN|Ensembl=ENSBTAG00000021772|UniProtKB=F1MD43	Mothers against decapentaplegic homolog	ISS	12736218	PubMed	PTHR13703:SF36	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00056	VEGF signaling pathway	P01411	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P00054	Toll receptor signaling pathway	P01375	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	HUMAN|HGNC=15576|UniProtKB=Q8WXR4	Myosin-IIIb	ISS			PTHR13140:SF311	MYOSIN-IIIB
P00029	Huntington disease	P00811	Arp2/3 complex	MOUSE|MGI=MGI=1915021|UniProtKB=Q9CPW4	Actin-related protein 2/3 complex subunit 5	ISS	12473693	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04585	TRH	PANTR|Ensembl=ENSPTRG00000015383|UniProtKB=H2QNC9	Uncharacterized protein	ISS	2126343	PubMed	PTHR17530:SF2	PRO-THYROTROPIN-RELEASING HORMONE
P00006	Apoptosis signaling pathway	P00274	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01171	PLCgamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00053	T cell activation	P01311	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00589	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	NAS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01150	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05918	p38 MAPK pathway	P06021	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12960248	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-956713|UniProtKB=Q5XGD8	Guanine nucleotide binding protein, beta 3	ISS	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	RCA	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04393	Ras Pathway	P04557	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00018	EGF receptor signaling pathway	P00542	EGFR	MONDO|Ensembl=ENSMODG00000015755|UniProtKB=F6ZSZ9	Uncharacterized protein (Fragment)	ISS	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00019	Endothelin signaling pathway	P00575	furin	PANTR|Ensembl=ENSPTRG00000007461|UniProtKB=H2QA34	Furin (Paired basic amino acid cleaving enzyme)	ISS	10956649	PubMed	PTHR42884:SF1	FURIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000007576|UniProtKB=H2QA92	Uncharacterized protein	ISS	12441358	PubMed	PTHR24229:SF20	SOMATOSTATIN RECEPTOR TYPE 5
P05917	Opioid proopiomelanocortin pathway	P06010	proopiomelanocortin	PANTR|Ensembl=ENSPTRG00000011721|UniProtKB=H2R8Y3	Uncharacterized protein	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	PANTR|Ensembl=ENSPTRG00000010295|UniProtKB=H2QF07	Uncharacterized protein	ISS	123810	OMIM	PTHR22952:SF98	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 3
P00059	p53 pathway	P04616	PDK1/2	SCHPO|PomBase=SPBC1778.10c|UniProtKB=Q9Y7J6	Serine/threonine-protein kinase ppk21	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05918	p38 MAPK pathway	P06028	MLK2	PANTR|Ensembl=ENSPTRG00000010989|UniProtKB=H2QGC0	Mitogen-activated protein kinase kinase kinase 10	ISS	9639556	PubMed	PTHR43997:SF5	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 10
P00019	Endothelin signaling pathway	P00577	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	10799299	PubMed	PTHR10048:SF14	PI-3 KINASE
P00034	Integrin signalling pathway	P00932	FAK	CANLF|Ensembl=ENSCAFG00000008670|UniProtKB=E2QTG4	Uncharacterized protein	ISS	10753828	PubMed	PTHR24418:SF94	PROTEIN-TYROSINE KINASE 2-BETA
P00019	Endothelin signaling pathway	P00572	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00049	Parkinson disease	P01227	20S proteasome	MONDO|Ensembl=ENSMODG00000012807|UniProtKB=F7DYR4	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF11	PROTEASOME SUBUNIT ALPHA TYPE-6
P00047	PDGF signaling pathway	P01142	p90RSK	BOVIN|Ensembl=ENSBTAG00000014447|UniProtKB=A4IFF4	Ribosomal protein S6 kinase	ISS	15226426	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00052	TGF-beta signaling pathway	P01289	I-Smads	HUMAN|HGNC=6772|UniProtKB=O43541	Mothers against decapentaplegic homolog 6	IGI	9335505	PubMed	PTHR13703:SF28	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 6
P00057	Wnt signaling pathway	P01452	NFAT	MACMU|Ensembl=ENSMMUG00000003370|UniProtKB=F7E8G2	Uncharacterized protein	ISS	12787506	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00012	Cadherin signaling pathway	P00462	Casein kinase II	PANTR|Ensembl=ENSPTRG00000013147|UniProtKB=H2QJS7	Uncharacterized protein	ISS	10617630	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00021	FGF signaling pathway	P00633	Ras	MONDO|Gene=KRAS|UniProtKB=Q07983	GTPase KRas	ISS	9869449	PubMed	PTHR24070:SF186	GTPASE KRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00107	kinesin	BOVIN|Gene=KLC3|UniProtKB=Q2TBQ9	Kinesin light chain 3	ISS	11740561	PubMed	PTHR19959:SF125	KINESIN LIGHT CHAIN 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01070	K+ channel	MACMU|Ensembl=ENSMMUG00000015918|UniProtKB=F7ASA7	Uncharacterized protein	ISS	12165472	PubMed	PTHR11537:SF6	POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 2
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	MOUSE|MGI=MGI=88296|UniProtKB=O55017	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	11976940	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00059	p53 pathway	P04635	Sumo-1 ligase	TAKRU|Ensembl=ENSTRUG00000008913|UniProtKB=H2TCL6	Small ubiquitin-related modifier	ISS			PTHR10562:SF50	SMALL UBIQUITIN-RELATED MODIFIER 3
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	MACMU|Ensembl=ENSMMUG00000017022|UniProtKB=F7HQZ9	Uncharacterized protein	ISS	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00046	Oxidative stress response	P01138	MKK4	CANLF|Ensembl=ENSCAFG00000017851|UniProtKB=F1PBB6	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04393	Ras Pathway	P04567	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Ensembl=ENSBTAG00000013202|UniProtKB=Q1RML2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1	ISS	15611108	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	HUMAN|HGNC=5467|UniProtKB=P11717	Cation-independent mannose-6-phosphate receptor	TAS	11081635	PubMed	PTHR15071:SF17	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
P00035	Interferon-gamma signaling pathway	P00956	SOCS	RAT|RGD=69273|UniProtKB=O88582	Suppressor of cytokine signaling 2	ISS	15032587	PubMed	PTHR44396:SF2	SUPPRESSOR OF CYTOKINE SIGNALING 2
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	ASHGO|EnsemblGenome=AGOS_AGL093W|UniProtKB=Q9HF56	Cell division control protein 42	ISS	4757952	gi	PTHR24072:SF192	CDC42 HOMOLOG
P04393	Ras Pathway	P04546	GSK3	BOVIN|Ensembl=ENSBTAG00000020756|UniProtKB=A6QLB8	GSK3A protein	ISS	2164470	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P06664	Gonadotropin-releasing hormone receptor pathway	P06722	PITX	MOUSE|MGI=MGI=109340|UniProtKB=P97474	Pituitary homeobox 2	RCA			PTHR24329:SF254	PITUITARY HOMEOBOX 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	HUMAN|HGNC=10004|UniProtKB=O75916	Regulator of G-protein signaling 9	IDA	9459445	PubMed	PTHR10845:SF170	REGULATOR OF G-PROTEIN SIGNALING 9
P00049	Parkinson disease	P01207	PLD2	RAT|RGD=3350|UniProtKB=P70498	Phospholipase D2	IDA	12615079	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	BOVIN|Ensembl=ENSBTAG00000000231|UniProtKB=F1MCE7	Receptor protein serine/threonine kinase	ISS	10683140	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04572	JNK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00021	FGF signaling pathway	P00641	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04398	p53 pathway feedback loops 2	P04660	SIAH-1	MOUSE|MGI=MGI=108064|UniProtKB=P61092	E3 ubiquitin-protein ligase SIAH1A	ISS	11389839	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00053	T cell activation	P01324	rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	14564011	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	DROME|FlyBase=FBgn0022710|UniProtKB=M9PEP2	Adenylyl cyclase 35C, isoform C	IGI	97431620	PubMed	PTHR11920:SF319	ADENYLATE CYCLASE TYPE 9
P00005	Angiogenesis	P00254	GTPase	PANTR|Ensembl=ENSPTRG00000040414|UniProtKB=H2RH27	Ras homolog gene family, member B	ISS	11973360	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P02769	Purine metabolism	P03119	5'-Nucleotidase	MOUSE|MGI=MGI=99782|UniProtKB=Q61503	5'-nucleotidase	IDA	3219501	gi	PTHR11575:SF25	5'-NUCLEOTIDASE
P00052	TGF-beta signaling pathway	P01284	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IC	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CHLRE|EnsemblGenome=CHLREDRAFT_129868|UniProtKB=A8IXZ0	Beta tubulin 1	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	RAT|RGD=69219|UniProtKB=P11884	Aldehyde dehydrogenase, mitochondrial	IC			PTHR11699:SF233	ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL
P00021	FGF signaling pathway	P00647	SHP2	MACMU|Ensembl=ENSMMUG00000013253|UniProtKB=F6ZJD8	Tyrosine-protein phosphatase non-receptor type	ISS	95163101	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MOUSE|MGI=MGI=2444552|UniProtKB=Q8BFZ3	Beta-actin-like protein 2	IDA	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00047	PDGF signaling pathway	P01164	PDK1/2	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04393	Ras Pathway	P04563	Ets	BOVIN|Ensembl=ENSBTAG00000002341|UniProtKB=A5PJG9	ETS1 protein	ISS	9157999	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00047	PDGF signaling pathway	P01152	RasGAP	ANOGA|EnsemblGenome=AGAP002729|UniProtKB=Q7QCN5	AGAP002729-PA	ISS	21296043	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00057	Wnt signaling pathway	P01465	Ggamma	MACMU|Ensembl=ENSMMUG00000014807|UniProtKB=F6W548	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	BOVIN|Ensembl=ENSBTAG00000005800|UniProtKB=F1N3G8	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00750	Rhodopsin kinase	BOVIN|Ensembl=ENSBTAG00000019963|UniProtKB=P28327	Rhodopsin kinase	IDA	8288567	PubMed	PTHR24355:SF11	RHODOPSIN KINASE
P00048	PI3 kinase pathway	P01192	p110	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00005	Angiogenesis	P00203	Erk	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=3346|UniProtKB=P10688	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	12860966	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000002245|UniProtKB=H2RYC6	Uncharacterized protein (Fragment)	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00018	EGF receptor signaling pathway	P00550	Grb2	CAEEL|WormBase=WBGene00004774|UniProtKB=P29355	Sex muscle abnormal protein 5	IGI	8307166	PubMed	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P04378	Beta2 adrenergic receptor signaling pathway	P04440	Beta2	RAT|RGD=2060|UniProtKB=P10608	Beta-2 adrenergic receptor	ISS	12063255	PubMed	PTHR24248:SF21	BETA-2 ADRENERGIC RECEPTOR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	BOVIN|Ensembl=ENSBTAG00000020756|UniProtKB=A6QLB8	GSK3A protein	ISS	183955	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	CHICK|Ensembl=ENSGALG00000006841|UniProtKB=E1BSY6	Uncharacterized protein	ISS			PTHR23431:SF3	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5
P00019	Endothelin signaling pathway	P00566	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ORYSJ|EnsemblGenome=OS06G0699400|UniProtKB=Q5Z859	Mitogen-activated protein kinase 4	IDA			PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	ANOGA|EnsemblGenome=AGAP001478|UniProtKB=Q7PXM3	AGAP001478-PA	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00812	Caspase 3	HUMAN|HGNC=1504|UniProtKB=P42574	Caspase-3	IDA	9323209	PubMed	PTHR10454:SF198	CASPASE-3
P00025	Hedgehog signaling pathway	P00682	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IDA	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008422|UniProtKB=F6VUT7	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000024633|UniProtKB=F1MBU9	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	TAS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000014751|UniProtKB=H2R8D8	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00056	VEGF signaling pathway	P01413	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00045	Notch signaling pathway	P01104	Serrate	MONDO|Ensembl=ENSMODG00000004910|UniProtKB=F7C1Q4	Delta-like protein	ISS	1286675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01305	Calmodulin	ORYSJ|EnsemblGenome=OS01G0267900|UniProtKB=Q0JNS6	Calmodulin-1	ISS	10487978	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00057	Wnt signaling pathway	P01451	Galpha	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00056	VEGF signaling pathway	P01407	Erk	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=4597|UniProtKB=P41594	Metabotropic glutamate receptor 5	IDA			PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P02787	Vitamin B6 metabolism	P03229	Pyridoxal reductase	ARATH|TAIR=AT5G53580|UniProtKB=Q56Y42	Pyridoxal reductase, chloroplastic	RCA			PTHR43625:SF5	PYRIDOXAL REDUCTASE, CHLOROPLASTIC
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00029	Huntington disease	P00800	PolyQ Htt	HUMAN|HGNC=4851|UniProtKB=P42858	Huntingtin	TAS	8268927	PubMed	PTHR10170:SF10	HUNTINGTIN
P00021	FGF signaling pathway	P00648	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00029	Huntington disease	P00777	CBP	MOUSE|MGI=MGI=1276116|UniProtKB=B2RWS6	Histone acetyltransferase p300	ISS	10769018	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00053	T cell activation	P01323	I kappa B	PANTR|Ensembl=ENSPTRG00000006265|UniProtKB=H2Q867	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	ISS	10811867	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02738	De novo purine biosynthesis	P02909	GDP reductase	STRCO|Gene=CAB94610|UniProtKB=Q9K3C2	Ribonucleoside-diphosphate reductase subunit beta	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00022	General transcription by RNA polymerase I	P00656	PTRF	HUMAN|HGNC=9688|UniProtKB=Q6NZI2	Polymerase I and transcript release factor	ISS	603198	OMIM	PTHR15240:SF3	POLYMERASE I AND TRANSCRIPT RELEASE FACTOR
P00034	Integrin signalling pathway	P00907	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01323	I kappa B	RAT|RGD=3171|UniProtKB=Q63746	NF-kappa-B inhibitor alpha	ISS	14665694	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00049	Parkinson disease	P01236	Casein kinase II	ORYSJ|EnsemblGenome=OS03G0207300|UniProtKB=Q10Q71	Casein kinase II, alpha chain, putative, expressed	IDA	10617630	PubMed	PTHR24054:SF35	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00010	B cell activation	P00401	jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00006	Apoptosis signaling pathway	P00327	FADD	HUMAN|HGNC=3573|UniProtKB=Q13158	FAS-associated death domain protein	IDA	9506948	PubMed	PTHR15077:SF8	FAS-ASSOCIATED DEATH DOMAIN PROTEIN
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00590	IP3 R	ANOGA|EnsemblGenome=AGAP006475|UniProtKB=Q5TQX0	AGAP006475-PA	ISS	12880387	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	IDA	10207617	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00047	PDGF signaling pathway	P01151	PKB	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00383	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	DROME|FlyBase=FBgn0263111|UniProtKB=P91645	Voltage-dependent calcium channel type A subunit alpha-1	ISS	14624853	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00036	Interleukin signaling pathway	P00962	ELK	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	IDA	11151091	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00047	PDGF signaling pathway	P01154	Ras	CHICK|Ensembl=ENSGALG00000014033|UniProtKB=E1BTS2	Uncharacterized protein	ISS	3023884	PubMed	PTHR24070:SF186	GTPASE KRAS
P00057	Wnt signaling pathway	P01450	Bcl9	CANLF|Ensembl=ENSCAFG00000011046|UniProtKB=E2QWH2	Uncharacterized protein	ISS	11955446	PubMed	PTHR15185:SF5	B-CELL CLL/LYMPHOMA 9 PROTEIN
P04398	p53 pathway feedback loops 2	P04665	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02769	Purine metabolism	P03119	5'-Nucleotidase	HUMAN|HGNC=8021|UniProtKB=P21589	5'-nucleotidase	NAS	3219501	gi	PTHR11575:SF25	5'-NUCLEOTIDASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P06959	CCKR signaling map	P07054	PKCepsilon	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	RCA	9230117	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01211	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04398	p53 pathway feedback loops 2	P04663	Mdm2	PANTR|Ensembl=ENSPTRG00000005203|UniProtKB=H2R792	Mdm2 p53 binding protein homolog	ISS	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01076	CAT	CANLF|Ensembl=ENSCAFG00000006672|UniProtKB=F1PR75	Uncharacterized protein	ISS	92155737	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	PANTR|Ensembl=ENSPTRG00000005438|UniProtKB=H2RBJ1	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P06587	Nicotine pharmacodynamics pathway	P06614	TH	PANTR|Ensembl=ENSPTRG00000003173|UniProtKB=H2Q2W7	Uncharacterized protein	ISS	191290	OMIM	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00047	PDGF signaling pathway	P01169	Vav	CANLF|Ensembl=ENSCAFG00000018590|UniProtKB=E2RGT8	Uncharacterized protein	ISS	14623913	PubMed	PTHR22826:SF112	PROTO-ONCOGENE VAV
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000014976|UniProtKB=H2R892	Uncharacterized protein	ISS	20012997	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014555|UniProtKB=F7GT55	Syntaxin-1A isoform 1	ISS	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00021	FGF signaling pathway	P00624	14-3-3	MOUSE|MGI=MGI=891963|UniProtKB=P68254	14-3-3 protein theta	IDA	10407019	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04555	PDK	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00212	EphR	BOVIN|Ensembl=ENSBTAG00000005313|UniProtKB=F1ML02	Uncharacterized protein	ISS	9990854	PubMed	PTHR24416:SF120	EPHRIN TYPE-B RECEPTOR 3
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000012293|UniProtKB=F7DRD8	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF290	CADHERIN-10
P00047	PDGF signaling pathway	P01169	Vav	MONDO|Ensembl=ENSMODG00000002796|UniProtKB=F7EJL2	Uncharacterized protein	ISS	14623913	PubMed	PTHR22826:SF97	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00017	DNA replication	P00527	Histones	PUCGT|EnsemblGenome=PGTG_06100|UniProtKB=E3K5M6	Histone H3	ISS	12413958	PubMed	PTHR11426:SF47	SUBFAMILY NOT NAMED
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00029	Huntington disease	P00780	Microtubule	XENTR|Xenbase=XB-GENE-6259095|UniProtKB=Q5BL39	Tubulin, beta 2	ISS	9454836	PubMed	PTHR11588:SF93	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00235	c-Fos	MACMU|Ensembl=ENSMMUG00000010574|UniProtKB=A5A6H2	C-fos	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	20384797	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00572	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00054	Toll receptor signaling pathway	P01375	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	RAT|RGD=3694|UniProtKB=Q01827	Synaptic vesicular amine transporter	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000025240|UniProtKB=F7A7I3	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CANLF|Ensembl=ENSCAFG00000018564|UniProtKB=E2RHU1	Uncharacterized protein	ISS	20112749	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00048	PI3 kinase pathway	P01181	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04393	Ras Pathway	P04547	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	CANLF|Ensembl=ENSCAFG00000004930|UniProtKB=E2RFB5	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00038	JAK/STAT signaling pathway	P01031	PIAS	HUMAN|HGNC=16861|UniProtKB=Q9Y6X2	E3 SUMO-protein ligase PIAS3	ISS	8682149	PubMed	PTHR10782:SF10	E3 SUMO-PROTEIN LIGASE PIAS3
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00115	Nicastrin	PANTR|Ensembl=ENSPTRG00000001550|UniProtKB=H2Q0E4	Nicastrin	ISS	10993067	PubMed	PTHR21092:SF0	NICASTRIN
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	ORNAN|Ensembl=ENSOANG00000010302|UniProtKB=F6TDQ6	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00048	PI3 kinase pathway	P01177	P110ACT	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01168	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P01485	p53	RAT|RGD=3889|UniProtKB=P10361	Cellular tumor antigen p53	TAS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00030	Hypoxia response via HIF activation	P00819	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	HUMAN|HGNC=20093|UniProtKB=Q8N142	Adenylosuccinate synthetase isozyme 1	IEP	10636885	PubMed	PTHR11846:SF2	ADENYLOSUCCINATE SYNTHETASE ISOZYME 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00639	Shc	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	ISS	7680960	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	CANLF|Ensembl=ENSCAFG00000030049|UniProtKB=J9NWQ5	Uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF311	CALMODULIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	PANTR|Ensembl=ENSPTRG00000010386|UniProtKB=H2QF61	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	DANRE|Ensembl=ENSDARG00000070511|UniProtKB=E7F5R2	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF282	GLUTAMATE RECEPTOR-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00021	FGF signaling pathway	P00631	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8617307	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	CHICK|Ensembl=ENSGALG00000017238|UniProtKB=F1NWG3	Uncharacterized protein	ISS	14614461	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2521|UniProtKB=P19020	D(3) dopamine receptor	IDA	11248120	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MONDO|Ensembl=ENSMODG00000016960|UniProtKB=F6V5G0	Uncharacterized protein	ISS	20012997	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P04397	p53 pathway by glucose deprivation	P04636	S6K	RAT|RGD=620683|UniProtKB=P67999	Ribosomal protein S6 kinase beta-1	IDA	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00034	Integrin signalling pathway	P00907	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05913	Enkephalin release	P05972	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	10553940	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	HUMAN|HGNC=4594|UniProtKB=Q14416	Metabotropic glutamate receptor 2	IDA			PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95814|UniProtKB=Q60934	Glutamate receptor ionotropic, kainate 1	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-969601|UniProtKB=Q28H40	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	IDA	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00053	T cell activation	P01332	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00017	DNA replication	P00536	DNA Topisomerase	DROME|FlyBase=FBgn0004924|UniProtKB=P30189	DNA topoisomerase 1	ISS			PTHR10290:SF3	DNA TOPOISOMERASE 1
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	1171954	gi	PTHR10048:SF14	PI-3 KINASE
P00047	PDGF signaling pathway	P01159	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	RAT|RGD=2736|UniProtKB=P35439	Glutamate receptor ionotropic, NMDA 1	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00046	Oxidative stress response	P01129	JNK1/2	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	ARATH|TAIR=AT3G02160|UniProtKB=Q9S7R9	At3g02160	ISS	604903	OMIM	PTHR12321:SF53	BROMODOMAIN TRANSCRIPTION FACTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	MACMU|Ensembl=ENSMMUG00000013140|UniProtKB=F6Z9H7	Uncharacterized protein	ISS			PTHR24361:SF345	SERINE/THREONINE-PROTEIN KINASE PAK 4
P00006	Apoptosis signaling pathway	P00317	Fos	MACMU|Ensembl=ENSMMUG00000010574|UniProtKB=A5A6H2	C-fos	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00059	p53 pathway	P04623	CBP	BOVIN|Ensembl=ENSBTAG00000016198|UniProtKB=E1B8D6	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00057	Wnt signaling pathway	P01451	Galpha	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02750	Lipoate_biosynthesis	P03004	Lipoate synthase	ANOGA|EnsemblGenome=AGAP010568|UniProtKB=Q7Q8T4	AGAP010568-PA (Fragment)	ISS			PTHR10949:SF0	LIPOYL SYNTHASE, MITOCHONDRIAL
P00023	General transcription regulation	P00667	TFIIFbeta	RAT|RGD=620772|UniProtKB=Q01750	General transcription factor IIF subunit 2	ISS			PTHR10445:SF0	GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00048	PI3 kinase pathway	P01196	PDK1	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00006	Apoptosis signaling pathway	P00269	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	11251832	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ARATH|TAIR=AT3G18780|UniProtKB=Q96292	Actin-2	ISS	11889126	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04395	Vasopressin synthesis	P04597	Signal Peptide	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00049	Parkinson disease	P01211	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00401	jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	8837781	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DICDI|dictyBase=DDB_G0279413|UniProtKB=P05987	cAMP-dependent protein kinase regulatory subunit	IC	91298951	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00057	Wnt signaling pathway	P01435	SWI/SNF	PANTR|Ensembl=ENSPTRG00000019882|UniProtKB=H2QVN0	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3	ISS	11532957	PubMed	PTHR13844:SF5	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D MEMBER 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CRYNJ|EnsemblGenome=CNA04650|UniProtKB=Q5KP06	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000033526|UniProtKB=E1B8Q3	Guanine nucleotide binding protein 13, gamma-like	ISS	10391901	PubMed	PTHR15936:SF2	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-13
P00011	Blood coagulation	P00435	FVa	MOUSE|MGI=MGI=88382|UniProtKB=O88783	Coagulation factor V	ISS	6679731	gi	PTHR45199:SF1	COAGULATION FACTOR V
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	BOVIN|Gene=IGF2R|UniProtKB=P08169	Cation-independent mannose-6-phosphate receptor	ISS	13642251	gi	PTHR15071:SF17	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01150	PKC	MACMU|Ensembl=ENSMMUG00000020588|UniProtKB=F7C0E0	Uncharacterized protein	ISS	11554554	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P05918	p38 MAPK pathway	P06031	p38alpha	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	RCA	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P06664	Gonadotropin-releasing hormone receptor pathway	P06768	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	RCA	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	MACMU|Ensembl=ENSMMUG00000023790|UniProtKB=F7HT93	Protein-serine/threonine kinase	ISS	10852916	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00019	Endothelin signaling pathway	P00573	signal peptidase	CAEBR|Gene=CBG04194|UniProtKB=A8WWE1	Signal peptidase complex catalytic subunit SEC11	ISS	2674115	PubMed	PTHR10806:SF6	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00018	EGF receptor signaling pathway	P00551	Akt	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	IGI	14526383	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00057	Wnt signaling pathway	P01448	CBP	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	IDA	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	ARATH|TAIR=AT1G54560|UniProtKB=F4HWY6	Myosin-11	IC			PTHR13140:SF706	UNCONVENTIONAL MYOSIN-VI
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00021	FGF signaling pathway	P00642	MEK1-2	CAEBR|Gene=CBG04190|UniProtKB=A8WWD7	Protein CBR-MEK-2	ISS	12024031	PubMed	PTHR24361:SF629	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1
P04397	p53 pathway by glucose deprivation	P04641	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01038	Vglut	RAT|RGD=620101|UniProtKB=Q62634	Vesicular glutamate transporter 1	ISS	15192755	PubMed	PTHR11662:SF138	VESICULAR GLUTAMATE TRANSPORTER 1
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IGI	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00047	PDGF signaling pathway	P01168	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	14526383	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	91056091	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P04392	P53 pathway feedback loops 1	P04536	Mdm2	CANLF|Ensembl=ENSCAFG00000009669|UniProtKB=E2RDT3	Uncharacterized protein	ISS			PTHR13844:SF20	PROTEIN MDM4
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00017	DNA replication	P00535	5' to 3' Exoribonulcease	HUMAN|HGNC=12836|UniProtKB=Q9H0D6	5'-3' exoribonuclease 2	ISS	99339991	PubMed	PTHR12341:SF41	5'-3' EXORIBONUCLEASE 2
P00006	Apoptosis signaling pathway	P00307	ELF2alpha	SCHMA|EnsemblGenome=Smp_093750|UniProtKB=Q95W35	Eukaryotic translation initiation factor 2 alpha subunit	ISS			PTHR10602:SF0	EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1
P00048	PI3 kinase pathway	P01202	p85	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00012	Cadherin signaling pathway	P00470	F-actin	PANTR|Ensembl=ENSPTRG00000009762|UniProtKB=H2QE24	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	HUMAN|HGNC=10435|UniProtKB=Q9UK32	Ribosomal protein S6 kinase alpha-6	ISS	6755374	gi	PTHR24351:SF98	RIBOSOMAL PROTEIN S6 KINASE ALPHA-6
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00006	Apoptosis signaling pathway	P00318	PKCs	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05917	Opioid proopiomelanocortin pathway	P06007	alpha-MSH	DANRE|ZFIN=ZDB-GENE-041014-294|UniProtKB=Q5SPP4	Uncharacterized protein	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00053	T cell activation	P01311	Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	IDA	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	HALSA|EnsemblGenome=VNG_1830G|UniProtKB=Q9HP32	CTP synthase	ISS			PTHR11550:SF0	CTP SYNTHASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CANLF|Gene=DRD2|UniProtKB=Q9GJU1	D(2) dopamine receptor	IDA	11861492	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	TAS	10644715	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00010	B cell activation	P00371	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04393	Ras Pathway	P04547	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IDA	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00006	Apoptosis signaling pathway	P00271	Bax	MOUSE|MGI=MGI=99702|UniProtKB=Q07813	Apoptosis regulator BAX	IDA	11099028	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	CHICK|Ensembl=ENSGALG00000012894|UniProtKB=P30372	Muscarinic acetylcholine receptor M2	ISS	91373358	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	STRPU|Gene=CYIIIA|UniProtKB=P53474	Actin, cytoskeletal 3A	ISS	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00015	Circadian clock system	P00505	Cry	CANLF|Ensembl=ENSCAFG00000009379|UniProtKB=F1PNC9	Uncharacterized protein	ISS	11804325	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	RAT|RGD=1309427|UniProtKB=Q3KRE8	Tubulin beta-2B chain	ISS	9454836	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000022175|UniProtKB=F6XHY0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	97449291	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00006	Apoptosis signaling pathway	P00310	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P06959	CCKR signaling map	G06986	CCND1	HUMAN|HGNC=1582|UniProtKB=P24385	G1/S-specific cyclin-D1	RCA	18515095	PubMed	PTHR10177:SF67	G1/S-SPECIFIC CYCLIN-D1
P05916	Opioid prodynorphin pathway	P06002	G-protein	BOVIN|Ensembl=ENSBTAG00000003043|UniProtKB=P63212	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00507	Rho	SCHPO|PomBase=SPAC16A10.04|UniProtKB=Q874R1	GTP-binding protein rho4	ISS			PTHR24072:SF181	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05916	Opioid prodynorphin pathway	P05999	provasopressin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00005	Angiogenesis	P00205	GAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	8270251	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00927	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05731	GABA-B receptor II signaling	P05758	K channel	PANTR|Ensembl=ENSPTRG00000012547|UniProtKB=H2QIU3	Uncharacterized protein	ISS	12374786	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00057	Wnt signaling pathway	P01451	Galpha	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014555|UniProtKB=F7GT55	Syntaxin-1A isoform 1	ISS	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00006	Apoptosis signaling pathway	P00260	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CHICK|Ensembl=ENSGALG00000011809|UniProtKB=F1NMB0	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00020	FAS signaling pathway	P00616	Nuclear Lamin	DANRE|ZFIN=ZDB-GENE-020424-3|UniProtKB=B3DKC5	Lamin A	TAS	11165516	PubMed	PTHR23239:SF158	PRELAMIN-A/C
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8706|UniProtKB=Q9Y5G5	Protocadherin gamma-A8	IDA	8120095	PubMed	PTHR24028:SF72	PROTOCADHERIN GAMMA-A8
P00011	Blood coagulation	P00429	PN2	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	ISS	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00211	GSK3beta	DICDI|dictyBase=DDB_G0272110|UniProtKB=P51136	Glycogen synthase kinase-3	ISS			PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	IC	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00018	EGF receptor signaling pathway	P00543	ERK1-2	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	IGI	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	YEAST|SGD=S000005762|UniProtKB=P07807	Dihydrofolate reductase	ISS			PTHR11548:SF3	DIHYDROFOLATE REDUCTASE
P00056	VEGF signaling pathway	P01413	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00054	Toll receptor signaling pathway	P01346	TLR	MACMU|Ensembl=ENSMMUG00000009112|UniProtKB=F7HU26	Toll-like receptor 4	ISS			PTHR44568:SF1	TOLL-LIKE RECEPTOR 4
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00019	Endothelin signaling pathway	P00566	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	BOVIN|Ensembl=ENSBTAG00000005464|UniProtKB=E1B9K3	Uncharacterized protein	ISS	92357702	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P05918	p38 MAPK pathway	P05919	MAPKAP-K3	HUMAN|HGNC=6888|UniProtKB=Q16644	MAP kinase-activated protein kinase 3	ISS	11157753	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P05731	GABA-B receptor II signaling	P05754	Ggamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00047	PDGF signaling pathway	P01174	Rho	MOUSE|MGI=MGI=1920417|UniProtKB=Q9CXP4	Rho GTPase-activating protein 8	ISS			PTHR23176:SF3	PROTEIN PRR5-ARHGAP8-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04380	Cortocotropin releasing factor receptor signaling pathway	P04452	proopiomelanocortin	DANRE|ZFIN=ZDB-GENE-030513-2|UniProtKB=Q7ZT18	Pro-opiomelanocortin protein	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00029	Huntington disease	P00776	c-Jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P02738	De novo purine biosynthesis	P02899	GMP synthase	METAC|EnsemblGenome=MA_4511|UniProtKB=Q8THK3	GMP synthase [glutamine-hydrolyzing] subunit B	ISS			PTHR11922:SF2	GMP SYNTHASE  GLUTAMINE-HYDROLYZING
P00046	Oxidative stress response	P01129	JNK1/2	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00807	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g188243|UniProtKB=A7SCN8	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00754	PDEgamma	TAKRU|Ensembl=ENSTRUG00000005502|UniProtKB=H2SLD9	Uncharacterized protein	ISS			PTHR12122:SF4	RETINAL ROD RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT GAMMA
P00010	B cell activation	P00376	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	6264430	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04545	Sec5	HUMAN|HGNC=24968|UniProtKB=Q96KP1	Exocyst complex component 2	ISS			PTHR13043:SF1	EXOCYST COMPLEX COMPONENT 2
P00029	Huntington disease	P00780	Microtubule	ARATH|TAIR=AT1G75780|UniProtKB=P12411	Tubulin beta-1 chain	IDA	12932731	PubMed	PTHR11588:SF116	TUBULIN BETA-1 CHAIN-RELATED
P00025	Hedgehog signaling pathway	P00691	CBP	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00049	Parkinson disease	P01208	Hsp70	ENTHI|EnsemblGenome=EHI_199590|UniProtKB=C4M770	70 kDa heat shock protein, putative	IDA	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00010	B cell activation	P00384	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00034	Integrin signalling pathway	P00924	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01199	Galpha	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IC	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	TAKRU|Ensembl=ENSTRUG00000011169|UniProtKB=H2TU36	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00919	Arf6	BOVIN|Ensembl=ENSBTAG00000045980|UniProtKB=G3N3N1	Uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	BOVIN|Ensembl=ENSBTAG00000008026|UniProtKB=P01175	Oxytocin-neurophysin 1	ISS	1706187	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	ARATH|TAIR=AT3G08510|UniProtKB=Q39033	Phosphoinositide phospholipase C 2	ISS			PTHR10336:SF92	PHOSPHOINOSITIDE PHOSPHOLIPASE C 2-RELATED
P00018	EGF receptor signaling pathway	P00558	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00048	PI3 kinase pathway	P01177	P110ACT	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IGI	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00046	Oxidative stress response	P01135	p38	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	8925912	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P02783	Tryptophan biosynthesis	P03208	Tryptophan synthase B	MYCTU|EnsemblGenome=Rv1612|UniProtKB=P9WFX9	Tryptophan synthase beta chain	ISS			PTHR42882:SF1	TRYPTOPHAN SYNTHASE
P00053	T cell activation	P01300	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01312	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00021	FGF signaling pathway	P00645	Rac	ARATH|TAIR=AT4G28950|UniProtKB=O82480	Rac-like GTP-binding protein ARAC7	ISS	12932731	PubMed	PTHR24072:SF127	RAC-LIKE GTP-BINDING PROTEIN ARAC7
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	BOVIN|Gene=VTI1B|UniProtKB=Q2KIU0	Vesicle transport through interaction with t-SNAREs homolog 1B	ISS	14570579	PubMed	PTHR21230:SF26	VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1B
P00012	Cadherin signaling pathway	P00470	F-actin	PHYPA|Gene=PHYPADRAFT_109052|UniProtKB=A9TZ58	Actin 5	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00049	Parkinson disease	P01230	Src kinase	MACMU|Ensembl=ENSMMUG00000020131|UniProtKB=F7FWN4	Tyrosine-protein kinase	ISS	8054685	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00012	Cadherin signaling pathway	P00474	Wnt	MONDO|Ensembl=ENSMODG00000015364|UniProtKB=F6WHM2	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P00018	EGF receptor signaling pathway	P00557	PI3K	CANAL|CGD=CAL0068551|UniProtKB=Q5AAR9	Phosphatidylinositol 3-kinase	IGI	20330542	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00021	FGF signaling pathway	P00644	p38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00007	Axon guidance mediated by semaphorins	P00340	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P05730	Endogenous cannabinoid signaling	P05751	Galpha	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	RAT|RGD=621705|UniProtKB=Q8VHN2	Glutamate receptor ionotropic, NMDA 3B	ISS	14698601	PubMed	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P00020	FAS signaling pathway	P00620	CytochromeC	HUMAN|HGNC=2579|UniProtKB=P08574	Cytochrome c1, heme protein, mitochondrial	ISS	15163634	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P05731	GABA-B receptor II signaling	P05754	Ggamma	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P02781	Threonine biosynthesis	P03189	Aspartate kinase	BACSU|EnsemblGenome=BSU03790|UniProtKB=P94417	Aspartokinase 3	ISS			PTHR21499:SF38	ASPARTOKINASE 1, CHLOROPLASTIC
P00046	Oxidative stress response	P01138	MKK4	PANTR|Ensembl=ENSPTRG00000008783|UniProtKB=H2QCA7	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00047	PDGF signaling pathway	P01161	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04546	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	RAT|RGD=69346|UniProtKB=G3V7U3	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00018	EGF receptor signaling pathway	P00541	Spry	PANTR|Ensembl=ENSPTRG00000005951|UniProtKB=H2Q7P2	Sprouty homolog 2	ISS	12225946	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00633	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IGI	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	IC	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00048	PI3 kinase pathway	P01202	p85	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	IDA	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	G04694	p110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05918	p38 MAPK pathway	P06029	p38beta	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00049	Parkinson disease	P01238	14-3-3	MONDO|Ensembl=ENSMODG00000009856|UniProtKB=F6WA79	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00006	Apoptosis signaling pathway	P00317	Fos	MACMU|Ensembl=ENSMMUG00000010574|UniProtKB=A5A6H2	C-fos	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02731	Biotin biosynthesis	P02856	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	YEAST|SGD=S000005341|UniProtKB=P50277	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	ISS			PTHR42684:SF3	ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	RCA	2372396	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00045	Notch signaling pathway	P01101	Su(H)	RAT|RGD=1310557|UniProtKB=F1LNW1	Protein Rbpj	ISS	12145413	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	HUMAN|HGNC=667|UniProtKB=P61586	Transforming protein RhoA	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00048	PI3 kinase pathway	P01205	NOS	HUMAN|HGNC=7876|UniProtKB=P29474	Nitric oxide synthase, endothelial	ISS	9837777	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00010	B cell activation	P00371	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00775	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	8649368	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P02787	Vitamin B6 metabolism	P03236	Pyridoxamine phosphate oxidase	STRCO|EnsemblGenome=CAB95898|UniProtKB=Q9K3V7	Pyridoxine/pyridoxamine 5'-phosphate oxidase	ISS	12000953	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00029	Huntington disease	P00805	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	STRPU|EnsemblGenome=SPU_006797|UniProtKB=W4XTP5	Uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P06587	Nicotine pharmacodynamics pathway	P06604	SLC18A2	RAT|RGD=3694|UniProtKB=Q01827	Synaptic vesicular amine transporter	TAS	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P05731	GABA-B receptor II signaling	P05760	AC	RAT|RGD=2035|UniProtKB=Q03343	Adenylate cyclase type 6	RCA	2491850	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BOVIN|Gene=ACTB|UniProtKB=P60712	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TRIAD|EnsemblGenome=TriadG63375|UniProtKB=B3S5E4	Non-muscle actin 6.2	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05913	Enkephalin release	P05974	G-Protein (i)	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	ISS	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00061	PNMT	HUMAN|HGNC=7861|UniProtKB=P40261	Nicotinamide N-methyltransferase	ISS			PTHR10867:SF5	NICOTINAMIDE N-METHYLTRANSFERASE
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04393	Ras Pathway	P04567	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IDA	129387	gi	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	9860142	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	AQUAE|EnsemblGenome=aq_903|UniProtKB=O67050	tRNA-specific adenosine deaminase	ISS			PTHR11079:SF149	TRNA-SPECIFIC ADENOSINE DEAMINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	HUMAN|HGNC=9509|UniProtKB=P49810	Presenilin-2	IDA	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	STRCO|Gene=CAB66175|UniProtKB=Q9RDS6	Probable glutamine synthetase (EC 6.3.1.2)	ISS			PTHR43785:SF1	TYPE-1 GLUTAMINE SYNTHETASE 2
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00034	Integrin signalling pathway	P00907	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01219	SAPK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00810	GAPDH	SCLS1|Gene=SS1G_07798|UniProtKB=A7ER45	Glyceraldehyde-3-phosphate dehydrogenase	IPI			PTHR10836:SF52	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00047	PDGF signaling pathway	P01162	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00034	Integrin signalling pathway	P00916	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000022175|UniProtKB=F6XHY0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	IC	176892	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P05918	p38 MAPK pathway	P06021	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00059	p53 pathway	P04624	Cdc25C	XENTR|Xenbase=XB-GENE-944821|UniProtKB=F7B6Y3	Uncharacterized protein (Fragment)	ISS	1623517	PubMed	PTHR10828:SF64	M-PHASE INDUCER PHOSPHATASE 3
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	PANTR|Ensembl=ENSPTRG00000000543|UniProtKB=H2PYN8	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01286	TGFbeta	XENTR|Xenbase=XB-GENE-481419|UniProtKB=F6UHX6	Uncharacterized protein (Fragment)	ISS	9759503	PubMed	PTHR11848:SF151	EMBRYONIC GROWTH/DIFFERENTIATION FACTOR 1
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P06217	Toll pathway-drosophila	P06349	SPZ	DROME|FlyBase=FBgn0003495|UniProtKB=P48607	Protein spaetzle	IDA	8124709	PubMed	PTHR23199:SF12	NEUROTROPHIN 1, ISOFORM F-RELATED
P00021	FGF signaling pathway	P00629	PP2A	DROME|FlyBase=FBgn0004889|UniProtKB=P36872	Protein phosphatase PP2A 55 kDa regulatory subunit	ISS			PTHR11871:SF0	PROTEIN PHOSPHATASE PP2A 55 KDA REGULATORY SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05730	Endogenous cannabinoid signaling	P05746	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00012	Cadherin signaling pathway	P00475	Frizzled	BOVIN|Ensembl=ENSBTAG00000002283|UniProtKB=F1N4K7	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF31	FRIZZLED-7
P04396	Vitamin D metabolism and pathway	P04607	FDX	ARATH|TAIR=AT4G21090|UniProtKB=Q8S904	Adrenodoxin-like protein 2, mitochondrial	ISS			PTHR23426:SF25	FERREDOXIN 2
P06664	Gonadotropin-releasing hormone receptor pathway	P06782	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	RCA	176910	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00056	VEGF signaling pathway	P01411	Ras	DICDI|dictyBase=DDB_G0293434|UniProtKB=P15064	Ras-like protein rasG	ISS	7997267	PubMed	PTHR24070:SF282	RAS GTPASE-RELATED
P00030	Hypoxia response via HIF activation	P00819	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00463	betacatenin	MOUSE|MGI=MGI=88276|UniProtKB=Q02248	Catenin beta-1	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P00018	EGF receptor signaling pathway	P00544	c-Cbl	MACMU|Ensembl=ENSMMUG00000003271|UniProtKB=F7FKP6	Uncharacterized protein	ISS	99289203	PubMed	PTHR23007:SF12	E3 UBIQUITIN-PROTEIN LIGASE CBL-C
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04393	Ras Pathway	P04543	MEKK1/4	BOVIN|Ensembl=ENSBTAG00000020079|UniProtKB=F1N3T0	Uncharacterized protein	ISS	602425	OMIM	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	TAKRU|Ensembl=ENSTRUG00000015213|UniProtKB=H2UPJ1	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF356	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	MONDO|Ensembl=ENSMODG00000028212|UniProtKB=F7BYN4	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00019	Endothelin signaling pathway	P00589	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IGI	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01170	PDGF	MACMU|Ensembl=ENSMMUG00000002739|UniProtKB=F7HKP4	Uncharacterized protein	ISS			PTHR11633:SF2	PLATELET-DERIVED GROWTH FACTOR SUBUNIT B
P00046	Oxidative stress response	P01128	MEF-2	CANLF|Ensembl=ENSCAFG00000010775|UniProtKB=F6XZU9	Uncharacterized protein	ISS	11274345	PubMed	PTHR11945:SF256	MYOCYTE-SPECIFIC ENHANCER FACTOR 2A
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000000712|UniProtKB=F6YS32	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF322	CADHERIN-6
P00021	FGF signaling pathway	P00638	PLCgamma	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00029	Huntington disease	P00796	Kainate receptor	CHICK|Ensembl=ENSGALG00000015434|UniProtKB=F1NU20	Uncharacterized protein	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	MONDO|Ensembl=ENSMODG00000028212|UniProtKB=F7BYN4	Signal transducer and activator of transcription	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00024	Glycolysis	P00680	Phosphoglyceromutase	CANLF|Ensembl=ENSCAFG00000003165|UniProtKB=E2QYX1	Uncharacterized protein	ISS	2542247	PubMed	PTHR11931:SF11	BISPHOSPHOGLYCERATE MUTASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CHICK|Ensembl=ENSGALG00000009844|UniProtKB=P68034	Actin, alpha cardiac muscle 1	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05913	Enkephalin release	P05977	G-Protein (s)	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01438	PP2A	CANLF|Ensembl=ENSCAFG00000006453|UniProtKB=F6X958	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	BRAFL|Gene=BRAFLDRAFT_124869|UniProtKB=C3ZEW0	Putative uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF263	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IDA	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00005	Angiogenesis	P00200	Dsh	RAT|RGD=620632|UniProtKB=Q9WVB9	Segment polarity protein dishevelled homolog DVL-1	ISS	7906389	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P00049	Parkinson disease	P01219	SAPK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	NAS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	HUMAN|HGNC=8930|UniProtKB=Q16816	Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	IDA	1370475	PubMed	PTHR44087:SF1	PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, SKELETAL MUSCLE/HEART ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IGI	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P02738	De novo purine biosynthesis	P02899	GMP synthase	SULSO|EnsemblGenome=SSO2451|UniProtKB=Q97VZ9	GMP synthase [glutamine-hydrolyzing] subunit A	ISS			PTHR11922:SF2	GMP SYNTHASE  GLUTAMINE-HYDROLYZING
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	MONDO|Ensembl=ENSMODG00000005927|UniProtKB=F6WX28	Uncharacterized protein	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04393	Ras Pathway	P04566	Stat 1/3	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	14755057	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P05918	p38 MAPK pathway	P06013	ELK	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	11151091	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00036	Interleukin signaling pathway	P00983	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000013587|UniProtKB=F7AZ16	Phosphoinositide phospholipase C	ISS			PTHR10336:SF33	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-3
P00006	Apoptosis signaling pathway	P00269	MAPK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02738	De novo purine biosynthesis	P02902	ADP reductase	PANTR|Ensembl=ENSPTRG00000020481|UniProtKB=H2QWI9	Ribonucleotide reductase M2 B (TP53 inducible)	ISS			PTHR23409:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 B
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01448	CBP	ARATH|TAIR=AT1G79000|UniProtKB=Q9C5X9	Histone acetyltransferase HAC1	ISS	10769018	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	8387895	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00053	T cell activation	P01311	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MONDO|Ensembl=ENSMODG00000017550|UniProtKB=F7E0Z1	Uncharacterized protein	ISS	14570579	PubMed	PTHR19957:SF90	SYNTAXIN-7
P00019	Endothelin signaling pathway	P00590	IP3 R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IGI	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CHICK|Ensembl=ENSGALG00000027629|UniProtKB=Q5ZJ03	Guanine nucleotide-binding protein subunit gamma	IDA	9754712	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00053	T cell activation	P01329	CD45	HUMAN|HGNC=9666|UniProtKB=P08575	Receptor-type tyrosine-protein phosphatase C	IGI	8940015	PubMed	PTHR19134:SF284	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C
P02776	Serine glycine biosynthesis	P03160	Phosphoglycerate dehydrogenase	YEAST|SGD=S000001336|UniProtKB=P40510	D-3-phosphoglycerate dehydrogenase 2	ISS			PTHR10996:SF165	D-3-PHOSPHOGLYCERATE DEHYDROGENASE 1-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MONDO|Ensembl=ENSMODG00000011628|UniProtKB=F6U132	Actin-related protein 2/3 complex subunit 3	ISS	9359840	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	TAS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	PANTR|Ensembl=ENSPTRG00000028511|UniProtKB=H2R570	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF81	FRIZZLED-1
P04393	Ras Pathway	P04570	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00973	PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00007	Axon guidance mediated by semaphorins	P00334	PlexinA1	BOVIN|Ensembl=ENSBTAG00000009159|UniProtKB=E1BFR4	Uncharacterized protein	ISS	10725340	PubMed	PTHR22625:SF35	PLEXIN-A1
P05731	GABA-B receptor II signaling	P05752	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	ISS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TRIAD|EnsemblGenome=TriadG56111|UniProtKB=B3RX77	Non-muscle actin 6.2	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00019	Endothelin signaling pathway	P00591	PLCbeta	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	DEIRA|EnsemblGenome=DR_1718|UniProtKB=Q9RTN9	Glutamate dehydrogenase	ISS			PTHR43571:SF1	NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BOVIN|Gene=ACTG2|UniProtKB=Q5E9B5	Actin, gamma-enteric smooth muscle	ISS	3487386	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00036	Interleukin signaling pathway	P00977	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	HUMAN|HGNC=7850|UniProtKB=P22392	Nucleoside diphosphate kinase B	ISS			PTHR11349:SF57	NUCLEOSIDE DIPHOSPHATE KINASE B
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00221	JNK1	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IGI	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	BOVIN|Ensembl=ENSBTAG00000009245|UniProtKB=Q0P594	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00029	Huntington disease	P00775	Rac	DICPU|Gene=DICPUDRAFT_92985|UniProtKB=F1A084	Putative uncharacterized protein rac1A	ISS			PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MACMU|Ensembl=ENSMMUG00000021725|UniProtKB=F7E738	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IGI	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00005	Angiogenesis	P00255	Notch	TAKRU|Ensembl=ENSTRUG00000017773|UniProtKB=H2V8M1	Uncharacterized protein (Fragment)	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00005	Angiogenesis	P00243	Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00053	T cell activation	P01322	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	MOUSE|MGI=MGI=109482|UniProtKB=P97445	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	IDA	15699344	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00052	TGF-beta signaling pathway	P01284	JNK	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=99217|UniProtKB=P55288	Cadherin-11	IDA	8120095	PubMed	PTHR24027:SF85	CADHERIN-11
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00056	VEGF signaling pathway	P01425	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IGI	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DROME|FlyBase=FBgn0003093|UniProtKB=P13678	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00021	FGF signaling pathway	P00624	14-3-3	ENTHI|EnsemblGenome=EHI_006810|UniProtKB=C4M0F4	14-3-3 protein 3	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	IC	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P02734	Chorismate biosynthesis	P02870	3-Phosphoshikimate-1-carboxyvinyl transferase	CHLTR|EnsemblGenome=CT_366|UniProtKB=O84371	3-phosphoshikimate 1-carboxyvinyltransferase	ISS			PTHR21090:SF5	PENTAFUNCTIONAL AROM POLYPEPTIDE
P00005	Angiogenesis	P00254	GTPase	BOVIN|Ensembl=ENSBTAG00000014299|UniProtKB=Q1RMJ6	Rho-related GTP-binding protein RhoC	ISS	12090470	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DICDI|dictyBase=DDB_G0279413|UniProtKB=P05987	cAMP-dependent protein kinase regulatory subunit	IC	91072385	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00058	mRNA splicing	P01473	U6	MONDO|Ensembl=ENSMODG00000018774|UniProtKB=F7ADZ9	Uncharacterized protein	ISS	12875835	PubMed	PTHR14212:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	15572354	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	RAT|RGD=1309332|UniProtKB=D3ZZ42	Matrix metalloproteinase 21 (Predicted)	ISS	12834808	PubMed	PTHR10201:SF147	MATRIX METALLOPROTEINASE-21
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CHLRE|EnsemblGenome=CHLREDRAFT_193901|UniProtKB=Q9FXT7	Mitogen-activated protein kinase	ISS			PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00048	PI3 kinase pathway	P01193	IRS	PANTR|Ensembl=ENSPTRG00000012989|UniProtKB=H2QJJ4	Insulin receptor substrate 1	ISS	12701063	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00048	PI3 kinase pathway	P01188	Gbetagamma	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	ORNAN|Ensembl=ENSOANG00000010680|UniProtKB=F6U4A0	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00034	Integrin signalling pathway	P00912	Arp2/3	MACMU|Ensembl=ENSMMUG00000022808|UniProtKB=F6UWC3	Actin-related protein 2/3 complex subunit 2	ISS	10940259	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00036	Interleukin signaling pathway	P00996	STAT	HUMAN|HGNC=11363|UniProtKB=P52630	Signal transducer and activator of transcription 2	IC			PTHR11801:SF41	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 2
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00057	Wnt signaling pathway	P01429	Axin	MOUSE|MGI=MGI=1270862|UniProtKB=O88566	Axin-2	IDA	12356903	PubMed	PTHR10845:SF103	AXIN-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00010	B cell activation	P00398	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IGI	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010034|UniProtKB=F1PEE8	Uncharacterized protein	ISS	8930069	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P02734	Chorismate biosynthesis	P02871	2-Deoxy-7-phosphoheptulonate synthase	GLOVI|Gene=BAC88675|UniProtKB=Q7NMN1	Phospho-2-dehydro-3-deoxyheptonate aldolase	ISS			PTHR21225:SF12	PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, PHE-SENSITIVE
P00010	B cell activation	P00384	p38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IDA	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P06959	CCKR signaling map	P07090	MAPK8-10	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	RCA	9003778	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00005	Angiogenesis	P00237	FRP	MOUSE|MGI=MGI=1196625|UniProtKB=O70421	Frizzled-1	ISS	8717036	PubMed	PTHR11309:SF81	FRIZZLED-1
P02734	Chorismate biosynthesis	P02872	3-Dehydroquinate synthase	BACTN|EnsemblGenome=BT_3975|UniProtKB=Q8A0P6	3-dehydroquinate synthase	ISS			PTHR43622:SF2	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01444	Wnt	CHICK|Gene=WNT8C|UniProtKB=P51030	Protein Wnt-8c	IDA	11266476	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	DAPPU|EnsemblGenome=DAPPUDRAFT_206575|UniProtKB=E9FUX0	Guanine nucleotide binding protein, beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00007	Axon guidance mediated by semaphorins	P00338	Neuropilin 1	DANRE|ZFIN=ZDB-GENE-030519-2|UniProtKB=Q8QFX6	Neuropilin-1a	ISS			PTHR44185:SF1	NEUROPILIN-1
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MOUSE|MGI=MGI=1933206|UniProtKB=A2AIR5	Protein Grin3a	ISS	11554554	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008018|UniProtKB=F7EPG4	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00006	Apoptosis signaling pathway	P00321	HSP70	CANAL|CGD=CAL0000184706|UniProtKB=P41797	Heat shock protein SSA1	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	G04671	proopiomelanocortin	PANTR|Ensembl=ENSPTRG00000011721|UniProtKB=H2R8Y3	Uncharacterized protein	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=107469|UniProtKB=Q8K3R3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	15611108	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01063	CAT	ANOGA|EnsemblGenome=AGAP002370|UniProtKB=Q7QBZ0	AGAP002370-PA (Fragment)	IC	92155737	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P02738	De novo purine biosynthesis	P02900	AICAR transformylase	YEAST|SGD=S000004727|UniProtKB=P38009	Bifunctional purine biosynthesis protein ADE17	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CHICK|Ensembl=ENSGALG00000008898|UniProtKB=F1P2J9	Uncharacterized protein	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	TAKRU|Ensembl=ENSTRUG00000011517|UniProtKB=H2TWL9	Uncharacterized protein (Fragment)	ISS	12941441	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	CAEEL|WormBase=WBGene00017610|UniProtKB=Q19599	Uncharacterized protein	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=2683547|UniProtKB=Q4KWH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1	ISS	12860966	PubMed	PTHR10336:SF51	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04397	p53 pathway by glucose deprivation	P04640	p53	BOVIN|Ensembl=ENSBTAG00000001069|UniProtKB=P67939	Cellular tumor antigen p53	TAS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00019	Endothelin signaling pathway	P00578	eNOS	RAT|RGD=3186|UniProtKB=Q62600	Nitric oxide synthase, endothelial	ISS	22462730	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P05918	p38 MAPK pathway	P06020	p38delta	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	RCA	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05730	Endogenous cannabinoid signaling	P05751	Galpha	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	RCA	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00047	PDGF signaling pathway	P01171	PLCgamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	ORNAN|Ensembl=ENSOANG00000011166|UniProtKB=F7D5G3	Phosphoinositide phospholipase C	ISS			PTHR10336:SF84	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2
P00049	Parkinson disease	P01230	Src kinase	HUMAN|HGNC=2444|UniProtKB=P41240	Tyrosine-protein kinase CSK	IDA	12665526	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	SYNY3|EnsemblGenome=BAA18679|UniProtKB=P74572	Pyrroline-5-carboxylate reductase	ISS			PTHR11645:SF0	PYRROLINE-5-CARBOXYLATE REDUCTASE
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	MYCTU|EnsemblGenome=LH57_13380|UniProtKB=I6Y0R5	Dihydrofolate synthase	ISS			PTHR11136:SF0	DIHYDROFOLATE SYNTHETASE-RELATED
P00057	Wnt signaling pathway	P01457	GBeta	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00023	General transcription regulation	P00658	TBP-associated factors	ARATH|TAIR=AT4G34340|UniProtKB=Q9SYZ9	Transcription initiation factor TFIID subunit 8	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00049	Parkinson disease	P01227	20S proteasome	HUMAN|HGNC=9530|UniProtKB=P25786	Proteasome subunit alpha type-1	ISS	12859888	PubMed	PTHR11599:SF12	PROTEASOME SUBUNIT ALPHA TYPE-RELATED
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01428	Frizzled	MONDO|Ensembl=ENSMODG00000010505|UniProtKB=F7E9U1	Uncharacterized protein (Fragment)	ISS	11212302	PubMed	PTHR11309:SF81	FRIZZLED-1
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	PSEAE|EnsemblGenome=PA5119|UniProtKB=Q9HU65	Glutamine synthetase	ISS			PTHR43407:SF1	LENGSIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00018	EGF receptor signaling pathway	P00546	GAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	20908895	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	CHICK|Gene=GOT2|UniProtKB=P00508	Aspartate aminotransferase, mitochondrial	ISS			PTHR11879:SF32	ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	TAS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00020	FAS signaling pathway	P00615	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00034	Integrin signalling pathway	P00923	Arf1	MONDO|Ensembl=ENSMODG00000024451|UniProtKB=F6Z8M9	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF234	ADP-RIBOSYLATION FACTOR 1
P00048	PI3 kinase pathway	P01177	P110ACT	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00046	Oxidative stress response	P01129	JNK1/2	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00019	Endothelin signaling pathway	P00586	Gq	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00059	p53 pathway	G04689	Cyclin G	BOVIN|Ensembl=ENSBTAG00000006607|UniProtKB=Q5E9I1	Cyclin-G1	ISS	12556559	PubMed	PTHR10177:SF59	CYCLIN-G1
P04393	Ras Pathway	P04557	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00056	VEGF signaling pathway	P01407	Erk	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	HUMAN|HGNC=15906|UniProtKB=A7E2Y1	Myosin-7B	IEP	89264452	PubMed	PTHR13140:SF358	MYOSIN-7B
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	MACMU|Ensembl=ENSMMUG00000003857|UniProtKB=F7HA84	Nucleoside diphosphate kinase	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CAEEL|WormBase=WBGene00004055|UniProtKB=Q17446	Mitogen-activated protein kinase pmk-1	IDA	10851062	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00010	B cell activation	P00388	PLC gamma2	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DROME|FlyBase=FBgn0000042|UniProtKB=P10987	Actin-5C	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02765	Phenylalanine biosynthesis	P03100	Chorismate mutase	ARATH|TAIR=AT1G69370|UniProtKB=Q9C544	Chorismate mutase 3, chloroplastic	ISS			PTHR21145:SF3	CHORISMATE MUTASE 3, CHLOROPLASTIC
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	CHICK|Ensembl=ENSGALG00000011473|UniProtKB=F1P1H2	Ribosomal protein S6 kinase	ISS	1922062	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	IC	http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=101848|UniProtKB=P62881	Guanine nucleotide-binding protein subunit beta-5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P06959	CCKR signaling map	G07262	HDC	HUMAN|HGNC=4855|UniProtKB=P19113	Histidine decarboxylase	RCA	9341140	PubMed	PTHR11999:SF68	HISTIDINE DECARBOXYLASE
P00011	Blood coagulation	P00458	GP IIIa	MOUSE|MGI=MGI=96612|UniProtKB=O54890	Integrin beta-3	ISS	20069419	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00021	FGF signaling pathway	P00640	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04392	P53 pathway feedback loops 1	P04537	p73DeltaN	CHICK|Ensembl=ENSGALG00000007324|UniProtKB=F1N8Z7	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00018	EGF receptor signaling pathway	P00562	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008026|UniProtKB=H2QAZ2	Syntaxin 1B	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00019	Endothelin signaling pathway	P00590	IP3 R	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	IGI	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05915	Opioid proenkephalin pathway	P05994	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	RAT|RGD=2850|UniProtKB=Q62758	5-hydroxytryptamine receptor 4	IDA	15118808	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02783	Tryptophan biosynthesis	P03206	Anthranilate synthase	BACSU|EnsemblGenome=BSU22680|UniProtKB=P03963	Anthranilate synthase component 1	ISS			PTHR11236:SF9	ANTHRANILATE SYNTHASE COMPONENT 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00010	B cell activation	P00391	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00206	Wnt	MOUSE|MGI=MGI=98953|UniProtKB=P04426	Proto-oncogene Wnt-1	ISS	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00059	p53 pathway	P04633	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CANLF|Ensembl=ENSCAFG00000009672|UniProtKB=E2RDT2	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00005	Angiogenesis	P00217	STAT3	MONDO|Ensembl=ENSMODG00000028212|UniProtKB=F7BYN4	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P02747	Histidine biosynthesis	P02993	Phosphoribosylformimino-5-amino-1-phosphoribosyl-4 imadazol carboxamide isomerase	NEUCR|EnsemblGenome=EFNCRG00000000077|UniProtKB=Q7RXQ8	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase	ISS			PTHR43090:SF2	1- 5-PHOSPHORIBOSYL -5-  5-PHOSPHORIBOSYLAMINO METHYLIDENEAMINO  IMIDAZOLE-4-CARBOXAMIDE ISOMERASE
P00049	Parkinson disease	P01237	Complex I	YARLI|EnsemblGenome=YALI0_D00737g|UniProtKB=F2Z6C0	YALI0D00737p	TAS	3100899	PubMed	PTHR10371:SF3	NADH DEHYDROGENASE  UBIQUINONE  FLAVOPROTEIN 2, MITOCHONDRIAL
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	9395335	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02738	De novo purine biosynthesis	P02909	GDP reductase	YEAST|SGD=S000003412|UniProtKB=P49723	Ribonucleoside-diphosphate reductase small chain 2	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00019	Endothelin signaling pathway	P00589	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00182	p38MAPK	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	RCA	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00060	Ubiquitin proteasome pathway	P01491	E2	MOUSE|MGI=MGI=1913355|UniProtKB=P61079	Ubiquitin-conjugating enzyme E2 D3	ISS			PTHR24068:SF48	UBIQUITIN-CONJUGATING ENZYME E2 D3
P00048	PI3 kinase pathway	P01202	p85	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00005	Angiogenesis	P00217	STAT3	MONDO|Ensembl=ENSMODG00000028212|UniProtKB=F7BYN4	Signal transducer and activator of transcription	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000001056|UniProtKB=H2PZL0	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P00021	FGF signaling pathway	P00632	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01006	NR2C	HUMAN|HGNC=4587|UniProtKB=Q14957	Glutamate receptor ionotropic, NMDA 2C	ISS	11554549	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00001	Adrenaline and noradrenaline biosynthesis	P00071	VAT1	MACMU|Ensembl=ENSMMUG00000019999|UniProtKB=F7FNE2	Uncharacterized protein	ISS	11443533	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00010	B cell activation	P00371	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00049	Parkinson disease	P01211	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	CANLF|Ensembl=ENSCAFG00000010815|UniProtKB=F1PKH2	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF141	TRANSFORMING GROWTH FACTOR BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00199	JNKK1	BOVIN|Ensembl=ENSBTAG00000012103|UniProtKB=A5PJP8	MAP2K4 protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PHYPA|Gene=PHYPADRAFT_225906|UniProtKB=A9TVP1	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	TAS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05915	Opioid proenkephalin pathway	P05993	AC	RAT|RGD=619965|UniProtKB=P26769	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04393	Ras Pathway	P04542	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	18021322	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	MACMU|Ensembl=ENSMMUG00000020037|UniProtKB=F7GDJ3	Anti-Muellerian hormone type-2 receptor	ISS	9395284	PubMed	PTHR23255:SF49	ANTI-MUELLERIAN HORMONE TYPE-2 RECEPTOR
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04396	Vitamin D metabolism and pathway	P04608	24-Hydroxylase	RAT|RGD=2462|UniProtKB=Q09128	1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	IDA	11686044	PubMed	PTHR24291:SF5	1,25-DIHYDROXYVITAMIN D 3  24-HYDROXYLASE, MITOCHONDRIAL
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00623	FGF	MOUSE|MGI=MGI=95521|UniProtKB=P36363	Fibroblast growth factor 7	ISS	8634153	PubMed	PTHR11486:SF20	FIBROBLAST GROWTH FACTOR 7
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00931	Integrin beta	RAT|RGD=2929|UniProtKB=G3V7M2	Integrin beta	ISS	12391210	PubMed	PTHR10082:SF36	INTEGRIN BETA-7
P00009	Axon guidance mediated by netrin	P00363	PI3K	XENTR|Xenbase=XB-GENE-6067221|UniProtKB=F6Z0J4	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	YEAST|SGD=S000001667|UniProtKB=P08432	Ornithine decarboxylase	ISS			PTHR11482:SF6	ORNITHINE DECARBOXYLASE 1-RELATED
P00045	Notch signaling pathway	P01120	NIcs	MACMU|Ensembl=ENSMMUG00000018375|UniProtKB=F7H1D5	Neurogenic locus notch homolog protein 2 isoform 1 preproprotein	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00059	p53 pathway	P01485	p53	PANTR|Ensembl=ENSPTRG00000015733|UniProtKB=H2QNY5	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00013	Cell cycle	P00480	Proteasome	PANTR|Ensembl=ENSPTRG00000013893|UniProtKB=H2PZY5	Uncharacterized protein	ISS	10505793	PubMed	PTHR10223:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	MOUSE|MGI=MGI=97512|UniProtKB=P21661	Neuroendocrine convertase 2	IDA			PTHR42884:SF13	NEUROENDOCRINE CONVERTASE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00038	JAK/STAT signaling pathway	P01034	Jak	CANLF|Ensembl=ENSCAFG00000018615|UniProtKB=F1PIY7	Tyrosine-protein kinase	ISS	9637709	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IGI	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CAEBR|Gene=CBG02401|UniProtKB=A8WUE7	Protein CBR-NMR-1	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	DANRE|ZFIN=ZDB-GENE-020125-4|UniProtKB=F1QKT1	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	MOUSE|MGI=MGI=97513|UniProtKB=P23188	Furin	IDA	95328031	PubMed	PTHR42884:SF1	FURIN
P00057	Wnt signaling pathway	P01455	Smad4	MACMU|Ensembl=ENSMMUG00000018384|UniProtKB=F7GZL6	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P00005	Angiogenesis	P00211	GSK3beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00005	Angiogenesis	P00189	Fzd	MOUSE|MGI=MGI=108476|UniProtKB=Q61086	Frizzled-3	ISS	11212302	PubMed	PTHR11309:SF22	FRIZZLED-3
P00046	Oxidative stress response	P01135	p38	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00013	Cell cycle	P00480	Proteasome	RAT|RGD=1305236|UniProtKB=B0BN93	26S proteasome non-ATPase regulatory subunit 13	ISS	99239941	PubMed	PTHR10539:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13
P00006	Apoptosis signaling pathway	P00260	AKT	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	ISS	12089061	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P02785	Valine biosynthesis	P03217	Dihydroxy isovalerate reductoisomerase	AQUAE|EnsemblGenome=aq_1245|UniProtKB=O67289	Ketol-acid reductoisomerase	ISS			PTHR21371:SF1	KETOL-ACID REDUCTOISOMERASE, CHLOROPLASTIC
P05913	Enkephalin release	P05977	G-Protein (s)	MOUSE|MGI=MGI=102705|UniProtKB=P63213	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00029	Huntington disease	P00790	beta-Tubulin	CHICK|Ensembl=ENSGALG00000026802|UniProtKB=G1K338	Uncharacterized protein	TAS	9454836	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P04393	Ras Pathway	P04542	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05918	p38 MAPK pathway	P06034	MKK4	CHICK|Ensembl=ENSGALG00000001001|UniProtKB=F1P3T1	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00034	Integrin signalling pathway	P00922	Collagen	RAT|RGD=70922|UniProtKB=Q9JI04	Alpha 4 type V collagen	IDA	10778855	PubMed	PTHR24023:SF567	COLLAGEN ALPHA-3 V  CHAIN
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000024633|UniProtKB=F1MBU9	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00057	Wnt signaling pathway	P01435	SWI/SNF	ORYSJ|EnsemblGenome=OS01G0367900|UniProtKB=Q7G8Y3	Probable chromatin-remodeling complex ATPase chain	ISS	11532957	PubMed	PTHR10799:SF879	CHROMATIN-REMODELING COMPLEX ATPASE CHAIN ISWI
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02918	dUTP pyrophosphatase	MACMU|Ensembl=ENSMMUG00000016898|UniProtKB=F7CQ88	Uncharacterized protein	ISS			PTHR11241:SF6	DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE, MITOCHONDRIAL
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=105057|UniProtKB=P55284	Cadherin-5	IDA	8120095	PubMed	PTHR24027:SF89	CADHERIN-5
P00011	Blood coagulation	P00426	PC	PANTR|Ensembl=ENSPTRG00000012428|UniProtKB=H2QIN8	Uncharacterized protein	ISS	4506115	gi	PTHR24278:SF0	VITAMIN K-DEPENDENT PROTEIN C
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MOUSE|MGI=MGI=1859709|UniProtKB=P97492	Regulator of G-protein signaling 14	IDA	8756726	PubMed	PTHR10845:SF179	REGULATOR OF G-PROTEIN SIGNALING 14
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MOUSE|MGI=MGI=2155600|UniProtKB=Q91Z83	Myosin-7	ISS	89264452	PubMed	PTHR13140:SF344	MYOSIN-7
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P06959	CCKR signaling map	P07218	FAK2	HUMAN|HGNC=9612|UniProtKB=Q14289	Protein-tyrosine kinase 2-beta	RCA	20001213	PubMed	PTHR24418:SF94	PROTEIN-TYROSINE KINASE 2-BETA
P04393	Ras Pathway	P04558	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00551	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Ensembl=ENSCAFG00000013828|UniProtKB=P11617	Adenosine receptor A2a	IDA			PTHR24246:SF27	ADENOSINE RECEPTOR A2A
P04395	Vasopressin synthesis	P04589	Signal Peptidase	HUMAN|HGNC=17718|UniProtKB=P67812	Signal peptidase complex catalytic subunit SEC11A	IC	2092035	PubMed	PTHR10806:SF8	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11A-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00005	Angiogenesis	P00203	Erk	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01211	ERK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	IDA	94131269	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00018	EGF receptor signaling pathway	P00545	JNK1-3	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=107469|UniProtKB=Q8K3R3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	7822322	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00001	Adrenaline and noradrenaline biosynthesis	P00068	amine translocator	MOUSE|MGI=MGI=2442535|UniProtKB=Q8BJI1	Sodium-dependent neutral amino acid transporter SLC6A17	IC	12719981	PubMed	PTHR11616:SF102	SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER SLC6A17
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MACMU|Ensembl=ENSMMUG00000006200|UniProtKB=F7HNS7	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000014674|UniProtKB=P41985	Muscarinic acetylcholine receptor M2	ISS	12181435	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00021	FGF signaling pathway	P00647	SHP2	DROME|FlyBase=FBgn0000382|UniProtKB=P29349	Tyrosine-protein phosphatase corkscrew	IGI			PTHR19134:SF428	TYROSINE-PROTEIN PHOSPHATASE CORKSCREW
P00009	Axon guidance mediated by netrin	P00359	NFAT	CANLF|Ensembl=ENSCAFG00000011625|UniProtKB=F1PDD9	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00023	General transcription regulation	P00658	TBP-associated factors	XENTR|Xenbase=XB-GENE-491356|UniProtKB=Q28J24	Transcription initiation factor TFIID subunit 8	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00012	Cadherin signaling pathway	P00470	F-actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g210933|UniProtKB=A7SEA7	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02738	De novo purine biosynthesis	P02900	AICAR transformylase	SCHPO|PomBase=SPCPB16A4.03c|UniProtKB=O74928	Bifunctional purine biosynthesis protein ade10	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P00053	T cell activation	P01324	rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12874273	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04375	5HT3 type receptor mediated signaling pathway	P04425	K+ channel	MOUSE|MGI=MGI=1100509|UniProtKB=O35111	Potassium channel subfamily K member 3	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00059	p53 pathway	G01580	p21	HUMAN|HGNC=1784|UniProtKB=P38936	Cyclin-dependent kinase inhibitor 1	ISS			PTHR10265:SF16	CYCLIN-DEPENDENT KINASE INHIBITOR 1
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	IC	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01082	AC	PANTR|Ensembl=ENSPTRG00000001638|UniProtKB=H2Q0J3	Adenylate cyclase type 10	ISS	9874775	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P00005	Angiogenesis	P00249	PAK	RAT|RGD=61953|UniProtKB=Q64303	Serine/threonine-protein kinase PAK 2	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01471	alpha-catenin	XENTR|Xenbase=XB-GENE-479599|UniProtKB=F7DHT4	Uncharacterized protein	ISS	1768802	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DANRE|ZFIN=ZDB-GENE-000322-1|UniProtKB=Q9I8V1	Actin, alpha 1, skeletal muscle	ISS	14684598	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00029	Huntington disease	P00807	Actin	STRPU|EnsemblGenome=SPU_012282|UniProtKB=W4Y969	Uncharacterized protein	IDA	14684598	PubMed	PTHR11937:SF369	ACTIN-42A
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P05734	Synaptic vesicle trafficking	P05779	Synaptobrevin	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00034	Integrin signalling pathway	P00924	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01472	Histone deacetylase	BOVIN|Ensembl=ENSBTAG00000012698|UniProtKB=Q32PJ8	Histone deacetylase 1	ISS	12665570	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P00012	Cadherin signaling pathway	P00477	GSK3beta	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00054	Toll receptor signaling pathway	P01341	Elk1	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	14670631	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00907	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00036	Interleukin signaling pathway	P00996	STAT	HUMAN|HGNC=11362|UniProtKB=P42224	Signal transducer and activator of transcription 1-alpha/beta	IC	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00021	FGF signaling pathway	P00640	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DICDI|dictyBase=DDB_G0289489|UniProtKB=P07828	Actin-18	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	BOVIN|Ensembl=ENSBTAG00000030966|UniProtKB=Q58DG7	TBP-associated factor 6 isoform alpha	ISS			PTHR10221:SF12	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	TAS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00018	EGF receptor signaling pathway	P00547	PP2A	DANRE|ZFIN=ZDB-GENE-030904-6|UniProtKB=Q7ZUQ2	Ppp2r5e1 protein	ISS	8703017	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-030131-7595|UniProtKB=Q6PBR4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00006	Apoptosis signaling pathway	P00318	PKCs	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00208	MEKK1	MACMU|Ensembl=ENSMMUG00000012387|UniProtKB=F7EB20	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00006	Apoptosis signaling pathway	P00274	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	RCA	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MOUSE|MGI=MGI=104589|UniProtKB=P63268	Actin, gamma-enteric smooth muscle	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00048	PI3 kinase pathway	P01188	Gbetagamma	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01300	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00221	JNK1	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00048	PI3 kinase pathway	P01177	P110ACT	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00920	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	ARATH|TAIR=AT1G54960|UniProtKB=Q9FZ36	Mitogen-activated protein kinase kinase kinase 2	ISS			PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00057	Wnt signaling pathway	P01465	Ggamma	XENTR|Xenbase=XB-GENE-961282|UniProtKB=Q6DF43	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01307	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00034	Integrin signalling pathway	P00925	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IDA	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00021	FGF signaling pathway	P00624	14-3-3	DANRE|ZFIN=ZDB-GENE-011115-1|UniProtKB=Q6PC29	14-3-3 protein gamma-1	ISS	9507245	gi	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00048	PI3 kinase pathway	P01202	p85	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	TAKRU|Ensembl=ENSTRUG00000015959|UniProtKB=H2UV27	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00021	FGF signaling pathway	P00627	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	18479080	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	HUMAN|HGNC=4648|UniProtKB=Q00403	Transcription initiation factor IIB	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	IC	8838325	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05731	GABA-B receptor II signaling	P05755	Gbeta	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	RCA	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00019	Endothelin signaling pathway	P00588	ET1-4	MACMU|Ensembl=ENSMMUG00000007263|UniProtKB=F7FGG2	Preproendothelin-1	ISS	15117818	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-486685|UniProtKB=F6VT32	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00053	T cell activation	P01332	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00363	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01215	Syntaxin	BOVIN|Ensembl=ENSBTAG00000001192|UniProtKB=A7MAZ2	STX12 protein	ISS	14570579	PubMed	PTHR19957:SF88	SYNTAXIN-12
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	ARATH|TAIR=AT5G07880|UniProtKB=Q9SD96	SNAP25 homologous protein SNAP29	IC			PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04398	p53 pathway feedback loops 2	P04665	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	IDA	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008026|UniProtKB=H2QAZ2	Syntaxin 1B	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	ORNAN|Ensembl=ENSOANG00000000818|UniProtKB=F6PLI7	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00029	Huntington disease	P00790	beta-Tubulin	IXOSC|EnsemblGenome=ISCW021482|UniProtKB=B7Q717	Beta-tubulin, putative (Fragment)	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00047	PDGF signaling pathway	P01160	IP3 receptor	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00053	T cell activation	P01311	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00017	DNA replication	P00527	Histones	STRPU|EnsemblGenome=SPU_000464|UniProtKB=H3I1F0	Histone H3	ISS	12413958	PubMed	PTHR11426:SF20	HISTONE H3-LIKE CENTROMERIC PROTEIN A
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04395	Vasopressin synthesis	P04597	Signal Peptide	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IDA	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00148	Erb-B4 N-terminal fragment	CHICK|Ensembl=ENSGALG00000003126|UniProtKB=F1P258	Receptor protein-tyrosine kinase	ISS	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00005	Angiogenesis	P00226	Delta/Serrate	CANLF|Ensembl=ENSCAFG00000005627|UniProtKB=E2QUR0	Delta-like protein	ISS	10551863	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00006	Apoptosis signaling pathway	P00269	MAPK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00778	NMDA receptor	DANRE|ZFIN=ZDB-GENE-051202-2|UniProtKB=Q6ZM67	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF3	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=4596|UniProtKB=Q14833	Metabotropic glutamate receptor 4	IDA	9407094	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=29822|UniProtKB=Q9Y6X6	Unconventional myosin-XVI	IC			PTHR13140:SF345	UNCONVENTIONAL MYOSIN-XVI
P00034	Integrin signalling pathway	P00922	Collagen	HUMAN|HGNC=2197|UniProtKB=P02452	Collagen alpha-1(I) chain	IDA	10778855	PubMed	PTHR24023:SF569	COLLAGEN ALPHA-1 I  CHAIN
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	BOVIN|Ensembl=ENSBTAG00000018245|UniProtKB=P46411	Excitatory amino acid transporter 1	IC	94365697	PubMed	PTHR11958:SF24	EXCITATORY AMINO ACID TRANSPORTER 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000024992|UniProtKB=F6TUR3	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00057	Wnt signaling pathway	P01458	Protein Kinase C	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00059	p53 pathway	P04609	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00729	Goalpha	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	ORNAN|Ensembl=ENSOANG00000010187|UniProtKB=F7E0A0	Uncharacterized protein	ISS	10321247	PubMed	PTHR19957:SF90	SYNTAXIN-7
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MOUSE|MGI=MGI=108476|UniProtKB=Q61086	Frizzled-3	TAS	11212302	PubMed	PTHR11309:SF22	FRIZZLED-3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	DROME|FlyBase=FBgn0003416|UniProtKB=Q9VXH3	Phosphoinositide phospholipase C	ISS			PTHR10336:SF91	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00046	Oxidative stress response	P01131	MKP5	CAEBR|Gene=CBG03773|UniProtKB=A8WWP5	Protein CBG03773	ISS			PTHR10159:SF378	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00555	MKK4,7	MOUSE|MGI=MGI=1346869|UniProtKB=P47809	Dual specificity mitogen-activated protein kinase kinase 4	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00010	B cell activation	P00383	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	ORNAN|Ensembl=ENSOANG00000000460|UniProtKB=F7F4W9	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	BOVIN|Ensembl=ENSBTAG00000020756|UniProtKB=A6QLB8	GSK3A protein	ISS	183955	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TRIVA|Gene=TVAG_054030|UniProtKB=A2G1K5	Actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	8132661	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P04398	p53 pathway feedback loops 2	P04658	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00056	VEGF signaling pathway	P01417	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00111	C99	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00060	Ubiquitin proteasome pathway	P01491	E2	HUMAN|HGNC=31710|UniProtKB=Q5JXB2	Putative ubiquitin-conjugating enzyme E2 N-like	ISS			PTHR43902:SF3	UBIQUITIN-CONJUGATING ENZYME E2 N-LIKE-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01395	TFIIE	CAEEL|WormBase=WBGene00010054|UniProtKB=G5EG47	Transcription initiation factor IIE subunit beta	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P00055	Transcription regulation by bZIP transcription factor	P01390	TFIIA complex	NEUCR|EnsemblGenome=EFNCRG00000009491|UniProtKB=Q7SEH7	Transcription initiation factor IIA subunit 2	ISS	95241493	PubMed	PTHR10966:SF0	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MONDO|Ensembl=ENSMODG00000005136|UniProtKB=F7EQH3	Uncharacterized protein (Fragment)	ISS	5031595	gi	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	ORNAN|Gene=WNT2|UniProtKB=Q07DZ8	Protein Wnt-2	ISS	11266476	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00029	Huntington disease	P00780	Microtubule	PRIPA|Gene=PPA21756|UniProtKB=H3FHK9	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF255	TUBA7L PROTEIN
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00046	Oxidative stress response	P01132	c-jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	8837781	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IDA	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00019	Endothelin signaling pathway	P00589	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01188	Gbetagamma	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00057	Wnt signaling pathway	P01455	Smad4	ORNAN|Ensembl=ENSOANG00000006538|UniProtKB=F6YA42	Mothers against decapentaplegic homolog	ISS	12736218	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04455	beta-endorphin	DANRE|ZFIN=ZDB-GENE-030513-2|UniProtKB=Q7ZT18	Pro-opiomelanocortin protein	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	ORYSJ|EnsemblGenome=OS07G0492000|UniProtKB=Q07661	Nucleoside diphosphate kinase 1	ISS			PTHR11349:SF66	SUBFAMILY NOT NAMED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TAKRU|Ensembl=ENSTRUG00000007989|UniProtKB=P68140	Actin, alpha skeletal muscle A	IC	11889126	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	11204774	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	BOVIN|Ensembl=ENSBTAG00000021837|UniProtKB=Q08DC7	Regulator of G-protein signaling 19	ISS	8756726	PubMed	PTHR10845:SF145	REGULATOR OF G-PROTEIN SIGNALING 19
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12912997	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05938	RhoA	XENTR|Xenbase=XB-GENE-941426|UniProtKB=Q28HZ4	Novel Rho protein	ISS	15668138	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00006	Apoptosis signaling pathway	P00310	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	IDA	10799299	PubMed	PTHR10048:SF14	PI-3 KINASE
P00010	B cell activation	P00371	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04395	Vasopressin synthesis	P04599	Amidating Enzyme	CAEEL|WormBase=WBGene00017671|UniProtKB=P91268	Probable peptidyl-alpha-hydroxyglycine alpha-amidating lyase pgal-1	IC	3153462	PubMed	PTHR10680:SF25	PEPTIDYL-ALPHA-HYDROXYGLYCINE ALPHA-AMIDATING LYASE PGAL-1-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_115566|UniProtKB=C3XYC8	Putative uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	BOVIN|Ensembl=ENSBTAG00000014583|UniProtKB=P62157	Calmodulin	ISS	10487978	PubMed	PTHR23050:SF335	CALMODULIN, STRIATED MUSCLE
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	MACMU|Ensembl=ENSMMUG00000029428|UniProtKB=F7GPI8	Uncharacterized protein	ISS			PTHR43720:SF2	ALDEHYDE DEHYDROGENASE FAMILY 8 MEMBER A1
P00003	Alzheimer disease-amyloid secretase pathway	P00095	Nicastrin	CANLF|Ensembl=ENSCAFG00000012557|UniProtKB=F1PU73	Uncharacterized protein	ISS	10993067	PubMed	PTHR21092:SF0	NICASTRIN
P02785	Valine biosynthesis	P03215	Branched chain amino acid aminotransferase	BACSU|EnsemblGenome=BSU02390|UniProtKB=O31461	Branched-chain-amino-acid transaminase 1	ISS			PTHR11825:SF44	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	IC	176892	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00059	p53 pathway	P04635	Sumo-1 ligase	HUMAN|HGNC=11124|UniProtKB=P55854	Small ubiquitin-related modifier 3	ISS			PTHR10562:SF50	SMALL UBIQUITIN-RELATED MODIFIER 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P06959	CCKR signaling map	P07117	BCL2L1	HUMAN|HGNC=992|UniProtKB=Q07817	Bcl-2-like protein 1	RCA	17936584	PubMed	PTHR11256:SF12	BCL-2-LIKE PROTEIN 1
P00019	Endothelin signaling pathway	P00576	Pre-pro ET1-4	BOVIN|Ensembl=ENSBTAG00000008096|UniProtKB=P17322	Endothelin-1	ISS			PTHR13874:SF10	ENDOTHELIN-1
P02734	Chorismate biosynthesis	P02873	Shikimate dehydrogenase	GLOVI|Gene=BAC91219|UniProtKB=Q7NG95	Shikimate dehydrogenase (NADP(+))	ISS			PTHR21089:SF1	BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE/SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MONDO|Ensembl=ENSMODG00000016287|UniProtKB=F7AU53	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF63	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DANRE|ZFIN=ZDB-GENE-030131-1229|UniProtKB=Q6DHS1	Actin, alpha 2, smooth muscle, aorta	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	MACMU|Ensembl=ENSMMUG00000013100|UniProtKB=F6ZUP6	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF4	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4
P00010	B cell activation	P00368	vav	HUMAN|HGNC=12658|UniProtKB=P52735	Guanine nucleotide exchange factor VAV2	IGI	14623913	PubMed	PTHR22826:SF95	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV2
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=103077|UniProtKB=Q64704	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IDA	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00037	Ionotropic glutamate receptor pathway	P01015	Glu4	RAT|RGD=61863|UniProtKB=P19493	Glutamate receptor 4	ISS	12871085	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	PSEAE|EnsemblGenome=PA4976|UniProtKB=Q9HUI9	Arginine--pyruvate transaminase AruH	ISS			PTHR11751:SF306	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	MACMU|Ensembl=ENSMMUG00000003370|UniProtKB=F7E8G2	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	RAT|RGD=628850|UniProtKB=B1WBR9	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P02738	De novo purine biosynthesis	P02902	ADP reductase	XENTR|Xenbase=XB-GENE-1014077|UniProtKB=F6TKJ2	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	HUMAN|HGNC=144|UniProtKB=P63261	Actin, cytoplasmic 2	IDA	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00053	T cell activation	P01322	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00019	Endothelin signaling pathway	P00591	PLCbeta	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	IDA	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=105372|UniProtKB=P49660	Somatostatin receptor type 4	IDA	12441358	PubMed	PTHR24229:SF52	SOMATOSTATIN RECEPTOR TYPE 4
P00005	Angiogenesis	P00231	HSP27	HUMAN|HGNC=5246|UniProtKB=P04792	Heat shock protein beta-1	IDA			PTHR11527:SF114	HEAT SHOCK PROTEIN BETA-1
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00023	General transcription regulation	P00670	TBP	PANTR|Ensembl=ENSPTRG00000018624|UniProtKB=A6H914	TATA box binding protein-like 1	ISS	600075	OMIM	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	RAT|RGD=620977|UniProtKB=G3V7P1	Syntaxin-12	ISS	10321247	PubMed	PTHR19957:SF88	SYNTAXIN-12
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00018	EGF receptor signaling pathway	P00559	MEK1-2	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05917	Opioid proopiomelanocortin pathway	P06004	Mu or Delta receptor	PANTR|Ensembl=ENSPTRG00000000440|UniProtKB=H2PYH8	Uncharacterized protein	ISS	11259498	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	ARATH|TAIR=AT5G61210|UniProtKB=Q9S7P9	SNAP25 homologous protein SNAP33	IC			PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IDA	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05731	GABA-B receptor II signaling	P05754	Ggamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P05917	Opioid proopiomelanocortin pathway	P06011	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00019	Endothelin signaling pathway	P00568	PKC	SCHPO|PomBase=SPAC17G8.14c|UniProtKB=P36582	Protein kinase C-like 1	IGI	8491190	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04393	Ras Pathway	P04542	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00392	I kappa B	MOUSE|MGI=MGI=104741|UniProtKB=Q9Z1E3	NF-kappa-B inhibitor alpha	ISS	14665694	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	RAT|RGD=2746|UniProtKB=P31424	Metabotropic glutamate receptor 5	ISS	9407094	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	CANLF|Ensembl=ENSCAFG00000004956|UniProtKB=E2REH3	Uncharacterized protein	ISS	14580336	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	IC	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00223	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06011	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	ISS	96149441	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00034	Integrin signalling pathway	P00921	PINCH	CHICK|Ensembl=ENSGALG00000016807|UniProtKB=F1NZW4	Uncharacterized protein	ISS	10022929	PubMed	PTHR24210:SF11	LIM AND SENESCENT CELL ANTIGEN-LIKE-CONTAINING DOMAIN PROTEIN 1-RELATED
P02769	Purine metabolism	P03118	Guanine Deaminase	MACMU|Ensembl=ENSMMUG00000019196|UniProtKB=F7CWS1	Guanine deaminase isoform b	ISS	11962625	PubMed	PTHR11271:SF6	GUANINE DEAMINASE
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	NEUCR|EnsemblGenome=EFNCRG00000001936|UniProtKB=Q7SG85	Glutamine synthetase	ISS			PTHR43785:SF1	TYPE-1 GLUTAMINE SYNTHETASE 2
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000018684|UniProtKB=C7G3M7	Glutamate receptor, metabotropic 1	ISS			PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P06959	CCKR signaling map	P07028	SHP-2	HUMAN|HGNC=9644|UniProtKB=Q06124	Tyrosine-protein phosphatase non-receptor type 11	RCA	16963136	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	PANTR|Ensembl=ENSPTRG00000006510|UniProtKB=H2Q8K1	Presenilin	ISS	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05731	GABA-B receptor II signaling	P05753	Ca channel	HUMAN|HGNC=1389|UniProtKB=Q00975	Voltage-dependent N-type calcium channel subunit alpha-1B	TAS	14624853	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00049	Parkinson disease	P01211	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06779	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	RCA	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00544	c-Cbl	MACMU|Ensembl=ENSMMUG00000004761|UniProtKB=F6SMS3	E3 ubiquitin-protein ligase CBL	ISS	6680858	gi	PTHR23007:SF5	E3 UBIQUITIN-PROTEIN LIGASE CBL
P00019	Endothelin signaling pathway	P00586	Gq	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00004	Alzheimer disease-presenilin pathway	P00114	actin	SCHMA|EnsemblGenome=Smp_046600|UniProtKB=G4VLW2	Putative actin-1	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00107	kinesin	HUMAN|HGNC=20716|UniProtKB=Q9H0B6	Kinesin light chain 2	IDA	11740561	PubMed	PTHR19959:SF177	KINESIN LIGHT CHAIN 2
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MACMU|Ensembl=ENSMMUG00000001124|UniProtKB=F6TA61	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF6	INHIBIN BETA E CHAIN
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01162	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	MONDO|Ensembl=ENSMODG00000010167|UniProtKB=F6TA59	Uncharacterized protein	ISS	11055438	PubMed	PTHR10117:SF25	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 4
P00054	Toll receptor signaling pathway	P01375	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IGI	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8971|UniProtKB=O00443	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	IPI	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00049	Parkinson disease	P01219	SAPK	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	NAS	10851062	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00828	Galphai	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	RCA			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	P01444	Wnt	TAKRU|Ensembl=ENSTRUG00000007912|UniProtKB=H2T4W3	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF83	PROTEIN WNT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04558	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MOUSE|MGI=MGI=104558|UniProtKB=P18653	Ribosomal protein S6 kinase alpha-1	ISS	15226426	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	CAEBR|Gene=CBG17302|UniProtKB=A8XQS8	Protein CBR-MIG-2	ISS			PTHR24072:SF157	AT17867P
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CAEEL|WormBase=WBGene00000063|UniProtKB=P0DM41	Actin-1	ISS	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05994	G-protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00059	p53 pathway	P04609	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00759	PDEalphabeta	RAT|RGD=1311039|UniProtKB=D3ZDI8	Phosphodiesterase	ISS	P35913	SPACC	PTHR11347:SF73	ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT BETA
P00005	Angiogenesis	P00203	Erk	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00038	JAK/STAT signaling pathway	P01027	STAT	DANRE|ZFIN=ZDB-GENE-980526-499|UniProtKB=Q6P943	Signal transducer and activator of transcription	ISS	10417824	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00036	Interleukin signaling pathway	P00975	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	227170	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00168	E-cadherin intracellular fragment	HUMAN|HGNC=1762|UniProtKB=P22223	Cadherin-3	IDA	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000002016|UniProtKB=F1P3G1	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	RCA	1504106	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	RCA	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00025	Hedgehog signaling pathway	P00692	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00060	Ubiquitin proteasome pathway	P01491	E2	ORNAN|Ensembl=ENSOANG00000004612|UniProtKB=F7G1C1	Uncharacterized protein	ISS			PTHR24068:SF36	UBIQUITIN-CONJUGATING ENZYME E2 D1
P00019	Endothelin signaling pathway	P00566	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	13620175	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	TAKRU|Ensembl=ENSTRUG00000016101|UniProtKB=H2UW32	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00047	PDGF signaling pathway	P01142	p90RSK	ORNAN|Ensembl=ENSOANG00000002226|UniProtKB=F6TPX7	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEEL|WormBase=WBGene00004033|UniProtKB=P90980	Protein kinase C-like 2	ISS	3755548	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IDA	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	RCA	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MOUSE|MGI=MGI=1339712|UniProtKB=P13542	Myosin-8	IEP	89264452	PubMed	PTHR13140:SF368	MYOSIN-8
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347740|UniProtKB=E9FXV8	Cytoplasmatic actin	ISS	14684598	PubMed	PTHR11937:SF277	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MOUSE|MGI=MGI=108450|UniProtKB=P51830	Adenylate cyclase type 9	ISS	2491850	PubMed	PTHR11920:SF319	ADENYLATE CYCLASE TYPE 9
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00539	14-3-3	DANRE|ZFIN=ZDB-GENE-011115-1|UniProtKB=Q6PC29	14-3-3 protein gamma-1	ISS	1317796	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00049	Parkinson disease	P01242	Casein kinase I	ARATH|TAIR=AT4G28880|UniProtKB=Q93Z18	Protein CASEIN KINASE I-LIKE 3	IDA	10617630	PubMed	PTHR11909:SF97	PROTEIN CASEIN KINASE I-LIKE 3-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	IC	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04393	Ras Pathway	P04542	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TRIVA|Gene=TVAG_090470|UniProtKB=A2FA04	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	TAS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01402	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	RCA			PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00025	Hedgehog signaling pathway	P00682	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05915	Opioid proenkephalin pathway	P05985	Mu or Delta receptor	MOUSE|MGI=MGI=97438|UniProtKB=P32300	Delta-type opioid receptor	RCA	11259487	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000022513|UniProtKB=F6YNZ0	Uncharacterized protein	ISS	20012997	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00587	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01185	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	PANTR|Ensembl=ENSPTRG00000002706|UniProtKB=H2Q272	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P00029	Huntington disease	P00780	Microtubule	HUMAN|HGNC=30829|UniProtKB=Q9BVA1	Tubulin beta-2B chain	IDA	12932731	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00021	FGF signaling pathway	P00647	SHP2	DANRE|ZFIN=ZDB-GENE-030131-5911|UniProtKB=F1QZU5	Tyrosine-protein phosphatase non-receptor type	ISS	8096088	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	DICDI|dictyBase=DDB_G0269102|UniProtKB=O96625	Actin-related protein 2/3 complex subunit 4	ISS	5031595	gi	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00029	Huntington disease	P00799	JNK-2	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00029	Huntington disease	P00778	NMDA receptor	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00718	Phosphorylase a	HUMAN|HGNC=9725|UniProtKB=P06737	Glycogen phosphorylase, liver form	IDA	4318782	PubMed	PTHR11468:SF12	GLYCOGEN PHOSPHORYLASE, LIVER FORM
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	TAS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00018	EGF receptor signaling pathway	P00557	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IGI	14526383	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00010	B cell activation	P00384	p38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IDA	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00029	Huntington disease	P00790	beta-Tubulin	ORYSJ|EnsemblGenome=OS03G0661300|UniProtKB=Q76FS2	Tubulin beta-8 chain	TAS	12932731	PubMed	PTHR11588:SF246	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00053	T cell activation	P01318	PKC-theta	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00057	Wnt signaling pathway	P01428	Frizzled	RAT|RGD=61916|UniProtKB=Q08463	Frizzled-1	IDA	12549854	PubMed	PTHR11309:SF81	FRIZZLED-1
P00034	Integrin signalling pathway	P00921	PINCH	RAT|RGD=1305273|UniProtKB=A0A0G2KAE1	Protein Lims2	ISS	10022929	PubMed	PTHR24210:SF10	LIM AND SENESCENT CELL ANTIGEN-LIKE-CONTAINING DOMAIN PROTEIN 2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000010953|UniProtKB=F1Q376	Phosphoinositide phospholipase C	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00034	Integrin signalling pathway	P00927	Rac	DROME|FlyBase=FBgn0010333|UniProtKB=P40792	Ras-related protein Rac1	IGI	4757952	gi	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00944	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g210933|UniProtKB=A7SEA7	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00025	Hedgehog signaling pathway	P00692	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00052	TGF-beta signaling pathway	P01275	P38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	TAS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P02783	Tryptophan biosynthesis	P03208	Tryptophan synthase B	METAC|EnsemblGenome=MA_2991|UniProtKB=Q8TLP3	Tryptophan synthase beta chain 1	ISS			PTHR42882:SF1	TRYPTOPHAN SYNTHASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	IC	14765990	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00006	Apoptosis signaling pathway	P00271	Bax	RAT|RGD=2192|UniProtKB=Q63690	Apoptosis regulator BAX	ISS	11099028	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P00038	JAK/STAT signaling pathway	P01030	SOCS	MACMU|Ensembl=ENSMMUG00000010956|UniProtKB=F7GGH3	Uncharacterized protein	ISS			PTHR44621:SF2	SUPPRESSOR OF CYTOKINE SIGNALING 1
P00005	Angiogenesis	P00203	Erk	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00060	Ubiquitin proteasome pathway	P01491	E2	BOVIN|Ensembl=ENSBTAG00000014433|UniProtKB=A2VE20	UBE2G1 protein	ISS			PTHR24067:SF3	UBIQUITIN-CONJUGATING ENZYME E2 G1
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	IDA	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	STRPU|EnsemblGenome=SPU_018419|UniProtKB=W4YRI6	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00005	Angiogenesis	P00195	APC	MOUSE|MGI=MGI=88039|UniProtKB=Q61315	Adenomatous polyposis coli protein	ISS	12549854	PubMed	PTHR12607:SF11	ADENOMATOUS POLYPOSIS COLI PROTEIN
P00048	PI3 kinase pathway	P01185	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12176041	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	STRPU|EnsemblGenome=SPU_026078|UniProtKB=W4ZD41	Uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF277	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00010	B cell activation	P00376	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00034	Integrin signalling pathway	P00916	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00007	Axon guidance mediated by semaphorins	P00341	Rho	MONDO|Ensembl=ENSMODG00000012981|UniProtKB=F7CS91	Uncharacterized protein	ISS	11360179	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IDA	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00005	Angiogenesis	P00210	eNOS	MACMU|Ensembl=ENSMMUG00000020437|UniProtKB=F6WEB2	Nitric oxide synthase	ISS	10435050	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00054	Toll receptor signaling pathway	P01353	TANK	PANTR|Ensembl=ENSPTRG00000012574|UniProtKB=H2QIV9	TRAF family member-associated NFKB activator	ISS			PTHR15249:SF0	TRAF FAMILY MEMBER-ASSOCIATED NF-KAPPA-B ACTIVATOR
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	ISS	8787761	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00925	MEK	BOVIN|Ensembl=ENSBTAG00000010576|UniProtKB=A4IFH7	MAP2K3 protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00127	APP	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00046	Oxidative stress response	P01134	cPLA2	RAT|RGD=67366|UniProtKB=P50393	Cytosolic phospholipase A2	TAS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00539	14-3-3	MACMU|Ensembl=ENSMMUG00000009945|UniProtKB=F6RIX6	14-3-3 protein eta	ISS	10407019	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00029	Huntington disease	P00778	NMDA receptor	RAT|RGD=2740|UniProtKB=Q62645	Glutamate receptor ionotropic, NMDA 2D	IDA	11319238	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	10669416	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00060	Ubiquitin proteasome pathway	P01490	E3	MOUSE|MGI=MGI=98890|UniProtKB=Q02053	Ubiquitin-like modifier-activating enzyme 1	ISS			PTHR10953:SF155	UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 1
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	CHICK|Ensembl=ENSGALG00000028102|UniProtKB=F1P3X4	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF657	MYOSIN-4
P00005	Angiogenesis	P00203	Erk	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	IDA	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00021	FGF signaling pathway	P00647	SHP2	MONDO|Ensembl=ENSMODG00000003120|UniProtKB=F6WVD2	Tyrosine-protein phosphatase non-receptor type	ISS	1382983	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00015	Circadian clock system	G01499	per	PANTR|Ensembl=ENSPTRG00000008726|UniProtKB=H2QC70	Uncharacterized protein	ISS	12782655	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00830	Lipoxygenase	MACMU|Ensembl=ENSMMUG00000016264|UniProtKB=F7GAZ2	Uncharacterized protein	ISS	12432925	PubMed	PTHR11771:SF4	ARACHIDONATE 12-LIPOXYGENASE, 12S-TYPE
P00049	Parkinson disease	P01219	SAPK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	NAS	10514528	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00019	Endothelin signaling pathway	P00591	PLCbeta	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00049	Parkinson disease	P01238	14-3-3	HUMAN|HGNC=12849|UniProtKB=P31946	14-3-3 protein beta/alpha	IDA	12618428	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00045	Notch signaling pathway	P01101	Su(H)	HUMAN|HGNC=5724|UniProtKB=Q06330	Recombining binding protein suppressor of hairless	ISS	12145413	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P04393	Ras Pathway	P04567	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01171	PLCgamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00748	Gbeta5L	PANTR|Ensembl=ENSPTRG00000007084|UniProtKB=H2Q9G5	Uncharacterized protein	ISS	10051575	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	IDA	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	DANRE|ZFIN=ZDB-GENE-991207-24|UniProtKB=Q9PVF8	Catenin (Cadherin-associated protein), alpha	TAS	10456847	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P02725	Allantoin degradation	P02821	Allantoate amidohydrolase	PANTR|Ensembl=ENSPTRG00000011618|UniProtKB=H2QHD7	Uncharacterized protein	ISS			PTHR12045:SF3	ALLANTOICASE-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00034	Integrin signalling pathway	P00907	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04553	PAK	CHICK|Ensembl=ENSGALG00000006426|UniProtKB=E1BS97	Uncharacterized protein	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00019	Endothelin signaling pathway	P00591	PLCbeta	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00029	Huntington disease	P00778	NMDA receptor	RAT|RGD=2739|UniProtKB=Q00961	Glutamate receptor ionotropic, NMDA 2C	IDA	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00054	Toll receptor signaling pathway	P01345	IKKalpha	HUMAN|HGNC=1974|UniProtKB=O15111	Inhibitor of nuclear factor kappa-B kinase subunit alpha	ISS	14499113	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00010	B cell activation	P00402	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P06664	Gonadotropin-releasing hormone receptor pathway	P06777	NFAT	MOUSE|MGI=MGI=1920431|UniProtKB=Q8K120	Nuclear factor of activated T-cells, cytoplasmic 4	RCA	9133421	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00029	Huntington disease	P00796	Kainate receptor	MONDO|Ensembl=ENSMODG00000018065|UniProtKB=F7G485	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00034	Integrin signalling pathway	P00923	Arf1	XENTR|Xenbase=XB-GENE-961332|UniProtKB=Q5BJ82	ADP-ribosylation factor-like 1	ISS	12932731	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P00048	PI3 kinase pathway	P01181	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00005	Angiogenesis	P00254	GTPase	HUMAN|HGNC=669|UniProtKB=P08134	Rho-related GTP-binding protein RhoC	ISS	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P06664	Gonadotropin-releasing hormone receptor pathway	P06853	PEA-15	MOUSE|MGI=MGI=104799|UniProtKB=Q62048	Astrocytic phosphoprotein PEA-15	RCA			PTHR15094:SF0	ASTROCYTIC PHOSPHOPROTEIN PEA-15
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	SCHMA|EnsemblGenome=Smp_183710|UniProtKB=G4VLW1	Putative actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00552	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00005	Angiogenesis	P00249	PAK	CHICK|Ensembl=ENSGALG00000006426|UniProtKB=E1BS97	Uncharacterized protein	ISS	10644687	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P02729	Ascorbate degradation	P02852	L-xylulose-5-phosphate-3-epimerase	DANRE|ZFIN=ZDB-GENE-030131-6837|UniProtKB=Q6PBW9	Ribulose-phosphate 3-epimerase	ISS			PTHR11749:SF3	RIBULOSE-PHOSPHATE 3-EPIMERASE
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IPI	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MONDO|Ensembl=ENSMODG00000023942|UniProtKB=F7F878	Uncharacterized protein	ISS	12181435	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P00049	Parkinson disease	P01242	Casein kinase I	ORNAN|Ensembl=ENSOANG00000010562|UniProtKB=F6TBG4	Uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00018	EGF receptor signaling pathway	P00564	Rac	ENTHI|EnsemblGenome=EHI_129750|UniProtKB=C4M5Q7	Rho family GTPase	IGI	4757952	gi	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01457	GBeta	ANOGA|EnsemblGenome=AGAP005913|UniProtKB=Q7Q6D2	AGAP005913-PA	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IGI	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05913	Enkephalin release	P05977	G-Protein (s)	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	RAT|RGD=1588606|UniProtKB=D4A8A0	DNA fragmentation factor subunit beta	ISS			PTHR11405:SF5	CAD PROTEIN
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	BOVIN|Ensembl=ENSBTAG00000013047|UniProtKB=E1BLE8	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00060	Ubiquitin proteasome pathway	P01491	E2	LEIMA|EnsemblGenome=LmjF.04.0680|UniProtKB=Q9NED4	Putative ubiquitin-conjugating enzyme e2	ISS			PTHR43902:SF2	UBIQUITIN-CONJUGATING ENZYME E2 N
P00007	Axon guidance mediated by semaphorins	P00340	Rac	MACMU|Ensembl=ENSMMUG00000021075|UniProtKB=F7GY91	Uncharacterized protein	ISS	11756405	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05917	Opioid proopiomelanocortin pathway	P06010	proopiomelanocortin	BOVIN|Ensembl=ENSBTAG00000007897|UniProtKB=P01190	Pro-opiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01219	SAPK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	NAS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	PANTR|Ensembl=ENSPTRG00000014356|UniProtKB=H2QLN0	Polymerase (RNA) II (DNA directed) polypeptide F	ISS	415387	gi	PTHR10773:SF12	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2
P00053	T cell activation	P01312	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02753	Methionine biosynthesis	P03024	Homocysteine transmethylase	MYCTU|EnsemblGenome=Rv2124c|UniProtKB=O33259	Methionine synthase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P00029	Huntington disease	P00772	FIP-2	MOUSE|MGI=MGI=2147191|UniProtKB=Q921Z5	Tumor necrosis factor alpha-induced protein 8	ISS			PTHR12757:SF3	TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 8
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04393	Ras Pathway	P04558	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IDA	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02785	Valine biosynthesis	P03215	Branched chain amino acid aminotransferase	RAT|RGD=2195|UniProtKB=P54690	Branched-chain-amino-acid aminotransferase, cytosolic	ISS			PTHR11825:SF51	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, CYTOSOLIC
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02763	Peptidoglycan biosynthesis	P03086	N-acetylglucosamine-1-phosphate uridyltransferase	SYNY3|EnsemblGenome=BAA10856|UniProtKB=Q55504	Bifunctional protein GlmU	ISS			PTHR43584:SF3	BIFUNCTIONAL PROTEIN GLMU
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00006	Apoptosis signaling pathway	P00260	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	PANTR|Ensembl=ENSPTRG00000005122|UniProtKB=H2Q6A6	Uncharacterized protein	ISS	11907044	PubMed	PTHR44025:SF2	PROLOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1
P00018	EGF receptor signaling pathway	P00562	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00004	Alzheimer disease-presenilin pathway	P00121	CD44 intracellular fragment	HUMAN|HGNC=1681|UniProtKB=P16070	CD44 antigen	IDA	12223485	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P00059	p53 pathway	P04623	CBP	HUMAN|HGNC=3373|UniProtKB=Q09472	Histone acetyltransferase p300	IDA	10664585	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2518|UniProtKB=P18901	D(1A) dopamine receptor	IDA			PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01227	20S proteasome	TRYB2|Gene=Tb09.211.2590|UniProtKB=Q38DP7	Proteasome subunit beta type	ISS	12859888	PubMed	PTHR11599:SF44	AT05866P-RELATED
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	CHICK|Ensembl=ENSGALG00000012444|UniProtKB=Q90669	Activin receptor type-2A	TAS	9395284	PubMed	PTHR23255:SF64	ACTIVIN RECEPTOR TYPE-2A
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	MOUSE|MGI=MGI=97515|UniProtKB=Q04592	Proprotein convertase subtilisin/kexin type 5	IDA			PTHR42884:SF7	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 5
P00001	Adrenaline and noradrenaline biosynthesis	P00065	DAT	RAT|RGD=3715|UniProtKB=P23977	Sodium-dependent dopamine transporter	ISS	15135042	PubMed	PTHR11616:SF38	SODIUM-DEPENDENT DOPAMINE TRANSPORTER
P00052	TGF-beta signaling pathway	P01289	I-Smads	RAT|RGD=1305069|UniProtKB=D3ZAQ2	Mothers against decapentaplegic homolog	ISS	9335505	PubMed	PTHR13703:SF28	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 6
P00053	T cell activation	P01322	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00011	Blood coagulation	P00437	Kallikrein	RAT|RGD=67382|UniProtKB=P14272	Plasma kallikrein	ISS	20072342	gi	PTHR44459:SF2	PLASMA KALLIKREIN
P00047	PDGF signaling pathway	P01143	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1718748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	YEAST|SGD=S000000201|UniProtKB=P24583	Protein kinase C-like 1	IC	125549	gi	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00059	p53 pathway	P04630	PP2A	MOUSE|MGI=MGI=1321159|UniProtKB=P63330	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	MONDO|Ensembl=ENSMODG00000014746|UniProtKB=F6YN64	Uncharacterized protein (Fragment)	ISS	12497607	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	TAKRU|Ensembl=ENSTRUG00000006502|UniProtKB=H2SU27	Uncharacterized protein	IDA	11781138	PubMed	PTHR24248:SF24	ALPHA-2A ADRENERGIC RECEPTOR
P00010	B cell activation	P00386	Calcineurin	MOUSE|MGI=MGI=107164|UniProtKB=P63328	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	ISS	12015605	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00059	p53 pathway	G04694	p110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00477	GSK3beta	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	IDA	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00107	kinesin	RAT|RGD=1306555|UniProtKB=Q5PQM2	Kinesin light chain 4	ISS	11740561	PubMed	PTHR19959:SF139	KINESIN LIGHT CHAIN 4
P00012	Cadherin signaling pathway	P00475	Frizzled	MOUSE|MGI=MGI=108570|UniProtKB=Q61090	Frizzled-7	IDA	8717036	PubMed	PTHR11309:SF31	FRIZZLED-7
P04395	Vasopressin synthesis	P04594	Neurophysin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00005	Angiogenesis	P00208	MEKK1	RAT|RGD=620966|UniProtKB=Q62925	Mitogen-activated protein kinase kinase kinase 1	ISS	12168099	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	SCHPO|PomBase=SPAC144.03|UniProtKB=Q02787	Adenylosuccinate synthetase	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P02746	Heme biosynthesis	P02979	porphobilinogen synthase	DEIRA|EnsemblGenome=DR_2160|UniProtKB=Q9RSG4	Delta-aminolevulinic acid dehydratase	ISS			PTHR11458:SF0	DELTA-AMINOLEVULINIC ACID DEHYDRATASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IPI	12707323	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IGI	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P02751	Lysine biosynthesis	P03007	Diaminopimelate decarboxylase	DICDI|dictyBase=DDB_G0276067|UniProtKB=Q75JL7	Uncharacterized protein	ISS			PTHR43727:SF3	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	TAS	12701063	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00010	B cell activation	P00398	IP3R	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04397	p53 pathway by glucose deprivation	P04641	Akt	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00542	EGFR	RAT|RGD=620486|UniProtKB=Q62956	Receptor tyrosine-protein kinase erbB-4	IGI	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	HUMAN|HGNC=16833|UniProtKB=O14544	Suppressor of cytokine signaling 6	TAS	15032587	PubMed	PTHR44562:SF1	SUPPRESSOR OF CYTOKINE SIGNALING 6
P00049	Parkinson disease	P01238	14-3-3	HUMAN|HGNC=12854|UniProtKB=P27348	14-3-3 protein theta	IDA	10407019	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	DANRE|ZFIN=ZDB-GENE-051129-1|UniProtKB=Q4JLT0	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00054	Toll receptor signaling pathway	P01351	TLR2,4,7	RAT|RGD=1563357|UniProtKB=A5H2Z9	Protein Tlr7	ISS			PTHR44312:SF1	TOLL-LIKE RECEPTOR 7
P05731	GABA-B receptor II signaling	P05760	AC	BOVIN|Ensembl=ENSBTAG00000016629|UniProtKB=E1BM79	Adenylyl CYclase family member (Acy-1)-like	ISS	2491850	PubMed	PTHR11920:SF319	ADENYLATE CYCLASE TYPE 9
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00018	EGF receptor signaling pathway	P00555	MKK4,7	HUMAN|HGNC=6847|UniProtKB=O14733	Dual specificity mitogen-activated protein kinase kinase 7	ISS	15039780	PubMed	PTHR24361:SF387	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000003872|UniProtKB=E1BIQ3	Uncharacterized protein	ISS			PTHR19957:SF83	SYNTAXIN-16
P00006	Apoptosis signaling pathway	P00310	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	HUMAN|HGNC=705|UniProtKB=O15144	Actin-related protein 2/3 complex subunit 2	ISS	17943202	gi	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02775	Salvage pyrimidine ribonucleotides	P03150	Uridine kinase	MOUSE|MGI=MGI=1915806|UniProtKB=Q91YL3	Uridine-cytidine kinase-like 1	ISS			PTHR10285:SF68	URIDINE-CYTIDINE KINASE-LIKE 1
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	ARATH|TAIR=AT1G55970|UniProtKB=Q9LG11	Histone acetyltransferase HAC4	TAS	10823891	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00049	Parkinson disease	P01208	Hsp70	CAEEL|WormBase=WBGene00002005|UniProtKB=P09446	Heat shock 70 kDa protein A	IDA	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	USTMA|Gene=UMAG_11232|UniProtKB=A0A0D1DMT3	Chromosome 22, whole genome shotgun sequence	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00019	Endothelin signaling pathway	P00588	ET1-4	HUMAN|HGNC=3177|UniProtKB=P20800	Endothelin-2	ISS	12516960	PubMed	PTHR13874:SF9	ENDOTHELIN-2
P00006	Apoptosis signaling pathway	P00303	c-Jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	11840290	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00036	Interleukin signaling pathway	P00996	STAT	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	IC	12191995	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT4G01370|UniProtKB=Q39024	Mitogen-activated protein kinase 4	IDA	10851062	PubMed	PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P00019	Endothelin signaling pathway	P00572	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	YEAST|SGD=S000005738|UniProtKB=P18851	Guanine nucleotide-binding protein subunit beta	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00021	FGF signaling pathway	P00629	PP2A	ARATH|TAIR=AT1G50370|UniProtKB=Q9SX52	Phytochrome-associated serine/threonine-protein phosphatase 1	ISS			PTHR11668:SF24	SERINE/THREONINE-PROTEIN PHOSPHATASE 6 CATALYTIC SUBUNIT
P00010	B cell activation	P00375	Calmodulin	MONDO|Ensembl=ENSMODG00000023174|UniProtKB=F7D7P2	Uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF197	CALMODULIN-LIKE PROTEIN 3
P00053	T cell activation	P01297	MEKK	MACMU|Ensembl=ENSMMUG00000012387|UniProtKB=F7EB20	Uncharacterized protein	RCA	8643568	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=11334|UniProtKB=P35346	Somatostatin receptor type 5	IDA	12441358	PubMed	PTHR24229:SF20	SOMATOSTATIN RECEPTOR TYPE 5
P00018	EGF receptor signaling pathway	P00547	PP2A	MACMU|Ensembl=ENSMMUG00000004873|UniProtKB=F7ANY9	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00060	Ubiquitin proteasome pathway	P01490	E3	MACMU|Ensembl=ENSMMUG00000014193|UniProtKB=F7AKR9	Uncharacterized protein	ISS	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P05915	Opioid proenkephalin pathway	P05990	K+ channel	RAT|RGD=621451|UniProtKB=Q9ES08	Potassium channel subfamily K member 9	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P05918	p38 MAPK pathway	P06029	p38beta	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	BOVIN|Ensembl=ENSBTAG00000047202|UniProtKB=G3N3K3	Uncharacterized protein	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P02788	Xanthine and guanine salvage pathway	P03247	Xanthine phosphoribosyl transferase	BOVIN|Ensembl=ENSBTAG00000014685|UniProtKB=Q3SZ18	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF6	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE
P00021	FGF signaling pathway	P00643	Raf-1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	PANTR|Ensembl=ENSPTRG00000014711|UniProtKB=H2QZF5	TGF-beta receptor type-2	ISS	9759503	PubMed	PTHR23255:SF55	TGF-BETA RECEPTOR TYPE-2
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	MACMU|Ensembl=ENSMMUG00000023317|UniProtKB=F6Y514	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	RAT|RGD=70989|UniProtKB=Q78EA7	Bone morphogenetic protein receptor type-1A	TAS	10683140	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P00037	Ionotropic glutamate receptor pathway	P01005	NR2D	RAT|RGD=2740|UniProtKB=Q62645	Glutamate receptor ionotropic, NMDA 2D	ISS	11319238	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00057	Wnt signaling pathway	P01465	Ggamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00057	Wnt signaling pathway	P01444	Wnt	PANTR|Ensembl=ENSPTRG00000002062|UniProtKB=H2Q194	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P00034	Integrin signalling pathway	P00944	Actin	MONDO|Ensembl=ENSMODG00000023940|UniProtKB=F6RFW8	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00018	EGF receptor signaling pathway	P00545	JNK1-3	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IGI	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01205	NOS	HUMAN|HGNC=7876|UniProtKB=P29474	Nitric oxide synthase, endothelial	ISS	93055452	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00059	p53 pathway	P01480	PTEN	XENTR|Xenbase=XB-GENE-491433|UniProtKB=B1H2U0	Pten protein	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	RCA			PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00011	Blood coagulation	P00439	Prekallikrein	MACMU|Ensembl=ENSMMUG00000011633|UniProtKB=F6PJA8	Uncharacterized protein	ISS	4504877	gi	PTHR44459:SF2	PLASMA KALLIKREIN
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	ECOLI|EcoGene=EG10096|UniProtKB=P00509	Aspartate aminotransferase	ISS			PTHR11879:SF11	ASPARTATE AMINOTRANSFERASE
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	IPI	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PANTR|Ensembl=ENSPTRG00000009762|UniProtKB=H2QE24	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00020	FAS signaling pathway	P00610	MKK4	BOVIN|Ensembl=ENSBTAG00000012103|UniProtKB=A5PJP8	MAP2K4 protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	HUMAN|HGNC=236|UniProtKB=O95622	Adenylate cyclase type 5	ISS	1409703	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00036	Interleukin signaling pathway	P00990	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00168	E-cadherin intracellular fragment	MOUSE|MGI=MGI=88354|UniProtKB=P09803	Cadherin-1	IDA	12834808	PubMed	PTHR24027:SF319	CADHERIN-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	2837282	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00052	TGF-beta signaling pathway	G01548	I-SMAD	BOVIN|Ensembl=ENSBTAG00000000625|UniProtKB=E1BH37	Mothers against decapentaplegic homolog	ISS	9335505	PubMed	PTHR13703:SF28	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 6
P00057	Wnt signaling pathway	P01440	Cadherin	DROME|FlyBase=FBgn0001075|UniProtKB=P33450	Cadherin-related tumor suppressor	IDA	8120095	PubMed	PTHR24026:SF69	PROTOCADHERIN FAT 4
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	DEIRA|EnsemblGenome=DR_2374|UniProtKB=Q9RRW1	Ribonucleoside-diphosphate reductase	ISS			PTHR43371:SF1	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01206	14-3-3	CHICK|Ensembl=ENSGALG00000010725|UniProtKB=Q5ZKC9	14-3-3 protein zeta	ISS	12615066	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00056	VEGF signaling pathway	P01425	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00056	VEGF signaling pathway	P01417	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01152	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	227170	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P02777	Succinate to proprionate conversion	P03163	Methylmalonyl-CoA decarboxylase	CAEEL|WormBase=WBGene00018701|UniProtKB=Q20676	Propionyl Coenzyme A Carboxylase Beta subunit	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00011	Blood coagulation	P00458	GP IIIa	MOUSE|MGI=MGI=96612|UniProtKB=O54890	Integrin beta-3	ISS	280842	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00025	Hedgehog signaling pathway	P00683	Slimb	PANTR|Ensembl=ENSPTRG00000017526|UniProtKB=H2QS02	Uncharacterized protein	ISS	10074433	PubMed	PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P00018	EGF receptor signaling pathway	P00556	PLCgamma	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00056	VEGF signaling pathway	P01409	cPLA2	CANLF|Ensembl=ENSCAFG00000013778|UniProtKB=F6UQ33	Phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DROME|FlyBase=FBgn0003093|UniProtKB=P13678	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04552	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00005	Angiogenesis	P00238	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02913	Thymidylate synthase	PANTR|Ensembl=ENSPTRG00000009822|UniProtKB=G2HEY4	Fibronectin 1	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00034	Integrin signalling pathway	P00914	Filamin	MACMU|Ensembl=ENSMMUG00000000706|UniProtKB=F6YSU3	Uncharacterized protein	ISS	9722563	PubMed	PTHR43998:SF3	FILAMIN-B
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	ORYSJ|EnsemblGenome=OS07G0492000|UniProtKB=Q07661	Nucleoside diphosphate kinase 1	ISS			PTHR11349:SF66	SUBFAMILY NOT NAMED
P00023	General transcription regulation	P00658	TBP-associated factors	HUMAN|HGNC=11534|UniProtKB=Q15572	TATA box-binding protein-associated factor RNA polymerase I subunit C	ISS	20355009	PubMed	PTHR15319:SF1	TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT C
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	BOVIN|Ensembl=ENSBTAG00000002580|UniProtKB=F1MM57	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF462	MYOSIN-14
P00018	EGF receptor signaling pathway	P00541	Spry	MOUSE|MGI=MGI=1345144|UniProtKB=Q9WTP2	Protein sprouty homolog 4	ISS	22024232	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P00030	Hypoxia response via HIF activation	P00824	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00029	Huntington disease	P00786	ARF	TAKRU|Ensembl=ENSTRUG00000006254|UniProtKB=H2SS82	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	PANTR|Ensembl=ENSPTRG00000015856|UniProtKB=H2QP51	Regulator of G-protein signaling 12	ISS	8756726	PubMed	PTHR10845:SF149	REGULATOR OF G-PROTEIN SIGNALING 12
P00021	FGF signaling pathway	P00629	PP2A	XENTR|Xenbase=XB-GENE-484003|UniProtKB=Q6P365	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ORYSJ|EnsemblGenome=OS06G0173100|UniProtKB=Q5SNC0	Os06g0173100 protein	ISS			PTHR23073:SF7	26S PROTEASE REGULATORY SUBUNIT 6A
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	14744463	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00012	Cadherin signaling pathway	P00471	Cadherin	DROME|FlyBase=FBgn0015609|UniProtKB=O15943	Neural-cadherin	IDA	8120095	PubMed	PTHR43956:SF4	NEURAL-CADHERIN
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	PRIPA|Gene=PPA22610|UniProtKB=H3FK05	Uncharacterized protein	ISS			PTHR24072:SF192	CDC42 HOMOLOG
P06587	Nicotine pharmacodynamics pathway	P06595	CHRNA3	HUMAN|HGNC=1957|UniProtKB=P32297	Neuronal acetylcholine receptor subunit alpha-3	IDA	12098588	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	IC	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P06664	Gonadotropin-releasing hormone receptor pathway	P06777	NFAT	MOUSE|MGI=MGI=103296|UniProtKB=P97305	Nuclear factor of activated T-cells, cytoplasmic 3	RCA	9133421	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00047	PDGF signaling pathway	P01162	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00402	Jnk	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00023	General transcription regulation	P00660	RNA Polymerase II	DAPPU|EnsemblGenome=DAPPUDRAFT_308488|UniProtKB=E9G252	Putative uncharacterized protein	ISS	11313498	gi	PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00034	Integrin signalling pathway	P00906	Rap1	BOVIN|Ensembl=ENSBTAG00000008967|UniProtKB=P61223	Ras-related protein Rap-1b	ISS	10476970	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	IC	1482697	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00019	Endothelin signaling pathway	P00578	eNOS	CANLF|Gene=NOS3|UniProtKB=Q9TUX8	Nitric oxide synthase, endothelial	ISS	22462730	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	DICDI|dictyBase=DDB_G0277143|UniProtKB=P36408	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00035	Interferon-gamma signaling pathway	P00956	SOCS	BOVIN|Gene=SOCS5|UniProtKB=Q29RN6	Suppressor of cytokine signaling 5	ISS	22247722	PubMed	PTHR44282:SF3	SUPPRESSOR OF CYTOKINE SIGNALING 5
P04398	p53 pathway feedback loops 2	P04665	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00056	VEGF signaling pathway	P01408	Akt/PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00564	Rac	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00004	Alzheimer disease-presenilin pathway	P00114	actin	XENTR|Xenbase=XB-GENE-490883|UniProtKB=Q6NVA9	Actin, cytoplasmic 1	ISS	11889139	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	STRPU|Gene=CYIIIA|UniProtKB=P53474	Actin, cytoskeletal 3A	IC	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	BOVIN|Ensembl=ENSBTAG00000009277|UniProtKB=A7MBG6	RGS17 protein	ISS	8756726	PubMed	PTHR10845:SF196	REGULATOR OF G-PROTEIN SIGNALING 17
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	RAT|RGD=67385|UniProtKB=Q8VGC3	Voltage-dependent L-type calcium channel subunit beta-2	IC	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01093	AChE	BOVIN|Gene=ACHE|UniProtKB=P23795	Acetylcholinesterase	IC			PTHR43142:SF1	CARBOXYLIC ESTER HYDROLASE
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00017	DNA replication	P00534	PCNA	METJA|EnsemblGenome=MJ_0247|UniProtKB=Q57697	DNA polymerase sliding clamp	ISS	96337999	PubMed	PTHR11352:SF0	PROLIFERATING CELL NUCLEAR ANTIGEN
P05916	Opioid prodynorphin pathway	P06002	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00049	Parkinson disease	P01219	SAPK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04586	ProTRH (Pro Thyrotropin-releasing Hormone)	RAT|RGD=3910|UniProtKB=P04652	Thyrotropin subunit beta	ISS			PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	RAT|RGD=2869|UniProtKB=P24062	Insulin-like growth factor 1 receptor	ISS	11182407	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00053	T cell activation	P01332	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02741	Flavin biosynthesis	P02934	Riboflavin kinase	XENTR|Xenbase=XB-GENE-1010122|UniProtKB=Q28GD6	Riboflavin kinase	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	IC	10514528	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00545	JNK1-3	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00391	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01457	GBeta	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04393	Ras Pathway	P04558	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	PANTR|Ensembl=ENSPTRG00000002339|UniProtKB=H2R368	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00024	Glycolysis	P00675	Pyruvate kinase	ARATH|TAIR=AT1G32440|UniProtKB=Q93Z53	Plastidial pyruvate kinase 3, chloroplastic	TAS	18398434	gi	PTHR11817:SF26	PLASTIDIAL PYRUVATE KINASE 3, CHLOROPLASTIC
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00564	Rac	CHICK|Ensembl=ENSGALG00000002859|UniProtKB=F6UBD2	Uncharacterized protein	ISS	15470041	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00059	p53 pathway	P01486	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DICDI|dictyBase=DDB_G0268622|UniProtKB=P34145	Rho-related protein rac1B	ISS	4757952	gi	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	SCHPO|PomBase=SPAC23C11.11|UniProtKB=P40231	Casein kinase II subunit alpha	IDA	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00029	Huntington disease	P00769	N-Wasp	CHICK|Ensembl=ENSGALG00000008797|UniProtKB=E1BTH9	Uncharacterized protein	ISS	12932731	PubMed	PTHR23202:SF39	NEURAL WISKOTT-ALDRICH SYNDROME PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00053	T cell activation	P01324	rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	15470041	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CHICK|Ensembl=ENSGALG00000008512|UniProtKB=F1P0S6	Uncharacterized protein	ISS	20112749	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00057	Wnt signaling pathway	P01451	Galpha	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	IDA	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MACMU|Ensembl=ENSMMUG00000020809|UniProtKB=F7H7P8	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P00057	Wnt signaling pathway	P01438	PP2A	MACMU|Ensembl=ENSMMUG00000019771|UniProtKB=F7APV7	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform 1	ISS	10092233	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00563	Gab	XENTR|Xenbase=XB-GENE-1008133|UniProtKB=F6YPY3	Uncharacterized protein (Fragment)	ISS			PTHR12156:SF18	GRB2-ASSOCIATED-BINDING PROTEIN 1
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00029	Huntington disease	P00775	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12676940	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P05916	Opioid prodynorphin pathway	P06000	vasopressin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IGI	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04572	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05730	Endogenous cannabinoid signaling	P05748	mGluR	CHICK|Ensembl=ENSGALG00000017238|UniProtKB=F1NWG3	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P05912	Dopamine receptor mediated signaling pathway	P05949	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8479536	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=16267|UniProtKB=Q9UBV4	Protein Wnt-16	TAS	11266476	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P04397	p53 pathway by glucose deprivation	P04641	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	BOVIN|Gene=CACNB1|UniProtKB=Q9MZL7	Voltage-dependent L-type calcium channel subunit beta-1	ISS	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	ANOGA|EnsemblGenome=AGAP011481|UniProtKB=Q7PMY1	AGAP011481-PA (Fragment)	ISS	12181435	PubMed	PTHR24247:SF117	5-HYDROXYTRYPTAMINE RECEPTOR 2A-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01452	NFAT	RAT|RGD=1310749|UniProtKB=D3Z9H7	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	ISS	12015605	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	CANLF|Ensembl=ENSCAFG00000003995|UniProtKB=E2RC09	Tyrosine-protein kinase	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00017	DNA replication	P00533	Pol delta	METAC|EnsemblGenome=MA_0885|UniProtKB=Q8TSB3	DNA polymerase	ISS	21929760	PubMed	PTHR10322:SF21	DNA POLYMERASE ALPHA CATALYTIC SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00053	T cell activation	P01322	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	MOUSE|MGI=MGI=2679420|UniProtKB=Q3ULB5	Serine/threonine-protein kinase PAK 6	ISS			PTHR24361:SF182	SERINE/THREONINE-PROTEIN KINASE PAK 6
P05912	Dopamine receptor mediated signaling pathway	P05963	MAO	MOUSE|MGI=MGI=96916|UniProtKB=Q8BW75	Amine oxidase [flavin-containing] B	ISS	8602220	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P00054	Toll receptor signaling pathway	P01369	MKK1	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=2155600|UniProtKB=Q91Z83	Myosin-7	IC	89264452	PubMed	PTHR13140:SF344	MYOSIN-7
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	DANRE|ZFIN=ZDB-GENE-010607-2|UniProtKB=Q90VV9	Insulin-like growth factor 1	ISS			PTHR11454:SF4	INSULIN-LIKE GROWTH FACTOR I
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00717	Phosphorylase b	PANTR|Ensembl=ENSPTRG00000003845|UniProtKB=H2Q405	Alpha-1,4 glucan phosphorylase	ISS	4318782	PubMed	PTHR11468:SF13	GLYCOGEN PHOSPHORYLASE, MUSCLE FORM
P05918	p38 MAPK pathway	P06034	MKK4	PANTR|Ensembl=ENSPTRG00000008783|UniProtKB=H2QCA7	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00021	FGF signaling pathway	P00629	PP2A	DANRE|ZFIN=ZDB-GENE-040426-2086|UniProtKB=Q6NY64	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform	ISS	12110603	PubMed	PTHR11871:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B DELTA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	ISS	10704417	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00048	PI3 kinase pathway	P01185	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00021	FGF signaling pathway	P00633	Ras	MONDO|Gene=KRAS|UniProtKB=Q07983	GTPase KRas	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02753	Methionine biosynthesis	P03024	Homocysteine transmethylase	SYNY3|EnsemblGenome=BAA10438|UniProtKB=Q55786	Methionine synthase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	DROME|FlyBase=FBgn0040510|UniProtKB=Q9VK51	ACXA, isoform A	IGI			PTHR11920:SF338	ACXA, ISOFORM A-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=108061|UniProtKB=P48614	Protein Wnt-10b	IDA	11266476	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	PANTR|Ensembl=ENSPTRG00000007461|UniProtKB=H2QA34	Furin (Paired basic amino acid cleaving enzyme)	ISS	95328031	PubMed	PTHR42884:SF1	FURIN
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00060	Ubiquitin proteasome pathway	P01490	E3	CANLF|Ensembl=ENSCAFG00000020247|UniProtKB=E2RBA6	E3 ubiquitin-protein ligase	ISS			PTHR11254:SF396	NEDD4-LIKE E3 UBIQUITIN-PROTEIN LIGASE WWP2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00034	Integrin signalling pathway	P00944	Actin	MONDO|Ensembl=ENSMODG00000025373|UniProtKB=F6ZZG9	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	IGI	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02743	Formyltetrahydroformate biosynthesis	P02952	Methylene tetrahydrofolate dehydrogenase	THEMA|EnsemblGenome=TM_1767|UniProtKB=Q9X288	Bifunctional protein FolD	ISS			PTHR10025:SF46	BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, MITOCHONDRIAL
P00005	Angiogenesis	P00221	JNK1	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00054	Toll receptor signaling pathway	P01352	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P06664	Gonadotropin-releasing hormone receptor pathway	P06812	L-type Ca2+	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	RCA	15737619	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ARATH|TAIR=AT3G18780|UniProtKB=Q96292	Actin-2	IC	10974003	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000022513|UniProtKB=F6YNZ0	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	AQUAE|EnsemblGenome=aq_1221|UniProtKB=O67271	Glutamate--tRNA ligase	ISS			PTHR43311:SF2	GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED
P00007	Axon guidance mediated by semaphorins	P00340	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00052	TGF-beta signaling pathway	P01288	FKBP12	CAEEL|WormBase=WBGene00001433|UniProtKB=Q8I4E5	Peptidyl-prolyl cis-trans isomerase	ISS			PTHR10516:SF341	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00020	FAS signaling pathway	P00600	PARP	CHICK|Gene=PARP1|UniProtKB=P26446	Poly [ADP-ribose] polymerase 1	TAS	12101391	PubMed	PTHR10459:SF80	POLY  ADP-RIBOSE  POLYMERASE 1
P04395	Vasopressin synthesis	P04593	Glycopeptide	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	IC	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00047	PDGF signaling pathway	P01149	MNK1/2	RAT|RGD=1559603|UniProtKB=Q4G050	MAP kinase-interacting serine/threonine-protein kinase 1	ISS	9155017	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00976	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IPI	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	P00558	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00057	Wnt signaling pathway	P01455	Smad4	HUMAN|HGNC=6767|UniProtKB=Q15797	Mothers against decapentaplegic homolog 1	IDA	9395284	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MACMU|Ensembl=ENSMMUG00000006492|UniProtKB=F7H998	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	MOUSE|MGI=MGI=1202876|UniProtKB=Q9Z1J1	Transcription factor 7-like 1	TAS	11266476	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00010	B cell activation	P00383	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	CANLF|Ensembl=ENSCAFG00000012934|UniProtKB=F1P750	Uncharacterized protein	ISS	8649450	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P02742	Tetrahydrofolate biosynthesis	P02946	5-Hydroxymethyl-7,8-dihydropteridine pyrophosphokinase	RHOBA|EnsemblGenome=RB1874|UniProtKB=Q7UWQ3	Probable 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	ISS			PTHR43071:SF1	2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE
P04398	p53 pathway feedback loops 2	G04709	MDM-2	RAT|RGD=1309306|UniProtKB=Q5XIN1	Protein Mdm4	ISS			PTHR13844:SF20	PROTEIN MDM4
P00018	EGF receptor signaling pathway	G01511	SPRY	CANLF|Ensembl=ENSCAFG00000005260|UniProtKB=E2RGU9	Uncharacterized protein	ISS	12815057	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P02738	De novo purine biosynthesis	P02905	Amidophosphoribosyl transferase	MACMU|Ensembl=ENSMMUG00000016362|UniProtKB=F7GPV9	Amidophosphoribosyltransferase	ISS			PTHR11907:SF18	AMIDOPHOSPHORIBOSYLTRANSFERASE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	ARATH|TAIR=AT1G08700|UniProtKB=O64668	Presenilin-like protein At1g08700	TAS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01182	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00034	Integrin signalling pathway	P00927	Rac	DICPU|Gene=DICPUDRAFT_55703|UniProtKB=F0ZN94	Putative uncharacterized protein racC	ISS	8649368	PubMed	PTHR24072:SF117	RHO-RELATED PROTEIN RACC
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02728	Arginine biosynthesis	P02847	N-actetylornithine deacetylase	BACTN|EnsemblGenome=BT_2085|UniProtKB=Q8A601	Putative succinyl-diaminopimelate desuccinylase	ISS			PTHR43270:SF4	RE11562P
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	ENTHI|EnsemblGenome=EHI_181250|UniProtKB=C4M5Z7	Rho family GTPase	ISS	8649368	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00018	EGF receptor signaling pathway	P00539	14-3-3	CHICK|Ensembl=ENSGALG00000004143|UniProtKB=Q5ZLQ6	14-3-3 protein beta/alpha	ISS	10407019	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00019	Endothelin signaling pathway	P00577	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04395	Vasopressin synthesis	P04594	Neurophysin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00049	Parkinson disease	P01213	Cyclin E	MACMU|Ensembl=ENSMMUG00000020668|UniProtKB=F7BEI4	Uncharacterized protein	ISS	12628165	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00029	Huntington disease	P00788	Calpain	MOUSE|MGI=MGI=1344392|UniProtKB=Q9ESK3	Calpain-10	IDA	11675509	PubMed	PTHR10183:SF30	CALPAIN-10
P00018	EGF receptor signaling pathway	P00551	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00054	Toll receptor signaling pathway	P01369	MKK1	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	G01532	PolyQ HTT	MACMU|Ensembl=ENSMMUG00000008392|UniProtKB=F6VQZ3	Uncharacterized protein	ISS	8268927	PubMed	PTHR10170:SF10	HUNTINGTIN
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04393	Ras Pathway	P04558	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	IDA	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00540	MKK3,6	CANLF|Ensembl=ENSCAFG00000018530|UniProtKB=F1PXD3	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00049	Parkinson disease	P01235	Fyn kinase	RAT|RGD=2641|UniProtKB=Q62844	Tyrosine-protein kinase Fyn	IDA	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P02731	Biotin biosynthesis	P02857	Biotin synthase	FUSNN|EnsemblGenome=FN1000|UniProtKB=Q8REU0	Biotin synthase	ISS			PTHR22976:SF1	BIOTIN SYNTHASE, MITOCHONDRIAL
P00005	Angiogenesis	P00194	Paxillin	MOUSE|MGI=MGI=102784|UniProtKB=Q62219	Transforming growth factor beta-1-induced transcript 1 protein	ISS			PTHR24216:SF27	TRANSFORMING GROWTH FACTOR BETA-1-INDUCED TRANSCRIPT 1 PROTEIN
P00029	Huntington disease	P00779	TBP	CANLF|Ensembl=ENSCAFG00000004119|UniProtKB=F1PQA5	Uncharacterized protein	ISS	600075	OMIM	PTHR10126:SF20	TATA-BOX-BINDING PROTEIN
P00010	B cell activation	P00386	Calcineurin	HUMAN|HGNC=9314|UniProtKB=Q08209	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	IDA	12091710	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IDA	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00036	Interleukin signaling pathway	P00990	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	RAT|RGD=62045|UniProtKB=Q99PS2	Casein kinase1 epsilon-2	ISS	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P05726	2-arachidonoylglycerol biosynthesis	P05736	DGL	CHICK|Ensembl=ENSGALG00000015425|UniProtKB=P11602	Lipoprotein lipase	RCA			PTHR11610:SF3	LIPOPROTEIN LIPASE
P02721	ATP synthesis	P02799	Cyt bc1	RAT|RGD=1306597|UniProtKB=D3ZFQ8	Cytochrome c-1 (Predicted), isoform CRA_c	ISS	12477932	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00005	Angiogenesis	P00237	FRP	CANLF|Ensembl=ENSCAFG00000008293|UniProtKB=E2R9M9	Uncharacterized protein	ISS	12549854	PubMed	PTHR11309:SF22	FRIZZLED-3
P00010	B cell activation	P00402	Jnk	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04546	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	HUMAN|HGNC=1736|UniProtKB=P60953	Cell division control protein 42 homolog	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	DROME|FlyBase=FBgn0086347|UniProtKB=Q23978	Myosin-IA	IC			PTHR13140:SF713	MYOSIN-IA
P00004	Alzheimer disease-presenilin pathway	P00111	C99	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	CAEEL|WormBase=WBGene00001679|UniProtKB=P17343	Guanine nucleotide-binding protein subunit beta-1	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01238	14-3-3	ARATH|TAIR=AT5G10450|UniProtKB=P48349	14-3-3-like protein GF14 lambda	IDA	10407019	PubMed	PTHR18860:SF27	14-3-3-LIKE PROTEIN GF14 LAMBDA
P00018	EGF receptor signaling pathway	P00556	PLCgamma	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02748	Isoleucine biosynthesis	P02998	Dihydroxyacid dehydratase	ECOLI|EcoGene=EG13345|UniProtKB=P77596	Uncharacterized protein YagF	ISS			PTHR43661:SF2	SUBFAMILY NOT NAMED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CHICK|Ensembl=ENSGALG00000013818|UniProtKB=Q9DDW4	Cited2/melanocyte specific gene-related gene 1 MRG1	TAS	9865691	PubMed	PTHR17045:SF7	CBP/P300-INTERACTING TRANSACTIVATOR 2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00020	FAS signaling pathway	P00607	Pro-Caspase6	XENTR|Xenbase=XB-GENE-482797|UniProtKB=F6R1R1	Uncharacterized protein	ISS	11463840	PubMed	PTHR10454:SF164	CASPASE-6
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	MACMU|Ensembl=ENSMMUG00000003857|UniProtKB=F7HA84	Nucleoside diphosphate kinase	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P04398	p53 pathway feedback loops 2	P04665	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000023940|UniProtKB=F6RFW8	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	PANTR|Ensembl=ENSPTRG00000008769|UniProtKB=H2R9J3	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF681	MYOSIN-4
P02750	Lipoate_biosynthesis	P03004	Lipoate synthase	PANTR|Ensembl=ENSPTRG00000015994|UniProtKB=H2QPC8	Lipoyl synthase, mitochondrial	ISS			PTHR10949:SF0	LIPOYL SYNTHASE, MITOCHONDRIAL
P00012	Cadherin signaling pathway	P00474	Wnt	BRAFL|Gene=BRAFLDRAFT_271417|UniProtKB=C3ZCG7	Protein Wnt	IDA	11266476	PubMed	PTHR12027:SF102	PROTEIN WNT-4
P00019	Endothelin signaling pathway	P00567	PKG	PLAF7|EnsemblGenome=PF14_0346|UniProtKB=Q8I719	cGMP-dependent protein kinase	IGI	21975164	PubMed	PTHR24353:SF112	SUBFAMILY NOT NAMED
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00053	T cell activation	P01311	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01182	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00034	Integrin signalling pathway	P00916	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IPI	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00048	PI3 kinase pathway	P01192	p110	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00050	Plasminogen activating cascade	P01254	pro-MMP-13	MACMU|Ensembl=ENSMMUG00000004253|UniProtKB=F6YQ28	Uncharacterized protein	ISS	8207000	PubMed	PTHR10201:SF165	COLLAGENASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=1310903|UniProtKB=D4A978	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF33	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-3
P00036	Interleukin signaling pathway	P00996	STAT	MOUSE|MGI=MGI=103062|UniProtKB=P42228	Signal transducer and activator of transcription 4	IC	94255416	PubMed	PTHR11801:SF19	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 4
P00054	Toll receptor signaling pathway	P01352	p38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00059	p53 pathway	G04689	Cyclin G	BOVIN|Ensembl=ENSBTAG00000006607|UniProtKB=Q5E9I1	Cyclin-G1	ISS	15077171	PubMed	PTHR10177:SF59	CYCLIN-G1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IDA			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00029	Huntington disease	P00790	beta-Tubulin	CHICK|Ensembl=ENSGALG00000007447|UniProtKB=P09207	Tubulin beta-6 chain	TAS	12932731	PubMed	PTHR11588:SF112	TUBULIN BETA-1 CHAIN
P00029	Huntington disease	P00807	Actin	MACMU|Ensembl=ENSMMUG00000012054|UniProtKB=F6TII3	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MACMU|Ensembl=ENSMMUG00000004886|UniProtKB=F7AGT9	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02782	Triacylglycerol metabolism	P03205	Triacylglycerol lipase	RAT|RGD=3009|UniProtKB=P07867	Hepatic triacylglycerol lipase	RCA			PTHR11610:SF2	HEPATIC TRIACYLGLYCEROL LIPASE
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	ORNAN|Ensembl=ENSOANG00000003489|UniProtKB=F7FSE3	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P02750	Lipoate_biosynthesis	P03004	Lipoate synthase	CHLTR|EnsemblGenome=CT_558|UniProtKB=O84562	Lipoyl synthase	ISS			PTHR10949:SF24	LIPOYL SYNTHASE
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00223	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02738	De novo purine biosynthesis	P02900	AICAR transformylase	ANOGA|EnsemblGenome=AGAP001423|UniProtKB=Q7PXI8	AGAP001423-PA	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CHICK|Ensembl=ENSGALG00000001334|UniProtKB=F1NLV4	Uncharacterized protein	IC	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05918	p38 MAPK pathway	P06031	p38alpha	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	RCA	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00225	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	RCA			PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P02771	Pyrimidine Metabolism	P03124	Methylmalonate Semialdehyde Dehydrogenase	MOUSE|MGI=MGI=1915077|UniProtKB=Q9EQ20	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	IPI	1527093	PubMed	PTHR43866:SF3	METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE  ACYLATING , MITOCHONDRIAL
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CHICK|Ensembl=ENSGALG00000015835|UniProtKB=F1NZT2	Uncharacterized protein	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00019	Endothelin signaling pathway	P00587	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00969	Signaling subunit	HUMAN|HGNC=6021|UniProtKB=P40189	Interleukin-6 receptor subunit beta	TAS	10210178	PubMed	PTHR23036:SF83	INTERLEUKIN-6 RECEPTOR SUBUNIT BETA
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IDA	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00645	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00057	Wnt signaling pathway	P01429	Axin	DANRE|ZFIN=ZDB-GENE-000403-2|UniProtKB=P57095	Axin-2	IDA	9554852	PubMed	PTHR10845:SF103	AXIN-2
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	MONDO|Ensembl=ENSMODG00000018237|UniProtKB=F6PG65	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00021	FGF signaling pathway	P00627	ERK1-2	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00012	Cadherin signaling pathway	P00464	Fyn	MACMU|Ensembl=ENSMMUG00000014635|UniProtKB=F7G2C9	Tyrosine-protein kinase	ISS			PTHR24418:SF296	TYROSINE-PROTEIN KINASE FRK
P00012	Cadherin signaling pathway	P00474	Wnt	BOVIN|Ensembl=ENSBTAG00000005570|UniProtKB=E1BKL2	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P00029	Huntington disease	P00807	Actin	DROME|FlyBase=FBgn0000046|UniProtKB=P10981	Actin-87E	IDA	11889126	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00012	Cadherin signaling pathway	P00464	Fyn	DANRE|ZFIN=ZDB-GENE-030903-5|UniProtKB=Q6EWH2	Tyrosine-protein kinase fyna	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00018	EGF receptor signaling pathway	P00551	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	CHICK|Ensembl=ENSGALG00000004083|UniProtKB=Q90855	AMPA receptor GluR1/A	ISS	12871085	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00005	Angiogenesis	P00223	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04398	p53 pathway feedback loops 2	P04657	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00203	Erk	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01162	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00059	p53 pathway	G04694	p110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00011	Blood coagulation	P00436	GP 1bbeta	PANTR|Ensembl=ENSPTRG00000033843|UniProtKB=H2RCB6	Glycoprotein Ib (Platelet), beta polypeptide	ISS	97403789	PubMed	PTHR22650:SF7	PLATELET GLYCOPROTEIN IB BETA CHAIN
P04393	Ras Pathway	P04570	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	RCA	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00034	Integrin signalling pathway	P00923	Arf1	HUMAN|HGNC=692|UniProtKB=P40616	ADP-ribosylation factor-like protein 1	IPI	11752622	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P00030	Hypoxia response via HIF activation	P00824	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	TAS	3755548	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	HUMAN|HGNC=4586|UniProtKB=Q13224	Glutamate receptor ionotropic, NMDA 2B	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01154	Ras	XENTR|Xenbase=XB-GENE-5963250|UniProtKB=F6Z499	Uncharacterized protein (Fragment)	ISS			PTHR24073:SF335	RAS-RELATED PROTEIN RAB-11B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	ORNAN|Ensembl=ENSOANG00000000999|UniProtKB=F6WN02	Actin-related protein 2/3 complex subunit 5	ISS	12473693	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00004	Alzheimer disease-presenilin pathway	P00165	E-cadherin N-terminal fragment	MOUSE|MGI=MGI=88356|UniProtKB=P10287	Cadherin-3	TAS	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01390	TFIIA complex	PANTR|Ensembl=ENSPTRG00000039894|UniProtKB=H2RAZ7	Uncharacterized protein	ISS			PTHR12694:SF9	PROTEIN STON1-GTF2A1L-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	IC	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P02768	Proline biosynthesis	P03112	Glutamate semialdehyde dehydrogenase	SYNY3|EnsemblGenome=BAA10399|UniProtKB=P54902	Gamma-glutamyl phosphate reductase 1	ISS			PTHR11063:SF8	DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE
P00007	Axon guidance mediated by semaphorins	P00340	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00048	PI3 kinase pathway	P01182	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	TAS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00029	Huntington disease	P00796	Kainate receptor	MONDO|Ensembl=ENSMODG00000020977|UniProtKB=F6S5B1	Uncharacterized protein (Fragment)	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00047	PDGF signaling pathway	P01173	STAT	MACMU|Ensembl=ENSMMUG00000010705|UniProtKB=F7G8V4	Signal transducer and activator of transcription	ISS	8584036	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	BOVIN|Ensembl=ENSBTAG00000018114|UniProtKB=Q28043	Activin receptor type-2A	TAS	9395284	PubMed	PTHR23255:SF64	ACTIVIN RECEPTOR TYPE-2A
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00046	Oxidative stress response	P01131	MKP5	DANRE|ZFIN=ZDB-GENE-030613-1|UniProtKB=Q7T2L8	Dual specificity protein phosphatase	ISS			PTHR10159:SF45	DUAL SPECIFICITY PROTEIN PHOSPHATASE 6
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	9094314	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05731	GABA-B receptor II signaling	P05754	Ggamma	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	TAS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00634	MEKK1-5	BOVIN|Ensembl=ENSBTAG00000009065|UniProtKB=F1MXH6	Uncharacterized protein	ISS	12968034	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P02721	ATP synthesis	P02791	F1 alpha	TAKRU|Ensembl=ENSTRUG00000018034|UniProtKB=H2VAE8	ATP synthase subunit alpha	ISS	2527557	PubMed	PTHR43089:SF5	ATP SYNTHASE SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00589	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00623	FGF	BOVIN|Ensembl=ENSBTAG00000005198|UniProtKB=P03968	Fibroblast growth factor 1	IGI	87016918	PubMed	PTHR11486:SF86	FIBROBLAST GROWTH FACTOR 1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	ORNAN|Ensembl=ENSOANG00000013961|UniProtKB=F6VPY1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00021	FGF signaling pathway	P00647	SHP2	BOVIN|Ensembl=ENSBTAG00000002048|UniProtKB=F1N339	Tyrosine-protein phosphatase non-receptor type	ISS	7681589	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	BOVIN|Ensembl=ENSBTAG00000001575|UniProtKB=F1N6C0	Uncharacterized protein	ISS			PTHR23050:SF311	CALMODULIN
P00012	Cadherin signaling pathway	P00470	F-actin	HUMAN|HGNC=132|UniProtKB=P60709	Actin, cytoplasmic 1	IC	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00012	Cadherin signaling pathway	P00470	F-actin	DICDI|dictyBase=DDB_G0269234|UniProtKB=P07830	Major actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00015	Circadian clock system	G01503	per	HUMAN|HGNC=8846|UniProtKB=O15055	Period circadian protein homolog 2	IDA	11232563	PubMed	PTHR11269:SF9	PERIOD CIRCADIAN PROTEIN HOMOLOG 2
P00056	VEGF signaling pathway	P01414	PLC-gamma	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00018	EGF receptor signaling pathway	P00565	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IGI	3755548	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	NEMVE|Gene=v1g88970|UniProtKB=A7RPN8	Predicted protein (Fragment)	ISS	7514101	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00021	FGF signaling pathway	P00642	MEK1-2	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00020	FAS signaling pathway	P00610	MKK4	DROME|FlyBase=FBgn0024326|UniProtKB=O61444	MAP kinase kinase 4, isoform A	TAS	7600581	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	ANOGA|EnsemblGenome=AGAP004476|UniProtKB=Q7QA16	AGAP004476-PA	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	HUMAN|HGNC=8590|UniProtKB=Q13153	Serine/threonine-protein kinase PAK 1	ISS	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	HUMAN|HGNC=1953|UniProtKB=P08173	Muscarinic acetylcholine receptor M4	TAS	8100450	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PUCGT|EnsemblGenome=PGTG_05488|UniProtKB=E3K4I1	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00020	FAS signaling pathway	P00615	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	RAT|RGD=3425|UniProtKB=P97887	Presenilin-1	TAS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00053	T cell activation	P01311	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05918	p38 MAPK pathway	P06032	MKK6	MACMU|Ensembl=ENSMMUG00000001051|UniProtKB=F6QNB5	Dual specificity mitogen-activated protein kinase kinase 6	ISS	8622669	PubMed	PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	10540223	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00057	Wnt signaling pathway	P01443	Phospholipase C	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IC	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00036	Interleukin signaling pathway	P00996	STAT	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	IC	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	ANOGA|EnsemblGenome=AGAP000708|UniProtKB=F5HJW0	AGAP000708-PB	IDA	10487978	PubMed	PTHR10749:SF7	PHOSPHORYLASE B KINASE REGULATORY SUBUNIT ALPHA-RELATED
P00021	FGF signaling pathway	P00636	FGFR1-4	PANTR|Ensembl=ENSPTRG00000020176|UniProtKB=H2R210	Fibroblast growth factor receptor	ISS	2544996	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06768	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	RCA	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00034	Integrin signalling pathway	P00925	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IDA	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00012	Cadherin signaling pathway	P00470	F-actin	XENTR|Xenbase=XB-GENE-480347|UniProtKB=Q6P640	Actin, alpha cardiac muscle 1	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	RCA	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	RAT|RGD=620027|UniProtKB=P08911	Muscarinic acetylcholine receptor M5	TAS	10069496	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00036	Interleukin signaling pathway	P00982	p27KIP1	HUMAN|HGNC=1785|UniProtKB=P46527	Cyclin-dependent kinase inhibitor 1B	ISS			PTHR10265:SF9	CYCLIN-DEPENDENT KINASE INHIBITOR 1B
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	HUMAN|HGNC=9509|UniProtKB=P49810	Presenilin-2	TAS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P02723	Adenine and hypoxanthine salvage pathway	P02804	Hypoxanthine phosphoribosyl transferase	FUSNN|EnsemblGenome=FN0288|UniProtKB=Q8RGK5	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00053	T cell activation	P01307	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=103077|UniProtKB=Q64704	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00017	DNA replication	P00527	Histones	RAT|RGD=1306445|UniProtKB=D3ZJ08	Histone H3	ISS	12413958	PubMed	PTHR11426:SF161	HISTONE H3.2-RELATED
P00045	Notch signaling pathway	P01119	NIct	MACMU|Ensembl=ENSMMUG00000018375|UniProtKB=F7H1D5	Neurogenic locus notch homolog protein 2 isoform 1 preproprotein	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02775	Salvage pyrimidine ribonucleotides	P03156	CDP kinase	ARATH|TAIR=AT3G27190|UniProtKB=Q9LK34	Uridine kinase-like protein 2, chloroplastic	ISS			PTHR10285:SF70	URIDINE-CYTIDINE KINASE 2
P00057	Wnt signaling pathway	P01452	NFAT	HUMAN|HGNC=7777|UniProtKB=Q12968	Nuclear factor of activated T-cells, cytoplasmic 3	IDA	9462517	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	RAT|RGD=69069|UniProtKB=P50231	C-C motif chemokine 5	ISS	250208	gi	PTHR12015:SF82	C-C MOTIF CHEMOKINE 5
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00780	Microtubule	CAEBR|Gene=CBG18319|UniProtKB=A8XSF1	Protein CBR-TBB-1	ISS	9454836	PubMed	PTHR11588:SF157	TUBULIN, BETA
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	BOVIN|Ensembl=ENSBTAG00000011723|UniProtKB=E1BKL6	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04393	Ras Pathway	P04542	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	93028473	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00006	Apoptosis signaling pathway	P00310	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00036	Interleukin signaling pathway	P00967	c-fos	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	TAS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_94959|UniProtKB=C3XYC4	Putative uncharacterized protein	IDA	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00005	Angiogenesis	P00226	Delta/Serrate	XENTR|Xenbase=XB-GENE-479210|UniProtKB=A4IHM4	Delta-like protein	ISS			PTHR24044:SF380	DELTA-LIKE PROTEIN 1
P00053	T cell activation	P01316	MHC-antigen	MOUSE|MGI=MGI=96534|UniProtKB=P04441	H-2 class II histocompatibility antigen gamma chain	IPI	73139	PubMed	PTHR14093:SF17	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN GAMMA CHAIN
P00060	Ubiquitin proteasome pathway	P01492	E1	YEAST|SGD=S000001693|UniProtKB=P22515	Ubiquitin-activating enzyme E1 1	ISS			PTHR10953:SF4	GH24511P
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	IC	14744463	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P04375	5HT3 type receptor mediated signaling pathway	P04425	K+ channel	HUMAN|HGNC=6283|UniProtKB=Q9NPC2	Potassium channel subfamily K member 9	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00056	VEGF signaling pathway	P01411	Ras	DICDI|dictyBase=DDB_G0283537|UniProtKB=P32254	Ras-like protein rasS	ISS	8290260	PubMed	PTHR24070:SF380	RAS-LIKE PROTEIN RASS
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	RAT|RGD=1309458|UniProtKB=D3ZTP0	10-formyltetrahydrofolate dehydrogenase	ISS			PTHR11699:SF131	MITOCHONDRIAL 10-FORMYLTETRAHYDROFOLATE DEHYDROGENASE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00018	EGF receptor signaling pathway	P00556	PLCgamma	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00009	Axon guidance mediated by netrin	P00363	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	ISS	10799299	PubMed	PTHR10048:SF14	PI-3 KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Gene=GRIK4|UniProtKB=Q5IS46	Glutamate receptor ionotropic, kainate 4	ISS	12778120	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00056	VEGF signaling pathway	P01415	MAPKAPK2/3	MOUSE|MGI=MGI=109298|UniProtKB=P49138	MAP kinase-activated protein kinase 2	ISS	8262198	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P02738	De novo purine biosynthesis	P02907	dADP kinase	RAT|RGD=619877|UniProtKB=P19804	Nucleoside diphosphate kinase B	ISS			PTHR11349:SF57	NUCLEOSIDE DIPHOSPHATE KINASE B
P00009	Axon guidance mediated by netrin	P00359	NFAT	PANTR|Ensembl=ENSPTRG00000006218|UniProtKB=H2Q834	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P02723	Adenine and hypoxanthine salvage pathway	P02808	Deoxyadenosine phosphorylase	YEAST|SGD=S000004199|UniProtKB=Q05788	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=88397|UniProtKB=Q9ERZ4	Muscarinic acetylcholine receptor M2	IDA	8100450	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P04385	Histamine H1 receptor mediated signaling pathway	P04485	H1	RAT|RGD=2830|UniProtKB=P31390	Histamine H1 receptor	ISS	2670975	PubMed	PTHR43914:SF2	HISTAMINE H1 RECEPTOR
P00010	B cell activation	P00373	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IGI	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00012	Cadherin signaling pathway	P00463	betacatenin	PANTR|Ensembl=ENSPTRG00000023062|UniProtKB=H2R2U1	Catenin (Cadherin-associated protein), beta 1, 88kDa	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02746	Heme biosynthesis	P02979	porphobilinogen synthase	PANTR|Ensembl=ENSPTRG00000021279|UniProtKB=H2QXQ8	Delta-aminolevulinic acid dehydratase	ISS			PTHR11458:SF0	DELTA-AMINOLEVULINIC ACID DEHYDRATASE
P00018	EGF receptor signaling pathway	P00564	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	IPI	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00053	T cell activation	P01336	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IGI	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00046	Oxidative stress response	P01129	JNK1/2	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00025	Hedgehog signaling pathway	P00692	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00057	Wnt signaling pathway	P01438	PP2A	PANTR|Ensembl=ENSPTRG00000018180|UniProtKB=H2QT14	Protein phosphatase 2, regulatory subunit B', delta	ISS	96161994	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	MOUSE|MGI=MGI=87911|UniProtKB=P37172	Activin receptor type-1	TAS	9395284	PubMed	PTHR23255:SF69	ACTIVIN RECEPTOR TYPE-1
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DICDI|dictyBase=DDB_G0279413|UniProtKB=P05987	cAMP-dependent protein kinase regulatory subunit	IC	176910	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	RCA	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00057	Wnt signaling pathway	P01440	Cadherin	CHICK|Gene=CDH10|UniProtKB=P79995	Cadherin-10	IDA	8120095	PubMed	PTHR24027:SF290	CADHERIN-10
P02785	Valine biosynthesis	P03215	Branched chain amino acid aminotransferase	CAEEL|WormBase=WBGene00001149|UniProtKB=P54688	Branched-chain-amino-acid aminotransferase, cytosolic	ISS			PTHR11825:SF44	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P00029	Huntington disease	P00780	Microtubule	ORYSJ|EnsemblGenome=OS06G0671900|UniProtKB=Q40665	Tubulin beta-3 chain	IDA	9454836	PubMed	PTHR11588:SF245	TUBULIN BETA-4 CHAIN-RELATED
P00037	Ionotropic glutamate receptor pathway	P00998	stargazin	MOUSE|MGI=MGI=1316660|UniProtKB=O88602	Voltage-dependent calcium channel gamma-2 subunit	RCA			PTHR12107:SF1	VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-2 SUBUNIT
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00048	PI3 kinase pathway	P01181	GSK3	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00036	Interleukin signaling pathway	P00965	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00951	Jnk	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	XENTR|Xenbase=XB-GENE-491938|UniProtKB=Q6DIV8	Actin, alpha 1, skeletal muscle	ISS	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00029	Huntington disease	P00790	beta-Tubulin	YEAST|SGD=S000001857|UniProtKB=P02557	Tubulin beta chain	TAS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	IC	12488551	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00029	Huntington disease	P00790	beta-Tubulin	HUMAN|HGNC=20778|UniProtKB=P07437	Tubulin beta chain	TAS	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00046	Oxidative stress response	P01132	c-jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00053	T cell activation	P01322	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	IC	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00006	Apoptosis signaling pathway	P00302	ATF	PANTR|Ensembl=ENSPTRG00000012660|UniProtKB=H2QJ07	Activating transcription factor 2	ISS	10207617	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00048	PI3 kinase pathway	P01189	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00018	EGF receptor signaling pathway	P00562	p38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IGI	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00049	Parkinson disease	P01242	Casein kinase I	RAT|RGD=621408|UniProtKB=Q62763	Casein kinase I isoform gamma-3	IDA	10617630	PubMed	PTHR11909:SF151	CASEIN KINASE I ISOFORM GAMMA-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	TAKRU|Ensembl=ENSTRUG00000016241|UniProtKB=H2UX35	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF305	PROTEIN KINASE C
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00045	Notch signaling pathway	P01114	Ntm	MOUSE|MGI=MGI=97364|UniProtKB=O35516	Neurogenic locus notch homolog protein 2	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P04398	p53 pathway feedback loops 2	P04664	cyclin E	MACMU|Ensembl=ENSMMUG00000020668|UniProtKB=F7BEI4	Uncharacterized protein	ISS	12729791	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	ORYSJ|EnsemblGenome=OS01G0805900|UniProtKB=P45960	Tubulin beta-4 chain	ISS	9454836	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P00059	p53 pathway	P04633	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P06959	CCKR signaling map	P07110	PLC_beta	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	RCA	10930542	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00048	PI3 kinase pathway	P01203	p101	HUMAN|HGNC=30035|UniProtKB=Q8WYR1	Phosphoinositide 3-kinase regulatory subunit 5	IC	129387	gi	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00018	EGF receptor signaling pathway	P00551	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IGI	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02738	De novo purine biosynthesis	P02905	Amidophosphoribosyl transferase	AQUAE|EnsemblGenome=aq_1175|UniProtKB=O67236	Amidophosphoribosyltransferase	ISS			PTHR11907:SF0	AMIDOPHOSPHORIBOSYLTRANSFERASE
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01435	SWI/SNF	RAT|RGD=1561046|UniProtKB=D3ZIE5	Protein Smarca1	ISS	11532957	PubMed	PTHR10799:SF819	GLOBAL TRANSCRIPTION ACTIVATOR SNF2L1-RELATED
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	MOUSE|MGI=MGI=96828|UniProtKB=Q91ZX7	Prolow-density lipoprotein receptor-related protein 1	IDA	11907044	PubMed	PTHR44025:SF2	PROLOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1
P00049	Parkinson disease	P01242	Casein kinase I	MOUSE|MGI=MGI=1917675|UniProtKB=Q8C4X2	Casein kinase I isoform gamma-3	IDA	11437445	PubMed	PTHR11909:SF151	CASEIN KINASE I ISOFORM GAMMA-3
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05918	p38 MAPK pathway	P06034	MKK4	CANLF|Ensembl=ENSCAFG00000017851|UniProtKB=F1PBB6	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00049	Parkinson disease	P01209	19S proteasome	SCHPO|PomBase=SPAC607.05|UniProtKB=Q9US13	Probable 26S proteasome regulatory subunit rpn9	TAS	21848401	PubMed	PTHR10539:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	RCA	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_188187|UniProtKB=E9GJ31	Guanine nucleotide binding protein, q polypeptide	ISS	9166716	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001749|UniProtKB=H2Q0Q4	Uncharacterized protein	ISS	14624853	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00025	Hedgehog signaling pathway	P00682	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00223	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00049	Parkinson disease	P01215	Syntaxin	BOVIN|Ensembl=ENSBTAG00000001192|UniProtKB=A7MAZ2	STX12 protein	ISS	10321247	PubMed	PTHR19957:SF88	SYNTAXIN-12
P02721	ATP synthesis	P02791	F1 alpha	MONDO|Ensembl=ENSMODG00000003241|UniProtKB=F6THT5	ATP synthase subunit alpha	ISS	2527557	PubMed	PTHR43089:SF5	ATP SYNTHASE SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MONDO|Ensembl=ENSMODG00000014746|UniProtKB=F6YN64	Uncharacterized protein (Fragment)	ISS	12871085	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00010	B cell activation	P00398	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00049	Parkinson disease	P01242	Casein kinase I	RAT|RGD=62045|UniProtKB=Q99PS2	Casein kinase1 epsilon-2	IDA	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=1950|UniProtKB=P11229	Muscarinic acetylcholine receptor M1	IDA			PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00006	Apoptosis signaling pathway	P00274	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04398	p53 pathway feedback loops 2	P04661	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01457	GBeta	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IDA	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95774|UniProtKB=Q8CGK7	Guanine nucleotide-binding protein G(olf) subunit alpha	IC	14765990	PubMed	PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Ensembl=ENSPTRG00000004233|UniProtKB=H2Q4N9	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00004	Alzheimer disease-presenilin pathway	P00123	CD44 C-terminal fragment	PANTR|Ensembl=ENSPTRG00000003501|UniProtKB=H2Q3E8	Uncharacterized protein	ISS	14871815	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00029	Huntington disease	P00778	NMDA receptor	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	IDA	11319238	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04398	p53 pathway feedback loops 2	P04662	cyclin G	CANLF|Ensembl=ENSCAFG00000017207|UniProtKB=E2RSX2	Uncharacterized protein	ISS	7957050	PubMed	PTHR10177:SF59	CYCLIN-G1
P00048	PI3 kinase pathway	P01177	P110ACT	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DICDI|dictyBase=DDB_G0275023|UniProtKB=Q553U6	Putative actin-22	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	RCA	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P02728	Arginine biosynthesis	P02841	argininosuccinate lyase	SCHPO|PomBase=SPBC1773.14|UniProtKB=P40369	Argininosuccinate lyase	ISS			PTHR43814:SF1	ARGININOSUCCINATE LYASE
P00018	EGF receptor signaling pathway	P00547	PP2A	MOUSE|MGI=MGI=1321159|UniProtKB=P63330	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	CRYNJ|Gene=CNJ01940|UniProtKB=Q07801	Dihydrofolate reductase	ISS			PTHR22778:SF16	DIHYDROFOLATE REDUCTASE
P00056	VEGF signaling pathway	P01423	p38MAPK	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CHICK|Ensembl=ENSGALG00000015434|UniProtKB=F1NU20	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04453	ACTH	RAT|RGD=3366|UniProtKB=P01194	Pro-opiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CHICK|Gene=ACTA2|UniProtKB=P08023	Actin, aortic smooth muscle	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05917	Opioid proopiomelanocortin pathway	P06011	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00046	Oxidative stress response	P01129	JNK1/2	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04398	p53 pathway feedback loops 2	G04714	PTEN	HUMAN|HGNC=12023|UniProtKB=P56180	Putative tyrosine-protein phosphatase TPTE	IGI			PTHR12305:SF32	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE TPTE2-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	CAEEL|WormBase=WBGene00004769|UniProtKB=P52166	Presenilin sel-12	IDA	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00022	General transcription by RNA polymerase I	P00652	RNA Polymerase I  Complex	DANRE|ZFIN=ZDB-GENE-070820-18|UniProtKB=F1RDV9	Uncharacterized protein	ISS	12634356	PubMed	PTHR12056:SF2	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC4
P00057	Wnt signaling pathway	P01433	SIAH-1	PANTR|Ensembl=ENSPTRG00000015532|UniProtKB=H2QNL0	E3 ubiquitin-protein ligase	ISS			PTHR10315:SF11	E3 UBIQUITIN-PROTEIN LIGASE SIAH2
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	ORNAN|Ensembl=ENSOANG00000010187|UniProtKB=F7E0A0	Uncharacterized protein	ISS	14570579	PubMed	PTHR19957:SF90	SYNTAXIN-7
P04397	p53 pathway by glucose deprivation	P04636	S6K	PANTR|Ensembl=ENSPTRG00000003957|UniProtKB=H2Q486	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	HALSA|EnsemblGenome=VNG_6438G|UniProtKB=Q9HHE9	TATA-box-binding protein F	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00018	EGF receptor signaling pathway	P00545	JNK1-3	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=61801|UniProtKB=P30994	5-hydroxytryptamine receptor 2B	IDA			PTHR24247:SF31	5-HYDROXYTRYPTAMINE RECEPTOR 2B
P02763	Peptidoglycan biosynthesis	P03086	N-acetylglucosamine-1-phosphate uridyltransferase	THEMA|EnsemblGenome=TM_1629|UniProtKB=Q9X1W4	Bifunctional protein GlmU	ISS			PTHR43584:SF3	BIFUNCTIONAL PROTEIN GLMU
P00029	Huntington disease	P00778	NMDA receptor	RAT|RGD=621705|UniProtKB=Q8VHN2	Glutamate receptor ionotropic, NMDA 3B	IDA	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P02738	De novo purine biosynthesis	P02909	GDP reductase	CHICK|Ensembl=ENSGALG00000016049|UniProtKB=F1P0T9	Uncharacterized protein	ISS			PTHR23409:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 B
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	DROME|FlyBase=FBgn0010399|UniProtKB=Q24418	Glutamate [NMDA] receptor subunit 1	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P02730	Asparagine and aspartate biosynthesis	P02853	Asparagine synthetase	ARATH|TAIR=AT3G47340|UniProtKB=P49078	Asparagine synthetase [glutamine-hydrolyzing] 1	ISS			PTHR11772:SF2	ASPARAGINE SYNTHETASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00010	B cell activation	P00381	Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	IGI	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00019	Endothelin signaling pathway	P00573	signal peptidase	MOUSE|MGI=MGI=1913536|UniProtKB=Q9D8V7	Signal peptidase complex catalytic subunit SEC11C	ISS	2092035	PubMed	PTHR10806:SF12	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11C
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00029	Huntington disease	P00807	Actin	ORYSJ|EnsemblGenome=OS11G0163100|UniProtKB=Q67G20	Actin	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00053	T cell activation	P01319	PAK	XENTR|Xenbase=XB-GENE-961764|UniProtKB=F6W3Y0	Uncharacterized protein	ISS	11259591	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P04379	Beta3 adrenergic receptor signaling pathway	P04449	Beta3	PANTR|Ensembl=ENSPTRG00000024086|UniProtKB=H2R1M3	Uncharacterized protein	ISS	12063255	PubMed	PTHR24248:SF3	BETA-3 ADRENERGIC RECEPTOR
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	IDA	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00034	Integrin signalling pathway	P00912	Arp2/3	HUMAN|HGNC=708|UniProtKB=O15511	Actin-related protein 2/3 complex subunit 5	IPI	12473693	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	IDA	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	PANTR|Gene=DRD2|UniProtKB=P60026	D(2) dopamine receptor	ISS	1319557	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MOUSE|MGI=MGI=95777|UniProtKB=Q6R0H7	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas	ISS	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00048	PI3 kinase pathway	P01177	P110ACT	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00005	Angiogenesis	P00193	SOS-1	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02775	Salvage pyrimidine ribonucleotides	P03151	Uracil phosphoribosyl  transferase	ARATH|TAIR=AT3G53900|UniProtKB=Q9M336	Uracil phosphoribosyltransferase, chloroplastic	ISS			PTHR10285:SF46	URACIL PHOSPHORIBOSYLTRANSFERASE, CHLOROPLASTIC
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00052	TGF-beta signaling pathway	P01275	P38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	TAS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00045	Notch signaling pathway	P01109	Aph-1	MACMU|Ensembl=ENSMMUG00000017856|UniProtKB=F7DK04	Uncharacterized protein	ISS	12110170	PubMed	PTHR12889:SF1	GAMMA-SECRETASE SUBUNIT APH-1B
P00053	T cell activation	P01306	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00539	14-3-3	CANLF|Ensembl=ENSCAFG00000000580|UniProtKB=F1PBL1	Uncharacterized protein	ISS	12615066	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00018	EGF receptor signaling pathway	P00549	EGF	PANTR|Ensembl=ENSPTRG00000002689|UniProtKB=H2RE16	Uncharacterized protein	RCA			PTHR11100:SF18	PRO-NEUREGULIN-3, MEMBRANE-BOUND ISOFORM
P04393	Ras Pathway	P04559	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	10802295	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P05731	GABA-B receptor II signaling	P05754	Ggamma	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	RCA	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00036	Interleukin signaling pathway	P00977	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	BOVIN|Ensembl=ENSBTAG00000047202|UniProtKB=G3N3K3	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IDA	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	RAT|RGD=2026|UniProtKB=P68035	Actin, alpha cardiac muscle 1	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00056	VEGF signaling pathway	P01409	cPLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P06959	CCKR signaling map	G06977	PAI2	HUMAN|HGNC=8584|UniProtKB=P05120	Plasminogen activator inhibitor 2	RCA	12105855	PubMed	PTHR11461:SF61	PLASMINOGEN ACTIVATOR INHIBITOR 2
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	HUMAN|HGNC=10934|UniProtKB=P54219	Chromaffin granule amine transporter	ISS	92370677	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	MOUSE|MGI=MGI=1347062|UniProtKB=Q9Z125	Cyclic AMP-responsive element-binding protein 3-like protein 1	RCA			PTHR22952:SF24	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 1
P00047	PDGF signaling pathway	P01153	GSK3	BOVIN|Ensembl=ENSBTAG00000020756|UniProtKB=A6QLB8	GSK3A protein	ISS	2164470	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00036	Interleukin signaling pathway	P00973	PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00556	PLCgamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00049	Parkinson disease	P01227	20S proteasome	PHYPA|Gene=PHYPADRAFT_127390|UniProtKB=A9SCK2	Proteasome subunit alpha type (Fragment)	TAS	12859888	PubMed	PTHR11599:SF14	PROTEASOME SUBUNIT ALPHA TYPE-5
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	BOVIN|Gene=ARPC5|UniProtKB=Q3SYX9	Actin-related protein 2/3 complex subunit 5	IDA	10322212	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	HUMAN|HGNC=1955|UniProtKB=P02708	Acetylcholine receptor subunit alpha	IC	85270494	PubMed	PTHR18945:SF74	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00049	Parkinson disease	P01224	UbcH7	MACMU|Ensembl=ENSMMUG00000008940|UniProtKB=F7EVY1	Uncharacterized protein	RCA			PTHR24068:SF67	UBIQUITIN-CONJUGATING ENZYME E2 L3
P00018	EGF receptor signaling pathway	P00557	PI3K	ARATH|TAIR=AT1G60490|UniProtKB=P42339	Phosphatidylinositol 3-kinase VPS34	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00059	p53 pathway	P01486	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	TAS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00541	Spry	RAT|RGD=1305324|UniProtKB=D3ZJA3	Protein Spry4	ISS	10330503	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	MONDO|Ensembl=ENSMODG00000015399|UniProtKB=F6T507	Uncharacterized protein	ISS	94365697	PubMed	PTHR11958:SF69	EXCITATORY AMINO ACID TRANSPORTER 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	8270251	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00046	Oxidative stress response	P01132	c-jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00260	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04395	Vasopressin synthesis	P04594	Neurophysin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00045	Notch signaling pathway	P01109	Aph-1	CANLF|Ensembl=ENSCAFG00000011777|UniProtKB=E2R5H5	Anterior pharynx defective 1 homolog A	ISS	12110170	PubMed	PTHR12889:SF3	GAMMA-SECRETASE SUBUNIT APH-1A
P00060	Ubiquitin proteasome pathway	P01491	E2	DROME|FlyBase=FBgn0011217|UniProtKB=P25867	Ubiquitin-conjugating enzyme E2-17 kDa	ISS			PTHR24068:SF74	FI16911P1-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01329	CD45	PANTR|Ensembl=ENSPTRG00000001817|UniProtKB=H2Q0U9	Uncharacterized protein	ISS	1672451	PubMed	PTHR19134:SF284	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	RAT|RGD=620977|UniProtKB=G3V7P1	Syntaxin-12	ISS	14570579	PubMed	PTHR19957:SF88	SYNTAXIN-12
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	IC	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00702	CPB	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	RCA			PTHR13808:SF5	CREB-BINDING PROTEIN
P00018	EGF receptor signaling pathway	P00561	STAT	MONDO|Ensembl=ENSMODG00000014836|UniProtKB=F7D2D3	Signal transducer and activator of transcription	ISS	96102059	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00005	Angiogenesis	P00218	STAT1	HUMAN|HGNC=11362|UniProtKB=P42224	Signal transducer and activator of transcription 1-alpha/beta	IDA	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00012	Cadherin signaling pathway	P00475	Frizzled	ANOGA|EnsemblGenome=AGAP010442|UniProtKB=Q7QDV6	AGAP010442-PA	ISS	11212302	PubMed	PTHR11309:SF90	FRIZZLED-8
P00009	Axon guidance mediated by netrin	P00366	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00628	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	PANTR|Ensembl=ENSPTRG00000017345|UniProtKB=H2QRN4	TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa	ISS			PTHR12228:SF6	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 7
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	XENTR|Ensembl=ENSXETG00000030140|UniProtKB=F7EP58	Uncharacterized protein (Fragment)	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02916	dTMP kinase	SULSO|EnsemblGenome=SSO0780|UniProtKB=Q9UXG7	Probable thymidylate kinase 1	ISS			PTHR10344:SF1	THYMIDYLATE KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00047	PDGF signaling pathway	P01146	Ikk	HUMAN|HGNC=1974|UniProtKB=O15111	Inhibitor of nuclear factor kappa-B kinase subunit alpha	RCA			PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00737	Rap1GAP	BOVIN|Ensembl=ENSBTAG00000008952|UniProtKB=Q08E64	RAP1 GTPase activating protein	ISS	10419452	PubMed	PTHR15711:SF3	RAP1 GTPASE-ACTIVATING PROTEIN 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06812	L-type Ca2+	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	RCA	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TRIVA|Gene=TVAG_054030|UniProtKB=A2G1K5	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MACMU|Ensembl=ENSMMUG00000019342|UniProtKB=F6PVY4	Uncharacterized protein	ISS	12932731	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-8225|UniProtKB=Q7SZZ5	Uncharacterized protein	ISS			PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00048	PI3 kinase pathway	P01192	p110	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05913	Enkephalin release	P05977	G-Protein (s)	CANLF|Ensembl=ENSCAFG00000028654|UniProtKB=J9P702	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00018	EGF receptor signaling pathway	P00543	ERK1-2	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	ARATH|TAIR=AT1G51720|UniProtKB=F4I9M9	Amino acid dehydrogenase family protein	ISS			PTHR43571:SF1	NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED
P00034	Integrin signalling pathway	P00951	Jnk	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01202	p85	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00046	Oxidative stress response	P01121	MKK3/6	HUMAN|HGNC=6846|UniProtKB=P52564	Dual specificity mitogen-activated protein kinase kinase 6	RCA			PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P00018	EGF receptor signaling pathway	P00547	PP2A	XENTR|Xenbase=XB-GENE-1017127|UniProtKB=Q28GT8	Serine/threonine-protein phosphatase	ISS			PTHR11668:SF24	SERINE/THREONINE-PROTEIN PHOSPHATASE 6 CATALYTIC SUBUNIT
P04395	Vasopressin synthesis	P04593	Glycopeptide	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	IC	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P06959	CCKR signaling map	P07228	MAPK1/3	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	RCA	7943237	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02723	Adenine and hypoxanthine salvage pathway	P02812	Deoxyinosine phosphorylase	MOUSE|MGI=MGI=3712328|UniProtKB=Q9D8C9	Purine nucleoside phosphorylase	ISS	7903568	PubMed	PTHR11904:SF12	PURINE NUCLEOSIDE PHOSPHORYLASE
P00046	Oxidative stress response	P01129	JNK1/2	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00059	p53 pathway	P04614	Cyclin B	RAT|RGD=2291|UniProtKB=P30277	G2/mitotic-specific cyclin-B1	ISS	1019642	gi	PTHR10177:SF193	G2/MITOTIC-SPECIFIC CYCLIN-B1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00049	Parkinson disease	P01219	SAPK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04393	Ras Pathway	P04545	Sec5	ORNAN|Ensembl=ENSOANG00000006327|UniProtKB=F6R680	Uncharacterized protein	ISS			PTHR13043:SF1	EXOCYST COMPLEX COMPONENT 2
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05970	TH	CHICK|Ensembl=ENSGALG00000006551|UniProtKB=F6RRW6	Uncharacterized protein	ISS	12480184	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00005	Angiogenesis	P00238	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P02781	Threonine biosynthesis	P03190	Threonine synthase	MACMU|Ensembl=ENSMMUG00000022383|UniProtKB=F7H191	Threonine synthase-like 1	ISS			PTHR43515:SF1	THREONINE SYNTHASE-LIKE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	MOUSE|MGI=MGI=98259|UniProtKB=P10148	C-C motif chemokine 2	ISS			PTHR12015:SF117	C-C MOTIF CHEMOKINE 2
P00056	VEGF signaling pathway	P01413	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01148	Grb2	RAT|RGD=619758|UniProtKB=P62994	Growth factor receptor-bound protein 2	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00047	PDGF signaling pathway	P01140	ELK	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	11279280	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00029	Huntington disease	P00807	Actin	DROME|FlyBase=FBgn0000047|UniProtKB=P83967	Actin, indirect flight muscle	IDA	14684598	PubMed	PTHR11937:SF368	ACTIN, INDIRECT FLIGHT MUSCLE
P00018	EGF receptor signaling pathway	P00551	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IGI	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	DROME|FlyBase=FBgn0004177|UniProtKB=P23696	Serine/threonine-protein phosphatase PP2A	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00024	Glycolysis	P00679	Aldolase	CHICK|Ensembl=ENSGALG00000015544|UniProtKB=P07341	Fructose-bisphosphate aldolase B	ISS	2985560	PubMed	PTHR11627:SF2	FRUCTOSE-BISPHOSPHATE ALDOLASE B
P02727	Androgen/estrogene/progesterone biosynthesis	P02826	Estradiol 17beta-dehydrogenase	HUMAN|HGNC=23316|UniProtKB=O14756	17-beta-hydroxysteroid dehydrogenase type 6	RCA			PTHR43313:SF4	17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 6
P00018	EGF receptor signaling pathway	P00547	PP2A	MONDO|Ensembl=ENSMODG00000019007|UniProtKB=F7C5Z9	Uncharacterized protein	ISS	12110603	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	HUMAN|HGNC=10632|UniProtKB=P13501	C-C motif chemokine 5	ISS	250208	gi	PTHR12015:SF82	C-C MOTIF CHEMOKINE 5
P04393	Ras Pathway	P04541	p90RSK	CHICK|Ensembl=ENSGALG00000016406|UniProtKB=F1NLJ3	Uncharacterized protein	ISS	10480933	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CHICK|Gene=CHRND|UniProtKB=P02717	Acetylcholine receptor subunit delta	IC	85203892	PubMed	PTHR18945:SF61	ACETYLCHOLINE RECEPTOR SUBUNIT DELTA
P00030	Hypoxia response via HIF activation	P00819	AKT	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00018	EGF receptor signaling pathway	P00551	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00249	PAK	MONDO|Ensembl=ENSMODG00000005255|UniProtKB=F7G800	Uncharacterized protein	ISS	11259591	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P02777	Succinate to proprionate conversion	P03161	Methylmalonyl-CoA mutase	CANLF|Ensembl=ENSCAFG00000002111|UniProtKB=E2RKY4	Uncharacterized protein	ISS			PTHR42710:SF1	METHYLMALONYL-COA MUTASE, MITOCHONDRIAL
P05918	p38 MAPK pathway	P06030	IL-1R	RAT|RGD=2892|UniProtKB=Q02955	Interleukin-1 receptor type 1	RCA			PTHR11890:SF26	INTERLEUKIN-1 RECEPTOR TYPE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	ISS	1650351	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	IC	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00048	PI3 kinase pathway	P01177	P110ACT	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	PANTR|Ensembl=ENSPTRG00000005449|UniProtKB=H2Q6V7	Serine/threonine-protein phosphatase	ISS	8392016	PubMed	PTHR11668:SF377	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-ALPHA CATALYTIC SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00777	CBP	CAEEL|WormBase=WBGene00000366|UniProtKB=P34545	Protein cbp-1	IDA	8413673	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00029	Huntington disease	P00788	Calpain	BOVIN|Ensembl=ENSBTAG00000005034|UniProtKB=F1MQD1	Uncharacterized protein	ISS	11675509	PubMed	PTHR10183:SF370	CALPAIN-5
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	BOVIN|Ensembl=ENSBTAG00000030182|UniProtKB=G3X793	Mitogen-activated protein kinase	ISS	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	HUMAN|HGNC=7155|UniProtKB=P03956	Interstitial collagenase	TAS	3009463	PubMed	PTHR10201:SF151	INTERSTITIAL COLLAGENASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IC	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	SCHMA|EnsemblGenome=Smp_183710|UniProtKB=G4VLW1	Putative actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1203729|UniProtKB=Q61194	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00916	Ras	BOVIN|Ensembl=ENSBTAG00000009778|UniProtKB=E1BMX0	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00003	Alzheimer disease-amyloid secretase pathway	P00079	alpha7 nicotinic acetylcholine receptor	DROME|FlyBase=FBgn0028875|UniProtKB=Q7KT97	Nicotinic acetylcholine receptor alpha5, isoform B	IDA			PTHR18945:SF770	NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA5, ISOFORM B
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	IDA	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P05913	Enkephalin release	P05977	G-Protein (s)	MONDO|Ensembl=ENSMODG00000005623|UniProtKB=F7CFG8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01153	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04397	p53 pathway by glucose deprivation	P04640	p53	HUMAN|HGNC=11998|UniProtKB=P04637	Cellular tumor antigen p53	TAS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00047	PDGF signaling pathway	P01151	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04564	MAPKAP	PANTR|Ensembl=ENSPTRG00000001915|UniProtKB=H2Q104	Mitogen-activated protein kinase-activated protein kinase 2	ISS	7923354	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00057	Wnt signaling pathway	P01444	Wnt	MACMU|Ensembl=ENSMMUG00000002439|UniProtKB=F6PJN8	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	TAS	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P04393	Ras Pathway	P04556	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IDA	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000013587|UniProtKB=F7AZ16	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF33	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-3
P00059	p53 pathway	G01579	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00052	TGF-beta signaling pathway	P01275	P38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	TAS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01438	PP2A	STRPU|EnsemblGenome=SPU_025182|UniProtKB=W4ZAK5	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	DICDI|dictyBase=DDB_G0279407|UniProtKB=P02599	Calmodulin	ISS	10487978	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	PANTR|Ensembl=ENSPTRG00000011718|UniProtKB=H2QHJ5	Adenylate cyclase 3	ISS	2255909	PubMed	PTHR11920:SF291	ADENYLATE CYCLASE TYPE 3
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00010	B cell activation	P00383	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00019	Endothelin signaling pathway	P00585	ECE1-3	CANLF|Ensembl=ENSCAFG00000014920|UniProtKB=F1PK66	Uncharacterized protein	ISS	94340737	PubMed	PTHR11733:SF130	ENDOTHELIN-CONVERTING ENZYME 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05916	Opioid prodynorphin pathway	P06000	vasopressin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	MACMU|Ensembl=ENSMMUG00000004329|UniProtKB=F6ZDV3	Excitatory amino acid transporter 2 isoform 1	ISS	96032356	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P00055	Transcription regulation by bZIP transcription factor	P01389	TTF2	HUMAN|HGNC=12398|UniProtKB=Q9UNY4	Transcription termination factor 2	RCA			PTHR10799:SF834	TRANSCRIPTION TERMINATION FACTOR 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS			PTHR13808:SF5	CREB-BINDING PROTEIN
P00038	JAK/STAT signaling pathway	P01034	Jak	BOVIN|Ensembl=ENSBTAG00000020904|UniProtKB=E1BEL4	Tyrosine-protein kinase	ISS	15179321	PubMed	PTHR24418:SF233	TYROSINE-PROTEIN KINASE JAK3
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00048	PI3 kinase pathway	P01181	GSK3	STRPU|EnsemblGenome=SPU_009263|UniProtKB=W4Y0P1	Uncharacterized protein	ISS	9609832	PubMed	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00019	Endothelin signaling pathway	P00587	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	BOVIN|Ensembl=ENSBTAG00000034854|UniProtKB=F1N246	Uncharacterized protein	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00046	Oxidative stress response	P01122	TRX	CAEEL|WormBase=WBGene00010160|UniProtKB=Q9TW67	Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase	ISS			PTHR12143:SF19	PEPTIDE-N 4 - N-ACETYL-BETA-GLUCOSAMINYL ASPARAGINE AMIDASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	CANLF|Ensembl=ENSCAFG00000005109|UniProtKB=Q3LSL6	C-X-C chemokine receptor type 4	ISS	11591799	PubMed	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P06959	CCKR signaling map	P07228	MAPK1/3	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	RCA	12488236	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	HUMAN|HGNC=4404|UniProtKB=P59768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IDA	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P05917	Opioid proopiomelanocortin pathway	P06006	beta-Endorphin	PANTR|Ensembl=ENSPTRG00000011721|UniProtKB=H2R8Y3	Uncharacterized protein	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00038	JAK/STAT signaling pathway	P01027	STAT	TAKRU|Ensembl=ENSTRUG00000000102|UniProtKB=H2RJA9	Signal transducer and activator of transcription	ISS	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00045	Notch signaling pathway	P01116	Delta	RAT|RGD=70949|UniProtKB=P97677	Delta-like protein 1	ISS	12175503	PubMed	PTHR24044:SF380	DELTA-LIKE PROTEIN 1
P00021	FGF signaling pathway	P00640	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00980	IRS1/2	HUMAN|HGNC=6125|UniProtKB=P35568	Insulin receptor substrate 1	IC	1311924	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P02738	De novo purine biosynthesis	P02909	GDP reductase	PYRAE|EnsemblGenome=PAE3155|UniProtKB=Q8ZTP7	Ribonucleotide reductase	ISS			PTHR43371:SF1	SUBFAMILY NOT NAMED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000009085|UniProtKB=H2RDQ2	Uncharacterized protein	ISS	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00053	T cell activation	P01312	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00006	Apoptosis signaling pathway	P00269	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IDA	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CHICK|Ensembl=ENSGALG00000017178|UniProtKB=F1N982	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00035	Interferon-gamma signaling pathway	P00954	Interferongamma	CHICK|Ensembl=ENSGALG00000009903|UniProtKB=P49708	Interferon gamma	TAS	11175845	PubMed	PTHR11419:SF0	INTERFERON GAMMA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CAEEL|WormBase=WBGene00000063|UniProtKB=P0DM41	Actin-1	IC	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P05913	Enkephalin release	P05978	AC	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	YEAST|SGD=S000005562|UniProtKB=P32854	Syntaxin PEP12	IC			PTHR19957:SF38	T-SNARE DOMAIN-CONTAINING PROTEIN 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00036	Interleukin signaling pathway	P00972	MNK1/2	MACMU|Ensembl=ENSMMUG00000011265|UniProtKB=F6WP09	Uncharacterized protein	ISS	9155017	PubMed	PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MACMU|Ensembl=ENSMMUG00000019112|UniProtKB=F6T8S6	N-methyl D-aspartate receptor subtype 2B	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00029	Huntington disease	P00785	Cytochrome c	IXOSC|EnsemblGenome=ISCW016731|UniProtKB=B7P8B3	Cytochrome c1, putative	ISS	15163634	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00057	Wnt signaling pathway	P01428	Frizzled	CHICK|Ensembl=ENSGALG00000017242|UniProtKB=Q9IA05	Frizzled-4	IDA	11212302	PubMed	PTHR11309:SF23	FRIZZLED-4
P00005	Angiogenesis	P00181	SHP2	CANLF|Ensembl=ENSCAFG00000008894|UniProtKB=F1Q3J6	Tyrosine-protein phosphatase non-receptor type	ISS	95163101	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	IC	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00025	Hedgehog signaling pathway	P00686	Fused	DROME|FlyBase=FBgn0001079|UniProtKB=P23647	Serine/threonine-protein kinase fused	ISS			PTHR22983:SF6	SERINE/THREONINE-PROTEIN KINASE 36
P00009	Axon guidance mediated by netrin	P00363	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P02748	Isoleucine biosynthesis	P02995	Threonine dehydratase	HALSA|EnsemblGenome=VNG_2100G|UniProtKB=Q9HNH6	Threonine dehydratase	ISS			PTHR43419:SF8	THREONINE AMMONIA-LYASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	ANOGA|EnsemblGenome=AGAP004613|UniProtKB=Q7Q7P1	AGAP004613-PA (Fragment)	IDA			PTHR43893:SF6	DOPAMINE RECEPTOR 1
P00045	Notch signaling pathway	P01103	Next	BOVIN|Ensembl=ENSBTAG00000012817|UniProtKB=E1BDN7	Delta-like protein	ISS	8955070	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	TAKRU|Ensembl=ENSTRUG00000006464|UniProtKB=H2STT5	Uncharacterized protein	ISS	1904317	PubMed	PTHR24070:SF382	RAS-RELATED PROTEIN RAP-1B
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00009	Axon guidance mediated by netrin	P00356	UNC-5	CANLF|Ensembl=ENSCAFG00000006252|UniProtKB=F1Q2N1	Uncharacterized protein	ISS			PTHR12582:SF5	NETRIN RECEPTOR UNC5D
P02775	Salvage pyrimidine ribonucleotides	P03149	Cytidine kinase	CHICK|Ensembl=ENSGALG00000003510|UniProtKB=F1NMM9	Uridine-cytidine kinase	ISS			PTHR10285:SF70	URIDINE-CYTIDINE KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	SCHMA|EnsemblGenome=Smp_202970|UniProtKB=G4VLN1	Putative uncharacterized protein Smp_202970	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000023202|UniProtKB=F7EU36	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00029	Huntington disease	P00797	p53	CHICK|Ensembl=ENSGALG00000007324|UniProtKB=F1N8Z7	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00586	Gq	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00056	VEGF signaling pathway	P01407	Erk	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01472	Histone deacetylase	EMENI|EnsemblGenome=CADANIAG00004906|UniProtKB=Q5B6M4	Histone deacetylase	IDA	10485845	PubMed	PTHR10625:SF132	HISTONE DEACETYLASE 3
P00005	Angiogenesis	P00221	JNK1	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01173	STAT	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	ISS	12191995	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	MOUSE|MGI=MGI=1929772|UniProtKB=Q9EQF6	Dihydropyrimidinase-related protein 5	IPI	10851247	PubMed	PTHR11647:SF58	DIHYDROPYRIMIDINASE-RELATED PROTEIN 5
P00056	VEGF signaling pathway	P01407	Erk	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05913	Enkephalin release	P05972	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00049	Parkinson disease	P01227	20S proteasome	CAEEL|WormBase=WBGene00003949|UniProtKB=Q23237	Proteasome subunit beta type-3	TAS	12859888	PubMed	PTHR11599:SF62	PROTEASOME SUBUNIT BETA TYPE-3
P00001	Adrenaline and noradrenaline biosynthesis	P00068	amine translocator	RAT|RGD=69352|UniProtKB=Q62687	Sodium-dependent neutral amino acid transporter B(0)AT3	IC	12719981	PubMed	PTHR11616:SF109	SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER B 0 AT3
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	CHICK|Ensembl=ENSGALG00000016308|UniProtKB=P01109	Myc proto-oncogene protein	IEP	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	10188796	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P00998	stargazin	HUMAN|HGNC=1409|UniProtKB=Q9UF02	Voltage-dependent calcium channel gamma-5 subunit	ISS	11140673	PubMed	PTHR12107:SF4	VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-5 SUBUNIT
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	MACMU|Ensembl=ENSMMUG00000011769|UniProtKB=F7HQK5	Uncharacterized protein	ISS			PTHR10943:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00047	PDGF signaling pathway	P01160	IP3 receptor	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	METJA|EnsemblGenome=MJ_0001|UniProtKB=Q60317	Probable aspartate aminotransferase	ISS			PTHR11751:SF430	SUBFAMILY NOT NAMED
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TRIVA|Gene=TVAG_090470|UniProtKB=A2FA04	Actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Gene=DRD2|UniProtKB=P20288	D(2) dopamine receptor	IDA	11248120	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00057	Wnt signaling pathway	P01444	Wnt	MACMU|Ensembl=ENSMMUG00000004904|UniProtKB=F7CJE4	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P00015	Circadian clock system	G01499	per	CHICK|Gene=PER2|UniProtKB=Q8QGQ8	Period circadian protein homolog 2	IEP	21236844	PubMed	PTHR11269:SF9	PERIOD CIRCADIAN PROTEIN HOMOLOG 2
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02741	Flavin biosynthesis	P02934	Riboflavin kinase	THEMA|EnsemblGenome=TM_0857|UniProtKB=Q9WZW1	Riboflavin biosynthesis protein	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P00034	Integrin signalling pathway	P00941	Integrin alpha	MACMU|Ensembl=ENSMMUG00000012659|UniProtKB=F7E7I7	Uncharacterized protein	ISS	3487386	PubMed	PTHR23220:SF73	INTEGRIN ALPHA-IIB
P00006	Apoptosis signaling pathway	P00259	TNF	HUMAN|HGNC=6711|UniProtKB=Q06643	Lymphotoxin-beta	IDA	1908877	PubMed	PTHR11471:SF29	LYMPHOTOXIN-BETA
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	PANTR|Ensembl=ENSPTRG00000019627|UniProtKB=H2QVA4	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00020	FAS signaling pathway	P00615	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PANTR|Ensembl=ENSPTRG00000002371|UniProtKB=H2Q1R1	Uncharacterized protein	ISS	22028976	PubMed	PTHR13140:SF387	MYOSIN-IIIA
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	XENTR|Xenbase=XB-GENE-977853|UniProtKB=F7EBE7	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	MOUSE|MGI=MGI=96433|UniProtKB=Q60751	Insulin-like growth factor 1 receptor	ISS	249616	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00012	Cadherin signaling pathway	P00465	TCF/LEF	BOVIN|Ensembl=ENSBTAG00000010111|UniProtKB=F1MJS2	Uncharacterized protein	ISS	9118222	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00021	FGF signaling pathway	P00629	PP2A	MOUSE|MGI=MGI=1920949|UniProtKB=Q7TNP2	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform	ISS			PTHR10648:SF9	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 65 KDA REGULATORY SUBUNIT A BETA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PHYPA|Gene=PHYPADRAFT_225906|UniProtKB=A9TVP1	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	CANLF|Ensembl=ENSCAFG00000006453|UniProtKB=F6X958	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01173	STAT	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	ISS	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00018	EGF receptor signaling pathway	P00561	STAT	PANTR|Ensembl=ENSPTRG00000009200|UniProtKB=H2QD20	Signal transducer and activator of transcription	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00023	General transcription regulation	P00669	TFIIEalpha	RAT|RGD=1306851|UniProtKB=G3V992	General transcription factor II E, polypeptide 1 (Alpha subunit)	ISS	189964	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00254	GTPase	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	ISS	15668138	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00056	VEGF signaling pathway	P01411	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P05913	Enkephalin release	P05978	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02763	Peptidoglycan biosynthesis	P03088	UDP-N-acetylmuramate dehydrogenase	BACTN|EnsemblGenome=BT_1368|UniProtKB=Q8A806	UDP-N-acetylenolpyruvoylglucosamine reductase	ISS			PTHR21071:SF4	UDP-N-ACETYLENOLPYRUVOYLGLUCOSAMINE REDUCTASE
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	HUMAN|HGNC=5299|UniProtKB=Q13639	5-hydroxytryptamine receptor 4	IDA	12898568	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00036	Interleukin signaling pathway	P00983	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04662	cyclin G	MACMU|Ensembl=ENSMMUG00000019550|UniProtKB=F7CKQ1	Uncharacterized protein	ISS	11983168	PubMed	PTHR10177:SF59	CYCLIN-G1
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=68438|UniProtKB=P35370	Nociceptin receptor	IDA	11259487	PubMed	PTHR24229:SF11	NOCICEPTIN RECEPTOR
P00010	B cell activation	P00391	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00219	PKC	RAT|RGD=1310236|UniProtKB=D4A229	Serine/threonine-protein kinase	ISS	12676944	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-486685|UniProtKB=F6VT32	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	IXOSC|EnsemblGenome=ISCW017136|UniProtKB=B7PA95	Beta tubulin	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	YEAST|SGD=S000000028|UniProtKB=P31109	Synaptobrevin homolog 1	ISS	10414292	PubMed	PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000009626|UniProtKB=F6ZYQ0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MONDO|Ensembl=ENSMODG00000017550|UniProtKB=F7E0Z1	Uncharacterized protein	ISS	10321247	PubMed	PTHR19957:SF90	SYNTAXIN-7
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00012	Cadherin signaling pathway	P00468	Src	RAT|RGD=620795|UniProtKB=Q9WUD9	Proto-oncogene tyrosine-protein kinase Src	ISS	11078745	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P05918	p38 MAPK pathway	P06020	p38delta	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	RCA	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00011	Blood coagulation	P00404	PAR-1	HUMAN|HGNC=3537|UniProtKB=P25116	Proteinase-activated receptor 1	ISS	3024720	gi	PTHR24232:SF20	PROTEINASE-ACTIVATED RECEPTOR 1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	TAS	1169551	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00046	Oxidative stress response	P01135	p38	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	TAS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06773	gnai/o	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00183	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	ASHGO|EnsemblGenome=AGOS_AGL093W|UniProtKB=Q9HF56	Cell division control protein 42	ISS	11156982	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00036	Interleukin signaling pathway	P00973	PKB	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04398	p53 pathway feedback loops 2	P04665	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01434	sFRP	BOVIN|Gene=SFRP1|UniProtKB=O19116	Secreted frizzled-related protein 1	ISS	9096311	PubMed	PTHR11309:SF87	SECRETED FRIZZLED-RELATED PROTEIN 1
P00053	T cell activation	P01307	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DROME|FlyBase=FBgn0259680|UniProtKB=P83099	Putative protein kinase C delta type homolog	IC	3045562	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	PANTR|Ensembl=ENSPTRG00000001995|UniProtKB=H2Q156	Glutamyl-prolyl-tRNA synthetase	ISS			PTHR43382:SF2	BIFUNCTIONAL GLUTAMATE/PROLINE--TRNA LIGASE
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	RAT|RGD=621060|UniProtKB=O88777	Presenilin-2	IDA	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DANRE|ZFIN=ZDB-GENE-041210-195|UniProtKB=F1R506	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00025	Hedgehog signaling pathway	P00691	CBP	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00057	Wnt signaling pathway	P01448	CBP	HUMAN|HGNC=3373|UniProtKB=Q09472	Histone acetyltransferase p300	IDA	10664585	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	ISS	10514528	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ORYSJ|EnsemblGenome=OS10G0510000|UniProtKB=A3C6D7	Actin-2	IC	14684598	PubMed	PTHR11937:SF252	SUBFAMILY NOT NAMED
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IC	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02723	Adenine and hypoxanthine salvage pathway	P02805	Adenine phosphorylase	THEMA|EnsemblGenome=TM_1596|UniProtKB=Q9X1T2	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MACMU|Ensembl=ENSMMUG00000014597|UniProtKB=F6VAQ6	Glycogen synthase kinase-3 alpha	ISS	21361340	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00059	p53 pathway	G04694	p110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00030	Hypoxia response via HIF activation	P00819	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	TAS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01331	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01443	Phospholipase C	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	RAT|RGD=2734|UniProtKB=Q01812	Glutamate receptor ionotropic, kainate 4	ISS	12778120	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	TAKRU|Ensembl=ENSTRUG00000017396|UniProtKB=H2V5T2	Uncharacterized protein	ISS			PTHR10943:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1
P05918	p38 MAPK pathway	P05921	MKP5	BOVIN|Ensembl=ENSBTAG00000001729|UniProtKB=Q0IID7	Dual specificity protein phosphatase 10	ISS	10597297	PubMed	PTHR10159:SF299	DUAL SPECIFICITY PROTEIN PHOSPHATASE 10
P02774	Salvage pyrimidine deoxyribonucleotides	P03145	Uracil phosphorylase	METJA|EnsemblGenome=MJ_0667|UniProtKB=Q58081	AMP phosphorylase	ISS	8688087	PubMed	PTHR10515:SF0	THYMIDINE PHOSPHORYLASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00007	Axon guidance mediated by semaphorins	P00331	PAK	MOUSE|MGI=MGI=1339975|UniProtKB=O88643	Serine/threonine-protein kinase PAK 1	IDA	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00046	Oxidative stress response	P01131	MKP5	PANTR|Ensembl=ENSPTRG00000022532|UniProtKB=H2R3E8	Uncharacterized protein	ISS			PTHR10159:SF25	INACTIVE DUAL SPECIFICITY PHOSPHATASE 27
P00036	Interleukin signaling pathway	P00990	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05731	GABA-B receptor II signaling	P05760	AC	BOVIN|Ensembl=ENSBTAG00000005464|UniProtKB=E1B9K3	Uncharacterized protein	ISS	92409599	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8684|UniProtKB=Q9Y5F0	Protocadherin beta-13	IDA	8120095	PubMed	PTHR24028:SF61	PROTOCADHERIN BETA-13
P04393	Ras Pathway	P04541	p90RSK	ORNAN|Ensembl=ENSOANG00000010658|UniProtKB=F6V2V1	Uncharacterized protein	ISS	6755374	gi	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00010	B cell activation	P00376	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00056	VEGF signaling pathway	P01402	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	RCA			PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P06587	Nicotine pharmacodynamics pathway	P06604	SLC18A2	MACMU|Ensembl=ENSMMUG00000014817|UniProtKB=F6VXD8	Uncharacterized protein	ISS	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00049	Parkinson disease	P01219	SAPK	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	ISS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00057	Wnt signaling pathway	P01446	Calcineurin	ARATH|TAIR=AT4G26560|UniProtKB=Q9SUA6	Calcineurin B-like protein 7	IDA	12015605	PubMed	PTHR23056:SF51	CALCINEURIN B-LIKE PROTEIN 2-RELATED
P00053	T cell activation	P01305	Calmodulin	MACMU|Ensembl=ENSMMUG00000017921|UniProtKB=F7EDG8	Uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF335	CALMODULIN, STRIATED MUSCLE
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	TAS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	CANLF|Ensembl=ENSCAFG00000013148|UniProtKB=Q5R1P3	Glutamate receptor ionotropic, NMDA 2B	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00009	Axon guidance mediated by netrin	P00358	Ablim	PANTR|Ensembl=ENSPTRG00000002961|UniProtKB=H2R0M2	Uncharacterized protein	ISS	602330	OMIM	PTHR24213:SF18	ACTIN-BINDING LIM PROTEIN 1
P00029	Huntington disease	P00778	NMDA receptor	CANLF|Ensembl=ENSCAFG00000013148|UniProtKB=Q5R1P3	Glutamate receptor ionotropic, NMDA 2B	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=69237|UniProtKB=Q9QYP2	Cadherin EGF LAG seven-pass G-type receptor 2 (Fragment)	ISS	8120095	PubMed	PTHR24026:SF32	CADHERIN EGF LAG SEVEN-PASS G-TYPE RECEPTOR 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MOUSE|MGI=MGI=108409|UniProtKB=O08899	Regulator of G-protein signaling 4	ISS	8756726	PubMed	PTHR10845:SF184	REGULATOR OF G-PROTEIN SIGNALING 4
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02750	Lipoate_biosynthesis	P03004	Lipoate synthase	LEIMA|Gene=LmjF19.0350|UniProtKB=Q4QDI6	Lipoyl synthase, mitochondrial	ISS			PTHR10949:SF0	LIPOYL SYNTHASE, MITOCHONDRIAL
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	TRYB2|Gene=Tb11.01.7800|UniProtKB=Q381H3	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00021	FGF signaling pathway	P00648	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00520	Rho GAPs	RAT|RGD=1307954|UniProtKB=Q5FVG6	Proline-rich protein 5	ISS			PTHR32428:SF4	PROLINE-RICH PROTEIN 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	90172230	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P06959	CCKR signaling map	P07085	RAF1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	RCA	10576742	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00463	betacatenin	MONDO|Ensembl=ENSMODG00000011192|UniProtKB=F6SRK5	Uncharacterized protein	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00018	EGF receptor signaling pathway	P00545	JNK1-3	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00162	Pro-BACE-1	MOUSE|MGI=MGI=1346542|UniProtKB=P56818	Beta-secretase 1	IDA	10956649	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	TAS	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05918	p38 MAPK pathway	P06037	TAK1	BOVIN|Ensembl=ENSBTAG00000002625|UniProtKB=A2VDU3	Mitogen-activated protein kinase kinase kinase 7	ISS	10683140	PubMed	PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00029	Huntington disease	P00796	Kainate receptor	TAKRU|Ensembl=ENSTRUG00000009259|UniProtKB=H2TF39	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00029	Huntington disease	P00796	Kainate receptor	RAT|RGD=2732|UniProtKB=P22756	Glutamate receptor ionotropic, kainate 1	IDA	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PANTR|Ensembl=ENSPTRG00000017675|UniProtKB=H2QS81	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P02747	Histidine biosynthesis	P02984	Imidazol glycerol phosphate dehydratase	LEPIN|EnsemblGenome=LA_0124|UniProtKB=Q8F9R6	Imidazoleglycerol-phosphate dehydratase	ISS			PTHR23133:SF2	IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE
P00025	Hedgehog signaling pathway	P00682	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00090	MDC9	HUMAN|HGNC=216|UniProtKB=Q13443	Disintegrin and metalloproteinase domain-containing protein 9	IDA	10510302	PubMed	PTHR11905:SF136	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 9
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	PANTR|Ensembl=ENSPTRG00000017238|UniProtKB=H2QRH7	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00001	Adrenaline and noradrenaline biosynthesis	P00061	PNMT	MACMU|Ensembl=ENSMMUG00000011760|UniProtKB=F7HSK5	Indolethylamine N-methyltransferase isoform 1	ISS			PTHR10867:SF6	INDOLETHYLAMINE N-METHYLTRANSFERASE-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	METJA|EnsemblGenome=MJ_0782|UniProtKB=Q58192	Transcription initiation factor IIB	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00021	FGF signaling pathway	P00627	ERK1-2	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01160	IP3 receptor	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MOUSE|MGI=MGI=97005|UniProtKB=P34960	Macrophage metalloelastase	TAS	12834808	PubMed	PTHR10201:SF32	MACROPHAGE METALLOELASTASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	PANTR|Ensembl=ENSPTRG00000012911|UniProtKB=H2QJE2	Uncharacterized protein	ISS	17943202	gi	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00019	Endothelin signaling pathway	P00590	IP3 R	CAEBR|Gene=CBG_05938|UniProtKB=H8WGV2	Protein CBR-ITR-1, isoform a	ISS	4262086	gi	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	CAEEL|WormBase=WBGene00004287|UniProtKB=Q94124	Ras-related protein rac-2	ISS	4757952	gi	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00047	PDGF signaling pathway	P01153	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00006	Apoptosis signaling pathway	P00272	ASK1	MACMU|Ensembl=ENSMMUG00000016376|UniProtKB=F7G2W1	Uncharacterized protein	ISS	12968034	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MOUSE|MGI=MGI=96647|UniProtKB=P09450	Transcription factor jun-B	TAS	10664585	PubMed	PTHR11462:SF37	TRANSCRIPTION FACTOR JUN-B
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000011898|UniProtKB=F7HN04	Uncharacterized protein	ISS	8120095	PubMed	PTHR43912:SF8	PROTOCADHERIN-7
P00036	Interleukin signaling pathway	P00990	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02771	Pyrimidine Metabolism	P03128	Dihydrouracil Dehydrogenase	MOUSE|MGI=MGI=2139667|UniProtKB=Q8CHR6	Dihydropyrimidine dehydrogenase [NADP(+)]	ISS	9819714	PubMed	PTHR43073:SF2	DIHYDROPYRIMIDINE DEHYDROGENASE  NADP +
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	XENTR|Xenbase=XB-GENE-481916|UniProtKB=F6YF14	Presenilin	ISS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00057	Wnt signaling pathway	P01438	PP2A	RAT|RGD=1585097|UniProtKB=A0A0G2JZD1	Protein Ppp2r5c	ISS	8576224	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P00021	FGF signaling pathway	P00625	MKK3,6	MONDO|Ensembl=ENSMODG00000006330|UniProtKB=F7AGV5	Uncharacterized protein	RCA			PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=1310389|UniProtKB=D3ZTF6	Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Predicted), isoform CRA_a	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00017	DNA replication	P00536	DNA Topisomerase	RAT|RGD=621246|UniProtKB=Q9WUL0	DNA topoisomerase 1	ISS			PTHR10290:SF5	DNA TOPOISOMERASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MOUSE|MGI=MGI=95821|UniProtKB=Q01097	Glutamate receptor ionotropic, NMDA 2B	IC	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00050	Plasminogen activating cascade	P01247	TAFI	HUMAN|HGNC=2300|UniProtKB=Q96IY4	Carboxypeptidase B2	IDA	92042093	PubMed	PTHR11705:SF17	CARBOXYPEPTIDASE B2
P00048	PI3 kinase pathway	P01199	Galpha	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	IC	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00034	Integrin signalling pathway	P00948	Rho	RAT|RGD=621309|UniProtKB=P62747	Rho-related GTP-binding protein RhoB	ISS	11973360	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00053	T cell activation	P01330	IKK	RAT|RGD=621375|UniProtKB=Q9QY78	Inhibitor of nuclear factor kappa-B kinase subunit beta	IGI	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	MOUSE|MGI=MGI=98180|UniProtKB=P07742	Ribonucleoside-diphosphate reductase large subunit	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00021	FGF signaling pathway	P00634	MEKK1-5	HUMAN|HGNC=6856|UniProtKB=Q9Y6R4	Mitogen-activated protein kinase kinase kinase 4	IGI	12052864	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00030	Hypoxia response via HIF activation	P00819	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P02728	Arginine biosynthesis	P02842	N-acetylornithine aminotransferase	AQUAE|EnsemblGenome=aq_023|UniProtKB=O66442	Acetylornithine aminotransferase	ISS	10074354	PubMed	PTHR11986:SF79	ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL
P00018	EGF receptor signaling pathway	P00543	ERK1-2	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	IGI	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00012	Cadherin signaling pathway	P00470	F-actin	RAT|RGD=628837|UniProtKB=P60711	Actin, cytoplasmic 1	IC	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00012	Cadherin signaling pathway	P00470	F-actin	PRIPA|Gene=PPA23459|UniProtKB=H3FMF2	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01198	FOXO	MACMU|Ensembl=ENSMMUG00000030780|UniProtKB=F6ZVZ0	Uncharacterized protein	ISS	10347145	PubMed	PTHR11829:SF159	FORKHEAD BOX PROTEIN O1
P04395	Vasopressin synthesis	P04593	Glycopeptide	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000002016|UniProtKB=F1P3G1	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00049	Parkinson disease	P01217	beta-Synuclein	PANTR|Ensembl=ENSPTRG00000017567|UniProtKB=H2QS30	Beta-synuclein	ISS	11683992	PubMed	PTHR13820:SF4	BETA-SYNUCLEIN
P00058	mRNA splicing	P01479	U1	HUMAN|HGNC=11151|UniProtKB=P09012	U1 small nuclear ribonucleoprotein A	RCA			PTHR10501:SF31	U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A
P00029	Huntington disease	P00780	Microtubule	DICPU|Gene=DICPUDRAFT_47166|UniProtKB=F0ZI20	Beta tubulin	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00021	FGF signaling pathway	P00645	Rac	DICDI|dictyBase=DDB_G0282365|UniProtKB=P34146	Rho-related protein rac1C	ISS	94124042	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00001	Adrenaline and noradrenaline biosynthesis	P00070	VAT2	BOVIN|Gene=SLC18A2|UniProtKB=Q27963	Synaptic vesicular amine transporter	ISS	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00037	Ionotropic glutamate receptor pathway	P01026	KA	HUMAN|HGNC=4581|UniProtKB=Q13003	Glutamate receptor ionotropic, kainate 3	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	MACMU|Ensembl=ENSMMUG00000003236|UniProtKB=F7DNS6	Uncharacterized protein	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00006	Apoptosis signaling pathway	P00291	MEKK1	MACMU|Ensembl=ENSMMUG00000012387|UniProtKB=F7EB20	Uncharacterized protein	ISS	12049732	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00005	Angiogenesis	P00255	Notch	HUMAN|HGNC=7881|UniProtKB=P46531	Neurogenic locus notch homolog protein 1	IDA	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P04398	p53 pathway feedback loops 2	P04651	Ras	MONDO|Ensembl=ENSMODG00000025248|UniProtKB=F7F5X1	Uncharacterized protein	ISS	99084794	PubMed	PTHR24070:SF186	GTPASE KRAS
P00030	Hypoxia response via HIF activation	P00823	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00034	Integrin signalling pathway	P00924	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	3449797	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00018	EGF receptor signaling pathway	P00543	ERK1-2	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00931	Integrin beta	HUMAN|HGNC=6162|UniProtKB=P26010	Integrin beta-7	IDA	3487386	PubMed	PTHR10082:SF36	INTEGRIN BETA-7
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000009626|UniProtKB=F6ZYQ0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00047	PDGF signaling pathway	P01160	IP3 receptor	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00036	Interleukin signaling pathway	P00985	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00015	Circadian clock system	P00505	Cry	ORNAN|Ensembl=ENSOANG00000005350|UniProtKB=F6X852	Uncharacterized protein	ISS	11804325	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00012	Cadherin signaling pathway	P00462	Casein kinase II	CAEBR|Gene=CBG12820|UniProtKB=A8XFP5	Protein CBR-KIN-3	ISS	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00021	FGF signaling pathway	P00625	MKK3,6	ANOGA|EnsemblGenome=AGAP000310|UniProtKB=Q7PRZ7	AGAP000310-PA	ISS			PTHR24361:SF645	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P00030	Hypoxia response via HIF activation	P00819	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	TAS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04552	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IDA	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	XENTR|Xenbase=XB-GENE-975313|UniProtKB=F7CSQ4	Uncharacterized protein	ISS	94365697	PubMed	PTHR11958:SF24	EXCITATORY AMINO ACID TRANSPORTER 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DROME|FlyBase=FBgn0000489|UniProtKB=P16912	Protein kinase DC2	IC	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04393	Ras Pathway	P04556	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	RAT|RGD=2871|UniProtKB=G3V824	Insulin-like growth factor 2 receptor, isoform CRA_b	ISS	11081635	PubMed	PTHR15071:SF17	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IC	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00047	PDGF signaling pathway	P01148	Grb2	XENTR|Xenbase=XB-GENE-6070000|UniProtKB=Q66II3	Growth factor receptor-bound protein 2	ISS	11384839	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00923	Arf1	CANLF|Ensembl=ENSCAFG00000006992|UniProtKB=E2RG67	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	TAS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	ORNAN|Ensembl=ENSOANG00000013961|UniProtKB=F6VPY1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	ORNAN|Ensembl=ENSOANG00000008907|UniProtKB=F7EDR2	Receptor protein serine/threonine kinase	ISS	10683140	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P00057	Wnt signaling pathway	P01465	Ggamma	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	CAEEL|WormBase=WBGene00000295|UniProtKB=Q9GNP0	Uncharacterized protein	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00642	MEK1-2	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00006	Apoptosis signaling pathway	P00310	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IDA	10799299	PubMed	PTHR10048:SF14	PI-3 KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00056	VEGF signaling pathway	P01412	HSP27	DANRE|ZFIN=ZDB-GENE-991119-2|UniProtKB=Q9PUR2	Alpha b crystallin	ISS			PTHR11527:SF37	ALPHA-CRYSTALLIN B CHAIN
P00029	Huntington disease	P00782	alpha-Adaptin	HUMAN|HGNC=561|UniProtKB=O95782	AP-2 complex subunit alpha-1	IDA	11532990	PubMed	PTHR22780:SF19	AP-2 COMPLEX SUBUNIT ALPHA-1
P00006	Apoptosis signaling pathway	P00260	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04558	p38	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	IDA	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MOUSE|MGI=MGI=104589|UniProtKB=P63268	Actin, gamma-enteric smooth muscle	IC	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00049	Parkinson disease	P01208	Hsp70	TAKRU|Ensembl=ENSTRUG00000002565|UniProtKB=H2S0M6	Uncharacterized protein	IDA	12150907	PubMed	PTHR19375:SF256	HSP70 PROTEIN-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05916	Opioid prodynorphin pathway	P06000	vasopressin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00021	FGF signaling pathway	P00631	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8051109	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00107	kinesin	HUMAN|HGNC=20717|UniProtKB=Q6P597	Kinesin light chain 3	IDA	11740561	PubMed	PTHR19959:SF125	KINESIN LIGHT CHAIN 3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00859	NFkappaB	PANTR|Ensembl=ENSPTRG00000011133|UniProtKB=H2QGK5	Uncharacterized protein	RCA			PTHR24169:SF18	TRANSCRIPTION FACTOR RELB
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00053	T cell activation	P01312	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IDA	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00036	Interleukin signaling pathway	P00976	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01087	CAT	CAEEL|WormBase=WBGene00000481|UniProtKB=P32756	Choline O-acetyltransferase	ISS	92155737	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00014	Cholesterol biosynthesis	P00491	Hydroxymethyl glutaryl CoA reductase	MACMU|Ensembl=ENSMMUG00000006139|UniProtKB=F6PRW7	3-hydroxy-3-methylglutaryl coenzyme A reductase	ISS	P00347	SPACC	PTHR10572:SF2	3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE
P00019	Endothelin signaling pathway	P00580	ET-RA/B	MACMU|Ensembl=ENSMMUG00000003659|UniProtKB=F7HSF3	Endothelin-1 receptor isoform a	ISS	8564193	PubMed	PTHR24243:SF31	ENDOTHELIN-1 RECEPTOR
P00047	PDGF signaling pathway	P01162	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00057	Wnt signaling pathway	P01440	Cadherin	DROME|FlyBase=FBgn0038247|UniProtKB=Q9VFH5	Cadherin 88C	ISS	8120095	PubMed	PTHR43956:SF8	CADHERIN 88C-RELATED
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	YEAST|SGD=S000004747|UniProtKB=P38615	Serine/threonine-protein kinase RIM11/MSD1	TAS			PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	LEIMA|EnsemblGenome=LmjF.32.2950|UniProtKB=Q9U1E1	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	MOUSE|MGI=MGI=96281|UniProtKB=P34968	5-hydroxytryptamine receptor 2C	ISS	12181435	PubMed	PTHR24247:SF32	5-HYDROXYTRYPTAMINE RECEPTOR 2C
P00036	Interleukin signaling pathway	P00965	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=13404|UniProtKB=Q9P2E7	Protocadherin-10	IDA	8120095	PubMed	PTHR24028:SF0	PROTOCADHERIN-10
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P06959	CCKR signaling map	P07019	RHOA-GDP	HUMAN|HGNC=667|UniProtKB=P61586	Transforming protein RhoA	RCA	19940064	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P02746	Heme biosynthesis	P02973	Uroporphyrinogen methyltransferase	YEAST|SGD=S000001777|UniProtKB=P36150	Uroporphyrinogen-III C-methyltransferase	ISS			PTHR21091:SF96	UROPORPHYRINOGEN-III C-METHYLTRANSFERASE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PANTR|Ensembl=ENSPTRG00000017939|UniProtKB=Q7JJU6	Tubulin beta chain	ISS	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00056	VEGF signaling pathway	P01408	Akt/PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	IDA	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00053	T cell activation	P01318	PKC-theta	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	METAC|EnsemblGenome=MA_4331|UniProtKB=Q8TI26	TATA-box-binding protein 1	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	BOVIN|Ensembl=ENSBTAG00000013099|UniProtKB=Q3ZBY4	Fructose-bisphosphate aldolase	ISS	3105602	PubMed	PTHR11627:SF3	FRUCTOSE-BISPHOSPHATE ALDOLASE C
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	RAT|RGD=3187|UniProtKB=Q07008	Neurogenic locus notch homolog protein 1	IDA	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00049	Parkinson disease	P01242	Casein kinase I	DAPPU|EnsemblGenome=DAPPUDRAFT_301140|UniProtKB=E9HGM4	Putative uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00057	Wnt signaling pathway	P01443	Phospholipase C	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00021	FGF signaling pathway	P00646	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	2842690	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00046	Oxidative stress response	P01134	cPLA2	CHICK|Ensembl=ENSGALG00000005065|UniProtKB=P49147	Cytosolic phospholipase A2	TAS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04398	p53 pathway feedback loops 2	P04649	Myc	CHICK|Ensembl=ENSGALG00000016308|UniProtKB=P01109	Myc proto-oncogene protein	TAS	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	BOVIN|Ensembl=ENSBTAG00000046248|UniProtKB=Q58CQ2	Actin-related protein 2/3 complex subunit 1B	ISS	12473693	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P06664	Gonadotropin-releasing hormone receptor pathway	P06841	gnaq/11	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	RCA	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00057	Wnt signaling pathway	P01453	Ebi	ANOGA|EnsemblGenome=AGAP007739|UniProtKB=Q7Q371	AGAP007739-PA	ISS	11389839	PubMed	PTHR22846:SF2	F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN TBL1X
P02774	Salvage pyrimidine deoxyribonucleotides	P03148	Thymidine phosphorylase	ECOLI|EcoGene=EG10219|UniProtKB=P07650	Thymidine phosphorylase	ISS	11206551	PubMed	PTHR10515:SF0	THYMIDINE PHOSPHORYLASE
P00018	EGF receptor signaling pathway	P00547	PP2A	PHYPA|Gene=PHYPADRAFT_206051|UniProtKB=A9RVI2	Serine/threonine-protein phosphatase	ISS			PTHR11668:SF24	SERINE/THREONINE-PROTEIN PHOSPHATASE 6 CATALYTIC SUBUNIT
P00021	FGF signaling pathway	P00633	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	PANTR|Ensembl=ENSPTRG00000007489|UniProtKB=H2QA49	Tyrosine-protein kinase receptor	ISS	11182407	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00036	Interleukin signaling pathway	P00996	STAT	MACMU|Ensembl=ENSMMUG00000010705|UniProtKB=F7G8V4	Signal transducer and activator of transcription	ISS	8584036	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	STRCO|EnsemblGenome=CAB42016|UniProtKB=Q9X8P6	Adenylosuccinate synthetase	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00052	TGF-beta signaling pathway	P01286	TGFbeta	RAT|RGD=1585858|UniProtKB=D3ZTI5	Protein Bmp8a	ISS	9759503	PubMed	PTHR11848:SF119	BONE MORPHOGENETIC PROTEIN 8A
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00011	Blood coagulation	P00458	GP IIIa	MACMU|Ensembl=ENSMMUG00000003289|UniProtKB=F7FG54	Integrin beta	ISS	20069419	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00017	DNA replication	P00527	Histones	CRYNJ|EnsemblGenome=CNB00570|UniProtKB=Q5KMT3	Histone H3	ISS	20448842	PubMed	PTHR11426:SF47	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00945	Parvin	MACMU|Ensembl=ENSMMUG00000015448|UniProtKB=F6QBC8	Uncharacterized protein	ISS	11331308	PubMed	PTHR12114:SF7	BETA-PARVIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	MONDO|Ensembl=ENSMODG00000024440|UniProtKB=F7DJJ2	Muscarinic acetylcholine receptor	ISS	11166329	PubMed	PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00047	PDGF signaling pathway	P01174	Rho	RAT|RGD=1303143|UniProtKB=Q6AYD8	Protein Arhgap8	ISS			PTHR23176:SF3	PROTEIN PRR5-ARHGAP8-RELATED
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	HUMAN|HGNC=4383|UniProtKB=P30679	Guanine nucleotide-binding protein subunit alpha-15	IDA	11534853	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00965	ERK	BOVIN|Ensembl=ENSBTAG00000001014|UniProtKB=A5PKJ4	Mitogen-activated protein kinase 7	ISS	15085193	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	RAT|RGD=3187|UniProtKB=Q07008	Neurogenic locus notch homolog protein 1	IDA	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00019	Endothelin signaling pathway	P00590	IP3 R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	MACMU|Ensembl=ENSMMUG00000013047|UniProtKB=F7H808	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00054	Toll receptor signaling pathway	P01369	MKK1	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06739	MEK1/2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	RCA	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00543	ERK1-2	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00051	TCA cycle	P01267	Citrate Synthase	RAT|RGD=620330|UniProtKB=Q8VHF5	Citrate synthase, mitochondrial	RCA			PTHR11739:SF8	CITRATE SYNTHASE, MITOCHONDRIAL
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00011	Blood coagulation	P00418	Fibrin monomer	PANTR|Ensembl=ENSPTRG00000016534|UniProtKB=H2QQB4	Uncharacterized protein	ISS	6575700	PubMed	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	ARATH|TAIR=AT3G47290|UniProtKB=Q9STZ3	Phosphoinositide phospholipase C 8	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00049	Parkinson disease	P01238	14-3-3	HUMAN|HGNC=12854|UniProtKB=P27348	14-3-3 protein theta	IDA	5803227	gi	PTHR18860:SF3	14-3-3 PROTEIN THETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=619741|UniProtKB=F1LR98	Protein Cdh10	ISS	8120095	PubMed	PTHR24027:SF290	CADHERIN-10
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	ARATH|TAIR=AT5G47080|UniProtKB=P40228	Casein kinase II subunit beta	IDA	10806215	PubMed	PTHR11740:SF15	CASEIN KINASE II SUBUNIT BETA-RELATED
P05730	Endogenous cannabinoid signaling	P05746	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	HUMAN|HGNC=307|UniProtKB=Q08117	Amino-terminal enhancer of split	IDA	9783586	PubMed	PTHR10814:SF4	AMINO-TERMINAL ENHANCER OF SPLIT-RELATED
P00047	PDGF signaling pathway	P01173	STAT	MOUSE|MGI=MGI=103062|UniProtKB=P42228	Signal transducer and activator of transcription 4	ISS	94255416	PubMed	PTHR11801:SF19	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 4
P00005	Angiogenesis	P00219	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P02738	De novo purine biosynthesis	P02889	dGDP kinase	METJA|EnsemblGenome=MJ_1265|UniProtKB=Q58661	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02741	Flavin biosynthesis	P02936	FAD synthetase	ECOLI|EcoGene=EG11079|UniProtKB=P0AG40	Riboflavin biosynthesis protein RibF	RCA			PTHR22749:SF2	RIBOFLAVIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	11313908	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04393	Ras Pathway	P04547	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	ISS	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00036	Interleukin signaling pathway	P00973	PKB	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00634	MEKK1-5	MACMU|Ensembl=ENSMMUG00000012387|UniProtKB=F7EB20	Uncharacterized protein	ISS	8643568	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00010	B cell activation	P00383	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IDA	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	G01535	PIG3	CANLF|Ensembl=ENSCAFG00000003963|UniProtKB=E2RR83	Uncharacterized protein	ISS	12932731	PubMed	PTHR43006:SF2	QUINONE OXIDOREDUCTASE PIG3
P05731	GABA-B receptor II signaling	P05755	Gbeta	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	RAT|RGD=628852|UniProtKB=Q02294	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	11976940	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00018	EGF receptor signaling pathway	P00545	JNK1-3	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	TAS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=1953|UniProtKB=P08173	Muscarinic acetylcholine receptor M4	IDA	10069496	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000001114|UniProtKB=E1B7L9	Serine/threonine-protein kinase	ISS	12676944	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	CRYNJ|EnsemblGenome=CND03830|UniProtKB=Q5KI86	Uncharacterized protein	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MONDO|Ensembl=ENSMODG00000008920|UniProtKB=F7GL76	Uncharacterized protein	ISS			PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00780	Microtubule	CAEEL|WormBase=WBGene00003171|UniProtKB=P12456	Tubulin beta-1 chain	IDA	9454836	PubMed	PTHR11588:SF255	TUBA7L PROTEIN
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=18539|UniProtKB=P61266	Syntaxin-1B	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	ISS	11535291	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00034	Integrin signalling pathway	P00925	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MONDO|Ensembl=ENSMODG00000001807|UniProtKB=F6Y7R9	Uncharacterized protein	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P04379	Beta3 adrenergic receptor signaling pathway	P04449	Beta3	MOUSE|MGI=MGI=87939|UniProtKB=P25962	Beta-3 adrenergic receptor	ISS	11943840	PubMed	PTHR24248:SF3	BETA-3 ADRENERGIC RECEPTOR
P00021	FGF signaling pathway	P00624	14-3-3	MOUSE|MGI=MGI=1891917|UniProtKB=Q9CQV8	14-3-3 protein beta/alpha	ISS	1671102	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00012	Cadherin signaling pathway	P00466	EGFR	PANTR|Ensembl=ENSPTRG00000012883|UniProtKB=H2QJC5	Receptor protein-tyrosine kinase	ISS	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00034	Integrin signalling pathway	P00944	Actin	MONDO|Ensembl=ENSMODG00000012036|UniProtKB=F7ALP1	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00591	PLCbeta	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IDA	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00012	Cadherin signaling pathway	P00474	Wnt	CANLF|Ensembl=ENSCAFG00000029321|UniProtKB=J9P5H0	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	RAT|RGD=619858|UniProtKB=P70579	Metabotropic glutamate receptor 8	IC	12351712	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P02783	Tryptophan biosynthesis	P03206	Anthranilate synthase	PYRAE|EnsemblGenome=PAE2460|UniProtKB=Q8ZV46	Anthranilate synthase component I	ISS			PTHR11236:SF9	ANTHRANILATE SYNTHASE COMPONENT 1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00008	Axon guidance mediated by Slit/Robo	P00342	Slit	CANLF|Ensembl=ENSCAFG00000008945|UniProtKB=F1PSS7	Uncharacterized protein	ISS	10102268	PubMed	PTHR24373:SF39	SLIT HOMOLOG 1 PROTEIN
P00020	FAS signaling pathway	P00615	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	DANRE|ZFIN=ZDB-GENE-050417-59|UniProtKB=Q15KE4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01407	Erk	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00018	EGF receptor signaling pathway	P00551	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02763	Peptidoglycan biosynthesis	P03083	UDP-N-acetylmuramoylalanine-D-glutamate ligase	DEIRA|EnsemblGenome=DR_2496|UniProtKB=Q9RRJ4	UDP-N-acetylmuramoylalanine--D-glutamate ligase	ISS			PTHR43692:SF1	UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE
P00014	Cholesterol biosynthesis	P00491	Hydroxymethyl glutaryl CoA reductase	CANLF|Ensembl=ENSCAFG00000009517|UniProtKB=E2R9Z3	3-hydroxy-3-methylglutaryl coenzyme A reductase	ISS	P00347	SPACC	PTHR10572:SF2	3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00052	TGF-beta signaling pathway	P01292	RSmads	TAKRU|Ensembl=ENSTRUG00000015216|UniProtKB=H2UPJ8	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF42	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00059	p53 pathway	P04633	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00623	FGF	CHICK|Ensembl=ENSGALG00000002203|UniProtKB=F6RRS5	Fibroblast growth factor	IGI	20368156	PubMed	PTHR11486:SF4	FIBROBLAST GROWTH FACTOR 18
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	NAS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04393	Ras Pathway	P04567	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00058	mRNA splicing	P01474	U5	HUMAN|HGNC=30857|UniProtKB=Q96DI7	U5 small nuclear ribonucleoprotein 40 kDa protein	IGI	9774689	PubMed	PTHR44006:SF1	U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	SCLS1|EnsemblGenome=SS1G_03482|UniProtKB=A7EDU2	Guanine nucleotide-binding protein beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00054	Toll receptor signaling pathway	P01375	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	XENTR|Xenbase=XB-GENE-944729|UniProtKB=Q6GL72	Dihydropyrimidinase-related protein 3	ISS	3122041	gi	PTHR11647:SF57	DIHYDROPYRIMIDINASE-RELATED PROTEIN 3
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00310	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	14744428	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00057	Wnt signaling pathway	P01444	Wnt	RAT|RGD=69079|UniProtKB=M0R9D3	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P06587	Nicotine pharmacodynamics pathway	P06590	GNG	BOVIN|Ensembl=ENSBTAG00000003043|UniProtKB=P63212	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00015	Circadian clock system	G01503	per	MACMU|Ensembl=ENSMMUG00000021798|UniProtKB=F7ESU2	Uncharacterized protein	ISS	20570170	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00057	Wnt signaling pathway	P01471	alpha-catenin	MONDO|Ensembl=ENSMODG00000015456|UniProtKB=F6S406	Uncharacterized protein	ISS	9362521	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00059	p53 pathway	P01485	p53	DANRE|ZFIN=ZDB-GENE-030819-1|UniProtKB=E9QG65	Uncharacterized protein	TAS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	HUMAN|HGNC=5295|UniProtKB=P28335	5-hydroxytryptamine receptor 2C	ISS	8143856	PubMed	PTHR24247:SF32	5-HYDROXYTRYPTAMINE RECEPTOR 2C
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	CHICK|Ensembl=ENSGALG00000011558|UniProtKB=F1NWV6	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01211	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P06210	Activin beta signaling pathway	P06235	SARA	DROME|FlyBase=FBgn0026369|UniProtKB=Q7K9H6	FI05490p	IEA	12040180	PubMed	PTHR22835:SF299	FI05490P
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P02721	ATP synthesis	P02796	F1 gamma	MOUSE|MGI=MGI=1261437|UniProtKB=Q91VR2	ATP synthase subunit gamma, mitochondrial	ISS	9736690	PubMed	PTHR11693:SF22	ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL
P00018	EGF receptor signaling pathway	P00561	STAT	BOVIN|Gene=STAT5A|UniProtKB=Q95115	Signal transducer and activator of transcription 5A	ISS	14662325	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00048	PI3 kinase pathway	P01181	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00004	Alzheimer disease-presenilin pathway	P00126	Fe65	BOVIN|Ensembl=ENSBTAG00000015655|UniProtKB=Q17QV1	Amyloid beta (A4) protein-binding, family B, member 1 (Fe65)	ISS	15115822	PubMed	PTHR14058:SF5	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	CHICK|Ensembl=ENSGALG00000010273|UniProtKB=P48463	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	1662645	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00029	Huntington disease	P00778	NMDA receptor	MOUSE|MGI=MGI=95819|UniProtKB=P35438	Glutamate receptor ionotropic, NMDA 1	IDA	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MACMU|Ensembl=ENSMMUG00000023290|UniProtKB=F6ZBU9	Uncharacterized protein	ISS	10844590	PubMed	PTHR11848:SF151	EMBRYONIC GROWTH/DIFFERENTIATION FACTOR 1
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=1261834|UniProtKB=O70283	Protein Wnt-2b	IDA	8717036	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00047	PDGF signaling pathway	P01173	STAT	HUMAN|HGNC=11362|UniProtKB=P42224	Signal transducer and activator of transcription 1-alpha/beta	ISS	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01435	SWI/SNF	MONDO|Ensembl=ENSMODG00000000184|UniProtKB=F6TFW8	Uncharacterized protein	ISS	11532957	PubMed	PTHR10799:SF868	DNA HELICASE INO80
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00632	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	XENTR|Xenbase=XB-GENE-961764|UniProtKB=F6W3Y0	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	HUMAN|HGNC=4597|UniProtKB=P41594	Metabotropic glutamate receptor 5	IDA	92317054	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	PANTR|Ensembl=ENSPTRG00000019361|UniProtKB=H2QUV3	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	PANTR|Ensembl=ENSPTRG00000013902|UniProtKB=H2RCL0	Uncharacterized protein	ISS	2433589	PubMed	PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P00056	VEGF signaling pathway	P01409	cPLA2	BOVIN|Ensembl=ENSBTAG00000013298|UniProtKB=A4IFJ5	Cytosolic phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00034	Integrin signalling pathway	P00927	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	8649368	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00057	Wnt signaling pathway	P01457	GBeta	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IDA	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00023	General transcription regulation	P00662	TFIIA complex	CHICK|Ensembl=ENSGALG00000010576|UniProtKB=F1NKT1	Uncharacterized protein	ISS	600519	OMIM	PTHR12694:SF7	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1
P00018	EGF receptor signaling pathway	P00539	14-3-3	MOUSE|MGI=MGI=894689|UniProtKB=P62259	14-3-3 protein epsilon	ISS	9450960	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04393	Ras Pathway	P04552	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00029	Huntington disease	P00778	NMDA receptor	BOVIN|Ensembl=ENSBTAG00000000219|UniProtKB=F1MCL3	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00012	Cadherin signaling pathway	P00470	F-actin	MOUSE|MGI=MGI=87905|UniProtKB=P68033	Actin, alpha cardiac muscle 1	IC	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00049	Parkinson disease	P01219	SAPK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	BOVIN|Ensembl=ENSBTAG00000000219|UniProtKB=F1MCL3	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00019	Endothelin signaling pathway	P00590	IP3 R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00006	Apoptosis signaling pathway	P00260	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	ARATH|TAIR=AT2G23080|UniProtKB=O64817	Probable casein kinase II subunit alpha	IDA	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P02781	Threonine biosynthesis	P03190	Threonine synthase	HALSA|EnsemblGenome=VNG_2430G|UniProtKB=Q9HMQ7	Threonine synthase	ISS			PTHR10314:SF5	THREONINE SYNTHASE 1, CHLOROPLASTIC
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=107711|UniProtKB=P70248	Unconventional myosin-If	IC			PTHR13140:SF288	UNCONVENTIONAL MYOSIN-IF
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	XENTR|Xenbase=XB-GENE-481559|UniProtKB=F6SRT1	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF165	COLLAGENASE 3
P00049	Parkinson disease	P01235	Fyn kinase	MONDO|Ensembl=ENSMODG00000017905|UniProtKB=F7FG65	Tyrosine-protein kinase	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00048	PI3 kinase pathway	P01199	Galpha	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	CHICK|Ensembl=ENSGALG00000006552|UniProtKB=P67970	Insulin	ISS			PTHR11454:SF9	INSULIN-RELATED
P00006	Apoptosis signaling pathway	P00325	Bim	MOUSE|MGI=MGI=1197519|UniProtKB=O54918	Bcl-2-like protein 11	ISS	11859372	PubMed	PTHR12044:SF9	BCL-2-LIKE PROTEIN 11
P00010	B cell activation	P00397	IKK	HUMAN|HGNC=5960|UniProtKB=O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	IGI	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00053	T cell activation	P01300	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	RAT|RGD=3188|UniProtKB=Q9QW30	Neurogenic locus notch homolog protein 2	IDA	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00019	Endothelin signaling pathway	P00589	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01425	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	CHICK|Ensembl=ENSGALG00000010319|UniProtKB=P47191	Synaptotagmin-1	RCA			PTHR10024:SF239	SYNAPTOTAGMIN-1
P00057	Wnt signaling pathway	P01447	Dishevelled	MOUSE|MGI=MGI=108100|UniProtKB=Q61062	Segment polarity protein dishevelled homolog DVL-3	ISS	10409711	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	10514528	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00056	VEGF signaling pathway	P01407	Erk	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04395	Vasopressin synthesis	P04597	Signal Peptide	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MOUSE|MGI=MGI=1927469|UniProtKB=Q9QZB0	Regulator of G-protein signaling 17	IDA	8756726	PubMed	PTHR10845:SF196	REGULATOR OF G-PROTEIN SIGNALING 17
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00057	Wnt signaling pathway	P01457	GBeta	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00547	PP2A	MOUSE|MGI=MGI=1321161|UniProtKB=P62715	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00056	VEGF signaling pathway	P01417	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	CHICK|Gene_ORFName=RCJMB04_24e7|UniProtKB=P62149	Calmodulin	ISS	3885394	PubMed	PTHR23050:SF311	CALMODULIN
P06664	Gonadotropin-releasing hormone receptor pathway	G06899	COX2	MOUSE|MGI=MGI=102503|UniProtKB=P00405	Cytochrome c oxidase subunit 2	RCA			PTHR22888:SF9	CYTOCHROME C OXIDASE SUBUNIT 2
P00057	Wnt signaling pathway	P01457	GBeta	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	CANLF|Ensembl=ENSCAFG00000016387|UniProtKB=E2QV83	Uncharacterized protein	ISS	15187023	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00525	N-WASP	CANLF|Ensembl=ENSCAFG00000001771|UniProtKB=E2RCG1	Uncharacterized protein	ISS	12932731	PubMed	PTHR23202:SF39	NEURAL WISKOTT-ALDRICH SYNDROME PROTEIN
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	HUMAN|HGNC=10628|UniProtKB=P16619	C-C motif chemokine 3-like 1	ISS			PTHR12015:SF91	C-C MOTIF CHEMOKINE 3-RELATED
P02746	Heme biosynthesis	P02973	Uroporphyrinogen methyltransferase	NEUCR|EnsemblGenome=EFNCRG00000000890|UniProtKB=Q7SI49	Siroheme synthase	ISS			PTHR21091:SF96	UROPORPHYRINOGEN-III C-METHYLTRANSFERASE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=12783|UniProtKB=P56705	Protein Wnt-4	TAS	11266476	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00021	FGF signaling pathway	P00643	Raf-1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IGI	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MACMU|Ensembl=ENSMMUG00000010266|UniProtKB=F6PV18	Uncharacterized protein	ISS	14500986	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00017	DNA replication	P00534	PCNA	CANLF|Ensembl=ENSCAFG00000006030|UniProtKB=E2R0D6	Proliferating cell nuclear antigen	ISS	12893285	PubMed	PTHR11352:SF0	PROLIFERATING CELL NUCLEAR ANTIGEN
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	MOUSE|MGI=MGI=1346037|UniProtKB=Q9WTL4	Insulin receptor-related protein	ISS	11182407	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	IPI	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00591	PLCbeta	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	DANRE|ZFIN=ZDB-GENE-000330-9|UniProtKB=Q90ZE4	Presenilin-2	IDA	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00006	Apoptosis signaling pathway	P00277	Bi1	CANLF|Ensembl=ENSCAFG00000008400|UniProtKB=E2QY18	Uncharacterized protein	ISS			PTHR23291:SF34	BAX INHIBITOR 1
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02738	De novo purine biosynthesis	P02891	GDP kinase	PANTR|Ensembl=ENSPTRG00000007605|UniProtKB=H2QAA6	Nucleoside diphosphate kinase	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	LEIMA|EnsemblGenome=LmjF.32.2950|UniProtKB=Q9U1E1	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00034	Integrin signalling pathway	P00924	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05953	EPB41L1	BOVIN|Ensembl=ENSBTAG00000001640|UniProtKB=F1N611	Uncharacterized protein	ISS	12181426	PubMed	PTHR23280:SF24	BAND 4.1-LIKE PROTEIN 1
P00018	EGF receptor signaling pathway	P00551	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	IGI	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00990	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00034	Integrin signalling pathway	P00944	Actin	MACMU|Ensembl=ENSMMUG00000001353|UniProtKB=F7D6T8	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	CANLF|Ensembl=ENSCAFG00000010476|UniProtKB=F1PS94	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04393	Ras Pathway	P04572	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00036	Interleukin signaling pathway	P00983	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00011	Blood coagulation	P00434	FXIa	RAT|RGD=1309364|UniProtKB=A0A0G2K4I9	Protein F11	ISS	13811665	gi	PTHR44459:SF1	COAGULATION FACTOR XI
P00010	B cell activation	P00371	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	RCA	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00006	Apoptosis signaling pathway	P00298	Caspase 9	PANTR|Ensembl=ENSPTRG00000000200|UniProtKB=H2PY35	Caspase	ISS	11440972	PubMed	PTHR10454:SF157	CASPASE-9
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00007	Axon guidance mediated by semaphorins	P00340	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	8649368	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04393	Ras Pathway	P04542	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P06209	ALP23B signaling pathway	P06227	FUR1	DROME|FlyBase=FBgn0004509|UniProtKB=P26016	Furin-like protease 1, isoforms 1/1-X/2	IEA	7737999	PubMed	PTHR42884:SF3	FURIN-LIKE PROTEASE 1, ISOFORMS 1/1-X/2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MOUSE|MGI=MGI=96274|UniProtKB=P28334	5-hydroxytryptamine receptor 1B	ISS	12441358	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P00025	Hedgehog signaling pathway	P00682	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00807	Actin	CAEEL|WormBase=WBGene00000064|UniProtKB=P10984	Actin-2	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00005	Angiogenesis	P00186	FGFR-1	HUMAN|HGNC=3688|UniProtKB=P11362	Fibroblast growth factor receptor 1	IDA	9989949	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-8225|UniProtKB=Q7SZZ5	Uncharacterized protein	ISS			PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	RAT|RGD=2733|UniProtKB=P42260	Glutamate receptor ionotropic, kainate 2	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00029	Huntington disease	P00774	Dynein complex	DROME|FlyBase=FBgn0013813|UniProtKB=Q9VAV5	Dynein heavy chain at 89D, isoform B	IPI	9454836	PubMed	PTHR10676:SF343	DYNEIN HEAVY CHAIN 10, AXONEMAL
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CANLF|Ensembl=ENSCAFG00000004930|UniProtKB=E2RFB5	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	ANOGA|EnsemblGenome=AGAP011840|UniProtKB=Q7PZC6	AGAP011840-PA (Fragment)	ISS	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00054	Toll receptor signaling pathway	P01375	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00021	FGF signaling pathway	P00642	MEK1-2	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00019	Endothelin signaling pathway	P00591	PLCbeta	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	BOVIN|Ensembl=ENSBTAG00000024507|UniProtKB=E1BNF2	Uncharacterized protein	ISS			PTHR11767:SF17	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 3
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MOUSE|MGI=MGI=95821|UniProtKB=Q01097	Glutamate receptor ionotropic, NMDA 2B	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00044	Nicotinic acetylcholine receptor signaling pathway	P01095	beta	RAT|RGD=2350|UniProtKB=P12390	Neuronal acetylcholine receptor subunit beta-2	ISS	22213672	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CAEBR|Gene=CBG02401|UniProtKB=A8WUE7	Protein CBR-NMR-1	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	9298898	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00020	FAS signaling pathway	P00611	Gelsolin	CANLF|Ensembl=ENSCAFG00000003663|UniProtKB=F6Y3P9	Uncharacterized protein	ISS	9323209	PubMed	PTHR11977:SF29	GELSOLIN
P00053	T cell activation	P01321	SLP-76	MACMU|Ensembl=ENSMMUG00000014126|UniProtKB=F7C1G6	Uncharacterized protein	ISS	9665884	PubMed	PTHR14098:SF1	LYMPHOCYTE CYTOSOLIC PROTEIN 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05941	GRK3	DANRE|ZFIN=ZDB-GENE-030616-382|UniProtKB=B5LZ08	Protein-serine/threonine kinase	ISS	10852916	PubMed	PTHR24355:SF18	PROTEIN-SERINE/THREONINE KINASE
P00019	Endothelin signaling pathway	P00570	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00010	B cell activation	P00391	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	TAS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00012	Cadherin signaling pathway	P00462	Casein kinase II	DROME|FlyBase=FBgn0264492|UniProtKB=P08181	Casein kinase II subunit alpha	ISS	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01433	SIAH-1	BOVIN|Ensembl=ENSBTAG00000023445|UniProtKB=F1MBM6	E3 ubiquitin-protein ligase	ISS			PTHR10315:SF11	E3 UBIQUITIN-PROTEIN LIGASE SIAH2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	MOUSE|MGI=MGI=98261|UniProtKB=P14097	C-C motif chemokine 4	IDA	12393677	PubMed	PTHR12015:SF145	C-C MOTIF CHEMOKINE 4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	MACMU|Ensembl=ENSMMUG00000001661|UniProtKB=F7GR69	Uncharacterized protein	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00020	FAS signaling pathway	P00615	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01167	Ets	BOVIN|Ensembl=ENSBTAG00000002341|UniProtKB=A5PJG9	ETS1 protein	ISS	15699632	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P04393	Ras Pathway	P04567	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IDA	10799299	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DANRE|ZFIN=ZDB-GENE-040426-2427|UniProtKB=F1Q6C0	Uncharacterized protein (Fragment)	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00029	Huntington disease	P00805	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00049	Parkinson disease	P01227	20S proteasome	RAT|RGD=61875|UniProtKB=P40112	Proteasome subunit beta type-3	ISS	12859888	PubMed	PTHR11599:SF62	PROTEASOME SUBUNIT BETA TYPE-3
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8664|UniProtKB=Q9Y5I2	Protocadherin alpha-10	IDA	8120095	PubMed	PTHR24028:SF124	PROTOCADHERIN ALPHA-10
P00010	B cell activation	P00398	IP3R	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PUCGT|EnsemblGenome=PGTG_05488|UniProtKB=E3K4I1	Actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05918	p38 MAPK pathway	P06031	p38alpha	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	RCA	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04393	Ras Pathway	P04558	p38	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	HUMAN|HGNC=4383|UniProtKB=P30679	Guanine nucleotide-binding protein subunit alpha-15	IC	11359849	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12701063	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00007	Axon guidance mediated by semaphorins	P00328	plexinB1	PANTR|Ensembl=ENSPTRG00000014884|UniProtKB=H2QMJ0	Plexin B1	ISS			PTHR22625:SF36	PLEXIN-B1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MOUSE|MGI=MGI=109246|UniProtKB=P97288	5-hydroxytryptamine receptor 4	IDA	15118808	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P04386	Histamine H2 receptor mediated signaling pathway	P04489	H2	HUMAN|HGNC=5183|UniProtKB=P25021	Histamine H2 receptor	ISS	11841575	PubMed	PTHR43893:SF5	HISTAMINE H2 RECEPTOR
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00018	EGF receptor signaling pathway	P00552	Ras	MONDO|Gene=KRAS|UniProtKB=Q07983	GTPase KRas	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00029	Huntington disease	P00807	Actin	ANOGA|EnsemblGenome=AGAP001676|UniProtKB=Q7PXZ8	AGAP001676-PA	IDA	11889126	PubMed	PTHR11937:SF368	ACTIN, INDIRECT FLIGHT MUSCLE
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	CANAL|CGD=CAL0000189123|UniProtKB=O13426	Serine hydroxymethyltransferase, cytosolic	ISS			PTHR11680:SF25	SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IPI	7937853	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00256	PLC-gamma	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00013	Cell cycle	P00483	Cyclin E	DANRE|ZFIN=ZDB-GENE-980526-168|UniProtKB=P47794	G1/S-specific cyclin-E1	NAS	12628165	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00047	PDGF signaling pathway	P01174	Rho	CANLF|Ensembl=ENSCAFG00000005473|UniProtKB=E2RAB4	Uncharacterized protein	ISS	8288572	PubMed	PTHR23181:SF5	RHO GTPASE-ACTIVATING PROTEIN 15
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00055	Transcription regulation by bZIP transcription factor	P01392	TFIIH complex	RAT|RGD=1308225|UniProtKB=A0A0G2JWQ0	Protein Gtf2h1	ISS			PTHR12856:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 1
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00060	Ubiquitin proteasome pathway	P01491	E2	RAT|RGD=708345|UniProtKB=P63149	Ubiquitin-conjugating enzyme E2 B	ISS			PTHR43898:SF6	UBIQUITIN-CONJUGATING ENZYME E2 B
P04393	Ras Pathway	P04566	Stat 1/3	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01174	Rho	DANRE|ZFIN=ZDB-GENE-041210-103|UniProtKB=B7ZVG9	Si:ch211-125a15.2 protein	ISS	8288572	PubMed	PTHR14166:SF15	SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 1
P05730	Endogenous cannabinoid signaling	P05746	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06834	MAP3Ks	MOUSE|MGI=MGI=2449952|UniProtKB=Q3U1V8	Mitogen-activated protein kinase kinase kinase 9	RCA			PTHR43997:SF2	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 9
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	DROME|FlyBase=FBgn0010341|UniProtKB=P40793	Cdc42 homolog	ISS	4757952	gi	PTHR24072:SF192	CDC42 HOMOLOG
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02738	De novo purine biosynthesis	P02904	Guanylate kinase	BACSU|EnsemblGenome=BSU15680|UniProtKB=O34328	Guanylate kinase	ISS			PTHR23117:SF13	GUANYLATE KINASE
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00048	PI3 kinase pathway	P01192	p110	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	BOVIN|Ensembl=ENSBTAG00000011339|UniProtKB=A7MAZ4	Transcription initiation factor TFIID subunit 8	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00936	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00047	PDGF signaling pathway	P01173	STAT	HUMAN|HGNC=11363|UniProtKB=P52630	Signal transducer and activator of transcription 2	ISS			PTHR11801:SF41	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 2
P00036	Interleukin signaling pathway	P00990	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00909	ASAP1	RAT|RGD=1307379|UniProtKB=Q1AAU6	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1	RCA			PTHR23180:SF192	ARF-GAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1
P00050	Plasminogen activating cascade	P01245	PAI-1	MOUSE|MGI=MGI=97608|UniProtKB=P22777	Plasminogen activator inhibitor 1	ISS	6981332	gi	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00048	PI3 kinase pathway	P01188	Gbetagamma	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00010	B cell activation	P00373	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IGI	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05913	Enkephalin release	P05971	CREB	MOUSE|MGI=MGI=88494|UniProtKB=Q01147	Cyclic AMP-responsive element-binding protein 1	ISS	11752053	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00029	Huntington disease	P00805	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01292	RSmads	HUMAN|HGNC=6768|UniProtKB=Q15796	Mothers against decapentaplegic homolog 2	TAS	9395284	PubMed	PTHR13703:SF42	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00006	Apoptosis signaling pathway	P00274	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00775	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12932731	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00054	Toll receptor signaling pathway	P01352	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04560	AP1	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	12846562	PubMed	PTHR10202:SF13	PRESENILIN-2
P06664	Gonadotropin-releasing hormone receptor pathway	P06850	PKCs(3)	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=17999|UniProtKB=Q6P5Z2	Serine/threonine-protein kinase N3	IC	10644715	PubMed	PTHR24356:SF175	SERINE/THREONINE-PROTEIN KINASE N3
P02738	De novo purine biosynthesis	P02909	GDP reductase	MOUSE|MGI=MGI=98181|UniProtKB=P11157	Ribonucleoside-diphosphate reductase subunit M2	ISS			PTHR23409:SF20	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05915	Opioid proenkephalin pathway	P05994	G-protein	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95816|UniProtKB=B1AS29	Glutamate receptor ionotropic, kainate 3	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00059	p53 pathway	G01580	p21	MACMU|Ensembl=ENSMMUG00000003210|UniProtKB=F7EEK4	Cyclin-dependent kinase inhibitor 1	ISS			PTHR10265:SF16	CYCLIN-DEPENDENT KINASE INHIBITOR 1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	TAS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00589	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IGI	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	CHICK|Ensembl=ENSGALG00000002447|UniProtKB=E1C7M7	Uncharacterized protein	ISS	10456847	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00059	p53 pathway	P04634	Cdc2	CANLF|Ensembl=ENSCAFG00000000082|UniProtKB=E2QW70	Uncharacterized protein	ISS	15660127	PubMed	PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MACMU|Ensembl=ENSMMUG00000001820|UniProtKB=F7AG67	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF27	REGULATOR OF G-PROTEIN SIGNALING 6
P05731	GABA-B receptor II signaling	P05754	Ggamma	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	RCA	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	ARATH|TAIR=AT4G34460|UniProtKB=P49177	Guanine nucleotide-binding protein subunit beta	ISS	11313908	PubMed	PTHR19850:SF48	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA
P00056	VEGF signaling pathway	P01425	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	10747026	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DANRE|ZFIN=ZDB-GENE-040426-2427|UniProtKB=F1Q6C0	Uncharacterized protein (Fragment)	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00543	ERK1-2	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	IGI	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8972|UniProtKB=O00750	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P02731	Biotin biosynthesis	P02857	Biotin synthase	ARATH|TAIR=AT2G43360|UniProtKB=P54967	Biotin synthase	ISS			PTHR22976:SF1	BIOTIN SYNTHASE, MITOCHONDRIAL
P00021	FGF signaling pathway	P00648	PKC	CANAL|CGD=CAL0003231|UniProtKB=Q5ANK2	Protein kinase C	IGI	11554554	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00015	Circadian clock system	P00502	Casein kinase I	DROME|FlyBase=FBgn0002413|UniProtKB=O76324	Discs overgrown protein kinase	IDA	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000012036|UniProtKB=F7ALP1	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00056	VEGF signaling pathway	P01415	MAPKAPK2/3	MACMU|Ensembl=ENSMMUG00000010495|UniProtKB=F7BFL2	MAP kinase-activated protein kinase 3	ISS	11335727	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P00048	PI3 kinase pathway	P01199	Galpha	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	IC	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DANRE|ZFIN=ZDB-GENE-041210-195|UniProtKB=F1R506	Protein kinase C	ISS	11880265	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	DROME|FlyBase=FBgn0010287|UniProtKB=Q27896	TBP-related factor	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05972	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00055	Transcription regulation by bZIP transcription factor	P01395	TFIIE	MACMU|Ensembl=ENSMMUG00000001596|UniProtKB=F7GV34	General transcription factor IIE subunit 1	ISS	189964	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00048	PI3 kinase pathway	P01179	PKB	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01160	IP3 receptor	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MOUSE|MGI=MGI=103189|UniProtKB=Q10738	Matrilysin	TAS	12834808	PubMed	PTHR10201:SF143	MATRILYSIN
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00045	Notch signaling pathway	P01101	Su(H)	ORNAN|Ensembl=ENSOANG00000006699|UniProtKB=F6ULE6	Uncharacterized protein	ISS	12145413	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	DAPPU|EnsemblGenome=DAPPUDRAFT_302845|UniProtKB=E9GER1	Putative uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00009	Axon guidance mediated by netrin	P00356	UNC-5	RAT|RGD=735109|UniProtKB=Q761X5	Netrin receptor UNC5C	ISS			PTHR12582:SF7	NETRIN RECEPTOR UNC5C
P00057	Wnt signaling pathway	P01444	Wnt	DANRE|ZFIN=ZDB-GENE-980526-352|UniProtKB=P47793	Protein Wnt-4a	IDA	8717036	PubMed	PTHR12027:SF103	PROTEIN WNT-4A
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00774	Dynein complex	SCHPO|PomBase=SPAC926.07c|UniProtKB=Q9UR05	Dynein light chain 1, cytoplasmic	IPI	9454836	PubMed	PTHR11886:SF35	DYNEIN LIGHT CHAIN 2, CYTOPLASMIC
P00021	FGF signaling pathway	P00629	PP2A	MACMU|Ensembl=ENSMMUG00000020819|UniProtKB=F7HSM1	Serine/threonine-protein phosphatase	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01465	Ggamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00046	Oxidative stress response	P01138	MKK4	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS	12878610	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00053	T cell activation	P01306	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	DANRE|ZFIN=ZDB-GENE-030131-8013|UniProtKB=F1QBT6	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P02761	Pantothenate biosynthesis	P03067	3-methyl-2-oxobutanoate hydroxymethyltransferase	THEMA|EnsemblGenome=TM_1728|UniProtKB=Q9X251	3-methyl-2-oxobutanoate hydroxymethyltransferase	ISS			PTHR20881:SF0	3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00047	PDGF signaling pathway	P01175	Shc	MACMU|Ensembl=ENSMMUG00000020357|UniProtKB=F6W915	SHC-transforming protein 3	ISS	98175964	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=5292|UniProtKB=P30939	5-hydroxytryptamine receptor 1F	IDA	1608964	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00021	FGF signaling pathway	P00646	RasGAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CANLF|Gene=GRIN1|UniProtKB=Q5R1P0	Glutamate receptor ionotropic, NMDA 1	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000017387|UniProtKB=E2RLD1	Uncharacterized protein	ISS	12507995	PubMed	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00012	Cadherin signaling pathway	P00470	F-actin	XENTR|Xenbase=XB-GENE-491618|UniProtKB=Q6P378	Actin, cytoplasmic 2	ISS	11889139	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IGI	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MONDO|Ensembl=ENSMODG00000014313|UniProtKB=F7BTW0	Ribosomal protein S6 kinase	ISS	15116068	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	SCHPO|PomBase=SPAC458.05|UniProtKB=P50520	Phosphatidylinositol 3-kinase vps34	IC	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00011	Blood coagulation	P00458	GP IIIa	MACMU|Ensembl=ENSMMUG00000003289|UniProtKB=F7FG54	Integrin beta	ISS	280842	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00056	VEGF signaling pathway	P01425	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	15572354	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00019	Endothelin signaling pathway	P00566	ERK	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	PHYIT|EnsemblGenome=PITG_15078|UniProtKB=D0NRL5	Actin-like protein	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02776	Serine glycine biosynthesis	P03159	Phosphoserine phosphatase	MYCTU|EnsemblGenome=Rv3042c|UniProtKB=O53289	Probable phosphoserine phosphatase SerB2 (PSP) (O-phosphoserine phosphohydrolase) (Pspase)	ISS			PTHR43344:SF2	PHOSPHOSERINE PHOSPHATASE
P00049	Parkinson disease	P01211	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00206	Wnt	MONDO|Ensembl=ENSMODG00000015792|UniProtKB=Q2QL96	Protein Wnt-2	ISS	11266476	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00019	Endothelin signaling pathway	P00582	COX-2	RAT|RGD=620349|UniProtKB=P35355	Prostaglandin G/H synthase 2	IGI	12163371	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P00057	Wnt signaling pathway	P01451	Galpha	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	IDA	1650351	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00047	PDGF signaling pathway	P01162	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00010	B cell activation	P00391	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01230	Src kinase	MONDO|Ensembl=ENSMODG00000000247|UniProtKB=F6WR53	Tyrosine-protein kinase	ISS	8054685	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DANRE|ZFIN=ZDB-GENE-010705-1|UniProtKB=Q90Z40	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00019	Endothelin signaling pathway	P00587	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00541	Spry	DROME|FlyBase=FBgn0014388|UniProtKB=O44783	Protein sprouty	IGI	98117253	PubMed	PTHR12365:SF7	PROTEIN SPROUTY
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00025	Hedgehog signaling pathway	P00682	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P06664	Gonadotropin-releasing hormone receptor pathway	P06705	PLCbeta	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	RCA	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00054	Toll receptor signaling pathway	P01360	IKKbeta	MACMU|Ensembl=ENSMMUG00000008351|UniProtKB=F7HRV5	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00036	Interleukin signaling pathway	P00973	PKB	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P05999	provasopressin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04393	Ras Pathway	P04566	Stat 1/3	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	12191995	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MACMU|Ensembl=ENSMMUG00000010266|UniProtKB=F6PV18	Uncharacterized protein	ISS	14500986	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	TAS			PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00029	Huntington disease	P00805	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	MACMU|Ensembl=ENSMMUG00000014702|UniProtKB=F7GSG6	Transcription initiation factor TFIID subunit 2	ISS			PTHR15137:SF9	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00059	p53 pathway	P04623	CBP	ARATH|TAIR=AT1G79000|UniProtKB=Q9C5X9	Histone acetyltransferase HAC1	ISS	10769018	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00053	T cell activation	P01294	NFAT	HUMAN|HGNC=7778|UniProtKB=Q14934	Nuclear factor of activated T-cells, cytoplasmic 4	IGI	12787506	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04398	p53 pathway feedback loops 2	P04668	p53	HUMAN|HGNC=15979|UniProtKB=Q9H3D4	Tumor protein 63	TAS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P04393	Ras Pathway	P04552	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000016097|UniProtKB=E1B9S9	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00056	VEGF signaling pathway	P01402	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	RCA			PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04398	p53 pathway feedback loops 2	P04651	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P02731	Biotin biosynthesis	P02857	Biotin synthase	YEAST|SGD=S000003518|UniProtKB=P32451	Biotin synthase, mitochondrial	ISS			PTHR22976:SF1	BIOTIN SYNTHASE, MITOCHONDRIAL
P00011	Blood coagulation	P00430	FX	PANTR|Ensembl=ENSPTRG00000006050|UniProtKB=H2Q7T9	Coagulation factor X	ISS	4503625	gi	PTHR44064:SF3	COAGULATION FACTOR X
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	CAEBR|Gene=CBG20640|UniProtKB=A8XY98	Protein CBG20640	ISS			PTHR20852:SF57	GLUTAMINE SYNTHETASE 2 CYTOPLASMIC
P00012	Cadherin signaling pathway	P00470	F-actin	TAKRU|Ensembl=ENSTRUG00000005494|UniProtKB=P53483	Actin, alpha anomalous	IC	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IC	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	MACMU|Ensembl=ENSMMUG00000006000|UniProtKB=F6UDV1	Aspartate aminotransferase	ISS			PTHR11879:SF32	ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL
P02747	Histidine biosynthesis	P02987	ATP phosphoribosyl transferase	METAC|EnsemblGenome=MA_0217|UniProtKB=Q8TU56	ATP phosphoribosyltransferase	ISS			PTHR21403:SF0	ATP PHOSPHORIBOSYLTRANSFERASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TRIAD|EnsemblGenome=TriadG63375|UniProtKB=B3S5E4	Non-muscle actin 6.2	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	MONDO|Ensembl=ENSMODG00000014177|UniProtKB=F6U7A6	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	G01511	SPRY	RAT|RGD=1311472|UniProtKB=Q5HZA2	Protein Spry2	IGI	12402043	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P05730	Endogenous cannabinoid signaling	P05751	Galpha	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P02775	Salvage pyrimidine ribonucleotides	P03149	Cytidine kinase	CAEBR|Gene=CBG03314|UniProtKB=A8WUR5	Uridine kinase	ISS			PTHR10285:SF123	URIDINE KINASE
P00036	Interleukin signaling pathway	P00965	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	CAEBR|Gene=CBG06092|UniProtKB=A8X0X5	Protein CBR-LET-60	ISS	12024031	PubMed	PTHR24070:SF385	GTPASE HRAS
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	MACMU|Ensembl=ENSMMUG00000000289|UniProtKB=F7A9T0	Uncharacterized protein	ISS	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00034	Integrin signalling pathway	P00940	Src	DROME|FlyBase=FBgn0262733|UniProtKB=P00528	Tyrosine-protein kinase Src64B	IPI	8054685	PubMed	PTHR24418:SF283	TYROSINE-PROTEIN KINASE SRC64B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	STRPU|EnsemblGenome=SPU_006797|UniProtKB=W4XTP5	Uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MACMU|Ensembl=ENSMMUG00000019112|UniProtKB=F6T8S6	N-methyl D-aspartate receptor subtype 2B	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00057	Wnt signaling pathway	P01451	Galpha	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BOVIN|Gene=ACTB|UniProtKB=P60712	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04371	5-Hydroxytryptamine biosynthesis	P04400	Aromatic L-amino acid decarboxylase	CAEBR|Gene=CBG08967|UniProtKB=A8X844	Protein CBR-BAS-1	ISS	7567987	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000003399|UniProtKB=H2Q383	Phosphoinositide-3-kinase, class 2, alpha polypeptide	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000017739|UniProtKB=F7F3W3	Uncharacterized protein	ISS			PTHR43962:SF6	MELATONIN RECEPTOR TYPE 1B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	P17325	SPACC	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00030	Hypoxia response via HIF activation	P00814	P300	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P02743	Formyltetrahydroformate biosynthesis	P02952	Methylene tetrahydrofolate dehydrogenase	METAC|EnsemblGenome=MA_3519|UniProtKB=Q8TK95	Bifunctional protein FolD	ISS			PTHR10025:SF46	BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, MITOCHONDRIAL
P00056	VEGF signaling pathway	P01423	p38MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	HUMAN|HGNC=4404|UniProtKB=P59768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P05914	Nicotine degradation	P05984	CYP2A6	HUMAN|HGNC=2608|UniProtKB=Q16696	Cytochrome P450 2A13	TAS			PTHR24300:SF180	CYTOCHROME P450 2A13
P00018	EGF receptor signaling pathway	P00545	JNK1-3	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04395	Vasopressin synthesis	P04596	Endo Peptidase	PANTR|Ensembl=ENSPTRG00000011884|UniProtKB=H2QHU5	Prolyl endopeptidase-like	ISS	9695945	PubMed	PTHR11757:SF12	PROLYL ENDOPEPTIDASE-LIKE
P00006	Apoptosis signaling pathway	P00269	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00049	Parkinson disease	P01238	14-3-3	HUMAN|HGNC=12854|UniProtKB=P27348	14-3-3 protein theta	IDA	7603573	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00054	Toll receptor signaling pathway	P01369	MKK1	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IC	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00018	EGF receptor signaling pathway	P00562	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04395	Vasopressin synthesis	P04597	Signal Peptide	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	BOVIN|Gene=IGF2R|UniProtKB=P08169	Cation-independent mannose-6-phosphate receptor	ISS	11081635	PubMed	PTHR15071:SF17	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	IXOSC|EnsemblGenome=ISCW020789|UniProtKB=B7PXR7	Putative uncharacterized protein (Fragment)	ISS			PTHR11079:SF149	TRNA-SPECIFIC ADENOSINE DEAMINASE
P00049	Parkinson disease	P01238	14-3-3	SCHPO|PomBase=SPAC8E11.02c|UniProtKB=P42656	DNA damage checkpoint protein rad24	IDA	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00034	Integrin signalling pathway	P00938	Cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00019	Endothelin signaling pathway	P00590	IP3 R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00007	Axon guidance mediated by semaphorins	P00340	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	MACMU|Ensembl=ENSMMUG00000005362|UniProtKB=F7GAS0	Uncharacterized protein	ISS			PTHR11079:SF92	TRNA-SPECIFIC ADENOSINE DEAMINASE 2
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000022000|UniProtKB=Q9MZL5	Voltage-dependent L-type calcium channel subunit beta-2	IC	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00029	Huntington disease	P00786	ARF	CANLF|Ensembl=ENSCAFG00000029422|UniProtKB=J9NWP6	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P06664	Gonadotropin-releasing hormone receptor pathway	P06769	Gbeta	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	RCA	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-040426-2427|UniProtKB=F1Q6C0	Uncharacterized protein (Fragment)	ISS	3037538	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT3G45640|UniProtKB=Q39023	Mitogen-activated protein kinase 3	ISS	9836510	gi	PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	PANTR|Ensembl=ENSPTRG00000018640|UniProtKB=H2QTT2	Uncharacterized protein	ISS	11163236	PubMed	PTHR20859:SF21	INTERLEUKIN-20 RECEPTOR SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01151	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04393	Ras Pathway	P04557	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IDA	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	CHICK|Ensembl=ENSGALG00000011905|UniProtKB=F1NHT7	Uncharacterized protein	IDA	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MONDO|Ensembl=ENSMODG00000020204|UniProtKB=F6SED9	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00760	Gtalpha	BOVIN|Ensembl=ENSBTAG00000018020|UniProtKB=P04695	Guanine nucleotide-binding protein G(t) subunit alpha-1	IDA	6264430	PubMed	PTHR10218:SF67	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	SCHPO|PomBase=SPAC1F7.05|UniProtKB=P36602	Ribonucleoside-diphosphate reductase large chain	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00049	Parkinson disease	P01212	p38 MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00035	Interferon-gamma signaling pathway	P00960	PTP	MACMU|Ensembl=ENSMMUG00000013253|UniProtKB=F6ZJD8	Tyrosine-protein phosphatase non-receptor type	ISS	14525967	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00018	EGF receptor signaling pathway	P00545	JNK1-3	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00053	T cell activation	P01311	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00371	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00887	IRS 1-4	MOUSE|MGI=MGI=1194882|UniProtKB=O54718	Insulin receptor substrate 3, isoform CRA_a (Fragment)	ISS	5031805	gi	PTHR10614:SF8	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00805	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	MOUSE|MGI=MGI=96553|UniProtKB=P26952	Interleukin-3 receptor subunit alpha	IPI	1582416	PubMed	PTHR23036:SF107	INTERLEUKIN-3 RECEPTOR SUBUNIT ALPHA
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	MONDO|Ensembl=ENSMODG00000008641|UniProtKB=F6PGG8	Uncharacterized protein	ISS	14724059	PubMed	PTHR11699:SF102	RETINAL DEHYDROGENASE 2
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	HUMAN|HGNC=3342|UniProtKB=Q05925	Homeobox protein engrailed-1	IEP	12356903	PubMed	PTHR24341:SF4	HOMEOBOX PROTEIN ENGRAILED-1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	TAKRU|Ensembl=ENSTRUG00000018612|UniProtKB=H2VEM3	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF18	PROTEIN-SERINE/THREONINE KINASE
P00012	Cadherin signaling pathway	P00466	EGFR	MONDO|Ensembl=ENSMODG00000015755|UniProtKB=F6ZSZ9	Uncharacterized protein (Fragment)	ISS	4884676	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P05916	Opioid prodynorphin pathway	P06002	G-protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00010	B cell activation	P00384	p38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IDA	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	XENTR|Xenbase=XB-GENE-483455|UniProtKB=Q0IHM5	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	TAKRU|Ensembl=ENSTRUG00000016101|UniProtKB=H2UW32	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00012	Cadherin signaling pathway	P00470	F-actin	MACMU|Ensembl=ENSMMUG00000001353|UniProtKB=F7D6T8	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P06664	Gonadotropin-releasing hormone receptor pathway	G06898	PAC1R	MOUSE|MGI=MGI=108449|UniProtKB=P70205	Pituitary adenylate cyclase-activating polypeptide type I receptor	RCA			PTHR12011:SF228	PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE TYPE I RECEPTOR
P05913	Enkephalin release	P05972	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	XENTR|Xenbase=XB-GENE-491433|UniProtKB=B1H2U0	Pten protein	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P02785	Valine biosynthesis	P03216	Acetolactate synthase	BACSU|EnsemblGenome=BSU28310|UniProtKB=P37251	Acetolactate synthase large subunit	ISS			PTHR18968:SF116	ACETOLACTATE SYNTHASE ISOZYME 3 LARGE SUBUNIT
P00047	PDGF signaling pathway	P01154	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=11330|UniProtKB=P30872	Somatostatin receptor type 1	IDA	12181435	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P00029	Huntington disease	P00810	GAPDH	SYNY3|EnsemblGenome=BAA18633|UniProtKB=P80505	Glyceraldehyde-3-phosphate dehydrogenase 2	ISS			PTHR43148:SF2	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE C-RELATED
P00018	EGF receptor signaling pathway	P00558	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000025240|UniProtKB=F7A7I3	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P06664	Gonadotropin-releasing hormone receptor pathway	P06820	alpha-beta integrin dimer	MOUSE|MGI=MGI=96599|UniProtKB=Q3V3R4	Integrin alpha-1	RCA	3487386	PubMed	PTHR23220:SF22	INTEGRIN ALPHA-1
P00012	Cadherin signaling pathway	P00467	alpha-catenin	MOUSE|MGI=MGI=88274|UniProtKB=P26231	Catenin alpha-1	IDA	1768802	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P05918	p38 MAPK pathway	P06026	MEKK4	CANLF|Ensembl=ENSCAFG00000000760|UniProtKB=E2R9L4	Uncharacterized protein	ISS	602425	OMIM	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00059	p53 pathway	G04694	p110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05731	GABA-B receptor II signaling	P05754	Ggamma	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	BOVIN|Ensembl=ENSBTAG00000011802|UniProtKB=E1BI98	Uncharacterized protein	ISS	10778855	PubMed	PTHR44172:SF3	COLLAGEN ALPHA-1 VI  CHAIN
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MONDO|Ensembl=ENSMODG00000010644|UniProtKB=F7D4J8	Protein Wnt (Fragment)	ISS	8717036	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00833	RGS	MONDO|Ensembl=ENSMODG00000008463|UniProtKB=F7GET1	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF196	REGULATOR OF G-PROTEIN SIGNALING 17
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	DANRE|ZFIN=ZDB-GENE-050417-59|UniProtKB=Q15KE4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00036	Interleukin signaling pathway	P00973	PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	ANOGA|EnsemblGenome=AGAP002971|UniProtKB=Q7PQY4	AGAP002971-PA	IC	85270494	PubMed	PTHR18945:SF505	ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 2
P06664	Gonadotropin-releasing hormone receptor pathway	P06738	PLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	RCA	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00001	Adrenaline and noradrenaline biosynthesis	P00062	TH	MOUSE|MGI=MGI=98735|UniProtKB=P24529	Tyrosine 3-monooxygenase	ISS	191290	OMIM	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P04372	5-Hydroxytryptamine degredation	P04401	Monoamine Oxidase	DANRE|ZFIN=ZDB-GENE-040329-3|UniProtKB=Q6NSN2	Amine oxidase [flavin-containing]	ISS	90344230	PubMed	PTHR43563:SF2	AMINE OXIDASE  FLAVIN-CONTAINING
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CRYNJ|EnsemblGenome=CNA04650|UniProtKB=Q5KP06	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00024	Glycolysis	P00679	Aldolase	MOUSE|MGI=MGI=2447811|UniProtKB=A6ZI46	Fructose-bisphosphate aldolase	ISS	4812352	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00018	EGF receptor signaling pathway	P00562	p38	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	IDA	1169551	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P02726	Aminobutyrate degradation	P02825	4-aminobutyrate aminotransferase	PANTR|Ensembl=ENSPTRG00000007746|UniProtKB=H2QAJ4	4-aminobutyrate aminotransferase	ISS	2496985	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00034	Integrin signalling pathway	P00927	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00049	Parkinson disease	P01208	Hsp70	MONDO|Ensembl=ENSMODG00000003386|UniProtKB=F6Z1G9	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF210	HEAT SHOCK 70 KDA PROTEIN 1-LIKE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000002016|UniProtKB=F1P3G1	Protein kinase C delta type	ISS	11880265	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	TAKRU|Ensembl=ENSTRUG00000002863|UniProtKB=H2S2N9	Uncharacterized protein	ISS	1768802	PubMed	PTHR18914:SF29	CATENIN ALPHA-2
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04395	Vasopressin synthesis	P04589	Signal Peptidase	MACMU|Ensembl=ENSMMUG00000011486|UniProtKB=F7D839	Signal peptidase complex catalytic subunit SEC11	ISS	2674115	PubMed	PTHR10806:SF8	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11A-RELATED
P00054	Toll receptor signaling pathway	P01358	ERK1	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	CANLF|Gene=CXCR2|UniProtKB=O97571	C-X-C chemokine receptor type 2	ISS	4504683	gi	PTHR10489:SF689	C-X-C CHEMOKINE RECEPTOR TYPE 2
P02785	Valine biosynthesis	P03218	Dihydroxy isovalerate dehydratase	STRCO|Gene=CAB61588|UniProtKB=Q9RJZ4	Putative dihydroxy-acid dehydratase	ISS			PTHR43183:SF3	SUBFAMILY NOT NAMED
P02747	Histidine biosynthesis	P02988	Histidinal dehydrogenase	YEAST|SGD=S000000535|UniProtKB=P00815	Histidine biosynthesis trifunctional protein	ISS			PTHR21256:SF2	HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN
P00056	VEGF signaling pathway	P01425	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00006	Apoptosis signaling pathway	P00321	HSP70	ARATH|TAIR=AT1G56410|UniProtKB=Q9C7X7	Heat shock 70 kDa protein 18	ISS	12150907	PubMed	PTHR19375:SF323	HEAT SHOCK 70 KDA PROTEIN 18-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	BOVIN|Ensembl=ENSBTAG00000003043|UniProtKB=P63212	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00048	PI3 kinase pathway	P01199	Galpha	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	IC	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01324	rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	IDA	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01177	P110ACT	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01067	AChE	BOVIN|Ensembl=ENSBTAG00000011139|UniProtKB=P32749	Cholinesterase	ISS	86008285	PubMed	PTHR43918:SF5	CHOLINESTERASE
P02788	Xanthine and guanine salvage pathway	P03250	Guanosine phosphorylase	ANOGA|EnsemblGenome=AGAP005945|UniProtKB=A4Q998	AGAP005945-PA	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	CRYNJ|EnsemblGenome=CND03830|UniProtKB=Q5KI86	Uncharacterized protein	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	RAT|RGD=3852|UniProtKB=P80204	TGF-beta receptor type-1	TAS	10683140	PubMed	PTHR23255:SF61	TGF-BETA RECEPTOR TYPE-1
P00048	PI3 kinase pathway	P01185	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P06664	Gonadotropin-releasing hormone receptor pathway	P06705	PLCbeta	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	RCA	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	CHICK|Ensembl=ENSGALG00000008058|UniProtKB=F1N8W8	Uncharacterized protein	ISS	11259591	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00007	Axon guidance mediated by semaphorins	P00340	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00010	B cell activation	P00391	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P02777	Succinate to proprionate conversion	P03163	Methylmalonyl-CoA decarboxylase	HUMAN|HGNC=21489|UniProtKB=Q9NTX5	Ethylmalonyl-CoA decarboxylase	RCA			PTHR11941:SF27	ETHYLMALONYL-COA DECARBOXYLASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P05913	Enkephalin release	G06045	preproenkephalin	RAT|RGD=62054|UniProtKB=P06300	Proenkephalin-B	ISS	131330	OMIM	PTHR11438:SF4	PROENKEPHALIN-B
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	SCHPO|PomBase=SPAC1556.04c|UniProtKB=Q09190	Putative cytidine deaminase	ISS			PTHR11644:SF2	CYTIDINE DEAMINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00539	14-3-3	CANLF|Ensembl=ENSCAFG00000000580|UniProtKB=F1PBL1	Uncharacterized protein	ISS	92283271	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00047	PDGF signaling pathway	P01161	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00983	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00037	Ionotropic glutamate receptor pathway	P01026	KA	RAT|RGD=2732|UniProtKB=P22756	Glutamate receptor ionotropic, kainate 1	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	ORYSJ|EnsemblGenome=OS03G0763000|UniProtKB=Q8W5G9	Casein kinase II, alpha chain, putative, expressed	IDA	10617630	PubMed	PTHR24054:SF33	CASEIN KINASE II SUBUNIT ALPHA, CHLOROPLASTIC
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BOVIN|Ensembl=ENSBTAG00000016012|UniProtKB=F1N5R1	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00983	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	3449797	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00057	Wnt signaling pathway	P01465	Ggamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00057	Wnt signaling pathway	P01451	Galpha	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MACMU|Ensembl=ENSMMUG00000022808|UniProtKB=F6UWC3	Actin-related protein 2/3 complex subunit 2	ISS	17943202	gi	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00059	p53 pathway	P04618	PML	PANTR|Ensembl=ENSPTRG00000007266|UniProtKB=Q15JE1	Promyelocytic leukemia	ISS	14992722	PubMed	PTHR45211:SF1	PROTEIN PML
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CANLF|Ensembl=ENSCAFG00000015662|UniProtKB=E2RHY4	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00053	T cell activation	P01319	PAK	MOUSE|MGI=MGI=1339984|UniProtKB=Q8CIN4	Serine/threonine-protein kinase PAK 2	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000002016|UniProtKB=F1P3G1	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CAEEL|WormBase=WBGene00000067|UniProtKB=O45815	ACTin	ISS	3487386	PubMed	PTHR11937:SF352	ACTIN
P02746	Heme biosynthesis	P02982	Protoheme IX farnesyl transferase	BRADU|EnsemblGenome=BAC46437|UniProtKB=Q9RM98	Protoheme IX farnesyltransferase	ISS			PTHR43448:SF2	PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01438	PP2A	XENTR|Xenbase=XB-GENE-957248|UniProtKB=Q6GLE6	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01311	Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	IDA	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00019	Endothelin signaling pathway	P00573	signal peptidase	CAEEL|WormBase=WBGene00021844|UniProtKB=Q9N3D0	Signal peptidase complex catalytic subunit SEC11	ISS	2092035	PubMed	PTHR10806:SF6	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11
P00010	B cell activation	P00383	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00049	Parkinson disease	P01211	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00018	EGF receptor signaling pathway	P00551	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00025	Hedgehog signaling pathway	P00682	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00470	F-actin	HUMAN|HGNC=169|UniProtKB=P61160	Actin-related protein 2	ISS	11889126	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00059	p53 pathway	P01486	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00034	Integrin signalling pathway	P00944	Actin	RAT|RGD=1304556|UniProtKB=P63259	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00021	FGF signaling pathway	P00627	ERK1-2	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01171	PLCgamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	PANTR|Ensembl=ENSPTRG00000002371|UniProtKB=H2Q1R1	Uncharacterized protein	ISS	22028976	PubMed	PTHR13140:SF387	MYOSIN-IIIA
P00056	VEGF signaling pathway	P01407	Erk	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00128	Erb-B4	CHICK|Ensembl=ENSGALG00000003126|UniProtKB=F1P258	Receptor protein-tyrosine kinase	ISS	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00313	IKK	MOUSE|MGI=MGI=99484|UniProtKB=Q60680	Inhibitor of nuclear factor kappa-B kinase subunit alpha	ISS	14499113	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P02775	Salvage pyrimidine ribonucleotides	P03153	Cytidylate kinase	MOUSE|MGI=MGI=1913838|UniProtKB=Q9DBP5	UMP-CMP kinase	ISS			PTHR23359:SF107	UMP-CMP KINASE
P00029	Huntington disease	G01535	PIG3	MACMU|Ensembl=ENSMMUG00000011797|UniProtKB=F7HNA8	Synaptic vesicle membrane protein VAT-1 homolog-like	ISS	12932731	PubMed	PTHR44054:SF2	SYNAPTIC VESICLE MEMBRANE PROTEIN VAT-1 HOMOLOG-LIKE
P00017	DNA replication	P00536	DNA Topisomerase	ARATH|TAIR=AT3G23890|UniProtKB=P30182	DNA topoisomerase 2	ISS			PTHR10169:SF38	DNA TOPOISOMERASE 2
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00036	Interleukin signaling pathway	P00990	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	MOUSE|MGI=MGI=103249|UniProtKB=P62204	Calmodulin	ISS			PTHR23050:SF311	CALMODULIN
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000009766|UniProtKB=F6TFL4	Uncharacterized protein	ISS	8444355	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	MONDO|Ensembl=ENSMODG00000005404|UniProtKB=F7G632	Uncharacterized protein (Fragment)	ISS			PTHR42884:SF13	NEUROENDOCRINE CONVERTASE 2
P05915	Opioid proenkephalin pathway	P05991	Enkephalin	XENTR|Xenbase=XB-GENE-942760|UniProtKB=F6Y5F6	Uncharacterized protein	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00018	EGF receptor signaling pathway	P00564	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	IPI	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06712	PAC1-R	MOUSE|MGI=MGI=108449|UniProtKB=P70205	Pituitary adenylate cyclase-activating polypeptide type I receptor	RCA			PTHR12011:SF228	PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE TYPE I RECEPTOR
P00005	Angiogenesis	P00213	FGF	PANTR|Ensembl=ENSPTRG00000017361|UniProtKB=H2QRP4	Fibroblast growth factor	ISS	12799194	PubMed	PTHR11486:SF86	FIBROBLAST GROWTH FACTOR 1
P00019	Endothelin signaling pathway	P00572	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00048	PI3 kinase pathway	P01190	PDK1 ACT	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P02761	Pantothenate biosynthesis	P03066	Aspartate decarboxylase	RHOBA|EnsemblGenome=RB6090|UniProtKB=Q7UQU4	Aspartate 1-decarboxylase	ISS			PTHR21012:SF0	ASPARTATE 1-DECARBOXYLASE
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000004896|UniProtKB=F7C2C6	Uncharacterized protein (Fragment)	ISS	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04558	p38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00019	Endothelin signaling pathway	P00587	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00547	PP2A	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	HUMAN|HGNC=712|UniProtKB=P32121	Beta-arrestin-2	IDA	11742073	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00046	Oxidative stress response	P01129	JNK1/2	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	TAS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00005	Angiogenesis	P00206	Wnt	RAT|RGD=628850|UniProtKB=B1WBR9	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DANRE|ZFIN=ZDB-GENE-000329-3|UniProtKB=Q7ZVF9	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00048	PI3 kinase pathway	P01199	Galpha	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04393	Ras Pathway	P04541	p90RSK	BOVIN|Ensembl=ENSBTAG00000014447|UniProtKB=A4IFF4	Ribosomal protein S6 kinase	ISS	2779569	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=94925|UniProtKB=P30728	D(3) dopamine receptor	IDA	11861492	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00057	Wnt signaling pathway	P01452	NFAT	BOVIN|Ensembl=ENSBTAG00000004368|UniProtKB=F1MSU2	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00006	Apoptosis signaling pathway	P00260	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01020	NSF	PANTR|Ensembl=ENSPTRG00000009320|UniProtKB=H2QD95	N-ethylmaleimide-sensitive factor	ISS	11348590	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00034	Integrin signalling pathway	P00907	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P06959	CCKR signaling map	P07041	SP3	HUMAN|HGNC=11208|UniProtKB=Q02447	Transcription factor Sp3	RCA	15109306	PubMed	PTHR23235:SF3	TRANSCRIPTION FACTOR SP3
P00034	Integrin signalling pathway	P00916	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00049	Parkinson disease	P01224	UbcH7	PANTR|Ensembl=ENSPTRG00000005754|UniProtKB=H2Q7D5	Uncharacterized protein	RCA			PTHR24068:SF67	UBIQUITIN-CONJUGATING ENZYME E2 L3
P00053	T cell activation	P01298	NFkappaB	CANLF|Ensembl=ENSCAFG00000010155|UniProtKB=E2RLL2	Uncharacterized protein	ISS	9133421	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	RAT|RGD=619729|UniProtKB=O88204	Low-density lipoprotein receptor-related protein 3	IDA	11907044	PubMed	PTHR44062:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 3
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CHICK|Ensembl=ENSGALG00000014539|UniProtKB=F1N861	Uncharacterized protein	ISS	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00059	p53 pathway	P04611	P300	MACMU|Ensembl=ENSMMUG00000000893|UniProtKB=F6T7D0	Histone acetyltransferase p300	ISS	10823891	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DROME|FlyBase=FBgn0000489|UniProtKB=P16912	Protein kinase DC2	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04393	Ras Pathway	P04558	p38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00542	EGFR	MONDO|Ensembl=ENSMODG00000015755|UniProtKB=F6ZSZ9	Uncharacterized protein (Fragment)	ISS	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00012	Cadherin signaling pathway	P00464	Fyn	MOUSE|MGI=MGI=95602|UniProtKB=P39688	Tyrosine-protein kinase Fyn	ISS	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00056	VEGF signaling pathway	P01419	Ets	MOUSE|MGI=MGI=95455|UniProtKB=P27577	Protein C-ets-1	ISS	15298723	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	HUMAN|HGNC=11641|UniProtKB=Q9NQB0	Transcription factor 7-like 2	TAS	12356903	PubMed	PTHR10373:SF32	TRANSCRIPTION FACTOR 7-LIKE 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	DAPPU|EnsemblGenome=DAPPUDRAFT_442795|UniProtKB=E9H5Z2	Calmodulin	ISS	7514101	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00005	Angiogenesis	P00207	Crk	CHICK|Ensembl=ENSGALG00000002656|UniProtKB=Q04929	Adapter molecule crk	ISS			PTHR19969:SF8	ADAPTER MOLECULE CRK
P00001	Adrenaline and noradrenaline biosynthesis	P00070	VAT2	MOUSE|MGI=MGI=106677|UniProtKB=Q8BRU6	Synaptic vesicular amine transporter	IC	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00021	FGF signaling pathway	P00648	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IGI	10395542	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P05918	p38 MAPK pathway	P06033	TAB2	RAT|RGD=1309527|UniProtKB=Q5U303	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2	ISS			PTHR10351:SF27	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 2
P00025	Hedgehog signaling pathway	P00682	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02920	dCTP deaminase	HUMAN|HGNC=21172|UniProtKB=Q7Z6V5	tRNA-specific adenosine deaminase 2	ISS			PTHR11079:SF92	TRNA-SPECIFIC ADENOSINE DEAMINASE 2
P00036	Interleukin signaling pathway	P00968	Ikk	HUMAN|HGNC=1974|UniProtKB=O15111	Inhibitor of nuclear factor kappa-B kinase subunit alpha	IDA	9346484	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00117	E-cadherin C-terminal fragment	PANTR|Ensembl=ENSPTRG00000008270|UniProtKB=H2QBE5	Uncharacterized protein	ISS	12834808	PubMed	PTHR24027:SF319	CADHERIN-1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CANLF|Ensembl=ENSCAFG00000005662|UniProtKB=E2R907	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01444	Wnt	DANRE|ZFIN=ZDB-GENE-980526-87|UniProtKB=Q92050	Protein Wnt-5b	IDA	8717036	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P04393	Ras Pathway	P04570	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00005	Angiogenesis	P00245	Rac	BOVIN|Ensembl=ENSBTAG00000016501|UniProtKB=F6RWK1	Uncharacterized protein	ISS	14724572	PubMed	PTHR23176:SF28	RHO GTPASE-ACTIVATING PROTEIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000002647|UniProtKB=F7DIB7	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00047	PDGF signaling pathway	P01150	PKC	PANTR|Ensembl=ENSPTRG00000000931|UniProtKB=H2PZC4	Protein kinase N2	ISS	11880265	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00021	FGF signaling pathway	P00642	MEK1-2	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02772	Pyruvate metabolism	P03134	Aminotransefrase	ARATH|TAIR=AT2G38400|UniProtKB=Q94AL9	Alanine--glyoxylate aminotransferase 2 homolog 2, mitochondrial	NAS	15028237	gi	PTHR11986:SF109	ALANINE--GLYOXYLATE AMINOTRANSFERASE 2-LIKE
P00053	T cell activation	P01322	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000006291|UniProtKB=F7GZ76	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF42	PROTOCADHERIN-12
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PANTR|Ensembl=ENSPTRG00000006890|UniProtKB=H2Q943	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	RAT|RGD=2744|UniProtKB=P31422	Metabotropic glutamate receptor 3	ISS	12351712	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	8837781	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	RAT|RGD=71034|UniProtKB=P32305	5-hydroxytryptamine receptor 7	IDA	12181435	PubMed	PTHR24247:SF116	5-HYDROXYTRYPTAMINE RECEPTOR 7
P06211	BMP/activin signaling pathway-drosophila	P06243	Smurf	DROME|FlyBase=FBgn0029006|UniProtKB=Q9V853	E3 ubiquitin-protein ligase Smurf1	RCA	http://flybase.org/reports/FBgn0029006.html	Website	PTHR11254:SF395	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01093	AChE	MACMU|Ensembl=ENSMMUG00000021257|UniProtKB=F7HPD6	Carboxylic ester hydrolase	ISS	86008285	PubMed	PTHR43918:SF3	ACETYLCHOLINESTERASE
P00052	TGF-beta signaling pathway	P01284	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	RCA	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00010	B cell activation	P00371	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00238	Ras	CHICK|Ensembl=ENSGALG00000006885|UniProtKB=P08642	GTPase HRas	ISS	87226391	PubMed	PTHR24070:SF385	GTPASE HRAS
P00046	Oxidative stress response	P01129	JNK1/2	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00049	Parkinson disease	P01242	Casein kinase I	PANTR|Ensembl=ENSPTRG00000017401|UniProtKB=H2R587	Casein kinase 1, alpha 1	ISS	10617630	PubMed	PTHR11909:SF84	CASEIN KINASE I ISOFORM ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01196	PDK1	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DANRE|ZFIN=ZDB-GENE-000329-1|UniProtKB=Q7ZVI7	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00021	FGF signaling pathway	P00627	ERK1-2	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01192	p110	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01443	Phospholipase C	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00029	Huntington disease	P00771	Sin3A	DROME|Gene=Dmel_CG8815|UniProtKB=A0A0B4K765	Sin3A, isoform G	IDA	10441327	PubMed	PTHR12346:SF0	SIN3A, ISOFORM G
P02748	Isoleucine biosynthesis	P02996	Ketol-acid reductoisomerase	STRCO|EnsemblGenome=CAC01643|UniProtKB=Q9FBT8	Ketol-acid reductoisomerase 2	ISS			PTHR21371:SF1	KETOL-ACID REDUCTOISOMERASE, CHLOROPLASTIC
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01185	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	7925653	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01093	AChE	MOUSE|MGI=MGI=894278|UniProtKB=Q03311	Cholinesterase	IC			PTHR43918:SF5	CHOLINESTERASE
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00036	Interleukin signaling pathway	P00975	RasGAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	2574500	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Gene=GRIK4|UniProtKB=Q5IS46	Glutamate receptor ionotropic, kainate 4	ISS	1648176	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00036	Interleukin signaling pathway	P00981	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	RAT|RGD=3273|UniProtKB=P28841	Neuroendocrine convertase 2	IDA			PTHR42884:SF13	NEUROENDOCRINE CONVERTASE 2
P00049	Parkinson disease	P01235	Fyn kinase	MACMU|Ensembl=ENSMMUG00000017017|UniProtKB=F7FVL2	Tyrosine-protein kinase	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00012	Cadherin signaling pathway	P00470	F-actin	MOUSE|MGI=MGI=87906|UniProtKB=P63260	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00004	Alzheimer disease-presenilin pathway	P00127	APP	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00030	Hypoxia response via HIF activation	P00818	HIF-1alpha	CHICK|Gene=HIF1A|UniProtKB=Q9YIB9	Hypoxia-inducible factor 1-alpha	ISS			PTHR23043:SF7	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA
P00005	Angiogenesis	P00189	Fzd	BOVIN|Ensembl=ENSBTAG00000002107|UniProtKB=A7MB15	FZD1 protein	ISS	8717036	PubMed	PTHR11309:SF81	FRIZZLED-1
P00034	Integrin signalling pathway	P00950	Paxillin	HUMAN|HGNC=9718|UniProtKB=P49023	Paxillin	ISS	7579684	PubMed	PTHR24216:SF11	PAXILLIN
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	XENTR|Xenbase=XB-GENE-976753|UniProtKB=Q0VFR6	Syntaxin 1A (Brain)	ISS	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	IDA	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05923	beta-ARR2	MACMU|Ensembl=ENSMMUG00000017654|UniProtKB=F6UI32	Beta-arrestin-2 isoform 1	ISS	11742073	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000013587|UniProtKB=F7AZ16	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF33	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-3
P00005	Angiogenesis	P00206	Wnt	ORNAN|Gene=WNT2|UniProtKB=Q07DZ8	Protein Wnt-2	ISS	8717036	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00020	FAS signaling pathway	P00612	Fas	HUMAN|HGNC=11920|UniProtKB=P25445	Tumor necrosis factor receptor superfamily member 6	TAS	14585074	PubMed	PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P05918	p38 MAPK pathway	P06034	MKK4	BOVIN|Ensembl=ENSBTAG00000012103|UniProtKB=A5PJP8	MAP2K4 protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00056	VEGF signaling pathway	P01411	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	XENTR|Xenbase=XB-GENE-484032|UniProtKB=F6QWD3	Tyrosine-protein kinase receptor	ISS	11182407	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	HUMAN|HGNC=4587|UniProtKB=Q14957	Glutamate receptor ionotropic, NMDA 2C	IC	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IDA	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00006	Apoptosis signaling pathway	P00302	ATF	MOUSE|MGI=MGI=109384|UniProtKB=Q60765	Cyclic AMP-dependent transcription factor ATF-3	ISS	11390664	PubMed	PTHR23351:SF23	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-3
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02759	Pyridoxal-5-phosphate biosynthesis	P03061	Pyridoxine-5-phosphate oxidase	MOUSE|MGI=MGI=2144151|UniProtKB=Q91XF0	Pyridoxine-5'-phosphate oxidase	ISS	9601034	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00009	Axon guidance mediated by netrin	P00364	cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MOUSE|MGI=MGI=101848|UniProtKB=P62881	Guanine nucleotide-binding protein subunit beta-5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004886|UniProtKB=H2Q5T7	Calcium channel, voltage-dependent, beta 3 subunit	ISS			PTHR11824:SF8	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00912	Arp2/3	HUMAN|HGNC=23366|UniProtKB=Q9BPX5	Actin-related protein 2/3 complex subunit 5-like protein	IPI	12932731	PubMed	PTHR12644:SF2	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5-LIKE PROTEIN
P00021	FGF signaling pathway	P00624	14-3-3	ORNAN|Ensembl=ENSOANG00000007305|UniProtKB=F6XW91	Uncharacterized protein	ISS	1499718	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	MACMU|Ensembl=ENSMMUG00000004886|UniProtKB=F7AGT9	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00005	Angiogenesis	P00203	Erk	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	15470041	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00048	PI3 kinase pathway	P01179	PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00273	p53	BOVIN|Ensembl=ENSBTAG00000001069|UniProtKB=P67939	Cellular tumor antigen p53	ISS	14744434	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00006	Apoptosis signaling pathway	P00310	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00004	Alzheimer disease-presenilin pathway	P00160	Nectin 1alpha	BOVIN|Ensembl=ENSBTAG00000015939|UniProtKB=F1MQJ3	Uncharacterized protein	ISS	12376527	PubMed	PTHR23277:SF69	NECTIN-1
P02738	De novo purine biosynthesis	P02889	dGDP kinase	DICDI|dictyBase=DDB_G0279911|UniProtKB=P34093	Nucleoside diphosphate kinase, mitochondrial	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g169611|UniProtKB=A7SEB1	Predicted protein	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	12855688	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05731	GABA-B receptor II signaling	P05754	Ggamma	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	RCA	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	MOUSE|MGI=MGI=2384795|UniProtKB=Q922W5	Pyrroline-5-carboxylate reductase 1, mitochondrial	ISS			PTHR11645:SF6	PYRROLINE-5-CARBOXYLATE REDUCTASE 1, MITOCHONDRIAL
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	PANTR|Ensembl=ENSPTRG00000011650|UniProtKB=H2QHF6	Uncharacterized protein	ISS			PTHR11482:SF42	ORNITHINE DECARBOXYLASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	RAT|RGD=1307690|UniProtKB=D4A0I8	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (Predicted), isoform CRA_b	ISS	12015605	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00034	Integrin signalling pathway	P00916	Ras	MACMU|Ensembl=ENSMMUG00000028733|UniProtKB=F6ZGX8	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF245	RAS-RELATED PROTEIN R-RAS
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02913	Thymidylate synthase	SCHPO|PomBase=SPAC15E1.04|UniProtKB=Q9UTI7	Probable thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008422|UniProtKB=F6VUT7	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00004	Alzheimer disease-presenilin pathway	P00123	CD44 C-terminal fragment	CHICK|Ensembl=ENSGALG00000007849|UniProtKB=F1NL98	Uncharacterized protein	IDA	14871815	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00059	p53 pathway	P01485	p53	DANRE|ZFIN=ZDB-GENE-990415-270|UniProtKB=P79734	Cellular tumor antigen p53	TAS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	PANTR|Ensembl=ENSPTRG00000005122|UniProtKB=H2Q6A6	Uncharacterized protein	ISS	11907044	PubMed	PTHR44025:SF2	PROLOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00023	General transcription regulation	P00658	TBP-associated factors	RAT|RGD=1305626|UniProtKB=Q5U1X0	Transcription initiation factor TFIID subunit 11	ISS			PTHR13218:SF8	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11
P00005	Angiogenesis	P00237	FRP	MACMU|Ensembl=ENSMMUG00000019082|UniProtKB=F6SGW3	Secreted frizzled-related protein 1	ISS	9096311	PubMed	PTHR11309:SF87	SECRETED FRIZZLED-RELATED PROTEIN 1
P00053	T cell activation	P01300	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00045	Notch signaling pathway	P01110	Presenilin	PANTR|Ensembl=ENSPTRG00000006510|UniProtKB=H2Q8K1	Presenilin	ISS	12736250	PubMed	PTHR10202:SF18	PRESENILIN-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00023	General transcription regulation	P00658	TBP-associated factors	BOVIN|Ensembl=ENSBTAG00000011339|UniProtKB=A7MAZ4	Transcription initiation factor TFIID subunit 8	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	IC	10514528	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	IC	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	ECOLI|EcoGene=EG10408|UniProtKB=P0A825	Serine hydroxymethyltransferase	ISS			PTHR11680:SF21	SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00922	Collagen	HUMAN|HGNC=2200|UniProtKB=P02458	Collagen alpha-1(II) chain	IDA	10778855	PubMed	PTHR24023:SF58	COLLAGEN ALPHA-1 II  CHAIN
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	IDA	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	IC	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00006	Apoptosis signaling pathway	P00282	IGFR2	PANTR|Ensembl=ENSPTRG00000018764|UniProtKB=H2QU01	Uncharacterized protein	ISS	11081635	PubMed	PTHR15071:SF17	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
P00006	Apoptosis signaling pathway	P00302	ATF	HUMAN|HGNC=784|UniProtKB=P15336	Cyclic AMP-dependent transcription factor ATF-2	ISS	9819389	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00012	Cadherin signaling pathway	P00466	EGFR	HUMAN|HGNC=3432|UniProtKB=Q15303	Receptor tyrosine-protein kinase erbB-4	ISS	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00048	PI3 kinase pathway	P01199	Galpha	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00053	T cell activation	P01312	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IDA	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00057	Wnt signaling pathway	P01465	Ggamma	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	ARATH|TAIR=AT5G44100|UniProtKB=Q9FFH8	At5g44100	IDA	10617630	PubMed	PTHR11909:SF114	ADK1-RELATED
P00048	PI3 kinase pathway	P01185	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IC	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	MACMU|Ensembl=ENSMMUG00000022513|UniProtKB=F6YNZ0	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00037	Ionotropic glutamate receptor pathway	P01020	NSF	RAT|RGD=621594|UniProtKB=Q9QUL6	Vesicle-fusing ATPase	ISS	601633	OMIM	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04392	P53 pathway feedback loops 1	P04539	p53	RAT|RGD=620863|UniProtKB=Q9JJP6	Tumor protein 63	TAS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PRIPA|Gene=PPA17339|UniProtKB=H3F5B4	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF352	ACTIN
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	MONBE|Gene=11217|UniProtKB=A9V8J8	Predicted protein	ISS	7514101	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00029	Huntington disease	P00790	beta-Tubulin	DANRE|ZFIN=ZDB-GENE-030131-7741|UniProtKB=Q6PE34	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF93	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00568	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	XENTR|Xenbase=XB-GENE-854877|UniProtKB=F7C949	Presenilin	ISS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	DROME|FlyBase=FBgn0004921|UniProtKB=P38040	Guanine nucleotide-binding protein subunit gamma-1	IC	3100519	PubMed	PTHR13809:SF3	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA-RELATED
P00048	PI3 kinase pathway	P01196	PDK1	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00047	PDGF signaling pathway	P01168	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00644	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	RAT|RGD=2740|UniProtKB=Q62645	Glutamate receptor ionotropic, NMDA 2D	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CHICK|Gene=CHRM3|UniProtKB=P49578	Muscarinic acetylcholine receptor M3	IDA	8100450	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	XENTR|Xenbase=XB-GENE-480347|UniProtKB=Q6P640	Actin, alpha cardiac muscle 1	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04393	Ras Pathway	P04568	MKK3/6	MACMU|Ensembl=ENSMMUG00000010904|UniProtKB=F7GLY5	Uncharacterized protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00036	Interleukin signaling pathway	P00996	STAT	DANRE|ZFIN=ZDB-GENE-980526-499|UniProtKB=Q6P943	Signal transducer and activator of transcription	IDA	99348060	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00011	Blood coagulation	P00443	Fibrin polymer cross-linked	CHICK|Gene=FGA|UniProtKB=P14448	Fibrinogen alpha chain	ISS	1706798	gi	PTHR19143:SF232	FIBRINOGEN ALPHA CHAIN
P00056	VEGF signaling pathway	P01413	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	ISS	10799299	PubMed	PTHR10048:SF14	PI-3 KINASE
P00010	B cell activation	P00369	MEKK	RAT|RGD=620967|UniProtKB=F1M9D0	Protein Map3k2	ISS	21735556	gi	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00034	Integrin signalling pathway	P00916	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P04393	Ras Pathway	P04555	PDK	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	IDA	15531926	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00059	p53 pathway	P01486	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01456	beta-arrestin	DANRE|ZFIN=ZDB-GENE-060824-1|UniProtKB=C3PTE8	Beta-arrestin 1	ISS	4757780	gi	PTHR11792:SF22	BETA-ARRESTIN-1
P00011	Blood coagulation	P00443	Fibrin polymer cross-linked	CHICK|Ensembl=ENSGALG00000009268|UniProtKB=E1BV78	Uncharacterized protein	ISS	3641556	gi	PTHR19143:SF338	FIBRINOGEN GAMMA CHAIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	8170357	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00048	PI3 kinase pathway	P01185	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	RAT|RGD=2739|UniProtKB=Q00961	Glutamate receptor ionotropic, NMDA 2C	ISS	11319238	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00021	FGF signaling pathway	P00648	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P02771	Pyrimidine Metabolism	P03128	Dihydrouracil Dehydrogenase	HUMAN|HGNC=3012|UniProtKB=Q12882	Dihydropyrimidine dehydrogenase [NADP(+)]	IDA	8083224	PubMed	PTHR43073:SF2	DIHYDROPYRIMIDINE DEHYDROGENASE  NADP +
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01070	K+ channel	CHICK|Ensembl=ENSGALG00000005822|UniProtKB=E1C3B4	Uncharacterized protein	ISS	12223552	PubMed	PTHR11537:SF6	POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 2
P00009	Axon guidance mediated by netrin	P00366	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12912997	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04398	p53 pathway feedback loops 2	P04651	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04393	Ras Pathway	P04574	PLD	ORYSJ|EnsemblGenome=OS06G0604200|UniProtKB=Q69X22	Phospholipase D	IDA	14581626	PubMed	PTHR18896:SF59	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00006	Apoptosis signaling pathway	P00260	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00555	MKK4,7	PANTR|Ensembl=ENSPTRG00000008783|UniProtKB=H2QCA7	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	SCHMA|EnsemblGenome=Smp_165490|UniProtKB=C1LZY9	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01211	ERK	MOUSE|MGI=MGI=2652894|UniProtKB=Q80Y86	Mitogen-activated protein kinase 15	ISS	10514528	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	BOVIN|Ensembl=ENSBTAG00000011723|UniProtKB=E1BKL6	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	9860142	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05918	p38 MAPK pathway	P06024	eIF4E	MOUSE|MGI=MGI=95305|UniProtKB=P63073	Eukaryotic translation initiation factor 4E	ISS			PTHR11960:SF14	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	RAT|RGD=3772|UniProtKB=P52631	Signal transducer and activator of transcription 3	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CANLF|Ensembl=ENSCAFG00000013332|UniProtKB=F1PCQ4	Uncharacterized protein	ISS	10487205	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01063	CAT	CAEEL|WormBase=WBGene00000481|UniProtKB=P32756	Choline O-acetyltransferase	ISS	92155737	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	HUMAN|HGNC=6091|UniProtKB=P06213	Insulin receptor	ISS	249616	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00546	GAP	HUMAN|HGNC=9874|UniProtKB=Q9UJF2	Ras GTPase-activating protein nGAP	IGI	9877179	PubMed	PTHR10194:SF52	RAS GTPASE-ACTIVATING PROTEIN NGAP
P00044	Nicotinic acetylcholine receptor signaling pathway	P01089	VAChT	PANTR|Ensembl=ENSPTRG00000002490|UniProtKB=H2Q1W2	Uncharacterized protein	ISS	21863848	PubMed	PTHR23506:SF13	VESICULAR ACETYLCHOLINE TRANSPORTER
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00030	Hypoxia response via HIF activation	P00817	TOR	HUMAN|HGNC=10260|UniProtKB=P51449	Nuclear receptor ROR-gamma	IC			PTHR24082:SF196	NUCLEAR RECEPTOR ROR-GAMMA
P00059	p53 pathway	P04633	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=1561991|UniProtKB=A0A096MJW8	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF51	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	BOVIN|Gene=ACVR2B|UniProtKB=Q95126	Activin receptor type-2B	TAS	9395284	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P00057	Wnt signaling pathway	P01440	Cadherin	BOVIN|Ensembl=ENSBTAG00000012992|UniProtKB=Q3SWX5	Cadherin-6	ISS	8120095	PubMed	PTHR24027:SF322	CADHERIN-6
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9441|UniProtKB=P51817	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	DROME|FlyBase=FBgn0260964|UniProtKB=Q8IH57	GH10249p	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00021	FGF signaling pathway	P00629	PP2A	MOUSE|MGI=MGI=1321161|UniProtKB=P62715	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	BACSU|EnsemblGenome=BSU38830|UniProtKB=P94358	Uncharacterized aldehyde dehydrogenase AldY	IC			PTHR42986:SF1	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	TAS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01148	Grb2	BOVIN|Ensembl=ENSBTAG00000004736|UniProtKB=Q3T0F9	Growth factor receptor-bound protein 2	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	HUMAN|HGNC=143|UniProtKB=P68032	Actin, alpha cardiac muscle 1	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00004	Alzheimer disease-presenilin pathway	P00141	Membrane metalloprotease	PANTR|Ensembl=ENSPTRG00000006148|UniProtKB=H2Q7Z4	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF24	MATRIX METALLOPROTEINASE-14
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IPI	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00025	Hedgehog signaling pathway	P00682	PKA	STRPU|EnsemblGenome=SPU_018419|UniProtKB=W4YRI6	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000013587|UniProtKB=F7AZ16	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF33	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-3
P00012	Cadherin signaling pathway	P00470	F-actin	XENTR|Xenbase=XB-GENE-491938|UniProtKB=Q6DIV8	Actin, alpha 1, skeletal muscle	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P02775	Salvage pyrimidine ribonucleotides	P03149	Cytidine kinase	MONDO|Ensembl=ENSMODG00000001349|UniProtKB=F7FW97	Uridine-cytidine kinase	ISS			PTHR10285:SF70	URIDINE-CYTIDINE KINASE 2
P00052	TGF-beta signaling pathway	P01275	P38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	TAS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000013084|UniProtKB=F7H390	Uncharacterized protein	ISS	12181435	PubMed	PTHR24247:SF108	5-HYDROXYTRYPTAMINE RECEPTOR 5A
P06664	Gonadotropin-releasing hormone receptor pathway	P06812	L-type Ca2+	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	RCA	15737619	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	RAT|RGD=3425|UniProtKB=P97887	Presenilin-1	IDA	12736250	PubMed	PTHR10202:SF18	PRESENILIN-1
P00018	EGF receptor signaling pathway	P00552	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00057	Wnt signaling pathway	P01443	Phospholipase C	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	8687404	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00036	Interleukin signaling pathway	P00990	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01131	MKP5	HUMAN|HGNC=3067|UniProtKB=Q9UNI6	Dual specificity protein phosphatase 12	TAS			PTHR10159:SF293	DUAL SPECIFICITY PROTEIN PHOSPHATASE 12
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	6264430	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	MOUSE|MGI=MGI=99673|UniProtKB=P84309	Adenylate cyclase type 5	ISS	94139935	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01161	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01315	Calcineurin	MACMU|Ensembl=ENSMMUG00000015714|UniProtKB=F6SFE0	Serine/threonine-protein phosphatase	ISS	12091710	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	IPI	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00049	Parkinson disease	P01208	Hsp70	ENTHI|EnsemblGenome=EHI_052860|UniProtKB=C4M3S5	Heat shock protein 70, putative	IDA	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P02738	De novo purine biosynthesis	P02891	GDP kinase	HUMAN|HGNC=20567|UniProtKB=O75414	Nucleoside diphosphate kinase 6	ISS			PTHR11349:SF70	NUCLEOSIDE DIPHOSPHATE KINASE 6
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	8787761	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00020	FAS signaling pathway	P00610	MKK4	PANTR|Ensembl=ENSPTRG00000008783|UniProtKB=H2QCA7	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CHICK|Ensembl=ENSGALG00000017178|UniProtKB=F1N982	Uncharacterized protein	ISS	12497607	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00049	Parkinson disease	P01238	14-3-3	ARATH|TAIR=AT1G22300|UniProtKB=P48347	14-3-3-like protein GF14 epsilon	IDA	10407019	PubMed	PTHR18860:SF32	14-3-3 FAMILY PROTEIN-RELATED
P00036	Interleukin signaling pathway	P00965	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00779	TBP	METJA|EnsemblGenome=MJ_0507|UniProtKB=Q57930	TATA-box-binding protein	IPI	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00047	PDGF signaling pathway	P01142	p90RSK	CANLF|Ensembl=ENSCAFG00000013171|UniProtKB=E2RP04	Uncharacterized protein	ISS	10558991	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	RAT|RGD=628596|UniProtKB=P69897	Tubulin beta-5 chain	ISS	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01324	rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	TAS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00048	PI3 kinase pathway	P01179	PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	IC	9199552	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00049	Parkinson disease	P01227	20S proteasome	DROME|FlyBase=FBgn0250746|UniProtKB=Q9VNA5	Proteasome subunit beta type-4	TAS	12859888	PubMed	PTHR11599:SF5	PROTEASOME SUBUNIT BETA TYPE-4
P00022	General transcription by RNA polymerase I	P00657	TBP	ENTHI|Gene=EHI_112050|UniProtKB=C4M7H7	TATA-box-binding protein 2	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P06212	DPP-SCW signaling pathway	P06259	SCW	DROME|FlyBase=FBgn0005590|UniProtKB=P54631	Protein screw	IEA	7958918	PubMed	PTHR11848:SF54	PROTEIN 60A-RELATED
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	MACMU|Ensembl=ENSMMUG00000006620|UniProtKB=F7H481	Uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF157	CASEIN KINASE I ISOFORM GAMMA-2
P06664	Gonadotropin-releasing hormone receptor pathway	P06766	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	RCA	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00046	Oxidative stress response	P01131	MKP5	DROME|FlyBase=FBgn0031044|UniProtKB=Q9VWF4	LD31102p	ISS			PTHR10159:SF418	LD31102P
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04380	Cortocotropin releasing factor receptor signaling pathway	P04451	CRHR1	XENTR|Xenbase=XB-GENE-968267|UniProtKB=F6PTV6	Uncharacterized protein	ISS	11145609	PubMed	PTHR12011:SF175	CORTICOTROPIN-RELEASING FACTOR RECEPTOR 1
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04393	Ras Pathway	P04569	Cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00053	T cell activation	P01311	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IDA	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00628	JNK1-3	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00249	PAK	HUMAN|HGNC=8591|UniProtKB=Q13177	Serine/threonine-protein kinase PAK 2	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	DROME|FlyBase=FBgn0003861|UniProtKB=P19334	Transient receptor potential protein	IDA	11055438	PubMed	PTHR10117:SF51	TRANSIENT RECEPTOR POTENTIAL PROTEIN
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02753	Methionine biosynthesis	P03024	Homocysteine transmethylase	BACSU|EnsemblGenome=BSU02410|UniProtKB=O31463	Homocysteine S-methyltransferase YbgG	ISS			PTHR21091:SF123	FI01821P
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00034	Integrin signalling pathway	P00951	Jnk	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01172	c-Myc	BOVIN|Ensembl=ENSBTAG00000030337|UniProtKB=Q2TBP7	C-Myc-binding protein	ISS	15094771	PubMed	PTHR13168:SF0	C-MYC-BINDING PROTEIN
P00006	Apoptosis signaling pathway	P00310	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00021	FGF signaling pathway	P00623	FGF	BOVIN|Gene=FGF2|UniProtKB=P03969	Fibroblast growth factor 2	ISS			PTHR11486:SF83	FIBROBLAST GROWTH FACTOR 2
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	TAS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	ISS	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IDA	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04398	p53 pathway feedback loops 2	P04666	cyclin A	BOVIN|Gene=CCNA2|UniProtKB=P30274	Cyclin-A2	ISS			PTHR10177:SF69	CYCLIN-A2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TAKRU|Ensembl=ENSTRUG00000014318|UniProtKB=H2UI49	Uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00018	EGF receptor signaling pathway	P00551	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IGI	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00986	eNOS	MACMU|Ensembl=ENSMMUG00000020437|UniProtKB=F6WEB2	Nitric oxide synthase	ISS	22462730	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000020100|UniProtKB=H2R0T2	Uncharacterized protein	ISS			PTHR24248:SF16	ALPHA-1A ADRENERGIC RECEPTOR
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00006	Apoptosis signaling pathway	P00318	PKCs	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IDA	10395542	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P04393	Ras Pathway	P04552	SOS	DROME|FlyBase=FBgn0001965|UniProtKB=P26675	Protein son of sevenless	ISS	8479536	PubMed	PTHR23113:SF99	PROTEIN SON OF SEVENLESS
P04395	Vasopressin synthesis	P04589	Signal Peptidase	SCHPO|PomBase=SPAC56F8.11|UniProtKB=Q10259	Probable microsomal signal peptidase subunit 3	IC	2092035	PubMed	PTHR12804:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05918	p38 MAPK pathway	P06031	p38alpha	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	RCA	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05918	p38 MAPK pathway	P06020	p38delta	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00060	Ubiquitin proteasome pathway	P01491	E2	ORYSJ|EnsemblGenome=OS02G0261100|UniProtKB=Q8S919	Ubiquitin-conjugating enzyme E2 5B	ISS			PTHR24068:SF65	UBIQUITIN-CONJUGATING ENZYME E2 10-RELATED
P00057	Wnt signaling pathway	P01465	Ggamma	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	PANTR|Ensembl=ENSPTRG00000010105|UniProtKB=H2QEP3	Suppressor of cytokine signaling 6	ISS	15032587	PubMed	PTHR44562:SF1	SUPPRESSOR OF CYTOKINE SIGNALING 6
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04397	p53 pathway by glucose deprivation	P04640	p53	HUMAN|HGNC=15979|UniProtKB=Q9H3D4	Tumor protein 63	TAS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BOVIN|Ensembl=ENSBTAG00000006495|UniProtKB=P11017	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00006	Apoptosis signaling pathway	P00313	IKK	RAT|RGD=621375|UniProtKB=Q9QY78	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00048	PI3 kinase pathway	P01179	PKB	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	TAS	98382502	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	DEIRA|EnsemblGenome=DR_2630|UniProtKB=Q9RR67	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00017	DNA replication	P00527	Histones	DROME|FlyBase=FBgn0004828|UniProtKB=P84249	Histone H3.3	ISS	12413958	PubMed	PTHR11426:SF179	HISTONE H3.3
P00019	Endothelin signaling pathway	P00586	Gq	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00059	p53 pathway	P01486	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	ARATH|TAIR=AT1G13890|UniProtKB=Q9LMG8	Putative SNAP25 homologous protein SNAP30	IC			PTHR19305:SF7	SNAP25 HOMOLOGOUS PROTEIN SNAP30-RELATED
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	HUMAN|HGNC=172|UniProtKB=P36896	Activin receptor type-1B	IDA			PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00269	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	IDA	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00021	FGF signaling pathway	P00636	FGFR1-4	ORNAN|Ensembl=ENSOANG00000003252|UniProtKB=F6SM70	Fibroblast growth factor receptor	ISS	2544996	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P00019	Endothelin signaling pathway	P00577	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	RAT|RGD=619966|UniProtKB=F1LQT1	Adenylate cyclase 7	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00029	Huntington disease	P00807	Actin	RAT|RGD=1304556|UniProtKB=P63259	Actin, cytoplasmic 2	ISS	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00021	FGF signaling pathway	P00628	JNK1-3	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00775	Rac	ARATH|TAIR=AT2G17800|UniProtKB=Q38902	Rac-like GTP-binding protein ARAC1	ISS			PTHR24072:SF179	RAC-LIKE GTP-BINDING PROTEIN ARAC1-RELATED
P00047	PDGF signaling pathway	P01154	Ras	TAKRU|Ensembl=ENSTRUG00000005329|UniProtKB=H2SK54	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00034	Integrin signalling pathway	P00906	Rap1	DROME|FlyBase=FBgn0004636|UniProtKB=P08645	Ras-like protein 3	IPI	8576107	PubMed	PTHR24070:SF263	RAS-LIKE PROTEIN 3
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	CANLF|Ensembl=ENSCAFG00000018144|UniProtKB=F1PNI3	Uncharacterized protein	ISS	6086339	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P06664	Gonadotropin-releasing hormone receptor pathway	P06830	AMPK	MOUSE|MGI=MGI=108079|UniProtKB=Q61112	45 kDa calcium-binding protein	RCA			PTHR10827:SF51	45 KDA CALCIUM-BINDING PROTEIN
P00047	PDGF signaling pathway	P01165	SRF	HUMAN|HGNC=11291|UniProtKB=P11831	Serum response factor	ISS	15326221	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00018	EGF receptor signaling pathway	P00551	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IGI	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	IC	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00019	Endothelin signaling pathway	P00568	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IDA	88234494	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00020	FAS signaling pathway	P00615	JNK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	TAS	7600581	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00206	Wnt	MACMU|Ensembl=ENSMMUG00000021725|UniProtKB=F7E738	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05917	Opioid proopiomelanocortin pathway	P06009	K+ channel	PANTR|Ensembl=ENSPTRG00000020614|UniProtKB=H2QWR7	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P02738	De novo purine biosynthesis	P02909	GDP reductase	DEIRA|EnsemblGenome=DR_B0109|UniProtKB=Q9RZL6	Ribonucleoside-diphosphate reductase, beta chain	ISS			PTHR23409:SF32	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT BETA
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	TAS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00005	Angiogenesis	P00245	Rac	PANTR|Ensembl=ENSPTRG00000003550|UniProtKB=H2Q3I0	Rho GTPase activating protein 1	ISS	14724572	PubMed	PTHR23176:SF28	RHO GTPASE-ACTIVATING PROTEIN 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	2837282	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=5292|UniProtKB=P30939	5-hydroxytryptamine receptor 1F	IDA	12181435	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IGI	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	MOUSE|MGI=MGI=107471|UniProtKB=P31695	Neurogenic locus notch homolog protein 4	IDA	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P00034	Integrin signalling pathway	P00944	Actin	MOUSE|MGI=MGI=87906|UniProtKB=P63260	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00046	Oxidative stress response	P01132	c-jun	XENTR|Xenbase=XB-GENE-482228|UniProtKB=F6RYL1	Uncharacterized protein	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00059	p53 pathway	P04630	PP2A	STRPU|EnsemblGenome=SPU_025182|UniProtKB=W4ZAK5	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04555	PDK	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00034	Integrin signalling pathway	P00912	Arp2/3	DROME|FlyBase=FBgn0032859|UniProtKB=Q9VIM5	Actin-related protein 2/3 complex subunit 2	IPI	12473693	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00054	Toll receptor signaling pathway	P01368	MKK2	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00015	Circadian clock system	G01503	per	HUMAN|HGNC=8845|UniProtKB=O15534	Period circadian protein homolog 1	IDA	12782655	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00627	ERK1-2	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00021	FGF signaling pathway	P00636	FGFR1-4	CANLF|Ensembl=ENSCAFG00000005970|UniProtKB=E2R186	Fibroblast growth factor receptor	ISS	2544996	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	XENTR|Xenbase=XB-GENE-490883|UniProtKB=Q6NVA9	Actin, cytoplasmic 1	ISS	11889139	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DANRE|ZFIN=ZDB-GENE-040426-1354|UniProtKB=Q7T2C5	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	DANRE|ZFIN=ZDB-GENE-020419-19|UniProtKB=Q8JHE0	Casein kinase 1-alphaLS	ISS	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00056	VEGF signaling pathway	P01407	Erk	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	HUMAN|HGNC=1736|UniProtKB=P60953	Cell division control protein 42 homolog	ISS	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	RAT|RGD=2027|UniProtKB=P63269	Actin, gamma-enteric smooth muscle	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00001	Adrenaline and noradrenaline biosynthesis	P00062	TH	MACMU|Ensembl=ENSMMUG00000003912|UniProtKB=F6ZV38	Uncharacterized protein	ISS	191290	OMIM	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00006	Apoptosis signaling pathway	P00310	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00029	Huntington disease	P00780	Microtubule	STRPU|EnsemblGenome=SPU_013273|UniProtKB=W4YBZ7	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00045	Notch signaling pathway	P01112	CoR	CAEEL|WormBase=WBGene00018892|UniProtKB=G5EBE3	CIR (Transcription factor CBF1 Interacting coRepressor) homolog	TAS	11112321	PubMed	PTHR13151:SF2	COREPRESSOR INTERACTING WITH RBPJ 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008422|UniProtKB=F6VUT7	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00193	SOS-1	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00012	Cadherin signaling pathway	P00475	Frizzled	BOVIN|Ensembl=ENSBTAG00000002107|UniProtKB=A7MB15	FZD1 protein	ISS	12549854	PubMed	PTHR11309:SF81	FRIZZLED-1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	2372396	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00644	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00019	Endothelin signaling pathway	P00580	ET-RA/B	RAT|RGD=2535|UniProtKB=P26684	Endothelin-1 receptor	IPI	12538737	PubMed	PTHR24243:SF31	ENDOTHELIN-1 RECEPTOR
P02783	Tryptophan biosynthesis	P03209	Anthranilate phosphoribosyl transferase	LEPIN|EnsemblGenome=LA_1140|UniProtKB=Q8F708	Anthranilate phosphoribosyltransferase	ISS			PTHR43285:SF2	ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	CHICK|Ensembl=ENSGALG00000009320|UniProtKB=Q4JIM4	Presenilin-1	TAS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00049	Parkinson disease	P01239	Cul-1	MOUSE|MGI=MGI=1349658|UniProtKB=Q9WTX6	Cullin-1	IDA	12628165	PubMed	PTHR11932:SF81	CULLIN-1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DANRE|ZFIN=ZDB-GENE-030131-55|UniProtKB=Q6XNL8	Actin	IEP	11889126	PubMed	PTHR11937:SF263	ACTIN
P00030	Hypoxia response via HIF activation	P00823	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	THEMA|EnsemblGenome=TM_1698|UniProtKB=Q9X224	Aspartate aminotransferase	ISS			PTHR43795:SF5	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CAEEL|WormBase=WBGene00004036|UniProtKB=G5EFI8	Phosphoinositide phospholipase C	TAS			PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00018	EGF receptor signaling pathway	P00564	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	IGI	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P02779	Thiamin biosynthesis	P03175	1-Deoxyxylulose-5-phosphate synthase	ARATH|TAIR=AT3G21500|UniProtKB=F4IXL8	1-deoxy-D-xylulose 5-phosphate synthase 1	ISS			PTHR43322:SF5	1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE 1-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01168	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CAEBR|Gene=CBG23091|UniProtKB=A8Y4Q9	Protein CBR-ACT-2	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CHICK|Ensembl=ENSGALG00000004083|UniProtKB=Q90855	AMPA receptor GluR1/A	ISS	12941441	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00053	T cell activation	P01320	PLC-gamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00006	Apoptosis signaling pathway	P00292	IkappaB	PANTR|Ensembl=ENSPTRG00000006265|UniProtKB=H2Q867	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	ISS	14665694	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P05918	p38 MAPK pathway	P06031	p38alpha	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	ISS	10995439	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00006	Apoptosis signaling pathway	P00292	IkappaB	RAT|RGD=3171|UniProtKB=Q63746	NF-kappa-B inhibitor alpha	ISS	10811867	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P06664	Gonadotropin-releasing hormone receptor pathway	P06794	MAP2K1/2	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	RCA	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00057	Wnt signaling pathway	P01446	Calcineurin	MOUSE|MGI=MGI=107163|UniProtKB=P48453	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	IDA	7532676	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	G01581	BAX	MACMU|Ensembl=ENSMMUG00000003907|UniProtKB=F6ZV96	Apoptosis regulator BAX isoform alpha	ISS	14963330	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00049	Parkinson disease	P01212	p38 MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000022000|UniProtKB=Q9MZL5	Voltage-dependent L-type calcium channel subunit beta-2	IC	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00053	T cell activation	P01324	rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12960248	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	MACMU|Ensembl=ENSMMUG00000010678|UniProtKB=F7AXI7	Uncharacterized protein	ISS	9756087	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00048	PI3 kinase pathway	P01177	P110ACT	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00029	Huntington disease	P00786	ARF	DANRE|ZFIN=ZDB-GENE-040426-2382|UniProtKB=Q6P5M7	ADP-ribosylation factor-like 4Cb	ISS	12932731	PubMed	PTHR11711:SF119	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 4C
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	ISS	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P05913	Enkephalin release	P05976	Enkephalin	RAT|RGD=68946|UniProtKB=P04094	Proenkephalin-A	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00021	FGF signaling pathway	P00645	Rac	DROME|FlyBase=FBgn0039532|UniProtKB=Q7JWS8	AT17867p	ISS			PTHR24072:SF157	AT17867P
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	10693759	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	IDA	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00557	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CHICK|Ensembl=ENSGALG00000009621|UniProtKB=P60706	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	HUMAN|HGNC=1070|UniProtKB=P12645	Bone morphogenetic protein 3	TAS	9759503	PubMed	PTHR11848:SF144	BONE MORPHOGENETIC PROTEIN 3
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	CIOIN|Ensembl=ENSCING00000009515|UniProtKB=Q8T3S5	Casein kinase 2 alpha subunit	IDA	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01465	Ggamma	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00019	Endothelin signaling pathway	P00587	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00030	Hypoxia response via HIF activation	P00814	P300	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	IDA	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00014	Cholesterol biosynthesis	P00498	Hydroxymethyl glutaryl CoA synthase	RAT|RGD=70970|UniProtKB=P17425	Hydroxymethylglutaryl-CoA synthase, cytoplasmic	ISS	600234	OMIM	PTHR43323:SF4	HYDROXYMETHYLGLUTARYL-COA SYNTHASE, CYTOPLASMIC
P00035	Interferon-gamma signaling pathway	P00956	SOCS	PANTR|Ensembl=ENSPTRG00000014967|UniProtKB=H2RGD4	Uncharacterized protein	ISS	15032587	PubMed	PTHR44649:SF1	CYTOKINE-INDUCIBLE SH2-CONTAINING PROTEIN
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00474	Wnt	CAEEL|WormBase=WBGene00003395|UniProtKB=Q10459	Protein mom-2	ISS	8717036	PubMed	PTHR12027:SF3	PROTEIN MOM-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01211	ERK	CANLF|Ensembl=ENSCAFG00000018202|UniProtKB=E2RPJ2	Mitogen-activated protein kinase	ISS	12912994	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00796	Kainate receptor	CANLF|Ensembl=ENSCAFG00000003333|UniProtKB=F1PWT6	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00010	B cell activation	P00367	NFAT	PANTR|Ensembl=ENSPTRG00000006218|UniProtKB=H2Q834	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00019	Endothelin signaling pathway	P00586	Gq	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00029	Huntington disease	P00780	Microtubule	DANRE|ZFIN=ZDB-GENE-040426-2879|UniProtKB=Q6IQJ2	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00018	EGF receptor signaling pathway	P00555	MKK4,7	CANLF|Ensembl=ENSCAFG00000017851|UniProtKB=F1PBB6	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00046	Oxidative stress response	P01129	JNK1/2	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P05918	p38 MAPK pathway	P06021	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	14564011	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00045	Notch signaling pathway	P01105	TACE	PANTR|Ensembl=ENSPTRG00000011640|UniProtKB=H2R900	Uncharacterized protein	ISS	12834808	PubMed	PTHR11905:SF171	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	ISS	9166716	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00018	EGF receptor signaling pathway	P00542	EGFR	PANTR|Ensembl=ENSPTRG00000012883|UniProtKB=H2QJC5	Receptor protein-tyrosine kinase	ISS	4884676	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00049	Parkinson disease	P01242	Casein kinase I	CANLF|Ensembl=ENSCAFG00000006059|UniProtKB=F1Q126	Uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000012778|UniProtKB=H2QJ75	Phosphoinositide phospholipase C	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	88241036	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00049	Parkinson disease	P01227	20S proteasome	LEIMA|EnsemblGenome=LmjF.21.1700|UniProtKB=Q4QC13	Proteasome subunit alpha type	TAS	12859888	PubMed	PTHR11599:SF16	PROTEASOME SUBUNIT ALPHA TYPE-2
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95815|UniProtKB=P39087	Glutamate receptor ionotropic, kainate 2	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	PANTR|Ensembl=ENSPTRG00000004701|UniProtKB=H2Q5G9	Low density lipoprotein receptor-related protein 6	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P02738	De novo purine biosynthesis	P02898	Phosphoribosylformylglycinamide  synthase	HUMAN|HGNC=8863|UniProtKB=O15067	Phosphoribosylformylglycinamidine synthase	ISS			PTHR10099:SF1	PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE
P00047	PDGF signaling pathway	P01169	Vav	CHICK|Ensembl=ENSGALG00000002699|UniProtKB=F1NG51	Uncharacterized protein	ISS	14623913	PubMed	PTHR22826:SF95	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	BRAFL|Gene=BRAFLDRAFT_87235|UniProtKB=C3ZEV9	Putative uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF245	AT16150P-RELATED
P06959	CCKR signaling map	P07091	PAK	HUMAN|HGNC=8590|UniProtKB=Q13153	Serine/threonine-protein kinase PAK 1	RCA	12551923	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00006	Apoptosis signaling pathway	P00311	GCKR	BOVIN|Ensembl=ENSBTAG00000016442|UniProtKB=E1BJH5	Mitogen-activated protein kinase kinase kinase kinase	ISS			PTHR24361:SF205	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 3
P00018	EGF receptor signaling pathway	P00547	PP2A	MACMU|Ensembl=ENSMMUG00000020819|UniProtKB=F7HSM1	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00055	Transcription regulation by bZIP transcription factor	P01398	TFIIEalpha	RAT|RGD=1306851|UniProtKB=G3V992	General transcription factor II E, polypeptide 1 (Alpha subunit)	ISS	92065982	PubMed	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	ORNAN|Ensembl=ENSOANG00000015652|UniProtKB=F7FY70	Uncharacterized protein	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00029	Huntington disease	P00774	Dynein complex	MONDO|Ensembl=ENSMODG00000003133|UniProtKB=F6WUZ7	Uncharacterized protein	ISS	9454836	PubMed	PTHR11886:SF52	DYNEIN LIGHT CHAIN 1, CYTOPLASMIC
P06959	CCKR signaling map	G07296	IL8	HUMAN|HGNC=6025|UniProtKB=P10145	Interleukin-8	RCA	18395088	PubMed	PTHR10179:SF70	INTERLEUKIN-8
P00029	Huntington disease	P00769	N-Wasp	MOUSE|MGI=MGI=1920428|UniProtKB=Q91YD9	Neural Wiskott-Aldrich syndrome protein	TAS	12932731	PubMed	PTHR23202:SF39	NEURAL WISKOTT-ALDRICH SYNDROME PROTEIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	HUMAN|HGNC=9508|UniProtKB=P49768	Presenilin-1	IDA	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00029	Huntington disease	P00780	Microtubule	CAEEL|WormBase=WBGene00000248|UniProtKB=Q18817	Uncharacterized protein	IDA	12932731	PubMed	PTHR11588:SF120	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00947	Laminin	ANOGA|EnsemblGenome=AGAP007629|UniProtKB=Q7QJR9	AGAP007629-PA	IPI	2538453	PubMed	PTHR10574:SF79	LAMININ SUBUNIT GAMMA-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00006	Apoptosis signaling pathway	P00271	Bax	HUMAN|HGNC=959|UniProtKB=Q07812	Apoptosis regulator BAX	ISS	11099028	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04393	Ras Pathway	P04570	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01142	p90RSK	HUMAN|HGNC=10437|UniProtKB=Q9UBS0	Ribosomal protein S6 kinase beta-2	ISS	6755374	gi	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00047	PDGF signaling pathway	P01143	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00368	vav	HUMAN|HGNC=12657|UniProtKB=P15498	Proto-oncogene vav	IGI	14623913	PubMed	PTHR22826:SF112	PROTO-ONCOGENE VAV
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS	97236778	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00049	Parkinson disease	P01211	ERK	CANLF|Ensembl=ENSCAFG00000018202|UniProtKB=E2RPJ2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00047	PDGF signaling pathway	P01154	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00030	Hypoxia response via HIF activation	P00819	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00828	Galphai	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	RCA			PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00038	JAK/STAT signaling pathway	P01027	STAT	MOUSE|MGI=MGI=103038|UniProtKB=P42227	Signal transducer and activator of transcription 3	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00012	Cadherin signaling pathway	P00462	Casein kinase II	IXOSC|EnsemblGenome=ISCW014459|UniProtKB=B7QIS2	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P05731	GABA-B receptor II signaling	P05752	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	RCA	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00059	p53 pathway	P01486	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IDA	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	IC	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00059	p53 pathway	P01485	p53	RAT|RGD=3889|UniProtKB=P10361	Cellular tumor antigen p53	TAS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	MONDO|Ensembl=ENSMODG00000013970|UniProtKB=F6R6X5	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00054	Toll receptor signaling pathway	P01360	IKKbeta	MOUSE|MGI=MGI=1338071|UniProtKB=O88351	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00049	Parkinson disease	P01227	20S proteasome	RAT|RGD=61851|UniProtKB=P48004	Proteasome subunit alpha type-7	TAS	12859888	PubMed	PTHR11599:SF40	PROTEASOME SUBUNIT ALPHA TYPE-7
P00029	Huntington disease	P00786	ARF	CHLRE|EnsemblGenome=CHLREDRAFT_186126|UniProtKB=A8IL29	Small ARF-related GTPase	IPI	11752622	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00010	B cell activation	P00379	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=1562864|UniProtKB=D4A497	Protein Pcdh11x	ISS	8120095	PubMed	PTHR43912:SF1	PROTOCADHERIN-11 X-LINKED-RELATED
P00056	VEGF signaling pathway	P01421	Rac	DROME|FlyBase=FBgn0036257|UniProtKB=Q9VTU3	Rho GTPase-activating protein 68F	ISS			PTHR23176:SF0	RHO GTPASE-ACTIVATING PROTEIN 68F
P00020	FAS signaling pathway	P00610	MKK4	CANLF|Ensembl=ENSCAFG00000017851|UniProtKB=F1PBB6	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00049	Parkinson disease	P01219	SAPK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	NAS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	DANRE|ZFIN=ZDB-GENE-980605-30|UniProtKB=Q9YHE8	Transcription factor 7-like 1-A	TAS	11266476	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000004742|UniProtKB=H2Q5K1	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P00012	Cadherin signaling pathway	P00470	F-actin	CAEEL|WormBase=WBGene00000066|UniProtKB=P10986	Actin-4	IC	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	CANLF|Ensembl=ENSCAFG00000017516|UniProtKB=E2REK6	Uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF311	CALMODULIN
P05918	p38 MAPK pathway	P06031	p38alpha	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00056	VEGF signaling pathway	P01410	Caspase9	HUMAN|HGNC=1511|UniProtKB=P55211	Caspase-9	IDA	9390557	PubMed	PTHR10454:SF157	CASPASE-9
P00052	TGF-beta signaling pathway	P01284	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02772	Pyruvate metabolism	P03133	Pyruvate Dehydrogenase	MYCTU|EnsemblGenome=LH57_04605|UniProtKB=I6XWE5	Dehydrogenase	ISS	9634230	PubMed	PTHR11516:SF41	SUBFAMILY NOT NAMED
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	RAT|RGD=2088|UniProtKB=P11883	Aldehyde dehydrogenase, dimeric NADP-preferring	IC	14724059	PubMed	PTHR43570:SF15	ALDEHYDE DEHYDROGENASE, DIMERIC NADP-PREFERRING
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00017	DNA replication	P00534	PCNA	MACMU|Ensembl=ENSMMUG00000013259|UniProtKB=F6ZD63	Proliferating cell nuclear antigen	ISS	12893285	PubMed	PTHR11352:SF0	PROLIFERATING CELL NUCLEAR ANTIGEN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00029	Huntington disease	P00805	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01154	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00021	FGF signaling pathway	P00624	14-3-3	XENTR|Xenbase=XB-GENE-951350|UniProtKB=Q0V9W8	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	ISS	9507245	gi	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00053	T cell activation	P01295	vav	CHICK|Ensembl=ENSGALG00000001915|UniProtKB=R4GI39	Uncharacterized protein	IDA	14623913	PubMed	PTHR22826:SF97	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01080	AChE	CAEEL|WormBase=WBGene00000036|UniProtKB=G5EDV9	Carboxylic ester hydrolase	IC			PTHR43918:SF6	CARBOXYLIC ESTER HYDROLASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CANLF|Ensembl=ENSCAFG00000032542|UniProtKB=J9P639	Uncharacterized protein	ISS	11259487	PubMed	PTHR24229:SF1	KAPPA-TYPE OPIOID RECEPTOR
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P02742	Tetrahydrofolate biosynthesis	P02944	Phosphoribosylglycinamide formyltransferase	ARATH|TAIR=AT1G31220|UniProtKB=P52422	Phosphoribosylglycinamide formyltransferase, chloroplastic	ISS			PTHR43369:SF2	PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MACMU|Ensembl=ENSMMUG00000002263|UniProtKB=F6VEE0	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MOUSE|MGI=MGI=101848|UniProtKB=P62881	Guanine nucleotide-binding protein subunit beta-5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00052	TGF-beta signaling pathway	P01284	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MACMU|Ensembl=ENSMMUG00000011466|UniProtKB=F7B2R8	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	IDA	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DANRE|ZFIN=ZDB-GENE-041001-104|UniProtKB=Q5TZD4	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	97449291	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	8838325	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00029	Huntington disease	P00790	beta-Tubulin	HUMAN|HGNC=20771|UniProtKB=P68371	Tubulin beta-4B chain	TAS	9454836	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P02752	Mannose metabolism	P03019	P-Mannose mutase	BOVIN|Ensembl=ENSBTAG00000001440|UniProtKB=Q3SZJ9	Phosphomannomutase 2	ISS	12477932	PubMed	PTHR10466:SF2	PHOSPHOMANNOMUTASE 2
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	8170357	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	MONDO|Ensembl=ENSMODG00000018237|UniProtKB=F6PG65	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00010	B cell activation	P00375	Calmodulin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g239788|UniProtKB=A7RPI8	Predicted protein	ISS			PTHR23050:SF245	AT16150P-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00029	Huntington disease	P00779	TBP	ARATH|TAIR=AT1G55520|UniProtKB=P28148	TATA-box-binding protein 2	IPI	600075	OMIM	PTHR10126:SF36	TATA-BOX-BINDING PROTEIN 1-RELATED
P00005	Angiogenesis	P00224	PDGF	CANLF|Ensembl=ENSCAFG00000008612|UniProtKB=F1PGJ9	Uncharacterized protein	ISS			PTHR11633:SF5	PLATELET-DERIVED GROWTH FACTOR C
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	TAS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	HUMAN|HGNC=9441|UniProtKB=P51817	cAMP-dependent protein kinase catalytic subunit PRKX	IC	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00006	Apoptosis signaling pathway	P00296	DAXX	MACMU|Ensembl=ENSMMUG00000004287|UniProtKB=F6ZLZ0	Uncharacterized protein	ISS	9215629	PubMed	PTHR12766:SF7	DEATH DOMAIN-ASSOCIATED PROTEIN 6
P04393	Ras Pathway	P04570	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P05913	Enkephalin release	P05978	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00036	Interleukin signaling pathway	P00987	SRF	PANTR|Ensembl=ENSPTRG00000018189|UniProtKB=H2QT21	Uncharacterized protein	ISS	15326221	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	TAKRU|Ensembl=ENSTRUG00000011297|UniProtKB=H2TV18	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00053	T cell activation	P01311	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P06959	CCKR signaling map	P07090	MAPK8-10	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	RCA	12193476	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00020	FAS signaling pathway	P00601	c-Jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	HUMAN|HGNC=9508|UniProtKB=P49768	Presenilin-1	TAS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00036	Interleukin signaling pathway	P00965	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	DANRE|ZFIN=ZDB-GENE-000330-9|UniProtKB=Q90ZE4	Presenilin-2	TAS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00053	T cell activation	P01320	PLC-gamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P05913	Enkephalin release	P05974	G-Protein (i)	ORNAN|Ensembl=ENSOANG00000003489|UniProtKB=F7FSE3	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00254	GTPase	MONDO|Ensembl=ENSMODG00000000981|UniProtKB=F7ES59	Uncharacterized protein	ISS	12090470	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	MACMU|Ensembl=ENSMMUG00000018375|UniProtKB=F7H1D5	Neurogenic locus notch homolog protein 2 isoform 1 preproprotein	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	RAT|RGD=3381|UniProtKB=P62716	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P02749	Leucine biosynthesis	P03002	Isopropylmalate isomerase	PSEAE|EnsemblGenome=PA3121|UniProtKB=Q9HZA3	3-isopropylmalate dehydratase large subunit	ISS			PTHR43822:SF2	HOMOACONITASE, MITOCHONDRIAL
P00056	VEGF signaling pathway	P01407	Erk	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00556	PLCgamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00037	Ionotropic glutamate receptor pathway	P01020	NSF	TRYB2|Gene=TB927.1.1560|UniProtKB=Q4GZ63	Vesicular-fusion protein NsF, putative N-ethylmaleimide sensitive factor (NsF)	ISS	11348590	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	SCHPO|PomBase=SPBC32H8.07|UniProtKB=Q10282	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04393	Ras Pathway	P04559	Rac	MACMU|Ensembl=ENSMMUG00000010895|UniProtKB=F7FSK9	Uncharacterized protein	ISS	15470041	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	TAS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P02770	Pyridoxal phosphate salvage pathway	P03121	Pyridoxal kinase	BOVIN|Ensembl=ENSBTAG00000018186|UniProtKB=Q0II59	Pyridoxal kinase	ISS	10395444	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P00019	Endothelin signaling pathway	P00577	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	14505573	PubMed	PTHR10048:SF14	PI-3 KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008422|UniProtKB=F6VUT7	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	PANTR|Ensembl=ENSPTRG00000007537|UniProtKB=H2R1H5	Uncharacterized protein	ISS	9554852	PubMed	PTHR10845:SF11	AXIN-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05731	GABA-B receptor II signaling	P05755	Gbeta	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	9754712	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IDA	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00563	Gab	BOVIN|Ensembl=ENSBTAG00000002922|UniProtKB=F1MFX6	Uncharacterized protein	ISS	15356145	PubMed	PTHR12156:SF4	GRB2-ASSOCIATED-BINDING PROTEIN 2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04371	5-Hydroxytryptamine biosynthesis	P04399	Tryptophan hydroxylase	CHICK|Ensembl=ENSGALG00000006236|UniProtKB=P70080	Tryptophan 5-hydroxylase 1	ISS	14597720	PubMed	PTHR11473:SF23	TRYPTOPHAN 5-HYDROXYLASE 1
P00029	Huntington disease	P00807	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g242065|UniProtKB=A7S0V7	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00021	FGF signaling pathway	P00630	RKIP	DROME|FlyBase=FBgn0037431|UniProtKB=Q9I7L3	Uncharacterized protein	ISS			PTHR11362:SF28	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	TAS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MACMU|Ensembl=ENSMMUG00000014307|UniProtKB=A1C2U6	Growth/differentiation factor 8	ISS	9759503	PubMed	PTHR11848:SF150	GROWTH/DIFFERENTIATION FACTOR 8
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04393	Ras Pathway	P04557	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05734	Synaptic vesicle trafficking	P05777	Synaptophysin	CANLF|Ensembl=ENSCAFG00000015805|UniProtKB=F1Q4G9	Uncharacterized protein	ISS	313475	OMIM	PTHR10306:SF10	SYNAPTOPHYSIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P02771	Pyrimidine Metabolism	P03126	Nucleoside Phosphorylase	BACSU|EnsemblGenome=BSU39400|UniProtKB=P39142	Pyrimidine-nucleoside phosphorylase	ISS	10567266	PubMed	PTHR10515:SF0	THYMIDINE PHOSPHORYLASE
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	IPI	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00004	Alzheimer disease-presenilin pathway	P00127	APP	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04398	p53 pathway feedback loops 2	P04668	p53	MOUSE|MGI=MGI=98834|UniProtKB=P02340	Cellular tumor antigen p53	TAS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00054	Toll receptor signaling pathway	P01375	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00054	Toll receptor signaling pathway	P01356	ERK2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05918	p38 MAPK pathway	P06021	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12912997	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00005	Angiogenesis	P00203	Erk	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=3784|UniProtKB=P61265	Syntaxin-1B	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IGI	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00059	p53 pathway	P04630	PP2A	XENTR|Xenbase=XB-GENE-957248|UniProtKB=Q6GLE6	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00641	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05730	Endogenous cannabinoid signaling	P05746	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P02752	Mannose metabolism	P03015	GDP-Mannose 4,6-dehydratase	BRADU|Gene=BAC50730|UniProtKB=Q89J19	GDP-mannose 4,6-dehydratase	ISS	12642192	gi	PTHR43715:SF1	GDP-MANNOSE 4,6 DEHYDRATASE
P00057	Wnt signaling pathway	P01465	Ggamma	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IDA	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	MONDO|Ensembl=ENSMODG00000018459|UniProtKB=F7CU42	Uncharacterized protein	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00034	Integrin signalling pathway	P00936	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01162	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00049	Parkinson disease	P01211	ERK	MOUSE|MGI=MGI=2652894|UniProtKB=Q80Y86	Mitogen-activated protein kinase 15	ISS	12787066	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00034	Integrin signalling pathway	P00925	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05912	Dopamine receptor mediated signaling pathway	P05963	MAO	PANTR|Ensembl=ENSPTRG00000021817|UniProtKB=H2QYH6	Amine oxidase [flavin-containing]	ISS	8602220	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	TAS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00030	Hypoxia response via HIF activation	P00819	AKT	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	TAS	12089061	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	PANTR|Ensembl=ENSPTRG00000006148|UniProtKB=H2Q7Z4	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF24	MATRIX METALLOPROTEINASE-14
P00049	Parkinson disease	P01211	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05915	Opioid proenkephalin pathway	P05988	peptide E	HUMAN|HGNC=8831|UniProtKB=P01210	Proenkephalin-A	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00001	Adrenaline and noradrenaline biosynthesis	P00066	DOPA decarb.	PANTR|Ensembl=ENSPTRG00000019189|UniProtKB=H2QUK8	Uncharacterized protein	ISS	90339966	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00053	T cell activation	P01300	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00944	Actin	HUMAN|HGNC=17780|UniProtKB=Q562R1	Beta-actin-like protein 2	IPI	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00020	FAS signaling pathway	P00603	Pro-Caspase9	RAT|RGD=61867|UniProtKB=Q9JHK1	Caspase	IGI	9390557	PubMed	PTHR10454:SF157	CASPASE-9
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00004	Alzheimer disease-presenilin pathway	P00144	Ire-1	PANTR|Ensembl=ENSPTRG00000007893|UniProtKB=H2QAS4	Uncharacterized protein	ISS	10619423	PubMed	PTHR13954:SF15	SERINE/THREONINE-PROTEIN KINASE/ENDORIBONUCLEASE IRE2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MONDO|Ensembl=ENSMODG00000012009|UniProtKB=F7AMI2	Uncharacterized protein	ISS	12181435	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P06959	CCKR signaling map	P07214	RAC1-GTP	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	RCA	18565785	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00049	Parkinson disease	P01215	Syntaxin	MONDO|Ensembl=ENSMODG00000017550|UniProtKB=F7E0Z1	Uncharacterized protein	ISS	10321247	PubMed	PTHR19957:SF90	SYNTAXIN-7
P00049	Parkinson disease	P01214	CHIP	HUMAN|HGNC=11427|UniProtKB=Q9UNE7	E3 ubiquitin-protein ligase CHIP	IDA	12150907	PubMed	PTHR44284:SF1	E3 UBIQUITIN-PROTEIN LIGASE CHIP
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	MOUSE|MGI=MGI=97356|UniProtKB=Q01768	Nucleoside diphosphate kinase B	ISS			PTHR11349:SF57	NUCLEOSIDE DIPHOSPHATE KINASE B
P02787	Vitamin B6 metabolism	P03244	Pyridoxal kinase	PSEAE|EnsemblGenome=PA5516|UniProtKB=Q9HT57	Pyridoxal kinase PdxY	ISS	10984043	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IPI	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00552	Ras	YEAST|SGD=S000005042|UniProtKB=P01120	Ras-like protein 2	ISS	7997267	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	IXOSC|EnsemblGenome=ISCW003614|UniProtKB=B7PHY7	Cdc42 protein, putative	ISS	9658176	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00012	Cadherin signaling pathway	P00470	F-actin	DICDI|dictyBase=DDB_G0289811|UniProtKB=Q54GX7	Actin-10	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00059	p53 pathway	P04618	PML	PANTR|Ensembl=ENSPTRG00000007266|UniProtKB=Q15JE1	Promyelocytic leukemia	ISS	12810724	PubMed	PTHR45211:SF1	PROTEIN PML
P00056	VEGF signaling pathway	P01413	PI3K	XENTR|Xenbase=XB-GENE-6067221|UniProtKB=F6Z0J4	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00011	Blood coagulation	P00408	Plasminogen	HUMAN|HGNC=9071|UniProtKB=P00747	Plasminogen	ISS	2318848	PubMed	PTHR24261:SF6	PLASMINOGEN
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	TAKRU|Ensembl=ENSTRUG00000011517|UniProtKB=H2TWL9	Uncharacterized protein (Fragment)	ISS	12871085	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04380	Cortocotropin releasing factor receptor signaling pathway	P04455	beta-endorphin	DANRE|ZFIN=ZDB-GENE-041014-294|UniProtKB=Q5SPP4	Uncharacterized protein	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P05913	Enkephalin release	P05972	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00029	Huntington disease	P00780	Microtubule	IXOSC|EnsemblGenome=ISCW017133|UniProtKB=B7PA92	Beta tubulin	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02723	Adenine and hypoxanthine salvage pathway	P02807	Deoxyadenosine deaminase	STRCO|EnsemblGenome=CAB42949|UniProtKB=Q9X7T2	Adenosine deaminase 2	ISS			PTHR11409:SF43	ADENOSINE DEAMINASE
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	CAEEL|WormBase=WBGene00006615|UniProtKB=Q8I6Y9	TRP (Transient receptor potential) channel family	IDA	11055438	PubMed	PTHR10117:SF54	TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN
P00057	Wnt signaling pathway	P01457	GBeta	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00010	B cell activation	P00383	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	CHICK|Ensembl=ENSGALG00000011621|UniProtKB=F1NVD2	Uncharacterized protein	ISS	13642251	gi	PTHR15071:SF17	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MONDO|Ensembl=ENSMODG00000008889|UniProtKB=F7BRY9	Serine/threonine-protein kinase receptor	ISS	11252892	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	MONDO|Ensembl=ENSMODG00000001524|UniProtKB=F7F413	S-adenosylmethionine synthase	ISS			PTHR11964:SF11	S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CANLF|Ensembl=ENSCAFG00000005662|UniProtKB=E2R907	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00049	Parkinson disease	P01207	PLD2	BOVIN|Gene=PLD2|UniProtKB=Q0V8L6	Phospholipase D2	ISS	12615079	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	P01449	Nemo-like Kinase	CHICK|Ensembl=ENSGALG00000005699|UniProtKB=F1N862	Mitogen-activated protein kinase	ISS	10683140	PubMed	PTHR24055:SF179	SERINE/THREONINE-PROTEIN KINASE NLK
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ASHGO|EnsemblGenome=AGOS_ABR222W|UniProtKB=Q75D00	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	IDA	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01457	GBeta	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04393	Ras Pathway	P04542	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01172	c-Myc	HUMAN|HGNC=7553|UniProtKB=P01106	Myc proto-oncogene protein	ISS	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00047	PDGF signaling pathway	P01171	PLCgamma	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P06959	CCKR signaling map	G07000	TAC1	HUMAN|HGNC=11517|UniProtKB=P20366	Protachykinin-1	RCA	20007404	PubMed	PTHR11250:SF3	PROTACHYKININ-1
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	MOUSE|MGI=MGI=109284|UniProtKB=Q61144	Presenilin-2	TAS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00008	Axon guidance mediated by Slit/Robo	P00352	DCC	CANLF|Ensembl=ENSCAFG00000000157|UniProtKB=F1PAZ4	Uncharacterized protein	ISS	8861902	PubMed	PTHR44146:SF3	NETRIN RECEPTOR DCC
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	ARATH|TAIR=AT4G34460|UniProtKB=P49177	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF48	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00226	Delta/Serrate	RAT|RGD=2937|UniProtKB=Q63722	Protein jagged-1	ISS	7697721	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00054	Toll receptor signaling pathway	P01369	MKK1	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	BOVIN|Ensembl=ENSBTAG00000037429|UniProtKB=F1MGM3	Uncharacterized protein	ISS	12441358	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P00010	B cell activation	P00371	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00983	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02725	Allantoin degradation	P02822	Allantoinase	YEAST|SGD=S000001466|UniProtKB=P32375	Allantoinase	ISS			PTHR43668:SF2	ALLANTOINASE
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P02728	Arginine biosynthesis	P02847	N-actetylornithine deacetylase	THEMA|EnsemblGenome=TM_1666|UniProtKB=Q9X1Z4	Acetylornithine deacetylase	ISS			PTHR43808:SF3	ACETYLORNITHINE DEACETYLASE
P00018	EGF receptor signaling pathway	P00545	JNK1-3	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IGI	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00050	Plasminogen activating cascade	P01243	uPA	PANTR|Ensembl=ENSPTRG00000002646|UniProtKB=H2Q245	Uncharacterized protein	ISS	137114	gi	PTHR24264:SF38	UROKINASE-TYPE PLASMINOGEN ACTIVATOR
P00025	Hedgehog signaling pathway	P00682	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02775	Salvage pyrimidine ribonucleotides	P03152	Uridine phosphorylase	MACMU|Ensembl=ENSMMUG00000007037|UniProtKB=F7F1M1	Uridine phosphorylase	ISS			PTHR43691:SF3	URIDINE PHOSPHORYLASE 1
P00051	TCA cycle	P01269	alphaketoglutarate Dehydrogenase	PANTR|Ensembl=ENSPTRG00000019149|UniProtKB=H2QUI7	Uncharacterized protein	ISS	12477932	PubMed	PTHR23152:SF7	2-OXOGLUTARATE DEHYDROGENASE, MITOCHONDRIAL
P05912	Dopamine receptor mediated signaling pathway	P05970	TH	TAKRU|Ensembl=ENSTRUG00000009267|UniProtKB=A0JGX6	Tyrosine 3-monooxygenase	ISS	12480184	PubMed	PTHR11473:SF34	TYROSINE HYDROXYLASE
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00757	beta-arrestin	BOVIN|Ensembl=ENSBTAG00000021480|UniProtKB=P08168	S-arrestin	IDA	10206946	PubMed	PTHR11792:SF15	S-ARRESTIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	RAT|RGD=69430|UniProtKB=P32851	Syntaxin-1A	ISS	1321498	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00059	p53 pathway	G04699	BAI-1	BOVIN|Ensembl=ENSBTAG00000006385|UniProtKB=G3X6K9	Uncharacterized protein	ISS	9393972	PubMed	PTHR12011:SF39	BRAIN-SPECIFIC ANGIOGENESIS INHIBITOR 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	BOVIN|Ensembl=ENSBTAG00000006101|UniProtKB=Q58DA0	26S proteasome non-ATPase regulatory subunit 4	ISS	13645506	gi	PTHR10223:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4
P04393	Ras Pathway	P04548	ATF2	CHICK|Ensembl=ENSGALG00000009287|UniProtKB=O93602	Cyclic AMP-dependent transcription factor ATF-2	IDA	9819389	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12874273	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MONDO|Ensembl=ENSMODG00000012546|UniProtKB=F6PM16	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00047	PDGF signaling pathway	P01170	PDGF	MOUSE|MGI=MGI=97527|UniProtKB=P20033	Platelet-derived growth factor subunit A	ISS			PTHR11633:SF3	PLATELET-DERIVED GROWTH FACTOR SUBUNIT A
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DROME|FlyBase=FBgn0011743|UniProtKB=P45891	Actin-like protein 53D	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	IDA	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00057	Wnt signaling pathway	P01457	GBeta	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IDA	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	PANTR|Ensembl=ENSPTRG00000016293|UniProtKB=H2QPW8	Serine/threonine-protein kinase receptor	ISS			PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05916	Opioid prodynorphin pathway	P06002	G-protein	DAPPU|EnsemblGenome=DAPPUDRAFT_206575|UniProtKB=E9FUX0	Guanine nucleotide binding protein, beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00010	B cell activation	P00379	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00010	B cell activation	P00371	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00646	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	14707121	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00057	Wnt signaling pathway	P01471	alpha-catenin	PANTR|Ensembl=ENSPTRG00000017291|UniProtKB=H2QRK9	Catenin (Cadherin-associated protein), alpha 1, 102kDa	ISS	9362521	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00047	PDGF signaling pathway	P01150	PKC	BOVIN|Ensembl=ENSBTAG00000021900|UniProtKB=F1MFK1	Uncharacterized protein	ISS	125549	gi	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000019524|UniProtKB=F7CX56	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF71	PROTOCADHERIN BETA-16
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00054	Toll receptor signaling pathway	P01352	p38	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	ISS	20451058	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00185	JAK1	HUMAN|HGNC=6190|UniProtKB=P23458	Tyrosine-protein kinase JAK1	IDA	9637709	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00010	B cell activation	P00367	NFAT	CANLF|Ensembl=ENSCAFG00000011625|UniProtKB=F1PDD9	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00036	Interleukin signaling pathway	P00976	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P06664	Gonadotropin-releasing hormone receptor pathway	P06807	gnai	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	RCA	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00632	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IC	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04398	p53 pathway feedback loops 2	P04661	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	12660731	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000009766|UniProtKB=F6TFL4	Uncharacterized protein	ISS	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00010	B cell activation	P00380	fos	PANTR|Ensembl=ENSPTRG00000006553|UniProtKB=A5A6H0	C-fos	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MACMU|Ensembl=ENSMMUG00000017683|UniProtKB=F6UA63	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000004896|UniProtKB=F7C2C6	Uncharacterized protein (Fragment)	ISS	8444355	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04393	Ras Pathway	P04578	Rho	TAKRU|Ensembl=ENSTRUG00000010942|UniProtKB=H2TSH5	Uncharacterized protein	ISS	10556059	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	G04671	proopiomelanocortin	XENTR|Xenbase=XB-GENE-483703|UniProtKB=Q5M8F2	Proopiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P04384	Gamma-aminobutyric acid synthesis	P04482	Glutamate decarboxylase	DROME|FlyBase=FBgn0000153|UniProtKB=Q24062	Black, isoform A	ISS			PTHR11999:SF101	BLACK, ISOFORM A
P02761	Pantothenate biosynthesis	P03067	3-methyl-2-oxobutanoate hydroxymethyltransferase	LEPIN|EnsemblGenome=LA_3958|UniProtKB=Q8EZ98	3-methyl-2-oxobutanoate hydroxymethyltransferase	ISS			PTHR20881:SF0	3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT3G45640|UniProtKB=Q39023	Mitogen-activated protein kinase 3	ISS	11707292	PubMed	PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00259	TNF	CANLF|Ensembl=ENSCAFG00000000517|UniProtKB=P51742	Tumor necrosis factor	ISS	11911478	PubMed	PTHR11471:SF23	TUMOR NECROSIS FACTOR
P00034	Integrin signalling pathway	P00906	Rap1	MONDO|Ensembl=ENSMODG00000007323|UniProtKB=F7EFD0	Uncharacterized protein	ISS	10476970	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04392	P53 pathway feedback loops 1	G04685	p73DeltaN	RAT|RGD=620863|UniProtKB=Q9JJP6	Tumor protein 63	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01457	GBeta	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	IDA	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00019	Endothelin signaling pathway	P00589	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01067	AChE	BRAFL|Gene=BRAFLDRAFT_116869|UniProtKB=C3ZD75	Carboxylic ester hydrolase	ISS	87080761	PubMed	PTHR11559:SF356	ACETYLCHOLINESTERASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00628	JNK1-3	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00048	PI3 kinase pathway	P01206	14-3-3	ORNAN|Ensembl=ENSOANG00000007305|UniProtKB=F6XW91	Uncharacterized protein	ISS	12861023	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TRYB2|Gene=Tb09.211.0620|UniProtKB=Q38E94	Actin A	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00572	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00059	p53 pathway	P04633	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	HUMAN|HGNC=4388|UniProtKB=P38405	Guanine nucleotide-binding protein G(olf) subunit alpha	IC			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00019	Endothelin signaling pathway	P00590	IP3 R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	TAS	12660731	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00010	B cell activation	P00376	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00018	EGF receptor signaling pathway	P00555	MKK4,7	CHICK|Ensembl=ENSGALG00000001001|UniProtKB=F1P3T1	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00006	Apoptosis signaling pathway	P00274	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	HUMAN|HGNC=11840|UniProtKB=Q04727	Transducin-like enhancer protein 4	IDA	9783586	PubMed	PTHR10814:SF21	TRANSDUCIN-LIKE ENHANCER PROTEIN 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02753	Methionine biosynthesis	P03024	Homocysteine transmethylase	MACMU|Ensembl=ENSMMUG00000010073|UniProtKB=F6T0P5	Uncharacterized protein	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00010	B cell activation	P00383	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IDA	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	TAKRU|Ensembl=ENSTRUG00000005329|UniProtKB=H2SK54	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P02781	Threonine biosynthesis	P03191	Homoserine kinase	SCHPO|PomBase=SPBC4C3.03|UniProtKB=O43056	Probable homoserine kinase	ISS			PTHR20861:SF1	HOMOSERINE KINASE
P00021	FGF signaling pathway	P00632	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MOUSE|MGI=MGI=2660854|UniProtKB=Q8C0T9	Adenylate cyclase type 10	ISS	11744988	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00059	p53 pathway	P04633	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	G01548	I-SMAD	DROME|FlyBase=FBgn0020493|UniProtKB=Q5U110	Mothers against decapentaplegic homolog	IGI	http://flybase.org/reports/FBgn0020493.html	Website	PTHR13703:SF44	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	DROME|FlyBase=FBgn0001105|UniProtKB=P26308	Guanine nucleotide-binding protein subunit beta-1	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	RAT|RGD=70487|UniProtKB=Q9WU82	Catenin beta-1	TAS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P00018	EGF receptor signaling pathway	P00551	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P05730	Endogenous cannabinoid signaling	P05751	Galpha	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00034	Integrin signalling pathway	P00924	Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	IPI	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	DROME|FlyBase=FBgn0004619|UniProtKB=Q03445	Glutamate receptor 1	ISS	12941441	PubMed	PTHR18966:SF270	GLUTAMATE RECEPTOR 1-RELATED
P00015	Circadian clock system	G01497	cry	CANLF|Ensembl=ENSCAFG00000001797|UniProtKB=E2RMX4	Uncharacterized protein	ISS	10428031	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	MOUSE|MGI=MGI=1339975|UniProtKB=O88643	Serine/threonine-protein kinase PAK 1	ISS	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	SULSO|EnsemblGenome=SSO0366|UniProtKB=P23794	Glutamine synthetase	ISS			PTHR43407:SF1	LENGSIN
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00010	B cell activation	P00386	Calcineurin	RAT|RGD=3382|UniProtKB=P63329	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	IDA	7532676	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	RCA	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00019	Endothelin signaling pathway	P00566	ERK	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00054	Toll receptor signaling pathway	P01368	MKK2	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00029	Huntington disease	P00778	NMDA receptor	PANTR|Ensembl=ENSPTRG00000004718|UniProtKB=H2Q5I0	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00048	PI3 kinase pathway	P01188	Gbetagamma	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00004	Alzheimer disease-presenilin pathway	P00111	C99	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	TAS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	PANTR|Ensembl=ENSPTRG00000030906|UniProtKB=Q5I1Z0	C-C motif chemokine 3	ISS			PTHR12015:SF91	C-C MOTIF CHEMOKINE 3-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	PANTR|Ensembl=ENSPTRG00000004718|UniProtKB=H2Q5I0	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00010	B cell activation	P00373	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01456	beta-arrestin	BOVIN|Ensembl=ENSBTAG00000020485|UniProtKB=P17870	Beta-arrestin-1	IDA	4757780	gi	PTHR11792:SF22	BETA-ARRESTIN-1
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00020	FAS signaling pathway	P00598	Pro-Caspase10	PANTR|Ensembl=ENSPTRG00000012800|UniProtKB=H2R694	Uncharacterized protein	ISS	11717445	PubMed	PTHR10454:SF26	CASPASE-10
P00057	Wnt signaling pathway	P01444	Wnt	BOVIN|Ensembl=ENSBTAG00000002664|UniProtKB=F1N7G3	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF84	PROTEIN WNT-9B
P00045	Notch signaling pathway	P01103	Next	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	1764995	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00034	Integrin signalling pathway	P00938	Cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	DANRE|ZFIN=ZDB-GENE-040426-2487|UniProtKB=Q803G3	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS			PTHR13808:SF5	CREB-BINDING PROTEIN
P00019	Endothelin signaling pathway	P00566	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	10218114	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00006	Apoptosis signaling pathway	P00322	Cytochrome C	MONDO|Ensembl=ENSMODG00000000653|UniProtKB=F6STW5	Uncharacterized protein	ISS	5933863	PubMed	PTHR11961:SF15	CYTOCHROME C
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ORNAN|Ensembl=ENSOANG00000000460|UniProtKB=F7F4W9	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	MACMU|Ensembl=ENSMMUG00000017022|UniProtKB=F7HQZ9	Uncharacterized protein	ISS	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	HUMAN|HGNC=418|UniProtKB=P09972	Fructose-bisphosphate aldolase C	ISS	7768978	PubMed	PTHR11627:SF3	FRUCTOSE-BISPHOSPHATE ALDOLASE C
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01160	IP3 receptor	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05918	p38 MAPK pathway	P05920	MAPKAP-K2	PANTR|Ensembl=ENSPTRG00000001915|UniProtKB=H2Q104	Mitogen-activated protein kinase-activated protein kinase 2	ISS	7923354	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	ORYSJ|EnsemblGenome=OS07G0624700|UniProtKB=Q7XI40	UMP-CMP kinase 3	ISS			PTHR23359:SF107	UMP-CMP KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P02785	Valine biosynthesis	P03216	Acetolactate synthase	PSEAE|EnsemblGenome=PA4180|UniProtKB=Q9HWK1	Probable acetolactate synthase large subunit	ISS			PTHR18968:SF129	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00990	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00310	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05913	Enkephalin release	P05974	G-Protein (i)	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01181	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00029	Huntington disease	P00778	NMDA receptor	MACMU|Ensembl=ENSMMUG00000001661|UniProtKB=F7GR69	Uncharacterized protein	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_79607|UniProtKB=C3ZHN4	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00053	T cell activation	P01322	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	IGI	12701063	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00055	Transcription regulation by bZIP transcription factor	P01389	TTF2	PANTR|Ensembl=ENSPTRG00000021496|UniProtKB=H2QY30	Uncharacterized protein	ISS			PTHR10641:SF939	TRANSCRIPTION TERMINATION FACTOR 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00047	PDGF signaling pathway	P01151	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00025	Hedgehog signaling pathway	P00690	Cubitus interruptus	DANRE|ZFIN=ZDB-GENE-990706-8|UniProtKB=B0S6T1	GLI-Kruppel family member GLI2a	ISS			PTHR19818:SF121	GLI-KRUPPEL FAMILY MEMBER GLI2A
P05730	Endogenous cannabinoid signaling	P05751	Galpha	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00310	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01435	SWI/SNF	MONDO|Ensembl=ENSMODG00000013187|UniProtKB=F7FAD4	Uncharacterized protein	ISS	11532957	PubMed	PTHR10799:SF819	GLOBAL TRANSCRIPTION ACTIVATOR SNF2L1-RELATED
P00029	Huntington disease	P00786	ARF	YEAST|SGD=S000000368|UniProtKB=P38116	ADP-ribosylation factor-like protein 1	IPI	12932731	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	HUMAN|HGNC=9561|UniProtKB=P55036	26S proteasome non-ATPase regulatory subunit 4	ISS	13645506	gi	PTHR10223:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4
P00005	Angiogenesis	P00219	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS			PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05915	Opioid proenkephalin pathway	P05992	met-Enkephalin	HUMAN|HGNC=8831|UniProtKB=P01210	Proenkephalin-A	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00021	FGF signaling pathway	P00638	PLCgamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04395	Vasopressin synthesis	P04589	Signal Peptidase	DROME|FlyBase=FBgn0262801|UniProtKB=O97066	Signal peptidase complex catalytic subunit SEC11	IC	2092035	PubMed	PTHR10806:SF6	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11
P00021	FGF signaling pathway	P00631	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	11384839	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00021	FGF signaling pathway	P00633	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IGI	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P04397	p53 pathway by glucose deprivation	P04641	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00221	JNK1	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00234	Grb2	DANRE|ZFIN=ZDB-GENE-040426-1975|UniProtKB=Q6PC73	Growth factor receptor-bound protein 2	ISS	4504111	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00005	Angiogenesis	P00208	MEKK1	MACMU|Ensembl=ENSMMUG00000012387|UniProtKB=F7EB20	Uncharacterized protein	ISS	8940199	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	TAS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04393	Ras Pathway	P04578	Rho	DANRE|ZFIN=ZDB-GENE-040718-144|UniProtKB=Q6DHE8	Rho-related GTP-binding protein RhoA-D	ISS	10556059	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	YARLI|EnsemblGenome=YALI0_D08272g|UniProtKB=Q9UVF3	Actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P06959	CCKR signaling map	P07202	SRC	HUMAN|HGNC=11283|UniProtKB=P12931	Proto-oncogene tyrosine-protein kinase Src	RCA	12551923	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00006	Apoptosis signaling pathway	P00299	Caspase 8	RAT|RGD=620945|UniProtKB=Q9JHX4	Caspase-8	ISS	11788820	PubMed	PTHR10454:SF162	CASPASE-8
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00021	FGF signaling pathway	P00645	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P02785	Valine biosynthesis	P03218	Dihydroxy isovalerate dehydratase	ARATH|TAIR=AT3G23940|UniProtKB=Q9LIR4	Dihydroxy-acid dehydratase, chloroplastic	ISS			PTHR21000:SF17	DIHYDROXY-ACID DEHYDRATASE, CHLOROPLASTIC
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00648	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	CHICK|Ensembl=ENSGALG00000008512|UniProtKB=F1P0S6	Uncharacterized protein	ISS	20112749	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	1718748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01465	Ggamma	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00041	Metabotropic glutamate receptor group I pathway	P01062	mGluR1	MACMU|Ensembl=ENSMMUG00000016428|UniProtKB=F7GU00	Metabotropic glutamate receptor 1 isoform alpha	ISS	12488551	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00034	Integrin signalling pathway	P00951	Jnk	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	15572354	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00322	Cytochrome C	MACMU|Ensembl=ENSMMUG00000016443|UniProtKB=F7GTP8	Uncharacterized protein	ISS	4954366	PubMed	PTHR11961:SF15	CYTOCHROME C
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	TAKRU|Ensembl=ENSTRUG00000008723|UniProtKB=H2TB66	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF331	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00036	Interleukin signaling pathway	P00981	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00017	DNA replication	P00530	Top	RAT|RGD=62048|UniProtKB=P41516	DNA topoisomerase 2-alpha	RCA			PTHR10169:SF46	DNA TOPOISOMERASE 2-ALPHA
P00019	Endothelin signaling pathway	P00590	IP3 R	CAEEL|WormBase=WBGene00002173|UniProtKB=Q9Y0A1	Inositol 1,4,5-trisphosphate receptor itr-1	ISS	9065779	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00009	Axon guidance mediated by netrin	P00366	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MACMU|Ensembl=ENSMMUG00000006702|UniProtKB=F7HJS7	Serine/threonine-protein kinase receptor	ISS	10683140	PubMed	PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P00005	Angiogenesis	P00193	SOS-1	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00005	Angiogenesis	P00186	FGFR-1	XENTR|Xenbase=XB-GENE-1018554|UniProtKB=Q28J96	Fibroblast growth factor receptor	ISS	2172985	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONBE|Gene=37852|UniProtKB=A9V489	Predicted protein	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00811	Arp2/3 complex	ANOGA|EnsemblGenome=AGAP008908|UniProtKB=Q7PWN2	AGAP008908-PA	TAS	12963527	gi	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P00047	PDGF signaling pathway	P01152	RasGAP	BOVIN|Ensembl=ENSBTAG00000015413|UniProtKB=F1N795	Uncharacterized protein	ISS	20475167	gi	PTHR10194:SF21	RAS GTPASE-ACTIVATING PROTEIN 2
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00539	14-3-3	YEAST|SGD=S000000979|UniProtKB=P29311	Protein BMH1	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00005	Angiogenesis	P00203	Erk	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00632	Akt	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	IGI	12719720	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Gene=DRD2|UniProtKB=P20288	D(2) dopamine receptor	IDA	2039532	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	9332390	PubMed	PTHR10202:SF13	PRESENILIN-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	LEIMA|EnsemblGenome=LmjF.04.1230|UniProtKB=Q9U1E8	Actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05731	GABA-B receptor II signaling	P05754	Ggamma	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	MOUSE|MGI=MGI=1914007|UniProtKB=Q6P6J0	tRNA-specific adenosine deaminase 2	ISS			PTHR11079:SF92	TRNA-SPECIFIC ADENOSINE DEAMINASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008422|UniProtKB=F6VUT7	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	RHOBA|EnsemblGenome=RB10172|UniProtKB=Q7UFE0	Aldehyde dehydrogenase	IC			PTHR11699:SF211	ALDEHYDE DEHYDROGENASE 5, MITOCHONDRIAL
P00012	Cadherin signaling pathway	P00470	F-actin	DANRE|ZFIN=ZDB-GENE-000322-1|UniProtKB=Q9I8V1	Actin, alpha 1, skeletal muscle	IC	11889139	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00010	B cell activation	P00385	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00017	DNA replication	P00527	Histones	CRYNJ|EnsemblGenome=CNJ02540|UniProtKB=P0CO04	Histone H3	ISS	20448842	PubMed	PTHR11426:SF47	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02785	Valine biosynthesis	P03216	Acetolactate synthase	METAC|EnsemblGenome=MA_3792|UniProtKB=Q8TJJ2	Acetolactate synthase	ISS			PTHR18968:SF13	ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	XENTR|Xenbase=XB-GENE-484003|UniProtKB=Q6P365	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P02761	Pantothenate biosynthesis	P03066	Aspartate decarboxylase	GLOVI|EnsemblGenome=BAC90786|UniProtKB=Q7NCY1	Aspartate 1-decarboxylase 1	ISS			PTHR21012:SF0	ASPARTATE 1-DECARBOXYLASE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PHYPA|Gene=PHYPADRAFT_226658|UniProtKB=A9TYG3	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01202	p85	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	10747026	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00049	Parkinson disease	P01211	ERK	CANLF|Ensembl=ENSCAFG00000018202|UniProtKB=E2RPJ2	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	RCA	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=621787|UniProtKB=O88278	Cadherin EGF LAG seven-pass G-type receptor 3	IDA	8120095	PubMed	PTHR24026:SF38	CADHERIN EGF LAG SEVEN-PASS G-TYPE RECEPTOR 3
P00036	Interleukin signaling pathway	P00990	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00041	Metabotropic glutamate receptor group I pathway	P01062	mGluR1	PANTR|Ensembl=ENSPTRG00000018684|UniProtKB=C7G3M7	Glutamate receptor, metabotropic 1	ISS	8314195	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00011	Blood coagulation	P00414	Thrombin	BOVIN|Ensembl=ENSBTAG00000007148|UniProtKB=P00735	Prothrombin	ISS	+176930	OMIM	PTHR24254:SF10	PROTHROMBIN
P00005	Angiogenesis	P00184	Src	MONDO|Ensembl=ENSMODG00000000247|UniProtKB=F6WR53	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00049	Parkinson disease	P01215	Syntaxin	RAT|RGD=620977|UniProtKB=G3V7P1	Syntaxin-12	ISS	14570579	PubMed	PTHR19957:SF88	SYNTAXIN-12
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	IDA	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	IDA	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MACMU|Ensembl=ENSMMUG00000014597|UniProtKB=F6VAQ6	Glycogen synthase kinase-3 alpha	ISS	12086949	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_56698|UniProtKB=C3XYC3	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	RCA	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04398	p53 pathway feedback loops 2	P04651	Ras	MOUSE|MGI=MGI=96680|UniProtKB=P32883	GTPase KRas	IDA	6287573	PubMed	PTHR24070:SF186	GTPASE KRAS
P05916	Opioid prodynorphin pathway	P06001	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00018	EGF receptor signaling pathway	P00547	PP2A	HUMAN|HGNC=9300|UniProtKB=P62714	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	NAS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	PANTR|Ensembl=ENSPTRG00000023608|UniProtKB=H2QZZ2	Uncharacterized protein	ISS	11554554	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	RCA	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05731	GABA-B receptor II signaling	P05754	Ggamma	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00019	Endothelin signaling pathway	P00570	PKA	DICDI|dictyBase=DDB_G0279413|UniProtKB=P05987	cAMP-dependent protein kinase regulatory subunit	IGI	2372396	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00642	MEK1-2	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	PANTR|Ensembl=ENSPTRG00000039101|UniProtKB=H2RFN4	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR15936:SF2	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-13
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	HUMAN|HGNC=7572|UniProtKB=Q9UKX2	Myosin-2	ISS	10938134	PubMed	PTHR13140:SF385	MYOSIN-2
P00018	EGF receptor signaling pathway	P00542	EGFR	BOVIN|Ensembl=ENSBTAG00000021798|UniProtKB=F1MCQ7	Receptor protein-tyrosine kinase	ISS	4758298	gi	PTHR24416:SF137	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	BOVIN|Ensembl=ENSBTAG00000010191|UniProtKB=Q08E52	Serine/threonine-protein kinase PAK 1	ISS	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00048	PI3 kinase pathway	P01199	Galpha	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	XENTR|Xenbase=XB-GENE-487200|UniProtKB=Q28GC2	Catenin (Cadherin associated protein), beta 1, 88kDa	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00052	TGF-beta signaling pathway	P01275	P38	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	8920915	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00624	14-3-3	ORNAN|Ensembl=ENSOANG00000004145|UniProtKB=F7A0H3	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P04393	Ras Pathway	P04547	Ras	TAKRU|Ensembl=ENSTRUG00000005329|UniProtKB=H2SK54	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MOUSE|MGI=MGI=95819|UniProtKB=P35438	Glutamate receptor ionotropic, NMDA 1	IC	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00049	Parkinson disease	P01211	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00634	MEKK1-5	RAT|RGD=620967|UniProtKB=F1M9D0	Protein Map3k2	ISS	21735556	gi	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01081	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000019350|UniProtKB=H2R2A6	Calcium channel, voltage-dependent, alpha 2/delta subunit 1	ISS	92228762	PubMed	PTHR10166:SF6	VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-1
P00052	TGF-beta signaling pathway	P01288	FKBP12	CHICK|Ensembl=ENSGALG00000016500|UniProtKB=F6SVS4	Peptidyl-prolyl cis-trans isomerase	ISS			PTHR10516:SF309	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1B
P00057	Wnt signaling pathway	P01444	Wnt	MACMU|Ensembl=ENSMMUG00000015705|UniProtKB=F6SM00	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00025	Hedgehog signaling pathway	P00682	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01428	Frizzled	RAT|RGD=628816|UniProtKB=G3V6L1	Frizzled homolog 6 (Drosophila)	ISS	8717036	PubMed	PTHR11309:SF75	FRIZZLED-6
P00056	VEGF signaling pathway	P01417	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00007	Axon guidance mediated by semaphorins	P00340	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12176041	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	BOVIN|Ensembl=ENSBTAG00000001192|UniProtKB=A7MAZ2	STX12 protein	ISS	10321247	PubMed	PTHR19957:SF88	SYNTAXIN-12
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00034	Integrin signalling pathway	P00916	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P02742	Tetrahydrofolate biosynthesis	P02951	GTP cyclohydrolase	ARATH|TAIR=AT3G07270|UniProtKB=Q9SFV7	GTP cyclohydrolase 1	ISS			PTHR11109:SF0	GTP CYCLOHYDROLASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00005	Angiogenesis	P00206	Wnt	DANRE|ZFIN=ZDB-GENE-051129-1|UniProtKB=Q4JLT0	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00570	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	IDA	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P05916	Opioid prodynorphin pathway	P06002	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00013	Cell cycle	P00481	APC	SCHPO|PomBase=SPBC1A4.01|UniProtKB=O42971	Anaphase-promoting complex subunit 10	ISS	19112595	gi	PTHR12936:SF0	ANAPHASE-PROMOTING COMPLEX SUBUNIT 10
P00041	Metabotropic glutamate receptor group I pathway	P01062	mGluR1	HUMAN|HGNC=4593|UniProtKB=Q13255	Metabotropic glutamate receptor 1	ISS	12488551	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01212	p38 MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00256	PLC-gamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00006	Apoptosis signaling pathway	P00313	IKK	MOUSE|MGI=MGI=1338071|UniProtKB=O88351	Inhibitor of nuclear factor kappa-B kinase subunit beta	IDA	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	CANLF|Ensembl=ENSCAFG00000030049|UniProtKB=J9NWQ5	Uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF311	CALMODULIN
P02779	Thiamin biosynthesis	P03170	Hydroxymethylpyrimidine phosphate kinase	ARATH|TAIR=AT1G22940|UniProtKB=Q5M731	Thiamine biosynthetic bifunctional enzyme TH1, chloroplastic	ISS			PTHR20858:SF17	HYDROXYMETHYLPYRIMIDINE/PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED
P00047	PDGF signaling pathway	P01153	GSK3	BOVIN|Ensembl=ENSBTAG00000020756|UniProtKB=A6QLB8	GSK3A protein	ISS	11995474	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	MOUSE|MGI=MGI=99474|UniProtKB=Q91YI4	Beta-arrestin-2	IDA	9388255	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00005	Angiogenesis	P00223	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01275	P38	DANRE|ZFIN=ZDB-GENE-990415-257|UniProtKB=O42376	Mitogen-activated protein kinase 12	TAS	10514528	PubMed	PTHR24055:SF339	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DICPU|Gene=DICPUDRAFT_98135|UniProtKB=F0ZMZ8	Putative uncharacterized protein racE	ISS			PTHR24072:SF143	RHO-RELATED PROTEIN RACE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	BOVIN|Ensembl=ENSBTAG00000009175|UniProtKB=E1BLQ5	Uncharacterized protein	ISS	6755374	gi	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00020	FAS signaling pathway	P00615	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00029	Huntington disease	P00805	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01322	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00019	Endothelin signaling pathway	P00591	PLCbeta	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	MOUSE|MGI=MGI=109482|UniProtKB=P97445	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	11976940	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	TAS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00049	Parkinson disease	P01215	Syntaxin	ORNAN|Ensembl=ENSOANG00000010187|UniProtKB=F7E0A0	Uncharacterized protein	ISS	14570579	PubMed	PTHR19957:SF90	SYNTAXIN-7
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01173	STAT	BOVIN|Gene=STAT5A|UniProtKB=Q95115	Signal transducer and activator of transcription 5A	ISS	95236292	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	RAT|Ensembl=ENSRNOG00000058111|UniProtKB=A0A0G2K470	Protein Itga2	ISS	3487386	PubMed	PTHR23220:SF23	INTEGRIN ALPHA-2
P00007	Axon guidance mediated by semaphorins	P00340	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	TAS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04393	Ras Pathway	P04570	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	DROME|FlyBase=FBgn0015519|UniProtKB=Q9W3G6	Nicotinic acetylcholine receptor alpha3, isoform B	IC	85270494	PubMed	PTHR18945:SF758	NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA3, ISOFORM B
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	BOVIN|Gene=INS|UniProtKB=P01317	Insulin	ISS			PTHR11454:SF9	INSULIN-RELATED
P02723	Adenine and hypoxanthine salvage pathway	P02808	Deoxyadenosine phosphorylase	PANTR|Ensembl=ENSPTRG00000006095|UniProtKB=H2Q7W4	Purine nucleoside phosphorylase	ISS			PTHR11904:SF12	PURINE NUCLEOSIDE PHOSPHORYLASE
P00018	EGF receptor signaling pathway	P00565	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MOUSE|MGI=MGI=1933206|UniProtKB=A2AIR5	Protein Grin3a	ISS	11319238	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04393	Ras Pathway	P04542	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DROME|FlyBase=FBgn0261854|UniProtKB=A1Z9X0	Atypical protein kinase C	ISS	2837282	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00859	NFkappaB	BOVIN|Ensembl=ENSBTAG00000038428|UniProtKB=G3N1S2	Uncharacterized protein	RCA			PTHR24169:SF18	TRANSCRIPTION FACTOR RELB
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-040718-93|UniProtKB=Q6DGZ5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00001	Adrenaline and noradrenaline biosynthesis	P00062	TH	PANTR|Ensembl=ENSPTRG00000003173|UniProtKB=H2Q2W7	Uncharacterized protein	ISS	12814656	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00049	Parkinson disease	P01208	Hsp70	MACMU|Ensembl=ENSMMUG00000006799|UniProtKB=F7H1B9	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF239	HEAT SHOCK COGNATE 71 KDA PROTEIN
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01089	VAChT	HUMAN|HGNC=10936|UniProtKB=Q16572	Vesicular acetylcholine transporter	IC			PTHR23506:SF13	VESICULAR ACETYLCHOLINE TRANSPORTER
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	CANLF|Ensembl=ENSCAFG00000010107|UniProtKB=E2RA74	Serine/threonine-protein kinase receptor	ISS	10683140	PubMed	PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01292	RSmads	DANRE|ZFIN=ZDB-GENE-031014-1|UniProtKB=F1QXZ9	Mothers against decapentaplegic homolog	ISS			PTHR13703:SF41	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 9
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00018	EGF receptor signaling pathway	P00551	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	SCHPO|PomBase=SPBC14F5.05c|UniProtKB=O60198	S-adenosylmethionine synthase	ISS			PTHR11964:SF1	S-ADENOSYLMETHIONINE SYNTHASE
P00034	Integrin signalling pathway	P00942	Fyn	HUMAN|HGNC=4037|UniProtKB=P06241	Tyrosine-protein kinase Fyn	IPI	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	CANLF|Ensembl=ENSCAFG00000002046|UniProtKB=E2RBE7	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	CANLF|Ensembl=ENSCAFG00000002046|UniProtKB=E2RBE7	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02748	Isoleucine biosynthesis	P02994	Branched chain amino acid aminotransferase	PANTR|Ensembl=ENSPTRG00000011258|UniProtKB=H2QGS7	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF39	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, MITOCHONDRIAL
P00005	Angiogenesis	P00231	HSP27	MOUSE|MGI=MGI=1916503|UniProtKB=Q99PR8	Heat shock protein beta-2	ISS			PTHR11527:SF163	HEAT SHOCK PROTEIN BETA-2
P00049	Parkinson disease	P01227	20S proteasome	MACMU|Ensembl=ENSMMUG00000016544|UniProtKB=F6W663	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF11	PROTEASOME SUBUNIT ALPHA TYPE-6
P00021	FGF signaling pathway	P00647	SHP2	MOUSE|MGI=MGI=99511|UniProtKB=P35235	Tyrosine-protein phosphatase non-receptor type 11	IPI	8096088	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00060	Ubiquitin proteasome pathway	P01492	E1	CHICK|Ensembl=ENSGALG00000013410|UniProtKB=E1BT61	Uncharacterized protein	ISS			PTHR10953:SF6	NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT
P00047	PDGF signaling pathway	P01143	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00009	Axon guidance mediated by netrin	P00366	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00036	Interleukin signaling pathway	P00976	GSK3	STRPU|EnsemblGenome=SPU_009263|UniProtKB=W4Y0P1	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00049	Parkinson disease	P01238	14-3-3	CANLF|Ensembl=ENSCAFG00000000580|UniProtKB=F1PBL1	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00006	Apoptosis signaling pathway	P00305	Caspase 3	DANRE|ZFIN=ZDB-GENE-011210-1|UniProtKB=B8JK21	Uncharacterized protein	ISS	11675509	PubMed	PTHR10454:SF198	CASPASE-3
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	YEAST|SGD=S000004048|UniProtKB=P37291	Serine hydroxymethyltransferase, cytosolic	ISS			PTHR11680:SF25	SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04393	Ras Pathway	P04578	Rho	PANTR|Ensembl=ENSPTRG00000014922|UniProtKB=H2QML4	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00057	Wnt signaling pathway	P01428	Frizzled	PANTR|Ensembl=ENSPTRG00000029908|UniProtKB=H2R050	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF90	FRIZZLED-8
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P04609	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00013	Cell cycle	P00480	Proteasome	HUMAN|HGNC=9561|UniProtKB=P55036	26S proteasome non-ATPase regulatory subunit 4	IEA	13645506	gi	PTHR10223:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00047	PDGF signaling pathway	P01152	RasGAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	2574500	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00019	Endothelin signaling pathway	P00583	cPLA2	PANTR|Ensembl=ENSPTRG00000001787|UniProtKB=H2Q0T0	Phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00005	Angiogenesis	P00223	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=3784|UniProtKB=P61265	Syntaxin-1B	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	BOVIN|Ensembl=ENSBTAG00000010863|UniProtKB=F1N4I7	Uncharacterized protein	ISS			PTHR16290:SF4	MRNA-DECAPPING ENZYME 1A
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	MOUSE|MGI=MGI=1349763|UniProtKB=O08553	Dihydropyrimidinase-related protein 2	TAS	7637782	PubMed	PTHR11647:SF56	DIHYDROPYRIMIDINASE-RELATED PROTEIN 2
P00060	Ubiquitin proteasome pathway	P01490	E3	MONDO|Ensembl=ENSMODG00000001079|UniProtKB=F7GHZ3	Uncharacterized protein	ISS	11252892	PubMed	PTHR11254:SF293	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P00047	PDGF signaling pathway	P01161	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P02734	Chorismate biosynthesis	P02868	Chorismate synthase	ARATH|TAIR=AT1G48850|UniProtKB=P57720	Chorismate synthase, chloroplastic	ISS			PTHR21085:SF0	CHORISMATE SYNTHASE
P00047	PDGF signaling pathway	P01159	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MONDO|Ensembl=ENSMODG00000001775|UniProtKB=F6WJB1	Uncharacterized protein	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	DROME|FlyBase=FBgn0025641|UniProtKB=M9MSM5	Dishevelled associated activator of morphogenesis, isoform D	IC			PTHR23213:SF328	DISHEVELLED ASSOCIATED ACTIVATOR OF MORPHOGENESIS, ISOFORM D
P00034	Integrin signalling pathway	P00907	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02721	ATP synthesis	P02798	Cyt C	MACMU|Ensembl=ENSMMUG00000032138|UniProtKB=F7GRC6	Uncharacterized protein	ISS	4954366	PubMed	PTHR11961:SF15	CYTOCHROME C
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	HUMAN|HGNC=1392|UniProtKB=Q15878	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	8386525	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS			PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CAEEL|WormBase=WBGene00002974|UniProtKB=Q27218	Acetylcholine receptor subunit beta-type lev-1	IC	22213672	PubMed	PTHR18945:SF747	ACETYLCHOLINE RECEPTOR SUBUNIT BETA-TYPE LEV-1
P00057	Wnt signaling pathway	P01444	Wnt	RAT|RGD=1304559|UniProtKB=D4A3W9	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00866	Cytokine receptor	MOUSE|MGI=MGI=109380|UniProtKB=Q61190	Interleukin-10 receptor subunit beta	IDA	9463407	PubMed	PTHR20859:SF50	INTERLEUKIN-10 RECEPTOR SUBUNIT BETA
P00019	Endothelin signaling pathway	P00575	furin	RAT|RGD=3272|UniProtKB=P28840	Neuroendocrine convertase 1	ISS			PTHR42884:SF14	NEUROENDOCRINE CONVERTASE 1
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	ISS	12168099	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04375	5HT3 type receptor mediated signaling pathway	P04425	K+ channel	BOVIN|Ensembl=ENSBTAG00000047488|UniProtKB=G3N1D1	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00034	Integrin signalling pathway	P00911	B-Raf	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS	12068308	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00044	Nicotinic acetylcholine receptor signaling pathway	P01092	delta	BOVIN|Ensembl=ENSBTAG00000011390|UniProtKB=P04759	Acetylcholine receptor subunit delta	ISS	85203892	PubMed	PTHR18945:SF61	ACETYLCHOLINE RECEPTOR SUBUNIT DELTA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00018	EGF receptor signaling pathway	P00551	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	TAS	9298898	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01148	Grb2	PANTR|Ensembl=ENSPTRG00000009642|UniProtKB=G2HGD2	Growth factor receptor-bound protein 2	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00019	Endothelin signaling pathway	P00589	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	3045562	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	IC	10514528	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P06664	Gonadotropin-releasing hormone receptor pathway	P06728	Caln	MOUSE|MGI=MGI=107164|UniProtKB=P63328	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	RCA	12091710	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00220	c-Jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	CHICK|Ensembl=ENSGALG00000011473|UniProtKB=F1P1H2	Ribosomal protein S6 kinase	ISS	15526037	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00049	Parkinson disease	P01238	14-3-3	DAPPU|EnsemblGenome=DAPPUDRAFT_307391|UniProtKB=E9H1W5	14-3-3 zeta	ISS	10407019	PubMed	PTHR18860:SF13	14-3-3 PROTEIN ZETA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05915	Opioid proenkephalin pathway	P05993	AC	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00029	Huntington disease	P00812	Caspase 3	MACMU|Ensembl=ENSMMUG00000012053|UniProtKB=F7HFY2	Uncharacterized protein	ISS	11675509	PubMed	PTHR10454:SF198	CASPASE-3
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00046	Oxidative stress response	P01128	MEF-2	PANTR|Ensembl=ENSPTRG00000024214|UniProtKB=H2R001	Uncharacterized protein	ISS	11274345	PubMed	PTHR11945:SF25	MYOCYTE-SPECIFIC ENHANCER FACTOR 2C
P00029	Huntington disease	P00779	TBP	TETTS|EnsemblGenome=TTHERM_00575350|UniProtKB=Q22V65	TATA box-binding protein (TBP): present in archaea and protein	IPI	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00045	Notch signaling pathway	P01101	Su(H)	HUMAN|HGNC=13761|UniProtKB=Q9UBG7	Recombining binding protein suppressor of hairless-like protein	IC			PTHR10665:SF2	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS-LIKE PROTEIN
P00047	PDGF signaling pathway	P01160	IP3 receptor	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05913	Enkephalin release	P05974	G-Protein (i)	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	IDA	12736250	PubMed	PTHR10202:SF18	PRESENILIN-1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00008	Axon guidance mediated by Slit/Robo	P00344	Netrin	PANTR|Ensembl=ENSPTRG00000007651|UniProtKB=H2QAD5	Uncharacterized protein	ISS			PTHR10574:SF292	NETRIN-3
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	MOUSE|MGI=MGI=106217|UniProtKB=Q61290	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	14507926	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	BOVIN|Ensembl=ENSBTAG00000011723|UniProtKB=E1BKL6	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00057	Wnt signaling pathway	P01465	Ggamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00034	Integrin signalling pathway	P00939	Fibronectin	RAT|RGD=2624|UniProtKB=P04937	Fibronectin	IDA	12970173	PubMed	PTHR19143:SF267	FIBRONECTIN
P00036	Interleukin signaling pathway	P00990	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ORYSJ|EnsemblGenome=OS01G0267200|UniProtKB=Q9SDD1	26S proteasome regulatory particle non-ATPase subunit11	ISS			PTHR10410:SF5	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 14
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00047	PDGF signaling pathway	P01143	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04395	Vasopressin synthesis	P04589	Signal Peptidase	CHICK|Ensembl=ENSGALG00000002839|UniProtKB=F1NAZ9	Signal peptidase complex catalytic subunit SEC11	ISS	2092035	PubMed	PTHR10806:SF12	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11C
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	BOVIN|Gene=MYH2|UniProtKB=Q9BE41	Myosin-2	IEP	89264452	PubMed	PTHR13140:SF385	MYOSIN-2
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00859	NFkappaB	MOUSE|MGI=MGI=1099800|UniProtKB=Q9WTK5	Nuclear factor NF-kappa-B p100 subunit	IDA	9133421	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00059	p53 pathway	G04694	p110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	IC	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04398	p53 pathway feedback loops 2	P04657	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00774	Dynein complex	CAEEL|WormBase=WBGene00000485|UniProtKB=Q19542	Cytoplasmic dynein 2 heavy chain 1	IPI	9454836	PubMed	PTHR10676:SF352	CYTOPLASMIC DYNEIN 2 HEAVY CHAIN 1
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00018	EGF receptor signaling pathway	P00542	EGFR	MACMU|Ensembl=ENSMMUG00000020758|UniProtKB=F7HEH3	Uncharacterized protein	ISS	17432904	gi	PTHR24416:SF88	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00009	Axon guidance mediated by netrin	P00363	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MACMU|Ensembl=ENSMMUG00000014245|UniProtKB=F7C4E6	Uncharacterized protein	ISS	8817552	PubMed	PTHR43893:SF5	HISTAMINE H2 RECEPTOR
P00036	Interleukin signaling pathway	P00965	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04666	cyclin A	RAT|RGD=1310639|UniProtKB=Q6AY13	Cyclin-A1	RCA			PTHR10177:SF254	CYCLIN-A1
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	MONDO|Ensembl=ENSMODG00000018507|UniProtKB=F7AGY1	Uncharacterized protein	ISS	10778855	PubMed	PTHR45047:SF2	COLLAGEN ALPHA-1 XII  CHAIN
P00005	Angiogenesis	P00219	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00034	Integrin signalling pathway	P00948	Rho	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	IGI	12039949	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00211	GSK3beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04393	Ras Pathway	P04541	p90RSK	CHICK|Ensembl=ENSGALG00000000366|UniProtKB=P18652	Ribosomal protein S6 kinase 2 alpha	IDA	2779569	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	ANOGA|EnsemblGenome=AGAP001394|UniProtKB=F5HMS4	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04398	p53 pathway feedback loops 2	P04661	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	MYCTU|EnsemblGenome=Rv1093|UniProtKB=P9WGI9	Serine hydroxymethyltransferase 1	ISS			PTHR11680:SF21	SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	RAT|RGD=621516|UniProtKB=G3V6P8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00018	EGF receptor signaling pathway	P00562	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	ISS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00035	Interferon-gamma signaling pathway	P00959	IFNGR1	PANTR|Ensembl=ENSPTRG00000018642|UniProtKB=H2R6X1	Interferon gamma receptor 1	ISS	14525967	PubMed	PTHR20859:SF5	INTERFERON GAMMA RECEPTOR 1
P00030	Hypoxia response via HIF activation	P00824	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	TAS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	CHICK|Gene=KCNJ3|UniProtKB=Q90854	G protein-activated inward rectifier potassium channel 1	IDA			PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00010	B cell activation	P00371	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00547	PP2A	MACMU|Ensembl=ENSMMUG00000008205|UniProtKB=F7GWP9	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	ISS	8703017	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01020	NSF	RAT|RGD=621594|UniProtKB=Q9QUL6	Vesicle-fusing ATPase	ISS	11348590	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P02738	De novo purine biosynthesis	P02894	IMP cyclohydrolase	YEAST|SGD=S000004018|UniProtKB=P54113	Bifunctional purine biosynthesis protein ADE16	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	XENTR|Xenbase=XB-GENE-491618|UniProtKB=Q6P378	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00049	Parkinson disease	P01208	Hsp70	CHICK|Ensembl=ENSGALG00000001000|UniProtKB=Q90593	78 kDa glucose-regulated protein	IDA	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00056	VEGF signaling pathway	P01417	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00005	Angiogenesis	P00203	Erk	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01185	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04393	Ras Pathway	P04567	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHICK|Ensembl=ENSGALG00000009621|UniProtKB=P60706	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	DROME|FlyBase=FBgn0026373|UniProtKB=O97183	GH07456p	ISS	2187864	PubMed	PTHR11800:SF2	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3
P00036	Interleukin signaling pathway	P00981	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00021	FGF signaling pathway	P00634	MEKK1-5	HUMAN|HGNC=6855|UniProtKB=Q99759	Mitogen-activated protein kinase kinase kinase 3	IGI	8649450	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05731	GABA-B receptor II signaling	P05758	K channel	HUMAN|HGNC=6264|UniProtKB=P48549	G protein-activated inward rectifier potassium channel 1	RCA	12374786	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000025373|UniProtKB=F6ZZG9	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00060	Ubiquitin proteasome pathway	P01491	E2	DAPPU|EnsemblGenome=DAPPUDRAFT_120690|UniProtKB=E9I205	Putative uncharacterized protein	ISS			PTHR24068:SF74	FI16911P1-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	CANLF|Ensembl=ENSCAFG00000018170|UniProtKB=E2RPM8	Tyrosine-protein kinase receptor	ISS	2983222	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P00024	Glycolysis	P00676	Glyceraldehyde 3-phosphate dehydrogenase	DROME|FlyBase=FBgn0001092|UniProtKB=P07487	Glyceraldehyde-3-phosphate dehydrogenase 2	RCA			PTHR10836:SF52	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	PANTR|Ensembl=ENSPTRG00000008769|UniProtKB=H2R9J3	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF681	MYOSIN-4
P00053	T cell activation	P01320	PLC-gamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	LEIMA|EnsemblGenome=LmjF.36.6470|UniProtKB=Q4Q0B0	Mitogen-activated protein kinase	ISS			PTHR24055:SF178	SUBFAMILY NOT NAMED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=107469|UniProtKB=Q8K3R3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	10934033	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00005	Angiogenesis	P00223	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00055	Transcription regulation by bZIP transcription factor	P01392	TFIIH complex	PANTR|Ensembl=ENSPTRG00000005604|UniProtKB=H2R726	Uncharacterized protein	ISS			PTHR12831:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	TAS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P02723	Adenine and hypoxanthine salvage pathway	P02807	Deoxyadenosine deaminase	EMENI|EnsemblGenome=CADANIAG00006939|UniProtKB=Q8X1T6	Adenine deaminase	ISS			PTHR43114:SF2	ADENINE DEAMINASE
P00005	Angiogenesis	P00251	cPLA2	PANTR|Ensembl=ENSPTRG00000001787|UniProtKB=H2Q0T0	Phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05916	Opioid prodynorphin pathway	P06002	G-protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	TAS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00892	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12186904	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00049	Parkinson disease	P01236	Casein kinase II	ARATH|TAIR=AT2G23070|UniProtKB=O64816	Casein kinase II subunit alpha, chloroplastic	IDA	10806215	PubMed	PTHR24054:SF33	CASEIN KINASE II SUBUNIT ALPHA, CHLOROPLASTIC
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00056	VEGF signaling pathway	P01425	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00048	PI3 kinase pathway	P01185	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	RAT|RGD=620142|UniProtKB=Q9JLB5	Neuronal acetylcholine receptor subunit alpha-10	IC			PTHR18945:SF768	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-10
P04393	Ras Pathway	P04541	p90RSK	BOVIN|Ensembl=ENSBTAG00000017639|UniProtKB=F1MZW8	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00391	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05755	Gbeta	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	CANLF|Ensembl=ENSCAFG00000002617|UniProtKB=E2QUL1	Uncharacterized protein	ISS	11554554	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00021	FGF signaling pathway	P00626	Spry	PANTR|Ensembl=ENSPTRG00000016424|UniProtKB=H2QQ50	Sprouty homolog 1, antagonist of FGF signaling	ISS	98117253	PubMed	PTHR12365:SF10	PROTEIN SPROUTY HOMOLOG 1
P00052	TGF-beta signaling pathway	P01275	P38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	CANLF|Ensembl=ENSCAFG00000017679|UniProtKB=E2RMD8	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	BOVIN|Ensembl=ENSBTAG00000018989|UniProtKB=A5D7D8	GRM3 protein	ISS	12488551	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00054	Toll receptor signaling pathway	P01358	ERK1	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00508	Cofilin	CANLF|Ensembl=ENSCAFG00000032562|UniProtKB=J9P2G7	Uncharacterized protein	ISS			PTHR11913:SF15	COFILIN-2
P00056	VEGF signaling pathway	P01413	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	10799299	PubMed	PTHR10048:SF14	PI-3 KINASE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	PANTR|Ensembl=ENSPTRG00000012855|UniProtKB=H2QJA9	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF126	FRIZZLED-5
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	XENTR|Xenbase=XB-GENE-482228|UniProtKB=F6RYL1	Uncharacterized protein	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00021	FGF signaling pathway	P00629	PP2A	MACMU|Ensembl=ENSMMUG00000013047|UniProtKB=F7H808	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	10514528	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	PANTR|Ensembl=ENSPTRG00000019277|UniProtKB=H2QUQ1	Uncharacterized protein	ISS	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00030	Hypoxia response via HIF activation	P00823	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05989	leu-Enkephalin	BOVIN|Ensembl=ENSBTAG00000004924|UniProtKB=P01211	Proenkephalin-A	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	ARATH|TAIR=AT4G34460|UniProtKB=P49177	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF48	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MOUSE|MGI=MGI=1346876|UniProtKB=O35099	Mitogen-activated protein kinase kinase kinase 5	ISS	12697749	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	NEUCR|EnsemblGenome=EFNCRG00000000159|UniProtKB=F5HH30	Guanine nucleotide-binding protein beta subunit	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06838	CTNNB1	MOUSE|MGI=MGI=88276|UniProtKB=Q02248	Catenin beta-1	RCA	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00204	PLD	MOUSE|MGI=MGI=892877|UniProtKB=P97813	Phospholipase D2	ISS	15030398	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P00012	Cadherin signaling pathway	P00477	GSK3beta	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00029	Huntington disease	P00807	Actin	MOUSE|MGI=MGI=2444552|UniProtKB=Q8BFZ3	Beta-actin-like protein 2	IDA	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00049	Parkinson disease	P01236	Casein kinase II	YEAST|SGD=S000002987|UniProtKB=P43639	Casein kinase II subunit beta	IDA	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00035	Interferon-gamma signaling pathway	P00956	SOCS	MACMU|Ensembl=ENSMMUG00000020531|UniProtKB=F7D8G7	Uncharacterized protein	ISS	12645661	PubMed	PTHR45052:SF1	SUPPRESSOR OF CYTOKINE SIGNALING 7
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT5G19010|UniProtKB=Q8W4J2	Mitogen-activated protein kinase 16	ISS			PTHR24055:SF211	MITOGEN-ACTIVATED PROTEIN KINASE 16
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	SCHPO|PomBase=SPAC6G9.11|UniProtKB=Q92356	Synaptobrevin homolog 1	IC			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	YEAST|SGD=S000001259|UniProtKB=P38697	Inosine-5'-monophosphate dehydrogenase 2	ISS			PTHR11911:SF111	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00029	Huntington disease	G01531	BDNF	PANTR|Ensembl=ENSPTRG00000028696|UniProtKB=Q5IS78	Brain-derived neurotrophic factor	ISS	11724916	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00049	Parkinson disease	P01240	hSel10	MACMU|Ensembl=ENSMMUG00000020330|UniProtKB=F6WGU1	F-box/WD repeat-containing protein 7 isoform 1	RCA			PTHR44007:SF6	F-BOX/WD REPEAT-CONTAINING PROTEIN 7
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04393	Ras Pathway	P04558	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	IDA	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00018	EGF receptor signaling pathway	P00559	MEK1-2	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IDA	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00045	Notch signaling pathway	P01119	NIct	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00034	Integrin signalling pathway	P00951	Jnk	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IDA	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00049	Parkinson disease	P01236	Casein kinase II	DANRE|ZFIN=ZDB-GENE-990415-29|UniProtKB=Q91398	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00058	mRNA splicing	P01476	U4	MONDO|Ensembl=ENSMODG00000018774|UniProtKB=F7ADZ9	Uncharacterized protein	ISS	12875835	PubMed	PTHR14212:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00048	PI3 kinase pathway	P01177	P110ACT	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	SCHPO|PomBase=SPBC8D2.01|UniProtKB=Q9URT9	Protein kinase gsk31	TAS			PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00036	Interleukin signaling pathway	P00972	MNK1/2	BOVIN|Ensembl=ENSBTAG00000018049|UniProtKB=E1BCH7	Uncharacterized protein	ISS	11463832	PubMed	PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	HUMAN|HGNC=237|UniProtKB=O43306	Adenylate cyclase type 6	IC	2491850	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00049	Parkinson disease	P01211	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02781	Threonine biosynthesis	P03189	Aspartate kinase	BACTN|EnsemblGenome=BT_2403|UniProtKB=Q8A541	Aspartokinase/homoserine dehydrogenase	ISS			PTHR21499:SF3	ASPARTOKINASE
P00006	Apoptosis signaling pathway	P00274	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	TAKRU|Ensembl=ENSTRUG00000011517|UniProtKB=H2TWL9	Uncharacterized protein (Fragment)	ISS	12497607	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00048	PI3 kinase pathway	P01192	p110	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	IGI	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00034	Integrin signalling pathway	P00951	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01199	Galpha	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CHICK|Gene=CHRNB4|UniProtKB=P26153	Neuronal acetylcholine receptor subunit beta-4 (Fragment)	IC	22213672	PubMed	PTHR18945:SF385	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-4
P00029	Huntington disease	G01531	BDNF	HUMAN|HGNC=1033|UniProtKB=P23560	Brain-derived neurotrophic factor	ISS	12117585	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05916	Opioid prodynorphin pathway	P06002	G-protein	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	LEIMA|EnsemblGenome=LmjF.18.1080|UniProtKB=Q27687	Protein kinase A catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05918	p38 MAPK pathway	P06020	p38delta	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	RCA	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05938	RhoA	XENTR|Xenbase=XB-GENE-489222|UniProtKB=Q28GJ8	Ras homolog gene family, member A	ISS	15668138	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	RCA	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00018	EGF receptor signaling pathway	P00547	PP2A	TAKRU|Ensembl=ENSTRUG00000011169|UniProtKB=H2TU36	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	21186066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MOUSE|MGI=MGI=87904|UniProtKB=P60710	Actin, cytoplasmic 1	IC	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MACMU|Ensembl=ENSMMUG00000009679|UniProtKB=F6YBQ8	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CHICK|Ensembl=ENSGALG00000001172|UniProtKB=P19439	Probable glutamate receptor	ISS	12941441	PubMed	PTHR18966:SF282	GLUTAMATE RECEPTOR-RELATED
P00037	Ionotropic glutamate receptor pathway	P01020	NSF	PANTR|Ensembl=ENSPTRG00000009320|UniProtKB=H2QD95	N-ethylmaleimide-sensitive factor	ISS	601633	OMIM	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00059	p53 pathway	P01485	p53	MACMU|Ensembl=ENSMMUG00000016569|UniProtKB=F6VXE7	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00014	Cholesterol biosynthesis	P00498	Hydroxymethyl glutaryl CoA synthase	PANTR|Ensembl=ENSPTRG00000016845|UniProtKB=H2QQU5	3-hydroxy-3-methylglutaryl-CoA synthase 1 (Soluble)	ISS	600234	OMIM	PTHR43323:SF4	HYDROXYMETHYLGLUTARYL-COA SYNTHASE, CYTOPLASMIC
P00054	Toll receptor signaling pathway	P01352	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MACMU|Ensembl=ENSMMUG00000021442|UniProtKB=F7EAQ8	Muscarinic acetylcholine receptor	ISS	10069496	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P02738	De novo purine biosynthesis	P02908	Phosphoribosylamine glycine ligase	YEAST|SGD=S000003203|UniProtKB=P07244	Bifunctional purine biosynthetic protein ADE5,7	ISS			PTHR10520:SF10	TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3
P05913	Enkephalin release	P05977	G-Protein (s)	MONDO|Ensembl=ENSMODG00000000771|UniProtKB=F6SSS3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P02751	Lysine biosynthesis	P03008	Dihydrodipicolinate synthase	HALSA|EnsemblGenome=VNG_0444G|UniProtKB=Q9HS19	Uncharacterized DapA-like lyase VNG_0444G	ISS			PTHR12128:SF15	4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL
P00019	Endothelin signaling pathway	P00587	Raf-1	TAKRU|Ensembl=ENSTRUG00000006611|UniProtKB=H2SV11	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00951	Jnk	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	IDA	11707292	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04393	Ras Pathway	P04547	Ras	DAPPU|EnsemblGenome=DAPPUDRAFT_301818|UniProtKB=E9I1I7	Putative uncharacterized protein	ISS	10684567	PubMed	PTHR24070:SF385	GTPASE HRAS
P00048	PI3 kinase pathway	P01179	PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00078	Alpha1A/1B/1C	MACMU|Ensembl=ENSMMUG00000011842|UniProtKB=G7NAM7	Uncharacterized protein	ISS	6323229	PubMed	PTHR24248:SF26	ALPHA-2B ADRENERGIC RECEPTOR
P00021	FGF signaling pathway	P00632	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01159	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P06664	Gonadotropin-releasing hormone receptor pathway	P06752	BMP6/7	MOUSE|MGI=MGI=103302|UniProtKB=P23359	Bone morphogenetic protein 7	RCA	9759503	PubMed	PTHR11848:SF135	BONE MORPHOGENETIC PROTEIN 7
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00391	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00022	General transcription by RNA polymerase I	P00657	TBP	MONDO|Ensembl=ENSMODG00000017515|UniProtKB=F7F0J5	Uncharacterized protein	ISS	10082669	PubMed	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00005	Angiogenesis	P00203	Erk	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000008270|UniProtKB=H2QBE5	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF319	CADHERIN-1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	SCHMA|EnsemblGenome=Smp_079970|UniProtKB=G4VTA5	Putative tubulin beta chain	ISS	9454836	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01092	delta	MACMU|Ensembl=ENSMMUG00000022147|UniProtKB=F7H3A4	Uncharacterized protein	ISS	85203892	PubMed	PTHR18945:SF61	ACETYLCHOLINE RECEPTOR SUBUNIT DELTA
P00010	B cell activation	P00371	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00047	PDGF signaling pathway	P01154	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P00021	FGF signaling pathway	P00627	ERK1-2	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00046	Oxidative stress response	P01126	ATF2	MONDO|Ensembl=ENSMODG00000009514|UniProtKB=F7EVK3	Uncharacterized protein	ISS	10487205	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00021	FGF signaling pathway	P00627	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	21071228	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04395	Vasopressin synthesis	P04596	Endo Peptidase	DROME|FlyBase=FBgn0032969|UniProtKB=Q9V9P5	CG2528, isoform E	IC	9695945	PubMed	PTHR42881:SF2	PROLYL ENDOPEPTIDASE
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	CANLF|Gene=FZD6|UniProtKB=Q8WMU5	Frizzled-6	TAS	8717036	PubMed	PTHR11309:SF75	FRIZZLED-6
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00010	B cell activation	P00379	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00009	Axon guidance mediated by netrin	P00357	Netrin	MOUSE|MGI=MGI=1888978|UniProtKB=Q9JI33	Netrin-4	ISS	2538453	PubMed	PTHR10574:SF282	NETRIN-4
P00029	Huntington disease	P00775	Rac	ENTHI|EnsemblGenome=EHI_197840|UniProtKB=C4M8K6	Rho family GTPase	TAS			PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00036	Interleukin signaling pathway	P00965	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IC	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00207	Crk	MOUSE|MGI=MGI=88508|UniProtKB=Q64010	Adapter molecule crk	ISS	8649368	PubMed	PTHR19969:SF8	ADAPTER MOLECULE CRK
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00047	PDGF signaling pathway	P01175	Shc	HUMAN|HGNC=29869|UniProtKB=P98077	SHC-transforming protein 2	ISS	10749680	PubMed	PTHR10337:SF5	SHC-TRANSFORMING PROTEIN 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	RAT|RGD=70994|UniProtKB=Q05096	Unconventional myosin-Ib	IC			PTHR13140:SF277	UNCONVENTIONAL MYOSIN-IB
P00019	Endothelin signaling pathway	P00566	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IGI	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	IC	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CAEEL|WormBase=WBGene00006454|UniProtKB=G5EEN8	AEX-4	ISS			PTHR19305:SF10	AEX-4
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00018	EGF receptor signaling pathway	P00564	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00018	EGF receptor signaling pathway	P00545	JNK1-3	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS			PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	CANLF|Gene=ADCY6|UniProtKB=P30804	Adenylate cyclase type 6	IC	92409599	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00035	Interferon-gamma signaling pathway	P00958	PIAS	MACMU|Ensembl=ENSMMUG00000016733|UniProtKB=F6V666	Uncharacterized protein	ISS	8682149	PubMed	PTHR10782:SF10	E3 SUMO-PROTEIN LIGASE PIAS3
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	IPI	12701063	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00047	PDGF signaling pathway	P01172	c-Myc	ORNAN|Ensembl=ENSOANG00000022610|UniProtKB=F6XRU8	Uncharacterized protein	ISS	15094771	PubMed	PTHR13168:SF0	C-MYC-BINDING PROTEIN
P00030	Hypoxia response via HIF activation	P00825	Thioredoxin	BOVIN|Gene=TXN|UniProtKB=O97680	Thioredoxin	ISS	12115731	PubMed	PTHR10438:SF18	THIOREDOXIN
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	CHICK|Gene=FYN|UniProtKB=Q05876	Tyrosine-protein kinase Fyn	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00016	Cytoskeletal regulation by Rho GTPase	P00520	Rho GAPs	MOUSE|MGI=MGI=2445003|UniProtKB=Q5FWK3	Rho GTPase-activating protein 1	ISS	14724572	PubMed	PTHR23176:SF28	RHO GTPASE-ACTIVATING PROTEIN 1
P00053	T cell activation	P01332	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04542	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02740	De novo pyrimidine ribonucleotides biosythesis	P02927	Dihydrooratate oxidase	LEIMA|EnsemblGenome=LmjF.16.0530|UniProtKB=Q4QEW7	Dihydroorotate dehydrogenase	ISS			PTHR43843:SF1	DIHYDROOROTATE DEHYDROGENASE  FUMARATE
P00057	Wnt signaling pathway	P01451	Galpha	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00047	PDGF signaling pathway	P01159	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00181	SHP2	MACMU|Ensembl=ENSMMUG00000013253|UniProtKB=F6ZJD8	Tyrosine-protein phosphatase non-receptor type	ISS	14534538	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00029	Huntington disease	P00786	ARF	CANLF|Ensembl=ENSCAFG00000010433|UniProtKB=E2RNQ7	Uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF294	ADP-RIBOSYLATION FACTOR 3
P00013	Cell cycle	P00481	APC	HUMAN|HGNC=24077|UniProtKB=Q9UM13	Anaphase-promoting complex subunit 10	ISS	7657035	gi	PTHR12936:SF0	ANAPHASE-PROMOTING COMPLEX SUBUNIT 10
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	94280860	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	20027584	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	RAT|RGD=629471|UniProtKB=O70521	Regulator of G-protein signaling 19	IDA	8756726	PubMed	PTHR10845:SF145	REGULATOR OF G-PROTEIN SIGNALING 19
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CAEBR|Gene=CBG23091|UniProtKB=A8Y4Q9	Protein CBR-ACT-2	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02779	Thiamin biosynthesis	P03175	1-Deoxyxylulose-5-phosphate synthase	STRCO|EnsemblGenome=CAD55365|UniProtKB=Q8CJP7	1-deoxy-D-xylulose-5-phosphate synthase 2	ISS			PTHR43322:SF6	1-DEOXY-D-XYLULOSE-5-PHOSPHATE SYNTHASE
P04398	p53 pathway feedback loops 2	P04658	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00048	PI3 kinase pathway	P01188	Gbetagamma	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	RCA	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00054	Toll receptor signaling pathway	P01358	ERK1	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	SCHMA|EnsemblGenome=Smp_161920|UniProtKB=G4VSW5	Putative actin	IDA	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00035	Interferon-gamma signaling pathway	P00961	STAT1	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	TAS	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00029	Huntington disease	P00775	Rac	CAEEL|WormBase=WBGene00000424|UniProtKB=Q03206	Ras-related protein ced-10	TAS			PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	CHICK|Ensembl=ENSGALG00000016226|UniProtKB=E1BWL4	Uncharacterized protein	ISS	11679592	PubMed	PTHR23122:SF40	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P00010	B cell activation	P00375	Calmodulin	CANLF|Ensembl=ENSCAFG00000016335|UniProtKB=J9NXY2	Uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF322	SUBFAMILY NOT NAMED
P00054	Toll receptor signaling pathway	P01340	TLR3	HUMAN|HGNC=11849|UniProtKB=O15455	Toll-like receptor 3	ISS			PTHR44599:SF1	TOLL-LIKE RECEPTOR 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00048	PI3 kinase pathway	P01192	p110	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05913	Enkephalin release	P05972	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02761	Pantothenate biosynthesis	P03068	Pantoate-beta-alanine ligase	BACTN|EnsemblGenome=BT_4308|UniProtKB=Q89ZR8	Pantothenate synthetase	ISS			PTHR21299:SF1	PANTOATE--BETA-ALANINE LIGASE
P00056	VEGF signaling pathway	P01403	VEGFR-2	CHICK|Ensembl=ENSGALG00000005802|UniProtKB=F1N871	Uncharacterized protein	ISS			PTHR24416:SF49	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 3
P00021	FGF signaling pathway	P00645	Rac	DICDI|dictyBase=DDB_G0268622|UniProtKB=P34145	Rho-related protein rac1B	ISS	4757952	gi	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	RAT|RGD=3425|UniProtKB=P97887	Presenilin-1	IDA	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P05912	Dopamine receptor mediated signaling pathway	P05957	K+ channel	PANTR|Ensembl=ENSPTRG00000020614|UniProtKB=H2QWR7	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00034	Integrin signalling pathway	P00922	Collagen	MACMU|Ensembl=ENSMMUG00000014049|UniProtKB=F7AG82	Uncharacterized protein	ISS	10778855	PubMed	PTHR44105:SF2	COLLAGEN ALPHA-3 VI  CHAIN
P00056	VEGF signaling pathway	P01410	Caspase9	HUMAN|HGNC=1511|UniProtKB=P55211	Caspase-9	IDA	8663294	PubMed	PTHR10454:SF157	CASPASE-9
P00021	FGF signaling pathway	P00627	ERK1-2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IGI	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00034	Integrin signalling pathway	P00940	Src	MOUSE|MGI=MGI=103265|UniProtKB=Q922K9	Tyrosine-protein kinase FRK	IPI	9013950	PubMed	PTHR24418:SF296	TYROSINE-PROTEIN KINASE FRK
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	DANRE|ZFIN=ZDB-GENE-040426-59|UniProtKB=Q6P045	Tyms protein	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00005	Angiogenesis	P00256	PLC-gamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	PANTR|Ensembl=ENSPTRG00000008411|UniProtKB=H2QBM1	Uncharacterized protein	ISS	20355009	PubMed	PTHR15319:SF1	TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT C
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00760	Gtalpha	CANLF|Ensembl=ENSCAFG00000010764|UniProtKB=Q28300	Guanine nucleotide-binding protein G(t) subunit alpha-1	IDA	10188796	PubMed	PTHR10218:SF67	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-1
P00029	Huntington disease	P00797	p53	CAEEL|WormBase=WBGene00001579|UniProtKB=O44518	Cytoplasmic FMR1-interacting protein homolog	TAS			PTHR12195:SF0	CYTOPLASMIC FMR1-INTERACTING PROTEIN
P00014	Cholesterol biosynthesis	P00498	Hydroxymethyl glutaryl CoA synthase	ANOGA|EnsemblGenome=AGAP005847|UniProtKB=Q7Q6H2	AGAP005847-PA	ISS			PTHR43323:SF2	HMG COENZYME A SYNTHASE, ISOFORM A
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1354946|UniProtKB=Q61532	Mitogen-activated protein kinase 6	IDA	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00778	NMDA receptor	DROME|FlyBase=FBgn0010399|UniProtKB=Q24418	Glutamate [NMDA] receptor subunit 1	IDA	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00012	Cadherin signaling pathway	P00474	Wnt	DROME|FlyBase=FBgn0004360|UniProtKB=P28465	Protein Wnt-2	IDA	11266476	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00095	Nicastrin	DROME|FlyBase=FBgn0039234|UniProtKB=Q9VC27	Nicastrin	IDA	16096062	PubMed	PTHR21092:SF0	NICASTRIN
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00053	T cell activation	P01322	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02753	Methionine biosynthesis	P03024	Homocysteine transmethylase	THEMA|EnsemblGenome=TM_0268|UniProtKB=Q9WYA5	5-methyltetrahydrofolate S-homocysteine methyltransferase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P00034	Integrin signalling pathway	P00913	Csk	CANLF|Ensembl=ENSCAFG00000017945|UniProtKB=E2RFF7	Tyrosine-protein kinase	ISS	12665526	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00021	FGF signaling pathway	P00633	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01286	TGFbeta	PANTR|Ensembl=ENSPTRG00000016577|UniProtKB=H2QQE4	Metalloendopeptidase	ISS	9759503	PubMed	PTHR43978:SF4	TOLLOID-LIKE PROTEIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=619745|UniProtKB=Q8R490	Cadherin 13	IDA	8120095	PubMed	PTHR24027:SF80	CADHERIN-13
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00020	FAS signaling pathway	P00615	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00010	B cell activation	P00401	jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00049	Parkinson disease	P01234	GRK	PANTR|Ensembl=ENSPTRG00000003946|UniProtKB=H2Q482	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00034	Integrin signalling pathway	P00917	ELMO	CANLF|Ensembl=ENSCAFG00000010313|UniProtKB=E2RF34	Uncharacterized protein	ISS	12879077	PubMed	PTHR12771:SF8	ENGULFMENT AND CELL MOTILITY PROTEIN 2
P00019	Endothelin signaling pathway	P00568	PKC	SCHPO|PomBase=SPBC12D12.04c|UniProtKB=P36583	Protein kinase C-like 2	IGI	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04398	p53 pathway feedback loops 2	P04665	AKT	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01182	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05925	beta-ARR1	HUMAN|HGNC=711|UniProtKB=P49407	Beta-arrestin-1	RCA	9388255	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	HUMAN|HGNC=6694|UniProtKB=P98164	Low-density lipoprotein receptor-related protein 2	IDA	11907044	PubMed	PTHR44025:SF5	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2
P00021	FGF signaling pathway	P00642	MEK1-2	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	HUMAN|HGNC=4588|UniProtKB=O15399	Glutamate receptor ionotropic, NMDA 2D	ISS	11319238	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05915	Opioid proenkephalin pathway	P05991	Enkephalin	DANRE|ZFIN=ZDB-GENE-030729-3|UniProtKB=F1QTD1	Uncharacterized protein (Fragment)	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01151	PKB	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00636	FGFR1-4	CHICK|Gene=FGFR1|UniProtKB=P21804	Fibroblast growth factor receptor 1	IPI	2544996	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	PANTR|Ensembl=ENSPTRG00000017291|UniProtKB=H2QRK9	Catenin (Cadherin-associated protein), alpha 1, 102kDa	ISS	1904011	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=37295|UniProtKB=A4D2H0	cTAGE family member 15	IC			PTHR23158:SF53	CTAGE FAMILY MEMBER 15-RELATED
P00030	Hypoxia response via HIF activation	P00824	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	TAS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	MOUSE|MGI=MGI=103301|UniProtKB=Q8R0S4	Voltage-dependent L-type calcium channel subunit beta-4	IC			PTHR11824:SF7	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_58093|UniProtKB=C3Z4K3	Putative uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04574	PLD	MACMU|Ensembl=ENSMMUG00000023289|UniProtKB=F7FFD2	Uncharacterized protein	ISS	15668389	PubMed	PTHR18896:SF57	PHOSPHOLIPASE D1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00019	Endothelin signaling pathway	P00590	IP3 R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02759	Pyridoxal-5-phosphate biosynthesis	P03062	1-Deoxyxylulose-5-phosphate synthase	CHLTR|EnsemblGenome=CT_331|UniProtKB=O84335	1-deoxy-D-xylulose-5-phosphate synthase	ISS			PTHR43322:SF6	1-DEOXY-D-XYLULOSE-5-PHOSPHATE SYNTHASE
P00015	Circadian clock system	P00504	Per	DANRE|ZFIN=ZDB-GENE-011220-2|UniProtKB=F1QUT1	Uncharacterized protein	ISS	15763996	PubMed	PTHR11269:SF9	PERIOD CIRCADIAN PROTEIN HOMOLOG 2
P00005	Angiogenesis	P00234	Grb2	HUMAN|HGNC=4562|UniProtKB=Q13588	GRB2-related adapter protein	ISS			PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00285	Diva	PANTR|Ensembl=ENSPTRG00000007083|UniProtKB=H2Q9G4	Uncharacterized protein	ISS	11557035	PubMed	PTHR11256:SF47	BCL-2-LIKE PROTEIN 10
P00029	Huntington disease	P00805	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	DANRE|ZFIN=ZDB-GENE-020125-4|UniProtKB=F1QKT1	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00047	PDGF signaling pathway	P01154	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01437	TCF	BOVIN|Ensembl=ENSBTAG00000006844|UniProtKB=E1BJ93	Uncharacterized protein	ISS	9039917	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00055	Transcription regulation by bZIP transcription factor	P01395	TFIIE	HUMAN|HGNC=4650|UniProtKB=P29083	General transcription factor IIE subunit 1	ISS	189964	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00005	Angiogenesis	P00243	Raf	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS	12068308	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00628	JNK1-3	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	DANRE|ZFIN=ZDB-GENE-031117-1|UniProtKB=A4FTT3	Rbpja protein	ISS	9043084	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	DANRE|ZFIN=ZDB-GENE-991119-4|UniProtKB=Q9W6T7	Presenilin-1	IDA	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P05731	GABA-B receptor II signaling	P05755	Gbeta	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	RCA	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P02759	Pyridoxal-5-phosphate biosynthesis	P03061	Pyridoxine-5-phosphate oxidase	PANTR|Ensembl=ENSPTRG00000009343|UniProtKB=H2QDB2	Pyridoxamine 5'-phosphate oxidase	ISS	14697241	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CHICK|Ensembl=ENSGALG00000027629|UniProtKB=Q5ZJ03	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04393	Ras Pathway	P04542	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	RAT|RGD=619965|UniProtKB=P26769	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00017	DNA replication	P00530	Top	MACMU|Ensembl=ENSMMUG00000011112|UniProtKB=F6TZC2	Uncharacterized protein	RCA			PTHR10290:SF5	DNA TOPOISOMERASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00053	T cell activation	P01311	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05915	Opioid proenkephalin pathway	P05994	G-protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00053	T cell activation	P01336	Jnk	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00060	Ubiquitin proteasome pathway	P01491	E2	SCHPO|PomBase=SPBC2D10.20|UniProtKB=O74810	Ubiquitin-conjugating enzyme E2 1	ISS			PTHR44020:SF2	UBIQUITIN-CONJUGATING ENZYME E2 K
P00005	Angiogenesis	P00243	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00014	Cholesterol biosynthesis	P00500	Phosphomevalonate kinase	DROME|FlyBase=FBgn0032811|UniProtKB=Q9VIT2	Probable phosphomevalonate kinase	ISS			PTHR13101:SF1	PHOSPHOMEVALONATE KINASE
P00035	Interferon-gamma signaling pathway	P00961	STAT1	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	TAS	12191995	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00012	Cadherin signaling pathway	P00470	F-actin	SCHPO|PomBase=SPBC32H8.12c|UniProtKB=P10989	Actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00018	EGF receptor signaling pathway	P00540	MKK3,6	HUMAN|HGNC=6843|UniProtKB=P46734	Dual specificity mitogen-activated protein kinase kinase 3	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P02775	Salvage pyrimidine ribonucleotides	P03155	Cytosine deaminase	DROME|FlyBase=FBgn0038491|UniProtKB=Q9VEM0	CG5292, isoform A	ISS			PTHR11079:SF92	TRNA-SPECIFIC ADENOSINE DEAMINASE 2
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	MOUSE|MGI=MGI=94924|UniProtKB=P61168	D(2) dopamine receptor	ISS	11861492	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00054	Toll receptor signaling pathway	P01352	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00029	Huntington disease	P00801	Fos protein	CANLF|Ensembl=ENSCAFG00000017040|UniProtKB=E2QYK5	Uncharacterized protein	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00057	Wnt signaling pathway	P01440	Cadherin	CANLF|Ensembl=ENSCAFG00000004944|UniProtKB=F1P7Y5	Uncharacterized protein	ISS	8120095	PubMed	PTHR43912:SF5	PROTOCADHERIN-9
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MACMU|Ensembl=ENSMMUG00000032222|UniProtKB=F7FW05	Uncharacterized protein	ISS	11701344	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00021	FGF signaling pathway	P00629	PP2A	ARATH|TAIR=AT3G19980|UniProtKB=Q9LHE7	Phytochrome-associated serine/threonine-protein phosphatase 3	ISS			PTHR11668:SF24	SERINE/THREONINE-PROTEIN PHOSPHATASE 6 CATALYTIC SUBUNIT
P05918	p38 MAPK pathway	P06034	MKK4	MOUSE|MGI=MGI=1346869|UniProtKB=P47809	Dual specificity mitogen-activated protein kinase kinase 4	RCA	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00053	T cell activation	P01336	Jnk	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00006	Apoptosis signaling pathway	P00316	Bcl-w	MOUSE|MGI=MGI=108052|UniProtKB=P70345	Bcl-2-like protein 2	ISS	8761287	PubMed	PTHR11256:SF13	BCL-2-LIKE PROTEIN 2
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00645	Rac	ENTHI|EnsemblGenome=EHI_181250|UniProtKB=C4M5Z7	Rho family GTPase	ISS	8649368	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00018	EGF receptor signaling pathway	P00555	MKK4,7	DROME|FlyBase=FBgn0010303|UniProtKB=Q23977	Dual specificity mitogen-activated protein kinase kinase hemipterous	ISS			PTHR24361:SF387	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00029	Huntington disease	P00810	GAPDH	PANTR|Ensembl=ENSPTRG00000010848|UniProtKB=H2QG30	Glyceraldehyde-3-phosphate dehydrogenase	ISS			PTHR10836:SF79	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE, TESTIS-SPECIFIC
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DICDI|dictyBase=DDB_G0279413|UniProtKB=P05987	cAMP-dependent protein kinase regulatory subunit	IC	91298951	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	DROME|FlyBase=FBgn0001145|UniProtKB=P20478	Glutamine synthetase 2 cytoplasmic	ISS			PTHR20852:SF57	GLUTAMINE SYNTHETASE 2 CYTOPLASMIC
P05734	Synaptic vesicle trafficking	P05777	Synaptophysin	BOVIN|Gene=SYP|UniProtKB=P20488	Synaptophysin	ISS	313475	OMIM	PTHR10306:SF10	SYNAPTOPHYSIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MOUSE|MGI=MGI=97359|UniProtKB=P43021	Nodal	TAS	9759503	PubMed	PTHR11848:SF159	NODAL HOMOLOG
P00059	p53 pathway	P04610	Cyclin E	DANRE|ZFIN=ZDB-GENE-980526-168|UniProtKB=P47794	G1/S-specific cyclin-E1	NAS	12628165	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00009	Axon guidance mediated by netrin	P00357	Netrin	RAT|RGD=619811|UniProtKB=G3V6X3	Netrin 2-like (Chicken)	ISS			PTHR10574:SF292	NETRIN-3
P00056	VEGF signaling pathway	P01420	FAK	RAT|RGD=3443|UniProtKB=O35346	Focal adhesion kinase 1	ISS	12640026	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT4G01370|UniProtKB=Q39024	Mitogen-activated protein kinase 4	ISS	10851062	PubMed	PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P00047	PDGF signaling pathway	P01167	Ets	HUMAN|HGNC=3488|UniProtKB=P14921	Protein C-ets-1	ISS	3060801	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00049	Parkinson disease	P01241	TH	HUMAN|HGNC=11782|UniProtKB=P07101	Tyrosine 3-monooxygenase	TAS	12480184	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	HUMAN|HGNC=7883|UniProtKB=Q9UM47	Neurogenic locus notch homolog protein 3	IDA	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00021	FGF signaling pathway	P00648	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00006	Apoptosis signaling pathway	P00274	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	TAKRU|Ensembl=ENSTRUG00000015959|UniProtKB=H2UV27	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00044	Nicotinic acetylcholine receptor signaling pathway	P01087	CAT	ANOGA|EnsemblGenome=AGAP002370|UniProtKB=Q7QBZ0	AGAP002370-PA (Fragment)	IC	92155737	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P00012	Cadherin signaling pathway	P00476	Yes	HUMAN|HGNC=12841|UniProtKB=P07947	Tyrosine-protein kinase Yes	ISS	11078745	PubMed	PTHR24418:SF90	TYROSINE-PROTEIN KINASE YES
P00029	Huntington disease	P00809	Caspase 6	RAT|RGD=70967|UniProtKB=O35397	Caspase-6	ISS	11463840	PubMed	PTHR10454:SF164	CASPASE-6
P00019	Endothelin signaling pathway	P00587	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	RAT|RGD=2868|UniProtKB=P08025	Insulin-like growth factor I	ISS			PTHR11454:SF4	INSULIN-LIKE GROWTH FACTOR I
P00019	Endothelin signaling pathway	P00590	IP3 R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P02736	Coenzyme A biosynthesis	P02886	Pantetheine-phosphate adenyltransferase	THEMA|EnsemblGenome=TM_0741|UniProtKB=Q9WZK0	Phosphopantetheine adenylyltransferase	ISS			PTHR21342:SF1	PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE
P00021	FGF signaling pathway	P00629	PP2A	XENTR|Xenbase=XB-GENE-946380|UniProtKB=Q0D2F4	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform	ISS	12110603	PubMed	PTHR11871:SF1	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B BETA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6879|UniProtKB=Q16659	Mitogen-activated protein kinase 6	ISS	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00056	VEGF signaling pathway	P01409	cPLA2	PANTR|Ensembl=ENSPTRG00000001787|UniProtKB=H2Q0T0	Phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00006	Apoptosis signaling pathway	P00260	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	YEAST|SGD=S000003666|UniProtKB=P07259	Protein URA2	ISS			PTHR11405:SF5	CAD PROTEIN
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	TRIVA|Gene=TVAG_034440|UniProtKB=A2EM81	Beta-tubulin, putative	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00057	Wnt signaling pathway	P01428	Frizzled	CANLF|Ensembl=ENSCAFG00000008293|UniProtKB=E2R9M9	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF22	FRIZZLED-3
P00048	PI3 kinase pathway	P01188	Gbetagamma	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00018	EGF receptor signaling pathway	P00551	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	PANTR|Ensembl=ENSPTRG00000001792|UniProtKB=H2Q0T4	Regulator of G-protein signaling 2, 24kDa	ISS	8756726	PubMed	PTHR10845:SF43	REGULATOR OF G-PROTEIN SIGNALING 2
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IGI	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00005	Angiogenesis	P00256	PLC-gamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00034	Integrin signalling pathway	P00925	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	IDA	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00049	Parkinson disease	P01212	p38 MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00627	ERK1-2	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	97442349	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05730	Endogenous cannabinoid signaling	P05748	mGluR	MACMU|Ensembl=ENSMMUG00000010184|UniProtKB=F6SR09	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00012	Cadherin signaling pathway	P00474	Wnt	RAT|RGD=621463|UniProtKB=G3V819	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01454	betaTrCP	CHICK|Ensembl=ENSGALG00000002229|UniProtKB=F1P5E8	Uncharacterized protein	ISS	12628165	PubMed	PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	TAS	11707292	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000005917|UniProtKB=F6QM53	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	DANRE|ZFIN=ZDB-GENE-991119-4|UniProtKB=Q9W6T7	Presenilin-1	TAS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00025	Hedgehog signaling pathway	P00682	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00034	Integrin signalling pathway	P00906	Rap1	DICPU|Gene=DICPUDRAFT_59134|UniProtKB=F1A4I5	Putative uncharacterized protein rapA	ISS	8576107	PubMed	PTHR24070:SF263	RAS-LIKE PROTEIN 3
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	DEIRA|EnsemblGenome=DR_2268|UniProtKB=Q9RS59	Aminotransferase, class I	ISS			PTHR42832:SF2	SUBFAMILY NOT NAMED
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MONDO|Ensembl=ENSMODG00000001775|UniProtKB=F6WJB1	Uncharacterized protein	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	15572354	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00006	Apoptosis signaling pathway	P00307	ELF2alpha	SCHPO|PomBase=SPAC3G9.09c|UniProtKB=P56286	Eukaryotic translation initiation factor 2 subunit alpha	ISS			PTHR10602:SF0	EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1
P04393	Ras Pathway	P04572	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00016	Cytoskeletal regulation by Rho GTPase	P00521	Profilin	MOUSE|MGI=MGI=2178800|UniProtKB=Q9DAD6	Profilin-3	ISS			PTHR13936:SF2	PROFILIN-3
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=12786|UniProtKB=O00755	Protein Wnt-7a	IDA	8717036	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00057	Wnt signaling pathway	P01443	Phospholipase C	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IDA	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	DAPPU|EnsemblGenome=DAPPUDRAFT_301818|UniProtKB=E9I1I7	Putative uncharacterized protein	ISS	10684567	PubMed	PTHR24070:SF385	GTPASE HRAS
P00034	Integrin signalling pathway	P00931	Integrin beta	MOUSE|MGI=MGI=96612|UniProtKB=O54890	Integrin beta-3	IDA	20069419	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g188243|UniProtKB=A7SCN8	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01098	CHT1	PANTR|Ensembl=ENSPTRG00000000978|UniProtKB=H2PZF6	Uncharacterized protein	ISS			PTHR12385:SF13	CHOLINE TRANSPORTER-LIKE PROTEIN 3
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	RAT|RGD=2738|UniProtKB=Q00960	Glutamate receptor ionotropic, NMDA 2B	IC	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IGI	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEEL|WormBase=WBGene00018620|UniProtKB=O44588	Uncharacterized protein	IC	15572354	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P00059	p53 pathway	G04693	WIP-1	MOUSE|MGI=MGI=1858214|UniProtKB=Q9QZ67	Protein phosphatase 1D	ISS			PTHR13832:SF359	PROTEIN PHOSPHATASE 1D
P00038	JAK/STAT signaling pathway	P01034	Jak	MOUSE|MGI=MGI=96628|UniProtKB=P52332	Tyrosine-protein kinase JAK1	ISS	11929133	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00006	Apoptosis signaling pathway	P00260	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00024	Glycolysis	P00679	Aldolase	MONDO|Ensembl=ENSMODG00000015696|UniProtKB=F7E0Q7	Fructose-bisphosphate aldolase	ISS	84261525	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	PANTR|Ensembl=ENSPTRG00000015475|UniProtKB=H2QNI2	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF12	RHODOPSIN KINASE
P00047	PDGF signaling pathway	P01143	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	CHICK|Ensembl=ENSGALG00000010273|UniProtKB=P48463	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00047	PDGF signaling pathway	P01168	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	ISS	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P05916	Opioid prodynorphin pathway	P06002	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	IGI	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P02751	Lysine biosynthesis	P03011	N-succinyldiaminopimelate  aminotransferase	LEPIN|EnsemblGenome=LA_2153|UniProtKB=P24087	Acetylornithine aminotransferase	IDA			PTHR11986:SF79	ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00035	Interferon-gamma signaling pathway	P00956	SOCS	MOUSE|MGI=MGI=2651588|UniProtKB=Q8VHQ2	Suppressor of cytokine signaling 7	TAS	15032587	PubMed	PTHR45052:SF1	SUPPRESSOR OF CYTOKINE SIGNALING 7
P00050	Plasminogen activating cascade	P01250	MMP-13	BOVIN|Gene=MMP13|UniProtKB=O77656	Collagenase 3	ISS	12834808	PubMed	PTHR10201:SF165	COLLAGENASE 3
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05918	p38 MAPK pathway	P06023	MEF	HUMAN|HGNC=6996|UniProtKB=Q06413	Myocyte-specific enhancer factor 2C	RCA	11274345	PubMed	PTHR11945:SF25	MYOCYTE-SPECIFIC ENHANCER FACTOR 2C
P00054	Toll receptor signaling pathway	P01352	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000000365|UniProtKB=F6R9F4	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DANRE|ZFIN=ZDB-GENE-030131-55|UniProtKB=Q6XNL8	Actin	IC	11889126	PubMed	PTHR11937:SF263	ACTIN
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00047	PDGF signaling pathway	P01143	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00269	MAPK	ORYSJ|EnsemblGenome=OS02G0148100|UniProtKB=Q6Z437	Mitogen-activated protein kinase 3	ISS	12787066	PubMed	PTHR24055:SF216	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01451	Galpha	RAT|RGD=619751|UniProtKB=O88302	Guanine nucleotide-binding protein subunit alpha-15	IDA	10629036	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	HUMAN|HGNC=143|UniProtKB=P68032	Actin, alpha cardiac muscle 1	IC	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00049	Parkinson disease	P01212	p38 MAPK	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	NAS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04392	P53 pathway feedback loops 1	P04540	Cop-1	ORNAN|Ensembl=ENSOANG00000000942|UniProtKB=F6PJK3	Uncharacterized protein	ISS	15103385	PubMed	PTHR44080:SF1	E3 UBIQUITIN-PROTEIN LIGASE RFWD2
P00047	PDGF signaling pathway	P01153	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	TAS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	CHICK|Ensembl=ENSGALG00000011699|UniProtKB=F1NEC3	Uncharacterized protein	IC	2491850	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MOUSE|MGI=MGI=1309999|UniProtKB=Q922R0	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00014	Cholesterol biosynthesis	P00495	Isopentenyl diphosphate delta-isomerase	PANTR|Ensembl=ENSPTRG00000002237|UniProtKB=H2Q1J1	Uncharacterized protein	ISS	6225528	gi	PTHR10885:SF1	ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE 2
P00013	Cell cycle	P00480	Proteasome	HUMAN|HGNC=9556|UniProtKB=O00231	26S proteasome non-ATPase regulatory subunit 11	ISS	97227943	PubMed	PTHR10678:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	IDA	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05913	Enkephalin release	P05974	G-Protein (i)	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	8327893	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000022513|UniProtKB=F6YNZ0	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	TAS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00012	Cadherin signaling pathway	P00474	Wnt	BOVIN|Ensembl=ENSBTAG00000012914|UniProtKB=F1MHG3	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05916	Opioid prodynorphin pathway	P05999	provasopressin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IDA	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P02778	Sulfate assimilation	P03167	Sulfate adenylyltransferase	SYNY3|EnsemblGenome=BAA18335|UniProtKB=P74241	Sulfate adenylyltransferase	ISS			PTHR43509:SF1	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00629	PP2A	CHICK|Ensembl=ENSGALG00000011260|UniProtKB=Q5F3C6	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P00012	Cadherin signaling pathway	P00466	EGFR	CANLF|Gene=ERBB2|UniProtKB=O18735	Receptor tyrosine-protein kinase erbB-2	ISS	4758298	gi	PTHR24416:SF137	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00776	c-Jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00018	EGF receptor signaling pathway	P00544	c-Cbl	BOVIN|Ensembl=ENSBTAG00000013057|UniProtKB=F1N510	Uncharacterized protein	ISS	95303504	PubMed	PTHR23007:SF3	E3 UBIQUITIN-PROTEIN LIGASE CBL-B
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000005922|UniProtKB=H2R0P7	Protocadherin 9	ISS	8120095	PubMed	PTHR43912:SF5	PROTOCADHERIN-9
P00057	Wnt signaling pathway	P01457	GBeta	RAT|RGD=69319|UniProtKB=P54313	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IDA	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	RAT|RGD=628852|UniProtKB=Q02294	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	15079861	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	MONDO|Ensembl=ENSMODG00000018459|UniProtKB=F7CU42	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00020	FAS signaling pathway	P00604	Pro-Caspase8	MACMU|Ensembl=ENSMMUG00000012310|UniProtKB=F7DL95	CASP8 and FADD-like apoptosis regulator isoform 1	ISS			PTHR10454:SF8	CASP8 AND FADD-LIKE APOPTOSIS REGULATOR
P00047	PDGF signaling pathway	P01154	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DANRE|ZFIN=ZDB-GENE-040426-1178|UniProtKB=Q7SY24	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	MOUSE|MGI=MGI=88296|UniProtKB=O55017	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	14624853	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00047	PDGF signaling pathway	P01143	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00640	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IGI	1171954	gi	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P05731	GABA-B receptor II signaling	P05760	AC	PANTR|Ensembl=ENSPTRG00000006216|UniProtKB=H2Q832	Adenylate cyclase 4	ISS	2491850	PubMed	PTHR11920:SF286	ADENYLATE CYCLASE TYPE 4
P00029	Huntington disease	P00790	beta-Tubulin	BOVIN|Ensembl=ENSBTAG00000025274|UniProtKB=Q3MHM5	Tubulin beta-4B chain	ISS	12932731	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	THEMA|EnsemblGenome=TM_0166|UniProtKB=Q9WY13	Folylpolyglutamate synthase/dihydrofolate synthase	ISS			PTHR11136:SF0	DIHYDROFOLATE SYNTHETASE-RELATED
P00015	Circadian clock system	G01499	per	CANLF|Ensembl=ENSCAFG00000016984|UniProtKB=E2R0I6	Uncharacterized protein	ISS	20570170	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00962	ELK	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	IC	10487205	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IDA	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00011	Blood coagulation	P00406	Fibrinogen	MOUSE|MGI=MGI=99501|UniProtKB=Q8K0E8	Fibrinogen beta chain	ISS	1706801	gi	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	EMENI|EnsemblGenome=CADANIAG00002685|UniProtKB=Q5BHB3	Ribonucleotide reductase [Source:UniProtKB/TrEMBLAcc:Q9HEW8]	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	IDA	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00005	Angiogenesis	P00187	beta catenin	XENTR|Xenbase=XB-GENE-487200|UniProtKB=Q28GC2	Catenin (Cadherin associated protein), beta 1, 88kDa	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05918	p38 MAPK pathway	P06029	p38beta	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DANRE|ZFIN=ZDB-GENE-040718-93|UniProtKB=Q6DGZ5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04396	Vitamin D metabolism and pathway	P04604	FdxR	MOUSE|MGI=MGI=104724|UniProtKB=Q61578	NADPH:adrenodoxin oxidoreductase, mitochondrial	TAS	2845396	PubMed	PTHR11938:SF91	NADPH:ADRENODOXIN OXIDOREDUCTASE, MITOCHONDRIAL
P00021	FGF signaling pathway	P00632	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	MACMU|Ensembl=ENSMMUG00000013800|UniProtKB=F6T734	Uncharacterized protein	ISS			PTHR43347:SF3	ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL
P04393	Ras Pathway	P04558	p38	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	IDA	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00056	VEGF signaling pathway	P01414	PLC-gamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00021	FGF signaling pathway	P00634	MEKK1-5	HUMAN|HGNC=6854|UniProtKB=Q9Y2U5	Mitogen-activated protein kinase kinase kinase 2	IGI	8621389	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P02788	Xanthine and guanine salvage pathway	P03249	Guanine deaminase	PANTR|Ensembl=ENSPTRG00000021020|UniProtKB=H2R3N5	Uncharacterized protein	ISS	7533042	gi	PTHR11271:SF6	GUANINE DEAMINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000019361|UniProtKB=H2QUV3	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	HUMAN|HGNC=4581|UniProtKB=Q13003	Glutamate receptor ionotropic, kainate 3	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00785	Cytochrome c	NEUCR|EnsemblGenome=EFNCRG00000009557|UniProtKB=P07142	Cytochrome c1, heme protein, mitochondrial	IDA	15163634	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01465	Ggamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00053	T cell activation	P01306	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04393	Ras Pathway	P04542	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00644	p38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00049	Parkinson disease	P01227	20S proteasome	ORYSJ|Gene=Os02g0182500|UniProtKB=Q6H800	Proteasome subunit beta type	TAS	12859888	PubMed	PTHR11599:SF62	PROTEASOME SUBUNIT BETA TYPE-3
P00046	Oxidative stress response	P01135	p38	CAEEL|WormBase=WBGene00004055|UniProtKB=Q17446	Mitogen-activated protein kinase pmk-1	TAS	10851062	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02772	Pyruvate metabolism	P03137	Citrate Lyase	MOUSE|MGI=MGI=1916884|UniProtKB=Q8R4N0	Citrate lyase subunit beta-like protein, mitochondrial	ISS			PTHR11105:SF0	CITRATE LYASE SUBUNIT BETA-LIKE PROTEIN, MITOCHONDRIAL
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00562	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IGI	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00005	Angiogenesis	P00254	GTPase	HUMAN|HGNC=669|UniProtKB=P08134	Rho-related GTP-binding protein RhoC	ISS	14871999	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00001	Adrenaline and noradrenaline biosynthesis	P00068	amine translocator	PANTR|Ensembl=ENSPTRG00000005269|UniProtKB=H2Q6J9	Transporter	ISS	12719981	PubMed	PTHR11616:SF101	SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER B 0 AT2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	MOUSE|MGI=MGI=98260|UniProtKB=P10855	C-C motif chemokine 3	IDA	11704636	PubMed	PTHR12015:SF91	C-C MOTIF CHEMOKINE 3-RELATED
P00057	Wnt signaling pathway	P01431	LRP5/6	CANLF|Ensembl=ENSCAFG00000010871|UniProtKB=F1PXA0	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00049	Parkinson disease	P01227	20S proteasome	YEAST|SGD=S000003367|UniProtKB=P23638	Proteasome subunit alpha type-3	TAS	12859888	PubMed	PTHR11599:SF13	PROTEASOME SUBUNIT ALPHA TYPE-4
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	XENTR|Xenbase=XB-GENE-977853|UniProtKB=F7EBE7	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00036	Interleukin signaling pathway	P00996	STAT	BOVIN|Gene=STAT5A|UniProtKB=Q95115	Signal transducer and activator of transcription 5A	IC	95236292	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P02726	Aminobutyrate degradation	P02824	Succinate semi-aldehyde dehydrogenase	STRCO|Gene=CAC01486|UniProtKB=Q9FCA9	Putative aldehyde dehydrogenase	ISS			PTHR43217:SF1	SUCCINATE SEMIALDEHYDE DEHYDROGENASE  NAD P +  SAD
P02738	De novo purine biosynthesis	P02901	Adenosuccinate lyase	ARATH|TAIR=AT4G18440|UniProtKB=Q8RY94	Adenylosuccinate lyase	ISS			PTHR43411:SF1	ADENYLOSUCCINATE LYASE
P00002	Alpha adrenergic receptor signaling pathway	P00078	Alpha1A/1B/1C	HUMAN|HGNC=281|UniProtKB=P08913	Alpha-2A adrenergic receptor	RCA			PTHR24248:SF24	ALPHA-2A ADRENERGIC RECEPTOR
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT4G01370|UniProtKB=Q39024	Mitogen-activated protein kinase 4	ISS	10527417	PubMed	PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	ISS	8787761	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00010	B cell activation	P00398	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00059	p53 pathway	P04632	SIRT-1	MOUSE|MGI=MGI=2135607|UniProtKB=Q923E4	NAD-dependent protein deacetylase sirtuin-1	ISS			PTHR11085:SF15	NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1
P00029	Huntington disease	P00807	Actin	PHYPA|Gene=PHYPADRAFT_107830|UniProtKB=A9TBG2	Actin 7	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01164	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	15210700	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00047	PDGF signaling pathway	P01153	GSK3	ORYSJ|EnsemblGenome=OS01G0252100|UniProtKB=Q9LIS6	Os01g0252100 protein	ISS	21361340	gi	PTHR24057:SF13	SHAGGY-RELATED PROTEIN KINASE ALPHA-RELATED
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00796	Kainate receptor	MOUSE|MGI=MGI=95818|UniProtKB=Q61626	Glutamate receptor ionotropic, kainate 5	IDA	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00006	Apoptosis signaling pathway	P00269	MAPK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00046	Oxidative stress response	P01134	cPLA2	RAT|RGD=67366|UniProtKB=P50393	Cytosolic phospholipase A2	TAS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01465	Ggamma	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00021	FGF signaling pathway	P00632	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00910	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P02738	De novo purine biosynthesis	P02907	dADP kinase	CHICK|Ensembl=ENSGALG00000002932|UniProtKB=O57535	Nucleoside diphosphate kinase	ISS			PTHR11349:SF57	NUCLEOSIDE DIPHOSPHATE KINASE B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	RAT|RGD=3566|UniProtKB=P49797	Regulator of G-protein signaling 3	IDA	8756726	PubMed	PTHR10845:SF4	REGULATOR OF G-PROTEIN SIGNALING 3
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00011	Blood coagulation	P00454	FVII	PANTR|Gene=F7|UniProtKB=Q2F9P2	Coagulation factor VII	ISS	10518503	gi	PTHR44064:SF1	COAGULATION FACTOR VII
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	BRAFL|Gene=BRAFLDRAFT_220697|UniProtKB=C3ZSF0	Putative uncharacterized protein	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00053	T cell activation	P01331	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00059	p53 pathway	P04630	PP2A	CANLF|Ensembl=ENSCAFG00000006453|UniProtKB=F6X958	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Gene=CHRM2|UniProtKB=Q9N2A7	Muscarinic acetylcholine receptor M2 (Fragment)	ISS	91373358	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P04393	Ras Pathway	P04567	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	HUMAN|HGNC=4404|UniProtKB=P59768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IDA	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00056	VEGF signaling pathway	P01414	PLC-gamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00057	Wnt signaling pathway	P01457	GBeta	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00059	p53 pathway	P01481	ATM/ATR	PANTR|Ensembl=ENSPTRG00000015483|UniProtKB=H2R801	Uncharacterized protein	ISS	10196661	PubMed	PTHR11139:SF69	SERINE/THREONINE-PROTEIN KINASE ATR
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	RAT|RGD=2736|UniProtKB=P35439	Glutamate receptor ionotropic, NMDA 1	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00029	Huntington disease	P00790	beta-Tubulin	CAEEL|WormBase=WBGene00006536|UniProtKB=O17921	TuBulin, Beta	TAS	12932731	PubMed	PTHR11588:SF157	TUBULIN, BETA
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	BOVIN|Ensembl=ENSBTAG00000010402|UniProtKB=F1MQ37	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF317	MYOSIN-9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DROME|FlyBase=FBgn0000044|UniProtKB=P53501	Actin-57B	IC	11889126	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	BACSU|EnsemblGenome=BSU40420|UniProtKB=P29726	Adenylosuccinate synthetase	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	RAT|RGD=1586637|UniProtKB=F1LMY4	Ryanodine receptor 1	ISS	15858232	PubMed	PTHR13715:SF15	RYANODINE RECEPTOR 1
P04393	Ras Pathway	P04547	Ras	DANRE|ZFIN=ZDB-GENE-990415-166|UniProtKB=P79737	GTPase NRas	IDA	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	ISS	14744463	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00057	Wnt signaling pathway	P01428	Frizzled	MONDO|Ensembl=ENSMODG00000016310|UniProtKB=F7A659	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF31	FRIZZLED-7
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00029	Huntington disease	P00802	PACSIN-1	HUMAN|HGNC=8570|UniProtKB=Q9BY11	Protein kinase C and casein kinase substrate in neurons protein 1	ISS	12354780	PubMed	PTHR23065:SF16	PROTEIN KINASE C AND CASEIN KINASE SUBSTRATE IN NEURONS PROTEIN 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	MACMU|Ensembl=ENSMMUG00000010678|UniProtKB=F7AXI7	Uncharacterized protein	ISS	6717565	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00036	Interleukin signaling pathway	P00977	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	BOVIN|Ensembl=ENSBTAG00000020887|UniProtKB=F1MP22	Uncharacterized protein	ISS	14624853	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05914	Nicotine degradation	P05982	UGT1A4	HUMAN|HGNC=12535|UniProtKB=P35503	UDP-glucuronosyltransferase 1-3	TAS	12433823	PubMed	PTHR11926:SF173	UDP-GLUCURONOSYLTRANSFERASE 1-3-RELATED
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00006	Apoptosis signaling pathway	P00321	HSP70	MOUSE|MGI=MGI=96231|UniProtKB=P16627	Heat shock 70 kDa protein 1-like	ISS	12150907	PubMed	PTHR19375:SF210	HEAT SHOCK 70 KDA PROTEIN 1-LIKE
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P06002	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	STRPU|EnsemblGenome=SPU_018419|UniProtKB=W4YRI6	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P05917	Opioid proopiomelanocortin pathway	P06006	beta-Endorphin	XENTR|Xenbase=XB-GENE-483703|UniProtKB=Q5M8F2	Proopiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	RAT|RGD=1309504|UniProtKB=D3ZRN3	Protein Actbl2	ISS	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	RCA			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	ARATH|TAIR=AT4G34340|UniProtKB=Q9SYZ9	Transcription initiation factor TFIID subunit 8	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05923	beta-ARR2	RAT|RGD=2157|UniProtKB=P29067	Beta-arrestin-2	RCA	9388255	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00005	Angiogenesis	P00220	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	3136397	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P02755	Methylmalonyl pathway	P03033	Propionyl-CoA carboxylase	HALSA|EnsemblGenome=VNG_1529G|UniProtKB=Q9HPQ0	Methylmalonyl-CoA decarboxylase, subunit alpha	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	MONDO|Ensembl=ENSMODG00000014746|UniProtKB=F6YN64	Uncharacterized protein (Fragment)	ISS	12941441	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8685|UniProtKB=Q9Y5E9	Protocadherin beta-14	IDA	8120095	PubMed	PTHR24028:SF81	PROTOCADHERIN BETA-14
P00005	Angiogenesis	P00249	PAK	CANLF|Ensembl=ENSCAFG00000013067|UniProtKB=E2RJA0	Uncharacterized protein	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00057	Wnt signaling pathway	P01457	GBeta	ANOGA|EnsemblGenome=AGAP005913|UniProtKB=Q7Q6D2	AGAP005913-PA	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00019	Endothelin signaling pathway	P00589	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	IDA	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00019	Endothelin signaling pathway	P00590	IP3 R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00005	Angiogenesis	P00203	Erk	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04558	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IDA	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05731	GABA-B receptor II signaling	P05753	Ca channel	HUMAN|HGNC=1388|UniProtKB=O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	14507926	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	TAS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00558	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04378	Beta2 adrenergic receptor signaling pathway	P04440	Beta2	MACMU|Ensembl=ENSMMUG00000002214|UniProtKB=Q28509	Beta-2 adrenergic receptor	ISS	12063255	PubMed	PTHR24248:SF21	BETA-2 ADRENERGIC RECEPTOR
P00018	EGF receptor signaling pathway	P00543	ERK1-2	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P02746	Heme biosynthesis	P02972	Ferrochelatase	CHLRE|EnsemblGenome=CHLREDRAFT_183446|UniProtKB=Q9ATG8	Ferrochelatase	ISS			PTHR11108:SF1	FERROCHELATASE, MITOCHONDRIAL
P00049	Parkinson disease	P01208	Hsp70	LEIMA|EnsemblGenome=LmjF.28.1200|UniProtKB=Q4Q8E6	Putative glucose-regulated protein 78	ISS	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00049	Parkinson disease	P01215	Syntaxin	RAT|RGD=620977|UniProtKB=G3V7P1	Syntaxin-12	ISS	10321247	PubMed	PTHR19957:SF88	SYNTAXIN-12
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00773	Duo	CHICK|Ensembl=ENSGALG00000011744|UniProtKB=F1NPK0	Uncharacterized protein	ISS	9285789	PubMed	PTHR22826:SF49	KALIRIN
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	DICPU|Gene=DICPUDRAFT_46519|UniProtKB=F0Z796	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00048	PI3 kinase pathway	P01181	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00012	Cadherin signaling pathway	P00464	Fyn	CANLF|Ensembl=ENSCAFG00000003995|UniProtKB=E2RC09	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00005	Angiogenesis	P00180	Dok-R	HUMAN|HGNC=2990|UniProtKB=Q99704	Docking protein 1	IDA			PTHR21258:SF46	DOCKING PROTEIN 1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00223	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00034	Integrin signalling pathway	P00951	Jnk	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04397	p53 pathway by glucose deprivation	P04641	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00388	PLC gamma2	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ORNAN|Ensembl=ENSOANG00000007716|UniProtKB=F6UDX9	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00021	FGF signaling pathway	P00629	PP2A	PANTR|Ensembl=ENSPTRG00000006734|UniProtKB=H2Q8X8	Uncharacterized protein	ISS	8576224	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONBE|Gene=37852|UniProtKB=A9V489	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00049	Parkinson disease	P01208	Hsp70	ARATH|TAIR=AT5G28540|UniProtKB=Q9LKR3	Mediator of RNA polymerase II transcription subunit 37a	IDA	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00019	Endothelin signaling pathway	P00591	PLCbeta	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IGI	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00048	PI3 kinase pathway	P01192	p110	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	ANOGA|EnsemblGenome=AGAP000329|UniProtKB=Q7QF72	AGAP000329-PA	ISS	85270494	PubMed	PTHR18945:SF758	NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA3, ISOFORM B
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	176910	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MONDO|Ensembl=ENSMODG00000015792|UniProtKB=Q2QL96	Protein Wnt-2	ISS	8717036	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P05731	GABA-B receptor II signaling	P05755	Gbeta	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	RCA	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	RAT|RGD=1311928|UniProtKB=D3ZT83	Protein Slc1a7	ISS	96032356	PubMed	PTHR11958:SF22	EXCITATORY AMINO ACID TRANSPORTER 5
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	IDA	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	BOVIN|Ensembl=ENSBTAG00000001192|UniProtKB=A7MAZ2	STX12 protein	ISS	14570579	PubMed	PTHR19957:SF88	SYNTAXIN-12
P00034	Integrin signalling pathway	P00941	Integrin alpha	RAT|RGD=1596428|UniProtKB=D3ZAC0	Protein Itga2b	ISS	281055	gi	PTHR23220:SF73	INTEGRIN ALPHA-IIB
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	YARLI|EnsemblGenome=YALI0_D08272g|UniProtKB=Q9UVF3	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00056	VEGF signaling pathway	P01411	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00056	VEGF signaling pathway	P01425	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	2837282	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00018	EGF receptor signaling pathway	P00545	JNK1-3	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS			PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	YEAST|SGD=S000000669|UniProtKB=P25390	Serine/threonine-protein kinase SSK22	ISS			PTHR24361:SF36	SERINE/THREONINE-PROTEIN KINASE NEK4
P00025	Hedgehog signaling pathway	P00692	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00054	Toll receptor signaling pathway	P01358	ERK1	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00011	Blood coagulation	P00418	Fibrin monomer	BOVIN|Gene=FGB|UniProtKB=P02676	Fibrinogen beta chain	ISS			PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00036	Interleukin signaling pathway	P00970	Interleukin	MOUSE|MGI=MGI=96542|UniProtKB=P01582	Interleukin-1 alpha	IDA	6209582	PubMed	PTHR45409:SF1	INTERLEUKIN-1 ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01242	Casein kinase I	DANRE|ZFIN=ZDB-GENE-020419-19|UniProtKB=Q8JHE0	Casein kinase 1-alphaLS	IDA	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	BOVIN|Ensembl=ENSBTAG00000004775|UniProtKB=F1MBY1	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	IDA	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CAEBR|Gene=CBG07428|UniProtKB=A8X4S6	Protein CBR-ACR-12	ISS			PTHR18945:SF495	ACETYLCHOLINE RECEPTOR
P00019	Endothelin signaling pathway	P00572	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00034	Integrin signalling pathway	P00936	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IPI	12660731	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00021	FGF signaling pathway	P00633	Ras	YEAST|SGD=S000005042|UniProtKB=P01120	Ras-like protein 2	ISS	7997267	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00005	Angiogenesis	P00219	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00021	FGF signaling pathway	P00628	JNK1-3	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	MOUSE|MGI=MGI=99460|UniProtKB=Q61982	Neurogenic locus notch homolog protein 3	IDA	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P06211	BMP/activin signaling pathway-drosophila	P06251	BMP/activin orthologous ligand	DROME|FlyBase=FBgn0005590|UniProtKB=P54631	Protein screw	RCA	http://flybase.org/reports/FBgn0005590.html	Website	PTHR11848:SF54	PROTEIN 60A-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	DANRE|ZFIN=ZDB-GENE-010705-1|UniProtKB=Q90Z40	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00060	Ubiquitin proteasome pathway	P01490	E3	BOVIN|Ensembl=ENSBTAG00000002487|UniProtKB=A4IFN7	UBE3A protein	ISS			PTHR11254:SF301	UBIQUITIN-PROTEIN LIGASE E3A
P00049	Parkinson disease	P01208	Hsp70	MACMU|Ensembl=ENSMMUG00000005217|UniProtKB=F7C3R1	78 kDa glucose-regulated protein	ISS	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MOUSE|MGI=MGI=894644|UniProtKB=Q8CC27	Voltage-dependent L-type calcium channel subunit beta-2	IDA	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00049	Parkinson disease	P01215	Syntaxin	ORNAN|Ensembl=ENSOANG00000010187|UniProtKB=F7E0A0	Uncharacterized protein	ISS	10321247	PubMed	PTHR19957:SF90	SYNTAXIN-7
P05731	GABA-B receptor II signaling	P05753	Ca channel	BOVIN|Ensembl=ENSBTAG00000014828|UniProtKB=F1N1E0	Uncharacterized protein	ISS	8386525	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	RAT|RGD=2708|UniProtKB=P10860	Glutamate dehydrogenase 1, mitochondrial	ISS			PTHR11606:SF13	GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL
P00057	Wnt signaling pathway	P01465	Ggamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01154	Ras	TAKRU|Ensembl=ENSTRUG00000000223|UniProtKB=H2RK20	Uncharacterized protein	ISS			PTHR24073:SF335	RAS-RELATED PROTEIN RAB-11B
P00048	PI3 kinase pathway	P01185	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00011	Blood coagulation	P00437	Kallikrein	RAT|RGD=67382|UniProtKB=P14272	Plasma kallikrein	ISS	6680584	gi	PTHR44459:SF2	PLASMA KALLIKREIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00029	Huntington disease	G01535	PIG3	MACMU|Ensembl=ENSMMUG00000016001|UniProtKB=Q3I1S1	Uncharacterized protein (Fragment)	ISS	12932731	PubMed	PTHR44054:SF1	SYNAPTIC VESICLE MEMBRANE PROTEIN VAT-1 HOMOLOG
P00021	FGF signaling pathway	P00627	ERK1-2	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	NAS	6466184	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00030	Hypoxia response via HIF activation	P00824	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01409	cPLA2	MACMU|Ensembl=ENSMMUG00000021423|UniProtKB=F7EEZ1	Phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04393	Ras Pathway	P04563	Ets	MONDO|Ensembl=ENSMODG00000004730|UniProtKB=F6Y1Z2	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00053	T cell activation	P01307	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00001	Adrenaline and noradrenaline biosynthesis	P00067	MAO	MOUSE|MGI=MGI=96915|UniProtKB=Q64133	Amine oxidase [flavin-containing] A	ISS	90344230	PubMed	PTHR43563:SF3	AMINE OXIDASE  FLAVIN-CONTAINING  A
P00029	Huntington disease	P00805	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	DICDI|dictyBase=DDB_G0277869|UniProtKB=P34144	Rho-related protein rac1A	ISS			PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	RAT|RGD=621407|UniProtKB=Q62762	Casein kinase I isoform gamma-2	IDA	10617630	PubMed	PTHR11909:SF157	CASEIN KINASE I ISOFORM GAMMA-2
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	HUMAN|HGNC=5294|UniProtKB=P41595	5-hydroxytryptamine receptor 2B	ISS	12441358	PubMed	PTHR24247:SF31	5-HYDROXYTRYPTAMINE RECEPTOR 2B
P00034	Integrin signalling pathway	P00930	Dock180	MACMU|Ensembl=ENSMMUG00000018547|UniProtKB=F6YN59	Uncharacterized protein	RCA			PTHR23317:SF79	DEDICATOR OF CYTOKINESIS PROTEIN 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_56687|UniProtKB=C3YC50	Putative uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P02770	Pyridoxal phosphate salvage pathway	P03122	Pyridoxamine kinase	SCHPO|PomBase=SPAC6F6.11c|UniProtKB=O14242	Putative pyridoxal kinase C6F6.11c	ISS	11859360	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P00057	Wnt signaling pathway	P01444	Wnt	PANTR|Ensembl=ENSPTRG00000012931|UniProtKB=H2QJF8	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00015	Circadian clock system	G01501	cry	CANLF|Ensembl=ENSCAFG00000009379|UniProtKB=F1PNC9	Uncharacterized protein	ISS	10428031	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	RAT|RGD=3187|UniProtKB=Q07008	Neurogenic locus notch homolog protein 1	IDA	1764995	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	RAT|RGD=2917|UniProtKB=P15127	Insulin receptor	ISS	11182407	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	RCA	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00047	PDGF signaling pathway	P01175	Shc	MOUSE|MGI=MGI=98296|UniProtKB=P98083	SHC-transforming protein 1	ISS	95096035	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00034	Integrin signalling pathway	P00951	Jnk	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	RAT|RGD=735207|UniProtKB=P80202	Activin receptor type-1B	TAS	10683140	PubMed	PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05913	Enkephalin release	P05977	G-Protein (s)	MOUSE|MGI=MGI=1336171|UniProtKB=Q9DAS9	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00006	Apoptosis signaling pathway	P00322	Cytochrome C	MACMU|Ensembl=ENSMMUG00000032513|UniProtKB=G1K372	Uncharacterized protein	ISS	4954366	PubMed	PTHR11961:SF15	CYTOCHROME C
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00053	T cell activation	P01305	Calmodulin	ORYSJ|EnsemblGenome=OS05G0491100|UniProtKB=Q6F332	Calmodulin-2	ISS	9753452	PubMed	PTHR23050:SF324	CALMODULIN-2-RELATED
P00018	EGF receptor signaling pathway	P00558	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	RAT|RGD=621516|UniProtKB=G3V6P8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P05915	Opioid proenkephalin pathway	P05994	G-protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05915	Opioid proenkephalin pathway	P05990	K+ channel	MACMU|Ensembl=ENSMMUG00000005826|UniProtKB=F6VE51	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9063|UniProtKB=Q15111	Inactive phospholipase C-like protein 1	TAS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P00034	Integrin signalling pathway	P00907	ERK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS			PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00193	SOS-1	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00055	Transcription regulation by bZIP transcription factor	P01390	TFIIA complex	NEUCR|EnsemblGenome=EFNCRG00000002012|UniProtKB=Q7SG05	Uncharacterized protein	ISS	600519	OMIM	PTHR12694:SF8	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00005	Angiogenesis	P00203	Erk	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00059	p53 pathway	P01486	Akt	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	TAS	12719720	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01444	Wnt	CANLF|Ensembl=ENSCAFG00000031321|UniProtKB=J9NZJ2	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	XENTR|Xenbase=XB-GENE-976753|UniProtKB=Q0VFR6	Syntaxin 1A (Brain)	ISS	1321498	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P05915	Opioid proenkephalin pathway	P05995	proenkephalin	PANTR|Ensembl=ENSPTRG00000020270|UniProtKB=H2QW70	Proenkephalin	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	CANAL|EnsemblGenome=CaO19.1760|UniProtKB=Q59XU5	Ras-like protein 1	ISS	10515923	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00046	Oxidative stress response	P01129	JNK1/2	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02748	Isoleucine biosynthesis	P02997	Acetolactate synthase	CAEBR|Gene=CBG03380|UniProtKB=A8WUX0	Protein CBG03380	ISS			PTHR18968:SF155	ACETOLACTATE SYNTHASE-LIKE PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MACMU|Ensembl=ENSMMUG00000018877|UniProtKB=F6WYU6	Regulator of G-protein signaling 19	ISS	8756726	PubMed	PTHR10845:SF145	REGULATOR OF G-PROTEIN SIGNALING 19
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	10218114	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	RAT|RGD=2738|UniProtKB=Q00960	Glutamate receptor ionotropic, NMDA 2B	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04386	Histamine H2 receptor mediated signaling pathway	P04489	H2	MOUSE|MGI=MGI=108482|UniProtKB=P97292	Histamine H2 receptor	ISS	8817552	PubMed	PTHR43893:SF5	HISTAMINE H2 RECEPTOR
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00044	Nicotinic acetylcholine receptor signaling pathway	P01093	AChE	PANTR|Ensembl=ENSPTRG00000015593|UniProtKB=H2QNP1	Carboxylic ester hydrolase	ISS	86008285	PubMed	PTHR43918:SF5	CHOLINESTERASE
P00006	Apoptosis signaling pathway	P00302	ATF	CHICK|Ensembl=ENSGALG00000008494|UniProtKB=Q7SX83	CAMP response element-binding protein	ISS	11752053	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00005	Angiogenesis	P00181	SHP2	DANRE|ZFIN=ZDB-GENE-030131-5911|UniProtKB=F1QZU5	Tyrosine-protein phosphatase non-receptor type	ISS	1382983	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00013	Cell cycle	P00480	Proteasome	BOVIN|Ensembl=ENSBTAG00000021691|UniProtKB=Q17QP9	Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14	ISS	9727008	PubMed	PTHR10410:SF5	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000009594|UniProtKB=G2HFH4	Somatostatin receptor type 2	ISS	12181435	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04376	5HT4 type receptor mediated signaling pathway	P04426	K+ channel	MACMU|Ensembl=ENSMMUG00000005826|UniProtKB=F6VE51	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P05916	Opioid prodynorphin pathway	P06001	AC	BOVIN|Ensembl=ENSBTAG00000019210|UniProtKB=F1MJV4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00163	Erb-B4 C-terminal fragment	PANTR|Ensembl=ENSPTRG00000012883|UniProtKB=H2QJC5	Receptor protein-tyrosine kinase	ISS	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00168	E-cadherin intracellular fragment	HUMAN|HGNC=1748|UniProtKB=P12830	Cadherin-1	IDA	8120095	PubMed	PTHR24027:SF319	CADHERIN-1
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	XENTR|Xenbase=XB-GENE-491356|UniProtKB=Q28J24	Transcription initiation factor TFIID subunit 8	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00628	JNK1-3	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00019	Endothelin signaling pathway	P00577	PI3K	CHICK|Gene_ORFName=RCJMB04_28f9|UniProtKB=Q5ZIB8	Phosphoinositide 3-kinase regulatory subunit 5	ISS			PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=107752|UniProtKB=P46735	Unconventional myosin-Ib	IC			PTHR13140:SF277	UNCONVENTIONAL MYOSIN-IB
P00006	Apoptosis signaling pathway	P00274	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02747	Histidine biosynthesis	P02993	Phosphoribosylformimino-5-amino-1-phosphoribosyl-4 imadazol carboxamide isomerase	SCHPO|PomBase=SPAC3F10.09|UniProtKB=Q10184	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase	ISS			PTHR43090:SF2	1- 5-PHOSPHORIBOSYL -5-  5-PHOSPHORIBOSYLAMINO METHYLIDENEAMINO  IMIDAZOLE-4-CARBOXAMIDE ISOMERASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P02736	Coenzyme A biosynthesis	P02883	Pantothenoylcysteine decarboxylase	RHOBA|EnsemblGenome=RB7087|UniProtKB=Q7UP94	DNA/pantothenate metabolism flavoprotein	ISS			PTHR14359:SF6	PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	18021322	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P05731	GABA-B receptor II signaling	P05760	AC	CHICK|Gene=ADCY9|UniProtKB=Q9DGG6	Adenylate cyclase type 9	RCA	2491850	PubMed	PTHR11920:SF319	ADENYLATE CYCLASE TYPE 9
P00034	Integrin signalling pathway	P00924	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	IPI	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00019	Endothelin signaling pathway	P00576	Pre-pro ET1-4	MOUSE|MGI=MGI=95283|UniProtKB=P22387	Endothelin-1	ISS	15117818	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	IDA	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00049	Parkinson disease	P01238	14-3-3	DANRE|ZFIN=ZDB-GENE-061023-2|UniProtKB=E7F354	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00018	EGF receptor signaling pathway	P00562	p38	DROME|FlyBase=FBgn0024846|UniProtKB=O61443	Mitogen-activated protein kinase 14B	ISS	10851062	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	RAT|RGD=2734|UniProtKB=Q01812	Glutamate receptor ionotropic, kainate 4	ISS	1648176	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MACMU|Ensembl=ENSMMUG00000001304|UniProtKB=F7BNR8	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF61	TGF-BETA RECEPTOR TYPE-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	HUMAN|HGNC=4588|UniProtKB=O15399	Glutamate receptor ionotropic, NMDA 2D	IC	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=2652894|UniProtKB=Q80Y86	Mitogen-activated protein kinase 15	ISS	10851062	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	TAKRU|Ensembl=ENSTRUG00000010022|UniProtKB=H2TKL1	Actin-related protein 2/3 complex subunit 4	ISS	5031595	gi	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00048	PI3 kinase pathway	P01188	Gbetagamma	ANOGA|EnsemblGenome=AGAP005913|UniProtKB=Q7Q6D2	AGAP005913-PA	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P02771	Pyrimidine Metabolism	P03124	Methylmalonate Semialdehyde Dehydrogenase	BOVIN|Gene=ALDH6A1|UniProtKB=Q07536	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	ISS	2708830	gi	PTHR43866:SF3	METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE  ACYLATING , MITOCHONDRIAL
P00005	Angiogenesis	P00222	VEGFR-2	CHICK|Ensembl=ENSGALG00000013907|UniProtKB=F1NW21	Uncharacterized protein	ISS			PTHR24416:SF45	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2
P00021	FGF signaling pathway	P00641	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	RAT|RGD=1310096|UniProtKB=B2RZ72	Actin-related protein 2/3 complex subunit 4	ISS	9230079	PubMed	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00012	Cadherin signaling pathway	P00467	alpha-catenin	CANLF|Ensembl=ENSCAFG00000001315|UniProtKB=E2R9S7	Uncharacterized protein	ISS	1904011	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00010	B cell activation	P00402	Jnk	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CHICK|Ensembl=ENSGALG00000014539|UniProtKB=F1N861	Uncharacterized protein	ISS	1321498	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00859	NFkappaB	BOVIN|Ensembl=ENSBTAG00000013895|UniProtKB=A1XG22	NF-kappaB transcription factor p65 subunit	RCA			PTHR24169:SF1	TRANSCRIPTION FACTOR P65
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	HUMAN|HGNC=7883|UniProtKB=Q9UM47	Neurogenic locus notch homolog protein 3	IDA	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	IDA	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BRAFL|Gene=BRAFLDRAFT_104698|UniProtKB=C3XYW6	Protein Wnt (Fragment)	TAS	8717036	PubMed	PTHR12027:SF81	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00037	Ionotropic glutamate receptor pathway	P01026	KA	CANLF|Ensembl=ENSCAFG00000004930|UniProtKB=E2RFB5	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00049	Parkinson disease	P01227	20S proteasome	DICDI|dictyBase=DDB_G0267408|UniProtKB=Q27563	Proteasome subunit alpha type-3	TAS	12859888	PubMed	PTHR11599:SF10	PROTEASOME SUBUNIT ALPHA TYPE-3
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MACMU|Ensembl=ENSMMUG00000032572|UniProtKB=F7D7Y7	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P04393	Ras Pathway	P04547	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00019	Endothelin signaling pathway	P00588	ET1-4	CANLF|Ensembl=ENSCAFG00000009794|UniProtKB=P13206	Endothelin-1	ISS			PTHR13874:SF10	ENDOTHELIN-1
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04557	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MACMU|Ensembl=ENSMMUG00000009054|UniProtKB=F7F735	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00013	Cell cycle	P00489	CdkC	MACMU|Ensembl=ENSMMUG00000020668|UniProtKB=F7BEI4	Uncharacterized protein	RCA			PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	HUMAN|HGNC=4593|UniProtKB=Q13255	Metabotropic glutamate receptor 1	IDA	14614461	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00524	LIMK	CANLF|Ensembl=ENSCAFG00000012073|UniProtKB=E2RQT0	Uncharacterized protein	ISS			PTHR44124:SF1	LIM DOMAIN KINASE 1
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=2685045|UniProtKB=E9QAN8	Protein Pik3c2b	IPI	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00047	PDGF signaling pathway	P01150	PKC	SCHPO|PomBase=SPBC12D12.04c|UniProtKB=P36583	Protein kinase C-like 2	ISS	8491190	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00021	FGF signaling pathway	P00642	MEK1-2	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MACMU|Ensembl=ENSMMUG00000010904|UniProtKB=F7GLY5	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P02740	De novo pyrimidine ribonucleotides biosythesis	P02926	Aspartate carbamoyltransferase	FUSNN|EnsemblGenome=FN0419|UniProtKB=Q8RG89	Aspartate carbamoyltransferase	ISS			PTHR11405:SF16	ASPARTATE CARBAMOYLTRANSFERASE, CHLOROPLASTIC
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	HUMAN|HGNC=1401|UniProtKB=Q02641	Voltage-dependent L-type calcium channel subunit beta-1	ISS	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	CANLF|Ensembl=ENSCAFG00000012180|UniProtKB=F1PIB1	Uncharacterized protein	ISS	10409711	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	ARATH|TAIR=AT2G15430|UniProtKB=Q39211	DNA-directed RNA polymerases II, IV and V subunit 3	ISS	2187864	PubMed	PTHR11800:SF2	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3
P00010	B cell activation	P00381	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P02738	De novo purine biosynthesis	P02900	AICAR transformylase	MOUSE|MGI=MGI=1351352|UniProtKB=Q9CWJ9	Bifunctional purine biosynthesis protein PURH	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P00004	Alzheimer disease-presenilin pathway	P00118	E-cadherin	PANTR|Ensembl=ENSPTRG00000008270|UniProtKB=H2QBE5	Uncharacterized protein	ISS	11953314	PubMed	PTHR24027:SF319	CADHERIN-1
P02772	Pyruvate metabolism	P03137	Citrate Lyase	CANLF|Ensembl=ENSCAFG00000015818|UniProtKB=F1Q3V2	ATP-citrate synthase	ISS			PTHR23118:SF0	ATP-CITRATE SYNTHASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00021	FGF signaling pathway	P00629	PP2A	MONDO|Ensembl=ENSMODG00000014177|UniProtKB=F6U7A6	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	DICDI|dictyBase=DDB_G0292736|UniProtKB=Q02158	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS			PTHR10336:SF105	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE
P02736	Coenzyme A biosynthesis	P02882	Pantothenate cysteine ligase	BACTN|EnsemblGenome=BT_1362|UniProtKB=Q8A812	Flavoprotein	ISS			PTHR14359:SF6	PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	CRYNJ|EnsemblGenome=CND03830|UniProtKB=Q5KI86	Uncharacterized protein	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00029	Huntington disease	P00790	beta-Tubulin	MACMU|Ensembl=ENSMMUG00000011029|UniProtKB=F7DCY3	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	MACMU|Ensembl=ENSMMUG00000006202|UniProtKB=F7HNP4	Excitatory amino acid transporter 1 isoform 1	ISS	94365697	PubMed	PTHR11958:SF24	EXCITATORY AMINO ACID TRANSPORTER 1
P00010	B cell activation	P00379	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00056	VEGF signaling pathway	P01411	Ras	DICDI|dictyBase=DDB_G0292996|UniProtKB=P03967	Ras-like protein rasD	ISS	85024887	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	HUMAN|HGNC=7883|UniProtKB=Q9UM47	Neurogenic locus notch homolog protein 3	IDA	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00575	furin	CANLF|Ensembl=ENSCAFG00000012353|UniProtKB=E2RSE6	Uncharacterized protein	ISS	10956649	PubMed	PTHR42884:SF1	FURIN
P00049	Parkinson disease	P01238	14-3-3	TAKRU|Ensembl=ENSTRUG00000004697|UniProtKB=H2SFG7	Uncharacterized protein	ISS	22165492	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00021	FGF signaling pathway	P00629	PP2A	ARATH|TAIR=AT1G25490|UniProtKB=Q38845	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform	ISS			PTHR10648:SF4	PROTEIN PHOSPHATASE 2  FORMERLY 2A , REGULATORY SUBUNIT A, BETA ISOFORM
P00047	PDGF signaling pathway	P01175	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	10982827	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CIOIN|Ensembl=ENSCING00000000848|UniProtKB=F6SCP4	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04661	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00009	Axon guidance mediated by netrin	P00358	Ablim	DROME|FlyBase=FBgn0051352|UniProtKB=E1JIH3	Unc-115a, isoform B	ISS			PTHR24213:SF9	UNC-115A, ISOFORM B
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	IDA	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	ORNAN|Ensembl=ENSOANG00000004551|UniProtKB=F7EC93	Uncharacterized protein	ISS	11055438	PubMed	PTHR10117:SF9	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 7
P00053	T cell activation	P01311	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01154	Ras	DAPPU|EnsemblGenome=DAPPUDRAFT_301818|UniProtKB=E9I1I7	Putative uncharacterized protein	ISS	10684567	PubMed	PTHR24070:SF385	GTPASE HRAS
P00059	p53 pathway	G04694	p110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00181	SHP2	MONDO|Ensembl=ENSMODG00000003120|UniProtKB=F6WVD2	Tyrosine-protein phosphatase non-receptor type	ISS	8096088	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00047	PDGF signaling pathway	P01155	Jak	CHICK|Ensembl=ENSGALG00000011031|UniProtKB=F1NMJ9	Tyrosine-protein kinase	ISS	11929133	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02922	Orotate phosphoribosyltransferase	LEIMA|EnsemblGenome=LmjF.16.0550|UniProtKB=Q4QEW5	Putative OMPDCase-OPRTase	ISS			PTHR19278:SF9	URIDINE 5'-MONOPHOSPHATE SYNTHASE
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS			PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DANRE|ZFIN=ZDB-GENE-050417-59|UniProtKB=Q15KE4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00025	Hedgehog signaling pathway	P00692	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00010	B cell activation	P00385	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04393	Ras Pathway	P04555	PDK	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	9094314	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00036	Interleukin signaling pathway	P00965	ERK	CANLF|Ensembl=ENSCAFG00000015640|UniProtKB=E2QVF3	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00037	Ionotropic glutamate receptor pathway	P01001	KA4	MOUSE|MGI=MGI=95817|UniProtKB=Q8BMF5	Glutamate receptor ionotropic, kainate 4	ISS	1648176	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04665	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04566	Stat 1/3	MOUSE|MGI=MGI=103038|UniProtKB=P42227	Signal transducer and activator of transcription 3	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00016	Cytoskeletal regulation by Rho GTPase	P00521	Profilin	BRAFL|Gene=BRAFLDRAFT_278128|UniProtKB=C3YHE9	Profilin	ISS			PTHR11604:SF0	PROFILIN
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	PANTR|Ensembl=ENSPTRG00000001477|UniProtKB=H2Q0A5	Tyrosine-protein kinase receptor	ISS	11182407	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00057	Wnt signaling pathway	P01435	SWI/SNF	MOUSE|MGI=MGI=99603|UniProtKB=Q6DIC0	Probable global transcription activator SNF2L2	ISS	11532957	PubMed	PTHR10799:SF541	GLOBAL TRANSCRIPTION ACTIVATOR SNF2L2-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CHICK|Ensembl=ENSGALG00000001462|UniProtKB=F1NSB8	Adenosine receptor A3	IDA	11781138	PubMed	PTHR24246:SF2	ADENOSINE RECEPTOR A3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00006	Apoptosis signaling pathway	P00269	MAPK	ORYSJ|EnsemblGenome=OS02G0148100|UniProtKB=Q6Z437	Mitogen-activated protein kinase 3	ISS	10514528	PubMed	PTHR24055:SF216	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ANOGA|EnsemblGenome=AGAP000651|UniProtKB=P84185	Actin-5C	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00047	PDGF signaling pathway	P01161	Raf	MOUSE|MGI=MGI=88190|UniProtKB=P28028	Serine/threonine-protein kinase B-raf	ISS	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00037	Ionotropic glutamate receptor pathway	P01018	Glu1	DROME|FlyBase=FBgn0264000|UniProtKB=M9PHV5	Glutamate receptor IB, isoform B	ISS	12941441	PubMed	PTHR18966:SF270	GLUTAMATE RECEPTOR 1-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00206	Wnt	CAEEL|WormBase=WBGene00000858|UniProtKB=P34889	Protein Wnt-2	ISS	11266476	PubMed	PTHR12027:SF77	PROTEIN WNT-5
P00047	PDGF signaling pathway	P01143	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	TAS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	RCA	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	ORNAN|Ensembl=ENSOANG00000014753|UniProtKB=F7EPN2	Uncharacterized protein (Fragment)	ISS	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	PANTR|Ensembl=ENSPTRG00000012547|UniProtKB=H2QIU3	Uncharacterized protein	ISS	12374786	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	DROME|FlyBase=FBgn0264000|UniProtKB=M9PHV5	Glutamate receptor IB, isoform B	IC	8804111	PubMed	PTHR18966:SF270	GLUTAMATE RECEPTOR 1-RELATED
P00057	Wnt signaling pathway	P01465	Ggamma	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	8687401	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00005	Angiogenesis	P00238	Ras	MONDO|Gene=KRAS|UniProtKB=Q07983	GTPase KRas	ISS	9869449	PubMed	PTHR24070:SF186	GTPASE KRAS
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	CAEBR|Gene=CBG13013|UniProtKB=A8XGW3	Protein CBR-CDC-42	ISS			PTHR24072:SF192	CDC42 HOMOLOG
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00029	Huntington disease	P00807	Actin	CAEEL|WormBase=WBGene00000199|UniProtKB=Q9N4I0	Actin-related protein 3	IDA	11889126	PubMed	PTHR11937:SF31	ACTIN-RELATED PROTEIN 3
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00951	Jnk	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IDA	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IDA	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02738	De novo purine biosynthesis	P02907	dADP kinase	MOUSE|MGI=MGI=97355|UniProtKB=P15532	Nucleoside diphosphate kinase A	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P04398	p53 pathway feedback loops 2	P04657	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=101948|UniProtKB=P48615	Protein Wnt-11	TAS	11266476	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00010	B cell activation	P00398	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IGI	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IGI	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P02787	Vitamin B6 metabolism	P03242	Threonine synthase	DEIRA|EnsemblGenome=DR_A0360|UniProtKB=Q9RYF8	Threonine synthase	ISS	10567266	PubMed	PTHR42690:SF1	THREONINE SYNTHASE-LIKE 2
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	RAT|RGD=2343|UniProtKB=P08483	Muscarinic acetylcholine receptor M3	ISS	8100450	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00014	Cholesterol biosynthesis	P00493	Geranyl trans-transferase	MOUSE|MGI=MGI=104888|UniProtKB=Q920E5	Farnesyl pyrophosphate synthase	ISS	Q92235	SPACC	PTHR11525:SF0	FARNESYL PYROPHOSPHATE SYNTHASE
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	IC	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	6264430	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00059	p53 pathway	P04633	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IDA	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00018	EGF receptor signaling pathway	P00562	p38	CAEBR|Gene=CBG01555|UniProtKB=A8WRD7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00029	Huntington disease	P00807	Actin	BOVIN|Ensembl=ENSBTAG00000005714|UniProtKB=Q3ZC07	Actin, alpha cardiac muscle 1	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00899	IRS 1-4	HUMAN|HGNC=6128|UniProtKB=O14654	Insulin receptor substrate 4	ISS	5031805	gi	PTHR10614:SF2	INSULIN RECEPTOR SUBSTRATE 4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	SCLS1|Gene=SS1G_08733|UniProtKB=A7ETS6	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P06664	Gonadotropin-releasing hormone receptor pathway	G06670	Zeb1	MOUSE|MGI=MGI=1344313|UniProtKB=Q64318	Zinc finger E-box-binding homeobox 1	RCA			PTHR24391:SF17	ZINC FINGER E-BOX-BINDING HOMEOBOX 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04397	p53 pathway by glucose deprivation	P04644	TSC2	MACMU|Ensembl=ENSMMUG00000002808|UniProtKB=F7H034	Uncharacterized protein	ISS	12150915	PubMed	PTHR10063:SF0	TUBERIN
P00018	EGF receptor signaling pathway	P00564	Rac	MONDO|Ensembl=ENSMODG00000003244|UniProtKB=F6THF0	Uncharacterized protein	ISS	97402517	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00018	EGF receptor signaling pathway	P00552	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IGI	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P06959	CCKR signaling map	P07151	p52 SHC1	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	RCA	8760305	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00053	T cell activation	P01307	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00034	Integrin signalling pathway	P00906	Rap1	RAT|RGD=1359694|UniProtKB=P62836	Ras-related protein Rap-1A	ISS	10476970	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00034	Integrin signalling pathway	P00912	Arp2/3	MONDO|Ensembl=ENSMODG00000007194|UniProtKB=F6X9N6	Actin-related protein 2/3 complex subunit 5	ISS	12473693	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MACMU|Ensembl=ENSMMUG00000010392|UniProtKB=F7ASR8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	RAT|RGD=619965|UniProtKB=P26769	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02747	Histidine biosynthesis	P02993	Phosphoribosylformimino-5-amino-1-phosphoribosyl-4 imadazol carboxamide isomerase	YEAST|SGD=S000001282|UniProtKB=P40545	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase	ISS			PTHR43090:SF2	1- 5-PHOSPHORIBOSYL -5-  5-PHOSPHORIBOSYLAMINO METHYLIDENEAMINO  IMIDAZOLE-4-CARBOXAMIDE ISOMERASE
P00021	FGF signaling pathway	P00648	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ARATH|TAIR=AT4G28470|UniProtKB=Q6XJG8	26S proteasome non-ATPase regulatory subunit 2 homolog B	ISS			PTHR10943:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	CHICK|Gene=ALDH1A1|UniProtKB=P27463	Retinal dehydrogenase 1	IC			PTHR11699:SF140	RETINAL DEHYDROGENASE 1
P00006	Apoptosis signaling pathway	P00302	ATF	MOUSE|MGI=MGI=1926157|UniProtKB=F6VAN0	Cyclic AMP-dependent transcription factor ATF-6 alpha	ISS	11390664	PubMed	PTHR22952:SF116	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-6 ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	7492337	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00059	p53 pathway	P04612	HDAC1	ORNAN|Ensembl=ENSOANG00000003631|UniProtKB=F7FJQ1	Histone deacetylase	ISS	12665570	PubMed	PTHR10625:SF171	HISTONE DEACETYLASE 2
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	HUMAN|HGNC=4581|UniProtKB=Q13003	Glutamate receptor ionotropic, kainate 3	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	DROME|FlyBase=FBgn0011300|UniProtKB=A1Z7L8	Receptor protein serine/threonine kinase	TAS	http://www.reactome.org/	Website	PTHR23255:SF71	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00053	T cell activation	P01317	CD3 gamma	HUMAN|HGNC=1675|UniProtKB=P09693	T-cell surface glycoprotein CD3 gamma chain	IGI	9886373	PubMed	PTHR10570:SF8	T-CELL SURFACE GLYCOPROTEIN CD3 GAMMA CHAIN
P00015	Circadian clock system	P00505	Cry	CANLF|Ensembl=ENSCAFG00000001797|UniProtKB=E2RMX4	Uncharacterized protein	ISS	14507900	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00881	ROCK	MOUSE|MGI=MGI=107927|UniProtKB=P70335	Rho-associated protein kinase 1	IDA	10779382	PubMed	PTHR22988:SF33	RHO-ASSOCIATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01179	PKB	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00023	General transcription regulation	P00659	TFIIEbeta	BOVIN|Gene=GTF2E2|UniProtKB=Q2KJF9	General transcription factor IIE subunit 2	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00046	Oxidative stress response	P01129	JNK1/2	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05915	Opioid proenkephalin pathway	P05994	G-protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00053	T cell activation	P01294	NFAT	HUMAN|HGNC=7775|UniProtKB=O95644	Nuclear factor of activated T-cells, cytoplasmic 1	IGI	9462517	PubMed	PTHR12533:SF5	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00047	PDGF signaling pathway	P01175	Shc	CAEEL|WormBase=WBGene00018788|UniProtKB=Q9TYT3	SHC-transforming protein homolog 1	ISS	600560	OMIM	PTHR10337:SF11	DSHC PROTEIN
P02746	Heme biosynthesis	P02979	porphobilinogen synthase	RAT|RGD=2083|UniProtKB=P06214	Delta-aminolevulinic acid dehydratase	ISS			PTHR11458:SF0	DELTA-AMINOLEVULINIC ACID DEHYDRATASE
P00049	Parkinson disease	P01232	CASK	MOUSE|MGI=MGI=1309489|UniProtKB=O70589	Peripheral plasma membrane protein CASK	IPI	11430913	PubMed	PTHR23122:SF40	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IDA	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00048	PI3 kinase pathway	P01188	Gbetagamma	MOUSE|MGI=MGI=101848|UniProtKB=P62881	Guanine nucleotide-binding protein subunit beta-5	IC	11313908	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00051	TCA cycle	P01268	Aconitase	MOUSE|MGI=MGI=87880|UniProtKB=Q99KI0	Aconitate hydratase, mitochondrial	RCA			PTHR43160:SF3	ACONITATE HYDRATASE, MITOCHONDRIAL
P00053	T cell activation	P01320	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	BOVIN|Gene=MAT1A|UniProtKB=Q2KJC6	S-adenosylmethionine synthase isoform type-1	ISS			PTHR11964:SF11	S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-1
P00054	Toll receptor signaling pathway	P01358	ERK1	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00049	Parkinson disease	P01215	Syntaxin	MONDO|Ensembl=ENSMODG00000017550|UniProtKB=F7E0Z1	Uncharacterized protein	ISS	14570579	PubMed	PTHR19957:SF90	SYNTAXIN-7
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	IC	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Ensembl=ENSGALG00000015358|UniProtKB=F1NM49	Uncharacterized protein	IEP	89264452	PubMed	PTHR13140:SF575	MYOSIN-15
P00029	Huntington disease	P00810	GAPDH	SCHPO|PomBase=SPBC354.12|UniProtKB=O43026	Glyceraldehyde-3-phosphate dehydrogenase 2	IPI			PTHR10836:SF52	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CANLF|Ensembl=ENSCAFG00000002741|UniProtKB=E2QUR8	Uncharacterized protein	ISS			PTHR13140:SF706	UNCONVENTIONAL MYOSIN-VI
P00005	Angiogenesis	P00234	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	10521483	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00019	Endothelin signaling pathway	P00570	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00470	F-actin	DICDI|dictyBase=DDB_G0289487|UniProtKB=P07829	Actin-3	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00035	Interferon-gamma signaling pathway	P00953	Jak1	HUMAN|HGNC=6190|UniProtKB=P23458	Tyrosine-protein kinase JAK1	TAS	11929133	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	PANTR|Ensembl=ENSPTRG00000002979|UniProtKB=H2Q2M8	Uncharacterized protein	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00057	Wnt signaling pathway	P01446	Calcineurin	PANTR|Ensembl=ENSPTRG00000002631|UniProtKB=H2Q237	Serine/threonine-protein phosphatase	ISS	12015605	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00008	Axon guidance mediated by Slit/Robo	P00351	Cxcr4	HUMAN|HGNC=2561|UniProtKB=P61073	C-X-C chemokine receptor type 4	ISS	11591799	PubMed	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00018	EGF receptor signaling pathway	P00547	PP2A	DANRE|ZFIN=ZDB-GENE-040426-877|UniProtKB=F1Q6Z7	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01451	Galpha	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	IDA	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02776	Serine glycine biosynthesis	P03157	Phosphoserine aminotransferase	DROME|FlyBase=FBgn0014427|UniProtKB=Q9VAN0	Probable phosphoserine aminotransferase	ISS			PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	YEAST|SGD=S000001295|UniProtKB=P07278	cAMP-dependent protein kinase regulatory subunit	IC	91298951	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P06587	Nicotine pharmacodynamics pathway	P06601	FLNA	BOVIN|Ensembl=ENSBTAG00000011190|UniProtKB=F1N169	Uncharacterized protein	ISS	9722563	PubMed	PTHR43998:SF6	FILAMIN-A
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00206	Wnt	MOUSE|MGI=MGI=98962|UniProtKB=P28047	Protein Wnt-7b	ISS	11266476	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IDA	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P06587	Nicotine pharmacodynamics pathway	P06597	CDK5	MACMU|Ensembl=ENSMMUG00000020451|UniProtKB=F6VZU3	Uncharacterized protein	ISS	10604473	PubMed	PTHR24056:SF46	CYCLIN-DEPENDENT-LIKE KINASE 5
P06587	Nicotine pharmacodynamics pathway	P06602	PPP1CA	DANRE|ZFIN=ZDB-GENE-040516-3|UniProtKB=Q6NSN6	Serine/threonine-protein phosphatase	ISS	8392016	PubMed	PTHR11668:SF191	SERINE/THREONINE-PROTEIN PHOSPHATASE
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00045	Notch signaling pathway	P01120	NIcs	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P02746	Heme biosynthesis	P02982	Protoheme IX farnesyl transferase	ANOGA|Gene=AgaP_AGAP008884|UniProtKB=Q7PWQ5	AGAP008884-PA	ISS			PTHR43448:SF2	PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	MOUSE|MGI=MGI=96573|UniProtKB=P01326	Insulin-2	ISS			PTHR11454:SF29	INSULIN-2
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04393	Ras Pathway	P04547	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00010	B cell activation	P00388	PLC gamma2	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P05730	Endogenous cannabinoid signaling	P05746	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-9966|UniProtKB=Q6TH03	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	HUMAN|HGNC=712|UniProtKB=P32121	Beta-arrestin-2	IDA	9388255	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00049	Parkinson disease	P01208	Hsp70	MOUSE|MGI=MGI=99517|UniProtKB=P17879	Heat shock 70 kDa protein 1B	IDA	12150907	PubMed	PTHR19375:SF223	HEAT SHOCK 70 KDA PROTEIN 1A-RELATED
P00053	T cell activation	P01331	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04398	p53 pathway feedback loops 2	P04652	E2F-1	XENTR|Xenbase=XB-GENE-974737|UniProtKB=F6VW96	Uncharacterized protein	ISS	20337912	PubMed	PTHR12081:SF44	TRANSCRIPTION FACTOR E2F3
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00547	PP2A	STRPU|EnsemblGenome=SPU_025182|UniProtKB=W4ZAK5	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P06212	DPP-SCW signaling pathway	P06265	MED	DROME|FlyBase=FBgn0011648|UniProtKB=P42003	Protein mothers against dpp	RCA			PTHR13703:SF40	PROTEIN MOTHERS AGAINST DPP
P05916	Opioid prodynorphin pathway	P05999	provasopressin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	12885769	PubMed	PTHR10202:SF13	PRESENILIN-2
P00005	Angiogenesis	P00217	STAT3	MONDO|Ensembl=ENSMODG00000028212|UniProtKB=F7BYN4	Signal transducer and activator of transcription	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00047	PDGF signaling pathway	P01168	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	ISS	12660731	PubMed	PTHR10048:SF14	PI-3 KINASE
P00013	Cell cycle	P00480	Proteasome	HUMAN|HGNC=16889|UniProtKB=O00487	26S proteasome non-ATPase regulatory subunit 14	ISS	9727008	PubMed	PTHR10410:SF5	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 14
P00019	Endothelin signaling pathway	P00566	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00193	SOS-1	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DANRE|ZFIN=ZDB-GENE-040426-1354|UniProtKB=Q7T2C5	Protein kinase C	ISS	11880265	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00570	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00053	T cell activation	P01322	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01230	Src kinase	MOUSE|MGI=MGI=95602|UniProtKB=P39688	Tyrosine-protein kinase Fyn	IDA	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	ORNAN|Ensembl=ENSOANG00000000818|UniProtKB=F6PLI7	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00931	Integrin beta	MOUSE|MGI=MGI=96612|UniProtKB=O54890	Integrin beta-3	IDA	280842	gi	PTHR10082:SF25	INTEGRIN BETA-3
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05918	p38 MAPK pathway	P06027	CREB	MONDO|Ensembl=ENSMODG00000015970|UniProtKB=F7FD05	Uncharacterized protein	ISS	11752053	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00021	FGF signaling pathway	P00645	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12176041	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00020	FAS signaling pathway	P00601	c-Jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04376	5HT4 type receptor mediated signaling pathway	P04431	5HT transporter	RAT|RGD=3714|UniProtKB=P31652	Sodium-dependent serotonin transporter	ISS	7681602	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P00021	FGF signaling pathway	P00627	ERK1-2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	DANRE|ZFIN=ZDB-GENE-030903-5|UniProtKB=Q6EWH2	Tyrosine-protein kinase fyna	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00005	Angiogenesis	P00219	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00035	Interferon-gamma signaling pathway	P00961	STAT1	HUMAN|HGNC=11362|UniProtKB=P42224	Signal transducer and activator of transcription 1-alpha/beta	TAS	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00050	Plasminogen activating cascade	P01246	Plasmin	HUMAN|HGNC=9071|UniProtKB=P00747	Plasminogen	ISS	4505881	gi	PTHR24261:SF6	PLASMINOGEN
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P02736	Coenzyme A biosynthesis	P02886	Pantetheine-phosphate adenyltransferase	DEIRA|EnsemblGenome=DR_0642|UniProtKB=Q9RWM4	Phosphopantetheine adenylyltransferase	ISS			PTHR21342:SF1	PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE
P02742	Tetrahydrofolate biosynthesis	P02944	Phosphoribosylglycinamide formyltransferase	BACSU|EnsemblGenome=BSU06510|UniProtKB=P12040	Phosphoribosylglycinamide formyltransferase	ISS			PTHR43369:SF2	PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE
P00047	PDGF signaling pathway	P01167	Ets	DROME|FlyBase=FBgn0004510|UniProtKB=Q04688	DNA-binding protein Ets97D	ISS	15298723	PubMed	PTHR11849:SF195	GA-BINDING PROTEIN ALPHA CHAIN
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000001384|UniProtKB=F7GL73	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00005	Angiogenesis	P00238	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00756	Recoverin	PANTR|Ensembl=ENSPTRG00000008762|UniProtKB=H2QC95	Uncharacterized protein	ISS	7953452	PubMed	PTHR23055:SF20	RECOVERIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	RAT|RGD=2036|UniProtKB=P40146	Adenylate cyclase type 8	IGI	2491850	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00021	FGF signaling pathway	P00628	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00025	Hedgehog signaling pathway	P00682	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00012	Cadherin signaling pathway	P00474	Wnt	PANTR|Ensembl=ENSPTRG00000017278|UniProtKB=H2QRJ8	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P02738	De novo purine biosynthesis	P02904	Guanylate kinase	RAT|RGD=1309638|UniProtKB=E9PTV0	Guanylate kinase 1, isoform CRA_a	ISS			PTHR23117:SF13	GUANYLATE KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	PANTR|Ensembl=ENSPTRG00000002149|UniProtKB=H2R0U9	Uncharacterized protein	ISS	15858232	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P05731	GABA-B receptor II signaling	P05754	Ggamma	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	ORNAN|Ensembl=ENSOANG00000003489|UniProtKB=F7FSE3	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	DROME|Gene=Dmel_CG1891|UniProtKB=A0A0B4K7J3	Receptor protein serine/threonine kinase	TAS	8134837	PubMed	PTHR23255:SF72	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MOUSE|MGI=MGI=107335|UniProtKB=P55105	Bone morphogenetic protein 8B	TAS	9759503	PubMed	PTHR11848:SF132	BONE MORPHOGENETIC PROTEIN 8B
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00005	Angiogenesis	P00219	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	FUSNN|EnsemblGenome=FN1605|UniProtKB=P58793	Adenylosuccinate synthetase	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P06587	Nicotine pharmacodynamics pathway	P06607	EPB41	HUMAN|HGNC=3377|UniProtKB=P11171	Protein 4.1	TAS	12181426	PubMed	PTHR23280:SF12	PROTEIN 4.1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00059	p53 pathway	G04696	Siah	MACMU|Ensembl=ENSMMUG00000007400|UniProtKB=F6T3K3	E3 ubiquitin-protein ligase	ISS	14985507	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00046	Oxidative stress response	P01136	Elk-1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	TAS	9644975	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00019	Endothelin signaling pathway	P00568	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IGI	3045562	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00010	B cell activation	P00398	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IGI	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05730	Endogenous cannabinoid signaling	P05748	mGluR	RAT|RGD=2742|UniProtKB=P23385	Metabotropic glutamate receptor 1	ISS	12351712	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00048	PI3 kinase pathway	P01179	PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=4596|UniProtKB=Q14833	Metabotropic glutamate receptor 4	IDA	12488551	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00060	Ubiquitin proteasome pathway	P01491	E2	CANLF|Ensembl=ENSCAFG00000006177|UniProtKB=F1PYX5	Uncharacterized protein	ISS			PTHR43902:SF2	UBIQUITIN-CONJUGATING ENZYME E2 N
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00965	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IC	176948	OMIM	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MACMU|Ensembl=ENSMMUG00000014601|UniProtKB=B8XIA5	Myc proto-oncogene protein	ISS	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00056	VEGF signaling pathway	P01407	Erk	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02746	Heme biosynthesis	P02979	porphobilinogen synthase	AQUAE|EnsemblGenome=aq_2109|UniProtKB=O67876	Delta-aminolevulinic acid dehydratase	ISS			PTHR11458:SF0	DELTA-AMINOLEVULINIC ACID DEHYDRATASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=620023|UniProtKB=P10980	Muscarinic acetylcholine receptor M2	IDA	11166329	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	HUMAN|HGNC=17298|UniProtKB=Q9HAW0	Transcription factor IIIB 50 kDa subunit	ISS			PTHR11618:SF5	TRANSCRIPTION FACTOR IIIB 50 KDA SUBUNIT
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00053	T cell activation	P01320	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	TAKRU|Ensembl=ENSTRUG00000011297|UniProtKB=H2TV18	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00259	TNF	PANTR|Ensembl=ENSPTRG00000017965|UniProtKB=Q8HZD9	Tumor necrosis factor	ISS	11911478	PubMed	PTHR11471:SF23	TUMOR NECROSIS FACTOR
P00029	Huntington disease	P00797	p53	DANRE|ZFIN=ZDB-GENE-080724-2|UniProtKB=A5A5E1	Cytoplasmic FMR1 interacting protein 2	ISS			PTHR12195:SF1	CYTOPLASMIC FMR1-INTERACTING PROTEIN 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00006	Apoptosis signaling pathway	P00313	IKK	CANLF|Ensembl=ENSCAFG00000009588|UniProtKB=E2RNA9	Uncharacterized protein	ISS	9346484	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00238	Ras	CHICK|Ensembl=ENSGALG00000014033|UniProtKB=E1BTS2	Uncharacterized protein	ISS	99084794	PubMed	PTHR24070:SF186	GTPASE KRAS
P00034	Integrin signalling pathway	P00938	Cdc42	IXOSC|EnsemblGenome=ISCW003614|UniProtKB=B7PHY7	Cdc42 protein, putative	ISS	9658176	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04393	Ras Pathway	P04565	MKK4/7	MONDO|Ensembl=ENSMODG00000008266|UniProtKB=F6Z879	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00865	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	7798194	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04393	Ras Pathway	P04547	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	P01438	PP2A	MOUSE|MGI=MGI=1321159|UniProtKB=P63330	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00019	Endothelin signaling pathway	P00586	Gq	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	DANRE|ZFIN=ZDB-GENE-010705-1|UniProtKB=Q90Z40	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00053	T cell activation	P01333	cdc42	MACMU|Ensembl=ENSMMUG00000022009|UniProtKB=F6RBZ7	Cell division control protein 42 homolog isoform 2	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	20908895	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04393	Ras Pathway	P04558	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IDA	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	PUCGT|EnsemblGenome=PGTG_11337|UniProtKB=E3KLJ3	Calmodulin	ISS			PTHR23050:SF245	AT16150P-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04393	Ras Pathway	P04574	PLD	PANTR|Ensembl=ENSPTRG00000008610|UniProtKB=H2QBY9	Uncharacterized protein	ISS	12615079	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	RCA	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	ISS	94131269	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	BOVIN|Gene=IL2RA|UniProtKB=P12342	Interleukin-2 receptor subunit alpha	ISS	1572550	PubMed	PTHR10573:SF0	INTERLEUKIN-2 RECEPTOR SUBUNIT ALPHA
P00030	Hypoxia response via HIF activation	P00824	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	IDA	11707292	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00589	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01322	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00990	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P05916	Opioid prodynorphin pathway	P06002	G-protein	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00036	Interleukin signaling pathway	P00983	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00562	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	IPI	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Gene=ACTA2|UniProtKB=P08023	Actin, aortic smooth muscle	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00159	Nectin 1alpha intracellular fragment	HUMAN|HGNC=9706|UniProtKB=Q15223	Nectin-1	ISS	12376527	PubMed	PTHR23277:SF69	NECTIN-1
P00030	Hypoxia response via HIF activation	P00824	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	TAS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	DROME|FlyBase=FBgn0031261|UniProtKB=Q9VPQ8	Nicotinic acetylcholine receptor beta 3 (Dbeta3) subunit	IC			PTHR18945:SF597	NICOTINIC ACETYLCHOLINE RECEPTOR BETA 3  DBETA3  SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04398	p53 pathway feedback loops 2	P04665	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01421	Rac	RAT|RGD=1306068|UniProtKB=D4A6C5	Protein Arhgap1	ISS			PTHR23176:SF28	RHO GTPASE-ACTIVATING PROTEIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DANRE|ZFIN=ZDB-GENE-040426-1354|UniProtKB=Q7T2C5	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00029	Huntington disease	P00785	Cytochrome c	SCHPO|PomBase=SPBC29A3.18|UniProtKB=O59680	Cytochrome c1, heme protein, mitochondrial	IDA	9027315	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00010	B cell activation	P00373	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	ARATH|TAIR=AT5G09810|UniProtKB=P53492	Actin-7	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	RAT|RGD=3144|UniProtKB=Q63356	Unconventional myosin-Ie	IC			PTHR13140:SF341	UNCONVENTIONAL MYOSIN-IE
P00010	B cell activation	P00371	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	RCA	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ASHGO|EnsemblGenome=AGOS_ABR222W|UniProtKB=Q75D00	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MOUSE|MGI=MGI=96276|UniProtKB=Q61224	5-hydroxytryptamine receptor 1D	IDA			PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	8787761	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	XENTR|Xenbase=XB-GENE-971917|UniProtKB=A0JM97	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF42	REGULATOR OF G-PROTEIN SIGNALING 5
P00011	Blood coagulation	P00419	FXIIIa	MOUSE|MGI=MGI=1921395|UniProtKB=Q8BH61	Coagulation factor XIII A chain	ISS	11067435	gi	PTHR11590:SF42	COAGULATION FACTOR XIII A CHAIN
P05915	Opioid proenkephalin pathway	P05994	G-protein	XENTR|Xenbase=XB-GENE-956713|UniProtKB=Q5XGD8	Guanine nucleotide binding protein, beta 3	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00048	PI3 kinase pathway	P01182	Ras	NEUCR|EnsemblGenome=EFNCRG00000008769|UniProtKB=P22126	Protein ras-1	ISS	7997267	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00010	B cell activation	P00388	PLC gamma2	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04397	p53 pathway by glucose deprivation	P04642	Rheb	MOUSE|MGI=MGI=97912|UniProtKB=Q921J2	GTP-binding protein Rheb	ISS			PTHR24070:SF264	GTP-BINDING PROTEIN RHEB
P00006	Apoptosis signaling pathway	P00318	PKCs	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IDA	2837282	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00029	Huntington disease	P00778	NMDA receptor	MONDO|Ensembl=ENSMODG00000018204|UniProtKB=F6PGX6	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00048	PI3 kinase pathway	P01199	Galpha	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	IC	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00029	Huntington disease	P00811	Arp2/3 complex	MACMU|Ensembl=ENSMMUG00000001458|UniProtKB=F7BKH1	Uncharacterized protein	ISS	12932731	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	MACMU|Ensembl=ENSMMUG00000009928|UniProtKB=F6Y5E5	Uncharacterized protein	ISS	12374786	PubMed	PTHR11767:SF17	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 3
P06959	CCKR signaling map	P07220	A-Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	RCA	15520807	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00059	p53 pathway	P04609	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	7565716	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00005	Angiogenesis	P00238	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00057	Wnt signaling pathway	P01440	Cadherin	BOVIN|Ensembl=ENSBTAG00000004081|UniProtKB=F1MC84	Uncharacterized protein	ISS	8120095	PubMed	PTHR24026:SF49	PROTOCADHERIN FAT 3
P00034	Integrin signalling pathway	P00924	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IDA	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04393	Ras Pathway	P04558	p38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IDA	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00019	Endothelin signaling pathway	P00589	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	XENTR|Xenbase=XB-GENE-479036|UniProtKB=Q640R7	Ras-related protein Rap-1b	ISS	1904317	PubMed	PTHR24070:SF382	RAS-RELATED PROTEIN RAP-1B
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000019277|UniProtKB=H2QUQ1	Uncharacterized protein	ISS	1321498	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=3036262|UniProtKB=Q3USB7	Inactive phospholipase C-like protein 1	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P00019	Endothelin signaling pathway	P00585	ECE1-3	MACMU|Ensembl=ENSMMUG00000010942|UniProtKB=F7GIX6	Uncharacterized protein	ISS	8034569	PubMed	PTHR11733:SF130	ENDOTHELIN-CONVERTING ENZYME 1
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00321	HSP70	DICPU|Gene=DICPUDRAFT_49867|UniProtKB=F0ZVR4	Heat shock protein	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00021	FGF signaling pathway	P00631	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8316835	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00048	PI3 kinase pathway	P01188	Gbetagamma	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00029	Huntington disease	P00807	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g210933|UniProtKB=A7SEA7	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00059	p53 pathway	G01579	PTEN	DROME|FlyBase=FBgn0026379|UniProtKB=Q7KMQ6	IP16020p	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P02784	Tyrosine biosynthesis	P03213	Aromatic amino acid aminotransferase	ANOGA|EnsemblGenome=AGAP000327|UniProtKB=Q7QF69	AGAP000327-PA	ISS			PTHR11751:SF368	TYROSINE AMINOTRANSFERASE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	IC	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000012820|UniProtKB=F1MDL3	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00029	Huntington disease	P00780	Microtubule	PHYPA|Gene=PHYPADRAFT_121199|UniProtKB=A9RY37	Predicted protein	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	MOUSE|MGI=MGI=96575|UniProtKB=P15208	Insulin receptor	TAS	14500580	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P02769	Purine metabolism	P03118	Guanine Deaminase	PSEAE|EnsemblGenome=PA1521|UniProtKB=Q9I3J2	Probable guanine deaminase	ISS	10984043	PubMed	PTHR11271:SF6	GUANINE DEAMINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	DANRE|ZFIN=ZDB-GENE-070705-73|UniProtKB=B8A561	Uncharacterized protein	ISS			PTHR13140:SF676	MYOSIN, HEAVY POLYPEPTIDE 2, FAST MUSCLE SPECIFIC
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00036	Interleukin signaling pathway	P00977	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	PSEAE|EnsemblGenome=PA3807|UniProtKB=Q59636	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	IC	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	PHYPA|Gene=PHYPADRAFT_185037|UniProtKB=A9SHH7	Predicted protein	ISS	9753452	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00006	Apoptosis signaling pathway	P00283	A1	MOUSE|MGI=MGI=102687|UniProtKB=Q07440	Bcl-2-related protein A1	IGI	11964303	PubMed	PTHR11256:SF10	BCL-2-RELATED PROTEIN A1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00029	Huntington disease	P00796	Kainate receptor	BOVIN|Ensembl=ENSBTAG00000033153|UniProtKB=F1MG21	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g234494|UniProtKB=A7RU31	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CHICK|Ensembl=ENSGALG00000007794|UniProtKB=A9YZQ5	Dopamine receptor 2 protein transcript variant 1	ISS	11248120	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P05913	Enkephalin release	P05975	GPCR (s)	DANRE|ZFIN=ZDB-GENE-010125-1|UniProtKB=B8JHS2	Uncharacterized protein	ISS	11259498	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MONDO|Ensembl=ENSMODG00000008889|UniProtKB=F7BRY9	Serine/threonine-protein kinase receptor	ISS	9395284	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00029	Huntington disease	P00796	Kainate receptor	MACMU|Ensembl=ENSMMUG00000017431|UniProtKB=F7HPP3	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00049	Parkinson disease	P01236	Casein kinase II	YEAST|SGD=S000005565|UniProtKB=P38930	Casein kinase II subunit beta'	IDA	10806215	PubMed	PTHR11740:SF13	CASEIN KINASE II SUBUNIT BETA'
P00057	Wnt signaling pathway	P01456	beta-arrestin	RAT|RGD=2157|UniProtKB=P29067	Beta-arrestin-2	IDA	12464600	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	RAT|RGD=3644|UniProtKB=P97545	Eotaxin	ISS			PTHR12015:SF146	EOTAXIN
P00005	Angiogenesis	P00203	Erk	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00019	Endothelin signaling pathway	P00577	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IGI	96009592	PubMed	PTHR10048:SF14	PI-3 KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	RAT|RGD=2917|UniProtKB=P15127	Insulin receptor	ISS	14500580	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MOUSE|MGI=MGI=87905|UniProtKB=P68033	Actin, alpha cardiac muscle 1	IDA	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CHICK|Gene=ACTA2|UniProtKB=P08023	Actin, aortic smooth muscle	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00060	Ubiquitin proteasome pathway	P01491	E2	MOUSE|MGI=MGI=107411|UniProtKB=P52482	Ubiquitin-conjugating enzyme E2 E1	ISS			PTHR24068:SF70	UBIQUITIN-CONJUGATING ENZYME E2 E1
P00059	p53 pathway	G04702	p53	MOUSE|MGI=MGI=98834|UniProtKB=P02340	Cellular tumor antigen p53	TAS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00053	T cell activation	P01319	PAK	BOVIN|Ensembl=ENSBTAG00000015670|UniProtKB=E1B7J7	Uncharacterized protein	ISS	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00053	T cell activation	P01330	IKK	HUMAN|HGNC=5960|UniProtKB=O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	IGI	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00023	General transcription regulation	P00658	TBP-associated factors	DROME|FlyBase=FBgn0011836|UniProtKB=Q24325	Transcription initiation factor TFIID subunit 2	ISS			PTHR15137:SF9	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2
P00029	Huntington disease	P00778	NMDA receptor	CHICK|Ensembl=ENSGALG00000011809|UniProtKB=F1NMB0	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01286	TGFbeta	DANRE|ZFIN=ZDB-GENE-011214-1|UniProtKB=F1R5Z7	Serine palmitoyltransferase small subunit B	IDA	11748836	PubMed	PTHR11848:SF152	SERINE PALMITOYLTRANSFERASE SMALL SUBUNIT B
P00010	B cell activation	P00402	Jnk	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00005	Angiogenesis	P00238	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00018	EGF receptor signaling pathway	P00561	STAT	MONDO|Ensembl=ENSMODG00000014816|UniProtKB=F7CHH2	Signal transducer and activator of transcription	ISS	96102059	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00057	Wnt signaling pathway	P01444	Wnt	CAEEL|WormBase=WBGene00003395|UniProtKB=Q10459	Protein mom-2	ISS	8717036	PubMed	PTHR12027:SF3	PROTEIN MOM-2
P00019	Endothelin signaling pathway	P00566	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IGI	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00036	Interleukin signaling pathway	P00983	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00004	Alzheimer disease-presenilin pathway	P00134	Nectin 1alpha transmembrane fragment	MACMU|Ensembl=ENSMMUG00000008274|UniProtKB=F7HBK1	Uncharacterized protein	ISS	12376527	PubMed	PTHR23277:SF69	NECTIN-1
P00012	Cadherin signaling pathway	P00470	F-actin	ARATH|TAIR=AT3G46520|UniProtKB=P53497	Actin-12	IC	11889126	PubMed	PTHR11937:SF276	ACTIN-12
P00017	DNA replication	P00527	Histones	MONBE|Gene=21514|UniProtKB=A9UZD4	Histone H3	ISS	12413958	PubMed	PTHR11426:SF172	HISTONE H3-LIKE 5-RELATED
P00057	Wnt signaling pathway	P01451	Galpha	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	IDA	8836152	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00047	PDGF signaling pathway	P01163	c-Jun	ARATH|TAIR=AT1G71230|UniProtKB=Q9FVU9	COP9 signalosome complex subunit 5a	ISS			PTHR10410:SF6	COP9 SIGNALOSOME COMPLEX SUBUNIT 5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000012005|UniProtKB=F7H091	Metabotropic glutamate receptor 2 isoform a	ISS	20012997	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00047	PDGF signaling pathway	P01143	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	G04694	p110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01292	RSmads	HUMAN|HGNC=6767|UniProtKB=Q15797	Mothers against decapentaplegic homolog 1	TAS	12736218	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P00035	Interferon-gamma signaling pathway	P00952	Jak2	HUMAN|HGNC=6192|UniProtKB=O60674	Tyrosine-protein kinase JAK2	TAS	22482294	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00048	PI3 kinase pathway	P01179	PKB	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01167	Ets	BOVIN|Ensembl=ENSBTAG00000002341|UniProtKB=A5PJG9	ETS1 protein	ISS	9157999	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02756	N-acetylglucosamine metabolism	P03036	N-acetylglucosamine-6-phosphate deacetylase	ANOGA|EnsemblGenome=AGAP002347|UniProtKB=Q7QBX3	N-acetylglucosamine-6-phosphate deacetylase	ISS			PTHR11113:SF14	N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE
P04393	Ras Pathway	P04570	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01411	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	IDA	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05935	AngII	MACMU|Ensembl=ENSMMUG00000005881|UniProtKB=F6TLR3	Uncharacterized protein	ISS			PTHR11461:SF13	ANGIOTENSINOGEN
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00890	ELK	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	10487205	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	MACMU|Ensembl=ENSMMUG00000013637|UniProtKB=F7GL52	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MOUSE|MGI=MGI=96570|UniProtKB=Q04998	Inhibin beta A chain	TAS	11451570	PubMed	PTHR11848:SF133	INHIBIN BETA A CHAIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P06959	CCKR signaling map	G06973	FOS	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	RCA	10362639	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	HUMAN|HGNC=10940|UniProtKB=P43004	Excitatory amino acid transporter 2	ISS	94365697	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P00049	Parkinson disease	P01219	SAPK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04393	Ras Pathway	P04542	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00012	Cadherin signaling pathway	P00470	F-actin	ORYSJ|EnsemblGenome=OS05G0438800|UniProtKB=Q75HX0	Actin	IC	10974003	PubMed	PTHR11937:SF248	SUBFAMILY NOT NAMED
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	10395542	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00010	B cell activation	P00381	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01375	JNK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	ISS	10851062	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00011	Blood coagulation	P00458	GP IIIa	MOUSE|MGI=MGI=96612|UniProtKB=O54890	Integrin beta-3	ISS	5805339	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00750	Rhodopsin kinase	MACMU|Ensembl=ENSMMUG00000007427|UniProtKB=F6SX33	Rhodopsin kinase	ISS	8288567	PubMed	PTHR24355:SF11	RHODOPSIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02787	Vitamin B6 metabolism	P03242	Threonine synthase	ASHGO|EnsemblGenome=AGOS_AAR059C|UniProtKB=Q00063	Threonine synthase	ISS	15001715	PubMed	PTHR42690:SF1	THREONINE SYNTHASE-LIKE 2
P00048	PI3 kinase pathway	P01179	PKB	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	TAS	14526383	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01451	Galpha	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=1751|UniProtKB=P55289	Cadherin-12	IDA	8120095	PubMed	PTHR24027:SF96	CADHERIN-12
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00021	FGF signaling pathway	P00642	MEK1-2	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MONDO|Ensembl=ENSMODG00000001384|UniProtKB=F7GL73	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P05913	Enkephalin release	P05972	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00010	B cell activation	P00379	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00059	p53 pathway	P04631	P21	PANTR|Ensembl=ENSPTRG00000018107|UniProtKB=H2RFJ9	Uncharacterized protein	ISS	7774811	PubMed	PTHR10265:SF16	CYCLIN-DEPENDENT KINASE INHIBITOR 1
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	CHICK|Ensembl=ENSGALG00000012575|UniProtKB=E1C492	Uncharacterized protein	ISS	9783586	PubMed	PTHR10814:SF23	TRANSDUCIN-LIKE ENHANCER PROTEIN 1
P00057	Wnt signaling pathway	P01435	SWI/SNF	HUMAN|HGNC=1916|UniProtKB=Q86WJ1	Chromodomain-helicase-DNA-binding protein 1-like	ISS	11532957	PubMed	PTHR10799:SF949	CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1-LIKE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00020	FAS signaling pathway	P00599	Caspase3	MACMU|Ensembl=ENSMMUG00000012053|UniProtKB=F7HFY2	Uncharacterized protein	ISS	7983002	PubMed	PTHR10454:SF198	CASPASE-3
P06587	Nicotine pharmacodynamics pathway	P06606	ADCY2	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00021	FGF signaling pathway	P00627	ERK1-2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04417	5HT transporter	BOVIN|Gene=SLC6A4|UniProtKB=Q9XT49	Sodium-dependent serotonin transporter	ISS	14653308	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P00007	Axon guidance mediated by semaphorins	P00341	Rho	BOVIN|Ensembl=ENSBTAG00000004279|UniProtKB=P61585	Transforming protein RhoA	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00057	Wnt signaling pathway	P01463	Kremen	MOUSE|MGI=MGI=1920266|UniProtKB=Q8K1S7	Kremen protein 2	ISS			PTHR24269:SF15	KREMEN PROTEIN 2
P00036	Interleukin signaling pathway	P00990	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05913	Enkephalin release	P05977	G-Protein (s)	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00029	Huntington disease	P00805	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00011	Blood coagulation	P00429	PN2	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	ISS	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000021941|UniProtKB=F6UY89	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF97	PROTOCADHERIN BETA-15
P00025	Hedgehog signaling pathway	P00682	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	8787761	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	DROME|FlyBase=FBgn0011290|UniProtKB=P49905	Transcription initiation factor TFIID subunit 12	ISS			PTHR12264:SF21	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12
P00057	Wnt signaling pathway	P01435	SWI/SNF	PANTR|Ensembl=ENSPTRG00000018733|UniProtKB=H2QTY4	Uncharacterized protein	ISS	11532957	PubMed	PTHR12656:SF11	AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 1B
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CAEEL|WormBase=WBGene00001187|UniProtKB=Q8MQA1	Uncharacterized protein	IC	15621031	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00038	JAK/STAT signaling pathway	P01027	STAT	HUMAN|HGNC=11362|UniProtKB=P42224	Signal transducer and activator of transcription 1-alpha/beta	ISS	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00047	PDGF signaling pathway	P01175	Shc	MOUSE|MGI=MGI=106179|UniProtKB=Q61120	SHC-transforming protein 3	ISS	12006576	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P02747	Histidine biosynthesis	P02991	Histidinephosphate aminotransferase	ARATH|TAIR=AT5G10330|UniProtKB=B9DHD3	Histidinol-phosphate aminotransferase 1, chloroplastic	ISS			PTHR42885:SF2	HISTIDINOL-PHOSPHATE AMINOTRANSFERASE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	ORNAN|Ensembl=ENSOANG00000002061|UniProtKB=F7ANC6	Uncharacterized protein	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00019	Endothelin signaling pathway	P00587	Raf-1	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS			PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00012	Cadherin signaling pathway	P00464	Fyn	DANRE|ZFIN=ZDB-GENE-030903-5|UniProtKB=Q6EWH2	Tyrosine-protein kinase fyna	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	HUMAN|HGNC=11589|UniProtKB=P62380	TATA box-binding protein-like protein 1	ISS	600075	OMIM	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DANRE|ZFIN=ZDB-GENE-041001-104|UniProtKB=Q5TZD4	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P02748	Isoleucine biosynthesis	P02998	Dihydroxyacid dehydratase	RHOBA|EnsemblGenome=RB12087|UniProtKB=Q7UJ69	Dihydroxy-acid dehydratase	ISS			PTHR21000:SF5	DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00756	Recoverin	BOVIN|Ensembl=ENSBTAG00000025088|UniProtKB=P21457	Recoverin	ISS	9753452	PubMed	PTHR23055:SF20	RECOVERIN
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ANOGA|EnsemblGenome=AGAP005912|UniProtKB=Q7Q6D3	AGAP005912-PA	IC	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00010	B cell activation	P00369	MEKK	BOVIN|Ensembl=ENSBTAG00000004216|UniProtKB=F1MSX4	Uncharacterized protein	ISS	21735556	gi	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00509	Slingshot	HUMAN|HGNC=30579|UniProtKB=Q8WYL5	Protein phosphatase Slingshot homolog 1	ISS			PTHR10159:SF138	PROTEIN PHOSPHATASE SLINGSHOT HOMOLOG 1
P04393	Ras Pathway	P04552	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00018	EGF receptor signaling pathway	P00551	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02746	Heme biosynthesis	P02983	Hydroxymethylbilane synthase	PSEAE|EnsemblGenome=PA5260|UniProtKB=Q60169	Porphobilinogen deaminase	ISS			PTHR11557:SF0	PORPHOBILINOGEN DEAMINASE
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000021963|UniProtKB=F6S1W0	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF234	PROTOCADHERIN GAMMA-C5
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	DANRE|ZFIN=ZDB-GENE-040718-74|UniProtKB=Q90ZZ8	Aldehyde dehydrogenase	ISS			PTHR43570:SF19	ALDEHYDE DEHYDROGENASE
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	RAT|RGD=1359613|UniProtKB=Q66HA2	Cyclic AMP-responsive element-binding protein 3-like protein 1	ISS	123810	OMIM	PTHR22952:SF24	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 1
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00029	Huntington disease	P00786	ARF	YEAST|SGD=S000002351|UniProtKB=P11076	ADP-ribosylation factor 1	IPI	12932731	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00009	Axon guidance mediated by netrin	P00363	PI3K	XENTR|Xenbase=XB-GENE-6067221|UniProtKB=F6Z0J4	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00965	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IC	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00562	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	CAEBR|Gene=CBG_05938|UniProtKB=H8WGV2	Protein CBR-ITR-1, isoform a	ISS	12880387	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00561	STAT	DANRE|ZFIN=ZDB-GENE-980526-499|UniProtKB=Q6P943	Signal transducer and activator of transcription	IGI	99348060	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	MACMU|Ensembl=ENSMMUG00000016328|UniProtKB=F7GSV7	Uncharacterized protein	RCA			PTHR22952:SF100	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3
P05912	Dopamine receptor mediated signaling pathway	P05957	K+ channel	RAT|RGD=621451|UniProtKB=Q9ES08	Potassium channel subfamily K member 9	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00029	Huntington disease	P00796	Kainate receptor	MOUSE|MGI=MGI=95817|UniProtKB=Q8BMF5	Glutamate receptor ionotropic, kainate 4	ISS	11319238	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00047	PDGF signaling pathway	P01171	PLCgamma	CAEBR|Gene=CBG18715|UniProtKB=A8XTZ1	Phosphoinositide phospholipase C	ISS			PTHR10336:SF91	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00996	STAT	MOUSE|MGI=MGI=103039|UniProtKB=Q9WVL2	Signal transducer and activator of transcription 2	IC	11786546	PubMed	PTHR11801:SF41	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 2
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	MACMU|Ensembl=ENSMMUG00000001304|UniProtKB=F7BNR8	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF61	TGF-BETA RECEPTOR TYPE-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	MACMU|Ensembl=ENSMMUG00000010707|UniProtKB=F7G8G5	Signal transducer and activator of transcription	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00034	Integrin signalling pathway	P00938	Cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	PANTR|Ensembl=ENSPTRG00000023608|UniProtKB=H2QZZ2	Uncharacterized protein	ISS	11554549	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00053	T cell activation	P01305	Calmodulin	RAT|RGD=2257|UniProtKB=P62161	Calmodulin	ISS	10487978	PubMed	PTHR23050:SF311	CALMODULIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	RAT|RGD=1561298|UniProtKB=D4AE80	Protein Dcp1a	ISS	12809600	PubMed	PTHR16290:SF4	MRNA-DECAPPING ENZYME 1A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	NEUCR|EnsemblGenome=EFNCRG00000004240|UniProtKB=Q01386	cAMP-dependent protein kinase regulatory subunit	IC	97076137	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8657|UniProtKB=Q9NPG4	Protocadherin-12	IDA	8120095	PubMed	PTHR24028:SF42	PROTOCADHERIN-12
P00021	FGF signaling pathway	P00632	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	IGI	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01322	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00034	Integrin signalling pathway	P00925	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	MACMU|Ensembl=ENSMMUG00000010173|UniProtKB=F7AGU8	Presenilin	ISS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00036	Interleukin signaling pathway	P00975	RasGAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	ISS	2574500	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	BOVIN|Gene=PCSK1|UniProtKB=Q9GLR1	Neuroendocrine convertase 1	IDA			PTHR42884:SF14	NEUROENDOCRINE CONVERTASE 1
P00053	T cell activation	P01335	jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	ARATH|TAIR=AT5G26667|UniProtKB=O04905	UMP-CMP kinase 3	ISS			PTHR23359:SF107	UMP-CMP KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	RAT|RGD=735207|UniProtKB=P80202	Activin receptor type-1B	TAS	10683140	PubMed	PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P00048	PI3 kinase pathway	P01179	PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01205	NOS	PANTR|Ensembl=ENSPTRG00000019868|UniProtKB=H2QVM2	Nitric oxide synthase	ISS	10435050	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00006	Apoptosis signaling pathway	P00274	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00048	PI3 kinase pathway	P01185	SOS	CHICK|Ensembl=ENSGALG00000013224|UniProtKB=F1NMA4	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00973	PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00644	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02751	Lysine biosynthesis	P03007	Diaminopimelate decarboxylase	PSEAE|EnsemblGenome=PA5277|UniProtKB=P19572	Diaminopimelate decarboxylase	ISS			PTHR43727:SF2	DIAMINOPIMELATE DECARBOXYLASE 1, CHLOROPLASTIC-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00545	JNK1-3	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IGI	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00018	EGF receptor signaling pathway	P00559	MEK1-2	LEIMA|EnsemblGenome=LmjF.13.0440|UniProtKB=Q4QGB0	Mitogen-activated protein kinase kinase 2	ISS			PTHR22983:SF6	SERINE/THREONINE-PROTEIN KINASE 36
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00048	PI3 kinase pathway	P01202	p85	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	HUMAN|HGNC=12023|UniProtKB=P56180	Putative tyrosine-protein phosphatase TPTE	IGI			PTHR12305:SF32	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE TPTE2-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PANTR|Ensembl=ENSPTRG00000011333|UniProtKB=H2R5W8	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF462	MYOSIN-14
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	BOVIN|Gene=MYH7|UniProtKB=Q9BE39	Myosin-7	ISS	89264452	PubMed	PTHR13140:SF344	MYOSIN-7
P04395	Vasopressin synthesis	P04597	Signal Peptide	MOUSE|MGI=MGI=97453|UniProtKB=P35454	Oxytocin-neurophysin 1	ISS	1706187	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00877	MLCK	HUMAN|HGNC=29826|UniProtKB=Q32MK0	Myosin light chain kinase 3	IDA	11157482	PubMed	PTHR45411:SF1	MYOSIN LIGHT CHAIN KINASE 3
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CAEEL|WormBase=WBGene00004056|UniProtKB=Q8MXI4	Mitogen-activated protein kinase pmk-2	IDA	10851062	PubMed	PTHR24055:SF154	MITOGEN-ACTIVATED PROTEIN KINASE PMK-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DANRE|ZFIN=ZDB-GENE-040426-1354|UniProtKB=Q7T2C5	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00029	Huntington disease	P00788	Calpain	CHICK|Gene=CAPN3|UniProtKB=Q92177	Calpain-3	IDA	11675509	PubMed	PTHR10183:SF329	CALPAIN-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00025	Hedgehog signaling pathway	P00682	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05918	p38 MAPK pathway	P06026	MEKK4	CANLF|Ensembl=ENSCAFG00000000760|UniProtKB=E2R9L4	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00034	Integrin signalling pathway	P00906	Rap1	ANOGA|EnsemblGenome=AGAP001874|UniProtKB=F5HMC8	AGAP001874-PA	ISS	8576107	PubMed	PTHR24070:SF263	RAS-LIKE PROTEIN 3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P05731	GABA-B receptor II signaling	P05754	Ggamma	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02723	Adenine and hypoxanthine salvage pathway	P02808	Deoxyadenosine phosphorylase	BOVIN|Ensembl=ENSBTAG00000012317|UniProtKB=P55859	Purine nucleoside phosphorylase	ISS	9585525	PubMed	PTHR11904:SF12	PURINE NUCLEOSIDE PHOSPHORYLASE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00046	Oxidative stress response	P01126	ATF2	CANLF|Ensembl=ENSCAFG00000013332|UniProtKB=F1PCQ4	Uncharacterized protein	ISS	7875593	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	IDA	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04393	Ras Pathway	P04547	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00036	Interleukin signaling pathway	P00964	p90RSK	MACMU|Ensembl=ENSMMUG00000022111|UniProtKB=F7H7W3	Ribosomal protein S6 kinase	ISS	7688567	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00021	FGF signaling pathway	P00627	ERK1-2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06959	CCKR signaling map	P07022	CCK-22	HUMAN|HGNC=1569|UniProtKB=P06307	Cholecystokinin	RCA		PubMed	PTHR10786:SF0	CHOLECYSTOKININ
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00019	Endothelin signaling pathway	P00574	Big ET1-4	HUMAN|HGNC=3177|UniProtKB=P20800	Endothelin-2	IGI	12516960	PubMed	PTHR13874:SF9	ENDOTHELIN-2
P05918	p38 MAPK pathway	P06032	MKK6	MOUSE|MGI=MGI=1346870|UniProtKB=P70236	Dual specificity mitogen-activated protein kinase kinase 6	RCA	8622669	PubMed	PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	RAT|RGD=3238|UniProtKB=P01179	Oxytocin-neurophysin 1	ISS	9756087	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00005	Angiogenesis	P00254	GTPase	PANTR|Ensembl=ENSPTRG00000014922|UniProtKB=H2QML4	Uncharacterized protein	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	PSEAE|EnsemblGenome=PA3111|UniProtKB=Q9HZA8	Folylpolyglutamate synthetase	ISS			PTHR11136:SF0	DIHYDROFOLATE SYNTHETASE-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	TAS	8132661	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00049	Parkinson disease	P01211	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01162	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00562	p38	YEAST|SGD=S000004103|UniProtKB=P32485	Mitogen-activated protein kinase HOG1	ISS			PTHR24055:SF247	MITOGEN-ACTIVATED PROTEIN KINASE HOG1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00019	Endothelin signaling pathway	P00587	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00467	alpha-catenin	MONDO|Ensembl=ENSMODG00000015456|UniProtKB=F6S406	Uncharacterized protein	ISS	1638632	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	ORYSJ|EnsemblGenome=OS06G0154500|UniProtKB=Q84UI5	Mitogen-activated protein kinase 1	ISS			PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P00022	General transcription by RNA polymerase I	P00657	TBP	NEUCR|EnsemblGenome=EFNCRG00000004595|UniProtKB=Q7RVB4	TATA-binding protein	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00036	Interleukin signaling pathway	P00970	Interleukin	HUMAN|HGNC=5991|UniProtKB=P01583	Interleukin-1 alpha	ISS	7561102	PubMed	PTHR45409:SF1	INTERLEUKIN-1 ALPHA
P00021	FGF signaling pathway	P00648	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	RAT|RGD=619985|UniProtKB=P18298	S-adenosylmethionine synthase isoform type-2	ISS			PTHR11964:SF12	S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	XENTR|Xenbase=XB-GENE-963560|UniProtKB=Q0VFC4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00231	HSP27	PANTR|Ensembl=ENSPTRG00000034105|UniProtKB=H2R4Z0	Uncharacterized protein	ISS			PTHR11527:SF163	HEAT SHOCK PROTEIN BETA-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00035	Interferon-gamma signaling pathway	P00958	PIAS	PANTR|Ensembl=ENSPTRG00000001206|UniProtKB=H2PZU2	Uncharacterized protein	ISS	8682149	PubMed	PTHR10782:SF10	E3 SUMO-PROTEIN LIGASE PIAS3
P00021	FGF signaling pathway	P00638	PLCgamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Gene=OPRM1|UniProtKB=P79350	Mu-type opioid receptor	IDA	12093103	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P02756	N-acetylglucosamine metabolism	P03038	N-acetylmannosamine kinase	FUSNN|EnsemblGenome=FN1474|UniProtKB=Q8RDN7	N-acetylmannosamine kinase	ISS			PTHR18964:SF151	SUBFAMILY NOT NAMED
P02723	Adenine and hypoxanthine salvage pathway	P02804	Hypoxanthine phosphoribosyl transferase	ARATH|TAIR=AT1G71750|UniProtKB=F4IA25	Hypoxanthine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P04397	p53 pathway by glucose deprivation	P04641	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00392	I kappa B	HUMAN|HGNC=7797|UniProtKB=P25963	NF-kappa-B inhibitor alpha	ISS	14665694	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IDA	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04543	MEKK1/4	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS	9305639	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00034	Integrin signalling pathway	P00924	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00010	B cell activation	P00383	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P06664	Gonadotropin-releasing hormone receptor pathway	G06680	c-fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	RCA	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	ANOGA|EnsemblGenome=AGAP010958|UniProtKB=Q7PFI3	AGAP010958-PA	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00029	Huntington disease	P00796	Kainate receptor	CHICK|Ensembl=ENSGALG00000006638|UniProtKB=R4GGL9	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF31	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00633	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00023	General transcription regulation	P00670	TBP	CHICK|Ensembl=ENSGALG00000013981|UniProtKB=Q9YGV8	TATA box-binding protein-like protein 1	IPI	10454611	PubMed	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00053	T cell activation	P01300	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01143	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	EMENI|EnsemblGenome=CADANIAG00007315|UniProtKB=P20359	Actin, gamma	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05731	GABA-B receptor II signaling	P05760	AC	CANLF|Ensembl=ENSCAFG00000001097|UniProtKB=E2RCX6	Uncharacterized protein	ISS	12890691	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00057	Wnt signaling pathway	P01428	Frizzled	PANTR|Ensembl=ENSPTRG00000009279|UniProtKB=H2QD74	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF34	FRIZZLED-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MACMU|Ensembl=ENSMMUG00000012387|UniProtKB=F7EB20	Uncharacterized protein	ISS	12168099	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00053	T cell activation	P01302	CD3 eta	HUMAN|HGNC=1674|UniProtKB=P07766	T-cell surface glycoprotein CD3 epsilon chain	IGI	9886373	PubMed	PTHR10570:SF9	T-CELL SURFACE GLYCOPROTEIN CD3 EPSILON CHAIN
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	SYNY3|EnsemblGenome=BAA18695|UniProtKB=P74587	Carbamoyl-phosphate synthase small chain	ISS			PTHR11405:SF4	CARBAMOYL-PHOSPHATE SYNTHASE ARGININE-SPECIFIC SMALL CHAIN
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00034	Integrin signalling pathway	P00916	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IPI	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04393	Ras Pathway	P04557	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00047	PDGF signaling pathway	P01165	SRF	RAT|RGD=1559787|UniProtKB=D3ZHH8	Protein Srf	ISS	8660892	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00014	Cholesterol biosynthesis	P00494	Squalene monooxygenas	MOUSE|MGI=MGI=109296|UniProtKB=P52019	Squalene monooxygenase	ISS			PTHR10835:SF0	SQUALENE MONOOXYGENASE
P05913	Enkephalin release	P05974	G-Protein (i)	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	IC	15860573	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MACMU|Ensembl=ENSMMUG00000022114|UniProtKB=F7H7V5	Uncharacterized protein	ISS	12549854	PubMed	PTHR11309:SF81	FRIZZLED-1
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02748	Isoleucine biosynthesis	P02997	Acetolactate synthase	DEIRA|EnsemblGenome=DR_1516|UniProtKB=Q9RU76	Acetolactate synthase	ISS			PTHR18968:SF116	ACETOLACTATE SYNTHASE ISOZYME 3 LARGE SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00029	Huntington disease	P00776	c-Jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00635	FRS2	RAT|RGD=1308201|UniProtKB=A0A0G2JZZ5	Protein Frs2	ISS	10464310	PubMed	PTHR21258:SF40	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00005	Angiogenesis	P00221	JNK1	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00012	Cadherin signaling pathway	P00462	Casein kinase II	CIOIN|Ensembl=ENSCING00000003902|UniProtKB=Q967X2	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00010	B cell activation	P00398	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	DROME|FlyBase=FBgn0011300|UniProtKB=A1Z7L8	Receptor protein serine/threonine kinase	TAS	http://www.reactome.org/	Website	PTHR23255:SF71	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00045	Notch signaling pathway	G01541	E(spl)-C genes	BOVIN|Ensembl=ENSBTAG00000000569|UniProtKB=Q3ZBG4	Transcription factor HES-1	ISS	14973298	PubMed	PTHR10985:SF19	TRANSCRIPTION FACTOR HES-1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00021	FGF signaling pathway	P00648	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IGI	2837282	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00048	PI3 kinase pathway	P01179	PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00057	Wnt signaling pathway	P01465	Ggamma	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00008	Axon guidance mediated by Slit/Robo	P00351	Cxcr4	MOUSE|MGI=MGI=109563|UniProtKB=P70658	C-X-C chemokine receptor type 4	ISS	11943720	PubMed	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00019	Endothelin signaling pathway	P00568	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	11591316	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00223	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	DANRE|ZFIN=ZDB-GENE-040718-93|UniProtKB=Q6DGZ5	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00056	VEGF signaling pathway	P01417	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04397	p53 pathway by glucose deprivation	P04641	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00475	Frizzled	BOVIN|Ensembl=ENSBTAG00000040128|UniProtKB=F1MLJ8	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF23	FRIZZLED-4
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00049	Parkinson disease	P01208	Hsp70	ORYSJ|EnsemblGenome=OS01G0840100|UniProtKB=Q943K7	70 kDa heat shock protein	IDA	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	CANLF|Gene=SLC1A6|UniProtKB=Q9N1R2	Excitatory amino acid transporter 4	ISS	94365697	PubMed	PTHR11958:SF67	EXCITATORY AMINO ACID TRANSPORTER 4
P00010	B cell activation	P00384	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	MONDO|Ensembl=ENSMODG00000001775|UniProtKB=F6WJB1	Uncharacterized protein	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P04393	Ras Pathway	P04556	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	IDA	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00645	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12874273	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00047	PDGF signaling pathway	P01174	Rho	MONDO|Ensembl=ENSMODG00000003016|UniProtKB=F6Q2Q1	Uncharacterized protein	ISS	8288572	PubMed	PTHR23181:SF5	RHO GTPASE-ACTIVATING PROTEIN 15
P00004	Alzheimer disease-presenilin pathway	P00114	actin	TAKRU|Ensembl=ENSTRUG00000005494|UniProtKB=P53483	Actin, alpha anomalous	IDA	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00021	FGF signaling pathway	P00648	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04393	Ras Pathway	P04552	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00629	PP2A	PANTR|Ensembl=ENSPTRG00000006426|UniProtKB=H2Q8F8	Protein phosphatase 2, regulatory subunit B', epsilon isoform	ISS	11007767	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	NEUCR|EnsemblGenome=EFNCRG00000004240|UniProtKB=Q01386	cAMP-dependent protein kinase regulatory subunit	ISS	176892	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	IGI	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00016	Cytoskeletal regulation by Rho GTPase	P00521	Profilin	HUMAN|HGNC=8882|UniProtKB=P35080	Profilin-2	ISS			PTHR13936:SF15	PROFILIN-2
P00021	FGF signaling pathway	P00643	Raf-1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IGI	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00013	Cell cycle	P00480	Proteasome	PANTR|Ensembl=ENSPTRG00000012575|UniProtKB=H2QIW0	Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14	ISS	9727008	PubMed	PTHR10410:SF5	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 14
P00048	PI3 kinase pathway	P01182	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P04393	Ras Pathway	P04542	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	IGI	8557110	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ORNAN|Ensembl=ENSOANG00000007716|UniProtKB=F6UDX9	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00037	Ionotropic glutamate receptor pathway	P01026	KA	ORNAN|Ensembl=ENSOANG00000010302|UniProtKB=F6TDQ6	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00029	Huntington disease	P00780	Microtubule	ARATH|TAIR=AT4G20890|UniProtKB=P29517	Tubulin beta-9 chain	IDA	9454836	PubMed	PTHR11588:SF245	TUBULIN BETA-4 CHAIN-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	CAEEL|WormBase=WBGene00001680|UniProtKB=Q20636	Guanine nucleotide-binding protein subunit beta-2	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	IDA	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MOUSE|MGI=MGI=106066|UniProtKB=Q62035	Platelet-activating factor receptor	TAS	12038971	PubMed	PTHR24233:SF6	PLATELET-ACTIVATING FACTOR RECEPTOR
P00057	Wnt signaling pathway	P01438	PP2A	PANTR|Ensembl=ENSPTRG00000001958|UniProtKB=H2Q137	Uncharacterized protein	ISS	12110603	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00375	Calmodulin	MOUSE|MGI=MGI=103249|UniProtKB=P62204	Calmodulin	ISS	3885394	PubMed	PTHR23050:SF311	CALMODULIN
P00001	Adrenaline and noradrenaline biosynthesis	P00061	PNMT	BOVIN|Gene=PNMT|UniProtKB=P10938	Phenylethanolamine N-methyltransferase	ISS	12438093	PubMed	PTHR10867:SF18	PHENYLETHANOLAMINE N-METHYLTRANSFERASE
P00006	Apoptosis signaling pathway	P00268	GCK	MACMU|Ensembl=ENSMMUG00000020550|UniProtKB=F7D279	Mitogen-activated protein kinase kinase kinase kinase	ISS			PTHR24361:SF324	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 5
P00047	PDGF signaling pathway	P01143	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05730	Endogenous cannabinoid signaling	P05748	mGluR	HUMAN|HGNC=4597|UniProtKB=P41594	Metabotropic glutamate receptor 5	ISS	9407094	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P06959	CCKR signaling map	P07090	MAPK8-10	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	RCA	12239223	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00047	PDGF signaling pathway	P01143	ERK	ORYSJ|Gene=Os01g0665200|UniProtKB=Q5SN53	Mitogen-activated protein kinase 8	ISS	10514528	PubMed	PTHR24055:SF219	SUBFAMILY NOT NAMED
P06959	CCKR signaling map	P07059	BCL2	HUMAN|HGNC=990|UniProtKB=P10415	Apoptosis regulator Bcl-2	RCA	18719002	PubMed	PTHR11256:SF11	APOPTOSIS REGULATOR BCL-2
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	XENTR|Xenbase=XB-GENE-963560|UniProtKB=Q0VFC4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	PANTR|Ensembl=ENSPTRG00000013189|UniProtKB=H2QJV1	Uncharacterized protein	ISS	6717565	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00048	PI3 kinase pathway	P01181	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00011	Blood coagulation	P00407	PZ	HUMAN|HGNC=9460|UniProtKB=P22891	Vitamin K-dependent protein Z	ISS			PTHR24278:SF20	VITAMIN K-DEPENDENT PROTEIN Z
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MONDO|Ensembl=ENSMODG00000024440|UniProtKB=F7DJJ2	Muscarinic acetylcholine receptor	ISS	11166329	PubMed	PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00005	Angiogenesis	P00243	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00540	MKK3,6	MACMU|Ensembl=ENSMMUG00000010904|UniProtKB=F7GLY5	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00010	B cell activation	P00370	NFkappaB	BOVIN|Ensembl=ENSBTAG00000006017|UniProtKB=F6Q9X9	Uncharacterized protein	ISS	12574369	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	91056091	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	IDA	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00780	Microtubule	MACMU|Ensembl=ENSMMUG00000008877|UniProtKB=F7DTM8	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IDA	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00922	Collagen	BOVIN|Gene=COL11A2|UniProtKB=Q32S24	Collagen alpha-2(XI) chain	ISS	10778855	PubMed	PTHR24023:SF509	COLLAGEN ALPHA-2 XI  CHAIN
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	PANTR|Ensembl=ENSPTRG00000015241|UniProtKB=Q5IS72	D(3) dopamine receptor	ISS	7651368	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P06959	CCKR signaling map	G07280	CCND1	HUMAN|HGNC=1582|UniProtKB=P24385	G1/S-specific cyclin-D1	RCA	15116100	PubMed	PTHR10177:SF67	G1/S-SPECIFIC CYCLIN-D1
P00018	EGF receptor signaling pathway	P00565	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	IGI	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P02775	Salvage pyrimidine ribonucleotides	P03155	Cytosine deaminase	CAEEL|WormBase=WBGene00010436|UniProtKB=Q95QD6	Uncharacterized protein	ISS			PTHR11079:SF92	TRNA-SPECIFIC ADENOSINE DEAMINASE 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	DICDI|dictyBase=DDB_G0286557|UniProtKB=Q8T9S7	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS			PTHR12305:SF79	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00019	Endothelin signaling pathway	P00589	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06802	IR	MOUSE|MGI=MGI=96575|UniProtKB=P15208	Insulin receptor	RCA	11182407	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	SCHPO|PomBase=SPAC17G8.14c|UniProtKB=P36582	Protein kinase C-like 1	IC	93259141	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00020	FAS signaling pathway	P00609	FAF1	BOVIN|Ensembl=ENSBTAG00000014482|UniProtKB=Q29RM7	Fas (TNFRSF6) associated factor 1	ISS	8524870	PubMed	PTHR23322:SF52	FAS-ASSOCIATED FACTOR 1
P05916	Opioid prodynorphin pathway	P06002	G-protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	ISS	15860573	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P06664	Gonadotropin-releasing hormone receptor pathway	P06812	L-type Ca2+	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	RCA	8838325	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04566	Stat 1/3	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	15825084	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00048	PI3 kinase pathway	P01187	IR	CANLF|Ensembl=ENSCAFG00000018170|UniProtKB=E2RPM8	Tyrosine-protein kinase receptor	ISS	2983222	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BOVIN|Gene=WNT16|UniProtKB=Q5E9U6	Protein Wnt-16	ISS	8717036	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P00047	PDGF signaling pathway	P01143	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=3233|UniProtKB=P33533	Delta-type opioid receptor	IDA	12093103	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00018	EGF receptor signaling pathway	P00555	MKK4,7	DROME|FlyBase=FBgn0024326|UniProtKB=O61444	MAP kinase kinase 4, isoform A	NAS	7600581	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02783	Tryptophan biosynthesis	P03207	Tryptophan synthase A	ARATH|TAIR=AT4G02610|UniProtKB=O22765	Tryptophan synthase alpha chain	ISS			PTHR43406:SF4	TRYPTOPHAN SYNTHASE ALPHA CHAIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	BOVIN|Ensembl=ENSBTAG00000011802|UniProtKB=E1BI98	Uncharacterized protein	ISS	10727440	PubMed	PTHR44172:SF3	COLLAGEN ALPHA-1 VI  CHAIN
P00047	PDGF signaling pathway	P01157	MAPKAPK2	MACMU|Ensembl=ENSMMUG00000023567|UniProtKB=F7HHY8	Uncharacterized protein	ISS	8262198	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00053	T cell activation	P01294	NFAT	RAT|RGD=1307690|UniProtKB=D4A0I8	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (Predicted), isoform CRA_b	ISS	12787506	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	RAT|RGD=2059|UniProtKB=P18090	Beta-1 adrenergic receptor	IDA	12063255	PubMed	PTHR24248:SF54	BETA-1 ADRENERGIC RECEPTOR
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Ensembl=ENSPTRG00000018449|UniProtKB=H2QTG5	Uncharacterized protein	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000011757|UniProtKB=Q9XT97	Presenilin-1	TAS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P05916	Opioid prodynorphin pathway	P06002	G-protein	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00585	ECE1-3	DROME|FlyBase=FBgn0039564|UniProtKB=Q9VAY0	CG5527	ISS			PTHR11733:SF160	FI17316P1-RELATED
P05913	Enkephalin release	P05972	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00557	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IGI	1171954	gi	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PHYPA|Gene=PHYPADRAFT_198730|UniProtKB=Q6TYS2	Actin 1	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	P01435	SWI/SNF	XENTR|Xenbase=XB-GENE-494817|UniProtKB=F6Y042	Uncharacterized protein	ISS	11532957	PubMed	PTHR10799:SF887	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5
P04393	Ras Pathway	P04557	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CAEEL|WormBase=WBGene00000065|UniProtKB=P0DM42	Actin-3	IC	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00018	EGF receptor signaling pathway	P00542	EGFR	MACMU|Ensembl=ENSMMUG00000001674|UniProtKB=F7G3H1	Receptor protein-tyrosine kinase	ISS	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	DROME|Gene=Dmel_CG1891|UniProtKB=A0A0B4K7J3	Receptor protein serine/threonine kinase	TAS	8134837	PubMed	PTHR23255:SF72	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MONDO|Ensembl=ENSMODG00000000771|UniProtKB=F6SSS3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P04393	Ras Pathway	P04558	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00034	Integrin signalling pathway	P00951	Jnk	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	ARATH|TAIR=AT2G30910|UniProtKB=O80856	Actin-related protein 2/3 complex subunit 1A	ISS	12963527	gi	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00012	Cadherin signaling pathway	P00474	Wnt	DANRE|ZFIN=ZDB-GENE-980526-87|UniProtKB=Q92050	Protein Wnt-5b	IDA	8717036	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P02785	Valine biosynthesis	P03217	Dihydroxy isovalerate reductoisomerase	BACSU|EnsemblGenome=BSU28290|UniProtKB=P37253	Ketol-acid reductoisomerase	ISS			PTHR21371:SF1	KETOL-ACID REDUCTOISOMERASE, CHLOROPLASTIC
P00030	Hypoxia response via HIF activation	P00814	P300	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IDA	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00159	Nectin 1alpha intracellular fragment	RAT|RGD=620791|UniProtKB=F1LNP8	Poliovirus receptor-related 1	ISS	12376527	PubMed	PTHR23277:SF69	NECTIN-1
P00034	Integrin signalling pathway	P00948	Rho	PANTR|Ensembl=ENSPTRG00000001112|UniProtKB=H2PZP2	Ras homolog gene family, member C	ISS	12090470	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IC	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00775	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05966	EPB41	MACMU|Ensembl=ENSMMUG00000007758|UniProtKB=F7BWK5	Uncharacterized protein	ISS	12181426	PubMed	PTHR23280:SF17	BAND 4.1-LIKE PROTEIN 2
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00021	FGF signaling pathway	P00628	JNK1-3	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02723	Adenine and hypoxanthine salvage pathway	P02808	Deoxyadenosine phosphorylase	BACSU|EnsemblGenome=BSU23490|UniProtKB=P46354	Purine nucleoside phosphorylase 1	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00029	Huntington disease	P00780	Microtubule	BRAFL|Gene=BRAFLDRAFT_60807|UniProtKB=C3Y2F5	Putative uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	MOUSE|MGI=MGI=104636|UniProtKB=Q62440	Transducin-like enhancer protein 1	IDA	9783586	PubMed	PTHR10814:SF23	TRANSDUCIN-LIKE ENHANCER PROTEIN 1
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MOUSE|MGI=MGI=1339713|UniProtKB=Q5SX39	Myosin-4	ISS	89264452	PubMed	PTHR13140:SF657	MYOSIN-4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_188187|UniProtKB=E9GJ31	Guanine nucleotide binding protein, q polypeptide	ISS	14765990	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00018	EGF receptor signaling pathway	P00562	p38	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	IGI	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00568	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00048	PI3 kinase pathway	P01185	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00006	Apoptosis signaling pathway	P00288	TNFR1	MACMU|Ensembl=ENSMMUG00000000377|UniProtKB=F6YFE9	Uncharacterized protein	ISS	11861282	PubMed	PTHR23097:SF177	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1A
P00005	Angiogenesis	P00182	p38MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05728	Anandamide degradation	P05741	FAAH	MACMU|Ensembl=ENSMMUG00000002714|UniProtKB=F7HMW4	Uncharacterized protein	ISS	12060782	PubMed	PTHR11895:SF91	FATTY-ACID AMIDE HYDROLASE 1
P00036	Interleukin signaling pathway	P00996	STAT	HUMAN|HGNC=11365|UniProtKB=Q14765	Signal transducer and activator of transcription 4	IC	12496413	PubMed	PTHR11801:SF19	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 4
P00047	PDGF signaling pathway	P01142	p90RSK	RAT|RGD=1305144|UniProtKB=D4AE24	Ribosomal protein S6 kinase	ISS	15116068	PubMed	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00018	EGF receptor signaling pathway	P00540	MKK3,6	RAT|RGD=620666|UniProtKB=Q925D6	Mitogen-activated protein kinase kinase 6	ISS	8622669	PubMed	PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P00018	EGF receptor signaling pathway	P00550	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	4504111	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04395	Vasopressin synthesis	P04592	Exopeptidase	HUMAN|HGNC=2303|UniProtKB=P16870	Carboxypeptidase E	ISS	1778303	PubMed	PTHR11532:SF59	CARBOXYPEPTIDASE E
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CANLF|Ensembl=ENSCAFG00000019823|UniProtKB=E2R4I7	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P00053	T cell activation	P01304	Csk	MONDO|Ensembl=ENSMODG00000009310|UniProtKB=F7GJZ7	Tyrosine-protein kinase	ISS	7687537	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_126324|UniProtKB=C3XYC2	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00049	Parkinson disease	P01211	ERK	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	IDA	10851062	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	HUMAN|HGNC=7576|UniProtKB=P13533	Myosin-6	IEP	10938134	PubMed	PTHR13140:SF721	MYOSIN-6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MACMU|Ensembl=ENSMMUG00000012229|UniProtKB=F6VF32	Uncharacterized protein	ISS	22028976	PubMed	PTHR13140:SF387	MYOSIN-IIIA
P04397	p53 pathway by glucose deprivation	P04636	S6K	XENTR|Xenbase=XB-GENE-482409|UniProtKB=F6UK84	Uncharacterized protein (Fragment)	ISS	15116068	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00010	B cell activation	P00379	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00047	PDGF signaling pathway	P01152	RasGAP	HUMAN|HGNC=9871|UniProtKB=P20936	Ras GTPase-activating protein 1	ISS	8270251	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00010	B cell activation	P00375	Calmodulin	BRAFL|Gene=BRAFLDRAFT_87235|UniProtKB=C3ZEV9	Putative uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	7565716	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00006	Apoptosis signaling pathway	P00269	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	8946911	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00010	B cell activation	P00383	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IDA	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	MONBE|Gene=35258|UniProtKB=A9V782	Serine/threonine-protein phosphatase	ISS	8392016	PubMed	PTHR11668:SF402	SERINE/THREONINE-PROTEIN PHOSPHATASE
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	RCA	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	TAKRU|Ensembl=ENSTRUG00000018599|UniProtKB=H2VEI0	Uncharacterized protein	IDA	11781138	PubMed	PTHR24248:SF111	ALPHA-2B ADRENERGIC RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	BOVIN|Gene=ARRB2|UniProtKB=P32120	Beta-arrestin-2	ISS	11742073	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00023	General transcription regulation	P00662	TFIIA complex	NEUCR|EnsemblGenome=EFNCRG00000009491|UniProtKB=Q7SEH7	Transcription initiation factor IIA subunit 2	ISS	95241493	PubMed	PTHR10966:SF0	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00034	Integrin signalling pathway	P00947	Laminin	HUMAN|HGNC=6487|UniProtKB=P55268	Laminin subunit beta-2	IPI	2538453	PubMed	PTHR10574:SF36	LAMININ SUBUNIT BETA-2
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	TAS	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00059	p53 pathway	P04633	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	IDA	10851062	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05913	Enkephalin release	P05972	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00053	T cell activation	P01332	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01135	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	TAS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	XENTR|Xenbase=XB-GENE-961282|UniProtKB=Q6DF43	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00054	Toll receptor signaling pathway	P01375	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04560	AP1	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	11840290	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00048	PI3 kinase pathway	P01198	FOXO	MOUSE|MGI=MGI=1890081|UniProtKB=Q9WVH4	Forkhead box protein O3	TAS	12048180	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00053	T cell activation	P01311	Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	IDA	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00005	Angiogenesis	P00208	MEKK1	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	ISS	8940199	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00562	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	DANRE|ZFIN=ZDB-GENE-060824-1|UniProtKB=C3PTE8	Beta-arrestin 1	ISS	11742073	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=2446084|UniProtKB=Q8R5M2	Protein Wnt-9a	TAS	11266476	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P00018	EGF receptor signaling pathway	P00545	JNK1-3	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IDA	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P02738	De novo purine biosynthesis	P02889	dGDP kinase	YEAST|SGD=S000001550|UniProtKB=P36010	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00029	Huntington disease	P00790	beta-Tubulin	HUMAN|HGNC=20774|UniProtKB=P04350	Tubulin beta-4A chain	TAS	12932731	PubMed	PTHR11588:SF253	TUBULIN BETA-4A CHAIN
P00004	Alzheimer disease-presenilin pathway	P00114	actin	RAT|RGD=2025|UniProtKB=P68136	Actin, alpha skeletal muscle	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	14526383	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	4506785	gi	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00010	B cell activation	P00402	Jnk	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05913	Enkephalin release	P05974	G-Protein (i)	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	RAT|RGD=619879|UniProtKB=G3V816	Nucleoside diphosphate kinase	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P00034	Integrin signalling pathway	P00906	Rap1	PANTR|Ensembl=ENSPTRG00000011719|UniProtKB=H2QHJ6	Uncharacterized protein	ISS			PTHR24073:SF269	DNAJ HOMOLOG SUBFAMILY C MEMBER 27
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00034	Integrin signalling pathway	P00951	Jnk	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04552	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IDA	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05915	Opioid proenkephalin pathway	P05995	proenkephalin	MACMU|Ensembl=ENSMMUG00000006775|UniProtKB=F7H3N8	Uncharacterized protein	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00014	Cholesterol biosynthesis	P00500	Phosphomevalonate kinase	RAT|RGD=1310812|UniProtKB=Q5RK24	Phosphomevalonate kinase	ISS			PTHR13101:SF1	PHOSPHOMEVALONATE KINASE
P00007	Axon guidance mediated by semaphorins	P00341	Rho	XENTR|Xenbase=XB-GENE-489222|UniProtKB=Q28GJ8	Ras homolog gene family, member A	ISS	15668138	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	HUMAN|HGNC=2347|UniProtKB=O43889	Cyclic AMP-responsive element-binding protein 3	RCA			PTHR22952:SF100	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	HUMAN|HGNC=784|UniProtKB=P15336	Cyclic AMP-dependent transcription factor ATF-2	TAS	9819389	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TAKRU|Ensembl=ENSTRUG00000005447|UniProtKB=P68142	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF354	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00912	Arp2/3	MONDO|Ensembl=ENSMODG00000001303|UniProtKB=F7BZM9	Uncharacterized protein (Fragment)	ISS	12963527	gi	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00055	Transcription regulation by bZIP transcription factor	P01395	TFIIE	CANLF|Ensembl=ENSCAFG00000011306|UniProtKB=E2R3P2	Uncharacterized protein	ISS	92065982	PubMed	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00005	Angiogenesis	P00219	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	DICPU|Gene=DICPUDRAFT_92731|UniProtKB=F0ZWE6	Putative uncharacterized protein rasG	ISS	89128893	PubMed	PTHR24070:SF282	RAS GTPASE-RELATED
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2523|UniProtKB=P25115	D(1B) dopamine receptor	IDA			PTHR43893:SF8	D 1B  DOPAMINE RECEPTOR
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00049	Parkinson disease	P01230	Src kinase	MACMU|Ensembl=ENSMMUG00000000117|UniProtKB=F7H8A7	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF245	TYROSINE-PROTEIN KINASE HCK
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	NEUCR|EnsemblGenome=EFNCRG00000003893|UniProtKB=P78711	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	ORNAN|Ensembl=ENSOANG00000001027|UniProtKB=F6QDY0	Phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00005	Angiogenesis	P00243	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00570	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04398	p53 pathway feedback loops 2	P04665	AKT	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01295	vav	MOUSE|MGI=MGI=1888518|UniProtKB=Q9R0C8	Guanine nucleotide exchange factor VAV3	IDA	14623913	PubMed	PTHR22826:SF97	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	MOUSE|MGI=MGI=97513|UniProtKB=P23188	Furin	IDA	11861638	PubMed	PTHR42884:SF1	FURIN
P06211	BMP/activin signaling pathway-drosophila	P06242	TSG	DROME|FlyBase=FBgn0003865|UniProtKB=P54356	Protein twisted gastrulation	IDA	11260716	PubMed	PTHR12312:SF16	TWISTED GASTRULATION PROTEIN HOMOLOG 1-A-RELATED
P05917	Opioid proopiomelanocortin pathway	P06011	AC	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00017	DNA replication	P00527	Histones	STRPU|EnsemblGenome=SPU_003611|UniProtKB=W4XJN4	Histone H3	ISS	12413958	PubMed	PTHR11426:SF20	HISTONE H3-LIKE CENTROMERIC PROTEIN A
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	CAEEL|WormBase=WBGene00000111|UniProtKB=O44555	Aldehyde dehydrogenase	IC			PTHR43570:SF16	ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q
P00006	Apoptosis signaling pathway	P00274	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	RAT|RGD=69430|UniProtKB=P32851	Syntaxin-1A	TAS	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	HUMAN|HGNC=6026|UniProtKB=P25024	C-X-C chemokine receptor type 1	IC	4504683	gi	PTHR10489:SF916	C-X-C CHEMOKINE RECEPTOR TYPE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00057	Wnt signaling pathway	P01456	beta-arrestin	DROME|FlyBase=FBgn0000120|UniProtKB=P15372	Phosrestin-2	IC	11742073	PubMed	PTHR11792:SF16	PHOSRESTIN-2
P00034	Integrin signalling pathway	P00925	MEK	MONDO|Ensembl=ENSMODG00000008266|UniProtKB=F6Z879	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	MACMU|Ensembl=ENSMMUG00000017022|UniProtKB=F7HQZ9	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00057	Wnt signaling pathway	P01446	Calcineurin	SCHPO|PomBase=SPCC830.06|UniProtKB=Q9UU93	Calcineurin subunit B	ISS	12015605	PubMed	PTHR23056:SF4	PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1
P00004	Alzheimer disease-presenilin pathway	P00148	Erb-B4 N-terminal fragment	MOUSE|MGI=MGI=104771|UniProtKB=Q61527	Receptor tyrosine-protein kinase erbB-4	ISS	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P02738	De novo purine biosynthesis	P02907	dADP kinase	STRCO|EnsemblGenome=CAB75393|UniProtKB=P50589	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05734	Synaptic vesicle trafficking	P05774	NSF	XENTR|Ensembl=ENSXETG00000031364|UniProtKB=F6PIV9	Uncharacterized protein	ISS	7969419	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	DANRE|ZFIN=ZDB-GENE-070705-73|UniProtKB=B8A561	Uncharacterized protein	IC			PTHR13140:SF676	MYOSIN, HEAVY POLYPEPTIDE 2, FAST MUSCLE SPECIFIC
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00025	Hedgehog signaling pathway	P00682	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P06211	BMP/activin signaling pathway-drosophila	P06251	BMP/activin orthologous ligand	DROME|FlyBase=FBgn0024234|UniProtKB=P27091	Protein 60A	RCA	10353905	PubMed	PTHR11848:SF54	PROTEIN 60A-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	RCA	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00006	Apoptosis signaling pathway	P00260	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00924	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00035	Interferon-gamma signaling pathway	P00961	STAT1	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P04393	Ras Pathway	P04547	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IDA	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	DROME|FlyBase=FBgn0000259|UniProtKB=P08182	Casein kinase II subunit beta	IDA	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P04393	Ras Pathway	P04574	PLD	BOVIN|Gene=PLD2|UniProtKB=Q0V8L6	Phospholipase D2	ISS	12615079	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00019	Endothelin signaling pathway	P00590	IP3 R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00006	Apoptosis signaling pathway	P00269	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00029	Huntington disease	P00797	p53	MACMU|Ensembl=ENSMMUG00000016569|UniProtKB=F6VXE7	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00048	PI3 kinase pathway	P01199	Galpha	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00053	T cell activation	P01305	Calmodulin	MONDO|Ensembl=ENSMODG00000002696|UniProtKB=F7CY56	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF335	CALMODULIN, STRIATED MUSCLE
P00005	Angiogenesis	P00215	Nck	MACMU|Ensembl=ENSMMUG00000007389|UniProtKB=F7E0A3	Cytoplasmic protein NCK1 isoform 1	ISS	11689432	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000000843|UniProtKB=H2QZN8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00008	Axon guidance mediated by Slit/Robo	P00344	Netrin	RAT|RGD=619809|UniProtKB=Q924Z9	Netrin-1	IEP	11356879	PubMed	PTHR10574:SF365	NETRIN-1
P02783	Tryptophan biosynthesis	P03209	Anthranilate phosphoribosyl transferase	METAC|EnsemblGenome=MA_2986|UniProtKB=Q8TLP8	Anthranilate synthase, component II	ISS			PTHR43418:SF4	MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN
P00057	Wnt signaling pathway	P01433	SIAH-1	HUMAN|HGNC=10857|UniProtKB=Q8IUQ4	E3 ubiquitin-protein ligase SIAH1	ISS	11389839	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00005	Angiogenesis	P00256	PLC-gamma	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	ISS	14684598	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P02729	Ascorbate degradation	P02849	L-xylulose kinase	DROME|FlyBase=FBgn0038463|UniProtKB=Q9VEQ0	CG3534	ISS			PTHR10196:SF57	XYLULOSE KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02787	Vitamin B6 metabolism	P03236	Pyridoxamine phosphate oxidase	PSEAE|EnsemblGenome=PA1049|UniProtKB=Q9I4S5	Pyridoxine/pyridoxamine 5'-phosphate oxidase	ISS	10984043	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	RCA	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00056	VEGF signaling pathway	P01408	Akt/PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00029	Huntington disease	P00775	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12912997	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01457	GBeta	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IDA	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00021	FGF signaling pathway	P00642	MEK1-2	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00005	Angiogenesis	P00181	SHP2	DANRE|ZFIN=ZDB-GENE-030131-5911|UniProtKB=F1QZU5	Tyrosine-protein phosphatase non-receptor type	ISS	14525967	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IGI	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05913	Enkephalin release	P05977	G-Protein (s)	XENTR|Xenbase=XB-GENE-969601|UniProtKB=Q28H40	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	MACMU|Ensembl=ENSMMUG00000008351|UniProtKB=F7HRV5	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P06959	CCKR signaling map	P07117	BCL2L1	HUMAN|HGNC=992|UniProtKB=Q07817	Bcl-2-like protein 1	RCA	15351698	PubMed	PTHR11256:SF12	BCL-2-LIKE PROTEIN 1
P00053	T cell activation	P01315	Calcineurin	MOUSE|MGI=MGI=107163|UniProtKB=P48453	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	ISS	12015605	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	HUMAN|HGNC=11536|UniProtKB=Q6P1X5	Transcription initiation factor TFIID subunit 2	ISS			PTHR15137:SF9	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	CANLF|Ensembl=ENSCAFG00000012181|UniProtKB=F2Z4N7	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	MOUSE|MGI=MGI=95814|UniProtKB=Q60934	Glutamate receptor ionotropic, kainate 1	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00045	Notch signaling pathway	P01111	LNXp80	MOUSE|MGI=MGI=1278335|UniProtKB=O70263	E3 ubiquitin-protein ligase LNX	IPI	9535908	PubMed	PTHR19964:SF14	E3 UBIQUITIN-PROTEIN LIGASE LNX
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=1561991|UniProtKB=A0A096MJW8	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF51	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00025	Hedgehog signaling pathway	P00692	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00057	Wnt signaling pathway	P01465	Ggamma	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00034	Integrin signalling pathway	P00951	Jnk	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004886|UniProtKB=H2Q5T7	Calcium channel, voltage-dependent, beta 3 subunit	ISS			PTHR11824:SF8	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00828	Galphai	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	RCA			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00572	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02776	Serine glycine biosynthesis	P03159	Phosphoserine phosphatase	METAC|EnsemblGenome=MA_4429|UniProtKB=Q8THT3	Phosphoserine phosphatase	ISS			PTHR43344:SF2	PHOSPHOSERINE PHOSPHATASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	ARATH|TAIR=AT2G42880|UniProtKB=Q9SJG9	Mitogen-activated protein kinase 20	TAS			PTHR24055:SF158	MITOGEN-ACTIVATED PROTEIN KINASE 20
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00036	Interleukin signaling pathway	P00989	Ets	MOUSE|MGI=MGI=98282|UniProtKB=P17433	Transcription factor PU.1	TAS	8970723	PubMed	PTHR11849:SF16	TRANSCRIPTION FACTOR PU.1
P00048	PI3 kinase pathway	P01181	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00006	Apoptosis signaling pathway	P00260	AKT	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	12655147	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01472	Histone deacetylase	MONDO|Ensembl=ENSMODG00000010634|UniProtKB=F7D539	Histone deacetylase	ISS	10485845	PubMed	PTHR10625:SF132	HISTONE DEACETYLASE 3
P02757	O-antigen biosynthesis	P03046	dTDP-glucose pyrophosphorylase	METAC|EnsemblGenome=MA_2183|UniProtKB=Q8TNU5	Glucose-1-phosphate thymidylyltransferase	ISS			PTHR43532:SF3	GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE 2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00521	Profilin	BOVIN|Ensembl=ENSBTAG00000011150|UniProtKB=Q09430	Profilin-2	ISS			PTHR13936:SF15	PROFILIN-2
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00059	p53 pathway	P04612	HDAC1	TAKRU|Ensembl=ENSTRUG00000005364|UniProtKB=H2SKE2	Histone deacetylase	ISS	12665570	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00006	Apoptosis signaling pathway	P00306	TRAF2	PANTR|Ensembl=ENSPTRG00000021578|UniProtKB=H2QY73	TNF receptor-associated factor 2	ISS	8069916	PubMed	PTHR10131:SF21	TNF RECEPTOR-ASSOCIATED FACTOR 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00006	Apoptosis signaling pathway	P00260	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00006	Apoptosis signaling pathway	P00283	A1	HUMAN|HGNC=991|UniProtKB=Q16548	Bcl-2-related protein A1	ISS	11964303	PubMed	PTHR11256:SF10	BCL-2-RELATED PROTEIN A1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	3755548	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02775	Salvage pyrimidine ribonucleotides	P03152	Uridine phosphorylase	DROME|FlyBase=FBgn0031489|UniProtKB=Q0E8U4	FI09636p	ISS			PTHR43691:SF3	URIDINE PHOSPHORYLASE 1
P06959	CCKR signaling map	P07065	PAK1	HUMAN|HGNC=8590|UniProtKB=Q13153	Serine/threonine-protein kinase PAK 1	RCA	17936584	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00005	Angiogenesis	P00249	PAK	XENTR|Xenbase=XB-GENE-966302|UniProtKB=F6T2E7	Uncharacterized protein	ISS	10644687	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P05913	Enkephalin release	P05974	G-Protein (i)	DROME|FlyBase=FBgn0001122|UniProtKB=P16378	G protein alpha o subunit	IC	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04397	p53 pathway by glucose deprivation	P04636	S6K	ORNAN|Ensembl=ENSOANG00000002226|UniProtKB=F6TPX7	Ribosomal protein S6 kinase	ISS	11861821	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IC	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00007	Axon guidance mediated by semaphorins	P00340	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	CAEEL|WormBase=WBGene00000205|UniProtKB=O61861	Actin-related protein 2/3 complex subunit 5	ISS	12473693	PubMed	PTHR12644:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01177	P110ACT	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01294	NFAT	HUMAN|HGNC=7775|UniProtKB=O95644	Nuclear factor of activated T-cells, cytoplasmic 1	IGI	12015605	PubMed	PTHR12533:SF5	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	TAS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00029	Huntington disease	P00777	CBP	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	CAEEL|WormBase=WBGene00000295|UniProtKB=Q9GNP0	Uncharacterized protein	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00010	B cell activation	P00391	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MACMU|Ensembl=ENSMMUG00000017431|UniProtKB=F7HPP3	Uncharacterized protein	ISS	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00057	Wnt signaling pathway	P01457	GBeta	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IDA	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00226	Delta/Serrate	MONDO|Ensembl=ENSMODG00000004910|UniProtKB=F7C1Q4	Delta-like protein	ISS	8955070	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00565	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01173	STAT	CANLF|Ensembl=ENSCAFG00000000163|UniProtKB=F1PAY3	Signal transducer and activator of transcription	ISS	94367369	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	SYNY3|EnsemblGenome=BAA18334|UniProtKB=P74240	Ribonucleoside-diphosphate reductase subunit alpha	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TAKRU|Ensembl=ENSTRUG00000004787|UniProtKB=P53480	Actin, alpha cardiac	IC	14684598	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IGI	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00021	FGF signaling pathway	P00629	PP2A	MONDO|Ensembl=ENSMODG00000014475|UniProtKB=F7A522	Uncharacterized protein (Fragment)	ISS			PTHR10648:SF9	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 65 KDA REGULATORY SUBUNIT A BETA ISOFORM
P00053	T cell activation	P01312	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01176	JAK	MOUSE|MGI=MGI=96629|UniProtKB=Q62120	Tyrosine-protein kinase JAK2	IDA	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P02771	Pyrimidine Metabolism	P03129	Aminotransferase	HUMAN|HGNC=23|UniProtKB=P80404	4-aminobutyrate aminotransferase, mitochondrial	IDA	10989446	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P02749	Leucine biosynthesis	P03001	3-Isopropylmalate dehydrogenase	BACTN|EnsemblGenome=BT_1857|UniProtKB=Q8A6M0	3-isopropylmalate dehydrogenase	ISS			PTHR42979:SF1	3-ISOPROPYLMALATE DEHYDROGENASE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00047	PDGF signaling pathway	P01153	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	G01511	SPRY	CANLF|Ensembl=ENSCAFG00000005260|UniProtKB=E2RGU9	Uncharacterized protein	ISS	12225946	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P02746	Heme biosynthesis	P02974	Uroporphyrinogen-III synthase	YEAST|SGD=S000005804|UniProtKB=P06174	Uroporphyrinogen-III synthase	ISS			PTHR12390:SF0	UROPORPHYRINOGEN-III SYNTHASE
P00021	FGF signaling pathway	P00633	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	3035212	PubMed	PTHR24070:SF385	GTPASE HRAS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00012	Cadherin signaling pathway	P00474	Wnt	RAT|RGD=1304559|UniProtKB=D4A3W9	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P00006	Apoptosis signaling pathway	P00277	Bi1	DROME|FlyBase=FBgn0035871|UniProtKB=Q9VSH3	Bax inhibitor 1	ISS			PTHR23291:SF34	BAX INHIBITOR 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347736|UniProtKB=E9FRT1	Muscle-specific actin	ISS	14684598	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P02746	Heme biosynthesis	P02970	Coproporphyrinogen oxidase (oxygen independent)	ECOLI|EcoGene=EG12983|UniProtKB=P52062	Oxygen-independent coproporphyrinogen-III oxidase-like protein YggW	ISS			PTHR13932:SF5	OXYGEN-INDEPENDENT COPROPORPHYRINOGEN-III OXIDASE-LIKE PROTEIN YGGW
P00059	p53 pathway	G04694	p110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00011	Blood coagulation	P00443	Fibrin polymer cross-linked	PANTR|Ensembl=ENSPTRG00000016534|UniProtKB=H2QQB4	Uncharacterized protein	ISS	6575700	PubMed	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00048	PI3 kinase pathway	P01181	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00029	Huntington disease	P00807	Actin	CHICK|Ensembl=ENSGALG00000009621|UniProtKB=P60706	Actin, cytoplasmic 1	ISS	11889139	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	TAS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00057	Wnt signaling pathway	P01448	CBP	ARATH|TAIR=AT1G67220|UniProtKB=Q9FYH1	Histone acetyltransferase HAC2	IDA	10664585	PubMed	PTHR13808:SF6	HISTONE ACETYLTRANSFERASE HAC2
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IGI	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	ORNAN|Ensembl=ENSOANG00000007405|UniProtKB=F7CIV4	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00053	T cell activation	P01332	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	TAS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	IDA	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	10514528	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00054	Toll receptor signaling pathway	P01352	p38	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00053	T cell activation	P01294	NFAT	PANTR|Ensembl=ENSPTRG00000008260|UniProtKB=H2QBD7	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	ISS	9133421	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P02732	Coenzyme A linked carnitine metabolism	P02864	L-carnitine dehydratase	MACMU|Ensembl=ENSMMUG00000001702|UniProtKB=F7FZV9	Uncharacterized protein	ISS			PTHR43949:SF6	SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE
P00015	Circadian clock system	P00505	Cry	MACMU|Ensembl=ENSMMUG00000002453|UniProtKB=F7HH05	Cryptochrome-2	ISS	11804325	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	DROME|FlyBase=FBgn0010051|UniProtKB=P29993	Inositol 1,4,5-trisphosphate receptor	IDA	9065779	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IGI	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Ensembl=ENSCAFG00000013755|UniProtKB=Q49LX5	Somatostatin receptor type 1	ISS	12441358	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	ARATH|TAIR=AT1G13890|UniProtKB=Q9LMG8	Putative SNAP25 homologous protein SNAP30	ISS	9070898	PubMed	PTHR19305:SF7	SNAP25 HOMOLOGOUS PROTEIN SNAP30-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00563	Gab	PANTR|Ensembl=ENSPTRG00000004115|UniProtKB=H2R3E1	GRB2-associated binding protein 2	ISS	6753932	gi	PTHR12156:SF4	GRB2-ASSOCIATED-BINDING PROTEIN 2
P00005	Angiogenesis	P00238	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	91232861	PubMed	PTHR24070:SF385	GTPASE HRAS
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000000365|UniProtKB=F6R9F4	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00047	PDGF signaling pathway	P01140	ELK	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	14670631	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	HUMAN|HGNC=9193|UniProtKB=P61218	DNA-directed RNA polymerases I, II, and III subunit RPABC2	ISS	415387	gi	PTHR10773:SF12	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2
P00004	Alzheimer disease-presenilin pathway	P00165	E-cadherin N-terminal fragment	RAT|RGD=69279|UniProtKB=Q9R0T4	Cadherin-1	TAS	11953314	PubMed	PTHR24027:SF319	CADHERIN-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04398	p53 pathway feedback loops 2	P04668	p53	MOUSE|MGI=MGI=1336991|UniProtKB=Q9JJP2	Tumor protein p73	TAS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00059	p53 pathway	P04609	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00590	IP3 R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	IGI	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	LEIMA|EnsemblGenome=LmjF.09.0910|UniProtKB=Q4QHT2	Putative calmodulin	ISS	7514101	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	IC	15737619	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00018	EGF receptor signaling pathway	P00543	ERK1-2	ARATH|TAIR=AT2G42880|UniProtKB=Q9SJG9	Mitogen-activated protein kinase 20	ISS			PTHR24055:SF158	MITOGEN-ACTIVATED PROTEIN KINASE 20
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02763	Peptidoglycan biosynthesis	P03090	N-Acetylglucosaminyl transferase	ECOLI|EcoGene=EG10623|UniProtKB=P17443	UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase	ISS			PTHR21015:SF22	GLYCOSYLTRANSFERASE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04393	Ras Pathway	P04556	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_127489|UniProtKB=C3XYC6	Putative uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IGI	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	IC	88311074	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02723	Adenine and hypoxanthine salvage pathway	P02809	Xanthine dehydrogenase	HUMAN|HGNC=12805|UniProtKB=P47989	Xanthine dehydrogenase/oxidase	ISS	12969896	PubMed	PTHR11908:SF80	XANTHINE DEHYDROGENASE/OXIDASE
P00022	General transcription by RNA polymerase I	P00656	PTRF	MACMU|Ensembl=ENSMMUG00000029994|UniProtKB=F7HJ72	Uncharacterized protein	ISS	603198	OMIM	PTHR15240:SF3	POLYMERASE I AND TRANSCRIPT RELEASE FACTOR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00715	AGS3	PANTR|Ensembl=ENSPTRG00000001037|UniProtKB=H2PZJ5	G-protein signaling modulator 2	ISS	11121039	PubMed	PTHR10098:SF100	G-PROTEIN-SIGNALING MODULATOR 2
P00029	Huntington disease	P00778	NMDA receptor	PANTR|Ensembl=ENSPTRG00000004718|UniProtKB=H2Q5I0	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00005	Angiogenesis	P00189	Fzd	PANTR|Ensembl=ENSPTRG00000020122|UniProtKB=H2QVZ0	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF22	FRIZZLED-3
P00006	Apoptosis signaling pathway	P00260	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02724	Alanine biosynthesis	P02815	Branched chain amino acid aminotransferase	MOUSE|MGI=MGI=104861|UniProtKB=P24288	Branched-chain-amino-acid aminotransferase, cytosolic	ISS			PTHR11825:SF51	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, CYTOSOLIC
P00034	Integrin signalling pathway	P00930	Dock180	CAEEL|WormBase=WBGene00000419|UniProtKB=G5EEN3	CED-5	IDA			PTHR23317:SF69	MYOBLAST CITY, ISOFORM B
P00029	Huntington disease	P00799	JNK-2	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	YEAST|SGD=S000004780|UniProtKB=P47771	Aldehyde dehydrogenase [NAD(P)+] 1	IC			PTHR43720:SF1	ALDEHYDE DEHYDROGENASE  NAD P +  1-RELATED
P00053	T cell activation	P01324	rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P06664	Gonadotropin-releasing hormone receptor pathway	P06709	FOS	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	RCA	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00048	PI3 kinase pathway	P01199	Galpha	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00029	Huntington disease	P00806	TAFII130	HUMAN|HGNC=11537|UniProtKB=O00268	Transcription initiation factor TFIID subunit 4	IDA	10973244	PubMed	PTHR15138:SF18	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	CHICK|Ensembl=ENSGALG00000009705|UniProtKB=F1NSR9	Uncharacterized protein	ISS	15858232	PubMed	PTHR13715:SF16	RYANODINE RECEPTOR 3
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	IC	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00052	TGF-beta signaling pathway	P01284	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02763	Peptidoglycan biosynthesis	P03090	N-Acetylglucosaminyl transferase	CHLTR|EnsemblGenome=CT_761|UniProtKB=O84766	UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase	ISS			PTHR21015:SF22	GLYCOSYLTRANSFERASE
P00029	Huntington disease	P00780	Microtubule	CANLF|Ensembl=ENSCAFG00000018832|UniProtKB=E2QYC2	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00036	Interleukin signaling pathway	P00976	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MOUSE|MGI=MGI=95770|UniProtKB=P30678	Guanine nucleotide-binding protein subunit alpha-15	IDA	11534853	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2747|UniProtKB=P35349	Metabotropic glutamate receptor 6	IDA	11431030	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	SCHPO|PomBase=SPAC8C9.03|UniProtKB=P36600	cAMP-dependent protein kinase regulatory subunit	IC	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00053	T cell activation	P01327	Gads	HUMAN|HGNC=4563|UniProtKB=O75791	GRB2-related adapter protein 2	IPI	10021361	PubMed	PTHR24418:SF299	GRB2-RELATED ADAPTER PROTEIN 2
P00024	Glycolysis	P00677	Hexokinase	MACMU|Ensembl=ENSMMUG00000011845|UniProtKB=F7H4Y8	Uncharacterized protein	RCA			PTHR19443:SF4	HEXOKINASE-2
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00030	Hypoxia response via HIF activation	P00821	Prolyl Hydroxylase	MOUSE|MGI=MGI=1932287|UniProtKB=Q91YE2	Egl nine homolog 2	IDA	12912907	PubMed	PTHR12907:SF6	EGL NINE HOMOLOG 2
P00036	Interleukin signaling pathway	P00975	RasGAP	HUMAN|HGNC=9871|UniProtKB=P20936	Ras GTPase-activating protein 1	IC	8270251	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04392	P53 pathway feedback loops 1	P04539	p53	PANTR|Ensembl=ENSPTRG00000008703|UniProtKB=H2QC53	Cellular tumor antigen p53	ISS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00019	Endothelin signaling pathway	P00572	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	HUMAN|HGNC=6843|UniProtKB=P46734	Dual specificity mitogen-activated protein kinase kinase 3	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	RCA	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00235	c-Fos	DANRE|ZFIN=ZDB-GENE-031222-4|UniProtKB=Q6P0S4	Uncharacterized protein	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4388|UniProtKB=P38405	Guanine nucleotide-binding protein G(olf) subunit alpha	IC	6309844	PubMed	PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	ANOGA|EnsemblGenome=AGAP010457|UniProtKB=Q7QDW7	AGAP010457-PA	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00019	Endothelin signaling pathway	P00572	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MACMU|Ensembl=ENSMMUG00000006253|UniProtKB=F7H582	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00029	Huntington disease	P00799	JNK-2	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	BOVIN|Ensembl=ENSBTAG00000039794|UniProtKB=P35507	Casein kinase I isoform beta	IDA	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00005	Angiogenesis	P00238	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00053	T cell activation	P01309	fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	TAS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00034	Integrin signalling pathway	P00944	Actin	MACMU|Ensembl=ENSMMUG00000012054|UniProtKB=F6TII3	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00010	B cell activation	P00376	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P02738	De novo purine biosynthesis	P02891	GDP kinase	CHLTR|EnsemblGenome=CT_500|UniProtKB=O84508	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00005	Angiogenesis	P00203	Erk	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01159	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00036	Interleukin signaling pathway	P00968	Ikk	HUMAN|HGNC=1974|UniProtKB=O15111	Inhibitor of nuclear factor kappa-B kinase subunit alpha	IC	14499113	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	BOVIN|Gene=ACVR2B|UniProtKB=Q95126	Activin receptor type-2B	TAS	11252892	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P00047	PDGF signaling pathway	P01154	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	SCLS1|EnsemblGenome=SS1G_03482|UniProtKB=A7EDU2	Guanine nucleotide-binding protein beta subunit	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	RCA			PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=17175|UniProtKB=Q9P212	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	12860966	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	TAS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00021	FGF signaling pathway	P00645	Rac	DICDI|dictyBase=DDB_G0277869|UniProtKB=P34144	Rho-related protein rac1A	ISS	94124042	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00005	Angiogenesis	P00223	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	IC	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00048	PI3 kinase pathway	P01202	p85	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	IC	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05918	p38 MAPK pathway	P06031	p38alpha	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CAEEL|WormBase=WBGene00001187|UniProtKB=Q8MQA1	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P05918	p38 MAPK pathway	P06026	MEKK4	HUMAN|HGNC=6856|UniProtKB=Q9Y6R4	Mitogen-activated protein kinase kinase kinase 4	IDA	9305639	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00019	Endothelin signaling pathway	P00570	PKA	YEAST|SGD=S000001295|UniProtKB=P07278	cAMP-dependent protein kinase regulatory subunit	ISS	2372396	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01413	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	YEAST|SGD=S000005854|UniProtKB=P33328	Synaptobrevin homolog 2	IC			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=94926|UniProtKB=P51436	D(4) dopamine receptor	IDA	2137198	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00019	Endothelin signaling pathway	P00587	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P06587	Nicotine pharmacodynamics pathway	P06605	KCNK3/9	BOVIN|Ensembl=ENSBTAG00000018193|UniProtKB=E1BHX8	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g169611|UniProtKB=A7SEB1	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	TAS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00023	General transcription regulation	P00658	TBP-associated factors	HUMAN|HGNC=11545|UniProtKB=Q16514	Transcription initiation factor TFIID subunit 12	ISS			PTHR12264:SF21	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2744|UniProtKB=P31422	Metabotropic glutamate receptor 3	IDA	9407094	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00029	Huntington disease	P00780	Microtubule	SCHMA|EnsemblGenome=Smp_192110|UniProtKB=G4VHK8	Putative tubulin beta chain	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	TAS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	HUMAN|HGNC=11532|UniProtKB=Q15573	TATA box-binding protein-associated factor RNA polymerase I subunit A	ISS	10894955	PubMed	PTHR32122:SF1	TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT A
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	ARATH|TAIR=AT3G57080|UniProtKB=Q9M1J2	DNA-directed RNA polymerase V subunit 5A	ISS	11313498	gi	PTHR10535:SF2	DNA-DIRECTED RNA POLYMERASE V SUBUNIT 5A-RELATED
P04395	Vasopressin synthesis	P04593	Glycopeptide	MOUSE|MGI=MGI=97453|UniProtKB=P35454	Oxytocin-neurophysin 1	IC	1706187	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	XENTR|Xenbase=XB-GENE-976753|UniProtKB=Q0VFR6	Syntaxin 1A (Brain)	ISS	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	BOVIN|Gene=MYH7|UniProtKB=Q9BE39	Myosin-7	IC	89264452	PubMed	PTHR13140:SF344	MYOSIN-7
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00057	Wnt signaling pathway	P01443	Phospholipase C	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01322	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01084	CHT1	DROME|FlyBase=FBgn0038641|UniProtKB=Q9VE46	High-affinity choline transporter 1	RCA			PTHR11819:SF12	HIGH-AFFINITY CHOLINE TRANSPORTER 1
P00018	EGF receptor signaling pathway	P00539	14-3-3	PANTR|Ensembl=ENSPTRG00000013529|UniProtKB=H2R8X6	Uncharacterized protein	ISS	1671102	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00059	p53 pathway	P01486	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00474	Wnt	MACMU|Ensembl=ENSMMUG00000015705|UniProtKB=F6SM00	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	RAT|RGD=619879|UniProtKB=G3V816	Nucleoside diphosphate kinase	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00024	Glycolysis	P00671	Phosphoglycerate kinase	YARLI|Gene=YALI0D12400g|UniProtKB=P29407	Phosphoglycerate kinase	IDA	96207469	PubMed	PTHR11406:SF0	PHOSPHOGLYCERATE KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000012005|UniProtKB=F7H091	Metabotropic glutamate receptor 2 isoform a	ISS	12488551	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00053	T cell activation	P01299	TCR Beta	BOVIN|Ensembl=ENSBTAG00000047072|UniProtKB=G3MY18	Uncharacterized protein	IDA			PTHR23268:SF6	SUBFAMILY NOT NAMED
P00049	Parkinson disease	P01233	Elk-1	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	3183861	gi	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	RAT|RGD=68942|UniProtKB=O54898	Voltage-dependent T-type calcium channel subunit alpha-1G	ISS	18021322	PubMed	PTHR10037:SF137	VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1G
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	HUMAN|HGNC=1955|UniProtKB=P02708	Acetylcholine receptor subunit alpha	ISS	85270494	PubMed	PTHR18945:SF74	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA
P00008	Axon guidance mediated by Slit/Robo	P00355	Rho	DROME|FlyBase=FBgn0014020|UniProtKB=P48148	Ras-like GTP-binding protein Rho1	ISS	11973360	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	9298898	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00260	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00038	JAK/STAT signaling pathway	P01029	Serine kinase	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	ISS			PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00059	p53 pathway	P04633	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01173	STAT	TAKRU|Ensembl=ENSTRUG00000000102|UniProtKB=H2RJA9	Signal transducer and activator of transcription	ISS	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04550	Ral	DANRE|ZFIN=ZDB-GENE-040426-1344|UniProtKB=Q7T383	Rala protein	ISS	11025226	PubMed	PTHR24070:SF174	RAS-RELATED PROTEIN RAL-A
P00006	Apoptosis signaling pathway	P00269	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00172	BACE-1	HUMAN|HGNC=933|UniProtKB=P56817	Beta-secretase 1	IDA	10956649	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04398	p53 pathway feedback loops 2	P04660	SIAH-1	RAT|RGD=620449|UniProtKB=Q920M9	E3 ubiquitin-protein ligase SIAH1	ISS	11389839	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01006	NR2C	MOUSE|MGI=MGI=95822|UniProtKB=Q01098	Glutamate receptor ionotropic, NMDA 2C	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00025	Hedgehog signaling pathway	P00682	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	IDA	188830	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00223	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00023	General transcription regulation	P00662	TFIIA complex	PANTR|Ensembl=ENSPTRG00000039894|UniProtKB=H2RAZ7	Uncharacterized protein	ISS			PTHR12694:SF9	PROTEIN STON1-GTF2A1L-RELATED
P00030	Hypoxia response via HIF activation	P00814	P300	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	IDA	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00036	Interleukin signaling pathway	P00973	PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CAEBR|Gene=CBG01949|UniProtKB=A8WRN3	Protein CBR-MGL-1 (Fragment)	ISS	12488551	PubMed	PTHR24060:SF137	METABOTROPIC GLUTAMATE RECEPTOR
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00056	VEGF signaling pathway	P01408	Akt/PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000002125|UniProtKB=F1N461	Uncharacterized protein	ISS	2106672	PubMed	PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P05915	Opioid proenkephalin pathway	P05994	G-protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	10188796	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00036	Interleukin signaling pathway	P00981	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00049	Parkinson disease	P01208	Hsp70	PHYPA|Gene=PHYPADRAFT_158543|UniProtKB=A9RCV9	Predicted protein	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00052	TGF-beta signaling pathway	P01275	P38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00010	B cell activation	P00385	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00047	PDGF signaling pathway	P01174	Rho	BOVIN|Ensembl=ENSBTAG00000002531|UniProtKB=Q08DP6	Rho GTPase-activating protein 10	ISS	8649427	PubMed	PTHR12552:SF5	RHO GTPASE-ACTIVATING PROTEIN 10
P05730	Endogenous cannabinoid signaling	P05751	Galpha	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	CHICK|Gene=JUN|UniProtKB=P18870	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P02762	Pentose phosphate pathway	P03079	Hexokinase	YEAST|SGD=S000004438|UniProtKB=Q06204	Putative hexokinase YLR446W	ISS	9169871	PubMed	PTHR19443:SF24	HEXOKINASE YLR446W-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04386	Histamine H2 receptor mediated signaling pathway	P04489	H2	HUMAN|HGNC=5183|UniProtKB=P25021	Histamine H2 receptor	ISS	8817552	PubMed	PTHR43893:SF5	HISTAMINE H2 RECEPTOR
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	PANTR|Ensembl=ENSPTRG00000023608|UniProtKB=H2QZZ2	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00012	Cadherin signaling pathway	P00466	EGFR	HUMAN|HGNC=3236|UniProtKB=P00533	Epidermal growth factor receptor	ISS	21100872	PubMed	PTHR24416:SF91	EPIDERMAL GROWTH FACTOR RECEPTOR
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00034	Integrin signalling pathway	P00919	Arf6	DANRE|ZFIN=ZDB-GENE-030131-8007|UniProtKB=Q6P2U5	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00005	Angiogenesis	P00233	CSL	CHICK|Ensembl=ENSGALG00000014365|UniProtKB=F1NIJ8	Uncharacterized protein	ISS	12145413	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00019	Endothelin signaling pathway	P00586	Gq	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	HUMAN|HGNC=7852|UniProtKB=O00746	Nucleoside diphosphate kinase, mitochondrial	ISS			PTHR11349:SF49	NUCLEOSIDE DIPHOSPHATE KINASE, MITOCHONDRIAL
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01192	p110	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00551	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04558	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04393	Ras Pathway	P04578	Rho	MONDO|Ensembl=ENSMODG00000000981|UniProtKB=F7ES59	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00021	FGF signaling pathway	P00641	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00019	Endothelin signaling pathway	P00586	Gq	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	1333286	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00053	T cell activation	P01305	Calmodulin	STRPU|EnsemblGenome=SPU_005033|UniProtKB=W4XNQ0	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF263	SUBFAMILY NOT NAMED
P00054	Toll receptor signaling pathway	P01369	MKK1	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00006	Apoptosis signaling pathway	P00269	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	97442349	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT2G18170|UniProtKB=Q39027	Mitogen-activated protein kinase 7	ISS	11707292	PubMed	PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P00006	Apoptosis signaling pathway	P00274	JNK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02738	De novo purine biosynthesis	P02909	GDP reductase	SCHPO|PomBase=SPBC25D12.04|UniProtKB=P36603	Ribonucleoside-diphosphate reductase small chain	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00006	Apoptosis signaling pathway	P00304	XIAP	PANTR|Ensembl=ENSPTRG00000022247|UniProtKB=H2QZ31	Uncharacterized protein	ISS			PTHR10044:SF115	BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 8-RELATED
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00056	VEGF signaling pathway	P01422	eNOS	HUMAN|HGNC=7876|UniProtKB=P29474	Nitric oxide synthase, endothelial	IEP	10435050	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	PSEAE|EnsemblGenome=PA3807|UniProtKB=Q59636	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05913	Enkephalin release	P05974	G-Protein (i)	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	PANTR|Ensembl=ENSPTRG00000002979|UniProtKB=H2Q2M8	Uncharacterized protein	ISS	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00007	Axon guidance mediated by semaphorins	P00340	Rac	MACMU|Ensembl=ENSMMUG00000021075|UniProtKB=F7GY91	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00005	Angiogenesis	P00223	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IGI	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	ARATH|TAIR=AT3G60250|UniProtKB=O81275	Casein kinase II subunit beta-3	IDA	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000025373|UniProtKB=F6ZZG9	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00021	FGF signaling pathway	P00645	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	15470041	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	LEIMA|EnsemblGenome=LmjF.35.4010|UniProtKB=Q9GNR4	Protein kinase A catalytic subunit isoform 1	ISS	10218114	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00221	JNK1	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS			PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P02771	Pyrimidine Metabolism	P03131	5'-Nucleotidase	RAT|RGD=61956|UniProtKB=P21588	5'-nucleotidase	RCA	3219501	gi	PTHR11575:SF25	5'-NUCLEOTIDASE
P00038	JAK/STAT signaling pathway	P01027	STAT	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	ISS	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	ISS	1333286	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	IDA	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	IC	11535291	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00018	EGF receptor signaling pathway	P00552	Ras	DICDI|dictyBase=DDB_G0277381|UniProtKB=Q75J93	Circularly permutated Ras protein 1	ISS			PTHR24070:SF385	GTPASE HRAS
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CAEBR|Gene=CBG02401|UniProtKB=A8WUE7	Protein CBR-NMR-1	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04398	p53 pathway feedback loops 2	P04658	PTEN	DICDI|dictyBase=DDB_G0286557|UniProtKB=Q8T9S7	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI			PTHR12305:SF79	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00047	PDGF signaling pathway	P01162	MEK	CAEEL|WormBase=WBGene00003186|UniProtKB=Q10664	Dual specificity mitogen-activated protein kinase kinase mek-2	ISS	22022015	PubMed	PTHR24361:SF629	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000004742|UniProtKB=H2Q5K1	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P00047	PDGF signaling pathway	P01171	PLCgamma	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	10891487	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	MOUSE|MGI=MGI=96616|UniProtKB=P26011	Integrin beta-7	ISS	12391210	PubMed	PTHR10082:SF36	INTEGRIN BETA-7
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	RAT|RGD=1303282|UniProtKB=Q6MG89	Notch homolog 4, [Drosophila]	ISS	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00045	Notch signaling pathway	G01541	E(spl)-C genes	DANRE|ZFIN=ZDB-GENE-000526-1|UniProtKB=Q9I9L0	Hairy/enhancer-of-split related with YRPW motif protein 2	IC			PTHR10985:SF88	HAIRY/ENHANCER-OF-SPLIT RELATED WITH YRPW MOTIF PROTEIN 2
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	CRYNJ|Gene=CNJ01940|UniProtKB=Q07801	Dihydrofolate reductase	ISS			PTHR22778:SF16	DIHYDROFOLATE REDUCTASE
P00057	Wnt signaling pathway	P01443	Phospholipase C	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04398	p53 pathway feedback loops 2	G04714	PTEN	XENTR|Xenbase=XB-GENE-491433|UniProtKB=B1H2U0	Pten protein	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00052	TGF-beta signaling pathway	P01286	TGFbeta	HUMAN|HGNC=1069|UniProtKB=P12643	Bone morphogenetic protein 2	TAS	9759503	PubMed	PTHR11848:SF143	BONE MORPHOGENETIC PROTEIN 2
P00053	T cell activation	P01306	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00047	PDGF signaling pathway	P01152	RasGAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	ISS	2574500	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CANLF|Ensembl=ENSCAFG00000000443|UniProtKB=E2QSF4	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00034	Integrin signalling pathway	P00923	Arf1	CHLRE|EnsemblGenome=CHLREDRAFT_186126|UniProtKB=A8IL29	Small ARF-related GTPase	IPI	11752622	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	14526383	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=1305438|UniProtKB=Q5DWV1	Cadherin-20	ISS	8120095	PubMed	PTHR24027:SF84	CADHERIN-20
P00037	Ionotropic glutamate receptor pathway	P01023	CaMKII	CHICK|Ensembl=ENSGALG00000005621|UniProtKB=F1NGS8	Uncharacterized protein	ISS	12888804	PubMed	PTHR43940:SF5	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA
P02738	De novo purine biosynthesis	P02892	5-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase	PANTR|Ensembl=ENSPTRG00000014407|UniProtKB=H2QLR3	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	BOVIN|Ensembl=ENSBTAG00000037794|UniProtKB=E1BP87	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF681	MYOSIN-4
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MONDO|Ensembl=ENSMODG00000009514|UniProtKB=F7EVK3	Uncharacterized protein	ISS	15218628	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ORYSJ|EnsemblGenome=OS12G0163700|UniProtKB=Q0IPW3	Os12g0163700 protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00029	Huntington disease	P00807	Actin	MOUSE|MGI=MGI=2444552|UniProtKB=Q8BFZ3	Beta-actin-like protein 2	IDA	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00139	E-cadherin transmembrane fragment	RAT|RGD=621089|UniProtKB=F1LMI3	Cadherin 3, type 1, P-cadherin (Placental)	ISS	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P05734	Synaptic vesicle trafficking	P05778	SNAP-25	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	TAS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00047	PDGF signaling pathway	P01164	PDK1/2	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	ISS	15210700	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	DROME|FlyBase=FBgn0010399|UniProtKB=Q24418	Glutamate [NMDA] receptor subunit 1	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00057	Wnt signaling pathway	P01438	PP2A	TAKRU|Ensembl=ENSTRUG00000011169|UniProtKB=H2TU36	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00623	FGF	MONDO|Ensembl=ENSMODG00000006282|UniProtKB=F7F0I1	Fibroblast growth factor	ISS			PTHR11486:SF18	FIBROBLAST GROWTH FACTOR 14
P00048	PI3 kinase pathway	P01177	P110ACT	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00183	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	7798194	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00046	Oxidative stress response	P01129	JNK1/2	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	TAS	7600581	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00049	Parkinson disease	P01211	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00012	Cadherin signaling pathway	P00464	Fyn	CHICK|Gene=FYN|UniProtKB=Q05876	Tyrosine-protein kinase Fyn	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00474	Wnt	BOVIN|Ensembl=ENSBTAG00000002664|UniProtKB=F1N7G3	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF84	PROTEIN WNT-9B
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00046	Oxidative stress response	P01129	JNK1/2	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00024	Glycolysis	P00678	Enolase	PANTR|Ensembl=ENSPTRG00000000109|UniProtKB=G2HFA5	Alpha-enolase	ISS	89079778	PubMed	PTHR11902:SF12	ALPHA-ENOLASE
P00046	Oxidative stress response	P01135	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00010	B cell activation	P00376	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P04398	p53 pathway feedback loops 2	P04664	cyclin E	MACMU|Ensembl=ENSMMUG00000020668|UniProtKB=F7BEI4	Uncharacterized protein	ISS	12628165	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00057	Wnt signaling pathway	P01443	Phospholipase C	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	RAT|RGD=2944|UniProtKB=P24898	Transcription factor jun-B	ISS	10664585	PubMed	PTHR11462:SF37	TRANSCRIPTION FACTOR JUN-B
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02749	Leucine biosynthesis	P03000	Branched chain amino acid aminotransferase	HALSA|EnsemblGenome=VNG_2122G|UniProtKB=Q9HNF8	Branched-chain amino acid aminotransferase	ISS			PTHR42743:SF3	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE-LIKE PROTEIN 1-RELATED
P06664	Gonadotropin-releasing hormone receptor pathway	P06785	ELK1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	RCA	3183861	gi	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04395	Vasopressin synthesis	P04590	Vasopressin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00029	Huntington disease	P00775	Rac	EMENI|EnsemblGenome=CADANIAG00000581|UniProtKB=G5EAY4	CD42_CHICK Cell division control protein 42 homolog (G25K GTP-binding protein)	TAS			PTHR24072:SF192	CDC42 HOMOLOG
P00045	Notch signaling pathway	P01104	Serrate	XENTR|Xenbase=XB-GENE-485662|UniProtKB=F7ENN2	Delta-like protein	ISS	11685570	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P05916	Opioid prodynorphin pathway	P06001	AC	RAT|RGD=619966|UniProtKB=F1LQT1	Adenylate cyclase 7	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00047	PDGF signaling pathway	P01162	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05913	Enkephalin release	P05977	G-Protein (s)	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00054	Toll receptor signaling pathway	P01366	MKK4	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00010	B cell activation	P00375	Calmodulin	CANLF|Ensembl=ENSCAFG00000030049|UniProtKB=J9NWQ5	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF311	CALMODULIN
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IGI	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00034	Integrin signalling pathway	P00924	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000023940|UniProtKB=F6RFW8	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00009	Axon guidance mediated by netrin	P00366	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00010	B cell activation	P00386	Calcineurin	XENTR|Xenbase=XB-GENE-952299|UniProtKB=B0BLZ8	Serine/threonine-protein phosphatase	ISS	12091710	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	HUMAN|HGNC=4586|UniProtKB=Q13224	Glutamate receptor ionotropic, NMDA 2B	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00022	General transcription by RNA polymerase I	P00652	RNA Polymerase I  Complex	PANTR|Ensembl=ENSPTRG00000020470|UniProtKB=H2QWI2	Polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa	ISS	12634356	PubMed	PTHR12056:SF2	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MOUSE|MGI=MGI=87904|UniProtKB=P60710	Actin, cytoplasmic 1	IC	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00023	General transcription regulation	P00666	TFIIE	RAT|RGD=1306851|UniProtKB=G3V992	General transcription factor II E, polypeptide 1 (Alpha subunit)	ISS	189962	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P02738	De novo purine biosynthesis	P02900	AICAR transformylase	MACMU|Ensembl=ENSMMUG00000012318|UniProtKB=F7DFY8	Uncharacterized protein	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00006	Apoptosis signaling pathway	P00317	Fos	DANRE|ZFIN=ZDB-GENE-031222-4|UniProtKB=Q6P0S4	Uncharacterized protein	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00006	Apoptosis signaling pathway	P00274	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	P01457	GBeta	DROME|FlyBase=FBgn0001105|UniProtKB=P26308	Guanine nucleotide-binding protein subunit beta-1	IDA	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00634	MEKK1-5	BOVIN|Ensembl=ENSBTAG00000004216|UniProtKB=F1MSX4	Uncharacterized protein	ISS	21735556	gi	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00010	B cell activation	P00384	p38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00034	Integrin signalling pathway	P00940	Src	STRPU|EnsemblGenome=SPU_013522|UniProtKB=Q8WQM5	Tyrosine-protein kinase	IPI	8054685	PubMed	PTHR24418:SF292	TYROSINE-PROTEIN KINASE SRC42A
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00025	Hedgehog signaling pathway	P00683	Slimb	CHICK|Ensembl=ENSGALG00000002229|UniProtKB=F1P5E8	Uncharacterized protein	ISS	12628165	PubMed	PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P00010	B cell activation	P00400	Btk	CANLF|Ensembl=ENSCAFG00000017669|UniProtKB=E2RMF7	Tyrosine-protein kinase	ISS	10521450	PubMed	PTHR24418:SF92	TYROSINE-PROTEIN KINASE BTK
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	ISS	8836152	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00739	AGS3	PANTR|Ensembl=ENSPTRG00000001037|UniProtKB=H2PZJ5	G-protein signaling modulator 2	ISS	11121039	PubMed	PTHR10098:SF100	G-PROTEIN-SIGNALING MODULATOR 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	DROME|FlyBase=FBgn0024814|UniProtKB=Q9VWA1	Clathrin light chain	IDA	11889126	PubMed	PTHR10639:SF7	CLATHRIN LIGHT CHAIN
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CHICK|Ensembl=ENSGALG00000011086|UniProtKB=P68139	Actin, alpha skeletal muscle	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00005	Angiogenesis	P00219	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00057	Wnt signaling pathway	P01451	Galpha	RAT|RGD=619751|UniProtKB=O88302	Guanine nucleotide-binding protein subunit alpha-15	IDA	8838318	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P00006	Apoptosis signaling pathway	P00269	MAPK	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00059	p53 pathway	P04616	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	9094314	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P02770	Pyridoxal phosphate salvage pathway	P03122	Pyridoxamine kinase	HUMAN|HGNC=8819|UniProtKB=O00764	Pyridoxal kinase	ISS	15082224	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P04393	Ras Pathway	P04572	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MOUSE|MGI=MGI=1915339|UniProtKB=P59999	Actin-related protein 2/3 complex subunit 4	ISS	5031595	gi	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	RAT|RGD=2738|UniProtKB=Q00960	Glutamate receptor ionotropic, NMDA 2B	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	HUMAN|HGNC=9508|UniProtKB=P49768	Presenilin-1	IDA	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	13620175	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Gene=GRIK4|UniProtKB=Q5IS46	Glutamate receptor ionotropic, kainate 4	ISS	12941441	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00029	Huntington disease	P00811	Arp2/3 complex	HUMAN|HGNC=23366|UniProtKB=Q9BPX5	Actin-related protein 2/3 complex subunit 5-like protein	TAS	12473693	PubMed	PTHR12644:SF2	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5-LIKE PROTEIN
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	HUMAN|HGNC=1952|UniProtKB=P20309	Muscarinic acetylcholine receptor M3	TAS	12181435	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	RCA	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IGI	9514948	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	HUMAN|HGNC=10934|UniProtKB=P54219	Chromaffin granule amine transporter	ISS	12135927	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MACMU|Ensembl=ENSMMUG00000000893|UniProtKB=F6T7D0	Histone acetyltransferase p300	ISS	8413673	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00012	Cadherin signaling pathway	P00470	F-actin	MACMU|Ensembl=ENSMMUG00000012054|UniProtKB=F6TII3	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00053	T cell activation	P01312	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00018	EGF receptor signaling pathway	P00561	STAT	CANLF|Ensembl=ENSCAFG00000015213|UniProtKB=E2RB82	Signal transducer and activator of transcription	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00012	Cadherin signaling pathway	P00475	Frizzled	PANTR|Ensembl=ENSPTRG00000020122|UniProtKB=H2QVZ0	Uncharacterized protein	ISS	12549854	PubMed	PTHR11309:SF22	FRIZZLED-3
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	10693759	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00729	Goalpha	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	IDA	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00477	GSK3beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00053	T cell activation	P01320	PLC-gamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01425	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	HUMAN|HGNC=10430|UniProtKB=Q15418	Ribosomal protein S6 kinase alpha-1	ISS	15226426	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00049	Parkinson disease	P01213	Cyclin E	MACMU|Ensembl=ENSMMUG00000020668|UniProtKB=F7BEI4	Uncharacterized protein	ISS	12729791	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P02741	Flavin biosynthesis	P02936	FAD synthetase	DROME|FlyBase=FBgn0030431|UniProtKB=Q9VYI5	CG4407, isoform A	RCA			PTHR23293:SF9	FAD SYNTHASE
P00018	EGF receptor signaling pathway	P00562	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00048	PI3 kinase pathway	P01188	Gbetagamma	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	IC	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=98328|UniProtKB=P30875	Somatostatin receptor type 2	ISS	12181435	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P00057	Wnt signaling pathway	P01456	beta-arrestin	PANTR|Ensembl=ENSPTRG00000013052|UniProtKB=H2QJM8	Uncharacterized protein	ISS	11742073	PubMed	PTHR11792:SF15	S-ARRESTIN
P00059	p53 pathway	P04609	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	ISS	8700226	PubMed	PTHR10048:SF14	PI-3 KINASE
P00006	Apoptosis signaling pathway	P00302	ATF	MOUSE|MGI=MGI=1298366|UniProtKB=P81269	Cyclic AMP-dependent transcription factor ATF-1	ISS	11390664	PubMed	PTHR22952:SF258	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	PANTR|Ensembl=ENSPTRG00000007461|UniProtKB=H2QA34	Furin (Paired basic amino acid cleaving enzyme)	ISS	11861638	PubMed	PTHR42884:SF1	FURIN
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04570	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01098	CHT1	HUMAN|HGNC=28689|UniProtKB=Q8N4M1	Choline transporter-like protein 3	IC			PTHR12385:SF13	CHOLINE TRANSPORTER-LIKE PROTEIN 3
P00021	FGF signaling pathway	P00623	FGF	MOUSE|MGI=MGI=99604|UniProtKB=P37237	Fibroblast growth factor 8	ISS			PTHR11486:SF3	FIBROBLAST GROWTH FACTOR 8
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	IDA	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00029	Huntington disease	P00807	Actin	TAKRU|Ensembl=ENSTRUG00000007989|UniProtKB=P68140	Actin, alpha skeletal muscle A	IDA	11889139	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	PANTR|Ensembl=ENSPTRG00000003795|UniProtKB=H2Q3X5	Muscarinic acetylcholine receptor	ISS	12915051	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	IDA	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00059	p53 pathway	P01484	Chk2	HUMAN|HGNC=16627|UniProtKB=O96017	Serine/threonine-protein kinase Chk2	IGI	12356735	PubMed	PTHR44167:SF1	SERINE/THREONINE-PROTEIN KINASE CHK2
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	XENTR|Xenbase=XB-GENE-491459|UniProtKB=L7N3Q3	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02772	Pyruvate metabolism	P03132	Pyruvate Kinase	SYNY3|EnsemblGenome=BAA17574|UniProtKB=P73534	Pyruvate kinase 2	ISS	8905231	PubMed	PTHR11817:SF3	AT14039P-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01389	TTF2	HUMAN|HGNC=30779|UniProtKB=Q49AM1	Transcription termination factor 2, mitochondrial	ISS	604718	OMIM	PTHR15437:SF1	TRANSCRIPTION TERMINATION FACTOR 2, MITOCHONDRIAL
P02775	Salvage pyrimidine ribonucleotides	P03150	Uridine kinase	MOUSE|MGI=MGI=98904|UniProtKB=P52623	Uridine-cytidine kinase 1	ISS			PTHR10285:SF66	URIDINE-CYTIDINE KINASE 1
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	IDA	11707292	PubMed	PTHR24055:SF330	SUBFAMILY NOT NAMED
P02788	Xanthine and guanine salvage pathway	P03247	Xanthine phosphoribosyl transferase	BACTN|EnsemblGenome=BT_4386|UniProtKB=Q89ZJ1	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00057	Wnt signaling pathway	P01435	SWI/SNF	MOUSE|MGI=MGI=106209|UniProtKB=Q60848	Lymphocyte-specific helicase	IDA	11532957	PubMed	PTHR10799:SF812	LYMPHOID-SPECIFIC HELICASE
P04393	Ras Pathway	P04567	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	97102671	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00637	MKK4,7	MOUSE|MGI=MGI=1346869|UniProtKB=P47809	Dual specificity mitogen-activated protein kinase kinase 4	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00034	Integrin signalling pathway	P00913	Csk	HUMAN|HGNC=2444|UniProtKB=P41240	Tyrosine-protein kinase CSK	IDA	7687537	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00015	Circadian clock system	G01499	per	RAT|RGD=727863|UniProtKB=Q8CHI5	Period circadian protein homolog 1	ISS	20570170	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P00003	Alzheimer disease-amyloid secretase pathway	P00081	Pro-BACE-1	MACMU|Ensembl=ENSMMUG00000007785|UniProtKB=F7CQI1	Beta-secretase 1 isoform A preproprotein	ISS	10531052	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P02741	Flavin biosynthesis	P02937	3,4-Dihydroxy-2-butanone-4-phosphate synthase	NEUCR|EnsemblGenome=EFNCRG00000001469|UniProtKB=Q7S213	3,4-dihydroxy-2-butanone 4-phosphate synthase	ISS			PTHR21327:SF18	3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE
P00020	FAS signaling pathway	P00615	JNK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00010	B cell activation	P00373	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	IC	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00047	PDGF signaling pathway	P01143	ERK	ORYSJ|Gene=Os01g0665200|UniProtKB=Q5SN53	Mitogen-activated protein kinase 8	ISS	12787066	PubMed	PTHR24055:SF219	SUBFAMILY NOT NAMED
P02743	Formyltetrahydroformate biosynthesis	P02953	Cobalamin dependent homocysteine transmethylase	FUSNN|EnsemblGenome=FN0163|UniProtKB=Q8RGW4	5-methyltetrahydrofolate--homocysteine methyltransferase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P00018	EGF receptor signaling pathway	P00560	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00020	FAS signaling pathway	P00593	Caspase9	PANTR|Ensembl=ENSPTRG00000000200|UniProtKB=H2PY35	Caspase	ISS	11440972	PubMed	PTHR10454:SF157	CASPASE-9
P00011	Blood coagulation	P00435	FVa	BOVIN|Gene=F5|UniProtKB=Q28107	Coagulation factor V	ISS	2493324	gi	PTHR45199:SF1	COAGULATION FACTOR V
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00807	Actin	ORYSJ|EnsemblGenome=OS05G0106600|UniProtKB=Q65XH8	Os05g0106600 protein	IDA	11889126	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P04393	Ras Pathway	P04548	ATF2	BOVIN|Ensembl=ENSBTAG00000002295|UniProtKB=F1N177	Uncharacterized protein	ISS	10207617	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00049	Parkinson disease	P01227	20S proteasome	TRYB2|Gene=Tb927.3.780|UniProtKB=D6XCY8	Proteasome alpha 7 subunit	ISS	12859888	PubMed	PTHR11599:SF10	PROTEASOME SUBUNIT ALPHA TYPE-3
P00048	PI3 kinase pathway	P01193	IRS	HUMAN|HGNC=6125|UniProtKB=P35568	Insulin receptor substrate 1	IGI	1311924	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00034	Integrin signalling pathway	P00947	Laminin	BOVIN|Ensembl=ENSBTAG00000010229|UniProtKB=F1MMT2	Uncharacterized protein	ISS	2538453	PubMed	PTHR10574:SF291	LAMININ SUBUNIT ALPHA-2
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	XENTR|Xenbase=XB-GENE-481480|UniProtKB=Q5XGI6	Casein kinase 1, epsilon	ISS	11865049	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00008	Axon guidance mediated by Slit/Robo	P00355	Rho	DAPPU|EnsemblGenome=DAPPUDRAFT_301996|UniProtKB=E9HL06	Putative uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00005	Angiogenesis	P00223	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00591	PLCbeta	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P02752	Mannose metabolism	P03017	Mannose 6-P isomerase	PANTR|Gene=MPI|UniProtKB=A5A6K3	Mannose-6-phosphate isomerase	ISS	20563689	gi	PTHR10309:SF0	MANNOSE-6-PHOSPHATE ISOMERASE
P00057	Wnt signaling pathway	P01448	CBP	ARATH|TAIR=AT3G12980|UniProtKB=Q9LE42	Histone acetyltransferase HAC5	IDA	10823891	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	BOVIN|Ensembl=ENSBTAG00000011723|UniProtKB=E1BKL6	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00049	Parkinson disease	P01237	Complex I	MOUSE|MGI=MGI=1920150|UniProtKB=Q9D6J6	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	ISS	3100899	PubMed	PTHR10371:SF3	NADH DEHYDROGENASE  UBIQUINONE  FLAVOPROTEIN 2, MITOCHONDRIAL
P00018	EGF receptor signaling pathway	P00552	Ras	CANAL|EnsemblGenome=CaO19.1760|UniProtKB=Q59XU5	Ras-like protein 1	IGI	10515923	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00048	PI3 kinase pathway	P01202	p85	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00010	B cell activation	P00376	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00019	Endothelin signaling pathway	P00586	Gq	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P04393	Ras Pathway	P04570	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00238	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00004	Alzheimer disease-presenilin pathway	P00114	actin	RAT|RGD=628837|UniProtKB=P60711	Actin, cytoplasmic 1	IDA	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CANLF|Ensembl=ENSCAFG00000015708|UniProtKB=F2Z4N0	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	LEIMA|EnsemblGenome=LmjF.35.3960|UniProtKB=E9AFM1	Protein kinase A catalytic subunit isoform 2	IC	10218114	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00558	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IGI	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05917	Opioid proopiomelanocortin pathway	P06004	Mu or Delta receptor	MONDO|Ensembl=ENSMODG00000008382|UniProtKB=F7CDR6	Uncharacterized protein (Fragment)	ISS	11259498	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00010	B cell activation	P00383	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DICPU|Gene=DICPUDRAFT_90232|UniProtKB=F1A175	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00037	Ionotropic glutamate receptor pathway	P01012	PICK	CANLF|Ensembl=ENSCAFG00000001431|UniProtKB=E2RPE0	Uncharacterized protein	ISS	12941441	PubMed	PTHR12141:SF1	PRKCA-BINDING PROTEIN
P00057	Wnt signaling pathway	P01435	SWI/SNF	MOUSE|MGI=MGI=1935127|UniProtKB=Q6PGB8	Probable global transcription activator SNF2L1	ISS	11532957	PubMed	PTHR10799:SF819	GLOBAL TRANSCRIPTION ACTIVATOR SNF2L1-RELATED
P05913	Enkephalin release	P05972	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00015	Circadian clock system	P00502	Casein kinase I	CHICK|Ensembl=ENSGALG00000002719|UniProtKB=E1BVW0	Uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00052	TGF-beta signaling pathway	P01275	P38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00628	JNK1-3	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	MACMU|Ensembl=ENSMMUG00000014627|UniProtKB=F7GNE4	Catenin beta-1	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P00006	Apoptosis signaling pathway	P00310	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P04609	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00022	General transcription by RNA polymerase I	P00651	TAF-IA	PANTR|Ensembl=ENSPTRG00000002007|UniProtKB=H2Q165	TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa	ISS	10894955	PubMed	PTHR32122:SF1	TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT A
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00641	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00005	Angiogenesis	P00224	PDGF	MOUSE|MGI=MGI=1859631|UniProtKB=Q8CI19	Platelet-derived growth factor C	ISS			PTHR11633:SF5	PLATELET-DERIVED GROWTH FACTOR C
P00036	Interleukin signaling pathway	P00996	STAT	CANLF|Ensembl=ENSCAFG00000000163|UniProtKB=F1PAY3	Signal transducer and activator of transcription	ISS	94367369	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00019	Endothelin signaling pathway	P00566	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00310	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	IDA	10799299	PubMed	PTHR10048:SF14	PI-3 KINASE
P00018	EGF receptor signaling pathway	P00539	14-3-3	ENTHI|EnsemblGenome=EHI_098280|UniProtKB=C4LXB1	14-3-3 protein 2	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P04393	Ras Pathway	P04542	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01300	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00623	FGF	RAT|RGD=2605|UniProtKB=P61149	Fibroblast growth factor 1	ISS	12095987	PubMed	PTHR11486:SF86	FIBROBLAST GROWTH FACTOR 1
P00059	p53 pathway	P01486	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	TAS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IPI	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	CAEBR|Gene=CBG_05938|UniProtKB=H8WGV2	Protein CBR-ITR-1, isoform a	ISS	11007872	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	IC	96149441	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	SCHPO|PomBase=SPCC736.08|UniProtKB=O74954	Transcription factor cbf11	NAS			PTHR10665:SF0	SUPPRESSOR OF HAIRLESS PROTEIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04570	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00646	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	IPI	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05913	Enkephalin release	P05977	G-Protein (s)	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00019	Endothelin signaling pathway	P00589	Akt	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	IGI	9716402	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	TAS	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	PANTR|Ensembl=ENSPTRG00000001108|UniProtKB=H2PZP0	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	CANLF|Ensembl=ENSCAFG00000002617|UniProtKB=E2QUL1	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	XENTR|Xenbase=XB-GENE-494200|UniProtKB=F7CS79	Uncharacterized protein	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00845	Cyclooxygenase	MOUSE|MGI=MGI=97798|UniProtKB=Q05769	Prostaglandin G/H synthase 2	IDA	97122334	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	XENTR|Ensembl=ENSXETG00000021375|UniProtKB=F6T423	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IGI	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Ensembl=ENSPTRG00000000543|UniProtKB=H2PYN8	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P05730	Endogenous cannabinoid signaling	P05746	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	RAT|RGD=71031|UniProtKB=Q06486	Casein kinase I isoform delta	IDA	10617630	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00045	Notch signaling pathway	P01108	Nicastrin	ARATH|TAIR=AT3G52640|UniProtKB=Q8GUM5	Nicastrin	TAS	10993067	PubMed	PTHR21092:SF0	NICASTRIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONBE|Gene=37852|UniProtKB=A9V489	Predicted protein	IC	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00019	Endothelin signaling pathway	P00570	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01438	PP2A	DANRE|ZFIN=ZDB-GENE-030904-6|UniProtKB=Q7ZUQ2	Ppp2r5e1 protein	ISS	11007767	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	HUMAN|HGNC=2453|UniProtKB=P49674	Casein kinase I isoform epsilon	IDA	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00048	PI3 kinase pathway	P01196	PDK1	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	IGI	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00049	Parkinson disease	P01238	14-3-3	CANLF|Ensembl=ENSCAFG00000009514|UniProtKB=F1PKW7	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P04397	p53 pathway by glucose deprivation	P04645	TSC1	MACMU|Ensembl=ENSMMUG00000009918|UniProtKB=F6Y6G0	Hamartin isoform 1	ISS	12820960	PubMed	PTHR15154:SF2	HAMARTIN
P00054	Toll receptor signaling pathway	P01346	TLR	HUMAN|HGNC=11850|UniProtKB=O00206	Toll-like receptor 4	ISS			PTHR44568:SF1	TOLL-LIKE RECEPTOR 4
P00056	VEGF signaling pathway	P01414	PLC-gamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05915	Opioid proenkephalin pathway	P05991	Enkephalin	DANRE|ZFIN=ZDB-GENE-030729-31|UniProtKB=A8E7S2	Uncharacterized protein	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00057	Wnt signaling pathway	P01431	LRP5/6	CHICK|Ensembl=ENSGALG00000011558|UniProtKB=F1NWV6	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00049	Parkinson disease	P01240	hSel10	MONDO|Ensembl=ENSMODG00000006464|UniProtKB=F7FGS3	Uncharacterized protein	ISS			PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	BOVIN|Ensembl=ENSBTAG00000005903|UniProtKB=F1N1K8	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00057	Wnt signaling pathway	P01444	Wnt	BOVIN|Ensembl=ENSBTAG00000012914|UniProtKB=F1MHG3	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	TAS	7876156	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	G04694	p110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01446	Calcineurin	MOUSE|MGI=MGI=107164|UniProtKB=P63328	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	ISS	7532676	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00782	alpha-Adaptin	ARATH|TAIR=AT5G22770|UniProtKB=Q8LPL6	AP-2 complex subunit alpha-1	IDA	11532990	PubMed	PTHR22780:SF4	AP-2 COMPLEX SUBUNIT ALPHA-2
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00005	Angiogenesis	P00183	Shc	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	IDA	8264585	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00015	Circadian clock system	G01497	cry	MOUSE|MGI=MGI=1270841|UniProtKB=P97784	Cryptochrome-1	IDA	10217146	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CHICK|Ensembl=ENSGALG00000009844|UniProtKB=P68034	Actin, alpha cardiac muscle 1	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00030	Hypoxia response via HIF activation	P00819	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00922	Collagen	MOUSE|MGI=MGI=88447|UniProtKB=Q64739	Collagen alpha-2(XI) chain	IDA	10778855	PubMed	PTHR24023:SF509	COLLAGEN ALPHA-2 XI  CHAIN
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IGI	176910	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	RAT|RGD=3381|UniProtKB=P62716	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	BRAFL|Gene=BRAFLDRAFT_219190|UniProtKB=C3Z434	Serine/threonine-protein phosphatase (Fragment)	ISS	8392016	PubMed	PTHR11668:SF402	SERINE/THREONINE-PROTEIN PHOSPHATASE
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	XENTR|Xenbase=XB-GENE-977853|UniProtKB=F7EBE7	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P05731	GABA-B receptor II signaling	P05754	Ggamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00012	Cadherin signaling pathway	P00465	TCF/LEF	RAT|RGD=620241|UniProtKB=Q9QXN1	Lymphoid enhancer-binding factor 1	ISS	9039917	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00024	Glycolysis	P00678	Enolase	RAT|RGD=2553|UniProtKB=P04764	Alpha-enolase	ISS	89079778	PubMed	PTHR11902:SF12	ALPHA-ENOLASE
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	BOVIN|Ensembl=ENSBTAG00000009778|UniProtKB=E1BMX0	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P04392	P53 pathway feedback loops 1	P04539	p53	CANLF|Ensembl=ENSCAFG00000013961|UniProtKB=F1PL57	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00045	Notch signaling pathway	P01103	Next	CANLF|Ensembl=ENSCAFG00000005627|UniProtKB=E2QUR0	Delta-like protein	ISS	12826675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00036	Interleukin signaling pathway	P00982	p27KIP1	PANTR|Ensembl=ENSPTRG00000004707|UniProtKB=H2Q5H2	Cyclin-dependent kinase inhibitor 1B (P27, Kip1)	ISS			PTHR10265:SF9	CYCLIN-DEPENDENT KINASE INHIBITOR 1B
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	IC	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00029	Huntington disease	P00810	GAPDH	PHYPA|Gene=PHYPADRAFT_109421|UniProtKB=A9RDK9	Glyceraldehyde-3-phosphate dehydrogenase	IPI			PTHR10836:SF76	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE A
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00036	Interleukin signaling pathway	P00973	PKB	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	CHICK|Ensembl=ENSGALG00000014539|UniProtKB=F1N861	Uncharacterized protein	ISS	1321498	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CHICK|Ensembl=ENSGALG00000015434|UniProtKB=F1NU20	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	10875333	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	CANLF|Ensembl=ENSCAFG00000017575|UniProtKB=Q076A5	Myosin-4	ISS	89264452	PubMed	PTHR13140:SF657	MYOSIN-4
P00057	Wnt signaling pathway	P01440	Cadherin	BOVIN|Ensembl=ENSBTAG00000015058|UniProtKB=F1MW29	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF81	CADHERIN-4
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00186	FGFR-1	DANRE|ZFIN=ZDB-GENE-980526-255|UniProtKB=Q90Z00	Fibroblast growth factor receptor 1-A	ISS			PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P00059	p53 pathway	P04630	PP2A	SCHMA|EnsemblGenome=Smp_165490|UniProtKB=C1LZY9	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00006	Apoptosis signaling pathway	P00269	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	TAS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00018	EGF receptor signaling pathway	P00547	PP2A	ARATH|TAIR=AT1G13460|UniProtKB=Q8LF36	Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform	ISS			PTHR10257:SF46	SERINE/THREONINE PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B' DELTA ISOFORM-RELATED
P00005	Angiogenesis	P00237	FRP	XENTR|Xenbase=XB-GENE-482077|UniProtKB=F6ZIJ4	Uncharacterized protein (Fragment)	ISS	10960783	PubMed	PTHR11309:SF11	SIZZLED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000007882|UniProtKB=G3X7Z2	Uncharacterized protein	ISS	11976940	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	EMENI|EnsemblGenome=CADANIAG00007315|UniProtKB=P20359	Actin, gamma	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00010	B cell activation	P00384	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05915	Opioid proenkephalin pathway	P05994	G-protein	ORNAN|Ensembl=ENSOANG00000013961|UniProtKB=F6VPY1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00029	Huntington disease	P00800	PolyQ Htt	HUMAN|HGNC=4851|UniProtKB=P42858	Huntingtin	TAS	7620118	PubMed	PTHR10170:SF10	HUNTINGTIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01021	Vglut	BOVIN|Ensembl=ENSBTAG00000001088|UniProtKB=E1BA07	Uncharacterized protein	ISS	12815758	PubMed	PTHR11662:SF207	VESICULAR GLUTAMATE TRANSPORTER 3
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95811|UniProtKB=Q9Z2W8	Glutamate receptor 4	ISS	12497607	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00057	Wnt signaling pathway	P01451	Galpha	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00036	Interleukin signaling pathway	P00985	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00029	Huntington disease	G01531	BDNF	BOVIN|Ensembl=ENSBTAG00000008134|UniProtKB=Q95106	Brain-derived neurotrophic factor	ISS	11724916	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00015	Circadian clock system	G01501	cry	MONDO|Ensembl=ENSMODG00000001579|UniProtKB=F7BWW8	Uncharacterized protein	ISS	10428031	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00070	VAT2	MOUSE|MGI=MGI=106677|UniProtKB=Q8BRU6	Synaptic vesicular amine transporter	IC	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00036	Interleukin signaling pathway	P00965	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IC	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00046	Oxidative stress response	P01135	p38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	FUSNN|EnsemblGenome=FN0454|UniProtKB=Q8RG63	Aldehyde dehydrogenase B	ISS			PTHR43111:SF1	ALDEHYDE DEHYDROGENASE B
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05915	Opioid proenkephalin pathway	P05994	G-protein	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00029	Huntington disease	P00776	c-Jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	8837781	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02772	Pyruvate metabolism	P03137	Citrate Lyase	RAT|RGD=1304615|UniProtKB=Q5I0K3	Citrate lyase subunit beta-like protein, mitochondrial	ISS			PTHR11105:SF0	CITRATE LYASE SUBUNIT BETA-LIKE PROTEIN, MITOCHONDRIAL
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	MOUSE|MGI=MGI=99685|UniProtKB=E9Q401	Ryanodine receptor 2	ISS	15226293	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	MONDO|Ensembl=ENSMODG00000019001|UniProtKB=F7CP86	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00054	Toll receptor signaling pathway	P01346	TLR	HUMAN|HGNC=16711|UniProtKB=Q9Y2C9	Toll-like receptor 6	ISS			PTHR24365:SF422	TOLL-LIKE RECEPTOR 6
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Gene=DRD2|UniProtKB=P60026	D(2) dopamine receptor	ISS	2039532	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00540	MKK3,6	MOUSE|MGI=MGI=1346870|UniProtKB=P70236	Dual specificity mitogen-activated protein kinase kinase 6	ISS	8622669	PubMed	PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P00052	TGF-beta signaling pathway	P01292	RSmads	ANOGA|Gene=AgaP_AGAP008551|UniProtKB=Q7Q8L8	Mothers against decapentaplegic homolog	TAS	9395284	PubMed	PTHR13703:SF40	PROTEIN MOTHERS AGAINST DPP
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MOUSE|MGI=MGI=95774|UniProtKB=Q8CGK7	Guanine nucleotide-binding protein G(olf) subunit alpha	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P06664	Gonadotropin-releasing hormone receptor pathway	P06753	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	RCA	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00006	Apoptosis signaling pathway	P00274	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00219	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	DROME|FlyBase=FBgn0011225|UniProtKB=Q01989	Myosin heavy chain 95F	IC			PTHR13140:SF706	UNCONVENTIONAL MYOSIN-VI
P00021	FGF signaling pathway	P00628	JNK1-3	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00011	Blood coagulation	P00441	FXIIa	HUMAN|HGNC=3530|UniProtKB=P00748	Coagulation factor XII	ISS	4503629	gi	PTHR44246:SF3	COAGULATION FACTOR XII
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00005	Angiogenesis	P00223	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00189	Fzd	BOVIN|Ensembl=ENSBTAG00000035084|UniProtKB=F1MLG5	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF22	FRIZZLED-3
P00057	Wnt signaling pathway	P01435	SWI/SNF	CHLTR|EnsemblGenome=CT_708|UniProtKB=O84714	SWF/SNF family helicase	IDA	11532957	PubMed	PTHR10799:SF845	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A CONTAINING DEAD/H BOX 1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-1712|UniProtKB=Q6PBY0	Guanine nucleotide binding protein (G protein), beta 5	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04397	p53 pathway by glucose deprivation	P04641	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01137	MNK1/2	RAT|RGD=1559603|UniProtKB=Q4G050	MAP kinase-interacting serine/threonine-protein kinase 1	ISS	9155018	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P04393	Ras Pathway	P04572	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00013	Cell cycle	P00481	APC	RAT|RGD=1305546|UniProtKB=B2RYJ1	Anapc2 protein	ISS	7019327	gi	PTHR11932:SF5	ANAPHASE-PROMOTING COMPLEX SUBUNIT 2
P05730	Endogenous cannabinoid signaling	P05746	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	SCHPO|PomBase=SPAC458.05|UniProtKB=P50520	Phosphatidylinositol 3-kinase vps34	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00010	B cell activation	P00383	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00059	p53 pathway	P01486	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01333	cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P05730	Endogenous cannabinoid signaling	P05748	mGluR	HUMAN|HGNC=4593|UniProtKB=Q13255	Metabotropic glutamate receptor 1	ISS	8314195	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MACMU|Ensembl=ENSMMUG00000018272|UniProtKB=F7HEB8	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	HUMAN|HGNC=7881|UniProtKB=P46531	Neurogenic locus notch homolog protein 1	IDA	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P06959	CCKR signaling map	P07028	SHP-2	HUMAN|HGNC=9644|UniProtKB=Q06124	Tyrosine-protein phosphatase non-receptor type 11	RCA	10544187	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00018	EGF receptor signaling pathway	P00564	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00005	Angiogenesis	P00211	GSK3beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05918	p38 MAPK pathway	P06019	ATF1	BOVIN|Ensembl=ENSBTAG00000018131|UniProtKB=Q08DA8	Cyclic AMP-dependent transcription factor ATF-1	ISS	11390664	PubMed	PTHR22952:SF258	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-011128-10|UniProtKB=Q90WX5	Cone transducin alpha subunit	ISS	12488551	PubMed	PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	METAC|EnsemblGenome=MA_0278|UniProtKB=Q8TTZ7	TATA-box-binding protein 3	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00019	Endothelin signaling pathway	P00587	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	CHICK|Ensembl=ENSGALG00000008591|UniProtKB=E1BZF6	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00045	Notch signaling pathway	G01541	E(spl)-C genes	BOVIN|Ensembl=ENSBTAG00000002483|UniProtKB=A6H787	HES5 protein	ISS	14973298	PubMed	PTHR10985:SF104	TRANSCRIPTION FACTOR HES-5
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IDA	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P02748	Isoleucine biosynthesis	P02997	Acetolactate synthase	METJA|EnsemblGenome=MJ_0277|UniProtKB=Q57725	Probable acetolactate synthase large subunit	ISS			PTHR18968:SF13	ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ORNAN|Ensembl=ENSOANG00000007581|UniProtKB=F6QWB7	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	CANLF|Gene=HTR2C|UniProtKB=Q60F97	5-hydroxytryptamine receptor 2C	ISS	12181435	PubMed	PTHR24247:SF32	5-HYDROXYTRYPTAMINE RECEPTOR 2C
P02770	Pyridoxal phosphate salvage pathway	P03122	Pyridoxamine kinase	DEIRA|EnsemblGenome=DR_A0184|UniProtKB=Q9RYX0	Pyridoxal kinase PdxY	ISS	10567266	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	NEUCR|EnsemblGenome=EFNCRG00000003893|UniProtKB=P78711	Actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CANLF|Gene=GRIN1|UniProtKB=Q5R1P0	Glutamate receptor ionotropic, NMDA 1	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00029	Huntington disease	P00790	beta-Tubulin	MACMU|Ensembl=ENSMMUG00000030028|UniProtKB=F7H0X2	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P00052	TGF-beta signaling pathway	P01275	P38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	TAS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IDA	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00049	Parkinson disease	P01232	CASK	PANTR|Ensembl=ENSPTRG00000021812|UniProtKB=H2R4R8	Uncharacterized protein	ISS	11430913	PubMed	PTHR23122:SF40	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00010	B cell activation	P00388	PLC gamma2	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00925	MEK	ORNAN|Ensembl=ENSOANG00000007732|UniProtKB=F6PXH5	Uncharacterized protein (Fragment)	ISS	97059154	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	IXOSC|EnsemblGenome=ISCW003614|UniProtKB=B7PHY7	Cdc42 protein, putative	ISS			PTHR24072:SF192	CDC42 HOMOLOG
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	HUMAN|HGNC=7881|UniProtKB=P46531	Neurogenic locus notch homolog protein 1	IDA	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00203	Erk	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01189	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	TAS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CANLF|Ensembl=ENSCAFG00000002617|UniProtKB=E2QUL1	Uncharacterized protein	ISS	14698601	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P04393	Ras Pathway	P04544	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	8235613	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00016	Cytoskeletal regulation by Rho GTPase	P00520	Rho GAPs	CAEBR|Gene=CBG02886|UniProtKB=A8WTA3	Protein CBR-RGA-1	ISS			PTHR23176:SF0	RHO GTPASE-ACTIVATING PROTEIN 68F
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05961	DOPA decarb.	PANTR|Ensembl=ENSPTRG00000019189|UniProtKB=H2QUK8	Uncharacterized protein	ISS	107930	OMIM	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00049	Parkinson disease	P01238	14-3-3	BOVIN|Gene=YWHAB|UniProtKB=P68250	14-3-3 protein beta/alpha	IDA	91108808	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00029	Huntington disease	P00787	MAPKK4	PANTR|Ensembl=ENSPTRG00000008783|UniProtKB=H2QCA7	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P06587	Nicotine pharmacodynamics pathway	P06590	GNG	ORNAN|Ensembl=ENSOANG00000013961|UniProtKB=F6VPY1	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00029	Huntington disease	P00805	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00797	p53	BOVIN|Ensembl=ENSBTAG00000008916|UniProtKB=F1MX60	Uncharacterized protein	ISS			PTHR12195:SF1	CYTOPLASMIC FMR1-INTERACTING PROTEIN 2
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04623	CBP	ARATH|TAIR=AT3G12980|UniProtKB=Q9LE42	Histone acetyltransferase HAC5	IDA	10823891	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00034	Integrin signalling pathway	P00948	Rho	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	IGI	11360179	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00021	FGF signaling pathway	P00645	Rac	DICDI|dictyBase=DDB_G0268622|UniProtKB=P34145	Rho-related protein rac1B	ISS	8649368	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00644	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	IPI	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MONDO|Ensembl=ENSMODG00000009514|UniProtKB=F7EVK3	Uncharacterized protein	ISS	7875593	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00019	Endothelin signaling pathway	P00566	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=1920423|UniProtKB=Q8VHR0	Protocadherin 18	IDA	8120095	PubMed	PTHR24028:SF9	PROTOCADHERIN-18
P05730	Endogenous cannabinoid signaling	P05748	mGluR	PANTR|Ensembl=ENSPTRG00000018684|UniProtKB=C7G3M7	Glutamate receptor, metabotropic 1	ISS	12488551	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=12786|UniProtKB=O00755	Protein Wnt-7a	IDA	8717036	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00010	B cell activation	P00401	jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	STRPU|EnsemblGenome=SPU_007424|UniProtKB=W4XVG8	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF155	TUBULIN BETA-2 CHAIN
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	CANLF|Ensembl=ENSCAFG00000017045|UniProtKB=E2QRU4	Uncharacterized protein	ISS	10839363	PubMed	PTHR19957:SF106	SYNTAXIN-10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00729	Goalpha	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	IDA	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	ISS	91298951	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	CANLF|Ensembl=ENSCAFG00000016335|UniProtKB=J9NXY2	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF322	SUBFAMILY NOT NAMED
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	BOVIN|Gene=IMPDH1|UniProtKB=A0JNA3	Inosine-5'-monophosphate dehydrogenase 1	ISS			PTHR11911:SF74	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 1
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00035	Interferon-gamma signaling pathway	P00961	STAT1	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	TAS	14984365	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CAEEL|WormBase=WBGene00006454|UniProtKB=G5EEN8	AEX-4	IC			PTHR19305:SF10	AEX-4
P00013	Cell cycle	P00488	E2F	DROME|FlyBase=FBgn0011766|UniProtKB=Q27368	Transcription factor E2f1	ISS	20196006	PubMed	PTHR12081:SF52	TRANSCRIPTION FACTOR E2F2-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	CANLF|Ensembl=ENSCAFG00000000415|UniProtKB=E2R2K4	Uncharacterized protein	ISS	8576107	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MACMU|Ensembl=ENSMMUG00000019112|UniProtKB=F6T8S6	N-methyl D-aspartate receptor subtype 2B	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	BOVIN|Ensembl=ENSBTAG00000020485|UniProtKB=P17870	Beta-arrestin-1	IDA	9388255	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00018	EGF receptor signaling pathway	P00539	14-3-3	CANAL|CGD=CAL0000198341|UniProtKB=O42766	14-3-3 protein homolog	IGI	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00018	EGF receptor signaling pathway	P00546	GAP	RAT|RGD=1307566|UniProtKB=A0A0G2JTA7	Protein Rasal2	ISS	9877179	PubMed	PTHR10194:SF52	RAS GTPASE-ACTIVATING PROTEIN NGAP
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	PANTR|Ensembl=ENSPTRG00000004718|UniProtKB=H2Q5I0	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	DAPPU|EnsemblGenome=DAPPUDRAFT_304982|UniProtKB=E9GN25	Putative uncharacterized protein	ISS			PTHR10410:SF5	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 14
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CAEEL|WormBase=WBGene00000065|UniProtKB=P0DM42	Actin-3	ISS	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00021	FGF signaling pathway	P00642	MEK1-2	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00059	p53 pathway	P01483	Mdm2	MOUSE|MGI=MGI=107934|UniProtKB=O35618	Protein Mdm4	ISS			PTHR13844:SF20	PROTEIN MDM4
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00981	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00036	Interleukin signaling pathway	P00981	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IDA	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	CAEEL|WormBase=WBGene00001612|UniProtKB=P34299	Glutamate receptor 1	ISS	8804111	PubMed	PTHR18966:SF297	GLUTAMATE RECEPTOR 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	ISS	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01444	Wnt	RAT|RGD=621463|UniProtKB=G3V819	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00023	General transcription regulation	P00658	TBP-associated factors	DROME|FlyBase=FBgn0024909|UniProtKB=Q9VHY5	Transcription initiation factor TFIID subunit 7	ISS			PTHR12228:SF0	TAF7 RNA POLYMERASE II, TATA BOX BINDING PROTEIN  TBP -ASSOCIATED FACTOR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00717	Phosphorylase b	MOUSE|MGI=MGI=97830|UniProtKB=Q9WUB3	Glycogen phosphorylase, muscle form	IDA	4318782	PubMed	PTHR11468:SF13	GLYCOGEN PHOSPHORYLASE, MUSCLE FORM
P00029	Huntington disease	P00780	Microtubule	ORNAN|Ensembl=ENSOANG00000003049|UniProtKB=F7B0P2	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P04393	Ras Pathway	P04541	p90RSK	CANLF|Ensembl=ENSCAFG00000000828|UniProtKB=F6UWI0	Ribosomal protein S6 kinase	ISS	15526037	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	PANTR|Ensembl=ENSPTRG00000008689|UniProtKB=H2QC41	Uncharacterized protein	ISS	22213672	PubMed	PTHR18945:SF477	ACETYLCHOLINE RECEPTOR SUBUNIT BETA
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	IDA	10995439	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000018853|UniProtKB=F6XSK8	Uncharacterized protein	ISS	12441358	PubMed	PTHR24229:SF42	SOMATOSTATIN RECEPTOR TYPE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05730	Endogenous cannabinoid signaling	P05748	mGluR	MACMU|Ensembl=ENSMMUG00000016428|UniProtKB=F7GU00	Metabotropic glutamate receptor 1 isoform alpha	ISS	8314195	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00914	Filamin	CANLF|Ensembl=ENSCAFG00000019521|UniProtKB=F1PWW0	Uncharacterized protein	ISS	11911837	PubMed	PTHR43998:SF6	FILAMIN-A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT1G07880|UniProtKB=Q9LQQ9	Mitogen-activated protein kinase 13	ISS	10851062	PubMed	PTHR24055:SF185	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00036	Interleukin signaling pathway	P00968	Ikk	MOUSE|MGI=MGI=1338071|UniProtKB=O88351	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	MACMU|Ensembl=ENSMMUG00000010173|UniProtKB=F7AGU8	Presenilin	ISS	12736250	PubMed	PTHR10202:SF18	PRESENILIN-1
P04393	Ras Pathway	P04555	PDK	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	IDA	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	BOVIN|Ensembl=ENSBTAG00000019210|UniProtKB=F1MJV4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	HUMAN|HGNC=3025|UniProtKB=P21917	D(4) dopamine receptor	IDA	11248120	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00007	Axon guidance mediated by semaphorins	P00331	PAK	BOVIN|Ensembl=ENSBTAG00000010191|UniProtKB=Q08E52	Serine/threonine-protein kinase PAK 1	ISS	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00004	Alzheimer disease-presenilin pathway	P00110	Ire-1 N-terminal fragment	YEAST|SGD=S000001121|UniProtKB=P32361	Serine/threonine-protein kinase/endoribonuclease IRE1	IDA	10619423	PubMed	PTHR13954:SF6	INOSITOL-REQUIRING ENZYME-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P02736	Coenzyme A biosynthesis	P02884	Dephospho-CoA kinase	BOVIN|Ensembl=ENSBTAG00000006048|UniProtKB=Q3ZBS0	Dephospho-CoA kinase domain-containing protein	ISS			PTHR10695:SF35	DEPHOSPHO-COA KINASE DOMAIN-CONTAINING PROTEIN
P00053	T cell activation	P01336	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_126324|UniProtKB=C3XYC2	Putative uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00010	B cell activation	P00371	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00790	beta-Tubulin	PHYPA|Gene=PHYPADRAFT_223215|UniProtKB=Q6TYR8	Beta-tubulin 6	ISS	9454836	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00004	Alzheimer disease-presenilin pathway	P00128	Erb-B4	MOUSE|MGI=MGI=104771|UniProtKB=Q61527	Receptor tyrosine-protein kinase erbB-4	ISS	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00036	Interleukin signaling pathway	P00983	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00648	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00034	Integrin signalling pathway	P00916	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P04398	p53 pathway feedback loops 2	P04661	PI3K	CAEEL|WormBase=WBGene00006932|UniProtKB=Q9TXI7	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	21924698	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00044	Nicotinic acetylcholine receptor signaling pathway	P01095	beta	HUMAN|HGNC=1964|UniProtKB=P30926	Neuronal acetylcholine receptor subunit beta-4	ISS	11602335	PubMed	PTHR18945:SF385	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-4
P00005	Angiogenesis	P00206	Wnt	MONDO|Ensembl=ENSMODG00000001196|UniProtKB=F7GH85	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	BOVIN|Ensembl=ENSBTAG00000012687|UniProtKB=F1MV64	Tyrosine-protein kinase receptor	ISS	2983222	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00006	Apoptosis signaling pathway	P00297	NFkappaB	HUMAN|HGNC=7795|UniProtKB=Q00653	Nuclear factor NF-kappa-B p100 subunit	ISS	12574369	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00005	Angiogenesis	P00189	Fzd	HUMAN|HGNC=4043|UniProtKB=Q13467	Frizzled-5	ISS	11212302	PubMed	PTHR11309:SF126	FRIZZLED-5
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MOUSE|MGI=MGI=99674|UniProtKB=Q91WF3	Adenylate cyclase type 4	IGI	9870949	PubMed	PTHR11920:SF286	ADENYLATE CYCLASE TYPE 4
P00019	Endothelin signaling pathway	P00591	PLCbeta	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00705	Gsalpha	BOVIN|Ensembl=ENSBTAG00000002125|UniProtKB=F1N461	Uncharacterized protein	ISS	6309844	PubMed	PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	HUMAN|HGNC=26777|UniProtKB=Q3SY69	Mitochondrial 10-formyltetrahydrofolate dehydrogenase	IC			PTHR11699:SF131	MITOCHONDRIAL 10-FORMYLTETRAHYDROFOLATE DEHYDROGENASE
P00036	Interleukin signaling pathway	P00965	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05731	GABA-B receptor II signaling	P05752	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00056	VEGF signaling pathway	P01414	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00059	p53 pathway	P01480	PTEN	HUMAN|HGNC=12023|UniProtKB=P56180	Putative tyrosine-protein phosphatase TPTE	IGI			PTHR12305:SF32	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE TPTE2-RELATED
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00219	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	DROME|FlyBase=FBgn0032859|UniProtKB=Q9VIM5	Actin-related protein 2/3 complex subunit 2	ISS	12473693	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IDA	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00012	Cadherin signaling pathway	P00463	betacatenin	TAKRU|Ensembl=ENSTRUG00000003520|UniProtKB=H2S791	Uncharacterized protein	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00057	Wnt signaling pathway	P01452	NFAT	BOVIN|Ensembl=ENSBTAG00000004368|UniProtKB=F1MSU2	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	CANLF|Ensembl=ENSCAFG00000013324|UniProtKB=F1PCS0	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00029	Huntington disease	P00805	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	1718748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00570	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01238	14-3-3	CANLF|Ensembl=ENSCAFG00000000580|UniProtKB=F1PBL1	Uncharacterized protein	ISS	1499718	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	RCA	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00011	Blood coagulation	P00458	GP IIIa	MACMU|Ensembl=ENSMMUG00000003289|UniProtKB=F7FG54	Integrin beta	ISS	5805339	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	TAS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00034	Integrin signalling pathway	P00920	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00059	p53 pathway	P01486	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	TAS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00238	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P02785	Valine biosynthesis	P03216	Acetolactate synthase	MACMU|Ensembl=ENSMMUG00000007729|UniProtKB=F7C8Z1	Acetolactate synthase-like protein	ISS			PTHR18968:SF155	ACETOLACTATE SYNTHASE-LIKE PROTEIN
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00170	Aph-1	MACMU|Ensembl=ENSMMUG00000017856|UniProtKB=F7DK04	Uncharacterized protein	ISS	12763021	PubMed	PTHR12889:SF1	GAMMA-SECRETASE SUBUNIT APH-1B
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	DEIRA|EnsemblGenome=DR_A0154|UniProtKB=Q9RYZ9	Glucosamine--fructose-6-phosphate aminotransferase	ISS			PTHR10937:SF8	SUBFAMILY NOT NAMED
P00053	T cell activation	P01319	PAK	HUMAN|HGNC=8592|UniProtKB=O75914	Serine/threonine-protein kinase PAK 3	IDA	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	MACMU|Ensembl=ENSMMUG00000020597|UniProtKB=F7BZR0	Acetyl-coenzyme A synthetase	ISS			PTHR24095:SF110	ACETYL-COENZYME A SYNTHETASE 2-LIKE, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00020	FAS signaling pathway	P00597	Apaf1	HUMAN|HGNC=576|UniProtKB=O14727	Apoptotic protease-activating factor 1	ISS	14526190	PubMed	PTHR22845:SF5	APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IDA	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00036	Interleukin signaling pathway	P00990	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02738	De novo purine biosynthesis	P02907	dADP kinase	PANTR|Ensembl=ENSPTRG00000004326|UniProtKB=H2Q4V0	Uncharacterized protein	ISS			PTHR44107:SF3	DOWN SYNDROME CELL ADHESION MOLECULE-LIKE PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01001	KA4	MOUSE|MGI=MGI=95817|UniProtKB=Q8BMF5	Glutamate receptor ionotropic, kainate 4	ISS	12941441	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00057	Wnt signaling pathway	P01451	Galpha	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00552	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P02748	Isoleucine biosynthesis	P02994	Branched chain amino acid aminotransferase	PSEAE|EnsemblGenome=PA5013|UniProtKB=O86428	Branched-chain-amino-acid aminotransferase	ISS			PTHR42743:SF3	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE-LIKE PROTEIN 1-RELATED
P04397	p53 pathway by glucose deprivation	P04641	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00632	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00470	F-actin	XENTR|GeneID=394982|UniProtKB=P20399	Actin, alpha cardiac muscle 2	ISS	11889126	PubMed	PTHR11937:SF263	ACTIN
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00005	Angiogenesis	P00193	SOS-1	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00054	Toll receptor signaling pathway	P01367	MKK3	MOUSE|MGI=MGI=1346868|UniProtKB=O09110	Dual specificity mitogen-activated protein kinase kinase 3	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P05917	Opioid proopiomelanocortin pathway	P06009	K+ channel	RAT|RGD=621451|UniProtKB=Q9ES08	Potassium channel subfamily K member 9	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00010	B cell activation	P00375	Calmodulin	BOVIN|Ensembl=ENSBTAG00000001575|UniProtKB=F1N6C0	Uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF311	CALMODULIN
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00059	p53 pathway	P04609	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	ISS	96320556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	MACMU|Ensembl=ENSMMUG00000006702|UniProtKB=F7HJS7	Serine/threonine-protein kinase receptor	ISS	10683140	PubMed	PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00006	Apoptosis signaling pathway	P00269	MAPK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00833	RGS	MACMU|Ensembl=ENSMMUG00000001672|UniProtKB=F7G3M7	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF32	REGULATOR OF G-PROTEIN SIGNALING 13
P00019	Endothelin signaling pathway	P00570	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	NEUCR|EnsemblGenome=EFNCRG00000006013|UniProtKB=Q3Y3Z2	cAMP-dependent protein kinase type 3	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00048	PI3 kinase pathway	P01196	PDK1	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	IDA	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00006	Apoptosis signaling pathway	P00267	MADD	RAT|RGD=619922|UniProtKB=O08873	MAP kinase-activating death domain protein	ISS	9115275	PubMed	PTHR13008:SF7	MAP KINASE-ACTIVATING DEATH DOMAIN PROTEIN
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	10693759	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01199	Galpha	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00944	Actin	HUMAN|HGNC=17780|UniProtKB=Q562R1	Beta-actin-like protein 2	IPI	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	DROME|FlyBase=FBgn0052396|UniProtKB=Q9VRX3	Probable tubulin beta chain CG32396	ISS	9454836	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00006	Apoptosis signaling pathway	P00302	ATF	PANTR|Ensembl=ENSPTRG00000001596|UniProtKB=H2Q0H3	Uncharacterized protein	ISS	11390664	PubMed	PTHR22952:SF116	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-6 ALPHA
P04393	Ras Pathway	P04556	Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	IDA	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00060	Ubiquitin proteasome pathway	P01490	E3	MACMU|Ensembl=ENSMMUG00000009183|UniProtKB=F7HPB2	Uncharacterized protein	ISS	11252892	PubMed	PTHR11254:SF293	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P00056	VEGF signaling pathway	P01408	Akt/PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04616	PDK1/2	YEAST|SGD=S000005460|UniProtKB=Q12236	Serine/threonine-protein kinase PKH2	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MONDO|Ensembl=ENSMODG00000012546|UniProtKB=F6PM16	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IDA	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	DANRE|ZFIN=ZDB-GENE-030821-1|UniProtKB=Q8JH70	Fructose-bisphosphate aldolase C-B	ISS	2828145	gi	PTHR11627:SF3	FRUCTOSE-BISPHOSPHATE ALDOLASE C
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MACMU|Ensembl=ENSMMUG00000017683|UniProtKB=F6UA63	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00036	Interleukin signaling pathway	P00990	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000020010|UniProtKB=F7GJC2	Uncharacterized protein	ISS	8120095	PubMed	PTHR44603:SF2	CADHERIN-17
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00059	p53 pathway	P04623	CBP	ARATH|TAIR=AT1G67220|UniProtKB=Q9FYH1	Histone acetyltransferase HAC2	IDA	10664585	PubMed	PTHR13808:SF6	HISTONE ACETYLTRANSFERASE HAC2
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P02772	Pyruvate metabolism	P03139	Lactate Dehydrogenase	TRIVA|Gene=TVAG_171090|UniProtKB=A2FIP8	L-lactate dehydrogenase, putative	IDA	10339579	PubMed	PTHR23382:SF0	MALATE DEHYDROGENASE 2, MITOCHONDRIAL-RELATED
P00059	p53 pathway	P01486	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00044	Nicotinic acetylcholine receptor signaling pathway	P01095	beta	RAT|RGD=2351|UniProtKB=P12392	Neuronal acetylcholine receptor subunit beta-4	ISS	22213672	PubMed	PTHR18945:SF385	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-4
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	BRAFL|Gene=BRAFLDRAFT_123893|UniProtKB=C3XQF4	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00777	CBP	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00053	T cell activation	P01313	CD28	CHICK|Ensembl=ENSGALG00000008669|UniProtKB=P31043	T-cell-specific surface glycoprotein CD28 homolog	IGI	7534617	PubMed	PTHR11494:SF7	T-CELL-SPECIFIC SURFACE GLYCOPROTEIN CD28
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00049	Parkinson disease	P01211	ERK	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	IDA	10851062	PubMed	PTHR24055:SF330	SUBFAMILY NOT NAMED
P00059	p53 pathway	G04700	PAI	PANTR|Ensembl=ENSPTRG00000019519|UniProtKB=H2QV47	Uncharacterized protein	ISS	189578	gi	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00004	Alzheimer disease-presenilin pathway	P00123	CD44 C-terminal fragment	MACMU|Ensembl=ENSMMUG00000004327|UniProtKB=F6ZDZ8	Uncharacterized protein	ISS	12223485	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P00056	VEGF signaling pathway	P01407	Erk	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	12805548	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00057	Wnt signaling pathway	P01444	Wnt	DROME|FlyBase=FBgn0004360|UniProtKB=P28465	Protein Wnt-2	IDA	11266476	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00053	T cell activation	P01315	Calcineurin	HUMAN|HGNC=9315|UniProtKB=P16298	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	IGI	12015605	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01472	Histone deacetylase	RAT|RGD=1309799|UniProtKB=Q4QQW4	Histone deacetylase 1	ISS	10485845	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P05913	Enkephalin release	P05972	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00645	Rac	ENTHI|EnsemblGenome=EHI_181250|UniProtKB=C4M5Z7	Rho family GTPase	ISS	4757952	gi	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DANRE|ZFIN=ZDB-GENE-030131-1229|UniProtKB=Q6DHS1	Actin, alpha 2, smooth muscle, aorta	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	TAKRU|Ensembl=ENSTRUG00000015213|UniProtKB=H2UPJ1	Uncharacterized protein	ISS	20112749	PubMed	PTHR18966:SF356	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00057	Wnt signaling pathway	P01452	NFAT	PANTR|Ensembl=ENSPTRG00000008260|UniProtKB=H2QBD7	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	ISS	12787506	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00645	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	21244534	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00056	VEGF signaling pathway	P01417	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00922	Collagen	BOVIN|Ensembl=ENSBTAG00000019269|UniProtKB=F1MKG2	Uncharacterized protein	ISS	10778855	PubMed	PTHR44172:SF1	COLLAGEN ALPHA-2 VI  CHAIN
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	HUMAN|HGNC=4043|UniProtKB=Q13467	Frizzled-5	TAS	11212302	PubMed	PTHR11309:SF126	FRIZZLED-5
P00057	Wnt signaling pathway	P01456	beta-arrestin	MOUSE|MGI=MGI=99474|UniProtKB=Q91YI4	Beta-arrestin-2	IDA	4757780	gi	PTHR11792:SF20	BETA-ARRESTIN-2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01438	PP2A	IXOSC|EnsemblGenome=ISCW014549|UniProtKB=B7QGY5	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00046	Oxidative stress response	P01135	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	RAT|RGD=1307690|UniProtKB=D4A0I8	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (Predicted), isoform CRA_b	ISS	9462517	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	IDA	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00059	p53 pathway	P04633	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CANLF|Ensembl=ENSCAFG00000008756|UniProtKB=F2Z4N8	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MACMU|Ensembl=ENSMMUG00000007027|UniProtKB=F7F210	Alpha-cardiac actin	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	RAT|RGD=2734|UniProtKB=Q01812	Glutamate receptor ionotropic, kainate 4	ISS	12941441	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00052	TGF-beta signaling pathway	P01275	P38	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	TAS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00898	FKHR	HUMAN|HGNC=3821|UniProtKB=O43524	Forkhead box protein O3	ISS	10102273	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00049	Parkinson disease	P01235	Fyn kinase	MONDO|Ensembl=ENSMODG00000017905|UniProtKB=F7FG65	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00048	PI3 kinase pathway	P01194	S6K	RAT|RGD=620683|UniProtKB=P67999	Ribosomal protein S6 kinase beta-1	IDA	11861821	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P02761	Pantothenate biosynthesis	P03068	Pantoate-beta-alanine ligase	DEIRA|EnsemblGenome=DR_1164|UniProtKB=Q9RV66	Pantothenate synthetase	ISS			PTHR21299:SF1	PANTOATE--BETA-ALANINE LIGASE
P00011	Blood coagulation	P00415	Plasmin	BOVIN|Gene=PLG|UniProtKB=P06868	Plasminogen	ISS	2507247	gi	PTHR24261:SF5	PLASMINOGEN
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00049	Parkinson disease	P01230	Src kinase	RAT|RGD=621017|UniProtKB=Q07014	Tyrosine-protein kinase Lyn	IDA	11078745	PubMed	PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P00047	PDGF signaling pathway	P01152	RasGAP	CANLF|Ensembl=ENSCAFG00000007674|UniProtKB=E2QUM7	Uncharacterized protein	ISS	20475167	gi	PTHR10194:SF21	RAS GTPASE-ACTIVATING PROTEIN 2
P00054	Toll receptor signaling pathway	P01343	IRAK1	PANTR|Ensembl=ENSPTRG00000022423|UniProtKB=H2QZA3	Interleukin-1 receptor-associated kinase 1	ISS	96180673	PubMed	PTHR24419:SF1	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IDA	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P05913	Enkephalin release	P05972	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P06664	Gonadotropin-releasing hormone receptor pathway	P06844	SRC	MOUSE|MGI=MGI=98397|UniProtKB=P05480	Neuronal proto-oncogene tyrosine-protein kinase Src	RCA	8054685	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00060	Ubiquitin proteasome pathway	P01491	E2	MACMU|Ensembl=ENSMMUG00000016507|UniProtKB=F7G0V2	Ubiquitin-conjugating enzyme E2 S	ISS			PTHR44066:SF1	UBIQUITIN-CONJUGATING ENZYME E2 S
P00053	T cell activation	P01322	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	CAEBR|Gene=CBG01097|UniProtKB=A8WPJ8	Protein CBR-CMD-1	ISS	3885394	PubMed	PTHR23050:SF236	CALMODULIN
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00006	Apoptosis signaling pathway	P00303	c-Jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00060	Ubiquitin proteasome pathway	P01491	E2	SCHPO|PomBase=SPAC1250.03|UniProtKB=Q9UTN8	Ubiquitin-conjugating enzyme E2 14	ISS			PTHR24068:SF119	SUBFAMILY NOT NAMED
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00010	B cell activation	P00371	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04396	Vitamin D metabolism and pathway	P04605	P450 reductase	RAT|RGD=68335|UniProtKB=P00388	NADPH--cytochrome P450 reductase	TAS	2513880	PubMed	PTHR19384:SF17	NADPH--CYTOCHROME P450 REDUCTASE
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DICDI|dictyBase=DDB_G0279605|UniProtKB=P34148	Rho-related protein racB	ISS			PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P05913	Enkephalin release	P05978	AC	MOUSE|MGI=MGI=102891|UniProtKB=P51829	Adenylate cyclase type 7	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	ARATH|TAIR=AT4G13890|UniProtKB=Q9SVM4	Serine hydroxymethyltransferase 5	ISS			PTHR11680:SF28	SERINE HYDROXYMETHYLTRANSFERASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00019	Endothelin signaling pathway	P00589	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00021	FGF signaling pathway	P00642	MEK1-2	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IGI	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00107	kinesin	HUMAN|HGNC=21624|UniProtKB=Q9NSK0	Kinesin light chain 4	IDA	11740561	PubMed	PTHR19959:SF139	KINESIN LIGHT CHAIN 4
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	TAKRU|Ensembl=ENSTRUG00000008289|UniProtKB=H2T7U8	Uncharacterized protein	ISS	12928366	PubMed	PTHR24072:SF129	CDC42L PROTEIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	BOVIN|Ensembl=ENSBTAG00000018777|UniProtKB=E1BHU9	Uncharacterized protein	ISS	1409703	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P04393	Ras Pathway	P04570	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00965	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IC	9836512	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	ISS	91072385	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00048	PI3 kinase pathway	P01185	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05730	Endogenous cannabinoid signaling	P05746	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P02785	Valine biosynthesis	P03215	Branched chain amino acid aminotransferase	HUMAN|HGNC=977|UniProtKB=O15382	Branched-chain-amino-acid aminotransferase, mitochondrial	ISS			PTHR11825:SF39	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, MITOCHONDRIAL
P00024	Glycolysis	P00671	Phosphoglycerate kinase	BOVIN|Ensembl=ENSBTAG00000000894|UniProtKB=Q3T0P6	Phosphoglycerate kinase 1	ISS	79199779	PubMed	PTHR11406:SF14	PHOSPHOGLYCERATE KINASE 1
P00021	FGF signaling pathway	P00643	Raf-1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	G01533	Bax	HUMAN|HGNC=959|UniProtKB=Q07812	Apoptosis regulator BAX	ISS	14963330	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P05731	GABA-B receptor II signaling	P05755	Gbeta	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P06664	Gonadotropin-releasing hormone receptor pathway	P06786	ERK1/2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	RCA	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=95779|UniProtKB=P50149	Guanine nucleotide-binding protein G(t) subunit alpha-2	ISS	12488551	PubMed	PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CANLF|Ensembl=ENSCAFG00000018564|UniProtKB=E2RHU1	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P04398	p53 pathway feedback loops 2	P04669	ATM	YEAST|SGD=S000000184|UniProtKB=P38110	Serine/threonine-protein kinase TEL1	ISS			PTHR11139:SF72	SERINE-PROTEIN KINASE ATM
P00021	FGF signaling pathway	P00644	p38	DROME|FlyBase=FBgn0024846|UniProtKB=O61443	Mitogen-activated protein kinase 14B	ISS	11274345	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00049	Parkinson disease	P01236	Casein kinase II	ARATH|TAIR=AT4G17640|UniProtKB=P40229	Casein kinase II subunit beta'	IDA	10806215	PubMed	PTHR11740:SF15	CASEIN KINASE II SUBUNIT BETA-RELATED
P00029	Huntington disease	P00776	c-Jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00006	Apoptosis signaling pathway	P00302	ATF	BOVIN|Gene=CREB1|UniProtKB=P27925	Cyclic AMP-responsive element-binding protein 1	ISS	1354612	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00019	Endothelin signaling pathway	P00590	IP3 R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00067	MAO	BOVIN|Ensembl=ENSBTAG00000016206|UniProtKB=P21398	Amine oxidase [flavin-containing] A	ISS	90344230	PubMed	PTHR43563:SF3	AMINE OXIDASE  FLAVIN-CONTAINING  A
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00005	Angiogenesis	P00254	GTPase	MOUSE|MGI=MGI=106028|UniProtKB=Q62159	Rho-related GTP-binding protein RhoC	ISS	12090470	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00029	Huntington disease	P00787	MAPKK4	CANLF|Ensembl=ENSCAFG00000017851|UniProtKB=F1PBB6	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	RAT|RGD=2735|UniProtKB=Q63273	Glutamate receptor ionotropic, kainate 5	ISS	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00021	FGF signaling pathway	P00632	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P06959	CCKR signaling map	P07192	EGR1	HUMAN|HGNC=3238|UniProtKB=P18146	Early growth response protein 1	RCA	15611055	PubMed	PTHR44685:SF1	EARLY GROWTH RESPONSE PROTEIN 1
P00053	T cell activation	P01332	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00471	Cadherin	CANLF|Ensembl=ENSCAFG00000004836|UniProtKB=E2RM28	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF46	PROTOCADHERIN-8
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04393	Ras Pathway	P04547	Ras	BOVIN|Ensembl=ENSBTAG00000009778|UniProtKB=E1BMX0	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00010	B cell activation	P00384	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	HUMAN|HGNC=1952|UniProtKB=P20309	Muscarinic acetylcholine receptor M3	ISS	11166329	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00021	FGF signaling pathway	P00631	Grb2	DROME|FlyBase=FBgn0004638|UniProtKB=Q08012	Protein enhancer of sevenless 2B	ISS	4504111	gi	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00050	Plasminogen activating cascade	P01257	tPA	MACMU|Ensembl=ENSMMUG00000014432|UniProtKB=F7BHV7	Tissue-type plasminogen activator	ISS	4505861	gi	PTHR44617:SF1	TISSUE-TYPE PLASMINOGEN ACTIVATOR
P00053	T cell activation	P01320	PLC-gamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00021	FGF signaling pathway	P00627	ERK1-2	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00931	Integrin beta	MOUSE|MGI=MGI=96612|UniProtKB=O54890	Integrin beta-3	IDA	484963	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00006	Apoptosis signaling pathway	P00269	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	RAT|RGD=1312011|UniProtKB=Q6TXG7	Serine hydroxymethyltransferase	ISS			PTHR11680:SF21	SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	STRPU|EnsemblGenome=SPU_025182|UniProtKB=W4ZAK5	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00060	Ubiquitin proteasome pathway	P01491	E2	XENTR|Xenbase=XB-GENE-962537|UniProtKB=F6VCY8	Uncharacterized protein	ISS			PTHR24068:SF24	UBIQUITIN-CONJUGATING ENZYME E2 D4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	14505573	PubMed	PTHR10048:SF14	PI-3 KINASE
P00046	Oxidative stress response	P01129	JNK1/2	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00045	Notch signaling pathway	P01108	Nicastrin	MOUSE|MGI=MGI=1891700|UniProtKB=P57716	Nicastrin	TAS	10993067	PubMed	PTHR21092:SF0	NICASTRIN
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	CANLF|Ensembl=ENSCAFG00000010107|UniProtKB=E2RA74	Serine/threonine-protein kinase receptor	ISS	10683140	PubMed	PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	DANRE|ZFIN=ZDB-GENE-020503-1|UniProtKB=Q1LWJ4	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF498	TYROSINE-PROTEIN KINASE RECEPTOR
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	DANRE|ZFIN=ZDB-GENE-040426-877|UniProtKB=F1Q6Z7	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=8155|UniProtKB=P41146	Nociceptin receptor	IDA	11259498	PubMed	PTHR24229:SF11	NOCICEPTIN RECEPTOR
P05918	p38 MAPK pathway	P06033	TAB2	PANTR|Ensembl=ENSPTRG00000018690|UniProtKB=H2QTW1	TGF-beta activated kinase 1/MAP3K7 binding protein 2	ISS			PTHR10351:SF27	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 2
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_94959|UniProtKB=C3XYC4	Putative uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	ISS	9836510	gi	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00053	T cell activation	P01312	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IDA	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00046	Oxidative stress response	P01135	p38	DROME|FlyBase=FBgn0015765|UniProtKB=O62618	Mitogen-activated protein kinase 14A	TAS	10514528	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00182	p38MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00059	p53 pathway	G04696	Siah	MOUSE|MGI=MGI=108063|UniProtKB=Q06985	E3 ubiquitin-protein ligase SIAH1B	IDA	14985507	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00021	FGF signaling pathway	P00640	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00381	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00572	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	18021322	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MOUSE|MGI=MGI=95774|UniProtKB=Q8CGK7	Guanine nucleotide-binding protein G(olf) subunit alpha	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01188	Gbetagamma	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00052	TGF-beta signaling pathway	P01284	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00021	FGF signaling pathway	P00629	PP2A	HUMAN|HGNC=9299|UniProtKB=P67775	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P02771	Pyrimidine Metabolism	P03129	Aminotransferase	BOVIN|Gene=ABAT|UniProtKB=Q9BGI0	4-aminobutyrate aminotransferase, mitochondrial	ISS	8133261	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P05917	Opioid proopiomelanocortin pathway	P06007	alpha-MSH	MONDO|Ensembl=ENSMODG00000015853|UniProtKB=Q95J84	Proopiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	CHICK|Ensembl=ENSGALG00000013731|UniProtKB=B2WUP2	Suppressor of cytokine signaling 6	ISS	12645661	PubMed	PTHR44562:SF1	SUPPRESSOR OF CYTOKINE SIGNALING 6
P00036	Interleukin signaling pathway	P00964	p90RSK	CHICK|Ensembl=ENSGALG00000000366|UniProtKB=P18652	Ribosomal protein S6 kinase 2 alpha	ISS	6755374	gi	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00805	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8663|UniProtKB=Q9Y5I3	Protocadherin alpha-1	IDA	8120095	PubMed	PTHR24028:SF92	PROTOCADHERIN ALPHA-1
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IDA	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	DROME|FlyBase=FBgn0024814|UniProtKB=Q9VWA1	Clathrin light chain	IDA	11889126	PubMed	PTHR10639:SF7	CLATHRIN LIGHT CHAIN
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IDA	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CHICK|Ensembl=ENSGALG00000017238|UniProtKB=F1NWG3	Uncharacterized protein	IDA	92317054	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	94280860	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00056	VEGF signaling pathway	P01413	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01145	c-fos	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00005	Angiogenesis	P00244	MAPKAPK2/3	MACMU|Ensembl=ENSMMUG00000023567|UniProtKB=F7HHY8	Uncharacterized protein	ISS	9628873	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	BOVIN|Ensembl=ENSBTAG00000011579|UniProtKB=F1N5C5	Muscarinic acetylcholine receptor	ISS	12181435	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	CHICK|Ensembl=ENSGALG00000007039|UniProtKB=F1NG99	Tyrosine-protein kinase receptor	ISS	249616	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00021	FGF signaling pathway	P00627	ERK1-2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9836512	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	G04694	p110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01230	Src kinase	MACMU|Ensembl=ENSMMUG00000019206|UniProtKB=F6QQC0	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF181	TYROSINE-PROTEIN KINASE BLK
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ARATH|TAIR=AT1G13060|UniProtKB=O23717	Proteasome subunit beta type-5-A	ISS			PTHR11599:SF63	PROTEASOME SUBUNIT BETA TYPE
P04398	p53 pathway feedback loops 2	P04651	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00004	Alzheimer disease-presenilin pathway	P00114	actin	HUMAN|HGNC=132|UniProtKB=P60709	Actin, cytoplasmic 1	IDA	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Ensembl=ENSPTRG00000013825|UniProtKB=H2RAK4	Uncharacterized protein	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DICDI|dictyBase=DDB_G0269234|UniProtKB=P07830	Major actin	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00025	Hedgehog signaling pathway	P00692	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P06587	Nicotine pharmacodynamics pathway	P06613	CHRNB2	MACMU|Ensembl=ENSMMUG00000016089|UniProtKB=F7GMZ4	Neuronal acetylcholine receptor subunit beta-2	ISS	22213672	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04665	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04397	p53 pathway by glucose deprivation	G04706	TSC2	PANTR|Ensembl=ENSPTRG00000031311|UniProtKB=H2R1U8	Uncharacterized protein	ISS	12150915	PubMed	PTHR10063:SF0	TUBERIN
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MACMU|Ensembl=ENSMMUG00000006915|UniProtKB=F7EZ32	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	HUMAN|HGNC=11540|UniProtKB=P49848	Transcription initiation factor TFIID subunit 6	ISS			PTHR10221:SF12	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6
P02776	Serine glycine biosynthesis	P03160	Phosphoglycerate dehydrogenase	BOVIN|Gene=PHGDH|UniProtKB=Q5EAD2	D-3-phosphoglycerate dehydrogenase	ISS			PTHR42938:SF5	D-3-PHOSPHOGLYCERATE DEHYDROGENASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	HUMAN|HGNC=7777|UniProtKB=Q12968	Nuclear factor of activated T-cells, cytoplasmic 3	ISS	12787506	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00019	Endothelin signaling pathway	P00589	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01332	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00168	E-cadherin intracellular fragment	XENTR|Xenbase=XB-GENE-482277|UniProtKB=F6QAX3	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P00056	VEGF signaling pathway	P01417	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05915	Opioid proenkephalin pathway	P05994	G-protein	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01082	AC	MOUSE|MGI=MGI=2660854|UniProtKB=Q8C0T9	Adenylate cyclase type 10	IC	11744988	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P00052	TGF-beta signaling pathway	P01275	P38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01465	Ggamma	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CANLF|Ensembl=ENSCAFG00000001738|UniProtKB=E2RDG9	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00004	Alzheimer disease-presenilin pathway	P00111	C99	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00056	VEGF signaling pathway	P01423	p38MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00005	Angiogenesis	P00193	SOS-1	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS			PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00041	Metabotropic glutamate receptor group I pathway	P01062	mGluR1	MOUSE|MGI=MGI=1351338|UniProtKB=P97772	Metabotropic glutamate receptor 1	ISS	7476890	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	RAT|RGD=2342|UniProtKB=P08482	Muscarinic acetylcholine receptor M1	ISS	12915051	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P05731	GABA-B receptor II signaling	P05755	Gbeta	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00005	Angiogenesis	P00200	Dsh	DROME|FlyBase=FBgn0000499|UniProtKB=P51140	Segment polarity protein dishevelled	ISS			PTHR10878:SF25	SEGMENT POLARITY PROTEIN DISHEVELLED
P00057	Wnt signaling pathway	P01455	Smad4	DROME|FlyBase=FBgn0011648|UniProtKB=P42003	Protein mothers against dpp	IDA	7768443	PubMed	PTHR13703:SF40	PROTEIN MOTHERS AGAINST DPP
P00012	Cadherin signaling pathway	P00470	F-actin	ORYSJ|Gene=Os01g0866100|UniProtKB=P0C540	Actin-7	IC	11889126	PubMed	PTHR11937:SF205	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MOUSE|MGI=MGI=1351341|UniProtKB=Q68EF4	Metabotropic glutamate receptor 4	ISS			PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00021	FGF signaling pathway	P00643	Raf-1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IGI	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00019	Endothelin signaling pathway	P00568	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	RAT|RGD=3563|UniProtKB=P49807	Regulator of G-protein signaling 11 (Fragment)	ISS	8756726	PubMed	PTHR10845:SF144	REGULATOR OF G-PROTEIN SIGNALING 11
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CANLF|Ensembl=ENSCAFG00000002617|UniProtKB=E2QUL1	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00024	Glycolysis	P00678	Enolase	MACMU|Ensembl=ENSMMUG00000009443|UniProtKB=F6X1V9	Gamma-enolase	ISS	5803011	gi	PTHR11902:SF10	GAMMA-ENOLASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	TAS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00575	furin	XENTR|Xenbase=XB-GENE-999035|UniProtKB=F7CEB1	Uncharacterized protein	ISS	1722329	PubMed	PTHR42884:SF1	FURIN
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P02746	Heme biosynthesis	P02975	Uroporphyrinogen decarboxylase	DANRE|ZFIN=ZDB-GENE-000208-18|UniProtKB=Q9PTS2	Uroporphyrinogen decarboxylase	ISS			PTHR21091:SF2	UROPORPHYRINOGEN DECARBOXYLASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	BOVIN|Gene=CACNB1|UniProtKB=Q9MZL7	Voltage-dependent L-type calcium channel subunit beta-1	ISS	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MACMU|Ensembl=ENSMMUG00000014807|UniProtKB=F6W548	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P06587	Nicotine pharmacodynamics pathway	P06608	DDC	PANTR|Ensembl=ENSPTRG00000019189|UniProtKB=H2QUK8	Uncharacterized protein	ISS	107930	OMIM	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ORYSJ|EnsemblGenome=OS12G0163700|UniProtKB=Q0IPW3	Os12g0163700 protein	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04395	Vasopressin synthesis	P04589	Signal Peptidase	MACMU|Ensembl=ENSMMUG00000004408|UniProtKB=F7GUB4	Signal peptidase complex catalytic subunit SEC11	ISS	2674115	PubMed	PTHR10806:SF12	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11C
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00046	Oxidative stress response	P01132	c-jun	CHICK|Gene=JUN|UniProtKB=P18870	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00057	Wnt signaling pathway	P01444	Wnt	PANTR|Ensembl=ENSPTRG00000017278|UniProtKB=H2QRJ8	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P00029	Huntington disease	P00807	Actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	IDA	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04566	Stat 1/3	RAT|RGD=3772|UniProtKB=P52631	Signal transducer and activator of transcription 3	IDA	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	MACMU|Gene=IL1A|UniProtKB=P48089	Interleukin-1 alpha	ISS	2989698	PubMed	PTHR45409:SF1	INTERLEUKIN-1 ALPHA
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00551	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IGI	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00643	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	RCA	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00919	Arf6	XENTR|Xenbase=XB-GENE-967358|UniProtKB=F6V4X2	Uncharacterized protein (Fragment)	ISS	12932731	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00046	Oxidative stress response	P01138	MKK4	PANTR|Ensembl=ENSPTRG00000008783|UniProtKB=H2QCA7	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00011	Blood coagulation	P00429	PN2	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	ISS	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	RAT|RGD=1309063|UniProtKB=Q1KQ07	Signal transducer and activator of transcription	ISS	14598258	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00048	PI3 kinase pathway	P01192	p110	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	SCHPO|PomBase=SPBC12C2.11|UniProtKB=Q09740	Probable glutamine--fructose-6-phosphate aminotransferase [isomerizing]	ISS			PTHR10937:SF0	GH12731P-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9062|UniProtKB=Q9BRC7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	12860966	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	PANTR|Ensembl=ENSPTRG00000020706|UniProtKB=H2QWX3	Uncharacterized protein	ISS	9288972	PubMed	PTHR11829:SF191	FORKHEAD BOX PROTEIN H1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05913	Enkephalin release	P05974	G-Protein (i)	BOVIN|Ensembl=ENSBTAG00000003043|UniProtKB=P63212	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	PANTR|Ensembl=ENSPTRG00000013189|UniProtKB=H2QJV1	Uncharacterized protein	ISS	9756087	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000006307|UniProtKB=H2SSM1	Uncharacterized protein	IC			PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00747	Rhodopsin	BOVIN|Ensembl=ENSBTAG00000001310|UniProtKB=P02699	Rhodopsin	IDA	1634520	PubMed	PTHR24240:SF15	RHODOPSIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00561	STAT	HUMAN|HGNC=11362|UniProtKB=P42224	Signal transducer and activator of transcription 1-alpha/beta	IGI	10207096	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00126	Fe65	PANTR|Ensembl=ENSPTRG00000003288|UniProtKB=H2Q320	Uncharacterized protein	ISS	15115822	PubMed	PTHR14058:SF5	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1
P00029	Huntington disease	P00807	Actin	DROME|FlyBase=FBgn0000045|UniProtKB=P02574	Actin, larval muscle	IDA	10974003	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00015	Circadian clock system	G01497	cry	CHICK|Gene=CRY1|UniProtKB=Q8QG61	Cryptochrome-1	ISS			PTHR11455:SF16	CRYPTOCHROME-1
P00034	Integrin signalling pathway	P00951	Jnk	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00036	Interleukin signaling pathway	P00981	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	TAS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00828	Galphai	RAT|RGD=2713|UniProtKB=P10824	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04657	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IDA	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00047	PDGF signaling pathway	P01169	Vav	DROME|FlyBase=FBgn0040068|UniProtKB=Q9NHV9	Protein vav	ISS			PTHR22826:SF136	PROTEIN VAV
P00019	Endothelin signaling pathway	P00568	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IGI	3755548	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00048	PI3 kinase pathway	P01193	IRS	PANTR|Ensembl=ENSPTRG00000012989|UniProtKB=H2QJJ4	Insulin receptor substrate 1	ISS	5031805	gi	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00029	Huntington disease	P00774	Dynein complex	ANOGA|EnsemblGenome=AGAP006887|UniProtKB=Q7QII4	AGAP006887-PA	IPI	9454836	PubMed	PTHR11886:SF2	DYNEIN LIGHT CHAIN 4, AXONEMAL
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00057	Wnt signaling pathway	P01451	Galpha	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	IDA	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00034	Integrin signalling pathway	P00922	Collagen	CHICK|Ensembl=ENSGALG00000002546|UniProtKB=F1NI79	Uncharacterized protein	IDA	10778855	PubMed	PTHR24023:SF387	COLLAGEN ALPHA-1 V  CHAIN
P00029	Huntington disease	P00807	Actin	RAT|RGD=1304556|UniProtKB=P63259	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00056	VEGF signaling pathway	P01407	Erk	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	11832947	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00047	PDGF signaling pathway	P01173	STAT	MOUSE|MGI=MGI=103039|UniProtKB=Q9WVL2	Signal transducer and activator of transcription 2	ISS	11786546	PubMed	PTHR11801:SF41	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 2
P00005	Angiogenesis	P00243	Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00005	Angiogenesis	P00203	Erk	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	PANTR|Ensembl=ENSPTRG00000018764|UniProtKB=H2QU01	Uncharacterized protein	ISS	11081635	PubMed	PTHR15071:SF17	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
P00048	PI3 kinase pathway	P01177	P110ACT	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	TAS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Ensembl=ENSCAFG00000009203|UniProtKB=F1PVZ1	Muscarinic acetylcholine receptor	ISS	11166329	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	TAKRU|Ensembl=ENSTRUG00000014318|UniProtKB=H2UI49	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00057	Wnt signaling pathway	P01428	Frizzled	DROME|FlyBase=FBgn0016797|UniProtKB=Q9VVX3	Frizzled-2	IDA	11212302	PubMed	PTHR11309:SF90	FRIZZLED-8
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01447	Dishevelled	PANTR|Gene=DVL1|UniProtKB=Q5IS48	Segment polarity protein dishevelled homolog DVL-1	ISS	12549854	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00053	T cell activation	P01337	B7	CANLF|Ensembl=ENSCAFG00000011751|UniProtKB=Q9TTF2	B7-2 protein	IDA	7694363	PubMed	PTHR25466:SF2	T-LYMPHOCYTE ACTIVATION ANTIGEN CD86
P00057	Wnt signaling pathway	P01465	Ggamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00018	EGF receptor signaling pathway	P00552	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	3035212	PubMed	PTHR24070:SF385	GTPASE HRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00846	JAK	MOUSE|MGI=MGI=96629|UniProtKB=Q62120	Tyrosine-protein kinase JAK2	IDA	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00019	Endothelin signaling pathway	P00566	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02749	Leucine biosynthesis	P03002	Isopropylmalate isomerase	MYCTU|EnsemblGenome=Rv2987c|UniProtKB=P9WK95	3-isopropylmalate dehydratase small subunit	ISS			PTHR43345:SF2	3-ISOPROPYLMALATE DEHYDRATASE SMALL SUBUNIT
P00019	Endothelin signaling pathway	P00568	PKC	DANRE|ZFIN=ZDB-GENE-041001-104|UniProtKB=Q5TZD4	Protein kinase C	ISS	11880265	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00034	Integrin signalling pathway	P00923	Arf1	CANLF|Ensembl=ENSCAFG00000010433|UniProtKB=E2RNQ7	Uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF294	ADP-RIBOSYLATION FACTOR 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04398	p53 pathway feedback loops 2	P04665	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00383	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06807	gnai	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	RCA	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P06959	CCKR signaling map	P07088	RYR1/2/3	HUMAN|HGNC=10484|UniProtKB=Q92736	Ryanodine receptor 2	RCA	11279177	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00005	Angiogenesis	P00251	cPLA2	DANRE|ZFIN=ZDB-GENE-990415-45|UniProtKB=P50392	Cytosolic phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02757	O-antigen biosynthesis	P03050	dTDP-4-dehydrorhamnose reductase	ORNAN|Ensembl=ENSOANG00000004634|UniProtKB=F7FVE2	Uncharacterized protein	ISS			PTHR10491:SF4	METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	CHICK|Ensembl=ENSGALG00000001476|UniProtKB=F1NSA8	Uncharacterized protein	ISS	10476970	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00005	Angiogenesis	P00235	c-Fos	BOVIN|Ensembl=ENSBTAG00000004322|UniProtKB=O77628	Proto-oncogene c-Fos	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P02752	Mannose metabolism	P03015	GDP-Mannose 4,6-dehydratase	ARATH|TAIR=AT3G51160|UniProtKB=P93031	GDP-mannose 4,6 dehydratase 2	TAS	15230418	gi	PTHR43715:SF1	GDP-MANNOSE 4,6 DEHYDRATASE
P00011	Blood coagulation	P00414	Thrombin	PANTR|Ensembl=ENSPTRG00000003552|UniProtKB=H2Q3I2	Prothrombin	ISS	4503635	gi	PTHR24254:SF10	PROTHROMBIN
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	IDA	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05915	Opioid proenkephalin pathway	P05994	G-protein	TAKRU|Ensembl=ENSTRUG00000016101|UniProtKB=H2UW32	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IGI	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	IGI	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00021	FGF signaling pathway	P00632	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MACMU|Ensembl=ENSMMUG00000000846|UniProtKB=F6Q1E0	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR15936:SF2	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-13
P02770	Pyridoxal phosphate salvage pathway	P03123	Pyridoxine-5-phosphate oxidase	MYCTU|EnsemblGenome=Rv2607|UniProtKB=P9WIJ1	Pyridoxine/pyridoxamine 5'-phosphate oxidase	ISS	9634230	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DICPU|Gene=DICPUDRAFT_90232|UniProtKB=F1A175	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02750	Lipoate_biosynthesis	P03004	Lipoate synthase	CAEEL|WormBase=WBGene00010809|UniProtKB=Q21452	Lipoyl synthase, mitochondrial	ISS			PTHR10949:SF0	LIPOYL SYNTHASE, MITOCHONDRIAL
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MONDO|Ensembl=ENSMODG00000025248|UniProtKB=F7F5X1	Uncharacterized protein	ISS	3023884	PubMed	PTHR24070:SF186	GTPASE KRAS
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00034	Integrin signalling pathway	P00925	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02778	Sulfate assimilation	P03167	Sulfate adenylyltransferase	MONDO|Ensembl=ENSMODG00000020610|UniProtKB=F6ZBF0	Uncharacterized protein	ISS			PTHR11055:SF17	BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE 1
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	HUMAN|HGNC=4573|UniProtKB=P42263	Glutamate receptor 3	IC	10331083	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P02765	Phenylalanine biosynthesis	P03099	Prephenate dehydratase	BACTN|EnsemblGenome=BT_3936|UniProtKB=Q8A0T5	Prephenate dehydratase	ISS			PTHR21022:SF0	PREPHENATE DEHYDRATASE-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00034	Integrin signalling pathway	P00920	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	PANTR|Ensembl=ENSPTRG00000008768|UniProtKB=H2QC98	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF368	MYOSIN-8
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	IC	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04393	Ras Pathway	P04558	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00049	Parkinson disease	P01233	Elk-1	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	11050086	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00029	Huntington disease	P00807	Actin	CAEBR|Gene=CBG18256|UniProtKB=A8XS95	Protein CBR-ACT-5	ISS	11889126	PubMed	PTHR11937:SF352	ACTIN
P00007	Axon guidance mediated by semaphorins	P00340	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00059	p53 pathway	P04609	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00790	beta-Tubulin	HUMAN|HGNC=16257|UniProtKB=Q9H4B7	Tubulin beta-1 chain	TAS	9454836	PubMed	PTHR11588:SF112	TUBULIN BETA-1 CHAIN
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CAEBR|Gene=CBG05896|UniProtKB=A8X1E0	Phosphoinositide phospholipase C	ISS			PTHR10336:SF147	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-2
P00057	Wnt signaling pathway	P01428	Frizzled	BOVIN|Ensembl=ENSBTAG00000020957|UniProtKB=F1MGM1	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF126	FRIZZLED-5
P00010	B cell activation	P00396	CD45	RAT|RGD=3451|UniProtKB=P04157	Receptor-type tyrosine-protein phosphatase C	IGI	1672451	PubMed	PTHR19134:SF284	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IGI	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00049	Parkinson disease	P01238	14-3-3	RAT|RGD=3978|UniProtKB=P68511	14-3-3 protein eta	ISS	14593000	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00057	Wnt signaling pathway	P01443	Phospholipase C	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04395	Vasopressin synthesis	P04589	Signal Peptidase	RAT|RGD=628665|UniProtKB=Q9WTR7	Signal peptidase complex catalytic subunit SEC11C	IC	2092035	PubMed	PTHR10806:SF12	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11C
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P02777	Succinate to proprionate conversion	P03163	Methylmalonyl-CoA decarboxylase	CANLF|Ensembl=ENSCAFG00000007170|UniProtKB=F1PTU4	Uncharacterized protein	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00053	T cell activation	P01332	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	BRAFL|Gene=BRAFLDRAFT_128184|UniProtKB=C4A0B6	Tyrosine-protein kinase receptor	ISS	11182407	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	PANTR|Ensembl=ENSPTRG00000006553|UniProtKB=A5A6H0	C-fos	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	HUMAN|HGNC=8592|UniProtKB=O75914	Serine/threonine-protein kinase PAK 3	ISS	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00021	FGF signaling pathway	P00628	JNK1-3	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00054	Toll receptor signaling pathway	P01352	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00021	FGF signaling pathway	P00629	PP2A	HUMAN|HGNC=9300|UniProtKB=P62714	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	IDA	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00274	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P06664	Gonadotropin-releasing hormone receptor pathway	G06676	GnRHR	MOUSE|MGI=MGI=95790|UniProtKB=Q01776	Gonadotropin-releasing hormone receptor	RCA	12629106	PubMed	PTHR24241:SF22	GONADOTROPIN-RELEASING HORMONE RECEPTOR
P04393	Ras Pathway	P04567	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00009	Axon guidance mediated by netrin	P00363	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	10799299	PubMed	PTHR10048:SF14	PI-3 KINASE
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8971|UniProtKB=O00443	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	METJA|EnsemblGenome=MJ_1377|UniProtKB=Q58772	Glutamate--tRNA ligase	ISS			PTHR43097:SF5	GLUTAMATE--TRNA LIGASE, CYTOPLASMIC
P00006	Apoptosis signaling pathway	P00319	TRADD	RAT|RGD=621313|UniProtKB=D3ZZC5	Protein Tradd	ISS			PTHR14913:SF0	TUMOR NECROSIS FACTOR RECEPTOR TYPE 1-ASSOCIATED DEATH DOMAIN PROTEIN
P00006	Apoptosis signaling pathway	P00269	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	20216076	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00025	Hedgehog signaling pathway	P00699	Su(fu)	MACMU|Ensembl=ENSMMUG00000004396|UniProtKB=F7FM83	Suppressor of fused homolog	ISS	10920228	PubMed	PTHR10928:SF2	SUPPRESSOR OF FUSED HOMOLOG
P00005	Angiogenesis	P00249	PAK	ORNAN|Ensembl=ENSOANG00000002406|UniProtKB=F7BAS2	Uncharacterized protein	ISS	7559398	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=11433|UniProtKB=Q16623	Syntaxin-1A	ISS	1321498	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	PANTR|Ensembl=ENSPTRG00000006553|UniProtKB=A5A6H0	C-fos	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P02751	Lysine biosynthesis	P03008	Dihydrodipicolinate synthase	PSEAE|EnsemblGenome=PA0223|UniProtKB=Q9I6R5	Probable dihydrodipicolinate synthetase	ISS			PTHR12128:SF15	4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL
P02775	Salvage pyrimidine ribonucleotides	P03149	Cytidine kinase	HUMAN|HGNC=14859|UniProtKB=Q9HA47	Uridine-cytidine kinase 1	ISS			PTHR10285:SF66	URIDINE-CYTIDINE KINASE 1
P00005	Angiogenesis	P00223	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01188	Gbetagamma	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00020	FAS signaling pathway	P00615	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00049	Parkinson disease	P01236	Casein kinase II	PHYPA|Gene=PHYPADRAFT_218940|UniProtKB=A9T4Y7	Predicted protein	ISS	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHICK|Ensembl=ENSGALG00000028749|UniProtKB=Q5ZMQ2	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	DROME|FlyBase=FBgn0001991|UniProtKB=Q24270	Voltage-dependent calcium channel type D subunit alpha-1	ISS	91056091	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00586	Gq	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00931	Integrin beta	CANLF|Ensembl=ENSCAFG00000003821|UniProtKB=E2RT60	Integrin beta	ISS	3487386	PubMed	PTHR10082:SF28	INTEGRIN BETA-1
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	ISS	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04651	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00030	Hypoxia response via HIF activation	P00819	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	XENTR|Xenbase=XB-GENE-490883|UniProtKB=Q6NVA9	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00018	EGF receptor signaling pathway	P00539	14-3-3	CHICK|Gene_ORFName=RCJMB04_1e8|UniProtKB=Q5ZMT0	14-3-3 protein epsilon	ISS	98119747	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00029	Huntington disease	P00796	Kainate receptor	MOUSE|MGI=MGI=95815|UniProtKB=P39087	Glutamate receptor ionotropic, kainate 2	IDA	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00057	Wnt signaling pathway	P01452	NFAT	RAT|RGD=1307690|UniProtKB=D4A0I8	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (Predicted), isoform CRA_b	ISS	9133421	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00054	Toll receptor signaling pathway	P01355	AP1	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	3136397	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	CAEBR|Gene=CBG08085|UniProtKB=A8X5S0	Protein CBR-ARR-1	ISS	11742073	PubMed	PTHR11792:SF17	KURTZ ARRESTIN
P05916	Opioid prodynorphin pathway	P06002	G-protein	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	ISS	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Ensembl=ENSBTAG00000009942|UniProtKB=E1BH60	Phosphoinositide phospholipase C	ISS			PTHR10336:SF84	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2
P00054	Toll receptor signaling pathway	P01369	MKK1	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00020	FAS signaling pathway	P00614	ASK1	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	TAS			PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00591	PLCbeta	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00059	p53 pathway	P01486	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	MACMU|Ensembl=ENSMMUG00000012875|UniProtKB=F6SFX7	Transcription initiation factor TFIID subunit 9-like protein	ISS			PTHR12595:SF3	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 9B
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02747	Histidine biosynthesis	P02992	Imidazol glycerol phosphate synthase	AQUAE|EnsemblGenome=aq_732|UniProtKB=O66943	Imidazole glycerol phosphate synthase subunit HisH	ISS			PTHR42701:SF1	IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISH
P00006	Apoptosis signaling pathway	P00274	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CANLF|Ensembl=ENSCAFG00000017575|UniProtKB=Q076A5	Myosin-4	ISS	89264452	PubMed	PTHR13140:SF657	MYOSIN-4
P00019	Endothelin signaling pathway	P00591	PLCbeta	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IGI	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00012	Cadherin signaling pathway	P00470	F-actin	HUMAN|HGNC=145|UniProtKB=P63267	Actin, gamma-enteric smooth muscle	IC	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01148	Grb2	MOUSE|MGI=MGI=1333842|UniProtKB=O89100	GRB2-related adaptor protein 2	ISS	11971956	PubMed	PTHR24418:SF299	GRB2-RELATED ADAPTER PROTEIN 2
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95816|UniProtKB=B1AS29	Glutamate receptor ionotropic, kainate 3	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00006	Apoptosis signaling pathway	P00311	GCKR	HUMAN|HGNC=6865|UniProtKB=Q8IVH8	Mitogen-activated protein kinase kinase kinase kinase 3	ISS			PTHR24361:SF205	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 3
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04393	Ras Pathway	P04558	p38	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00006	Apoptosis signaling pathway	P00259	TNF	RAT|RGD=1303162|UniProtKB=Q6MG45	Lymphotoxin B	ISS			PTHR11471:SF29	LYMPHOTOXIN-BETA
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00054	Toll receptor signaling pathway	P01356	ERK2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	DANRE|ZFIN=ZDB-GENE-060824-1|UniProtKB=C3PTE8	Beta-arrestin 1	ISS	9388255	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00056	VEGF signaling pathway	P01407	Erk	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00648	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00030	Hypoxia response via HIF activation	P00819	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01300	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00010	B cell activation	P00379	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IPI	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IDA	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	MOUSE|MGI=MGI=1931148|UniProtKB=Q9WV84	Nucleoside diphosphate kinase, mitochondrial	ISS			PTHR11349:SF49	NUCLEOSIDE DIPHOSPHATE KINASE, MITOCHONDRIAL
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	9199552	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00010	B cell activation	P00391	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IDA	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	BOVIN|Ensembl=ENSBTAG00000008059|UniProtKB=P41984	Muscarinic acetylcholine receptor M3	ISS	10069496	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	11256888	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000015241|UniProtKB=Q5IS72	D(3) dopamine receptor	ISS	2137198	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00012	Cadherin signaling pathway	P00470	F-actin	DANRE|ZFIN=ZDB-GENE-030131-172|UniProtKB=Q6IQR3	Actin, alpha, cardiac muscle 1a	IC	11889139	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00018	EGF receptor signaling pathway	P00562	p38	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	IGI	8925912	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12960248	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000019277|UniProtKB=H2QUQ1	Uncharacterized protein	ISS	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=107469|UniProtKB=Q8K3R3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	10934033	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00004	Alzheimer disease-presenilin pathway	P00137	Tip60	MONDO|Ensembl=ENSMODG00000009581|UniProtKB=F7AWF2	Histone acetyltransferase	ISS	11441186	PubMed	PTHR10615:SF124	HISTONE ACETYLTRANSFERASE KAT5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=1351344|UniProtKB=Q68ED2	Metabotropic glutamate receptor 7	ISS	12488551	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00047	PDGF signaling pathway	P01162	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00023	General transcription regulation	P00668	TFIIB	SULSO|EnsemblGenome=SSO0946|UniProtKB=P58110	Transcription initiation factor IIB 2	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P00018	EGF receptor signaling pathway	P00561	STAT	CHICK|Ensembl=ENSGALG00000003267|UniProtKB=Q6DV79	Signal transducer and activator of transcription 3	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	IC	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00644	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	12810719	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00019	Endothelin signaling pathway	P00566	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00055	Transcription regulation by bZIP transcription factor	P01390	TFIIA complex	CHICK|Ensembl=ENSGALG00000010576|UniProtKB=F1NKT1	Uncharacterized protein	ISS	600519	OMIM	PTHR12694:SF7	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00048	PI3 kinase pathway	P01189	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	MOUSE|MGI=MGI=96572|UniProtKB=P01325	Insulin-1	ISS			PTHR11454:SF24	INSULIN-1
P00005	Angiogenesis	P00213	FGF	PANTR|Ensembl=ENSPTRG00000017361|UniProtKB=H2QRP4	Fibroblast growth factor	ISS	12057924	PubMed	PTHR11486:SF86	FIBROBLAST GROWTH FACTOR 1
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=11431|UniProtKB=O14662	Syntaxin-16	IC			PTHR19957:SF83	SYNTAXIN-16
P02734	Chorismate biosynthesis	P02870	3-Phosphoshikimate-1-carboxyvinyl transferase	THEMA|EnsemblGenome=TM_0345|UniProtKB=Q9WYI0	3-phosphoshikimate 1-carboxyvinyltransferase	ISS			PTHR21090:SF5	PENTAFUNCTIONAL AROM POLYPEPTIDE
P00021	FGF signaling pathway	P00624	14-3-3	ORNAN|Ensembl=ENSOANG00000007305|UniProtKB=F6XW91	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00057	Wnt signaling pathway	P01432	Beta-Catenin	XENTR|Xenbase=XB-GENE-487200|UniProtKB=Q28GC2	Catenin (Cadherin associated protein), beta 1, 88kDa	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MOUSE|MGI=MGI=87904|UniProtKB=P60710	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DANRE|ZFIN=ZDB-GENE-041001-104|UniProtKB=Q5TZD4	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	PANTR|Ensembl=ENSPTRG00000004893|UniProtKB=H2Q5U4	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IGI	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	BOVIN|Ensembl=ENSBTAG00000004368|UniProtKB=F1MSU2	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=621025|UniProtKB=Q62711	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	12860966	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=3972|UniProtKB=Q12841	Follistatin-related protein 1	ISS	11266476	PubMed	PTHR10913:SF13	FOLLISTATIN-RELATED PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	DANRE|ZFIN=ZDB-GENE-990415-256|UniProtKB=F1QDT8	Uncharacterized protein	TAS	9759503	PubMed	PTHR11848:SF121	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01435	SWI/SNF	MOUSE|MGI=MGI=1935129|UniProtKB=Q91ZW3	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5	IDA	11532957	PubMed	PTHR10799:SF887	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	PANTR|Ensembl=ENSPTRG00000000543|UniProtKB=H2PYN8	Uncharacterized protein	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	ARATH|TAIR=AT4G09320|UniProtKB=P39207	Nucleoside diphosphate kinase 1	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00059	p53 pathway	P04626	GADD45	RAT|RGD=1309080|UniProtKB=Q5U3Z2	Growth arrest and DNA-damage-inducible 45 beta	IGI	10097101	PubMed	PTHR10411:SF5	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 BETA
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00034	Integrin signalling pathway	P00922	Collagen	HUMAN|HGNC=6144|UniProtKB=P53708	Integrin alpha-8	IDA			PTHR23220:SF5	INTEGRIN ALPHA-8
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	MACMU|Ensembl=ENSMMUG00000004596|UniProtKB=F6Q976	Protein-serine/threonine kinase	RCA			PTHR24355:SF27	G PROTEIN-COUPLED RECEPTOR KINASE 5
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05925	beta-ARR1	MOUSE|MGI=MGI=99473|UniProtKB=Q8BWG8	Beta-arrestin-1	RCA	11742073	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00034	Integrin signalling pathway	P00938	Cdc42	DROME|FlyBase=FBgn0010341|UniProtKB=P40793	Cdc42 homolog	IDA	12932731	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00009	Axon guidance mediated by netrin	P00366	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04393	Ras Pathway	P04578	Rho	BOVIN|Ensembl=ENSBTAG00000014299|UniProtKB=Q1RMJ6	Rho-related GTP-binding protein RhoC	ISS	14871999	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000022886|UniProtKB=E1BE29	Uncharacterized protein	ISS	8930069	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00052	TGF-beta signaling pathway	P01275	P38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	TAS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00018	EGF receptor signaling pathway	P00562	p38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	RAT|RGD=3425|UniProtKB=P97887	Presenilin-1	TAS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00054	Toll receptor signaling pathway	P01341	Elk1	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	11279280	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00036	Interleukin signaling pathway	P00965	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IC	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00644	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IGI	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01173	STAT	HUMAN|HGNC=11365|UniProtKB=Q14765	Signal transducer and activator of transcription 4	ISS	12496413	PubMed	PTHR11801:SF19	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 4
P04393	Ras Pathway	P04563	Ets	HUMAN|HGNC=3488|UniProtKB=P14921	Protein C-ets-1	IDA	3060801	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00029	Huntington disease	P00808	Caspase 8	PANTR|Ensembl=ENSPTRG00000012801|UniProtKB=H2QJ86	Caspase 8, apoptosis-related cysteine peptidase	ISS	11788820	PubMed	PTHR10454:SF162	CASPASE-8
P04393	Ras Pathway	P04542	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	9298898	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	DANRE|ZFIN=ZDB-GENE-021119-1|UniProtKB=F1QG18	Uncharacterized protein	ISS	2039532	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00029	Huntington disease	P00807	Actin	RAT|RGD=2027|UniProtKB=P63269	Actin, gamma-enteric smooth muscle	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P05913	Enkephalin release	P05972	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00029	Huntington disease	P00780	Microtubule	XENTR|Xenbase=XB-GENE-491121|UniProtKB=Q6P367	Tubulin, beta 2B	ISS	9454836	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00052	TGF-beta signaling pathway	P01275	P38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	TAS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00036	Interleukin signaling pathway	P00973	PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04663	Mdm2	MACMU|Ensembl=ENSMMUG00000011236|UniProtKB=F6WXF0	Uncharacterized protein	ISS			PTHR13844:SF20	PROTEIN MDM4
P00004	Alzheimer disease-presenilin pathway	P00134	Nectin 1alpha transmembrane fragment	MOUSE|MGI=MGI=1926483|UniProtKB=Q9JKF6	Nectin-1	IDA	12376527	PubMed	PTHR23277:SF69	NECTIN-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	CAEBR|Gene=CBG13013|UniProtKB=A8XGW3	Protein CBR-CDC-42	ISS			PTHR24072:SF192	CDC42 HOMOLOG
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00049	Parkinson disease	P01236	Casein kinase II	CANLF|Ensembl=ENSCAFG00000006946|UniProtKB=E2RHZ1	Uncharacterized protein	ISS	10617630	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00005	Angiogenesis	P00203	Erk	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	92020947	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00641	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00048	PI3 kinase pathway	P01199	Galpha	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	IC	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00010	B cell activation	P00371	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01153	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00048	PI3 kinase pathway	P01202	p85	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PANTR|Ensembl=ENSPTRG00000002086|UniProtKB=H2Q1A9	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00053	T cell activation	P01311	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00048	PI3 kinase pathway	P01182	Ras	DANRE|ZFIN=ZDB-GENE-040808-67|UniProtKB=Q6AZA4	K-ras	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	DANRE|ZFIN=ZDB-GENE-040426-2487|UniProtKB=Q803G3	Serine/threonine-protein phosphatase	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00644	p38	CAEEL|WormBase=WBGene00004056|UniProtKB=Q8MXI4	Mitogen-activated protein kinase pmk-2	ISS	11707292	PubMed	PTHR24055:SF154	MITOGEN-ACTIVATED PROTEIN KINASE PMK-2
P00045	Notch signaling pathway	P01112	CoR	HUMAN|HGNC=7673|UniProtKB=Q9Y618	Nuclear receptor corepressor 2	TAS	10441327	PubMed	PTHR13992:SF21	NUCLEAR RECEPTOR COREPRESSOR 2
P00012	Cadherin signaling pathway	P00470	F-actin	HUMAN|HGNC=144|UniProtKB=P63261	Actin, cytoplasmic 2	IC	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01440	Cadherin	SYNY3|Gene=BAA17114|UniProtKB=P73089	Fat protein	ISS	8120095	PubMed	PTHR24026:SF70	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	DANRE|ZFIN=ZDB-GENE-991119-4|UniProtKB=Q9W6T7	Presenilin-1	IDA	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01428	Frizzled	DANRE|ZFIN=ZDB-GENE-000328-4|UniProtKB=B0S6S2	Uncharacterized protein	IDA	8717036	PubMed	PTHR11309:SF90	FRIZZLED-8
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00060	Ubiquitin proteasome pathway	P01492	E1	MACMU|Ensembl=ENSMMUG00000009506|UniProtKB=F6YMX6	Uncharacterized protein	ISS			PTHR10953:SF162	SUMO-ACTIVATING ENZYME SUBUNIT 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=11331|UniProtKB=P30874	Somatostatin receptor type 2	IDA	12181435	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P02772	Pyruvate metabolism	P03137	Citrate Lyase	STRCO|Gene=CAB51425|UniProtKB=Q9S2U9	Putative citrate lyase beta chain	ISS			PTHR32308:SF0	CITRATE LYASE SUBUNIT BETA
P00006	Apoptosis signaling pathway	P00260	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00014	Cholesterol biosynthesis	P00500	Phosphomevalonate kinase	MACMU|Ensembl=ENSMMUG00000002027|UniProtKB=F6TMG1	Phosphomevalonate kinase	ISS			PTHR13101:SF1	PHOSPHOMEVALONATE KINASE
P00006	Apoptosis signaling pathway	P00269	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00010	B cell activation	P00391	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00274	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00012	Cadherin signaling pathway	P00474	Wnt	CANLF|Ensembl=ENSCAFG00000031321|UniProtKB=J9NZJ2	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01087	CAT	HUMAN|HGNC=1912|UniProtKB=P28329	Choline O-acetyltransferase	IC	92155737	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000000365|UniProtKB=F6R9F4	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04393	Ras Pathway	P04572	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000002647|UniProtKB=F7DIB7	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	RAT|RGD=2746|UniProtKB=P31424	Metabotropic glutamate receptor 5	ISS	7476890	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	IDA	11707292	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00034	Integrin signalling pathway	P00907	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01167	Ets	MACMU|Ensembl=ENSMMUG00000018953|UniProtKB=F6YE27	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF206	ETS TRANSLOCATION VARIANT 2
P00010	B cell activation	P00369	MEKK	HUMAN|HGNC=6854|UniProtKB=Q9Y2U5	Mitogen-activated protein kinase kinase kinase 2	IDA	8649450	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MACMU|Ensembl=ENSMMUG00000014227|UniProtKB=P56490	Muscarinic acetylcholine receptor M5	TAS	10069496	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	MACMU|Ensembl=ENSMMUG00000010269|UniProtKB=F6PVP0	Uncharacterized protein	ISS			PTHR11405:SF5	CAD PROTEIN
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	15621031	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	XENTR|Xenbase=XB-GENE-494200|UniProtKB=F7CS79	Uncharacterized protein	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IDA	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	ORYSJ|EnsemblGenome=OS06G0564500|UniProtKB=Q5Z8Y9	Cysteine synthase	ISS			PTHR10314:SF114	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00005	Angiogenesis	P00236	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00269	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	12657601	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00018	EGF receptor signaling pathway	P00565	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00049	Parkinson disease	P01211	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00012	Cadherin signaling pathway	P00474	Wnt	PANTR|Ensembl=ENSPTRG00000012931|UniProtKB=H2QJF8	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DANRE|ZFIN=ZDB-GENE-000329-1|UniProtKB=Q7ZVI7	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P02738	De novo purine biosynthesis	P02891	GDP kinase	CANLF|Ensembl=ENSCAFG00000015252|UniProtKB=F1PMF2	Uncharacterized protein	ISS			PTHR43109:SF2	NUCLEOSIDE DIPHOSPHATE KINASE 7
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_115566|UniProtKB=C3XYC8	Putative uncharacterized protein	IDA	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	IDA	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	CHICK|Ensembl=ENSGALG00000008898|UniProtKB=F1P2J9	Uncharacterized protein	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	RAT|RGD=2156|UniProtKB=P29066	Beta-arrestin-1	ISS	4757780	gi	PTHR11792:SF22	BETA-ARRESTIN-1
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	CHICK|Gene=CHRM4|UniProtKB=P17200	Muscarinic acetylcholine receptor M4	TAS	11166329	PubMed	PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P02743	Formyltetrahydroformate biosynthesis	P02953	Cobalamin dependent homocysteine transmethylase	MYCTU|EnsemblGenome=LH57_13435|UniProtKB=O53185	Homocysteine methyltransferase	ISS			PTHR21091:SF123	FI01821P
P00046	Oxidative stress response	P01135	p38	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	8920915	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00060	Ubiquitin proteasome pathway	P01491	E2	HUMAN|HGNC=12478|UniProtKB=Q96LR5	Ubiquitin-conjugating enzyme E2 E2	ISS			PTHR24068:SF62	UBIQUITIN-CONJUGATING ENZYME E2 E2
P05918	p38 MAPK pathway	P06015	p38gamma	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	RCA	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00046	Oxidative stress response	P01138	MKK4	CANLF|Ensembl=ENSCAFG00000017851|UniProtKB=F1PBB6	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	94280860	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00019	Endothelin signaling pathway	P00591	PLCbeta	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IGI	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00052	TGF-beta signaling pathway	P01286	TGFbeta	DANRE|ZFIN=ZDB-GENE-041020-1|UniProtKB=O57460	Dorsal-ventral patterning tolloid-like protein 1	TAS	9759503	PubMed	PTHR43978:SF4	TOLLOID-LIKE PROTEIN 1
P00048	PI3 kinase pathway	P01189	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	TAS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01080	AChE	DANRE|ZFIN=ZDB-GENE-010906-1|UniProtKB=Q9DDE3	Acetylcholinesterase	ISS	87080761	PubMed	PTHR43918:SF3	ACETYLCHOLINESTERASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	MACMU|Ensembl=ENSMMUG00000021442|UniProtKB=F7EAQ8	Muscarinic acetylcholine receptor	ISS	8100450	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00046	Oxidative stress response	P01131	MKP5	BOVIN|Ensembl=ENSBTAG00000001729|UniProtKB=Q0IID7	Dual specificity protein phosphatase 10	ISS	10597297	PubMed	PTHR10159:SF299	DUAL SPECIFICITY PROTEIN PHOSPHATASE 10
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00034	Integrin signalling pathway	P00942	Fyn	MONDO|Ensembl=ENSMODG00000017905|UniProtKB=F7FG65	Tyrosine-protein kinase	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00052	TGF-beta signaling pathway	P01275	P38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00029	Huntington disease	P00763	Hip-12	MOUSE|MGI=MGI=1352504|UniProtKB=Q9JKY5	Huntingtin-interacting protein 1-related protein	RCA			PTHR10407:SF10	HUNTINGTIN-INTERACTING PROTEIN 1-RELATED PROTEIN
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00029	Huntington disease	P00786	ARF	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g242285|UniProtKB=A7S214	Predicted protein	ISS	12932731	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DAPPU|EnsemblGenome=DAPPUDRAFT_228751|UniProtKB=E9HGF5	Cytoplasmatic actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	HUMAN|HGNC=3025|UniProtKB=P21917	D(4) dopamine receptor	ISS	11248120	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00060	Ubiquitin proteasome pathway	P01491	E2	ORYSJ|EnsemblGenome=OS01G0925800|UniProtKB=Q8S1Y5	Os01g0925800 protein	ISS			PTHR44020:SF2	UBIQUITIN-CONJUGATING ENZYME E2 K
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02768	Proline biosynthesis	P03112	Glutamate semialdehyde dehydrogenase	SYNY3|EnsemblGenome=BAA10306|UniProtKB=Q55167	Gamma-glutamyl phosphate reductase 2	ISS			PTHR11063:SF8	DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04393	Ras Pathway	P04570	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01189	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00056	VEGF signaling pathway	P01408	Akt/PKB	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01425	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	10395542	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P05916	Opioid prodynorphin pathway	P06001	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	PANTR|Ensembl=ENSPTRG00000003795|UniProtKB=H2Q3X5	Muscarinic acetylcholine receptor	ISS	8100450	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P04393	Ras Pathway	P04546	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	RAT|RGD=621665|UniProtKB=Q9JHX0	Regulator of G-protein signaling 2	ISS	8756726	PubMed	PTHR10845:SF43	REGULATOR OF G-PROTEIN SIGNALING 2
P00047	PDGF signaling pathway	P01168	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01174	Rho	MOUSE|MGI=MGI=1354949|UniProtKB=Q9R0Z9	Rho GTPase-activating protein 7	ISS			PTHR12659:SF2	RHO GTPASE-ACTIVATING PROTEIN 7
P00021	FGF signaling pathway	P00629	PP2A	DANRE|ZFIN=ZDB-GENE-040426-2700|UniProtKB=A5PMV7	Uncharacterized protein	ISS			PTHR10648:SF4	PROTEIN PHOSPHATASE 2  FORMERLY 2A , REGULATORY SUBUNIT A, BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	XENTR|Xenbase=XB-GENE-961282|UniProtKB=Q6DF43	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00053	T cell activation	P01336	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04398	p53 pathway feedback loops 2	P04661	PI3K	DROME|FlyBase=FBgn0015278|UniProtKB=Q7K3H0	LD28067p	ISS	8662856	PubMed	PTHR10048:SF64	LD28067P
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00034	Integrin signalling pathway	P00939	Fibronectin	BOVIN|Gene=FN1|UniProtKB=P07589	Fibronectin	ISS	12970173	PubMed	PTHR19143:SF267	FIBRONECTIN
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01414	PLC-gamma	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00049	Parkinson disease	P01211	ERK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	IDA	11707292	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MOUSE|MGI=MGI=103301|UniProtKB=Q8R0S4	Voltage-dependent L-type calcium channel subunit beta-4	IC			PTHR11824:SF7	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	CANLF|Gene=ADCY6|UniProtKB=P30804	Adenylate cyclase type 6	IGI	2491850	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00045	Notch signaling pathway	P01117	Neuralized	HUMAN|HGNC=34410|UniProtKB=Q96JN8	Neuralized-like protein 4	RCA			PTHR12429:SF14	NEURALIZED-LIKE PROTEIN 4
P00046	Oxidative stress response	P01126	ATF2	CANLF|Ensembl=ENSCAFG00000013332|UniProtKB=F1PCQ4	Uncharacterized protein	ISS	15218628	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P04393	Ras Pathway	P04551	RalGDS	MOUSE|MGI=MGI=107485|UniProtKB=Q03385	Ral guanine nucleotide dissociation stimulator	IDA	8094051	PubMed	PTHR23113:SF35	RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR
P00029	Huntington disease	P00807	Actin	MACMU|Ensembl=ENSMMUG00000001353|UniProtKB=F7D6T8	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MOUSE|MGI=MGI=1354739|UniProtKB=Q9Z2H1	Regulator of G-protein signaling 11	IDA	8756726	PubMed	PTHR10845:SF144	REGULATOR OF G-PROTEIN SIGNALING 11
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IGI	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00030	Hypoxia response via HIF activation	P00824	PTEN	DICDI|dictyBase=DDB_G0286557|UniProtKB=Q8T9S7	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS			PTHR12305:SF79	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P02774	Salvage pyrimidine deoxyribonucleotides	P03148	Thymidine phosphorylase	THEMA|EnsemblGenome=TM_1653|UniProtKB=Q9S5X9	Pyrimidine-nucleoside phosphorylase	ISS	8824600	PubMed	PTHR10515:SF0	THYMIDINE PHOSPHORYLASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	RAT|RGD=2746|UniProtKB=P31424	Metabotropic glutamate receptor 5	IDA	12351712	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P02753	Methionine biosynthesis	P03023	Homoserine succinyltransferase	THEMA|EnsemblGenome=TM_0881|UniProtKB=Q9WZY3	Homoserine O-succinyltransferase	ISS			PTHR20919:SF0	HOMOSERINE O-SUCCINYLTRANSFERASE
P00010	B cell activation	P00391	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00317	Fos	BOVIN|Ensembl=ENSBTAG00000004322|UniProtKB=O77628	Proto-oncogene c-Fos	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00044	Nicotinic acetylcholine receptor signaling pathway	P01093	AChE	ANOGA|EnsemblGenome=AGAP000466|UniProtKB=Q7QFG0	Carboxylic ester hydrolase	IC	86008285	PubMed	PTHR43918:SF4	ACETYLCHOLINESTERASE
P00047	PDGF signaling pathway	P01159	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	RAT|RGD=3570|UniProtKB=P49803	Regulator of G-protein signaling 7	IDA	8756726	PubMed	PTHR10845:SF26	REGULATOR OF G-PROTEIN SIGNALING 7
P00005	Angiogenesis	P00219	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	HUMAN|HGNC=9199|UniProtKB=P62875	DNA-directed RNA polymerases I, II, and III subunit RPABC5	ISS			PTHR23431:SF3	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5
P00021	FGF signaling pathway	P00627	ERK1-2	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	NAS	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00012	Cadherin signaling pathway	P00475	Frizzled	MOUSE|MGI=MGI=1888513|UniProtKB=Q9JIP6	Frizzled-2	IDA	8717036	PubMed	PTHR11309:SF34	FRIZZLED-2
P00012	Cadherin signaling pathway	P00471	Cadherin	BOVIN|Gene=CDH2|UniProtKB=P19534	Cadherin-2 (Fragment)	IDA	8120095	PubMed	PTHR24027:SF79	CADHERIN-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-2555|UniProtKB=F8W3G9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00029	Huntington disease	P00801	Fos protein	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	TAS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	10218114	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g169611|UniProtKB=A7SEB1	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	10218114	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	HUMAN|HGNC=2561|UniProtKB=P61073	C-X-C chemokine receptor type 4	IDA	11591799	PubMed	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00036	Interleukin signaling pathway	P00973	PKB	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05755	Gbeta	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00519	ROCK	MONDO|Ensembl=ENSMODG00000021484|UniProtKB=F7G2Y1	Uncharacterized protein	ISS	10779382	PubMed	PTHR22988:SF33	RHO-ASSOCIATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04657	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00560	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00475	Frizzled	MOUSE|MGI=MGI=2136761|UniProtKB=Q8BKG4	Frizzled-10	ISS	11212302	PubMed	PTHR11309:SF86	FRIZZLED-10
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	RAT|RGD=67399|UniProtKB=Q64716	Insulin receptor-related protein	ISS	6754360	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00009	Axon guidance mediated by netrin	P00363	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05731	GABA-B receptor II signaling	P05755	Gbeta	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00029	Huntington disease	P00801	Fos protein	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	TAS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	DANRE|ZFIN=ZDB-GENE-000330-9|UniProtKB=Q90ZE4	Presenilin-2	IDA	12424519	PubMed	PTHR10202:SF13	PRESENILIN-2
P00047	PDGF signaling pathway	P01174	Rho	MOUSE|MGI=MGI=1922665|UniProtKB=Q8C0D4	Rho GTPase-activating protein 12	ISS			PTHR23181:SF3	RHO GTPASE-ACTIVATING PROTEIN 12
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CAEEL|WormBase=WBGene00004038|UniProtKB=Q22070	Phosphoinositide phospholipase C	ISS			PTHR10336:SF91	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00057	Wnt signaling pathway	P01457	GBeta	DICDI|dictyBase=DDB_G0277143|UniProtKB=P36408	Guanine nucleotide-binding protein subunit beta	IDA	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00052	TGF-beta signaling pathway	P01275	P38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00034	Integrin signalling pathway	P00951	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	88234494	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00035	Interferon-gamma signaling pathway	P00952	Jak2	CANLF|Ensembl=ENSCAFG00000002102|UniProtKB=E2RPW6	Tyrosine-protein kinase	ISS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00010	B cell activation	P00367	NFAT	CANLF|Ensembl=ENSCAFG00000011625|UniProtKB=F1PDD9	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	91072385	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00053	T cell activation	P01321	SLP-76	PANTR|Ensembl=ENSPTRG00000017517|UniProtKB=H2QRZ6	Uncharacterized protein	ISS	9665884	PubMed	PTHR14098:SF1	LYMPHOCYTE CYTOSOLIC PROTEIN 2
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CANLF|Ensembl=ENSCAFG00000002617|UniProtKB=E2QUL1	Uncharacterized protein	ISS	11554549	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	RAT|RGD=3238|UniProtKB=P01179	Oxytocin-neurophysin 1	ISS	6717565	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00030	Hypoxia response via HIF activation	P00818	HIF-1alpha	HUMAN|HGNC=4910|UniProtKB=Q16665	Hypoxia-inducible factor 1-alpha	TAS	9606183	PubMed	PTHR23043:SF7	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA
P00047	PDGF signaling pathway	P01175	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	7680960	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00049	Parkinson disease	P01207	PLD2	PANTR|Ensembl=ENSPTRG00000008610|UniProtKB=H2QBY9	Uncharacterized protein	ISS	12615079	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00049	Parkinson disease	P01238	14-3-3	ORYSJ|EnsemblGenome=OS08G0480800|UniProtKB=Q84J55	14-3-3-like protein GF14-A	ISS	20493542	PubMed	PTHR18860:SF26	14-3-3 FAMILY PROTEIN-RELATED
P00060	Ubiquitin proteasome pathway	P01490	E3	MOUSE|MGI=MGI=1891295|UniProtKB=Q9ES34	Ubiquitin-protein ligase E3B	ISS			PTHR11254:SF352	UBIQUITIN-PROTEIN LIGASE E3B
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	ISS	1482697	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	MACMU|Ensembl=ENSMMUG00000010122|UniProtKB=F7HF84	Casein kinase I isoform epsilon	ISS	11865049	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05918	p38 MAPK pathway	P05920	MAPKAP-K2	BOVIN|Ensembl=ENSBTAG00000038107|UniProtKB=F1MCX5	Uncharacterized protein	ISS	8262198	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT1G01560|UniProtKB=Q9LMM5	Mitogen-activated protein kinase 11	ISS	9836510	gi	PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05913	Enkephalin release	P05972	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	ANOGA|EnsemblGenome=AGAP008908|UniProtKB=Q7PWN2	AGAP008908-PA	ISS	12932731	PubMed	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P04393	Ras Pathway	P04567	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00053	T cell activation	P01332	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00260	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00566	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	BOVIN|Ensembl=ENSBTAG00000037616|UniProtKB=F1MUD1	Uncharacterized protein	ISS	2433589	PubMed	PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P00008	Axon guidance mediated by Slit/Robo	P00352	DCC	MACMU|Ensembl=ENSMMUG00000013999|UniProtKB=F6RRI0	Uncharacterized protein	ISS	12810718	PubMed	PTHR44146:SF3	NETRIN RECEPTOR DCC
P00018	EGF receptor signaling pathway	P00541	Spry	PANTR|Ensembl=ENSPTRG00000041677|UniProtKB=H2RH98	Uncharacterized protein	ISS			PTHR12365:SF9	PROTEIN SPROUTY HOMOLOG 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00182	p38MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000017374|UniProtKB=F7H6T7	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00010	B cell activation	P00381	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	IGI	3449797	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	SCHPO|PomBase=SPBC342.02|UniProtKB=Q9Y7Y8	Probable glutamine--tRNA ligase	ISS			PTHR43097:SF4	GLUTAMINE--TRNA LIGASE-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00034	Integrin signalling pathway	P00920	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	RCA			PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00282	IGFR2	RAT|RGD=2871|UniProtKB=G3V824	Insulin-like growth factor 2 receptor, isoform CRA_b	IDA	13642251	gi	PTHR15071:SF17	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	SCHPO|PomBase=SPAC23C4.12|UniProtKB=P40236	Casein kinase I homolog hhp2	IDA	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00091	Aph-1	RAT|RGD=1311546|UniProtKB=A0A0G2K6H8	Anterior pharynx defective 1a homolog (C. elegans), isoform CRA_a	IDA	12110170	PubMed	PTHR12889:SF3	GAMMA-SECRETASE SUBUNIT APH-1A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MOUSE|MGI=MGI=87909|UniProtKB=P62737	Actin, aortic smooth muscle	IC	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00034	Integrin signalling pathway	P00921	PINCH	HUMAN|HGNC=6616|UniProtKB=P48059	LIM and senescent cell antigen-like-containing domain protein 1	IPI	10022929	PubMed	PTHR24210:SF11	LIM AND SENESCENT CELL ANTIGEN-LIKE-CONTAINING DOMAIN PROTEIN 1-RELATED
P06664	Gonadotropin-releasing hormone receptor pathway	P06743	Cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	RCA	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P06959	CCKR signaling map	P07090	MAPK8-10	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	RCA	15153424	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04574	PLD	MOUSE|MGI=MGI=109585|UniProtKB=Q9Z280	Phospholipase D1	IDA	9307024	PubMed	PTHR18896:SF57	PHOSPHOLIPASE D1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P02747	Histidine biosynthesis	P02992	Imidazol glycerol phosphate synthase	GLOVI|EnsemblGenome=BAC88348|UniProtKB=Q7NNK4	Imidazole glycerol phosphate synthase subunit HisH	ISS			PTHR42701:SF1	IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISH
P00021	FGF signaling pathway	P00633	Ras	CANAL|EnsemblGenome=CaO19.1760|UniProtKB=Q59XU5	Ras-like protein 1	IGI	10515923	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P04611	P300	HUMAN|HGNC=3373|UniProtKB=Q09472	Histone acetyltransferase p300	ISS	10769018	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	BOVIN|Ensembl=ENSBTAG00000011803|UniProtKB=F1MTZ2	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF427	MYOSIN-3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00562	p38	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00018	EGF receptor signaling pathway	P00560	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00475	Frizzled	HUMAN|HGNC=4044|UniProtKB=O60353	Frizzled-6	IDA	11212302	PubMed	PTHR11309:SF75	FRIZZLED-6
P00019	Endothelin signaling pathway	P00572	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000012036|UniProtKB=F7ALP1	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	BOVIN|Ensembl=ENSBTAG00000047202|UniProtKB=G3N3K3	Uncharacterized protein	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00047	PDGF signaling pathway	P01154	Ras	BOVIN|Ensembl=ENSBTAG00000009778|UniProtKB=E1BMX0	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P02738	De novo purine biosynthesis	P02902	ADP reductase	CHLTR|EnsemblGenome=CT_827|UniProtKB=O84834	Ribonucleoside-diphosphate reductase subunit alpha	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00591	PLCbeta	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IGI	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00049	Parkinson disease	P01227	20S proteasome	TAKRU|Ensembl=ENSTRUG00000008890|UniProtKB=H2TCF6	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF12	PROTEASOME SUBUNIT ALPHA TYPE-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_127489|UniProtKB=C3XYC6	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00007	Axon guidance mediated by semaphorins	P00328	plexinB1	MACMU|Ensembl=ENSMMUG00000003074|UniProtKB=F6U213	Uncharacterized protein	ISS			PTHR22625:SF36	PLEXIN-B1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P06664	Gonadotropin-releasing hormone receptor pathway	P06786	ERK1/2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	RCA	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000010195|UniProtKB=E1B7J3	Uncharacterized protein	ISS	11554554	PubMed	PTHR24356:SF175	SERINE/THREONINE-PROTEIN KINASE N3
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	BOVIN|Ensembl=ENSBTAG00000000312|UniProtKB=Q32L53	Protein lifeguard 1	ISS			PTHR23291:SF16	PROTEIN LIFEGUARD 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00566	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	IC	10704417	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00057	Wnt signaling pathway	P01435	SWI/SNF	PLAF7|EnsemblGenome=PF11_0053|UniProtKB=Q8IIW0	Chromatin remodeling protein	IDA	11532957	PubMed	PTHR10799:SF879	CHROMATIN-REMODELING COMPLEX ATPASE CHAIN ISWI
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04398	p53 pathway feedback loops 2	G04715	CYCLIN G	MONDO|Ensembl=ENSMODG00000007651|UniProtKB=F7FZG0	Uncharacterized protein	ISS	11983168	PubMed	PTHR10177:SF59	CYCLIN-G1
P00029	Huntington disease	P00795	BDNF	DANRE|ZFIN=ZDB-GENE-000412-1|UniProtKB=Q6NZ01	Bdnf protein	TAS	11724916	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00052	TGF-beta signaling pathway	P01286	TGFbeta	HUMAN|HGNC=1075|UniProtKB=P34820	Bone morphogenetic protein 8B	TAS	9759503	PubMed	PTHR11848:SF173	BONE MORPHOGENETIC PROTEIN 8B
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	BOVIN|Ensembl=ENSBTAG00000010111|UniProtKB=F1MJS2	Uncharacterized protein	ISS	11266476	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00052	TGF-beta signaling pathway	P01275	P38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00053	T cell activation	P01300	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00910	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12748278	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00015	Circadian clock system	P00501	Clock	MACMU|Ensembl=ENSMMUG00000001919|UniProtKB=F6TZT0	Uncharacterized protein	ISS	8171325	PubMed	PTHR23042:SF2	CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT
P00053	T cell activation	P01322	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01472	Histone deacetylase	BOVIN|Gene=HDAC8|UniProtKB=Q0VCB2	Histone deacetylase 8	ISS	10485845	PubMed	PTHR10625:SF142	HISTONE DEACETYLASE 8
P00012	Cadherin signaling pathway	P00462	Casein kinase II	PANTR|Ensembl=ENSPTRG00000008175|UniProtKB=H2RA57	Uncharacterized protein	ISS	10617630	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	TAS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00048	PI3 kinase pathway	P01179	PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01331	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IDA	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01447	Dishevelled	MOUSE|MGI=MGI=94941|UniProtKB=P51141	Segment polarity protein dishevelled homolog DVL-1	ISS	12549854	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P02746	Heme biosynthesis	P02982	Protoheme IX farnesyl transferase	ORYSJ|EnsemblGenome=OS01G0527700|UniProtKB=Q5QLH9	Os01g0527700 protein	ISS			PTHR43448:SF2	PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00034	Integrin signalling pathway	P00925	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IDA	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00048	PI3 kinase pathway	P01198	FOXO	MOUSE|MGI=MGI=1890081|UniProtKB=Q9WVH4	Forkhead box protein O3	TAS	14775847	gi	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	MOUSE|MGI=MGI=104755|UniProtKB=P48545	G protein-activated inward rectifier potassium channel 4	ISS	12374786	PubMed	PTHR11767:SF52	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 4
P00045	Notch signaling pathway	P01099	Notch	HUMAN|HGNC=7882|UniProtKB=Q04721	Neurogenic locus notch homolog protein 2	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	TAS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01208	Hsp70	MOUSE|MGI=MGI=96244|UniProtKB=Q61696	Heat shock 70 kDa protein 1A	IDA	12150907	PubMed	PTHR19375:SF223	HEAT SHOCK 70 KDA PROTEIN 1A-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P02783	Tryptophan biosynthesis	P03206	Anthranilate synthase	PSEAE|EnsemblGenome=PA1758|UniProtKB=Q9I2Y1	Para-aminobenzoate synthase component I	ISS			PTHR11236:SF18	AMINODEOXYCHORISMATE SYNTHASE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00475	Frizzled	XENTR|Xenbase=XB-GENE-478210|UniProtKB=F6V5F4	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF23	FRIZZLED-4
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02757	O-antigen biosynthesis	P03050	dTDP-4-dehydrorhamnose reductase	AQUAE|EnsemblGenome=aq_518|UniProtKB=O66803	Spore coat polysaccharide biosynthesis protein SpsK	ISS			PTHR10491:SF4	METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	CANLF|Ensembl=ENSCAFG00000020105|UniProtKB=B4YY02	Adenylate kinase isoenzyme 1	ISS			PTHR23359:SF59	ADENYLATE KINASE ISOENZYME 1
P00012	Cadherin signaling pathway	P00470	F-actin	SCHMA|EnsemblGenome=Smp_046600|UniProtKB=G4VLW2	Putative actin-1	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00052	TGF-beta signaling pathway	P01286	TGFbeta	XENTR|Xenbase=XB-GENE-480560|UniProtKB=F6ZYQ1	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF141	TRANSFORMING GROWTH FACTOR BETA-2
P00021	FGF signaling pathway	P00645	Rac	DICDI|dictyBase=DDB_G0279605|UniProtKB=P34148	Rho-related protein racB	ISS	12932731	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	TAS	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00021	FGF signaling pathway	P00632	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00021	FGF signaling pathway	P00629	PP2A	DICDI|dictyBase=DDB_G0290263|UniProtKB=Q9XZE5	Serine/threonine-protein phosphatase 2A catalytic subunit A	IDA	99379588	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06785	ELK1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	RCA	11050086	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	ISS	15313841	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P06664	Gonadotropin-releasing hormone receptor pathway	P06812	L-type Ca2+	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	RCA	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P02748	Isoleucine biosynthesis	P02998	Dihydroxyacid dehydratase	DEIRA|EnsemblGenome=DR_1132|UniProtKB=Q9RV97	Dihydroxy-acid dehydratase	ISS			PTHR43661:SF3	DIHYDROXY-ACID DEHYDRATASE
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	RAT|RGD=2521|UniProtKB=P19020	D(3) dopamine receptor	RCA	11861492	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00020	FAS signaling pathway	P00614	ASK1	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS			PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02756	N-acetylglucosamine metabolism	P03036	N-acetylglucosamine-6-phosphate deacetylase	BACSU|EnsemblGenome=BSU35010|UniProtKB=O34450	N-acetylglucosamine-6-phosphate deacetylase	ISS			PTHR11113:SF1	N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000002016|UniProtKB=F1P3G1	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MOUSE|MGI=MGI=1933206|UniProtKB=A2AIR5	Protein Grin3a	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00047	PDGF signaling pathway	P01150	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02751	Lysine biosynthesis	P03009	Aspartokinase	STRCO|Gene=CAB45482|UniProtKB=Q9XAI7	Aspartokinase	ISS			PTHR21499:SF3	ASPARTOKINASE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CANLF|Ensembl=ENSCAFG00000015708|UniProtKB=F2Z4N0	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00005	Angiogenesis	P00221	JNK1	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CAEEL|WormBase=WBGene00018569|UniProtKB=Q7JP68	cAMP-dependent protein kinase, catalytic subunit-like	ISS	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00006	Apoptosis signaling pathway	P00318	PKCs	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00025	Hedgehog signaling pathway	P00682	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	BOVIN|Ensembl=ENSBTAG00000020590|UniProtKB=G3N2W8	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF34	FRIZZLED-2
P00057	Wnt signaling pathway	P01428	Frizzled	ORNAN|Ensembl=ENSOANG00000008874|UniProtKB=F7F2K2	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF23	FRIZZLED-4
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	XENTR|Xenbase=XB-GENE-956713|UniProtKB=Q5XGD8	Guanine nucleotide binding protein, beta 3	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00034	Integrin signalling pathway	P00923	Arf1	TAKRU|Ensembl=ENSTRUG00000006254|UniProtKB=H2SS82	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	DANRE|ZFIN=ZDB-GENE-050522-384|UniProtKB=F1QKY8	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	XENTR|Xenbase=XB-GENE-977853|UniProtKB=F7EBE7	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00010	B cell activation	P00375	Calmodulin	BRAFL|Gene=BRAFLDRAFT_124869|UniProtKB=C3ZEW0	Putative uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF263	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DROME|FlyBase=FBgn0015765|UniProtKB=O62618	Mitogen-activated protein kinase 14A	IDA	10514528	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00643	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	IDA	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00749	RGS9	PANTR|Ensembl=ENSPTRG00000009552|UniProtKB=H2QDP8	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF170	REGULATOR OF G-PROTEIN SIGNALING 9
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	8920915	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00053	T cell activation	P01332	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00029	Huntington disease	P00807	Actin	XENTR|Xenbase=XB-GENE-491938|UniProtKB=Q6DIV8	Actin, alpha 1, skeletal muscle	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00001	Adrenaline and noradrenaline biosynthesis	P00070	VAT2	MACMU|Ensembl=ENSMMUG00000014817|UniProtKB=F6VXD8	Uncharacterized protein	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00021	FGF signaling pathway	P00645	Rac	ORYSJ|EnsemblGenome=OS02G0312600|UniProtKB=Q6Z7L8	Rac-like GTP-binding protein 7	ISS			PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	20264070	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05913	Enkephalin release	P05978	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P02748	Isoleucine biosynthesis	P02997	Acetolactate synthase	PANTR|Ensembl=ENSPTRG00000010614|UniProtKB=H2QFL7	IlvB (Bacterial acetolactate synthase)-like	ISS			PTHR18968:SF155	ACETOLACTATE SYNTHASE-LIKE PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00018	EGF receptor signaling pathway	P00559	MEK1-2	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00012	Cadherin signaling pathway	P00475	Frizzled	RAT|RGD=71012|UniProtKB=Q08464	Frizzled-2	IDA	11212302	PubMed	PTHR11309:SF34	FRIZZLED-2
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00025	Hedgehog signaling pathway	P00683	Slimb	HUMAN|HGNC=13607|UniProtKB=Q9UKB1	F-box/WD repeat-containing protein 11	ISS	12628165	PubMed	PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P00021	FGF signaling pathway	P00638	PLCgamma	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	TAS	12655147	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	LEIMA|EnsemblGenome=LmjF.18.1080|UniProtKB=Q27687	Protein kinase A catalytic subunit	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01154	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MOUSE|MGI=MGI=88399|UniProtKB=P32211	Muscarinic acetylcholine receptor M4	TAS	11166329	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00037	Ionotropic glutamate receptor pathway	P01023	CaMKII	MOUSE|MGI=MGI=88256|UniProtKB=P11798	Calcium/calmodulin-dependent protein kinase type II subunit alpha	ISS	12888804	PubMed	PTHR43940:SF5	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA
P00005	Angiogenesis	P00238	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ARATH|TAIR=AT2G42100|UniProtKB=Q8RYC2	Putative actin-5	IC	11889126	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P05915	Opioid proenkephalin pathway	P05994	G-protein	TAKRU|Ensembl=ENSTRUG00000011297|UniProtKB=H2TV18	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00059	p53 pathway	G01579	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	IGI	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00010	B cell activation	P00376	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00019	Endothelin signaling pathway	P00591	PLCbeta	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	HUMAN|HGNC=1402|UniProtKB=Q08289	Voltage-dependent L-type calcium channel subunit beta-2	IDA	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P05918	p38 MAPK pathway	P06018	MNK1	MACMU|Ensembl=ENSMMUG00000020162|UniProtKB=F6TJV6	Uncharacterized protein	ISS	Q9BUB5	SPACC	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	IC	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEEL|WormBase=WBGene00004033|UniProtKB=P90980	Protein kinase C-like 2	ISS	3045562	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IDA	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	RAT|RGD=61862|UniProtKB=P19491	Glutamate receptor 2	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00012	Cadherin signaling pathway	P00474	Wnt	TAKRU|Ensembl=ENSTRUG00000007912|UniProtKB=H2T4W3	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF83	PROTEIN WNT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	BOVIN|Ensembl=ENSBTAG00000000219|UniProtKB=F1MCL3	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P06664	Gonadotropin-releasing hormone receptor pathway	P06827	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	RCA	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00052	TGF-beta signaling pathway	P01286	TGFbeta	RAT|RGD=2213|UniProtKB=Q06826	Bone morphogenetic protein 4	TAS	9759503	PubMed	PTHR11848:SF165	BONE MORPHOGENETIC PROTEIN 4
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05913	Enkephalin release	P05972	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	ARATH|TAIR=AT1G16710|UniProtKB=Q9FWQ5	Histone acetyltransferase HAC12	TAS	10664585	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P02783	Tryptophan biosynthesis	P03208	Tryptophan synthase B	ARATH|TAIR=AT5G38530|UniProtKB=Q9FFW8	Tryptophan synthase beta chain	ISS			PTHR43565:SF1	TRYPTOPHAN SYNTHASE BETA CHAIN
P04395	Vasopressin synthesis	P04599	Amidating Enzyme	PANTR|Ensembl=ENSPTRG00000005803|UniProtKB=H2Q7G1	NHL repeat containing 3	ISS			PTHR24104:SF8	NHL REPEAT-CONTAINING PROTEIN 3
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P02757	O-antigen biosynthesis	P03045	dTDP-glucose 4,6-dehydratase	CANLF|Ensembl=ENSCAFG00000005327|UniProtKB=E2QWQ8	Uncharacterized protein	ISS			PTHR43000:SF7	DTDP-D-GLUCOSE 4,6-DEHYDRATASE
P00057	Wnt signaling pathway	P01443	Phospholipase C	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01451	Galpha	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	RAT|RGD=71027|UniProtKB=P42264	Glutamate receptor ionotropic, kainate 3	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00019	Endothelin signaling pathway	P00572	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00011	Blood coagulation	P00458	GP IIIa	MOUSE|MGI=MGI=96612|UniProtKB=O54890	Integrin beta-3	ISS	484963	gi	PTHR10082:SF25	INTEGRIN BETA-3
P05913	Enkephalin release	G06046	preproenkephalin mRNA	BOVIN|Gene=PDYN|UniProtKB=Q95104	Proenkephalin-B	ISS	131330	OMIM	PTHR11438:SF4	PROENKEPHALIN-B
P00052	TGF-beta signaling pathway	G01548	I-SMAD	CANLF|Ensembl=ENSCAFG00000017332|UniProtKB=E2RB30	Mothers against decapentaplegic homolog	ISS	9335505	PubMed	PTHR13703:SF28	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	ISS	11707292	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BOVIN|Gene=ACTB|UniProtKB=P60712	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=1351344|UniProtKB=Q68ED2	Metabotropic glutamate receptor 7	ISS	9407094	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Gene=ADRA1A|UniProtKB=P18130	Alpha-1A adrenergic receptor	IDA			PTHR24248:SF16	ALPHA-1A ADRENERGIC RECEPTOR
P00006	Apoptosis signaling pathway	P00260	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	20331588	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00058	mRNA splicing	P01475	U2AF65	MACMU|Ensembl=ENSMMUG00000014054|UniProtKB=F7AGD2	Uncharacterized protein	ISS			PTHR12620:SF4	ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 5
P02742	Tetrahydrofolate biosynthesis	P02951	GTP cyclohydrolase	BACSU|EnsemblGenome=BSU22780|UniProtKB=P19465	GTP cyclohydrolase 1	ISS			PTHR11109:SF0	GTP CYCLOHYDROLASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1693|UniProtKB=Q6P967	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-7595|UniProtKB=Q6PBR4	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00018	EGF receptor signaling pathway	P00547	PP2A	HUMAN|HGNC=9299|UniProtKB=P67775	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	IGI	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04623	CBP	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	IDA	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05731	GABA-B receptor II signaling	P05752	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04665	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P02746	Heme biosynthesis	P02970	Coproporphyrinogen oxidase (oxygen independent)	MYCTU|EnsemblGenome=Rv2388c|UniProtKB=P9WP73	Oxygen-independent coproporphyrinogen-III oxidase-like protein Rv2388c	ISS			PTHR13932:SF5	OXYGEN-INDEPENDENT COPROPORPHYRINOGEN-III OXIDASE-LIKE PROTEIN YGGW
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00046	Oxidative stress response	P01135	p38	CAEBR|Gene=CBG01555|UniProtKB=A8WRD7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95811|UniProtKB=Q9Z2W8	Glutamate receptor 4	ISS	12941441	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00021	FGF signaling pathway	P00640	PI3K	ARATH|TAIR=AT1G60490|UniProtKB=P42339	Phosphatidylinositol 3-kinase VPS34	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	HUMAN|HGNC=708|UniProtKB=O15511	Actin-related protein 2/3 complex subunit 5	ISS	12473693	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00053	T cell activation	P01336	Jnk	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	RAT|RGD=2736|UniProtKB=P35439	Glutamate receptor ionotropic, NMDA 1	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04374	5HT2 type receptor mediated signaling pathway	P04413	K+ channel	HUMAN|HGNC=6283|UniProtKB=Q9NPC2	Potassium channel subfamily K member 9	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00053	T cell activation	P01294	NFAT	MACMU|Ensembl=ENSMMUG00000003370|UniProtKB=F7E8G2	Uncharacterized protein	ISS	12787506	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	IDA	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00056	VEGF signaling pathway	P01407	Erk	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00648	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IGI	15572354	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00048	PI3 kinase pathway	P01182	Ras	DANRE|ZFIN=ZDB-GENE-040808-67|UniProtKB=Q6AZA4	K-ras	ISS	10825661	PubMed	PTHR24070:SF186	GTPASE KRAS
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00052	TGF-beta signaling pathway	P01292	RSmads	SCHMA|EnsemblGenome=Smp_013060|UniProtKB=Q9GQN9	Mothers against decapentaplegic homolog	TAS			PTHR13703:SF40	PROTEIN MOTHERS AGAINST DPP
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2851|UniProtKB=P35364	5-hydroxytryptamine receptor 5A	IDA	12441358	PubMed	PTHR24247:SF108	5-HYDROXYTRYPTAMINE RECEPTOR 5A
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	CHICK|Ensembl=ENSGALG00000012444|UniProtKB=Q90669	Activin receptor type-2A	TAS	11252892	PubMed	PTHR23255:SF64	ACTIVIN RECEPTOR TYPE-2A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	RCA			PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00020	FAS signaling pathway	P00612	Fas	RAT|RGD=619831|UniProtKB=Q63199	Tumor necrosis factor receptor superfamily member 6	TAS	10327065	PubMed	PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P04395	Vasopressin synthesis	P04589	Signal Peptidase	MOUSE|MGI=MGI=1923469|UniProtKB=Q9D365	Signal peptidase complex subunit 3	IC	2092035	PubMed	PTHR12804:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 3
P00005	Angiogenesis	P00251	cPLA2	MONDO|Ensembl=ENSMODG00000011791|UniProtKB=F7CBU9	Phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00011	Blood coagulation	P00414	Thrombin	MOUSE|MGI=MGI=88380|UniProtKB=P19221	Prothrombin	ISS	+176930	OMIM	PTHR24254:SF10	PROTHROMBIN
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	IC	176892	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P04393	Ras Pathway	P04570	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00629	PP2A	PANTR|Ensembl=ENSPTRG00000004270|UniProtKB=H2Q4R4	Uncharacterized protein	ISS			PTHR10648:SF9	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 65 KDA REGULATORY SUBUNIT A BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00146	Afadin	CANLF|Ensembl=ENSCAFG00000000860|UniProtKB=F1PSU6	Uncharacterized protein	ISS	10974003	PubMed	PTHR10398:SF1	AFADIN
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000016097|UniProtKB=E1B9S9	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	IXOSC|EnsemblGenome=ISCW024111|UniProtKB=B7PBG2	Actin, putative (Fragment)	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00047	PDGF signaling pathway	P01142	p90RSK	RAT|RGD=620683|UniProtKB=P67999	Ribosomal protein S6 kinase beta-1	ISS	11861821	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	MONDO|Ensembl=ENSMODG00000008900|UniProtKB=F7B4C1	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00048	PI3 kinase pathway	P01177	P110ACT	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00035	Interferon-gamma signaling pathway	P00960	PTP	CHICK|Ensembl=ENSGALG00000004821|UniProtKB=Q90687	Tyrosine-protein phosphatase non-receptor type 11	TAS	8096088	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P05731	GABA-B receptor II signaling	P05755	Gbeta	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00036	Interleukin signaling pathway	P00964	p90RSK	RAT|RGD=620676|UniProtKB=F1M7N7	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	MOUSE|MGI=MGI=104742|UniProtKB=P63250	G protein-activated inward rectifier potassium channel 1	ISS	2433589	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00036	Interleukin signaling pathway	P00973	PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CAEEL|WormBase=WBGene00004036|UniProtKB=G5EFI8	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00005	Angiogenesis	P00238	Ras	DICPU|Gene=DICPUDRAFT_91367|UniProtKB=F0ZB76	Putative uncharacterized protein rasD	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	IC	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01018	Glu1	TAKRU|Ensembl=ENSTRUG00000005608|UniProtKB=H2SM93	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	LEIMA|EnsemblGenome=LmjF.35.3960|UniProtKB=E9AFM1	Protein kinase A catalytic subunit isoform 2	ISS	14744463	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000017387|UniProtKB=E2RLD1	Uncharacterized protein	ISS	12507995	PubMed	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00775	Rac	BOVIN|Ensembl=ENSBTAG00000000347|UniProtKB=Q1RMI2	Ras homolog gene family, member G (Rho G)	ISS	4757952	gi	PTHR24072:SF158	RHO-RELATED GTP-BINDING PROTEIN RHOG
P00053	T cell activation	P01297	MEKK	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	RCA	8643568	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00059	p53 pathway	P04630	PP2A	IXOSC|EnsemblGenome=ISCW014549|UniProtKB=B7QGY5	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04371	5-Hydroxytryptamine biosynthesis	P04399	Tryptophan hydroxylase	RAT|RGD=631332|UniProtKB=Q8CGU9	Tryptophan 5-hydroxylase 2	ISS	14597720	PubMed	PTHR11473:SF16	TRYPTOPHAN 5-HYDROXYLASE 2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00018	EGF receptor signaling pathway	P00564	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P06217	Toll pathway-drosophila	P06344	DL	DROME|FlyBase=FBgn0260632|UniProtKB=P15330	Embryonic polarity protein dorsal	TAS	9510254	PubMed	PTHR24169:SF20	DORSAL-RELATED IMMUNITY FACTOR DIF-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00036	Interleukin signaling pathway	P00970	Interleukin	RAT|RGD=2900|UniProtKB=Q08125	Interleukin-5	IC			PTHR45421:SF1	INTERLEUKIN-5
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00001	Adrenaline and noradrenaline biosynthesis	P00061	PNMT	MOUSE|MGI=MGI=97724|UniProtKB=P40935	Phenylethanolamine N-methyltransferase	ISS	12438093	PubMed	PTHR10867:SF18	PHENYLETHANOLAMINE N-METHYLTRANSFERASE
P00029	Huntington disease	P00807	Actin	MOUSE|MGI=MGI=87906|UniProtKB=P63260	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00021	FGF signaling pathway	P00645	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12960248	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MACMU|Ensembl=ENSMMUG00000028733|UniProtKB=F6ZGX8	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF245	RAS-RELATED PROTEIN R-RAS
P00034	Integrin signalling pathway	P00942	Fyn	HUMAN|HGNC=4037|UniProtKB=P06241	Tyrosine-protein kinase Fyn	IPI	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00018	EGF receptor signaling pathway	P00558	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00034	Integrin signalling pathway	P00919	Arf6	PANTR|Ensembl=ENSPTRG00000006324|UniProtKB=H2Q894	ADP-ribosylation factor 6	ISS	11752622	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00013	Cell cycle	P00486	Cyclin B	DROME|FlyBase=FBgn0000405|UniProtKB=P20439	G2/mitotic-specific cyclin-B	IDA	90242399	PubMed	PTHR10177:SF347	G2/MITOTIC-SPECIFIC CYCLIN-B
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	IDA	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00019	Endothelin signaling pathway	P00591	PLCbeta	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	TAKRU|Ensembl=ENSTRUG00000009259|UniProtKB=H2TF39	Uncharacterized protein	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MONDO|Ensembl=ENSMODG00000024440|UniProtKB=F7DJJ2	Muscarinic acetylcholine receptor	ISS	8100450	PubMed	PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CRYNJ|EnsemblGenome=CNA04650|UniProtKB=Q5KP06	Actin	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00005	Angiogenesis	P00248	Ang-1	MONDO|Ensembl=ENSMODG00000005283|UniProtKB=F7E6U7	Uncharacterized protein (Fragment)	ISS	8980223	PubMed	PTHR19143:SF156	ANGIOPOIETIN-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00875	GEF	BOVIN|Ensembl=ENSBTAG00000001498|UniProtKB=Q2KI41	Cytohesin-2	ISS	11747824	PubMed	PTHR43935:SF4	CYTOHESIN-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00912	Arp2/3	RAT|RGD=1311791|UniProtKB=Q4KLF8	Actin-related protein 2/3 complex subunit 5	ISS	12932731	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	BOVIN|Ensembl=ENSBTAG00000011803|UniProtKB=F1MTZ2	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF427	MYOSIN-3
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MONDO|Ensembl=ENSMODG00000004799|UniProtKB=F6VM87	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00012	Cadherin signaling pathway	P00470	F-actin	CHICK|Ensembl=ENSGALG00000011086|UniProtKB=P68139	Actin, alpha skeletal muscle	ISS	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P06959	CCKR signaling map	P07232	CREB1	HUMAN|HGNC=2345|UniProtKB=P16220	Cyclic AMP-responsive element-binding protein 1	RCA	19074642	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00046	Oxidative stress response	P01135	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PHYIT|EnsemblGenome=PITG_15117|UniProtKB=D0NRP9	Actin-like protein	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00006	Apoptosis signaling pathway	P00284	Flip	PANTR|Ensembl=ENSPTRG00000012798|UniProtKB=H2R695	CASP8 and FADD-like apoptosis regulator	ISS	9228018	PubMed	PTHR10454:SF8	CASP8 AND FADD-LIKE APOPTOSIS REGULATOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CHICK|Gene=ACTG2|UniProtKB=P63270	Actin, gamma-enteric smooth muscle	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MOUSE|MGI=MGI=99677|UniProtKB=O88444	Adenylate cyclase type 1	ISS	2491850	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00563	Gab	MOUSE|MGI=MGI=1333854|UniProtKB=Q9Z1S8	GRB2-associated-binding protein 2	IGI	6753932	gi	PTHR12156:SF4	GRB2-ASSOCIATED-BINDING PROTEIN 2
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	IPI	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00010	B cell activation	P00398	IP3R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	IGI	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00057	Wnt signaling pathway	P01440	Cadherin	XENTR|Xenbase=XB-GENE-484592|UniProtKB=F7BE94	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF322	CADHERIN-6
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05918	p38 MAPK pathway	P06031	p38alpha	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	RCA	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00551	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01465	Ggamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00053	T cell activation	P01318	PKC-theta	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	MOUSE|MGI=MGI=102891|UniProtKB=P51829	Adenylate cyclase type 7	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00036	Interleukin signaling pathway	P00973	PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05913	Enkephalin release	P05977	G-Protein (s)	CAEEL|WormBase=WBGene00001745|UniProtKB=Q7KPV0	G protein, Subunit Alpha	IC			PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00057	Wnt signaling pathway	P01451	Galpha	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04398	p53 pathway feedback loops 2	P04665	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00945	Parvin	BOVIN|Ensembl=ENSBTAG00000000700|UniProtKB=F6QTA8	Uncharacterized protein	ISS	11331308	PubMed	PTHR12114:SF6	ALPHA-PARVIN
P00046	Oxidative stress response	P01135	p38	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	TAS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00006	Apoptosis signaling pathway	P00310	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P02757	O-antigen biosynthesis	P03045	dTDP-glucose 4,6-dehydratase	METAC|EnsemblGenome=MA_3779|UniProtKB=Q8TJK5	dTDP-glucose 4,6-dehydratase	ISS			PTHR43000:SF7	DTDP-D-GLUCOSE 4,6-DEHYDRATASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347742|UniProtKB=E9FZ00	Cytoplasmatic actin	ISS	10974003	PubMed	PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00018	EGF receptor signaling pathway	P00558	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00049	Parkinson disease	P01208	Hsp70	CAEEL|WormBase=WBGene00002008|UniProtKB=P20163	Heat shock 70 kDa protein D	IDA	12150907	PubMed	PTHR19375:SF157	HEAT SHOCK 70 KDA PROTEIN D
P00009	Axon guidance mediated by netrin	P00363	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00560	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06766	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	RCA	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00011	Blood coagulation	P00434	FXIa	PANTR|Gene=F9|UniProtKB=Q95ND7	Coagulation factor IX	ISS	14270099	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P00049	Parkinson disease	P01232	CASK	BOVIN|Ensembl=ENSBTAG00000020136|UniProtKB=A5D7B9	CASK protein	ISS	11430913	PubMed	PTHR23122:SF40	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P00057	Wnt signaling pathway	P01443	Phospholipase C	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	CHICK|Ensembl=ENSGALG00000009405|UniProtKB=F1NKF1	Uncharacterized protein	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00021	FGF signaling pathway	P00629	PP2A	BOVIN|Ensembl=ENSBTAG00000000469|UniProtKB=P67774	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00373	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00036	Interleukin signaling pathway	P00970	Interleukin	RAT|RGD=620047|UniProtKB=P17108	Interleukin-2	IC			PTHR45426:SF1	INTERLEUKIN-2
P00011	Blood coagulation	P00414	Thrombin	BOVIN|Ensembl=ENSBTAG00000007148|UniProtKB=P00735	Prothrombin	ISS	163755	gi	PTHR24254:SF10	PROTHROMBIN
P00021	FGF signaling pathway	P00633	Ras	DICDI|dictyBase=DDB_G0293434|UniProtKB=P15064	Ras-like protein rasG	ISS	89128893	PubMed	PTHR24070:SF282	RAS GTPASE-RELATED
P00057	Wnt signaling pathway	P01438	PP2A	MACMU|Ensembl=ENSMMUG00000008205|UniProtKB=F7GWP9	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	ISS	11007767	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	TAKRU|Ensembl=ENSTRUG00000008018|UniProtKB=H2T5N4	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04633	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CAEEL|WormBase=WBGene00000067|UniProtKB=O45815	ACTin	ISS	11889126	PubMed	PTHR11937:SF352	ACTIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CANLF|Ensembl=ENSCAFG00000016020|UniProtKB=O18840	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	NAS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00022	General transcription by RNA polymerase I	P00655	UBF1	MONDO|Ensembl=ENSMODG00000024054|UniProtKB=F7DF94	Uncharacterized protein	ISS			PTHR13711:SF291	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00269	MAPK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000010184|UniProtKB=F6SR09	Uncharacterized protein	ISS			PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04556	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00011	Blood coagulation	P00410	GP IIb	HUMAN|HGNC=6138|UniProtKB=P08514	Integrin alpha-IIb	ISS	386753	gi	PTHR23220:SF73	INTEGRIN ALPHA-IIB
P00035	Interferon-gamma signaling pathway	P00960	PTP	TAKRU|Ensembl=ENSTRUG00000018529|UniProtKB=H2VDZ2	Tyrosine-protein phosphatase non-receptor type	ISS	7681589	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	IPI	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00046	Oxidative stress response	P01135	p38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	TAS	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00990	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00780	Microtubule	PHYPA|Gene=PHYPADRAFT_223212|UniProtKB=Q6TYR5	Beta-tubulin 3	ISS	9454836	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00642	MEK1-2	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00048	PI3 kinase pathway	P01198	FOXO	RAT|RGD=1309196|UniProtKB=D3ZBQ1	Forkhead box O3a (Predicted)	ISS	15031210	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P02784	Tyrosine biosynthesis	P03213	Aromatic amino acid aminotransferase	CAEBR|Gene=CBG07591|UniProtKB=A8X4H6	Protein CBR-TATN-1	ISS			PTHR11751:SF368	TYROSINE AMINOTRANSFERASE
P00005	Angiogenesis	P00221	JNK1	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_127490|UniProtKB=C3XYC5	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00034	Integrin signalling pathway	P00944	Actin	RAT|RGD=1304556|UniProtKB=P63259	Actin, cytoplasmic 2	ISS	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	RAT|RGD=62029|UniProtKB=P02563	Myosin-6	IEP	89264452	PubMed	PTHR13140:SF721	MYOSIN-6
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	ANOGA|EnsemblGenome=AGAP000329|UniProtKB=Q7QF72	AGAP000329-PA	IC	85270494	PubMed	PTHR18945:SF758	NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA3, ISOFORM B
P06587	Nicotine pharmacodynamics pathway	P06604	SLC18A2	BOVIN|Gene=SLC18A2|UniProtKB=Q27963	Synaptic vesicular amine transporter	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CAEBR|Gene=CBG02401|UniProtKB=A8WUE7	Protein CBR-NMR-1	ISS	11554554	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00057	Wnt signaling pathway	P01434	sFRP	HUMAN|HGNC=10779|UniProtKB=Q5T4F7	Secreted frizzled-related protein 5	ISS	9096311	PubMed	PTHR11309:SF46	SECRETED FRIZZLED-RELATED PROTEIN 5
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	MOUSE|MGI=MGI=1202879|UniProtKB=Q924A0	Transcription factor 7-like 2	TAS	11266476	PubMed	PTHR10373:SF32	TRANSCRIPTION FACTOR 7-LIKE 2
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P04396	Vitamin D metabolism and pathway	P04604	FdxR	CAEEL|WormBase=WBGene00013376|UniProtKB=Q9U1X0	NADPH:adrenodoxin oxidoreductase, mitochondrial	ISS			PTHR11938:SF91	NADPH:ADRENODOXIN OXIDOREDUCTASE, MITOCHONDRIAL
P00052	TGF-beta signaling pathway	P01286	TGFbeta	CHICK|Gene=BMP2|UniProtKB=Q90751	Bone morphogenetic protein 2 (Fragment)	TAS	9759503	PubMed	PTHR11848:SF143	BONE MORPHOGENETIC PROTEIN 2
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02726	Aminobutyrate degradation	P02825	4-aminobutyrate aminotransferase	HUMAN|HGNC=23|UniProtKB=P80404	4-aminobutyrate aminotransferase, mitochondrial	ISS	8133261	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00018	EGF receptor signaling pathway	P00557	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05913	Enkephalin release	P05972	PKA	DANRE|ZFIN=ZDB-GENE-040426-2427|UniProtKB=F1Q6C0	Uncharacterized protein (Fragment)	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P02772	Pyruvate metabolism	P03138	Malate Dehydrogenase	BACSU|EnsemblGenome=BSU12320|UniProtKB=O34736	Uncharacterized oxidoreductase YjmC	ISS	9384377	PubMed	PTHR11091:SF0	SUBFAMILY NOT NAMED
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	ISS	91298951	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01159	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00059	p53 pathway	P01486	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00029	Huntington disease	G01532	PolyQ HTT	MOUSE|MGI=MGI=96067|UniProtKB=P42859	Huntingtin	TAS	9462744	PubMed	PTHR10170:SF10	HUNTINGTIN
P00037	Ionotropic glutamate receptor pathway	P01023	CaMKII	MONDO|Ensembl=ENSMODG00000005317|UniProtKB=F7D2P3	Uncharacterized protein	ISS	12888804	PubMed	PTHR43940:SF4	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT DELTA
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04566	Stat 1/3	RAT|RGD=3772|UniProtKB=P52631	Signal transducer and activator of transcription 3	IDA	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	TAS	7937853	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00045	Notch signaling pathway	P01120	NIcs	MACMU|Ensembl=ENSMMUG00000013637|UniProtKB=F7GL52	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00047	PDGF signaling pathway	P01151	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PANTR|Ensembl=ENSPTRG00000008991|UniProtKB=H2QCN0	Myosin ID	ISS			PTHR13140:SF417	UNCONVENTIONAL MYOSIN-ID
P00052	TGF-beta signaling pathway	P01275	P38	CAEBR|Gene=CBG01555|UniProtKB=A8WRD7	Mitogen-activated protein kinase	ISS	11703092	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00020	FAS signaling pathway	P00615	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00645	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00050	Plasminogen activating cascade	P01254	pro-MMP-13	MACMU|Ensembl=ENSMMUG00000004253|UniProtKB=F6YQ28	Uncharacterized protein	ISS	Fang,Y.,Kitchell,B.E.,Paria,B.andBalkin,R.	free text	PTHR10201:SF165	COLLAGENASE 3
P04393	Ras Pathway	P04547	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	PANTR|Ensembl=ENSPTRG00000008768|UniProtKB=H2QC98	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF368	MYOSIN-8
P00012	Cadherin signaling pathway	P00462	Casein kinase II	MOUSE|MGI=MGI=88543|UniProtKB=Q60737	Casein kinase II subunit alpha	ISS	10617630	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00059	p53 pathway	P04633	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00048	PI3 kinase pathway	P01192	p110	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04566	Stat 1/3	RAT|RGD=3772|UniProtKB=P52631	Signal transducer and activator of transcription 3	IDA	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00029	Huntington disease	P00786	ARF	HUMAN|HGNC=692|UniProtKB=P40616	ADP-ribosylation factor-like protein 1	IPI	11752622	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	DANRE|Ensembl=ENSDARG00000070511|UniProtKB=E7F5R2	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF282	GLUTAMATE RECEPTOR-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	ISS	10799299	PubMed	PTHR10048:SF14	PI-3 KINASE
P00018	EGF receptor signaling pathway	P00562	p38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00048	PI3 kinase pathway	P01199	Galpha	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	IC	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04393	Ras Pathway	P04558	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IDA	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00004	Alzheimer disease-presenilin pathway	P00144	Ire-1	RAT|RGD=1308743|UniProtKB=D3ZTI7	Endoplasmic reticulum (ER) to nucleus signalling 2 (Predicted)	ISS	10619423	PubMed	PTHR13954:SF15	SERINE/THREONINE-PROTEIN KINASE/ENDORIBONUCLEASE IRE2
P00009	Axon guidance mediated by netrin	P00366	Rac	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS	12606638	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MACMU|Ensembl=ENSMMUG00000009771|UniProtKB=F6ZHU6	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF681	MYOSIN-4
P00008	Axon guidance mediated by Slit/Robo	P00346	Sdf1	BOVIN|Ensembl=ENSBTAG00000005077|UniProtKB=Q0P5I9	CXCL12 protein	ISS			PTHR18837:SF3	STROMAL CELL-DERIVED FACTOR 1
P00005	Angiogenesis	P00243	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00056	VEGF signaling pathway	P01409	cPLA2	MONDO|Ensembl=ENSMODG00000011791|UniProtKB=F7CBU9	Phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P02776	Serine glycine biosynthesis	P03160	Phosphoglycerate dehydrogenase	ARATH|TAIR=AT4G34200|UniProtKB=O49485	D-3-phosphoglycerate dehydrogenase 1, chloroplastic	ISS			PTHR42938:SF14	D-3-PHOSPHOGLYCERATE DEHYDROGENASE 1, CHLOROPLASTIC-RELATED
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00029	Huntington disease	P00775	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12874273	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00001	Adrenaline and noradrenaline biosynthesis	P00071	VAT1	PANTR|Ensembl=ENSPTRG00000020039|UniProtKB=H2R9W1	Uncharacterized protein	ISS	12135927	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00036	Interleukin signaling pathway	P00965	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	PHYPA|Gene=PHYPADRAFT_170404|UniProtKB=A9TJC3	Predicted protein	ISS			PTHR23073:SF8	26S PROTEASE REGULATORY SUBUNIT 6B
P00049	Parkinson disease	P01236	Casein kinase II	NEUCR|EnsemblGenome=EFNCRG00000005497|UniProtKB=Q8TG12	Casein kinase II subunit beta-1	IDA	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00005	Angiogenesis	P00203	Erk	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00030	Hypoxia response via HIF activation	P00819	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	TAS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04375	5HT3 type receptor mediated signaling pathway	P04425	K+ channel	DANRE|ZFIN=ZDB-GENE-040724-171|UniProtKB=Q5TZ59	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00057	Wnt signaling pathway	P01446	Calcineurin	BOVIN|Ensembl=ENSBTAG00000010619|UniProtKB=P63099	Calcineurin subunit B type 1	ISS	12015605	PubMed	PTHR23056:SF43	CALCINEURIN SUBUNIT B TYPE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	7937853	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00053	T cell activation	P01333	cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IDA	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00053	T cell activation	P01311	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	IEA	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00010	B cell activation	P00398	IP3R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00034	Integrin signalling pathway	P00932	FAK	MONDO|Ensembl=ENSMODG00000015932|UniProtKB=F6Z395	Uncharacterized protein	ISS	10753828	PubMed	PTHR24418:SF94	PROTEIN-TYROSINE KINASE 2-BETA
P00029	Huntington disease	P00790	beta-Tubulin	TAKRU|Ensembl=ENSTRUG00000005446|UniProtKB=H2SKZ5	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P06587	Nicotine pharmacodynamics pathway	P06604	SLC18A2	MACMU|Ensembl=ENSMMUG00000014817|UniProtKB=F6VXD8	Uncharacterized protein	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00047	PDGF signaling pathway	P01148	Grb2	PANTR|Ensembl=ENSPTRG00000004115|UniProtKB=H2R3E1	GRB2-associated binding protein 2	ISS			PTHR12156:SF4	GRB2-ASSOCIATED-BINDING PROTEIN 2
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	HUMAN|HGNC=1392|UniProtKB=Q15878	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	14507926	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00029	Huntington disease	P00786	ARF	RAT|RGD=621279|UniProtKB=P62332	ADP-ribosylation factor 6	ISS	12932731	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00049	Parkinson disease	P01227	20S proteasome	MONDO|Ensembl=ENSMODG00000016692|UniProtKB=F6WS89	Proteasome subunit alpha type (Fragment)	ISS	12859888	PubMed	PTHR11599:SF40	PROTEASOME SUBUNIT ALPHA TYPE-7
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8672|UniProtKB=Q9UN73	Protocadherin alpha-6	IDA	8120095	PubMed	PTHR24028:SF231	PROTOCADHERIN ALPHA-6
P04396	Vitamin D metabolism and pathway	P04606	VDR	XENTR|Xenbase=XB-GENE-486505|UniProtKB=F7B2T2	Uncharacterized protein	ISS	11705326	PubMed	PTHR24082:SF38	VITAMIN D3 RECEPTOR
P00053	T cell activation	P01311	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8705|UniProtKB=Q9Y5G6	Protocadherin gamma-A7	IDA	8120095	PubMed	PTHR24028:SF56	PROTOCADHERIN GAMMA-A7
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00551	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	ARATH|TAIR=AT5G44340|UniProtKB=P24636	Tubulin beta-4 chain	ISS	12932731	PubMed	PTHR11588:SF245	TUBULIN BETA-4 CHAIN-RELATED
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95814|UniProtKB=Q60934	Glutamate receptor ionotropic, kainate 1	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	MACMU|Ensembl=ENSMMUG00000018272|UniProtKB=F7HEB8	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	XENTR|Xenbase=XB-GENE-487200|UniProtKB=Q28GC2	Catenin (Cadherin associated protein), beta 1, 88kDa	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MOUSE|MGI=MGI=2183924|UniProtKB=Q8K3H5	Myosin-IIIa	ISS			PTHR13140:SF387	MYOSIN-IIIA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00057	Wnt signaling pathway	P01451	Galpha	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00029	Huntington disease	P00799	JNK-2	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05915	Opioid proenkephalin pathway	P05994	G-protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00036	Interleukin signaling pathway	P00981	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00010	B cell activation	P00386	Calcineurin	PANTR|Ensembl=ENSPTRG00000002631|UniProtKB=H2Q237	Serine/threonine-protein phosphatase	ISS	7532676	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01177	P110ACT	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05918	p38 MAPK pathway	P06020	p38delta	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00006	Apoptosis signaling pathway	P00260	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00060	Ubiquitin proteasome pathway	P01491	E2	MONDO|Ensembl=ENSMODG00000014209|UniProtKB=F6TQE0	Uncharacterized protein	ISS			PTHR43898:SF6	UBIQUITIN-CONJUGATING ENZYME E2 B
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	MACMU|Ensembl=ENSMMUG00000021715|UniProtKB=F7EWA2	Transcription initiation factor TFIID subunit 11	ISS			PTHR13218:SF16	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ORNAN|Ensembl=ENSOANG00000007405|UniProtKB=F7CIV4	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00591	PLCbeta	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00018	EGF receptor signaling pathway	P00565	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	15572354	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00029	Huntington disease	P00778	NMDA receptor	DANRE|ZFIN=ZDB-GENE-051202-2|UniProtKB=Q6ZM67	Uncharacterized protein	ISS	11554554	PubMed	PTHR44391:SF3	SUBFAMILY NOT NAMED
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ORYSJ|EnsemblGenome=OS03G0836000|UniProtKB=Q10AZ4	Actin-3	IDA	10974003	PubMed	PTHR11937:SF254	ACTIN-1-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_188187|UniProtKB=E9GJ31	Guanine nucleotide binding protein, q polypeptide	ISS	1333286	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	MOUSE|MGI=MGI=1919519|UniProtKB=P56389	Cytidine deaminase	ISS			PTHR11644:SF2	CYTIDINE DEAMINASE
P00020	FAS signaling pathway	P00615	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05916	Opioid prodynorphin pathway	P06002	G-protein	XENTR|Xenbase=XB-GENE-6050844|UniProtKB=F6WNJ9	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00017	DNA replication	P00530	Top	DROME|FlyBase=FBgn0003732|UniProtKB=P15348	DNA topoisomerase 2	RCA			PTHR10169:SF38	DNA TOPOISOMERASE 2
P00025	Hedgehog signaling pathway	P00692	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00034	Integrin signalling pathway	P00936	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	HUMAN|HGNC=4587|UniProtKB=Q14957	Glutamate receptor ionotropic, NMDA 2C	IC	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DICDI|dictyBase=DDB_G0283907|UniProtKB=P34099	cAMP-dependent protein kinase catalytic subunit	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P05734	Synaptic vesicle trafficking	P05776	RIM1alpha/2alpha	CHICK|Ensembl=ENSGALG00000016074|UniProtKB=F1P092	Uncharacterized protein	ISS			PTHR12157:SF15	REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN 2
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	MOUSE|MGI=MGI=98299|UniProtKB=P50431	Serine hydroxymethyltransferase, cytosolic	ISS			PTHR11680:SF21	SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC
P00021	FGF signaling pathway	P00623	FGF	MACMU|Ensembl=ENSMMUG00000015527|UniProtKB=F6RWC6	Fibroblast growth factor	ISS	11286634	PubMed	PTHR11486:SF21	FIBROBLAST GROWTH FACTOR 10
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00005	Angiogenesis	P00196	VRAP	MACMU|Ensembl=ENSMMUG00000010917|UniProtKB=F7GLS8	Uncharacterized protein	ISS	Q9NP31	SPACC	PTHR14388:SF9	SH2 DOMAIN-CONTAINING PROTEIN 2A
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00012	Cadherin signaling pathway	P00467	alpha-catenin	HUMAN|HGNC=2509|UniProtKB=P35221	Catenin alpha-1	ISS	10456847	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	CAEEL|WormBase=WBGene00001172|UniProtKB=G5ECN9	Prohormone convertase 2	IDA			PTHR42884:SF13	NEUROENDOCRINE CONVERTASE 2
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00019	Endothelin signaling pathway	P00577	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P02741	Flavin biosynthesis	P02939	Lumazine synthase	METAC|EnsemblGenome=MA_1818|UniProtKB=Q8TPT7	6,7-dimethyl-8-ribityllumazine synthase	ISS			PTHR21058:SF0	6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE
P00059	p53 pathway	P04633	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	MOUSE|MGI=MGI=106217|UniProtKB=Q61290	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	8386525	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00057	Wnt signaling pathway	P01458	Protein Kinase C	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT2G43790|UniProtKB=Q39026	Mitogen-activated protein kinase 6	ISS	12787066	PubMed	PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P04393	Ras Pathway	P04542	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00790	beta-Tubulin	DANRE|ZFIN=ZDB-GENE-031110-4|UniProtKB=Q6NW90	Tubulin, beta 5	ISS	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00034	Integrin signalling pathway	P00942	Fyn	MACMU|Ensembl=ENSMMUG00000017017|UniProtKB=F7FVL2	Tyrosine-protein kinase	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00004	Alzheimer disease-presenilin pathway	P00167	CD44 transmembrane fragment	HUMAN|HGNC=1681|UniProtKB=P16070	CD44 antigen	IDA	14871815	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02772	Pyruvate metabolism	P03133	Pyruvate Dehydrogenase	ORYSJ|EnsemblGenome=OS02G0739600|UniProtKB=Q6Z5N4	Pyruvate dehydrogenase E1 component subunit alpha-1, mitochondrial	ISS	9952460	PubMed	PTHR11516:SF40	PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01284	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000005909|UniProtKB=H2Q7M1	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF46	PROTOCADHERIN-8
P00018	EGF receptor signaling pathway	P00560	Raf-1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01194	S6K	CANLF|Ensembl=ENSCAFG00000011590|UniProtKB=E2R7K9	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00018	EGF receptor signaling pathway	P00550	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	8235613	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00020	FAS signaling pathway	P00603	Pro-Caspase9	PANTR|Ensembl=ENSPTRG00000000200|UniProtKB=H2PY35	Caspase	ISS	9390557	PubMed	PTHR10454:SF157	CASPASE-9
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CANLF|Ensembl=ENSCAFG00000028654|UniProtKB=J9P702	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	8925912	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	IDA	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	MOUSE|MGI=MGI=98728|UniProtKB=Q64729	TGF-beta receptor type-1	IDA			PTHR23255:SF61	TGF-BETA RECEPTOR TYPE-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	ANOGA|EnsemblGenome=AGAP010750|UniProtKB=Q7PMK5	AGAP010750-PA	ISS	15858232	PubMed	PTHR13715:SF79	RYANODINE RECEPTOR
P00049	Parkinson disease	P01208	Hsp70	XENTR|Xenbase=XB-GENE-480060|UniProtKB=F6UZ27	Uncharacterized protein	ISS	10934466	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00030	Hypoxia response via HIF activation	P00825	Thioredoxin	PLAF7|EnsemblGenome=PF14_0545|UniProtKB=Q7KQL8	Thioredoxin	ISS			PTHR10438:SF360	THIOREDOXIN H9-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	MACMU|Ensembl=ENSMMUG00000012005|UniProtKB=F7H091	Metabotropic glutamate receptor 2 isoform a	ISS	12488551	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00021	FGF signaling pathway	P00632	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IGI	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000020425|UniProtKB=H2QWF6	Uncharacterized protein	ISS	8120095	PubMed	PTHR44603:SF2	CADHERIN-17
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01307	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00049	Parkinson disease	P01219	SAPK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	DANRE|ZFIN=ZDB-GENE-040625-167|UniProtKB=Q6IQP4	RAP1A, member of RAS oncogene family	ISS	10476970	PubMed	PTHR24070:SF284	RAP1A, MEMBER OF RAS ONCOGENE FAMILY
P00057	Wnt signaling pathway	P01435	SWI/SNF	HUMAN|HGNC=26956|UniProtKB=Q9ULG1	DNA helicase INO80	ISS	11532957	PubMed	PTHR10799:SF868	DNA HELICASE INO80
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	CANLF|Ensembl=ENSCAFG00000003715|UniProtKB=F1PFQ5	Uncharacterized protein	ISS	12356903	PubMed	PTHR11514:SF3	N-MYC PROTO-ONCOGENE PROTEIN
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	DICPU|Gene=DICPUDRAFT_91367|UniProtKB=F0ZB76	Putative uncharacterized protein rasD	ISS	6091907	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00034	Integrin signalling pathway	P00920	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00053	T cell activation	P01336	Jnk	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	BOVIN|Ensembl=ENSBTAG00000016797|UniProtKB=A7MB90	CSNK1G2 protein	ISS	11437445	PubMed	PTHR11909:SF157	CASEIN KINASE I ISOFORM GAMMA-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00048	PI3 kinase pathway	P01185	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00057	Wnt signaling pathway	P01435	SWI/SNF	MACMU|Ensembl=ENSMMUG00000008818|UniProtKB=F7F0X3	Putative global transcription activator SNF2L1 isoform a	ISS	11532957	PubMed	PTHR10799:SF819	GLOBAL TRANSCRIPTION ACTIVATOR SNF2L1-RELATED
P02785	Valine biosynthesis	P03216	Acetolactate synthase	MOUSE|MGI=MGI=1351911|UniProtKB=Q8BU33	Acetolactate synthase-like protein	ISS			PTHR18968:SF155	ACETOLACTATE SYNTHASE-LIKE PROTEIN
P00029	Huntington disease	P00780	Microtubule	PANTR|Ensembl=ENSPTRG00000027750|UniProtKB=H2QS82	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00049	Parkinson disease	P01238	14-3-3	MONDO|Ensembl=ENSMODG00000013658|UniProtKB=F6TY10	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00004	Alzheimer disease-presenilin pathway	P00147	TACE	BOVIN|Ensembl=ENSBTAG00000001141|UniProtKB=G3MZB3	Uncharacterized protein	ISS	12834808	PubMed	PTHR11905:SF171	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17
P00030	Hypoxia response via HIF activation	P00819	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00790	beta-Tubulin	CAEBR|Gene=CBG20196|UniProtKB=A8XX81	Protein CBR-TBB-2	ISS	9454836	PubMed	PTHR11588:SF84	TUBULIN BETA-2 CHAIN
P00034	Integrin signalling pathway	P00912	Arp2/3	BOVIN|Ensembl=ENSBTAG00000046248|UniProtKB=Q58CQ2	Actin-related protein 2/3 complex subunit 1B	IPI	12473693	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P06587	Nicotine pharmacodynamics pathway	P06605	KCNK3/9	HUMAN|HGNC=6278|UniProtKB=O14649	Potassium channel subfamily K member 3	RCA	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MACMU|Ensembl=ENSMMUG00000005238|UniProtKB=F7BWT2	Uncharacterized protein	ISS			PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00050	Plasminogen activating cascade	P01250	MMP-13	RAT|RGD=620196|UniProtKB=P23097	Collagenase 3 (Fragment)	ISS	91093077	PubMed	PTHR10201:SF165	COLLAGENASE 3
P00054	Toll receptor signaling pathway	P01375	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IC	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IDA	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	BOVIN|Ensembl=ENSBTAG00000015670|UniProtKB=E1B7J7	Uncharacterized protein	ISS	7559398	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05752	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	RAT|RGD=3852|UniProtKB=P80204	TGF-beta receptor type-1	TAS	10683140	PubMed	PTHR23255:SF61	TGF-BETA RECEPTOR TYPE-1
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00034	Integrin signalling pathway	P00945	Parvin	PANTR|Ensembl=ENSPTRG00000003373|UniProtKB=H2Q373	Uncharacterized protein	ISS	11331308	PubMed	PTHR12114:SF6	ALPHA-PARVIN
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014262|UniProtKB=F7BYS8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00005	Angiogenesis	P00203	Erk	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00035	Interferon-gamma signaling pathway	P00960	PTP	DANRE|ZFIN=ZDB-GENE-030131-5911|UniProtKB=F1QZU5	Tyrosine-protein phosphatase non-receptor type	ISS	14534538	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00013	Cell cycle	P00480	Proteasome	SCHPO|PomBase=SPBC4C3.07|UniProtKB=O43060	Eukaryotic translation initiation factor 3 subunit F	ISS	21848401	PubMed	PTHR10540:SF6	EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DICDI|dictyBase=DDB_G0279605|UniProtKB=P34148	Rho-related protein racB	ISS	12932731	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00010	B cell activation	P00401	jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00029	Huntington disease	P00799	JNK-2	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00053	T cell activation	P01322	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00018	EGF receptor signaling pathway	P00542	EGFR	ORNAN|Ensembl=ENSOANG00000007021|UniProtKB=F7GAV2	Receptor protein-tyrosine kinase	ISS	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00036	Interleukin signaling pathway	P00990	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05754	Ggamma	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	RCA	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04393	Ras Pathway	P04547	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P00057	Wnt signaling pathway	P01438	PP2A	SCHMA|EnsemblGenome=Smp_165490|UniProtKB=C1LZY9	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00759	PDEalphabeta	BOVIN|Gene=PDE6A|UniProtKB=P11541	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	ISS	P27664	SPACC	PTHR11347:SF115	ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01447	Dishevelled	CANLF|Ensembl=ENSCAFG00000016066|UniProtKB=E2R7K2	Uncharacterized protein	ISS	11212302	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	HUMAN|HGNC=9509|UniProtKB=P49810	Presenilin-2	IDA	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	XENTR|Xenbase=XB-GENE-963560|UniProtKB=Q0VFC4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00021	FGF signaling pathway	P00642	MEK1-2	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IGI	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00056	VEGF signaling pathway	P01425	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00539	14-3-3	IXOSC|EnsemblGenome=ISCW011376|UniProtKB=B7Q5I4	Multifunctional chaperone, putative	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	XENTR|Xenbase=XB-GENE-483455|UniProtKB=Q0IHM5	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05754	Ggamma	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00021	FGF signaling pathway	P00627	ERK1-2	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00321	HSP70	PANTR|Ensembl=ENSPTRG00000004404|UniProtKB=H2Q500	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF239	HEAT SHOCK COGNATE 71 KDA PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00865	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	BOVIN|Ensembl=ENSBTAG00000008026|UniProtKB=P01175	Oxytocin-neurophysin 1	ISS	9756087	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00018	EGF receptor signaling pathway	P00560	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00011	Blood coagulation	P00406	Fibrinogen	HUMAN|HGNC=3661|UniProtKB=P02671	Fibrinogen alpha chain	ISS	6575700	PubMed	PTHR19143:SF232	FIBRINOGEN ALPHA CHAIN
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	ISS	91072385	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	PANTR|Ensembl=ENSPTRG00000010386|UniProtKB=H2QF61	Tyrosine-protein kinase receptor	ISS	2983222	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	HUMAN|HGNC=7166|UniProtKB=P08253	72 kDa type IV collagenase	TAS	12834808	PubMed	PTHR10201:SF29	72 KDA TYPE IV COLLAGENASE
P00054	Toll receptor signaling pathway	P01354	NFkappaB	MACMU|Ensembl=ENSMMUG00000007418|UniProtKB=F6QZH6	Uncharacterized protein	ISS	10049353	PubMed	PTHR24169:SF1	TRANSCRIPTION FACTOR P65
P00010	B cell activation	P00371	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00642	MEK1-2	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	15572354	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00048	PI3 kinase pathway	P01199	Galpha	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00591	PLCbeta	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00021	FGF signaling pathway	P00643	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PUCGT|EnsemblGenome=PGTG_05488|UniProtKB=E3K4I1	Actin	IC	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04398	p53 pathway feedback loops 2	P04657	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	DICDI|dictyBase=DDB_G0282365|UniProtKB=P34146	Rho-related protein rac1C	ISS			PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00005	Angiogenesis	P00236	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MOUSE|MGI=MGI=107861|UniProtKB=Q7TMM9	Tubulin beta-2A chain	ISS	12932731	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P00011	Blood coagulation	P00443	Fibrin polymer cross-linked	BOVIN|Gene=FGB|UniProtKB=P02676	Fibrinogen beta chain	ISS			PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00056	VEGF signaling pathway	P01412	HSP27	CHICK|Ensembl=ENSGALG00000007945|UniProtKB=Q05713	Alpha-crystallin B chain	ISS			PTHR11527:SF37	ALPHA-CRYSTALLIN B CHAIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00048	PI3 kinase pathway	P01196	PDK1	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P06664	Gonadotropin-releasing hormone receptor pathway	G06688	LHbeta	MOUSE|MGI=MGI=96782|UniProtKB=O09108	Lutropin subunit beta	RCA			PTHR11515:SF11	LUTROPIN SUBUNIT BETA
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	XENTR|Xenbase=XB-GENE-493902|UniProtKB=F6R0B7	Uncharacterized protein (Fragment)	ISS			PTHR10937:SF2	GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE  ISOMERIZING  1
P00047	PDGF signaling pathway	P01163	c-Jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000003236|UniProtKB=F7DNS6	Uncharacterized protein	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P05913	Enkephalin release	P05977	G-Protein (s)	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00018	EGF receptor signaling pathway	P00552	Ras	MOUSE|MGI=MGI=1100856|UniProtKB=O08989	Ras-related protein M-Ras	ISS			PTHR24070:SF268	RAS-RELATED PROTEIN M-RAS
P00010	B cell activation	P00398	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MACMU|Ensembl=ENSMMUG00000014245|UniProtKB=F7C4E6	Uncharacterized protein	ISS	11841575	PubMed	PTHR43893:SF5	HISTAMINE H2 RECEPTOR
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00005	Angiogenesis	P00244	MAPKAPK2/3	HUMAN|HGNC=6887|UniProtKB=P49137	MAP kinase-activated protein kinase 2	ISS	9628873	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00029	Huntington disease	P00805	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00006	Apoptosis signaling pathway	P00302	ATF	CHICK|Ensembl=ENSGALG00000010322|UniProtKB=E1C7D8	Uncharacterized protein	ISS			PTHR23351:SF10	JUN DIMERIZATION PROTEIN 2
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00010	B cell activation	P00371	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00514	MLCK	HUMAN|HGNC=16243|UniProtKB=Q9H1R3	Myosin light chain kinase 2, skeletal/cardiac muscle	TAS	11157482	PubMed	PTHR45210:SF1	MYOSIN LIGHT CHAIN KINASE 2, SKELETAL/CARDIAC MUSCLE
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=2685045|UniProtKB=E9QAN8	Protein Pik3c2b	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00898	FKHR	HUMAN|HGNC=3819|UniProtKB=Q12778	Forkhead box protein O1	TAS			PTHR11829:SF159	FORKHEAD BOX PROTEIN O1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IDA	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05731	GABA-B receptor II signaling	P05755	Gbeta	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04567	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04564	MAPKAP	BOVIN|Ensembl=ENSBTAG00000038107|UniProtKB=F1MCX5	Uncharacterized protein	ISS	8262198	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00054	Toll receptor signaling pathway	P01344	TRIF	HUMAN|HGNC=21354|UniProtKB=Q86XR7	TIR domain-containing adapter molecule 2	IDA	22716271	PubMed	PTHR22811:SF75	TIR DOMAIN-CONTAINING ADAPTER MOLECULE 2
P00034	Integrin signalling pathway	P00941	Integrin alpha	MOUSE|MGI=MGI=96601|UniProtKB=Q9QUM0	Integrin alpha-IIb	IPI	3487386	PubMed	PTHR23220:SF73	INTEGRIN ALPHA-IIB
P06664	Gonadotropin-releasing hormone receptor pathway	G06689	Atf3	MOUSE|MGI=MGI=109384|UniProtKB=Q60765	Cyclic AMP-dependent transcription factor ATF-3	RCA	11390664	PubMed	PTHR23351:SF23	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-3
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00025	Hedgehog signaling pathway	P00692	GSK3	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00034	Integrin signalling pathway	P00927	Rac	DROME|FlyBase=FBgn0010333|UniProtKB=P40792	Ras-related protein Rac1	IGI	8649368	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00020	FAS signaling pathway	P00620	CytochromeC	TRYB2|Gene=Tb927.8.1890|UniProtKB=D6XKS6	Cytochrome c1, heme protein, mitochondrial	ISS	15163634	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00005	Angiogenesis	P00203	Erk	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00912	Arp2/3	MACMU|Ensembl=ENSMMUG00000006492|UniProtKB=F7H998	Actin-related protein 2/3 complex subunit 3	ISS	12473693	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	ISS	14684598	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00034	Integrin signalling pathway	P00907	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04578	Rho	XENTR|Xenbase=XB-GENE-1019548|UniProtKB=Q28IJ0	Novel Rho protein	ISS	10556059	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00010	B cell activation	P00371	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05917	Opioid proopiomelanocortin pathway	P06009	K+ channel	MACMU|Ensembl=ENSMMUG00000005826|UniProtKB=F6VE51	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00059	p53 pathway	P01486	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04658	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P02722	Acetate utilization	P02802	Phosphate acetyltransferase	THEMA|EnsemblGenome=TM_1755|UniProtKB=Q9X277	Phosphate butyryltransferase	ISS			PTHR43356:SF2	SUBFAMILY NOT NAMED
P00059	p53 pathway	P04609	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	129387	gi	PTHR10048:SF14	PI-3 KINASE
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	ORYSJ|EnsemblGenome=OS02G0797500|UniProtKB=Q6KAJ2	Aspartate aminotransferase	ISS			PTHR11879:SF1	ASPARTATE AMINOTRANSFERASE, CYTOPLASMIC
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00020	FAS signaling pathway	P00601	c-Jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	MOUSE|MGI=MGI=95819|UniProtKB=P35438	Glutamate receptor ionotropic, NMDA 1	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_188187|UniProtKB=E9GJ31	Guanine nucleotide binding protein, q polypeptide	ISS	8836152	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00053	T cell activation	P01322	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	TAS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00001	Adrenaline and noradrenaline biosynthesis	P00070	VAT2	BOVIN|Gene=SLC18A2|UniProtKB=Q27963	Synaptic vesicular amine transporter	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04395	Vasopressin synthesis	P04590	Vasopressin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00012	Cadherin signaling pathway	P00474	Wnt	CHICK|Gene=WNT8C|UniProtKB=P51030	Protein Wnt-8c	IDA	11266476	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	BOVIN|Ensembl=ENSBTAG00000018114|UniProtKB=Q28043	Activin receptor type-2A	TAS	11252892	PubMed	PTHR23255:SF64	ACTIVIN RECEPTOR TYPE-2A
P00014	Cholesterol biosynthesis	P00491	Hydroxymethyl glutaryl CoA reductase	MACMU|Ensembl=ENSMMUG00000006139|UniProtKB=F6PRW7	3-hydroxy-3-methylglutaryl coenzyme A reductase	ISS	Q29512	SPACC	PTHR10572:SF2	3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE
P02748	Isoleucine biosynthesis	P02997	Acetolactate synthase	METJA|EnsemblGenome=MJ_0663|UniProtKB=Q58077	Uncharacterized protein MJ0663	ISS			PTHR18968:SF13	ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05912	Dopamine receptor mediated signaling pathway	P05962	DAT	MACMU|Ensembl=ENSMMUG00000005198|UniProtKB=Q7JHP9	Transporter	ISS	15135042	PubMed	PTHR11616:SF38	SODIUM-DEPENDENT DOPAMINE TRANSPORTER
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=109168|UniProtKB=F2Z4A3	Protein Fat1	IDA	8120095	PubMed	PTHR24026:SF42	PROTOCADHERIN FAT 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01312	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05726	2-arachidonoylglycerol biosynthesis	P05735	PLA1	PANTR|Ensembl=ENSPTRG00000015702|UniProtKB=H2R0M0	Uncharacterized protein	ISS			PTHR11610:SF12	LIPASE MEMBER H
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00053	T cell activation	P01300	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04397	p53 pathway by glucose deprivation	P04636	S6K	MACMU|Ensembl=ENSMMUG00000019305|UniProtKB=F6S3T8	Ribosomal protein S6 kinase	ISS	15116068	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00056	VEGF signaling pathway	P01411	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P02781	Threonine biosynthesis	P03190	Threonine synthase	BOVIN|Ensembl=ENSBTAG00000009117|UniProtKB=F1MBE1	Uncharacterized protein	ISS			PTHR43515:SF1	THREONINE SYNTHASE-LIKE 1
P00054	Toll receptor signaling pathway	P01375	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=2136754|UniProtKB=Q91VD8	MCG141290	IDA	8120095	PubMed	PTHR24028:SF71	PROTOCADHERIN BETA-16
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00045	Notch signaling pathway	P01119	NIct	MACMU|Ensembl=ENSMMUG00000013637|UniProtKB=F7GL52	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00018	EGF receptor signaling pathway	P00565	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IGI	3045562	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	IDA	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CANLF|Ensembl=ENSCAFG00000016635|UniProtKB=F1P7L9	Uncharacterized protein	ISS			PTHR13140:SF341	UNCONVENTIONAL MYOSIN-IE
P00006	Apoptosis signaling pathway	P00321	HSP70	DROME|FlyBase=FBgn0051354|UniProtKB=Q9VG58	Major heat shock 70 kDa protein Bbb	ISS	12150907	PubMed	PTHR19375:SF256	HSP70 PROTEIN-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	MOUSE|MGI=MGI=1276116|UniProtKB=B2RWS6	Histone acetyltransferase p300	ISS			PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00029	Huntington disease	P00774	Dynein complex	RAT|RGD=621798|UniProtKB=Q63170	Dynein heavy chain 7, axonemal	ISS	9454836	PubMed	PTHR10676:SF310	DYNEIN HEAVY CHAIN 7, AXONEMAL
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00036	Interleukin signaling pathway	P00966	mTOR	CHICK|Ensembl=ENSGALG00000003339|UniProtKB=F1NUX4	Uncharacterized protein	ISS	8662507	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	TAS	12855688	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-2555|UniProtKB=F8W3G9	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P04393	Ras Pathway	P04542	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	IGI	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	TAS	3045562	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	MOUSE|MGI=MGI=1933206|UniProtKB=A2AIR5	Protein Grin3a	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00053	T cell activation	P01332	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00017	DNA replication	P00527	Histones	STRPU|EnsemblGenome=SPU_014711|UniProtKB=H3IYA6	Histone H3	ISS	12413958	PubMed	PTHR11426:SF20	HISTONE H3-LIKE CENTROMERIC PROTEIN A
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	IPI	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00036	Interleukin signaling pathway	P00968	Ikk	MACMU|Ensembl=ENSMMUG00000008351|UniProtKB=F7HRV5	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	MOUSE|MGI=MGI=94926|UniProtKB=P51436	D(4) dopamine receptor	ISS	11861492	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	RAT|RGD=2025|UniProtKB=P68136	Actin, alpha skeletal muscle	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00005	Angiogenesis	P00240	FRS-2	XENTR|Xenbase=XB-GENE-479760|UniProtKB=B5DE89	Frs2 protein	ISS	21384985	PubMed	PTHR21258:SF40	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00018	EGF receptor signaling pathway	P00546	GAP	PANTR|Ensembl=ENSPTRG00000015472|UniProtKB=H2QNH9	Uncharacterized protein	ISS	20475167	gi	PTHR10194:SF21	RAS GTPASE-ACTIVATING PROTEIN 2
P00010	B cell activation	P00373	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	RAT|RGD=68399|UniProtKB=Q925B4	Synaptotagmin-8	RCA			PTHR10024:SF249	SYNAPTOTAGMIN-8
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IGI	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	TAS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00010	B cell activation	P00381	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00564	Rac	ENTHI|EnsemblGenome=EHI_129750|UniProtKB=C4M5Q7	Rho family GTPase	IGI	8649368	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P04372	5-Hydroxytryptamine degredation	P04401	Monoamine Oxidase	PANTR|Ensembl=ENSPTRG00000034260|UniProtKB=H2RBI0	Uncharacterized protein	ISS			PTHR10742:SF21	L-AMINO-ACID OXIDASE
P00041	Metabotropic glutamate receptor group I pathway	P01062	mGluR1	RAT|RGD=2746|UniProtKB=P31424	Metabotropic glutamate receptor 5	ISS			PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P04393	Ras Pathway	P04553	PAK	RAT|RGD=3251|UniProtKB=Q62829	Serine/threonine-protein kinase PAK 3	IDA	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00048	PI3 kinase pathway	P01189	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00018	EGF receptor signaling pathway	P00539	14-3-3	MACMU|Ensembl=ENSMMUG00000004125|UniProtKB=F6XLR8	14-3-3 protein gamma	ISS	10407019	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00029	Huntington disease	P00813	SH3GL3	PANTR|Ensembl=ENSPTRG00000007393|UniProtKB=H2QA01	Uncharacterized protein	ISS	12932731	PubMed	PTHR43965:SF4	ENDOPHILIN-A3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01063	CAT	HUMAN|HGNC=1912|UniProtKB=P28329	Choline O-acetyltransferase	IC	92155737	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MOUSE|MGI=MGI=1346876|UniProtKB=O35099	Mitogen-activated protein kinase kinase kinase 5	ISS	8974401	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CAEEL|WormBase=WBGene00004045|UniProtKB=Q8IA75	Phosphoinositide phospholipase C	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P00021	FGF signaling pathway	P00641	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	15860573	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04542	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00208	MEKK1	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00551	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IGI	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00790	beta-Tubulin	PANTR|Ensembl=ENSPTRG00000017674|UniProtKB=H2Q189	Uncharacterized protein	TAS	12932731	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00049	Parkinson disease	P01211	ERK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	HUMAN|HGNC=129|UniProtKB=P68133	Actin, alpha skeletal muscle	IC	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	CHICK|Ensembl=ENSGALG00000012894|UniProtKB=P30372	Muscarinic acetylcholine receptor M2	ISS	10069496	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CAEBR|Gene=CBG02167|UniProtKB=A8WS37	Protein CBG02167	ISS	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05918	p38 MAPK pathway	P06016	HSP27	RAT|RGD=61306|UniProtKB=P42930	Heat shock protein beta-1	ISS			PTHR11527:SF114	HEAT SHOCK PROTEIN BETA-1
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_79607|UniProtKB=C3ZHN4	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00030	Hypoxia response via HIF activation	P00819	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8681|UniProtKB=Q9UN67	Protocadherin beta-10	IDA	8120095	PubMed	PTHR24028:SF54	PROTOCADHERIN BETA-10
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT1G01560|UniProtKB=Q9LMM5	Mitogen-activated protein kinase 11	ISS	11707292	PubMed	PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	IC	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CAEBR|Gene=CBG23090|UniProtKB=A8Y4R0	Protein CBG23090	ISS	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P04392	P53 pathway feedback loops 1	P04537	p73DeltaN	PANTR|Ensembl=ENSPTRG00000015733|UniProtKB=H2QNY5	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00048	PI3 kinase pathway	P01187	IR	RAT|RGD=2917|UniProtKB=P15127	Insulin receptor	IDA	2983222	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	RCA	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00925	MEK	MACMU|Ensembl=ENSMMUG00000019842|UniProtKB=F7FU91	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	TAKRU|Ensembl=ENSTRUG00000015938|UniProtKB=H2UUX5	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00045	Notch signaling pathway	P01118	Numb	CANLF|Ensembl=ENSCAFG00000016834|UniProtKB=F6UX21	Uncharacterized protein	ISS	10468633	PubMed	PTHR11232:SF33	PROTEIN NUMB HOMOLOG
P05913	Enkephalin release	P05974	G-Protein (i)	DICPU|Gene=DICPUDRAFT_93216|UniProtKB=F1A421	Guanine nucleotide-binding protein subunit beta	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00572	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00045	Notch signaling pathway	P01112	CoR	MACMU|Ensembl=ENSMMUG00000023006|UniProtKB=F6TI63	Uncharacterized protein	ISS	11112321	PubMed	PTHR13151:SF2	COREPRESSOR INTERACTING WITH RBPJ 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000006999|UniProtKB=E1BDQ4	Uncharacterized protein	ISS	15226293	PubMed	PTHR13715:SF15	RYANODINE RECEPTOR 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF330	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04547	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00029	Huntington disease	P00790	beta-Tubulin	BOVIN|Ensembl=ENSBTAG00000004093|UniProtKB=Q6B856	Tubulin beta-2B chain	ISS	9454836	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01095	beta	HUMAN|HGNC=1962|UniProtKB=P17787	Neuronal acetylcholine receptor subunit beta-2	ISS	22213672	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P00059	p53 pathway	P04623	CBP	CAEEL|WormBase=WBGene00009595|UniProtKB=Q7JMS5	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	HUMAN|HGNC=10484|UniProtKB=Q92736	Ryanodine receptor 2	ISS	8930069	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00019	Endothelin signaling pathway	P00581	Guanylate cyclase	MOUSE|MGI=MGI=2660877|UniProtKB=F8VQK3	Protein Gucy1a2	RCA			PTHR11920:SF276	GUANYLATE CYCLASE SOLUBLE SUBUNIT ALPHA-2
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	ARATH|TAIR=AT3G55940|UniProtKB=Q9LY51	Phosphoinositide phospholipase C 7	TAS			PTHR10336:SF92	PHOSPHOINOSITIDE PHOSPHOLIPASE C 2-RELATED
P00021	FGF signaling pathway	P00637	MKK4,7	PANTR|Ensembl=ENSPTRG00000008783|UniProtKB=H2QCA7	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00025	Hedgehog signaling pathway	P00699	Su(fu)	PANTR|Ensembl=ENSPTRG00000002895|UniProtKB=H2Q2H8	Suppressor of fused homolog	ISS	12068298	PubMed	PTHR10928:SF2	SUPPRESSOR OF FUSED HOMOLOG
P04393	Ras Pathway	P04570	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	ARATH|TAIR=AT4G35290|UniProtKB=Q93YT1	Glutamate receptor 3.2	IC	12871085	PubMed	PTHR43891:SF18	GLUTAMATE RECEPTOR 3.1-RELATED
P05913	Enkephalin release	P05972	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P02756	N-acetylglucosamine metabolism	P03041	Glucosamine-6-phosphate deaminase	XENTR|Xenbase=XB-GENE-966376|UniProtKB=F7B2V6	Glucosamine-6-phosphate isomerase	ISS			PTHR11280:SF8	GLUCOSAMINE-6-PHOSPHATE ISOMERASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	TAS	96009592	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	XENTR|Xenbase=XB-GENE-492636|UniProtKB=F7D1A1	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00034	Integrin signalling pathway	P00916	Ras	TAKRU|Ensembl=ENSTRUG00000005329|UniProtKB=H2SK54	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P04397	p53 pathway by glucose deprivation	P04641	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	MONDO|Ensembl=ENSMODG00000023174|UniProtKB=F7D7P2	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF197	CALMODULIN-LIKE PROTEIN 3
P00034	Integrin signalling pathway	P00925	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	IDA	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IGI	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	RAT|RGD=620142|UniProtKB=Q9JLB5	Neuronal acetylcholine receptor subunit alpha-10	IC			PTHR18945:SF768	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-10
P00057	Wnt signaling pathway	P01465	Ggamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00014	Cholesterol biosynthesis	P00491	Hydroxymethyl glutaryl CoA reductase	CANLF|Ensembl=ENSCAFG00000009517|UniProtKB=E2R9Z3	3-hydroxy-3-methylglutaryl coenzyme A reductase	ISS	Q29512	SPACC	PTHR10572:SF2	3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	10514528	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	HUMAN|HGNC=1389|UniProtKB=Q00975	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	11976940	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000007576|UniProtKB=H2QA92	Uncharacterized protein	ISS	12181435	PubMed	PTHR24229:SF20	SOMATOSTATIN RECEPTOR TYPE 5
P00020	FAS signaling pathway	P00601	c-Jun	CHICK|Gene=JUN|UniProtKB=P18870	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00054	Toll receptor signaling pathway	P01375	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00021	FGF signaling pathway	P00642	MEK1-2	CAEEL|WormBase=WBGene00003186|UniProtKB=Q10664	Dual specificity mitogen-activated protein kinase kinase mek-2	IGI	22022015	PubMed	PTHR24361:SF629	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	15737619	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00018	EGF receptor signaling pathway	P00558	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MOUSE|MGI=MGI=96799|UniProtKB=P10166	Protein L-Myc	IEP	12356903	PubMed	PTHR11514:SF1	PROTEIN L-MYC-RELATED
P02741	Flavin biosynthesis	P02934	Riboflavin kinase	HUMAN|HGNC=30324|UniProtKB=Q969G6	Riboflavin kinase	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P00053	T cell activation	P01300	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04398	p53 pathway feedback loops 2	P04661	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	96009592	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00056	VEGF signaling pathway	P01413	PI3K	XENTR|Xenbase=XB-GENE-6067221|UniProtKB=F6Z0J4	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04393	Ras Pathway	P04569	Cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	HUMAN|HGNC=6696|UniProtKB=O75096	Low-density lipoprotein receptor-related protein 4	IDA	11907044	PubMed	PTHR44017:SF4	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4
P00056	VEGF signaling pathway	P01404	SPK	RAT|RGD=1307757|UniProtKB=Q6AYB2	Protein Sphk2	ISS			PTHR12358:SF40	SPHINGOSINE KINASE 2
P00029	Huntington disease	P00780	Microtubule	MACMU|Ensembl=ENSMMUG00000029059|UniProtKB=F6QAX2	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00053	T cell activation	P01306	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	3035212	PubMed	PTHR24070:SF385	GTPASE HRAS
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_125401|UniProtKB=C3ZTX6	Putative uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	TAS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05731	GABA-B receptor II signaling	P05760	AC	MACMU|Ensembl=ENSMMUG00000010440|UniProtKB=F7CRV6	Uncharacterized protein	ISS	12890691	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00476	Yes	PANTR|Ensembl=ENSPTRG00000009824|UniProtKB=H2QE70	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF90	TYROSINE-PROTEIN KINASE YES
P02749	Leucine biosynthesis	P03001	3-Isopropylmalate dehydrogenase	THEMA|EnsemblGenome=TM_0556|UniProtKB=Q9WZ26	3-isopropylmalate dehydrogenase	ISS			PTHR42979:SF1	3-ISOPROPYLMALATE DEHYDROGENASE
P02752	Mannose metabolism	P03017	Mannose 6-P isomerase	YEAST|SGD=S000000805|UniProtKB=P29952	Mannose-6-phosphate isomerase	IDA	8011630	PubMed	PTHR10309:SF0	MANNOSE-6-PHOSPHATE ISOMERASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00059	p53 pathway	P01485	p53	CHICK|Ensembl=ENSGALG00000007324|UniProtKB=F1N8Z7	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P06664	Gonadotropin-releasing hormone receptor pathway	P06772	Tubulin	MOUSE|MGI=MGI=107804|UniProtKB=P05213	Tubulin alpha-1B chain	RCA			PTHR11588:SF251	TUBULIN ALPHA-1B CHAIN
P00052	TGF-beta signaling pathway	P01286	TGFbeta	CHICK|Ensembl=ENSGALG00000027613|UniProtKB=Q6Q247	Growth differentiation factor 9	TAS	9759503	PubMed	PTHR11848:SF19	GROWTH/DIFFERENTIATION FACTOR 9
P00012	Cadherin signaling pathway	P00470	F-actin	RAT|RGD=628837|UniProtKB=P60711	Actin, cytoplasmic 1	IC	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00047	PDGF signaling pathway	P01160	IP3 receptor	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00018	EGF receptor signaling pathway	P00547	PP2A	RAT|RGD=6503701|UniProtKB=F1MAA3	Protein LOC100909464	ISS	10092233	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01284	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	TAS	10514528	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2522|UniProtKB=P30729	D(4) dopamine receptor	IDA	1319557	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00019	Endothelin signaling pathway	P00589	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P06002	G-protein	CAEEL|WormBase=WBGene00001648|UniProtKB=P51875	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P05915	Opioid proenkephalin pathway	P05991	Enkephalin	MOUSE|MGI=MGI=104629|UniProtKB=P22005	Proenkephalin-A	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P02784	Tyrosine biosynthesis	P03214	Prephenate dehydrogenase	STRCO|Gene=CAB38592|UniProtKB=Q9Z4W3	Putative oxidoreductase	ISS			PTHR21363:SF0	PREPHENATE DEHYDROGENASE  NADP +
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	TAS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00021	FGF signaling pathway	P00648	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	ARATH|TAIR=AT1G13890|UniProtKB=Q9LMG8	Putative SNAP25 homologous protein SNAP30	IC			PTHR19305:SF7	SNAP25 HOMOLOGOUS PROTEIN SNAP30-RELATED
P00036	Interleukin signaling pathway	P00990	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00539	14-3-3	ORNAN|Ensembl=ENSOANG00000003572|UniProtKB=F7DGH9	Uncharacterized protein	ISS	6756037	gi	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00629	PP2A	ARATH|TAIR=AT5G44090|UniProtKB=Q9XGR4	Serine/threonine protein phosphatase 2A regulatory subunit B''alpha	ISS			PTHR14095:SF0	SERINE/THREONINE PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B''ALPHA-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000009389|UniProtKB=F7HEV7	Uncharacterized protein	ISS	11259498	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P02741	Flavin biosynthesis	P02933	Pyrimidine deaminase	BACTN|EnsemblGenome=BT_3728|UniProtKB=Q8A1D8	Riboflavin biosynthesis protein RibD	ISS			PTHR44288:SF1	RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBD
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00029	Huntington disease	P00805	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00018	EGF receptor signaling pathway	P00551	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IGI	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00812	Caspase 3	CANLF|Ensembl=ENSCAFG00000007750|UniProtKB=Q8MKI5	Caspase-3	IDA	11675509	PubMed	PTHR10454:SF198	CASPASE-3
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MOUSE|MGI=MGI=1351338|UniProtKB=P97772	Metabotropic glutamate receptor 1	IDA	8314195	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DICDI|dictyBase=DDB_G0268622|UniProtKB=P34145	Rho-related protein rac1B	ISS	8649368	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	PRIPA|Gene=PPA22610|UniProtKB=H3FK05	Uncharacterized protein	ISS			PTHR24072:SF192	CDC42 HOMOLOG
P00054	Toll receptor signaling pathway	P01358	ERK1	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02738	De novo purine biosynthesis	P02902	ADP reductase	HALSA|EnsemblGenome=VNG_2383G|UniProtKB=Q9HMU4	Ribonucleoside reductase small chain	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MACMU|Ensembl=ENSMMUG00000009341|UniProtKB=F6UA54	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P04397	p53 pathway by glucose deprivation	P04641	Akt	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	ISS	21291563	gi	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00235	c-Fos	CANLF|Ensembl=ENSCAFG00000017040|UniProtKB=E2QYK5	Uncharacterized protein	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00012	Cadherin signaling pathway	P00470	F-actin	SCHMA|EnsemblGenome=Smp_161920|UniProtKB=G4VSW5	Putative actin	IC	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P02726	Aminobutyrate degradation	P02824	Succinate semi-aldehyde dehydrogenase	DROME|FlyBase=FBgn0039349|UniProtKB=Q9VBP6	GH21316p	ISS	12891648	PubMed	PTHR43353:SF5	SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00006	Apoptosis signaling pathway	P00310	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	TAS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	RAT|RGD=2342|UniProtKB=P08482	Muscarinic acetylcholine receptor M1	ISS	11166329	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	MYCTU|EnsemblGenome=Rv1384|UniProtKB=P9WPK3	Carbamoyl-phosphate synthase large chain	ISS			PTHR11405:SF5	CAD PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=2683547|UniProtKB=Q4KWH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1	ISS	12860966	PubMed	PTHR10336:SF51	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00036	Interleukin signaling pathway	P00996	STAT	MACMU|Ensembl=ENSMMUG00000017527|UniProtKB=F6UMM2	Signal transducer and activator of transcription	ISS	94367369	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00029	Huntington disease	P00780	Microtubule	PANTR|Ensembl=ENSPTRG00000010369|UniProtKB=H2QF52	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF253	TUBULIN BETA-4A CHAIN
P05917	Opioid proopiomelanocortin pathway	P06011	AC	RAT|RGD=619965|UniProtKB=P26769	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00036	Interleukin signaling pathway	P00970	Interleukin	PANTR|Ensembl=ENSPTRG00000016154|UniProtKB=H2QPN2	C-X-C motif chemokine	ISS	124361	gi	PTHR10179:SF70	INTERLEUKIN-8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00049	Parkinson disease	P01211	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	IC	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00644	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00047	PDGF signaling pathway	P01173	STAT	MACMU|Ensembl=ENSMMUG00000000803|UniProtKB=F6R1P6	Signal transducer and activator of transcription	ISS			PTHR11801:SF41	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 2
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	CANLF|Ensembl=ENSCAFG00000004119|UniProtKB=F1PQA5	Uncharacterized protein	ISS	11988536	PubMed	PTHR10126:SF20	TATA-BOX-BINDING PROTEIN
P00053	T cell activation	P01312	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00020	FAS signaling pathway	P00615	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	PANTR|Ensembl=ENSPTRG00000006698|UniProtKB=H2Q8W1	Bradykinin receptor B2	ISS	12130679	PubMed	PTHR24228:SF25	B2 BRADYKININ RECEPTOR
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	CHICK|Ensembl=ENSGALG00000015176|UniProtKB=F1NU41	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00021	FGF signaling pathway	P00648	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	DANRE|ZFIN=ZDB-GENE-020125-5|UniProtKB=A2CG69	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF356	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	8687404	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	DROME|FlyBase=FBgn0011291|UniProtKB=P49906	Transcription initiation factor TFIID subunit 11	ISS			PTHR13218:SF8	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	TAS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00049	Parkinson disease	P01211	ERK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	IDA	9836510	gi	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02776	Serine glycine biosynthesis	P03157	Phosphoserine aminotransferase	MOUSE|MGI=MGI=2183441|UniProtKB=Q99K85	Phosphoserine aminotransferase	ISS	20886743	gi	PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P00047	PDGF signaling pathway	P01168	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	12660731	PubMed	PTHR10048:SF14	PI-3 KINASE
P05918	p38 MAPK pathway	P06021	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	CAEEL|WormBase=WBGene00010759|UniProtKB=O45679	Bifunctional L-3-cyanoalanine synthase/cysteine synthase	ISS			PTHR10314:SF81	BIFUNCTIONAL L-3-CYANOALANINE SYNTHASE/CYSTEINE SYNTHASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	IC	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00052	TGF-beta signaling pathway	P01275	P38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	TAS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01458	Protein Kinase C	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01238	14-3-3	MONDO|Ensembl=ENSMODG00000010174|UniProtKB=F6TA21	Uncharacterized protein	ISS	5803225	gi	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014262|UniProtKB=F7BYS8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	ISS	10477300	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P02723	Adenine and hypoxanthine salvage pathway	P02813	Inosine phosphorylase	CAEBR|Gene=CBG13501|UniProtKB=A8XI15	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00057	Wnt signaling pathway	P01444	Wnt	BOVIN|Ensembl=ENSBTAG00000005570|UniProtKB=E1BKL2	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	IDA	9836510	gi	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P02752	Mannose metabolism	P03017	Mannose 6-P isomerase	ARATH|TAIR=AT1G67070|UniProtKB=Q9FZH5	Mannose-6-phosphate isomerase 2	TAS	15219821	gi	PTHR10309:SF0	MANNOSE-6-PHOSPHATE ISOMERASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05916	Opioid prodynorphin pathway	P06002	G-protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00589	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00371	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00029	Huntington disease	G01535	PIG3	ECOLI|EcoGene=EG11492|UniProtKB=P28304	Quinone oxidoreductase 1	TAS	12932731	PubMed	PTHR42975:SF1	QUINONE OXIDOREDUCTASE-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	DROME|FlyBase=FBgn0266137|UniProtKB=Q24563	Dopamine receptor 2	IDA	11861492	PubMed	PTHR24248:SF56	DOPAMINE RECEPTOR 2
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	HUMAN|HGNC=1951|UniProtKB=P08172	Muscarinic acetylcholine receptor M2	TAS	8100450	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MONDO|Ensembl=ENSMODG00000004799|UniProtKB=F6VM87	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P02771	Pyrimidine Metabolism	P03129	Aminotransferase	YEAST|SGD=S000003251|UniProtKB=P17649	4-aminobutyrate aminotransferase	ISS	8133261	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	NAS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00012	Cadherin signaling pathway	P00470	F-actin	CHICK|Ensembl=ENSGALG00000014620|UniProtKB=F1N8P3	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	IC	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04393	Ras Pathway	P04578	Rho	BOVIN|Ensembl=ENSBTAG00000014299|UniProtKB=Q1RMJ6	Rho-related GTP-binding protein RhoC	ISS	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04393	Ras Pathway	P04559	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00048	PI3 kinase pathway	P01182	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MOUSE|MGI=MGI=1096327|UniProtKB=O35625	Axin-1	ISS	12356903	PubMed	PTHR10845:SF11	AXIN-1
P04393	Ras Pathway	P04543	MEKK1/4	BOVIN|Ensembl=ENSBTAG00000020079|UniProtKB=F1N3T0	Uncharacterized protein	ISS	12878610	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00015	Circadian clock system	G01501	cry	RAT|RGD=620935|UniProtKB=Q923I8	Cryptochrome-2	IEP	10428031	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	MOUSE|MGI=MGI=1920014|UniProtKB=Q8BVP5	Casein kinase I isoform gamma-2	ISS	11437445	PubMed	PTHR11909:SF157	CASEIN KINASE I ISOFORM GAMMA-2
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00051	TCA cycle	P01266	Pyruvate Dehydrogenase	STRCO|Gene=CAB99150|UniProtKB=Q9K3H0	Putative pyruvate dehydrogenase alpha subunit	ISS	21219778	gi	PTHR11516:SF2	SUBFAMILY NOT NAMED
P00010	B cell activation	P00391	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g242065|UniProtKB=A7S0V7	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04392	P53 pathway feedback loops 1	G04686	p73	HUMAN|HGNC=12003|UniProtKB=O15350	Tumor protein p73	ISS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00001	Adrenaline and noradrenaline biosynthesis	P00067	MAO	MACMU|Ensembl=ENSMMUG00000019492|UniProtKB=F7D3H3	Amine oxidase [flavin-containing]	ISS	90344230	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P00057	Wnt signaling pathway	P01444	Wnt	BRAFL|Gene=BRAFLDRAFT_271417|UniProtKB=C3ZCG7	Protein Wnt	IDA	11266476	PubMed	PTHR12027:SF102	PROTEIN WNT-4
P00053	T cell activation	P01324	rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05915	Opioid proenkephalin pathway	P05985	Mu or Delta receptor	HUMAN|HGNC=8153|UniProtKB=P41143	Delta-type opioid receptor	RCA	11259487	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00056	VEGF signaling pathway	P01417	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00236	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01428	Frizzled	HUMAN|HGNC=4041|UniProtKB=Q9NPG1	Frizzled-3	IDA	12549854	PubMed	PTHR11309:SF22	FRIZZLED-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000039772|UniProtKB=F6QI78	Uncharacterized protein	ISS			PTHR24247:SF31	5-HYDROXYTRYPTAMINE RECEPTOR 2B
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00019	Endothelin signaling pathway	P00589	Akt	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	IGI	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00364	cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00052	TGF-beta signaling pathway	P01284	JNK	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	TAS	10851062	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00018	EGF receptor signaling pathway	P00547	PP2A	MOUSE|MGI=MGI=1349475|UniProtKB=Q60996	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	ISS	8576224	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P00005	Angiogenesis	P00221	JNK1	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00048	PI3 kinase pathway	P01177	P110ACT	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00058	mRNA splicing	P01476	U4	HUMAN|HGNC=17348|UniProtKB=O43395	U4/U6 small nuclear ribonucleoprotein Prp3	IGI	12875835	PubMed	PTHR14212:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3
P00015	Circadian clock system	P00504	Per	BOVIN|Ensembl=ENSBTAG00000003889|UniProtKB=F1MDK3	Uncharacterized protein	ISS	12782655	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	91298951	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01432	Beta-Catenin	CHICK|Ensembl=ENSGALG00000011905|UniProtKB=F1NHT7	Uncharacterized protein	IDA	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00056	VEGF signaling pathway	P01412	HSP27	RAT|RGD=61306|UniProtKB=P42930	Heat shock protein beta-1	RCA			PTHR11527:SF114	HEAT SHOCK PROTEIN BETA-1
P05913	Enkephalin release	P05972	PKA	LEIMA|EnsemblGenome=LmjF.35.4010|UniProtKB=Q9GNR4	Protein kinase A catalytic subunit isoform 1	ISS	10218114	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00015	Circadian clock system	P00505	Cry	PANTR|Ensembl=ENSPTRG00000003537|UniProtKB=H2Q3H0	Uncharacterized protein	ISS	10428031	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00029	Huntington disease	P00786	ARF	MONDO|Ensembl=ENSMODG00000024451|UniProtKB=F6Z8M9	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF234	ADP-RIBOSYLATION FACTOR 1
P00056	VEGF signaling pathway	P01414	PLC-gamma	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04393	Ras Pathway	P04566	Stat 1/3	MONDO|Ensembl=ENSMODG00000028212|UniProtKB=F7BYN4	Signal transducer and activator of transcription	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P02771	Pyrimidine Metabolism	P03124	Methylmalonate Semialdehyde Dehydrogenase	BACSU|EnsemblGenome=BSU39760|UniProtKB=P42412	Methylmalonate semialdehyde dehydrogenase [acylating]	ISS	9384377	PubMed	PTHR43866:SF4	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00189	Fzd	MONDO|Ensembl=ENSMODG00000008701|UniProtKB=F6PWM3	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF22	FRIZZLED-3
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	HUMAN|HGNC=1952|UniProtKB=P20309	Muscarinic acetylcholine receptor M3	ISS	12915051	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00021	FGF signaling pathway	P00646	RasGAP	DROME|FlyBase=FBgn0003969|UniProtKB=Q8IR23	GH13542p	ISS	7293174	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00007	Axon guidance mediated by semaphorins	P00330	CRAM	ORNAN|Ensembl=ENSOANG00000000514|UniProtKB=F7CVF2	Uncharacterized protein	ISS	11034345	PubMed	PTHR11647:SF58	DIHYDROPYRIMIDINASE-RELATED PROTEIN 5
P00048	PI3 kinase pathway	P01177	P110ACT	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00796	Kainate receptor	XENTR|Xenbase=XB-GENE-957124|UniProtKB=F7BDN8	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P02722	Acetate utilization	P02802	Phosphate acetyltransferase	ECOLI|EcoGene=EG20173|UniProtKB=P0A9M8	Phosphate acetyltransferase	RCA			PTHR43356:SF3	PHOSPHATE ACETYLTRANSFERASE
P02738	De novo purine biosynthesis	P02909	GDP reductase	BACSU|EnsemblGenome=BSU17380|UniProtKB=P50620	Ribonucleoside-diphosphate reductase subunit alpha	ISS			PTHR11573:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00948	Rho	PANTR|Ensembl=ENSPTRG00000040414|UniProtKB=H2RH27	Ras homolog gene family, member B	ISS	13679859	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000018361|UniProtKB=P60020	5-hydroxytryptamine receptor 1B	ISS	12181435	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P00037	Ionotropic glutamate receptor pathway	P01026	KA	HUMAN|HGNC=4583|UniProtKB=Q16478	Glutamate receptor ionotropic, kainate 5	ISS	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P02757	O-antigen biosynthesis	P03045	dTDP-glucose 4,6-dehydratase	METAC|EnsemblGenome=MA_2186|UniProtKB=Q8TNU3	dTDP-glucose 4,6-dehydratase	ISS			PTHR43000:SF7	DTDP-D-GLUCOSE 4,6-DEHYDRATASE
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	MOUSE|MGI=MGI=1276116|UniProtKB=B2RWS6	Histone acetyltransferase p300	ISS	8413673	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00036	Interleukin signaling pathway	P00990	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	TAKRU|Ensembl=ENSTRUG00000007253|UniProtKB=H2SZQ1	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00047	PDGF signaling pathway	P01161	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02730	Asparagine and aspartate biosynthesis	P02853	Asparagine synthetase	BOVIN|Ensembl=ENSBTAG00000003222|UniProtKB=Q1LZA3	Asparagine synthetase [glutamine-hydrolyzing]	ISS			PTHR11772:SF23	ASPARAGINE SYNTHETASE  GLUTAMINE-HYDROLYZING
P00006	Apoptosis signaling pathway	P00321	HSP70	DROME|FlyBase=FBgn0001218|UniProtKB=P29844	Heat shock 70 kDa protein cognate 3	ISS	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00029	Huntington disease	P00775	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	15470041	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00797	p53	MACMU|Ensembl=ENSMMUG00000008639|UniProtKB=P56424	Cellular tumor antigen p53	ISS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00012	Cadherin signaling pathway	P00475	Frizzled	MOUSE|MGI=MGI=108571|UniProtKB=Q9EQD0	Frizzled-5	IDA	8717036	PubMed	PTHR11309:SF126	FRIZZLED-5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	IC	14765990	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	TAKRU|Ensembl=ENSTRUG00000016101|UniProtKB=H2UW32	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00006	Apoptosis signaling pathway	P00314	MKK3	CHICK|Ensembl=ENSGALG00000004735|UniProtKB=F1NHE1	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00048	PI3 kinase pathway	P01202	p85	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00057	Wnt signaling pathway	P01429	Axin	RAT|RGD=69259|UniProtKB=O70240	Axin-2	IDA	12356903	PubMed	PTHR10845:SF103	AXIN-2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00274	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00047	PDGF signaling pathway	P01172	c-Myc	PANTR|Gene=MYC|UniProtKB=P23583	Myc proto-oncogene protein	ISS	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00021	FGF signaling pathway	P00633	Ras	DICDI|dictyBase=DDB_G0283537|UniProtKB=P32254	Ras-like protein rasS	IDA	94119591	PubMed	PTHR24070:SF380	RAS-LIKE PROTEIN RASS
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	HUMAN|HGNC=5467|UniProtKB=P11717	Cation-independent mannose-6-phosphate receptor	TAS	6382022	PubMed	PTHR15071:SF17	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DICDI|dictyBase=DDB_G0275023|UniProtKB=Q553U6	Putative actin-22	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P02746	Heme biosynthesis	P02974	Uroporphyrinogen-III synthase	NEUCR|EnsemblGenome=EFNCRG00000003162|UniProtKB=Q7S4P0	Uroporphyrinogen-III synthase	ISS			PTHR12390:SF0	UROPORPHYRINOGEN-III SYNTHASE
P00060	Ubiquitin proteasome pathway	P01491	E2	MOUSE|MGI=MGI=3644823|UniProtKB=D3YUH6	Protein Ube2d4	ISS			PTHR24068:SF24	UBIQUITIN-CONJUGATING ENZYME E2 D4
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00053	T cell activation	P01331	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IDA	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00629	PP2A	HUMAN|HGNC=9304|UniProtKB=P63151	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform	IGI	11956189	PubMed	PTHR11871:SF2	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	10669416	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	PANTR|Ensembl=ENSPTRG00000003172|UniProtKB=P30410	Insulin	ISS			PTHR11454:SF9	INSULIN-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	HUMAN|HGNC=1950|UniProtKB=P11229	Muscarinic acetylcholine receptor M1	TAS	8100450	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00627	ERK1-2	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00054	Toll receptor signaling pathway	P01369	MKK1	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00005	Angiogenesis	P00243	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	STRCO|Gene=CAB42663|UniProtKB=Q9X8G1	Pyrroline-5-carboxylate reductase	ISS			PTHR11645:SF0	PYRROLINE-5-CARBOXYLATE REDUCTASE
P00049	Parkinson disease	P01237	Complex I	THEMA|EnsemblGenome=TM_0012|UniProtKB=Q9WXM7	NADP-reducing hydrogenase, subunit A	TAS			PTHR43342:SF2	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00774	Dynein complex	HUMAN|HGNC=24596|UniProtKB=Q96FJ2	Dynein light chain 2, cytoplasmic	IPI	9454836	PubMed	PTHR11886:SF35	DYNEIN LIGHT CHAIN 2, CYTOPLASMIC
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P02738	De novo purine biosynthesis	P02899	GMP synthase	SULSO|EnsemblGenome=SSO3232|UniProtKB=Q97TZ8	GMP synthase [glutamine-hydrolyzing] subunit B	ISS			PTHR43418:SF3	SUBFAMILY NOT NAMED
P00049	Parkinson disease	P01227	20S proteasome	BOVIN|Ensembl=ENSBTAG00000017698|UniProtKB=E1BD83	Uncharacterized protein	ISS	12859888	PubMed	PTHR11599:SF47	PROTEASOME SUBUNIT ALPHA TYPE-7-LIKE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	MOUSE|MGI=MGI=99667|UniProtKB=P46096	Synaptotagmin-1	IDA	1840599	PubMed	PTHR10024:SF239	SYNAPTOTAGMIN-1
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00019	Endothelin signaling pathway	P00573	signal peptidase	HUMAN|HGNC=23400|UniProtKB=Q9BY50	Signal peptidase complex catalytic subunit SEC11C	ISS	2092035	PubMed	PTHR10806:SF12	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11C
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01189	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00036	Interleukin signaling pathway	P00985	PDK1/2	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	ISS	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00048	PI3 kinase pathway	P01192	p110	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	ANOGA|EnsemblGenome=AGAP010589|UniProtKB=Q7Q8S4	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF3	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA-RELATED
P00049	Parkinson disease	P01242	Casein kinase I	DROME|FlyBase=FBgn0032650|UniProtKB=Q9VJC2	CG7094	IDA	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8972|UniProtKB=O00750	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00924	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IPI	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01417	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	HUMAN|HGNC=10447|UniProtKB=P10301	Ras-related protein R-Ras	ISS	7997267	PubMed	PTHR24070:SF245	RAS-RELATED PROTEIN R-RAS
P00005	Angiogenesis	P00203	Erk	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01465	Ggamma	DANRE|ZFIN=ZDB-GENE-010705-1|UniProtKB=Q90Z40	Guanine nucleotide-binding protein subunit gamma	IDA	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00047	PDGF signaling pathway	P01168	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00029	Huntington disease	P00777	CBP	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00052	TGF-beta signaling pathway	P01284	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	ENTHI|EnsemblGenome=EHI_181250|UniProtKB=C4M5Z7	Rho family GTPase	ISS	4757952	gi	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00021	FGF signaling pathway	P00645	Rac	CAEEL|WormBase=WBGene00004287|UniProtKB=Q94124	Ras-related protein rac-2	IGI	21571425	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	21244534	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00036	Interleukin signaling pathway	P00981	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00030	Hypoxia response via HIF activation	P00819	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DAPPU|EnsemblGenome=DAPPUDRAFT_59367|UniProtKB=E9H7Z0	Guanine nucleotide-binding protein G(O) subunit alpha 1	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00018	EGF receptor signaling pathway	P00552	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	CANLF|Ensembl=ENSCAFG00000015075|UniProtKB=E2RMU9	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF125	MATRIX METALLOPROTEINASE-20
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	CHLRE|EnsemblGenome=CHLREDRAFT_136895|UniProtKB=A8IW00	Glutamine synthetase	ISS			PTHR20852:SF57	GLUTAMINE SYNTHETASE 2 CYTOPLASMIC
P00030	Hypoxia response via HIF activation	P00824	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01235	Fyn kinase	MACMU|Ensembl=ENSMMUG00000017017|UniProtKB=F7FVL2	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P06959	CCKR signaling map	P07057	B-Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	RCA	15710605	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	TAS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00059	p53 pathway	P01486	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	TAS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00004	Alzheimer disease-presenilin pathway	P00114	actin	SCHPO|PomBase=SPBC32H8.12c|UniProtKB=P10989	Actin	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00006	Apoptosis signaling pathway	P00260	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00048	PI3 kinase pathway	P01179	PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12539654	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00036	Interleukin signaling pathway	P00965	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IC	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IPI	9516481	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00018	EGF receptor signaling pathway	P00565	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00059	p53 pathway	G01575	GADD45	MACMU|Ensembl=ENSMMUG00000006813|UniProtKB=F7GZG4	Cytokine-responsive protein CR6	ISS	10097101	PubMed	PTHR10411:SF4	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 GAMMA
P00048	PI3 kinase pathway	P01187	IR	MOUSE|MGI=MGI=96575|UniProtKB=P15208	Insulin receptor	IDA	14500580	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P00004	Alzheimer disease-presenilin pathway	P00131	HAC1	YEAST|SGD=S000001863|UniProtKB=P41546	Transcriptional activator HAC1	IDA			PTHR22952:SF374	TRANSCRIPTIONAL ACTIVATOR HAC1
P00047	PDGF signaling pathway	P01154	Ras	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02777	Succinate to proprionate conversion	P03163	Methylmalonyl-CoA decarboxylase	IXOSC|EnsemblGenome=ISCW020770|UniProtKB=B7PXQ1	Propionyl-CoA carboxylase, putative (Fragment)	ISS			PTHR43842:SF1	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01018	Glu1	HUMAN|HGNC=4571|UniProtKB=P42261	Glutamate receptor 1	ISS	12871085	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06812	L-type Ca2+	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	RCA	8838325	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00010	B cell activation	P00371	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	BOVIN|Gene=RPS6KB1|UniProtKB=Q6TJY3	Ribosomal protein S6 kinase beta-1	ISS	15116068	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00036	Interleukin signaling pathway	P00977	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P05918	p38 MAPK pathway	P06023	MEF	HUMAN|HGNC=6995|UniProtKB=Q02080	Myocyte-specific enhancer factor 2B	RCA			PTHR11945:SF335	MYOCYTE-SPECIFIC ENHANCER FACTOR 2B-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04586	ProTRH (Pro Thyrotropin-releasing Hormone)	MOUSE|MGI=MGI=98848|UniProtKB=P12656	Thyrotropin subunit beta	ISS			PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P00034	Integrin signalling pathway	P00951	Jnk	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00036	Interleukin signaling pathway	P00965	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00779	TBP	HALSA|EnsemblGenome=AAC82822|UniProtKB=Q48325	TATA-box-binding protein B	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00012	Cadherin signaling pathway	P00463	betacatenin	RAT|RGD=70487|UniProtKB=Q9WU82	Catenin beta-1	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P05731	GABA-B receptor II signaling	P05755	Gbeta	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=108061|UniProtKB=P48614	Protein Wnt-10b	IDA	11266476	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	CAEBR|Gene=CBG_05938|UniProtKB=H8WGV2	Protein CBR-ITR-1, isoform a	ISS	1849282	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P04393	Ras Pathway	P04570	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	MOUSE|MGI=MGI=87995|UniProtKB=Q91Y97	Fructose-bisphosphate aldolase B	ISS	8086469	PubMed	PTHR11627:SF2	FRUCTOSE-BISPHOSPHATE ALDOLASE B
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	DEIRA|EnsemblGenome=DR_0668|UniProtKB=Q9RWK0	Carbamoyl-phosphate synthase large chain	ISS			PTHR11405:SF5	CAD PROTEIN
P00010	B cell activation	P00371	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01453	Ebi	HUMAN|HGNC=18502|UniProtKB=Q9BQ87	F-box-like/WD repeat-containing protein TBL1Y	IDA	11389839	PubMed	PTHR22846:SF50	F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN TBL1Y
P00012	Cadherin signaling pathway	P00463	betacatenin	BOVIN|Ensembl=ENSBTAG00000016420|UniProtKB=Q0VCX4	Catenin beta-1	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00010	B cell activation	P00371	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	MOUSE|MGI=MGI=1339656|UniProtKB=Q61036	Serine/threonine-protein kinase PAK 3	ISS	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000003399|UniProtKB=H2Q383	Phosphoinositide-3-kinase, class 2, alpha polypeptide	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	TAS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00021	FGF signaling pathway	P00642	MEK1-2	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	TAS	9514948	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00005	Angiogenesis	P00203	Erk	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00052	TGF-beta signaling pathway	P01284	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IC	9860142	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00047	PDGF signaling pathway	P01154	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	IC	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MOUSE|MGI=MGI=1921305|UniProtKB=Q8K4S1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	10934033	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P05915	Opioid proenkephalin pathway	P05993	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	IXOSC|EnsemblGenome=ISCW009711|UniProtKB=B7Q3T6	THO complex subunit, putative	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05915	Opioid proenkephalin pathway	P05993	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	ISS	96149441	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	RCA	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Ensembl=ENSCAFG00000001738|UniProtKB=E2RDG9	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	10395542	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	CANLF|Gene=HTR1D|UniProtKB=P11614	5-hydroxytryptamine receptor 1D	IDA			PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P06959	CCKR signaling map	G06989	ODC1	HUMAN|HGNC=8109|UniProtKB=P11926	Ornithine decarboxylase	RCA	9619831	PubMed	PTHR11482:SF42	ORNITHINE DECARBOXYLASE
P00020	FAS signaling pathway	P00600	PARP	ARATH|TAIR=AT4G02390|UniProtKB=Q11207	Poly [ADP-ribose] polymerase 2	TAS	12101391	PubMed	PTHR10459:SF60	POLY  ADP-RIBOSE  POLYMERASE 2
P04386	Histamine H2 receptor mediated signaling pathway	P04489	H2	MOUSE|MGI=MGI=108482|UniProtKB=P97292	Histamine H2 receptor	ISS	11841575	PubMed	PTHR43893:SF5	HISTAMINE H2 RECEPTOR
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00047	PDGF signaling pathway	P01162	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04393	Ras Pathway	P04567	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01323	I kappa B	RAT|RGD=3171|UniProtKB=Q63746	NF-kappa-B inhibitor alpha	ISS	99081292	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00021	FGF signaling pathway	P00644	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00021	FGF signaling pathway	P00637	MKK4,7	CANLF|Ensembl=ENSCAFG00000017851|UniProtKB=F1PBB6	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	TAS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00029	Huntington disease	P00786	ARF	XENTR|Xenbase=XB-GENE-961332|UniProtKB=Q5BJ82	ADP-ribosylation factor-like 1	ISS	12932731	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00018	EGF receptor signaling pathway	P00544	c-Cbl	DROME|FlyBase=FBgn0020224|UniProtKB=Q9VSK2	Cbl long isoform	ISS			PTHR23007:SF11	CBL LONG ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00644	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04374	5HT2 type receptor mediated signaling pathway	P04413	K+ channel	MOUSE|MGI=MGI=1100509|UniProtKB=O35111	Potassium channel subfamily K member 3	ISS	11875121	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00034	Integrin signalling pathway	P00920	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	XENTR|Xenbase=XB-GENE-961282|UniProtKB=Q6DF43	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00376	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	STRCO|Gene=CAB75395|UniProtKB=Q9L1G4	Folylpolyglutamate synthase	ISS			PTHR11136:SF0	DIHYDROFOLATE SYNTHETASE-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00238	Ras	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g247341|UniProtKB=A7STP5	Predicted protein	ISS			PTHR24070:SF385	GTPASE HRAS
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00047	PDGF signaling pathway	P01159	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	ORNAN|Ensembl=ENSOANG00000008907|UniProtKB=F7EDR2	Receptor protein serine/threonine kinase	ISS	10683140	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P00018	EGF receptor signaling pathway	P00545	JNK1-3	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00924	Raf	TAKRU|Ensembl=ENSTRUG00000006611|UniProtKB=H2SV11	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01188	Gbetagamma	IXOSC|EnsemblGenome=ISCW009711|UniProtKB=B7Q3T6	THO complex subunit, putative	ISS	9740024	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04393	Ras Pathway	P04557	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00006	Apoptosis signaling pathway	P00314	MKK3	MONDO|Ensembl=ENSMODG00000001404|UniProtKB=F7BD74	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00045	Notch signaling pathway	P01104	Serrate	CHICK|Ensembl=ENSGALG00000009020|UniProtKB=E1BTW5	Delta-like protein	IEP	8631496	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	RAT|RGD=2060|UniProtKB=P10608	Beta-2 adrenergic receptor	IDA	7669252	PubMed	PTHR24248:SF21	BETA-2 ADRENERGIC RECEPTOR
P06664	Gonadotropin-releasing hormone receptor pathway	G06672	EGR1	MOUSE|MGI=MGI=95295|UniProtKB=P08046	Early growth response protein 1	RCA			PTHR44685:SF1	EARLY GROWTH RESPONSE PROTEIN 1
P00060	Ubiquitin proteasome pathway	P01490	E3	CANLF|Ensembl=ENSCAFG00000015961|UniProtKB=E2R6W9	Uncharacterized protein	ISS			PTHR44020:SF2	UBIQUITIN-CONJUGATING ENZYME E2 K
P00048	PI3 kinase pathway	P01192	p110	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00238	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00036	Interleukin signaling pathway	P00973	PKB	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00777	CBP	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00029	Huntington disease	P00796	Kainate receptor	PANTR|Ensembl=ENSPTRG00000011042|UniProtKB=H2QGF5	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05730	Endogenous cannabinoid signaling	P05743	CB1	TAKRU|Ensembl=ENSTRUG00000007001|UniProtKB=H2SXR0	Uncharacterized protein	ISS	114610	OMIM	PTHR22750:SF47	CANNABINOID RECEPTOR 1
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MYCTU|EnsemblGenome=Rv1625c|UniProtKB=P9WQ35	Adenylate cyclase	ISS			PTHR11920:SF335	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01428	Frizzled	XENTR|Xenbase=XB-GENE-480379|UniProtKB=Q6GL20	Frizzled homolog 10	ISS	11212302	PubMed	PTHR11309:SF86	FRIZZLED-10
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	MOUSE|MGI=MGI=95821|UniProtKB=Q01097	Glutamate receptor ionotropic, NMDA 2B	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00047	PDGF signaling pathway	P01163	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00048	PI3 kinase pathway	P01179	PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANAL|CGD=CAL0003231|UniProtKB=Q5ANK2	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Gene=DRD2|UniProtKB=P60026	D(2) dopamine receptor	ISS	11248120	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P05731	GABA-B receptor II signaling	P05755	Gbeta	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00017	DNA replication	P00535	5' to 3' Exoribonulcease	RAT|RGD=1310218|UniProtKB=D4A914	5'-3' exoribonuclease 2 (Predicted), isoform CRA_a	ISS	7885830	PubMed	PTHR12341:SF41	5'-3' EXORIBONUCLEASE 2
P05913	Enkephalin release	P05977	G-Protein (s)	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00006	Apoptosis signaling pathway	P00317	Fos	CANLF|Ensembl=ENSCAFG00000017040|UniProtKB=E2QYK5	Uncharacterized protein	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00005	Angiogenesis	P00211	GSK3beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00034	Integrin signalling pathway	P00916	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IPI	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CANLF|Ensembl=ENSCAFG00000013148|UniProtKB=Q5R1P3	Glutamate receptor ionotropic, NMDA 2B	IC	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000001384|UniProtKB=F7GL73	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_114535|UniProtKB=C3ZHN2	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01457	GBeta	DICDI|dictyBase=DDB_G0277143|UniProtKB=P36408	Guanine nucleotide-binding protein subunit beta	IDA	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00036	Interleukin signaling pathway	P00973	PKB	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	RAT|RGD=2091|UniProtKB=P09117	Fructose-bisphosphate aldolase C	ISS	2350361	PubMed	PTHR11627:SF3	FRUCTOSE-BISPHOSPHATE ALDOLASE C
P00056	VEGF signaling pathway	P01425	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P06214	GBB signaling pathway	P06298	FUR1	DROME|FlyBase=FBgn0004509|UniProtKB=P26016	Furin-like protease 1, isoforms 1/1-X/2	IEA	7737999	PubMed	PTHR42884:SF3	FURIN-LIKE PROTEASE 1, ISOFORMS 1/1-X/2
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IDA	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	BOVIN|Ensembl=ENSBTAG00000006495|UniProtKB=P11017	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DROME|FlyBase=FBgn0000043|UniProtKB=P02572	Actin-42A	ISS	10974003	PubMed	PTHR11937:SF369	ACTIN-42A
P00005	Angiogenesis	P00182	p38MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000015599|UniProtKB=F1MIA2	Serine/threonine-protein kinase	ISS	11062248	PubMed	PTHR22968:SF12	SERINE/THREONINE-PROTEIN KINASE D2
P00029	Huntington disease	P00780	Microtubule	CIOIN|Ensembl=ENSCING00000006957|UniProtKB=F6SYL0	Uncharacterized protein	ISS			PTHR11588:SF89	TUBULIN BETA-4 CHAIN
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00049	Parkinson disease	P01211	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00011	Blood coagulation	P00427	alpha2-macroglobulin	MOUSE|MGI=MGI=87854|UniProtKB=Q61838	Pregnancy zone protein	ISS	6680608	gi	PTHR11412:SF116	PREGNANCY ZONE PROTEIN
P00029	Huntington disease	P00796	Kainate receptor	MACMU|Ensembl=ENSMMUG00000022347|UniProtKB=F6ZCH5	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00036	Interleukin signaling pathway	P00996	STAT	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	IC	14984365	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00034	Integrin signalling pathway	P00922	Collagen	PANTR|Ensembl=ENSPTRG00000009393|UniProtKB=H2QDE6	Collagen, type I, alpha 2	ISS	10778855	PubMed	PTHR24023:SF569	COLLAGEN ALPHA-1 I  CHAIN
P00047	PDGF signaling pathway	P01153	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	HUMAN|HGNC=707|UniProtKB=P59998	Actin-related protein 2/3 complex subunit 4	IDA	9230079	PubMed	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00034	Integrin signalling pathway	P00906	Rap1	ORNAN|Ensembl=ENSOANG00000005936|UniProtKB=F6PQC9	Uncharacterized protein	ISS	1904317	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000003043|UniProtKB=P63212	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00034	Integrin signalling pathway	P00944	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g242065|UniProtKB=A7S0V7	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MOUSE|MGI=MGI=95822|UniProtKB=Q01098	Glutamate receptor ionotropic, NMDA 2C	IC	11554549	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00047	PDGF signaling pathway	P01145	c-fos	TAKRU|Ensembl=ENSTRUG00000010579|UniProtKB=H2TPU7	Uncharacterized protein	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00796	Kainate receptor	HUMAN|HGNC=4583|UniProtKB=Q16478	Glutamate receptor ionotropic, kainate 5	IDA	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00050	Plasminogen activating cascade	P01255	Plasminogen	MACMU|Gene=PLG|UniProtKB=P12545	Plasminogen	ISS	2318848	PubMed	PTHR24261:SF6	PLASMINOGEN
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	NEUCR|EnsemblGenome=EFNCRG00000001945|UniProtKB=Q8TG11	Casein kinase II subunit beta-2	IDA	10806215	PubMed	PTHR22746:SF10	RAB6A-GEF COMPLEX PARTNER PROTEIN 1
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00047	PDGF signaling pathway	P01154	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P00037	Ionotropic glutamate receptor pathway	P01026	KA	PANTR|Gene=GRIK4|UniProtKB=Q5IS46	Glutamate receptor ionotropic, kainate 4	ISS	12871085	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	ARATH|TAIR=AT5G57015|UniProtKB=Q8VYK9	Casein kinase 1-like protein 12	ISS	11437445	PubMed	PTHR11909:SF298	CASEIN KINASE 1-LIKE PROTEIN 12-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00056	VEGF signaling pathway	P01413	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01305	Calmodulin	ARATH|TAIR=AT3G43810|UniProtKB=P59220	Calmodulin-7	ISS	3885394	PubMed	PTHR23050:SF250	CALMODULIN-7
P00006	Apoptosis signaling pathway	P00269	MAPK	YEAST|SGD=S000003272|UniProtKB=P14681	Mitogen-activated protein kinase KSS1	ISS	10851062	PubMed	PTHR24055:SF338	MITOGEN-ACTIVATED PROTEIN KINASE KSS1
P00034	Integrin signalling pathway	P00925	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	MOUSE|MGI=MGI=2384786|UniProtKB=Q91XE9	Cyclic AMP-responsive element-binding protein 3-like protein 3	ISS	123810	OMIM	PTHR22952:SF98	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 3
P02771	Pyrimidine Metabolism	P03127	Beta-Ureidopropionase	HUMAN|HGNC=16297|UniProtKB=Q9UBR1	Beta-ureidopropionase	IDA	10542323	PubMed	PTHR43674:SF2	BETA-UREIDOPROPIONASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MOUSE|MGI=MGI=104557|UniProtKB=P18654	Ribosomal protein S6 kinase alpha-3	ISS	6755374	gi	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00034	Integrin signalling pathway	P00907	ERK	MONDO|Ensembl=ENSMODG00000001962|UniProtKB=F6V2H6	Uncharacterized protein	ISS	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	CANLF|Ensembl=ENSCAFG00000009812|UniProtKB=E2RIA0	Uncharacterized protein	ISS	2433589	PubMed	PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00049	Parkinson disease	P01227	20S proteasome	HUMAN|HGNC=9534|UniProtKB=P28066	Proteasome subunit alpha type-5	TAS	12859888	PubMed	PTHR11599:SF14	PROTEASOME SUBUNIT ALPHA TYPE-5
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	PANTR|Ensembl=ENSPTRG00000008601|UniProtKB=H2QBY1	Arrestin, beta 2	ISS	12464600	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00054	Toll receptor signaling pathway	P01375	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	18021322	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05731	GABA-B receptor II signaling	P05760	AC	BOVIN|Ensembl=ENSBTAG00000018777|UniProtKB=E1BHU9	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00046	Oxidative stress response	P01136	Elk-1	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	TAS	3183861	gi	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P04395	Vasopressin synthesis	P04590	Vasopressin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CHICK|Ensembl=ENSGALG00000001334|UniProtKB=F1NLV4	Uncharacterized protein	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00019	Endothelin signaling pathway	P00591	PLCbeta	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT1G07880|UniProtKB=Q9LQQ9	Mitogen-activated protein kinase 13	IDA	10851062	PubMed	PTHR24055:SF185	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00012	Cadherin signaling pathway	P00474	Wnt	PANTR|Ensembl=ENSPTRG00000002062|UniProtKB=H2Q194	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=708420|UniProtKB=Q62688	Inactive phospholipase C-like protein 1	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	11832947	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT2G43790|UniProtKB=Q39026	Mitogen-activated protein kinase 6	ISS	10514528	PubMed	PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00047	PDGF signaling pathway	P01150	PKC	MOUSE|MGI=MGI=109211|UniProtKB=Q8BWW9	Serine/threonine-protein kinase N2	ISS	10644715	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00025	Hedgehog signaling pathway	P00688	Hedgehog	CANLF|Ensembl=ENSCAFG00000029968|UniProtKB=J9NYK0	Hedgehog protein	ISS	8896571	PubMed	PTHR11889:SF36	SONIC HEDGEHOG PROTEIN
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	CHICK|Ensembl=ENSGALG00000009927|UniProtKB=Q5ZHX1	Ras-related protein Rap-1b	ISS	10476970	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	HUMAN|HGNC=1974|UniProtKB=O15111	Inhibitor of nuclear factor kappa-B kinase subunit alpha	RCA			PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P02763	Peptidoglycan biosynthesis	P03087	Glutamate racemase	FUSNN|EnsemblGenome=FN1161|UniProtKB=Q8REE6	Glutamate racemase	ISS			PTHR21198:SF2	GLUTAMATE RACEMASE
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	CAEBR|Gene=CBG00986|UniProtKB=A8WP61	Cysteine synthase	ISS			PTHR10314:SF81	BIFUNCTIONAL L-3-CYANOALANINE SYNTHASE/CYSTEINE SYNTHASE
P00010	B cell activation	P00401	jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00035	Interferon-gamma signaling pathway	P00960	PTP	MACMU|Ensembl=ENSMMUG00000013253|UniProtKB=F6ZJD8	Tyrosine-protein phosphatase non-receptor type	ISS	1382983	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DROME|FlyBase=FBgn0010333|UniProtKB=P40792	Ras-related protein Rac1	ISS	95047333	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00021	FGF signaling pathway	P00627	ERK1-2	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01234	GRK	DANRE|ZFIN=ZDB-GENE-030616-382|UniProtKB=B5LZ08	Protein-serine/threonine kinase	ISS	10852916	PubMed	PTHR24355:SF18	PROTEIN-SERINE/THREONINE KINASE
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	TAKRU|Ensembl=ENSTRUG00000009259|UniProtKB=H2TF39	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00021	FGF signaling pathway	P00648	PKC	SCHPO|PomBase=SPBC12D12.04c|UniProtKB=P36583	Protein kinase C-like 2	IGI	125549	gi	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01318	PKC-theta	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00898	FKHR	MOUSE|MGI=MGI=1890077|UniProtKB=Q9R1E0	Forkhead box protein O1	TAS			PTHR11829:SF159	FORKHEAD BOX PROTEIN O1
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00052	TGF-beta signaling pathway	P01275	P38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	TAS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MACMU|Ensembl=ENSMMUG00000009771|UniProtKB=F6ZHU6	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF681	MYOSIN-4
P00036	Interleukin signaling pathway	P00990	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	DROME|FlyBase=FBgn0011743|UniProtKB=P45891	Actin-like protein 53D	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	ISS	12488551	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00021	FGF signaling pathway	P00642	MEK1-2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00059	p53 pathway	P04609	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	ISS	96009592	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00127	APP	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	DANRE|ZFIN=ZDB-GENE-030828-1|UniProtKB=Q6P3L9	Glutamate dehydrogenase 1	ISS			PTHR11606:SF13	GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL
P00047	PDGF signaling pathway	P01149	MNK1/2	MACMU|Ensembl=ENSMMUG00000020162|UniProtKB=F6TJV6	Uncharacterized protein	ISS	11575158	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00020	FAS signaling pathway	P00601	c-Jun	CHICK|Gene=JUN|UniProtKB=P18870	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00380	fos	MONDO|Ensembl=ENSMODG00000005927|UniProtKB=F6WX28	Uncharacterized protein	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00019	Endothelin signaling pathway	P00566	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CAEBR|Gene=CBG02162|UniProtKB=A8WS33	Protein CBG02162	ISS	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	MACMU|Ensembl=ENSMMUG00000020926|UniProtKB=F7H4N5	Uncharacterized protein	ISS			PTHR19957:SF36	SYNTAXIN-2
P00034	Integrin signalling pathway	P00941	Integrin alpha	MOUSE|MGI=MGI=96605|UniProtKB=Q61739	Integrin alpha-6	IPI	3487386	PubMed	PTHR23220:SF9	INTEGRIN ALPHA-6
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04547	Ras	CAEEL|WormBase=WBGene00002335|UniProtKB=P22981	Ras protein let-60	IDA	22022015	PubMed	PTHR24070:SF385	GTPASE HRAS
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00057	Wnt signaling pathway	P01435	SWI/SNF	ORNAN|Ensembl=ENSOANG00000004355|UniProtKB=F6Q910	Uncharacterized protein	ISS	11532957	PubMed	PTHR10799:SF76	TRANSCRIPTION ACTIVATOR BRG1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00005	Angiogenesis	P00256	PLC-gamma	CAEBR|Gene=CBG18715|UniProtKB=A8XTZ1	Phosphoinositide phospholipase C	ISS			PTHR10336:SF91	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04393	Ras Pathway	P04546	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	IDA	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	MONDO|Ensembl=ENSMODG00000014080|UniProtKB=F6R511	Uncharacterized protein (Fragment)	ISS	10617630	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00029	Huntington disease	P00786	ARF	BOVIN|Ensembl=ENSBTAG00000045647|UniProtKB=A5PKG0	ARL4C protein	ISS	12932731	PubMed	PTHR11711:SF119	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 4C
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	BOVIN|Ensembl=ENSBTAG00000047202|UniProtKB=G3N3K3	Uncharacterized protein	ISS	11554554	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	RAT|RGD=3375|UniProtKB=P62138	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit	ISS	8392016	PubMed	PTHR11668:SF377	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-ALPHA CATALYTIC SUBUNIT
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00053	T cell activation	P01322	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00020	FAS signaling pathway	P00599	Caspase3	CHICK|Ensembl=ENSGALG00000010638|UniProtKB=O93417	Caspase-3	IGI	9323209	PubMed	PTHR10454:SF198	CASPASE-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	DANRE|ZFIN=ZDB-GENE-010125-1|UniProtKB=B8JHS2	Uncharacterized protein	IDA	12093103	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00029	Huntington disease	P00811	Arp2/3 complex	DANRE|ZFIN=ZDB-GENE-040116-1|UniProtKB=Q7ZUQ0	Actin related protein 2/3 complex, subunit 1A	ISS	12473693	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	BOVIN|Gene=TUBB6|UniProtKB=Q2HJ81	Tubulin beta-6 chain	ISS	9454836	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00047	PDGF signaling pathway	P01168	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	ISS	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P00019	Endothelin signaling pathway	P00591	PLCbeta	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00023	General transcription regulation	P00664	TFIIH complex	CANLF|Ensembl=ENSCAFG00000009171|UniProtKB=E2RCX0	Uncharacterized protein	ISS			PTHR12856:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 1
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00018	EGF receptor signaling pathway	P00564	Rac	ORYSJ|EnsemblGenome=OS02G0120800|UniProtKB=Q6ZHA3	Rac-like GTP-binding protein 6	ISS	12932731	PubMed	PTHR24072:SF261	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ENTHI|EnsemblGenome=EHI_107290|UniProtKB=B1N2P0	Actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00005	Angiogenesis	P00225	MEK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS			PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CHICK|Ensembl=ENSGALG00000001172|UniProtKB=P19439	Probable glutamate receptor	IC	12778120	PubMed	PTHR18966:SF282	GLUTAMATE RECEPTOR-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000016187|UniProtKB=F1N213	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IC	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	RAT|RGD=1310749|UniProtKB=D3Z9H7	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	ISS	9133421	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00029	Huntington disease	P00774	Dynein complex	XENTR|Xenbase=XB-GENE-854532|UniProtKB=B0BM87	Dynll2 protein	ISS	9454836	PubMed	PTHR11886:SF35	DYNEIN LIGHT CHAIN 2, CYTOPLASMIC
P00018	EGF receptor signaling pathway	P00545	JNK1-3	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P06664	Gonadotropin-releasing hormone receptor pathway	P06847	JNK1/2	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	RCA	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05918	p38 MAPK pathway	P06020	p38delta	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00007	Axon guidance mediated by semaphorins	P00331	PAK	HUMAN|HGNC=8590|UniProtKB=Q13153	Serine/threonine-protein kinase PAK 1	ISS	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	TAS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00036	Interleukin signaling pathway	P00977	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IC	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00094	BACE-1 pro-domain	PANTR|Ensembl=ENSPTRG00000004324|UniProtKB=H2Q4U8	Beta-site APP-cleaving enzyme 1	ISS	10531052	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	HUMAN|HGNC=11837|UniProtKB=Q04724	Transducin-like enhancer protein 1	IDA	9783586	PubMed	PTHR10814:SF23	TRANSDUCIN-LIKE ENHANCER PROTEIN 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02738	De novo purine biosynthesis	P02902	ADP reductase	BACSU|EnsemblGenome=BSU20040|UniProtKB=O30601	SPBc2 prophage-derived ribonucleoside-diphosphate reductase subunit beta	ISS			PTHR23409:SF32	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT BETA
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	CANLF|Ensembl=ENSCAFG00000018564|UniProtKB=E2RHU1	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00010	B cell activation	P00371	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	MOUSE|MGI=MGI=103016|UniProtKB=P62137	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit	ISS	8392016	PubMed	PTHR11668:SF377	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-ALPHA CATALYTIC SUBUNIT
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	HUMAN|HGNC=4584|UniProtKB=Q05586	Glutamate receptor ionotropic, NMDA 1	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2744|UniProtKB=P31422	Metabotropic glutamate receptor 3	IDA	12488551	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05938	RhoA	MONDO|Ensembl=ENSMODG00000012981|UniProtKB=F7CS91	Uncharacterized protein	ISS	11360179	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00021	FGF signaling pathway	P00632	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IGI	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00912	Arp2/3	TAKRU|Ensembl=ENSTRUG00000014419|UniProtKB=H2UIU6	Uncharacterized protein	ISS	12473693	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P05912	Dopamine receptor mediated signaling pathway	P05957	K+ channel	MACMU|Ensembl=ENSMMUG00000005826|UniProtKB=F6VE51	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00037	Ionotropic glutamate receptor pathway	P01026	KA	PANTR|Ensembl=ENSPTRG00000000543|UniProtKB=H2PYN8	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P06664	Gonadotropin-releasing hormone receptor pathway	G06894	c-fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	RCA	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MOUSE|MGI=MGI=102522|UniProtKB=Q8R3Z5	Voltage-dependent L-type calcium channel subunit beta-1	IC	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00056	VEGF signaling pathway	P01402	MEK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS			PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00007	Axon guidance mediated by semaphorins	P00340	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12960248	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00029	Huntington disease	P00786	ARF	MACMU|Ensembl=ENSMMUG00000015642|UniProtKB=F6RLV0	ADP-ribosylation factor 6	ISS	12932731	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	PANTR|Ensembl=ENSPTRG00000009518|UniProtKB=H2QDN0	Mitogen-activated protein kinase kinase kinase 3	ISS	9006902	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00049	Parkinson disease	P01212	p38 MAPK	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	IPI	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00018	EGF receptor signaling pathway	P00561	STAT	MACMU|Ensembl=ENSMMUG00000010707|UniProtKB=F7G8G5	Signal transducer and activator of transcription	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00020	FAS signaling pathway	P00603	Pro-Caspase9	PANTR|Ensembl=ENSPTRG00000000200|UniProtKB=H2PY35	Caspase	ISS	8663294	PubMed	PTHR10454:SF157	CASPASE-9
P00030	Hypoxia response via HIF activation	P00819	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05915	Opioid proenkephalin pathway	P05994	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	10799299	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	XENTR|Xenbase=XB-GENE-923233|UniProtKB=Q6AZK9	Nucleoside diphosphate kinase	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	TAS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	HUMAN|HGNC=1603|UniProtKB=P41597	C-C chemokine receptor type 2	ISS			PTHR10489:SF913	C-C CHEMOKINE RECEPTOR TYPE 2
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	MOUSE|MGI=MGI=1278315|UniProtKB=Q91VN0	Low-density lipoprotein receptor-related protein 5	ISS	11029006	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00015	Circadian clock system	G01497	cry	XENTR|Xenbase=XB-GENE-946007|UniProtKB=F6X865	Uncharacterized protein	ISS			PTHR11455:SF16	CRYPTOCHROME-1
P04393	Ras Pathway	P04558	p38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	IDA	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00577	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04393	Ras Pathway	P04544	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	4504111	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00034	Integrin signalling pathway	P00922	Collagen	CHICK|Gene=COL14A1|UniProtKB=P32018	Collagen alpha-1(XIV) chain	IDA	10778855	PubMed	PTHR44557:SF1	COLLAGEN ALPHA-1 XIV  CHAIN
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00034	Integrin signalling pathway	P00907	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02762	Pentose phosphate pathway	P03072	Ribitol Dehydrogenase	ARATH|TAIR=AT4G24050|UniProtKB=O22985	AT4g24050/T19F6_40	ISS	16612264	gi	PTHR24320:SF114	SUBFAMILY NOT NAMED
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02913	Thymidylate synthase	CRYNJ|EnsemblGenome=CNJ01230|UniProtKB=P0CS12	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CAEEL|WormBase=WBGene00003232|UniProtKB=Q09630	Probable metabotropic glutamate receptor mgl-1	IDA	12488551	PubMed	PTHR24060:SF137	METABOTROPIC GLUTAMATE RECEPTOR
P04380	Cortocotropin releasing factor receptor signaling pathway	P04453	ACTH	HUMAN|HGNC=9201|UniProtKB=P01189	Pro-opiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P02788	Xanthine and guanine salvage pathway	P03245	Guanine phosphoribosyl transferase	MYCTU|EnsemblGenome=Rv3624c|UniProtKB=P9WHQ9	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00049	Parkinson disease	P01236	Casein kinase II	LEIMA|EnsemblGenome=LmjF.35.1730|UniProtKB=E9AEZ4	Putative casein kinase II	ISS	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000012005|UniProtKB=F7H091	Metabotropic glutamate receptor 2 isoform a	ISS	9407094	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00010	B cell activation	P00382	Syk	RAT|RGD=3796|UniProtKB=Q64725	Tyrosine-protein kinase SYK	IGI	8137818	PubMed	PTHR24418:SF231	TYROSINE-PROTEIN KINASE SYK
P00009	Axon guidance mediated by netrin	P00356	UNC-5	HUMAN|HGNC=12569|UniProtKB=O95185	Netrin receptor UNC5C	ISS			PTHR12582:SF7	NETRIN RECEPTOR UNC5C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	ARATH|TAIR=AT3G23340|UniProtKB=Q9LW62	AT3g23340/MLM24_21	IDA	11437445	PubMed	PTHR11909:SF178	CASEIN KINASE 1-LIKE PROTEIN 8
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	RAT|RGD=70989|UniProtKB=Q78EA7	Bone morphogenetic protein receptor type-1A	TAS	10683140	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P00048	PI3 kinase pathway	P01206	14-3-3	XENTR|Xenbase=XB-GENE-970616|UniProtKB=Q6P4Z5	14-3-3 protein zeta	ISS	12615066	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00005	Angiogenesis	P00222	VEGFR-2	DANRE|ZFIN=ZDB-GENE-000705-1|UniProtKB=Q8AXB3	Vascular endothelial growth factor receptor kdr-like	ISS			PTHR24416:SF500	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR KDR-LIKE
P04398	p53 pathway feedback loops 2	P04654	Rb	CANLF|Ensembl=ENSCAFG00000004436|UniProtKB=F1PQ32	Uncharacterized protein	ISS			PTHR13742:SF17	RETINOBLASTOMA-ASSOCIATED PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	MACMU|Ensembl=ENSMMUG00000003370|UniProtKB=F7E8G2	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01179	PKB	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00321	HSP70	TAKRU|Ensembl=ENSTRUG00000015162|UniProtKB=H2UP56	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF310	HEAT SHOCK COGNATE 71 KDA PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	ISS	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-040718-93|UniProtKB=Q6DGZ5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P06210	Activin beta signaling pathway	P06236	SMOX	DROME|FlyBase=FBgn0025800|UniProtKB=O96660	Mothers against decapentaplegic homolog	IEA	http://flybase.org/reports/FBrf0190369.html	Website	PTHR13703:SF25	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	HUMAN|HGNC=18539|UniProtKB=P61266	Syntaxin-1B	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	ANOGA|EnsemblGenome=AGAP002440|UniProtKB=Q17031	Cdc42 homolog	ISS	4757952	gi	PTHR24072:SF192	CDC42 HOMOLOG
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-486685|UniProtKB=F6VT32	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	YEAST|SGD=S000000438|UniProtKB=P38328	Actin-related protein 2/3 complex subunit 1	ISS	12963527	gi	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P00049	Parkinson disease	P01230	Src kinase	MOUSE|MGI=MGI=95602|UniProtKB=P39688	Tyrosine-protein kinase Fyn	IDA	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00059	p53 pathway	G04700	PAI	BOVIN|Ensembl=ENSBTAG00000014465|UniProtKB=P13909	Plasminogen activator inhibitor 1	ISS	3183108	gi	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00056	VEGF signaling pathway	P01415	MAPKAPK2/3	MACMU|Ensembl=ENSMMUG00000010495|UniProtKB=F7BFL2	MAP kinase-activated protein kinase 3	ISS	11157753	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P04398	p53 pathway feedback loops 2	G04711	SIAH-1	DANRE|ZFIN=ZDB-GENE-010319-31|UniProtKB=Q7ZVG6	E3 ubiquitin-protein ligase Siah1	ISS	14985507	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P04393	Ras Pathway	P04555	PDK	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	IDA	11256888	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00021	FGF signaling pathway	P00629	PP2A	MONDO|Ensembl=ENSMODG00000002945|UniProtKB=F6PKB8	Uncharacterized protein	ISS	12110603	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01333	cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00053	T cell activation	P01315	Calcineurin	PANTR|Ensembl=ENSPTRG00000020059|UniProtKB=H2QVV0	Serine/threonine-protein phosphatase	ISS	12091710	PubMed	PTHR11668:SF186	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT GAMMA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P02721	ATP synthesis	P02791	F1 alpha	ORNAN|Ensembl=ENSOANG00000014907|UniProtKB=F6V9Q4	ATP synthase subunit alpha (Fragment)	ISS	11479684	PubMed	PTHR43089:SF5	ATP SYNTHASE SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PHYPA|Gene=PHYPADRAFT_213086|UniProtKB=A9SJR1	Beta-tubulin 4	ISS	9454836	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00048	PI3 kinase pathway	P01192	p110	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CANLF|Ensembl=ENSCAFG00000012125|UniProtKB=E2RR72	Uncharacterized protein	ISS			PTHR19957:SF83	SYNTAXIN-16
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00057	Wnt signaling pathway	P01454	betaTrCP	PANTR|Ensembl=ENSPTRG00000017526|UniProtKB=H2QS02	Uncharacterized protein	ISS	10074433	PubMed	PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00059	p53 pathway	G04694	p110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	PANTR|Ensembl=ENSPTRG00000003795|UniProtKB=H2Q3X5	Muscarinic acetylcholine receptor	ISS	11166329	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	HUMAN|HGNC=132|UniProtKB=P60709	Actin, cytoplasmic 1	IC	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04558	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IDA	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00056	VEGF signaling pathway	P01417	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00269	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00015	Circadian clock system	G01499	per	MOUSE|MGI=MGI=1098283|UniProtKB=O35973	Period circadian protein homolog 1	IDA	20570170	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01438	PP2A	CANLF|Ensembl=ENSCAFG00000015787|UniProtKB=F6V7D9	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	RAT|RGD=2342|UniProtKB=P08482	Muscarinic acetylcholine receptor M1	TAS	12181435	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00019	Endothelin signaling pathway	P00566	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	ORNAN|Ensembl=ENSOANG00000006060|UniProtKB=F6PNT9	Integrin beta	ISS	3487386	PubMed	PTHR10082:SF28	INTEGRIN BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05731	GABA-B receptor II signaling	P05753	Ca channel	HUMAN|HGNC=1388|UniProtKB=O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	8386525	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00048	PI3 kinase pathway	P01193	IRS	PANTR|Ensembl=ENSPTRG00000012989|UniProtKB=H2QJJ4	Insulin receptor substrate 1	ISS	15110093	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	DAPPU|EnsemblGenome=DAPPUDRAFT_305638|UniProtKB=E9FWY0	Putative uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF252	BETA-TUBULIN AT 97EF, ISOFORM B
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	2372396	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CHICK|Gene=ACTR2|UniProtKB=P53488	Actin-related protein 2	ISS	10974003	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00056	VEGF signaling pathway	P01423	p38MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04397	p53 pathway by glucose deprivation	P04640	p53	MOUSE|MGI=MGI=1336991|UniProtKB=Q9JJP2	Tumor protein p73	TAS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00049	Parkinson disease	P01238	14-3-3	XENTR|Xenbase=XB-GENE-996375|UniProtKB=F7DY42	Uncharacterized protein	ISS	9450960	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DROME|FlyBase=FBgn0259680|UniProtKB=P83099	Putative protein kinase C delta type homolog	IC	3755548	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00045	Notch signaling pathway	P01116	Delta	MOUSE|MGI=MGI=1859388|UniProtKB=Q9JI71	Delta-like protein 4	IEP	11798067	PubMed	PTHR24044:SF320	DELTA-LIKE PROTEIN 4
P04398	p53 pathway feedback loops 2	P04657	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01143	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CANLF|Ensembl=ENSCAFG00000018530|UniProtKB=F1PXD3	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00029	Huntington disease	P00790	beta-Tubulin	MACMU|Ensembl=ENSMMUG00000012164|UniProtKB=F7GW57	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00003	Alzheimer disease-amyloid secretase pathway	P00093	Tip60	PANTR|Ensembl=ENSPTRG00000021007|UniProtKB=H2QXC2	Uncharacterized protein	ISS			PTHR12345:SF14	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00010	B cell activation	P00381	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00059	p53 pathway	P01486	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	TAS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00220	c-Jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00049	Parkinson disease	P01238	14-3-3	RAT|RGD=61998|UniProtKB=P35213	14-3-3 protein beta/alpha	ISS	10407019	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00875	GEF	MACMU|Ensembl=ENSMMUG00000015072|UniProtKB=F6WVV6	Uncharacterized protein	ISS	11955434	PubMed	PTHR22829:SF6	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE-DEPENDENT RAC EXCHANGER 1 PROTEIN
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	TAKRU|Ensembl=ENSTRUG00000000304|UniProtKB=H2RKM1	Uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00053	T cell activation	P01318	PKC-theta	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	22533439	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00052	TGF-beta signaling pathway	P01286	TGFbeta	PANTR|Ensembl=ENSPTRG00000006562|UniProtKB=H2Q8N5	Transforming growth factor, beta 3	ISS	9759503	PubMed	PTHR11848:SF34	TRANSFORMING GROWTH FACTOR BETA-3
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	HUMAN|HGNC=7601|UniProtKB=Q8NEV4	Myosin-IIIa	ISS			PTHR13140:SF387	MYOSIN-IIIA
P00029	Huntington disease	G01535	PIG3	STRCO|Gene=CAC37461|UniProtKB=Q7AKI0	Putative oxidoreductase	TAS			PTHR43006:SF2	QUINONE OXIDOREDUCTASE PIG3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P06216	SCW signaling pathway	P06323	MED	DROME|FlyBase=FBgn0011655|UniProtKB=O62609	Mothers against decapentaplegic homolog	IEA	9395284	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P00019	Endothelin signaling pathway	P00586	Gq	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PHYPA|Gene=PHYPADRAFT_165677|UniProtKB=Q6TYR3	Beta-tubulin 5	ISS	12932731	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P00012	Cadherin signaling pathway	P00463	betacatenin	MOUSE|MGI=MGI=88276|UniProtKB=Q02248	Catenin beta-1	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00018	EGF receptor signaling pathway	P00557	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MACMU|Ensembl=ENSMMUG00000009679|UniProtKB=F6YBQ8	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00047	PDGF signaling pathway	P01162	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P02768	Proline biosynthesis	P03114	Glutamyl kinase	BACSU|EnsemblGenome=BSU13120|UniProtKB=P39820	Glutamate 5-kinase 1	ISS			PTHR43654:SF3	GLUTAMATE 5-KINASE
P00011	Blood coagulation	P00432	FV	MOUSE|MGI=MGI=88382|UniProtKB=O88783	Coagulation factor V	ISS	6679731	gi	PTHR45199:SF1	COAGULATION FACTOR V
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MACMU|Gene=HTR2A|UniProtKB=P50128	5-hydroxytryptamine receptor 2A	IDA			PTHR24247:SF30	5-HYDROXYTRYPTAMINE RECEPTOR 2A
P00052	TGF-beta signaling pathway	P01275	P38	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00053	T cell activation	P01312	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IDA	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	PANTR|Ensembl=ENSPTRG00000001749|UniProtKB=H2Q0Q4	Uncharacterized protein	ISS	14624853	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000011231|UniProtKB=F6WXV4	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00049	Parkinson disease	P01233	Elk-1	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	IDA	12660819	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00057	Wnt signaling pathway	P01446	Calcineurin	RAT|RGD=3382|UniProtKB=P63329	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	IDA	12015605	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00561	STAT	MACMU|Ensembl=ENSMMUG00000010705|UniProtKB=F7G8V4	Signal transducer and activator of transcription	ISS	7514531	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00053	T cell activation	P01311	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IDA	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02783	Tryptophan biosynthesis	P03209	Anthranilate phosphoribosyl transferase	THEMA|EnsemblGenome=TM_0141|UniProtKB=Q08654	Bifunctional protein TrpGD	ISS			PTHR43418:SF4	MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00114	actin	TRIAD|EnsemblGenome=TriadG49626|UniProtKB=B3RKR4	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01386	TFIIEbeta	MOUSE|MGI=MGI=1915403|UniProtKB=Q9D902	General transcription factor IIE subunit 2	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02772	Pyruvate metabolism	P03140	Pyruvate Carboxylase	HUMAN|HGNC=8636|UniProtKB=P11498	Pyruvate carboxylase, mitochondrial	NAS	200246	gi	PTHR43778:SF2	PYRUVATE CARBOXYLASE, MITOCHONDRIAL
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014555|UniProtKB=F7GT55	Syntaxin-1A isoform 1	ISS	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00996	STAT	MACMU|Ensembl=ENSMMUG00000000803|UniProtKB=F6R1P6	Signal transducer and activator of transcription	ISS			PTHR11801:SF41	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 2
P00006	Apoptosis signaling pathway	P00269	MAPK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01173	STAT	MACMU|Ensembl=ENSMMUG00000017527|UniProtKB=F6UMM2	Signal transducer and activator of transcription	ISS	94367369	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00048	PI3 kinase pathway	P01199	Galpha	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	IC	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00006	Apoptosis signaling pathway	P00290	Blk	RAT|RGD=621547|UniProtKB=Q925D2	Bcl2-interacting killer, isoform CRA_a	ISS	11884414	PubMed	PTHR15018:SF1	BCL-2-INTERACTING KILLER
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04633	P110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	YEAST|SGD=S000001295|UniProtKB=P07278	cAMP-dependent protein kinase regulatory subunit	IC	2372396	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00011	Blood coagulation	P00447	FVIIa	HUMAN|HGNC=3544|UniProtKB=P08709	Coagulation factor VII	ISS	4503645	gi	PTHR44064:SF1	COAGULATION FACTOR VII
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00017	DNA replication	P00536	DNA Topisomerase	CHICK|Gene=TOP2A|UniProtKB=O42130	DNA topoisomerase 2-alpha	ISS			PTHR10169:SF46	DNA TOPOISOMERASE 2-ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05913	Enkephalin release	P05975	GPCR (s)	BOVIN|Gene=OPRM1|UniProtKB=P79350	Mu-type opioid receptor	ISS	11259498	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P04376	5HT4 type receptor mediated signaling pathway	P04426	K+ channel	CHICK|Ensembl=ENSGALG00000016193|UniProtKB=E1BYI0	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	PANTR|Ensembl=ENSPTRG00000002086|UniProtKB=H2Q1A9	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00021	FGF signaling pathway	P00629	PP2A	BRAFL|Gene=BRAFLDRAFT_123893|UniProtKB=C3XQF4	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P02723	Adenine and hypoxanthine salvage pathway	P02810	Adenine phosphoribosyl transferase	GIAIC|EnsemblGenome=GL50803_112885|UniProtKB=E2RTW6	Adenine phosphoribosyltransferase	ISS			PTHR11776:SF0	ADENINE PHOSPHORIBOSYLTRANSFERASE-RELATED
P05913	Enkephalin release	P05977	G-Protein (s)	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00095	Nicastrin	PANTR|Ensembl=ENSPTRG00000001550|UniProtKB=H2Q0E4	Nicastrin	ISS	16096062	PubMed	PTHR21092:SF0	NICASTRIN
P05731	GABA-B receptor II signaling	P05753	Ca channel	BOVIN|Ensembl=ENSBTAG00000014828|UniProtKB=F1N1E0	Uncharacterized protein	ISS	14507926	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000024633|UniProtKB=F1MBU9	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00010	B cell activation	P00397	IKK	BOVIN|Ensembl=ENSBTAG00000007591|UniProtKB=Q95KV1	Inhibitor of nuclear factor kappa-B kinase subunit alpha	IGI	9346484	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01456	beta-arrestin	CANLF|Ensembl=ENSCAFG00000015905|UniProtKB=E2QUH6	Uncharacterized protein	ISS	12464600	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01465	Ggamma	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00034	Integrin signalling pathway	P00927	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	20010089	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00012	Cadherin signaling pathway	P00474	Wnt	MACMU|Ensembl=ENSMMUG00000002439|UniProtKB=F6PJN8	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P00010	B cell activation	P00397	IKK	MOUSE|MGI=MGI=99484|UniProtKB=Q60680	Inhibitor of nuclear factor kappa-B kinase subunit alpha	IGI	12813046	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00005	Angiogenesis	P00186	FGFR-1	CHICK|Gene=FGFR1|UniProtKB=P21804	Fibroblast growth factor receptor 1	ISS	2544996	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05968	CLIC6	MOUSE|MGI=MGI=2146607|UniProtKB=Q8BHB9	Chloride intracellular channel protein 6	ISS			PTHR45476:SF1	CHLORIDE INTRACELLULAR CHANNEL PROTEIN 6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00011	Blood coagulation	P00458	GP IIIa	MACMU|Ensembl=ENSMMUG00000003289|UniProtKB=F7FG54	Integrin beta	ISS	484963	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DANRE|ZFIN=ZDB-GENE-030131-172|UniProtKB=Q6IQR3	Actin, alpha, cardiac muscle 1a	ISS	14684598	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P04392	P53 pathway feedback loops 1	P04538	Pirh-2	HUMAN|HGNC=17479|UniProtKB=Q96PM5	RING finger and CHY zinc finger domain-containing protein 1	ISS	607680	OMIM	PTHR21319:SF20	RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00845	Cyclooxygenase	CANLF|Ensembl=ENSCAFG00000013762|UniProtKB=Q8SPQ9	Cyclooxygenase 2	ISS	12163371	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P00045	Notch signaling pathway	P01114	Ntm	RAT|RGD=3188|UniProtKB=Q9QW30	Neurogenic locus notch homolog protein 2	IEP	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00203	Erk	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	BOVIN|Ensembl=ENSBTAG00000016187|UniProtKB=F1N213	Uncharacterized protein	ISS	11431030	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	TAKRU|Ensembl=ENSTRUG00000004479|UniProtKB=H2SE17	Uncharacterized protein	ISS			PTHR43962:SF2	MELATONIN RECEPTOR TYPE 1A
P00048	PI3 kinase pathway	P01192	p110	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P04609	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	ISS	129387	gi	PTHR10048:SF14	PI-3 KINASE
P02728	Arginine biosynthesis	P02842	N-acetylornithine aminotransferase	BACSU|EnsemblGenome=BSU11220|UniProtKB=P36839	Acetylornithine aminotransferase	ISS	10074354	PubMed	PTHR11986:SF79	ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00203	Erk	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00045	Notch signaling pathway	P01110	Presenilin	MACMU|Ensembl=ENSMMUG00000010173|UniProtKB=F7AGU8	Presenilin	ISS	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P00021	FGF signaling pathway	P00645	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	10891487	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00047	PDGF signaling pathway	P01173	STAT	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	ISS	14984365	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	DROME|FlyBase=FBgn0015519|UniProtKB=Q9W3G6	Nicotinic acetylcholine receptor alpha3, isoform B	ISS	85270494	PubMed	PTHR18945:SF758	NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA3, ISOFORM B
P04398	p53 pathway feedback loops 2	G04711	SIAH-1	HUMAN|HGNC=10857|UniProtKB=Q8IUQ4	E3 ubiquitin-protein ligase SIAH1	ISS	11389839	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00057	Wnt signaling pathway	P01432	Beta-Catenin	HUMAN|HGNC=2514|UniProtKB=P35222	Catenin beta-1	IDA	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00005	Angiogenesis	P00203	Erk	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00010	B cell activation	P00374	Lyn	RAT|RGD=621017|UniProtKB=Q07014	Tyrosine-protein kinase Lyn	IDA	11078745	PubMed	PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	BOVIN|Ensembl=ENSBTAG00000026660|UniProtKB=Q3T174	Transcription initiation factor TFIID subunit 12	ISS			PTHR12264:SF21	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12
P00005	Angiogenesis	P00236	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00006	Apoptosis signaling pathway	P00321	HSP70	NEUCR|EnsemblGenome=EFNCRG00000009411|UniProtKB=Q01233	Heat shock 70 kDa protein	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00029	Huntington disease	P00805	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	PHYPA|Gene=PHYPADRAFT_107830|UniProtKB=A9TBG2	Actin 7	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00054	Toll receptor signaling pathway	P01352	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00059	p53 pathway	P01486	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00057	Wnt signaling pathway	P01465	Ggamma	RAT|RGD=621516|UniProtKB=G3V6P8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00012	Cadherin signaling pathway	P00464	Fyn	CANLF|Ensembl=ENSCAFG00000003995|UniProtKB=E2RC09	Tyrosine-protein kinase	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_127488|UniProtKB=C3XYC7	Putative uncharacterized protein	IDA	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00019	Endothelin signaling pathway	P00578	eNOS	HUMAN|HGNC=7876|UniProtKB=P29474	Nitric oxide synthase, endothelial	ISS	9837777	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	IDA	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00045	Notch signaling pathway	P01103	Next	HUMAN|HGNC=7881|UniProtKB=P46531	Neurogenic locus notch homolog protein 1	IGI	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01412	HSP27	ANOGA|EnsemblGenome=AGAP007158|UniProtKB=Q7PCM8	AGAP007158-PA	ISS			PTHR11527:SF252	HEAT SHOCK PROTEIN BETA-11
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05913	Enkephalin release	P05977	G-Protein (s)	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00049	Parkinson disease	P01242	Casein kinase I	PANTR|Ensembl=ENSPTRG00000014365|UniProtKB=H2R0C8	Casein kinase 1, epsilon	ISS	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00020	FAS signaling pathway	P00605	Pro-Caspase7	HUMAN|HGNC=1508|UniProtKB=P55210	Caspase-7	IGI	14583630	PubMed	PTHR10454:SF31	CASPASE-7
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	MOUSE|MGI=MGI=104635|UniProtKB=Q9WVB2	Transducin-like enhancer protein 2	IDA	9783586	PubMed	PTHR10814:SF4	AMINO-TERMINAL ENHANCER OF SPLIT-RELATED
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00010	B cell activation	P00391	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	RCA	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000006342|UniProtKB=H2Q8A8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00012	Cadherin signaling pathway	P00474	Wnt	MACMU|Ensembl=ENSMMUG00000004904|UniProtKB=F7CJE4	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P02738	De novo purine biosynthesis	P02892	5-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase	SULSO|EnsemblGenome=SSO0240|UniProtKB=Q980P8	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P00029	Huntington disease	P00810	GAPDH	YEAST|SGD=S000003588|UniProtKB=P00360	Glyceraldehyde-3-phosphate dehydrogenase 1	IPI			PTHR10836:SF52	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MOUSE|MGI=MGI=104589|UniProtKB=P63268	Actin, gamma-enteric smooth muscle	IDA	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00018	EGF receptor signaling pathway	P00545	JNK1-3	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00629	PP2A	MOUSE|MGI=MGI=2388480|UniProtKB=Q6PD28	Protein Ppp2r5b	ISS	96161994	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P06959	CCKR signaling map	P07129	FAK1	HUMAN|HGNC=9611|UniProtKB=Q05397	Focal adhesion kinase 1	RCA	14667936	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000005917|UniProtKB=F6QM53	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000016666|UniProtKB=H2QQJ6	Uncharacterized protein	ISS	8120095	PubMed	PTHR24026:SF42	PROTOCADHERIN FAT 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00046	Oxidative stress response	P01135	p38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	TAS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00029	Huntington disease	P00796	Kainate receptor	CANLF|Ensembl=ENSCAFG00000004930|UniProtKB=E2RFB5	Uncharacterized protein	ISS	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00015	Circadian clock system	G01501	cry	HUMAN|HGNC=2384|UniProtKB=Q16526	Cryptochrome-1	IEP	14507900	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	ANOGA|EnsemblGenome=AGAP009685|UniProtKB=Q7PM06	Aspartate aminotransferase	ISS			PTHR11879:SF10	ASPARTATE AMINOTRANSFERASE
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IGI	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00046	Oxidative stress response	P01135	p38	CAEEL|WormBase=WBGene00004056|UniProtKB=Q8MXI4	Mitogen-activated protein kinase pmk-2	TAS	10851062	PubMed	PTHR24055:SF154	MITOGEN-ACTIVATED PROTEIN KINASE PMK-2
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	RCA	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01304	Csk	HUMAN|HGNC=2444|UniProtKB=P41240	Tyrosine-protein kinase CSK	IDA	11078745	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00870	IL2	MOUSE|MGI=MGI=96541|UniProtKB=P20109	Interleukin-13	TAS			PTHR45413:SF1	INTERLEUKIN-13
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P02747	Histidine biosynthesis	P02991	Histidinephosphate aminotransferase	STRCO|EnsemblGenome=CAA22216|UniProtKB=Q9ZBY8	Putative phenylalanine aminotransferase	ISS			PTHR43643:SF3	SUBFAMILY NOT NAMED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PANTR|Ensembl=ENSPTRG00000009762|UniProtKB=H2QE24	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	XENTR|Xenbase=XB-GENE-989959|UniProtKB=F6WGT0	Uncharacterized protein	ISS			PTHR10943:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00034	Integrin signalling pathway	P00907	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01464	Pygo	RAT|RGD=1308535|UniProtKB=B5DFG8	Protein Pygo2	ISS	11955446	PubMed	PTHR23194:SF7	PYGOPUS HOMOLOG 2
P00036	Interleukin signaling pathway	P00970	Interleukin	RAT|RGD=2901|UniProtKB=P20607	Interleukin-6	IC			PTHR45110:SF1	INTERLEUKIN-6
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ARATH|TAIR=AT2G42100|UniProtKB=Q8RYC2	Putative actin-5	ISS	10974003	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00036	Interleukin signaling pathway	P00987	SRF	PANTR|Ensembl=ENSPTRG00000018189|UniProtKB=H2QT21	Uncharacterized protein	ISS	15647354	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00052	TGF-beta signaling pathway	P01288	FKBP12	MACMU|Ensembl=ENSMMUG00000012945|UniProtKB=F6RJJ7	Peptidyl-prolyl cis-trans isomerase	ISS			PTHR10516:SF333	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Gene=CHRM5|UniProtKB=Q5IS53	Muscarinic acetylcholine receptor M5	ISS			PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000008503|UniProtKB=F6TGJ6	Uncharacterized protein	ISS	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00005	Angiogenesis	P00245	Rac	MACMU|Ensembl=ENSMMUG00000007831|UniProtKB=F7CI83	Rho GTPase-activating protein 1	ISS	14724572	PubMed	PTHR23176:SF28	RHO GTPASE-ACTIVATING PROTEIN 1
P00021	FGF signaling pathway	P00647	SHP2	MONDO|Ensembl=ENSMODG00000003120|UniProtKB=F6WVD2	Tyrosine-protein phosphatase non-receptor type	ISS	14525967	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00005	Angiogenesis	P00206	Wnt	PANTR|Ensembl=ENSPTRG00000001108|UniProtKB=H2PZP0	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	YEAST|SGD=S000004362|UniProtKB=Q05933	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00010	B cell activation	P00371	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00045	Notch signaling pathway	P01103	Next	MACMU|Ensembl=ENSMMUG00000018375|UniProtKB=F7H1D5	Neurogenic locus notch homolog protein 2 isoform 1 preproprotein	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00005	Angiogenesis	P00203	Erk	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00046	Oxidative stress response	P01135	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	TAS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	15470041	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P06214	GBB signaling pathway	P06307	SAX	DROME|Gene=Dmel_CG1891|UniProtKB=A0A0B4K7J3	Receptor protein serine/threonine kinase	IDA	9395284	PubMed	PTHR23255:SF72	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00019	Endothelin signaling pathway	P00573	signal peptidase	SCHPO|PomBase=SPBC1685.03|UniProtKB=O74323	Signal peptidase complex catalytic subunit sec11	ISS	2092035	PubMed	PTHR10806:SF6	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11
P00034	Integrin signalling pathway	P00922	Collagen	RAT|RGD=2375|UniProtKB=P05539	Collagen alpha-1(II) chain	IDA	10778855	PubMed	PTHR24023:SF58	COLLAGEN ALPHA-1 II  CHAIN
P00057	Wnt signaling pathway	P01457	GBeta	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IDA	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00053	T cell activation	P01305	Calmodulin	TRIAD|EnsemblGenome=TriadG37105|UniProtKB=B3RJX8	Calmodulin	ISS			PTHR23050:SF245	AT16150P-RELATED
P00029	Huntington disease	P00805	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	BOVIN|Ensembl=ENSBTAG00000000895|UniProtKB=G5E509	Uncharacterized protein	ISS			PTHR12595:SF3	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 9B
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	XENTR|Xenbase=XB-GENE-1005779|UniProtKB=F7E3I6	Uncharacterized protein	ISS	11861492	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00052	TGF-beta signaling pathway	P01275	P38	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	TAS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00057	Wnt signaling pathway	P01448	CBP	CAEEL|WormBase=WBGene00009595|UniProtKB=Q7JMS5	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00035	Interferon-gamma signaling pathway	P00958	PIAS	DROME|FlyBase=FBgn0003612|UniProtKB=A1Z7P5	Suppressor of variegation 2-10, isoform I	ISS			PTHR10782:SF4	SUPPRESSOR OF VARIEGATION 2-10, ISOFORM I
P00020	FAS signaling pathway	P00601	c-Jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	DANRE|ZFIN=ZDB-GENE-980526-332|UniProtKB=P51028	Protein Wnt-8a	TAS	11266476	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00018	EGF receptor signaling pathway	P00561	STAT	MACMU|Ensembl=ENSMMUG00000010705|UniProtKB=F7G8V4	Signal transducer and activator of transcription	ISS	8732682	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	RCA	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00029	Huntington disease	P00780	Microtubule	BOVIN|Ensembl=ENSBTAG00000023730|UniProtKB=Q2T9S0	Tubulin beta-3 chain	ISS	9454836	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00029	Huntington disease	P00774	Dynein complex	DANRE|ZFIN=ZDB-GENE-040426-1961|UniProtKB=Q6PBH4	Dynein, light chain, LC8-type 2	ISS	9454836	PubMed	PTHR11886:SF62	DYNEIN, LIGHT CHAIN, LC8-TYPE 2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	DROME|FlyBase=FBgn0001991|UniProtKB=Q24270	Voltage-dependent calcium channel type D subunit alpha-1	ISS	10514528	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00056	VEGF signaling pathway	P01425	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00020	FAS signaling pathway	P00594	Caspase8	MOUSE|MGI=MGI=1261423|UniProtKB=O89110	Caspase-8	IGI	11788820	PubMed	PTHR10454:SF162	CASPASE-8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00053	T cell activation	P01331	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00034	Integrin signalling pathway	P00948	Rho	CANLF|Ensembl=ENSCAFG00000014610|UniProtKB=E2RKC5	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF21	RHO-RELATED GTP-BINDING PROTEIN RHON
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CAEEL|WormBase=WBGene00000067|UniProtKB=O45815	ACTin	IC	10974003	PubMed	PTHR11937:SF352	ACTIN
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00640	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IGI	14526383	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00030	Hypoxia response via HIF activation	P00819	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	CAEEL|WormBase=WBGene00006542|UniProtKB=P32085	TATA-box-binding protein	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P06959	CCKR signaling map	P07080	COX2	HUMAN|HGNC=9605|UniProtKB=P35354	Prostaglandin G/H synthase 2	RCA	18395088	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	MOUSE|MGI=MGI=106613|UniProtKB=Q60838	Segment polarity protein dishevelled homolog DVL-2	TAS	10409711	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P00036	Interleukin signaling pathway	P00973	PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	G01535	PIG3	RHOBA|EnsemblGenome=RB11985|UniProtKB=Q7UJC3	Quinone oxidoreductase	TAS			PTHR44154:SF1	QUINONE OXIDOREDUCTASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00046	Oxidative stress response	P01129	JNK1/2	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00624	14-3-3	CANLF|Ensembl=ENSCAFG00000009514|UniProtKB=F1PKW7	Uncharacterized protein	ISS	21864508	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P05915	Opioid proenkephalin pathway	P05994	G-protein	ARATH|TAIR=AT4G34460|UniProtKB=P49177	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF48	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA
P00006	Apoptosis signaling pathway	P00269	MAPK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	MACMU|Ensembl=ENSMMUG00000006253|UniProtKB=F7H582	Uncharacterized protein	ISS	10978539	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00034	Integrin signalling pathway	P00916	Ras	DAPPU|EnsemblGenome=DAPPUDRAFT_301818|UniProtKB=E9I1I7	Putative uncharacterized protein	ISS	10684567	PubMed	PTHR24070:SF385	GTPASE HRAS
P00021	FGF signaling pathway	P00625	MKK3,6	BOVIN|Ensembl=ENSBTAG00000001609|UniProtKB=Q5E9X2	Dual specificity mitogen-activated protein kinase kinase 6	RCA			PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MONDO|Ensembl=ENSMODG00000001196|UniProtKB=F7GH85	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=621089|UniProtKB=F1LMI3	Cadherin 3, type 1, P-cadherin (Placental)	ISS	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	RAT|RGD=621005|UniProtKB=Q08849	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	SCHPO|PomBase=SPAC22E12.09c|UniProtKB=Q09175	Dibasic-processing endoprotease	IDA			PTHR42884:SF14	NEUROENDOCRINE CONVERTASE 1
P05913	Enkephalin release	P05977	G-Protein (s)	DROME|FlyBase=FBgn0030011|UniProtKB=Q9W3J1	Gbeta5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=1352756|UniProtKB=Q8K394	Inactive phospholipase C-like protein 2	ISS			PTHR10336:SF84	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2058|UniProtKB=P22086	Alpha-2C adrenergic receptor	IDA	11781138	PubMed	PTHR24248:SF25	ALPHA-2C ADRENERGIC RECEPTOR
P00057	Wnt signaling pathway	P01443	Phospholipase C	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00059	p53 pathway	P01486	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	CANLF|Ensembl=ENSCAFG00000019633|UniProtKB=F1PDC7	Uncharacterized protein	ISS	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00029	Huntington disease	P00777	CBP	MACMU|Ensembl=ENSMMUG00000000893|UniProtKB=F6T7D0	Histone acetyltransferase p300	ISS	8413673	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000015640|UniProtKB=E2QVF3	Uncharacterized protein	ISS	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00057	Wnt signaling pathway	P01443	Phospholipase C	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P02784	Tyrosine biosynthesis	P03212	Chorismate mutase	YEAST|SGD=S000006264|UniProtKB=P32178	Chorismate mutase	ISS			PTHR21145:SF0	CHORISMATE MUTASE
P00010	B cell activation	P00391	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00047	PDGF signaling pathway	P01161	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	ARATH|TAIR=AT5G61210|UniProtKB=Q9S7P9	SNAP25 homologous protein SNAP33	IC			PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	MACMU|Ensembl=ENSMMUG00000010184|UniProtKB=F6SR09	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00038	JAK/STAT signaling pathway	P01027	STAT	MONDO|Ensembl=ENSMODG00000028212|UniProtKB=F7BYN4	Signal transducer and activator of transcription	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00036	Interleukin signaling pathway	P00970	Interleukin	CHICK|Ensembl=ENSGALG00000010915|UniProtKB=Q90YI0	Interleukin-6	IC			PTHR45110:SF1	INTERLEUKIN-6
P00029	Huntington disease	P00807	Actin	HUMAN|HGNC=130|UniProtKB=P62736	Actin, aortic smooth muscle	IDA	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00034	Integrin signalling pathway	P00931	Integrin beta	MOUSE|MGI=MGI=96612|UniProtKB=O54890	Integrin beta-3	IDA	5805339	gi	PTHR10082:SF25	INTEGRIN BETA-3
P02738	De novo purine biosynthesis	P02899	GMP synthase	HUMAN|HGNC=4378|UniProtKB=P49915	GMP synthase [glutamine-hydrolyzing]	ISS			PTHR11922:SF2	GMP SYNTHASE  GLUTAMINE-HYDROLYZING
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	YEAST|SGD=S000001855|UniProtKB=P60010	Actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	HUMAN|HGNC=16767|UniProtKB=Q8TCU5	Glutamate receptor ionotropic, NMDA 3A	ISS	14698601	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00034	Integrin signalling pathway	P00936	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00006	Apoptosis signaling pathway	P00269	MAPK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	ISS	13430383	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	TAS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CANLF|Ensembl=ENSCAFG00000000332|UniProtKB=F1P8E3	Uncharacterized protein	ISS			PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_127490|UniProtKB=C3XYC5	Putative uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00049	Parkinson disease	P01227	20S proteasome	ANOGA|EnsemblGenome=AGAP003935|UniProtKB=Q7Q2B0	Proteasome subunit alpha type	TAS	12859888	PubMed	PTHR11599:SF11	PROTEASOME SUBUNIT ALPHA TYPE-6
P00047	PDGF signaling pathway	P01142	p90RSK	BOVIN|Ensembl=ENSBTAG00000014447|UniProtKB=A4IFF4	Ribosomal protein S6 kinase	ISS	7688567	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00005	Angiogenesis	P00190	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	2574500	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00009	Axon guidance mediated by netrin	P00357	Netrin	MOUSE|MGI=MGI=1341188|UniProtKB=Q9R1A3	Netrin-3	ISS			PTHR10574:SF292	NETRIN-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	ISS	10556059	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	IDA	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00045	Notch signaling pathway	P01103	Next	HUMAN|HGNC=7883|UniProtKB=Q9UM47	Neurogenic locus notch homolog protein 3	IC	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P02741	Flavin biosynthesis	P02936	FAD synthetase	YEAST|SGD=S000002203|UniProtKB=P38913	FAD synthase	RCA			PTHR23293:SF9	FAD SYNTHASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00048	PI3 kinase pathway	P01177	P110ACT	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	IC	9094314	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00936	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IPI	7937853	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P04393	Ras Pathway	P04542	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	YEAST|SGD=S000000028|UniProtKB=P31109	Synaptobrevin homolog 1	ISS			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00053	T cell activation	P01322	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	ISS	11256888	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04392	P53 pathway feedback loops 1	G04685	p73DeltaN	MACMU|Ensembl=ENSMMUG00000016466|UniProtKB=F7GBH1	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00053	T cell activation	P01312	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00561	STAT	BOVIN|Gene=STAT3|UniProtKB=P61635	Signal transducer and activator of transcription 3	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00006	Apoptosis signaling pathway	P00318	PKCs	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00011	Blood coagulation	P00426	PC	MOUSE|MGI=MGI=97771|UniProtKB=P33587	Vitamin K-dependent protein C	ISS	6679477	gi	PTHR24278:SF0	VITAMIN K-DEPENDENT PROTEIN C
P00036	Interleukin signaling pathway	P00981	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00010	B cell activation	P00383	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04376	5HT4 type receptor mediated signaling pathway	P04431	5HT transporter	CANLF|Ensembl=ENSCAFG00000018990|UniProtKB=F1PXA1	Transporter	ISS	14653308	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IDA	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	IDA	15210700	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00006	Apoptosis signaling pathway	P00274	JNK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	ISS	10514528	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01435	SWI/SNF	CANLF|Ensembl=ENSCAFG00000012708|UniProtKB=E2RN43	Uncharacterized protein	ISS	11532957	PubMed	PTHR13844:SF2	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D MEMBER 2
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	BOVIN|Ensembl=ENSBTAG00000043971|UniProtKB=E1BPT8	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00049	Parkinson disease	P01222	Ubc6	BOVIN|Ensembl=ENSBTAG00000015882|UniProtKB=Q2TA03	Ubiquitin-conjugating enzyme E2 J2	ISS	12859888	PubMed	PTHR43972:SF1	UBIQUITIN-CONJUGATING ENZYME E2 J2
P00021	FGF signaling pathway	P00629	PP2A	MONDO|Ensembl=ENSMODG00000019001|UniProtKB=F7CP86	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00037	Ionotropic glutamate receptor pathway	P01021	Vglut	MACMU|Ensembl=ENSMMUG00000017646|UniProtKB=F6UIA5	Uncharacterized protein	ISS	12815758	PubMed	PTHR11662:SF207	VESICULAR GLUTAMATE TRANSPORTER 3
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	11035810	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00038	JAK/STAT signaling pathway	P01034	Jak	BOVIN|Ensembl=ENSBTAG00000012047|UniProtKB=E1BCP6	Tyrosine-protein kinase	ISS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00010	B cell activation	P00381	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	3449797	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00048	PI3 kinase pathway	P01199	Galpha	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	PANTR|Ensembl=ENSPTRG00000001477|UniProtKB=H2Q0A5	Tyrosine-protein kinase receptor	ISS	10226785	PubMed	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	HUMAN|HGNC=2510|UniProtKB=P26232	Catenin alpha-2	TAS	9362521	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	MACMU|Ensembl=ENSMMUG00000004046|UniProtKB=F6ZR77	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00019	Endothelin signaling pathway	P00570	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	IDA	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00059	p53 pathway	P04633	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00774	Dynein complex	XENTR|Xenbase=XB-GENE-854521|UniProtKB=Q6DEU5	Dynein light chain 2	ISS	9454836	PubMed	PTHR11886:SF62	DYNEIN, LIGHT CHAIN, LC8-TYPE 2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00048	PI3 kinase pathway	P01181	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00014	Cholesterol biosynthesis	P00490	Dimethylallyl trans-transferase	HUMAN|HGNC=4249|UniProtKB=O95749	Geranylgeranyl pyrophosphate synthase	RCA			PTHR12001:SF44	GERANYLGERANYL PYROPHOSPHATE SYNTHASE
P04397	p53 pathway by glucose deprivation	P04640	p53	CANLF|Gene=TP53|UniProtKB=Q29537	Cellular tumor antigen p53	TAS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BOVIN|Ensembl=ENSBTAG00000006189|UniProtKB=P63258	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	ANOGA|EnsemblGenome=AGAP010172|UniProtKB=Q7PD38	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00019	Endothelin signaling pathway	P00591	PLCbeta	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	MACMU|Ensembl=ENSMMUG00000011231|UniProtKB=F6WXV4	Uncharacterized protein	ISS	11431030	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MOUSE|MGI=MGI=87911|UniProtKB=P37172	Activin receptor type-1	TAS	9395284	PubMed	PTHR23255:SF69	ACTIVIN RECEPTOR TYPE-1
P04393	Ras Pathway	P04570	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PHYIT|EnsemblGenome=PITG_15117|UniProtKB=D0NRP9	Actin-like protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	SCHMA|EnsemblGenome=Smp_030730|UniProtKB=G4LW34	Tubulin beta chain,putative	ISS	9454836	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00029	Huntington disease	P00811	Arp2/3 complex	CANLF|Ensembl=ENSCAFG00000015081|UniProtKB=E2RMT4	Uncharacterized protein	ISS	12963527	gi	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00029	Huntington disease	G01533	Bax	RAT|RGD=2192|UniProtKB=Q63690	Apoptosis regulator BAX	ISS	14963330	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	XENTR|Xenbase=XB-GENE-854877|UniProtKB=F7C949	Presenilin	ISS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00053	T cell activation	P01320	PLC-gamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00048	PI3 kinase pathway	P01181	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P06664	Gonadotropin-releasing hormone receptor pathway	P06769	Gbeta	MOUSE|MGI=MGI=101848|UniProtKB=P62881	Guanine nucleotide-binding protein subunit beta-5	RCA	11313908	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00034	Integrin signalling pathway	P00944	Actin	MONDO|Ensembl=ENSMODG00000025373|UniProtKB=F6ZZG9	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00005	Angiogenesis	P00212	EphR	HUMAN|HGNC=3392|UniProtKB=P54762	Ephrin type-B receptor 1	RCA			PTHR24416:SF173	EPHRIN TYPE-B RECEPTOR 1
P00057	Wnt signaling pathway	P01457	GBeta	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IDA	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	CHICK|Ensembl=ENSGALG00000005998|UniProtKB=Q5ZIW8	Uncharacterized protein	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00018	EGF receptor signaling pathway	P00555	MKK4,7	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05915	Opioid proenkephalin pathway	P05993	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04398	p53 pathway feedback loops 2	P04651	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00025	Hedgehog signaling pathway	P00693	Ubiquitin ligase	PANTR|Ensembl=ENSPTRG00000020482|UniProtKB=H2QWJ0	Uncharacterized protein	ISS			PTHR11254:SF402	E3 UBIQUITIN-PROTEIN LIGASE UBR5
P00034	Integrin signalling pathway	P00951	Jnk	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00029	Huntington disease	G01535	PIG3	ORYSJ|EnsemblGenome=OS02G0805600|UniProtKB=Q6K840	Os02g0805600 protein	TAS			PTHR43006:SF7	SUBFAMILY NOT NAMED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04452	proopiomelanocortin	MONDO|Ensembl=ENSMODG00000015853|UniProtKB=Q95J84	Proopiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00019	Endothelin signaling pathway	P00586	Gq	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00048	PI3 kinase pathway	P01185	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00049	Parkinson disease	P01227	20S proteasome	ARATH|TAIR=AT3G27430|UniProtKB=O23710	Proteasome subunit beta type-7-A	TAS	12859888	PubMed	PTHR11599:SF44	AT05866P-RELATED
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00029	Huntington disease	P00778	NMDA receptor	BOVIN|Ensembl=ENSBTAG00000000219|UniProtKB=F1MCL3	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00046	Oxidative stress response	P01122	TRX	SCHMA|EnsemblGenome=Smp_008070|UniProtKB=Q8T9N5	Thioredoxin	ISS			PTHR10438:SF284	THIOREDOXIN-LIKE PROTEIN 1
P00036	Interleukin signaling pathway	P00966	mTOR	HUMAN|HGNC=3942|UniProtKB=P42345	Serine/threonine-protein kinase mTOR	IPI	14526383	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	STRPU|EnsemblGenome=SPU_007425|UniProtKB=W4XVG9	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00057	Wnt signaling pathway	P01465	Ggamma	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00047	PDGF signaling pathway	P01153	GSK3	ORYSJ|EnsemblGenome=OS10G0521700|UniProtKB=Q8LNI5	Os10g0521700 protein	ISS	21361340	gi	PTHR24057:SF19	SHAGGY-RELATED PROTEIN KINASE BETA-RELATED
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IGI	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	8170357	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00023	General transcription regulation	P00660	RNA Polymerase II	MOUSE|MGI=MGI=1913670|UniProtKB=Q80UW8	DNA-directed RNA polymerases I, II, and III subunit RPABC1	ISS			PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P00057	Wnt signaling pathway	P01451	Galpha	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05913	Enkephalin release	P05974	G-Protein (i)	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00575	furin	HUMAN|HGNC=8743|UniProtKB=P29120	Neuroendocrine convertase 1	ISS			PTHR42884:SF14	NEUROENDOCRINE CONVERTASE 1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	RCA	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00056	VEGF signaling pathway	P01413	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00023	General transcription regulation	P00662	TFIIA complex	NEUCR|EnsemblGenome=EFNCRG00000002012|UniProtKB=Q7SG05	Uncharacterized protein	ISS	600519	OMIM	PTHR12694:SF8	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	DANRE|ZFIN=ZDB-GENE-050417-59|UniProtKB=Q15KE4	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CRYNJ|EnsemblGenome=CNA03840|UniProtKB=Q5KP84	Protein serine/threonine kinase, putative	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	IDA	9836510	gi	PTHR24055:SF330	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00810	GAPDH	MOUSE|MGI=MGI=95653|UniProtKB=Q64467	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific	IPI			PTHR10836:SF79	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE, TESTIS-SPECIFIC
P00019	Endothelin signaling pathway	P00581	Guanylate cyclase	RAT|RGD=2769|UniProtKB=P20595	Guanylate cyclase soluble subunit beta-1	RCA			PTHR11920:SF318	GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-1
P00047	PDGF signaling pathway	P01168	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	ISS	12660731	PubMed	PTHR10048:SF14	PI-3 KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04551	RalGDS	MOUSE|MGI=MGI=107484|UniProtKB=Q60695	Ral guanine nucleotide dissociation stimulator-like 1	ISS			PTHR23113:SF199	RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 1
P02769	Purine metabolism	P03116	Xanthine Oxidase	CHICK|Gene=XDH|UniProtKB=P47990	Xanthine dehydrogenase/oxidase	ISS	7852355	PubMed	PTHR11908:SF80	XANTHINE DEHYDROGENASE/OXIDASE
P00019	Endothelin signaling pathway	P00589	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00564	Rac	MONDO|Ensembl=ENSMODG00000003244|UniProtKB=F6THF0	Uncharacterized protein	ISS	9254684	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00029	Huntington disease	P00797	p53	PANTR|Ensembl=ENSPTRG00000015733|UniProtKB=H2QNY5	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P06212	DPP-SCW signaling pathway	P06263	FUR1	DROME|FlyBase=FBgn0004509|UniProtKB=P26016	Furin-like protease 1, isoforms 1/1-X/2	IEA	10956649	PubMed	PTHR42884:SF3	FURIN-LIKE PROTEASE 1, ISOFORMS 1/1-X/2
P00056	VEGF signaling pathway	P01425	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MOUSE|MGI=MGI=109269|UniProtKB=O08717	Inhibin beta E chain	TAS	9759503	PubMed	PTHR11848:SF6	INHIBIN BETA E CHAIN
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00057	Wnt signaling pathway	P01435	SWI/SNF	BOVIN|Ensembl=ENSBTAG00000003399|UniProtKB=F1N052	Uncharacterized protein	ISS	11532957	PubMed	PTHR10799:SF887	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	CANLF|Ensembl=ENSCAFG00000004956|UniProtKB=E2REH3	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	TAS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00021	FGF signaling pathway	P00627	ERK1-2	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00205	GAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	2574500	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	ISS	15313841	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00787	MAPKK4	BOVIN|Ensembl=ENSBTAG00000012103|UniProtKB=A5PJP8	MAP2K4 protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00029	Huntington disease	P00807	Actin	ARATH|TAIR=AT2G42090|UniProtKB=P93738	Putative actin-9	IDA	10974003	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00006	Apoptosis signaling pathway	P00302	ATF	HUMAN|HGNC=783|UniProtKB=P18846	Cyclic AMP-dependent transcription factor ATF-1	ISS	11390664	PubMed	PTHR22952:SF258	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00056	VEGF signaling pathway	P01423	p38MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	CAEEL|WormBase=WBGene00004769|UniProtKB=P52166	Presenilin sel-12	TAS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00029	Huntington disease	P00774	Dynein complex	HUMAN|HGNC=2950|UniProtKB=Q8TE73	Dynein heavy chain 5, axonemal	IPI	9454836	PubMed	PTHR10676:SF240	DYNEIN HEAVY CHAIN 5, AXONEMAL
P05915	Opioid proenkephalin pathway	P05990	K+ channel	PANTR|Ensembl=ENSPTRG00000020614|UniProtKB=H2QWR7	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	XENTR|Xenbase=XB-GENE-956713|UniProtKB=Q5XGD8	Guanine nucleotide binding protein, beta 3	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P02744	Fructose galactose metabolism	P02965	UDP Glucose 4 epimerase	PHYIT|EnsemblGenome=PITG_16865|UniProtKB=D0NUA3	Aldose 1-epimerase, putative	ISS			PTHR10091:SF0	ALDOSE 1-EPIMERASE
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	ORNAN|Ensembl=ENSOANG00000012116|UniProtKB=F7F9P9	Uncharacterized protein	ISS			PTHR12458:SF8	CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02738	De novo purine biosynthesis	P02889	dGDP kinase	PANTR|Ensembl=ENSPTRG00000005528|UniProtKB=H2Q705	Nucleoside diphosphate kinase	ISS			PTHR11349:SF68	NUCLEOSIDE DIPHOSPHATE KINASE-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000013587|UniProtKB=F7AZ16	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF33	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-3
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P06664	Gonadotropin-releasing hormone receptor pathway	P06757	JUN	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	RCA	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02748	Isoleucine biosynthesis	P02997	Acetolactate synthase	METAC|EnsemblGenome=MA_1958|UniProtKB=Q8TPF5	Acetolactate synthase	ISS			PTHR18968:SF129	SUBFAMILY NOT NAMED
P00009	Axon guidance mediated by netrin	P00363	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00047	PDGF signaling pathway	P01174	Rho	MACMU|Ensembl=ENSMMUG00000006528|UniProtKB=F7H6M3	Rho GTPase-activating protein 15	ISS	8288572	PubMed	PTHR23181:SF5	RHO GTPASE-ACTIVATING PROTEIN 15
P05915	Opioid proenkephalin pathway	P05985	Mu or Delta receptor	MOUSE|MGI=MGI=97441|UniProtKB=P42866	Mu-type opioid receptor	RCA	11259498	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	IDA	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	MOUSE|MGI=MGI=1309489|UniProtKB=O70589	Peripheral plasma membrane protein CASK	IDA	11430913	PubMed	PTHR23122:SF40	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DICDI|dictyBase=DDB_G0275023|UniProtKB=Q553U6	Putative actin-22	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00021	FGF signaling pathway	P00628	JNK1-3	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	HUMAN|HGNC=5294|UniProtKB=P41595	5-hydroxytryptamine receptor 2B	ISS	11859080	PubMed	PTHR24247:SF31	5-HYDROXYTRYPTAMINE RECEPTOR 2B
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	PANTR|Ensembl=ENSPTRG00000003839|UniProtKB=H2Q401	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF41	RIBOSOMAL PROTEIN S6 KINASE ALPHA-4
P00056	VEGF signaling pathway	P01411	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MACMU|Ensembl=ENSMMUG00000003354|UniProtKB=F7ED17	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF160	GROWTH/DIFFERENTIATION FACTOR 7
P04393	Ras Pathway	P04570	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01199	Galpha	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00012	Cadherin signaling pathway	P00470	F-actin	MACMU|Ensembl=ENSMMUG00000007027|UniProtKB=F7F210	Alpha-cardiac actin	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00059	p53 pathway	P04611	P300	BOVIN|Ensembl=ENSBTAG00000016198|UniProtKB=E1B8D6	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00018	EGF receptor signaling pathway	G01511	SPRY	MOUSE|MGI=MGI=1345139|UniProtKB=Q9QXV9	Protein sprouty homolog 1	IGI	12882970	PubMed	PTHR12365:SF10	PROTEIN SPROUTY HOMOLOG 1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P06664	Gonadotropin-releasing hormone receptor pathway	P06710	Junc	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	RCA	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	PANTR|Ensembl=ENSPTRG00000007489|UniProtKB=H2QA49	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1203729|UniProtKB=Q61194	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00025	Hedgehog signaling pathway	P00699	Su(fu)	DROME|FlyBase=FBgn0005355|UniProtKB=Q9VG38	Suppressor of fused homolog	IDA	1468628	PubMed	PTHR10928:SF2	SUPPRESSOR OF FUSED HOMOLOG
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00004	Alzheimer disease-presenilin pathway	P00114	actin	HUMAN|HGNC=144|UniProtKB=P63261	Actin, cytoplasmic 2	IDA	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00010	B cell activation	P00384	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	YEAST|SGD=S000000028|UniProtKB=P31109	Synaptobrevin homolog 1	IC			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00017	DNA replication	P00527	Histones	SCLS1|EnsemblGenome=SS1G_09608|UniProtKB=A7EW99	Histone H3	ISS	12413958	PubMed	PTHR11426:SF169	HISTONE H3
P00010	B cell activation	P00392	I kappa B	BOVIN|Ensembl=ENSBTAG00000016683|UniProtKB=Q8WNW7	NF kappa B inhibitor alpha (Fragment)	ISS	14665694	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	TAS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	HUMAN|HGNC=16767|UniProtKB=Q8TCU5	Glutamate receptor ionotropic, NMDA 3A	IC	11554549	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00010	B cell activation	P00384	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IDA	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04380	Cortocotropin releasing factor receptor signaling pathway	P04453	ACTH	MOUSE|MGI=MGI=97742|UniProtKB=P01193	Pro-opiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00059	p53 pathway	G01576	14-3-3	MACMU|Ensembl=ENSMMUG00000013855|UniProtKB=F6RM85	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF14	14-3-3 PROTEIN SIGMA
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00715	AGS3	HUMAN|HGNC=17858|UniProtKB=Q86YR5	G-protein-signaling modulator 1	ISS	11121039	PubMed	PTHR10098:SF36	G-PROTEIN-SIGNALING MODULATOR 1
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P06216	SCW signaling pathway	P06332	PPM1A	DROME|FlyBase=FBgn0086361|UniProtKB=Q961C5	Alphabet, isoform E	IEA	http://flybase.org/reports/FBgn0086361.html	Website	PTHR13832:SF524	PROTEIN PHOSPHATASE 1A, MAGNESIUM DEPENDENT, ALPHA ISOFORM-RELATED
P00053	T cell activation	P01300	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00006	Apoptosis signaling pathway	P00301	Apaf-1	PANTR|Ensembl=ENSPTRG00000005335|UniProtKB=H2R1S6	Apoptotic protease-activating factor 1	ISS	9267021	PubMed	PTHR22845:SF5	APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P02736	Coenzyme A biosynthesis	P02885	Pantothenate kinase	ARATH|TAIR=AT4G32180|UniProtKB=Q8L5Y9	Pantothenate kinase 2	ISS			PTHR12280:SF20	PANTOTHENATE KINASE 4
P00053	T cell activation	P01311	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	IDA	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MACMU|Ensembl=ENSMMUG00000006253|UniProtKB=F7H582	Uncharacterized protein	ISS	93028552	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00034	Integrin signalling pathway	P00927	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01332	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02728	Arginine biosynthesis	P02846	Ornithine carbamoyl transferase	SCHPO|PomBase=SPAC4G9.10|UniProtKB=P31317	Ornithine carbamoyltransferase, mitochondrial	ISS			PTHR11405:SF1	ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	BOVIN|Ensembl=ENSBTAG00000007517|UniProtKB=F1MUN1	Uncharacterized protein	ISS	15155845	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P00034	Integrin signalling pathway	P00916	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00060	Ubiquitin proteasome pathway	P01492	E1	CAEEL|WormBase=WBGene00000142|UniProtKB=Q17820	SUMO-activating enzyme subunit aos-1	ISS			PTHR10953:SF162	SUMO-ACTIVATING ENZYME SUBUNIT 1
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	RAT|RGD=2736|UniProtKB=P35439	Glutamate receptor ionotropic, NMDA 1	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P02785	Valine biosynthesis	P03215	Branched chain amino acid aminotransferase	RAT|RGD=68948|UniProtKB=O35854	Branched-chain-amino-acid aminotransferase, mitochondrial	ISS			PTHR11825:SF39	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, MITOCHONDRIAL
P00006	Apoptosis signaling pathway	P00269	MAPK	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00053	T cell activation	P01324	rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12176041	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00048	PI3 kinase pathway	P01199	Galpha	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05730	Endogenous cannabinoid signaling	P05746	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05913	Enkephalin release	G06045	preproenkephalin	BOVIN|Ensembl=ENSBTAG00000004924|UniProtKB=P01211	Proenkephalin-A	IC	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00005	Angiogenesis	P00207	Crk	CHICK|Ensembl=ENSGALG00000006390|UniProtKB=F1P241	Uncharacterized protein	ISS	8649368	PubMed	PTHR19969:SF9	CRK-LIKE PROTEIN
P00059	p53 pathway	P04625	Cdk2	PANTR|Ensembl=ENSPTRG00000005070|UniProtKB=H2Q670	Cyclin-dependent kinase 2	ISS	1846803	PubMed	PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8655|UniProtKB=Q08174	Protocadherin-1	IDA	8120095	PubMed	PTHR43912:SF3	PROTOCADHERIN-1
P05917	Opioid proopiomelanocortin pathway	P06004	Mu or Delta receptor	BOVIN|Gene=OPRM1|UniProtKB=P79350	Mu-type opioid receptor	RCA	11259498	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00005	Angiogenesis	P00249	PAK	CHICK|Ensembl=ENSGALG00000000681|UniProtKB=E1C3P6	Uncharacterized protein	ISS	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	ISS	12169092	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00018	EGF receptor signaling pathway	P00543	ERK1-2	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IGI	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04398	p53 pathway feedback loops 2	P04651	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00021	FGF signaling pathway	P00642	MEK1-2	CAEBR|Gene=CBG04190|UniProtKB=A8WWD7	Protein CBR-MEK-2	ISS	17508425	gi	PTHR24361:SF629	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1
P00047	PDGF signaling pathway	P01152	RasGAP	DROME|FlyBase=FBgn0004390|UniProtKB=P48423	GTPase-activating protein	ISS	92191280	PubMed	PTHR10194:SF126	GTPASE-ACTIVATING PROTEIN
P04397	p53 pathway by glucose deprivation	P04641	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01230	Src kinase	PANTR|Ensembl=ENSPTRG00000018511|UniProtKB=H2QTK7	Tyrosine-protein kinase	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00225	MEK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS			PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05913	Enkephalin release	P05974	G-Protein (i)	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P05916	Opioid prodynorphin pathway	P06002	G-protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00047	PDGF signaling pathway	P01171	PLCgamma	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CAEEL|WormBase=WBGene00001187|UniProtKB=Q8MQA1	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00048	PI3 kinase pathway	P01188	Gbetagamma	PHYIT|EnsemblGenome=PITG_06376|UniProtKB=D0N4Q3	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta, putative	IC	12081467	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DANRE|ZFIN=ZDB-GENE-030131-1229|UniProtKB=Q6DHS1	Actin, alpha 2, smooth muscle, aorta	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CANLF|Ensembl=ENSCAFG00000008756|UniProtKB=F2Z4N8	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P02785	Valine biosynthesis	P03215	Branched chain amino acid aminotransferase	ANOGA|EnsemblGenome=AGAP000011|UniProtKB=Q7QEI9	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF44	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P00023	General transcription regulation	P00658	TBP-associated factors	MOUSE|MGI=MGI=1913714|UniProtKB=Q8VE65	Transcription initiation factor TFIID subunit 12	ISS			PTHR12264:SF21	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	SCLS1|EnsemblGenome=SS1G_03482|UniProtKB=A7EDU2	Guanine nucleotide-binding protein beta subunit	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00029	Huntington disease	P00790	beta-Tubulin	STRPU|EnsemblGenome=SPU_002788|UniProtKB=W4XHC0	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00021	FGF signaling pathway	P00635	FRS2	PANTR|Ensembl=ENSPTRG00000005207|UniProtKB=H2Q6G0	Fibroblast growth factor receptor substrate 2	ISS	12571252	PubMed	PTHR21258:SF40	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2
P00021	FGF signaling pathway	P00624	14-3-3	XENTR|Xenbase=XB-GENE-996375|UniProtKB=F7DY42	Uncharacterized protein	ISS	98119747	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00034	Integrin signalling pathway	P00936	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IPI	96009592	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEEL|WormBase=WBGene00004033|UniProtKB=P90980	Protein kinase C-like 2	ISS	15572354	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00036	Interleukin signaling pathway	P00965	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00036	Interleukin signaling pathway	P00985	PDK1/2	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	ISS	11256888	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04395	Vasopressin synthesis	P04596	Endo Peptidase	MACMU|Ensembl=ENSMMUG00000006311|UniProtKB=F6ZSA4	Prolyl endopeptidase-like isoform 1	ISS			PTHR11757:SF12	PROLYL ENDOPEPTIDASE-LIKE
P00012	Cadherin signaling pathway	P00474	Wnt	DANRE|ZFIN=ZDB-GENE-980526-352|UniProtKB=P47793	Protein Wnt-4a	IDA	8717036	PubMed	PTHR12027:SF103	PROTEIN WNT-4A
P05918	p38 MAPK pathway	P06043	ASK1	HUMAN|HGNC=6857|UniProtKB=Q99683	Mitogen-activated protein kinase kinase kinase 5	TAS	12566458	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P04393	Ras Pathway	P04567	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00046	Oxidative stress response	P01135	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00020	FAS signaling pathway	P00615	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00012	Cadherin signaling pathway	P00467	alpha-catenin	MOUSE|MGI=MGI=88275|UniProtKB=Q61301	Catenin alpha-2	ISS	1638632	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DANRE|ZFIN=ZDB-GENE-081124-1|UniProtKB=F1QVX3	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF728	MYOSIN HEAVY CHAIN, SKELETAL MUSCLE, ADULT
P00047	PDGF signaling pathway	P01143	ERK	BOVIN|Ensembl=ENSBTAG00000005865|UniProtKB=G5E577	Uncharacterized protein	ISS	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MOUSE|MGI=MGI=2150393|UniProtKB=Q91ZU9	Glutamate receptor ionotropic, NMDA 3B	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P00047	PDGF signaling pathway	P01159	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00052	TGF-beta signaling pathway	P01279	Smurfs	DANRE|ZFIN=ZDB-GENE-040426-2744|UniProtKB=F1QEG9	Uncharacterized protein	ISS	11252892	PubMed	PTHR11254:SF293	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=1306541|UniProtKB=D3ZVF3	Phosphoinositide-3-kinase, class 2, beta polypeptide (Predicted)	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_59367|UniProtKB=E9H7Z0	Guanine nucleotide-binding protein G(O) subunit alpha 1	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00323	Bcl-xS	HUMAN|HGNC=992|UniProtKB=Q07817	Bcl-2-like protein 1	RCA			PTHR11256:SF12	BCL-2-LIKE PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	IDA	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P00057	Wnt signaling pathway	P01452	NFAT	HUMAN|HGNC=7777|UniProtKB=Q12968	Nuclear factor of activated T-cells, cytoplasmic 3	IDA	12015605	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00059	p53 pathway	P04630	PP2A	TAKRU|Ensembl=ENSTRUG00000011169|UniProtKB=H2TU36	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01408	Akt/PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01438	PP2A	BOVIN|Ensembl=ENSBTAG00000005533|UniProtKB=F1N1S8	Uncharacterized protein	ISS	12110603	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00053	T cell activation	P01295	vav	HUMAN|HGNC=12659|UniProtKB=Q9UKW4	Guanine nucleotide exchange factor VAV3	IDA	14623913	PubMed	PTHR22826:SF97	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3
P00009	Axon guidance mediated by netrin	P00357	Netrin	PANTR|Ensembl=ENSPTRG00000008752|UniProtKB=H2QC90	Uncharacterized protein	ISS	11356879	PubMed	PTHR10574:SF365	NETRIN-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	DANRE|ZFIN=ZDB-GENE-990415-199|UniProtKB=A3QJX7	Uncharacterized protein	IDA	11259487	PubMed	PTHR24229:SF74	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	14744428	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00007	Axon guidance mediated by semaphorins	P00340	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02724	Alanine biosynthesis	P02815	Branched chain amino acid aminotransferase	PYRAE|EnsemblGenome=PAE3297|UniProtKB=Q8ZTE2	Branched-chain amino acid aminotransferase (IlvE)	ISS			PTHR42743:SF3	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE-LIKE PROTEIN 1-RELATED
P00005	Angiogenesis	P00201	FVIIa	HUMAN|HGNC=3544|UniProtKB=P08709	Coagulation factor VII	IDA	4503645	gi	PTHR44064:SF1	COAGULATION FACTOR VII
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000005903|UniProtKB=F1N1K8	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	RAT|RGD=620770|UniProtKB=P82471	Guanine nucleotide-binding protein G(q) subunit alpha	RCA			PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00036	Interleukin signaling pathway	P00990	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00054	Toll receptor signaling pathway	P01375	JNK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MACMU|Ensembl=ENSMMUG00000017683|UniProtKB=F6UA63	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00012	Cadherin signaling pathway	P00462	Casein kinase II	TAKRU|Ensembl=ENSTRUG00000016144|UniProtKB=H2UWE3	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00053	T cell activation	P01303	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12186904	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00005	Angiogenesis	P00200	Dsh	RAT|RGD=1308834|UniProtKB=D4ADV8	Protein Dvl3	ISS	11212302	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00558	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IGI	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00034	Integrin signalling pathway	P00922	Collagen	MACMU|Ensembl=ENSMMUG00000013233|UniProtKB=F6XE65	Uncharacterized protein	ISS	10778855	PubMed	PTHR24023:SF714	COLLAGEN ALPHA-4 IV  CHAIN
P00021	FGF signaling pathway	P00624	14-3-3	ORNAN|Ensembl=ENSOANG00000007305|UniProtKB=F6XW91	Uncharacterized protein	ISS	12865427	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00475	Frizzled	MOUSE|MGI=MGI=108520|UniProtKB=Q61088	Frizzled-4	IDA	8717036	PubMed	PTHR11309:SF23	FRIZZLED-4
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT2G18170|UniProtKB=Q39027	Mitogen-activated protein kinase 7	ISS	9836510	gi	PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P02741	Flavin biosynthesis	P02939	Lumazine synthase	STRCO|EnsemblGenome=CAC17558|UniProtKB=Q9EWJ9	6,7-dimethyl-8-ribityllumazine synthase	ISS			PTHR21058:SF0	6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE
P06587	Nicotine pharmacodynamics pathway	P06594	CHRNA4	HUMAN|HGNC=1958|UniProtKB=P43681	Neuronal acetylcholine receptor subunit alpha-4	TAS	17597586	PubMed	PTHR18945:SF401	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4
P04398	p53 pathway feedback loops 2	P04661	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	BOVIN|Ensembl=ENSBTAG00000008026|UniProtKB=P01175	Oxytocin-neurophysin 1	ISS	6717565	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	IXOSC|EnsemblGenome=ISCW020797|UniProtKB=B7PXS3	Kynurenine aminotransferase, putative (Fragment)	ISS			PTHR11751:SF306	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04566	Stat 1/3	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	14984365	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04578	Rho	CHICK|Ensembl=ENSGALG00000003806|UniProtKB=O93467	GTP-binding protein	ISS	12039949	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	IC	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	HUMAN|HGNC=129|UniProtKB=P68133	Actin, alpha skeletal muscle	IEP	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00053	T cell activation	P01330	IKK	HUMAN|HGNC=5960|UniProtKB=O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	IGI	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00034	Integrin signalling pathway	P00935	ILK	CHICK|Ensembl=ENSGALG00000017335|UniProtKB=F1NP98	Uncharacterized protein	ISS			PTHR44344:SF1	INTEGRIN-LINKED PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	RAT|RGD=2353|UniProtKB=P09660	Acetylcholine receptor subunit epsilon	IC			PTHR18945:SF59	ACETYLCHOLINE RECEPTOR SUBUNIT EPSILON
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ARATH|TAIR=AT5G19990|UniProtKB=Q9C5U3	26S protease regulatory subunit 8 homolog A	ISS			PTHR23073:SF12	26S PROTEASE REGULATORY SUBUNIT 8
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02752	Mannose metabolism	P03018	Mannose 1-P guanylyl transferase	BOVIN|Ensembl=ENSBTAG00000002995|UniProtKB=E1BEN4	Uncharacterized protein	ISS	12477932	PubMed	PTHR22572:SF104	MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE ALPHA
P00047	PDGF signaling pathway	P01171	PLCgamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00006	Apoptosis signaling pathway	P00269	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00009	Axon guidance mediated by netrin	P00359	NFAT	PANTR|Ensembl=ENSPTRG00000006218|UniProtKB=H2Q834	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00034	Integrin signalling pathway	P00916	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P04393	Ras Pathway	P04559	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IGI	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00035	Interferon-gamma signaling pathway	P00954	Interferongamma	MOUSE|MGI=MGI=107656|UniProtKB=P01580	Interferon gamma	TAS	10553079	PubMed	PTHR11419:SF0	INTERFERON GAMMA
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=30035|UniProtKB=Q8WYR1	Phosphoinositide 3-kinase regulatory subunit 5	ISS	12507995	PubMed	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2744|UniProtKB=P31422	Metabotropic glutamate receptor 3	IDA	20012997	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00004	Alzheimer disease-presenilin pathway	P00127	APP	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00025	Hedgehog signaling pathway	P00682	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ORNAN|Ensembl=ENSOANG00000000460|UniProtKB=F7F4W9	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00057	Wnt signaling pathway	P01438	PP2A	RAT|RGD=6503746|UniProtKB=Q80W83	Protein LOC100909468	ISS	11531413	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01402	MEK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS			PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=2442792|UniProtKB=Q8BM92	Cadherin-7	ISS	8120095	PubMed	PTHR24027:SF91	CADHERIN-7
P00005	Angiogenesis	P00182	p38MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02732	Coenzyme A linked carnitine metabolism	P02864	L-carnitine dehydratase	CAEEL|WormBase=WBGene00014128|UniProtKB=Q09618	CaiB/baiF CoA-transferase family protein ZK892.4	ISS			PTHR44134:SF1	ALPHA-METHYLACYL-COA RACEMASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	TAS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00021	FGF signaling pathway	P00635	FRS2	CHICK|Ensembl=ENSGALG00000009966|UniProtKB=E1C021	Uncharacterized protein	ISS	12571252	PubMed	PTHR21258:SF40	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2
P00019	Endothelin signaling pathway	P00566	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00034	Integrin signalling pathway	P00944	Actin	BOVIN|Ensembl=ENSBTAG00000005714|UniProtKB=Q3ZC07	Actin, alpha cardiac muscle 1	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00036	Interleukin signaling pathway	P00983	Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	IC	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P02757	O-antigen biosynthesis	P03045	dTDP-glucose 4,6-dehydratase	BACTN|EnsemblGenome=BT_2016|UniProtKB=Q8A670	dTDP-glucose 4,6-dehydratase	ISS			PTHR43000:SF13	SUBFAMILY NOT NAMED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	BOVIN|Ensembl=ENSBTAG00000002144|UniProtKB=Q28044	Beta-2 adrenergic receptor	IDA	12063255	PubMed	PTHR24248:SF21	BETA-2 ADRENERGIC RECEPTOR
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00752	cGMP-gated ion channel	MOUSE|MGI=MGI=1341818|UniProtKB=Q9JJZ8	Cyclic nucleotide-gated cation channel alpha-3	ISS	12432397	PubMed	PTHR10217:SF390	CYCLIC NUCLEOTIDE-GATED CATION CHANNEL ALPHA-3
P05918	p38 MAPK pathway	P06021	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	MACMU|Ensembl=ENSMMUG00000006200|UniProtKB=F7HNS7	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CHICK|Ensembl=ENSGALG00000019382|UniProtKB=E1BWK1	Uncharacterized protein	ISS			PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	IGI	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IC	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	BOVIN|Ensembl=ENSBTAG00000046248|UniProtKB=Q58CQ2	Actin-related protein 2/3 complex subunit 1B	ISS	12963527	gi	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00029	Huntington disease	P00807	Actin	DICPU|Gene=DICPUDRAFT_46519|UniProtKB=F0Z796	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	PANTR|Ensembl=ENSPTRG00000004892|UniProtKB=H2Q5U3	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P04395	Vasopressin synthesis	P04596	Endo Peptidase	ARATH|TAIR=AT5G66960|UniProtKB=Q9FGD4	Prolyl oligopeptidase family protein	IC			PTHR11757:SF6	PROLYL OLIGOPEPTIDASE FAMILY PROTEIN
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00036	Interleukin signaling pathway	P00965	ERK	HUMAN|HGNC=6879|UniProtKB=Q16659	Mitogen-activated protein kinase 6	IC	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	IC	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00010	B cell activation	P00385	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00018	EGF receptor signaling pathway	P00541	Spry	MOUSE|MGI=MGI=1345144|UniProtKB=Q9WTP2	Protein sprouty homolog 4	ISS	12027893	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P00047	PDGF signaling pathway	P01154	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MACMU|Ensembl=ENSMMUG00000019112|UniProtKB=F6T8S6	N-methyl D-aspartate receptor subtype 2B	ISS	11554554	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00029	Huntington disease	P00807	Actin	DANRE|ZFIN=ZDB-GENE-030131-55|UniProtKB=Q6XNL8	Actin	IDA	11889139	PubMed	PTHR11937:SF263	ACTIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	DANRE|ZFIN=ZDB-GENE-051202-2|UniProtKB=Q6ZM67	Uncharacterized protein	ISS	11319238	PubMed	PTHR44391:SF3	SUBFAMILY NOT NAMED
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00005	Angiogenesis	P00221	JNK1	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01451	Galpha	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00053	T cell activation	P01312	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00642	MEK1-2	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05917	Opioid proopiomelanocortin pathway	P06004	Mu or Delta receptor	RAT|RGD=3233|UniProtKB=P33533	Delta-type opioid receptor	RCA	11259498	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	IC	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00021	FGF signaling pathway	P00633	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00018	EGF receptor signaling pathway	P00559	MEK1-2	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IGI	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00638	PLCgamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00877	MLCK	MACMU|Ensembl=ENSMMUG00000019786|UniProtKB=F7G5G3	Uncharacterized protein	ISS	600922	OMIM	PTHR45411:SF1	MYOSIN LIGHT CHAIN KINASE 3
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8708|UniProtKB=Q9Y5G3	Protocadherin gamma-B1	IDA	8120095	PubMed	PTHR24028:SF106	PROTOCADHERIN GAMMA-B1-RELATED
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BOVIN|Gene=ACTG2|UniProtKB=Q5E9B5	Actin, gamma-enteric smooth muscle	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IDA	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000003236|UniProtKB=F7DNS6	Uncharacterized protein	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	MACMU|Ensembl=ENSMMUG00000003145|UniProtKB=F7EPF6	Uncharacterized protein	ISS	12374786	PubMed	PTHR11767:SF52	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 4
P00006	Apoptosis signaling pathway	P00269	MAPK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	PANTR|Ensembl=ENSPTRG00000010252|UniProtKB=H2R3W5	Uncharacterized protein	ISS	9783586	PubMed	PTHR10814:SF4	AMINO-TERMINAL ENHANCER OF SPLIT-RELATED
P00034	Integrin signalling pathway	P00913	Csk	MONDO|Ensembl=ENSMODG00000009310|UniProtKB=F7GJZ7	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00020	FAS signaling pathway	P00615	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CANLF|Ensembl=ENSCAFG00000004930|UniProtKB=E2RFB5	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_125401|UniProtKB=C3ZTX6	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00036	Interleukin signaling pathway	P00990	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	SULSO|EnsemblGenome=SSO1930|UniProtKB=Q97X22	Glutamate dehydrogenase	ISS			PTHR11606:SF13	GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MACMU|Ensembl=ENSMMUG00000014807|UniProtKB=F6W548	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8676|UniProtKB=Q9H158	Protocadherin alpha-C1	IDA	8120095	PubMed	PTHR24028:SF153	PROTOCADHERIN ALPHA-C1
P00020	FAS signaling pathway	P00608	Pro-Caspase3	DANRE|ZFIN=ZDB-GENE-011210-1|UniProtKB=B8JK21	Uncharacterized protein	IGI	9323209	PubMed	PTHR10454:SF198	CASPASE-3
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00056	VEGF signaling pathway	P01407	Erk	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	BOVIN|Ensembl=ENSBTAG00000011224|UniProtKB=Q0VCT9	Cbp/p300-interacting transactivator 2	ISS	9865691	PubMed	PTHR17045:SF7	CBP/P300-INTERACTING TRANSACTIVATOR 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05934	ELK1	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	RCA	12660819	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000007996|UniProtKB=E1BE22	Uncharacterized protein	ISS			PTHR24247:SF114	5-HYDROXYTRYPTAMINE RECEPTOR 6
P00029	Huntington disease	P00786	ARF	CANLF|Ensembl=ENSCAFG00000006992|UniProtKB=E2RG67	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P05730	Endogenous cannabinoid signaling	P05751	Galpha	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	G04702	p53	MACMU|Ensembl=ENSMMUG00000016466|UniProtKB=F7GBH1	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	RAT|RGD=3696|UniProtKB=P51907	Excitatory amino acid transporter 3	ISS	94365697	PubMed	PTHR11958:SF69	EXCITATORY AMINO ACID TRANSPORTER 3
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	MACMU|Ensembl=ENSMMUG00000016328|UniProtKB=F7GSV7	Uncharacterized protein	ISS	608986	OMIM	PTHR22952:SF100	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3
P00011	Blood coagulation	P00418	Fibrin monomer	CHICK|Gene=FGA|UniProtKB=P14448	Fibrinogen alpha chain	ISS	1706798	gi	PTHR19143:SF232	FIBRINOGEN ALPHA CHAIN
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	MOUSE|MGI=MGI=2672844|UniProtKB=Q8CIX8	Lengsin	ISS			PTHR43407:SF1	LENGSIN
P04393	Ras Pathway	P04546	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00029	Huntington disease	P00805	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IDA	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04578	Rho	MONDO|Ensembl=ENSMODG00000000981|UniProtKB=F7ES59	Uncharacterized protein	ISS	14871999	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P02728	Arginine biosynthesis	P02846	Ornithine carbamoyl transferase	ORNAN|Ensembl=ENSOANG00000007118|UniProtKB=F6QRQ6	Uncharacterized protein	ISS			PTHR11405:SF1	ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL
P00022	General transcription by RNA polymerase I	P00657	TBP	BOVIN|Ensembl=ENSBTAG00000035370|UniProtKB=Q32LB1	TATA box-binding protein-like protein 1	ISS	10082669	PubMed	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P06664	Gonadotropin-releasing hormone receptor pathway	P06760	MKK4/7	MOUSE|MGI=MGI=1346869|UniProtKB=P47809	Dual specificity mitogen-activated protein kinase kinase 4	RCA	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	BOVIN|Ensembl=ENSBTAG00000013632|UniProtKB=E1B965	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00048	PI3 kinase pathway	P01177	P110ACT	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00565	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00011	Blood coagulation	P00413	HMWK	MACMU|Ensembl=ENSMMUG00000003700|UniProtKB=F6SG43	Uncharacterized protein	ISS	125507	gi	PTHR13814:SF12	KININOGEN-1
P00010	B cell activation	P00381	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00011	Blood coagulation	P00418	Fibrin monomer	CHICK|Ensembl=ENSGALG00000009268|UniProtKB=E1BV78	Uncharacterized protein	ISS	3641556	gi	PTHR19143:SF338	FIBRINOGEN GAMMA CHAIN
P00021	FGF signaling pathway	P00629	PP2A	ORYSJ|EnsemblGenome=OS02G0224200|UniProtKB=Q0E2P1	Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform	ISS			PTHR11871:SF14	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00634	MEKK1-5	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	ISS	8643568	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	IC	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01465	Ggamma	MOUSE|MGI=MGI=1925616|UniProtKB=Q9JMF3	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13	IDA	10391901	PubMed	PTHR15936:SF2	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-13
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	IDA	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	MOUSE|MGI=MGI=95809|UniProtKB=P23819	Glutamate receptor 2	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00007	Axon guidance mediated by semaphorins	P00332	Fes	BOVIN|Ensembl=ENSBTAG00000002941|UniProtKB=Q5E9H3	Tyrosine-protein kinase	ISS			PTHR24418:SF197	TYROSINE-PROTEIN KINASE FES/FPS
P00003	Alzheimer disease-amyloid secretase pathway	P00094	BACE-1 pro-domain	MONDO|Ensembl=ENSMODG00000013692|UniProtKB=F6QP52	Uncharacterized protein	ISS	10531052	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05916	Opioid prodynorphin pathway	P06002	G-protein	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00049	Parkinson disease	P01230	Src kinase	CANLF|Ensembl=ENSCAFG00000017945|UniProtKB=E2RFF7	Tyrosine-protein kinase	ISS	7687537	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02738	De novo purine biosynthesis	P02889	dGDP kinase	HUMAN|HGNC=7849|UniProtKB=P15531	Nucleoside diphosphate kinase A	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P00046	Oxidative stress response	P01136	Elk-1	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	TAS	11050086	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	CHICK|Ensembl=ENSGALG00000027629|UniProtKB=Q5ZJ03	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=1951|UniProtKB=P08172	Muscarinic acetylcholine receptor M2	IDA	10069496	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MACMU|Ensembl=ENSMMUG00000019977|UniProtKB=F7FSB1	Uncharacterized protein	ISS			PTHR13140:SF575	MYOSIN-15
P00021	FGF signaling pathway	P00627	ERK1-2	ARATH|TAIR=AT1G10210|UniProtKB=Q39021	Mitogen-activated protein kinase 1	ISS			PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00052	TGF-beta signaling pathway	P01288	FKBP12	DROME|FlyBase=FBgn0013954|UniProtKB=P48375	12 kDa FK506-binding protein	ISS			PTHR10516:SF341	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	89107990	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00006	Apoptosis signaling pathway	P00291	MEKK1	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	ISS	12049732	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	PANTR|Ensembl=ENSPTRG00000006510|UniProtKB=H2Q8K1	Presenilin	ISS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00049	Parkinson disease	P01211	ERK	RAT|RGD=621505|UniProtKB=P0C865	Mitogen-activated protein kinase 7	ISS	15085193	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	MONDO|Ensembl=ENSMODG00000018065|UniProtKB=F7G485	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00049	Parkinson disease	P01208	Hsp70	YEAST|SGD=S000000756|UniProtKB=P39987	Heat shock protein SSC3, mitochondrial	IDA	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P00057	Wnt signaling pathway	P01435	SWI/SNF	MACMU|Ensembl=ENSMMUG00000009024|UniProtKB=F7FGM1	Uncharacterized protein	ISS	11532957	PubMed	PTHR10799:SF949	CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1-LIKE
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	HUMAN|HGNC=8528|UniProtKB=P01178	Oxytocin-neurophysin 1	ISS	3768139	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	DROME|FlyBase=FBgn0019947|UniProtKB=O02194	Presenilin homolog	IDA	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00018	EGF receptor signaling pathway	P00563	Gab	PANTR|Ensembl=ENSPTRG00000022447|UniProtKB=H2QZB4	Uncharacterized protein	ISS	11739737	PubMed	PTHR12156:SF2	GRB2-ASSOCIATED-BINDING PROTEIN 3
P04398	p53 pathway feedback loops 2	P04651	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	BACSU|EnsemblGenome=BSU00920|UniProtKB=P22250	Glutamate--tRNA ligase	ISS			PTHR43311:SF2	GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED
P02738	De novo purine biosynthesis	P02893	ATP reductase	FUSNN|EnsemblGenome=FN0311|UniProtKB=Q8RGI2	Anaerobic ribonucleoside-triphosphate reductase	ISS			PTHR21075:SF0	ANAEROBIC RIBONUCLEOSIDE-TRIPHOSPHATE REDUCTASE
P00005	Angiogenesis	P00235	c-Fos	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	IDA	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	DANRE|ZFIN=ZDB-GENE-020125-3|UniProtKB=E7F1V8	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00012	Cadherin signaling pathway	P00473	P120	RAT|RGD=1305643|UniProtKB=D3ZZZ9	Catenin (Cadherin associated protein), delta 1 (Predicted), isoform CRA_a	ISS			PTHR10372:SF6	CATENIN DELTA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00739	AGS3	HUMAN|HGNC=17858|UniProtKB=Q86YR5	G-protein-signaling modulator 1	ISS	11121039	PubMed	PTHR10098:SF36	G-PROTEIN-SIGNALING MODULATOR 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CANLF|Ensembl=ENSCAFG00000015662|UniProtKB=E2RHY4	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	RAT|RGD=1310557|UniProtKB=F1LNW1	Protein Rbpj	ISS	12145413	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	ANOGA|EnsemblGenome=AGAP000445|UniProtKB=Q7PRU8	AGAP000445-PA	IDA	12106606	PubMed	PTHR24246:SF27	ADENOSINE RECEPTOR A2A
P00018	EGF receptor signaling pathway	P00543	ERK1-2	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IGI	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12874273	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00881	ROCK	MONDO|Ensembl=ENSMODG00000021484|UniProtKB=F7G2Y1	Uncharacterized protein	ISS	10779382	PubMed	PTHR22988:SF33	RHO-ASSOCIATED PROTEIN KINASE 1
P00010	B cell activation	P00386	Calcineurin	MOUSE|MGI=MGI=107163|UniProtKB=P48453	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	IDA	12015605	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	PANTR|Ensembl=ENSPTRG00000001638|UniProtKB=H2Q0J3	Adenylate cyclase type 10	ISS	9874775	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00046	Oxidative stress response	P01129	JNK1/2	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01448	CBP	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	IDA	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	HUMAN|HGNC=4573|UniProtKB=P42263	Glutamate receptor 3	ISS	10331083	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00011	Blood coagulation	P00411	PAI-1	PANTR|Ensembl=ENSPTRG00000019519|UniProtKB=H2QV47	Uncharacterized protein	ISS	10692390	PubMed	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05730	Endogenous cannabinoid signaling	P05746	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00015	Circadian clock system	G01497	cry	PANTR|Ensembl=ENSPTRG00000003537|UniProtKB=H2Q3H0	Uncharacterized protein	ISS	14507900	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00048	PI3 kinase pathway	P01192	p110	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00045	Notch signaling pathway	G01541	E(spl)-C genes	MONDO|Ensembl=ENSMODG00000017701|UniProtKB=F7FUU4	Uncharacterized protein	ISS			PTHR10985:SF88	HAIRY/ENHANCER-OF-SPLIT RELATED WITH YRPW MOTIF PROTEIN 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ORYSJ|EnsemblGenome=OS03G0718100|UniProtKB=Q10DV7	Actin-1	IC	14684598	PubMed	PTHR11937:SF364	ACTIN-11
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	NAS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00007	Axon guidance mediated by semaphorins	P00338	Neuropilin 1	MOUSE|MGI=MGI=106206|UniProtKB=P97333	Neuropilin-1	ISS	9288754	PubMed	PTHR44185:SF1	NEUROPILIN-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00223	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00048	PI3 kinase pathway	P01188	Gbetagamma	MACMU|Ensembl=ENSMMUG00000017374|UniProtKB=F7H6T7	Uncharacterized protein	ISS	10051575	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P02738	De novo purine biosynthesis	P02907	dADP kinase	MACMU|Ensembl=ENSMMUG00000000612|UniProtKB=F7CDE0	Nucleoside diphosphate kinase	ISS			PTHR11349:SF49	NUCLEOSIDE DIPHOSPHATE KINASE, MITOCHONDRIAL
P04384	Gamma-aminobutyric acid synthesis	P04480	GABA aminotransferase	RAT|RGD=620948|UniProtKB=P50554	4-aminobutyrate aminotransferase, mitochondrial	RCA			PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	PANTR|Ensembl=ENSPTRG00000003207|UniProtKB=H2Q2Y0	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00059	p53 pathway	G04702	p53	MACMU|Ensembl=ENSMMUG00000008639|UniProtKB=P56424	Cellular tumor antigen p53	TAS	11313951	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02746	Heme biosynthesis	P02979	porphobilinogen synthase	MYCTU|EnsemblGenome=Rv0512|UniProtKB=P9WMP5	Delta-aminolevulinic acid dehydratase	ISS			PTHR11458:SF0	DELTA-AMINOLEVULINIC ACID DEHYDRATASE
P00007	Axon guidance mediated by semaphorins	P00337	Sema3A	ORNAN|Ensembl=ENSOANG00000013046|UniProtKB=F7AVR4	Uncharacterized protein	ISS	8402908	PubMed	PTHR11036:SF23	SEMAPHORIN-3A
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00056	VEGF signaling pathway	P01407	Erk	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	ORYSJ|EnsemblGenome=OS03G0223400|UniProtKB=P14654	Glutamine synthetase cytosolic isozyme 1-2	ISS			PTHR20852:SF78	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	RAT|RGD=1304965|UniProtKB=A0A0G2K6E0	Protein Rhoc	ISS	12090470	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00016	Cytoskeletal regulation by Rho GTPase	P00521	Profilin	CANAL|CGD=CAL0001759|UniProtKB=Q5A786	Profilin	ISS			PTHR11604:SF0	PROFILIN
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	RCA	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g236559|UniProtKB=A7RRG4	Actin-related protein 2/3 complex subunit 4	ISS	5031595	gi	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	CANLF|Gene=PSEN1|UniProtKB=Q6RH31	Presenilin-1	TAS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	MACMU|Ensembl=ENSMMUG00000010707|UniProtKB=F7G8G5	Signal transducer and activator of transcription	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00005	Angiogenesis	P00243	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00475	Frizzled	MOUSE|MGI=MGI=108460|UniProtKB=Q61091	Frizzled-8	IDA	11212302	PubMed	PTHR11309:SF90	FRIZZLED-8
P00047	PDGF signaling pathway	P01151	PKB	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01452	NFAT	MACMU|Ensembl=ENSMMUG00000003370|UniProtKB=F7E8G2	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00046	Oxidative stress response	P01138	MKK4	MOUSE|MGI=MGI=1346869|UniProtKB=P47809	Dual specificity mitogen-activated protein kinase kinase 4	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00047	PDGF signaling pathway	P01151	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	HUMAN|HGNC=4588|UniProtKB=O15399	Glutamate receptor ionotropic, NMDA 2D	IC	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	ORNAN|Ensembl=ENSOANG00000014180|UniProtKB=F6PFR5	Fructose-bisphosphate aldolase (Fragment)	ISS	3105602	PubMed	PTHR11627:SF3	FRUCTOSE-BISPHOSPHATE ALDOLASE C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	MACMU|Ensembl=ENSMMUG00000010707|UniProtKB=F7G8G5	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	ANOGA|EnsemblGenome=AGAP006475|UniProtKB=Q5TQX0	AGAP006475-PA	IDA	4262086	gi	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P02728	Arginine biosynthesis	P02840	Argininosuccinate synthase	PSEAE|EnsemblGenome=PA3525|UniProtKB=Q9HY84	Argininosuccinate synthase	ISS			PTHR11587:SF2	ARGININOSUCCINATE SYNTHASE
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	ASHGO|EnsemblGenome=AGOS_AGL093W|UniProtKB=Q9HF56	Cell division control protein 42	ISS	12932731	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IGI	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00005	Angiogenesis	P00219	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00029	Huntington disease	P00795	BDNF	CHICK|Ensembl=ENSGALG00000012163|UniProtKB=P25429	Brain-derived neurotrophic factor	TAS	11724916	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	9514948	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00019	Endothelin signaling pathway	P00573	signal peptidase	MOUSE|MGI=MGI=1929464|UniProtKB=Q9R0P6	Signal peptidase complex catalytic subunit SEC11A	ISS	2674115	PubMed	PTHR10806:SF8	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11A-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05943	GRK2	BOVIN|Gene=ADRBK1|UniProtKB=P21146	Beta-adrenergic receptor kinase 1	RCA	10852916	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P00029	Huntington disease	P00774	Dynein complex	HUMAN|HGNC=2966|UniProtKB=O43237	Cytoplasmic dynein 1 light intermediate chain 2	IPI	9454836	PubMed	PTHR12688:SF1	CYTOPLASMIC DYNEIN 1 LIGHT INTERMEDIATE CHAIN 2
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	PANTR|Ensembl=ENSPTRG00000002706|UniProtKB=H2Q272	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P00053	T cell activation	P01324	rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	IDA	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	PANTR|Ensembl=ENSPTRG00000005263|UniProtKB=H2Q6J5	Acyl-CoA synthetase short-chain family member 3	ISS			PTHR43347:SF3	ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2520|UniProtKB=P61169	D(2) dopamine receptor	IDA	2137198	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	HUMAN|HGNC=4584|UniProtKB=Q05586	Glutamate receptor ionotropic, NMDA 1	IC	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00053	T cell activation	P01335	jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00018	EGF receptor signaling pathway	P00545	JNK1-3	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BOVIN|Ensembl=ENSBTAG00000013990|UniProtKB=F1MN70	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P00029	Huntington disease	P00775	Rac	ANOGA|EnsemblGenome=AGAP002440|UniProtKB=Q17031	Cdc42 homolog	ISS			PTHR24072:SF192	CDC42 HOMOLOG
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	PANTR|Ensembl=ENSPTRG00000023318|UniProtKB=H2Q4N3	Matrix metallopeptidase 1 (Interstitial collagenase)	ISS	3009463	PubMed	PTHR10201:SF151	INTERSTITIAL COLLAGENASE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CAEBR|Gene=CBG02167|UniProtKB=A8WS37	Protein CBG02167	ISS	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	TAS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00049	Parkinson disease	P01230	Src kinase	TAKRU|Ensembl=ENSTRUG00000003538|UniProtKB=H2S7D1	Tyrosine-protein kinase	ISS	9741627	PubMed	PTHR24418:SF242	TYROSINE-PROTEIN KINASE FYNB
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00045	Notch signaling pathway	G01541	E(spl)-C genes	MOUSE|MGI=MGI=1341800|UniProtKB=Q9WV93	Hairy/enhancer-of-split related with YRPW motif protein 1	IC			PTHR10985:SF78	HAIRY/ENHANCER-OF-SPLIT RELATED WITH YRPW MOTIF PROTEIN 1
P04393	Ras Pathway	P04546	GSK3	BOVIN|Ensembl=ENSBTAG00000020756|UniProtKB=A6QLB8	GSK3A protein	ISS	14698990	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00012	Cadherin signaling pathway	P00474	Wnt	RAT|RGD=69079|UniProtKB=M0R9D3	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	MOUSE|MGI=MGI=102522|UniProtKB=Q8R3Z5	Voltage-dependent L-type calcium channel subunit beta-1	ISS	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00005	Angiogenesis	P00203	Erk	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06959	CCKR signaling map	P07121	MAP2K2	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	RCA	12488236	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	TAS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00048	PI3 kinase pathway	P01198	FOXO	MACMU|Ensembl=ENSMMUG00000020369|UniProtKB=F6UMX8	Uncharacterized protein	ISS	15031210	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00025	Hedgehog signaling pathway	P00691	CBP	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00057	Wnt signaling pathway	P01444	Wnt	CANLF|Ensembl=ENSCAFG00000029321|UniProtKB=J9P5H0	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00024	Glycolysis	P00671	Phosphoglycerate kinase	SYNY3|EnsemblGenome=BAA18521|UniProtKB=P74421	Phosphoglycerate kinase	ISS	97061201	PubMed	PTHR11406:SF11	PHOSPHOGLYCERATE KINASE 1, CHLOROPLASTIC-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	88241036	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02785	Valine biosynthesis	P03216	Acetolactate synthase	SCHPO|PomBase=SPBP35G2.07|UniProtKB=P36620	Acetolactate synthase, mitochondrial	ISS			PTHR18968:SF13	ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL
P05731	GABA-B receptor II signaling	P05760	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00219	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00012	Cadherin signaling pathway	P00477	GSK3beta	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02752	Mannose metabolism	P03018	Mannose 1-P guanylyl transferase	HUMAN|HGNC=22923|UniProtKB=Q96IJ6	Mannose-1-phosphate guanyltransferase alpha	IEA	12477932	PubMed	PTHR22572:SF104	MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE ALPHA
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00018	EGF receptor signaling pathway	P00561	STAT	PANTR|Ensembl=ENSPTRG00000009199|UniProtKB=H2QD19	Signal transducer and activator of transcription	ISS	10835485	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00057	Wnt signaling pathway	P01457	GBeta	DROME|FlyBase=FBgn0001105|UniProtKB=P26308	Guanine nucleotide-binding protein subunit beta-1	IDA	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00010	B cell activation	P00383	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS	9079650	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P04393	Ras Pathway	P04553	PAK	PANTR|Ensembl=ENSPTRG00000015787|UniProtKB=H2QP14	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00047	PDGF signaling pathway	P01148	Grb2	BOVIN|Ensembl=ENSBTAG00000002813|UniProtKB=A6QLU3	GRB2-associated-binding protein 1	ISS			PTHR12156:SF18	GRB2-ASSOCIATED-BINDING PROTEIN 1
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MACMU|Ensembl=ENSMMUG00000016675|UniProtKB=F6VTB5	Uncharacterized protein	ISS	11554549	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00256	PLC-gamma	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	CHICK|Gene=FYN|UniProtKB=Q05876	Tyrosine-protein kinase Fyn	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IDA	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00970	Interleukin	HUMAN|HGNC=6025|UniProtKB=P10145	Interleukin-8	IC	2007144	PubMed	PTHR10179:SF70	INTERLEUKIN-8
P00034	Integrin signalling pathway	P00936	PI3K	CAEEL|WormBase=WBGene00006932|UniProtKB=Q9TXI7	Phosphatidylinositol 3-kinase catalytic subunit type 3	IPI	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00018	EGF receptor signaling pathway	P00547	PP2A	PANTR|Ensembl=ENSPTRG00000017238|UniProtKB=H2QRH7	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04558	p38	DROME|FlyBase=FBgn0024846|UniProtKB=O61443	Mitogen-activated protein kinase 14B	ISS	10851062	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00047	PDGF signaling pathway	P01163	c-Jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04393	Ras Pathway	P04541	p90RSK	CANLF|Ensembl=ENSCAFG00000000828|UniProtKB=F6UWI0	Ribosomal protein S6 kinase	ISS	1922062	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	BOVIN|Ensembl=ENSBTAG00000006495|UniProtKB=P11017	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=3763|UniProtKB=P30680	Somatostatin receptor type 2	IDA	12181435	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P02788	Xanthine and guanine salvage pathway	P03245	Guanine phosphoribosyl transferase	BOVIN|Ensembl=ENSBTAG00000046220|UniProtKB=G3N0T0	Uncharacterized protein	ISS			PTHR43340:SF6	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00005	Angiogenesis	P00206	Wnt	PANTR|Ensembl=ENSPTRG00000004893|UniProtKB=H2Q5U4	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	CHICK|Gene=ADCY9|UniProtKB=Q9DGG6	Adenylate cyclase type 9	IDA	2491850	PubMed	PTHR11920:SF319	ADENYLATE CYCLASE TYPE 9
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05918	p38 MAPK pathway	P06029	p38beta	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	RCA	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00029	Huntington disease	P00799	JNK-2	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Ensembl=ENSGALG00000009844|UniProtKB=P68034	Actin, alpha cardiac muscle 1	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00048	PI3 kinase pathway	P01192	p110	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	IGI	12660731	PubMed	PTHR10048:SF14	PI-3 KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00022	General transcription by RNA polymerase I	P00657	TBP	CHICK|Ensembl=ENSGALG00000013981|UniProtKB=Q9YGV8	TATA box-binding protein-like protein 1	ISS	600075	OMIM	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00034	Integrin signalling pathway	P00916	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P00057	Wnt signaling pathway	P01452	NFAT	RAT|RGD=1310749|UniProtKB=D3Z9H7	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	ISS	9462517	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10755300	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	CANLF|Ensembl=ENSCAFG00000010871|UniProtKB=F1PXA0	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00030	Hypoxia response via HIF activation	P00819	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	DROME|FlyBase=FBgn0264000|UniProtKB=M9PHV5	Glutamate receptor IB, isoform B	ISS	12446127	PubMed	PTHR18966:SF270	GLUTAMATE RECEPTOR 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00010	B cell activation	P00401	jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00006	Apoptosis signaling pathway	P00269	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	IC	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00010	B cell activation	P00373	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00034	Integrin signalling pathway	P00927	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	IGI	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00059	p53 pathway	P04610	Cyclin E	RAT|RGD=2294|UniProtKB=P39949	G1/S-specific cyclin-E1	IDA	12628165	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00029	Huntington disease	P00811	Arp2/3 complex	PANTR|Ensembl=ENSPTRG00000021362|UniProtKB=H2QXW1	Actin-related protein 2/3 complex subunit 5	ISS	12473693	PubMed	PTHR12644:SF2	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5-LIKE PROTEIN
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02783	Tryptophan biosynthesis	P03209	Anthranilate phosphoribosyl transferase	DEIRA|EnsemblGenome=DR_1766|UniProtKB=Q9RTJ6	Anthranilate synthase component 2	ISS			PTHR43418:SF4	MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00047	PDGF signaling pathway	P01168	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04371	5-Hydroxytryptamine biosynthesis	P04400	Aromatic L-amino acid decarboxylase	MACMU|Ensembl=ENSMMUG00000019991|UniProtKB=F7FNW0	Aromatic-L-amino-acid decarboxylase	ISS	7567987	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	HUMAN|HGNC=6153|UniProtKB=P05556	Integrin beta-1	IDA	3487386	PubMed	PTHR10082:SF28	INTEGRIN BETA-1
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MOUSE|MGI=MGI=87902|UniProtKB=P68134	Actin, alpha skeletal muscle	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00049	Parkinson disease	P01230	Src kinase	BOVIN|Ensembl=ENSBTAG00000007932|UniProtKB=F1MWN2	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF245	TYROSINE-PROTEIN KINASE HCK
P00049	Parkinson disease	P01238	14-3-3	MACMU|Ensembl=ENSMMUG00000013206|UniProtKB=F6XFG9	14-3-3 protein beta/alpha	ISS	91108808	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	BOVIN|Ensembl=ENSBTAG00000017017|UniProtKB=Q1RMS2	CTP synthase 2	ISS			PTHR11550:SF2	CTP SYNTHASE 2
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00216	Caspase 9	RAT|RGD=61867|UniProtKB=Q9JHK1	Caspase	ISS	9390557	PubMed	PTHR10454:SF157	CASPASE-9
P04395	Vasopressin synthesis	P04589	Signal Peptidase	DANRE|ZFIN=ZDB-GENE-040718-227|UniProtKB=Q1LVK8	Signal peptidase complex catalytic subunit SEC11	ISS	2092035	PubMed	PTHR10806:SF6	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11
P00017	DNA replication	P00536	DNA Topisomerase	BOVIN|Ensembl=ENSBTAG00000004593|UniProtKB=F1MU48	DNA topoisomerase 2	ISS			PTHR10169:SF36	DNA TOPOISOMERASE 2-BETA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00036	Interleukin signaling pathway	P00973	PKB	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P01481	ATM/ATR	MACMU|Ensembl=ENSMMUG00000004153|UniProtKB=F6XCB4	Uncharacterized protein	ISS	10196661	PubMed	PTHR11139:SF72	SERINE-PROTEIN KINASE ATM
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=1307370|UniProtKB=F1M7E5	Protein Cdh5	ISS	8120095	PubMed	PTHR24027:SF89	CADHERIN-5
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	SCHPO|PomBase=SPAC6G9.11|UniProtKB=Q92356	Synaptobrevin homolog 1	IC			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00012	Cadherin signaling pathway	P00470	F-actin	BOVIN|Ensembl=ENSBTAG00000005714|UniProtKB=Q3ZC07	Actin, alpha cardiac muscle 1	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00010	B cell activation	P00373	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IGI	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00059	p53 pathway	G04694	p110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01421	Rac	HUMAN|HGNC=677|UniProtKB=P85298	Rho GTPase-activating protein 8	ISS			PTHR23176:SF3	PROTEIN PRR5-ARHGAP8-RELATED
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	DANRE|ZFIN=ZDB-GENE-041114-26|UniProtKB=F1RE11	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00269	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00029	Huntington disease	P00811	Arp2/3 complex	HUMAN|HGNC=708|UniProtKB=O15511	Actin-related protein 2/3 complex subunit 5	TAS	12932731	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P04398	p53 pathway feedback loops 2	P04658	PTEN	CAEEL|WormBase=WBGene00000913|UniProtKB=G5EE01	DAF-18	ISS	9885576	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000007882|UniProtKB=G3X7Z2	Uncharacterized protein	ISS	15079861	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P06664	Gonadotropin-releasing hormone receptor pathway	P06850	PKCs(3)	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00054	Toll receptor signaling pathway	P01375	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00019	Endothelin signaling pathway	P00583	cPLA2	MONDO|Ensembl=ENSMODG00000011791|UniProtKB=F7CBU9	Phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	RCA	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	MACMU|Ensembl=ENSMMUG00000014486|UniProtKB=F7GH95	Ras-related protein Rap-1A	ISS	1904317	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00018	EGF receptor signaling pathway	P00558	SOS	DICDI|dictyBase=DDB_G0276019|UniProtKB=Q552M5	Ras guanine nucleotide exchange factor Y	ISS			PTHR23113:SF99	PROTEIN SON OF SEVENLESS
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00034	Integrin signalling pathway	P00927	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	10891487	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=1261834|UniProtKB=O70283	Protein Wnt-2b	IDA	8717036	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05730	Endogenous cannabinoid signaling	P05746	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00030	Hypoxia response via HIF activation	P00814	P300	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	BOVIN|Ensembl=ENSBTAG00000008497|UniProtKB=E1BIV2	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF179	REGULATOR OF G-PROTEIN SIGNALING 14
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	CANLF|Ensembl=ENSCAFG00000000178|UniProtKB=J9P315	Uncharacterized protein	ISS	11907044	PubMed	PTHR44025:SF2	PROLOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1
P05916	Opioid prodynorphin pathway	P06001	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00060	Ubiquitin proteasome pathway	P01490	E3	RAT|RGD=1559986|UniProtKB=D3ZHB7	Protein Ube3c	ISS			PTHR11254:SF357	UBIQUITIN-PROTEIN LIGASE E3C
P00045	Notch signaling pathway	P01101	Su(H)	MONDO|Ensembl=ENSMODG00000000129|UniProtKB=F6YB95	Uncharacterized protein	ISS	12145413	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	IC	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	HUMAN|HGNC=7883|UniProtKB=Q9UM47	Neurogenic locus notch homolog protein 3	IDA	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00047	PDGF signaling pathway	P01140	ELK	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	ISS	11050086	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00049	Parkinson disease	P01238	14-3-3	ANOGA|EnsemblGenome=AGAP001151|UniProtKB=Q7PX08	AGAP001151-PA	ISS	97302963	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00019	Endothelin signaling pathway	P00568	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=19218|UniProtKB=Q86YW0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1	ISS	10934033	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P00048	PI3 kinase pathway	P01194	S6K	HUMAN|HGNC=10436|UniProtKB=P23443	Ribosomal protein S6 kinase beta-1	ISS	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00005	Angiogenesis	P00189	Fzd	MONDO|Ensembl=ENSMODG00000010505|UniProtKB=F7E9U1	Uncharacterized protein (Fragment)	ISS	11212302	PubMed	PTHR11309:SF81	FRIZZLED-1
P00034	Integrin signalling pathway	P00913	Csk	MACMU|Ensembl=ENSMMUG00000015267|UniProtKB=F7GRP2	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00053	T cell activation	P01320	PLC-gamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00038	JAK/STAT signaling pathway	P01027	STAT	BOVIN|Gene=STAT5A|UniProtKB=Q95115	Signal transducer and activator of transcription 5A	ISS	8584036	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01067	AChE	HUMAN|HGNC=108|UniProtKB=P22303	Acetylcholinesterase	IC			PTHR11559:SF356	ACETYLCHOLINESTERASE
P02771	Pyrimidine Metabolism	P03129	Aminotransferase	PANTR|Ensembl=ENSPTRG00000007746|UniProtKB=H2QAJ4	4-aminobutyrate aminotransferase	ISS	2496985	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00014	Cholesterol biosynthesis	P00493	Geranyl trans-transferase	NEUCR|EnsemblGenome=EFNCRG00000004427|UniProtKB=Q92250	Farnesyl pyrophosphate synthase	ISS	O64905	SPACC	PTHR11525:SF0	FARNESYL PYROPHOSPHATE SYNTHASE
P00036	Interleukin signaling pathway	P00981	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	TAS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00047	PDGF signaling pathway	P01154	Ras	DICDI|dictyBase=DDB_G0293434|UniProtKB=P15064	Ras-like protein rasG	ISS	7997267	PubMed	PTHR24070:SF282	RAS GTPASE-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MONDO|Ensembl=ENSMODG00000000771|UniProtKB=F6SSS3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	CAEEL|WormBase=WBGene00004769|UniProtKB=P52166	Presenilin sel-12	TAS	7566091	PubMed	PTHR10202:SF13	PRESENILIN-2
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00036	Interleukin signaling pathway	P00962	ELK	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	IDA	9644975	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00053	T cell activation	P01337	B7	MACMU|Ensembl=ENSMMUG00000016367|UniProtKB=F7HRF2	Uncharacterized protein	IDA	1650475	PubMed	PTHR25466:SF4	T-LYMPHOCYTE ACTIVATION ANTIGEN CD80
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	HUMAN|HGNC=18123|UniProtKB=Q8NER5	Activin receptor type-1C	TAS	9395284	PubMed	PTHR23255:SF58	ACTIVIN RECEPTOR TYPE-1C
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P02738	De novo purine biosynthesis	P02911	N5-carboxyaminoimidazole ribonucleotide mutase	METAC|EnsemblGenome=MA_1376|UniProtKB=Q8TR08	Phosphoribosylaminoimidazole carboxylase	ISS			PTHR23046:SF2	N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE MUTASE
P00048	PI3 kinase pathway	P01179	PKB	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02738	De novo purine biosynthesis	P02889	dGDP kinase	XENTR|Xenbase=XB-GENE-923233|UniProtKB=Q6AZK9	Nucleoside diphosphate kinase	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P00006	Apoptosis signaling pathway	P00321	HSP70	DROME|FlyBase=FBgn0013277|UniProtKB=Q8INI8	Major heat shock 70 kDa protein Ba	ISS	12150907	PubMed	PTHR19375:SF256	HSP70 PROTEIN-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	PANTR|Ensembl=ENSPTRG00000004718|UniProtKB=H2Q5I0	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04397	p53 pathway by glucose deprivation	P04636	S6K	MACMU|Ensembl=ENSMMUG00000005483|UniProtKB=F7G271	Uncharacterized protein	ISS	15116068	PubMed	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	ARATH|TAIR=AT3G61440|UniProtKB=Q9S757	Bifunctional L-3-cyanoalanine synthase/cysteine synthase C1, mitochondrial	ISS			PTHR10314:SF80	BIFUNCTIONAL L-3-CYANOALANINE SYNTHASE/CYSTEINE SYNTHASE C1, MITOCHONDRIAL
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	IDA	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00021	FGF signaling pathway	P00643	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	HUMAN|HGNC=7883|UniProtKB=Q9UM47	Neurogenic locus notch homolog protein 3	IDA	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00391	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	CHICK|Ensembl=ENSGALG00000011558|UniProtKB=F1NWV6	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P04393	Ras Pathway	P04566	Stat 1/3	HUMAN|HGNC=11364|UniProtKB=P40763	Signal transducer and activator of transcription 3	IDA	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00057	Wnt signaling pathway	P01446	Calcineurin	HUMAN|HGNC=9316|UniProtKB=P48454	Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform	IDA	12015605	PubMed	PTHR11668:SF186	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT GAMMA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	1764995	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P02751	Lysine biosynthesis	P03012	N-succinyl-diaminopimelate desuccinylase	PSEAE|EnsemblGenome=PA1162|UniProtKB=Q9I4H5	Succinyl-diaminopimelate desuccinylase	ISS			PTHR43270:SF9	SUCCINYL-DIAMINOPIMELATE DESUCCINYLASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IGI	1170702	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00629	PP2A	ANOGA|EnsemblGenome=AGAP010172|UniProtKB=Q7PD38	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	ISS	9620264	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00048	PI3 kinase pathway	P01185	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00010	B cell activation	P00383	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IDA	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	ECOLI|EcoGene=EG12292|UniProtKB=P37685	Aldehyde dehydrogenase B	IC			PTHR43111:SF1	ALDEHYDE DEHYDROGENASE B
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	NEUCR|EnsemblGenome=EFNCRG00000004240|UniProtKB=Q01386	cAMP-dependent protein kinase regulatory subunit	IC	176892	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P04393	Ras Pathway	P04542	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04393	Ras Pathway	P04557	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	IDA	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00059	p53 pathway	P04633	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01324	rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	10891487	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	IDA	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	DANRE|ZFIN=ZDB-GENE-990415-278|UniProtKB=P43446	Protein Wnt-10a	TAS	11266476	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00005	Angiogenesis	P00206	Wnt	CHICK|Ensembl=ENSGALG00000005123|UniProtKB=Q9DEB8	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00059	p53 pathway	G04694	p110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00568	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P02757	O-antigen biosynthesis	P03050	dTDP-4-dehydrorhamnose reductase	MYCTU|EnsemblGenome=Rv3266c|UniProtKB=P9WH09	dTDP-4-dehydrorhamnose reductase	ISS			PTHR10491:SF4	METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA
P00049	Parkinson disease	P01242	Casein kinase I	RAT|RGD=71098|UniProtKB=P97633	Casein kinase I isoform alpha	IDA	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05915	Opioid proenkephalin pathway	P05994	G-protein	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00059	p53 pathway	P04634	Cdc2	PANTR|Ensembl=ENSPTRG00000005070|UniProtKB=H2Q670	Cyclin-dependent kinase 2	ISS	15660127	PubMed	PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CHICK|Ensembl=ENSGALG00000004083|UniProtKB=Q90855	AMPA receptor GluR1/A	ISS	12871085	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00054	Toll receptor signaling pathway	P01368	MKK2	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	11251832	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04393	Ras Pathway	P04567	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	RAT|RGD=2522|UniProtKB=P30729	D(4) dopamine receptor	IDA	12181435	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00010	B cell activation	P00373	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00021	FGF signaling pathway	P00630	RKIP	ORYSJ|EnsemblGenome=OS06G0157500|UniProtKB=Q8VWH2	Protein HEADING DATE 3B	NAS			PTHR11362:SF9	PROTEIN FLOWERING LOCUS T-RELATED
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	ISS	15860573	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ARATH|TAIR=AT5G09810|UniProtKB=P53492	Actin-7	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=3230|UniProtKB=Q9NYQ7	Cadherin EGF LAG seven-pass G-type receptor 3	IDA	8120095	PubMed	PTHR24026:SF38	CADHERIN EGF LAG SEVEN-PASS G-TYPE RECEPTOR 3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00034	Integrin signalling pathway	P00925	MEK	MOUSE|MGI=MGI=1346868|UniProtKB=O09110	Dual specificity mitogen-activated protein kinase kinase 3	IDA	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00049	Parkinson disease	P01230	Src kinase	MOUSE|MGI=MGI=88169|UniProtKB=P16277	Tyrosine-protein kinase Blk	IDA	11078745	PubMed	PTHR24418:SF181	TYROSINE-PROTEIN KINASE BLK
P00018	EGF receptor signaling pathway	P00563	Gab	HUMAN|HGNC=29573|UniProtKB=Q86SQ0	Pleckstrin homology-like domain family B member 2	ISS			PTHR12156:SF21	PLECKSTRIN HOMOLOGY-LIKE DOMAIN FAMILY B MEMBER 2
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	BOVIN|Gene=SLC18A2|UniProtKB=Q27963	Synaptic vesicular amine transporter	ISS	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00060	Ubiquitin proteasome pathway	P01490	E3	NEUCR|EnsemblGenome=EFNCRG00000004202|UniProtKB=Q1K827	Ubiquitin conjugating enzyme	ISS			PTHR44020:SF2	UBIQUITIN-CONJUGATING ENZYME E2 K
P00010	B cell activation	P00398	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00705	Gsalpha	HUMAN|HGNC=4388|UniProtKB=P38405	Guanine nucleotide-binding protein G(olf) subunit alpha	IDA	14765990	PubMed	PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00047	PDGF signaling pathway	P01152	RasGAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	11847220	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00049	Parkinson disease	P01242	Casein kinase I	BOVIN|Ensembl=ENSBTAG00000019986|UniProtKB=P35508	Casein kinase I isoform delta	ISS	11437445	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00056	VEGF signaling pathway	P01417	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04541	p90RSK	MONDO|Ensembl=ENSMODG00000008086|UniProtKB=F6YJ34	Ribosomal protein S6 kinase	ISS	10480933	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00996	STAT	MONDO|Ensembl=ENSMODG00000014816|UniProtKB=F7CHH2	Signal transducer and activator of transcription	ISS	10835485	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00029	Huntington disease	P00785	Cytochrome c	HUMAN|HGNC=2579|UniProtKB=P08574	Cytochrome c1, heme protein, mitochondrial	ISS	15163634	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00021	FGF signaling pathway	P00645	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00059	p53 pathway	P04623	CBP	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	IDA	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00015	Circadian clock system	G01501	cry	HUMAN|HGNC=2385|UniProtKB=Q49AN0	Cryptochrome-2	IEP	10428031	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00056	VEGF signaling pathway	P01418	Paxillin	CHICK|Gene=PXN|UniProtKB=P49024	Paxillin	ISS	7579684	PubMed	PTHR24216:SF11	PAXILLIN
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00897	SHIP2	MACMU|Ensembl=ENSMMUG00000010451|UniProtKB=F7CRA7	Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2	ISS	9824312	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CANLF|Ensembl=ENSCAFG00000008756|UniProtKB=F2Z4N8	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00011	Blood coagulation	P00418	Fibrin monomer	PANTR|Ensembl=ENSPTRG00000016534|UniProtKB=H2QQB4	Uncharacterized protein	ISS	223002	gi	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00477	GSK3beta	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00056	VEGF signaling pathway	P01408	Akt/PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00942	Fyn	RAT|RGD=2641|UniProtKB=Q62844	Tyrosine-protein kinase Fyn	IPI	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P02785	Valine biosynthesis	P03216	Acetolactate synthase	METJA|EnsemblGenome=MJ_0277|UniProtKB=Q57725	Probable acetolactate synthase large subunit	ISS			PTHR18968:SF13	ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000014733|UniProtKB=F7GVJ2	Uncharacterized protein	ISS	8120095	PubMed	PTHR43956:SF3	CADHERIN-23
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05925	beta-ARR1	CANLF|Ensembl=ENSCAFG00000005415|UniProtKB=F1PQM2	Uncharacterized protein	ISS	4757780	gi	PTHR11792:SF22	BETA-ARRESTIN-1
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	RAT|RGD=2036|UniProtKB=P40146	Adenylate cyclase type 8	IGI	8163524	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	RCA	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00790	beta-Tubulin	HUMAN|HGNC=30829|UniProtKB=Q9BVA1	Tubulin beta-2B chain	TAS	12932731	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05916	Opioid prodynorphin pathway	P06002	G-protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	ISS	8170357	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00006	Apoptosis signaling pathway	P00310	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MOUSE|MGI=MGI=95823|UniProtKB=Q03391	Glutamate receptor ionotropic, NMDA 2D	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2D.html	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	DICDI|dictyBase=DDB_G0292998|UniProtKB=P32252	Ras-like protein rasB	ISS	93205383	PubMed	PTHR24070:SF206	RAS-LIKE PROTEIN RASB
P00029	Huntington disease	P00780	Microtubule	ORYSJ|EnsemblGenome=OS03G0661300|UniProtKB=Q76FS2	Tubulin beta-8 chain	IDA	12932731	PubMed	PTHR11588:SF246	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01448	CBP	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00012	Cadherin signaling pathway	P00470	F-actin	SCLS1|Gene=SS1G_08733|UniProtKB=A7ETS6	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01320	PLC-gamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	MOUSE|MGI=MGI=99460|UniProtKB=Q61982	Neurogenic locus notch homolog protein 3	IDA	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00019	Endothelin signaling pathway	P00577	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IGI	96009592	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	HUMAN|HGNC=6856|UniProtKB=Q9Y6R4	Mitogen-activated protein kinase kinase kinase 4	IGI	602425	OMIM	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P04393	Ras Pathway	P04548	ATF2	HUMAN|HGNC=784|UniProtKB=P15336	Cyclic AMP-dependent transcription factor ATF-2	ISS	10207617	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01160	IP3 receptor	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00007	Axon guidance mediated by semaphorins	P00340	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	RAT|RGD=69430|UniProtKB=P32851	Syntaxin-1A	IC	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Gene=HTR1E|UniProtKB=Q9N2B6	5-hydroxytryptamine receptor 1E (Fragment)	ISS	12441358	PubMed	PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P00006	Apoptosis signaling pathway	P00260	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01149	MNK1/2	HUMAN|HGNC=7110|UniProtKB=Q9BUB5	MAP kinase-interacting serine/threonine-protein kinase 1	ISS	Q9BUB5	SPACC	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00021	FGF signaling pathway	P00629	PP2A	RAT|RGD=620919|UniProtKB=P36876	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform	IGI	12716901	PubMed	PTHR11871:SF2	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B ALPHA ISOFORM
P00046	Oxidative stress response	P01129	JNK1/2	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P06959	CCKR signaling map	G07275	MCL1	HUMAN|HGNC=6943|UniProtKB=Q07820	Induced myeloid leukemia cell differentiation protein Mcl-1	RCA	18719002	PubMed	PTHR11256:SF46	INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN MCL-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	CAEEL|WormBase=WBGene00001681|UniProtKB=P54406	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF3	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	BOVIN|Ensembl=ENSBTAG00000015910|UniProtKB=P53712	Integrin beta-1	ISS	3487386	PubMed	PTHR10082:SF28	INTEGRIN BETA-1
P00046	Oxidative stress response	P01131	MKP5	BOVIN|Ensembl=ENSBTAG00000003966|UniProtKB=Q2T9T7	Dual specificity phosphatase 3	ISS			PTHR10159:SF485	DUAL SPECIFICITY PROTEIN PHOSPHATASE 3
P00058	mRNA splicing	P01473	U6	MACMU|Ensembl=ENSMMUG00000016301|UniProtKB=F7GUG7	Uncharacterized protein	ISS	12875835	PubMed	PTHR14212:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=1753|UniProtKB=P55290	Cadherin-13	IDA	8120095	PubMed	PTHR24027:SF80	CADHERIN-13
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00547	PP2A	CHICK|Ensembl=ENSGALG00000010273|UniProtKB=P48463	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	NAS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00645	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00021	FGF signaling pathway	P00632	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	G04709	MDM-2	HUMAN|HGNC=6974|UniProtKB=O15151	Protein Mdm4	ISS			PTHR13844:SF20	PROTEIN MDM4
P02746	Heme biosynthesis	P02983	Hydroxymethylbilane synthase	MACMU|Ensembl=ENSMMUG00000014866|UniProtKB=F6U3X9	Uncharacterized protein	ISS			PTHR11557:SF0	PORPHOBILINOGEN DEAMINASE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00059	p53 pathway	P04609	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	ISS	7565716	PubMed	PTHR10048:SF14	PI-3 KINASE
P00029	Huntington disease	P00777	CBP	ARATH|TAIR=AT1G67220|UniProtKB=Q9FYH1	Histone acetyltransferase HAC2	IDA	10664585	PubMed	PTHR13808:SF6	HISTONE ACETYLTRANSFERASE HAC2
P00010	B cell activation	P00379	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00019	Endothelin signaling pathway	P00590	IP3 R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	RCA	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00717	Phosphorylase b	MACMU|Ensembl=ENSMMUG00000009199|UniProtKB=F7HK11	Alpha-1,4 glucan phosphorylase	ISS	4318782	PubMed	PTHR11468:SF1	GLYCOGEN PHOSPHORYLASE, BRAIN FORM
P02750	Lipoate_biosynthesis	P03004	Lipoate synthase	YEAST|SGD=S000005722|UniProtKB=P32875	Lipoyl synthase, mitochondrial	ISS			PTHR10949:SF0	LIPOYL SYNTHASE, MITOCHONDRIAL
P00059	p53 pathway	P04623	CBP	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	97442349	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00023	General transcription regulation	P00662	TFIIA complex	MACMU|Ensembl=ENSMMUG00000030838|UniProtKB=F7FZJ9	Uncharacterized protein	ISS			PTHR12694:SF9	PROTEIN STON1-GTF2A1L-RELATED
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DICDI|dictyBase=DDB_G0289811|UniProtKB=Q54GX7	Actin-10	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00034	Integrin signalling pathway	P00936	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	DROME|FlyBase=FBgn0020622|UniProtKB=Q7KTZ2	Pi3K21B, isoform B	ISS	7937853	PubMed	PTHR10155:SF0	PI3K21B, ISOFORM B
P00056	VEGF signaling pathway	P01425	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00944	Actin	ORNAN|Ensembl=ENSOANG00000007581|UniProtKB=F6QWB7	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00048	PI3 kinase pathway	P01192	p110	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00775	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=9098358|UniProtKB=D3ZUH2	Protein LOC103690878	ISS			PTHR19957:SF72	PROTEIN GM379
P00029	Huntington disease	P00796	Kainate receptor	MACMU|Ensembl=ENSMMUG00000017431|UniProtKB=F7HPP3	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CHICK|Gene=CHRM4|UniProtKB=P17200	Muscarinic acetylcholine receptor M4	IDA	10069496	PubMed	PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P05731	GABA-B receptor II signaling	P05754	Ggamma	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	PANTR|Ensembl=ENSPTRG00000016352|UniProtKB=H2QQ05	Uncharacterized protein	ISS	11266476	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	MONDO|Ensembl=ENSMODG00000001626|UniProtKB=F6TN69	Uncharacterized protein (Fragment)	ISS	15226293	PubMed	PTHR13715:SF16	RYANODINE RECEPTOR 3
P00054	Toll receptor signaling pathway	P01352	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	IC	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	TAS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	P01448	CBP	ARATH|TAIR=AT1G16710|UniProtKB=Q9FWQ5	Histone acetyltransferase HAC12	ISS	10823891	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	IDA	9199552	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P02783	Tryptophan biosynthesis	P03210	Indole-3-glycerol phosphate synthase	GLOVI|EnsemblGenome=BAC90497|UniProtKB=Q7NHI0	Indole-3-glycerol phosphate synthase	ISS			PTHR22854:SF2	TRYPTOPHAN BIOSYNTHESIS PROTEIN TRPCF
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CHICK|Ensembl=ENSGALG00000019382|UniProtKB=E1BWK1	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00017	DNA replication	P00535	5' to 3' Exoribonulcease	CANLF|Ensembl=ENSCAFG00000005185|UniProtKB=E2RMS9	Uncharacterized protein	ISS	99339991	PubMed	PTHR12341:SF41	5'-3' EXORIBONUCLEASE 2
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	DROME|FlyBase=FBgn0019947|UniProtKB=O02194	Presenilin homolog	IDA	12369105	PubMed	PTHR10202:SF13	PRESENILIN-2
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IDA	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00053	T cell activation	P01300	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	BOVIN|Ensembl=ENSBTAG00000002081|UniProtKB=A7YWG6	Serine/threonine-protein kinase receptor	ISS	9395284	PubMed	PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01414	PLC-gamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00006	Apoptosis signaling pathway	P00311	GCKR	XENTR|Xenbase=XB-GENE-951441|UniProtKB=F6R1B6	Mitogen-activated protein kinase kinase kinase kinase	ISS			PTHR24361:SF205	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 3
P00054	Toll receptor signaling pathway	P01354	NFkappaB	MOUSE|MGI=MGI=1099800|UniProtKB=Q9WTK5	Nuclear factor NF-kappa-B p100 subunit	ISS	9133421	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00047	PDGF signaling pathway	P01153	GSK3	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00057	Wnt signaling pathway	P01443	Phospholipase C	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04393	Ras Pathway	P04547	Ras	PANTR|Ensembl=ENSPTRG00000004775|UniProtKB=H2Q5M1	Uncharacterized protein	ISS	6287573	PubMed	PTHR24070:SF186	GTPASE KRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	EMENI|EnsemblGenome=CADANIAG00004083|UniProtKB=P50867	Cysteine synthase 1	ISS			PTHR10314:SF159	CYSTEINE SYNTHASE A
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	CAEEL|WormBase=WBGene00000116|UniProtKB=Q18822	ALdehyde deHydrogenase	IC			PTHR43720:SF2	ALDEHYDE DEHYDROGENASE FAMILY 8 MEMBER A1
P00029	Huntington disease	P00775	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00034	Integrin signalling pathway	P00944	Actin	BRAFL|Gene=BRAFLDRAFT_56687|UniProtKB=C3YC50	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00951	Jnk	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00006	Apoptosis signaling pathway	P00288	TNFR1	HUMAN|HGNC=11916|UniProtKB=P19438	Tumor necrosis factor receptor superfamily member 1A	IDA	11861282	PubMed	PTHR23097:SF177	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1A
P00034	Integrin signalling pathway	P00906	Rap1	TAKRU|Ensembl=ENSTRUG00000006464|UniProtKB=H2STT5	Uncharacterized protein	ISS	10476970	PubMed	PTHR24070:SF382	RAS-RELATED PROTEIN RAP-1B
P04398	p53 pathway feedback loops 2	P04653	cdk2	MACMU|Ensembl=ENSMMUG00000018817|UniProtKB=F6ZHC1	Uncharacterized protein	ISS	1846803	PubMed	PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P00018	EGF receptor signaling pathway	P00558	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00013	Cell cycle	P00484	Cyclin D	MOUSE|MGI=MGI=88315|UniProtKB=P30282	G1/S-specific cyclin-D3	IEP	12884287	PubMed	PTHR10177:SF65	G1/S-SPECIFIC CYCLIN-D3
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00047	PDGF signaling pathway	P01174	Rho	HUMAN|HGNC=21030|UniProtKB=Q53QZ3	Rho GTPase-activating protein 15	ISS	8288572	PubMed	PTHR23181:SF5	RHO GTPASE-ACTIVATING PROTEIN 15
P00017	DNA replication	P00533	Pol delta	HUMAN|HGNC=9175|UniProtKB=P28340	DNA polymerase delta catalytic subunit	ISS	3122029	gi	PTHR10322:SF23	DNA POLYMERASE DELTA CATALYTIC SUBUNIT
P00048	PI3 kinase pathway	P01192	p110	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00551	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	CHICK|Ensembl=ENSGALG00000008058|UniProtKB=F1N8W8	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00049	Parkinson disease	P01208	Hsp70	MACMU|Ensembl=ENSMMUG00000005217|UniProtKB=F7C3R1	78 kDa glucose-regulated protein	ISS	10934466	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	RCA	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	RCA	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8677|UniProtKB=Q9Y5I4	Protocadherin alpha-C2	IDA	8120095	PubMed	PTHR24028:SF119	PROTOCADHERIN ALPHA-C2
P00005	Angiogenesis	P00220	c-Jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P05915	Opioid proenkephalin pathway	P05994	G-protein	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00046	Oxidative stress response	P01135	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	TAS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT1G59580|UniProtKB=Q39022	Mitogen-activated protein kinase 2	IDA	15218451	gi	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00020	FAS signaling pathway	P00615	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CANAL|CGD=CAL0064759|UniProtKB=Q5AKX0	Uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02761	Pantothenate biosynthesis	P03067	3-methyl-2-oxobutanoate hydroxymethyltransferase	NEUCR|EnsemblGenome=EFNCRG00000001549|UniProtKB=Q7S084	3-methyl-2-oxobutanoate hydroxymethyltransferase	ISS			PTHR20881:SF0	3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00108	ADAM10	MACMU|Ensembl=ENSMMUG00000017507|UniProtKB=F6V4A7	Uncharacterized protein	ISS	12354787	PubMed	PTHR11905:SF4	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 10
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IDA	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_79607|UniProtKB=C3ZHN4	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00052	TGF-beta signaling pathway	P01284	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00022	General transcription by RNA polymerase I	P00657	TBP	CAEBR|Gene=CBG09138|UniProtKB=A8X861	Protein CBR-TBP-1	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00019	Endothelin signaling pathway	P00590	IP3 R	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	IGI	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00021	FGF signaling pathway	P00629	PP2A	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00475	Frizzled	RAT|RGD=61916|UniProtKB=Q08463	Frizzled-1	IDA	8717036	PubMed	PTHR11309:SF81	FRIZZLED-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00251	cPLA2	XENTR|Xenbase=XB-GENE-5838849|UniProtKB=B1WAZ6	Cytosolic phospholipase A2	ISS			PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	DICDI|dictyBase=DDB_G0267386|UniProtKB=P46794	Cystathionine beta-synthase	ISS			PTHR10314:SF8	CYSTATHIONINE BETA-SYNTHASE-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DICDI|dictyBase=DDB_G0289487|UniProtKB=P07829	Actin-3	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00047	PDGF signaling pathway	P01161	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00019	Endothelin signaling pathway	P00572	MEK	DROME|FlyBase=FBgn0010269|UniProtKB=Q24324	Dual specificity mitogen-activated protein kinase kinase dSOR1	ISS	176872	OMIM	PTHR24361:SF629	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1
P00034	Integrin signalling pathway	P00933	Crk	MOUSE|MGI=MGI=88508|UniProtKB=Q64010	Adapter molecule crk	ISS	8649368	PubMed	PTHR19969:SF8	ADAPTER MOLECULE CRK
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT1G59580|UniProtKB=Q39022	Mitogen-activated protein kinase 2	ISS	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00018	EGF receptor signaling pathway	P00551	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00627	ERK1-2	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	NAS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00034	Integrin signalling pathway	P00914	Filamin	HUMAN|HGNC=3754|UniProtKB=P21333	Filamin-A	IPI	11911837	PubMed	PTHR43998:SF6	FILAMIN-A
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00898	FKHR	HUMAN|HGNC=3821|UniProtKB=O43524	Forkhead box protein O3	ISS	14775847	gi	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00023	General transcription regulation	P00668	TFIIB	DANRE|ZFIN=ZDB-GENE-030131-6248|UniProtKB=Q5TZ89	Uncharacterized protein	ISS	180660	OMIM	PTHR11618:SF4	TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=1338042|UniProtKB=E9PXQ7	Protein Pcdh10	IDA	8120095	PubMed	PTHR24028:SF0	PROTOCADHERIN-10
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	ANOGA|EnsemblGenome=AGAP002578|UniProtKB=F5HKU8	AGAP002578-PB	ISS	8386525	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	RAT|RGD=2742|UniProtKB=P23385	Metabotropic glutamate receptor 1	IDA	8314195	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00029	Huntington disease	P00780	Microtubule	CHICK|Ensembl=ENSGALG00000026802|UniProtKB=G1K338	Uncharacterized protein	IDA	9454836	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P02774	Salvage pyrimidine deoxyribonucleotides	P03147	Thymidine kinase	DICDI|dictyBase=DDB_G0289179|UniProtKB=Q27564	Thymidine kinase 1	ISS			PTHR11441:SF0	THYMIDINE KINASE, CYTOSOLIC
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00057	Wnt signaling pathway	P01431	LRP5/6	CANLF|Ensembl=ENSCAFG00000013324|UniProtKB=F1PCS0	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	TRYB2|Gene=TB927.1.1240|UniProtKB=Q4GZ95	CTP synthase	ISS			PTHR11550:SF0	CTP SYNTHASE
P00029	Huntington disease	P00790	beta-Tubulin	BATDJ|Gene=BATDEDRAFT_15405|UniProtKB=F4NUL6	Alpha-Beta tubulin	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	IDA	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00054	Toll receptor signaling pathway	P01375	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Ensembl=ENSPTRG00000004233|UniProtKB=H2Q4N9	Uncharacterized protein	ISS	12497607	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00011	Blood coagulation	P00411	PAI-1	BOVIN|Ensembl=ENSBTAG00000014465|UniProtKB=P13909	Plasminogen activator inhibitor 1	ISS	129575	gi	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	SCHPO|PomBase=SPAC6G9.11|UniProtKB=Q92356	Synaptobrevin homolog 1	IC			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00052	TGF-beta signaling pathway	P01284	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	TAS	12040174	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04393	Ras Pathway	P04573	Elk-1	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	14670631	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P02788	Xanthine and guanine salvage pathway	P03247	Xanthine phosphoribosyl transferase	DANRE|ZFIN=ZDB-GENE-040426-1918|UniProtKB=Q7ZV49	Hprt1 protein	ISS			PTHR43340:SF6	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	DANRE|ZFIN=ZDB-GENE-081124-1|UniProtKB=F1QVX3	Uncharacterized protein	ISS			PTHR13140:SF728	MYOSIN HEAVY CHAIN, SKELETAL MUSCLE, ADULT
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8661|UniProtKB=Q9HC56	Protocadherin-9	IDA	8120095	PubMed	PTHR43912:SF5	PROTOCADHERIN-9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	RAT|RGD=620351|UniProtKB=P18265	Glycogen synthase kinase-3 alpha	ISS	14698990	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	DANRE|ZFIN=ZDB-GENE-040426-1013|UniProtKB=Q6P0T2	Transcription initiation factor TFIID subunit 8	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00053	T cell activation	P01295	vav	CHICK|Ensembl=ENSGALG00000002699|UniProtKB=F1NG51	Uncharacterized protein	IGI	14623913	PubMed	PTHR22826:SF95	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV2
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00053	T cell activation	P01294	NFAT	MOUSE|MGI=MGI=1920431|UniProtKB=Q8K120	Nuclear factor of activated T-cells, cytoplasmic 4	IGI	12787506	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MONDO|Ensembl=ENSMODG00000014746|UniProtKB=F6YN64	Uncharacterized protein (Fragment)	ISS	12497607	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	MOUSE|MGI=MGI=1201670|UniProtKB=O35226	26S proteasome non-ATPase regulatory subunit 4	ISS	13645506	gi	PTHR10223:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4
P00019	Endothelin signaling pathway	P00587	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	MOUSE|MGI=MGI=106684|UniProtKB=Q8R090	Chromaffin granule amine transporter	ISS	11443533	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00644	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00055	Transcription regulation by bZIP transcription factor	P01391	TFIIFalpha	PANTR|Ensembl=ENSPTRG00000010362|UniProtKB=H2QF47	General transcription factor IIF, polypeptide 1, 74kDa	ISS	12732728	PubMed	PTHR13011:SF0	GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	HUMAN|HGNC=10484|UniProtKB=Q92736	Ryanodine receptor 2	ISS	15858232	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	IC	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00018	EGF receptor signaling pathway	P00552	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01318	PKC-theta	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	PANTR|Gene=CHRNA4|UniProtKB=Q5IS77	Neuronal acetylcholine receptor subunit alpha-4	ISS	17597586	PubMed	PTHR18945:SF401	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04580	TRH Receptor	BOVIN|Ensembl=ENSBTAG00000019997|UniProtKB=O46639	Thyrotropin-releasing hormone receptor	ISS	14599121	PubMed	PTHR24243:SF115	THYROTROPIN-RELEASING HORMONE RECEPTOR
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MONDO|Ensembl=ENSMODG00000013820|UniProtKB=F6SF10	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MOUSE|MGI=MGI=87902|UniProtKB=P68134	Actin, alpha skeletal muscle	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04372	5-Hydroxytryptamine degredation	P04401	Monoamine Oxidase	MOUSE|MGI=MGI=96915|UniProtKB=Q64133	Amine oxidase [flavin-containing] A	ISS	8602220	PubMed	PTHR43563:SF3	AMINE OXIDASE  FLAVIN-CONTAINING  A
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	98189216	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00036	Interleukin signaling pathway	P00965	ERK	HUMAN|HGNC=24667|UniProtKB=Q8TD08	Mitogen-activated protein kinase 15	IC	10851062	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	XENTR|Xenbase=XB-GENE-961764|UniProtKB=F6W3Y0	Uncharacterized protein	ISS	11259591	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_56687|UniProtKB=C3YC50	Putative uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	RAT|RGD=3693|UniProtKB=Q01818	Chromaffin granule amine transporter	ISS	11443533	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	CANAL|CGD=CAL0076631|UniProtKB=Q59TB5	Folylpolyglutamate synthase	ISS			PTHR11136:SF5	FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MOUSE|MGI=MGI=87917|UniProtKB=Q01341	Adenylate cyclase type 6	IDA	2491850	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	SYNY3|Gene=BAA18852|UniProtKB=P74732	Ribonucleoside-diphosphate reductase subunit beta	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	ORNAN|Ensembl=ENSOANG00000000493|UniProtKB=F7EPA8	Uncharacterized protein	ISS	12181435	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00060	Ubiquitin proteasome pathway	P01490	E3	RAT|RGD=1594738|UniProtKB=A0A0G2K612	Protein Smurf1	ISS	11252892	PubMed	PTHR11254:SF293	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00047	PDGF signaling pathway	P01151	PKB	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01411	Ras	CHICK|Ensembl=ENSGALG00000014033|UniProtKB=E1BTS2	Uncharacterized protein	ISS	3023884	PubMed	PTHR24070:SF186	GTPASE KRAS
P00029	Huntington disease	P00775	Rac	HUMAN|HGNC=17736|UniProtKB=P17081	Rho-related GTP-binding protein RhoQ	TAS	12932731	PubMed	PTHR24072:SF13	RHO-RELATED GTP-BINDING PROTEIN RHOQ
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04398	p53 pathway feedback loops 2	G04708	WIP-1	MOUSE|MGI=MGI=1858214|UniProtKB=Q9QZ67	Protein phosphatase 1D	ISS			PTHR13832:SF359	PROTEIN PHOSPHATASE 1D
P00029	Huntington disease	P00777	CBP	ARATH|TAIR=AT3G12980|UniProtKB=Q9LE42	Histone acetyltransferase HAC5	IDA	10823891	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00021	FGF signaling pathway	P00632	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00059	p53 pathway	G04694	p110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00796	Kainate receptor	HUMAN|HGNC=4580|UniProtKB=Q13002	Glutamate receptor ionotropic, kainate 2	IDA	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04542	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	PANTR|Ensembl=ENSPTRG00000000843|UniProtKB=H2QZN8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00012	Cadherin signaling pathway	P00477	GSK3beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00050	Plasminogen activating cascade	P01255	Plasminogen	PANTR|Ensembl=ENSPTRG00000018774|UniProtKB=H2QU06	Plasminogen	ISS	130317	gi	PTHR24261:SF6	PLASMINOGEN
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	BOVIN|Ensembl=ENSBTAG00000018445|UniProtKB=E1BK87	Uncharacterized protein	ISS	11554554	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	TAS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	CHICK|Ensembl=ENSGALG00000012894|UniProtKB=P30372	Muscarinic acetylcholine receptor M2	TAS	12181435	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00840	GPRK	MACMU|Ensembl=ENSMMUG00000019817|UniProtKB=F7FY63	Protein-serine/threonine kinase	ISS	12032308	PubMed	PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IGI	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	CAEBR|Gene=CBG15746|UniProtKB=A8XMP5	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01444	Wnt	BOVIN|Ensembl=ENSBTAG00000001668|UniProtKB=F1N6L8	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P02723	Adenine and hypoxanthine salvage pathway	P02812	Deoxyinosine phosphorylase	STRCO|Gene=CAD30908|UniProtKB=Q9EWV2	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00018	EGF receptor signaling pathway	P00565	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	7492337	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00057	Wnt signaling pathway	P01444	Wnt	PANTR|Ensembl=ENSPTRG00000000313|UniProtKB=H2PY99	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00048	PI3 kinase pathway	P01205	NOS	RAT|RGD=3186|UniProtKB=Q62600	Nitric oxide synthase, endothelial	ISS	10435050	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P04393	Ras Pathway	P04552	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00006	Apoptosis signaling pathway	P00303	c-Jun	CHICK|Gene=JUN|UniProtKB=P18870	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00029	Huntington disease	P00775	Rac	MACMU|Ensembl=ENSMMUG00000022009|UniProtKB=F6RBZ7	Cell division control protein 42 homolog isoform 2	ISS			PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00036	Interleukin signaling pathway	P00979	MAPKAPK2	MACMU|Ensembl=ENSMMUG00000023567|UniProtKB=F7HHY8	Uncharacterized protein	ISS	8262198	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P05915	Opioid proenkephalin pathway	P05994	G-protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00184	Src	MOUSE|MGI=MGI=98397|UniProtKB=P05480	Neuronal proto-oncogene tyrosine-protein kinase Src	ISS	8054685	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P04393	Ras Pathway	P04547	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IDA	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P05913	Enkephalin release	P05977	G-Protein (s)	BRAFL|Gene=BRAFLDRAFT_220697|UniProtKB=C3ZSF0	Putative uncharacterized protein	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	TAKRU|Ensembl=ENSTRUG00000007253|UniProtKB=H2SZQ1	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	TAS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00034	Integrin signalling pathway	P00936	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MOUSE|MGI=MGI=1346868|UniProtKB=O09110	Dual specificity mitogen-activated protein kinase kinase 3	IC	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P06959	CCKR signaling map	P07153	RSK1/2	HUMAN|HGNC=10430|UniProtKB=Q15418	Ribosomal protein S6 kinase alpha-1	RCA	9124559	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05938	RhoA	XENTR|Xenbase=XB-GENE-941426|UniProtKB=Q28HZ4	Novel Rho protein	ISS	12039949	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	HUMAN|HGNC=667|UniProtKB=P61586	Transforming protein RhoA	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IDA	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04560	AP1	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00006	Apoptosis signaling pathway	P00310	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02756	N-acetylglucosamine metabolism	P03040	N-acetylneuraminate lyase	ECOLI|EcoGene=EG10637|UniProtKB=P0A6L4	N-acetylneuraminate lyase	ISS			PTHR42849:SF1	N-ACETYLNEURAMINATE LYASE
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00048	PI3 kinase pathway	P01199	Galpha	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	MACMU|Ensembl=ENSMMUG00000015891|UniProtKB=F7BVN4	Transcription factor IIB	ISS			PTHR12458:SF8	CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P04398	p53 pathway feedback loops 2	P04651	Ras	HUMAN|HGNC=6407|UniProtKB=P01116	GTPase KRas	IDA	6287573	PubMed	PTHR24070:SF186	GTPASE KRAS
P00049	Parkinson disease	P01219	SAPK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00036	Interleukin signaling pathway	P00985	PDK1/2	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	IDA	11256888	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	DROME|FlyBase=FBgn0011582|UniProtKB=P41596	Dopamine receptor 1	IDA			PTHR43893:SF6	DOPAMINE RECEPTOR 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02738	De novo purine biosynthesis	P02891	GDP kinase	BOVIN|Ensembl=ENSBTAG00000003025|UniProtKB=F1MCI2	Nucleoside diphosphate kinase	ISS			PTHR11349:SF70	NUCLEOSIDE DIPHOSPHATE KINASE 6
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	PSEAE|EnsemblGenome=PA4588|UniProtKB=Q9HVJ7	Glutamate dehydrogenase	ISS			PTHR43571:SF1	NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED
P00018	EGF receptor signaling pathway	P00543	ERK1-2	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	IGI	6319455	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00010	B cell activation	P00376	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CHICK|Ensembl=ENSGALG00000027629|UniProtKB=Q5ZJ03	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00056	VEGF signaling pathway	P01407	Erk	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00263	TRAIL	MOUSE|MGI=MGI=107414|UniProtKB=P50592	Tumor necrosis factor ligand superfamily member 10	IDA	8777713	PubMed	PTHR11471:SF27	TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 10
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	PANTR|Ensembl=ENSPTRG00000009472|UniProtKB=H2QZP7	Clathrin heavy chain	ISS	9388255	PubMed	PTHR10292:SF7	CLATHRIN HEAVY CHAIN 1
P02746	Heme biosynthesis	P02983	Hydroxymethylbilane synthase	STRCO|EnsemblGenome=CAB45352|UniProtKB=Q9WX16	Porphobilinogen deaminase 1	ISS			PTHR11557:SF0	PORPHOBILINOGEN DEAMINASE
P00049	Parkinson disease	P01227	20S proteasome	MOUSE|MGI=MGI=3649015|UniProtKB=D3YUM8	Proteasome subunit beta type	ISS	12859888	PubMed	PTHR11599:SF62	PROTEASOME SUBUNIT BETA TYPE-3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DANRE|ZFIN=ZDB-GENE-030131-172|UniProtKB=Q6IQR3	Actin, alpha, cardiac muscle 1a	IDA	10974003	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00049	Parkinson disease	P01227	20S proteasome	DANRE|ZFIN=ZDB-GENE-001208-2|UniProtKB=Q1LWY1	Proteasome subunit beta type	TAS	12859888	PubMed	PTHR11599:SF45	PROTEASOME SUBUNIT BETA TYPE
P00029	Huntington disease	P00765	Hip-1	MACMU|Ensembl=ENSMMUG00000005229|UniProtKB=F7C2D3	Uncharacterized protein	ISS	9147654	PubMed	PTHR10407:SF14	HUNTINGTIN-INTERACTING PROTEIN 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04455	beta-endorphin	HUMAN|HGNC=9201|UniProtKB=P01189	Pro-opiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MACMU|Ensembl=ENSMMUG00000003334|UniProtKB=F7EH57	Uncharacterized protein	ISS			PTHR13140:SF372	UNCONVENTIONAL MYOSIN-XVIIIB
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IC	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00024	Glycolysis	P00680	Phosphoglyceromutase	FUSNN|EnsemblGenome=FN0729|UniProtKB=Q8RFG9	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase	ISS	21886394	PubMed	PTHR11931:SF31	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00552	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00059	p53 pathway	P01486	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00193	SOS-1	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IDA	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00029	Huntington disease	P00800	PolyQ Htt	MOUSE|MGI=MGI=96067|UniProtKB=P42859	Huntingtin	TAS	9462744	PubMed	PTHR10170:SF10	HUNTINGTIN
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MONDO|Ensembl=ENSMODG00000003295|UniProtKB=F7EG01	Serine/threonine-protein kinase receptor	ISS	11252892	PubMed	PTHR23255:SF64	ACTIVIN RECEPTOR TYPE-2A
P02738	De novo purine biosynthesis	P02898	Phosphoribosylformylglycinamide  synthase	ARATH|TAIR=AT1G74260|UniProtKB=Q9M8D3	Probable phosphoribosylformylglycinamidine synthase, chloroplastic/mitochondrial	ISS			PTHR10099:SF1	PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DICPU|Gene=DICPUDRAFT_46519|UniProtKB=F0Z796	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00047	PDGF signaling pathway	P01154	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P00034	Integrin signalling pathway	P00920	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00021	FGF signaling pathway	P00644	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MOUSE|MGI=MGI=1336171|UniProtKB=Q9DAS9	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IDA	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00008	Axon guidance mediated by Slit/Robo	P00352	DCC	CANLF|Ensembl=ENSCAFG00000000157|UniProtKB=F1PAZ4	Uncharacterized protein	ISS	12810718	PubMed	PTHR44146:SF3	NETRIN RECEPTOR DCC
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04374	5HT2 type receptor mediated signaling pathway	P04413	K+ channel	BOVIN|Ensembl=ENSBTAG00000018193|UniProtKB=E1BHX8	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00006	Apoptosis signaling pathway	P00314	MKK3	CANLF|Ensembl=ENSCAFG00000018530|UniProtKB=F1PXD3	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P02740	De novo pyrimidine ribonucleotides biosythesis	P02927	Dihydrooratate oxidase	DEIRA|EnsemblGenome=DR_0501|UniProtKB=Q9RX14	Dihydroorotate dehydrogenase (quinone)	ISS			PTHR43517:SF1	DIHYDROOROTATE DEHYDROGENASE  QUINONE , MITOCHONDRIAL
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00011	Blood coagulation	P00458	GP IIIa	HUMAN|Ensembl=ENSG00000259753|UniProtKB=H3BM21	Integrin beta (Fragment)	ISS	4206165	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	IGI	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P04395	Vasopressin synthesis	P04594	Neurophysin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	XENTR|Xenbase=XB-GENE-1010483|UniProtKB=F7AF72	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P05918	p38 MAPK pathway	P06016	HSP27	CANLF|Gene=HSPB1|UniProtKB=P42929	Heat shock protein beta-1	ISS			PTHR11527:SF114	HEAT SHOCK PROTEIN BETA-1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	NEUCR|EnsemblGenome=EFNCRG00000004240|UniProtKB=Q01386	cAMP-dependent protein kinase regulatory subunit	ISS	97076137	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00269	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P02755	Methylmalonyl pathway	P03034	Methylmalonyl-CoA mutase	STRCO|Gene=CAB71846|UniProtKB=Q9L1X6	Probable isobutyryl-CoA mutase, small subunit	ISS			PTHR23408:SF19	SUBFAMILY NOT NAMED
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00001	Adrenaline and noradrenaline biosynthesis	P00061	PNMT	MOUSE|MGI=MGI=1099443|UniProtKB=O55239	Nicotinamide N-methyltransferase	ISS			PTHR10867:SF5	NICOTINAMIDE N-METHYLTRANSFERASE
P00005	Angiogenesis	P00223	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	7492337	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04413	K+ channel	RAT|RGD=61997|UniProtKB=O54912	Potassium channel subfamily K member 3	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	TAS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00029	Huntington disease	P00801	Fos protein	MACMU|Ensembl=ENSMMUG00000010574|UniProtKB=A5A6H2	C-fos	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	HUMAN|HGNC=1077|UniProtKB=O00238	Bone morphogenetic protein receptor type-1B	TAS	10683140	PubMed	PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	RAT|RGD=621876|UniProtKB=P97610	Synaptotagmin-12	RCA			PTHR10024:SF252	SYNAPTOTAGMIN-12
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	RAT|RGD=69319|UniProtKB=P54313	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00749	RGS9	CANLF|Ensembl=ENSCAFG00000011148|UniProtKB=J9P1Y8	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF170	REGULATOR OF G-PROTEIN SIGNALING 9
P00036	Interleukin signaling pathway	P00997	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	95096035	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	RAT|RGD=620683|UniProtKB=P67999	Ribosomal protein S6 kinase beta-1	ISS	11861821	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00054	Toll receptor signaling pathway	P01375	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00004	Alzheimer disease-presenilin pathway	P00168	E-cadherin intracellular fragment	MACMU|Ensembl=ENSMMUG00000010393|UniProtKB=F7D992	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P00057	Wnt signaling pathway	P01457	GBeta	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IDA	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00006	Apoptosis signaling pathway	P00259	TNF	HUMAN|HGNC=11892|UniProtKB=P01375	Tumor necrosis factor	ISS	11911478	PubMed	PTHR11471:SF23	TUMOR NECROSIS FACTOR
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_127488|UniProtKB=C3XYC7	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	11956331	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05913	Enkephalin release	P05974	G-Protein (i)	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	IDA	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01181	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02749	Leucine biosynthesis	P03000	Branched chain amino acid aminotransferase	DROME|FlyBase=FBgn0030482|UniProtKB=Q9VYD5	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF44	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P00034	Integrin signalling pathway	P00936	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	IPI	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P00057	Wnt signaling pathway	P01435	SWI/SNF	MACMU|Ensembl=ENSMMUG00000005526|UniProtKB=F7GFC4	Uncharacterized protein	ISS	11532957	PubMed	PTHR10799:SF870	HELICASE-LIKE TRANSCRIPTION FACTOR
P00057	Wnt signaling pathway	P01447	Dishevelled	BOVIN|Ensembl=ENSBTAG00000003075|UniProtKB=E1BK34	Uncharacterized protein	ISS	11212302	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P02748	Isoleucine biosynthesis	P02997	Acetolactate synthase	MACMU|Ensembl=ENSMMUG00000007729|UniProtKB=F7C8Z1	Acetolactate synthase-like protein	ISS			PTHR18968:SF155	ACETOLACTATE SYNTHASE-LIKE PROTEIN
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MONDO|Ensembl=ENSMODG00000023429|UniProtKB=F6XI83	Uncharacterized protein	ISS	1608964	PubMed	PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	CANLF|Ensembl=ENSCAFG00000002067|UniProtKB=F1PUW7	Uncharacterized protein	ISS	94365697	PubMed	PTHR11958:SF69	EXCITATORY AMINO ACID TRANSPORTER 3
P00049	Parkinson disease	P01211	ERK	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	IDA	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	CANLF|Ensembl=ENSCAFG00000006453|UniProtKB=F6X958	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IDA	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00018	EGF receptor signaling pathway	P00552	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	P01471	alpha-catenin	XENTR|Xenbase=XB-GENE-479599|UniProtKB=F7DHT4	Uncharacterized protein	ISS	9362521	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	XENTR|Xenbase=XB-GENE-868100|UniProtKB=F6W7G5	Uncharacterized protein	ISS	9783586	PubMed	PTHR10814:SF23	TRANSDUCIN-LIKE ENHANCER PROTEIN 1
P00005	Angiogenesis	P00193	SOS-1	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02723	Adenine and hypoxanthine salvage pathway	P02809	Xanthine dehydrogenase	CAEEL|WormBase=WBGene00010083|UniProtKB=O17892	Uncharacterized protein	ISS			PTHR11908:SF100	XANTHINE DEHYDROGENASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00034	Integrin signalling pathway	P00920	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00004	Alzheimer disease-presenilin pathway	P00164	Nectin 1alpha N-terminal fragment	CANLF|Ensembl=ENSCAFG00000012012|UniProtKB=F1PCB6	Uncharacterized protein	ISS	12376527	PubMed	PTHR23277:SF69	NECTIN-1
P00049	Parkinson disease	P01219	SAPK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IDA	94179345	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00057	Wnt signaling pathway	P01428	Frizzled	MONDO|Ensembl=ENSMODG00000006737|UniProtKB=F7CDC6	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF90	FRIZZLED-8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00048	PI3 kinase pathway	P01177	P110ACT	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	PHYPA|Gene=PHYPADRAFT_210000|UniProtKB=A9S9L5	Predicted protein	ISS	3885394	PubMed	PTHR23050:SF245	AT16150P-RELATED
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	METAC|EnsemblGenome=MA_1524|UniProtKB=Q8TQL6	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00018	EGF receptor signaling pathway	P00545	JNK1-3	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00010	B cell activation	P00398	IP3R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00005	Angiogenesis	P00204	PLD	PANTR|Ensembl=ENSPTRG00000015626|UniProtKB=H2R1L6	Phospholipase D1, phosphatidylcholine-specific	ISS	15668389	PubMed	PTHR18896:SF57	PHOSPHOLIPASE D1
P00036	Interleukin signaling pathway	P00987	SRF	BOVIN|Ensembl=ENSBTAG00000012777|UniProtKB=E1BJP4	Uncharacterized protein	ISS	8660892	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04658	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00036	Interleukin signaling pathway	P00964	p90RSK	HUMAN|HGNC=10431|UniProtKB=Q15349	Ribosomal protein S6 kinase alpha-2	IC	15526037	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00051	TCA cycle	P01267	Citrate Synthase	XENTR|Xenbase=XB-GENE-943160|UniProtKB=Q28DK1	Citrate synthase, mitochondrial	ISS	12477932	PubMed	PTHR11739:SF8	CITRATE SYNTHASE, MITOCHONDRIAL
P02736	Coenzyme A biosynthesis	P02885	Pantothenate kinase	PANTR|Ensembl=ENSPTRG00000000052|UniProtKB=H2PXV0	Pantothenate kinase 4	ISS			PTHR12280:SF20	PANTOTHENATE KINASE 4
P00004	Alzheimer disease-presenilin pathway	P00114	actin	HUMAN|HGNC=145|UniProtKB=P63267	Actin, gamma-enteric smooth muscle	IDA	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00006	Apoptosis signaling pathway	P00321	HSP70	HUMAN|HGNC=5234|UniProtKB=P34931	Heat shock 70 kDa protein 1-like	ISS	12150907	PubMed	PTHR19375:SF210	HEAT SHOCK 70 KDA PROTEIN 1-LIKE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	DROME|FlyBase=FBgn0024941|UniProtKB=Q9VXA3	LP21163p	IDA	8756726	PubMed	PTHR10845:SF151	LP21163P
P00019	Endothelin signaling pathway	P00566	ERK	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	NAS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00053	T cell activation	P01336	Jnk	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00035	Interferon-gamma signaling pathway	P00960	PTP	MACMU|Ensembl=ENSMMUG00000013253|UniProtKB=F6ZJD8	Tyrosine-protein phosphatase non-receptor type	ISS	95163101	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00057	Wnt signaling pathway	P01447	Dishevelled	DANRE|ZFIN=ZDB-GENE-010319-1|UniProtKB=B8JMI2	Uncharacterized protein	ISS	11212302	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P00045	Notch signaling pathway	P01118	Numb	CHICK|Ensembl=ENSGALG00000009300|UniProtKB=F1P3F5	Uncharacterized protein	IPI	10402194	PubMed	PTHR11232:SF33	PROTEIN NUMB HOMOLOG
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT4G01370|UniProtKB=Q39024	Mitogen-activated protein kinase 4	IDA	2191146	gi	PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P00037	Ionotropic glutamate receptor pathway	P00999	PSD95	RAT|RGD=69264|UniProtKB=Q9JLU4	SH3 and multiple ankyrin repeat domains protein 3	ISS	20020275	PubMed	PTHR24135:SF4	SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN 3
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	CHICK|Gene=PSEN2|UniProtKB=Q90X07	Presenilin-2	TAS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00054	Toll receptor signaling pathway	P01375	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P06664	Gonadotropin-releasing hormone receptor pathway	P06740	BMPR-IA/IB/II	MOUSE|MGI=MGI=107191|UniProtKB=P36898	Bone morphogenetic protein receptor type-1B	RCA	9395284	PubMed	PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P00019	Endothelin signaling pathway	P00584	Gs	MACMU|Ensembl=ENSMMUG00000010266|UniProtKB=F6PV18	Uncharacterized protein	ISS	14500986	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00034	Integrin signalling pathway	P00948	Rho	DAPPU|EnsemblGenome=DAPPUDRAFT_301996|UniProtKB=E9HL06	Putative uncharacterized protein	ISS	7798239	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P05913	Enkephalin release	P05972	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	11035810	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DICPU|Gene=DICPUDRAFT_48914|UniProtKB=F0ZK40	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF154	ACTIN-17-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	HUMAN|HGNC=9997|UniProtKB=O15492	Regulator of G-protein signaling 16	IDA	8756726	PubMed	PTHR10845:SF187	REGULATOR OF G-PROTEIN SIGNALING 16
P00019	Endothelin signaling pathway	P00586	Gq	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00547	PP2A	MONDO|Ensembl=ENSMODG00000019007|UniProtKB=F7C5Z9	Uncharacterized protein	ISS	96161994	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00046	Oxidative stress response	P01129	JNK1/2	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00012	Cadherin signaling pathway	P00475	Frizzled	MACMU|Ensembl=ENSMMUG00000013656|UniProtKB=F7GI70	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF126	FRIZZLED-5
P00029	Huntington disease	P00801	Fos protein	BOVIN|Ensembl=ENSBTAG00000004322|UniProtKB=O77628	Proto-oncogene c-Fos	TAS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	PANTR|Ensembl=ENSPTRG00000005528|UniProtKB=H2Q705	Nucleoside diphosphate kinase	ISS			PTHR11349:SF68	NUCLEOSIDE DIPHOSPHATE KINASE-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PANTR|Ensembl=ENSPTRG00000002086|UniProtKB=H2Q1A9	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IGI	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00017	DNA replication	P00530	Top	MOUSE|MGI=MGI=98790|UniProtKB=Q01320	DNA topoisomerase 2-alpha	RCA			PTHR10169:SF46	DNA TOPOISOMERASE 2-ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CHICK|Ensembl=ENSGALG00000006576|UniProtKB=E1BUE5	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04393	Ras Pathway	P04546	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	IDA	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MOUSE|MGI=MGI=1336171|UniProtKB=Q9DAS9	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	TAKRU|Ensembl=ENSTRUG00000006307|UniProtKB=H2SSM1	Uncharacterized protein	ISS			PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00012	Cadherin signaling pathway	P00464	Fyn	TAKRU|Ensembl=ENSTRUG00000014739|UniProtKB=H2UL58	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00029	Huntington disease	P00778	NMDA receptor	PANTR|Ensembl=ENSPTRG00000023608|UniProtKB=H2QZZ2	Uncharacterized protein	ISS	11554554	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CAEEL|WormBase=WBGene00001187|UniProtKB=Q8MQA1	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00053	T cell activation	P01336	Jnk	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IC	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	PANTR|Ensembl=ENSPTRG00000012508|UniProtKB=H2QIS5	Uncharacterized protein	ISS	11907044	PubMed	PTHR44025:SF7	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	11832947	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00019	Endothelin signaling pathway	P00590	IP3 R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04398	p53 pathway feedback loops 2	P04661	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01142	p90RSK	MOUSE|MGI=MGI=104557|UniProtKB=P18654	Ribosomal protein S6 kinase alpha-3	ISS	6755374	gi	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00029	Huntington disease	P00810	GAPDH	CAEEL|WormBase=WBGene00001684|UniProtKB=P17329	Glyceraldehyde-3-phosphate dehydrogenase 2	IPI			PTHR10836:SF52	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED
P00006	Apoptosis signaling pathway	P00274	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00642	MEK1-2	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02723	Adenine and hypoxanthine salvage pathway	P02807	Deoxyadenosine deaminase	RAT|RGD=2031|UniProtKB=Q920P6	Adenosine deaminase	ISS			PTHR11409:SF43	ADENOSINE DEAMINASE
P00053	T cell activation	P01314	nck	CANLF|Ensembl=ENSCAFG00000007451|UniProtKB=E2RHV6	Uncharacterized protein	ISS	12874226	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00006	Apoptosis signaling pathway	P00302	ATF	MOUSE|MGI=MGI=109349|UniProtKB=P16951	Cyclic AMP-dependent transcription factor ATF-2	ISS	10664585	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00036	Interleukin signaling pathway	P00970	Interleukin	RAT|RGD=2888|UniProtKB=Q61453	Interleukin-17A	IC			PTHR44866:SF1	INTERLEUKIN-17A
P00029	Huntington disease	P00790	beta-Tubulin	ORYSJ|EnsemblGenome=OS06G0671900|UniProtKB=Q40665	Tubulin beta-3 chain	TAS	9454836	PubMed	PTHR11588:SF245	TUBULIN BETA-4 CHAIN-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	ISS	15313841	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P05730	Endogenous cannabinoid signaling	P05751	Galpha	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00029	Huntington disease	P00780	Microtubule	HUMAN|HGNC=20778|UniProtKB=P07437	Tubulin beta chain	IDA	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01162	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00053	T cell activation	P01314	nck	MONDO|Ensembl=ENSMODG00000002546|UniProtKB=F7ALW1	Uncharacterized protein	ISS	12874226	PubMed	PTHR44108:SF1	CYTOPLASMIC PROTEIN NCK2
P00029	Huntington disease	P00780	Microtubule	YEAST|SGD=S000001857|UniProtKB=P02557	Tubulin beta chain	IDA	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00048	PI3 kinase pathway	P01199	Galpha	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IC	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00059	p53 pathway	G04699	BAI-1	MONDO|Ensembl=ENSMODG00000018608|UniProtKB=F7BPS2	Uncharacterized protein	ISS			PTHR12011:SF40	ADHESION G PROTEIN-COUPLED RECEPTOR B3
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=4401|UniProtKB=O14775	Guanine nucleotide-binding protein subunit beta-5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00029	Huntington disease	P00797	p53	PANTR|Ensembl=ENSPTRG00000006818|UniProtKB=H2Q913	Cytoplasmic FMR1 interacting protein 1	ISS			PTHR12195:SF2	CYTOPLASMIC FMR1-INTERACTING PROTEIN 1
P00018	EGF receptor signaling pathway	P00558	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00056	VEGF signaling pathway	P01414	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00023	General transcription regulation	P00658	TBP-associated factors	HUMAN|HGNC=11542|UniProtKB=Q16594	Transcription initiation factor TFIID subunit 9	ISS			PTHR12595:SF8	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	HUMAN|HGNC=143|UniProtKB=P68032	Actin, alpha cardiac muscle 1	IC	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00009	Axon guidance mediated by netrin	P00359	NFAT	PANTR|Ensembl=ENSPTRG00000008260|UniProtKB=H2QBD7	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	ISS	12015605	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00010	B cell activation	P00402	Jnk	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	ANOGA|EnsemblGenome=AGAP010750|UniProtKB=Q7PMK5	AGAP010750-PA	ISS	8930069	PubMed	PTHR13715:SF79	RYANODINE RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00036	Interleukin signaling pathway	P00995	c-Myc	HUMAN|HGNC=7553|UniProtKB=P01106	Myc proto-oncogene protein	ISS	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	IDA	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	TAS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ANOGA|EnsemblGenome=AGAP005913|UniProtKB=Q7Q6D2	AGAP005913-PA	IC	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00019	Endothelin signaling pathway	P00591	PLCbeta	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00053	T cell activation	P01330	IKK	MOUSE|MGI=MGI=1338071|UniProtKB=O88351	Inhibitor of nuclear factor kappa-B kinase subunit beta	IGI	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DANRE|ZFIN=ZDB-GENE-000329-1|UniProtKB=Q7ZVI7	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	DANRE|ZFIN=ZDB-GENE-030131-8013|UniProtKB=F1QBT6	Uncharacterized protein	ISS	12497607	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MACMU|Ensembl=ENSMMUG00000005441|UniProtKB=F7GQ00	Uncharacterized protein	ISS	11451570	PubMed	PTHR11848:SF29	INHIBIN BETA B CHAIN
P00059	p53 pathway	P01486	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05976	Enkephalin	XENTR|Xenbase=XB-GENE-942760|UniProtKB=F6Y5F6	Uncharacterized protein	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00005	Angiogenesis	P00181	SHP2	CANLF|Ensembl=ENSCAFG00000008894|UniProtKB=F1Q3J6	Tyrosine-protein phosphatase non-receptor type	ISS	14525967	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00049	Parkinson disease	P01227	20S proteasome	CAEEL|WormBase=WBGene00003925|UniProtKB=Q95005	Proteasome subunit alpha type-7	TAS	12859888	PubMed	PTHR11599:SF15	PROTEASOME SUBUNIT ALPHA TYPE
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	ANOGA|EnsemblGenome=AGAP002647|UniProtKB=Q7QCI6	AGAP002647-PA	IDA			PTHR44087:SF2	PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, LIVER/TESTIS ISOFORM
P00047	PDGF signaling pathway	P01175	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00024	Glycolysis	P00671	Phosphoglycerate kinase	MACMU|Ensembl=ENSMMUG00000012874|UniProtKB=F6UJ08	Phosphoglycerate kinase	ISS	79199779	PubMed	PTHR11406:SF14	PHOSPHOGLYCERATE KINASE 1
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00796	Kainate receptor	MACMU|Ensembl=ENSMMUG00000004886|UniProtKB=F7AGT9	Uncharacterized protein	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00019	Endothelin signaling pathway	P00590	IP3 R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00029	Huntington disease	P00796	Kainate receptor	CHICK|Ensembl=ENSGALG00000015835|UniProtKB=F1NZT2	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00057	Wnt signaling pathway	P01435	SWI/SNF	BOVIN|Gene=SMARCD1|UniProtKB=Q2TBN1	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1	ISS	11532957	PubMed	PTHR13844:SF1	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D MEMBER 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	IDA	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P05734	Synaptic vesicle trafficking	P05773	Munc13	HUMAN|HGNC=12566|UniProtKB=O14795	Protein unc-13 homolog B	TAS	605836	OMIM	PTHR10480:SF8	PROTEIN UNC-13 HOMOLOG B
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05913	Enkephalin release	P05977	G-Protein (s)	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00053	T cell activation	P01312	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	IC	10553940	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00049	Parkinson disease	P01212	p38 MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00005	Angiogenesis	P00221	JNK1	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00060	Ubiquitin proteasome pathway	P01491	E2	PANTR|Ensembl=ENSPTRG00000001850|UniProtKB=H2Q0X0	Ubiquitin-conjugating enzyme E2T (Putative)	ISS			PTHR44511:SF1	UBIQUITIN-CONJUGATING ENZYME E2 T
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00019	Endothelin signaling pathway	P00572	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MOUSE|MGI=MGI=87906|UniProtKB=P63260	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00036	Interleukin signaling pathway	P00976	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS			PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000009939|UniProtKB=H2QED9	Cadherin 2, type 1, N-cadherin (Neuronal)	ISS	13678586	PubMed	PTHR24027:SF79	CADHERIN-2
P05915	Opioid proenkephalin pathway	P05994	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00059	p53 pathway	P04609	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00021	FGF signaling pathway	P00636	FGFR1-4	CANLF|Ensembl=ENSCAFG00000016518|UniProtKB=F6XBX5	Fibroblast growth factor receptor	ISS	11549253	PubMed	PTHR24416:SF343	FIBROBLAST GROWTH FACTOR RECEPTOR 4
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	TAS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00030	Hypoxia response via HIF activation	P00825	Thioredoxin	EMENI|EnsemblGenome=CADANIAG00002566|UniProtKB=P29429	Thioredoxin	ISS			PTHR10438:SF360	THIOREDOXIN H9-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01428	Frizzled	DANRE|ZFIN=ZDB-GENE-990415-224|UniProtKB=F1QBI2	Uncharacterized protein	IDA	11212302	PubMed	PTHR11309:SF34	FRIZZLED-2
P00019	Endothelin signaling pathway	P00586	Gq	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00590	IP3 R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00046	Oxidative stress response	P01135	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	TAS	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00624	14-3-3	TAKRU|Ensembl=ENSTRUG00000004697|UniProtKB=H2SFG7	Uncharacterized protein	ISS	9507245	gi	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00012	Cadherin signaling pathway	P00474	Wnt	PANTR|Ensembl=ENSPTRG00000004519|UniProtKB=H2Q569	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00053	T cell activation	P01294	NFAT	MOUSE|MGI=MGI=103296|UniProtKB=P97305	Nuclear factor of activated T-cells, cytoplasmic 3	IGI	12787506	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00005	Angiogenesis	P00206	Wnt	XENTR|Xenbase=XB-GENE-960148|UniProtKB=F6XMD3	Protein Wnt (Fragment)	ISS	11266476	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00018	EGF receptor signaling pathway	P00547	PP2A	HUMAN|HGNC=9300|UniProtKB=P62714	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	IGI	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS			PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00054	Toll receptor signaling pathway	P01369	MKK1	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00034	Integrin signalling pathway	P00916	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IPI	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT1G59580|UniProtKB=Q39022	Mitogen-activated protein kinase 2	ISS	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00005	Angiogenesis	P00214	HIF-1	CHICK|Gene=HIF1A|UniProtKB=Q9YIB9	Hypoxia-inducible factor 1-alpha	ISS			PTHR23043:SF7	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA
P00052	TGF-beta signaling pathway	P01292	RSmads	MACMU|Ensembl=ENSMMUG00000007816|UniProtKB=F7CP27	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF42	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00899	IRS 1-4	DROME|FlyBase=FBgn0024248|UniProtKB=Q9XTN2	Insulin receptor substrate 1	ISS	15175753	PubMed	PTHR10614:SF13	INSULIN RECEPTOR SUBSTRATE 1
P00029	Huntington disease	P00805	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00545	JNK1-3	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	MACMU|Ensembl=ENSMMUG00000022009|UniProtKB=F6RBZ7	Cell division control protein 42 homolog isoform 2	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IGI	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00036	Interleukin signaling pathway	P00972	MNK1/2	HUMAN|HGNC=7110|UniProtKB=Q9BUB5	MAP kinase-interacting serine/threonine-protein kinase 1	IC	9155018	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	RAT|RGD=1304749|UniProtKB=A0A0G2K0H3	Protein Lrp6	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IDA	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00048	PI3 kinase pathway	P01189	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00056	VEGF signaling pathway	P01411	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	ORYSJ|EnsemblGenome=OS06G0548000|UniProtKB=Q0DBN4	Aspartate aminotransferase	ISS			PTHR11879:SF10	ASPARTATE AMINOTRANSFERASE
P00006	Apoptosis signaling pathway	P00260	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	DROME|FlyBase=FBgn0019985|UniProtKB=P91685	Metabotropic glutamate receptor	IDA	12351712	PubMed	PTHR24060:SF137	METABOTROPIC GLUTAMATE RECEPTOR
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	TAKRU|Ensembl=ENSTRUG00000009259|UniProtKB=H2TF39	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00029	Huntington disease	P00796	Kainate receptor	BOVIN|Ensembl=ENSBTAG00000009269|UniProtKB=F1MCM2	Uncharacterized protein	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00045	Notch signaling pathway	G01541	E(spl)-C genes	DROME|FlyBase=FBgn0002733|UniProtKB=Q01069	Enhancer of split mbeta protein	TAS	14973298	PubMed	PTHR10985:SF12	ENHANCER OF SPLIT M3 PROTEIN-RELATED
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00591	PLCbeta	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04398	p53 pathway feedback loops 2	P04665	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00050	Plasminogen activating cascade	P01245	PAI-1	BOVIN|Ensembl=ENSBTAG00000014465|UniProtKB=P13909	Plasminogen activator inhibitor 1	IDA	10692390	PubMed	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00034	Integrin signalling pathway	P00925	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00047	PDGF signaling pathway	P01142	p90RSK	BOVIN|Gene=RPS6KB1|UniProtKB=Q6TJY3	Ribosomal protein S6 kinase beta-1	ISS	15116068	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	SCHPO|PomBase=SPBC32H8.12c|UniProtKB=P10989	Actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	CANLF|Ensembl=ENSCAFG00000012565|UniProtKB=F1PRW0	Uncharacterized protein	ISS	11827521	PubMed	PTHR10223:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	MACMU|Ensembl=ENSMMUG00000030199|UniProtKB=F7HPQ9	Uncharacterized protein	ISS			PTHR13218:SF15	TAF11-LIKE PROTEIN ENSP00000332601-RELATED
P00005	Angiogenesis	P00238	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00054	Toll receptor signaling pathway	P01341	Elk1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	ISS	9644975	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00049	Parkinson disease	P01238	14-3-3	ORYSJ|EnsemblGenome=OS02G0580300|UniProtKB=Q6EUP4	14-3-3-like protein GF14-E	ISS	10407019	PubMed	PTHR18860:SF36	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00282	IGFR2	MACMU|Ensembl=ENSMMUG00000015658|UniProtKB=F7AJI7	Uncharacterized protein	ISS	11081635	PubMed	PTHR15071:SF17	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00006	Apoptosis signaling pathway	P00273	p53	DANRE|ZFIN=ZDB-GENE-990415-270|UniProtKB=P79734	Cellular tumor antigen p53	ISS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P02731	Biotin biosynthesis	P02858	8-Amino-7-oxononanoate synthase	GLOVI|EnsemblGenome=BAC88338|UniProtKB=Q7NNL4	Putative 8-amino-7-oxononanoate synthase	ISS			PTHR13693:SF77	8-AMINO-7-OXONONANOATE SYNTHASE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	RCA	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00017	DNA replication	P00527	Histones	STRPU|EnsemblGenome=SPU_008993|UniProtKB=W4XZX1	Histone H3	ISS	12413958	PubMed	PTHR11426:SF20	HISTONE H3-LIKE CENTROMERIC PROTEIN A
P00006	Apoptosis signaling pathway	P00269	MAPK	ORYSJ|EnsemblGenome=OS03G0285800|UniProtKB=Q10N20	Mitogen-activated protein kinase 5	ISS	11707292	PubMed	PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	MOUSE|MGI=MGI=95814|UniProtKB=Q60934	Glutamate receptor ionotropic, kainate 1	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	DANRE|ZFIN=ZDB-GENE-060824-1|UniProtKB=C3PTE8	Beta-arrestin 1	ISS	9388255	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00059	p53 pathway	P04635	Sumo-1 ligase	MONDO|Ensembl=ENSMODG00000016299|UniProtKB=F7ATG0	Small ubiquitin-related modifier	ISS			PTHR10562:SF52	SMALL UBIQUITIN-RELATED MODIFIER 1
P00029	Huntington disease	P00780	Microtubule	CHICK|Ensembl=ENSGALG00000007447|UniProtKB=P09207	Tubulin beta-6 chain	IDA	12932731	PubMed	PTHR11588:SF112	TUBULIN BETA-1 CHAIN
P00059	p53 pathway	P01486	Akt	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	TAS	14526383	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04397	p53 pathway by glucose deprivation	P04641	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	8170357	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00045	Notch signaling pathway	P01107	Fringe	PANTR|Ensembl=ENSPTRG00000018864|UniProtKB=H2QU37	Uncharacterized protein	ISS	12670869	PubMed	PTHR10811:SF7	BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE LUNATIC FRINGE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	ARATH|TAIR=AT1G79000|UniProtKB=Q9C5X9	Histone acetyltransferase HAC1	IDA			PTHR13808:SF1	NEJIRE, ISOFORM C
P00013	Cell cycle	P00480	Proteasome	CHICK|Ensembl=ENSGALG00000003700|UniProtKB=F1NPQ0	Uncharacterized protein	ISS	9426256	PubMed	PTHR10855:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12
P00054	Toll receptor signaling pathway	P01375	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	IDA	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02928	Dihydroorotase	SYNY3|EnsemblGenome=BAA16951|UniProtKB=P72934	Probable dihydroorotase-like protein	ISS			PTHR43668:SF1	SUBFAMILY NOT NAMED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000024633|UniProtKB=F1MBU9	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P02742	Tetrahydrofolate biosynthesis	P02945	Dihydropteroate synthase	FUSNN|EnsemblGenome=FN0073|UniProtKB=Q8RH41	Dihydropteroate synthase	ISS			PTHR20941:SF1	FOLIC ACID SYNTHESIS PROTEIN FOL1
P05913	Enkephalin release	P05977	G-Protein (s)	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00019	Endothelin signaling pathway	P00589	Akt	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	ISS	21291563	gi	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01208	Hsp70	CHICK|Ensembl=ENSGALG00000001000|UniProtKB=Q90593	78 kDa glucose-regulated protein	IDA	10934466	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P06664	Gonadotropin-releasing hormone receptor pathway	P06841	gnaq/11	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	RCA	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00005	Angiogenesis	P00219	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00012	Cadherin signaling pathway	P00463	betacatenin	MOUSE|MGI=MGI=88276|UniProtKB=Q02248	Catenin beta-1	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CHICK|Ensembl=ENSGALG00000011809|UniProtKB=F1NMB0	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P05918	p38 MAPK pathway	P06030	IL-1R	HUMAN|HGNC=5993|UniProtKB=P14778	Interleukin-1 receptor type 1	RCA			PTHR11890:SF26	INTERLEUKIN-1 RECEPTOR TYPE 1
P00037	Ionotropic glutamate receptor pathway	P01026	KA	PANTR|Gene=GRIK4|UniProtKB=Q5IS46	Glutamate receptor ionotropic, kainate 4	ISS	12778120	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	DROME|FlyBase=FBgn0010223|UniProtKB=Q05337	Guanine nucleotide-binding protein G(f) subunit alpha	IC			PTHR10218:SF229	GUANINE NUCLEOTIDE-BINDING PROTEIN G F  SUBUNIT ALPHA
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	HUMAN|HGNC=412|UniProtKB=P49189	4-trimethylaminobutyraldehyde dehydrogenase	IC			PTHR11699:SF228	4-TRIMETHYLAMINOBUTYRALDEHYDE DEHYDROGENASE
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IDA	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	CAEEL|WormBase=WBGene00002173|UniProtKB=Q9Y0A1	Inositol 1,4,5-trisphosphate receptor itr-1	IDA	11007872	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00057	Wnt signaling pathway	P01435	SWI/SNF	RAT|RGD=1308761|UniProtKB=Q4KLI0	Protein LOC103694876	ISS	11532957	PubMed	PTHR10019:SF5	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY B MEMBER 1
P00018	EGF receptor signaling pathway	P00547	PP2A	MOUSE|MGI=MGI=1321161|UniProtKB=P62715	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00321	HSP70	TRYB2|Gene=Tb11.01.3110|UniProtKB=Q383E5	Heat shock protein 70	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04552	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00796	Kainate receptor	MACMU|Ensembl=ENSMMUG00000022347|UniProtKB=F6ZCH5	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00005	Angiogenesis	P00227	PLA2	MACMU|Ensembl=ENSMMUG00000021423|UniProtKB=F7EEZ1	Phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	RAT|RGD=2743|UniProtKB=P31421	Metabotropic glutamate receptor 2	ISS	9407094	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00025	Hedgehog signaling pathway	P00682	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05731	GABA-B receptor II signaling	P05755	Gbeta	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	MOUSE|MGI=MGI=1339984|UniProtKB=Q8CIN4	Serine/threonine-protein kinase PAK 2	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00049	Parkinson disease	P01239	Cul-1	MACMU|Ensembl=ENSMMUG00000017541|UniProtKB=F6UKV3	Uncharacterized protein	ISS	12628165	PubMed	PTHR11932:SF81	CULLIN-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04542	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00376	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00010	B cell activation	P00384	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02731	Biotin biosynthesis	P02856	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	ECOLI|EcoGene=EG10117|UniProtKB=P12995	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	ISS			PTHR42684:SF3	ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE
P00029	Huntington disease	P00778	NMDA receptor	RAT|RGD=2736|UniProtKB=P35439	Glutamate receptor ionotropic, NMDA 1	IDA	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04393	Ras Pathway	P04558	p38	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	IDA	20451058	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	IC	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00005	Angiogenesis	P00238	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IDA	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	BOVIN|Gene=ARRB2|UniProtKB=P32120	Beta-arrestin-2	ISS	9388255	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DANRE|ZFIN=ZDB-GENE-050417-267|UniProtKB=F1QUN8	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF263	ACTIN
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	MACMU|Ensembl=ENSMMUG00000020218|UniProtKB=F6V935	Uncharacterized protein	ISS			PTHR23359:SF79	ADENYLATE KINASE ISOENZYME 5
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=1766|UniProtKB=Q9ULB5	Cadherin-7	IDA	8120095	PubMed	PTHR24027:SF91	CADHERIN-7
P00005	Angiogenesis	P00203	Erk	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00640	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DANRE|ZFIN=ZDB-GENE-040426-1489|UniProtKB=Q6PHV0	Syntaxin 3A	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00057	Wnt signaling pathway	P01465	Ggamma	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	HUMAN|HGNC=1957|UniProtKB=P32297	Neuronal acetylcholine receptor subunit alpha-3	ISS	12098588	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000018372|UniProtKB=F7H1J2	Uncharacterized protein	ISS	11259498	PubMed	PTHR24229:SF1	KAPPA-TYPE OPIOID RECEPTOR
P02738	De novo purine biosynthesis	P02901	Adenosuccinate lyase	PLAF7|EnsemblGenome=PFB0295w|UniProtKB=Q7KWJ4	Adenylosuccinate lyase	ISS			PTHR43411:SF1	ADENYLOSUCCINATE LYASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	97449291	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00060	Ubiquitin proteasome pathway	P01492	E1	PANTR|Ensembl=ENSPTRG00000015095|UniProtKB=H2R294	Ubiquitin-like modifier activating enzyme 3	ISS			PTHR10953:SF6	NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00514	MLCK	MACMU|Ensembl=ENSMMUG00000019786|UniProtKB=F7G5G3	Uncharacterized protein	ISS	600922	OMIM	PTHR45411:SF1	MYOSIN LIGHT CHAIN KINASE 3
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00006	Apoptosis signaling pathway	P00297	NFkappaB	BOVIN|Ensembl=ENSBTAG00000006017|UniProtKB=F6Q9X9	Uncharacterized protein	ISS	9133421	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P05916	Opioid prodynorphin pathway	P06002	G-protein	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02926	Aspartate carbamoyltransferase	PLAF7|EnsemblGenome=MAL13P1.221|UniProtKB=Q8IDP8	Aspartate carbamoyltransferase	ISS			PTHR11405:SF16	ASPARTATE CARBAMOYLTRANSFERASE, CHLOROPLASTIC
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00052	TGF-beta signaling pathway	P01284	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	RAT|RGD=3568|UniProtKB=P49800	Regulator of G-protein signaling 5	IDA	8756726	PubMed	PTHR10845:SF42	REGULATOR OF G-PROTEIN SIGNALING 5
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	MOUSE|MGI=MGI=107421|UniProtKB=Q61139	Proprotein convertase subtilisin/kexin type 7	IDA			PTHR42884:SF12	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 7
P00049	Parkinson disease	P01211	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	RAT|RGD=2846|UniProtKB=P28564	5-hydroxytryptamine receptor 1B	ISS	11701344	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P04397	p53 pathway by glucose deprivation	P04641	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	CAEEL|WormBase=WBGene00003844|UniProtKB=P41931	Ornithine decarboxylase	ISS			PTHR11482:SF6	ORNITHINE DECARBOXYLASE 1-RELATED
P00052	TGF-beta signaling pathway	P01275	P38	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	TAS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02741	Flavin biosynthesis	P02934	Riboflavin kinase	MACMU|Ensembl=ENSMMUG00000014829|UniProtKB=F6VQM7	Uncharacterized protein	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P00029	Huntington disease	P00796	Kainate receptor	PANTR|Ensembl=ENSPTRG00000011042|UniProtKB=H2QGF5	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	PANTR|Ensembl=ENSPTRG00000003699|UniProtKB=H2Q3R5	Syntaxin 3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00029	Huntington disease	P00775	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	TAS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00049	Parkinson disease	P01219	SAPK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P02765	Phenylalanine biosynthesis	P03100	Chorismate mutase	BACSU|EnsemblGenome=BSU22690|UniProtKB=P19080	Chorismate mutase AroH	ISS			PTHR21164:SF0	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000022548|UniProtKB=F6Y9J9	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P02747	Histidine biosynthesis	P02989	Phosphoribosyl AMP cyclohydrolase	ECOLI|EcoGene=EG10451|UniProtKB=P06989	Histidine biosynthesis bifunctional protein HisIE	ISS			PTHR42945:SF1	HISTIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN HISIE, CHLOROPLASTIC
P00021	FGF signaling pathway	P00627	ERK1-2	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	MOUSE|MGI=MGI=107426|UniProtKB=Q64385	Interleukin-11 receptor subunit alpha-1	IEP	8973540	PubMed	PTHR23036:SF29	INTERLEUKIN-11 RECEPTOR SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	DROME|FlyBase=FBgn0266137|UniProtKB=Q24563	Dopamine receptor 2	IDA	11248120	PubMed	PTHR24248:SF56	DOPAMINE RECEPTOR 2
P00056	VEGF signaling pathway	P01407	Erk	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02756	N-acetylglucosamine metabolism	P03041	Glucosamine-6-phosphate deaminase	MONDO|Ensembl=ENSMODG00000025078|UniProtKB=F6R5T8	Uncharacterized protein	ISS			PTHR11280:SF8	GLUCOSAMINE-6-PHOSPHATE ISOMERASE 1
P00001	Adrenaline and noradrenaline biosynthesis	P00068	amine translocator	MOUSE|MGI=MGI=2143217|UniProtKB=Q8VDB9	Sodium- and chloride-dependent transporter XTRP3A	IC	12719981	PubMed	PTHR11616:SF44	SODIUM- AND CHLORIDE-DEPENDENT TRANSPORTER XTRP3
P00006	Apoptosis signaling pathway	P00303	c-Jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00019	Endothelin signaling pathway	P00568	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IGI	10395542	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	IDA	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P02775	Salvage pyrimidine ribonucleotides	P03153	Cytidylate kinase	DROME|FlyBase=FBgn0028833|UniProtKB=Q9VBI2	UMP-CMP kinase	ISS			PTHR23359:SF107	UMP-CMP KINASE
P00005	Angiogenesis	P00206	Wnt	DANRE|ZFIN=ZDB-GENE-980526-87|UniProtKB=Q92050	Protein Wnt-5b	ISS	11266476	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00036	Interleukin signaling pathway	P00976	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00010	B cell activation	P00376	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	91232861	PubMed	PTHR24070:SF385	GTPASE HRAS
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IPI	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00052	TGF-beta signaling pathway	P01275	P38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	TAS	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00049	Parkinson disease	P01211	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00058	mRNA splicing	P01476	U4	SCHPO|PomBase=SPAC29E6.02|UniProtKB=Q09856	U4/U5/U6 small nuclear ribonucleoprotein prp3	ISS			PTHR14212:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00170	Aph-1	BOVIN|Ensembl=ENSBTAG00000021482|UniProtKB=Q3SZ69	Anterior pharynx defective 1 homolog A (C. elegans)	ISS	12110170	PubMed	PTHR12889:SF3	GAMMA-SECRETASE SUBUNIT APH-1A
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	PANTR|Ensembl=ENSPTRG00000019474|UniProtKB=H2QV18	Uncharacterized protein	ISS			PTHR10221:SF12	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6
P00010	B cell activation	P00381	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00057	Wnt signaling pathway	P01443	Phospholipase C	CAEEL|WormBase=WBGene00004037|UniProtKB=Q9XWB7	Phosphoinositide phospholipase C	IDA	15611108	PubMed	PTHR10336:SF9	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00022	General transcription by RNA polymerase I	P00651	TAF-IA	ARATH|TAIR=AT5G15570|UniProtKB=Q9LF25	Bromodomain transcription factor	ISS			PTHR12321:SF53	BROMODOMAIN TRANSCRIPTION FACTOR
P02775	Salvage pyrimidine ribonucleotides	P03149	Cytidine kinase	HALSA|EnsemblGenome=VNG_1219G|UniProtKB=Q9HQC9	Uridine kinase	ISS			PTHR10285:SF6	ATP-DEPENDENT KINASE TDA10-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	PANTR|Ensembl=ENSPTRG00000002413|UniProtKB=H2Q1T1	Integrin beta	ISS	3487386	PubMed	PTHR10082:SF28	INTEGRIN BETA-1
P00017	DNA replication	P00527	Histones	TAKRU|Ensembl=ENSTRUG00000008082|UniProtKB=H2T664	Histone H3	ISS	12413958	PubMed	PTHR11426:SF167	HISTONE H3.1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-2280|UniProtKB=Q6P025	Gnb3 protein	ISS			PTHR19850:SF35	GNB3 PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00163	Erb-B4 C-terminal fragment	MOUSE|MGI=MGI=104771|UniProtKB=Q61527	Receptor tyrosine-protein kinase erbB-4	ISS	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	RAT|RGD=1359613|UniProtKB=Q66HA2	Cyclic AMP-responsive element-binding protein 3-like protein 1	ISS	608972	OMIM	PTHR22952:SF24	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CHICK|Ensembl=ENSGALG00000005410|UniProtKB=Q9YGX6	Protein Wnt	TAS	8717036	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	HUMAN|HGNC=7849|UniProtKB=P15531	Nucleoside diphosphate kinase A	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	TAS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00019	Endothelin signaling pathway	P00566	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000009766|UniProtKB=F6TFL4	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00007	Axon guidance mediated by semaphorins	P00333	RhoGEF	HUMAN|HGNC=681|UniProtKB=Q92888	Rho guanine nucleotide exchange factor 1	ISS	12024019	PubMed	PTHR12673:SF122	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 1
P00052	TGF-beta signaling pathway	P01284	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	HUMAN|HGNC=1401|UniProtKB=Q02641	Voltage-dependent L-type calcium channel subunit beta-1	IC	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00878	INFgamma	BOVIN|Ensembl=ENSBTAG00000012529|UniProtKB=P07353	Interferon gamma	TAS	11175845	PubMed	PTHR11419:SF0	INTERFERON GAMMA
P00049	Parkinson disease	P01212	p38 MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DROME|FlyBase=FBgn0001122|UniProtKB=P16378	G protein alpha o subunit	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01425	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00029	Huntington disease	P00790	beta-Tubulin	STRPU|EnsemblGenome=SPU_016007|UniProtKB=W4YJP3	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=7594|UniProtKB=Q9UKN7	Unconventional myosin-XV	IC			PTHR13140:SF379	UNCONVENTIONAL MYOSIN-XV
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05731	GABA-B receptor II signaling	P05760	AC	MOUSE|MGI=MGI=1341110|UniProtKB=P97490	Adenylate cyclase type 8	RCA	12890691	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00005	Angiogenesis	P00219	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	RAT|RGD=2626|UniProtKB=P12841	Proto-oncogene c-Fos	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00059	p53 pathway	P01485	p53	HUMAN|HGNC=12003|UniProtKB=O15350	Tumor protein p73	TAS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P06959	CCKR signaling map	G06980	HuR	HUMAN|HGNC=3312|UniProtKB=Q15717	ELAV-like protein 1	RCA	18395088	PubMed	PTHR43938:SF4	ELAV-LIKE PROTEIN 1
P00057	Wnt signaling pathway	P01438	PP2A	XENTR|Xenbase=XB-GENE-957248|UniProtKB=Q6GLE6	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00646	RasGAP	HUMAN|HGNC=9871|UniProtKB=P20936	Ras GTPase-activating protein 1	IGI	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00019	Endothelin signaling pathway	P00572	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00046	Oxidative stress response	P01129	JNK1/2	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	TAS	11707292	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00632	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	TAKRU|Ensembl=ENSTRUG00000016954|UniProtKB=H2V2J5	Uncharacterized protein	ISS	15226293	PubMed	PTHR13715:SF99	SUBFAMILY NOT NAMED
P00015	Circadian clock system	G01497	cry	MACMU|Ensembl=ENSMMUG00000021808|UniProtKB=F7ENG9	Cryptochrome-1	ISS	10428031	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00034	Integrin signalling pathway	P00924	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IPI	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00470	F-actin	MOUSE|MGI=MGI=87904|UniProtKB=P60710	Actin, cytoplasmic 1	IC	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00005	Angiogenesis	P00256	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	8687404	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	BOVIN|Ensembl=ENSBTAG00000004908|UniProtKB=P02715	Acetylcholine receptor subunit epsilon	IC			PTHR18945:SF59	ACETYLCHOLINE RECEPTOR SUBUNIT EPSILON
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P06959	CCKR signaling map	P07198	CaMKIV	HUMAN|HGNC=1464|UniProtKB=Q16566	Calcium/calmodulin-dependent protein kinase type IV	RCA	10535305	PubMed	PTHR24349:SF152	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE IV
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000006232|UniProtKB=H2Q845	Serine/threonine-protein kinase	ISS	12393506	PubMed	PTHR22968:SF9	SERINE/THREONINE-PROTEIN KINASE D1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P02738	De novo purine biosynthesis	P02902	ADP reductase	NEUCR|EnsemblGenome=EFNCRG00000007504|UniProtKB=Q9C167	Ribonucleoside-diphosphate reductase small chain	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00759	PDEalphabeta	MACMU|Ensembl=ENSMMUG00000003282|UniProtKB=F7GPA8	Phosphodiesterase	ISS	P35913	SPACC	PTHR11347:SF73	ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT BETA
P06214	GBB signaling pathway	P06299	MED	DROME|FlyBase=FBgn0011655|UniProtKB=O62609	Mothers against decapentaplegic homolog	IEA	http://flybase.org/reports/FBgn0011655.html	Website	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P00056	VEGF signaling pathway	P01415	MAPKAPK2/3	MACMU|Ensembl=ENSMMUG00000023567|UniProtKB=F7HHY8	Uncharacterized protein	ISS	7923354	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01435	SWI/SNF	PANTR|Ensembl=ENSPTRG00000014875|UniProtKB=H2QMI4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	ISS	11532957	PubMed	PTHR12802:SF9	SWI/SNF COMPLEX SUBUNIT SMARCC1
P06587	Nicotine pharmacodynamics pathway	P06605	KCNK3/9	BOVIN|Ensembl=ENSBTAG00000047488|UniProtKB=G3N1D1	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P02738	De novo purine biosynthesis	P02907	dADP kinase	LEIMA|EnsemblGenome=LmjF.32.2950|UniProtKB=Q9U1E1	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	HUMAN|HGNC=16833|UniProtKB=O14544	Suppressor of cytokine signaling 6	TAS	12645661	PubMed	PTHR44562:SF1	SUPPRESSOR OF CYTOKINE SIGNALING 6
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	HUMAN|HGNC=10935|UniProtKB=Q05940	Synaptic vesicular amine transporter	ISS	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=101848|UniProtKB=P62881	Guanine nucleotide-binding protein subunit beta-5	IC	9754712	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CAEEL|WormBase=WBGene00000066|UniProtKB=P10986	Actin-4	ISS	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00009	Axon guidance mediated by netrin	P00363	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00010	B cell activation	P00380	fos	BOVIN|Ensembl=ENSBTAG00000004322|UniProtKB=O77628	Proto-oncogene c-Fos	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00539	14-3-3	TAKRU|Ensembl=ENSTRUG00000004697|UniProtKB=H2SFG7	Uncharacterized protein	ISS	1317796	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	DANRE|ZFIN=ZDB-GENE-030616-53|UniProtKB=Q71E60	AMPA receptor subunit GluR3B	ISS	10331083	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00005	Angiogenesis	P00237	FRP	HUMAN|HGNC=4038|UniProtKB=Q9UP38	Frizzled-1	IC	11212302	PubMed	PTHR11309:SF81	FRIZZLED-1
P00034	Integrin signalling pathway	P00920	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	SCHPO|PomBase=SPCC1223.13|UniProtKB=O74412	Transcription factor cbf12	NAS			PTHR10665:SF0	SUPPRESSOR OF HAIRLESS PROTEIN
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00018	EGF receptor signaling pathway	P00551	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00251	cPLA2	MACMU|Ensembl=ENSMMUG00000003842|UniProtKB=F7HAF3	Phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF32	CYTOSOLIC PHOSPHOLIPASE A2 BETA
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ORYSJ|EnsemblGenome=OS05G0371200|UniProtKB=Q60EW3	Os05g0371200 protein	ISS	15237785	gi	PTHR10410:SF5	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 14
P00047	PDGF signaling pathway	P01159	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00021	FGF signaling pathway	P00627	ERK1-2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DROME|FlyBase=FBgn0000489|UniProtKB=P16912	Protein kinase DC2	IC	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00054	Toll receptor signaling pathway	P01352	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00243	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00014	Cholesterol biosynthesis	P00496	Diphosphomevalonate decarboxylase	CAEEL|WormBase=WBGene00012984|UniProtKB=Q9U294	Uncharacterized protein	ISS	4505289	gi	PTHR10977:SF3	DIPHOSPHOMEVALONATE DECARBOXYLASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01432	Beta-Catenin	HUMAN|HGNC=2514|UniProtKB=P35222	Catenin beta-1	IDA	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00018	EGF receptor signaling pathway	P00547	PP2A	HUMAN|HGNC=9299|UniProtKB=P67775	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	IGI	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01407	Erk	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00010	B cell activation	P00371	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00223	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00910	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	11384839	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000006495|UniProtKB=P11017	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00060	Ubiquitin proteasome pathway	P01490	E3	RAT|RGD=1310091|UniProtKB=F7EYF1	E3 ubiquitin-protein ligase	ISS			PTHR11254:SF396	NEDD4-LIKE E3 UBIQUITIN-PROTEIN LIGASE WWP2
P02788	Xanthine and guanine salvage pathway	P03249	Guanine deaminase	ECOLI|EcoGene=EG13066|UniProtKB=P76641	Guanine deaminase	ISS			PTHR11271:SF6	GUANINE DEAMINASE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00029	Huntington disease	P00805	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05918	p38 MAPK pathway	P06031	p38alpha	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00034	Integrin signalling pathway	P00948	Rho	CAEEL|WormBase=WBGene00004357|UniProtKB=Q22038	Ras-like GTP-binding protein rhoA	IGI	7798239	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MONDO|Ensembl=ENSMODG00000024440|UniProtKB=F7DJJ2	Muscarinic acetylcholine receptor	ISS	8100450	PubMed	PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00010	B cell activation	P00397	IKK	BOVIN|Ensembl=ENSBTAG00000007591|UniProtKB=Q95KV1	Inhibitor of nuclear factor kappa-B kinase subunit alpha	IGI	12235208	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04651	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00060	Ubiquitin proteasome pathway	P01491	E2	ORYSJ|EnsemblGenome=OS01G0673600|UniProtKB=Q8W0I1	Os01g0673600 protein	ISS			PTHR43902:SF2	UBIQUITIN-CONJUGATING ENZYME E2 N
P00048	PI3 kinase pathway	P01193	IRS	MOUSE|MGI=MGI=99454|UniProtKB=P35569	Insulin receptor substrate 1	IDA	5031805	gi	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00057	Wnt signaling pathway	P01465	Ggamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	MOUSE|MGI=MGI=87885|UniProtKB=P04756	Acetylcholine receptor subunit alpha	ISS	85270494	PubMed	PTHR18945:SF74	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IC	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00053	T cell activation	P01319	PAK	XENTR|Xenbase=XB-GENE-961764|UniProtKB=F6W3Y0	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00034	Integrin signalling pathway	P00951	Jnk	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00054	Toll receptor signaling pathway	P01351	TLR2,4,7	PANTR|Ensembl=ENSPTRG00000028318|UniProtKB=H2R4T7	Uncharacterized protein	ISS			PTHR44312:SF1	TOLL-LIKE RECEPTOR 7
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00059	p53 pathway	P04633	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	RAT|RGD=70938|UniProtKB=G3V6S7	Protein Il5ra	IEP	11606047	PubMed	PTHR23036:SF17	INTERLEUKIN-5 RECEPTOR SUBUNIT ALPHA
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00633	Ras	DICDI|dictyBase=DDB_G0281385|UniProtKB=P32253	Ras-like protein rasC	IDA	8290260	PubMed	PTHR24070:SF251	RAS-LIKE PROTEIN RASC
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	TAKRU|Ensembl=ENSTRUG00000011297|UniProtKB=H2TV18	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	PANTR|Ensembl=ENSPTRG00000014922|UniProtKB=H2QML4	Uncharacterized protein	ISS	12039949	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00018	EGF receptor signaling pathway	P00555	MKK4,7	PANTR|Ensembl=ENSPTRG00000010409|UniProtKB=H2RBC8	Uncharacterized protein	ISS	15039780	PubMed	PTHR24361:SF387	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7
P00046	Oxidative stress response	P01134	cPLA2	CANLF|Ensembl=ENSCAFG00000013778|UniProtKB=F6UQ33	Phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00023	General transcription regulation	P00669	TFIIEalpha	HUMAN|HGNC=4650|UniProtKB=P29083	General transcription factor IIE subunit 1	IGI	92065982	PubMed	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P05916	Opioid prodynorphin pathway	P06000	vasopressin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	ARATH|TAIR=AT2G37250|UniProtKB=Q9ZUU1	Adenylate kinase 1, chloroplastic	ISS			PTHR23359:SF94	ADENYLATE KINASE 1, CHLOROPLASTIC
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF31	SUBFAMILY NOT NAMED
P02776	Serine glycine biosynthesis	P03159	Phosphoserine phosphatase	PANTR|Ensembl=ENSPTRG00000019205|UniProtKB=H2QUL8	Phosphoserine phosphatase	ISS			PTHR43344:SF2	PHOSPHOSERINE PHOSPHATASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01199	Galpha	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	IC	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00589	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	IGI	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00637	MKK4,7	HUMAN|HGNC=6844|UniProtKB=P45985	Dual specificity mitogen-activated protein kinase kinase 4	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P02749	Leucine biosynthesis	P02999	2-Isopropylmalate synthase	ARATH|TAIR=AT5G23010|UniProtKB=Q9FG67	Methylthioalkylmalate synthase 1, chloroplastic	ISS			PTHR10277:SF9	2-ISOPROPYLMALATE SYNTHASE 1, CHLOROPLASTIC-RELATED
P00005	Angiogenesis	P00243	Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	ISS	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	CAEEL|WormBase=WBGene00003911|UniProtKB=Q17850	Serine/threonine-protein kinase pak-1	ISS			PTHR24361:SF456	P21-ACTIVATED KINASE, ISOFORM F
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00060	Ubiquitin proteasome pathway	P01494	19S proteasome	SCHPO|PomBase=SPCC576.10c|UniProtKB=O74894	26S protease regulatory subunit 6B homolog	ISS			PTHR23073:SF8	26S PROTEASE REGULATORY SUBUNIT 6B
P00053	T cell activation	P01332	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	IDA	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00017	DNA replication	P00534	PCNA	METAC|EnsemblGenome=MA_0110|UniProtKB=Q8TUF7	DNA polymerase sliding clamp	ISS	21929760	PubMed	PTHR11352:SF0	PROLIFERATING CELL NUCLEAR ANTIGEN
P00029	Huntington disease	P00805	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000002016|UniProtKB=F1P3G1	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00046	Oxidative stress response	P01137	MNK1/2	BOVIN|Gene=MKNK1|UniProtKB=Q58D94	MAP kinase-interacting serine/threonine-protein kinase 1	ISS	9155017	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05731	GABA-B receptor II signaling	P05755	Gbeta	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00005	Angiogenesis	P00182	p38MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05731	GABA-B receptor II signaling	P05753	Ca channel	RAT|RGD=628852|UniProtKB=Q02294	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	11976940	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00034	Integrin signalling pathway	P00907	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	98269030	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CHICK|Ensembl=ENSGALG00000003270|UniProtKB=F1NR31	Uncharacterized protein	IDA			PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00010	B cell activation	P00384	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00002	Alpha adrenergic receptor signaling pathway	P00078	Alpha1A/1B/1C	MOUSE|MGI=MGI=104774|UniProtKB=P97717	Alpha-1B adrenergic receptor	IC	11781138	PubMed	PTHR24248:SF17	ALPHA-1B ADRENERGIC RECEPTOR
P00029	Huntington disease	P00780	Microtubule	MACMU|Ensembl=ENSMMUG00000013187|UniProtKB=F6XQ37	Tubulin beta-1 chain	ISS	12932731	PubMed	PTHR11588:SF112	TUBULIN BETA-1 CHAIN
P00012	Cadherin signaling pathway	P00470	F-actin	CHICK|Ensembl=ENSGALG00000009621|UniProtKB=P60706	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04395	Vasopressin synthesis	P04594	Neurophysin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Gene=DRD2|UniProtKB=P60026	D(2) dopamine receptor	ISS	11861492	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CANLF|Ensembl=ENSCAFG00000000332|UniProtKB=F1P8E3	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00010	B cell activation	P00384	p38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	IDA	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	HUMAN|HGNC=4544|UniProtKB=P34947	G protein-coupled receptor kinase 5	RCA			PTHR24355:SF27	G PROTEIN-COUPLED RECEPTOR KINASE 5
P00009	Axon guidance mediated by netrin	P00366	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00029	Huntington disease	P00807	Actin	ORNAN|Ensembl=ENSOANG00000007405|UniProtKB=F7CIV4	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00572	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CAEEL|WormBase=WBGene00006454|UniProtKB=G5EEN8	AEX-4	IC			PTHR19305:SF10	AEX-4
P04393	Ras Pathway	P04567	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	PANTR|Ensembl=ENSPTRG00000013022|UniProtKB=H2QJL0	Uncharacterized protein	ISS	11859080	PubMed	PTHR24247:SF31	5-HYDROXYTRYPTAMINE RECEPTOR 2B
P00005	Angiogenesis	P00231	HSP27	MOUSE|MGI=MGI=96240|UniProtKB=P14602	Heat shock protein beta-1	RCA			PTHR11527:SF114	HEAT SHOCK PROTEIN BETA-1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	DANRE|ZFIN=ZDB-GENE-020125-4|UniProtKB=F1QKT1	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IGI	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05918	p38 MAPK pathway	P06036	MKK3	ORNAN|Ensembl=ENSOANG00000007732|UniProtKB=F6PXH5	Uncharacterized protein (Fragment)	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00018	EGF receptor signaling pathway	P00539	14-3-3	CAEBR|Gene=CBG17289|UniProtKB=A8XQR9	14-3-3 zeta	ISS	97315111	PubMed	PTHR18860:SF13	14-3-3 PROTEIN ZETA
P00057	Wnt signaling pathway	P01443	Phospholipase C	CAEEL|WormBase=WBGene00004037|UniProtKB=Q9XWB7	Phosphoinositide phospholipase C	IDA	7822322	PubMed	PTHR10336:SF9	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	RAT|RGD=1307904|UniProtKB=M0RAI4	Protein Ears2	ISS			PTHR43311:SF2	GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	MACMU|Ensembl=ENSMMUG00000008569|UniProtKB=F6UPU0	Uncharacterized protein	ISS	20355009	PubMed	PTHR15319:SF1	TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT C
P00056	VEGF signaling pathway	P01425	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	3755548	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00021	FGF signaling pathway	P00627	ERK1-2	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	NAS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04455	beta-endorphin	MOUSE|MGI=MGI=97742|UniProtKB=P01193	Pro-opiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00057	Wnt signaling pathway	P01451	Galpha	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00024	Glycolysis	P00678	Enolase	BOVIN|Gene=ENO1|UniProtKB=Q9XSJ4	Alpha-enolase	ISS	99439677	PubMed	PTHR11902:SF12	ALPHA-ENOLASE
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=1758|UniProtKB=Q9H159	Cadherin-19	IDA	8120095	PubMed	PTHR24027:SF323	CADHERIN-19
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00049	Parkinson disease	P01227	20S proteasome	DANRE|ZFIN=ZDB-GENE-020326-1|UniProtKB=Q7SXN6	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF11	PROTEASOME SUBUNIT ALPHA TYPE-6
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	HUMAN|HGNC=17175|UniProtKB=Q9P212	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	12860966	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00053	T cell activation	P01336	Jnk	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IGI	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00045	Notch signaling pathway	P01110	Presenilin	BOVIN|Ensembl=ENSBTAG00000011757|UniProtKB=Q9XT97	Presenilin-1	ISS	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IGI	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00019	Endothelin signaling pathway	P00572	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00624	14-3-3	CANLF|Ensembl=ENSCAFG00000013549|UniProtKB=E2QVP6	Uncharacterized protein	ISS	1317796	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00870	IL2	MOUSE|MGI=MGI=107936|UniProtKB=P70380	Interleukin-18	IDA			PTHR45200:SF1	INTERLEUKIN-18
P00036	Interleukin signaling pathway	P00990	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	DICDI|dictyBase=DDB_G0293434|UniProtKB=P15064	Ras-like protein rasG	ISS	7997267	PubMed	PTHR24070:SF282	RAS GTPASE-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	RAT|RGD=2746|UniProtKB=P31424	Metabotropic glutamate receptor 5	IDA	14614461	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00012	Cadherin signaling pathway	P00477	GSK3beta	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00047	PDGF signaling pathway	P01167	Ets	BOVIN|Ensembl=ENSBTAG00000002341|UniProtKB=A5PJG9	ETS1 protein	ISS	3060801	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	PANTR|Ensembl=ENSPTRG00000004718|UniProtKB=H2Q5I0	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P02729	Ascorbate degradation	P02849	L-xylulose kinase	THEMA|EnsemblGenome=TM_0116|UniProtKB=Q9WXX1	Sugar kinase, FGGY family	ISS			PTHR43095:SF5	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MACMU|Ensembl=ENSMMUG00000001661|UniProtKB=F7GR69	Uncharacterized protein	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00006	Apoptosis signaling pathway	P00273	p53	RAT|RGD=3889|UniProtKB=P10361	Cellular tumor antigen p53	ISS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	RAT|RGD=3921|UniProtKB=P45352	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P02736	Coenzyme A biosynthesis	P02882	Pantothenate cysteine ligase	THEMA|EnsemblGenome=TM_1687|UniProtKB=Q9X213	DNA/pantothenate metabolism flavoprotein	ISS			PTHR14359:SF6	PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE
P00049	Parkinson disease	P01219	SAPK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEEL|WormBase=WBGene00004033|UniProtKB=P90980	Protein kinase C-like 2	ISS	3045562	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00021	FGF signaling pathway	P00643	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_125401|UniProtKB=C3ZTX6	Putative uncharacterized protein	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00029	Huntington disease	P00775	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	IC	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	HUMAN|HGNC=14079|UniProtKB=Q9UGM1	Neuronal acetylcholine receptor subunit alpha-9	IC			PTHR18945:SF489	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-9
P00019	Endothelin signaling pathway	P00570	PKA	LEIMA|EnsemblGenome=LmjF.15.1200|UniProtKB=Q4QF64	Uncharacterized protein	ISS	188830	OMIM	PTHR24361:SF625	SPORULATION-SPECIFIC PROTEIN 1
P00010	B cell activation	P00398	IP3R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P05913	Enkephalin release	P05977	G-Protein (s)	MACMU|Ensembl=ENSMMUG00000010392|UniProtKB=F7ASR8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00047	PDGF signaling pathway	P01162	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06705	PLCbeta	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	RCA	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00048	PI3 kinase pathway	P01205	NOS	CANLF|Gene=NOS3|UniProtKB=Q9TUX8	Nitric oxide synthase, endothelial	ISS	10435050	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00577	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01433	SIAH-1	DROME|FlyBase=FBgn0259794|UniProtKB=Q8T3Y0	Probable E3 ubiquitin-protein ligase sinah	ISS	11389839	PubMed	PTHR10315:SF70	E3 UBIQUITIN-PROTEIN LIGASE SINA-RELATED
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	YEAST|SGD=S000003572|UniProtKB=P47058	tRNA-specific adenosine deaminase subunit TAD2	ISS			PTHR11079:SF92	TRNA-SPECIFIC ADENOSINE DEAMINASE 2
P00053	T cell activation	P01335	jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00036	Interleukin signaling pathway	P00996	STAT	MACMU|Ensembl=ENSMMUG00000010707|UniProtKB=F7G8G5	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DICPU|Gene=DICPUDRAFT_92985|UniProtKB=F1A084	Putative uncharacterized protein rac1A	ISS	21127961	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	PANTR|Ensembl=ENSPTRG00000005006|UniProtKB=H2Q615	Integrin beta	ISS	10741397	PubMed	PTHR10082:SF36	INTEGRIN BETA-7
P00021	FGF signaling pathway	P00632	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	CAEBR|Gene=CBG02401|UniProtKB=A8WUE7	Protein CBR-NMR-1	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00059	p53 pathway	G04692	R2	RAT|RGD=2323655|UniProtKB=D4A7M6	Protein LOC100359539	ISS			PTHR23409:SF20	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00036	Interleukin signaling pathway	P00982	p27KIP1	MACMU|Ensembl=ENSMMUG00000022370|UniProtKB=F6Z4R0	Cyclin-dependent kinase inhibitor 1B	ISS			PTHR10265:SF9	CYCLIN-DEPENDENT KINASE INHIBITOR 1B
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	HUMAN|HGNC=7883|UniProtKB=Q9UM47	Neurogenic locus notch homolog protein 3	IDA	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00036	Interleukin signaling pathway	P00996	STAT	MACMU|Ensembl=ENSMMUG00000010707|UniProtKB=F7G8G5	Signal transducer and activator of transcription	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00057	Wnt signaling pathway	P01440	Cadherin	BOVIN|Ensembl=ENSBTAG00000021497|UniProtKB=F1MXP9	Uncharacterized protein	ISS	8120095	PubMed	PTHR43956:SF3	CADHERIN-23
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00709	Glycogen synthase D	MOUSE|MGI=MGI=101805|UniProtKB=Q9Z1E4	Glycogen [starch] synthase, muscle	IDA	4212312	PubMed	PTHR10176:SF2	GLYCOGEN  STARCH  SYNTHASE, MUSCLE
P00021	FGF signaling pathway	P00623	FGF	MOUSE|MGI=MGI=1277980|UniProtKB=O89101	Fibroblast growth factor 18	ISS	12738892	PubMed	PTHR11486:SF4	FIBROBLAST GROWTH FACTOR 18
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00975	RasGAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	11847220	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00054	Toll receptor signaling pathway	P01368	MKK2	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	TAKRU|Ensembl=ENSTRUG00000015959|UniProtKB=H2UV27	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	MOUSE|MGI=MGI=88296|UniProtKB=O55017	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	15079861	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	MOUSE|MGI=MGI=95814|UniProtKB=Q60934	Glutamate receptor ionotropic, kainate 1	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00021	FGF signaling pathway	P00641	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00029	Huntington disease	P00775	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	20010089	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00047	PDGF signaling pathway	P01161	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	IDA	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	TAKRU|Ensembl=ENSTRUG00000008018|UniProtKB=H2T5N4	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000005917|UniProtKB=F6QM53	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00023	General transcription regulation	P00668	TFIIB	IXOSC|EnsemblGenome=ISCW009067|UniProtKB=B7Q0X0	Putative uncharacterized protein	ISS			PTHR12458:SF8	CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05916	Opioid prodynorphin pathway	P06002	G-protein	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00006	Apoptosis signaling pathway	P00260	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00629	PP2A	BOVIN|Ensembl=ENSBTAG00000000469|UniProtKB=P67774	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P02777	Succinate to proprionate conversion	P03161	Methylmalonyl-CoA mutase	DEIRA|EnsemblGenome=DR_1189|UniProtKB=Q9RV41	Methylmalonyl-CoA mutase, alpha subunit, chain A	ISS			PTHR43589:SF3	SUBFAMILY NOT NAMED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	RCA	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01314	nck	HUMAN|HGNC=7664|UniProtKB=P16333	Cytoplasmic protein NCK1	IPI	12874226	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P00029	Huntington disease	P00807	Actin	CANLF|Ensembl=ENSCAFG00000012181|UniProtKB=F2Z4N7	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00048	PI3 kinase pathway	P01199	Galpha	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	IC	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00023	General transcription regulation	P00659	TFIIEbeta	DROME|FlyBase=FBgn0015829|UniProtKB=O96881	Transcription initiation factor IIE subunit beta	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00021	FGF signaling pathway	P00642	MEK1-2	CAEEL|WormBase=WBGene00003186|UniProtKB=Q10664	Dual specificity mitogen-activated protein kinase kinase mek-2	IGI	17508425	gi	PTHR24361:SF629	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	DROME|FlyBase=FBgn0010399|UniProtKB=Q24418	Glutamate [NMDA] receptor subunit 1	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00059	p53 pathway	P04630	PP2A	TRIAD|EnsemblGenome=TriadG63380|UniProtKB=B3S653	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00474	Wnt	PANTR|Ensembl=ENSPTRG00000019617|UniProtKB=Q2QLE7	Protein Wnt-2	ISS	8717036	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IGI	7937853	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00049	Parkinson disease	P01227	20S proteasome	DICDI|dictyBase=DDB_G0282363|UniProtKB=Q27562	Proteasome subunit alpha type-1	TAS	12859888	PubMed	PTHR11599:SF12	PROTEASOME SUBUNIT ALPHA TYPE-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000009389|UniProtKB=F7HEV7	Uncharacterized protein	ISS	12093103	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00559	MEK1-2	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04393	Ras Pathway	P04572	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00049	Parkinson disease	P01236	Casein kinase II	IXOSC|EnsemblGenome=ISCW014459|UniProtKB=B7QIS2	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IGI	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	BOVIN|Gene=CSNK2A1|UniProtKB=P68399	Casein kinase II subunit alpha	ISS	10806215	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00012	Cadherin signaling pathway	P00477	GSK3beta	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	HUMAN|HGNC=11773|UniProtKB=P37173	TGF-beta receptor type-2	TAS	9395284	PubMed	PTHR23255:SF55	TGF-BETA RECEPTOR TYPE-2
P00005	Angiogenesis	P00199	JNKK1	MACMU|Ensembl=ENSMMUG00000019842|UniProtKB=F7FU91	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	MOUSE|MGI=MGI=95815|UniProtKB=P39087	Glutamate receptor ionotropic, kainate 2	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IC	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	ANOGA|EnsemblGenome=AGAP005911|UniProtKB=Q7Q6D4	AGAP005911-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00052	TGF-beta signaling pathway	P01292	RSmads	HUMAN|HGNC=6767|UniProtKB=Q15797	Mothers against decapentaplegic homolog 1	TAS	9395284	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	RAT|RGD=2522|UniProtKB=P30729	D(4) dopamine receptor	ISS	12181435	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P02738	De novo purine biosynthesis	P02904	Guanylate kinase	THEMA|EnsemblGenome=TM_1689|UniProtKB=Q9X215	Guanylate kinase	ISS			PTHR23117:SF13	GUANYLATE KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	RAT|RGD=2155|UniProtKB=O88656	Actin-related protein 2/3 complex subunit 1B	ISS	12932731	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	HUMAN|HGNC=1404|UniProtKB=O00305	Voltage-dependent L-type calcium channel subunit beta-4	IC			PTHR11824:SF7	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00035	Interferon-gamma signaling pathway	P00952	Jak2	PANTR|Ensembl=ENSPTRG00000020744|UniProtKB=H2QWZ4	Tyrosine-protein kinase	ISS	22482294	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P06210	Activin beta signaling pathway	P06236	SMOX	DROME|FlyBase=FBgn0025800|UniProtKB=O96660	Mothers against decapentaplegic homolog	IEA	9395284	PubMed	PTHR13703:SF25	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3
P06217	Toll pathway-drosophila	P06347	SPZ full length	DROME|FlyBase=FBgn0003495|UniProtKB=P48607	Protein spaetzle	IDA	8124709	PubMed	PTHR23199:SF12	NEUROTROPHIN 1, ISOFORM F-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00640	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	IGI	96320556	PubMed	PTHR10048:SF14	PI-3 KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06794	MAP2K1/2	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	RCA	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04393	Ras Pathway	P04547	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=108059|UniProtKB=Q00262	Syntaxin-2	ISS	12737809	PubMed	PTHR19957:SF36	SYNTAXIN-2
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02783	Tryptophan biosynthesis	P03207	Tryptophan synthase A	BACTN|EnsemblGenome=BT_0527|UniProtKB=Q8AAD8	Tryptophan synthase alpha chain	ISS			PTHR43455:SF1	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	HUMAN|HGNC=6012|UniProtKB=P26951	Interleukin-3 receptor subunit alpha	IGI	12943658	PubMed	PTHR23036:SF107	INTERLEUKIN-3 RECEPTOR SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00833	RGS	RAT|RGD=3567|UniProtKB=P49799	Regulator of G-protein signaling 4	ISS	9774420	PubMed	PTHR10845:SF184	REGULATOR OF G-PROTEIN SIGNALING 4
P00054	Toll receptor signaling pathway	P01369	MKK1	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	TAS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00005	Angiogenesis	P00249	PAK	MONDO|Ensembl=ENSMODG00000005255|UniProtKB=F7G800	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	DANRE|ZFIN=ZDB-GENE-081124-1|UniProtKB=F1QVX3	Uncharacterized protein	ISS			PTHR13140:SF728	MYOSIN HEAVY CHAIN, SKELETAL MUSCLE, ADULT
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	SCHPO|PomBase=SPAC6G9.11|UniProtKB=Q92356	Synaptobrevin homolog 1	IC			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00010	B cell activation	P00402	Jnk	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=1560850|UniProtKB=F1LNJ8	Protein Pik3r6	ISS			PTHR15593:SF1	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 6
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000026580|UniProtKB=F1MB93	Uncharacterized protein	ISS	1608964	PubMed	PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P00029	Huntington disease	P00807	Actin	MOUSE|MGI=MGI=87909|UniProtKB=P62737	Actin, aortic smooth muscle	IDA	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	HUMAN|HGNC=1389|UniProtKB=Q00975	Voltage-dependent N-type calcium channel subunit alpha-1B	TAS	14624853	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00010	B cell activation	P00398	IP3R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	IGI	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	PANTR|Ensembl=ENSPTRG00000004090|UniProtKB=H2Q4F7	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01312	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IDA	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00790	beta-Tubulin	STRPU|EnsemblGenome=SPU_003894|UniProtKB=W4XKG7	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF155	TUBULIN BETA-2 CHAIN
P00021	FGF signaling pathway	P00644	p38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	ENTHI|EnsemblGenome=EHI_137700|UniProtKB=Q24806	Ras family GTPase	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	HUMAN|HGNC=289|UniProtKB=P25098	Beta-adrenergic receptor kinase 1	RCA			PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	IXOSC|EnsemblGenome=ISCW009711|UniProtKB=B7Q3T6	THO complex subunit, putative	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00210	eNOS	HUMAN|HGNC=7876|UniProtKB=P29474	Nitric oxide synthase, endothelial	IEP	22462730	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00111	C99	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=3047|UniProtKB=Q63454	Mitogen-activated protein kinase 4 (Fragment)	ISS	10514528	PubMed	PTHR24055:SF25	MITOGEN-ACTIVATED PROTEIN KINASE 4
P00018	EGF receptor signaling pathway	P00545	JNK1-3	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IGI	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	MOUSE|MGI=MGI=1351343|UniProtKB=Q5NCH9	Metabotropic glutamate receptor 6	ISS	12351712	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02747	Histidine biosynthesis	P02993	Phosphoribosylformimino-5-amino-1-phosphoribosyl-4 imadazol carboxamide isomerase	AQUAE|EnsemblGenome=aq_1303|UniProtKB=O67328	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase	ISS			PTHR43090:SF2	1- 5-PHOSPHORIBOSYL -5-  5-PHOSPHORIBOSYLAMINO METHYLIDENEAMINO  IMIDAZOLE-4-CARBOXAMIDE ISOMERASE
P00037	Ionotropic glutamate receptor pathway	P01001	KA4	HUMAN|HGNC=4582|UniProtKB=Q16099	Glutamate receptor ionotropic, kainate 4	IC	12941441	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00006	Apoptosis signaling pathway	P00310	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	RCA	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00005	Angiogenesis	P00221	JNK1	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00049	Parkinson disease	P01219	SAPK	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	8925912	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	MACMU|Ensembl=ENSMMUG00000000135|UniProtKB=F7H624	Excitatory amino acid transporter 3	ISS	94365697	PubMed	PTHR11958:SF69	EXCITATORY AMINO ACID TRANSPORTER 3
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	MOUSE|MGI=MGI=1338944|UniProtKB=Q61271	Activin receptor type-1B	TAS	9395284	PubMed	PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	MONDO|Ensembl=ENSMODG00000012785|UniProtKB=F6S0M5	Uncharacterized protein	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P05916	Opioid prodynorphin pathway	P06000	vasopressin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=15983|UniProtKB=P56704	Protein Wnt-3a	TAS	11266476	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	DANRE|ZFIN=ZDB-GENE-030131-8013|UniProtKB=F1QBT6	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00048	PI3 kinase pathway	P01192	p110	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P02775	Salvage pyrimidine ribonucleotides	P03153	Cytidylate kinase	CAEEL|WormBase=WBGene00009575|UniProtKB=Q20230	UMP-CMP kinase 2	ISS			PTHR23359:SF114	UMP-CMP KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	PANTR|Ensembl=ENSPTRG00000021362|UniProtKB=H2QXW1	Actin-related protein 2/3 complex subunit 5	ISS	12473693	PubMed	PTHR12644:SF2	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5-LIKE PROTEIN
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	ARATH|TAIR=AT2G16370|UniProtKB=Q05762	Bifunctional dihydrofolate reductase-thymidylate synthase 1	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	BOVIN|Ensembl=ENSBTAG00000019337|UniProtKB=F1MMW7	Receptor protein serine/threonine kinase	ISS	10683140	PubMed	PTHR23255:SF58	ACTIVIN RECEPTOR TYPE-1C
P04395	Vasopressin synthesis	P04593	Glycopeptide	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00034	Integrin signalling pathway	P00906	Rap1	MACMU|Ensembl=ENSMMUG00000011442|UniProtKB=F7B9T3	Ras-related protein Rap-1b	ISS	8576107	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	ISS	94131270	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00049	Parkinson disease	P01219	SAPK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Ensembl=ENSCAFG00000009203|UniProtKB=F1PVZ1	Muscarinic acetylcholine receptor	ISS	8100450	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	ISS	7925653	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01414	PLC-gamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00047	PDGF signaling pathway	P01160	IP3 receptor	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DICPU|Gene=DICPUDRAFT_46519|UniProtKB=F0Z796	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P06214	GBB signaling pathway	P06306	WIT	DROME|FlyBase=FBgn0024179|UniProtKB=M9PE88	Receptor protein serine/threonine kinase	IDA	11856529	PubMed	PTHR23255:SF52	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	HUMAN|HGNC=4586|UniProtKB=Q13224	Glutamate receptor ionotropic, NMDA 2B	IC	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00006	Apoptosis signaling pathway	P00260	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04396	Vitamin D metabolism and pathway	P04606	VDR	MOUSE|MGI=MGI=103076|UniProtKB=P48281	Vitamin D3 receptor	IDA	11705326	PubMed	PTHR24082:SF38	VITAMIN D3 RECEPTOR
P00030	Hypoxia response via HIF activation	P00819	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	BOVIN|Ensembl=ENSBTAG00000006495|UniProtKB=P11017	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MONDO|Ensembl=ENSMODG00000013667|UniProtKB=F6TXD9	Adenylosuccinate synthetase isozyme 1	ISS	10636885	PubMed	PTHR11846:SF2	ADENYLOSUCCINATE SYNTHETASE ISOZYME 1
P00005	Angiogenesis	P00243	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	10693759	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ORNAN|Ensembl=ENSOANG00000007716|UniProtKB=F6UDX9	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00056	VEGF signaling pathway	P01417	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00914	Filamin	MOUSE|MGI=MGI=2446089|UniProtKB=Q80X90	Filamin-B	ISS	9722563	PubMed	PTHR43998:SF3	FILAMIN-B
P00047	PDGF signaling pathway	P01168	PI3K	XENTR|Xenbase=XB-GENE-6067221|UniProtKB=F6Z0J4	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	CHICK|Ensembl=ENSGALG00000011452|UniProtKB=F1P1K3	Uncharacterized protein	ISS	12473693	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P02738	De novo purine biosynthesis	P02894	IMP cyclohydrolase	MOUSE|MGI=MGI=1351352|UniProtKB=Q9CWJ9	Bifunctional purine biosynthesis protein PURH	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IDA	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00008	Axon guidance mediated by Slit/Robo	P00355	Rho	HUMAN|HGNC=669|UniProtKB=P08134	Rho-related GTP-binding protein RhoC	ISS	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P06959	CCKR signaling map	P07098	p46 SHC1	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	RCA	11607835	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00053	T cell activation	P01309	fos	PANTR|Ensembl=ENSPTRG00000006553|UniProtKB=A5A6H0	C-fos	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00011	Blood coagulation	P00406	Fibrinogen	HUMAN|HGNC=3662|UniProtKB=P02675	Fibrinogen beta chain	ISS	11761631	gi	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00048	PI3 kinase pathway	P01179	PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	DANRE|ZFIN=ZDB-GENE-040808-67|UniProtKB=Q6AZA4	K-ras	ISS	20362513	PubMed	PTHR24070:SF186	GTPASE KRAS
P00053	T cell activation	P01300	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00139	E-cadherin transmembrane fragment	MOUSE|MGI=MGI=88354|UniProtKB=P09803	Cadherin-1	IDA	11953314	PubMed	PTHR24027:SF319	CADHERIN-1
P00005	Angiogenesis	P00238	Ras	DICDI|dictyBase=DDB_G0292998|UniProtKB=P32252	Ras-like protein rasB	ISS			PTHR24070:SF206	RAS-LIKE PROTEIN RASB
P04398	p53 pathway feedback loops 2	P04651	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00010	B cell activation	P00376	Ras	PANTR|Ensembl=ENSPTRG00000034469|UniProtKB=H2Q2V0	Uncharacterized protein	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000023046|UniProtKB=F6V829	Uncharacterized protein	ISS	11431030	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	PANTR|Ensembl=ENSPTRG00000023608|UniProtKB=H2QZZ2	Uncharacterized protein	ISS	11319238	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	14744463	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	PANTR|Ensembl=ENSPTRG00000009518|UniProtKB=H2QDN0	Mitogen-activated protein kinase kinase kinase 3	ISS	11730323	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	ORNAN|Ensembl=ENSOANG00000006119|UniProtKB=F6WTY3	Uncharacterized protein	ISS	2433589	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00021	FGF signaling pathway	P00645	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00059	p53 pathway	G01579	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	IDA	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00623	FGF	CHICK|Ensembl=ENSGALG00000007219|UniProtKB=Q9W6A1	Fibroblast growth factor	ISS	11376006	PubMed	PTHR11486:SF17	FIBROBLAST GROWTH FACTOR 12
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00053	T cell activation	P01319	PAK	CANLF|Ensembl=ENSCAFG00000004956|UniProtKB=E2REH3	Uncharacterized protein	ISS	14580336	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DANRE|ZFIN=ZDB-GENE-040625-35|UniProtKB=Q6IQL9	Novel actin protein	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	RAT|RGD=71083|UniProtKB=P30940	5-hydroxytryptamine receptor 1F	ISS	11701344	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00034	Integrin signalling pathway	P00924	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IPI	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MACMU|Gene=CHRM1|UniProtKB=P56489	Muscarinic acetylcholine receptor M1	TAS	10069496	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00029	Huntington disease	P00797	p53	RAT|RGD=1310332|UniProtKB=D4A8H8	Cytoplasmic FMR1 interacting protein 1 (Predicted)	ISS			PTHR12195:SF2	CYTOPLASMIC FMR1-INTERACTING PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	MONDO|Ensembl=ENSMODG00000018204|UniProtKB=F6PGX6	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_127490|UniProtKB=C3XYC5	Putative uncharacterized protein	IDA	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00056	VEGF signaling pathway	P01412	HSP27	DANRE|ZFIN=ZDB-GENE-020508-1|UniProtKB=Q8UUZ6	Alpha A crystallin	ISS			PTHR11527:SF36	ALPHA-CRYSTALLIN A CHAIN
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MACMU|Ensembl=ENSMMUG00000009341|UniProtKB=F6UA54	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00736	CalDAG-GEF	MOUSE|MGI=MGI=3028579|UniProtKB=Q6NZH9	Protein Rasgrp3	ISS	10835426	PubMed	PTHR23113:SF178	RAS GUANYL-RELEASING PROTEIN 3
P00009	Axon guidance mediated by netrin	P00363	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	TAS	12089061	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	DROME|FlyBase=FBgn0004573|UniProtKB=P20905	5-hydroxytryptamine receptor 1	IDA	12181435	PubMed	PTHR24247:SF171	5-HYDROXYTRYPTAMINE RECEPTOR 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00029	Huntington disease	G01529	Proline oxidase	MOUSE|MGI=MGI=1929093|UniProtKB=Q8VCZ9	Probable proline dehydrogenase 2	NAS			PTHR13914:SF5	PROLINE DEHYDROGENASE 2-RELATED
P00059	p53 pathway	G04694	p110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	BOVIN|Ensembl=ENSBTAG00000014447|UniProtKB=A4IFF4	Ribosomal protein S6 kinase	ISS	7688567	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P02747	Histidine biosynthesis	P02989	Phosphoribosyl AMP cyclohydrolase	BACSU|EnsemblGenome=BSU34860|UniProtKB=O34912	Histidine biosynthesis bifunctional protein HisIE	ISS			PTHR42945:SF1	HISTIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN HISIE, CHLOROPLASTIC
P00029	Huntington disease	P00811	Arp2/3 complex	RAT|RGD=2155|UniProtKB=O88656	Actin-related protein 2/3 complex subunit 1B	TAS	12473693	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00005	Angiogenesis	P00211	GSK3beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000005865|UniProtKB=G5E577	Uncharacterized protein	ISS	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MOUSE|MGI=MGI=2155600|UniProtKB=Q91Z83	Myosin-7	ISS	10938134	PubMed	PTHR13140:SF344	MYOSIN-7
P00010	B cell activation	P00381	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00780	Microtubule	MACMU|Ensembl=ENSMMUG00000023684|UniProtKB=P69895	Tubulin beta chain	ISS	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	MACMU|Ensembl=ENSMMUG00000018375|UniProtKB=F7H1D5	Neurogenic locus notch homolog protein 2 isoform 1 preproprotein	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00049	Parkinson disease	P01226	CDCrel-1	MACMU|Ensembl=ENSMMUG00000021842|UniProtKB=F7EIC6	Uncharacterized protein	ISS			PTHR18884:SF6	SEPTIN-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	XENTR|Xenbase=XB-GENE-1004371|UniProtKB=F6R882	Uncharacterized protein	ISS	12374786	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00030	Hypoxia response via HIF activation	P00819	AKT	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	TAS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00941	Integrin alpha	ANOGA|EnsemblGenome=AGAP006826|UniProtKB=Q7QIG1	AGAP006826-PA	IPI	3487386	PubMed	PTHR23220:SF83	INTEGRIN ALPHA-PS3-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CHICK|Ensembl=ENSGALG00000012894|UniProtKB=P30372	Muscarinic acetylcholine receptor M2	IDA	91373358	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01425	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DANRE|ZFIN=ZDB-GENE-000322-1|UniProtKB=Q9I8V1	Actin, alpha 1, skeletal muscle	IC	11889139	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	HUMAN|HGNC=4596|UniProtKB=Q14833	Metabotropic glutamate receptor 4	IC	12488551	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00056	VEGF signaling pathway	P01417	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DROME|FlyBase=FBgn0003093|UniProtKB=P13678	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	91072385	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	ORYSJ|EnsemblGenome=OS03G0780600|UniProtKB=P37832	Tubulin beta-7 chain	ISS	9454836	PubMed	PTHR11588:SF146	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	3755548	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00029	Huntington disease	P00786	ARF	DANRE|ZFIN=ZDB-GENE-030131-5234|UniProtKB=Q7ZUZ7	ADP-ribosylation factor 1	ISS	12932731	PubMed	PTHR11711:SF291	ADP-RIBOSYLATION FACTOR 1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	AQUAE|EnsemblGenome=aq_1505|UniProtKB=O67475	Ribonucleoside-diphosphate reductase subunit beta	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00021	FGF signaling pathway	P00629	PP2A	CANLF|Ensembl=ENSCAFG00000014257|UniProtKB=F1P8X1	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B	ISS	12191994	PubMed	PTHR11871:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B GAMMA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00047	PDGF signaling pathway	P01140	ELK	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	ISS	3183861	gi	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00048	PI3 kinase pathway	P01185	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00010	B cell activation	P00371	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04398	p53 pathway feedback loops 2	P04668	p53	ORNAN|Ensembl=ENSOANG00000013795|UniProtKB=F7DUR2	Uncharacterized protein (Fragment)	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	STRCO|Gene=CAB94611|UniProtKB=Q9K496	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00019	Endothelin signaling pathway	P00591	PLCbeta	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IGI	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	XENTR|Xenbase=XB-GENE-976753|UniProtKB=Q0VFR6	Syntaxin 1A (Brain)	ISS	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00056	VEGF signaling pathway	P01425	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000020947|UniProtKB=F7CY46	Uncharacterized protein	ISS	12441358	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P00034	Integrin signalling pathway	P00949	Shc	MOUSE|MGI=MGI=98296|UniProtKB=P98083	SHC-transforming protein 1	IPI	10982827	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00539	14-3-3	EMENI|EnsemblGenome=CADANIAG00005943|UniProtKB=Q5B4M9	1433_TRIHA 14-3-3 PROTEIN HOMOLOG (TH1433)	IGI	12023078	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	CANLF|Ensembl=ENSCAFG00000004381|UniProtKB=J9JH96	Uncharacterized protein	ISS	8314195	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00371	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00913	Csk	RAT|RGD=1308800|UniProtKB=P32577	Tyrosine-protein kinase CSK	IDA	12665526	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00046	Oxidative stress response	P01121	MKK3/6	MACMU|Ensembl=ENSMMUG00000010904|UniProtKB=F7GLY5	Uncharacterized protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00048	PI3 kinase pathway	P01185	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IGI	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	MACMU|Ensembl=ENSMMUG00000018375|UniProtKB=F7H1D5	Neurogenic locus notch homolog protein 2 isoform 1 preproprotein	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00012	Cadherin signaling pathway	P00470	F-actin	YARLI|EnsemblGenome=YALI0_D08272g|UniProtKB=Q9UVF3	Actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P02738	De novo purine biosynthesis	P02892	5-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase	SYNY3|EnsemblGenome=BAA18481|UniProtKB=P74384	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00012	Cadherin signaling pathway	P00475	Frizzled	BOVIN|Ensembl=ENSBTAG00000010529|UniProtKB=F1MP23	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF75	FRIZZLED-6
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	BOVIN|Ensembl=ENSBTAG00000019210|UniProtKB=F1MJV4	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00005	Angiogenesis	P00226	Delta/Serrate	CANLF|Ensembl=ENSCAFG00000005627|UniProtKB=E2QUR0	Delta-like protein	ISS	1286675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P02727	Androgen/estrogene/progesterone biosynthesis	P02829	Cholesterol acyltransferase	HUMAN|HGNC=11177|UniProtKB=P35610	Sterol O-acyltransferase 1	ISS	9756918	PubMed	PTHR10408:SF6	STEROL O-ACYLTRANSFERASE 1
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	MONDO|Ensembl=ENSMODG00000015696|UniProtKB=F7E0Q7	Fructose-bisphosphate aldolase	ISS	3391172	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	RAT|RGD=2348|UniProtKB=Q05941	Neuronal acetylcholine receptor subunit alpha-7	IC			PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IGI	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IGI	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00567	PKG	RAT|RGD=3401|UniProtKB=Q64595	cGMP-dependent protein kinase 2	IGI	12775716	PubMed	PTHR24353:SF24	SUBFAMILY NOT NAMED
P00012	Cadherin signaling pathway	P00470	F-actin	MONBE|Gene=37852|UniProtKB=A9V489	Predicted protein	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00034	Integrin signalling pathway	P00914	Filamin	MOUSE|MGI=MGI=95556|UniProtKB=Q8BTM8	Filamin-A	ISS	9722563	PubMed	PTHR43998:SF6	FILAMIN-A
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00049	Parkinson disease	P01211	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00566	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01211	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	DANRE|Ensembl=ENSDARG00000059090|UniProtKB=E7FDL0	Uncharacterized protein	ISS	12181435	PubMed	PTHR24229:SF75	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01154	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IDA	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04398	p53 pathway feedback loops 2	G04715	CYCLIN G	BOVIN|Ensembl=ENSBTAG00000006607|UniProtKB=Q5E9I1	Cyclin-G1	ISS	12556559	PubMed	PTHR10177:SF59	CYCLIN-G1
P00005	Angiogenesis	P00236	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06755	CBP	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	RCA	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00029	Huntington disease	P00807	Actin	XENTR|GeneID=394982|UniProtKB=P20399	Actin, alpha cardiac muscle 2	ISS	11889139	PubMed	PTHR11937:SF263	ACTIN
P02769	Purine metabolism	P03117	5'-AMP Deaminase	BOVIN|Ensembl=ENSBTAG00000015821|UniProtKB=E1BA23	Uncharacterized protein	ISS	1420359	PubMed	PTHR11359:SF2	AMP DEAMINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P02729	Ascorbate degradation	P02852	L-xylulose-5-phosphate-3-epimerase	ARATH|TAIR=AT5G61410|UniProtKB=Q9SAU2	D-ribulose-5-phosphate-3-epimerase	ISS			PTHR11749:SF4	D-RIBULOSE-5-PHOSPHATE-3-EPIMERASE
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	CANLF|Ensembl=ENSCAFG00000001315|UniProtKB=E2R9S7	Uncharacterized protein	ISS	10456847	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	HUMAN|HGNC=15906|UniProtKB=A7E2Y1	Myosin-7B	IEP	10938134	PubMed	PTHR13140:SF358	MYOSIN-7B
P00029	Huntington disease	P00795	BDNF	ORNAN|Ensembl=ENSOANG00000013030|UniProtKB=O02795	Brain-derived neurotrophic factor (Fragment)	ISS	11408619	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	RAT|RGD=2025|UniProtKB=P68136	Actin, alpha skeletal muscle	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00048	PI3 kinase pathway	P01177	P110ACT	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00828	Galphai	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	RCA			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00010	B cell activation	P00398	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00019	Endothelin signaling pathway	P00566	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00010	B cell activation	P00391	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	MOUSE|MGI=MGI=106684|UniProtKB=Q8R090	Chromaffin granule amine transporter	ISS	11443533	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	88241036	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04563	Ets	HUMAN|HGNC=3488|UniProtKB=P14921	Protein C-ets-1	IDA	9157999	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	PANTR|Ensembl=ENSPTRG00000021812|UniProtKB=H2R4R8	Uncharacterized protein	ISS	11430913	PubMed	PTHR23122:SF40	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00034	Integrin signalling pathway	P00917	ELMO	BOVIN|Ensembl=ENSBTAG00000003490|UniProtKB=F1MQH0	Uncharacterized protein	ISS	12879077	PubMed	PTHR12771:SF23	ENGULFMENT AND CELL MOTILITY PROTEIN 1
P00018	EGF receptor signaling pathway	P00561	STAT	CANLF|Ensembl=ENSCAFG00000015509|UniProtKB=F1PNW8	Signal transducer and activator of transcription	ISS	8732682	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	RAT|RGD=3187|UniProtKB=Q07008	Neurogenic locus notch homolog protein 1	IDA	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00036	Interleukin signaling pathway	P00990	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00029	Huntington disease	P00775	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	10802295	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04395	Vasopressin synthesis	P04596	Endo Peptidase	ECOLI|EcoGene=EG11004|UniProtKB=P24555	Protease 2	IC			PTHR11757:SF3	PROTEASE 2
P02787	Vitamin B6 metabolism	P03242	Threonine synthase	NEUCR|EnsemblGenome=EFNCRG00000002573|UniProtKB=Q1K5C3	Threonine synthase	ISS	18376360	gi	PTHR42690:SF1	THREONINE SYNTHASE-LIKE 2
P00008	Axon guidance mediated by Slit/Robo	P00347	Abl	RAT|RGD=1584969|UniProtKB=E9PT20	Tyrosine-protein kinase	ISS	8986783	PubMed	PTHR24418:SF88	TYROSINE-PROTEIN KINASE ABL1
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00060	Ubiquitin proteasome pathway	P01492	E1	HUMAN|HGNC=12469|UniProtKB=P22314	Ubiquitin-like modifier-activating enzyme 1	ISS			PTHR10953:SF155	UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 1
P02772	Pyruvate metabolism	P03137	Citrate Lyase	MYCTU|EnsemblGenome=Rv2498c|UniProtKB=P9WPE1	Citrate lyase subunit beta-like protein	ISS			PTHR32308:SF0	CITRATE LYASE SUBUNIT BETA
P00056	VEGF signaling pathway	P01411	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00021	FGF signaling pathway	P00634	MEKK1-5	RAT|RGD=1311192|UniProtKB=A0A0G2K3R1	Protein Map3k4	ISS	9079650	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00046	Oxidative stress response	P01129	JNK1/2	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01443	Phospholipase C	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P06664	Gonadotropin-releasing hormone receptor pathway	P06849	Sos	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	RCA	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	DROME|FlyBase=FBgn0001991|UniProtKB=Q24270	Voltage-dependent calcium channel type D subunit alpha-1	IC	15621031	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	RAT|RGD=2959|UniProtKB=P48550	G protein-activated inward rectifier potassium channel 2	ISS	12374786	PubMed	PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P00057	Wnt signaling pathway	P01443	Phospholipase C	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	8687401	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00019	Endothelin signaling pathway	P00572	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04395	Vasopressin synthesis	P04597	Signal Peptide	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00049	Parkinson disease	P01236	Casein kinase II	BOVIN|Gene=CSNK2A2|UniProtKB=P20427	Casein kinase II subunit alpha'	IDA	10806215	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00005	Angiogenesis	P00216	Caspase 9	PANTR|Ensembl=ENSPTRG00000000200|UniProtKB=H2PY35	Caspase	ISS	11440972	PubMed	PTHR10454:SF157	CASPASE-9
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	8170357	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00036	Interleukin signaling pathway	P00983	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05730	Endogenous cannabinoid signaling	P05751	Galpha	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00642	MEK1-2	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00005	Angiogenesis	P00243	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	HUMAN|HGNC=4581|UniProtKB=Q13003	Glutamate receptor ionotropic, kainate 3	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DANRE|ZFIN=ZDB-GENE-040426-2427|UniProtKB=F1Q6C0	Uncharacterized protein (Fragment)	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	BOVIN|Ensembl=ENSBTAG00000009245|UniProtKB=Q0P594	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	RAT|RGD=3693|UniProtKB=Q01818	Chromaffin granule amine transporter	ISS	11443533	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00029	Huntington disease	P00775	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	TRYB2|Gene=Tb11.v4.0005|UniProtKB=Q382Q2	Ribonucleoside-diphosphate reductase small chain	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	TAS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05913	Enkephalin release	P05972	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00010	B cell activation	P00375	Calmodulin	ORYSJ|EnsemblGenome=OS05G0491100|UniProtKB=Q6F332	Calmodulin-2	ISS	3885394	PubMed	PTHR23050:SF324	CALMODULIN-2-RELATED
P00010	B cell activation	P00379	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	IDA	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05730	Endogenous cannabinoid signaling	P05746	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00049	Parkinson disease	P01219	SAPK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00019	Endothelin signaling pathway	P00566	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04397	p53 pathway by glucose deprivation	P04639	AMPK	RAT|RGD=71057|UniProtKB=P80386	5'-AMP-activated protein kinase subunit beta-1	ISS			PTHR10343:SF16	5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1
P00059	p53 pathway	P04616	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=1309999|UniProtKB=Q922R0	cAMP-dependent protein kinase catalytic subunit PRKX	IC	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEEL|WormBase=WBGene00004033|UniProtKB=P90980	Protein kinase C-like 2	ISS	15572354	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IDA	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04393	Ras Pathway	P04570	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CANLF|Gene=GRIN1|UniProtKB=Q5R1P0	Glutamate receptor ionotropic, NMDA 1	IC	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	MONDO|Ensembl=ENSMODG00000012761|UniProtKB=F6SJA3	Tyrosine-protein kinase receptor (Fragment)	ISS	6754360	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05994	G-protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00049	Parkinson disease	P01238	14-3-3	RAT|RGD=62000|UniProtKB=P62260	14-3-3 protein epsilon	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IGI	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00589	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	RCA	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00054	Toll receptor signaling pathway	P01352	p38	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DICDI|dictyBase=DDB_G0279413|UniProtKB=P05987	cAMP-dependent protein kinase regulatory subunit	IC	176910	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00029	Huntington disease	G01530	HTT	MOUSE|MGI=MGI=96067|UniProtKB=P42859	Huntingtin	IDA	8268927	PubMed	PTHR10170:SF10	HUNTINGTIN
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00811	Arp2/3 complex	BOVIN|Ensembl=ENSBTAG00000046248|UniProtKB=Q58CQ2	Actin-related protein 2/3 complex subunit 1B	ISS	12963527	gi	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02746	Heme biosynthesis	P02979	porphobilinogen synthase	ECOLI|EcoGene=EG10428|UniProtKB=P0ACB2	Delta-aminolevulinic acid dehydratase	ISS			PTHR11458:SF0	DELTA-AMINOLEVULINIC ACID DEHYDRATASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MOUSE|MGI=MGI=1339712|UniProtKB=P13542	Myosin-8	IEP	10938134	PubMed	PTHR13140:SF368	MYOSIN-8
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	MOUSE|MGI=MGI=108224|UniProtKB=Q62401	C-C motif chemokine 12	ISS			PTHR12015:SF98	C-C MOTIF CHEMOKINE 2
P00021	FGF signaling pathway	P00644	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IGI	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01428	Frizzled	BOVIN|Ensembl=ENSBTAG00000020742|UniProtKB=F1MBL4	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF79	FRIZZLED-9
P00059	p53 pathway	P01486	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00054	Toll receptor signaling pathway	P01354	NFkappaB	CHICK|Ensembl=ENSGALG00000012304|UniProtKB=Q04861	Nuclear factor NF-kappa-B p105 subunit	ISS	12574369	PubMed	PTHR24169:SF9	NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT
P00006	Apoptosis signaling pathway	P00260	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00011	Blood coagulation	P00413	HMWK	RAT|RGD=2980|UniProtKB=P08934	Kininogen-1	ISS	6981138	gi	PTHR13814:SF12	KININOGEN-1
P00011	Blood coagulation	P00448	vWF	MACMU|Ensembl=ENSMMUG00000022893|UniProtKB=F6WF14	Uncharacterized protein	ISS	193400	OMIM	PTHR11339:SF361	VON WILLEBRAND FACTOR-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04674	Mdm2	MACMU|Ensembl=ENSMMUG00000014193|UniProtKB=F7AKR9	Uncharacterized protein	ISS	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05918	p38 MAPK pathway	P06031	p38alpha	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	RCA	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P02738	De novo purine biosynthesis	P02905	Amidophosphoribosyl transferase	MYCTU|EnsemblGenome=Rv0808|UniProtKB=P9WHQ7	Amidophosphoribosyltransferase	ISS			PTHR11907:SF0	AMIDOPHOSPHORIBOSYLTRANSFERASE
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	DAPPU|EnsemblGenome=DAPPUDRAFT_231787|UniProtKB=E9HKA6	Serine/threonine-protein phosphatase	ISS	10433257	PubMed	PTHR11668:SF402	SERINE/THREONINE-PROTEIN PHOSPHATASE
P02763	Peptidoglycan biosynthesis	P03090	N-Acetylglucosaminyl transferase	STRCO|Gene=CAC13078|UniProtKB=Q9EX00	Uncharacterized protein	ISS			PTHR43025:SF4	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	MACMU|Ensembl=ENSMMUG00000017143|UniProtKB=F7H113	Uncharacterized protein	ISS	11907044	PubMed	PTHR44025:SF5	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS	12874273	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	CHICK|Gene=CHRM4|UniProtKB=P17200	Muscarinic acetylcholine receptor M4	TAS	8100450	PubMed	PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02771	Pyrimidine Metabolism	P03130	Cytidine Deaminase	MACMU|Ensembl=ENSMMUG00000001498|UniProtKB=F7B5K3	Uncharacterized protein	ISS	12844405	PubMed	PTHR11644:SF2	CYTIDINE DEAMINASE
P04398	p53 pathway feedback loops 2	P04649	Myc	STRPU|EnsemblGenome=SPU_003166|UniProtKB=W4XIE2	Uncharacterized protein	TAS			PTHR11514:SF95	MYC PROTEIN
P00054	Toll receptor signaling pathway	P01375	JNK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00005	Angiogenesis	P00254	GTPase	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	ISS	12039949	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00029	Huntington disease	P00807	Actin	CAEBR|Gene=CBG23090|UniProtKB=A8Y4R0	Protein CBG23090	ISS	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00021	FGF signaling pathway	P00633	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04396	Vitamin D metabolism and pathway	P04602	RXR	MONDO|Ensembl=ENSMODG00000013112|UniProtKB=F7BMR6	Uncharacterized protein	ISS			PTHR24082:SF115	RETINOIC ACID RECEPTOR ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	RAT|RGD=1595475|UniProtKB=D4AAI1	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF26	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT GAMMA-T1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00006	Apoptosis signaling pathway	P00310	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01457	GBeta	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	11313908	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00052	TGF-beta signaling pathway	P01289	I-Smads	DROME|FlyBase=FBgn0020493|UniProtKB=Q5U110	Mothers against decapentaplegic homolog	IGI	http://flybase.org/reports/FBgn0020493.html	Website	PTHR13703:SF44	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=1351343|UniProtKB=Q5NCH9	Metabotropic glutamate receptor 6	ISS	11431030	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	IC	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00053	T cell activation	P01306	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00022	General transcription by RNA polymerase I	P00657	TBP	DICDI|dictyBase=DDB_G0275617|UniProtKB=P26355	TATA-box-binding protein	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02783	Tryptophan biosynthesis	P03206	Anthranilate synthase	STRCO|Gene=CAB38584|UniProtKB=Q9Z4W8	Probable anthranilate synthase component II	RCA			PTHR43418:SF4	MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00379	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00030	Hypoxia response via HIF activation	P00814	P300	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00052	TGF-beta signaling pathway	P01275	P38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	TAS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02750	Lipoate_biosynthesis	P03003	Lipoyl-protein ligase	DROME|FlyBase=FBgn0037251|UniProtKB=Q9VN27	Putative lipoyltransferase 2, mitochondrial	ISS			PTHR10993:SF7	LIPOYLTRANSFERASE 2, MITOCHONDRIAL-RELATED
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	BOVIN|Ensembl=ENSBTAG00000011723|UniProtKB=E1BKL6	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00023	General transcription regulation	P00658	TBP-associated factors	SCHPO|PomBase=SPCC1259.06|UniProtKB=O94706	Transcription initiation factor TFIID subunit 8	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000008826|UniProtKB=F6XUU0	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00046	Oxidative stress response	P01134	cPLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	PANTR|Ensembl=ENSPTRG00000003795|UniProtKB=H2Q3X5	Muscarinic acetylcholine receptor	ISS	11166329	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	MOUSE|MGI=MGI=1339984|UniProtKB=Q8CIN4	Serine/threonine-protein kinase PAK 2	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00006	Apoptosis signaling pathway	P00269	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000014807|UniProtKB=F6W548	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00059	p53 pathway	P01485	p53	DANRE|ZFIN=ZDB-GENE-990415-270|UniProtKB=P79734	Cellular tumor antigen p53	TAS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00036	Interleukin signaling pathway	P00980	IRS1/2	MACMU|Ensembl=ENSMMUG00000019467|UniProtKB=F6SUL3	Uncharacterized protein	ISS	1311924	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00054	Toll receptor signaling pathway	P01352	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	8170357	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00021	FGF signaling pathway	P00640	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00539	14-3-3	ORYSJ|EnsemblGenome=OS04G0462500|UniProtKB=Q7XTE8	14-3-3-like protein GF14-B	ISS	10407019	PubMed	PTHR18860:SF36	SUBFAMILY NOT NAMED
P00017	DNA replication	P00535	5' to 3' Exoribonulcease	HUMAN|HGNC=12836|UniProtKB=Q9H0D6	5'-3' exoribonuclease 2	ISS	7885830	PubMed	PTHR12341:SF41	5'-3' EXORIBONUCLEASE 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CHICK|Ensembl=ENSGALG00000001172|UniProtKB=P19439	Probable glutamate receptor	IC	12871085	PubMed	PTHR18966:SF282	GLUTAMATE RECEPTOR-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	MACMU|Ensembl=ENSMMUG00000021442|UniProtKB=F7EAQ8	Muscarinic acetylcholine receptor	ISS	11166329	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	IC	91056091	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00048	PI3 kinase pathway	P01192	p110	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	MYCTU|EnsemblGenome=Rv3667|UniProtKB=P9WQD1	Acetyl-coenzyme A synthetase	ISS			PTHR24095:SF14	ACETYL-COENZYME A SYNTHETASE 1
P00010	B cell activation	P00381	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_79607|UniProtKB=C3ZHN4	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00029	Huntington disease	P00807	Actin	CAEBR|Gene=CBG02167|UniProtKB=A8WS37	Protein CBG02167	ISS	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00586	Gq	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00019	Endothelin signaling pathway	P00587	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01438	PP2A	PANTR|Ensembl=ENSPTRG00000018180|UniProtKB=H2QT14	Protein phosphatase 2, regulatory subunit B', delta	ISS	12110603	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00010	B cell activation	P00391	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00193	SOS-1	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	RAT|RGD=619877|UniProtKB=P19804	Nucleoside diphosphate kinase B	ISS			PTHR11349:SF57	NUCLEOSIDE DIPHOSPHATE KINASE B
P00018	EGF receptor signaling pathway	P00550	Grb2	CAEBR|Gene=CBG16856|UniProtKB=A8XPY6	Protein CBR-SEM-5	ISS	4504111	gi	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	XENTR|Xenbase=XB-GENE-1005779|UniProtKB=F7E3I6	Uncharacterized protein	ISS	11248120	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00748	Gbeta5L	PANTR|Ensembl=ENSPTRG00000007084|UniProtKB=H2Q9G5	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00021	FGF signaling pathway	P00648	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IGI	3045562	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00034	Integrin signalling pathway	P00923	Arf1	MOUSE|MGI=MGI=99431|UniProtKB=P84078	ADP-ribosylation factor 1	ISS	12932731	PubMed	PTHR11711:SF234	ADP-RIBOSYLATION FACTOR 1
P05731	GABA-B receptor II signaling	P05755	Gbeta	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00010	B cell activation	P00386	Calcineurin	BOVIN|Ensembl=ENSBTAG00000016005|UniProtKB=P48452	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	IDA	7532676	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	8838318	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P04393	Ras Pathway	P04574	PLD	MACMU|Ensembl=ENSMMUG00000005666|UniProtKB=F6VWY6	Uncharacterized protein	ISS	9538008	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IGI	9514948	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00037	Ionotropic glutamate receptor pathway	P01026	KA	CHICK|Ensembl=ENSGALG00000015434|UniProtKB=F1NU20	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	IDA	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00057	Wnt signaling pathway	P01446	Calcineurin	CHICK|Ensembl=ENSGALG00000005243|UniProtKB=E1C2T7	Serine/threonine-protein phosphatase	ISS	12015605	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P05731	GABA-B receptor II signaling	P05752	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	CAEEL|WormBase=WBGene00000201|UniProtKB=Q9U1R7	ARp2/3 compleX component	ISS	12963527	gi	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P02742	Tetrahydrofolate biosynthesis	P02951	GTP cyclohydrolase	PANTR|Ensembl=ENSPTRG00000006365|UniProtKB=H2RBI2	GTP cyclohydrolase 1	ISS			PTHR11109:SF0	GTP CYCLOHYDROLASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00052	TGF-beta signaling pathway	P01284	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P06664	Gonadotropin-releasing hormone receptor pathway	P06836	PG Rcs	MOUSE|MGI=MGI=97794|UniProtKB=Q62053	Prostaglandin E2 receptor EP2 subtype	RCA			PTHR11866:SF8	PROSTAGLANDIN E2 RECEPTOR EP2 SUBTYPE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	CHICK|Ensembl=ENSGALG00000028102|UniProtKB=F1P3X4	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF657	MYOSIN-4
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P06001	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	DANRE|ZFIN=ZDB-GENE-010125-1|UniProtKB=B8JHS2	Uncharacterized protein	IDA	11259498	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00010	B cell activation	P00402	Jnk	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P02738	De novo purine biosynthesis	P02902	ADP reductase	TRYB2|Gene=Tb11.02.5720|UniProtKB=Q384N4	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00049	Parkinson disease	P01208	Hsp70	ANOGA|EnsemblGenome=AGAP010876|UniProtKB=Q7PFH8	AGAP010876-PA (Fragment)	IDA	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P00018	EGF receptor signaling pathway	P00549	EGF	BOVIN|Ensembl=ENSBTAG00000021766|UniProtKB=E1BIN8	Uncharacterized protein	ISS	8488984	gi	PTHR10740:SF4	PROHEPARIN-BINDING EGF-LIKE GROWTH FACTOR
P00019	Endothelin signaling pathway	P00591	PLCbeta	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00030	Hypoxia response via HIF activation	P00814	P300	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00046	Oxidative stress response	P01124	Myc	DANRE|ZFIN=ZDB-GENE-980526-499|UniProtKB=Q6P943	Signal transducer and activator of transcription	IC			PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BOVIN|Ensembl=ENSBTAG00000006495|UniProtKB=P11017	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	DANRE|ZFIN=ZDB-GENE-030102-4|UniProtKB=Q8AV68	Cholinergic receptor, nicotinic, beta polypeptide 3b	ISS			PTHR18945:SF75	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-3
P00052	TGF-beta signaling pathway	P01284	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02783	Tryptophan biosynthesis	P03209	Anthranilate phosphoribosyl transferase	YEAST|SGD=S000001694|UniProtKB=P00937	Multifunctional tryptophan biosynthesis protein	ISS			PTHR43418:SF4	MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00036	Interleukin signaling pathway	P00965	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01219	SAPK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00022	General transcription by RNA polymerase I	P00657	TBP	MOUSE|MGI=MGI=1339946|UniProtKB=P62340	TATA box-binding protein-like protein 1	ISS	600075	OMIM	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00019	Endothelin signaling pathway	P00591	PLCbeta	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00006	Apoptosis signaling pathway	P00260	AKT	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	20855874	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	DROME|FlyBase=FBgn0263111|UniProtKB=P91645	Voltage-dependent calcium channel type A subunit alpha-1	ISS	14507926	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P00059	p53 pathway	P04630	PP2A	MONDO|Ensembl=ENSMODG00000019001|UniProtKB=F7CP86	Serine/threonine-protein phosphatase	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05925	beta-ARR1	MOUSE|MGI=MGI=99473|UniProtKB=Q8BWG8	Beta-arrestin-1	RCA	9388255	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P02738	De novo purine biosynthesis	P02909	GDP reductase	MYCTU|EnsemblGenome=Rv0570|UniProtKB=P9WH77	Vitamin B12-dependent ribonucleoside-diphosphate reductase	ISS			PTHR43371:SF1	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00030	Hypoxia response via HIF activation	P00819	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00997	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	10982827	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00008	Axon guidance mediated by Slit/Robo	P00355	Rho	BOVIN|Ensembl=ENSBTAG00000014299|UniProtKB=Q1RMJ6	Rho-related GTP-binding protein RhoC	ISS	12090470	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05915	Opioid proenkephalin pathway	P05989	leu-Enkephalin	XENTR|Xenbase=XB-GENE-942760|UniProtKB=F6Y5F6	Uncharacterized protein	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00034	Integrin signalling pathway	P00936	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00021	FGF signaling pathway	P00624	14-3-3	BOVIN|Gene=YWHAB|UniProtKB=P68250	14-3-3 protein beta/alpha	IDA	1671102	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P06212	DPP-SCW signaling pathway	P06274	SAX	DROME|Gene=Dmel_CG1891|UniProtKB=A0A0B4K7J3	Receptor protein serine/threonine kinase	IDA	9395284	PubMed	PTHR23255:SF72	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00034	Integrin signalling pathway	P00951	Jnk	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DROME|FlyBase=FBgn0000045|UniProtKB=P02574	Actin, larval muscle	IC	14684598	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	BOVIN|Gene=SLC18A2|UniProtKB=Q27963	Synaptic vesicular amine transporter	ISS	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P05912	Dopamine receptor mediated signaling pathway	P05963	MAO	HUMAN|HGNC=6833|UniProtKB=P21397	Amine oxidase [flavin-containing] A	ISS	90344230	PubMed	PTHR43563:SF3	AMINE OXIDASE  FLAVIN-CONTAINING  A
P00034	Integrin signalling pathway	P00941	Integrin alpha	MACMU|Ensembl=ENSMMUG00000019462|UniProtKB=F7FY86	Uncharacterized protein	ISS	3487386	PubMed	PTHR23220:SF4	INTEGRIN ALPHA-V
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	PANTR|Ensembl=ENSPTRG00000015241|UniProtKB=Q5IS72	D(3) dopamine receptor	ISS	11248120	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00005	Angiogenesis	P00213	FGF	ORNAN|Ensembl=ENSOANG00000014242|UniProtKB=F6WG78	Fibroblast growth factor	ISS	12057924	PubMed	PTHR11486:SF86	FIBROBLAST GROWTH FACTOR 1
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=12789|UniProtKB=Q93098	Protein Wnt-8b	IDA	11266476	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P04393	Ras Pathway	P04550	Ral	MOUSE|MGI=MGI=1927244|UniProtKB=Q9JIW9	Ras-related protein Ral-B	ISS	10328920	PubMed	PTHR24070:SF199	RAS-RELATED PROTEIN RAL-B
P05913	Enkephalin release	P05972	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00514	MLCK	HUMAN|HGNC=7590|UniProtKB=Q15746	Myosin light chain kinase, smooth muscle	TAS	600922	OMIM	PTHR45480:SF1	MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00017	DNA replication	P00527	Histones	DROME|FlyBase=FBgn0001199|UniProtKB=P02299	Histone H3	ISS	12413958	PubMed	PTHR11426:SF20	HISTONE H3-LIKE CENTROMERIC PROTEIN A
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	HUMAN|HGNC=11640|UniProtKB=Q9HCS4	Transcription factor 7-like 1	IEP	11266476	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00049	Parkinson disease	P01237	Complex I	ANOGA|EnsemblGenome=AGAP002170|UniProtKB=Q7QK64	AGAP002170-PA	TAS	3100899	PubMed	PTHR10371:SF3	NADH DEHYDROGENASE  UBIQUINONE  FLAVOPROTEIN 2, MITOCHONDRIAL
P00034	Integrin signalling pathway	P00916	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P00021	FGF signaling pathway	P00623	FGF	MACMU|Ensembl=ENSMMUG00000009842|UniProtKB=F7A1B0	Fibroblast growth factor	ISS			PTHR11486:SF20	FIBROBLAST GROWTH FACTOR 7
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00633	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01285	TAK	MACMU|Ensembl=ENSMMUG00000003024|UniProtKB=F6VN73	Uncharacterized protein	ISS	10683140	PubMed	PTHR26392:SF77	EXTRACELLULAR TYROSINE-PROTEIN KINASE PKDCC
P00034	Integrin signalling pathway	P00925	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00059	p53 pathway	G04694	p110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00018	EGF receptor signaling pathway	P00550	Grb2	DANRE|ZFIN=ZDB-GENE-040426-1975|UniProtKB=Q6PC73	Growth factor receptor-bound protein 2	ISS	8479536	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DICDI|dictyBase=DDB_G0289487|UniProtKB=P07829	Actin-3	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IDA	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00059	p53 pathway	P04616	PDK1/2	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	RAT|RGD=3251|UniProtKB=Q62829	Serine/threonine-protein kinase PAK 3	ISS	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00053	T cell activation	P01330	IKK	MACMU|Ensembl=ENSMMUG00000008351|UniProtKB=F7HRV5	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00007	Axon guidance mediated by semaphorins	P00337	Sema3A	BOVIN|Ensembl=ENSBTAG00000018133|UniProtKB=F1MEW1	Uncharacterized protein	ISS	7748562	PubMed	PTHR11036:SF23	SEMAPHORIN-3A
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04396	Vitamin D metabolism and pathway	P04603	1alpha-Hydroxylase	RAT|RGD=727915|UniProtKB=P17178	Sterol 26-hydroxylase, mitochondrial	IDA	11013342	PubMed	PTHR24291:SF6	STEROL 26-HYDROXYLASE, MITOCHONDRIAL
P00034	Integrin signalling pathway	P00911	B-Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	ISS	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	PANTR|Ensembl=ENSPTRG00000024064|UniProtKB=H2R3R2	Synaptotagmin I	ISS	1589771	PubMed	PTHR10024:SF239	SYNAPTOTAGMIN-1
P05731	GABA-B receptor II signaling	P05754	Ggamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	RCA	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00549	EGF	MOUSE|MGI=MGI=96070|UniProtKB=Q06186	Proheparin-binding EGF-like growth factor	ISS	12746188	PubMed	PTHR10740:SF4	PROHEPARIN-BINDING EGF-LIKE GROWTH FACTOR
P00018	EGF receptor signaling pathway	P00546	GAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	8262392	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00010	B cell activation	P00402	Jnk	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IDA	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00521	Profilin	MOUSE|MGI=MGI=97550|UniProtKB=Q9JJV2	Profilin-2	ISS			PTHR13936:SF15	PROFILIN-2
P04398	p53 pathway feedback loops 2	P04665	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=98962|UniProtKB=P28047	Protein Wnt-7b	IDA	8717036	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00010	B cell activation	P00383	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	CAEEL|WormBase=WBGene00000903|UniProtKB=P92172	Dauer larva development regulatory growth factor daf-7	TAS	9759503	PubMed	PTHR11848:SF176	LD29161P
P00034	Integrin signalling pathway	P00907	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04547	Ras	DANRE|ZFIN=ZDB-GENE-040808-67|UniProtKB=Q6AZA4	K-ras	ISS	20362513	PubMed	PTHR24070:SF186	GTPASE KRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	CANLF|Ensembl=ENSCAFG00000005204|UniProtKB=B6V8E6	Catenin beta-1	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P00048	PI3 kinase pathway	P01177	P110ACT	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00631	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MACMU|Ensembl=ENSMMUG00000001661|UniProtKB=F7GR69	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	DROME|FlyBase=FBgn0032003|UniProtKB=Q7KTJ2	CG8349	ISS			PTHR11644:SF2	CYTIDINE DEAMINASE
P02779	Thiamin biosynthesis	P03170	Hydroxymethylpyrimidine phosphate kinase	METAC|EnsemblGenome=MA_3197|UniProtKB=Q8TL45	Phosphomethylpyrimidine kinase	ISS			PTHR20858:SF17	HYDROXYMETHYLPYRIMIDINE/PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED
P00049	Parkinson disease	P01238	14-3-3	BOVIN|Ensembl=ENSBTAG00000005664|UniProtKB=P62261	14-3-3 protein epsilon	ISS	9450960	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00052	TGF-beta signaling pathway	P01275	P38	DROME|FlyBase=FBgn0024846|UniProtKB=O61443	Mitogen-activated protein kinase 14B	TAS	11707292	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	BOVIN|Ensembl=ENSBTAG00000034854|UniProtKB=F1N246	Uncharacterized protein	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00023	General transcription regulation	P00663	TFIIFalpha	HUMAN|HGNC=4652|UniProtKB=P35269	General transcription factor IIF subunit 1	ISS	12732728	PubMed	PTHR13011:SF0	GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1
P00036	Interleukin signaling pathway	P00972	MNK1/2	XENTR|Xenbase=XB-GENE-979969|UniProtKB=Q66JF3	MAP kinase-interacting serine/threonine-protein kinase 1	ISS			PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	HUMAN|HGNC=235|UniProtKB=Q8NFM4	Adenylate cyclase type 4	ISS	1946437	PubMed	PTHR11920:SF286	ADENYLATE CYCLASE TYPE 4
P02762	Pentose phosphate pathway	P03070	Gluconate Dehydrogenase	CHICK|Ensembl=ENSGALG00000002797|UniProtKB=Q5ZIZ0	6-phosphogluconate dehydrogenase, decarboxylating	ISS	8978909	PubMed	PTHR11811:SF25	6-PHOSPHOGLUCONATE DEHYDROGENASE, DECARBOXYLATING
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05918	p38 MAPK pathway	P06044	GADD45	MOUSE|MGI=MGI=107799|UniProtKB=P48316	Growth arrest and DNA damage-inducible protein GADD45 alpha	RCA	7509226	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00005	Angiogenesis	P00243	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	3449797	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00029	Huntington disease	P00805	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IDA	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06782	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	RCA	91298951	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00628	JNK1-3	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02785	Valine biosynthesis	P03216	Acetolactate synthase	DEIRA|EnsemblGenome=DR_1516|UniProtKB=Q9RU76	Acetolactate synthase	ISS			PTHR18968:SF116	ACETOLACTATE SYNTHASE ISOZYME 3 LARGE SUBUNIT
P00045	Notch signaling pathway	P01109	Aph-1	HUMAN|HGNC=29509|UniProtKB=Q96BI3	Gamma-secretase subunit APH-1A	IC			PTHR12889:SF3	GAMMA-SECRETASE SUBUNIT APH-1A
P00059	p53 pathway	G04694	p110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000003364|UniProtKB=F6ZPQ4	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00049	Parkinson disease	P01211	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	9603989	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01234	GRK	BOVIN|Gene=ADRBK2|UniProtKB=P26818	Beta-adrenergic receptor kinase 2	IDA	10852916	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P00018	EGF receptor signaling pathway	P00551	Akt	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	IGI	7876156	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00051	TCA cycle	P01268	Aconitase	ECOLI|EcoGene=EG13666|UniProtKB=P75764	Uncharacterized protein YbhJ	RCA			PTHR43160:SF3	ACONITATE HYDRATASE, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00627	ERK1-2	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04572	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	P01444	Wnt	CAEEL|WormBase=WBGene00000858|UniProtKB=P34889	Protein Wnt-2	IDA	8717036	PubMed	PTHR12027:SF77	PROTEIN WNT-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	DANRE|ZFIN=ZDB-GENE-060824-1|UniProtKB=C3PTE8	Beta-arrestin 1	ISS	11742073	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ORYSJ|EnsemblGenome=OS03G0836000|UniProtKB=Q10AZ4	Actin-3	ISS	14684598	PubMed	PTHR11937:SF254	ACTIN-1-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	MOUSE|MGI=MGI=88296|UniProtKB=O55017	Voltage-dependent N-type calcium channel subunit alpha-1B	IDA	14507926	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00018	EGF receptor signaling pathway	P00563	Gab	MOUSE|MGI=MGI=1333854|UniProtKB=Q9Z1S8	GRB2-associated-binding protein 2	IGI	15356145	PubMed	PTHR12156:SF4	GRB2-ASSOCIATED-BINDING PROTEIN 2
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT1G10210|UniProtKB=Q39021	Mitogen-activated protein kinase 1	ISS	94177172	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P04393	Ras Pathway	P04558	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00565	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	PLAF7|EnsemblGenome=PF10_0322|UniProtKB=Q8IJ77	S-adenosylmethionine decarboxylase-ornithine decarboxylase	ISS			PTHR11482:SF6	ORNITHINE DECARBOXYLASE 1-RELATED
P00021	FGF signaling pathway	P00633	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00048	PI3 kinase pathway	P01200	SHIP	PANTR|Ensembl=ENSPTRG00000004031|UniProtKB=H2Q4C6	Inositol polyphosphate phosphatase-like 1	ISS	10381377	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00047	PDGF signaling pathway	P01173	STAT	MACMU|Ensembl=ENSMMUG00000010707|UniProtKB=F7G8G5	Signal transducer and activator of transcription	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00005	Angiogenesis	P00226	Delta/Serrate	CANLF|Ensembl=ENSCAFG00000004094|UniProtKB=F1PNN6	Delta-like protein	ISS			PTHR24044:SF380	DELTA-LIKE PROTEIN 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00014	Cholesterol biosynthesis	P00492	Mevalonate kinase	MACMU|Ensembl=ENSMMUG00000011663|UniProtKB=F7HGV8	Uncharacterized protein	ISS	4557769	gi	PTHR43290:SF2	MEVALONATE KINASE
P00018	EGF receptor signaling pathway	P00547	PP2A	TRIAD|EnsemblGenome=TriadG63380|UniProtKB=B3S653	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00057	Wnt signaling pathway	P01440	Cadherin	XENTR|Xenbase=XB-GENE-980876|UniProtKB=F7BUJ8	Uncharacterized protein	ISS	8120095	PubMed	PTHR43912:SF5	PROTOCADHERIN-9
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00015	Circadian clock system	G01501	cry	RAT|RGD=735083|UniProtKB=Q32Q86	Cryptochrome-1	ISS	14507900	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DICDI|dictyBase=DDB_G0289811|UniProtKB=Q54GX7	Actin-10	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00047	PDGF signaling pathway	P01173	STAT	MACMU|Ensembl=ENSMMUG00000010707|UniProtKB=F7G8G5	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00036	Interleukin signaling pathway	P00964	p90RSK	PANTR|Ensembl=ENSPTRG00000000387|UniProtKB=H2PYE3	Ribosomal protein S6 kinase	ISS	7688567	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P02772	Pyruvate metabolism	P03136	Malic enzyme	PANTR|Ensembl=ENSPTRG00000018381|UniProtKB=H2QTC2	Malic enzyme	ISS	9954437	gi	PTHR23406:SF17	NADP-DEPENDENT MALIC ENZYME
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00019	Endothelin signaling pathway	P00591	PLCbeta	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00044	Nicotinic acetylcholine receptor signaling pathway	P01089	VAChT	SCHPO|PomBase=SPCC18.02|UniProtKB=O74852	Uncharacterized MFS-type transporter C18.02	IC	21863848	PubMed	PTHR23506:SF25	SUBFAMILY NOT NAMED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00006	Apoptosis signaling pathway	P00302	ATF	BOVIN|Ensembl=ENSBTAG00000008545|UniProtKB=Q2KII1	Cyclic AMP-dependent transcription factor ATF-3	ISS	11390664	PubMed	PTHR23351:SF23	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-3
P00034	Integrin signalling pathway	P00944	Actin	TAKRU|Ensembl=ENSTRUG00000005447|UniProtKB=P68142	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF354	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00807	Actin	HUMAN|HGNC=17780|UniProtKB=Q562R1	Beta-actin-like protein 2	IDA	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00012	Cadherin signaling pathway	P00470	F-actin	ASHGO|EnsemblGenome=AGOS_ABR222W|UniProtKB=Q75D00	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	MOUSE|MGI=MGI=96828|UniProtKB=Q91ZX7	Prolow-density lipoprotein receptor-related protein 1	IDA	11907044	PubMed	PTHR44025:SF2	PROLOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IDA	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04558	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	IDA	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00046	Oxidative stress response	P01129	JNK1/2	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00036	Interleukin signaling pathway	P00968	Ikk	HUMAN|HGNC=5960|UniProtKB=O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	IC	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	STRCO|EnsemblGenome=CAB61586|UniProtKB=Q9RJZ6	Probable aldehyde dehydrogenase	IC			PTHR43111:SF1	ALDEHYDE DEHYDROGENASE B
P00029	Huntington disease	P00775	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	CANLF|Ensembl=ENSCAFG00000015081|UniProtKB=E2RMT4	Uncharacterized protein	ISS	12963527	gi	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04397	p53 pathway by glucose deprivation	P04641	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00025	Hedgehog signaling pathway	P00689	Patched	MACMU|Ensembl=ENSMMUG00000002634|UniProtKB=F7H772	Uncharacterized protein	ISS	8647801	PubMed	PTHR10796:SF61	PROTEIN PATCHED HOMOLOG 1
P00034	Integrin signalling pathway	P00914	Filamin	MACMU|Ensembl=ENSMMUG00000013668|UniProtKB=F7GCM2	Uncharacterized protein	ISS	11911837	PubMed	PTHR43998:SF6	FILAMIN-A
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	MACMU|Ensembl=ENSMMUG00000010678|UniProtKB=F7AXI7	Uncharacterized protein	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	HUMAN|HGNC=1388|UniProtKB=O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	14624853	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00047	PDGF signaling pathway	P01162	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00752	cGMP-gated ion channel	PANTR|Ensembl=ENSPTRG00000012265|UniProtKB=H2QIE4	Uncharacterized protein	ISS	12432397	PubMed	PTHR10217:SF390	CYCLIC NUCLEOTIDE-GATED CATION CHANNEL ALPHA-3
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04393	Ras Pathway	P04553	PAK	BOVIN|Ensembl=ENSBTAG00000010191|UniProtKB=Q08E52	Serine/threonine-protein kinase PAK 1	ISS	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00012	Cadherin signaling pathway	P00471	Cadherin	MONDO|Ensembl=ENSMODG00000006996|UniProtKB=F6XVG8	Uncharacterized protein (Fragment)	ISS	8120095	PubMed	PTHR24027:SF85	CADHERIN-11
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00948	Rho	HUMAN|HGNC=667|UniProtKB=P61586	Transforming protein RhoA	ISS	12169092	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00056	VEGF signaling pathway	P01423	p38MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00568	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	IGI	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00021	FGF signaling pathway	P00641	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	MACMU|Ensembl=ENSMMUG00000015925|UniProtKB=F7AL30	Protein-serine/threonine kinase	RCA			PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00023	General transcription regulation	P00661	TTF2	MOUSE|MGI=MGI=105044|UniProtKB=Q62187	Transcription termination factor 1	IGI			PTHR10641:SF939	TRANSCRIPTION TERMINATION FACTOR 1
P04398	p53 pathway feedback loops 2	P04650	WIP-1	RAT|RGD=1305460|UniProtKB=B1WCA0	Ppm1d protein	ISS			PTHR13832:SF359	PROTEIN PHOSPHATASE 1D
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	MOUSE|MGI=MGI=104872|UniProtKB=P63087	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	ISS	8392016	PubMed	PTHR11668:SF204	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-GAMMA CATALYTIC SUBUNIT
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05731	GABA-B receptor II signaling	P05760	AC	MOUSE|MGI=MGI=99673|UniProtKB=P84309	Adenylate cyclase type 5	ISS	2491850	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00025	Hedgehog signaling pathway	P00683	Slimb	CANLF|Ensembl=ENSCAFG00000009879|UniProtKB=E2RDC4	Uncharacterized protein	ISS	10074433	PubMed	PTHR44038:SF2	F-BOX/WD REPEAT-CONTAINING PROTEIN 1A
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	XENTR|Xenbase=XB-GENE-957248|UniProtKB=Q6GLE6	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01153	GSK3	ARATH|TAIR=AT3G05840|UniProtKB=P43289	Shaggy-related protein kinase gamma	ISS	21361340	gi	PTHR24057:SF13	SHAGGY-RELATED PROTEIN KINASE ALPHA-RELATED
P05913	Enkephalin release	P05977	G-Protein (s)	DROME|FlyBase=FBgn0001105|UniProtKB=P26308	Guanine nucleotide-binding protein subunit beta-1	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00052	TGF-beta signaling pathway	P01284	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00005	Angiogenesis	P00237	FRP	BOVIN|Ensembl=ENSBTAG00000010977|UniProtKB=Q95117	Secreted frizzled-related protein 3	ISS	9118218	PubMed	PTHR11309:SF97	SECRETED FRIZZLED-RELATED PROTEIN 3
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=2157782|UniProtKB=Q8VHP6	Cadherin-related family member 1	IDA	8120095	PubMed	PTHR44506:SF1	CADHERIN-RELATED FAMILY MEMBER 1
P00060	Ubiquitin proteasome pathway	P01491	E2	MONDO|Ensembl=ENSMODG00000023075|UniProtKB=F7G1G8	Uncharacterized protein	ISS			PTHR43902:SF2	UBIQUITIN-CONJUGATING ENZYME E2 N
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=1197020|UniProtKB=O35468	Protein Wnt-9b	IDA	11266476	PubMed	PTHR12027:SF84	PROTEIN WNT-9B
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	IDA	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CHICK|Ensembl=ENSGALG00000004735|UniProtKB=F1NHE1	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02783	Tryptophan biosynthesis	P03206	Anthranilate synthase	AQUAE|EnsemblGenome=aq_549|UniProtKB=O66825	Anthranilate synthase component II	RCA			PTHR43418:SF4	MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	YEAST|SGD=S000002910|UniProtKB=P19358	S-adenosylmethionine synthase 2	ISS			PTHR11964:SF1	S-ADENOSYLMETHIONINE SYNTHASE
P00057	Wnt signaling pathway	P01446	Calcineurin	DICDI|dictyBase=DDB_G0276883|UniProtKB=Q7YSW8	Calcineurin subunit A	IDA	12015605	PubMed	PTHR11668:SF118	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED
P00034	Integrin signalling pathway	P00912	Arp2/3	DROME|FlyBase=FBgn0065032|UniProtKB=Q9VX82	Actin-related protein 2/3 complex subunit 3	IPI	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06703	IGF-1R	MOUSE|MGI=MGI=96433|UniProtKB=Q60751	Insulin-like growth factor 1 receptor	RCA	11182407	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00023	General transcription regulation	P00668	TFIIB	HALSA|EnsemblGenome=VNG_0734G|UniProtKB=Q9HRE6	Transcription initiation factor IIB 2	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00034	Integrin signalling pathway	P00924	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MOUSE|MGI=MGI=1338820|UniProtKB=Q9R229	Bone morphogenetic protein 10	TAS	9759503	PubMed	PTHR11848:SF39	BONE MORPHOGENETIC PROTEIN 10
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05918	p38 MAPK pathway	P06027	CREB	XENTR|Xenbase=XB-GENE-945015|UniProtKB=F6QA46	Uncharacterized protein	ISS	1354612	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00892	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	8262390	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00899	IRS 1-4	MACMU|Ensembl=ENSMMUG00000019467|UniProtKB=F6SUL3	Uncharacterized protein	ISS	15110093	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00023	General transcription regulation	P00658	TBP-associated factors	ANOGA|EnsemblGenome=AGAP003094|UniProtKB=Q7QBM3	AGAP003094-PA	ISS			PTHR12595:SF6	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 9
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MOUSE|MGI=MGI=2661081|UniProtKB=Q8K348	Activin receptor type-1C	ISS	9395284	PubMed	PTHR23255:SF58	ACTIVIN RECEPTOR TYPE-1C
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00008	Axon guidance mediated by Slit/Robo	P00344	Netrin	PANTR|Ensembl=ENSPTRG00000008752|UniProtKB=H2QC90	Uncharacterized protein	ISS	9427245	PubMed	PTHR10574:SF365	NETRIN-1
P00012	Cadherin signaling pathway	P00462	Casein kinase II	DANRE|ZFIN=ZDB-GENE-990415-29|UniProtKB=Q91398	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	CANLF|Ensembl=ENSCAFG00000017179|UniProtKB=J9P4A0	Uncharacterized protein	ISS	10487978	PubMed	PTHR10749:SF4	PHOSPHORYLASE B KINASE REGULATORY SUBUNIT ALPHA, SKELETAL MUSCLE ISOFORM
P00047	PDGF signaling pathway	P01173	STAT	MONDO|Ensembl=ENSMODG00000014816|UniProtKB=F7CHH2	Signal transducer and activator of transcription	ISS	10835485	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	CAEEL|WormBase=WBGene00002173|UniProtKB=Q9Y0A1	Inositol 1,4,5-trisphosphate receptor itr-1	IDA	12880387	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00006	Apoptosis signaling pathway	P00274	JNK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	ISS	12040174	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00009	Axon guidance mediated by netrin	P00364	cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00004	Alzheimer disease-presenilin pathway	P00113	Erb-B4 transmembrane fragment	MONDO|Ensembl=ENSMODG00000015755|UniProtKB=F6ZSZ9	Uncharacterized protein (Fragment)	ISS	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00010	B cell activation	P00379	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02738	De novo purine biosynthesis	P02901	Adenosuccinate lyase	PYRAE|EnsemblGenome=PAE0972|UniProtKB=Q8ZY28	Adenylosuccinate lyase (PurB)	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MOUSE|MGI=MGI=894644|UniProtKB=Q8CC27	Voltage-dependent L-type calcium channel subunit beta-2	IC	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00251	cPLA2	RAT|RGD=67366|UniProtKB=P50393	Cytosolic phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	DANRE|ZFIN=ZDB-GENE-000210-21|UniProtKB=Q8QGE3	Activin beta A subunit	TAS	11451570	PubMed	PTHR11848:SF133	INHIBIN BETA A CHAIN
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00752	cGMP-gated ion channel	MACMU|Ensembl=ENSMMUG00000017889|UniProtKB=F6Q6B2	Uncharacterized protein	ISS	12432397	PubMed	PTHR10217:SF385	CYCLIC NUCLEOTIDE-GATED CATION CHANNEL BETA-3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01080	AChE	BOVIN|Ensembl=ENSBTAG00000011139|UniProtKB=P32749	Cholinesterase	ISS	87080761	PubMed	PTHR43918:SF5	CHOLINESTERASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00005	Angiogenesis	P00238	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	PANTR|Ensembl=ENSPTRG00000005795|UniProtKB=H2R3J3	Transient receptor potential cation channel, subfamily C, member 4	ISS	11055438	PubMed	PTHR10117:SF25	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 4
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P02743	Formyltetrahydroformate biosynthesis	P02956	Formyl tetrahydrofolate deformylase	BACSU|EnsemblGenome=BSU13110|UniProtKB=O34990	Formyltetrahydrofolate deformylase	ISS			PTHR42706:SF1	FORMYLTETRAHYDROFOLATE DEFORMYLASE 1, MITOCHONDRIAL-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	DROME|FlyBase=FBgn0001991|UniProtKB=Q24270	Voltage-dependent calcium channel type D subunit alpha-1	ISS	11956331	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=1860487|UniProtKB=A0A0A6YY83	Protein Pcdh7	ISS	8120095	PubMed	PTHR43912:SF8	PROTOCADHERIN-7
P00018	EGF receptor signaling pathway	P00539	14-3-3	HUMAN|HGNC=12851|UniProtKB=P62258	14-3-3 protein epsilon	ISS	98119747	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00053	T cell activation	P01315	Calcineurin	CANLF|Ensembl=ENSCAFG00000010644|UniProtKB=F2Z4P5	Serine/threonine-protein phosphatase	ISS	7532676	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P06216	SCW signaling pathway	P06327	TLD	DROME|FlyBase=FBgn0003719|UniProtKB=P25723	Dorsal-ventral patterning protein tolloid	IDA	12925593	PubMed	PTHR43978:SF2	DORSAL-VENTRAL PATTERNING PROTEIN TOLLOID-RELATED
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	HUMAN|HGNC=1950|UniProtKB=P11229	Muscarinic acetylcholine receptor M1	TAS	12915051	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Gene=ACTG2|UniProtKB=P63270	Actin, gamma-enteric smooth muscle	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P02741	Flavin biosynthesis	P02936	FAD synthetase	RHOBA|EnsemblGenome=RB8286|UniProtKB=Q7UFW8	Riboflavin biosynthesis protein	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=1921305|UniProtKB=Q8K4S1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	15611108	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P02773	S-adenosylmethionine biosynthesis	P03142	Cobalamin-dependent homocysteine transmethylase	HUMAN|HGNC=7468|UniProtKB=Q99707	Methionine synthase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00025	Hedgehog signaling pathway	P00682	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00865	Shc	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	ISS	8264585	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	HUMAN|HGNC=403|UniProtKB=P51648	Fatty aldehyde dehydrogenase	RCA			PTHR43570:SF9	FATTY ALDEHYDE DEHYDROGENASE
P04392	P53 pathway feedback loops 1	G04683	Cop-1	BOVIN|Ensembl=ENSBTAG00000031385|UniProtKB=F1MHX1	Uncharacterized protein	ISS	15103385	PubMed	PTHR44080:SF1	E3 UBIQUITIN-PROTEIN LIGASE RFWD2
P00011	Blood coagulation	P00431	tPA	PANTR|Ensembl=ENSPTRG00000020201|UniProtKB=H2QW33	Tissue-type plasminogen activator	ISS	4505861	gi	PTHR44617:SF1	TISSUE-TYPE PLASMINOGEN ACTIVATOR
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=2155600|UniProtKB=Q91Z83	Myosin-7	IC	10938134	PubMed	PTHR13140:SF344	MYOSIN-7
P04397	p53 pathway by glucose deprivation	P04636	S6K	CANLF|Ensembl=ENSCAFG00000017679|UniProtKB=E2RMD8	Ribosomal protein S6 kinase	ISS	11861821	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	MOUSE|MGI=MGI=1351660|UniProtKB=Q9JMK2	Casein kinase I isoform epsilon	IDA	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	RAT|RGD=619877|UniProtKB=P19804	Nucleoside diphosphate kinase B	ISS			PTHR11349:SF57	NUCLEOSIDE DIPHOSPHATE KINASE B
P00035	Interferon-gamma signaling pathway	P00961	STAT1	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00057	Wnt signaling pathway	P01447	Dishevelled	CANLF|Ensembl=ENSCAFG00000019275|UniProtKB=E2QY91	Uncharacterized protein	ISS	12549854	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000006158|UniProtKB=H2R9F4	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF272	CADHERIN-24
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00018	EGF receptor signaling pathway	P00560	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02725	Allantoin degradation	P02819	Glyoxylate carboligase	STRCO|Gene=CAB36609|UniProtKB=Q9Z5A1	Putative glyoxylate carboligase	ISS			PTHR18968:SF14	GLYOXYLATE CARBOLIGASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CAEEL|WormBase=WBGene00000066|UniProtKB=P10986	Actin-4	IC	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00005	Angiogenesis	P00237	FRP	BOVIN|Ensembl=ENSBTAG00000002107|UniProtKB=A7MB15	FZD1 protein	ISS	12549854	PubMed	PTHR11309:SF81	FRIZZLED-1
P00048	PI3 kinase pathway	P01199	Galpha	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	IC	14765990	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	TAS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	RAT|RGD=69319|UniProtKB=P54313	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00053	T cell activation	P01295	vav	CANLF|Ensembl=ENSCAFG00000018590|UniProtKB=E2RGT8	Uncharacterized protein	ISS	10661401	PubMed	PTHR22826:SF112	PROTO-ONCOGENE VAV
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01287	BAMBI	HUMAN|HGNC=30251|UniProtKB=Q13145	BMP and activin membrane-bound inhibitor homolog	TAS	10519551	PubMed	PTHR15505:SF1	BMP AND ACTIVIN MEMBRANE-BOUND INHIBITOR HOMOLOG
P05912	Dopamine receptor mediated signaling pathway	P05963	MAO	CANLF|Gene=MAOB|UniProtKB=Q7YRB7	Amine oxidase [flavin-containing] B	ISS	90344230	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00008	Axon guidance mediated by Slit/Robo	P00344	Netrin	HUMAN|HGNC=23319|UniProtKB=Q9Y2I2	Netrin-G1	ISS			PTHR10574:SF28	NETRIN-G1
P00048	PI3 kinase pathway	P01188	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P02746	Heme biosynthesis	P02970	Coproporphyrinogen oxidase (oxygen independent)	BACSU|EnsemblGenome=BSU25500|UniProtKB=P54304	Oxygen-independent coproporphyrinogen-III oxidase-like protein YqeR	ISS			PTHR13932:SF5	OXYGEN-INDEPENDENT COPROPORPHYRINOGEN-III OXIDASE-LIKE PROTEIN YGGW
P00056	VEGF signaling pathway	P01401	HIF-1	CHICK|Gene=HIF1A|UniProtKB=Q9YIB9	Hypoxia-inducible factor 1-alpha	ISS			PTHR23043:SF7	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA
P00006	Apoptosis signaling pathway	P00303	c-Jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00020	FAS signaling pathway	P00618	CAD	DROME|FlyBase=FBgn0028406|UniProtKB=Q9V3H0	DNAation factor-related protein 4	TAS	10739646	PubMed	PTHR13067:SF2	DNAATION FACTOR-RELATED PROTEIN 4
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01072	CHT1	HUMAN|HGNC=14025|UniProtKB=Q9GZV3	High affinity choline transporter 1	IC			PTHR11819:SF129	HIGH AFFINITY CHOLINE TRANSPORTER 1
P00047	PDGF signaling pathway	P01145	c-fos	CANLF|Ensembl=ENSCAFG00000001829|UniProtKB=F1PH12	Uncharacterized protein	ISS			PTHR11945:SF221	SERUM RESPONSE FACTOR
P00006	Apoptosis signaling pathway	P00284	Flip	HUMAN|HGNC=1876|UniProtKB=O15519	CASP8 and FADD-like apoptosis regulator	IDA	9228018	PubMed	PTHR10454:SF8	CASP8 AND FADD-LIKE APOPTOSIS REGULATOR
P04393	Ras Pathway	P04544	Grb2	CHICK|Gene=GRB2|UniProtKB=Q07883	Growth factor receptor-bound protein 2	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05913	Enkephalin release	P05974	G-Protein (i)	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00021	FGF signaling pathway	P00640	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	PANTR|Ensembl=ENSPTRG00000014576|UniProtKB=H2QLZ9	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00005	Angiogenesis	P00251	cPLA2	HUMAN|HGNC=30038|UniProtKB=Q86XP0	Cytosolic phospholipase A2 delta	ISS			PTHR10728:SF31	CYTOSOLIC PHOSPHOLIPASE A2 DELTA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00059	p53 pathway	G04702	p53	BOVIN|Ensembl=ENSBTAG00000005812|UniProtKB=G3X6J7	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P05916	Opioid prodynorphin pathway	P06002	G-protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	ISS	1482697	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P02738	De novo purine biosynthesis	P02900	AICAR transformylase	YEAST|SGD=S000004018|UniProtKB=P54113	Bifunctional purine biosynthesis protein ADE16	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	XENTR|Xenbase=XB-GENE-1011906|UniProtKB=F6XPD5	Uncharacterized protein (Fragment)	ISS			PTHR11824:SF8	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-3
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00025	Hedgehog signaling pathway	P00692	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00012	Cadherin signaling pathway	P00467	alpha-catenin	MOUSE|MGI=MGI=88274|UniProtKB=P26231	Catenin alpha-1	IDA	9362521	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02738	De novo purine biosynthesis	P02891	GDP kinase	ARATH|TAIR=AT5G63310|UniProtKB=O64903	Nucleoside diphosphate kinase II, chloroplastic	ISS			PTHR11349:SF44	NUCLEOSIDE DIPHOSPHATE KINASE II, CHLOROPLASTIC
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	IC	88234494	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00009	Axon guidance mediated by netrin	P00366	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00010	B cell activation	P00383	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	TAS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P05730	Endogenous cannabinoid signaling	P05746	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00029	Huntington disease	P00776	c-Jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	BOVIN|Ensembl=ENSBTAG00000008967|UniProtKB=P61223	Ras-related protein Rap-1b	ISS	1904317	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00048	PI3 kinase pathway	P01187	IR	PANTR|Ensembl=ENSPTRG00000010386|UniProtKB=H2QF61	Tyrosine-protein kinase receptor	ISS	249616	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00005	Angiogenesis	P00255	Notch	RAT|RGD=3187|UniProtKB=Q07008	Neurogenic locus notch homolog protein 1	ISS	1764995	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00007	Axon guidance mediated by semaphorins	P00341	Rho	HUMAN|HGNC=667|UniProtKB=P61586	Transforming protein RhoA	ISS	12039949	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=1351340|UniProtKB=Q9QYS2	Metabotropic glutamate receptor 3	IDA	12351712	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00018	EGF receptor signaling pathway	P00547	PP2A	DANRE|ZFIN=ZDB-GENE-050417-441|UniProtKB=Q567Y8	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	HUMAN|HGNC=6093|UniProtKB=P14616	Insulin receptor-related protein	TAS	10226785	PubMed	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00057	Wnt signaling pathway	P01451	Galpha	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	IDA	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04547	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00589	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=1351341|UniProtKB=Q68EF4	Metabotropic glutamate receptor 4	ISS	9407094	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000010953|UniProtKB=F1Q376	Phosphoinositide phospholipase C	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00049	Parkinson disease	P01229	Pael-R	PANTR|Ensembl=ENSPTRG00000019646|UniProtKB=H2QVB0	Uncharacterized protein	ISS	12150907	PubMed	PTHR24243:SF32	PROSAPOSIN RECEPTOR GPR37
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00015	Circadian clock system	P00505	Cry	MACMU|Ensembl=ENSMMUG00000021808|UniProtKB=F7ENG9	Cryptochrome-1	ISS	14507900	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	CHLTR|EnsemblGenome=CT_828|UniProtKB=O84835	Ribonucleoside-diphosphate reductase subunit beta	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MONDO|Ensembl=ENSMODG00000001404|UniProtKB=F7BD74	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01219	SAPK	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	NAS	10207617	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000003399|UniProtKB=H2Q383	Phosphoinositide-3-kinase, class 2, alpha polypeptide	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00059	p53 pathway	G04702	p53	HUMAN|HGNC=11998|UniProtKB=P04637	Cellular tumor antigen p53	TAS	11313951	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01395	TFIIE	ARATH|TAIR=AT4G20810|UniProtKB=Q9SVG6	Putative uncharacterized protein AT4g20810	ISS			PTHR13097:SF7	NOVEL PROTEIN SIMILAR TO VERTEBRATE GENERAL TRANSCRIPTION FACTOR IIE POLYPEPTIDE 1 ALPHA 56KDA  GTF2E1
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	BOVIN|Gene=FURIN|UniProtKB=Q28193	Furin	IDA	11861638	PubMed	PTHR42884:SF1	FURIN
P00021	FGF signaling pathway	P00643	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00007	Axon guidance mediated by semaphorins	P00331	PAK	CHICK|Ensembl=ENSGALG00000000681|UniProtKB=E1C3P6	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000011757|UniProtKB=Q9XT97	Presenilin-1	IDA	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	TAS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P02781	Threonine biosynthesis	P03190	Threonine synthase	AQUAE|EnsemblGenome=aq_425|UniProtKB=O66740	Threonine synthase	ISS	9537320	PubMed	PTHR10314:SF5	THREONINE SYNTHASE 1, CHLOROPLASTIC
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	12464394	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00057	Wnt signaling pathway	P01461	FrzB	CANLF|Ensembl=ENSCAFG00000003646|UniProtKB=E2QYI0	Uncharacterized protein	ISS	9118218	PubMed	PTHR11309:SF7	SECRETED FRIZZLED-RELATED PROTEIN 4
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	RAT|RGD=2732|UniProtKB=P22756	Glutamate receptor ionotropic, kainate 1	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00054	Toll receptor signaling pathway	P01373	CD14	BOVIN|Gene=CD14|UniProtKB=Q95122	Monocyte differentiation antigen CD14	ISS			PTHR10630:SF3	MONOCYTE DIFFERENTIATION ANTIGEN CD14
P05731	GABA-B receptor II signaling	P05754	Ggamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	RCA	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=3596|UniProtKB=Q9NYQ8	Protocadherin Fat 2	IDA	8120095	PubMed	PTHR24026:SF37	PROTOCADHERIN FAT 2
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	TAKRU|Ensembl=ENSTRUG00000002863|UniProtKB=H2S2N9	Uncharacterized protein	ISS	9362521	PubMed	PTHR18914:SF29	CATENIN ALPHA-2
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	PANTR|Ensembl=ENSPTRG00000017401|UniProtKB=H2R587	Casein kinase 1, alpha 1	ISS	10617630	PubMed	PTHR11909:SF84	CASEIN KINASE I ISOFORM ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	PANTR|Ensembl=ENSPTRG00000002993|UniProtKB=H2Q2N7	Protein-serine/threonine kinase	RCA			PTHR24355:SF27	G PROTEIN-COUPLED RECEPTOR KINASE 5
P00010	B cell activation	P00391	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00046	Oxidative stress response	P01131	MKP5	CAEEL|WormBase=WBGene00015807|UniProtKB=Q9TY00	Uncharacterized protein	ISS			PTHR10159:SF109	DUAL SPECIFICITY PROTEIN PHOSPHATASE 2
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	XENTR|Xenbase=XB-GENE-956713|UniProtKB=Q5XGD8	Guanine nucleotide binding protein, beta 3	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00545	JNK1-3	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IGI	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00052	TGF-beta signaling pathway	P01275	P38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00011	Blood coagulation	P00421	alpha1-antitrypsin	PANTR|Ensembl=ENSPTRG00000023666|UniProtKB=H2R1G9	Uncharacterized protein	ISS	112888	gi	PTHR11461:SF165	ALPHA-1-ANTITRYPSIN-RELATED
P00049	Parkinson disease	P01213	Cyclin E	XENTR|Xenbase=XB-GENE-972042|UniProtKB=A9UMS1	Cyclin E1	ISS	12628165	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	METAC|EnsemblGenome=MA_4268|UniProtKB=Q8TI88	Proteasome-activating nucleotidase	ISS			PTHR23073:SF31	26S PROTEASE REGULATORY SUBUNIT 10B
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IC	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	ISS	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	ARATH|TAIR=AT4G34460|UniProtKB=P49177	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF48	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA
P00056	VEGF signaling pathway	P01417	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00049	Parkinson disease	P01236	Casein kinase II	ORYSJ|EnsemblGenome=OS07G0495100|UniProtKB=Q84RS4	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00015	Circadian clock system	P00502	Casein kinase I	PANTR|Ensembl=ENSPTRG00000009796|UniProtKB=H2QE47	Casein kinase 1, delta	ISS	10617630	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00005	Angiogenesis	P00182	p38MAPK	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04395	Vasopressin synthesis	P04597	Signal Peptide	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00012	Cadherin signaling pathway	P00470	F-actin	CAEBR|Gene=CBG23091|UniProtKB=A8Y4Q9	Protein CBR-ACT-2	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00053	T cell activation	P01332	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05730	Endogenous cannabinoid signaling	P05751	Galpha	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00017	DNA replication	P00527	Histones	RAT|RGD=621095|UniProtKB=P84245	Histone H3.3	ISS	20448842	PubMed	PTHR11426:SF166	HISTONE H3.3
P00047	PDGF signaling pathway	P01143	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00001	Adrenaline and noradrenaline biosynthesis	P00066	DOPA decarb.	ANOGA|Gene=AgaP_AGAP009091|UniProtKB=Q7PW49	AGAP009091-PA	ISS	90339966	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00223	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00029	Huntington disease	P00775	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	TAS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02918	dUTP pyrophosphatase	BRADU|EnsemblGenome=BAC46023|UniProtKB=O52597	Deoxyuridine 5'-triphosphate nucleotidohydrolase	ISS			PTHR11241:SF0	BCDNA.LD08534
P04393	Ras Pathway	P04541	p90RSK	HUMAN|HGNC=10432|UniProtKB=P51812	Ribosomal protein S6 kinase alpha-3	IDA	6755374	gi	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=1921305|UniProtKB=Q8K4S1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	7822322	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00053	T cell activation	P01315	Calcineurin	MOUSE|MGI=MGI=107162|UniProtKB=P48455	Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform	IGI	12015605	PubMed	PTHR11668:SF186	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT GAMMA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	ENTHI|EnsemblGenome=EHI_129750|UniProtKB=C4M5Q7	Rho family GTPase	ISS			PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00057	Wnt signaling pathway	P01446	Calcineurin	MONDO|Ensembl=ENSMODG00000020679|UniProtKB=F7DKU1	Serine/threonine-protein phosphatase	ISS	7532676	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04569	Cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00053	T cell activation	P01300	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06959	CCKR signaling map	P07217	MAPKAP-K2	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	RCA	9727040	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00038	JAK/STAT signaling pathway	P01034	Jak	RAT|RGD=2939|UniProtKB=Q62689	Tyrosine-protein kinase JAK2	ISS	22482294	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00021	FGF signaling pathway	P00627	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	DANRE|ZFIN=ZDB-GENE-980526-176|UniProtKB=Q90459	G1/S-specific cyclin-D1	IEP	12356903	PubMed	PTHR10177:SF67	G1/S-SPECIFIC CYCLIN-D1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MACMU|Ensembl=ENSMMUG00000010184|UniProtKB=F6SR09	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT3G59790|UniProtKB=Q9M1Z5	Mitogen-activated protein kinase 10	ISS	9836510	gi	PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	BOVIN|Ensembl=ENSBTAG00000011757|UniProtKB=Q9XT97	Presenilin-1	TAS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00037	Ionotropic glutamate receptor pathway	P01006	NR2C	RAT|RGD=2739|UniProtKB=Q00961	Glutamate receptor ionotropic, NMDA 2C	ISS	11554549	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	PANTR|Ensembl=ENSPTRG00000003983|UniProtKB=H2Q4A0	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	MOUSE|MGI=MGI=109521|UniProtKB=P35363	5-hydroxytryptamine receptor 2A	ISS	12441358	PubMed	PTHR24247:SF30	5-HYDROXYTRYPTAMINE RECEPTOR 2A
P00047	PDGF signaling pathway	P01143	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01226	CDCrel-1	HUMAN|HGNC=9164|UniProtKB=Q99719	Septin-5	IDA	11078524	PubMed	PTHR18884:SF68	SEPTIN-5
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	LEIMA|EnsemblGenome=LmjF.35.4010|UniProtKB=Q9GNR4	Protein kinase A catalytic subunit isoform 1	ISS	10218114	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02738	De novo purine biosynthesis	P02907	dADP kinase	MACMU|Ensembl=ENSMMUG00000003857|UniProtKB=F7HA84	Nucleoside diphosphate kinase	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P00021	FGF signaling pathway	P00640	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00053	T cell activation	P01306	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01368	MKK2	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CANLF|Ensembl=ENSCAFG00000015708|UniProtKB=F2Z4N0	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P02772	Pyruvate metabolism	P03140	Pyruvate Carboxylase	CAEBR|Gene=CBG23262|UniProtKB=A8Y4B9	Pyruvate carboxylase	ISS	11761713	PubMed	PTHR43778:SF2	PYRUVATE CARBOXYLASE, MITOCHONDRIAL
P00029	Huntington disease	P00786	ARF	CANLF|Ensembl=ENSCAFG00000002318|UniProtKB=E2RNQ0	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF139	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 4A
P00049	Parkinson disease	P01236	Casein kinase II	CHICK|Ensembl=ENSGALG00000006197|UniProtKB=P21868	Casein kinase II subunit alpha	IDA	10617630	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P04395	Vasopressin synthesis	P04593	Glycopeptide	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	IC	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TRIVA|Gene=TVAG_337240|UniProtKB=P90623	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	RAT|RGD=2027|UniProtKB=P63269	Actin, gamma-enteric smooth muscle	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P02738	De novo purine biosynthesis	P02902	ADP reductase	NEUCR|EnsemblGenome=EFNCRG00000002605|UniProtKB=Q9UW15	Ribonucleoside-diphosphate reductase large chain	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P05913	Enkephalin release	P05974	G-Protein (i)	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	IC	1482697	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8972|UniProtKB=O00750	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MOUSE|MGI=MGI=102705|UniProtKB=P63213	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IDA	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00049	Parkinson disease	P01208	Hsp70	CHICK|Gene_ORFName=RCJMB04_2m8|UniProtKB=Q5ZM98	Stress-70 protein, mitochondrial	ISS	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	DANRE|ZFIN=ZDB-GENE-020102-1|UniProtKB=F1QCB2	Uncharacterized protein	ISS	4503175	gi	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000014751|UniProtKB=H2R8D8	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00048	PI3 kinase pathway	P01182	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	DICDI|dictyBase=DDB_G0286355|UniProtKB=P08799	Myosin-2 heavy chain	IC			PTHR13140:SF555	MYOSIN HEAVY CHAIN, MUSCLE
P00024	Glycolysis	P00679	Aldolase	HUMAN|HGNC=414|UniProtKB=P04075	Fructose-bisphosphate aldolase A	ISS	6086339	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00034	Integrin signalling pathway	P00944	Actin	XENTR|Xenbase=XB-GENE-491618|UniProtKB=Q6P378	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00057	Wnt signaling pathway	P01435	SWI/SNF	PSEAE|EnsemblGenome=PA0799|UniProtKB=Q9I5D9	Probable helicase	ISS	11532957	PubMed	PTHR10799:SF845	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A CONTAINING DEAD/H BOX 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000022319|UniProtKB=F6XDA0	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00056	VEGF signaling pathway	P01408	Akt/PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00467	alpha-catenin	PANTR|Ensembl=ENSPTRG00000017291|UniProtKB=H2QRK9	Catenin (Cadherin-associated protein), alpha 1, 102kDa	ISS	10456847	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00006	Apoptosis signaling pathway	P00313	IKK	BOVIN|Ensembl=ENSBTAG00000007599|UniProtKB=Q95KV0	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00034	Integrin signalling pathway	P00945	Parvin	HUMAN|HGNC=14652|UniProtKB=Q9NVD7	Alpha-parvin	IPI	11331308	PubMed	PTHR12114:SF6	ALPHA-PARVIN
P00006	Apoptosis signaling pathway	P00303	c-Jun	CHICK|Gene=JUN|UniProtKB=P18870	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P05913	Enkephalin release	P05977	G-Protein (s)	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00011	Blood coagulation	P00443	Fibrin polymer cross-linked	PANTR|Ensembl=ENSPTRG00000016536|UniProtKB=H2RDH7	Uncharacterized protein	ISS	80015086	PubMed	PTHR19143:SF338	FIBRINOGEN GAMMA CHAIN
P00059	p53 pathway	P01480	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	RCA	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	ORYSJ|EnsemblGenome=OS09G0440300|UniProtKB=Q69P84	Aldehyde dehydrogenase	IC			PTHR43521:SF1	ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06794	MAP2K1/2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	RCA	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02738	De novo purine biosynthesis	P02898	Phosphoribosylformylglycinamide  synthase	CAEEL|WormBase=WBGene00008654|UniProtKB=Q19311	Probable phosphoribosylformylglycinamidine synthase	ISS			PTHR10099:SF1	PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE
P00015	Circadian clock system	P00502	Casein kinase I	MONDO|Ensembl=ENSMODG00000003587|UniProtKB=F7FPX9	Uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01407	Erk	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00059	p53 pathway	P04634	Cdc2	TRYB2|Gene=Tb927.7.7360|UniProtKB=Q57TX3	Cell division control protein 2 homolog 2	ISS			PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P00057	Wnt signaling pathway	P01443	Phospholipase C	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00005	Angiogenesis	P00211	GSK3beta	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00565	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IGI	10747026	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00018	EGF receptor signaling pathway	P00539	14-3-3	USTMA|Gene=UMAG_01366|UniProtKB=A0A0D1E7J2	Chromosome 2, whole genome shotgun sequence	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00046	Oxidative stress response	P01134	cPLA2	CHICK|Ensembl=ENSGALG00000005065|UniProtKB=P49147	Cytosolic phospholipase A2	TAS	94299545	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00021	FGF signaling pathway	P00632	Akt	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	IGI	14526383	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04560	AP1	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	HUMAN|HGNC=1424|UniProtKB=P27708	CAD protein	ISS			PTHR11405:SF5	CAD PROTEIN
P00005	Angiogenesis	P00193	SOS-1	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	RCA	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01295	vav	PANTR|Ensembl=ENSPTRG00000021525|UniProtKB=H2QY48	Uncharacterized protein	ISS	14623913	PubMed	PTHR22826:SF95	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	TAS	15572354	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00212	EphR	MOUSE|MGI=MGI=99611|UniProtKB=P54763	Ephrin type-B receptor 2	ISS	9990854	PubMed	PTHR24416:SF123	EPHRIN TYPE-B RECEPTOR 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01471	alpha-catenin	MONDO|Ensembl=ENSMODG00000015456|UniProtKB=F6S406	Uncharacterized protein	ISS	1768802	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P00006	Apoptosis signaling pathway	P00260	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00001	Adrenaline and noradrenaline biosynthesis	P00061	PNMT	HUMAN|HGNC=9160|UniProtKB=P11086	Phenylethanolamine N-methyltransferase	ISS	12438093	PubMed	PTHR10867:SF18	PHENYLETHANOLAMINE N-METHYLTRANSFERASE
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05918	p38 MAPK pathway	P05919	MAPKAP-K3	PANTR|Ensembl=ENSPTRG00000014968|UniProtKB=H2QMP5	Mitogen-activated protein kinase-activated protein kinase 3	ISS	11335727	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	BOVIN|Ensembl=ENSBTAG00000018035|UniProtKB=O46680	TGF-beta receptor type-1	TAS	10683140	PubMed	PTHR23255:SF61	TGF-BETA RECEPTOR TYPE-1
P05915	Opioid proenkephalin pathway	P05994	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-040718-93|UniProtKB=Q6DGZ5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00020	FAS signaling pathway	P00616	Nuclear Lamin	BOVIN|Ensembl=ENSBTAG00000017574|UniProtKB=F1MYG5	Uncharacterized protein	ISS	11165516	PubMed	PTHR23239:SF158	PRELAMIN-A/C
P00012	Cadherin signaling pathway	P00471	Cadherin	CHICK|Ensembl=ENSGALG00000012942|UniProtKB=F1NPQ8	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF106	CADHERIN-18
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	CHICK|Ensembl=ENSGALG00000002859|UniProtKB=F6UBD2	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00056	VEGF signaling pathway	P01423	p38MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00010	B cell activation	P00391	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01409	cPLA2	RAT|RGD=67366|UniProtKB=P50393	Cytosolic phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	PANTR|Ensembl=ENSPTRG00000004233|UniProtKB=H2Q4N9	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	CAEEL|WormBase=WBGene00000050|UniProtKB=P91197	AcetylCholine Receptor	IC	11404397	PubMed	PTHR18945:SF436	ACETYLCHOLINE RECEPTOR
P00034	Integrin signalling pathway	P00925	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P06959	CCKR signaling map	G07291	GCG	HUMAN|HGNC=4191|UniProtKB=P01275	Glucagon	RCA		PubMed	PTHR11418:SF0	GLUCAGON
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02759	Pyridoxal-5-phosphate biosynthesis	P03058	Phosphohydroxythreonine aminotransferase	BACTN|EnsemblGenome=BT_1153|UniProtKB=Q8A8L4	Phosphoserine aminotransferase	ISS			PTHR43247:SF2	PHOSPHOSERINE AMINOTRANSFERASE
P00024	Glycolysis	P00680	Phosphoglyceromutase	STRCO|EnsemblGenome=CAC04045|UniProtKB=P33158	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase	ISS	21996410	PubMed	PTHR11931:SF31	SUBFAMILY NOT NAMED
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS	15470041	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04393	Ras Pathway	P04565	MKK4/7	BOVIN|Ensembl=ENSBTAG00000012103|UniProtKB=A5PJP8	MAP2K4 protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00056	VEGF signaling pathway	P01411	Ras	DANRE|ZFIN=ZDB-GENE-990415-166|UniProtKB=P79737	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00565	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IGI	15572354	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	ARATH|TAIR=AT2G31300|UniProtKB=Q9SJW6	Actin-related protein 2/3 complex subunit 1B	ISS	12963527	gi	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P00021	FGF signaling pathway	P00642	MEK1-2	CAEBR|Gene=CBG04190|UniProtKB=A8WWD7	Protein CBR-MEK-2	ISS	22022015	PubMed	PTHR24361:SF629	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	XENTR|Xenbase=XB-GENE-961282|UniProtKB=Q6DF43	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	XENTR|Ensembl=ENSXETG00000024231|UniProtKB=F6TCQ4	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ORYSJ|EnsemblGenome=OS03G0285800|UniProtKB=Q10N20	Mitogen-activated protein kinase 5	ISS	95284341	PubMed	PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00566	ERK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	NAS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	BOVIN|Ensembl=ENSBTAG00000047202|UniProtKB=G3N3K3	Uncharacterized protein	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00052	TGF-beta signaling pathway	P01275	P38	CAEEL|WormBase=WBGene00004056|UniProtKB=Q8MXI4	Mitogen-activated protein kinase pmk-2	TAS	11274345	PubMed	PTHR24055:SF154	MITOGEN-ACTIVATED PROTEIN KINASE PMK-2
P02785	Valine biosynthesis	P03218	Dihydroxy isovalerate dehydratase	LEPIN|EnsemblGenome=LA_2959|UniProtKB=Q8F219	Dihydroxy-acid dehydratase	ISS			PTHR21000:SF5	DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	XENTR|Xenbase=XB-GENE-1009886|UniProtKB=F7DYM9	Uncharacterized protein	ISS			PTHR13140:SF255	UNCONVENTIONAL MYOSIN-IC
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	ISS	9851932	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02748	Isoleucine biosynthesis	P02998	Dihydroxyacid dehydratase	ECOLI|EcoGene=EG12549|UniProtKB=P39358	Uncharacterized protein YjhG	ISS			PTHR43661:SF2	SUBFAMILY NOT NAMED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	12805548	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	MACMU|Ensembl=ENSMMUG00000021075|UniProtKB=F7GY91	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	ISS	20032362	PubMed	PTHR24055:SF330	SUBFAMILY NOT NAMED
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	EMENI|EnsemblGenome=CADANIAG00002670|UniProtKB=Q5BH99	G-protein beta subunit [Source:UniProtKB/TrEMBLAcc:O74214]	ISS	10523303	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	IGI	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00019	Endothelin signaling pathway	P00578	eNOS	MONDO|Ensembl=ENSMODG00000003903|UniProtKB=F6S3S1	Nitric oxide synthase	ISS	10435050	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00018	EGF receptor signaling pathway	P00560	Raf-1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	ANOGA|EnsemblGenome=AGAP006718|UniProtKB=Q7QI86	AGAP006718-PA	ISS	94365697	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P02778	Sulfate assimilation	P03167	Sulfate adenylyltransferase	BACSU|EnsemblGenome=BSU15590|UniProtKB=O34764	Sulfate adenylyltransferase	ISS			PTHR43509:SF1	SUBFAMILY NOT NAMED
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00890	ELK	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	ISS	12660819	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01275	P38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	TAS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00005	Angiogenesis	P00211	GSK3beta	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	22533439	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	XENTR|Xenbase=XB-GENE-487200|UniProtKB=Q28GC2	Catenin (Cadherin associated protein), beta 1, 88kDa	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00046	Oxidative stress response	P01135	p38	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	TAS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00046	Oxidative stress response	P01129	JNK1/2	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00002	Alpha adrenergic receptor signaling pathway	P00078	Alpha1A/1B/1C	BOVIN|Ensembl=ENSBTAG00000040253|UniProtKB=F1MGA6	Uncharacterized protein	ISS	11781138	PubMed	PTHR24248:SF17	ALPHA-1B ADRENERGIC RECEPTOR
P00053	T cell activation	P01316	MHC-antigen	PANTR|Ensembl=ENSPTRG00000017417|UniProtKB=H2QRT2	Uncharacterized protein	ISS	73139	PubMed	PTHR14093:SF17	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN GAMMA CHAIN
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P02763	Peptidoglycan biosynthesis	P03091	D-alanine-D-alanine ligase	GLOVI|EnsemblGenome=BAC88238|UniProtKB=Q7NNW1	D-alanine--D-alanine ligase	ISS			PTHR23132:SF12	D-ALANINE--D-ALANINE LIGASE B
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00057	Wnt signaling pathway	P01443	Phospholipase C	DROME|FlyBase=FBgn0004611|UniProtKB=P25455	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II	IDA	15611108	PubMed	PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	ISS	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01444	Wnt	BOVIN|Ensembl=ENSBTAG00000015364|UniProtKB=E1BEN9	Protein Wnt	ISS	14644163	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00046	Oxidative stress response	P01135	p38	CAEEL|WormBase=WBGene00004055|UniProtKB=Q17446	Mitogen-activated protein kinase pmk-1	TAS	22138445	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00897	SHIP2	MACMU|Ensembl=ENSMMUG00000010451|UniProtKB=F7CRA7	Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2	ISS	12145149	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00005	Angiogenesis	P00247	Tie2	PANTR|Ensembl=ENSPTRG00000020835|UniProtKB=H2QX37	Uncharacterized protein	ISS	1630810	PubMed	PTHR24416:SF125	ANGIOPOIETIN-1 RECEPTOR
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00019	Endothelin signaling pathway	P00572	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MACMU|Ensembl=ENSMMUG00000020810|UniProtKB=F7H7P6	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF84	PROTEIN WNT-9B
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00053	T cell activation	P01336	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	PANTR|Ensembl=ENSPTRG00000014760|UniProtKB=H2QMB3	Serine/threonine-protein kinase receptor	ISS	9395284	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P04393	Ras Pathway	P04557	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	IDA	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00034	Integrin signalling pathway	P00938	Cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00006	Apoptosis signaling pathway	P00269	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01160	IP3 receptor	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	PANTR|Ensembl=ENSPTRG00000001102|UniProtKB=H2QZR9	RAP1A, member of RAS oncogene family	ISS	10476970	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DICDI|dictyBase=DDB_G0268744|UniProtKB=Q55EU6	Putative actin-23	IC	11889126	PubMed	PTHR11937:SF154	ACTIN-17-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	ORNAN|Ensembl=ENSOANG00000011166|UniProtKB=F7D5G3	Phosphoinositide phospholipase C	ISS			PTHR10336:SF84	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2
P04371	5-Hydroxytryptamine biosynthesis	P04400	Aromatic L-amino acid decarboxylase	RAT|RGD=2494|UniProtKB=P14173	Aromatic-L-amino-acid decarboxylase	IEA	7567987	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00006	Apoptosis signaling pathway	P00318	PKCs	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	XENTR|Xenbase=XB-GENE-491938|UniProtKB=Q6DIV8	Actin, alpha 1, skeletal muscle	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347736|UniProtKB=E9FRT1	Muscle-specific actin	ISS	11889126	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000015640|UniProtKB=E2QVF3	Uncharacterized protein	ISS	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	RCA	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	IC	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00047	PDGF signaling pathway	P01159	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MONDO|Ensembl=ENSMODG00000001775|UniProtKB=F6WJB1	Uncharacterized protein	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	MOUSE|MGI=MGI=109576|UniProtKB=Q6PDZ2	TATA box-binding protein-associated factor RNA polymerase I subunit C	ISS	604905	OMIM	PTHR15319:SF1	TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT C
P00018	EGF receptor signaling pathway	P00546	GAP	HUMAN|HGNC=9872|UniProtKB=Q15283	Ras GTPase-activating protein 2	ISS	20475167	gi	PTHR10194:SF21	RAS GTPASE-ACTIVATING PROTEIN 2
P05913	Enkephalin release	P05974	G-Protein (i)	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	BRAFL|Gene=BRAFLDRAFT_220697|UniProtKB=C3ZSF0	Putative uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	TAS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00587	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	RAT|RGD=71098|UniProtKB=P97633	Casein kinase I isoform alpha	ISS	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BOVIN|Ensembl=ENSBTAG00000003043|UniProtKB=P63212	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00034	Integrin signalling pathway	P00907	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01336	Jnk	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	P01448	CBP	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00047	PDGF signaling pathway	P01154	Ras	ENTHI|EnsemblGenome=EHI_137700|UniProtKB=Q24806	Ras family GTPase	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00036	Interleukin signaling pathway	P00973	PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04398	p53 pathway feedback loops 2	P04657	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05913	Enkephalin release	P05977	G-Protein (s)	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00005	Angiogenesis	P00188	Ets	ORNAN|Ensembl=ENSOANG00000012104|UniProtKB=F7FH70	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IC	2837282	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	CANLF|Ensembl=ENSCAFG00000004381|UniProtKB=J9JH96	Uncharacterized protein	ISS	7476890	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P04393	Ras Pathway	P04557	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IDA	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000002647|UniProtKB=F7DIB7	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00003	Alzheimer disease-amyloid secretase pathway	P00089	Pen-2	ANOGA|EnsemblGenome=AGAP008094|UniProtKB=Q7Q3Y1	AGAP008094-PA	IDA	12110170	PubMed	PTHR16318:SF0	GAMMA-SECRETASE SUBUNIT PEN-2
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	IDA	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00019	Endothelin signaling pathway	P00586	Gq	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IGI	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05918	p38 MAPK pathway	P06040	MSK1	PANTR|Ensembl=ENSPTRG00000006631|UniProtKB=H2Q8S3	Ribosomal protein S6 kinase	ISS	9687510	PubMed	PTHR24351:SF115	RIBOSOMAL PROTEIN S6 KINASE ALPHA-5
P00021	FGF signaling pathway	P00624	14-3-3	BOVIN|Ensembl=ENSBTAG00000005664|UniProtKB=P62261	14-3-3 protein epsilon	ISS	98119747	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IDA	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00005	Angiogenesis	P00230	PDGFR	CHICK|Gene=PDGFRA|UniProtKB=Q9PUF6	Platelet-derived growth factor receptor alpha	ISS			PTHR24416:SF52	PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA
P00058	mRNA splicing	P01473	U6	MOUSE|MGI=MGI=1918017|UniProtKB=Q922U1	U4/U6 small nuclear ribonucleoprotein Prp3	ISS	12875835	PubMed	PTHR14212:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9407|UniProtKB=Q15139	Serine/threonine-protein kinase D1	ISS	12393506	PubMed	PTHR22968:SF9	SERINE/THREONINE-PROTEIN KINASE D1
P00047	PDGF signaling pathway	P01142	p90RSK	PANTR|Ensembl=ENSPTRG00000003839|UniProtKB=H2Q401	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF41	RIBOSOMAL PROTEIN S6 KINASE ALPHA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IDA	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02742	Tetrahydrofolate biosynthesis	P02944	Phosphoribosylglycinamide formyltransferase	MYCTU|EnsemblGenome=Rv2964|UniProtKB=P9WHM3	Formyltetrahydrofolate deformylase	ISS			PTHR42706:SF1	FORMYLTETRAHYDROFOLATE DEFORMYLASE 1, MITOCHONDRIAL-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00019	Endothelin signaling pathway	P00570	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00566	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	BOVIN|Ensembl=ENSBTAG00000020485|UniProtKB=P17870	Beta-arrestin-1	IDA	11742073	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Ensembl=ENSCAFG00000011689|UniProtKB=E2QZY2	Uncharacterized protein	ISS	11259487	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01179	PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00925	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	PANTR|Ensembl=ENSPTRG00000004963|UniProtKB=H2Q5Y5	Serine/threonine-protein kinase receptor	ISS	9395284	PubMed	PTHR23255:SF66	SERINE/THREONINE-PROTEIN KINASE RECEPTOR R3
P05916	Opioid prodynorphin pathway	P06002	G-protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00021	FGF signaling pathway	P00648	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00778	NMDA receptor	HUMAN|HGNC=4587|UniProtKB=Q14957	Glutamate receptor ionotropic, NMDA 2C	IDA	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P05915	Opioid proenkephalin pathway	P05994	G-protein	RAT|RGD=621516|UniProtKB=G3V6P8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P02738	De novo purine biosynthesis	P02911	N5-carboxyaminoimidazole ribonucleotide mutase	FUSNN|EnsemblGenome=FN0989|UniProtKB=Q8REV0	N5-carboxyaminoimidazole ribonucleotide mutase	ISS			PTHR23046:SF2	N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE MUTASE
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P06664	Gonadotropin-releasing hormone receptor pathway	P06847	JNK1/2	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	RCA	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00059	p53 pathway	P04623	CBP	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00047	PDGF signaling pathway	P01175	Shc	MACMU|Ensembl=ENSMMUG00000020357|UniProtKB=F6W915	SHC-transforming protein 3	ISS	96404502	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P00005	Angiogenesis	P00248	Ang-1	MOUSE|MGI=MGI=108448|UniProtKB=O08538	Angiopoietin-1	ISS	8980223	PubMed	PTHR19143:SF156	ANGIOPOIETIN-1
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CHICK|Ensembl=ENSGALG00000008898|UniProtKB=F1P2J9	Uncharacterized protein	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	CHICK|Ensembl=ENSGALG00000027629|UniProtKB=Q5ZJ03	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00021	FGF signaling pathway	P00629	PP2A	CAEEL|WormBase=WBGene00004085|UniProtKB=Q9XW79	Serine/threonine-protein phosphatase 4 catalytic subunit 1	IGI			PTHR11668:SF22	SERINE/THREONINE-PROTEIN PHOSPHATASE 4 CATALYTIC SUBUNIT
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00951	Jnk	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IDA	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000008190|UniProtKB=H2QB92	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF89	CADHERIN-5
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00807	Actin	CANLF|Ensembl=ENSCAFG00000016020|UniProtKB=O18840	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00048	PI3 kinase pathway	P01192	p110	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	HUMAN|HGNC=1952|UniProtKB=P20309	Muscarinic acetylcholine receptor M3	ISS	8100450	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000008503|UniProtKB=F6TGJ6	Uncharacterized protein	ISS	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	21186066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	ARATH|TAIR=AT5G61210|UniProtKB=Q9S7P9	SNAP25 homologous protein SNAP33	IC			PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	ARATH|TAIR=AT4G08800|UniProtKB=F4JID0	Protein kinase family protein	IDA	10617630	PubMed	PTHR11909:SF298	CASEIN KINASE 1-LIKE PROTEIN 12-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01390	TFIIA complex	MOUSE|MGI=MGI=1933277|UniProtKB=Q99PM3	Transcription initiation factor IIA subunit 1	ISS	600519	OMIM	PTHR12694:SF7	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DICPU|Gene=DICPUDRAFT_93216|UniProtKB=F1A421	Guanine nucleotide-binding protein subunit beta	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00790	beta-Tubulin	CAEEL|WormBase=WBGene00003171|UniProtKB=P12456	Tubulin beta-1 chain	TAS	9454836	PubMed	PTHR11588:SF255	TUBA7L PROTEIN
P00049	Parkinson disease	P01230	Src kinase	PANTR|Ensembl=ENSPTRG00000009824|UniProtKB=H2QE70	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF90	TYROSINE-PROTEIN KINASE YES
P02775	Salvage pyrimidine ribonucleotides	P03149	Cytidine kinase	ARATH|TAIR=AT4G26510|UniProtKB=O65583	Uridine kinase-like protein 4	ISS			PTHR10285:SF97	URIDINE KINASE-LIKE PROTEIN 3-RELATED
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	ORYSJ|EnsemblGenome=OS02G0735200|UniProtKB=P14656	Glutamine synthetase cytosolic isozyme 1-1	ISS			PTHR20852:SF79	GLUTAMINE SYNTHETASE CYTOSOLIC ISOZYME 1-1-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00059	p53 pathway	P04616	PDK1/2	ORYSJ|EnsemblGenome=OS01G0872800|UniProtKB=Q8RUE8	Os01g0872800 protein	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05961	DOPA decarb.	MOUSE|MGI=MGI=94876|UniProtKB=O88533	Aromatic-L-amino-acid decarboxylase	ISS	107930	OMIM	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00017	DNA replication	P00533	Pol delta	PLAF7|EnsemblGenome=PF10_0165|UniProtKB=Q7KQL4	DNA polymerase	ISS	92107655	PubMed	PTHR10322:SF23	DNA POLYMERASE DELTA CATALYTIC SUBUNIT
P00056	VEGF signaling pathway	P01417	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05730	Endogenous cannabinoid signaling	P05746	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00219	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	PANTR|Ensembl=ENSPTRG00000006872|UniProtKB=H2RCB4	Uncharacterized protein	ISS	15858232	PubMed	PTHR13715:SF16	RYANODINE RECEPTOR 3
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	DANRE|ZFIN=ZDB-GENE-990415-25|UniProtKB=P79733	Ribonucleoside-diphosphate reductase subunit M2	ISS			PTHR23409:SF20	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	DANRE|ZFIN=ZDB-GENE-040116-1|UniProtKB=Q7ZUQ0	Actin related protein 2/3 complex, subunit 1A	ISS	12473693	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00833	RGS	MOUSE|MGI=MGI=1927498|UniProtKB=Q99PG4	Regulator of G-protein signaling 18	IDA	11563974	PubMed	PTHR10845:SF155	REGULATOR OF G-PROTEIN SIGNALING 18
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04393	Ras Pathway	P04558	p38	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	IDA	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P02738	De novo purine biosynthesis	P02898	Phosphoribosylformylglycinamide  synthase	PANTR|Ensembl=ENSPTRG00000008735|UniProtKB=H2QC76	Phosphoribosylformylglycinamidine synthase	ISS			PTHR10099:SF1	PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00012	Cadherin signaling pathway	P00470	F-actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g169611|UniProtKB=A7SEB1	Predicted protein	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PLAF7|EnsemblGenome=PFL2215w|UniProtKB=Q8I4X0	Actin-1	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00018	EGF receptor signaling pathway	P00559	MEK1-2	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02738	De novo purine biosynthesis	P02907	dADP kinase	ORYSJ|EnsemblGenome=OS07G0492000|UniProtKB=Q07661	Nucleoside diphosphate kinase 1	ISS			PTHR11349:SF66	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01154	Ras	DANRE|ZFIN=ZDB-GENE-040808-67|UniProtKB=Q6AZA4	K-ras	ISS	20362513	PubMed	PTHR24070:SF186	GTPASE KRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	PANTR|Ensembl=ENSPTRG00000009472|UniProtKB=H2QZP7	Clathrin heavy chain	ISS	9388255	PubMed	PTHR10292:SF7	CLATHRIN HEAVY CHAIN 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	BOVIN|Ensembl=ENSBTAG00000015252|UniProtKB=F1MDD1	Uncharacterized protein	ISS			PTHR18945:SF489	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-9
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	XENTR|Xenbase=XB-GENE-493937|UniProtKB=Q5M8T9	Actin, alpha 2, smooth muscle, aorta	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04665	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00023	General transcription regulation	P00658	TBP-associated factors	RAT|RGD=1311608|UniProtKB=Q63801	Transcription initiation factor TFIID subunit 6	ISS			PTHR10221:SF12	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04398	p53 pathway feedback loops 2	G04715	CYCLIN G	BOVIN|Ensembl=ENSBTAG00000006607|UniProtKB=Q5E9I1	Cyclin-G1	ISS	15077171	PubMed	PTHR10177:SF59	CYCLIN-G1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	CAEEL|WormBase=WBGene00001622|UniProtKB=Q22682	Putative sodium-dependent excitatory amino acid transporter glt-4	ISS	96032356	PubMed	PTHR11958:SF56	SODIUM-DEPENDENT EXCITATORY AMINO ACID TRANSPORTER GLT-4-RELATED
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MACMU|Ensembl=ENSMMUG00000009054|UniProtKB=F7F735	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00034	Integrin signalling pathway	P00925	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	IDA	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=12774|UniProtKB=P04628	Proto-oncogene Wnt-1	IDA	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00012	Cadherin signaling pathway	P00470	F-actin	RAT|RGD=1310826|UniProtKB=Q5M7U6	Actin-related protein 2	ISS	11889126	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P04393	Ras Pathway	P04568	MKK3/6	MOUSE|MGI=MGI=1346868|UniProtKB=O09110	Dual specificity mitogen-activated protein kinase kinase 3	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00057	Wnt signaling pathway	P01443	Phospholipase C	DROME|FlyBase=FBgn0004611|UniProtKB=P25455	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II	IDA	7822322	PubMed	PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MACMU|Ensembl=ENSMMUG00000013995|UniProtKB=F6RRN8	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF155	REGULATOR OF G-PROTEIN SIGNALING 18
P04398	p53 pathway feedback loops 2	P04668	p53	MOUSE|MGI=MGI=98834|UniProtKB=P02340	Cellular tumor antigen p53	TAS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00049	Parkinson disease	P01230	Src kinase	RAT|RGD=620795|UniProtKB=Q9WUD9	Proto-oncogene tyrosine-protein kinase Src	IDA	8054685	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04623	CBP	ARATH|TAIR=AT1G16710|UniProtKB=Q9FWQ5	Histone acetyltransferase HAC12	ISS	10823891	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00048	PI3 kinase pathway	P01179	PKB	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	TAS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	CHICK|Ensembl=ENSGALG00000017178|UniProtKB=F1N982	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P05731	GABA-B receptor II signaling	P05754	Ggamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	RCA	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04398	p53 pathway feedback loops 2	G04714	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	IGI	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_60743|UniProtKB=C3XYD4	Putative uncharacterized protein	ISS			PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	TAKRU|Ensembl=ENSTRUG00000008175|UniProtKB=H2T716	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF26	REGULATOR OF G-PROTEIN SIGNALING 7
P00005	Angiogenesis	P00206	Wnt	CAEBR|Gene=CBG03422|UniProtKB=A8WV10	Protein CBR-CWN-2	ISS	8717036	PubMed	PTHR12027:SF77	PROTEIN WNT-5
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	RAT|RGD=1597456|UniProtKB=D4A898	Protein Tbpl1	ISS	600075	OMIM	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00011	Blood coagulation	P00449	GP Ibalpha	MOUSE|MGI=MGI=1333744|UniProtKB=O35930	Platelet glycoprotein Ib alpha chain	IDA	98060358	PubMed	PTHR45534:SF1	PLATELET GLYCOPROTEIN IB ALPHA CHAIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00049	Parkinson disease	P01242	Casein kinase I	CAEBR|Gene=CBG20206|UniProtKB=A8XX71	Protein CBR-KIN-19	ISS	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00034	Integrin signalling pathway	P00924	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IPI	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01407	Erk	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00775	Rac	ENTHI|EnsemblGenome=EHI_070730|UniProtKB=C4M5T0	Rho family GTPase	TAS			PTHR24072:SF117	RHO-RELATED PROTEIN RACC
P00017	DNA replication	P00533	Pol delta	BOVIN|Ensembl=ENSBTAG00000012241|UniProtKB=P49004	DNA polymerase delta subunit 2	ISS	12522211	PubMed	PTHR10416:SF0	DNA POLYMERASE DELTA SUBUNIT 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	20027584	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MOUSE|MGI=MGI=87906|UniProtKB=P63260	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	PANTR|Ensembl=ENSPTRG00000008769|UniProtKB=H2R9J3	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF681	MYOSIN-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00014	Cholesterol biosynthesis	P00499	Farnesyl-diphosphate farnesyltransferase	MOUSE|MGI=MGI=102706|UniProtKB=P53798	Squalene synthase	ISS			PTHR11626:SF2	SQUALENE SYNTHASE
P00053	T cell activation	P01296	TCR zeta	PANTR|Ensembl=ENSPTRG00000023523|UniProtKB=H2R2L9	Uncharacterized protein	ISS	9012833	PubMed	PTHR10035:SF2	T-CELL SURFACE GLYCOPROTEIN CD3 ZETA CHAIN
P04393	Ras Pathway	P04552	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IDA	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00046	Oxidative stress response	P01132	c-jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05916	Opioid prodynorphin pathway	P06001	AC	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CHICK|Ensembl=ENSGALG00000007794|UniProtKB=A9YZQ5	Dopamine receptor 2 protein transcript variant 1	ISS	11861492	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	MOUSE|MGI=MGI=2444680|UniProtKB=Q8K009	Mitochondrial 10-formyltetrahydrofolate dehydrogenase	IC			PTHR11699:SF131	MITOCHONDRIAL 10-FORMYLTETRAHYDROFOLATE DEHYDROGENASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00127	APP	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00059	p53 pathway	G01571	FAS	HUMAN|HGNC=11920|UniProtKB=P25445	Tumor necrosis factor receptor superfamily member 6	IGI	14585074	PubMed	PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	PANTR|Ensembl=ENSPTRG00000001791|UniProtKB=H2R8B2	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF32	REGULATOR OF G-PROTEIN SIGNALING 13
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	PANTR|Ensembl=ENSPTRG00000010105|UniProtKB=H2QEP3	Suppressor of cytokine signaling 6	ISS	12645661	PubMed	PTHR44562:SF1	SUPPRESSOR OF CYTOKINE SIGNALING 6
P00001	Adrenaline and noradrenaline biosynthesis	P00067	MAO	DANRE|ZFIN=ZDB-GENE-040329-3|UniProtKB=Q6NSN2	Amine oxidase [flavin-containing]	ISS	8602220	PubMed	PTHR43563:SF2	AMINE OXIDASE  FLAVIN-CONTAINING
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=69424|UniProtKB=Q99P84	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	12860966	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00029	Huntington disease	P00779	TBP	MACMU|Ensembl=ENSMMUG00000019917|UniProtKB=F6SEF6	Uncharacterized protein	ISS	11988536	PubMed	PTHR10126:SF20	TATA-BOX-BINDING PROTEIN
P00021	FGF signaling pathway	P00632	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1354946|UniProtKB=Q61532	Mitogen-activated protein kinase 6	IDA	8444355	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	MOUSE|MGI=MGI=109284|UniProtKB=Q61144	Presenilin-2	IDA	12885769	PubMed	PTHR10202:SF13	PRESENILIN-2
P00005	Angiogenesis	P00227	PLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00029	Huntington disease	P00782	alpha-Adaptin	BOVIN|Gene=AP2A2|UniProtKB=Q0VCK5	AP-2 complex subunit alpha-2	ISS	11532990	PubMed	PTHR22780:SF4	AP-2 COMPLEX SUBUNIT ALPHA-2
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CHICK|Gene=WNT2B|UniProtKB=Q98SN7	Protein Wnt-2b	TAS	11266476	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P06959	CCKR signaling map	G06968	HBEGF	HUMAN|HGNC=3059|UniProtKB=Q99075	Proheparin-binding EGF-like growth factor	RCA	9869605	PubMed	PTHR10740:SF4	PROHEPARIN-BINDING EGF-LIKE GROWTH FACTOR
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	IDA	18021322	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00021	FGF signaling pathway	P00629	PP2A	SCLS1|Gene=SS1G_07871|UniProtKB=A7ERB7	Protein phosphatase PP2A regulatory subunit B	ISS	9987122	PubMed	PTHR11871:SF0	PROTEIN PHOSPHATASE PP2A 55 KDA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	IDA	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	RAT|RGD=1304749|UniProtKB=A0A0G2K0H3	Protein Lrp6	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	HUMAN|HGNC=4401|UniProtKB=O14775	Guanine nucleotide-binding protein subunit beta-5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00029	Huntington disease	P00767	Pro-caspase 8	RAT|RGD=620945|UniProtKB=Q9JHX4	Caspase-8	IDA	11788820	PubMed	PTHR10454:SF162	CASPASE-8
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00057	Wnt signaling pathway	P01451	Galpha	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MOUSE|MGI=MGI=102522|UniProtKB=Q8R3Z5	Voltage-dependent L-type calcium channel subunit beta-1	IC	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P04393	Ras Pathway	P04542	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01320	PLC-gamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00021	FGF signaling pathway	P00638	PLCgamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00022	General transcription by RNA polymerase I	P00652	RNA Polymerase I  Complex	HUMAN|HGNC=20454|UniProtKB=Q9H9Y6	DNA-directed RNA polymerase I subunit RPA2	ISS	15691654	PubMed	PTHR20856:SF5	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA2
P00029	Huntington disease	P00780	Microtubule	HUMAN|HGNC=20771|UniProtKB=P68371	Tubulin beta-4B chain	IDA	9454836	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00057	Wnt signaling pathway	P01428	Frizzled	BOVIN|Ensembl=ENSBTAG00000002107|UniProtKB=A7MB15	FZD1 protein	ISS	8717036	PubMed	PTHR11309:SF81	FRIZZLED-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05731	GABA-B receptor II signaling	P05754	Ggamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04397	p53 pathway by glucose deprivation	P04641	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01185	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00322	Cytochrome C	HUMAN|HGNC=19986|UniProtKB=P99999	Cytochrome c	ISS			PTHR11961:SF15	CYTOCHROME C
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00053	T cell activation	P01312	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	IDA	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	XENTR|Xenbase=XB-GENE-481916|UniProtKB=F6YF14	Presenilin	ISS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00019	Endothelin signaling pathway	P00590	IP3 R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04393	Ras Pathway	P04572	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	RAT|RGD=621060|UniProtKB=O88777	Presenilin-2	TAS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00645	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00559	MEK1-2	ORYSJ|EnsemblGenome=OS01G0510100|UniProtKB=Q5QN75	Mitogen-activated protein kinase kinase 1	ISS			PTHR24361:SF616	MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P05913	Enkephalin release	P05974	G-Protein (i)	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MACMU|Ensembl=ENSMMUG00000001353|UniProtKB=F7D6T8	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	TAKRU|Ensembl=ENSTRUG00000017773|UniProtKB=H2V8M1	Uncharacterized protein (Fragment)	IDA	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MONDO|Ensembl=ENSMODG00000005623|UniProtKB=F7CFG8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=3233|UniProtKB=P33533	Delta-type opioid receptor	IDA	11259498	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00049	Parkinson disease	P01211	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00775	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00036	Interleukin signaling pathway	P00983	Raf	MOUSE|MGI=MGI=88190|UniProtKB=P28028	Serine/threonine-protein kinase B-raf	ISS	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	11035810	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000025240|UniProtKB=F7A7I3	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00021	FGF signaling pathway	P00634	MEKK1-5	PANTR|Ensembl=ENSPTRG00000012427|UniProtKB=H2QIN7	Mitogen-activated protein kinase kinase kinase 2	ISS	8621389	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00021	FGF signaling pathway	P00628	JNK1-3	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00056	VEGF signaling pathway	P01413	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=1351341|UniProtKB=Q68EF4	Metabotropic glutamate receptor 4	ISS	12488551	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00020	FAS signaling pathway	P00615	JNK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00029	Huntington disease	P00780	Microtubule	ASHGO|EnsemblGenome=AGOS_ACR225C|UniProtKB=Q75BP6	ACR225Cp	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04393	Ras Pathway	P04556	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00005	Angiogenesis	P00203	Erk	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01324	rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12676940	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000000365|UniProtKB=F6R9F4	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	DANRE|ZFIN=ZDB-GENE-051202-2|UniProtKB=Q6ZM67	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF3	SUBFAMILY NOT NAMED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00645	Rac	ORYSJ|EnsemblGenome=OS02G0834000|UniProtKB=Q6EP31	Rac-like GTP-binding protein 5	ISS			PTHR24072:SF194	RAC-LIKE GTP-BINDING PROTEIN ARAC4-RELATED
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	HUMAN|HGNC=4574|UniProtKB=P48058	Glutamate receptor 4	ISS	10331083	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	HUMAN|HGNC=4544|UniProtKB=P34947	G protein-coupled receptor kinase 5	IDA	8288567	PubMed	PTHR24355:SF27	G PROTEIN-COUPLED RECEPTOR KINASE 5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MOUSE|MGI=MGI=99673|UniProtKB=P84309	Adenylate cyclase type 5	ISS	1409703	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P02766	Phenylethylamine degradation	P03103	Phenylethylamine oxidase	RAT|RGD=61296|UniProtKB=P36633	Amiloride-sensitive amine oxidase [copper-containing]	ISS			PTHR10638:SF3	AMILORIDE-SENSITIVE AMINE OXIDASE  COPPER-CONTAINING
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	RAT|RGD=61973|UniProtKB=Q9JMI9	Short transient receptor potential channel 3	ISS	11055438	PubMed	PTHR10117:SF8	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00018	EGF receptor signaling pathway	P00547	PP2A	TAKRU|Ensembl=ENSTRUG00000011169|UniProtKB=H2TU36	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00048	PI3 kinase pathway	P01192	p110	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	TAKRU|Ensembl=ENSTRUG00000007253|UniProtKB=H2SZQ1	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00019	Endothelin signaling pathway	P00573	signal peptidase	ARATH|TAIR=AT1G52600|UniProtKB=Q9SSR2	Signal peptidase I	ISS	2092035	PubMed	PTHR10806:SF16	SIGNAL PEPTIDASE I
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	10188796	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00006	Apoptosis signaling pathway	P00269	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	IDA	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00051	TCA cycle	P01268	Aconitase	AQUAE|EnsemblGenome=aq_1784|UniProtKB=O67656	Aconitase	ISS	15606842	gi	PTHR43160:SF3	ACONITATE HYDRATASE, MITOCHONDRIAL
P02738	De novo purine biosynthesis	P02904	Guanylate kinase	DROME|FlyBase=FBgn0036099|UniProtKB=Q9VTB3	GH06691p	ISS			PTHR23117:SF13	GUANYLATE KINASE
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00006	Apoptosis signaling pathway	P00317	Fos	MONDO|Ensembl=ENSMODG00000005927|UniProtKB=F6WX28	Uncharacterized protein	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04398	p53 pathway feedback loops 2	P04651	Ras	CHICK|Ensembl=ENSGALG00000006885|UniProtKB=P08642	GTPase HRas	ISS	3035212	PubMed	PTHR24070:SF385	GTPASE HRAS
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	CHICK|Ensembl=ENSGALG00000002932|UniProtKB=O57535	Nucleoside diphosphate kinase	ISS			PTHR11349:SF57	NUCLEOSIDE DIPHOSPHATE KINASE B
P00017	DNA replication	P00532	Hel	RAT|RGD=1306791|UniProtKB=D3ZG52	DNA replication ATP-dependent helicase/nuclease DNA2	RCA			PTHR10887:SF14	DNA REPLICATION ATP-DEPENDENT HELICASE/NUCLEASE DNA2
P00059	p53 pathway	P04623	CBP	MACMU|Ensembl=ENSMMUG00000000893|UniProtKB=F6T7D0	Histone acetyltransferase p300	ISS	8413673	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	MONDO|Ensembl=ENSMODG00000010516|UniProtKB=F7DR73	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P00005	Angiogenesis	P00199	JNKK1	MONDO|Ensembl=ENSMODG00000008266|UniProtKB=F6Z879	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_56687|UniProtKB=C3YC50	Putative uncharacterized protein	IDA	3487386	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P05913	Enkephalin release	P05977	G-Protein (s)	MOUSE|MGI=MGI=95777|UniProtKB=Q6R0H7	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas	IC	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P02734	Chorismate biosynthesis	P02869	3-Dehydroquinate dehydratase	BACTN|EnsemblGenome=BT_2842|UniProtKB=Q8A3W2	3-dehydroquinate dehydratase	ISS			PTHR21272:SF3	SUBFAMILY NOT NAMED
P00053	T cell activation	P01336	Jnk	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IGI	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	HUMAN|HGNC=5299|UniProtKB=Q13639	5-hydroxytryptamine receptor 4	IDA	15118808	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PANTR|Ensembl=ENSPTRG00000009762|UniProtKB=H2QE24	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	RAT|RGD=1305144|UniProtKB=D4AE24	Ribosomal protein S6 kinase	ISS	15116068	PubMed	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00059	p53 pathway	P01486	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	TAS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04544	Grb2	DANRE|ZFIN=ZDB-GENE-040426-1975|UniProtKB=Q6PC73	Growth factor receptor-bound protein 2	ISS	8479536	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	DROME|FlyBase=FBgn0019947|UniProtKB=O02194	Presenilin homolog	TAS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	YEAST|SGD=S000006239|UniProtKB=P32288	Glutamine synthetase	ISS			PTHR20852:SF57	GLUTAMINE SYNTHETASE 2 CYTOPLASMIC
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00951	Jnk	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00006	Apoptosis signaling pathway	P00272	ASK1	HUMAN|HGNC=6857|UniProtKB=Q99683	Mitogen-activated protein kinase kinase kinase 5	IDA	12566458	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	PANTR|Ensembl=ENSPTRG00000017612|UniProtKB=C7G3N0	Glutamate receptor, metabotropic 6	ISS	9407094	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00012	Cadherin signaling pathway	P00469	Fer	PANTR|Ensembl=ENSPTRG00000017117|UniProtKB=H2QRA6	Tyrosine-protein kinase	ISS	9742093	PubMed	PTHR24418:SF227	TYROSINE-PROTEIN KINASE FER
P00004	Alzheimer disease-presenilin pathway	P00147	TACE	BOVIN|Ensembl=ENSBTAG00000001141|UniProtKB=G3MZB3	Uncharacterized protein	ISS	9774383	PubMed	PTHR11905:SF171	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17
P00029	Huntington disease	P00790	beta-Tubulin	CAEEL|WormBase=WBGene00000248|UniProtKB=Q18817	Uncharacterized protein	TAS	12932731	PubMed	PTHR11588:SF120	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00790	beta-Tubulin	PHYPA|Gene=PHYPADRAFT_117822|UniProtKB=A9RQS1	Predicted protein	ISS	9454836	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P00008	Axon guidance mediated by Slit/Robo	P00355	Rho	HUMAN|HGNC=669|UniProtKB=P08134	Rho-related GTP-binding protein RhoC	ISS	14871999	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	XENTR|Xenbase=XB-GENE-1010483|UniProtKB=F7AF72	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00059	p53 pathway	G01568	KILLER/DR5	HUMAN|HGNC=11905|UniProtKB=O14763	Tumor necrosis factor receptor superfamily member 10B	IGI	9242611	PubMed	PTHR23097:SF88	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10B
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	CHICK|Ensembl=ENSGALG00000002003|UniProtKB=F1P3H0	Receptor protein serine/threonine kinase	TAS	10683140	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	PANTR|Ensembl=ENSPTRG00000000843|UniProtKB=H2QZN8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	8457205	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P04393	Ras Pathway	P04568	MKK3/6	HUMAN|HGNC=6846|UniProtKB=P52564	Dual specificity mitogen-activated protein kinase kinase 6	RCA			PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00057	Wnt signaling pathway	P01438	PP2A	MONDO|Ensembl=ENSMODG00000019001|UniProtKB=F7CP86	Serine/threonine-protein phosphatase	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01167	Ets	HUMAN|HGNC=3488|UniProtKB=P14921	Protein C-ets-1	ISS	15699632	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00029	Huntington disease	P00796	Kainate receptor	CHICK|Ensembl=ENSGALG00000006638|UniProtKB=R4GGL9	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00057	Wnt signaling pathway	P01431	LRP5/6	MOUSE|MGI=MGI=1278315|UniProtKB=Q91VN0	Low-density lipoprotein receptor-related protein 5	ISS	11907044	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	TAS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00059	p53 pathway	P04634	Cdc2	SCHPO|PomBase=SPBC11B10.09|UniProtKB=P04551	Cyclin-dependent kinase 1	ISS			PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IGI	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=99401|UniProtKB=Q60612	Adenosine receptor A1	ISS	11781138	PubMed	PTHR24246:SF1	ADENOSINE RECEPTOR A1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02723	Adenine and hypoxanthine salvage pathway	P02812	Deoxyinosine phosphorylase	THEMA|EnsemblGenome=TM_1737|UniProtKB=Q9X259	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00054	Toll receptor signaling pathway	P01352	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PHYIT|EnsemblGenome=PITG_15078|UniProtKB=D0NRL5	Actin-like protein	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	P01440	Cadherin	CHICK|Gene=CDH11|UniProtKB=O93319	Cadherin-11	IDA	8120095	PubMed	PTHR24027:SF85	CADHERIN-11
P00047	PDGF signaling pathway	P01159	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	XENTR|Xenbase=XB-GENE-491618|UniProtKB=Q6P378	Actin, cytoplasmic 2	ISS	11889139	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00054	Toll receptor signaling pathway	P01377	MyD88	HUMAN|HGNC=7562|UniProtKB=Q99836	Myeloid differentiation primary response protein MyD88	ISS			PTHR15079:SF3	MYELOID DIFFERENTIATION PRIMARY RESPONSE PROTEIN MYD88
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05731	GABA-B receptor II signaling	P05754	Ggamma	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	RCA	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05731	GABA-B receptor II signaling	P05758	K channel	MOUSE|MGI=MGI=104742|UniProtKB=P63250	G protein-activated inward rectifier potassium channel 1	RCA	12374786	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PHYPA|Gene=PHYPADRAFT_109052|UniProtKB=A9TZ58	Actin 5	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ARATH|TAIR=AT1G73670|UniProtKB=Q9C9U4	Mitogen-activated protein kinase 15	IDA			PTHR24055:SF246	MITOGEN-ACTIVATED PROTEIN KINASE 15-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	RAT|RGD=3187|UniProtKB=Q07008	Neurogenic locus notch homolog protein 1	IDA	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P02738	De novo purine biosynthesis	P02904	Guanylate kinase	YEAST|SGD=S000002862|UniProtKB=P15454	Guanylate kinase	ISS			PTHR23117:SF13	GUANYLATE KINASE
P00029	Huntington disease	P00774	Dynein complex	TETTS|EnsemblGenome=TTHERM_00046310|UniProtKB=Q23DR0	Dynein heavy chain, cytoplasmic protein	IPI	9454836	PubMed	PTHR10676:SF314	CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1
P00046	Oxidative stress response	P01131	MKP5	HUMAN|HGNC=3065|UniProtKB=Q9Y6W6	Dual specificity protein phosphatase 10	TAS	10597297	PubMed	PTHR10159:SF299	DUAL SPECIFICITY PROTEIN PHOSPHATASE 10
P00019	Endothelin signaling pathway	P00568	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00022	General transcription by RNA polymerase I	P00654	TTF-I	HUMAN|HGNC=12397|UniProtKB=Q15361	Transcription termination factor 1	IGI	95320168	PubMed	PTHR10641:SF939	TRANSCRIPTION TERMINATION FACTOR 1
P04398	p53 pathway feedback loops 2	P04657	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	PANTR|Ensembl=ENSPTRG00000008769|UniProtKB=H2R9J3	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF681	MYOSIN-4
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00059	p53 pathway	P04633	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05994	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DICDI|dictyBase=DDB_G0285429|UniProtKB=P21900	Adenylosuccinate synthetase	IEP	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00009	Axon guidance mediated by netrin	P00366	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	4757952	gi	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00034	Integrin signalling pathway	P00925	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00022	General transcription by RNA polymerase I	P00649	TAF-IC	DROME|FlyBase=FBgn0022724|UniProtKB=Q9VWY6	Transcription initiation factor TFIID subunit 8	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	BOVIN|Ensembl=ENSBTAG00000020136|UniProtKB=A5D7B9	CASK protein	ISS	11430913	PubMed	PTHR23122:SF40	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P00038	JAK/STAT signaling pathway	P01031	PIAS	BOVIN|Ensembl=ENSBTAG00000005564|UniProtKB=Q24JZ9	Protein inhibitor of activated STAT, 1	ISS	8682149	PubMed	PTHR10782:SF11	E3 SUMO-PROTEIN LIGASE PIAS1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=894282|UniProtKB=O08858	Somatostatin receptor type 5	IDA	12562507	PubMed	PTHR24229:SF20	SOMATOSTATIN RECEPTOR TYPE 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04373	5HT1 type receptor mediated signaling pathway	P04407	K+ channel	RAT|RGD=621451|UniProtKB=Q9ES08	Potassium channel subfamily K member 9	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000012036|UniProtKB=F7ALP1	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00048	PI3 kinase pathway	P01202	p85	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MOUSE|MGI=MGI=1336171|UniProtKB=Q9DAS9	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IDA	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00045	Notch signaling pathway	P01118	Numb	CAEEL|WormBase=WBGene00003830|UniProtKB=Q9XTY6	Numb-related protein 1	ISS			PTHR11232:SF45	PROTEIN NUMB
P06959	CCKR signaling map	P07099	PKA-Calpha/beta/gamma	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	RCA	7935349	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	HUMAN|HGNC=2093|UniProtKB=P53675	Clathrin heavy chain 2	IDA	9388255	PubMed	PTHR10292:SF6	CLATHRIN HEAVY CHAIN 2
P04398	p53 pathway feedback loops 2	P04651	Ras	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	IDA	12104050	PubMed	PTHR24070:SF189	GTPASE NRAS
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00057	Wnt signaling pathway	P01444	Wnt	RAT|RGD=69346|UniProtKB=G3V7U3	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00056	VEGF signaling pathway	P01425	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05734	Synaptic vesicle trafficking	P05779	Synaptobrevin	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	RCA	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	RAT|RGD=2342|UniProtKB=P08482	Muscarinic acetylcholine receptor M1	ISS	8100450	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P06664	Gonadotropin-releasing hormone receptor pathway	P06782	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	RCA	91072385	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01419	Ets	BOVIN|Ensembl=ENSBTAG00000002341|UniProtKB=A5PJG9	ETS1 protein	ISS	15579511	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00021	FGF signaling pathway	P00632	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05918	p38 MAPK pathway	P06022	eEF2K	PANTR|Ensembl=ENSPTRG00000007877|UniProtKB=H2QAR0	Eukaryotic elongation factor-2 kinase	ISS	11500363	PubMed	PTHR14187:SF56	EUKARYOTIC ELONGATION FACTOR 2 KINASE
P00053	T cell activation	P01303	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8479536	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00057	Wnt signaling pathway	P01432	Beta-Catenin	XENTR|Xenbase=XB-GENE-487200|UniProtKB=Q28GC2	Catenin (Cadherin associated protein), beta 1, 88kDa	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	IC	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00006	Apoptosis signaling pathway	P00310	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02748	Isoleucine biosynthesis	P02998	Dihydroxyacid dehydratase	GLOVI|EnsemblGenome=BAC91109|UniProtKB=Q7NGK1	Dihydroxy-acid dehydratase	ISS			PTHR21000:SF5	DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	SCHMA|EnsemblGenome=Smp_020170|UniProtKB=G4V8E3	Voltage-dependent calcium channel (Fragment)	ISS	14624853	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00038	JAK/STAT signaling pathway	P01034	Jak	MOUSE|MGI=MGI=96629|UniProtKB=Q62120	Tyrosine-protein kinase JAK2	ISS	12686512	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P05918	p38 MAPK pathway	P06020	p38delta	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	RCA	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00193	SOS-1	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00211	GSK3beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00047	PDGF signaling pathway	P01174	Rho	CANLF|Ensembl=ENSCAFG00000013151|UniProtKB=E2RED4	Uncharacterized protein	ISS			PTHR15377:SF4	RHO GTPASE-ACTIVATING PROTEIN 5
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MONDO|Gene=KRAS|UniProtKB=Q07983	GTPase KRas	ISS	3023884	PubMed	PTHR24070:SF186	GTPASE KRAS
P02776	Serine glycine biosynthesis	P03160	Phosphoglycerate dehydrogenase	YEAST|SGD=S000000883|UniProtKB=P40054	D-3-phosphoglycerate dehydrogenase 1	ISS			PTHR10996:SF165	D-3-PHOSPHOGLYCERATE DEHYDROGENASE 1-RELATED
P00046	Oxidative stress response	P01135	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00049	Parkinson disease	P01242	Casein kinase I	ARATH|TAIR=AT5G43320|UniProtKB=Q9LSX4	Casein kinase 1-like protein 8	IDA	10617630	PubMed	PTHR11909:SF178	CASEIN KINASE 1-LIKE PROTEIN 8
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05754	Ggamma	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00057	Wnt signaling pathway	P01443	Phospholipase C	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00049	Parkinson disease	P01235	Fyn kinase	HUMAN|HGNC=4037|UniProtKB=P06241	Tyrosine-protein kinase Fyn	IDA	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	MOUSE|MGI=MGI=97364|UniProtKB=O35516	Neurogenic locus notch homolog protein 2	IDA	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00019	Endothelin signaling pathway	P00589	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00211	GSK3beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	RAT|RGD=619966|UniProtKB=F1LQT1	Adenylate cyclase 7	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P02770	Pyridoxal phosphate salvage pathway	P03120	Pyridoxamine-5-phosphate oxidase	BOVIN|Ensembl=ENSBTAG00000012259|UniProtKB=Q5E9K3	Pyridoxine-5'-phosphate oxidase	ISS	14697241	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000017341|UniProtKB=Q5DRD5	Protocadherin beta-14	ISS	8120095	PubMed	PTHR24028:SF81	PROTOCADHERIN BETA-14
P00048	PI3 kinase pathway	P01182	Ras	YEAST|SGD=S000005042|UniProtKB=P01120	Ras-like protein 2	ISS	7997267	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00019	Endothelin signaling pathway	P00572	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	HUMAN|HGNC=1951|UniProtKB=P08172	Muscarinic acetylcholine receptor M2	TAS	11166329	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P05731	GABA-B receptor II signaling	P05752	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00634	MEKK1-5	MACMU|Ensembl=ENSMMUG00000018568|UniProtKB=F6YLW2	Uncharacterized protein	ISS	8649450	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00056	VEGF signaling pathway	P01421	Rac	MACMU|Ensembl=ENSMMUG00000007831|UniProtKB=F7CI83	Rho GTPase-activating protein 1	ISS			PTHR23176:SF28	RHO GTPASE-ACTIVATING PROTEIN 1
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	HUMAN|HGNC=20289|UniProtKB=Q8N752	Casein kinase I isoform alpha-like	ISS	11437445	PubMed	PTHR11909:SF139	CASEIN KINASE I ISOFORM ALPHA-LIKE
P00049	Parkinson disease	P01234	GRK	MOUSE|MGI=MGI=87940|UniProtKB=Q99MK8	Beta-adrenergic receptor kinase 1	IDA	10852916	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TAKRU|Ensembl=ENSTRUG00000005494|UniProtKB=P53483	Actin, alpha anomalous	IC	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	HUMAN|HGNC=235|UniProtKB=Q8NFM4	Adenylate cyclase type 4	ISS	2491850	PubMed	PTHR11920:SF286	ADENYLATE CYCLASE TYPE 4
P04393	Ras Pathway	P04559	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	20010089	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	ORYSJ|EnsemblGenome=OS10G0563700|UniProtKB=Q7XC37	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00017	DNA replication	P00527	Histones	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g230009|UniProtKB=A7SEB4	Predicted protein	ISS	12413958	PubMed	PTHR11426:SF180	SUBFAMILY NOT NAMED
P06587	Nicotine pharmacodynamics pathway	P06614	TH	RAT|RGD=3853|UniProtKB=P04177	Tyrosine 3-monooxygenase	RCA	191290	OMIM	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	DICDI|dictyBase=DDB_G0277143|UniProtKB=P36408	Guanine nucleotide-binding protein subunit beta	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	CANLF|Ensembl=ENSCAFG00000028654|UniProtKB=J9P702	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00005	Angiogenesis	P00223	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BOVIN|Ensembl=ENSBTAG00000006189|UniProtKB=P63258	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00007	Axon guidance mediated by semaphorins	P00340	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P02752	Mannose metabolism	P03019	P-Mannose mutase	HUMAN|HGNC=9114|UniProtKB=Q92871	Phosphomannomutase 1	ISS	11042159	PubMed	PTHR10466:SF1	PHOSPHOMANNOMUTASE 1
P00057	Wnt signaling pathway	P01446	Calcineurin	SCLS1|EnsemblGenome=SS1G_00214|UniProtKB=A7E4J2	Calcineurin B subunit	ISS	12015605	PubMed	PTHR23056:SF4	PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1
P00004	Alzheimer disease-presenilin pathway	P00162	Pro-BACE-1	BOVIN|Ensembl=ENSBTAG00000019365|UniProtKB=Q2HJ40	Beta-secretase 1	ISS	10531052	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00012	Cadherin signaling pathway	P00470	F-actin	TRIAD|EnsemblGenome=TriadG63375|UniProtKB=B3S5E4	Non-muscle actin 6.2	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00010	B cell activation	P00401	jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00020	FAS signaling pathway	P00620	CytochromeC	LEIMA|EnsemblGenome=LmjF.07.0060|UniProtKB=Q4QIT8	Putative cytochrome c1, heme protein,mitochondrial	ISS	9027315	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02729	Ascorbate degradation	P02852	L-xylulose-5-phosphate-3-epimerase	MONDO|Ensembl=ENSMODG00000015827|UniProtKB=F7FDW3	Ribulose-phosphate 3-epimerase	ISS			PTHR11749:SF3	RIBULOSE-PHOSPHATE 3-EPIMERASE
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	P01451	Galpha	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IDA	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	PANTR|Gene=DRD2|UniProtKB=P60026	D(2) dopamine receptor	ISS	2137198	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00047	PDGF signaling pathway	P01174	Rho	MOUSE|MGI=MGI=1924714|UniProtKB=Q812A5	Proline-rich protein 5	ISS			PTHR32428:SF4	PROLINE-RICH PROTEIN 5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00048	PI3 kinase pathway	P01200	SHIP	HUMAN|HGNC=6076|UniProtKB=Q14642	Type I inositol 1,4,5-trisphosphate 5-phosphatase	TAS			PTHR12997:SF2	TYPE I INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00019	Endothelin signaling pathway	P00575	furin	RAT|RGD=3274|UniProtKB=P23377	Furin	IGI	10956649	PubMed	PTHR42884:SF1	FURIN
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	STRCO|EnsemblGenome=CAB93363|UniProtKB=Q9KXR6	Carbamoyl-phosphate synthase large chain	ISS			PTHR11405:SF5	CAD PROTEIN
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CANLF|Ensembl=ENSCAFG00000002044|UniProtKB=P63210	Guanine nucleotide-binding protein G(T) subunit gamma-T1	ISS	3100519	PubMed	PTHR13809:SF26	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT GAMMA-T1
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	MOUSE|MGI=MGI=106677|UniProtKB=Q8BRU6	Synaptic vesicular amine transporter	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00038	JAK/STAT signaling pathway	P01027	STAT	MACMU|Ensembl=ENSMMUG00000010705|UniProtKB=F7G8V4	Signal transducer and activator of transcription	ISS	95236292	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	DROME|FlyBase=FBgn0004619|UniProtKB=Q03445	Glutamate receptor 1	IC	12941441	PubMed	PTHR18966:SF270	GLUTAMATE RECEPTOR 1-RELATED
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	RAT|RGD=621705|UniProtKB=Q8VHN2	Glutamate receptor ionotropic, NMDA 3B	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	PSEAE|EnsemblGenome=PA0342|UniProtKB=Q9I6F1	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_114976|UniProtKB=C3YP58	Putative uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00009	Axon guidance mediated by netrin	P00364	cdc42	MOUSE|MGI=MGI=1916831|UniProtKB=Q9EQT3	Rho-related GTP-binding protein RhoU	ISS			PTHR24072:SF148	RHO-RELATED GTP-BINDING PROTEIN RHOU
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00010	B cell activation	P00381	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	SYNY3|Gene=BAA17764|UniProtKB=P73717	tRNA-specific adenosine deaminase	ISS			PTHR11079:SF149	TRNA-SPECIFIC ADENOSINE DEAMINASE
P00045	Notch signaling pathway	P01104	Serrate	MACMU|Ensembl=ENSMMUG00000018116|UniProtKB=F7FGM9	Delta-like protein	ISS	8955070	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00029	Huntington disease	P00799	JNK-2	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00059	p53 pathway	P04609	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	HUMAN|HGNC=1950|UniProtKB=P11229	Muscarinic acetylcholine receptor M1	TAS	11166329	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00046	Oxidative stress response	P01131	MKP5	MOUSE|MGI=MGI=1922469|UniProtKB=Q8VE01	Dual specificity protein phosphatase 18	TAS			PTHR10159:SF313	DUAL SPECIFICITY PROTEIN PHOSPHATASE 18
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00053	T cell activation	P01307	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01457	GBeta	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	CAEEL|WormBase=WBGene00001746|UniProtKB=Q9U2Q9	Glycogen synthase kinase-3	TAS			PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00010	B cell activation	P00371	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CAEEL|WormBase=WBGene00001187|UniProtKB=Q8MQA1	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P05916	Opioid prodynorphin pathway	P06002	G-protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	MOUSE|MGI=MGI=1345192|UniProtKB=Q9WVJ2	26S proteasome non-ATPase regulatory subunit 13	ISS	99239941	PubMed	PTHR10539:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01018	Glu1	DROME|FlyBase=FBgn0004619|UniProtKB=Q03445	Glutamate receptor 1	ISS	8804111	PubMed	PTHR18966:SF270	GLUTAMATE RECEPTOR 1-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04395	Vasopressin synthesis	P04594	Neurophysin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00036	Interleukin signaling pathway	P00970	Interleukin	PANTR|Ensembl=ENSPTRG00000018273|UniProtKB=H2QT64	Uncharacterized protein	ISS			PTHR44866:SF1	INTERLEUKIN-17A
P00020	FAS signaling pathway	P00602	DAXX	PANTR|Ensembl=ENSPTRG00000018045|UniProtKB=H2QST5	Uncharacterized protein	ISS	9215629	PubMed	PTHR12766:SF7	DEATH DOMAIN-ASSOCIATED PROTEIN 6
P00045	Notch signaling pathway	G01541	E(spl)-C genes	RAT|RGD=1305022|UniProtKB=D3ZIH3	Hairy/enhancer-of-split related with YRPW motif-like (Predicted)	ISS	10860664	PubMed	PTHR10985:SF79	HAIRY/ENHANCER-OF-SPLIT RELATED WITH YRPW MOTIF-LIKE PROTEIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	MONDO|Ensembl=ENSMODG00000004410|UniProtKB=F6SV58	Uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF322	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04573	Elk-1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	IDA	11151091	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	DANRE|ZFIN=ZDB-GENE-990603-12|UniProtKB=O73864	Protein Wnt-11	TAS	8717036	PubMed	PTHR12027:SF34	PROTEIN WNT
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00036	Interleukin signaling pathway	P00990	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04542	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00013	Cell cycle	P00480	Proteasome	HUMAN|HGNC=9557|UniProtKB=O00232	26S proteasome non-ATPase regulatory subunit 12	ISS	9426256	PubMed	PTHR10855:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12
P00047	PDGF signaling pathway	P01174	Rho	MOUSE|MGI=MGI=2448556|UniProtKB=Q8K031	StAR-related lipid transfer protein 8	ISS	8288572	PubMed	PTHR12659:SF3	STAR-RELATED LIPID TRANSFER PROTEIN 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEEL|WormBase=WBGene00018620|UniProtKB=O44588	Uncharacterized protein	IC	3755548	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00944	Actin	MONDO|Ensembl=ENSMODG00000025240|UniProtKB=F7A7I3	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01318	PKC-theta	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04395	Vasopressin synthesis	P04597	Signal Peptide	MACMU|Ensembl=ENSMMUG00000010678|UniProtKB=F7AXI7	Uncharacterized protein	ISS	6717565	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	IC	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01443	Phospholipase C	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	CAEEL|WormBase=WBGene00006416|UniProtKB=Q27522	Probable S-adenosylmethionine synthase 5	ISS			PTHR11964:SF1	S-ADENOSYLMETHIONINE SYNTHASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00052	TGF-beta signaling pathway	P01275	P38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	TAS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00049	Parkinson disease	P01211	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	8787761	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00965	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	IC	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01417	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MACMU|Ensembl=ENSMMUG00000018563|UniProtKB=F6YMF6	Uncharacterized protein	ISS			PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P00036	Interleukin signaling pathway	P00981	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00046	Oxidative stress response	P01135	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	PANTR|Gene=CHRM3|UniProtKB=Q9N2A4	Muscarinic acetylcholine receptor M3	TAS	10069496	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	IDA	8838325	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P02738	De novo purine biosynthesis	P02904	Guanylate kinase	ARATH|TAIR=AT3G57550|UniProtKB=Q9M682	Guanylate kinase 2	ISS			PTHR23117:SF13	GUANYLATE KINASE
P00057	Wnt signaling pathway	P01443	Phospholipase C	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	CAEEL|WormBase=WBGene00002189|UniProtKB=P21137	cAMP-dependent protein kinase catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P05917	Opioid proopiomelanocortin pathway	P06008	ACTH	RAT|RGD=3366|UniProtKB=P01194	Pro-opiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00049	Parkinson disease	P01211	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01440	Cadherin	BOVIN|Ensembl=ENSBTAG00000015405|UniProtKB=E1B969	Uncharacterized protein	ISS	8120095	PubMed	PTHR43956:SF6	PROTOCADHERIN-16
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DANRE|ZFIN=ZDB-GENE-050417-267|UniProtKB=F1QUN8	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF263	ACTIN
P00055	Transcription regulation by bZIP transcription factor	P01389	TTF2	MOUSE|MGI=MGI=1918240|UniProtKB=Q8CHZ9	Transcription termination factor 1a, mitochondrial	ISS			PTHR15437:SF2	TRANSCRIPTION TERMINATION FACTOR 1, MITOCHONDRIAL
P00005	Angiogenesis	P00226	Delta/Serrate	DANRE|ZFIN=ZDB-GENE-011128-2|UniProtKB=Q90Y57	Protein jagged-1a	ISS			PTHR44097:SF3	PROTEIN JAGGED-1
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	ANOGA|Gene=AgaP_AGAP009443|UniProtKB=Q5TXC3	AGAP009443-PA (Fragment)	ISS	96032356	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-8225|UniProtKB=Q7SZZ5	Uncharacterized protein	ISS			PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04397	p53 pathway by glucose deprivation	P04641	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	RCA	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00590	IP3 R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BRAFL|Gene=BRAFLDRAFT_56711|UniProtKB=C3XPR5	Protein Wnt	TAS	8717036	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	HUMAN|HGNC=667|UniProtKB=P61586	Transforming protein RhoA	ISS	12169092	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	RCA	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	CAEEL|WormBase=WBGene00002196|UniProtKB=P28548	Casein kinase II subunit beta	IDA	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02728	Arginine biosynthesis	P02841	argininosuccinate lyase	ECOLI|EcoGene=EG11223|UniProtKB=P11447	Argininosuccinate lyase	ISS			PTHR43814:SF1	ARGININOSUCCINATE LYASE
P00021	FGF signaling pathway	P00633	Ras	NEUCR|EnsemblGenome=EFNCRG00000008769|UniProtKB=P22126	Protein ras-1	ISS	7997267	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	MACMU|Ensembl=ENSMMUG00000010184|UniProtKB=F6SR09	Uncharacterized protein	ISS	14614461	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IDA	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05731	GABA-B receptor II signaling	P05755	Gbeta	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00006	Apoptosis signaling pathway	P00260	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00398	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000023940|UniProtKB=F6RFW8	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00057	Wnt signaling pathway	P01448	CBP	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P02746	Heme biosynthesis	P02981	Glutamate-1-semialdehyde aminotransferase	AQUAE|EnsemblGenome=aq_816|UniProtKB=O66998	Glutamate-1-semialdehyde 2,1-aminomutase	ISS			PTHR43713:SF3	GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	ISS	11554549	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00056	VEGF signaling pathway	P01402	MEK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS			PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00947	Laminin	PANTR|Ensembl=ENSPTRG00000009922|UniProtKB=H2QEC7	Laminin, alpha 3	ISS	2538453	PubMed	PTHR10574:SF285	LAMININ SUBUNIT ALPHA-3
P00010	B cell activation	P00381	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	IGI	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P05734	Synaptic vesicle trafficking	P05778	SNAP-25	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00643	Raf-1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00045	Notch signaling pathway	P01101	Su(H)	BOVIN|Ensembl=ENSBTAG00000003602|UniProtKB=Q3SZ41	Recombining binding protein suppressor of hairless	ISS	12145413	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00019	Endothelin signaling pathway	P00591	PLCbeta	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	RAT|RGD=621705|UniProtKB=Q8VHN2	Glutamate receptor ionotropic, NMDA 3B	IC	14698601	PubMed	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P00006	Apoptosis signaling pathway	P00260	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00051	TCA cycle	P01274	Succinyl CoA Synthetase	PSEAE|EnsemblGenome=PA1589|UniProtKB=Q51567	Succinyl-CoA ligase [ADP-forming] subunit alpha	ISS	21534948	PubMed	PTHR11117:SF11	SUCCINYL-COA LIGASE  ADP-FORMING  SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00006	Apoptosis signaling pathway	P00280	PACT	MACMU|Ensembl=ENSMMUG00000002185|UniProtKB=F6WMP8	Interferon-inducible double stranded RNA-dependent protein kinase activator A isoform 1	ISS			PTHR10910:SF8	INTERFERON-INDUCIBLE DOUBLE-STRANDED RNA-DEPENDENT PROTEIN KINASE ACTIVATOR A
P00029	Huntington disease	P00807	Actin	CHICK|Ensembl=ENSGALG00000011086|UniProtKB=P68139	Actin, alpha skeletal muscle	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	RAT|RGD=1559756|UniProtKB=F1M280	Metalloendopeptidase	ISS	9759503	PubMed	PTHR43978:SF1	TOLLOID-LIKE PROTEIN 2
P05913	Enkephalin release	P05974	G-Protein (i)	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04393	Ras Pathway	P04542	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CHICK|Ensembl=ENSGALG00000011809|UniProtKB=F1NMB0	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00021	FGF signaling pathway	P00642	MEK1-2	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00034	Integrin signalling pathway	P00922	Collagen	BOVIN|Ensembl=ENSBTAG00000013662|UniProtKB=A7E303	COL8A1 protein	ISS	10778855	PubMed	PTHR44057:SF2	COLLAGEN ALPHA-1 VIII  CHAIN
P00012	Cadherin signaling pathway	P00470	F-actin	PUCGT|EnsemblGenome=PGTG_05488|UniProtKB=E3K4I1	Actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	BOVIN|Ensembl=ENSBTAG00000040439|UniProtKB=F6Q2H9	Uncharacterized protein	ISS	12181435	PubMed	PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00563	Gab	BOVIN|Ensembl=ENSBTAG00000002813|UniProtKB=A6QLU3	GRB2-associated-binding protein 1	ISS	15356145	PubMed	PTHR12156:SF18	GRB2-ASSOCIATED-BINDING PROTEIN 1
P05731	GABA-B receptor II signaling	P05752	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	CANLF|Ensembl=ENSCAFG00000011625|UniProtKB=F1PDD9	Uncharacterized protein	ISS	12787506	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00591	PLCbeta	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	HUMAN|HGNC=132|UniProtKB=P60709	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00005	Angiogenesis	P00235	c-Fos	MONDO|Ensembl=ENSMODG00000005927|UniProtKB=F6WX28	Uncharacterized protein	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00059	p53 pathway	P04633	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	TAKRU|Ensembl=ENSTRUG00000011517|UniProtKB=H2TWL9	Uncharacterized protein (Fragment)	ISS	12871085	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02918	dUTP pyrophosphatase	SCHPO|PomBase=SPAC644.05c|UniProtKB=Q9P6Q5	Probable deoxyuridine 5'-triphosphate nucleotidohydrolase	ISS			PTHR11241:SF0	BCDNA.LD08534
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CRYNJ|EnsemblGenome=CND03830|UniProtKB=Q5KI86	Uncharacterized protein	IC	10594037	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00006	Apoptosis signaling pathway	P00321	HSP70	ARATH|TAIR=AT3G09440|UniProtKB=O65719	Heat shock 70 kDa protein 3	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00021	FGF signaling pathway	P00623	FGF	MOUSE|MGI=MGI=95520|UniProtKB=P21658	Fibroblast growth factor 6	ISS	11801566	PubMed	PTHR11486:SF25	FIBROBLAST GROWTH FACTOR 6
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	MONDO|Ensembl=ENSMODG00000009937|UniProtKB=F6R812	Uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	P01443	Phospholipase C	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00021	FGF signaling pathway	P00624	14-3-3	PANTR|Ensembl=ENSPTRG00000008521|UniProtKB=G2HI54	14-3-3 protein epsilon	ISS	98119747	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00007	Axon guidance mediated by semaphorins	P00340	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12874273	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MOUSE|MGI=MGI=95819|UniProtKB=P35438	Glutamate receptor ionotropic, NMDA 1	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00010	B cell activation	P00371	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00047	PDGF signaling pathway	P01175	Shc	MACMU|Ensembl=ENSMMUG00000020357|UniProtKB=F6W915	SHC-transforming protein 3	ISS	9507002	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00311	GCKR	MOUSE|MGI=MGI=1349394|UniProtKB=P97820	Mitogen-activated protein kinase kinase kinase kinase 4	RCA			PTHR24361:SF225	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 4
P00057	Wnt signaling pathway	P01446	Calcineurin	PANTR|Ensembl=ENSPTRG00000016315|UniProtKB=H2QPY6	Serine/threonine-protein phosphatase	ISS	7532676	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00807	Actin	HUMAN|HGNC=129|UniProtKB=P68133	Actin, alpha skeletal muscle	IDA	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CHICK|Ensembl=ENSGALG00000004790|UniProtKB=P49337	Protein Wnt-4	TAS	8717036	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00053	T cell activation	P01332	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02783	Tryptophan biosynthesis	P03206	Anthranilate synthase	METJA|EnsemblGenome=MJ_1075|UniProtKB=Q58475	Anthranilate synthase component 1	ISS			PTHR11236:SF9	ANTHRANILATE SYNTHASE COMPONENT 1
P02735	Cobalamin biosynthesis	P02881	Ribazole-5-phosphate phosphatase	ECOLI|EcoGene=EG13240|UniProtKB=P52086	Adenosylcobalamin/alpha-ribazole phosphatase	RCA			PTHR23029:SF56	PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN
P00010	B cell activation	P00391	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	BOVIN|Ensembl=ENSBTAG00000004281|UniProtKB=F1MQX0	Acetyl-coenzyme A synthetase	ISS			PTHR24095:SF110	ACETYL-COENZYME A SYNTHETASE 2-LIKE, MITOCHONDRIAL
P05913	Enkephalin release	P05971	CREB	BOVIN|Gene=CREB1|UniProtKB=P27925	Cyclic AMP-responsive element-binding protein 1	ISS	11390664	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	MOUSE|MGI=MGI=97355|UniProtKB=P15532	Nucleoside diphosphate kinase A	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P00057	Wnt signaling pathway	P01452	NFAT	PANTR|Ensembl=ENSPTRG00000006218|UniProtKB=H2Q834	Uncharacterized protein	ISS	12787506	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01188	Gbetagamma	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	9754712	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00021	FGF signaling pathway	P00627	ERK1-2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	DAPPU|EnsemblGenome=DAPPUDRAFT_300845|UniProtKB=E9HEX5	Putative uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF250	SUBFAMILY NOT NAMED
P00013	Cell cycle	P00480	Proteasome	HUMAN|HGNC=9570|UniProtKB=P61289	Proteasome activator complex subunit 3	ISS	9218537	PubMed	PTHR10660:SF4	PROTEASOME ACTIVATOR COMPLEX SUBUNIT 3
P00034	Integrin signalling pathway	P00936	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	IPI	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P00012	Cadherin signaling pathway	P00471	Cadherin	BOVIN|Gene=CDHR1|UniProtKB=Q8WN91	Cadherin-related family member 1	IDA	8120095	PubMed	PTHR44506:SF1	CADHERIN-RELATED FAMILY MEMBER 1
P00045	Notch signaling pathway	P01101	Su(H)	TAKRU|Ensembl=ENSTRUG00000014798|UniProtKB=H2ULI5	Uncharacterized protein	ISS	9043084	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P05731	GABA-B receptor II signaling	P05754	Ggamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	RCA	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00046	Oxidative stress response	P01129	JNK1/2	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IC	94179345	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P04393	Ras Pathway	P04555	PDK	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00021	FGF signaling pathway	P00628	JNK1-3	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00183	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	10982827	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	ORNAN|Ensembl=ENSOANG00000010907|UniProtKB=F6ZLV0	Inosine-5'-monophosphate dehydrogenase	ISS			PTHR11911:SF121	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2
P04393	Ras Pathway	P04552	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IDA	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00540	MKK3,6	MONDO|Ensembl=ENSMODG00000006330|UniProtKB=F7AGV5	Uncharacterized protein	ISS	8622669	PubMed	PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	ANOGA|EnsemblGenome=AGAP010172|UniProtKB=Q7PD38	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P06587	Nicotine pharmacodynamics pathway	P06593	CHRNA5	RAT|RGD=2347|UniProtKB=P20420	Neuronal acetylcholine receptor subunit alpha-5	IDA	12388584	PubMed	PTHR18945:SF76	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5
P04384	Gamma-aminobutyric acid synthesis	P04481	Succinic semialdehyde dehydrogenase	YEAST|SGD=S000000210|UniProtKB=P38067	Succinate-semialdehyde dehydrogenase [NADP(+)]	IC	12891648	PubMed	PTHR43353:SF5	SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL
P00059	p53 pathway	G01579	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P06959	CCKR signaling map	P07029	CNKSR1	HUMAN|HGNC=19700|UniProtKB=Q969H4	Connector enhancer of kinase suppressor of ras 1	RCA	11237210	PubMed	PTHR12844:SF10	CONNECTOR ENHANCER OF KINASE SUPPRESSOR OF RAS 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05913	Enkephalin release	P05972	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	11956331	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ARATH|TAIR=AT1G60490|UniProtKB=P42339	Phosphatidylinositol 3-kinase VPS34	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00025	Hedgehog signaling pathway	P00682	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05939	GRK6	CANLF|Ensembl=ENSCAFG00000016388|UniProtKB=F6X9W7	Protein-serine/threonine kinase	ISS	12032308	PubMed	PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	ARATH|TAIR=AT3G43810|UniProtKB=P59220	Calmodulin-7	ISS	7514101	PubMed	PTHR23050:SF250	CALMODULIN-7
P00010	B cell activation	P00376	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00005	Angiogenesis	P00238	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00036	Interleukin signaling pathway	P00990	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P05913	Enkephalin release	P05974	G-Protein (i)	XENTR|Xenbase=XB-GENE-977853|UniProtKB=F7EBE7	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MOUSE|MGI=MGI=87909|UniProtKB=P62737	Actin, aortic smooth muscle	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00059	p53 pathway	P01486	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12539654	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00025	Hedgehog signaling pathway	P00692	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00029	Huntington disease	P00776	c-Jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Gene=OPRM1|UniProtKB=P79350	Mu-type opioid receptor	IDA	11259498	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00805	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01412	HSP27	BOVIN|Ensembl=ENSBTAG00000000434|UniProtKB=P02510	Alpha-crystallin B chain	ISS			PTHR11527:SF37	ALPHA-CRYSTALLIN B CHAIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00059	p53 pathway	G04694	p110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00018	EGF receptor signaling pathway	P00564	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00018	EGF receptor signaling pathway	P00558	SOS	DICDI|dictyBase=DDB_G0290901|UniProtKB=Q54FF3	Ras guanine nucleotide exchange factor K	NAS			PTHR23113:SF210	RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR K
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00004	Alzheimer disease-presenilin pathway	P00117	E-cadherin C-terminal fragment	RAT|RGD=69279|UniProtKB=Q9R0T4	Cadherin-1	IDA	12834808	PubMed	PTHR24027:SF319	CADHERIN-1
P00024	Glycolysis	P00675	Pyruvate kinase	HUMAN|HGNC=9021|UniProtKB=P14618	Pyruvate kinase PKM	RCA			PTHR11817:SF15	PYRUVATE KINASE PKM
P00054	Toll receptor signaling pathway	P01342	IRAK4	MOUSE|MGI=MGI=2182474|UniProtKB=Q8R4K2	Interleukin-1 receptor-associated kinase 4	ISS			PTHR24419:SF22	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	CAEBR|Gene=CBG12631|UniProtKB=A8XG73	Protein CBR-RAB-10	ISS			PTHR24073:SF316	IP08727P-RELATED
P06664	Gonadotropin-releasing hormone receptor pathway	P06739	MEK1/2	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	RCA	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	9395335	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00018	EGF receptor signaling pathway	P00551	Akt	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	IGI	12655147	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CAEEL|WormBase=WBGene00004036|UniProtKB=G5EFI8	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00021	FGF signaling pathway	P00638	PLCgamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	IDA	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00029	Huntington disease	P00807	Actin	XENTR|Xenbase=XB-GENE-491618|UniProtKB=Q6P378	Actin, cytoplasmic 2	ISS	3487386	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	CAEEL|WormBase=WBGene00001623|UniProtKB=O18210	Amino acid transporter	IC			PTHR11958:SF45	AMINO ACID TRANSPORTER
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	3755548	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	TAKRU|Ensembl=ENSTRUG00000015959|UniProtKB=H2UV27	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00006	Apoptosis signaling pathway	P00269	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00034	Integrin signalling pathway	P00916	Ras	DROME|FlyBase=FBgn0003205|UniProtKB=P08646	Ras-like protein 1	IPI	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P05918	p38 MAPK pathway	P06029	p38beta	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	CHICK|Ensembl=ENSGALG00000000951|UniProtKB=Q90826	C-C motif chemokine 4 homolog	ISS			PTHR12015:SF103	C-C MOTIF CHEMOKINE 4-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00203	Erk	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00275	Bak	RAT|RGD=621635|UniProtKB=Q9JK59	BAK protein	ISS	11278671	PubMed	PTHR11256:SF41	BCL-2 HOMOLOGOUS ANTAGONIST/KILLER
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000025373|UniProtKB=F6ZZG9	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00029	Huntington disease	P00807	Actin	CHICK|Ensembl=ENSGALG00000028749|UniProtKB=Q5ZMQ2	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	DANRE|ZFIN=ZDB-GENE-000502-1|UniProtKB=Q1RLX1	Receptor protein serine/threonine kinase	TAS	10683140	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	HUMAN|HGNC=232|UniProtKB=Q08828	Adenylate cyclase type 1	ISS	89298382	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CHICK|Ensembl=ENSGALG00000009640|UniProtKB=F1P0I0	Muscarinic acetylcholine receptor	IDA	12181435	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	MYCTU|EnsemblGenome=LH57_20445|UniProtKB=O69719	tRNA-specific adenosine deaminase	ISS			PTHR11079:SF149	TRNA-SPECIFIC ADENOSINE DEAMINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00054	Toll receptor signaling pathway	P01375	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00049	Parkinson disease	P01242	Casein kinase I	HUMAN|HGNC=2456|UniProtKB=Q9Y6M4	Casein kinase I isoform gamma-3	IDA	11437445	PubMed	PTHR11909:SF151	CASEIN KINASE I ISOFORM GAMMA-3
P00018	EGF receptor signaling pathway	P00552	Ras	CHICK|Ensembl=ENSGALG00000011592|UniProtKB=Q6JHX4	R-Ras3	ISS			PTHR24070:SF268	RAS-RELATED PROTEIN M-RAS
P00034	Integrin signalling pathway	P00907	ERK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	ISS			PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00049	Parkinson disease	P01213	Cyclin E	RAT|RGD=2294|UniProtKB=P39949	G1/S-specific cyclin-E1	IDA	15705141	gi	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00012	Cadherin signaling pathway	P00468	Src	MACMU|Ensembl=ENSMMUG00000020131|UniProtKB=F7FWN4	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00057	Wnt signaling pathway	P01448	CBP	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P05916	Opioid prodynorphin pathway	P06000	vasopressin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P02738	De novo purine biosynthesis	P02894	IMP cyclohydrolase	ANOGA|EnsemblGenome=AGAP001423|UniProtKB=Q7PXI8	AGAP001423-PA	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P00059	p53 pathway	G04696	Siah	BOVIN|Ensembl=ENSBTAG00000010868|UniProtKB=F1N5G3	E3 ubiquitin-protein ligase	ISS	14985507	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	91298951	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00183	Shc	MOUSE|MGI=MGI=98296|UniProtKB=P98083	SHC-transforming protein 1	ISS	95096035	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	RAT|RGD=2347|UniProtKB=P20420	Neuronal acetylcholine receptor subunit alpha-5	ISS	12388584	PubMed	PTHR18945:SF76	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5
P04393	Ras Pathway	P04558	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	HUMAN|HGNC=4597|UniProtKB=P41594	Metabotropic glutamate receptor 5	ISS	8314195	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00019	Endothelin signaling pathway	P00570	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-070112-342|UniProtKB=A1L271	Uncharacterized protein	ISS	10051575	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00009	Axon guidance mediated by netrin	P00359	NFAT	HUMAN|HGNC=7777|UniProtKB=Q12968	Nuclear factor of activated T-cells, cytoplasmic 3	IDA	12787506	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00053	T cell activation	P01306	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00035	Interferon-gamma signaling pathway	P00960	PTP	CANLF|Ensembl=ENSCAFG00000008894|UniProtKB=F1Q3J6	Tyrosine-protein phosphatase non-receptor type	ISS	14534538	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00018	EGF receptor signaling pathway	P00545	JNK1-3	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	METAC|EnsemblGenome=MA_3382|UniProtKB=Q8TKM1	Glutamate-ammonia ligase	ISS			PTHR43407:SF1	LENGSIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MOUSE|MGI=MGI=87905|UniProtKB=P68033	Actin, alpha cardiac muscle 1	IC	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P02772	Pyruvate metabolism	P03137	Citrate Lyase	PANTR|Ensembl=ENSPTRG00000005998|UniProtKB=H2R0Q3	Uncharacterized protein	ISS			PTHR11105:SF0	CITRATE LYASE SUBUNIT BETA-LIKE PROTEIN, MITOCHONDRIAL
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	MOUSE|MGI=MGI=1859545|UniProtKB=Q9R0N7	Synaptotagmin-7	RCA			PTHR10024:SF344	SYNAPTOTAGMIN-7
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1203729|UniProtKB=Q61194	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P02772	Pyruvate metabolism	P03135	Phosphoenolpyruvate Carboxykinase	CANLF|Ensembl=ENSCAFG00000012065|UniProtKB=F1PAM0	Uncharacterized protein	ISS	8325643	PubMed	PTHR11561:SF1	PHOSPHOENOLPYRUVATE CARBOXYKINASE, CYTOSOLIC  GTP
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00965	ERK	CANLF|Ensembl=ENSCAFG00000015640|UniProtKB=E2QVF3	Uncharacterized protein	ISS	8444355	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	MACMU|Ensembl=ENSMMUG00000021442|UniProtKB=F7EAQ8	Muscarinic acetylcholine receptor	ISS	12915051	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00006	Apoptosis signaling pathway	P00305	Caspase 3	HUMAN|HGNC=1504|UniProtKB=P42574	Caspase-3	IDA	9323209	PubMed	PTHR10454:SF198	CASPASE-3
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00775	Rac	CAEBR|Gene=CBG17302|UniProtKB=A8XQS8	Protein CBR-MIG-2	ISS			PTHR24072:SF157	AT17867P
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00021	FGF signaling pathway	P00629	PP2A	CANLF|Ensembl=ENSCAFG00000015787|UniProtKB=F6V7D9	Uncharacterized protein	ISS	8703017	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	MOUSE|MGI=MGI=104589|UniProtKB=P63268	Actin, gamma-enteric smooth muscle	IC	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IGI	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00006	Apoptosis signaling pathway	P00286	AIF	MOUSE|MGI=MGI=1349419|UniProtKB=Q9Z0X1	Apoptosis-inducing factor 1, mitochondrial	IDA	9989411	PubMed	PTHR43557:SF4	APOPTOSIS-INDUCING FACTOR 1, MITOCHONDRIAL
P00049	Parkinson disease	P01232	CASK	HUMAN|HGNC=1497|UniProtKB=O14936	Peripheral plasma membrane protein CASK	IPI	11430913	PubMed	PTHR23122:SF40	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	DROME|FlyBase=FBgn0001991|UniProtKB=Q24270	Voltage-dependent calcium channel type D subunit alpha-1	ISS	15621031	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	RCA	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	NAS	9851932	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	PANTR|Ensembl=ENSPTRG00000003795|UniProtKB=H2Q3X5	Muscarinic acetylcholine receptor	ISS	12915051	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05918	p38 MAPK pathway	P06018	MNK1	RAT|RGD=1559603|UniProtKB=Q4G050	MAP kinase-interacting serine/threonine-protein kinase 1	ISS	97299868	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00046	Oxidative stress response	P01135	p38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P06587	Nicotine pharmacodynamics pathway	P06605	KCNK3/9	MOUSE|MGI=MGI=1100509|UniProtKB=O35111	Potassium channel subfamily K member 3	RCA	15282272	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00977	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000005917|UniProtKB=F6QM53	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04376	5HT4 type receptor mediated signaling pathway	P04431	5HT transporter	RAT|RGD=3714|UniProtKB=P31652	Sodium-dependent serotonin transporter	ISS	14653308	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	ARATH|TAIR=AT1G73670|UniProtKB=Q9C9U4	Mitogen-activated protein kinase 15	TAS			PTHR24055:SF246	MITOGEN-ACTIVATED PROTEIN KINASE 15-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05915	Opioid proenkephalin pathway	P05994	G-protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04393	Ras Pathway	P04559	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	10891487	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00020	FAS signaling pathway	P00611	Gelsolin	CANLF|Ensembl=ENSCAFG00000007788|UniProtKB=E2R413	Uncharacterized protein	ISS	9323209	PubMed	PTHR11977:SF13	MACROPHAGE-CAPPING PROTEIN
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BOVIN|Gene=ACTG2|UniProtKB=Q5E9B5	Actin, gamma-enteric smooth muscle	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PRIPA|Gene=PPA23459|UniProtKB=H3FMF2	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	RAT|RGD=628837|UniProtKB=P60711	Actin, cytoplasmic 1	IC	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MOUSE|MGI=MGI=88399|UniProtKB=P32211	Muscarinic acetylcholine receptor M4	TAS	8100450	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00036	Interleukin signaling pathway	P00996	STAT	RAT|RGD=1309063|UniProtKB=Q1KQ07	Signal transducer and activator of transcription	ISS	14598258	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00034	Integrin signalling pathway	P00948	Rho	CHICK|Ensembl=ENSGALG00000016485|UniProtKB=O93468	GTP-binding protein	ISS	13679859	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	SCHPO|PomBase=SPAC227.09|UniProtKB=Q9UTD0	Probable dihydrofolate synthetase	ISS			PTHR11136:SF0	DIHYDROFOLATE SYNTHETASE-RELATED
P00034	Integrin signalling pathway	P00923	Arf1	RAT|RGD=621270|UniProtKB=P84079	ADP-ribosylation factor 1	ISS	11752622	PubMed	PTHR11711:SF234	ADP-RIBOSYLATION FACTOR 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00052	TGF-beta signaling pathway	P01292	RSmads	ORNAN|Ensembl=ENSOANG00000015497|UniProtKB=F6Y0Z8	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF41	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 9
P06959	CCKR signaling map	G07273	HuR	HUMAN|HGNC=3312|UniProtKB=Q15717	ELAV-like protein 1	RCA	18395088	PubMed	PTHR43938:SF4	ELAV-LIKE PROTEIN 1
P04398	p53 pathway feedback loops 2	P04664	cyclin E	STRPU|EnsemblGenome=SPU_001712|UniProtKB=W4XEA0	Uncharacterized protein	ISS	98112190	PubMed	PTHR10177:SF344	G1/S-SPECIFIC CYCLIN-E
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00015	Circadian clock system	G01497	cry	BOVIN|Ensembl=ENSBTAG00000021223|UniProtKB=F1N0J9	Uncharacterized protein	ISS	10428031	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	ANOGA|EnsemblGenome=AGAP010267|UniProtKB=Q7Q0M3	AGAP010267-PA	ISS			PTHR43097:SF4	GLUTAMINE--TRNA LIGASE-RELATED
P00047	PDGF signaling pathway	P01148	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	7689150	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00057	Wnt signaling pathway	P01466	Diversin	HUMAN|HGNC=17280|UniProtKB=Q9Y2G4	Ankyrin repeat domain-containing protein 6	ISS	12183362	PubMed	PTHR24203:SF7	ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 6
P04397	p53 pathway by glucose deprivation	P04639	AMPK	ORNAN|Ensembl=ENSOANG00000004087|UniProtKB=F6YST6	Uncharacterized protein	ISS			PTHR24343:SF306	5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00803	Sp1	HUMAN|HGNC=11205|UniProtKB=P08047	Transcription factor Sp1	RCA			PTHR23235:SF16	TRANSCRIPTION FACTOR SP1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=97439|UniProtKB=P33534	Kappa-type opioid receptor	IDA	11259487	PubMed	PTHR24229:SF1	KAPPA-TYPE OPIOID RECEPTOR
P02738	De novo purine biosynthesis	P02891	GDP kinase	PANTR|Ensembl=ENSPTRG00000009415|UniProtKB=H2QDG2	Nucleoside diphosphate kinase	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P05917	Opioid proopiomelanocortin pathway	P06011	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04397	p53 pathway by glucose deprivation	P04641	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05915	Opioid proenkephalin pathway	P05992	met-Enkephalin	PANTR|Ensembl=ENSPTRG00000020270|UniProtKB=H2QW70	Proenkephalin	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	RAT|RGD=620351|UniProtKB=P18265	Glycogen synthase kinase-3 alpha	IDA	14698990	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00056	VEGF signaling pathway	P01417	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MOUSE|MGI=MGI=87912|UniProtKB=P27040	Activin receptor type-2B	TAS	11252892	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01211	ERK	LEIMA|EnsemblGenome=LmjF.36.6470|UniProtKB=Q4Q0B0	Mitogen-activated protein kinase	ISS			PTHR24055:SF178	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00223	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00274	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=1921305|UniProtKB=Q8K4S1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	10934033	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00053	T cell activation	P01332	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=98953|UniProtKB=P04426	Proto-oncogene Wnt-1	IDA	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02755	Methylmalonyl pathway	P03033	Propionyl-CoA carboxylase	HUMAN|HGNC=8654|UniProtKB=P05166	Propionyl-CoA carboxylase beta chain, mitochondrial	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P00003	Alzheimer disease-amyloid secretase pathway	P00107	kinesin	HUMAN|HGNC=6387|UniProtKB=Q07866	Kinesin light chain 1	IDA	11740561	PubMed	PTHR19959:SF203	KINESIN LIGHT CHAIN 1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00642	MEK1-2	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	CANLF|Ensembl=ENSCAFG00000012923|UniProtKB=F1PEK4	Uncharacterized protein	ISS			PTHR44107:SF3	DOWN SYNDROME CELL ADHESION MOLECULE-LIKE PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	TRIAD|EnsemblGenome=TriadG35956|UniProtKB=Q7YTV5	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02738	De novo purine biosynthesis	P02894	IMP cyclohydrolase	SCHPO|PomBase=SPCPB16A4.03c|UniProtKB=O74928	Bifunctional purine biosynthesis protein ade10	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P00019	Endothelin signaling pathway	P00572	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P02762	Pentose phosphate pathway	P03081	Transaldolase	THEMA|EnsemblGenome=TM_0295|UniProtKB=Q9WYD1	Transaldolase	IEA			PTHR10683:SF18	TRANSALDOLASE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00017	DNA replication	P00527	Histones	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g196043|UniProtKB=A7TCQ6	Histone H3	ISS	12413958	PubMed	PTHR11426:SF20	HISTONE H3-LIKE CENTROMERIC PROTEIN A
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	6264430	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00018	EGF receptor signaling pathway	P00564	Rac	ARATH|TAIR=AT4G28950|UniProtKB=O82480	Rac-like GTP-binding protein ARAC7	ISS	12932731	PubMed	PTHR24072:SF127	RAC-LIKE GTP-BINDING PROTEIN ARAC7
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	11591316	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	HUMAN|HGNC=16767|UniProtKB=Q8TCU5	Glutamate receptor ionotropic, NMDA 3A	ISS	11319238	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00057	Wnt signaling pathway	P01437	TCF	CHICK|Ensembl=ENSGALG00000010529|UniProtKB=O93345	Lymphiod enhancer binding factor 1	IDA	9039917	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00018	EGF receptor signaling pathway	P00564	Rac	DICDI|dictyBase=DDB_G0277869|UniProtKB=P34144	Rho-related protein rac1A	IGI	4757952	gi	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00019	Endothelin signaling pathway	P00589	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01465	Ggamma	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00006	Apoptosis signaling pathway	P00310	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	DANRE|ZFIN=ZDB-GENE-980526-527|UniProtKB=B3DJ37	Receptor protein serine/threonine kinase	TAS	9395284	PubMed	PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MOUSE|MGI=MGI=87904|UniProtKB=P60710	Actin, cytoplasmic 1	IDA	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P02723	Adenine and hypoxanthine salvage pathway	P02810	Adenine phosphoribosyl transferase	DEIRA|EnsemblGenome=DR_1617|UniProtKB=Q9RTY2	Xanthine phosphoribosyltransferase	ISS			PTHR43864:SF1	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00238	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	IDA	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00006	Apoptosis signaling pathway	P00268	GCK	MOUSE|MGI=MGI=1346883|UniProtKB=Q61161	Mitogen-activated protein kinase kinase kinase kinase 2	ISS			PTHR24361:SF392	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 2
P00059	p53 pathway	P04611	P300	MOUSE|MGI=MGI=1276116|UniProtKB=B2RWS6	Histone acetyltransferase p300	ISS	10664585	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00590	IP3 R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P06664	Gonadotropin-releasing hormone receptor pathway	G06887	EGR1	MOUSE|MGI=MGI=95295|UniProtKB=P08046	Early growth response protein 1	RCA			PTHR44685:SF1	EARLY GROWTH RESPONSE PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04586	ProTRH (Pro Thyrotropin-releasing Hormone)	RAT|RGD=620436|UniProtKB=P11962	Glycoprotein hormones alpha chain	ISS			PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P00053	T cell activation	P01295	vav	PANTR|Ensembl=ENSPTRG00000010378|UniProtKB=H2QF58	Uncharacterized protein	ISS	10661401	PubMed	PTHR22826:SF112	PROTO-ONCOGENE VAV
P00036	Interleukin signaling pathway	P00970	Interleukin	BOVIN|Ensembl=ENSBTAG00000014921|UniProtKB=P26892	Interleukin-6	IC			PTHR45110:SF1	INTERLEUKIN-6
P00036	Interleukin signaling pathway	P00967	c-fos	RAT|RGD=2626|UniProtKB=P12841	Proto-oncogene c-Fos	TAS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00018	EGF receptor signaling pathway	P00543	ERK1-2	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01323	I kappa B	MOUSE|MGI=MGI=104741|UniProtKB=Q9Z1E3	NF-kappa-B inhibitor alpha	ISS	10869418	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00006	Apoptosis signaling pathway	P00260	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=1298406|UniProtKB=O88689	Protocadherin alpha-4	IDA	8120095	PubMed	PTHR24028:SF82	PROTOCADHERIN ALPHA-4
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00010	B cell activation	P00385	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00029	Huntington disease	P00796	Kainate receptor	XENTR|Xenbase=XB-GENE-957124|UniProtKB=F7BDN8	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00049	Parkinson disease	P01208	Hsp70	TETTS|EnsemblGenome=TTHERM_01044390|UniProtKB=Q22CG9	Heat shock 70 kDa protein	IDA	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00005	Angiogenesis	P00206	Wnt	BOVIN|Ensembl=ENSBTAG00000014291|UniProtKB=A6H6X8	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	DROME|FlyBase=FBgn0263116|UniProtKB=P28286	5-hydroxytryptamine receptor 2B	IDA			PTHR24247:SF117	5-HYDROXYTRYPTAMINE RECEPTOR 2A-RELATED
P05918	p38 MAPK pathway	P06035	TAB1	PANTR|Ensembl=ENSPTRG00000014395|UniProtKB=H2QLQ4	Uncharacterized protein	ISS	10838074	PubMed	PTHR13832:SF533	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00570	PKA	STRPU|EnsemblGenome=SPU_018419|UniProtKB=W4YRI6	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00023	General transcription regulation	P00658	TBP-associated factors	MONDO|Ensembl=ENSMODG00000012785|UniProtKB=F6S0M5	Uncharacterized protein	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	RAT|RGD=1560525|UniProtKB=Q498S8	Frizzled-8	ISS	11212302	PubMed	PTHR11309:SF90	FRIZZLED-8
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	11204774	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00047	PDGF signaling pathway	P01142	p90RSK	HUMAN|HGNC=10430|UniProtKB=Q15418	Ribosomal protein S6 kinase alpha-1	ISS	15226426	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	CAEEL|WormBase=WBGene00006577|UniProtKB=B2D6P4	TBP-Like Factor	ISS	600075	OMIM	PTHR10126:SF13	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000000289|UniProtKB=F7A9T0	Uncharacterized protein	ISS	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	ANOGA|EnsemblGenome=AGAP002570|UniProtKB=Q7QCD2	AGAP002570-PA	ISS			PTHR43311:SF2	GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PHYPA|Gene=PHYPADRAFT_172686|UniProtKB=A9TYG6	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	MOUSE|MGI=MGI=1351342|UniProtKB=Q3UVX5	Metabotropic glutamate receptor 5	ISS	9407094	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00017	DNA replication	P00532	Hel	ARATH|TAIR=AT1G60930|UniProtKB=Q9FT70	ATP-dependent DNA helicase Q-like 4B	TAS	11121451	gi	PTHR13710:SF105	BLOOM SYNDROME PROTEIN
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	PANTR|Ensembl=ENSPTRG00000011296|UniProtKB=H2QGV0	Aldehyde dehydrogenase 16 family, member A1	ISS			PTHR11699:SF98	ALDEHYDE DEHYDROGENASE FAMILY 16 MEMBER A1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05916	Opioid prodynorphin pathway	P05999	provasopressin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	MONDO|Ensembl=ENSMODG00000015246|UniProtKB=F6UJF5	Uncharacterized protein	ISS	11431030	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	MACMU|Ensembl=ENSMMUG00000015916|UniProtKB=F7AT89	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF401	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	BOVIN|Ensembl=ENSBTAG00000018445|UniProtKB=E1BK87	Uncharacterized protein	ISS	11319238	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00029	Huntington disease	P00786	ARF	TAKRU|Ensembl=ENSTRUG00000014335|UniProtKB=H2UI79	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF294	ADP-RIBOSYLATION FACTOR 3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P02774	Salvage pyrimidine deoxyribonucleotides	P03148	Thymidine phosphorylase	DEIRA|EnsemblGenome=DR_0443|UniProtKB=Q9RX72	Pyrimidine-nucleoside phosphorylase	ISS	10567266	PubMed	PTHR10515:SF0	THYMIDINE PHOSPHORYLASE
P00036	Interleukin signaling pathway	P00964	p90RSK	HUMAN|HGNC=10431|UniProtKB=Q15349	Ribosomal protein S6 kinase alpha-2	IC	1922062	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	XENTR|Xenbase=XB-GENE-1031985|UniProtKB=Q6GL68	Transcription factor 7-like 1	ISS	12356903	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	XENTR|Xenbase=XB-GENE-1005779|UniProtKB=F7E3I6	Uncharacterized protein	ISS	2039532	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00010	B cell activation	P00384	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	IDA	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	G04714	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	IGI	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	IC	14698601	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00023	General transcription regulation	P00660	RNA Polymerase II	MOUSE|MGI=MGI=1349393|UniProtKB=P61219	DNA-directed RNA polymerases I, II, and III subunit RPABC2	ISS	12841771	gi	PTHR10773:SF12	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2
P00010	B cell activation	P00381	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00790	beta-Tubulin	PANTR|Ensembl=ENSPTRG00000013680|UniProtKB=H2QKN9	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF112	TUBULIN BETA-1 CHAIN
P00034	Integrin signalling pathway	P00925	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	ORNAN|Ensembl=ENSOANG00000006415|UniProtKB=F6WIC7	Uncharacterized protein	ISS	2433589	PubMed	PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P00047	PDGF signaling pathway	P01162	MEK	CAEEL|WormBase=WBGene00003186|UniProtKB=Q10664	Dual specificity mitogen-activated protein kinase kinase mek-2	ISS	17508425	gi	PTHR24361:SF629	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1
P00050	Plasminogen activating cascade	P01243	uPA	MOUSE|MGI=MGI=97611|UniProtKB=P06869	Urokinase-type plasminogen activator	IGI	12376355	PubMed	PTHR24264:SF38	UROKINASE-TYPE PLASMINOGEN ACTIVATOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	BOVIN|Ensembl=ENSBTAG00000003454|UniProtKB=P79348	Regulator of G-protein signaling 20	IDA	8756726	PubMed	PTHR10845:SF175	REGULATOR OF G-PROTEIN SIGNALING 20
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00010	B cell activation	P00381	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IGI	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01125	Stat1	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	TAS	12461178	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00034	Integrin signalling pathway	P00912	Arp2/3	PANTR|Ensembl=ENSPTRG00000001767|UniProtKB=G2HG81	Actin-related protein 2/3 complex subunit 5	ISS	12473693	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	RAT|RGD=67385|UniProtKB=Q8VGC3	Voltage-dependent L-type calcium channel subunit beta-2	IDA	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00047	PDGF signaling pathway	P01150	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	BOVIN|Ensembl=ENSBTAG00000011723|UniProtKB=E1BKL6	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00020	FAS signaling pathway	P00610	MKK4	MONDO|Ensembl=ENSMODG00000008266|UniProtKB=F6Z879	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01092	delta	RAT|RGD=2352|UniProtKB=P25110	Acetylcholine receptor subunit delta	ISS	85203892	PubMed	PTHR18945:SF61	ACETYLCHOLINE RECEPTOR SUBUNIT DELTA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	ORNAN|Ensembl=ENSOANG00000015652|UniProtKB=F7FY70	Uncharacterized protein	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P05731	GABA-B receptor II signaling	P05754	Ggamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	RCA	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=88354|UniProtKB=P09803	Cadherin-1	IDA	11953314	PubMed	PTHR24027:SF319	CADHERIN-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01173	STAT	BOVIN|Ensembl=ENSBTAG00000006335|UniProtKB=F1MGJ4	Signal transducer and activator of transcription	ISS	8085155	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00012	Cadherin signaling pathway	P00474	Wnt	RAT|RGD=621348|UniProtKB=Q9QXQ5	Protein Wnt-4	IDA	11266476	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00034	Integrin signalling pathway	P00936	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00046	Oxidative stress response	P01131	MKP5	SCHPO|PomBase=SPBC17A3.06|UniProtKB=O13632	Tyrosine-protein phosphatase yvh1	ISS			PTHR10159:SF391	SUBFAMILY NOT NAMED
P02785	Valine biosynthesis	P03216	Acetolactate synthase	METAC|EnsemblGenome=MA_1958|UniProtKB=Q8TPF5	Acetolactate synthase	ISS			PTHR18968:SF129	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00567	PKG	PANTR|Ensembl=ENSPTRG00000016212|UniProtKB=H2QPS4	cGMP-dependent protein kinase	ISS	12764134	PubMed	PTHR24353:SF24	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	RAT|RGD=621663|UniProtKB=P19139	Casein kinase II subunit alpha	IDA	10617630	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00021	FGF signaling pathway	P00644	p38	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00018	EGF receptor signaling pathway	P00562	p38	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00010	B cell activation	P00375	Calmodulin	DROME|FlyBase=FBgn0000253|UniProtKB=P62152	Calmodulin	ISS			PTHR23050:SF245	AT16150P-RELATED
P00053	T cell activation	P01322	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00045	Notch signaling pathway	P01110	Presenilin	DANRE|ZFIN=ZDB-GENE-991119-4|UniProtKB=Q9W6T7	Presenilin-1	IGI	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00012	Cadherin signaling pathway	P00470	F-actin	PHYPA|Gene=PHYPADRAFT_225906|UniProtKB=A9TVP1	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04393	Ras Pathway	P04557	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IDA	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00053	T cell activation	P01332	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IDA	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00828	Galphai	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00570	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00543	ERK1-2	ARATH|TAIR=AT1G73670|UniProtKB=Q9C9U4	Mitogen-activated protein kinase 15	ISS			PTHR24055:SF246	MITOGEN-ACTIVATED PROTEIN KINASE 15-RELATED
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00025	Hedgehog signaling pathway	P00682	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02738	De novo purine biosynthesis	P02889	dGDP kinase	ARATH|TAIR=AT4G09320|UniProtKB=P39207	Nucleoside diphosphate kinase 1	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00046	Oxidative stress response	P01127	eEF2K	BOVIN|Ensembl=ENSBTAG00000017662|UniProtKB=E1BEM1	Uncharacterized protein	ISS	11500363	PubMed	PTHR14187:SF56	EUKARYOTIC ELONGATION FACTOR 2 KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01275	P38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	HUMAN|HGNC=706|UniProtKB=O15145	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MONDO|Ensembl=ENSMODG00000024440|UniProtKB=F7DJJ2	Muscarinic acetylcholine receptor	ISS	11166329	PubMed	PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00054	Toll receptor signaling pathway	P01364	TPL2	HUMAN|HGNC=6860|UniProtKB=P41279	Mitogen-activated protein kinase kinase kinase 8	IDA	92019818	PubMed	PTHR24361:SF94	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 8
P04398	p53 pathway feedback loops 2	P04660	SIAH-1	MOUSE|MGI=MGI=108063|UniProtKB=Q06985	E3 ubiquitin-protein ligase SIAH1B	ISS	11389839	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04397	p53 pathway by glucose deprivation	P04640	p53	ORNAN|Ensembl=ENSOANG00000013795|UniProtKB=F7DUR2	Uncharacterized protein (Fragment)	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00021	FGF signaling pathway	P00639	Shc	HUMAN|HGNC=18181|UniProtKB=Q92529	SHC-transforming protein 3	IGI	96404502	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00006	Apoptosis signaling pathway	P00311	GCKR	CANLF|Ensembl=ENSCAFG00000014383|UniProtKB=E2RGP4	Mitogen-activated protein kinase kinase kinase kinase	ISS			PTHR24361:SF324	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 5
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	IDA	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	TAS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00021	FGF signaling pathway	P00623	FGF	DANRE|ZFIN=ZDB-GENE-060506-1|UniProtKB=Q5TKR1	Fibroblast growth factor	ISS			PTHR11486:SF18	FIBROBLAST GROWTH FACTOR 14
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	MOUSE|MGI=MGI=97355|UniProtKB=P15532	Nucleoside diphosphate kinase A	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	TAS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	HUMAN|HGNC=6091|UniProtKB=P06213	Insulin receptor	ISS	2983222	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P02738	De novo purine biosynthesis	P02894	IMP cyclohydrolase	YEAST|SGD=S000004727|UniProtKB=P38009	Bifunctional purine biosynthesis protein ADE17	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P02723	Adenine and hypoxanthine salvage pathway	P02809	Xanthine dehydrogenase	ARATH|TAIR=AT4G34900|UniProtKB=F4JLI5	Xanthine dehydrogenase 2	ISS			PTHR11908:SF100	XANTHINE DEHYDROGENASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=18539|UniProtKB=P61266	Syntaxin-1B	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00034	Integrin signalling pathway	P00924	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00371	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	DANRE|ZFIN=ZDB-GENE-040912-3|UniProtKB=Q66I21	Aldehyde dehydrogenase family 8 member A1	ISS			PTHR43720:SF2	ALDEHYDE DEHYDROGENASE FAMILY 8 MEMBER A1
P02785	Valine biosynthesis	P03218	Dihydroxy isovalerate dehydratase	AQUAE|EnsemblGenome=aq_837|UniProtKB=O67009	Dihydroxy-acid dehydratase	ISS			PTHR43661:SF3	DIHYDROXY-ACID DEHYDRATASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	PANTR|Ensembl=ENSPTRG00000020210|UniProtKB=Q5IS76	Neuronal acetylcholine receptor subunit alpha-6	ISS	15155845	PubMed	PTHR18945:SF82	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-6
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CAEEL|WormBase=WBGene00004055|UniProtKB=Q17446	Mitogen-activated protein kinase pmk-1	IDA	22138445	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	CANLF|Gene=HTR1D|UniProtKB=P11614	5-hydroxytryptamine receptor 1D	ISS	12181435	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	CIOIN|Ensembl=ENSCING00000008616|UniProtKB=F6T2A6	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00021	FGF signaling pathway	P00644	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000009085|UniProtKB=H2RDQ2	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01163	c-Jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	HUMAN|HGNC=4597|UniProtKB=P41594	Metabotropic glutamate receptor 5	ISS	7476890	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P05730	Endogenous cannabinoid signaling	P05746	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00010	B cell activation	P00386	Calcineurin	CANLF|Ensembl=ENSCAFG00000014818|UniProtKB=E2RJ59	Serine/threonine-protein phosphatase	ISS	12091710	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02743	Formyltetrahydroformate biosynthesis	P02956	Formyl tetrahydrofolate deformylase	PSEAE|EnsemblGenome=PA5420|UniProtKB=Q9HTE4	Formyltetrahydrofolate deformylase	ISS			PTHR42706:SF1	FORMYLTETRAHYDROFOLATE DEFORMYLASE 1, MITOCHONDRIAL-RELATED
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	PANTR|Ensembl=ENSPTRG00000018624|UniProtKB=A6H914	TATA box binding protein-like 1	ISS	600075	OMIM	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00557	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02777	Succinate to proprionate conversion	P03163	Methylmalonyl-CoA decarboxylase	DICDI|dictyBase=DDB_G0276341|UniProtKB=Q8T131	Uncharacterized protein	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MOUSE|MGI=MGI=87902|UniProtKB=P68134	Actin, alpha skeletal muscle	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00006	Apoptosis signaling pathway	P00269	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01465	Ggamma	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	ISS	96009592	PubMed	PTHR10048:SF14	PI-3 KINASE
P05913	Enkephalin release	P05974	G-Protein (i)	XENTR|Xenbase=XB-GENE-961282|UniProtKB=Q6DF43	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P05913	Enkephalin release	P05974	G-Protein (i)	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00053	T cell activation	P01300	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	HUMAN|HGNC=130|UniProtKB=P62736	Actin, aortic smooth muscle	IEP	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P04393	Ras Pathway	P04553	PAK	MACMU|Ensembl=ENSMMUG00000001387|UniProtKB=F7D0B4	Uncharacterized protein	ISS	14580336	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	BOVIN|Ensembl=ENSBTAG00000004775|UniProtKB=F1MBY1	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	XENTR|Xenbase=XB-GENE-854877|UniProtKB=F7C949	Presenilin	ISS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00715	AGS3	RAT|RGD=628682|UniProtKB=Q9R080	G-protein-signaling modulator 1	IDA	11121039	PubMed	PTHR10098:SF36	G-PROTEIN-SIGNALING MODULATOR 1
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	DANRE|ZFIN=ZDB-GENE-030616-53|UniProtKB=Q71E60	AMPA receptor subunit GluR3B	ISS	10331083	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00058	mRNA splicing	P01478	U2	MOUSE|MGI=MGI=104805|UniProtKB=Q9CQI7	U2 small nuclear ribonucleoprotein B''	ISS	9716128	PubMed	PTHR10501:SF21	U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B''
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05731	GABA-B receptor II signaling	P05760	AC	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	RCA	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	ANOGA|EnsemblGenome=AGAP002440|UniProtKB=Q17031	Cdc42 homolog	ISS	9658176	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00029	Huntington disease	P00778	NMDA receptor	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BOVIN|Ensembl=ENSBTAG00000005714|UniProtKB=Q3ZC07	Actin, alpha cardiac muscle 1	ISS	3487386	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01428	Frizzled	CANLF|Ensembl=ENSCAFG00000004399|UniProtKB=E2RIL8	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF23	FRIZZLED-4
P00010	B cell activation	P00379	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	PANTR|Ensembl=ENSPTRG00000012128|UniProtKB=H2QI87	Uncharacterized protein	ISS	9118222	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P02770	Pyridoxal phosphate salvage pathway	P03123	Pyridoxine-5-phosphate oxidase	MOUSE|MGI=MGI=2144151|UniProtKB=Q91XF0	Pyridoxine-5'-phosphate oxidase	ISS	9601034	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	IDA	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00020	FAS signaling pathway	P00614	ASK1	MOUSE|MGI=MGI=1346876|UniProtKB=O35099	Mitogen-activated protein kinase kinase kinase 5	TAS			PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00056	VEGF signaling pathway	P01417	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00059	p53 pathway	P01485	p53	MOUSE|MGI=MGI=1330810|UniProtKB=O88898	Tumor protein 63	TAS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00047	PDGF signaling pathway	P01168	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	CAEEL|WormBase=WBGene00004860|UniProtKB=Q09488	Serine/threonine-protein kinase sma-6	TAS	10683140	PubMed	PTHR23255:SF68	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00005	Angiogenesis	P00235	c-Fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00045	Notch signaling pathway	P01104	Serrate	PANTR|Ensembl=ENSPTRG00000013250|UniProtKB=H2QJZ0	Delta-like protein	ISS	8955070	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2848|UniProtKB=P08909	5-hydroxytryptamine receptor 2C	IDA			PTHR24247:SF32	5-HYDROXYTRYPTAMINE RECEPTOR 2C
P00047	PDGF signaling pathway	P01173	STAT	MACMU|Ensembl=ENSMMUG00000010707|UniProtKB=F7G8G5	Signal transducer and activator of transcription	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00056	VEGF signaling pathway	P01407	Erk	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	AQUAE|EnsemblGenome=aq_1172|UniProtKB=O67233	Carbamoyl-phosphate synthase large chain, C-terminal section	ISS			PTHR11405:SF5	CAD PROTEIN
P00059	p53 pathway	P04629	PCAF	MOUSE|MGI=MGI=1343094|UniProtKB=Q9JHD1	Histone acetyltransferase KAT2B	ISS	12724314	PubMed	PTHR22880:SF116	HISTONE ACETYLTRANSFERASE KAT2B
P00048	PI3 kinase pathway	P01179	PKB	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00238	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	IDA	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	DROME|FlyBase=FBgn0003888|UniProtKB=P08841	Tubulin beta-3 chain	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00018	EGF receptor signaling pathway	P00560	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT3G59790|UniProtKB=Q9M1Z5	Mitogen-activated protein kinase 10	ISS	11707292	PubMed	PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P00006	Apoptosis signaling pathway	P00318	PKCs	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	IDA	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00047	PDGF signaling pathway	P01155	Jak	DANRE|ZFIN=ZDB-GENE-980526-481|UniProtKB=F1QWX8	Tyrosine-protein kinase	ISS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00012	Cadherin signaling pathway	P00464	Fyn	DANRE|ZFIN=ZDB-GENE-050706-89|UniProtKB=F1RDG9	Tyrosine-protein kinase fynb	ISS	11162638	PubMed	PTHR24418:SF242	TYROSINE-PROTEIN KINASE FYNB
P00034	Integrin signalling pathway	P00927	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00029	Huntington disease	P00778	NMDA receptor	BOVIN|Ensembl=ENSBTAG00000047202|UniProtKB=G3N3K3	Uncharacterized protein	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05915	Opioid proenkephalin pathway	P05988	peptide E	PANTR|Ensembl=ENSPTRG00000020270|UniProtKB=H2QW70	Proenkephalin	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01326	CD3 delta	PANTR|Ensembl=ENSPTRG00000004339|UniProtKB=H2Q4W0	Uncharacterized protein	ISS	9348303	PubMed	PTHR10570:SF5	T-CELL SURFACE GLYCOPROTEIN CD3 DELTA CHAIN
P00005	Angiogenesis	P00219	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	DANRE|ZFIN=ZDB-GENE-030131-7595|UniProtKB=Q6PBR4	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00019	Endothelin signaling pathway	P00586	Gq	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	XENTR|Xenbase=XB-GENE-960148|UniProtKB=F6XMD3	Protein Wnt (Fragment)	ISS	8717036	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00756	Recoverin	HUMAN|HGNC=9937|UniProtKB=P35243	Recoverin	IDA	7953452	PubMed	PTHR23055:SF20	RECOVERIN
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	TAS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CAEBR|Gene=CBG05858|UniProtKB=A8X1H0	Protein CBR-EGL-19 (Fragment)	ISS	9199552	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00047	PDGF signaling pathway	P01143	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000014828|UniProtKB=F1N1E0	Uncharacterized protein	ISS	8386525	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00048	PI3 kinase pathway	G01545	scl-1	CAEEL|WormBase=WBGene00009891|UniProtKB=Q20609	SCP-Like extracellular protein	ISS			PTHR10334:SF256	SCP-LIKE EXTRACELLULAR PROTEIN
P00005	Angiogenesis	P00219	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	CAEEL|WormBase=WBGene00000900|UniProtKB=P50488	Cell surface receptor daf-4	TAS	10887089	PubMed	PTHR23255:SF70	SERINE/THREONINE-PROTEIN KINASE RECEPTOR
P05917	Opioid proopiomelanocortin pathway	P06011	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=3346|UniProtKB=P10688	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	10934033	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00010	B cell activation	P00398	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	ARATH|TAIR=AT4G00720|UniProtKB=Q96287	Shaggy-related protein kinase theta	IDA			PTHR24057:SF19	SHAGGY-RELATED PROTEIN KINASE BETA-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	CANLF|Gene=PSEN1|UniProtKB=Q6RH31	Presenilin-1	ISS	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	RAT|RGD=621705|UniProtKB=Q8VHN2	Glutamate receptor ionotropic, NMDA 3B	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P00047	PDGF signaling pathway	P01148	Grb2	XENTR|Xenbase=XB-GENE-6070000|UniProtKB=Q66II3	Growth factor receptor-bound protein 2	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00030	Hypoxia response via HIF activation	P00814	P300	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	RCA	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00010	B cell activation	P00383	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04392	P53 pathway feedback loops 1	P04537	p73DeltaN	HUMAN|HGNC=15979|UniProtKB=Q9H3D4	Tumor protein 63	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01443	Phospholipase C	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IDA	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05918	p38 MAPK pathway	P06031	p38alpha	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	RCA	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	ISS	188830	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	RAT|RGD=1359694|UniProtKB=P62836	Ras-related protein Rap-1A	ISS	1904317	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000011256|UniProtKB=F6R1W9	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF46	ALPHA-CENTRACTIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	TAS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00021	FGF signaling pathway	P00629	PP2A	ORNAN|Ensembl=ENSOANG00000008492|UniProtKB=F6XL57	Uncharacterized protein	ISS	12110603	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	RAT|RGD=619966|UniProtKB=F1LQT1	Adenylate cyclase 7	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00006	Apoptosis signaling pathway	P00274	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000024992|UniProtKB=F6TUR3	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04398	p53 pathway feedback loops 2	P04669	ATM	RAT|RGD=1593265|UniProtKB=D4ACL8	Ataxia telangiectasia mutated homolog (Human) (Mapped), isoform CRA_a	ISS			PTHR11139:SF72	SERINE-PROTEIN KINASE ATM
P00005	Angiogenesis	P00237	FRP	PANTR|Ensembl=ENSPTRG00000020192|UniProtKB=H2R9U6	Secreted frizzled-related protein 1	ISS	9096311	PubMed	PTHR11309:SF87	SECRETED FRIZZLED-RELATED PROTEIN 1
P00008	Axon guidance mediated by Slit/Robo	P00355	Rho	SCHPO|PomBase=SPAC16A10.04|UniProtKB=Q874R1	GTP-binding protein rho4	ISS			PTHR24072:SF181	SUBFAMILY NOT NAMED
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	SCHPO|PomBase=SPCC1259.06|UniProtKB=O94706	Transcription initiation factor TFIID subunit 8	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00010	B cell activation	P00369	MEKK	MACMU|Ensembl=ENSMMUG00000018568|UniProtKB=F6YLW2	Uncharacterized protein	ISS	8649450	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	TAS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	94280860	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00029	Huntington disease	P00807	Actin	CHICK|Ensembl=ENSGALG00000014620|UniProtKB=F1N8P3	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00005	Angiogenesis	P00243	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00941	Integrin alpha	RAT|RGD=1593249|UniProtKB=D3ZMQ3	Protein Itga4	ISS	3487386	PubMed	PTHR23220:SF78	INTEGRIN ALPHA-4
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9405|UniProtKB=Q16512	Serine/threonine-protein kinase N1	TAS	10644715	PubMed	PTHR24356:SF246	SERINE/THREONINE-PROTEIN KINASE N1
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04398	p53 pathway feedback loops 2	P04665	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	91056091	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00057	Wnt signaling pathway	P01453	Ebi	MACMU|Ensembl=ENSMMUG00000006191|UniProtKB=F7HNU9	F-box-like/WD repeat-containing protein TBL1X isoform a	ISS	11389839	PubMed	PTHR22846:SF2	F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN TBL1X
P00021	FGF signaling pathway	P00627	ERK1-2	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00052	TGF-beta signaling pathway	P01284	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00006	Apoptosis signaling pathway	P00302	ATF	PANTR|Ensembl=ENSPTRG00000005022|UniProtKB=H2Q627	Activating transcription factor 7	ISS	11390664	PubMed	PTHR19304:SF10	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-7
P00057	Wnt signaling pathway	P01440	Cadherin	CHICK|Gene=CDH20|UniProtKB=Q8QGH3	Cadherin-20	IDA	8120095	PubMed	PTHR24027:SF84	CADHERIN-20
P00019	Endothelin signaling pathway	P00572	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00012	Cadherin signaling pathway	P00475	Frizzled	XENTR|Xenbase=XB-GENE-479707|UniProtKB=F6QAW3	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF126	FRIZZLED-5
P00036	Interleukin signaling pathway	P00966	mTOR	MOUSE|MGI=MGI=1928394|UniProtKB=Q9JLN9	Serine/threonine-protein kinase mTOR	ISS	8662507	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	EMENI|EnsemblGenome=CADANIAG00002024|UniProtKB=Q00743	Guanine nucleotide-binding protein subunit alpha	ISS			PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00107	kinesin	PANTR|Ensembl=ENSPTRG00000003914|UniProtKB=H2Q459	Kinesin light chain 2	ISS	11740561	PubMed	PTHR19959:SF177	KINESIN LIGHT CHAIN 2
P00029	Huntington disease	P00811	Arp2/3 complex	SCHPO|PomBase=SPBC14C8.06|UniProtKB=P78774	Actin-related protein 2/3 complex subunit 1	TAS	12932731	PubMed	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_127489|UniProtKB=C3XYC6	Putative uncharacterized protein	IDA	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00018	EGF receptor signaling pathway	P00547	PP2A	MACMU|Ensembl=ENSMMUG00000013047|UniProtKB=F7H808	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00807	Actin	PHYPA|Gene=PHYPADRAFT_198730|UniProtKB=Q6TYS2	Actin 1	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00005	Angiogenesis	P00223	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02769	Purine metabolism	P03118	Guanine Deaminase	HUMAN|HGNC=4212|UniProtKB=Q9Y2T3	Guanine deaminase	NAS	11837778	gi	PTHR11271:SF6	GUANINE DEAMINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00238	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00021	FGF signaling pathway	P00646	RasGAP	ORNAN|Ensembl=ENSOANG00000014753|UniProtKB=F7EPN2	Uncharacterized protein (Fragment)	ISS	15489039	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00005	Angiogenesis	P00254	GTPase	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g243859|UniProtKB=A7S9Y5	Predicted protein	ISS			PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	DAPPU|EnsemblGenome=DAPPUDRAFT_301140|UniProtKB=E9HGM4	Putative uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P02738	De novo purine biosynthesis	P02901	Adenosuccinate lyase	DROME|FlyBase=FBgn0038467|UniProtKB=Q9VEP6	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P00035	Interferon-gamma signaling pathway	P00956	SOCS	MACMU|Ensembl=ENSMMUG00000017522|UniProtKB=F6UUY8	Uncharacterized protein	ISS	15032587	PubMed	PTHR44534:SF3	SUPPRESSOR OF CYTOKINE SIGNALING 3
P06959	CCKR signaling map	G07289	NR4A1	HUMAN|HGNC=7980|UniProtKB=P22736	Nuclear receptor subfamily 4 group A member 1	RCA	17962809	PubMed	PTHR24085:SF1	NUCLEAR RECEPTOR SUBFAMILY 4 GROUP A MEMBER 1
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	HUMAN|HGNC=1388|UniProtKB=O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	14507926	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00012	Cadherin signaling pathway	P00470	F-actin	TRIVA|Gene=TVAG_090470|UniProtKB=A2FA04	Actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05731	GABA-B receptor II signaling	P05760	AC	BOVIN|Gene=ADCY1|UniProtKB=P19754	Adenylate cyclase type 1	RCA	89298382	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DANRE|ZFIN=ZDB-GENE-040426-1354|UniProtKB=Q7T2C5	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04393	Ras Pathway	P04570	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IDA	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02738	De novo purine biosynthesis	P02899	GMP synthase	DICDI|dictyBase=DDB_G0281551|UniProtKB=P32073	GMP synthase [glutamine-hydrolyzing]	ISS			PTHR11922:SF2	GMP SYNTHASE  GLUTAMINE-HYDROLYZING
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00049	Parkinson disease	P01238	14-3-3	PANTR|Ensembl=ENSPTRG00000008521|UniProtKB=G2HI54	14-3-3 protein epsilon	ISS	9450960	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P02738	De novo purine biosynthesis	P02906	N5-carboxyaminoimidazole ribonucleotide synthase	METAC|EnsemblGenome=MA_1376|UniProtKB=Q8TR08	Phosphoribosylaminoimidazole carboxylase	ISS			PTHR23046:SF2	N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE MUTASE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=2136747|UniProtKB=Q91Y07	MCG141300	IDA	8120095	PubMed	PTHR24028:SF95	MCG141300
P06215	MYO signaling pathway	P06311	MED	DROME|FlyBase=FBgn0011655|UniProtKB=O62609	Mothers against decapentaplegic homolog	IEA	http://flybase.org/reports/FBgn0011655.html	Website	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P00059	p53 pathway	G01575	GADD45	CANLF|Ensembl=ENSCAFG00000019386|UniProtKB=E2R2S2	Uncharacterized protein	ISS	10097101	PubMed	PTHR10411:SF5	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 BETA
P00018	EGF receptor signaling pathway	P00551	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	G04696	Siah	MOUSE|MGI=MGI=108063|UniProtKB=Q06985	E3 ubiquitin-protein ligase SIAH1B	IDA	15326481	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01177	P110ACT	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	IC	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	CHICK|Ensembl=ENSGALG00000002932|UniProtKB=O57535	Nucleoside diphosphate kinase	ISS			PTHR11349:SF57	NUCLEOSIDE DIPHOSPHATE KINASE B
P00007	Axon guidance mediated by semaphorins	P00340	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	15470041	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00034	Integrin signalling pathway	P00942	Fyn	CANLF|Ensembl=ENSCAFG00000003995|UniProtKB=E2RC09	Tyrosine-protein kinase	ISS	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00034	Integrin signalling pathway	P00949	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	95096035	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P02787	Vitamin B6 metabolism	P03242	Threonine synthase	SCHPO|PomBase=SPAC9E9.06c|UniProtKB=Q42598	Threonine synthase	ISS	11859360	PubMed	PTHR42690:SF1	THREONINE SYNTHASE-LIKE 2
P04393	Ras Pathway	P04556	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IDA	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05730	Endogenous cannabinoid signaling	P05746	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	MOUSE|MGI=MGI=2443731|UniProtKB=Q3THS6	S-adenosylmethionine synthase isoform type-2	ISS			PTHR11964:SF12	S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2
P02744	Fructose galactose metabolism	P02964	Hexose 1-P uridyltransferase	PANTR|Ensembl=ENSPTRG00000020886|UniProtKB=H2QX69	Galactose-1-phosphate uridylyltransferase	ISS	1610789	PubMed	PTHR11943:SF1	GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE
P00057	Wnt signaling pathway	P01471	alpha-catenin	PANTR|Ensembl=ENSPTRG00000017291|UniProtKB=H2QRK9	Catenin (Cadherin-associated protein), alpha 1, 102kDa	ISS	1768802	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00048	PI3 kinase pathway	G01546	Cyclin d	BOVIN|Ensembl=ENSBTAG00000017514|UniProtKB=Q2KI22	G1/S-specific cyclin-D1	ISS	12356903	PubMed	PTHR10177:SF67	G1/S-SPECIFIC CYCLIN-D1
P00049	Parkinson disease	P01242	Casein kinase I	HUMAN|HGNC=2452|UniProtKB=P48730	Casein kinase I isoform delta	IDA	11437445	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01080	AChE	BRAFL|Gene=BRAFLDRAFT_116869|UniProtKB=C3ZD75	Carboxylic ester hydrolase	ISS	86008285	PubMed	PTHR11559:SF356	ACETYLCHOLINESTERASE
P00046	Oxidative stress response	P01131	MKP5	MOUSE|MGI=MGI=106626|UniProtKB=O09112	Dual specificity protein phosphatase 8	TAS			PTHR10159:SF108	DUAL SPECIFICITY PROTEIN PHOSPHATASE 8
P00057	Wnt signaling pathway	P01472	Histone deacetylase	EMENI|EnsemblGenome=CADANIAG00005952|UniProtKB=G5EB64	Uncharacterized protein	IDA	10485845	PubMed	PTHR10625:SF141	HISTONE DEACETYLASE RPD3
P00021	FGF signaling pathway	P00634	MEKK1-5	MACMU|Ensembl=ENSMMUG00000016376|UniProtKB=F7G2W1	Uncharacterized protein	ISS	12697749	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00011	Blood coagulation	P00409	PAI-2	PANTR|Ensembl=ENSPTRG00000023897|UniProtKB=H2QEN1	Uncharacterized protein	ISS	4505595	gi	PTHR11461:SF61	PLASMINOGEN ACTIVATOR INHIBITOR 2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00021	FGF signaling pathway	P00642	MEK1-2	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IGI	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00012	Cadherin signaling pathway	P00470	F-actin	CAEEL|WormBase=WBGene00000063|UniProtKB=P0DM41	Actin-1	IC	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00012	Cadherin signaling pathway	P00463	betacatenin	TAKRU|Ensembl=ENSTRUG00000003520|UniProtKB=H2S791	Uncharacterized protein	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	XENTR|Xenbase=XB-GENE-5801166|UniProtKB=F6ZE26	Uncharacterized protein	ISS	10476970	PubMed	PTHR24070:SF382	RAS-RELATED PROTEIN RAP-1B
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00049	Parkinson disease	P01211	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	BOVIN|Gene=PPP1CB|UniProtKB=Q3SWW9	Serine/threonine-protein phosphatase PP1-beta catalytic subunit	ISS	8392016	PubMed	PTHR11668:SF282	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-BETA CATALYTIC SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	TAS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P01485	p53	RAT|RGD=1307083|UniProtKB=D4AA88	Protein Tp73	ISS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P02748	Isoleucine biosynthesis	P02997	Acetolactate synthase	SCHPO|PomBase=SPBP35G2.07|UniProtKB=P36620	Acetolactate synthase, mitochondrial	ISS			PTHR18968:SF13	ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	BOVIN|Ensembl=ENSBTAG00000037429|UniProtKB=F1MGM3	Uncharacterized protein	ISS			PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05918	p38 MAPK pathway	P06015	p38gamma	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00010	B cell activation	P00398	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00021	FGF signaling pathway	P00629	PP2A	BRAFL|Gene=BRAFLDRAFT_113834|UniProtKB=C3ZG26	Serine/threonine-protein phosphatase	ISS			PTHR11668:SF24	SERINE/THREONINE-PROTEIN PHOSPHATASE 6 CATALYTIC SUBUNIT
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00474	Wnt	CAEBR|Gene=CBG03476|UniProtKB=A8WV58	Protein CBR-EGL-20	ISS	11266476	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00709	Glycogen synthase D	MACMU|Gene=GYS1|UniProtKB=Q8MJ26	Glycogen [starch] synthase, muscle	ISS	4212312	PubMed	PTHR10176:SF2	GLYCOGEN  STARCH  SYNTHASE, MUSCLE
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	HALSA|EnsemblGenome=AAC82822|UniProtKB=Q48325	TATA-box-binding protein B	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IDA	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00021	FGF signaling pathway	P00624	14-3-3	CANLF|Ensembl=ENSCAFG00000009514|UniProtKB=F1PKW7	Uncharacterized protein	ISS	9055384	gi	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	RCA	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00225	MEK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS			PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04375	5HT3 type receptor mediated signaling pathway	P04425	K+ channel	MONDO|Ensembl=ENSMODG00000015769|UniProtKB=F6ZSC2	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P04393	Ras Pathway	P04559	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	PANTR|Ensembl=ENSPTRG00000018312|UniProtKB=H2QT92	Uncharacterized protein	ISS			PTHR43407:SF1	LENGSIN
P00057	Wnt signaling pathway	P01447	Dishevelled	RAT|RGD=1309725|UniProtKB=D3ZB71	Protein Dvl2	ISS	10409711	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00973	PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00965	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01451	Galpha	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IDA	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MONDO|Ensembl=ENSMODG00000015246|UniProtKB=F6UJF5	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00005	Angiogenesis	P00219	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00047	PDGF signaling pathway	P01147	Nck	PANTR|Ensembl=ENSPTRG00000015434|UniProtKB=G2HHN0	Cytoplasmic protein NCK1	ISS	12874226	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P00053	T cell activation	P01334	WASP	MACMU|Ensembl=ENSMMUG00000019767|UniProtKB=F7AQ11	Uncharacterized protein	ISS	10544204	PubMed	PTHR23202:SF35	WISKOTT-ALDRICH SYNDROME PROTEIN
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	TAS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000003043|UniProtKB=P63212	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	DICPU|Gene=DICPUDRAFT_92985|UniProtKB=F1A084	Putative uncharacterized protein rac1A	ISS			PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00029	Huntington disease	P00812	Caspase 3	DANRE|ZFIN=ZDB-GENE-011210-1|UniProtKB=B8JK21	Uncharacterized protein	IDA	11675509	PubMed	PTHR10454:SF198	CASPASE-3
P00029	Huntington disease	P00810	GAPDH	RAT|RGD=1560797|UniProtKB=D3ZGY4	Glyceraldehyde-3-phosphate dehydrogenase	ISS	8612237	PubMed	PTHR10836:SF51	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IDA	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00004	Alzheimer disease-presenilin pathway	P00114	actin	TAKRU|Ensembl=ENSTRUG00000004787|UniProtKB=P53480	Actin, alpha cardiac	IDA	11889126	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00006	Apoptosis signaling pathway	P00302	ATF	MOUSE|MGI=MGI=2443472|UniProtKB=Q8R0S1	Cyclic AMP-dependent transcription factor ATF-7	ISS	11390664	PubMed	PTHR19304:SF10	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-7
P00018	EGF receptor signaling pathway	P00561	STAT	BOVIN|Gene=STAT5A|UniProtKB=Q95115	Signal transducer and activator of transcription 5A	ISS	95188889	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MOUSE|MGI=MGI=109246|UniProtKB=P97288	5-hydroxytryptamine receptor 4	IDA	12898568	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P00005	Angiogenesis	P00194	Paxillin	PANTR|Ensembl=ENSPTRG00000008048|UniProtKB=H2R4E5	Transforming growth factor beta 1 induced transcript 1	ISS			PTHR24216:SF27	TRANSFORMING GROWTH FACTOR BETA-1-INDUCED TRANSCRIPT 1 PROTEIN
P00049	Parkinson disease	P01211	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05918	p38 MAPK pathway	P06026	MEKK4	RAT|RGD=1311192|UniProtKB=A0A0G2K3R1	Protein Map3k4	ISS	10207617	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	91056091	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00010	B cell activation	P00402	Jnk	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00045	Notch signaling pathway	P01104	Serrate	CANLF|Ensembl=ENSCAFG00000005627|UniProtKB=E2QUR0	Delta-like protein	ISS	7697721	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P05731	GABA-B receptor II signaling	P05754	Ggamma	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00013	Cell cycle	P00480	Proteasome	SCHMA|EnsemblGenome=Smp_000740|UniProtKB=Q547D2	Multiubiquitin binding protein S5a	NAS	3914476	gi	PTHR10223:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CHICK|Gene=MYO6|UniProtKB=Q9I8D1	Unconventional myosin-VI	IC			PTHR13140:SF706	UNCONVENTIONAL MYOSIN-VI
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00559	MEK1-2	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00006	Apoptosis signaling pathway	P00317	Fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00053	T cell activation	P01311	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	RCA	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00058	mRNA splicing	P01476	U4	MOUSE|MGI=MGI=1918017|UniProtKB=Q922U1	U4/U6 small nuclear ribonucleoprotein Prp3	ISS	12875835	PubMed	PTHR14212:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3
P04393	Ras Pathway	P04547	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P04393	Ras Pathway	P04578	Rho	CAEBR|Gene=CBG13664|UniProtKB=A8XIF5	Protein CBR-RHO-1	ISS	11973360	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00036	Interleukin signaling pathway	P00981	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	TAS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05913	Enkephalin release	P05977	G-Protein (s)	HUMAN|HGNC=4404|UniProtKB=P59768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IDA	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CANLF|Ensembl=ENSCAFG00000001738|UniProtKB=E2RDG9	Uncharacterized protein	ISS			PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P02783	Tryptophan biosynthesis	P03210	Indole-3-glycerol phosphate synthase	STRCO|EnsemblGenome=CAB38582|UniProtKB=Q9Z4X0	Indole-3-glycerol phosphate synthase 2	ISS			PTHR22854:SF2	TRYPTOPHAN BIOSYNTHESIS PROTEIN TRPCF
P00047	PDGF signaling pathway	P01174	Rho	HUMAN|HGNC=17073|UniProtKB=Q9UNA1	Rho GTPase-activating protein 26	ISS	8649427	PubMed	PTHR12552:SF4	RHO GTPASE-ACTIVATING PROTEIN 26
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04393	Ras Pathway	P04558	p38	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	IC	10477300	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04661	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00018	EGF receptor signaling pathway	P00539	14-3-3	RAT|RGD=1359510|UniProtKB=Q5EBB0	Protein LOC298795	ISS	10407019	PubMed	PTHR18860:SF14	14-3-3 PROTEIN SIGMA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	MACMU|Ensembl=ENSMMUG00000018136|UniProtKB=F7DHW8	G protein-activated inward rectifier potassium channel 2	ISS	2433589	PubMed	PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P00005	Angiogenesis	P00243	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04395	Vasopressin synthesis	P04593	Glycopeptide	MACMU|Ensembl=ENSMMUG00000010678|UniProtKB=F7AXI7	Uncharacterized protein	ISS	6717565	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00010	B cell activation	P00369	MEKK	PANTR|Ensembl=ENSPTRG00000012427|UniProtKB=H2QIN7	Mitogen-activated protein kinase kinase kinase 2	ISS	8621389	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P06959	CCKR signaling map	P07099	PKA-Calpha/beta/gamma	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	RCA	7935349	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P05731	GABA-B receptor II signaling	P05754	Ggamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	RCA	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00020	FAS signaling pathway	P00615	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00034	Integrin signalling pathway	P00925	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	IDA	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000007445|UniProtKB=F6SWI4	Uncharacterized protein	ISS	20088160	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	TAS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	ARATH|TAIR=AT3G11820|UniProtKB=Q9ZSD4	Syntaxin-121	IC			PTHR19957:SF69	SYNTAXIN-121-RELATED
P00029	Huntington disease	P00775	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00048	PI3 kinase pathway	P01187	IR	BOVIN|Ensembl=ENSBTAG00000012687|UniProtKB=F1MV64	Tyrosine-protein kinase receptor	ISS	249616	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00012	Cadherin signaling pathway	P00475	Frizzled	CHICK|Gene=FZD1|UniProtKB=O57328	Frizzled-1	IDA	8717036	PubMed	PTHR11309:SF81	FRIZZLED-1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	CHICK|Ensembl=ENSGALG00000017178|UniProtKB=F1N982	Uncharacterized protein	ISS	12497607	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	TAS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00046	Oxidative stress response	P01131	MKP5	HUMAN|HGNC=19681|UniProtKB=Q9UII6	Dual specificity protein phosphatase 13 isoform B	ISS			PTHR10159:SF365	DUAL SPECIFICITY PROTEIN PHOSPHATASE 13 ISOFORM B
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	IC	11319238	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PANTR|Ensembl=ENSPTRG00000018890|UniProtKB=Q5R1X3	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DROME|FlyBase=FBgn0000489|UniProtKB=P16912	Protein kinase DC2	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000002349|UniProtKB=P61267	Syntaxin-1B	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Ensembl=ENSGALG00000015358|UniProtKB=F1NM49	Uncharacterized protein	IEP	10938134	PubMed	PTHR13140:SF575	MYOSIN-15
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	LEIMA|Gene=LmjF06.0860|UniProtKB=P07382	Bifunctional dihydrofolate reductase-thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DANRE|ZFIN=ZDB-GENE-041001-104|UniProtKB=Q5TZD4	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00220	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	MONDO|Ensembl=ENSMODG00000012785|UniProtKB=F6S0M5	Uncharacterized protein	ISS	604904	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01160	IP3 receptor	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	IDA	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00048	PI3 kinase pathway	P01192	p110	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04548	ATF2	PANTR|Ensembl=ENSPTRG00000012660|UniProtKB=H2QJ07	Activating transcription factor 2	ISS	9819389	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MOUSE|MGI=MGI=87938|UniProtKB=P18762	Beta-2 adrenergic receptor	IDA	12063255	PubMed	PTHR24248:SF21	BETA-2 ADRENERGIC RECEPTOR
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DICPU|Gene=DICPUDRAFT_93216|UniProtKB=F1A421	Guanine nucleotide-binding protein subunit beta	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04393	Ras Pathway	P04558	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	MOUSE|MGI=MGI=105083|UniProtKB=P51906	Excitatory amino acid transporter 3	ISS	94365697	PubMed	PTHR11958:SF69	EXCITATORY AMINO ACID TRANSPORTER 3
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05730	Endogenous cannabinoid signaling	P05746	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	PANTR|Ensembl=ENSPTRG00000008343|UniProtKB=H2QBI1	Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 7	ISS	95275316	PubMed	PTHR10540:SF7	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00739	AGS3	RAT|RGD=628682|UniProtKB=Q9R080	G-protein-signaling modulator 1	IDA	11121039	PubMed	PTHR10098:SF36	G-PROTEIN-SIGNALING MODULATOR 1
P00053	T cell activation	P01300	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00014	Cholesterol biosynthesis	P00494	Squalene monooxygenas	YEAST|SGD=S000003407|UniProtKB=P32476	Squalene monooxygenase	ISS			PTHR10835:SF0	SQUALENE MONOOXYGENASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MACMU|Ensembl=ENSMMUG00000001458|UniProtKB=F7BKH1	Uncharacterized protein	ISS	12932731	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00056	VEGF signaling pathway	P01408	Akt/PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01188	Gbetagamma	MOUSE|MGI=MGI=101848|UniProtKB=P62881	Guanine nucleotide-binding protein subunit beta-5	IC	10051575	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P06209	ALP23B signaling pathway	P06221	MED	DROME|FlyBase=FBgn0011648|UniProtKB=P42003	Protein mothers against dpp	RCA			PTHR13703:SF40	PROTEIN MOTHERS AGAINST DPP
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	129387	gi	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	IC	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00056	VEGF signaling pathway	P01418	Paxillin	PANTR|Ensembl=ENSPTRG00000003681|UniProtKB=H2Q3Q1	Leupaxin	ISS			PTHR24216:SF23	LEUPAXIN
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	BOVIN|Ensembl=ENSBTAG00000011579|UniProtKB=F1N5C5	Muscarinic acetylcholine receptor	ISS	12181435	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	RAT|RGD=71014|UniProtKB=Q04400	Adenylate cyclase type 5	IGI	1409703	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05916	Opioid prodynorphin pathway	P05999	provasopressin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	XENTR|Xenbase=XB-GENE-480347|UniProtKB=Q6P640	Actin, alpha cardiac muscle 1	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00010	B cell activation	P00383	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IDA	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=103077|UniProtKB=Q64704	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00641	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	IC	11889126	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00766	Htt	MACMU|Ensembl=ENSMMUG00000008392|UniProtKB=F6VQZ3	Uncharacterized protein	ISS	8268927	PubMed	PTHR10170:SF10	HUNTINGTIN
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CANLF|Ensembl=ENSCAFG00000013148|UniProtKB=Q5R1P3	Glutamate receptor ionotropic, NMDA 2B	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00047	PDGF signaling pathway	P01143	ERK	RAT|RGD=621505|UniProtKB=P0C865	Mitogen-activated protein kinase 7	ISS	12912994	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P05913	Enkephalin release	P05972	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01174	Rho	PANTR|Ensembl=ENSPTRG00000002406|UniProtKB=H2Q1S9	Uncharacterized protein	ISS			PTHR23181:SF3	RHO GTPASE-ACTIVATING PROTEIN 12
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00049	Parkinson disease	P01211	ERK	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	IDA	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00866	Cytokine receptor	PANTR|Ensembl=ENSPTRG00000013867|UniProtKB=H2QKY9	Interferon (Alpha, beta and omega) receptor 1	ISS	12163451	PubMed	PTHR20859:SF54	INTERFERON ALPHA/BETA RECEPTOR 1
P00047	PDGF signaling pathway	P01143	ERK	RAT|RGD=621505|UniProtKB=P0C865	Mitogen-activated protein kinase 7	ISS	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00053	T cell activation	P01300	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00012	Cadherin signaling pathway	P00475	Frizzled	CANLF|Ensembl=ENSCAFG00000008293|UniProtKB=E2R9M9	Uncharacterized protein	ISS	12549854	PubMed	PTHR11309:SF22	FRIZZLED-3
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	XENTR|Xenbase=XB-GENE-493937|UniProtKB=Q5M8T9	Actin, alpha 2, smooth muscle, aorta	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	DANRE|ZFIN=ZDB-GENE-051202-1|UniProtKB=E7F101	Uncharacterized protein	ISS	14698601	PubMed	PTHR44391:SF2	SUBFAMILY NOT NAMED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	RAT|RGD=620200|UniProtKB=P80201	Activin receptor type-1	TAS	9395284	PubMed	PTHR23255:SF69	ACTIVIN RECEPTOR TYPE-1
P04393	Ras Pathway	P04547	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P02734	Chorismate biosynthesis	P02871	2-Deoxy-7-phosphoheptulonate synthase	SCHPO|PomBase=SPAP8A3.07c|UniProtKB=Q9UT09	Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited	ISS			PTHR21225:SF0	PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, TYROSINE-INHIBITED
P00021	FGF signaling pathway	P00644	p38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IGI	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00019	Endothelin signaling pathway	P00586	Gq	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00059	p53 pathway	P04609	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00034	Integrin signalling pathway	P00948	Rho	PANTR|Ensembl=ENSPTRG00000014922|UniProtKB=H2QML4	Uncharacterized protein	ISS	12039949	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00049	Parkinson disease	P01238	14-3-3	MOUSE|MGI=MGI=109484|UniProtKB=P63101	14-3-3 protein zeta/delta	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00052	TGF-beta signaling pathway	P01281	SARA	ANOGA|EnsemblGenome=AGAP004049|UniProtKB=Q7QH71	AGAP004049-PA	TAS	12040180	PubMed	PTHR22835:SF299	FI05490P
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	7492337	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	HUMAN|HGNC=132|UniProtKB=P60709	Actin, cytoplasmic 1	IC	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DICDI|dictyBase=DDB_G0269234|UniProtKB=P07830	Major actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	HUMAN|HGNC=7851|UniProtKB=Q13232	Nucleoside diphosphate kinase 3	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P00056	VEGF signaling pathway	P01417	Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	ISS	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05730	Endogenous cannabinoid signaling	P05746	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IC	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	PANTR|Ensembl=ENSPTRG00000003199|UniProtKB=H2Q2X8	Uncharacterized protein	ISS			PTHR18945:SF768	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-10
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00018	EGF receptor signaling pathway	P00546	GAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	IGI	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05913	Enkephalin release	P05973	GPCR (i)	MACMU|Ensembl=ENSMMUG00000009389|UniProtKB=F7HEV7	Uncharacterized protein	ISS	11259498	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00029	Huntington disease	P00780	Microtubule	CAEEL|WormBase=WBGene00006536|UniProtKB=O17921	TuBulin, Beta	IDA	12932731	PubMed	PTHR11588:SF157	TUBULIN, BETA
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	HUMAN|HGNC=4593|UniProtKB=Q13255	Metabotropic glutamate receptor 1	ISS	9407094	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P06587	Nicotine pharmacodynamics pathway	P06608	DDC	HUMAN|HGNC=2719|UniProtKB=P20711	Aromatic-L-amino-acid decarboxylase	TAS	107930	OMIM	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00046	Oxidative stress response	P01131	MKP5	ARATH|TAIR=AT3G55270|UniProtKB=Q9C5S1	Protein-tyrosine-phosphatase MKP1	ISS			PTHR10159:SF326	LAFORIN
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00054	Toll receptor signaling pathway	P01356	ERK2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P06664	Gonadotropin-releasing hormone receptor pathway	P06834	MAP3Ks	MOUSE|MGI=MGI=1346876|UniProtKB=O35099	Mitogen-activated protein kinase kinase kinase 5	RCA	12566458	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00010	B cell activation	P00375	Calmodulin	DANRE|Ensembl=ENSDARG00000015050|UniProtKB=Q6PI52	Calmodulin	ISS	10487978	PubMed	PTHR23050:SF326	CALMODULIN
P00012	Cadherin signaling pathway	P00473	P120	MACMU|Ensembl=ENSMMUG00000023419|UniProtKB=F7F975	Uncharacterized protein	ISS			PTHR10372:SF9	CATENIN DELTA-2
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00875	GEF	RAT|RGD=1306534|UniProtKB=D3ZS72	Protein Prex1	ISS	11955434	PubMed	PTHR22829:SF6	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE-DEPENDENT RAC EXCHANGER 1 PROTEIN
P00034	Integrin signalling pathway	P00951	Jnk	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IDA	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04397	p53 pathway by glucose deprivation	P04646	alpha4	MACMU|Ensembl=ENSMMUG00000013929|UniProtKB=F6SMB6	Uncharacterized protein	ISS	9647778	PubMed	PTHR10933:SF9	IMMUNOGLOBULIN-BINDING PROTEIN 1
P00010	B cell activation	P00379	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00008	Axon guidance mediated by Slit/Robo	P00355	Rho	MONDO|Ensembl=ENSMODG00000000981|UniProtKB=F7ES59	Uncharacterized protein	ISS	12090470	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	CHICK|Ensembl=ENSGALG00000005065|UniProtKB=P49147	Cytosolic phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00018	EGF receptor signaling pathway	P00558	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04393	Ras Pathway	P04557	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	IDA	94313981	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=109356|UniProtKB=O09044	Synaptosomal-associated protein 23	IC	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00048	PI3 kinase pathway	P01199	Galpha	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P06959	CCKR signaling map	P07098	p46 SHC1	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	RCA	10400698	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	MACMU|Ensembl=ENSMMUG00000016428|UniProtKB=F7GU00	Metabotropic glutamate receptor 1 isoform alpha	ISS	9407094	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00047	PDGF signaling pathway	P01161	Raf	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P04393	Ras Pathway	P04574	PLD	ORYSJ|EnsemblGenome=OS06G0604300|UniProtKB=Q69X21	Phospholipase D	IDA	14581626	PubMed	PTHR18896:SF59	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	PANTR|Ensembl=ENSPTRG00000000750|UniProtKB=H2PZ19	Uncharacterized protein	ISS	94365697	PubMed	PTHR11958:SF22	EXCITATORY AMINO ACID TRANSPORTER 5
P00048	PI3 kinase pathway	P01202	p85	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00057	Wnt signaling pathway	P01443	Phospholipase C	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00010	B cell activation	P00371	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04665	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04393	Ras Pathway	P04569	Cdc42	TAKRU|Ensembl=ENSTRUG00000008289|UniProtKB=H2T7U8	Uncharacterized protein	ISS	15723050	PubMed	PTHR24072:SF129	CDC42L PROTEIN
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	IDA	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12701063	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04395	Vasopressin synthesis	P04597	Signal Peptide	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00018	EGF receptor signaling pathway	P00543	ERK1-2	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05915	Opioid proenkephalin pathway	P05994	G-protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MOUSE|MGI=MGI=102705|UniProtKB=P63213	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00019	Endothelin signaling pathway	P00586	Gq	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00034	Integrin signalling pathway	P00928	alpha actinin	RAT|RGD=70907|UniProtKB=Q9Z1P2	Alpha-actinin-1	IPI	2116421	PubMed	PTHR43947:SF3	ALPHA-ACTININ-1
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	HUMAN|HGNC=7882|UniProtKB=Q04721	Neurogenic locus notch homolog protein 2	IDA	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P02723	Adenine and hypoxanthine salvage pathway	P02811	Adenosine deaminase	STRCO|EnsemblGenome=CAC33066|UniProtKB=Q9AK25	Adenosine deaminase 1	ISS			PTHR11409:SF43	ADENOSINE DEAMINASE
P00034	Integrin signalling pathway	P00931	Integrin beta	HUMAN|Ensembl=ENSG00000259753|UniProtKB=H3BM21	Integrin beta (Fragment)	IDA	4206165	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00057	Wnt signaling pathway	P01453	Ebi	TAKRU|Ensembl=ENSTRUG00000009728|UniProtKB=H2TID7	Uncharacterized protein (Fragment)	ISS	11389839	PubMed	PTHR22846:SF2	F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN TBL1X
P00023	General transcription regulation	P00664	TFIIH complex	PANTR|Ensembl=ENSPTRG00000017943|UniProtKB=P60027	General transcription factor IIH subunit 4	ISS			PTHR13152:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04398	p53 pathway feedback loops 2	P04651	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00865	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	7680960	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P04393	Ras Pathway	P04558	p38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00019	Endothelin signaling pathway	P00591	PLCbeta	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IGI	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00034	Integrin signalling pathway	P00916	Ras	CAEEL|WormBase=WBGene00002335|UniProtKB=P22981	Ras protein let-60	IPI	22022015	PubMed	PTHR24070:SF385	GTPASE HRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05734	Synaptic vesicle trafficking	P05780	Rab3A	MOUSE|MGI=MGI=97843|UniProtKB=P63011	Ras-related protein Rab-3A	ISS	9194562	PubMed	PTHR24073:SF532	RAS-RELATED PROTEIN RAB-3A
P00018	EGF receptor signaling pathway	P00559	MEK1-2	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	PANTR|Ensembl=ENSPTRG00000003983|UniProtKB=H2Q4A0	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P04393	Ras Pathway	P04541	p90RSK	CANLF|Ensembl=ENSCAFG00000013171|UniProtKB=E2RP04	Uncharacterized protein	ISS	2779569	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00924	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01153	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00047	PDGF signaling pathway	P01173	STAT	RAT|RGD=1309063|UniProtKB=Q1KQ07	Signal transducer and activator of transcription	ISS	14598258	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00049	Parkinson disease	P01238	14-3-3	CHICK|Ensembl=ENSGALG00000006743|UniProtKB=Q5ZKJ2	Uncharacterized protein	ISS	6756037	gi	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00053	T cell activation	P01324	rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04398	p53 pathway feedback loops 2	P04665	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01238	14-3-3	DANRE|ZFIN=ZDB-GENE-011115-1|UniProtKB=Q6PC29	14-3-3 protein gamma-1	ISS	22165492	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	PANTR|Ensembl=ENSPTRG00000005124|UniProtKB=H2Q6A8	Serine hydroxymethyltransferase	ISS			PTHR11680:SF17	SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL
P00054	Toll receptor signaling pathway	P01368	MKK2	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00019	Endothelin signaling pathway	P00586	Gq	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00022	General transcription by RNA polymerase I	P00657	TBP	PANTR|Gene=TBPL2|UniProtKB=A6H907	TATA box-binding protein-like protein 2	ISS	600075	OMIM	PTHR10126:SF34	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 2
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00053	T cell activation	P01311	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IPI	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	IGI	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=107924|UniProtKB=Q64527	Protein Wnt-8a	TAS	8717036	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	HUMAN|HGNC=17296|UniProtKB=Q7LG56	Ribonucleoside-diphosphate reductase subunit M2 B	ISS			PTHR23409:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 B
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00021	FGF signaling pathway	P00624	14-3-3	MONDO|Ensembl=ENSMODG00000015951|UniProtKB=F7FRT9	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	MACMU|Ensembl=ENSMMUG00000010173|UniProtKB=F7AGU8	Presenilin	ISS	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	YEAST|SGD=S000005627|UniProtKB=P01119	Ras-like protein 1	ISS	7997267	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	BOVIN|Ensembl=ENSBTAG00000000219|UniProtKB=F1MCL3	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00045	Notch signaling pathway	P01104	Serrate	HUMAN|HGNC=6188|UniProtKB=P78504	Protein jagged-1	IGI	12826675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00034	Integrin signalling pathway	P00925	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P02788	Xanthine and guanine salvage pathway	P03250	Guanosine phosphorylase	THEMA|EnsemblGenome=TM_1596|UniProtKB=Q9X1T2	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	DANRE|ZFIN=ZDB-GENE-030131-688|UniProtKB=Q7T2P7	Glutamine synthetase	ISS			PTHR20852:SF43	GLUTAMINE SYNTHETASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P04393	Ras Pathway	P04565	MKK4/7	CANLF|Ensembl=ENSCAFG00000017851|UniProtKB=F1PBB6	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	METAC|EnsemblGenome=MA_4331|UniProtKB=Q8TI26	TATA-box-binding protein 1	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P02723	Adenine and hypoxanthine salvage pathway	P02804	Hypoxanthine phosphoribosyl transferase	STRCO|Gene=CAB42758|UniProtKB=Q9X8I5	Putative hypoxanthine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00056	VEGF signaling pathway	P01407	Erk	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00035	Interferon-gamma signaling pathway	P00956	SOCS	MOUSE|MGI=MGI=2651588|UniProtKB=Q8VHQ2	Suppressor of cytokine signaling 7	TAS	12645661	PubMed	PTHR45052:SF1	SUPPRESSOR OF CYTOKINE SIGNALING 7
P04393	Ras Pathway	P04572	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00807	Actin	DICPU|Gene=DICPUDRAFT_90232|UniProtKB=F1A175	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	RCA	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P06959	CCKR signaling map	G07279	TACR1	HUMAN|HGNC=11526|UniProtKB=P25103	Substance-P receptor	RCA	20007404	PubMed	PTHR43919:SF2	SUBSTANCE-P RECEPTOR
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00052	TGF-beta signaling pathway	P01287	BAMBI	CANLF|Ensembl=ENSCAFG00000030262|UniProtKB=J9NW61	BMP and activin membrane-bound inhibitor homolog	ISS	10519551	PubMed	PTHR15505:SF1	BMP AND ACTIVIN MEMBRANE-BOUND INHIBITOR HOMOLOG
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	BOVIN|Ensembl=ENSBTAG00000003417|UniProtKB=Q2KJ16	Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	ISS	1370475	PubMed	PTHR44087:SF2	PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, LIVER/TESTIS ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MOUSE|MGI=MGI=87905|UniProtKB=P68033	Actin, alpha cardiac muscle 1	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00048	PI3 kinase pathway	P01185	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00048	PI3 kinase pathway	P01203	p101	PANTR|Ensembl=ENSPTRG00000008751|UniProtKB=H2QC89	Uncharacterized protein	ISS	129387	gi	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05943	GRK2	MACMU|Ensembl=ENSMMUG00000015925|UniProtKB=F7AL30	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P00036	Interleukin signaling pathway	P00996	STAT	MACMU|Ensembl=ENSMMUG00000010707|UniProtKB=F7G8G5	Signal transducer and activator of transcription	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	MACMU|Ensembl=ENSMMUG00000004229|UniProtKB=F6SNN4	Uncharacterized protein	ISS			PTHR22778:SF16	DIHYDROFOLATE REDUCTASE
P00012	Cadherin signaling pathway	P00474	Wnt	ANOGA|EnsemblGenome=AGAP009731|UniProtKB=Q7PM77	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF98	PROTEIN WNT-RELATED
P00019	Endothelin signaling pathway	P00589	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	IDA	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CAEBR|Gene=CBG18256|UniProtKB=A8XS95	Protein CBR-ACT-5	ISS	14684598	PubMed	PTHR11937:SF352	ACTIN
P05918	p38 MAPK pathway	P06020	p38delta	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00049	Parkinson disease	P01215	Syntaxin	ORYSJ|EnsemblGenome=OS01G0254900|UniProtKB=Q9S7H0	Os01g0254900 protein	IPI			PTHR19957:SF38	T-SNARE DOMAIN-CONTAINING PROTEIN 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00899	IRS 1-4	MACMU|Ensembl=ENSMMUG00000019467|UniProtKB=F6SUL3	Uncharacterized protein	ISS	5031805	gi	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00019	Endothelin signaling pathway	P00590	IP3 R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=4599|UniProtKB=Q14831	Metabotropic glutamate receptor 7	IDA	11431030	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	MOUSE|MGI=MGI=96610|UniProtKB=P09055	Integrin beta-1	ISS	10706722	PubMed	PTHR10082:SF28	INTEGRIN BETA-1
P00048	PI3 kinase pathway	P01199	Galpha	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00029	Huntington disease	G01533	Bax	MACMU|Ensembl=ENSMMUG00000003907|UniProtKB=F6ZV96	Apoptosis regulator BAX isoform alpha	ISS	8358790	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P06664	Gonadotropin-releasing hormone receptor pathway	P06768	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	RCA	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04395	Vasopressin synthesis	P04593	Glycopeptide	MACMU|Ensembl=ENSMMUG00000010678|UniProtKB=F7AXI7	Uncharacterized protein	ISS	9756087	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00047	PDGF signaling pathway	P01163	c-Jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	CHICK|Ensembl=ENSGALG00000001334|UniProtKB=F1NLV4	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	4506785	gi	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00005	Angiogenesis	P00221	JNK1	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00009	Axon guidance mediated by netrin	P00366	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	10891487	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	MONDO|Ensembl=ENSMODG00000011791|UniProtKB=F7CBU9	Phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00007	Axon guidance mediated by semaphorins	P00341	Rho	PANTR|Ensembl=ENSPTRG00000014922|UniProtKB=H2QML4	Uncharacterized protein	ISS	12169092	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	CHICK|Ensembl=ENSGALG00000012617|UniProtKB=Q06900	Receptor protein serine/threonine kinase	TAS	10683140	PubMed	PTHR23255:SF61	TGF-BETA RECEPTOR TYPE-1
P00019	Endothelin signaling pathway	P00566	ERK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	IGI	12787066	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00053	T cell activation	P01330	IKK	MOUSE|MGI=MGI=1338071|UniProtKB=O88351	Inhibitor of nuclear factor kappa-B kinase subunit beta	IGI	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00036	Interleukin signaling pathway	P00996	STAT	BOVIN|Ensembl=ENSBTAG00000006335|UniProtKB=F1MGJ4	Signal transducer and activator of transcription	ISS	8085155	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00036	Interleukin signaling pathway	P00990	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05731	GABA-B receptor II signaling	P05752	PKA	DICDI|dictyBase=DDB_G0283907|UniProtKB=P34099	cAMP-dependent protein kinase catalytic subunit	RCA	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00056	VEGF signaling pathway	P01411	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00004	Alzheimer disease-presenilin pathway	P00149	Pen-2	PANTR|Ensembl=ENSPTRG00000029038|UniProtKB=H2QG41	Presenilin enhancer 2 homolog	ISS	12110170	PubMed	PTHR16318:SF0	GAMMA-SECRETASE SUBUNIT PEN-2
P00018	EGF receptor signaling pathway	P00554	Shc	CANLF|Ensembl=ENSCAFG00000002201|UniProtKB=F1PPW0	Uncharacterized protein	ISS	8760305	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05915	Opioid proenkephalin pathway	P05991	Enkephalin	RAT|RGD=68946|UniProtKB=P04094	Proenkephalin-A	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00058	mRNA splicing	P01476	U4	MACMU|Ensembl=ENSMMUG00000016301|UniProtKB=F7GUG7	Uncharacterized protein	ISS	12875835	PubMed	PTHR14212:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3
P00054	Toll receptor signaling pathway	P01343	IRAK1	MACMU|Ensembl=ENSMMUG00000018703|UniProtKB=F6WX15	Uncharacterized protein	ISS	96180673	PubMed	PTHR24419:SF1	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	RAT|RGD=2028|UniProtKB=P38445	Activin receptor type-2B	TAS	9395284	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DAPPU|EnsemblGenome=DAPPUDRAFT_59367|UniProtKB=E9H7Z0	Guanine nucleotide-binding protein G(O) subunit alpha 1	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00009	Axon guidance mediated by netrin	P00364	cdc42	TAKRU|Ensembl=ENSTRUG00000008289|UniProtKB=H2T7U8	Uncharacterized protein	ISS	15723050	PubMed	PTHR24072:SF129	CDC42L PROTEIN
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00047	PDGF signaling pathway	P01147	Nck	MACMU|Ensembl=ENSMMUG00000001390|UniProtKB=F7D094	Uncharacterized protein	ISS	12874226	PubMed	PTHR44108:SF1	CYTOPLASMIC PROTEIN NCK2
P00037	Ionotropic glutamate receptor pathway	P01018	Glu1	MOUSE|MGI=MGI=95808|UniProtKB=P23818	Glutamate receptor 1	ISS	12941441	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00053	T cell activation	P01318	PKC-theta	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	DROME|FlyBase=FBgn0264000|UniProtKB=M9PHV5	Glutamate receptor IB, isoform B	ISS	8804111	PubMed	PTHR18966:SF270	GLUTAMATE RECEPTOR 1-RELATED
P00029	Huntington disease	P00778	NMDA receptor	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00021	FGF signaling pathway	P00643	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00790	beta-Tubulin	BOVIN|Ensembl=ENSBTAG00000004624|UniProtKB=E1B953	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00057	Wnt signaling pathway	P01443	Phospholipase C	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00023	General transcription regulation	P00660	RNA Polymerase II	DROME|FlyBase=FBgn0037121|UniProtKB=Q9VNZ3	GM03174p	ISS	606023	OMIM	PTHR10917:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	TAKRU|Ensembl=ENSTRUG00000015938|UniProtKB=H2UUX5	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00005	Angiogenesis	P00236	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	HUMAN|HGNC=1954|UniProtKB=P08912	Muscarinic acetylcholine receptor M5	TAS	10069496	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MOUSE|MGI=MGI=1346873|UniProtKB=Q61083	Mitogen-activated protein kinase kinase kinase 2	ISS	21735556	gi	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	9395335	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00046	Oxidative stress response	P01135	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	TAS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=97614|UniProtKB=Q8R3B1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	12860966	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	ARATH|TAIR=AT1G55970|UniProtKB=Q9LG11	Histone acetyltransferase HAC4	ISS	10823891	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00003	Alzheimer disease-amyloid secretase pathway	P00093	Tip60	PANTR|Ensembl=ENSPTRG00000006842|UniProtKB=H2Q921	Uncharacterized protein	ISS			PTHR12345:SF12	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04396	Vitamin D metabolism and pathway	P04604	FdxR	ARATH|TAIR=AT4G32360|UniProtKB=Q8W3L1	NADPH:adrenodoxin oxidoreductase, mitochondrial	ISS			PTHR11938:SF91	NADPH:ADRENODOXIN OXIDOREDUCTASE, MITOCHONDRIAL
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MOUSE|MGI=MGI=87893|UniProtKB=P02716	Acetylcholine receptor subunit delta	IC	85203892	PubMed	PTHR18945:SF61	ACETYLCHOLINE RECEPTOR SUBUNIT DELTA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P02738	De novo purine biosynthesis	P02906	N5-carboxyaminoimidazole ribonucleotide synthase	FUSNN|EnsemblGenome=FN0989|UniProtKB=Q8REV0	N5-carboxyaminoimidazole ribonucleotide mutase	ISS			PTHR23046:SF2	N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE MUTASE
P00057	Wnt signaling pathway	P01440	Cadherin	CANLF|Ensembl=ENSCAFG00000017514|UniProtKB=E2REK7	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF40	PROTOCADHERIN-19
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	TAS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MOUSE|MGI=MGI=1202395|UniProtKB=O70138	Neutrophil collagenase	TAS	12834808	PubMed	PTHR10201:SF137	NEUTROPHIL COLLAGENASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	ISS	11889126	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000023940|UniProtKB=F6RFW8	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00059	p53 pathway	P04633	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00010	B cell activation	P00391	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00371	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00030	Hypoxia response via HIF activation	P00814	P300	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	CANLF|Ensembl=ENSCAFG00000006455|UniProtKB=E2R5N5	Uncharacterized protein	ISS	99239941	PubMed	PTHR10539:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00049	Parkinson disease	P01236	Casein kinase II	DROME|FlyBase=FBgn0264492|UniProtKB=P08181	Casein kinase II subunit alpha	ISS	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00029	Huntington disease	G01535	PIG3	BOVIN|Ensembl=ENSBTAG00000007390|UniProtKB=F1MUP9	Uncharacterized protein	ISS	12932731	PubMed	PTHR44054:SF1	SYNAPTIC VESICLE MEMBRANE PROTEIN VAT-1 HOMOLOG
P04393	Ras Pathway	P04556	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P04393	Ras Pathway	P04547	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000010526|UniProtKB=F7B1S0	Uncharacterized protein	ISS			PTHR11824:SF7	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00053	T cell activation	P01312	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	RAT|RGD=1304556|UniProtKB=P63259	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P02785	Valine biosynthesis	P03216	Acetolactate synthase	PANTR|Ensembl=ENSPTRG00000010614|UniProtKB=H2QFL7	IlvB (Bacterial acetolactate synthase)-like	ISS			PTHR18968:SF155	ACETOLACTATE SYNTHASE-LIKE PROTEIN
P00034	Integrin signalling pathway	P00907	ERK	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	ISS			PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05918	p38 MAPK pathway	P06025	SRF	RAT|RGD=1559787|UniProtKB=D3ZHH8	Protein Srf	ISS	15326221	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01316	MHC-antigen	BOVIN|Ensembl=ENSBTAG00000006490|UniProtKB=F1MHT7	Uncharacterized protein	ISS	73139	PubMed	PTHR19944:SF44	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DO ALPHA CHAIN
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	DICDI|dictyBase=DDB_G0273069|UniProtKB=P22887	Nucleoside diphosphate kinase, cytosolic	ISS			PTHR11349:SF64	NUCLEOSIDE DIPHOSPHATE KINASE HOMOLOG 5
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00589	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04397	p53 pathway by glucose deprivation	P04638	mTOR	DROME|FlyBase=FBgn0021796|UniProtKB=Q9VK45	Target of rapamycin	ISS	14526383	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00052	TGF-beta signaling pathway	P01275	P38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05916	Opioid prodynorphin pathway	P05999	provasopressin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00014	Cholesterol biosynthesis	P00497	Anosterol synthase	NEUCR|Gene=NCU01119|UniProtKB=Q1K768	Terpene cyclase/mutase family member	ISS	P38604	SPACC	PTHR11764:SF20	LANOSTEROL SYNTHASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	TAKRU|Ensembl=ENSTRUG00000016101|UniProtKB=H2UW32	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00047	PDGF signaling pathway	P01153	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00559	MEK1-2	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8440264	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06859	GATA2/4	MOUSE|MGI=MGI=95662|UniProtKB=O09100	Endothelial transcription factor GATA-2	RCA			PTHR10071:SF149	ENDOTHELIAL TRANSCRIPTION FACTOR GATA-2
P00006	Apoptosis signaling pathway	P00321	HSP70	DANRE|ZFIN=ZDB-GENE-990415-92|UniProtKB=Q90473	Heat shock cognate 71 kDa protein	ISS	12150907	PubMed	PTHR19375:SF239	HEAT SHOCK COGNATE 71 KDA PROTEIN
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00936	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	PSEAE|EnsemblGenome=PA5508|UniProtKB=Q9HT65	Probable glutamine synthetase	ISS			PTHR43785:SF2	TYPE-1 GLUTAMINE SYNTHETASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000012036|UniProtKB=F7ALP1	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000015178|UniProtKB=F6WI86	Neural cadherin	ISS	13678586	PubMed	PTHR24027:SF79	CADHERIN-2
P00052	TGF-beta signaling pathway	P01275	P38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	TAS	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	RCA	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	G01532	PolyQ HTT	HUMAN|HGNC=4851|UniProtKB=P42858	Huntingtin	TAS	7620118	PubMed	PTHR10170:SF10	HUNTINGTIN
P00012	Cadherin signaling pathway	P00467	alpha-catenin	CHICK|Ensembl=ENSGALG00000002447|UniProtKB=E1C7M7	Uncharacterized protein	ISS	1904011	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00035	Interferon-gamma signaling pathway	P00956	SOCS	HUMAN|HGNC=19392|UniProtKB=Q8WXH5	Suppressor of cytokine signaling 4	TAS	10500304	PubMed	PTHR44282:SF2	SUPPRESSOR OF CYTOKINE SIGNALING 4
P00021	FGF signaling pathway	P00623	FGF	DANRE|ZFIN=ZDB-GENE-050221-6|UniProtKB=Q5TKR3	Fibroblast growth factor	ISS	11376006	PubMed	PTHR11486:SF17	FIBROBLAST GROWTH FACTOR 12
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05918	p38 MAPK pathway	P06031	p38alpha	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	RCA	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00006	Apoptosis signaling pathway	P00310	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	THEMA|EnsemblGenome=TM_1096|UniProtKB=Q9X0I1	Adenylosuccinate synthetase	IEP	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00034	Integrin signalling pathway	P00948	Rho	RAT|RGD=1359690|UniProtKB=Q6SA80	Rho-related GTP-binding protein RhoE	ISS	11973360	PubMed	PTHR24072:SF24	RHO-RELATED GTP-BINDING PROTEIN RHOE
P00005	Angiogenesis	P00189	Fzd	CANLF|Ensembl=ENSCAFG00000008293|UniProtKB=E2R9M9	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF22	FRIZZLED-3
P00024	Glycolysis	P00674	Phosphoglucose isomerase	MOUSE|MGI=MGI=95797|UniProtKB=P06745	Glucose-6-phosphate isomerase	RCA			PTHR11469:SF4	GLUCOSE-6-PHOSPHATE ISOMERASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00321	HSP70	DANRE|ZFIN=ZDB-GENE-040426-1221|UniProtKB=Q6PGX4	Heat shock cognate 71 kDa protein	ISS	12150907	PubMed	PTHR19375:SF310	HEAT SHOCK COGNATE 71 KDA PROTEIN
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02788	Xanthine and guanine salvage pathway	P03249	Guanine deaminase	DROME|FlyBase=FBgn0261436|UniProtKB=Q9VMY9	Dihydropterin deaminase	ISS			PTHR11271:SF6	GUANINE DEAMINASE
P00036	Interleukin signaling pathway	P00990	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Ensembl=ENSCAFG00000000332|UniProtKB=F1P8E3	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00020	FAS signaling pathway	P00615	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	XENTR|Xenbase=XB-GENE-6469705|UniProtKB=Q6P8G3	Actin, alpha sarcomeric/skeletal	ISS	10974003	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00780	Microtubule	TAKRU|Ensembl=ENSTRUG00000005300|UniProtKB=H2SJZ5	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00010	B cell activation	P00379	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00048	PI3 kinase pathway	P01192	p110	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02744	Fructose galactose metabolism	P02960	Galactokinase	HUMAN|HGNC=4118|UniProtKB=P51570	Galactokinase	NAS	12003984	gi	PTHR10457:SF6	GALACTOKINASE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	ORYSJ|EnsemblGenome=OS01G0654100|UniProtKB=Q5VPD3	CTP synthase	ISS			PTHR11550:SF10	SUBFAMILY NOT NAMED
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MONDO|Ensembl=ENSMODG00000014746|UniProtKB=F6YN64	Uncharacterized protein (Fragment)	ISS	12941441	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	IDA	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00977	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=619858|UniProtKB=P70579	Metabotropic glutamate receptor 8	IDA	12351712	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BOVIN|Ensembl=ENSBTAG00000014614|UniProtKB=P62739	Actin, aortic smooth muscle	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	BOVIN|Ensembl=ENSBTAG00000019336|UniProtKB=F1MMW6	Uncharacterized protein	ISS	11212302	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	MACMU|Ensembl=ENSMMUG00000028962|UniProtKB=F7EWG5	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF322	SUBFAMILY NOT NAMED
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000002349|UniProtKB=P61267	Syntaxin-1B	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00006	Apoptosis signaling pathway	P00269	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	21071228	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04398	p53 pathway feedback loops 2	P04665	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00029	Huntington disease	P00790	beta-Tubulin	BOVIN|Ensembl=ENSBTAG00000021013|UniProtKB=Q3ZBU7	Tubulin beta-4A chain	ISS	9454836	PubMed	PTHR11588:SF253	TUBULIN BETA-4A CHAIN
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CHICK|Ensembl=ENSGALG00000015434|UniProtKB=F1NU20	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	TAS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	RCA	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00547	PP2A	RAT|RGD=6503746|UniProtKB=Q80W83	Protein LOC100909468	ISS	10092233	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00845	Cyclooxygenase	MOUSE|MGI=MGI=97798|UniProtKB=Q05769	Prostaglandin G/H synthase 2	IDA	12163371	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000003043|UniProtKB=P63212	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P05913	Enkephalin release	P05974	G-Protein (i)	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00036	Interleukin signaling pathway	P00964	p90RSK	RAT|RGD=1563860|UniProtKB=D3Z8E0	Ribosomal protein S6 kinase	ISS	10558991	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DANRE|ZFIN=ZDB-GENE-041001-104|UniProtKB=Q5TZD4	Protein kinase C	ISS	11880265	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00049	Parkinson disease	P01234	GRK	PANTR|Ensembl=ENSPTRG00000014187|UniProtKB=H2R714	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Ensembl=ENSPTRG00000004233|UniProtKB=H2Q4N9	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CAEBR|Gene=CBG14305|UniProtKB=A8XJQ6	cAMP-dependent protein kinase, catalytic subunit-like	ISS	1319556	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P05731	GABA-B receptor II signaling	P05752	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	11035810	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00021	FGF signaling pathway	P00628	JNK1-3	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IGI	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	MOUSE|MGI=MGI=106677|UniProtKB=Q8BRU6	Synaptic vesicular amine transporter	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DANRE|ZFIN=ZDB-GENE-041001-104|UniProtKB=Q5TZD4	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P06664	Gonadotropin-releasing hormone receptor pathway	P06779	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	RCA	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00018	EGF receptor signaling pathway	P00546	GAP	ANOGA|EnsemblGenome=AGAP002729|UniProtKB=Q7QCN5	AGAP002729-PA	ISS	21296043	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=1305941|UniProtKB=F1M324	Phosphoinositide phospholipase C	ISS			PTHR10336:SF84	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	IDA	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00243	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00035	Interferon-gamma signaling pathway	P00956	SOCS	MACMU|Ensembl=ENSMMUG00000020531|UniProtKB=F7D8G7	Uncharacterized protein	ISS	15032587	PubMed	PTHR45052:SF1	SUPPRESSOR OF CYTOKINE SIGNALING 7
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00586	Gq	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-050417-59|UniProtKB=Q15KE4	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00049	Parkinson disease	P01238	14-3-3	CANLF|Ensembl=ENSCAFG00000009514|UniProtKB=F1PKW7	Uncharacterized protein	ISS	12618428	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IDA	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05916	Opioid prodynorphin pathway	P06002	G-protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	HUMAN|HGNC=1389|UniProtKB=Q00975	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	14507926	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	TAS	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	MACMU|Ensembl=ENSMMUG00000019999|UniProtKB=F7FNE2	Uncharacterized protein	ISS	12135927	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00558	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IGI	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02748	Isoleucine biosynthesis	P02997	Acetolactate synthase	MOUSE|MGI=MGI=1351911|UniProtKB=Q8BU33	Acetolactate synthase-like protein	ISS			PTHR18968:SF155	ACETOLACTATE SYNTHASE-LIKE PROTEIN
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BOVIN|Gene=ACTB|UniProtKB=P60712	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	RAT|RGD=71009|UniProtKB=P21932	Adenylate cyclase type 3	IGI	2255909	PubMed	PTHR11920:SF291	ADENYLATE CYCLASE TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	HUMAN|HGNC=7165|UniProtKB=Q99542	Matrix metalloproteinase-19	TAS	12834808	PubMed	PTHR10201:SF166	MATRIX METALLOPROTEINASE-19
P00059	p53 pathway	P04634	Cdc2	MACMU|Ensembl=ENSMMUG00000019876|UniProtKB=F7EBT6	Uncharacterized protein	ISS			PTHR24056:SF334	CYCLIN-DEPENDENT KINASE 1
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	PANTR|Ensembl=ENSPTRG00000019310|UniProtKB=H2QUS4	C-C motif chemokine	ISS	12689651	PubMed	PTHR12015:SF73	C-C MOTIF CHEMOKINE 26
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	CANLF|Ensembl=ENSCAFG00000000557|UniProtKB=J9P9W3	Uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF151	CASEIN KINASE I ISOFORM GAMMA-3
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00019	Endothelin signaling pathway	P00570	PKA	DROME|FlyBase=FBgn0000489|UniProtKB=P16912	Protein kinase DC2	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00029	Huntington disease	P00772	FIP-2	RAT|RGD=628886|UniProtKB=Q8R5M4	Optineurin	TAS			PTHR31553:SF2	OPTINEURIN
P00048	PI3 kinase pathway	P01177	P110ACT	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Ensembl=ENSPTRG00000000543|UniProtKB=H2PYN8	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00029	Huntington disease	P00793	Arfaptin-2	MOUSE|MGI=MGI=1924182|UniProtKB=Q8K221	Arfaptin-2	ISS	11854752	PubMed	PTHR12141:SF3	ARFAPTIN-2
P00034	Integrin signalling pathway	P00907	ERK	HUMAN|HGNC=6854|UniProtKB=Q9Y2U5	Mitogen-activated protein kinase kinase kinase 2	IC			PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00056	VEGF signaling pathway	P01423	p38MAPK	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	ISS	10995439	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00049	Parkinson disease	P01210	UCH-L1	MACMU|Ensembl=ENSMMUG00000013071|UniProtKB=F7H5G4	Ubiquitin carboxyl-terminal hydrolase	ISS	12408865	PubMed	PTHR10589:SF19	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00552	Ras	NEUCR|EnsemblGenome=EFNCRG00000008769|UniProtKB=P22126	Protein ras-1	ISS	7997267	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00047	PDGF signaling pathway	P01160	IP3 receptor	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00034	Integrin signalling pathway	P00936	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IPI	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	TAKRU|Ensembl=ENSTRUG00000005447|UniProtKB=P68142	Actin, cytoplasmic 1	IDA	10974003	PubMed	PTHR11937:SF354	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04556	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00011	Blood coagulation	P00443	Fibrin polymer cross-linked	PANTR|Ensembl=ENSPTRG00000016535|UniProtKB=H2QQB5	Uncharacterized protein	ISS	6575700	PubMed	PTHR19143:SF232	FIBRINOGEN ALPHA CHAIN
P00018	EGF receptor signaling pathway	P00547	PP2A	MACMU|Ensembl=ENSMMUG00000020819|UniProtKB=F7HSM1	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=109356|UniProtKB=O09044	Synaptosomal-associated protein 23	IC	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=104785|UniProtKB=Q64331	Unconventional myosin-VI	IC			PTHR13140:SF706	UNCONVENTIONAL MYOSIN-VI
P06209	ALP23B signaling pathway	P06220	BABO	DROME|FlyBase=FBgn0011300|UniProtKB=A1Z7L8	Receptor protein serine/threonine kinase	IEA	9395284	PubMed	PTHR23255:SF71	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00004	Alzheimer disease-presenilin pathway	P00127	APP	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=69279|UniProtKB=Q9R0T4	Cadherin-1	IDA	8120095	PubMed	PTHR24027:SF319	CADHERIN-1
P02742	Tetrahydrofolate biosynthesis	P02951	GTP cyclohydrolase	YEAST|SGD=S000003499|UniProtKB=P51601	GTP cyclohydrolase 1	ISS			PTHR11109:SF0	GTP CYCLOHYDROLASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	IDA	93028473	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00053	T cell activation	P01294	NFAT	CANLF|Ensembl=ENSCAFG00000011625|UniProtKB=F1PDD9	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	IXOSC|EnsemblGenome=ISCW024111|UniProtKB=B7PBG2	Actin, putative (Fragment)	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00023	General transcription regulation	P00668	TFIIB	ARATH|TAIR=AT3G10330|UniProtKB=Q9SS44	Transcription initiation factor IIB-2	ISS			PTHR11618:SF37	CYCLIN FAMILY PROTEIN-RELATED
P00021	FGF signaling pathway	P00632	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P06002	G-protein	CAEEL|WormBase=WBGene00001648|UniProtKB=P51875	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00560	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	NEUCR|EnsemblGenome=EFNCRG00000003893|UniProtKB=P78711	Actin	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00049	Parkinson disease	P01221	Torsin A	CANLF|Ensembl=ENSCAFG00000019980|UniProtKB=F6V735	Uncharacterized protein	ISS	12421356	PubMed	PTHR10760:SF15	TORSIN-1A
P00053	T cell activation	P01307	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00039	Metabotropic glutamate receptor group III pathway	P01038	Vglut	BOVIN|Ensembl=ENSBTAG00000007036|UniProtKB=A4FV52	Vesicular glutamate transporter 1	ISS	15192755	PubMed	PTHR11662:SF138	VESICULAR GLUTAMATE TRANSPORTER 1
P00029	Huntington disease	P00778	NMDA receptor	MACMU|Ensembl=ENSMMUG00000019112|UniProtKB=F6T8S6	N-methyl D-aspartate receptor subtype 2B	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00006	Apoptosis signaling pathway	P00304	XIAP	DANRE|ZFIN=ZDB-GENE-030825-7|UniProtKB=X1WBS6	Uncharacterized protein	ISS			PTHR10044:SF115	BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 8-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ARATH|TAIR=AT2G42090|UniProtKB=P93738	Putative actin-9	IC	14684598	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00038	JAK/STAT signaling pathway	P01034	Jak	MOUSE|MGI=MGI=99928|UniProtKB=Q62137	Tyrosine-protein kinase JAK3	ISS	15179321	PubMed	PTHR24418:SF233	TYROSINE-PROTEIN KINASE JAK3
P00018	EGF receptor signaling pathway	P00543	ERK1-2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MONDO|Ensembl=ENSMODG00000004799|UniProtKB=F6VM87	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04397	p53 pathway by glucose deprivation	P04641	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00029	Huntington disease	P00788	Calpain	CHICK|Ensembl=ENSGALG00000010186|UniProtKB=P00789	Calpain-1 catalytic subunit	IDA	11675509	PubMed	PTHR10183:SF322	CALPAIN-11
P00053	T cell activation	P01322	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01275	P38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	PANTR|Ensembl=ENSPTRG00000005438|UniProtKB=H2RBJ1	Actin-related protein 2/3 complex subunit 3	ISS	12473693	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00004	Alzheimer disease-presenilin pathway	P00111	C99	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00056	VEGF signaling pathway	P01421	Rac	MOUSE|MGI=MGI=1920417|UniProtKB=Q9CXP4	Rho GTPase-activating protein 8	ISS			PTHR23176:SF3	PROTEIN PRR5-ARHGAP8-RELATED
P00005	Angiogenesis	P00220	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P05728	Anandamide degradation	P05741	FAAH	RAT|RGD=61808|UniProtKB=P97612	Fatty-acid amide hydrolase 1	RCA			PTHR11895:SF91	FATTY-ACID AMIDE HYDROLASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	CANLF|Ensembl=ENSCAFG00000000760|UniProtKB=E2R9L4	Uncharacterized protein	ISS	12878610	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	YEAST|SGD=S000001550|UniProtKB=P36010	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00006	Apoptosis signaling pathway	P00272	ASK1	BOVIN|Ensembl=ENSBTAG00000009065|UniProtKB=F1MXH6	Uncharacterized protein	ISS	12697749	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000026580|UniProtKB=F1MB93	Uncharacterized protein	ISS	12181435	PubMed	PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P04397	p53 pathway by glucose deprivation	P04640	p53	BOVIN|Ensembl=ENSBTAG00000001069|UniProtKB=P67939	Cellular tumor antigen p53	TAS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00036	Interleukin signaling pathway	P00976	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00053	T cell activation	P01315	Calcineurin	RAT|RGD=3383|UniProtKB=P20651	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	IGI	12091710	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	YEAST|SGD=S000000925|UniProtKB=P39962	Casein kinase I homolog 3	IDA	10617630	PubMed	PTHR11909:SF155	GILGAMESH, ISOFORM L
P00046	Oxidative stress response	P01135	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01457	GBeta	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IDA	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00925	MEK	DROME|FlyBase=FBgn0024326|UniProtKB=O61444	MAP kinase kinase 4, isoform A	IDA	7600581	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000035697|UniProtKB=Q28024	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P02742	Tetrahydrofolate biosynthesis	P02945	Dihydropteroate synthase	YEAST|SGD=S000005200|UniProtKB=P53848	Folic acid synthesis protein FOL1	ISS			PTHR20941:SF1	FOLIC ACID SYNTHESIS PROTEIN FOL1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00045	Notch signaling pathway	G01541	E(spl)-C genes	RAT|RGD=62082|UniProtKB=P35429	Transcription factor HES-2	IC			PTHR10985:SF15	TRANSCRIPTION FACTOR HES-2
P00019	Endothelin signaling pathway	P00577	PI3K	DROME|FlyBase=FBgn0015278|UniProtKB=Q7K3H0	LD28067p	IGI	8662856	PubMed	PTHR10048:SF64	LD28067P
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00777	CBP	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	IDA	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00052	TGF-beta signaling pathway	G01548	I-SMAD	RAT|RGD=1305069|UniProtKB=D3ZAQ2	Mothers against decapentaplegic homolog	ISS	9335505	PubMed	PTHR13703:SF28	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 6
P04395	Vasopressin synthesis	P04592	Exopeptidase	MONDO|Ensembl=ENSMODG00000002373|UniProtKB=F7G381	Uncharacterized protein	ISS	1778303	PubMed	PTHR11532:SF59	CARBOXYPEPTIDASE E
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CHICK|Gene=ACTG2|UniProtKB=P63270	Actin, gamma-enteric smooth muscle	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	ORNAN|Ensembl=ENSOANG00000007732|UniProtKB=F6PXH5	Uncharacterized protein (Fragment)	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04397	p53 pathway by glucose deprivation	P04641	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04565	MKK4/7	PANTR|Ensembl=ENSPTRG00000008783|UniProtKB=H2QCA7	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04396	Vitamin D metabolism and pathway	P04602	RXR	PANTR|Ensembl=ENSPTRG00000009120|UniProtKB=H2R9N8	Uncharacterized protein	ISS			PTHR24082:SF115	RETINOIC ACID RECEPTOR ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	HUMAN|HGNC=1388|UniProtKB=O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	15699344	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	ARATH|TAIR=AT3G17820|UniProtKB=Q9LVI8	Glutamine synthetase cytosolic isozyme 1-3	ISS			PTHR20852:SF79	GLUTAMINE SYNTHETASE CYTOSOLIC ISOZYME 1-1-RELATED
P00023	General transcription regulation	P00668	TFIIB	YEAST|SGD=S000006290|UniProtKB=P29055	Transcription initiation factor IIB	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P00036	Interleukin signaling pathway	P00985	PDK1/2	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	ISS	9094314	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	XENTR|Xenbase=XB-GENE-1005023|UniProtKB=Q6NVQ9	Fructose-bisphosphate aldolase	ISS	9804954	PubMed	PTHR11627:SF3	FRUCTOSE-BISPHOSPHATE ALDOLASE C
P00053	T cell activation	P01309	fos	MACMU|Ensembl=ENSMMUG00000010574|UniProtKB=A5A6H2	C-fos	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00017	DNA replication	P00535	5' to 3' Exoribonulcease	MACMU|Ensembl=ENSMMUG00000011405|UniProtKB=F6VZ85	Uncharacterized protein	ISS	99339991	PubMed	PTHR12341:SF41	5'-3' EXORIBONUCLEASE 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	TETTS|EnsemblGenome=TTHERM_00630500|UniProtKB=Q241P0	Calmodulin 1	ISS	10487978	PubMed	PTHR23050:SF245	AT16150P-RELATED
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	MACMU|Ensembl=ENSMMUG00000014509|UniProtKB=F7GE35	Inosine-5'-monophosphate dehydrogenase	ISS			PTHR11911:SF74	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8972|UniProtKB=O00750	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P05912	Dopamine receptor mediated signaling pathway	P05966	EPB41	MOUSE|MGI=MGI=95401|UniProtKB=P48193	Protein 4.1	ISS	12181426	PubMed	PTHR23280:SF12	PROTEIN 4.1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00057	Wnt signaling pathway	P01463	Kremen	CANLF|Ensembl=ENSCAFG00000019341|UniProtKB=E2R8I6	Uncharacterized protein	ISS			PTHR24269:SF15	KREMEN PROTEIN 2
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000022886|UniProtKB=E1BE29	Uncharacterized protein	ISS	15858232	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	RAT|RGD=620632|UniProtKB=Q9WVB9	Segment polarity protein dishevelled homolog DVL-1	TAS	12549854	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P00059	p53 pathway	P04609	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	129387	gi	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P05913	Enkephalin release	P05974	G-Protein (i)	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000039151|UniProtKB=F6R5F6	Uncharacterized protein	ISS	12441358	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00641	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00034	Integrin signalling pathway	P00948	Rho	ASHGO|EnsemblGenome=AGOS_ABR183W|UniProtKB=Q9HF54	GTP-binding protein RHO1	ISS	11973360	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00005	Angiogenesis	P00249	PAK	PANTR|Ensembl=ENSPTRG00000022187|UniProtKB=Q7YQL4	Serine/threonine-protein kinase PAK 3	ISS	7559398	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	1482697	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00052	TGF-beta signaling pathway	P01288	FKBP12	MACMU|Ensembl=ENSMMUG00000015996|UniProtKB=F7GBW1	Peptidyl-prolyl cis-trans isomerase	ISS			PTHR10516:SF301	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04397	p53 pathway by glucose deprivation	P04641	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00796	Kainate receptor	ORNAN|Ensembl=ENSOANG00000010302|UniProtKB=F6TDQ6	Uncharacterized protein	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00021	FGF signaling pathway	P00636	FGFR1-4	HUMAN|HGNC=3689|UniProtKB=P21802	Fibroblast growth factor receptor 2	IGI	10626794	PubMed	PTHR24416:SF130	FIBROBLAST GROWTH FACTOR RECEPTOR 2
P00021	FGF signaling pathway	P00628	JNK1-3	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	RAT|RGD=2027|UniProtKB=P63269	Actin, gamma-enteric smooth muscle	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	MACMU|Ensembl=ENSMMUG00000013140|UniProtKB=F6Z9H7	Uncharacterized protein	ISS			PTHR24361:SF345	SERINE/THREONINE-PROTEIN KINASE PAK 4
P00030	Hypoxia response via HIF activation	P00819	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00974	Receptor subunit beta	RAT|RGD=620026|UniProtKB=F1LRH7	Protein Il12rb2	ISS	8943050	PubMed	PTHR23036:SF79	INTERLEUKIN-12 RECEPTOR SUBUNIT BETA-2
P02752	Mannose metabolism	P03017	Mannose 6-P isomerase	HUMAN|HGNC=7216|UniProtKB=P34949	Mannose-6-phosphate isomerase	TAS	9525984	PubMed	PTHR10309:SF0	MANNOSE-6-PHOSPHATE ISOMERASE
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	ORYSJ|EnsemblGenome=OS05G0135700|UniProtKB=Q0DKY4	S-adenosylmethionine synthase 1	ISS			PTHR11964:SF34	SUBFAMILY NOT NAMED
P06664	Gonadotropin-releasing hormone receptor pathway	P06753	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	RCA	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00036	Interleukin signaling pathway	P00976	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00887	IRS 1-4	CANLF|Ensembl=ENSCAFG00000010397|UniProtKB=E2RDB5	Uncharacterized protein	ISS	1311924	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00045	Notch signaling pathway	P01103	Next	MOUSE|MGI=MGI=1095416|UniProtKB=Q9QXX0	Protein jagged-1	IPI	8955070	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00020	FAS signaling pathway	P00615	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	TAS	97102676	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00019	Endothelin signaling pathway	P00586	Gq	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00718	Phosphorylase a	HUMAN|HGNC=9726|UniProtKB=P11217	Glycogen phosphorylase, muscle form	IDA	4318782	PubMed	PTHR11468:SF13	GLYCOGEN PHOSPHORYLASE, MUSCLE FORM
P00059	p53 pathway	P01480	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P02729	Ascorbate degradation	P02849	L-xylulose kinase	STRCO|Gene=CAD55307|UniProtKB=Q8CJZ5	Putative sugar kinase	ISS			PTHR43095:SF5	SUBFAMILY NOT NAMED
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00049	Parkinson disease	P01224	UbcH7	CANLF|Ensembl=ENSCAFG00000015284|UniProtKB=E2RKT9	Uncharacterized protein	ISS	10888878	PubMed	PTHR24068:SF67	UBIQUITIN-CONJUGATING ENZYME E2 L3
P00034	Integrin signalling pathway	P00927	Rac	DICDI|dictyBase=DDB_G0293526|UniProtKB=P34149	Rho-related protein racC	IGI	12932731	PubMed	PTHR24072:SF117	RHO-RELATED PROTEIN RACC
P00010	B cell activation	P00381	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IGI	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00017	DNA replication	P00527	Histones	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g148952|UniProtKB=A7T7J5	Histone H3 (Fragment)	ISS	20448842	PubMed	PTHR11426:SF171	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01423	p38MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00012	Cadherin signaling pathway	P00471	Cadherin	BOVIN|Ensembl=ENSBTAG00000020657|UniProtKB=E1BKL9	Uncharacterized protein	ISS	8120095	PubMed	PTHR24026:SF42	PROTOCADHERIN FAT 1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00205	GAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00029	Huntington disease	P00780	Microtubule	CHICK|Ensembl=ENSGALG00000000059|UniProtKB=F1NMU4	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	RCA	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00005	Angiogenesis	P00248	Ang-1	PANTR|Ensembl=ENSPTRG00000020503|UniProtKB=H2QWK4	Angiopoietin 1	ISS	8980223	PubMed	PTHR19143:SF156	ANGIOPOIETIN-1
P00052	TGF-beta signaling pathway	P01289	I-Smads	BOVIN|Ensembl=ENSBTAG00000000625|UniProtKB=E1BH37	Mothers against decapentaplegic homolog	ISS	9335505	PubMed	PTHR13703:SF28	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 6
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000003399|UniProtKB=H2Q383	Phosphoinositide-3-kinase, class 2, alpha polypeptide	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	MOUSE|MGI=MGI=94926|UniProtKB=P51436	D(4) dopamine receptor	ISS	2039532	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MONDO|Ensembl=ENSMODG00000008382|UniProtKB=F7CDR6	Uncharacterized protein (Fragment)	ISS	11259487	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IDA	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00383	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	ISS	10553940	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00021	FGF signaling pathway	P00645	Rac	DICPU|Gene=DICPUDRAFT_92985|UniProtKB=F1A084	Putative uncharacterized protein rac1A	ISS	21127961	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00238	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000021442|UniProtKB=F7EAQ8	Muscarinic acetylcholine receptor	ISS			PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P06664	Gonadotropin-releasing hormone receptor pathway	P06852	nPKCs	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	RCA	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	CAEEL|WormBase=WBGene00002173|UniProtKB=Q9Y0A1	Inositol 1,4,5-trisphosphate receptor itr-1	IDA	1849282	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00053	T cell activation	P01307	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00018	EGF receptor signaling pathway	P00559	MEK1-2	YEAST|SGD=S000006061|UniProtKB=P32491	MAP kinase kinase MKK2/SSP33	ISS			PTHR24361:SF351	MAP KINASE KINASE MKK1/SSP32-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00857	IkappaB	RAT|RGD=3171|UniProtKB=Q63746	NF-kappa-B inhibitor alpha	ISS	10811867	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	RCA	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	MACMU|Ensembl=ENSMMUG00000009054|UniProtKB=F7F735	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MACMU|Ensembl=ENSMMUG00000013215|UniProtKB=F6X7X4	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF31	FRIZZLED-7
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	HUMAN|HGNC=1404|UniProtKB=O00305	Voltage-dependent L-type calcium channel subunit beta-4	IC			PTHR11824:SF7	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4
P00015	Circadian clock system	G01497	cry	MACMU|Ensembl=ENSMMUG00000002453|UniProtKB=F7HH05	Cryptochrome-2	ISS	10217146	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CAEEL|WormBase=WBGene00001681|UniProtKB=P54406	Guanine nucleotide-binding protein subunit gamma	IC	2122451	PubMed	PTHR13809:SF3	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA-RELATED
P00050	Plasminogen activating cascade	P01255	Plasminogen	HUMAN|HGNC=9071|UniProtKB=P00747	Plasminogen	IDA	4505881	gi	PTHR24261:SF6	PLASMINOGEN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	CHICK|Ensembl=ENSGALG00000001172|UniProtKB=P19439	Probable glutamate receptor	ISS	12941441	PubMed	PTHR18966:SF282	GLUTAMATE RECEPTOR-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IDA	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00564	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00049	Parkinson disease	P01208	Hsp70	TAKRU|Ensembl=ENSTRUG00000002095|UniProtKB=H2RXF2	Uncharacterized protein	IDA	12150907	PubMed	PTHR19375:SF256	HSP70 PROTEIN-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CHICK|Ensembl=ENSGALG00000017178|UniProtKB=F1N982	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	IDA	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	RAT|RGD=2850|UniProtKB=Q62758	5-hydroxytryptamine receptor 4	IDA	12898568	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00910	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8051109	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00577	PI3K	CAEEL|WormBase=WBGene00006932|UniProtKB=Q9TXI7	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	21924698	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P02723	Adenine and hypoxanthine salvage pathway	P02805	Adenine phosphorylase	ANOGA|EnsemblGenome=AGAP005945|UniProtKB=A4Q998	AGAP005945-PA	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P05913	Enkephalin release	P05977	G-Protein (s)	DICDI|dictyBase=DDB_G0277143|UniProtKB=P36408	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00007	Axon guidance mediated by semaphorins	P00340	Rac	CHICK|Ensembl=ENSGALG00000002859|UniProtKB=F6UBD2	Uncharacterized protein	ISS	9252344	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	DANRE|ZFIN=ZDB-GENE-030131-8013|UniProtKB=F1QBT6	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	HUMAN|HGNC=130|UniProtKB=P62736	Actin, aortic smooth muscle	IC	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04372	5-Hydroxytryptamine degredation	P04401	Monoamine Oxidase	MACMU|Ensembl=ENSMMUG00000011627|UniProtKB=F6ZN34	Uncharacterized protein	ISS			PTHR10742:SF21	L-AMINO-ACID OXIDASE
P00029	Huntington disease	P00807	Actin	YEAST|SGD=S000001855|UniProtKB=P60010	Actin	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06959	CCKR signaling map	P07088	RYR1/2/3	HUMAN|HGNC=10484|UniProtKB=Q92736	Ryanodine receptor 2	RCA	21786193	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00029	Huntington disease	P00811	Arp2/3 complex	MOUSE|MGI=MGI=1928896|UniProtKB=Q9R0Q6	Actin-related protein 2/3 complex subunit 1A	TAS	12963527	gi	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00019	Endothelin signaling pathway	P00566	ERK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	RAT|RGD=619729|UniProtKB=O88204	Low-density lipoprotein receptor-related protein 3	IDA	11907044	PubMed	PTHR44062:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 3
P00019	Endothelin signaling pathway	P00568	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	IGI	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IPI	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04556	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	RAT|RGD=2740|UniProtKB=Q62645	Glutamate receptor ionotropic, NMDA 2D	IC	11319238	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06831	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	RCA	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	HUMAN|HGNC=1392|UniProtKB=Q15878	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	11976940	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00056	VEGF signaling pathway	P01407	Erk	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	DANRE|ZFIN=ZDB-GENE-040426-2487|UniProtKB=Q803G3	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01161	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	PANTR|Ensembl=ENSPTRG00000006342|UniProtKB=H2Q8A8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00020	FAS signaling pathway	P00608	Pro-Caspase3	CANLF|Ensembl=ENSCAFG00000007750|UniProtKB=Q8MKI5	Caspase-3	IGI	9323209	PubMed	PTHR10454:SF198	CASPASE-3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ANOGA|EnsemblGenome=AGAP005913|UniProtKB=Q7Q6D2	AGAP005913-PA	IC	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00048	PI3 kinase pathway	P01194	S6K	CHICK|Ensembl=ENSGALG00000005198|UniProtKB=F1P4J0	Ribosomal protein S6 kinase	ISS	11861821	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00021	FGF signaling pathway	P00624	14-3-3	CHICK|Ensembl=ENSGALG00000006743|UniProtKB=Q5ZKJ2	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00023	General transcription regulation	P00660	RNA Polymerase II	ANOGA|EnsemblGenome=AGAP010064|UniProtKB=Q7PJW8	AGAP010064-PA	ISS	11313498	gi	PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P00057	Wnt signaling pathway	P01438	PP2A	TRIAD|EnsemblGenome=TriadG63380|UniProtKB=B3S653	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05730	Endogenous cannabinoid signaling	P05746	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00047	PDGF signaling pathway	P01162	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	RAT|RGD=2739|UniProtKB=Q00961	Glutamate receptor ionotropic, NMDA 2C	IC	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00034	Integrin signalling pathway	P00912	Arp2/3	BOVIN|Gene=ARPC5|UniProtKB=Q3SYX9	Actin-related protein 2/3 complex subunit 5	IPI	12932731	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P04393	Ras Pathway	P04578	Rho	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	ISS	11360179	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	DANRE|ZFIN=ZDB-GENE-031112-1|UniProtKB=B8JLS3	Uncharacterized protein	ISS			PTHR13140:SF721	MYOSIN-6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000007882|UniProtKB=G3X7Z2	Uncharacterized protein	ISS	14624853	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00001	Adrenaline and noradrenaline biosynthesis	P00065	DAT	MACMU|Ensembl=ENSMMUG00000005198|UniProtKB=Q7JHP9	Transporter	ISS	92107910	PubMed	PTHR11616:SF38	SODIUM-DEPENDENT DOPAMINE TRANSPORTER
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MOUSE|MGI=MGI=88396|UniProtKB=P12657	Muscarinic acetylcholine receptor M1	IDA	10069496	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00056	VEGF signaling pathway	P01417	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05730	Endogenous cannabinoid signaling	P05751	Galpha	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P06664	Gonadotropin-releasing hormone receptor pathway	G06889	5' LHbeta	MOUSE|MGI=MGI=96782|UniProtKB=O09108	Lutropin subunit beta	RCA			PTHR11515:SF11	LUTROPIN SUBUNIT BETA
P00048	PI3 kinase pathway	P01179	PKB	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	TAS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	DROME|FlyBase=FBgn0027343|UniProtKB=O77438	Frizzled-3	TAS	11212302	PubMed	PTHR11309:SF125	FRIZZLED-3
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000010521|UniProtKB=F7DQK7	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00005	Angiogenesis	P00227	PLA2	CANLF|Ensembl=ENSCAFG00000013778|UniProtKB=F6UQ33	Phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IGI	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	NEUCR|EnsemblGenome=EFNCRG00000001656|UniProtKB=Q9HE76	Adenylate kinase	ISS			PTHR23359:SF117	ADENYLATE KINASE 2, MITOCHONDRIAL
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	MACMU|Ensembl=ENSMMUG00000009054|UniProtKB=F7F735	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00047	PDGF signaling pathway	P01169	Vav	RAT|RGD=1565941|UniProtKB=F1LWB1	Protein Vav3	ISS	14623913	PubMed	PTHR22826:SF97	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3
P00018	EGF receptor signaling pathway	P00547	PP2A	HUMAN|HGNC=9311|UniProtKB=Q13362	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	ISS	8576224	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P05915	Opioid proenkephalin pathway	P05991	Enkephalin	BOVIN|Ensembl=ENSBTAG00000004924|UniProtKB=P01211	Proenkephalin-A	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00551	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05730	Endogenous cannabinoid signaling	P05751	Galpha	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00049	Parkinson disease	P01242	Casein kinase I	ARATH|TAIR=AT2G19470|UniProtKB=Q9ZUP4	At2g19470	IDA	11437445	PubMed	PTHR11909:SF298	CASEIN KINASE 1-LIKE PROTEIN 12-RELATED
P00018	EGF receptor signaling pathway	P00557	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=5289|UniProtKB=P28221	5-hydroxytryptamine receptor 1D	IDA	12441358	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00007	Axon guidance mediated by semaphorins	P00339	CRMP	MOUSE|MGI=MGI=1349764|UniProtKB=O35098	Dihydropyrimidinase-related protein 4	ISS			PTHR11647:SF55	DIHYDROPYRIMIDINASE-RELATED PROTEIN 4
P05916	Opioid prodynorphin pathway	P06002	G-protein	IXOSC|EnsemblGenome=ISCW009711|UniProtKB=B7Q3T6	THO complex subunit, putative	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04393	Ras Pathway	P04573	Elk-1	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	IDA	10487205	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=109356|UniProtKB=O09044	Synaptosomal-associated protein 23	IC	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	IC	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P02781	Threonine biosynthesis	P03189	Aspartate kinase	NEUCR|EnsemblGenome=EFNCRG00000003525|UniProtKB=Q7RZC2	Homoserine dehydrogenase	ISS			PTHR43070:SF3	HOMOSERINE DEHYDROGENASE
P00018	EGF receptor signaling pathway	P00539	14-3-3	MOUSE|MGI=MGI=891963|UniProtKB=P68254	14-3-3 protein theta	IGI	10407019	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000005792|UniProtKB=F6VTR8	Uncharacterized protein	ISS	12507995	PubMed	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MOUSE|MGI=MGI=96571|UniProtKB=Q04999	Inhibin beta B chain	ISS	9759503	PubMed	PTHR11848:SF29	INHIBIN BETA B CHAIN
P00038	JAK/STAT signaling pathway	P01034	Jak	PANTR|Ensembl=ENSPTRG00000010685|UniProtKB=H2R074	Tyrosine-protein kinase	ISS	15179321	PubMed	PTHR24418:SF233	TYROSINE-PROTEIN KINASE JAK3
P00030	Hypoxia response via HIF activation	P00819	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00570	PKA	NEUCR|EnsemblGenome=EFNCRG00000004240|UniProtKB=Q01386	cAMP-dependent protein kinase regulatory subunit	IGI	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IDA	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00005	Angiogenesis	P00256	PLC-gamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00006	Apoptosis signaling pathway	P00318	PKCs	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04393	Ras Pathway	P04569	Cdc42	XENTR|Xenbase=XB-GENE-967585|UniProtKB=Q28BZ0	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00053	T cell activation	P01322	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01154	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04395	Vasopressin synthesis	P04593	Glycopeptide	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	IC	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	DROME|FlyBase=FBgn0000117|UniProtKB=P18824	Armadillo segment polarity protein	ISS			PTHR23315:SF233	ARMADILLO SEGMENT POLARITY PROTEIN
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IDA			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00019	Endothelin signaling pathway	P00566	ERK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	IGI	10514528	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00010	B cell activation	P00385	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00054	Toll receptor signaling pathway	P01338	IkappaB	HUMAN|HGNC=7797|UniProtKB=P25963	NF-kappa-B inhibitor alpha	ISS	10811867	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00052	TGF-beta signaling pathway	P01284	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	CANLF|Ensembl=ENSCAFG00000018170|UniProtKB=E2RPM8	Tyrosine-protein kinase receptor	ISS	249616	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	IC	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00059	p53 pathway	G04694	p110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	DANRE|ZFIN=ZDB-GENE-051202-2|UniProtKB=Q6ZM67	Uncharacterized protein	ISS	92049750	PubMed	PTHR44391:SF3	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00190	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00005	Angiogenesis	P00221	JNK1	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00053	T cell activation	P01319	PAK	BOVIN|Ensembl=ENSBTAG00000010191|UniProtKB=Q08E52	Serine/threonine-protein kinase PAK 1	ISS	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04395	Vasopressin synthesis	P04597	Signal Peptide	MACMU|Ensembl=ENSMMUG00000010678|UniProtKB=F7AXI7	Uncharacterized protein	ISS	9756087	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00021	FGF signaling pathway	P00626	Spry	HUMAN|HGNC=11270|UniProtKB=O43597	Protein sprouty homolog 2	IGI	12402043	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P00009	Axon guidance mediated by netrin	P00363	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CHICK|Ensembl=ENSGALG00000019382|UniProtKB=E1BWK1	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00012	Cadherin signaling pathway	P00470	F-actin	SCHMA|EnsemblGenome=Smp_183710|UniProtKB=G4VLW1	Putative actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00010	B cell activation	P00371	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00041	Metabotropic glutamate receptor group I pathway	P01062	mGluR1	RAT|RGD=2742|UniProtKB=P23385	Metabotropic glutamate receptor 1	ISS	7476890	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	TAS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00006	Apoptosis signaling pathway	P00307	ELF2alpha	DANRE|ZFIN=ZDB-GENE-030131-526|UniProtKB=Q7ZWD3	Eif2s1l protein	ISS	10889505	PubMed	PTHR10602:SF0	EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1
P00025	Hedgehog signaling pathway	P00690	Cubitus interruptus	XENTR|Xenbase=XB-GENE-484855|UniProtKB=F6XFR9	Uncharacterized protein (Fragment)	ISS	9203143	PubMed	PTHR19818:SF5	TRANSCRIPTIONAL ACTIVATOR GLI3
P00029	Huntington disease	P00807	Actin	ORNAN|Ensembl=ENSOANG00000007581|UniProtKB=F6QWB7	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00053	T cell activation	P01294	NFAT	PANTR|Ensembl=ENSPTRG00000006218|UniProtKB=H2Q834	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8665|UniProtKB=Q9Y5I1	Protocadherin alpha-11	IDA	8120095	PubMed	PTHR24028:SF68	PROTOCADHERIN ALPHA-11
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00189	Fzd	MOUSE|MGI=MGI=1196625|UniProtKB=O70421	Frizzled-1	ISS	12549854	PubMed	PTHR11309:SF81	FRIZZLED-1
P02768	Proline biosynthesis	P03112	Glutamate semialdehyde dehydrogenase	THEMA|EnsemblGenome=TM_0293|UniProtKB=Q9WYC9	Gamma-glutamyl phosphate reductase	ISS			PTHR11063:SF8	DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE
P00055	Transcription regulation by bZIP transcription factor	P01392	TFIIH complex	MOUSE|MGI=MGI=1338799|UniProtKB=O70422	General transcription factor IIH subunit 4	ISS			PTHR13152:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04674	Mdm2	CANLF|Ensembl=ENSCAFG00000009669|UniProtKB=E2RDT3	Uncharacterized protein	ISS			PTHR13844:SF20	PROTEIN MDM4
P00046	Oxidative stress response	P01131	MKP5	HUMAN|HGNC=11447|UniProtKB=Q8WUJ0	Serine/threonine/tyrosine-interacting protein	ISS			PTHR10159:SF385	SERINE/THREONINE/TYROSINE-INTERACTING PROTEIN
P00036	Interleukin signaling pathway	P00966	mTOR	PANTR|Ensembl=ENSPTRG00000000142|UniProtKB=H2PY03	Uncharacterized protein	ISS	14526383	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00564	Rac	DICDI|dictyBase=DDB_G0268622|UniProtKB=P34145	Rho-related protein rac1B	IGI	21127961	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000004896|UniProtKB=F7C2C6	Uncharacterized protein (Fragment)	ISS	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00054	Toll receptor signaling pathway	P01369	MKK1	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	RCA			PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PLAF7|EnsemblGenome=PFA0190c|UniProtKB=Q8I2A2	Actin-related protein	ISS	14684598	PubMed	PTHR11937:SF46	ALPHA-CENTRACTIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00859	NFkappaB	MACMU|Ensembl=ENSMMUG00000002990|UniProtKB=F7GVV0	Uncharacterized protein	ISS	12574369	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MOUSE|MGI=MGI=1309999|UniProtKB=Q922R0	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00021	FGF signaling pathway	P00641	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00020	FAS signaling pathway	P00601	c-Jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	PANTR|Ensembl=ENSPTRG00000003795|UniProtKB=H2Q3X5	Muscarinic acetylcholine receptor	ISS	8100450	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05913	Enkephalin release	P05974	G-Protein (i)	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	HUMAN|HGNC=9441|UniProtKB=P51817	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02781	Threonine biosynthesis	P03192	Aspartate semialdehyde dehydrogenase	ARATH|TAIR=AT1G14810|UniProtKB=Q8VYI4	Aspartate semialdehyde dehydrogenase	ISS			PTHR10174:SF2	ASPARTATE-SEMIALDEHYDE DEHYDROGENASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IDA	176892	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00561	STAT	TAKRU|Ensembl=ENSTRUG00000015454|UniProtKB=H2URF8	Signal transducer and activator of transcription	ISS			PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P02747	Histidine biosynthesis	P02987	ATP phosphoribosyl transferase	SCHPO|PomBase=SPAC25G10.05c|UniProtKB=P40373	ATP phosphoribosyltransferase	ISS			PTHR21403:SF0	ATP PHOSPHORIBOSYLTRANSFERASE
P00019	Endothelin signaling pathway	P00572	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00019	Endothelin signaling pathway	P00566	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00048	PI3 kinase pathway	P01181	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00054	Toll receptor signaling pathway	P01352	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00059	p53 pathway	P01486	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01414	PLC-gamma	DROME|FlyBase=FBgn0003416|UniProtKB=Q9VXH3	Phosphoinositide phospholipase C	ISS			PTHR10336:SF91	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00036	Interleukin signaling pathway	P00965	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	IC	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00012	Cadherin signaling pathway	P00470	F-actin	TRIVA|Gene=TVAG_054030|UniProtKB=A2G1K5	Actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00036	Interleukin signaling pathway	P00974	Receptor subunit beta	HUMAN|HGNC=5971|UniProtKB=P42701	Interleukin-12 receptor subunit beta-1	TAS	8958915	PubMed	PTHR23036:SF51	INTERLEUKIN-12 RECEPTOR SUBUNIT BETA-1
P05916	Opioid prodynorphin pathway	P06000	vasopressin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00047	PDGF signaling pathway	P01168	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	12660731	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00718	Phosphorylase a	BOVIN|Ensembl=ENSBTAG00000011494|UniProtKB=Q0VCM4	Glycogen phosphorylase, liver form	ISS	4318782	PubMed	PTHR11468:SF12	GLYCOGEN PHOSPHORYLASE, LIVER FORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANAL|CGD=CAL0003231|UniProtKB=Q5ANK2	Protein kinase C	ISS	8813761	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=69308|UniProtKB=Q63433	Serine/threonine-protein kinase N1	IC	10644715	PubMed	PTHR24356:SF246	SERINE/THREONINE-PROTEIN KINASE N1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000012778|UniProtKB=H2QJ75	Phosphoinositide phospholipase C	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02765	Phenylalanine biosynthesis	P03099	Prephenate dehydratase	ARATH|TAIR=AT5G22630|UniProtKB=Q9FNJ8	Arogenate dehydratase 5, chloroplastic	ISS			PTHR21022:SF14	AROGENATE DEHYDRATASE 3, CHLOROPLASTIC-RELATED
P00012	Cadherin signaling pathway	P00477	GSK3beta	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01095	beta	PANTR|Ensembl=ENSPTRG00000001389|UniProtKB=H2Q056	Uncharacterized protein	ISS	15155845	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	MOUSE|MGI=MGI=96435|UniProtKB=Q07113	Cation-independent mannose-6-phosphate receptor	ISS	11081635	PubMed	PTHR15071:SF17	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	MOUSE|MGI=MGI=2446584|UniProtKB=P58500	MAP3K7 C-terminal-like protein	ISS			PTHR26392:SF77	EXTRACELLULAR TYROSINE-PROTEIN KINASE PKDCC
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00029	Huntington disease	P00786	ARF	DANRE|ZFIN=ZDB-GENE-040122-4|UniProtKB=Q6NYD8	ADP-ribosylation factor 2	ISS	12932731	PubMed	PTHR11711:SF299	ADP-RIBOSYLATION FACTOR 2
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CAEBR|Gene=CBG03422|UniProtKB=A8WV10	Protein CBR-CWN-2	ISS	11266476	PubMed	PTHR12027:SF77	PROTEIN WNT-5
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00004	Alzheimer disease-presenilin pathway	P00141	Membrane metalloprotease	HUMAN|HGNC=7163|UniProtKB=Q9ULZ9	Matrix metalloproteinase-17	RCA			PTHR10201:SF21	MATRIX METALLOPROTEINASE-17
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00006	Apoptosis signaling pathway	P00260	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01080	AChE	HUMAN|HGNC=983|UniProtKB=P06276	Cholinesterase	IC			PTHR43918:SF5	CHOLINESTERASE
P00047	PDGF signaling pathway	P01154	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BRAFL|Gene=BRAFLDRAFT_113720|UniProtKB=C3YYJ8	Protein Wnt	TAS	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00005	Angiogenesis	P00200	Dsh	RAT|RGD=620632|UniProtKB=Q9WVB9	Segment polarity protein dishevelled homolog DVL-1	ISS	11212302	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P00018	EGF receptor signaling pathway	P00551	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00645	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01153	GSK3	DROME|FlyBase=FBgn0046332|UniProtKB=P83101	Putative glycogen synthase kinase-3 homolog	ISS	21361340	gi	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	MONDO|Ensembl=ENSMODG00000007323|UniProtKB=F7EFD0	Uncharacterized protein	ISS	1904317	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00559	MEK1-2	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IGI	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02787	Vitamin B6 metabolism	P03229	Pyridoxal reductase	SCHPO|PomBase=SPAC3A11.11c|UniProtKB=O14125	Uncharacterized oxidoreductase C3A11.11c	ISS	11859360	PubMed	PTHR43625:SF14	PYRIDOXAL REDUCTASE-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	HUMAN|HGNC=6270|UniProtKB=Q92806	G protein-activated inward rectifier potassium channel 3	ISS	12374786	PubMed	PTHR11767:SF17	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00025	Hedgehog signaling pathway	P00682	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	IDA	10477300	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000037429|UniProtKB=F1MGM3	Uncharacterized protein	ISS	11454663	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P00058	mRNA splicing	P01473	U6	SCHPO|PomBase=SPAC29E6.02|UniProtKB=Q09856	U4/U5/U6 small nuclear ribonucleoprotein prp3	ISS			PTHR14212:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3
P05730	Endogenous cannabinoid signaling	P05746	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00047	PDGF signaling pathway	P01143	ERK	RAT|RGD=621505|UniProtKB=P0C865	Mitogen-activated protein kinase 7	ISS	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	HUMAN|HGNC=9509|UniProtKB=P49810	Presenilin-2	IDA	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Ensembl=ENSCAFG00000013179|UniProtKB=E2RPU9	Uncharacterized protein	ISS	11259487	PubMed	PTHR24229:SF11	NOCICEPTIN RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MOUSE|MGI=MGI=1338824|UniProtKB=O54828	Regulator of G-protein signaling 9	IDA	9459445	PubMed	PTHR10845:SF170	REGULATOR OF G-PROTEIN SIGNALING 9
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	MACMU|Ensembl=ENSMMUG00000010508|UniProtKB=F7B8E3	Uncharacterized protein	ISS			PTHR11405:SF38	CARBAMOYL-PHOSPHATE SYNTHASE  AMMONIA , MITOCHONDRIAL
P00047	PDGF signaling pathway	P01170	PDGF	BOVIN|Ensembl=ENSBTAG00000021697|UniProtKB=B1H0W5	PDGFB protein	ISS			PTHR11633:SF2	PLATELET-DERIVED GROWTH FACTOR SUBUNIT B
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05915	Opioid proenkephalin pathway	P05994	G-protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000024162|UniProtKB=H2R198	Protocadherin 18	ISS	8120095	PubMed	PTHR24028:SF9	PROTOCADHERIN-18
P00004	Alzheimer disease-presenilin pathway	P00125	Ire-1 C-terminal fragment	ORYSJ|EnsemblGenome=OS07G0471000|UniProtKB=Q7XIT1	Os07g0471000 protein	IDA	10619423	PubMed	PTHR13954:SF6	INOSITOL-REQUIRING ENZYME-1
P00046	Oxidative stress response	P01129	JNK1/2	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04393	Ras Pathway	P04552	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00010	B cell activation	P00392	I kappa B	CHICK|Gene=NFKBIA|UniProtKB=Q91974	NF-kappa-B inhibitor alpha	IDA	10811867	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00010	B cell activation	P00376	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00053	T cell activation	P01304	Csk	MACMU|Ensembl=ENSMMUG00000015267|UniProtKB=F7GRP2	Tyrosine-protein kinase	ISS	7687537	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00018	EGF receptor signaling pathway	P00544	c-Cbl	RAT|RGD=1561386|UniProtKB=D3ZV15	Protein Cbl	ISS	4885117	gi	PTHR23007:SF5	E3 UBIQUITIN-PROTEIN LIGASE CBL
P04398	p53 pathway feedback loops 2	P04651	Ras	BOVIN|Ensembl=ENSBTAG00000009778|UniProtKB=E1BMX0	Uncharacterized protein	ISS	3023884	PubMed	PTHR24070:SF186	GTPASE KRAS
P00010	B cell activation	P00384	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MACMU|Ensembl=ENSMMUG00000015717|UniProtKB=F6SFA9	Serotonin receptor type 1B	ISS	12181435	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P00059	p53 pathway	P04623	CBP	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01175	Shc	ANOGA|EnsemblGenome=AGAP011463|UniProtKB=Q7Q334	AGAP011463-PA	ISS			PTHR10337:SF11	DSHC PROTEIN
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	CHICK|Ensembl=ENSGALG00000011442|UniProtKB=Q90999	TGF-beta receptor type-2	TAS	9395284	PubMed	PTHR23255:SF55	TGF-BETA RECEPTOR TYPE-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	XENTR|Xenbase=XB-GENE-5793509|UniProtKB=F6SXB7	Uncharacterized protein (Fragment)	ISS			PTHR18945:SF75	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-3
P00011	Blood coagulation	P00418	Fibrin monomer	HUMAN|HGNC=3694|UniProtKB=P02679	Fibrinogen gamma chain	ISS	80015086	PubMed	PTHR19143:SF338	FIBRINOGEN GAMMA CHAIN
P00053	T cell activation	P01316	MHC-antigen	MACMU|Ensembl=ENSMMUG00000009113|UniProtKB=F7E9S4	Uncharacterized protein	ISS	73139	PubMed	PTHR14093:SF17	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN GAMMA CHAIN
P00006	Apoptosis signaling pathway	P00304	XIAP	RAT|RGD=620692|UniProtKB=Q9R0I6	E3 ubiquitin-protein ligase XIAP	ISS			PTHR10044:SF115	BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 8-RELATED
P05915	Opioid proenkephalin pathway	P05994	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	HUMAN|HGNC=5960|UniProtKB=O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00029	Huntington disease	G01530	HTT	CANLF|Ensembl=ENSCAFG00000014682|UniProtKB=F1P7Y7	Uncharacterized protein	ISS	7620118	PubMed	PTHR10170:SF10	HUNTINGTIN
P00038	JAK/STAT signaling pathway	P01031	PIAS	MACMU|Ensembl=ENSMMUG00000011699|UniProtKB=F7HEF3	E3 SUMO-protein ligase PIAS1	ISS	8682149	PubMed	PTHR10782:SF11	E3 SUMO-PROTEIN LIGASE PIAS1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00009	Axon guidance mediated by netrin	P00364	cdc42	XENTR|Xenbase=XB-GENE-967585|UniProtKB=Q28BZ0	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P02783	Tryptophan biosynthesis	P03211	Phosphribosyl anthranilate isomerase	ARATH|TAIR=AT1G07780|UniProtKB=Q42440	N-(5'-phosphoribosyl)anthranilate isomerase 1, chloroplastic	ISS			PTHR42894:SF1	N- 5'-PHOSPHORIBOSYL ANTHRANILATE ISOMERASE
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	MOUSE|MGI=MGI=109482|UniProtKB=P97445	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	8386525	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00048	PI3 kinase pathway	P01177	P110ACT	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	IC	11256888	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P02724	Alanine biosynthesis	P02815	Branched chain amino acid aminotransferase	YEAST|SGD=S000001251|UniProtKB=P38891	Branched-chain-amino-acid aminotransferase, mitochondrial	ISS			PTHR11825:SF44	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04397	p53 pathway by glucose deprivation	P04644	TSC2	MOUSE|MGI=MGI=102548|UniProtKB=Q61037	Tuberin	IDA	12150915	PubMed	PTHR10063:SF0	TUBERIN
P02750	Lipoate_biosynthesis	P03004	Lipoate synthase	ARATH|TAIR=AT2G20860|UniProtKB=Q9ZWT1	Lipoyl synthase, mitochondrial	ISS			PTHR10949:SF25	LIPOYL SYNTHASE, MITOCHONDRIAL
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	ANOGA|EnsemblGenome=AGAP006479|UniProtKB=Q7Q5E6	AGAP006479-PA	IC			PTHR13140:SF725	DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C
P00059	p53 pathway	P04633	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02785	Valine biosynthesis	P03216	Acetolactate synthase	METJA|EnsemblGenome=MJ_0663|UniProtKB=Q58077	Uncharacterized protein MJ0663	ISS			PTHR18968:SF13	ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL
P00021	FGF signaling pathway	P00629	PP2A	HUMAN|HGNC=9299|UniProtKB=P67775	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P02775	Salvage pyrimidine ribonucleotides	P03149	Cytidine kinase	RAT|RGD=1308313|UniProtKB=B5DF24	Uridine-cytidine kinase	ISS			PTHR10285:SF66	URIDINE-CYTIDINE KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	MONDO|Ensembl=ENSMODG00000002696|UniProtKB=F7CY56	Uncharacterized protein	ISS			PTHR23050:SF335	CALMODULIN, STRIATED MUSCLE
P00021	FGF signaling pathway	P00627	ERK1-2	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00019	Endothelin signaling pathway	P00590	IP3 R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=1095414|UniProtKB=Q9R100	Cadherin-17	IDA	8120095	PubMed	PTHR44603:SF2	CADHERIN-17
P02746	Heme biosynthesis	P02981	Glutamate-1-semialdehyde aminotransferase	METAC|EnsemblGenome=MA_0581|UniProtKB=Q8TT57	Glutamate-1-semialdehyde 2,1-aminomutase	ISS			PTHR43713:SF3	GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE
P00059	p53 pathway	P04630	PP2A	XENTR|Xenbase=XB-GENE-957248|UniProtKB=Q6GLE6	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00398	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IGI	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	21150461	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05731	GABA-B receptor II signaling	P05755	Gbeta	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	DANRE|ZFIN=ZDB-GENE-040712-6|UniProtKB=Q6DRP4	Cerebral cavernous malformations protein 2 homolog	ISS			PTHR21642:SF4	CEREBRAL CAVERNOUS MALFORMATIONS 2 PROTEIN
P00057	Wnt signaling pathway	P01465	Ggamma	ORNAN|Ensembl=ENSOANG00000013961|UniProtKB=F6VPY1	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT4G01370|UniProtKB=Q39024	Mitogen-activated protein kinase 4	ISS	2191146	gi	PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00018	EGF receptor signaling pathway	P00558	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00513	Op18/stathmin	CHICK|Ensembl=ENSGALG00000001475|UniProtKB=P31395	Stathmin	ISS			PTHR10104:SF5	STATHMIN
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	HUMAN|HGNC=4587|UniProtKB=Q14957	Glutamate receptor ionotropic, NMDA 2C	ISS	11319238	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_115566|UniProtKB=C3XYC8	Putative uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00054	Toll receptor signaling pathway	P01368	MKK2	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	HUMAN|HGNC=2093|UniProtKB=P53675	Clathrin heavy chain 2	IDA	9388255	PubMed	PTHR10292:SF6	CLATHRIN HEAVY CHAIN 2
P00057	Wnt signaling pathway	P01451	Galpha	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2051|UniProtKB=P28647	Adenosine receptor A3	ISS	11781138	PubMed	PTHR24246:SF2	ADENOSINE RECEPTOR A3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04393	Ras Pathway	P04556	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	DANRE|ZFIN=ZDB-GENE-040426-1013|UniProtKB=Q6P0T2	Transcription initiation factor TFIID subunit 8	ISS	604904	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000000261|UniProtKB=F6X9C0	Adenosine receptor A2	ISS			PTHR24246:SF27	ADENOSINE RECEPTOR A2A
P00021	FGF signaling pathway	P00624	14-3-3	MACMU|Ensembl=ENSMMUG00000013206|UniProtKB=F6XFG9	14-3-3 protein beta/alpha	ISS	1671102	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00004	Alzheimer disease-presenilin pathway	P00144	Ire-1	BOVIN|Ensembl=ENSBTAG00000016799|UniProtKB=F1MM00	Uncharacterized protein	ISS	10619423	PubMed	PTHR13954:SF17	SERINE/THREONINE-PROTEIN KINASE/ENDORIBONUCLEASE IRE1
P02731	Biotin biosynthesis	P02858	8-Amino-7-oxononanoate synthase	STRCO|Gene=CAA16181|UniProtKB=O54153	Putative 8-amino-7-oxononanoate synthase	ISS			PTHR13693:SF77	8-AMINO-7-OXONONANOATE SYNTHASE
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	RAT|RGD=2743|UniProtKB=P31421	Metabotropic glutamate receptor 2	ISS	20012997	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00009	Axon guidance mediated by netrin	P00363	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MONDO|Ensembl=ENSMODG00000011628|UniProtKB=F6U132	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00057	Wnt signaling pathway	P01465	Ggamma	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00053	T cell activation	P01332	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00559	MEK1-2	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00047	PDGF signaling pathway	P01159	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00048	PI3 kinase pathway	P01192	p110	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	TAKRU|Ensembl=ENSTRUG00000014739|UniProtKB=H2UL58	Tyrosine-protein kinase	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IDA	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00004	Alzheimer disease-presenilin pathway	P00118	E-cadherin	RAT|RGD=69279|UniProtKB=Q9R0T4	Cadherin-1	IDA	11953314	PubMed	PTHR24027:SF319	CADHERIN-1
P04393	Ras Pathway	P04546	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	HUMAN|HGNC=1950|UniProtKB=P11229	Muscarinic acetylcholine receptor M1	ISS	12181435	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P04393	Ras Pathway	P04572	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00050	Plasminogen activating cascade	P01253	Fibrin	MOUSE|MGI=MGI=99501|UniProtKB=Q8K0E8	Fibrinogen beta chain	ISS	1706801	gi	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00021	FGF signaling pathway	P00627	ERK1-2	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00049	Parkinson disease	P01242	Casein kinase I	SCHPO|PomBase=SPBC3H7.15|UniProtKB=P40235	Casein kinase I homolog hhp1	IDA	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00057	Wnt signaling pathway	P01444	Wnt	XENTR|Xenbase=XB-GENE-484098|UniProtKB=F6ZQ88	Protein Wnt (Fragment)	ISS	8717036	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01438	PP2A	PANTR|Ensembl=ENSPTRG00000003853|UniProtKB=H2Q411	Protein phosphatase 2, regulatory subunit B', beta	ISS	96161994	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	STRCO|EnsemblGenome=CAA18341|UniProtKB=O69981	Vitamin B12-dependent ribonucleotide reductase	ISS			PTHR43371:SF1	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00590	IP3 R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IGI	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05913	Enkephalin release	P05972	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P06664	Gonadotropin-releasing hormone receptor pathway	P06843	EGFR	MOUSE|MGI=MGI=95294|UniProtKB=Q01279	Epidermal growth factor receptor	RCA	21100872	PubMed	PTHR24416:SF91	EPIDERMAL GROWTH FACTOR RECEPTOR
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	BOVIN|Ensembl=ENSBTAG00000000219|UniProtKB=F1MCL3	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	MOUSE|MGI=MGI=94927|UniProtKB=Q8BLD9	D(1B) dopamine receptor	ISS	11248120	PubMed	PTHR43893:SF8	D 1B  DOPAMINE RECEPTOR
P00045	Notch signaling pathway	P01109	Aph-1	PANTR|Ensembl=ENSPTRG00000007146|UniProtKB=H2Q9J9	Anterior pharynx defective 1 homolog B	ISS	12763021	PubMed	PTHR12889:SF1	GAMMA-SECRETASE SUBUNIT APH-1B
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	NEUCR|EnsemblGenome=EFNCRG00000002886|UniProtKB=Q1K904	MAP kinase kinase kinase SskB	ISS			PTHR24361:SF651	STE20-RELATED KINASE ADAPTER PROTEIN STRD-1
P00030	Hypoxia response via HIF activation	P00824	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	DANRE|ZFIN=ZDB-GENE-990415-229|UniProtKB=Q8QFM3	Frizzled 7a	TAS	8717036	PubMed	PTHR11309:SF31	FRIZZLED-7
P00006	Apoptosis signaling pathway	P00321	HSP70	CANLF|Ensembl=ENSCAFG00000000641|UniProtKB=G1K268	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF223	HEAT SHOCK 70 KDA PROTEIN 1A-RELATED
P00021	FGF signaling pathway	P00645	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	IPI	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IPI	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	IDA	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00047	PDGF signaling pathway	P01160	IP3 receptor	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	PANTR|Ensembl=ENSPTRG00000013825|UniProtKB=H2RAK4	Uncharacterized protein	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	RCA	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01094	gamma	HUMAN|HGNC=1967|UniProtKB=P07510	Acetylcholine receptor subunit gamma	ISS	95224005	PubMed	PTHR18945:SF60	ACETYLCHOLINE RECEPTOR SUBUNIT GAMMA
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=109356|UniProtKB=O09044	Synaptosomal-associated protein 23	IC	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04398	p53 pathway feedback loops 2	P04651	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	91232861	PubMed	PTHR24070:SF385	GTPASE HRAS
P00053	T cell activation	P01300	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04398	p53 pathway feedback loops 2	P04651	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	ANOGA|EnsemblGenome=AGAP006818|UniProtKB=Q7QIF4	AGAP006818-PA	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	RAT|RGD=621404|UniProtKB=Q62761	Casein kinase I isoform gamma-1	ISS	10617630	PubMed	PTHR11909:SF156	CASEIN KINASE I ISOFORM GAMMA-1
P00005	Angiogenesis	P00200	Dsh	MOUSE|MGI=MGI=106613|UniProtKB=Q60838	Segment polarity protein dishevelled homolog DVL-2	ISS	11212302	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P05916	Opioid prodynorphin pathway	P06002	G-protein	ORNAN|Ensembl=ENSOANG00000003489|UniProtKB=F7FSE3	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	P01440	Cadherin	CANLF|Ensembl=ENSCAFG00000020425|UniProtKB=F1P6U6	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF85	CADHERIN-11
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00053	T cell activation	P01319	PAK	MONDO|Ensembl=ENSMODG00000018459|UniProtKB=F7CU42	Uncharacterized protein	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	RAT|RGD=628595|UniProtKB=Q4QRB4	Tubulin beta-3 chain	ISS	9454836	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00021	FGF signaling pathway	P00623	FGF	MOUSE|MGI=MGI=109189|UniProtKB=P70379	Fibroblast growth factor 14	ISS	8790420	PubMed	PTHR11486:SF18	FIBROBLAST GROWTH FACTOR 14
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	DROME|FlyBase=FBgn0024179|UniProtKB=M9PE88	Receptor protein serine/threonine kinase	ISS	11856529	PubMed	PTHR23255:SF52	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	IC	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	MACMU|Ensembl=ENSMMUG00000022317|UniProtKB=F6XD59	Uncharacterized protein	ISS	10778855	PubMed	PTHR44172:SF1	COLLAGEN ALPHA-2 VI  CHAIN
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	PANTR|Ensembl=ENSPTRG00000013434|UniProtKB=H2QK91	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF138	MATRIX METALLOPROTEINASE-24
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	RAT|RGD=1586146|UniProtKB=G3V716	Protein Rgs20	ISS	8756726	PubMed	PTHR10845:SF175	REGULATOR OF G-PROTEIN SIGNALING 20
P00056	VEGF signaling pathway	P01415	MAPKAPK2/3	HUMAN|HGNC=6887|UniProtKB=P49137	MAP kinase-activated protein kinase 2	ISS	7923354	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00034	Integrin signalling pathway	P00948	Rho	XENTR|Xenbase=XB-GENE-478301|UniProtKB=Q6NVL3	Ras homolog gene family, member B	ISS	11973360	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00057	Wnt signaling pathway	P01451	Galpha	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	IDA	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00018	EGF receptor signaling pathway	P00558	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IDA	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02730	Asparagine and aspartate biosynthesis	P02853	Asparagine synthetase	ARATH|TAIR=AT5G10240|UniProtKB=Q9LFU1	Asparagine synthetase [glutamine-hydrolyzing] 3	ISS			PTHR11772:SF13	ASPARAGINE SYNTHETASE  GLUTAMINE-HYDROLYZING  2-RELATED
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05916	Opioid prodynorphin pathway	P05997	prodynorphin	HUMAN|HGNC=8820|UniProtKB=P01213	Proenkephalin-B	RCA	131330	OMIM	PTHR11438:SF4	PROENKEPHALIN-B
P00059	p53 pathway	P01480	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00060	Ubiquitin proteasome pathway	P01492	E1	RAT|RGD=1359327|UniProtKB=Q5U300	Ubiquitin-like modifier-activating enzyme 1	ISS			PTHR10953:SF155	UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 1
P00034	Integrin signalling pathway	P00927	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01438	PP2A	XENTR|Xenbase=XB-GENE-957526|UniProtKB=K9J7P6	Uncharacterized protein	ISS	11007767	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00046	Oxidative stress response	P01131	MKP5	PANTR|Ensembl=ENSPTRG00000012710|UniProtKB=H2QJ38	Uncharacterized protein	ISS			PTHR10159:SF402	DUAL SPECIFICITY PROTEIN PHOSPHATASE 19
P06959	CCKR signaling map	P07095	PKCalpha	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	RCA	7487955	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06779	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	RCA	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00799	JNK-2	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00010	B cell activation	P00384	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CHICK|Gene=CHRNA6|UniProtKB=P49581	Neuronal acetylcholine receptor subunit alpha-6	IC	85270494	PubMed	PTHR18945:SF82	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-6
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00011	Blood coagulation	P00454	FVII	MOUSE|MGI=MGI=109325|UniProtKB=P70375	Coagulation factor VII	ISS	2499859	gi	PTHR44064:SF1	COAGULATION FACTOR VII
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	BOVIN|Gene=MYH2|UniProtKB=Q9BE41	Myosin-2	IEP	10938134	PubMed	PTHR13140:SF385	MYOSIN-2
P00006	Apoptosis signaling pathway	P00269	MAPK	ORYSJ|EnsemblGenome=OS03G0285800|UniProtKB=Q10N20	Mitogen-activated protein kinase 5	ISS	9836510	gi	PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00586	Gq	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IGI	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00778	NMDA receptor	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	IDA	http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	TAKRU|Ensembl=ENSTRUG00000006307|UniProtKB=H2SSM1	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00018	EGF receptor signaling pathway	P00539	14-3-3	ARATH|TAIR=AT1G22290|UniProtKB=F4I1B7	14-3-3 family protein	ISS			PTHR18860:SF32	14-3-3 FAMILY PROTEIN-RELATED
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05915	Opioid proenkephalin pathway	P05994	G-protein	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00018	EGF receptor signaling pathway	P00565	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00054	Toll receptor signaling pathway	P01356	ERK2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00807	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g234494|UniProtKB=A7RU31	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00034	Integrin signalling pathway	P00927	Rac	ENTHI|EnsemblGenome=EHI_181250|UniProtKB=C4M5Z7	Rho family GTPase	IGI	97082968	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00048	PI3 kinase pathway	P01179	PKB	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00949	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	10982827	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P05731	GABA-B receptor II signaling	P05755	Gbeta	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00053	T cell activation	P01300	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06803	Rap1b	MOUSE|MGI=MGI=894315|UniProtKB=Q99JI6	Ras-related protein Rap-1b	RCA	8576107	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00007	Axon guidance mediated by semaphorins	P00336	Cdk5	TAKRU|Ensembl=ENSTRUG00000004034|UniProtKB=H2SAY8	Uncharacterized protein	ISS	12372285	PubMed	PTHR24056:SF46	CYCLIN-DEPENDENT-LIKE KINASE 5
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	ORNAN|Ensembl=ENSOANG00000000493|UniProtKB=F7EPA8	Uncharacterized protein	ISS	1608964	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00012	Cadherin signaling pathway	P00462	Casein kinase II	CAEEL|WormBase=WBGene00002191|UniProtKB=P18334	Casein kinase II subunit alpha	ISS	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	SYNY3|EnsemblGenome=BAA17330|UniProtKB=P73302	Adenylate kinase 1	ISS			PTHR23359:SF22	GTP:AMP PHOSPHOTRANSFERASE, MITOCHONDRIAL
P02722	Acetate utilization	P02801	Acetate kinase	GLOVI|EnsemblGenome=BAC88941|UniProtKB=Q7NLW9	Acetate kinase	ISS			PTHR21060:SF11	SUBFAMILY NOT NAMED
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00057	Wnt signaling pathway	P01453	Ebi	XENTR|Xenbase=XB-GENE-482046|UniProtKB=F6WUH3	Uncharacterized protein	ISS	11389839	PubMed	PTHR22846:SF40	F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN TBL1XR1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00009	Axon guidance mediated by netrin	P00366	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00577	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02777	Succinate to proprionate conversion	P03161	Methylmalonyl-CoA mutase	PANTR|Ensembl=ENSPTRG00000018256|UniProtKB=H2QT52	Methylmalonyl CoA mutase	ISS			PTHR42710:SF1	METHYLMALONYL-COA MUTASE, MITOCHONDRIAL
P00048	PI3 kinase pathway	P01181	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IPI	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00047	PDGF signaling pathway	P01157	MAPKAPK2	DROME|FlyBase=FBgn0013987|UniProtKB=P49071	MAP kinase-activated protein kinase 2	ISS			PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ANOGA|Gene=AgaP_AGAP010273|UniProtKB=Q7PMF0	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	RAT|RGD=2520|UniProtKB=P61169	D(2) dopamine receptor	ISS	11248120	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00018	EGF receptor signaling pathway	P00565	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00737	Rap1GAP	CANLF|Ensembl=ENSCAFG00000020142|UniProtKB=E2RR44	Uncharacterized protein	ISS	10419452	PubMed	PTHR15711:SF31	GTPASE-ACTIVATING RAP/RAN-GAP DOMAIN-LIKE PROTEIN 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00747	Rhodopsin	DANRE|ZFIN=ZDB-GENE-990415-271|UniProtKB=P35359	Rhodopsin	IDA	1634520	PubMed	PTHR24240:SF15	RHODOPSIN
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00034	Integrin signalling pathway	P00936	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	IPI	12660731	PubMed	PTHR10048:SF14	PI-3 KINASE
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000000985|UniProtKB=F6VRS9	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00047	PDGF signaling pathway	P01143	ERK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05915	Opioid proenkephalin pathway	P05994	G-protein	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00019	Endothelin signaling pathway	P00572	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IGI	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00021	FGF signaling pathway	P00639	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	8264585	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00034	Integrin signalling pathway	P00938	Cdc42	ANOGA|EnsemblGenome=AGAP002440|UniProtKB=Q17031	Cdc42 homolog	ISS	9658176	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00017	DNA replication	P00527	Histones	STRPU|EnsemblGenome=SPU_007835|UniProtKB=W4XWM4	Histone H3	ISS	12413958	PubMed	PTHR11426:SF20	HISTONE H3-LIKE CENTROMERIC PROTEIN A
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01448	CBP	MACMU|Ensembl=ENSMMUG00000000893|UniProtKB=F6T7D0	Histone acetyltransferase p300	ISS	8413673	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00004	Alzheimer disease-presenilin pathway	P00170	Aph-1	MOUSE|MGI=MGI=2385110|UniProtKB=Q8BVF7	Gamma-secretase subunit APH-1A	ISS	12110170	PubMed	PTHR12889:SF3	GAMMA-SECRETASE SUBUNIT APH-1A
P00057	Wnt signaling pathway	P01465	Ggamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00023	General transcription regulation	P00658	TBP-associated factors	DANRE|ZFIN=ZDB-GENE-040426-1013|UniProtKB=Q6P0T2	Transcription initiation factor TFIID subunit 8	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	MACMU|Ensembl=ENSMMUG00000021514|UniProtKB=F7FFT5	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF757	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-2
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g210933|UniProtKB=A7SEA7	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00018	EGF receptor signaling pathway	P00565	PKC	CANAL|CGD=CAL0003231|UniProtKB=Q5ANK2	Protein kinase C	IGI	125549	gi	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00005	Angiogenesis	P00238	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	RAT|RGD=628837|UniProtKB=P60711	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00048	PI3 kinase pathway	P01189	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PRIPA|Gene=PPA23459|UniProtKB=H3FMF2	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00048	PI3 kinase pathway	G01546	Cyclin d	CHICK|Ensembl=ENSGALG00000017283|UniProtKB=P49706	G1/S-specific cyclin-D2	ISS			PTHR10177:SF66	G1/S-SPECIFIC CYCLIN-D2
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00019	Endothelin signaling pathway	P00589	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	IC	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00019	Endothelin signaling pathway	P00587	Raf-1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IGI	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	RAT|RGD=621005|UniProtKB=Q08849	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	CAEBR|Gene=CBG02059|UniProtKB=A8WRW6	Protein CBR-UNC-2 (Fragment)	ISS	14507926	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P05916	Opioid prodynorphin pathway	G06047	preprodynorphin	HUMAN|HGNC=8820|UniProtKB=P01213	Proenkephalin-B	RCA	131330	OMIM	PTHR11438:SF4	PROENKEPHALIN-B
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DANRE|ZFIN=ZDB-GENE-040625-35|UniProtKB=Q6IQL9	Novel actin protein	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00046	Oxidative stress response	P01134	cPLA2	MACMU|Ensembl=ENSMMUG00000021423|UniProtKB=F7EEZ1	Phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00057	Wnt signaling pathway	P01435	SWI/SNF	HUMAN|HGNC=11100|UniProtKB=P51532	Transcription activator BRG1	IDA	11532957	PubMed	PTHR10799:SF76	TRANSCRIPTION ACTIVATOR BRG1
P00057	Wnt signaling pathway	P01435	SWI/SNF	MOUSE|MGI=MGI=1933621|UniProtKB=Q99JR8	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2	ISS	11532957	PubMed	PTHR13844:SF2	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D MEMBER 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MACMU|Ensembl=ENSMMUG00000009341|UniProtKB=F6UA54	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00038	JAK/STAT signaling pathway	P01027	STAT	DANRE|ZFIN=ZDB-GENE-030820-2|UniProtKB=Q68SP3	Signal transducer and activator of transcription	ISS			PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CANLF|Ensembl=ENSCAFG00000003197|UniProtKB=E2QXY7	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	PANTR|Ensembl=ENSPTRG00000004701|UniProtKB=H2Q5G9	Low density lipoprotein receptor-related protein 6	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00057	Wnt signaling pathway	P01435	SWI/SNF	BACSU|EnsemblGenome=BSU36280|UniProtKB=P94593	Uncharacterized ATP-dependent helicase YwqA	IDA	11532957	PubMed	PTHR10799:SF810	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	MACMU|Ensembl=ENSMMUG00000023365|UniProtKB=F6VCD6	Uncharacterized protein	ISS	9783586	PubMed	PTHR10814:SF21	TRANSDUCIN-LIKE ENHANCER PROTEIN 4
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CANLF|Ensembl=ENSCAFG00000013148|UniProtKB=Q5R1P3	Glutamate receptor ionotropic, NMDA 2B	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MACMU|Ensembl=ENSMMUG00000022937|UniProtKB=F6U717	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P00006	Apoptosis signaling pathway	P00314	MKK3	HUMAN|HGNC=6843|UniProtKB=P46734	Dual specificity mitogen-activated protein kinase kinase 3	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00018	EGF receptor signaling pathway	P00557	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00539	14-3-3	NEUCR|EnsemblGenome=EFNCRG00000002359|UniProtKB=Q7RVK6	14-3-3 family protein 7	ISS	22057342	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00029	Huntington disease	P00807	Actin	MACMU|Ensembl=ENSMMUG00000007027|UniProtKB=F7F210	Alpha-cardiac actin	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00054	Toll receptor signaling pathway	G01550	Gene trancription	RAT|RGD=620349|UniProtKB=P35355	Prostaglandin G/H synthase 2	ISS	12163371	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P00029	Huntington disease	P00786	ARF	BRAFL|Gene=BRAFLDRAFT_263946|UniProtKB=C3Z3B1	Putative uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF304	ADP-RIBOSYLATION FACTOR 1
P00005	Angiogenesis	P00189	Fzd	DROME|FlyBase=FBgn0027343|UniProtKB=O77438	Frizzled-3	ISS	11212302	PubMed	PTHR11309:SF125	FRIZZLED-3
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CAEBR|Gene=CBG18112|UniProtKB=A8XT20	Protein CBR-GLR-1	ISS	8804111	PubMed	PTHR18966:SF297	GLUTAMATE RECEPTOR 1
P00057	Wnt signaling pathway	P01428	Frizzled	XENTR|Xenbase=XB-GENE-480800|UniProtKB=F6VM33	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF90	FRIZZLED-8
P00060	Ubiquitin proteasome pathway	P01492	E1	CAEEL|WormBase=WBGene00006699|UniProtKB=Q27481	UBA (Human ubiquitin) related	ISS			PTHR10953:SF4	GH24511P
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1693|UniProtKB=Q6P967	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00010	B cell activation	P00398	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P05915	Opioid proenkephalin pathway	P05995	proenkephalin	HUMAN|HGNC=8831|UniProtKB=P01210	Proenkephalin-A	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00015	Circadian clock system	P00505	Cry	BOVIN|Ensembl=ENSBTAG00000021223|UniProtKB=F1N0J9	Uncharacterized protein	ISS	14507900	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00029	Huntington disease	P00776	c-Jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	12972619	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00006	Apoptosis signaling pathway	P00271	Bax	BOVIN|Ensembl=ENSBTAG00000013340|UniProtKB=O02703	Apoptosis regulator BAX	ISS	14963330	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MONDO|Ensembl=ENSMODG00000023429|UniProtKB=F6XI83	Uncharacterized protein	ISS	12181435	PubMed	PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P04393	Ras Pathway	P04550	Ral	MONDO|Ensembl=ENSMODG00000000264|UniProtKB=F6WB97	Uncharacterized protein	ISS	11025226	PubMed	PTHR24070:SF199	RAS-RELATED PROTEIN RAL-B
P00047	PDGF signaling pathway	P01171	PLCgamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00020	FAS signaling pathway	P00598	Pro-Caspase10	PANTR|Ensembl=ENSPTRG00000012800|UniProtKB=H2R694	Uncharacterized protein	ISS	8755496	PubMed	PTHR10454:SF26	CASPASE-10
P00021	FGF signaling pathway	P00648	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P02770	Pyridoxal phosphate salvage pathway	P03123	Pyridoxine-5-phosphate oxidase	PANTR|Ensembl=ENSPTRG00000009343|UniProtKB=H2QDB2	Pyridoxamine 5'-phosphate oxidase	ISS	14697241	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00005	Angiogenesis	P00187	beta catenin	HUMAN|HGNC=2514|UniProtKB=P35222	Catenin beta-1	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	3755548	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	8170357	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CANLF|Ensembl=ENSCAFG00000004930|UniProtKB=E2RFB5	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04393	Ras Pathway	P04556	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IDA	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02726	Aminobutyrate degradation	P02824	Succinate semi-aldehyde dehydrogenase	BACSU|EnsemblGenome=BSU03910|UniProtKB=P94428	Succinate-semialdehyde dehydrogenase [NADP(+)]	ISS	12891648	PubMed	PTHR43353:SF5	SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00036	Interleukin signaling pathway	P00970	Interleukin	CANLF|Gene=IL1A|UniProtKB=O46612	Interleukin-1 alpha	IDA	10452947	PubMed	PTHR45409:SF1	INTERLEUKIN-1 ALPHA
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=88399|UniProtKB=P32211	Muscarinic acetylcholine receptor M4	IDA	10069496	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	MACMU|Ensembl=ENSMMUG00000017143|UniProtKB=F7H113	Uncharacterized protein	ISS	11907044	PubMed	PTHR44025:SF5	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01098	CHT1	MOUSE|MGI=MGI=1927126|UniProtKB=Q8BGY9	High affinity choline transporter 1	RCA			PTHR11819:SF129	HIGH AFFINITY CHOLINE TRANSPORTER 1
P00030	Hypoxia response via HIF activation	P00817	TOR	BOVIN|Ensembl=ENSBTAG00000015325|UniProtKB=E1BFB4	Uncharacterized protein	ISS	14526383	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P05912	Dopamine receptor mediated signaling pathway	P05963	MAO	BOVIN|Gene=MAOB|UniProtKB=P56560	Amine oxidase [flavin-containing] B	ISS	8602220	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	ISS	12488551	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P02777	Succinate to proprionate conversion	P03161	Methylmalonyl-CoA mutase	STRCO|Gene=CAB70645|UniProtKB=Q7AKG5	Isobutyryl-CoA mutase A	ISS			PTHR43589:SF3	SUBFAMILY NOT NAMED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	TAS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00049	Parkinson disease	P01236	Casein kinase II	CAEBR|Gene=CBG12820|UniProtKB=A8XFP5	Protein CBR-KIN-3	ISS	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00220	c-Jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00036	Interleukin signaling pathway	P00976	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	HUMAN|HGNC=289|UniProtKB=P25098	Beta-adrenergic receptor kinase 1	IDA	8288567	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ORYSJ|EnsemblGenome=OS12G0163700|UniProtKB=Q0IPW3	Os12g0163700 protein	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P05734	Synaptic vesicle trafficking	P05780	Rab3A	MONDO|Ensembl=ENSMODG00000003214|UniProtKB=F6TZ81	Uncharacterized protein	ISS			PTHR24073:SF532	RAS-RELATED PROTEIN RAB-3A
P05918	p38 MAPK pathway	P06025	SRF	HUMAN|HGNC=11291|UniProtKB=P11831	Serum response factor	RCA	15326221	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	IDA	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00054	Toll receptor signaling pathway	P01358	ERK1	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P06664	Gonadotropin-releasing hormone receptor pathway	P06794	MAP2K1/2	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	RCA	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MOUSE|MGI=MGI=102705|UniProtKB=P63213	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IDA	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00048	PI3 kinase pathway	P01188	Gbetagamma	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00055	Transcription regulation by bZIP transcription factor	P01398	TFIIEalpha	HUMAN|HGNC=4650|UniProtKB=P29083	General transcription factor IIE subunit 1	IGI	189964	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00037	Ionotropic glutamate receptor pathway	P01026	KA	RAT|RGD=2734|UniProtKB=Q01812	Glutamate receptor ionotropic, kainate 4	ISS	1648176	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IDA	2837282	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00056	VEGF signaling pathway	P01415	MAPKAPK2/3	CAEEL|WormBase=WBGene00007007|UniProtKB=Q965G5	MAP kinase Activated protein Kinase	ISS			PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	TAKRU|Ensembl=ENSTRUG00000014690|UniProtKB=H2UKR9	Uncharacterized protein	IDA	2137198	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00006	Apoptosis signaling pathway	P00291	MEKK1	PANTR|Ensembl=ENSPTRG00000016891|UniProtKB=H2R5K3	Uncharacterized protein	ISS	12168099	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00001	Adrenaline and noradrenaline biosynthesis	P00061	PNMT	CAEEL|WormBase=WBGene00015124|UniProtKB=P34254	Nicotinamide N-methyltransferase	ISS			PTHR10867:SF17	NICOTINAMIDE N-METHYLTRANSFERASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000006307|UniProtKB=H2SSM1	Uncharacterized protein	ISS			PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	HUMAN|HGNC=2451|UniProtKB=P48729	Casein kinase I isoform alpha	IDA	11437445	PubMed	PTHR11909:SF84	CASEIN KINASE I ISOFORM ALPHA
P00005	Angiogenesis	P00219	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00057	Wnt signaling pathway	P01443	Phospholipase C	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IDA	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IC	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P02727	Androgen/estrogene/progesterone biosynthesis	P02829	Cholesterol acyltransferase	MACMU|Ensembl=ENSMMUG00000003768|UniProtKB=F7GXC5	O-acyltransferase	ISS	7592824	PubMed	PTHR10408:SF6	STEROL O-ACYLTRANSFERASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	ENTHI|EnsemblGenome=EHI_197840|UniProtKB=C4M8K6	Rho family GTPase	ISS	12932731	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00036	Interleukin signaling pathway	P00965	ERK	MACMU|Ensembl=ENSMMUG00000008536|UniProtKB=F6WBZ5	Mitogen-activated protein kinase	ISS	15085193	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00018	EGF receptor signaling pathway	P00541	Spry	PANTR|Ensembl=ENSPTRG00000005951|UniProtKB=H2Q7P2	Sprouty homolog 2	ISS	12402043	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00018	EGF receptor signaling pathway	G01511	SPRY	RAT|RGD=1305324|UniProtKB=D3ZJA3	Protein Spry4	ISS	99264295	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P00034	Integrin signalling pathway	P00906	Rap1	DICDI|dictyBase=DDB_G0291237|UniProtKB=P18613	Ras-related protein rapA	IPI	8576107	PubMed	PTHR24070:SF263	RAS-LIKE PROTEIN 3
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00005	Angiogenesis	P00182	p38MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00790	beta-Tubulin	PUCGT|EnsemblGenome=PGTG_12204|UniProtKB=E3KPL3	Tubulin beta chain	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00007	Axon guidance mediated by semaphorins	P00330	CRAM	RAT|RGD=620467|UniProtKB=Q9JHU0	Dihydropyrimidinase-related protein 5	ISS	10851247	PubMed	PTHR11647:SF58	DIHYDROPYRIMIDINASE-RELATED PROTEIN 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	PANTR|Ensembl=ENSPTRG00000008601|UniProtKB=H2QBY1	Arrestin, beta 2	ISS	12464600	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00021	FGF signaling pathway	P00623	FGF	PANTR|Ensembl=ENSPTRG00000005698|UniProtKB=H2Q7A1	Fibroblast growth factor	ISS			PTHR11486:SF28	FIBROBLAST GROWTH FACTOR 9
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00796	Kainate receptor	MOUSE|MGI=MGI=95815|UniProtKB=P39087	Glutamate receptor ionotropic, kainate 2	IDA	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	RCA	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00049	Parkinson disease	P01238	14-3-3	MONDO|Ensembl=ENSMODG00000009856|UniProtKB=F6WA79	Uncharacterized protein	ISS	12480176	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	STRPU|EnsemblGenome=SPU_005033|UniProtKB=W4XNQ0	Uncharacterized protein	ISS			PTHR23050:SF263	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT1G59580|UniProtKB=Q39022	Mitogen-activated protein kinase 2	ISS	15218451	gi	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00047	PDGF signaling pathway	P01153	GSK3	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Ensembl=ENSBTAG00000037726|UniProtKB=P10895	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	12860966	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008018|UniProtKB=F7EPG4	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00053	T cell activation	P01324	rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P02738	De novo purine biosynthesis	P02897	GTP reductase	FUSNN|EnsemblGenome=FN0311|UniProtKB=Q8RGI2	Anaerobic ribonucleoside-triphosphate reductase	ISS			PTHR21075:SF0	ANAEROBIC RIBONUCLEOSIDE-TRIPHOSPHATE REDUCTASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MONDO|Ensembl=ENSMODG00000004799|UniProtKB=F6VM87	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00029	Huntington disease	P00778	NMDA receptor	CAEBR|Gene=CBG02401|UniProtKB=A8WUE7	Protein CBR-NMR-1	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P02738	De novo purine biosynthesis	P02907	dADP kinase	MOUSE|MGI=MGI=1922783|UniProtKB=Q99MH5	Nucleoside diphosphate kinase homolog 5	ISS			PTHR11349:SF64	NUCLEOSIDE DIPHOSPHATE KINASE HOMOLOG 5
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	TAS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04393	Ras Pathway	P04558	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00563	Gab	PANTR|Ensembl=ENSPTRG00000004115|UniProtKB=H2R3E1	GRB2-associated binding protein 2	ISS	15356145	PubMed	PTHR12156:SF4	GRB2-ASSOCIATED-BINDING PROTEIN 2
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	ARATH|TAIR=AT5G58690|UniProtKB=Q944C2	Phosphoinositide phospholipase C 5	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00060	Ubiquitin proteasome pathway	P01491	E2	DANRE|ZFIN=ZDB-GENE-040426-2873|UniProtKB=Q803J2	Ube2n protein	ISS			PTHR43902:SF2	UBIQUITIN-CONJUGATING ENZYME E2 N
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	RAT|RGD=2521|UniProtKB=P19020	D(3) dopamine receptor	RCA	2039532	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00010	B cell activation	P00380	fos	CANLF|Ensembl=ENSCAFG00000017040|UniProtKB=E2QYK5	Uncharacterized protein	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MOUSE|MGI=MGI=1196625|UniProtKB=O70421	Frizzled-1	TAS	12549854	PubMed	PTHR11309:SF81	FRIZZLED-1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05913	Enkephalin release	G06046	preproenkephalin mRNA	XENTR|Xenbase=XB-GENE-942760|UniProtKB=F6Y5F6	Uncharacterized protein	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	HUMAN|HGNC=9509|UniProtKB=P49810	Presenilin-2	TAS	12846562	PubMed	PTHR10202:SF13	PRESENILIN-2
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=14550|UniProtKB=Q96JP9	Cadherin-related family member 1	IDA	8120095	PubMed	PTHR44506:SF1	CADHERIN-RELATED FAMILY MEMBER 1
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	MOUSE|MGI=MGI=109323|UniProtKB=Q02152	5-hydroxytryptamine receptor 2B	ISS	12181435	PubMed	PTHR24247:SF31	5-HYDROXYTRYPTAMINE RECEPTOR 2B
P00018	EGF receptor signaling pathway	P00562	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	HUMAN|HGNC=7572|UniProtKB=Q9UKX2	Myosin-2	ISS	89264452	PubMed	PTHR13140:SF385	MYOSIN-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00896	Insulin IGF	DANRE|ZFIN=ZDB-GENE-991111-3|UniProtKB=Q5U3B4	Insulin-like growth factor 2a	ISS	4504609	gi	PTHR11454:SF10	INSULIN-LIKE GROWTH FACTOR II
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	BOVIN|Ensembl=ENSBTAG00000006159|UniProtKB=E1BNE9	G protein-activated inward rectifier potassium channel 1	ISS	12374786	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00047	PDGF signaling pathway	P01154	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	SCLS1|EnsemblGenome=SS1G_05445|UniProtKB=A7EJF2	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	CHICK|Ensembl=ENSGALG00000008339|UniProtKB=E1BQS9	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P05731	GABA-B receptor II signaling	P05754	Ggamma	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00006	Apoptosis signaling pathway	P00313	IKK	CANLF|Ensembl=ENSCAFG00000005526|UniProtKB=E2RKR0	Uncharacterized protein	ISS	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	HUMAN|HGNC=1402|UniProtKB=Q08289	Voltage-dependent L-type calcium channel subunit beta-2	IC	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00780	Microtubule	MACMU|Ensembl=ENSMMUG00000012546|UniProtKB=F7E840	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00034	Integrin signalling pathway	P00923	Arf1	TAKRU|Ensembl=ENSTRUG00000014335|UniProtKB=H2UI79	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF294	ADP-RIBOSYLATION FACTOR 3
P00034	Integrin signalling pathway	P00944	Actin	DICDI|dictyBase=DDB_G0275023|UniProtKB=Q553U6	Putative actin-22	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00017	DNA replication	P00534	PCNA	PLAF7|EnsemblGenome=PFL1285c|UniProtKB=Q7KQJ9	Proliferating cell nuclear antigen	ISS	22352100	PubMed	PTHR11352:SF0	PROLIFERATING CELL NUCLEAR ANTIGEN
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	IC	11956331	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04572	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	HUMAN|HGNC=6697|UniProtKB=O75197	Low-density lipoprotein receptor-related protein 5	IDA	11029006	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P06587	Nicotine pharmacodynamics pathway	P06613	CHRNB2	MONDO|Ensembl=ENSMODG00000017165|UniProtKB=F6QDH4	Uncharacterized protein	ISS	15155845	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	XENTR|Xenbase=XB-GENE-941426|UniProtKB=Q28HZ4	Novel Rho protein	ISS	10556059	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P04398	p53 pathway feedback loops 2	P04665	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00780	Microtubule	HUMAN|HGNC=20774|UniProtKB=P04350	Tubulin beta-4A chain	IDA	12932731	PubMed	PTHR11588:SF253	TUBULIN BETA-4A CHAIN
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DROME|FlyBase=FBgn0261854|UniProtKB=A1Z9X0	Atypical protein kinase C	ISS	2837282	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00004	Alzheimer disease-presenilin pathway	P00163	Erb-B4 C-terminal fragment	CHICK|Ensembl=ENSGALG00000003126|UniProtKB=F1P258	Receptor protein-tyrosine kinase	ISS	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00021	FGF signaling pathway	P00633	Ras	DICPU|Gene=DICPUDRAFT_47179|UniProtKB=F0ZI47	Putative uncharacterized protein rasB	ISS	93205383	PubMed	PTHR24070:SF206	RAS-LIKE PROTEIN RASB
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	IDA	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	DANRE|ZFIN=ZDB-GENE-051202-2|UniProtKB=Q6ZM67	Uncharacterized protein	ISS	11554554	PubMed	PTHR44391:SF3	SUBFAMILY NOT NAMED
P00010	B cell activation	P00371	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00552	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	87226391	PubMed	PTHR24070:SF385	GTPASE HRAS
P04393	Ras Pathway	P04572	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=19663|UniProtKB=Q9UBI6	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00029	Huntington disease	P00775	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00010	B cell activation	P00376	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P06664	Gonadotropin-releasing hormone receptor pathway	G06677	Junc	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	RCA	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00053	T cell activation	P01307	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00053	T cell activation	P01306	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00008	Axon guidance mediated by Slit/Robo	P00355	Rho	MOUSE|MGI=MGI=106028|UniProtKB=Q62159	Rho-related GTP-binding protein RhoC	ISS	12090470	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P02772	Pyruvate metabolism	P03139	Lactate Dehydrogenase	TRIVA|Gene=TVAG_171100|UniProtKB=A2FIP9	L-lactate dehydrogenase, putative	IDA	10339579	PubMed	PTHR23382:SF0	MALATE DEHYDROGENASE 2, MITOCHONDRIAL-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=94925|UniProtKB=P30728	D(3) dopamine receptor	IDA	11248120	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P05734	Synaptic vesicle trafficking	P05770	Munc18	HUMAN|HGNC=11444|UniProtKB=P61764	Syntaxin-binding protein 1	TAS	8108429	PubMed	PTHR11679:SF35	SYNTAXIN-BINDING PROTEIN 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	P01483	Mdm2	PANTR|Ensembl=ENSPTRG00000005203|UniProtKB=H2R792	Mdm2 p53 binding protein homolog	ISS	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00055	Transcription regulation by bZIP transcription factor	P01390	TFIIA complex	MACMU|Ensembl=ENSMMUG00000030838|UniProtKB=F7FZJ9	Uncharacterized protein	ISS			PTHR12694:SF9	PROTEIN STON1-GTF2A1L-RELATED
P04393	Ras Pathway	P04567	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000000289|UniProtKB=F7A9T0	Uncharacterized protein	ISS	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00034	Integrin signalling pathway	P00941	Integrin alpha	MOUSE|MGI=MGI=1298377|UniProtKB=Q60677	Integrin alpha-E	IPI	3487386	PubMed	PTHR23220:SF79	INTEGRIN ALPHA-E
P04393	Ras Pathway	P04541	p90RSK	MACMU|Ensembl=ENSMMUG00000002134|UniProtKB=F6UNV6	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00029	Huntington disease	P00775	Rac	DICDI|dictyBase=DDB_G0286555|UniProtKB=P34147	Rho-related protein racA	TAS			PTHR24072:SF183	RHO-RELATED PROTEIN RACA
P05915	Opioid proenkephalin pathway	P05993	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P05731	GABA-B receptor II signaling	P05760	AC	MOUSE|MGI=MGI=87917|UniProtKB=Q01341	Adenylate cyclase type 6	RCA	2491850	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=107451|UniProtKB=Q8K2J0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3	ISS	15611108	PubMed	PTHR10336:SF33	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-3
P00034	Integrin signalling pathway	P00924	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IPI	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04413	K+ channel	MONDO|Ensembl=ENSMODG00000015769|UniProtKB=F6ZSC2	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	IDA	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00037	Ionotropic glutamate receptor pathway	P01018	Glu1	MACMU|Ensembl=ENSMMUG00000009287|UniProtKB=F7H3T9	Glutamate receptor 1 isoform 1	ISS	12871085	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00029	Huntington disease	P00805	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01179	PKB	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	12655147	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01368	MKK2	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00025	Hedgehog signaling pathway	P00682	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	176910	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01199	Galpha	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00050	Plasminogen activating cascade	P01245	PAI-1	RAT|RGD=3249|UniProtKB=P20961	Plasminogen activator inhibitor 1	ISS	6981332	gi	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00005	Angiogenesis	P00193	SOS-1	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00010	B cell activation	P00397	IKK	MACMU|Ensembl=ENSMMUG00000018476|UniProtKB=F6X938	Uncharacterized protein	ISS	12813046	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00021	FGF signaling pathway	P00627	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	8946911	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04397	p53 pathway by glucose deprivation	P04644	TSC2	RAT|RGD=3908|UniProtKB=P49816	Tuberin	IDA	12150915	PubMed	PTHR10063:SF0	TUBERIN
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	ORNAN|Ensembl=ENSOANG00000010302|UniProtKB=F6TDQ6	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DANRE|ZFIN=ZDB-GENE-040426-2894|UniProtKB=Q7SXW6	Actin-related protein 2-A	ISS	10974003	PubMed	PTHR11937:SF149	ACTIN-RELATED PROTEIN 2-A-RELATED
P00060	Ubiquitin proteasome pathway	P01491	E2	CANLF|Ensembl=ENSCAFG00000029379|UniProtKB=J9PAH6	Uncharacterized protein	ISS			PTHR44066:SF1	UBIQUITIN-CONJUGATING ENZYME E2 S
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01457	GBeta	ANOGA|EnsemblGenome=AGAP005912|UniProtKB=Q7Q6D3	AGAP005912-PA	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00021	FGF signaling pathway	P00644	p38	DROME|FlyBase=FBgn0015765|UniProtKB=O62618	Mitogen-activated protein kinase 14A	IGI	11707292	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04393	Ras Pathway	P04546	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00029	Huntington disease	P00807	Actin	SCLS1|Gene=SS1G_08733|UniProtKB=A7ETS6	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	ORNAN|Ensembl=ENSOANG00000001804|UniProtKB=F7CYD2	10-formyltetrahydrofolate dehydrogenase	ISS			PTHR11699:SF131	MITOCHONDRIAL 10-FORMYLTETRAHYDROFOLATE DEHYDROGENASE
P00048	PI3 kinase pathway	P01179	PKB	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MOUSE|MGI=MGI=87912|UniProtKB=P27040	Activin receptor type-2B	TAS	9395284	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	IC	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BOVIN|Ensembl=ENSBTAG00000005714|UniProtKB=Q3ZC07	Actin, alpha cardiac muscle 1	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	BOVIN|Ensembl=ENSBTAG00000002580|UniProtKB=F1MM57	Uncharacterized protein	ISS			PTHR13140:SF462	MYOSIN-14
P00029	Huntington disease	P00778	NMDA receptor	HUMAN|HGNC=4588|UniProtKB=O15399	Glutamate receptor ionotropic, NMDA 2D	IDA	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	RCA	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	3045562	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00005	Angiogenesis	P00212	EphR	CHICK|Gene=EPHB2|UniProtKB=P28693	Ephrin type-B receptor 2	ISS	9990854	PubMed	PTHR24416:SF123	EPHRIN TYPE-B RECEPTOR 2
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	176892	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	CHICK|Gene_ORFName=RCJMB04_17e23|UniProtKB=Q5ZJL5	Adenylosuccinate synthetase isozyme 2	ISS			PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DANRE|ZFIN=ZDB-GENE-040625-35|UniProtKB=Q6IQL9	Novel actin protein	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00009	Axon guidance mediated by netrin	P00364	cdc42	DANRE|ZFIN=ZDB-GENE-030131-8783|UniProtKB=Q52WY2	Ras-like protein Cdc42a	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00029	Huntington disease	P00805	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	G01581	BAX	HUMAN|HGNC=959|UniProtKB=Q07812	Apoptosis regulator BAX	ISS	8358790	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P00010	B cell activation	P00391	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	RCA	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00057	Wnt signaling pathway	P01465	Ggamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	SCHMA|EnsemblGenome=Smp_161920|UniProtKB=G4VSW5	Putative actin	ISS	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	RAT|RGD=621516|UniProtKB=G3V6P8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05915	Opioid proenkephalin pathway	P05991	Enkephalin	BOVIN|Gene=PDYN|UniProtKB=Q95104	Proenkephalin-B	ISS	131330	OMIM	PTHR11438:SF4	PROENKEPHALIN-B
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	EMENI|EnsemblGenome=CADANIAG00006296|UniProtKB=Q5ASG1	Putative synaptobrevin homologue SNC1/2 (Eurofung)	ISS			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00010	B cell activation	P00391	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01174	Rho	HUMAN|HGNC=676|UniProtKB=O43182	Rho GTPase-activating protein 6	ISS			PTHR12635:SF6	RHO GTPASE-ACTIVATING PROTEIN 6
P00019	Endothelin signaling pathway	P00585	ECE1-3	MOUSE|MGI=MGI=1101357|UniProtKB=Q4PZA2	Endothelin-converting enzyme 1	ISS	8034569	PubMed	PTHR11733:SF130	ENDOTHELIN-CONVERTING ENZYME 1
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05941	GRK3	PANTR|Ensembl=ENSPTRG00000014187|UniProtKB=H2R714	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00034	Integrin signalling pathway	P00922	Collagen	MACMU|Ensembl=ENSMMUG00000015325|UniProtKB=F6XE77	Uncharacterized protein	ISS	10778855	PubMed	PTHR44606:SF1	COLLAGEN ALPHA-1 XVII  CHAIN
P00021	FGF signaling pathway	P00628	JNK1-3	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IGI	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00006	Apoptosis signaling pathway	P00313	IKK	CANLF|Ensembl=ENSCAFG00000009588|UniProtKB=E2RNA9	Uncharacterized protein	ISS	12235208	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P04393	Ras Pathway	P04570	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00034	Integrin signalling pathway	P00936	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	IC	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00048	PI3 kinase pathway	P01177	P110ACT	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00635	FRS2	BOVIN|Ensembl=ENSBTAG00000019155|UniProtKB=E1B7I9	Uncharacterized protein	ISS	10464310	PubMed	PTHR21258:SF40	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00948	Rho	MACMU|Ensembl=ENSMMUG00000029963|UniProtKB=F6PQK0	Rho-related GTP-binding protein RhoN	ISS	11973360	PubMed	PTHR24072:SF21	RHO-RELATED GTP-BINDING PROTEIN RHON
P00053	T cell activation	P01294	NFAT	CANLF|Ensembl=ENSCAFG00000011625|UniProtKB=F1PDD9	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00034	Integrin signalling pathway	P00913	Csk	CHICK|Gene=CSK|UniProtKB=P41239	Tyrosine-protein kinase CSK	IDA	12665526	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P05913	Enkephalin release	P05972	PKA	LEIMA|EnsemblGenome=LmjF.18.1080|UniProtKB=Q27687	Protein kinase A catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00005	Angiogenesis	P00238	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IDA	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	9094314	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00057	Wnt signaling pathway	P01435	SWI/SNF	MONDO|Ensembl=ENSMODG00000006287|UniProtKB=F7CAF6	Uncharacterized protein	ISS	11532957	PubMed	PTHR10799:SF76	TRANSCRIPTION ACTIVATOR BRG1
P00019	Endothelin signaling pathway	P00577	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IGI	12660731	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00023	General transcription regulation	P00660	RNA Polymerase II	RAT|RGD=1589817|UniProtKB=B0BNE2	DNA-directed RNA polymerases I, II, and III subunit RPABC1	ISS			PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P02772	Pyruvate metabolism	P03132	Pyruvate Kinase	ARATH|TAIR=AT3G55810|UniProtKB=Q9M044	Pyruvate kinase	TAS	15228164	gi	PTHR11817:SF34	PYRUVATE KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IC	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00014	Cholesterol biosynthesis	P00498	Hydroxymethyl glutaryl CoA synthase	MOUSE|MGI=MGI=107592|UniProtKB=Q8JZK9	Hydroxymethylglutaryl-CoA synthase, cytoplasmic	ISS	600234	OMIM	PTHR43323:SF4	HYDROXYMETHYLGLUTARYL-COA SYNTHASE, CYTOPLASMIC
P04393	Ras Pathway	P04567	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=31104|UniProtKB=Q92614	Unconventional myosin-XVIIIa	IC			PTHR13140:SF421	UNCONVENTIONAL MYOSIN-XVIIIA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	HUMAN|HGNC=10437|UniProtKB=Q9UBS0	Ribosomal protein S6 kinase beta-2	ISS	6755374	gi	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=8154|UniProtKB=P41145	Kappa-type opioid receptor	IDA	11259498	PubMed	PTHR24229:SF1	KAPPA-TYPE OPIOID RECEPTOR
P02781	Threonine biosynthesis	P03191	Homoserine kinase	YEAST|SGD=S000001067|UniProtKB=P17423	Homoserine kinase	ISS			PTHR20861:SF1	HOMOSERINE KINASE
P00018	EGF receptor signaling pathway	P00546	GAP	BOVIN|Ensembl=ENSBTAG00000011829|UniProtKB=F1MHW1	Uncharacterized protein	ISS	18587532	gi	PTHR10194:SF60	NEUROFIBROMIN
P05730	Endogenous cannabinoid signaling	P05746	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04393	Ras Pathway	P04546	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IDA	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	LEIMA|EnsemblGenome=LmjF.23.0540|UniProtKB=Q4QBC0	Acetyl-coenzyme A synthetase	ISS			PTHR24095:SF14	ACETYL-COENZYME A SYNTHETASE 1
P00029	Huntington disease	P00790	beta-Tubulin	ARATH|TAIR=AT4G20890|UniProtKB=P29517	Tubulin beta-9 chain	TAS	9454836	PubMed	PTHR11588:SF245	TUBULIN BETA-4 CHAIN-RELATED
P00018	EGF receptor signaling pathway	P00558	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IGI	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000009085|UniProtKB=H2RDQ2	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00009	Axon guidance mediated by netrin	P00366	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00011	Blood coagulation	P00418	Fibrin monomer	PANTR|Ensembl=ENSPTRG00000016536|UniProtKB=H2RDH7	Uncharacterized protein	ISS	80015086	PubMed	PTHR19143:SF338	FIBRINOGEN GAMMA CHAIN
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00081	Pro-BACE-1	MONDO|Ensembl=ENSMODG00000013692|UniProtKB=F6QP52	Uncharacterized protein	ISS	10531052	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00010	B cell activation	P00384	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00056	VEGF signaling pathway	P01411	Ras	DROME|FlyBase=FBgn0003205|UniProtKB=P08646	Ras-like protein 1	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	12885769	PubMed	PTHR10202:SF13	PRESENILIN-2
P00053	T cell activation	P01332	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	IDA	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	BOVIN|Ensembl=ENSBTAG00000008216|UniProtKB=E1BI58	Uncharacterized protein	ISS			PTHR23409:SF20	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MONDO|Ensembl=ENSMODG00000007939|UniProtKB=F7G8Z6	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF26	MATRIX METALLOPROTEINASE-16
P05915	Opioid proenkephalin pathway	P05994	G-protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05915	Opioid proenkephalin pathway	P05994	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02728	Arginine biosynthesis	P02846	Ornithine carbamoyl transferase	CANLF|Ensembl=ENSCAFG00000014023|UniProtKB=E2RD27	Uncharacterized protein	ISS			PTHR11405:SF1	ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL
P00047	PDGF signaling pathway	P01150	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02738	De novo purine biosynthesis	P02905	Amidophosphoribosyl transferase	YEAST|SGD=S000004915|UniProtKB=P04046	Amidophosphoribosyltransferase	ISS			PTHR11907:SF0	AMIDOPHOSPHORIBOSYLTRANSFERASE
P00059	p53 pathway	P04630	PP2A	MOUSE|MGI=MGI=1321161|UniProtKB=P62715	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00029	Huntington disease	P00785	Cytochrome c	BOVIN|Ensembl=ENSBTAG00000012232|UniProtKB=P00125	Cytochrome c1, heme protein, mitochondrial	ISS	9027315	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00029	Huntington disease	P00805	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00010	B cell activation	P00402	Jnk	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04392	P53 pathway feedback loops 1	P04536	Mdm2	PANTR|Ensembl=ENSPTRG00000001889|UniProtKB=H2R875	Mdm4 p53 binding protein homolog	ISS			PTHR13844:SF20	PROTEIN MDM4
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	RAT|RGD=631408|UniProtKB=O88766	Neutrophil collagenase	TAS	12834808	PubMed	PTHR10201:SF137	NEUTROPHIL COLLAGENASE
P00018	EGF receptor signaling pathway	P00545	JNK1-3	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01455	Smad4	HUMAN|HGNC=6767|UniProtKB=Q15797	Mothers against decapentaplegic homolog 1	IDA	12736218	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05731	GABA-B receptor II signaling	P05754	Ggamma	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	HUMAN|HGNC=4594|UniProtKB=Q14416	Metabotropic glutamate receptor 2	ISS	9407094	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01160	IP3 receptor	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9408|UniProtKB=O94806	Serine/threonine-protein kinase D3	IGI	12676944	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00036	Interleukin signaling pathway	P00983	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00786	ARF	RAT|RGD=621270|UniProtKB=P84079	ADP-ribosylation factor 1	ISS	11752622	PubMed	PTHR11711:SF234	ADP-RIBOSYLATION FACTOR 1
P00021	FGF signaling pathway	P00642	MEK1-2	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P06664	Gonadotropin-releasing hormone receptor pathway	G06888	NOSI	MOUSE|MGI=MGI=97360|UniProtKB=Q9Z0J4	Nitric oxide synthase, brain	RCA			PTHR19384:SF63	NITRIC OXIDE SYNTHASE, BRAIN
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IDA	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00029	Huntington disease	P00786	ARF	PANTR|Ensembl=ENSPTRG00000006324|UniProtKB=H2Q894	ADP-ribosylation factor 6	ISS	11752622	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00004	Alzheimer disease-presenilin pathway	P00141	Membrane metalloprotease	MOUSE|MGI=MGI=101900|UniProtKB=P53690	Matrix metalloproteinase-14	TAS	12834808	PubMed	PTHR10201:SF24	MATRIX METALLOPROTEINASE-14
P00034	Integrin signalling pathway	P00906	Rap1	MOUSE|MGI=MGI=1919315|UniProtKB=Q8BU31	Ras-related protein Rap-2c	ISS	8576107	PubMed	PTHR24070:SF200	RAS-RELATED PROTEIN RAP-2C
P05913	Enkephalin release	P05974	G-Protein (i)	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	IC	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00005	Angiogenesis	P00223	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	STRPU|EnsemblGenome=SPU_018419|UniProtKB=W4YRI6	Uncharacterized protein	ISS	97210759	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04395	Vasopressin synthesis	P04597	Signal Peptide	RAT|RGD=3238|UniProtKB=P01179	Oxytocin-neurophysin 1	ISS	6717565	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00057	Wnt signaling pathway	P01468	APC	RAT|RGD=2123|UniProtKB=P70478	Adenomatous polyposis coli protein	IDA	12549854	PubMed	PTHR12607:SF11	ADENOMATOUS POLYPOSIS COLI PROTEIN
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	DROME|FlyBase=FBgn0010341|UniProtKB=P40793	Cdc42 homolog	ISS	9658176	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IGI	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	IC	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEEL|WormBase=WBGene00018620|UniProtKB=O44588	Uncharacterized protein	IC	3045562	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04546	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00053	T cell activation	P01305	Calmodulin	MONDO|Ensembl=ENSMODG00000025146|UniProtKB=F7CLC0	Uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF311	CALMODULIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IC	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00010	B cell activation	P00386	Calcineurin	MONDO|Ensembl=ENSMODG00000020679|UniProtKB=F7DKU1	Serine/threonine-protein phosphatase	ISS	12015605	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00013	Cell cycle	P00480	Proteasome	MACMU|Ensembl=ENSMMUG00000002132|UniProtKB=F6UPJ2	26S proteasome non-ATPase regulatory subunit 12 isoform 1	ISS	12477932	PubMed	PTHR10855:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00019	Endothelin signaling pathway	P00577	PI3K	ANOGA|Gene=AgaP_AGAP010273|UniProtKB=Q7PMF0	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00053	T cell activation	P01336	Jnk	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05915	Opioid proenkephalin pathway	P05994	G-protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00929	C3G	PANTR|Ensembl=ENSPTRG00000021490|UniProtKB=H2QY27	Uncharacterized protein	ISS	10777617	PubMed	PTHR23113:SF224	RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00018	EGF receptor signaling pathway	P00546	GAP	TAKRU|Ensembl=ENSTRUG00000005831|UniProtKB=H2SP70	Uncharacterized protein (Fragment)	ISS	99033011	PubMed	PTHR10194:SF60	NEUROFIBROMIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00021	FGF signaling pathway	P00623	FGF	MOUSE|MGI=MGI=104723|UniProtKB=P54130	Fibroblast growth factor 9	ISS			PTHR11486:SF28	FIBROBLAST GROWTH FACTOR 9
P05731	GABA-B receptor II signaling	P05755	Gbeta	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	HUMAN|HGNC=16091|UniProtKB=Q9NUB1	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ISS			PTHR24095:SF110	ACETYL-COENZYME A SYNTHETASE 2-LIKE, MITOCHONDRIAL
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	EMENI|EnsemblGenome=CADANIAG00006296|UniProtKB=Q5ASG1	Putative synaptobrevin homologue SNC1/2 (Eurofung)	ISS			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	RCA	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04393	Ras Pathway	P04569	Cdc42	DANRE|ZFIN=ZDB-GENE-030131-8783|UniProtKB=Q52WY2	Ras-like protein Cdc42a	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CHICK|Ensembl=ENSGALG00000014620|UniProtKB=F1N8P3	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00012	Cadherin signaling pathway	P00470	F-actin	ORYSJ|EnsemblGenome=OS03G0718100|UniProtKB=Q10DV7	Actin-1	IC	14684598	PubMed	PTHR11937:SF364	ACTIN-11
P06664	Gonadotropin-releasing hormone receptor pathway	P06782	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	RCA	8787761	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01417	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	XENTR|Xenbase=XB-GENE-957124|UniProtKB=F7BDN8	Uncharacterized protein	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00384	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	MACMU|Ensembl=ENSMMUG00000017017|UniProtKB=F7FVL2	Tyrosine-protein kinase	ISS	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00021	FGF signaling pathway	P00628	JNK1-3	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS			PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00045	Notch signaling pathway	P01117	Neuralized	XENTR|Xenbase=XB-GENE-954449|UniProtKB=A1A5F8	Neurl protein	ISS	11740941	PubMed	PTHR12429:SF13	E3 UBIQUITIN-PROTEIN LIGASE NEURL1
P00021	FGF signaling pathway	P00628	JNK1-3	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04397	p53 pathway by glucose deprivation	P04636	S6K	CHICK|Ensembl=ENSGALG00000005198|UniProtKB=F1P4J0	Ribosomal protein S6 kinase	IDA	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00048	PI3 kinase pathway	P01188	Gbetagamma	ANOGA|EnsemblGenome=AGAP005912|UniProtKB=Q7Q6D3	AGAP005912-PA	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00019	Endothelin signaling pathway	P00580	ET-RA/B	ORNAN|Ensembl=ENSOANG00000005262|UniProtKB=F6VIX5	Uncharacterized protein	ISS			PTHR24243:SF31	ENDOTHELIN-1 RECEPTOR
P05734	Synaptic vesicle trafficking	P05779	Synaptobrevin	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IDA	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00048	PI3 kinase pathway	P01192	p110	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DROME|FlyBase=FBgn0260862|UniProtKB=Q9W0N6	LD27967p	ISS	10908612	PubMed	PTHR21230:SF39	VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04495	TSC1	HUMAN|HGNC=12362|UniProtKB=Q92574	Hamartin	IDA	12167664	PubMed	PTHR15154:SF2	HAMARTIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	IC	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00021	FGF signaling pathway	P00629	PP2A	MOUSE|MGI=MGI=1920180|UniProtKB=Q6ZWR4	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform	ISS	12110603	PubMed	PTHR11871:SF1	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B BETA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00034	Integrin signalling pathway	P00907	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01206	14-3-3	MONDO|Ensembl=ENSMODG00000015951|UniProtKB=F7FRT9	Uncharacterized protein	ISS	12861023	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00053	T cell activation	P01331	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00029	Huntington disease	P00796	Kainate receptor	CANLF|Ensembl=ENSCAFG00000003333|UniProtKB=F1PWT6	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00029	Huntington disease	P00790	beta-Tubulin	NEMVE|Gene=v1g118944|UniProtKB=A7SHY4	Predicted protein (Fragment)	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00006	Apoptosis signaling pathway	P00274	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	XENTR|Xenbase=XB-GENE-999035|UniProtKB=F7CEB1	Uncharacterized protein	ISS	10956649	PubMed	PTHR42884:SF1	FURIN
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	RAT|RGD=3381|UniProtKB=P62716	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	TAKRU|Ensembl=ENSTRUG00000003442|UniProtKB=H2S6Q5	Uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF197	CALMODULIN-LIKE PROTEIN 3
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00005	Angiogenesis	P00183	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	7680960	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00047	PDGF signaling pathway	P01140	ELK	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	ISS	9644975	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00037	Ionotropic glutamate receptor pathway	P01018	Glu1	PANTR|Ensembl=ENSPTRG00000017441|UniProtKB=H2QRU7	Glutamate receptor, ionotropic, AMPA 1	ISS	12871085	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P02762	Pentose phosphate pathway	P03082	Transketolase	HUMAN|HGNC=11834|UniProtKB=P29401	Transketolase	RCA			PTHR43195:SF3	TRANSKETOLASE
P00038	JAK/STAT signaling pathway	P01029	Serine kinase	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS			PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06006	beta-Endorphin	MACMU|Ensembl=ENSMMUG00000016463|UniProtKB=F7GBI0	Uncharacterized protein	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	CANLF|Ensembl=ENSCAFG00000017575|UniProtKB=Q076A5	Myosin-4	ISS	10938134	PubMed	PTHR13140:SF657	MYOSIN-4
P00025	Hedgehog signaling pathway	P00682	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	DROME|FlyBase=FBgn0030011|UniProtKB=Q9W3J1	Gbeta5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	ORYSJ|EnsemblGenome=OS01G0591300|UniProtKB=Q94JC6	Os01g0591300 protein	IC			PTHR11699:SF182	ALDEHYDE DEHYDROGENASE FAMILY 2 MEMBER C4
P02783	Tryptophan biosynthesis	P03206	Anthranilate synthase	THEKO|EnsemblGenome=TK0254|UniProtKB=Q9YGB3	Anthranilate synthase component 1	ISS			PTHR11236:SF9	ANTHRANILATE SYNTHASE COMPONENT 1
P00034	Integrin signalling pathway	P00919	Arf6	RAT|RGD=621279|UniProtKB=P62332	ADP-ribosylation factor 6	ISS	12932731	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00049	Parkinson disease	P01238	14-3-3	DANRE|ZFIN=ZDB-GENE-050306-44|UniProtKB=Q5CZQ1	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2	ISS	8024705	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05731	GABA-B receptor II signaling	P05752	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00474	Wnt	RAT|RGD=69346|UniProtKB=G3V7U3	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00006	Apoptosis signaling pathway	P00285	Diva	MOUSE|MGI=MGI=1330841|UniProtKB=Q9Z0F3	Bcl-2-like protein 10	IDA	9829980	PubMed	PTHR11256:SF47	BCL-2-LIKE PROTEIN 10
P00037	Ionotropic glutamate receptor pathway	P01026	KA	ORNAN|Ensembl=ENSOANG00000002061|UniProtKB=F7ANC6	Uncharacterized protein	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00015	Circadian clock system	P00501	Clock	BOVIN|Ensembl=ENSBTAG00000044044|UniProtKB=F1MLT7	Uncharacterized protein	ISS	10198158	PubMed	PTHR23042:SF2	CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT
P00047	PDGF signaling pathway	P01148	Grb2	XENTR|Xenbase=XB-GENE-6070000|UniProtKB=Q66II3	Growth factor receptor-bound protein 2	ISS	12748278	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P05915	Opioid proenkephalin pathway	P05993	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P05730	Endogenous cannabinoid signaling	P05746	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	TAKRU|Ensembl=ENSTRUG00000011297|UniProtKB=H2TV18	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00047	PDGF signaling pathway	P01161	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04395	Vasopressin synthesis	P04597	Signal Peptide	PANTR|Ensembl=ENSPTRG00000013189|UniProtKB=H2QJV1	Uncharacterized protein	ISS	9756087	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P02783	Tryptophan biosynthesis	P03210	Indole-3-glycerol phosphate synthase	BACTN|EnsemblGenome=BT_0529|UniProtKB=Q8AAD6	Indole-3-glycerol phosphate synthase	ISS			PTHR22854:SF2	TRYPTOPHAN BIOSYNTHESIS PROTEIN TRPCF
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00022	General transcription by RNA polymerase I	P00649	TAF-IC	HUMAN|HGNC=17300|UniProtKB=Q7Z7C8	Transcription initiation factor TFIID subunit 8	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	YEAST|SGD=S000002874|UniProtKB=Q03306	Serine/threonine-protein kinase PKH3	ISS			PTHR24356:SF238	SERINE/THREONINE-PROTEIN KINASE PKH3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	RAT|RGD=61862|UniProtKB=P19491	Glutamate receptor 2	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00029	Huntington disease	P00775	Rac	PRIPA|Gene=PPA22610|UniProtKB=H3FK05	Uncharacterized protein	ISS			PTHR24072:SF192	CDC42 HOMOLOG
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00973	PKB	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00256	PLC-gamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2344|UniProtKB=P08485	Muscarinic acetylcholine receptor M4	IDA	12181435	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00807	Actin	STRPU|Gene=CYIIIA|UniProtKB=P53474	Actin, cytoskeletal 3A	IDA	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P02738	De novo purine biosynthesis	P02904	Guanylate kinase	DEIRA|EnsemblGenome=DR_2289|UniProtKB=Q9RS38	Guanylate kinase	ISS			PTHR23117:SF13	GUANYLATE KINASE
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	HUMAN|HGNC=8592|UniProtKB=O75914	Serine/threonine-protein kinase PAK 3	ISS	11259591	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MONDO|Ensembl=ENSMODG00000015364|UniProtKB=F6WHM2	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P00012	Cadherin signaling pathway	P00464	Fyn	TAKRU|Ensembl=ENSTRUG00000014739|UniProtKB=H2UL58	Tyrosine-protein kinase	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00005	Angiogenesis	P00193	SOS-1	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS			PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05753	Ca channel	BOVIN|Ensembl=ENSBTAG00000007882|UniProtKB=G3X7Z2	Uncharacterized protein	ISS	11976940	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00005	Angiogenesis	P00201	FVIIa	HUMAN|HGNC=3544|UniProtKB=P08709	Coagulation factor VII	IDA	11487022	PubMed	PTHR44064:SF1	COAGULATION FACTOR VII
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	CAEEL|WormBase=WBGene00002335|UniProtKB=P22981	Ras protein let-60	ISS	12024031	PubMed	PTHR24070:SF385	GTPASE HRAS
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00056	VEGF signaling pathway	P01425	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CANLF|Ensembl=ENSCAFG00000005662|UniProtKB=E2R907	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000035697|UniProtKB=Q28024	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	CANLF|Ensembl=ENSCAFG00000013171|UniProtKB=E2RP04	Uncharacterized protein	ISS	10558991	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00036	Interleukin signaling pathway	P00987	SRF	MACMU|Ensembl=ENSMMUG00000000033|UniProtKB=F7G4D2	Uncharacterized protein	ISS	15170389	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00012	Cadherin signaling pathway	P00470	F-actin	MOUSE|MGI=MGI=1913963|UniProtKB=P61161	Actin-related protein 2	ISS	11889126	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P02774	Salvage pyrimidine deoxyribonucleotides	P03146	Deoxyuridine kinase	BACSU|EnsemblGenome=BSU37060|UniProtKB=Q03221	Thymidine kinase	ISS			PTHR11441:SF0	THYMIDINE KINASE, CYTOSOLIC
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00774	Dynein complex	DROME|FlyBase=FBgn0030276|UniProtKB=Q9VZ20	Dynein light intermediate chain, isoform A	IPI	9454836	PubMed	PTHR12688:SF0	DYNEIN LIGHT INTERMEDIATE CHAIN, ISOFORM A
P00019	Endothelin signaling pathway	P00590	IP3 R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00865	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	95096035	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	BOVIN|Ensembl=ENSBTAG00000031837|UniProtKB=Q3SWY3	Inosine-5'-monophosphate dehydrogenase 2	ISS			PTHR11911:SF121	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2
P00010	B cell activation	P00391	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01192	p110	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01159	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00321	HSP70	CAEBR|Gene=CBG13234|UniProtKB=A8XHD1	Protein CBG13234	ISS	12150907	PubMed	PTHR19375:SF256	HSP70 PROTEIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	BOVIN|Gene=SLC1A1|UniProtKB=Q95135	Excitatory amino acid transporter 3	ISS	96032356	PubMed	PTHR11958:SF69	EXCITATORY AMINO ACID TRANSPORTER 3
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	ECOLI|EcoGene=EG11362|UniProtKB=P27305	Glutamyl-Q tRNA(Asp) synthetase	ISS			PTHR43311:SF1	GLUTAMYL-Q TRNA ASP  SYNTHETASE
P00003	Alzheimer disease-amyloid secretase pathway	P00084	X11alpha	CANLF|Ensembl=ENSCAFG00000010382|UniProtKB=F1PP27	Uncharacterized protein	ISS	9614075	PubMed	PTHR12345:SF12	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 2
P02751	Lysine biosynthesis	P03012	N-succinyl-diaminopimelate desuccinylase	ECOLI|EcoGene=EG10208|UniProtKB=P0AED7	Succinyl-diaminopimelate desuccinylase	ISS			PTHR43270:SF9	SUCCINYL-DIAMINOPIMELATE DESUCCINYLASE
P04393	Ras Pathway	P04542	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02742	Tetrahydrofolate biosynthesis	P02944	Phosphoribosylglycinamide formyltransferase	DEIRA|EnsemblGenome=DR_2026|UniProtKB=Q9RSU6	Phosphoribosylglycinamide formyltransferase	ISS			PTHR43369:SF2	PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE
P02741	Flavin biosynthesis	P02936	FAD synthetase	SCHPO|PomBase=SPCC18.16c|UniProtKB=O74866	Riboflavin kinase	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P00029	Huntington disease	P00773	Duo	BOVIN|Ensembl=ENSBTAG00000002640|UniProtKB=F1MXJ6	Uncharacterized protein	ISS	9285789	PubMed	PTHR22826:SF49	KALIRIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	RAT|RGD=619965|UniProtKB=P26769	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00047	PDGF signaling pathway	P01164	PDK1/2	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	ISS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00552	Ras	CAEEL|WormBase=WBGene00004310|UniProtKB=G5EBK8	GTP binding protein	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00029	Huntington disease	P00807	Actin	ARATH|TAIR=AT3G18780|UniProtKB=Q96292	Actin-2	IDA	14684598	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000008751|UniProtKB=H2QC89	Uncharacterized protein	ISS	12507995	PubMed	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	RAT|RGD=2026|UniProtKB=P68035	Actin, alpha cardiac muscle 1	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	91072385	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	MOUSE|MGI=MGI=106677|UniProtKB=Q8BRU6	Synaptic vesicular amine transporter	ISS	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	RAT|RGD=2246|UniProtKB=Q07652	Voltage-dependent R-type calcium channel subunit alpha-1E	IDA	11976940	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02736	Coenzyme A biosynthesis	P02885	Pantothenate kinase	CAEBR|Gene=CBG12583|UniProtKB=A8XG37	Protein CBR-PNK-1	ISS			PTHR12280:SF20	PANTOTHENATE KINASE 4
P00053	T cell activation	P01324	rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05917	Opioid proopiomelanocortin pathway	P06008	ACTH	HUMAN|HGNC=9201|UniProtKB=P01189	Pro-opiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00034	Integrin signalling pathway	P00922	Collagen	ORNAN|Ensembl=ENSOANG00000003903|UniProtKB=F6ZCA5	Uncharacterized protein	ISS	10778855	PubMed	PTHR24023:SF387	COLLAGEN ALPHA-1 V  CHAIN
P00053	T cell activation	P01332	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	IDA	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	ORNAN|Ensembl=ENSOANG00000000514|UniProtKB=F7CVF2	Uncharacterized protein	ISS	11034345	PubMed	PTHR11647:SF58	DIHYDROPYRIMIDINASE-RELATED PROTEIN 5
P00004	Alzheimer disease-presenilin pathway	P00174	CD44 N-terminal fragment	HUMAN|HGNC=1681|UniProtKB=P16070	CD44 antigen	IDA	14871815	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P00047	PDGF signaling pathway	P01154	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00005	Angiogenesis	P00253	Axin	PANTR|Ensembl=ENSPTRG00000009554|UniProtKB=H2QDP9	Uncharacterized protein	ISS	9554852	PubMed	PTHR10845:SF103	AXIN-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	RAT|RGD=1593806|UniProtKB=G3V8Y0	Protein Gng13	ISS	10391901	PubMed	PTHR15936:SF2	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-13
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00048	PI3 kinase pathway	P01188	Gbetagamma	PHYIT|EnsemblGenome=PITG_06376|UniProtKB=D0N4Q3	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta, putative	IC	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01148	Grb2	CAEBR|Gene=CBG16856|UniProtKB=A8XPY6	Protein CBR-SEM-5	ISS	17569445	gi	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P02721	ATP synthesis	P02791	F1 alpha	CHICK|Ensembl=ENSGALG00000001756|UniProtKB=F1NGA2	ATP synthase subunit alpha	ISS	11479684	PubMed	PTHR43089:SF5	ATP SYNTHASE SUBUNIT ALPHA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00004	Alzheimer disease-presenilin pathway	P00165	E-cadherin N-terminal fragment	PANTR|Ensembl=ENSPTRG00000008269|UniProtKB=H2QBE4	Cadherin 3, type 1, P-cadherin (Placental)	ISS	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P00029	Huntington disease	P00807	Actin	ORNAN|Ensembl=ENSOANG00000007581|UniProtKB=F6QWB7	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	CHICK|Ensembl=ENSGALG00000000898|UniProtKB=Q5ZHP3	Cilia- and flagella-associated protein 20	ISS			PTHR12458:SF8	CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20
P05918	p38 MAPK pathway	P06029	p38beta	BOVIN|Ensembl=ENSBTAG00000030182|UniProtKB=G3X793	Mitogen-activated protein kinase	ISS	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00036	Interleukin signaling pathway	P00990	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	IDA	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	PANTR|Ensembl=ENSPTRG00000002256|UniProtKB=H2Q1K5	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF197	CALMODULIN-LIKE PROTEIN 3
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00189	Fzd	PANTR|Ensembl=ENSPTRG00000009279|UniProtKB=H2QD74	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF34	FRIZZLED-2
P02738	De novo purine biosynthesis	P02892	5-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase	MYCTU|EnsemblGenome=LH57_04215|UniProtKB=I6XWA1	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CAEEL|WormBase=WBGene00000050|UniProtKB=P91197	AcetylCholine Receptor	IC	11404397	PubMed	PTHR18945:SF436	ACETYLCHOLINE RECEPTOR
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	TAS	9851932	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95811|UniProtKB=Q9Z2W8	Glutamate receptor 4	ISS	12871085	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CAEBR|Gene=CBG05896|UniProtKB=A8X1E0	Phosphoinositide phospholipase C	ISS			PTHR10336:SF147	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-2
P00018	EGF receptor signaling pathway	P00540	MKK3,6	BOVIN|Ensembl=ENSBTAG00000001609|UniProtKB=Q5E9X2	Dual specificity mitogen-activated protein kinase kinase 6	ISS	8622669	PubMed	PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P00018	EGF receptor signaling pathway	P00547	PP2A	BOVIN|Ensembl=ENSBTAG00000020192|UniProtKB=A4FV55	PPP2R5C protein	ISS	8576224	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00790	beta-Tubulin	SCLS1|EnsemblGenome=SS1G_04652|UniProtKB=A7EH60	Beta tubulin	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04393	Ras Pathway	P04560	AP1	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	MACMU|Ensembl=ENSMMUG00000010184|UniProtKB=F6SR09	Uncharacterized protein	ISS	92317054	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	14744428	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	BOVIN|Ensembl=ENSBTAG00000015252|UniProtKB=F1MDD1	Uncharacterized protein	ISS			PTHR18945:SF489	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-9
P05730	Endogenous cannabinoid signaling	P05746	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	DROME|FlyBase=FBgn0032593|UniProtKB=Q9VJJ7	Transient receptor potential-gamma protein	IDA	11055438	PubMed	PTHR10117:SF54	TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN
P00021	FGF signaling pathway	P00646	RasGAP	MOUSE|MGI=MGI=1330842|UniProtKB=Q9Z268	RasGAP-activating-like protein 1	ISS	13529338	gi	PTHR10194:SF3	RASGAP-ACTIVATING-LIKE PROTEIN 1
P00005	Angiogenesis	P00238	Ras	MONDO|Ensembl=ENSMODG00000025248|UniProtKB=F7F5X1	Uncharacterized protein	ISS	9869449	PubMed	PTHR24070:SF186	GTPASE KRAS
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IDA			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00053	T cell activation	P01324	rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00555	MKK4,7	HUMAN|HGNC=6844|UniProtKB=P45985	Dual specificity mitogen-activated protein kinase kinase 4	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00019	Endothelin signaling pathway	P00578	eNOS	PANTR|Ensembl=ENSPTRG00000019868|UniProtKB=H2QVM2	Nitric oxide synthase	ISS	22462730	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00005	Angiogenesis	P00206	Wnt	MOUSE|MGI=MGI=108061|UniProtKB=P48614	Protein Wnt-10b	ISS	8717036	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00475	Frizzled	DROME|FlyBase=FBgn0027342|UniProtKB=Q9NBW1	Frizzled-4	IDA	8717036	PubMed	PTHR11309:SF23	FRIZZLED-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	HUMAN|HGNC=1953|UniProtKB=P08173	Muscarinic acetylcholine receptor M4	TAS	11166329	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00036	Interleukin signaling pathway	P00964	p90RSK	HUMAN|HGNC=10430|UniProtKB=Q15418	Ribosomal protein S6 kinase alpha-1	ISS	6755374	gi	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P02757	O-antigen biosynthesis	P03050	dTDP-4-dehydrorhamnose reductase	NEUCR|EnsemblGenome=EFNCRG00000004340|UniProtKB=Q1K857	NAD dependent epimerase/dehydratase	ISS			PTHR10491:SF4	METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA
P00005	Angiogenesis	P00256	PLC-gamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	MACMU|Ensembl=ENSMMUG00000019917|UniProtKB=F6SEF6	Uncharacterized protein	ISS	600075	OMIM	PTHR10126:SF20	TATA-BOX-BINDING PROTEIN
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	BOVIN|Ensembl=ENSBTAG00000002125|UniProtKB=F1N461	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P06664	Gonadotropin-releasing hormone receptor pathway	P06850	PKCs(3)	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT1G10210|UniProtKB=Q39021	Mitogen-activated protein kinase 1	ISS	10851062	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	RCA	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00019	Endothelin signaling pathway	P00568	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00034	Integrin signalling pathway	P00906	Rap1	MOUSE|MGI=MGI=97852|UniProtKB=P62835	Ras-related protein Rap-1A	ISS	8576107	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P04393	Ras Pathway	P04557	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=61800|UniProtKB=P14842	5-hydroxytryptamine receptor 2A	IDA			PTHR24247:SF30	5-HYDROXYTRYPTAMINE RECEPTOR 2A
P05913	Enkephalin release	P05976	Enkephalin	DANRE|ZFIN=ZDB-GENE-030729-31|UniProtKB=A8E7S2	Uncharacterized protein	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05731	GABA-B receptor II signaling	P05754	Ggamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	RAT|RGD=3876|UniProtKB=P16599	Tumor necrosis factor	ISS	11911478	PubMed	PTHR11471:SF23	TUMOR NECROSIS FACTOR
P00010	B cell activation	P00375	Calmodulin	ARATH|TAIR=AT3G43810|UniProtKB=P59220	Calmodulin-7	ISS	9753452	PubMed	PTHR23050:SF250	CALMODULIN-7
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	RAT|RGD=2246|UniProtKB=Q07652	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	14624853	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00021	FGF signaling pathway	P00633	Ras	DANRE|ZFIN=ZDB-GENE-040808-67|UniProtKB=Q6AZA4	K-ras	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P05734	Synaptic vesicle trafficking	P05770	Munc18	PANTR|Ensembl=ENSPTRG00000021392|UniProtKB=H2R6A8	Uncharacterized protein	ISS	8108429	PubMed	PTHR11679:SF35	SYNTAXIN-BINDING PROTEIN 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000022548|UniProtKB=F6Y9J9	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P02775	Salvage pyrimidine ribonucleotides	P03155	Cytosine deaminase	ECOLI|EcoGene=EG11372|UniProtKB=P68398	tRNA-specific adenosine deaminase	ISS			PTHR11079:SF149	TRNA-SPECIFIC ADENOSINE DEAMINASE
P00054	Toll receptor signaling pathway	P01375	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00029	Huntington disease	P00811	Arp2/3 complex	HUMAN|HGNC=704|UniProtKB=O15143	Actin-related protein 2/3 complex subunit 1B	TAS	9618202	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	SCLS1|EnsemblGenome=SS1G_03482|UniProtKB=A7EDU2	Guanine nucleotide-binding protein beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00034	Integrin signalling pathway	P00948	Rho	TAKRU|Ensembl=ENSTRUG00000011944|UniProtKB=H2TZX5	Uncharacterized protein	ISS	10556059	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00036	Interleukin signaling pathway	P00973	PKB	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	TAS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00560	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00767	Pro-caspase 8	MACMU|Ensembl=ENSMMUG00000031296|UniProtKB=F7C587	Uncharacterized protein	ISS	8681376	PubMed	PTHR10454:SF162	CASPASE-8
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05913	Enkephalin release	P05977	G-Protein (s)	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00049	Parkinson disease	P01215	Syntaxin	MACMU|Ensembl=ENSMMUG00000004994|UniProtKB=F7ATP9	Syntaxin-7	ISS	14570579	PubMed	PTHR19957:SF90	SYNTAXIN-7
P00036	Interleukin signaling pathway	P00994	FKHRL1	HUMAN|HGNC=3821|UniProtKB=O43524	Forkhead box protein O3	TAS	12884295	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000001583|UniProtKB=F7BBM1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	RAT|RGD=619751|UniProtKB=O88302	Guanine nucleotide-binding protein subunit alpha-15	ISS	11534853	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	PANTR|Ensembl=ENSPTRG00000012813|UniProtKB=H2QJ90	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF31	FRIZZLED-7
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00019	Endothelin signaling pathway	P00591	PLCbeta	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00048	PI3 kinase pathway	P01190	PDK1 ACT	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	9094314	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01188	Gbetagamma	EMENI|EnsemblGenome=CADANIAG00002670|UniProtKB=Q5BH99	G-protein beta subunit [Source:UniProtKB/TrEMBLAcc:O74214]	IC	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	HUMAN|HGNC=4572|UniProtKB=P42262	Glutamate receptor 2	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DICDI|dictyBase=DDB_G0283907|UniProtKB=P34099	cAMP-dependent protein kinase catalytic subunit	IC	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	ORYSJ|EnsemblGenome=OS03G0105600|UniProtKB=Q8H7U1	Tubulin beta-2 chain	ISS	9454836	PubMed	PTHR11588:SF178	TUBULIN BETA-7 CHAIN
P00047	PDGF signaling pathway	P01153	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT4G36450|UniProtKB=O23236	Mitogen-activated protein kinase 14	IDA	12787066	PubMed	PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00633	Ras	DICDI|dictyBase=DDB_G0292996|UniProtKB=P03967	Ras-like protein rasD	IDA	6091907	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	CANLF|Ensembl=ENSCAFG00000004381|UniProtKB=J9JH96	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00021	FGF signaling pathway	P00645	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	10891487	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00018	EGF receptor signaling pathway	P00547	PP2A	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g195622|UniProtKB=A7T2Q5	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=278|UniProtKB=P35368	Alpha-1B adrenergic receptor	IDA			PTHR24248:SF17	ALPHA-1B ADRENERGIC RECEPTOR
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00021	FGF signaling pathway	P00647	SHP2	CANLF|Ensembl=ENSCAFG00000008894|UniProtKB=F1Q3J6	Tyrosine-protein phosphatase non-receptor type	ISS	8096088	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00013	Cell cycle	P00480	Proteasome	CANLF|Ensembl=ENSCAFG00000014716|UniProtKB=E2RPY9	Uncharacterized protein	ISS	9218537	PubMed	PTHR10660:SF4	PROTEASOME ACTIVATOR COMPLEX SUBUNIT 3
P00005	Angiogenesis	P00229	SPK	BOVIN|Ensembl=ENSBTAG00000009872|UniProtKB=E1BJM1	Uncharacterized protein	ISS			PTHR12358:SF40	SPHINGOSINE KINASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=88397|UniProtKB=Q9ERZ4	Muscarinic acetylcholine receptor M2	IDA	11166329	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05918	p38 MAPK pathway	P06020	p38delta	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01173	STAT	TAKRU|Ensembl=ENSTRUG00000011114|UniProtKB=H2TTP1	Signal transducer and activator of transcription	ISS			PTHR11801:SF19	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 4
P06664	Gonadotropin-releasing hormone receptor pathway	P06784	Paxillin	MOUSE|MGI=MGI=108295|UniProtKB=Q8VI36	Paxillin	RCA	9182576	PubMed	PTHR24216:SF11	PAXILLIN
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00059	p53 pathway	G04697	B99	MOUSE|MGI=MGI=1352755|UniProtKB=Q8R080	G2 and S phase-expressed protein 1	ISS	20127556	gi	PTHR21584:SF10	G2 AND S PHASE-EXPRESSED PROTEIN 1
P00059	p53 pathway	P04618	PML	HUMAN|HGNC=9113|UniProtKB=P29590	Protein PML	IDA	12810724	PubMed	PTHR45211:SF1	PROTEIN PML
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=3346|UniProtKB=P10688	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	10934033	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00018	EGF receptor signaling pathway	P00539	14-3-3	SCHMA|EnsemblGenome=Smp_002410|UniProtKB=Q95W36	14-3-3 epsilon 2	IGI	12062487	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00034	Integrin signalling pathway	P00925	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	SCHMA|EnsemblGenome=Smp_202970|UniProtKB=G4VLN1	Putative uncharacterized protein Smp_202970	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00470	F-actin	DICDI|dictyBase=DDB_G0275023|UniProtKB=Q553U6	Putative actin-22	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DICDI|dictyBase=DDB_G0279605|UniProtKB=P34148	Rho-related protein racB	ISS	11973360	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P02738	De novo purine biosynthesis	P02898	Phosphoribosylformylglycinamide  synthase	SYNY3|EnsemblGenome=BAA16646|UniProtKB=P72644	Phosphoribosylformylglycinamidine synthase subunit PurL	ISS			PTHR43555:SF1	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00207	Crk	ANOGA|EnsemblGenome=AGAP009499|UniProtKB=Q7QG48	AGAP009499-PA	ISS			PTHR19969:SF5	ADAPTER MOLECULE CRK
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00223	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01177	P110ACT	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	15621031	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00048	PI3 kinase pathway	P01190	PDK1 ACT	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	IDA	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00012	Cadherin signaling pathway	P00476	Yes	CANLF|Ensembl=ENSCAFG00000007034|UniProtKB=E2RBB8	Tyrosine-protein kinase	ISS			PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P00034	Integrin signalling pathway	P00922	Collagen	BOVIN|Ensembl=ENSBTAG00000013369|UniProtKB=E1BA17	Uncharacterized protein	ISS	10778855	PubMed	PTHR44557:SF1	COLLAGEN ALPHA-1 XIV  CHAIN
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05959	FLNA	RAT|RGD=1560614|UniProtKB=C0JPT7	Filamin alpha	ISS	11911837	PubMed	PTHR43998:SF6	FILAMIN-A
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MONDO|Ensembl=ENSMODG00000010521|UniProtKB=F7DQK7	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	YEAST|SGD=S000000950|UniProtKB=P13393	TATA-box-binding protein	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00009	Axon guidance mediated by netrin	P00356	UNC-5	HUMAN|HGNC=12568|UniProtKB=Q8IZJ1	Netrin receptor UNC5B	ISS			PTHR12582:SF6	NETRIN RECEPTOR UNC5B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MOUSE|MGI=MGI=1918979|UniProtKB=Q8CGE9	Regulator of G-protein signaling 12	ISS	8756726	PubMed	PTHR10845:SF149	REGULATOR OF G-PROTEIN SIGNALING 12
P04393	Ras Pathway	P04558	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IDA	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04393	Ras Pathway	P04567	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00052	TGF-beta signaling pathway	P01284	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IDA	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02721	ATP synthesis	P02798	Cyt C	CHLRE|EnsemblGenome=CHLREDRAFT_176233|UniProtKB=A8J5T0	Mitochondrial cytochrome c	ISS	2853233	PubMed	PTHR11961:SF12	CYTOCHROME C
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02770	Pyridoxal phosphate salvage pathway	P03122	Pyridoxamine kinase	ECOLI|EcoGene=EG12642|UniProtKB=P40191	Pyridoxine/pyridoxal/pyridoxamine kinase	ISS	11206551	PubMed	PTHR10534:SF13	PYRIDOXINE/PYRIDOXAL/PYRIDOXAMINE KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	TAS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MACMU|Ensembl=ENSMMUG00000007027|UniProtKB=F7F210	Alpha-cardiac actin	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00922	Collagen	MOUSE|MGI=MGI=2152695|UniProtKB=B1AVK5	Protein Col4a6	IDA	10778855	PubMed	PTHR24023:SF533	COLLAGEN ALPHA-6 IV  CHAIN
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	18021322	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	HUMAN|HGNC=8861|UniProtKB=P02776	Platelet factor 4	ISS	9910486	gi	PTHR10179:SF43	PLATELET FACTOR 4
P00020	FAS signaling pathway	P00615	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	RCA	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00021	FGF signaling pathway	P00640	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00798	Clathrin	DROME|FlyBase=FBgn0024814|UniProtKB=Q9VWA1	Clathrin light chain	IDA	11889126	PubMed	PTHR10639:SF7	CLATHRIN LIGHT CHAIN
P00054	Toll receptor signaling pathway	P01375	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	CHICK|Ensembl=ENSGALG00000009403|UniProtKB=E1BQG4	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF27	G PROTEIN-COUPLED RECEPTOR KINASE 5
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P02749	Leucine biosynthesis	P03002	Isopropylmalate isomerase	ECOLI|EcoGene=EG11576|UniProtKB=P0A6A6	3-isopropylmalate dehydratase large subunit	ISS			PTHR43822:SF2	HOMOACONITASE, MITOCHONDRIAL
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	DAPPU|EnsemblGenome=DAPPUDRAFT_301818|UniProtKB=E9I1I7	Putative uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00566	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	RAT|RGD=620200|UniProtKB=P80201	Activin receptor type-1	TAS	9395284	PubMed	PTHR23255:SF69	ACTIVIN RECEPTOR TYPE-1
P00047	PDGF signaling pathway	P01151	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MONDO|Ensembl=ENSMODG00000015573|UniProtKB=F7AIP6	Uncharacterized protein (Fragment)	ISS	12356903	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00021	FGF signaling pathway	P00648	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00045	Notch signaling pathway	P01117	Neuralized	MOUSE|MGI=MGI=1921092|UniProtKB=Q5NCX5	Neuralized-like protein 4	RCA			PTHR12429:SF14	NEURALIZED-LIKE PROTEIN 4
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000012036|UniProtKB=F7ALP1	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00029	Huntington disease	P00780	Microtubule	ANOGA|EnsemblGenome=AGAP010929|UniProtKB=Q7PSI4	AGAP010929-PA	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04387	Histamine synthesis	P04493	Histidine decarboxylase	CANLF|Ensembl=ENSCAFG00000015072|UniProtKB=E2RMU1	Uncharacterized protein	ISS	1702422	PubMed	PTHR11999:SF68	HISTIDINE DECARBOXYLASE
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IGI	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P02747	Histidine biosynthesis	P02984	Imidazol glycerol phosphate dehydratase	NEUCR|EnsemblGenome=EFNCRG00000004049|UniProtKB=Q9HEG3	Imidazoleglycerol-phosphate dehydratase	ISS			PTHR23133:SF2	IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE
P00057	Wnt signaling pathway	P01440	Cadherin	DANRE|ZFIN=ZDB-GENE-990415-171|UniProtKB=Q90275	Cadherin-2	IDA	8120095	PubMed	PTHR24027:SF79	CADHERIN-2
P00018	EGF receptor signaling pathway	P00546	GAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02778	Sulfate assimilation	P03167	Sulfate adenylyltransferase	YEAST|SGD=S000003771|UniProtKB=P08536	Sulfate adenylyltransferase	ISS			PTHR42700:SF1	SULFATE ADENYLYLTRANSFERASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CANLF|Ensembl=ENSCAFG00000017575|UniProtKB=Q076A5	Myosin-4	ISS	10938134	PubMed	PTHR13140:SF657	MYOSIN-4
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IDA	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00036	Interleukin signaling pathway	P00965	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00054	Toll receptor signaling pathway	P01369	MKK1	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MOUSE|MGI=MGI=1341110|UniProtKB=P97490	Adenylate cyclase type 8	IDA	12890691	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_127490|UniProtKB=C3XYC5	Putative uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CHICK|Ensembl=ENSGALG00000028749|UniProtKB=Q5ZMQ2	Actin, cytoplasmic 2	ISS	11889139	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	PANTR|Ensembl=ENSPTRG00000016800|UniProtKB=H2QQS3	Solute carrier family 1 (Glial high affinity glutamate transporter), member 3	ISS	96032356	PubMed	PTHR11958:SF24	EXCITATORY AMINO ACID TRANSPORTER 1
P00047	PDGF signaling pathway	P01142	p90RSK	CHICK|Ensembl=ENSGALG00000011473|UniProtKB=F1P1H2	Ribosomal protein S6 kinase	ISS	15526037	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00021	FGF signaling pathway	P00645	Rac	ANOGA|EnsemblGenome=AGAP001573|UniProtKB=Q380U3	AGAP001573-PA	ISS			PTHR24072:SF157	AT17867P
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00017	DNA replication	P00527	Histones	CHLRE|EnsemblGenome=CHLREDRAFT_581|UniProtKB=A8J9M0	Histone H3	ISS	12413958	PubMed	PTHR11426:SF169	HISTONE H3
P00005	Angiogenesis	P00238	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P06664	Gonadotropin-releasing hormone receptor pathway	G06682	Isl-1	HUMAN|HGNC=6132|UniProtKB=P61371	Insulin gene enhancer protein ISL-1	RCA			PTHR24204:SF3	INSULIN GENE ENHANCER PROTEIN ISL-1
P00010	B cell activation	P00383	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00020	FAS signaling pathway	P00607	Pro-Caspase6	CHICK|Ensembl=ENSGALG00000012186|UniProtKB=F1NEL6	Uncharacterized protein	IGI	10770929	PubMed	PTHR10454:SF164	CASPASE-6
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00056	VEGF signaling pathway	P01407	Erk	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	12471242	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00648	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04398	p53 pathway feedback loops 2	P04665	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	TAS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00029	Huntington disease	P00771	Sin3A	MONDO|Ensembl=ENSMODG00000008922|UniProtKB=F7BFR8	Uncharacterized protein	ISS	10441327	PubMed	PTHR12346:SF2	PAIRED AMPHIPATHIC HELIX PROTEIN SIN3A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	EMENI|EnsemblGenome=CADANIAG00002670|UniProtKB=Q5BH99	G-protein beta subunit [Source:UniProtKB/TrEMBLAcc:O74214]	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04393	Ras Pathway	P04563	Ets	HUMAN|HGNC=3488|UniProtKB=P14921	Protein C-ets-1	IDA	15699632	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00012	Cadherin signaling pathway	P00470	F-actin	CAEEL|WormBase=WBGene00000067|UniProtKB=O45815	ACTin	IC	10974003	PubMed	PTHR11937:SF352	ACTIN
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00007	Axon guidance mediated by semaphorins	P00333	RhoGEF	PANTR|Ensembl=ENSPTRG00000011039|UniProtKB=H2QGF2	Uncharacterized protein	ISS	12024019	PubMed	PTHR12673:SF122	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 1
P00052	TGF-beta signaling pathway	P01275	P38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00034	Integrin signalling pathway	P00933	Crk	CHICK|Ensembl=ENSGALG00000006390|UniProtKB=F1P241	Uncharacterized protein	ISS	8649368	PubMed	PTHR19969:SF9	CRK-LIKE PROTEIN
P00010	B cell activation	P00385	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	10540223	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	RAT|RGD=621060|UniProtKB=O88777	Presenilin-2	IDA	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00053	T cell activation	P01311	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01242	Casein kinase I	CHLRE|EnsemblGenome=CHLREDRAFT_15736|UniProtKB=Q8W1K7	Serine/threonine protein kinase	IDA	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	BACSU|EnsemblGenome=BSU21810|UniProtKB=P11045	Dihydrofolate reductase	ISS			PTHR22778:SF16	DIHYDROFOLATE REDUCTASE
P00057	Wnt signaling pathway	P01444	Wnt	CAEBR|Gene=CBG03476|UniProtKB=A8WV58	Protein CBR-EGL-20	ISS	11266476	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00029	Huntington disease	P00780	Microtubule	MOUSE|MGI=MGI=1920960|UniProtKB=Q9CWF2	Tubulin beta-2B chain	ISS	12932731	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00059	p53 pathway	G01572	NOXA	MACMU|Ensembl=ENSMMUG00000012622|UniProtKB=F7F0V0	Phorbol-12-myristate-13-acetate-induced protein 1	RCA			PTHR14299:SF0	PHORBOL-12-MYRISTATE-13-ACETATE-INDUCED PROTEIN 1
P00005	Angiogenesis	P00206	Wnt	RAT|RGD=1307015|UniProtKB=D3ZRW5	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	RAT|RGD=621005|UniProtKB=Q08849	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00034	Integrin signalling pathway	P00928	alpha actinin	HUMAN|HGNC=29804|UniProtKB=Q8N3F8	MICAL-like protein 1	IPI			PTHR44664:SF1	MICAL-LIKE PROTEIN 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IDA	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05913	Enkephalin release	P05972	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00047	PDGF signaling pathway	P01162	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02746	Heme biosynthesis	P02981	Glutamate-1-semialdehyde aminotransferase	SCHPO|PomBase=SPCC417.11c|UniProtKB=O94492	Uncharacterized aminotransferase C417.11c	ISS			PTHR43713:SF3	GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE
P00053	T cell activation	P01319	PAK	HUMAN|HGNC=8592|UniProtKB=O75914	Serine/threonine-protein kinase PAK 3	IDA	11259591	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00034	Integrin signalling pathway	P00906	Rap1	CHICK|Ensembl=ENSGALG00000001476|UniProtKB=F1NSA8	Uncharacterized protein	ISS	1904317	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00052	TGF-beta signaling pathway	P01275	P38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008018|UniProtKB=F7EPG4	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00005	Angiogenesis	P00238	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	IC	8457205	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MOUSE|MGI=MGI=101900|UniProtKB=P53690	Matrix metalloproteinase-14	TAS	12834808	PubMed	PTHR10201:SF24	MATRIX METALLOPROTEINASE-14
P00047	PDGF signaling pathway	P01162	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00019	Endothelin signaling pathway	P00591	PLCbeta	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	DROME|FlyBase=FBgn0005590|UniProtKB=P54631	Protein screw	IGI	http://flybase.org/reports/FBgn0005590.html	Website	PTHR11848:SF54	PROTEIN 60A-RELATED
P00006	Apoptosis signaling pathway	P00260	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04393	Ras Pathway	P04559	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	MOUSE|MGI=MGI=102522|UniProtKB=Q8R3Z5	Voltage-dependent L-type calcium channel subunit beta-1	IC	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	DANRE|ZFIN=ZDB-GENE-990415-223|UniProtKB=Q6NV44	Frizzled homolog 7a	TAS	8717036	PubMed	PTHR11309:SF31	FRIZZLED-7
P00053	T cell activation	P01322	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00562	p38	DROME|FlyBase=FBgn0015765|UniProtKB=O62618	Mitogen-activated protein kinase 14A	IGI	98079070	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00717	Phosphorylase b	MACMU|Ensembl=ENSMMUG00000014670|UniProtKB=F7ASP1	Alpha-1,4 glucan phosphorylase	ISS	4318782	PubMed	PTHR11468:SF12	GLYCOGEN PHOSPHORYLASE, LIVER FORM
P00018	EGF receptor signaling pathway	P00561	STAT	HUMAN|HGNC=11364|UniProtKB=P40763	Signal transducer and activator of transcription 3	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00006	Apoptosis signaling pathway	P00310	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00029	Huntington disease	P00807	Actin	XENTR|Xenbase=XB-GENE-480347|UniProtKB=Q6P640	Actin, alpha cardiac muscle 1	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P02729	Ascorbate degradation	P02852	L-xylulose-5-phosphate-3-epimerase	RAT|RGD=1564890|UniProtKB=A0A0G2JW38	Ribulose-phosphate 3-epimerase	ISS			PTHR11749:SF3	RIBULOSE-PHOSPHATE 3-EPIMERASE
P00020	FAS signaling pathway	P00615	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05915	Opioid proenkephalin pathway	P05994	G-protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00059	p53 pathway	P04633	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	ORYSJ|EnsemblGenome=OS05G0491100|UniProtKB=Q6F332	Calmodulin-2	ISS			PTHR23050:SF324	CALMODULIN-2-RELATED
P00049	Parkinson disease	P01208	Hsp70	CANLF|Ensembl=ENSCAFG00000016031|UniProtKB=E2QX84	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF216	HEAT SHOCK-RELATED 70 KDA PROTEIN 2
P06664	Gonadotropin-releasing hormone receptor pathway	P06779	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	RCA	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P06211	BMP/activin signaling pathway-drosophila	P06256	Full-length  BMP orthologous ligand	DROME|FlyBase=FBgn0000490|UniProtKB=P07713	Protein decapentaplegic	RCA	9759503	PubMed	PTHR11848:SF234	PROTEIN DECAPENTAPLEGIC
P00038	JAK/STAT signaling pathway	P01031	PIAS	CHICK|Ensembl=ENSGALG00000007970|UniProtKB=F1NSG6	Uncharacterized protein	ISS	8682149	PubMed	PTHR10782:SF11	E3 SUMO-PROTEIN LIGASE PIAS1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	RAT|RGD=2343|UniProtKB=P08483	Muscarinic acetylcholine receptor M3	ISS	12915051	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00006	Apoptosis signaling pathway	P00297	NFkappaB	PANTR|Ensembl=ENSPTRG00000011949|UniProtKB=H2QHY2	Uncharacterized protein	ISS			PTHR24169:SF4	PROTO-ONCOGENE C-REL
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IDA	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00021	FGF signaling pathway	P00642	MEK1-2	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00057	Wnt signaling pathway	P01443	Phospholipase C	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00005	Angiogenesis	P00193	SOS-1	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00023	General transcription regulation	P00658	TBP-associated factors	MACMU|Ensembl=ENSMMUG00000005748|UniProtKB=F6TWH6	Transcription initiation factor TFIID subunit 12	ISS			PTHR12264:SF21	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12
P06664	Gonadotropin-releasing hormone receptor pathway	P06779	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	RCA	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01227	20S proteasome	SCHPO|PomBase=SPBC577.10|UniProtKB=Q9USQ9	Probable proteasome subunit beta type-7	TAS	12859888	PubMed	PTHR11599:SF5	PROTEASOME SUBUNIT BETA TYPE-4
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02726	Aminobutyrate degradation	P02825	4-aminobutyrate aminotransferase	BOVIN|Gene=ABAT|UniProtKB=Q9BGI0	4-aminobutyrate aminotransferase, mitochondrial	ISS	8133261	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00047	PDGF signaling pathway	P01159	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P02740	De novo pyrimidine ribonucleotides biosythesis	P02927	Dihydrooratate oxidase	HUMAN|HGNC=2867|UniProtKB=Q02127	Dihydroorotate dehydrogenase (quinone), mitochondrial	ISS			PTHR43517:SF1	DIHYDROOROTATE DEHYDROGENASE  QUINONE , MITOCHONDRIAL
P00001	Adrenaline and noradrenaline biosynthesis	P00066	DOPA decarb.	DROME|FlyBase=FBgn0000422|UniProtKB=P05031	Aromatic-L-amino-acid decarboxylase	ISS	90339966	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P02771	Pyrimidine Metabolism	P03128	Dihydrouracil Dehydrogenase	MOUSE|MGI=MGI=2139667|UniProtKB=Q8CHR6	Dihydropyrimidine dehydrogenase [NADP(+)]	ISS	1512248	PubMed	PTHR43073:SF2	DIHYDROPYRIMIDINE DEHYDROGENASE  NADP +
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00034	Integrin signalling pathway	P00948	Rho	XENTR|Xenbase=XB-GENE-489222|UniProtKB=Q28GJ8	Ras homolog gene family, member A	ISS	10556059	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00054	Toll receptor signaling pathway	P01369	MKK1	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00006	Apoptosis signaling pathway	P00318	PKCs	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00054	Toll receptor signaling pathway	P01341	Elk1	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	ISS	11050086	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00047	PDGF signaling pathway	P01173	STAT	MONDO|Ensembl=ENSMODG00000014836|UniProtKB=F7D2D3	Signal transducer and activator of transcription	ISS	10835485	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00047	PDGF signaling pathway	P01161	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00807	Actin	STRPU|EnsemblGenome=SPU_026078|UniProtKB=W4ZD41	Uncharacterized protein	IDA	14684598	PubMed	PTHR11937:SF277	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00226	Delta/Serrate	PANTR|Ensembl=ENSPTRG00000010975|UniProtKB=H2QGB2	Uncharacterized protein	ISS	10742114	PubMed	PTHR24044:SF308	DELTA-LIKE PROTEIN 3
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	MOUSE|MGI=MGI=109284|UniProtKB=Q61144	Presenilin-2	TAS	12885769	PubMed	PTHR10202:SF13	PRESENILIN-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CHICK|Ensembl=ENSGALG00000006540|UniProtKB=F1NW19	Uncharacterized protein	IDA			PTHR43893:SF13	SUBFAMILY NOT NAMED
P00010	B cell activation	P00371	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00402	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00543	ERK1-2	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IGI	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01227	20S proteasome	RAT|RGD=61848|UniProtKB=P34064	Proteasome subunit alpha type-5	ISS	12859888	PubMed	PTHR11599:SF14	PROTEASOME SUBUNIT ALPHA TYPE-5
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	BOVIN|Gene=ARPC5|UniProtKB=Q3SYX9	Actin-related protein 2/3 complex subunit 5	ISS	12932731	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=17175|UniProtKB=Q9P212	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	TAS			PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00053	T cell activation	P01305	Calmodulin	BRAFL|Gene=BRAFLDRAFT_124869|UniProtKB=C3ZEW0	Putative uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF263	SUBFAMILY NOT NAMED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DANRE|ZFIN=ZDB-GENE-041001-104|UniProtKB=Q5TZD4	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00025	Hedgehog signaling pathway	P00682	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00907	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01457	GBeta	SCLS1|EnsemblGenome=SS1G_03482|UniProtKB=A7EDU2	Guanine nucleotide-binding protein beta subunit	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	RCA	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	IDA	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00048	PI3 kinase pathway	P01185	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00018	EGF receptor signaling pathway	P00552	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00021	FGF signaling pathway	P00645	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	20010089	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=98961|UniProtKB=P24383	Protein Wnt-7a	TAS	12549854	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00036	Interleukin signaling pathway	P00981	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00005	Angiogenesis	P00219	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05915	Opioid proenkephalin pathway	P05994	G-protein	BOVIN|Ensembl=ENSBTAG00000006495|UniProtKB=P11017	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PHYPA|Gene=PHYPADRAFT_107830|UniProtKB=A9TBG2	Actin 7	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00036	Interleukin signaling pathway	P00977	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	SCLS1|EnsemblGenome=SS1G_05445|UniProtKB=A7EJF2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00056	VEGF signaling pathway	P01415	MAPKAPK2/3	ANOGA|Gene=AgaP_AGAP011890|UniProtKB=Q7PZG1	AGAP011890-PA (Fragment)	ISS			PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00568	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IGI	15572354	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00206	Wnt	RAT|RGD=1597195|UniProtKB=D4A9J2	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00037	Ionotropic glutamate receptor pathway	P01026	KA	BOVIN|Ensembl=ENSBTAG00000011723|UniProtKB=E1BKL6	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MONDO|Ensembl=ENSMODG00000011628|UniProtKB=F6U132	Actin-related protein 2/3 complex subunit 3	ISS			PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00054	Toll receptor signaling pathway	P01369	MKK1	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=12781|UniProtKB=Q93097	Protein Wnt-2b	TAS	11266476	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02748	Isoleucine biosynthesis	P02998	Dihydroxyacid dehydratase	NEUCR|EnsemblGenome=EFNCRG00000005870|UniProtKB=Q1K658	Dihydroxy-acid dehydratase	ISS			PTHR21000:SF5	DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=619917|UniProtKB=F1MA46	Protein Pcdh12	ISS	8120095	PubMed	PTHR24028:SF42	PROTOCADHERIN-12
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05913	Enkephalin release	P05974	G-Protein (i)	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	CHICK|Ensembl=ENSGALG00000012617|UniProtKB=Q06900	Receptor protein serine/threonine kinase	TAS	10683140	PubMed	PTHR23255:SF61	TGF-BETA RECEPTOR TYPE-1
P00053	T cell activation	P01311	Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	IDA	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00049	Parkinson disease	P01238	14-3-3	MOUSE|MGI=MGI=109484|UniProtKB=P63101	14-3-3 protein zeta/delta	ISS	1499718	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CRYNJ|EnsemblGenome=CNA04650|UniProtKB=Q5KP06	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02738	De novo purine biosynthesis	P02905	Amidophosphoribosyl transferase	THEMA|EnsemblGenome=TM_1247|UniProtKB=Q9X0X4	Amidophosphoribosyltransferase	ISS			PTHR11907:SF0	AMIDOPHOSPHORIBOSYLTRANSFERASE
P00019	Endothelin signaling pathway	P00568	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IGI	10747026	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CHLRE|EnsemblGenome=CHLREDRAFT_193901|UniProtKB=Q9FXT7	Mitogen-activated protein kinase	ISS	11275338	gi	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IDA	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04395	Vasopressin synthesis	P04593	Glycopeptide	RAT|RGD=3238|UniProtKB=P01179	Oxytocin-neurophysin 1	IC	6717565	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00047	PDGF signaling pathway	P01142	p90RSK	BOVIN|Ensembl=ENSBTAG00000009175|UniProtKB=E1BLQ5	Uncharacterized protein	ISS	6755374	gi	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P06959	CCKR signaling map	P07084	MEN1	HUMAN|HGNC=7010|UniProtKB=O00255	Menin	RCA	14996729	PubMed	PTHR12693:SF3	MENIN
P00029	Huntington disease	P00807	Actin	CAEEL|WormBase=WBGene00000200|UniProtKB=P53489	Actin-related protein 2	IDA	11889126	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00021	FGF signaling pathway	P00646	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	IPI	8270251	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00049	Parkinson disease	P01219	SAPK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01154	Ras	CAEEL|WormBase=WBGene00002335|UniProtKB=P22981	Ras protein let-60	ISS	12024031	PubMed	PTHR24070:SF385	GTPASE HRAS
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00007	Axon guidance mediated by semaphorins	P00340	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00892	Grb2	CAEBR|Gene=CBG16856|UniProtKB=A8XPY6	Protein CBR-SEM-5	ISS	8307166	PubMed	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	176910	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MONDO|Ensembl=ENSMODG00000013079|UniProtKB=F7FB74	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00052	TGF-beta signaling pathway	P01276	Co-Smads	MONDO|Ensembl=ENSMODG00000010995|UniProtKB=F7A1M2	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00045	Notch signaling pathway	P01099	Notch	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00021	FGF signaling pathway	P00627	ERK1-2	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04397	p53 pathway by glucose deprivation	P04641	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	PHYIT|EnsemblGenome=PITG_06376|UniProtKB=D0N4Q3	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta, putative	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	ISS	15621031	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MOUSE|MGI=MGI=1928896|UniProtKB=Q9R0Q6	Actin-related protein 2/3 complex subunit 1A	ISS	12932731	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00059	p53 pathway	P01483	Mdm2	HUMAN|HGNC=6973|UniProtKB=Q00987	E3 ubiquitin-protein ligase Mdm2	IGI	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05918	p38 MAPK pathway	P06029	p38beta	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	RCA	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00004	Alzheimer disease-presenilin pathway	P00111	C99	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00046	Oxidative stress response	P01129	JNK1/2	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00056	VEGF signaling pathway	P01409	cPLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00010	B cell activation	P00388	PLC gamma2	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	IGI	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P05916	Opioid prodynorphin pathway	P06001	AC	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00053	T cell activation	P01306	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00014	Cholesterol biosynthesis	P00491	Hydroxymethyl glutaryl CoA reductase	BOVIN|Ensembl=ENSBTAG00000007840|UniProtKB=A7Z064	3-hydroxy-3-methylglutaryl-coenzyme A reductase	ISS	P09610	SPACC	PTHR10572:SF2	3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE
P05915	Opioid proenkephalin pathway	P05994	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	8170357	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	RAT|RGD=1309514|UniProtKB=D4AA42	Guanine nucleotide binding protein, alpha transducing 2 (Predicted), isoform CRA_b	ISS	12488551	PubMed	PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IDA	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00057	Wnt signaling pathway	P01438	PP2A	MACMU|Ensembl=ENSMMUG00000020819|UniProtKB=F7HSM1	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00260	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00034	Integrin signalling pathway	P00936	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00219	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IGI	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	RCA	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00047	PDGF signaling pathway	P01147	Nck	MONDO|Ensembl=ENSMODG00000002546|UniProtKB=F7ALW1	Uncharacterized protein	ISS	12874226	PubMed	PTHR44108:SF1	CYTOPLASMIC PROTEIN NCK2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	14744463	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P05913	Enkephalin release	P05972	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P02749	Leucine biosynthesis	P03001	3-Isopropylmalate dehydrogenase	ASHGO|EnsemblGenome=AGOS_AAL012C|UniProtKB=O60027	3-isopropylmalate dehydrogenase	ISS			PTHR42979:SF1	3-ISOPROPYLMALATE DEHYDROGENASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONBE|Gene=37852|UniProtKB=A9V489	Predicted protein	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DANRE|ZFIN=ZDB-GENE-040426-1354|UniProtKB=Q7T2C5	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00047	PDGF signaling pathway	P01162	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	PANTR|Ensembl=ENSPTRG00000008768|UniProtKB=H2QC98	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF368	MYOSIN-8
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	DANRE|ZFIN=ZDB-GENE-040426-1675|UniProtKB=Q6P971	Pyrroline-5-carboxylate reductase	ISS			PTHR11645:SF47	PYRROLINE-5-CARBOXYLATE REDUCTASE
P00057	Wnt signaling pathway	P01438	PP2A	TAKRU|Ensembl=ENSTRUG00000008018|UniProtKB=H2T5N4	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P02750	Lipoate_biosynthesis	P03003	Lipoyl-protein ligase	PYRAE|EnsemblGenome=PAE2651|UniProtKB=Q8ZUR4	Probable octanoyltransferase	ISS			PTHR10993:SF2	OCTANOYLTRANSFERASE
P05731	GABA-B receptor II signaling	P05754	Ggamma	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P02749	Leucine biosynthesis	P03002	Isopropylmalate isomerase	THEMA|EnsemblGenome=TM_0554|UniProtKB=Q9WZ24	3-isopropylmalate dehydratase large subunit 2	ISS			PTHR43822:SF2	HOMOACONITASE, MITOCHONDRIAL
P00010	B cell activation	P00383	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00011	Blood coagulation	P00422	FIXa	CANLF|Gene=F9|UniProtKB=P19540	Coagulation factor IX	ISS	14270099	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	YARLI|EnsemblGenome=YALI0_D08272g|UniProtKB=Q9UVF3	Actin	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	XENTR|Xenbase=XB-GENE-992519|UniProtKB=F6VS22	Uncharacterized protein	ISS			PTHR43893:SF8	D 1B  DOPAMINE RECEPTOR
P00034	Integrin signalling pathway	P00927	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00047	PDGF signaling pathway	P01173	STAT	RAT|RGD=3772|UniProtKB=P52631	Signal transducer and activator of transcription 3	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00006	Apoptosis signaling pathway	P00310	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	MOUSE|MGI=MGI=1351340|UniProtKB=Q9QYS2	Metabotropic glutamate receptor 3	ISS	12488551	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00048	PI3 kinase pathway	P01188	Gbetagamma	SCLS1|EnsemblGenome=SS1G_03482|UniProtKB=A7EDU2	Guanine nucleotide-binding protein beta subunit	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	XENTR|Xenbase=XB-GENE-6469705|UniProtKB=Q6P8G3	Actin, alpha sarcomeric/skeletal	ISS	11889139	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P05734	Synaptic vesicle trafficking	P05774	NSF	DROME|FlyBase=FBgn0000346|UniProtKB=P46461	Vesicle-fusing ATPase 1	TAS	11348590	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00018	EGF receptor signaling pathway	P00556	PLCgamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IGI	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00012	Cadherin signaling pathway	P00477	GSK3beta	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04393	Ras Pathway	P04570	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	BOVIN|Ensembl=ENSBTAG00000014614|UniProtKB=P62739	Actin, aortic smooth muscle	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	ARATH|TAIR=AT3G03940|UniProtKB=Q9SQR8	Protein kinase family protein	IDA	11437445	PubMed	PTHR11909:SF131	CASEIN KINASE-LIKE PROTEIN-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	IC	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	88241036	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00048	PI3 kinase pathway	P01192	p110	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01443	Phospholipase C	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00057	Wnt signaling pathway	P01455	Smad4	ORNAN|Ensembl=ENSOANG00000006538|UniProtKB=F6YA42	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MOUSE|MGI=MGI=107814|UniProtKB=A2AQ07	Tubulin beta-1 chain	ISS	12932731	PubMed	PTHR11588:SF112	TUBULIN BETA-1 CHAIN
P02727	Androgen/estrogene/progesterone biosynthesis	P02826	Estradiol 17beta-dehydrogenase	PANTR|Ensembl=ENSPTRG00000021150|UniProtKB=H2QXI5	Uncharacterized protein	ISS			PTHR43899:SF7	TESTOSTERONE 17-BETA-DEHYDROGENASE 3
P00057	Wnt signaling pathway	P01428	Frizzled	PANTR|Ensembl=ENSPTRG00000020122|UniProtKB=H2QVZ0	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF22	FRIZZLED-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01177	P110ACT	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	IDA	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04567	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	IDA	10799299	PubMed	PTHR10048:SF14	PI-3 KINASE
P00009	Axon guidance mediated by netrin	P00363	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00634	MEKK1-5	RAT|RGD=1311192|UniProtKB=A0A0G2K3R1	Protein Map3k4	ISS	97236778	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00047	PDGF signaling pathway	P01147	Nck	CANLF|Ensembl=ENSCAFG00000007451|UniProtKB=E2RHV6	Uncharacterized protein	ISS	12874226	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00034	Integrin signalling pathway	P00916	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	RAT|RGD=2906|UniProtKB=P35407	C-X-C chemokine receptor type 2	ISS	4504683	gi	PTHR10489:SF689	C-X-C CHEMOKINE RECEPTOR TYPE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=69424|UniProtKB=Q99P84	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	12860966	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00006	Apoptosis signaling pathway	P00303	c-Jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	RAT|RGD=3804|UniProtKB=P29101	Synaptotagmin-2	RCA	SYT2_RAT	SPACC	PTHR10024:SF223	SYNAPTOTAGMIN-2
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	PANTR|Ensembl=ENSPTRG00000017549|UniProtKB=H2QS18	Dopamine receptor D1	ISS	11248120	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00036	Interleukin signaling pathway	P00985	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	9094314	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01465	Ggamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00018	EGF receptor signaling pathway	P00547	PP2A	BOVIN|Ensembl=ENSBTAG00000000754|UniProtKB=A2VDZ0	Protein phosphatase 2, regulatory subunit B', alpha isoform	ISS	12110603	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	TAS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00034	Integrin signalling pathway	P00922	Collagen	RAT|RGD=71029|UniProtKB=P13941	Collagen alpha-1(III) chain	ISS	10778855	PubMed	PTHR24023:SF604	COLLAGEN ALPHA-1 III  CHAIN
P00019	Endothelin signaling pathway	P00584	Gs	MOUSE|MGI=MGI=95774|UniProtKB=Q8CGK7	Guanine nucleotide-binding protein G(olf) subunit alpha	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00050	Plasminogen activating cascade	P01249	pro-tPA	MOUSE|MGI=MGI=97610|UniProtKB=P11214	Tissue-type plasminogen activator	ISS	137121	gi	PTHR44617:SF1	TISSUE-TYPE PLASMINOGEN ACTIVATOR
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P05913	Enkephalin release	P05974	G-Protein (i)	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00025	Hedgehog signaling pathway	P00683	Slimb	HUMAN|HGNC=1144|UniProtKB=Q9Y297	F-box/WD repeat-containing protein 1A	ISS	10074433	PubMed	PTHR44038:SF2	F-BOX/WD REPEAT-CONTAINING PROTEIN 1A
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000012922|UniProtKB=H2QJF2	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00006	Apoptosis signaling pathway	P00260	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01212	p38 MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00006	Apoptosis signaling pathway	P00321	HSP70	SCHPO|PomBase=SPAC22A12.15c|UniProtKB=P36604	78 kDa glucose-regulated protein homolog	ISS	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00054	Toll receptor signaling pathway	P01339	TLR4	HUMAN|HGNC=11850|UniProtKB=O00206	Toll-like receptor 4	ISS			PTHR44568:SF1	TOLL-LIKE RECEPTOR 4
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01455	Smad4	MACMU|Ensembl=ENSMMUG00000018384|UniProtKB=F7GZL6	Mothers against decapentaplegic homolog	ISS	12736218	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P00046	Oxidative stress response	P01130	CHOP	CANLF|Ensembl=ENSCAFG00000030112|UniProtKB=J9P1A6	DNA damage-inducible transcript 3 protein	ISS	10207617	PubMed	PTHR16833:SF0	DNA DAMAGE-INDUCIBLE TRANSCRIPT 3 PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	IC	3487386	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	CANLF|Ensembl=ENSCAFG00000013324|UniProtKB=F1PCS0	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00048	PI3 kinase pathway	P01188	Gbetagamma	CANLF|Ensembl=ENSCAFG00000015662|UniProtKB=E2RHY4	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	CAEEL|WormBase=WBGene00001679|UniProtKB=P17343	Guanine nucleotide-binding protein subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00004	Alzheimer disease-presenilin pathway	P00148	Erb-B4 N-terminal fragment	HUMAN|HGNC=3432|UniProtKB=Q15303	Receptor tyrosine-protein kinase erbB-4	IDA	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00048	PI3 kinase pathway	P01192	p110	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00973	PKB	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00546	GAP	RAT|RGD=3168|UniProtKB=P97526	Neurofibromin	ISS	95047432	PubMed	PTHR10194:SF60	NEUROFIBROMIN
P02749	Leucine biosynthesis	P03000	Branched chain amino acid aminotransferase	CAEEL|WormBase=WBGene00012855|UniProtKB=Q9XXD8	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF28	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MACMU|Ensembl=ENSMMUG00000017431|UniProtKB=F7HPP3	Uncharacterized protein	ISS	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04398	p53 pathway feedback loops 2	P04651	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	RCA	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00005	Angiogenesis	P00223	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00019	Endothelin signaling pathway	P00572	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IGI	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00045	Notch signaling pathway	P01103	Next	HUMAN|HGNC=7883|UniProtKB=Q9UM47	Neurogenic locus notch homolog protein 3	IC	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IDA	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00049	Parkinson disease	P01227	20S proteasome	YEAST|SGD=S000003485|UniProtKB=P32379	Proteasome subunit alpha type-5	TAS	12859888	PubMed	PTHR11599:SF14	PROTEASOME SUBUNIT ALPHA TYPE-5
P00036	Interleukin signaling pathway	P00990	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01153	GSK3	YEAST|SGD=S000004747|UniProtKB=P38615	Serine/threonine-protein kinase RIM11/MSD1	ISS	7529201	PubMed	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P04393	Ras Pathway	P04553	PAK	XENTR|Xenbase=XB-GENE-961764|UniProtKB=F6W3Y0	Uncharacterized protein	ISS	7559398	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05730	Endogenous cannabinoid signaling	P05751	Galpha	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02779	Thiamin biosynthesis	P03175	1-Deoxyxylulose-5-phosphate synthase	FUSNN|EnsemblGenome=FN1464|UniProtKB=Q8R606	1-deoxy-D-xylulose-5-phosphate synthase	ISS			PTHR43322:SF1	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00983	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02777	Succinate to proprionate conversion	P03161	Methylmalonyl-CoA mutase	MYCTU|EnsemblGenome=Rv1492|UniProtKB=P9WJK7	Probable methylmalonyl-CoA mutase small subunit	ISS			PTHR43589:SF1	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01444	Wnt	RAT|RGD=621348|UniProtKB=Q9QXQ5	Protein Wnt-4	IDA	11266476	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00016	Cytoskeletal regulation by Rho GTPase	P00507	Rho	BOVIN|Ensembl=ENSBTAG00000017200|UniProtKB=A4FV20	RHOJ protein	ISS	12932731	PubMed	PTHR24072:SF17	RHO-RELATED GTP-BINDING PROTEIN RHOJ
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	BOVIN|Ensembl=ENSBTAG00000011723|UniProtKB=E1BKL6	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00034	Integrin signalling pathway	P00907	ERK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	ISS			PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	IGI	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	SCHPO|PomBase=SPAC1687.15|UniProtKB=Q10452	Protein kinase gsk3	IDA	7529201	PubMed	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00049	Parkinson disease	P01238	14-3-3	SCHMA|EnsemblGenome=Smp_009760|UniProtKB=G4LUI9	14-3-3 protein, putative	IDA	96123403	PubMed	PTHR18860:SF13	14-3-3 PROTEIN ZETA
P00018	EGF receptor signaling pathway	P00545	JNK1-3	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02774	Salvage pyrimidine deoxyribonucleotides	P03147	Thymidine kinase	LEIMA|EnsemblGenome=LmjF.21.1210|UniProtKB=Q4QC75	Thymidine kinase	ISS			PTHR11441:SF0	THYMIDINE KINASE, CYTOSOLIC
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	HUMAN|HGNC=132|UniProtKB=P60709	Actin, cytoplasmic 1	IC	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P05918	p38 MAPK pathway	P06032	MKK6	CANLF|Ensembl=ENSCAFG00000010758|UniProtKB=E2R7W7	Uncharacterized protein	ISS	8622669	PubMed	PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P04393	Ras Pathway	P04547	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P02753	Methionine biosynthesis	P03026	O-Succinyl homoserine lyase	ARATH|TAIR=AT3G01120|UniProtKB=P55217	Cystathionine gamma-synthase 1, chloroplastic	ISS			PTHR43379:SF1	CYSTATHIONINE GAMMA-SYNTHASE 1, CHLOROPLASTIC-RELATED
P00053	T cell activation	P01312	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	MONDO|Ensembl=ENSMODG00000014177|UniProtKB=F6U7A6	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01332	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	CAEEL|WormBase=WBGene00004769|UniProtKB=P52166	Presenilin sel-12	IDA	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	IDA	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00590	IP3 R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT4G36450|UniProtKB=O23236	Mitogen-activated protein kinase 14	IDA	10514528	PubMed	PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P02748	Isoleucine biosynthesis	P02997	Acetolactate synthase	BACSU|EnsemblGenome=BSU28310|UniProtKB=P37251	Acetolactate synthase large subunit	ISS			PTHR18968:SF116	ACETOLACTATE SYNTHASE ISOZYME 3 LARGE SUBUNIT
P00036	Interleukin signaling pathway	P00973	PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04375	5HT3 type receptor mediated signaling pathway	P04425	K+ channel	HUMAN|HGNC=6278|UniProtKB=O14649	Potassium channel subfamily K member 3	ISS	15282272	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00054	Toll receptor signaling pathway	P01358	ERK1	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05917	Opioid proopiomelanocortin pathway	P06008	ACTH	MOUSE|MGI=MGI=97742|UniProtKB=P01193	Pro-opiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00004	Alzheimer disease-presenilin pathway	P00137	Tip60	MOUSE|MGI=MGI=1932051|UniProtKB=Q8CHK4	Histone acetyltransferase KAT5	IDA	11441186	PubMed	PTHR10615:SF124	HISTONE ACETYLTRANSFERASE KAT5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	CANLF|Ensembl=ENSCAFG00000004090|UniProtKB=F1PNQ0	Uncharacterized protein	ISS	2255909	PubMed	PTHR11920:SF291	ADENYLATE CYCLASE TYPE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	PANTR|Ensembl=ENSPTRG00000013022|UniProtKB=H2QJL0	Uncharacterized protein	ISS	12441358	PubMed	PTHR24247:SF31	5-HYDROXYTRYPTAMINE RECEPTOR 2B
P00018	EGF receptor signaling pathway	P00547	PP2A	PANTR|Ensembl=ENSPTRG00000006426|UniProtKB=H2Q8F8	Protein phosphatase 2, regulatory subunit B', epsilon isoform	ISS	10092233	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00029	Huntington disease	P00807	Actin	DICDI|dictyBase=DDB_G0289489|UniProtKB=P07828	Actin-18	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	IC	11956331	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00016	Cytoskeletal regulation by Rho GTPase	P00519	ROCK	CANLF|Ensembl=ENSCAFG00000003549|UniProtKB=F1PE53	Uncharacterized protein	ISS			PTHR22988:SF28	RHO-ASSOCIATED PROTEIN KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	STRPU|EnsemblGenome=SPU_012282|UniProtKB=W4Y969	Uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF369	ACTIN-42A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CANLF|Ensembl=ENSCAFG00000005662|UniProtKB=E2R907	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=2136730|UniProtKB=Q91Y08	Protein Pcdhb1	IDA	8120095	PubMed	PTHR24028:SF12	PROTOCADHERIN BETA-1
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00029	Huntington disease	P00761	Truncated Htt	RAT|RGD=68337|UniProtKB=P51111	Huntingtin	TAS	8268927	PubMed	PTHR10170:SF10	HUNTINGTIN
P00019	Endothelin signaling pathway	P00586	Gq	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2520|UniProtKB=P61169	D(2) dopamine receptor	IDA	1319557	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00011	Blood coagulation	P00447	FVIIa	HUMAN|HGNC=3544|UniProtKB=P08709	Coagulation factor VII	ISS	11487022	PubMed	PTHR44064:SF1	COAGULATION FACTOR VII
P00034	Integrin signalling pathway	P00907	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00059	p53 pathway	G04689	Cyclin G	MONDO|Ensembl=ENSMODG00000007651|UniProtKB=F7FZG0	Uncharacterized protein	ISS	11983168	PubMed	PTHR10177:SF59	CYCLIN-G1
P00006	Apoptosis signaling pathway	P00270	Bcl-2	MACMU|Ensembl=ENSMMUG00000006577|UniProtKB=F7HPT9	Uncharacterized protein	ISS	2250705	PubMed	PTHR11256:SF11	APOPTOSIS REGULATOR BCL-2
P00005	Angiogenesis	P00211	GSK3beta	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	20331588	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00006	Apoptosis signaling pathway	P00270	Bcl-2	CHICK|Ensembl=ENSGALG00000012885|UniProtKB=Q00709	Apoptosis regulator Bcl-2	IDA	11323415	PubMed	PTHR11256:SF11	APOPTOSIS REGULATOR BCL-2
P00054	Toll receptor signaling pathway	P01355	AP1	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01472	Histone deacetylase	XENTR|Xenbase=XB-GENE-479583|UniProtKB=F6ULG8	Histone deacetylase	ISS	10485845	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04570	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01411	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00036	Interleukin signaling pathway	P00995	c-Myc	PANTR|Gene=MYC|UniProtKB=P23583	Myc proto-oncogene protein	ISS	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00053	T cell activation	P01300	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00185	JAK1	RAT|RGD=69056|UniProtKB=G3V9W2	Tyrosine-protein kinase	ISS	9637709	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00046	Oxidative stress response	P01133	Max	MACMU|Ensembl=ENSMMUG00000004341|UniProtKB=F6XM92	Protein max isoform a	ISS	11274345	PubMed	PTHR10328:SF3	PROTEIN MAX
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00053	T cell activation	P01300	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	BOVIN|Ensembl=ENSBTAG00000011803|UniProtKB=F1MTZ2	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF427	MYOSIN-3
P00010	B cell activation	P00371	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00054	Toll receptor signaling pathway	P01356	ERK2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00057	Wnt signaling pathway	P01446	Calcineurin	BOVIN|Ensembl=ENSBTAG00000016005|UniProtKB=P48452	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	IDA	12015605	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00010	B cell activation	P00386	Calcineurin	CHICK|Ensembl=ENSGALG00000005243|UniProtKB=E1C2T7	Serine/threonine-protein phosphatase	ISS	7532676	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01440	Cadherin	MONDO|Ensembl=ENSMODG00000004237|UniProtKB=F6UBJ7	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF99	CADHERIN-9
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	TAS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00034	Integrin signalling pathway	P00942	Fyn	RAT|RGD=2641|UniProtKB=Q62844	Tyrosine-protein kinase Fyn	IPI	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00018	EGF receptor signaling pathway	P00547	PP2A	TRYB2|Gene=Tb11.01.8740|UniProtKB=Q380Z0	Serine/threonine-protein phosphatase	ISS			PTHR11668:SF22	SERINE/THREONINE-PROTEIN PHOSPHATASE 4 CATALYTIC SUBUNIT
P00059	p53 pathway	G01572	NOXA	HUMAN|HGNC=21411|UniProtKB=Q9BRQ8	Apoptosis-inducing factor 2	IGI			PTHR43735:SF9	APOPTOSIS-INDUCING FACTOR 2
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MACMU|Ensembl=ENSMMUG00000011435|UniProtKB=F6VUD5	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF232	LEFT-RIGHT DETERMINATION FACTOR 2
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	ARATH|TAIR=AT4G35290|UniProtKB=Q93YT1	Glutamate receptor 3.2	ISS	12941441	PubMed	PTHR43891:SF18	GLUTAMATE RECEPTOR 3.1-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	MOUSE|MGI=MGI=106212|UniProtKB=Q8BMN3	Neuronal acetylcholine receptor subunit beta-3	ISS			PTHR18945:SF75	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	PANTR|Ensembl=ENSPTRG00000005197|UniProtKB=A5A6J7	Ras-related protein Rap-1b	ISS	1904317	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	ANOGA|EnsemblGenome=AGAP002578|UniProtKB=F5HKU8	AGAP002578-PB	ISS	14507926	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00010	B cell activation	P00371	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00010	B cell activation	P00384	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IDA	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00059	p53 pathway	G04694	p110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00021	FGF signaling pathway	P00625	MKK3,6	BOVIN|Ensembl=ENSBTAG00000010576|UniProtKB=A4IFH7	MAP2K3 protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00081	Pro-BACE-1	PANTR|Ensembl=ENSPTRG00000004324|UniProtKB=H2Q4U8	Beta-site APP-cleaving enzyme 1	ISS	10531052	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00047	PDGF signaling pathway	P01150	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00006	Apoptosis signaling pathway	P00302	ATF	CANLF|Ensembl=ENSCAFG00000013332|UniProtKB=F1PCQ4	Uncharacterized protein	ISS	11390664	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00018	EGF receptor signaling pathway	P00560	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	RAT|RGD=62004|UniProtKB=Q62915	Peripheral plasma membrane protein CASK	ISS	11679592	PubMed	PTHR23122:SF40	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P00029	Huntington disease	G01533	Bax	BOVIN|Ensembl=ENSBTAG00000013340|UniProtKB=O02703	Apoptosis regulator BAX	ISS	11099028	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P00036	Interleukin signaling pathway	P00981	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05731	GABA-B receptor II signaling	P05755	Gbeta	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05918	p38 MAPK pathway	P06020	p38delta	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00006	Apoptosis signaling pathway	P00302	ATF	HUMAN|HGNC=786|UniProtKB=P18848	Cyclic AMP-dependent transcription factor ATF-4	ISS	11390664	PubMed	PTHR13044:SF2	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	HUMAN|HGNC=13735|UniProtKB=P49795	Regulator of G-protein signaling 19	ISS	8756726	PubMed	PTHR10845:SF145	REGULATOR OF G-PROTEIN SIGNALING 19
P05734	Synaptic vesicle trafficking	P05778	SNAP-25	RAT|RGD=3728|UniProtKB=P60881	Synaptosomal-associated protein 25	RCA			PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	RAT|RGD=71027|UniProtKB=P42264	Glutamate receptor ionotropic, kainate 3	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	MACMU|Ensembl=ENSMMUG00000014498|UniProtKB=F7GEI8	Uncharacterized protein	ISS	14624853	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P06664	Gonadotropin-releasing hormone receptor pathway	P06699	AC	MOUSE|MGI=MGI=99677|UniProtKB=O88444	Adenylate cyclase type 1	RCA	2491850	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00057	Wnt signaling pathway	P01428	Frizzled	HUMAN|HGNC=4047|UniProtKB=O00144	Frizzled-9	IDA	8717036	PubMed	PTHR11309:SF79	FRIZZLED-9
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DROME|FlyBase=FBgn0011743|UniProtKB=P45891	Actin-like protein 53D	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00021	FGF signaling pathway	P00640	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04570	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04384	Gamma-aminobutyric acid synthesis	P04482	Glutamate decarboxylase	MOUSE|MGI=MGI=95634|UniProtKB=P48320	Glutamate decarboxylase 2	ISS	2247446	PubMed	PTHR11999:SF77	GLUTAMATE DECARBOXYLASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P02757	O-antigen biosynthesis	P03045	dTDP-glucose 4,6-dehydratase	MONDO|Ensembl=ENSMODG00000009373|UniProtKB=F7CQ20	Uncharacterized protein	ISS			PTHR43000:SF7	DTDP-D-GLUCOSE 4,6-DEHYDRATASE
P00049	Parkinson disease	P01227	20S proteasome	PHYPA|Gene=PHYPADRAFT_183899|UniProtKB=A9SDV6	Proteasome subunit alpha type	TAS	12859888	PubMed	PTHR11599:SF14	PROTEASOME SUBUNIT ALPHA TYPE-5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01070	K+ channel	RAT|RGD=621504|UniProtKB=O88943	Potassium voltage-gated channel subfamily KQT member 2	ISS	12165472	PubMed	PTHR11537:SF6	POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 2
P04393	Ras Pathway	P04559	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	8649368	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06768	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	RCA	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	PANTR|Ensembl=ENSPTRG00000004326|UniProtKB=H2Q4V0	Uncharacterized protein	ISS			PTHR44107:SF3	DOWN SYNDROME CELL ADHESION MOLECULE-LIKE PROTEIN 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	CHICK|Ensembl=ENSGALG00000009368|UniProtKB=F1P0K9	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF27	REGULATOR OF G-PROTEIN SIGNALING 6
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	12810719	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	AQUAE|EnsemblGenome=aq_094|UniProtKB=O66503	Ribonucleoside-diphosphate reductase subunit alpha	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00036	Interleukin signaling pathway	P00973	PKB	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00015	Circadian clock system	P00502	Casein kinase I	XENTR|Xenbase=XB-GENE-481480|UniProtKB=Q5XGI6	Casein kinase 1, epsilon	ISS	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00010	B cell activation	P00388	PLC gamma2	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00053	T cell activation	P01312	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05913	Enkephalin release	P05974	G-Protein (i)	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	IC	10704417	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00047	PDGF signaling pathway	P01164	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	15531926	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00029	Huntington disease	P00774	Dynein complex	PANTR|Ensembl=ENSPTRG00000006735|UniProtKB=H2R961	Uncharacterized protein	ISS	9454836	PubMed	PTHR10676:SF314	CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00010	B cell activation	P00373	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01149	MNK1/2	HUMAN|HGNC=7111|UniProtKB=Q9HBH9	MAP kinase-interacting serine/threonine-protein kinase 2	ISS	9155017	PubMed	PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	RCA	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IDA	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00037	Ionotropic glutamate receptor pathway	P01005	NR2D	HUMAN|HGNC=4588|UniProtKB=O15399	Glutamate receptor ionotropic, NMDA 2D	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	PANTR|Ensembl=ENSPTRG00000014365|UniProtKB=H2R0C8	Casein kinase 1, epsilon	ISS	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00019	Endothelin signaling pathway	P00591	PLCbeta	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IGI	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	ANOGA|EnsemblGenome=AGAP005912|UniProtKB=Q7Q6D3	AGAP005912-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04379	Beta3 adrenergic receptor signaling pathway	P04449	Beta3	MACMU|Ensembl=ENSMMUG00000005876|UniProtKB=Q28524	Beta-3 adrenergic receptor	ISS	11943840	PubMed	PTHR24248:SF3	BETA-3 ADRENERGIC RECEPTOR
P00034	Integrin signalling pathway	P00944	Actin	CAEEL|WormBase=WBGene00000067|UniProtKB=O45815	ACTin	ISS	14684598	PubMed	PTHR11937:SF352	ACTIN
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	NEUCR|EnsemblGenome=EFNCRG00000000159|UniProtKB=F5HH30	Guanine nucleotide-binding protein beta subunit	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IDA	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00029	Huntington disease	P00790	beta-Tubulin	TRYB2|Gene=TB927.1.2330|UniProtKB=Q4GYY6	Beta tubulin	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00057	Wnt signaling pathway	P01456	beta-arrestin	RAT|RGD=3619|UniProtKB=P15887	S-arrestin	IC	10206946	PubMed	PTHR11792:SF15	S-ARRESTIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000003236|UniProtKB=F7DNS6	Uncharacterized protein	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	BOVIN|Ensembl=ENSBTAG00000005464|UniProtKB=E1B9K3	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	RCA			PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00187	beta catenin	XENTR|Xenbase=XB-GENE-487200|UniProtKB=Q28GC2	Catenin (Cadherin associated protein), beta 1, 88kDa	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00018	EGF receptor signaling pathway	P00552	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00019	Endothelin signaling pathway	P00591	PLCbeta	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IGI	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00025	Hedgehog signaling pathway	P00691	CBP	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00053	T cell activation	P01300	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	XENTR|Xenbase=XB-GENE-490756|UniProtKB=F7BXC9	Uncharacterized protein (Fragment)	ISS	12145413	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00034	Integrin signalling pathway	P00940	Src	CHICK|Ensembl=ENSGALG00000003855|UniProtKB=P00523	Proto-oncogene tyrosine-protein kinase Src	IPI	11078745	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P05916	Opioid prodynorphin pathway	P06002	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02747	Histidine biosynthesis	P02987	ATP phosphoribosyl transferase	ARATH|TAIR=AT1G09795|UniProtKB=Q8GSJ1	ATP phosphoribosyltransferase 2, chloroplastic	ISS			PTHR21403:SF6	ATP PHOSPHORIBOSYLTRANSFERASE 1, CHLOROPLASTIC-RELATED
P00010	B cell activation	P00397	IKK	MACMU|Ensembl=ENSMMUG00000008351|UniProtKB=F7HRV5	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00034	Integrin signalling pathway	P00925	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00048	PI3 kinase pathway	G01546	Cyclin d	DANRE|ZFIN=ZDB-GENE-980526-176|UniProtKB=Q90459	G1/S-specific cyclin-D1	ISS	12356903	PubMed	PTHR10177:SF67	G1/S-SPECIFIC CYCLIN-D1
P04395	Vasopressin synthesis	P04593	Glycopeptide	PANTR|Ensembl=ENSPTRG00000013189|UniProtKB=H2QJV1	Uncharacterized protein	ISS	9756087	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	CAEEL|WormBase=WBGene00004958|UniProtKB=Q01608	Presenilin spe-4	TAS	12834808	PubMed	PTHR10202:SF17	PRESENILIN SPE-4
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01453	Ebi	TAKRU|Ensembl=ENSTRUG00000013251|UniProtKB=H2U9W1	Uncharacterized protein	ISS	11389839	PubMed	PTHR22846:SF40	F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN TBL1XR1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	XENTR|Xenbase=XB-GENE-493937|UniProtKB=Q5M8T9	Actin, alpha 2, smooth muscle, aorta	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00048	PI3 kinase pathway	P01178	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8235613	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	12972619	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00034	Integrin signalling pathway	P00931	Integrin beta	CHICK|Ensembl=ENSGALG00000000379|UniProtKB=Q92071	Integrin beta	IDA	3487386	PubMed	PTHR10082:SF25	INTEGRIN BETA-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CAEEL|WormBase=WBGene00002035|UniProtKB=Q19901	Heavy chain, Unconventional Myosin	IC			PTHR13140:SF663	HEAVY CHAIN, UNCONVENTIONAL MYOSIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	IC	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=98953|UniProtKB=P04426	Proto-oncogene Wnt-1	IDA	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MONDO|Ensembl=ENSMODG00000023470|UniProtKB=F6T6U1	Uncharacterized protein	ISS	11701344	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P00036	Interleukin signaling pathway	P00996	STAT	CANLF|Ensembl=ENSCAFG00000015346|UniProtKB=E2RE22	Signal transducer and activator of transcription	ISS	10835485	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	BOVIN|Ensembl=ENSBTAG00000013298|UniProtKB=A4IFJ5	Cytosolic phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00006	Apoptosis signaling pathway	P00314	MKK3	MACMU|Ensembl=ENSMMUG00000010904|UniProtKB=F7GLY5	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	RCA			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	RCA			PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000000760|UniProtKB=E2R9L4	Uncharacterized protein	ISS			PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00018	EGF receptor signaling pathway	P00562	p38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IGI	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00029	Huntington disease	P00796	Kainate receptor	HUMAN|HGNC=4582|UniProtKB=Q16099	Glutamate receptor ionotropic, kainate 4	IDA	12941441	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00056	VEGF signaling pathway	P01409	cPLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00012	Cadherin signaling pathway	P00475	Frizzled	XENTR|Xenbase=XB-GENE-483731|UniProtKB=Q5BL72	Frizzled-7	ISS	8717036	PubMed	PTHR11309:SF31	FRIZZLED-7
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IDA	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04397	p53 pathway by glucose deprivation	P04641	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05913	Enkephalin release	P05977	G-Protein (s)	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00048	PI3 kinase pathway	P01177	P110ACT	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9406|UniProtKB=Q16513	Serine/threonine-protein kinase N2	TAS	125549	gi	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00034	Integrin signalling pathway	P00926	GRAF	HUMAN|HGNC=17073|UniProtKB=Q9UNA1	Rho GTPase-activating protein 26	IPI	8649427	PubMed	PTHR12552:SF4	RHO GTPASE-ACTIVATING PROTEIN 26
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00048	PI3 kinase pathway	P01188	Gbetagamma	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000017374|UniProtKB=F7H6T7	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00006	Apoptosis signaling pathway	P00274	JNK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00034	Integrin signalling pathway	P00906	Rap1	XENTR|Xenbase=XB-GENE-479036|UniProtKB=Q640R7	Ras-related protein Rap-1b	ISS	10476970	PubMed	PTHR24070:SF382	RAS-RELATED PROTEIN RAP-1B
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00053	T cell activation	P01305	Calmodulin	CHICK|Gene_ORFName=RCJMB04_24e7|UniProtKB=P62149	Calmodulin	ISS	7514101	PubMed	PTHR23050:SF311	CALMODULIN
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02775	Salvage pyrimidine ribonucleotides	P03155	Cytosine deaminase	SCHPO|PomBase=SPBC16D10.10|UniProtKB=O94642	tRNA-specific adenosine deaminase subunit tad2	ISS			PTHR11079:SF92	TRNA-SPECIFIC ADENOSINE DEAMINASE 2
P00029	Huntington disease	P00778	NMDA receptor	MOUSE|MGI=MGI=95822|UniProtKB=Q01098	Glutamate receptor ionotropic, NMDA 2C	IDA	11554549	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DANRE|ZFIN=ZDB-GENE-040426-1178|UniProtKB=Q7SY24	Protein kinase C beta type	ISS	11880265	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00624	14-3-3	DANRE|ZFIN=ZDB-GENE-030131-779|UniProtKB=Q7ZW20	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1	ISS	5803225	gi	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00030	Hypoxia response via HIF activation	P00825	Thioredoxin	MACMU|Gene=TXN|UniProtKB=P29451	Thioredoxin	ISS	12115731	PubMed	PTHR10438:SF18	THIOREDOXIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	ANOGA|EnsemblGenome=AGAP002440|UniProtKB=Q17031	Cdc42 homolog	ISS			PTHR24072:SF192	CDC42 HOMOLOG
P00037	Ionotropic glutamate receptor pathway	P01026	KA	RAT|RGD=2734|UniProtKB=Q01812	Glutamate receptor ionotropic, kainate 4	ISS	12941441	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	XENTR|Xenbase=XB-GENE-5919679|UniProtKB=F6WET9	Uncharacterized protein	ISS			PTHR43893:SF11	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	CANLF|Ensembl=ENSCAFG00000004882|UniProtKB=F1PAE3	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00034	Integrin signalling pathway	P00912	Arp2/3	MONDO|Ensembl=ENSMODG00000011628|UniProtKB=F6U132	Actin-related protein 2/3 complex subunit 3	ISS	12473693	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P04396	Vitamin D metabolism and pathway	P04600	DBP	MOUSE|MGI=MGI=95669|UniProtKB=P21614	Vitamin D-binding protein	IPI	11799400	PubMed	PTHR11385:SF11	VITAMIN D-BINDING PROTEIN
P00034	Integrin signalling pathway	P00923	Arf1	DANRE|ZFIN=ZDB-GENE-040122-4|UniProtKB=Q6NYD8	ADP-ribosylation factor 2	ISS	12932731	PubMed	PTHR11711:SF299	ADP-RIBOSYLATION FACTOR 2
P04393	Ras Pathway	P04542	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	CHICK|Ensembl=ENSGALG00000001569|UniProtKB=Q9PSX7	Rho-related GTP-binding protein RhoC	ISS	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=11332|UniProtKB=P32745	Somatostatin receptor type 3	IDA	12562507	PubMed	PTHR24229:SF42	SOMATOSTATIN RECEPTOR TYPE 3
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P02747	Histidine biosynthesis	P02991	Histidinephosphate aminotransferase	PSEAE|EnsemblGenome=PA2531|UniProtKB=Q9I0V2	Probable aminotransferase	ISS			PTHR42885:SF2	HISTIDINOL-PHOSPHATE AMINOTRANSFERASE
P05730	Endogenous cannabinoid signaling	P05748	mGluR	MOUSE|MGI=MGI=1351338|UniProtKB=P97772	Metabotropic glutamate receptor 1	ISS	12351712	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000024992|UniProtKB=F6TUR3	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00047	PDGF signaling pathway	P01160	IP3 receptor	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00030	Hypoxia response via HIF activation	P00819	AKT	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	IC	9716402	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00006	Apoptosis signaling pathway	P00309	Smac/Diablo	MOUSE|MGI=MGI=1913843|UniProtKB=Q9JIQ3	Diablo homolog, mitochondrial	ISS			PTHR32247:SF3	DIABLO HOMOLOG, MITOCHONDRIAL
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000001067|UniProtKB=E1BAB4	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	HUMAN|HGNC=11510|UniProtKB=Q8N9I0	Synaptotagmin-2	TAS	600104	OMIM	PTHR10024:SF223	SYNAPTOTAGMIN-2
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	BOVIN|Ensembl=ENSBTAG00000003054|UniProtKB=F1MC23	Tyrosine-protein kinase receptor	ISS	12644000	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00049	Parkinson disease	P01238	14-3-3	PANTR|Ensembl=ENSPTRG00000019320|UniProtKB=H2QUT2	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	ISS	10407019	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00021	FGF signaling pathway	P00627	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00029	Huntington disease	P00780	Microtubule	PANTR|Ensembl=ENSPTRG00000009878|UniProtKB=H2QEA0	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	9332390	PubMed	PTHR10202:SF13	PRESENILIN-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00057	Wnt signaling pathway	P01437	TCF	PANTR|Ensembl=ENSPTRG00000012128|UniProtKB=H2QI87	Uncharacterized protein	ISS	12356903	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00021	FGF signaling pathway	P00633	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	87226391	PubMed	PTHR24070:SF385	GTPASE HRAS
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8682|UniProtKB=Q9Y5F2	Protocadherin beta-11	IDA	8120095	PubMed	PTHR24028:SF91	PROTOCADHERIN BETA-11
P00053	T cell activation	P01307	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00036	Interleukin signaling pathway	P00996	STAT	MONDO|Ensembl=ENSMODG00000014836|UniProtKB=F7D2D3	Signal transducer and activator of transcription	ISS	10835485	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MACMU|Ensembl=ENSMMUG00000006912|UniProtKB=F7EZ48	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF86	FRIZZLED-10
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	DICDI|dictyBase=DDB_G0279911|UniProtKB=P34093	Nucleoside diphosphate kinase, mitochondrial	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00006	Apoptosis signaling pathway	P00324	NIK	MOUSE|MGI=MGI=1858204|UniProtKB=Q9WUL6	Mitogen-activated protein kinase kinase kinase 14	ISS			PTHR24361:SF226	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 14
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	IDA	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CAEBR|Gene=CBG05858|UniProtKB=A8X1H0	Protein CBR-EGL-19 (Fragment)	ISS	15621031	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00552	Ras	DICPU|Gene=DICPUDRAFT_47179|UniProtKB=F0ZI47	Putative uncharacterized protein rasB	ISS	93205383	PubMed	PTHR24070:SF206	RAS-LIKE PROTEIN RASB
P00047	PDGF signaling pathway	P01175	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	7798194	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	HUMAN|HGNC=4616|UniProtKB=P49840	Glycogen synthase kinase-3 alpha	TAS	183955	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01284	JNK	CAEEL|WormBase=WBGene00013091|UniProtKB=Q9XXC0	Uncharacterized protein	TAS			PTHR24055:SF253	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00223	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00238	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00018	EGF receptor signaling pathway	P00560	Raf-1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IGI	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	HUMAN|HGNC=143|UniProtKB=P68032	Actin, alpha cardiac muscle 1	IDA	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00010	B cell activation	P00376	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00839	SHIP	CANLF|Ensembl=ENSCAFG00000005743|UniProtKB=F1PNY0	Uncharacterized protein	ISS	10610720	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00049	Parkinson disease	P01230	Src kinase	CANLF|Ensembl=ENSCAFG00000008755|UniProtKB=E2RSH8	Tyrosine-protein kinase	ISS	8054685	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P02772	Pyruvate metabolism	P03141	Citrate Synthetase	MOUSE|MGI=MGI=88529|UniProtKB=Q9CZU6	Citrate synthase, mitochondrial	TAS	2337600	PubMed	PTHR11739:SF8	CITRATE SYNTHASE, MITOCHONDRIAL
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00005	Angiogenesis	P00221	JNK1	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00046	Oxidative stress response	P01129	JNK1/2	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00779	TBP	SCHPO|PomBase=SPAC29E6.08|UniProtKB=P17871	TATA-box-binding protein	IPI	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00060	Ubiquitin proteasome pathway	P01492	E1	SCHPO|PomBase=SPAC4C5.04|UniProtKB=P79064	DNA damage tolerance protein rad31	ISS			PTHR10953:SF162	SUMO-ACTIVATING ENZYME SUBUNIT 1
P05915	Opioid proenkephalin pathway	P05988	peptide E	MACMU|Ensembl=ENSMMUG00000006775|UniProtKB=F7H3N8	Uncharacterized protein	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00010	B cell activation	P00391	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00060	Ubiquitin proteasome pathway	P01492	E1	PANTR|Ensembl=ENSPTRG00000010818|UniProtKB=H2QG08	Ubiquitin-like modifier activating enzyme 2	ISS			PTHR10953:SF5	SUMO-ACTIVATING ENZYME SUBUNIT 2
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	RCA	188830	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00761	Truncated Htt	CANLF|Ensembl=ENSCAFG00000014682|UniProtKB=F1P7Y7	Uncharacterized protein	ISS	9462744	PubMed	PTHR10170:SF10	HUNTINGTIN
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01211	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00047	PDGF signaling pathway	P01160	IP3 receptor	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00056	VEGF signaling pathway	P01411	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MOUSE|MGI=MGI=98727|UniProtKB=P17125	Transforming growth factor beta-3	TAS	9759503	PubMed	PTHR11848:SF34	TRANSFORMING GROWTH FACTOR BETA-3
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IGI	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00045	Notch signaling pathway	G01541	E(spl)-C genes	DROME|FlyBase=FBgn0000591|UniProtKB=P13098	Enhancer of split m8 protein	TAS	14973298	PubMed	PTHR10985:SF12	ENHANCER OF SPLIT M3 PROTEIN-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01411	Ras	BOVIN|Ensembl=ENSBTAG00000009778|UniProtKB=E1BMX0	Uncharacterized protein	ISS	9869449	PubMed	PTHR24070:SF186	GTPASE KRAS
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	XENTR|Xenbase=XB-GENE-480239|UniProtKB=F6V1C3	Uncharacterized protein	ISS			PTHR11454:SF4	INSULIN-LIKE GROWTH FACTOR I
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01409	cPLA2	MACMU|Ensembl=ENSMMUG00000021423|UniProtKB=F7EEZ1	Phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00018	EGF receptor signaling pathway	P00552	Ras	TAKRU|Ensembl=ENSTRUG00000017384|UniProtKB=H2V5P7	Uncharacterized protein	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MOUSE|MGI=MGI=102522|UniProtKB=Q8R3Z5	Voltage-dependent L-type calcium channel subunit beta-1	IDA	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00046	Oxidative stress response	P01138	MKK4	MONDO|Ensembl=ENSMODG00000008266|UniProtKB=F6Z879	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06812	L-type Ca2+	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	RCA	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00011	Blood coagulation	P00460	FXI	MACMU|Ensembl=ENSMMUG00000020064|UniProtKB=F7GHR4	Uncharacterized protein	ISS	14270099	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P00048	PI3 kinase pathway	P01199	Galpha	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	IC	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00919	Arf6	MACMU|Ensembl=ENSMMUG00000015642|UniProtKB=F6RLV0	ADP-ribosylation factor 6	ISS	12932731	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00021	FGF signaling pathway	P00648	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IGI	7492337	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00029	Huntington disease	P00797	p53	MOUSE|MGI=MGI=1330810|UniProtKB=O88898	Tumor protein 63	TAS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	MONDO|Ensembl=ENSMODG00000000537|UniProtKB=F6XN03	Uncharacterized protein	ISS	11055438	PubMed	PTHR10117:SF7	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 6
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04380	Cortocotropin releasing factor receptor signaling pathway	G04671	proopiomelanocortin	MACMU|Ensembl=ENSMMUG00000016463|UniProtKB=F7GBI0	Uncharacterized protein	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00059	p53 pathway	G04694	p110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DANRE|ZFIN=ZDB-GENE-040426-1354|UniProtKB=Q7T2C5	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00048	PI3 kinase pathway	P01204	GPCR	RAT|RGD=3434|UniProtKB=P70597	Prostaglandin E2 receptor EP1 subtype	IC	14607241	PubMed	PTHR11866:SF3	PROSTAGLANDIN E2 RECEPTOR EP1 SUBTYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00029	Huntington disease	P00790	beta-Tubulin	MONDO|Ensembl=ENSMODG00000003363|UniProtKB=F7CB79	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00021	FGF signaling pathway	P00645	Rac	DROME|FlyBase=FBgn0014011|UniProtKB=P48554	Ras-related protein Rac2	ISS	12588856	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00010	B cell activation	P00397	IKK	MOUSE|MGI=MGI=1338071|UniProtKB=O88351	Inhibitor of nuclear factor kappa-B kinase subunit beta	IGI	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	HUMAN|HGNC=1957|UniProtKB=P32297	Neuronal acetylcholine receptor subunit alpha-3	IC	12098588	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	SCHPO|PomBase=SPAC8C9.03|UniProtKB=P36600	cAMP-dependent protein kinase regulatory subunit	IC	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	BOVIN|Ensembl=ENSBTAG00000010830|UniProtKB=E1BGJ0	Uncharacterized protein	ISS	11907044	PubMed	PTHR44025:SF2	PROLOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	DANRE|ZFIN=ZDB-GENE-980526-527|UniProtKB=B3DJ37	Receptor protein serine/threonine kinase	TAS	9395284	PubMed	PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P00047	PDGF signaling pathway	P01153	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02736	Coenzyme A biosynthesis	P02883	Pantothenoylcysteine decarboxylase	ARATH|TAIR=AT1G48605|UniProtKB=P94063	Probable phosphopantothenoylcysteine decarboxylase	ISS			PTHR14359:SF6	PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	BOVIN|Gene=MYH7|UniProtKB=Q9BE39	Myosin-7	ISS	10938134	PubMed	PTHR13140:SF344	MYOSIN-7
P00011	Blood coagulation	P00422	FIXa	HUMAN|HGNC=3551|UniProtKB=P00740	Coagulation factor IX	ISS	14270099	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	IC	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00996	STAT	RAT|RGD=3772|UniProtKB=P52631	Signal transducer and activator of transcription 3	IC	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	CAEEL|WormBase=WBGene00000068|UniProtKB=Q19523	Adenylyl CYclase	IGI	22013858	PubMed	PTHR11920:SF319	ADENYLATE CYCLASE TYPE 9
P00006	Apoptosis signaling pathway	P00313	IKK	PANTR|Ensembl=ENSPTRG00000020202|UniProtKB=H2QW34	Uncharacterized protein	ISS	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00005	Angiogenesis	P00243	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00391	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00591	PLCbeta	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P02779	Thiamin biosynthesis	P03175	1-Deoxyxylulose-5-phosphate synthase	DEIRA|EnsemblGenome=DR_1475|UniProtKB=Q9RUB5	1-deoxy-D-xylulose-5-phosphate synthase	ISS			PTHR43322:SF5	1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE 1-RELATED
P00021	FGF signaling pathway	P00624	14-3-3	HUMAN|HGNC=12855|UniProtKB=P63104	14-3-3 protein zeta/delta	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P05913	Enkephalin release	P05974	G-Protein (i)	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00591	PLCbeta	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IGI	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	MACMU|Ensembl=ENSMMUG00000014334|UniProtKB=F7CYY6	Uncharacterized protein	ISS	11248120	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	MYCTU|EnsemblGenome=Rv0357c|UniProtKB=P9WHN3	Adenylosuccinate synthetase	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00017	DNA replication	P00527	Histones	DANRE|ZFIN=ZDB-GENE-080220-24|UniProtKB=A8KBJ5	Histone H3	ISS	12413958	PubMed	PTHR11426:SF167	HISTONE H3.1
P00047	PDGF signaling pathway	P01143	ERK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	MOUSE|MGI=MGI=106677|UniProtKB=Q8BRU6	Synaptic vesicular amine transporter	ISS	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00052	TGF-beta signaling pathway	P01276	Co-Smads	MONDO|Ensembl=ENSMODG00000010995|UniProtKB=F7A1M2	Mothers against decapentaplegic homolog	ISS	10693808	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	CHICK|Gene=PSEN2|UniProtKB=Q90X07	Presenilin-2	TAS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00059	p53 pathway	P04634	Cdc2	PLAF7|EnsemblGenome=MAL13P1.279|UniProtKB=P61075	Cell division control protein 2 homolog	ISS			PTHR24056:SF46	CYCLIN-DEPENDENT-LIKE KINASE 5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=18150|UniProtKB=Q8IUG5	Unconventional myosin-XVIIIb	IC			PTHR13140:SF372	UNCONVENTIONAL MYOSIN-XVIIIB
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00019	Endothelin signaling pathway	P00566	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04547	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P00006	Apoptosis signaling pathway	P00303	c-Jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P02757	O-antigen biosynthesis	P03045	dTDP-glucose 4,6-dehydratase	CAEEL|WormBase=WBGene00018737|UniProtKB=Q20697	Uncharacterized protein	ISS			PTHR43000:SF6	SUBFAMILY NOT NAMED
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	IDA	12169092	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	EMENI|EnsemblGenome=CADANIAG00006588|UniProtKB=Q9HFQ2	Serine/threonine-protein phosphatase PP2A catalytic subunit	ISS			PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P02736	Coenzyme A biosynthesis	P02883	Pantothenoylcysteine decarboxylase	DEIRA|EnsemblGenome=DR_0579|UniProtKB=Q9RWT6	DNA/pantothenate metabolism flavoprotein	ISS			PTHR14359:SF6	PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	STRCO|EnsemblGenome=CAB75393|UniProtKB=P50589	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00015	Circadian clock system	G01497	cry	PANTR|Ensembl=ENSPTRG00000003537|UniProtKB=H2Q3H0	Uncharacterized protein	ISS	11533252	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00019	Endothelin signaling pathway	P00572	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00010	B cell activation	P00376	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00010	B cell activation	P00373	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IGI	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=96284|UniProtKB=P31387	5-hydroxytryptamine receptor 5B	IDA	12181435	PubMed	PTHR24247:SF14	5-HYDROXYTRYPTAMINE RECEPTOR 5B
P02776	Serine glycine biosynthesis	P03159	Phosphoserine phosphatase	PSEAE|EnsemblGenome=PA4960|UniProtKB=Q9HUK5	Probable phosphoserine phosphatase	ISS			PTHR43344:SF2	PHOSPHOSERINE PHOSPHATASE
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	XENTR|Xenbase=XB-GENE-945015|UniProtKB=F6QA46	Uncharacterized protein	ISS	11390664	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P04395	Vasopressin synthesis	P04593	Glycopeptide	PANTR|Ensembl=ENSPTRG00000013189|UniProtKB=H2QJV1	Uncharacterized protein	ISS	6717565	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00060	Ubiquitin proteasome pathway	P01491	E2	PANTR|Ensembl=ENSPTRG00000011507|UniProtKB=H2QH65	Uncharacterized protein	ISS			PTHR44066:SF1	UBIQUITIN-CONJUGATING ENZYME E2 S
P00057	Wnt signaling pathway	P01457	GBeta	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	RCA	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00056	VEGF signaling pathway	P01413	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01409	cPLA2	CANLF|Ensembl=ENSCAFG00000013778|UniProtKB=F6UQ33	Phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	IXOSC|EnsemblGenome=ISCW014549|UniProtKB=B7QGY5	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	RCA	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	HUMAN|HGNC=2458|UniProtKB=Q8NEV1	Casein kinase II subunit alpha 3	IDA	10806215	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	XENTR|Xenbase=XB-GENE-956713|UniProtKB=Q5XGD8	Guanine nucleotide binding protein, beta 3	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	YEAST|SGD=S000003700|UniProtKB=P06244	cAMP-dependent protein kinase type 1	ISS	89107990	PubMed	PTHR24353:SF73	CAMP-DEPENDENT PROTEIN KINASE TYPE 1-RELATED
P00006	Apoptosis signaling pathway	P00269	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	ARATH|TAIR=AT4G34460|UniProtKB=P49177	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF48	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	HUMAN|HGNC=7774|UniProtKB=O94916	Nuclear factor of activated T-cells 5	ISS			PTHR12533:SF10	NUCLEAR FACTOR OF ACTIVATED T-CELLS 5
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	DICDI|dictyBase=DDB_G0269196|UniProtKB=P32256	Tubulin beta chain	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00049	Parkinson disease	P01215	Syntaxin	MACMU|Ensembl=ENSMMUG00000004994|UniProtKB=F7ATP9	Syntaxin-7	ISS	10321247	PubMed	PTHR19957:SF90	SYNTAXIN-7
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00047	PDGF signaling pathway	P01143	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00036	Interleukin signaling pathway	P00985	PDK1/2	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00017	DNA replication	P00532	Hel	PANTR|Ensembl=ENSPTRG00000002556|UniProtKB=H2Q1Z5	Uncharacterized protein	RCA			PTHR10887:SF14	DNA REPLICATION ATP-DEPENDENT HELICASE/NUCLEASE DNA2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00045	Notch signaling pathway	P01118	Numb	PANTR|Ensembl=ENSPTRG00000006513|UniProtKB=H2R3J4	Uncharacterized protein	ISS	8755477	PubMed	PTHR11232:SF33	PROTEIN NUMB HOMOLOG
P00005	Angiogenesis	P00181	SHP2	DANRE|ZFIN=ZDB-GENE-030131-5911|UniProtKB=F1QZU5	Tyrosine-protein phosphatase non-receptor type	ISS	95163101	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00053	T cell activation	P01303	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	8262390	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00058	mRNA splicing	P01475	U2AF65	PANTR|Ensembl=ENSPTRG00000021693|UniProtKB=H2R2N6	Uncharacterized protein	ISS			PTHR12620:SF28	U2 SMALL NUCLEAR RIBONUCLEOPROTEIN AUXILIARY FACTOR 35 KDA SUBUNIT-RELATED PROTEIN 2
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00036	Interleukin signaling pathway	P00983	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IC	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00048	PI3 kinase pathway	P01185	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00034	Integrin signalling pathway	P00916	Ras	DANRE|ZFIN=ZDB-GENE-040808-67|UniProtKB=Q6AZA4	K-ras	ISS	20362513	PubMed	PTHR24070:SF186	GTPASE KRAS
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	SCHPO|PomBase=SPAC806.07|UniProtKB=P49740	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00005	Angiogenesis	P00253	Axin	CANLF|Ensembl=ENSCAFG00000011236|UniProtKB=E2R9F8	Uncharacterized protein	ISS	9554852	PubMed	PTHR10845:SF103	AXIN-2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	HUMAN|HGNC=4581|UniProtKB=Q13003	Glutamate receptor ionotropic, kainate 3	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00057	Wnt signaling pathway	P01465	Ggamma	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00046	Oxidative stress response	P01135	p38	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	TAS	4506785	gi	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00213	FGF	ORNAN|Ensembl=ENSOANG00000014242|UniProtKB=F6WG78	Fibroblast growth factor	ISS	12799194	PubMed	PTHR11486:SF86	FIBROBLAST GROWTH FACTOR 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	IDA	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02759	Pyridoxal-5-phosphate biosynthesis	P03061	Pyridoxine-5-phosphate oxidase	MYCTU|EnsemblGenome=Rv2607|UniProtKB=P9WIJ1	Pyridoxine/pyridoxamine 5'-phosphate oxidase	ISS	9634230	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00060	Ubiquitin proteasome pathway	P01491	E2	HUMAN|HGNC=4914|UniProtKB=P61086	Ubiquitin-conjugating enzyme E2 K	ISS			PTHR44020:SF2	UBIQUITIN-CONJUGATING ENZYME E2 K
P00029	Huntington disease	P00796	Kainate receptor	PANTR|Ensembl=ENSPTRG00000013825|UniProtKB=H2RAK4	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P01486	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00629	PP2A	PLAF7|EnsemblGenome=PFC0595c|UniProtKB=O97259	Serine/threonine-protein phosphatase	ISS			PTHR11668:SF400	SUBFAMILY NOT NAMED
P00059	p53 pathway	G04702	p53	BOVIN|Ensembl=ENSBTAG00000015460|UniProtKB=F1MKA9	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P04393	Ras Pathway	P04567	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00045	Notch signaling pathway	P01099	Notch	RAT|RGD=3187|UniProtKB=Q07008	Neurogenic locus notch homolog protein 1	IEP	1764995	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00034	Integrin signalling pathway	P00941	Integrin alpha	CANLF|Ensembl=ENSCAFG00000018439|UniProtKB=J9NUT8	Uncharacterized protein	ISS	3487386	PubMed	PTHR23220:SF22	INTEGRIN ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	RAT|RGD=2344|UniProtKB=P08485	Muscarinic acetylcholine receptor M4	TAS	91373358	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P05912	Dopamine receptor mediated signaling pathway	P05949	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12186904	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00018	EGF receptor signaling pathway	P00546	GAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	IGI	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00045	Notch signaling pathway	G01541	E(spl)-C genes	MACMU|Ensembl=ENSMMUG00000014688|UniProtKB=F7GTZ1	Uncharacterized protein	ISS	14973298	PubMed	PTHR10985:SF104	TRANSCRIPTION FACTOR HES-5
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00019	Endothelin signaling pathway	P00586	Gq	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IGI	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00017	DNA replication	P00527	Histones	SCHMA|EnsemblGenome=Smp_082240|UniProtKB=C4QJB5	Histone H3	ISS	12413958	PubMed	PTHR11426:SF182	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01063	CAT	BOVIN|Ensembl=ENSBTAG00000016814|UniProtKB=F1MLQ5	Uncharacterized protein	ISS	92155737	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02728	Arginine biosynthesis	P02841	argininosuccinate lyase	CANLF|Ensembl=ENSCAFG00000010332|UniProtKB=F1PPR8	Uncharacterized protein	ISS			PTHR43814:SF1	ARGININOSUCCINATE LYASE
P00059	p53 pathway	P04609	PI3K	XENTR|Xenbase=XB-GENE-6067221|UniProtKB=F6Z0J4	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00010	B cell activation	P00374	Lyn	PANTR|Ensembl=ENSPTRG00000020263|UniProtKB=H2R453	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00005	Angiogenesis	P00211	GSK3beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	PANTR|Ensembl=ENSPTRG00000018669|UniProtKB=H2QTU8	Adenosine deaminase, tRNA-specific 2, TAD2 homolog	ISS			PTHR11079:SF92	TRNA-SPECIFIC ADENOSINE DEAMINASE 2
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04407	K+ channel	PANTR|Ensembl=ENSPTRG00000020614|UniProtKB=H2QWR7	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00025	Hedgehog signaling pathway	P00691	CBP	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00029	Huntington disease	P00775	Rac	MONDO|Ensembl=ENSMODG00000003244|UniProtKB=F6THF0	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	CAEEL|WormBase=WBGene00004860|UniProtKB=Q09488	Serine/threonine-protein kinase sma-6	TAS	10683140	PubMed	PTHR23255:SF68	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00021	FGF signaling pathway	P00623	FGF	HUMAN|HGNC=3671|UniProtKB=Q92915	Fibroblast growth factor 14	ISS	12123606	PubMed	PTHR11486:SF18	FIBROBLAST GROWTH FACTOR 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	CHICK|Ensembl=ENSGALG00000013731|UniProtKB=B2WUP2	Suppressor of cytokine signaling 6	ISS	15032587	PubMed	PTHR44562:SF1	SUPPRESSOR OF CYTOKINE SIGNALING 6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00056	VEGF signaling pathway	P01407	Erk	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	BOVIN|Ensembl=ENSBTAG00000014828|UniProtKB=F1N1E0	Uncharacterized protein	ISS	14624853	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	CAEEL|WormBase=WBGene00001745|UniProtKB=Q7KPV0	G protein, Subunit Alpha	ISS			PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00562	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00006	Apoptosis signaling pathway	P00307	ELF2alpha	BOVIN|Ensembl=ENSBTAG00000016311|UniProtKB=P68102	Eukaryotic translation initiation factor 2 subunit 1	ISS	10889505	PubMed	PTHR10602:SF0	EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ARATH|TAIR=AT5G59370|UniProtKB=P53494	Actin-4	ISS	14684598	PubMed	PTHR11937:SF366	ACTIN-4
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00034	Integrin signalling pathway	P00924	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IPI	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01414	PLC-gamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	MOUSE|MGI=MGI=1928679|UniProtKB=Q9EQF5	Dihydropyrimidinase	ISS	9718352	PubMed	PTHR11647:SF50	DIHYDROPYRIMIDINASE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00047	PDGF signaling pathway	P01150	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g161273|UniProtKB=A7RPJ6	Predicted protein	ISS	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	PANTR|Ensembl=ENSPTRG00000002149|UniProtKB=H2R0U9	Uncharacterized protein	ISS	8930069	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	CANLF|Ensembl=ENSCAFG00000002528|UniProtKB=F1PS63	Receptor protein serine/threonine kinase	ISS			PTHR23255:SF61	TGF-BETA RECEPTOR TYPE-1
P00054	Toll receptor signaling pathway	P01357	MEKK1	RAT|RGD=620966|UniProtKB=Q62925	Mitogen-activated protein kinase kinase kinase 1	ISS	8643568	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00021	FGF signaling pathway	P00636	FGFR1-4	PANTR|Ensembl=ENSPTRG00000003003|UniProtKB=H2Q2P3	Fibroblast growth factor receptor	ISS	10626794	PubMed	PTHR24416:SF130	FIBROBLAST GROWTH FACTOR RECEPTOR 2
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	DANRE|ZFIN=ZDB-GENE-050706-89|UniProtKB=F1RDG9	Tyrosine-protein kinase fynb	ISS	9741627	PubMed	PTHR24418:SF242	TYROSINE-PROTEIN KINASE FYNB
P00044	Nicotinic acetylcholine receptor signaling pathway	P01093	AChE	BRAFL|Gene=BRAFLDRAFT_132597|UniProtKB=C3ZRW7	Carboxylic ester hydrolase	ISS	86008285	PubMed	PTHR11559:SF356	ACETYLCHOLINESTERASE
P00049	Parkinson disease	P01236	Casein kinase II	TAKRU|Ensembl=ENSTRUG00000016144|UniProtKB=H2UWE3	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P06664	Gonadotropin-releasing hormone receptor pathway	P06852	nPKCs	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	RCA	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	ORNAN|Ensembl=ENSOANG00000006877|UniProtKB=F7CQF2	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00056	VEGF signaling pathway	P01411	Ras	DICPU|Gene=DICPUDRAFT_57324|UniProtKB=F0ZVH9	Putative uncharacterized protein rasS	ISS	94119591	PubMed	PTHR24070:SF380	RAS-LIKE PROTEIN RASS
P00011	Blood coagulation	P00451	Kininogen	HUMAN|HGNC=6383|UniProtKB=P01042	Kininogen-1	ISS	125507	gi	PTHR13814:SF12	KININOGEN-1
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00807	Actin	STRPU|EnsemblGenome=SPU_006797|UniProtKB=W4XTP5	Uncharacterized protein	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00059	p53 pathway	G04696	Siah	CHICK|Ensembl=ENSGALG00000003916|UniProtKB=F1P2G0	E3 ubiquitin-protein ligase	ISS	14985507	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00018	EGF receptor signaling pathway	P00552	Ras	MOUSE|MGI=MGI=98179|UniProtKB=P10833	Ras-related protein R-Ras	ISS	7997267	PubMed	PTHR24070:SF245	RAS-RELATED PROTEIN R-RAS
P00048	PI3 kinase pathway	P01177	P110ACT	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06210	Activin beta signaling pathway	P06229	PUT	DROME|Gene=Dmel_CG7904|UniProtKB=A0A0B4KG59	Serine/threonine-protein kinase receptor	IEA	http://flybase.org/reports/FBgn0003169.html	Website	PTHR23255:SF70	SERINE/THREONINE-PROTEIN KINASE RECEPTOR
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01428	Frizzled	BOVIN|Ensembl=ENSBTAG00000035084|UniProtKB=F1MLG5	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF22	FRIZZLED-3
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00059	p53 pathway	P04616	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00046	Oxidative stress response	P01131	MKP5	MACMU|Ensembl=ENSMMUG00000002351|UniProtKB=F7C5I2	Dual specificity protein phosphatase 3	ISS			PTHR10159:SF485	DUAL SPECIFICITY PROTEIN PHOSPHATASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	MACMU|Ensembl=ENSMMUG00000018571|UniProtKB=F6YLU2	Uncharacterized protein	RCA			PTHR22952:SF24	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 1
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	PANTR|Ensembl=ENSPTRG00000020039|UniProtKB=H2R9W1	Uncharacterized protein	ISS	11443533	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00005	Angiogenesis	P00253	Axin	XENTR|Xenbase=XB-GENE-486781|UniProtKB=F6XWP7	Uncharacterized protein	ISS	12356903	PubMed	PTHR10845:SF11	AXIN-1
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00006	Apoptosis signaling pathway	P00274	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00019	Endothelin signaling pathway	P00568	PKC	DANRE|ZFIN=ZDB-GENE-040426-1354|UniProtKB=Q7T2C5	Protein kinase C	ISS	11880265	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00048	PI3 kinase pathway	P01188	Gbetagamma	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	RAT|RGD=3921|UniProtKB=P45352	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10755300	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00047	PDGF signaling pathway	P01149	MNK1/2	BOVIN|Gene=MKNK1|UniProtKB=Q58D94	MAP kinase-interacting serine/threonine-protein kinase 1	ISS	9155018	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01451	Galpha	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IDA	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04397	p53 pathway by glucose deprivation	P04637	4E-BP1	RAT|RGD=620259|UniProtKB=Q62622	Eukaryotic translation initiation factor 4E-binding protein 1	IDA	15494402	PubMed	PTHR12669:SF14	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1
P00005	Angiogenesis	P00226	Delta/Serrate	HUMAN|HGNC=6188|UniProtKB=P78504	Protein jagged-1	IDA	1286675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00029	Huntington disease	P00779	TBP	HALSA|EnsemblGenome=VNG_6438G|UniProtKB=Q9HHE9	TATA-box-binding protein F	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	DROME|FlyBase=FBgn0027341|UniProtKB=Q7PLC7	Glutamine:fructose-6-phosphate aminotransferase 1, isoform A	ISS			PTHR10937:SF0	GH12731P-RELATED
P00049	Parkinson disease	P01227	20S proteasome	DROME|FlyBase=FBgn0017556|UniProtKB=Q27575	Proteasome subunit alpha type-7-1B	TAS	12859888	PubMed	PTHR11599:SF15	PROTEASOME SUBUNIT ALPHA TYPE
P00029	Huntington disease	P00799	JNK-2	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04398	p53 pathway feedback loops 2	P04668	p53	DANRE|ZFIN=ZDB-GENE-030814-2|UniProtKB=B0S576	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00021	FGF signaling pathway	P00627	ERK1-2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	HUMAN|HGNC=7576|UniProtKB=P13533	Myosin-6	IEP	89264452	PubMed	PTHR13140:SF721	MYOSIN-6
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	SCHMA|EnsemblGenome=Smp_161920|UniProtKB=G4VSW5	Putative actin	IC	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00865	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	10982827	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00006	Apoptosis signaling pathway	P00310	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IDA	10799299	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	BOVIN|Ensembl=ENSBTAG00000019210|UniProtKB=F1MJV4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	MOUSE|MGI=MGI=99600|UniProtKB=P47738	Aldehyde dehydrogenase, mitochondrial	IC			PTHR11699:SF233	ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00054	Toll receptor signaling pathway	P01355	AP1	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	BOVIN|Ensembl=ENSBTAG00000031363|UniProtKB=F1MP44	Uncharacterized protein	ISS	9783586	PubMed	PTHR10814:SF4	AMINO-TERMINAL ENHANCER OF SPLIT-RELATED
P05731	GABA-B receptor II signaling	P05755	Gbeta	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	PANTR|Ensembl=ENSPTRG00000010559|UniProtKB=H2QFI5	Uncharacterized protein	ISS	10839363	PubMed	PTHR19957:SF106	SYNTAXIN-10
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P06959	CCKR signaling map	G07271	CHGA	HUMAN|HGNC=1929|UniProtKB=P10645	Chromogranin-A	RCA	12456801	PubMed	PTHR10583:SF1	CHROMOGRANIN-A
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01084	CHT1	BOVIN|Ensembl=ENSBTAG00000004352|UniProtKB=Q2KI26	Solute carrier family 5 (Choline transporter), member 7	RCA			PTHR11819:SF129	HIGH AFFINITY CHOLINE TRANSPORTER 1
P00053	T cell activation	P01320	PLC-gamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06832	c-Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	RCA	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00036	Interleukin signaling pathway	P00990	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00057	Wnt signaling pathway	P01444	Wnt	ANOGA|EnsemblGenome=AGAP009731|UniProtKB=Q7PM77	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF98	PROTEIN WNT-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01330	IKK	BOVIN|Ensembl=ENSBTAG00000007591|UniProtKB=Q95KV1	Inhibitor of nuclear factor kappa-B kinase subunit alpha	IGI	14499113	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01152	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	14707121	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00007	Axon guidance mediated by semaphorins	P00340	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	10891487	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00040	Metabotropic glutamate receptor group II pathway	G01540	BDNF	DANRE|ZFIN=ZDB-GENE-000412-1|UniProtKB=Q6NZ01	Bdnf protein	ISS	11408619	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00018	EGF receptor signaling pathway	P00559	MEK1-2	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04397	p53 pathway by glucose deprivation	P04644	TSC2	TAKRU|Ensembl=ENSTRUG00000008958|UniProtKB=H2TCY4	Uncharacterized protein	ISS	15249583	PubMed	PTHR10063:SF0	TUBERIN
P00052	TGF-beta signaling pathway	P01292	RSmads	DROME|FlyBase=FBgn0011648|UniProtKB=P42003	Protein mothers against dpp	TAS	7768443	PubMed	PTHR13703:SF40	PROTEIN MOTHERS AGAINST DPP
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	G04696	Siah	MOUSE|MGI=MGI=108064|UniProtKB=P61092	E3 ubiquitin-protein ligase SIAH1A	ISS	14985507	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00005	Angiogenesis	P00223	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	BOVIN|Ensembl=ENSBTAG00000018777|UniProtKB=E1BHU9	Uncharacterized protein	ISS	94139935	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	RAT|RGD=628837|UniProtKB=P60711	Actin, cytoplasmic 1	IC	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00060	Ubiquitin proteasome pathway	P01491	E2	BOVIN|Ensembl=ENSBTAG00000016746|UniProtKB=Q32PA5	Ubiquitin-conjugating enzyme E2 C	ISS			PTHR44189:SF1	UBIQUITIN-CONJUGATING ENZYME E2 C
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	TAS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00206	Wnt	MOUSE|MGI=MGI=1261834|UniProtKB=O70283	Protein Wnt-2b	ISS	11266476	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P02755	Methylmalonyl pathway	P03034	Methylmalonyl-CoA mutase	MOUSE|MGI=MGI=97239|UniProtKB=P16332	Methylmalonyl-CoA mutase, mitochondrial	ISS			PTHR42710:SF1	METHYLMALONYL-COA MUTASE, MITOCHONDRIAL
P00034	Integrin signalling pathway	P00923	Arf1	BRAFL|Gene=BRAFLDRAFT_263946|UniProtKB=C3Z3B1	Putative uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF304	ADP-RIBOSYLATION FACTOR 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00045	Notch signaling pathway	P01099	Notch	PANTR|Ensembl=ENSPTRG00000034379|UniProtKB=H2RDK4	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=11438|UniProtKB=Q13277	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	PSEAE|EnsemblGenome=PA5497|UniProtKB=Q9HT76	NrdJa	ISS			PTHR43371:SF1	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MOUSE|MGI=MGI=1339713|UniProtKB=Q5SX39	Myosin-4	ISS	10938134	PubMed	PTHR13140:SF657	MYOSIN-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CAEEL|WormBase=WBGene00000064|UniProtKB=P10984	Actin-2	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00048	PI3 kinase pathway	G01546	Cyclin d	BOVIN|Ensembl=ENSBTAG00000016649|UniProtKB=Q0P5D3	G1/S-specific cyclin-D2	ISS	93275661	PubMed	PTHR10177:SF66	G1/S-SPECIFIC CYCLIN-D2
P02776	Serine glycine biosynthesis	P03160	Phosphoglycerate dehydrogenase	PSEAE|EnsemblGenome=PA0316|UniProtKB=Q9I6H5	D-3-phosphoglycerate dehydrogenase	ISS			PTHR10996:SF165	D-3-PHOSPHOGLYCERATE DEHYDROGENASE 1-RELATED
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01435	SWI/SNF	CANLF|Ensembl=ENSCAFG00000007525|UniProtKB=E2QWV0	Uncharacterized protein	ISS	11532957	PubMed	PTHR10799:SF887	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5
P04393	Ras Pathway	P04572	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00054	Toll receptor signaling pathway	P01375	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02783	Tryptophan biosynthesis	P03208	Tryptophan synthase B	YEAST|SGD=S000002994|UniProtKB=P00931	Tryptophan synthase	ISS			PTHR42882:SF1	TRYPTOPHAN SYNTHASE
P00029	Huntington disease	P00807	Actin	ASHGO|EnsemblGenome=AGOS_ABR222W|UniProtKB=Q75D00	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=1565392|UniProtKB=A0A0G2K8I5	Protein Pcdh19	ISS	8120095	PubMed	PTHR24028:SF40	PROTOCADHERIN-19
P00010	B cell activation	P00379	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	ARATH|TAIR=AT1G13890|UniProtKB=Q9LMG8	Putative SNAP25 homologous protein SNAP30	IC			PTHR19305:SF7	SNAP25 HOMOLOGOUS PROTEIN SNAP30-RELATED
P00005	Angiogenesis	P00205	GAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	88318957	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	BOVIN|Ensembl=ENSBTAG00000015670|UniProtKB=E1B7J7	Uncharacterized protein	ISS	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00029	Huntington disease	P00807	Actin	STRPU|Gene=CYIIIB|UniProtKB=P18499	Actin, cytoskeletal 3B	IDA	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05940	GRK5	MOUSE|MGI=MGI=109161|UniProtKB=Q8VEB1	G protein-coupled receptor kinase 5	RCA	8288567	PubMed	PTHR24355:SF27	G PROTEIN-COUPLED RECEPTOR KINASE 5
P00010	B cell activation	P00379	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	IGI	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00010	B cell activation	P00375	Calmodulin	MACMU|Ensembl=ENSMMUG00000028962|UniProtKB=F7EWG5	Uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF322	SUBFAMILY NOT NAMED
P06587	Nicotine pharmacodynamics pathway	P06607	EPB41	RAT|RGD=1564762|UniProtKB=A0A0G2K161	Uncharacterized protein	ISS	12181426	PubMed	PTHR23280:SF12	PROTEIN 4.1
P00056	VEGF signaling pathway	P01411	Ras	CAEEL|WormBase=WBGene00002335|UniProtKB=P22981	Ras protein let-60	ISS	22022015	PubMed	PTHR24070:SF385	GTPASE HRAS
P00010	B cell activation	P00371	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00009	Axon guidance mediated by netrin	P00364	cdc42	TAKRU|Ensembl=ENSTRUG00000013411|UniProtKB=H2UB84	Uncharacterized protein	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	DANRE|ZFIN=ZDB-GENE-040718-93|UniProtKB=Q6DGZ5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00006	Apoptosis signaling pathway	P00302	ATF	MONDO|Ensembl=ENSMODG00000009514|UniProtKB=F7EVK3	Uncharacterized protein	ISS	10664585	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05918	p38 MAPK pathway	P06015	p38gamma	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	RCA	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00010	B cell activation	P00385	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	IGI	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MOUSE|MGI=MGI=2152453|UniProtKB=Q2NL51	Glycogen synthase kinase-3 alpha	ISS	21361340	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00047	PDGF signaling pathway	P01161	Raf	DANRE|ZFIN=ZDB-GENE-040805-1|UniProtKB=Q1LYG2	Uncharacterized protein	ISS	3043188	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04384	Gamma-aminobutyric acid synthesis	P04480	GABA aminotransferase	CANLF|Ensembl=ENSCAFG00000019030|UniProtKB=E2R776	Uncharacterized protein	ISS	10989446	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05730	Endogenous cannabinoid signaling	P05751	Galpha	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00037	Ionotropic glutamate receptor pathway	P01020	NSF	CHICK|Ensembl=ENSGALG00000001055|UniProtKB=E1BQU4	Uncharacterized protein	ISS	7969419	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	RAT|RGD=1586637|UniProtKB=F1LMY4	Ryanodine receptor 1	ISS	8930069	PubMed	PTHR13715:SF15	RYANODINE RECEPTOR 1
P00019	Endothelin signaling pathway	P00589	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04372	5-Hydroxytryptamine degredation	P04401	Monoamine Oxidase	MACMU|Ensembl=ENSMMUG00000019492|UniProtKB=F7D3H3	Amine oxidase [flavin-containing]	ISS	8602220	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P00013	Cell cycle	P00489	CdkC	MACMU|Ensembl=ENSMMUG00000005358|UniProtKB=F6Q793	Uncharacterized protein	RCA			PTHR10177:SF70	G1/S-SPECIFIC CYCLIN-E2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	PANTR|Ensembl=ENSPTRG00000003795|UniProtKB=H2Q3X5	Muscarinic acetylcholine receptor	ISS	10069496	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00019	Endothelin signaling pathway	P00566	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000002658|UniProtKB=F7CB14	Uncharacterized protein	ISS	11248120	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00010	B cell activation	P00402	Jnk	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MACMU|Ensembl=ENSMMUG00000021442|UniProtKB=F7EAQ8	Muscarinic acetylcholine receptor	ISS	10069496	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00036	Interleukin signaling pathway	P00976	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00029	Huntington disease	P00805	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MOUSE|MGI=MGI=1196627|UniProtKB=Q9R1C8	5-hydroxytryptamine receptor 6	IDA	12181435	PubMed	PTHR24247:SF114	5-HYDROXYTRYPTAMINE RECEPTOR 6
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	IDA	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00029	Huntington disease	P00788	Calpain	RAT|RGD=70960|UniProtKB=O88501	Calpain-6	IDA	11675509	PubMed	PTHR10183:SF381	CALPAIN-6
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00037	Ionotropic glutamate receptor pathway	P01006	NR2C	HUMAN|HGNC=4588|UniProtKB=O15399	Glutamate receptor ionotropic, NMDA 2D	ISS			PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	BOVIN|Ensembl=ENSBTAG00000003955|UniProtKB=F1MHG0	Uncharacterized protein	ISS			PTHR13140:SF369	UNCONVENTIONAL MYOSIN-VIIA
P00025	Hedgehog signaling pathway	P00682	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	IC	15860573	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00035	Interferon-gamma signaling pathway	P00954	Interferongamma	RAT|RGD=2866|UniProtKB=P01581	Interferon gamma	TAS	11175845	PubMed	PTHR11419:SF0	INTERFERON GAMMA
P00046	Oxidative stress response	P01125	Stat1	TAKRU|Ensembl=ENSTRUG00000000102|UniProtKB=H2RJA9	Signal transducer and activator of transcription	ISS	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00046	Oxidative stress response	P01131	MKP5	CANLF|Ensembl=ENSCAFG00000006100|UniProtKB=E2R8S3	Dual specificity protein phosphatase	ISS			PTHR10159:SF45	DUAL SPECIFICITY PROTEIN PHOSPHATASE 6
P00047	PDGF signaling pathway	P01150	PKC	HUMAN|HGNC=9406|UniProtKB=Q16513	Serine/threonine-protein kinase N2	ISS	10644715	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00005	Angiogenesis	P00203	Erk	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00048	PI3 kinase pathway	P01192	p110	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00168	E-cadherin intracellular fragment	RAT|RGD=621089|UniProtKB=F1LMI3	Cadherin 3, type 1, P-cadherin (Placental)	ISS	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P00005	Angiogenesis	P00203	Erk	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHICK|Ensembl=ENSGALG00000014620|UniProtKB=F1N8P3	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04563	Ets	MACMU|Ensembl=ENSMMUG00000020706|UniProtKB=F6PU72	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00059	p53 pathway	G01575	GADD45	PANTR|Ensembl=ENSPTRG00000024024|UniProtKB=H2R6I0	Growth arrest and DNA-damage-inducible, beta	ISS	10097101	PubMed	PTHR10411:SF5	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 BETA
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05915	Opioid proenkephalin pathway	P05992	met-Enkephalin	MACMU|Ensembl=ENSMMUG00000006775|UniProtKB=F7H3N8	Uncharacterized protein	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00019	Endothelin signaling pathway	P00589	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00006	Apoptosis signaling pathway	P00318	PKCs	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IDA	7492337	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00010	B cell activation	P00367	NFAT	PANTR|Ensembl=ENSPTRG00000008260|UniProtKB=H2QBD7	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	ISS	9133421	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g242065|UniProtKB=A7S0V7	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00052	TGF-beta signaling pathway	P01292	RSmads	SCHMA|EnsemblGenome=Smp_085910|UniProtKB=G4LUM0	Mothers against decapentaplegic homolog	TAS	9395284	PubMed	PTHR13703:SF25	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04658	PTEN	DROME|FlyBase=FBgn0026379|UniProtKB=Q7KMQ6	IP16020p	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P00036	Interleukin signaling pathway	P00981	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00059	p53 pathway	P01486	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	20855874	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CAEBR|Gene=CBG02161|UniProtKB=A8WS32	Protein CBG02161	ISS	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00010	B cell activation	P00398	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IGI	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00632	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00046	Oxidative stress response	P01126	ATF2	HUMAN|HGNC=784|UniProtKB=P15336	Cyclic AMP-dependent transcription factor ATF-2	TAS	10207617	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00009	Axon guidance mediated by netrin	P00359	NFAT	RAT|RGD=1310749|UniProtKB=D3Z9H7	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	ISS	12787506	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00034	Integrin signalling pathway	P00927	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DROME|FlyBase=FBgn0000042|UniProtKB=P10987	Actin-5C	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01398	TFIIEalpha	PANTR|Ensembl=ENSPTRG00000015273|UniProtKB=H2QN66	General transcription factor IIE, polypeptide 1, alpha 56kDa	ISS	189964	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00047	PDGF signaling pathway	P01142	p90RSK	CANLF|Ensembl=ENSCAFG00000017679|UniProtKB=E2RMD8	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00014	Cholesterol biosynthesis	P00491	Hydroxymethyl glutaryl CoA reductase	DICDI|dictyBase=DDB_G0269142|UniProtKB=P34135	3-hydroxy-3-methylglutaryl-coenzyme A reductase 1	TAS	P34135	SPACC	PTHR10572:SF2	3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00005	Angiogenesis	P00255	Notch	MACMU|Ensembl=ENSMMUG00000018375|UniProtKB=F7H1D5	Neurogenic locus notch homolog protein 2 isoform 1 preproprotein	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00018	EGF receptor signaling pathway	P00552	Ras	DANRE|ZFIN=ZDB-GENE-040808-67|UniProtKB=Q6AZA4	K-ras	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00521	Profilin	SCHPO|PomBase=SPAC4A8.15c|UniProtKB=P39825	Profilin	ISS			PTHR11604:SF0	PROFILIN
P00025	Hedgehog signaling pathway	P00682	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	HUMAN|HGNC=8590|UniProtKB=Q13153	Serine/threonine-protein kinase PAK 1	ISS	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01098	CHT1	MACMU|Ensembl=ENSMMUG00000010166|UniProtKB=F6QHN1	Uncharacterized protein	RCA			PTHR11819:SF129	HIGH AFFINITY CHOLINE TRANSPORTER 1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00648	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00049	Parkinson disease	P01211	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	13620175	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=2136750|UniProtKB=Q91Y04	Protein Pcdhb15	IDA	8120095	PubMed	PTHR24028:SF69	PROTOCADHERIN BETA-7
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00034	Integrin signalling pathway	P00948	Rho	MOUSE|MGI=MGI=106028|UniProtKB=Q62159	Rho-related GTP-binding protein RhoC	IGI	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	TAS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00006	Apoptosis signaling pathway	P00310	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	ANOGA|EnsemblGenome=AGAP003578|UniProtKB=Q7QAQ9	AGAP003578-PA	IC			PTHR11699:SF264	SUBFAMILY NOT NAMED
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MOUSE|MGI=MGI=107812|UniProtKB=P99024	Tubulin beta-5 chain	ISS	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	CAEBR|Gene=CBG02167|UniProtKB=A8WS37	Protein CBG02167	ISS	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00018	EGF receptor signaling pathway	P00543	ERK1-2	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04567	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00048	PI3 kinase pathway	P01181	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04393	Ras Pathway	P04553	PAK	MACMU|Ensembl=ENSMMUG00000001387|UniProtKB=F7D0B4	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00564	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	10540223	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	HUMAN|HGNC=7881|UniProtKB=P46531	Neurogenic locus notch homolog protein 1	IDA	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P04393	Ras Pathway	P04569	Cdc42	TAKRU|Ensembl=ENSTRUG00000013411|UniProtKB=H2UB84	Uncharacterized protein	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	RCA	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00047	PDGF signaling pathway	P01173	STAT	CANLF|Ensembl=ENSCAFG00000015346|UniProtKB=E2RE22	Signal transducer and activator of transcription	ISS	10835485	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000003128|UniProtKB=H2Q2V4	Uncharacterized protein	ISS	11248120	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00036	Interleukin signaling pathway	P00965	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00624	14-3-3	ORYSJ|EnsemblGenome=OS11G0546900|UniProtKB=Q2R2W2	14-3-3-like protein GF14-D	ISS	10407019	PubMed	PTHR18860:SF34	SUBFAMILY NOT NAMED
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	TAS	1169551	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00049	Parkinson disease	P01230	Src kinase	DROME|FlyBase=FBgn0264959|UniProtKB=Q9V9J3	Tyrosine-protein kinase Src42A	IDA	11078745	PubMed	PTHR24418:SF292	TYROSINE-PROTEIN KINASE SRC42A
P00019	Endothelin signaling pathway	P00590	IP3 R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00005	Angiogenesis	P00212	EphR	RAT|RGD=68389|UniProtKB=O08680	Ephrin type-A receptor 3	ISS			PTHR24416:SF18	EPHRIN TYPE-A RECEPTOR 3
P05916	Opioid prodynorphin pathway	P06002	G-protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01324	rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00029	Huntington disease	P00771	Sin3A	HUMAN|HGNC=19354|UniProtKB=O75182	Paired amphipathic helix protein Sin3b	IDA	10441327	PubMed	PTHR12346:SF1	PAIRED AMPHIPATHIC HELIX PROTEIN SIN3B
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00050	Plasminogen activating cascade	P01245	PAI-1	MACMU|Ensembl=ENSMMUG00000009926|UniProtKB=F6Y5D7	Uncharacterized protein	ISS	10692390	PubMed	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00049	Parkinson disease	P01212	p38 MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	NAS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	MONDO|Ensembl=ENSMODG00000015970|UniProtKB=F7FD05	Uncharacterized protein	RCA			PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	CAEBR|Gene=CBG02247|UniProtKB=A8WS68	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DROME|FlyBase=FBgn0013343|UniProtKB=Q24547	Syntaxin-1A	IC			PTHR19957:SF41	SYNTAXIN-1A
P05730	Endogenous cannabinoid signaling	P05746	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00047	PDGF signaling pathway	P01168	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00205	GAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	11847220	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IDA	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	BOVIN|Ensembl=ENSBTAG00000002283|UniProtKB=F1N4K7	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF31	FRIZZLED-7
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	IDA	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	94280860	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	DICPU|Gene=DICPUDRAFT_26270|UniProtKB=F0Z8A7	Protein serine/threonine kinase	ISS	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00029	Huntington disease	P00780	Microtubule	PANTR|Ensembl=ENSPTRG00000008496|UniProtKB=H2QBS3	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00047	PDGF signaling pathway	P01162	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00018	EGF receptor signaling pathway	P00563	Gab	RAT|RGD=621367|UniProtKB=Q9EQH1	GRB2-associated-binding protein 2	IGI	16758156	gi	PTHR12156:SF4	GRB2-ASSOCIATED-BINDING PROTEIN 2
P00021	FGF signaling pathway	P00644	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IGI	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00050	Plasminogen activating cascade	P01245	PAI-1	HUMAN|HGNC=8583|UniProtKB=P05121	Plasminogen activator inhibitor 1	ISS	18092159	gi	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00025	Hedgehog signaling pathway	P00682	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00049	Parkinson disease	P01241	TH	CHICK|Ensembl=ENSGALG00000006551|UniProtKB=F6RRW6	Uncharacterized protein	TAS	12480184	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00002	Alpha adrenergic receptor signaling pathway	P00078	Alpha1A/1B/1C	HUMAN|HGNC=277|UniProtKB=P35348	Alpha-1A adrenergic receptor	IC	11781138	PubMed	PTHR24248:SF16	ALPHA-1A ADRENERGIC RECEPTOR
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	TAS	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01322	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00034	Integrin signalling pathway	P00917	ELMO	RAT|RGD=1308182|UniProtKB=G8CYZ7	Engulfment and cell motility 1 splice 1 variant	ISS	12879077	PubMed	PTHR12771:SF23	ENGULFMENT AND CELL MOTILITY PROTEIN 1
P04393	Ras Pathway	P04558	p38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IDA	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	XENTR|Gene=wnt11b-1|UniProtKB=Q66II0	Protein Wnt-11b-1	ISS	8717036	PubMed	PTHR12027:SF34	PROTEIN WNT
P04395	Vasopressin synthesis	P04593	Glycopeptide	RAT|RGD=3238|UniProtKB=P01179	Oxytocin-neurophysin 1	IC	9756087	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	RCA			PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CHICK|Gene=CHRM3|UniProtKB=P49578	Muscarinic acetylcholine receptor M3	IDA	12915051	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_125401|UniProtKB=C3ZTX6	Putative uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00019	Endothelin signaling pathway	P00585	ECE1-3	CAEBR|Gene=CBG04739|UniProtKB=A8WYC8	Protein CBG04739	ISS			PTHR11733:SF192	NEPRILYSIN-21
P00029	Huntington disease	P00797	p53	RAT|RGD=1307083|UniProtKB=D4AA88	Protein Tp73	ISS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00017	DNA replication	P00533	Pol delta	HUMAN|HGNC=9175|UniProtKB=P28340	DNA polymerase delta catalytic subunit	ISS	92089082	PubMed	PTHR10322:SF23	DNA POLYMERASE DELTA CATALYTIC SUBUNIT
P04398	p53 pathway feedback loops 2	P04657	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P01486	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04417	5HT transporter	BOVIN|Gene=SLC6A4|UniProtKB=Q9XT49	Sodium-dependent serotonin transporter	ISS	7681602	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00059	p53 pathway	P04624	Cdc25C	MOUSE|MGI=MGI=103198|UniProtKB=P48964	M-phase inducer phosphatase 1	ISS	12408658	gi	PTHR10828:SF46	M-PHASE INDUCER PHOSPHATASE 1
P00012	Cadherin signaling pathway	P00470	F-actin	CAEBR|Gene=CBG23090|UniProtKB=A8Y4R0	Protein CBG23090	ISS	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BOVIN|Ensembl=ENSBTAG00000005714|UniProtKB=Q3ZC07	Actin, alpha cardiac muscle 1	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00005	Angiogenesis	P00254	GTPase	TRIAD|EnsemblGenome=TriadG20369|UniProtKB=B3RIM6	Putative uncharacterized protein	ISS			PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00036	Interleukin signaling pathway	P00976	GSK3	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00128	Erb-B4	HUMAN|HGNC=3432|UniProtKB=Q15303	Receptor tyrosine-protein kinase erbB-4	IDA	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P02743	Formyltetrahydroformate biosynthesis	P02956	Formyl tetrahydrofolate deformylase	ECOLI|EcoGene=EG11819|UniProtKB=P37051	Formyltetrahydrofolate deformylase	RCA			PTHR42706:SF1	FORMYLTETRAHYDROFOLATE DEFORMYLASE 1, MITOCHONDRIAL-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00022	General transcription by RNA polymerase I	P00657	TBP	ORNAN|Ensembl=ENSOANG00000013097|UniProtKB=F6UVN1	Uncharacterized protein	ISS	10082669	PubMed	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P06587	Nicotine pharmacodynamics pathway	P06604	SLC18A2	HUMAN|HGNC=10935|UniProtKB=Q05940	Synaptic vesicular amine transporter	TAS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=1310236|UniProtKB=D4A229	Serine/threonine-protein kinase	ISS	12676944	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	HUMAN|HGNC=1736|UniProtKB=P60953	Cell division control protein 42 homolog	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	HUMAN|HGNC=14079|UniProtKB=Q9UGM1	Neuronal acetylcholine receptor subunit alpha-9	IC			PTHR18945:SF489	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-9
P04393	Ras Pathway	P04560	AP1	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00297	NFkappaB	CANLF|Ensembl=ENSCAFG00000004597|UniProtKB=F1PJ94	Uncharacterized protein	ISS			PTHR24169:SF18	TRANSCRIPTION FACTOR RELB
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MOUSE|MGI=MGI=87885|UniProtKB=P04756	Acetylcholine receptor subunit alpha	IC	85270494	PubMed	PTHR18945:SF74	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00965	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MACMU|Ensembl=ENSMMUG00000009679|UniProtKB=F6YBQ8	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00056	VEGF signaling pathway	P01408	Akt/PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00560	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00790	beta-Tubulin	XENTR|Xenbase=XB-GENE-969447|UniProtKB=Q0IIR4	Tubulin, beta 2C	ISS	12932731	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P02728	Arginine biosynthesis	P02842	N-acetylornithine aminotransferase	DEIRA|EnsemblGenome=DR_0794|UniProtKB=Q9RW75	Acetylornithine/acetyl-lysine aminotransferase	ISS	10074354	PubMed	PTHR11986:SF79	ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL
P00059	p53 pathway	G01571	FAS	BOVIN|Ensembl=ENSBTAG00000010785|UniProtKB=P51867	Tumor necrosis factor receptor superfamily member 6	ISS	10327065	PubMed	PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P00018	EGF receptor signaling pathway	P00547	PP2A	ORNAN|Ensembl=ENSOANG00000005732|UniProtKB=F6X0X1	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	CHICK|Ensembl=ENSGALG00000003806|UniProtKB=O93467	GTP-binding protein	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P02770	Pyridoxal phosphate salvage pathway	P03120	Pyridoxamine-5-phosphate oxidase	DEIRA|EnsemblGenome=DR_0495|UniProtKB=Q9RX20	Pyridoxine/pyridoxamine 5'-phosphate oxidase	ISS	10567266	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04398	p53 pathway feedback loops 2	G04714	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00059	p53 pathway	G04694	p110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05994	G-protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05962	DAT	RAT|RGD=3715|UniProtKB=P23977	Sodium-dependent dopamine transporter	ISS	92107910	PubMed	PTHR11616:SF38	SODIUM-DEPENDENT DOPAMINE TRANSPORTER
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CAEEL|WormBase=WBGene00001615|UniProtKB=Q17697	GLutamate Receptor family (AMPA)	IC	10331083	PubMed	PTHR18966:SF352	GLUTAMATE RECEPTOR FAMILY  AMPA
P00021	FGF signaling pathway	P00638	PLCgamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IGI	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04397	p53 pathway by glucose deprivation	P04641	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TAKRU|Ensembl=ENSTRUG00000004787|UniProtKB=P53480	Actin, alpha cardiac	ISS	11889139	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00018	EGF receptor signaling pathway	P00565	PKC	YEAST|SGD=S000000201|UniProtKB=P24583	Protein kinase C-like 1	IGI	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00023	General transcription regulation	P00660	RNA Polymerase II	PANTR|Ensembl=ENSPTRG00000008157|UniProtKB=H2QB71	Polymerase (RNA) II (DNA directed) polypeptide C, 33kDa	ISS	2187864	PubMed	PTHR11800:SF2	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3
P06664	Gonadotropin-releasing hormone receptor pathway	P06798	PKCe/theta	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	ARATH|TAIR=AT1G60490|UniProtKB=P42339	Phosphatidylinositol 3-kinase VPS34	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00048	PI3 kinase pathway	P01177	P110ACT	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P04616	PDK1/2	ARATH|TAIR=AT5G04510|UniProtKB=Q9XF67	3-phosphoinositide-dependent protein kinase 1	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00059	p53 pathway	G04694	p110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01188	Gbetagamma	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01171	PLCgamma	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=97614|UniProtKB=Q8R3B1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	12860966	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00029	Huntington disease	P00774	Dynein complex	XENTR|Xenbase=XB-GENE-490205|UniProtKB=F6QEI9	Uncharacterized protein	ISS	9454836	PubMed	PTHR12688:SF2	CYTOPLASMIC DYNEIN 1 LIGHT INTERMEDIATE CHAIN 1
P00005	Angiogenesis	P00189	Fzd	BOVIN|Ensembl=ENSBTAG00000020957|UniProtKB=F1MGM1	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF126	FRIZZLED-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	MONDO|Ensembl=ENSMODG00000005317|UniProtKB=F7D2P3	Uncharacterized protein	ISS	12888804	PubMed	PTHR43940:SF4	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT DELTA
P00057	Wnt signaling pathway	P01451	Galpha	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04393	Ras Pathway	P04567	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IDA	10799299	PubMed	PTHR10048:SF14	PI-3 KINASE
P00050	Plasminogen activating cascade	P01250	MMP-13	HUMAN|HGNC=7159|UniProtKB=P45452	Collagenase 3	IDA	8207000	PubMed	PTHR10201:SF165	COLLAGENASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00087	Fe65	RAT|RGD=2122|UniProtKB=P46933	Amyloid beta A4 precursor protein-binding family B member 1	IDA	11441186	PubMed	PTHR14058:SF5	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1
P00048	PI3 kinase pathway	P01189	PTEN	CAEEL|WormBase=WBGene00000913|UniProtKB=G5EE01	DAF-18	TAS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	BRAFL|Gene=BRAFLDRAFT_215305|UniProtKB=C3YPV2	Putative uncharacterized protein (Fragment)	ISS	5031595	gi	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00029	Huntington disease	P00775	Rac	CAEEL|WormBase=WBGene00003239|UniProtKB=G5EBV3	Rac-like GTPase	TAS			PTHR24072:SF157	AT17867P
P00053	T cell activation	P01300	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00006	Apoptosis signaling pathway	P00269	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04407	K+ channel	CHICK|Ensembl=ENSGALG00000016193|UniProtKB=E1BYI0	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00048	PI3 kinase pathway	P01194	S6K	PANTR|Ensembl=ENSPTRG00000009477|UniProtKB=H2QDK7	Ribosomal protein S6 kinase	ISS	15116068	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00807	Actin	PANTR|Ensembl=ENSPTRG00000011990|UniProtKB=H2QHZ9	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04392	P53 pathway feedback loops 1	G04685	p73DeltaN	BOVIN|Ensembl=ENSBTAG00000015460|UniProtKB=F1MKA9	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00010	B cell activation	P00391	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00636	FGFR1-4	MONDO|Ensembl=ENSMODG00000008525|UniProtKB=F7DHF8	Fibroblast growth factor receptor	ISS	10626794	PubMed	PTHR24416:SF130	FIBROBLAST GROWTH FACTOR RECEPTOR 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	3045562	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00005	Angiogenesis	P00230	PDGFR	RAT|RGD=3284|UniProtKB=P20786	Platelet-derived growth factor receptor alpha	ISS	12374780	PubMed	PTHR24416:SF52	PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DANRE|ZFIN=ZDB-GENE-040426-1178|UniProtKB=Q7SY24	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00010	B cell activation	P00398	IP3R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00052	TGF-beta signaling pathway	P01275	P38	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	8920915	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00029	Huntington disease	P00775	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	SCHPO|PomBase=SPAC1F3.06c|UniProtKB=Q10411	Sporulation-specific protein 15	IC			PTHR13140:SF667	MYOSIN-J HEAVY CHAIN
P00057	Wnt signaling pathway	P01458	Protein Kinase C	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	IDA	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04371	5-Hydroxytryptamine biosynthesis	P04400	Aromatic L-amino acid decarboxylase	CAEEL|WormBase=WBGene00015467|UniProtKB=O45138	BAS-Like	ISS	7567987	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00021	FGF signaling pathway	P00648	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	PANTR|Ensembl=ENSPTRG00000017635|UniProtKB=H2QS64	Uncharacterized protein	ISS			PTHR10937:SF10	GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE  ISOMERIZING  2
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MACMU|Ensembl=ENSMMUG00000001661|UniProtKB=F7GR69	Uncharacterized protein	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00006	Apoptosis signaling pathway	P00310	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00563	Gab	HUMAN|HGNC=4066|UniProtKB=Q13480	GRB2-associated-binding protein 1	IGI	4503851	gi	PTHR12156:SF18	GRB2-ASSOCIATED-BINDING PROTEIN 1
P02747	Histidine biosynthesis	P02992	Imidazol glycerol phosphate synthase	DEIRA|EnsemblGenome=DR_0426|UniProtKB=Q9RX89	Imidazole glycerol phosphate synthase subunit HisH	ISS			PTHR42701:SF1	IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISH
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	MOUSE|MGI=MGI=109521|UniProtKB=P35363	5-hydroxytryptamine receptor 2A	ISS	11859080	PubMed	PTHR24247:SF30	5-HYDROXYTRYPTAMINE RECEPTOR 2A
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	7925653	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000024633|UniProtKB=F1MBU9	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00702	CPB	BOVIN|Ensembl=ENSBTAG00000011429|UniProtKB=Q8SQ19	Cyclic AMP-responsive element-binding protein 3	IDA			PTHR22952:SF100	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	ORNAN|Ensembl=ENSOANG00000002061|UniProtKB=F7ANC6	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00005	Angiogenesis	P00190	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	11847220	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000023940|UniProtKB=F6RFW8	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2522|UniProtKB=P30729	D(4) dopamine receptor	IDA	2137198	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00017	DNA replication	P00535	5' to 3' Exoribonulcease	MOUSE|MGI=MGI=894687|UniProtKB=Q9DBR1	5'-3' exoribonuclease 2	ISS	7885830	PubMed	PTHR12341:SF41	5'-3' EXORIBONUCLEASE 2
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	CANLF|Ensembl=ENSCAFG00000003409|UniProtKB=E2R7H9	Uncharacterized protein	ISS			PTHR23409:SF20	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00059	p53 pathway	G01579	PTEN	DICDI|dictyBase=DDB_G0286557|UniProtKB=Q8T9S7	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI			PTHR12305:SF79	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00059	p53 pathway	G04703	Apaf	MACMU|Ensembl=ENSMMUG00000022404|UniProtKB=F6U0K7	Apoptotic protease-activating factor 1	ISS	10364241	PubMed	PTHR22845:SF5	APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
P00047	PDGF signaling pathway	P01162	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00029	Huntington disease	P00807	Actin	TRIVA|Gene=TVAG_512800|UniProtKB=A2HNG1	Actin (Fragment)	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	CHICK|Ensembl=ENSGALG00000002003|UniProtKB=F1P3H0	Receptor protein serine/threonine kinase	TAS	10683140	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00056	VEGF signaling pathway	P01407	Erk	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04580	TRH Receptor	MOUSE|MGI=MGI=98824|UniProtKB=P21761	Thyrotropin-releasing hormone receptor	ISS	7509436	PubMed	PTHR24243:SF115	THYROTROPIN-RELEASING HORMONE RECEPTOR
P00049	Parkinson disease	P01219	SAPK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00203	Erk	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05731	GABA-B receptor II signaling	P05758	K channel	MACMU|Ensembl=ENSMMUG00000007096|UniProtKB=F7ERG6	G protein-activated inward rectifier potassium channel 1	ISS	2433589	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00645	Rac	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00029	Huntington disease	P00788	Calpain	PANTR|Ensembl=ENSPTRG00000003869|UniProtKB=H2Q425	Uncharacterized protein	ISS	11675509	PubMed	PTHR10183:SF284	CALPAIN-1 CATALYTIC SUBUNIT
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02748	Isoleucine biosynthesis	P02996	Ketol-acid reductoisomerase	METAC|EnsemblGenome=MA_3790|UniProtKB=Q8TJJ4	Ketol-acid reductoisomerase	ISS			PTHR21371:SF1	KETOL-ACID REDUCTOISOMERASE, CHLOROPLASTIC
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IGI	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00005	Angiogenesis	P00206	Wnt	PANTR|Ensembl=ENSPTRG00000015034|UniProtKB=H2QMT4	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	TAKRU|Ensembl=ENSTRUG00000015213|UniProtKB=H2UPJ1	Uncharacterized protein	ISS	20112749	PubMed	PTHR18966:SF356	SUBFAMILY NOT NAMED
P02750	Lipoate_biosynthesis	P03004	Lipoate synthase	SYNY3|EnsemblGenome=BAA17612|UniProtKB=P73572	Lipoyl synthase 2	ISS			PTHR10949:SF0	LIPOYL SYNTHASE, MITOCHONDRIAL
P02738	De novo purine biosynthesis	P02909	GDP reductase	MACMU|Ensembl=ENSMMUG00000003962|UniProtKB=F6Z9D7	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	DANRE|ZFIN=ZDB-GENE-030131-9662|UniProtKB=Q6TEN1	Ras-related protein Rap-1b	ISS	1904317	PubMed	PTHR24070:SF382	RAS-RELATED PROTEIN RAP-1B
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	PUCGT|EnsemblGenome=PGTG_05488|UniProtKB=E3K4I1	Actin	IC	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IC	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00046	Oxidative stress response	P01135	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	RAT|RGD=621516|UniProtKB=G3V6P8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	RAT|RGD=735101|UniProtKB=Q6P9T8	Tubulin beta-4B chain	ISS	12932731	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IDA	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00053	T cell activation	P01332	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	BOVIN|Gene=MYH7|UniProtKB=Q9BE39	Myosin-7	IC	10938134	PubMed	PTHR13140:SF344	MYOSIN-7
P00034	Integrin signalling pathway	P00944	Actin	CANLF|Ensembl=ENSCAFG00000016020|UniProtKB=O18840	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00053	T cell activation	P01300	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9836512	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00045	Notch signaling pathway	P01114	Ntm	BOVIN|Ensembl=ENSBTAG00000007909|UniProtKB=F1MPE9	Uncharacterized protein	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02762	Pentose phosphate pathway	P03071	Ribulose 5-P Isomerase	DROME|FlyBase=FBgn0050410|UniProtKB=Q8MLS2	Ribose-5-phosphate isomerase, isoform B	RCA			PTHR11934:SF0	RIBOSE-5-PHOSPHATE ISOMERASE
P05915	Opioid proenkephalin pathway	P05994	G-protein	CHICK|Ensembl=ENSGALG00000027629|UniProtKB=Q5ZJ03	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00024	Glycolysis	P00671	Phosphoglycerate kinase	BACSU|EnsemblGenome=BSU33930|UniProtKB=P40924	Phosphoglycerate kinase	ISS	98044033	PubMed	PTHR11406:SF0	PHOSPHOGLYCERATE KINASE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	IC	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00059	p53 pathway	P01482	ARF	HUMAN|HGNC=1790|UniProtKB=P55273	Cyclin-dependent kinase 4 inhibitor D	ISS			PTHR24148:SF47	CYCLIN-DEPENDENT KINASE 4 INHIBITOR B-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	TAS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	TAS	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00060	Ubiquitin proteasome pathway	P01491	E2	XENTR|Xenbase=XB-GENE-949494|UniProtKB=F6Y655	Uncharacterized protein (Fragment)	ISS			PTHR24067:SF3	UBIQUITIN-CONJUGATING ENZYME E2 G1
P00054	Toll receptor signaling pathway	P01356	ERK2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9836512	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04395	Vasopressin synthesis	P04597	Signal Peptide	PANTR|Ensembl=ENSPTRG00000013189|UniProtKB=H2QJV1	Uncharacterized protein	ISS	6717565	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00018	EGF receptor signaling pathway	P00549	EGF	RAT|RGD=1303302|UniProtKB=O35569	Pro-neuregulin-2, membrane-bound isoform	RCA			PTHR11100:SF20	PRO-NEUREGULIN-2, MEMBRANE-BOUND ISOFORM-RELATED
P00048	PI3 kinase pathway	P01190	PDK1 ACT	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00048	PI3 kinase pathway	P01188	Gbetagamma	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00048	PI3 kinase pathway	P01199	Galpha	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	SCHPO|PomBase=SPBC32H8.07|UniProtKB=Q10282	Guanine nucleotide-binding protein subunit beta	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00005	Angiogenesis	P00221	JNK1	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	ISS	7600581	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00029	Huntington disease	P00807	Actin	BOVIN|Gene=ACTR2|UniProtKB=A7MB62	Actin-related protein 2	ISS	11889126	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00049	Parkinson disease	P01208	Hsp70	DANRE|ZFIN=ZDB-GENE-021209-1|UniProtKB=F1QK71	DNA helicase	IDA			PTHR11630:SF42	DNA REPLICATION LICENSING FACTOR MCM5
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00057	Wnt signaling pathway	P01443	Phospholipase C	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00005	Angiogenesis	P00203	Erk	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04372	5-Hydroxytryptamine degredation	P04401	Monoamine Oxidase	SYNY3|EnsemblGenome=BAA10142|UniProtKB=Q55629	Uncharacterized protein slr0782	ISS			PTHR43563:SF2	AMINE OXIDASE  FLAVIN-CONTAINING
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	BOVIN|Ensembl=ENSBTAG00000012687|UniProtKB=F1MV64	Tyrosine-protein kinase receptor	ISS	249616	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02757	O-antigen biosynthesis	P03050	dTDP-4-dehydrorhamnose reductase	PANTR|Ensembl=ENSPTRG00000017504|UniProtKB=G2HHR9	Methionine adenosyltransferase II, beta	ISS			PTHR10491:SF4	METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	DEIRA|EnsemblGenome=DR_0451|UniProtKB=Q9RX64	Glutamine synthase	ISS			PTHR43785:SF1	TYPE-1 GLUTAMINE SYNTHETASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Ensembl=ENSBTAG00000001067|UniProtKB=E1BAB4	Uncharacterized protein	ISS	20012997	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00010	B cell activation	P00367	NFAT	RAT|RGD=1307690|UniProtKB=D4A0I8	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (Predicted), isoform CRA_b	ISS	12787506	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	IC	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	TAS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00010	B cell activation	P00372	Grb2	HUMAN|HGNC=4566|UniProtKB=P62993	Growth factor receptor-bound protein 2	RCA			PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	TAS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	8687401	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00029	Huntington disease	P00807	Actin	ORYSJ|EnsemblGenome=OS10G0510000|UniProtKB=A3C6D7	Actin-2	IDA	10974003	PubMed	PTHR11937:SF252	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	P01457	GBeta	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00053	T cell activation	P01320	PLC-gamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P02738	De novo purine biosynthesis	P02907	dADP kinase	PSEAE|EnsemblGenome=PA3807|UniProtKB=Q59636	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	YEAST|SGD=S000001649|UniProtKB=P05986	cAMP-dependent protein kinase type 3	ISS	89107990	PubMed	PTHR24353:SF73	CAMP-DEPENDENT PROTEIN KINASE TYPE 1-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00007	Axon guidance mediated by semaphorins	P00340	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04395	Vasopressin synthesis	P04589	Signal Peptidase	CAEBR|Gene=CBG04194|UniProtKB=A8WWE1	Signal peptidase complex catalytic subunit SEC11	ISS	2674115	PubMed	PTHR10806:SF6	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06786	ERK1/2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	RCA	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=88396|UniProtKB=P12657	Muscarinic acetylcholine receptor M1	IDA			PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00004	Alzheimer disease-presenilin pathway	P00145	CD44	HUMAN|HGNC=1681|UniProtKB=P16070	CD44 antigen	IDA	14871815	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P00005	Angiogenesis	P00230	PDGFR	MACMU|Ensembl=ENSMMUG00000015707|UniProtKB=F6SLY4	Platelet-derived growth factor receptor alpha	ISS	12374780	PubMed	PTHR24416:SF52	PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA
P00018	EGF receptor signaling pathway	P00562	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	ISS	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00015	Circadian clock system	P00505	Cry	ARATH|TAIR=AT2G47590|UniProtKB=Q8LB72	Blue-light photoreceptor PHR2	ISS			PTHR11455:SF2	BLUE-LIGHT PHOTORECEPTOR PHR2
P00021	FGF signaling pathway	P00627	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00034	Integrin signalling pathway	P00925	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IDA	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	DAPPU|EnsemblGenome=DAPPUDRAFT_305830|UniProtKB=E9GTE8	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MACMU|Ensembl=ENSMMUG00000020134|UniProtKB=F6U055	Uncharacterized protein	ISS	12356903	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00029	Huntington disease	P00790	beta-Tubulin	SCHMA|EnsemblGenome=Smp_079960|UniProtKB=G4VTA4	Putative tubulin beta chain	ISS	12932731	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	DANRE|ZFIN=ZDB-GENE-040625-181|UniProtKB=Q6IQV0	Uncharacterized protein	ISS	10806215	PubMed	PTHR24054:SF28	CASEIN KINASE 2 ALPHA 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000010526|UniProtKB=F7B1S0	Uncharacterized protein	ISS			PTHR11824:SF7	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00049	Parkinson disease	P01211	ERK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	IDA	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05734	Synaptic vesicle trafficking	P05780	Rab3A	CANLF|Ensembl=ENSCAFG00000014945|UniProtKB=E2RIA5	Uncharacterized protein	ISS	9194562	PubMed	PTHR24073:SF532	RAS-RELATED PROTEIN RAB-3A
P00047	PDGF signaling pathway	P01155	Jak	HUMAN|HGNC=6190|UniProtKB=P23458	Tyrosine-protein kinase JAK1	ISS	9637709	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00021	FGF signaling pathway	P00633	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00005	Angiogenesis	P00190	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	88318957	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00906	Rap1	BOVIN|Ensembl=ENSBTAG00000018239|UniProtKB=A5D7F5	DnaJ homolog subfamily C member 27	ISS			PTHR24073:SF269	DNAJ HOMOLOG SUBFAMILY C MEMBER 27
P02746	Heme biosynthesis	P02981	Glutamate-1-semialdehyde aminotransferase	HALSA|EnsemblGenome=VNG_2326G|UniProtKB=Q9HMY8	Glutamate-1-semialdehyde 2,1-aminomutase	ISS			PTHR43713:SF3	GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01067	AChE	DANRE|ZFIN=ZDB-GENE-010906-1|UniProtKB=Q9DDE3	Acetylcholinesterase	ISS	86008285	PubMed	PTHR43918:SF3	ACETYLCHOLINESTERASE
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00641	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00059	p53 pathway	P04630	PP2A	RAT|RGD=3380|UniProtKB=P63331	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00627	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	12657601	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00047	PDGF signaling pathway	P01159	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00015	Circadian clock system	P00505	Cry	MOUSE|MGI=MGI=1270859|UniProtKB=Q9R194	Cryptochrome-2	IDA	10217146	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00012	Cadherin signaling pathway	P00474	Wnt	XENTR|Xenbase=XB-GENE-484098|UniProtKB=F6ZQ88	Protein Wnt (Fragment)	ISS	8717036	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P05731	GABA-B receptor II signaling	P05755	Gbeta	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00053	T cell activation	P01336	Jnk	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00021	FGF signaling pathway	P00640	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	RAT|RGD=2028|UniProtKB=P38445	Activin receptor type-2B	TAS	11252892	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00034	Integrin signalling pathway	P00907	ERK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	ISS			PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00049	Parkinson disease	P01211	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00787	MAPKK4	MONDO|Ensembl=ENSMODG00000008266|UniProtKB=F6Z879	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00018	EGF receptor signaling pathway	P00543	ERK1-2	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	PANTR|Ensembl=ENSPTRG00000006890|UniProtKB=H2Q943	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P02784	Tyrosine biosynthesis	P03214	Prephenate dehydrogenase	GLOVI|Gene=BAC88347|UniProtKB=Q7NNK5	Prephenate dehydrogenase	ISS			PTHR21363:SF0	PREPHENATE DEHYDROGENASE  NADP +
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IDA	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00872	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	RCA			PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	BOVIN|Ensembl=ENSBTAG00000008026|UniProtKB=P01175	Oxytocin-neurophysin 1	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P04393	Ras Pathway	P04546	GSK3	DICDI|dictyBase=DDB_G0272110|UniProtKB=P51136	Glycogen synthase kinase-3	IDA	21361340	gi	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IDA	10395542	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P02742	Tetrahydrofolate biosynthesis	P02951	GTP cyclohydrolase	PSEAE|EnsemblGenome=PA1674|UniProtKB=Q9I351	GTP cyclohydrolase 1 2	ISS			PTHR11109:SF0	GTP CYCLOHYDROLASE 1
P00022	General transcription by RNA polymerase I	P00652	RNA Polymerase I  Complex	MOUSE|MGI=MGI=108014|UniProtKB=P70700	DNA-directed RNA polymerase I subunit RPA2	ISS	15691654	PubMed	PTHR20856:SF5	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA2
P00007	Axon guidance mediated by semaphorins	P00334	PlexinA1	HUMAN|HGNC=9099|UniProtKB=Q9UIW2	Plexin-A1	IDA	10520995	PubMed	PTHR22625:SF35	PLEXIN-A1
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00029	Huntington disease	P00807	Actin	XENTR|Xenbase=XB-GENE-491618|UniProtKB=Q6P378	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IC	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00046	Oxidative stress response	P01135	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00053	T cell activation	P01319	PAK	HUMAN|HGNC=8590|UniProtKB=Q13153	Serine/threonine-protein kinase PAK 1	IDA	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00589	Akt	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	IGI	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01292	RSmads	ORNAN|Ensembl=ENSOANG00000001971|UniProtKB=F6UPF6	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF42	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 2
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=2136756|UniProtKB=Q91Y02	Protocadherin beta-18	IDA	8120095	PubMed	PTHR24028:SF54	PROTOCADHERIN BETA-10
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00006	Apoptosis signaling pathway	P00274	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00056	VEGF signaling pathway	P01423	p38MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00587	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MOUSE|MGI=MGI=109563|UniProtKB=P70658	C-X-C chemokine receptor type 4	ISS	4503175	gi	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P00021	FGF signaling pathway	P00640	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	G01543	IGFBP1	RAT|RGD=2872|UniProtKB=P21743	Insulin-like growth factor-binding protein 1	ISS			PTHR11551:SF6	INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 1
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MACMU|Ensembl=ENSMMUG00000007768|UniProtKB=F7CW00	Homeobox protein engrailed-like	ISS	12356903	PubMed	PTHR24341:SF5	HOMEOBOX PROTEIN ENGRAILED-2
P00048	PI3 kinase pathway	P01177	P110ACT	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00521	Profilin	MACMU|Ensembl=ENSMMUG00000002772|UniProtKB=F7H2A5	Profilin	ISS			PTHR13936:SF14	PROFILIN-1
P00019	Endothelin signaling pathway	P00577	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00057	Wnt signaling pathway	P01457	GBeta	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IDA	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014555|UniProtKB=F7GT55	Syntaxin-1A isoform 1	ISS	1321498	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	15572354	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00005	Angiogenesis	P00256	PLC-gamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00046	Oxidative stress response	P01131	MKP5	RAT|RGD=70978|UniProtKB=Q64346	Dual specificity protein phosphatase 6	TAS			PTHR10159:SF45	DUAL SPECIFICITY PROTEIN PHOSPHATASE 6
P05918	p38 MAPK pathway	P06020	p38delta	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	RCA	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00047	PDGF signaling pathway	P01154	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00056	VEGF signaling pathway	P01422	eNOS	MACMU|Ensembl=ENSMMUG00000020437|UniProtKB=F6WEB2	Nitric oxide synthase	ISS	22462730	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00059	p53 pathway	P01480	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	IGI	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00057	Wnt signaling pathway	P01443	Phospholipase C	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00046	Oxidative stress response	P01129	JNK1/2	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00645	Rac	ENTHI|EnsemblGenome=EHI_129750|UniProtKB=C4M5Q7	Rho family GTPase	IGI	12932731	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00054	Toll receptor signaling pathway	P01341	Elk1	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	ISS	3183861	gi	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DANRE|ZFIN=ZDB-GENE-050417-267|UniProtKB=F1QUN8	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF263	ACTIN
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00211	GSK3beta	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MACMU|Ensembl=ENSMMUG00000007765|UniProtKB=F7CW57	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00036	Interleukin signaling pathway	P00975	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	14707121	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	BACSU|EnsemblGenome=BSU22730|UniProtKB=P31103	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHICK|Ensembl=ENSGALG00000011086|UniProtKB=P68139	Actin, alpha skeletal muscle	ISS	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P02738	De novo purine biosynthesis	P02909	GDP reductase	MOUSE|MGI=MGI=2155865|UniProtKB=Q6PEE3	Ribonucleoside-diphosphate reductase subunit M2 B	ISS			PTHR23409:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 B
P00036	Interleukin signaling pathway	P00981	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	MACMU|Ensembl=ENSMMUG00000015240|UniProtKB=F6VUY3	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	MACMU|Ensembl=ENSMMUG00000009679|UniProtKB=F6YBQ8	Uncharacterized protein	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00021	FGF signaling pathway	P00627	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	20216076	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04573	Elk-1	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	11279280	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00037	Ionotropic glutamate receptor pathway	P01018	Glu1	CAEEL|WormBase=WBGene00001612|UniProtKB=P34299	Glutamate receptor 1	ISS	12941441	PubMed	PTHR18966:SF297	GLUTAMATE RECEPTOR 1
P00011	Blood coagulation	P00422	FIXa	MACMU|Ensembl=ENSMMUG00000020064|UniProtKB=F7GHR4	Uncharacterized protein	ISS	14270099	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00640	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12880387	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00012	Cadherin signaling pathway	P00470	F-actin	PHYIT|EnsemblGenome=PITG_15117|UniProtKB=D0NRP9	Actin-like protein	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	IDA	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00011	Blood coagulation	P00460	FXI	HUMAN|HGNC=3551|UniProtKB=P00740	Coagulation factor IX	ISS	14270099	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00965	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00034	Integrin signalling pathway	P00925	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	RAT|RGD=1305515|UniProtKB=F1M0G0	Protein Rgs17	ISS	21240406	PubMed	PTHR10845:SF196	REGULATOR OF G-PROTEIN SIGNALING 17
P04396	Vitamin D metabolism and pathway	P04606	VDR	BOVIN|Gene=VDR|UniProtKB=Q28037	Vitamin D3 receptor	ISS	11705326	PubMed	PTHR24082:SF38	VITAMIN D3 RECEPTOR
P00020	FAS signaling pathway	P00616	Nuclear Lamin	HUMAN|HGNC=6638|UniProtKB=Q03252	Lamin-B2	TAS	11165516	PubMed	PTHR23239:SF152	LAMIN-B2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P05918	p38 MAPK pathway	P06039	MSK2	HUMAN|HGNC=10433|UniProtKB=O75676	Ribosomal protein S6 kinase alpha-4	RCA	9792677	PubMed	PTHR24351:SF41	RIBOSOMAL PROTEIN S6 KINASE ALPHA-4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01098	CHT1	MOUSE|MGI=MGI=2147834|UniProtKB=Q8VBW1	Sodium- and chloride-dependent creatine transporter 1	ISS			PTHR11616:SF96	SODIUM- AND CHLORIDE-DEPENDENT CREATINE TRANSPORTER 1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	SCHPO|PomBase=SPCC191.02c|UniProtKB=P78773	Probable acetyl-coenzyme A synthetase	ISS			PTHR24095:SF14	ACETYL-COENZYME A SYNTHETASE 1
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CAEEL|WormBase=WBGene00001612|UniProtKB=P34299	Glutamate receptor 1	IC	8804111	PubMed	PTHR18966:SF297	GLUTAMATE RECEPTOR 1
P00056	VEGF signaling pathway	P01417	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01438	PP2A	CHICK|Ensembl=ENSGALG00000009828|UniProtKB=E1C5A3	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00049	Parkinson disease	P01238	14-3-3	MOUSE|MGI=MGI=1891917|UniProtKB=Q9CQV8	14-3-3 protein beta/alpha	ISS	91108808	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DROME|FlyBase=FBgn0000047|UniProtKB=P83967	Actin, indirect flight muscle	IC	10974003	PubMed	PTHR11937:SF368	ACTIN, INDIRECT FLIGHT MUSCLE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	MOUSE|MGI=MGI=88398|UniProtKB=Q9ERZ3	Muscarinic acetylcholine receptor M3	ISS	10069496	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PHYPA|Gene=PHYPADRAFT_107830|UniProtKB=A9TBG2	Actin 7	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05916	Opioid prodynorphin pathway	P06002	G-protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	ISS	11535291	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IDA	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	XENTR|Ensembl=ENSXETG00000021375|UniProtKB=F6T423	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P05913	Enkephalin release	P05978	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	MACMU|Ensembl=ENSMMUG00000012470|UniProtKB=F7G0B2	Uncharacterized protein	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00049	Parkinson disease	P01231	gamma-Synuclein	MOUSE|MGI=MGI=1298397|UniProtKB=Q9Z0F7	Gamma-synuclein	NAS			PTHR13820:SF10	GAMMA-SYNUCLEIN
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	G01574	ARF	PANTR|Ensembl=ENSPTRG00000020827|UniProtKB=H2QX30	Uncharacterized protein	ISS	12082609	PubMed	PTHR24148:SF47	CYCLIN-DEPENDENT KINASE 4 INHIBITOR B-RELATED
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	TAS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00019	Endothelin signaling pathway	P00586	Gq	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00645	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	IPI	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05915	Opioid proenkephalin pathway	P05994	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00004	Alzheimer disease-presenilin pathway	P00127	APP	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P06959	CCKR signaling map	P07083	SHC1 @EGFR	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	RCA	9544989	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06768	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	RCA	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P02785	Valine biosynthesis	P03215	Branched chain amino acid aminotransferase	STRCO|EnsemblGenome=CAA19971|UniProtKB=O86505	Probable branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF44	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P00053	T cell activation	P01307	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00022	General transcription by RNA polymerase I	P00652	RNA Polymerase I  Complex	PANTR|Ensembl=ENSPTRG00000005734|UniProtKB=H2RA83	Polymerase (RNA) I polypeptide D, 16kDa	ISS	12446911	PubMed	PTHR13946:SF28	DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	BOVIN|Ensembl=ENSBTAG00000003762|UniProtKB=A5PJS1	GNB5 protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05913	Enkephalin release	G06045	preproenkephalin	XENTR|Xenbase=XB-GENE-942760|UniProtKB=F6Y5F6	Uncharacterized protein	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00004	Alzheimer disease-presenilin pathway	P00114	actin	USTMA|Gene=UMAG_11232|UniProtKB=A0A0D1DMT3	Chromosome 22, whole genome shotgun sequence	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	DROME|FlyBase=FBgn0013759|UniProtKB=Q24210	Peripheral plasma membrane protein CASK	ISS	11679592	PubMed	PTHR23122:SF7	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00471	Cadherin	BOVIN|Ensembl=ENSBTAG00000037844|UniProtKB=Q08DJ5	Cadherin-18	ISS	8120095	PubMed	PTHR24027:SF106	CADHERIN-18
P00023	General transcription regulation	P00662	TFIIA complex	MOUSE|MGI=MGI=1933277|UniProtKB=Q99PM3	Transcription initiation factor IIA subunit 1	ISS	600519	OMIM	PTHR12694:SF7	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1
P00046	Oxidative stress response	P01135	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00009	Axon guidance mediated by netrin	P00366	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00907	ERK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS			PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04384	Gamma-aminobutyric acid synthesis	P04482	Glutamate decarboxylase	CAEBR|Gene=CBG15755|UniProtKB=A8XMQ1	Protein CBR-UNC-25	ISS	2247446	PubMed	PTHR11999:SF137	GLUTAMATE DECARBOXYLASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02738	De novo purine biosynthesis	P02907	dADP kinase	RAT|RGD=619879|UniProtKB=G3V816	Nucleoside diphosphate kinase	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P00006	Apoptosis signaling pathway	P00318	PKCs	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01322	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IGI	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MOUSE|MGI=MGI=1923151|UniProtKB=Q91YD3	mRNA-decapping enzyme 1A	TAS	12809600	PubMed	PTHR16290:SF4	MRNA-DECAPPING ENZYME 1A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	MOUSE|MGI=MGI=88296|UniProtKB=O55017	Voltage-dependent N-type calcium channel subunit alpha-1B	IDA	8386525	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	MOUSE|MGI=MGI=95811|UniProtKB=Q9Z2W8	Glutamate receptor 4	ISS	12497607	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P05913	Enkephalin release	P05974	G-Protein (i)	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	IC	11535291	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00020	FAS signaling pathway	P00615	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00059	p53 pathway	P04633	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_56687|UniProtKB=C3YC50	Putative uncharacterized protein	IDA	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00224	PDGF	PANTR|Ensembl=ENSPTRG00000014392|UniProtKB=H2QLQ2	Uncharacterized protein	ISS			PTHR11633:SF2	PLATELET-DERIVED GROWTH FACTOR SUBUNIT B
P00019	Endothelin signaling pathway	P00580	ET-RA/B	MOUSE|MGI=MGI=105923|UniProtKB=Q61614	Endothelin-1 receptor	ISS	8564193	PubMed	PTHR24243:SF31	ENDOTHELIN-1 RECEPTOR
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12805548	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	BOVIN|Ensembl=ENSBTAG00000007909|UniProtKB=F1MPE9	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00047	PDGF signaling pathway	P01161	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	HALSA|EnsemblGenome=VNG_0315G|UniProtKB=Q9HSB3	Transcription initiation factor IIB 6	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	PLAF7|EnsemblGenome=PFL1720w|UniProtKB=Q8I566	Serine hydroxymethyltransferase	ISS			PTHR11680:SF28	SERINE HYDROXYMETHYLTRANSFERASE 1
P00021	FGF signaling pathway	P00644	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	ISS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	BOVIN|Ensembl=ENSBTAG00000000219|UniProtKB=F1MCL3	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	TAS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	HUMAN|HGNC=9855|UniProtKB=P62834	Ras-related protein Rap-1A	IDA	10476970	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MOUSE|MGI=MGI=107848|UniProtKB=Q9D6F9	Tubulin beta-4A chain	ISS	9454836	PubMed	PTHR11588:SF253	TUBULIN BETA-4A CHAIN
P00059	p53 pathway	P04616	PDK1/2	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	TAS	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00004	Alzheimer disease-presenilin pathway	P00144	Ire-1	ARATH|TAIR=AT3G11870|UniProtKB=Q9SF12	Inactive serine/threonine-protein kinase/endoribonuclease IRE1-like	IDA	10619423	PubMed	PTHR13954:SF6	INOSITOL-REQUIRING ENZYME-1
P02751	Lysine biosynthesis	P03013	Aspartate semialdehyde dehydrogenase	THEMA|EnsemblGenome=TM_1523|UniProtKB=Q9X1L1	Aspartate-semialdehyde dehydrogenase	ISS			PTHR10174:SF2	ASPARTATE-SEMIALDEHYDE DEHYDROGENASE
P00034	Integrin signalling pathway	P00912	Arp2/3	PANTR|Ensembl=ENSPTRG00000005438|UniProtKB=H2RBJ1	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00025	Hedgehog signaling pathway	P00685	Smoothened	HUMAN|HGNC=11119|UniProtKB=Q99835	Smoothened homolog	IDA	942251	PubMed	PTHR11309:SF35	SMOOTHENED HOMOLOG
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	TAS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01375	JNK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	ISS	10207617	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	SCHPO|PomBase=SPAC9G1.02|UniProtKB=O14299	MAP kinase kinase kinase wis4	ISS			PTHR24361:SF651	STE20-RELATED KINASE ADAPTER PROTEIN STRD-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	BOVIN|Ensembl=ENSBTAG00000047719|UniProtKB=Q95136	D(1A) dopamine receptor	ISS	15328036	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	CANLF|Ensembl=ENSCAFG00000016020|UniProtKB=O18840	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P02723	Adenine and hypoxanthine salvage pathway	P02809	Xanthine dehydrogenase	DROME|FlyBase=FBgn0003308|UniProtKB=P10351	Xanthine dehydrogenase	ISS	2493563	PubMed	PTHR11908:SF100	XANTHINE DEHYDROGENASE
P00057	Wnt signaling pathway	P01443	Phospholipase C	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00920	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00006	Apoptosis signaling pathway	P00260	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01153	GSK3	ARATH|TAIR=AT1G57870|UniProtKB=Q9FVS6	Shaggy-related protein kinase delta	ISS	21361340	gi	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00509	Slingshot	MOUSE|MGI=MGI=2683546|UniProtKB=Q8K330	Protein phosphatase Slingshot homolog 3	ISS			PTHR10159:SF349	PROTEIN PHOSPHATASE SLINGSHOT HOMOLOG 3
P04393	Ras Pathway	P04578	Rho	BOVIN|Ensembl=ENSBTAG00000004279|UniProtKB=P61585	Transforming protein RhoA	ISS	12169092	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	PANTR|Gene=CHRNA4|UniProtKB=Q5IS77	Neuronal acetylcholine receptor subunit alpha-4	ISS	17597586	PubMed	PTHR18945:SF401	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00046	Oxidative stress response	P01135	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	12810719	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00047	PDGF signaling pathway	P01159	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P02779	Thiamin biosynthesis	P03170	Hydroxymethylpyrimidine phosphate kinase	LEPIN|EnsemblGenome=LA_0130|UniProtKB=Q8F9R1	Phosphomethylpyrimidine kinase protein	ISS			PTHR20858:SF17	HYDROXYMETHYLPYRIMIDINE/PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00022	General transcription by RNA polymerase I	P00651	TAF-IA	HUMAN|HGNC=11532|UniProtKB=Q15573	TATA box-binding protein-associated factor RNA polymerase I subunit A	IGI	10894955	PubMed	PTHR32122:SF1	TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00054	Toll receptor signaling pathway	P01368	MKK2	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	MONDO|Ensembl=ENSMODG00000005864|UniProtKB=F6T425	Uncharacterized protein	ISS			PTHR11482:SF7	ANTIZYME INHIBITOR 1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	PSEAE|EnsemblGenome=PA1155|UniProtKB=Q9I4I2	Ribonucleoside-diphosphate reductase subunit beta	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02723	Adenine and hypoxanthine salvage pathway	P02804	Hypoxanthine phosphoribosyl transferase	PLAF7|EnsemblGenome=PF10_0121|UniProtKB=Q8IJS1	Hypoxanthine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00046	Oxidative stress response	P01129	JNK1/2	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02738	De novo purine biosynthesis	P02902	ADP reductase	HUMAN|HGNC=10452|UniProtKB=P31350	Ribonucleoside-diphosphate reductase subunit M2	ISS			PTHR23409:SF20	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00786	ARF	XENTR|Xenbase=XB-GENE-952628|UniProtKB=B0JZE7	LOC100145191 protein	ISS	12932731	PubMed	PTHR11711:SF234	ADP-RIBOSYLATION FACTOR 1
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	MACMU|Ensembl=ENSMMUG00000018375|UniProtKB=F7H1D5	Neurogenic locus notch homolog protein 2 isoform 1 preproprotein	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00010	B cell activation	P00373	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	11956331	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	MOUSE|MGI=MGI=1298218|UniProtKB=O88572	Low-density lipoprotein receptor-related protein 6	IDA	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00012	Cadherin signaling pathway	P00470	F-actin	ARATH|TAIR=AT2G42100|UniProtKB=Q8RYC2	Putative actin-5	IC	11889126	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	RCA			PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00029	Huntington disease	P00807	Actin	DANRE|ZFIN=ZDB-GENE-050410-4|UniProtKB=Q56A35	Actin-related protein 2-B	ISS	11889126	PubMed	PTHR11937:SF149	ACTIN-RELATED PROTEIN 2-A-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01187	IR	HUMAN|HGNC=6091|UniProtKB=P06213	Insulin receptor	ISS	2983222	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P04393	Ras Pathway	P04572	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	IC	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00049	Parkinson disease	P01238	14-3-3	ORYSJ|EnsemblGenome=OS03G0710800|UniProtKB=Q06967	14-3-3-like protein GF14-F	IDA	10407019	PubMed	PTHR18860:SF40	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00627	ERK1-2	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IGI	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01451	Galpha	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IC	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	IDA	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00049	Parkinson disease	P01227	20S proteasome	NEUCR|EnsemblGenome=EFNCRG00000006874|UniProtKB=Q8X077	Probable proteasome subunit alpha type-2	TAS	12859888	PubMed	PTHR11599:SF16	PROTEASOME SUBUNIT ALPHA TYPE-2
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	CANLF|Gene=GRIN1|UniProtKB=Q5R1P0	Glutamate receptor ionotropic, NMDA 1	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	STRCO|EnsemblGenome=CAB75393|UniProtKB=P50589	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P02752	Mannose metabolism	P03017	Mannose 6-P isomerase	EMENI|EnsemblGenome=CADANIAG00002007|UniProtKB=P29951	Mannose-6-phosphate isomerase	ISS	8307007	PubMed	PTHR10309:SF0	MANNOSE-6-PHOSPHATE ISOMERASE
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	BOVIN|Ensembl=ENSBTAG00000002349|UniProtKB=P61267	Syntaxin-1B	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P06664	Gonadotropin-releasing hormone receptor pathway	P06729	Pbx1	MOUSE|MGI=MGI=97495|UniProtKB=P41778	Pre-B-cell leukemia transcription factor 1	RCA			PTHR11850:SF89	PRE-B-CELL LEUKEMIA TRANSCRIPTION FACTOR 1
P00034	Integrin signalling pathway	P00922	Collagen	HUMAN|HGNC=2219|UniProtKB=Q14050	Collagen alpha-3(IX) chain	IDA	10778855	PubMed	PTHR44865:SF1	COLLAGEN ALPHA-3 IX  CHAIN
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P02746	Heme biosynthesis	P02970	Coproporphyrinogen oxidase (oxygen independent)	THEMA|EnsemblGenome=TM_1166|UniProtKB=Q9X0P9	Oxygen-independent coproporphyrinogen III oxidase, putative	ISS			PTHR13932:SF5	OXYGEN-INDEPENDENT COPROPORPHYRINOGEN-III OXIDASE-LIKE PROTEIN YGGW
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	YEAST|SGD=S000004235|UniProtKB=Q06549	Cytidine deaminase	ISS			PTHR11644:SF2	CYTIDINE DEAMINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	IDA	10556059	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	MACMU|Ensembl=ENSMMUG00000018272|UniProtKB=F7HEB8	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P05913	Enkephalin release	P05972	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00034	Integrin signalling pathway	P00916	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00029	Huntington disease	P00780	Microtubule	HUMAN|HGNC=16257|UniProtKB=Q9H4B7	Tubulin beta-1 chain	IDA	9454836	PubMed	PTHR11588:SF112	TUBULIN BETA-1 CHAIN
P00036	Interleukin signaling pathway	P00968	Ikk	HUMAN|HGNC=1974|UniProtKB=O15111	Inhibitor of nuclear factor kappa-B kinase subunit alpha	IDA	12235208	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	TAS			PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00047	PDGF signaling pathway	P01174	Rho	MOUSE|MGI=MGI=2152938|UniProtKB=Q812A2	SLIT-ROBO Rho GTPase-activating protein 3	ISS			PTHR14166:SF8	SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 3
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	BOVIN|Ensembl=ENSBTAG00000011761|UniProtKB=F1MDE1	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00025	Hedgehog signaling pathway	P00682	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	IC	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BOVIN|Ensembl=ENSBTAG00000013017|UniProtKB=P04696	Guanine nucleotide-binding protein G(t) subunit alpha-2	ISS	12488551	PubMed	PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=1305941|UniProtKB=F1M324	Phosphoinositide phospholipase C	ISS			PTHR10336:SF84	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04453	ACTH	DANRE|ZFIN=ZDB-GENE-041014-294|UniProtKB=Q5SPP4	Uncharacterized protein	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	SCHPO|PomBase=SPBC13E7.10c|UniProtKB=Q9P6R0	Transcription factor IIIB 60 kDa subunit	ISS			PTHR11618:SF4	TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT
P02721	ATP synthesis	P02798	Cyt C	RAT|RGD=2451|UniProtKB=P62898	Cytochrome c, somatic	ISS	11836241	PubMed	PTHR11961:SF15	CYTOCHROME C
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01182	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00045	Notch signaling pathway	P01113	Pen-2	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P05731	GABA-B receptor II signaling	P05754	Ggamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	RCA	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00057	Wnt signaling pathway	P01457	GBeta	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00017	DNA replication	P00531	Pol alpha	MOUSE|MGI=MGI=99660|UniProtKB=P33609	DNA polymerase alpha catalytic subunit	ISS	20009599	PubMed	PTHR10322:SF21	DNA POLYMERASE ALPHA CATALYTIC SUBUNIT
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	MOUSE|MGI=MGI=1931052|UniProtKB=A6ZI47	Fructose-bisphosphate aldolase	ISS	4812352	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IGI	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00627	ERK1-2	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00052	TGF-beta signaling pathway	P01284	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02734	Chorismate biosynthesis	P02868	Chorismate synthase	AQUAE|EnsemblGenome=aq_081|UniProtKB=O66493	Chorismate synthase	ISS			PTHR21085:SF0	CHORISMATE SYNTHASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000018563|UniProtKB=F6YMF6	Uncharacterized protein	ISS	12562507	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P00048	PI3 kinase pathway	P01189	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00005	Angiogenesis	P00206	Wnt	HUMAN|HGNC=12781|UniProtKB=Q93097	Protein Wnt-2b	IEA	12549854	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	HUMAN|HGNC=6856|UniProtKB=Q9Y6R4	Mitogen-activated protein kinase kinase kinase 4	IGI	11730323	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	DANRE|ZFIN=ZDB-GENE-000502-1|UniProtKB=Q1RLX1	Receptor protein serine/threonine kinase	TAS	10683140	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P00057	Wnt signaling pathway	P01428	Frizzled	HUMAN|HGNC=4040|UniProtKB=Q14332	Frizzled-2	IDA	8717036	PubMed	PTHR11309:SF34	FRIZZLED-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00034	Integrin signalling pathway	P00920	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04397	p53 pathway by glucose deprivation	P04641	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04395	Vasopressin synthesis	P04597	Signal Peptide	RAT|RGD=3238|UniProtKB=P01179	Oxytocin-neurophysin 1	ISS	9756087	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00018	EGF receptor signaling pathway	P00539	14-3-3	EMENI|EnsemblGenome=CADANIAG00005943|UniProtKB=Q5B4M9	1433_TRIHA 14-3-3 PROTEIN HOMOLOG (TH1433)	IGI	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_56698|UniProtKB=C3XYC3	Putative uncharacterized protein	IDA	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00013	Cell cycle	P00484	Cyclin D	HUMAN|HGNC=1583|UniProtKB=P30279	G1/S-specific cyclin-D2	ISS	93275661	PubMed	PTHR10177:SF66	G1/S-SPECIFIC CYCLIN-D2
P00030	Hypoxia response via HIF activation	P00824	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00111	C99	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00049	Parkinson disease	P01208	Hsp70	XENTR|Xenbase=XB-GENE-480060|UniProtKB=F6UZ27	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CAEBR|Gene=CBG12380|UniProtKB=A8XFA7	Protein CBR-HUM-1	ISS			PTHR13140:SF663	HEAVY CHAIN, UNCONVENTIONAL MYOSIN
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MOUSE|MGI=MGI=95816|UniProtKB=B1AS29	Glutamate receptor ionotropic, kainate 3	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00052	TGF-beta signaling pathway	P01289	I-Smads	CANLF|Ensembl=ENSCAFG00000017332|UniProtKB=E2RB30	Mothers against decapentaplegic homolog	ISS	9335505	PubMed	PTHR13703:SF28	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 6
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	ARATH|TAIR=AT1G13890|UniProtKB=Q9LMG8	Putative SNAP25 homologous protein SNAP30	IC			PTHR19305:SF7	SNAP25 HOMOLOGOUS PROTEIN SNAP30-RELATED
P00019	Endothelin signaling pathway	P00590	IP3 R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00021	FGF signaling pathway	P00623	FGF	HUMAN|HGNC=3677|UniProtKB=Q9NP95	Fibroblast growth factor 20	IGI	11306498	PubMed	PTHR11486:SF72	FIBROBLAST GROWTH FACTOR 20
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04633	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00046	Oxidative stress response	P01129	JNK1/2	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	RCA	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00047	PDGF signaling pathway	P01145	c-fos	MOUSE|MGI=MGI=106658|UniProtKB=Q9JM73	Serum response factor	ISS			PTHR11945:SF221	SERUM RESPONSE FACTOR
P00021	FGF signaling pathway	P00628	JNK1-3	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IGI	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04552	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	IDA	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	MOUSE|MGI=MGI=97453|UniProtKB=P35454	Oxytocin-neurophysin 1	ISS	1706187	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00029	Huntington disease	P00805	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00777	CBP	HUMAN|HGNC=3373|UniProtKB=Q09472	Histone acetyltransferase p300	IDA	10664585	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g229095|UniProtKB=A7S027	Predicted protein	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P06214	GBB signaling pathway	P06294	GBB	DROME|FlyBase=FBgn0024234|UniProtKB=P27091	Protein 60A	IDA	9759503	PubMed	PTHR11848:SF54	PROTEIN 60A-RELATED
P06959	CCKR signaling map	G07287	TFF1	HUMAN|HGNC=11755|UniProtKB=P04155	Trefoil factor 1	RCA	12891554	PubMed	PTHR13826:SF18	TREFOIL FACTOR 1
P00048	PI3 kinase pathway	P01185	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	IC	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00005	Angiogenesis	P00233	CSL	MOUSE|MGI=MGI=96522|UniProtKB=P31266	Recombining binding protein suppressor of hairless	ISS	12145413	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00017	DNA replication	P00527	Histones	BRAFL|Gene=BRAFLDRAFT_108838|UniProtKB=C3ZYM6	Histone H3	ISS	12413958	PubMed	PTHR11426:SF168	HISTONE H3.2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BOVIN|Ensembl=ENSBTAG00000006189|UniProtKB=P63258	Actin, cytoplasmic 2	ISS	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00036	Interleukin signaling pathway	P00981	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	DROME|FlyBase=FBgn0263111|UniProtKB=P91645	Voltage-dependent calcium channel type A subunit alpha-1	ISS	8386525	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12676940	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	ECOLI|EcoGene=EG10660|UniProtKB=P00452	Ribonucleoside-diphosphate reductase 1 subunit alpha	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	PANTR|Ensembl=ENSPTRG00000011049|UniProtKB=H2QGF9	Glycogen synthase kinase 3 alpha	ISS	21361340	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	MONDO|Ensembl=ENSMODG00000024440|UniProtKB=F7DJJ2	Muscarinic acetylcholine receptor	ISS	8100450	PubMed	PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00052	TGF-beta signaling pathway	P01275	P38	CAEEL|WormBase=WBGene00004055|UniProtKB=Q17446	Mitogen-activated protein kinase pmk-1	TAS	11274345	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00004	Alzheimer disease-presenilin pathway	P00113	Erb-B4 transmembrane fragment	ORNAN|Ensembl=ENSOANG00000007021|UniProtKB=F7GAV2	Receptor protein-tyrosine kinase	ISS	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00021	FGF signaling pathway	P00633	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12805548	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00223	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS			PTHR24356:SF310	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01192	p110	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MACMU|Ensembl=ENSMMUG00000014807|UniProtKB=F6W548	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00628	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01472	Histone deacetylase	ASHGO|EnsemblGenome=AGOS_AGR395W|UniProtKB=Q74Z12	Histone deacetylase	ISS	10485845	PubMed	PTHR10625:SF141	HISTONE DEACETYLASE RPD3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	SCHPO|PomBase=SPBC14C8.06|UniProtKB=P78774	Actin-related protein 2/3 complex subunit 1	ISS	12963527	gi	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	BOVIN|Gene=FURIN|UniProtKB=Q28193	Furin	IDA	95328031	PubMed	PTHR42884:SF1	FURIN
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00269	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02721	ATP synthesis	P02798	Cyt C	CANLF|Ensembl=ENSCAFG00000002856|UniProtKB=P00011	Cytochrome c	ISS	5846985	PubMed	PTHR11961:SF15	CYTOCHROME C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	BOVIN|Ensembl=ENSBTAG00000037794|UniProtKB=E1BP87	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF681	MYOSIN-4
P00011	Blood coagulation	P00443	Fibrin polymer cross-linked	PANTR|Ensembl=ENSPTRG00000016534|UniProtKB=H2QQB4	Uncharacterized protein	ISS	223002	gi	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00056	VEGF signaling pathway	P01423	p38MAPK	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00015	Circadian clock system	P00502	Casein kinase I	MACMU|Ensembl=ENSMMUG00000010122|UniProtKB=F7HF84	Casein kinase I isoform epsilon	ISS	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P02788	Xanthine and guanine salvage pathway	P03245	Guanine phosphoribosyl transferase	HUMAN|HGNC=23333|UniProtKB=Q9NRG1	Phosphoribosyltransferase domain-containing protein 1	ISS			PTHR43340:SF5	PHOSPHORIBOSYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1
P00057	Wnt signaling pathway	P01443	Phospholipase C	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00034	Integrin signalling pathway	P00944	Actin	XENTR|Xenbase=XB-GENE-491618|UniProtKB=Q6P378	Actin, cytoplasmic 2	ISS	3487386	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	MONDO|Ensembl=ENSMODG00000008391|UniProtKB=F7A4H4	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00012	Cadherin signaling pathway	P00464	Fyn	DANRE|ZFIN=ZDB-GENE-050706-89|UniProtKB=F1RDG9	Tyrosine-protein kinase fynb	ISS	11078745	PubMed	PTHR24418:SF242	TYROSINE-PROTEIN KINASE FYNB
P00021	FGF signaling pathway	P00632	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IGI	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	PANTR|Ensembl=ENSPTRG00000007537|UniProtKB=H2R1H5	Uncharacterized protein	ISS	12549854	PubMed	PTHR10845:SF11	AXIN-1
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	10799299	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00047	PDGF signaling pathway	P01161	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=1309999|UniProtKB=Q922R0	cAMP-dependent protein kinase catalytic subunit PRKX	RCA	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05953	EPB41L1	RAT|RGD=71087|UniProtKB=Q9WTP0	Band 4.1-like protein 1	ISS	12181426	PubMed	PTHR23280:SF24	BAND 4.1-LIKE PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00029	Huntington disease	P00785	Cytochrome c	CHLRE|EnsemblGenome=CHLREDRAFT_133395|UniProtKB=A8JIU5	Ubiquinol:cytochrome c oxidoreductase cytochrome c1	IDA	9027315	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00833	RGS	MOUSE|MGI=MGI=1354694|UniProtKB=Q9JL25	Regulator of G-protein signaling 1	IDA	10779778	PubMed	PTHR10845:SF34	REGULATOR OF G-PROTEIN SIGNALING 1
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DROME|FlyBase=FBgn0259680|UniProtKB=P83099	Putative protein kinase C delta type homolog	IC	15572354	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00025	Hedgehog signaling pathway	P00682	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00025	Hedgehog signaling pathway	P00682	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	MOUSE|MGI=MGI=2661081|UniProtKB=Q8K348	Activin receptor type-1C	ISS	9395284	PubMed	PTHR23255:SF58	ACTIVIN RECEPTOR TYPE-1C
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	MOUSE|MGI=MGI=99474|UniProtKB=Q91YI4	Beta-arrestin-2	IDA	11742073	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00017	DNA replication	P00533	Pol delta	MOUSE|MGI=MGI=1097163|UniProtKB=O35654	DNA polymerase delta subunit 2	ISS	12522211	PubMed	PTHR10416:SF0	DNA POLYMERASE DELTA SUBUNIT 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00036	Interleukin signaling pathway	P00965	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	XENTR|Xenbase=XB-GENE-491031|UniProtKB=Q6DDA6	Polymerase (RNA) II (DNA directed) polypeptide F	ISS	415387	gi	PTHR10773:SF12	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2
P00020	FAS signaling pathway	P00614	ASK1	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	TAS			PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00796	Kainate receptor	MOUSE|MGI=MGI=95814|UniProtKB=Q60934	Glutamate receptor ionotropic, kainate 1	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-486685|UniProtKB=F6VT32	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00049	Parkinson disease	P01211	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	98269030	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01188	Gbetagamma	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00012	Cadherin signaling pathway	P00465	TCF/LEF	MOUSE|MGI=MGI=96770|UniProtKB=P27782	Lymphoid enhancer-binding factor 1	ISS	11266476	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00029	Huntington disease	P00807	Actin	TRIAD|EnsemblGenome=TriadG63375|UniProtKB=B3S5E4	Non-muscle actin 6.2	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00057	Wnt signaling pathway	P01438	PP2A	BOVIN|Ensembl=ENSBTAG00000005533|UniProtKB=F1N1S8	Uncharacterized protein	ISS	96161994	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00053	T cell activation	P01333	cdc42	TAKRU|Ensembl=ENSTRUG00000008289|UniProtKB=H2T7U8	Uncharacterized protein	ISS	12928366	PubMed	PTHR24072:SF129	CDC42L PROTEIN
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00541	Spry	RAT|RGD=1311472|UniProtKB=Q5HZA2	Protein Spry2	ISS	12402043	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	SCHMA|EnsemblGenome=Smp_183710|UniProtKB=G4VLW1	Putative actin	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00021	FGF signaling pathway	P00637	MKK4,7	MONDO|Ensembl=ENSMODG00000008266|UniProtKB=F6Z879	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CANLF|Ensembl=ENSCAFG00000012181|UniProtKB=F2Z4N7	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00012	Cadherin signaling pathway	P00465	TCF/LEF	PANTR|Ensembl=ENSPTRG00000012128|UniProtKB=H2QI87	Uncharacterized protein	ISS	11266476	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	HUMAN|HGNC=8744|UniProtKB=P16519	Neuroendocrine convertase 2	IDA			PTHR42884:SF13	NEUROENDOCRINE CONVERTASE 2
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8680|UniProtKB=Q9Y5F3	Protocadherin beta-1	IDA	8120095	PubMed	PTHR24028:SF12	PROTOCADHERIN BETA-1
P05730	Endogenous cannabinoid signaling	P05743	CB1	MONDO|Ensembl=ENSMODG00000018290|UniProtKB=F6T8W7	Uncharacterized protein	ISS	114610	OMIM	PTHR22750:SF47	CANNABINOID RECEPTOR 1
P04392	P53 pathway feedback loops 1	P04536	Mdm2	MOUSE|MGI=MGI=96952|UniProtKB=P23804	E3 ubiquitin-protein ligase Mdm2	IGI	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	TAS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00006	Apoptosis signaling pathway	P00306	TRAF2	MOUSE|MGI=MGI=101835|UniProtKB=P39429	TNF receptor-associated factor 2	ISS			PTHR10131:SF21	TNF RECEPTOR-ASSOCIATED FACTOR 2
P00059	p53 pathway	G01571	FAS	RAT|RGD=619831|UniProtKB=Q63199	Tumor necrosis factor receptor superfamily member 6	IGI	10327065	PubMed	PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P04393	Ras Pathway	P04557	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00045	Notch signaling pathway	P01108	Nicastrin	RAT|RGD=631418|UniProtKB=Q8CGU6	Nicastrin	TAS	16096062	PubMed	PTHR21092:SF0	NICASTRIN
P02781	Threonine biosynthesis	P03188	Homoserine dehydrogenase	RHOBA|EnsemblGenome=RB8510|UniProtKB=Q7UFK4	Homoserine dehydrogenase	ISS			PTHR43331:SF1	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00591	PLCbeta	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00018	EGF receptor signaling pathway	P00559	MEK1-2	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	BOVIN|Ensembl=ENSBTAG00000018705|UniProtKB=F1MPC9	Uncharacterized protein	ISS	2255909	PubMed	PTHR11920:SF291	ADENYLATE CYCLASE TYPE 3
P00023	General transcription regulation	P00658	TBP-associated factors	ARATH|TAIR=AT1G73960|UniProtKB=Q8LPF0	Transcription initiation factor TFIID subunit 2	ISS			PTHR15137:SF9	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2
P00054	Toll receptor signaling pathway	P01381	Ubc13	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g137658|UniProtKB=A7S6Q0	Predicted protein	ISS			PTHR43902:SF2	UBIQUITIN-CONJUGATING ENZYME E2 N
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	RAT|RGD=1312009|UniProtKB=D4A280	Serine/threonine-protein kinase PAK 7	ISS			PTHR24361:SF183	SERINE/THREONINE-PROTEIN KINASE PAK 7
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	MACMU|Ensembl=ENSMMUG00000014817|UniProtKB=F6VXD8	Uncharacterized protein	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00047	PDGF signaling pathway	P01167	Ets	MOUSE|MGI=MGI=99253|UniProtKB=P41163	ETS translocation variant 2	ISS	15298723	PubMed	PTHR11849:SF206	ETS TRANSLOCATION VARIANT 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	CHICK|Ensembl=ENSGALG00000001569|UniProtKB=Q9PSX7	Rho-related GTP-binding protein RhoC	ISS	14871999	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00047	PDGF signaling pathway	P01163	c-Jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00059	p53 pathway	G01581	BAX	RAT|RGD=2192|UniProtKB=Q63690	Apoptosis regulator BAX	ISS	8358790	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00009	Axon guidance mediated by netrin	P00357	Netrin	DROME|FlyBase=FBgn0015774|UniProtKB=Q24568	Netrin-B	ISS			PTHR10574:SF365	NETRIN-1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00034	Integrin signalling pathway	P00910	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8316835	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02753	Methionine biosynthesis	P03026	O-Succinyl homoserine lyase	YEAST|SGD=S000001154|UniProtKB=P38716	Uncharacterized trans-sulfuration enzyme YHR112C	ISS			PTHR11808:SF35	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01457	GBeta	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	TAS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MACMU|Ensembl=ENSMMUG00000016675|UniProtKB=F6VTB5	Uncharacterized protein	ISS	14698601	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00053	T cell activation	P01300	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00184	Src	CANLF|Ensembl=ENSCAFG00000008755|UniProtKB=E2RSH8	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00047	PDGF signaling pathway	P01142	p90RSK	MOUSE|MGI=MGI=104558|UniProtKB=P18653	Ribosomal protein S6 kinase alpha-1	ISS	15226426	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00019	Endothelin signaling pathway	P00566	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	ISS	12488551	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00005	Angiogenesis	P00221	JNK1	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	SCHMA|EnsemblGenome=Smp_046600|UniProtKB=G4VLW2	Putative actin-1	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05913	Enkephalin release	P05972	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00049	Parkinson disease	P01208	Hsp70	FUSNN|EnsemblGenome=FN0116|UniProtKB=Q8RH05	Chaperone protein DnaK	ISS	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P00003	Alzheimer disease-amyloid secretase pathway	P00108	ADAM10	BOVIN|Ensembl=ENSBTAG00000005481|UniProtKB=Q10741	Disintegrin and metalloproteinase domain-containing protein 10	IDA	10097139	PubMed	PTHR11905:SF4	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 10
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	TAS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04395	Vasopressin synthesis	P04590	Vasopressin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01472	Histone deacetylase	ANOGA|EnsemblGenome=AGAP001143|UniProtKB=Q7PX00	Histone deacetylase	ISS	10485845	PubMed	PTHR10625:SF132	HISTONE DEACETYLASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00053	T cell activation	P01336	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IGI	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00008	Axon guidance mediated by Slit/Robo	P00355	Rho	SCHPO|PomBase=SPAC1F7.04|UniProtKB=Q09914	GTP-binding protein rho1	ISS	11973360	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P04376	5HT4 type receptor mediated signaling pathway	P04431	5HT transporter	CANLF|Ensembl=ENSCAFG00000018990|UniProtKB=F1PXA1	Transporter	ISS	7681602	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P00048	PI3 kinase pathway	P01185	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00018	EGF receptor signaling pathway	P00552	Ras	MONDO|Ensembl=ENSMODG00000025248|UniProtKB=F7F5X1	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	12810719	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00012	Cadherin signaling pathway	P00471	Cadherin	MONDO|Ensembl=ENSMODG00000003756|UniProtKB=F7AAP1	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF96	CADHERIN-12
P00019	Endothelin signaling pathway	P00566	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	ORNAN|Ensembl=ENSOANG00000003489|UniProtKB=F7FSE3	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00029	Huntington disease	P00810	GAPDH	BACSU|EnsemblGenome=BSU33940|UniProtKB=P09124	Glyceraldehyde-3-phosphate dehydrogenase 1	ISS			PTHR43148:SF2	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE C-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	ISS	2372396	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	BOVIN|Ensembl=ENSBTAG00000019963|UniProtKB=P28327	Rhodopsin kinase	IDA	8288567	PubMed	PTHR24355:SF11	RHODOPSIN KINASE
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05918	p38 MAPK pathway	P06025	SRF	RAT|RGD=1559787|UniProtKB=D3ZHH8	Protein Srf	ISS	15647354	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00054	Toll receptor signaling pathway	P01355	AP1	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04393	Ras Pathway	P04555	PDK	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	ORNAN|Ensembl=ENSOANG00000002226|UniProtKB=F6TPX7	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P02742	Tetrahydrofolate biosynthesis	P02944	Phosphoribosylglycinamide formyltransferase	THEMA|EnsemblGenome=TM_1248|UniProtKB=Q9X0X5	Phosphoribosylglycinamide formyltransferase	ISS			PTHR43369:SF2	PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	ORNAN|Ensembl=ENSOANG00000004342|UniProtKB=F6S3B9	Uncharacterized protein	ISS	12181435	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P00010	B cell activation	P00402	Jnk	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02748	Isoleucine biosynthesis	P02998	Dihydroxyacid dehydratase	METAC|EnsemblGenome=MA_3373|UniProtKB=Q8TKM8	Dihydroxy-acid dehydratase 2	ISS			PTHR43661:SF3	DIHYDROXY-ACID DEHYDRATASE
P00056	VEGF signaling pathway	P01409	cPLA2	MACMU|Ensembl=ENSMMUG00000021423|UniProtKB=F7EEZ1	Phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	IGI	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IDA	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MACMU|Ensembl=ENSMMUG00000005238|UniProtKB=F7BWT2	Uncharacterized protein	ISS	12441358	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00037	Ionotropic glutamate receptor pathway	P01026	KA	DANRE|Ensembl=ENSDARG00000070511|UniProtKB=E7F5R2	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF282	GLUTAMATE RECEPTOR-RELATED
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04556	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IDA	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00045	Notch signaling pathway	P01105	TACE	PANTR|Ensembl=ENSPTRG00000011640|UniProtKB=H2R900	Uncharacterized protein	ISS	9774383	PubMed	PTHR11905:SF171	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17
P00029	Huntington disease	P00811	Arp2/3 complex	ORNAN|Ensembl=ENSOANG00000000999|UniProtKB=F6WN02	Actin-related protein 2/3 complex subunit 5	ISS	12473693	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	HUMAN|HGNC=19663|UniProtKB=Q9UBI6	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IDA	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02744	Fructose galactose metabolism	P02966	Hexokinase	HUMAN|HGNC=4922|UniProtKB=P19367	Hexokinase-1	RCA			PTHR19443:SF10	HEXOKINASE-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	XENTR|Xenbase=XB-GENE-984047|UniProtKB=F7E152	Uncharacterized protein (Fragment)	ISS	9388255	PubMed	PTHR10292:SF7	CLATHRIN HEAVY CHAIN 1
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P02751	Lysine biosynthesis	P03010	Diaminopimelate epimerase	ORYSJ|Gene=LOC_Os12g37960|UniProtKB=Q2QNF7	Diaminopimelate epimerase, chloroplastic	RCA			PTHR31689:SF0	DIAMINOPIMELATE EPIMERASE, CHLOROPLASTIC
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00010	B cell activation	P00375	Calmodulin	MONDO|Ensembl=ENSMODG00000002696|UniProtKB=F7CY56	Uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF335	CALMODULIN, STRIATED MUSCLE
P00059	p53 pathway	P01486	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	10693759	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01455	Smad4	SCHMA|EnsemblGenome=Smp_013060|UniProtKB=Q9GQN9	Mothers against decapentaplegic homolog	IDA			PTHR13703:SF40	PROTEIN MOTHERS AGAINST DPP
P05915	Opioid proenkephalin pathway	P05994	G-protein	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00020	FAS signaling pathway	P00604	Pro-Caspase8	MOUSE|MGI=MGI=1261423|UniProtKB=O89110	Caspase-8	IGI	8681376	PubMed	PTHR10454:SF162	CASPASE-8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000008269|UniProtKB=H2QBE4	Cadherin 3, type 1, P-cadherin (Placental)	ISS	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00047	PDGF signaling pathway	P01164	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00049	Parkinson disease	P01238	14-3-3	HUMAN|HGNC=12849|UniProtKB=P31946	14-3-3 protein beta/alpha	IDA	10407019	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000002647|UniProtKB=F7DIB7	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00034	Integrin signalling pathway	P00936	PI3K	ANOGA|EnsemblGenome=AGAP011036|UniProtKB=A0NBA9	AGAP011036-PA (Fragment)	IPI	7937853	PubMed	PTHR10048:SF64	LD28067P
P00029	Huntington disease	P00796	Kainate receptor	MONDO|Ensembl=ENSMODG00000018065|UniProtKB=F7G485	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	ARATH|TAIR=AT4G24480|UniProtKB=F4JQX7	Protein kinase family protein	ISS			PTHR44329:SF2	PROTEIN KINASE FAMILY PROTEIN
P00023	General transcription regulation	P00658	TBP-associated factors	MOUSE|MGI=MGI=1346348|UniProtKB=Q9R1C0	Transcription initiation factor TFIID subunit 7	ISS			PTHR12228:SF6	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 7
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000000365|UniProtKB=F6R9F4	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00078	Alpha1A/1B/1C	MOUSE|MGI=MGI=87935|UniProtKB=P30545	Alpha-2B adrenergic receptor	IC	11781138	PubMed	PTHR24248:SF26	ALPHA-2B ADRENERGIC RECEPTOR
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	HUMAN|HGNC=18855|UniProtKB=Q68CJ9	Cyclic AMP-responsive element-binding protein 3-like protein 3	RCA			PTHR22952:SF98	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 3
P00029	Huntington disease	P00775	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	8649368	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DANRE|ZFIN=ZDB-GENE-030131-6503|UniProtKB=Q7ZUC5	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF297	PROTEIN KINASE C DELTA TYPE
P00046	Oxidative stress response	P01124	Myc	CHICK|Ensembl=ENSGALG00000016308|UniProtKB=P01109	Myc proto-oncogene protein	TAS	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	TAS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00005	Angiogenesis	P00246	Ang-2	PANTR|Ensembl=ENSPTRG00000019947|UniProtKB=H2QVQ1	Uncharacterized protein	ISS	9204896	PubMed	PTHR19143:SF199	ANGIOPOIETIN-2
P00047	PDGF signaling pathway	P01150	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	PANTR|Ensembl=ENSPTRG00000021698|UniProtKB=H2R3J0	CTP synthase	ISS			PTHR11550:SF2	CTP SYNTHASE 2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	94280860	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00048	PI3 kinase pathway	P01202	p85	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00021	FGF signaling pathway	P00625	MKK3,6	MOUSE|MGI=MGI=1346870|UniProtKB=P70236	Dual specificity mitogen-activated protein kinase kinase 6	RCA			PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P02747	Histidine biosynthesis	P02993	Phosphoribosylformimino-5-amino-1-phosphoribosyl-4 imadazol carboxamide isomerase	DEIRA|EnsemblGenome=DR_2495|UniProtKB=Q9RRJ5	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase	ISS			PTHR43090:SF2	1- 5-PHOSPHORIBOSYL -5-  5-PHOSPHORIBOSYLAMINO METHYLIDENEAMINO  IMIDAZOLE-4-CARBOXAMIDE ISOMERASE
P00036	Interleukin signaling pathway	P00972	MNK1/2	RAT|RGD=1305728|UniProtKB=Q5U2N4	MAP kinase-interacting serine/threonine-protein kinase 2	ISS	11463832	PubMed	PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	RAT|RGD=1303144|UniProtKB=Q68FP8	Adenylate kinase 8	ISS			PTHR23359:SF102	ADENYLATE KINASE 8
P00053	T cell activation	P01332	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00644	p38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IGI	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00057	Wnt signaling pathway	P01428	Frizzled	CHICK|Gene=FZD7|UniProtKB=O57329	Frizzled-7	IDA	11212302	PubMed	PTHR11309:SF31	FRIZZLED-7
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	MOUSE|MGI=MGI=894315|UniProtKB=Q99JI6	Ras-related protein Rap-1b	ISS	8576107	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P06959	CCKR signaling map	G06969	HDC	HUMAN|HGNC=4855|UniProtKB=P19113	Histidine decarboxylase	RCA	8662934	PubMed	PTHR11999:SF68	HISTIDINE DECARBOXYLASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00051	TCA cycle	P01268	Aconitase	HUMAN|HGNC=118|UniProtKB=Q99798	Aconitate hydratase, mitochondrial	RCA			PTHR43160:SF3	ACONITATE HYDRATASE, MITOCHONDRIAL
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	DANRE|ZFIN=ZDB-GENE-990415-166|UniProtKB=P79737	GTPase NRas	ISS	9116869	PubMed	PTHR24070:SF189	GTPASE NRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	TAS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00029	Huntington disease	P00812	Caspase 3	HUMAN|HGNC=1504|UniProtKB=P42574	Caspase-3	IDA	7983002	PubMed	PTHR10454:SF198	CASPASE-3
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00034	Integrin signalling pathway	P00922	Collagen	MACMU|Ensembl=ENSMMUG00000011444|UniProtKB=F7B3Z7	Uncharacterized protein	ISS	10778855	PubMed	PTHR24023:SF58	COLLAGEN ALPHA-1 II  CHAIN
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DANRE|ZFIN=ZDB-GENE-040718-134|UniProtKB=Q6DH55	Guanine nucleotide binding protein (G protein), beta polypeptide 3, like	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00018	EGF receptor signaling pathway	P00539	14-3-3	HUMAN|HGNC=10773|UniProtKB=P31947	14-3-3 protein sigma	ISS	10407019	PubMed	PTHR18860:SF14	14-3-3 PROTEIN SIGMA
P00056	VEGF signaling pathway	P01409	cPLA2	CANLF|Ensembl=ENSCAFG00000013778|UniProtKB=F6UQ33	Phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00019	Endothelin signaling pathway	P00586	Gq	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00050	Plasminogen activating cascade	P01260	pro-MMP-3	PANTR|Ensembl=ENSPTRG00000004220|UniProtKB=H2Q4N2	Matrix metallopeptidase 3 (Stromelysin 1, progelatinase)	ISS	3477804	PubMed	PTHR10201:SF215	STROMELYSIN-1
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	MOUSE|MGI=MGI=88275|UniProtKB=Q61301	Catenin alpha-2	TAS	1638632	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P00056	VEGF signaling pathway	P01411	Ras	DICPU|Gene=DICPUDRAFT_51488|UniProtKB=F1A411	Putative uncharacterized protein rasC	ISS	94119591	PubMed	PTHR24070:SF251	RAS-LIKE PROTEIN RASC
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01332	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANAL|CGD=CAL0006065|UniProtKB=Q59LC4	Phosphoinositide phospholipase C	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	HUMAN|HGNC=144|UniProtKB=P63261	Actin, cytoplasmic 2	IC	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00057	Wnt signaling pathway	P01428	Frizzled	HUMAN|HGNC=4046|UniProtKB=Q9H461	Frizzled-8	IDA	11212302	PubMed	PTHR11309:SF90	FRIZZLED-8
P00012	Cadherin signaling pathway	P00466	EGFR	CHICK|Ensembl=ENSGALG00000003126|UniProtKB=F1P258	Receptor protein-tyrosine kinase	ISS	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P04397	p53 pathway by glucose deprivation	P04641	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	RAT|RGD=2958|UniProtKB=P63251	G protein-activated inward rectifier potassium channel 1	ISS			PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	ORYSJ|EnsemblGenome=OS01G0591000|UniProtKB=Q9LRE9	Cytosolic aldehyde dehydrogenase	IC			PTHR11699:SF227	SUBFAMILY NOT NAMED
P00049	Parkinson disease	P01213	Cyclin E	MACMU|Ensembl=ENSMMUG00000005358|UniProtKB=F6Q793	Uncharacterized protein	ISS	12628165	PubMed	PTHR10177:SF70	G1/S-SPECIFIC CYCLIN-E2
P00013	Cell cycle	P00481	APC	MOUSE|MGI=MGI=1916249|UniProtKB=Q8K2H6	Anaphase-promoting complex subunit 10	ISS	7657035	gi	PTHR12936:SF0	ANAPHASE-PROMOTING COMPLEX SUBUNIT 10
P00056	VEGF signaling pathway	P01407	Erk	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9836512	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	DANRE|ZFIN=ZDB-GENE-990714-3|UniProtKB=Q9YH61	Glycogen synthase kinase 3 alpha	ISS	11995474	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05918	p38 MAPK pathway	P06031	p38alpha	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00019	Endothelin signaling pathway	P00591	PLCbeta	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00021	FGF signaling pathway	P00629	PP2A	PANTR|Ensembl=ENSPTRG00000017238|UniProtKB=H2QRH7	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01153	GSK3	DICDI|dictyBase=DDB_G0272110|UniProtKB=P51136	Glycogen synthase kinase-3	ISS	21361340	gi	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00047	PDGF signaling pathway	P01143	ERK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS			PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04398	p53 pathway feedback loops 2	P04660	SIAH-1	PANTR|Ensembl=ENSPTRG00000008094|UniProtKB=H2QB23	E3 ubiquitin-protein ligase	ISS	14985507	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P06959	CCKR signaling map	P07095	PKCalpha	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	RCA	15117677	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IDA	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00049	Parkinson disease	P01208	Hsp70	CHICK|Gene=HSPA8|UniProtKB=O73885	Heat shock cognate 71 kDa protein	IDA	12150907	PubMed	PTHR19375:SF239	HEAT SHOCK COGNATE 71 KDA PROTEIN
P00010	B cell activation	P00379	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	ORYSJ|EnsemblGenome=OS01G0267900|UniProtKB=Q0JNS6	Calmodulin-1	ISS	10487978	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00016	Cytoskeletal regulation by Rho GTPase	P00524	LIMK	XENTR|Xenbase=XB-GENE-1011258|UniProtKB=F6RZQ1	Uncharacterized protein (Fragment)	ISS			PTHR44124:SF1	LIM DOMAIN KINASE 1
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	MACMU|Ensembl=ENSMMUG00000005012|UniProtKB=F7AM42	Casein kinase I isoform alpha-like protein	ISS	10617630	PubMed	PTHR11909:SF139	CASEIN KINASE I ISOFORM ALPHA-LIKE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02734	Chorismate biosynthesis	P02870	3-Phosphoshikimate-1-carboxyvinyl transferase	METAC|EnsemblGenome=MA_4544|UniProtKB=Q8THH3	3-phosphoshikimate 1-carboxyvinyltransferase	ISS			PTHR21090:SF5	PENTAFUNCTIONAL AROM POLYPEPTIDE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MOUSE|MGI=MGI=2150393|UniProtKB=Q91ZU9	Glutamate receptor ionotropic, NMDA 3B	ISS	14698601	PubMed	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P00012	Cadherin signaling pathway	P00470	F-actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g169611|UniProtKB=A7SEB1	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00059	p53 pathway	P01486	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01177	P110ACT	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05915	Opioid proenkephalin pathway	P05994	G-protein	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	MACMU|Ensembl=ENSMMUG00000012470|UniProtKB=F7G0B2	Uncharacterized protein	ISS	604904	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_188187|UniProtKB=E9GJ31	Guanine nucleotide binding protein, q polypeptide	ISS	8457205	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00029	Huntington disease	P00788	Calpain	RAT|RGD=70965|UniProtKB=O35920	Calpain-9	IDA	11675509	PubMed	PTHR10183:SF385	CALPAIN-9
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00047	PDGF signaling pathway	P01143	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00274	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00220	c-Jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	89107990	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00048	PI3 kinase pathway	P01188	Gbetagamma	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00048	PI3 kinase pathway	P01177	P110ACT	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	ORNAN|Ensembl=ENSOANG00000004061|UniProtKB=F6TYN8	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P00047	PDGF signaling pathway	P01160	IP3 receptor	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02727	Androgen/estrogene/progesterone biosynthesis	P02826	Estradiol 17beta-dehydrogenase	MACMU|Ensembl=ENSMMUG00000007990|UniProtKB=F7HLK5	Testosterone 17-beta-dehydrogenase 3	ISS			PTHR43899:SF7	TESTOSTERONE 17-BETA-DEHYDROGENASE 3
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00012	Cadherin signaling pathway	P00475	Frizzled	MACMU|Ensembl=ENSMMUG00000019399|UniProtKB=F6QFJ6	Frizzled-6	ISS	11212302	PubMed	PTHR11309:SF75	FRIZZLED-6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00045	Notch signaling pathway	P01103	Next	MACMU|Ensembl=ENSMMUG00000017022|UniProtKB=F7HQZ9	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	RCA	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	CHICK|Ensembl=ENSGALG00000008341|UniProtKB=Q91000	Trans Golgi network protease furin	IDA	10956649	PubMed	PTHR42884:SF1	FURIN
P00010	B cell activation	P00391	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	HUMAN|HGNC=20776|UniProtKB=Q9BUF5	Tubulin beta-6 chain	ISS	12932731	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00012	Cadherin signaling pathway	P00474	Wnt	BOVIN|Ensembl=ENSBTAG00000001668|UniProtKB=F1N6L8	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00057	Wnt signaling pathway	P01465	Ggamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BOVIN|Ensembl=ENSBTAG00000021067|UniProtKB=F2Z4F0	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF46	ALPHA-CENTRACTIN
P00019	Endothelin signaling pathway	P00587	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00012	Cadherin signaling pathway	P00474	Wnt	PANTR|Ensembl=ENSPTRG00000000313|UniProtKB=H2PY99	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	MOUSE|MGI=MGI=2442695|UniProtKB=Q8BH52	Cyclic AMP-responsive element-binding protein 3-like protein 2	RCA			PTHR22952:SF96	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	HUMAN|HGNC=8748|UniProtKB=Q16549	Proprotein convertase subtilisin/kexin type 7	IDA			PTHR42884:SF12	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 7
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01093	AChE	CANLF|Ensembl=ENSCAFG00000014054|UniProtKB=E2RP98	Carboxylic ester hydrolase	ISS	86008285	PubMed	PTHR11559:SF356	ACETYLCHOLINESTERASE
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	97102671	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000025240|UniProtKB=F7A7I3	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00017	DNA replication	P00527	Histones	ANOGA|EnsemblGenome=AGAP012196|UniProtKB=Q7PCS9	Histone H3	ISS	12413958	PubMed	PTHR11426:SF20	HISTONE H3-LIKE CENTROMERIC PROTEIN A
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00022	General transcription by RNA polymerase I	P00657	TBP	CHICK|Gene=TBP|UniProtKB=O13270	TATA-box-binding protein	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	MYCTU|EnsemblGenome=Rv3051c|UniProtKB=P9WH75	Ribonucleoside-diphosphate reductase subunit alpha	ISS			PTHR11573:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT ALPHA
P00049	Parkinson disease	P01219	SAPK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00053	T cell activation	P01331	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IDA	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00634	MEKK1-5	CANLF|Ensembl=ENSCAFG00000000760|UniProtKB=E2R9L4	Uncharacterized protein	ISS	9305639	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00021	FGF signaling pathway	P00632	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00402	Jnk	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00562	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	MACMU|Ensembl=ENSMMUG00000004886|UniProtKB=F7AGT9	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	PANTR|Ensembl=ENSPTRG00000001787|UniProtKB=H2Q0T0	Phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00006	Apoptosis signaling pathway	P00307	ELF2alpha	CANLF|Ensembl=ENSCAFG00000016386|UniProtKB=E2RL17	Uncharacterized protein	ISS	10889505	PubMed	PTHR10602:SF0	EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1
P00005	Angiogenesis	P00242	TCF	HUMAN|HGNC=11641|UniProtKB=Q9NQB0	Transcription factor 7-like 2	IDA	9118222	PubMed	PTHR10373:SF32	TRANSCRIPTION FACTOR 7-LIKE 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	RCA	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06768	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	RCA	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01454	betaTrCP	CANLF|Ensembl=ENSCAFG00000009879|UniProtKB=E2RDC4	Uncharacterized protein	ISS	10074433	PubMed	PTHR44038:SF2	F-BOX/WD REPEAT-CONTAINING PROTEIN 1A
P00020	FAS signaling pathway	P00615	JNK	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	TAS	11707292	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	HUMAN|HGNC=145|UniProtKB=P63267	Actin, gamma-enteric smooth muscle	IC	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	BOVIN|Ensembl=ENSBTAG00000018445|UniProtKB=E1BK87	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00019	Endothelin signaling pathway	P00568	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00034	Integrin signalling pathway	P00925	MEK	BOVIN|Ensembl=ENSBTAG00000012103|UniProtKB=A5PJP8	MAP2K4 protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04384	Gamma-aminobutyric acid synthesis	P04482	Glutamate decarboxylase	RAT|RGD=2653|UniProtKB=Q05683	Glutamate decarboxylase 2	ISS	2247446	PubMed	PTHR11999:SF77	GLUTAMATE DECARBOXYLASE 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02783	Tryptophan biosynthesis	P03209	Anthranilate phosphoribosyl transferase	AQUAE|EnsemblGenome=aq_196|UniProtKB=O66576	Anthranilate phosphoribosyltransferase	ISS			PTHR43285:SF2	ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	BOVIN|Ensembl=ENSBTAG00000018035|UniProtKB=O46680	TGF-beta receptor type-1	TAS	10683140	PubMed	PTHR23255:SF61	TGF-BETA RECEPTOR TYPE-1
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000003399|UniProtKB=H2Q383	Phosphoinositide-3-kinase, class 2, alpha polypeptide	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00053	T cell activation	P01307	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	ANOGA|EnsemblGenome=AGAP012397|UniProtKB=Q7Q0D5	AGAP012397-PA	ISS	606023	OMIM	PTHR10917:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3
P00009	Axon guidance mediated by netrin	P00363	PI3K	ORNAN|Ensembl=ENSOANG00000005917|UniProtKB=F6QM53	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	ISS	8557110	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00021	FGF signaling pathway	P00644	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	ISS	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04397	p53 pathway by glucose deprivation	P04641	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P02738	De novo purine biosynthesis	P02894	IMP cyclohydrolase	MACMU|Ensembl=ENSMMUG00000012318|UniProtKB=F7DFY8	Uncharacterized protein	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P05913	Enkephalin release	P05974	G-Protein (i)	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	IC	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00114	actin	XENTR|Xenbase=XB-GENE-6469705|UniProtKB=Q6P8G3	Actin, alpha sarcomeric/skeletal	ISS	11889139	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00049	Parkinson disease	P01236	Casein kinase II	YEAST|SGD=S000005587|UniProtKB=P19454	Casein kinase II subunit alpha'	IDA	10617630	PubMed	PTHR24054:SF27	CASEIN KINASE II SUBUNIT ALPHA'
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	IDA	4506785	gi	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00053	T cell activation	P01305	Calmodulin	CANLF|Ensembl=ENSCAFG00000030049|UniProtKB=J9NWQ5	Uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF311	CALMODULIN
P04393	Ras Pathway	P04553	PAK	CHICK|Ensembl=ENSGALG00000008058|UniProtKB=F1N8W8	Uncharacterized protein	ISS	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00046	Oxidative stress response	P01135	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	PANTR|Ensembl=ENSPTRG00000006510|UniProtKB=H2Q8K1	Presenilin	ISS	12736250	PubMed	PTHR10202:SF18	PRESENILIN-1
P00053	T cell activation	P01316	MHC-antigen	BOVIN|Ensembl=ENSBTAG00000015228|UniProtKB=Q29630	CD74 molecule, major histocompatibility complex, class II invariant chain	IPI	73139	PubMed	PTHR14093:SF17	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN GAMMA CHAIN
P00021	FGF signaling pathway	P00638	PLCgamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	89107990	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00018	EGF receptor signaling pathway	P00539	14-3-3	CANLF|Ensembl=ENSCAFG00000031015|UniProtKB=J9P6N4	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	CHICK|Ensembl=ENSGALG00000011905|UniProtKB=F1NHT7	Uncharacterized protein	IDA	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BOVIN|Ensembl=ENSBTAG00000014614|UniProtKB=P62739	Actin, aortic smooth muscle	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00018	EGF receptor signaling pathway	P00540	MKK3,6	MONDO|Ensembl=ENSMODG00000001404|UniProtKB=F7BD74	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00627	ERK1-2	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Ensembl=ENSPTRG00000011042|UniProtKB=H2QGF5	Uncharacterized protein	ISS	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00019	Endothelin signaling pathway	P00577	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00990	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MACMU|Ensembl=ENSMMUG00000021514|UniProtKB=F7FFT5	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF757	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-2
P00047	PDGF signaling pathway	P01161	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01242	Casein kinase I	MACMU|Ensembl=ENSMMUG00000010122|UniProtKB=F7HF84	Casein kinase I isoform epsilon	ISS	11865049	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00023	General transcription regulation	P00669	TFIIEalpha	PANTR|Ensembl=ENSPTRG00000015273|UniProtKB=H2QN66	General transcription factor IIE, polypeptide 1, alpha 56kDa	ISS	92065982	PubMed	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01098	CHT1	RAT|RGD=69270|UniProtKB=Q9JMD7	High affinity choline transporter 1	RCA			PTHR11819:SF129	HIGH AFFINITY CHOLINE TRANSPORTER 1
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00056	VEGF signaling pathway	P01425	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00036	Interleukin signaling pathway	P00983	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00012	Cadherin signaling pathway	P00470	F-actin	CHICK|Ensembl=ENSGALG00000028749|UniProtKB=Q5ZMQ2	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	BOVIN|Ensembl=ENSBTAG00000009245|UniProtKB=Q0P594	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00025	Hedgehog signaling pathway	P00682	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00564	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12912997	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	TAKRU|Ensembl=ENSTRUG00000014170|UniProtKB=H2UH21	Uncharacterized protein (Fragment)	IDA	11781138	PubMed	PTHR24248:SF111	ALPHA-2B ADRENERGIC RECEPTOR
P00053	T cell activation	P01333	cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01470	Frodo	PANTR|Ensembl=ENSPTRG00000006397|UniProtKB=H2Q8E0	Dapper, antagonist of beta-catenin, homolog 1	RCA			PTHR15919:SF12	DAPPER HOMOLOG 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	176910	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01181	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	SULSO|EnsemblGenome=SSO0230|UniProtKB=Q980Q7	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00046	Oxidative stress response	P01131	MKP5	HUMAN|HGNC=3069|UniProtKB=P51452	Dual specificity protein phosphatase 3	TAS			PTHR10159:SF485	DUAL SPECIFICITY PROTEIN PHOSPHATASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00015	Circadian clock system	G01501	cry	DANRE|ZFIN=ZDB-GENE-010426-3|UniProtKB=F1R1X1	Uncharacterized protein	ISS			PTHR11455:SF27	CRY1A PROTEIN
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	RCA	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	RAT|RGD=71027|UniProtKB=P42264	Glutamate receptor ionotropic, kainate 3	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00059	p53 pathway	P04609	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00048	PI3 kinase pathway	P01190	PDK1 ACT	CAEEL|WormBase=WBGene00003965|UniProtKB=Q9Y1J3	3-phosphoinositide-dependent protein kinase 1	IGI	10364160	PubMed	PTHR24356:SF309	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00899	IRS 1-4	RAT|RGD=69317|UniProtKB=B1WBQ1	Insulin receptor substrate 3	ISS	5031805	gi	PTHR10614:SF8	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	IDA	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00012	Cadherin signaling pathway	P00471	Cadherin	ORNAN|Ensembl=ENSOANG00000007715|UniProtKB=F6UDX0	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF85	CADHERIN-11
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02785	Valine biosynthesis	P03215	Branched chain amino acid aminotransferase	METAC|EnsemblGenome=MA_4349|UniProtKB=Q8TI08	Branched chain amino acid aminotransferase	ISS			PTHR42743:SF3	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE-LIKE PROTEIN 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00054	Toll receptor signaling pathway	P01352	p38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00009	Axon guidance mediated by netrin	P00356	UNC-5	PANTR|Ensembl=ENSPTRG00000016296|UniProtKB=H2QPW9	Uncharacterized protein	ISS			PTHR12582:SF7	NETRIN RECEPTOR UNC5C
P00029	Huntington disease	P00775	Rac	ORYSJ|EnsemblGenome=OS02G0312600|UniProtKB=Q6Z7L8	Rac-like GTP-binding protein 7	TAS			PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000010195|UniProtKB=E1B7J3	Uncharacterized protein	ISS	11554554	PubMed	PTHR24356:SF175	SERINE/THREONINE-PROTEIN KINASE N3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00020	FAS signaling pathway	P00601	c-Jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	11840290	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	TAS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00322	Cytochrome C	TAKRU|Ensembl=ENSTRUG00000002170|UniProtKB=H2RXW2	Uncharacterized protein	ISS	5106585	PubMed	PTHR11961:SF12	CYTOCHROME C
P04393	Ras Pathway	P04567	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01142	p90RSK	CHICK|Ensembl=ENSGALG00000011473|UniProtKB=F1P1H2	Ribosomal protein S6 kinase	ISS	1922062	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00023	General transcription regulation	P00658	TBP-associated factors	MACMU|Ensembl=ENSMMUG00000012470|UniProtKB=F7G0B2	Uncharacterized protein	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P02757	O-antigen biosynthesis	P03046	dTDP-glucose pyrophosphorylase	GLOVI|Gene=BAC91178|UniProtKB=Q7NGD4	Glucose-1-phosphate thymidylyltransferase	ISS			PTHR42883:SF2	SUBFAMILY NOT NAMED
P06664	Gonadotropin-releasing hormone receptor pathway	P06769	Gbeta	MOUSE|MGI=MGI=101848|UniProtKB=P62881	Guanine nucleotide-binding protein subunit beta-5	RCA	10051575	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00006	Apoptosis signaling pathway	P00260	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12539654	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00001	Adrenaline and noradrenaline biosynthesis	P00071	VAT1	MACMU|Ensembl=ENSMMUG00000014817|UniProtKB=F6VXD8	Uncharacterized protein	ISS			PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	CHICK|Ensembl=ENSGALG00000017238|UniProtKB=F1NWG3	Uncharacterized protein	ISS	7476890	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00012	Cadherin signaling pathway	P00477	GSK3beta	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	7667318	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02772	Pyruvate metabolism	P03135	Phosphoenolpyruvate Carboxykinase	MACMU|Ensembl=ENSMMUG00000022586|UniProtKB=F6ZDT7	Uncharacterized protein	ISS	8325643	PubMed	PTHR11561:SF1	PHOSPHOENOLPYRUVATE CARBOXYKINASE, CYTOSOLIC  GTP
P00034	Integrin signalling pathway	P00948	Rho	CHICK|Ensembl=ENSGALG00000003806|UniProtKB=O93467	GTP-binding protein	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00897	SHIP2	PANTR|Ensembl=ENSPTRG00000004031|UniProtKB=H2Q4C6	Inositol polyphosphate phosphatase-like 1	ISS	10381377	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00010	B cell activation	P00375	Calmodulin	STRPU|EnsemblGenome=SPU_005033|UniProtKB=W4XNQ0	Uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF263	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00034	Integrin signalling pathway	P00936	PI3K	CAEEL|WormBase=WBGene00009552|UniProtKB=G5EDY0	Phosphatidylinositol 3-kinase piki-1	IPI	7937853	PubMed	PTHR10048:SF64	LD28067P
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	CAEEL|WormBase=WBGene00018904|UniProtKB=Q20848	Putative pyrroline-5-carboxylate reductase	ISS			PTHR11645:SF0	PYRROLINE-5-CARBOXYLATE REDUCTASE
P00036	Interleukin signaling pathway	P00975	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	2842690	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00047	PDGF signaling pathway	P01152	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	2574500	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04393	Ras Pathway	P04567	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00066	DOPA decarb.	MOUSE|MGI=MGI=94876|UniProtKB=O88533	Aromatic-L-amino-acid decarboxylase	ISS	90339966	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00006	Apoptosis signaling pathway	P00269	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000005862|UniProtKB=F1PL99	Phosphoinositide phospholipase C	ISS			PTHR10336:SF84	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	CHICK|Ensembl=ENSGALG00000017350|UniProtKB=E1C4Q0	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00128	Erb-B4	PANTR|Ensembl=ENSPTRG00000012883|UniProtKB=H2QJC5	Receptor protein-tyrosine kinase	ISS	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00046	Oxidative stress response	P01135	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	TAS	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04397	p53 pathway by glucose deprivation	P04641	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	DROME|FlyBase=FBgn0030384|UniProtKB=Q9VYN5	AT26486p	ISS	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MONDO|Ensembl=ENSMODG00000018204|UniProtKB=F6PGX6	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P06959	CCKR signaling map	P07127	Adenylate cyclase	HUMAN|HGNC=232|UniProtKB=Q08828	Adenylate cyclase type 1	RCA	7935349	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8972|UniProtKB=O00750	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00007	Axon guidance mediated by semaphorins	P00340	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00011	Blood coagulation	P00443	Fibrin polymer cross-linked	HUMAN|HGNC=3694|UniProtKB=P02679	Fibrinogen gamma chain	ISS	80015086	PubMed	PTHR19143:SF338	FIBRINOGEN GAMMA CHAIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MOUSE|MGI=MGI=1097680|UniProtKB=O09047	C3a anaphylatoxin chemotactic receptor	IDA	12421977	PubMed	PTHR24225:SF28	C3A ANAPHYLATOXIN CHEMOTACTIC RECEPTOR
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	HUMAN|HGNC=1401|UniProtKB=Q02641	Voltage-dependent L-type calcium channel subunit beta-1	IC	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04395	Vasopressin synthesis	P04590	Vasopressin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00005	Angiogenesis	P00238	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	PANTR|Ensembl=ENSPTRG00000013189|UniProtKB=H2QJV1	Uncharacterized protein	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00023	General transcription regulation	P00668	TFIIB	MACMU|Ensembl=ENSMMUG00000003212|UniProtKB=F7EEK0	Transcription factor IIIB 50 kDa subunit	ISS			PTHR11618:SF5	TRANSCRIPTION FACTOR IIIB 50 KDA SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CHICK|Ensembl=ENSGALG00000011809|UniProtKB=F1NMB0	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05915	Opioid proenkephalin pathway	P05994	G-protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DANRE|ZFIN=ZDB-GENE-030131-172|UniProtKB=Q6IQR3	Actin, alpha, cardiac muscle 1a	IC	11889139	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	ORNAN|Ensembl=ENSOANG00000010492|UniProtKB=F7B2E9	Uncharacterized protein	ISS	11055438	PubMed	PTHR10117:SF7	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00004	Alzheimer disease-presenilin pathway	P00153	gammacatenin	MACMU|Ensembl=ENSMMUG00000013048|UniProtKB=F7H7V0	Desmoplakin-3	ISS	9172160	PubMed	PTHR23315:SF12	JUNCTION PLAKOGLOBIN
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000022174|UniProtKB=F6XHZ4	Uncharacterized protein	ISS			PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	BOVIN|Ensembl=ENSBTAG00000011429|UniProtKB=Q8SQ19	Cyclic AMP-responsive element-binding protein 3	ISS	1354612	PubMed	PTHR22952:SF100	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3
P04393	Ras Pathway	P04570	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06819	SMAD2-4	MOUSE|MGI=MGI=108051|UniProtKB=Q62432	Mothers against decapentaplegic homolog 2	RCA	9395284	PubMed	PTHR13703:SF42	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 2
P02748	Isoleucine biosynthesis	P02995	Threonine dehydratase	STRCO|Gene=CAB93730|UniProtKB=Q9K4M2	Putative threonine dehydratase	ISS			PTHR43419:SF8	THREONINE AMMONIA-LYASE
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	IC	11956331	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00557	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	BOVIN|Ensembl=ENSBTAG00000011808|UniProtKB=O18836	Growth/differentiation factor 8	TAS	9759503	PubMed	PTHR11848:SF150	GROWTH/DIFFERENTIATION FACTOR 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00465	TCF/LEF	HUMAN|HGNC=11641|UniProtKB=Q9NQB0	Transcription factor 7-like 2	ISS	9118222	PubMed	PTHR10373:SF32	TRANSCRIPTION FACTOR 7-LIKE 2
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	DROME|FlyBase=FBgn0004242|UniProtKB=P21521	Synaptotagmin 1	IDA	1840599	PubMed	PTHR10024:SF227	SYNAPTOTAGMIN 1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	XENTR|Xenbase=XB-GENE-487309|UniProtKB=Q66KL4	Derriere protein	ISS	9759503	PubMed	PTHR11848:SF151	EMBRYONIC GROWTH/DIFFERENTIATION FACTOR 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IDA	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04398	p53 pathway feedback loops 2	P04651	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00833	RGS	RAT|RGD=620003|UniProtKB=O08773	Regulator of G-protein signaling 14	ISS	8756726	PubMed	PTHR10845:SF179	REGULATOR OF G-PROTEIN SIGNALING 14
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000014828|UniProtKB=F1N1E0	Uncharacterized protein	ISS	14507926	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00015	Circadian clock system	P00505	Cry	DANRE|ZFIN=ZDB-GENE-010426-5|UniProtKB=F1QU08	Uncharacterized protein	ISS			PTHR11455:SF10	SUBFAMILY NOT NAMED
P00010	B cell activation	P00372	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	15210125	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00005	Angiogenesis	P00243	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00035	Interferon-gamma signaling pathway	P00952	Jak2	MACMU|Ensembl=ENSMMUG00000014558|UniProtKB=F7GT47	Tyrosine-protein kinase	ISS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	DANRE|ZFIN=ZDB-GENE-020125-5|UniProtKB=A2CG69	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF356	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	PANTR|Ensembl=ENSPTRG00000011049|UniProtKB=H2QGF9	Glycogen synthase kinase 3 alpha	ISS	12086949	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00029	Huntington disease	P00786	ARF	ORNAN|Ensembl=ENSOANG00000011765|UniProtKB=F6T022	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF119	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 4C
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	PANTR|Ensembl=ENSPTRG00000004963|UniProtKB=H2Q5Y5	Serine/threonine-protein kinase receptor	ISS	9395284	PubMed	PTHR23255:SF66	SERINE/THREONINE-PROTEIN KINASE RECEPTOR R3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	IDA	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05731	GABA-B receptor II signaling	P05754	Ggamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00898	FKHR	DROME|FlyBase=FBgn0038197|UniProtKB=Q95V55	Forkhead box protein O	ISS	14775847	gi	PTHR11829:SF179	FORKHEAD BOX PROTEIN O
P00060	Ubiquitin proteasome pathway	P01491	E2	PANTR|Ensembl=ENSPTRG00000002518|UniProtKB=H2Q1X5	Ubiquitin-conjugating enzyme E2D 1	ISS			PTHR24068:SF36	UBIQUITIN-CONJUGATING ENZYME E2 D1
P00034	Integrin signalling pathway	P00944	Actin	MONDO|Ensembl=ENSMODG00000000365|UniProtKB=F6R9F4	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00006	Apoptosis signaling pathway	P00260	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04397	p53 pathway by glucose deprivation	P04641	Akt	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	22081553	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	CHICK|Ensembl=ENSGALG00000015835|UniProtKB=F1NZT2	Uncharacterized protein	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CAEEL|WormBase=WBGene00006539|UniProtKB=G5EF01	TuBulin, Beta	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00005	Angiogenesis	P00249	PAK	MACMU|Ensembl=ENSMMUG00000012033|UniProtKB=F7GWI2	Serine/threonine-protein kinase PAK 2	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00019	Endothelin signaling pathway	P00587	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	G01531	BDNF	MOUSE|MGI=MGI=88145|UniProtKB=P21237	Brain-derived neurotrophic factor	ISS	12117585	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00036	Interleukin signaling pathway	P00990	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P04633	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	MACMU|Ensembl=ENSMMUG00000004886|UniProtKB=F7AGT9	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CHICK|GeneID=396254|UniProtKB=P09244	Tubulin beta-7 chain	ISS	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00034	Integrin signalling pathway	P00925	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IDA	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00023	General transcription regulation	P00658	TBP-associated factors	PANTR|Ensembl=ENSPTRG00000000437|UniProtKB=H2PYH5	TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa	ISS			PTHR12264:SF21	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12
P00021	FGF signaling pathway	P00632	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04552	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02756	N-acetylglucosamine metabolism	P03041	Glucosamine-6-phosphate deaminase	MOUSE|MGI=MGI=1915230|UniProtKB=Q9CRC9	Glucosamine-6-phosphate isomerase 2	ISS			PTHR11280:SF9	GLUCOSAMINE-6-PHOSPHATE ISOMERASE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	IC	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	BOVIN|Ensembl=ENSBTAG00000004256|UniProtKB=P27117	Ornithine decarboxylase	ISS			PTHR11482:SF42	ORNITHINE DECARBOXYLASE
P00018	EGF receptor signaling pathway	P00540	MKK3,6	CHICK|Ensembl=ENSGALG00000004735|UniProtKB=F1NHE1	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00005	Angiogenesis	P00249	PAK	CANLF|Ensembl=ENSCAFG00000004956|UniProtKB=E2REH3	Uncharacterized protein	ISS	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00020	FAS signaling pathway	P00615	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	XENTR|Xenbase=XB-GENE-1005422|UniProtKB=Q5M8I9	Psmd7 protein	ISS			PTHR10540:SF7	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000016815|UniProtKB=F7C9S6	Uncharacterized protein	ISS	12441358	PubMed	PTHR24229:SF52	SOMATOSTATIN RECEPTOR TYPE 4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00048	PI3 kinase pathway	P01182	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ORYSJ|Gene=Os01g0866100|UniProtKB=P0C540	Actin-7	IC	11889126	PubMed	PTHR11937:SF205	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00801	Fos protein	TAKRU|Ensembl=ENSTRUG00000018314|UniProtKB=H2VCA7	Uncharacterized protein (Fragment)	ISS			PTHR23351:SF22	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00558	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04398	p53 pathway feedback loops 2	P04651	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	P01465	Ggamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	LEIMA|EnsemblGenome=LmjF.18.1080|UniProtKB=Q27687	Protein kinase A catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00021	FGF signaling pathway	P00645	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12676940	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	PANTR|Ensembl=ENSPTRG00000016154|UniProtKB=H2QPN2	C-X-C motif chemokine	ISS	2007144	PubMed	PTHR10179:SF70	INTERLEUKIN-8
P00004	Alzheimer disease-presenilin pathway	P00110	Ire-1 N-terminal fragment	MACMU|Ensembl=ENSMMUG00000015185|UniProtKB=F6WBI3	Uncharacterized protein	ISS	10619423	PubMed	PTHR13954:SF17	SERINE/THREONINE-PROTEIN KINASE/ENDORIBONUCLEASE IRE1
P00056	VEGF signaling pathway	P01417	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00958	PIAS	MOUSE|MGI=MGI=2136940|UniProtKB=Q9JM05	E3 SUMO-protein ligase PIAS4	TAS	8682149	PubMed	PTHR10782:SF9	E3 SUMO-PROTEIN LIGASE PIAS4
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01300	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	METJA|EnsemblGenome=MJ_1265|UniProtKB=Q58661	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00049	Parkinson disease	P01237	Complex I	RAT|RGD=621733|UniProtKB=P19234	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	ISS	3100899	PubMed	PTHR10371:SF3	NADH DEHYDROGENASE  UBIQUINONE  FLAVOPROTEIN 2, MITOCHONDRIAL
P02728	Arginine biosynthesis	P02848	N-acetylglutamate synthase	NEUCR|EnsemblGenome=EFNCRG00000000909|UniProtKB=P54898	Protein arg-6, mitochondrial	ISS			PTHR23342:SF0	N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL
P00048	PI3 kinase pathway	P01192	p110	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	DROME|FlyBase=FBgn0283499|UniProtKB=P09208	Insulin-like receptor	ISS	11943559	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P02775	Salvage pyrimidine ribonucleotides	P03151	Uracil phosphoribosyl  transferase	DEIRA|EnsemblGenome=DR_1563|UniProtKB=Q9RU32	Uracil phosphoribosyltransferase	ISS			PTHR10285:SF46	URACIL PHOSPHORIBOSYLTRANSFERASE, CHLOROPLASTIC
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00012	Cadherin signaling pathway	P00470	F-actin	ORYSJ|EnsemblGenome=OS12G0163700|UniProtKB=Q0IPW3	Os12g0163700 protein	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00059	p53 pathway	P01481	ATM/ATR	HUMAN|HGNC=795|UniProtKB=Q13315	Serine-protein kinase ATM	TAS	10196661	PubMed	PTHR11139:SF72	SERINE-PROTEIN KINASE ATM
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00046	Oxidative stress response	P01126	ATF2	MOUSE|MGI=MGI=109349|UniProtKB=P16951	Cyclic AMP-dependent transcription factor ATF-2	TAS	11390664	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00017	DNA replication	P00527	Histones	ARATH|TAIR=AT1G75600|UniProtKB=Q9LR02	Histone H3-like 3	ISS	12413958	PubMed	PTHR11426:SF128	HISTONE H3-LIKE 3
P02774	Salvage pyrimidine deoxyribonucleotides	P03146	Deoxyuridine kinase	ARATH|TAIR=AT5G23070|UniProtKB=F4KBF5	Thymidine kinase b	ISS			PTHR11441:SF2	THYMIDINE KINASE B
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	7925653	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00010	B cell activation	P00391	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00034	Integrin signalling pathway	P00948	Rho	MOUSE|MGI=MGI=106028|UniProtKB=Q62159	Rho-related GTP-binding protein RhoC	IGI	14871999	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00053	T cell activation	P01312	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01435	SWI/SNF	MOUSE|MGI=MGI=88192|UniProtKB=Q3TKT4	Transcription activator BRG1	IDA	11532957	PubMed	PTHR10799:SF76	TRANSCRIPTION ACTIVATOR BRG1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00054	Toll receptor signaling pathway	P01358	ERK1	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00011	Blood coagulation	P00444	FIX	PANTR|Gene=F9|UniProtKB=Q95ND7	Coagulation factor IX	ISS	182609	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	CANLF|Ensembl=ENSCAFG00000010871|UniProtKB=F1PXA0	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00059	p53 pathway	P04625	Cdk2	CANLF|Ensembl=ENSCAFG00000000082|UniProtKB=E2QW70	Uncharacterized protein	ISS	1846803	PubMed	PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00038	JAK/STAT signaling pathway	P01027	STAT	BOVIN|Gene=STAT5B|UniProtKB=Q9TUM3	Signal transducer and activator of transcription 5B	ISS	96102059	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	9298898	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CAEEL|WormBase=WBGene00001666|UniProtKB=Q9BIG5	Guanine nucleotide-binding protein alpha-4 subunit	ISS	12488551	PubMed	PTHR10218:SF216	GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-4 SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00048	PI3 kinase pathway	P01205	NOS	MOUSE|MGI=MGI=97362|UniProtKB=P70313	Nitric oxide synthase, endothelial	ISS	9837777	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	LEPIN|EnsemblGenome=LA_1929|UniProtKB=Q8CXT1	CAP family transcription factor	IC	88234494	PubMed	PTHR45452:SF1	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	RCA			PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00053	T cell activation	P01332	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01087	CAT	BOVIN|Ensembl=ENSBTAG00000016814|UniProtKB=F1MLQ5	Uncharacterized protein	ISS	92155737	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P00012	Cadherin signaling pathway	P00466	EGFR	MOUSE|MGI=MGI=95411|UniProtKB=Q61526	Receptor tyrosine-protein kinase erbB-3	ISS	17432904	gi	PTHR24416:SF88	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05730	Endogenous cannabinoid signaling	P05748	mGluR	RAT|RGD=2746|UniProtKB=P31424	Metabotropic glutamate receptor 5	ISS	8314195	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00021	FGF signaling pathway	P00624	14-3-3	MOUSE|MGI=MGI=108109|UniProtKB=P61982	14-3-3 protein gamma	ISS	99360936	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00029	Huntington disease	P00811	Arp2/3 complex	CAEEL|WormBase=WBGene00000201|UniProtKB=Q9U1R7	ARp2/3 compleX component	TAS	12932731	PubMed	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00049	Parkinson disease	P01227	20S proteasome	RAT|RGD=1307428|UniProtKB=Q4KM35	Proteasome subunit beta type-10	ISS	12859888	PubMed	PTHR11599:SF41	PROTEASOME SUBUNIT BETA TYPE-10
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00021	FGF signaling pathway	P00627	ERK1-2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01150	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	HUMAN|HGNC=1388|UniProtKB=O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	8386525	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00037	Ionotropic glutamate receptor pathway	P01026	KA	TAKRU|Ensembl=ENSTRUG00000009259|UniProtKB=H2TF39	Uncharacterized protein	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	BOVIN|Gene=SLC18A2|UniProtKB=Q27963	Synaptic vesicular amine transporter	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	9860142	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	CHICK|Gene=CHRNA6|UniProtKB=P49581	Neuronal acetylcholine receptor subunit alpha-6	ISS	85270494	PubMed	PTHR18945:SF82	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-6
P04395	Vasopressin synthesis	P04597	Signal Peptide	BOVIN|Ensembl=ENSBTAG00000008026|UniProtKB=P01175	Oxytocin-neurophysin 1	ISS	6717565	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05916	Opioid prodynorphin pathway	P06002	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	HUMAN|HGNC=7881|UniProtKB=P46531	Neurogenic locus notch homolog protein 1	IDA	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	MACMU|Ensembl=ENSMMUG00000000612|UniProtKB=F7CDE0	Nucleoside diphosphate kinase	ISS			PTHR11349:SF49	NUCLEOSIDE DIPHOSPHATE KINASE, MITOCHONDRIAL
P02774	Salvage pyrimidine deoxyribonucleotides	P03146	Deoxyuridine kinase	MOUSE|MGI=MGI=98763|UniProtKB=P04184	Thymidine kinase, cytosolic	ISS			PTHR11441:SF0	THYMIDINE KINASE, CYTOSOLIC
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	RCA	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05918	p38 MAPK pathway	P06040	MSK1	MACMU|Ensembl=ENSMMUG00000005586|UniProtKB=F7G4I3	Ribosomal protein S6 kinase	ISS	9687510	PubMed	PTHR24351:SF115	RIBOSOMAL PROTEIN S6 KINASE ALPHA-5
P00036	Interleukin signaling pathway	P00976	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00005	Angiogenesis	P00243	Raf	DROME|FlyBase=FBgn0003079|UniProtKB=P11346	Raf homolog serine/threonine-protein kinase phl	ISS			PTHR44000:SF2	RAF HOMOLOG SERINE/THREONINE-PROTEIN KINASE PHL
P00004	Alzheimer disease-presenilin pathway	P00170	Aph-1	MONDO|Ensembl=ENSMODG00000018778|UniProtKB=F7ADK5	Uncharacterized protein	ISS	12110170	PubMed	PTHR12889:SF3	GAMMA-SECRETASE SUBUNIT APH-1A
P00053	T cell activation	P01336	Jnk	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00048	PI3 kinase pathway	P01200	SHIP	CAEEL|WormBase=WBGene00002146|UniProtKB=Q17848	Probable type I inositol 1,4,5-trisphosphate 5-phosphatase	IGI			PTHR12997:SF2	TYPE I INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00007	Axon guidance mediated by semaphorins	P00331	PAK	CHICK|Ensembl=ENSGALG00000000681|UniProtKB=E1C3P6	Uncharacterized protein	ISS	14580336	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00053	T cell activation	P01306	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05916	Opioid prodynorphin pathway	P06002	G-protein	NEUCR|EnsemblGenome=EFNCRG00000000159|UniProtKB=F5HH30	Guanine nucleotide-binding protein beta subunit	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	12846562	PubMed	PTHR10202:SF13	PRESENILIN-2
P06959	CCKR signaling map	P07103	PRKD1	HUMAN|HGNC=9407|UniProtKB=Q15139	Serine/threonine-protein kinase D1	RCA	18845574	PubMed	PTHR22968:SF9	SERINE/THREONINE-PROTEIN KINASE D1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00056	VEGF signaling pathway	P01406	VEGF	CHICK|Gene=VEGFA|UniProtKB=P67964	Vascular endothelial growth factor A	ISS			PTHR12025:SF5	VASCULAR ENDOTHELIAL GROWTH FACTOR A
P00053	T cell activation	P01323	I kappa B	MOUSE|MGI=MGI=104741|UniProtKB=Q9Z1E3	NF-kappa-B inhibitor alpha	ISS	12637573	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04455	beta-endorphin	RAT|RGD=3366|UniProtKB=P01194	Pro-opiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00060	Ubiquitin proteasome pathway	P01491	E2	CAEBR|Gene=CBG06002|UniProtKB=A8X150	Protein CBR-LET-70	ISS			PTHR24068:SF74	FI16911P1-RELATED
P00059	p53 pathway	P01486	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01440	Cadherin	CHICK|Ensembl=ENSGALG00000016908|UniProtKB=E1BQF1	Uncharacterized protein	ISS	8120095	PubMed	PTHR43912:SF5	PROTOCADHERIN-9
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ANOGA|EnsemblGenome=AGAP000651|UniProtKB=P84185	Actin-5C	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	BOVIN|Ensembl=ENSBTAG00000019337|UniProtKB=F1MMW7	Receptor protein serine/threonine kinase	ISS	10683140	PubMed	PTHR23255:SF58	ACTIVIN RECEPTOR TYPE-1C
P00047	PDGF signaling pathway	P01150	PKC	MACMU|Ensembl=ENSMMUG00000020588|UniProtKB=F7C0E0	Uncharacterized protein	ISS	125549	gi	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P04393	Ras Pathway	P04546	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	IDA	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-963560|UniProtKB=Q0VFC4	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00034	Integrin signalling pathway	P00921	PINCH	HUMAN|HGNC=16084|UniProtKB=Q7Z4I7	LIM and senescent cell antigen-like-containing domain protein 2	ISS	10022929	PubMed	PTHR24210:SF10	LIM AND SENESCENT CELL ANTIGEN-LIKE-CONTAINING DOMAIN PROTEIN 2
P00009	Axon guidance mediated by netrin	P00364	cdc42	HUMAN|HGNC=1736|UniProtKB=P60953	Cell division control protein 42 homolog	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000010521|UniProtKB=F7DQK7	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00053	T cell activation	P01300	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000019277|UniProtKB=H2QUQ1	Uncharacterized protein	ISS	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1718748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04375	5HT3 type receptor mediated signaling pathway	P04425	K+ channel	RAT|RGD=61997|UniProtKB=O54912	Potassium channel subfamily K member 3	ISS	11875121	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	RAT|RGD=1311791|UniProtKB=Q4KLF8	Actin-related protein 2/3 complex subunit 5	ISS	9230079	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00005	Angiogenesis	P00219	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IGI	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05918	p38 MAPK pathway	P06022	eEF2K	RAT|RGD=2538|UniProtKB=P70531	Eukaryotic elongation factor 2 kinase	RCA	11500363	PubMed	PTHR14187:SF56	EUKARYOTIC ELONGATION FACTOR 2 KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00045	Notch signaling pathway	G01541	E(spl)-C genes	MOUSE|MGI=MGI=1860511|UniProtKB=Q9DBX7	Hairy/enhancer-of-split related with YRPW motif-like protein	IC	10860664	PubMed	PTHR10985:SF79	HAIRY/ENHANCER-OF-SPLIT RELATED WITH YRPW MOTIF-LIKE PROTEIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_94959|UniProtKB=C3XYC4	Putative uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P04384	Gamma-aminobutyric acid synthesis	P04482	Glutamate decarboxylase	BOVIN|Ensembl=ENSBTAG00000008056|UniProtKB=F1N6X2	Uncharacterized protein	ISS	2247446	PubMed	PTHR11999:SF77	GLUTAMATE DECARBOXYLASE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00047	PDGF signaling pathway	P01159	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00029	Huntington disease	P00799	JNK-2	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02775	Salvage pyrimidine ribonucleotides	P03149	Cytidine kinase	ARATH|TAIR=AT1G73980|UniProtKB=Q9C9B9	At1g73980/F2P9_15	ISS			PTHR10285:SF122	URIDINE-CYTIDINE KINASE C
P00056	VEGF signaling pathway	P01425	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	3045562	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00010	B cell activation	P00381	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IGI	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00973	PKB	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01275	P38	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	TAS	20451058	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DANRE|ZFIN=ZDB-GENE-081124-1|UniProtKB=F1QVX3	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF728	MYOSIN HEAVY CHAIN, SKELETAL MUSCLE, ADULT
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00035	Interferon-gamma signaling pathway	P00952	Jak2	MONDO|Ensembl=ENSMODG00000015373|UniProtKB=F6WH53	Tyrosine-protein kinase	ISS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P06959	CCKR signaling map	G07288	MMP9	HUMAN|HGNC=7176|UniProtKB=P14780	Matrix metalloproteinase-9	RCA		PubMed	PTHR10201:SF30	MATRIX METALLOPROTEINASE-9
P00021	FGF signaling pathway	P00627	ERK1-2	ARATH|TAIR=AT1G07880|UniProtKB=Q9LQQ9	Mitogen-activated protein kinase 13	ISS			PTHR24055:SF185	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00034	Integrin signalling pathway	P00936	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	IPI	12660731	PubMed	PTHR10048:SF14	PI-3 KINASE
P00054	Toll receptor signaling pathway	P01374	IRF3	MACMU|Ensembl=ENSMMUG00000022735|UniProtKB=B6CJX6	Interferon regulatory factor 3	ISS			PTHR11949:SF1	INTERFERON REGULATORY FACTOR 3
P00015	Circadian clock system	G01497	cry	MOUSE|MGI=MGI=1270859|UniProtKB=Q9R194	Cryptochrome-2	IEP	14507900	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	ORYSJ|EnsemblGenome=OS01G0772600|UniProtKB=Q8S1J0	Os01g0772600 protein	IDA	10617630	PubMed	PTHR11909:SF153	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00775	Rac	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS			PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00018	EGF receptor signaling pathway	P00551	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IGI	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P06002	G-protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00030	Hypoxia response via HIF activation	P00819	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04558	p38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IDA	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00029	Huntington disease	P00775	Rac	HUMAN|HGNC=672|UniProtKB=P84095	Rho-related GTP-binding protein RhoG	TAS	4757952	gi	PTHR24072:SF158	RHO-RELATED GTP-BINDING PROTEIN RHOG
P00048	PI3 kinase pathway	G01545	scl-1	CAEEL|WormBase=WBGene00008027|UniProtKB=Q18543	SCP-Like extracellular protein	ISS			PTHR10334:SF171	SCP-LIKE EXTRACELLULAR PROTEIN
P00018	EGF receptor signaling pathway	P00561	STAT	XENTR|Xenbase=XB-GENE-5913743|UniProtKB=F6T2X3	Signal transducer and activator of transcription	ISS	11472851	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P05918	p38 MAPK pathway	P06031	p38alpha	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00006	Apoptosis signaling pathway	P00272	ASK1	PANTR|Ensembl=ENSPTRG00000024326|UniProtKB=H2R231	Uncharacterized protein	ISS	12566458	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00011	Blood coagulation	P00458	GP IIIa	BOVIN|Ensembl=ENSBTAG00000009987|UniProtKB=F1MTN1	Integrin beta	ISS	4206165	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P02783	Tryptophan biosynthesis	P03206	Anthranilate synthase	SULSO|EnsemblGenome=SSO0893|UniProtKB=Q06128	Anthranilate synthase component 1	ISS			PTHR11236:SF9	ANTHRANILATE SYNTHASE COMPONENT 1
P04392	P53 pathway feedback loops 1	G04686	p73	DANRE|ZFIN=ZDB-GENE-030814-2|UniProtKB=B0S576	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00030	Hypoxia response via HIF activation	P00824	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DROME|FlyBase=FBgn0014011|UniProtKB=P48554	Ras-related protein Rac2	ISS	12588856	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	HUMAN|HGNC=4593|UniProtKB=Q13255	Metabotropic glutamate receptor 1	IDA	12351712	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00057	Wnt signaling pathway	P01472	Histone deacetylase	MOUSE|MGI=MGI=3704479|UniProtKB=D3YYI8	Histone deacetylase	IDA	10485845	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	TAKRU|Ensembl=ENSTRUG00000000811|UniProtKB=H2RP90	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P04372	5-Hydroxytryptamine degredation	P04401	Monoamine Oxidase	BOVIN|Ensembl=ENSBTAG00000016206|UniProtKB=P21398	Amine oxidase [flavin-containing] A	ISS	8602220	PubMed	PTHR43563:SF3	AMINE OXIDASE  FLAVIN-CONTAINING  A
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	YEAST|SGD=S000001295|UniProtKB=P07278	cAMP-dependent protein kinase regulatory subunit	IC	2372396	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00010	B cell activation	P00401	jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	3136397	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00004	Alzheimer disease-presenilin pathway	P00115	Nicastrin	CAEEL|WormBase=WBGene00000148|UniProtKB=Q23316	Nicastrin	IDA	10993067	PubMed	PTHR21092:SF0	NICASTRIN
P00019	Endothelin signaling pathway	P00566	ERK	ARATH|TAIR=AT2G18170|UniProtKB=Q39027	Mitogen-activated protein kinase 7	IGI			PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P00047	PDGF signaling pathway	P01143	ERK	RAT|RGD=628675|UniProtKB=Q9Z2A6	Mitogen-activated protein kinase 15	ISS	9891064	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00035	Interferon-gamma signaling pathway	P00959	IFNGR1	HUMAN|HGNC=5440|UniProtKB=P38484	Interferon gamma receptor 2	IC			PTHR20859:SF46	INTERFERON GAMMA RECEPTOR 2
P00019	Endothelin signaling pathway	P00577	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04558	p38	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	IDA	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IDA	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MOUSE|MGI=MGI=1338944|UniProtKB=Q61271	Activin receptor type-1B	TAS	9395284	PubMed	PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P04375	5HT3 type receptor mediated signaling pathway	P04425	K+ channel	BOVIN|Ensembl=ENSBTAG00000018193|UniProtKB=E1BHX8	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00892	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8479536	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000018059|UniProtKB=C7G3M9	Glutamate receptor, metabotropic 4	ISS	12351712	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEEL|WormBase=WBGene00004033|UniProtKB=P90980	Protein kinase C-like 2	ISS	3755548	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00021	FGF signaling pathway	P00641	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02744	Fructose galactose metabolism	P02966	Hexokinase	MACMU|Ensembl=ENSMMUG00000011845|UniProtKB=F7H4Y8	Uncharacterized protein	RCA			PTHR19443:SF4	HEXOKINASE-2
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	ARATH|TAIR=AT3G57610|UniProtKB=Q96529	Adenylosuccinate synthetase, chloroplastic	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	PANTR|Ensembl=ENSPTRG00000015968|UniProtKB=H2R2Q6	Uncharacterized protein	ISS	15187023	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	BACSU|EnsemblGenome=BSU17390|UniProtKB=P50621	Ribonucleoside-diphosphate reductase subunit beta	ISS			PTHR23409:SF32	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT BETA
P00029	Huntington disease	P00778	NMDA receptor	PANTR|Ensembl=ENSPTRG00000023608|UniProtKB=H2QZZ2	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00048	PI3 kinase pathway	P01177	P110ACT	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02785	Valine biosynthesis	P03216	Acetolactate synthase	CAEBR|Gene=CBG03380|UniProtKB=A8WUX0	Protein CBG03380	ISS			PTHR18968:SF155	ACETOLACTATE SYNTHASE-LIKE PROTEIN
P06664	Gonadotropin-releasing hormone receptor pathway	P06710	Junc	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	RCA	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P05918	p38 MAPK pathway	P06023	MEF	PANTR|Ensembl=ENSPTRG00000024214|UniProtKB=H2R001	Uncharacterized protein	ISS	11274345	PubMed	PTHR11945:SF25	MYOCYTE-SPECIFIC ENHANCER FACTOR 2C
P00019	Endothelin signaling pathway	P00586	Gq	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00029	Huntington disease	P00800	PolyQ Htt	MACMU|Ensembl=ENSMMUG00000008392|UniProtKB=F6VQZ3	Uncharacterized protein	ISS	8268927	PubMed	PTHR10170:SF10	HUNTINGTIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	TAS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	HUMAN|HGNC=9195|UniProtKB=P52434	DNA-directed RNA polymerases I, II, and III subunit RPABC3	ISS	606023	OMIM	PTHR10917:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3
P05918	p38 MAPK pathway	P06013	ELK	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	RCA	10487205	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00054	Toll receptor signaling pathway	P01375	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	ISS	97102675	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00005	Angiogenesis	P00255	Notch	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00010	B cell activation	P00375	Calmodulin	CAEEL|WormBase=WBGene00000552|UniProtKB=O16305	Calmodulin	ISS			PTHR23050:SF236	CALMODULIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	RCA	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	PHYIT|EnsemblGenome=PITG_06376|UniProtKB=D0N4Q3	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta, putative	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00570	PKA	SCHPO|PomBase=SPAC8C9.03|UniProtKB=P36600	cAMP-dependent protein kinase regulatory subunit	ISS	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04393	Ras Pathway	P04579	Shc	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	IDA	95096035	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00048	PI3 kinase pathway	P01188	Gbetagamma	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	BOVIN|Gene=ADCY1|UniProtKB=P19754	Adenylate cyclase type 1	IDA	89298382	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P00034	Integrin signalling pathway	P00920	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00045	Notch signaling pathway	G01541	E(spl)-C genes	DANRE|ZFIN=ZDB-GENE-980526-144|UniProtKB=Q6PBX3	Her6 protein	TAS	14973298	PubMed	PTHR10985:SF19	TRANSCRIPTION FACTOR HES-1
P00010	B cell activation	P00384	p38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IC	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00019	Endothelin signaling pathway	P00570	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	DAPPU|EnsemblGenome=DAPPUDRAFT_306746|UniProtKB=E9GYE9	Putative uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00018	EGF receptor signaling pathway	P00549	EGF	PANTR|Ensembl=ENSPTRG00000016166|UniProtKB=H2QPP3	Epiregulin	ISS			PTHR10740:SF11	PROEPIREGULIN
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	MOUSE|MGI=MGI=1278315|UniProtKB=Q91VN0	Low-density lipoprotein receptor-related protein 5	ISS	11029006	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00047	PDGF signaling pathway	P01171	PLCgamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	CHICK|Ensembl=ENSGALG00000017238|UniProtKB=F1NWG3	Uncharacterized protein	ISS	8314195	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00029	Huntington disease	P00801	Fos protein	TAKRU|Ensembl=ENSTRUG00000010579|UniProtKB=H2TPU7	Uncharacterized protein	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	CANLF|Ensembl=ENSCAFG00000004882|UniProtKB=F1PAE3	Uncharacterized protein	ISS	12086949	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05918	p38 MAPK pathway	P06021	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00057	Wnt signaling pathway	P01444	Wnt	PANTR|Ensembl=ENSPTRG00000019617|UniProtKB=Q2QLE7	Protein Wnt-2	ISS	8717036	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	PANTR|Ensembl=ENSPTRG00000003199|UniProtKB=H2Q2X8	Uncharacterized protein	ISS			PTHR18945:SF768	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-10
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	TAKRU|Ensembl=ENSTRUG00000014690|UniProtKB=H2UKR9	Uncharacterized protein	ISS	12181435	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00029	Huntington disease	P00786	ARF	HUMAN|HGNC=658|UniProtKB=P84085	ADP-ribosylation factor 5	IPI	12932731	PubMed	PTHR11711:SF307	ADP-RIBOSYLATION FACTOR 5
P00021	FGF signaling pathway	P00623	FGF	MOUSE|MGI=MGI=95518|UniProtKB=P11403	Fibroblast growth factor 4	ISS			PTHR11486:SF31	FIBROBLAST GROWTH FACTOR 4
P00048	PI3 kinase pathway	P01192	p110	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00011	Blood coagulation	P00413	HMWK	PANTR|Ensembl=ENSPTRG00000015717|UniProtKB=H2QNX2	Uncharacterized protein	ISS	4504893	gi	PTHR13814:SF12	KININOGEN-1
P00041	Metabotropic glutamate receptor group I pathway	P01058	Homer	HUMAN|HGNC=17512|UniProtKB=Q86YM7	Homer protein homolog 1	ISS	12653978	PubMed	PTHR10918:SF3	HOMER PROTEIN HOMOLOG 1
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00252	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	7689150	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00018	EGF receptor signaling pathway	P00539	14-3-3	CHICK|Ensembl=ENSGALG00000004143|UniProtKB=Q5ZLQ6	14-3-3 protein beta/alpha	ISS	12618428	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00049	Parkinson disease	P01219	SAPK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	NAS	12040174	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MONDO|Ensembl=ENSMODG00000018204|UniProtKB=F6PGX6	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	DROME|FlyBase=FBgn0065032|UniProtKB=Q9VX82	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	RAT|RGD=620218|UniProtKB=P15337	Cyclic AMP-responsive element-binding protein 1	RCA			PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	2372396	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00013	Cell cycle	P00480	Proteasome	TRYB2|Gene=Tb10.61.2180|UniProtKB=Q388E9	Proteasome regulatory non-ATPase subunit 8	ISS	21975205	PubMed	PTHR10540:SF7	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7
P06664	Gonadotropin-releasing hormone receptor pathway	P06798	PKCe/theta	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-486685|UniProtKB=F6VT32	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000006582|UniProtKB=E1BFV6	Uncharacterized protein	ISS	12441358	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	DANRE|ZFIN=ZDB-GENE-990415-28|UniProtKB=Q7ZU33	Ck2a2 protein	IDA	10617630	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00054	Toll receptor signaling pathway	P01367	MKK3	MACMU|Ensembl=ENSMMUG00000010904|UniProtKB=F7GLY5	Uncharacterized protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	8170357	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00245	Rac	RAT|RGD=1306068|UniProtKB=D4A6C5	Protein Arhgap1	ISS	14724572	PubMed	PTHR23176:SF28	RHO GTPASE-ACTIVATING PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00030	Hypoxia response via HIF activation	P00819	AKT	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	TAS	7876156	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00060	Ubiquitin proteasome pathway	P01491	E2	ORYSJ|EnsemblGenome=OS05G0182500|UniProtKB=Q0DK90	Os05g0182500 protein	ISS			PTHR43898:SF8	SUBFAMILY NOT NAMED
P00008	Axon guidance mediated by Slit/Robo	P00342	Slit	HUMAN|HGNC=11085|UniProtKB=O75093	Slit homolog 1 protein	ISS	10432110	PubMed	PTHR24373:SF39	SLIT HOMOLOG 1 PROTEIN
P00059	p53 pathway	P04616	PDK1/2	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	TAS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00020	FAS signaling pathway	P00615	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00059	p53 pathway	G04694	p110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-8225|UniProtKB=Q7SZZ5	Uncharacterized protein	ISS			PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00024	Glycolysis	P00672	Phosphofructokinase-1	PANTR|Ensembl=ENSPTRG00000022972|UniProtKB=H2R059	ATP-dependent 6-phosphofructokinase	RCA			PTHR13697:SF14	ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE, LIVER TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	ANOGA|EnsemblGenome=AGAP005913|UniProtKB=Q7Q6D2	AGAP005913-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000002658|UniProtKB=F7CB14	Uncharacterized protein	ISS	2039532	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01428	Frizzled	MONDO|Ensembl=ENSMODG00000008701|UniProtKB=F6PWM3	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF22	FRIZZLED-3
P02738	De novo purine biosynthesis	P02902	ADP reductase	HUMAN|HGNC=10451|UniProtKB=P23921	Ribonucleoside-diphosphate reductase large subunit	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CHICK|Gene=CHRM3|UniProtKB=P49578	Muscarinic acetylcholine receptor M3	IDA	11166329	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00047	PDGF signaling pathway	P01167	Ets	BOVIN|Ensembl=ENSBTAG00000008649|UniProtKB=F1N064	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF30	ETS TRANSLOCATION VARIANT 3
P00034	Integrin signalling pathway	P00951	Jnk	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00019	Endothelin signaling pathway	P00591	PLCbeta	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	ANOGA|EnsemblGenome=AGAP005912|UniProtKB=Q7Q6D3	AGAP005912-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02744	Fructose galactose metabolism	P02964	Hexose 1-P uridyltransferase	MACMU|Ensembl=ENSMMUG00000020789|UniProtKB=F7HA02	Galactose-1-phosphate uridylyltransferase	ISS	8400361	PubMed	PTHR11943:SF1	GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE
P00018	EGF receptor signaling pathway	P00564	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	14564011	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00005	Angiogenesis	P00189	Fzd	HUMAN|HGNC=4041|UniProtKB=Q9NPG1	Frizzled-3	IDA	12549854	PubMed	PTHR11309:SF22	FRIZZLED-3
P00006	Apoptosis signaling pathway	P00305	Caspase 3	CANLF|Ensembl=ENSCAFG00000007750|UniProtKB=Q8MKI5	Caspase-3	ISS	11675509	PubMed	PTHR10454:SF198	CASPASE-3
P00021	FGF signaling pathway	P00644	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IGI	12810719	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P06664	Gonadotropin-releasing hormone receptor pathway	P06849	Sos	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	RCA	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00018	EGF receptor signaling pathway	P00539	14-3-3	ORNAN|Ensembl=ENSOANG00000007305|UniProtKB=F6XW91	Uncharacterized protein	ISS	92362864	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00034	Integrin signalling pathway	P00908	p130CAS	MOUSE|MGI=MGI=108091|UniProtKB=Q61140	Breast cancer anti-estrogen resistance protein 1	IPI	8649368	PubMed	PTHR10654:SF15	BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	XENTR|GeneID=394982|UniProtKB=P20399	Actin, alpha cardiac muscle 2	ISS	11889126	PubMed	PTHR11937:SF263	ACTIN
P00005	Angiogenesis	P00256	PLC-gamma	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00059	p53 pathway	G01579	PTEN	CAEEL|WormBase=WBGene00000913|UniProtKB=G5EE01	DAF-18	ISS	9885576	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00059	p53 pathway	P01486	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00925	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00053	T cell activation	P01306	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IGI	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00029	Huntington disease	P00806	TAFII130	PANTR|Ensembl=ENSPTRG00000013695|UniProtKB=H2REF4	Uncharacterized protein	ISS	10973244	PubMed	PTHR15138:SF18	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4
P04393	Ras Pathway	P04572	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	IDA	97102676	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	DROME|FlyBase=FBgn0019947|UniProtKB=O02194	Presenilin homolog	TAS	12369105	PubMed	PTHR10202:SF13	PRESENILIN-2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05917	Opioid proopiomelanocortin pathway	P06004	Mu or Delta receptor	MOUSE|MGI=MGI=97441|UniProtKB=P42866	Mu-type opioid receptor	ISS	11259487	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01152	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	2842690	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00036	Interleukin signaling pathway	P00975	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	2574500	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00057	Wnt signaling pathway	P01457	GBeta	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P05913	Enkephalin release	P05972	PKA	DANRE|ZFIN=ZDB-GENE-040426-2427|UniProtKB=F1Q6C0	Uncharacterized protein (Fragment)	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00977	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	DAPPU|EnsemblGenome=DAPPUDRAFT_223674|UniProtKB=E9GCV0	Putative uncharacterized protein	ISS	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00559	MEK1-2	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	8132661	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DICDI|dictyBase=DDB_G0283907|UniProtKB=P34099	cAMP-dependent protein kinase catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ORYSJ|EnsemblGenome=OS05G0438800|UniProtKB=Q75HX0	Actin	ISS	11889126	PubMed	PTHR11937:SF248	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Ensembl=ENSBTAG00000001067|UniProtKB=E1BAB4	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Gene=GRIK4|UniProtKB=Q5IS46	Glutamate receptor ionotropic, kainate 4	ISS	12871085	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CIOIN|Ensembl=ENSCING00000006957|UniProtKB=F6SYL0	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF89	TUBULIN BETA-4 CHAIN
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02741	Flavin biosynthesis	P02938	Pyrimidine reductase	YEAST|SGD=S000000357|UniProtKB=P33312	2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase	ISS			PTHR45196:SF1	2,5-DIAMINO-6-RIBOSYLAMINO-4 3H -PYRIMIDINONE 5'-PHOSPHATE REDUCTASE
P00005	Angiogenesis	P00243	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IDA	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00807	Actin	TAKRU|Ensembl=ENSTRUG00000014318|UniProtKB=H2UI49	Uncharacterized protein	IDA	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00036	Interleukin signaling pathway	P00973	PKB	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000012427|UniProtKB=H2QIN7	Mitogen-activated protein kinase kinase kinase 2	ISS			PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	MACMU|Ensembl=ENSMMUG00000019999|UniProtKB=F7FNE2	Uncharacterized protein	ISS	92370677	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	IDA	15737619	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00019	Endothelin signaling pathway	P00566	ERK	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00047	PDGF signaling pathway	P01159	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00018	EGF receptor signaling pathway	P00547	PP2A	HUMAN|HGNC=9299|UniProtKB=P67775	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	NAS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	RAT|RGD=2026|UniProtKB=P68035	Actin, alpha cardiac muscle 1	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	MACMU|Ensembl=ENSMMUG00000030200|UniProtKB=F7HPQ7	Uncharacterized protein	ISS			PTHR13218:SF15	TAF11-LIKE PROTEIN ENSP00000332601-RELATED
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IDA	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00034	Integrin signalling pathway	P00907	ERK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS			PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ARATH|TAIR=AT3G46520|UniProtKB=P53497	Actin-12	ISS	10974003	PubMed	PTHR11937:SF276	ACTIN-12
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P02755	Methylmalonyl pathway	P03034	Methylmalonyl-CoA mutase	HALSA|EnsemblGenome=VNG_0673G|UniProtKB=Q9HRJ2	Methylmalonyl-CoA mutase	ISS			PTHR23408:SF19	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IGI	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00053	T cell activation	P01322	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00557	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00644	p38	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05913	Enkephalin release	P05972	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00018	EGF receptor signaling pathway	P00562	p38	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00056	VEGF signaling pathway	P01414	PLC-gamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00005	Angiogenesis	P00238	Ras	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	ISS	22097630	PubMed	PTHR24070:SF189	GTPASE NRAS
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000018202|UniProtKB=E2RPJ2	Mitogen-activated protein kinase	ISS	15085193	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	EMENI|EnsemblGenome=CADANIAG00002670|UniProtKB=Q5BH99	G-protein beta subunit [Source:UniProtKB/TrEMBLAcc:O74214]	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	MOUSE|MGI=MGI=94924|UniProtKB=P61168	D(2) dopamine receptor	ISS	2039532	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P02756	N-acetylglucosamine metabolism	P03036	N-acetylglucosamine-6-phosphate deacetylase	CANAL|CGD=CAL0079139|UniProtKB=Q59RG2	N-acetylglucosamine-6-phosphate deacetylase	ISS			PTHR11113:SF14	N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04371	5-Hydroxytryptamine biosynthesis	P04399	Tryptophan hydroxylase	PANTR|Ensembl=ENSPTRG00000005229|UniProtKB=H2Q6H4	Uncharacterized protein	ISS	14597720	PubMed	PTHR11473:SF16	TRYPTOPHAN 5-HYDROXYLASE 2
P06587	Nicotine pharmacodynamics pathway	P06590	GNG	XENTR|Xenbase=XB-GENE-961282|UniProtKB=Q6DF43	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00006	Apoptosis signaling pathway	P00325	Bim	HUMAN|HGNC=994|UniProtKB=O43521	Bcl-2-like protein 11	IDA	11859372	PubMed	PTHR12044:SF9	BCL-2-LIKE PROTEIN 11
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	HUMAN|HGNC=4586|UniProtKB=Q13224	Glutamate receptor ionotropic, NMDA 2B	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	PHYIT|EnsemblGenome=PITG_06514|UniProtKB=D0N511	Calmodulin	ISS	9753452	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00021	FGF signaling pathway	P00628	JNK1-3	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00024	Glycolysis	P00671	Phosphoglycerate kinase	PYRAE|EnsemblGenome=PAE1742|UniProtKB=Q8ZWK6	Phosphoglycerate kinase	ISS	21664397	PubMed	PTHR11406:SF0	PHOSPHOGLYCERATE KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	BOVIN|Ensembl=ENSBTAG00000021151|UniProtKB=Q27991	Myosin-10	ISS	89264452	PubMed	PTHR13140:SF328	MYOSIN-10
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	MACMU|Ensembl=ENSMMUG00000000612|UniProtKB=F7CDE0	Nucleoside diphosphate kinase	ISS			PTHR11349:SF49	NUCLEOSIDE DIPHOSPHATE KINASE, MITOCHONDRIAL
P00019	Endothelin signaling pathway	P00586	Gq	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05915	Opioid proenkephalin pathway	P05994	G-protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02744	Fructose galactose metabolism	P02964	Hexose 1-P uridyltransferase	YEAST|SGD=S000000222|UniProtKB=P08431	Galactose-1-phosphate uridylyltransferase	ISS	6715281	PubMed	PTHR11943:SF2	GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IC	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	HUMAN|HGNC=9857|UniProtKB=P61224	Ras-related protein Rap-1b	IDA	8576107	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00005	Angiogenesis	P00204	PLD	HUMAN|HGNC=9067|UniProtKB=Q13393	Phospholipase D1	IDA	10497874	PubMed	PTHR18896:SF57	PHOSPHOLIPASE D1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	IC	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	HUMAN|HGNC=11442|UniProtKB=O15400	Syntaxin-7	IC	10321247	PubMed	PTHR19957:SF90	SYNTAXIN-7
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000000576|UniProtKB=F6ZW11	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF91	CADHERIN-7
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IGI	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CHICK|Ensembl=ENSGALG00000011809|UniProtKB=F1NMB0	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00046	Oxidative stress response	P01132	c-jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	12972619	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00049	Parkinson disease	P01242	Casein kinase I	DANRE|ZFIN=ZDB-GENE-040426-2385|UniProtKB=Q6P3K7	Casein kinase I isoform delta-B	ISS	11437445	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00021	FGF signaling pathway	P00629	PP2A	PHYPA|Gene=PHYPADRAFT_165449|UniProtKB=A9SKN8	Serine/threonine-protein phosphatase	ISS			PTHR11668:SF318	SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-4 CATALYTIC SUBUNIT
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00307	ELF2alpha	ANOGA|EnsemblGenome=AGAP011190|UniProtKB=Q7QHH7	AGAP011190-PA (Fragment)	ISS			PTHR10602:SF0	EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00018	EGF receptor signaling pathway	P00562	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00012	Cadherin signaling pathway	P00468	Src	BOVIN|Ensembl=ENSBTAG00000008938|UniProtKB=E1BIM8	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000002016|UniProtKB=F1P3G1	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MONDO|Ensembl=ENSMODG00000012279|UniProtKB=F6YFY5	Uncharacterized protein	ISS	6264430	PubMed	PTHR10218:SF67	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-1
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00012	Cadherin signaling pathway	P00471	Cadherin	CANLF|Ensembl=ENSCAFG00000010175|UniProtKB=E2RJN9	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF311	CADHERIN-22
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00015	Circadian clock system	G01497	cry	ORNAN|Ensembl=ENSOANG00000005350|UniProtKB=F6X852	Uncharacterized protein	ISS	10217146	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	PLAF7|EnsemblGenome=PFB0245c|UniProtKB=O96150	DNA-directed RNA polymerase II 16 kDa subunit, putative	ISS			PTHR21297:SF0	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB4
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00052	TGF-beta signaling pathway	P01286	TGFbeta	HUMAN|HGNC=6066|UniProtKB=P08476	Inhibin beta A chain	TAS	11451570	PubMed	PTHR11848:SF133	INHIBIN BETA A CHAIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MACMU|Ensembl=ENSMMUG00000016675|UniProtKB=F6VTB5	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00029	Huntington disease	P00796	Kainate receptor	MONDO|Ensembl=ENSMODG00000020977|UniProtKB=F6S5B1	Uncharacterized protein (Fragment)	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00029	Huntington disease	P00807	Actin	HUMAN|HGNC=17780|UniProtKB=Q562R1	Beta-actin-like protein 2	IDA	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	PHYPA|Gene=PHYPADRAFT_145621|UniProtKB=A9THD0	Predicted protein	ISS	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00053	T cell activation	P01306	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00047	PDGF signaling pathway	P01154	Ras	XENTR|Xenbase=XB-GENE-491174|UniProtKB=F7CB58	Uncharacterized protein (Fragment)	ISS			PTHR24073:SF335	RAS-RELATED PROTEIN RAB-11B
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MOUSE|MGI=MGI=95819|UniProtKB=P35438	Glutamate receptor ionotropic, NMDA 1	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P02788	Xanthine and guanine salvage pathway	P03248	Deoxyguanosine phosphorylase	MACMU|Ensembl=ENSMMUG00000019126|UniProtKB=F6T0Z6	Purine nucleoside phosphorylase	ISS			PTHR11904:SF12	PURINE NUCLEOSIDE PHOSPHORYLASE
P05918	p38 MAPK pathway	P06040	MSK1	BOVIN|Ensembl=ENSBTAG00000010906|UniProtKB=E1BN61	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF115	RIBOSOMAL PROTEIN S6 KINASE ALPHA-5
P00018	EGF receptor signaling pathway	P00552	Ras	DANRE|ZFIN=ZDB-GENE-040808-67|UniProtKB=Q6AZA4	K-ras	ISS	10825661	PubMed	PTHR24070:SF186	GTPASE KRAS
P00057	Wnt signaling pathway	P01472	Histone deacetylase	DANRE|ZFIN=ZDB-GENE-020419-32|UniProtKB=F1R653	Histone deacetylase	IDA	12665570	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P00054	Toll receptor signaling pathway	P01368	MKK2	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00034	Integrin signalling pathway	P00944	Actin	TAKRU|Ensembl=ENSTRUG00000005447|UniProtKB=P68142	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF354	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P05731	GABA-B receptor II signaling	P05754	Ggamma	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	RCA	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00011	Blood coagulation	P00418	Fibrin monomer	PANTR|Ensembl=ENSPTRG00000016535|UniProtKB=H2QQB5	Uncharacterized protein	ISS	6575700	PubMed	PTHR19143:SF232	FIBRINOGEN ALPHA CHAIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	12805548	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00046	Oxidative stress response	P01135	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00005	Angiogenesis	P00200	Dsh	PANTR|Ensembl=ENSPTRG00000008665|UniProtKB=H2QC24	Dishevelled, dsh homolog 2	ISS	10409711	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	RAT|RGD=61862|UniProtKB=P19491	Glutamate receptor 2	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P04398	p53 pathway feedback loops 2	P04651	Ras	MONDO|Gene=KRAS|UniProtKB=Q07983	GTPase KRas	ISS	99084794	PubMed	PTHR24070:SF186	GTPASE KRAS
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	TAS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	RAT|RGD=2343|UniProtKB=P08483	Muscarinic acetylcholine receptor M3	TAS	12181435	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010034|UniProtKB=F1PEE8	Uncharacterized protein	ISS	15858232	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00048	PI3 kinase pathway	P01188	Gbetagamma	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MOUSE|MGI=MGI=103189|UniProtKB=Q10738	Matrilysin	TAS	12356903	PubMed	PTHR10201:SF143	MATRILYSIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	YEAST|SGD=S000005393|UniProtKB=P48525	Glutamate--tRNA ligase, mitochondrial	ISS			PTHR43311:SF2	GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	NEUCR|EnsemblGenome=EFNCRG00000003893|UniProtKB=P78711	Actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00006	Apoptosis signaling pathway	P00289	FAS	RAT|RGD=619831|UniProtKB=Q63199	Tumor necrosis factor receptor superfamily member 6	ISS	10327065	PubMed	PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	RAT|RGD=620186|UniProtKB=Q5RKH5	Phosphorylase kinase, beta	ISS	10487978	PubMed	PTHR10749:SF8	PHOSPHORYLASE B KINASE REGULATORY SUBUNIT BETA
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	SCHPO|PomBase=SPAC22G7.06c|UniProtKB=Q09794	Protein ura1	ISS			PTHR11405:SF5	CAD PROTEIN
P00045	Notch signaling pathway	P01101	Su(H)	DROME|FlyBase=FBgn0004837|UniProtKB=P28159	Suppressor of hairless protein	ISS			PTHR10665:SF0	SUPPRESSOR OF HAIRLESS PROTEIN
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00567	PKG	DANRE|ZFIN=ZDB-GENE-080225-40|UniProtKB=F1R125	Uncharacterized protein	ISS	12855709	PubMed	PTHR24353:SF68	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00005	Angiogenesis	P00223	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00766	Htt	RAT|RGD=68337|UniProtKB=P51111	Huntingtin	IDA	7620118	PubMed	PTHR10170:SF10	HUNTINGTIN
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS			PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00628	JNK1-3	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00046	Oxidative stress response	P01131	MKP5	ORYSJ|EnsemblGenome=OS01G0347000|UniProtKB=Q5Z8E0	Os01g0347000 protein	ISS			PTHR10159:SF346	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00211	GSK3beta	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00012	Cadherin signaling pathway	P00471	Cadherin	MONDO|Ensembl=ENSMODG00000000040|UniProtKB=F6S0B5	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF9	PROTOCADHERIN-18
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000017330|UniProtKB=Q5DRE0	Protocadherin beta-1	ISS	8120095	PubMed	PTHR24028:SF12	PROTOCADHERIN BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00018	EGF receptor signaling pathway	P00545	JNK1-3	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	BOVIN|Ensembl=ENSBTAG00000018445|UniProtKB=E1BK87	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P05915	Opioid proenkephalin pathway	P05994	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00018	EGF receptor signaling pathway	P00562	p38	NEUCR|EnsemblGenome=EFNCRG00000007023|UniProtKB=Q96TL5	Mitogen-activated protein kinase hog-1	ISS			PTHR24055:SF247	MITOGEN-ACTIVATED PROTEIN KINASE HOG1
P04397	p53 pathway by glucose deprivation	P04640	p53	DANRE|ZFIN=ZDB-GENE-030814-2|UniProtKB=B0S576	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00056	VEGF signaling pathway	P01411	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00566	ERK	CHLRE|EnsemblGenome=CHLREDRAFT_193901|UniProtKB=Q9FXT7	Mitogen-activated protein kinase	NAS			PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01305	Calmodulin	MOUSE|MGI=MGI=103249|UniProtKB=P62204	Calmodulin	ISS	9753452	PubMed	PTHR23050:SF311	CALMODULIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05923	beta-ARR2	MACMU|Ensembl=ENSMMUG00000017654|UniProtKB=F6UI32	Beta-arrestin-2 isoform 1	ISS	9388255	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00029	Huntington disease	P00786	ARF	DANRE|ZFIN=ZDB-GENE-030131-8007|UniProtKB=Q6P2U5	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00053	T cell activation	P01319	PAK	CANLF|Ensembl=ENSCAFG00000004956|UniProtKB=E2REH3	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00005	Angiogenesis	P00211	GSK3beta	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IDA	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	ANOGA|EnsemblGenome=AGAP005912|UniProtKB=Q7Q6D3	AGAP005912-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00551	Akt	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	IGI	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00005	Angiogenesis	P00219	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00037	Ionotropic glutamate receptor pathway	P01015	Glu4	MACMU|Ensembl=ENSMMUG00000010987|UniProtKB=F7GCX9	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00019	Endothelin signaling pathway	P00572	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IGI	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	CANLF|Ensembl=ENSCAFG00000024151|UniProtKB=E2R795	Tyrosine-protein kinase receptor	ISS	12644000	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00019	Endothelin signaling pathway	P00590	IP3 R	DROME|FlyBase=FBgn0010051|UniProtKB=P29993	Inositol 1,4,5-trisphosphate receptor	ISS	11007872	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00059	p53 pathway	P04633	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01336	Jnk	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00060	Ubiquitin proteasome pathway	P01490	E3	CHICK|Ensembl=ENSGALG00000016747|UniProtKB=F1NER6	Uncharacterized protein	ISS			PTHR11254:SF301	UBIQUITIN-PROTEIN LIGASE E3A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00047	PDGF signaling pathway	P01160	IP3 receptor	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00038	JAK/STAT signaling pathway	P01029	Serine kinase	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS			PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00048	PI3 kinase pathway	P01178	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	4504111	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P02741	Flavin biosynthesis	P02939	Lumazine synthase	BACSU|EnsemblGenome=BSU23250|UniProtKB=P11998	6,7-dimethyl-8-ribityllumazine synthase	ISS			PTHR21058:SF0	6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MOUSE|MGI=MGI=2152453|UniProtKB=Q2NL51	Glycogen synthase kinase-3 alpha	ISS	12086949	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	CAEBR|Gene=CBG18174|UniProtKB=A8XT67	Protein CBR-ARX-3	ISS	12963527	gi	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P00049	Parkinson disease	P01241	TH	TAKRU|Ensembl=ENSTRUG00000009267|UniProtKB=A0JGX6	Tyrosine 3-monooxygenase	TAS	12480184	PubMed	PTHR11473:SF34	TYROSINE HYDROXYLASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	TAS	9298898	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MONDO|Ensembl=ENSMODG00000008900|UniProtKB=F7B4C1	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P05730	Endogenous cannabinoid signaling	P05748	mGluR	RAT|RGD=2742|UniProtKB=P23385	Metabotropic glutamate receptor 1	ISS	14614461	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00049	Parkinson disease	P01236	Casein kinase II	CIOIN|Ensembl=ENSCING00000003902|UniProtKB=Q967X2	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00047	PDGF signaling pathway	P01148	Grb2	PANTR|Ensembl=ENSPTRG00000014404|UniProtKB=H2QLR1	Uncharacterized protein	ISS	10021361	PubMed	PTHR24418:SF299	GRB2-RELATED ADAPTER PROTEIN 2
P00019	Endothelin signaling pathway	P00574	Big ET1-4	MOUSE|MGI=MGI=95283|UniProtKB=P22387	Endothelin-1	ISS	12893655	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00014	Cholesterol biosynthesis	P00499	Farnesyl-diphosphate farnesyltransferase	LEIMA|EnsemblGenome=LmjF.31.2940|UniProtKB=Q4Q5W4	Putative squalene synthase	ISS			PTHR11626:SF2	SQUALENE SYNTHASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00852	PYK2	MONDO|Ensembl=ENSMODG00000015932|UniProtKB=F6Z395	Uncharacterized protein	ISS	10753828	PubMed	PTHR24418:SF94	PROTEIN-TYROSINE KINASE 2-BETA
P00048	PI3 kinase pathway	P01199	Galpha	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00053	T cell activation	P01311	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01314	nck	PANTR|Ensembl=ENSPTRG00000015434|UniProtKB=G2HHN0	Cytoplasmic protein NCK1	ISS	12874226	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	RCA	7925653	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02748	Isoleucine biosynthesis	P02998	Dihydroxyacid dehydratase	BACSU|EnsemblGenome=BSU21870|UniProtKB=P51785	Dihydroxy-acid dehydratase	ISS			PTHR43661:SF3	DIHYDROXY-ACID DEHYDRATASE
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=1305171|UniProtKB=G3V8P1	Protein Pcdhb3	ISS	8120095	PubMed	PTHR24028:SF118	PROTOCADHERIN BETA-3
P00034	Integrin signalling pathway	P00931	Integrin beta	PANTR|Ensembl=ENSPTRG00000018965|UniProtKB=H2QU86	Integrin beta	ISS	3487386	PubMed	PTHR10082:SF9	INTEGRIN BETA-8
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00048	PI3 kinase pathway	P01179	PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00127	APP	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00010	B cell activation	P00384	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00557	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	IGI	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	XENTR|Xenbase=XB-GENE-961282|UniProtKB=Q6DF43	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00029	Huntington disease	P00805	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IDA	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P05913	Enkephalin release	P05977	G-Protein (s)	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04371	5-Hydroxytryptamine biosynthesis	P04399	Tryptophan hydroxylase	DANRE|ZFIN=ZDB-GENE-030805-6|UniProtKB=Q6IWP4	Tph1b protein	ISS	14597720	PubMed	PTHR11473:SF23	TRYPTOPHAN 5-HYDROXYLASE 1
P00019	Endothelin signaling pathway	P00590	IP3 R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_126324|UniProtKB=C3XYC2	Putative uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00014	Cholesterol biosynthesis	P00498	Hydroxymethyl glutaryl CoA synthase	MACMU|Ensembl=ENSMMUG00000001226|UniProtKB=F7HQ90	Hydroxymethylglutaryl-CoA synthase, cytoplasmic	ISS	123332	gi	PTHR43323:SF4	HYDROXYMETHYLGLUTARYL-COA SYNTHASE, CYTOPLASMIC
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	IC	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	MACMU|Ensembl=ENSMMUG00000006987|UniProtKB=F7DQJ5	DNA-directed RNA polymerases I, II, and III subunit RPABC2	ISS	415387	gi	PTHR10773:SF12	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	RAT|RGD=1307015|UniProtKB=D3ZRW5	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	PANTR|Ensembl=ENSPTRG00000016891|UniProtKB=H2R5K3	Uncharacterized protein	ISS	12049732	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00005	Angiogenesis	P00243	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P02741	Flavin biosynthesis	P02933	Pyrimidine deaminase	THEMA|EnsemblGenome=TM_1828|UniProtKB=Q9X2E8	Riboflavin biosynthesis protein RibD	ISS			PTHR44288:SF1	RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBD
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	MOUSE|MGI=MGI=95811|UniProtKB=Q9Z2W8	Glutamate receptor 4	ISS	12941441	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	LEIMA|EnsemblGenome=LmjF.35.3960|UniProtKB=E9AFM1	Protein kinase A catalytic subunit isoform 2	ISS	10553940	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00624	14-3-3	MOUSE|MGI=MGI=1891831|UniProtKB=O70456	14-3-3 protein sigma	ISS	10407019	PubMed	PTHR18860:SF14	14-3-3 PROTEIN SIGMA
P00029	Huntington disease	P00807	Actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347740|UniProtKB=E9FXV8	Cytoplasmatic actin	ISS	11889126	PubMed	PTHR11937:SF277	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00219	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00046	Oxidative stress response	P01131	MKP5	BOVIN|Ensembl=ENSBTAG00000046956|UniProtKB=G3MYQ0	Uncharacterized protein	ISS			PTHR10159:SF385	SERINE/THREONINE/TYROSINE-INTERACTING PROTEIN
P06959	CCKR signaling map	G07290	MMP7	HUMAN|HGNC=7174|UniProtKB=P09237	Matrilysin	RCA	20637111	PubMed	PTHR10201:SF143	MATRILYSIN
P00005	Angiogenesis	P00233	CSL	MOUSE|MGI=MGI=1196616|UniProtKB=O08674	Recombining binding protein suppressor of hairless-like protein	ISS	12681948	PubMed	PTHR10665:SF2	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS-LIKE PROTEIN
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00805	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05752	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	HUMAN|HGNC=712|UniProtKB=P32121	Beta-arrestin-2	IDA	9388255	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00046	Oxidative stress response	P01129	JNK1/2	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CHICK|Ensembl=ENSGALG00000009067|UniProtKB=F1NEF4	Uncharacterized protein	IDA			PTHR43962:SF5	MELATONIN RECEPTOR TYPE 1C
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06786	ERK1/2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	RCA	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00508	Cofilin	MONDO|Ensembl=ENSMODG00000012949|UniProtKB=F7D0R0	Uncharacterized protein (Fragment)	ISS			PTHR11913:SF15	COFILIN-2
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MOUSE|MGI=MGI=109349|UniProtKB=P16951	Cyclic AMP-dependent transcription factor ATF-2	TAS	10664585	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	EMENI|EnsemblGenome=CADANIAG00002670|UniProtKB=Q5BH99	G-protein beta subunit [Source:UniProtKB/TrEMBLAcc:O74214]	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00034	Integrin signalling pathway	P00924	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CANLF|Ensembl=ENSCAFG00000003156|UniProtKB=F1PYS6	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF462	MYOSIN-14
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00036	Interleukin signaling pathway	P00965	ERK	PANTR|Ensembl=ENSPTRG00000008867|UniProtKB=H2QCF3	Mitogen-activated protein kinase	ISS	15085193	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CAEEL|WormBase=WBGene00000366|UniProtKB=P34545	Protein cbp-1	TAS	10769018	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P04393	Ras Pathway	P04556	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	3449797	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00056	VEGF signaling pathway	P01407	Erk	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00560	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	HUMAN|HGNC=4583|UniProtKB=Q16478	Glutamate receptor ionotropic, kainate 5	ISS	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00029	Huntington disease	P00811	Arp2/3 complex	ARATH|TAIR=AT2G31300|UniProtKB=Q9SJW6	Actin-related protein 2/3 complex subunit 1B	TAS	12932731	PubMed	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	DROME|FlyBase=FBgn0265784|UniProtKB=Q9VWW0	Cyclic AMP response element-binding protein B	RCA			PTHR22952:SF248	CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN B
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	CHICK|Ensembl=ENSGALG00000004796|UniProtKB=Q90694	Cell division control protein 42 homolog	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00025	Hedgehog signaling pathway	P00682	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00053	T cell activation	P01335	jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00002	Alpha adrenergic receptor signaling pathway	P00078	Alpha1A/1B/1C	MACMU|Ensembl=ENSMMUG00000023112|UniProtKB=B0S4P2	Alpha-1a adrenoceptor transcript variant 1	ISS	11781138	PubMed	PTHR24248:SF16	ALPHA-1A ADRENERGIC RECEPTOR
P06212	DPP-SCW signaling pathway	P06270	PUT	DROME|Gene=Dmel_CG7904|UniProtKB=A0A0B4KG59	Serine/threonine-protein kinase receptor	IEA	http://flybase.org/reports/FBgn0003169.html	Website	PTHR23255:SF70	SERINE/THREONINE-PROTEIN KINASE RECEPTOR
P00019	Endothelin signaling pathway	P00572	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02771	Pyrimidine Metabolism	P03124	Methylmalonate Semialdehyde Dehydrogenase	HUMAN|HGNC=7179|UniProtKB=Q02252	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	IPI	1527093	PubMed	PTHR43866:SF3	METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE  ACYLATING , MITOCHONDRIAL
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	NEUCR|EnsemblGenome=EFNCRG00000006341|UniProtKB=P87253	Protein kinase C-like	TAS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00018	EGF receptor signaling pathway	P00551	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IGI	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00049	Parkinson disease	P01219	SAPK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	NAS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00005	Angiogenesis	P00226	Delta/Serrate	MOUSE|MGI=MGI=1098270|UniProtKB=Q9QYE5	Protein jagged-2	ISS	12826675	PubMed	PTHR44097:SF1	PROTEIN JAGGED-2
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00034	Integrin signalling pathway	P00925	MEK	RAT|RGD=1306620|UniProtKB=B1H230	Map2k3 protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00011	Blood coagulation	P00445	FXa	BOVIN|Ensembl=ENSBTAG00000016385|UniProtKB=P00743	Coagulation factor X	ISS	119759	gi	PTHR44064:SF3	COAGULATION FACTOR X
P00006	Apoptosis signaling pathway	P00260	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	RAT|RGD=1549703|UniProtKB=P82808	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1	ISS			PTHR10937:SF2	GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE  ISOMERIZING  1
P00049	Parkinson disease	P01225	Synphilin	PANTR|Ensembl=ENSPTRG00000017175|UniProtKB=H2R5G1	Uncharacterized protein	ISS	10319874	PubMed	PTHR22882:SF3	SYNPHILIN-1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00059	p53 pathway	P01480	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	IGI	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01457	GBeta	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00004	Alzheimer disease-presenilin pathway	P00149	Pen-2	DROME|FlyBase=FBgn0053198|UniProtKB=Q86BE9	Gamma-secretase subunit pen-2	IDA	12110170	PubMed	PTHR16318:SF0	GAMMA-SECRETASE SUBUNIT PEN-2
P00005	Angiogenesis	P00203	Erk	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01411	Ras	DAPPU|EnsemblGenome=DAPPUDRAFT_301818|UniProtKB=E9I1I7	Putative uncharacterized protein	ISS	20148920	PubMed	PTHR24070:SF385	GTPASE HRAS
P00053	T cell activation	P01322	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	TAS	4506785	gi	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	RCA	10553940	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00053	T cell activation	P01333	cdc42	HUMAN|HGNC=1736|UniProtKB=P60953	Cell division control protein 42 homolog	IDA	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00990	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01190	PDK1 ACT	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	IGI	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00012	Cadherin signaling pathway	P00475	Frizzled	HUMAN|HGNC=4041|UniProtKB=Q9NPG1	Frizzled-3	IDA	8717036	PubMed	PTHR11309:SF22	FRIZZLED-3
P04395	Vasopressin synthesis	P04589	Signal Peptidase	CAEEL|WormBase=WBGene00012550|UniProtKB=Q9XWW1	Probable signal peptidase complex subunit 2	IC	2092035	PubMed	PTHR13085:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 2
P04393	Ras Pathway	P04558	p38	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	ORNAN|Ensembl=ENSOANG00000002061|UniProtKB=F7ANC6	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00053	T cell activation	P01317	CD3 gamma	CHICK|Ensembl=ENSGALG00000007418|UniProtKB=F1N9E2	Uncharacterized protein	ISS			PTHR10570:SF8	T-CELL SURFACE GLYCOPROTEIN CD3 GAMMA CHAIN
P00018	EGF receptor signaling pathway	P00552	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P00047	PDGF signaling pathway	P01168	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01435	SWI/SNF	CHICK|Ensembl=ENSGALG00000003882|UniProtKB=F1NCC9	Uncharacterized protein	ISS	11532957	PubMed	PTHR13711:SF206	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY E MEMBER 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00029	Huntington disease	P00790	beta-Tubulin	SCHMA|EnsemblGenome=Smp_078040|UniProtKB=C4QIC0	Tubulin beta chain,putative	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00005	Angiogenesis	P00214	HIF-1	RAT|RGD=61928|UniProtKB=O35800	Hypoxia-inducible factor 1-alpha	ISS	14526383	PubMed	PTHR23043:SF7	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA
P02779	Thiamin biosynthesis	P03173	Thiamin phosphate synthase	METAC|EnsemblGenome=MA_2722|UniProtKB=Q8TMD6	Thiamine-phosphate synthase	ISS			PTHR20857:SF15	THIAMINE BIOSYNTHETIC BIFUNCTIONAL ENZYME
P00021	FGF signaling pathway	P00629	PP2A	BOVIN|Ensembl=ENSBTAG00000007061|UniProtKB=Q08DP7	Protein phosphatase 2, regulatory subunit B', beta isoform	ISS	10092233	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00056	VEGF signaling pathway	P01407	Erk	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	HUMAN|HGNC=11514|UniProtKB=O43581	Synaptotagmin-7	RCA			PTHR10024:SF344	SYNAPTOTAGMIN-7
P04393	Ras Pathway	P04542	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00010	B cell activation	P00391	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02742	Tetrahydrofolate biosynthesis	P02945	Dihydropteroate synthase	STRCO|Gene=CAC01342|UniProtKB=Q9FBL7	Dihydropteroate synthase	ISS			PTHR20941:SF8	SUBFAMILY NOT NAMED
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	METAC|EnsemblGenome=MA_1266|UniProtKB=Q8TRB4	DNA-directed RNA polymerase subunit H	ISS	11313498	PubMed	PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P00059	p53 pathway	P04623	CBP	CAEEL|WormBase=WBGene00010545|UniProtKB=G5EBG3	CBP/p300 homolog	ISS	8413673	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00057	Wnt signaling pathway	P01428	Frizzled	CAEEL|WormBase=WBGene00003006|UniProtKB=G5EDV1	Transmembrane receptor LIN-17	ISS	8717036	PubMed	PTHR11309:SF130	TRANSMEMBRANE RECEPTOR LIN-17
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	RAT|RGD=1305848|UniProtKB=P85970	Actin-related protein 2/3 complex subunit 2	ISS	10940259	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00056	VEGF signaling pathway	P01411	Ras	DICDI|dictyBase=DDB_G0281385|UniProtKB=P32253	Ras-like protein rasC	ISS	94119591	PubMed	PTHR24070:SF251	RAS-LIKE PROTEIN RASC
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	RCA	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	MONBE|Gene=37852|UniProtKB=A9V489	Predicted protein	IC	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00049	Parkinson disease	P01211	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04397	p53 pathway by glucose deprivation	P04641	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	RCA	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00020	FAS signaling pathway	P00620	CytochromeC	YEAST|SGD=S000005591|UniProtKB=P07143	Cytochrome c1, heme protein, mitochondrial	IGI	15163634	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00052	TGF-beta signaling pathway	P01285	TAK	BOVIN|Ensembl=ENSBTAG00000002625|UniProtKB=A2VDU3	Mitogen-activated protein kinase kinase kinase 7	RCA			PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	PANTR|Ensembl=ENSPTRG00000010386|UniProtKB=H2QF61	Tyrosine-protein kinase receptor	ISS	249616	gi	PTHR24416:SF402	INSULIN RECEPTOR
P05916	Opioid prodynorphin pathway	P06002	G-protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00049	Parkinson disease	P01215	Syntaxin	CAEEL|WormBase=WBGene00009478|UniProtKB=O62236	SYntaXin	IPI			PTHR19957:SF209	LD23667P
P00034	Integrin signalling pathway	P00922	Collagen	HUMAN|HGNC=2213|UniProtKB=P12111	Collagen alpha-3(VI) chain	IDA	10778855	PubMed	PTHR44105:SF2	COLLAGEN ALPHA-3 VI  CHAIN
P05916	Opioid prodynorphin pathway	P06002	G-protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01162	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04393	Ras Pathway	P04570	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CAEEL|WormBase=WBGene00022534|UniProtKB=Q9TY08	SYntaXin	IC			PTHR19957:SF83	SYNTAXIN-16
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01188	Gbetagamma	MACMU|Ensembl=ENSMMUG00000017374|UniProtKB=F7H6T7	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	PANTR|Ensembl=ENSPTRG00000004718|UniProtKB=H2Q5I0	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	15621031	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04586	ProTRH (Pro Thyrotropin-releasing Hormone)	MOUSE|MGI=MGI=98823|UniProtKB=Q62361	Pro-thyrotropin-releasing hormone	ISS	2126343	PubMed	PTHR17530:SF2	PRO-THYROTROPIN-RELEASING HORMONE
P00048	PI3 kinase pathway	P01200	SHIP	MACMU|Ensembl=ENSMMUG00000010451|UniProtKB=F7CRA7	Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2	ISS	12145149	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	HUMAN|HGNC=16767|UniProtKB=Q8TCU5	Glutamate receptor ionotropic, NMDA 3A	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00011	Blood coagulation	P00410	GP IIb	MACMU|Ensembl=ENSMMUG00000012659|UniProtKB=F7E7I7	Uncharacterized protein	ISS	386753	gi	PTHR23220:SF73	INTEGRIN ALPHA-IIB
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	CHICK|Ensembl=ENSGALG00000004796|UniProtKB=Q90694	Cell division control protein 42 homolog	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00054	Toll receptor signaling pathway	P01360	IKKbeta	HUMAN|HGNC=5960|UniProtKB=O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CANLF|Ensembl=ENSCAFG00000015662|UniProtKB=E2RHY4	Uncharacterized protein	ISS	10051575	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00059	p53 pathway	P01486	Akt	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	TAS	98382502	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00048	PI3 kinase pathway	P01179	PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00980	IRS1/2	MOUSE|MGI=MGI=99454|UniProtKB=P35569	Insulin receptor substrate 1	IDA	11701440	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	CHICK|Ensembl=ENSGALG00000005981|UniProtKB=P34822	Dorsalin-1	TAS	9759503	PubMed	PTHR11848:SF157	GROWTH/DIFFERENTIATION FACTOR 2
P04393	Ras Pathway	P04567	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04651	Ras	CHICK|Ensembl=ENSGALG00000014033|UniProtKB=E1BTS2	Uncharacterized protein	ISS	9869449	PubMed	PTHR24070:SF186	GTPASE KRAS
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	DROME|FlyBase=FBgn0031441|UniProtKB=Q9VQE3	CG9962	ISS	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00053	T cell activation	P01305	Calmodulin	BRAFL|Gene=BRAFLDRAFT_87235|UniProtKB=C3ZEV9	Putative uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF245	AT16150P-RELATED
P04372	5-Hydroxytryptamine degredation	P04401	Monoamine Oxidase	DEIRA|EnsemblGenome=DR_A0274|UniProtKB=Q9RYN6	Flavin monoamine oxidase	ISS			PTHR42923:SF10	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01435	SWI/SNF	SCHPO|PomBase=SPAC23G3.10c|UniProtKB=Q9P7S3	SWI/SNF and RSC complexes subunit ssr3	IDA	11532957	PubMed	PTHR13844:SF7	BRAHMA-ASSOCIATED PROTEIN OF 60 KDA
P00057	Wnt signaling pathway	P01444	Wnt	PANTR|Ensembl=ENSPTRG00000004519|UniProtKB=H2Q569	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04556	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IDA	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MONDO|Ensembl=ENSMODG00000003295|UniProtKB=F7EG01	Serine/threonine-protein kinase receptor	ISS	9395284	PubMed	PTHR23255:SF64	ACTIVIN RECEPTOR TYPE-2A
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00006	Apoptosis signaling pathway	P00302	ATF	BOVIN|Ensembl=ENSBTAG00000002295|UniProtKB=F1N177	Uncharacterized protein	ISS	9819389	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	IDA	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P04393	Ras Pathway	P04548	ATF2	MONDO|Ensembl=ENSMODG00000009514|UniProtKB=F7EVK3	Uncharacterized protein	ISS	11390664	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	RAT|RGD=2321905|UniProtKB=D4ACM8	Protein Fzd7	ISS	8717036	PubMed	PTHR11309:SF31	FRIZZLED-7
P00013	Cell cycle	P00480	Proteasome	MONDO|Ensembl=ENSMODG00000005337|UniProtKB=F7CHT9	Uncharacterized protein	ISS	9727008	PubMed	PTHR10410:SF5	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 14
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	DANRE|ZFIN=ZDB-GENE-020125-3|UniProtKB=E7F1V8	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P05730	Endogenous cannabinoid signaling	P05746	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P06664	Gonadotropin-releasing hormone receptor pathway	P06701	TCF	MOUSE|MGI=MGI=1202876|UniProtKB=Q9Z1J1	Transcription factor 7-like 1	RCA	11266476	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	98189216	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00037	Ionotropic glutamate receptor pathway	P01020	NSF	BOVIN|Ensembl=ENSBTAG00000008442|UniProtKB=F1MZU2	Uncharacterized protein	ISS	7969419	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P04393	Ras Pathway	P04575	TAK	MACMU|Ensembl=ENSMMUG00000003024|UniProtKB=F6VN73	Uncharacterized protein	ISS	10683140	PubMed	PTHR26392:SF77	EXTRACELLULAR TYROSINE-PROTEIN KINASE PKDCC
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MACMU|Ensembl=ENSMMUG00000004994|UniProtKB=F7ATP9	Syntaxin-7	ISS	10321247	PubMed	PTHR19957:SF90	SYNTAXIN-7
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	PHYIT|EnsemblGenome=PITG_06376|UniProtKB=D0N4Q3	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta, putative	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	MOUSE|MGI=MGI=95698|UniProtKB=P47856	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1	ISS			PTHR10937:SF2	GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE  ISOMERIZING  1
P05918	p38 MAPK pathway	P06015	p38gamma	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00006	Apoptosis signaling pathway	P00272	ASK1	BOVIN|Ensembl=ENSBTAG00000009065|UniProtKB=F1MXH6	Uncharacterized protein	ISS	8974401	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00830	Lipoxygenase	MACMU|Gene=ALOX5AP|UniProtKB=P30354	Arachidonate 5-lipoxygenase-activating protein (Fragment)	ISS	11937571	PubMed	PTHR10250:SF2	ARACHIDONATE 5-LIPOXYGENASE-ACTIVATING PROTEIN
P00034	Integrin signalling pathway	P00937	Vinculin	CHICK|Gene=VCL|UniProtKB=P12003	Vinculin	IPI	14702644	PubMed	PTHR18914:SF1	VINCULIN
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	RAT|RGD=1597195|UniProtKB=D4A9J2	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00020	FAS signaling pathway	P00594	Caspase8	MACMU|Ensembl=ENSMMUG00000031296|UniProtKB=F7C587	Uncharacterized protein	ISS	11917123	PubMed	PTHR10454:SF162	CASPASE-8
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ARATH|TAIR=AT3G18780|UniProtKB=Q96292	Actin-2	IDA			PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	CHICK|Gene=PSEN2|UniProtKB=Q90X07	Presenilin-2	IDA	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00018	EGF receptor signaling pathway	P00547	PP2A	XENTR|Xenbase=XB-GENE-957526|UniProtKB=K9J7P6	Uncharacterized protein	ISS	8703017	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P04395	Vasopressin synthesis	P04593	Glycopeptide	BOVIN|Ensembl=ENSBTAG00000008026|UniProtKB=P01175	Oxytocin-neurophysin 1	IC	6717565	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00021	FGF signaling pathway	P00635	FRS2	XENTR|Xenbase=XB-GENE-479760|UniProtKB=B5DE89	Frs2 protein	ISS	21826201	PubMed	PTHR21258:SF40	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2
P00019	Endothelin signaling pathway	P00568	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IGI	2837282	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MOUSE|MGI=MGI=99842|UniProtKB=Q02284	5-hydroxytryptamine receptor 1F	ISS	12441358	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00647	SHP2	MONDO|Ensembl=ENSMODG00000003120|UniProtKB=F6WVD2	Tyrosine-protein phosphatase non-receptor type	ISS	95163101	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00053	T cell activation	P01332	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IDA	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00906	Rap1	MACMU|Ensembl=ENSMMUG00000014486|UniProtKB=F7GH95	Ras-related protein Rap-1A	ISS	10476970	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	PANTR|Ensembl=ENSPTRG00000018449|UniProtKB=H2QTG5	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00057	Wnt signaling pathway	P01457	GBeta	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00780	Microtubule	PANTR|Ensembl=ENSPTRG00000017674|UniProtKB=H2Q189	Uncharacterized protein	IDA	12932731	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8714|UniProtKB=Q9Y5F8	Protocadherin gamma-B7	IDA	8120095	PubMed	PTHR24028:SF113	PROTOCADHERIN GAMMA-B7
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00053	T cell activation	P01312	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00034	Integrin signalling pathway	P00912	Arp2/3	CHICK|Ensembl=ENSGALG00000004693|UniProtKB=Q5ZJI7	Uncharacterized protein	ISS	12473693	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00019	Endothelin signaling pathway	P00586	Gq	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=98962|UniProtKB=P28047	Protein Wnt-7b	IDA	8717036	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02723	Adenine and hypoxanthine salvage pathway	P02812	Deoxyinosine phosphorylase	MOUSE|MGI=MGI=97365|UniProtKB=P23492	Purine nucleoside phosphorylase	ISS	7903568	PubMed	PTHR11904:SF12	PURINE NUCLEOSIDE PHOSPHORYLASE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	DROME|FlyBase=FBgn0264000|UniProtKB=M9PHV5	Glutamate receptor IB, isoform B	IC	12446127	PubMed	PTHR18966:SF270	GLUTAMATE RECEPTOR 1-RELATED
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00010	B cell activation	P00398	IP3R	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	IGI	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05970	TH	HUMAN|HGNC=11782|UniProtKB=P07101	Tyrosine 3-monooxygenase	ISS	12480184	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00010	B cell activation	P00376	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	HUMAN|HGNC=712|UniProtKB=P32121	Beta-arrestin-2	IDA	11742073	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	IC	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00057	Wnt signaling pathway	P01465	Ggamma	BOVIN|Ensembl=ENSBTAG00000003043|UniProtKB=P63212	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00562	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	IPI	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	CANLF|Ensembl=ENSCAFG00000006453|UniProtKB=F6X958	Serine/threonine-protein phosphatase	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MACMU|Ensembl=ENSMMUG00000012054|UniProtKB=F6TII3	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	PANTR|Ensembl=ENSPTRG00000012427|UniProtKB=H2QIN7	Mitogen-activated protein kinase kinase kinase 2	ISS	8649450	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PRIPA|Gene=PPA21757|UniProtKB=H3FHL0	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	TAS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05913	Enkephalin release	P05974	G-Protein (i)	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	BOVIN|Ensembl=ENSBTAG00000011803|UniProtKB=F1MTZ2	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF427	MYOSIN-3
P00018	EGF receptor signaling pathway	P00545	JNK1-3	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IGI	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00029	Huntington disease	P00788	Calpain	MACMU|Ensembl=ENSMMUG00000012876|UniProtKB=F6SFW8	Uncharacterized protein	ISS	11675509	PubMed	PTHR10183:SF322	CALPAIN-11
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00796	Kainate receptor	RAT|RGD=2732|UniProtKB=P22756	Glutamate receptor ionotropic, kainate 1	IDA	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00094	BACE-1 pro-domain	MACMU|Ensembl=ENSMMUG00000007785|UniProtKB=F7CQI1	Beta-secretase 1 isoform A preproprotein	ISS	10531052	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=69426|UniProtKB=P34975	Kappa-type opioid receptor	IDA	11259487	PubMed	PTHR24229:SF1	KAPPA-TYPE OPIOID RECEPTOR
P06959	CCKR signaling map	G06993	TFF1	HUMAN|HGNC=11755|UniProtKB=P04155	Trefoil factor 1	RCA	12891554	PubMed	PTHR13826:SF18	TREFOIL FACTOR 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	BOVIN|Gene=SLC18A2|UniProtKB=Q27963	Synaptic vesicular amine transporter	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CANLF|Ensembl=ENSCAFG00000019807|UniProtKB=F2Z4P1	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00012	Cadherin signaling pathway	P00470	F-actin	MOUSE|MGI=MGI=87904|UniProtKB=P60710	Actin, cytoplasmic 1	IC	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=1921305|UniProtKB=Q8K4S1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	7822322	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00056	VEGF signaling pathway	P01412	HSP27	CANLF|Ensembl=ENSCAFG00000010584|UniProtKB=P68280	Alpha-crystallin A chain	ISS			PTHR11527:SF36	ALPHA-CRYSTALLIN A CHAIN
P05913	Enkephalin release	G06046	preproenkephalin mRNA	DANRE|ZFIN=ZDB-GENE-030729-31|UniProtKB=A8E7S2	Uncharacterized protein	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	MOUSE|MGI=MGI=1351342|UniProtKB=Q3UVX5	Metabotropic glutamate receptor 5	ISS	7476890	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	IXOSC|EnsemblGenome=ISCW003614|UniProtKB=B7PHY7	Cdc42 protein, putative	ISS	4757952	gi	PTHR24072:SF192	CDC42 HOMOLOG
P05731	GABA-B receptor II signaling	P05754	Ggamma	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01446	Calcineurin	DICDI|dictyBase=DDB_G0267446|UniProtKB=Q55G87	Calcineurin subunit B type 1	IDA	12015605	PubMed	PTHR23056:SF4	PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1
P00053	T cell activation	P01306	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	87226391	PubMed	PTHR24070:SF385	GTPASE HRAS
P00006	Apoptosis signaling pathway	P00274	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=12789|UniProtKB=Q93098	Protein Wnt-8b	IDA	11266476	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00046	Oxidative stress response	P01135	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	TAS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IDA	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	MACMU|Ensembl=ENSMMUG00000015658|UniProtKB=F7AJI7	Uncharacterized protein	ISS	11081635	PubMed	PTHR15071:SF17	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01202	p85	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	IDA	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00053	T cell activation	P01314	nck	MACMU|Ensembl=ENSMMUG00000001390|UniProtKB=F7D094	Uncharacterized protein	ISS	12874226	PubMed	PTHR44108:SF1	CYTOPLASMIC PROTEIN NCK2
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	PANTR|Gene=ALDOA|UniProtKB=A5A6I5	Fructose-bisphosphate aldolase A	ISS	6086339	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	91298951	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01420	FAK	RAT|RGD=3443|UniProtKB=O35346	Focal adhesion kinase 1	ISS	9182576	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00007	Axon guidance mediated by semaphorins	P00332	Fes	RAT|RGD=1564385|UniProtKB=D4A584	Tyrosine-protein kinase	ISS			PTHR24418:SF197	TYROSINE-PROTEIN KINASE FES/FPS
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00005	Angiogenesis	P00191	TF	HUMAN|HGNC=3541|UniProtKB=P13726	Tissue factor	IGI	8779717	PubMed	PTHR20859:SF22	TISSUE FACTOR
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	BOVIN|Ensembl=ENSBTAG00000010402|UniProtKB=F1MQ37	Uncharacterized protein	ISS			PTHR13140:SF317	MYOSIN-9
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00048	PI3 kinase pathway	P01199	Galpha	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000002016|UniProtKB=F1P3G1	Protein kinase C delta type	ISS	11880265	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00030	Hypoxia response via HIF activation	P00814	P300	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00117	E-cadherin C-terminal fragment	PANTR|Ensembl=ENSPTRG00000008269|UniProtKB=H2QBE4	Cadherin 3, type 1, P-cadherin (Placental)	ISS	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	PANTR|Ensembl=ENSPTRG00000001790|UniProtKB=H2Q0T3	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF34	REGULATOR OF G-PROTEIN SIGNALING 1
P00059	p53 pathway	G04694	p110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	8327893	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	HUMAN|HGNC=6264|UniProtKB=P48549	G protein-activated inward rectifier potassium channel 1	ISS	2433589	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06846	SP1	MOUSE|MGI=MGI=98372|UniProtKB=O89090	Transcription factor Sp1	RCA			PTHR23235:SF16	TRANSCRIPTION FACTOR SP1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MOUSE|MGI=MGI=95823|UniProtKB=Q03391	Glutamate receptor ionotropic, NMDA 2D	IC	11554549	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9836512	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00912	Arp2/3	RAT|RGD=1305848|UniProtKB=P85970	Actin-related protein 2/3 complex subunit 2	ISS	17943202	gi	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	RAT|RGD=2734|UniProtKB=Q01812	Glutamate receptor ionotropic, kainate 4	ISS	12871085	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT4G36450|UniProtKB=O23236	Mitogen-activated protein kinase 14	ISS	10514528	PubMed	PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P02744	Fructose galactose metabolism	P02965	UDP Glucose 4 epimerase	ECOLI|EcoGene=EG10362|UniProtKB=P09147	UDP-glucose 4-epimerase	RCA			PTHR43725:SF8	UDP-GLUCOSE 4-EPIMERASE
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00057	Wnt signaling pathway	P01463	Kremen	HUMAN|HGNC=18797|UniProtKB=Q8NCW0	Kremen protein 2	ISS			PTHR24269:SF15	KREMEN PROTEIN 2
P00049	Parkinson disease	P01227	20S proteasome	RAT|RGD=61849|UniProtKB=P60901	Proteasome subunit alpha type-6	TAS	12859888	PubMed	PTHR11599:SF11	PROTEASOME SUBUNIT ALPHA TYPE-6
P04393	Ras Pathway	P04567	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	DANRE|ZFIN=ZDB-GENE-050417-441|UniProtKB=Q567Y8	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04611	P300	PANTR|Ensembl=ENSPTRG00000014418|UniProtKB=H2QLS0	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	HUMAN|HGNC=6025|UniProtKB=P10145	Interleukin-8	ISS	124361	gi	PTHR10179:SF70	INTERLEUKIN-8
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00029	Huntington disease	P00805	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00470	F-actin	DICPU|Gene=DICPUDRAFT_90232|UniProtKB=F1A175	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04396	Vitamin D metabolism and pathway	P04602	RXR	RAT|RGD=3534|UniProtKB=A0A0G2JW78	Protein Rara	TAS			PTHR24082:SF115	RETINOIC ACID RECEPTOR ALPHA
P00045	Notch signaling pathway	P01108	Nicastrin	MACMU|Ensembl=ENSMMUG00000021856|UniProtKB=F7EHX8	Nicastrin	ISS	10993067	PubMed	PTHR21092:SF0	NICASTRIN
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	MACMU|Ensembl=ENSMMUG00000012305|UniProtKB=F7DLC9	Tyrosine-protein kinase receptor	ISS	2877871	PubMed	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00003	Alzheimer disease-amyloid secretase pathway	P00107	kinesin	MOUSE|MGI=MGI=107953|UniProtKB=O88448	Kinesin light chain 2	IDA	11740561	PubMed	PTHR19959:SF177	KINESIN LIGHT CHAIN 2
P00010	B cell activation	P00379	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P06959	CCKR signaling map	P07114	JUN	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	RCA	7935387	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00019	Endothelin signaling pathway	P00572	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00896	Insulin IGF	DANRE|ZFIN=ZDB-GENE-030131-2935|UniProtKB=Q8JIE4	Insulin-like growth factor 2	ISS	4504609	gi	PTHR11454:SF10	INSULIN-LIKE GROWTH FACTOR II
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	RAT|RGD=62029|UniProtKB=P02563	Myosin-6	IEP	10938134	PubMed	PTHR13140:SF721	MYOSIN-6
P00018	EGF receptor signaling pathway	P00548	RKIP	ARATH|TAIR=AT2G27550|UniProtKB=Q9ZNV5	Protein CENTRORADIALIS-like	ISS			PTHR11362:SF48	PROTEIN CENTRORADIALIS-LIKE
P00008	Axon guidance mediated by Slit/Robo	P00352	DCC	MACMU|Ensembl=ENSMMUG00000013999|UniProtKB=F6RRI0	Uncharacterized protein	ISS	8861902	PubMed	PTHR44146:SF3	NETRIN RECEPTOR DCC
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	MACMU|Ensembl=ENSMMUG00000010542|UniProtKB=F7D0L2	Segment polarity protein dishevelled homolog DVL-2	ISS	11212302	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	MOUSE|MGI=MGI=109482|UniProtKB=P97445	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	14507926	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	HUMAN|HGNC=145|UniProtKB=P63267	Actin, gamma-enteric smooth muscle	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P05730	Endogenous cannabinoid signaling	P05746	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000001161|UniProtKB=F6RHW4	Uncharacterized protein	ISS	10908612	PubMed	PTHR21230:SF39	VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00049	Parkinson disease	P01238	14-3-3	CANLF|Ensembl=ENSCAFG00000013549|UniProtKB=E2QVP6	Uncharacterized protein	ISS	91108808	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00547	PP2A	ARATH|TAIR=AT3G09880|UniProtKB=O04376	Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' beta isoform	ISS			PTHR10257:SF3	PP2A-B', ISOFORM B
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00034	Integrin signalling pathway	P00911	B-Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00057	Wnt signaling pathway	P01470	Frodo	HUMAN|HGNC=17748|UniProtKB=Q9NYF0	Dapper homolog 1	TAS			PTHR15919:SF12	DAPPER HOMOLOG 1
P00048	PI3 kinase pathway	P01179	PKB	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	TAS	12719720	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00011	Blood coagulation	P00415	Plasmin	RAT|RGD=619893|UniProtKB=Q01177	Plasminogen	ISS	11928811	PubMed	PTHR24261:SF5	PLASMINOGEN
P00012	Cadherin signaling pathway	P00474	Wnt	CAEEL|WormBase=WBGene00000858|UniProtKB=P34889	Protein Wnt-2	IDA	8717036	PubMed	PTHR12027:SF77	PROTEIN WNT-5
P00010	B cell activation	P00380	fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	TAS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DANRE|ZFIN=ZDB-GENE-000322-1|UniProtKB=Q9I8V1	Actin, alpha 1, skeletal muscle	IDA	10974003	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Gene=SSTR2|UniProtKB=P34993	Somatostatin receptor type 2	ISS	12181435	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P00047	PDGF signaling pathway	P01145	c-fos	RAT|RGD=2626|UniProtKB=P12841	Proto-oncogene c-Fos	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00009	Axon guidance mediated by netrin	P00363	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	IGI	10514528	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P05916	Opioid prodynorphin pathway	P06002	G-protein	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	RAT|RGD=619965|UniProtKB=P26769	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P06587	Nicotine pharmacodynamics pathway	P06608	DDC	RAT|RGD=2494|UniProtKB=P14173	Aromatic-L-amino-acid decarboxylase	TAS	107930	OMIM	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	RAT|RGD=628852|UniProtKB=Q02294	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	14624853	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00021	FGF signaling pathway	P00633	Ras	MONDO|Ensembl=ENSMODG00000025248|UniProtKB=F7F5X1	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01465	Ggamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95809|UniProtKB=P23819	Glutamate receptor 2	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P04393	Ras Pathway	P04552	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00048	PI3 kinase pathway	P01202	p85	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=88356|UniProtKB=P10287	Cadherin-3	IDA	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P00059	p53 pathway	P04618	PML	HUMAN|HGNC=9113|UniProtKB=P29590	Protein PML	IDA	14992722	PubMed	PTHR45211:SF1	PROTEIN PML
P02746	Heme biosynthesis	P02982	Protoheme IX farnesyl transferase	ARATH|TAIR=AT2G44520|UniProtKB=O64886	Protoheme IX farnesyltransferase, mitochondrial	ISS			PTHR43448:SF2	PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=1930705|UniProtKB=P61264	Syntaxin-1B	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00005	Angiogenesis	P00185	JAK1	PANTR|Ensembl=ENSPTRG00000000825|UniProtKB=H2PZ66	Tyrosine-protein kinase	ISS	9637709	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00029	Huntington disease	P00775	Rac	CAEBR|Gene=CBG13013|UniProtKB=A8XGW3	Protein CBR-CDC-42	ISS			PTHR24072:SF192	CDC42 HOMOLOG
P00049	Parkinson disease	P01230	Src kinase	PANTR|Ensembl=ENSPTRG00000020263|UniProtKB=H2R453	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000011757|UniProtKB=Q9XT97	Presenilin-1	IDA	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P05731	GABA-B receptor II signaling	P05754	Ggamma	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00006	Apoptosis signaling pathway	P00260	AKT	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	ISS	12655147	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00567	PKG	PANTR|Ensembl=ENSPTRG00000002509|UniProtKB=H2Q1X0	cGMP-dependent protein kinase	ISS	14568994	PubMed	PTHR24353:SF68	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00203	Erk	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=11433|UniProtKB=Q16623	Syntaxin-1A	ISS	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P04395	Vasopressin synthesis	P04593	Glycopeptide	BOVIN|Ensembl=ENSBTAG00000008026|UniProtKB=P01175	Oxytocin-neurophysin 1	IC	9756087	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00021	FGF signaling pathway	P00623	FGF	MOUSE|MGI=MGI=1202401|UniProtKB=P63075	Fibroblast growth factor 17	ISS	9514906	PubMed	PTHR11486:SF71	FIBROBLAST GROWTH FACTOR 17
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	RAT|RGD=620465|UniProtKB=O08565	C-X-C chemokine receptor type 4	ISS	11591799	PubMed	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P00019	Endothelin signaling pathway	P00591	PLCbeta	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00010	B cell activation	P00384	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00057	Wnt signaling pathway	P01451	Galpha	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	PANTR|Ensembl=ENSPTRG00000020210|UniProtKB=Q5IS76	Neuronal acetylcholine receptor subunit alpha-6	ISS	15155845	PubMed	PTHR18945:SF82	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-6
P02723	Adenine and hypoxanthine salvage pathway	P02812	Deoxyinosine phosphorylase	MYCTU|EnsemblGenome=Rv3307|UniProtKB=P9WP01	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	HUMAN|HGNC=4594|UniProtKB=Q14416	Metabotropic glutamate receptor 2	ISS	20012997	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05916	Opioid prodynorphin pathway	P06002	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05731	GABA-B receptor II signaling	P05752	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00471	Cadherin	BOVIN|Ensembl=ENSBTAG00000018179|UniProtKB=F1MEC8	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF46	PROTOCADHERIN-8
P02738	De novo purine biosynthesis	P02902	ADP reductase	THEMA|EnsemblGenome=TM_0118|UniProtKB=G4FH33	Ribonucleotide reductase of class II (Coenzyme B12-dependent)	ISS			PTHR43371:SF1	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00587	Raf-1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01448	CBP	CAEEL|WormBase=WBGene00010545|UniProtKB=G5EBG3	CBP/p300 homolog	ISS	8413673	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00034	Integrin signalling pathway	P00925	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IDA	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00059	p53 pathway	G01579	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	IC	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02776	Serine glycine biosynthesis	P03159	Phosphoserine phosphatase	BOVIN|Ensembl=ENSBTAG00000013081|UniProtKB=Q2KHU0	Phosphoserine phosphatase	ISS			PTHR43344:SF2	PHOSPHOSERINE PHOSPHATASE
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IDA	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00093	Tip60	BOVIN|Ensembl=ENSBTAG00000008877|UniProtKB=F1MYC3	Uncharacterized protein	ISS			PTHR12345:SF14	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PHYIT|EnsemblGenome=PITG_00156|UniProtKB=D0MT13	Beta-tubulin	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00047	PDGF signaling pathway	P01148	Grb2	HUMAN|HGNC=14458|UniProtKB=Q9UQC2	GRB2-associated-binding protein 2	ISS			PTHR12156:SF4	GRB2-ASSOCIATED-BINDING PROTEIN 2
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000002016|UniProtKB=F1P3G1	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BOVIN|Ensembl=ENSBTAG00000010820|UniProtKB=F1N4C0	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P04393	Ras Pathway	P04556	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IDA	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05918	p38 MAPK pathway	P06031	p38alpha	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	RCA	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00059	p53 pathway	G04700	PAI	CANLF|Ensembl=ENSCAFG00000013909|UniProtKB=F1PUI4	Uncharacterized protein	ISS	1709561	gi	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00047	PDGF signaling pathway	P01164	PDK1/2	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	ISS	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=1921305|UniProtKB=Q8K4S1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	15611108	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P05918	p38 MAPK pathway	P05919	MAPKAP-K3	PANTR|Ensembl=ENSPTRG00000014968|UniProtKB=H2QMP5	Mitogen-activated protein kinase-activated protein kinase 3	ISS	11157753	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P00037	Ionotropic glutamate receptor pathway	P00998	stargazin	MACMU|Ensembl=ENSMMUG00000031026|UniProtKB=F6QST9	Voltage-dependent calcium channel gamma subunit	RCA			PTHR12107:SF1	VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-2 SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04380	Cortocotropin releasing factor receptor signaling pathway	P04453	ACTH	DANRE|ZFIN=ZDB-GENE-030513-2|UniProtKB=Q7ZT18	Pro-opiomelanocortin protein	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00021	FGF signaling pathway	P00623	FGF	RAT|RGD=71068|UniProtKB=Q9EST9	Fibroblast growth factor 20	IGI	11032730	PubMed	PTHR11486:SF72	FIBROBLAST GROWTH FACTOR 20
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00005	Angiogenesis	P00189	Fzd	DANRE|ZFIN=ZDB-GENE-990415-218|UniProtKB=B3DIG4	Frizzled homolog 8c	ISS	11212302	PubMed	PTHR11309:SF126	FRIZZLED-5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	IDA	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00046	Oxidative stress response	P01129	JNK1/2	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	TAS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	ARATH|TAIR=AT4G25280|UniProtKB=Q6NMK6	Probable UMP-CMP kinase 2	ISS			PTHR23359:SF118	UMP-CMP KINASE 2-RELATED
P00059	p53 pathway	G04691	IGF-BP3	RAT|RGD=2874|UniProtKB=P15473	Insulin-like growth factor-binding protein 3	ISS			PTHR11551:SF3	INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 3
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	DROME|FlyBase=FBgn0031781|UniProtKB=Q9VMH2	Actin-related protein 2/3 complex subunit 4	ISS	5031595	gi	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00011	Blood coagulation	P00453	FXIII	RAT|RGD=621495|UniProtKB=O08619	Coagulation factor XIII A chain	ISS	11067435	gi	PTHR11590:SF42	COAGULATION FACTOR XIII A CHAIN
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	ANOGA|EnsemblGenome=AGAP009734|UniProtKB=Q5TP56	Protein Wnt	TAS	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00005	Angiogenesis	P00237	FRP	PANTR|Ensembl=ENSPTRG00000020122|UniProtKB=H2QVZ0	Uncharacterized protein	ISS	12549854	PubMed	PTHR11309:SF22	FRIZZLED-3
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	MYCTU|EnsemblGenome=Rv1383|UniProtKB=P9WPK5	Carbamoyl-phosphate synthase small chain	ISS			PTHR11405:SF4	CARBAMOYL-PHOSPHATE SYNTHASE ARGININE-SPECIFIC SMALL CHAIN
P00006	Apoptosis signaling pathway	P00282	IGFR2	MOUSE|MGI=MGI=96435|UniProtKB=Q07113	Cation-independent mannose-6-phosphate receptor	IDA	13642251	gi	PTHR15071:SF17	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
P00006	Apoptosis signaling pathway	P00269	MAPK	ORYSJ|EnsemblGenome=OS06G0699400|UniProtKB=Q5Z859	Mitogen-activated protein kinase 4	ISS	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	LEIMA|Gene=LmjF06.0860|UniProtKB=P07382	Bifunctional dihydrofolate reductase-thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	HALSA|EnsemblGenome=VNG_0006G|UniProtKB=Q9HT00	Glutamine--fructose-6-phosphate aminotransferase [isomerizing]	ISS			PTHR10937:SF0	GH12731P-RELATED
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	ANOGA|EnsemblGenome=AGAP000801|UniProtKB=F5HJZ1	AGAP000801-PB (Fragment)	IC	12941441	PubMed	PTHR18966:SF352	GLUTAMATE RECEPTOR FAMILY  AMPA
P00049	Parkinson disease	P01232	CASK	CHICK|Ensembl=ENSGALG00000016226|UniProtKB=E1BWL4	Uncharacterized protein	ISS	11679592	PubMed	PTHR23122:SF40	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	HUMAN|HGNC=3023|UniProtKB=P14416	D(2) dopamine receptor	IDA	11248120	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	MOUSE|MGI=MGI=106217|UniProtKB=Q61290	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	11976940	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00034	Integrin signalling pathway	P00936	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	IPI	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P00018	EGF receptor signaling pathway	P00560	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01200	SHIP	MACMU|Ensembl=ENSMMUG00000010451|UniProtKB=F7CRA7	Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2	ISS	9824312	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01421	Rac	PANTR|Ensembl=ENSPTRG00000003550|UniProtKB=H2Q3I0	Rho GTPase activating protein 1	ISS			PTHR23176:SF28	RHO GTPASE-ACTIVATING PROTEIN 1
P00021	FGF signaling pathway	P00648	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IGI	3755548	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04398	p53 pathway feedback loops 2	G04714	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00048	PI3 kinase pathway	P01202	p85	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00060	Ubiquitin proteasome pathway	P01491	E2	PHYPA|Gene=PHYPADRAFT_105371|UniProtKB=A9RXP4	Predicted protein	ISS			PTHR24068:SF55	UBIQUITIN-CONJUGATING ENZYME E2 11-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00005	Angiogenesis	P00191	TF	BOVIN|Ensembl=ENSBTAG00000007101|UniProtKB=P30931	Tissue factor	ISS	401175	gi	PTHR20859:SF22	TISSUE FACTOR
P00056	VEGF signaling pathway	P01419	Ets	ORNAN|Ensembl=ENSOANG00000012104|UniProtKB=F7FH70	Uncharacterized protein	ISS	3284179	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00036	Interleukin signaling pathway	P00977	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00018	EGF receptor signaling pathway	P00547	PP2A	XENTR|Xenbase=XB-GENE-957248|UniProtKB=Q6GLE6	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00010	B cell activation	P00381	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	IGI	12068308	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P04393	Ras Pathway	P04570	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	TAS	12736250	PubMed	PTHR10202:SF18	PRESENILIN-1
P00006	Apoptosis signaling pathway	P00269	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00034	Integrin signalling pathway	P00951	Jnk	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	IDA	7600581	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=12775|UniProtKB=O00744	Protein Wnt-10b	TAS	12549854	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MOUSE|MGI=MGI=95822|UniProtKB=Q01098	Glutamate receptor ionotropic, NMDA 2C	ISS	14698601	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	MOUSE|MGI=MGI=1339975|UniProtKB=O88643	Serine/threonine-protein kinase PAK 1	ISS	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P05918	p38 MAPK pathway	P06040	MSK1	RAT|RGD=1308336|UniProtKB=A0A0G2K366	Ribosomal protein S6 kinase	ISS	9687510	PubMed	PTHR24351:SF115	RIBOSOMAL PROTEIN S6 KINASE ALPHA-5
P00047	PDGF signaling pathway	P01148	Grb2	BOVIN|Ensembl=ENSBTAG00000002922|UniProtKB=F1MFX6	Uncharacterized protein	ISS			PTHR12156:SF4	GRB2-ASSOCIATED-BINDING PROTEIN 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	IC	14698601	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Gene=DRD2|UniProtKB=P20288	D(2) dopamine receptor	IDA	11861492	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00049	Parkinson disease	P01238	14-3-3	NEUCR|EnsemblGenome=EFNCRG00000002359|UniProtKB=Q7RVK6	14-3-3 family protein 7	ISS	12063166	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00057	Wnt signaling pathway	P01443	Phospholipase C	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	XENTR|Xenbase=XB-GENE-1011906|UniProtKB=F6XPD5	Uncharacterized protein (Fragment)	ISS			PTHR11824:SF8	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MACMU|Ensembl=ENSMMUG00000015916|UniProtKB=F7AT89	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF401	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4
P00013	Cell cycle	P00485	Cdk2	HUMAN|HGNC=23789|UniProtKB=Q9BW66	Cyclin-dependent kinase 2-interacting protein	ISS	12477932	PubMed	PTHR15827:SF2	CYCLIN-DEPENDENT KINASE 2-INTERACTING PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=98955|UniProtKB=P17553	Proto-oncogene Wnt-3	TAS	11266476	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=280|UniProtKB=P25100	Alpha-1D adrenergic receptor	IDA			PTHR24248:SF14	ALPHA-1D ADRENERGIC RECEPTOR
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	20010089	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	8787761	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00635	FRS2	MOUSE|MGI=MGI=1100860|UniProtKB=Q8C180	Fibroblast growth factor receptor substrate 2	ISS	12571252	PubMed	PTHR21258:SF40	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	ANOGA|EnsemblGenome=AGAP001478|UniProtKB=Q7PXM3	AGAP001478-PA	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00018	EGF receptor signaling pathway	P00546	GAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00005	Angiogenesis	P00236	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00565	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MACMU|Ensembl=ENSMMUG00000017374|UniProtKB=F7H6T7	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000005792|UniProtKB=F6VTR8	Uncharacterized protein	ISS	129387	gi	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000035697|UniProtKB=Q28024	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IDA	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	18021322	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	HUMAN|HGNC=7555|UniProtKB=P12524	Protein L-Myc	IEP	12356903	PubMed	PTHR11514:SF1	PROTEIN L-MYC-RELATED
P00049	Parkinson disease	P01219	SAPK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00053	T cell activation	P01311	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00925	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	RCA	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00181	SHP2	RAT|RGD=620660|UniProtKB=P81718	Tyrosine-protein phosphatase non-receptor type 6	ISS			PTHR19134:SF65	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 6
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	HUMAN|HGNC=2510|UniProtKB=P26232	Catenin alpha-2	TAS	1768802	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P00034	Integrin signalling pathway	P00907	ERK	RAT|RGD=62087|UniProtKB=P27704	Mitogen-activated protein kinase 6	ISS	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	PSEAE|EnsemblGenome=PA0546|UniProtKB=Q9I5Z0	S-adenosylmethionine synthase	ISS			PTHR11964:SF1	S-ADENOSYLMETHIONINE SYNTHASE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	BOVIN|Ensembl=ENSBTAG00000005464|UniProtKB=E1B9K3	Uncharacterized protein	ISS	10978539	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MACMU|Ensembl=ENSMMUG00000018568|UniProtKB=F6YLW2	Uncharacterized protein	ISS	8621389	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MACMU|Ensembl=ENSMMUG00000007263|UniProtKB=F7FGG2	Preproendothelin-1	ISS	15117818	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P00012	Cadherin signaling pathway	P00475	Frizzled	BOVIN|Ensembl=ENSBTAG00000007047|UniProtKB=A3KMX5	FZD10 protein	ISS	11212302	PubMed	PTHR11309:SF86	FRIZZLED-10
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	MOUSE|MGI=MGI=2653900|UniProtKB=Q8BH00	Aldehyde dehydrogenase family 8 member A1	IC			PTHR43720:SF2	ALDEHYDE DEHYDROGENASE FAMILY 8 MEMBER A1
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ORYSJ|Gene=Os01g0866100|UniProtKB=P0C540	Actin-7	ISS	10974003	PubMed	PTHR11937:SF205	SUBFAMILY NOT NAMED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	RCA	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00023	General transcription regulation	P00658	TBP-associated factors	CAEEL|WormBase=WBGene00006389|UniProtKB=Q9NEW8	TAF (TBP-associated transcription factor) family	ISS			PTHR12228:SF0	TAF7 RNA POLYMERASE II, TATA BOX BINDING PROTEIN  TBP -ASSOCIATED FACTOR
P00048	PI3 kinase pathway	P01188	Gbetagamma	ANOGA|EnsemblGenome=AGAP005912|UniProtKB=Q7Q6D3	AGAP005912-PA	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	DANRE|ZFIN=ZDB-GENE-040116-1|UniProtKB=Q7ZUQ0	Actin related protein 2/3 complex, subunit 1A	ISS	12963527	gi	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04398	p53 pathway feedback loops 2	P04665	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05974	G-Protein (i)	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00010	B cell activation	P00385	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	14564011	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00049	Parkinson disease	P01209	19S proteasome	SCHPO|PomBase=SPAC607.05|UniProtKB=Q9US13	Probable 26S proteasome regulatory subunit rpn9	TAS	12859888	PubMed	PTHR10539:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13
P00023	General transcription regulation	P00660	RNA Polymerase II	MONDO|Ensembl=ENSMODG00000005494|UniProtKB=F7BXN9	Uncharacterized protein	ISS			PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00021	FGF signaling pathway	P00638	PLCgamma	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00029	Huntington disease	P00774	Dynein complex	DROME|FlyBase=FBgn0026141|UniProtKB=O96860	Dynein light chain 2, cytoplasmic	IPI	9454836	PubMed	PTHR11886:SF35	DYNEIN LIGHT CHAIN 2, CYTOPLASMIC
P00036	Interleukin signaling pathway	P00990	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01443	Phospholipase C	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000024633|UniProtKB=F1MBU9	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P05730	Endogenous cannabinoid signaling	P05751	Galpha	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	3045562	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00034	Integrin signalling pathway	P00934	VASP	MACMU|Ensembl=ENSMMUG00000022938|UniProtKB=F6U702	Uncharacterized protein	ISS	8836115	PubMed	PTHR11202:SF12	VASODILATOR-STIMULATED PHOSPHOPROTEIN
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	SCHMA|EnsemblGenome=Smp_046600|UniProtKB=G4VLW2	Putative actin-1	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04393	Ras Pathway	P04578	Rho	MOUSE|MGI=MGI=107949|UniProtKB=P62746	Rho-related GTP-binding protein RhoB	ISS	13679859	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00018	EGF receptor signaling pathway	P00552	Ras	DICDI|dictyBase=DDB_G0292998|UniProtKB=P32252	Ras-like protein rasB	IGI	93205383	PubMed	PTHR24070:SF206	RAS-LIKE PROTEIN RASB
P00021	FGF signaling pathway	P00634	MEKK1-5	MACMU|Ensembl=ENSMMUG00000016376|UniProtKB=F7G2W1	Uncharacterized protein	ISS	8974401	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	RAT|RGD=2343|UniProtKB=P08483	Muscarinic acetylcholine receptor M3	ISS	11166329	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P05913	Enkephalin release	P05974	G-Protein (i)	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	IC	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00053	T cell activation	P01332	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01129	JNK1/2	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=3346|UniProtKB=P10688	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	7822322	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00646	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	227170	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	RCA	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01440	Cadherin	BOVIN|Ensembl=ENSBTAG00000019977|UniProtKB=F1N2W7	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF0	PROTOCADHERIN-10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	RCA	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04541	p90RSK	XENTR|Xenbase=XB-GENE-480947|UniProtKB=F6ZM17	Uncharacterized protein (Fragment)	ISS	6755374	gi	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DROME|FlyBase=FBgn0003093|UniProtKB=P13678	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00025	Hedgehog signaling pathway	P00691	CBP	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00029	Huntington disease	P00797	p53	MONDO|Ensembl=ENSMODG00000000554|UniProtKB=F6XLX5	Uncharacterized protein	ISS			PTHR12195:SF2	CYTOPLASMIC FMR1-INTERACTING PROTEIN 1
P00046	Oxidative stress response	P01135	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CAEEL|WormBase=WBGene00003774|UniProtKB=G5EGQ9	NMDA class glutamate Receptor	IC	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	3755548	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00005	Angiogenesis	P00223	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	PANTR|Ensembl=ENSPTRG00000014760|UniProtKB=H2QMB3	Serine/threonine-protein kinase receptor	ISS	11252892	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	MACMU|Ensembl=ENSMMUG00000013637|UniProtKB=F7GL52	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00018	EGF receptor signaling pathway	P00564	Rac	DICDI|dictyBase=DDB_G0282365|UniProtKB=P34146	Rho-related protein rac1C	IGI	4757952	gi	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=1930705|UniProtKB=P61264	Syntaxin-1B	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	MACMU|Ensembl=ENSMMUG00000014626|UniProtKB=F7GNE5	Uncharacterized protein	ISS			PTHR42884:SF13	NEUROENDOCRINE CONVERTASE 2
P00010	B cell activation	P00397	IKK	MACMU|Ensembl=ENSMMUG00000008351|UniProtKB=F7HRV5	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00047	PDGF signaling pathway	P01171	PLCgamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	PANTR|Ensembl=ENSPTRG00000033819|UniProtKB=H2QV00	Actin related protein 2/3 complex, subunit 1A, 41kDa	ISS	12932731	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	CAEBR|Gene=CBG02059|UniProtKB=A8WRW6	Protein CBR-UNC-2 (Fragment)	ISS	8386525	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	XENTR|Xenbase=XB-GENE-489222|UniProtKB=Q28GJ8	Ras homolog gene family, member A	ISS	10556059	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00049	Parkinson disease	P01207	PLD2	MACMU|Ensembl=ENSMMUG00000005666|UniProtKB=F6VWY6	Uncharacterized protein	ISS	9538008	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CAEEL|WormBase=WBGene00000955|UniProtKB=O76554	Acetylcholine receptor subunit alpha-type des-2	IC			PTHR18945:SF410	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-TYPE DES-2
P00047	PDGF signaling pathway	P01144	mTOR	DROME|FlyBase=FBgn0021796|UniProtKB=Q9VK45	Target of rapamycin	ISS	14526383	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DROME|FlyBase=FBgn0004623|UniProtKB=P29829	Guanine nucleotide-binding protein subunit beta-2	IC			PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00916	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g188289|UniProtKB=A7SCT6	Predicted protein	ISS	9753452	PubMed	PTHR23050:SF326	CALMODULIN
P00047	PDGF signaling pathway	P01168	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	7937853	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00021	FGF signaling pathway	P00642	MEK1-2	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	PANTR|Ensembl=ENSPTRG00000006510|UniProtKB=H2Q8K1	Presenilin	ISS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P02732	Coenzyme A linked carnitine metabolism	P02864	L-carnitine dehydratase	HUMAN|HGNC=16001|UniProtKB=Q9HAC7	Succinate--hydroxymethylglutarate CoA-transferase	ISS			PTHR43949:SF6	SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	DANRE|ZFIN=ZDB-GENE-990415-218|UniProtKB=B3DIG4	Frizzled homolog 8c	TAS	11212302	PubMed	PTHR11309:SF126	FRIZZLED-5
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000002647|UniProtKB=F7DIB7	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	CANLF|Ensembl=ENSCAFG00000015081|UniProtKB=E2RMT4	Uncharacterized protein	ISS	12473693	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	TAS	7600581	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	DROME|Gene=Dmel_CG7904|UniProtKB=A0A0B4KG59	Serine/threonine-protein kinase receptor	TAS	9395284	PubMed	PTHR23255:SF70	SERINE/THREONINE-PROTEIN KINASE RECEPTOR
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00638	PLCgamma	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Ensembl=ENSPTRG00000000543|UniProtKB=H2PYN8	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IGI	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05730	Endogenous cannabinoid signaling	P05751	Galpha	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PANTR|Ensembl=ENSPTRG00000006890|UniProtKB=H2Q943	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	MACMU|Ensembl=ENSMMUG00000013637|UniProtKB=F7GL52	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_127489|UniProtKB=C3XYC6	Putative uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04393	Ras Pathway	P04548	ATF2	CANLF|Ensembl=ENSCAFG00000013332|UniProtKB=F1PCQ4	Uncharacterized protein	ISS	10664585	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00010	B cell activation	P00385	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	IGI	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00053	T cell activation	P01311	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02749	Leucine biosynthesis	P03000	Branched chain amino acid aminotransferase	METJA|EnsemblGenome=MJ_1008|UniProtKB=Q58414	Putative branched-chain-amino-acid aminotransferase	ISS			PTHR42743:SF3	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE-LIKE PROTEIN 1-RELATED
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04393	Ras Pathway	P04557	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00005	Angiogenesis	P00206	Wnt	HUMAN|HGNC=12786|UniProtKB=O00755	Protein Wnt-7a	IEP	8717036	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P04393	Ras Pathway	P04541	p90RSK	PANTR|Ensembl=ENSPTRG00000022064|UniProtKB=H2QYE0	Uncharacterized protein	ISS	15632195	PubMed	PTHR24351:SF98	RIBOSOMAL PROTEIN S6 KINASE ALPHA-6
P00029	Huntington disease	P00805	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00807	Actin	PLAF7|EnsemblGenome=PF14_0124|UniProtKB=Q8ILW9	Actin-2	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	XENTR|Ensembl=ENSXETG00000021375|UniProtKB=F6T423	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00778	NMDA receptor	XENTR|Xenbase=XB-GENE-494200|UniProtKB=F7CS79	Uncharacterized protein	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00053	T cell activation	P01323	I kappa B	MACMU|Ensembl=ENSMMUG00000020374|UniProtKB=F6UMS2	NF-kappa-B inhibitor alpha	ISS	10811867	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00625	MKK3,6	RAT|RGD=620666|UniProtKB=Q925D6	Mitogen-activated protein kinase kinase 6	RCA			PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02787	Vitamin B6 metabolism	P03242	Threonine synthase	PSEAE|EnsemblGenome=PA3735|UniProtKB=P29363	Threonine synthase	ISS	10984043	PubMed	PTHR42690:SF1	THREONINE SYNTHASE-LIKE 2
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P01486	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P05915	Opioid proenkephalin pathway	P05994	G-protein	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	RAT|RGD=621060|UniProtKB=O88777	Presenilin-2	TAS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00040	Metabotropic glutamate receptor group II pathway	G01540	BDNF	CHICK|Ensembl=ENSGALG00000012163|UniProtKB=P25429	Brain-derived neurotrophic factor	ISS	11408619	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00012	Cadherin signaling pathway	P00462	Casein kinase II	CANLF|Ensembl=ENSCAFG00000006946|UniProtKB=E2RHZ1	Uncharacterized protein	ISS	10617630	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MOUSE|MGI=MGI=87906|UniProtKB=P63260	Actin, cytoplasmic 2	ISS	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P05913	Enkephalin release	P05972	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00048	PI3 kinase pathway	P01192	p110	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01443	Phospholipase C	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00018	EGF receptor signaling pathway	P00539	14-3-3	DAPPU|EnsemblGenome=DAPPUDRAFT_326737|UniProtKB=E9H8M4	Putative uncharacterized protein	ISS	97302963	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	CHICK|Ensembl=ENSGALG00000010273|UniProtKB=P48463	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	2461222	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00384	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	MONDO|Ensembl=ENSMODG00000016994|UniProtKB=F6QFD5	Uncharacterized protein	ISS			PTHR10024:SF115	SYNAPTOTAGMIN-11
P00017	DNA replication	P00527	Histones	THAPS|Gene=Thaps3183|UniProtKB=B5YMD6	Histone H3	ISS	12413958	PubMed	PTHR11426:SF169	HISTONE H3
P00006	Apoptosis signaling pathway	P00318	PKCs	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00029	Huntington disease	G01535	PIG3	MACMU|Ensembl=ENSMMUG00000001283|UniProtKB=F7BUD1	Quinone oxidoreductase PIG3 isoform 1	ISS	12932731	PubMed	PTHR43006:SF2	QUINONE OXIDOREDUCTASE PIG3
P00047	PDGF signaling pathway	P01173	STAT	DROME|FlyBase=FBgn0016917|UniProtKB=Q24151	Signal transducer and transcription activator	ISS			PTHR11801:SF43	SIGNAL TRANSDUCER AND TRANSCRIPTION ACTIVATOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Ensembl=ENSBTAG00000000914|UniProtKB=Q2KIP6	Kappa-type opioid receptor	ISS	11259498	PubMed	PTHR24229:SF1	KAPPA-TYPE OPIOID RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	11840290	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00200	Dsh	CAEEL|WormBase=WBGene00003241|UniProtKB=Q22227	Uncharacterized protein	ISS			PTHR10878:SF24	SUBFAMILY NOT NAMED
P00059	p53 pathway	G01580	p21	MOUSE|MGI=MGI=104556|UniProtKB=P39689	Cyclin-dependent kinase inhibitor 1	IGI	7774811	PubMed	PTHR10265:SF16	CYCLIN-DEPENDENT KINASE INHIBITOR 1
P04398	p53 pathway feedback loops 2	P04658	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	IGI	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MACMU|Ensembl=ENSMMUG00000017374|UniProtKB=F7H6T7	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	ORNAN|Ensembl=ENSOANG00000013961|UniProtKB=F6VPY1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04397	p53 pathway by glucose deprivation	P04639	AMPK	HUMAN|HGNC=9378|UniProtKB=Q9Y478	5'-AMP-activated protein kinase subunit beta-1	ISS			PTHR10343:SF16	5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04398	p53 pathway feedback loops 2	P04665	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04397	p53 pathway by glucose deprivation	P04640	p53	MACMU|Ensembl=ENSMMUG00000008639|UniProtKB=P56424	Cellular tumor antigen p53	TAS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00049	Parkinson disease	P01242	Casein kinase I	XENTR|Xenbase=XB-GENE-481480|UniProtKB=Q5XGI6	Casein kinase 1, epsilon	ISS	11865049	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00007	Axon guidance mediated by semaphorins	P00340	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12676940	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-041114-26|UniProtKB=F1RE11	Uncharacterized protein	ISS	2106672	PubMed	PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	RCA	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00018	EGF receptor signaling pathway	P00562	p38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	MOUSE|MGI=MGI=109284|UniProtKB=Q61144	Presenilin-2	IDA	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00052	TGF-beta signaling pathway	P01284	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04586	ProTRH (Pro Thyrotropin-releasing Hormone)	MOUSE|MGI=MGI=88390|UniProtKB=P01216	Glycoprotein hormones alpha chain	ISS			PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05923	beta-ARR2	RAT|RGD=2157|UniProtKB=P29067	Beta-arrestin-2	RCA	11742073	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	RAT|RGD=2740|UniProtKB=Q62645	Glutamate receptor ionotropic, NMDA 2D	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	9166716	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00057	Wnt signaling pathway	P01438	PP2A	MOUSE|MGI=MGI=1321161|UniProtKB=P62715	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01185	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05918	p38 MAPK pathway	P06013	ELK	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	RCA	11151091	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	BOVIN|Ensembl=ENSBTAG00000009778|UniProtKB=E1BMX0	Uncharacterized protein	ISS	99084794	PubMed	PTHR24070:SF186	GTPASE KRAS
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00034	Integrin signalling pathway	P00906	Rap1	DANRE|ZFIN=ZDB-GENE-040625-167|UniProtKB=Q6IQP4	RAP1A, member of RAS oncogene family	ISS	1904317	PubMed	PTHR24070:SF284	RAP1A, MEMBER OF RAS ONCOGENE FAMILY
P02726	Aminobutyrate degradation	P02825	4-aminobutyrate aminotransferase	YEAST|SGD=S000003251|UniProtKB=P17649	4-aminobutyrate aminotransferase	ISS	8133261	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P05916	Opioid prodynorphin pathway	P06002	G-protein	BOVIN|Ensembl=ENSBTAG00000003762|UniProtKB=A5PJS1	GNB5 protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00019	Endothelin signaling pathway	P00566	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	93028473	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00006	Apoptosis signaling pathway	P00270	Bcl-2	HUMAN|HGNC=990|UniProtKB=P10415	Apoptosis regulator Bcl-2	IDA	2250705	PubMed	PTHR11256:SF11	APOPTOSIS REGULATOR BCL-2
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01238	14-3-3	DROME|FlyBase=FBgn0020238|UniProtKB=P92177	14-3-3 protein epsilon	IDA	97302963	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	MONDO|Ensembl=ENSMODG00000015696|UniProtKB=F7E0Q7	Fructose-bisphosphate aldolase	ISS	74094688	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IGI	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04393	Ras Pathway	P04570	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	RAT|RGD=2736|UniProtKB=P35439	Glutamate receptor ionotropic, NMDA 1	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00029	Huntington disease	P00796	Kainate receptor	MOUSE|MGI=MGI=95818|UniProtKB=Q61626	Glutamate receptor ionotropic, kainate 5	IDA	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00010	B cell activation	P00402	Jnk	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00055	Transcription regulation by bZIP transcription factor	P01392	TFIIH complex	BOVIN|Gene=GTF2H3|UniProtKB=Q05B56	General transcription factor IIH subunit 3	ISS			PTHR12831:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	MOUSE|MGI=MGI=95816|UniProtKB=B1AS29	Glutamate receptor ionotropic, kainate 3	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00052	TGF-beta signaling pathway	P01284	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00475	Frizzled	MOUSE|MGI=MGI=1313278|UniProtKB=Q9R216	Frizzled-9	IDA	8717036	PubMed	PTHR11309:SF79	FRIZZLED-9
P00060	Ubiquitin proteasome pathway	P01491	E2	ASHGO|EnsemblGenome=AGOS_AER173C|UniProtKB=Q756T0	AER173Cp	ISS			PTHR24068:SF74	FI16911P1-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05731	GABA-B receptor II signaling	P05754	Ggamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00053	T cell activation	P01300	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00797	p53	HUMAN|HGNC=12003|UniProtKB=O15350	Tumor protein p73	TAS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00052	TGF-beta signaling pathway	P01275	P38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00057	Wnt signaling pathway	P01431	LRP5/6	PANTR|Ensembl=ENSPTRG00000004701|UniProtKB=H2Q5G9	Low density lipoprotein receptor-related protein 6	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	ORYSJ|EnsemblGenome=OS01G0282800|UniProtKB=Q43594	Tubulin beta-1 chain	ISS	9454836	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CANLF|Ensembl=ENSCAFG00000012181|UniProtKB=F2Z4N7	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	RAT|RGD=69319|UniProtKB=P54313	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00516	Ena/VASP	MACMU|Ensembl=ENSMMUG00000022938|UniProtKB=F6U702	Uncharacterized protein	ISS	8836115	PubMed	PTHR11202:SF12	VASODILATOR-STIMULATED PHOSPHOPROTEIN
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	CAEBR|Gene=CBG17948|UniProtKB=A8XSM9	Actin-related protein 2/3 complex subunit 4	ISS	5031595	gi	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	MOUSE|MGI=MGI=97852|UniProtKB=P62835	Ras-related protein Rap-1A	IDA	1904317	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00645	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00054	Toll receptor signaling pathway	P01375	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00047	PDGF signaling pathway	P01171	PLCgamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P02772	Pyruvate metabolism	P03136	Malic enzyme	YEAST|SGD=S000001512|UniProtKB=P36013	NAD-dependent malic enzyme, mitochondrial	ISS	8849441	PubMed	PTHR23406:SF34	MALIC ENZYME-RELATED
P00006	Apoptosis signaling pathway	P00298	Caspase 9	RAT|RGD=61867|UniProtKB=Q9JHK1	Caspase	ISS	9390557	PubMed	PTHR10454:SF157	CASPASE-9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00029	Huntington disease	P00799	JNK-2	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CHICK|Ensembl=ENSGALG00000011080|UniProtKB=O42402	Ornithokinin receptor	IDA	12130679	PubMed	PTHR24228:SF25	B2 BRADYKININ RECEPTOR
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00983	Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	IC	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MACMU|Ensembl=ENSMMUG00000009771|UniProtKB=F6ZHU6	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF681	MYOSIN-4
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00059	p53 pathway	P04620	TRAF	RAT|RGD=1310457|UniProtKB=B5DFH7	Protein Traf2	ISS			PTHR10131:SF21	TNF RECEPTOR-ASSOCIATED FACTOR 2
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02762	Pentose phosphate pathway	P03082	Transketolase	MOUSE|MGI=MGI=105992|UniProtKB=P40142	Transketolase	RCA			PTHR43195:SF3	TRANSKETOLASE
P00056	VEGF signaling pathway	P01421	Rac	BOVIN|Ensembl=ENSBTAG00000016501|UniProtKB=F6RWK1	Uncharacterized protein	ISS			PTHR23176:SF28	RHO GTPASE-ACTIVATING PROTEIN 1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00029	Huntington disease	P00796	Kainate receptor	CHICK|Ensembl=ENSGALG00000002098|UniProtKB=F1P0L4	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MACMU|Ensembl=ENSMMUG00000009679|UniProtKB=F6YBQ8	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	CHICK|Ensembl=ENSGALG00000005621|UniProtKB=F1NGS8	Uncharacterized protein	ISS	12888804	PubMed	PTHR43940:SF5	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00059	p53 pathway	P01486	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00049	Parkinson disease	P01226	CDCrel-1	HUMAN|HGNC=7729|UniProtKB=Q15019	Septin-2	IDA			PTHR18884:SF67	SEPTIN-2
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05913	Enkephalin release	P05974	G-Protein (i)	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	11956331	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	PANTR|Ensembl=ENSPTRG00000008768|UniProtKB=H2QC98	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF368	MYOSIN-8
P00025	Hedgehog signaling pathway	P00691	CBP	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	IC	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IDA	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00049	Parkinson disease	P01235	Fyn kinase	PANTR|Ensembl=ENSPTRG00000018521|UniProtKB=H2QTL3	Tyrosine-protein kinase	ISS			PTHR24418:SF296	TYROSINE-PROTEIN KINASE FRK
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	RCA	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00019	Endothelin signaling pathway	P00591	PLCbeta	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00021	FGF signaling pathway	P00638	PLCgamma	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00049	Parkinson disease	P01236	Casein kinase II	PANTR|Ensembl=ENSPTRG00000008175|UniProtKB=H2RA57	Uncharacterized protein	ISS	10617630	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00056	VEGF signaling pathway	P01407	Erk	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IGI	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00051	TCA cycle	P01266	Pyruvate Dehydrogenase	MONDO|Ensembl=ENSMODG00000012026|UniProtKB=F7AM02	Uncharacterized protein	ISS			PTHR11947:SF15	PYRUVATE DEHYDROGENASE  ACETYL-TRANSFERRING   KINASE ISOZYME 2, MITOCHONDRIAL
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	IGI	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01199	Galpha	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS			PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00470	F-actin	TAKRU|Ensembl=ENSTRUG00000004787|UniProtKB=P53480	Actin, alpha cardiac	IC	14684598	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05913	Enkephalin release	P05972	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00034	Integrin signalling pathway	P00922	Collagen	MOUSE|MGI=MGI=104688|UniProtKB=Q9QZS0	Collagen alpha-3(IV) chain	IDA	10778855	PubMed	PTHR24023:SF435	COLLAGEN ALPHA-3 IV  CHAIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	YEAST|SGD=S000001065|UniProtKB=P08964	Myosin-1	IC			PTHR13140:SF555	MYOSIN HEAVY CHAIN, MUSCLE
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05916	Opioid prodynorphin pathway	P06002	G-protein	MACMU|Ensembl=ENSMMUG00000014807|UniProtKB=F6W548	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00052	TGF-beta signaling pathway	P01284	JNK	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	TAS	10207617	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04393	Ras Pathway	P04578	Rho	HUMAN|HGNC=668|UniProtKB=P62745	Rho-related GTP-binding protein RhoB	ISS	11973360	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=620023|UniProtKB=P10980	Muscarinic acetylcholine receptor M2	IDA	8100450	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	BOVIN|Ensembl=ENSBTAG00000019210|UniProtKB=F1MJV4	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00019	Endothelin signaling pathway	P00591	PLCbeta	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05913	Enkephalin release	P05977	G-Protein (s)	CAEEL|WormBase=WBGene00001680|UniProtKB=Q20636	Guanine nucleotide-binding protein subunit beta-2	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00642	MEK1-2	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	IDA	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ORNAN|Ensembl=ENSOANG00000007405|UniProtKB=F7CIV4	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00046	Oxidative stress response	P01135	p38	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00254	GTPase	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	ISS	11360179	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00010	B cell activation	P00391	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00196	VRAP	MOUSE|MGI=MGI=1351596|UniProtKB=Q9QXK9	SH2 domain-containing protein 2A	IDA	604514	OMIM	PTHR14388:SF9	SH2 DOMAIN-CONTAINING PROTEIN 2A
P00018	EGF receptor signaling pathway	P00565	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	3755548	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	CANLF|Ensembl=ENSCAFG00000008720|UniProtKB=E2RQ42	Uncharacterized protein	ISS	2187864	PubMed	PTHR11800:SF2	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3
P00047	PDGF signaling pathway	P01154	Ras	ANOGA|EnsemblGenome=AGAP002219|UniProtKB=Q7QK91	AGAP002219-PA	ISS	10684567	PubMed	PTHR24070:SF385	GTPASE HRAS
P04393	Ras Pathway	P04558	p38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IDA	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MACMU|Ensembl=ENSMMUG00000001661|UniProtKB=F7GR69	Uncharacterized protein	ISS	11554554	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04547	Ras	XENTR|Xenbase=XB-GENE-6085898|UniProtKB=F6WDS0	Uncharacterized protein	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	NAS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00045	Notch signaling pathway	P01110	Presenilin	DANRE|ZFIN=ZDB-GENE-991119-4|UniProtKB=Q9W6T7	Presenilin-1	IGI	12101103	PubMed	PTHR10202:SF18	PRESENILIN-1
P00010	B cell activation	P00384	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IDA	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00916	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00852	PYK2	HUMAN|HGNC=9612|UniProtKB=Q14289	Protein-tyrosine kinase 2-beta	ISS	10753828	PubMed	PTHR24418:SF94	PROTEIN-TYROSINE KINASE 2-BETA
P04398	p53 pathway feedback loops 2	P04651	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	METAC|EnsemblGenome=MA_0278|UniProtKB=Q8TTZ7	TATA-box-binding protein 3	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00021	FGF signaling pathway	P00638	PLCgamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00047	PDGF signaling pathway	P01161	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00825	Thioredoxin	AQUAE|EnsemblGenome=aq_1916|UniProtKB=O67747	Thioredoxin	ISS			PTHR10438:SF215	THIOREDOXIN DOMAIN-CONTAINING PROTEIN, MITOCHONDRIAL
P00034	Integrin signalling pathway	P00927	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00012	Cadherin signaling pathway	P00475	Frizzled	HUMAN|HGNC=4042|UniProtKB=Q9ULV1	Frizzled-4	IDA	11212302	PubMed	PTHR11309:SF23	FRIZZLED-4
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00023	General transcription regulation	P00664	TFIIH complex	MOUSE|MGI=MGI=1277216|UniProtKB=Q9DBA9	General transcription factor IIH subunit 1	ISS			PTHR12856:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 1
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	MACMU|Ensembl=ENSMMUG00000014817|UniProtKB=F6VXD8	Uncharacterized protein	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	BATDJ|Gene=BATDEDRAFT_37213|UniProtKB=F4P7H8	Alpha-Beta tubulin	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	TAS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05913	Enkephalin release	P05974	G-Protein (i)	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	MACMU|Ensembl=ENSMMUG00000010173|UniProtKB=F7AGU8	Presenilin	ISS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CHICK|Ensembl=ENSGALG00000014975|UniProtKB=F1NTE9	Uncharacterized protein	IDA			PTHR43893:SF8	D 1B  DOPAMINE RECEPTOR
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	CANLF|Ensembl=ENSCAFG00000004098|UniProtKB=E2QTM5	Uncharacterized protein	ISS			PTHR24073:SF269	DNAJ HOMOLOG SUBFAMILY C MEMBER 27
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=94926|UniProtKB=P51436	D(4) dopamine receptor	IDA	1319557	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	MACMU|Ensembl=ENSMMUG00000015828|UniProtKB=F7CE90	Recombining binding protein suppressor of hairless isoform 4	ISS	8406481	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00005	Angiogenesis	P00203	Erk	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00646	RasGAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	IPI	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	RAT|RGD=61934|UniProtKB=Q63764	Antizyme inhibitor 1	ISS			PTHR11482:SF7	ANTIZYME INHIBITOR 1
P00009	Axon guidance mediated by netrin	P00364	cdc42	SCHPO|PomBase=SPAC110.03|UniProtKB=Q01112	Cell division control protein 42 homolog	ISS	4757952	gi	PTHR24072:SF192	CDC42 HOMOLOG
P00004	Alzheimer disease-presenilin pathway	P00118	E-cadherin	MOUSE|MGI=MGI=88356|UniProtKB=P10287	Cadherin-3	IDA	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P06664	Gonadotropin-releasing hormone receptor pathway	P06798	PKCe/theta	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04570	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05974	G-Protein (i)	ORNAN|Ensembl=ENSOANG00000003489|UniProtKB=F7FSE3	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P02772	Pyruvate metabolism	P03140	Pyruvate Carboxylase	EMENI|EnsemblGenome=CADANIAG00005990|UniProtKB=Q5B4R8	Pyruvate carboxylase	ISS	3806120	gi	PTHR43778:SF2	PYRUVATE CARBOXYLASE, MITOCHONDRIAL
P00011	Blood coagulation	P00458	GP IIIa	CHICK|Ensembl=ENSGALG00000000379|UniProtKB=Q92071	Integrin beta	ISS	3487386	PubMed	PTHR10082:SF25	INTEGRIN BETA-3
P02779	Thiamin biosynthesis	P03170	Hydroxymethylpyrimidine phosphate kinase	YEAST|SGD=S000006179|UniProtKB=Q08975	Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21	ISS			PTHR20858:SF17	HYDROXYMETHYLPYRIMIDINE/PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	CANLF|Ensembl=ENSCAFG00000001437|UniProtKB=E2RPD9	Uncharacterized protein	ISS	415387	gi	PTHR10773:SF12	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2
P00034	Integrin signalling pathway	P00923	Arf1	DANRE|ZFIN=ZDB-GENE-030131-5234|UniProtKB=Q7ZUZ7	ADP-ribosylation factor 1	ISS	12932731	PubMed	PTHR11711:SF291	ADP-RIBOSYLATION FACTOR 1
P02786	Vitamin B6 biosynthesis	P03225	1-Deoxyxylulose-5-phosphate synthase	MYCTU|EnsemblGenome=LH57_18455|UniProtKB=O50408	1-deoxy-D-xylulose-5-phosphate synthase	ISS			PTHR43322:SF6	1-DEOXY-D-XYLULOSE-5-PHOSPHATE SYNTHASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	ANOGA|Gene=AgaP_AGAP009278|UniProtKB=Q7PVH2	AGAP009278-PA	IDA	10487978	PubMed	PTHR10749:SF8	PHOSPHORYLASE B KINASE REGULATORY SUBUNIT BETA
P00021	FGF signaling pathway	P00645	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	MONDO|Ensembl=ENSMODG00000006553|UniProtKB=F7BUW7	Uncharacterized protein	ISS	11212302	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00775	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01199	Galpha	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IC	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04398	p53 pathway feedback loops 2	G04714	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	CANLF|Ensembl=ENSCAFG00000005449|UniProtKB=F1PNA9	TGF-beta receptor type-2	ISS	9395284	PubMed	PTHR23255:SF55	TGF-BETA RECEPTOR TYPE-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	XENTR|Xenbase=XB-GENE-984047|UniProtKB=F7E152	Uncharacterized protein (Fragment)	ISS	9388255	PubMed	PTHR10292:SF7	CLATHRIN HEAVY CHAIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DICPU|Gene=DICPUDRAFT_93216|UniProtKB=F1A421	Guanine nucleotide-binding protein subunit beta	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PRIPA|Gene=PPA02894|UniProtKB=H3DZP3	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF120	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00801	Fos protein	RAT|RGD=2626|UniProtKB=P12841	Proto-oncogene c-Fos	TAS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04395	Vasopressin synthesis	P04590	Vasopressin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00053	T cell activation	P01322	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00057	Wnt signaling pathway	P01433	SIAH-1	CAEEL|WormBase=WBGene00021369|UniProtKB=Q965X6	E3 ubiquitin-protein ligase siah-1	ISS	11389839	PubMed	PTHR10315:SF70	E3 UBIQUITIN-PROTEIN LIGASE SINA-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00786	ARF	XENTR|Xenbase=XB-GENE-967358|UniProtKB=F6V4X2	Uncharacterized protein (Fragment)	ISS	12932731	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	CAEEL|WormBase=WBGene00000065|UniProtKB=P0DM42	Actin-3	IC	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	MOUSE|MGI=MGI=96539|UniProtKB=P43431	Interleukin-12 subunit alpha	TAS	12189243	PubMed	PTHR45311:SF1	INTERLEUKIN-12 SUBUNIT ALPHA
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00648	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01160	IP3 receptor	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00006	Apoptosis signaling pathway	P00269	MAPK	ORYSJ|EnsemblGenome=OS06G0699400|UniProtKB=Q5Z859	Mitogen-activated protein kinase 4	ISS	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02748	Isoleucine biosynthesis	P02997	Acetolactate synthase	PSEAE|EnsemblGenome=PA4180|UniProtKB=Q9HWK1	Probable acetolactate synthase large subunit	ISS			PTHR18968:SF129	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	HUMAN|HGNC=18123|UniProtKB=Q8NER5	Activin receptor type-1C	TAS	9395284	PubMed	PTHR23255:SF58	ACTIVIN RECEPTOR TYPE-1C
P02741	Flavin biosynthesis	P02934	Riboflavin kinase	MOUSE|MGI=MGI=1914688|UniProtKB=Q8CFV9	Riboflavin kinase	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P00018	EGF receptor signaling pathway	P00556	PLCgamma	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	YEAST|SGD=S000005738|UniProtKB=P18851	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06587	Nicotine pharmacodynamics pathway	P06602	PPP1CA	DAPPU|EnsemblGenome=DAPPUDRAFT_194510|UniProtKB=E9G7U7	Serine/threonine-protein phosphatase (Fragment)	ISS	8392016	PubMed	PTHR11668:SF282	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-BETA CATALYTIC SUBUNIT
P06587	Nicotine pharmacodynamics pathway	P06606	ADCY2	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00029	Huntington disease	P00774	Dynein complex	MACMU|Ensembl=ENSMMUG00000011026|UniProtKB=F7GQS3	Uncharacterized protein	ISS	9454836	PubMed	PTHR10676:SF240	DYNEIN HEAVY CHAIN 5, AXONEMAL
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00170	Aph-1	PANTR|Ensembl=ENSPTRG00000007146|UniProtKB=H2Q9J9	Anterior pharynx defective 1 homolog B	ISS	12110170	PubMed	PTHR12889:SF1	GAMMA-SECRETASE SUBUNIT APH-1B
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MOUSE|MGI=MGI=96276|UniProtKB=Q61224	5-hydroxytryptamine receptor 1D	ISS	12181435	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00010	B cell activation	P00383	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	IDA	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00001	Adrenaline and noradrenaline biosynthesis	P00071	VAT1	HUMAN|HGNC=10934|UniProtKB=P54219	Chromaffin granule amine transporter	ISS	11443533	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00006	Apoptosis signaling pathway	P00310	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	TAS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05731	GABA-B receptor II signaling	P05754	Ggamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00029	Huntington disease	P00805	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	CHICK|Ensembl=ENSGALG00000009320|UniProtKB=Q4JIM4	Presenilin-1	IDA	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	IGI	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	RCA	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00057	Wnt signaling pathway	P01451	Galpha	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	BOVIN|Ensembl=ENSBTAG00000004242|UniProtKB=Q1JP79	Actin-related protein 2/3 complex subunit 1A	ISS	12932731	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01026	KA	CANLF|Ensembl=ENSCAFG00000004930|UniProtKB=E2RFB5	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00021	FGF signaling pathway	P00629	PP2A	BOVIN|Ensembl=ENSBTAG00000001862|UniProtKB=Q5E9Q7	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform	ISS	12716901	PubMed	PTHR11871:SF1	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B BETA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=12774|UniProtKB=P04628	Proto-oncogene Wnt-1	IDA	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00015	Circadian clock system	P00502	Casein kinase I	MOUSE|MGI=MGI=1355272|UniProtKB=Q9DC28	Casein kinase I isoform delta	ISS	10617630	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P05918	p38 MAPK pathway	P06024	eIF4E	XENTR|Xenbase=XB-GENE-855435|UniProtKB=F6ZT05	Uncharacterized protein	ISS			PTHR11960:SF14	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E
P00057	Wnt signaling pathway	P01457	GBeta	SCLS1|EnsemblGenome=SS1G_03482|UniProtKB=A7EDU2	Guanine nucleotide-binding protein beta subunit	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PHANO|EnsemblGenome=SNOG_01139|UniProtKB=H2KNE6	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00019	Endothelin signaling pathway	P00572	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	YEAST|SGD=S000001295|UniProtKB=P07278	cAMP-dependent protein kinase regulatory subunit	ISS	91298951	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00059	p53 pathway	P04612	HDAC1	USTMA|Gene=UMAG_02065|UniProtKB=A0A0D1E0Y7	Chromosome 5, whole genome shotgun sequence	ISS	10485845	PubMed	PTHR10625:SF141	HISTONE DEACETYLASE RPD3
P00019	Endothelin signaling pathway	P00566	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00049	Parkinson disease	P01236	Casein kinase II	BOVIN|Ensembl=ENSBTAG00000008837|UniProtKB=P67868	Casein kinase II subunit beta	IDA	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01458	Protein Kinase C	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	MOUSE|MGI=MGI=2151136|UniProtKB=Q9JI18	Low-density lipoprotein receptor-related protein 1B	IDA	11907044	PubMed	PTHR44025:SF7	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B
P00035	Interferon-gamma signaling pathway	P00958	PIAS	BOVIN|Ensembl=ENSBTAG00000000753|UniProtKB=A4FV15	PIAS4 protein	ISS	8682149	PubMed	PTHR10782:SF9	E3 SUMO-PROTEIN LIGASE PIAS4
P00023	General transcription regulation	P00668	TFIIB	ANOGA|EnsemblGenome=AGAP004233|UniProtKB=Q7QB20	AGAP004233-PA	ISS	180660	OMIM	PTHR11618:SF4	TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT
P00034	Integrin signalling pathway	P00916	Ras	DANRE|ZFIN=ZDB-GENE-990415-166|UniProtKB=P79737	GTPase NRas	IPI	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	ANOGA|EnsemblGenome=AGAP002219|UniProtKB=Q7QK91	AGAP002219-PA	ISS	10684567	PubMed	PTHR24070:SF385	GTPASE HRAS
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00036	Interleukin signaling pathway	P00981	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	IC	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00036	Interleukin signaling pathway	P00987	SRF	MONDO|Ensembl=ENSMODG00000018981|UniProtKB=F7FP88	Uncharacterized protein	ISS	15170389	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	ANOGA|EnsemblGenome=AGAP001506|UniProtKB=Q7PXP3	AGAP001506-PA	IC			PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00021	FGF signaling pathway	P00632	Akt	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	IGI	98382502	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00029	Huntington disease	G01535	PIG3	CHICK|Ensembl=ENSGALG00000013225|UniProtKB=E1BZH3	Uncharacterized protein	ISS	12932731	PubMed	PTHR44054:SF2	SYNAPTIC VESICLE MEMBRANE PROTEIN VAT-1 HOMOLOG-LIKE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MONDO|Ensembl=ENSMODG00000020204|UniProtKB=F6SED9	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	IC	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00051	TCA cycle	P01274	Succinyl CoA Synthetase	CANLF|Ensembl=ENSCAFG00000007987|UniProtKB=E2R0Y5	Uncharacterized protein	ISS	97407896	PubMed	PTHR11117:SF2	SUCCINYL-COA LIGASE  ADP/GDP-FORMING  SUBUNIT ALPHA, MITOCHONDRIAL
P04393	Ras Pathway	P04557	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	IDA	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00006	Apoptosis signaling pathway	P00318	PKCs	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00053	T cell activation	P01322	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00063	DBH	MOUSE|MGI=MGI=94864|UniProtKB=Q64237	Dopamine beta-hydroxylase	ISS	90219125	PubMed	PTHR10157:SF29	DOPAMINE BETA-HYDROXYLASE
P00006	Apoptosis signaling pathway	P00260	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00363	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	RAT|RGD=71027|UniProtKB=P42264	Glutamate receptor ionotropic, kainate 3	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	LEIMA|EnsemblGenome=LmjF.18.1080|UniProtKB=Q27687	Protein kinase A catalytic subunit	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	MOUSE|MGI=MGI=103034|UniProtKB=P52633	Signal transducer and transcription activator 6	TAS	14598258	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00047	PDGF signaling pathway	P01168	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	96009592	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00018	EGF receptor signaling pathway	P00565	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00047	PDGF signaling pathway	P01150	PKC	YEAST|SGD=S000000201|UniProtKB=P24583	Protein kinase C-like 1	ISS	90322419	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00047	PDGF signaling pathway	P01159	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00059	p53 pathway	P04633	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04393	Ras Pathway	P04553	PAK	HUMAN|HGNC=8590|UniProtKB=Q13153	Serine/threonine-protein kinase PAK 1	IDA	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00034	Integrin signalling pathway	P00907	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	9603989	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01167	Ets	HUMAN|HGNC=3488|UniProtKB=P14921	Protein C-ets-1	ISS	9157999	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IC	10395542	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00056	VEGF signaling pathway	P01409	cPLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00048	PI3 kinase pathway	P01192	p110	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT1G10210|UniProtKB=Q39021	Mitogen-activated protein kinase 1	IDA	10851062	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00046	Oxidative stress response	P01135	p38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	TAS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	PANTR|Ensembl=ENSPTRG00000007084|UniProtKB=H2Q9G5	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IDA	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	XENTR|Xenbase=XB-GENE-484322|UniProtKB=F6RPG1	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF22	FRIZZLED-3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	RCA	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	IDA	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00053	T cell activation	P01300	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00203	Erk	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00182	p38MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04395	Vasopressin synthesis	P04597	Signal Peptide	BOVIN|Ensembl=ENSBTAG00000008026|UniProtKB=P01175	Oxytocin-neurophysin 1	ISS	9756087	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00034	Integrin signalling pathway	P00944	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g234494|UniProtKB=A7RU31	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00034	Integrin signalling pathway	P00925	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00010	B cell activation	P00398	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IGI	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	HUMAN|HGNC=9508|UniProtKB=P49768	Presenilin-1	TAS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	TAS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00045	Notch signaling pathway	P01113	Pen-2	RAT|RGD=621060|UniProtKB=O88777	Presenilin-2	IEP	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	CAEEL|WormBase=WBGene00010038|UniProtKB=P34443	GTP-binding protein Rheb homolog 1	ISS			PTHR24070:SF226	GTP-BINDING PROTEIN RHEB HOMOLOG
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	TAS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04570	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04398	p53 pathway feedback loops 2	P04665	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00005	Angiogenesis	P00249	PAK	BOVIN|Ensembl=ENSBTAG00000047856|UniProtKB=G3MZE2	Uncharacterized protein	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00260	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00470	F-actin	EMENI|EnsemblGenome=CADANIAG00007315|UniProtKB=P20359	Actin, gamma	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00048	PI3 kinase pathway	P01196	PDK1	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	9094314	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00036	Interleukin signaling pathway	P00966	mTOR	PANTR|Ensembl=ENSPTRG00000000142|UniProtKB=H2PY03	Uncharacterized protein	ISS	7518356	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00025	Hedgehog signaling pathway	P00692	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	IC	176892	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04494	TSC2	PANTR|Ensembl=ENSPTRG00000031311|UniProtKB=H2R1U8	Uncharacterized protein	ISS	12150915	PubMed	PTHR10063:SF0	TUBERIN
P00036	Interleukin signaling pathway	P00983	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00010	B cell activation	P00381	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	IGI	12411479	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00034	Integrin signalling pathway	P00950	Paxillin	PANTR|Ensembl=ENSPTRG00000005527|UniProtKB=H2Q704	Paxillin	ISS	7579684	PubMed	PTHR24216:SF11	PAXILLIN
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MACMU|Ensembl=ENSMMUG00000010392|UniProtKB=F7ASR8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	PANTR|Ensembl=ENSPTRG00000014843|UniProtKB=Q9TV16	C-X-C chemokine receptor type 6	ISS	11238560	PubMed	PTHR10489:SF705	C-X-C CHEMOKINE RECEPTOR TYPE 6
P00060	Ubiquitin proteasome pathway	P01492	E1	HUMAN|HGNC=12470|UniProtKB=Q8TBC4	NEDD8-activating enzyme E1 catalytic subunit	ISS			PTHR10953:SF6	NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT
P00057	Wnt signaling pathway	P01446	Calcineurin	MONDO|Ensembl=ENSMODG00000003614|UniProtKB=F7C6H2	Uncharacterized protein (Fragment)	ISS	12015605	PubMed	PTHR23056:SF4	PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_58093|UniProtKB=C3Z4K3	Putative uncharacterized protein	IDA	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DANRE|ZFIN=ZDB-GENE-041210-195|UniProtKB=F1R506	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00127	APP	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	MOUSE|MGI=MGI=99684|UniProtKB=A2AGL3	Ryanodine receptor 3	ISS	15226293	PubMed	PTHR13715:SF16	RYANODINE RECEPTOR 3
P00005	Angiogenesis	P00231	HSP27	HUMAN|HGNC=2388|UniProtKB=P02489	Alpha-crystallin A chain	IDA			PTHR11527:SF36	ALPHA-CRYSTALLIN A CHAIN
P05730	Endogenous cannabinoid signaling	P05746	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00994	FKHRL1	MOUSE|MGI=MGI=1890081|UniProtKB=Q9WVH4	Forkhead box protein O3	IPI	15031210	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00009	Axon guidance mediated by netrin	P00366	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01306	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05730	Endogenous cannabinoid signaling	P05751	Galpha	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	RCA	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00010	B cell activation	P00385	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12912997	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	XENTR|Xenbase=XB-GENE-969601|UniProtKB=Q28H40	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00048	PI3 kinase pathway	P01192	p110	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00018	EGF receptor signaling pathway	P00556	PLCgamma	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04393	Ras Pathway	P04570	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00019	Endothelin signaling pathway	P00586	Gq	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00057	Wnt signaling pathway	P01457	GBeta	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CAEEL|WormBase=WBGene00003774|UniProtKB=G5EGQ9	NMDA class glutamate Receptor	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00034	Integrin signalling pathway	P00936	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IPI	12660731	PubMed	PTHR10048:SF14	PI-3 KINASE
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	CAEEL|WormBase=WBGene00000107|UniProtKB=Q20780	ALdehyde deHydrogenase	IC			PTHR11699:SF265	ALDEHYDE DEHYDROGENASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT4G36450|UniProtKB=O23236	Mitogen-activated protein kinase 14	ISS	12787066	PubMed	PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P00010	B cell activation	P00381	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01161	Raf	DANRE|ZFIN=ZDB-GENE-040805-1|UniProtKB=Q1LYG2	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00057	Wnt signaling pathway	P01428	Frizzled	MACMU|Ensembl=ENSMMUG00000004048|UniProtKB=F6ZR92	Frizzled-4	ISS	11212302	PubMed	PTHR11309:SF23	FRIZZLED-4
P00034	Integrin signalling pathway	P00920	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	HUMAN|HGNC=2514|UniProtKB=P35222	Catenin beta-1	IDA	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00010	B cell activation	P00376	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00069	COMT	MACMU|Ensembl=ENSMMUG00000017152|UniProtKB=F6QFW9	Catechol O-methyltransferase isoform MB-COMT	ISS	12842307	PubMed	PTHR43836:SF3	CATECHOL O-METHYLTRANSFERASE
P00005	Angiogenesis	P00181	SHP2	CANLF|Ensembl=ENSCAFG00000008894|UniProtKB=F1Q3J6	Tyrosine-protein phosphatase non-receptor type	ISS	1382983	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00778	NMDA receptor	CANLF|Ensembl=ENSCAFG00000002617|UniProtKB=E2QUL1	Uncharacterized protein	ISS	11554549	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00021	FGF signaling pathway	P00633	Ras	DANRE|ZFIN=ZDB-GENE-040808-67|UniProtKB=Q6AZA4	K-ras	ISS	10825661	PubMed	PTHR24070:SF186	GTPASE KRAS
P02738	De novo purine biosynthesis	P02909	GDP reductase	MYCTU|EnsemblGenome=Rv3048c|UniProtKB=P9WH71	Ribonucleoside-diphosphate reductase subunit beta nrdF2	ISS			PTHR23409:SF32	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00052	TGF-beta signaling pathway	P01275	P38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	TAS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00012	Cadherin signaling pathway	P00474	Wnt	BOVIN|Ensembl=ENSBTAG00000015364|UniProtKB=E1BEN9	Protein Wnt	ISS	14644163	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00022	General transcription by RNA polymerase I	P00657	TBP	XENTR|Xenbase=XB-GENE-488460|UniProtKB=Q6DIY4	TATA box-binding protein-like protein 1	ISS	10470030	PubMed	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00018	EGF receptor signaling pathway	P00545	JNK1-3	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IGI	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00006	Apoptosis signaling pathway	P00317	Fos	PANTR|Ensembl=ENSPTRG00000006553|UniProtKB=A5A6H0	C-fos	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P02723	Adenine and hypoxanthine salvage pathway	P02812	Deoxyinosine phosphorylase	CAEEL|WormBase=WBGene00019298|UniProtKB=U4PSA1	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00029	Huntington disease	P00801	Fos protein	RAT|RGD=2626|UniProtKB=P12841	Proto-oncogene c-Fos	TAS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	YEAST|SGD=S000004795|UniProtKB=P39926	Protein SSO2	IC			PTHR19957:SF41	SYNTAXIN-1A
P00029	Huntington disease	P00807	Actin	GIAIC|EnsemblGenome=GL50803_40817|UniProtKB=A8BV70	Actin related protein	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04393	Ras Pathway	P04570	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02785	Valine biosynthesis	P03215	Branched chain amino acid aminotransferase	HUMAN|HGNC=976|UniProtKB=P54687	Branched-chain-amino-acid aminotransferase, cytosolic	ISS			PTHR11825:SF51	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, CYTOSOLIC
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	SCHPO|PomBase=SPBC14C8.12|UniProtKB=Q92399	DNA-directed RNA polymerases I, II, and III subunit RPABC3	ISS	606023	OMIM	PTHR10917:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3
P00057	Wnt signaling pathway	P01447	Dishevelled	MONDO|Ensembl=ENSMODG00000003229|UniProtKB=F6TYA8	Uncharacterized protein (Fragment)	ISS	10409711	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P04393	Ras Pathway	P04557	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IDA	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MACMU|Ensembl=ENSMMUG00000004994|UniProtKB=F7ATP9	Syntaxin-7	ISS	14570579	PubMed	PTHR19957:SF90	SYNTAXIN-7
P00049	Parkinson disease	P01211	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P06959	CCKR signaling map	P07151	p52 SHC1	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	RCA	9230117	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	BOVIN|Ensembl=ENSBTAG00000002081|UniProtKB=A7YWG6	Serine/threonine-protein kinase receptor	ISS	9395284	PubMed	PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P00036	Interleukin signaling pathway	P00990	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IC	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00052	TGF-beta signaling pathway	P01286	TGFbeta	PANTR|Ensembl=ENSPTRG00000002043|UniProtKB=H2Q183	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF232	LEFT-RIGHT DETERMINATION FACTOR 2
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00056	VEGF signaling pathway	P01417	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00018	EGF receptor signaling pathway	P00557	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	ISS	11956331	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02731	Biotin biosynthesis	P02858	8-Amino-7-oxononanoate synthase	LEPIN|EnsemblGenome=LA_2140|UniProtKB=Q8F4A1	8-amino-7-oxononanoate synthase	ISS			PTHR13693:SF77	8-AMINO-7-OXONONANOATE SYNTHASE
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000010830|UniProtKB=E1BGJ0	Uncharacterized protein	ISS	11907044	PubMed	PTHR44025:SF2	PROLOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1
P00047	PDGF signaling pathway	P01142	p90RSK	MONDO|Ensembl=ENSMODG00000014313|UniProtKB=F7BTW0	Ribosomal protein S6 kinase	ISS	15116068	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01153	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	IC	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05731	GABA-B receptor II signaling	P05754	Ggamma	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00018	EGF receptor signaling pathway	P00562	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	MONDO|Ensembl=ENSMODG00000017905|UniProtKB=F7FG65	Tyrosine-protein kinase	ISS	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00006	Apoptosis signaling pathway	P00313	IKK	CANLF|Ensembl=ENSCAFG00000005526|UniProtKB=E2RKR0	Uncharacterized protein	ISS	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00006	Apoptosis signaling pathway	P00268	GCK	MOUSE|MGI=MGI=1925503|UniProtKB=Q8BPM2	Mitogen-activated protein kinase kinase kinase kinase 5	ISS			PTHR24361:SF324	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 5
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	TAKRU|Ensembl=ENSTRUG00000011944|UniProtKB=H2TZX5	Uncharacterized protein	ISS	10556059	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P06664	Gonadotropin-releasing hormone receptor pathway	P06761	Adiponectin	MOUSE|MGI=MGI=106675|UniProtKB=Q60994	Adiponectin	RCA			PTHR44524:SF2	ADIPONECTIN
P04397	p53 pathway by glucose deprivation	P04636	S6K	HUMAN|HGNC=10436|UniProtKB=P23443	Ribosomal protein S6 kinase beta-1	IDA	11861821	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	XENTR|Xenbase=XB-GENE-487022|UniProtKB=F6SH04	Uncharacterized protein (Fragment)	ISS	11212302	PubMed	PTHR11309:SF34	FRIZZLED-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00950	Paxillin	DICDI|dictyBase=DDB_G0274109|UniProtKB=Q8MML5	Paxillin-B	IPI	7579684	PubMed	PTHR24216:SF47	PAXILLIN-B
P00060	Ubiquitin proteasome pathway	P01491	E2	PANTR|Ensembl=ENSPTRG00000003661|UniProtKB=H2Q3P2	Ubiquitin-conjugating enzyme E2L 6	ISS	11078524	PubMed	PTHR24068:SF43	UBIQUITIN/ISG15-CONJUGATING ENZYME E2 L6
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	XENTR|Xenbase=XB-GENE-490534|UniProtKB=F7CQJ3	Uncharacterized protein (Fragment)	ISS	9230079	PubMed	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00029	Huntington disease	P00805	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	IGI	12787066	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P04393	Ras Pathway	P04558	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CHLRE|EnsemblGenome=CHLREDRAFT_24392|UniProtKB=A8JAV1	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00045	Notch signaling pathway	P01103	Next	HUMAN|HGNC=6189|UniProtKB=Q9Y219	Protein jagged-2	IC			PTHR44097:SF1	PROTEIN JAGGED-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	XENTR|Xenbase=XB-GENE-482586|UniProtKB=F6QUB0	Uncharacterized protein	ISS	4504609	gi	PTHR11454:SF10	INSULIN-LIKE GROWTH FACTOR II
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00702	CPB	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	RCA			PTHR13808:SF5	CREB-BINDING PROTEIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	RCA	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00052	TGF-beta signaling pathway	P01275	P38	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	TAS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00049	Parkinson disease	P01211	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00547	PP2A	MOUSE|MGI=MGI=1321159|UniProtKB=P63330	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00642	MEK1-2	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IGI	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00036	Interleukin signaling pathway	P00964	p90RSK	HUMAN|HGNC=10432|UniProtKB=P51812	Ribosomal protein S6 kinase alpha-3	ISS	2779569	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P05915	Opioid proenkephalin pathway	P05987	peptide F	HUMAN|HGNC=8831|UniProtKB=P01210	Proenkephalin-A	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PHYPA|Gene=PHYPADRAFT_232451|UniProtKB=A9SKU2	Predicted protein	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00005	Angiogenesis	P00234	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	8479536	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	ISS	11554549	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	XENTR|Xenbase=XB-GENE-1013749|UniProtKB=A0JP99	LOC100036644 protein	ISS			PTHR24361:SF345	SERINE/THREONINE-PROTEIN KINASE PAK 4
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00029	Huntington disease	P00764	MLK-2	HUMAN|HGNC=6849|UniProtKB=Q02779	Mitogen-activated protein kinase kinase kinase 10	RCA			PTHR43997:SF5	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 10
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	MOUSE|MGI=MGI=1351342|UniProtKB=Q3UVX5	Metabotropic glutamate receptor 5	ISS	8314195	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	MOUSE|MGI=MGI=1352450|UniProtKB=P17515	C-X-C motif chemokine 10	IDA	12021306	PubMed	PTHR10179:SF47	C-X-C MOTIF CHEMOKINE 10
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PUCGT|EnsemblGenome=PGTG_05488|UniProtKB=E3K4I1	Actin	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05731	GABA-B receptor II signaling	P05760	AC	MOUSE|MGI=MGI=99677|UniProtKB=O88444	Adenylate cyclase type 1	ISS	89298382	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	MYCTU|EnsemblGenome=Rv2222c|UniProtKB=P9WN37	Probable glutamine synthetase 2	ISS			PTHR43785:SF1	TYPE-1 GLUTAMINE SYNTHETASE 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00057	Wnt signaling pathway	P01451	Galpha	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00030	Hypoxia response via HIF activation	P00817	TOR	SCHPO|PomBase=SPBC30D10.10c|UniProtKB=O14356	Serine/threonine-protein kinase tor1	ISS			PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00005	Angiogenesis	P00223	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02770	Pyridoxal phosphate salvage pathway	P03120	Pyridoxamine-5-phosphate oxidase	ECOLI|EcoGene=EG11487|UniProtKB=P0AFI7	Pyridoxine/pyridoxamine 5'-phosphate oxidase	ISS	11786019	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00060	Ubiquitin proteasome pathway	P01491	E2	ORNAN|Ensembl=ENSOANG00000009823|UniProtKB=F6RWK8	Uncharacterized protein	ISS			PTHR43898:SF4	UBIQUITIN-CONJUGATING ENZYME E2 A
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	G01540	BDNF	ORNAN|Ensembl=ENSOANG00000013030|UniProtKB=O02795	Brain-derived neurotrophic factor (Fragment)	ISS	12117585	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	RAT|RGD=2739|UniProtKB=Q00961	Glutamate receptor ionotropic, NMDA 2C	IC	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	DEIRA|EnsemblGenome=DR_1573|UniProtKB=Q9RU23	CTP synthase	ISS			PTHR11550:SF0	CTP SYNTHASE
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00359	NFAT	PANTR|Ensembl=ENSPTRG00000008260|UniProtKB=H2QBD7	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	ISS	9462517	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P04393	Ras Pathway	P04546	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00048	PI3 kinase pathway	P01177	P110ACT	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	ECOLI|EcoGene=EG13908|UniProtKB=P78061	Gamma-glutamylputrescine synthetase PuuA	ISS			PTHR43785:SF1	TYPE-1 GLUTAMINE SYNTHETASE 2
P00059	p53 pathway	P04630	PP2A	TAKRU|Ensembl=ENSTRUG00000008018|UniProtKB=H2T5N4	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00224	PDGF	MACMU|Ensembl=ENSMMUG00000022900|UniProtKB=F6WES5	Uncharacterized protein	ISS			PTHR11633:SF5	PLATELET-DERIVED GROWTH FACTOR C
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	ORNAN|Ensembl=ENSOANG00000000818|UniProtKB=F6PLI7	Uncharacterized protein	ISS			PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	TAS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00011	Blood coagulation	P00412	PS	MOUSE|MGI=MGI=1095733|UniProtKB=Q08761	Vitamin K-dependent protein S	ISS			PTHR24040:SF0	VITAMIN K-DEPENDENT PROTEIN S
P00006	Apoptosis signaling pathway	P00321	HSP70	DICDI|dictyBase=DDB_G0269144|UniProtKB=P36415	Heat shock cognate 70 kDa protein 1	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	DAPPU|EnsemblGenome=DAPPUDRAFT_206575|UniProtKB=E9FUX0	Guanine nucleotide binding protein, beta subunit	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04397	p53 pathway by glucose deprivation	P04641	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04384	Gamma-aminobutyric acid synthesis	P04480	GABA aminotransferase	DROME|FlyBase=FBgn0036927|UniProtKB=Q9VW68	CG7433, isoform A	ISS	8133261	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00049	Parkinson disease	P01211	ERK	CAEEL|WormBase=WBGene00015478|UniProtKB=Q11179	Putative serine/threonine-protein kinase C05D10.2	IDA	10851062	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00019	Endothelin signaling pathway	P00575	furin	BOVIN|Gene=FURIN|UniProtKB=Q28193	Furin	ISS	10956649	PubMed	PTHR42884:SF1	FURIN
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	ARATH|TAIR=AT5G15570|UniProtKB=Q9LF25	Bromodomain transcription factor	ISS	604903	OMIM	PTHR12321:SF53	BROMODOMAIN TRANSCRIPTION FACTOR
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	XENTR|GeneID=394982|UniProtKB=P20399	Actin, alpha cardiac muscle 2	ISS	10974003	PubMed	PTHR11937:SF263	ACTIN
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	BOVIN|Ensembl=ENSBTAG00000004322|UniProtKB=O77628	Proto-oncogene c-Fos	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P02744	Fructose galactose metabolism	P02964	Hexose 1-P uridyltransferase	MOUSE|MGI=MGI=95638|UniProtKB=Q03249	Galactose-1-phosphate uridylyltransferase	ISS	1427861	PubMed	PTHR11943:SF1	GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE
P04393	Ras Pathway	P04578	Rho	BOVIN|Ensembl=ENSBTAG00000046054|UniProtKB=Q3ZBW5	Rho-related GTP-binding protein RhoB	ISS	11973360	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	CAEEL|WormBase=WBGene00001679|UniProtKB=P17343	Guanine nucleotide-binding protein subunit beta-1	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	MOUSE|MGI=MGI=1930182|UniProtKB=Q9WV85	Nucleoside diphosphate kinase 3	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	ANOGA|EnsemblGenome=AGAP001478|UniProtKB=Q7PXM3	AGAP001478-PA	IC	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00029	Huntington disease	P00775	Rac	IXOSC|EnsemblGenome=ISCW003614|UniProtKB=B7PHY7	Cdc42 protein, putative	ISS			PTHR24072:SF192	CDC42 HOMOLOG
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	PANTR|Ensembl=ENSPTRG00000015034|UniProtKB=H2QMT4	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P05913	Enkephalin release	P05976	Enkephalin	MOUSE|MGI=MGI=104629|UniProtKB=P22005	Proenkephalin-A	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	LEIMA|EnsemblGenome=LmjF.18.1080|UniProtKB=Q27687	Protein kinase A catalytic subunit	IC	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00059	p53 pathway	P04612	HDAC1	MONDO|Ensembl=ENSMODG00000017455|UniProtKB=F6Z5R3	Uncharacterized protein (Fragment)	ISS	10485845	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	PANTR|Ensembl=ENSPTRG00000018684|UniProtKB=C7G3M7	Glutamate receptor, metabotropic 1	ISS	12488551	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00035	Interferon-gamma signaling pathway	P00956	SOCS	MACMU|Ensembl=ENSMMUG00000010497|UniProtKB=F7BFK3	Cytokine-inducible SH2-containing protein isoform 2	ISS	15032587	PubMed	PTHR44649:SF1	CYTOKINE-INDUCIBLE SH2-CONTAINING PROTEIN
P00059	p53 pathway	P04630	PP2A	MACMU|Ensembl=ENSMMUG00000020819|UniProtKB=F7HSM1	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00941	Integrin alpha	DROME|FlyBase=FBgn0034005|UniProtKB=Q9V7A4	Integrin alpha-PS4	IPI	3487386	PubMed	PTHR23220:SF83	INTEGRIN ALPHA-PS3-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	TAKRU|Ensembl=ENSTRUG00000007989|UniProtKB=P68140	Actin, alpha skeletal muscle A	ISS	14684598	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00018	EGF receptor signaling pathway	P00549	EGF	RAT|RGD=620275|UniProtKB=Q9JJM4	Betacellulin	ISS			PTHR10740:SF3	PROBETACELLULIN
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00021	FGF signaling pathway	P00648	PKC	CANAL|CGD=CAL0003231|UniProtKB=Q5ANK2	Protein kinase C	IGI	96408767	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	11832947	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	TAS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00029	Huntington disease	P00810	GAPDH	PHYPA|Gene=PHYPADRAFT_226280|UniProtKB=P34923	Glyceraldehyde-3-phosphate dehydrogenase, cytosolic	IPI			PTHR10836:SF76	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE A
P00016	Cytoskeletal regulation by Rho GTPase	P00516	Ena/VASP	MOUSE|MGI=MGI=108360|UniProtKB=Q03173	Protein enabled homolog	ISS			PTHR11202:SF1	PROTEIN ENABLED HOMOLOG
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MACMU|Ensembl=ENSMMUG00000009771|UniProtKB=F6ZHU6	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF681	MYOSIN-4
P00009	Axon guidance mediated by netrin	P00359	NFAT	BOVIN|Ensembl=ENSBTAG00000004368|UniProtKB=F1MSU2	Uncharacterized protein	ISS	12787506	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00060	Ubiquitin proteasome pathway	P01491	E2	MONDO|Ensembl=ENSMODG00000010301|UniProtKB=F6SSD2	Uncharacterized protein	ISS			PTHR24068:SF63	UBIQUITIN-CONJUGATING ENZYME E2 E3
P00047	PDGF signaling pathway	P01150	PKC	PANTR|Ensembl=ENSPTRG00000000931|UniProtKB=H2PZC4	Protein kinase N2	ISS	11554554	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00006	Apoptosis signaling pathway	P00276	TRAIL-R	HUMAN|HGNC=11904|UniProtKB=O00220	Tumor necrosis factor receptor superfamily member 10A	IDA	11498783	PubMed	PTHR23097:SF179	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10A
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	RAT|RGD=2323655|UniProtKB=D4A7M6	Protein LOC100359539	ISS			PTHR23409:SF20	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	IC	176910	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	RAT|RGD=2347|UniProtKB=P20420	Neuronal acetylcholine receptor subunit alpha-5	IC	12388584	PubMed	PTHR18945:SF76	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00010	B cell activation	P00383	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02747	Histidine biosynthesis	P02988	Histidinal dehydrogenase	AQUAE|EnsemblGenome=aq_782|UniProtKB=O66976	Histidinol dehydrogenase	ISS			PTHR21256:SF2	HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00034	Integrin signalling pathway	P00911	B-Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00034	Integrin signalling pathway	P00948	Rho	XENTR|Xenbase=XB-GENE-941426|UniProtKB=Q28HZ4	Novel Rho protein	ISS	10556059	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	XENTR|Xenbase=XB-GENE-484003|UniProtKB=Q6P365	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	HUMAN|HGNC=10935|UniProtKB=Q05940	Synaptic vesicular amine transporter	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00029	Huntington disease	P00775	Rac	CAEEL|WormBase=WBGene00000390|UniProtKB=Q05062	Cell division control protein 42 homolog	TAS			PTHR24072:SF192	CDC42 HOMOLOG
P00010	B cell activation	P00398	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00053	T cell activation	P01305	Calmodulin	BOVIN|Ensembl=ENSBTAG00000001575|UniProtKB=F1N6C0	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF311	CALMODULIN
P05913	Enkephalin release	P05972	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00059	p53 pathway	G04694	p110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000017328|UniProtKB=Q5DRF0	Protocadherin alpha-2	ISS	8120095	PubMed	PTHR24028:SF60	PROTOCADHERIN ALPHA-2
P00056	VEGF signaling pathway	P01414	PLC-gamma	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MOUSE|MGI=MGI=1915201|UniProtKB=Q922F4	Tubulin beta-6 chain	ISS	12932731	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	HUMAN|HGNC=3023|UniProtKB=P14416	D(2) dopamine receptor	ISS	11248120	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	HUMAN|HGNC=7884|UniProtKB=Q99466	Neurogenic locus notch homolog protein 4	IDA	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P00011	Blood coagulation	P00440	ATIII	PANTR|Ensembl=ENSPTRG00000001701|UniProtKB=H2Q0N0	Uncharacterized protein	ISS	576554	gi	PTHR11461:SF53	ANTITHROMBIN-III
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	BRAFL|Gene=BRAFLDRAFT_59748|UniProtKB=C3ZEW2	Putative uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF263	SUBFAMILY NOT NAMED
P00059	p53 pathway	P04635	Sumo-1 ligase	XENTR|Xenbase=XB-GENE-1004211|UniProtKB=Q6DK72	Small ubiquitin-related modifier 3	ISS			PTHR10562:SF50	SMALL UBIQUITIN-RELATED MODIFIER 3
P06587	Nicotine pharmacodynamics pathway	P06606	ADCY2	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04392	P53 pathway feedback loops 1	P04539	p53	PANTR|Ensembl=ENSPTRG00000008703|UniProtKB=H2QC53	Cellular tumor antigen p53	ISS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00030	Hypoxia response via HIF activation	P00817	TOR	BOVIN|Ensembl=ENSBTAG00000015325|UniProtKB=E1BFB4	Uncharacterized protein	ISS	7518356	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	RAT|RGD=2322532|UniProtKB=Q561K3	Interleukin 13 receptor, alpha 1	IDA	11573960	PubMed	PTHR23036:SF89	INTERLEUKIN-13 RECEPTOR SUBUNIT ALPHA-1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MACMU|Ensembl=ENSMMUG00000016428|UniProtKB=F7GU00	Metabotropic glutamate receptor 1 isoform alpha	ISS	8314195	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	IXOSC|EnsemblGenome=ISCW014549|UniProtKB=B7QGY5	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	TAKRU|Ensembl=ENSTRUG00000016101|UniProtKB=H2UW32	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00030	Hypoxia response via HIF activation	P00819	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	MONDO|Ensembl=ENSMODG00000009988|UniProtKB=F6UST7	Uncharacterized protein	ISS	2433589	PubMed	PTHR11767:SF17	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	IC	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04395	Vasopressin synthesis	P04589	Signal Peptidase	ARATH|TAIR=AT5G27430|UniProtKB=Q53YF3	Signal peptidase complex subunit 3B	IC	1546959	PubMed	PTHR12804:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 3
P00008	Axon guidance mediated by Slit/Robo	P00346	Sdf1	XENTR|Xenbase=XB-GENE-919853|UniProtKB=Q5EBF6	Stromal cell-derived factor 1	ISS			PTHR18837:SF3	STROMAL CELL-DERIVED FACTOR 1
P04393	Ras Pathway	P04552	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	HUMAN|HGNC=2509|UniProtKB=P35221	Catenin alpha-1	TAS	10456847	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00036	Interleukin signaling pathway	P00983	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	HUMAN|HGNC=17793|UniProtKB=Q9UEU0	Vesicle transport through interaction with t-SNAREs homolog 1B	ISS	14570579	PubMed	PTHR21230:SF26	VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1B
P00010	B cell activation	P00402	Jnk	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04395	Vasopressin synthesis	P04589	Signal Peptidase	YEAST|SGD=S000001461|UniProtKB=P15367	Signal peptidase complex catalytic subunit SEC11	IC	2092035	PubMed	PTHR10806:SF6	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11
P00036	Interleukin signaling pathway	P00973	PKB	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000000440|UniProtKB=H2PYH8	Uncharacterized protein	ISS	11259487	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	RCA	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04393	Ras Pathway	P04546	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95816|UniProtKB=B1AS29	Glutamate receptor ionotropic, kainate 3	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00021	FGF signaling pathway	P00644	p38	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	IGI	10995439	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00050	Plasminogen activating cascade	P01244	PAI-2	PANTR|Ensembl=ENSPTRG00000023897|UniProtKB=H2QEN1	Uncharacterized protein	ISS	4505595	gi	PTHR11461:SF61	PLASMINOGEN ACTIVATOR INHIBITOR 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05918	p38 MAPK pathway	P06035	TAB1	MACMU|Ensembl=ENSMMUG00000012103|UniProtKB=F7H8X1	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform alpha	ISS	10838074	PubMed	PTHR13832:SF533	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02727	Androgen/estrogene/progesterone biosynthesis	P02829	Cholesterol acyltransferase	CANLF|Ensembl=ENSCAFG00000013894|UniProtKB=F1PUL0	O-acyltransferase	ISS	11948213	PubMed	PTHR10408:SF6	STEROL O-ACYLTRANSFERASE 1
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00029	Huntington disease	P00790	beta-Tubulin	XENTR|Xenbase=XB-GENE-6259095|UniProtKB=Q5BL39	Tubulin, beta 2	ISS	12932731	PubMed	PTHR11588:SF93	SUBFAMILY NOT NAMED
P06959	CCKR signaling map	G07280	CCND1	HUMAN|HGNC=1582|UniProtKB=P24385	G1/S-specific cyclin-D1	RCA	17167838	PubMed	PTHR10177:SF67	G1/S-SPECIFIC CYCLIN-D1
P04393	Ras Pathway	P04558	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	IDA	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00012	Cadherin signaling pathway	P00470	F-actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g234494|UniProtKB=A7RU31	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04393	Ras Pathway	P04546	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00047	PDGF signaling pathway	P01163	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00046	Oxidative stress response	P01131	MKP5	PANTR|Ensembl=ENSPTRG00000020152|UniProtKB=H2QW05	Uncharacterized protein	ISS			PTHR10159:SF112	DUAL SPECIFICITY PROTEIN PHOSPHATASE 26
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	MACMU|Ensembl=ENSMMUG00000020322|UniProtKB=F6WHL1	Fructose-bisphosphate aldolase	ISS	7768978	PubMed	PTHR11627:SF3	FRUCTOSE-BISPHOSPHATE ALDOLASE C
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	10891487	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00021	FGF signaling pathway	P00633	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P02778	Sulfate assimilation	P03164	Adenylylsulfate kinase	STRCO|Gene=CAC33944|UniProtKB=Q9ADG4	Adenylyl-sulfate kinase	ISS			PTHR42700:SF1	SULFATE ADENYLYLTRANSFERASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00053	T cell activation	P01319	PAK	MOUSE|MGI=MGI=1339975|UniProtKB=O88643	Serine/threonine-protein kinase PAK 1	IDA	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00023	General transcription regulation	P00658	TBP-associated factors	MACMU|Ensembl=ENSMMUG00000009140|UniProtKB=F7E5B3	Adenylate kinase isoenzyme 6 isoform a	ISS			PTHR12595:SF8	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 9
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	MONDO|Ensembl=ENSMODG00000018170|UniProtKB=F7CCD5	Uncharacterized protein	ISS	10683140	PubMed	PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05925	beta-ARR1	HUMAN|HGNC=711|UniProtKB=P49407	Beta-arrestin-1	RCA	11742073	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P05913	Enkephalin release	P05974	G-Protein (i)	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	IC	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00005	Angiogenesis	P00206	Wnt	DROME|FlyBase=FBgn0004360|UniProtKB=P28465	Protein Wnt-2	ISS	8717036	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00010	B cell activation	P00373	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	HUMAN|HGNC=1077|UniProtKB=O00238	Bone morphogenetic protein receptor type-1B	TAS	10683140	PubMed	PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P00006	Apoptosis signaling pathway	P00274	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00012	Cadherin signaling pathway	P00477	GSK3beta	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00012	Cadherin signaling pathway	P00463	betacatenin	STRPU|EnsemblGenome=SPU_009155|UniProtKB=W4Y0D3	Uncharacterized protein	ISS			PTHR23315:SF233	ARMADILLO SEGMENT POLARITY PROTEIN
P00056	VEGF signaling pathway	P01423	p38MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=1197020|UniProtKB=O35468	Protein Wnt-9b	IDA	11266476	PubMed	PTHR12027:SF84	PROTEIN WNT-9B
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00386	Calcineurin	PANTR|Ensembl=ENSPTRG00000016315|UniProtKB=H2QPY6	Serine/threonine-protein phosphatase	ISS	12015605	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IDA	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00034	Integrin signalling pathway	P00907	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	DANRE|Ensembl=ENSDARG00000079469|UniProtKB=A0A0G2KWQ6	Uncharacterized protein	ISS	11055438	PubMed	PTHR10117:SF9	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 7
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ARATH|TAIR=AT3G46520|UniProtKB=P53497	Actin-12	IC	11889126	PubMed	PTHR11937:SF276	ACTIN-12
P00010	B cell activation	P00367	NFAT	MACMU|Ensembl=ENSMMUG00000003370|UniProtKB=F7E8G2	Uncharacterized protein	ISS	12787506	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MOUSE|MGI=MGI=95823|UniProtKB=Q03391	Glutamate receptor ionotropic, NMDA 2D	ISS	14698601	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	RAT|RGD=3238|UniProtKB=P01179	Oxytocin-neurophysin 1	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P05731	GABA-B receptor II signaling	P05752	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00203	Erk	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00206	Wnt	MACMU|Ensembl=ENSMMUG00000007765|UniProtKB=F7CW57	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P02725	Allantoin degradation	P02822	Allantoinase	ANOGA|EnsemblGenome=AGAP000239|UniProtKB=Q7QF02	AGAP000239-PA	ISS			PTHR43668:SF2	ALLANTOINASE
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	DANRE|ZFIN=ZDB-GENE-030131-8783|UniProtKB=Q52WY2	Ras-like protein Cdc42a	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00004	Alzheimer disease-presenilin pathway	P00148	Erb-B4 N-terminal fragment	PANTR|Ensembl=ENSPTRG00000012883|UniProtKB=H2QJC5	Receptor protein-tyrosine kinase	ISS	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00056	VEGF signaling pathway	P01401	HIF-1	RAT|RGD=61928|UniProtKB=O35800	Hypoxia-inducible factor 1-alpha	ISS	14526383	PubMed	PTHR23043:SF7	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	TAS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=103077|UniProtKB=Q64704	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00053	T cell activation	P01331	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00052	TGF-beta signaling pathway	P01275	P38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	IDA	7600581	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00757	beta-arrestin	PANTR|Ensembl=ENSPTRG00000013052|UniProtKB=H2QJM8	Uncharacterized protein	ISS	11742073	PubMed	PTHR11792:SF15	S-ARRESTIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	94313981	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	G04690	PAG608	CANLF|Ensembl=ENSCAFG00000011081|UniProtKB=E2R5Y8	Uncharacterized protein	ISS			PTHR23067:SF5	ZINC FINGER MATRIN-TYPE PROTEIN 3
P00019	Endothelin signaling pathway	P00575	furin	MACMU|Ensembl=ENSMMUG00000004657|UniProtKB=G7MVY8	Furin	ISS	10956649	PubMed	PTHR42884:SF1	FURIN
P00021	FGF signaling pathway	P00631	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12748278	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04393	Ras Pathway	P04550	Ral	MACMU|Ensembl=ENSMMUG00000000462|UniProtKB=F6YQU1	Uncharacterized protein	ISS	7687439	PubMed	PTHR24070:SF199	RAS-RELATED PROTEIN RAL-B
P00049	Parkinson disease	P01212	p38 MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00645	Rac	DICDI|dictyBase=DDB_G0279605|UniProtKB=P34148	Rho-related protein racB	ISS	11973360	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00048	PI3 kinase pathway	P01185	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00047	PDGF signaling pathway	P01160	IP3 receptor	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12880387	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00034	Integrin signalling pathway	P00912	Arp2/3	RAT|RGD=2155|UniProtKB=O88656	Actin-related protein 2/3 complex subunit 1B	IPI	12932731	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00034	Integrin signalling pathway	P00944	Actin	ORNAN|Ensembl=ENSOANG00000007581|UniProtKB=F6QWB7	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P02721	ATP synthesis	P02791	F1 alpha	ARATH|TAIR=ATCG00120|UniProtKB=P56757	ATP synthase subunit alpha, chloroplastic	ISS	2443718	PubMed	PTHR42875:SF2	ATP SYNTHASE SUBUNIT ALPHA, CHLOROPLASTIC
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00021	FGF signaling pathway	P00623	FGF	BOVIN|Ensembl=ENSBTAG00000044043|UniProtKB=E1BP37	Fibroblast growth factor	ISS	11900978	PubMed	PTHR11486:SF72	FIBROBLAST GROWTH FACTOR 20
P04393	Ras Pathway	P04559	Rac	CHICK|Ensembl=ENSGALG00000002859|UniProtKB=F6UBD2	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00019	Endothelin signaling pathway	P00566	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IGI	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04546	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IDA	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02918	dUTP pyrophosphatase	ARATH|TAIR=AT3G46940|UniProtKB=Q9STG6	Deoxyuridine 5'-triphosphate nucleotidohydrolase	ISS			PTHR11241:SF0	BCDNA.LD08534
P00016	Cytoskeletal regulation by Rho GTPase	P00507	Rho	CHICK|Ensembl=ENSGALG00000016485|UniProtKB=O93468	GTP-binding protein	ISS	11973360	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P02721	ATP synthesis	P02794	F1 beta	PANTR|Ensembl=ENSPTRG00000005107|UniProtKB=H2Q695	ATP synthase subunit beta	ISS	2896550	PubMed	PTHR15184:SF44	ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00029	Huntington disease	P00782	alpha-Adaptin	ARATH|TAIR=AT5G22780|UniProtKB=Q8LPK4	AP-2 complex subunit alpha-2	IDA	11532990	PubMed	PTHR22780:SF4	AP-2 COMPLEX SUBUNIT ALPHA-2
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00021	FGF signaling pathway	P00632	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	BOVIN|Ensembl=ENSBTAG00000001067|UniProtKB=E1BAB4	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00016	Cytoskeletal regulation by Rho GTPase	P00521	Profilin	ARATH|TAIR=AT4G29350|UniProtKB=Q42418	Profilin-2	ISS			PTHR11604:SF7	PROFILIN-1-RELATED
P00057	Wnt signaling pathway	P01443	Phospholipase C	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P02770	Pyridoxal phosphate salvage pathway	P03122	Pyridoxamine kinase	RAT|RGD=1566085|UniProtKB=D3Z8P5	Protein RGD1566085	ISS	20344886	gi	PTHR10534:SF2	PYRIDOXAL KINASE
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	HUMAN|HGNC=1389|UniProtKB=Q00975	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	8386525	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P02756	N-acetylglucosamine metabolism	P03035	Phosphoglucosamine mutase	FUSNN|EnsemblGenome=FN0366|UniProtKB=Q8R6A7	Phosphoglucosamine mutase	ISS			PTHR42946:SF1	PHOSPHOGLUCOSAMINE MUTASE FAMILY PROTEIN
P00047	PDGF signaling pathway	P01167	Ets	CANLF|Ensembl=ENSCAFG00000008512|UniProtKB=E2R3L5	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF195	GA-BINDING PROTEIN ALPHA CHAIN
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	BOVIN|Ensembl=ENSBTAG00000004322|UniProtKB=O77628	Proto-oncogene c-Fos	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00048	PI3 kinase pathway	P01177	P110ACT	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	TAS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	ORNAN|Ensembl=ENSOANG00000005936|UniProtKB=F6PQC9	Uncharacterized protein	ISS	10476970	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MACMU|Ensembl=ENSMMUG00000006921|UniProtKB=F7EV26	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	IC	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01188	Gbetagamma	DAPPU|EnsemblGenome=DAPPUDRAFT_206575|UniProtKB=E9FUX0	Guanine nucleotide binding protein, beta subunit	ISS	9740024	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00059	p53 pathway	P04633	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00209	FAK	CAEBR|Gene=CBG10801|UniProtKB=A8XBU1	Protein CBR-KIN-32	ISS			PTHR24418:SF367	FOCAL ADHESION KINASE, ISOFORM D
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MOUSE|MGI=MGI=95688|UniProtKB=P43027	Growth/differentiation factor 5	TAS	9759503	PubMed	PTHR11848:SF44	GROWTH/DIFFERENTIATION FACTOR 5
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00057	Wnt signaling pathway	P01446	Calcineurin	ORYSJ|EnsemblGenome=OS03G0626800|UniProtKB=Q75LU8	Calcineurin B-like protein 3	ISS	12015605	PubMed	PTHR23056:SF44	CALCINEURIN B-LIKE PROTEIN 5
P00005	Angiogenesis	P00211	GSK3beta	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	SCHPO|PomBase=SPBC26H8.07c|UniProtKB=P05219	Tubulin beta chain	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00036	Interleukin signaling pathway	P00973	PKB	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01332	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00054	Toll receptor signaling pathway	P01338	IkappaB	MOUSE|MGI=MGI=104741|UniProtKB=Q9Z1E3	NF-kappa-B inhibitor alpha	ISS	10811867	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	ORNAN|Ensembl=ENSOANG00000013961|UniProtKB=F6VPY1	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00004	Alzheimer disease-presenilin pathway	P00113	Erb-B4 transmembrane fragment	MACMU|Ensembl=ENSMMUG00000001674|UniProtKB=F7G3H1	Receptor protein-tyrosine kinase	ISS	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00018	EGF receptor signaling pathway	P00556	PLCgamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00034	Integrin signalling pathway	P00951	Jnk	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00182	p38MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04657	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CANLF|Ensembl=ENSCAFG00000004930|UniProtKB=E2RFB5	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00034	Integrin signalling pathway	P00907	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	IDA	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	ORYSJ|EnsemblGenome=OS04G0659100|UniProtKB=P14655	Glutamine synthetase, chloroplastic	ISS			PTHR20852:SF53	GLUTAMINE SYNTHETASE, CHLOROPLASTIC/MITOCHONDRIAL
P00012	Cadherin signaling pathway	P00471	Cadherin	CANLF|Ensembl=ENSCAFG00000018973|UniProtKB=E2R971	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF99	CADHERIN-9
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	RCA	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P02769	Purine metabolism	P03118	Guanine Deaminase	RAT|RGD=621617|UniProtKB=Q9WTT6	Guanine deaminase	NAS	11837778	gi	PTHR11271:SF6	GUANINE DEAMINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ORYSJ|EnsemblGenome=OS05G0438800|UniProtKB=Q75HX0	Actin	IC	10974003	PubMed	PTHR11937:SF248	SUBFAMILY NOT NAMED
P02779	Thiamin biosynthesis	P03170	Hydroxymethylpyrimidine phosphate kinase	DEIRA|EnsemblGenome=DR_A0171|UniProtKB=Q9RYY2	Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase	ISS			PTHR20858:SF17	HYDROXYMETHYLPYRIMIDINE/PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	RCA	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01414	PLC-gamma	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00235	c-Fos	PANTR|Ensembl=ENSPTRG00000006553|UniProtKB=A5A6H0	C-fos	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	HUMAN|HGNC=11442|UniProtKB=O15400	Syntaxin-7	IC	14570579	PubMed	PTHR19957:SF90	SYNTAXIN-7
P00029	Huntington disease	P00786	ARF	MOUSE|MGI=MGI=99431|UniProtKB=P84078	ADP-ribosylation factor 1	ISS	12932731	PubMed	PTHR11711:SF234	ADP-RIBOSYLATION FACTOR 1
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00036	Interleukin signaling pathway	P00973	PKB	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01072	CHT1	BOVIN|Ensembl=ENSBTAG00000004352|UniProtKB=Q2KI26	Solute carrier family 5 (Choline transporter), member 7	ISS	12675135	PubMed	PTHR11819:SF129	HIGH AFFINITY CHOLINE TRANSPORTER 1
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02742	Tetrahydrofolate biosynthesis	P02944	Phosphoribosylglycinamide formyltransferase	STRCO|Gene=CAB92676|UniProtKB=Q9KY51	Phosphoribosylglycinamide formyltransferase	ISS			PTHR43369:SF2	PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	RCA	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00047	PDGF signaling pathway	P01160	IP3 receptor	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00010	B cell activation	P00401	jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00053	T cell activation	P01322	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02748	Isoleucine biosynthesis	P02997	Acetolactate synthase	METAC|EnsemblGenome=MA_3792|UniProtKB=Q8TJJ2	Acetolactate synthase	ISS			PTHR18968:SF13	ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	DANRE|ZFIN=ZDB-GENE-030131-8783|UniProtKB=Q52WY2	Ras-like protein Cdc42a	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	HALSA|EnsemblGenome=VNG_1814G|UniProtKB=Q9HP43	Carbamoyl-phosphate synthase large chain	ISS			PTHR11405:SF5	CAD PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=94925|UniProtKB=P30728	D(3) dopamine receptor	IDA	2039532	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00034	Integrin signalling pathway	P00951	Jnk	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02775	Salvage pyrimidine ribonucleotides	P03149	Cytidine kinase	MOUSE|MGI=MGI=1915806|UniProtKB=Q91YL3	Uridine-cytidine kinase-like 1	ISS			PTHR10285:SF68	URIDINE-CYTIDINE KINASE-LIKE 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	TAKRU|Ensembl=ENSTRUG00000007989|UniProtKB=P68140	Actin, alpha skeletal muscle A	IDA	14684598	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	TAS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00053	T cell activation	P01294	NFAT	MOUSE|MGI=MGI=1920431|UniProtKB=Q8K120	Nuclear factor of activated T-cells, cytoplasmic 4	IGI	9133421	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=14270|UniProtKB=Q8TAB3	Protocadherin-19	ISS	8120095	PubMed	PTHR24028:SF40	PROTOCADHERIN-19
P00021	FGF signaling pathway	P00633	Ras	MONDO|Ensembl=ENSMODG00000025248|UniProtKB=F7F5X1	Uncharacterized protein	ISS	9869449	PubMed	PTHR24070:SF186	GTPASE KRAS
P00018	EGF receptor signaling pathway	P00558	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00012	Cadherin signaling pathway	P00470	F-actin	DANRE|ZFIN=ZDB-GENE-000329-1|UniProtKB=Q7ZVI7	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00010	B cell activation	P00384	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00054	Toll receptor signaling pathway	P01367	MKK3	BOVIN|Ensembl=ENSBTAG00000010576|UniProtKB=A4IFH7	MAP2K3 protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	ORNAN|Ensembl=ENSOANG00000002061|UniProtKB=F7ANC6	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	BOVIN|Ensembl=ENSBTAG00000047202|UniProtKB=G3N3K3	Uncharacterized protein	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	TAS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	PANTR|Ensembl=ENSPTRG00000001749|UniProtKB=H2Q0Q4	Uncharacterized protein	ISS	14507926	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P04395	Vasopressin synthesis	P04590	Vasopressin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00015	Circadian clock system	G01497	cry	CANLF|Ensembl=ENSCAFG00000009379|UniProtKB=F1PNC9	Uncharacterized protein	ISS	10217146	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00034	Integrin signalling pathway	P00951	Jnk	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	BOVIN|Ensembl=ENSBTAG00000008059|UniProtKB=P41984	Muscarinic acetylcholine receptor M3	IDA	8100450	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000002647|UniProtKB=F7DIB7	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IDA	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	RAT|RGD=69424|UniProtKB=Q99P84	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	7822322	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00875	GEF	PANTR|Ensembl=ENSPTRG00000010378|UniProtKB=H2QF58	Uncharacterized protein	ISS	10661401	PubMed	PTHR22826:SF112	PROTO-ONCOGENE VAV
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	ISS	94280860	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000012311|UniProtKB=H2QIH3	Uncharacterized protein	ISS			PTHR24245:SF4	G-PROTEIN COUPLED RECEPTOR 45-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	RAT|RGD=620351|UniProtKB=P18265	Glycogen synthase kinase-3 alpha	ISS	2164470	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04376	5HT4 type receptor mediated signaling pathway	P04426	K+ channel	MOUSE|MGI=MGI=1100509|UniProtKB=O35111	Potassium channel subfamily K member 3	ISS	11875121	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00029	Huntington disease	P00805	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	IC	9199552	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT1G07880|UniProtKB=Q9LQQ9	Mitogen-activated protein kinase 13	IDA	9836510	gi	PTHR24055:SF185	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	PHYIT|EnsemblGenome=PITG_06514|UniProtKB=D0N511	Calmodulin	ISS			PTHR23050:SF245	AT16150P-RELATED
P02738	De novo purine biosynthesis	P02889	dGDP kinase	CHLTR|EnsemblGenome=CT_500|UniProtKB=O84508	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00036	Interleukin signaling pathway	P00975	RasGAP	HUMAN|HGNC=9871|UniProtKB=P20936	Ras GTPase-activating protein 1	IC	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01437	TCF	DANRE|ZFIN=ZDB-GENE-980605-30|UniProtKB=Q9YHE8	Transcription factor 7-like 1-A	IDA	9118222	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04393	Ras Pathway	P04559	Rac	XENTR|Xenbase=XB-GENE-494950|UniProtKB=F6YFT0	Uncharacterized protein (Fragment)	ISS			PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00057	Wnt signaling pathway	P01438	PP2A	BOVIN|Ensembl=ENSBTAG00000019784|UniProtKB=A4FV68	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	ISS	10092233	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00514	MLCK	CHICK|Ensembl=ENSGALG00000006273|UniProtKB=E1BX17	Uncharacterized protein	TAS	11157482	PubMed	PTHR45210:SF1	MYOSIN LIGHT CHAIN KINASE 2, SKELETAL/CARDIAC MUSCLE
P00005	Angiogenesis	P00238	Ras	DANRE|ZFIN=ZDB-GENE-040808-67|UniProtKB=Q6AZA4	K-ras	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	IC	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00005	Angiogenesis	P00180	Dok-R	MOUSE|MGI=MGI=893587|UniProtKB=P97465	Docking protein 1	ISS			PTHR21258:SF46	DOCKING PROTEIN 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06759	IRS	MOUSE|MGI=MGI=99454|UniProtKB=P35569	Insulin receptor substrate 1	RCA	5031805	gi	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P04393	Ras Pathway	P04578	Rho	MONDO|Ensembl=ENSMODG00000012981|UniProtKB=F7CS91	Uncharacterized protein	ISS	15668138	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	HUMAN|HGNC=144|UniProtKB=P63261	Actin, cytoplasmic 2	IC	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00047	PDGF signaling pathway	P01145	c-fos	RAT|RGD=1559787|UniProtKB=D3ZHH8	Protein Srf	ISS			PTHR11945:SF221	SERUM RESPONSE FACTOR
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	MACMU|Ensembl=ENSMMUG00000009781|UniProtKB=F6ZH51	Uncharacterized protein	ISS			PTHR10024:SF45	SYNAPTOTAGMIN-6
P00018	EGF receptor signaling pathway	P00542	EGFR	MACMU|Gene=EGFR|UniProtKB=P55245	Epidermal growth factor receptor	ISS	21100872	PubMed	PTHR24416:SF91	EPIDERMAL GROWTH FACTOR RECEPTOR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	DANRE|Ensembl=ENSDARG00000059090|UniProtKB=E7FDL0	Uncharacterized protein	ISS	12441358	PubMed	PTHR24229:SF75	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00807	Actin	CANLF|Ensembl=ENSCAFG00000015708|UniProtKB=F2Z4N0	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00053	T cell activation	P01318	PKC-theta	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00006	Apoptosis signaling pathway	P00297	NFkappaB	PANTR|Ensembl=ENSPTRG00000003889|UniProtKB=G2HHW9	Transcription factor p65	ISS	10049353	PubMed	PTHR24169:SF1	TRANSCRIPTION FACTOR P65
P00006	Apoptosis signaling pathway	P00269	MAPK	YEAST|SGD=S000003272|UniProtKB=P14681	Mitogen-activated protein kinase KSS1	ISS	9836510	gi	PTHR24055:SF338	MITOGEN-ACTIVATED PROTEIN KINASE KSS1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT2G42880|UniProtKB=Q9SJG9	Mitogen-activated protein kinase 20	IDA			PTHR24055:SF158	MITOGEN-ACTIVATED PROTEIN KINASE 20
P00048	PI3 kinase pathway	P01204	GPCR	HUMAN|HGNC=9593|UniProtKB=P34995	Prostaglandin E2 receptor EP1 subtype	IC	14607241	PubMed	PTHR11866:SF3	PROSTAGLANDIN E2 RECEPTOR EP1 SUBTYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00036	Interleukin signaling pathway	P00962	ELK	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	IC	3183861	gi	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00053	T cell activation	P01300	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05916	Opioid prodynorphin pathway	G06049	preprodynorphin	MACMU|Ensembl=ENSMMUG00000009984|UniProtKB=F6R267	Beta-neoendorphin-dynorphin	ISS	131330	OMIM	PTHR11438:SF4	PROENKEPHALIN-B
P00057	Wnt signaling pathway	P01428	Frizzled	HUMAN|HGNC=4043|UniProtKB=Q13467	Frizzled-5	IDA	11212302	PubMed	PTHR11309:SF126	FRIZZLED-5
P02750	Lipoate_biosynthesis	P03003	Lipoyl-protein ligase	SYNY3|EnsemblGenome=BAA18623|UniProtKB=P74519	Octanoyltransferase	ISS			PTHR10993:SF18	SUBFAMILY NOT NAMED
P00053	T cell activation	P01332	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	MACMU|Ensembl=ENSMMUG00000011852|UniProtKB=F7H4T8	Receptor protein serine/threonine kinase	ISS	10683140	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P00019	Endothelin signaling pathway	P00589	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	IGI	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	CANLF|Ensembl=ENSCAFG00000005415|UniProtKB=F1PQM2	Uncharacterized protein	ISS	9388255	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	94280860	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04398	p53 pathway feedback loops 2	G04714	PTEN	DANRE|ZFIN=ZDB-GENE-030131-3776|UniProtKB=E7FC59	Uncharacterized protein	ISS			PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	MOUSE|MGI=MGI=96522|UniProtKB=P31266	Recombining binding protein suppressor of hairless	NAS	12145413	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00029	Huntington disease	P00790	beta-Tubulin	PRIPA|Gene=PPA21756|UniProtKB=H3FHK9	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF255	TUBA7L PROTEIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000013632|UniProtKB=E1B965	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00004	Alzheimer disease-presenilin pathway	P00165	E-cadherin N-terminal fragment	MOUSE|MGI=MGI=88354|UniProtKB=P09803	Cadherin-1	TAS	12834808	PubMed	PTHR24027:SF319	CADHERIN-1
P02788	Xanthine and guanine salvage pathway	P03247	Xanthine phosphoribosyl transferase	RAT|RGD=2826|UniProtKB=P27605	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF6	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01242	Casein kinase I	PANTR|Ensembl=ENSPTRG00000014365|UniProtKB=H2R0C8	Casein kinase 1, epsilon	ISS	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MONDO|Ensembl=ENSMODG00000020204|UniProtKB=F6SED9	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P02763	Peptidoglycan biosynthesis	P03084	UDP-N-acetylmuramoylalanyl-D-glutamate 2,6-diaminopimelate ligase	RHOBA|EnsemblGenome=RB6114|UniProtKB=Q7UQT1	Probable UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase	ISS			PTHR23135:SF4	UDP-N-ACETYLMUAMOYLALANYL-D-GLUTAMATE-2,6-DIAMINOPIMELATE LIGASE-RELATED
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	CANLF|Ensembl=ENSCAFG00000003123|UniProtKB=E2R3R6	Uncharacterized protein	ISS	10683140	PubMed	PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	14526383	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BRAFL|Gene=BRAFLDRAFT_220697|UniProtKB=C3ZSF0	Putative uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MOUSE|MGI=MGI=3710243|UniProtKB=A2AQP0	Myosin-7B	ISS	10938134	PubMed	PTHR13140:SF358	MYOSIN-7B
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00019	Endothelin signaling pathway	P00586	Gq	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CHLRE|EnsemblGenome=CHLREDRAFT_193901|UniProtKB=Q9FXT7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	IGI	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000020947|UniProtKB=F7CY46	Uncharacterized protein	ISS	12181435	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00006	Apoptosis signaling pathway	P00310	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05730	Endogenous cannabinoid signaling	P05746	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05731	GABA-B receptor II signaling	P05755	Gbeta	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00029	Huntington disease	P00778	NMDA receptor	HUMAN|HGNC=16767|UniProtKB=Q8TCU5	Glutamate receptor ionotropic, NMDA 3A	IDA	14698601	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00048	PI3 kinase pathway	P01189	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00049	Parkinson disease	P01227	20S proteasome	ORYSJ|EnsemblGenome=OS02G0634900|UniProtKB=Q6H852	Proteasome subunit alpha type	TAS	12859888	PubMed	PTHR11599:SF16	PROTEASOME SUBUNIT ALPHA TYPE-2
P02723	Adenine and hypoxanthine salvage pathway	P02810	Adenine phosphoribosyl transferase	ARATH|TAIR=AT4G12440|UniProtKB=Q9SU38	Adenine phosphoribosyltransferase 4	ISS			PTHR11776:SF7	ADENINE PHOSPHORIBOSYLTRANSFERASE 3-RELATED
P00053	T cell activation	P01307	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00048	PI3 kinase pathway	P01192	p110	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00067	MAO	BOVIN|Gene=MAOB|UniProtKB=P56560	Amine oxidase [flavin-containing] B	ISS	90344230	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P05913	Enkephalin release	P05974	G-Protein (i)	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CAEEL|WormBase=WBGene00000200|UniProtKB=P53489	Actin-related protein 2	IDA	10974003	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P04393	Ras Pathway	P04552	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00050	Plasminogen activating cascade	P01243	uPA	MOUSE|MGI=MGI=97611|UniProtKB=P06869	Urokinase-type plasminogen activator	IGI	12591758	PubMed	PTHR24264:SF38	UROKINASE-TYPE PLASMINOGEN ACTIVATOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	BOVIN|Ensembl=ENSBTAG00000020887|UniProtKB=F1MP22	Uncharacterized protein	ISS	8386525	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DANRE|ZFIN=ZDB-GENE-000330-4|UniProtKB=Q1MTI1	Uncharacterized protein	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P04398	p53 pathway feedback loops 2	P04662	cyclin G	RAT|RGD=2295|UniProtKB=P39950	Cyclin-G1	ISS	7957050	PubMed	PTHR10177:SF59	CYCLIN-G1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000002775|UniProtKB=H2RB55	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00054	Toll receptor signaling pathway	P01352	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01432	Beta-Catenin	HUMAN|HGNC=2514|UniProtKB=P35222	Catenin beta-1	IDA	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	TAS	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00274	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	IC	10514528	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	CHICK|Ensembl=ENSGALG00000006576|UniProtKB=E1BUE5	Uncharacterized protein	ISS	20012997	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00056	VEGF signaling pathway	P01409	cPLA2	MONDO|Ensembl=ENSMODG00000011791|UniProtKB=F7CBU9	Phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00047	PDGF signaling pathway	P01142	p90RSK	MACMU|Ensembl=ENSMMUG00000005586|UniProtKB=F7G4I3	Ribosomal protein S6 kinase	ISS	9687510	PubMed	PTHR24351:SF115	RIBOSOMAL PROTEIN S6 KINASE ALPHA-5
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IDA	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00029	Huntington disease	P00780	Microtubule	IXOSC|EnsemblGenome=ISCW021482|UniProtKB=B7Q717	Beta-tubulin, putative (Fragment)	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P02728	Arginine biosynthesis	P02840	Argininosuccinate synthase	METJA|EnsemblGenome=MJ_0429|UniProtKB=Q60174	Argininosuccinate synthase	ISS			PTHR11587:SF2	ARGININOSUCCINATE SYNTHASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00029	Huntington disease	P00797	p53	MACMU|Ensembl=ENSMMUG00000008639|UniProtKB=P56424	Cellular tumor antigen p53	ISS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	HUMAN|HGNC=168|UniProtKB=P42025	Beta-centractin	IC	14684598	PubMed	PTHR11937:SF195	BETA-CENTRACTIN
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00005	Angiogenesis	P00187	beta catenin	CANLF|Ensembl=ENSCAFG00000005204|UniProtKB=B6V8E6	Catenin beta-1	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00053	T cell activation	P01308	ZAP-70	MACMU|Ensembl=ENSMMUG00000021545|UniProtKB=F7FAI7	Tyrosine-protein kinase	ISS	1423621	PubMed	PTHR24418:SF369	TYROSINE-PROTEIN KINASE ZAP-70
P00056	VEGF signaling pathway	P01418	Paxillin	MACMU|Ensembl=ENSMMUG00000011713|UniProtKB=F7HC66	Leupaxin isoform 2	ISS			PTHR24216:SF23	LEUPAXIN
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	DANRE|ZFIN=ZDB-GENE-020419-18|UniProtKB=Q8JHG4	TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor	ISS			PTHR12228:SF0	TAF7 RNA POLYMERASE II, TATA BOX BINDING PROTEIN  TBP -ASSOCIATED FACTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IDA	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00053	T cell activation	P01305	Calmodulin	CHICK|Gene_ORFName=RCJMB04_24e7|UniProtKB=P62149	Calmodulin	ISS	3885394	PubMed	PTHR23050:SF311	CALMODULIN
P00059	p53 pathway	G04694	p110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00590	IP3 R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00049	Parkinson disease	P01230	Src kinase	XENTR|Xenbase=XB-GENE-5771921|UniProtKB=F6UTP2	Tyrosine-protein kinase	ISS	7687537	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00035	Interferon-gamma signaling pathway	P00958	PIAS	PANTR|Ensembl=ENSPTRG00000007210|UniProtKB=H2RH26	Uncharacterized protein	ISS	8682149	PubMed	PTHR10782:SF11	E3 SUMO-PROTEIN LIGASE PIAS1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	PANTR|Ensembl=ENSPTRG00000001112|UniProtKB=H2PZP2	Ras homolog gene family, member C	ISS	12090470	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	TAS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04393	Ras Pathway	P04542	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00009	Axon guidance mediated by netrin	P00366	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12960248	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	DANRE|ZFIN=ZDB-GENE-030616-53|UniProtKB=Q71E60	AMPA receptor subunit GluR3B	ISS	20112749	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	MACMU|Ensembl=ENSMMUG00000014498|UniProtKB=F7GEI8	Uncharacterized protein	ISS	11976940	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00036	Interleukin signaling pathway	P00990	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	CANLF|Ensembl=ENSCAFG00000019237|UniProtKB=E2R4W4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF319	ADENYLATE CYCLASE TYPE 9
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01322	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	CAEEL|WormBase=WBGene00000254|UniProtKB=P51559	Endoprotease bli-4	IDA			PTHR42884:SF18	ENDOPROTEASE BLI-4
P00018	EGF receptor signaling pathway	P00564	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	21244534	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00007	Axon guidance mediated by semaphorins	P00339	CRMP	CHICK|Ensembl=ENSGALG00000010490|UniProtKB=F1NNK9	Uncharacterized protein	ISS			PTHR11647:SF55	DIHYDROPYRIMIDINASE-RELATED PROTEIN 4
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00470	F-actin	MOUSE|MGI=MGI=87909|UniProtKB=P62737	Actin, aortic smooth muscle	IC	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00034	Integrin signalling pathway	P00936	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00021	FGF signaling pathway	P00639	Shc	MOUSE|MGI=MGI=98296|UniProtKB=P98083	SHC-transforming protein 1	IGI	8264585	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00053	T cell activation	P01322	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	IGI	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00566	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	IPI	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00056	VEGF signaling pathway	P01409	cPLA2	CHICK|Ensembl=ENSGALG00000005065|UniProtKB=P49147	Cytosolic phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00036	Interleukin signaling pathway	P00990	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01188	Gbetagamma	ARATH|TAIR=AT4G34460|UniProtKB=P49177	Guanine nucleotide-binding protein subunit beta	IC	11313908	PubMed	PTHR19850:SF48	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05913	Enkephalin release	P05972	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00047	PDGF signaling pathway	P01154	Ras	CHICK|Ensembl=ENSGALG00000016485|UniProtKB=O93468	GTP-binding protein	ISS	11973360	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00018	EGF receptor signaling pathway	P00547	PP2A	RAT|RGD=1305657|UniProtKB=A0A0G2JTA1	Protein Ppp2r5e	ISS	11007767	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06850	PKCs(3)	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	RCA	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	DROME|FlyBase=FBgn0004573|UniProtKB=P20905	5-hydroxytryptamine receptor 1	IDA	12441358	PubMed	PTHR24247:SF171	5-HYDROXYTRYPTAMINE RECEPTOR 1
P00049	Parkinson disease	P01235	Fyn kinase	CHICK|Gene=FYN|UniProtKB=Q05876	Tyrosine-protein kinase Fyn	IDA	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	RAT|RGD=69424|UniProtKB=Q99P84	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	15611108	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00557	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IGI	96009592	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00053	T cell activation	P01311	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	3449797	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00029	Huntington disease	P00807	Actin	TAKRU|Ensembl=ENSTRUG00000005447|UniProtKB=P68142	Actin, cytoplasmic 1	IDA	3487386	PubMed	PTHR11937:SF354	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	IC	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	CANLF|Ensembl=ENSCAFG00000015094|UniProtKB=F1PT97	Uncharacterized protein	ISS	12932731	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00021	FGF signaling pathway	P00644	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	IPI	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00047	PDGF signaling pathway	P01161	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	XENTR|Xenbase=XB-GENE-480347|UniProtKB=Q6P640	Actin, alpha cardiac muscle 1	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04393	Ras Pathway	P04552	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IDA	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00030	Hypoxia response via HIF activation	P00817	TOR	HUMAN|HGNC=3942|UniProtKB=P42345	Serine/threonine-protein kinase mTOR	TAS	14526383	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00057	Wnt signaling pathway	P01471	alpha-catenin	HUMAN|HGNC=2509|UniProtKB=P35221	Catenin alpha-1	IDA	9362521	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00013	Cell cycle	P00481	APC	MACMU|Ensembl=ENSMMUG00000001669|UniProtKB=F7G3J3	Anaphase-promoting complex subunit 2	ISS	7019327	gi	PTHR11932:SF5	ANAPHASE-PROMOTING COMPLEX SUBUNIT 2
P00045	Notch signaling pathway	P01104	Serrate	CHICK|Ensembl=ENSGALG00000011696|UniProtKB=F1NMD6	Delta-like protein	IEP	9032014	PubMed	PTHR44097:SF1	PROTEIN JAGGED-2
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	TAS	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P00053	T cell activation	P01300	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00571	Pro ET1-4	HUMAN|HGNC=3177|UniProtKB=P20800	Endothelin-2	ISS	12516960	PubMed	PTHR13874:SF9	ENDOTHELIN-2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PRIPA|Gene=PPA17339|UniProtKB=H3F5B4	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF352	ACTIN
P00025	Hedgehog signaling pathway	P00683	Slimb	XENTR|Xenbase=XB-GENE-486122|UniProtKB=F6XVN5	Uncharacterized protein (Fragment)	ISS	10074433	PubMed	PTHR44038:SF2	F-BOX/WD REPEAT-CONTAINING PROTEIN 1A
P04393	Ras Pathway	P04544	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8235613	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	MONDO|Ensembl=ENSMODG00000000129|UniProtKB=F6YB95	Uncharacterized protein	ISS	12145413	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	HUMAN|HGNC=2091|UniProtKB=P09497	Clathrin light chain B	ISS	11889126	PubMed	PTHR10639:SF2	CLATHRIN LIGHT CHAIN B
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00029	Huntington disease	P00790	beta-Tubulin	GIAIC|EnsemblGenome=GL50803_101291|UniProtKB=A8BEI6	Beta tubulin	TAS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00006	Apoptosis signaling pathway	P00297	NFkappaB	MOUSE|MGI=MGI=97312|UniProtKB=P25799	Nuclear factor NF-kappa-B p105 subunit	IDA	12574369	PubMed	PTHR24169:SF9	NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT
P00059	p53 pathway	G04697	B99	MACMU|Ensembl=ENSMMUG00000008136|UniProtKB=F7HGK9	Uncharacterized protein	ISS	20127556	gi	PTHR21584:SF10	G2 AND S PHASE-EXPRESSED PROTEIN 1
P00059	p53 pathway	P04633	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00965	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IC	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00944	Actin	XENTR|Xenbase=XB-GENE-490883|UniProtKB=Q6NVA9	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00321	HSP70	MOUSE|MGI=MGI=95835|UniProtKB=P20029	78 kDa glucose-regulated protein	ISS	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00034	Integrin signalling pathway	P00907	ERK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS			PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04585	TRH	PANTR|Ensembl=ENSPTRG00000018398|UniProtKB=H2QTD1	Glycoprotein hormones alpha chain	ISS			PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	CHICK|Ensembl=ENSGALG00000010273|UniProtKB=P48463	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01208	Hsp70	MONDO|Ensembl=ENSMODG00000019764|UniProtKB=F6WMM9	Uncharacterized protein	ISS	10934466	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00029	Huntington disease	P00786	ARF	HUMAN|HGNC=655|UniProtKB=P18085	ADP-ribosylation factor 4	IPI	12932731	PubMed	PTHR11711:SF110	ADP-RIBOSYLATION FACTOR 4
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	THAPS|Gene=Thaps8069|UniProtKB=B8C8B4	Tubulin beta	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00004	Alzheimer disease-presenilin pathway	P00114	actin	TRIVA|Gene=TVAG_054030|UniProtKB=A2G1K5	Actin	IDA			PTHR11937:SF155	ACTIN-5C-RELATED
P00034	Integrin signalling pathway	P00907	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P06664	Gonadotropin-releasing hormone receptor pathway	P06730	Pyk2	MOUSE|MGI=MGI=104908|UniProtKB=Q9QVP9	Protein-tyrosine kinase 2-beta	RCA	10753828	PubMed	PTHR24418:SF94	PROTEIN-TYROSINE KINASE 2-BETA
P00004	Alzheimer disease-presenilin pathway	P00162	Pro-BACE-1	HUMAN|HGNC=933|UniProtKB=P56817	Beta-secretase 1	IDA	10531052	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00050	Plasminogen activating cascade	P01250	MMP-13	RAT|RGD=620196|UniProtKB=P23097	Collagenase 3 (Fragment)	ISS	1383028	PubMed	PTHR10201:SF165	COLLAGENASE 3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02778	Sulfate assimilation	P03167	Sulfate adenylyltransferase	HUMAN|HGNC=8604|UniProtKB=O95340	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2	ISS			PTHR11055:SF16	BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE 2
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	IDA	9332390	PubMed	PTHR10202:SF13	PRESENILIN-2
P00054	Toll receptor signaling pathway	P01358	ERK1	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	NEUCR|EnsemblGenome=EFNCRG00000006013|UniProtKB=Q3Y3Z2	cAMP-dependent protein kinase type 3	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CANLF|Ensembl=ENSCAFG00000018634|UniProtKB=E2RFV2	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF253	TUBULIN BETA-4A CHAIN
P00047	PDGF signaling pathway	P01147	Nck	PANTR|Ensembl=ENSPTRG00000012316|UniProtKB=H2QIH7	NCK adaptor protein 2	ISS	12874226	PubMed	PTHR44108:SF1	CYTOPLASMIC PROTEIN NCK2
P00059	p53 pathway	P04630	PP2A	CANLF|Ensembl=ENSCAFG00000006453|UniProtKB=F6X958	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00030	Hypoxia response via HIF activation	P00817	TOR	CHICK|Ensembl=ENSGALG00000003339|UniProtKB=F1NUX4	Uncharacterized protein	ISS	14526383	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00010	B cell activation	P00371	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	SCHMA|EnsemblGenome=Smp_046600|UniProtKB=G4VLW2	Putative actin-1	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05730	Endogenous cannabinoid signaling	P05751	Galpha	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00010	B cell activation	P00398	IP3R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00056	VEGF signaling pathway	P01408	Akt/PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	IC	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00052	TGF-beta signaling pathway	P01275	P38	TAKRU|Ensembl=ENSTRUG00000008723|UniProtKB=H2TB66	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF331	SUBFAMILY NOT NAMED
P05731	GABA-B receptor II signaling	P05755	Gbeta	BOVIN|Ensembl=ENSBTAG00000006495|UniProtKB=P11017	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00012	Cadherin signaling pathway	P00467	alpha-catenin	DANRE|Ensembl=ENSDARG00000024785|UniProtKB=B7ZC77	Catenin alpha-2	ISS	1768802	PubMed	PTHR18914:SF29	CATENIN ALPHA-2
P06212	DPP-SCW signaling pathway	P06273	DPP full length	DROME|FlyBase=FBgn0000490|UniProtKB=P07713	Protein decapentaplegic	IEA	http://flybase.org/reports/FBgn0000490.html	Website	PTHR11848:SF234	PROTEIN DECAPENTAPLEGIC
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	176910	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05730	Endogenous cannabinoid signaling	P05746	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00570	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00009	Axon guidance mediated by netrin	P00359	NFAT	RAT|RGD=1307690|UniProtKB=D4A0I8	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (Predicted), isoform CRA_b	ISS	12015605	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00018	EGF receptor signaling pathway	P00543	ERK1-2	TRYB2|Gene=Tb10.61.0250|UniProtKB=Q387R2	Mitogen-activated protein kinase	ISS			PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P00046	Oxidative stress response	P01131	MKP5	PANTR|Ensembl=ENSPTRG00000013364|UniProtKB=H2RCB5	Uncharacterized protein	ISS			PTHR10159:SF30	DUAL SPECIFICITY PROTEIN PHOSPHATASE 15
P00010	B cell activation	P00381	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IGI	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00951	Jnk	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00021	FGF signaling pathway	P00632	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00474	Wnt	MONDO|Ensembl=ENSMODG00000015792|UniProtKB=Q2QL96	Protein Wnt-2	ISS	8717036	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00021	FGF signaling pathway	P00627	ERK1-2	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00048	PI3 kinase pathway	P01192	p110	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02777	Succinate to proprionate conversion	P03163	Methylmalonyl-CoA decarboxylase	THEKO|EnsemblGenome=TK1622|UniProtKB=Q5JIS8	Methylmalonyl-CoA decarboxylase, alpha subunit	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	1764995	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	IDA	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00021	FGF signaling pathway	P00644	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IGI	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00053	T cell activation	P01316	MHC-antigen	BOVIN|Ensembl=ENSBTAG00000009656|UniProtKB=E1BLZ1	Uncharacterized protein	IPI	73139	PubMed	PTHR19944:SF59	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DQ ALPHA 1 CHAIN
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00005	Angiogenesis	P00206	Wnt	MOUSE|MGI=MGI=108071|UniProtKB=P70701	Protein Wnt-10a	ISS	11266476	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	RAT|RGD=621544|UniProtKB=P12391	Neuronal acetylcholine receptor subunit beta-3	ISS			PTHR18945:SF75	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000002775|UniProtKB=H2RB55	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00018	EGF receptor signaling pathway	P00558	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05916	Opioid prodynorphin pathway	P06002	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00010	B cell activation	P00402	Jnk	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00053	T cell activation	P01331	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IDA	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04392	P53 pathway feedback loops 1	P04539	p53	CHICK|Ensembl=ENSGALG00000007324|UniProtKB=F1N8Z7	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00005	Angiogenesis	P00243	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	G01575	GADD45	PANTR|Ensembl=ENSPTRG00000000842|UniProtKB=H2R902	Growth arrest and DNA-damage-inducible, alpha	ISS	10097101	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000011757|UniProtKB=Q9XT97	Presenilin-1	TAS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P05916	Opioid prodynorphin pathway	P06002	G-protein	XENTR|Xenbase=XB-GENE-977853|UniProtKB=F7EBE7	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00030	Hypoxia response via HIF activation	P00819	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00010	B cell activation	P00376	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000000223|UniProtKB=F6XHK8	Uncharacterized protein	ISS	11701344	PubMed	PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P00010	B cell activation	P00402	Jnk	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04397	p53 pathway by glucose deprivation	P04641	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00925	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	ISS	14765990	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2343|UniProtKB=P08483	Muscarinic acetylcholine receptor M3	IDA			PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00003	Alzheimer disease-amyloid secretase pathway	P00093	Tip60	CANLF|Ensembl=ENSCAFG00000010382|UniProtKB=F1PP27	Uncharacterized protein	ISS			PTHR12345:SF12	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 2
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	CHICK|Ensembl=ENSGALG00000011875|UniProtKB=F1NJJ8	Uncharacterized protein	ISS	11055438	PubMed	PTHR10117:SF8	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 3
P05915	Opioid proenkephalin pathway	P05994	G-protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00556	PLCgamma	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00022	General transcription by RNA polymerase I	P00656	PTRF	PANTR|Ensembl=ENSPTRG00000040069|UniProtKB=H2RE35	Uncharacterized protein	ISS	603198	OMIM	PTHR15240:SF3	POLYMERASE I AND TRANSCRIPT RELEASE FACTOR
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00053	T cell activation	P01320	PLC-gamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00029	Huntington disease	P00775	Rac	ORYSJ|EnsemblGenome=OS05G0513800|UniProtKB=Q68Y52	Rac-like GTP-binding protein 2	ISS			PTHR24072:SF127	RAC-LIKE GTP-BINDING PROTEIN ARAC7
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00021	FGF signaling pathway	P00644	p38	CAEEL|WormBase=WBGene00004056|UniProtKB=Q8MXI4	Mitogen-activated protein kinase pmk-2	ISS	10851062	PubMed	PTHR24055:SF154	MITOGEN-ACTIVATED PROTEIN KINASE PMK-2
P00029	Huntington disease	P00775	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	20264070	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00005	Angiogenesis	P00223	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05752	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	HUMAN|HGNC=2191|UniProtKB=Q05707	Collagen alpha-1(XIV) chain	IC	10778855	PubMed	PTHR44557:SF1	COLLAGEN ALPHA-1 XIV  CHAIN
P00005	Angiogenesis	P00206	Wnt	MOUSE|MGI=MGI=98954|UniProtKB=P21552	Protein Wnt-2	ISS	11266476	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00048	PI3 kinase pathway	P01206	14-3-3	CANLF|Ensembl=ENSCAFG00000000580|UniProtKB=F1PBL1	Uncharacterized protein	ISS	92283271	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	3755548	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00047	PDGF signaling pathway	P01159	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00047	PDGF signaling pathway	P01151	PKB	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00859	NFkappaB	RAT|RGD=70498|UniProtKB=Q63369	Nuclear factor NF-kappa-B p105 subunit (Fragment)	ISS	8598461	PubMed	PTHR24169:SF9	NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT
P00010	B cell activation	P00388	PLC gamma2	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PANTR|Ensembl=ENSPTRG00000006175|UniProtKB=H2R2N7	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF721	MYOSIN-6
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	PANTR|Ensembl=ENSPTRG00000017278|UniProtKB=H2QRJ8	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	HUMAN|HGNC=1736|UniProtKB=P60953	Cell division control protein 42 homolog	IDA	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00023	General transcription regulation	P00661	TTF2	HUMAN|HGNC=30779|UniProtKB=Q49AM1	Transcription termination factor 2, mitochondrial	ISS	604718	OMIM	PTHR15437:SF1	TRANSCRIPTION TERMINATION FACTOR 2, MITOCHONDRIAL
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=4594|UniProtKB=Q14416	Metabotropic glutamate receptor 2	IDA	12488551	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P05731	GABA-B receptor II signaling	P05752	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00023	General transcription regulation	P00662	TFIIA complex	SCHPO|PomBase=SPCC553.11c|UniProtKB=O74948	Transcription initiation factor IIA subunit 2	ISS			PTHR10966:SF0	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2
P00036	Interleukin signaling pathway	P00964	p90RSK	CANLF|Ensembl=ENSCAFG00000013171|UniProtKB=E2RP04	Uncharacterized protein	ISS	6755374	gi	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00036	Interleukin signaling pathway	P00964	p90RSK	HUMAN|HGNC=10431|UniProtKB=Q15349	Ribosomal protein S6 kinase alpha-2	IC	6755374	gi	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P02741	Flavin biosynthesis	P02940	Riboflavin synthase	ARATH|TAIR=AT2G20690|UniProtKB=Q9SKU8	At2g20690/F5H14.34	ISS			PTHR21098:SF0	RIBOFLAVIN SYNTHASE
P04398	p53 pathway feedback loops 2	P04651	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00020	FAS signaling pathway	P00594	Caspase8	HUMAN|HGNC=1876|UniProtKB=O15519	CASP8 and FADD-like apoptosis regulator	IGI	8681376	PubMed	PTHR10454:SF8	CASP8 AND FADD-LIKE APOPTOSIS REGULATOR
P00053	T cell activation	P01311	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00021	FGF signaling pathway	P00627	ERK1-2	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IGI	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01429	Axin	RAT|RGD=620859|UniProtKB=O70239	Axin-1	IDA	9554852	PubMed	PTHR10845:SF11	AXIN-1
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	PYRAE|EnsemblGenome=PAE2556|UniProtKB=Q8ZUY0	Glutamine synthetase	ISS			PTHR43785:SF1	TYPE-1 GLUTAMINE SYNTHETASE 2
P00017	DNA replication	P00535	5' to 3' Exoribonulcease	MOUSE|MGI=MGI=891964|UniProtKB=P97789	5'-3' exoribonuclease 1	ISS	97201457	PubMed	PTHR12341:SF7	5'-3' EXORIBONUCLEASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	HUMAN|HGNC=1389|UniProtKB=Q00975	Voltage-dependent N-type calcium channel subunit alpha-1B	IDA	14507926	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00048	PI3 kinase pathway	P01192	p110	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00025	Hedgehog signaling pathway	P00690	Cubitus interruptus	HUMAN|HGNC=4319|UniProtKB=P10071	Transcriptional activator GLI3	IDA	15994174	PubMed	PTHR19818:SF5	TRANSCRIPTIONAL ACTIVATOR GLI3
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	IDA	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00034	Integrin signalling pathway	P00941	Integrin alpha	PANTR|Ensembl=ENSPTRG00000005059|UniProtKB=H2Q659	Uncharacterized protein	ISS	3487386	PubMed	PTHR23220:SF90	INTEGRIN ALPHA-7
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	XENTR|Xenbase=XB-GENE-494200|UniProtKB=F7CS79	Uncharacterized protein	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00018	EGF receptor signaling pathway	P00551	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IGI	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=12776|UniProtKB=O96014	Protein Wnt-11	TAS	8717036	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00046	Oxidative stress response	P01135	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01162	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	IDA	10851062	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00019	Endothelin signaling pathway	P00577	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IGI	1171954	gi	PTHR10048:SF14	PI-3 KINASE
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	PHYPA|Gene=PHYPADRAFT_121533|UniProtKB=A9RYX6	Predicted protein	ISS			PTHR23073:SF8	26S PROTEASE REGULATORY SUBUNIT 6B
P00010	B cell activation	P00391	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00048	PI3 kinase pathway	P01202	p85	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ORYSJ|Gene=Os01g0866100|UniProtKB=P0C540	Actin-7	IC	11889126	PubMed	PTHR11937:SF205	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CANLF|Ensembl=ENSCAFG00000009203|UniProtKB=F1PVZ1	Muscarinic acetylcholine receptor	ISS	12181435	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=1756|UniProtKB=Q12864	Cadherin-17	IDA	8120095	PubMed	PTHR44603:SF2	CADHERIN-17
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	ISS	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00627	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10557357	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00010	B cell activation	P00375	Calmodulin	MACMU|Ensembl=ENSMMUG00000028962|UniProtKB=F7EWG5	Uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF322	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01414	PLC-gamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00049	Parkinson disease	P01211	ERK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	IDA	10851062	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P05730	Endogenous cannabinoid signaling	P05746	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IC	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00025	Hedgehog signaling pathway	P00683	Slimb	ORNAN|Ensembl=ENSOANG00000007791|UniProtKB=F6YUQ2	Uncharacterized protein	ISS	10074433	PubMed	PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	10074940	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02738	De novo purine biosynthesis	P02891	GDP kinase	CANLF|Ensembl=ENSCAFG00000030883|UniProtKB=J9NSB4	Nucleoside diphosphate kinase	ISS			PTHR11349:SF70	NUCLEOSIDE DIPHOSPHATE KINASE 6
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04568	MKK3/6	ORNAN|Ensembl=ENSOANG00000007732|UniProtKB=F6PXH5	Uncharacterized protein (Fragment)	ISS	11971971	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04393	Ras Pathway	P04542	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00021	FGF signaling pathway	P00623	FGF	BOVIN|Ensembl=ENSBTAG00000001530|UniProtKB=F1N6G8	Fibroblast growth factor	ISS	12778074	PubMed	PTHR11486:SF3	FIBROBLAST GROWTH FACTOR 8
P00019	Endothelin signaling pathway	P00587	Raf-1	TAKRU|Ensembl=ENSTRUG00000006611|UniProtKB=H2SV11	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	CHICK|Gene=KCNJ3|UniProtKB=Q90854	G protein-activated inward rectifier potassium channel 1	IDA	12374786	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	TAS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00780	Microtubule	LEIMA|EnsemblGenome=LmjF.21.1860|UniProtKB=Q4QBZ6	Beta tubulin	IDA	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	PANTR|Ensembl=ENSPTRG00000008283|UniProtKB=H2QBF3	Uncharacterized protein	ISS			PTHR12533:SF10	NUCLEAR FACTOR OF ACTIVATED T-CELLS 5
P00034	Integrin signalling pathway	P00907	ERK	MONDO|Ensembl=ENSMODG00000004896|UniProtKB=F7C2C6	Uncharacterized protein (Fragment)	ISS	8444355	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MACMU|Ensembl=ENSMMUG00000018206|UniProtKB=F7E951	Matrix metalloproteinase-24	ISS	12834808	PubMed	PTHR10201:SF138	MATRIX METALLOPROTEINASE-24
P00010	B cell activation	P00381	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01310	Lck	BOVIN|Ensembl=ENSBTAG00000012695|UniProtKB=Q3ZCM0	Tyrosine-protein kinase	ISS	1505025	PubMed	PTHR24418:SF39	TYROSINE-PROTEIN KINASE LCK
P00010	B cell activation	P00385	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	15470041	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05730	Endogenous cannabinoid signaling	P05746	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00108	ADAM10	PANTR|Ensembl=ENSPTRG00000007116|UniProtKB=H2Q9I4	ADAM metallopeptidase domain 10	ISS	10097139	PubMed	PTHR11905:SF4	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 10
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IDA	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00578	eNOS	CANLF|Gene=NOS3|UniProtKB=Q9TUX8	Nitric oxide synthase, endothelial	ISS	10435050	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00048	PI3 kinase pathway	P01192	p110	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00546	GAP	HUMAN|HGNC=9871|UniProtKB=P20936	Ras GTPase-activating protein 1	IGI	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00059	p53 pathway	P04632	SIRT-1	HUMAN|HGNC=14929|UniProtKB=Q96EB6	NAD-dependent protein deacetylase sirtuin-1	IDA	12006491	PubMed	PTHR11085:SF15	NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1
P04398	p53 pathway feedback loops 2	G04714	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00037	Ionotropic glutamate receptor pathway	P01001	KA4	MACMU|Ensembl=ENSMMUG00000022347|UniProtKB=F6ZCH5	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	89186920	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P02757	O-antigen biosynthesis	P03050	dTDP-4-dehydrorhamnose reductase	CANLF|Ensembl=ENSCAFG00000017181|UniProtKB=E2RT47	Uncharacterized protein	ISS			PTHR10491:SF4	METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	MOUSE|MGI=MGI=96648|UniProtKB=P15066	Transcription factor jun-D	ISS	10664585	PubMed	PTHR11462:SF7	TRANSCRIPTION FACTOR JUN-D
P04397	p53 pathway by glucose deprivation	P04639	AMPK	MOUSE|MGI=MGI=1336167|UniProtKB=Q9R078	5'-AMP-activated protein kinase subunit beta-1	ISS			PTHR10343:SF16	5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1
P00056	VEGF signaling pathway	P01413	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	129387	gi	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	IGI	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ARATH|TAIR=AT2G32730|UniProtKB=O48844	26S proteasome non-ATPase regulatory subunit 1 homolog A	ISS			PTHR10943:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1
P00053	T cell activation	P01330	IKK	HUMAN|HGNC=5960|UniProtKB=O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	IGI	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00021	FGF signaling pathway	P00632	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04657	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02751	Lysine biosynthesis	P03007	Diaminopimelate decarboxylase	STRCO|EnsemblGenome=CAA22747|UniProtKB=Q9ZBH5	Diaminopimelate decarboxylase	ISS			PTHR43727:SF2	DIAMINOPIMELATE DECARBOXYLASE 1, CHLOROPLASTIC-RELATED
P00048	PI3 kinase pathway	P01190	PDK1 ACT	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00019	Endothelin signaling pathway	P00590	IP3 R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P02787	Vitamin B6 metabolism	P03227	Phosphoserine transaminase	RAT|RGD=735170|UniProtKB=A0A0G2K931	Phosphoserine aminotransferase	TAS	20886743	gi	PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P00015	Circadian clock system	G01499	per	MOUSE|MGI=MGI=1195265|UniProtKB=O54943	Period circadian protein homolog 2	ISS			PTHR11269:SF9	PERIOD CIRCADIAN PROTEIN HOMOLOG 2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IDA	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04393	Ras Pathway	P04556	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02772	Pyruvate metabolism	P03137	Citrate Lyase	HALSA|EnsemblGenome=VNG_0627G|UniProtKB=Q9HRM8	Citrate (Pro-3S)-lyase	ISS			PTHR32308:SF0	CITRATE LYASE SUBUNIT BETA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P02738	De novo purine biosynthesis	P02891	GDP kinase	HUMAN|HGNC=7853|UniProtKB=P56597	Nucleoside diphosphate kinase homolog 5	ISS			PTHR11349:SF64	NUCLEOSIDE DIPHOSPHATE KINASE HOMOLOG 5
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	ARATH|TAIR=AT3G23340|UniProtKB=Q9LW62	AT3g23340/MLM24_21	IDA	10617630	PubMed	PTHR11909:SF178	CASEIN KINASE 1-LIKE PROTEIN 8
P00021	FGF signaling pathway	P00645	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P02726	Aminobutyrate degradation	P02825	4-aminobutyrate aminotransferase	HUMAN|HGNC=23|UniProtKB=P80404	4-aminobutyrate aminotransferase, mitochondrial	ISS	10989446	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	SCHPO|PomBase=SPBC36.04|UniProtKB=O59701	Cysteine synthase 1	ISS			PTHR10314:SF159	CYSTEINE SYNTHASE A
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DICDI|dictyBase=DDB_G0274383|UniProtKB=Q8MLZ3	cGMP-dependent 3',5'-cGMP phosphodiesterase A	IC	2372396	PubMed	PTHR45452:SF1	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	RAT|RGD=619751|UniProtKB=O88302	Guanine nucleotide-binding protein subunit alpha-15	ISS	11534853	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8691|UniProtKB=Q9Y5E3	Protocadherin beta-6	IDA	8120095	PubMed	PTHR24028:SF104	PROTOCADHERIN BETA-6
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00034	Integrin signalling pathway	P00935	ILK	CANLF|Ensembl=ENSCAFG00000006488|UniProtKB=E2R5H4	Uncharacterized protein	ISS			PTHR44344:SF1	INTEGRIN-LINKED PROTEIN KINASE
P00025	Hedgehog signaling pathway	P00686	Fused	PANTR|Ensembl=ENSPTRG00000012926|UniProtKB=H2QJF4	Uncharacterized protein	ISS			PTHR22983:SF6	SERINE/THREONINE-PROTEIN KINASE 36
P05916	Opioid prodynorphin pathway	P06002	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P02749	Leucine biosynthesis	P03002	Isopropylmalate isomerase	STRCO|EnsemblGenome=CAA20002|UniProtKB=O86535	3-isopropylmalate dehydratase small subunit	ISS			PTHR43345:SF2	3-ISOPROPYLMALATE DEHYDRATASE SMALL SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CAEEL|WormBase=WBGene00006454|UniProtKB=G5EEN8	AEX-4	IC			PTHR19305:SF10	AEX-4
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=12788|UniProtKB=Q9H1J5	Protein Wnt-8a	IDA	11266476	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02768	Proline biosynthesis	P03114	Glutamyl kinase	DEIRA|EnsemblGenome=DR_1827|UniProtKB=Q9RTD8	Glutamate 5-kinase	ISS			PTHR43654:SF3	GLUTAMATE 5-KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04407	K+ channel	MONDO|Ensembl=ENSMODG00000015769|UniProtKB=F6ZSC2	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P04395	Vasopressin synthesis	P04589	Signal Peptidase	PANTR|Ensembl=ENSPTRG00000016615|UniProtKB=H2QQG6	Uncharacterized protein	ISS	2092035	PubMed	PTHR12804:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 3
P00021	FGF signaling pathway	P00642	MEK1-2	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	HUMAN|HGNC=4571|UniProtKB=P42261	Glutamate receptor 1	ISS	12871085	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00053	T cell activation	P01331	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	DAPPU|EnsemblGenome=DAPPUDRAFT_194510|UniProtKB=E9G7U7	Serine/threonine-protein phosphatase (Fragment)	ISS	8392016	PubMed	PTHR11668:SF282	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-BETA CATALYTIC SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00141	Membrane metalloprotease	PANTR|Ensembl=ENSPTRG00000008173|UniProtKB=H2QB81	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF25	MATRIX METALLOPROTEINASE-15
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	DAPPU|EnsemblGenome=DAPPUDRAFT_304965|UniProtKB=E9GMZ1	Putative uncharacterized protein	ISS			PTHR12458:SF8	CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20
P00057	Wnt signaling pathway	P01429	Axin	HUMAN|HGNC=903|UniProtKB=O15169	Axin-1	IDA	9554852	PubMed	PTHR10845:SF11	AXIN-1
P00018	EGF receptor signaling pathway	P00554	Shc	MOUSE|MGI=MGI=106179|UniProtKB=Q61120	SHC-transforming protein 3	IGI	8610109	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00053	T cell activation	P01307	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00038	JAK/STAT signaling pathway	P01027	STAT	RAT|RGD=3774|UniProtKB=P52632	Signal transducer and activator of transcription 5B	ISS	8584036	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00047	PDGF signaling pathway	P01165	SRF	PANTR|Ensembl=ENSPTRG00000018189|UniProtKB=H2QT21	Uncharacterized protein	ISS	15170389	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	ARATH|TAIR=AT2G21330|UniProtKB=Q9SJU4	Probable fructose-bisphosphate aldolase 1, chloroplastic	TAS	18420348	gi	PTHR11627:SF22	FRUCTOSE-BISPHOSPHATE ALDOLASE 1, CHLOROPLASTIC-RELATED
P00010	B cell activation	P00369	MEKK	MACMU|Ensembl=ENSMMUG00000018568|UniProtKB=F6YLW2	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00053	T cell activation	P01332	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00973	PKB	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	HUMAN|HGNC=145|UniProtKB=P63267	Actin, gamma-enteric smooth muscle	IC	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00018	EGF receptor signaling pathway	P00561	STAT	BOVIN|Gene=STAT5A|UniProtKB=Q95115	Signal transducer and activator of transcription 5A	ISS	8584036	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02927	Dihydrooratate oxidase	AQUAE|EnsemblGenome=aq_046|UniProtKB=O66461	Putative dihydroorotate dehydrogenase A (fumarate)	ISS			PTHR43843:SF1	DIHYDROOROTATE DEHYDROGENASE  FUMARATE
P04393	Ras Pathway	P04546	GSK3	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	IDA	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00049	Parkinson disease	P01235	Fyn kinase	BOVIN|Ensembl=ENSBTAG00000011851|UniProtKB=A0JNB0	Tyrosine-protein kinase Fyn	ISS	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00019	Endothelin signaling pathway	P00589	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IGI	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02752	Mannose metabolism	P03018	Mannose 1-P guanylyl transferase	ARATH|TAIR=AT4G30570|UniProtKB=Q8H1Q7	Probable mannose-1-phosphate guanylyltransferase 3	ISS	7269958	gi	PTHR22572:SF15	MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE BETA
P02738	De novo purine biosynthesis	P02907	dADP kinase	PANTR|Ensembl=ENSPTRG00000014882|UniProtKB=H2QMI8	Nucleoside diphosphate kinase	ISS			PTHR11349:SF70	NUCLEOSIDE DIPHOSPHATE KINASE 6
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MOUSE|MGI=MGI=1270849|UniProtKB=Q8BSK8	Ribosomal protein S6 kinase beta-1	ISS	15116068	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DICDI|dictyBase=DDB_G0289489|UniProtKB=P07828	Actin-18	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00036	Interleukin signaling pathway	P00987	SRF	HUMAN|HGNC=11291|UniProtKB=P11831	Serum response factor	IC	15170389	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P06959	CCKR signaling map	P07161	PDE	HUMAN|HGNC=8774|UniProtKB=P54750	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	RCA	17307970	PubMed	PTHR11347:SF34	CALCIUM/CALMODULIN-DEPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1A
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00010	B cell activation	P00402	Jnk	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	RAT|RGD=1306522|UniProtKB=Q4L0E8	Regulator of G-protein signaling 18	ISS	8756726	PubMed	PTHR10845:SF155	REGULATOR OF G-PROTEIN SIGNALING 18
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	XENTR|Xenbase=XB-GENE-490883|UniProtKB=Q6NVA9	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00053	T cell activation	P01300	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00775	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00052	TGF-beta signaling pathway	P01275	P38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00006	Apoptosis signaling pathway	P00286	AIF	MACMU|Ensembl=ENSMMUG00000004954|UniProtKB=F7C7I3	Apoptosis-inducing factor 1, mitochondrial	ISS	9989411	PubMed	PTHR43557:SF4	APOPTOSIS-INDUCING FACTOR 1, MITOCHONDRIAL
P00004	Alzheimer disease-presenilin pathway	P00168	E-cadherin intracellular fragment	MOUSE|MGI=MGI=88356|UniProtKB=P10287	Cadherin-3	IDA	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF330	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00778	NMDA receptor	HUMAN|HGNC=4584|UniProtKB=Q05586	Glutamate receptor ionotropic, NMDA 1	IDA	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00021	FGF signaling pathway	P00624	14-3-3	DAPPU|EnsemblGenome=DAPPUDRAFT_326737|UniProtKB=E9H8M4	Putative uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IC	3045562	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00557	PI3K	CAEEL|WormBase=WBGene00006932|UniProtKB=Q9TXI7	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00053	T cell activation	P01311	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00017	DNA replication	P00535	5' to 3' Exoribonulcease	RAT|RGD=1310218|UniProtKB=D4A914	5'-3' exoribonuclease 2 (Predicted), isoform CRA_a	ISS	99339991	PubMed	PTHR12341:SF41	5'-3' EXORIBONUCLEASE 2
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	MOUSE|MGI=MGI=1351345|UniProtKB=P47743	Metabotropic glutamate receptor 8	IC	12351712	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	RAT|RGD=69250|UniProtKB=Q9QXQ7	Protein Wnt-5a	TAS	8717036	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00047	PDGF signaling pathway	P01154	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00023	General transcription regulation	P00658	TBP-associated factors	CHICK|Ensembl=ENSGALG00000003498|UniProtKB=Q5ZMS1	Transcription initiation factor TFIID subunit 8	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	TAS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000016761|UniProtKB=H2R1Q6	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF322	CADHERIN-6
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Gene=PCDHB9|UniProtKB=Q5DRC4	Protocadherin beta-9	ISS	8120095	PubMed	PTHR24028:SF128	PROTOCADHERIN BETA-9
P00005	Angiogenesis	P00241	VEGF	DANRE|ZFIN=ZDB-GENE-990415-273|UniProtKB=O73682	Vascular endothelial growth factor A-A	ISS			PTHR12025:SF14	VASCULAR ENDOTHELIAL GROWTH FACTOR A-A
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CHICK|Ensembl=ENSGALG00000009621|UniProtKB=P60706	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	DROME|FlyBase=FBgn0000617|UniProtKB=Q27272	Transcription initiation factor TFIID subunit 9	ISS			PTHR12595:SF6	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 9
P00034	Integrin signalling pathway	P00925	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IDA	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	MONDO|Ensembl=ENSMODG00000014177|UniProtKB=F6U7A6	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	PANTR|Ensembl=ENSPTRG00000040283|UniProtKB=H2RII6	Suppressor of cytokine signaling 5	ISS	15032587	PubMed	PTHR44282:SF3	SUPPRESSOR OF CYTOKINE SIGNALING 5
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	XENTR|Xenbase=XB-GENE-6050844|UniProtKB=F6WNJ9	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00048	PI3 kinase pathway	P01185	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	CHICK|Ensembl=ENSGALG00000010812|UniProtKB=F1NLZ9	Uncharacterized protein	ISS	8930069	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05913	Enkephalin release	P05977	G-Protein (s)	MACMU|Ensembl=ENSMMUG00000010266|UniProtKB=F6PV18	Uncharacterized protein	ISS	6309844	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P04393	Ras Pathway	P04567	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01095	beta	MACMU|Ensembl=ENSMMUG00000016089|UniProtKB=F7GMZ4	Neuronal acetylcholine receptor subunit beta-2	ISS	15155845	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	HUMAN|HGNC=3828|UniProtKB=P25089	N-formyl peptide receptor 3	IC			PTHR24225:SF16	N-FORMYL PEPTIDE RECEPTOR 3
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00005	Angiogenesis	P00206	Wnt	CANLF|Ensembl=ENSCAFG00000029321|UniProtKB=J9P5H0	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	MONDO|Ensembl=ENSMODG00000015693|UniProtKB=F7E0R2	Uncharacterized protein	ISS			PTHR11405:SF5	CAD PROTEIN
P00049	Parkinson disease	P01211	ERK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01174	Rho	MACMU|Ensembl=ENSMMUG00000004778|UniProtKB=F6SEZ7	Rho GTPase-activating protein 12	ISS			PTHR23181:SF3	RHO GTPASE-ACTIVATING PROTEIN 12
P00055	Transcription regulation by bZIP transcription factor	P01392	TFIIH complex	YEAST|SGD=S000006260|UniProtKB=Q12004	RNA polymerase II transcription factor B subunit 4	ISS			PTHR12831:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	TAKRU|Ensembl=ENSTRUG00000000304|UniProtKB=H2RKM1	Uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00056	VEGF signaling pathway	P01414	PLC-gamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00029	Huntington disease	P00774	Dynein complex	RAT|RGD=620174|UniProtKB=Q62871	Cytoplasmic dynein 1 intermediate chain 2	IPI	9454836	PubMed	PTHR12442:SF22	CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P02783	Tryptophan biosynthesis	P03206	Anthranilate synthase	BACSU|EnsemblGenome=BSU00750|UniProtKB=P28819	Aminodeoxychorismate/anthranilate synthase component 2	RCA			PTHR43418:SF4	MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00057	Wnt signaling pathway	P01465	Ggamma	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00047	PDGF signaling pathway	P01173	STAT	MACMU|Ensembl=ENSMMUG00000017527|UniProtKB=F6UMM2	Signal transducer and activator of transcription	ISS	8085155	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00048	PI3 kinase pathway	P01202	p85	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P05730	Endogenous cannabinoid signaling	P05746	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00012	Cadherin signaling pathway	P00474	Wnt	TAKRU|Ensembl=ENSTRUG00000011280|UniProtKB=H2TUW3	Protein Wnt	IDA	8717036	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00036	Interleukin signaling pathway	P00990	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01190	PDK1 ACT	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CHICK|Ensembl=ENSGALG00000012894|UniProtKB=P30372	Muscarinic acetylcholine receptor M2	IDA	10069496	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P02771	Pyrimidine Metabolism	P03127	Beta-Ureidopropionase	CANLF|Ensembl=ENSCAFG00000013843|UniProtKB=J9P8R1	Uncharacterized protein	ISS	10542323	PubMed	PTHR43674:SF2	BETA-UREIDOPROPIONASE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	DANRE|ZFIN=ZDB-GENE-030219-1|UniProtKB=F1QX69	Uncharacterized protein (Fragment)	ISS	9759503	PubMed	PTHR11848:SF164	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ARATH|TAIR=AT2G42880|UniProtKB=Q9SJG9	Mitogen-activated protein kinase 20	IDA	176948	OMIM	PTHR24055:SF158	MITOGEN-ACTIVATED PROTEIN KINASE 20
P00018	EGF receptor signaling pathway	P00562	p38	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	MACMU|Ensembl=ENSMMUG00000010173|UniProtKB=F7AGU8	Presenilin	ISS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01444	Wnt	PANTR|Ensembl=ENSPTRG00000004893|UniProtKB=H2Q5U4	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02738	De novo purine biosynthesis	P02905	Amidophosphoribosyl transferase	MOUSE|MGI=MGI=2387203|UniProtKB=Q8CIH9	Amidophosphoribosyltransferase	ISS			PTHR11907:SF18	AMIDOPHOSPHORIBOSYLTRANSFERASE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05731	GABA-B receptor II signaling	P05752	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	TAS	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00543	ERK1-2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	CANLF|Ensembl=ENSCAFG00000008653|UniProtKB=F1PE26	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MACMU|Ensembl=ENSMMUG00000020532|UniProtKB=F7D8E6	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF98	RIBOSOMAL PROTEIN S6 KINASE ALPHA-6
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=3972|UniProtKB=Q12841	Follistatin-related protein 1	ISS	11266476	PubMed	PTHR10913:SF13	FOLLISTATIN-RELATED PROTEIN 1
P00059	p53 pathway	P04609	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05913	Enkephalin release	P05972	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00985	PDK1/2	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	ISS	15531926	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00053	T cell activation	P01336	Jnk	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00552	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P02741	Flavin biosynthesis	P02934	Riboflavin kinase	FUSNN|EnsemblGenome=FN0707|UniProtKB=Q8RFI9	Riboflavin biosynthesis protein	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P00006	Apoptosis signaling pathway	P00311	GCKR	CANLF|Ensembl=ENSCAFG00000006426|UniProtKB=F1PZN1	Mitogen-activated protein kinase kinase kinase kinase	ISS			PTHR24361:SF205	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 3
P00021	FGF signaling pathway	P00633	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00047	PDGF signaling pathway	P01145	c-fos	PANTR|Ensembl=ENSPTRG00000006553|UniProtKB=A5A6H0	C-fos	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00029	Huntington disease	P00771	Sin3A	ARATH|TAIR=AT1G70060|UniProtKB=O04539	Paired amphipathic helix protein Sin3-like 4	IDA	10441327	PubMed	PTHR12346:SF0	SIN3A, ISOFORM G
P00009	Axon guidance mediated by netrin	P00360	DCC/UNC-40	MACMU|Ensembl=ENSMMUG00000013999|UniProtKB=F6RRI0	Uncharacterized protein	ISS	8861902	PubMed	PTHR44146:SF3	NETRIN RECEPTOR DCC
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	ORNAN|Ensembl=ENSOANG00000004058|UniProtKB=F6TYP9	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00047	PDGF signaling pathway	P01153	GSK3	NEUCR|EnsemblGenome=EFNCRG00000003957|UniProtKB=V5ILY7	Protein kinase gsk3	ISS	21361340	gi	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DANRE|ZFIN=ZDB-GENE-030131-172|UniProtKB=Q6IQR3	Actin, alpha, cardiac muscle 1a	IC	11889139	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00036	Interleukin signaling pathway	P00970	Interleukin	HUMAN|HGNC=6025|UniProtKB=P10145	Interleukin-8	IC	124361	gi	PTHR10179:SF70	INTERLEUKIN-8
P00005	Angiogenesis	P00182	p38MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P06664	Gonadotropin-releasing hormone receptor pathway	G06677	Junc	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	RCA	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00005	Angiogenesis	P00224	PDGF	PANTR|Ensembl=ENSPTRG00000004227|UniProtKB=H2Q4N6	Platelet derived growth factor D	ISS	12629513	PubMed	PTHR11633:SF4	PLATELET-DERIVED GROWTH FACTOR D
P04393	Ras Pathway	P04572	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	MOUSE|MGI=MGI=109521|UniProtKB=P35363	5-hydroxytryptamine receptor 2A	ISS	12181435	PubMed	PTHR24247:SF30	5-HYDROXYTRYPTAMINE RECEPTOR 2A
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	BOVIN|Ensembl=ENSBTAG00000015580|UniProtKB=F1ML22	Uncharacterized protein	ISS	9783586	PubMed	PTHR10814:SF24	TRANSDUCIN-LIKE ENHANCER PROTEIN 3
P00037	Ionotropic glutamate receptor pathway	P01001	KA4	HUMAN|HGNC=4582|UniProtKB=Q16099	Glutamate receptor ionotropic, kainate 4	IC	11319238	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00036	Interleukin signaling pathway	P00996	STAT	MACMU|Ensembl=ENSMMUG00000010705|UniProtKB=F7G8V4	Signal transducer and activator of transcription	ISS	14662325	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00056	VEGF signaling pathway	P01413	PI3K	ANOGA|Gene=AgaP_AGAP010273|UniProtKB=Q7PMF0	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05913	Enkephalin release	P05978	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=98961|UniProtKB=P24383	Protein Wnt-7a	IDA	8717036	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00049	Parkinson disease	P01224	UbcH7	HUMAN|HGNC=12488|UniProtKB=P68036	Ubiquitin-conjugating enzyme E2 L3	RCA			PTHR24068:SF67	UBIQUITIN-CONJUGATING ENZYME E2 L3
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-010705-1|UniProtKB=Q90Z40	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P02763	Peptidoglycan biosynthesis	P03091	D-alanine-D-alanine ligase	STRCO|EnsemblGenome=CAA22403|UniProtKB=Q9ZBR9	D-alanine--D-alanine ligase	ISS			PTHR23132:SF8	D-ALANINE--D-ALANINE LIGASE A
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000021808|UniProtKB=Q9MZL3	Voltage-dependent L-type calcium channel subunit beta-3	IC			PTHR11824:SF8	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	XENTR|GeneID=394982|UniProtKB=P20399	Actin, alpha cardiac muscle 2	ISS	11889126	PubMed	PTHR11937:SF263	ACTIN
P00018	EGF receptor signaling pathway	G01511	SPRY	CANLF|Ensembl=ENSCAFG00000005260|UniProtKB=E2RGU9	Uncharacterized protein	ISS	12402043	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=14674|UniProtKB=Q96QU1	Protocadherin-15	IDA	8120095	PubMed	PTHR24028:SF11	PROTOCADHERIN-15
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00010	B cell activation	P00384	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01443	Phospholipase C	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00021	FGF signaling pathway	P00644	p38	CAEBR|Gene=CBG01555|UniProtKB=A8WRD7	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00029	Huntington disease	P00807	Actin	RAT|RGD=2025|UniProtKB=P68136	Actin, alpha skeletal muscle	ISS	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00021	FGF signaling pathway	P00642	MEK1-2	CAEEL|WormBase=WBGene00003186|UniProtKB=Q10664	Dual specificity mitogen-activated protein kinase kinase mek-2	IGI	12024031	PubMed	PTHR24361:SF629	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	TAKRU|Ensembl=ENSTRUG00000011297|UniProtKB=H2TV18	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00050	Plasminogen activating cascade	P01250	MMP-13	BOVIN|Gene=MMP13|UniProtKB=O77656	Collagenase 3	ISS	Fang,Y.,Kitchell,B.E.,Paria,B.andBalkin,R.	free text	PTHR10201:SF165	COLLAGENASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Ensembl=ENSCAFG00000010787|UniProtKB=E2R3W6	Uncharacterized protein	ISS	11248120	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00057	Wnt signaling pathway	P01435	SWI/SNF	BOVIN|Ensembl=ENSBTAG00000003843|UniProtKB=Q9TTA5	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1	IDA	11532957	PubMed	PTHR10799:SF731	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A-LIKE PROTEIN 1
P00052	TGF-beta signaling pathway	P01292	RSmads	PANTR|Ensembl=ENSPTRG00000016485|UniProtKB=H2QQ88	Mothers against decapentaplegic homolog	ISS	12736218	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P00005	Angiogenesis	P00210	eNOS	MACMU|Ensembl=ENSMMUG00000020437|UniProtKB=F6WEB2	Nitric oxide synthase	ISS	22462730	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00006	Apoptosis signaling pathway	P00301	Apaf-1	PANTR|Ensembl=ENSPTRG00000005335|UniProtKB=H2R1S6	Apoptotic protease-activating factor 1	ISS	10364241	PubMed	PTHR22845:SF5	APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
P00005	Angiogenesis	P00195	APC	RAT|RGD=2123|UniProtKB=P70478	Adenomatous polyposis coli protein	ISS	12549854	PubMed	PTHR12607:SF11	ADENOMATOUS POLYPOSIS COLI PROTEIN
P00018	EGF receptor signaling pathway	P00547	PP2A	RAT|RGD=6503701|UniProtKB=F1MAA3	Protein LOC100909464	ISS	96161994	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00019	Endothelin signaling pathway	P00573	signal peptidase	DROME|FlyBase=FBgn0262801|UniProtKB=O97066	Signal peptidase complex catalytic subunit SEC11	ISS	2092035	PubMed	PTHR10806:SF6	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11
P00019	Endothelin signaling pathway	P00586	Gq	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00035	Interferon-gamma signaling pathway	P00960	PTP	MONDO|Ensembl=ENSMODG00000003120|UniProtKB=F6WVD2	Tyrosine-protein phosphatase non-receptor type	ISS	14525967	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00057	Wnt signaling pathway	P01465	Ggamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	CANLF|Ensembl=ENSCAFG00000010255|UniProtKB=E2RPY4	Uncharacterized protein	ISS	12374786	PubMed	PTHR11767:SF52	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 4
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	RCA	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00019	Endothelin signaling pathway	P00573	signal peptidase	CHICK|Ensembl=ENSGALG00000002839|UniProtKB=F1NAZ9	Signal peptidase complex catalytic subunit SEC11	ISS	2092035	PubMed	PTHR10806:SF12	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11C
P00053	T cell activation	P01300	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MOUSE|MGI=MGI=2444552|UniProtKB=Q8BFZ3	Beta-actin-like protein 2	ISS	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=2136742|UniProtKB=Q91XZ2	MCG141292	IDA	8120095	PubMed	PTHR24028:SF100	MCG141292-RELATED
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00019	Endothelin signaling pathway	P00590	IP3 R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IGI	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	RAT|RGD=3784|UniProtKB=P61265	Syntaxin-1B	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	ORNAN|Ensembl=ENSOANG00000004058|UniProtKB=F6TYP9	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00022	General transcription by RNA polymerase I	P00652	RNA Polymerase I  Complex	CANLF|Ensembl=ENSCAFG00000018783|UniProtKB=E2QZE2	Uncharacterized protein	ISS			PTHR12790:SF0	RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN3-RELATED
P00057	Wnt signaling pathway	P01428	Frizzled	PANTR|Ensembl=ENSPTRG00000005632|UniProtKB=H2Q772	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF86	FRIZZLED-10
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P04376	5HT4 type receptor mediated signaling pathway	P04427	5HT4 Receptor	RAT|RGD=2850|UniProtKB=Q62758	5-hydroxytryptamine receptor 4	ISS	12898568	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P00048	PI3 kinase pathway	P01199	Galpha	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04557	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00552	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IGI	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P04393	Ras Pathway	P04570	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	YARLI|EnsemblGenome=YALI0_B11330g|UniProtKB=F2Z6G2	YALI0B11330p	ISS			PTHR11482:SF6	ORNITHINE DECARBOXYLASE 1-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	ANOGA|EnsemblGenome=AGAP000310|UniProtKB=Q7PRZ7	AGAP000310-PA	IC			PTHR24361:SF645	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P00053	T cell activation	P01311	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IDA	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00705	Gsalpha	MOUSE|MGI=MGI=95774|UniProtKB=Q8CGK7	Guanine nucleotide-binding protein G(olf) subunit alpha	ISS	6309844	PubMed	PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00464	Fyn	XENTR|Xenbase=XB-GENE-6053489|UniProtKB=F6S8L5	Tyrosine-protein kinase	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CANLF|Gene=GRIN1|UniProtKB=Q5R1P0	Glutamate receptor ionotropic, NMDA 1	IC	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00020	FAS signaling pathway	P00615	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MONDO|Ensembl=ENSMODG00000001933|UniProtKB=F6W0P2	Uncharacterized protein (Fragment)	ISS	12488551	PubMed	PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P00021	FGF signaling pathway	P00648	PKC	CANAL|CGD=CAL0003231|UniProtKB=Q5ANK2	Protein kinase C	IGI	125549	gi	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	DANRE|ZFIN=ZDB-GENE-000328-4|UniProtKB=B0S6S2	Uncharacterized protein	TAS	8717036	PubMed	PTHR11309:SF90	FRIZZLED-8
P00010	B cell activation	P00383	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00015	Circadian clock system	G01499	per	HUMAN|HGNC=8845|UniProtKB=O15534	Period circadian protein homolog 1	IDA	20570170	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	IGI	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	XENTR|Xenbase=XB-GENE-490836|UniProtKB=F7A011	Uncharacterized protein	ISS			PTHR11699:SF233	ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	MONDO|Ensembl=ENSMODG00000020352|UniProtKB=F7FKB2	Uncharacterized protein	ISS	96032356	PubMed	PTHR11958:SF24	EXCITATORY AMINO ACID TRANSPORTER 1
P00049	Parkinson disease	P01221	Torsin A	CAEEL|WormBase=WBGene00006597|UniProtKB=O45271	TORsin related	IDA	12421356	PubMed	PTHR10760:SF2	TORSIN-LIKE PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	HUMAN|HGNC=7881|UniProtKB=P46531	Neurogenic locus notch homolog protein 1	IDA	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	BOVIN|Ensembl=ENSBTAG00000007882|UniProtKB=G3X7Z2	Uncharacterized protein	IDA	14624853	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	TAKRU|Ensembl=ENSTRUG00000005608|UniProtKB=H2SM93	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00045	Notch signaling pathway	P01114	Ntm	BOVIN|Ensembl=ENSBTAG00000043971|UniProtKB=E1BPT8	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00005	Angiogenesis	P00221	JNK1	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00799	JNK-2	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00021	FGF signaling pathway	P00648	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	MONDO|Ensembl=ENSMODG00000010107|UniProtKB=F6X4I0	Clathrin heavy chain	ISS	9388255	PubMed	PTHR10292:SF6	CLATHRIN HEAVY CHAIN 2
P00056	VEGF signaling pathway	P01408	Akt/PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00709	Glycogen synthase D	BOVIN|Ensembl=ENSBTAG00000039958|UniProtKB=A7MB78	Glycogen [starch] synthase, muscle	ISS	4212312	PubMed	PTHR10176:SF2	GLYCOGEN  STARCH  SYNTHASE, MUSCLE
P00053	T cell activation	P01306	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P04393	Ras Pathway	P04578	Rho	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	IDA	12039949	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00056	VEGF signaling pathway	P01408	Akt/PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00022	General transcription by RNA polymerase I	P00650	TAF-IB	DROME|FlyBase=FBgn0022724|UniProtKB=Q9VWY6	Transcription initiation factor TFIID subunit 8	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	MACMU|Ensembl=ENSMMUG00000005656|UniProtKB=F6VXT4	Inosine-5'-monophosphate dehydrogenase	ISS			PTHR11911:SF121	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2
P00021	FGF signaling pathway	P00632	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IGI	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00021	FGF signaling pathway	P00634	MEKK1-5	MACMU|Ensembl=ENSMMUG00000018568|UniProtKB=F6YLW2	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00054	Toll receptor signaling pathway	P01375	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CAEEL|WormBase=WBGene00001648|UniProtKB=P51875	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00628	JNK1-3	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	MOUSE|MGI=MGI=88256|UniProtKB=P11798	Calcium/calmodulin-dependent protein kinase type II subunit alpha	IDA	12888804	PubMed	PTHR43940:SF5	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01465	Ggamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IDA	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04393	Ras Pathway	P04567	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IDA	7565716	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000016187|UniProtKB=F1N213	Uncharacterized protein	ISS	11431030	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00235	c-Fos	RAT|RGD=2626|UniProtKB=P12841	Proto-oncogene c-Fos	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10755300	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04393	Ras Pathway	P04572	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IDA	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P05918	p38 MAPK pathway	P05921	MKP5	MACMU|Ensembl=ENSMMUG00000004379|UniProtKB=F7FRM2	Dual specificity protein phosphatase 10 isoform a	ISS	10597297	PubMed	PTHR10159:SF299	DUAL SPECIFICITY PROTEIN PHOSPHATASE 10
P06587	Nicotine pharmacodynamics pathway	P06608	DDC	RAT|RGD=2494|UniProtKB=P14173	Aromatic-L-amino-acid decarboxylase	TAS	90339966	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P04393	Ras Pathway	P04570	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01230	Src kinase	TAKRU|Ensembl=ENSTRUG00000004669|UniProtKB=H2SFA3	Tyrosine-protein kinase	IDA	8054685	PubMed	PTHR24418:SF181	TYROSINE-PROTEIN KINASE BLK
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	PANTR|Ensembl=ENSPTRG00000014976|UniProtKB=H2R892	Uncharacterized protein	ISS			PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8973|UniProtKB=O75747	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS			PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00021	FGF signaling pathway	P00648	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	HUMAN|HGNC=1392|UniProtKB=Q15878	Voltage-dependent R-type calcium channel subunit alpha-1E	IDA	11976940	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00060	Ubiquitin proteasome pathway	P01490	E3	MACMU|Ensembl=ENSMMUG00000011325|UniProtKB=F6UEX6	Ubiquitin-conjugating enzyme E2 K	ISS			PTHR44020:SF2	UBIQUITIN-CONJUGATING ENZYME E2 K
P04393	Ras Pathway	P04557	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00048	PI3 kinase pathway	P01206	14-3-3	CANLF|Ensembl=ENSCAFG00000000580|UniProtKB=F1PBL1	Uncharacterized protein	ISS	12615066	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04393	Ras Pathway	P04556	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IDA	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS			PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	ISS	15531926	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	BOVIN|Ensembl=ENSBTAG00000002125|UniProtKB=F1N461	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P02723	Adenine and hypoxanthine salvage pathway	P02804	Hypoxanthine phosphoribosyl transferase	CAEBR|Gene=CBG19800|UniProtKB=A8XWA1	Protein CBG19800	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00021	FGF signaling pathway	P00634	MEKK1-5	DROME|FlyBase=FBgn0014006|UniProtKB=Q9VDS9	Apoptotic signal-regulating kinase 1, isoform C	ISS			PTHR11584:SF369	APOPTOTIC SIGNAL-REGULATING KINASE 1, ISOFORM C
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000010392|UniProtKB=F7ASR8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	ANOGA|EnsemblGenome=AGAP000445|UniProtKB=Q7PRU8	AGAP000445-PA	IDA	12515326	PubMed	PTHR24246:SF27	ADENOSINE RECEPTOR A2A
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	HUMAN|HGNC=4404|UniProtKB=P59768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IDA	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_94959|UniProtKB=C3XYC4	Putative uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	IDA	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	P01465	Ggamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000011231|UniProtKB=F6WXV4	Uncharacterized protein	ISS	11431030	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00010	B cell activation	P00397	IKK	RAT|RGD=621375|UniProtKB=Q9QY78	Inhibitor of nuclear factor kappa-B kinase subunit beta	IGI	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00878	INFgamma	RAT|RGD=2866|UniProtKB=P01581	Interferon gamma	TAS	11929133	PubMed	PTHR11419:SF0	INTERFERON GAMMA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	HUMAN|HGNC=1392|UniProtKB=Q15878	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	14624853	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P04372	5-Hydroxytryptamine degredation	P04401	Monoamine Oxidase	MOUSE|MGI=MGI=96916|UniProtKB=Q8BW75	Amine oxidase [flavin-containing] B	ISS	8602220	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P00048	PI3 kinase pathway	P01192	p110	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=69430|UniProtKB=P32851	Syntaxin-1A	IC	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00044	Nicotinic acetylcholine receptor signaling pathway	P01087	CAT	DROME|FlyBase=FBgn0000303|UniProtKB=P07668	Choline O-acetyltransferase	IC	92155737	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	IC	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00754	PDEgamma	MONDO|Ensembl=ENSMODG00000002709|UniProtKB=F7CXV2	Uncharacterized protein	ISS	P54827	SPACC	PTHR12122:SF4	RETINAL ROD RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT GAMMA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00018	EGF receptor signaling pathway	P00558	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00795	BDNF	CHICK|Ensembl=ENSGALG00000012163|UniProtKB=P25429	Brain-derived neurotrophic factor	TAS	11408619	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00034	Integrin signalling pathway	P00920	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00009	Axon guidance mediated by netrin	P00366	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00018	EGF receptor signaling pathway	P00565	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00056	VEGF signaling pathway	P01417	Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	YEAST|SGD=S000003174|UniProtKB=P22137	Clathrin heavy chain	IDA	9388255	PubMed	PTHR10292:SF1	CLATHRIN HEAVY CHAIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000007882|UniProtKB=G3X7Z2	Uncharacterized protein	ISS	11976940	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CANLF|Ensembl=ENSCAFG00000002617|UniProtKB=E2QUL1	Uncharacterized protein	ISS	14698601	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00052	TGF-beta signaling pathway	P01275	P38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	TAS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00057	Wnt signaling pathway	P01443	Phospholipase C	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IDA	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00018	EGF receptor signaling pathway	P00562	p38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	ISS	176892	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01284	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05731	GABA-B receptor II signaling	P05754	Ggamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00049	Parkinson disease	P01238	14-3-3	CHICK|Gene_ORFName=RCJMB04_1e8|UniProtKB=Q5ZMT0	14-3-3 protein epsilon	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00053	T cell activation	P01335	jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01162	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05730	Endogenous cannabinoid signaling	P05751	Galpha	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	RCA	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P02751	Lysine biosynthesis	P03013	Aspartate semialdehyde dehydrogenase	ORYSJ|EnsemblGenome=OS01G0926800|UniProtKB=Q8S1X5	Os01g0926800 protein	ISS			PTHR10174:SF158	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	MOUSE|MGI=MGI=109482|UniProtKB=P97445	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	IDA	8386525	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01021	Vglut	PANTR|Ensembl=ENSPTRG00000003444|UniProtKB=H2R3D0	Uncharacterized protein	ISS	12815758	PubMed	PTHR11662:SF201	VESICULAR GLUTAMATE TRANSPORTER 2
P00010	B cell activation	P00367	NFAT	HUMAN|HGNC=7777|UniProtKB=Q12968	Nuclear factor of activated T-cells, cytoplasmic 3	IDA	9462517	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P05918	p38 MAPK pathway	P06034	MKK4	MACMU|Ensembl=ENSMMUG00000019842|UniProtKB=F7FU91	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00114	actin	SCLS1|Gene=SS1G_08733|UniProtKB=A7ETS6	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	DROME|FlyBase=FBgn0037121|UniProtKB=Q9VNZ3	GM03174p	ISS	606023	OMIM	PTHR10917:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3
P04398	p53 pathway feedback loops 2	P04651	Ras	XENTR|Xenbase=XB-GENE-494548|UniProtKB=F7EC26	Uncharacterized protein	ISS	10825661	PubMed	PTHR24070:SF186	GTPASE KRAS
P04393	Ras Pathway	P04557	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g234494|UniProtKB=A7RU31	Predicted protein	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05915	Opioid proenkephalin pathway	P05994	G-protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	IC	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00025	Hedgehog signaling pathway	P00683	Slimb	MONDO|Ensembl=ENSMODG00000006464|UniProtKB=F7FGS3	Uncharacterized protein	ISS	12628165	PubMed	PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	MACMU|Ensembl=ENSMMUG00000003024|UniProtKB=F6VN73	Uncharacterized protein	ISS			PTHR26392:SF77	EXTRACELLULAR TYROSINE-PROTEIN KINASE PKDCC
P04393	Ras Pathway	P04556	Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	IDA	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00037	Ionotropic glutamate receptor pathway	P01015	Glu4	TAKRU|Ensembl=ENSTRUG00000011517|UniProtKB=H2TWL9	Uncharacterized protein (Fragment)	ISS	10331083	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	ISS	176910	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00790	beta-Tubulin	CAEBR|Gene=CBG18319|UniProtKB=A8XSF1	Protein CBR-TBB-1	ISS	12932731	PubMed	PTHR11588:SF157	TUBULIN, BETA
P05730	Endogenous cannabinoid signaling	P05748	mGluR	MACMU|Ensembl=ENSMMUG00000010184|UniProtKB=F6SR09	Uncharacterized protein	ISS	7476890	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02776	Serine glycine biosynthesis	P03159	Phosphoserine phosphatase	ECOLI|EcoGene=EG10945|UniProtKB=P0AGB0	Phosphoserine phosphatase	ISS			PTHR43344:SF2	PHOSPHOSERINE PHOSPHATASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CHLRE|EnsemblGenome=CHLREDRAFT_193901|UniProtKB=Q9FXT7	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P04397	p53 pathway by glucose deprivation	P04645	TSC1	HUMAN|HGNC=12362|UniProtKB=Q92574	Hamartin	IDA	12820960	PubMed	PTHR15154:SF2	HAMARTIN
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00006	Apoptosis signaling pathway	P00279	endoG	HUMAN|HGNC=3346|UniProtKB=Q14249	Endonuclease G, mitochondrial	ISS			PTHR13966:SF5	ENDONUCLEASE G, MITOCHONDRIAL
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00047	PDGF signaling pathway	P01161	Raf	MOUSE|MGI=MGI=88190|UniProtKB=P28028	Serine/threonine-protein kinase B-raf	ISS	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00059	p53 pathway	P04630	PP2A	TAKRU|Ensembl=ENSTRUG00000008018|UniProtKB=H2T5N4	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00011	Blood coagulation	P00415	Plasmin	PANTR|Ensembl=ENSPTRG00000018774|UniProtKB=H2QU06	Plasminogen	ISS	2318848	PubMed	PTHR24261:SF6	PLASMINOGEN
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	PANTR|Ensembl=ENSPTRG00000011741|UniProtKB=H2R8X1	Uncharacterized protein	ISS	11034345	PubMed	PTHR11647:SF58	DIHYDROPYRIMIDINASE-RELATED PROTEIN 5
P00057	Wnt signaling pathway	P01448	CBP	CAEEL|WormBase=WBGene00000366|UniProtKB=P34545	Protein cbp-1	ISS	8413673	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	DANRE|ZFIN=ZDB-GENE-051202-2|UniProtKB=Q6ZM67	Uncharacterized protein	ISS	11554554	PubMed	PTHR44391:SF3	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MACMU|Ensembl=ENSMMUG00000019112|UniProtKB=F6T8S6	N-methyl D-aspartate receptor subtype 2B	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	TAS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00021	FGF signaling pathway	P00624	14-3-3	CHICK|Ensembl=ENSGALG00000004143|UniProtKB=Q5ZLQ6	14-3-3 protein beta/alpha	ISS	1671102	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00036	Interleukin signaling pathway	P00964	p90RSK	MACMU|Ensembl=ENSMMUG00000020532|UniProtKB=F7D8E6	Ribosomal protein S6 kinase	ISS	15632195	PubMed	PTHR24351:SF98	RIBOSOMAL PROTEIN S6 KINASE ALPHA-6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00029	Huntington disease	P00807	Actin	DANRE|ZFIN=ZDB-GENE-040426-2894|UniProtKB=Q7SXW6	Actin-related protein 2-A	ISS	11889126	PubMed	PTHR11937:SF149	ACTIN-RELATED PROTEIN 2-A-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	ISS	13430383	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	PANTR|Ensembl=ENSPTRG00000004718|UniProtKB=H2Q5I0	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00021	FGF signaling pathway	P00632	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IGI	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	PANTR|Ensembl=ENSPTRG00000001202|UniProtKB=H2PZT8	Uncharacterized protein	ISS	12629106	PubMed	PTHR24241:SF116	GONADOTROPIN-RELEASING HORMONE II RECEPTOR-RELATED
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00021	FGF signaling pathway	P00629	PP2A	DANRE|ZFIN=ZDB-GENE-080219-32|UniProtKB=A9JRC7	Serine/threonine-protein phosphatase 4 catalytic subunit B	ISS			PTHR11668:SF22	SERINE/THREONINE-PROTEIN PHOSPHATASE 4 CATALYTIC SUBUNIT
P00057	Wnt signaling pathway	P01443	Phospholipase C	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	IDA	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00022	General transcription by RNA polymerase I	P00657	TBP	MONDO|Ensembl=ENSMODG00000017515|UniProtKB=F7F0J5	Uncharacterized protein	ISS	600075	OMIM	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9063|UniProtKB=Q15111	Inactive phospholipase C-like protein 1	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P00021	FGF signaling pathway	P00624	14-3-3	CHICK|Gene_ORFName=RCJMB04_5e12|UniProtKB=Q5F3W6	14-3-3 protein gamma	ISS	91108808	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04398	p53 pathway feedback loops 2	G04715	CYCLIN G	PANTR|Ensembl=ENSPTRG00000017501|UniProtKB=H2QRY5	Cyclin G1	ISS			PTHR10177:SF59	CYCLIN-G1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	BOVIN|Gene=RGS9|UniProtKB=O46469	Regulator of G-protein signaling 9	IDA	9459445	PubMed	PTHR10845:SF170	REGULATOR OF G-PROTEIN SIGNALING 9
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	TRIAD|EnsemblGenome=TriadG63380|UniProtKB=B3S653	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00006	Apoptosis signaling pathway	P00322	Cytochrome C	MOUSE|MGI=MGI=88579|UniProtKB=P00015	Cytochrome c, testis-specific	ISS			PTHR11961:SF6	CYTOCHROME C, TESTIS-SPECIFIC
P00034	Integrin signalling pathway	P00916	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00060	Ubiquitin proteasome pathway	P01490	E3	MOUSE|MGI=MGI=1913563|UniProtKB=A2A5Z6	E3 ubiquitin-protein ligase SMURF2	ISS	11252892	PubMed	PTHR11254:SF300	E3 UBIQUITIN-PROTEIN LIGASE SMURF2
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8697|UniProtKB=Q9Y5H3	Protocadherin gamma-A10	IDA	8120095	PubMed	PTHR24028:SF110	PROTOCADHERIN GAMMA-A10
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00167	CD44 transmembrane fragment	PANTR|Ensembl=ENSPTRG00000003501|UniProtKB=H2Q3E8	Uncharacterized protein	ISS	14871815	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P02768	Proline biosynthesis	P03114	Glutamyl kinase	THEMA|EnsemblGenome=TM_0294|UniProtKB=Q9WYD0	Glutamate 5-kinase	ISS			PTHR43654:SF3	GLUTAMATE 5-KINASE
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=1850|UniProtKB=Q9NYQ6	Cadherin EGF LAG seven-pass G-type receptor 1	IDA	8120095	PubMed	PTHR24026:SF36	CADHERIN EGF LAG SEVEN-PASS G-TYPE RECEPTOR 1
P00034	Integrin signalling pathway	P00939	Fibronectin	MOUSE|MGI=MGI=95566|UniProtKB=P11276	Fibronectin	ISS	12970173	PubMed	PTHR19143:SF267	FIBRONECTIN
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	12846562	PubMed	PTHR10202:SF13	PRESENILIN-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ORNAN|Ensembl=ENSOANG00000000460|UniProtKB=F7F4W9	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	SCHPO|PomBase=SPBC12D12.04c|UniProtKB=P36583	Protein kinase C-like 2	IC	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04393	Ras Pathway	P04553	PAK	BOVIN|Ensembl=ENSBTAG00000010191|UniProtKB=Q08E52	Serine/threonine-protein kinase PAK 1	ISS	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	MONDO|Ensembl=ENSMODG00000015573|UniProtKB=F7AIP6	Uncharacterized protein (Fragment)	ISS	9118222	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	XENTR|Xenbase=XB-GENE-1010483|UniProtKB=F7AF72	Uncharacterized protein	ISS	20112749	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00021	FGF signaling pathway	P00640	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	IGI	9620264	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00052	TGF-beta signaling pathway	P01292	RSmads	MACMU|Ensembl=ENSMMUG00000009914|UniProtKB=F6YCR1	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF41	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 9
P00053	T cell activation	P01336	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00029	Huntington disease	P00786	ARF	CAEEL|WormBase=WBGene00000184|UniProtKB=Q9U2S4	ADP-Ribosylation Factor related	IPI	12932731	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00057	Wnt signaling pathway	P01444	Wnt	MACMU|Ensembl=ENSMMUG00000006915|UniProtKB=F7EZ32	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	TAKRU|Ensembl=ENSTRUG00000001238|UniProtKB=H2RRV9	Glutamine synthetase	ISS			PTHR20852:SF45	GLUTAMINE SYNTHETASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT1G07880|UniProtKB=Q9LQQ9	Mitogen-activated protein kinase 13	ISS	11707292	PubMed	PTHR24055:SF185	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00010	B cell activation	P00401	jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	CHICK|Ensembl=ENSGALG00000001334|UniProtKB=F1NLV4	Uncharacterized protein	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00050	Plasminogen activating cascade	P01257	tPA	RAT|RGD=3342|UniProtKB=P19637	Tissue-type plasminogen activator	ISS	137121	gi	PTHR44617:SF1	TISSUE-TYPE PLASMINOGEN ACTIVATOR
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=12782|UniProtKB=P56703	Proto-oncogene Wnt-3	IDA	11266476	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	HUMAN|HGNC=4581|UniProtKB=Q13003	Glutamate receptor ionotropic, kainate 3	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	MOUSE|MGI=MGI=96600|UniProtKB=Q62469	Integrin alpha-2	IDA	10727440	PubMed	PTHR23220:SF23	INTEGRIN ALPHA-2
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00200	Dsh	MONDO|Ensembl=ENSMODG00000003229|UniProtKB=F6TYA8	Uncharacterized protein (Fragment)	ISS	10409711	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P02756	N-acetylglucosamine metabolism	P03040	N-acetylneuraminate lyase	TRIVA|Gene=TVAG_044970|UniProtKB=A2E8E5	N-acetylneuraminate lyase, putative	ISS			PTHR42849:SF1	N-ACETYLNEURAMINATE LYASE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	10693759	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00590	IP3 R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	ISS	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04376	5HT4 type receptor mediated signaling pathway	P04426	K+ channel	HUMAN|HGNC=6283|UniProtKB=Q9NPC2	Potassium channel subfamily K member 9	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00018	EGF receptor signaling pathway	P00541	Spry	PANTR|Ensembl=ENSPTRG00000017360|UniProtKB=H2QRP3	Uncharacterized protein	ISS	10330503	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DICDI|dictyBase=DDB_G0277143|UniProtKB=P36408	Guanine nucleotide-binding protein subunit beta	IC	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00049	Parkinson disease	P01211	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MACMU|Ensembl=ENSMMUG00000009763|UniProtKB=F6ZIC3	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF368	MYOSIN-8
P00056	VEGF signaling pathway	P01418	Paxillin	MOUSE|MGI=MGI=108295|UniProtKB=Q8VI36	Paxillin	IDA	7579684	PubMed	PTHR24216:SF11	PAXILLIN
P00009	Axon guidance mediated by netrin	P00363	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01152	RasGAP	HUMAN|HGNC=9871|UniProtKB=P20936	Ras GTPase-activating protein 1	ISS	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00047	PDGF signaling pathway	P01167	Ets	RAT|RGD=2583|UniProtKB=P41156	Protein C-ets-1	ISS	15298723	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	YEAST|SGD=S000004520|UniProtKB=P50094	Inosine-5'-monophosphate dehydrogenase 4	ISS			PTHR11911:SF111	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE
P00049	Parkinson disease	P01211	ERK	ORYSJ|EnsemblGenome=OS06G0699400|UniProtKB=Q5Z859	Mitogen-activated protein kinase 4	IDA	7341300	gi	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	RAT|RGD=3187|UniProtKB=Q07008	Neurogenic locus notch homolog protein 1	IDA	1764995	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00048	PI3 kinase pathway	P01192	p110	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04658	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=69430|UniProtKB=P32851	Syntaxin-1A	IC	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Ensembl=ENSPTRG00000017441|UniProtKB=H2QRU7	Glutamate receptor, ionotropic, AMPA 1	ISS	12941441	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00019	Endothelin signaling pathway	P00566	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	21186066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01167	Ets	PANTR|Ensembl=ENSPTRG00000004467|UniProtKB=H2R2K3	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF161	FRIEND LEUKEMIA INTEGRATION 1 TRANSCRIPTION FACTOR
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PHYPA|Gene=PHYPADRAFT_226658|UniProtKB=A9TYG3	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=8156|UniProtKB=P35372	Mu-type opioid receptor	IDA	11259498	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00057	Wnt signaling pathway	P01444	Wnt	PANTR|Ensembl=ENSPTRG00000001108|UniProtKB=H2PZP0	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P04393	Ras Pathway	P04570	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00985	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00019	Endothelin signaling pathway	P00570	PKA	LEIMA|EnsemblGenome=LmjF.18.1080|UniProtKB=Q27687	Protein kinase A catalytic subunit	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00774	Dynein complex	MONDO|Ensembl=ENSMODG00000009584|UniProtKB=F7AWC8	Uncharacterized protein	ISS	9454836	PubMed	PTHR11886:SF2	DYNEIN LIGHT CHAIN 4, AXONEMAL
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00010	B cell activation	P00381	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	10218114	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04398	p53 pathway feedback loops 2	P04665	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00775	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00269	MAPK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00053	T cell activation	P01300	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05915	Opioid proenkephalin pathway	P05991	Enkephalin	MACMU|Ensembl=ENSMMUG00000006775|UniProtKB=F7H3N8	Uncharacterized protein	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	RAT|RGD=3187|UniProtKB=Q07008	Neurogenic locus notch homolog protein 1	IDA	1764995	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P05913	Enkephalin release	P05978	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00059	p53 pathway	P04609	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P02747	Histidine biosynthesis	P02987	ATP phosphoribosyl transferase	ARATH|TAIR=AT1G58080|UniProtKB=Q9S762	ATP phosphoribosyltransferase 1, chloroplastic	ISS			PTHR21403:SF6	ATP PHOSPHORIBOSYLTRANSFERASE 1, CHLOROPLASTIC-RELATED
P00029	Huntington disease	P00805	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01161	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00944	Actin	HUMAN|HGNC=144|UniProtKB=P63261	Actin, cytoplasmic 2	IPI	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P02784	Tyrosine biosynthesis	P03214	Prephenate dehydrogenase	LEPIN|EnsemblGenome=LA_1257|UniProtKB=Q8F6P6	Bifunctional prephenate dehydrogenase/chorismate mutase	ISS			PTHR21363:SF0	PREPHENATE DEHYDROGENASE  NADP +
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BOVIN|Ensembl=ENSBTAG00000012914|UniProtKB=F1MHG3	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00053	T cell activation	P01307	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00019	Endothelin signaling pathway	P00568	PKC	CAEEL|WormBase=WBGene00018620|UniProtKB=O44588	Uncharacterized protein	ISS	2837282	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P04393	Ras Pathway	P04557	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00022	General transcription by RNA polymerase I	P00652	RNA Polymerase I  Complex	RAT|RGD=620822|UniProtKB=O54888	DNA-directed RNA polymerase I subunit RPA2	ISS	15691654	PubMed	PTHR20856:SF5	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA2
P00020	FAS signaling pathway	P00610	MKK4	MONDO|Ensembl=ENSMODG00000008266|UniProtKB=F6Z879	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00029	Huntington disease	P00797	p53	XENTR|Xenbase=XB-GENE-922699|UniProtKB=F6XLU1	Uncharacterized protein	ISS			PTHR12195:SF1	CYTOPLASMIC FMR1-INTERACTING PROTEIN 2
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MOUSE|MGI=MGI=1202879|UniProtKB=Q924A0	Transcription factor 7-like 2	IEP	12356903	PubMed	PTHR10373:SF32	TRANSCRIPTION FACTOR 7-LIKE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00021	FGF signaling pathway	P00628	JNK1-3	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS			PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	10553940	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P04393	Ras Pathway	P04548	ATF2	HUMAN|HGNC=784|UniProtKB=P15336	Cyclic AMP-dependent transcription factor ATF-2	ISS	10487205	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05915	Opioid proenkephalin pathway	P05990	K+ channel	HUMAN|HGNC=6283|UniProtKB=Q9NPC2	Potassium channel subfamily K member 9	ISS	15282272	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00053	T cell activation	P01332	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	BOVIN|Ensembl=ENSBTAG00000002125|UniProtKB=F1N461	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P02757	O-antigen biosynthesis	P03045	dTDP-glucose 4,6-dehydratase	DEIRA|EnsemblGenome=DR_A0041|UniProtKB=Q9RZB3	dTDP-glucose 4,6-dehydratase	ISS			PTHR43000:SF7	DTDP-D-GLUCOSE 4,6-DEHYDRATASE
P00052	TGF-beta signaling pathway	P01275	P38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00003	Alzheimer disease-amyloid secretase pathway	P00107	kinesin	CANLF|Ensembl=ENSCAFG00000001787|UniProtKB=E2RCD4	Uncharacterized protein	ISS	11740561	PubMed	PTHR19959:SF139	KINESIN LIGHT CHAIN 4
P00049	Parkinson disease	P01211	ERK	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	IDA	11707292	PubMed	PTHR24055:SF330	SUBFAMILY NOT NAMED
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	RAT|RGD=735092|UniProtKB=E9PU28	Inosine-5'-monophosphate dehydrogenase 2	ISS			PTHR11911:SF121	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2
P00049	Parkinson disease	P01219	SAPK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	NAS	97102676	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	IC	9199552	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00780	Microtubule	LEIMA|EnsemblGenome=LmjF.08.1230|UniProtKB=Q4QI42	Beta tubulin	IDA	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IC	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00402	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00003	Alzheimer disease-amyloid secretase pathway	P00107	kinesin	CAEEL|WormBase=WBGene00002214|UniProtKB=H9G2T2	Kinesin Light Chain	IDA	11740561	PubMed	PTHR19959:SF207	KINESIN LIGHT CHAIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	PANTR|Ensembl=ENSPTRG00000001144|UniProtKB=H2PZR0	Uncharacterized protein	ISS	3017658	PubMed	PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P00010	B cell activation	P00385	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12874273	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00029	Huntington disease	P00777	CBP	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00046	Oxidative stress response	P01123	Bcl-2	BOVIN|Gene=BCL2|UniProtKB=O02718	Apoptosis regulator Bcl-2	ISS	2250705	PubMed	PTHR11256:SF11	APOPTOSIS REGULATOR BCL-2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	MACMU|Ensembl=ENSMMUG00000017921|UniProtKB=F7EDG8	Uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF335	CALMODULIN, STRIATED MUSCLE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MONDO|Ensembl=ENSMODG00000001303|UniProtKB=F7BZM9	Uncharacterized protein (Fragment)	ISS	12473693	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00049	Parkinson disease	P01227	20S proteasome	ARATH|TAIR=AT1G77440|UniProtKB=O81153	Proteasome subunit beta type-3-B	TAS	12859888	PubMed	PTHR11599:SF62	PROTEASOME SUBUNIT BETA TYPE-3
P00004	Alzheimer disease-presenilin pathway	P00111	C99	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00049	Parkinson disease	P01211	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	97102671	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00006	Apoptosis signaling pathway	P00317	Fos	RAT|RGD=2626|UniProtKB=P12841	Proto-oncogene c-Fos	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00030	Hypoxia response via HIF activation	P00818	HIF-1alpha	HUMAN|HGNC=4910|UniProtKB=Q16665	Hypoxia-inducible factor 1-alpha	TAS	14526383	PubMed	PTHR23043:SF7	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00029	Huntington disease	P00796	Kainate receptor	PANTR|Ensembl=ENSPTRG00000018449|UniProtKB=H2QTG5	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00029	Huntington disease	P00778	NMDA receptor	MOUSE|MGI=MGI=2150393|UniProtKB=Q91ZU9	Glutamate receptor ionotropic, NMDA 3B	IDA	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P04393	Ras Pathway	P04570	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	BOVIN|Ensembl=ENSBTAG00000016187|UniProtKB=F1N213	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	BOVIN|Ensembl=ENSBTAG00000002107|UniProtKB=A7MB15	FZD1 protein	ISS	12549854	PubMed	PTHR11309:SF81	FRIZZLED-1
P05730	Endogenous cannabinoid signaling	P05751	Galpha	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P02753	Methionine biosynthesis	P03024	Homocysteine transmethylase	ORYSJ|EnsemblGenome=OS01G0772900|UniProtKB=Q5ZBZ6	Os01g0772900 protein	ISS			PTHR21091:SF159	HOMOCYSTEINE S-METHYLTRANSFERASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00212	EphR	ORNAN|Ensembl=ENSOANG00000000485|UniProtKB=F7EX10	Uncharacterized protein	ISS			PTHR24416:SF18	EPHRIN TYPE-A RECEPTOR 3
P04393	Ras Pathway	P04556	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05918	p38 MAPK pathway	P06020	p38delta	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	RCA	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	IC	15313841	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	BOVIN|Ensembl=ENSBTAG00000011723|UniProtKB=E1BKL6	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MOUSE|MGI=MGI=106213|UniProtKB=Q9R0W9	Neuronal acetylcholine receptor subunit alpha-6	IC	85270494	PubMed	PTHR18945:SF82	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-6
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04393	Ras Pathway	P04560	AP1	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00018	EGF receptor signaling pathway	P00555	MKK4,7	MONDO|Ensembl=ENSMODG00000008266|UniProtKB=F6Z879	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00015	Circadian clock system	G01503	per	CHICK|Gene=PER2|UniProtKB=Q8QGQ8	Period circadian protein homolog 2	ISS	21236844	PubMed	PTHR11269:SF9	PERIOD CIRCADIAN PROTEIN HOMOLOG 2
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	IDA	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00053	T cell activation	P01312	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IDA	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00053	T cell activation	P01320	PLC-gamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PHANO|EnsemblGenome=SNOG_01139|UniProtKB=H2KNE6	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00060	Ubiquitin proteasome pathway	P01491	E2	LEIMA|EnsemblGenome=LmjF.13.1580|UniProtKB=Q4QFZ6	Ubiquitin-conjugating enzyme-like protein	ISS			PTHR43915:SF5	LD28904P
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=107469|UniProtKB=Q8K3R3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	12860966	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	MACMU|Ensembl=ENSMMUG00000022009|UniProtKB=F6RBZ7	Cell division control protein 42 homolog isoform 2	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IDA	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00034	Integrin signalling pathway	P00931	Integrin beta	BOVIN|Ensembl=ENSBTAG00000009987|UniProtKB=F1MTN1	Integrin beta	ISS	4206165	gi	PTHR10082:SF25	INTEGRIN BETA-3
P04397	p53 pathway by glucose deprivation	P04641	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IDA	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	RCA			PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	DROME|FlyBase=FBgn0016797|UniProtKB=Q9VVX3	Frizzled-2	TAS	11212302	PubMed	PTHR11309:SF90	FRIZZLED-8
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	HUMAN|HGNC=7883|UniProtKB=Q9UM47	Neurogenic locus notch homolog protein 3	IDA	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	MACMU|Ensembl=ENSMMUG00000008351|UniProtKB=F7HRV5	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01440	Cadherin	DROME|FlyBase=FBgn0261574|UniProtKB=Q9VW71	Fat-like cadherin-related tumor suppressor homolog	ISS	8120095	PubMed	PTHR24026:SF71	FAT-LIKE CADHERIN-RELATED TUMOR SUPPRESSOR HOMOLOG
P00057	Wnt signaling pathway	P01465	Ggamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	ISS	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00034	Integrin signalling pathway	P00924	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	IPI	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DANRE|ZFIN=ZDB-GENE-040426-1178|UniProtKB=Q7SY24	Protein kinase C beta type	ISS	11880265	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IGI	91072385	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04393	Ras Pathway	P04558	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	IDA	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00053	T cell activation	P01294	NFAT	MOUSE|MGI=MGI=103296|UniProtKB=P97305	Nuclear factor of activated T-cells, cytoplasmic 3	IGI	9133421	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	PANTR|Ensembl=ENSPTRG00000008173|UniProtKB=H2QB81	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF25	MATRIX METALLOPROTEINASE-15
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01142	p90RSK	BOVIN|Ensembl=ENSBTAG00000010906|UniProtKB=E1BN61	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF115	RIBOSOMAL PROTEIN S6 KINASE ALPHA-5
P00047	PDGF signaling pathway	P01160	IP3 receptor	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00037	Ionotropic glutamate receptor pathway	P01026	KA	CHICK|Ensembl=ENSGALG00000015434|UniProtKB=F1NU20	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P02738	De novo purine biosynthesis	P02891	GDP kinase	YEAST|SGD=S000001550|UniProtKB=P36010	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P05734	Synaptic vesicle trafficking	P05779	Synaptobrevin	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00048	PI3 kinase pathway	P01188	Gbetagamma	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04398	p53 pathway feedback loops 2	P04651	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	87226391	PubMed	PTHR24070:SF385	GTPASE HRAS
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	BACSU|EnsemblGenome=BSU22960|UniProtKB=P50735	Cryptic catabolic NAD-specific glutamate dehydrogenase GudB	ISS			PTHR11606:SF13	GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00029	Huntington disease	P00778	NMDA receptor	MOUSE|MGI=MGI=1933206|UniProtKB=A2AIR5	Protein Grin3a	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P02747	Histidine biosynthesis	P02993	Phosphoribosylformimino-5-amino-1-phosphoribosyl-4 imadazol carboxamide isomerase	BACSU|EnsemblGenome=BSU34880|UniProtKB=O35006	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase	ISS			PTHR43090:SF2	1- 5-PHOSPHORIBOSYL -5-  5-PHOSPHORIBOSYLAMINO METHYLIDENEAMINO  IMIDAZOLE-4-CARBOXAMIDE ISOMERASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04398	p53 pathway feedback loops 2	P04657	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	11832947	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=101848|UniProtKB=P62881	Guanine nucleotide-binding protein subunit beta-5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05916	Opioid prodynorphin pathway	P06002	G-protein	XENTR|Xenbase=XB-GENE-961282|UniProtKB=Q6DF43	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	MACMU|Ensembl=ENSMMUG00000014334|UniProtKB=F7CYY6	Uncharacterized protein	ISS	11248120	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00019	Endothelin signaling pathway	P00578	eNOS	RAT|RGD=3186|UniProtKB=Q62600	Nitric oxide synthase, endothelial	ISS	10435050	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04572	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	IDA	12040174	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00017	DNA replication	P00529	RFC	HUMAN|HGNC=9969|UniProtKB=P35251	Replication factor C subunit 1	RCA			PTHR23389:SF22	REPLICATION FACTOR C SUBUNIT 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00029	Huntington disease	P00796	Kainate receptor	RAT|RGD=2735|UniProtKB=Q63273	Glutamate receptor ionotropic, kainate 5	IDA	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00018	EGF receptor signaling pathway	P00547	PP2A	CAEBR|Gene=CBG23076|UniProtKB=A8Y4R8	Protein CBR-PPTR-2	ISS	10092233	PubMed	PTHR10257:SF3	PP2A-B', ISOFORM B
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IC	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00005	Angiogenesis	P00223	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05917	Opioid proopiomelanocortin pathway	P06004	Mu or Delta receptor	HUMAN|HGNC=8153|UniProtKB=P41143	Delta-type opioid receptor	RCA	11259487	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	ORYSJ|EnsemblGenome=OS01G0178000|UniProtKB=Q94EG1	Os01g0178000 protein	ISS			PTHR43795:SF12	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04669	ATM	MACMU|Ensembl=ENSMMUG00000007927|UniProtKB=F7HT00	Uncharacterized protein	ISS	10196661	PubMed	PTHR11139:SF69	SERINE/THREONINE-PROTEIN KINASE ATR
P00048	PI3 kinase pathway	P01177	P110ACT	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00925	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00127	APP	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04580	TRH Receptor	HUMAN|HGNC=12299|UniProtKB=P34981	Thyrotropin-releasing hormone receptor	ISS	7509436	PubMed	PTHR24243:SF115	THYROTROPIN-RELEASING HORMONE RECEPTOR
P00029	Huntington disease	P00776	c-Jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00005	Angiogenesis	P00223	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	TAKRU|Ensembl=ENSTRUG00000011297|UniProtKB=H2TV18	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00021	FGF signaling pathway	P00638	PLCgamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	MACMU|Ensembl=ENSMMUG00000011231|UniProtKB=F6WXV4	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	CANAL|CGD=CAL0000177227|UniProtKB=P43072	Transcription factor IIIB 70 kDa subunit	ISS			PTHR11618:SF4	TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT
P00021	FGF signaling pathway	P00627	ERK1-2	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IGI	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	IGI	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00045	Notch signaling pathway	P01114	Ntm	RAT|RGD=3188|UniProtKB=Q9QW30	Neurogenic locus notch homolog protein 2	IEP	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MOUSE|MGI=MGI=99673|UniProtKB=P84309	Adenylate cyclase type 5	ISS	93156838	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	MOUSE|MGI=MGI=99779|UniProtKB=P49582	Neuronal acetylcholine receptor subunit alpha-7	ISS	11404397	PubMed	PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P00011	Blood coagulation	P00450	Tissue Factor	PANTR|Ensembl=ENSPTRG00000000977|UniProtKB=H2R022	Tissue factor	ISS	4503641	gi	PTHR20859:SF22	TISSUE FACTOR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	BOVIN|Ensembl=ENSBTAG00000039772|UniProtKB=F6QI78	Uncharacterized protein	ISS			PTHR24247:SF31	5-HYDROXYTRYPTAMINE RECEPTOR 2B
P00049	Parkinson disease	P01230	Src kinase	RAT|RGD=1308800|UniProtKB=P32577	Tyrosine-protein kinase CSK	ISS	7687537	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P05916	Opioid prodynorphin pathway	P06002	G-protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000020224|UniProtKB=H2Q9G3	Mitogen-activated protein kinase 6	ISS	8444355	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00243	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00562	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00054	Toll receptor signaling pathway	P01346	TLR	CHICK|Gene=TLR2-1|UniProtKB=Q9DD78	Toll-like receptor 2 type-1	ISS			PTHR24365:SF17	TOLL-LIKE RECEPTOR 2
P00004	Alzheimer disease-presenilin pathway	P00165	E-cadherin N-terminal fragment	HUMAN|HGNC=1762|UniProtKB=P22223	Cadherin-3	TAS	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MONDO|Ensembl=ENSMODG00000016960|UniProtKB=F6V5G0	Uncharacterized protein	ISS			PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=4594|UniProtKB=Q14416	Metabotropic glutamate receptor 2	IDA	20012997	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00010	B cell activation	P00398	IP3R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04396	Vitamin D metabolism and pathway	P04602	RXR	MOUSE|MGI=MGI=98214|UniProtKB=P28700	Retinoic acid receptor RXR-alpha	RCA			PTHR24083:SF39	RETINOIC ACID RECEPTOR RXR-ALPHA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8717|UniProtKB=Q9Y5F7	Protocadherin gamma-C4	IDA	8120095	PubMed	PTHR24028:SF137	PROTOCADHERIN GAMMA-C4
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00811	Arp2/3 complex	DANRE|ZFIN=ZDB-GENE-040120-7|UniProtKB=Q7ZWH4	Actin-related protein 2/3 complex subunit 5	TAS	12473693	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IC	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CHICK|Ensembl=ENSGALG00000014268|UniProtKB=Q9PTS8	Neuronal acetylcholine receptor subunit alpha-9	IC			PTHR18945:SF489	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-9
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IDA	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00557	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IGI	7937853	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MACMU|Ensembl=ENSMMUG00000009287|UniProtKB=F7H3T9	Glutamate receptor 1 isoform 1	ISS	12941441	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00036	Interleukin signaling pathway	P00996	STAT	MONDO|Ensembl=ENSMODG00000028212|UniProtKB=F7BYN4	Signal transducer and activator of transcription	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00021	FGF signaling pathway	P00633	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P04398	p53 pathway feedback loops 2	P04665	AKT	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00045	Notch signaling pathway	P01103	Next	MACMU|Ensembl=ENSMMUG00000018375|UniProtKB=F7H1D5	Neurogenic locus notch homolog protein 2 isoform 1 preproprotein	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00865	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00015	Circadian clock system	G01499	per	DROME|FlyBase=FBgn0003068|UniProtKB=P07663	Period circadian protein	IDA	574095	PubMed	PTHR11269:SF16	PERIOD CIRCADIAN PROTEIN
P00036	Interleukin signaling pathway	P00996	STAT	MONDO|Ensembl=ENSMODG00000028212|UniProtKB=F7BYN4	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MOUSE|MGI=MGI=1915153|UniProtKB=Q9CX84	Regulator of G-protein signaling 19	IDA	8756726	PubMed	PTHR10845:SF145	REGULATOR OF G-PROTEIN SIGNALING 19
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=1759|UniProtKB=P19022	Cadherin-2	ISS	13678586	PubMed	PTHR24027:SF79	CADHERIN-2
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02781	Threonine biosynthesis	P03189	Aspartate kinase	YEAST|SGD=S000003900|UniProtKB=P31116	Homoserine dehydrogenase	ISS			PTHR43070:SF3	HOMOSERINE DEHYDROGENASE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	15621031	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00021	FGF signaling pathway	P00646	RasGAP	MACMU|Ensembl=ENSMMUG00000009418|UniProtKB=F6X9K0	Uncharacterized protein	ISS	20475167	gi	PTHR10194:SF21	RAS GTPASE-ACTIVATING PROTEIN 2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MOUSE|MGI=MGI=87902|UniProtKB=P68134	Actin, alpha skeletal muscle	ISS	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IDA	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	MACMU|Ensembl=ENSMMUG00000004657|UniProtKB=G7MVY8	Furin	ISS	95328031	PubMed	PTHR42884:SF1	FURIN
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04393	Ras Pathway	P04547	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00060	Ubiquitin proteasome pathway	P01491	E2	PHYPA|Gene=PHYPADRAFT_183918|UniProtKB=A9SDW9	Predicted protein	ISS			PTHR24068:SF55	UBIQUITIN-CONJUGATING ENZYME E2 11-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P06959	CCKR signaling map	P07218	FAK2	HUMAN|HGNC=9612|UniProtKB=Q14289	Protein-tyrosine kinase 2-beta	RCA	10329689	PubMed	PTHR24418:SF94	PROTEIN-TYROSINE KINASE 2-BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00367	NFAT	RAT|RGD=1310749|UniProtKB=D3Z9H7	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	ISS	12015605	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	RAT|RGD=621463|UniProtKB=G3V819	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00005	Angiogenesis	P00189	Fzd	DANRE|ZFIN=ZDB-GENE-000328-4|UniProtKB=B0S6S2	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF90	FRIZZLED-8
P00021	FGF signaling pathway	P00634	MEKK1-5	MACMU|Ensembl=ENSMMUG00000016376|UniProtKB=F7G2W1	Uncharacterized protein	ISS	11730323	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	DROME|FlyBase=FBgn0014342|UniProtKB=Q9VND0	Meiosis I arrest, isoform A	ISS			PTHR10221:SF12	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6
P00057	Wnt signaling pathway	P01457	GBeta	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01322	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	IGI	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00053	T cell activation	P01312	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IDA	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00019	Endothelin signaling pathway	P00571	Pro ET1-4	MACMU|Ensembl=ENSMMUG00000007263|UniProtKB=F7FGG2	Preproendothelin-1	ISS	15117818	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MACMU|Ensembl=ENSMMUG00000013433|UniProtKB=F6YVR2	Uncharacterized protein	ISS			PTHR22692:SF16	PROTEIN MYO15B
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P02775	Salvage pyrimidine ribonucleotides	P03151	Uracil phosphoribosyl  transferase	ANOGA|EnsemblGenome=AGAP007111|UniProtKB=Q7QIX0	AGAP007111-PA	ISS			PTHR10285:SF90	URACIL PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P06959	CCKR signaling map	P07121	MAP2K2	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	RCA	12239223	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00006	Apoptosis signaling pathway	P00269	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00807	Actin	MOUSE|MGI=MGI=87905|UniProtKB=P68033	Actin, alpha cardiac muscle 1	IDA	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	MOUSE|MGI=MGI=1338883|UniProtKB=Q9Z2Z9	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2	ISS			PTHR10937:SF10	GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE  ISOMERIZING  2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	RAT|RGD=62042|UniProtKB=O08835	Synaptotagmin-11	RCA			PTHR10024:SF115	SYNAPTOTAGMIN-11
P00036	Interleukin signaling pathway	P00983	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00029	Huntington disease	P00775	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	TAS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00057	Wnt signaling pathway	P01427	Naked	MOUSE|MGI=MGI=2135954|UniProtKB=Q99MH6	Protein naked cuticle homolog 1	IDA	11356022	PubMed	PTHR22611:SF2	PROTEIN NAKED CUTICLE HOMOLOG 1
P00005	Angiogenesis	P00226	Delta/Serrate	DANRE|ZFIN=ZDB-GENE-990415-47|UniProtKB=Q8UWJ4	Delta-like protein D	ISS	12361969	PubMed	PTHR24044:SF380	DELTA-LIKE PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DROME|FlyBase=FBgn0015765|UniProtKB=O62618	Mitogen-activated protein kinase 14A	IDA	9417090	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00034	Integrin signalling pathway	P00910	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	12748278	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00005	Angiogenesis	P00182	p38MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00049	Parkinson disease	P01213	Cyclin E	MOUSE|MGI=MGI=88316|UniProtKB=Q61457	G1/S-specific cyclin-E1	ISS	6671698	gi	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P02742	Tetrahydrofolate biosynthesis	P02941	Dihydroneopterin aldolase	ARATH|TAIR=AT3G21730|UniProtKB=Q6GKX5	Probable dihydroneopterin aldolase 3	ISS			PTHR42844:SF4	DIHYDRONEOPTERIN ALDOLASE 1-RELATED
P00005	Angiogenesis	P00238	Ras	ANOGA|EnsemblGenome=AGAP002219|UniProtKB=Q7QK91	AGAP002219-PA	ISS			PTHR24070:SF385	GTPASE HRAS
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	PANTR|Ensembl=ENSPTRG00000019161|UniProtKB=H2QUJ4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00624	14-3-3	ORNAN|Ensembl=ENSOANG00000003572|UniProtKB=F7DGH9	Uncharacterized protein	ISS	14593000	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	PANTR|Ensembl=ENSPTRG00000006175|UniProtKB=H2R2N7	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF721	MYOSIN-6
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	TAS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00036	Interleukin signaling pathway	P00968	Ikk	HUMAN|HGNC=1974|UniProtKB=O15111	Inhibitor of nuclear factor kappa-B kinase subunit alpha	IC	12235208	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000012822|UniProtKB=F6PX40	Phosphoinositide phospholipase C	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	MONDO|Ensembl=ENSMODG00000010107|UniProtKB=F6X4I0	Clathrin heavy chain	ISS	9388255	PubMed	PTHR10292:SF6	CLATHRIN HEAVY CHAIN 2
P06216	SCW signaling pathway	P06321	LACK	DROME|FlyBase=FBgn0029006|UniProtKB=Q9V853	E3 ubiquitin-protein ligase Smurf1	IEA	http://flybase.org/reports/FBgn0029006.html	Website	PTHR11254:SF395	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P00048	PI3 kinase pathway	P01192	p110	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00020	FAS signaling pathway	P00615	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_115565|UniProtKB=C3XYD3	Putative uncharacterized protein	ISS			PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00049	Parkinson disease	P01238	14-3-3	MOUSE|MGI=MGI=891963|UniProtKB=P68254	14-3-3 protein theta	IDA	9211421	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	RAT|RGD=620351|UniProtKB=P18265	Glycogen synthase kinase-3 alpha	IDA	11995474	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P04398	p53 pathway feedback loops 2	P04660	SIAH-1	MACMU|Ensembl=ENSMMUG00000007400|UniProtKB=F6T3K3	E3 ubiquitin-protein ligase	ISS	11389839	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=107434|UniProtKB=P97291	Cadherin-8	IDA	8120095	PubMed	PTHR24027:SF273	CADHERIN-8
P05731	GABA-B receptor II signaling	P05752	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00011	Blood coagulation	P00411	PAI-1	BOVIN|Ensembl=ENSBTAG00000014465|UniProtKB=P13909	Plasminogen activator inhibitor 1	ISS	3183108	gi	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00006	Apoptosis signaling pathway	P00269	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00543	ERK1-2	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	9298898	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	BOVIN|Ensembl=ENSBTAG00000007599|UniProtKB=Q95KV0	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	CANLF|Ensembl=ENSCAFG00000001738|UniProtKB=E2RDG9	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00010	B cell activation	P00373	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IGI	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05940	GRK5	MONDO|Ensembl=ENSMODG00000009266|UniProtKB=F7DA21	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF27	G PROTEIN-COUPLED RECEPTOR KINASE 5
P05918	p38 MAPK pathway	P06029	p38beta	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	RCA	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00034	Integrin signalling pathway	P00949	Shc	MOUSE|MGI=MGI=98296|UniProtKB=P98083	SHC-transforming protein 1	IPI	7798194	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MOUSE|MGI=MGI=87917|UniProtKB=Q01341	Adenylate cyclase type 6	IGI	92357702	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00047	PDGF signaling pathway	P01143	ERK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00924	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P02746	Heme biosynthesis	P02979	porphobilinogen synthase	FUSNN|EnsemblGenome=FN0460|UniProtKB=Q8RG58	Delta-aminolevulinic acid dehydratase	ISS			PTHR11458:SF0	DELTA-AMINOLEVULINIC ACID DEHYDRATASE
P04397	p53 pathway by glucose deprivation	P04640	p53	BOVIN|Ensembl=ENSBTAG00000005812|UniProtKB=G3X6J7	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00019	Endothelin signaling pathway	P00591	PLCbeta	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04565	MKK4/7	PANTR|Ensembl=ENSPTRG00000008783|UniProtKB=H2QCA7	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	PANTR|Ensembl=ENSPTRG00000012514|UniProtKB=H2QIT0	Serine/threonine-protein kinase receptor	ISS	9395284	PubMed	PTHR23255:SF64	ACTIVIN RECEPTOR TYPE-2A
P00018	EGF receptor signaling pathway	P00551	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IGI	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01227	20S proteasome	YEAST|SGD=S000005398|UniProtKB=P40303	Proteasome subunit alpha type-4	TAS	12859888	PubMed	PTHR11599:SF15	PROTEASOME SUBUNIT ALPHA TYPE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	XENTR|Xenbase=XB-GENE-491618|UniProtKB=Q6P378	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IC	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00038	JAK/STAT signaling pathway	P01027	STAT	CHICK|Ensembl=ENSGALG00000003282|UniProtKB=O93378	Signal transducer and activator of transcription	ISS	20119183	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DROME|FlyBase=FBgn0024980|UniProtKB=Q7KVY7	Syntaxin-4	IC			PTHR19957:SF19	SYNTAXIN-4
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	TAS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CAEEL|WormBase=WBGene00006371|UniProtKB=Q20024	Putative syntaxin-3	IC			PTHR19957:SF41	SYNTAXIN-1A
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00056	VEGF signaling pathway	P01411	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	DANRE|ZFIN=ZDB-GENE-040120-7|UniProtKB=Q7ZWH4	Actin-related protein 2/3 complex subunit 5	ISS	12932731	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00018	EGF receptor signaling pathway	P00552	Ras	MONDO|Ensembl=ENSMODG00000025248|UniProtKB=F7F5X1	Uncharacterized protein	ISS	9869449	PubMed	PTHR24070:SF186	GTPASE KRAS
P05731	GABA-B receptor II signaling	P05754	Ggamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00195	APC	DROME|FlyBase=FBgn0026598|UniProtKB=Q9Y1T2	Adenomatous polyposis coli 2	ISS			PTHR12607:SF12	APC-LIKE, ISOFORM A-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	IC	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	STRCO|Gene=CAB89449|UniProtKB=Q9KZ71	Putative cystathionine beta-synthase	ISS			PTHR10314:SF8	CYSTATHIONINE BETA-SYNTHASE-RELATED
P02730	Asparagine and aspartate biosynthesis	P02853	Asparagine synthetase	METJA|EnsemblGenome=MJ_1056|UniProtKB=Q58456	Putative asparagine synthetase [glutamine-hydrolyzing] 2	ISS			PTHR43284:SF2	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00256	PLC-gamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	ENTHI|EnsemblGenome=EHI_110180|UniProtKB=C4LU72	Myosin heavy chain	IC			PTHR13140:SF667	MYOSIN-J HEAVY CHAIN
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00034	Integrin signalling pathway	P00907	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	SYNY3|EnsemblGenome=BAA10403|UniProtKB=Q55756	Carbamoyl-phosphate synthase large chain	ISS			PTHR11405:SF5	CAD PROTEIN
P00010	B cell activation	P00373	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IGI	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	RCA	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	PANTR|Ensembl=ENSPTRG00000039101|UniProtKB=H2RFN4	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR15936:SF2	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-13
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DANRE|ZFIN=ZDB-GENE-010705-1|UniProtKB=Q90Z40	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IDA	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01174	Rho	MACMU|Ensembl=ENSMMUG00000001952|UniProtKB=F6VHC8	Uncharacterized protein	ISS			PTHR14166:SF15	SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	ANOGA|EnsemblGenome=AGAP001394|UniProtKB=F5HMS4	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00057	Wnt signaling pathway	P01451	Galpha	MOUSE|MGI=MGI=95770|UniProtKB=P30678	Guanine nucleotide-binding protein subunit alpha-15	IDA	8838318	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00023	General transcription regulation	P00669	TFIIEalpha	MACMU|Ensembl=ENSMMUG00000001596|UniProtKB=F7GV34	General transcription factor IIE subunit 1	ISS	189964	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00036	Interleukin signaling pathway	P00989	Ets	CHICK|Ensembl=ENSGALG00000008127|UniProtKB=E1BZN0	Uncharacterized protein	ISS	8970723	PubMed	PTHR11849:SF16	TRANSCRIPTION FACTOR PU.1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00056	VEGF signaling pathway	P01407	Erk	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	7925653	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01174	Rho	MOUSE|MGI=MGI=1332637|UniProtKB=P97393	Rho GTPase-activating protein 5	ISS			PTHR15377:SF4	RHO GTPASE-ACTIVATING PROTEIN 5
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	DROME|FlyBase=FBgn0003889|UniProtKB=P61857	Tubulin beta-2 chain	ISS	12932731	PubMed	PTHR11588:SF155	TUBULIN BETA-2 CHAIN
P00059	p53 pathway	G04694	p110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00796	Kainate receptor	CHICK|Ensembl=ENSGALG00000015835|UniProtKB=F1NZT2	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DROME|FlyBase=FBgn0024846|UniProtKB=O61443	Mitogen-activated protein kinase 14B	IDA	11274345	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	TAS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IDA	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01173	STAT	MACMU|Ensembl=ENSMMUG00000010705|UniProtKB=F7G8V4	Signal transducer and activator of transcription	ISS	14662325	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00036	Interleukin signaling pathway	P00976	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00015	Circadian clock system	G01501	cry	CANLF|Ensembl=ENSCAFG00000001797|UniProtKB=E2RMX4	Uncharacterized protein	ISS	10217146	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	MACMU|Ensembl=ENSMMUG00000001060|UniProtKB=F6QN17	Uncharacterized protein	ISS	15226293	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00131	HAC1	PANTR|Ensembl=ENSPTRG00000003290|UniProtKB=H2R2V6	Tripartite motif-containing 3	ISS			PTHR44028:SF1	TRIPARTITE MOTIF-CONTAINING PROTEIN 3
P00049	Parkinson disease	P01230	Src kinase	HUMAN|HGNC=12841|UniProtKB=P07947	Tyrosine-protein kinase Yes	IDA	11078745	PubMed	PTHR24418:SF90	TYROSINE-PROTEIN KINASE YES
P00022	General transcription by RNA polymerase I	P00657	TBP	METAC|EnsemblGenome=MA_0179|UniProtKB=Q8TU94	TATA-box-binding protein 2	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	TAS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	RAT|RGD=1303097|UniProtKB=Q4KMC4	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2	ISS			PTHR10937:SF10	GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE  ISOMERIZING  2
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00219	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00049	Parkinson disease	P01230	Src kinase	RAT|RGD=2641|UniProtKB=Q62844	Tyrosine-protein kinase Fyn	IDA	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00052	TGF-beta signaling pathway	P01286	TGFbeta	HUMAN|HGNC=4216|UniProtKB=O95390	Growth/differentiation factor 11	TAS	9759503	PubMed	PTHR11848:SF166	GROWTH/DIFFERENTIATION FACTOR 11
P02751	Lysine biosynthesis	P03006	Dihydrodipicolinate  reductase	RHOBA|EnsemblGenome=RB11959|UniProtKB=Q7UJD7	4-hydroxy-tetrahydrodipicolinate reductase	ISS			PTHR20836:SF0	DIHYDRODIPICOLINATE REDUCTASE-LIKE PROTEIN CRR1, CHLOROPLASTIC
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00029	Huntington disease	G01530	HTT	CANLF|Ensembl=ENSCAFG00000014682|UniProtKB=F1P7Y7	Uncharacterized protein	ISS	8268927	PubMed	PTHR10170:SF10	HUNTINGTIN
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	IDA	12885769	PubMed	PTHR10202:SF13	PRESENILIN-2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	TAS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00025	Hedgehog signaling pathway	P00692	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00053	T cell activation	P01322	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	IGI	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	TAS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MOUSE|MGI=MGI=109356|UniProtKB=O09044	Synaptosomal-associated protein 23	IC	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00021	FGF signaling pathway	P00644	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00048	PI3 kinase pathway	G01546	Cyclin d	MOUSE|MGI=MGI=88313|UniProtKB=P25322	G1/S-specific cyclin-D1	ISS	12356903	PubMed	PTHR10177:SF67	G1/S-SPECIFIC CYCLIN-D1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	RAT|RGD=61897|UniProtKB=P46002	Platelet-activating factor receptor	ISS	12038971	PubMed	PTHR24233:SF6	PLATELET-ACTIVATING FACTOR RECEPTOR
P00018	EGF receptor signaling pathway	P00562	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06841	gnaq/11	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	RCA	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04376	5HT4 type receptor mediated signaling pathway	P04427	5HT4 Receptor	MOUSE|MGI=MGI=109246|UniProtKB=P97288	5-hydroxytryptamine receptor 4	ISS	12898568	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P00048	PI3 kinase pathway	P01198	FOXO	PANTR|Ensembl=ENSPTRG00000005806|UniProtKB=H2Q7G4	Uncharacterized protein	ISS	10347145	PubMed	PTHR11829:SF159	FORKHEAD BOX PROTEIN O1
P02752	Mannose metabolism	P03017	Mannose 6-P isomerase	CANAL|CGD=CAL0000189115|UniProtKB=P34948	Mannose-6-phosphate isomerase	ISS	7785330	PubMed	PTHR10309:SF0	MANNOSE-6-PHOSPHATE ISOMERASE
P00018	EGF receptor signaling pathway	P00547	PP2A	PANTR|Ensembl=ENSPTRG00000003853|UniProtKB=H2Q411	Protein phosphatase 2, regulatory subunit B', beta	ISS	11531413	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	BOVIN|Ensembl=ENSBTAG00000047062|UniProtKB=G3MX13	Uncharacterized protein	ISS	11907044	PubMed	PTHR44062:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 3
P04393	Ras Pathway	P04570	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MOUSE|MGI=MGI=1309999|UniProtKB=Q922R0	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00006	Apoptosis signaling pathway	P00259	TNF	RAT|RGD=3020|UniProtKB=Q06332	Lymphotoxin-alpha	ISS	9862717	PubMed	PTHR11471:SF31	LYMPHOTOXIN-ALPHA
P05916	Opioid prodynorphin pathway	P06002	G-protein	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Gene=HTR1E|UniProtKB=Q9N2B6	5-hydroxytryptamine receptor 1E (Fragment)	ISS	12181435	PubMed	PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	XENTR|Xenbase=XB-GENE-487200|UniProtKB=Q28GC2	Catenin (Cadherin associated protein), beta 1, 88kDa	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P04393	Ras Pathway	P04547	Ras	CAEEL|WormBase=WBGene00002335|UniProtKB=P22981	Ras protein let-60	IDA	12024031	PubMed	PTHR24070:SF385	GTPASE HRAS
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	SCHPO|PomBase=SPBC2D10.14c|UniProtKB=O74805	Myosin-51	IC			PTHR13140:SF725	DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00748	Gbeta5L	HUMAN|HGNC=4401|UniProtKB=O14775	Guanine nucleotide-binding protein subunit beta-5	IDA	9754712	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00056	VEGF signaling pathway	P01407	Erk	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00558	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02766	Phenylethylamine degradation	P03102	Phenylacetaldehyde dehydrogenase	ECOLI|EcoGene=EG13179|UniProtKB=P80668	Phenylacetaldehyde dehydrogenase	ISS	14724059	PubMed	PTHR11699:SF222	PHENYLACETALDEHYDE DEHYDROGENASE
P00047	PDGF signaling pathway	P01161	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P06959	CCKR signaling map	G06990	MOB1	HUMAN|HGNC=16015|UniProtKB=Q9H8S9	MOB kinase activator 1A	RCA	10666030	PubMed	PTHR22599:SF30	MOB KINASE ACTIVATOR 1A
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	TAS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00054	Toll receptor signaling pathway	P01375	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04391	Oxytocin receptor mediated signaling pathway	P04531	Oxytocin Receptor	RAT|RGD=3239|UniProtKB=P70536	Oxytocin receptor	ISS	11006161	PubMed	PTHR24241:SF19	OXYTOCIN RECEPTOR
P00006	Apoptosis signaling pathway	P00274	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00029	Huntington disease	P00778	NMDA receptor	MACMU|Ensembl=ENSMMUG00000019112|UniProtKB=F6T8S6	N-methyl D-aspartate receptor subtype 2B	ISS	11554554	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	TAS	9851932	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	IDA	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008018|UniProtKB=F7EPG4	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	HUMAN|HGNC=8592|UniProtKB=O75914	Serine/threonine-protein kinase PAK 3	ISS	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00056	VEGF signaling pathway	P01411	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00056	VEGF signaling pathway	P01409	cPLA2	RAT|RGD=67366|UniProtKB=P50393	Cytosolic phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	HUMAN|HGNC=235|UniProtKB=Q8NFM4	Adenylate cyclase type 4	ISS	9870949	PubMed	PTHR11920:SF286	ADENYLATE CYCLASE TYPE 4
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BOVIN|Gene=ACTR2|UniProtKB=A7MB62	Actin-related protein 2	ISS	10974003	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00018	EGF receptor signaling pathway	P00547	PP2A	CHICK|Ensembl=ENSGALG00000010273|UniProtKB=P48463	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	IGI	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	BOVIN|Ensembl=ENSBTAG00000016797|UniProtKB=A7MB90	CSNK1G2 protein	ISS	10617630	PubMed	PTHR11909:SF157	CASEIN KINASE I ISOFORM GAMMA-2
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	MONDO|Ensembl=ENSMODG00000019001|UniProtKB=F7CP86	Serine/threonine-protein phosphatase	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00845	Cyclooxygenase	PANTR|Ensembl=ENSPTRG00000021325|UniProtKB=H2R6C5	Uncharacterized protein	ISS	10668482	PubMed	PTHR11903:SF6	PROSTAGLANDIN G/H SYNTHASE 1
P00048	PI3 kinase pathway	P01185	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	CHLTR|EnsemblGenome=CT_432|UniProtKB=O84439	Serine hydroxymethyltransferase	ISS			PTHR11680:SF21	SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC
P05918	p38 MAPK pathway	P06031	p38alpha	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MOUSE|MGI=MGI=95777|UniProtKB=Q6R0H7	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	MACMU|Ensembl=ENSMMUG00000012305|UniProtKB=F7DLC9	Tyrosine-protein kinase receptor	ISS	11182407	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MACMU|Ensembl=ENSMMUG00000012054|UniProtKB=F6TII3	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00006	Apoptosis signaling pathway	P00282	IGFR2	MOUSE|MGI=MGI=96435|UniProtKB=Q07113	Cation-independent mannose-6-phosphate receptor	IDA	11081635	PubMed	PTHR15071:SF17	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MOUSE|MGI=MGI=98329|UniProtKB=P30935	Somatostatin receptor type 3	IDA			PTHR24229:SF42	SOMATOSTATIN RECEPTOR TYPE 3
P00054	Toll receptor signaling pathway	P01352	p38	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00018	EGF receptor signaling pathway	P00547	PP2A	MACMU|Ensembl=ENSMMUG00000020819|UniProtKB=F7HSM1	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00004	Alzheimer disease-presenilin pathway	P00153	gammacatenin	HUMAN|HGNC=6207|UniProtKB=P14923	Junction plakoglobin	IDA	9172160	PubMed	PTHR23315:SF12	JUNCTION PLAKOGLOBIN
P00034	Integrin signalling pathway	P00925	MEK	DROME|FlyBase=FBgn0024326|UniProtKB=O61444	MAP kinase kinase 4, isoform A	IDA	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00049	Parkinson disease	P01238	14-3-3	PANTR|Ensembl=ENSPTRG00000030723|UniProtKB=H2RC87	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF14	14-3-3 PROTEIN SIGMA
P00047	PDGF signaling pathway	P01153	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	TAKRU|Ensembl=ENSTRUG00000016101|UniProtKB=H2UW32	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00006	Apoptosis signaling pathway	P00269	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P02734	Chorismate biosynthesis	P02868	Chorismate synthase	DEIRA|EnsemblGenome=DR_0775|UniProtKB=Q9RW94	Chorismate synthase	ISS			PTHR21085:SF0	CHORISMATE SYNTHASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MACMU|Ensembl=ENSMMUG00000010729|UniProtKB=F7G4Y1	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF26	REGULATOR OF G-PROTEIN SIGNALING 7
P00006	Apoptosis signaling pathway	P00260	AKT	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00962	ELK	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	IC	11050086	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Gene=PLCD4|UniProtKB=P21671	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	7822322	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MOUSE|MGI=MGI=108408|UniProtKB=Q8BXT1	Regulator of G-protein signaling 8	ISS	8756726	PubMed	PTHR10845:SF147	REGULATOR OF G-PROTEIN SIGNALING 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MOUSE|MGI=MGI=2152453|UniProtKB=Q2NL51	Glycogen synthase kinase-3 alpha	ISS	12086949	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00018	EGF receptor signaling pathway	P00539	14-3-3	CHICK|Ensembl=ENSGALG00000010725|UniProtKB=Q5ZKC9	14-3-3 protein zeta	ISS	12615066	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P04398	p53 pathway feedback loops 2	P04657	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MOUSE|MGI=MGI=99675|UniProtKB=Q8VHH7	Adenylate cyclase type 3	ISS	2255909	PubMed	PTHR11920:SF291	ADENYLATE CYCLASE TYPE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	ANOGA|EnsemblGenome=AGAP000966|UniProtKB=Q7QI10	AGAP000966-PA	IC	22213672	PubMed	PTHR18945:SF771	ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02724	Alanine biosynthesis	P02815	Branched chain amino acid aminotransferase	BACSU|EnsemblGenome=BSU02390|UniProtKB=O31461	Branched-chain-amino-acid transaminase 1	ISS			PTHR11825:SF44	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00048	PI3 kinase pathway	P01199	Galpha	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	IC	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00056	VEGF signaling pathway	P01411	Ras	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00057	Wnt signaling pathway	P01427	Naked	PANTR|Ensembl=ENSPTRG00000008104|UniProtKB=H2RA69	Uncharacterized protein	ISS	11356022	PubMed	PTHR22611:SF2	PROTEIN NAKED CUTICLE HOMOLOG 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00057	Wnt signaling pathway	P01437	TCF	XENTR|Xenbase=XB-GENE-1031985|UniProtKB=Q6GL68	Transcription factor 7-like 1	ISS	12356903	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	HUMAN|HGNC=1957|UniProtKB=P32297	Neuronal acetylcholine receptor subunit alpha-3	ISS	85270494	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P04393	Ras Pathway	P04542	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00008	Axon guidance mediated by Slit/Robo	P00344	Netrin	PANTR|Ensembl=ENSPTRG00000008752|UniProtKB=H2QC90	Uncharacterized protein	ISS	11356879	PubMed	PTHR10574:SF365	NETRIN-1
P00046	Oxidative stress response	P01129	JNK1/2	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00021	FGF signaling pathway	P00647	SHP2	MACMU|Ensembl=ENSMMUG00000013253|UniProtKB=F6ZJD8	Tyrosine-protein phosphatase non-receptor type	ISS	1382983	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00047	PDGF signaling pathway	P01152	RasGAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	8262392	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	TAS	14526383	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00053	T cell activation	P01312	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	XENTR|Xenbase=XB-GENE-483058|UniProtKB=Q90YD6	BMP4	ISS	9759503	PubMed	PTHR11848:SF165	BONE MORPHOGENETIC PROTEIN 4
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	TAS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00010	B cell activation	P00383	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IDA	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	PANTR|Ensembl=ENSPTRG00000015681|UniProtKB=H2QNU7	Dishevelled, dsh homolog 3	ISS	10409711	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P00041	Metabotropic glutamate receptor group I pathway	P01062	mGluR1	MACMU|Ensembl=ENSMMUG00000016428|UniProtKB=F7GU00	Metabotropic glutamate receptor 1 isoform alpha	ISS	7476890	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95774|UniProtKB=Q8CGK7	Guanine nucleotide-binding protein G(olf) subunit alpha	IC	2106672	PubMed	PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01275	P38	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	TAS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00019	Endothelin signaling pathway	P00589	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05918	p38 MAPK pathway	P06025	SRF	MACMU|Ensembl=ENSMMUG00000000033|UniProtKB=F7G4D2	Uncharacterized protein	ISS	8660892	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00048	PI3 kinase pathway	P01202	p85	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05734	Synaptic vesicle trafficking	P05779	Synaptobrevin	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00059	p53 pathway	P04609	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00053	T cell activation	P01335	jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00938	Cdc42	HUMAN|HGNC=1736|UniProtKB=P60953	Cell division control protein 42 homolog	IDA	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00053	T cell activation	P01316	MHC-antigen	MOUSE|MGI=MGI=95895|UniProtKB=P01910	H-2 class II histocompatibility antigen, A-K alpha chain	IPI	73139	PubMed	PTHR19944:SF59	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DQ ALPHA 1 CHAIN
P06212	DPP-SCW signaling pathway	P06265	MED	DROME|FlyBase=FBgn0011655|UniProtKB=O62609	Mothers against decapentaplegic homolog	IEA	http://flybase.org/reports/FBgn0011655.html	Website	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P00013	Cell cycle	P00480	Proteasome	NEUCR|EnsemblGenome=EFNCRG00000001796|UniProtKB=Q8WZY4	26S proteasome regulatory subunit rpn-8	NAS	18376158	gi	PTHR10540:SF7	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7
P02738	De novo purine biosynthesis	P02909	GDP reductase	YEAST|SGD=S000000872|UniProtKB=P21524	Ribonucleoside-diphosphate reductase large chain 1	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00035	Interferon-gamma signaling pathway	P00961	STAT1	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	14984365	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	PANTR|Ensembl=ENSPTRG00000016891|UniProtKB=H2R5K3	Uncharacterized protein	ISS	12168099	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02738	De novo purine biosynthesis	P02902	ADP reductase	CAEEL|WormBase=WBGene00004392|UniProtKB=P42170	Ribonucleoside-diphosphate reductase small chain	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	RCA			PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05913	Enkephalin release	P05974	G-Protein (i)	CAEEL|WormBase=WBGene00001648|UniProtKB=P51875	Guanine nucleotide-binding protein G(o) subunit alpha	IC	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	RAT|RGD=1308423|UniProtKB=D3ZY89	Protein Taf8	ISS	604904	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00041	Metabotropic glutamate receptor group I pathway	P01062	mGluR1	HUMAN|HGNC=4593|UniProtKB=Q13255	Metabotropic glutamate receptor 1	ISS	7476890	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00059	p53 pathway	P04609	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	BOVIN|Ensembl=ENSBTAG00000016198|UniProtKB=E1B8D6	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00012	Cadherin signaling pathway	P00474	Wnt	DANRE|ZFIN=ZDB-GENE-980526-416|UniProtKB=Q92048	Protein Wnt-2	IDA	11266476	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00029	Huntington disease	P00807	Actin	PANTR|Ensembl=ENSPTRG00000002086|UniProtKB=H2Q1A9	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MOUSE|MGI=MGI=1913316|UniProtKB=P61953	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	ISS	2122451	PubMed	PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01080	AChE	MOUSE|MGI=MGI=87876|UniProtKB=P21836	Acetylcholinesterase	IC			PTHR43918:SF3	ACETYLCHOLINESTERASE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04393	Ras Pathway	P04542	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00564	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12874273	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P06959	CCKR signaling map	P07225	RAC1-GDP	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	RCA	18565785	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PANTR|Ensembl=ENSPTRG00000011990|UniProtKB=H2QHZ9	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P02733	Carnitine metabolism	P02866	Carnitine dehydratase	CAEEL|WormBase=WBGene00014128|UniProtKB=Q09618	CaiB/baiF CoA-transferase family protein ZK892.4	ISS			PTHR44134:SF1	ALPHA-METHYLACYL-COA RACEMASE
P04397	p53 pathway by glucose deprivation	P04641	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	BOVIN|Gene=ADCY1|UniProtKB=P19754	Adenylate cyclase type 1	IGI	2491850	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00897	SHIP2	CANLF|Ensembl=ENSCAFG00000005743|UniProtKB=F1PNY0	Uncharacterized protein	ISS	10610720	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P04393	Ras Pathway	P04552	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	PANTR|Ensembl=ENSPTRG00000009415|UniProtKB=H2QDG2	Nucleoside diphosphate kinase	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	HUMAN|HGNC=6026|UniProtKB=P25024	C-X-C chemokine receptor type 1	IPI	4504683	gi	PTHR10489:SF916	C-X-C CHEMOKINE RECEPTOR TYPE 1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=1913316|UniProtKB=P61953	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	ISS			PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P04393	Ras Pathway	P04557	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	IDA	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04393	Ras Pathway	P04542	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00213	FGF	RAT|RGD=2605|UniProtKB=P61149	Fibroblast growth factor 1	ISS	12095987	PubMed	PTHR11486:SF86	FIBROBLAST GROWTH FACTOR 1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MONDO|Ensembl=ENSMODG00000013079|UniProtKB=F7FB74	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	DANRE|ZFIN=ZDB-GENE-070524-2|UniProtKB=B6E506	Dopamine receptor D1	ISS	11248120	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00010	B cell activation	P00401	jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	12972619	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00021	FGF signaling pathway	P00647	SHP2	CAEEL|WormBase=WBGene00004214|UniProtKB=G5EC24	Tyrosine-protein phosphatase non-receptor type ptp-2	IGI			PTHR19134:SF428	TYROSINE-PROTEIN PHOSPHATASE CORKSCREW
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	XENTR|Xenbase=XB-GENE-487924|UniProtKB=F6WVD0	Casein kinase II subunit beta (Fragment)	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MACMU|Ensembl=ENSMMUG00000001661|UniProtKB=F7GR69	Uncharacterized protein	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00036	Interleukin signaling pathway	P00990	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	MOUSE|MGI=MGI=1349393|UniProtKB=P61219	DNA-directed RNA polymerases I, II, and III subunit RPABC2	ISS	12841771	gi	PTHR10773:SF12	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06850	PKCs(3)	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	RCA	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02738	De novo purine biosynthesis	P02905	Amidophosphoribosyl transferase	HUMAN|HGNC=9238|UniProtKB=Q06203	Amidophosphoribosyltransferase	ISS			PTHR11907:SF18	AMIDOPHOSPHORIBOSYLTRANSFERASE
P05916	Opioid prodynorphin pathway	P06002	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00029	Huntington disease	P00790	beta-Tubulin	DICPU|Gene=DICPUDRAFT_47166|UniProtKB=F0ZI20	Beta tubulin	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00057	Wnt signaling pathway	P01451	Galpha	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CAEBR|Gene=CBG23091|UniProtKB=A8Y4Q9	Protein CBR-ACT-2	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00060	Ubiquitin proteasome pathway	P01492	E1	PANTR|Ensembl=ENSPTRG00000011202|UniProtKB=G2HJS6	SUMO1 activating enzyme subunit 1	ISS			PTHR10953:SF162	SUMO-ACTIVATING ENZYME SUBUNIT 1
P00018	EGF receptor signaling pathway	P00547	PP2A	TAKRU|Ensembl=ENSTRUG00000008018|UniProtKB=H2T5N4	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00243	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01219	SAPK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00029	Huntington disease	P00805	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	YEAST|SGD=S000003174|UniProtKB=P22137	Clathrin heavy chain	IDA	9388255	PubMed	PTHR10292:SF1	CLATHRIN HEAVY CHAIN
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Gene=PCDHB5|UniProtKB=Q5DRC9	Protocadherin beta-5	ISS	8120095	PubMed	PTHR24028:SF90	PROTOCADHERIN BETA-5
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P05913	Enkephalin release	P05974	G-Protein (i)	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	IC	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	CAEBR|Gene=CBG02401|UniProtKB=A8WUE7	Protein CBR-NMR-1	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	TAS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IPI	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	BOVIN|Ensembl=ENSBTAG00000037985|UniProtKB=F1MCK3	Muscarinic acetylcholine receptor	ISS	10069496	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04609	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00642	MEK1-2	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	IC	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P02781	Threonine biosynthesis	P03190	Threonine synthase	ARATH|TAIR=AT1G72810|UniProtKB=Q9SSP5	Threonine synthase 2, chloroplastic	ISS			PTHR10314:SF158	THREONINE SYNTHASE 2, CHLOROPLASTIC
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	HUMAN|HGNC=3025|UniProtKB=P21917	D(4) dopamine receptor	ISS	12181435	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00006	Apoptosis signaling pathway	P00318	PKCs	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00005	Angiogenesis	P00190	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P02775	Salvage pyrimidine ribonucleotides	P03150	Uridine kinase	CAEBR|Gene=CBG03314|UniProtKB=A8WUR5	Uridine kinase	ISS			PTHR10285:SF123	URIDINE KINASE
P00019	Endothelin signaling pathway	P00589	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	IGI	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01192	p110	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05993	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	RAT|RGD=708450|UniProtKB=Q9Z286	Adenylate cyclase type 10	IGI	11744988	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P00029	Huntington disease	P00788	Calpain	MACMU|Ensembl=ENSMMUG00000015628|UniProtKB=F6RMD5	Uncharacterized protein	ISS	11675509	PubMed	PTHR10183:SF30	CALPAIN-10
P00052	TGF-beta signaling pathway	P01275	P38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	MACMU|Ensembl=ENSMMUG00000014807|UniProtKB=F6W548	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CANLF|Ensembl=ENSCAFG00000012181|UniProtKB=F2Z4N7	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00019	Endothelin signaling pathway	P00570	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04392	P53 pathway feedback loops 1	G04686	p73	BOVIN|Ensembl=ENSBTAG00000005812|UniProtKB=G3X6J7	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DANRE|ZFIN=ZDB-GENE-030131-172|UniProtKB=Q6IQR3	Actin, alpha, cardiac muscle 1a	IEP	11889139	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00035	Interferon-gamma signaling pathway	P00953	Jak1	PANTR|Ensembl=ENSPTRG00000000825|UniProtKB=H2PZ66	Tyrosine-protein kinase	ISS	9637709	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00010	B cell activation	P00381	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Ensembl=ENSBTAG00000007635|UniProtKB=F1MLS3	Phosphoinositide phospholipase C	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P00049	Parkinson disease	P01240	hSel10	CHICK|Ensembl=ENSGALG00000002229|UniProtKB=F1P5E8	Uncharacterized protein	ISS			PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00747	Rhodopsin	PANTR|Ensembl=ENSPTRG00000015379|UniProtKB=H2QNC5	Rhodopsin	ISS	1634520	PubMed	PTHR24240:SF15	RHODOPSIN
P02778	Sulfate assimilation	P03167	Sulfate adenylyltransferase	CANAL|CGD=CAL0000178072|UniProtKB=Q9Y872	Sulfate adenylyltransferase	ISS			PTHR42700:SF1	SULFATE ADENYLYLTRANSFERASE
P04393	Ras Pathway	P04541	p90RSK	BOVIN|Ensembl=ENSBTAG00000002015|UniProtKB=G5E5T2	Uncharacterized protein	ISS	15632195	PubMed	PTHR24351:SF98	RIBOSOMAL PROTEIN S6 KINASE ALPHA-6
P00010	B cell activation	P00372	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	7689150	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00005	Angiogenesis	P00211	GSK3beta	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	RAT|RGD=1308152|UniProtKB=Q5FVM5	Cyclic AMP-responsive element-binding protein 3-like protein 3	ISS	608986	OMIM	PTHR22952:SF98	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 3
P00025	Hedgehog signaling pathway	P00682	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P02783	Tryptophan biosynthesis	P03206	Anthranilate synthase	RHOBA|EnsemblGenome=RB3936|UniProtKB=Q7UTD9	Anthranilate synthase component II	RCA			PTHR43418:SF4	MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN
P00019	Endothelin signaling pathway	P00586	Gq	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00047	PDGF signaling pathway	P01157	MAPKAPK2	ORNAN|Ensembl=ENSOANG00000007737|UniProtKB=F6PX17	Uncharacterized protein	ISS			PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00048	PI3 kinase pathway	P01202	p85	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CAEEL|WormBase=WBGene00010545|UniProtKB=G5EBG3	CBP/p300 homolog	TAS	10769018	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	CAEEL|WormBase=WBGene00001746|UniProtKB=Q9U2Q9	Glycogen synthase kinase-3	ISS	21361340	gi	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	IC	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04570	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00034	Integrin signalling pathway	P00907	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	IDA	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00056	VEGF signaling pathway	P01425	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	10395542	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00018	EGF receptor signaling pathway	P00539	14-3-3	DANRE|ZFIN=ZDB-GENE-030131-779|UniProtKB=Q7ZW20	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1	ISS	12917326	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P06959	CCKR signaling map	P07103	PRKD1	HUMAN|HGNC=9407|UniProtKB=Q15139	Serine/threonine-protein kinase D1	RCA	17306383	PubMed	PTHR22968:SF9	SERINE/THREONINE-PROTEIN KINASE D1
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04398	p53 pathway feedback loops 2	P04651	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00006	Apoptosis signaling pathway	P00269	MAPK	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04393	Ras Pathway	P04556	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00462	Casein kinase II	BRAFL|Gene=BRAFLDRAFT_113587|UniProtKB=C3ZBE3	Putative uncharacterized protein	ISS	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00006	Apoptosis signaling pathway	P00274	JNK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT2G18170|UniProtKB=Q39027	Mitogen-activated protein kinase 7	ISS	10851062	PubMed	PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P00006	Apoptosis signaling pathway	P00272	ASK1	BOVIN|Ensembl=ENSBTAG00000009065|UniProtKB=F1MXH6	Uncharacterized protein	ISS	11730323	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00036	Interleukin signaling pathway	P00997	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	7798194	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P04393	Ras Pathway	P04565	MKK4/7	CANLF|Ensembl=ENSCAFG00000017851|UniProtKB=F1PBB6	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00005	Angiogenesis	P00216	Caspase 9	MOUSE|MGI=MGI=1277950|UniProtKB=Q8C3Q9	Caspase-9	ISS	9390557	PubMed	PTHR10454:SF157	CASPASE-9
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CAEBR|Gene=CBG05858|UniProtKB=A8X1H0	Protein CBR-EGL-19 (Fragment)	ISS	9199552	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00034	Integrin signalling pathway	P00944	Actin	BOVIN|Ensembl=ENSBTAG00000014614|UniProtKB=P62739	Actin, aortic smooth muscle	ISS	3487386	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00007	Axon guidance mediated by semaphorins	P00340	Rac	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS	12606638	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_56698|UniProtKB=C3XYC3	Putative uncharacterized protein	IDA	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P05913	Enkephalin release	P05975	GPCR (s)	MOUSE|MGI=MGI=97441|UniProtKB=P42866	Mu-type opioid receptor	ISS	11259498	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ORNAN|Ensembl=ENSOANG00000007405|UniProtKB=F7CIV4	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01153	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	TAS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g188243|UniProtKB=A7SCN8	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00024	Glycolysis	P00679	Aldolase	DANRE|ZFIN=ZDB-GENE-030821-1|UniProtKB=Q8JH70	Fructose-bisphosphate aldolase C-B	ISS	2828145	gi	PTHR11627:SF3	FRUCTOSE-BISPHOSPHATE ALDOLASE C
P00023	General transcription regulation	P00664	TFIIH complex	YEAST|SGD=S000006043|UniProtKB=Q02939	RNA polymerase II transcription factor B subunit 2	ISS			PTHR13152:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00038	JAK/STAT signaling pathway	P01027	STAT	CANLF|Ensembl=ENSCAFG00000015509|UniProtKB=F1PNW8	Signal transducer and activator of transcription	ISS	8732682	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	BRAFL|Gene=BRAFLDRAFT_115565|UniProtKB=C3XYD3	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00057	Wnt signaling pathway	P01465	Ggamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IGI	9516481	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00056	VEGF signaling pathway	P01407	Erk	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00591	PLCbeta	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04398	p53 pathway feedback loops 2	P04651	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00019	Endothelin signaling pathway	P00591	PLCbeta	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	CHICK|Gene=ACVR2B|UniProtKB=Q90670	Activin receptor type-2B	TAS	9395284	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00036	Interleukin signaling pathway	P00964	p90RSK	RAT|RGD=1563860|UniProtKB=D3Z8E0	Ribosomal protein S6 kinase	ISS	10480933	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000014675|UniProtKB=H2QM57	Phosphoinositide phospholipase C	ISS			PTHR10336:SF84	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	STRCO|Gene=CAA16198|UniProtKB=O54170	Aminotransferase	ISS			PTHR43795:SF24	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05913	Enkephalin release	P05972	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	TAKRU|Ensembl=ENSTRUG00000006307|UniProtKB=H2SSM1	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00023	General transcription regulation	P00658	TBP-associated factors	RAT|RGD=1308423|UniProtKB=D3ZY89	Protein Taf8	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00021	FGF signaling pathway	P00631	Grb2	CAEBR|Gene=CBG16856|UniProtKB=A8XPY6	Protein CBR-SEM-5	ISS	51702266	gi	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00005	Angiogenesis	P00193	SOS-1	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02752	Mannose metabolism	P03015	GDP-Mannose 4,6-dehydratase	BRADU|Gene=BAC46896|UniProtKB=Q89TZ1	GDP-mannose 4,6-dehydratase	ISS	12642192	gi	PTHR43715:SF1	GDP-MANNOSE 4,6 DEHYDRATASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	TRIVA|Gene=TVAG_090470|UniProtKB=A2FA04	Actin	IDA			PTHR11937:SF155	ACTIN-5C-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	TAS	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01153	GSK3	RAT|RGD=620351|UniProtKB=P18265	Glycogen synthase kinase-3 alpha	ISS	183955	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-040426-2427|UniProtKB=F1Q6C0	Uncharacterized protein (Fragment)	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DANRE|ZFIN=ZDB-GENE-050410-4|UniProtKB=Q56A35	Actin-related protein 2-B	ISS	10974003	PubMed	PTHR11937:SF149	ACTIN-RELATED PROTEIN 2-A-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01067	AChE	PANTR|Ensembl=ENSPTRG00000019514|UniProtKB=H2R3Y8	Carboxylic ester hydrolase	ISS	86008285	PubMed	PTHR11559:SF356	ACETYLCHOLINESTERASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00034	Integrin signalling pathway	P00925	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00558	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	XENTR|Xenbase=XB-GENE-982496|UniProtKB=F6Z8A1	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000016097|UniProtKB=E1B9S9	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	TAS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05730	Endogenous cannabinoid signaling	P05751	Galpha	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00010	B cell activation	P00386	Calcineurin	RAT|RGD=3383|UniProtKB=P20651	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	IDA	12015605	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00231	HSP27	MOUSE|MGI=MGI=88516|UniProtKB=P23927	Alpha-crystallin B chain	ISS			PTHR11527:SF37	ALPHA-CRYSTALLIN B CHAIN
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	HUMAN|HGNC=145|UniProtKB=P63267	Actin, gamma-enteric smooth muscle	IEP	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00057	Wnt signaling pathway	P01444	Wnt	TAKRU|Ensembl=ENSTRUG00000017138|UniProtKB=H2V3X9	Protein Wnt	IDA	8717036	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00036	Interleukin signaling pathway	P00976	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	ANOGA|EnsemblGenome=AGAP007120|UniProtKB=Q7QIX6	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00001	Adrenaline and noradrenaline biosynthesis	P00068	amine translocator	BOVIN|Ensembl=ENSBTAG00000018432|UniProtKB=Q9XS59	Sodium-dependent neutral amino acid transporter B(0)AT2	IC	12719981	PubMed	PTHR11616:SF101	SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER B 0 AT2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00022	General transcription by RNA polymerase I	P00657	TBP	ENTHI|Gene=EHI_020610|UniProtKB=P52653	TATA-box-binding protein 1	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P04393	Ras Pathway	P04570	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IDA	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02769	Purine metabolism	P03118	Guanine Deaminase	MOUSE|MGI=MGI=95678|UniProtKB=Q9R111	Guanine deaminase	ISS	7533042	gi	PTHR11271:SF6	GUANINE DEAMINASE
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P00006	Apoptosis signaling pathway	P00269	MAPK	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00048	PI3 kinase pathway	P01182	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00029	Huntington disease	P00778	NMDA receptor	RAT|RGD=2736|UniProtKB=P35439	Glutamate receptor ionotropic, NMDA 1	IDA	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04384	Gamma-aminobutyric acid synthesis	P04481	Succinic semialdehyde dehydrogenase	DEIRA|EnsemblGenome=DR_A0003|UniProtKB=Q9RZE6	Succinate-semialdehyde dehydrogenase	IC	12891648	PubMed	PTHR43353:SF5	SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MOUSE|MGI=MGI=1915021|UniProtKB=Q9CPW4	Actin-related protein 2/3 complex subunit 5	ISS	12473693	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00034	Integrin signalling pathway	P00922	Collagen	MOUSE|MGI=MGI=88453|UniProtKB=P08121	Collagen alpha-1(III) chain	IDA	10778855	PubMed	PTHR24023:SF604	COLLAGEN ALPHA-1 III  CHAIN
P04384	Gamma-aminobutyric acid synthesis	P04480	GABA aminotransferase	ANOGA|EnsemblGenome=AGAP006966|UniProtKB=Q7QIN5	AGAP006966-PA	ISS	8133261	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	BOVIN|Ensembl=ENSBTAG00000000219|UniProtKB=F1MCL3	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00983	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	9395335	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=26105|UniProtKB=Q7Z736	Pleckstrin homology domain-containing family H member 3	ISS			PTHR22903:SF17	PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY H MEMBER 3
P00047	PDGF signaling pathway	P01173	STAT	MONDO|Ensembl=ENSMODG00000028212|UniProtKB=F7BYN4	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05941	GRK3	XENTR|Ensembl=ENSXETG00000030841|UniProtKB=F7C5A3	Protein-serine/threonine kinase	ISS	10852916	PubMed	PTHR24355:SF18	PROTEIN-SERINE/THREONINE KINASE
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IDA	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P02748	Isoleucine biosynthesis	P02994	Branched chain amino acid aminotransferase	ARATH|TAIR=AT3G19710|UniProtKB=Q9LE06	Methionine aminotransferase BCAT4	ISS			PTHR42825:SF4	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 6-RELATED
P00021	FGF signaling pathway	P00629	PP2A	DROME|FlyBase=FBgn0027492|UniProtKB=Q9VB23	BcDNA.LD34343	ISS	10092233	PubMed	PTHR10257:SF29	BCDNA.LD34343
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02918	dUTP pyrophosphatase	PSEAE|EnsemblGenome=PA5321|UniProtKB=Q9HTN3	Deoxyuridine 5'-triphosphate nucleotidohydrolase	ISS			PTHR11241:SF0	BCDNA.LD08534
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	MONDO|Ensembl=ENSMODG00000003244|UniProtKB=F6THF0	Uncharacterized protein	ISS	9254684	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00005	Angiogenesis	P00226	Delta/Serrate	MACMU|Ensembl=ENSMMUG00000018116|UniProtKB=F7FGM9	Delta-like protein	ISS	1286675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IC	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=1339967|UniProtKB=B1AR69	Protein Myh13	IC	10938134	PubMed	PTHR13140:SF504	MYOSIN-13
P00010	B cell activation	P00384	p38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01173	STAT	MONDO|Ensembl=ENSMODG00000028212|UniProtKB=F7BYN4	Signal transducer and activator of transcription	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	IC	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00585	ECE1-3	ANOGA|EnsemblGenome=AGAP002441|UniProtKB=Q7QC43	AGAP002441-PA	ISS			PTHR11733:SF186	NEPRILYSIN 5, ISOFORM D
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Gene=HTR2A|UniProtKB=P50128	5-hydroxytryptamine receptor 2A	IDA			PTHR24247:SF30	5-HYDROXYTRYPTAMINE RECEPTOR 2A
P02738	De novo purine biosynthesis	P02902	ADP reductase	CANLF|Ensembl=ENSCAFG00000005945|UniProtKB=E2R8P1	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	HUMAN|HGNC=6856|UniProtKB=Q9Y6R4	Mitogen-activated protein kinase kinase kinase 4	IGI	12878610	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=98958|UniProtKB=P22725	Protein Wnt-5a	IDA	11266476	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	BOVIN|Ensembl=ENSBTAG00000016552|UniProtKB=A5PK70	Nucleoside diphosphate kinase	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P00030	Hypoxia response via HIF activation	P00819	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04543	MEKK1/4	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS	12052864	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00036	Interleukin signaling pathway	P00968	Ikk	MACMU|Ensembl=ENSMMUG00000008351|UniProtKB=F7HRV5	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P05730	Endogenous cannabinoid signaling	P05748	mGluR	MOUSE|MGI=MGI=1351338|UniProtKB=P97772	Metabotropic glutamate receptor 1	ISS	8314195	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_56687|UniProtKB=C3YC50	Putative uncharacterized protein	IDA	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00237	FRP	CHICK|Gene=SFRP1|UniProtKB=Q9DEQ4	Secreted frizzled-related protein 1	ISS	9096311	PubMed	PTHR11309:SF87	SECRETED FRIZZLED-RELATED PROTEIN 1
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01168	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00018	EGF receptor signaling pathway	P00562	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00055	Transcription regulation by bZIP transcription factor	P01386	TFIIEbeta	DANRE|ZFIN=ZDB-GENE-030131-6794|UniProtKB=Q6NXA3	Transcription initiation factor IIE subunit beta	ISS	189964	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P00034	Integrin signalling pathway	P00920	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00513	Op18/stathmin	MONDO|Ensembl=ENSMODG00000014027|UniProtKB=F6V9E8	Stathmin	ISS	http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=3925	Website	PTHR10104:SF5	STATHMIN
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	RCA			PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05915	Opioid proenkephalin pathway	P05987	peptide F	XENTR|Xenbase=XB-GENE-942760|UniProtKB=F6Y5F6	Uncharacterized protein	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00006	Apoptosis signaling pathway	P00260	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01332	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	BRAFL|Gene=BRAFLDRAFT_59748|UniProtKB=C3ZEW2	Putative uncharacterized protein	ISS			PTHR23050:SF263	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00238	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	87226391	PubMed	PTHR24070:SF385	GTPASE HRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MOUSE|MGI=MGI=98327|UniProtKB=P30873	Somatostatin receptor type 1	IDA			PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05934	ELK1	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	RCA	11279280	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	ARATH|TAIR=AT1G55520|UniProtKB=P28148	TATA-box-binding protein 2	ISS	11988536	PubMed	PTHR10126:SF36	TATA-BOX-BINDING PROTEIN 1-RELATED
P00005	Angiogenesis	P00246	Ang-2	HUMAN|HGNC=485|UniProtKB=O15123	Angiopoietin-2	IGI	9204896	PubMed	PTHR19143:SF199	ANGIOPOIETIN-2
P00052	TGF-beta signaling pathway	P01286	TGFbeta	RAT|RGD=620105|UniProtKB=F1MAE8	Protein Gdf7	ISS	9759503	PubMed	PTHR11848:SF160	GROWTH/DIFFERENTIATION FACTOR 7
P00029	Huntington disease	P00807	Actin	USTMA|Gene=UMAG_11232|UniProtKB=A0A0D1DMT3	Chromosome 22, whole genome shotgun sequence	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	CANLF|Gene=PSEN1|UniProtKB=Q6RH31	Presenilin-1	TAS	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	PANTR|Ensembl=ENSPTRG00000022245|UniProtKB=H2QZ29	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05918	p38 MAPK pathway	P06039	MSK2	PANTR|Ensembl=ENSPTRG00000003839|UniProtKB=H2Q401	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF41	RIBOSOMAL PROTEIN S6 KINASE ALPHA-4
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12539654	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01153	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CHICK|Ensembl=ENSGALG00000015336|UniProtKB=Q03481	Alpha8 subunit of nicotinic acetylcholine receptor	IC	11404397	PubMed	PTHR18945:SF761	ALPHA8 SUBUNIT OF NICOTINIC ACETYLCHOLINE RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01205	NOS	MONDO|Ensembl=ENSMODG00000003903|UniProtKB=F6S3S1	Nitric oxide synthase	ISS	10435050	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00018	EGF receptor signaling pathway	P00550	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	4504111	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00048	PI3 kinase pathway	P01182	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	91232861	PubMed	PTHR24070:SF385	GTPASE HRAS
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MOUSE|MGI=MGI=101848|UniProtKB=P62881	Guanine nucleotide-binding protein subunit beta-5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00059	p53 pathway	P04633	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00633	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00552	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00005	Angiogenesis	P00256	PLC-gamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00011	Blood coagulation	P00454	FVII	BOVIN|Ensembl=ENSBTAG00000007411|UniProtKB=P22457	Coagulation factor VII	ISS	119765	gi	PTHR44064:SF1	COAGULATION FACTOR VII
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00053	T cell activation	P01307	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	MOUSE|MGI=MGI=88396|UniProtKB=P12657	Muscarinic acetylcholine receptor M1	ISS	12915051	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT3G18040|UniProtKB=Q9LV37	Mitogen-activated protein kinase 9	ISS	12787066	PubMed	PTHR24055:SF246	MITOGEN-ACTIVATED PROTEIN KINASE 15-RELATED
P00056	VEGF signaling pathway	P01425	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P02740	De novo pyrimidine ribonucleotides biosythesis	P02926	Aspartate carbamoyltransferase	HALSA|EnsemblGenome=VNG_6309G|UniProtKB=Q9HHN4	Aspartate carbamoyltransferase	ISS			PTHR11405:SF16	ASPARTATE CARBAMOYLTRANSFERASE, CHLOROPLASTIC
P00030	Hypoxia response via HIF activation	P00820	HIF-1beta	PANTR|Ensembl=ENSPTRG00000001266|UniProtKB=H2R3D7	Aryl hydrocarbon receptor nuclear translocator	ISS	7836384	PubMed	PTHR23042:SF50	ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00058	mRNA splicing	P01475	U2AF65	HUMAN|HGNC=23019|UniProtKB=Q15696	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2	ISS			PTHR12620:SF28	U2 SMALL NUCLEAR RIBONUCLEOPROTEIN AUXILIARY FACTOR 35 KDA SUBUNIT-RELATED PROTEIN 2
P00024	Glycolysis	P00673	Triosephosphate isomerase	DROME|FlyBase=FBgn0086355|UniProtKB=P29613	Triosephosphate isomerase	RCA			PTHR21139:SF15	TRIOSEPHOSPHATE ISOMERASE
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	MACMU|Ensembl=ENSMMUG00000007605|UniProtKB=F6SJQ8	Uncharacterized protein	ISS	96032356	PubMed	PTHR11958:SF22	EXCITATORY AMINO ACID TRANSPORTER 5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	DANRE|ZFIN=ZDB-GENE-040625-167|UniProtKB=Q6IQP4	RAP1A, member of RAS oncogene family	ISS	8576107	PubMed	PTHR24070:SF284	RAP1A, MEMBER OF RAS ONCOGENE FAMILY
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00054	Toll receptor signaling pathway	P01375	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00047	PDGF signaling pathway	P01172	c-Myc	RAT|RGD=3130|UniProtKB=P09416	Myc proto-oncogene protein	ISS	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P02728	Arginine biosynthesis	P02848	N-acetylglutamate synthase	LEPIN|EnsemblGenome=LA_2692|UniProtKB=Q8F2S6	Acetylglutamate kinase	ISS			PTHR23342:SF0	N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02913	Thymidylate synthase	RAT|RGD=3921|UniProtKB=P45352	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	ORNAN|Ensembl=ENSOANG00000000493|UniProtKB=F7EPA8	Uncharacterized protein	ISS	12441358	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P05912	Dopamine receptor mediated signaling pathway	P05964	GNAZ	MOUSE|MGI=MGI=95780|UniProtKB=O70443	Guanine nucleotide-binding protein G(z) subunit alpha	IDA	16814816	PubMed	PTHR10218:SF65	GUANINE NUCLEOTIDE-BINDING PROTEIN G Z  SUBUNIT ALPHA
P00060	Ubiquitin proteasome pathway	P01491	E2	BOVIN|Ensembl=ENSBTAG00000010982|UniProtKB=Q32P99	Ubiquitin-conjugating enzyme E2 B	ISS			PTHR43898:SF6	UBIQUITIN-CONJUGATING ENZYME E2 B
P06959	CCKR signaling map	G06982	MCL1	HUMAN|HGNC=6943|UniProtKB=Q07820	Induced myeloid leukemia cell differentiation protein Mcl-1	RCA	9880563	PubMed	PTHR11256:SF46	INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN MCL-1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P06211	BMP/activin signaling pathway-drosophila	P06256	Full-length  BMP orthologous ligand	DROME|FlyBase=FBgn0024234|UniProtKB=P27091	Protein 60A	RCA	10353905	PubMed	PTHR11848:SF54	PROTEIN 60A-RELATED
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	MOUSE|MGI=MGI=95814|UniProtKB=Q60934	Glutamate receptor ionotropic, kainate 1	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	BOVIN|Ensembl=ENSBTAG00000002295|UniProtKB=F1N177	Uncharacterized protein	ISS	10664585	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	IDA	10851062	PubMed	PTHR24055:SF330	SUBFAMILY NOT NAMED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00036	Interleukin signaling pathway	P00990	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00581	Guanylate cyclase	CAEEL|WormBase=WBGene00001536|UniProtKB=E7EAU8	Receptor-type guanylate cyclase gcy-9	ISS			PTHR11920:SF373	GUANYLATE CYCLASE
P00047	PDGF signaling pathway	P01153	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01154	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	IC	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00629	PP2A	MOUSE|MGI=MGI=2388480|UniProtKB=Q6PD28	Protein Ppp2r5b	ISS	10092233	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CHICK|Gene=CHRM4|UniProtKB=P17200	Muscarinic acetylcholine receptor M4	IDA	91373358	PubMed	PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00034	Integrin signalling pathway	P00951	Jnk	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IDA	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	CHICK|Ensembl=ENSGALG00000003157|UniProtKB=E1C523	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF358	MYOSIN-7B
P00059	p53 pathway	P04623	CBP	CAEEL|WormBase=WBGene00000366|UniProtKB=P34545	Protein cbp-1	ISS	8413673	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00047	PDGF signaling pathway	P01142	p90RSK	XENTR|Xenbase=XB-GENE-479496|UniProtKB=F6S876	Ribosomal protein S6 kinase	ISS	3368449	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00001	Adrenaline and noradrenaline biosynthesis	P00068	amine translocator	CANLF|Ensembl=ENSCAFG00000005946|UniProtKB=E2R9L9	Transporter	ISS	12719981	PubMed	PTHR11616:SF101	SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER B 0 AT2
P00018	EGF receptor signaling pathway	P00558	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	IGI	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00053	T cell activation	P01320	PLC-gamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00029	Huntington disease	P00775	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000005917|UniProtKB=F6QM53	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00021	FGF signaling pathway	P00629	PP2A	BOVIN|Ensembl=ENSBTAG00000001862|UniProtKB=Q5E9Q7	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform	ISS	9125135	PubMed	PTHR11871:SF1	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B BETA ISOFORM
P00048	PI3 kinase pathway	P01199	Galpha	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01465	Ggamma	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00059	p53 pathway	G04694	p110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	MOUSE|MGI=MGI=95815|UniProtKB=P39087	Glutamate receptor ionotropic, kainate 2	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	CANLF|Ensembl=ENSCAFG00000004882|UniProtKB=F1PAE3	Uncharacterized protein	ISS	12086949	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00049	Parkinson disease	P01211	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01182	Ras	CAEEL|WormBase=WBGene00002335|UniProtKB=P22981	Ras protein let-60	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00023	General transcription regulation	P00668	TFIIB	ARATH|TAIR=AT2G45100|UniProtKB=F4IW19	Cyclin/Brf1-like TBP-binding protein	ISS			PTHR11618:SF4	TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT
P00053	T cell activation	P01306	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	ARATH|TAIR=AT4G34460|UniProtKB=P49177	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF48	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA
P00056	VEGF signaling pathway	P01418	Paxillin	RAT|RGD=1305759|UniProtKB=Q66H76	Paxillin	ISS	9182576	PubMed	PTHR24216:SF11	PAXILLIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00739	AGS3	HUMAN|HGNC=29501|UniProtKB=P81274	G-protein-signaling modulator 2	IDA	11121039	PubMed	PTHR10098:SF100	G-PROTEIN-SIGNALING MODULATOR 2
P00053	T cell activation	P01305	Calmodulin	BRAFL|Gene=BRAFLDRAFT_124869|UniProtKB=C3ZEW0	Putative uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF263	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	IC	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00010	B cell activation	P00384	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00053	T cell activation	P01311	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IDA	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	TAS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	HUMAN|HGNC=18381|UniProtKB=Q8IV01	Synaptotagmin-12	RCA			PTHR10024:SF252	SYNAPTOTAGMIN-12
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00012	Cadherin signaling pathway	P00467	alpha-catenin	MONDO|Ensembl=ENSMODG00000012050|UniProtKB=F7ALE8	Uncharacterized protein	ISS	1904011	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00010	B cell activation	P00391	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00029	Huntington disease	P00807	Actin	PANTR|Ensembl=ENSPTRG00000018890|UniProtKB=Q5R1X3	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00048	PI3 kinase pathway	P01177	P110ACT	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04574	PLD	CANLF|Ensembl=ENSCAFG00000015246|UniProtKB=J9P1D8	Uncharacterized protein	ISS	15668389	PubMed	PTHR18896:SF57	PHOSPHOLIPASE D1
P04398	p53 pathway feedback loops 2	P04651	Ras	CAEBR|Gene=CBG06092|UniProtKB=A8X0X5	Protein CBR-LET-60	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	CHICK|Ensembl=ENSGALG00000000227|UniProtKB=Q90635	Dihydropyrimidinase-related protein 2	TAS	7637782	PubMed	PTHR11647:SF56	DIHYDROPYRIMIDINASE-RELATED PROTEIN 2
P00030	Hypoxia response via HIF activation	P00819	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	TAS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00011	Blood coagulation	P00421	alpha1-antitrypsin	PANTR|Ensembl=ENSPTRG00000023666|UniProtKB=H2R1G9	Uncharacterized protein	ISS	225768	gi	PTHR11461:SF165	ALPHA-1-ANTITRYPSIN-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00034	Integrin signalling pathway	P00941	Integrin alpha	RAT|RGD=621634|UniProtKB=B5DEG1	Protein Itga8	ISS	3487386	PubMed	PTHR23220:SF5	INTEGRIN ALPHA-8
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MOUSE|MGI=MGI=109356|UniProtKB=O09044	Synaptosomal-associated protein 23	IC	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00053	T cell activation	P01311	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2049|UniProtKB=P30543	Adenosine receptor A2a	IDA			PTHR24246:SF27	ADENOSINE RECEPTOR A2A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	PANTR|Ensembl=ENSPTRG00000011049|UniProtKB=H2QGF9	Glycogen synthase kinase 3 alpha	ISS	12086949	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00004	Alzheimer disease-presenilin pathway	P00114	actin	STRPU|EnsemblGenome=SPU_006797|UniProtKB=W4XTP5	Uncharacterized protein	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00021	FGF signaling pathway	P00628	JNK1-3	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00059	p53 pathway	G04701	PML	HUMAN|HGNC=9113|UniProtKB=P29590	Protein PML	IDA	12810724	PubMed	PTHR45211:SF1	PROTEIN PML
P00005	Angiogenesis	P00223	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00239	Eph	MACMU|Ensembl=ENSMMUG00000020965|UniProtKB=F7H0J3	EPH-related receptor tyrosine kinase ligand 2	ISS			PTHR11304:SF17	EPHRIN-B1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P02724	Alanine biosynthesis	P02815	Branched chain amino acid aminotransferase	CAEEL|WormBase=WBGene00001149|UniProtKB=P54688	Branched-chain-amino-acid aminotransferase, cytosolic	ISS			PTHR11825:SF44	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	BOVIN|Ensembl=ENSBTAG00000015802|UniProtKB=F1MQ10	Uncharacterized protein	ISS	608972	OMIM	PTHR22952:SF96	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00006	Apoptosis signaling pathway	P00260	AKT	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	ISS	12719720	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00046	Oxidative stress response	P01131	MKP5	PANTR|Ensembl=ENSPTRG00000002653|UniProtKB=P0C594	Dual specificity phosphatase DUPD1	ISS			PTHR10159:SF114	DUAL SPECIFICITY PHOSPHATASE DUPD1
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	RAT|RGD=2062|UniProtKB=P26817	Beta-adrenergic receptor kinase 1	IDA	8288567	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01472	Histone deacetylase	SCHPO|PomBase=SPBC36.05c|UniProtKB=O59702	Histone deacetylase clr6	IDA	10485845	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	BACSU|EnsemblGenome=BSU21820|UniProtKB=P11044	Thymidylate synthase 2	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00057	Wnt signaling pathway	P01428	Frizzled	RAT|RGD=628817|UniProtKB=Q8K4C8	Frizzled homolog 9 (Drosophila)	ISS	11212302	PubMed	PTHR11309:SF79	FRIZZLED-9
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	CHICK|Ensembl=ENSGALG00000002859|UniProtKB=F6UBD2	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00029	Huntington disease	P00788	Calpain	MOUSE|MGI=MGI=1100859|UniProtKB=O08688	Calpain-5	IDA	11675509	PubMed	PTHR10183:SF370	CALPAIN-5
P00029	Huntington disease	P00785	Cytochrome c	TRYB2|Gene=Tb927.8.1890|UniProtKB=D6XKS6	Cytochrome c1, heme protein, mitochondrial	ISS	15163634	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	IC	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00036	Interleukin signaling pathway	P00977	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00054	Toll receptor signaling pathway	P01369	MKK1	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	RCA	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	MACMU|Ensembl=ENSMMUG00000022872|UniProtKB=F6WMJ4	Low-density lipoprotein receptor-related protein 3	ISS	11907044	PubMed	PTHR44062:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	MACMU|Ensembl=ENSMMUG00000007096|UniProtKB=F7ERG6	G protein-activated inward rectifier potassium channel 1	ISS	2433589	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00049	Parkinson disease	P01242	Casein kinase I	DROME|FlyBase=FBgn0032650|UniProtKB=Q9VJC2	CG7094	IDA	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	TAS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00014	Cholesterol biosynthesis	P00493	Geranyl trans-transferase	PANTR|Ensembl=ENSPTRG00000001422|UniProtKB=H2Q079	Farnesyl diphosphate synthase	ISS	O64905	SPACC	PTHR11525:SF0	FARNESYL PYROPHOSPHATE SYNTHASE
P00018	EGF receptor signaling pathway	P00564	Rac	ENTHI|EnsemblGenome=EHI_070730|UniProtKB=C4M5T0	Rho family GTPase	IGI	97082968	PubMed	PTHR24072:SF117	RHO-RELATED PROTEIN RACC
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CAEBR|Gene=CBG17587|UniProtKB=A8XRA5	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00021	FGF signaling pathway	P00623	FGF	PANTR|Ensembl=ENSPTRG00000017361|UniProtKB=H2QRP4	Fibroblast growth factor	ISS	12057924	PubMed	PTHR11486:SF86	FIBROBLAST GROWTH FACTOR 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IDA	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00049	Parkinson disease	P01217	beta-Synuclein	HUMAN|HGNC=11140|UniProtKB=Q16143	Beta-synuclein	IDA	11683992	PubMed	PTHR13820:SF4	BETA-SYNUCLEIN
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	DANRE|ZFIN=ZDB-GENE-990415-247|UniProtKB=P79732	Ribonucleoside-diphosphate reductase large subunit	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	TAS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00049	Parkinson disease	P01233	Elk-1	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	IDA	11279280	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P06959	CCKR signaling map	G06970	IEX1	HUMAN|HGNC=5392|UniProtKB=P46695	Radiation-inducible immediate-early gene IEX-1	RCA	17704804	PubMed	PTHR16915:SF0	RADIATION-INDUCIBLE IMMEDIATE-EARLY GENE IEX-1
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	MACMU|Ensembl=ENSMMUG00000020134|UniProtKB=F6U055	Uncharacterized protein	ISS	9118222	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02778	Sulfate assimilation	P03167	Sulfate adenylyltransferase	TAKRU|Ensembl=ENSTRUG00000010020|UniProtKB=H2TKK7	Uncharacterized protein	ISS			PTHR11055:SF16	BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE 2
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000005792|UniProtKB=F6VTR8	Uncharacterized protein	ISS	12507995	PubMed	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00011	Blood coagulation	P00443	Fibrin polymer cross-linked	MACMU|Ensembl=ENSMMUG00000021302|UniProtKB=F6UZ87	Uncharacterized protein	ISS	6575700	PubMed	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	ANOGA|EnsemblGenome=AGAP007120|UniProtKB=Q7QIX6	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	DICPU|Gene=DICPUDRAFT_93216|UniProtKB=F1A421	Guanine nucleotide-binding protein subunit beta	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04398	p53 pathway feedback loops 2	P04651	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00018	EGF receptor signaling pathway	G01511	SPRY	RAT|RGD=1311472|UniProtKB=Q5HZA2	Protein Spry2	IGI	12815057	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	MACMU|Ensembl=ENSMMUG00000021075|UniProtKB=F7GY91	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P06959	CCKR signaling map	P07088	RYR1/2/3	HUMAN|HGNC=10485|UniProtKB=Q15413	Ryanodine receptor 3	RCA	21786193	PubMed	PTHR13715:SF16	RYANODINE RECEPTOR 3
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00023	General transcription regulation	P00658	TBP-associated factors	MOUSE|MGI=MGI=3039562|UniProtKB=Q6NZA9	Transcription initiation factor TFIID subunit 9B	ISS			PTHR12595:SF3	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 9B
P00054	Toll receptor signaling pathway	P01375	JNK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	ISS	11707292	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	DANRE|ZFIN=ZDB-GENE-040718-93|UniProtKB=Q6DGZ5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01078	VAChT	ANOGA|EnsemblGenome=AGAP003684|UniProtKB=A0NDL1	AGAP003684-PA	IC	21863848	PubMed	PTHR23506:SF4	PORTABELLA
P00019	Endothelin signaling pathway	P00577	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00055	Transcription regulation by bZIP transcription factor	P01395	TFIIE	RAT|RGD=1306851|UniProtKB=G3V992	General transcription factor II E, polypeptide 1 (Alpha subunit)	ISS	189964	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00005	Angiogenesis	P00244	MAPKAPK2/3	PANTR|Ensembl=ENSPTRG00000014968|UniProtKB=H2QMP5	Mitogen-activated protein kinase-activated protein kinase 3	ISS	11335727	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04393	Ras Pathway	P04542	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00392	I kappa B	RAT|RGD=3171|UniProtKB=Q63746	NF-kappa-B inhibitor alpha	ISS	12637573	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00056	VEGF signaling pathway	P01425	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	3755548	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00047	PDGF signaling pathway	P01162	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00005	Angiogenesis	P00226	Delta/Serrate	PANTR|Ensembl=ENSPTRG00000013250|UniProtKB=H2QJZ0	Delta-like protein	ISS	1286675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	SCHPO|PomBase=SPBC21C3.15c|UniProtKB=Q9P7K9	Putative aldehyde dehydrogenase-like protein C21C3	IC			PTHR11699:SF25	ALDEHYDE DEHYDROGENASE-LIKE PROTEIN YHR039C-RELATED
P00021	FGF signaling pathway	P00627	ERK1-2	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00234	Grb2	MACMU|Ensembl=ENSMMUG00000005327|UniProtKB=F7GJG7	GRB2-related adapter protein	ISS			PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	PHYPA|Gene=PHYPADRAFT_170715|UniProtKB=A9TLC7	Rop-family small GTPase	ISS			PTHR24072:SF194	RAC-LIKE GTP-BINDING PROTEIN ARAC4-RELATED
P00012	Cadherin signaling pathway	P00475	Frizzled	PANTR|Ensembl=ENSPTRG00000012855|UniProtKB=H2QJA9	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF126	FRIZZLED-5
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00005	Angiogenesis	P00185	JAK1	CHICK|Ensembl=ENSGALG00000011031|UniProtKB=F1NMJ9	Tyrosine-protein kinase	ISS	11929133	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00029	Huntington disease	P00774	Dynein complex	BOVIN|Ensembl=ENSBTAG00000018560|UniProtKB=F1MRU4	Uncharacterized protein	ISS	9454836	PubMed	PTHR10676:SF242	DYNEIN HEAVY CHAIN 3, AXONEMAL
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00005	Angiogenesis	P00254	GTPase	PANTR|Ensembl=ENSPTRG00000014922|UniProtKB=H2QML4	Uncharacterized protein	ISS	12169092	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00012	Cadherin signaling pathway	P00477	GSK3beta	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05913	Enkephalin release	P05974	G-Protein (i)	ORNAN|Ensembl=ENSOANG00000003489|UniProtKB=F7FSE3	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IDA	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00018	EGF receptor signaling pathway	G01511	SPRY	RAT|RGD=1309293|UniProtKB=B5DFH3	Protein Spry1	ISS	12882970	PubMed	PTHR12365:SF10	PROTEIN SPROUTY HOMOLOG 1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	HUMAN|HGNC=3343|UniProtKB=P19622	Homeobox protein engrailed-2	IEP	12356903	PubMed	PTHR24341:SF5	HOMEOBOX PROTEIN ENGRAILED-2
P00057	Wnt signaling pathway	P01431	LRP5/6	RAT|RGD=1309329|UniProtKB=F1MAD0	Protein Lrp5	ISS	11907044	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00053	T cell activation	P01315	Calcineurin	PANTR|Ensembl=ENSPTRG00000016315|UniProtKB=H2QPY6	Serine/threonine-protein phosphatase	ISS	12015605	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00633	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IGI	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P04393	Ras Pathway	P04542	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04542	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	ISS	12488551	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00186	FGFR-1	PANTR|Ensembl=ENSPTRG00000020176|UniProtKB=H2R210	Fibroblast growth factor receptor	ISS	2544996	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P05915	Opioid proenkephalin pathway	P05985	Mu or Delta receptor	RAT|RGD=3233|UniProtKB=P33533	Delta-type opioid receptor	RCA	11259498	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P02750	Lipoate_biosynthesis	P03003	Lipoyl-protein ligase	PSEAE|EnsemblGenome=PA3997|UniProtKB=Q9X6V9	Octanoyltransferase	ISS			PTHR10993:SF2	OCTANOYLTRANSFERASE
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	MOUSE|MGI=MGI=94941|UniProtKB=P51141	Segment polarity protein dishevelled homolog DVL-1	TAS	7906389	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P00005	Angiogenesis	P00238	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00057	Wnt signaling pathway	P01444	Wnt	BOVIN|Gene=WNT16|UniProtKB=Q5E9U6	Protein Wnt-16	ISS	8717036	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=1855700|UniProtKB=O55134	Protocadherin-12	IDA	8120095	PubMed	PTHR24028:SF42	PROTOCADHERIN-12
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	ORNAN|Ensembl=ENSOANG00000010302|UniProtKB=F6TDQ6	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00029	Huntington disease	P00777	CBP	ARATH|TAIR=AT1G79000|UniProtKB=Q9C5X9	Histone acetyltransferase HAC1	IDA	10769018	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00034	Integrin signalling pathway	P00938	Cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00057	Wnt signaling pathway	P01437	TCF	BOVIN|Ensembl=ENSBTAG00000006844|UniProtKB=E1BJ93	Uncharacterized protein	ISS	11266476	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P04393	Ras Pathway	P04570	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01472	Histone deacetylase	CAEBR|Gene=CBG04588|UniProtKB=A8WY01	Histone deacetylase	ISS	10485845	PubMed	PTHR10625:SF171	HISTONE DEACETYLASE 2
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00012	Cadherin signaling pathway	P00470	F-actin	ORNAN|Ensembl=ENSOANG00000007716|UniProtKB=F6UDX9	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	CANLF|Ensembl=ENSCAFG00000004930|UniProtKB=E2RFB5	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	PANTR|Ensembl=ENSPTRG00000022245|UniProtKB=H2QZ29	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	ARATH|TAIR=AT2G32400|UniProtKB=Q9SDQ4	Glutamate receptor 3.7	IC			PTHR43891:SF15	GLUTAMATE RECEPTOR 3.7
P00057	Wnt signaling pathway	P01435	SWI/SNF	PANTR|Ensembl=ENSPTRG00000002778|UniProtKB=H2Q2A9	Uncharacterized protein	ISS	11532957	PubMed	PTHR10799:SF812	LYMPHOID-SPECIFIC HELICASE
P04393	Ras Pathway	P04567	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	IDA	14505573	PubMed	PTHR10048:SF14	PI-3 KINASE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	P01465	Ggamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00005	Angiogenesis	P00205	GAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00056	VEGF signaling pathway	P01423	p38MAPK	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	ISS	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00047	PDGF signaling pathway	P01145	c-fos	TAKRU|Ensembl=ENSTRUG00000010431|UniProtKB=H2TNK9	Uncharacterized protein	ISS			PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00005	Angiogenesis	P00182	p38MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05918	p38 MAPK pathway	P06026	MEKK4	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS	97236778	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	CAEEL|WormBase=WBGene00018764|UniProtKB=O01579	Uncharacterized protein	ISS			PTHR11482:SF56	SUBFAMILY NOT NAMED
P00053	T cell activation	P01335	jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00047	PDGF signaling pathway	P01149	MNK1/2	BOVIN|Ensembl=ENSBTAG00000018049|UniProtKB=E1BCH7	Uncharacterized protein	ISS	11463832	PubMed	PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00030	Hypoxia response via HIF activation	P00814	P300	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	TAS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	STRCO|EnsemblGenome=CAA20396|UniProtKB=O86781	Glutamine--fructose-6-phosphate aminotransferase [isomerizing]	ISS			PTHR10937:SF0	GH12731P-RELATED
P02747	Histidine biosynthesis	P02993	Phosphoribosylformimino-5-amino-1-phosphoribosyl-4 imadazol carboxamide isomerase	GLOVI|EnsemblGenome=BAC88647|UniProtKB=Q7NMQ9	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase	ISS			PTHR43090:SF2	1- 5-PHOSPHORIBOSYL -5-  5-PHOSPHORIBOSYLAMINO METHYLIDENEAMINO  IMIDAZOLE-4-CARBOXAMIDE ISOMERASE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00059	p53 pathway	G01579	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DANRE|ZFIN=ZDB-GENE-000330-4|UniProtKB=Q1MTI1	Uncharacterized protein	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	ISS	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05731	GABA-B receptor II signaling	P05760	AC	PANTR|Ensembl=ENSPTRG00000020589|UniProtKB=H2QWQ6	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00021	FGF signaling pathway	P00644	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	IPI	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04397	p53 pathway by glucose deprivation	P04640	p53	CANLF|Gene=TP53|UniProtKB=Q29537	Cellular tumor antigen p53	TAS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	RAT|RGD=2742|UniProtKB=P23385	Metabotropic glutamate receptor 1	ISS	9407094	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00006	Apoptosis signaling pathway	P00276	TRAIL-R	HUMAN|HGNC=11906|UniProtKB=O14798	Tumor necrosis factor receptor superfamily member 10C	RCA			PTHR23097:SF143	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10C-RELATED
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	PANTR|Ensembl=ENSPTRG00000000543|UniProtKB=H2PYN8	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00047	PDGF signaling pathway	P01142	p90RSK	HUMAN|HGNC=10435|UniProtKB=Q9UK32	Ribosomal protein S6 kinase alpha-6	ISS	6755374	gi	PTHR24351:SF98	RIBOSOMAL PROTEIN S6 KINASE ALPHA-6
P00018	EGF receptor signaling pathway	P00546	GAP	CANLF|Ensembl=ENSCAFG00000007674|UniProtKB=E2QUM7	Uncharacterized protein	ISS	20475167	gi	PTHR10194:SF21	RAS GTPASE-ACTIVATING PROTEIN 2
P00019	Endothelin signaling pathway	P00586	Gq	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00025	Hedgehog signaling pathway	P00687	Cubitus interruptus repressor	DANRE|ZFIN=ZDB-GENE-041111-162|UniProtKB=F1QSH8	Uncharacterized protein	ISS	10976059	PubMed	PTHR19818:SF5	TRANSCRIPTIONAL ACTIVATOR GLI3
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	ARATH|TAIR=AT1G29900|UniProtKB=Q42601	Carbamoyl-phosphate synthase large chain, chloroplastic	ISS			PTHR11405:SF47	CARBAMOYL-PHOSPHATE SYNTHASE LARGE CHAIN, CHLOROPLASTIC
P00047	PDGF signaling pathway	P01143	ERK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00047	PDGF signaling pathway	P01159	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000004742|UniProtKB=H2Q5K1	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P00049	Parkinson disease	P01236	Casein kinase II	MONDO|Ensembl=ENSMODG00000019523|UniProtKB=F6VCI6	Uncharacterized protein	ISS	10806215	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00006	Apoptosis signaling pathway	P00274	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	CANLF|Ensembl=ENSCAFG00000005204|UniProtKB=B6V8E6	Catenin beta-1	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IDA	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02740	De novo pyrimidine ribonucleotides biosythesis	P02924	Uridylate kinase	YEAST|SGD=S000001507|UniProtKB=P15700	Uridylate kinase	ISS			PTHR23359:SF107	UMP-CMP KINASE
P00029	Huntington disease	P00807	Actin	DANRE|ZFIN=ZDB-GENE-030131-1229|UniProtKB=Q6DHS1	Actin, alpha 2, smooth muscle, aorta	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02775	Salvage pyrimidine ribonucleotides	P03150	Uridine kinase	CHICK|Ensembl=ENSGALG00000003510|UniProtKB=F1NMM9	Uridine-cytidine kinase	ISS			PTHR10285:SF70	URIDINE-CYTIDINE KINASE 2
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01465	Ggamma	PANTR|Ensembl=ENSPTRG00000006342|UniProtKB=H2Q8A8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04661	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	TAS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00015	Circadian clock system	G01503	per	CANLF|Ensembl=ENSCAFG00000016984|UniProtKB=E2R0I6	Uncharacterized protein	ISS	12782655	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	TAS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	PANTR|Ensembl=ENSPTRG00000022214|UniProtKB=H2QZ14	Uncharacterized protein	ISS	8910586	PubMed	PTHR23036:SF89	INTERLEUKIN-13 RECEPTOR SUBUNIT ALPHA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MONDO|Ensembl=ENSMODG00000007194|UniProtKB=F6X9N6	Actin-related protein 2/3 complex subunit 5	ISS	12473693	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00018	EGF receptor signaling pathway	P00551	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	IGI	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	TAS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	ORNAN|Ensembl=ENSOANG00000013961|UniProtKB=F6VPY1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00796	Kainate receptor	MACMU|Ensembl=ENSMMUG00000017431|UniProtKB=F7HPP3	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	HUMAN|HGNC=3025|UniProtKB=P21917	D(4) dopamine receptor	IDA	12181435	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	IGI	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00016	Cytoskeletal regulation by Rho GTPase	P00507	Rho	DROME|FlyBase=FBgn0014020|UniProtKB=P48148	Ras-like GTP-binding protein Rho1	ISS	11973360	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	YEAST|SGD=S000004143|UniProtKB=P52910	Acetyl-coenzyme A synthetase 2	ISS			PTHR24095:SF245	ACETYL-COENZYME A SYNTHETASE 2
P00036	Interleukin signaling pathway	P00983	Raf	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P05918	p38 MAPK pathway	P06031	p38alpha	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00048	PI3 kinase pathway	P01198	FOXO	HUMAN|HGNC=3821|UniProtKB=O43524	Forkhead box protein O3	TAS	12884295	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	RCA	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00029	Huntington disease	P00766	Htt	MACMU|Ensembl=ENSMMUG00000008392|UniProtKB=F6VQZ3	Uncharacterized protein	ISS	7620118	PubMed	PTHR10170:SF10	HUNTINGTIN
P04393	Ras Pathway	P04558	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	ARATH|TAIR=AT5G57015|UniProtKB=Q8VYK9	Casein kinase 1-like protein 12	ISS	10617630	PubMed	PTHR11909:SF298	CASEIN KINASE 1-LIKE PROTEIN 12-RELATED
P00059	p53 pathway	G04691	IGF-BP3	MOUSE|MGI=MGI=96438|UniProtKB=P47878	Insulin-like growth factor-binding protein 3	ISS			PTHR11551:SF3	INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	MONDO|Ensembl=ENSMODG00000024005|UniProtKB=F7A4B3	Uncharacterized protein	ISS			PTHR24072:SF158	RHO-RELATED GTP-BINDING PROTEIN RHOG
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00053	T cell activation	P01322	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	IGI	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=1858236|UniProtKB=Q91ZI0	Cadherin EGF LAG seven-pass G-type receptor 3	IDA	8120095	PubMed	PTHR24026:SF38	CADHERIN EGF LAG SEVEN-PASS G-TYPE RECEPTOR 3
P02751	Lysine biosynthesis	P03007	Diaminopimelate decarboxylase	METJA|EnsemblGenome=MJ_1097|UniProtKB=Q58497	Diaminopimelate decarboxylase	ISS			PTHR43727:SF2	DIAMINOPIMELATE DECARBOXYLASE 1, CHLOROPLASTIC-RELATED
P05915	Opioid proenkephalin pathway	P05994	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000012539|UniProtKB=H2RC03	Uncharacterized protein	ISS			PTHR11824:SF7	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PHANO|EnsemblGenome=SNOG_01139|UniProtKB=H2KNE6	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05915	Opioid proenkephalin pathway	P05994	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00018	EGF receptor signaling pathway	P00564	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	15470041	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00012	Cadherin signaling pathway	P00477	GSK3beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00036	Interleukin signaling pathway	P00965	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00048	PI3 kinase pathway	P01179	PKB	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	TAS	12655147	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01131	MKP5	RAT|RGD=68375|UniProtKB=Q9JIM4	Dual specificity protein phosphatase 12	ISS			PTHR10159:SF293	DUAL SPECIFICITY PROTEIN PHOSPHATASE 12
P00057	Wnt signaling pathway	P01433	SIAH-1	CHICK|Ensembl=ENSGALG00000010395|UniProtKB=E1C3Q9	E3 ubiquitin-protein ligase	ISS			PTHR10315:SF11	E3 UBIQUITIN-PROTEIN LIGASE SIAH2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	HUMAN|HGNC=129|UniProtKB=P68133	Actin, alpha skeletal muscle	ISS	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P05915	Opioid proenkephalin pathway	P05995	proenkephalin	DANRE|ZFIN=ZDB-GENE-030729-31|UniProtKB=A8E7S2	Uncharacterized protein	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	PANTR|Ensembl=ENSPTRG00000000323|UniProtKB=H2PYA3	Uncharacterized protein	ISS	11701344	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000024992|UniProtKB=F6TUR3	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MOUSE|MGI=MGI=102522|UniProtKB=Q8R3Z5	Voltage-dependent L-type calcium channel subunit beta-1	ISS	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04393	Ras Pathway	P04547	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IDA	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00048	PI3 kinase pathway	P01177	P110ACT	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00647	SHP2	DANRE|ZFIN=ZDB-GENE-030131-5911|UniProtKB=F1QZU5	Tyrosine-protein phosphatase non-receptor type	ISS	14534538	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P06664	Gonadotropin-releasing hormone receptor pathway	P06746	Syt IV	MOUSE|MGI=MGI=101759|UniProtKB=P40749	Synaptotagmin-4	RCA			PTHR10024:SF114	SYNAPTOTAGMIN-4
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CAEEL|WormBase=WBGene00004056|UniProtKB=Q8MXI4	Mitogen-activated protein kinase pmk-2	IDA	11707292	PubMed	PTHR24055:SF154	MITOGEN-ACTIVATED PROTEIN KINASE PMK-2
P00053	T cell activation	P01306	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00054	Toll receptor signaling pathway	G01550	Gene trancription	MACMU|Ensembl=ENSMMUG00000016857|UniProtKB=F7BWZ9	Uncharacterized protein	ISS	9528947	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P00005	Angiogenesis	P00223	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P01486	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00011	Blood coagulation	P00429	PN2	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	ISS	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00059	p53 pathway	P01486	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	G01566	TSP1	MONDO|Ensembl=ENSMODG00000000679|UniProtKB=F6WMA0	Uncharacterized protein	ISS	7521539	PubMed	PTHR10199:SF78	THROMBOSPONDIN-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MACMU|Gene=CHRM1|UniProtKB=P56489	Muscarinic acetylcholine receptor M1	IDA	12181435	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00036	Interleukin signaling pathway	P00964	p90RSK	PANTR|Ensembl=ENSPTRG00000000387|UniProtKB=H2PYE3	Ribosomal protein S6 kinase	ISS	15226426	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	MOUSE|MGI=MGI=1277954|UniProtKB=O88786	Interleukin-13 receptor subunit alpha-2	IPI	9725226	PubMed	PTHR23036:SF101	INTERLEUKIN-13 RECEPTOR SUBUNIT ALPHA-2
P00029	Huntington disease	P00782	alpha-Adaptin	BOVIN|Ensembl=ENSBTAG00000019180|UniProtKB=E1BMW2	Uncharacterized protein	ISS	11532990	PubMed	PTHR22780:SF19	AP-2 COMPLEX SUBUNIT ALPHA-1
P00046	Oxidative stress response	P01131	MKP5	MACMU|Ensembl=ENSMMUG00000008844|UniProtKB=F7ES52	Dual specificity protein phosphatase	ISS			PTHR10159:SF309	DUAL SPECIFICITY PROTEIN PHOSPHATASE 1
P02723	Adenine and hypoxanthine salvage pathway	P02810	Adenine phosphoribosyl transferase	MACMU|Ensembl=ENSMMUG00000013824|UniProtKB=F6T5C3	Uncharacterized protein	ISS			PTHR32315:SF3	ADENINE PHOSPHORIBOSYLTRANSFERASE
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00025	Hedgehog signaling pathway	P00691	CBP	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00029	Huntington disease	P00786	ARF	EMENI|EnsemblGenome=CADANIAG00001503|UniProtKB=Q5BEA4	ADP-ribosylation factor (Broad)	ISS	12932731	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	DROME|FlyBase=FBgn0002842|UniProtKB=Q9VP40	Spermatocyte arrest	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00006	Apoptosis signaling pathway	P00311	GCKR	MOUSE|MGI=MGI=1925503|UniProtKB=Q8BPM2	Mitogen-activated protein kinase kinase kinase kinase 5	ISS			PTHR24361:SF324	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 5
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IDA	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00005	Angiogenesis	P00252	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	15210125	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00034	Integrin signalling pathway	P00920	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00006	Apoptosis signaling pathway	P00276	TRAIL-R	HUMAN|HGNC=11907|UniProtKB=Q9UBN6	Tumor necrosis factor receptor superfamily member 10D	RCA			PTHR23097:SF143	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10C-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00029	Huntington disease	P00768	Apaf-1	PANTR|Ensembl=ENSPTRG00000005335|UniProtKB=H2R1S6	Apoptotic protease-activating factor 1	ISS	14526190	PubMed	PTHR22845:SF5	APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
P00034	Integrin signalling pathway	P00923	Arf1	PANTR|Ensembl=ENSPTRG00000005350|UniProtKB=H2Q6P9	ADP-ribosylation factor-like 1	ISS	12932731	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P00019	Endothelin signaling pathway	P00572	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00805	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	HUMAN|HGNC=2091|UniProtKB=P09497	Clathrin light chain B	ISS	11889126	PubMed	PTHR10639:SF2	CLATHRIN LIGHT CHAIN B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IDA	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00010	B cell activation	P00391	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02775	Salvage pyrimidine ribonucleotides	P03153	Cytidylate kinase	CAEEL|WormBase=WBGene00007812|UniProtKB=O17622	UMP-CMP kinase 1	ISS			PTHR23359:SF107	UMP-CMP KINASE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00048	PI3 kinase pathway	P01192	p110	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00054	Toll receptor signaling pathway	P01358	ERK1	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00810	GAPDH	CHLAA|EnsemblGenome=Caur_3729|UniProtKB=A9WBV5	Glyceraldehyde-3-phosphate dehydrogenase	ISS			PTHR43148:SF2	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE C-RELATED
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00260	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00170	Aph-1	HUMAN|HGNC=24080|UniProtKB=Q8WW43	Gamma-secretase subunit APH-1B	IDA	12763021	PubMed	PTHR12889:SF1	GAMMA-SECRETASE SUBUNIT APH-1B
P00011	Blood coagulation	P00458	GP IIIa	CANLF|Ensembl=ENSCAFG00000013735|UniProtKB=F1PPG5	Integrin beta	ISS	386150	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00048	PI3 kinase pathway	P01182	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00035	Interferon-gamma signaling pathway	P00956	SOCS	RAT|RGD=621087|UniProtKB=O88583	Suppressor of cytokine signaling 3	ISS	15032587	PubMed	PTHR44534:SF3	SUPPRESSOR OF CYTOKINE SIGNALING 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ARATH|TAIR=AT3G46520|UniProtKB=P53497	Actin-12	IC	11889126	PubMed	PTHR11937:SF276	ACTIN-12
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02728	Arginine biosynthesis	P02846	Ornithine carbamoyl transferase	STRCO|EnsemblGenome=CAC44590|UniProtKB=Q93JF1	Ornithine carbamoyltransferase	ISS			PTHR11405:SF44	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01181	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IPI	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00036	Interleukin signaling pathway	P00970	Interleukin	PANTR|Ensembl=ENSPTRG00000016154|UniProtKB=H2QPN2	C-X-C motif chemokine	ISS	2007144	PubMed	PTHR10179:SF70	INTERLEUKIN-8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IDA	188830	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DROME|FlyBase=FBgn0001105|UniProtKB=P26308	Guanine nucleotide-binding protein subunit beta-1	IC	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00006	Apoptosis signaling pathway	P00310	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00543	ERK1-2	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00644	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00029	Huntington disease	P00780	Microtubule	BRAFL|Gene=BRAFLDRAFT_124235|UniProtKB=C3Y3Q1	Putative uncharacterized protein	ISS			PTHR11588:SF89	TUBULIN BETA-4 CHAIN
P00021	FGF signaling pathway	P00644	p38	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	IGI	8920915	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00715	AGS3	HUMAN|HGNC=29501|UniProtKB=P81274	G-protein-signaling modulator 2	IDA	11121039	PubMed	PTHR10098:SF100	G-PROTEIN-SIGNALING MODULATOR 2
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CHICK|Ensembl=ENSGALG00000027629|UniProtKB=Q5ZJ03	Guanine nucleotide-binding protein subunit gamma	IC	9754712	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00018	EGF receptor signaling pathway	P00556	PLCgamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IGI	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	ARATH|TAIR=AT2G24360|UniProtKB=Q9ZQ31	Putative serine/threonine/tyrosine kinase	ISS			PTHR23257:SF618	SERINE/THREONINE/TYROSINE KINASE-RELATED
P04393	Ras Pathway	P04558	p38	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	4506785	gi	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00056	VEGF signaling pathway	P01407	Erk	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	P04630	PP2A	XENTR|Xenbase=XB-GENE-957248|UniProtKB=Q6GLE6	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00239	Eph	HUMAN|HGNC=3227|UniProtKB=P52799	Ephrin-B2	IGI	9990854	PubMed	PTHR11304:SF18	EPHRIN-B2
P00012	Cadherin signaling pathway	P00470	F-actin	CHICK|Gene=ACTA2|UniProtKB=P08023	Actin, aortic smooth muscle	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8971|UniProtKB=O00443	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P04395	Vasopressin synthesis	P04597	Signal Peptide	DANRE|ZFIN=ZDB-GENE-030407-2|UniProtKB=F8W5D0	Uncharacterized protein (Fragment)	ISS	1706187	PubMed	PTHR11681:SF13	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00775	Rac	CAEEL|WormBase=WBGene00004287|UniProtKB=Q94124	Ras-related protein rac-2	TAS			PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00046	Oxidative stress response	P01129	JNK1/2	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00583	cPLA2	DANRE|ZFIN=ZDB-GENE-990415-45|UniProtKB=P50392	Cytosolic phospholipase A2	IGI	94299545	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P02738	De novo purine biosynthesis	P02905	Amidophosphoribosyl transferase	ARATH|TAIR=AT2G16570|UniProtKB=Q9SI61	Amidophosphoribosyltransferase 1, chloroplastic	ISS			PTHR11907:SF0	AMIDOPHOSPHORIBOSYLTRANSFERASE
P00006	Apoptosis signaling pathway	P00318	PKCs	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00010	B cell activation	P00371	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CHICK|Ensembl=ENSGALG00000009405|UniProtKB=F1NKF1	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00029	Huntington disease	P00775	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01126	ATF2	BOVIN|Ensembl=ENSBTAG00000002295|UniProtKB=F1N177	Uncharacterized protein	ISS	11390664	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00056	VEGF signaling pathway	P01408	Akt/PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00282	IGFR2	MACMU|Ensembl=ENSMMUG00000015658|UniProtKB=F7AJI7	Uncharacterized protein	ISS	6382022	PubMed	PTHR15071:SF17	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00011	Blood coagulation	P00418	Fibrin monomer	PANTR|Ensembl=ENSPTRG00000016536|UniProtKB=H2RDH7	Uncharacterized protein	ISS	223170	gi	PTHR19143:SF338	FIBRINOGEN GAMMA CHAIN
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	IPI	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PHYPA|Gene=PHYPADRAFT_110341|UniProtKB=Q6TYR6	Beta-tubulin 2	ISS	12932731	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	TAS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00057	Wnt signaling pathway	P01447	Dishevelled	PANTR|Ensembl=ENSPTRG00000008665|UniProtKB=H2QC24	Dishevelled, dsh homolog 2	ISS	10409711	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P04393	Ras Pathway	P04553	PAK	XENTR|Xenbase=XB-GENE-966302|UniProtKB=F6T2E7	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CAEEL|WormBase=WBGene00001187|UniProtKB=Q8MQA1	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IDA	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00059	p53 pathway	G01575	GADD45	MONDO|Ensembl=ENSMODG00000000788|UniProtKB=F6SSE6	Uncharacterized protein	ISS	9827804	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P02738	De novo purine biosynthesis	P02903	Phosphoribosylglycinamide  formyltransferase	YEAST|SGD=S000002816|UniProtKB=P04161	Phosphoribosylglycinamide formyltransferase	ISS			PTHR43369:SF2	PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	PANTR|Ensembl=ENSPTRG00000013893|UniProtKB=H2PZY5	Uncharacterized protein	ISS	10505793	PubMed	PTHR10223:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4
P00018	EGF receptor signaling pathway	P00565	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	IGI	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00010	B cell activation	P00373	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IGI	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	RCA	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00005	Angiogenesis	P00238	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01443	Phospholipase C	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00054	Toll receptor signaling pathway	P01346	TLR	MACMU|Ensembl=ENSMMUG00000012263|UniProtKB=F6UZJ0	Uncharacterized protein	ISS			PTHR24373:SF37	TOLL-LIKE RECEPTOR 9
P00060	Ubiquitin proteasome pathway	P01491	E2	MOUSE|MGI=MGI=109240|UniProtKB=P68037	Ubiquitin-conjugating enzyme E2 L3	ISS	10888878	PubMed	PTHR24068:SF67	UBIQUITIN-CONJUGATING ENZYME E2 L3
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	BOVIN|Ensembl=ENSBTAG00000026519|UniProtKB=Q5E9J7	tRNA-specific adenosine deaminase 2	ISS			PTHR11079:SF92	TRNA-SPECIFIC ADENOSINE DEAMINASE 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04452	proopiomelanocortin	RAT|RGD=3366|UniProtKB=P01194	Pro-opiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1354946|UniProtKB=Q61532	Mitogen-activated protein kinase 6	IDA	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00054	Toll receptor signaling pathway	P01351	TLR2,4,7	MOUSE|MGI=MGI=2176882|UniProtKB=P58681	Toll-like receptor 7	ISS			PTHR44312:SF1	TOLL-LIKE RECEPTOR 7
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00010	B cell activation	P00381	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	HUMAN|HGNC=1389|UniProtKB=Q00975	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	15079861	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95809|UniProtKB=P23819	Glutamate receptor 2	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	CHICK|Ensembl=ENSGALG00000008414|UniProtKB=F1P5N3	Uncharacterized protein	ISS	10409711	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P00036	Interleukin signaling pathway	P00973	PKB	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00941	Integrin alpha	HUMAN|HGNC=6134|UniProtKB=P56199	Integrin alpha-1	IPI	3487386	PubMed	PTHR23220:SF22	INTEGRIN ALPHA-1
P00006	Apoptosis signaling pathway	P00260	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00398	IP3R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	IDA	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	IC	10074940	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00006	Apoptosis signaling pathway	P00274	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEEL|WormBase=WBGene00018620|UniProtKB=O44588	Uncharacterized protein	ISS	3045562	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000039151|UniProtKB=F6R5F6	Uncharacterized protein	ISS	1608964	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	CANLF|Ensembl=ENSCAFG00000005415|UniProtKB=F1PQM2	Uncharacterized protein	ISS	11742073	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2521|UniProtKB=P19020	D(3) dopamine receptor	IDA	11861492	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00053	T cell activation	P01312	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00001	Adrenaline and noradrenaline biosynthesis	P00066	DOPA decarb.	MOUSE|MGI=MGI=94876|UniProtKB=O88533	Aromatic-L-amino-acid decarboxylase	ISS	107930	OMIM	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P05918	p38 MAPK pathway	P06015	p38gamma	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	4506785	gi	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04393	Ras Pathway	P04558	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Gene=DRD2|UniProtKB=Q9GJU1	D(2) dopamine receptor	IDA	11248120	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P04393	Ras Pathway	P04553	PAK	CHICK|Ensembl=ENSGALG00000008058|UniProtKB=F1N8W8	Uncharacterized protein	ISS	7559398	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	HUMAN|HGNC=6698|UniProtKB=O75581	Low-density lipoprotein receptor-related protein 6	IDA	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00012	Cadherin signaling pathway	P00471	Cadherin	MONDO|Ensembl=ENSMODG00000000011|UniProtKB=F6SJ04	Uncharacterized protein	ISS	8120095	PubMed	PTHR43912:SF5	PROTOCADHERIN-9
P00034	Integrin signalling pathway	P00925	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00007	Axon guidance mediated by semaphorins	P00339	CRMP	MOUSE|MGI=MGI=107793|UniProtKB=P97427	Dihydropyrimidinase-related protein 1	ISS	96424532	PubMed	PTHR11647:SF54	DIHYDROPYRIMIDINASE-RELATED PROTEIN 1
P00005	Angiogenesis	P00219	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00024	Glycolysis	P00677	Hexokinase	PANTR|Ensembl=ENSPTRG00000002570|UniProtKB=H2Q205	Uncharacterized protein	RCA			PTHR19443:SF28	HEXOKINASE HKDC1-RELATED
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT3G18040|UniProtKB=Q9LV37	Mitogen-activated protein kinase 9	ISS	10514528	PubMed	PTHR24055:SF246	MITOGEN-ACTIVATED PROTEIN KINASE 15-RELATED
P00054	Toll receptor signaling pathway	P01375	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	HUMAN|HGNC=9559|UniProtKB=Q13200	26S proteasome non-ATPase regulatory subunit 2	ISS			PTHR10943:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	BOVIN|Ensembl=ENSBTAG00000014447|UniProtKB=A4IFF4	Ribosomal protein S6 kinase	ISS	15226426	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P04393	Ras Pathway	P04567	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01219	SAPK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00048	PI3 kinase pathway	P01194	S6K	MONDO|Ensembl=ENSMODG00000014313|UniProtKB=F7BTW0	Ribosomal protein S6 kinase	ISS	15116068	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P05915	Opioid proenkephalin pathway	P05994	G-protein	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00053	T cell activation	P01305	Calmodulin	BOVIN|Ensembl=ENSBTAG00000014583|UniProtKB=P62157	Calmodulin	ISS	10487978	PubMed	PTHR23050:SF335	CALMODULIN, STRIATED MUSCLE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04393	Ras Pathway	P04570	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00796	Kainate receptor	HUMAN|HGNC=4580|UniProtKB=Q13002	Glutamate receptor ionotropic, kainate 2	IDA	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00029	Huntington disease	P00805	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00318	PKCs	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00056	VEGF signaling pathway	P01425	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00059	p53 pathway	P04633	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	TAS	9603989	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	LEIMA|EnsemblGenome=LmjF.35.3960|UniProtKB=E9AFM1	Protein kinase A catalytic subunit isoform 2	ISS	10218114	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	MACMU|Ensembl=ENSMMUG00000009885|UniProtKB=F6YL51	Uncharacterized protein	ISS	11907044	PubMed	PTHR44025:SF7	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B
P00005	Angiogenesis	P00182	p38MAPK	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00006	Apoptosis signaling pathway	P00260	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IDA	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	CHICK|Ensembl=ENSGALG00000009927|UniProtKB=Q5ZHX1	Ras-related protein Rap-1b	ISS	8576107	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_206575|UniProtKB=E9FUX0	Guanine nucleotide binding protein, beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00019	Endothelin signaling pathway	P00566	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	RAT|RGD=1305236|UniProtKB=B0BN93	26S proteasome non-ATPase regulatory subunit 13	ISS	99239941	PubMed	PTHR10539:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13
P00036	Interleukin signaling pathway	P00975	RasGAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	8262392	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00049	Parkinson disease	P01227	20S proteasome	TRYB2|Gene=Tb10.70.0850|UniProtKB=Q38B02	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF12	PROTEASOME SUBUNIT ALPHA TYPE-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	RCA	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00056	VEGF signaling pathway	P01407	Erk	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	STRCO|EnsemblGenome=CAD55214|UniProtKB=P43414	Adenylate kinase	ISS			PTHR23359:SF22	GTP:AMP PHOSPHOTRANSFERASE, MITOCHONDRIAL
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00005	Angiogenesis	P00219	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00566	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04398	p53 pathway feedback loops 2	P04657	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04397	p53 pathway by glucose deprivation	P04641	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00590	IP3 R	CAEEL|WormBase=WBGene00002173|UniProtKB=Q9Y0A1	Inositol 1,4,5-trisphosphate receptor itr-1	ISS	4262086	gi	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00009	Axon guidance mediated by netrin	P00363	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	NAS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00029	Huntington disease	P00807	Actin	CAEBR|Gene=CBG02161|UniProtKB=A8WS32	Protein CBG02161	ISS	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ORYSJ|EnsemblGenome=OS05G0438800|UniProtKB=Q75HX0	Actin	IC	10974003	PubMed	PTHR11937:SF248	SUBFAMILY NOT NAMED
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05913	Enkephalin release	P05974	G-Protein (i)	IXOSC|EnsemblGenome=ISCW009711|UniProtKB=B7Q3T6	THO complex subunit, putative	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	IGI	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=18231|UniProtKB=Q9BYE9	Cadherin-related family member 2	IDA	8120095	PubMed	PTHR44787:SF1	CADHERIN-RELATED FAMILY MEMBER 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00059	p53 pathway	P01486	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	TAS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	CANLF|Ensembl=ENSCAFG00000009967|UniProtKB=F1PGZ2	Muscarinic acetylcholine receptor	ISS	10069496	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00006	Apoptosis signaling pathway	P00318	PKCs	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04392	P53 pathway feedback loops 1	G04683	Cop-1	XENTR|Xenbase=XB-GENE-1014311|UniProtKB=F7CIC4	Uncharacterized protein (Fragment)	ISS	15103385	PubMed	PTHR44080:SF1	E3 UBIQUITIN-PROTEIN LIGASE RFWD2
P04393	Ras Pathway	P04543	MEKK1/4	RAT|RGD=620966|UniProtKB=Q62925	Mitogen-activated protein kinase kinase kinase 1	IDA	8643568	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	IC	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05994	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	9395335	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00589	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MOUSE|MGI=MGI=1339967|UniProtKB=B1AR69	Protein Myh13	ISS	10938134	PubMed	PTHR13140:SF504	MYOSIN-13
P00017	DNA replication	P00531	Pol alpha	PLAF7|EnsemblGenome=PFD0590c|UniProtKB=Q9U0H1	DNA polymerase	ISS	22255708	PubMed	PTHR10322:SF21	DNA POLYMERASE ALPHA CATALYTIC SUBUNIT
P00057	Wnt signaling pathway	P01465	Ggamma	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	ISS	8457205	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00018	EGF receptor signaling pathway	P00562	p38	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	IGI	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00034	Integrin signalling pathway	P00922	Collagen	PANTR|Ensembl=ENSPTRG00000013721|UniProtKB=H2QKR5	Uncharacterized protein	ISS	10778855	PubMed	PTHR44865:SF1	COLLAGEN ALPHA-3 IX  CHAIN
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04547	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	RAT|RGD=3425|UniProtKB=P97887	Presenilin-1	TAS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	HUMAN|HGNC=12441|UniProtKB=P04818	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P02772	Pyruvate metabolism	P03137	Citrate Lyase	DEIRA|EnsemblGenome=DR_2206|UniProtKB=Q9RSB9	Citrate lyase, beta subunit	ISS			PTHR32308:SF0	CITRATE LYASE SUBUNIT BETA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CANLF|Ensembl=ENSCAFG00000007782|UniProtKB=F1PWZ2	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF358	MYOSIN-7B
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	YEAST|SGD=S000001587|UniProtKB=P14742	Glutamine--fructose-6-phosphate aminotransferase [isomerizing]	ISS			PTHR10937:SF0	GH12731P-RELATED
P00034	Integrin signalling pathway	P00948	Rho	MONDO|Ensembl=ENSMODG00000012981|UniProtKB=F7CS91	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	ISS	1650351	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P05918	p38 MAPK pathway	P06026	MEKK4	HUMAN|HGNC=6856|UniProtKB=Q9Y6R4	Mitogen-activated protein kinase kinase kinase 4	IDA	12052864	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00021	FGF signaling pathway	P00647	SHP2	TAKRU|Ensembl=ENSTRUG00000018529|UniProtKB=H2VDZ2	Tyrosine-protein phosphatase non-receptor type	ISS	7681589	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00036	Interleukin signaling pathway	P00996	STAT	MACMU|Ensembl=ENSMMUG00000017527|UniProtKB=F6UMM2	Signal transducer and activator of transcription	ISS	8085155	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	ORYSJ|EnsemblGenome=OS02G0120800|UniProtKB=Q6ZHA3	Rac-like GTP-binding protein 6	ISS	12932731	PubMed	PTHR24072:SF261	SUBFAMILY NOT NAMED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05931	EGR	RAT|RGD=2544|UniProtKB=P08154	Early growth response protein 1	RCA			PTHR44685:SF1	EARLY GROWTH RESPONSE PROTEIN 1
P00057	Wnt signaling pathway	P01472	Histone deacetylase	MOUSE|MGI=MGI=108086|UniProtKB=O09106	Histone deacetylase 1	IDA	12665570	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00052	TGF-beta signaling pathway	P01279	Smurfs	HUMAN|HGNC=16807|UniProtKB=Q9HCE7	E3 ubiquitin-protein ligase SMURF1	TAS	11252892	PubMed	PTHR11254:SF293	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	LEIMA|EnsemblGenome=LmjF.35.4010|UniProtKB=Q9GNR4	Protein kinase A catalytic subunit isoform 1	IC	10218114	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04413	K+ channel	CHICK|Ensembl=ENSGALG00000016193|UniProtKB=E1BYI0	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P05913	Enkephalin release	P05977	G-Protein (s)	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	RAT|RGD=1310141|UniProtKB=D4A4W8	Protein T	ISS	12356903	PubMed	PTHR11267:SF83	BRACHYURY PROTEIN
P00057	Wnt signaling pathway	P01454	betaTrCP	ANOGA|EnsemblGenome=AGAP001944|UniProtKB=Q7PYH7	AGAP001944-PA	ISS	10074433	PubMed	PTHR44038:SF2	F-BOX/WD REPEAT-CONTAINING PROTEIN 1A
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00016	Cytoskeletal regulation by Rho GTPase	P00507	Rho	DAPPU|EnsemblGenome=DAPPUDRAFT_301996|UniProtKB=E9HL06	Putative uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00025	Hedgehog signaling pathway	P00691	CBP	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00036	Interleukin signaling pathway	P00976	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04376	5HT4 type receptor mediated signaling pathway	P04427	5HT4 Receptor	HUMAN|HGNC=5299|UniProtKB=Q13639	5-hydroxytryptamine receptor 4	ISS	15118808	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IGI	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00052	TGF-beta signaling pathway	P01284	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00037	Ionotropic glutamate receptor pathway	P01006	NR2C	MOUSE|MGI=MGI=95822|UniProtKB=Q01098	Glutamate receptor ionotropic, NMDA 2C	ISS	11319238	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00029	Huntington disease	G01532	PolyQ HTT	HUMAN|HGNC=4851|UniProtKB=P42858	Huntingtin	TAS	8268927	PubMed	PTHR10170:SF10	HUNTINGTIN
P02738	De novo purine biosynthesis	P02899	GMP synthase	ECOLI|EcoGene=EG10420|UniProtKB=P04079	GMP synthase [glutamine-hydrolyzing]	ISS			PTHR11922:SF2	GMP SYNTHASE  GLUTAMINE-HYDROLYZING
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04398	p53 pathway feedback loops 2	P04651	Ras	CHICK|Ensembl=ENSGALG00000014033|UniProtKB=E1BTS2	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00049	Parkinson disease	P01211	ERK	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	IDA	11707292	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	22040490	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=1310389|UniProtKB=D3ZTF6	Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Predicted), isoform CRA_a	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00059	p53 pathway	G01565	PERP	MOUSE|MGI=MGI=1929938|UniProtKB=Q9JK95	p53 apoptosis effector related to PMP-22	ISS			PTHR14399:SF4	P53 APOPTOSIS EFFECTOR RELATED TO PMP-22
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	RAT|RGD=67399|UniProtKB=Q64716	Insulin receptor-related protein	ISS	12644000	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00038	JAK/STAT signaling pathway	P01029	Serine kinase	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS			PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00006	Apoptosis signaling pathway	P00318	PKCs	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01087	CAT	MOUSE|MGI=MGI=88392|UniProtKB=Q03059	Choline O-acetyltransferase	IC	92155737	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00034	Integrin signalling pathway	P00931	Integrin beta	MOUSE|MGI=MGI=1277979|UniProtKB=Q3UV74	Integrin beta-2-like protein	IDA	3487386	PubMed	PTHR10082:SF15	INTEGRIN BETA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	PANTR|Ensembl=ENSPTRG00000017612|UniProtKB=C7G3N0	Glutamate receptor, metabotropic 6	ISS			PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P02723	Adenine and hypoxanthine salvage pathway	P02807	Deoxyadenosine deaminase	STRCO|EnsemblGenome=CAC33066|UniProtKB=Q9AK25	Adenosine deaminase 1	ISS			PTHR11409:SF43	ADENOSINE DEAMINASE
P00008	Axon guidance mediated by Slit/Robo	P00344	Netrin	MOUSE|MGI=MGI=1341188|UniProtKB=Q9R1A3	Netrin-3	ISS			PTHR10574:SF292	NETRIN-3
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00019	Endothelin signaling pathway	P00586	Gq	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	1650351	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00060	Ubiquitin proteasome pathway	P01490	E3	RAT|Ensembl=ENSRNOG00000059043|UniProtKB=A0A0G2K9T1	E3 ubiquitin-protein ligase	ISS			PTHR11254:SF66	E3 UBIQUITIN-PROTEIN LIGASE ITCHY HOMOLOG
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01067	AChE	CAEEL|WormBase=WBGene00000038|UniProtKB=G5EDN1	Carboxylic ester hydrolase	IC			PTHR43918:SF2	CARBOXYLIC ESTER HYDROLASE
P00006	Apoptosis signaling pathway	P00269	MAPK	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	HUMAN|HGNC=9509|UniProtKB=P49810	Presenilin-2	TAS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8693|UniProtKB=Q9UN66	Protocadherin beta-8	IDA	8120095	PubMed	PTHR24028:SF150	PROTOCADHERIN BETA-8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00045	Notch signaling pathway	P01118	Numb	MONDO|Ensembl=ENSMODG00000006741|UniProtKB=F7CD96	Uncharacterized protein	ISS	10468633	PubMed	PTHR11232:SF33	PROTEIN NUMB HOMOLOG
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	ARATH|TAIR=AT4G34460|UniProtKB=P49177	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF48	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	TETTS|EnsemblGenome=TTHERM_00575350|UniProtKB=Q22V65	TATA box-binding protein (TBP): present in archaea and protein	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00017	DNA replication	P00530	Top	PANTR|Ensembl=ENSPTRG00000013498|UniProtKB=H2QKC9	Topoisomerase (DNA) I	RCA			PTHR10290:SF5	DNA TOPOISOMERASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	HUMAN|HGNC=1604|UniProtKB=P51677	C-C chemokine receptor type 3	ISS	11830666	PubMed	PTHR10489:SF649	C-C CHEMOKINE RECEPTOR TYPE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04393	Ras Pathway	P04552	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	IDA	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00019	Endothelin signaling pathway	P00570	PKA	NEUCR|EnsemblGenome=EFNCRG00000004240|UniProtKB=Q01386	cAMP-dependent protein kinase regulatory subunit	IGI	176892	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04393	Ras Pathway	P04542	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00786	ARF	BOVIN|Ensembl=ENSBTAG00000016847|UniProtKB=Q0VC18	ADP-ribosylation factor-like protein 4D	ISS	12932731	PubMed	PTHR11711:SF137	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 4D
P00017	DNA replication	P00533	Pol delta	MOUSE|MGI=MGI=1097163|UniProtKB=O35654	DNA polymerase delta subunit 2	ISS	96079106	PubMed	PTHR10416:SF0	DNA POLYMERASE DELTA SUBUNIT 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P06959	CCKR signaling map	P07078	ATF2	HUMAN|HGNC=784|UniProtKB=P15336	Cyclic AMP-dependent transcription factor ATF-2	RCA	12239223	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00059	p53 pathway	P01486	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	TAS	10395542	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	YEAST|SGD=S000001496|UniProtKB=P33204	Actin-related protein 2/3 complex subunit 4	ISS	5031595	gi	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	BOVIN|Ensembl=ENSBTAG00000018204|UniProtKB=Q9BE40	Myosin-1	IEP	10938134	PubMed	PTHR13140:SF484	MYOSIN-1
P00021	FGF signaling pathway	P00629	PP2A	EMENI|EnsemblGenome=CADANIAG00006588|UniProtKB=Q9HFQ2	Serine/threonine-protein phosphatase PP2A catalytic subunit	NAS			PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	STRPU|Gene=CYIIIB|UniProtKB=P18499	Actin, cytoskeletal 3B	IDA	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	TAS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P02776	Serine glycine biosynthesis	P03160	Phosphoglycerate dehydrogenase	THEMA|EnsemblGenome=THEMA_07310|UniProtKB=Q9X1C1	Hydroxypyruvate reductase	ISS			PTHR42938:SF9	FORMATE DEHYDROGENASE 1-RELATED
P00021	FGF signaling pathway	P00624	14-3-3	SCHMA|EnsemblGenome=Smp_034840|UniProtKB=G4V8A9	14-3-3 epsilon	IGI	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P05916	Opioid prodynorphin pathway	P06002	G-protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00936	PI3K	CANAL|CGD=CAL0068551|UniProtKB=Q5AAR9	Phosphatidylinositol 3-kinase	IC	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01435	SWI/SNF	RAT|RGD=69289|UniProtKB=O54772	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2	IDA	11532957	PubMed	PTHR13844:SF2	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D MEMBER 2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00056	VEGF signaling pathway	P01411	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00049	Parkinson disease	P01239	Cul-1	TAKRU|Ensembl=ENSTRUG00000005377|UniProtKB=H2SKH0	Uncharacterized protein	ISS	12628165	PubMed	PTHR11932:SF81	CULLIN-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	MOUSE|MGI=MGI=1920014|UniProtKB=Q8BVP5	Casein kinase I isoform gamma-2	ISS	10617630	PubMed	PTHR11909:SF157	CASEIN KINASE I ISOFORM GAMMA-2
P00049	Parkinson disease	P01208	Hsp70	BOVIN|Ensembl=ENSBTAG00000025441|UniProtKB=Q27975	Heat shock 70 kDa protein 1A	IDA	12150907	PubMed	PTHR19375:SF223	HEAT SHOCK 70 KDA PROTEIN 1A-RELATED
P00018	EGF receptor signaling pathway	P00539	14-3-3	MOUSE|MGI=MGI=1891917|UniProtKB=Q9CQV8	14-3-3 protein beta/alpha	ISS	10407019	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00059	p53 pathway	P01486	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	TAS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	IDA	11707292	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	BOVIN|Ensembl=ENSBTAG00000014710|UniProtKB=P62833	Ras-related protein Rap-1A	ISS	1904317	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00036	Interleukin signaling pathway	P00976	GSK3	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00049	Parkinson disease	P01236	Casein kinase II	MOUSE|MGI=MGI=88543|UniProtKB=Q60737	Casein kinase II subunit alpha	IDA	10617630	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CAEBR|Gene=CBG04581|UniProtKB=A8WXZ5	Protein CBR-GAR-3	ISS	11689554	PubMed	PTHR43914:SF8	MUSCARINIC ACETYLCHOLINE RECEPTOR GAR-3
P02763	Peptidoglycan biosynthesis	P03092	Phospho-N-acetylmuramoyl pentapeptide transferase	AQUAE|EnsemblGenome=aq_053|UniProtKB=O66465	Phospho-N-acetylmuramoyl-pentapeptide-transferase	ISS			PTHR22926:SF5	PHOSPHO-N-ACETYLMURAMOYL-PENTAPEPTIDE-TRANSFERASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00047	PDGF signaling pathway	P01175	Shc	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	ISS	8264585	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00053	T cell activation	P01304	Csk	MOUSE|MGI=MGI=88537|UniProtKB=P41241	Tyrosine-protein kinase CSK	IDA	12665526	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	PSEAE|EnsemblGenome=PA1156|UniProtKB=Q9I4I1	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00006	Apoptosis signaling pathway	P00274	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00017	DNA replication	P00533	Pol delta	MOUSE|MGI=MGI=97741|UniProtKB=P52431	DNA polymerase delta catalytic subunit	ISS	92089082	PubMed	PTHR10322:SF23	DNA POLYMERASE DELTA CATALYTIC SUBUNIT
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	88234494	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	DANRE|ZFIN=ZDB-GENE-040426-2487|UniProtKB=Q803G3	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IGI	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	HUMAN|HGNC=172|UniProtKB=P36896	Activin receptor type-1B	TAS	9395284	PubMed	PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P00018	EGF receptor signaling pathway	P00552	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P05912	Dopamine receptor mediated signaling pathway	P05963	MAO	DANRE|ZFIN=ZDB-GENE-040329-3|UniProtKB=Q6NSN2	Amine oxidase [flavin-containing]	ISS	90344230	PubMed	PTHR43563:SF2	AMINE OXIDASE  FLAVIN-CONTAINING
P02724	Alanine biosynthesis	P02815	Branched chain amino acid aminotransferase	RAT|RGD=2195|UniProtKB=P54690	Branched-chain-amino-acid aminotransferase, cytosolic	ISS			PTHR11825:SF51	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, CYTOSOLIC
P00048	PI3 kinase pathway	P01185	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00029	Huntington disease	P00807	Actin	TRIAD|EnsemblGenome=TriadG56111|UniProtKB=B3RX77	Non-muscle actin 6.2	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00010	B cell activation	P00383	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IDA	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	RAT|RGD=71014|UniProtKB=Q04400	Adenylate cyclase type 5	IGI	93156838	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	DANRE|ZFIN=ZDB-GENE-040718-93|UniProtKB=Q6DGZ5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00023	General transcription regulation	P00662	TFIIA complex	BOVIN|Ensembl=ENSBTAG00000010298|UniProtKB=Q32L01	Transcription initiation factor IIA subunit 2	ISS	95241493	PubMed	PTHR10966:SF0	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00034	Integrin signalling pathway	P00922	Collagen	PANTR|Ensembl=ENSPTRG00000029189|UniProtKB=H2R6I5	Uncharacterized protein	ISS	10778855	PubMed	PTHR44929:SF1	COLLAGEN ALPHA-1 XV  CHAIN
P06216	SCW signaling pathway	P06335	SOG	DROME|FlyBase=FBgn0003463|UniProtKB=Q24025	Dorsal-ventral patterning protein Sog	IDA	16781701	PubMed	PTHR11339:SF357	DORSAL-VENTRAL PATTERNING PROTEIN SOG
P00052	TGF-beta signaling pathway	P01284	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04395	Vasopressin synthesis	P04597	Signal Peptide	DANRE|ZFIN=ZDB-GENE-030407-1|UniProtKB=F1QC27	Uncharacterized protein	ISS	1706187	PubMed	PTHR11681:SF14	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00774	Dynein complex	ASHGO|EnsemblGenome=AGOS_ACR258W|UniProtKB=Q9C1M7	Dynein heavy chain, cytoplasmic	ISS	9454836	PubMed	PTHR10676:SF314	CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01451	Galpha	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00047	PDGF signaling pathway	P01168	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	BOVIN|Ensembl=ENSBTAG00000014828|UniProtKB=F1N1E0	Uncharacterized protein	ISS	11976940	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00047	PDGF signaling pathway	P01175	Shc	RAT|RGD=1307137|UniProtKB=O70142	SHC-transforming protein 2	ISS	600560	OMIM	PTHR10337:SF5	SHC-TRANSFORMING PROTEIN 2
P00049	Parkinson disease	P01230	Src kinase	MACMU|Ensembl=ENSMMUG00000014149|UniProtKB=F7BV42	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P00059	p53 pathway	G04700	PAI	PANTR|Ensembl=ENSPTRG00000019519|UniProtKB=H2QV47	Uncharacterized protein	ISS	10692390	PubMed	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04393	Ras Pathway	P04567	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00047	PDGF signaling pathway	P01174	Rho	MOUSE|MGI=MGI=109605|UniProtKB=Q91Z67	SLIT-ROBO Rho GTPase-activating protein 2	ISS			PTHR14166:SF6	SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 2-RELATED
P04393	Ras Pathway	P04541	p90RSK	MONDO|Ensembl=ENSMODG00000008086|UniProtKB=F6YJ34	Ribosomal protein S6 kinase	ISS	10558991	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	HUMAN|HGNC=4580|UniProtKB=Q13002	Glutamate receptor ionotropic, kainate 2	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P05731	GABA-B receptor II signaling	P05754	Ggamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00004	Alzheimer disease-presenilin pathway	P00114	actin	HUMAN|HGNC=17780|UniProtKB=Q562R1	Beta-actin-like protein 2	IDA	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00052	TGF-beta signaling pathway	G01548	I-SMAD	MACMU|Ensembl=ENSMMUG00000012770|UniProtKB=F7EIP8	Mothers against decapentaplegic homolog	ISS	9335505	PubMed	PTHR13703:SF27	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 7
P00047	PDGF signaling pathway	P01145	c-fos	MACMU|Ensembl=ENSMMUG00000010574|UniProtKB=A5A6H2	C-fos	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00034	Integrin signalling pathway	P00924	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	2372396	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04541	p90RSK	PANTR|Ensembl=ENSPTRG00000000387|UniProtKB=H2PYE3	Ribosomal protein S6 kinase	ISS	12213813	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IDA	7925653	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P06664	Gonadotropin-releasing hormone receptor pathway	P06811	SRF	MOUSE|MGI=MGI=106658|UniProtKB=Q9JM73	Serum response factor	RCA	8660892	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00009	Axon guidance mediated by netrin	P00357	Netrin	RAT|RGD=619809|UniProtKB=Q924Z9	Netrin-1	IEP	11356879	PubMed	PTHR10574:SF365	NETRIN-1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	HUMAN|HGNC=16889|UniProtKB=O00487	26S proteasome non-ATPase regulatory subunit 14	ISS	9727008	PubMed	PTHR10410:SF5	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 14
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	MONDO|Ensembl=ENSMODG00000004411|UniProtKB=F6SV50	Receptor protein serine/threonine kinase	ISS			PTHR23255:SF58	ACTIVIN RECEPTOR TYPE-1C
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00005	Angiogenesis	P00223	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00260	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	PANTR|Ensembl=ENSPTRG00000031262|UniProtKB=H2RAB4	Uncharacterized protein	ISS	11248120	PubMed	PTHR43893:SF8	D 1B  DOPAMINE RECEPTOR
P00053	T cell activation	P01311	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P04393	Ras Pathway	P04566	Stat 1/3	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	RCA	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00059	p53 pathway	G04702	p53	ORNAN|Ensembl=ENSOANG00000013795|UniProtKB=F7DUR2	Uncharacterized protein (Fragment)	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MACMU|Ensembl=ENSMMUG00000023290|UniProtKB=F6ZBU9	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF151	EMBRYONIC GROWTH/DIFFERENTIATION FACTOR 1
P00029	Huntington disease	P00790	beta-Tubulin	STRPU|EnsemblGenome=SPU_013273|UniProtKB=W4YBZ7	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	ORNAN|Ensembl=ENSOANG00000004058|UniProtKB=F6TYP9	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00054	Toll receptor signaling pathway	P01348	A20	HUMAN|HGNC=11896|UniProtKB=P21580	Tumor necrosis factor alpha-induced protein 3	ISS			PTHR13367:SF3	TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 3
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	IDA	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00036	Interleukin signaling pathway	P00965	ERK	HUMAN|HGNC=6880|UniProtKB=Q13164	Mitogen-activated protein kinase 7	IC	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00018	EGF receptor signaling pathway	P00562	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00056	VEGF signaling pathway	P01411	Ras	BOVIN|Ensembl=ENSBTAG00000009778|UniProtKB=E1BMX0	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000018051|UniProtKB=F7ER09	Uncharacterized protein	ISS	8120095	PubMed	PTHR24026:SF42	PROTOCADHERIN FAT 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00965	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IGI	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00018	EGF receptor signaling pathway	P00545	JNK1-3	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00045	Notch signaling pathway	P01104	Serrate	CANLF|Ensembl=ENSCAFG00000005627|UniProtKB=E2QUR0	Delta-like protein	ISS	8955070	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	RAT|RGD=620314|UniProtKB=B0LPN4	Ryanodine receptor 2	ISS	15858232	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	RAT|RGD=71027|UniProtKB=P42264	Glutamate receptor ionotropic, kainate 3	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CHICK|Ensembl=ENSGALG00000011809|UniProtKB=F1NMB0	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00021	FGF signaling pathway	P00646	RasGAP	PANTR|Ensembl=ENSPTRG00000019540|UniProtKB=H2R524	Uncharacterized protein	ISS	6635197	gi	PTHR10194:SF4	RAS GTPASE-ACTIVATING PROTEIN 4-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1203729|UniProtKB=Q61194	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P04393	Ras Pathway	P04552	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IDA	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00020	FAS signaling pathway	P00615	JNK	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	TAS	10207617	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00047	PDGF signaling pathway	P01150	PKC	MACMU|Ensembl=ENSMMUG00000020588|UniProtKB=F7C0E0	Uncharacterized protein	ISS	11880265	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	ANOGA|EnsemblGenome=AGAP005912|UniProtKB=Q7Q6D3	AGAP005912-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	MOUSE|MGI=MGI=2442252|UniProtKB=Q8VI56	Low-density lipoprotein receptor-related protein 4	IDA	11907044	PubMed	PTHR44017:SF4	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	12657601	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	TAKRU|Ensembl=ENSTRUG00000005608|UniProtKB=H2SM93	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	TAS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	TAS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=104692|UniProtKB=F7BJK1	Protein Pcdh1 (Fragment)	ISS	8120095	PubMed	PTHR43912:SF3	PROTOCADHERIN-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=2685045|UniProtKB=E9QAN8	Protein Pik3c2b	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	RAT|RGD=3187|UniProtKB=Q07008	Neurogenic locus notch homolog protein 1	IDA	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00015	Circadian clock system	P00505	Cry	DANRE|ZFIN=ZDB-GENE-010426-4|UniProtKB=B0S7X5	Uncharacterized protein	ISS			PTHR11455:SF10	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00053	T cell activation	P01307	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=2144613|UniProtKB=Q3U6Q4	Phosphoinositide 3-kinase regulatory subunit 6	ISS			PTHR15593:SF1	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 6
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ARATH|TAIR=AT5G45620|UniProtKB=Q8RWF0	26S proteasome non-ATPase regulatory subunit 13 homolog A	ISS			PTHR10539:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	IDA	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00577	PI3K	DANRE|ZFIN=ZDB-GENE-040309-1|UniProtKB=B3DHG9	Pik3r2 protein	ISS			PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00005	Angiogenesis	P00244	MAPKAPK2/3	PANTR|Ensembl=ENSPTRG00000001915|UniProtKB=H2Q104	Mitogen-activated protein kinase-activated protein kinase 2	ISS	10779545	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	BOVIN|Ensembl=ENSBTAG00000018445|UniProtKB=E1BK87	Uncharacterized protein	ISS	11554549	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00025	Hedgehog signaling pathway	P00682	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	10074940	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P05730	Endogenous cannabinoid signaling	P05748	mGluR	RAT|RGD=2746|UniProtKB=P31424	Metabotropic glutamate receptor 5	ISS	12351712	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00642	MEK1-2	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IGI	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	CANLF|Ensembl=ENSCAFG00000000415|UniProtKB=E2R2K4	Uncharacterized protein	ISS	10476970	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	DROME|FlyBase=FBgn0001991|UniProtKB=Q24270	Voltage-dependent calcium channel type D subunit alpha-1	ISS	11956331	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00048	PI3 kinase pathway	P01192	p110	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05918	p38 MAPK pathway	P06020	p38delta	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04586	ProTRH (Pro Thyrotropin-releasing Hormone)	MACMU|Ensembl=ENSMMUG00000009962|UniProtKB=F6RBM2	Thyroid stimulating hormone beta subunit	ISS			PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P00029	Huntington disease	P00798	Clathrin	PANTR|Ensembl=ENSPTRG00000020930|UniProtKB=H2QX95	Uncharacterized protein	ISS	9388255	PubMed	PTHR10639:SF1	CLATHRIN LIGHT CHAIN A
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CAEEL|WormBase=WBGene00001680|UniProtKB=Q20636	Guanine nucleotide-binding protein subunit beta-2	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P06664	Gonadotropin-releasing hormone receptor pathway	P06710	Junc	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	RCA	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00010	B cell activation	P00381	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04397	p53 pathway by glucose deprivation	P04639	AMPK	CHICK|Ensembl=ENSGALG00000010826|UniProtKB=Q2LAI0	5'-AMP-activated protein kinase alpha-2 catalytic subunit	ISS			PTHR24343:SF303	5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-2
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	CHICK|Ensembl=ENSGALG00000007509|UniProtKB=F1NM72	Uncharacterized protein	ISS	6309844	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00053	T cell activation	P01331	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00029	Huntington disease	P00805	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IDA	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	ORNAN|Ensembl=ENSOANG00000014753|UniProtKB=F7EPN2	Uncharacterized protein (Fragment)	ISS	15489039	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00046	Oxidative stress response	P01135	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000001384|UniProtKB=F7GL73	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	PANTR|Ensembl=ENSPTRG00000011049|UniProtKB=H2QGF9	Glycogen synthase kinase 3 alpha	ISS	21361340	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	CAEEL|WormBase=WBGene00001613|UniProtKB=Q10914	Glutamate receptor 2	ISS	http://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF270	GLUTAMATE RECEPTOR 1-RELATED
P00047	PDGF signaling pathway	P01142	p90RSK	CHICK|Ensembl=ENSGALG00000016406|UniProtKB=F1NLJ3	Uncharacterized protein	ISS	2779569	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IGI	3045562	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04393	Ras Pathway	P04544	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	4504111	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P05915	Opioid proenkephalin pathway	P05995	proenkephalin	MOUSE|MGI=MGI=104629|UniProtKB=P22005	Proenkephalin-A	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00010	B cell activation	P00398	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02741	Flavin biosynthesis	P02935	GTP cyclohydrolase	DEIRA|EnsemblGenome=DR_0155|UniProtKB=Q9RXZ9	Riboflavin biosynthesis protein RibBA	ISS			PTHR21327:SF32	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00206	Wnt	TAKRU|Ensembl=ENSTRUG00000011562|UniProtKB=H2TX02	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MOUSE|MGI=MGI=1346089|UniProtKB=O54829	Regulator of G-protein signaling 7	IDA	8756726	PubMed	PTHR10845:SF26	REGULATOR OF G-PROTEIN SIGNALING 7
P02774	Salvage pyrimidine deoxyribonucleotides	P03147	Thymidine kinase	HALSA|EnsemblGenome=VNG_1515G|UniProtKB=Q9HPQ9	Thymidine kinase	ISS			PTHR11441:SF0	THYMIDINE KINASE, CYTOSOLIC
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00018	EGF receptor signaling pathway	P00562	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00052	TGF-beta signaling pathway	P01286	TGFbeta	TAKRU|Ensembl=ENSTRUG00000000132|UniProtKB=H2RJF7	Uncharacterized protein (Fragment)	ISS	9759503	PubMed	PTHR11848:SF235	GROWTH DIFFERENTIATION FACTOR 8, LIKE-RELATED
P00059	p53 pathway	P01486	Akt	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	TAS	12089061	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05918	p38 MAPK pathway	P06021	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	CANLF|Ensembl=ENSCAFG00000011625|UniProtKB=F1PDD9	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	ARATH|TAIR=AT5G63310|UniProtKB=O64903	Nucleoside diphosphate kinase II, chloroplastic	ISS			PTHR11349:SF44	NUCLEOSIDE DIPHOSPHATE KINASE II, CHLOROPLASTIC
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PHYPA|Gene=PHYPADRAFT_186458|UniProtKB=Q6TYR7	Beta-tubulin 1	ISS	9454836	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01185	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	MOUSE|MGI=MGI=1349182|UniProtKB=P86792	C-C motif chemokine 21b	ISS			PTHR12015:SF72	C-C MOTIF CHEMOKINE 21
P06664	Gonadotropin-releasing hormone receptor pathway	P06757	JUN	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	RCA	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00036	Interleukin signaling pathway	P00977	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IC	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00047	PDGF signaling pathway	P01143	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02770	Pyridoxal phosphate salvage pathway	P03123	Pyridoxine-5-phosphate oxidase	MOUSE|MGI=MGI=2144151|UniProtKB=Q91XF0	Pyridoxine-5'-phosphate oxidase	ISS	14697241	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00036	Interleukin signaling pathway	P00968	Ikk	MACMU|Ensembl=ENSMMUG00000018476|UniProtKB=F6X938	Uncharacterized protein	ISS	12813046	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00260	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00627	ERK1-2	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	HUMAN|HGNC=11333|UniProtKB=P31391	Somatostatin receptor type 4	IDA			PTHR24229:SF52	SOMATOSTATIN RECEPTOR TYPE 4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00023	General transcription regulation	P00658	TBP-associated factors	DROME|FlyBase=FBgn0002842|UniProtKB=Q9VP40	Spermatocyte arrest	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00025	Hedgehog signaling pathway	P00691	CBP	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	PANTR|Ensembl=ENSPTRG00000002979|UniProtKB=H2Q2M8	Uncharacterized protein	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00048	PI3 kinase pathway	P01176	JAK	CANLF|Ensembl=ENSCAFG00000002102|UniProtKB=E2RPW6	Tyrosine-protein kinase	ISS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01199	Galpha	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00020	FAS signaling pathway	P00615	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04393	Ras Pathway	P04542	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	HUMAN|HGNC=16767|UniProtKB=Q8TCU5	Glutamate receptor ionotropic, NMDA 3A	ISS	11554549	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00047	PDGF signaling pathway	P01160	IP3 receptor	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008026|UniProtKB=H2QAZ2	Syntaxin 1B	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02738	De novo purine biosynthesis	P02903	Phosphoribosylglycinamide  formyltransferase	MYCTU|EnsemblGenome=Rv0956|UniProtKB=P9WHM5	Phosphoribosylglycinamide formyltransferase	ISS			PTHR43369:SF2	PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MACMU|Ensembl=ENSMMUG00000031972|UniProtKB=F7GWC3	Actin-related protein 2/3 complex subunit 4	ISS	5031595	gi	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	ORYSJ|EnsemblGenome=OS05G0491100|UniProtKB=Q6F332	Calmodulin-2	ISS	9753452	PubMed	PTHR23050:SF324	CALMODULIN-2-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00052	TGF-beta signaling pathway	P01275	P38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00010	B cell activation	P00399	Ig-alpha	HUMAN|HGNC=1698|UniProtKB=P11912	B-cell antigen receptor complex-associated protein alpha chain	IDA	2023945	PubMed	PTHR14334:SF1	B-CELL ANTIGEN RECEPTOR COMPLEX-ASSOCIATED PROTEIN ALPHA CHAIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00057	Wnt signaling pathway	P01444	Wnt	BOVIN|Ensembl=ENSBTAG00000013990|UniProtKB=F1MN70	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	8327893	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00021	FGF signaling pathway	P00631	Grb2	CAEBR|Gene=CBG16856|UniProtKB=A8XPY6	Protein CBR-SEM-5	ISS	11457149	PubMed	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CANLF|Gene=DRD2|UniProtKB=Q9GJU1	D(2) dopamine receptor	IDA	2039532	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PHYPA|Gene=PHYPADRAFT_225906|UniProtKB=A9TVP1	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P06664	Gonadotropin-releasing hormone receptor pathway	P06850	PKCs(3)	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	RCA	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02738	De novo purine biosynthesis	P02905	Amidophosphoribosyl transferase	DROME|FlyBase=FBgn0004901|UniProtKB=Q27601	Amidophosphoribosyltransferase	ISS			PTHR11907:SF18	AMIDOPHOSPHORIBOSYLTRANSFERASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01452	NFAT	PANTR|Ensembl=ENSPTRG00000006218|UniProtKB=H2Q834	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	RAT|RGD=2736|UniProtKB=P35439	Glutamate receptor ionotropic, NMDA 1	IC	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00010	B cell activation	P00379	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00020	FAS signaling pathway	P00615	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04568	MKK3/6	RAT|RGD=1306620|UniProtKB=B1H230	Map2k3 protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00048	PI3 kinase pathway	G01545	scl-1	CAEEL|WormBase=WBGene00009892|UniProtKB=Q93746	SCP-Like extracellular protein	ISS			PTHR10334:SF325	SCP-LIKE EXTRACELLULAR PROTEIN
P02766	Phenylethylamine degradation	P03103	Phenylethylamine oxidase	MACMU|Ensembl=ENSMMUG00000001870|UniProtKB=F7GP69	Amine oxidase	ISS			PTHR10638:SF4	RETINA-SPECIFIC COPPER AMINE OXIDASE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	94280860	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	CANLF|Ensembl=ENSCAFG00000000760|UniProtKB=E2R9L4	Uncharacterized protein	ISS	602425	OMIM	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00001	Adrenaline and noradrenaline biosynthesis	P00068	amine translocator	MONDO|Ensembl=ENSMODG00000001744|UniProtKB=F6WZU5	Transporter	ISS	12719981	PubMed	PTHR11616:SF102	SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER SLC6A17
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CANLF|Ensembl=ENSCAFG00000029321|UniProtKB=J9P5H0	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00052	TGF-beta signaling pathway	P01275	P38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	12810719	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00029	Huntington disease	P00781	Dynactin	NEUCR|EnsemblGenome=EFNCRG00000002612|UniProtKB=Q01397	Dynactin, 150 kDa isoform	IPI	9454836	PubMed	PTHR18916:SF6	DYNACTIN SUBUNIT 1
P02759	Pyridoxal-5-phosphate biosynthesis	P03058	Phosphohydroxythreonine aminotransferase	DROME|FlyBase=FBgn0014427|UniProtKB=Q9VAN0	Probable phosphoserine aminotransferase	ISS			PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IPI	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01408	Akt/PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01407	Erk	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	97442349	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	IC	9166716	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00005	Angiogenesis	P00203	Erk	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00148	Erb-B4 N-terminal fragment	MONDO|Ensembl=ENSMODG00000015755|UniProtKB=F6ZSZ9	Uncharacterized protein (Fragment)	ISS	4884676	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00053	T cell activation	P01324	rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ANOGA|EnsemblGenome=AGAP001676|UniProtKB=Q7PXZ8	AGAP001676-PA	ISS	14684598	PubMed	PTHR11937:SF368	ACTIN, INDIRECT FLIGHT MUSCLE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	SCHPO|PomBase=SPAC26A3.05|UniProtKB=Q10161	Probable clathrin heavy chain	IDA	9388255	PubMed	PTHR10292:SF1	CLATHRIN HEAVY CHAIN
P00045	Notch signaling pathway	P01104	Serrate	MACMU|Ensembl=ENSMMUG00000001276|UniProtKB=F7BUF3	Delta-like protein	ISS			PTHR44097:SF1	PROTEIN JAGGED-2
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00193	SOS-1	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IDA	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P06215	MYO signaling pathway	P06309	LACK	DROME|FlyBase=FBgn0029006|UniProtKB=Q9V853	E3 ubiquitin-protein ligase Smurf1	IEA	http://flybase.org/reports/FBgn0029006.html	Website	PTHR11254:SF395	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00024	Glycolysis	P00677	Hexokinase	RAT|RGD=2321830|UniProtKB=M0R3X7	Protein LOC100364027	RCA			PTHR19443:SF28	HEXOKINASE HKDC1-RELATED
P00056	VEGF signaling pathway	P01409	cPLA2	RAT|RGD=67366|UniProtKB=P50393	Cytosolic phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00005	Angiogenesis	P00223	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00017	DNA replication	P00529	RFC	RAT|RGD=1309280|UniProtKB=B5DF29	Protein Rfc5	RCA			PTHR11669:SF9	REPLICATION FACTOR C SUBUNIT 5
P02736	Coenzyme A biosynthesis	P02885	Pantothenate kinase	ARATH|TAIR=AT4G35360|UniProtKB=Q8W4Q1	At4g35360/F23E12_80	ISS			PTHR12280:SF31	SUBFAMILY NOT NAMED
P00012	Cadherin signaling pathway	P00465	TCF/LEF	XENTR|Xenbase=XB-GENE-1031985|UniProtKB=Q6GL68	Transcription factor 7-like 1	ISS	11266476	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P02733	Carnitine metabolism	P02866	Carnitine dehydratase	MACMU|Ensembl=ENSMMUG00000001702|UniProtKB=F7FZV9	Uncharacterized protein	ISS			PTHR43949:SF6	SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	HUMAN|HGNC=29523|UniProtKB=Q9Y6A4	Cilia- and flagella-associated protein 20	ISS			PTHR12458:SF8	CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=621089|UniProtKB=F1LMI3	Cadherin 3, type 1, P-cadherin (Placental)	ISS	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	ANOGA|EnsemblGenome=AGAP001394|UniProtKB=F5HMS4	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	HUMAN|HGNC=8926|UniProtKB=P46019	Phosphorylase b kinase regulatory subunit alpha, liver isoform	IDA	10487978	PubMed	PTHR10749:SF5	PHOSPHORYLASE B KINASE REGULATORY SUBUNIT ALPHA, LIVER ISOFORM
P00029	Huntington disease	P00778	NMDA receptor	CAEBR|Gene=CBG02401|UniProtKB=A8WUE7	Protein CBR-NMR-1	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00021	FGF signaling pathway	P00641	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	RAT|RGD=1565398|UniProtKB=D3ZUL3	Protein Col6a1	ISS	10778855	PubMed	PTHR44172:SF3	COLLAGEN ALPHA-1 VI  CHAIN
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	EMENI|EnsemblGenome=CADANIAG00006296|UniProtKB=Q5ASG1	Putative synaptobrevin homologue SNC1/2 (Eurofung)	ISS			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00047	PDGF signaling pathway	P01171	PLCgamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05918	p38 MAPK pathway	P06024	eIF4E	MACMU|Ensembl=ENSMMUG00000011066|UniProtKB=F7GKR8	Uncharacterized protein	ISS			PTHR11960:SF14	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00944	Actin	PANTR|Ensembl=ENSPTRG00000018890|UniProtKB=Q5R1X3	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00049	Parkinson disease	P01227	20S proteasome	MOUSE|MGI=MGI=1347009|UniProtKB=Q9Z2U1	Proteasome subunit alpha type-5	TAS	12859888	PubMed	PTHR11599:SF14	PROTEASOME SUBUNIT ALPHA TYPE-5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	MONDO|Ensembl=ENSMODG00000012981|UniProtKB=F7CS91	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	IGI	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P05913	Enkephalin release	P05972	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05915	Opioid proenkephalin pathway	P05994	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DANRE|ZFIN=ZDB-GENE-040625-35|UniProtKB=Q6IQL9	Novel actin protein	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00049	Parkinson disease	P01227	20S proteasome	RAT|RGD=1564425|UniProtKB=D3Z8J0	Protein RGD1564425	TAS	12859888	PubMed	PTHR11599:SF62	PROTEASOME SUBUNIT BETA TYPE-3
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00011	Blood coagulation	P00408	Plasminogen	MACMU|Gene=PLG|UniProtKB=P12545	Plasminogen	ISS	4505881	gi	PTHR24261:SF6	PLASMINOGEN
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00995	c-Myc	MACMU|Ensembl=ENSMMUG00000014601|UniProtKB=B8XIA5	Myc proto-oncogene protein	ISS	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00021	FGF signaling pathway	P00648	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BOVIN|Ensembl=ENSBTAG00000005714|UniProtKB=Q3ZC07	Actin, alpha cardiac muscle 1	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00632	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MOUSE|MGI=MGI=2443573|UniProtKB=P57785	Left-right determination factor 2	TAS	9759503	PubMed	PTHR11848:SF175	LEFT-RIGHT DETERMINATION FACTOR 2
P00005	Angiogenesis	P00206	Wnt	DROME|FlyBase=FBgn0004009|UniProtKB=P09615	Protein wingless	ISS	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00025	Hedgehog signaling pathway	P00692	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	PHYPA|Gene=PHYPADRAFT_218038|UniProtKB=A9T1P2	Predicted protein	ISS			PTHR23073:SF13	26S PROTEASE REGULATORY SUBUNIT 7
P00018	EGF receptor signaling pathway	P00555	MKK4,7	MACMU|Ensembl=ENSMMUG00000019842|UniProtKB=F7FU91	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CHICK|Ensembl=ENSGALG00000008591|UniProtKB=E1BZF6	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	HUMAN|HGNC=6026|UniProtKB=P25024	C-X-C chemokine receptor type 1	ISS	4504683	gi	PTHR10489:SF916	C-X-C CHEMOKINE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00633	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00022	General transcription by RNA polymerase I	P00657	TBP	MACMU|Ensembl=ENSMMUG00000009889|UniProtKB=F6YKC3	Uncharacterized protein	ISS			PTHR15938:SF0	HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG
P00049	Parkinson disease	P01211	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	20331588	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00055	Transcription regulation by bZIP transcription factor	P01398	TFIIEalpha	MACMU|Ensembl=ENSMMUG00000001596|UniProtKB=F7GV34	General transcription factor IIE subunit 1	ISS	92065982	PubMed	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	MOUSE|MGI=MGI=87902|UniProtKB=P68134	Actin, alpha skeletal muscle	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00036	Interleukin signaling pathway	P00983	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00391	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P02763	Peptidoglycan biosynthesis	P03087	Glutamate racemase	BACTN|EnsemblGenome=BT_3722|UniProtKB=Q8A1E4	Glutamate racemase	ISS			PTHR21198:SF2	GLUTAMATE RACEMASE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	BOVIN|Ensembl=ENSBTAG00000016662|UniProtKB=F1ML89	Uncharacterized protein	ISS			PTHR11405:SF38	CARBAMOYL-PHOSPHATE SYNTHASE  AMMONIA , MITOCHONDRIAL
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	TAKRU|Ensembl=ENSTRUG00000017773|UniProtKB=H2V8M1	Uncharacterized protein (Fragment)	IDA	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	MOUSE|MGI=MGI=108100|UniProtKB=Q61062	Segment polarity protein dishevelled homolog DVL-3	TAS	11212302	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P00004	Alzheimer disease-presenilin pathway	P00121	CD44 intracellular fragment	MACMU|Ensembl=ENSMMUG00000004327|UniProtKB=F6ZDZ8	Uncharacterized protein	ISS	14871815	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P00052	TGF-beta signaling pathway	P01286	TGFbeta	XENTR|Xenbase=XB-GENE-485379|UniProtKB=Q28BW9	Novel protein similar to anti-dorsalizing morphogenic protein	ISS	8575329	PubMed	PTHR11848:SF169	ANTI-DORSALIZING MORPHOGENETIC PROTEIN
P05730	Endogenous cannabinoid signaling	P05751	Galpha	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	CANLF|Ensembl=ENSCAFG00000007782|UniProtKB=F1PWZ2	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF358	MYOSIN-7B
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	XENTR|Xenbase=XB-GENE-494548|UniProtKB=F7EC26	Uncharacterized protein	ISS	20362513	PubMed	PTHR24070:SF186	GTPASE KRAS
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00049	Parkinson disease	P01239	Cul-1	DANRE|ZFIN=ZDB-GENE-030131-2603|UniProtKB=Q6NYS3	Cullin 1a	ISS	12628165	PubMed	PTHR11932:SF81	CULLIN-1
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00010	B cell activation	P00379	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00009	Axon guidance mediated by netrin	P00359	NFAT	HUMAN|HGNC=7777|UniProtKB=Q12968	Nuclear factor of activated T-cells, cytoplasmic 3	IDA	9133421	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00029	Huntington disease	P00790	beta-Tubulin	DANRE|ZFIN=ZDB-GENE-040426-2879|UniProtKB=Q6IQJ2	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00018	EGF receptor signaling pathway	P00551	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	IGI	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01423	p38MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05916	Opioid prodynorphin pathway	P06002	G-protein	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00005	Angiogenesis	P00182	p38MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00045	Notch signaling pathway	P01103	Next	ORNAN|Ensembl=ENSOANG00000008425|UniProtKB=F6VUQ4	Delta-like protein	ISS	1286675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	CANLF|Ensembl=ENSCAFG00000016388|UniProtKB=F6X9W7	Protein-serine/threonine kinase	ISS	12032308	PubMed	PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00193	SOS-1	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00018	EGF receptor signaling pathway	P00564	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	10891487	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IDA	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00752	cGMP-gated ion channel	MACMU|Ensembl=ENSMMUG00000005764|UniProtKB=F6W1I8	Uncharacterized protein	ISS	12432397	PubMed	PTHR10217:SF387	CYCLIC NUCLEOTIDE-GATED CHANNEL ROD PHOTORECEPTOR SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	HUMAN|HGNC=3373|UniProtKB=Q09472	Histone acetyltransferase p300	TAS	10823891	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P02736	Coenzyme A biosynthesis	P02885	Pantothenate kinase	PANTR|Ensembl=ENSPTRG00000017509|UniProtKB=H2QRZ1	Pantothenate kinase 3	ISS			PTHR12280:SF21	PANTOTHENATE KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	PANTR|Ensembl=ENSPTRG00000003983|UniProtKB=H2Q4A0	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00021	FGF signaling pathway	P00629	PP2A	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00807	Actin	CIOIN|Ensembl=ENSCING00000000848|UniProtKB=F6SCP4	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00010	B cell activation	P00371	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00367	NFAT	BOVIN|Ensembl=ENSBTAG00000004368|UniProtKB=F1MSU2	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT1G59580|UniProtKB=Q39022	Mitogen-activated protein kinase 2	ISS	94177172	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	PANTR|Ensembl=ENSPTRG00000001144|UniProtKB=H2PZR0	Uncharacterized protein	ISS	5101174	PubMed	PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P00049	Parkinson disease	P01224	UbcH7	MACMU|Ensembl=ENSMMUG00000018994|UniProtKB=F6XWT0	Uncharacterized protein	RCA			PTHR24068:SF67	UBIQUITIN-CONJUGATING ENZYME E2 L3
P00023	General transcription regulation	P00658	TBP-associated factors	XENTR|Xenbase=XB-GENE-5774698|UniProtKB=F6STP6	Uncharacterized protein (Fragment)	ISS			PTHR10221:SF12	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6
P00055	Transcription regulation by bZIP transcription factor	P01396	TFIIFbeta	BOVIN|Ensembl=ENSBTAG00000034495|UniProtKB=Q2T9L9	General transcription factor IIF subunit 2	ISS			PTHR10445:SF0	GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000007882|UniProtKB=G3X7Z2	Uncharacterized protein	ISS	15079861	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00019	Endothelin signaling pathway	P00566	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05918	p38 MAPK pathway	P06034	MKK4	MONDO|Ensembl=ENSMODG00000008266|UniProtKB=F6Z879	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	10395542	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176910	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00474	Wnt	MONDO|Ensembl=ENSMODG00000010644|UniProtKB=F7D4J8	Protein Wnt (Fragment)	ISS	8717036	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00049	Parkinson disease	P01241	TH	MACMU|Ensembl=ENSMMUG00000003912|UniProtKB=F6ZV38	Uncharacterized protein	ISS	191290	OMIM	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	RAT|RGD=71031|UniProtKB=Q06486	Casein kinase I isoform delta	IDA	11437445	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00057	Wnt signaling pathway	P01438	PP2A	CHICK|Ensembl=ENSGALG00000009828|UniProtKB=E1C5A3	Uncharacterized protein	ISS	12110603	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00543	ERK1-2	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	IGI	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P02738	De novo purine biosynthesis	P02894	IMP cyclohydrolase	SYNY3|EnsemblGenome=BAA18861|UniProtKB=P74741	Bifunctional purine biosynthesis protein PurH	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00021	FGF signaling pathway	P00629	PP2A	CHICK|Ensembl=ENSGALG00000010273|UniProtKB=P48463	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	RAT|RGD=621515|UniProtKB=P61954	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	ISS			PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00590	IP3 R	CAEBR|Gene=CBG_05938|UniProtKB=H8WGV2	Protein CBR-ITR-1, isoform a	ISS	9065779	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00053	T cell activation	P01316	MHC-antigen	HUMAN|HGNC=4934|UniProtKB=P28067	HLA class II histocompatibility antigen, DM alpha chain	IPI	73139	PubMed	PTHR19944:SF50	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DM ALPHA CHAIN
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IPI	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IC	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00038	JAK/STAT signaling pathway	P01027	STAT	HUMAN|HGNC=11362|UniProtKB=P42224	Signal transducer and activator of transcription 1-alpha/beta	ISS	15825084	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	RAT|RGD=621515|UniProtKB=P61954	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	ISS	2122451	PubMed	PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	DANRE|ZFIN=ZDB-GENE-051202-2|UniProtKB=Q6ZM67	Uncharacterized protein	ISS	11319238	PubMed	PTHR44391:SF3	SUBFAMILY NOT NAMED
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	MACMU|Ensembl=ENSMMUG00000018533|UniProtKB=F7A202	Uncharacterized protein	ISS			PTHR43570:SF6	ALDEHYDE DEHYDROGENASE FAMILY 3 MEMBER B2
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	PANTR|Ensembl=ENSPTRG00000004718|UniProtKB=H2Q5I0	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	RCA	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	BRAFL|Gene=BRAFLDRAFT_128184|UniProtKB=C4A0B6	Tyrosine-protein kinase receptor	ISS	249616	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00036	Interleukin signaling pathway	P00996	STAT	CANLF|Ensembl=ENSCAFG00000000163|UniProtKB=F1PAY3	Signal transducer and activator of transcription	ISS	8085155	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P02752	Mannose metabolism	P03019	P-Mannose mutase	MACMU|Ensembl=ENSMMUG00000022714|UniProtKB=F7GKX1	Phosphomannomutase	ISS	11042159	PubMed	PTHR10466:SF2	PHOSPHOMANNOMUTASE 2
P00010	B cell activation	P00383	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	IDA	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00053	T cell activation	P01309	fos	CANLF|Ensembl=ENSCAFG00000017040|UniProtKB=E2QYK5	Uncharacterized protein	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	TAKRU|Ensembl=ENSTRUG00000014798|UniProtKB=H2ULI5	Uncharacterized protein	ISS	9043084	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00183	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	7798194	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00029	Huntington disease	P00775	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05913	Enkephalin release	P05972	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00053	T cell activation	P01333	cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00053	T cell activation	P01307	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01154	Ras	MACMU|Ensembl=ENSMMUG00000010460|UniProtKB=F7BP34	Ras-related and estrogen-regulated growth inhibitor	ISS			PTHR24070:SF373	RAS-RELATED AND ESTROGEN-REGULATED GROWTH INHIBITOR
P00009	Axon guidance mediated by netrin	P00363	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00046	Oxidative stress response	P01135	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	TAS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00036	Interleukin signaling pathway	P00973	PKB	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01412	HSP27	PANTR|Ensembl=ENSPTRG00000004274|UniProtKB=H2Q4R8	Uncharacterized protein	ISS			PTHR11527:SF37	ALPHA-CRYSTALLIN B CHAIN
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	HUMAN|HGNC=2453|UniProtKB=P49674	Casein kinase I isoform epsilon	IDA	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	PYRAE|EnsemblGenome=PAE2481|UniProtKB=Q8ZV30	Acetyl-coenzyme A synthetase	ISS			PTHR24095:SF14	ACETYL-COENZYME A SYNTHETASE 1
P00005	Angiogenesis	P00219	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	TAS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01199	Galpha	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	BOVIN|Ensembl=ENSBTAG00000021691|UniProtKB=Q17QP9	Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14	ISS	9727008	PubMed	PTHR10410:SF5	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 14
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IC	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00057	Wnt signaling pathway	P01449	Nemo-like Kinase	BOVIN|Gene=NLK|UniProtKB=E1BMN8	Serine/threonine-protein kinase NLK	ISS	10683140	PubMed	PTHR24055:SF179	SERINE/THREONINE-PROTEIN KINASE NLK
P00053	T cell activation	P01315	Calcineurin	MONDO|Ensembl=ENSMODG00000020679|UniProtKB=F7DKU1	Serine/threonine-protein phosphatase	ISS	12015605	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00004	Alzheimer disease-presenilin pathway	P00148	Erb-B4 N-terminal fragment	PANTR|Ensembl=ENSPTRG00000012883|UniProtKB=H2QJC5	Receptor protein-tyrosine kinase	ISS	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	ORNAN|Ensembl=ENSOANG00000004797|UniProtKB=F7FFR0	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05912	Dopamine receptor mediated signaling pathway	P05966	EPB41	MOUSE|MGI=MGI=103010|UniProtKB=Q9Z2H5	Band 4.1-like protein 1	ISS	12181426	PubMed	PTHR23280:SF24	BAND 4.1-LIKE PROTEIN 1
P00053	T cell activation	P01312	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	MOUSE|MGI=MGI=102891|UniProtKB=P51829	Adenylate cyclase type 7	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MOUSE|MGI=MGI=97255|UniProtKB=Q02566	Myosin-6	ISS	10938134	PubMed	PTHR13140:SF721	MYOSIN-6
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	MOUSE|MGI=MGI=101863|UniProtKB=P05063	Fructose-bisphosphate aldolase C	ISS	3105602	PubMed	PTHR11627:SF3	FRUCTOSE-BISPHOSPHATE ALDOLASE C
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	PANTR|Ensembl=ENSPTRG00000018351|UniProtKB=H2QTA4	Collagen, type XII, alpha 1	ISS	10778855	PubMed	PTHR45047:SF2	COLLAGEN ALPHA-1 XII  CHAIN
P00018	EGF receptor signaling pathway	P00539	14-3-3	CANAL|CGD=CAL0000198341|UniProtKB=O42766	14-3-3 protein homolog	IGI	21626410	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	TAS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	IGI	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	HUMAN|HGNC=6091|UniProtKB=P06213	Insulin receptor	ISS	14500580	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P00053	T cell activation	P01298	NFkappaB	PANTR|Ensembl=ENSPTRG00000002888|UniProtKB=H2Q2H2	Uncharacterized protein	ISS	12574369	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	PHYIT|EnsemblGenome=PITG_06376|UniProtKB=D0N4Q3	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta, putative	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00057	Wnt signaling pathway	P01455	Smad4	MACMU|Ensembl=ENSMMUG00000000340|UniProtKB=F6YMS3	Mothers against decapentaplegic homolog	ISS	12736218	PubMed	PTHR13703:SF36	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5
P00018	EGF receptor signaling pathway	P00559	MEK1-2	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IGI	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	HUMAN|HGNC=10485|UniProtKB=Q15413	Ryanodine receptor 3	ISS	15858232	PubMed	PTHR13715:SF16	RYANODINE RECEPTOR 3
P00019	Endothelin signaling pathway	P00587	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01142	p90RSK	HUMAN|HGNC=10430|UniProtKB=Q15418	Ribosomal protein S6 kinase alpha-1	ISS	7688567	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00059	p53 pathway	P04633	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=97441|UniProtKB=P42866	Mu-type opioid receptor	IDA	12093103	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00047	PDGF signaling pathway	P01161	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00184	Src	DROME|FlyBase=FBgn0262733|UniProtKB=P00528	Tyrosine-protein kinase Src64B	ISS			PTHR24418:SF283	TYROSINE-PROTEIN KINASE SRC64B
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	RAT|RGD=2746|UniProtKB=P31424	Metabotropic glutamate receptor 5	ISS	92317054	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00047	PDGF signaling pathway	P01171	PLCgamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	XENTR|Xenbase=XB-GENE-483904|UniProtKB=F7ESG8	Receptor protein serine/threonine kinase (Fragment)	ISS	10683140	PubMed	PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P00029	Huntington disease	P00805	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	NAS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00004	Alzheimer disease-presenilin pathway	P00113	Erb-B4 transmembrane fragment	MACMU|Ensembl=ENSMMUG00000001674|UniProtKB=F7G3H1	Receptor protein-tyrosine kinase	ISS	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000039151|UniProtKB=F6R5F6	Uncharacterized protein	ISS	12181435	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00709	Glycogen synthase D	ORNAN|Ensembl=ENSOANG00000004219|UniProtKB=F7BKZ4	Uncharacterized protein	ISS	4212312	PubMed	PTHR10176:SF2	GLYCOGEN  STARCH  SYNTHASE, MUSCLE
P00045	Notch signaling pathway	P01099	Notch	HUMAN|HGNC=7882|UniProtKB=Q04721	Neurogenic locus notch homolog protein 2	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P05914	Nicotine degradation	P05980	UGT2B7	HUMAN|HGNC=12554|UniProtKB=P16662	UDP-glucuronosyltransferase 2B7	IDA	15470160	PubMed	PTHR11926:SF731	UDP-GLUCURONOSYLTRANSFERASE 2B7
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	XENTR|Xenbase=XB-GENE-1002222|UniProtKB=F6YTJ1	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF317	MYOSIN-9
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	IGI	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	CANLF|Ensembl=ENSCAFG00000010873|UniProtKB=E2QUR2	Uncharacterized protein	ISS			PTHR43382:SF2	BIFUNCTIONAL GLUTAMATE/PROLINE--TRNA LIGASE
P00005	Angiogenesis	P00203	Erk	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	P04623	CBP	ARATH|TAIR=AT1G55970|UniProtKB=Q9LG11	Histone acetyltransferase HAC4	IDA	10664585	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MOUSE|MGI=MGI=1339710|UniProtKB=G3UW82	MCG140437, isoform CRA_d	ISS	10938134	PubMed	PTHR13140:SF385	MYOSIN-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00898	FKHR	PANTR|Ensembl=ENSPTRG00000018476|UniProtKB=H2R710	Forkhead box O3	ISS	14775847	gi	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MACMU|Ensembl=ENSMMUG00000007027|UniProtKB=F7F210	Alpha-cardiac actin	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	RCA	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00047	PDGF signaling pathway	P01160	IP3 receptor	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00059	p53 pathway	G04694	p110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	G01531	BDNF	BOVIN|Ensembl=ENSBTAG00000008134|UniProtKB=Q95106	Brain-derived neurotrophic factor	ISS	11408619	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00045	Notch signaling pathway	P01104	Serrate	PANTR|Ensembl=ENSPTRG00000013250|UniProtKB=H2QJZ0	Delta-like protein	ISS	7697721	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00005	Angiogenesis	P00223	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00018	EGF receptor signaling pathway	P00561	STAT	MACMU|Ensembl=ENSMMUG00000010705|UniProtKB=F7G8V4	Signal transducer and activator of transcription	ISS	95236292	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01465	Ggamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00019	Endothelin signaling pathway	P00590	IP3 R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	IGI	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00035	Interferon-gamma signaling pathway	P00959	IFNGR1	MOUSE|MGI=MGI=107654|UniProtKB=Q63953	Ifngr2 protein	IC			PTHR20859:SF46	INTERFERON GAMMA RECEPTOR 2
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000008362|UniProtKB=F7HPU3	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF9	PROTOCADHERIN-18
P00055	Transcription regulation by bZIP transcription factor	P01396	TFIIFbeta	DROME|FlyBase=FBgn0010421|UniProtKB=P41900	General transcription factor IIF subunit 2	ISS			PTHR10445:SF0	GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2
P00036	Interleukin signaling pathway	P00996	STAT	RAT|RGD=1309063|UniProtKB=Q1KQ07	Signal transducer and activator of transcription	ISS	12039028	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00056	VEGF signaling pathway	P01407	Erk	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	HUMAN|HGNC=4584|UniProtKB=Q05586	Glutamate receptor ionotropic, NMDA 1	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00017	DNA replication	P00536	DNA Topisomerase	CAEEL|WormBase=WBGene00006595|UniProtKB=O17966	DNA topoisomerase 1	ISS			PTHR10290:SF3	DNA TOPOISOMERASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00019	Endothelin signaling pathway	P00572	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00056	VEGF signaling pathway	P01412	HSP27	MONDO|Ensembl=ENSMODG00000021030|UniProtKB=F6QYV3	Uncharacterized protein	ISS			PTHR11527:SF36	ALPHA-CRYSTALLIN A CHAIN
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00052	TGF-beta signaling pathway	P01288	FKBP12	XENTR|Ensembl=ENSXETG00000011165|UniProtKB=F6YTY1	Peptidyl-prolyl cis-trans isomerase (Fragment)	ISS			PTHR10516:SF341	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE
P00012	Cadherin signaling pathway	P00474	Wnt	BOVIN|Ensembl=ENSBTAG00000016012|UniProtKB=F1N5R1	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P00036	Interleukin signaling pathway	P00973	PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02736	Coenzyme A biosynthesis	P02885	Pantothenate kinase	DROME|FlyBase=FBgn0011205|UniProtKB=Q9NHN2	Fumble	ISS			PTHR12280:SF30	FUMBLE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000026580|UniProtKB=F1MB93	Uncharacterized protein	ISS	12441358	PubMed	PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IGI	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00048	PI3 kinase pathway	P01202	p85	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	PANTR|Ensembl=ENSPTRG00000006289|UniProtKB=H2Q875	Uncharacterized protein	ISS			PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IGI	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01456	beta-arrestin	RAT|RGD=2156|UniProtKB=P29066	Beta-arrestin-1	IDA	9388255	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00018	EGF receptor signaling pathway	P00558	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04431	5HT transporter	MOUSE|MGI=MGI=96285|UniProtKB=Q60857	Sodium-dependent serotonin transporter	ISS	14653308	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P00036	Interleukin signaling pathway	P00990	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00624	14-3-3	BOVIN|Ensembl=ENSBTAG00000000236|UniProtKB=P63103	14-3-3 protein zeta/delta	ISS	92283271	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04496	Mdm2	HUMAN|HGNC=6974|UniProtKB=O15151	Protein Mdm4	ISS			PTHR13844:SF20	PROTEIN MDM4
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	CAEEL|WormBase=WBGene00008205|UniProtKB=O17680	Probable S-adenosylmethionine synthase 1	ISS			PTHR11964:SF13	S-ADENOSYLMETHIONINE SYNTHASE 1-RELATED
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00053	T cell activation	P01326	CD3 delta	MACMU|Ensembl=ENSMMUG00000017595|UniProtKB=F6WI60	Uncharacterized protein	ISS	9348303	PubMed	PTHR10570:SF5	T-CELL SURFACE GLYCOPROTEIN CD3 DELTA CHAIN
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IGI	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	15531926	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00020	FAS signaling pathway	P00616	Nuclear Lamin	ANOGA|Gene=AgaP_AGAP008015|UniProtKB=Q7PNC2	AGAP008015-PA	ISS			PTHR23239:SF234	LAMIN DM0-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00052	TGF-beta signaling pathway	P01285	TAK	MOUSE|MGI=MGI=2446584|UniProtKB=P58500	MAP3K7 C-terminal-like protein	ISS	10683140	PubMed	PTHR26392:SF77	EXTRACELLULAR TYROSINE-PROTEIN KINASE PKDCC
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00001	Adrenaline and noradrenaline biosynthesis	P00067	MAO	CANLF|Gene=MAOB|UniProtKB=Q7YRB7	Amine oxidase [flavin-containing] B	ISS	8602220	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	MOUSE|MGI=MGI=98728|UniProtKB=Q64729	TGF-beta receptor type-1	TAS	9395284	PubMed	PTHR23255:SF61	TGF-BETA RECEPTOR TYPE-1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00005	Angiogenesis	P00221	JNK1	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00048	PI3 kinase pathway	G01544	GADD45	PANTR|Ensembl=ENSPTRG00000000842|UniProtKB=H2R902	Growth arrest and DNA-damage-inducible, alpha	ISS	9827804	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P00034	Integrin signalling pathway	P00912	Arp2/3	MONDO|Ensembl=ENSMODG00000011628|UniProtKB=F6U132	Actin-related protein 2/3 complex subunit 3	ISS	9359840	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	BOVIN|Ensembl=ENSBTAG00000009702|UniProtKB=F1N775	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF368	MYOSIN-8
P00056	VEGF signaling pathway	P01407	Erk	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00049	Parkinson disease	P01212	p38 MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	NAS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347740|UniProtKB=E9FXV8	Cytoplasmatic actin	ISS	10974003	PubMed	PTHR11937:SF277	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00779	TBP	METAC|EnsemblGenome=MA_4331|UniProtKB=Q8TI26	TATA-box-binding protein 1	IPI	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	MOUSE|MGI=MGI=1339656|UniProtKB=Q61036	Serine/threonine-protein kinase PAK 3	ISS	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IGI	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00034	Integrin signalling pathway	P00941	Integrin alpha	HUMAN|HGNC=6147|UniProtKB=P38570	Integrin alpha-E	IPI	3487386	PubMed	PTHR23220:SF79	INTEGRIN ALPHA-E
P00034	Integrin signalling pathway	P00916	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	ISS	15860573	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P05918	p38 MAPK pathway	P06020	p38delta	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00181	SHP2	MONDO|Ensembl=ENSMODG00000003120|UniProtKB=F6WVD2	Tyrosine-protein phosphatase non-receptor type	ISS	14534538	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00048	PI3 kinase pathway	P01177	P110ACT	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	HUMAN|HGNC=4421|UniProtKB=P30968	Gonadotropin-releasing hormone receptor	ISS			PTHR24241:SF22	GONADOTROPIN-RELEASING HORMONE RECEPTOR
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	IDA	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00019	Endothelin signaling pathway	P00590	IP3 R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00047	PDGF signaling pathway	P01165	SRF	XENTR|Xenbase=XB-GENE-482036|UniProtKB=F7BXX1	Uncharacterized protein (Fragment)	ISS	2009862	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P04393	Ras Pathway	P04558	p38	DROME|FlyBase=FBgn0024846|UniProtKB=O61443	Mitogen-activated protein kinase 14B	ISS	11707292	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	XENTR|Xenbase=XB-GENE-961282|UniProtKB=Q6DF43	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00021	FGF signaling pathway	P00648	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00006	Apoptosis signaling pathway	P00271	Bax	BOVIN|Ensembl=ENSBTAG00000013340|UniProtKB=O02703	Apoptosis regulator BAX	ISS	8358790	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00060	Ubiquitin proteasome pathway	P01491	E2	MACMU|Ensembl=ENSMMUG00000013069|UniProtKB=F7H5G8	Ubiquitin-conjugating enzyme E2 E2	ISS			PTHR24068:SF62	UBIQUITIN-CONJUGATING ENZYME E2 E2
P00012	Cadherin signaling pathway	P00477	GSK3beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	RAT|RGD=61863|UniProtKB=P19493	Glutamate receptor 4	ISS	10331083	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	TAS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	HUMAN|HGNC=9508|UniProtKB=P49768	Presenilin-1	IDA	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00021	FGF signaling pathway	P00628	JNK1-3	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CANLF|Ensembl=ENSCAFG00000004930|UniProtKB=E2RFB5	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00045	Notch signaling pathway	P01120	NIcs	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	1764995	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00053	T cell activation	P01335	jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	DANRE|ZFIN=ZDB-GENE-030616-53|UniProtKB=Q71E60	AMPA receptor subunit GluR3B	ISS	20112749	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	TAS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MACMU|Ensembl=ENSMMUG00000016675|UniProtKB=F6VTB5	Uncharacterized protein	ISS	11554549	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00057	Wnt signaling pathway	P01446	Calcineurin	CANLF|Ensembl=ENSCAFG00000010644|UniProtKB=F2Z4P5	Serine/threonine-protein phosphatase	ISS	12015605	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	MOUSE|MGI=MGI=1351344|UniProtKB=Q68ED2	Metabotropic glutamate receptor 7	ISS	12488551	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	MOUSE|MGI=MGI=88296|UniProtKB=O55017	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	14507926	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MACMU|Ensembl=ENSMMUG00000022808|UniProtKB=F6UWC3	Actin-related protein 2/3 complex subunit 2	ISS	10940259	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DANRE|ZFIN=ZDB-GENE-040426-1489|UniProtKB=Q6PHV0	Syntaxin 3A	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00005	Angiogenesis	P00249	PAK	MOUSE|MGI=MGI=1339975|UniProtKB=O88643	Serine/threonine-protein kinase PAK 1	ISS	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	NEUCR|EnsemblGenome=EFNCRG00000004240|UniProtKB=Q01386	cAMP-dependent protein kinase regulatory subunit	IC	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00009	Axon guidance mediated by netrin	P00366	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00018	EGF receptor signaling pathway	P00559	MEK1-2	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IGI	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02728	Arginine biosynthesis	P02846	Ornithine carbamoyl transferase	SYNY3|EnsemblGenome=BAA10847|UniProtKB=Q55497	Ornithine carbamoyltransferase	ISS			PTHR11405:SF1	ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IDA	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00009	Axon guidance mediated by netrin	P00359	NFAT	MACMU|Ensembl=ENSMMUG00000003370|UniProtKB=F7E8G2	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02770	Pyridoxal phosphate salvage pathway	P03121	Pyridoxal kinase	MACMU|Ensembl=ENSMMUG00000012300|UniProtKB=F7DLS4	Uncharacterized protein	ISS	15082224	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P00047	PDGF signaling pathway	P01152	RasGAP	PANTR|Ensembl=ENSPTRG00000015472|UniProtKB=H2QNH9	Uncharacterized protein	ISS	20475167	gi	PTHR10194:SF21	RAS GTPASE-ACTIVATING PROTEIN 2
P05913	Enkephalin release	P05974	G-Protein (i)	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	IC	8170357	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00036	Interleukin signaling pathway	P00974	Receptor subunit beta	BOVIN|Gene=IL12RB2|UniProtKB=Q9BEG2	Interleukin-12 receptor subunit beta-2	IDA	12036584	PubMed	PTHR23036:SF79	INTERLEUKIN-12 RECEPTOR SUBUNIT BETA-2
P00005	Angiogenesis	P00182	p38MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00645	Rac	ARATH|TAIR=AT3G51300|UniProtKB=P92978	Rac-like GTP-binding protein ARAC11	ISS	12932731	PubMed	PTHR24072:SF179	RAC-LIKE GTP-BINDING PROTEIN ARAC1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P02723	Adenine and hypoxanthine salvage pathway	P02811	Adenosine deaminase	RAT|RGD=2031|UniProtKB=Q920P6	Adenosine deaminase	ISS			PTHR11409:SF43	ADENOSINE DEAMINASE
P00021	FGF signaling pathway	P00645	Rac	ORYSJ|EnsemblGenome=OS02G0120800|UniProtKB=Q6ZHA3	Rac-like GTP-binding protein 6	ISS	12932731	PubMed	PTHR24072:SF261	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00053	T cell activation	P01309	fos	CANLF|Ensembl=ENSCAFG00000017040|UniProtKB=E2QYK5	Uncharacterized protein	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	RAT|RGD=1305515|UniProtKB=F1M0G0	Protein Rgs17	ISS	8756726	PubMed	PTHR10845:SF196	REGULATOR OF G-PROTEIN SIGNALING 17
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00839	SHIP	PANTR|Ensembl=ENSPTRG00000004031|UniProtKB=H2Q4C6	Inositol polyphosphate phosphatase-like 1	ISS	10381377	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00012	Cadherin signaling pathway	P00470	F-actin	ORNAN|Ensembl=ENSOANG00000000460|UniProtKB=F7F4W9	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	HUMAN|HGNC=784|UniProtKB=P15336	Cyclic AMP-dependent transcription factor ATF-2	TAS	15218628	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00021	FGF signaling pathway	P00624	14-3-3	SCHMA|EnsemblGenome=Smp_009760|UniProtKB=G4LUI9	14-3-3 protein, putative	ISS	10407019	PubMed	PTHR18860:SF13	14-3-3 PROTEIN ZETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00005	Angiogenesis	P00243	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00983	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	EMENI|EnsemblGenome=CADANIAG00002670|UniProtKB=Q5BH99	G-protein beta subunit [Source:UniProtKB/TrEMBLAcc:O74214]	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00034	Integrin signalling pathway	P00932	FAK	RAT|RGD=3443|UniProtKB=O35346	Focal adhesion kinase 1	IPI	12640026	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00054	Toll receptor signaling pathway	P01368	MKK2	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00019	Endothelin signaling pathway	P00589	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IGI	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01067	AChE	CHICK|Ensembl=ENSGALG00000009478|UniProtKB=F1NV99	Carboxylic ester hydrolase	IC			PTHR43918:SF5	CHOLINESTERASE
P00029	Huntington disease	P00775	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00053	T cell activation	P01321	SLP-76	CANLF|Ensembl=ENSCAFG00000016961|UniProtKB=E2RRX6	Uncharacterized protein	ISS	9665884	PubMed	PTHR14098:SF1	LYMPHOCYTE CYTOSOLIC PROTEIN 2
P00056	VEGF signaling pathway	P01414	PLC-gamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00018	EGF receptor signaling pathway	P00551	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	IGI	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01299	TCR Beta	BOVIN|Ensembl=ENSBTAG00000047657|UniProtKB=E1BEU5	Uncharacterized protein	IDA			PTHR23268:SF6	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IDA	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00036	Interleukin signaling pathway	P00972	MNK1/2	RAT|RGD=1559603|UniProtKB=Q4G050	MAP kinase-interacting serine/threonine-protein kinase 1	ISS	9155017	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00780	Microtubule	DANRE|ZFIN=ZDB-GENE-030131-7741|UniProtKB=Q6PE34	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF93	SUBFAMILY NOT NAMED
P02763	Peptidoglycan biosynthesis	P03084	UDP-N-acetylmuramoylalanyl-D-glutamate 2,6-diaminopimelate ligase	ARATH|TAIR=AT1G63680|UniProtKB=F4I3P9	Putative UDP-N-acetylmuamoylalanyl-d-glutamate-2,6-diaminopimelate ligase	ISS			PTHR23135:SF4	UDP-N-ACETYLMUAMOYLALANYL-D-GLUTAMATE-2,6-DIAMINOPIMELATE LIGASE-RELATED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IDA	3045562	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00021	FGF signaling pathway	P00644	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00015	Circadian clock system	P00505	Cry	PANTR|Ensembl=ENSPTRG00000005396|UniProtKB=H2Q6S7	Cryptochrome 1 (Photolyase-like)	ISS	10428031	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00029	Huntington disease	P00807	Actin	RAT|RGD=1309504|UniProtKB=D3ZRN3	Protein Actbl2	ISS	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00012	Cadherin signaling pathway	P00477	GSK3beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00019	Endothelin signaling pathway	P00573	signal peptidase	HUMAN|HGNC=17718|UniProtKB=P67812	Signal peptidase complex catalytic subunit SEC11A	ISS	2092035	PubMed	PTHR10806:SF8	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11A-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	20216076	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00005	Angiogenesis	P00181	SHP2	CHICK|Ensembl=ENSGALG00000004821|UniProtKB=Q90687	Tyrosine-protein phosphatase non-receptor type 11	ISS	7681589	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00029	Huntington disease	P00786	ARF	TRIAD|EnsemblGenome=TriadG63238|UniProtKB=B3RQZ1	ADP-ribosylation factor 1	ISS	11752622	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P02749	Leucine biosynthesis	P03000	Branched chain amino acid aminotransferase	YEAST|SGD=S000003909|UniProtKB=P47176	Branched-chain-amino-acid aminotransferase, cytosolic	ISS			PTHR11825:SF44	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00036	Interleukin signaling pathway	P00973	PKB	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00057	Wnt signaling pathway	P01428	Frizzled	MACMU|Ensembl=ENSMMUG00000007486|UniProtKB=F6QL95	Frizzled-3	ISS	11212302	PubMed	PTHR11309:SF22	FRIZZLED-3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00625	MKK3,6	MACMU|Ensembl=ENSMMUG00000010904|UniProtKB=F7GLY5	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	BOVIN|Ensembl=ENSBTAG00000003602|UniProtKB=Q3SZ41	Recombining binding protein suppressor of hairless	ISS	12145413	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P02783	Tryptophan biosynthesis	P03209	Anthranilate phosphoribosyl transferase	SCHPO|PomBase=SPBC1539.09c|UniProtKB=Q92370	Multifunctional tryptophan biosynthesis protein	ISS			PTHR43418:SF4	MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN
P04393	Ras Pathway	P04542	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	TAS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00046	Oxidative stress response	P01135	p38	DROME|FlyBase=FBgn0024846|UniProtKB=O61443	Mitogen-activated protein kinase 14B	TAS	11274345	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00057	Wnt signaling pathway	P01444	Wnt	PANTR|Ensembl=ENSPTRG00000004892|UniProtKB=H2Q5U3	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04393	Ras Pathway	P04542	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06213	DPP signaling pathway	P06278	LACK	DROME|FlyBase=FBgn0029006|UniProtKB=Q9V853	E3 ubiquitin-protein ligase Smurf1	IEA	http://flybase.org/reports/FBgn0029006.html	Website	PTHR11254:SF395	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P00053	T cell activation	P01336	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00025	Hedgehog signaling pathway	P00682	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	ISS	2303451	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P02784	Tyrosine biosynthesis	P03212	Chorismate mutase	RHOBA|EnsemblGenome=RB8741|UniProtKB=Q7UMM1	Chorismate mutase	ISS			PTHR21164:SF0	SUBFAMILY NOT NAMED
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000020887|UniProtKB=F1MP22	Uncharacterized protein	ISS	14507926	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	BOVIN|Ensembl=ENSBTAG00000047202|UniProtKB=G3N3K3	Uncharacterized protein	ISS	11554554	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000025240|UniProtKB=F7A7I3	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00648	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IGI	15572354	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00047	PDGF signaling pathway	P01161	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00983	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=69424|UniProtKB=Q99P84	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	12176394	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P04398	p53 pathway feedback loops 2	P04668	p53	HUMAN|HGNC=11998|UniProtKB=P04637	Cellular tumor antigen p53	TAS	11313951	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00706	RGS-PX1	MOUSE|MGI=MGI=2661416|UniProtKB=Q6PHS6	Sorting nexin-13	ISS	11729322	PubMed	PTHR22775:SF30	SORTING NEXIN-13
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00029	Huntington disease	P00775	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS			PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF31	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00624	14-3-3	BOVIN|Ensembl=ENSBTAG00000000236|UniProtKB=P63103	14-3-3 protein zeta/delta	ISS	12615066	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00371	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	9298898	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00807	Actin	TRIVA|Gene=TVAG_054030|UniProtKB=A2G1K5	Actin	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PHYPA|Gene=PHYPADRAFT_107830|UniProtKB=A9TBG2	Actin 7	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00005	Angiogenesis	P00219	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00059	p53 pathway	G01572	NOXA	MACMU|Ensembl=ENSMMUG00000006392|UniProtKB=F7GWT5	Uncharacterized protein	ISS			PTHR43735:SF9	APOPTOSIS-INDUCING FACTOR 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	DROME|FlyBase=FBgn0001961|UniProtKB=O97182	Actin related complex p41 subunit	ISS	12473693	PubMed	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Gene=HTR1E|UniProtKB=Q9N2B6	5-hydroxytryptamine receptor 1E (Fragment)	ISS	1608964	PubMed	PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00646	RasGAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	IPI	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	MONDO|Ensembl=ENSMODG00000020981|UniProtKB=F6S570	Uncharacterized protein	ISS	12374786	PubMed	PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P00034	Integrin signalling pathway	P00936	PI3K	ARATH|TAIR=AT1G60490|UniProtKB=P42339	Phosphatidylinositol 3-kinase VPS34	IPI	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00005	Angiogenesis	P00211	GSK3beta	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	RCA	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01130	CHOP	PANTR|Ensembl=ENSPTRG00000022781|UniProtKB=H2R2A8	DNA damage-inducible transcript 3 protein	ISS	10207617	PubMed	PTHR16833:SF0	DNA DAMAGE-INDUCIBLE TRANSCRIPT 3 PROTEIN
P00038	JAK/STAT signaling pathway	P01027	STAT	BOVIN|Gene=STAT5A|UniProtKB=Q95115	Signal transducer and activator of transcription 5A	ISS	95188889	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00018	EGF receptor signaling pathway	P00542	EGFR	RAT|RGD=2543|UniProtKB=G3V6K6	Receptor protein-tyrosine kinase	IGI	90258888	PubMed	PTHR24416:SF91	EPIDERMAL GROWTH FACTOR RECEPTOR
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01230	Src kinase	PANTR|Ensembl=ENSPTRG00000007282|UniProtKB=H2Q9T1	Tyrosine-protein kinase	ISS	7687537	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00034	Integrin signalling pathway	P00922	Collagen	RAT|RGD=70921|UniProtKB=F1LQ00	Protein Col5a2	ISS	10778855	PubMed	PTHR24023:SF539	COLLAGEN ALPHA-2 V  CHAIN
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00015	Circadian clock system	P00504	Per	RAT|RGD=61945|UniProtKB=Q9Z301	Period circadian protein homolog 2	ISS			PTHR11269:SF9	PERIOD CIRCADIAN PROTEIN HOMOLOG 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00807	Actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	ISS	11889139	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00052	TGF-beta signaling pathway	P01276	Co-Smads	XENTR|Xenbase=XB-GENE-485691|UniProtKB=F7BDU6	Mothers against decapentaplegic homolog (Fragment)	ISS	10693808	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P00021	FGF signaling pathway	P00648	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IGI	10747026	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05966	EPB41	PANTR|Ensembl=ENSPTRG00000009844|UniProtKB=H2QE82	Uncharacterized protein	ISS	12181426	PubMed	PTHR23280:SF20	BAND 4.1-LIKE PROTEIN 3
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00034	Integrin signalling pathway	P00924	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MACMU|Ensembl=ENSMMUG00000015717|UniProtKB=F6SFA9	Serotonin receptor type 1B	ISS	12441358	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05915	Opioid proenkephalin pathway	P05994	G-protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	IDA	12191995	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	8649368	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	MYCTU|EnsemblGenome=LH57_15610|UniProtKB=I6X5K1	Glutamine synthetase	ISS			PTHR43785:SF5	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00627	ERK1-2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	IDA	9836510	gi	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	IC	9199552	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04398	p53 pathway feedback loops 2	P04668	p53	BOVIN|Ensembl=ENSBTAG00000005812|UniProtKB=G3X6J7	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00012	Cadherin signaling pathway	P00475	Frizzled	PANTR|Ensembl=ENSPTRG00000028511|UniProtKB=H2R570	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF81	FRIZZLED-1
P02755	Methylmalonyl pathway	P03034	Methylmalonyl-CoA mutase	DEIRA|EnsemblGenome=DR_1084|UniProtKB=Q9RVE5	Methylmalonyl-CoA mutase	ISS			PTHR42710:SF1	METHYLMALONYL-COA MUTASE, MITOCHONDRIAL
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00020	FAS signaling pathway	P00608	Pro-Caspase3	HUMAN|HGNC=1504|UniProtKB=P42574	Caspase-3	IGI	11675509	PubMed	PTHR10454:SF198	CASPASE-3
P00019	Endothelin signaling pathway	P00587	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	PHYPA|Gene=PHYPADRAFT_170715|UniProtKB=A9TLC7	Rop-family small GTPase	ISS	12932731	PubMed	PTHR24072:SF194	RAC-LIKE GTP-BINDING PROTEIN ARAC4-RELATED
P00034	Integrin signalling pathway	P00932	FAK	HUMAN|HGNC=9612|UniProtKB=Q14289	Protein-tyrosine kinase 2-beta	IPI	10753828	PubMed	PTHR24418:SF94	PROTEIN-TYROSINE KINASE 2-BETA
P00056	VEGF signaling pathway	P01423	p38MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00006	Apoptosis signaling pathway	P00306	TRAF2	CANLF|Ensembl=ENSCAFG00000019541|UniProtKB=J9NS71	Uncharacterized protein	ISS	8069916	PubMed	PTHR10131:SF21	TNF RECEPTOR-ASSOCIATED FACTOR 2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ORYSJ|EnsemblGenome=OS11G0163100|UniProtKB=Q67G20	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00009	Axon guidance mediated by netrin	P00366	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CAEBR|Gene=CBG21212|UniProtKB=A8XZL0	Protein CBG21212	ISS			PTHR13140:SF302	MYOSIN HEAVY CHAIN STRUCTURAL GENES
P00054	Toll receptor signaling pathway	P01355	AP1	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00019	Endothelin signaling pathway	P00585	ECE1-3	CANLF|Ensembl=ENSCAFG00000011211|UniProtKB=E2QY56	Uncharacterized protein	ISS	9931490	PubMed	PTHR11733:SF195	ENDOTHELIN-CONVERTING ENZYME-LIKE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00054	Toll receptor signaling pathway	P01375	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00049	Parkinson disease	P01212	p38 MAPK	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00046	Oxidative stress response	P01135	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00049	Parkinson disease	P01211	ERK	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	IDA	9836510	gi	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CANLF|Ensembl=ENSCAFG00000016020|UniProtKB=O18840	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00012	Cadherin signaling pathway	P00474	Wnt	PANTR|Ensembl=ENSPTRG00000019627|UniProtKB=H2QVA4	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Ensembl=ENSGALG00000009621|UniProtKB=P60706	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00059	p53 pathway	G04694	p110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00060	Ubiquitin proteasome pathway	P01490	E3	YEAST|SGD=S000003109|UniProtKB=P53119	Probable E3 ubiquitin-protein ligase HUL5	ISS			PTHR11254:SF357	UBIQUITIN-PROTEIN LIGASE E3C
P06664	Gonadotropin-releasing hormone receptor pathway	P06831	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	RCA	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00059	p53 pathway	G04694	p110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00797	p53	BOVIN|Ensembl=ENSBTAG00000001069|UniProtKB=P67939	Cellular tumor antigen p53	TAS	14744434	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	3755548	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P02763	Peptidoglycan biosynthesis	P03092	Phospho-N-acetylmuramoyl pentapeptide transferase	BACSU|EnsemblGenome=BSU15190|UniProtKB=Q03521	Phospho-N-acetylmuramoyl-pentapeptide-transferase	ISS			PTHR22926:SF5	PHOSPHO-N-ACETYLMURAMOYL-PENTAPEPTIDE-TRANSFERASE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	TRYB2|Gene=Tb11.v4.0004|UniProtKB=Q382Q3	Ribonucleoside-diphosphate reductase small chain	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00018	EGF receptor signaling pathway	P00560	Raf-1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00008	Axon guidance mediated by Slit/Robo	P00351	Cxcr4	DANRE|ZFIN=ZDB-GENE-020102-1|UniProtKB=F1QCB2	Uncharacterized protein	ISS	4503175	gi	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	PANTR|Ensembl=ENSPTRG00000009085|UniProtKB=H2RDQ2	Uncharacterized protein	ISS	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IDA	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00010	B cell activation	P00391	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04372	5-Hydroxytryptamine degredation	P04401	Monoamine Oxidase	PANTR|Ensembl=ENSPTRG00000021817|UniProtKB=H2QYH6	Amine oxidase [flavin-containing]	ISS	8602220	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P00021	FGF signaling pathway	P00646	RasGAP	HUMAN|HGNC=35202|UniProtKB=C9J798	Ras GTPase-activating protein 4B	ISS	6635197	gi	PTHR10194:SF4	RAS GTPASE-ACTIVATING PROTEIN 4-RELATED
P06664	Gonadotropin-releasing hormone receptor pathway	P06753	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	RCA	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P00018	EGF receptor signaling pathway	P00554	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	8264585	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00001	Adrenaline and noradrenaline biosynthesis	P00067	MAO	HUMAN|HGNC=6833|UniProtKB=P21397	Amine oxidase [flavin-containing] A	ISS	8602220	PubMed	PTHR43563:SF3	AMINE OXIDASE  FLAVIN-CONTAINING  A
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00754	PDEgamma	ORNAN|Ensembl=ENSOANG00000002699|UniProtKB=F6ZK66	Uncharacterized protein	ISS	3011376	PubMed	PTHR12122:SF4	RETINAL ROD RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT GAMMA
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	PANTR|Ensembl=ENSPTRG00000002775|UniProtKB=H2RB55	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00006	Apoptosis signaling pathway	P00303	c-Jun	XENTR|Xenbase=XB-GENE-482228|UniProtKB=F6RYL1	Uncharacterized protein	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00047	PDGF signaling pathway	P01153	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	IC	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04393	Ras Pathway	P04558	p38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	IDA	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ORYSJ|EnsemblGenome=OS02G0205300|UniProtKB=Q7GCH3	26S proteasome regulatory particle triple-A ATPase subunit6	ISS			PTHR23073:SF12	26S PROTEASE REGULATORY SUBUNIT 8
P00057	Wnt signaling pathway	P01443	Phospholipase C	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	ANOGA|Gene=AgaP_AGAP011382|UniProtKB=Q7Q2X0	AGAP011382-PA (Fragment)	TAS	11212302	PubMed	PTHR11309:SF47	FRIZZLED
P00046	Oxidative stress response	P01132	c-jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	11840290	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00034	Integrin signalling pathway	P00940	Src	MOUSE|MGI=MGI=103265|UniProtKB=Q922K9	Tyrosine-protein kinase FRK	IPI	11078745	PubMed	PTHR24418:SF296	TYROSINE-PROTEIN KINASE FRK
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g245773|UniProtKB=A7SJX9	Predicted protein	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04393	Ras Pathway	P04558	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	CHICK|Ensembl=ENSGALG00000007039|UniProtKB=F1NG99	Tyrosine-protein kinase receptor	ISS	11182407	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IDA	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00047	PDGF signaling pathway	P01153	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00036	Interleukin signaling pathway	P00973	PKB	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00010	B cell activation	P00391	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01211	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00047	PDGF signaling pathway	P01173	STAT	MONDO|Ensembl=ENSMODG00000028212|UniProtKB=F7BYN4	Signal transducer and activator of transcription	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P05913	Enkephalin release	P05974	G-Protein (i)	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00054	Toll receptor signaling pathway	P01370	TAK1	BOVIN|Ensembl=ENSBTAG00000002625|UniProtKB=A2VDU3	Mitogen-activated protein kinase kinase kinase 7	ISS	10683140	PubMed	PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P06664	Gonadotropin-releasing hormone receptor pathway	P06807	gnai	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04393	Ras Pathway	P04559	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00053	T cell activation	P01315	Calcineurin	CHICK|Ensembl=ENSGALG00000005243|UniProtKB=E1C2T7	Serine/threonine-protein phosphatase	ISS	7532676	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	YEAST|SGD=S000001855|UniProtKB=P60010	Actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05915	Opioid proenkephalin pathway	P05985	Mu or Delta receptor	MONDO|Ensembl=ENSMODG00000008382|UniProtKB=F7CDR6	Uncharacterized protein (Fragment)	ISS	11259498	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	TAS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	CAEBR|Gene=CBG18000|UniProtKB=A8XSS7	Protein CBR-ACY-1	ISS	2491850	PubMed	PTHR11920:SF319	ADENYLATE CYCLASE TYPE 9
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	TAS	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00965	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01179	PKB	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_188187|UniProtKB=E9GJ31	Guanine nucleotide binding protein, q polypeptide	ISS	14765990	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MACMU|Ensembl=ENSMMUG00000016675|UniProtKB=F6VTB5	Uncharacterized protein	ISS	14698601	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	MOUSE|MGI=MGI=88396|UniProtKB=P12657	Muscarinic acetylcholine receptor M1	ISS	11166329	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00053	T cell activation	P01322	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00898	FKHR	BOVIN|Ensembl=ENSBTAG00000011234|UniProtKB=F1N4K5	Uncharacterized protein	ISS	12048180	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	7925653	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Gene=PCDHB2|UniProtKB=Q5DRD2	Protocadherin beta-2	ISS	8120095	PubMed	PTHR24028:SF77	PROTOCADHERIN BETA-2
P00018	EGF receptor signaling pathway	P00565	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01159	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00057	Wnt signaling pathway	P01444	Wnt	MONDO|Ensembl=ENSMODG00000001196|UniProtKB=F7GH85	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00048	PI3 kinase pathway	P01179	PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02775	Salvage pyrimidine ribonucleotides	P03150	Uridine kinase	MONDO|Ensembl=ENSMODG00000001349|UniProtKB=F7FW97	Uridine-cytidine kinase	ISS			PTHR10285:SF70	URIDINE-CYTIDINE KINASE 2
P00029	Huntington disease	P00788	Calpain	RAT|RGD=2269|UniProtKB=P16259	Calpain-3	IDA	11675509	PubMed	PTHR10183:SF329	CALPAIN-3
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	CRYNJ|EnsemblGenome=CND03830|UniProtKB=Q5KI86	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	BOVIN|Ensembl=ENSBTAG00000014674|UniProtKB=P41985	Muscarinic acetylcholine receptor M2	ISS	8100450	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00045	Notch signaling pathway	P01104	Serrate	MACMU|Ensembl=ENSMMUG00000018116|UniProtKB=F7FGM9	Delta-like protein	ISS	7697721	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	RAT|RGD=1359485|UniProtKB=Q5U302	Catenin (Cadherin associated protein), alpha 1	ISS	1904011	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000024633|UniProtKB=F1MBU9	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00048	PI3 kinase pathway	P01202	p85	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	IC	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00045	Notch signaling pathway	P01119	NIct	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	1764995	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	TAS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00006	Apoptosis signaling pathway	P00287	TNFR2	PANTR|Ensembl=ENSPTRG00000000164|UniProtKB=H2PY20	Uncharacterized protein	ISS	11907583	PubMed	PTHR23097:SF120	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1B
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P05730	Endogenous cannabinoid signaling	P05746	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P06212	DPP-SCW signaling pathway	P06262	PDP	DROME|FlyBase=FBgn0029958|UniProtKB=Q9W3Q1	GM14286p	IDA	16510868	PubMed	PTHR13832:SF503	PYRUVATE DEHYDROGENASE  ACETYL-TRANSFERRING  -PHOSPHATASE 1, MITOCHONDRIAL
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	RAT|RGD=3370|UniProtKB=Q99ND3	Peroxisome proliferator activated receptor delta, isoform CRA_b	IEP	12356903	PubMed	PTHR24082:SF15	PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DELTA
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	ARATH|TAIR=AT3G53180|UniProtKB=F4J9A0	Nodulin/glutamine synthase-like protein	ISS			PTHR43785:SF2	TYPE-1 GLUTAMINE SYNTHETASE 1
P02770	Pyridoxal phosphate salvage pathway	P03120	Pyridoxamine-5-phosphate oxidase	BOVIN|Ensembl=ENSBTAG00000012259|UniProtKB=Q5E9K3	Pyridoxine-5'-phosphate oxidase	ISS	9601034	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00036	Interleukin signaling pathway	P00965	ERK	HUMAN|HGNC=6880|UniProtKB=Q13164	Mitogen-activated protein kinase 7	IC	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01063	CAT	MOUSE|MGI=MGI=88392|UniProtKB=Q03059	Choline O-acetyltransferase	IC	92155737	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P00047	PDGF signaling pathway	P01143	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05918	p38 MAPK pathway	P06025	SRF	CANLF|Ensembl=ENSCAFG00000001829|UniProtKB=F1PH12	Uncharacterized protein	ISS	15326221	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	89107990	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05917	Opioid proopiomelanocortin pathway	P06010	proopiomelanocortin	MACMU|Ensembl=ENSMMUG00000016463|UniProtKB=F7GBI0	Uncharacterized protein	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00036	Interleukin signaling pathway	P00976	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	P00559	MEK1-2	SCHPO|PomBase=SPBC543.07|UniProtKB=Q9Y884	MAP kinase kinase skh1/pek1	ISS			PTHR24361:SF351	MAP KINASE KINASE MKK1/SSP32-RELATED
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	BOVIN|Ensembl=ENSBTAG00000002522|UniProtKB=A4IFJ2	SYT5 protein	ISS			PTHR10024:SF282	SYNAPTOTAGMIN-5
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	CHICK|Ensembl=ENSGALG00000009405|UniProtKB=F1NKF1	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00019	Endothelin signaling pathway	P00566	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04556	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	IDA	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02778	Sulfate assimilation	P03167	Sulfate adenylyltransferase	EMENI|EnsemblGenome=CADANIAG00005656|UniProtKB=Q12555	Sulfate adenylyltransferase	ISS			PTHR42700:SF1	SULFATE ADENYLYLTRANSFERASE
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=264|UniProtKB=P29275	Adenosine receptor A2b	IDA			PTHR24246:SF18	ADENOSINE RECEPTOR A2B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	RAT|RGD=1308152|UniProtKB=Q5FVM5	Cyclic AMP-responsive element-binding protein 3-like protein 3	RCA			PTHR22952:SF98	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 3
P00037	Ionotropic glutamate receptor pathway	P01026	KA	BOVIN|Ensembl=ENSBTAG00000033153|UniProtKB=F1MG21	Uncharacterized protein	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00029	Huntington disease	G01533	Bax	MACMU|Ensembl=ENSMMUG00000003907|UniProtKB=F6ZV96	Apoptosis regulator BAX isoform alpha	ISS	14963330	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P00021	FGF signaling pathway	P00629	PP2A	MACMU|Ensembl=ENSMMUG00000013047|UniProtKB=F7H808	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04396	Vitamin D metabolism and pathway	P04607	FDX	HUMAN|HGNC=3638|UniProtKB=P10109	Adrenodoxin, mitochondrial	IDA	2969697	PubMed	PTHR23426:SF26	ADRENODOXIN, MITOCHONDRIAL
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	SCHPO|PomBase=SPAC23C4.12|UniProtKB=P40236	Casein kinase I homolog hhp2	IDA	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00048	PI3 kinase pathway	P01187	IR	HUMAN|HGNC=6091|UniProtKB=P06213	Insulin receptor	ISS	11182407	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00019	Endothelin signaling pathway	P00587	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00111	C99	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04392	P53 pathway feedback loops 1	G04685	p73DeltaN	ORNAN|Ensembl=ENSOANG00000013795|UniProtKB=F7DUR2	Uncharacterized protein (Fragment)	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00054	Toll receptor signaling pathway	P01375	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05918	p38 MAPK pathway	P06022	eEF2K	CANLF|Ensembl=ENSCAFG00000017716|UniProtKB=E2RIJ6	Uncharacterized protein	ISS	11500363	PubMed	PTHR14187:SF56	EUKARYOTIC ELONGATION FACTOR 2 KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00034	Integrin signalling pathway	P00951	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04564	MAPKAP	DROME|FlyBase=FBgn0013987|UniProtKB=P49071	MAP kinase-activated protein kinase 2	ISS			PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P00036	Interleukin signaling pathway	P00982	p27KIP1	CANLF|Gene=CDKN1B|UniProtKB=Q6SLL5	Cyclin-dependent kinase inhibitor 1B	ISS	12244303	PubMed	PTHR10265:SF9	CYCLIN-DEPENDENT KINASE INHIBITOR 1B
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	IC	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	CAEEL|WormBase=WBGene00000203|UniProtKB=Q9XWV3	Probable actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00029	Huntington disease	P00777	CBP	BOVIN|Ensembl=ENSBTAG00000016198|UniProtKB=E1B8D6	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P02766	Phenylethylamine degradation	P03103	Phenylethylamine oxidase	HUMAN|HGNC=549|UniProtKB=O75106	Retina-specific copper amine oxidase	ISS			PTHR10638:SF4	RETINA-SPECIFIC COPPER AMINE OXIDASE
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	MOUSE|MGI=MGI=1338946|UniProtKB=Q61288	Serine/threonine-protein kinase receptor R3	TAS	9395284	PubMed	PTHR23255:SF66	SERINE/THREONINE-PROTEIN KINASE RECEPTOR R3
P00036	Interleukin signaling pathway	P00986	eNOS	MACMU|Ensembl=ENSMMUG00000020437|UniProtKB=F6WEB2	Nitric oxide synthase	ISS	10435050	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00639	Shc	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	ISS	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	XENTR|Xenbase=XB-GENE-977853|UniProtKB=F7EBE7	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00049	Parkinson disease	P01208	Hsp70	YEAST|SGD=S000003947|UniProtKB=P10592	Heat shock protein SSA2	IDA	12150907	PubMed	PTHR19375:SF309	HEAT SHOCK PROTEIN SSA1-RELATED
P05731	GABA-B receptor II signaling	P05752	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	RCA	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00877	MLCK	MOUSE|MGI=MGI=2139434|UniProtKB=Q8VCR8	Myosin light chain kinase 2, skeletal/cardiac muscle	ISS	600922	OMIM	PTHR45210:SF1	MYOSIN LIGHT CHAIN KINASE 2, SKELETAL/CARDIAC MUSCLE
P00004	Alzheimer disease-presenilin pathway	P00118	E-cadherin	RAT|RGD=621089|UniProtKB=F1LMI3	Cadherin 3, type 1, P-cadherin (Placental)	ISS	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MOUSE|MGI=MGI=2152453|UniProtKB=Q2NL51	Glycogen synthase kinase-3 alpha	ISS	21361340	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	BOVIN|Ensembl=ENSBTAG00000006189|UniProtKB=P63258	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	DROME|FlyBase=FBgn0260964|UniProtKB=Q8IH57	GH10249p	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00004	Alzheimer disease-presenilin pathway	P00114	actin	TRIAD|EnsemblGenome=TriadG63375|UniProtKB=B3S5E4	Non-muscle actin 6.2	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	P01437	TCF	MOUSE|MGI=MGI=1202876|UniProtKB=Q9Z1J1	Transcription factor 7-like 1	IDA	9118222	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=5289|UniProtKB=P28221	5-hydroxytryptamine receptor 1D	IDA	12181435	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P04393	Ras Pathway	P04553	PAK	PANTR|Ensembl=ENSPTRG00000015787|UniProtKB=H2QP14	Uncharacterized protein	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00049	Parkinson disease	P01235	Fyn kinase	PANTR|Ensembl=ENSPTRG00000018511|UniProtKB=H2QTK7	Tyrosine-protein kinase	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00050	Plasminogen activating cascade	P01250	MMP-13	XENTR|Xenbase=XB-GENE-481559|UniProtKB=F6SRT1	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF165	COLLAGENASE 3
P00029	Huntington disease	P00795	BDNF	DANRE|ZFIN=ZDB-GENE-000412-1|UniProtKB=Q6NZ01	Bdnf protein	TAS	11408619	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00007	Axon guidance mediated by semaphorins	P00340	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04393	Ras Pathway	P04552	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P02752	Mannose metabolism	P03019	P-Mannose mutase	MACMU|Ensembl=ENSMMUG00000022714|UniProtKB=F7GKX1	Phosphomannomutase	ISS	11891694	PubMed	PTHR10466:SF2	PHOSPHOMANNOMUTASE 2
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00049	Parkinson disease	P01234	GRK	CHICK|Ensembl=ENSGALG00000005518|UniProtKB=F1NTL1	Protein-serine/threonine kinase	ISS	10852916	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000008719|UniProtKB=F1MZX0	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00056	VEGF signaling pathway	P01423	p38MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	DANRE|ZFIN=ZDB-GENE-980526-110|UniProtKB=O73727	Insulin	ISS			PTHR11454:SF9	INSULIN-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4404|UniProtKB=P59768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=88399|UniProtKB=P32211	Muscarinic acetylcholine receptor M4	IDA	91373358	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P05913	Enkephalin release	P05972	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	10218114	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00025	Hedgehog signaling pathway	P00682	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00292	IkappaB	MACMU|Ensembl=ENSMMUG00000020374|UniProtKB=F6UMS2	NF-kappa-B inhibitor alpha	ISS	14665694	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00025	Hedgehog signaling pathway	P00692	GSK3	CAEBR|Gene=CBG07560|UniProtKB=A8X4K1	Protein CBG07560	ISS			PTHR24057:SF20	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	IDA	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P02742	Tetrahydrofolate biosynthesis	P02945	Dihydropteroate synthase	RHOBA|EnsemblGenome=RB6484|UniProtKB=Q7UQ75	Dihydropteroate synthase	ISS			PTHR20941:SF1	FOLIC ACID SYNTHESIS PROTEIN FOL1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01438	PP2A	XENTR|Xenbase=XB-GENE-957248|UniProtKB=Q6GLE6	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00011	Blood coagulation	P00409	PAI-2	MACMU|Ensembl=ENSMMUG00000016617|UniProtKB=F6TWU5	Uncharacterized protein	ISS	11929770	PubMed	PTHR11461:SF61	PLASMINOGEN ACTIVATOR INHIBITOR 2
P00030	Hypoxia response via HIF activation	P00819	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04546	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	IDA	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00010	B cell activation	P00385	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12960248	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DROME|FlyBase=FBgn0000047|UniProtKB=P83967	Actin, indirect flight muscle	ISS	11889126	PubMed	PTHR11937:SF368	ACTIN, INDIRECT FLIGHT MUSCLE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00029	Huntington disease	P00799	JNK-2	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P06959	CCKR signaling map	P07235	HDAC7	HUMAN|HGNC=14067|UniProtKB=Q8WUI4	Histone deacetylase 7	RCA	17962809	PubMed	PTHR10625:SF58	HISTONE DEACETYLASE 7
P04398	p53 pathway feedback loops 2	P04665	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05730	Endogenous cannabinoid signaling	P05748	mGluR	CHICK|Ensembl=ENSGALG00000017238|UniProtKB=F1NWG3	Uncharacterized protein	ISS	92317054	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00054	Toll receptor signaling pathway	P01354	NFkappaB	PANTR|Ensembl=ENSPTRG00000002888|UniProtKB=H2Q2H2	Uncharacterized protein	ISS	9133421	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00049	Parkinson disease	G01547	DAT	MOUSE|MGI=MGI=94862|UniProtKB=Q61327	Sodium-dependent dopamine transporter	IDA	15135042	PubMed	PTHR11616:SF38	SODIUM-DEPENDENT DOPAMINE TRANSPORTER
P00021	FGF signaling pathway	P00623	FGF	MOUSE|MGI=MGI=109178|UniProtKB=P70377	Fibroblast growth factor 13	IEP	97376484	PubMed	PTHR11486:SF77	FIBROBLAST GROWTH FACTOR 13
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00022	General transcription by RNA polymerase I	P00652	RNA Polymerase I  Complex	XENTR|Xenbase=XB-GENE-854169|UniProtKB=Q28CR4	Polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa	ISS	12634356	PubMed	PTHR12056:SF2	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC4
P02748	Isoleucine biosynthesis	P02997	Acetolactate synthase	CAEEL|WormBase=WBGene00020831|UniProtKB=O61856	Acetolactate synthase-like protein	ISS			PTHR18968:SF155	ACETOLACTATE SYNTHASE-LIKE PROTEIN
P04395	Vasopressin synthesis	P04596	Endo Peptidase	ARATH|TAIR=AT1G69020|UniProtKB=F4I0I5	Prolyl oligopeptidase-like protein	IC			PTHR11757:SF12	PROLYL ENDOPEPTIDASE-LIKE
P00035	Interferon-gamma signaling pathway	P00953	Jak1	RAT|RGD=69056|UniProtKB=G3V9W2	Tyrosine-protein kinase	ISS	9637709	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00059	p53 pathway	P01482	ARF	PANTR|Ensembl=ENSPTRG00000020827|UniProtKB=H2QX30	Uncharacterized protein	ISS	12082609	PubMed	PTHR24148:SF47	CYCLIN-DEPENDENT KINASE 4 INHIBITOR B-RELATED
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00005	Angiogenesis	P00220	c-Jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	TAKRU|Ensembl=ENSTRUG00000011297|UniProtKB=H2TV18	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00059	p53 pathway	P04631	P21	RAT|RGD=69328|UniProtKB=Q64315	Cyclin-dependent kinase inhibitor 1A	IGI	7774811	PubMed	PTHR10265:SF16	CYCLIN-DEPENDENT KINASE INHIBITOR 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	RAT|RGD=2733|UniProtKB=P42260	Glutamate receptor ionotropic, kainate 2	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00057	Wnt signaling pathway	P01448	CBP	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00021	FGF signaling pathway	P00641	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00047	PDGF signaling pathway	P01160	IP3 receptor	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00034	Integrin signalling pathway	P00931	Integrin beta	CANLF|Ensembl=ENSCAFG00000013735|UniProtKB=F1PPG5	Integrin beta	IDA	386150	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	CHICK|Ensembl=ENSGALG00000001476|UniProtKB=F1NSA8	Uncharacterized protein	ISS	8576107	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00010	B cell activation	P00398	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00015	Circadian clock system	G01503	per	PANTR|Ensembl=ENSPTRG00000008726|UniProtKB=H2QC70	Uncharacterized protein	ISS	20570170	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P00046	Oxidative stress response	P01135	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00194	Paxillin	MOUSE|MGI=MGI=108295|UniProtKB=Q8VI36	Paxillin	IDA	9182576	PubMed	PTHR24216:SF11	PAXILLIN
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01443	Phospholipase C	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IDA	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=17175|UniProtKB=Q9P212	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	15611108	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	BACSU|EnsemblGenome=BSU17460|UniProtKB=P12425	Glutamine synthetase	ISS			PTHR43785:SF1	TYPE-1 GLUTAMINE SYNTHETASE 2
P00001	Adrenaline and noradrenaline biosynthesis	P00071	VAT1	RAT|RGD=3693|UniProtKB=Q01818	Chromaffin granule amine transporter	ISS	11443533	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	DANRE|ZFIN=ZDB-GENE-991119-4|UniProtKB=Q9W6T7	Presenilin-1	IDA	12101103	PubMed	PTHR10202:SF18	PRESENILIN-1
P00046	Oxidative stress response	P01124	Myc	BOVIN|Ensembl=ENSBTAG00000008409|UniProtKB=Q2HJ27	Myc proto-oncogene protein	ISS	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00057	Wnt signaling pathway	P01465	Ggamma	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00005	Angiogenesis	P00189	Fzd	PANTR|Ensembl=ENSPTRG00000028511|UniProtKB=H2R570	Uncharacterized protein	ISS	12549854	PubMed	PTHR11309:SF81	FRIZZLED-1
P00046	Oxidative stress response	P01135	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MACMU|Gene=CXCR2|UniProtKB=Q28519	C-X-C chemokine receptor type 2 (Fragment)	ISS	10741397	PubMed	PTHR10489:SF689	C-X-C CHEMOKINE RECEPTOR TYPE 2
P06959	CCKR signaling map	P07131	CCK-GRR	HUMAN|HGNC=1569|UniProtKB=P06307	Cholecystokinin	RCA	12479974	PubMed	PTHR10786:SF0	CHOLECYSTOKININ
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00048	PI3 kinase pathway	P01194	S6K	BOVIN|Ensembl=ENSBTAG00000009175|UniProtKB=E1BLQ5	Uncharacterized protein	ISS	6755374	gi	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P04398	p53 pathway feedback loops 2	P04657	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	HUMAN|HGNC=1612|UniProtKB=O00421	C-C chemokine receptor-like 2	IC			PTHR10489:SF655	C-C CHEMOKINE RECEPTOR-LIKE 2
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04395	Vasopressin synthesis	P04597	Signal Peptide	TAKRU|Ensembl=ENSTRUG00000015413|UniProtKB=H2UR30	Uncharacterized protein	ISS	1706187	PubMed	PTHR11681:SF13	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	MOUSE|MGI=MGI=109323|UniProtKB=Q02152	5-hydroxytryptamine receptor 2B	ISS	12441358	PubMed	PTHR24247:SF31	5-HYDROXYTRYPTAMINE RECEPTOR 2B
P00005	Angiogenesis	P00220	c-Jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	8837781	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04393	Ras Pathway	P04546	GSK3	RAT|RGD=620351|UniProtKB=P18265	Glycogen synthase kinase-3 alpha	IDA	183955	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00010	B cell activation	P00373	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00558	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00012	Cadherin signaling pathway	P00470	F-actin	ENTHI|EnsemblGenome=EHI_107290|UniProtKB=B1N2P0	Actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	XENTR|Xenbase=XB-GENE-484248|UniProtKB=F7BH92	Serine/threonine-protein kinase receptor (Fragment)	ISS	11252892	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00811	Arp2/3 complex	BOVIN|Gene=ARPC5|UniProtKB=Q3SYX9	Actin-related protein 2/3 complex subunit 5	ISS	10322212	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P05912	Dopamine receptor mediated signaling pathway	P05957	K+ channel	MOUSE|MGI=MGI=3521816|UniProtKB=Q3LS21	Potassium channel subfamily K member 9	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00219	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IDA	15572354	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	PANTR|Ensembl=ENSPTRG00000012911|UniProtKB=H2QJE2	Uncharacterized protein	ISS	10940259	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00896	Insulin IGF	PANTR|Ensembl=ENSPTRG00000024078|UniProtKB=H2R3T0	Insulin-like growth factor 1 (Somatomedin C)	ISS			PTHR11454:SF4	INSULIN-LIKE GROWTH FACTOR I
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04392	P53 pathway feedback loops 1	G04682	MDM-2	RAT|RGD=1309306|UniProtKB=Q5XIN1	Protein Mdm4	ISS			PTHR13844:SF20	PROTEIN MDM4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	TAS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00001	Adrenaline and noradrenaline biosynthesis	P00071	VAT1	MOUSE|MGI=MGI=106684|UniProtKB=Q8R090	Chromaffin granule amine transporter	ISS	11443533	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00005	Angiogenesis	P00239	Eph	BOVIN|Ensembl=ENSBTAG00000016991|UniProtKB=F1N0M5	Uncharacterized protein	ISS	9990854	PubMed	PTHR11304:SF18	EPHRIN-B2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P02738	De novo purine biosynthesis	P02899	GMP synthase	RAT|RGD=1310063|UniProtKB=Q4V7C6	GMP synthase [glutamine-hydrolyzing]	ISS			PTHR11922:SF2	GMP SYNTHASE  GLUTAMINE-HYDROLYZING
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DROME|FlyBase=FBgn0001105|UniProtKB=P26308	Guanine nucleotide-binding protein subunit beta-1	IC	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00019	Endothelin signaling pathway	P00590	IP3 R	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P02771	Pyrimidine Metabolism	P03126	Nucleoside Phosphorylase	DEIRA|EnsemblGenome=DR_0443|UniProtKB=Q9RX72	Pyrimidine-nucleoside phosphorylase	ISS	10567266	PubMed	PTHR10515:SF0	THYMIDINE PHOSPHORYLASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	PANTR|Ensembl=ENSPTRG00000006342|UniProtKB=H2Q8A8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00029	Huntington disease	P00790	beta-Tubulin	IXOSC|EnsemblGenome=ISCW017133|UniProtKB=B7PA92	Beta tubulin	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=97255|UniProtKB=Q02566	Myosin-6	IC	10938134	PubMed	PTHR13140:SF721	MYOSIN-6
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	HUMAN|HGNC=11534|UniProtKB=Q15572	TATA box-binding protein-associated factor RNA polymerase I subunit C	ISS	604905	OMIM	PTHR15319:SF1	TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT C
P00006	Apoptosis signaling pathway	P00318	PKCs	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IDA	10747026	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	RAT|RGD=620351|UniProtKB=P18265	Glycogen synthase kinase-3 alpha	IDA	2164470	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	IC	15313841	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00059	p53 pathway	P04623	CBP	MOUSE|MGI=MGI=1276116|UniProtKB=B2RWS6	Histone acetyltransferase p300	ISS	10769018	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	RAT|RGD=1308423|UniProtKB=D3ZY89	Protein Taf8	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	XENTR|Xenbase=XB-GENE-1010483|UniProtKB=F7AF72	Uncharacterized protein	ISS	20112749	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P02785	Valine biosynthesis	P03217	Dihydroxy isovalerate reductoisomerase	STRCO|EnsemblGenome=CAB37590|UniProtKB=Q9Z565	Ketol-acid reductoisomerase 1	ISS			PTHR21371:SF1	KETOL-ACID REDUCTOISOMERASE, CHLOROPLASTIC
P05915	Opioid proenkephalin pathway	P05990	K+ channel	BOVIN|Ensembl=ENSBTAG00000047488|UniProtKB=G3N1D1	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04547	Ras	ANOGA|EnsemblGenome=AGAP002219|UniProtKB=Q7QK91	AGAP002219-PA	IDA	10684567	PubMed	PTHR24070:SF385	GTPASE HRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DROME|FlyBase=FBgn0011743|UniProtKB=P45891	Actin-like protein 53D	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04393	Ras Pathway	P04552	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00047	PDGF signaling pathway	P01162	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IGI	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00269	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	10875333	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00046	Oxidative stress response	P01122	TRX	PLAF7|EnsemblGenome=PF14_0545|UniProtKB=Q7KQL8	Thioredoxin	ISS			PTHR10438:SF360	THIOREDOXIN H9-RELATED
P00046	Oxidative stress response	P01135	p38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	TAS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00021	FGF signaling pathway	P00632	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02731	Biotin biosynthesis	P02857	Biotin synthase	SCHPO|PomBase=SPCC1235.02|UniProtKB=O59778	Biotin synthase	ISS			PTHR22976:SF1	BIOTIN SYNTHASE, MITOCHONDRIAL
P04393	Ras Pathway	P04572	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02777	Succinate to proprionate conversion	P03163	Methylmalonyl-CoA decarboxylase	SULSO|EnsemblGenome=SSO2463|UniProtKB=Q97VY8	Propionyl-CoA carboxylase beta subunit (PpcB)	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P00049	Parkinson disease	P01234	GRK	BOVIN|Gene=ADRBK1|UniProtKB=P21146	Beta-adrenergic receptor kinase 1	IDA	10852916	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MONDO|Ensembl=ENSMODG00000023429|UniProtKB=F6XI83	Uncharacterized protein	ISS	12441358	PubMed	PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01238	14-3-3	CHICK|Ensembl=ENSGALG00000010725|UniProtKB=Q5ZKC9	14-3-3 protein zeta	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00047	PDGF signaling pathway	P01162	MEK	CAEEL|WormBase=WBGene00003186|UniProtKB=Q10664	Dual specificity mitogen-activated protein kinase kinase mek-2	ISS	12024031	PubMed	PTHR24361:SF629	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1
P00056	VEGF signaling pathway	P01419	Ets	HUMAN|HGNC=3488|UniProtKB=P14921	Protein C-ets-1	IEP	15699632	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00021	FGF signaling pathway	P00633	Ras	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	ISS	22097630	PubMed	PTHR24070:SF189	GTPASE NRAS
P00018	EGF receptor signaling pathway	P00547	PP2A	MOUSE|MGI=MGI=1321161|UniProtKB=P62715	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	TAS	1171954	gi	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06824	CNP	MOUSE|MGI=MGI=97369|UniProtKB=Q61839	C-type natriuretic peptide	RCA			PTHR12167:SF2	C-TYPE NATRIURETIC PEPTIDE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MOUSE|MGI=MGI=87909|UniProtKB=P62737	Actin, aortic smooth muscle	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00010	B cell activation	P00402	Jnk	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00564	Rac	DICDI|dictyBase=DDB_G0277869|UniProtKB=P34144	Rho-related protein rac1A	IGI	12932731	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	HUMAN|HGNC=4580|UniProtKB=Q13002	Glutamate receptor ionotropic, kainate 2	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00029	Huntington disease	P00779	TBP	DROME|FlyBase=FBgn0010287|UniProtKB=Q27896	TBP-related factor	IPI	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	CHICK|Ensembl=ENSGALG00000009640|UniProtKB=F1P0I0	Muscarinic acetylcholine receptor	TAS	10069496	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00019	Endothelin signaling pathway	P00586	Gq	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00005	Angiogenesis	P00254	GTPase	XENTR|Xenbase=XB-GENE-478301|UniProtKB=Q6NVL3	Ras homolog gene family, member B	ISS	13679859	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MONDO|Ensembl=ENSMODG00000014736|UniProtKB=F6ZC55	Phosphoinositide phospholipase C	ISS			PTHR10336:SF84	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2
P05918	p38 MAPK pathway	P06031	p38alpha	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00054	Toll receptor signaling pathway	P01346	TLR	PANTR|Ensembl=ENSPTRG00000015984|UniProtKB=B3Y669	Toll-like receptor	ISS			PTHR24365:SF23	TOLL-LIKE RECEPTOR 10
P00059	p53 pathway	G04702	p53	MOUSE|MGI=MGI=98834|UniProtKB=P02340	Cellular tumor antigen p53	TAS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P02738	De novo purine biosynthesis	P02902	ADP reductase	DEIRA|EnsemblGenome=DR_B0108|UniProtKB=Q9RZL7	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT ALPHA
P04393	Ras Pathway	P04557	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	IDA	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	XENTR|Xenbase=XB-GENE-480347|UniProtKB=Q6P640	Actin, alpha cardiac muscle 1	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	RAT|RGD=62030|UniProtKB=P02564	Myosin-7	IEP	89264452	PubMed	PTHR13140:SF344	MYOSIN-7
P00036	Interleukin signaling pathway	P00968	Ikk	MACMU|Ensembl=ENSMMUG00000008351|UniProtKB=F7HRV5	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	ANOGA|Gene=AgaP_AGAP009115|UniProtKB=Q7PW25	Phosphoinositide phospholipase C (Fragment)	ISS	7822322	PubMed	PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	MACMU|Ensembl=ENSMMUG00000018272|UniProtKB=F7HEB8	Uncharacterized protein	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04398	p53 pathway feedback loops 2	P04661	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	1171954	gi	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P06587	Nicotine pharmacodynamics pathway	P06606	ADCY2	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=4401|UniProtKB=O14775	Guanine nucleotide-binding protein subunit beta-5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00020	FAS signaling pathway	P00616	Nuclear Lamin	MONDO|Ensembl=ENSMODG00000016946|UniProtKB=F6V6C6	Uncharacterized protein	ISS	11165516	PubMed	PTHR23239:SF158	PRELAMIN-A/C
P00030	Hypoxia response via HIF activation	P00819	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	RAT|RGD=3274|UniProtKB=P23377	Furin	IDA	10956649	PubMed	PTHR42884:SF1	FURIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CAEEL|WormBase=WBGene00001519|UniProtKB=Q9U7D5	Muscarinic acetylcholine receptor gar-3	IDA	11689554	PubMed	PTHR43914:SF8	MUSCARINIC ACETYLCHOLINE RECEPTOR GAR-3
P02738	De novo purine biosynthesis	P02907	dADP kinase	RAT|RGD=619880|UniProtKB=Q9QXL7	Nucleoside diphosphate kinase 7	ISS			PTHR43109:SF2	NUCLEOSIDE DIPHOSPHATE KINASE 7
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	PANTR|Ensembl=ENSPTRG00000019449|UniProtKB=H2QV01	Actin related protein 2/3 complex, subunit 1B, 41kDa	ISS	12932731	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P02728	Arginine biosynthesis	P02846	Ornithine carbamoyl transferase	SULSO|EnsemblGenome=SSO0871|UniProtKB=Q97ZM1	Ornithine carbamoyltransferase	ISS			PTHR11405:SF1	ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00025	Hedgehog signaling pathway	P00682	PKA	NEUCR|EnsemblGenome=EFNCRG00000004240|UniProtKB=Q01386	cAMP-dependent protein kinase regulatory subunit	ISS	91298951	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04664	cyclin E	PANTR|Ensembl=ENSPTRG00000010782|UniProtKB=H2R677	Cyclin E1	ISS	12628165	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00054	Toll receptor signaling pathway	P01369	MKK1	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	TAS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	BOVIN|Ensembl=ENSBTAG00000015670|UniProtKB=E1B7J7	Uncharacterized protein	ISS	7559398	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00010	B cell activation	P00380	fos	MACMU|Ensembl=ENSMMUG00000010574|UniProtKB=A5A6H2	C-fos	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	PANTR|Ensembl=ENSPTRG00000006218|UniProtKB=H2Q834	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MACMU|Ensembl=ENSMMUG00000009009|UniProtKB=F7H249	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF63	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	XENTR|Xenbase=XB-GENE-493937|UniProtKB=Q5M8T9	Actin, alpha 2, smooth muscle, aorta	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	HUMAN|HGNC=703|UniProtKB=Q92747	Actin-related protein 2/3 complex subunit 1A	ISS	12473693	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00005	Angiogenesis	P00221	JNK1	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00131	HAC1	HUMAN|HGNC=10064|UniProtKB=O75382	Tripartite motif-containing protein 3	IDA			PTHR44028:SF1	TRIPARTITE MOTIF-CONTAINING PROTEIN 3
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000016097|UniProtKB=E1B9S9	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00010	B cell activation	P00385	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00046	Oxidative stress response	P01137	MNK1/2	MOUSE|MGI=MGI=894279|UniProtKB=Q8CDB0	MAP kinase-interacting serine/threonine-protein kinase 2	ISS	9155017	PubMed	PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P00046	Oxidative stress response	P01135	p38	CAEEL|WormBase=WBGene00004056|UniProtKB=Q8MXI4	Mitogen-activated protein kinase pmk-2	TAS	11707292	PubMed	PTHR24055:SF154	MITOGEN-ACTIVATED PROTEIN KINASE PMK-2
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MONDO|Ensembl=ENSMODG00000009514|UniProtKB=F7EVK3	Uncharacterized protein	ISS	9819389	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00035	Interferon-gamma signaling pathway	P00961	STAT1	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	15825084	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P05915	Opioid proenkephalin pathway	P05994	G-protein	XENTR|Xenbase=XB-GENE-963560|UniProtKB=Q0VFC4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01386	TFIIEbeta	CANLF|Ensembl=ENSCAFG00000006489|UniProtKB=E2R5J2	Transcription initiation factor IIE subunit beta	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02772	Pyruvate metabolism	P03138	Malate Dehydrogenase	METJA|EnsemblGenome=MJ_1425|UniProtKB=Q58820	L-sulfolactate dehydrogenase	ISS	8688087	PubMed	PTHR11091:SF0	SUBFAMILY NOT NAMED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	BOVIN|Ensembl=ENSBTAG00000009702|UniProtKB=F1N775	Uncharacterized protein	IC	89264452	PubMed	PTHR13140:SF368	MYOSIN-8
P06664	Gonadotropin-releasing hormone receptor pathway	P06787	SMAD1/5/8	MOUSE|MGI=MGI=1328787|UniProtKB=P97454	Mothers against decapentaplegic homolog 5	RCA	9395284	PubMed	PTHR13703:SF36	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5
P00012	Cadherin signaling pathway	P00466	EGFR	RAT|RGD=2561|UniProtKB=P06494	Receptor tyrosine-protein kinase erbB-2	ISS	8393325	gi	PTHR24416:SF137	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MONDO|Ensembl=ENSMODG00000018204|UniProtKB=F6PGX6	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00047	PDGF signaling pathway	P01143	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	9298898	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	HUMAN|HGNC=4586|UniProtKB=Q13224	Glutamate receptor ionotropic, NMDA 2B	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00029	Huntington disease	P00796	Kainate receptor	BOVIN|Ensembl=ENSBTAG00000009269|UniProtKB=F1MCM2	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00057	Wnt signaling pathway	P01443	Phospholipase C	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IDA	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=17175|UniProtKB=Q9P212	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	7822322	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01084	CHT1	HUMAN|HGNC=11055|UniProtKB=P48029	Sodium- and chloride-dependent creatine transporter 1	ISS			PTHR11616:SF96	SODIUM- AND CHLORIDE-DEPENDENT CREATINE TRANSPORTER 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	CANLF|Ensembl=ENSCAFG00000004882|UniProtKB=F1PAE3	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P02747	Histidine biosynthesis	P02991	Histidinephosphate aminotransferase	STRCO|Gene=CAC38794|UniProtKB=Q93RW7	Putative aminotransferase	ISS			PTHR42885:SF1	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00057	Wnt signaling pathway	P01452	NFAT	CANLF|Ensembl=ENSCAFG00000011625|UniProtKB=F1PDD9	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	IC	3487386	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P05913	Enkephalin release	P05974	G-Protein (i)	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8972|UniProtKB=O00750	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	NEUCR|EnsemblGenome=EFNCRG00000006002|UniProtKB=Q7SBR2	Phosphoinositide phospholipase C	ISS			PTHR10336:SF82	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	BOVIN|Gene=ACSS3|UniProtKB=A7MB45	Acyl-CoA synthetase short-chain family member 3, mitochondrial	ISS			PTHR43347:SF3	ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL
P00006	Apoptosis signaling pathway	P00321	HSP70	HUMAN|HGNC=5232|UniProtKB=P0DMV8	Heat shock 70 kDa protein 1A	ISS	12150907	PubMed	PTHR19375:SF223	HEAT SHOCK 70 KDA PROTEIN 1A-RELATED
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	HUMAN|HGNC=4571|UniProtKB=P42261	Glutamate receptor 1	ISS	12941441	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	PANTR|Gene=CHRM3|UniProtKB=Q9N2A4	Muscarinic acetylcholine receptor M3	IDA	12181435	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02788	Xanthine and guanine salvage pathway	P03245	Guanine phosphoribosyl transferase	MACMU|Ensembl=ENSMMUG00000018728|UniProtKB=F6YAZ3	Uncharacterized protein	ISS			PTHR43340:SF5	PHOSPHORIBOSYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00543	ERK1-2	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	IGI	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00010	B cell activation	P00380	fos	MACMU|Ensembl=ENSMMUG00000010574|UniProtKB=A5A6H2	C-fos	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00053	T cell activation	P01332	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	TAS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01465	Ggamma	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00005	Angiogenesis	P00181	SHP2	MACMU|Ensembl=ENSMMUG00000013253|UniProtKB=F6ZJD8	Tyrosine-protein phosphatase non-receptor type	ISS	8096088	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CHICK|Ensembl=ENSGALG00000011248|UniProtKB=F1P354	Phosphoinositide phospholipase C	ISS			PTHR10336:SF84	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	HUMAN|HGNC=4593|UniProtKB=Q13255	Metabotropic glutamate receptor 1	IDA	8314195	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00274	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00089	Pen-2	BOVIN|Ensembl=ENSBTAG00000018593|UniProtKB=Q5G235	Gamma-secretase subunit PEN-2	IDA	12110170	PubMed	PTHR16318:SF0	GAMMA-SECRETASE SUBUNIT PEN-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	HUMAN|HGNC=132|UniProtKB=P60709	Actin, cytoplasmic 1	IC	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02916	dTMP kinase	ANOGA|EnsemblGenome=AGAP005260|UniProtKB=Q7PPZ1	AGAP005260-PA	ISS			PTHR10344:SF1	THYMIDYLATE KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05913	Enkephalin release	P05977	G-Protein (s)	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	DROME|FlyBase=FBgn0003189|UniProtKB=P05990	CAD protein	ISS			PTHR11405:SF5	CAD PROTEIN
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CHICK|Ensembl=ENSGALG00000011809|UniProtKB=F1NMB0	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	ORYSJ|EnsemblGenome=OS02G0120800|UniProtKB=Q6ZHA3	Rac-like GTP-binding protein 6	ISS			PTHR24072:SF261	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01472	Histone deacetylase	MACMU|Ensembl=ENSMMUG00000012588|UniProtKB=F6V5K8	Histone deacetylase	ISS	10485845	PubMed	PTHR10625:SF132	HISTONE DEACETYLASE 3
P00029	Huntington disease	P00805	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05918	p38 MAPK pathway	P06015	p38gamma	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00048	PI3 kinase pathway	P01202	p85	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00010	B cell activation	P00376	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00059	p53 pathway	G04701	PML	HUMAN|HGNC=9113|UniProtKB=P29590	Protein PML	IDA	14992722	PubMed	PTHR45211:SF1	PROTEIN PML
P00049	Parkinson disease	P01213	Cyclin E	PANTR|Ensembl=ENSPTRG00000010782|UniProtKB=H2R677	Cyclin E1	ISS	12729791	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00009	Axon guidance mediated by netrin	P00363	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	DROME|FlyBase=FBgn0022724|UniProtKB=Q9VWY6	Transcription initiation factor TFIID subunit 8	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	ARATH|TAIR=AT4G03330|UniProtKB=Q9ZQZ8	Syntaxin-123	IC			PTHR19957:SF198	SYNTAXIN-123
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	TAS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	G01574	ARF	HUMAN|HGNC=1790|UniProtKB=P55273	Cyclin-dependent kinase 4 inhibitor D	ISS			PTHR24148:SF47	CYCLIN-DEPENDENT KINASE 4 INHIBITOR B-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IDA	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01235	Fyn kinase	TAKRU|Ensembl=ENSTRUG00000003538|UniProtKB=H2S7D1	Tyrosine-protein kinase	ISS	11162638	PubMed	PTHR24418:SF242	TYROSINE-PROTEIN KINASE FYNB
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	STRPU|EnsemblGenome=SPU_012282|UniProtKB=W4Y969	Uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF369	ACTIN-42A
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	HUMAN|HGNC=11773|UniProtKB=P37173	TGF-beta receptor type-2	TAS	9759503	PubMed	PTHR23255:SF55	TGF-BETA RECEPTOR TYPE-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000003399|UniProtKB=H2Q383	Phosphoinositide-3-kinase, class 2, alpha polypeptide	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00049	Parkinson disease	P01241	TH	PANTR|Ensembl=ENSPTRG00000003173|UniProtKB=H2Q2W7	Uncharacterized protein	ISS	12814656	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00010	B cell activation	P00402	Jnk	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-050417-59|UniProtKB=Q15KE4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	RAT|RGD=1583498|UniProtKB=F1MAS3	Protein LOC100911840	ISS			PTHR23431:SF3	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5
P00019	Endothelin signaling pathway	P00570	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00029	Huntington disease	P00774	Dynein complex	MACMU|Ensembl=ENSMMUG00000005780|UniProtKB=F6VUB3	Uncharacterized protein	ISS	9454836	PubMed	PTHR10676:SF314	CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1
P06587	Nicotine pharmacodynamics pathway	P06610	CHRNB4	HUMAN|HGNC=1964|UniProtKB=P30926	Neuronal acetylcholine receptor subunit beta-4	TAS	11602335	PubMed	PTHR18945:SF385	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-4
P00021	FGF signaling pathway	P00645	Rac	MONDO|Ensembl=ENSMODG00000003244|UniProtKB=F6THF0	Uncharacterized protein	ISS	9254684	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00034	Integrin signalling pathway	P00944	Actin	BOVIN|Ensembl=ENSBTAG00000006189|UniProtKB=P63258	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04397	p53 pathway by glucose deprivation	P04640	p53	MACMU|Ensembl=ENSMMUG00000008639|UniProtKB=P56424	Cellular tumor antigen p53	TAS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	BOVIN|Ensembl=ENSBTAG00000018445|UniProtKB=E1BK87	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	MOUSE|MGI=MGI=99474|UniProtKB=Q91YI4	Beta-arrestin-2	ISS	9388255	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	IDA	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00051	TCA cycle	P01271	Fumarase	MACMU|Ensembl=ENSMMUG00000005667|UniProtKB=F6VWV9	Uncharacterized protein	ISS	227665	gi	PTHR11444:SF1	FUMARATE HYDRATASE, MITOCHONDRIAL
P00029	Huntington disease	P00796	Kainate receptor	BOVIN|Ensembl=ENSBTAG00000034854|UniProtKB=F1N246	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00020	FAS signaling pathway	P00608	Pro-Caspase3	MOUSE|MGI=MGI=107739|UniProtKB=P70677	Caspase-3	ISS	9323209	PubMed	PTHR10454:SF198	CASPASE-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00029	Huntington disease	P00786	ARF	MACMU|Ensembl=ENSMMUG00000006968|UniProtKB=F7DVH0	ADP-ribosylation factor 3	ISS	12932731	PubMed	PTHR11711:SF234	ADP-RIBOSYLATION FACTOR 1
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	12464394	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02755	Methylmalonyl pathway	P03033	Propionyl-CoA carboxylase	CAEBR|Gene=CBG14130|UniProtKB=A8XJD4	Protein CBR-PCCB-1	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=2136740|UniProtKB=Q91XZ4	Protein Pcdhb6	IDA	8120095	PubMed	PTHR24028:SF100	MCG141292-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CRYNJ|EnsemblGenome=CND03830|UniProtKB=Q5KI86	Uncharacterized protein	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	CRYNJ|EnsemblGenome=CNA03840|UniProtKB=Q5KP84	Protein serine/threonine kinase, putative	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01001	KA4	CHICK|Ensembl=ENSGALG00000006638|UniProtKB=R4GGL9	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	RCA	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00021	FGF signaling pathway	P00630	RKIP	RAT|RGD=62017|UniProtKB=P31044	Phosphatidylethanolamine-binding protein 1	IDA	7637590	PubMed	PTHR11362:SF10	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IDA	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	CHICK|Ensembl=ENSGALG00000017238|UniProtKB=F1NWG3	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P02771	Pyrimidine Metabolism	P03129	Aminotransferase	HUMAN|HGNC=23|UniProtKB=P80404	4-aminobutyrate aminotransferase, mitochondrial	IDA	8133261	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	MOUSE|MGI=MGI=87947|UniProtKB=P28650	Adenylosuccinate synthetase isozyme 1	ISS	10636885	PubMed	PTHR11846:SF2	ADENYLOSUCCINATE SYNTHETASE ISOZYME 1
P00037	Ionotropic glutamate receptor pathway	P01026	KA	CHICK|Ensembl=ENSGALG00000001172|UniProtKB=P19439	Probable glutamate receptor	ISS	11319238	PubMed	PTHR18966:SF282	GLUTAMATE RECEPTOR-RELATED
P02721	ATP synthesis	P02791	F1 alpha	DANRE|ZFIN=ZDB-GENE-060201-1|UniProtKB=Q08BA1	ATP synthase subunit alpha	ISS	11479684	PubMed	PTHR43089:SF5	ATP SYNTHASE SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01167	Ets	MOUSE|MGI=MGI=1353422|UniProtKB=Q9WTP3	SAM pointed domain-containing Ets transcription factor	ISS	15298723	PubMed	PTHR11849:SF182	SAM POINTED DOMAIN-CONTAINING ETS TRANSCRIPTION FACTOR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	BOVIN|Ensembl=ENSBTAG00000024507|UniProtKB=E1BNF2	Uncharacterized protein	ISS	12374786	PubMed	PTHR11767:SF17	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 3
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PANTR|Ensembl=ENSPTRG00000023373|UniProtKB=G2HHT2	Tubulin beta-2C chain	ISS	12932731	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000013587|UniProtKB=F7AZ16	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF33	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-3
P00034	Integrin signalling pathway	P00927	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05918	p38 MAPK pathway	P06029	p38beta	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	RCA	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00056	VEGF signaling pathway	P01413	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00805	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00053	T cell activation	P01331	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IDA	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00029	Huntington disease	P00807	Actin	BOVIN|Ensembl=ENSBTAG00000014614|UniProtKB=P62739	Actin, aortic smooth muscle	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	PHYPA|Gene=PHYPADRAFT_183198|UniProtKB=A9SBU0	Predicted protein	ISS	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CANLF|Ensembl=ENSCAFG00000008653|UniProtKB=F1PE26	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=1561991|UniProtKB=A0A096MJW8	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF51	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-1
P00059	p53 pathway	G01579	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02771	Pyrimidine Metabolism	P03124	Methylmalonate Semialdehyde Dehydrogenase	PANTR|Ensembl=ENSPTRG00000006531|UniProtKB=H2Q8L3	Uncharacterized protein	ISS	1527093	PubMed	PTHR43866:SF3	METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE  ACYLATING , MITOCHONDRIAL
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00019	Endothelin signaling pathway	P00572	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00012	Cadherin signaling pathway	P00475	Frizzled	DANRE|ZFIN=ZDB-GENE-990415-220|UniProtKB=Q9W6E3	Frizzled homolog 10	IDA	8717036	PubMed	PTHR11309:SF86	FRIZZLED-10
P00012	Cadherin signaling pathway	P00474	Wnt	DROME|FlyBase=FBgn0010453|UniProtKB=P40589	Protein Wnt-4	ISS	11266476	PubMed	PTHR12027:SF102	PROTEIN WNT-4
P00059	p53 pathway	P01486	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00589	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02736	Coenzyme A biosynthesis	P02885	Pantothenate kinase	CAEEL|WormBase=WBGene00006862|UniProtKB=Q18580	PaNtothenate Kinase	ISS			PTHR12280:SF3	PANTOTHENATE KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	TAKRU|Ensembl=ENSTRUG00000016241|UniProtKB=H2UX35	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF305	PROTEIN KINASE C
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00030	Hypoxia response via HIF activation	P00819	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00568	PKC	DANRE|ZFIN=ZDB-GENE-030131-6503|UniProtKB=Q7ZUC5	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF297	PROTEIN KINASE C DELTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00012	Cadherin signaling pathway	P00477	GSK3beta	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00019	Endothelin signaling pathway	P00586	Gq	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05918	p38 MAPK pathway	P06025	SRF	MONDO|Ensembl=ENSMODG00000018981|UniProtKB=F7FP88	Uncharacterized protein	ISS	8660892	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00052	TGF-beta signaling pathway	P01275	P38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	TAS	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ORYSJ|EnsemblGenome=OS06G0699400|UniProtKB=Q5Z859	Mitogen-activated protein kinase 4	ISS	7341300	gi	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00010	B cell activation	P00375	Calmodulin	MONDO|Ensembl=ENSMODG00000002696|UniProtKB=F7CY56	Uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF335	CALMODULIN, STRIATED MUSCLE
P00009	Axon guidance mediated by netrin	P00364	cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00034	Integrin signalling pathway	P00912	Arp2/3	HUMAN|HGNC=703|UniProtKB=Q92747	Actin-related protein 2/3 complex subunit 1A	IPI	12963527	gi	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	G04714	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=1307591|UniProtKB=D3ZM08	Protein Pcdhb14	ISS	8120095	PubMed	PTHR24028:SF139	PROTOCADHERIN BETA-14
P00052	TGF-beta signaling pathway	P01276	Co-Smads	XENTR|Xenbase=XB-GENE-485691|UniProtKB=F7BDU6	Mothers against decapentaplegic homolog (Fragment)	ISS	9395284	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00034	Integrin signalling pathway	P00907	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00547	PP2A	CHICK|Ensembl=ENSGALG00000011840|UniProtKB=F1NLM6	Uncharacterized protein	ISS	11007767	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	HUMAN|HGNC=175|UniProtKB=P37023	Serine/threonine-protein kinase receptor R3	TAS	9395284	PubMed	PTHR23255:SF66	SERINE/THREONINE-PROTEIN KINASE RECEPTOR R3
P00059	p53 pathway	G01569	Maspin	RAT|RGD=69342|UniProtKB=P70564	Serpin B5	TAS	10692390	PubMed	PTHR11461:SF55	SERPIN B5
P02779	Thiamin biosynthesis	P03173	Thiamin phosphate synthase	BACSU|EnsemblGenome=BSU38290|UniProtKB=P39594	Thiamine-phosphate synthase	ISS			PTHR20857:SF15	THIAMINE BIOSYNTHETIC BIFUNCTIONAL ENZYME
P00047	PDGF signaling pathway	P01142	p90RSK	HUMAN|HGNC=10434|UniProtKB=O75582	Ribosomal protein S6 kinase alpha-5	ISS	6755374	gi	PTHR24351:SF115	RIBOSOMAL PROTEIN S6 KINASE ALPHA-5
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01318	PKC-theta	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00117	E-cadherin C-terminal fragment	RAT|RGD=621089|UniProtKB=F1LMI3	Cadherin 3, type 1, P-cadherin (Placental)	ISS	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P00006	Apoptosis signaling pathway	P00263	TRAIL	PANTR|Ensembl=ENSPTRG00000015631|UniProtKB=G2HF74	Tumor necrosis factor ligand superfamily member 10	ISS	12421926	PubMed	PTHR11471:SF27	TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 10
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00045	Notch signaling pathway	P01103	Next	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	CANLF|Ensembl=ENSCAFG00000007882|UniProtKB=E2QX69	Uncharacterized protein	ISS			PTHR42884:SF14	NEUROENDOCRINE CONVERTASE 1
P00054	Toll receptor signaling pathway	P01338	IkappaB	CANLF|Ensembl=ENSCAFG00000013418|UniProtKB=E2RML9	Uncharacterized protein	ISS	14665694	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00005	Angiogenesis	P00223	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01199	Galpha	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	IC	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CAEEL|WormBase=WBGene00003774|UniProtKB=G5EGQ9	NMDA class glutamate Receptor	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00057	Wnt signaling pathway	P01451	Galpha	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	IDA	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00057	Wnt signaling pathway	P01448	CBP	MOUSE|MGI=MGI=1276116|UniProtKB=B2RWS6	Histone acetyltransferase p300	ISS	10769018	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00006	Apoptosis signaling pathway	P00303	c-Jun	XENTR|Xenbase=XB-GENE-482228|UniProtKB=F6RYL1	Uncharacterized protein	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00036	Interleukin signaling pathway	P00977	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	CHICK|Gene=MYH11|UniProtKB=P10587	Myosin-11	ISS	89264452	PubMed	PTHR13140:SF335	MYOSIN-11
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00053	T cell activation	P01300	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00060	Ubiquitin proteasome pathway	P01491	E2	MACMU|Ensembl=ENSMMUG00000011201|UniProtKB=F6URZ8	Uncharacterized protein	ISS			PTHR24068:SF48	UBIQUITIN-CONJUGATING ENZYME E2 D3
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00384	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02781	Threonine biosynthesis	P03190	Threonine synthase	SCHPO|PomBase=SPAC9E9.06c|UniProtKB=Q42598	Threonine synthase	ISS	9501991	PubMed	PTHR42690:SF1	THREONINE SYNTHASE-LIKE 2
P00046	Oxidative stress response	P01129	JNK1/2	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00049	Parkinson disease	P01211	ERK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00571	Pro ET1-4	CANLF|Ensembl=ENSCAFG00000009794|UniProtKB=P13206	Endothelin-1	ISS			PTHR13874:SF10	ENDOTHELIN-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CAEEL|WormBase=WBGene00001187|UniProtKB=Q8MQA1	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	IC	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P02751	Lysine biosynthesis	P03009	Aspartokinase	LEPIN|EnsemblGenome=LA_0693|UniProtKB=Q8F865	Aspartokinase	ISS			PTHR21499:SF3	ASPARTOKINASE
P00048	PI3 kinase pathway	P01194	S6K	CANLF|Ensembl=ENSCAFG00000017679|UniProtKB=E2RMD8	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CHICK|Gene=ACTA2|UniProtKB=P08023	Actin, aortic smooth muscle	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P02747	Histidine biosynthesis	P02988	Histidinal dehydrogenase	ECOLI|EcoGene=EG10447|UniProtKB=P06988	Histidinol dehydrogenase	ISS			PTHR21256:SF2	HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT1G10210|UniProtKB=Q39021	Mitogen-activated protein kinase 1	ISS	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00029	Huntington disease	P00788	Calpain	MOUSE|MGI=MGI=88264|UniProtKB=O08529	Calpain-2 catalytic subunit	IDA	11675509	PubMed	PTHR10183:SF268	CALPAIN-2 CATALYTIC SUBUNIT
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CAEBR|Gene=CBG17587|UniProtKB=A8XRA5	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00021	FGF signaling pathway	P00641	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00053	T cell activation	P01294	NFAT	HUMAN|HGNC=7776|UniProtKB=Q13469	Nuclear factor of activated T-cells, cytoplasmic 2	IGI	12015605	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00053	T cell activation	P01316	MHC-antigen	CHICK|Ensembl=ENSGALG00000000158|UniProtKB=A5HUL6	MHC class II M alpha chain	IPI	73139	PubMed	PTHR19944:SF50	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DM ALPHA CHAIN
P00034	Integrin signalling pathway	P00907	ERK	MONDO|Ensembl=ENSMODG00000009766|UniProtKB=F6TFL4	Uncharacterized protein	ISS	8444355	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02757	O-antigen biosynthesis	P03046	dTDP-glucose pyrophosphorylase	THEMA|EnsemblGenome=TM_0862|UniProtKB=Q9WZW6	Glucose-1-phosphate thymidylyltransferase	ISS			PTHR42883:SF2	SUBFAMILY NOT NAMED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	PANTR|Ensembl=ENSPTRG00000014418|UniProtKB=H2QLS0	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04393	Ras Pathway	P04557	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	IDA	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00046	Oxidative stress response	P01137	MNK1/2	DANRE|ZFIN=ZDB-GENE-030829-2|UniProtKB=B0S6F4	Uncharacterized protein	ISS			PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	HUMAN|HGNC=705|UniProtKB=O15144	Actin-related protein 2/3 complex subunit 2	ISS	10940259	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00019	Endothelin signaling pathway	P00572	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IGI	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00021	FGF signaling pathway	P00648	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00030	Hypoxia response via HIF activation	P00825	Thioredoxin	SCHMA|EnsemblGenome=Smp_008070|UniProtKB=Q8T9N5	Thioredoxin	ISS			PTHR10438:SF284	THIOREDOXIN-LIKE PROTEIN 1
P00018	EGF receptor signaling pathway	P00563	Gab	BOVIN|Ensembl=ENSBTAG00000001209|UniProtKB=E1BBH1	Uncharacterized protein	ISS			PTHR12156:SF21	PLECKSTRIN HOMOLOGY-LIKE DOMAIN FAMILY B MEMBER 2
P00021	FGF signaling pathway	P00624	14-3-3	TAKRU|Ensembl=ENSTRUG00000004697|UniProtKB=H2SFG7	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00036	Interleukin signaling pathway	P00968	Ikk	BOVIN|Ensembl=ENSBTAG00000007599|UniProtKB=Q95KV0	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00875	GEF	CANLF|Ensembl=ENSCAFG00000018590|UniProtKB=E2RGT8	Uncharacterized protein	ISS	10661401	PubMed	PTHR22826:SF112	PROTO-ONCOGENE VAV
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04393	Ras Pathway	P04568	MKK3/6	CANLF|Ensembl=ENSCAFG00000010758|UniProtKB=E2R7W7	Uncharacterized protein	RCA			PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	ORNAN|Ensembl=ENSOANG00000002719|UniProtKB=F6UAT6	Uncharacterized protein	ISS			PTHR11699:SF207	ALDEHYDE DEHYDROGENASE X, MITOCHONDRIAL
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_58093|UniProtKB=C3Z4K3	Putative uncharacterized protein	IDA	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00990	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	98189216	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02769	Purine metabolism	P03117	5'-AMP Deaminase	ARATH|TAIR=AT2G38280|UniProtKB=O80452	AMP deaminase	ISS	10617197	PubMed	PTHR11359:SF0	AMP DEAMINASE, ISOFORM K
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01443	Phospholipase C	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF330	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00254	GTPase	HUMAN|HGNC=667|UniProtKB=P61586	Transforming protein RhoA	ISS	12039949	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00029	Huntington disease	P00778	NMDA receptor	BOVIN|Ensembl=ENSBTAG00000047202|UniProtKB=G3N3K3	Uncharacterized protein	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	RAT|RGD=619978|UniProtKB=P67874	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00010	B cell activation	P00371	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00717	Phosphorylase b	BOVIN|Gene=PYGM|UniProtKB=P79334	Glycogen phosphorylase, muscle form	IDA	4318782	PubMed	PTHR11468:SF13	GLYCOGEN PHOSPHORYLASE, MUSCLE FORM
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IPI	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02771	Pyrimidine Metabolism	P03129	Aminotransferase	BOVIN|Gene=ABAT|UniProtKB=Q9BGI0	4-aminobutyrate aminotransferase, mitochondrial	ISS	10989446	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	RAT|RGD=68385|UniProtKB=D4A055	Calcium channel, voltage-dependent, beta 4 subunit, isoform CRA_b	IC			PTHR11824:SF7	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MACMU|Ensembl=ENSMMUG00000004886|UniProtKB=F7AGT9	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	97442349	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00624	14-3-3	ORYSJ|EnsemblGenome=OS11G0546900|UniProtKB=Q2R2W2	14-3-3-like protein GF14-D	ISS	20493542	PubMed	PTHR18860:SF34	SUBFAMILY NOT NAMED
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	RAT|RGD=70497|UniProtKB=Q05982	Nucleoside diphosphate kinase A	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P00036	Interleukin signaling pathway	P00990	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01284	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00640	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IGI	12660731	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P02736	Coenzyme A biosynthesis	P02884	Dephospho-CoA kinase	CAEBR|Gene=CBG10005|UniProtKB=A8XA56	Protein CBG10005	ISS			PTHR10695:SF35	DEPHOSPHO-COA KINASE DOMAIN-CONTAINING PROTEIN
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	CHICK|Ensembl=ENSGALG00000006576|UniProtKB=E1BUE5	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT1G01560|UniProtKB=Q9LMM5	Mitogen-activated protein kinase 11	ISS	10851062	PubMed	PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P05916	Opioid prodynorphin pathway	P06001	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00012	Cadherin signaling pathway	P00471	Cadherin	CHICK|Gene=CDH7|UniProtKB=Q90763	Cadherin-7	IDA	8120095	PubMed	PTHR24027:SF91	CADHERIN-7
P00036	Interleukin signaling pathway	P00979	MAPKAPK2	BOVIN|Ensembl=ENSBTAG00000038107|UniProtKB=F1MCX5	Uncharacterized protein	ISS	8262198	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00005	Angiogenesis	P00189	Fzd	ORNAN|Ensembl=ENSOANG00000004982|UniProtKB=F7DIA9	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF34	FRIZZLED-2
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=12775|UniProtKB=O00744	Protein Wnt-10b	IDA	8717036	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=37275|UniProtKB=A4FU28	cTAGE family member 9	IC			PTHR23158:SF53	CTAGE FAMILY MEMBER 15-RELATED
P00021	FGF signaling pathway	P00624	14-3-3	DANRE|ZFIN=ZDB-GENE-061023-2|UniProtKB=E7F354	Uncharacterized protein	ISS	22165492	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	PANTR|Ensembl=ENSPTRG00000003141|UniProtKB=H2Q2W2	Uncharacterized protein	ISS			PTHR23431:SF3	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5
P00006	Apoptosis signaling pathway	P00310	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IDA	129387	gi	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00006	Apoptosis signaling pathway	P00303	c-Jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00023	General transcription regulation	P00658	TBP-associated factors	CANLF|Ensembl=ENSCAFG00000014601|UniProtKB=E2RFB9	Uncharacterized protein	ISS			PTHR10221:SF12	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MACMU|Ensembl=ENSMMUG00000009763|UniProtKB=F6ZIC3	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF368	MYOSIN-8
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	PANTR|Ensembl=ENSPTRG00000039733|UniProtKB=H2RDP9	Actin-related protein 2/3 complex subunit 4	ISS	5031595	gi	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00018	EGF receptor signaling pathway	P00539	14-3-3	ORNAN|Ensembl=ENSOANG00000007305|UniProtKB=F6XW91	Uncharacterized protein	ISS	12861023	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00015	Circadian clock system	G01497	cry	PANTR|Ensembl=ENSPTRG00000005396|UniProtKB=H2Q6S7	Cryptochrome 1 (Photolyase-like)	ISS	14507900	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00005	Angiogenesis	P00193	SOS-1	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BRAFL|Gene=BRAFLDRAFT_220697|UniProtKB=C3ZSF0	Putative uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00021	FGF signaling pathway	P00648	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	7492337	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00302	ATF	HUMAN|HGNC=791|UniProtKB=P18850	Cyclic AMP-dependent transcription factor ATF-6 alpha	ISS	11390664	PubMed	PTHR22952:SF116	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-6 ALPHA
P00054	Toll receptor signaling pathway	P01358	ERK1	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00007	Axon guidance mediated by semaphorins	P00328	plexinB1	HUMAN|HGNC=9103|UniProtKB=O43157	Plexin-B1	ISS			PTHR22625:SF36	PLEXIN-B1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MOUSE|MGI=MGI=95790|UniProtKB=Q01776	Gonadotropin-releasing hormone receptor	IDA	1333052	PubMed	PTHR24241:SF22	GONADOTROPIN-RELEASING HORMONE RECEPTOR
P00036	Interleukin signaling pathway	P00973	PKB	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS			PTHR24356:SF310	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00907	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	IDA	1169551	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00474	Wnt	MACMU|Ensembl=ENSMMUG00000020809|UniProtKB=F7H7P8	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P00005	Angiogenesis	P00218	STAT1	HUMAN|HGNC=11362|UniProtKB=P42224	Signal transducer and activator of transcription 1-alpha/beta	IDA	14755057	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	RAT|RGD=1589741|UniProtKB=P56700	Regulator of G-protein signaling 16	ISS	8756726	PubMed	PTHR10845:SF187	REGULATOR OF G-PROTEIN SIGNALING 16
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	TAKRU|Ensembl=ENSTRUG00000016101|UniProtKB=H2UW32	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00019	Endothelin signaling pathway	P00577	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IC	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IGI	14526383	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000008719|UniProtKB=F1MZX0	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00379	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01358	ERK1	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00165	E-cadherin N-terminal fragment	HUMAN|HGNC=1748|UniProtKB=P12830	Cadherin-1	TAS	8120095	PubMed	PTHR24027:SF319	CADHERIN-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00050	Plasminogen activating cascade	P01263	pro-MMP-1	BOVIN|Gene=MMP1|UniProtKB=P28053	Interstitial collagenase	ISS	12834808	PubMed	PTHR10201:SF151	INTERSTITIAL COLLAGENASE
P02770	Pyridoxal phosphate salvage pathway	P03120	Pyridoxamine-5-phosphate oxidase	SCHPO|PomBase=SPAC1093.02|UniProtKB=Q9UTQ1	Probable pyridoxamine 5'-phosphate oxidase	ISS	11859360	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00018	EGF receptor signaling pathway	P00545	JNK1-3	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00029	Huntington disease	P00797	p53	RAT|RGD=620863|UniProtKB=Q9JJP6	Tumor protein 63	TAS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	NAS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00049	Parkinson disease	P01219	SAPK	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	8920915	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00034	Integrin signalling pathway	P00951	Jnk	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00186	FGFR-1	CANLF|Ensembl=ENSCAFG00000005970|UniProtKB=E2R186	Fibroblast growth factor receptor	ISS	2544996	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00053	T cell activation	P01306	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00012	Cadherin signaling pathway	P00474	Wnt	DANRE|ZFIN=ZDB-GENE-051129-1|UniProtKB=Q4JLT0	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	BOVIN|Gene=CACNB1|UniProtKB=Q9MZL7	Voltage-dependent L-type calcium channel subunit beta-1	IC	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04393	Ras Pathway	P04559	Rac	ORYSJ|EnsemblGenome=OS02G0120800|UniProtKB=Q6ZHA3	Rac-like GTP-binding protein 6	ISS	21948222	PubMed	PTHR24072:SF261	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	XENTR|Xenbase=XB-GENE-854877|UniProtKB=F7C949	Presenilin	ISS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00057	Wnt signaling pathway	P01465	Ggamma	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IGI	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00187	beta catenin	HUMAN|HGNC=2514|UniProtKB=P35222	Catenin beta-1	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00049	Parkinson disease	P01211	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	RCA	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04556	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00029	Huntington disease	P00774	Dynein complex	PANTR|Ensembl=ENSPTRG00000009444|UniProtKB=H2QDI5	Dynein, light chain, LC8-type 2	ISS	9454836	PubMed	PTHR11886:SF35	DYNEIN LIGHT CHAIN 2, CYTOPLASMIC
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IDA	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00539	14-3-3	CANLF|Ensembl=ENSCAFG00000013549|UniProtKB=E2QVP6	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	RAT|RGD=2347|UniProtKB=P20420	Neuronal acetylcholine receptor subunit alpha-5	ISS	85270494	PubMed	PTHR18945:SF76	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04569	Cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00034	Integrin signalling pathway	P00924	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	3449797	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00034	Integrin signalling pathway	P00925	MEK	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MOUSE|MGI=MGI=88396|UniProtKB=P12657	Muscarinic acetylcholine receptor M1	TAS	12181435	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P05731	GABA-B receptor II signaling	P05754	Ggamma	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CAEBR|Gene=CBG17587|UniProtKB=A8XRA5	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00005	Angiogenesis	P00223	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00049	Parkinson disease	P01211	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	TAKRU|Ensembl=ENSTRUG00000010579|UniProtKB=H2TPU7	Uncharacterized protein	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00048	PI3 kinase pathway	P01182	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00016	Cytoskeletal regulation by Rho GTPase	P00508	Cofilin	MACMU|Ensembl=ENSMMUG00000019016|UniProtKB=F6RBB3	Uncharacterized protein	ISS			PTHR11913:SF17	COFILIN-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=7603|UniProtKB=Q9ULV0	Unconventional myosin-Vb	ISS			PTHR13140:SF356	UNCONVENTIONAL MYOSIN-VB
P00049	Parkinson disease	P01236	Casein kinase II	MACMU|Ensembl=ENSMMUG00000031224|UniProtKB=F7CKT2	Uncharacterized protein	ISS	10806215	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008422|UniProtKB=F6VUT7	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	TAS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00060	Ubiquitin proteasome pathway	P01490	E3	CANLF|Ensembl=ENSCAFG00000010110|UniProtKB=F1PBV3	Uncharacterized protein	ISS			PTHR11254:SF301	UBIQUITIN-PROTEIN LIGASE E3A
P04393	Ras Pathway	P04543	MEKK1/4	RAT|RGD=1311192|UniProtKB=A0A0G2K3R1	Protein Map3k4	ISS	11730323	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00020	FAS signaling pathway	P00600	PARP	BOVIN|Ensembl=ENSBTAG00000009374|UniProtKB=G3N186	Poly [ADP-ribose] polymerase	ISS	12101391	PubMed	PTHR10459:SF60	POLY  ADP-RIBOSE  POLYMERASE 2
P02783	Tryptophan biosynthesis	P03209	Anthranilate phosphoribosyl transferase	ARATH|TAIR=AT5G57890|UniProtKB=Q9FJM5	Anthranilate synthase beta subunit 2, chloroplastic	ISS			PTHR43418:SF6	ANTHRANILATE SYNTHASE BETA SUBUNIT-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00846	JAK	CANLF|Ensembl=ENSCAFG00000002102|UniProtKB=E2RPW6	Tyrosine-protein kinase	ISS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00004	Alzheimer disease-presenilin pathway	P00178	BACE-1 pro-domain	PANTR|Ensembl=ENSPTRG00000004324|UniProtKB=H2Q4U8	Beta-site APP-cleaving enzyme 1	ISS	10531052	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	MACMU|Ensembl=ENSMMUG00000022872|UniProtKB=F6WMJ4	Low-density lipoprotein receptor-related protein 3	ISS	11907044	PubMed	PTHR44062:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 3
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00048	PI3 kinase pathway	P01189	PTEN	TAKRU|Ensembl=ENSTRUG00000009851|UniProtKB=H2TJ90	Uncharacterized protein	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00017	DNA replication	P00527	Histones	MACMU|Ensembl=ENSMMUG00000031349|UniProtKB=H9H5A2	Histone H3	ISS	12413958	PubMed	PTHR11426:SF169	HISTONE H3
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	ORYSJ|EnsemblGenome=OS06G0699400|UniProtKB=Q5Z859	Mitogen-activated protein kinase 4	TAS			PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00898	FKHR	BOVIN|Ensembl=ENSBTAG00000011234|UniProtKB=F1N4K5	Uncharacterized protein	ISS	14775847	gi	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00060	Ubiquitin proteasome pathway	P01491	E2	BOVIN|Ensembl=ENSBTAG00000020796|UniProtKB=Q2TA10	Ubiquitin-conjugating enzyme E2 D1	ISS			PTHR24068:SF36	UBIQUITIN-CONJUGATING ENZYME E2 D1
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06841	gnaq/11	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	RCA	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	DANRE|ZFIN=ZDB-GENE-040426-1784|UniProtKB=Q6PBJ2	Cilia- and flagella-associated protein 20	ISS			PTHR12458:SF8	CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00977	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00005	Angiogenesis	P00223	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00025	Hedgehog signaling pathway	P00690	Cubitus interruptus	PANTR|Ensembl=ENSPTRG00000005133|UniProtKB=H2Q6B3	Uncharacterized protein	ISS			PTHR19818:SF2	ZINC FINGER PROTEIN GLI1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	PANTR|Ensembl=ENSPTRG00000014843|UniProtKB=Q9TV16	C-X-C chemokine receptor type 6	ISS	2209288	gi	PTHR10489:SF705	C-X-C CHEMOKINE RECEPTOR TYPE 6
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	MOUSE|MGI=MGI=1196616|UniProtKB=O08674	Recombining binding protein suppressor of hairless-like protein	NAS	12681948	PubMed	PTHR10665:SF2	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS-LIKE PROTEIN
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IGI	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	RAT|RGD=1308352|UniProtKB=D4A5E7	Inhibitor of kappaB kinase epsilon (Predicted)	ISS	11238099	PubMed	PTHR22969:SF10	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT EPSILON
P06664	Gonadotropin-releasing hormone receptor pathway	P06859	GATA2/4	MOUSE|MGI=MGI=95664|UniProtKB=Q08369	Transcription factor GATA-4	RCA			PTHR10071:SF154	TRANSCRIPTION FACTOR GATA-4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	CANLF|Ensembl=ENSCAFG00000008396|UniProtKB=F1P9Z4	Uncharacterized protein	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00024	Glycolysis	P00676	Glyceraldehyde 3-phosphate dehydrogenase	ARATH|TAIR=AT3G04120|UniProtKB=P25858	Glyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic	RCA			PTHR10836:SF60	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE GAPC1, CYTOSOLIC
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DANRE|ZFIN=ZDB-GENE-030131-55|UniProtKB=Q6XNL8	Actin	IDA	14684598	PubMed	PTHR11937:SF263	ACTIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	RAT|RGD=1593249|UniProtKB=D3ZMQ3	Protein Itga4	ISS	11035110	PubMed	PTHR23220:SF78	INTEGRIN ALPHA-4
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MACMU|Ensembl=ENSMMUG00000016376|UniProtKB=F7G2W1	Uncharacterized protein	ISS	12566458	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P04393	Ras Pathway	P04552	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	CANLF|Ensembl=ENSCAFG00000004956|UniProtKB=E2REH3	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	NAS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00029	Huntington disease	P00780	Microtubule	BOVIN|Ensembl=ENSBTAG00000025274|UniProtKB=Q3MHM5	Tubulin beta-4B chain	ISS	9454836	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00029	Huntington disease	P00783	Rab8	MOUSE|MGI=MGI=96960|UniProtKB=P55258	Ras-related protein Rab-8A	RCA			PTHR24073:SF635	RAS-RELATED PROTEIN RAB-8A
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IC	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00545	JNK1-3	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00019	Endothelin signaling pathway	P00589	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IGI	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04556	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	IDA	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	CAEEL|WormBase=WBGene00004391|UniProtKB=Q03604	Ribonucleoside-diphosphate reductase large subunit	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	DANRE|ZFIN=ZDB-GENE-070112-342|UniProtKB=A1L271	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00029	Huntington disease	P00805	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	G01511	SPRY	HUMAN|HGNC=15533|UniProtKB=Q9C004	Protein sprouty homolog 4	ISS	99264295	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	TAS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00052	TGF-beta signaling pathway	P01275	P38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	TAS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000023202|UniProtKB=F7EU36	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	NEUCR|EnsemblGenome=EFNCRG00000003892|UniProtKB=Q9UUY8	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	ANOGA|EnsemblGenome=AGAP011138|UniProtKB=Q5TVZ3	AGAP011138-PA (Fragment)	IC			PTHR13140:SF696	MYOSIN HEAVY CHAIN-LIKE, ISOFORM B
P00036	Interleukin signaling pathway	P00996	STAT	MONDO|Ensembl=ENSMODG00000028212|UniProtKB=F7BYN4	Signal transducer and activator of transcription	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00047	PDGF signaling pathway	P01142	p90RSK	CAEBR|Gene=CBG12516|UniProtKB=A8XFY3	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF110	RIBOSOMAL PROTEIN S6 KINASE II, ISOFORM A
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	LEIMA|EnsemblGenome=LmjF.35.4010|UniProtKB=Q9GNR4	Protein kinase A catalytic subunit isoform 1	ISS	14744463	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00084	X11alpha	BOVIN|Ensembl=ENSBTAG00000008877|UniProtKB=F1MYC3	Uncharacterized protein	ISS	9614075	PubMed	PTHR12345:SF14	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MONDO|Ensembl=ENSMODG00000020977|UniProtKB=F6S5B1	Uncharacterized protein (Fragment)	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00018	EGF receptor signaling pathway	P00564	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	TAS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02922	Orotate phosphoribosyltransferase	PYRAE|EnsemblGenome=PAE3264|UniProtKB=Q8ZTG3	Orotate phosphoribosyltransferase	ISS			PTHR19278:SF49	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00935	ILK	DROME|FlyBase=FBgn0028427|UniProtKB=Q9V400	Integrin linked kinase, isoform A	ISS			PTHR44344:SF1	INTEGRIN-LINKED PROTEIN KINASE
P05730	Endogenous cannabinoid signaling	P05746	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00005	Angiogenesis	P00186	FGFR-1	ORNAN|Ensembl=ENSOANG00000003252|UniProtKB=F6SM70	Fibroblast growth factor receptor	ISS	2544996	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IGI	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00048	PI3 kinase pathway	P01179	PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P02738	De novo purine biosynthesis	P02891	GDP kinase	PANTR|Ensembl=ENSPTRG00000005528|UniProtKB=H2Q705	Nucleoside diphosphate kinase	ISS			PTHR11349:SF68	NUCLEOSIDE DIPHOSPHATE KINASE-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	ARATH|TAIR=AT3G55940|UniProtKB=Q9LY51	Phosphoinositide phospholipase C 7	ISS			PTHR10336:SF92	PHOSPHOINOSITIDE PHOSPHOLIPASE C 2-RELATED
P00034	Integrin signalling pathway	P00948	Rho	DANRE|ZFIN=ZDB-GENE-010319-40|UniProtKB=Q6PC71	Rho family GTPase 3a	ISS	11973360	PubMed	PTHR24072:SF24	RHO-RELATED GTP-BINDING PROTEIN RHOE
P00005	Angiogenesis	P00219	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00029	Huntington disease	P00805	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00206	Wnt	RAT|RGD=1304988|UniProtKB=A0A0G2K6Q8	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00049	Parkinson disease	P01241	TH	RAT|RGD=3853|UniProtKB=P04177	Tyrosine 3-monooxygenase	TAS	191290	OMIM	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2747|UniProtKB=P35349	Metabotropic glutamate receptor 6	IDA	12351712	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P06587	Nicotine pharmacodynamics pathway	P06593	CHRNA5	RAT|RGD=2347|UniProtKB=P20420	Neuronal acetylcholine receptor subunit alpha-5	IDA	85270494	PubMed	PTHR18945:SF76	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5
P05917	Opioid proopiomelanocortin pathway	P06007	alpha-MSH	RAT|RGD=3366|UniProtKB=P01194	Pro-opiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	15313841	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00018	EGF receptor signaling pathway	P00556	PLCgamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00018	EGF receptor signaling pathway	P00552	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00052	TGF-beta signaling pathway	P01284	JNK	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	TAS	11707292	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00018	EGF receptor signaling pathway	P00557	PI3K	CANAL|CGD=CAL0068551|UniProtKB=Q5AAR9	Phosphatidylinositol 3-kinase	IGI	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IC	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	ORNAN|Ensembl=ENSOANG00000003489|UniProtKB=F7FSE3	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00010	B cell activation	P00376	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00057	Wnt signaling pathway	P01443	Phospholipase C	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00059	p53 pathway	P01480	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	IGI	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00021	FGF signaling pathway	P00647	SHP2	MOUSE|MGI=MGI=99511|UniProtKB=P35235	Tyrosine-protein phosphatase non-receptor type 11	IPI	14534538	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00053	T cell activation	P01303	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	10521483	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P02785	Valine biosynthesis	P03216	Acetolactate synthase	SULSO|EnsemblGenome=SSO0579|UniProtKB=Q7LXT8	Acetolactate synthase	ISS			PTHR18968:SF13	ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346875|UniProtKB=O08648	Mitogen-activated protein kinase kinase kinase 4	ISS			PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	NAS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	TAS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04397	p53 pathway by glucose deprivation	P04641	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	HALSA|EnsemblGenome=VNG_0896G|UniProtKB=Q9HR24	Cytidine aminohydrolase	ISS			PTHR11644:SF2	CYTIDINE DEAMINASE
P00012	Cadherin signaling pathway	P00470	F-actin	HUMAN|HGNC=129|UniProtKB=P68133	Actin, alpha skeletal muscle	IC	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DROME|FlyBase=FBgn0000046|UniProtKB=P10981	Actin-87E	ISS	14684598	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000015972|UniProtKB=H2QPB5	Protocadherin 7	ISS	8120095	PubMed	PTHR43912:SF8	PROTOCADHERIN-7
P00021	FGF signaling pathway	P00627	ERK1-2	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	PANTR|Ensembl=ENSPTRG00000010295|UniProtKB=H2QF07	Uncharacterized protein	ISS	608972	OMIM	PTHR22952:SF98	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 3
P00006	Apoptosis signaling pathway	P00318	PKCs	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00009	Axon guidance mediated by netrin	P00363	PI3K	DROME|FlyBase=FBgn0015278|UniProtKB=Q7K3H0	LD28067p	ISS	96278830	PubMed	PTHR10048:SF64	LD28067P
P00034	Integrin signalling pathway	P00907	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00036	Interleukin signaling pathway	P00965	ERK	MACMU|Ensembl=ENSMMUG00000001187|UniProtKB=F6R8N9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P04397	p53 pathway by glucose deprivation	P04641	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00364	cdc42	TAKRU|Ensembl=ENSTRUG00000008289|UniProtKB=H2T7U8	Uncharacterized protein	ISS	9658176	PubMed	PTHR24072:SF129	CDC42L PROTEIN
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	ORYSJ|EnsemblGenome=OS02G0148100|UniProtKB=Q6Z437	Mitogen-activated protein kinase 3	TAS			PTHR24055:SF216	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00048	PI3 kinase pathway	P01199	Galpha	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00059	p53 pathway	P04609	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04398	p53 pathway feedback loops 2	P04651	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P04395	Vasopressin synthesis	P04589	Signal Peptidase	MOUSE|MGI=MGI=1913536|UniProtKB=Q9D8V7	Signal peptidase complex catalytic subunit SEC11C	IC	2092035	PubMed	PTHR10806:SF12	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11C
P00050	Plasminogen activating cascade	P01246	Plasmin	MACMU|Gene=PLG|UniProtKB=P12545	Plasminogen	ISS	2318848	PubMed	PTHR24261:SF6	PLASMINOGEN
P00010	B cell activation	P00398	IP3R	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	IGI	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05913	Enkephalin release	G06045	preproenkephalin	HUMAN|HGNC=8831|UniProtKB=P01210	Proenkephalin-A	IC	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00059	p53 pathway	G01563	MDM-2	RAT|RGD=1309306|UniProtKB=Q5XIN1	Protein Mdm4	ISS			PTHR13844:SF20	PROTEIN MDM4
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00775	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00029	Huntington disease	P00771	Sin3A	YEAST|SGD=S000005364|UniProtKB=P22579	Transcriptional regulatory protein SIN3	IDA	10441327	PubMed	PTHR12346:SF0	SIN3A, ISOFORM G
P00006	Apoptosis signaling pathway	P00269	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00556	PLCgamma	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	MOUSE|MGI=MGI=95809|UniProtKB=P23819	Glutamate receptor 2	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P02786	Vitamin B6 biosynthesis	P03225	1-Deoxyxylulose-5-phosphate synthase	ARATH|TAIR=AT5G11380|UniProtKB=Q9LFL9	1-D-deoxyxylulose 5-phosphate synthase-like protein	ISS			PTHR43322:SF3	1-D-DEOXYXYLULOSE 5-PHOSPHATE SYNTHASE-LIKE PROTEIN
P00029	Huntington disease	G01535	PIG3	MOUSE|MGI=MGI=2142534|UniProtKB=Q80TB8	Synaptic vesicle membrane protein VAT-1 homolog-like	TAS	12932731	PubMed	PTHR44054:SF2	SYNAPTIC VESICLE MEMBRANE PROTEIN VAT-1 HOMOLOG-LIKE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00577	PI3K	XENTR|Xenbase=XB-GENE-6464721|UniProtKB=F6X5Q2	Uncharacterized protein	ISS			PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P02783	Tryptophan biosynthesis	P03211	Phosphribosyl anthranilate isomerase	DEIRA|EnsemblGenome=DR_0123|UniProtKB=Q9RY28	N-(5'-phosphoribosyl)anthranilate isomerase	ISS			PTHR42894:SF1	N- 5'-PHOSPHORIBOSYL ANTHRANILATE ISOMERASE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	IC	11554549	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00006	Apoptosis signaling pathway	P00310	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00927	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12912997	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00012	Cadherin signaling pathway	P00467	alpha-catenin	MACMU|Ensembl=ENSMMUG00000017985|UniProtKB=F7DN31	Uncharacterized protein	ISS	9362521	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00047	PDGF signaling pathway	P01174	Rho	MACMU|Ensembl=ENSMMUG00000022060|UniProtKB=F7HP48	Uncharacterized protein	ISS	8288572	PubMed	PTHR23181:SF4	RHO GTPASE-ACTIVATING PROTEIN 9
P02743	Formyltetrahydroformate biosynthesis	P02952	Methylene tetrahydrofolate dehydrogenase	AQUAE|EnsemblGenome=aq_1898|UniProtKB=O67736	Bifunctional protein FolD	ISS			PTHR10025:SF46	BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, MITOCHONDRIAL
P00009	Axon guidance mediated by netrin	P00361	Ena	RAT|RGD=1311542|UniProtKB=A0A0G2K9C0	Protein Vasp	ISS			PTHR11202:SF12	VASODILATOR-STIMULATED PHOSPHOPROTEIN
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	TAKRU|Ensembl=ENSTRUG00000016241|UniProtKB=H2UX35	Protein kinase C	ISS	11880265	PubMed	PTHR24356:SF305	PROTEIN KINASE C
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00969	Signaling subunit	CHICK|Ensembl=ENSGALG00000014716|UniProtKB=Q9W6U9	Glycoprotein 130	TAS	10210178	PubMed	PTHR23036:SF83	INTERLEUKIN-6 RECEPTOR SUBUNIT BETA
P00015	Circadian clock system	G01499	per	MACMU|Ensembl=ENSMMUG00000021798|UniProtKB=F7ESU2	Uncharacterized protein	ISS	12782655	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P05731	GABA-B receptor II signaling	P05752	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	STRCO|EnsemblGenome=CAA20173|UniProtKB=O86565	Serine hydroxymethyltransferase	ISS			PTHR11680:SF21	SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC
P00019	Endothelin signaling pathway	P00577	PI3K	CANAL|CGD=CAL0068551|UniProtKB=Q5AAR9	Phosphatidylinositol 3-kinase	IGI	10870104	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00047	PDGF signaling pathway	P01143	ERK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	RAT|RGD=2034|UniProtKB=P26770	Adenylate cyclase type 4	IDA	1946437	PubMed	PTHR11920:SF286	ADENYLATE CYCLASE TYPE 4
P00010	B cell activation	P00388	PLC gamma2	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	LEIMA|EnsemblGenome=LmjF.18.1080|UniProtKB=Q27687	Protein kinase A catalytic subunit	IC	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00005	Angiogenesis	P00219	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00010	B cell activation	P00375	Calmodulin	STRPU|EnsemblGenome=SPU_005033|UniProtKB=W4XNQ0	Uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF263	SUBFAMILY NOT NAMED
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	IC	15621031	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	3136397	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00018	EGF receptor signaling pathway	P00547	PP2A	BOVIN|Ensembl=ENSBTAG00000000754|UniProtKB=A2VDZ0	Protein phosphatase 2, regulatory subunit B', alpha isoform	ISS	10092233	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01438	PP2A	CANLF|Ensembl=ENSCAFG00000006453|UniProtKB=F6X958	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01211	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	HUMAN|HGNC=4572|UniProtKB=P42262	Glutamate receptor 2	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00010	B cell activation	P00371	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01439	C-terminal Binding Protein	BOVIN|Ensembl=ENSBTAG00000003397|UniProtKB=Q0VCQ1	C-terminal-binding protein 2	ISS	10375506	PubMed	PTHR10996:SF72	C-TERMINAL-BINDING PROTEIN 2
P00057	Wnt signaling pathway	P01428	Frizzled	RAT|RGD=631406|UniProtKB=Q8CHL0	Frizzled-5	ISS	8717036	PubMed	PTHR11309:SF126	FRIZZLED-5
P00019	Endothelin signaling pathway	P00572	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00018	EGF receptor signaling pathway	P00539	14-3-3	RAT|RGD=3978|UniProtKB=P68511	14-3-3 protein eta	ISS	10407019	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00050	Plasminogen activating cascade	P01258	Fibrin C-terminal truncation	RAT|RGD=2603|UniProtKB=P06399	Fibrinogen alpha chain	ISS	1706800	gi	PTHR19143:SF232	FIBRINOGEN ALPHA CHAIN
P00053	T cell activation	P01300	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	20384797	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	PANTR|Ensembl=ENSPTRG00000005093|UniProtKB=H2Q687	Uncharacterized protein	ISS	11114383	PubMed	PTHR15947:SF0	INTERLEUKIN-23 SUBUNIT ALPHA
P02726	Aminobutyrate degradation	P02824	Succinate semi-aldehyde dehydrogenase	ECOLI|EcoGene=EG13817|UniProtKB=P76149	Succinate semialdehyde dehydrogenase [NAD(P)+] Sad	ISS			PTHR43217:SF1	SUCCINATE SEMIALDEHYDE DEHYDROGENASE  NAD P +  SAD
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	PANTR|Ensembl=ENSPTRG00000002979|UniProtKB=H2Q2M8	Uncharacterized protein	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00048	PI3 kinase pathway	P01177	P110ACT	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02728	Arginine biosynthesis	P02848	N-acetylglutamate synthase	YEAST|SGD=S000003607|UniProtKB=P40360	Amino-acid acetyltransferase, mitochondrial	ISS			PTHR23342:SF4	AMINO-ACID ACETYLTRANSFERASE, MITOCHONDRIAL
P00034	Integrin signalling pathway	P00922	Collagen	MACMU|Ensembl=ENSMMUG00000003850|UniProtKB=F7HAB7	Uncharacterized protein	ISS	10778855	PubMed	PTHR24023:SF509	COLLAGEN ALPHA-2 XI  CHAIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	PANTR|Ensembl=ENSPTRG00000009552|UniProtKB=H2QDP8	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF170	REGULATOR OF G-PROTEIN SIGNALING 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS			PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00029	Huntington disease	P00796	Kainate receptor	HUMAN|HGNC=4583|UniProtKB=Q16478	Glutamate receptor ionotropic, kainate 5	IDA	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CANLF|Ensembl=ENSCAFG00000013148|UniProtKB=Q5R1P3	Glutamate receptor ionotropic, NMDA 2B	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00036	Interleukin signaling pathway	P00965	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IC	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MACMU|Ensembl=ENSMMUG00000009778|UniProtKB=F6Y1M7	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF385	MYOSIN-2
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P02728	Arginine biosynthesis	P02842	N-acetylornithine aminotransferase	SULSO|EnsemblGenome=SSO0160|UniProtKB=Q7SI94	Acetylornithine/acetyl-lysine aminotransferase	ISS	10074354	PubMed	PTHR11986:SF79	ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL
P00059	p53 pathway	P04622	Sin3	ORNAN|Ensembl=ENSOANG00000010605|UniProtKB=F7B0D4	Uncharacterized protein	ISS	10441327	PubMed	PTHR12346:SF2	PAIRED AMPHIPATHIC HELIX PROTEIN SIN3A
P00057	Wnt signaling pathway	P01444	Wnt	XENTR|Xenbase=XB-GENE-492636|UniProtKB=F7D1A1	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00056	VEGF signaling pathway	P01411	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000001114|UniProtKB=E1B7L9	Serine/threonine-protein kinase	ISS	12676944	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00053	T cell activation	P01324	rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CANLF|Ensembl=ENSCAFG00000005662|UniProtKB=E2R907	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00589	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	NAS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00550	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8235613	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	IDA	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00034	Integrin signalling pathway	P00920	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	IPI	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	LEIMA|EnsemblGenome=LmjF.23.0710|UniProtKB=Q9U0W1	Acetyl-coenzyme A synthetase	ISS			PTHR24095:SF14	ACETYL-COENZYME A SYNTHETASE 1
P00056	VEGF signaling pathway	P01408	Akt/PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00018	EGF receptor signaling pathway	P00551	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	IDA	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02759	Pyridoxal-5-phosphate biosynthesis	P03061	Pyridoxine-5-phosphate oxidase	MACMU|Ensembl=ENSMMUG00000003325|UniProtKB=F7EHD9	Pyridoxine-5'-phosphate oxidase	ISS	15182361	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DANRE|ZFIN=ZDB-GENE-040625-35|UniProtKB=Q6IQL9	Novel actin protein	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00004	Alzheimer disease-presenilin pathway	P00141	Membrane metalloprotease	MOUSE|MGI=MGI=1276107|UniProtKB=Q9WTR0	Matrix metalloproteinase-16	RCA			PTHR10201:SF26	MATRIX METALLOPROTEINASE-16
P02723	Adenine and hypoxanthine salvage pathway	P02805	Adenine phosphorylase	CAEEL|WormBase=WBGene00019298|UniProtKB=U4PSA1	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00053	T cell activation	P01305	Calmodulin	CANLF|Ensembl=ENSCAFG00000030049|UniProtKB=J9NWQ5	Uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF311	CALMODULIN
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04397	p53 pathway by glucose deprivation	P04639	AMPK	PANTR|Ensembl=ENSPTRG00000000788|UniProtKB=H2PZ45	Uncharacterized protein	ISS			PTHR24343:SF303	5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-2
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	RAT|RGD=1304749|UniProtKB=A0A0G2K0H3	Protein Lrp6	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MACMU|Ensembl=ENSMMUG00000019849|UniProtKB=F7GUV7	Bone morphogenetic protein 2	ISS	9759503	PubMed	PTHR11848:SF143	BONE MORPHOGENETIC PROTEIN 2
P00021	FGF signaling pathway	P00644	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04384	Gamma-aminobutyric acid synthesis	P04480	GABA aminotransferase	CAEEL|WormBase=WBGene00001794|UniProtKB=Q21217	Probable 4-aminobutyrate aminotransferase, mitochondrial	ISS	137150	OMIM	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00021	FGF signaling pathway	P00645	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05915	Opioid proenkephalin pathway	P05994	G-protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04397	p53 pathway by glucose deprivation	P04647	LKB1	PANTR|Ensembl=ENSPTRG00000010187|UniProtKB=H2QET9	Serine/threonine kinase 11	ISS	14985505	PubMed	PTHR44214:SF1	SERINE/THREONINE-PROTEIN KINASE STK11
P02740	De novo pyrimidine ribonucleotides biosythesis	P02926	Aspartate carbamoyltransferase	MYCTU|EnsemblGenome=Rv1380|UniProtKB=P9WIT7	Aspartate carbamoyltransferase	ISS			PTHR11405:SF16	ASPARTATE CARBAMOYLTRANSFERASE, CHLOROPLASTIC
P05915	Opioid proenkephalin pathway	P05994	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00056	VEGF signaling pathway	P01408	Akt/PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00260	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05913	Enkephalin release	P05972	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04393	Ras Pathway	P04563	Ets	BOVIN|Ensembl=ENSBTAG00000002341|UniProtKB=A5PJG9	ETS1 protein	ISS	3060801	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00018	EGF receptor signaling pathway	P00564	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12960248	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	CHICK|Ensembl=ENSGALG00000009403|UniProtKB=E1BQG4	Protein-serine/threonine kinase	RCA			PTHR24355:SF27	G PROTEIN-COUPLED RECEPTOR KINASE 5
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04393	Ras Pathway	P04553	PAK	XENTR|Xenbase=XB-GENE-961764|UniProtKB=F6W3Y0	Uncharacterized protein	ISS	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00375	Calmodulin	USTMA|Gene=UMAG_03910|UniProtKB=A0A0D1DU81	Chromosome 11, whole genome shotgun sequence	ISS			PTHR23050:SF245	AT16150P-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00059	p53 pathway	P04609	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06214	GBB signaling pathway	P06305	MAD	DROME|FlyBase=FBgn0011648|UniProtKB=P42003	Protein mothers against dpp	IGI	12736218	PubMed	PTHR13703:SF40	PROTEIN MOTHERS AGAINST DPP
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00006	Apoptosis signaling pathway	P00274	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00023	General transcription regulation	P00666	TFIIE	MOUSE|MGI=MGI=1921447|UniProtKB=Q9D0D5	General transcription factor IIE subunit 1	ISS	92065982	PubMed	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P04393	Ras Pathway	P04565	MKK4/7	MOUSE|MGI=MGI=1346869|UniProtKB=P47809	Dual specificity mitogen-activated protein kinase kinase 4	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00009	Axon guidance mediated by netrin	P00366	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	BOVIN|Ensembl=ENSBTAG00000040439|UniProtKB=F6Q2H9	Uncharacterized protein	ISS	12441358	PubMed	PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00398	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IGI	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02738	De novo purine biosynthesis	P02902	ADP reductase	HALSA|EnsemblGenome=VNG_2384G|UniProtKB=Q9HMU3	Ribonucleoside reductase large chain	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00036	Interleukin signaling pathway	P00973	PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00310	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00778	NMDA receptor	CANLF|Ensembl=ENSCAFG00000002617|UniProtKB=E2QUL1	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	MACMU|Ensembl=ENSMMUG00000008351|UniProtKB=F7HRV5	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00036	Interleukin signaling pathway	P00970	Interleukin	MACMU|Ensembl=ENSMMUG00000001655|UniProtKB=F7G6Q1	Interleukin-7	IC			PTHR45542:SF1	INTERLEUKIN-7
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IDA	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CHICK|Gene=SKI|UniProtKB=P49140	Ski oncogene	IGI	10485843	PubMed	PTHR10005:SF15	SKI ONCOGENE
P04393	Ras Pathway	P04569	Cdc42	TAKRU|Ensembl=ENSTRUG00000008289|UniProtKB=H2T7U8	Uncharacterized protein	ISS	9658176	PubMed	PTHR24072:SF129	CDC42L PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	HUMAN|HGNC=4598|UniProtKB=O15303	Metabotropic glutamate receptor 6	IDA			PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00630	RKIP	DROME|FlyBase=FBgn0038972|UniProtKB=Q9VD02	CG7054	ISS			PTHR11362:SF28	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P00029	Huntington disease	P00777	CBP	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	IDA	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00048	PI3 kinase pathway	P01202	p85	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	SCHMA|EnsemblGenome=Smp_161920|UniProtKB=G4VSW5	Putative actin	IC	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	MACMU|Ensembl=ENSMMUG00000009341|UniProtKB=F6UA54	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	IC	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00010	B cell activation	P00402	Jnk	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	8170357	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00019	Endothelin signaling pathway	P00566	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00047	PDGF signaling pathway	P01163	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00059	p53 pathway	P01481	ATM/ATR	MOUSE|MGI=MGI=108028|UniProtKB=Q9JKK8	Serine/threonine-protein kinase ATR	ISS	10196661	PubMed	PTHR11139:SF69	SERINE/THREONINE-PROTEIN KINASE ATR
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00057	Wnt signaling pathway	P01443	Phospholipase C	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	IDA	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P02749	Leucine biosynthesis	P03000	Branched chain amino acid aminotransferase	NEUCR|Gene=NCU04292|UniProtKB=Q1K779	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF69	SUBFAMILY NOT NAMED
P06959	CCKR signaling map	G07262	HDC	HUMAN|HGNC=4855|UniProtKB=P19113	Histidine decarboxylase	RCA	14670968	PubMed	PTHR11999:SF68	HISTIDINE DECARBOXYLASE
P00048	PI3 kinase pathway	P01189	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00057	Wnt signaling pathway	P01435	SWI/SNF	ANOGA|EnsemblGenome=AGAP001154|UniProtKB=Q7PUT1	AGAP001154-PA	ISS	11532957	PubMed	PTHR10019:SF5	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY B MEMBER 1
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01185	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00029	Huntington disease	P00781	Dynactin	DROME|FlyBase=FBgn0001108|UniProtKB=P13496	Dynactin subunit 1	IPI	9454836	PubMed	PTHR18916:SF6	DYNACTIN SUBUNIT 1
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00024	Glycolysis	P00676	Glyceraldehyde 3-phosphate dehydrogenase	STRCO|Gene=CAC01538|UniProtKB=Q9FC43	Glyceraldehyde-3-phosphate dehydrogenase	ISS	21225323	gi	PTHR43454:SF1	SUBFAMILY NOT NAMED
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MOUSE|MGI=MGI=95823|UniProtKB=Q03391	Glutamate receptor ionotropic, NMDA 2D	IC	14698601	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DANRE|ZFIN=ZDB-GENE-030131-6503|UniProtKB=Q7ZUC5	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF297	PROTEIN KINASE C DELTA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00006	Apoptosis signaling pathway	P00269	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CAEEL|WormBase=WBGene00000064|UniProtKB=P10984	Actin-2	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00018	EGF receptor signaling pathway	P00543	ERK1-2	ORYSJ|EnsemblGenome=OS02G0148100|UniProtKB=Q6Z437	Mitogen-activated protein kinase 3	ISS			PTHR24055:SF216	SUBFAMILY NOT NAMED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00642	MEK1-2	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P02772	Pyruvate metabolism	P03141	Citrate Synthetase	ECOLI|EcoGene=EG10402|UniProtKB=P0ABH7	Citrate synthase	ISS	15829999	gi	PTHR42871:SF1	CITRATE SYNTHASE
P00057	Wnt signaling pathway	P01428	Frizzled	PANTR|Ensembl=ENSPTRG00000028542|UniProtKB=H2R591	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF79	FRIZZLED-9
P00048	PI3 kinase pathway	P01177	P110ACT	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	RAT|RGD=628837|UniProtKB=P60711	Actin, cytoplasmic 1	IC	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00057	Wnt signaling pathway	P01443	Phospholipase C	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00019	Endothelin signaling pathway	P00568	PKC	TAKRU|Ensembl=ENSTRUG00000016241|UniProtKB=H2UX35	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF305	PROTEIN KINASE C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	12972619	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00030	Hypoxia response via HIF activation	P00824	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	TAKRU|Ensembl=ENSTRUG00000016101|UniProtKB=H2UW32	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	MACMU|Ensembl=ENSMMUG00000009885|UniProtKB=F6YL51	Uncharacterized protein	ISS	11907044	PubMed	PTHR44025:SF7	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00877	MLCK	PANTR|Ensembl=ENSPTRG00000015307|UniProtKB=H2R459	Uncharacterized protein	ISS	600922	OMIM	PTHR45480:SF1	MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04547	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CANLF|Ensembl=ENSCAFG00000010787|UniProtKB=E2R3W6	Uncharacterized protein	ISS	2039532	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00018	EGF receptor signaling pathway	P00564	Rac	ORYSJ|EnsemblGenome=OS02G0312600|UniProtKB=Q6Z7L8	Rac-like GTP-binding protein 7	ISS			PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P02770	Pyridoxal phosphate salvage pathway	P03123	Pyridoxine-5-phosphate oxidase	PANTR|Ensembl=ENSPTRG00000009343|UniProtKB=H2QDB2	Pyridoxamine 5'-phosphate oxidase	ISS	9601034	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BOVIN|Ensembl=ENSBTAG00000005570|UniProtKB=E1BKL2	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P00006	Apoptosis signaling pathway	P00313	IKK	HUMAN|HGNC=5960|UniProtKB=O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DROME|FlyBase=FBgn0259680|UniProtKB=P83099	Putative protein kinase C delta type homolog	ISS	2837282	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DANRE|ZFIN=ZDB-GENE-030131-6503|UniProtKB=Q7ZUC5	Protein kinase C delta type	ISS	11880265	PubMed	PTHR24356:SF297	PROTEIN KINASE C DELTA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04398	p53 pathway feedback loops 2	P04651	Ras	XENTR|Xenbase=XB-GENE-494548|UniProtKB=F7EC26	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00047	PDGF signaling pathway	P01151	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IDA	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00059	p53 pathway	P04623	CBP	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00010	B cell activation	P00401	jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00006	Apoptosis signaling pathway	P00269	MAPK	YEAST|SGD=S000003272|UniProtKB=P14681	Mitogen-activated protein kinase KSS1	ISS	11707292	PubMed	PTHR24055:SF338	MITOGEN-ACTIVATED PROTEIN KINASE KSS1
P00011	Blood coagulation	P00411	PAI-1	PANTR|Ensembl=ENSPTRG00000019519|UniProtKB=H2QV47	Uncharacterized protein	ISS	189578	gi	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00005	Angiogenesis	P00181	SHP2	MOUSE|MGI=MGI=99511|UniProtKB=P35235	Tyrosine-protein phosphatase non-receptor type 11	ISS	14525967	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00057	Wnt signaling pathway	P01455	Smad4	BOVIN|Ensembl=ENSBTAG00000021772|UniProtKB=F1MD43	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF36	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00029	Huntington disease	P00805	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00054	Toll receptor signaling pathway	P01348	A20	CANLF|Ensembl=ENSCAFG00000000267|UniProtKB=E2QYU8	Uncharacterized protein	ISS			PTHR13367:SF3	TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 3
P00012	Cadherin signaling pathway	P00471	Cadherin	CANLF|Ensembl=ENSCAFG00000014229|UniProtKB=F1P8X5	Uncharacterized protein	ISS	8120095	PubMed	PTHR43956:SF3	CADHERIN-23
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	XENTR|Xenbase=XB-GENE-484003|UniProtKB=Q6P365	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P05913	Enkephalin release	P05972	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g242065|UniProtKB=A7S0V7	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00047	PDGF signaling pathway	P01175	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	7680960	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P04395	Vasopressin synthesis	P04594	Neurophysin	MACMU|Ensembl=ENSMMUG00000010678|UniProtKB=F7AXI7	Uncharacterized protein	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00046	Oxidative stress response	P01135	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P02738	De novo purine biosynthesis	P02891	GDP kinase	HUMAN|HGNC=7849|UniProtKB=P15531	Nucleoside diphosphate kinase A	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P00057	Wnt signaling pathway	P01471	alpha-catenin	RAT|RGD=1359485|UniProtKB=Q5U302	Catenin (Cadherin associated protein), alpha 1	ISS	9362521	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P02727	Androgen/estrogene/progesterone biosynthesis	P02833	3beta-Hydroxysteroid dehydrogenase	MOUSE|MGI=MGI=96235|UniProtKB=P26150	3 beta-hydroxysteroid dehydrogenase/Delta 5--4-isomerase type 3	IPI	1924345	PubMed	PTHR10366:SF364	3 BETA-HYDROXYSTEROID DEHYDROGENASE/DELTA 5--4-ISOMERASE TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CHICK|Ensembl=ENSGALG00000014620|UniProtKB=F1N8P3	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00010	B cell activation	P00400	Btk	MONDO|Ensembl=ENSMODG00000011651|UniProtKB=F6YES1	Tyrosine-protein kinase	ISS	10521450	PubMed	PTHR24418:SF92	TYROSINE-PROTEIN KINASE BTK
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	CRYNJ|EnsemblGenome=CND03830|UniProtKB=Q5KI86	Uncharacterized protein	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00029	Huntington disease	P00774	Dynein complex	MOUSE|MGI=MGI=1861457|UniProtKB=P63168	Dynein light chain 1, cytoplasmic	ISS	9454836	PubMed	PTHR11886:SF52	DYNEIN LIGHT CHAIN 1, CYTOPLASMIC
P00025	Hedgehog signaling pathway	P00682	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	IXOSC|EnsemblGenome=ISCW014549|UniProtKB=B7QGY5	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00548	RKIP	ANOGA|EnsemblGenome=AGAP013036|UniProtKB=F5HM76	AGAP013036-PA	ISS			PTHR11362:SF28	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P00034	Integrin signalling pathway	P00951	Jnk	DROME|FlyBase=FBgn0024326|UniProtKB=O61444	MAP kinase kinase 4, isoform A	IDA			PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DAPPU|EnsemblGenome=DAPPUDRAFT_188187|UniProtKB=E9GJ31	Guanine nucleotide binding protein, q polypeptide	ISS	8457205	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00057	Wnt signaling pathway	P01465	Ggamma	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	RAT|RGD=2062|UniProtKB=P26817	Beta-adrenergic receptor kinase 1	RCA			PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P00034	Integrin signalling pathway	P00912	Arp2/3	MACMU|Ensembl=ENSMMUG00000019342|UniProtKB=F6PVY4	Uncharacterized protein	ISS	12932731	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00013	Cell cycle	P00480	Proteasome	BOVIN|Ensembl=ENSBTAG00000006101|UniProtKB=Q58DA0	26S proteasome non-ATPase regulatory subunit 4	ISS	13645506	gi	PTHR10223:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	XENTR|Ensembl=ENSXETG00000030140|UniProtKB=F7EP58	Uncharacterized protein (Fragment)	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	CAEEL|WormBase=WBGene00018569|UniProtKB=Q7JP68	cAMP-dependent protein kinase, catalytic subunit-like	ISS	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00047	PDGF signaling pathway	P01174	Rho	HUMAN|HGNC=677|UniProtKB=P85298	Rho GTPase-activating protein 8	ISS			PTHR23176:SF3	PROTEIN PRR5-ARHGAP8-RELATED
P00005	Angiogenesis	P00238	Ras	MONDO|Ensembl=ENSMODG00000025248|UniProtKB=F7F5X1	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MACMU|Ensembl=ENSMMUG00000032424|UniProtKB=F6UC75	Uncharacterized protein	ISS	6753458	gi	PTHR10489:SF671	C-X-C CHEMOKINE RECEPTOR TYPE 3
P00018	EGF receptor signaling pathway	P00551	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DANRE|ZFIN=ZDB-GENE-050417-59|UniProtKB=Q15KE4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00006	Apoptosis signaling pathway	P00278	Bag	MOUSE|MGI=MGI=1352493|UniProtKB=Q9JLV1	BAG family molecular chaperone regulator 3	ISS			PTHR12329:SF12	BAG FAMILY MOLECULAR CHAPERONE REGULATOR 3
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT1G07880|UniProtKB=Q9LQQ9	Mitogen-activated protein kinase 13	IDA	11707292	PubMed	PTHR24055:SF185	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04398	p53 pathway feedback loops 2	G04714	PTEN	CAEEL|WormBase=WBGene00000913|UniProtKB=G5EE01	DAF-18	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00047	PDGF signaling pathway	P01143	ERK	RAT|RGD=62087|UniProtKB=P27704	Mitogen-activated protein kinase 6	ISS	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	HUMAN|HGNC=3026|UniProtKB=P21918	D(1B) dopamine receptor	ISS	11248120	PubMed	PTHR43893:SF8	D 1B  DOPAMINE RECEPTOR
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00054	Toll receptor signaling pathway	P01355	AP1	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00047	PDGF signaling pathway	P01151	PKB	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00551	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	10514528	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	9514948	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P04397	p53 pathway by glucose deprivation	P04641	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00737	Rap1GAP	PANTR|Ensembl=ENSPTRG00000021385|UniProtKB=H2QXX1	Uncharacterized protein	ISS	10419452	PubMed	PTHR15711:SF31	GTPASE-ACTIVATING RAP/RAN-GAP DOMAIN-LIKE PROTEIN 3
P00047	PDGF signaling pathway	P01160	IP3 receptor	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	TAS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00005	Angiogenesis	P00194	Paxillin	RAT|RGD=1305759|UniProtKB=Q66H76	Paxillin	ISS	7579684	PubMed	PTHR24216:SF11	PAXILLIN
P00005	Angiogenesis	P00238	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	ORNAN|Ensembl=ENSOANG00000007391|UniProtKB=F6PQH1	Uncharacterized protein	ISS	94365697	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MOUSE|MGI=MGI=95814|UniProtKB=Q60934	Glutamate receptor ionotropic, kainate 1	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00206	Wnt	MOUSE|MGI=MGI=98959|UniProtKB=P22726	Protein Wnt-5b	ISS	8717036	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	88318957	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06732	ATF2	MOUSE|MGI=MGI=109349|UniProtKB=P16951	Cyclic AMP-dependent transcription factor ATF-2	RCA	10207617	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00005	Angiogenesis	P00223	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00561	STAT	DANRE|ZFIN=ZDB-GENE-030820-2|UniProtKB=Q68SP3	Signal transducer and activator of transcription	ISS			PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CHICK|Gene=MYH11|UniProtKB=P10587	Myosin-11	IC	89264452	PubMed	PTHR13140:SF335	MYOSIN-11
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IGI	91298951	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00925	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00056	VEGF signaling pathway	P01415	MAPKAPK2/3	BOVIN|Ensembl=ENSBTAG00000038107|UniProtKB=F1MCX5	Uncharacterized protein	ISS	7923354	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00034	Integrin signalling pathway	P00924	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IPI	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00318	PKCs	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04396	Vitamin D metabolism and pathway	P04604	FdxR	RAT|RGD=621648|UniProtKB=P56522	NADPH:adrenodoxin oxidoreductase, mitochondrial	TAS	2845396	PubMed	PTHR11938:SF91	NADPH:ADRENODOXIN OXIDOREDUCTASE, MITOCHONDRIAL
P00005	Angiogenesis	P00223	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00780	Microtubule	HUMAN|HGNC=20772|UniProtKB=Q13509	Tubulin beta-3 chain	IDA	9454836	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	4506785	gi	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	CANAL|CGD=CAL0005264|UniProtKB=Q5ACW5	Casein kinase II subunit beta	IDA	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00049	Parkinson disease	P01211	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02738	De novo purine biosynthesis	P02902	ADP reductase	PLAF7|EnsemblGenome=PF14_0053|UniProtKB=Q8IM38	Ribonucleotide reductase small subunit	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05918	p38 MAPK pathway	P06035	TAB1	PANTR|Ensembl=ENSPTRG00000014395|UniProtKB=H2QLQ4	Uncharacterized protein	ISS	8638164	PubMed	PTHR13832:SF533	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1
P00029	Huntington disease	P00780	Microtubule	PHANO|Gene=SNOG_06790|UniProtKB=P41799	Tubulin beta chain	IDA	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00034	Integrin signalling pathway	P00927	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00012	Cadherin signaling pathway	P00474	Wnt	CANLF|Ensembl=ENSCAFG00000009672|UniProtKB=E2RDT2	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00012	Cadherin signaling pathway	P00466	EGFR	CHICK|Ensembl=ENSGALG00000003126|UniProtKB=F1P258	Receptor protein-tyrosine kinase	ISS	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00003	Alzheimer disease-amyloid secretase pathway	P00079	alpha7 nicotinic acetylcholine receptor	MACMU|Ensembl=ENSMMUG00000022577|UniProtKB=Q866A2	Neuronal acetylcholine receptor subunit alpha-7	ISS	85270494	PubMed	PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P00006	Apoptosis signaling pathway	P00297	NFkappaB	RAT|RGD=1307189|UniProtKB=Q5U2Z4	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	ISS	12574369	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	ECOLI|EcoGene=EG10810|UniProtKB=P0A7E5	CTP synthase	ISS			PTHR11550:SF0	CTP SYNTHASE
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	DROME|FlyBase=FBgn0019947|UniProtKB=O02194	Presenilin homolog	IDA	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00049	Parkinson disease	P01211	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00006	Apoptosis signaling pathway	P00309	Smac/Diablo	DROME|FlyBase=FBgn0040230|UniProtKB=Q9VUU5	Kelch-like protein diablo	ISS			PTHR24412:SF212	KELCH-LIKE PROTEIN 20
P02747	Histidine biosynthesis	P02992	Imidazol glycerol phosphate synthase	BACTN|EnsemblGenome=BT_1380|UniProtKB=Q8A7Z4	Imidazole glycerol phosphate synthase subunit HisH	ISS			PTHR42701:SF1	IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISH
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	13620175	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	HUMAN|HGNC=12333|UniProtKB=P48995	Short transient receptor potential channel 1	IDA	11055438	PubMed	PTHR10117:SF56	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 1
P04393	Ras Pathway	P04569	Cdc42	HUMAN|HGNC=1736|UniProtKB=P60953	Cell division control protein 42 homolog	IDA	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00010	B cell activation	P00386	Calcineurin	MOUSE|MGI=MGI=107162|UniProtKB=P48455	Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform	IDA	12091710	PubMed	PTHR11668:SF186	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT GAMMA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	ANOGA|EnsemblGenome=AGAP001478|UniProtKB=Q7PXM3	AGAP001478-PA	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05916	Opioid prodynorphin pathway	P06002	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00047	PDGF signaling pathway	P01149	MNK1/2	MACMU|Ensembl=ENSMMUG00000011265|UniProtKB=F6WP09	Uncharacterized protein	ISS	9155017	PubMed	PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P00021	FGF signaling pathway	P00634	MEKK1-5	MOUSE|MGI=MGI=1346875|UniProtKB=O08648	Mitogen-activated protein kinase kinase kinase 4	IGI	602425	OMIM	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00048	PI3 kinase pathway	P01181	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IPI	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00036	Interleukin signaling pathway	P00983	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00006	Apoptosis signaling pathway	P00302	ATF	XENTR|Xenbase=XB-GENE-945015|UniProtKB=F6QA46	Uncharacterized protein	ISS	1354612	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000003300|UniProtKB=H2Q326	Uncharacterized protein	ISS	8120095	PubMed	PTHR43956:SF6	PROTOCADHERIN-16
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	CANLF|Gene=HTR1D|UniProtKB=P11614	5-hydroxytryptamine receptor 1D	ISS	12441358	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00020	FAS signaling pathway	P00620	CytochromeC	ORYSJ|EnsemblGenome=OS05G0301700|UniProtKB=Q0DJC3	Os05g0301700 protein	IGI	9027315	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00004	Alzheimer disease-presenilin pathway	P00128	Erb-B4	MONDO|Ensembl=ENSMODG00000015755|UniProtKB=F6ZSZ9	Uncharacterized protein (Fragment)	ISS	4884676	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00057	Wnt signaling pathway	P01439	C-terminal Binding Protein	DANRE|ZFIN=ZDB-GENE-060421-4235|UniProtKB=Q1RLQ4	Uncharacterized protein	ISS	10375506	PubMed	PTHR10996:SF128	C-TERMINAL-BINDING PROTEIN 1
P00041	Metabotropic glutamate receptor group I pathway	P01062	mGluR1	PANTR|Ensembl=ENSPTRG00000018684|UniProtKB=C7G3M7	Glutamate receptor, metabotropic 1	ISS	14614461	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00005	Angiogenesis	P00254	GTPase	CHICK|Ensembl=ENSGALG00000016485|UniProtKB=O93468	GTP-binding protein	ISS	11973360	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00057	Wnt signaling pathway	P01446	Calcineurin	BOVIN|Ensembl=ENSBTAG00000020133|UniProtKB=A5D7T5	Serine/threonine-protein phosphatase	ISS	12015605	PubMed	PTHR11668:SF186	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT GAMMA ISOFORM
P00021	FGF signaling pathway	P00629	PP2A	DANRE|ZFIN=ZDB-GENE-040426-2487|UniProtKB=Q803G3	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=1310236|UniProtKB=D4A229	Serine/threonine-protein kinase	ISS	12676944	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	ORNAN|Ensembl=ENSOANG00000013961|UniProtKB=F6VPY1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00047	PDGF signaling pathway	P01172	c-Myc	DANRE|ZFIN=ZDB-GENE-990415-162|UniProtKB=P52160	Transcriptional regulator Myc-A	ISS	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00019	Endothelin signaling pathway	P00572	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	ISS	10851062	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00021	FGF signaling pathway	P00648	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00049	Parkinson disease	P01211	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00912	Arp2/3	MACMU|Ensembl=ENSMMUG00000022808|UniProtKB=F6UWC3	Actin-related protein 2/3 complex subunit 2	ISS	17943202	gi	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	RCA	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00981	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00048	PI3 kinase pathway	G01544	GADD45	MONDO|Ensembl=ENSMODG00000000788|UniProtKB=F6SSE6	Uncharacterized protein	ISS	10097101	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01423	p38MAPK	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	HUMAN|HGNC=784|UniProtKB=P15336	Cyclic AMP-dependent transcription factor ATF-2	TAS	7875593	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00047	PDGF signaling pathway	P01151	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	10704417	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00005	Angiogenesis	P00212	EphR	PANTR|Ensembl=ENSPTRG00000015127|UniProtKB=H2QMY7	Uncharacterized protein	ISS			PTHR24416:SF18	EPHRIN TYPE-A RECEPTOR 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	RCA	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	BOVIN|Ensembl=ENSBTAG00000000219|UniProtKB=F1MCL3	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00046	Oxidative stress response	P01135	p38	DROME|FlyBase=FBgn0015765|UniProtKB=O62618	Mitogen-activated protein kinase 14A	TAS	9417090	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05918	p38 MAPK pathway	P06023	MEF	CANLF|Ensembl=ENSCAFG00000010775|UniProtKB=F6XZU9	Uncharacterized protein	ISS	11274345	PubMed	PTHR11945:SF256	MYOCYTE-SPECIFIC ENHANCER FACTOR 2A
P00036	Interleukin signaling pathway	P00997	Shc	MOUSE|MGI=MGI=98296|UniProtKB=P98083	SHC-transforming protein 1	IGI	95096035	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00010	B cell activation	P00391	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00924	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00384	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	ISS	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00029	Huntington disease	P00778	NMDA receptor	HUMAN|HGNC=4586|UniProtKB=Q13224	Glutamate receptor ionotropic, NMDA 2B	IDA	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DANRE|ZFIN=ZDB-GENE-050417-267|UniProtKB=F1QUN8	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF263	ACTIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04393	Ras Pathway	P04559	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P02743	Formyltetrahydroformate biosynthesis	P02953	Cobalamin dependent homocysteine transmethylase	ECOLI|EcoGene=EG10587|UniProtKB=P13009	Methionine synthase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P00048	PI3 kinase pathway	P01177	P110ACT	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04375	5HT3 type receptor mediated signaling pathway	P04425	K+ channel	MACMU|Ensembl=ENSMMUG00000005826|UniProtKB=F6VE51	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00010	B cell activation	P00376	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	87226391	PubMed	PTHR24070:SF385	GTPASE HRAS
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	HUMAN|HGNC=4597|UniProtKB=P41594	Metabotropic glutamate receptor 5	IDA	9407094	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	HUMAN|HGNC=1954|UniProtKB=P08912	Muscarinic acetylcholine receptor M5	IDA	12181435	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00009	Axon guidance mediated by netrin	P00363	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01435	SWI/SNF	ARATH|TAIR=AT5G66750|UniProtKB=Q9XFH4	ATP-dependent DNA helicase DDM1	IDA	11532957	PubMed	PTHR10799:SF923	ATP-DEPENDENT DNA HELICASE DDM1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05915	Opioid proenkephalin pathway	P05994	G-protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00053	T cell activation	P01311	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00025	Hedgehog signaling pathway	P00691	CBP	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00034	Integrin signalling pathway	P00948	Rho	RAT|RGD=1304965|UniProtKB=A0A0G2K6E0	Protein Rhoc	ISS	12090470	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	TAS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	20384797	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	ISS	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00057	Wnt signaling pathway	P01448	CBP	ARATH|TAIR=AT1G55970|UniProtKB=Q9LG11	Histone acetyltransferase HAC4	IDA	10664585	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00004	Alzheimer disease-presenilin pathway	P00114	actin	HUMAN|HGNC=130|UniProtKB=P62736	Actin, aortic smooth muscle	IDA	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00047	PDGF signaling pathway	P01160	IP3 receptor	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	CANLF|Ensembl=ENSCAFG00000014931|UniProtKB=E2RCC0	Uncharacterized protein	ISS			PTHR15938:SF0	HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG
P00019	Endothelin signaling pathway	P00573	signal peptidase	MACMU|Ensembl=ENSMMUG00000011486|UniProtKB=F7D839	Signal peptidase complex catalytic subunit SEC11	ISS	2674115	PubMed	PTHR10806:SF8	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11A-RELATED
P00005	Angiogenesis	P00220	c-Jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00057	Wnt signaling pathway	P01472	Histone deacetylase	ARATH|TAIR=AT5G63110|UniProtKB=Q9FML2	Histone deacetylase 6	IDA	10485845	PubMed	PTHR10625:SF144	HISTONE DEACETYLASE 6-RELATED
P00018	EGF receptor signaling pathway	P00564	Rac	DICDI|dictyBase=DDB_G0279605|UniProtKB=P34148	Rho-related protein racB	IGI	94124042	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	DROME|FlyBase=FBgn0019947|UniProtKB=O02194	Presenilin homolog	TAS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P02729	Ascorbate degradation	P02852	L-xylulose-5-phosphate-3-epimerase	THEMA|EnsemblGenome=TM_1718|UniProtKB=Q9X243	Ribulose-phosphate 3-epimerase	ISS			PTHR11749:SF3	RIBULOSE-PHOSPHATE 3-EPIMERASE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00009	Axon guidance mediated by netrin	P00366	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00010	B cell activation	P00383	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00052	TGF-beta signaling pathway	P01288	FKBP12	HUMAN|HGNC=3712|UniProtKB=P68106	Peptidyl-prolyl cis-trans isomerase FKBP1B	ISS			PTHR10516:SF309	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1B
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P02738	De novo purine biosynthesis	P02909	GDP reductase	YEAST|SGD=S000001328|UniProtKB=P21672	Ribonucleoside-diphosphate reductase large chain 2	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P04393	Ras Pathway	P04567	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	10514528	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00047	PDGF signaling pathway	P01162	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00019	Endothelin signaling pathway	P00568	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00547	PP2A	TAKRU|Ensembl=ENSTRUG00000003840|UniProtKB=H2S9H8	Uncharacterized protein	ISS	11007767	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00038	JAK/STAT signaling pathway	P01031	PIAS	ORNAN|Ensembl=ENSOANG00000012017|UniProtKB=F7DX37	Uncharacterized protein	ISS	8682149	PubMed	PTHR10782:SF12	E3 SUMO-PROTEIN LIGASE PIAS2
P00001	Adrenaline and noradrenaline biosynthesis	P00068	amine translocator	HUMAN|HGNC=27960|UniProtKB=Q695T7	Sodium-dependent neutral amino acid transporter B(0)AT1	IC	12719981	PubMed	PTHR11616:SF125	SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER B 0 AT1
P00006	Apoptosis signaling pathway	P00318	PKCs	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05731	GABA-B receptor II signaling	P05754	Ggamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00057	Wnt signaling pathway	P01444	Wnt	CIOIN|Ensembl=ENSCING00000000407|UniProtKB=Q9U6V0	Protein Wnt	IDA	8717036	PubMed	PTHR12027:SF77	PROTEIN WNT-5
P00059	p53 pathway	P04633	P110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	MOUSE|MGI=MGI=1351342|UniProtKB=Q3UVX5	Metabotropic glutamate receptor 5	ISS	12351712	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00029	Huntington disease	P00807	Actin	MOUSE|MGI=MGI=104589|UniProtKB=P63268	Actin, gamma-enteric smooth muscle	IDA	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P02723	Adenine and hypoxanthine salvage pathway	P02810	Adenine phosphoribosyl transferase	SCHPO|PomBase=SPAC23A1.03|UniProtKB=O42842	Adenine phosphoribosyltransferase	ISS			PTHR32315:SF3	ADENINE PHOSPHORIBOSYLTRANSFERASE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	9860142	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04585	TRH	MONDO|Ensembl=ENSMODG00000018321|UniProtKB=Q6YNX4	Glycoprotein hormones alpha chain	ISS			PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P04393	Ras Pathway	P04570	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00927	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00012	Cadherin signaling pathway	P00474	Wnt	MACMU|Ensembl=ENSMMUG00000021725|UniProtKB=F7E738	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00015	Circadian clock system	P00502	Casein kinase I	PANTR|Ensembl=ENSPTRG00000014365|UniProtKB=H2R0C8	Casein kinase 1, epsilon	ISS	11865049	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00053	T cell activation	P01311	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	15313841	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000009835|UniProtKB=F1MR37	Uncharacterized protein	ISS	14526084	PubMed	PTHR10037:SF137	VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1G
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	IC	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01161	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00034	Integrin signalling pathway	P00936	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	MACMU|Ensembl=ENSMMUG00000023041|UniProtKB=F6VEJ6	Uncharacterized protein	ISS	600075	OMIM	PTHR10126:SF34	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 2
P00029	Huntington disease	P00807	Actin	DANRE|ZFIN=ZDB-GENE-000322-1|UniProtKB=Q9I8V1	Actin, alpha 1, skeletal muscle	IDA	11889126	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	STRPU|EnsemblGenome=SPU_012282|UniProtKB=W4Y969	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF369	ACTIN-42A
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8683|UniProtKB=Q9Y5F1	Protocadherin beta-12	IDA	8120095	PubMed	PTHR24028:SF228	PROTOCADHERIN BETA-12
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	CAEEL|WormBase=WBGene00012968|UniProtKB=Q9XXD0	Uncharacterized protein	ISS			PTHR44192:SF2	SUBFAMILY NOT NAMED
P05913	Enkephalin release	P05972	PKA	LEIMA|EnsemblGenome=LmjF.35.3960|UniProtKB=E9AFM1	Protein kinase A catalytic subunit isoform 2	ISS	10218114	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00243	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00798	Clathrin	MOUSE|MGI=MGI=894297|UniProtKB=O08585	Clathrin light chain A	ISS	9388255	PubMed	PTHR10639:SF1	CLATHRIN LIGHT CHAIN A
P00005	Angiogenesis	P00255	Notch	MACMU|Ensembl=ENSMMUG00000017022|UniProtKB=F7HQZ9	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00006	Apoptosis signaling pathway	P00318	PKCs	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00029	Huntington disease	P00790	beta-Tubulin	RAT|RGD=1588452|UniProtKB=P85108	Tubulin beta-2A chain	TAS	12932731	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00045	Notch signaling pathway	P01101	Su(H)	MOUSE|MGI=MGI=96522|UniProtKB=P31266	Recombining binding protein suppressor of hairless	IDA	15187023	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00049	Parkinson disease	P01211	ERK	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	IDA	9836510	gi	PTHR24055:SF330	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000005917|UniProtKB=F6QM53	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT1G10210|UniProtKB=Q39021	Mitogen-activated protein kinase 1	ISS	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00057	Wnt signaling pathway	P01451	Galpha	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	TAS	14526383	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	XENTR|Xenbase=XB-GENE-6053489|UniProtKB=F6S8L5	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	TAS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00057	Wnt signaling pathway	P01465	Ggamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02753	Methionine biosynthesis	P03024	Homocysteine transmethylase	ARATH|TAIR=AT3G25900|UniProtKB=Q9SDL7	Homocysteine S-methyltransferase 1	ISS			PTHR21091:SF140	HOMOCYSTEINE S-METHYLTRANSFERASE 1
P04393	Ras Pathway	P04559	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	12676940	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DANRE|ZFIN=ZDB-GENE-040718-93|UniProtKB=Q6DGZ5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00006	Apoptosis signaling pathway	P00274	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00004	Alzheimer disease-presenilin pathway	P00167	CD44 transmembrane fragment	CHICK|Ensembl=ENSGALG00000007849|UniProtKB=F1NL98	Uncharacterized protein	IDA	14871815	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00047	PDGF signaling pathway	P01159	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P02788	Xanthine and guanine salvage pathway	P03249	Guanine deaminase	PSEAE|EnsemblGenome=PA0134|UniProtKB=Q9I6Z8	Probable guanine deaminase	ISS	10984043	PubMed	PTHR11271:SF6	GUANINE DEAMINASE
P00018	EGF receptor signaling pathway	P00560	Raf-1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IGI	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02736	Coenzyme A biosynthesis	P02883	Pantothenoylcysteine decarboxylase	AQUAE|EnsemblGenome=aq_815|UniProtKB=O66997	Pantothenate metabolism flavoprotein	ISS			PTHR14359:SF6	PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE
P00048	PI3 kinase pathway	P01196	PDK1	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00049	Parkinson disease	P01240	hSel10	HUMAN|HGNC=13607|UniProtKB=Q9UKB1	F-box/WD repeat-containing protein 11	ISS			PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	MACMU|Ensembl=ENSMMUG00000014627|UniProtKB=F7GNE4	Catenin beta-1	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00048	PI3 kinase pathway	P01188	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P05917	Opioid proopiomelanocortin pathway	P06009	K+ channel	MOUSE|MGI=MGI=3521816|UniProtKB=Q3LS21	Potassium channel subfamily K member 9	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00005	Angiogenesis	P00211	GSK3beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00021	FGF signaling pathway	P00636	FGFR1-4	XENTR|Xenbase=XB-GENE-1018554|UniProtKB=Q28J96	Fibroblast growth factor receptor	ISS	2172985	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P00051	TCA cycle	P01268	Aconitase	GEOSL|EnsemblGenome=GSU2445|UniProtKB=Q74AD1	Aconitate hydratase, putative	RCA			PTHR43160:SF3	ACONITATE HYDRATASE, MITOCHONDRIAL
P00036	Interleukin signaling pathway	P00990	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00046	Oxidative stress response	P01135	p38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	TAS	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00021	FGF signaling pathway	P00638	PLCgamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00057	Wnt signaling pathway	P01429	Axin	MACMU|Ensembl=ENSMMUG00000000605|UniProtKB=F6Y8V8	Uncharacterized protein	ISS	9554852	PubMed	PTHR10845:SF11	AXIN-1
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=12778|UniProtKB=O14904	Protein Wnt-9a	IDA	11266476	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P00019	Endothelin signaling pathway	P00566	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	11204774	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00036	Interleukin signaling pathway	P00973	PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	ENTHI|EnsemblGenome=EHI_197840|UniProtKB=C4M8K6	Rho family GTPase	ISS	4757952	gi	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P02734	Chorismate biosynthesis	P02871	2-Deoxy-7-phosphoheptulonate synthase	YEAST|SGD=S000002442|UniProtKB=P14843	Phospho-2-dehydro-3-deoxyheptonate aldolase, phenylalanine-inhibited	ISS			PTHR21225:SF17	PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, PHENYLALANINE-INHIBITED
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00059	p53 pathway	P01485	p53	CANLF|Ensembl=ENSCAFG00000013961|UniProtKB=F1PL57	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	8946911	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P02741	Flavin biosynthesis	P02936	FAD synthetase	MOUSE|MGI=MGI=2443030|UniProtKB=Q8R123	FAD synthase	RCA			PTHR23293:SF9	FAD SYNTHASE
P02738	De novo purine biosynthesis	P02909	GDP reductase	ARATH|TAIR=AT3G23580|UniProtKB=P50651	Ribonucleoside-diphosphate reductase small chain A	ISS			PTHR23409:SF24	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN A
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	NAS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IGI	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04440	Beta2	MOUSE|MGI=MGI=87938|UniProtKB=P18762	Beta-2 adrenergic receptor	ISS	7669252	PubMed	PTHR24248:SF21	BETA-2 ADRENERGIC RECEPTOR
P00006	Apoptosis signaling pathway	P00269	MAPK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01314	nck	MONDO|Ensembl=ENSMODG00000018540|UniProtKB=F7GD33	Uncharacterized protein	ISS	11689432	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00047	PDGF signaling pathway	P01161	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01369	MKK1	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Ensembl=ENSBTAG00000013632|UniProtKB=E1B965	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	TAS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00239	Eph	XENTR|Xenbase=XB-GENE-1011783|UniProtKB=F7B9D9	Uncharacterized protein (Fragment)	ISS			PTHR11304:SF17	EPHRIN-B1
P00059	p53 pathway	G01569	Maspin	CANLF|Ensembl=ENSCAFG00000024647|UniProtKB=E2REC1	Uncharacterized protein	ISS	10692390	PubMed	PTHR11461:SF55	SERPIN B5
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00564	Rac	CAEEL|WormBase=WBGene00004287|UniProtKB=Q94124	Ras-related protein rac-2	IGI	21571425	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00006	Apoptosis signaling pathway	P00274	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	RHOBA|EnsemblGenome=RB7247|UniProtKB=Q7UNZ8	Glutamine synthetase	ISS			PTHR20852:SF57	GLUTAMINE SYNTHETASE 2 CYTOPLASMIC
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00896	Insulin IGF	RAT|RGD=2915|UniProtKB=P01322	Insulin-1	ISS			PTHR11454:SF24	INSULIN-1
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008422|UniProtKB=F6VUT7	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	PANTR|Ensembl=ENSPTRG00000009518|UniProtKB=H2QDN0	Mitogen-activated protein kinase kinase kinase 3	ISS	8649450	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P02763	Peptidoglycan biosynthesis	P03091	D-alanine-D-alanine ligase	LEPIN|EnsemblGenome=LA_2699|UniProtKB=Q8F2R9	D-alanine--D-alanine ligase	ISS			PTHR23132:SF12	D-ALANINE--D-ALANINE LIGASE B
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00047	PDGF signaling pathway	P01150	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P05913	Enkephalin release	P05974	G-Protein (i)	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02743	Formyltetrahydroformate biosynthesis	P02954	Thymidylate synthase	MOUSE|MGI=MGI=98878|UniProtKB=P07607	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00005	Angiogenesis	P00219	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	ISS	176892	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P02727	Androgen/estrogene/progesterone biosynthesis	P02826	Estradiol 17beta-dehydrogenase	MOUSE|MGI=MGI=1096386|UniProtKB=P51658	Estradiol 17-beta-dehydrogenase 2	RCA			PTHR43313:SF3	ESTRADIOL 17-BETA-DEHYDROGENASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MACMU|Ensembl=ENSMMUG00000016428|UniProtKB=F7GU00	Metabotropic glutamate receptor 1 isoform alpha	ISS	12351712	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00012	Cadherin signaling pathway	P00463	betacatenin	ORNAN|Ensembl=ENSOANG00000006811|UniProtKB=F6WBD5	Uncharacterized protein	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	SCHPO|PomBase=SPAC26A3.05|UniProtKB=Q10161	Probable clathrin heavy chain	IDA	9388255	PubMed	PTHR10292:SF1	CLATHRIN HEAVY CHAIN
P06664	Gonadotropin-releasing hormone receptor pathway	G06880	Scg2	MOUSE|MGI=MGI=103033|UniProtKB=Q03517	Secretogranin-2	RCA			PTHR15119:SF0	SECRETOGRANIN-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00019	Endothelin signaling pathway	P00568	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	10395542	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00046	Oxidative stress response	P01129	JNK1/2	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00046	Oxidative stress response	P01129	JNK1/2	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CAEBR|Gene=CBG02401|UniProtKB=A8WUE7	Protein CBR-NMR-1	ISS	11554554	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00015	Circadian clock system	P00502	Casein kinase I	CHICK|Ensembl=ENSGALG00000002719|UniProtKB=E1BVW0	Uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IDA	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P02748	Isoleucine biosynthesis	P02996	Ketol-acid reductoisomerase	GLOVI|EnsemblGenome=BAC90598|UniProtKB=Q7NH80	Ketol-acid reductoisomerase	ISS			PTHR21371:SF1	KETOL-ACID REDUCTOISOMERASE, CHLOROPLASTIC
P00060	Ubiquitin proteasome pathway	P01490	E3	CHICK|Ensembl=ENSGALG00000014290|UniProtKB=F1NIP7	Uncharacterized protein	ISS			PTHR44020:SF2	UBIQUITIN-CONJUGATING ENZYME E2 K
P04395	Vasopressin synthesis	P04589	Signal Peptidase	CAEEL|WormBase=WBGene00021844|UniProtKB=Q9N3D0	Signal peptidase complex catalytic subunit SEC11	IC	2092035	PubMed	PTHR10806:SF6	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00059	p53 pathway	P04626	GADD45	HUMAN|HGNC=4096|UniProtKB=O75293	Growth arrest and DNA damage-inducible protein GADD45 beta	IGI	10097101	PubMed	PTHR10411:SF5	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 BETA
P00011	Blood coagulation	P00443	Fibrin polymer cross-linked	HUMAN|HGNC=3694|UniProtKB=P02679	Fibrinogen gamma chain	ISS	223170	gi	PTHR19143:SF338	FIBRINOGEN GAMMA CHAIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	ISS	176910	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01423	p38MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05918	p38 MAPK pathway	P06015	p38gamma	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	RCA	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00034	Integrin signalling pathway	P00925	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IDA	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00059	p53 pathway	P01480	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00009	Axon guidance mediated by netrin	P00366	Rac	MACMU|Ensembl=ENSMMUG00000021075|UniProtKB=F7GY91	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00034	Integrin signalling pathway	P00916	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IPI	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00057	Wnt signaling pathway	P01443	Phospholipase C	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	2837282	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	TAKRU|Ensembl=ENSTRUG00000003589|UniProtKB=H2S7P7	Uncharacterized protein	ISS	11248120	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=2683547|UniProtKB=Q4KWH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1	ISS	10934033	PubMed	PTHR10336:SF51	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-1
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01456	beta-arrestin	MACMU|Ensembl=ENSMMUG00000017654|UniProtKB=F6UI32	Beta-arrestin-2 isoform 1	ISS	9388255	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00009	Axon guidance mediated by netrin	P00364	cdc42	XENTR|Xenbase=XB-GENE-967585|UniProtKB=Q28BZ0	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	DROME|FlyBase=FBgn0260964|UniProtKB=Q8IH57	GH10249p	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00057	Wnt signaling pathway	P01465	Ggamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00012	Cadherin signaling pathway	P00475	Frizzled	DANRE|ZFIN=ZDB-GENE-000328-3|UniProtKB=Q9YI00	Frizzled 8a protein	IDA	11212302	PubMed	PTHR11309:SF90	FRIZZLED-8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT1G07880|UniProtKB=Q9LQQ9	Mitogen-activated protein kinase 13	ISS	9836510	gi	PTHR24055:SF185	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	MOUSE|MGI=MGI=99946|UniProtKB=Q61817	Cyclic AMP-responsive element-binding protein 3	ISS	608972	OMIM	PTHR22952:SF100	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CANLF|Ensembl=ENSCAFG00000005662|UniProtKB=E2R907	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00038	JAK/STAT signaling pathway	P01027	STAT	TAKRU|Ensembl=ENSTRUG00000015454|UniProtKB=H2URF8	Signal transducer and activator of transcription	ISS			PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00023	General transcription regulation	P00670	TBP	PANTR|Ensembl=ENSPTRG00000018624|UniProtKB=A6H914	TATA box binding protein-like 1	ISS	10082669	PubMed	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00029	Huntington disease	P00790	beta-Tubulin	ARATH|TAIR=AT5G62690|UniProtKB=Q56YW9	Tubulin beta-2 chain	TAS	12932731	PubMed	PTHR11588:SF259	TUBULIN BETA-2 CHAIN-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	MONDO|Ensembl=ENSMODG00000014076|UniProtKB=F6R525	Uncharacterized protein	ISS			PTHR12458:SF8	CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MOUSE|MGI=MGI=1913418|UniProtKB=Q9ESF4	Protein lifeguard 1	ISS			PTHR23291:SF16	PROTEIN LIFEGUARD 1
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	RAT|RGD=619966|UniProtKB=F1LQT1	Adenylate cyclase 7	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01177	P110ACT	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DICDI|dictyBase=DDB_G0277143|UniProtKB=P36408	Guanine nucleotide-binding protein subunit beta	IC	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00010	B cell activation	P00381	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	RAT|RGD=620351|UniProtKB=P18265	Glycogen synthase kinase-3 alpha	ISS	11995474	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02746	Heme biosynthesis	P02973	Uroporphyrinogen methyltransferase	FUSNN|EnsemblGenome=FN0644|UniProtKB=Q8RFP6	Uroporphyrin-III C-methyltransferase	ISS			PTHR21091:SF16	SIROHEME SYNTHASE
P00049	Parkinson disease	P01223	UbcH8	CAEBR|Gene=CBG16512|UniProtKB=A8XPD5	Protein CBR-UBC-18	ISS			PTHR24068:SF116	AT26201P-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00038	JAK/STAT signaling pathway	P01033	PTP	HUMAN|HGNC=9666|UniProtKB=P08575	Receptor-type tyrosine-protein phosphatase C	ISS	1672451	PubMed	PTHR19134:SF284	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DROME|FlyBase=FBgn0004921|UniProtKB=P38040	Guanine nucleotide-binding protein subunit gamma-1	IC			PTHR13809:SF3	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA-RELATED
P00046	Oxidative stress response	P01135	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	TAS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12805548	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IPI	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MOUSE|MGI=MGI=3710243|UniProtKB=A2AQP0	Myosin-7B	ISS	89264452	PubMed	PTHR13140:SF358	MYOSIN-7B
P00047	PDGF signaling pathway	P01143	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	97449291	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00019	Endothelin signaling pathway	P00566	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00012	Cadherin signaling pathway	P00465	TCF/LEF	HUMAN|HGNC=11640|UniProtKB=Q9HCS4	Transcription factor 7-like 1	ISS	9118222	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P02723	Adenine and hypoxanthine salvage pathway	P02805	Adenine phosphorylase	MYCTU|EnsemblGenome=Rv3307|UniProtKB=P9WP01	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00047	PDGF signaling pathway	P01173	STAT	RAT|RGD=1309063|UniProtKB=Q1KQ07	Signal transducer and activator of transcription	ISS	12039028	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00059	p53 pathway	G04705	p48	MOUSE|MGI=MGI=1355314|UniProtKB=Q99J79	DNA damage-binding protein 2	ISS			PTHR15169:SF2	DNA DAMAGE-BINDING PROTEIN 2
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00260	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05974	G-Protein (i)	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	IC	1482697	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04395	Vasopressin synthesis	P04589	Signal Peptidase	ANOGA|EnsemblGenome=AGAP011842|UniProtKB=Q7PZC7	AGAP011842-PA	IC	7788527	PubMed	PTHR13085:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 2
P04393	Ras Pathway	P04557	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04393	Ras Pathway	P04561	SRF	BOVIN|Ensembl=ENSBTAG00000012777|UniProtKB=E1BJP4	Uncharacterized protein	ISS	8660892	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00029	Huntington disease	P00790	beta-Tubulin	DROME|FlyBase=FBgn0003887|UniProtKB=Q24560	Tubulin beta-1 chain	TAS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01150	PKC	BOVIN|Ensembl=ENSBTAG00000021900|UniProtKB=F1MFK1	Uncharacterized protein	ISS	11554554	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00006	Apoptosis signaling pathway	P00302	ATF	PANTR|Ensembl=ENSPTRG00000014398|UniProtKB=H2QLQ7	Activating transcription factor 4 (Tax-responsive enhancer element B67)	ISS	11390664	PubMed	PTHR13044:SF2	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-4
P05913	Enkephalin release	P05977	G-Protein (s)	ANOGA|EnsemblGenome=AGAP005913|UniProtKB=Q7Q6D2	AGAP005913-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00010	B cell activation	P00402	Jnk	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	P01438	PP2A	TAKRU|Ensembl=ENSTRUG00000008018|UniProtKB=H2T5N4	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=1306541|UniProtKB=D3ZVF3	Phosphoinositide-3-kinase, class 2, beta polypeptide (Predicted)	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	RAT|RGD=1305581|UniProtKB=B2RYB8	Integrin beta	ISS	3487386	PubMed	PTHR10082:SF15	INTEGRIN BETA-2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	P01450	Bcl9	PANTR|Ensembl=ENSPTRG00000001222|UniProtKB=H2PZV0	B-cell CLL/lymphoma 9	ISS	11955446	PubMed	PTHR15185:SF5	B-CELL CLL/LYMPHOMA 9 PROTEIN
P00012	Cadherin signaling pathway	P00470	F-actin	IXOSC|EnsemblGenome=ISCW024111|UniProtKB=B7PBG2	Actin, putative (Fragment)	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00047	PDGF signaling pathway	P01143	ERK	CHICK|Ensembl=ENSGALG00000004690|UniProtKB=Q5F3W3	Mitogen-activated protein kinase 6	ISS	8444355	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00059	p53 pathway	P04626	GADD45	XENTR|Xenbase=XB-GENE-481955|UniProtKB=Q6DIJ3	Growth arrest and DNA-damage-inducible 45 gamma	ISS	10097101	PubMed	PTHR10411:SF4	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 GAMMA
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	BOVIN|Gene=CACNB1|UniProtKB=Q9MZL7	Voltage-dependent L-type calcium channel subunit beta-1	ISS	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=4403|UniProtKB=P61952	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	IC			PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DROME|FlyBase=FBgn0000044|UniProtKB=P53501	Actin-57B	IDA	14684598	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01098	CHT1	PANTR|Ensembl=ENSPTRG00000012325|UniProtKB=H2QII0	Uncharacterized protein	RCA			PTHR11819:SF129	HIGH AFFINITY CHOLINE TRANSPORTER 1
P00052	TGF-beta signaling pathway	P01288	FKBP12	GLOVI|Gene=BAC88782|UniProtKB=Q7NMC5	Peptidyl-prolyl cis-trans isomerase	ISS			PTHR43811:SF19	39 KDA FK506-BINDING NUCLEAR PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	CAEEL|WormBase=WBGene00001985|UniProtKB=O02100	Presenilin hop-1	TAS	8755489	PubMed	PTHR10202:SF14	PRESENILIN HOP-1
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P02761	Pantothenate biosynthesis	P03067	3-methyl-2-oxobutanoate hydroxymethyltransferase	ARATH|TAIR=AT3G61530|UniProtKB=Q9M315	3-methyl-2-oxobutanoate hydroxymethyltransferase 2, mitochondrial	ISS			PTHR20881:SF7	3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE 2, MITOCHONDRIAL
P05916	Opioid prodynorphin pathway	P06002	G-protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	ISS	1482697	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00012	Cadherin signaling pathway	P00467	alpha-catenin	HUMAN|HGNC=2510|UniProtKB=P26232	Catenin alpha-2	IDA	9362521	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00547	PP2A	DANRE|ZFIN=ZDB-GENE-030904-7|UniProtKB=Q8AXX6	Ppp2r5e2 protein	ISS	8703017	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000008751|UniProtKB=H2QC89	Uncharacterized protein	ISS	12507995	PubMed	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00005	Angiogenesis	P00238	Ras	DANRE|ZFIN=ZDB-GENE-040808-67|UniProtKB=Q6AZA4	K-ras	ISS	10825661	PubMed	PTHR24070:SF186	GTPASE KRAS
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00011	Blood coagulation	P00429	PN2	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	ISS	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05731	GABA-B receptor II signaling	P05760	AC	BOVIN|Ensembl=ENSBTAG00000005464|UniProtKB=E1B9K3	Uncharacterized protein	ISS	93028552	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00025	Hedgehog signaling pathway	P00690	Cubitus interruptus	MOUSE|MGI=MGI=95729|UniProtKB=Q61602	Transcriptional activator GLI3	IDA	10976059	PubMed	PTHR19818:SF5	TRANSCRIPTIONAL ACTIVATOR GLI3
P00048	PI3 kinase pathway	P01202	p85	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-486685|UniProtKB=F6VT32	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00006	Apoptosis signaling pathway	P00310	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00005	Angiogenesis	P00236	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	ARATH|TAIR=AT4G34460|UniProtKB=P49177	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF48	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MONDO|Ensembl=ENSMODG00000013079|UniProtKB=F7FB74	Uncharacterized protein	ISS	1648176	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IPI	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04555	PDK	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	ORNAN|Ensembl=ENSOANG00000013961|UniProtKB=F6VPY1	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CHICK|Ensembl=ENSGALG00000027629|UniProtKB=Q5ZJ03	Guanine nucleotide-binding protein subunit gamma	IDA	9754712	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00034	Integrin signalling pathway	P00916	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IPI	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00052	TGF-beta signaling pathway	P01292	RSmads	MONDO|Ensembl=ENSMODG00000015152|UniProtKB=F7CFQ6	Mothers against decapentaplegic homolog	ISS	12736218	PubMed	PTHR13703:SF36	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5
P00006	Apoptosis signaling pathway	P00274	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00060	Ubiquitin proteasome pathway	P01491	E2	MACMU|Ensembl=ENSMMUG00000004096|UniProtKB=F6ZC17	Uncharacterized protein	ISS	10888878	PubMed	PTHR24068:SF67	UBIQUITIN-CONJUGATING ENZYME E2 L3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	SCHPO|PomBase=SPAC17G8.14c|UniProtKB=P36582	Protein kinase C-like 1	IC	8491190	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	BOVIN|Gene=ACTB|UniProtKB=P60712	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	ISS	10571227	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00046	Oxidative stress response	P01126	ATF2	CANLF|Ensembl=ENSCAFG00000013332|UniProtKB=F1PCQ4	Uncharacterized protein	ISS	9819389	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00025	Hedgehog signaling pathway	P00682	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	CHICK|Ensembl=ENSGALG00000002550|UniProtKB=O57340	Thyrotropin subunit beta	ISS	15927770	PubMed	PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P00052	TGF-beta signaling pathway	P01284	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00057	Wnt signaling pathway	P01472	Histone deacetylase	MACMU|Ensembl=ENSMMUG00000008937|UniProtKB=F7EW26	Histone deacetylase	ISS	10485845	PubMed	PTHR10625:SF171	HISTONE DEACETYLASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MOUSE|MGI=MGI=109248|UniProtKB=Q920H4	Muscarinic acetylcholine receptor M5	TAS	8100450	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00047	PDGF signaling pathway	P01173	STAT	CANLF|Ensembl=ENSCAFG00000000163|UniProtKB=F1PAY3	Signal transducer and activator of transcription	ISS	8085155	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00053	T cell activation	P01294	NFAT	PANTR|Ensembl=ENSPTRG00000006218|UniProtKB=H2Q834	Uncharacterized protein	ISS	12787506	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00898	FKHR	PANTR|Ensembl=ENSPTRG00000018476|UniProtKB=H2R710	Forkhead box O3	ISS	12048180	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00047	PDGF signaling pathway	P01142	p90RSK	PANTR|Ensembl=ENSPTRG00000009477|UniProtKB=H2QDK7	Ribosomal protein S6 kinase	ISS	15116068	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00047	PDGF signaling pathway	P01175	Shc	HUMAN|HGNC=29869|UniProtKB=P98077	SHC-transforming protein 2	ISS	600560	OMIM	PTHR10337:SF5	SHC-TRANSFORMING PROTEIN 2
P00054	Toll receptor signaling pathway	P01342	IRAK4	PANTR|Ensembl=ENSPTRG00000004845|UniProtKB=H2Q5R2	Interleukin-1 receptor-associated kinase 4	ISS			PTHR24419:SF22	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ORYSJ|EnsemblGenome=OS02G0148100|UniProtKB=Q6Z437	Mitogen-activated protein kinase 3	IDA			PTHR24055:SF216	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=4594|UniProtKB=Q14416	Metabotropic glutamate receptor 2	IDA	9407094	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00036	Interleukin signaling pathway	P00990	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00474	Wnt	ORNAN|Gene=WNT2|UniProtKB=Q07DZ8	Protein Wnt-2	ISS	11266476	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P04393	Ras Pathway	P04569	Cdc42	XENTR|Xenbase=XB-GENE-967585|UniProtKB=Q28BZ0	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00759	PDEalphabeta	HUMAN|HGNC=8786|UniProtKB=P35913	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	RCA	P35913	SPACC	PTHR11347:SF73	ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT BETA
P04393	Ras Pathway	P04572	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04398	p53 pathway feedback loops 2	P04651	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00021	FGF signaling pathway	P00640	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00936	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IPI	1171954	gi	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00057	Wnt signaling pathway	P01454	betaTrCP	RAT|RGD=1309121|UniProtKB=A0A0G2JVE0	Protein Fbxw11	ISS	10074433	PubMed	PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-1712|UniProtKB=Q6PBY0	Guanine nucleotide binding protein (G protein), beta 5	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00021	FGF signaling pathway	P00623	FGF	RAT|RGD=2607|UniProtKB=P63076	Fibroblast growth factor 17	ISS	9514906	PubMed	PTHR11486:SF71	FIBROBLAST GROWTH FACTOR 17
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	11956331	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P02771	Pyrimidine Metabolism	P03124	Methylmalonate Semialdehyde Dehydrogenase	RAT|RGD=621556|UniProtKB=Q02253	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	IPI	2708830	gi	PTHR43866:SF3	METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE  ACYLATING , MITOCHONDRIAL
P00049	Parkinson disease	P01227	20S proteasome	TRYB2|Gene=Tb11.02.5170|UniProtKB=Q384T8	Proteasome subunit beta type	TAS	12859888	PubMed	PTHR11599:SF62	PROTEASOME SUBUNIT BETA TYPE-3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DROME|FlyBase=FBgn0259680|UniProtKB=P83099	Putative protein kinase C delta type homolog	ISS	15572354	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	10644715	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	CHICK|Gene=ACTG2|UniProtKB=P63270	Actin, gamma-enteric smooth muscle	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00566	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01063	CAT	DROME|FlyBase=FBgn0000303|UniProtKB=P07668	Choline O-acetyltransferase	IC	92155737	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	ANOGA|EnsemblGenome=AGAP005569|UniProtKB=Q7Q707	AGAP005569-PA	ISS	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00021	FGF signaling pathway	P00641	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IDA	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P06959	CCKR signaling map	G06978	CHGA	HUMAN|HGNC=1929|UniProtKB=P10645	Chromogranin-A	RCA	11459816	PubMed	PTHR10583:SF1	CHROMOGRANIN-A
P00056	VEGF signaling pathway	P01417	Raf	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS	12068308	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00036	Interleukin signaling pathway	P00980	IRS1/2	MOUSE|MGI=MGI=99454|UniProtKB=P35569	Insulin receptor substrate 1	IC	11701440	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00029	Huntington disease	P00780	Microtubule	MACMU|Ensembl=ENSMMUG00000011029|UniProtKB=F7DCY3	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CHICK|Ensembl=ENSGALG00000011086|UniProtKB=P68139	Actin, alpha skeletal muscle	ISS	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P02756	N-acetylglucosamine metabolism	P03036	N-acetylglucosamine-6-phosphate deacetylase	ECOLI|EcoGene=EG10632|UniProtKB=P0AF18	N-acetylglucosamine-6-phosphate deacetylase	ISS			PTHR11113:SF1	N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE
P00057	Wnt signaling pathway	P01446	Calcineurin	ORNAN|Ensembl=ENSOANG00000010781|UniProtKB=F6X434	Serine/threonine-protein phosphatase	ISS	12091710	PubMed	PTHR11668:SF186	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT GAMMA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	CRYNJ|EnsemblGenome=CNA04650|UniProtKB=Q5KP06	Actin	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00053	T cell activation	P01307	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00006	Apoptosis signaling pathway	P00264	c-IAP1,2	PANTR|Ensembl=ENSPTRG00000004213|UniProtKB=H2Q4M6	Baculoviral IAP repeat containing 2	ISS			PTHR10044:SF79	BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00053	T cell activation	P01323	I kappa B	CHICK|Gene=NFKBIA|UniProtKB=Q91974	NF-kappa-B inhibitor alpha	IGI	10811867	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	RAT|RGD=3765|UniProtKB=P30938	Somatostatin receptor type 5	IDA			PTHR24229:SF20	SOMATOSTATIN RECEPTOR TYPE 5
P00047	PDGF signaling pathway	P01159	SOS	CHICK|Ensembl=ENSGALG00000013224|UniProtKB=F1NMA4	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00029	Huntington disease	G01530	HTT	MOUSE|MGI=MGI=96067|UniProtKB=P42859	Huntingtin	IDA	7620118	PubMed	PTHR10170:SF10	HUNTINGTIN
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00053	T cell activation	P01305	Calmodulin	BRAFL|Gene=BRAFLDRAFT_87235|UniProtKB=C3ZEV9	Putative uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00029	Huntington disease	P00810	GAPDH	ARATH|TAIR=AT1G12900|UniProtKB=Q9LPW0	Glyceraldehyde-3-phosphate dehydrogenase GAPA2, chloroplastic	IPI			PTHR43148:SF5	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE GAPA1, CHLOROPLASTIC-RELATED
P00029	Huntington disease	P00786	ARF	PANTR|Ensembl=ENSPTRG00000002066|UniProtKB=G2HIU2	ADP-ribosylation factor 1	ISS	11752622	PubMed	PTHR11711:SF234	ADP-RIBOSYLATION FACTOR 1
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00047	PDGF signaling pathway	P01154	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00004	Alzheimer disease-presenilin pathway	P00178	BACE-1 pro-domain	MONDO|Ensembl=ENSMODG00000013692|UniProtKB=F6QP52	Uncharacterized protein	ISS	10531052	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05913	Enkephalin release	P05972	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00018	EGF receptor signaling pathway	P00551	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00010	B cell activation	P00374	Lyn	MACMU|Ensembl=ENSMMUG00000014149|UniProtKB=F7BV42	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CHICK|Ensembl=ENSGALG00000009287|UniProtKB=O93602	Cyclic AMP-dependent transcription factor ATF-2	TAS	10207617	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00057	Wnt signaling pathway	P01453	Ebi	PANTR|Ensembl=ENSPTRG00000022475|UniProtKB=H2QY99	Uncharacterized protein	ISS	11389839	PubMed	PTHR22846:SF50	F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN TBL1Y
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00833	RGS	MACMU|Ensembl=ENSMMUG00000005185|UniProtKB=F7CYN6	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF184	REGULATOR OF G-PROTEIN SIGNALING 4
P00019	Endothelin signaling pathway	P00590	IP3 R	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P05918	p38 MAPK pathway	P06025	SRF	MOUSE|MGI=MGI=106658|UniProtKB=Q9JM73	Serum response factor	ISS	15647354	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Ensembl=ENSPTRG00000022245|UniProtKB=H2QZ29	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00007	Axon guidance mediated by semaphorins	P00340	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04393	Ras Pathway	P04557	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DROME|FlyBase=FBgn0000047|UniProtKB=P83967	Actin, indirect flight muscle	IC	10974003	PubMed	PTHR11937:SF368	ACTIN, INDIRECT FLIGHT MUSCLE
P02746	Heme biosynthesis	P02983	Hydroxymethylbilane synthase	CANLF|Ensembl=ENSCAFG00000012342|UniProtKB=E2RTD6	Uncharacterized protein	ISS			PTHR11557:SF0	PORPHOBILINOGEN DEAMINASE
P00056	VEGF signaling pathway	P01417	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04665	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00015	Circadian clock system	P00504	Per	DANRE|ZFIN=ZDB-GENE-000804-1|UniProtKB=F1RDZ4	Uncharacterized protein	ISS			PTHR11269:SF13	PERIOD CIRCADIAN PROTEIN HOMOLOG 3
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95814|UniProtKB=Q60934	Glutamate receptor ionotropic, kainate 1	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	HUMAN|HGNC=4041|UniProtKB=Q9NPG1	Frizzled-3	TAS	12549854	PubMed	PTHR11309:SF22	FRIZZLED-3
P04396	Vitamin D metabolism and pathway	P04607	FDX	MOUSE|MGI=MGI=1915415|UniProtKB=Q9CPW2	Adrenodoxin-like protein, mitochondrial	ISS			PTHR23426:SF45	ADRENODOXIN-LIKE PROTEIN, MITOCHONDRIAL
P00016	Cytoskeletal regulation by Rho GTPase	P00516	Ena/VASP	RAT|RGD=1307666|UniProtKB=A0A0G2K6I4	Protein Enah	ISS			PTHR11202:SF1	PROTEIN ENABLED HOMOLOG
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	HUMAN|HGNC=1497|UniProtKB=O14936	Peripheral plasma membrane protein CASK	ISS	11430913	PubMed	PTHR23122:SF40	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P00021	FGF signaling pathway	P00624	14-3-3	CHLRE|EnsemblGenome=CHLREDRAFT_185967|UniProtKB=A8JGV6	14-3-3 protein	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00050	Plasminogen activating cascade	P01253	Fibrin	HUMAN|HGNC=3661|UniProtKB=P02671	Fibrinogen alpha chain	IDA	6575700	PubMed	PTHR19143:SF232	FIBRINOGEN ALPHA CHAIN
P02775	Salvage pyrimidine ribonucleotides	P03155	Cytosine deaminase	CHLTR|EnsemblGenome=CT_844|UniProtKB=O84851	tRNA-specific adenosine deaminase	ISS			PTHR11079:SF149	TRNA-SPECIFIC ADENOSINE DEAMINASE
P02723	Adenine and hypoxanthine salvage pathway	P02805	Adenine phosphorylase	MOUSE|MGI=MGI=97365|UniProtKB=P23492	Purine nucleoside phosphorylase	ISS	7903568	PubMed	PTHR11904:SF12	PURINE NUCLEOSIDE PHOSPHORYLASE
P00019	Endothelin signaling pathway	P00572	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MACMU|Ensembl=ENSMMUG00000009778|UniProtKB=F6Y1M7	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF385	MYOSIN-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	HUMAN|HGNC=4587|UniProtKB=Q14957	Glutamate receptor ionotropic, NMDA 2C	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	BOVIN|Ensembl=ENSBTAG00000039794|UniProtKB=P35507	Casein kinase I isoform beta	IDA	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P05913	Enkephalin release	P05972	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00645	Rac	ENTHI|EnsemblGenome=EHI_129750|UniProtKB=C4M5Q7	Rho family GTPase	IGI	8649368	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00019	Endothelin signaling pathway	P00567	PKG	HUMAN|HGNC=9416|UniProtKB=Q13237	cGMP-dependent protein kinase 2	IGI	12764134	PubMed	PTHR24353:SF24	SUBFAMILY NOT NAMED
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-478663|UniProtKB=F7EG64	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	P01457	GBeta	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00029	Huntington disease	P00807	Actin	PANTR|Ensembl=ENSPTRG00000006890|UniProtKB=H2Q943	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	RAT|RGD=620112|UniProtKB=Q99MA1	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	ISS	9865691	PubMed	PTHR17045:SF7	CBP/P300-INTERACTING TRANSACTIVATOR 2
P00034	Integrin signalling pathway	P00927	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	10540223	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00048	PI3 kinase pathway	P01179	PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00004	Alzheimer disease-presenilin pathway	P00128	Erb-B4	PANTR|Ensembl=ENSPTRG00000012883|UniProtKB=H2QJC5	Receptor protein-tyrosine kinase	ISS	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P06959	CCKR signaling map	P07170	TAK1	HUMAN|HGNC=7972|UniProtKB=P49116	Nuclear receptor subfamily 2 group C member 2	RCA	12740336	PubMed	PTHR24083:SF48	NUCLEAR RECEPTOR SUBFAMILY 2 GROUP C MEMBER 2
P00053	T cell activation	P01305	Calmodulin	DICDI|dictyBase=DDB_G0279407|UniProtKB=P02599	Calmodulin	ISS			PTHR23050:SF245	AT16150P-RELATED
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	RCA	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04398	p53 pathway feedback loops 2	P04669	ATM	BOVIN|Ensembl=ENSBTAG00000011529|UniProtKB=F1MLY7	Uncharacterized protein	ISS	10196661	PubMed	PTHR11139:SF69	SERINE/THREONINE-PROTEIN KINASE ATR
P00029	Huntington disease	P00805	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02738	De novo purine biosynthesis	P02892	5-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase	CAEEL|WormBase=WBGene00011064|UniProtKB=Q21774	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00056	VEGF signaling pathway	P01408	Akt/PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00053	T cell activation	P01305	Calmodulin	CANLF|Ensembl=ENSCAFG00000017516|UniProtKB=E2REK6	Uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF311	CALMODULIN
P00010	B cell activation	P00373	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CAEEL|WormBase=WBGene00001187|UniProtKB=Q8MQA1	Uncharacterized protein	IC	15737619	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P05916	Opioid prodynorphin pathway	P06002	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06768	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	RCA	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00058	mRNA splicing	P01474	U5	CANLF|Ensembl=ENSCAFG00000011149|UniProtKB=E2R016	Uncharacterized protein	ISS	9774689	PubMed	PTHR44006:SF1	U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN
P00059	p53 pathway	G04694	p110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00012	Cadherin signaling pathway	P00474	Wnt	RAT|RGD=628850|UniProtKB=B1WBR9	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	XENTR|Xenbase=XB-GENE-491618|UniProtKB=Q6P378	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00807	Actin	TRIVA|Gene=TVAG_090470|UniProtKB=A2FA04	Actin	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02774	Salvage pyrimidine deoxyribonucleotides	P03146	Deoxyuridine kinase	CAEEL|WormBase=WBGene00006568|UniProtKB=G5EEZ5	Thymidine kinase	ISS			PTHR11441:SF0	THYMIDINE KINASE, CYTOSOLIC
P00049	Parkinson disease	P01208	Hsp70	CANLF|Ensembl=ENSCAFG00000020196|UniProtKB=F1PIC7	Uncharacterized protein	ISS	10934466	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00004	Alzheimer disease-presenilin pathway	P00110	Ire-1 N-terminal fragment	ORYSJ|EnsemblGenome=OS07G0471000|UniProtKB=Q7XIT1	Os07g0471000 protein	IDA	10619423	PubMed	PTHR13954:SF6	INOSITOL-REQUIRING ENZYME-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	ORNAN|Ensembl=ENSOANG00000012083|UniProtKB=F7FPY5	Actin-related protein 2/3 complex subunit 4	ISS	9230079	PubMed	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	CHICK|Ensembl=ENSGALG00000003498|UniProtKB=Q5ZMS1	Transcription initiation factor TFIID subunit 8	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=621505|UniProtKB=P0C865	Mitogen-activated protein kinase 7	ISS	15085193	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00056	VEGF signaling pathway	P01407	Erk	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	BOVIN|Ensembl=ENSBTAG00000021988|UniProtKB=Q0VC91	Suppressor of cytokine signaling 4	ISS	15032587	PubMed	PTHR44282:SF2	SUPPRESSOR OF CYTOKINE SIGNALING 4
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P06664	Gonadotropin-releasing hormone receptor pathway	P06832	c-Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	RCA	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01161	Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	ISS	12068308	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00034	Integrin signalling pathway	P00949	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	7798194	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DANRE|ZFIN=ZDB-GENE-030131-6503|UniProtKB=Q7ZUC5	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF297	PROTEIN KINASE C DELTA TYPE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	NEUCR|EnsemblGenome=EFNCRG00000003892|UniProtKB=Q9UUY8	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P02746	Heme biosynthesis	P02982	Protoheme IX farnesyl transferase	ARATH|TAIR=AT4G23660|UniProtKB=Q93YP7	4-hydroxybenzoate polyprenyltransferase, mitochondrial	ISS			PTHR11048:SF28	4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL
P00047	PDGF signaling pathway	P01153	GSK3	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IDA	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05918	p38 MAPK pathway	P05922	MKP1	BOVIN|Ensembl=ENSBTAG00000013863|UniProtKB=F1MI99	Dual specificity protein phosphatase	ISS			PTHR10159:SF309	DUAL SPECIFICITY PROTEIN PHOSPHATASE 1
P00017	DNA replication	P00529	RFC	HUMAN|HGNC=9972|UniProtKB=P35249	Replication factor C subunit 4	RCA			PTHR11669:SF20	REPLICATION FACTOR C SUBUNIT 4
P00060	Ubiquitin proteasome pathway	P01491	E2	ORNAN|Ensembl=ENSOANG00000007266|UniProtKB=F7CL20	Uncharacterized protein (Fragment)	ISS			PTHR43915:SF3	UBIQUITIN-CONJUGATING ENZYME E2 VARIANT 2
P00059	p53 pathway	P04612	HDAC1	CHICK|Ensembl=ENSGALG00000003297|UniProtKB=P56517	Histone deacetylase 1	IDA	10485845	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P00025	Hedgehog signaling pathway	P00682	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	XENTR|Xenbase=XB-GENE-957248|UniProtKB=Q6GLE6	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	ORNAN|Ensembl=ENSOANG00000013961|UniProtKB=F6VPY1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00056	VEGF signaling pathway	P01418	Paxillin	DROME|FlyBase=FBgn0051988|UniProtKB=Q8T0V8	GH01042p	ISS			PTHR24216:SF46	GH01042P-RELATED
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MACMU|Ensembl=ENSMMUG00000017374|UniProtKB=F7H6T7	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00029	Huntington disease	P00807	Actin	CAEEL|WormBase=WBGene00000063|UniProtKB=P0DM41	Actin-1	IDA	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00005	Angiogenesis	P00221	JNK1	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS			PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00807	Actin	DANRE|ZFIN=ZDB-GENE-000329-3|UniProtKB=Q7ZVF9	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00007	Axon guidance mediated by semaphorins	P00341	Rho	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	ISS	12039949	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01438	PP2A	RAT|RGD=3380|UniProtKB=P63331	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	IDA	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00020	FAS signaling pathway	P00606	Caspase10	HUMAN|HGNC=1500|UniProtKB=Q92851	Caspase-10	IGI	8755496	PubMed	PTHR10454:SF26	CASPASE-10
P00029	Huntington disease	P00805	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01160	IP3 receptor	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IGI	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04397	p53 pathway by glucose deprivation	P04641	Akt	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00223	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	ECOLI|EcoGene=EG10661|UniProtKB=P69924	Ribonucleoside-diphosphate reductase 1 subunit beta	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00057	Wnt signaling pathway	P01435	SWI/SNF	ANOGA|EnsemblGenome=AGAP010700|UniProtKB=Q7QE14	AGAP010700-PA	IDA	11532957	PubMed	PTHR10799:SF879	CHROMATIN-REMODELING COMPLEX ATPASE CHAIN ISWI
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	2837282	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000004742|UniProtKB=H2Q5K1	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DROME|FlyBase=FBgn0000489|UniProtKB=P16912	Protein kinase DC2	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PHYPA|Gene=PHYPADRAFT_109052|UniProtKB=A9TZ58	Actin 5	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	BOVIN|Ensembl=ENSBTAG00000012628|UniProtKB=F1MUJ6	Uncharacterized protein	ISS	94365697	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00046	Oxidative stress response	P01131	MKP5	MACMU|Ensembl=ENSMMUG00000004379|UniProtKB=F7FRM2	Dual specificity protein phosphatase 10 isoform a	ISS	10597297	PubMed	PTHR10159:SF299	DUAL SPECIFICITY PROTEIN PHOSPHATASE 10
P02738	De novo purine biosynthesis	P02902	ADP reductase	MACMU|Ensembl=ENSMMUG00000020765|UniProtKB=F7HEG5	Ribonucleoside-diphosphate reductase subunit M2 B	ISS			PTHR23409:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 B
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000001962|UniProtKB=F6V2H6	Uncharacterized protein	ISS	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00021	FGF signaling pathway	P00627	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	21150461	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	RAT|RGD=628852|UniProtKB=Q02294	Voltage-dependent N-type calcium channel subunit alpha-1B	IDA	14624853	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PHYIT|EnsemblGenome=PITG_15078|UniProtKB=D0NRL5	Actin-like protein	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	IC	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00030	Hypoxia response via HIF activation	P00817	TOR	CHICK|Ensembl=ENSGALG00000003339|UniProtKB=F1NUX4	Uncharacterized protein	ISS	7518356	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00552	Ras	CAEBR|Gene=CBG17997|UniProtKB=A8XSS4	Protein CBR-RAS-2	ISS			PTHR24070:SF268	RAS-RELATED PROTEIN M-RAS
P00005	Angiogenesis	P00256	PLC-gamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	XENTR|Xenbase=XB-GENE-491618|UniProtKB=Q6P378	Actin, cytoplasmic 2	ISS	11889139	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P04384	Gamma-aminobutyric acid synthesis	P04480	GABA aminotransferase	EMENI|EnsemblGenome=CADANIAG00008938|UniProtKB=P14010	4-aminobutyrate aminotransferase	ISS	8133261	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	XENTR|Xenbase=XB-GENE-6469705|UniProtKB=Q6P8G3	Actin, alpha sarcomeric/skeletal	ISS	11889126	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P02738	De novo purine biosynthesis	P02894	IMP cyclohydrolase	CAEBR|Gene=CBG17698|UniProtKB=A8XRH8	Protein CBG17698	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P05918	p38 MAPK pathway	P06018	MNK1	HUMAN|HGNC=7110|UniProtKB=Q9BUB5	MAP kinase-interacting serine/threonine-protein kinase 1	IDA	11575158	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	CIOIN|Ensembl=ENSCING00000008616|UniProtKB=F6T2A6	Uncharacterized protein	ISS			PTHR23050:SF245	AT16150P-RELATED
P00008	Axon guidance mediated by Slit/Robo	P00351	Cxcr4	RAT|RGD=620465|UniProtKB=O08565	C-X-C chemokine receptor type 4	ISS	11591799	PubMed	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	EMENI|EnsemblGenome=CADANIAG00004263|UniProtKB=Q8TFN0	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00029	Huntington disease	P00790	beta-Tubulin	MACMU|Ensembl=ENSMMUG00000008877|UniProtKB=F7DTM8	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00029	Huntington disease	P00774	Dynein complex	HUMAN|HGNC=2961|UniProtKB=Q14204	Cytoplasmic dynein 1 heavy chain 1	IPI	9454836	PubMed	PTHR10676:SF314	CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1
P04393	Ras Pathway	P04578	Rho	XENTR|Xenbase=XB-GENE-489222|UniProtKB=Q28GJ8	Ras homolog gene family, member A	ISS	11360179	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00006	Apoptosis signaling pathway	P00310	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00216	Caspase 9	MACMU|Ensembl=ENSMMUG00000018163|UniProtKB=F7FNC1	Caspase	ISS	8663294	PubMed	PTHR10454:SF157	CASPASE-9
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	MOUSE|MGI=MGI=2679420|UniProtKB=Q3ULB5	Serine/threonine-protein kinase PAK 6	ISS			PTHR24361:SF182	SERINE/THREONINE-PROTEIN KINASE PAK 6
P00018	EGF receptor signaling pathway	P00560	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	MONDO|Ensembl=ENSMODG00000007421|UniProtKB=F6XBV3	Uncharacterized protein	ISS	8930069	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01314	nck	PANTR|Ensembl=ENSPTRG00000012316|UniProtKB=H2QIH7	NCK adaptor protein 2	ISS	12874226	PubMed	PTHR44108:SF1	CYTOPLASMIC PROTEIN NCK2
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00144	Ire-1	ARATH|TAIR=AT5G24360|UniProtKB=Q93VJ2	Serine/threonine-protein kinase/endoribonuclease IRE1b	IDA	10619423	PubMed	PTHR13954:SF13	SERINE/THREONINE-PROTEIN KINASE/ENDORIBONUCLEASE IRE1B
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	IGI	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00018	EGF receptor signaling pathway	P00550	Grb2	RAT|RGD=1306884|UniProtKB=Q4KM68	GRB2-related adaptor protein	ISS	51702266	gi	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00036	Interleukin signaling pathway	P00981	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	TAS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	RAT|RGD=1307535|UniProtKB=G3V928	Protein Lrp1	ISS	11907044	PubMed	PTHR44025:SF2	PROLOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1
P00034	Integrin signalling pathway	P00927	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	ARATH|TAIR=AT4G18710|UniProtKB=Q39011	Shaggy-related protein kinase eta	TAS			PTHR24057:SF5	SHAGGY-RELATED PROTEIN KINASE ETA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MACMU|Ensembl=ENSMMUG00000014754|UniProtKB=F7G124	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF721	MYOSIN-6
P00048	PI3 kinase pathway	P01177	P110ACT	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000012036|UniProtKB=F7ALP1	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00037	Ionotropic glutamate receptor pathway	P01026	KA	RAT|RGD=71027|UniProtKB=P42264	Glutamate receptor ionotropic, kainate 3	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00048	PI3 kinase pathway	P01200	SHIP	MOUSE|MGI=MGI=1333787|UniProtKB=Q6P549	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	TAS	12145149	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	ISS	1333286	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	TAS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	IC	2372396	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	MOUSE|MGI=MGI=109482|UniProtKB=P97445	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	IDA	14507926	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00012	Cadherin signaling pathway	P00465	TCF/LEF	MONDO|Ensembl=ENSMODG00000015573|UniProtKB=F7AIP6	Uncharacterized protein (Fragment)	ISS	11266476	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00029	Huntington disease	P00807	Actin	DANRE|ZFIN=ZDB-GENE-050417-267|UniProtKB=F1QUN8	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF263	ACTIN
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01332	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	IDA	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04658	PTEN	TAKRU|Ensembl=ENSTRUG00000009851|UniProtKB=H2TJ90	Uncharacterized protein	IGI	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IGI	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00021	FGF signaling pathway	P00624	14-3-3	MOUSE|MGI=MGI=894689|UniProtKB=P62259	14-3-3 protein epsilon	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00019	Endothelin signaling pathway	P00566	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10755300	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00586	Gq	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	MOUSE|MGI=MGI=106217|UniProtKB=Q61290	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	14624853	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IGI	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00221	JNK1	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	ISS	10514528	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00012	Cadherin signaling pathway	P00474	Wnt	PANTR|Ensembl=ENSPTRG00000004892|UniProtKB=H2Q5U3	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P05916	Opioid prodynorphin pathway	P06001	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P05912	Dopamine receptor mediated signaling pathway	P05970	TH	PANTR|Ensembl=ENSPTRG00000003173|UniProtKB=H2Q2W7	Uncharacterized protein	ISS	12480184	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	IDA	94131269	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PRIPA|Gene=PPA21758|UniProtKB=H3FHL1	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF89	TUBULIN BETA-4 CHAIN
P00053	T cell activation	P01307	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00006	Apoptosis signaling pathway	P00291	MEKK1	PANTR|Ensembl=ENSPTRG00000016891|UniProtKB=H2R5K3	Uncharacterized protein	ISS	12049732	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P02784	Tyrosine biosynthesis	P03212	Chorismate mutase	NEUCR|EnsemblGenome=EFNCRG00000008062|UniProtKB=Q7S8R4	Chorismate mutase	ISS			PTHR21145:SF0	CHORISMATE MUTASE
P05913	Enkephalin release	P05974	G-Protein (i)	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IDA	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00029	Huntington disease	P00797	p53	CANLF|Ensembl=ENSCAFG00000013961|UniProtKB=F1PL57	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Ensembl=ENSGALG00000011086|UniProtKB=P68139	Actin, alpha skeletal muscle	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00034	Integrin signalling pathway	P00924	Raf	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00053	T cell activation	P01307	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	AQUAE|EnsemblGenome=aq_2045|UniProtKB=O67833	Folylpolyglutamate synthetase	ISS			PTHR11136:SF0	DIHYDROFOLATE SYNTHETASE-RELATED
P00005	Angiogenesis	P00256	PLC-gamma	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00056	VEGF signaling pathway	P01403	VEGFR-2	PANTR|Ensembl=ENSPTRG00000016069|UniProtKB=H2QPH6	Uncharacterized protein	ISS	11221852	PubMed	PTHR24416:SF45	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2
P00029	Huntington disease	P00786	ARF	XENTR|Xenbase=XB-GENE-5783083|UniProtKB=Q6DIV3	ADP-ribosylation factor-like 4A	ISS	12932731	PubMed	PTHR11711:SF139	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 4A
P00048	PI3 kinase pathway	P01177	P110ACT	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	HUMAN|HGNC=703|UniProtKB=Q92747	Actin-related protein 2/3 complex subunit 1A	ISS	12963527	gi	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	BOVIN|Ensembl=ENSBTAG00000013298|UniProtKB=A4IFJ5	Cytosolic phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	ORNAN|Ensembl=ENSOANG00000002061|UniProtKB=F7ANC6	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	TAS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00647	SHP2	MOUSE|MGI=MGI=99511|UniProtKB=P35235	Tyrosine-protein phosphatase non-receptor type 11	IGI	14525967	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01076	CAT	PANTR|Ensembl=ENSPTRG00000002489|UniProtKB=H2RAF8	Uncharacterized protein	ISS	92155737	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	DROME|FlyBase=FBgn0265434|UniProtKB=Q99323	Myosin heavy chain, non-muscle	IC			PTHR13140:SF574	MYOSIN HEAVY CHAIN, NON-MUSCLE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00049	Parkinson disease	P01227	20S proteasome	YEAST|SGD=S000004931|UniProtKB=P40302	Proteasome subunit alpha type-6	TAS	12859888	PubMed	PTHR11599:SF12	PROTEASOME SUBUNIT ALPHA TYPE-RELATED
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000024633|UniProtKB=F1MBU9	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CHICK|Ensembl=ENSGALG00000011809|UniProtKB=F1NMB0	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00021	FGF signaling pathway	P00639	Shc	PANTR|Ensembl=ENSPTRG00000021091|UniProtKB=H2QXF3	Uncharacterized protein	ISS	9507002	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P00021	FGF signaling pathway	P00642	MEK1-2	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=109248|UniProtKB=Q920H4	Muscarinic acetylcholine receptor M5	IDA			PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00012	Cadherin signaling pathway	P00470	F-actin	BOVIN|Gene=ACTB|UniProtKB=P60712	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-478663|UniProtKB=F7EG64	Protein kinase C delta type	ISS	11880265	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02724	Alanine biosynthesis	P02815	Branched chain amino acid aminotransferase	HUMAN|HGNC=977|UniProtKB=O15382	Branched-chain-amino-acid aminotransferase, mitochondrial	ISS			PTHR11825:SF39	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, MITOCHONDRIAL
P00048	PI3 kinase pathway	P01202	p85	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00021	FGF signaling pathway	P00646	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MACMU|Ensembl=ENSMMUG00000006492|UniProtKB=F7H998	Actin-related protein 2/3 complex subunit 3	ISS	12473693	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	STRPU|EnsemblGenome=SPU_006797|UniProtKB=W4XTP5	Uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00053	T cell activation	P01302	CD3 eta	BOVIN|Ensembl=ENSBTAG00000015710|UniProtKB=Q28073	T-cell surface glycoprotein CD3 epsilon chain	IGI	9886373	PubMed	PTHR10570:SF9	T-CELL SURFACE GLYCOPROTEIN CD3 EPSILON CHAIN
P00011	Blood coagulation	P00429	PN2	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	ISS	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00018	EGF receptor signaling pathway	P00557	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IGI	12660731	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00034	Integrin signalling pathway	P00941	Integrin alpha	HUMAN|HGNC=6146|UniProtKB=Q13349	Integrin alpha-D	IPI	3487386	PubMed	PTHR23220:SF19	INTEGRIN ALPHA-D
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	BOVIN|Ensembl=ENSBTAG00000021326|UniProtKB=Q8SQB1	C-C motif chemokine 20	IDA	12067311	PubMed	PTHR12015:SF108	C-C MOTIF CHEMOKINE 20
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IDA	3755548	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P02749	Leucine biosynthesis	P03000	Branched chain amino acid aminotransferase	AQUAE|EnsemblGenome=aq_1893|UniProtKB=O67733	Probable branched-chain-amino-acid aminotransferase	ISS			PTHR42743:SF4	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00005	Angiogenesis	P00223	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00203	Erk	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=96284|UniProtKB=P31387	5-hydroxytryptamine receptor 5B	IDA	12441358	PubMed	PTHR24247:SF14	5-HYDROXYTRYPTAMINE RECEPTOR 5B
P02723	Adenine and hypoxanthine salvage pathway	P02813	Inosine phosphorylase	SCHPO|PomBase=SPAC1805.16c|UniProtKB=Q9UTG1	Putative purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00036	Interleukin signaling pathway	P00975	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	20908895	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00048	PI3 kinase pathway	P01199	Galpha	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	IDA	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TAKRU|Ensembl=ENSTRUG00000005494|UniProtKB=P53483	Actin, alpha anomalous	IC	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	CANLF|Ensembl=ENSCAFG00000007357|UniProtKB=F1PPK6	Receptor protein serine/threonine kinase	ISS			PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P00021	FGF signaling pathway	P00628	JNK1-3	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00059	p53 pathway	P01480	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00023	General transcription regulation	P00660	RNA Polymerase II	CANLF|Ensembl=ENSCAFG00000001437|UniProtKB=E2RPD9	Uncharacterized protein	ISS	415387	gi	PTHR10773:SF12	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00057	Wnt signaling pathway	P01443	Phospholipase C	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04393	Ras Pathway	P04561	SRF	MONDO|Ensembl=ENSMODG00000018981|UniProtKB=F7FP88	Uncharacterized protein	ISS	15170389	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	RAT|RGD=70958|UniProtKB=P19492	Glutamate receptor 3	ISS	12941441	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000004742|UniProtKB=H2Q5K1	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P00048	PI3 kinase pathway	P01190	PDK1 ACT	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	RAT|RGD=2742|UniProtKB=P23385	Metabotropic glutamate receptor 1	IDA	12351712	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00059	p53 pathway	P04609	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	7937853	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00054	Toll receptor signaling pathway	P01375	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00005	Angiogenesis	P00194	Paxillin	BOVIN|Ensembl=ENSBTAG00000002391|UniProtKB=Q3MHZ4	Transforming growth factor beta-1-induced transcript 1 protein	ISS			PTHR24216:SF27	TRANSFORMING GROWTH FACTOR BETA-1-INDUCED TRANSCRIPT 1 PROTEIN
P05918	p38 MAPK pathway	P06020	p38delta	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	RCA	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00010	B cell activation	P00375	Calmodulin	ORYSJ|EnsemblGenome=OS05G0491100|UniProtKB=Q6F332	Calmodulin-2	ISS	7514101	PubMed	PTHR23050:SF324	CALMODULIN-2-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00053	T cell activation	P01306	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04397	p53 pathway by glucose deprivation	P04641	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00219	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00020	FAS signaling pathway	P00615	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IGI	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	9395335	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00256	PLC-gamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00322	Cytochrome C	YEAST|SGD=S000000765|UniProtKB=P00045	Cytochrome c iso-2	ISS			PTHR11961:SF12	CYTOCHROME C
P00006	Apoptosis signaling pathway	P00301	Apaf-1	HUMAN|HGNC=576|UniProtKB=O14727	Apoptotic protease-activating factor 1	IDA	14526190	PubMed	PTHR22845:SF5	APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
P00046	Oxidative stress response	P01121	MKK3/6	MACMU|Ensembl=ENSMMUG00000001051|UniProtKB=F6QNB5	Dual specificity mitogen-activated protein kinase kinase 6	RCA			PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P00046	Oxidative stress response	P01135	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ORYSJ|EnsemblGenome=OS06G0154500|UniProtKB=Q84UI5	Mitogen-activated protein kinase 1	ISS	10514528	PubMed	PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05918	p38 MAPK pathway	P06026	MEKK4	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS	9079650	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00012	Cadherin signaling pathway	P00462	Casein kinase II	ORNAN|Ensembl=ENSOANG00000012115|UniProtKB=F7F9Q9	Uncharacterized protein	ISS	10617630	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P06587	Nicotine pharmacodynamics pathway	P06595	CHRNA3	HUMAN|HGNC=1957|UniProtKB=P32297	Neuronal acetylcholine receptor subunit alpha-3	IDA	18005395	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P00053	T cell activation	P01324	rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANAL|CGD=CAL0068551|UniProtKB=Q5AAR9	Phosphatidylinositol 3-kinase	TAS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	RCA	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00012	Cadherin signaling pathway	P00470	F-actin	CRYNJ|EnsemblGenome=CNA04650|UniProtKB=Q5KP06	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00020	FAS signaling pathway	P00615	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00020	FAS signaling pathway	P00603	Pro-Caspase9	MOUSE|MGI=MGI=1277950|UniProtKB=Q8C3Q9	Caspase-9	IGI	9390557	PubMed	PTHR10454:SF157	CASPASE-9
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	ISS	8836152	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00906	Rap1	RAT|RGD=1564414|UniProtKB=Q6IML7	DnaJ homolog subfamily C member 27	ISS			PTHR24073:SF269	DNAJ HOMOLOG SUBFAMILY C MEMBER 27
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04371	5-Hydroxytryptamine biosynthesis	P04399	Tryptophan hydroxylase	DANRE|ZFIN=ZDB-GENE-040624-4|UniProtKB=Q1LUE4	Uncharacterized protein	ISS	14597720	PubMed	PTHR11473:SF16	TRYPTOPHAN 5-HYDROXYLASE 2
P05916	Opioid prodynorphin pathway	P06002	G-protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01444	Wnt	MONDO|Ensembl=ENSMODG00000010644|UniProtKB=F7D4J8	Protein Wnt (Fragment)	ISS	8717036	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00004	Alzheimer disease-presenilin pathway	P00168	E-cadherin intracellular fragment	RAT|RGD=69279|UniProtKB=Q9R0T4	Cadherin-1	IDA	11953314	PubMed	PTHR24027:SF319	CADHERIN-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Gene=OPRM1|UniProtKB=Q5IS39	Mu-type opioid receptor	ISS	11259487	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	MOUSE|MGI=MGI=106217|UniProtKB=Q61290	Voltage-dependent R-type calcium channel subunit alpha-1E	IDA	11976940	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00005	Angiogenesis	P00223	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MACMU|Ensembl=ENSMMUG00000001353|UniProtKB=F7D6T8	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00021	FGF signaling pathway	P00629	PP2A	RAT|RGD=3381|UniProtKB=P62716	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00034	Integrin signalling pathway	P00925	MEK	BOVIN|Ensembl=ENSBTAG00000012103|UniProtKB=A5PJP8	MAP2K4 protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00029	Huntington disease	P00783	Rab8	ARATH|TAIR=AT1G06400|UniProtKB=P28185	Ras-related protein RABA1a	IDA			PTHR24073:SF544	RAS-RELATED PROTEIN RABA1A
P00054	Toll receptor signaling pathway	P01345	IKKalpha	HUMAN|HGNC=1974|UniProtKB=O15111	Inhibitor of nuclear factor kappa-B kinase subunit alpha	ISS	12235208	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00030	Hypoxia response via HIF activation	P00819	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	RCA	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00010	B cell activation	P00402	Jnk	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00036	Interleukin signaling pathway	P00990	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=3025|UniProtKB=P21917	D(4) dopamine receptor	IDA	2137198	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00736	CalDAG-GEF	RAT|RGD=620476|UniProtKB=Q8R5I4	RAS guanyl-releasing protein 4	IDA	10835426	PubMed	PTHR23113:SF157	RAS GUANYL-RELEASING PROTEIN 4
P00029	Huntington disease	P00778	NMDA receptor	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	IDA	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	IPI	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01168	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01306	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	91232861	PubMed	PTHR24070:SF385	GTPASE HRAS
P00011	Blood coagulation	P00443	Fibrin polymer cross-linked	PANTR|Ensembl=ENSPTRG00000016536|UniProtKB=H2RDH7	Uncharacterized protein	ISS	223170	gi	PTHR19143:SF338	FIBRINOGEN GAMMA CHAIN
P04398	p53 pathway feedback loops 2	P04666	cyclin A	HUMAN|HGNC=1578|UniProtKB=P20248	Cyclin-A2	ISS			PTHR10177:SF69	CYCLIN-A2
P02734	Chorismate biosynthesis	P02868	Chorismate synthase	METAC|EnsemblGenome=MA_0550|UniProtKB=Q8TT87	Chorismate synthase	ISS			PTHR21085:SF0	CHORISMATE SYNTHASE
P00048	PI3 kinase pathway	P01181	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	CAEBR|Gene=CBG13820|UniProtKB=A8XIS2	Glutamine synthetase	ISS			PTHR20852:SF64	GLUTAMINE SYNTHETASE
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02723	Adenine and hypoxanthine salvage pathway	P02810	Adenine phosphoribosyl transferase	CAEBR|Gene=CBG14916|UniProtKB=A8XKZ6	Protein CBG14916	ISS			PTHR32315:SF3	ADENINE PHOSPHORIBOSYLTRANSFERASE
P00017	DNA replication	P00527	Histones	BRAFL|Gene=BRAFLDRAFT_67487|UniProtKB=C3XPT8	Uncharacterized protein	ISS	12413958	PubMed	PTHR11426:SF169	HISTONE H3
P05913	Enkephalin release	P05974	G-Protein (i)	NEUCR|EnsemblGenome=EFNCRG00000000159|UniProtKB=F5HH30	Guanine nucleotide-binding protein beta subunit	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00019	Endothelin signaling pathway	P00586	Gq	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	8836152	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00057	Wnt signaling pathway	P01438	PP2A	DANRE|ZFIN=ZDB-GENE-050417-441|UniProtKB=Q567Y8	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00023	General transcription regulation	P00660	RNA Polymerase II	SCHPO|PomBase=SPBC14C8.12|UniProtKB=Q92399	DNA-directed RNA polymerases I, II, and III subunit RPABC3	ISS	606023	OMIM	PTHR10917:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00005	Angiogenesis	P00249	PAK	HUMAN|HGNC=8590|UniProtKB=Q13153	Serine/threonine-protein kinase PAK 1	IDA	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00006	Apoptosis signaling pathway	P00302	ATF	HUMAN|HGNC=784|UniProtKB=P15336	Cyclic AMP-dependent transcription factor ATF-2	ISS	15218628	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00047	PDGF signaling pathway	P01175	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	95096035	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DICDI|dictyBase=DDB_G0283907|UniProtKB=P34099	cAMP-dependent protein kinase catalytic subunit	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IDA	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05918	p38 MAPK pathway	P06018	MNK1	MACMU|Ensembl=ENSMMUG00000020162|UniProtKB=F6TJV6	Uncharacterized protein	ISS	9155018	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	PANTR|Ensembl=ENSPTRG00000003502|UniProtKB=H2Q3E9	Uncharacterized protein	ISS	94365697	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P00056	VEGF signaling pathway	P01414	PLC-gamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00010	B cell activation	P00371	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00060	Ubiquitin proteasome pathway	P01491	E2	LEIMA|EnsemblGenome=LmjF.35.1300|UniProtKB=Q9GNC1	Probable ubiquitin-conjugating enzyme e2-17 kDa	ISS			PTHR24068:SF74	FI16911P1-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00047	PDGF signaling pathway	P01150	PKC	SCHPO|PomBase=SPBC12D12.04c|UniProtKB=P36583	Protein kinase C-like 2	ISS	93259141	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00006	Apoptosis signaling pathway	P00274	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	P01433	SIAH-1	HUMAN|HGNC=10858|UniProtKB=O43255	E3 ubiquitin-protein ligase SIAH2	IDA			PTHR10315:SF11	E3 UBIQUITIN-PROTEIN LIGASE SIAH2
P00055	Transcription regulation by bZIP transcription factor	P01395	TFIIE	BOVIN|Gene=GTF2E2|UniProtKB=Q2KJF9	General transcription factor IIE subunit 2	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS			PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01188	Gbetagamma	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00057	Wnt signaling pathway	P01444	Wnt	BOVIN|Ensembl=ENSBTAG00000016012|UniProtKB=F1N5R1	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P00019	Endothelin signaling pathway	P00586	Gq	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9441|UniProtKB=P51817	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00021	FGF signaling pathway	P00640	PI3K	CANAL|CGD=CAL0068551|UniProtKB=Q5AAR9	Phosphatidylinositol 3-kinase	IGI	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00021	FGF signaling pathway	P00628	JNK1-3	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	MACMU|Ensembl=ENSMMUG00000009607|UniProtKB=F7A586	5-hydroxytryptamine receptor 2C	ISS	8143856	PubMed	PTHR24247:SF32	5-HYDROXYTRYPTAMINE RECEPTOR 2C
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00005	Angiogenesis	P00256	PLC-gamma	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00006	Apoptosis signaling pathway	P00303	c-Jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CAEEL|WormBase=WBGene00001680|UniProtKB=Q20636	Guanine nucleotide-binding protein subunit beta-2	IC	11313908	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00034	Integrin signalling pathway	P00925	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00048	PI3 kinase pathway	P01199	Galpha	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00317	Fos	XENTR|Xenbase=XB-GENE-866811|UniProtKB=F7EI91	Uncharacterized protein (Fragment)	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	DANRE|ZFIN=ZDB-GENE-050417-352|UniProtKB=Q568M0	Related RAS viral (R-ras) oncogene homolog 2	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00005	Angiogenesis	P00223	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00648	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	3755548	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04398	p53 pathway feedback loops 2	P04665	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00021	FGF signaling pathway	P00634	MEKK1-5	HUMAN|HGNC=6856|UniProtKB=Q9Y6R4	Mitogen-activated protein kinase kinase kinase 4	IGI	9305639	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P04393	Ras Pathway	P04558	p38	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00057	Wnt signaling pathway	P01455	Smad4	XENTR|Xenbase=XB-GENE-1018193|UniProtKB=Q6DIS7	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P00034	Integrin signalling pathway	P00922	Collagen	HUMAN|HGNC=2218|UniProtKB=Q14055	Collagen alpha-2(IX) chain	IDA	10778855	PubMed	PTHR44706:SF1	COLLAGEN ALPHA-2 IX  CHAIN
P00059	p53 pathway	P04609	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00056	VEGF signaling pathway	P01422	eNOS	HUMAN|HGNC=7876|UniProtKB=P29474	Nitric oxide synthase, endothelial	IEP	22462730	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MACMU|Ensembl=ENSMMUG00000010987|UniProtKB=F7GCX9	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00029	Huntington disease	P00790	beta-Tubulin	BRAFL|Gene=BRAFLDRAFT_60807|UniProtKB=C3Y2F5	Putative uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IGI	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Ensembl=ENSGALG00000028749|UniProtKB=Q5ZMQ2	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00046	Oxidative stress response	P01131	MKP5	RAT|RGD=1560427|UniProtKB=D3ZAQ8	Protein Dusp21	ISS			PTHR10159:SF380	DUAL SPECIFICITY PHOSPHATASE 21
P00005	Angiogenesis	P00256	PLC-gamma	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000015599|UniProtKB=F1MIA2	Serine/threonine-protein kinase	ISS	11062248	PubMed	PTHR22968:SF12	SERINE/THREONINE-PROTEIN KINASE D2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00005	Angiogenesis	P00206	Wnt	PANTR|Ensembl=ENSPTRG00000012931|UniProtKB=H2QJF8	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	PANTR|Ensembl=ENSPTRG00000013577|UniProtKB=H2QKI0	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF30	MATRIX METALLOPROTEINASE-9
P00005	Angiogenesis	P00219	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00029	Huntington disease	P00800	PolyQ Htt	MACMU|Ensembl=ENSMMUG00000008392|UniProtKB=F6VQZ3	Uncharacterized protein	ISS	7620118	PubMed	PTHR10170:SF10	HUNTINGTIN
P00052	TGF-beta signaling pathway	P01286	TGFbeta	DANRE|ZFIN=ZDB-GENE-980526-388|UniProtKB=B3DI86	Bmp2a protein	TAS	9759503	PubMed	PTHR11848:SF143	BONE MORPHOGENETIC PROTEIN 2
P04392	P53 pathway feedback loops 1	G04684	Pirh-2	RAT|RGD=1359180|UniProtKB=Q5XIE4	Protein Rchy1	ISS	607680	OMIM	PTHR21319:SF20	RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00839	SHIP	MACMU|Ensembl=ENSMMUG00000010451|UniProtKB=F7CRA7	Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2	ISS	9824312	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	ORNAN|Ensembl=ENSOANG00000000818|UniProtKB=F6PLI7	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P02722	Acetate utilization	P02801	Acetate kinase	FUSNN|EnsemblGenome=FN1171|UniProtKB=Q8RED7	Acetate kinase	ISS			PTHR21060:SF11	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00589	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00005	Angiogenesis	P00193	SOS-1	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS			PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CIOIN|Ensembl=ENSCING00000007153|UniProtKB=L7N0T1	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00012	Cadherin signaling pathway	P00464	Fyn	RAT|RGD=2641|UniProtKB=Q62844	Tyrosine-protein kinase Fyn	ISS	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00018	EGF receptor signaling pathway	P00552	Ras	DICPU|Gene=DICPUDRAFT_51488|UniProtKB=F1A411	Putative uncharacterized protein rasC	ISS	8290260	PubMed	PTHR24070:SF251	RAS-LIKE PROTEIN RASC
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347742|UniProtKB=E9FZ00	Cytoplasmatic actin	ISS	14684598	PubMed	PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PANTR|Ensembl=ENSPTRG00000009762|UniProtKB=H2QE24	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	MOUSE|MGI=MGI=2443883|UniProtKB=Q8CHT0	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	IC			PTHR14516:SF3	DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE, MITOCHONDRIAL
P05915	Opioid proenkephalin pathway	P05994	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-478663|UniProtKB=F7EG64	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	RAT|RGD=628852|UniProtKB=Q02294	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	11976940	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IC	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00054	Toll receptor signaling pathway	G01550	Gene trancription	PANTR|Ensembl=ENSPTRG00000020811|UniProtKB=H2QX22	Uncharacterized protein	ISS			PTHR11691:SF43	INTERFERON BETA
P00021	FGF signaling pathway	P00643	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00048	PI3 kinase pathway	P01202	p85	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000005917|UniProtKB=F6QM53	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	BOVIN|Gene=ARRB2|UniProtKB=P32120	Beta-arrestin-2	IDA	11742073	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000003399|UniProtKB=H2Q383	Phosphoinositide-3-kinase, class 2, alpha polypeptide	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00010	B cell activation	P00385	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00047	PDGF signaling pathway	P01150	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06819	SMAD2-4	MOUSE|MGI=MGI=1859993|UniProtKB=Q9JIW5	Mothers against decapentaplegic homolog 9	RCA	9395284	PubMed	PTHR13703:SF41	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 9
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	SCHPO|PomBase=SPBC32H8.07|UniProtKB=Q10282	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	CHICK|Ensembl=ENSGALG00000007039|UniProtKB=F1NG99	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	DROME|FlyBase=FBgn0010399|UniProtKB=Q24418	Glutamate [NMDA] receptor subunit 1	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00047	PDGF signaling pathway	P01154	Ras	DICDI|dictyBase=DDB_G0292996|UniProtKB=P03967	Ras-like protein rasD	ISS	85024887	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=1565811|UniProtKB=F1M6B6	Protein Pcdh10	ISS	8120095	PubMed	PTHR24028:SF0	PROTOCADHERIN-10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	MACMU|Ensembl=ENSMMUG00000017654|UniProtKB=F6UI32	Beta-arrestin-2 isoform 1	ISS	4757780	gi	PTHR11792:SF20	BETA-ARRESTIN-2
P00036	Interleukin signaling pathway	P00990	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	12464394	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000013587|UniProtKB=F7AZ16	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF33	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-3
P00054	Toll receptor signaling pathway	P01360	IKKbeta	BOVIN|Ensembl=ENSBTAG00000007599|UniProtKB=Q95KV0	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000017355|UniProtKB=H2QRP0	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF42	PROTOCADHERIN-12
P00048	PI3 kinase pathway	P01188	Gbetagamma	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01411	Ras	DAPPU|EnsemblGenome=DAPPUDRAFT_301818|UniProtKB=E9I1I7	Putative uncharacterized protein	ISS	10684567	PubMed	PTHR24070:SF385	GTPASE HRAS
P00036	Interleukin signaling pathway	P00979	MAPKAPK2	PANTR|Ensembl=ENSPTRG00000001915|UniProtKB=H2Q104	Mitogen-activated protein kinase-activated protein kinase 2	ISS	7923354	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00006	Apoptosis signaling pathway	P00260	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	G01548	I-SMAD	HUMAN|HGNC=6772|UniProtKB=O43541	Mothers against decapentaplegic homolog 6	IGI	9335505	PubMed	PTHR13703:SF28	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 6
P04393	Ras Pathway	P04542	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00203	Erk	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00297	NFkappaB	MACMU|Ensembl=ENSMMUG00000014153|UniProtKB=F7BV28	Uncharacterized protein	ISS			PTHR24169:SF18	TRANSCRIPTION FACTOR RELB
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	12810719	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00019	Endothelin signaling pathway	P00583	cPLA2	MACMU|Ensembl=ENSMMUG00000021423|UniProtKB=F7EEZ1	Phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00941	Integrin alpha	MOUSE|MGI=MGI=96609|UniProtKB=Q9QXH4	Integrin alpha-X	IPI	3487386	PubMed	PTHR23220:SF118	INTEGRIN ALPHA-X
P00053	T cell activation	P01311	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IDA	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01234	GRK	CAEEL|WormBase=WBGene00001709|UniProtKB=Q09639	G protein-coupled receptor kinase 2	IDA	10852916	PubMed	PTHR24355:SF18	PROTEIN-SERINE/THREONINE KINASE
P00005	Angiogenesis	P00205	GAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	8262392	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	RAT|RGD=1311791|UniProtKB=Q4KLF8	Actin-related protein 2/3 complex subunit 5	ISS	12932731	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00012	Cadherin signaling pathway	P00474	Wnt	BOVIN|Ensembl=ENSBTAG00000013990|UniProtKB=F1MN70	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=1354946|UniProtKB=Q61532	Mitogen-activated protein kinase 6	IC	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	RAT|RGD=69079|UniProtKB=M0R9D3	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=16265|UniProtKB=Q9H1J7	Protein Wnt-5b	TAS	8717036	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00046	Oxidative stress response	P01131	MKP5	RAT|RGD=1565535|UniProtKB=Q2YDV1	Dual specificity protein phosphatase	ISS			PTHR10159:SF388	DUAL SPECIFICITY PROTEIN PHOSPHATASE 9
P00009	Axon guidance mediated by netrin	P00363	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00543	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	21186066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00021	FGF signaling pathway	P00627	ERK1-2	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01437	TCF	MOUSE|MGI=MGI=1202879|UniProtKB=Q924A0	Transcription factor 7-like 2	IDA	9118222	PubMed	PTHR10373:SF32	TRANSCRIPTION FACTOR 7-LIKE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02772	Pyruvate metabolism	P03133	Pyruvate Dehydrogenase	MOUSE|MGI=MGI=97533|UniProtKB=P35487	Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial	RCA			PTHR11516:SF23	PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA, TESTIS-SPECIFIC FORM, MITOCHONDRIAL
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00566	ERK	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=3765|UniProtKB=P30938	Somatostatin receptor type 5	IDA	12562507	PubMed	PTHR24229:SF20	SOMATOSTATIN RECEPTOR TYPE 5
P00034	Integrin signalling pathway	P00931	Integrin beta	BOVIN|Ensembl=ENSBTAG00000003709|UniProtKB=F1MVW3	Integrin beta	ISS	3487386	PubMed	PTHR10082:SF9	INTEGRIN BETA-8
P00057	Wnt signaling pathway	P01443	Phospholipase C	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DROME|FlyBase=FBgn0000489|UniProtKB=P16912	Protein kinase DC2	IC	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00053	T cell activation	P01294	NFAT	HUMAN|HGNC=7776|UniProtKB=Q13469	Nuclear factor of activated T-cells, cytoplasmic 2	IGI	9462517	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00029	Huntington disease	P00797	p53	HUMAN|HGNC=13760|UniProtKB=Q96F07	Cytoplasmic FMR1-interacting protein 2	TAS			PTHR12195:SF1	CYTOPLASMIC FMR1-INTERACTING PROTEIN 2
P05915	Opioid proenkephalin pathway	P05994	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	DROME|FlyBase=FBgn0001961|UniProtKB=O97182	Actin related complex p41 subunit	ISS	12963527	gi	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05977	G-Protein (s)	HUMAN|HGNC=19663|UniProtKB=Q9UBI6	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	RCA	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	PANTR|Ensembl=ENSPTRG00000010931|UniProtKB=H2R650	Uncharacterized protein	ISS	15226293	PubMed	PTHR13715:SF15	RYANODINE RECEPTOR 1
P00048	PI3 kinase pathway	P01192	p110	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01312	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00107	kinesin	MOUSE|MGI=MGI=107978|UniProtKB=O88447	Kinesin light chain 1	ISS	11740561	PubMed	PTHR19959:SF203	KINESIN LIGHT CHAIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DICDI|dictyBase=DDB_G0280975|UniProtKB=Q23862	Rho-related protein racE	ISS			PTHR24072:SF143	RHO-RELATED PROTEIN RACE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	TAS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00018	EGF receptor signaling pathway	P00545	JNK1-3	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00056	VEGF signaling pathway	P01423	p38MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P06210	Activin beta signaling pathway	P06231	BABO	DROME|FlyBase=FBgn0011300|UniProtKB=A1Z7L8	Receptor protein serine/threonine kinase	IEA	9395284	PubMed	PTHR23255:SF71	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04397	p53 pathway by glucose deprivation	P04637	4E-BP1	BOVIN|Ensembl=ENSBTAG00000027654|UniProtKB=Q0P5A7	Eukaryotic translation initiation factor 4E-binding protein 1	ISS	12820960	PubMed	PTHR12669:SF14	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05994	G-protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00643	Raf-1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01455	Smad4	BOVIN|Gene=SMAD4|UniProtKB=Q1HE26	Mothers against decapentaplegic homolog 4	ISS	10693808	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P00006	Apoptosis signaling pathway	P00261	Bok	HUMAN|HGNC=1087|UniProtKB=Q9UMX3	Bcl-2-related ovarian killer protein	IDA	9356461	PubMed	PTHR11256:SF48	BCL-2-RELATED OVARIAN KILLER PROTEIN
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00022	General transcription by RNA polymerase I	P00657	TBP	BOVIN|Ensembl=ENSBTAG00000035370|UniProtKB=Q32LB1	TATA box-binding protein-like protein 1	ISS	600075	OMIM	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	PANTR|Ensembl=ENSPTRG00000004718|UniProtKB=H2Q5I0	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04395	Vasopressin synthesis	P04594	Neurophysin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00021	FGF signaling pathway	P00647	SHP2	RAT|RGD=620660|UniProtKB=P81718	Tyrosine-protein phosphatase non-receptor type 6	ISS	14525967	PubMed	PTHR19134:SF65	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 6
P04398	p53 pathway feedback loops 2	P04657	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00029	Huntington disease	P00790	beta-Tubulin	CHICK|Ensembl=ENSGALG00000008586|UniProtKB=F1NYB1	Uncharacterized protein	TAS	12932731	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00005	Angiogenesis	P00236	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	G01531	BDNF	PANTR|Ensembl=ENSPTRG00000028696|UniProtKB=Q5IS78	Brain-derived neurotrophic factor	ISS	11408619	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8972|UniProtKB=O00750	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00048	PI3 kinase pathway	P01202	p85	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00048	PI3 kinase pathway	P01177	P110ACT	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00010	B cell activation	P00379	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CHICK|Ensembl=ENSGALG00000012511|UniProtKB=F1NCH1	Uncharacterized protein	ISS			PTHR11824:SF7	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00477	GSK3beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	20010089	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00048	PI3 kinase pathway	P01192	p110	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00807	Actin	XENTR|Xenbase=XB-GENE-490883|UniProtKB=Q6NVA9	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	DANRE|ZFIN=ZDB-GENE-020503-1|UniProtKB=Q1LWJ4	Tyrosine-protein kinase receptor	ISS	249616	gi	PTHR24416:SF498	TYROSINE-PROTEIN KINASE RECEPTOR
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00054	Toll receptor signaling pathway	P01381	Ubc13	CANLF|Ensembl=ENSCAFG00000006177|UniProtKB=F1PYX5	Uncharacterized protein	ISS			PTHR43902:SF2	UBIQUITIN-CONJUGATING ENZYME E2 N
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	NEUCR|EnsemblGenome=EFNCRG00000006002|UniProtKB=Q7SBR2	Phosphoinositide phospholipase C	ISS			PTHR10336:SF82	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00540	MKK3,6	RAT|RGD=1306620|UniProtKB=B1H230	Map2k3 protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	TAS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IDA	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MOUSE|MGI=MGI=87905|UniProtKB=P68033	Actin, alpha cardiac muscle 1	IC	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	XENTR|Xenbase=XB-GENE-484248|UniProtKB=F7BH92	Serine/threonine-protein kinase receptor (Fragment)	ISS	9395284	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	HUMAN|HGNC=8590|UniProtKB=Q13153	Serine/threonine-protein kinase PAK 1	ISS	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00029	Huntington disease	P00790	beta-Tubulin	PHYPA|Gene=PHYPADRAFT_121199|UniProtKB=A9RY37	Predicted protein	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P05916	Opioid prodynorphin pathway	P06001	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00005	Angiogenesis	P00221	JNK1	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00025	Hedgehog signaling pathway	P00683	Slimb	RAT|RGD=1309121|UniProtKB=A0A0G2JVE0	Protein Fbxw11	ISS	10074433	PubMed	PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05918	p38 MAPK pathway	P06020	p38delta	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	RCA	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	DANRE|ZFIN=ZDB-GENE-050417-59|UniProtKB=Q15KE4	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00047	PDGF signaling pathway	P01159	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00030	Hypoxia response via HIF activation	P00823	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	129387	gi	PTHR10048:SF14	PI-3 KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MACMU|Ensembl=ENSMMUG00000001661|UniProtKB=F7GR69	Uncharacterized protein	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00012	Cadherin signaling pathway	P00468	Src	MONDO|Ensembl=ENSMODG00000000247|UniProtKB=F6WR53	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00047	PDGF signaling pathway	P01143	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	11790551	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	RCA	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MOUSE|MGI=MGI=99842|UniProtKB=Q02284	5-hydroxytryptamine receptor 1F	ISS	1608964	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00034	Integrin signalling pathway	P00936	PI3K	XENTR|Xenbase=XB-GENE-6067221|UniProtKB=F6Z0J4	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ORNAN|Ensembl=ENSOANG00000007405|UniProtKB=F7CIV4	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00729	Goalpha	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	IDA	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P05918	p38 MAPK pathway	P06020	p38delta	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	RCA	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00006	Apoptosis signaling pathway	P00269	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01192	p110	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	MOUSE|MGI=MGI=1926879|UniProtKB=Q9EQH4	Transcription initiation factor TFIID subunit 8	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00036	Interleukin signaling pathway	P00967	c-fos	CANLF|Ensembl=ENSCAFG00000017040|UniProtKB=E2QYK5	Uncharacterized protein	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=17175|UniProtKB=Q9P212	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	7822322	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00046	Oxidative stress response	P01136	Elk-1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	TAS	11151091	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00029	Huntington disease	P00776	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	3136397	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05734	Synaptic vesicle trafficking	P05774	NSF	MOUSE|MGI=MGI=104560|UniProtKB=P46460	Vesicle-fusing ATPase	TAS	11348590	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00021	FGF signaling pathway	P00643	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05915	Opioid proenkephalin pathway	P05994	G-protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	ISS	12488551	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	CHICK|Ensembl=ENSGALG00000017242|UniProtKB=Q9IA05	Frizzled-4	TAS	11212302	PubMed	PTHR11309:SF23	FRIZZLED-4
P00021	FGF signaling pathway	P00637	MKK4,7	MONDO|Ensembl=ENSMODG00000008266|UniProtKB=F6Z879	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P02775	Salvage pyrimidine ribonucleotides	P03149	Cytidine kinase	MOUSE|MGI=MGI=98904|UniProtKB=P52623	Uridine-cytidine kinase 1	ISS			PTHR10285:SF66	URIDINE-CYTIDINE KINASE 1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	12805548	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00057	Wnt signaling pathway	P01457	GBeta	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00006	Apoptosis signaling pathway	P00269	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00267	MADD	MACMU|Ensembl=ENSMMUG00000015602|UniProtKB=F6T6E0	Uncharacterized protein	ISS	9115275	PubMed	PTHR13008:SF7	MAP KINASE-ACTIVATING DEATH DOMAIN PROTEIN
P06959	CCKR signaling map	P07075	MEF2B	HUMAN|HGNC=6995|UniProtKB=Q02080	Myocyte-specific enhancer factor 2B	RCA		PubMed	PTHR11945:SF335	MYOCYTE-SPECIFIC ENHANCER FACTOR 2B-RELATED
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	BOVIN|Ensembl=ENSBTAG00000031500|UniProtKB=Q3SZ20	Serine hydroxymethyltransferase, mitochondrial	ISS			PTHR11680:SF17	SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	RAT|RGD=2344|UniProtKB=P08485	Muscarinic acetylcholine receptor M4	TAS	10069496	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00053	T cell activation	P01335	jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04393	Ras Pathway	P04556	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IDA	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01435	SWI/SNF	BOVIN|Ensembl=ENSBTAG00000010380|UniProtKB=E1BAN8	Uncharacterized protein	ISS	11532957	PubMed	PTHR10799:SF868	DNA HELICASE INO80
P00021	FGF signaling pathway	P00636	FGFR1-4	DANRE|ZFIN=ZDB-GENE-980526-255|UniProtKB=Q90Z00	Fibroblast growth factor receptor 1-A	ISS			PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00018	EGF receptor signaling pathway	P00546	GAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	227170	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05730	Endogenous cannabinoid signaling	P05748	mGluR	MACMU|Ensembl=ENSMMUG00000016428|UniProtKB=F7GU00	Metabotropic glutamate receptor 1 isoform alpha	ISS	14614461	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	MOUSE|MGI=MGI=1321161|UniProtKB=P62715	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00036	Interleukin signaling pathway	P00965	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00055	Transcription regulation by bZIP transcription factor	P01390	TFIIA complex	SCHPO|PomBase=SPCC553.11c|UniProtKB=O74948	Transcription initiation factor IIA subunit 2	ISS			PTHR10966:SF0	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	ORNAN|Ensembl=ENSOANG00000006877|UniProtKB=F7CQF2	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	IDA	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_114976|UniProtKB=C3YP58	Putative uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02783	Tryptophan biosynthesis	P03209	Anthranilate phosphoribosyl transferase	GLOVI|Gene=BAC88824|UniProtKB=Q7NM84	Anthranilate synthase component II	ISS			PTHR43418:SF4	MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	RAT|RGD=620467|UniProtKB=Q9JHU0	Dihydropyrimidinase-related protein 5	IPI	10851247	PubMed	PTHR11647:SF58	DIHYDROPYRIMIDINASE-RELATED PROTEIN 5
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00021	FGF signaling pathway	P00631	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	8051109	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04393	Ras Pathway	P04542	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04393	Ras Pathway	P04557	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00029	Huntington disease	P00805	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00001	Adrenaline and noradrenaline biosynthesis	P00062	TH	TAKRU|Ensembl=ENSTRUG00000009267|UniProtKB=A0JGX6	Tyrosine 3-monooxygenase	ISS	12814656	PubMed	PTHR11473:SF34	TYROSINE HYDROXYLASE
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IGI	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00054	Toll receptor signaling pathway	P01343	IRAK1	MOUSE|MGI=MGI=107420|UniProtKB=Q62406	Interleukin-1 receptor-associated kinase 1	IDA	96279287	PubMed	PTHR24419:SF1	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MOUSE|MGI=MGI=1196627|UniProtKB=Q9R1C8	5-hydroxytryptamine receptor 6	IDA	12441358	PubMed	PTHR24247:SF114	5-HYDROXYTRYPTAMINE RECEPTOR 6
P00058	mRNA splicing	P01475	U2AF65	HUMAN|HGNC=12456|UniProtKB=Q15695	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1	ISS			PTHR12620:SF29	U2 SMALL NUCLEAR RIBONUCLEOPROTEIN AUXILIARY FACTOR 35 KDA SUBUNIT-RELATED PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00047	PDGF signaling pathway	P01154	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00029	Huntington disease	P00807	Actin	CIOIN|Ensembl=ENSCING00000007153|UniProtKB=L7N0T1	Uncharacterized protein	ISS			PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00766	Htt	RAT|RGD=68337|UniProtKB=P51111	Huntingtin	IDA	8268927	PubMed	PTHR10170:SF10	HUNTINGTIN
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	HUMAN|HGNC=10934|UniProtKB=P54219	Chromaffin granule amine transporter	ISS	11443533	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00566	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	CANLF|Ensembl=ENSCAFG00000012934|UniProtKB=F1P750	Uncharacterized protein	ISS	9006902	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04393	Ras Pathway	P04567	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	METAC|EnsemblGenome=MA_0636|UniProtKB=Q8TT07	Aspartate aminotransferase	ISS			PTHR11751:SF439	SUBFAMILY NOT NAMED
P00049	Parkinson disease	P01229	Pael-R	RAT|RGD=628835|UniProtKB=Q9QYC5	Prosaposin receptor GPR37L1	IDA			PTHR24243:SF33	PROSAPOSIN RECEPTOR GPR37L1
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	TAS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00046	Oxidative stress response	P01129	JNK1/2	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00010	B cell activation	P00371	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MOUSE|MGI=MGI=95816|UniProtKB=B1AS29	Glutamate receptor ionotropic, kainate 3	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MACMU|Ensembl=ENSMMUG00000022111|UniProtKB=F7H7W3	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	HALSA|EnsemblGenome=VNG_1301G|UniProtKB=Q9HQ70	Cysteine synthase	ISS			PTHR10314:SF159	CYSTEINE SYNTHASE A
P00029	Huntington disease	P00779	TBP	CAEEL|WormBase=WBGene00006542|UniProtKB=P32085	TATA-box-binding protein	IPI	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P05915	Opioid proenkephalin pathway	P05994	G-protein	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00021	FGF signaling pathway	P00634	MEKK1-5	BOVIN|Ensembl=ENSBTAG00000013790|UniProtKB=E1B847	Uncharacterized protein	ISS	8940199	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00005	Angiogenesis	P00219	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	TRIVA|Gene=TVAG_489800|UniProtKB=A2FQ69	Adenylate kinase	ISS			PTHR23359:SF22	GTP:AMP PHOSPHOTRANSFERASE, MITOCHONDRIAL
P00012	Cadherin signaling pathway	P00477	GSK3beta	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00021	FGF signaling pathway	P00648	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	HUMAN|HGNC=4474|UniProtKB=P46092	C-C chemokine receptor type 10	IDA	11821900	PubMed	PTHR10489:SF773	C-C CHEMOKINE RECEPTOR TYPE 10
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	ISS	10974003	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2743|UniProtKB=P31421	Metabotropic glutamate receptor 2	IDA	20012997	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	HUMAN|HGNC=21172|UniProtKB=Q7Z6V5	tRNA-specific adenosine deaminase 2	ISS			PTHR11079:SF92	TRNA-SPECIFIC ADENOSINE DEAMINASE 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	RAT|RGD=2917|UniProtKB=P15127	Insulin receptor	ISS	249616	gi	PTHR24416:SF402	INSULIN RECEPTOR
P06959	CCKR signaling map	G07262	HDC	HUMAN|HGNC=4855|UniProtKB=P19113	Histidine decarboxylase	RCA	12372397	PubMed	PTHR11999:SF68	HISTIDINE DECARBOXYLASE
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00011	Blood coagulation	P00418	Fibrin monomer	MACMU|Ensembl=ENSMMUG00000021302|UniProtKB=F6UZ87	Uncharacterized protein	ISS	6575700	PubMed	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00034	Integrin signalling pathway	P00907	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00642	MEK1-2	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IGI	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05731	GABA-B receptor II signaling	P05754	Ggamma	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00053	T cell activation	P01311	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06758	DRD2	MOUSE|MGI=MGI=94924|UniProtKB=P61168	D(2) dopamine receptor	RCA	11248120	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00053	T cell activation	P01322	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00011	Blood coagulation	P00412	PS	HUMAN|HGNC=9456|UniProtKB=P07225	Vitamin K-dependent protein S	IDA	87092407	PubMed	PTHR24040:SF0	VITAMIN K-DEPENDENT PROTEIN S
P00009	Axon guidance mediated by netrin	P00357	Netrin	PANTR|Ensembl=ENSPTRG00000007651|UniProtKB=H2QAD5	Uncharacterized protein	ISS			PTHR10574:SF292	NETRIN-3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	RCA	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01336	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-8225|UniProtKB=Q7SZZ5	Uncharacterized protein	ISS			PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05912	Dopamine receptor mediated signaling pathway	P05957	K+ channel	HUMAN|HGNC=6283|UniProtKB=Q9NPC2	Potassium channel subfamily K member 9	ISS	15282272	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00021	FGF signaling pathway	P00642	MEK1-2	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02742	Tetrahydrofolate biosynthesis	P02945	Dihydropteroate synthase	AQUAE|EnsemblGenome=aq_1468|UniProtKB=O67448	Dihydropteroate synthase	ISS			PTHR20941:SF1	FOLIC ACID SYNTHESIS PROTEIN FOL1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000006307|UniProtKB=H2SSM1	Uncharacterized protein	ISS			PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02746	Heme biosynthesis	P02973	Uroporphyrinogen methyltransferase	LEPIN|EnsemblGenome=LA_4218|UniProtKB=Q8EYJ6	Uroporphyrin-III C-methyltransferase	ISS			PTHR21091:SF16	SIROHEME SYNTHASE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MACMU|Ensembl=ENSMMUG00000019443|UniProtKB=F6R0Q4	Syntaxin-11	ISS	11067767	PubMed	PTHR19957:SF30	SYNTAXIN-11
P00005	Angiogenesis	P00235	c-Fos	XENTR|Xenbase=XB-GENE-866811|UniProtKB=F7EI91	Uncharacterized protein (Fragment)	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00048	PI3 kinase pathway	P01202	p85	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P05730	Endogenous cannabinoid signaling	P05748	mGluR	HUMAN|HGNC=4593|UniProtKB=Q13255	Metabotropic glutamate receptor 1	ISS	14614461	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	BOVIN|Ensembl=ENSBTAG00000033153|UniProtKB=F1MG21	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	MOUSE|MGI=MGI=97453|UniProtKB=P35454	Oxytocin-neurophysin 1	ISS	9756087	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P02721	ATP synthesis	P02791	F1 alpha	PANTR|Ensembl=ENSPTRG00000009991|UniProtKB=A5A6H5	ATP synthase subunit alpha, mitochondrial	ISS	11479684	PubMed	PTHR43089:SF4	ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL
P00018	EGF receptor signaling pathway	P00560	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00078	Alpha1A/1B/1C	MACMU|Ensembl=ENSMMUG00000011842|UniProtKB=G7NAM7	Uncharacterized protein	ISS	11781138	PubMed	PTHR24248:SF26	ALPHA-2B ADRENERGIC RECEPTOR
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=17175|UniProtKB=Q9P212	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	15611108	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P02738	De novo purine biosynthesis	P02907	dADP kinase	DROME|FlyBase=FBgn0000150|UniProtKB=P08879	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IGI	3755548	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00005	Angiogenesis	P00219	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00005	Angiogenesis	P00196	VRAP	MOUSE|MGI=MGI=1351596|UniProtKB=Q9QXK9	SH2 domain-containing protein 2A	IDA	10692392	PubMed	PTHR14388:SF9	SH2 DOMAIN-CONTAINING PROTEIN 2A
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01312	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04393	Ras Pathway	P04567	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00034	Integrin signalling pathway	P00924	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00056	VEGF signaling pathway	P01423	p38MAPK	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00046	Oxidative stress response	P01129	JNK1/2	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00059	p53 pathway	P04616	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	IDA	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00034	Integrin signalling pathway	P00921	PINCH	MONDO|Ensembl=ENSMODG00000018662|UniProtKB=F7AFB2	Uncharacterized protein	ISS	10022929	PubMed	PTHR24210:SF10	LIM AND SENESCENT CELL ANTIGEN-LIKE-CONTAINING DOMAIN PROTEIN 2
P00037	Ionotropic glutamate receptor pathway	P01026	KA	RAT|RGD=2734|UniProtKB=Q01812	Glutamate receptor ionotropic, kainate 4	ISS	11319238	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=5291|UniProtKB=P28566	5-hydroxytryptamine receptor 1E	IDA	11701344	PubMed	PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	ORYSJ|EnsemblGenome=OS10G0510000|UniProtKB=A3C6D7	Actin-2	IC	14684598	PubMed	PTHR11937:SF252	SUBFAMILY NOT NAMED
P04395	Vasopressin synthesis	P04589	Signal Peptidase	HUMAN|HGNC=23400|UniProtKB=Q9BY50	Signal peptidase complex catalytic subunit SEC11C	IC	2092035	PubMed	PTHR10806:SF12	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11C
P00034	Integrin signalling pathway	P00925	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	SULSO|EnsemblGenome=SSO0641|UniProtKB=Q59969	Carbamoyl-phosphate synthase large chain	ISS			PTHR11405:SF5	CAD PROTEIN
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	MOUSE|MGI=MGI=102522|UniProtKB=Q8R3Z5	Voltage-dependent L-type calcium channel subunit beta-1	ISS	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00021	FGF signaling pathway	P00645	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	IPI	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	TAKRU|Ensembl=ENSTRUG00000009851|UniProtKB=H2TJ90	Uncharacterized protein	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00010	B cell activation	P00373	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	HUMAN|HGNC=1957|UniProtKB=P32297	Neuronal acetylcholine receptor subunit alpha-3	IC	85270494	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	HUMAN|HGNC=17300|UniProtKB=Q7Z7C8	Transcription initiation factor TFIID subunit 8	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00010	B cell activation	P00383	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	DROME|FlyBase=FBgn0004118|UniProtKB=P25162	Acetylcholine receptor subunit beta-like 2	ISS			PTHR18945:SF505	ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 2
P00059	p53 pathway	P01485	p53	RAT|RGD=620863|UniProtKB=Q9JJP6	Tumor protein 63	TAS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	DANRE|ZFIN=ZDB-GENE-980605-30|UniProtKB=Q9YHE8	Transcription factor 7-like 1-A	IEP	12356903	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ORYSJ|EnsemblGenome=OS06G0154500|UniProtKB=Q84UI5	Mitogen-activated protein kinase 1	ISS	12787066	PubMed	PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P00005	Angiogenesis	P00219	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00005	Angiogenesis	P00227	PLA2	RAT|RGD=67366|UniProtKB=P50393	Cytosolic phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00046	Oxidative stress response	P01137	MNK1/2	MOUSE|MGI=MGI=894316|UniProtKB=O08605	MAP kinase-interacting serine/threonine-protein kinase 1	IDA	9155017	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00012	Cadherin signaling pathway	P00475	Frizzled	BOVIN|Ensembl=ENSBTAG00000020590|UniProtKB=G3N2W8	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF34	FRIZZLED-2
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	IDA	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00046	Oxidative stress response	P01129	JNK1/2	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	TAS	10207617	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00036	Interleukin signaling pathway	P00990	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	HUMAN|HGNC=175|UniProtKB=P37023	Serine/threonine-protein kinase receptor R3	TAS	9395284	PubMed	PTHR23255:SF66	SERINE/THREONINE-PROTEIN KINASE RECEPTOR R3
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00752	cGMP-gated ion channel	HUMAN|HGNC=2150|UniProtKB=Q16281	Cyclic nucleotide-gated cation channel alpha-3	IDA	12432397	PubMed	PTHR10217:SF390	CYCLIC NUCLEOTIDE-GATED CATION CHANNEL ALPHA-3
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00056	VEGF signaling pathway	P01425	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	94179345	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00059	p53 pathway	G01579	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00007	Axon guidance mediated by semaphorins	P00330	CRAM	BOVIN|Ensembl=ENSBTAG00000018576|UniProtKB=A8E641	DPYSL5 protein	ISS	11034345	PubMed	PTHR11647:SF58	DIHYDROPYRIMIDINASE-RELATED PROTEIN 5
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00057	Wnt signaling pathway	P01456	beta-arrestin	BOVIN|Ensembl=ENSBTAG00000021480|UniProtKB=P08168	S-arrestin	IC	10206946	PubMed	PTHR11792:SF15	S-ARRESTIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P06587	Nicotine pharmacodynamics pathway	P06608	DDC	HUMAN|HGNC=2719|UniProtKB=P20711	Aromatic-L-amino-acid decarboxylase	TAS	90339966	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06794	MAP2K1/2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	RCA	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P06959	CCKR signaling map	P07134	PKCdelta	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	RCA	15117677	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00059	p53 pathway	P04630	PP2A	MONDO|Ensembl=ENSMODG00000014177|UniProtKB=F6U7A6	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	DROME|FlyBase=FBgn0001139|UniProtKB=P16371	Protein groucho	IDA	9783586	PubMed	PTHR10814:SF26	PROTEIN GROUCHO
P00049	Parkinson disease	P01230	Src kinase	MONDO|Ensembl=ENSMODG00000017905|UniProtKB=F7FG65	Tyrosine-protein kinase	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00053	T cell activation	P01319	PAK	HUMAN|HGNC=8590|UniProtKB=Q13153	Serine/threonine-protein kinase PAK 1	IDA	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P02755	Methylmalonyl pathway	P03032	Methylmalonyl-CoA epimerase	DICDI|dictyBase=DDB_G0275181|UniProtKB=Q553V2	Methylmalonyl-CoA epimerase, mitochondrial	ISS			PTHR43048:SF3	METHYLMALONYL-COA EPIMERASE, MITOCHONDRIAL
P00023	General transcription regulation	P00666	TFIIE	PANTR|Ensembl=ENSPTRG00000022529|UniProtKB=H2QZJ1	Transcription initiation factor IIE subunit beta	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02926	Aspartate carbamoyltransferase	ECOLI|EcoGene=EG10805|UniProtKB=P0A786	Aspartate carbamoyltransferase catalytic chain	ISS			PTHR11405:SF16	ASPARTATE CARBAMOYLTRANSFERASE, CHLOROPLASTIC
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	DROME|FlyBase=FBgn0024846|UniProtKB=O61443	Mitogen-activated protein kinase 14B	ISS	11274345	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	HUMAN|HGNC=1609|UniProtKB=P51685	C-C chemokine receptor type 8	TAS	12009564	PubMed	PTHR10489:SF627	C-C CHEMOKINE RECEPTOR TYPE 8
P00021	FGF signaling pathway	P00648	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	1170702	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00005	Angiogenesis	P00206	Wnt	RAT|RGD=621346|UniProtKB=Q2IBD1	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P02730	Asparagine and aspartate biosynthesis	P02853	Asparagine synthetase	MYCTU|EnsemblGenome=Rv2201|UniProtKB=P9WN33	Putative asparagine synthetase [glutamine-hydrolyzing]	ISS			PTHR43284:SF2	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00260	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IDA	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00057	Wnt signaling pathway	P01444	Wnt	DROME|FlyBase=FBgn0010453|UniProtKB=P40589	Protein Wnt-4	ISS	11266476	PubMed	PTHR12027:SF102	PROTEIN WNT-4
P04393	Ras Pathway	P04557	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	IDA	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00053	T cell activation	P01336	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00968	Ikk	HUMAN|HGNC=5960|UniProtKB=O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	IDA	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00059	p53 pathway	P04609	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P05915	Opioid proenkephalin pathway	P05994	G-protein	MOUSE|MGI=MGI=101848|UniProtKB=P62881	Guanine nucleotide-binding protein subunit beta-5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P02772	Pyruvate metabolism	P03140	Pyruvate Carboxylase	MOUSE|MGI=MGI=97520|UniProtKB=Q05920	Pyruvate carboxylase, mitochondrial	ISS	200246	gi	PTHR43778:SF2	PYRUVATE CARBOXYLASE, MITOCHONDRIAL
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	RCA	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01461	FrzB	XENTR|Xenbase=XB-GENE-482077|UniProtKB=F6ZIJ4	Uncharacterized protein (Fragment)	ISS	10960783	PubMed	PTHR11309:SF11	SIZZLED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00830	Lipoxygenase	PANTR|Ensembl=ENSPTRG00000005757|UniProtKB=H2Q7D6	Uncharacterized protein	ISS	11937571	PubMed	PTHR10250:SF2	ARACHIDONATE 5-LIPOXYGENASE-ACTIVATING PROTEIN
P00053	T cell activation	P01318	PKC-theta	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IGI	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00983	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00005	Angiogenesis	P00188	Ets	MOUSE|MGI=MGI=95455|UniProtKB=P27577	Protein C-ets-1	ISS	15298723	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=3234|UniProtKB=P33535	Mu-type opioid receptor	IDA	11259487	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00056	VEGF signaling pathway	P01411	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00052	TGF-beta signaling pathway	P01275	P38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	TAS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00010	B cell activation	P00379	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MOUSE|MGI=MGI=95823|UniProtKB=Q03391	Glutamate receptor ionotropic, NMDA 2D	IC	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2D.html	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	15572354	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05913	Enkephalin release	P05977	G-Protein (s)	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00590	IP3 R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	BOVIN|Ensembl=ENSBTAG00000047202|UniProtKB=G3N3K3	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00053	T cell activation	P01311	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IDA	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00559	MEK1-2	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00054	Toll receptor signaling pathway	P01375	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04373	5HT1 type receptor mediated signaling pathway	P04409	5HT transporter	BOVIN|Gene=SLC6A4|UniProtKB=Q9XT49	Sodium-dependent serotonin transporter	IEA	14653308	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P04393	Ras Pathway	P04555	PDK	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	IDA	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	IC	9166716	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04393	Ras Pathway	P04546	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	IDA	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00019	Endothelin signaling pathway	P00568	PKC	DANRE|ZFIN=ZDB-GENE-030131-6503|UniProtKB=Q7ZUC5	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF297	PROTEIN KINASE C DELTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05938	RhoA	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	ISS	12039949	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-040426-2427|UniProtKB=F1Q6C0	Uncharacterized protein (Fragment)	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00021	FGF signaling pathway	P00648	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01440	Cadherin	CANLF|Ensembl=ENSCAFG00000003758|UniProtKB=F1PD90	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF9	PROTOCADHERIN-18
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00034	Integrin signalling pathway	P00949	Shc	MOUSE|MGI=MGI=98296|UniProtKB=P98083	SHC-transforming protein 1	IPI	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	TAKRU|Ensembl=ENSTRUG00000016241|UniProtKB=H2UX35	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF305	PROTEIN KINASE C
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	NAS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IDA	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00019	Endothelin signaling pathway	P00580	ET-RA/B	XENTR|Xenbase=XB-GENE-1219159|UniProtKB=F7A767	Uncharacterized protein	ISS			PTHR24243:SF103	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00628	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	PANTR|Ensembl=ENSPTRG00000014725|UniProtKB=H2QM91	Uncharacterized protein	ISS	11698495	PubMed	PTHR10489:SF608	C-C CHEMOKINE RECEPTOR TYPE 4
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	10747026	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00018	EGF receptor signaling pathway	P00565	PKC	CANAL|CGD=CAL0003231|UniProtKB=Q5ANK2	Protein kinase C	IGI	96408767	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	ARATH|TAIR=AT1G59580|UniProtKB=Q39022	Mitogen-activated protein kinase 2	TAS			PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	PANTR|Ensembl=ENSPTRG00000015241|UniProtKB=Q5IS72	D(3) dopamine receptor	ISS	11248120	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00060	Ubiquitin proteasome pathway	P01491	E2	XENTR|Xenbase=XB-GENE-972278|UniProtKB=Q28EY6	Ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)	ISS			PTHR24068:SF120	UBIQUITIN-CONJUGATING ENZYME E2D 2  UBC4/5 HOMOLOG, YEAST
P04398	p53 pathway feedback loops 2	P04657	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00819	AKT	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	IC	12089061	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05974	G-Protein (i)	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00053	T cell activation	P01297	MEKK	HUMAN|HGNC=6848|UniProtKB=Q13233	Mitogen-activated protein kinase kinase kinase 1	RCA	12049732	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	PANTR|Ensembl=ENSPTRG00000001749|UniProtKB=H2Q0Q4	Uncharacterized protein	ISS	8386525	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P05913	Enkephalin release	P05974	G-Protein (i)	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	DICDI|dictyBase=DDB_G0292996|UniProtKB=P03967	Ras-like protein rasD	ISS	85024887	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BOVIN|Gene=ACTG2|UniProtKB=Q5E9B5	Actin, gamma-enteric smooth muscle	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P05731	GABA-B receptor II signaling	P05752	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P05731	GABA-B receptor II signaling	P05760	AC	HUMAN|HGNC=236|UniProtKB=O95622	Adenylate cyclase type 5	ISS	94139935	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00059	p53 pathway	P04633	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P06664	Gonadotropin-releasing hormone receptor pathway	P06772	Tubulin	MOUSE|MGI=MGI=98869|UniProtKB=P68369	Tubulin alpha-1A chain	RCA			PTHR11588:SF133	TUBULIN ALPHA-1A CHAIN
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=107436|UniProtKB=P70408	Cadherin-10	IDA	8120095	PubMed	PTHR24027:SF290	CADHERIN-10
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DAPPU|EnsemblGenome=DAPPUDRAFT_206575|UniProtKB=E9FUX0	Guanine nucleotide binding protein, beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00021	FGF signaling pathway	P00632	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	TAKRU|Ensembl=ENSTRUG00000015959|UniProtKB=H2UV27	Uncharacterized protein	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04552	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00049	Parkinson disease	P01219	SAPK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00780	Microtubule	ORYSJ|EnsemblGenome=OS05G0413200|UniProtKB=Q76FS3	Tubulin beta-6 chain	IDA	12932731	PubMed	PTHR11588:SF249	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00045	Notch signaling pathway	P01099	Notch	CANLF|Ensembl=ENSCAFG00000019633|UniProtKB=F1PDC7	Uncharacterized protein	ISS	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	MACMU|Ensembl=ENSMMUG00000004657|UniProtKB=G7MVY8	Furin	ISS	11861638	PubMed	PTHR42884:SF1	FURIN
P00034	Integrin signalling pathway	P00919	Arf6	DAPPU|EnsemblGenome=DAPPUDRAFT_309391|UniProtKB=E9HCC9	Putative uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	G04699	BAI-1	MOUSE|MGI=MGI=2451244|UniProtKB=Q8CGM1	Adhesion G protein-coupled receptor B2	ISS			PTHR12011:SF41	ADHESION G PROTEIN-COUPLED RECEPTOR B2
P00049	Parkinson disease	P01238	14-3-3	ARATH|TAIR=AT1G78300|UniProtKB=Q01525	14-3-3-like protein GF14 omega	IDA	10407019	PubMed	PTHR18860:SF26	14-3-3 FAMILY PROTEIN-RELATED
P00006	Apoptosis signaling pathway	P00268	GCK	CANLF|Ensembl=ENSCAFG00000014383|UniProtKB=E2RGP4	Mitogen-activated protein kinase kinase kinase kinase	ISS			PTHR24361:SF324	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 5
P00019	Endothelin signaling pathway	P00591	PLCbeta	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05734	Synaptic vesicle trafficking	P05779	Synaptobrevin	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	RCA	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00056	VEGF signaling pathway	P01407	Erk	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00048	PI3 kinase pathway	P01192	p110	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02728	Arginine biosynthesis	P02846	Ornithine carbamoyl transferase	ECOLI|EcoGene=EG10067|UniProtKB=P06960	Ornithine carbamoyltransferase chain F	ISS			PTHR11405:SF42	ORNITHINE CARBAMOYLTRANSFERASE CHAIN F-RELATED
P00053	T cell activation	P01319	PAK	MOUSE|MGI=MGI=1339984|UniProtKB=Q8CIN4	Serine/threonine-protein kinase PAK 2	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00005	Angiogenesis	P00213	FGF	MOUSE|MGI=MGI=95515|UniProtKB=P61148	Fibroblast growth factor 1	ISS	12095987	PubMed	PTHR11486:SF86	FIBROBLAST GROWTH FACTOR 1
P00005	Angiogenesis	P00190	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	8262392	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00052	TGF-beta signaling pathway	P01275	P38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	TAS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04398	p53 pathway feedback loops 2	P04661	PI3K	XENTR|Xenbase=XB-GENE-6085226|UniProtKB=F6ZM84	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00036	Interleukin signaling pathway	P00990	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04395	Vasopressin synthesis	P04594	Neurophysin	PANTR|Ensembl=ENSPTRG00000013189|UniProtKB=H2QJV1	Uncharacterized protein	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00057	Wnt signaling pathway	P01448	CBP	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	RAT|RGD=628837|UniProtKB=P60711	Actin, cytoplasmic 1	IC	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PRIPA|Gene=PPA23459|UniProtKB=H3FMF2	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00023	General transcription regulation	P00669	TFIIEalpha	CANLF|Ensembl=ENSCAFG00000011306|UniProtKB=E2R3P2	Uncharacterized protein	ISS	92065982	PubMed	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00057	Wnt signaling pathway	P01447	Dishevelled	RAT|RGD=620632|UniProtKB=Q9WVB9	Segment polarity protein dishevelled homolog DVL-1	ISS	11212302	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P00036	Interleukin signaling pathway	P00973	PKB	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01199	Galpha	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	BOVIN|Ensembl=ENSBTAG00000019210|UniProtKB=F1MJV4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00023	General transcription regulation	P00666	TFIIE	MACMU|Ensembl=ENSMMUG00000001596|UniProtKB=F7GV34	General transcription factor IIE subunit 1	ISS	189962	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05916	Opioid prodynorphin pathway	P05998	Kappa Receptor	CANLF|Ensembl=ENSCAFG00000032542|UniProtKB=J9P639	Uncharacterized protein	ISS	11259498	PubMed	PTHR24229:SF1	KAPPA-TYPE OPIOID RECEPTOR
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00005	Angiogenesis	P00220	c-Jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000011761|UniProtKB=F1MDE1	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P05913	Enkephalin release	P05977	G-Protein (s)	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00053	T cell activation	P01305	Calmodulin	CANLF|Ensembl=ENSCAFG00000016335|UniProtKB=J9NXY2	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF322	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	PANTR|Ensembl=ENSPTRG00000004718|UniProtKB=H2Q5I0	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00010	B cell activation	P00381	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00785	Cytochrome c	CAEEL|WormBase=WBGene00000869|UniProtKB=Q18853	CYtochrome C	IDA	9027315	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	BOVIN|Ensembl=ENSBTAG00000020887|UniProtKB=F1MP22	Uncharacterized protein	ISS	14507926	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00046	Oxidative stress response	P01135	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00551	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00060	Ubiquitin proteasome pathway	P01491	E2	SCHPO|PomBase=SPCC1259.15c|UniProtKB=O00103	Ubiquitin-conjugating enzyme E2-20 kDa	ISS			PTHR43898:SF9	UBIQUITIN-CONJUGATING ENZYME E2 C
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00006	Apoptosis signaling pathway	P00269	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02766	Phenylethylamine degradation	P03103	Phenylethylamine oxidase	MOUSE|MGI=MGI=1917011|UniProtKB=E9Q745	Amine oxidase	ISS			PTHR10638:SF26	AMINE OXIDASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	DROME|FlyBase=FBgn0010399|UniProtKB=Q24418	Glutamate [NMDA] receptor subunit 1	IC	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P06959	CCKR signaling map	P07228	MAPK1/3	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	RCA	18039929	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00060	Ubiquitin proteasome pathway	P01490	E3	CANLF|Ensembl=ENSCAFG00000014944|UniProtKB=E2RGH5	Uncharacterized protein	ISS			PTHR10953:SF155	UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00034	Integrin signalling pathway	P00916	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	SULSO|EnsemblGenome=SSO0929|UniProtKB=Q97ZH9	Ribonucleotide reductase (Nrd)	ISS			PTHR43371:SF1	SUBFAMILY NOT NAMED
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00796	Kainate receptor	PANTR|Ensembl=ENSPTRG00000013825|UniProtKB=H2RAK4	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00047	PDGF signaling pathway	P01142	p90RSK	CHICK|Ensembl=ENSGALG00000011473|UniProtKB=F1P1H2	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00045	Notch signaling pathway	P01116	Delta	PANTR|Ensembl=ENSPTRG00000010975|UniProtKB=H2QGB2	Uncharacterized protein	ISS	10742114	PubMed	PTHR24044:SF308	DELTA-LIKE PROTEIN 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	12805548	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00017	DNA replication	P00533	Pol delta	MOUSE|MGI=MGI=97741|UniProtKB=P52431	DNA polymerase delta catalytic subunit	ISS	3122029	gi	PTHR10322:SF23	DNA POLYMERASE DELTA CATALYTIC SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05918	p38 MAPK pathway	P06033	TAB2	MOUSE|MGI=MGI=1915902|UniProtKB=Q99K90	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2	ISS			PTHR10351:SF27	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 2
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	GLOVI|Gene=BAC91789|UniProtKB=Q7NEN1	Aldehyde dehydrogenase	IC			PTHR43521:SF2	DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 12A1, MITOCHONDRIAL
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05961	DOPA decarb.	DROME|FlyBase=FBgn0000422|UniProtKB=P05031	Aromatic-L-amino-acid decarboxylase	ISS	90339966	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P02723	Adenine and hypoxanthine salvage pathway	P02805	Adenine phosphorylase	STRCO|Gene=CAD30908|UniProtKB=Q9EWV2	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02783	Tryptophan biosynthesis	P03211	Phosphribosyl anthranilate isomerase	ARATH|TAIR=AT5G05590|UniProtKB=Q42527	N-(5'-phosphoribosyl)anthranilate isomerase 2, chloroplastic	ISS			PTHR42894:SF1	N- 5'-PHOSPHORIBOSYL ANTHRANILATE ISOMERASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00748	Gbeta5L	XENTR|Xenbase=XB-GENE-977853|UniProtKB=F7EBE7	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00047	PDGF signaling pathway	P01151	PKB	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	MOUSE|MGI=MGI=1298218|UniProtKB=O88572	Low-density lipoprotein receptor-related protein 6	IDA	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00036	Interleukin signaling pathway	P00973	PKB	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	RAT|RGD=3425|UniProtKB=P97887	Presenilin-1	TAS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00019	Endothelin signaling pathway	P00589	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00011	Blood coagulation	P00442	FXII	BOVIN|Gene=F12|UniProtKB=P98140	Coagulation factor XII	ISS	1352406	gi	PTHR44246:SF3	COAGULATION FACTOR XII
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MACMU|Ensembl=ENSMMUG00000005238|UniProtKB=F7BWT2	Uncharacterized protein	ISS	1608964	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00018	EGF receptor signaling pathway	P00551	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	CANLF|Ensembl=ENSCAFG00000004930|UniProtKB=E2RFB5	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00019	Endothelin signaling pathway	P00577	PI3K	CAEEL|WormBase=WBGene00006932|UniProtKB=Q9TXI7	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	11927551	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04393	Ras Pathway	P04556	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05918	p38 MAPK pathway	P06019	ATF1	MONDO|Ensembl=ENSMODG00000006303|UniProtKB=F7BRQ2	Uncharacterized protein	ISS	11390664	PubMed	PTHR22952:SF258	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-1
P00057	Wnt signaling pathway	P01443	Phospholipase C	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04393	Ras Pathway	P04542	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01411	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00049	Parkinson disease	P01232	CASK	DROME|FlyBase=FBgn0013759|UniProtKB=Q24210	Peripheral plasma membrane protein CASK	IPI	11679592	PubMed	PTHR23122:SF7	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00646	RasGAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	IPI	88318957	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00060	Ubiquitin proteasome pathway	P01490	E3	BOVIN|Ensembl=ENSBTAG00000008025|UniProtKB=F1N703	Uncharacterized protein	ISS			PTHR11254:SF357	UBIQUITIN-PROTEIN LIGASE E3C
P00048	PI3 kinase pathway	P01188	Gbetagamma	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	10477300	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P04393	Ras Pathway	P04575	TAK	RAT|RGD=1359474|UniProtKB=A0A0G2K9U9	Protein Map3k7cl	ISS			PTHR26392:SF77	EXTRACELLULAR TYROSINE-PROTEIN KINASE PKDCC
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00057	Wnt signaling pathway	P01451	Galpha	HUMAN|HGNC=4383|UniProtKB=P30679	Guanine nucleotide-binding protein subunit alpha-15	IDA	8838318	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P00038	JAK/STAT signaling pathway	P01031	PIAS	HUMAN|HGNC=17311|UniProtKB=O75928	E3 SUMO-protein ligase PIAS2	ISS	8682149	PubMed	PTHR10782:SF12	E3 SUMO-PROTEIN LIGASE PIAS2
P00029	Huntington disease	P00780	Microtubule	CAEEL|WormBase=WBGene00006537|UniProtKB=P52275	Tubulin beta-2 chain	IDA	12932731	PubMed	PTHR11588:SF84	TUBULIN BETA-2 CHAIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	IC	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01447	Dishevelled	MOUSE|MGI=MGI=106613|UniProtKB=Q60838	Segment polarity protein dishevelled homolog DVL-2	ISS	11212302	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P00029	Huntington disease	P00807	Actin	DICPU|Gene=DICPUDRAFT_48914|UniProtKB=F0ZK40	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF154	ACTIN-17-RELATED
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	CANLF|Ensembl=ENSCAFG00000001103|UniProtKB=F1PVZ8	Uncharacterized protein	ISS	11055438	PubMed	PTHR10117:SF9	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 7
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000010521|UniProtKB=F7DQK7	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	DANRE|ZFIN=ZDB-GENE-040108-1|UniProtKB=F1QKS3	Uncharacterized protein	ISS			PTHR18945:SF535	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MOUSE|MGI=MGI=88176|UniProtKB=P98063	Bone morphogenetic protein 1	TAS	9759503	PubMed	PTHR43978:SF3	BONE MORPHOGENETIC PROTEIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00036	Interleukin signaling pathway	P00989	Ets	MACMU|Ensembl=ENSMMUG00000020873|UniProtKB=F7HN68	Uncharacterized protein	ISS	8970723	PubMed	PTHR11849:SF17	TRANSCRIPTION FACTOR SPI-C
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	DANRE|ZFIN=ZDB-GENE-020125-5|UniProtKB=A2CG69	Uncharacterized protein	ISS	20112749	PubMed	PTHR18966:SF356	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00219	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IDA	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00633	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00977	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00059	p53 pathway	P04609	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00034	Integrin signalling pathway	P00920	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	CHICK|Ensembl=ENSGALG00000015336|UniProtKB=Q03481	Alpha8 subunit of nicotinic acetylcholine receptor	ISS	11404397	PubMed	PTHR18945:SF761	ALPHA8 SUBUNIT OF NICOTINIC ACETYLCHOLINE RECEPTOR
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00053	T cell activation	P01315	Calcineurin	CANLF|Ensembl=ENSCAFG00000014818|UniProtKB=E2RJ59	Serine/threonine-protein phosphatase	ISS	12091710	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00828	Galphai	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	RCA			PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000004741|UniProtKB=H2Q5K0	Uncharacterized protein	ISS			PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00012	Cadherin signaling pathway	P00474	Wnt	MONDO|Ensembl=ENSMODG00000001196|UniProtKB=F7GH85	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00047	PDGF signaling pathway	P01159	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	EMENI|EnsemblGenome=CADANIAG00004263|UniProtKB=Q8TFN0	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04558	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	IDA	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00034	Integrin signalling pathway	P00951	Jnk	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00193	SOS-1	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05730	Endogenous cannabinoid signaling	P05743	CB1	ORNAN|Ensembl=ENSOANG00000000534|UniProtKB=F7CUB0	Uncharacterized protein	ISS	2165569	PubMed	PTHR22750:SF47	CANNABINOID RECEPTOR 1
P00059	p53 pathway	G01579	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00048	PI3 kinase pathway	P01192	p110	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00017	DNA replication	P00531	Pol alpha	HUMAN|HGNC=9173|UniProtKB=P09884	DNA polymerase alpha catalytic subunit	ISS	14499601	PubMed	PTHR10322:SF21	DNA POLYMERASE ALPHA CATALYTIC SUBUNIT
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00047	PDGF signaling pathway	P01159	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00021	FGF signaling pathway	P00629	PP2A	HUMAN|HGNC=9299|UniProtKB=P67775	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04393	Ras Pathway	P04553	PAK	MOUSE|MGI=MGI=1339975|UniProtKB=O88643	Serine/threonine-protein kinase PAK 1	IDA	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MONDO|Ensembl=ENSMODG00000018065|UniProtKB=F7G485	Uncharacterized protein	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00025	Hedgehog signaling pathway	P00682	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00624	14-3-3	PANTR|Ensembl=ENSPTRG00000013529|UniProtKB=H2R8X6	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00034	Integrin signalling pathway	P00924	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00467	alpha-catenin	DANRE|ZFIN=ZDB-GENE-991207-24|UniProtKB=Q9PVF8	Catenin (Cadherin-associated protein), alpha	IDA	10456847	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	1718748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00778	NMDA receptor	RAT|RGD=2738|UniProtKB=Q00960	Glutamate receptor ionotropic, NMDA 2B	IDA	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00036	Interleukin signaling pathway	P00997	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MACMU|Ensembl=ENSMMUG00000005676|UniProtKB=F6VQA9	Uncharacterized protein	ISS	5478218	gi	PTHR10489:SF611	C-C CHEMOKINE RECEPTOR TYPE 6
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000008719|UniProtKB=F1MZX0	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05730	Endogenous cannabinoid signaling	P05746	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00005	Angiogenesis	P00211	GSK3beta	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IDA	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00021	FGF signaling pathway	P00633	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01076	CAT	CAEBR|Gene=CBG08305|UniProtKB=A8X694	Protein CBR-CHA-1	ISS	97225904	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P05730	Endogenous cannabinoid signaling	P05751	Galpha	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00056	VEGF signaling pathway	P01411	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P00029	Huntington disease	P00780	Microtubule	TAKRU|Ensembl=ENSTRUG00000000002|UniProtKB=H2RIN9	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF236	SUBFAMILY NOT NAMED
P00053	T cell activation	P01322	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00034	Integrin signalling pathway	P00925	MEK	CHICK|Ensembl=ENSGALG00000004735|UniProtKB=F1NHE1	Uncharacterized protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04393	Ras Pathway	P04572	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	MACMU|Ensembl=ENSMMUG00000021927|UniProtKB=F6T4B4	Uncharacterized protein	ISS	3487386	PubMed	PTHR23220:SF69	INTEGRIN ALPHA-9
P00005	Angiogenesis	P00203	Erk	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05918	p38 MAPK pathway	P06020	p38delta	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	RCA	12810719	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01415	MAPKAPK2/3	PANTR|Ensembl=ENSPTRG00000001915|UniProtKB=H2Q104	Mitogen-activated protein kinase-activated protein kinase 2	ISS	8262198	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00624	14-3-3	CRYNJ|EnsemblGenome=CNL03930|UniProtKB=Q5K8Z6	14-3-3 protein, putative	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	TAS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05913	Enkephalin release	P05973	GPCR (i)	RAT|RGD=3233|UniProtKB=P33533	Delta-type opioid receptor	ISS	12093103	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00021	FGF signaling pathway	P00628	JNK1-3	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	ANOGA|EnsemblGenome=AGAP011840|UniProtKB=Q7PZC6	AGAP011840-PA (Fragment)	ISS	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00029	Huntington disease	P00805	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	MONDO|Ensembl=ENSMODG00000005494|UniProtKB=F7BXN9	Uncharacterized protein	ISS			PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P05731	GABA-B receptor II signaling	P05752	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	RCA	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05913	Enkephalin release	P05974	G-Protein (i)	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01446	Calcineurin	RAT|RGD=3383|UniProtKB=P20651	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	IDA	7532676	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00920	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00049	Parkinson disease	P01242	Casein kinase I	DANRE|ZFIN=ZDB-GENE-020419-19|UniProtKB=Q8JHE0	Casein kinase 1-alphaLS	IDA	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P06664	Gonadotropin-releasing hormone receptor pathway	P06860	Rac1	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	RCA	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00045	Notch signaling pathway	P01101	Su(H)	XENTR|Xenbase=XB-GENE-490756|UniProtKB=F7BXC9	Uncharacterized protein (Fragment)	ISS	12145413	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00012	Cadherin signaling pathway	P00470	F-actin	RAT|RGD=2026|UniProtKB=P68035	Actin, alpha cardiac muscle 1	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00056	VEGF signaling pathway	P01417	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CANLF|Ensembl=ENSCAFG00000017522|UniProtKB=Q076A4	Myosin-8	ISS	10938134	PubMed	PTHR13140:SF368	MYOSIN-8
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	MOUSE|MGI=MGI=1351339|UniProtKB=Q14BI2	Metabotropic glutamate receptor 2	ISS	20012997	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00057	Wnt signaling pathway	P01457	GBeta	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IDA	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00018	EGF receptor signaling pathway	P00551	Akt	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	IGI	12719720	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00005	Angiogenesis	P00211	GSK3beta	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00029	Huntington disease	P00807	Actin	DANRE|ZFIN=ZDB-GENE-030131-172|UniProtKB=Q6IQR3	Actin, alpha, cardiac muscle 1a	IDA	11889126	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00048	PI3 kinase pathway	P01205	NOS	PANTR|Ensembl=ENSPTRG00000019868|UniProtKB=H2QVM2	Nitric oxide synthase	ISS	22462730	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00034	Integrin signalling pathway	P00923	Arf1	TRIAD|EnsemblGenome=TriadG63238|UniProtKB=B3RQZ1	ADP-ribosylation factor 1	ISS	11752622	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	RAT|RGD=1310952|UniProtKB=A0A0G2JZI2	Protein Eprs	ISS			PTHR43382:SF2	BIFUNCTIONAL GLUTAMATE/PROLINE--TRNA LIGASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2743|UniProtKB=P31421	Metabotropic glutamate receptor 2	IDA	12488551	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00049	Parkinson disease	P01219	SAPK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	14744428	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04393	Ras Pathway	P04550	Ral	ANOGA|EnsemblGenome=AGAP012108|UniProtKB=Q7PKD8	AGAP012108-PA (Fragment)	ISS			PTHR24070:SF258	RAS-RELATED PROTEIN RAL-A
P04393	Ras Pathway	P04541	p90RSK	MACMU|Ensembl=ENSMMUG00000022111|UniProtKB=F7H7W3	Ribosomal protein S6 kinase	ISS	12769834	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CHICK|Ensembl=ENSGALG00000008339|UniProtKB=E1BQS9	Uncharacterized protein	ISS			PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05734	Synaptic vesicle trafficking	P05778	SNAP-25	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	TAS	12805548	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MOUSE|MGI=MGI=107405|UniProtKB=Q64280	Left-right determination factor 1	TAS	9759503	PubMed	PTHR11848:SF181	LEFT-RIGHT DETERMINATION FACTOR 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02738	De novo purine biosynthesis	P02907	dADP kinase	MYCTU|EnsemblGenome=Rv2445c|UniProtKB=P9WJH7	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	BOVIN|Ensembl=ENSBTAG00000018445|UniProtKB=E1BK87	Uncharacterized protein	ISS	11554554	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DROME|FlyBase=FBgn0000043|UniProtKB=P02572	Actin-42A	ISS	14684598	PubMed	PTHR11937:SF369	ACTIN-42A
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	CANLF|Ensembl=ENSCAFG00000004956|UniProtKB=E2REH3	Uncharacterized protein	ISS	14580336	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00048	PI3 kinase pathway	P01185	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Gene=PCDHB13|UniProtKB=Q5DRD6	Protocadherin beta-13	ISS	8120095	PubMed	PTHR24028:SF61	PROTOCADHERIN BETA-13
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CAEEL|WormBase=WBGene00004037|UniProtKB=Q9XWB7	Phosphoinositide phospholipase C	ISS			PTHR10336:SF9	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05731	GABA-B receptor II signaling	P05754	Ggamma	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	RAT|RGD=621407|UniProtKB=Q62762	Casein kinase I isoform gamma-2	IDA	11437445	PubMed	PTHR11909:SF157	CASEIN KINASE I ISOFORM GAMMA-2
P00023	General transcription regulation	P00660	RNA Polymerase II	CANLF|Ensembl=ENSCAFG00000008720|UniProtKB=E2RQ42	Uncharacterized protein	ISS	2187864	PubMed	PTHR11800:SF2	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	RCA	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_114535|UniProtKB=C3ZHN2	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DROME|FlyBase=FBgn0001105|UniProtKB=P26308	Guanine nucleotide-binding protein subunit beta-1	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00005	Angiogenesis	P00249	PAK	PANTR|Ensembl=ENSPTRG00000022187|UniProtKB=Q7YQL4	Serine/threonine-protein kinase PAK 3	ISS	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00004	Alzheimer disease-presenilin pathway	P00167	CD44 transmembrane fragment	MACMU|Ensembl=ENSMMUG00000004327|UniProtKB=F6ZDZ8	Uncharacterized protein	ISS	12223485	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MOUSE|MGI=MGI=88398|UniProtKB=Q9ERZ3	Muscarinic acetylcholine receptor M3	IDA	11166329	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MOUSE|MGI=MGI=88181|UniProtKB=P49003	Bone morphogenetic protein 5	TAS	9759503	PubMed	PTHR11848:SF139	BONE MORPHOGENETIC PROTEIN 5
P00048	PI3 kinase pathway	P01181	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04393	Ras Pathway	P04570	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01438	PP2A	IXOSC|EnsemblGenome=ISCW014549|UniProtKB=B7QGY5	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MOUSE|MGI=MGI=95821|UniProtKB=Q01097	Glutamate receptor ionotropic, NMDA 2B	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	10891487	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00057	Wnt signaling pathway	P01451	Galpha	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	IDA	1333286	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	PANTR|Ensembl=ENSPTRG00000014846|UniProtKB=H2R0Z4	Uncharacterized protein	ISS	11830666	PubMed	PTHR10489:SF649	C-C CHEMOKINE RECEPTOR TYPE 3
P00053	T cell activation	P01309	fos	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	TAS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00632	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01152	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	20908895	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00906	Rap1	RAT|RGD=1359694|UniProtKB=P62836	Ras-related protein Rap-1A	ISS	8576107	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00057	Wnt signaling pathway	P01458	Protein Kinase C	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00240	FRS-2	MOUSE|MGI=MGI=1100860|UniProtKB=Q8C180	Fibroblast growth factor receptor substrate 2	ISS	10464310	PubMed	PTHR21258:SF40	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	PANTR|Ensembl=ENSPTRG00000010617|UniProtKB=H2QFL8	Notch 3	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00012	Cadherin signaling pathway	P00470	F-actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	IC	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04393	Ras Pathway	P04558	p38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	HUMAN|HGNC=1389|UniProtKB=Q00975	Voltage-dependent N-type calcium channel subunit alpha-1B	IDA	8386525	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00029	Huntington disease	P00790	beta-Tubulin	SCHMA|EnsemblGenome=Smp_192110|UniProtKB=G4VHK8	Putative tubulin beta chain	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01160	IP3 receptor	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000002125|UniProtKB=F1N461	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00005	Angiogenesis	P00243	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MACMU|Gene=CXCR2|UniProtKB=Q28519	C-X-C chemokine receptor type 2 (Fragment)	ISS	4504683	gi	PTHR10489:SF689	C-X-C CHEMOKINE RECEPTOR TYPE 2
P00010	B cell activation	P00383	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IDA	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00627	ERK1-2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00059	p53 pathway	G01579	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00057	Wnt signaling pathway	P01438	PP2A	XENTR|Xenbase=XB-GENE-484003|UniProtKB=Q6P365	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00015	Circadian clock system	G01501	cry	MOUSE|MGI=MGI=1270841|UniProtKB=P97784	Cryptochrome-1	IEP	10217146	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MACMU|Ensembl=ENSMMUG00000002439|UniProtKB=F6PJN8	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04393	Ras Pathway	P04559	Rac	ORYSJ|EnsemblGenome=OS02G0834000|UniProtKB=Q6EP31	Rac-like GTP-binding protein 5	ISS	12932731	PubMed	PTHR24072:SF194	RAC-LIKE GTP-BINDING PROTEIN ARAC4-RELATED
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00037	Ionotropic glutamate receptor pathway	P01018	Glu1	CHICK|Ensembl=ENSGALG00000004083|UniProtKB=Q90855	AMPA receptor GluR1/A	ISS	12941441	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00018	EGF receptor signaling pathway	P00557	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04398	p53 pathway feedback loops 2	P04664	cyclin E	MOUSE|MGI=MGI=88316|UniProtKB=Q61457	G1/S-specific cyclin-E1	ISS	6671698	gi	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	RAT|RGD=70958|UniProtKB=P19492	Glutamate receptor 3	IC	12871085	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00053	T cell activation	P01306	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00021	FGF signaling pathway	P00631	Grb2	CAEEL|WormBase=WBGene00004774|UniProtKB=P29355	Sex muscle abnormal protein 5	IPI	8307166	PubMed	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00021	FGF signaling pathway	P00632	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00927	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IDA	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00011	Blood coagulation	P00429	PN2	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IPI	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MOUSE|MGI=MGI=96274|UniProtKB=P28334	5-hydroxytryptamine receptor 1B	IDA			PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P00038	JAK/STAT signaling pathway	P01027	STAT	HUMAN|HGNC=11364|UniProtKB=P40763	Signal transducer and activator of transcription 3	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	IDA	14984365	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	HUMAN|HGNC=11641|UniProtKB=Q9NQB0	Transcription factor 7-like 2	IEP	11266476	PubMed	PTHR10373:SF32	TRANSCRIPTION FACTOR 7-LIKE 2
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MOUSE|MGI=MGI=104515|UniProtKB=P34821	Bone morphogenetic protein 8A	TAS	9759503	PubMed	PTHR11848:SF119	BONE MORPHOGENETIC PROTEIN 8A
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P06959	CCKR signaling map	P07142	YES1	HUMAN|HGNC=12841|UniProtKB=P07947	Tyrosine-protein kinase Yes	RCA	14634819	PubMed	PTHR24418:SF90	TYROSINE-PROTEIN KINASE YES
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	HUMAN|HGNC=130|UniProtKB=P62736	Actin, aortic smooth muscle	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00029	Huntington disease	P00762	HAP1	HUMAN|HGNC=4812|UniProtKB=P54257	Huntingtin-associated protein 1	IPI	7477378	PubMed	PTHR15751:SF14	HUNTINGTIN-ASSOCIATED PROTEIN 1
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00370	NFkappaB	HUMAN|HGNC=7795|UniProtKB=Q00653	Nuclear factor NF-kappa-B p100 subunit	IDA	9133421	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00019	Endothelin signaling pathway	P00570	PKA	SCHPO|PomBase=SPAC8C9.03|UniProtKB=P36600	cAMP-dependent protein kinase regulatory subunit	ISS	176892	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00925	MEK	MONDO|Ensembl=ENSMODG00000001404|UniProtKB=F7BD74	Uncharacterized protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00010	B cell activation	P00402	Jnk	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00048	PI3 kinase pathway	P01185	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00020	FAS signaling pathway	P00615	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00059	p53 pathway	P04633	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00973	PKB	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	IDA	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04393	Ras Pathway	P04547	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00021	FGF signaling pathway	P00627	ERK1-2	ARATH|TAIR=AT3G59790|UniProtKB=Q9M1Z5	Mitogen-activated protein kinase 10	ISS			PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00010	B cell activation	P00384	p38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IDA	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P05918	p38 MAPK pathway	P06023	MEF	XENTR|Xenbase=XB-GENE-486958|UniProtKB=F6WS85	Uncharacterized protein	ISS	11274345	PubMed	PTHR11945:SF145	MYOCYTE-SPECIFIC ENHANCER FACTOR 2A
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01275	P38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00029	Huntington disease	P00790	beta-Tubulin	CANLF|Ensembl=ENSCAFG00000018832|UniProtKB=E2QYC2	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00019	Endothelin signaling pathway	P00566	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00624	14-3-3	ARATH|TAIR=AT2G42590|UniProtKB=Q96299	14-3-3-like protein GF14 mu	ISS	10407019	PubMed	PTHR18860:SF31	14-3-3-LIKE PROTEIN GF14 MU
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	RCA	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01417	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00470	F-actin	SCHMA|EnsemblGenome=Smp_202970|UniProtKB=G4VLN1	Putative uncharacterized protein Smp_202970	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	TAKRU|Ensembl=ENSTRUG00000002793|UniProtKB=H2S271	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF676	MYOSIN, HEAVY POLYPEPTIDE 2, FAST MUSCLE SPECIFIC
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	DICPU|Gene=DICPUDRAFT_91511|UniProtKB=F0ZDJ1	Serine/threonine-protein phosphatase	ISS	10452519	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00552	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00021	FGF signaling pathway	P00629	PP2A	PHYPA|Gene=PHYPADRAFT_193894|UniProtKB=A9TD31	Serine/threonine-protein phosphatase	ISS			PTHR11668:SF24	SERINE/THREONINE-PROTEIN PHOSPHATASE 6 CATALYTIC SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IDA	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P02772	Pyruvate metabolism	P03140	Pyruvate Carboxylase	CANLF|Ensembl=ENSCAFG00000012081|UniProtKB=F1P6G9	Pyruvate carboxylase	ISS	12112657	PubMed	PTHR43778:SF2	PYRUVATE CARBOXYLASE, MITOCHONDRIAL
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Ensembl=ENSBTAG00000013047|UniProtKB=E1BLE8	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	TAS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00266	SEK1	HUMAN|HGNC=6844|UniProtKB=P45985	Dual specificity mitogen-activated protein kinase kinase 4	RCA			PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00023	General transcription regulation	P00658	TBP-associated factors	CANLF|Ensembl=ENSCAFG00000001622|UniProtKB=E2RN76	Uncharacterized protein	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00010	B cell activation	P00381	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	ANOGA|EnsemblGenome=AGAP006475|UniProtKB=Q5TQX0	AGAP006475-PA	IDA	9065779	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00059	p53 pathway	P04635	Sumo-1 ligase	CHICK|Ensembl=ENSGALG00000020973|UniProtKB=Q5ZHQ1	Small ubiquitin-related modifier 3	ISS			PTHR10562:SF50	SMALL UBIQUITIN-RELATED MODIFIER 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	RCA	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00182	p38MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00029	Huntington disease	P00805	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IDA	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02738	De novo purine biosynthesis	P02909	GDP reductase	METAC|EnsemblGenome=MA_1665|UniProtKB=Q8TQ86	Ribonucleotide reductase	ISS			PTHR43371:SF1	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01448	CBP	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P02761	Pantothenate biosynthesis	P03067	3-methyl-2-oxobutanoate hydroxymethyltransferase	RHOBA|EnsemblGenome=RB9090|UniProtKB=Q7UM39	3-methyl-2-oxobutanoate hydroxymethyltransferase	ISS			PTHR20881:SF0	3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE
P05731	GABA-B receptor II signaling	P05753	Ca channel	MOUSE|MGI=MGI=1201678|UniProtKB=Q5SUF7	Protein Cacna1g	ISS	14526084	PubMed	PTHR10037:SF137	VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1G
P00049	Parkinson disease	P01208	Hsp70	LEIMA|EnsemblGenome=LmjF.26.1240|UniProtKB=Q4Q970	Heat shock protein 70-related protein	IDA	12150907	PubMed	PTHR19375:SF254	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00965	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IC	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MACMU|Ensembl=ENSMMUG00000004904|UniProtKB=F7CJE4	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00057	Wnt signaling pathway	P01444	Wnt	PANTR|Ensembl=ENSPTRG00000019627|UniProtKB=H2QVA4	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00059	p53 pathway	P04616	PDK1/2	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	TAS	15210700	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	MOUSE|MGI=MGI=99578|UniProtKB=Q61616	D(1A) dopamine receptor	ISS	9700720	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00005	Angiogenesis	P00253	Axin	PANTR|Ensembl=ENSPTRG00000007537|UniProtKB=H2R1H5	Uncharacterized protein	ISS	12549854	PubMed	PTHR10845:SF11	AXIN-1
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00193	SOS-1	DICDI|dictyBase=DDB_G0276019|UniProtKB=Q552M5	Ras guanine nucleotide exchange factor Y	ISS			PTHR23113:SF99	PROTEIN SON OF SEVENLESS
P02765	Phenylalanine biosynthesis	P03099	Prephenate dehydratase	RHOBA|EnsemblGenome=RB9107|UniProtKB=Q7UM30	P-protein (PheA)	ISS			PTHR21022:SF0	PREPHENATE DEHYDRATASE-RELATED
P00005	Angiogenesis	P00189	Fzd	CANLF|Ensembl=ENSCAFG00000013547|UniProtKB=E2QVP7	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF126	FRIZZLED-5
P00057	Wnt signaling pathway	P01472	Histone deacetylase	CAEEL|WormBase=WBGene00001836|UniProtKB=G5ECH0	Histone deacetylase	IDA	10485845	PubMed	PTHR10625:SF140	HISTONE DEACETYLASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00020	FAS signaling pathway	P00600	PARP	NEUCR|EnsemblGenome=EFNCRG00000008815|UniProtKB=Q7S7M3	Poly [ADP-ribose] polymerase	TAS	12101391	PubMed	PTHR10459:SF60	POLY  ADP-RIBOSE  POLYMERASE 2
P00059	p53 pathway	P04635	Sumo-1 ligase	MACMU|Ensembl=ENSMMUG00000002024|UniProtKB=F6TMI7	Small ubiquitin-related modifier	ISS			PTHR10562:SF50	SMALL UBIQUITIN-RELATED MODIFIER 3
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1203729|UniProtKB=Q61194	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P04395	Vasopressin synthesis	P04597	Signal Peptide	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04558	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IDA	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	XENTR|Xenbase=XB-GENE-481916|UniProtKB=F6YF14	Presenilin	ISS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00011	Blood coagulation	P00433	uPAR	CHICK|Gene=PLAU|UniProtKB=P15120	Urokinase-type plasminogen activator	IC			PTHR44246:SF2	UROKINASE-TYPE PLASMINOGEN ACTIVATOR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2344|UniProtKB=P08485	Muscarinic acetylcholine receptor M4	IDA	8100450	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00010	B cell activation	P00381	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00010	B cell activation	P00384	p38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IDA	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04393	Ras Pathway	P04567	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00029	Huntington disease	P00775	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MOUSE|MGI=MGI=87891|UniProtKB=Q9ERK7	Neuronal acetylcholine receptor subunit beta-2	IC	15155845	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P00049	Parkinson disease	P01219	SAPK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	NAS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	RAT|RGD=621522|UniProtKB=Q64649	Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform	IDA	10487978	PubMed	PTHR10749:SF4	PHOSPHORYLASE B KINASE REGULATORY SUBUNIT ALPHA, SKELETAL MUSCLE ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	TAS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02742	Tetrahydrofolate biosynthesis	P02951	GTP cyclohydrolase	SCHPO|PomBase=SPAC17A5.13|UniProtKB=O13774	GTP cyclohydrolase 1	ISS			PTHR11109:SF0	GTP CYCLOHYDROLASE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	MONDO|Ensembl=ENSMODG00000002696|UniProtKB=F7CY56	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF335	CALMODULIN, STRIATED MUSCLE
P04397	p53 pathway by glucose deprivation	P04641	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00824	PTEN	TAKRU|Ensembl=ENSTRUG00000009851|UniProtKB=H2TJ90	Uncharacterized protein	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00010	B cell activation	P00367	NFAT	BOVIN|Ensembl=ENSBTAG00000004368|UniProtKB=F1MSU2	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	DROME|FlyBase=FBgn0019947|UniProtKB=O02194	Presenilin homolog	IDA	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00238	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	RAT|RGD=620023|UniProtKB=P10980	Muscarinic acetylcholine receptor M2	ISS	11166329	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05760	AC	XENTR|Xenbase=XB-GENE-999257|UniProtKB=F7CEX4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF319	ADENYLATE CYCLASE TYPE 9
P02738	De novo purine biosynthesis	P02889	dGDP kinase	PANTR|Ensembl=ENSPTRG00000007605|UniProtKB=H2QAA6	Nucleoside diphosphate kinase	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P00056	VEGF signaling pathway	P01409	cPLA2	PANTR|Ensembl=ENSPTRG00000001787|UniProtKB=H2Q0T0	Phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00006	Apoptosis signaling pathway	P00273	p53	DANRE|ZFIN=ZDB-GENE-990415-270|UniProtKB=P79734	Cellular tumor antigen p53	ISS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	STRPU|EnsemblGenome=SPU_002234|UniProtKB=W4XFS1	Uncharacterized protein	ISS			PTHR23073:SF31	26S PROTEASE REGULATORY SUBUNIT 10B
P00023	General transcription regulation	P00660	RNA Polymerase II	HUMAN|HGNC=9195|UniProtKB=P52434	DNA-directed RNA polymerases I, II, and III subunit RPABC3	ISS	606023	OMIM	PTHR10917:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	PANTR|Ensembl=ENSPTRG00000011042|UniProtKB=H2QGF5	Uncharacterized protein	ISS	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CAEBR|Gene=CBG02162|UniProtKB=A8WS33	Protein CBG02162	ISS	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	TAS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05913	Enkephalin release	P05974	G-Protein (i)	BOVIN|Ensembl=ENSBTAG00000003762|UniProtKB=A5PJS1	GNB5 protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	IC	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IDA	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IC	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05731	GABA-B receptor II signaling	P05758	K channel	ORNAN|Ensembl=ENSOANG00000006119|UniProtKB=F6WTY3	Uncharacterized protein	ISS	2433589	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MOUSE|MGI=MGI=1921305|UniProtKB=Q8K4S1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	12860966	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P04392	P53 pathway feedback loops 1	P04537	p73DeltaN	CANLF|Ensembl=ENSCAFG00000013961|UniProtKB=F1PL57	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00048	PI3 kinase pathway	P01199	Galpha	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00059	p53 pathway	G04694	p110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PANTR|Ensembl=ENSPTRG00000006890|UniProtKB=H2Q943	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	RAT|RGD=67366|UniProtKB=P50393	Cytosolic phospholipase A2	IEA	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00010	B cell activation	P00398	IP3R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	IGI	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	TAS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05917	Opioid proopiomelanocortin pathway	P06009	K+ channel	HUMAN|HGNC=6283|UniProtKB=Q9NPC2	Potassium channel subfamily K member 9	ISS	15282272	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	TAS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02728	Arginine biosynthesis	P02842	N-acetylornithine aminotransferase	ARATH|TAIR=AT1G80600|UniProtKB=Q9M8M7	Acetylornithine aminotransferase, chloroplastic/mitochondrial	ISS	10074354	PubMed	PTHR11986:SF79	ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02738	De novo purine biosynthesis	P02907	dADP kinase	RAT|RGD=1304887|UniProtKB=D3ZPL7	Down syndrome cell adhesion molecule-like 1 (Predicted)	ISS			PTHR44107:SF3	DOWN SYNDROME CELL ADHESION MOLECULE-LIKE PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=3023|UniProtKB=P14416	D(2) dopamine receptor	IDA	1319557	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IDA	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05918	p38 MAPK pathway	P06025	SRF	BOVIN|Ensembl=ENSBTAG00000012777|UniProtKB=E1BJP4	Uncharacterized protein	ISS	15170389	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P05916	Opioid prodynorphin pathway	P06002	G-protein	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00269	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02746	Heme biosynthesis	P02970	Coproporphyrinogen oxidase (oxygen independent)	STRCO|Gene=CAB66237|UniProtKB=Q9RDD2	Putative oxygen-independent coproporphyrinogen III oxidase	ISS			PTHR13932:SF5	OXYGEN-INDEPENDENT COPROPORPHYRINOGEN-III OXIDASE-LIKE PROTEIN YGGW
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MACMU|Ensembl=ENSMMUG00000004886|UniProtKB=F7AGT9	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	DANRE|ZFIN=ZDB-GENE-020419-19|UniProtKB=Q8JHE0	Casein kinase 1-alphaLS	ISS	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00047	PDGF signaling pathway	P01168	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04666	cyclin A	CANLF|Ensembl=ENSCAFG00000004133|UniProtKB=E2RQA2	Uncharacterized protein	ISS			PTHR10177:SF69	CYCLIN-A2
P00057	Wnt signaling pathway	P01438	PP2A	RAT|RGD=1305657|UniProtKB=A0A0G2JTA1	Protein Ppp2r5e	ISS	8703017	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00029	Huntington disease	P00807	Actin	ORYSJ|EnsemblGenome=OS03G0718100|UniProtKB=Q10DV7	Actin-1	IDA	10974003	PubMed	PTHR11937:SF364	ACTIN-11
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04395	Vasopressin synthesis	P04589	Signal Peptidase	SCHPO|PomBase=SPBC1685.03|UniProtKB=O74323	Signal peptidase complex catalytic subunit sec11	IC	2092035	PubMed	PTHR10806:SF6	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11
P05916	Opioid prodynorphin pathway	P05999	provasopressin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00046	Oxidative stress response	P01137	MNK1/2	HUMAN|HGNC=7110|UniProtKB=Q9BUB5	MAP kinase-interacting serine/threonine-protein kinase 1	RCA	11575158	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00057	Wnt signaling pathway	P01465	Ggamma	BOVIN|Ensembl=ENSBTAG00000035697|UniProtKB=Q28024	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IDA	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT4G01370|UniProtKB=Q39024	Mitogen-activated protein kinase 4	IDA	11707292	PubMed	PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	94280860	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00059	p53 pathway	P04609	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	12707323	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MACMU|Ensembl=ENSMMUG00000006253|UniProtKB=F7H582	Uncharacterized protein	ISS	92409599	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00005	Angiogenesis	P00238	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00021	FGF signaling pathway	P00644	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IGI	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04393	Ras Pathway	P04569	Cdc42	TAKRU|Ensembl=ENSTRUG00000013411|UniProtKB=H2UB84	Uncharacterized protein	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	TAKRU|Ensembl=ENSTRUG00000000584|UniProtKB=H2RMN2	Uncharacterized protein	IDA	2039532	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00057	Wnt signaling pathway	P01435	SWI/SNF	HUMAN|HGNC=4861|UniProtKB=Q9NRZ9	Lymphoid-specific helicase	IDA	11532957	PubMed	PTHR10799:SF812	LYMPHOID-SPECIFIC HELICASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANAL|CGD=CAL0068551|UniProtKB=Q5AAR9	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MONDO|Ensembl=ENSMODG00000001807|UniProtKB=F6Y7R9	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	BOVIN|Ensembl=ENSBTAG00000020485|UniProtKB=P17870	Beta-arrestin-1	ISS	9388255	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	XENTR|Xenbase=XB-GENE-956713|UniProtKB=Q5XGD8	Guanine nucleotide binding protein, beta 3	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	IDA	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00005	Angiogenesis	P00251	cPLA2	HUMAN|HGNC=9037|UniProtKB=Q9UP65	Cytosolic phospholipase A2 gamma	ISS			PTHR10728:SF39	CYTOSOLIC PHOSPHOLIPASE A2 GAMMA
P00010	B cell activation	P00367	NFAT	PANTR|Ensembl=ENSPTRG00000008260|UniProtKB=H2QBD7	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	ISS	12787506	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04395	Vasopressin synthesis	P04594	Neurophysin	RAT|RGD=3238|UniProtKB=P01179	Oxytocin-neurophysin 1	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	RAT|RGD=1309329|UniProtKB=F1MAD0	Protein Lrp5	ISS	11029006	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	RAT|RGD=620195|UniProtKB=Q63341	Macrophage metalloelastase	TAS	12834808	PubMed	PTHR10201:SF32	MACROPHAGE METALLOELASTASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	ISS	11889126	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000023940|UniProtKB=F6RFW8	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	HUMAN|HGNC=10934|UniProtKB=P54219	Chromaffin granule amine transporter	ISS	11443533	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00057	Wnt signaling pathway	P01428	Frizzled	MOUSE|MGI=MGI=108476|UniProtKB=Q61086	Frizzled-3	IDA	11212302	PubMed	PTHR11309:SF22	FRIZZLED-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	TAKRU|Ensembl=ENSTRUG00000016101|UniProtKB=H2UW32	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00029	Huntington disease	P00774	Dynein complex	SCHPO|PomBase=SPAC1093.06c|UniProtKB=O13290	Dynein heavy chain, cytoplasmic	IPI	9454836	PubMed	PTHR10676:SF314	CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	MOUSE|MGI=MGI=95816|UniProtKB=B1AS29	Glutamate receptor ionotropic, kainate 3	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-9966|UniProtKB=Q6TH03	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IGI	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00059	p53 pathway	P04609	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01300	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05913	Enkephalin release	P05974	G-Protein (i)	MACMU|Ensembl=ENSMMUG00000014807|UniProtKB=F6W548	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00007	Axon guidance mediated by semaphorins	P00340	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12912997	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00019	Endothelin signaling pathway	P00574	Big ET1-4	MACMU|Ensembl=ENSMMUG00000016214|UniProtKB=F7GJV6	Uncharacterized protein	ISS	12516960	PubMed	PTHR13874:SF9	ENDOTHELIN-2
P00019	Endothelin signaling pathway	P00589	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06007	alpha-MSH	HUMAN|HGNC=9201|UniProtKB=P01189	Pro-opiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00030	Hypoxia response via HIF activation	P00823	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	ISS	96009592	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00236	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	ISS			PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00047	PDGF signaling pathway	P01162	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	IC	11889126	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00048	PI3 kinase pathway	P01179	PKB	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01175	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	10982827	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P04393	Ras Pathway	P04553	PAK	CHICK|Ensembl=ENSGALG00000006426|UniProtKB=E1BS97	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P05918	p38 MAPK pathway	P06031	p38alpha	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	MYCTU|EnsemblGenome=Rv1336|UniProtKB=P9WP53	O-phosphoserine sulfhydrylase	ISS			PTHR10314:SF136	SUBFAMILY NOT NAMED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	XENTR|Xenbase=XB-GENE-480347|UniProtKB=Q6P640	Actin, alpha cardiac muscle 1	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	MONDO|Ensembl=ENSMODG00000003244|UniProtKB=F6THF0	Uncharacterized protein	ISS	97402517	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00023	General transcription regulation	P00660	RNA Polymerase II	PLAF7|EnsemblGenome=PFB0245c|UniProtKB=O96150	DNA-directed RNA polymerase II 16 kDa subunit, putative	ISS			PTHR21297:SF0	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB4
P00009	Axon guidance mediated by netrin	P00359	NFAT	RAT|RGD=1310749|UniProtKB=D3Z9H7	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	ISS	9133421	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	CHICK|Ensembl=ENSGALG00000015544|UniProtKB=P07341	Fructose-bisphosphate aldolase B	ISS	2985560	PubMed	PTHR11627:SF2	FRUCTOSE-BISPHOSPHATE ALDOLASE B
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00564	Rac	DICDI|dictyBase=DDB_G0276967|UniProtKB=Q9GPS3	Rho-related protein racF2	ISS			PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00012	Cadherin signaling pathway	P00465	TCF/LEF	MACMU|Ensembl=ENSMMUG00000020134|UniProtKB=F6U055	Uncharacterized protein	ISS	11266476	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DICDI|dictyBase=DDB_G0279413|UniProtKB=P05987	cAMP-dependent protein kinase regulatory subunit	IC	91072385	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	DANRE|ZFIN=ZDB-GENE-030131-3776|UniProtKB=E7FC59	Uncharacterized protein	ISS			PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	ARATH|TAIR=AT5G07880|UniProtKB=Q9SD96	SNAP25 homologous protein SNAP29	IC			PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01331	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00049	Parkinson disease	P01242	Casein kinase I	CANLF|Ensembl=ENSCAFG00000006059|UniProtKB=F1Q126	Uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02772	Pyruvate metabolism	P03139	Lactate Dehydrogenase	TRIVA|Gene=TVAG_455680|UniProtKB=A2G057	Lactate dehydrogenase isozyme 2, putative	IDA	10339579	PubMed	PTHR23382:SF0	MALATE DEHYDROGENASE 2, MITOCHONDRIAL-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00012	Cadherin signaling pathway	P00471	Cadherin	BOVIN|Ensembl=ENSBTAG00000032092|UniProtKB=A2VDQ6	Cadherin 11, type 2, OB-cadherin (Osteoblast)	ISS	8120095	PubMed	PTHR24027:SF85	CADHERIN-11
P00010	B cell activation	P00402	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	HUMAN|HGNC=132|UniProtKB=P60709	Actin, cytoplasmic 1	IC	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DICDI|dictyBase=DDB_G0269234|UniProtKB=P07830	Major actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04558	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00048	PI3 kinase pathway	P01185	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05916	Opioid prodynorphin pathway	P06002	G-protein	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MOUSE|MGI=MGI=1333797|UniProtKB=O54689	C-C chemokine receptor type 6	IDA	11254677	PubMed	PTHR10489:SF611	C-C CHEMOKINE RECEPTOR TYPE 6
P02738	De novo purine biosynthesis	P02902	ADP reductase	MONDO|Ensembl=ENSMODG00000014763|UniProtKB=F7GGT3	Uncharacterized protein	ISS			PTHR23409:SF20	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00005	Angiogenesis	P00238	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00021	FGF signaling pathway	P00624	14-3-3	RAT|RGD=62002|UniProtKB=P61983	14-3-3 protein gamma	ISS	99360936	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000003043|UniProtKB=P63212	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	XENTR|Xenbase=XB-GENE-961764|UniProtKB=F6W3Y0	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MONDO|Ensembl=ENSMODG00000013079|UniProtKB=F7FB74	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00054	Toll receptor signaling pathway	P01368	MKK2	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P06587	Nicotine pharmacodynamics pathway	P06602	PPP1CA	BOVIN|Gene=PPP1CB|UniProtKB=Q3SWW9	Serine/threonine-protein phosphatase PP1-beta catalytic subunit	ISS	8392016	PubMed	PTHR11668:SF282	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-BETA CATALYTIC SUBUNIT
P00021	FGF signaling pathway	P00644	p38	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	IGI	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P02751	Lysine biosynthesis	P03013	Aspartate semialdehyde dehydrogenase	ARATH|TAIR=AT1G01630|UniProtKB=Q9LQ96	Polyphosphoinositide binding protein, putative	ISS			PTHR10174:SF198	BINDING PROTEIN, PUTATIVE-RELATED
P00019	Endothelin signaling pathway	P00590	IP3 R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00034	Integrin signalling pathway	P00925	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00056	VEGF signaling pathway	P01417	Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00029	Huntington disease	P00776	c-Jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P05916	Opioid prodynorphin pathway	P06002	G-protein	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00059	p53 pathway	P01485	p53	BOVIN|Ensembl=ENSBTAG00000001069|UniProtKB=P67939	Cellular tumor antigen p53	TAS	14744434	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_114976|UniProtKB=C3YP58	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000012820|UniProtKB=F1MDL3	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P04398	p53 pathway feedback loops 2	P04657	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00059	p53 pathway	P04633	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00049	Parkinson disease	P01236	Casein kinase II	PANTR|Ensembl=ENSPTRG00000013147|UniProtKB=H2QJS7	Uncharacterized protein	ISS	10617630	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00018	EGF receptor signaling pathway	P00551	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MOUSE|MGI=MGI=103011|UniProtKB=P47774	C-C chemokine receptor type 7	IDA	12133980	PubMed	PTHR10489:SF635	C-C CHEMOKINE RECEPTOR TYPE 7
P02775	Salvage pyrimidine ribonucleotides	P03150	Uridine kinase	HUMAN|HGNC=14859|UniProtKB=Q9HA47	Uridine-cytidine kinase 1	ISS			PTHR10285:SF66	URIDINE-CYTIDINE KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06849	Sos	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	RCA	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=103077|UniProtKB=Q64704	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00009	Axon guidance mediated by netrin	P00359	NFAT	MACMU|Ensembl=ENSMMUG00000003370|UniProtKB=F7E8G2	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P02741	Flavin biosynthesis	P02934	Riboflavin kinase	BACSU|EnsemblGenome=BSU16670|UniProtKB=P54575	Riboflavin biosynthesis protein RibC	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P00048	PI3 kinase pathway	P01177	P110ACT	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05913	Enkephalin release	P05972	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00021	FGF signaling pathway	P00633	Ras	DICPU|Gene=DICPUDRAFT_51488|UniProtKB=F1A411	Putative uncharacterized protein rasC	ISS	8290260	PubMed	PTHR24070:SF251	RAS-LIKE PROTEIN RASC
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MACMU|Ensembl=ENSMMUG00000020084|UniProtKB=F7GP56	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF427	MYOSIN-3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00059	p53 pathway	P01486	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=1351339|UniProtKB=Q14BI2	Metabotropic glutamate receptor 2	ISS	9407094	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00035	Interferon-gamma signaling pathway	P00959	IFNGR1	MACMU|Ensembl=ENSMMUG00000012098|UniProtKB=F7HB25	Interferon gamma receptor 1	ISS	14525967	PubMed	PTHR20859:SF5	INTERFERON GAMMA RECEPTOR 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BRAFL|Gene=BRAFLDRAFT_220697|UniProtKB=C3ZSF0	Putative uncharacterized protein	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P02737	Cysteine biosynthesis	P02888	Serine acetyltransferase	BACSU|EnsemblGenome=BSU00930|UniProtKB=Q06750	Serine acetyltransferase	ISS			PTHR42811:SF5	SERINE ACETYLTRANSFERASE 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04665	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00054	Toll receptor signaling pathway	P01369	MKK1	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TRIAD|EnsemblGenome=TriadG49626|UniProtKB=B3RKR4	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00059	p53 pathway	P04609	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	10799299	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00030	Hypoxia response via HIF activation	P00819	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00020	FAS signaling pathway	P00615	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	TAS	12040174	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P05913	Enkephalin release	P05972	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05731	GABA-B receptor II signaling	P05758	K channel	XENTR|Xenbase=XB-GENE-1004371|UniProtKB=F6R882	Uncharacterized protein	ISS	12374786	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	BOVIN|Ensembl=ENSBTAG00000001067|UniProtKB=E1BAB4	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00380	fos	RAT|RGD=2626|UniProtKB=P12841	Proto-oncogene c-Fos	TAS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=620146|UniProtKB=O08874	Serine/threonine-protein kinase N2	ISS	10644715	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00012	Cadherin signaling pathway	P00474	Wnt	XENTR|Xenbase=XB-GENE-492636|UniProtKB=F7D1A1	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01167	Ets	PANTR|Ensembl=ENSPTRG00000016449|UniProtKB=H2QQ65	E74-like factor 2 (Ets domain transcription factor)	ISS	15298723	PubMed	PTHR11849:SF10	ETS-RELATED TRANSCRIPTION FACTOR ELF-2
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=1310389|UniProtKB=D3ZTF6	Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Predicted), isoform CRA_a	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MOUSE|MGI=MGI=1338946|UniProtKB=Q61288	Serine/threonine-protein kinase receptor R3	TAS	9395284	PubMed	PTHR23255:SF66	SERINE/THREONINE-PROTEIN KINASE RECEPTOR R3
P00010	B cell activation	P00383	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00807	Actin	BOVIN|Ensembl=ENSBTAG00000014614|UniProtKB=P62739	Actin, aortic smooth muscle	ISS	3487386	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00034	Integrin signalling pathway	P00927	Rac	DICDI|dictyBase=DDB_G0293526|UniProtKB=P34149	Rho-related protein racC	IGI	8649368	PubMed	PTHR24072:SF117	RHO-RELATED PROTEIN RACC
P04396	Vitamin D metabolism and pathway	P04600	DBP	CHICK|Ensembl=ENSGALG00000011612|UniProtKB=F1NVF3	Uncharacterized protein	IPI	11799400	PubMed	PTHR11385:SF11	VITAMIN D-BINDING PROTEIN
P00060	Ubiquitin proteasome pathway	P01490	E3	BOVIN|Ensembl=ENSBTAG00000018421|UniProtKB=A3KMV3	E3 ligase WWP2	ISS			PTHR11254:SF396	NEDD4-LIKE E3 UBIQUITIN-PROTEIN LIGASE WWP2
P00059	p53 pathway	P01486	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01161	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	RAT|RGD=61916|UniProtKB=Q08463	Frizzled-1	TAS	12549854	PubMed	PTHR11309:SF81	FRIZZLED-1
P00019	Endothelin signaling pathway	P00589	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	9199552	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00053	T cell activation	P01300	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00774	Dynein complex	DROME|FlyBase=FBgn0033687|UniProtKB=A1Z8T9	CG8407, isoform A	IPI	9454836	PubMed	PTHR11886:SF2	DYNEIN LIGHT CHAIN 4, AXONEMAL
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	IDA	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02730	Asparagine and aspartate biosynthesis	P02853	Asparagine synthetase	METAC|EnsemblGenome=MA_1966|UniProtKB=Q8TPE7	Asparagine synthase (Glutamine-hydrolyzing)	ISS			PTHR11772:SF2	ASPARAGINE SYNTHETASE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04393	Ras Pathway	P04570	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	TAKRU|Ensembl=ENSTRUG00000004787|UniProtKB=P53480	Actin, alpha cardiac	ISS	11889126	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00046	Oxidative stress response	P01129	JNK1/2	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	TAS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00056	VEGF signaling pathway	P01425	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00011	Blood coagulation	P00415	Plasmin	MOUSE|MGI=MGI=97620|UniProtKB=P20918	Plasminogen	ISS	11928811	PubMed	PTHR24261:SF5	PLASMINOGEN
P00053	T cell activation	P01316	MHC-antigen	PANTR|Ensembl=ENSPTRG00000018029|UniProtKB=H2QSS4	Uncharacterized protein	ISS	73139	PubMed	PTHR19944:SF64	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DP ALPHA 1 CHAIN
P00047	PDGF signaling pathway	P01145	c-fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00035	Interferon-gamma signaling pathway	P00954	Interferongamma	BOVIN|Ensembl=ENSBTAG00000012529|UniProtKB=P07353	Interferon gamma	TAS	11929133	PubMed	PTHR11419:SF0	INTERFERON GAMMA
P00009	Axon guidance mediated by netrin	P00364	cdc42	TAKRU|Ensembl=ENSTRUG00000013411|UniProtKB=H2UB84	Uncharacterized protein	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00005	Angiogenesis	P00256	PLC-gamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05916	Opioid prodynorphin pathway	P06002	G-protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05734	Synaptic vesicle trafficking	P05777	Synaptophysin	MOUSE|MGI=MGI=98467|UniProtKB=Q62277	Synaptophysin	ISS	313475	OMIM	PTHR10306:SF10	SYNAPTOPHYSIN
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000025240|UniProtKB=F7A7I3	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00030	Hypoxia response via HIF activation	P00824	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00047	PDGF signaling pathway	P01143	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	97102671	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00049	Parkinson disease	P01212	p38 MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00020	FAS signaling pathway	P00615	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00021	FGF signaling pathway	P00629	PP2A	MOUSE|MGI=MGI=1349473|UniProtKB=Q61151	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	ISS	8703017	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00057	Wnt signaling pathway	P01435	SWI/SNF	CAEEL|WormBase=WBGene00016868|UniProtKB=Q22944	Uncharacterized protein	IDA	11532957	PubMed	PTHR10799:SF946	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MACMU|Ensembl=ENSMMUG00000009600|UniProtKB=F7AC65	Uncharacterized protein	ISS	2255909	PubMed	PTHR11920:SF291	ADENYLATE CYCLASE TYPE 3
P00018	EGF receptor signaling pathway	P00546	GAP	CANLF|Ensembl=ENSCAFG00000018592|UniProtKB=F1PIZ0	Uncharacterized protein	ISS	90304909	PubMed	PTHR10194:SF60	NEUROFIBROMIN
P00036	Interleukin signaling pathway	P00983	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01318	PKC-theta	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04398	p53 pathway feedback loops 2	P04661	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	11292874	PubMed	PTHR10048:SF14	PI-3 KINASE
P00005	Angiogenesis	P00216	Caspase 9	MACMU|Ensembl=ENSMMUG00000018163|UniProtKB=F7FNC1	Caspase	ISS	9390557	PubMed	PTHR10454:SF157	CASPASE-9
P05734	Synaptic vesicle trafficking	P05774	NSF	MOUSE|MGI=MGI=104560|UniProtKB=P46460	Vesicle-fusing ATPase	TAS	601633	OMIM	PTHR23078:SF3	VESICLE-FUSING ATPASE
P05915	Opioid proenkephalin pathway	P05995	proenkephalin	XENTR|Xenbase=XB-GENE-942760|UniProtKB=F6Y5F6	Uncharacterized protein	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P05916	Opioid prodynorphin pathway	P06001	AC	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	ISS	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CHICK|GeneID=431043|UniProtKB=P09652	Tubulin beta-4 chain	ISS	9454836	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IDA	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00006	Apoptosis signaling pathway	P00273	p53	RAT|RGD=3889|UniProtKB=P10361	Cellular tumor antigen p53	ISS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00003	Alzheimer disease-amyloid secretase pathway	P00101	BACE-1	MONDO|Ensembl=ENSMODG00000013692|UniProtKB=F6QP52	Uncharacterized protein	ISS	10531052	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00629	PP2A	ORNAN|Ensembl=ENSOANG00000008492|UniProtKB=F6XL57	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04552	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00054	Toll receptor signaling pathway	P01358	ERK1	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00774	Dynein complex	ANOGA|EnsemblGenome=AGAP000320|UniProtKB=Q7QF61	AGAP000320-PA	IPI	9454836	PubMed	PTHR12442:SF22	CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN 2
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01284	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00778	NMDA receptor	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P02746	Heme biosynthesis	P02972	Ferrochelatase	MACMU|Ensembl=ENSMMUG00000022568|UniProtKB=F6ZKY9	Ferrochelatase	ISS			PTHR11108:SF1	FERROCHELATASE, MITOCHONDRIAL
P00050	Plasminogen activating cascade	P01252	MMP-1	BOVIN|Gene=MMP1|UniProtKB=P28053	Interstitial collagenase	ISS	12834808	PubMed	PTHR10201:SF151	INTERSTITIAL COLLAGENASE
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01311	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IDA	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01202	p85	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ARATH|TAIR=AT2G42090|UniProtKB=P93738	Putative actin-9	IC	14684598	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P02781	Threonine biosynthesis	P03190	Threonine synthase	SULSO|EnsemblGenome=SSO0878|UniProtKB=Q97ZL6	Threonine synthase	ISS	11427726	PubMed	PTHR10314:SF5	THREONINE SYNTHASE 1, CHLOROPLASTIC
P00056	VEGF signaling pathway	P01414	PLC-gamma	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	STRPU|EnsemblGenome=SPU_005033|UniProtKB=W4XNQ0	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF263	SUBFAMILY NOT NAMED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	DROME|FlyBase=FBgn0264000|UniProtKB=M9PHV5	Glutamate receptor IB, isoform B	IC	12941441	PubMed	PTHR18966:SF270	GLUTAMATE RECEPTOR 1-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	CANLF|Ensembl=ENSCAFG00000004381|UniProtKB=J9JH96	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00053	T cell activation	P01312	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00047	PDGF signaling pathway	P01153	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P02725	Allantoin degradation	P02822	Allantoinase	BACSU|EnsemblGenome=BSU32410|UniProtKB=O32137	Allantoinase	ISS			PTHR43668:SF2	ALLANTOINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00034	Integrin signalling pathway	P00923	Arf1	PANTR|Ensembl=ENSPTRG00000002066|UniProtKB=G2HIU2	ADP-ribosylation factor 1	ISS	11752622	PubMed	PTHR11711:SF234	ADP-RIBOSYLATION FACTOR 1
P05730	Endogenous cannabinoid signaling	P05751	Galpha	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	HUMAN|HGNC=1388|UniProtKB=O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	11976940	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00060	Ubiquitin proteasome pathway	P01491	E2	MOUSE|MGI=MGI=1858216|UniProtKB=P61087	Ubiquitin-conjugating enzyme E2 K	ISS			PTHR44020:SF2	UBIQUITIN-CONJUGATING ENZYME E2 K
P00029	Huntington disease	P00807	Actin	XENTR|Xenbase=XB-GENE-493937|UniProtKB=Q5M8T9	Actin, alpha 2, smooth muscle, aorta	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00049	Parkinson disease	P01242	Casein kinase I	PANTR|Ensembl=ENSPTRG00000017401|UniProtKB=H2R587	Casein kinase 1, alpha 1	ISS	11437445	PubMed	PTHR11909:SF84	CASEIN KINASE I ISOFORM ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00208	MEKK1	PANTR|Ensembl=ENSPTRG00000016891|UniProtKB=H2R5K3	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00021	FGF signaling pathway	P00632	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00020	FAS signaling pathway	P00600	PARP	PANTR|Ensembl=ENSPTRG00000006089|UniProtKB=H2Q7V9	Poly [ADP-ribose] polymerase	ISS	12101391	PubMed	PTHR10459:SF60	POLY  ADP-RIBOSE  POLYMERASE 2
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	MOUSE|MGI=MGI=88274|UniProtKB=P26231	Catenin alpha-1	TAS	1768802	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04393	Ras Pathway	P04546	GSK3	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00019	Endothelin signaling pathway	P00566	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00059	p53 pathway	P04609	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00049	Parkinson disease	P01230	Src kinase	RAT|RGD=2994|UniProtKB=Q01621	Proto-oncogene tyrosine-protein kinase LCK	ISS	11078745	PubMed	PTHR24418:SF39	TYROSINE-PROTEIN KINASE LCK
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P04393	Ras Pathway	P04542	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00877	MLCK	PANTR|Ensembl=ENSPTRG00000013361|UniProtKB=H2QK55	Uncharacterized protein	ISS	600922	OMIM	PTHR45210:SF1	MYOSIN LIGHT CHAIN KINASE 2, SKELETAL/CARDIAC MUSCLE
P00005	Angiogenesis	P00206	Wnt	MACMU|Ensembl=ENSMMUG00000015705|UniProtKB=F6SM00	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IDA	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P05913	Enkephalin release	P05974	G-Protein (i)	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00005	Angiogenesis	P00225	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	RCA			PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	TAS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01444	Wnt	DANRE|ZFIN=ZDB-GENE-051129-1|UniProtKB=Q4JLT0	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00023	General transcription regulation	P00660	RNA Polymerase II	MACMU|Ensembl=ENSMMUG00000006987|UniProtKB=F7DQJ5	DNA-directed RNA polymerases I, II, and III subunit RPABC2	ISS	415387	gi	PTHR10773:SF12	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2
P04393	Ras Pathway	P04552	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	ANOGA|Gene=AgaP_AGAP009115|UniProtKB=Q7PW25	Phosphoinositide phospholipase C (Fragment)	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P04393	Ras Pathway	P04572	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00034	Integrin signalling pathway	P00907	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	CHICK|Ensembl=ENSGALG00000008058|UniProtKB=F1N8W8	Uncharacterized protein	ISS	11259591	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00019	Endothelin signaling pathway	P00568	PKC	CANAL|CGD=CAL0003231|UniProtKB=Q5ANK2	Protein kinase C	IGI	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CANLF|Ensembl=ENSCAFG00000016020|UniProtKB=O18840	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00034	Integrin signalling pathway	P00922	Collagen	HUMAN|HGNC=2216|UniProtKB=P25067	Collagen alpha-2(VIII) chain	IDA	10778855	PubMed	PTHR44057:SF3	COLLAGEN ALPHA-2 VIII  CHAIN
P00029	Huntington disease	P00778	NMDA receptor	RAT|RGD=2739|UniProtKB=Q00961	Glutamate receptor ionotropic, NMDA 2C	IDA	11319238	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01199	Galpha	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC			PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00379	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00049	Parkinson disease	P01238	14-3-3	XENTR|Xenbase=XB-GENE-970616|UniProtKB=Q6P4Z5	14-3-3 protein zeta	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	PANTR|Ensembl=ENSPTRG00000002062|UniProtKB=H2Q194	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	DROME|FlyBase=FBgn0004087|UniProtKB=P17719	Dihydrofolate reductase	ISS			PTHR22778:SF16	DIHYDROFOLATE REDUCTASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00045	Notch signaling pathway	P01114	Ntm	MACMU|Ensembl=ENSMMUG00000017022|UniProtKB=F7HQZ9	Uncharacterized protein	ISS	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MONDO|Ensembl=ENSMODG00000008086|UniProtKB=F6YJ34	Ribosomal protein S6 kinase	ISS	2779569	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P05916	Opioid prodynorphin pathway	P06002	G-protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	XENTR|Xenbase=XB-GENE-6035431|UniProtKB=F6RJ06	Uncharacterized protein	ISS	15328036	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8692|UniProtKB=Q9Y5E2	Protocadherin beta-7	IDA	8120095	PubMed	PTHR24028:SF69	PROTOCADHERIN BETA-7
P00029	Huntington disease	P00811	Arp2/3 complex	CHICK|Ensembl=ENSGALG00000004693|UniProtKB=Q5ZJI7	Uncharacterized protein	ISS	12963527	gi	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00047	PDGF signaling pathway	P01151	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00796	Kainate receptor	HUMAN|HGNC=4579|UniProtKB=P39086	Glutamate receptor ionotropic, kainate 1	IDA	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MACMU|Ensembl=ENSMMUG00000017339|UniProtKB=F7HBG6	Uncharacterized protein	ISS			PTHR11584:SF363	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 15
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	10799299	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00038	JAK/STAT signaling pathway	P01031	PIAS	RAT|RGD=1308737|UniProtKB=B5DFF9	Pias4 protein	ISS	8682149	PubMed	PTHR10782:SF9	E3 SUMO-PROTEIN LIGASE PIAS4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	GIAIC|EnsemblGenome=GL50803_7309|UniProtKB=E2RTQ4	Syntaxin-like protein 1	IC			PTHR19957:SF7	SYNTAXIN VAM3
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CHICK|Ensembl=ENSGALG00000008898|UniProtKB=F1P2J9	Uncharacterized protein	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	HUMAN|HGNC=4586|UniProtKB=Q13224	Glutamate receptor ionotropic, NMDA 2B	IC	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	9754712	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00048	PI3 kinase pathway	P01188	Gbetagamma	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P02729	Ascorbate degradation	P02851	L-ribulose-5-phosphate-4-epimerase	ECOLI|EcoGene=EG12498|UniProtKB=P39306	L-ribulose-5-phosphate 4-epimerase UlaF	ISS			PTHR22789:SF9	L-RIBULOSE-5-PHOSPHATE 4-EPIMERASE ULAF
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05731	GABA-B receptor II signaling	P05752	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	RCA	2303451	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01189	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P05731	GABA-B receptor II signaling	P05752	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00004	Alzheimer disease-presenilin pathway	P00141	Membrane metalloprotease	MACMU|Ensembl=ENSMMUG00000018206|UniProtKB=F7E951	Matrix metalloproteinase-24	RCA			PTHR10201:SF138	MATRIX METALLOPROTEINASE-24
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00887	IRS 1-4	HUMAN|HGNC=6128|UniProtKB=O14654	Insulin receptor substrate 4	ISS	5031805	gi	PTHR10614:SF2	INSULIN RECEPTOR SUBSTRATE 4
P04393	Ras Pathway	P04558	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P02741	Flavin biosynthesis	P02940	Riboflavin synthase	STRCO|Gene=CAC17561|UniProtKB=Q9EWJ6	Putative riboflavin synthase	ISS			PTHR21098:SF0	RIBOFLAVIN SYNTHASE
P00056	VEGF signaling pathway	P01421	Rac	MOUSE|MGI=MGI=2445003|UniProtKB=Q5FWK3	Rho GTPase-activating protein 1	ISS			PTHR23176:SF28	RHO GTPASE-ACTIVATING PROTEIN 1
P00029	Huntington disease	P00807	Actin	DICDI|dictyBase=DDB_G0275023|UniProtKB=Q553U6	Putative actin-22	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00034	Integrin signalling pathway	P00907	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00060	Ubiquitin proteasome pathway	P01492	E1	BOVIN|Ensembl=ENSBTAG00000006837|UniProtKB=F1ME38	Uncharacterized protein	ISS			PTHR10953:SF186	UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 6
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00219	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IC	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=109355|UniProtKB=O35526	Syntaxin-1A	ISS	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00036	Interleukin signaling pathway	P00965	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01457	GBeta	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00778	NMDA receptor	RAT|RGD=2740|UniProtKB=Q62645	Glutamate receptor ionotropic, NMDA 2D	IDA	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	RAT|RGD=2735|UniProtKB=Q63273	Glutamate receptor ionotropic, kainate 5	ISS	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00012	Cadherin signaling pathway	P00470	F-actin	USTMA|Gene=UMAG_11232|UniProtKB=A0A0D1DMT3	Chromosome 22, whole genome shotgun sequence	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04398	p53 pathway feedback loops 2	P04665	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	PANTR|Ensembl=ENSPTRG00000020739|UniProtKB=H2R6U6	Solute carrier family 1 (Neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	ISS	96032356	PubMed	PTHR11958:SF69	EXCITATORY AMINO ACID TRANSPORTER 3
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02771	Pyrimidine Metabolism	P03127	Beta-Ureidopropionase	MOUSE|MGI=MGI=2143535|UniProtKB=Q8VC97	Beta-ureidopropionase	IDA	8449931	PubMed	PTHR43674:SF2	BETA-UREIDOPROPIONASE
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	HUMAN|HGNC=6697|UniProtKB=O75197	Low-density lipoprotein receptor-related protein 5	IDA	11907044	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00005	Angiogenesis	P00189	Fzd	RAT|RGD=61916|UniProtKB=Q08463	Frizzled-1	ISS	12549854	PubMed	PTHR11309:SF81	FRIZZLED-1
P02751	Lysine biosynthesis	P03013	Aspartate semialdehyde dehydrogenase	BACTN|EnsemblGenome=BT_3636|UniProtKB=Q8A1M5	Aspartate-semialdehyde dehydrogenase	ISS			PTHR10174:SF2	ASPARTATE-SEMIALDEHYDE DEHYDROGENASE
P02772	Pyruvate metabolism	P03141	Citrate Synthetase	YEAST|SGD=S000005284|UniProtKB=P00890	Citrate synthase, mitochondrial	IPI	6090126	PubMed	PTHR11739:SF8	CITRATE SYNTHASE, MITOCHONDRIAL
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IC	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00236	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04559	Rac	BOVIN|Ensembl=ENSBTAG00000022927|UniProtKB=F1MCR0	Uncharacterized protein	ISS	15470041	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00034	Integrin signalling pathway	P00920	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	IC	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00165	E-cadherin N-terminal fragment	MACMU|Ensembl=ENSMMUG00000010393|UniProtKB=F7D992	Uncharacterized protein	ISS	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	RAT|RGD=71027|UniProtKB=P42264	Glutamate receptor ionotropic, kainate 3	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	HUMAN|HGNC=10483|UniProtKB=P21817	Ryanodine receptor 1	ISS	15858232	PubMed	PTHR13715:SF15	RYANODINE RECEPTOR 1
P00021	FGF signaling pathway	P00624	14-3-3	HUMAN|HGNC=12852|UniProtKB=P61981	14-3-3 protein gamma	IGI	99360936	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00005	Angiogenesis	P00211	GSK3beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00047	PDGF signaling pathway	P01168	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01177	P110ACT	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00780	Microtubule	PHYPA|Gene=PHYPADRAFT_223215|UniProtKB=Q6TYR8	Beta-tubulin 6	ISS	12932731	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00770	N-CoR	MOUSE|MGI=MGI=1337080|UniProtKB=Q9WU42	Nuclear receptor corepressor 2	IPI	10441327	PubMed	PTHR13992:SF21	NUCLEAR RECEPTOR COREPRESSOR 2
P00049	Parkinson disease	P01208	Hsp70	CANAL|CGD=CAL0001367|UniProtKB=Q5A397	Hsp75-like protein	IDA	12150907	PubMed	PTHR19375:SF256	HSP70 PROTEIN-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	ARATH|TAIR=AT4G02195|UniProtKB=Q9SWH4	Syntaxin-42	IC			PTHR19957:SF83	SYNTAXIN-16
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00019	Endothelin signaling pathway	P00589	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01440	Cadherin	CHICK|Gene=CDH4|UniProtKB=P24503	Cadherin-4	IDA	8120095	PubMed	PTHR24027:SF81	CADHERIN-4
P05731	GABA-B receptor II signaling	P05754	Ggamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	RCA	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00021	FGF signaling pathway	P00625	MKK3,6	HUMAN|HGNC=6843|UniProtKB=P46734	Dual specificity mitogen-activated protein kinase kinase 3	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00006	Apoptosis signaling pathway	P00274	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00056	VEGF signaling pathway	P01414	PLC-gamma	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	ARATH|TAIR=AT5G44100|UniProtKB=Q9FFH8	At5g44100	IDA	11437445	PubMed	PTHR11909:SF114	ADK1-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	STRPU|Gene=CYIIIA|UniProtKB=P53474	Actin, cytoskeletal 3A	IC	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00790	beta-Tubulin	ORNAN|Ensembl=ENSOANG00000003049|UniProtKB=F7B0P2	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00059	p53 pathway	P04623	CBP	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00163	Erb-B4 C-terminal fragment	MOUSE|MGI=MGI=104771|UniProtKB=Q61527	Receptor tyrosine-protein kinase erbB-4	ISS	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	CHICK|Ensembl=ENSGALG00000014268|UniProtKB=Q9PTS8	Neuronal acetylcholine receptor subunit alpha-9	IC			PTHR18945:SF489	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-9
P00019	Endothelin signaling pathway	P00589	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01414	PLC-gamma	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00005	Angiogenesis	P00249	PAK	RAT|RGD=61953|UniProtKB=Q64303	Serine/threonine-protein kinase PAK 2	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00018	EGF receptor signaling pathway	P00545	JNK1-3	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	11535291	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00017	DNA replication	P00527	Histones	MACMU|Ensembl=ENSMMUG00000021766|UniProtKB=F6QR30	Histone H3	ISS	20448842	PubMed	PTHR11426:SF179	HISTONE H3.3
P00019	Endothelin signaling pathway	P00586	Gq	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00049	Parkinson disease	P01239	Cul-1	MONDO|Ensembl=ENSMODG00000001825|UniProtKB=F6T584	Uncharacterized protein	ISS	12628165	PubMed	PTHR11932:SF81	CULLIN-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P02746	Heme biosynthesis	P02972	Ferrochelatase	SYNY3|EnsemblGenome=BAA10523|UniProtKB=P54225	Ferrochelatase	ISS			PTHR11108:SF1	FERROCHELATASE, MITOCHONDRIAL
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	PHYPA|Gene=PHYPADRAFT_210000|UniProtKB=A9S9L5	Predicted protein	ISS	7514101	PubMed	PTHR23050:SF245	AT16150P-RELATED
P02763	Peptidoglycan biosynthesis	P03088	UDP-N-acetylmuramate dehydrogenase	BACSU|EnsemblGenome=BSU15230|UniProtKB=P18579	UDP-N-acetylenolpyruvoylglucosamine reductase	ISS			PTHR21071:SF5	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00046	Oxidative stress response	P01124	Myc	CANLF|Gene=MYC|UniProtKB=Q28350	Myc proto-oncogene protein	TAS	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P02740	De novo pyrimidine ribonucleotides biosythesis	P02927	Dihydrooratate oxidase	PLAF7|EnsemblGenome=PFF0160c|UniProtKB=Q08210	Dihydroorotate dehydrogenase (quinone), mitochondrial	ISS			PTHR43517:SF1	DIHYDROOROTATE DEHYDROGENASE  QUINONE , MITOCHONDRIAL
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	IC	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00059	p53 pathway	P04630	PP2A	IXOSC|EnsemblGenome=ISCW014549|UniProtKB=B7QGY5	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PHYPA|Gene=PHYPADRAFT_109052|UniProtKB=A9TZ58	Actin 5	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00010	B cell activation	P00398	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00865	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	7798194	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BOVIN|Ensembl=ENSBTAG00000014614|UniProtKB=P62739	Actin, aortic smooth muscle	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00018	EGF receptor signaling pathway	P00545	JNK1-3	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00011	Blood coagulation	P00429	PN2	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00059	p53 pathway	P04616	PDK1/2	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	9094314	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00010	B cell activation	P00391	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00007	Axon guidance mediated by semaphorins	P00334	PlexinA1	MACMU|Ensembl=ENSMMUG00000016720|UniProtKB=F6VDJ2	Uncharacterized protein	ISS	10725340	PubMed	PTHR22625:SF35	PLEXIN-A1
P00048	PI3 kinase pathway	P01177	P110ACT	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	XENTR|Xenbase=XB-GENE-6469705|UniProtKB=Q6P8G3	Actin, alpha sarcomeric/skeletal	ISS	10974003	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00018	EGF receptor signaling pathway	P00551	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00054	Toll receptor signaling pathway	P01346	TLR	DROME|FlyBase=FBgn0036494|UniProtKB=Q9VUN0	Toll-like receptor 6	ISS			PTHR44740:SF2	TOLL-LIKE RECEPTOR 6
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00121	CD44 intracellular fragment	CHICK|Ensembl=ENSGALG00000007849|UniProtKB=F1NL98	Uncharacterized protein	IDA	12223485	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P00012	Cadherin signaling pathway	P00470	F-actin	ARATH|TAIR=AT3G18780|UniProtKB=Q96292	Actin-2	IC	10974003	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	CAEEL|WormBase=WBGene00003214|UniProtKB=P50432	Serine hydroxymethyltransferase	ISS			PTHR11680:SF21	SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC
P00047	PDGF signaling pathway	P01153	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00010	B cell activation	P00392	I kappa B	RAT|RGD=3171|UniProtKB=Q63746	NF-kappa-B inhibitor alpha	ISS	10869418	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00775	Rac	MONDO|Ensembl=ENSMODG00000003244|UniProtKB=F6THF0	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00057	Wnt signaling pathway	P01444	Wnt	MACMU|Ensembl=ENSMMUG00000020809|UniProtKB=F7H7P8	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04413	K+ channel	MACMU|Ensembl=ENSMMUG00000005826|UniProtKB=F6VE51	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00018	EGF receptor signaling pathway	P00556	PLCgamma	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	TAKRU|Ensembl=ENSTRUG00000014419|UniProtKB=H2UIU6	Uncharacterized protein	ISS	12473693	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00054	Toll receptor signaling pathway	P01352	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01063	CAT	RAT|RGD=1304627|UniProtKB=P32738	Choline O-acetyltransferase	IC	92155737	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P00029	Huntington disease	P00780	Microtubule	MACMU|Ensembl=ENSMMUG00000030028|UniProtKB=F7H0X2	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P00060	Ubiquitin proteasome pathway	P01490	E3	MOUSE|MGI=MGI=2140998|UniProtKB=Q80U95	Ubiquitin-protein ligase E3C	ISS			PTHR11254:SF357	UBIQUITIN-PROTEIN LIGASE E3C
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000005917|UniProtKB=F6QM53	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02736	Coenzyme A biosynthesis	P02884	Dephospho-CoA kinase	ANOGA|EnsemblGenome=AGAP004425|UniProtKB=Q7QA58	AGAP004425-PA	ISS			PTHR10695:SF35	DEPHOSPHO-COA KINASE DOMAIN-CONTAINING PROTEIN
P00003	Alzheimer disease-amyloid secretase pathway	P00087	Fe65	RAT|RGD=2122|UniProtKB=P46933	Amyloid beta A4 precursor protein-binding family B member 1	IDA	15115822	PubMed	PTHR14058:SF5	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	XENTR|Xenbase=XB-GENE-956713|UniProtKB=Q5XGD8	Guanine nucleotide binding protein, beta 3	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00023	General transcription regulation	P00660	RNA Polymerase II	METAC|EnsemblGenome=MA_1266|UniProtKB=Q8TRB4	DNA-directed RNA polymerase subunit H	ISS	11313498	PubMed	PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	TAS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01313	CD28	BOVIN|Gene=CD28|UniProtKB=Q28071	T-cell-specific surface glycoprotein CD28	ISS	7534617	PubMed	PTHR11494:SF7	T-CELL-SPECIFIC SURFACE GLYCOPROTEIN CD28
P05913	Enkephalin release	P05974	G-Protein (i)	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P02788	Xanthine and guanine salvage pathway	P03247	Xanthine phosphoribosyl transferase	TRYB2|Gene=Tb10.70.6650|UniProtKB=Q38CA0	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00020	FAS signaling pathway	P00600	PARP	MACMU|Ensembl=ENSMMUG00000021820|UniProtKB=F7EMW7	Poly [ADP-ribose] polymerase	ISS	12101391	PubMed	PTHR10459:SF80	POLY  ADP-RIBOSE  POLYMERASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00034	Integrin signalling pathway	P00922	Collagen	HUMAN|HGNC=2206|UniProtKB=P53420	Collagen alpha-4(IV) chain	IDA	10778855	PubMed	PTHR24023:SF714	COLLAGEN ALPHA-4 IV  CHAIN
P00057	Wnt signaling pathway	P01438	PP2A	BOVIN|Ensembl=ENSBTAG00000009245|UniProtKB=Q0P594	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01192	p110	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00627	ERK1-2	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00796	Kainate receptor	HUMAN|HGNC=4582|UniProtKB=Q16099	Glutamate receptor ionotropic, kainate 4	IDA	11319238	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P06664	Gonadotropin-releasing hormone receptor pathway	P06786	ERK1/2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	RCA	9298898	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MACMU|Ensembl=ENSMMUG00000004886|UniProtKB=F7AGT9	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00551	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00236	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=12775|UniProtKB=O00744	Protein Wnt-10b	IDA	8717036	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	DICDI|dictyBase=DDB_G0289117|UniProtKB=P34092	Myosin IB heavy chain	IC			PTHR13140:SF674	MYOSIN IB HEAVY CHAIN-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02775	Salvage pyrimidine ribonucleotides	P03152	Uridine phosphorylase	DROME|FlyBase=FBgn0039464|UniProtKB=Q9VBA0	CG6330, isoform A	ISS			PTHR43691:SF3	URIDINE PHOSPHORYLASE 1
P00021	FGF signaling pathway	P00628	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P02757	O-antigen biosynthesis	P03047	dTDP-4-dehydrorhamnose 3,5-epimerase	BACTN|EnsemblGenome=BT_1338|UniProtKB=Q8A836	dTDP-4-dehydrorhamnose 3,5-epimerase	ISS			PTHR21047:SF2	DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	176892	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=2683547|UniProtKB=Q4KWH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1	ISS	10934033	PubMed	PTHR10336:SF51	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00050	Plasminogen activating cascade	P01258	Fibrin C-terminal truncation	PANTR|Ensembl=ENSPTRG00000016535|UniProtKB=H2QQB5	Uncharacterized protein	ISS	4503689	gi	PTHR19143:SF232	FIBRINOGEN ALPHA CHAIN
P00029	Huntington disease	P00796	Kainate receptor	RAT|RGD=2733|UniProtKB=P42260	Glutamate receptor ionotropic, kainate 2	IDA	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-010705-1|UniProtKB=Q90Z40	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	15621031	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	MACMU|Ensembl=ENSMMUG00000006620|UniProtKB=F7H481	Uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF157	CASEIN KINASE I ISOFORM GAMMA-2
P00034	Integrin signalling pathway	P00925	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IDA	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	MOUSE|MGI=MGI=106213|UniProtKB=Q9R0W9	Neuronal acetylcholine receptor subunit alpha-6	ISS	85270494	PubMed	PTHR18945:SF82	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-6
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05913	Enkephalin release	P05972	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	RAT|RGD=68385|UniProtKB=D4A055	Calcium channel, voltage-dependent, beta 4 subunit, isoform CRA_b	IC			PTHR11824:SF7	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4
P00046	Oxidative stress response	P01131	MKP5	XENTR|Xenbase=XB-GENE-975056|UniProtKB=Q6GLD5	Dual specificity protein phosphatase	ISS			PTHR10159:SF309	DUAL SPECIFICITY PROTEIN PHOSPHATASE 1
P00054	Toll receptor signaling pathway	P01344	TRIF	MACMU|Ensembl=ENSMMUG00000014163|UniProtKB=F6YI17	Uncharacterized protein	ISS	22359180	PubMed	PTHR23213:SF331	SUBFAMILY NOT NAMED
P00059	p53 pathway	P04633	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	CANLF|Ensembl=ENSCAFG00000005449|UniProtKB=F1PNA9	TGF-beta receptor type-2	ISS	9759503	PubMed	PTHR23255:SF55	TGF-BETA RECEPTOR TYPE-2
P00036	Interleukin signaling pathway	P00981	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00034	Integrin signalling pathway	P00927	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CANLF|Ensembl=ENSCAFG00000028654|UniProtKB=J9P702	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P04392	P53 pathway feedback loops 1	P04539	p53	MACMU|Ensembl=ENSMMUG00000016569|UniProtKB=F6VXE7	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05918	p38 MAPK pathway	P06020	p38delta	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00736	CalDAG-GEF	RAT|RGD=1311630|UniProtKB=P0C643	RAS guanyl-releasing protein 2	ISS	10835426	PubMed	PTHR23113:SF16	RAS GUANYL-RELEASING PROTEIN 2
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95814|UniProtKB=Q60934	Glutamate receptor ionotropic, kainate 1	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	TRIAD|EnsemblGenome=TriadG37105|UniProtKB=B3RJX8	Calmodulin	ISS	10487978	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	TAS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	PANTR|Ensembl=ENSPTRG00000007084|UniProtKB=H2Q9G5	Uncharacterized protein	ISS	10051575	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	IDA	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00562	p38	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	4506785	gi	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	10395542	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00021	FGF signaling pathway	P00644	p38	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	4506785	gi	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=11333|UniProtKB=P31391	Somatostatin receptor type 4	IDA	12562507	PubMed	PTHR24229:SF52	SOMATOSTATIN RECEPTOR TYPE 4
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00037	Ionotropic glutamate receptor pathway	P01023	CaMKII	PANTR|Ensembl=ENSPTRG00000017414|UniProtKB=H2QRT0	Uncharacterized protein	ISS	10092204	PubMed	PTHR43940:SF5	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8703|UniProtKB=Q9Y5G8	Protocadherin gamma-A5	IDA	8120095	PubMed	PTHR24028:SF105	PROTOCADHERIN GAMMA-A5
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04586	ProTRH (Pro Thyrotropin-releasing Hormone)	HUMAN|HGNC=12298|UniProtKB=P20396	Pro-thyrotropin-releasing hormone	ISS	2126343	PubMed	PTHR17530:SF2	PRO-THYROTROPIN-RELEASING HORMONE
P04395	Vasopressin synthesis	P04593	Glycopeptide	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	IC	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P05918	p38 MAPK pathway	P06029	p38beta	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P05731	GABA-B receptor II signaling	P05752	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P02756	N-acetylglucosamine metabolism	P03041	Glucosamine-6-phosphate deaminase	MOUSE|MGI=MGI=1347054|UniProtKB=O88958	Glucosamine-6-phosphate isomerase 1	ISS			PTHR11280:SF8	GLUCOSAMINE-6-PHOSPHATE ISOMERASE 1
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000024992|UniProtKB=F6TUR3	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00003	Alzheimer disease-amyloid secretase pathway	P00101	BACE-1	PANTR|Ensembl=ENSPTRG00000004324|UniProtKB=H2Q4U8	Beta-site APP-cleaving enzyme 1	ISS	10531052	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	ARATH|TAIR=AT3G55940|UniProtKB=Q9LY51	Phosphoinositide phospholipase C 7	ISS			PTHR10336:SF92	PHOSPHOINOSITIDE PHOSPHOLIPASE C 2-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	IDA	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00054	Toll receptor signaling pathway	P01358	ERK1	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00545	JNK1-3	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00049	Parkinson disease	P01232	CASK	RAT|RGD=62004|UniProtKB=Q62915	Peripheral plasma membrane protein CASK	IPI	11679592	PubMed	PTHR23122:SF40	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00520	Rho GAPs	RAT|RGD=1306068|UniProtKB=D4A6C5	Protein Arhgap1	ISS	14724572	PubMed	PTHR23176:SF28	RHO GTPASE-ACTIVATING PROTEIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	ORNAN|Ensembl=ENSOANG00000010302|UniProtKB=F6TDQ6	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00034	Integrin signalling pathway	P00906	Rap1	MONDO|Ensembl=ENSMODG00000007323|UniProtKB=F7EFD0	Uncharacterized protein	ISS	8576107	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00005	Angiogenesis	P00254	GTPase	XENTR|Xenbase=XB-GENE-941426|UniProtKB=Q28HZ4	Novel Rho protein	ISS	12039949	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00006	Apoptosis signaling pathway	P00260	AKT	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	G04694	p110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00024	Glycolysis	P00676	Glyceraldehyde 3-phosphate dehydrogenase	ARATH|TAIR=AT3G26650|UniProtKB=P25856	Glyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic	RCA			PTHR43148:SF5	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE GAPA1, CHLOROPLASTIC-RELATED
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00645	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	IPI	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CANLF|Ensembl=ENSCAFG00000023338|UniProtKB=F1PKI6	Uncharacterized protein	ISS	10664585	PubMed	PTHR11462:SF7	TRANSCRIPTION FACTOR JUN-D
P00021	FGF signaling pathway	P00641	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00029	Huntington disease	G01529	Proline oxidase	ARATH|TAIR=AT5G38710|UniProtKB=Q6NKX1	Proline dehydrogenase 2, mitochondrial	NAS			PTHR13914:SF0	PROLINE DEHYDROGENASE 1, MITOCHONDRIAL
P00057	Wnt signaling pathway	P01471	alpha-catenin	MACMU|Ensembl=ENSMMUG00000000690|UniProtKB=F6YZM1	Uncharacterized protein	ISS	9362521	PubMed	PTHR18914:SF8	ALPHA-CATULIN
P00019	Endothelin signaling pathway	P00566	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	9298898	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00922	Collagen	BOVIN|Ensembl=ENSBTAG00000010175|UniProtKB=F1MJR6	Uncharacterized protein	ISS	10778855	PubMed	PTHR44057:SF3	COLLAGEN ALPHA-2 VIII  CHAIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00055	Transcription regulation by bZIP transcription factor	P01395	TFIIE	MACMU|Ensembl=ENSMMUG00000000459|UniProtKB=F6YR60	Transcription initiation factor IIE subunit beta	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P05918	p38 MAPK pathway	P06020	p38delta	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	12810719	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00260	AKT	CAEEL|WormBase=WBGene00000103|UniProtKB=Q9XTG7	Serine/threonine-protein kinase akt-2	ISS	12089061	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01126	ATF2	HUMAN|HGNC=784|UniProtKB=P15336	Cyclic AMP-dependent transcription factor ATF-2	TAS	10487205	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01444	Wnt	ORNAN|Gene=WNT2|UniProtKB=Q07DZ8	Protein Wnt-2	ISS	11266476	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00632	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MACMU|Ensembl=ENSMMUG00000020084|UniProtKB=F7GP56	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF427	MYOSIN-3
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	DANRE|Ensembl=ENSDARG00000070511|UniProtKB=E7F5R2	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF282	GLUTAMATE RECEPTOR-RELATED
P05916	Opioid prodynorphin pathway	P06002	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00029	Huntington disease	P00774	Dynein complex	PANTR|Ensembl=ENSPTRG00000008200|UniProtKB=H2QB99	Uncharacterized protein	ISS	9454836	PubMed	PTHR12688:SF1	CYTOPLASMIC DYNEIN 1 LIGHT INTERMEDIATE CHAIN 2
P00006	Apoptosis signaling pathway	P00274	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00049	Parkinson disease	P01239	Cul-1	CHICK|Ensembl=ENSGALG00000012402|UniProtKB=E1C0W8	Uncharacterized protein	ISS	12628165	PubMed	PTHR11932:SF81	CULLIN-1
P00018	EGF receptor signaling pathway	P00562	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00006	Apoptosis signaling pathway	P00297	NFkappaB	MOUSE|MGI=MGI=103290|UniProtKB=Q04207	Transcription factor p65	ISS			PTHR24169:SF1	TRANSCRIPTION FACTOR P65
P00034	Integrin signalling pathway	P00951	Jnk	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00644	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00030	Hypoxia response via HIF activation	P00819	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	TAS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00034	Integrin signalling pathway	P00912	Arp2/3	DROME|FlyBase=FBgn0001961|UniProtKB=O97182	Actin related complex p41 subunit	IPI	12473693	PubMed	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P00018	EGF receptor signaling pathway	P00539	14-3-3	MACMU|Ensembl=ENSMMUG00000013206|UniProtKB=F6XFG9	14-3-3 protein beta/alpha	ISS	12618428	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00034	Integrin signalling pathway	P00924	Raf	TAKRU|Ensembl=ENSTRUG00000006611|UniProtKB=H2SV11	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00990	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	XENTR|Xenbase=XB-GENE-494200|UniProtKB=F7CS79	Uncharacterized protein	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MOUSE|MGI=MGI=102891|UniProtKB=P51829	Adenylate cyclase type 7	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05918	p38 MAPK pathway	P06018	MNK1	MOUSE|MGI=MGI=894316|UniProtKB=O08605	MAP kinase-interacting serine/threonine-protein kinase 1	RCA	9155017	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	RCA	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00053	T cell activation	P01312	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04398	p53 pathway feedback loops 2	P04651	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P04397	p53 pathway by glucose deprivation	P04640	p53	BOVIN|Ensembl=ENSBTAG00000015460|UniProtKB=F1MKA9	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P05730	Endogenous cannabinoid signaling	P05751	Galpha	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00056	VEGF signaling pathway	P01411	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00010	B cell activation	P00373	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	MACMU|Ensembl=ENSMMUG00000009916|UniProtKB=F6YCP3	Uncharacterized protein	ISS			PTHR23359:SF102	ADENYLATE KINASE 8
P00045	Notch signaling pathway	P01109	Aph-1	HUMAN|HGNC=24080|UniProtKB=Q8WW43	Gamma-secretase subunit APH-1B	IDA	12110170	PubMed	PTHR12889:SF1	GAMMA-SECRETASE SUBUNIT APH-1B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	BOVIN|Ensembl=ENSBTAG00000014600|UniProtKB=E1BQ12	Uncharacterized protein	ISS	8163524	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00059	p53 pathway	P04633	P110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-478663|UniProtKB=F7EG64	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IDA	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00046	Oxidative stress response	P01136	Elk-1	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	TAS	10487205	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00047	PDGF signaling pathway	P01158	PDGF receptor A	HUMAN|HGNC=8803|UniProtKB=P16234	Platelet-derived growth factor receptor alpha	RCA			PTHR24416:SF52	PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA
P00059	p53 pathway	G01581	BAX	HUMAN|HGNC=959|UniProtKB=Q07812	Apoptosis regulator BAX	ISS	14963330	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IDA	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00029	Huntington disease	P00782	alpha-Adaptin	RAT|RGD=1306254|UniProtKB=D3ZUY8	Adaptor protein complex AP-2, alpha 1 subunit (Predicted)	ISS	11532990	PubMed	PTHR22780:SF19	AP-2 COMPLEX SUBUNIT ALPHA-1
P00029	Huntington disease	P00801	Fos protein	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	TAS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00018	EGF receptor signaling pathway	P00562	p38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	IGI	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00057	Wnt signaling pathway	P01444	Wnt	RAT|RGD=628850|UniProtKB=B1WBR9	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00046	Oxidative stress response	P01129	JNK1/2	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	TAS	22040490	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00006	Apoptosis signaling pathway	P00284	Flip	MOUSE|MGI=MGI=1336166|UniProtKB=O35732	CASP8 and FADD-like apoptosis regulator	ISS	8681376	PubMed	PTHR10454:SF8	CASP8 AND FADD-LIKE APOPTOSIS REGULATOR
P00057	Wnt signaling pathway	P01457	GBeta	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00056	VEGF signaling pathway	P01407	Erk	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CAEEL|WormBase=WBGene00004055|UniProtKB=Q17446	Mitogen-activated protein kinase pmk-1	IDA	11707292	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00034	Integrin signalling pathway	P00907	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04531	Oxytocin Receptor	HUMAN|HGNC=8529|UniProtKB=P30559	Oxytocin receptor	ISS	11006161	PubMed	PTHR24241:SF19	OXYTOCIN RECEPTOR
P00012	Cadherin signaling pathway	P00470	F-actin	DANRE|ZFIN=ZDB-GENE-030131-1229|UniProtKB=Q6DHS1	Actin, alpha 2, smooth muscle, aorta	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	ORNAN|Ensembl=ENSOANG00000015652|UniProtKB=F7FY70	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00060	Ubiquitin proteasome pathway	P01490	E3	MONDO|Ensembl=ENSMODG00000000974|UniProtKB=F7A2Q4	Uncharacterized protein	ISS			PTHR11254:SF301	UBIQUITIN-PROTEIN LIGASE E3A
P00059	p53 pathway	P04633	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	RAT|RGD=1304893|UniProtKB=D4ADE0	Protein Ccr8	ISS	11238588	PubMed	PTHR10489:SF627	C-C CHEMOKINE RECEPTOR TYPE 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	DROME|FlyBase=FBgn0004623|UniProtKB=P29829	Guanine nucleotide-binding protein subunit beta-2	ISS	10391901	PubMed	PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_115566|UniProtKB=C3XYC8	Putative uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P04397	p53 pathway by glucose deprivation	G04706	TSC2	HUMAN|HGNC=12363|UniProtKB=P49815	Tuberin	ISS	15249583	PubMed	PTHR10063:SF0	TUBERIN
P02779	Thiamin biosynthesis	P03170	Hydroxymethylpyrimidine phosphate kinase	YEAST|SGD=S000006325|UniProtKB=Q06490	Thiamine biosynthesis protein THI22	ISS			PTHR20858:SF17	HYDROXYMETHYLPYRIMIDINE/PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED
P00057	Wnt signaling pathway	P01440	Cadherin	DANRE|ZFIN=ZDB-GENE-020731-3|UniProtKB=E7FAU6	Uncharacterized protein	IDA			PTHR24028:SF230	SUBFAMILY NOT NAMED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00054	Toll receptor signaling pathway	P01360	IKKbeta	MACMU|Ensembl=ENSMMUG00000008351|UniProtKB=F7HRV5	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00047	PDGF signaling pathway	P01160	IP3 receptor	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01151	PKB	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01402	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	RCA			PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	ARATH|TAIR=AT5G07880|UniProtKB=Q9SD96	SNAP25 homologous protein SNAP29	IC			PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IDA	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	TAKRU|Ensembl=ENSTRUG00000007989|UniProtKB=P68140	Actin, alpha skeletal muscle A	IC	11889126	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00047	PDGF signaling pathway	P01171	PLCgamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	PANTR|Ensembl=ENSPTRG00000006218|UniProtKB=H2Q834	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	MOUSE|MGI=MGI=1924885|UniProtKB=Q9JLY0	Suppressor of cytokine signaling 6	TAS	12645661	PubMed	PTHR44562:SF1	SUPPRESSOR OF CYTOKINE SIGNALING 6
P00020	FAS signaling pathway	P00599	Caspase3	MACMU|Ensembl=ENSMMUG00000012053|UniProtKB=F7HFY2	Uncharacterized protein	ISS	9323209	PubMed	PTHR10454:SF198	CASPASE-3
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00029	Huntington disease	P00790	beta-Tubulin	XENTR|Xenbase=XB-GENE-491121|UniProtKB=Q6P367	Tubulin, beta 2B	ISS	12932731	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00059	p53 pathway	P01486	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00023	General transcription regulation	P00660	RNA Polymerase II	XENTR|Xenbase=XB-GENE-491031|UniProtKB=Q6DDA6	Polymerase (RNA) II (DNA directed) polypeptide F	ISS	415387	gi	PTHR10773:SF12	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2
P00053	T cell activation	P01300	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00047	PDGF signaling pathway	P01154	Ras	BOVIN|Ensembl=ENSBTAG00000002475|UniProtKB=Q3MHP2	Ras-related protein Rab-11B	ISS			PTHR24073:SF335	RAS-RELATED PROTEIN RAB-11B
P00048	PI3 kinase pathway	P01192	p110	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00388	PLC gamma2	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95816|UniProtKB=B1AS29	Glutamate receptor ionotropic, kainate 3	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MACMU|Ensembl=ENSMMUG00000017683|UniProtKB=F6UA63	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P05917	Opioid proopiomelanocortin pathway	P06007	alpha-MSH	MOUSE|MGI=MGI=97742|UniProtKB=P01193	Pro-opiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00005	Angiogenesis	P00182	p38MAPK	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00006	Apoptosis signaling pathway	P00271	Bax	MACMU|Ensembl=ENSMMUG00000003907|UniProtKB=F6ZV96	Apoptosis regulator BAX isoform alpha	ISS	11099028	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00010	B cell activation	P00371	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	MOUSE|MGI=MGI=97453|UniProtKB=P35454	Oxytocin-neurophysin 1	ISS	6717565	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	PANTR|Ensembl=ENSPTRG00000005858|UniProtKB=H2Q7J6	Uncharacterized protein	ISS	8143856	PubMed	PTHR24247:SF30	5-HYDROXYTRYPTAMINE RECEPTOR 2A
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00047	PDGF signaling pathway	P01162	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	TAKRU|Ensembl=ENSTRUG00000007912|UniProtKB=H2T4W3	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF83	PROTEIN WNT
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=2136759|UniProtKB=Q91V48	MCG1033322	IDA	8120095	PubMed	PTHR24028:SF98	PROTOCADHERIN BETA-18-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	HUMAN|HGNC=130|UniProtKB=P62736	Actin, aortic smooth muscle	IC	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	MACMU|Ensembl=ENSMMUG00000013998|UniProtKB=F6RRJ7	Adenylate kinase isoenzyme 1	ISS			PTHR23359:SF59	ADENYLATE KINASE ISOENZYME 1
P00050	Plasminogen activating cascade	P01254	pro-MMP-13	MACMU|Ensembl=ENSMMUG00000004253|UniProtKB=F6YQ28	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF165	COLLAGENASE 3
P00018	EGF receptor signaling pathway	P00564	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	P01428	Frizzled	MONDO|Ensembl=ENSMODG00000011428|UniProtKB=F6RKF7	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF34	FRIZZLED-2
P00006	Apoptosis signaling pathway	P00313	IKK	RAT|RGD=621375|UniProtKB=Q9QY78	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00057	Wnt signaling pathway	P01452	NFAT	CANLF|Ensembl=ENSCAFG00000011625|UniProtKB=F1PDD9	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	MOUSE|MGI=MGI=97576|UniProtKB=P18826	Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform	IDA	10487978	PubMed	PTHR10749:SF4	PHOSPHORYLASE B KINASE REGULATORY SUBUNIT ALPHA, SKELETAL MUSCLE ISOFORM
P00005	Angiogenesis	P00251	cPLA2	MACMU|Ensembl=ENSMMUG00000021423|UniProtKB=F7EEZ1	Phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	MACMU|Ensembl=ENSMMUG00000007427|UniProtKB=F6SX33	Rhodopsin kinase	ISS	8288567	PubMed	PTHR24355:SF11	RHODOPSIN KINASE
P00007	Axon guidance mediated by semaphorins	P00338	Neuropilin 1	PANTR|Ensembl=ENSPTRG00000002414|UniProtKB=H2Q1T2	Neuropilin 1	ISS	9288754	PubMed	PTHR44185:SF1	NEUROPILIN-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	RAT|RGD=2257|UniProtKB=P62161	Calmodulin	ISS	10487978	PubMed	PTHR23050:SF311	CALMODULIN
P00003	Alzheimer disease-amyloid secretase pathway	P00093	Tip60	RAT|RGD=621061|UniProtKB=Q99MK2	Histone acetyltransferase KAT5	ISS	11441186	PubMed	PTHR10615:SF124	HISTONE ACETYLTRANSFERASE KAT5
P04398	p53 pathway feedback loops 2	P04657	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	RCA	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00048	PI3 kinase pathway	P01177	P110ACT	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	IGI	11292874	PubMed	PTHR10048:SF14	PI-3 KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CAEBR|Gene=CBG02401|UniProtKB=A8WUE7	Protein CBR-NMR-1	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	DROME|FlyBase=FBgn0010194|UniProtKB=P28466	Protein Wnt-5	TAS	8717036	PubMed	PTHR12027:SF77	PROTEIN WNT-5
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	ISS	11256888	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MACMU|Ensembl=ENSMMUG00000007027|UniProtKB=F7F210	Alpha-cardiac actin	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00047	PDGF signaling pathway	P01148	Grb2	CAEEL|WormBase=WBGene00004774|UniProtKB=P29355	Sex muscle abnormal protein 5	ISS	4504111	gi	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00057	Wnt signaling pathway	P01471	alpha-catenin	BOVIN|Ensembl=ENSBTAG00000045699|UniProtKB=G3N018	Uncharacterized protein	ISS	9362521	PubMed	PTHR18914:SF21	CATENIN ALPHA-3
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00274	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	TAS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	CANLF|Gene=CGA|UniProtKB=Q9XSW8	Glycoprotein hormones alpha chain	ISS	15927770	PubMed	PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00313	IKK	MOUSE|MGI=MGI=99484|UniProtKB=Q60680	Inhibitor of nuclear factor kappa-B kinase subunit alpha	ISS	12235208	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00060	Ubiquitin proteasome pathway	P01491	E2	BOVIN|Ensembl=ENSBTAG00000023218|UniProtKB=Q3SZ43	Ubiquitin-conjugating enzyme E2 variant 2	ISS			PTHR43915:SF3	UBIQUITIN-CONJUGATING ENZYME E2 VARIANT 2
P00029	Huntington disease	P00807	Actin	CAEEL|WormBase=WBGene00000067|UniProtKB=O45815	ACTin	IDA	14684598	PubMed	PTHR11937:SF352	ACTIN
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	CAEBR|Gene=CBG18112|UniProtKB=A8XT20	Protein CBR-GLR-1	ISS	12941441	PubMed	PTHR18966:SF297	GLUTAMATE RECEPTOR 1
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	PANTR|Ensembl=ENSPTRG00000012427|UniProtKB=H2QIN7	Mitogen-activated protein kinase kinase kinase 2	ISS	11730323	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000010521|UniProtKB=F7DQK7	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	TAS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00801	Fos protein	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	TAS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00047	PDGF signaling pathway	P01148	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	15210125	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04395	Vasopressin synthesis	P04589	Signal Peptidase	MOUSE|MGI=MGI=1929464|UniProtKB=Q9R0P6	Signal peptidase complex catalytic subunit SEC11A	IC	2674115	PubMed	PTHR10806:SF8	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11A-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT4G01370|UniProtKB=Q39024	Mitogen-activated protein kinase 4	ISS	9836510	gi	PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P04398	p53 pathway feedback loops 2	P04658	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	DANRE|ZFIN=ZDB-GENE-000403-1|UniProtKB=P57094	Axin-1	IEP	9554852	PubMed	PTHR10845:SF11	AXIN-1
P00029	Huntington disease	P00786	ARF	MONDO|Ensembl=ENSMODG00000015229|UniProtKB=F6V2X8	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF308	ADP-RIBOSYLATION FACTOR 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	PANTR|Ensembl=ENSPTRG00000014748|UniProtKB=H2QMA4	Uncharacterized protein	ISS	3487386	PubMed	PTHR23220:SF69	INTEGRIN ALPHA-9
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00008	Axon guidance mediated by Slit/Robo	P00344	Netrin	MOUSE|MGI=MGI=1888978|UniProtKB=Q9JI33	Netrin-4	ISS	2538453	PubMed	PTHR10574:SF282	NETRIN-4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	MOUSE|MGI=MGI=96435|UniProtKB=Q07113	Cation-independent mannose-6-phosphate receptor	ISS	13642251	gi	PTHR15071:SF17	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
P00049	Parkinson disease	P01211	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CHICK|Ensembl=ENSGALG00000008898|UniProtKB=F1P2J9	Uncharacterized protein	IC	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	TAKRU|Ensembl=ENSTRUG00000007253|UniProtKB=H2SZQ1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MONDO|Ensembl=ENSMODG00000013970|UniProtKB=F6R6X5	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00006	Apoptosis signaling pathway	P00302	ATF	CHICK|Ensembl=ENSGALG00000009287|UniProtKB=O93602	Cyclic AMP-dependent transcription factor ATF-2	ISS	10207617	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00990	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P02772	Pyruvate metabolism	P03133	Pyruvate Dehydrogenase	MOUSE|MGI=MGI=97532|UniProtKB=P35486	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial	RCA			PTHR11516:SF51	PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA, SOMATIC FORM, MITOCHONDRIAL
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P02751	Lysine biosynthesis	P03011	N-succinyldiaminopimelate  aminotransferase	YEAST|SGD=S000005500|UniProtKB=P18544	Acetylornithine aminotransferase, mitochondrial	IDA			PTHR11986:SF79	ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL
P02728	Arginine biosynthesis	P02846	Ornithine carbamoyl transferase	ECOLI|EcoGene=EG10069|UniProtKB=P04391	Ornithine carbamoyltransferase chain I	ISS			PTHR11405:SF42	ORNITHINE CARBAMOYLTRANSFERASE CHAIN F-RELATED
P00053	T cell activation	P01322	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P05915	Opioid proenkephalin pathway	P05994	G-protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01192	p110	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00313	IKK	PANTR|Ensembl=ENSPTRG00000033948|UniProtKB=H2RBD4	Conserved helix-loop-helix ubiquitous kinase	ISS	12813046	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	ANOGA|EnsemblGenome=AGAP010324|UniProtKB=Q7PMQ2	AGAP010324-PA	ISS	9783586	PubMed	PTHR10814:SF24	TRANSDUCIN-LIKE ENHANCER PROTEIN 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	TAS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02730	Asparagine and aspartate biosynthesis	P02853	Asparagine synthetase	CANLF|Ensembl=ENSCAFG00000002222|UniProtKB=E2RF46	Uncharacterized protein	ISS			PTHR11772:SF23	ASPARAGINE SYNTHETASE  GLUTAMINE-HYDROLYZING
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04398	p53 pathway feedback loops 2	P04657	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00054	Toll receptor signaling pathway	P01375	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00047	PDGF signaling pathway	P01153	GSK3	ARATH|TAIR=AT1G06390|UniProtKB=Q39012	Shaggy-related protein kinase iota	ISS	12615961	PubMed	PTHR24057:SF12	SHAGGY-RELATED PROTEIN KINASE IOTA-RELATED
P00048	PI3 kinase pathway	P01199	Galpha	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01411	Ras	TAKRU|Ensembl=ENSTRUG00000005329|UniProtKB=H2SK54	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	7492337	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00047	PDGF signaling pathway	P01167	Ets	HUMAN|HGNC=3320|UniProtKB=Q9UKW6	ETS-related transcription factor Elf-5	ISS	15298723	PubMed	PTHR11849:SF15	ETS-RELATED TRANSCRIPTION FACTOR ELF-5
P02743	Formyltetrahydroformate biosynthesis	P02952	Methylene tetrahydrofolate dehydrogenase	HUMAN|HGNC=21055|UniProtKB=Q6UB35	Monofunctional C1-tetrahydrofolate synthase, mitochondrial	ISS			PTHR43274:SF3	MONOFUNCTIONAL C1-TETRAHYDROFOLATE SYNTHASE, MITOCHONDRIAL
P00005	Angiogenesis	P00203	Erk	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04542	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05913	Enkephalin release	P05977	G-Protein (s)	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF31	SUBFAMILY NOT NAMED
P00054	Toll receptor signaling pathway	P01369	MKK1	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00025	Hedgehog signaling pathway	P00699	Su(fu)	HUMAN|HGNC=16466|UniProtKB=Q9UMX1	Suppressor of fused homolog	IDA	10920228	PubMed	PTHR10928:SF2	SUPPRESSOR OF FUSED HOMOLOG
P00013	Cell cycle	P00489	CdkC	PANTR|Ensembl=ENSPTRG00000010782|UniProtKB=H2R677	Cyclin E1	RCA			PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	RAT|RGD=69319|UniProtKB=P54313	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	PANTR|Ensembl=ENSPTRG00000012575|UniProtKB=H2QIW0	Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14	ISS	9727008	PubMed	PTHR10410:SF5	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 14
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	IDA	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00009	Axon guidance mediated by netrin	P00363	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00003	Alzheimer disease-amyloid secretase pathway	P00091	Aph-1	MOUSE|MGI=MGI=3522097|UniProtKB=Q8C7N7	Gamma-secretase subunit APH-1B	IDA	12110170	PubMed	PTHR12889:SF1	GAMMA-SECRETASE SUBUNIT APH-1B
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000016097|UniProtKB=E1B9S9	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P06664	Gonadotropin-releasing hormone receptor pathway	P06786	ERK1/2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	RCA	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00005	Angiogenesis	P00211	GSK3beta	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	PANTR|Ensembl=ENSPTRG00000019407|UniProtKB=H2QUY0	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	PANTR|Ensembl=ENSPTRG00000019407|UniProtKB=H2QUY0	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00972	MNK1/2	MACMU|Ensembl=ENSMMUG00000020162|UniProtKB=F6TJV6	Uncharacterized protein	ISS	11575158	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00771	Sin3A	YARLI|EnsemblGenome=YALI0_D26315g|UniProtKB=F2Z640	YALI0D26315p	IDA	10441327	PubMed	PTHR12346:SF0	SIN3A, ISOFORM G
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IC	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05912	Dopamine receptor mediated signaling pathway	P05945	Gsalpha	CHICK|Ensembl=ENSGALG00000007509|UniProtKB=F1NM72	Uncharacterized protein	ISS	6309844	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	ENTHI|EnsemblGenome=EHI_197840|UniProtKB=C4M8K6	Rho family GTPase	ISS	8649368	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00029	Huntington disease	P00786	ARF	PRIPA|Gene=PPA05391|UniProtKB=H3E6Q9	ADP ribosylation factor	ISS	12932731	PubMed	PTHR11711:SF304	ADP-RIBOSYLATION FACTOR 1
P00035	Interferon-gamma signaling pathway	P00956	SOCS	MOUSE|MGI=MGI=1914546|UniProtKB=Q91ZA6	Suppressor of cytokine signaling 4	TAS	15032587	PubMed	PTHR44282:SF2	SUPPRESSOR OF CYTOKINE SIGNALING 4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=96274|UniProtKB=P28334	5-hydroxytryptamine receptor 1B	IDA	11454663	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00563	Gab	MACMU|Ensembl=ENSMMUG00000017477|UniProtKB=F6VIK2	Uncharacterized protein	ISS	16758156	gi	PTHR12156:SF4	GRB2-ASSOCIATED-BINDING PROTEIN 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MOUSE|MGI=MGI=87909|UniProtKB=P62737	Actin, aortic smooth muscle	IDA	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00012	Cadherin signaling pathway	P00470	F-actin	STRPU|EnsemblGenome=SPU_026078|UniProtKB=W4ZD41	Uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF277	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01428	Frizzled	PANTR|Ensembl=ENSPTRG00000004148|UniProtKB=H2Q4I6	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF23	FRIZZLED-4
P00037	Ionotropic glutamate receptor pathway	P01005	NR2D	RAT|RGD=2740|UniProtKB=Q62645	Glutamate receptor ionotropic, NMDA 2D	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00010	B cell activation	P00388	PLC gamma2	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00030	Hypoxia response via HIF activation	P00825	Thioredoxin	CAEEL|WormBase=WBGene00010160|UniProtKB=Q9TW67	Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase	ISS			PTHR12143:SF19	PEPTIDE-N 4 - N-ACETYL-BETA-GLUCOSAMINYL ASPARAGINE AMIDASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02772	Pyruvate metabolism	P03140	Pyruvate Carboxylase	MACMU|Ensembl=ENSMMUG00000004533|UniProtKB=F6SC45	Pyruvate carboxylase	ISS	8048912	PubMed	PTHR43778:SF2	PYRUVATE CARBOXYLASE, MITOCHONDRIAL
P00053	T cell activation	P01322	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	IGI	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00019	Endothelin signaling pathway	P00566	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01192	p110	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	HUMAN|HGNC=4598|UniProtKB=O15303	Metabotropic glutamate receptor 6	ISS	9407094	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00005	Angiogenesis	P00249	PAK	MOUSE|MGI=MGI=1339975|UniProtKB=O88643	Serine/threonine-protein kinase PAK 1	ISS	14580336	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00020	FAS signaling pathway	P00615	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	RAT|RGD=1564914|UniProtKB=D3ZUE4	Protein Socs5	ISS	22247722	PubMed	PTHR44282:SF3	SUPPRESSOR OF CYTOKINE SIGNALING 5
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00057	Wnt signaling pathway	P01446	Calcineurin	ANOGA|EnsemblGenome=AGAP001279|UniProtKB=Q7PKK6	Serine/threonine-protein phosphatase	ISS	12015605	PubMed	PTHR11668:SF118	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED
P00010	B cell activation	P00384	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	XENTR|Xenbase=XB-GENE-484032|UniProtKB=F6QWD3	Tyrosine-protein kinase receptor	ISS	249616	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00018	EGF receptor signaling pathway	P00549	EGF	MACMU|Ensembl=ENSMMUG00000017380|UniProtKB=F7H6N1	Uncharacterized protein	RCA			PTHR11100:SF18	PRO-NEUREGULIN-3, MEMBRANE-BOUND ISOFORM
P00011	Blood coagulation	P00414	Thrombin	RAT|RGD=61996|UniProtKB=P18292	Prothrombin	ISS	+176930	OMIM	PTHR24254:SF10	PROTHROMBIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	BOVIN|Ensembl=ENSBTAG00000014463|UniProtKB=Q2HJF7	Calcium/calmodulin-dependent protein kinase type II subunit delta	ISS	12888804	PubMed	PTHR43940:SF4	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT DELTA
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00047	PDGF signaling pathway	P01162	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00034	Integrin signalling pathway	P00944	Actin	MONDO|Ensembl=ENSMODG00000024992|UniProtKB=F6TUR3	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00021	FGF signaling pathway	P00638	PLCgamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IGI	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00005	Angiogenesis	P00233	CSL	PANTR|Ensembl=ENSPTRG00000015968|UniProtKB=H2R2Q6	Uncharacterized protein	ISS	12145413	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00029	Huntington disease	P00777	CBP	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	IDA	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	BOVIN|Ensembl=ENSBTAG00000005714|UniProtKB=Q3ZC07	Actin, alpha cardiac muscle 1	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00021	FGF signaling pathway	P00623	FGF	PANTR|Ensembl=ENSPTRG00000017361|UniProtKB=H2QRP4	Fibroblast growth factor	ISS	12799194	PubMed	PTHR11486:SF86	FIBROBLAST GROWTH FACTOR 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00030	Hypoxia response via HIF activation	P00819	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00018	EGF receptor signaling pathway	P00563	Gab	CANLF|Ensembl=ENSCAFG00000003613|UniProtKB=F1P7F6	Uncharacterized protein	ISS	4503851	gi	PTHR12156:SF18	GRB2-ASSOCIATED-BINDING PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00172	BACE-1	MOUSE|MGI=MGI=1346542|UniProtKB=P56818	Beta-secretase 1	IDA	10531052	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00005	Angiogenesis	P00209	FAK	RAT|RGD=3443|UniProtKB=O35346	Focal adhesion kinase 1	ISS	12640026	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00012	Cadherin signaling pathway	P00462	Casein kinase II	HUMAN|HGNC=2460|UniProtKB=P67870	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00053	T cell activation	P01306	Ras	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	IDA	12104050	PubMed	PTHR24070:SF189	GTPASE NRAS
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	STRPU|EnsemblGenome=SPU_018419|UniProtKB=W4YRI6	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00007	Axon guidance mediated by semaphorins	P00337	Sema3A	RAT|RGD=3657|UniProtKB=Q63548	Semaphorin-3A	ISS			PTHR11036:SF23	SEMAPHORIN-3A
P00057	Wnt signaling pathway	P01439	C-terminal Binding Protein	DANRE|ZFIN=ZDB-GENE-010130-1|UniProtKB=Q9DEG7	CtBP1 protein	IDA	10375506	PubMed	PTHR10996:SF128	C-TERMINAL-BINDING PROTEIN 1
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	IPI	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	MOUSE|MGI=MGI=99578|UniProtKB=Q61616	D(1A) dopamine receptor	ISS	11861492	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00057	Wnt signaling pathway	P01439	C-terminal Binding Protein	BOVIN|Ensembl=ENSBTAG00000008480|UniProtKB=F1MYP4	Uncharacterized protein	ISS	10375506	PubMed	PTHR10996:SF128	C-TERMINAL-BINDING PROTEIN 1
P00010	B cell activation	P00397	IKK	HUMAN|HGNC=5960|UniProtKB=O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	IGI	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	AQUAE|EnsemblGenome=aq_078|UniProtKB=O66490	Adenylate kinase	ISS			PTHR23359:SF22	GTP:AMP PHOSPHOTRANSFERASE, MITOCHONDRIAL
P00057	Wnt signaling pathway	P01444	Wnt	MACMU|Ensembl=ENSMMUG00000021725|UniProtKB=F7E738	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	HUMAN|HGNC=2345|UniProtKB=P16220	Cyclic AMP-responsive element-binding protein 1	RCA			PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	MONDO|Ensembl=ENSMODG00000010516|UniProtKB=F7DR73	Protein-serine/threonine kinase	RCA			PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P00012	Cadherin signaling pathway	P00470	F-actin	TRIAD|EnsemblGenome=TriadG56111|UniProtKB=B3RX77	Non-muscle actin 6.2	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	STRPU|EnsemblGenome=SPU_000062|UniProtKB=W4X9L8	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01093	AChE	CAEBR|Gene=CBG14965|UniProtKB=A8XL40	Carboxylic ester hydrolase	ISS	87080761	PubMed	PTHR43918:SF6	CARBOXYLIC ESTER HYDROLASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	CANLF|Ensembl=ENSCAFG00000002613|UniProtKB=E2QT50	Uncharacterized protein	ISS			PTHR10024:SF282	SYNAPTOTAGMIN-5
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IGI	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00023	General transcription regulation	P00658	TBP-associated factors	RAT|RGD=727861|UniProtKB=Q5BKE0	Transcription initiation factor TFIID subunit 9	ISS			PTHR12595:SF8	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 9
P00018	EGF receptor signaling pathway	G01511	SPRY	RAT|RGD=1311472|UniProtKB=Q5HZA2	Protein Spry2	IGI	12225946	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	MOUSE|MGI=MGI=1096331|UniProtKB=O35544	Excitatory amino acid transporter 4	IC	94365697	PubMed	PTHR11958:SF67	EXCITATORY AMINO ACID TRANSPORTER 4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00020	FAS signaling pathway	P00615	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	IC	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00049	Parkinson disease	P01211	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	IDA	1169551	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00373	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01319	PAK	CHICK|Ensembl=ENSGALG00000008058|UniProtKB=F1N8W8	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00049	Parkinson disease	P01219	SAPK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	NAS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00007	Axon guidance mediated by semaphorins	P00341	Rho	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	ISS	11360179	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00047	PDGF signaling pathway	P01160	IP3 receptor	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05918	p38 MAPK pathway	P06021	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	10891487	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00474	Wnt	CIOIN|Ensembl=ENSCING00000000407|UniProtKB=Q9U6V0	Protein Wnt	IDA	8717036	PubMed	PTHR12027:SF77	PROTEIN WNT-5
P00006	Apoptosis signaling pathway	P00260	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00630	RKIP	ORYSJ|EnsemblGenome=OS06G0157700|UniProtKB=Q93WI9	Protein HEADING DATE 3A	NAS			PTHR11362:SF9	PROTEIN FLOWERING LOCUS T-RELATED
P00018	EGF receptor signaling pathway	P00552	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00007	Axon guidance mediated by semaphorins	P00340	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	MOUSE|MGI=MGI=94925|UniProtKB=P30728	D(3) dopamine receptor	RCA	11861492	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00006	Apoptosis signaling pathway	P00302	ATF	HUMAN|HGNC=784|UniProtKB=P15336	Cyclic AMP-dependent transcription factor ATF-2	ISS	7875593	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	IC	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00981	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT2G18170|UniProtKB=Q39027	Mitogen-activated protein kinase 7	ISS	8282107	PubMed	PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	CHICK|Ensembl=ENSGALG00000009844|UniProtKB=P68034	Actin, alpha cardiac muscle 1	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000003364|UniProtKB=F6ZPQ4	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05916	Opioid prodynorphin pathway	P06002	G-protein	ORNAN|Ensembl=ENSOANG00000003489|UniProtKB=F7FSE3	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00139	E-cadherin transmembrane fragment	PANTR|Ensembl=ENSPTRG00000008270|UniProtKB=H2QBE5	Uncharacterized protein	ISS	12834808	PubMed	PTHR24027:SF319	CADHERIN-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00005	Angiogenesis	P00186	FGFR-1	RAT|RGD=620713|UniProtKB=Q04589	Fibroblast growth factor receptor 1	ISS	9763444	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00057	Wnt signaling pathway	P01457	GBeta	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	MACMU|Ensembl=ENSMMUG00000018375|UniProtKB=F7H1D5	Neurogenic locus notch homolog protein 2 isoform 1 preproprotein	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00645	Rac	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00008	Axon guidance mediated by Slit/Robo	P00344	Netrin	RAT|RGD=619811|UniProtKB=G3V6X3	Netrin 2-like (Chicken)	ISS			PTHR10574:SF292	NETRIN-3
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P05913	Enkephalin release	P05977	G-Protein (s)	ANOGA|EnsemblGenome=AGAP006521|UniProtKB=Q7Q5C3	AGAP006521-PA	IC			PTHR10218:SF229	GUANINE NUCLEOTIDE-BINDING PROTEIN G F  SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P02774	Salvage pyrimidine deoxyribonucleotides	P03145	Uracil phosphorylase	MYCTU|EnsemblGenome=Rv3314c|UniProtKB=P9WFS1	Thymidine phosphorylase	ISS			PTHR10515:SF0	THYMIDINE PHOSPHORYLASE
P00030	Hypoxia response via HIF activation	P00825	Thioredoxin	IXOSC|EnsemblGenome=ISCW020805|UniProtKB=B7PXT0	Thioredoxin	ISS			PTHR10438:SF215	THIOREDOXIN DOMAIN-CONTAINING PROTEIN, MITOCHONDRIAL
P00021	FGF signaling pathway	P00642	MEK1-2	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00009	Axon guidance mediated by netrin	P00366	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00049	Parkinson disease	P01211	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00054	Toll receptor signaling pathway	P01369	MKK1	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00047	PDGF signaling pathway	P01159	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00019	Endothelin signaling pathway	P00570	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12701063	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00010	B cell activation	P00371	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00910	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8617307	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00029	Huntington disease	P00779	TBP	XENTR|Xenbase=XB-GENE-488470|UniProtKB=Q28GG8	TATA-box-binding protein	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P02754	Methylcitrate cycle	P03028	Aconitase	RAT|RGD=621539|UniProtKB=Q62751	Iron-responsive element-binding protein 2	ISS			PTHR11670:SF31	IRON-RESPONSIVE ELEMENT-BINDING PROTEIN 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P02738	De novo purine biosynthesis	P02891	GDP kinase	METJA|EnsemblGenome=MJ_1265|UniProtKB=Q58661	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00020	FAS signaling pathway	P00599	Caspase3	RAT|RGD=2275|UniProtKB=P55213	Caspase-3	IGI	9323209	PubMed	PTHR10454:SF198	CASPASE-3
P00030	Hypoxia response via HIF activation	P00819	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	TAS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00645	Rac	CHICK|Ensembl=ENSGALG00000002859|UniProtKB=F6UBD2	Uncharacterized protein	ISS	15470041	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04431	5HT transporter	PANTR|Ensembl=ENSPTRG00000008958|UniProtKB=H2QCL1	Transporter	ISS	7681602	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02743	Formyltetrahydroformate biosynthesis	P02952	Methylene tetrahydrofolate dehydrogenase	CAEEL|WormBase=WBGene00000929|UniProtKB=Q21285	Dauer or Aging adult Overexpression	ISS			PTHR10025:SF57	DAUER OR AGING ADULT OVEREXPRESSION
P00019	Endothelin signaling pathway	P00591	PLCbeta	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02785	Valine biosynthesis	P03215	Branched chain amino acid aminotransferase	MOUSE|MGI=MGI=104861|UniProtKB=P24288	Branched-chain-amino-acid aminotransferase, cytosolic	ISS			PTHR11825:SF51	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, CYTOSOLIC
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00018	EGF receptor signaling pathway	P00552	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00023	General transcription regulation	P00660	RNA Polymerase II	ANOGA|EnsemblGenome=AGAP012397|UniProtKB=Q7Q0D5	AGAP012397-PA	ISS	606023	OMIM	PTHR10917:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04393	Ras Pathway	P04542	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01230	Src kinase	RAT|RGD=2641|UniProtKB=Q62844	Tyrosine-protein kinase Fyn	IDA	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00005	Angiogenesis	P00243	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	MACMU|Ensembl=ENSMMUG00000010574|UniProtKB=A5A6H2	C-fos	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	XENTR|Xenbase=XB-GENE-483904|UniProtKB=F7ESG8	Receptor protein serine/threonine kinase (Fragment)	ISS	10683140	PubMed	PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P00047	PDGF signaling pathway	P01167	Ets	HUMAN|HGNC=18562|UniProtKB=Q99581	Protein FEV	ISS	15298723	PubMed	PTHR11849:SF203	PROTEIN FEV
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	14744463	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00005	Angiogenesis	P00223	Akt	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS			PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01455	Smad4	BOVIN|Gene=SMAD4|UniProtKB=Q1HE26	Mothers against decapentaplegic homolog 4	ISS	9395284	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P00006	Apoptosis signaling pathway	P00274	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	ARATH|TAIR=AT4G34240|UniProtKB=Q8W033	Aldehyde dehydrogenase family 3 member I1, chloroplastic	IC			PTHR43570:SF10	ALDEHYDE DEHYDROGENASE FAMILY 3 MEMBER I1, CHLOROPLASTIC
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=12778|UniProtKB=O14904	Protein Wnt-9a	IDA	11266476	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P00009	Axon guidance mediated by netrin	P00366	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12176041	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00055	Transcription regulation by bZIP transcription factor	P01390	TFIIA complex	BOVIN|Ensembl=ENSBTAG00000010298|UniProtKB=Q32L01	Transcription initiation factor IIA subunit 2	ISS	95241493	PubMed	PTHR10966:SF0	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2
P04393	Ras Pathway	P04542	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00012	Cadherin signaling pathway	P00475	Frizzled	RAT|RGD=71017|UniProtKB=Q9QZH0	Frizzled-4	IDA	11212302	PubMed	PTHR11309:SF23	FRIZZLED-4
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	HUMAN|HGNC=20773|UniProtKB=Q3ZCM7	Tubulin beta-8 chain	ISS	9454836	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00638	PLCgamma	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CANLF|Ensembl=ENSCAFG00000009967|UniProtKB=F1PGZ2	Muscarinic acetylcholine receptor	ISS	11166329	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=2136737|UniProtKB=Q91XZ7	Protein Pcdhb3	IDA	8120095	PubMed	PTHR24028:SF118	PROTOCADHERIN BETA-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01063	CAT	CAEEL|WormBase=WBGene00007175|UniProtKB=Q17499	Uncharacterized protein	ISS			PTHR22589:SF103	CARNITINE O-ACETYL-TRANSFERASE, ISOFORM A
P00057	Wnt signaling pathway	P01451	Galpha	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DICDI|dictyBase=DDB_G0279413|UniProtKB=P05987	cAMP-dependent protein kinase regulatory subunit	IC	176910	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	14744463	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00034	Integrin signalling pathway	P00936	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IPI	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05941	GRK3	CHICK|Ensembl=ENSGALG00000005518|UniProtKB=F1NTL1	Protein-serine/threonine kinase	ISS	10852916	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	RCA	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00015	Circadian clock system	G01503	per	MOUSE|MGI=MGI=1098283|UniProtKB=O35973	Period circadian protein homolog 1	IDA	12782655	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P00047	PDGF signaling pathway	P01142	p90RSK	CHICK|Ensembl=ENSGALG00000005198|UniProtKB=F1P4J0	Ribosomal protein S6 kinase	ISS	11861821	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	RAT|RGD=2156|UniProtKB=P29066	Beta-arrestin-1	IDA	4757780	gi	PTHR11792:SF22	BETA-ARRESTIN-1
P04393	Ras Pathway	P04567	PI3K	XENTR|Xenbase=XB-GENE-6085226|UniProtKB=F6ZM84	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00050	Plasminogen activating cascade	P01250	MMP-13	MOUSE|MGI=MGI=1340026|UniProtKB=P33435	Collagenase 3	ISS	12834808	PubMed	PTHR10201:SF165	COLLAGENASE 3
P00047	PDGF signaling pathway	P01159	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00007	Axon guidance mediated by semaphorins	P00340	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00025	Hedgehog signaling pathway	P00686	Fused	HUMAN|HGNC=17209|UniProtKB=Q9NRP7	Serine/threonine-protein kinase 36	ISS			PTHR22983:SF6	SERINE/THREONINE-PROTEIN KINASE 36
P00005	Angiogenesis	P00231	HSP27	CANLF|Ensembl=ENSCAFG00000023925|UniProtKB=E2RTA9	Uncharacterized protein	ISS			PTHR11527:SF163	HEAT SHOCK PROTEIN BETA-2
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00021	FGF signaling pathway	P00638	PLCgamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IGI	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00057	Wnt signaling pathway	P01451	Galpha	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	IDA	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	BOVIN|Ensembl=ENSBTAG00000000469|UniProtKB=P67774	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	BOVIN|Gene=GTF2B|UniProtKB=Q2KIN8	Transcription initiation factor IIB	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P00057	Wnt signaling pathway	P01444	Wnt	CANLF|Ensembl=ENSCAFG00000009672|UniProtKB=E2RDT2	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00010	B cell activation	P00367	NFAT	RAT|RGD=1307690|UniProtKB=D4A0I8	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (Predicted), isoform CRA_b	ISS	9133421	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	HUMAN|HGNC=1401|UniProtKB=Q02641	Voltage-dependent L-type calcium channel subunit beta-1	ISS	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00049	Parkinson disease	P01219	SAPK	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	NAS	11707292	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00006	Apoptosis signaling pathway	P00270	Bcl-2	PANTR|Ensembl=ENSPTRG00000010079|UniProtKB=H2QEM8	B-cell CLL/lymphoma 2	ISS	2250705	PubMed	PTHR11256:SF11	APOPTOSIS REGULATOR BCL-2
P00029	Huntington disease	P00786	ARF	BOVIN|Ensembl=ENSBTAG00000045980|UniProtKB=G3N3N1	Uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00046	Oxidative stress response	P01129	JNK1/2	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00023	General transcription regulation	P00666	TFIIE	ANOGA|EnsemblGenome=AGAP006355|UniProtKB=Q5TR07	AGAP006355-PA	ISS			PTHR13097:SF7	NOVEL PROTEIN SIMILAR TO VERTEBRATE GENERAL TRANSCRIPTION FACTOR IIE POLYPEPTIDE 1 ALPHA 56KDA  GTF2E1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000006342|UniProtKB=H2Q8A8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00025	Hedgehog signaling pathway	P00692	GSK3	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00011	Blood coagulation	P00445	FXa	PANTR|Ensembl=ENSPTRG00000006050|UniProtKB=H2Q7T9	Coagulation factor X	ISS	4503625	gi	PTHR44064:SF3	COAGULATION FACTOR X
P00034	Integrin signalling pathway	P00924	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00011	Blood coagulation	P00440	ATIII	HUMAN|HGNC=775|UniProtKB=P01008	Antithrombin-III	ISS	576554	gi	PTHR11461:SF53	ANTITHROMBIN-III
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	MOUSE|MGI=MGI=2447811|UniProtKB=A6ZI46	Fructose-bisphosphate aldolase	ISS	4812352	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00055	Transcription regulation by bZIP transcription factor	P01398	TFIIEalpha	MOUSE|MGI=MGI=1921447|UniProtKB=Q9D0D5	General transcription factor IIE subunit 1	ISS	189962	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00048	PI3 kinase pathway	P01192	p110	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P04398	p53 pathway feedback loops 2	P04658	PTEN	DROME|FlyBase=FBgn0026379|UniProtKB=Q7KMQ6	IP16020p	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00017	DNA replication	P00527	Histones	DAPPU|EnsemblGenome=DAPPUDRAFT_231307|UniProtKB=E9H1C5	Histone H3	ISS	20448842	PubMed	PTHR11426:SF179	HISTONE H3.3
P00006	Apoptosis signaling pathway	P00311	GCKR	CHICK|Ensembl=ENSGALG00000013227|UniProtKB=F1NLQ4	Mitogen-activated protein kinase kinase kinase kinase	ISS			PTHR24361:SF205	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 3
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00006	Apoptosis signaling pathway	P00307	ELF2alpha	METJA|EnsemblGenome=MJ_0117|UniProtKB=Q57581	Translation initiation factor 2 subunit alpha	ISS			PTHR10602:SF0	EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	TAS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00019	Endothelin signaling pathway	P00572	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02776	Serine glycine biosynthesis	P03160	Phosphoglycerate dehydrogenase	MOUSE|MGI=MGI=1355330|UniProtKB=Q61753	D-3-phosphoglycerate dehydrogenase	ISS			PTHR42938:SF5	D-3-PHOSPHOGLYCERATE DEHYDROGENASE
P00005	Angiogenesis	P00200	Dsh	RAT|RGD=1309725|UniProtKB=D3ZB71	Protein Dvl2	ISS	10409711	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P00034	Integrin signalling pathway	P00925	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MOUSE|MGI=MGI=98728|UniProtKB=Q64729	TGF-beta receptor type-1	TAS	9395284	PubMed	PTHR23255:SF61	TGF-BETA RECEPTOR TYPE-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01154	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P04397	p53 pathway by glucose deprivation	P04641	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01159	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	RAT|RGD=3380|UniProtKB=P63331	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000010591|UniProtKB=H2R6B7	Uncharacterized protein	ISS	10644715	PubMed	PTHR24356:SF246	SERINE/THREONINE-PROTEIN KINASE N1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IDA	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00562	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00012	Cadherin signaling pathway	P00470	F-actin	DROME|FlyBase=FBgn0000042|UniProtKB=P10987	Actin-5C	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00010	B cell activation	P00392	I kappa B	RAT|RGD=1303310|UniProtKB=Q8R2H1	NF-kappa-B inhibitor-like protein 1	ISS	10811867	PubMed	PTHR15263:SF1	NF-KAPPA-B INHIBITOR-LIKE PROTEIN 1
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	PANTR|Ensembl=ENSPTRG00000013022|UniProtKB=H2QJL0	Uncharacterized protein	ISS	12181435	PubMed	PTHR24247:SF31	5-HYDROXYTRYPTAMINE RECEPTOR 2B
P00034	Integrin signalling pathway	P00922	Collagen	MACMU|Ensembl=ENSMMUG00000005716|UniProtKB=F6TX32	Uncharacterized protein	ISS	10778855	PubMed	PTHR44988:SF1	COLLAGEN ALPHA-1 XIII  CHAIN
P04393	Ras Pathway	P04575	TAK	MOUSE|MGI=MGI=2446584|UniProtKB=P58500	MAP3K7 C-terminal-like protein	ISS	10683140	PubMed	PTHR26392:SF77	EXTRACELLULAR TYROSINE-PROTEIN KINASE PKDCC
P04393	Ras Pathway	P04546	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	RAT|RGD=2061|UniProtKB=P26255	Beta-3 adrenergic receptor	IDA	12063255	PubMed	PTHR24248:SF3	BETA-3 ADRENERGIC RECEPTOR
P00034	Integrin signalling pathway	P00944	Actin	PANTR|Ensembl=ENSPTRG00000018890|UniProtKB=Q5R1X3	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00037	Ionotropic glutamate receptor pathway	P01026	KA	HUMAN|HGNC=4579|UniProtKB=P39086	Glutamate receptor ionotropic, kainate 1	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MONDO|Ensembl=ENSMODG00000000771|UniProtKB=F6SSS3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02738	De novo purine biosynthesis	P02902	ADP reductase	BOVIN|Ensembl=ENSBTAG00000013111|UniProtKB=F1MSF1	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00021	FGF signaling pathway	P00633	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P02748	Isoleucine biosynthesis	P02997	Acetolactate synthase	STRCO|Gene=CAB66308|UniProtKB=Q9RDF9	Putative acetolactate synthase	ISS			PTHR18968:SF13	ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL
P00035	Interferon-gamma signaling pathway	P00959	IFNGR1	MOUSE|MGI=MGI=107655|UniProtKB=P15261	Interferon gamma receptor 1	TAS	14525967	PubMed	PTHR20859:SF5	INTERFERON GAMMA RECEPTOR 1
P00034	Integrin signalling pathway	P00907	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00056	VEGF signaling pathway	P01413	PI3K	DROME|FlyBase=FBgn0015278|UniProtKB=Q7K3H0	LD28067p	ISS	96278830	PubMed	PTHR10048:SF64	LD28067P
P00037	Ionotropic glutamate receptor pathway	P01023	CaMKII	CHICK|Ensembl=ENSGALG00000005088|UniProtKB=E1BZ86	Uncharacterized protein	ISS	12888804	PubMed	PTHR43940:SF7	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT GAMMA
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00736	CalDAG-GEF	MOUSE|MGI=MGI=2386851|UniProtKB=Q8BTM9	RAS guanyl-releasing protein 4	IDA	10835426	PubMed	PTHR23113:SF157	RAS GUANYL-RELEASING PROTEIN 4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IDA			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IC	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CAEEL|WormBase=WBGene00004036|UniProtKB=G5EFI8	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00059	p53 pathway	P04609	PI3K	DROME|FlyBase=FBgn0015278|UniProtKB=Q7K3H0	LD28067p	ISS	7937853	PubMed	PTHR10048:SF64	LD28067P
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00012	Cadherin signaling pathway	P00470	F-actin	DICDI|dictyBase=DDB_G0289489|UniProtKB=P07828	Actin-18	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00059	p53 pathway	G04689	Cyclin G	MOUSE|MGI=MGI=102890|UniProtKB=P51945	Cyclin-G1	ISS	7957050	PubMed	PTHR10177:SF59	CYCLIN-G1
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IGI	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00624	14-3-3	MOUSE|MGI=MGI=109194|UniProtKB=P68510	14-3-3 protein eta	IGI	10407019	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	TAS	98382502	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01188	Gbetagamma	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00068	amine translocator	PANTR|Ensembl=ENSPTRG00000011288|UniProtKB=H2QGU3	Transporter	ISS	12719981	PubMed	PTHR11616:SF113	ORPHAN SODIUM- AND CHLORIDE-DEPENDENT NEUROTRANSMITTER TRANSPORTER NTT5
P05731	GABA-B receptor II signaling	P05752	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CAEBR|Gene=CBG23090|UniProtKB=A8Y4R0	Protein CBG23090	ISS	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Ensembl=ENSBTAG00000014674|UniProtKB=P41985	Muscarinic acetylcholine receptor M2	ISS	11166329	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	MACMU|Ensembl=ENSMMUG00000028962|UniProtKB=F7EWG5	Uncharacterized protein	ISS			PTHR23050:SF322	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00049	Parkinson disease	P01227	20S proteasome	CANLF|Ensembl=ENSCAFG00000018134|UniProtKB=E2RF52	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF47	PROTEASOME SUBUNIT ALPHA TYPE-7-LIKE
P00005	Angiogenesis	P00219	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g210933|UniProtKB=A7SEA7	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	HUMAN|HGNC=6091|UniProtKB=P06213	Insulin receptor	ISS	11182407	gi	PTHR24416:SF402	INSULIN RECEPTOR
P06664	Gonadotropin-releasing hormone receptor pathway	P06779	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	RCA	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00243	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01150	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00645	Rac	ENTHI|EnsemblGenome=EHI_129750|UniProtKB=C4M5Q7	Rho family GTPase	IGI	4757952	gi	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00021	FGF signaling pathway	P00641	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00056	VEGF signaling pathway	P01421	Rac	RAT|RGD=1303143|UniProtKB=Q6AYD8	Protein Arhgap8	ISS			PTHR23176:SF3	PROTEIN PRR5-ARHGAP8-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	2837282	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000006289|UniProtKB=H2Q875	Uncharacterized protein	ISS	12562507	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	DROME|FlyBase=FBgn0004611|UniProtKB=P25455	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P02746	Heme biosynthesis	P02980	Coproporphyrinogen Oxidase (oxygen dependent)	HUMAN|HGNC=2321|UniProtKB=P36551	Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial	ISS			PTHR10755:SF0	OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	DROME|FlyBase=FBgn0004647|UniProtKB=P07207	Neurogenic locus Notch protein	IDA	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P04393	Ras Pathway	P04555	PDK	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	IDA	11256888	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P02771	Pyrimidine Metabolism	P03128	Dihydrouracil Dehydrogenase	HUMAN|HGNC=3012|UniProtKB=Q12882	Dihydropyrimidine dehydrogenase [NADP(+)]	TAS	1512248	PubMed	PTHR43073:SF2	DIHYDROPYRIMIDINE DEHYDROGENASE  NADP +
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	DANRE|ZFIN=ZDB-GENE-000330-9|UniProtKB=Q90ZE4	Presenilin-2	IDA	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00056	VEGF signaling pathway	P01409	cPLA2	MACMU|Ensembl=ENSMMUG00000021423|UniProtKB=F7EEZ1	Phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P02783	Tryptophan biosynthesis	P03207	Tryptophan synthase A	METAC|EnsemblGenome=MA_2990|UniProtKB=Q8TLP4	Tryptophan synthase alpha chain	ISS			PTHR43406:SF1	TRYPTOPHAN SYNTHASE ALPHA CHAIN
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	DROME|FlyBase=FBgn0039580|UniProtKB=Q9VAW3	GH12731p	ISS			PTHR10937:SF0	GH12731P-RELATED
P00057	Wnt signaling pathway	P01465	Ggamma	ANOGA|EnsemblGenome=AGAP009953|UniProtKB=Q7PMD1	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR15936:SF2	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-13
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	ANOGA|EnsemblGenome=AGAP001394|UniProtKB=F5HMS4	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IGI	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	RAT|RGD=70487|UniProtKB=Q9WU82	Catenin beta-1	TAS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00019	Endothelin signaling pathway	P00591	PLCbeta	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00839	SHIP	MACMU|Ensembl=ENSMMUG00000010451|UniProtKB=F7CRA7	Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2	ISS	12145149	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P02762	Pentose phosphate pathway	P03081	Transaldolase	MOUSE|MGI=MGI=1274789|UniProtKB=Q93092	Transaldolase	ISS	8300619	PubMed	PTHR10683:SF18	TRANSALDOLASE
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IC	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	MOUSE|MGI=MGI=1888711|UniProtKB=Q9Z126	Platelet factor 4	IDA	10453028	PubMed	PTHR10179:SF43	PLATELET FACTOR 4
P00021	FGF signaling pathway	P00629	PP2A	ORNAN|Ensembl=ENSOANG00000009097|UniProtKB=F7G755	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00056	VEGF signaling pathway	P01402	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	RCA			PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00762	HAP1	RAT|RGD=68327|UniProtKB=P54256	Huntingtin-associated protein 1	IPI	7477378	PubMed	PTHR15751:SF14	HUNTINGTIN-ASSOCIATED PROTEIN 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00034	Integrin signalling pathway	P00907	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00920	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00561	STAT	RAT|RGD=3772|UniProtKB=P52631	Signal transducer and activator of transcription 3	IGI	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00547	PP2A	TRIAD|EnsemblGenome=TriadG63380|UniProtKB=B3S653	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01408	Akt/PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00034	Integrin signalling pathway	P00951	Jnk	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02738	De novo purine biosynthesis	P02902	ADP reductase	MONDO|Ensembl=ENSMODG00000005993|UniProtKB=F6SL91	Uncharacterized protein	ISS			PTHR23409:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 B
P00037	Ionotropic glutamate receptor pathway	P01026	KA	ORNAN|Ensembl=ENSOANG00000002061|UniProtKB=F7ANC6	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00049	Parkinson disease	P01211	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04548	ATF2	MOUSE|MGI=MGI=109349|UniProtKB=P16951	Cyclic AMP-dependent transcription factor ATF-2	IDA	11390664	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00010	B cell activation	P00384	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IDA	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00010	B cell activation	P00398	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05915	Opioid proenkephalin pathway	P05985	Mu or Delta receptor	PANTR|Ensembl=ENSPTRG00000000440|UniProtKB=H2PYH8	Uncharacterized protein	ISS	11259498	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	CHICK|Ensembl=ENSGALG00000009320|UniProtKB=Q4JIM4	Presenilin-1	TAS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P02770	Pyridoxal phosphate salvage pathway	P03123	Pyridoxine-5-phosphate oxidase	SYNY3|EnsemblGenome=BAA18303|UniProtKB=P74211	Pyridoxine/pyridoxamine 5'-phosphate oxidase	ISS	8590279	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00005	Angiogenesis	P00203	Erk	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00767	Pro-caspase 8	CHICK|Ensembl=ENSGALG00000008355|UniProtKB=F1NXP6	Uncharacterized protein	IDA	8681376	PubMed	PTHR10454:SF162	CASPASE-8
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00034	Integrin signalling pathway	P00951	Jnk	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00005	Angiogenesis	P00213	FGF	BOVIN|Gene=FGF2|UniProtKB=P03969	Fibroblast growth factor 2	ISS			PTHR11486:SF83	FIBROBLAST GROWTH FACTOR 2
P00029	Huntington disease	P00780	Microtubule	DANRE|ZFIN=ZDB-GENE-031110-4|UniProtKB=Q6NW90	Tubulin, beta 5	ISS	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00006	Apoptosis signaling pathway	P00260	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01284	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	TAS	97102676	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MONDO|Ensembl=ENSMODG00000013970|UniProtKB=F6R6X5	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00059	p53 pathway	P04630	PP2A	BOVIN|Ensembl=ENSBTAG00000009245|UniProtKB=Q0P594	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P06664	Gonadotropin-releasing hormone receptor pathway	P06832	c-Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	RCA	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00547	PP2A	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g195622|UniProtKB=A7T2Q5	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9063|UniProtKB=Q15111	Inactive phospholipase C-like protein 1	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P00018	EGF receptor signaling pathway	P00555	MKK4,7	HUMAN|HGNC=6844|UniProtKB=P45985	Dual specificity mitogen-activated protein kinase kinase 4	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00018	EGF receptor signaling pathway	P00548	RKIP	RAT|RGD=62017|UniProtKB=P31044	Phosphatidylethanolamine-binding protein 1	IGI	7637590	PubMed	PTHR11362:SF10	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05731	GABA-B receptor II signaling	P05752	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CANLF|Ensembl=ENSCAFG00000009967|UniProtKB=F1PGZ2	Muscarinic acetylcholine receptor	ISS	12915051	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	MOUSE|MGI=MGI=88397|UniProtKB=Q9ERZ4	Muscarinic acetylcholine receptor M2	ISS	8100450	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00049	Parkinson disease	P01208	Hsp70	ORYSJ|EnsemblGenome=OS02G0115900|UniProtKB=Q6Z7B0	Dnak-type molecular chaperone Bip	IDA	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IC	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00023	General transcription regulation	P00661	TTF2	PANTR|Ensembl=ENSPTRG00000021496|UniProtKB=H2QY30	Uncharacterized protein	ISS			PTHR10641:SF939	TRANSCRIPTION TERMINATION FACTOR 1
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00965	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00017	DNA replication	P00533	Pol delta	BOVIN|Ensembl=ENSBTAG00000012241|UniProtKB=P49004	DNA polymerase delta subunit 2	ISS	96079106	PubMed	PTHR10416:SF0	DNA POLYMERASE DELTA SUBUNIT 2
P00029	Huntington disease	P00807	Actin	MOUSE|MGI=MGI=87902|UniProtKB=P68134	Actin, alpha skeletal muscle	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P02762	Pentose phosphate pathway	P03071	Ribulose 5-P Isomerase	ECOLI|EcoGene=EG11443|UniProtKB=P0A7Z0	Ribose-5-phosphate isomerase A	RCA			PTHR11934:SF0	RIBOSE-5-PHOSPHATE ISOMERASE
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	CANLF|Ensembl=ENSCAFG00000010476|UniProtKB=F1PS94	Uncharacterized protein	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	PANTR|Ensembl=ENSPTRG00000007514|UniProtKB=H2R439	Uncharacterized protein	ISS			PTHR42884:SF8	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	TAS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00018	EGF receptor signaling pathway	P00547	PP2A	DROME|FlyBase=FBgn0027492|UniProtKB=Q9VB23	BcDNA.LD34343	ISS			PTHR10257:SF29	BCDNA.LD34343
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	TAS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	SCHPO|PomBase=SPAC6G9.11|UniProtKB=Q92356	Synaptobrevin homolog 1	ISS	14997396	PubMed	PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00034	Integrin signalling pathway	P00925	MEK	CHICK|Ensembl=ENSGALG00000001001|UniProtKB=F1P3T1	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00021	FGF signaling pathway	P00633	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=2652894|UniProtKB=Q80Y86	Mitogen-activated protein kinase 15	ISS	10514528	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=12788|UniProtKB=Q9H1J5	Protein Wnt-8a	IDA	11266476	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	YEAST|SGD=S000001324|UniProtKB=P40518	Actin-related protein 2/3 complex subunit 5	ISS			PTHR12644:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00047	PDGF signaling pathway	P01168	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00647	SHP2	MACMU|Ensembl=ENSMMUG00000013253|UniProtKB=F6ZJD8	Tyrosine-protein phosphatase non-receptor type	ISS	14525967	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT2G18170|UniProtKB=Q39027	Mitogen-activated protein kinase 7	IDA	8282107	PubMed	PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IC	3755548	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P02721	ATP synthesis	P02796	F1 gamma	HUMAN|HGNC=833|UniProtKB=P36542	ATP synthase subunit gamma, mitochondrial	ISS	9525963	PubMed	PTHR11693:SF22	ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	HUMAN|HGNC=4600|UniProtKB=O00222	Metabotropic glutamate receptor 8	IC	12488551	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00034	Integrin signalling pathway	P00944	Actin	RAT|RGD=1309504|UniProtKB=D3ZRN3	Protein Actbl2	ISS	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95810|UniProtKB=Q9Z2W9	Glutamate receptor 3	ISS	10331083	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00012	Cadherin signaling pathway	P00470	F-actin	ANOGA|EnsemblGenome=AGAP000651|UniProtKB=P84185	Actin-5C	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00629	PP2A	DICPU|Gene=DICPUDRAFT_76474|UniProtKB=F0ZDQ6	Serine/threonine-protein phosphatase	ISS			PTHR11668:SF22	SERINE/THREONINE-PROTEIN PHOSPHATASE 4 CATALYTIC SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	MOUSE|MGI=MGI=1339975|UniProtKB=O88643	Serine/threonine-protein kinase PAK 1	ISS	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00029	Huntington disease	P00774	Dynein complex	HUMAN|HGNC=15476|UniProtKB=P63167	Dynein light chain 1, cytoplasmic	IPI	9454836	PubMed	PTHR11886:SF52	DYNEIN LIGHT CHAIN 1, CYTOPLASMIC
P00018	EGF receptor signaling pathway	P00552	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00006	Apoptosis signaling pathway	P00260	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IDA	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IC	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00059	p53 pathway	P04613	B99	PANTR|Ensembl=ENSPTRG00000014509|UniProtKB=H2QLW6	G-2 and S-phase expressed 1	ISS	12750368	PubMed	PTHR21584:SF10	G2 AND S PHASE-EXPRESSED PROTEIN 1
P00054	Toll receptor signaling pathway	P01339	TLR4	MACMU|Ensembl=ENSMMUG00000009112|UniProtKB=F7HU26	Toll-like receptor 4	ISS			PTHR44568:SF1	TOLL-LIKE RECEPTOR 4
P00007	Axon guidance mediated by semaphorins	P00340	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	CAEEL|WormBase=WBGene00001679|UniProtKB=P17343	Guanine nucleotide-binding protein subunit beta-1	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IC	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02783	Tryptophan biosynthesis	P03208	Tryptophan synthase B	PSEAE|EnsemblGenome=PA0036|UniProtKB=P07345	Tryptophan synthase beta chain	ISS			PTHR42882:SF1	TRYPTOPHAN SYNTHASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06787	SMAD1/5/8	MOUSE|MGI=MGI=109452|UniProtKB=P70340	Mothers against decapentaplegic homolog 1	RCA	9395284	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P00005	Angiogenesis	P00206	Wnt	RAT|RGD=69079|UniProtKB=M0R9D3	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00050	Plasminogen activating cascade	P01250	MMP-13	BOVIN|Gene=MMP13|UniProtKB=O77656	Collagenase 3	ISS	8207000	PubMed	PTHR10201:SF165	COLLAGENASE 3
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IPI	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02772	Pyruvate metabolism	P03136	Malic enzyme	MACMU|Ensembl=ENSMMUG00000012592|UniProtKB=F7FDW2	Malic enzyme	ISS	9954437	gi	PTHR23406:SF17	NADP-DEPENDENT MALIC ENZYME
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00780	Microtubule	TAKRU|Ensembl=ENSTRUG00000005446|UniProtKB=H2SKZ5	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00034	Integrin signalling pathway	P00927	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	RCA			PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00561	STAT	BOVIN|Gene=STAT5B|UniProtKB=Q9TUM3	Signal transducer and activator of transcription 5B	ISS	96102059	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00057	Wnt signaling pathway	P01438	PP2A	IXOSC|EnsemblGenome=ISCW014549|UniProtKB=B7QGY5	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=3972|UniProtKB=Q12841	Follistatin-related protein 1	ISS	11266476	PubMed	PTHR10913:SF13	FOLLISTATIN-RELATED PROTEIN 1
P04398	p53 pathway feedback loops 2	P04651	Ras	CHICK|Ensembl=ENSGALG00000006885|UniProtKB=P08642	GTPase HRas	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05731	GABA-B receptor II signaling	P05754	Ggamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	ORNAN|Ensembl=ENSOANG00000011750|UniProtKB=F6TWB9	Nucleoside diphosphate kinase	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P00034	Integrin signalling pathway	P00907	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00775	Rac	DAPPU|EnsemblGenome=DAPPUDRAFT_306746|UniProtKB=E9GYE9	Putative uncharacterized protein	ISS			PTHR24072:SF192	CDC42 HOMOLOG
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	HUMAN|HGNC=4588|UniProtKB=O15399	Glutamate receptor ionotropic, NMDA 2D	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000021808|UniProtKB=Q9MZL3	Voltage-dependent L-type calcium channel subunit beta-3	IC			PTHR11824:SF8	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-3
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	BOVIN|Ensembl=ENSBTAG00000011761|UniProtKB=F1MDE1	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P04393	Ras Pathway	P04570	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00591	PLCbeta	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	IGI	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	TAS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01081	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000019350|UniProtKB=H2R2A6	Calcium channel, voltage-dependent, alpha 2/delta subunit 1	ISS	21601730	PubMed	PTHR10166:SF6	VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	RAT|RGD=71027|UniProtKB=P42264	Glutamate receptor ionotropic, kainate 3	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DICDI|dictyBase=DDB_G0289487|UniProtKB=P07829	Actin-3	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00023	General transcription regulation	P00666	TFIIE	SCHPO|PomBase=SPCC1672.08c|UniProtKB=P79011	Transcription initiation factor IIE subunit beta	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00038	JAK/STAT signaling pathway	P01027	STAT	HUMAN|HGNC=11362|UniProtKB=P42224	Signal transducer and activator of transcription 1-alpha/beta	ISS	14755057	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MONDO|Ensembl=ENSMODG00000001303|UniProtKB=F7BZM9	Uncharacterized protein (Fragment)	ISS	12963527	gi	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00005	Angiogenesis	P00243	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00313	IKK	RAT|RGD=621375|UniProtKB=Q9QY78	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P05915	Opioid proenkephalin pathway	P05992	met-Enkephalin	BOVIN|Ensembl=ENSBTAG00000004924|UniProtKB=P01211	Proenkephalin-A	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	TAS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P02751	Lysine biosynthesis	P03006	Dihydrodipicolinate  reductase	CHLTR|EnsemblGenome=CT_364|UniProtKB=O84369	4-hydroxy-tetrahydrodipicolinate reductase	ISS			PTHR20836:SF0	DIHYDRODIPICOLINATE REDUCTASE-LIKE PROTEIN CRR1, CHLOROPLASTIC
P00057	Wnt signaling pathway	P01444	Wnt	TAKRU|Ensembl=ENSTRUG00000011280|UniProtKB=H2TUW3	Protein Wnt	IDA	8717036	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00029	Huntington disease	P00782	alpha-Adaptin	RAT|RGD=71015|UniProtKB=P18484	AP-2 complex subunit alpha-2	IDA	11532990	PubMed	PTHR22780:SF4	AP-2 COMPLEX SUBUNIT ALPHA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	BRAFL|Gene=BRAFLDRAFT_123893|UniProtKB=C3XQF4	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00914	Filamin	PANTR|Ensembl=ENSPTRG00000015054|UniProtKB=H2R1I3	Filamin B, beta	ISS	9722563	PubMed	PTHR43998:SF3	FILAMIN-B
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	PANTR|Ensembl=ENSPTRG00000008157|UniProtKB=H2QB71	Polymerase (RNA) II (DNA directed) polypeptide C, 33kDa	ISS	2187864	PubMed	PTHR11800:SF2	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00012	Cadherin signaling pathway	P00474	Wnt	PANTR|Ensembl=ENSPTRG00000004893|UniProtKB=H2Q5U4	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04668	p53	BOVIN|Ensembl=ENSBTAG00000015460|UniProtKB=F1MKA9	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00047	PDGF signaling pathway	P01171	PLCgamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CANAL|CGD=CAL0064759|UniProtKB=Q5AKX0	Uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	RAT|RGD=2520|UniProtKB=P61169	D(2) dopamine receptor	ISS	11248120	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00048	PI3 kinase pathway	P01200	SHIP	CANLF|Ensembl=ENSCAFG00000005743|UniProtKB=F1PNY0	Uncharacterized protein	ISS	10610720	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00034	Integrin signalling pathway	P00912	Arp2/3	DANRE|ZFIN=ZDB-GENE-040120-7|UniProtKB=Q7ZWH4	Actin-related protein 2/3 complex subunit 5	IPI	12932731	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000018677|UniProtKB=H2QTV4	Syntaxin 11	ISS	11067767	PubMed	PTHR19957:SF30	SYNTAXIN-11
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01411	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	RAT|RGD=620340|UniProtKB=O35921	Excitatory amino acid transporter 4	ISS	94365697	PubMed	PTHR11958:SF67	EXCITATORY AMINO ACID TRANSPORTER 4
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00059	p53 pathway	P01486	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	MOUSE|MGI=MGI=1298218|UniProtKB=O88572	Low-density lipoprotein receptor-related protein 6	IDA	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00051	TCA cycle	P01271	Fumarase	BOVIN|Ensembl=ENSBTAG00000021688|UniProtKB=Q148D3	Fumarate hydratase	ISS	227665	gi	PTHR11444:SF1	FUMARATE HYDRATASE, MITOCHONDRIAL
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	HUMAN|HGNC=4597|UniProtKB=P41594	Metabotropic glutamate receptor 5	ISS	12351712	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Gene=SSTR2|UniProtKB=P34993	Somatostatin receptor type 2	ISS	12441358	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00859	NFkappaB	HUMAN|HGNC=9955|UniProtKB=Q04206	Transcription factor p65	RCA			PTHR24169:SF1	TRANSCRIPTION FACTOR P65
P00054	Toll receptor signaling pathway	P01368	MKK2	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00005	Angiogenesis	P00203	Erk	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	RAT|RGD=2746|UniProtKB=P31424	Metabotropic glutamate receptor 5	ISS	12488551	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00021	FGF signaling pathway	P00632	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00030	Hypoxia response via HIF activation	P00823	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	7565716	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00021	FGF signaling pathway	P00627	ERK1-2	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P06959	CCKR signaling map	P07228	MAPK1/3	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	RCA	12239223	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00772	FIP-2	MOUSE|MGI=MGI=1918898|UniProtKB=Q8K3K8	Optineurin	TAS			PTHR31553:SF2	OPTINEURIN
P00005	Angiogenesis	P00219	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P02721	ATP synthesis	P02796	F1 gamma	ARATH|TAIR=AT4G04640|UniProtKB=Q01908	ATP synthase gamma chain 1, chloroplastic	ISS	1826905	PubMed	PTHR11693:SF23	MYB-LIKE PROTEIN O
P02759	Pyridoxal-5-phosphate biosynthesis	P03062	1-Deoxyxylulose-5-phosphate synthase	PSEAE|EnsemblGenome=PA4044|UniProtKB=Q9KGU7	1-deoxy-D-xylulose-5-phosphate synthase	ISS			PTHR43322:SF6	1-DEOXY-D-XYLULOSE-5-PHOSPHATE SYNTHASE
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000020887|UniProtKB=F1MP22	Uncharacterized protein	ISS	8386525	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P02763	Peptidoglycan biosynthesis	P03083	UDP-N-acetylmuramoylalanine-D-glutamate ligase	GLOVI|EnsemblGenome=BAC91673|UniProtKB=Q7NEZ5	UDP-N-acetylmuramoylalanine--D-glutamate ligase	ISS			PTHR43692:SF1	UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE
P00029	Huntington disease	P00807	Actin	PHYPA|Gene=PHYPADRAFT_172686|UniProtKB=A9TYG6	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00054	Toll receptor signaling pathway	P01360	IKKbeta	MACMU|Ensembl=ENSMMUG00000008351|UniProtKB=F7HRV5	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00047	PDGF signaling pathway	P01162	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00633	Ras	DICPU|Gene=DICPUDRAFT_57324|UniProtKB=F0ZVH9	Putative uncharacterized protein rasS	ISS	8290260	PubMed	PTHR24070:SF380	RAS-LIKE PROTEIN RASS
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	CAEEL|WormBase=WBGene00008546|UniProtKB=Q19130	Glutamine-Fructose 6-phosphate AminoTransferase homolog	ISS			PTHR10937:SF0	GH12731P-RELATED
P00013	Cell cycle	P00484	Cyclin D	BOVIN|Gene=CCND3|UniProtKB=Q3MHH5	G1/S-specific cyclin-D3	ISS	14576819	PubMed	PTHR10177:SF65	G1/S-SPECIFIC CYCLIN-D3
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	DANRE|ZFIN=ZDB-GENE-000330-9|UniProtKB=Q90ZE4	Presenilin-2	TAS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	RAT|RGD=3562|UniProtKB=P49806	Regulator of G-protein signaling 10	ISS	8756726	PubMed	PTHR10845:SF182	REGULATOR OF G-PROTEIN SIGNALING 10
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04393	Ras Pathway	P04547	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000006232|UniProtKB=H2Q845	Serine/threonine-protein kinase	ISS	12393506	PubMed	PTHR22968:SF9	SERINE/THREONINE-PROTEIN KINASE D1
P00057	Wnt signaling pathway	P01437	TCF	MACMU|Ensembl=ENSMMUG00000020134|UniProtKB=F6U055	Uncharacterized protein	ISS	12356903	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00219	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS			PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00053	T cell activation	P01307	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	IPI	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00018	EGF receptor signaling pathway	P00562	p38	DROME|FlyBase=FBgn0024846|UniProtKB=O61443	Mitogen-activated protein kinase 14B	ISS	11707292	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000001384|UniProtKB=F7GL73	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P02727	Androgen/estrogene/progesterone biosynthesis	P02826	Estradiol 17beta-dehydrogenase	HUMAN|HGNC=5210|UniProtKB=P14061	Estradiol 17-beta-dehydrogenase 1	RCA			PTHR43391:SF15	ESTRADIOL 17-BETA-DEHYDROGENASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00565	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00005	Angiogenesis	P00215	Nck	BOVIN|Ensembl=ENSBTAG00000018427|UniProtKB=Q1LZB2	NCK adaptor protein 1	ISS	12874226	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00048	PI3 kinase pathway	P01182	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	RCA	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00628	JNK1-3	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00307	ELF2alpha	ARATH|TAIR=AT2G40290|UniProtKB=Q9SIZ2	Eukaryotic translation initiation factor 2 subunit 1	ISS			PTHR10602:SF0	EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1
P00046	Oxidative stress response	P01129	JNK1/2	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01159	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00045	Notch signaling pathway	P01104	Serrate	BOVIN|Ensembl=ENSBTAG00000012817|UniProtKB=E1BDN7	Delta-like protein	ISS	12826675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00019	Endothelin signaling pathway	P00574	Big ET1-4	BOVIN|Ensembl=ENSBTAG00000021434|UniProtKB=Q867A9	Endothelin-2	ISS			PTHR13874:SF9	ENDOTHELIN-2
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	PANTR|Ensembl=ENSPTRG00000009085|UniProtKB=H2RDQ2	Uncharacterized protein	ISS	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P05912	Dopamine receptor mediated signaling pathway	P05961	DOPA decarb.	ANOGA|Gene=AgaP_AGAP009091|UniProtKB=Q7PW49	AGAP009091-PA	ISS			PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P05731	GABA-B receptor II signaling	P05760	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	PANTR|Ensembl=ENSPTRG00000030674|UniProtKB=H2R972	Bradykinin receptor B1	ISS	12130679	PubMed	PTHR24228:SF28	B1 BRADYKININ RECEPTOR
P00034	Integrin signalling pathway	P00907	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00807	Actin	TRIAD|EnsemblGenome=TriadG35956|UniProtKB=Q7YTV5	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	CANLF|Ensembl=ENSCAFG00000011236|UniProtKB=E2R9F8	Uncharacterized protein	ISS	9554852	PubMed	PTHR10845:SF103	AXIN-2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	ARATH|TAIR=AT4G38530|UniProtKB=Q56W08	Phosphoinositide phospholipase C 3	ISS			PTHR10336:SF105	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00709	Glycogen synthase D	CANLF|Ensembl=ENSCAFG00000003858|UniProtKB=E2RT20	Uncharacterized protein	ISS	4212312	PubMed	PTHR10176:SF2	GLYCOGEN  STARCH  SYNTHASE, MUSCLE
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01020	NSF	YEAST|SGD=S000000284|UniProtKB=P18759	Vesicular-fusion protein SEC18	ISS	11348590	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P04393	Ras Pathway	P04567	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00049	Parkinson disease	P01242	Casein kinase I	DAPPU|EnsemblGenome=DAPPUDRAFT_301140|UniProtKB=E9HGM4	Putative uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00004	Alzheimer disease-presenilin pathway	P00125	Ire-1 C-terminal fragment	MACMU|Ensembl=ENSMMUG00000015185|UniProtKB=F6WBI3	Uncharacterized protein	ISS	10619423	PubMed	PTHR13954:SF17	SERINE/THREONINE-PROTEIN KINASE/ENDORIBONUCLEASE IRE1
P00057	Wnt signaling pathway	P01438	PP2A	CHICK|Ensembl=ENSGALG00000011840|UniProtKB=F1NLM6	Uncharacterized protein	ISS	8703017	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00020	FAS signaling pathway	P00616	Nuclear Lamin	CAEEL|WormBase=WBGene00003052|UniProtKB=Q21443	Lamin-1	TAS	11165516	PubMed	PTHR23239:SF234	LAMIN DM0-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=620023|UniProtKB=P10980	Muscarinic acetylcholine receptor M2	IDA	12181435	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	ARATH|TAIR=AT2G34890|UniProtKB=O64753	CTP synthase	ISS			PTHR11550:SF23	CTP SYNTHASE
P00047	PDGF signaling pathway	P01153	GSK3	ARATH|TAIR=AT5G26751|UniProtKB=P43288	Shaggy-related protein kinase alpha	ISS	12615961	PubMed	PTHR24057:SF13	SHAGGY-RELATED PROTEIN KINASE ALPHA-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00539	14-3-3	CAEEL|WormBase=WBGene00001502|UniProtKB=Q20655	14-3-3-like protein 2	IGI	10407019	PubMed	PTHR18860:SF13	14-3-3 PROTEIN ZETA
P00059	p53 pathway	P04612	HDAC1	CANLF|Ensembl=ENSCAFG00000010597|UniProtKB=J9NUI0	Histone deacetylase	ISS	10485845	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P00023	General transcription regulation	P00666	TFIIE	HUMAN|HGNC=4650|UniProtKB=P29083	General transcription factor IIE subunit 1	ISS	189962	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01087	CAT	RAT|RGD=1304627|UniProtKB=P32738	Choline O-acetyltransferase	IC	92155737	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00056	VEGF signaling pathway	P01408	Akt/PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ARATH|TAIR=AT5G09810|UniProtKB=P53492	Actin-7	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	MONDO|Ensembl=ENSMODG00000018459|UniProtKB=F7CU42	Uncharacterized protein	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00049	Parkinson disease	P01234	GRK	XENTR|Ensembl=ENSXETG00000030841|UniProtKB=F7C5A3	Protein-serine/threonine kinase	ISS	10852916	PubMed	PTHR24355:SF18	PROTEIN-SERINE/THREONINE KINASE
P00015	Circadian clock system	G01503	per	RAT|RGD=727863|UniProtKB=Q8CHI5	Period circadian protein homolog 1	ISS	12782655	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P00049	Parkinson disease	P01235	Fyn kinase	TAKRU|Ensembl=ENSTRUG00000003538|UniProtKB=H2S7D1	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF242	TYROSINE-PROTEIN KINASE FYNB
P00029	Huntington disease	G01535	PIG3	LEIMA|EnsemblGenome=LmjF.03.0570|UniProtKB=E9ACK2	Putative quinone oxidoreductase	TAS	12932731	PubMed	PTHR42975:SF1	QUINONE OXIDOREDUCTASE-RELATED
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MOUSE|MGI=MGI=1202876|UniProtKB=Q9Z1J1	Transcription factor 7-like 1	IEP	12356903	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00052	TGF-beta signaling pathway	P01288	FKBP12	RAT|RGD=2617|UniProtKB=Q62658	Peptidyl-prolyl cis-trans isomerase FKBP1A	ISS			PTHR10516:SF301	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	RAT|RGD=3188|UniProtKB=Q9QW30	Neurogenic locus notch homolog protein 2	IDA	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00054	Toll receptor signaling pathway	P01352	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000004742|UniProtKB=H2Q5K1	Phosphoinositide phospholipase C	ISS			PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IGI	7937853	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P05917	Opioid proopiomelanocortin pathway	P06004	Mu or Delta receptor	MOUSE|MGI=MGI=97438|UniProtKB=P32300	Delta-type opioid receptor	RCA	11259487	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000006009|UniProtKB=F6UDC8	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF272	CADHERIN-24
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00036	Interleukin signaling pathway	P00981	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02751	Lysine biosynthesis	P03009	Aspartokinase	THEMA|EnsemblGenome=TM_1518|UniProtKB=Q9X1K6	Aspartokinase	ISS			PTHR21499:SF3	ASPARTOKINASE
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	RCA	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00054	Toll receptor signaling pathway	P01369	MKK1	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02742	Tetrahydrofolate biosynthesis	P02945	Dihydropteroate synthase	BACSU|EnsemblGenome=BSU00770|UniProtKB=P28822	Dihydropteroate synthase	ISS			PTHR20941:SF1	FOLIC ACID SYNTHESIS PROTEIN FOL1
P00034	Integrin signalling pathway	P00925	MEK	ORNAN|Ensembl=ENSOANG00000007732|UniProtKB=F6PXH5	Uncharacterized protein (Fragment)	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=620656|UniProtKB=O88277	Protocadherin Fat 2	IDA	8120095	PubMed	PTHR24026:SF37	PROTOCADHERIN FAT 2
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	HUMAN|HGNC=9508|UniProtKB=P49768	Presenilin-1	IDA	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00015	Circadian clock system	P00505	Cry	RAT|RGD=620935|UniProtKB=Q923I8	Cryptochrome-2	IDA	14507900	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P06214	GBB signaling pathway	P06304	PUT	DROME|Gene=Dmel_CG7904|UniProtKB=A0A0B4KG59	Serine/threonine-protein kinase receptor	IEA	http://flybase.org/reports/FBgn0003169.html	Website	PTHR23255:SF70	SERINE/THREONINE-PROTEIN KINASE RECEPTOR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=1351339|UniProtKB=Q14BI2	Metabotropic glutamate receptor 2	ISS	20012997	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00585	ECE1-3	BOVIN|Ensembl=ENSBTAG00000002977|UniProtKB=P42891	Endothelin-converting enzyme 1	IGI	94340737	PubMed	PTHR11733:SF130	ENDOTHELIN-CONVERTING ENZYME 1
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	BOVIN|Gene=CTNNA1|UniProtKB=Q3MHM6	Catenin alpha-1	ISS	9362521	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P02751	Lysine biosynthesis	P03007	Diaminopimelate decarboxylase	ARATH|TAIR=AT3G14390|UniProtKB=Q949X7	Diaminopimelate decarboxylase 1, chloroplastic	ISS			PTHR43727:SF2	DIAMINOPIMELATE DECARBOXYLASE 1, CHLOROPLASTIC-RELATED
P06664	Gonadotropin-releasing hormone receptor pathway	P06834	MAP3Ks	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	RCA	8643568	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P05913	Enkephalin release	P05976	Enkephalin	HUMAN|HGNC=8831|UniProtKB=P01210	Proenkephalin-A	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00053	T cell activation	P01333	cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IDA	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00591	PLCbeta	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	IGI	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00035	Interferon-gamma signaling pathway	P00956	SOCS	PANTR|Ensembl=ENSPTRG00000006368|UniProtKB=H2Q8C3	Uncharacterized protein	ISS	10500304	PubMed	PTHR44282:SF2	SUPPRESSOR OF CYTOKINE SIGNALING 4
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01284	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05915	Opioid proenkephalin pathway	P05994	G-protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00005	Angiogenesis	P00219	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CANLF|Ensembl=ENSCAFG00000008756|UniProtKB=F2Z4N8	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00029	Huntington disease	P00780	Microtubule	CAEBR|Gene=CBG20196|UniProtKB=A8XX81	Protein CBR-TBB-2	ISS	12932731	PubMed	PTHR11588:SF84	TUBULIN BETA-2 CHAIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00029	Huntington disease	P00790	beta-Tubulin	PANTR|Ensembl=ENSPTRG00000027750|UniProtKB=H2QS82	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00018	EGF receptor signaling pathway	P00546	GAP	BOVIN|Ensembl=ENSBTAG00000015413|UniProtKB=F1N795	Uncharacterized protein	ISS	20475167	gi	PTHR10194:SF21	RAS GTPASE-ACTIVATING PROTEIN 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_188187|UniProtKB=E9GJ31	Guanine nucleotide binding protein, q polypeptide	ISS	9166716	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	IGI	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05918	p38 MAPK pathway	P06021	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000016097|UniProtKB=E1B9S9	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	XENTR|Xenbase=XB-GENE-486781|UniProtKB=F6XWP7	Uncharacterized protein	ISS	12356903	PubMed	PTHR10845:SF11	AXIN-1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DANRE|ZFIN=ZDB-GENE-000322-1|UniProtKB=Q9I8V1	Actin, alpha 1, skeletal muscle	IEP	11889139	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00030	Hypoxia response via HIF activation	P00824	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	PHYIT|EnsemblGenome=PITG_06376|UniProtKB=D0N4Q3	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta, putative	ISS	12081467	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00030	Hypoxia response via HIF activation	P00819	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	TAS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01242	Casein kinase I	RAT|RGD=62045|UniProtKB=Q99PS2	Casein kinase1 epsilon-2	IDA	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P05915	Opioid proenkephalin pathway	P05994	G-protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	RAT|RGD=3381|UniProtKB=P62716	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	CHICK|Ensembl=ENSGALG00000002859|UniProtKB=F6UBD2	Uncharacterized protein	ISS	15470041	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00047	PDGF signaling pathway	P01162	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00057	Wnt signaling pathway	P01443	Phospholipase C	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	ARATH|TAIR=AT5G61210|UniProtKB=Q9S7P9	SNAP25 homologous protein SNAP33	ISS			PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00006	Apoptosis signaling pathway	P00274	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000018202|UniProtKB=E2RPJ2	Mitogen-activated protein kinase	ISS	12912994	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DICPU|Gene=DICPUDRAFT_46519|UniProtKB=F0Z796	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00054	Toll receptor signaling pathway	P01340	TLR3	MACMU|Ensembl=ENSMMUG00000021762|UniProtKB=F7DWP4	Uncharacterized protein	ISS			PTHR44599:SF1	TOLL-LIKE RECEPTOR 3
P00005	Angiogenesis	P00223	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00981	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00752	cGMP-gated ion channel	MOUSE|MGI=MGI=1353562|UniProtKB=Q9JJZ9	Cyclic nucleotide-gated cation channel beta-3	IDA	12432397	PubMed	PTHR10217:SF385	CYCLIC NUCLEOTIDE-GATED CATION CHANNEL BETA-3
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=2683547|UniProtKB=Q4KWH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1	ISS	7822322	PubMed	PTHR10336:SF51	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-1
P00029	Huntington disease	P00807	Actin	PANTR|Ensembl=ENSPTRG00000018890|UniProtKB=Q5R1X3	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-9966|UniProtKB=Q6TH03	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P05731	GABA-B receptor II signaling	P05752	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	7925653	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04556	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	12068308	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	CANLF|Ensembl=ENSCAFG00000011590|UniProtKB=E2R7K9	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00034	Integrin signalling pathway	P00926	GRAF	BOVIN|Ensembl=ENSBTAG00000002531|UniProtKB=Q08DP6	Rho GTPase-activating protein 10	ISS	8649427	PubMed	PTHR12552:SF5	RHO GTPASE-ACTIVATING PROTEIN 10
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P05916	Opioid prodynorphin pathway	P06000	vasopressin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05916	Opioid prodynorphin pathway	P06002	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05938	RhoA	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	RCA	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	IC	8557110	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00059	p53 pathway	P04620	TRAF	DROME|FlyBase=FBgn0265464|UniProtKB=Q9W3I9	GH01161p	ISS			PTHR10131:SF111	TNF RECEPTOR-ASSOCIATED FACTOR 6
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MACMU|Ensembl=ENSMMUG00000000846|UniProtKB=F6Q1E0	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR15936:SF2	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-13
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00047	PDGF signaling pathway	P01174	Rho	MACMU|Ensembl=ENSMMUG00000018366|UniProtKB=F7H3I5	Oligophrenin-1	ISS			PTHR12552:SF2	OLIGOPHRENIN-1
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=69319|UniProtKB=P54313	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00029	Huntington disease	P00774	Dynein complex	BOVIN|Ensembl=ENSBTAG00000014063|UniProtKB=E1B9R5	Uncharacterized protein	ISS	9454836	PubMed	PTHR10676:SF344	DYNEIN HEAVY CHAIN 8, AXONEMAL
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	CAEEL|WormBase=WBGene00000913|UniProtKB=G5EE01	DAF-18	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00012	Cadherin signaling pathway	P00470	F-actin	RAT|RGD=1309504|UniProtKB=D3ZRN3	Protein Actbl2	ISS	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IPI	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04558	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00057	Wnt signaling pathway	P01451	Galpha	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	TAS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00029	Huntington disease	P00771	Sin3A	MACMU|Ensembl=ENSMMUG00000018504|UniProtKB=F6YZ56	Uncharacterized protein	ISS	10441327	PubMed	PTHR12346:SF1	PAIRED AMPHIPATHIC HELIX PROTEIN SIN3B
P04398	p53 pathway feedback loops 2	P04661	PI3K	CAEEL|WormBase=WBGene00006932|UniProtKB=Q9TXI7	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00010	B cell activation	P00391	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00631	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	9763606	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000018202|UniProtKB=E2RPJ2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	HUMAN|HGNC=7881|UniProtKB=P46531	Neurogenic locus notch homolog protein 1	IDA	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MONDO|Ensembl=ENSMODG00000012331|UniProtKB=F7E2P1	Phosphoinositide phospholipase C	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P00053	T cell activation	P01307	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00036	Interleukin signaling pathway	P00983	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00024	Glycolysis	P00679	Aldolase	CANLF|Ensembl=ENSCAFG00000018144|UniProtKB=F1PNI3	Uncharacterized protein	ISS	6086339	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00019	Endothelin signaling pathway	P00589	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00562	p38	CAEBR|Gene=CBG01555|UniProtKB=A8WRD7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	DROME|FlyBase=FBgn0000044|UniProtKB=P53501	Actin-57B	IC	11889126	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P06959	CCKR signaling map	P07181	SRF	HUMAN|HGNC=11291|UniProtKB=P11831	Serum response factor	RCA	12239223	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00047	PDGF signaling pathway	P01174	Rho	RAT|RGD=1563152|UniProtKB=F1M5M9	Protein Srgap3	ISS			PTHR14166:SF8	SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 3
P00029	Huntington disease	P00807	Actin	TAKRU|Ensembl=ENSTRUG00000004787|UniProtKB=P53480	Actin, alpha cardiac	IDA	10974003	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00059	p53 pathway	G04696	Siah	RAT|RGD=620449|UniProtKB=Q920M9	E3 ubiquitin-protein ligase SIAH1	ISS	14985507	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00036	Interleukin signaling pathway	P00973	PKB	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IDA	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00018	EGF receptor signaling pathway	P00547	PP2A	PANTR|Ensembl=ENSPTRG00000017238|UniProtKB=H2QRH7	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	PSEAE|EnsemblGenome=PA3759|UniProtKB=Q9HXN6	Probable aminotransferase	ISS			PTHR10937:SF8	SUBFAMILY NOT NAMED
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	SYNY3|EnsemblGenome=BAA18596|UniProtKB=P74494	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	MONDO|Ensembl=ENSMODG00000019001|UniProtKB=F7CP86	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	CANLF|Ensembl=ENSCAFG00000013171|UniProtKB=E2RP04	Uncharacterized protein	ISS	10480933	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P04397	p53 pathway by glucose deprivation	P04641	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00775	Rac	SCHPO|PomBase=SPAC110.03|UniProtKB=Q01112	Cell division control protein 42 homolog	TAS			PTHR24072:SF192	CDC42 HOMOLOG
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	RAT|RGD=621005|UniProtKB=Q08849	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01369	MKK1	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00057	Wnt signaling pathway	P01444	Wnt	MONDO|Ensembl=ENSMODG00000015792|UniProtKB=Q2QL96	Protein Wnt-2	ISS	8717036	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00018	EGF receptor signaling pathway	P00565	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IGI	7492337	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	IDA	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04570	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	TAS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05915	Opioid proenkephalin pathway	P05988	peptide E	BOVIN|Ensembl=ENSBTAG00000004924|UniProtKB=P01211	Proenkephalin-A	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04393	Ras Pathway	P04563	Ets	RAT|RGD=2583|UniProtKB=P41156	Protein C-ets-1	IDA	15298723	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04398	p53 pathway feedback loops 2	P04651	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	P01454	betaTrCP	HUMAN|HGNC=1144|UniProtKB=Q9Y297	F-box/WD repeat-containing protein 1A	IDA	10074433	PubMed	PTHR44038:SF2	F-BOX/WD REPEAT-CONTAINING PROTEIN 1A
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MOUSE|MGI=MGI=1341110|UniProtKB=P97490	Adenylate cyclase type 8	ISS	2491850	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00048	PI3 kinase pathway	P01177	P110ACT	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00645	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04373	5HT1 type receptor mediated signaling pathway	P04407	K+ channel	HUMAN|HGNC=6278|UniProtKB=O14649	Potassium channel subfamily K member 3	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00890	ELK	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	11050086	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MACMU|Ensembl=ENSMMUG00000014807|UniProtKB=F6W548	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IDA	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00049	Parkinson disease	P01211	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	97449291	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00047	PDGF signaling pathway	P01148	Grb2	MACMU|Ensembl=ENSMMUG00000004880|UniProtKB=F7AN37	GRB2-related adapter protein 2	ISS	51702266	gi	PTHR24418:SF299	GRB2-RELATED ADAPTER PROTEIN 2
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	HUMAN|HGNC=2519|UniProtKB=P17812	CTP synthase 1	ISS			PTHR11550:SF8	CTP SYNTHASE 1
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04393	Ras Pathway	P04553	PAK	BOVIN|Ensembl=ENSBTAG00000015670|UniProtKB=E1B7J7	Uncharacterized protein	ISS	11259591	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CHICK|Ensembl=ENSGALG00000012894|UniProtKB=P30372	Muscarinic acetylcholine receptor M2	IDA			PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05730	Endogenous cannabinoid signaling	P05748	mGluR	HUMAN|HGNC=4597|UniProtKB=P41594	Metabotropic glutamate receptor 5	ISS	92317054	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	MACMU|Ensembl=ENSMMUG00000015925|UniProtKB=F7AL30	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P00011	Blood coagulation	P00418	Fibrin monomer	HUMAN|HGNC=3694|UniProtKB=P02679	Fibrinogen gamma chain	ISS	223170	gi	PTHR19143:SF338	FIBRINOGEN GAMMA CHAIN
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g247341|UniProtKB=A7STP5	Predicted protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P04393	Ras Pathway	P04570	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	MONDO|Ensembl=ENSMODG00000019823|UniProtKB=F6SB23	Uncharacterized protein (Fragment)	ISS	94365697	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P06959	CCKR signaling map	P07206	Pro-CCK @ secretory granule	HUMAN|HGNC=1569|UniProtKB=P06307	Cholecystokinin	RCA	12479974	PubMed	PTHR10786:SF0	CHOLECYSTOKININ
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IGI	9516481	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9062|UniProtKB=Q9BRC7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	10934033	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00018	EGF receptor signaling pathway	P00560	Raf-1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IGI	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00634	MEKK1-5	MOUSE|MGI=MGI=1346875|UniProtKB=O08648	Mitogen-activated protein kinase kinase kinase 4	IGI	11730323	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00010	B cell activation	P00385	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00025	Hedgehog signaling pathway	P00682	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04558	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00054	Toll receptor signaling pathway	P01355	AP1	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	HUMAN|HGNC=12336|UniProtKB=Q9UBN4	Short transient receptor potential channel 4	IDA	11055438	PubMed	PTHR10117:SF25	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 4
P00046	Oxidative stress response	P01131	MKP5	HUMAN|HGNC=16077|UniProtKB=Q9NRW4	Dual specificity protein phosphatase 22	ISS			PTHR10159:SF29	DUAL SPECIFICITY PROTEIN PHOSPHATASE 22
P00059	p53 pathway	P01486	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00025	Hedgehog signaling pathway	P00683	Slimb	ANOGA|EnsemblGenome=AGAP001944|UniProtKB=Q7PYH7	AGAP001944-PA	ISS	10074433	PubMed	PTHR44038:SF2	F-BOX/WD REPEAT-CONTAINING PROTEIN 1A
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00012	Cadherin signaling pathway	P00470	F-actin	ORNAN|Ensembl=ENSOANG00000007716|UniProtKB=F6UDX9	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	PANTR|Ensembl=ENSPTRG00000020122|UniProtKB=H2QVZ0	Uncharacterized protein	ISS	12549854	PubMed	PTHR11309:SF22	FRIZZLED-3
P00029	Huntington disease	P00782	alpha-Adaptin	NEUCR|EnsemblGenome=EFNCRG00000002547|UniProtKB=Q1K5B2	AP-2 complex subunit alpha	IDA	11532990	PubMed	PTHR22780:SF4	AP-2 COMPLEX SUBUNIT ALPHA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	PANTR|Ensembl=ENSPTRG00000012931|UniProtKB=H2QJF8	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000008270|UniProtKB=H2QBE5	Uncharacterized protein	ISS	12834808	PubMed	PTHR24027:SF319	CADHERIN-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00018	EGF receptor signaling pathway	P00562	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IGI	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	20855874	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00387	CD22	HUMAN|HGNC=1643|UniProtKB=P20273	B-cell receptor CD22	IPI	11551923	PubMed	PTHR12035:SF60	B-CELL RECEPTOR CD22
P00057	Wnt signaling pathway	P01443	Phospholipase C	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04393	Ras Pathway	P04571	Tiam1	PANTR|Ensembl=ENSPTRG00000013846|UniProtKB=H2QKY3	T-cell lymphoma invasion and metastasis 1	ISS	11130063	PubMed	PTHR22826:SF88	T-LYMPHOMA INVASION AND METASTASIS-INDUCING PROTEIN 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=2444314|UniProtKB=Q8BNA6	Protocadherin Fat 3	ISS	8120095	PubMed	PTHR24026:SF49	PROTOCADHERIN FAT 3
P00034	Integrin signalling pathway	P00913	Csk	PANTR|Ensembl=ENSPTRG00000007282|UniProtKB=H2Q9T1	Tyrosine-protein kinase	ISS	12665526	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=107469|UniProtKB=Q8K3R3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	12860966	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00034	Integrin signalling pathway	P00925	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01471	alpha-catenin	HUMAN|HGNC=2510|UniProtKB=P26232	Catenin alpha-2	IDA	1638632	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IDA	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CANLF|Ensembl=ENSCAFG00000031321|UniProtKB=J9NZJ2	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P00036	Interleukin signaling pathway	P00977	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P05915	Opioid proenkephalin pathway	P05994	G-protein	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=2683547|UniProtKB=Q4KWH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1	ISS	15611108	PubMed	PTHR10336:SF51	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02738	De novo purine biosynthesis	P02902	ADP reductase	DICDI|dictyBase=DDB_G0272616|UniProtKB=P42521	Ribonucleoside-diphosphate reductase small subunit	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01199	Galpha	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00034	Integrin signalling pathway	P00949	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00029	Huntington disease	P00790	beta-Tubulin	PHYPA|Gene=PHYPADRAFT_223212|UniProtKB=Q6TYR5	Beta-tubulin 3	ISS	12932731	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	FUSNN|EnsemblGenome=FN1220|UniProtKB=Q8RE94	Cysteine synthase	ISS			PTHR10314:SF159	CYSTEINE SYNTHASE A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	RCA			PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00057	Wnt signaling pathway	P01457	GBeta	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IDA	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04552	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00047	PDGF signaling pathway	P01142	p90RSK	HUMAN|HGNC=10436|UniProtKB=P23443	Ribosomal protein S6 kinase beta-1	ISS	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00006	Apoptosis signaling pathway	P00316	Bcl-w	XENTR|Xenbase=XB-GENE-992427|UniProtKB=F6TEC3	Uncharacterized protein (Fragment)	ISS	7607538	PubMed	PTHR11256:SF13	BCL-2-LIKE PROTEIN 2
P00056	VEGF signaling pathway	P01417	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00004	Alzheimer disease-presenilin pathway	P00121	CD44 intracellular fragment	PANTR|Ensembl=ENSPTRG00000003501|UniProtKB=H2Q3E8	Uncharacterized protein	ISS	12223485	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	MACMU|Ensembl=ENSMMUG00000015658|UniProtKB=F7AJI7	Uncharacterized protein	ISS	6382022	PubMed	PTHR15071:SF17	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
P05913	Enkephalin release	P05972	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00034	Integrin signalling pathway	P00924	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00546	GAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	IGI	227170	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04397	p53 pathway by glucose deprivation	P04641	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IGI	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MONDO|Ensembl=ENSMODG00000016895|UniProtKB=F6XII5	Uncharacterized protein	ISS	10391901	PubMed	PTHR15936:SF2	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-13
P00046	Oxidative stress response	P01126	ATF2	PANTR|Ensembl=ENSPTRG00000012660|UniProtKB=H2QJ07	Activating transcription factor 2	ISS	10664585	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00034	Integrin signalling pathway	P00916	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IPI	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	RAT|RGD=2343|UniProtKB=P08483	Muscarinic acetylcholine receptor M3	IDA	10069496	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04395	Vasopressin synthesis	P04599	Amidating Enzyme	MACMU|Ensembl=ENSMMUG00000002113|UniProtKB=F6UX60	NHL repeat-containing protein 3	ISS			PTHR24104:SF8	NHL REPEAT-CONTAINING PROTEIN 3
P04396	Vitamin D metabolism and pathway	P04604	FdxR	MYCTU|EnsemblGenome=Rv3106|UniProtKB=P9WIQ3	NADPH-ferredoxin reductase FprA	ISS			PTHR11938:SF114	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00551	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	IGI	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04579	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	8264585	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	BOVIN|Ensembl=ENSBTAG00000010191|UniProtKB=Q08E52	Serine/threonine-protein kinase PAK 1	ISS	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00005	Angiogenesis	P00243	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00391	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PHYPA|Gene=PHYPADRAFT_198730|UniProtKB=Q6TYS2	Actin 1	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=621025|UniProtKB=Q62711	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	10934033	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P06211	BMP/activin signaling pathway-drosophila	P06256	Full-length  BMP orthologous ligand	DROME|FlyBase=FBgn0005590|UniProtKB=P54631	Protein screw	RCA	http://flybase.org/reports/FBgn0005590.html	Website	PTHR11848:SF54	PROTEIN 60A-RELATED
P00059	p53 pathway	G04702	p53	DANRE|ZFIN=ZDB-GENE-030814-2|UniProtKB=B0S576	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00021	FGF signaling pathway	P00644	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	PANTR|Ensembl=ENSPTRG00000002993|UniProtKB=H2Q2N7	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF27	G PROTEIN-COUPLED RECEPTOR KINASE 5
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00750	Rhodopsin kinase	DROME|FlyBase=FBgn0260798|UniProtKB=P32865	G protein-coupled receptor kinase 1	IDA			PTHR24355:SF18	PROTEIN-SERINE/THREONINE KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	MOUSE|MGI=MGI=1351340|UniProtKB=Q9QYS2	Metabotropic glutamate receptor 3	ISS	12351712	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT4G01370|UniProtKB=Q39024	Mitogen-activated protein kinase 4	IDA	9836510	gi	PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	ARATH|TAIR=AT5G58670|UniProtKB=Q39032	Phosphoinositide phospholipase C 1	ISS			PTHR10336:SF105	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_116948|UniProtKB=C3YKS6	Putative uncharacterized protein	ISS			PTHR11937:SF359	SUBFAMILY NOT NAMED
P00050	Plasminogen activating cascade	P01264	alpha2 antiplasmin	MACMU|Ensembl=ENSMMUG00000002382|UniProtKB=F7BTD3	Uncharacterized protein	ISS	11386143	gi	PTHR11461:SF20	ALPHA-2-ANTIPLASMIN
P00019	Endothelin signaling pathway	P00586	Gq	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00006	Apoptosis signaling pathway	P00267	MADD	PANTR|Ensembl=ENSPTRG00000003561|UniProtKB=H2QZL1	Uncharacterized protein	ISS	9115275	PubMed	PTHR13008:SF7	MAP KINASE-ACTIVATING DEATH DOMAIN PROTEIN
P00005	Angiogenesis	P00223	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00095	Nicastrin	CAEEL|WormBase=WBGene00000148|UniProtKB=Q23316	Nicastrin	IDA	16096062	PubMed	PTHR21092:SF0	NICASTRIN
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01208	Hsp70	HUMAN|HGNC=5238|UniProtKB=P11021	78 kDa glucose-regulated protein	IDA	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-7595|UniProtKB=Q6PBR4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P05912	Dopamine receptor mediated signaling pathway	P05961	DOPA decarb.	MOUSE|MGI=MGI=94876|UniProtKB=O88533	Aromatic-L-amino-acid decarboxylase	ISS	90339966	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05915	Opioid proenkephalin pathway	P05990	K+ channel	MOUSE|MGI=MGI=3521816|UniProtKB=Q3LS21	Potassium channel subfamily K member 9	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00018	EGF receptor signaling pathway	P00549	EGF	HUMAN|HGNC=29862|UniProtKB=Q8WWG1	Pro-neuregulin-4, membrane-bound isoform	RCA			PTHR11100:SF20	PRO-NEUREGULIN-2, MEMBRANE-BOUND ISOFORM-RELATED
P00059	p53 pathway	P01483	Mdm2	MACMU|Ensembl=ENSMMUG00000011236|UniProtKB=F6WXF0	Uncharacterized protein	ISS			PTHR13844:SF20	PROTEIN MDM4
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	RAT|RGD=621705|UniProtKB=Q8VHN2	Glutamate receptor ionotropic, NMDA 3B	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	HUMAN|HGNC=172|UniProtKB=P36896	Activin receptor type-1B	TAS	9395284	PubMed	PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P00005	Angiogenesis	P00205	GAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MOUSE|MGI=MGI=1277207|UniProtKB=O88410	C-X-C chemokine receptor type 3	IDA	12538721	PubMed	PTHR10489:SF671	C-X-C CHEMOKINE RECEPTOR TYPE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00012	Cadherin signaling pathway	P00470	F-actin	CIOIN|Ensembl=ENSCING00000000848|UniProtKB=F6SCP4	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00054	Toll receptor signaling pathway	P01352	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05731	GABA-B receptor II signaling	P05754	Ggamma	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00057	Wnt signaling pathway	P01446	Calcineurin	ARATH|TAIR=AT4G16350|UniProtKB=Q9C5P6	Calcineurin B-like protein 6	IDA	12015605	PubMed	PTHR23056:SF51	CALCINEURIN B-LIKE PROTEIN 2-RELATED
P00005	Angiogenesis	P00203	Erk	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01235	Fyn kinase	PANTR|Ensembl=ENSPTRG00000018511|UniProtKB=H2QTK7	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00010	B cell activation	P00391	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01312	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00010	B cell activation	P00381	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	G04694	p110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02726	Aminobutyrate degradation	P02824	Succinate semi-aldehyde dehydrogenase	HUMAN|HGNC=408|UniProtKB=P51649	Succinate-semialdehyde dehydrogenase, mitochondrial	ISS	12891648	PubMed	PTHR43353:SF5	SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL
P00049	Parkinson disease	P01230	Src kinase	MOUSE|MGI=MGI=98397|UniProtKB=P05480	Neuronal proto-oncogene tyrosine-protein kinase Src	IDA	11078745	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00010	B cell activation	P00391	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00570	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00048	PI3 kinase pathway	P01177	P110ACT	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00397	IKK	HUMAN|HGNC=5960|UniProtKB=O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	IGI	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=109356|UniProtKB=O09044	Synaptosomal-associated protein 23	IC	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DICDI|dictyBase=DDB_G0279413|UniProtKB=P05987	cAMP-dependent protein kinase regulatory subunit	IC	91298951	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	TAKRU|Ensembl=ENSTRUG00000015938|UniProtKB=H2UUX5	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	TAS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00034	Integrin signalling pathway	P00910	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05957	K+ channel	BOVIN|Ensembl=ENSBTAG00000047488|UniProtKB=G3N1D1	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	RAT|RGD=2025|UniProtKB=P68136	Actin, alpha skeletal muscle	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	RAT|RGD=1305887|UniProtKB=Q4QQV0	Protein Tubb6	ISS	12932731	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IDA	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000005792|UniProtKB=F6VTR8	Uncharacterized protein	ISS	12507995	PubMed	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	XENTR|Xenbase=XB-GENE-854877|UniProtKB=F7C949	Presenilin	ISS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00761	Truncated Htt	RAT|RGD=68337|UniProtKB=P51111	Huntingtin	TAS	7620118	PubMed	PTHR10170:SF10	HUNTINGTIN
P00029	Huntington disease	P00796	Kainate receptor	CANLF|Ensembl=ENSCAFG00000003333|UniProtKB=F1PWT6	Uncharacterized protein	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00562	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	IPI	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	ISS	11319238	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04393	Ras Pathway	P04552	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IDA	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00019	Endothelin signaling pathway	P00591	PLCbeta	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04395	Vasopressin synthesis	P04594	Neurophysin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00057	Wnt signaling pathway	P01428	Frizzled	CANLF|Gene=FZD6|UniProtKB=Q8WMU5	Frizzled-6	IDA	8717036	PubMed	PTHR11309:SF75	FRIZZLED-6
P00010	B cell activation	P00388	PLC gamma2	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	IDA	10851062	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	DROME|FlyBase=FBgn0028743|UniProtKB=Q8T017	Double hit, isoform B	IDA	8756726	PubMed	PTHR10845:SF192	AXIN-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00012	Cadherin signaling pathway	P00477	GSK3beta	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IC	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00634	MEKK1-5	CAEEL|WormBase=WBGene00003822|UniProtKB=Q21029	Mitogen-activated protein kinase kinase kinase nsy-1	ISS			PTHR11584:SF369	APOPTOTIC SIGNAL-REGULATING KINASE 1, ISOFORM C
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=98329|UniProtKB=P30935	Somatostatin receptor type 3	IDA	12562507	PubMed	PTHR24229:SF42	SOMATOSTATIN RECEPTOR TYPE 3
P00035	Interferon-gamma signaling pathway	P00961	STAT1	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	14755057	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00054	Toll receptor signaling pathway	P01351	TLR2,4,7	MACMU|Gene=TLR2|UniProtKB=B3Y618	Toll-like receptor 2	ISS			PTHR24365:SF17	TOLL-LIKE RECEPTOR 2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00015	Circadian clock system	P00502	Casein kinase I	DROME|FlyBase=FBgn0002413|UniProtKB=O76324	Discs overgrown protein kinase	IDA	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00059	p53 pathway	G04694	p110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04633	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DANRE|ZFIN=ZDB-GENE-040426-1489|UniProtKB=Q6PHV0	Syntaxin 3A	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00053	T cell activation	P01330	IKK	MOUSE|MGI=MGI=99484|UniProtKB=Q60680	Inhibitor of nuclear factor kappa-B kinase subunit alpha	IGI	12813046	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	SCHPO|PomBase=SPBC32H8.12c|UniProtKB=P10989	Actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05916	Opioid prodynorphin pathway	P06002	G-protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	ISS	10704417	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P04393	Ras Pathway	P04546	GSK3	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00036	Interleukin signaling pathway	P00973	PKB	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00307	ELF2alpha	METAC|EnsemblGenome=MA_0644|UniProtKB=Q8TSZ9	Translation initiation factor 2, subunit alpha	ISS			PTHR10602:SF0	EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1
P05912	Dopamine receptor mediated signaling pathway	P05959	FLNA	BOVIN|Ensembl=ENSBTAG00000011190|UniProtKB=F1N169	Uncharacterized protein	ISS	11911837	PubMed	PTHR43998:SF6	FILAMIN-A
P00019	Endothelin signaling pathway	P00572	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00057	Wnt signaling pathway	P01448	CBP	PANTR|Ensembl=ENSPTRG00000014418|UniProtKB=H2QLS0	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00053	T cell activation	P01322	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00189	Fzd	MACMU|Ensembl=ENSMMUG00000022114|UniProtKB=F7H7V5	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF81	FRIZZLED-1
P00007	Axon guidance mediated by semaphorins	P00337	Sema3A	MACMU|Ensembl=ENSMMUG00000007555|UniProtKB=F6T171	Uncharacterized protein	ISS	7748562	PubMed	PTHR11036:SF23	SEMAPHORIN-3A
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PLAF7|EnsemblGenome=PFL2215w|UniProtKB=Q8I4X0	Actin-1	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04393	Ras Pathway	P04572	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04398	p53 pathway feedback loops 2	P04663	Mdm2	MOUSE|MGI=MGI=107934|UniProtKB=O35618	Protein Mdm4	ISS			PTHR13844:SF20	PROTEIN MDM4
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	HUMAN|HGNC=4588|UniProtKB=O15399	Glutamate receptor ionotropic, NMDA 2D	IC	11319238	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	PANTR|Ensembl=ENSPTRG00000012128|UniProtKB=H2QI87	Uncharacterized protein	ISS	12356903	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00029	Huntington disease	P00807	Actin	BOVIN|Ensembl=ENSBTAG00000006189|UniProtKB=P63258	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00029	Huntington disease	P00807	Actin	EMENI|EnsemblGenome=CADANIAG00007315|UniProtKB=P20359	Actin, gamma	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00892	Grb2	DANRE|ZFIN=ZDB-GENE-040426-1975|UniProtKB=Q6PC73	Growth factor receptor-bound protein 2	ISS	4504111	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00562	p38	CAEEL|WormBase=WBGene00004056|UniProtKB=Q8MXI4	Mitogen-activated protein kinase pmk-2	ISS	11274345	PubMed	PTHR24055:SF154	MITOGEN-ACTIVATED PROTEIN KINASE PMK-2
P02738	De novo purine biosynthesis	P02904	Guanylate kinase	CAEEL|WormBase=WBGene00020190|UniProtKB=P91425	GUanylate Kinase	ISS			PTHR23117:SF13	GUANYLATE KINASE
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00587	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00552	Ras	SCLS1|EnsemblGenome=SS1G_13801|UniProtKB=A7F871	Uncharacterized protein	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	CAEEL|WormBase=WBGene00004769|UniProtKB=P52166	Presenilin sel-12	TAS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00021	FGF signaling pathway	P00634	MEKK1-5	BOVIN|Ensembl=ENSBTAG00000013790|UniProtKB=E1B847	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00034	Integrin signalling pathway	P00925	MEK	PANTR|Ensembl=ENSPTRG00000008783|UniProtKB=H2QCA7	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00021	FGF signaling pathway	P00629	PP2A	PLAF7|EnsemblGenome=PFI1245c|UniProtKB=Q8I2Q4	Serine/threonine-protein phosphatase	ISS			PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00810	GAPDH	STRCO|Gene=CAC01538|UniProtKB=Q9FC43	Glyceraldehyde-3-phosphate dehydrogenase	ISS			PTHR43454:SF1	SUBFAMILY NOT NAMED
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000014579|UniProtKB=F7GRK8	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF55	PROTOCADHERIN BETA-4
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01448	CBP	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_58093|UniProtKB=C3Z4K3	Putative uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00046	Oxidative stress response	P01134	cPLA2	MACMU|Ensembl=ENSMMUG00000003842|UniProtKB=F7HAF3	Phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF32	CYTOSOLIC PHOSPHOLIPASE A2 BETA
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00005	Angiogenesis	P00203	Erk	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	MACMU|Ensembl=ENSMMUG00000009784|UniProtKB=F6Y1K4	C-C motif chemokine	ISS			PTHR12015:SF144	C-C MOTIF CHEMOKINE 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	RAT|RGD=2347|UniProtKB=P20420	Neuronal acetylcholine receptor subunit alpha-5	IC	85270494	PubMed	PTHR18945:SF76	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5
P04392	P53 pathway feedback loops 1	P04539	p53	PANTR|Ensembl=ENSPTRG00000015733|UniProtKB=H2QNY5	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00944	Actin	BOVIN|Ensembl=ENSBTAG00000014614|UniProtKB=P62739	Actin, aortic smooth muscle	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	ORNAN|Ensembl=ENSOANG00000007724|UniProtKB=F6QTB5	Uncharacterized protein	ISS	12932731	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	RAT|RGD=2736|UniProtKB=P35439	Glutamate receptor ionotropic, NMDA 1	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05916	Opioid prodynorphin pathway	P06002	G-protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	P01457	GBeta	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00005	Angiogenesis	P00190	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MOUSE|MGI=MGI=88177|UniProtKB=P21274	Bone morphogenetic protein 2	TAS	9759503	PubMed	PTHR11848:SF143	BONE MORPHOGENETIC PROTEIN 2
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00057	Wnt signaling pathway	P01451	Galpha	MOUSE|MGI=MGI=95770|UniProtKB=P30678	Guanine nucleotide-binding protein subunit alpha-15	IDA	10629036	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=1351339|UniProtKB=Q14BI2	Metabotropic glutamate receptor 2	ISS	12488551	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00005	Angiogenesis	P00200	Dsh	CANLF|Ensembl=ENSCAFG00000019275|UniProtKB=E2QY91	Uncharacterized protein	ISS	12549854	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P00005	Angiogenesis	P00211	GSK3beta	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00057	Wnt signaling pathway	P01438	PP2A	TAKRU|Ensembl=ENSTRUG00000003840|UniProtKB=H2S9H8	Uncharacterized protein	ISS	8703017	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347736|UniProtKB=E9FRT1	Muscle-specific actin	ISS	10974003	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IDA	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00053	T cell activation	P01318	PKC-theta	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IGI	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05918	p38 MAPK pathway	P06020	p38delta	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00049	Parkinson disease	P01212	p38 MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	HUMAN|HGNC=10002|UniProtKB=P49758	Regulator of G-protein signaling 6	IDA	8756726	PubMed	PTHR10845:SF27	REGULATOR OF G-PROTEIN SIGNALING 6
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	DROME|FlyBase=FBgn0004623|UniProtKB=P29829	Guanine nucleotide-binding protein subunit beta-2	ISS	11313908	PubMed	PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00041	Metabotropic glutamate receptor group I pathway	P01062	mGluR1	MOUSE|MGI=MGI=1351338|UniProtKB=P97772	Metabotropic glutamate receptor 1	ISS	12488551	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	ANOGA|EnsemblGenome=AGAP005912|UniProtKB=Q7Q6D3	AGAP005912-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	MOUSE|MGI=MGI=96433|UniProtKB=Q60751	Insulin-like growth factor 1 receptor	ISS	11182407	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MOUSE|MGI=MGI=95818|UniProtKB=Q61626	Glutamate receptor ionotropic, kainate 5	ISS	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00052	TGF-beta signaling pathway	P01275	P38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_188187|UniProtKB=E9GJ31	Guanine nucleotide binding protein, q polypeptide	ISS	1333286	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	PANTR|Ensembl=ENSPTRG00000029367|UniProtKB=H2R6V7	Regulator of G-protein signaling 17	ISS	8756726	PubMed	PTHR10845:SF196	REGULATOR OF G-PROTEIN SIGNALING 17
P00053	T cell activation	P01333	cdc42	HUMAN|HGNC=1736|UniProtKB=P60953	Cell division control protein 42 homolog	IDA	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00018	EGF receptor signaling pathway	P00539	14-3-3	PLAF7|EnsemblGenome=MAL8P1.69|UniProtKB=C0H4V6	14-3-3 protein	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00034	Integrin signalling pathway	P00920	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IDA	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00049	Parkinson disease	P01227	20S proteasome	TAKRU|Ensembl=ENSTRUG00000008786|UniProtKB=H2TBN4	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF15	PROTEASOME SUBUNIT ALPHA TYPE
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01153	GSK3	ARATH|TAIR=AT3G61160|UniProtKB=O23145	Shaggy-related protein kinase beta	ISS	12615961	PubMed	PTHR24057:SF19	SHAGGY-RELATED PROTEIN KINASE BETA-RELATED
P00034	Integrin signalling pathway	P00920	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9060|UniProtKB=P51178	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	15611108	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	LEIMA|EnsemblGenome=LmjF.19.1560|UniProtKB=Q4QD53	Inosine-5'-monophosphate dehydrogenase	ISS			PTHR11911:SF111	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	PANTR|Ensembl=ENSPTRG00000004775|UniProtKB=H2Q5M1	Uncharacterized protein	ISS	6287573	PubMed	PTHR24070:SF186	GTPASE KRAS
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	XENTR|Xenbase=XB-GENE-1031985|UniProtKB=Q6GL68	Transcription factor 7-like 1	ISS	9118222	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00029	Huntington disease	P00810	GAPDH	CAEEL|WormBase=WBGene00001683|UniProtKB=P04970	Glyceraldehyde-3-phosphate dehydrogenase 1	IPI			PTHR10836:SF65	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE 1-RELATED
P00005	Angiogenesis	P00251	cPLA2	CANLF|Ensembl=ENSCAFG00000013778|UniProtKB=F6UQ33	Phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	DANRE|ZFIN=ZDB-GENE-040718-414|UniProtKB=D7RVR6	Excitatory amino acid transporter SLC1A1	ISS	94365697	PubMed	PTHR11958:SF69	EXCITATORY AMINO ACID TRANSPORTER 3
P04393	Ras Pathway	P04558	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IDA	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00018	EGF receptor signaling pathway	P00564	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12176041	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00005	Angiogenesis	P00211	GSK3beta	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IDA	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00054	Toll receptor signaling pathway	P01358	ERK1	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00008	Axon guidance mediated by Slit/Robo	P00351	Cxcr4	MOUSE|MGI=MGI=109563|UniProtKB=P70658	C-X-C chemokine receptor type 4	ISS	4503175	gi	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P05731	GABA-B receptor II signaling	P05760	AC	MONDO|Ensembl=ENSMODG00000001430|UniProtKB=F7BCI5	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00007	Axon guidance mediated by semaphorins	P00332	Fes	MOUSE|MGI=MGI=95514|UniProtKB=P16879	Tyrosine-protein kinase Fes/Fps	ISS			PTHR24418:SF197	TYROSINE-PROTEIN KINASE FES/FPS
P00019	Endothelin signaling pathway	P00586	Gq	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00045	Notch signaling pathway	P01103	Next	MACMU|Ensembl=ENSMMUG00000013637|UniProtKB=F7GL52	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01087	CAT	CAEEL|WormBase=WBGene00007175|UniProtKB=Q17499	Uncharacterized protein	ISS			PTHR22589:SF103	CARNITINE O-ACETYL-TRANSFERASE, ISOFORM A
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	ORNAN|Ensembl=ENSOANG00000007405|UniProtKB=F7CIV4	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P02746	Heme biosynthesis	P02975	Uroporphyrinogen decarboxylase	GLOVI|EnsemblGenome=BAC91818|UniProtKB=Q7NEK2	Uroporphyrinogen decarboxylase	ISS			PTHR21091:SF129	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00633	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MACMU|Ensembl=ENSMMUG00000004074|UniProtKB=F6ZJT0	Bone morphogenetic protein 7	ISS	9759503	PubMed	PTHR11848:SF135	BONE MORPHOGENETIC PROTEIN 7
P00010	B cell activation	P00402	Jnk	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00018	EGF receptor signaling pathway	P00545	JNK1-3	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00030	Hypoxia response via HIF activation	P00818	HIF-1alpha	MOUSE|MGI=MGI=106918|UniProtKB=Q61221	Hypoxia-inducible factor 1-alpha	TAS	14526383	PubMed	PTHR23043:SF7	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA
P00034	Integrin signalling pathway	P00951	Jnk	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	IDA	10851062	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04542	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PANTR|Ensembl=ENSPTRG00000002086|UniProtKB=H2Q1A9	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00056	VEGF signaling pathway	P01407	Erk	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00029	Huntington disease	P00803	Sp1	MOUSE|MGI=MGI=98372|UniProtKB=O89090	Transcription factor Sp1	RCA			PTHR23235:SF16	TRANSCRIPTION FACTOR SP1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00840	GPRK	BOVIN|Ensembl=ENSBTAG00000043994|UniProtKB=E1BP29	Protein-serine/threonine kinase	ISS	12032308	PubMed	PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P05913	Enkephalin release	P05974	G-Protein (i)	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	RAT|RGD=70958|UniProtKB=P19492	Glutamate receptor 3	ISS	12871085	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00059	p53 pathway	G01572	NOXA	HUMAN|HGNC=9108|UniProtKB=Q13794	Phorbol-12-myristate-13-acetate-induced protein 1	RCA			PTHR14299:SF0	PHORBOL-12-MYRISTATE-13-ACETATE-INDUCED PROTEIN 1
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P02785	Valine biosynthesis	P03216	Acetolactate synthase	STRCO|Gene=CAB37588|UniProtKB=Q9Z567	Acetolactate synthase	ISS			PTHR18968:SF116	ACETOLACTATE SYNTHASE ISOZYME 3 LARGE SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	CHICK|Ensembl=ENSGALG00000004796|UniProtKB=Q90694	Cell division control protein 42 homolog	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	HUMAN|HGNC=9299|UniProtKB=P67775	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05992	met-Enkephalin	RAT|RGD=68946|UniProtKB=P04094	Proenkephalin-A	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	DANRE|ZFIN=ZDB-GENE-051202-2|UniProtKB=Q6ZM67	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF3	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00221	JNK1	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00639	Shc	RAT|RGD=69348|UniProtKB=O70143	SHC-transforming protein 3	ISS	98175964	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	BACSU|EnsemblGenome=BSU20060|UniProtKB=O31875	Ribonucleoside-diphosphate reductase NrdEB subunit alpha	ISS			PTHR11573:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04651	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P06959	CCKR signaling map	P07088	RYR1/2/3	HUMAN|HGNC=10483|UniProtKB=P21817	Ryanodine receptor 1	RCA	21786193	PubMed	PTHR13715:SF15	RYANODINE RECEPTOR 1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00012	Cadherin signaling pathway	P00474	Wnt	PANTR|Ensembl=ENSPTRG00000001108|UniProtKB=H2PZP0	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	TAS	98269030	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05935	AngII	PANTR|Gene=AGT|UniProtKB=Q9GLN8	Angiotensinogen	ISS			PTHR11461:SF13	ANGIOTENSINOGEN
P00029	Huntington disease	P00807	Actin	CAEEL|WormBase=WBGene00000065|UniProtKB=P0DM42	Actin-3	IDA	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00014	Cholesterol biosynthesis	P00497	Anosterol synthase	RAT|RGD=620955|UniProtKB=P48450	Lanosterol synthase	ISS	P38604	SPACC	PTHR11764:SF20	LANOSTEROL SYNTHASE
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MOUSE|MGI=MGI=96276|UniProtKB=Q61224	5-hydroxytryptamine receptor 1D	ISS	12441358	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00034	Integrin signalling pathway	P00932	FAK	MACMU|Ensembl=ENSMMUG00000019159|UniProtKB=F6SS49	Uncharacterized protein	ISS	10753828	PubMed	PTHR24418:SF94	PROTEIN-TYROSINE KINASE 2-BETA
P02743	Formyltetrahydroformate biosynthesis	P02952	Methylene tetrahydrofolate dehydrogenase	MYCTU|EnsemblGenome=Rv3356c|UniProtKB=P9WG81	Bifunctional protein FolD	ISS			PTHR10025:SF46	BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00470	F-actin	DANRE|ZFIN=ZDB-GENE-030131-55|UniProtKB=Q6XNL8	Actin	IC	11889126	PubMed	PTHR11937:SF263	ACTIN
P00056	VEGF signaling pathway	P01425	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DICDI|dictyBase=DDB_G0268744|UniProtKB=Q55EU6	Putative actin-23	ISS	10974003	PubMed	PTHR11937:SF154	ACTIN-17-RELATED
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	RAT|RGD=1307535|UniProtKB=G3V928	Protein Lrp1	ISS	11907044	PubMed	PTHR44025:SF2	PROLOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	YEAST|SGD=S000000028|UniProtKB=P31109	Synaptobrevin homolog 1	IC			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00019	Endothelin signaling pathway	P00586	Gq	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00009	Axon guidance mediated by netrin	P00366	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	8649368	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00054	Toll receptor signaling pathway	P01364	TPL2	PANTR|Ensembl=ENSPTRG00000002400|UniProtKB=H2Q1S6	Mitogen-activated protein kinase kinase kinase 8	ISS	99133929	PubMed	PTHR24361:SF94	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 8
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00030	Hypoxia response via HIF activation	P00819	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=2652894|UniProtKB=Q80Y86	Mitogen-activated protein kinase 15	ISS	12787066	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	XENTR|Xenbase=XB-GENE-963560|UniProtKB=Q0VFC4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00539	14-3-3	XENTR|Xenbase=XB-GENE-970616|UniProtKB=Q6P4Z5	14-3-3 protein zeta	ISS	12615066	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00018	EGF receptor signaling pathway	P00552	Ras	PANTR|Ensembl=ENSPTRG00000003383|UniProtKB=H2Q376	Uncharacterized protein	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	IC	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00021	FGF signaling pathway	P00629	PP2A	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	88107662	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00051	TCA cycle	P01271	Fumarase	RAT|RGD=2614|UniProtKB=P14408	Fumarate hydratase, mitochondrial	ISS	227665	gi	PTHR11444:SF1	FUMARATE HYDRATASE, MITOCHONDRIAL
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00633	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00056	VEGF signaling pathway	P01403	VEGFR-2	BOVIN|Ensembl=ENSBTAG00000000782|UniProtKB=F1MWF1	Uncharacterized protein	ISS	11221852	PubMed	PTHR24416:SF45	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2
P02738	De novo purine biosynthesis	P02902	ADP reductase	ECOLI|EcoGene=EG12381|UniProtKB=P37146	Ribonucleoside-diphosphate reductase 2 subunit beta	ISS			PTHR23409:SF32	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT BETA
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00036	Interleukin signaling pathway	P00977	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	CHICK|Ensembl=ENSGALG00000004796|UniProtKB=Q90694	Cell division control protein 42 homolog	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00052	TGF-beta signaling pathway	P01286	TGFbeta	PANTR|Ensembl=ENSPTRG00000000578|UniProtKB=H2PYR2	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF173	BONE MORPHOGENETIC PROTEIN 8B
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02913	Thymidylate synthase	LEIMA|Gene=LmjF06.0860|UniProtKB=P07382	Bifunctional dihydrofolate reductase-thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P02728	Arginine biosynthesis	P02841	argininosuccinate lyase	BOVIN|Gene=ASL|UniProtKB=Q3SZJ0	Argininosuccinate lyase	ISS			PTHR43814:SF1	ARGININOSUCCINATE LYASE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00645	Rac	MONDO|Ensembl=ENSMODG00000003244|UniProtKB=F6THF0	Uncharacterized protein	ISS	97402517	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IDA	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00047	PDGF signaling pathway	P01172	c-Myc	DANRE|ZFIN=ZDB-GENE-040426-780|UniProtKB=Q7ZVS9	Transcriptional regulator Myc-B	ISS	9271375	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P02723	Adenine and hypoxanthine salvage pathway	P02809	Xanthine dehydrogenase	CAEBR|Gene=CBG21624|UniProtKB=A8Y084	Protein CBG21624	ISS			PTHR11908:SF100	XANTHINE DEHYDROGENASE
P06959	CCKR signaling map	P07055	SNAI1	HUMAN|HGNC=11128|UniProtKB=O95863	Zinc finger protein SNAI1	RCA	18515095	PubMed	PTHR44037:SF4	ZINC FINGER PROTEIN SNAI1
P00036	Interleukin signaling pathway	P00973	PKB	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00057	Wnt signaling pathway	P01451	Galpha	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00059	p53 pathway	P04623	CBP	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	IDA	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00018	EGF receptor signaling pathway	P00552	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00029	Huntington disease	P00785	Cytochrome c	PSEAE|EnsemblGenome=PA4429|UniProtKB=Q9HVY6	Probable cytochrome c1	IDA	15163634	PubMed	PTHR10266:SF4	SUBFAMILY NOT NAMED
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	PANTR|Ensembl=ENSPTRG00000018361|UniProtKB=P60020	5-hydroxytryptamine receptor 1B	ISS	11454663	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=1563132|UniProtKB=F1M7D0	Protein Pcdhb2	ISS	8120095	PubMed	PTHR24028:SF77	PROTOCADHERIN BETA-2
P02738	De novo purine biosynthesis	P02891	GDP kinase	DICDI|dictyBase=DDB_G0279911|UniProtKB=P34093	Nucleoside diphosphate kinase, mitochondrial	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04494	TSC2	CANLF|Ensembl=ENSCAFG00000019438|UniProtKB=F1Q054	Uncharacterized protein	ISS	12150915	PubMed	PTHR10063:SF0	TUBERIN
P02769	Purine metabolism	P03119	5'-Nucleotidase	PANTR|Ensembl=ENSPTRG00000018391|UniProtKB=H2QTC9	5'-nucleotidase, ecto (CD73)	ISS	3219501	gi	PTHR11575:SF25	5'-NUCLEOTIDASE
P00036	Interleukin signaling pathway	P00990	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01188	Gbetagamma	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00034	Integrin signalling pathway	P00938	Cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00015	Circadian clock system	G01497	cry	HUMAN|HGNC=2384|UniProtKB=Q16526	Cryptochrome-1	IDA	14507900	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	6264430	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00034	Integrin signalling pathway	P00942	Fyn	TAKRU|Ensembl=ENSTRUG00000003538|UniProtKB=H2S7D1	Tyrosine-protein kinase	ISS	9741627	PubMed	PTHR24418:SF242	TYROSINE-PROTEIN KINASE FYNB
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05972	PKA	DANRE|ZFIN=ZDB-GENE-040426-2427|UniProtKB=F1Q6C0	Uncharacterized protein (Fragment)	ISS	3037538	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00025	Hedgehog signaling pathway	P00682	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00059	p53 pathway	P04634	Cdc2	HUMAN|HGNC=1771|UniProtKB=P24941	Cyclin-dependent kinase 2	ISS	15660127	PubMed	PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P00049	Parkinson disease	P01230	Src kinase	MOUSE|MGI=MGI=88537|UniProtKB=P41241	Tyrosine-protein kinase CSK	IDA	11078745	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00056	VEGF signaling pathway	P01425	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	7492337	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00004	Alzheimer disease-presenilin pathway	P00114	actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g169611|UniProtKB=A7SEB1	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	9199552	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00018	EGF receptor signaling pathway	P00547	PP2A	MACMU|Ensembl=ENSMMUG00000004873|UniProtKB=F7ANY9	Uncharacterized protein	ISS	96161994	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P06587	Nicotine pharmacodynamics pathway	P06602	PPP1CA	DAPPU|EnsemblGenome=DAPPUDRAFT_231787|UniProtKB=E9HKA6	Serine/threonine-protein phosphatase	ISS	10433257	PubMed	PTHR11668:SF402	SERINE/THREONINE-PROTEIN PHOSPHATASE
P00045	Notch signaling pathway	P01101	Su(H)	PANTR|Ensembl=ENSPTRG00000015968|UniProtKB=H2R2Q6	Uncharacterized protein	ISS	15187023	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9060|UniProtKB=P51178	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	7822322	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P04393	Ras Pathway	P04542	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00047	PDGF signaling pathway	P01154	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	MOUSE|MGI=MGI=94926|UniProtKB=P51436	D(4) dopamine receptor	ISS	2039532	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_188187|UniProtKB=E9GJ31	Guanine nucleotide binding protein, q polypeptide	ISS	8836152	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00057	Wnt signaling pathway	P01451	Galpha	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	IDA	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00313	IKK	RAT|RGD=1306661|UniProtKB=G3V926	Conserved helix-loop-helix ubiquitous kinase (Predicted)	ISS	12813046	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00021	FGF signaling pathway	P00644	p38	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	PANTR|Ensembl=ENSPTRG00000004355|UniProtKB=H2Q4W8	Uncharacterized protein	ISS	6680790	gi	PTHR10489:SF618	C-X-C CHEMOKINE RECEPTOR TYPE 5
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01320	PLC-gamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MACMU|Ensembl=ENSMMUG00000002037|UniProtKB=F6WYF2	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF151	INTERSTITIAL COLLAGENASE
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01162	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00020	FAS signaling pathway	P00620	CytochromeC	IXOSC|EnsemblGenome=ISCW016731|UniProtKB=B7P8B3	Cytochrome c1, putative	ISS	15163634	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	TAS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=1749|UniProtKB=Q9Y6N8	Cadherin-10	IDA	8120095	PubMed	PTHR24027:SF290	CADHERIN-10
P00057	Wnt signaling pathway	P01451	Galpha	BOVIN|Ensembl=ENSBTAG00000019988|UniProtKB=F1N2V3	Uncharacterized protein	ISS	11359849	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	BOVIN|Ensembl=ENSBTAG00000040128|UniProtKB=F1MLJ8	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF23	FRIZZLED-4
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00628	JNK1-3	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04561	SRF	HUMAN|HGNC=11291|UniProtKB=P11831	Serum response factor	IDA	15170389	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00056	VEGF signaling pathway	P01409	cPLA2	CANLF|Ensembl=ENSCAFG00000013778|UniProtKB=F6UQ33	Phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00018	EGF receptor signaling pathway	P00565	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	ORNAN|Ensembl=ENSOANG00000006877|UniProtKB=F7CQF2	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00053	T cell activation	P01320	PLC-gamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P02749	Leucine biosynthesis	P03001	3-Isopropylmalate dehydrogenase	DEIRA|EnsemblGenome=DR_1785|UniProtKB=Q9RTH9	3-isopropylmalate dehydrogenase	ISS			PTHR42979:SF1	3-ISOPROPYLMALATE DEHYDROGENASE
P00006	Apoptosis signaling pathway	P00322	Cytochrome C	MACMU|Ensembl=ENSMMUG00000031713|UniProtKB=F7BU07	Uncharacterized protein	ISS	4954366	PubMed	PTHR11961:SF15	CYTOCHROME C
P00021	FGF signaling pathway	P00638	PLCgamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	EMENI|EnsemblGenome=CADANIAG00006296|UniProtKB=Q5ASG1	Putative synaptobrevin homologue SNC1/2 (Eurofung)	ISS			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00029	Huntington disease	P00790	beta-Tubulin	MACMU|Ensembl=ENSMMUG00000029059|UniProtKB=F6QAX2	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00059	p53 pathway	G04694	p110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00925	MEK	CANLF|Ensembl=ENSCAFG00000017851|UniProtKB=F1PBB6	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00053	T cell activation	P01331	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CHICK|Ensembl=ENSGALG00000028749|UniProtKB=Q5ZMQ2	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00005	Angiogenesis	P00203	Erk	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	9298898	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00641	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04393	Ras Pathway	P04552	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00057	Wnt signaling pathway	P01432	Beta-Catenin	CANLF|Ensembl=ENSCAFG00000005204|UniProtKB=B6V8E6	Catenin beta-1	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00047	PDGF signaling pathway	P01173	STAT	CANLF|Ensembl=ENSCAFG00000015509|UniProtKB=F1PNW8	Signal transducer and activator of transcription	ISS	22320921	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-961282|UniProtKB=Q6DF43	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00029	Huntington disease	P00777	CBP	CAEEL|WormBase=WBGene00009595|UniProtKB=Q7JMS5	Uncharacterized protein	IDA	8413673	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	MACMU|Ensembl=ENSMMUG00000011829|UniProtKB=F7H767	Uncharacterized protein	ISS			PTHR42884:SF8	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 6
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IGI	8787761	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00642	MEK1-2	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05913	Enkephalin release	P05972	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04393	Ras Pathway	P04552	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	8170357	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00019	Endothelin signaling pathway	P00589	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00475	Frizzled	MACMU|Ensembl=ENSMMUG00000022114|UniProtKB=F7H7V5	Uncharacterized protein	ISS	12549854	PubMed	PTHR11309:SF81	FRIZZLED-1
P04397	p53 pathway by glucose deprivation	P04640	p53	BOVIN|Ensembl=ENSBTAG00000001069|UniProtKB=P67939	Cellular tumor antigen p53	TAS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=98327|UniProtKB=P30873	Somatostatin receptor type 1	IDA	12562507	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P02785	Valine biosynthesis	P03216	Acetolactate synthase	SULSO|EnsemblGenome=SSO2774|UniProtKB=Q97V62	Acetolactate synthase large subunit homolog (IlvB-4)	ISS			PTHR18968:SF13	ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL
P00060	Ubiquitin proteasome pathway	P01491	E2	CANLF|Ensembl=ENSCAFG00000032353|UniProtKB=J9NTA2	Uncharacterized protein	ISS			PTHR24068:SF36	UBIQUITIN-CONJUGATING ENZYME E2 D1
P00053	T cell activation	P01336	Jnk	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00049	Parkinson disease	P01213	Cyclin E	PANTR|Ensembl=ENSPTRG00000010782|UniProtKB=H2R677	Cyclin E1	ISS	12628165	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00054	Toll receptor signaling pathway	P01345	IKKalpha	MACMU|Ensembl=ENSMMUG00000018476|UniProtKB=F6X938	Uncharacterized protein	ISS	12813046	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	MOUSE|MGI=MGI=109284|UniProtKB=Q61144	Presenilin-2	TAS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Ensembl=ENSPTRG00000000543|UniProtKB=H2PYN8	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00029	Huntington disease	P00780	Microtubule	BOVIN|Ensembl=ENSBTAG00000004093|UniProtKB=Q6B856	Tubulin beta-2B chain	ISS	12932731	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00021	FGF signaling pathway	P00632	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00057	Wnt signaling pathway	P01451	Galpha	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00060	Ubiquitin proteasome pathway	P01490	E3	MACMU|Ensembl=ENSMMUG00000006305|UniProtKB=F7HIU5	E3 ubiquitin-protein ligase	ISS			PTHR11254:SF299	NEDD4-LIKE E3 UBIQUITIN-PROTEIN LIGASE WWP1
P00039	Metabotropic glutamate receptor group III pathway	P01043	AC	MACMU|Ensembl=ENSMMUG00000010380|UniProtKB=F7D9M6	Uncharacterized protein	ISS	11744988	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P00048	PI3 kinase pathway	P01178	Grb2	DANRE|ZFIN=ZDB-GENE-040426-1975|UniProtKB=Q6PC73	Growth factor receptor-bound protein 2	ISS	8479536	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00018	EGF receptor signaling pathway	P00543	ERK1-2	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01194	S6K	BOVIN|Gene=RPS6KB1|UniProtKB=Q6TJY3	Ribosomal protein S6 kinase beta-1	ISS	15116068	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	MOUSE|MGI=MGI=88296|UniProtKB=O55017	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	8386525	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00029	Huntington disease	P00775	Rac	HUMAN|HGNC=672|UniProtKB=P84095	Rho-related GTP-binding protein RhoG	TAS	12932731	PubMed	PTHR24072:SF158	RHO-RELATED GTP-BINDING PROTEIN RHOG
P00053	T cell activation	P01312	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	ISS	8700226	PubMed	PTHR10048:SF14	PI-3 KINASE
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00023	General transcription regulation	P00667	TFIIFbeta	DROME|FlyBase=FBgn0010421|UniProtKB=P41900	General transcription factor IIF subunit 2	ISS			PTHR10445:SF0	GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MACMU|Ensembl=ENSMMUG00000022661|UniProtKB=F7GUA3	C-C chemokine receptor type 4	ISS	12009564	PubMed	PTHR10489:SF608	C-C CHEMOKINE RECEPTOR TYPE 4
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02723	Adenine and hypoxanthine salvage pathway	P02805	Adenine phosphorylase	THEMA|EnsemblGenome=TM_1737|UniProtKB=Q9X259	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00021	FGF signaling pathway	P00648	PKC	YEAST|SGD=S000000201|UniProtKB=P24583	Protein kinase C-like 1	IGI	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00021	FGF signaling pathway	P00629	PP2A	CANLF|Ensembl=ENSCAFG00000014257|UniProtKB=F1P8X1	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B	ISS	7918404	PubMed	PTHR11871:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B GAMMA ISOFORM
P00021	FGF signaling pathway	P00629	PP2A	HUMAN|HGNC=9300|UniProtKB=P62714	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	IDA	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	DAPPU|EnsemblGenome=DAPPUDRAFT_306746|UniProtKB=E9GYE9	Putative uncharacterized protein	ISS	4757952	gi	PTHR24072:SF192	CDC42 HOMOLOG
P00047	PDGF signaling pathway	P01160	IP3 receptor	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=12782|UniProtKB=P56703	Proto-oncogene Wnt-3	IDA	11266476	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P00029	Huntington disease	P00778	NMDA receptor	MOUSE|MGI=MGI=95821|UniProtKB=Q01097	Glutamate receptor ionotropic, NMDA 2B	IDA	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00021	FGF signaling pathway	P00629	PP2A	ANOGA|EnsemblGenome=AGAP004502|UniProtKB=Q7PQ61	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B	ISS			PTHR11871:SF0	PROTEIN PHOSPHATASE PP2A 55 KDA REGULATORY SUBUNIT
P00009	Axon guidance mediated by netrin	P00366	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00023	General transcription regulation	P00667	TFIIFbeta	BOVIN|Ensembl=ENSBTAG00000034495|UniProtKB=Q2T9L9	General transcription factor IIF subunit 2	ISS			PTHR10445:SF0	GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	PANTR|Ensembl=ENSPTRG00000006510|UniProtKB=H2Q8K1	Presenilin	ISS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P02785	Valine biosynthesis	P03215	Branched chain amino acid aminotransferase	PYRAE|EnsemblGenome=PAE3297|UniProtKB=Q8ZTE2	Branched-chain amino acid aminotransferase (IlvE)	ISS			PTHR42743:SF3	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE-LIKE PROTEIN 1-RELATED
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01332	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00034	Integrin signalling pathway	P00922	Collagen	RAT|RGD=61817|UniProtKB=P02454	Collagen alpha-1(I) chain	IDA	10778855	PubMed	PTHR24023:SF569	COLLAGEN ALPHA-1 I  CHAIN
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	RAT|RGD=628852|UniProtKB=Q02294	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	15079861	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00021	FGF signaling pathway	P00624	14-3-3	MONDO|Ensembl=ENSMODG00000013658|UniProtKB=F6TY10	Uncharacterized protein	ISS	22165492	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00054	Toll receptor signaling pathway	P01369	MKK1	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00047	PDGF signaling pathway	P01151	PKB	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01173	STAT	CANLF|Ensembl=ENSCAFG00000015509|UniProtKB=F1PNW8	Signal transducer and activator of transcription	ISS	96210005	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00029	Huntington disease	P00786	ARF	DROME|FlyBase=FBgn0039889|UniProtKB=H9XVM3	ADP ribosylation factor-like 4, isoform B	IPI			PTHR11711:SF186	ADP RIBOSYLATION FACTOR-LIKE 4, ISOFORM B
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT4G01370|UniProtKB=Q39024	Mitogen-activated protein kinase 4	ISS	11707292	PubMed	PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P00006	Apoptosis signaling pathway	P00318	PKCs	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00049	Parkinson disease	P01211	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00012	Cadherin signaling pathway	P00474	Wnt	MACMU|Ensembl=ENSMMUG00000006915|UniProtKB=F7EZ32	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00005	Angiogenesis	P00249	PAK	CANLF|Ensembl=ENSCAFG00000013067|UniProtKB=E2RJA0	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00045	Notch signaling pathway	P01113	Pen-2	DANRE|ZFIN=ZDB-GENE-000330-9|UniProtKB=Q90ZE4	Presenilin-2	IEP	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P04398	p53 pathway feedback loops 2	P04661	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	14526383	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P04393	Ras Pathway	P04546	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	IDA	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00034	Integrin signalling pathway	P00951	Jnk	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00020	FAS signaling pathway	P00620	CytochromeC	ORYSJ|EnsemblGenome=OS01G0935700|UniProtKB=Q942X6	Os01g0935700 protein	IGI	15163634	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P05730	Endogenous cannabinoid signaling	P05748	mGluR	PANTR|Ensembl=ENSPTRG00000018684|UniProtKB=C7G3M7	Glutamate receptor, metabotropic 1	ISS	7476890	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00029	Huntington disease	P00796	Kainate receptor	MOUSE|MGI=MGI=95818|UniProtKB=Q61626	Glutamate receptor ionotropic, kainate 5	IDA	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00053	T cell activation	P01319	PAK	MOUSE|MGI=MGI=1339975|UniProtKB=O88643	Serine/threonine-protein kinase PAK 1	IDA	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P02788	Xanthine and guanine salvage pathway	P03245	Guanine phosphoribosyl transferase	THEMA|EnsemblGenome=TM_0206|UniProtKB=Q9WY49	Hypoxanthine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02724	Alanine biosynthesis	P02815	Branched chain amino acid aminotransferase	ANOGA|EnsemblGenome=AGAP000011|UniProtKB=Q7QEI9	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF44	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00019	Endothelin signaling pathway	P00570	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MACMU|Gene=CCRL2|UniProtKB=Q9XSD7	C-C chemokine receptor-like 2	IC			PTHR10489:SF655	C-C CHEMOKINE RECEPTOR-LIKE 2
P00054	Toll receptor signaling pathway	P01352	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02728	Arginine biosynthesis	P02846	Ornithine carbamoyl transferase	RAT|RGD=3236|UniProtKB=P00481	Ornithine carbamoyltransferase, mitochondrial	ISS			PTHR11405:SF1	ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL
P02734	Chorismate biosynthesis	P02869	3-Dehydroquinate dehydratase	ECOLI|EcoGene=EG10076|UniProtKB=P05194	3-dehydroquinate dehydratase	ISS			PTHR43699:SF1	3-DEHYDROQUINATE DEHYDRATASE
P00059	p53 pathway	P01486	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	TAS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CAEEL|WormBase=WBGene00000042|UniProtKB=P48182	Acetylcholine receptor subunit beta-type acr-2	IC	22213672	PubMed	PTHR18945:SF744	ACETYLCHOLINE RECEPTOR SUBUNIT BETA-TYPE ACR-2
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00057	Wnt signaling pathway	P01438	PP2A	PANTR|Ensembl=ENSPTRG00000018180|UniProtKB=H2QT14	Protein phosphatase 2, regulatory subunit B', delta	ISS	10092233	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00034	Integrin signalling pathway	P00924	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00045	Notch signaling pathway	P01104	Serrate	MONDO|Ensembl=ENSMODG00000004910|UniProtKB=F7C1Q4	Delta-like protein	ISS	10551863	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04398	p53 pathway feedback loops 2	P04665	AKT	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	ISS	21291563	gi	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04556	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	12411479	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	PANTR|Ensembl=ENSPTRG00000012660|UniProtKB=H2QJ07	Activating transcription factor 2	ISS	11390664	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00018	EGF receptor signaling pathway	P00547	PP2A	DANRE|ZFIN=ZDB-GENE-050417-441|UniProtKB=Q567Y8	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00983	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00114	actin	HUMAN|HGNC=129|UniProtKB=P68133	Actin, alpha skeletal muscle	IDA	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	TAS	10851062	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00034	Integrin signalling pathway	P00922	Collagen	RAT|RGD=1595704|UniProtKB=A0A0G2K2Q8	Protein Col13a1	ISS	10778855	PubMed	PTHR44988:SF1	COLLAGEN ALPHA-1 XIII  CHAIN
P05730	Endogenous cannabinoid signaling	P05746	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05918	p38 MAPK pathway	P06021	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	TAS	14526383	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	CAEBR|Gene=CBG05056|UniProtKB=A8WZ27	Protein CBR-GLT-4	ISS	96032356	PubMed	PTHR11958:SF56	SODIUM-DEPENDENT EXCITATORY AMINO ACID TRANSPORTER GLT-4-RELATED
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00391	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02770	Pyridoxal phosphate salvage pathway	P03122	Pyridoxamine kinase	ANOGA|EnsemblGenome=AGAP005929|UniProtKB=Q7Q6C1	AGAP005929-PA	ISS			PTHR10534:SF2	PYRIDOXAL KINASE
P00021	FGF signaling pathway	P00642	MEK1-2	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01199	Galpha	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	IC	11554549	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00021	FGF signaling pathway	P00632	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00056	VEGF signaling pathway	P01407	Erk	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00059	p53 pathway	P01486	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02724	Alanine biosynthesis	P02815	Branched chain amino acid aminotransferase	RAT|RGD=68948|UniProtKB=O35854	Branched-chain-amino-acid aminotransferase, mitochondrial	ISS			PTHR11825:SF39	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, MITOCHONDRIAL
P00057	Wnt signaling pathway	P01438	PP2A	DANRE|ZFIN=ZDB-GENE-030904-7|UniProtKB=Q8AXX6	Ppp2r5e2 protein	ISS	11007767	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00018	EGF receptor signaling pathway	P00543	ERK1-2	DICDI|dictyBase=DDB_G0283903|UniProtKB=Q54QB1	Extracellular signal-regulated kinase 2	IGI			PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	BOVIN|Ensembl=ENSBTAG00000026306|UniProtKB=G3MXQ4	Uncharacterized protein	ISS			PTHR12264:SF21	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00016	Cytoskeletal regulation by Rho GTPase	P00514	MLCK	RAT|RGD=620934|UniProtKB=P20689	Myosin light chain kinase 2, skeletal/cardiac muscle	TAS	11157482	PubMed	PTHR45210:SF1	MYOSIN LIGHT CHAIN KINASE 2, SKELETAL/CARDIAC MUSCLE
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00009	Axon guidance mediated by netrin	P00366	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00053	T cell activation	P01331	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IDA	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00047	PDGF signaling pathway	P01167	Ets	MACMU|Ensembl=ENSMMUG00000020706|UniProtKB=F6PU72	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P02766	Phenylethylamine degradation	P03103	Phenylethylamine oxidase	PANTR|Ensembl=ENSPTRG00000019866|UniProtKB=H2R2M5	Amine oxidase	ISS			PTHR10638:SF3	AMILORIDE-SENSITIVE AMINE OXIDASE  COPPER-CONTAINING
P00056	VEGF signaling pathway	P01417	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00021	FGF signaling pathway	P00625	MKK3,6	CANLF|Ensembl=ENSCAFG00000018530|UniProtKB=F1PXD3	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	CAEEL|WormBase=WBGene00006779|UniProtKB=O62305	Calcium/calmodulin-dependent protein kinase type II	ISS	12888804	PubMed	PTHR43940:SF1	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	RAT|RGD=2738|UniProtKB=Q00960	Glutamate receptor ionotropic, NMDA 2B	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00005	Angiogenesis	P00249	PAK	MACMU|Ensembl=ENSMMUG00000001387|UniProtKB=F7D0B4	Uncharacterized protein	ISS	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00047	PDGF signaling pathway	P01151	PKB	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	12655147	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00371	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02723	Adenine and hypoxanthine salvage pathway	P02804	Hypoxanthine phosphoribosyl transferase	CAEEL|WormBase=WBGene00013690|UniProtKB=Q9NF11	Hypoxanthine PhosphoRibosylTransferase homolog	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00025	Hedgehog signaling pathway	P00692	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00029	Huntington disease	P00805	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IDA	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04542	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	ARATH|TAIR=AT2G43790|UniProtKB=Q39026	Mitogen-activated protein kinase 6	ISS			PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P00038	JAK/STAT signaling pathway	P01034	Jak	HUMAN|HGNC=6192|UniProtKB=O60674	Tyrosine-protein kinase JAK2	ISS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	TAKRU|Ensembl=ENSTRUG00000012143|UniProtKB=H2U1C0	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00020	FAS signaling pathway	P00615	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05915	Opioid proenkephalin pathway	P05988	peptide E	RAT|RGD=68946|UniProtKB=P04094	Proenkephalin-A	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00054	Toll receptor signaling pathway	P01375	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00034	Integrin signalling pathway	P00947	Laminin	RAT|RGD=1306311|UniProtKB=D3ZQN7	Protein Lamb1	ISS	2538453	PubMed	PTHR10574:SF233	LAMININ SUBUNIT BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00052	TGF-beta signaling pathway	P01275	P38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	TAS	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=109356|UniProtKB=O09044	Synaptosomal-associated protein 23	IC	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P06664	Gonadotropin-releasing hormone receptor pathway	P06715	Pcaf	MOUSE|MGI=MGI=1343094|UniProtKB=Q9JHD1	Histone acetyltransferase KAT2B	RCA	12724314	PubMed	PTHR22880:SF116	HISTONE ACETYLTRANSFERASE KAT2B
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	ARATH|TAIR=AT1G04950|UniProtKB=Q9MAU3	Transcription initiation factor TFIID subunit 6	ISS	2196466	gi	PTHR10221:SF13	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6
P00016	Cytoskeletal regulation by Rho GTPase	P00525	N-WASP	HUMAN|HGNC=12735|UniProtKB=O00401	Neural Wiskott-Aldrich syndrome protein	ISS	12932731	PubMed	PTHR23202:SF39	NEURAL WISKOTT-ALDRICH SYNDROME PROTEIN
P04398	p53 pathway feedback loops 2	P04665	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00008	Axon guidance mediated by Slit/Robo	P00342	Slit	MOUSE|MGI=MGI=1315205|UniProtKB=Q9R1B9	Slit homolog 2 protein	IDA	10432110	PubMed	PTHR24373:SF107	SLIT HOMOLOG 2 PROTEIN
P00036	Interleukin signaling pathway	P00976	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MOUSE|MGI=MGI=95819|UniProtKB=P35438	Glutamate receptor ionotropic, NMDA 1	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CHICK|Ensembl=ENSGALG00000011086|UniProtKB=P68139	Actin, alpha skeletal muscle	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	BOVIN|Ensembl=ENSBTAG00000008535|UniProtKB=E1BIS1	Uncharacterized protein	ISS	15032587	PubMed	PTHR45052:SF1	SUPPRESSOR OF CYTOKINE SIGNALING 7
P02746	Heme biosynthesis	P02982	Protoheme IX farnesyl transferase	HALSA|EnsemblGenome=VNG_0666G|UniProtKB=Q9HRJ8	Protoheme IX farnesyltransferase	ISS			PTHR43448:SF2	PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	TAKRU|Ensembl=ENSTRUG00000000584|UniProtKB=H2RMN2	Uncharacterized protein	IDA	11248120	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00017	DNA replication	P00530	Top	LEIMA|EnsemblGenome=LmjF.15.1290|UniProtKB=Q4QF53	DNA topoisomerase 2	ISS	11328867	PubMed	PTHR10169:SF50	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00981	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	TAS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00030	Hypoxia response via HIF activation	P00819	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00796	Kainate receptor	CHICK|Ensembl=ENSGALG00000002098|UniProtKB=F1P0L4	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DICDI|dictyBase=DDB_G0277143|UniProtKB=P36408	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MACMU|Ensembl=ENSMMUG00000009679|UniProtKB=F6YBQ8	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	IDA	4506785	gi	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00010	B cell activation	P00376	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	BOVIN|Ensembl=ENSBTAG00000001137|UniProtKB=P04973	Clathrin light chain A	IDA	11889126	PubMed	PTHR10639:SF1	CLATHRIN LIGHT CHAIN A
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00024	Glycolysis	P00674	Phosphoglucose isomerase	HUMAN|HGNC=4458|UniProtKB=P06744	Glucose-6-phosphate isomerase	RCA			PTHR11469:SF4	GLUCOSE-6-PHOSPHATE ISOMERASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000018202|UniProtKB=E2RPJ2	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=98961|UniProtKB=P24383	Protein Wnt-7a	IDA	8717036	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00038	JAK/STAT signaling pathway	P01027	STAT	XENTR|Xenbase=XB-GENE-5913743|UniProtKB=F6T2X3	Signal transducer and activator of transcription	ISS	11472851	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P02746	Heme biosynthesis	P02974	Uroporphyrinogen-III synthase	RAT|RGD=1310396|UniProtKB=Q5XIF2	Protein Uros	ISS			PTHR12390:SF0	UROPORPHYRINOGEN-III SYNTHASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IDA	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	ORNAN|Ensembl=ENSOANG00000015652|UniProtKB=F7FY70	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00047	PDGF signaling pathway	P01174	Rho	DROME|FlyBase=FBgn0036257|UniProtKB=Q9VTU3	Rho GTPase-activating protein 68F	ISS			PTHR23176:SF0	RHO GTPASE-ACTIVATING PROTEIN 68F
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04397	p53 pathway by glucose deprivation	P04644	TSC2	BOVIN|Ensembl=ENSBTAG00000020617|UniProtKB=E1BNT2	Uncharacterized protein	ISS	12150915	PubMed	PTHR10063:SF0	TUBERIN
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	MOUSE|MGI=MGI=109323|UniProtKB=Q02152	5-hydroxytryptamine receptor 2B	ISS	11859080	PubMed	PTHR24247:SF31	5-HYDROXYTRYPTAMINE RECEPTOR 2B
P00022	General transcription by RNA polymerase I	P00650	TAF-IB	HUMAN|HGNC=17300|UniProtKB=Q7Z7C8	Transcription initiation factor TFIID subunit 8	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00021	FGF signaling pathway	P00644	p38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00046	Oxidative stress response	P01135	p38	CAEEL|WormBase=WBGene00004055|UniProtKB=Q17446	Mitogen-activated protein kinase pmk-1	TAS	11707292	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00019	Endothelin signaling pathway	P00583	cPLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CANLF|Ensembl=ENSCAFG00000015708|UniProtKB=F2Z4N0	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05918	p38 MAPK pathway	P06035	TAB1	MACMU|Ensembl=ENSMMUG00000012103|UniProtKB=F7H8X1	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform alpha	ISS	8638164	PubMed	PTHR13832:SF533	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1
P00059	p53 pathway	P01486	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00790	beta-Tubulin	PANTR|Ensembl=ENSPTRG00000010369|UniProtKB=H2QF52	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF253	TUBULIN BETA-4A CHAIN
P05916	Opioid prodynorphin pathway	P06002	G-protein	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00775	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	TAS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	ARATH|TAIR=AT5G11520|UniProtKB=P46644	Aspartate aminotransferase 3, chloroplastic	ISS			PTHR11879:SF33	ASPARTATE AMINOTRANSFERASE 3, CHLOROPLASTIC
P00059	p53 pathway	P01486	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00778	NMDA receptor	MOUSE|MGI=MGI=1933206|UniProtKB=A2AIR5	Protein Grin3a	ISS	11554554	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P02781	Threonine biosynthesis	P03192	Aspartate semialdehyde dehydrogenase	ARATH|TAIR=AT1G14820|UniProtKB=B9DGS8	AT1G14820 protein	ISS			PTHR10174:SF121	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01178	Grb2	CAEBR|Gene=CBG16856|UniProtKB=A8XPY6	Protein CBR-SEM-5	ISS	4504111	gi	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P02775	Salvage pyrimidine ribonucleotides	P03155	Cytosine deaminase	DEIRA|EnsemblGenome=DR_1207|UniProtKB=Q9RV23	tRNA(Ile)-lysidine synthase	ISS			PTHR43033:SF1	TRNA ILE -LYSIDINE SYNTHASE
P00049	Parkinson disease	P01235	Fyn kinase	MOUSE|MGI=MGI=95602|UniProtKB=P39688	Tyrosine-protein kinase Fyn	IDA	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00021	FGF signaling pathway	P00633	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P04395	Vasopressin synthesis	P04594	Neurophysin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04543	MEKK1/4	RAT|RGD=1311192|UniProtKB=A0A0G2K3R1	Protein Map3k4	ISS	602425	OMIM	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P02753	Methionine biosynthesis	P03026	O-Succinyl homoserine lyase	SCHPO|PomBase=SPBC15D4.09c|UniProtKB=O74314	Probable cystathionine gamma-synthase	ISS			PTHR42699:SF1	CYSTATHIONINE GAMMA-SYNTHASE-RELATED
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00049	Parkinson disease	P01211	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00643	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00925	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00025	Hedgehog signaling pathway	P00682	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00475	Frizzled	MOUSE|MGI=MGI=1196625|UniProtKB=O70421	Frizzled-1	IDA	8717036	PubMed	PTHR11309:SF81	FRIZZLED-1
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00053	T cell activation	P01306	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00006	Apoptosis signaling pathway	P00269	MAPK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00039	Metabotropic glutamate receptor group III pathway	P01043	AC	MACMU|Ensembl=ENSMMUG00000010380|UniProtKB=F7D9M6	Uncharacterized protein	ISS	10915626	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P00059	p53 pathway	P04623	CBP	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00053	T cell activation	P01330	IKK	BOVIN|Ensembl=ENSBTAG00000007591|UniProtKB=Q95KV1	Inhibitor of nuclear factor kappa-B kinase subunit alpha	IGI	9346484	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	HUMAN|HGNC=23720|UniProtKB=Q70SY1	Cyclic AMP-responsive element-binding protein 3-like protein 2	RCA			PTHR22952:SF96	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00034	Integrin signalling pathway	P00942	Fyn	PANTR|Ensembl=ENSPTRG00000018511|UniProtKB=H2QTK7	Tyrosine-protein kinase	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00019	Endothelin signaling pathway	P00586	Gq	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000014571|UniProtKB=F7GRQ8	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF119	PROTOCADHERIN ALPHA-C2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DROME|FlyBase=FBgn0001122|UniProtKB=P16378	G protein alpha o subunit	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00019	Endothelin signaling pathway	P00566	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01188	Gbetagamma	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00056	VEGF signaling pathway	P01402	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	RCA			PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04398	p53 pathway feedback loops 2	P04664	cyclin E	PANTR|Ensembl=ENSPTRG00000010782|UniProtKB=H2R677	Cyclin E1	ISS	12729791	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P05730	Endogenous cannabinoid signaling	P05746	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05913	Enkephalin release	P05974	G-Protein (i)	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	IC	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=1100883|UniProtKB=O35161	Cadherin EGF LAG seven-pass G-type receptor 1	IDA	8120095	PubMed	PTHR24026:SF36	CADHERIN EGF LAG SEVEN-PASS G-TYPE RECEPTOR 1
P00018	EGF receptor signaling pathway	P00564	Rac	DICDI|dictyBase=DDB_G0282365|UniProtKB=P34146	Rho-related protein rac1C	IGI	12932731	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00047	PDGF signaling pathway	P01171	PLCgamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04371	5-Hydroxytryptamine biosynthesis	P04400	Aromatic L-amino acid decarboxylase	CAEEL|WormBase=WBGene00006562|UniProtKB=Q95ZS2	Tyrosine decarboxylase	ISS			PTHR11999:SF70	MIP05841P
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00048	PI3 kinase pathway	P01181	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04392	P53 pathway feedback loops 1	G04683	Cop-1	MACMU|Ensembl=ENSMMUG00000002072|UniProtKB=F6QR11	E3 ubiquitin-protein ligase RFWD2 isoform a	ISS	15103385	PubMed	PTHR44080:SF1	E3 UBIQUITIN-PROTEIN LIGASE RFWD2
P00018	EGF receptor signaling pathway	P00563	Gab	MACMU|Ensembl=ENSMMUG00000000828|UniProtKB=F6Q223	GRB2-associated-binding protein 1 isoform a	ISS	4503851	gi	PTHR12156:SF18	GRB2-ASSOCIATED-BINDING PROTEIN 1
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	CANLF|Gene=PSEN1|UniProtKB=Q6RH31	Presenilin-1	ISS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	RAT|RGD=2739|UniProtKB=Q00961	Glutamate receptor ionotropic, NMDA 2C	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CHICK|Ensembl=ENSGALG00000009844|UniProtKB=P68034	Actin, alpha cardiac muscle 1	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000014334|UniProtKB=F7CYY6	Uncharacterized protein	ISS	1319557	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IC	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00005	Angiogenesis	P00204	PLD	MOUSE|MGI=MGI=109585|UniProtKB=Q9Z280	Phospholipase D1	ISS	10497874	PubMed	PTHR18896:SF57	PHOSPHOLIPASE D1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=98958|UniProtKB=P22725	Protein Wnt-5a	IDA	11266476	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00050	Plasminogen activating cascade	P01249	pro-tPA	MACMU|Ensembl=ENSMMUG00000014432|UniProtKB=F7BHV7	Tissue-type plasminogen activator	ISS	6572897	PubMed	PTHR44617:SF1	TISSUE-TYPE PLASMINOGEN ACTIVATOR
P00053	T cell activation	P01318	PKC-theta	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00030	Hypoxia response via HIF activation	P00817	TOR	YEAST|SGD=S000003827|UniProtKB=P35169	Serine/threonine-protein kinase TOR1	ISS			PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00049	Parkinson disease	P01230	Src kinase	MACMU|Ensembl=ENSMMUG00000017017|UniProtKB=F7FVL2	Tyrosine-protein kinase	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DANRE|ZFIN=ZDB-GENE-000322-1|UniProtKB=Q9I8V1	Actin, alpha 1, skeletal muscle	IC	11889139	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	CANLF|Ensembl=ENSCAFG00000017522|UniProtKB=Q076A4	Myosin-8	ISS	89264452	PubMed	PTHR13140:SF368	MYOSIN-8
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00011	Blood coagulation	P00446	FVIIIa	CANLF|Gene=F8|UniProtKB=O18806	Coagulation factor VIII	ISS	2947308	gi	PTHR45309:SF1	COAGULATION FACTOR VIII
P00047	PDGF signaling pathway	P01153	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	DANRE|ZFIN=ZDB-GENE-000330-4|UniProtKB=Q1MTI1	Uncharacterized protein	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	LEIMA|EnsemblGenome=LmjF.04.1230|UniProtKB=Q9U1E8	Actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00023	General transcription regulation	P00670	TBP	ORYSJ|EnsemblGenome=OS01G0510800|UniProtKB=Q8LRG9	Os01g0510800 protein	ISS			PTHR10221:SF9	TAF6-LIKE RNA POLYMERASE II P300/CBP-ASSOCIATED FACTOR-ASSOCIATED FACTOR 65 KDA SUBUNIT 6L
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00627	ERK1-2	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00631	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12162872	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00018	EGF receptor signaling pathway	P00552	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	XENTR|Xenbase=XB-GENE-989949|UniProtKB=F6WGJ8	Uncharacterized protein	ISS	8143856	PubMed	PTHR24247:SF31	5-HYDROXYTRYPTAMINE RECEPTOR 2B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	MOUSE|MGI=MGI=87941|UniProtKB=Q3UYH7	Beta-adrenergic receptor kinase 2	ISS	10852916	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P00010	B cell activation	P00384	p38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IDA	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00049	Parkinson disease	P01211	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00049	Parkinson disease	P01230	Src kinase	MOUSE|MGI=MGI=96756|UniProtKB=P06240	Proto-oncogene tyrosine-protein kinase LCK	IDA	1505025	PubMed	PTHR24418:SF39	TYROSINE-PROTEIN KINASE LCK
P00047	PDGF signaling pathway	P01154	Ras	DICDI|dictyBase=DDB_G0283537|UniProtKB=P32254	Ras-like protein rasS	ISS	8290260	PubMed	PTHR24070:SF380	RAS-LIKE PROTEIN RASS
P00005	Angiogenesis	P00231	HSP27	CANLF|Ensembl=ENSCAFG00000014074|UniProtKB=E2RNB6	Uncharacterized protein	ISS			PTHR11527:SF37	ALPHA-CRYSTALLIN B CHAIN
P05915	Opioid proenkephalin pathway	P05994	G-protein	CRYNJ|EnsemblGenome=CND03830|UniProtKB=Q5KI86	Uncharacterized protein	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00057	Wnt signaling pathway	P01465	Ggamma	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00557	PI3K	NEUCR|EnsemblGenome=EFNCRG00000000622|UniProtKB=Q7SHZ6	Phosphoinositide 3-kinase	ISS			PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	IC	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-050417-59|UniProtKB=Q15KE4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IGI	12707323	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00056	VEGF signaling pathway	P01425	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	2837282	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P05731	GABA-B receptor II signaling	P05760	AC	RAT|RGD=2034|UniProtKB=P26770	Adenylate cyclase type 4	RCA	1946437	PubMed	PTHR11920:SF286	ADENYLATE CYCLASE TYPE 4
P00048	PI3 kinase pathway	P01188	Gbetagamma	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00053	T cell activation	P01318	PKC-theta	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	RAT|RGD=2740|UniProtKB=Q62645	Glutamate receptor ionotropic, NMDA 2D	ISS	11319238	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05913	Enkephalin release	P05972	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	176892	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04375	5HT3 type receptor mediated signaling pathway	P04425	K+ channel	CHICK|Ensembl=ENSGALG00000016193|UniProtKB=E1BYI0	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00009	Axon guidance mediated by netrin	P00360	DCC/UNC-40	CANLF|Ensembl=ENSCAFG00000000157|UniProtKB=F1PAZ4	Uncharacterized protein	ISS	12810718	PubMed	PTHR44146:SF3	NETRIN RECEPTOR DCC
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IC	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00057	Wnt signaling pathway	P01437	TCF	MONDO|Ensembl=ENSMODG00000015573|UniProtKB=F7AIP6	Uncharacterized protein (Fragment)	ISS	12356903	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00049	Parkinson disease	P01238	14-3-3	MOUSE|MGI=MGI=109194|UniProtKB=P68510	14-3-3 protein eta	IDA	14593000	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CAEEL|WormBase=WBGene00001187|UniProtKB=Q8MQA1	Uncharacterized protein	IC	8838325	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04393	Ras Pathway	P04542	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00057	Wnt signaling pathway	P01443	Phospholipase C	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00057	Wnt signaling pathway	P01451	Galpha	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05917	Opioid proopiomelanocortin pathway	P06009	K+ channel	BOVIN|Ensembl=ENSBTAG00000047488|UniProtKB=G3N1D1	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IDA	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00003	Alzheimer disease-amyloid secretase pathway	P00091	Aph-1	MOUSE|MGI=MGI=1915568|UniProtKB=Q9DCZ9	Putative gamma-secretase subunit APH-1C	IDA	12110170	PubMed	PTHR12889:SF1	GAMMA-SECRETASE SUBUNIT APH-1B
P00049	Parkinson disease	P01238	14-3-3	RAT|RGD=3980|UniProtKB=P63102	14-3-3 protein zeta/delta	ISS	92362864	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	RAT|RGD=2025|UniProtKB=P68136	Actin, alpha skeletal muscle	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CIOIN|Ensembl=ENSCING00000001377|UniProtKB=F6SDC9	Uncharacterized protein	ISS			PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00055	Transcription regulation by bZIP transcription factor	P01392	TFIIH complex	HUMAN|HGNC=4655|UniProtKB=P32780	General transcription factor IIH subunit 1	ISS			PTHR12856:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 1
P00005	Angiogenesis	P00251	cPLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00045	Notch signaling pathway	P01115	Neurotic	BOVIN|Gene=FUT8|UniProtKB=Q9N0W2	Alpha-(1,6)-fucosyltransferase	ISS			PTHR13132:SF29	ALPHA- 1,6 -FUCOSYLTRANSFERASE
P00019	Endothelin signaling pathway	P00587	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01211	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	20027584	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00047	PDGF signaling pathway	P01155	Jak	CANLF|Ensembl=ENSCAFG00000002102|UniProtKB=E2RPW6	Tyrosine-protein kinase	ISS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00025	Hedgehog signaling pathway	P00682	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	DANRE|ZFIN=ZDB-GENE-991119-4|UniProtKB=Q9W6T7	Presenilin-1	IDA	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00048	PI3 kinase pathway	P01177	P110ACT	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MACMU|Ensembl=ENSMMUG00000015705|UniProtKB=F6SM00	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00053	T cell activation	P01305	Calmodulin	MONDO|Ensembl=ENSMODG00000023174|UniProtKB=F7D7P2	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF197	CALMODULIN-LIKE PROTEIN 3
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01454	betaTrCP	MONDO|Ensembl=ENSMODG00000006464|UniProtKB=F7FGS3	Uncharacterized protein	ISS	12628165	PubMed	PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P00047	PDGF signaling pathway	P01152	RasGAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	ISS	8262392	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00047	PDGF signaling pathway	P01171	PLCgamma	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	TAS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00379	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00269	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05915	Opioid proenkephalin pathway	P05991	Enkephalin	PANTR|Ensembl=ENSPTRG00000020270|UniProtKB=H2QW70	Proenkephalin	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P06210	Activin beta signaling pathway	P06230	LACK	DROME|FlyBase=FBgn0029006|UniProtKB=Q9V853	E3 ubiquitin-protein ligase Smurf1	IEA	11252892	PubMed	PTHR11254:SF395	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P00047	PDGF signaling pathway	P01171	PLCgamma	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000004742|UniProtKB=H2Q5K1	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04393	Ras Pathway	P04558	p38	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	IDA	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00021	FGF signaling pathway	P00633	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	BOVIN|Ensembl=ENSBTAG00000013298|UniProtKB=A4IFJ5	Cytosolic phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000010393|UniProtKB=F7D992	Uncharacterized protein	ISS	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	IDA	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00021	FGF signaling pathway	P00638	PLCgamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00048	PI3 kinase pathway	P01190	PDK1 ACT	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	IDA	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00111	C99	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00034	Integrin signalling pathway	P00940	Src	PANTR|Ensembl=ENSPTRG00000013474|UniProtKB=H2QKB4	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=1306541|UniProtKB=D3ZVF3	Phosphoinositide-3-kinase, class 2, beta polypeptide (Predicted)	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00045	Notch signaling pathway	P01099	Notch	RAT|RGD=1303282|UniProtKB=Q6MG89	Notch homolog 4, [Drosophila]	ISS	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P00010	B cell activation	P00371	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00786	ARF	PANTR|Ensembl=ENSPTRG00000005350|UniProtKB=H2Q6P9	ADP-ribosylation factor-like 1	ISS	12932731	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P04395	Vasopressin synthesis	P04593	Glycopeptide	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MACMU|Ensembl=ENSMMUG00000005238|UniProtKB=F7BWT2	Uncharacterized protein	ISS	12181435	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	ORNAN|Ensembl=ENSOANG00000004342|UniProtKB=F6S3B9	Uncharacterized protein	ISS	12441358	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00223	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00009	Axon guidance mediated by netrin	P00361	Ena	CANLF|Gene=VASP|UniProtKB=P50551	Vasodilator-stimulated phosphoprotein	ISS			PTHR11202:SF12	VASODILATOR-STIMULATED PHOSPHOPROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	TAKRU|Ensembl=ENSTRUG00000002793|UniProtKB=H2S271	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF676	MYOSIN, HEAVY POLYPEPTIDE 2, FAST MUSCLE SPECIFIC
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	ISS	15621031	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05730	Endogenous cannabinoid signaling	P05751	Galpha	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT3G45640|UniProtKB=Q39023	Mitogen-activated protein kinase 3	ISS	10851062	PubMed	PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00019	Endothelin signaling pathway	P00590	IP3 R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	XENTR|Xenbase=XB-GENE-963560|UniProtKB=Q0VFC4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00021	FGF signaling pathway	P00645	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	RCA	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ORNAN|Ensembl=ENSOANG00000007581|UniProtKB=F6QWB7	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	MACMU|Ensembl=ENSMMUG00000011442|UniProtKB=F7B9T3	Ras-related protein Rap-1b	ISS	1904317	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	CAEEL|WormBase=WBGene00004259|UniProtKB=Q18990	PYRimidine biosynthesis	ISS			PTHR11405:SF5	CAD PROTEIN
P00047	PDGF signaling pathway	P01171	PLCgamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00053	T cell activation	P01324	rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00006	Apoptosis signaling pathway	P00269	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00052	TGF-beta signaling pathway	P01286	TGFbeta	HUMAN|HGNC=6067|UniProtKB=P09529	Inhibin beta B chain	TAS	11451570	PubMed	PTHR11848:SF29	INHIBIN BETA B CHAIN
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12805548	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01435	SWI/SNF	MONDO|Ensembl=ENSMODG00000014380|UniProtKB=F6T7C8	Uncharacterized protein	ISS	11532957	PubMed	PTHR12656:SF12	AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 1A
P00018	EGF receptor signaling pathway	P00552	Ras	DICPU|Gene=DICPUDRAFT_57324|UniProtKB=F0ZVH9	Putative uncharacterized protein rasS	ISS	8290260	PubMed	PTHR24070:SF380	RAS-LIKE PROTEIN RASS
P00029	Huntington disease	P00779	TBP	ANOGA|EnsemblGenome=AGAP010958|UniProtKB=Q7PFI3	AGAP010958-PA	IPI	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00021	FGF signaling pathway	P00640	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IGI	96009592	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00084	X11alpha	PANTR|Ensembl=ENSPTRG00000006842|UniProtKB=H2Q921	Uncharacterized protein	ISS	9614075	PubMed	PTHR12345:SF12	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 2
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00049	Parkinson disease	P01242	Casein kinase I	ARATH|TAIR=AT4G28880|UniProtKB=Q93Z18	Protein CASEIN KINASE I-LIKE 3	IDA	11437445	PubMed	PTHR11909:SF97	PROTEIN CASEIN KINASE I-LIKE 3-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P02749	Leucine biosynthesis	P03000	Branched chain amino acid aminotransferase	ARATH|TAIR=AT3G49680|UniProtKB=Q9M401	Branched-chain-amino-acid aminotransferase 3, chloroplastic	ISS			PTHR42825:SF2	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 3, CHLOROPLASTIC
P00010	B cell activation	P00371	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00644	p38	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	IGI	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	IC	15860573	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00029	Huntington disease	P00778	NMDA receptor	CANLF|Gene=GRIN1|UniProtKB=Q5R1P0	Glutamate receptor ionotropic, NMDA 1	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00053	T cell activation	P01332	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IDA	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IPI	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04393	Ras Pathway	P04559	Rac	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS	12874273	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00049	Parkinson disease	P01212	p38 MAPK	DROME|FlyBase=FBgn0024846|UniProtKB=O61443	Mitogen-activated protein kinase 14B	NAS	11274345	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00007	Axon guidance mediated by semaphorins	P00331	PAK	RAT|RGD=3250|UniProtKB=P35465	Serine/threonine-protein kinase PAK 1	ISS	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04395	Vasopressin synthesis	P04597	Signal Peptide	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00029	Huntington disease	P00786	ARF	CHICK|Ensembl=ENSGALG00000005622|UniProtKB=F1NGS7	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF110	ADP-RIBOSYLATION FACTOR 4
P00036	Interleukin signaling pathway	P00965	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	PANTR|Ensembl=ENSPTRG00000018075|UniProtKB=H2QSV3	TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa	ISS			PTHR13218:SF16	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11
P00019	Endothelin signaling pathway	P00591	PLCbeta	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00053	T cell activation	P01312	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00547	PP2A	ORYSJ|EnsemblGenome=OS01G0691700|UniProtKB=Q8RZZ3	Serine/threonine-protein phosphatase	ISS			PTHR11668:SF24	SERINE/THREONINE-PROTEIN PHOSPHATASE 6 CATALYTIC SUBUNIT
P00029	Huntington disease	P00774	Dynein complex	DROME|FlyBase=FBgn0267432|UniProtKB=A8Y5B7	Male fertility factor kl3	IPI	9454836	PubMed	PTHR10676:SF318	MALE FERTILITY FACTOR KL3
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	ORYSJ|EnsemblGenome=OS03G0747800|UniProtKB=Q9XEA8	Cysteine synthase	ISS			PTHR10314:SF157	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00054	Toll receptor signaling pathway	G01550	Gene trancription	PANTR|Ensembl=ENSPTRG00000001786|UniProtKB=H2Q0S9	Prostaglandin-endoperoxide synthase 2 (Prostaglandin G/H synthase and cyclooxygenase)	ISS	12871860	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P00005	Angiogenesis	P00211	GSK3beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	CANLF|Ensembl=ENSCAFG00000009967|UniProtKB=F1PGZ2	Muscarinic acetylcholine receptor	ISS	8100450	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	TAS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04392	P53 pathway feedback loops 1	P04539	p53	DANRE|ZFIN=ZDB-GENE-030819-1|UniProtKB=E9QG65	Uncharacterized protein	TAS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P02721	ATP synthesis	P02798	Cyt C	ORYSJ|EnsemblGenome=OS05G0420600|UniProtKB=Q0DI31	Cytochrome c	ISS	1646373	PubMed	PTHR11961:SF9	CYTOCHROME C-1-RELATED
P00057	Wnt signaling pathway	P01464	Pygo	MOUSE|MGI=MGI=1916161|UniProtKB=Q80V76	Protein Pygo2	ISS	11955446	PubMed	PTHR23194:SF7	PYGOPUS HOMOLOG 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00012	Cadherin signaling pathway	P00474	Wnt	TAKRU|Ensembl=ENSTRUG00000017138|UniProtKB=H2V3X9	Protein Wnt	IDA	8717036	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	RAT|RGD=1304559|UniProtKB=D4A3W9	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P04393	Ras Pathway	P04556	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	HUMAN|HGNC=4587|UniProtKB=Q14957	Glutamate receptor ionotropic, NMDA 2C	IC	11319238	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00021	FGF signaling pathway	P00644	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MOUSE|MGI=MGI=88398|UniProtKB=Q9ERZ3	Muscarinic acetylcholine receptor M3	IDA	12915051	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00049	Parkinson disease	P01219	SAPK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	NAS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	CHICK|Ensembl=ENSGALG00000007871|UniProtKB=F1NL65	Uncharacterized protein	ISS	96032356	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	TAKRU|Ensembl=ENSTRUG00000015213|UniProtKB=H2UPJ1	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF356	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00916	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	P01443	Phospholipase C	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00046	Oxidative stress response	P01135	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	TAS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04393	Ras Pathway	P04567	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01234	GRK	CANLF|Ensembl=ENSCAFG00000011733|UniProtKB=E2R5J6	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00021	FGF signaling pathway	P00632	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00049	Parkinson disease	P01227	20S proteasome	CAEBR|Gene=CBG02261|UniProtKB=A8WS54	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF14	PROTEASOME SUBUNIT ALPHA TYPE-5
P00029	Huntington disease	P00778	NMDA receptor	MACMU|Ensembl=ENSMMUG00000019112|UniProtKB=F6T8S6	N-methyl D-aspartate receptor subtype 2B	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	MACMU|Ensembl=ENSMMUG00000019112|UniProtKB=F6T8S6	N-methyl D-aspartate receptor subtype 2B	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	EMENI|EnsemblGenome=CADANIAG00004514|UniProtKB=Q96V52	Glutamine synthetase	ISS			PTHR20852:SF57	GLUTAMINE SYNTHETASE 2 CYTOPLASMIC
P00047	PDGF signaling pathway	P01171	PLCgamma	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	MACMU|Ensembl=ENSMMUG00000014627|UniProtKB=F7GNE4	Catenin beta-1	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MACMU|Ensembl=ENSMMUG00000004489|UniProtKB=F7GG37	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF137	NEUTROPHIL COLLAGENASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01311	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00057	Wnt signaling pathway	P01448	CBP	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00035	Interferon-gamma signaling pathway	P00961	STAT1	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00035	Interferon-gamma signaling pathway	P00960	PTP	BOVIN|Ensembl=ENSBTAG00000002048|UniProtKB=F1N339	Tyrosine-protein phosphatase non-receptor type	ISS	7681589	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	RCA	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02763	Peptidoglycan biosynthesis	P03087	Glutamate racemase	GLOVI|EnsemblGenome=BAC89437|UniProtKB=Q7NKI2	Glutamate racemase	ISS			PTHR21198:SF2	GLUTAMATE RACEMASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	IXOSC|EnsemblGenome=ISCW009711|UniProtKB=B7Q3T6	THO complex subunit, putative	ISS	9740024	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04395	Vasopressin synthesis	P04592	Exopeptidase	MACMU|Ensembl=ENSMMUG00000023400|UniProtKB=F7FE30	Carboxypeptidase E preproprotein	ISS	1778303	PubMed	PTHR11532:SF59	CARBOXYPEPTIDASE E
P00059	p53 pathway	P01480	PTEN	CAEEL|WormBase=WBGene00000913|UniProtKB=G5EE01	DAF-18	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MONDO|Ensembl=ENSMODG00000013079|UniProtKB=F7FB74	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00852	PYK2	CANLF|Ensembl=ENSCAFG00000008670|UniProtKB=E2QTG4	Uncharacterized protein	ISS	10753828	PubMed	PTHR24418:SF94	PROTEIN-TYROSINE KINASE 2-BETA
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	HUMAN|HGNC=6695|UniProtKB=O75074	Low-density lipoprotein receptor-related protein 3	IDA	11907044	PubMed	PTHR44062:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BOVIN|Ensembl=ENSBTAG00000005714|UniProtKB=Q3ZC07	Actin, alpha cardiac muscle 1	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00048	PI3 kinase pathway	P01188	Gbetagamma	DROME|FlyBase=FBgn0030011|UniProtKB=Q9W3J1	Gbeta5	IC	9754712	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	TAS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	SCHPO|PomBase=SPAC8C9.03|UniProtKB=P36600	cAMP-dependent protein kinase regulatory subunit	IC	88234494	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	TAS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00049	Parkinson disease	P01238	14-3-3	SCHMA|EnsemblGenome=Smp_034840|UniProtKB=G4V8A9	14-3-3 epsilon	IDA	21099905	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P02743	Formyltetrahydroformate biosynthesis	P02954	Thymidylate synthase	ECOLI|EcoGene=EG11002|UniProtKB=P0A884	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	RCA	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04393	Ras Pathway	P04541	p90RSK	HUMAN|HGNC=10430|UniProtKB=Q15418	Ribosomal protein S6 kinase alpha-1	ISS	2779569	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MACMU|Ensembl=ENSMMUG00000009679|UniProtKB=F6YBQ8	Uncharacterized protein	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00029	Huntington disease	P00790	beta-Tubulin	BOVIN|Ensembl=ENSBTAG00000023730|UniProtKB=Q2T9S0	Tubulin beta-3 chain	ISS	12932731	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P06664	Gonadotropin-releasing hormone receptor pathway	P06825	IRS-1	MOUSE|MGI=MGI=99454|UniProtKB=P35569	Insulin receptor substrate 1	RCA	5031805	gi	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00021	FGF signaling pathway	P00638	PLCgamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	11204774	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00053	T cell activation	P01306	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00004	Alzheimer disease-presenilin pathway	P00114	actin	YEAST|SGD=S000001855|UniProtKB=P60010	Actin	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02746	Heme biosynthesis	P02982	Protoheme IX farnesyl transferase	PSEAE|EnsemblGenome=PA0113|UniProtKB=Q9I719	Protoheme IX farnesyltransferase 1	ISS			PTHR43448:SF2	PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL
P06959	CCKR signaling map	P07137	VMAT2	HUMAN|HGNC=10935|UniProtKB=Q05940	Synaptic vesicular amine transporter	RCA	11459816	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00057	Wnt signaling pathway	P01451	Galpha	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00010	B cell activation	P00402	Jnk	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IDA	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00045	Notch signaling pathway	P01119	NIct	MACMU|Ensembl=ENSMMUG00000018375|UniProtKB=F7H1D5	Neurogenic locus notch homolog protein 2 isoform 1 preproprotein	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00310	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	RAT|RGD=1563860|UniProtKB=D3Z8E0	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00034	Integrin signalling pathway	P00924	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IPI	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IC	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00056	VEGF signaling pathway	P01417	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00218	STAT1	HUMAN|HGNC=11362|UniProtKB=P42224	Signal transducer and activator of transcription 1-alpha/beta	IDA	15825084	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00036	Interleukin signaling pathway	P00996	STAT	CANLF|Ensembl=ENSCAFG00000015509|UniProtKB=F1PNW8	Signal transducer and activator of transcription	ISS	96210005	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=1344366|UniProtKB=E9Q9Q6	Protein Cdh18	ISS	8120095	PubMed	PTHR24027:SF106	CADHERIN-18
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DROME|FlyBase=FBgn0000045|UniProtKB=P02574	Actin, larval muscle	IC	14684598	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00046	Oxidative stress response	P01131	MKP5	MOUSE|MGI=MGI=2387107|UniProtKB=Q7TNL7	Dual specificity phosphatase 9	TAS			PTHR10159:SF388	DUAL SPECIFICITY PROTEIN PHOSPHATASE 9
P02772	Pyruvate metabolism	P03137	Citrate Lyase	HUMAN|HGNC=115|UniProtKB=P53396	ATP-citrate synthase	IDA			PTHR23118:SF0	ATP-CITRATE SYNTHASE
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	TAS			PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00774	Dynein complex	DROME|FlyBase=FBgn0011760|UniProtKB=Q24117	Dynein light chain 1, cytoplasmic	IPI	9454836	PubMed	PTHR11886:SF62	DYNEIN, LIGHT CHAIN, LC8-TYPE 2
P02736	Coenzyme A biosynthesis	P02885	Pantothenate kinase	SCHPO|PomBase=SPBC4B4.01c|UniProtKB=O74962	Pantothenate kinase	ISS			PTHR12280:SF20	PANTOTHENATE KINASE 4
P00047	PDGF signaling pathway	P01154	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	HUMAN|HGNC=7174|UniProtKB=P09237	Matrilysin	IEP	12356903	PubMed	PTHR10201:SF143	MATRILYSIN
P00018	EGF receptor signaling pathway	P00543	ERK1-2	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00983	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	HUMAN|HGNC=9192|UniProtKB=P19388	DNA-directed RNA polymerases I, II, and III subunit RPABC1	ISS	11313498	gi	PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P00006	Apoptosis signaling pathway	P00260	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00059	p53 pathway	P04623	CBP	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00021	FGF signaling pathway	P00629	PP2A	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P01480	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00005	Angiogenesis	P00234	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12186904	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	6264430	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	METAC|EnsemblGenome=MA_3520|UniProtKB=Q8TK94	Serine hydroxymethyltransferase	ISS			PTHR11680:SF21	SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC
P00056	VEGF signaling pathway	P01409	cPLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00018	EGF receptor signaling pathway	P00542	EGFR	PANTR|Ensembl=ENSPTRG00000009100|UniProtKB=H2QCV1	Receptor protein-tyrosine kinase	ISS	4758298	gi	PTHR24416:SF137	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2
P00018	EGF receptor signaling pathway	P00558	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IGI	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04395	Vasopressin synthesis	P04594	Neurophysin	BOVIN|Ensembl=ENSBTAG00000008026|UniProtKB=P01175	Oxytocin-neurophysin 1	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00221	JNK1	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00049	Parkinson disease	P01238	14-3-3	CHICK|Gene_ORFName=RCJMB04_5e12|UniProtKB=Q5F3W6	14-3-3 protein gamma	ISS	1317796	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	MOUSE|MGI=MGI=103034|UniProtKB=P52633	Signal transducer and transcription activator 6	TAS	12039028	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00059	p53 pathway	P04609	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00896	Insulin IGF	RAT|RGD=2870|UniProtKB=P01346	Insulin-like growth factor II	ISS	4504609	gi	PTHR11454:SF10	INSULIN-LIKE GROWTH FACTOR II
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	RAT|RGD=2246|UniProtKB=Q07652	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	11976940	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P04380	Cortocotropin releasing factor receptor signaling pathway	P04453	ACTH	MONDO|Ensembl=ENSMODG00000015853|UniProtKB=Q95J84	Proopiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00018	EGF receptor signaling pathway	P00554	Shc	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	ISS	95096035	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04393	Ras Pathway	P04578	Rho	XENTR|Xenbase=XB-GENE-941426|UniProtKB=Q28HZ4	Novel Rho protein	ISS	11360179	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CANAL|CGD=CAL0064759|UniProtKB=Q5AKX0	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02788	Xanthine and guanine salvage pathway	P03247	Xanthine phosphoribosyl transferase	LEIMA|EnsemblGenome=LmjF.21.0845|UniProtKB=Q4QCC3	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	XENTR|Xenbase=XB-GENE-956713|UniProtKB=Q5XGD8	Guanine nucleotide binding protein, beta 3	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00009	Axon guidance mediated by netrin	P00363	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04393	Ras Pathway	P04552	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IDA	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	IXOSC|EnsemblGenome=ISCW003614|UniProtKB=B7PHY7	Cdc42 protein, putative	ISS	12932731	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00047	PDGF signaling pathway	P01142	p90RSK	PANTR|Ensembl=ENSPTRG00000000387|UniProtKB=H2PYE3	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00034	Integrin signalling pathway	P00924	Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	IPI	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00034	Integrin signalling pathway	P00924	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00059	p53 pathway	P04623	CBP	PANTR|Ensembl=ENSPTRG00000014418|UniProtKB=H2QLS0	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00012	Cadherin signaling pathway	P00466	EGFR	MOUSE|MGI=MGI=104771|UniProtKB=Q61527	Receptor tyrosine-protein kinase erbB-4	ISS	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00010	B cell activation	P00391	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00035	Interferon-gamma signaling pathway	P00961	STAT1	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	12191995	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00059	p53 pathway	P04630	PP2A	DANRE|ZFIN=ZDB-GENE-050417-441|UniProtKB=Q567Y8	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04452	proopiomelanocortin	MOUSE|MGI=MGI=97742|UniProtKB=P01193	Pro-opiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00056	VEGF signaling pathway	P01408	Akt/PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05918	p38 MAPK pathway	P06043	ASK1	MACMU|Ensembl=ENSMMUG00000016376|UniProtKB=F7G2W1	Uncharacterized protein	ISS	12566458	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00036	Interleukin signaling pathway	P00964	p90RSK	MACMU|Ensembl=ENSMMUG00000002134|UniProtKB=F6UNV6	Ribosomal protein S6 kinase	ISS	2779569	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00025	Hedgehog signaling pathway	P00682	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	IDA	88234494	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00029	Huntington disease	P00788	Calpain	RAT|RGD=1304855|UniProtKB=Q499T5	Calpain 7	ISS	11675509	PubMed	PTHR10183:SF22	CALPAIN-7
P00005	Angiogenesis	P00249	PAK	CANLF|Ensembl=ENSCAFG00000004956|UniProtKB=E2REH3	Uncharacterized protein	ISS	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CANLF|Ensembl=ENSCAFG00000013148|UniProtKB=Q5R1P3	Glutamate receptor ionotropic, NMDA 2B	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00996	STAT	CANLF|Ensembl=ENSCAFG00000015509|UniProtKB=F1PNW8	Signal transducer and activator of transcription	ISS	22320921	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00029	Huntington disease	P00811	Arp2/3 complex	CANLF|Ensembl=ENSCAFG00000015081|UniProtKB=E2RMT4	Uncharacterized protein	ISS	9618202	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00006	Apoptosis signaling pathway	P00318	PKCs	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05918	p38 MAPK pathway	P06031	p38alpha	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	RCA	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000016815|UniProtKB=F7C9S6	Uncharacterized protein	ISS	12181435	PubMed	PTHR24229:SF52	SOMATOSTATIN RECEPTOR TYPE 4
P00045	Notch signaling pathway	P01119	NIct	HUMAN|HGNC=7881|UniProtKB=P46531	Neurogenic locus notch homolog protein 1	IGI	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00057	Wnt signaling pathway	P01465	Ggamma	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00049	Parkinson disease	P01238	14-3-3	XENTR|Xenbase=XB-GENE-970616|UniProtKB=Q6P4Z5	14-3-3 protein zeta	ISS	12865427	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	PANTR|Ensembl=ENSPTRG00000009554|UniProtKB=H2QDP9	Uncharacterized protein	ISS	9554852	PubMed	PTHR10845:SF103	AXIN-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	DANRE|ZFIN=ZDB-GENE-030729-1|UniProtKB=B3DGN0	Opioid receptor, kappa 1	IDA	11259498	PubMed	PTHR24229:SF1	KAPPA-TYPE OPIOID RECEPTOR
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MACMU|Ensembl=ENSMMUG00000007027|UniProtKB=F7F210	Alpha-cardiac actin	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00045	Notch signaling pathway	P01114	Ntm	MOUSE|MGI=MGI=97364|UniProtKB=O35516	Neurogenic locus notch homolog protein 2	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00048	PI3 kinase pathway	P01177	P110ACT	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	MOUSE|MGI=MGI=88259|UniProtKB=Q923T9	Calcium/calmodulin-dependent protein kinase type II subunit gamma	ISS	12888804	PubMed	PTHR43940:SF7	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT GAMMA
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	MOUSE|MGI=MGI=1916120|UniProtKB=Q32M07	Adenylate kinase 8	ISS			PTHR23359:SF102	ADENYLATE KINASE 8
P04398	p53 pathway feedback loops 2	P04653	cdk2	BOVIN|Ensembl=ENSBTAG00000004021|UniProtKB=Q5E9Y0	Cyclin-dependent kinase 2	ISS	15660127	PubMed	PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9441|UniProtKB=P51817	cAMP-dependent protein kinase catalytic subunit PRKX	IC	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00015	Circadian clock system	G01497	cry	RAT|RGD=620935|UniProtKB=Q923I8	Cryptochrome-2	IDA	10428031	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04570	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ENTHI|EnsemblGenome=EHI_107290|UniProtKB=B1N2P0	Actin	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00005	Angiogenesis	P00219	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	RAT|RGD=61801|UniProtKB=P30994	5-hydroxytryptamine receptor 2B	IDA			PTHR24247:SF31	5-HYDROXYTRYPTAMINE RECEPTOR 2B
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00048	PI3 kinase pathway	P01190	PDK1 ACT	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	IGI	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00029	Huntington disease	P00807	Actin	CANLF|Ensembl=ENSCAFG00000003197|UniProtKB=E2QXY7	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	RAT|RGD=71009|UniProtKB=P21932	Adenylate cyclase type 3	IDA	2491850	PubMed	PTHR11920:SF291	ADENYLATE CYCLASE TYPE 3
P00047	PDGF signaling pathway	P01146	Ikk	MACMU|Ensembl=ENSMMUG00000008351|UniProtKB=F7HRV5	Inhibitor of nuclear factor kappa-B kinase subunit beta	RCA			PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00029	Huntington disease	P00786	ARF	ARATH|TAIR=AT1G02440|UniProtKB=F4HXI5	ADP-ribosylation factor D1A	IPI	12932731	PubMed	PTHR11711:SF210	ADP-RIBOSYLATION FACTOR 2-A-RELATED
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00036	Interleukin signaling pathway	P00976	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	7667318	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02759	Pyridoxal-5-phosphate biosynthesis	P03058	Phosphohydroxythreonine aminotransferase	MOUSE|MGI=MGI=2183441|UniProtKB=Q99K85	Phosphoserine aminotransferase	ISS	20886743	gi	PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DICDI|dictyBase=DDB_G0289811|UniProtKB=Q54GX7	Actin-10	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	MOUSE|MGI=MGI=96558|UniProtKB=P21183	Interleukin-5 receptor subunit alpha	IPI	2265612	PubMed	PTHR23036:SF17	INTERLEUKIN-5 RECEPTOR SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	DANRE|ZFIN=ZDB-GENE-990415-279|UniProtKB=P51029	Protein Wnt-8b	TAS	8717036	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000013047|UniProtKB=E1BLE8	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00048	PI3 kinase pathway	P01179	PKB	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00057	Wnt signaling pathway	P01444	Wnt	DANRE|ZFIN=ZDB-GENE-980526-416|UniProtKB=Q92048	Protein Wnt-2	IDA	11266476	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00236	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	TAS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00249	PAK	HUMAN|HGNC=8591|UniProtKB=Q13177	Serine/threonine-protein kinase PAK 2	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P02753	Methionine biosynthesis	P03026	O-Succinyl homoserine lyase	ORYSJ|EnsemblGenome=OS10G0399200|UniProtKB=Q94I44	Cys/Met metabolism PLP-dependent enzyme family protein	ISS			PTHR43379:SF3	SUBFAMILY NOT NAMED
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	CANLF|Ensembl=ENSCAFG00000001622|UniProtKB=E2RN76	Uncharacterized protein	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00048	PI3 kinase pathway	P01177	P110ACT	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00973	PKB	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00958	PIAS	MOUSE|MGI=MGI=1913126|UniProtKB=O54714	E3 SUMO-protein ligase PIAS3	TAS	8682149	PubMed	PTHR10782:SF10	E3 SUMO-PROTEIN LIGASE PIAS3
P00059	p53 pathway	P01486	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02738	De novo purine biosynthesis	P02904	Guanylate kinase	SYNY3|EnsemblGenome=BAA16650|UniProtKB=P72648	Guanylate kinase	ISS			PTHR23117:SF13	GUANYLATE KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	MONDO|Ensembl=ENSMODG00000015696|UniProtKB=F7E0Q7	Fructose-bisphosphate aldolase	ISS	84261525	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00640	PI3K	CAEEL|WormBase=WBGene00006932|UniProtKB=Q9TXI7	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	PANTR|Ensembl=ENSPTRG00000004215|UniProtKB=H2Q4M7	Uncharacterized protein	ISS	12356903	PubMed	PTHR10201:SF143	MATRILYSIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000003043|UniProtKB=P63212	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	BOVIN|Ensembl=ENSBTAG00000005800|UniProtKB=F1N3G8	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=17175|UniProtKB=Q9P212	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	10934033	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02747	Histidine biosynthesis	P02992	Imidazol glycerol phosphate synthase	STRCO|EnsemblGenome=CAB51440|UniProtKB=Q9S2T7	Imidazole glycerol phosphate synthase subunit HisF	ISS			PTHR21235:SF2	IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	RAT|RGD=3425|UniProtKB=P97887	Presenilin-1	IDA	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MACMU|Ensembl=ENSMMUG00000017374|UniProtKB=F7H6T7	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	CHICK|Gene=PSEN2|UniProtKB=Q90X07	Presenilin-2	IDA	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P02748	Isoleucine biosynthesis	P02995	Threonine dehydratase	DROME|FlyBase=FBgn0037684|UniProtKB=Q9VHF0	CG8129, isoform B	ISS			PTHR43419:SF8	THREONINE AMMONIA-LYASE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ORYSJ|EnsemblGenome=OS05G0106600|UniProtKB=Q65XH8	Os05g0106600 protein	ISS	14684598	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	DROME|FlyBase=FBgn0000577|UniProtKB=P02836	Segmentation polarity homeobox protein engrailed	IEP	12356903	PubMed	PTHR24341:SF6	HOMEOBOX PROTEIN INVECTED-RELATED
P04393	Ras Pathway	P04557	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P02742	Tetrahydrofolate biosynthesis	P02951	GTP cyclohydrolase	CHICK|Gene=GCH1|UniProtKB=P50141	GTP cyclohydrolase 1	ISS			PTHR11109:SF0	GTP CYCLOHYDROLASE 1
P00012	Cadherin signaling pathway	P00462	Casein kinase II	RAT|RGD=1306882|UniProtKB=B4F7A9	Casein kinase 2, alpha prime polypeptide	ISS	10617630	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MOUSE|MGI=MGI=1933206|UniProtKB=A2AIR5	Protein Grin3a	ISS	11319238	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00012	Cadherin signaling pathway	P00470	F-actin	TRYB2|Gene=Tb09.211.0620|UniProtKB=Q38E94	Actin A	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05918	p38 MAPK pathway	P05920	MAPKAP-K2	HUMAN|HGNC=6887|UniProtKB=P49137	MAP kinase-activated protein kinase 2	RCA	9628873	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00011	Blood coagulation	P00421	alpha1-antitrypsin	RAT|RGD=3326|UniProtKB=P17475	Alpha-1-antiproteinase	ISS	112889	gi	PTHR11461:SF165	ALPHA-1-ANTITRYPSIN-RELATED
P00022	General transcription by RNA polymerase I	P00657	TBP	XENTR|Xenbase=XB-GENE-488460|UniProtKB=Q6DIY4	TATA box-binding protein-like protein 1	ISS	600075	OMIM	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00017	DNA replication	P00534	PCNA	MONDO|Ensembl=ENSMODG00000011649|UniProtKB=F6TIM3	Proliferating cell nuclear antigen	ISS	12893285	PubMed	PTHR11352:SF0	PROLIFERATING CELL NUCLEAR ANTIGEN
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	9860142	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00056	VEGF signaling pathway	P01414	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00053	T cell activation	P01307	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	7492337	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00036	Interleukin signaling pathway	P00985	PDK1/2	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	ISS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00001	Adrenaline and noradrenaline biosynthesis	P00070	VAT2	HUMAN|HGNC=10935|UniProtKB=Q05940	Synaptic vesicular amine transporter	IC	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00018	EGF receptor signaling pathway	P00560	Raf-1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	XENTR|Xenbase=XB-GENE-6053489|UniProtKB=F6S8L5	Tyrosine-protein kinase	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00006	Apoptosis signaling pathway	P00274	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00056	VEGF signaling pathway	P01413	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00548	RKIP	CAEEL|WormBase=WBGene00013477|UniProtKB=Q9XW37	Uncharacterized protein	ISS			PTHR11362:SF44	SUBFAMILY NOT NAMED
P05730	Endogenous cannabinoid signaling	P05743	CB1	MONDO|Ensembl=ENSMODG00000018290|UniProtKB=F6T8W7	Uncharacterized protein	ISS	9888857	PubMed	PTHR22750:SF47	CANNABINOID RECEPTOR 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00718	Phosphorylase a	MONDO|Ensembl=ENSMODG00000013150|UniProtKB=F7ACG9	Alpha-1,4 glucan phosphorylase	ISS	4318782	PubMed	PTHR11468:SF12	GLYCOGEN PHOSPHORYLASE, LIVER FORM
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CHICK|Ensembl=ENSGALG00000001462|UniProtKB=F1NSB8	Adenosine receptor A3	IDA	12515326	PubMed	PTHR24246:SF2	ADENOSINE RECEPTOR A3
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MOUSE|MGI=MGI=2136761|UniProtKB=Q8BKG4	Frizzled-10	ISS	11212302	PubMed	PTHR11309:SF86	FRIZZLED-10
P00019	Endothelin signaling pathway	P00577	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	IGI	14526383	PubMed	PTHR10048:SF14	PI-3 KINASE
P00006	Apoptosis signaling pathway	P00269	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01457	GBeta	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00036	Interleukin signaling pathway	P00990	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IC	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00464	Fyn	HUMAN|HGNC=3955|UniProtKB=P42685	Tyrosine-protein kinase FRK	ISS			PTHR24418:SF296	TYROSINE-PROTEIN KINASE FRK
P00052	TGF-beta signaling pathway	P01284	JNK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MOUSE|MGI=MGI=95819|UniProtKB=P35438	Glutamate receptor ionotropic, NMDA 1	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00038	JAK/STAT signaling pathway	P01031	PIAS	MACMU|Ensembl=ENSMMUG00000004498|UniProtKB=F7GFM9	Protein inhibitor of activated STAT2	ISS	8682149	PubMed	PTHR10782:SF12	E3 SUMO-PROTEIN LIGASE PIAS2
P00006	Apoptosis signaling pathway	P00310	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Ensembl=ENSBTAG00000037985|UniProtKB=F1MCK3	Muscarinic acetylcholine receptor	ISS			PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00045	Notch signaling pathway	P01119	NIct	HUMAN|HGNC=7883|UniProtKB=Q9UM47	Neurogenic locus notch homolog protein 3	IC	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	DICDI|dictyBase=DDB_G0279413|UniProtKB=P05987	cAMP-dependent protein kinase regulatory subunit	ISS	2372396	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00920	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00049	Parkinson disease	P01238	14-3-3	SCHMA|EnsemblGenome=Smp_034840|UniProtKB=G4V8A9	14-3-3 epsilon	IDA	11172812	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00036	Interleukin signaling pathway	P00967	c-fos	BOVIN|Ensembl=ENSBTAG00000004322|UniProtKB=O77628	Proto-oncogene c-Fos	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00012	Cadherin signaling pathway	P00470	F-actin	MACMU|Ensembl=ENSMMUG00000017683|UniProtKB=F6UA63	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	RCA	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00274	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	ISS	96320556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00029	Huntington disease	P00808	Caspase 8	MOUSE|MGI=MGI=1261423|UniProtKB=O89110	Caspase-8	IDA	11788820	PubMed	PTHR10454:SF162	CASPASE-8
P00029	Huntington disease	P00811	Arp2/3 complex	MOUSE|MGI=MGI=1343142|UniProtKB=Q9WV32	Actin-related protein 2/3 complex subunit 1B	TAS	9618202	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P04393	Ras Pathway	P04556	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	ORNAN|Ensembl=ENSOANG00000002061|UniProtKB=F7ANC6	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P02736	Coenzyme A biosynthesis	P02886	Pantetheine-phosphate adenyltransferase	AQUAE|EnsemblGenome=aq_253|UniProtKB=O66614	Phosphopantetheine adenylyltransferase	ISS			PTHR21342:SF1	PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE
P02723	Adenine and hypoxanthine salvage pathway	P02812	Deoxyinosine phosphorylase	ANOGA|EnsemblGenome=AGAP005945|UniProtKB=A4Q998	AGAP005945-PA	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g234494|UniProtKB=A7RU31	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00056	VEGF signaling pathway	P01419	Ets	HUMAN|HGNC=3488|UniProtKB=P14921	Protein C-ets-1	IEP	9157999	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MOUSE|MGI=MGI=102643|UniProtKB=O08638	Myosin-11	ISS	89264452	PubMed	PTHR13140:SF335	MYOSIN-11
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	XENTR|Xenbase=XB-GENE-957124|UniProtKB=F7BDN8	Uncharacterized protein	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	IDA	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P02747	Histidine biosynthesis	P02993	Phosphoribosylformimino-5-amino-1-phosphoribosyl-4 imadazol carboxamide isomerase	THEMA|EnsemblGenome=TM_1037|UniProtKB=Q9X0C7	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase	ISS			PTHR43090:SF2	1- 5-PHOSPHORIBOSYL -5-  5-PHOSPHORIBOSYLAMINO METHYLIDENEAMINO  IMIDAZOLE-4-CARBOXAMIDE ISOMERASE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00321	HSP70	ANOGA|EnsemblGenome=AGAP004581|UniProtKB=A7UT42	AGAP004581-PA	ISS	12150907	PubMed	PTHR19375:SF256	HSP70 PROTEIN-RELATED
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00029	Huntington disease	P00780	Microtubule	MACMU|Ensembl=ENSMMUG00000012164|UniProtKB=F7GW57	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P06664	Gonadotropin-releasing hormone receptor pathway	P06795	STAT3	MOUSE|MGI=MGI=103038|UniProtKB=P42227	Signal transducer and activator of transcription 3	RCA	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P05916	Opioid prodynorphin pathway	P06002	G-protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00899	IRS 1-4	MOUSE|MGI=MGI=1194882|UniProtKB=O54718	Insulin receptor substrate 3, isoform CRA_a (Fragment)	ISS	5031805	gi	PTHR10614:SF8	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00775	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00021	FGF signaling pathway	P00623	FGF	CHICK|Ensembl=ENSGALG00000016866|UniProtKB=F6QFC1	Fibroblast growth factor	ISS			PTHR11486:SF18	FIBROBLAST GROWTH FACTOR 14
P00029	Huntington disease	P00774	Dynein complex	MOUSE|MGI=MGI=107743|UniProtKB=O88485	Cytoplasmic dynein 1 intermediate chain 1	IPI	9454836	PubMed	PTHR12442:SF34	CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN 1
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01451	Galpha	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	TAS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00009	Axon guidance mediated by netrin	P00359	NFAT	RAT|RGD=1307690|UniProtKB=D4A0I8	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (Predicted), isoform CRA_b	ISS	9462517	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00890	ELK	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	3183861	gi	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	RCA	176892	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_79607|UniProtKB=C3ZHN4	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P06959	CCKR signaling map	P07076	PRAS40	HUMAN|HGNC=28426|UniProtKB=Q96B36	Proline-rich AKT1 substrate 1	RCA	19339977	PubMed	PTHR21844:SF2	PROLINE-RICH AKT1 SUBSTRATE 1
P00021	FGF signaling pathway	P00629	PP2A	XENTR|Xenbase=XB-GENE-971147|UniProtKB=F7AB62	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B	ISS	11956189	PubMed	PTHR11871:SF2	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00046	Oxidative stress response	P01138	MKK4	MONDO|Ensembl=ENSMODG00000008266|UniProtKB=F6Z879	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	ARATH|TAIR=AT3G43810|UniProtKB=P59220	Calmodulin-7	ISS	3885394	PubMed	PTHR23050:SF250	CALMODULIN-7
P00005	Angiogenesis	P00200	Dsh	DANRE|ZFIN=ZDB-GENE-010319-1|UniProtKB=B8JMI2	Uncharacterized protein	ISS	11212302	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00012	Cadherin signaling pathway	P00477	GSK3beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	PANTR|Ensembl=ENSPTRG00000017236|UniProtKB=H2QRH6	Uncharacterized protein	ISS	11266476	PubMed	PTHR10373:SF33	TRANSCRIPTION FACTOR 7
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BOVIN|Ensembl=ENSBTAG00000002664|UniProtKB=F1N7G3	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF84	PROTEIN WNT-9B
P00005	Angiogenesis	P00244	MAPKAPK2/3	PANTR|Ensembl=ENSPTRG00000014968|UniProtKB=H2QMP5	Mitogen-activated protein kinase-activated protein kinase 3	ISS	11157753	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	RAT|RGD=1304632|UniProtKB=D3ZS84	Protein Socs6	ISS	15032587	PubMed	PTHR44562:SF1	SUPPRESSOR OF CYTOKINE SIGNALING 6
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00057	Wnt signaling pathway	P01471	alpha-catenin	MOUSE|MGI=MGI=88275|UniProtKB=Q61301	Catenin alpha-2	IDA	1768802	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	XENTR|Xenbase=XB-GENE-478210|UniProtKB=F6V5F4	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF23	FRIZZLED-4
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	BOVIN|Ensembl=ENSBTAG00000000219|UniProtKB=F1MCL3	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00053	T cell activation	P01336	Jnk	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00006	Apoptosis signaling pathway	P00269	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04398	p53 pathway feedback loops 2	G04714	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	IGI	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00059	p53 pathway	G04694	p110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	BOVIN|Ensembl=ENSBTAG00000001137|UniProtKB=P04973	Clathrin light chain A	IDA	11889126	PubMed	PTHR10639:SF1	CLATHRIN LIGHT CHAIN A
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IDA	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	RCA	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	PANTR|Ensembl=ENSPTRG00000018449|UniProtKB=H2QTG5	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00005	Angiogenesis	P00200	Dsh	BOVIN|Ensembl=ENSBTAG00000003075|UniProtKB=E1BK34	Uncharacterized protein	ISS	11212302	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2743|UniProtKB=P31421	Metabotropic glutamate receptor 2	IDA	9407094	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00010	B cell activation	P00385	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12176041	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00583	cPLA2	CANLF|Ensembl=ENSCAFG00000013778|UniProtKB=F6UQ33	Phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00021	FGF signaling pathway	P00642	MEK1-2	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	IDA	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000040439|UniProtKB=F6Q2H9	Uncharacterized protein	ISS	2156831	PubMed	PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P00048	PI3 kinase pathway	P01199	Galpha	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00973	PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	RAT|RGD=2869|UniProtKB=P24062	Insulin-like growth factor 1 receptor	ISS	249616	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	SCHPO|PomBase=SPAC8C9.03|UniProtKB=P36600	cAMP-dependent protein kinase regulatory subunit	IC	176892	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P04393	Ras Pathway	P04570	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01227	20S proteasome	PANTR|Ensembl=ENSPTRG00000003385|UniProtKB=H2Q378	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF12	PROTEASOME SUBUNIT ALPHA TYPE-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MOUSE|MGI=MGI=1346044|UniProtKB=Q9WVM6	Tolloid-like protein 2	TAS	9759503	PubMed	PTHR43978:SF1	TOLLOID-LIKE PROTEIN 2
P00006	Apoptosis signaling pathway	P00274	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01159	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CHICK|Ensembl=ENSGALG00000017238|UniProtKB=F1NWG3	Uncharacterized protein	IDA	9407094	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00034	Integrin signalling pathway	P00924	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	TAS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P02772	Pyruvate metabolism	P03140	Pyruvate Carboxylase	HUMAN|HGNC=8636|UniProtKB=P11498	Pyruvate carboxylase, mitochondrial	TAS	12112657	PubMed	PTHR43778:SF2	PYRUVATE CARBOXYLASE, MITOCHONDRIAL
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00036	Interleukin signaling pathway	P00983	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00034	Integrin signalling pathway	P00916	Ras	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	IPI	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00034	Integrin signalling pathway	P00951	Jnk	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IDA	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05754	Ggamma	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04393	Ras Pathway	P04571	Tiam1	RAT|RGD=1307455|UniProtKB=D3ZWV8	Protein Tiam1	ISS	11130063	PubMed	PTHR22826:SF88	T-LYMPHOMA INVASION AND METASTASIS-INDUCING PROTEIN 1
P00053	T cell activation	P01311	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00019	Endothelin signaling pathway	P00589	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00636	FGFR1-4	HUMAN|HGNC=3691|UniProtKB=P22455	Fibroblast growth factor receptor 4	IGI	93194827	PubMed	PTHR24416:SF343	FIBROBLAST GROWTH FACTOR RECEPTOR 4
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	HUMAN|HGNC=11589|UniProtKB=P62380	TATA box-binding protein-like protein 1	ISS	10082669	PubMed	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00021	FGF signaling pathway	P00633	Ras	SCLS1|EnsemblGenome=SS1G_13801|UniProtKB=A7F871	Uncharacterized protein	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MOUSE|MGI=MGI=1915115|UniProtKB=Q9CQE5	Regulator of G-protein signaling 10	IDA	8756726	PubMed	PTHR10845:SF182	REGULATOR OF G-PROTEIN SIGNALING 10
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	MACMU|Ensembl=ENSMMUG00000009679|UniProtKB=F6YBQ8	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Ensembl=ENSPTRG00000016548|UniProtKB=H2QQC5	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00582	COX-2	MACMU|Ensembl=ENSMMUG00000016857|UniProtKB=F7BWZ9	Uncharacterized protein	ISS	97393071	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P00034	Integrin signalling pathway	P00916	Ras	HUMAN|HGNC=10447|UniProtKB=P10301	Ras-related protein R-Ras	IPI	7997267	PubMed	PTHR24070:SF245	RAS-RELATED PROTEIN R-RAS
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00047	PDGF signaling pathway	P01151	PKB	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00045	Notch signaling pathway	P01120	NIcs	MACMU|Ensembl=ENSMMUG00000018375|UniProtKB=F7H1D5	Neurogenic locus notch homolog protein 2 isoform 1 preproprotein	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00047	PDGF signaling pathway	P01174	Rho	PANTR|Ensembl=ENSPTRG00000005773|UniProtKB=H2Q7E7	Uncharacterized protein	ISS			PTHR12659:SF6	STAR-RELATED LIPID TRANSFER PROTEIN 13
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	HUMAN|HGNC=4584|UniProtKB=Q05586	Glutamate receptor ionotropic, NMDA 1	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	94179345	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00006	Apoptosis signaling pathway	P00318	PKCs	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00048	PI3 kinase pathway	P01188	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	HUMAN|HGNC=6904|UniProtKB=P31153	S-adenosylmethionine synthase isoform type-2	ISS			PTHR11964:SF12	S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	LEIMA|EnsemblGenome=LmjF.33.0792|UniProtKB=Q4Q4C4	Beta tubulin	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00036	Interleukin signaling pathway	P00989	Ets	MACMU|Ensembl=ENSMMUG00000023453|UniProtKB=F7F0F3	Transcription factor Spi-B	ISS	8970723	PubMed	PTHR11849:SF174	TRANSCRIPTION FACTOR SPI-B
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	RAT|RGD=1589817|UniProtKB=B0BNE2	DNA-directed RNA polymerases I, II, and III subunit RPABC1	ISS			PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02734	Chorismate biosynthesis	P02868	Chorismate synthase	SCHPO|PomBase=SPCC1223.14|UniProtKB=O74413	Chorismate synthase	ISS			PTHR21085:SF0	CHORISMATE SYNTHASE
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	RAT|RGD=619731|UniProtKB=Q9QYP1	Low-density lipoprotein receptor-related protein 4	ISS	11907044	PubMed	PTHR44017:SF4	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4
P00047	PDGF signaling pathway	P01142	p90RSK	PANTR|Ensembl=ENSPTRG00000006631|UniProtKB=H2Q8S3	Ribosomal protein S6 kinase	ISS	9687510	PubMed	PTHR24351:SF115	RIBOSOMAL PROTEIN S6 KINASE ALPHA-5
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IGI	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	IC	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00055	Transcription regulation by bZIP transcription factor	P01398	TFIIEalpha	CANLF|Ensembl=ENSCAFG00000011306|UniProtKB=E2R3P2	Uncharacterized protein	ISS	189964	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00050	Plasminogen activating cascade	P01244	PAI-2	MACMU|Ensembl=ENSMMUG00000016617|UniProtKB=F6TWU5	Uncharacterized protein	ISS	11929770	PubMed	PTHR11461:SF61	PLASMINOGEN ACTIVATOR INHIBITOR 2
P00059	p53 pathway	P01486	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000000289|UniProtKB=F7A9T0	Uncharacterized protein	ISS	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00005	Angiogenesis	P00243	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	G04714	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00018	EGF receptor signaling pathway	P00551	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00118	E-cadherin	MACMU|Ensembl=ENSMMUG00000010393|UniProtKB=F7D992	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P00010	B cell activation	P00383	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00782	alpha-Adaptin	DICDI|dictyBase=DDB_G0273439|UniProtKB=Q86KI1	AP-2 complex subunit alpha-2	IDA	11532990	PubMed	PTHR22780:SF4	AP-2 COMPLEX SUBUNIT ALPHA-2
P02775	Salvage pyrimidine ribonucleotides	P03151	Uracil phosphoribosyl  transferase	MONDO|Ensembl=ENSMODG00000025227|UniProtKB=F7DU02	Uncharacterized protein	ISS			PTHR10285:SF90	URACIL PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014262|UniProtKB=F7BYS8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	BOVIN|Ensembl=ENSBTAG00000006898|UniProtKB=G3X6L9	Uncharacterized protein	ISS			PTHR43382:SF2	BIFUNCTIONAL GLUTAMATE/PROLINE--TRNA LIGASE
P06959	CCKR signaling map	P07055	SNAI1	HUMAN|HGNC=11128|UniProtKB=O95863	Zinc finger protein SNAI1	RCA	20637111	PubMed	PTHR44037:SF4	ZINC FINGER PROTEIN SNAI1
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MACMU|Ensembl=ENSMMUG00000011852|UniProtKB=F7H4T8	Receptor protein serine/threonine kinase	ISS	10683140	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00052	TGF-beta signaling pathway	P01284	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00629	PP2A	BOVIN|Ensembl=ENSBTAG00000000469|UniProtKB=P67774	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	DROME|FlyBase=FBgn0011286|UniProtKB=Q24498	Ryanodine receptor	ISS	8930069	PubMed	PTHR13715:SF79	RYANODINE RECEPTOR
P00034	Integrin signalling pathway	P00944	Actin	DANRE|ZFIN=ZDB-GENE-000329-3|UniProtKB=Q7ZVF9	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00054	Toll receptor signaling pathway	P01369	MKK1	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	BOVIN|Ensembl=ENSBTAG00000014674|UniProtKB=P41985	Muscarinic acetylcholine receptor M2	ISS	8100450	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00047	PDGF signaling pathway	P01169	Vav	CANLF|Ensembl=ENSCAFG00000019951|UniProtKB=F1PET4	Uncharacterized protein	ISS	14623913	PubMed	PTHR22826:SF97	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	176910	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	TAKRU|Ensembl=ENSTRUG00000008018|UniProtKB=H2T5N4	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00906	Rap1	BOVIN|Ensembl=ENSBTAG00000008967|UniProtKB=P61223	Ras-related protein Rap-1b	ISS	8576107	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00009	Axon guidance mediated by netrin	P00366	Rac	MACMU|Ensembl=ENSMMUG00000021075|UniProtKB=F7GY91	Uncharacterized protein	ISS	11756405	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00020	FAS signaling pathway	P00594	Caspase8	MACMU|Ensembl=ENSMMUG00000031296|UniProtKB=F7C587	Uncharacterized protein	ISS	11788820	PubMed	PTHR10454:SF162	CASPASE-8
P00010	B cell activation	P00373	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IGI	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00560	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00053	T cell activation	P01300	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00059	p53 pathway	G01581	BAX	RAT|RGD=2192|UniProtKB=Q63690	Apoptosis regulator BAX	ISS	14963330	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P00047	PDGF signaling pathway	P01147	Nck	MONDO|Ensembl=ENSMODG00000018540|UniProtKB=F7GD33	Uncharacterized protein	ISS	11689432	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	CHICK|Gene=CHRM3|UniProtKB=P49578	Muscarinic acetylcholine receptor M3	ISS	10069496	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00018	EGF receptor signaling pathway	P00560	Raf-1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IGI	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05918	p38 MAPK pathway	P06025	SRF	CANLF|Ensembl=ENSCAFG00000001829|UniProtKB=F1PH12	Uncharacterized protein	ISS	15647354	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P05731	GABA-B receptor II signaling	P05753	Ca channel	HUMAN|HGNC=1388|UniProtKB=O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	15699344	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00029	Huntington disease	P00799	JNK-2	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	IC	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00017	DNA replication	P00530	Top	MACMU|Ensembl=ENSMMUG00000008941|UniProtKB=F7EVK2	DNA topoisomerase 2	RCA			PTHR10169:SF46	DNA TOPOISOMERASE 2-ALPHA
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	227170	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	TAS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01067	AChE	CAEEL|WormBase=WBGene00000037|UniProtKB=Q9U295	Carboxylic ester hydrolase	IC			PTHR43918:SF5	CHOLINESTERASE
P00012	Cadherin signaling pathway	P00466	EGFR	MOUSE|MGI=MGI=95294|UniProtKB=Q01279	Epidermal growth factor receptor	ISS	21100872	PubMed	PTHR24416:SF91	EPIDERMAL GROWTH FACTOR RECEPTOR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=94924|UniProtKB=P61168	D(2) dopamine receptor	IDA	1319557	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00036	Interleukin signaling pathway	P00965	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CHICK|Ensembl=ENSGALG00000027684|UniProtKB=P09653	Tubulin beta-5 chain	ISS	12932731	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	BOVIN|Ensembl=ENSBTAG00000011723|UniProtKB=E1BKL6	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00012	Cadherin signaling pathway	P00470	F-actin	TAKRU|Ensembl=ENSTRUG00000014318|UniProtKB=H2UI49	Uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	MOUSE|MGI=MGI=2685720|UniProtKB=Q14DH7	Acyl-CoA synthetase short-chain family member 3, mitochondrial	ISS			PTHR43347:SF3	ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL
P00021	FGF signaling pathway	P00624	14-3-3	DROME|FlyBase=FBgn0004907|UniProtKB=P29310	14-3-3 protein zeta	ISS	10407019	PubMed	PTHR18860:SF13	14-3-3 PROTEIN ZETA
P00054	Toll receptor signaling pathway	P01369	MKK1	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	RAT|RGD=62045|UniProtKB=Q99PS2	Casein kinase1 epsilon-2	ISS	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00049	Parkinson disease	P01234	GRK	HUMAN|HGNC=290|UniProtKB=P35626	Beta-adrenergic receptor kinase 2	IDA	8288567	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	TAS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00045	Notch signaling pathway	P01120	NIcs	HUMAN|HGNC=7881|UniProtKB=P46531	Neurogenic locus notch homolog protein 1	IGI	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	HUMAN|HGNC=9281|UniProtKB=P62136	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit	ISS	10433257	PubMed	PTHR11668:SF377	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-ALPHA CATALYTIC SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00057	Wnt signaling pathway	P01456	beta-arrestin	CANLF|Ensembl=ENSCAFG00000005415|UniProtKB=F1PQM2	Uncharacterized protein	ISS	4757780	gi	PTHR11792:SF22	BETA-ARRESTIN-1
P00009	Axon guidance mediated by netrin	P00359	NFAT	BOVIN|Ensembl=ENSBTAG00000004368|UniProtKB=F1MSU2	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	BOVIN|Ensembl=ENSBTAG00000046248|UniProtKB=Q58CQ2	Actin-related protein 2/3 complex subunit 1B	ISS	9618202	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04653	cdk2	DANRE|ZFIN=ZDB-GENE-040426-2741|UniProtKB=Q7ZWB1	Cyclin-dependent kinase 2	ISS	15660127	PubMed	PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P00057	Wnt signaling pathway	P01454	betaTrCP	XENTR|Xenbase=XB-GENE-486122|UniProtKB=F6XVN5	Uncharacterized protein (Fragment)	ISS	10074433	PubMed	PTHR44038:SF2	F-BOX/WD REPEAT-CONTAINING PROTEIN 1A
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P02783	Tryptophan biosynthesis	P03209	Anthranilate phosphoribosyl transferase	STRCO|EnsemblGenome=CAB38583|UniProtKB=Q9Z4W9	Anthranilate phosphoribosyltransferase 2	ISS			PTHR43285:SF2	ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	MACMU|Ensembl=ENSMMUG00000020819|UniProtKB=F7HSM1	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00786	ARF	TAKRU|Ensembl=ENSTRUG00000011714|UniProtKB=H2TY29	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	TAS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	ARATH|TAIR=AT1G67220|UniProtKB=Q9FYH1	Histone acetyltransferase HAC2	TAS	10823891	PubMed	PTHR13808:SF6	HISTONE ACETYLTRANSFERASE HAC2
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00059	p53 pathway	G01579	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00021	FGF signaling pathway	P00642	MEK1-2	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IGI	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00059	p53 pathway	P04630	PP2A	XENTR|Xenbase=XB-GENE-484003|UniProtKB=Q6P365	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	DANRE|ZFIN=ZDB-GENE-040718-93|UniProtKB=Q6DGZ5	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00056	VEGF signaling pathway	P01425	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00977	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IC	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00049	Parkinson disease	P01208	Hsp70	SCHPO|PomBase=SPAC13G7.02c|UniProtKB=Q10265	Probable heat shock protein ssa1	IDA	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00047	PDGF signaling pathway	P01174	Rho	DROME|FlyBase=FBgn0026375|UniProtKB=Q9VX32	Rho GTPase-activating protein 190	ISS			PTHR23175:SF4	RHO GTPASE-ACTIVATING PROTEIN 190
P00048	PI3 kinase pathway	P01177	P110ACT	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	RAT|RGD=1565398|UniProtKB=D3ZUL3	Protein Col6a1	ISS	10727440	PubMed	PTHR44172:SF3	COLLAGEN ALPHA-1 VI  CHAIN
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=30035|UniProtKB=Q8WYR1	Phosphoinositide 3-kinase regulatory subunit 5	ISS	129387	gi	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P02751	Lysine biosynthesis	P03009	Aspartokinase	BACTN|EnsemblGenome=BT_1375|UniProtKB=Q8A7Z9	Aspartokinase	ISS			PTHR21499:SF38	ASPARTOKINASE 1, CHLOROPLASTIC
P04393	Ras Pathway	P04557	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IDA	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00029	Huntington disease	P00790	beta-Tubulin	ARATH|TAIR=AT1G75780|UniProtKB=P12411	Tubulin beta-1 chain	TAS	12932731	PubMed	PTHR11588:SF116	TUBULIN BETA-1 CHAIN-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	BOVIN|Ensembl=ENSBTAG00000000219|UniProtKB=F1MCL3	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00058	mRNA splicing	P01474	U5	MONDO|Ensembl=ENSMODG00000017078|UniProtKB=F6VKV2	Uncharacterized protein	ISS	9774689	PubMed	PTHR44006:SF1	U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN
P00034	Integrin signalling pathway	P00941	Integrin alpha	CHICK|Gene=ITGA6|UniProtKB=P26007	Integrin alpha-6	IPI	3487386	PubMed	PTHR23220:SF9	INTEGRIN ALPHA-6
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00059	p53 pathway	P04630	PP2A	IXOSC|EnsemblGenome=ISCW014549|UniProtKB=B7QGY5	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DROME|FlyBase=FBgn0001122|UniProtKB=P16378	G protein alpha o subunit	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00562	p38	CAEEL|WormBase=WBGene00004055|UniProtKB=Q17446	Mitogen-activated protein kinase pmk-1	IGI	11703092	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00048	PI3 kinase pathway	P01199	Galpha	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	IC	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05916	Opioid prodynorphin pathway	P06000	vasopressin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00037	Ionotropic glutamate receptor pathway	P01026	KA	DANRE|Ensembl=ENSDARG00000070511|UniProtKB=E7F5R2	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF282	GLUTAMATE RECEPTOR-RELATED
P02723	Adenine and hypoxanthine salvage pathway	P02808	Deoxyadenosine phosphorylase	MACMU|Ensembl=ENSMMUG00000019126|UniProtKB=F6T0Z6	Purine nucleoside phosphorylase	ISS			PTHR11904:SF12	PURINE NUCLEOSIDE PHOSPHORYLASE
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00047	PDGF signaling pathway	P01162	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06754	Ggamma	MOUSE|MGI=MGI=102705|UniProtKB=P63213	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	RCA	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	PANTR|Ensembl=ENSPTRG00000012514|UniProtKB=H2QIT0	Serine/threonine-protein kinase receptor	ISS	11252892	PubMed	PTHR23255:SF64	ACTIVIN RECEPTOR TYPE-2A
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	RCA	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CANLF|Ensembl=ENSCAFG00000015708|UniProtKB=F2Z4N0	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00045	Notch signaling pathway	G01541	E(spl)-C genes	DROME|FlyBase=FBgn0001168|UniProtKB=P14003	Protein hairy	TAS	14973298	PubMed	PTHR10985:SF77	GH26014P-RELATED
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IGI	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00034	Integrin signalling pathway	P00951	Jnk	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00034	Integrin signalling pathway	P00906	Rap1	MONDO|Ensembl=ENSMODG00000008543|UniProtKB=F7DH11	Uncharacterized protein	ISS	8576107	PubMed	PTHR24070:SF221	RAS-RELATED PROTEIN RAP-2A
P00017	DNA replication	P00527	Histones	SCHPO|PomBase=SPBC1105.11c|UniProtKB=P10651	Histone H3.3	ISS	12413958	PubMed	PTHR11426:SF47	SUBFAMILY NOT NAMED
P00049	Parkinson disease	P01211	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	IDA	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00021	FGF signaling pathway	P00632	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00047	PDGF signaling pathway	P01162	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00049	Parkinson disease	P01238	14-3-3	ORYSJ|EnsemblGenome=OS08G0430500|UniProtKB=Q6ZKC0	14-3-3-like protein GF14-C	IDA	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000002693|UniProtKB=H2R3N8	Uncharacterized protein	ISS	8120095	PubMed	PTHR44506:SF1	CADHERIN-RELATED FAMILY MEMBER 1
P00034	Integrin signalling pathway	P00924	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	MACMU|Ensembl=ENSMMUG00000015149|UniProtKB=F6UE22	Uncharacterized protein	ISS			PTHR15060:SF0	INTERLEUKIN-15 RECEPTOR SUBUNIT ALPHA
P02756	N-acetylglucosamine metabolism	P03040	N-acetylneuraminate lyase	MACMU|Ensembl=ENSMMUG00000008992|UniProtKB=F7EKQ9	Uncharacterized protein	ISS			PTHR12128:SF21	N-ACETYLNEURAMINATE LYASE
P00018	EGF receptor signaling pathway	P00539	14-3-3	PANTR|Ensembl=ENSPTRG00000019320|UniProtKB=H2QUT2	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	ISS	99360936	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00029	Huntington disease	P00799	JNK-2	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	MONDO|Ensembl=ENSMODG00000001807|UniProtKB=F6Y7R9	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00892	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	10521483	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=1930705|UniProtKB=P61264	Syntaxin-1B	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00030	Hypoxia response via HIF activation	P00819	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	TAS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	TAS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P02788	Xanthine and guanine salvage pathway	P03250	Guanosine phosphorylase	MOUSE|MGI=MGI=3712328|UniProtKB=Q9D8C9	Purine nucleoside phosphorylase	ISS	7903568	PubMed	PTHR11904:SF12	PURINE NUCLEOSIDE PHOSPHORYLASE
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00589	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IGI	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IDA	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00010	B cell activation	P00367	NFAT	MACMU|Ensembl=ENSMMUG00000003370|UniProtKB=F7E8G2	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=11433|UniProtKB=Q16623	Syntaxin-1A	ISS	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00012	Cadherin signaling pathway	P00476	Yes	MOUSE|MGI=MGI=96892|UniProtKB=P25911	Tyrosine-protein kinase Lyn	ISS			PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P05730	Endogenous cannabinoid signaling	P05746	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00012	Cadherin signaling pathway	P00463	betacatenin	PANTR|Ensembl=ENSPTRG00000023062|UniProtKB=H2R2U1	Catenin (Cadherin-associated protein), beta 1, 88kDa	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00047	PDGF signaling pathway	P01160	IP3 receptor	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02777	Succinate to proprionate conversion	P03163	Methylmalonyl-CoA decarboxylase	MACMU|Ensembl=ENSMMUG00000003262|UniProtKB=F7DJ09	Propionyl-CoA carboxylase beta chain, mitochondrial isoform 1	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P04395	Vasopressin synthesis	P04597	Signal Peptide	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	DANRE|ZFIN=ZDB-GENE-040426-2575|UniProtKB=E7FC99	Uncharacterized protein	ISS			PTHR23315:SF68	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000006582|UniProtKB=E1BFV6	Uncharacterized protein	ISS	12181435	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IGI	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00047	PDGF signaling pathway	P01143	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	20331588	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CAEEL|WormBase=WBGene00001613|UniProtKB=Q10914	Glutamate receptor 2	IC	8804111	PubMed	PTHR18966:SF270	GLUTAMATE RECEPTOR 1-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00021	FGF signaling pathway	P00627	ERK1-2	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00012	Cadherin signaling pathway	P00475	Frizzled	HUMAN|HGNC=4045|UniProtKB=O75084	Frizzled-7	IDA	8717036	PubMed	PTHR11309:SF31	FRIZZLED-7
P04393	Ras Pathway	P04570	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05913	Enkephalin release	P05974	G-Protein (i)	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	IC	11535291	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00896	Insulin IGF	ORNAN|Ensembl=ENSOANG00000005566|UniProtKB=F6PZT8	Uncharacterized protein	ISS			PTHR11454:SF4	INSULIN-LIKE GROWTH FACTOR I
P00021	FGF signaling pathway	P00634	MEKK1-5	HUMAN|HGNC=6855|UniProtKB=Q99759	Mitogen-activated protein kinase kinase kinase 3	IGI	9006902	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00021	FGF signaling pathway	P00646	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	DANRE|ZFIN=ZDB-GENE-040426-2738|UniProtKB=E7FBI4	Uncharacterized protein	ISS			PTHR24070:SF289	SUBFAMILY NOT NAMED
P04395	Vasopressin synthesis	P04593	Glycopeptide	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	IC	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04456	ProCRF (Pro Corticotropin-Releasing Factor)	PANTR|Ensembl=ENSPTRG00000020304|UniProtKB=H2QW88	Uncharacterized protein	ISS	122560	OMIM	PTHR15035:SF9	CORTICOLIBERIN
P02757	O-antigen biosynthesis	P03050	dTDP-4-dehydrorhamnose reductase	FUSNN|EnsemblGenome=FN1698|UniProtKB=Q8RIB0	dTDP-4-dehydrorhamnose reductase	ISS			PTHR10491:SF4	METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02920	dCTP deaminase	IXOSC|EnsemblGenome=ISCW020789|UniProtKB=B7PXR7	Putative uncharacterized protein (Fragment)	ISS			PTHR11079:SF149	TRNA-SPECIFIC ADENOSINE DEAMINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEEL|WormBase=WBGene00018620|UniProtKB=O44588	Uncharacterized protein	ISS	3755548	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P00025	Hedgehog signaling pathway	P00691	CBP	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P05734	Synaptic vesicle trafficking	P05773	Munc13	PANTR|Ensembl=ENSPTRG00000020906|UniProtKB=H2QZE0	Uncharacterized protein	ISS	605836	OMIM	PTHR10480:SF8	PROTEIN UNC-13 HOMOLOG B
P00036	Interleukin signaling pathway	P00965	ERK	RAT|RGD=62087|UniProtKB=P27704	Mitogen-activated protein kinase 6	ISS	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00054	Toll receptor signaling pathway	P01369	MKK1	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04393	Ras Pathway	P04559	Rac	CHICK|Ensembl=ENSGALG00000002859|UniProtKB=F6UBD2	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00035	Interferon-gamma signaling pathway	P00960	PTP	MONDO|Ensembl=ENSMODG00000003120|UniProtKB=F6WVD2	Tyrosine-protein phosphatase non-receptor type	ISS	1382983	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00045	Notch signaling pathway	P01101	Su(H)	MACMU|Ensembl=ENSMMUG00000015828|UniProtKB=F7CE90	Recombining binding protein suppressor of hairless isoform 4	ISS	8406481	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00012	Cadherin signaling pathway	P00475	Frizzled	MOUSE|MGI=MGI=108474|UniProtKB=Q61089	Frizzled-6	IDA	11212302	PubMed	PTHR11309:SF75	FRIZZLED-6
P05913	Enkephalin release	P05972	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	14744463	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00547	PP2A	HUMAN|HGNC=9299|UniProtKB=P67775	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	IGI	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01275	P38	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	8925912	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00018	EGF receptor signaling pathway	P00552	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P06664	Gonadotropin-releasing hormone receptor pathway	P06739	MEK1/2	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	RCA	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04393	Ras Pathway	P04559	Rac	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS	15470041	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000009085|UniProtKB=H2RDQ2	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00025	Hedgehog signaling pathway	P00697	Sap18	MACMU|Ensembl=ENSMMUG00000010416|UniProtKB=F7CXR4	Uncharacterized protein	ISS	11960000	PubMed	PTHR13082:SF0	HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18
P04395	Vasopressin synthesis	P04589	Signal Peptidase	MACMU|Ensembl=ENSMMUG00000017370|UniProtKB=F7H6U6	Uncharacterized protein	ISS			PTHR13202:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 1
P00021	FGF signaling pathway	P00639	Shc	PANTR|Ensembl=ENSPTRG00000021091|UniProtKB=H2QXF3	Uncharacterized protein	ISS	96404502	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	IGI	9851932	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00023	General transcription regulation	P00659	TFIIEbeta	CAEEL|WormBase=WBGene00010054|UniProtKB=G5EG47	Transcription initiation factor IIE subunit beta	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P00021	FGF signaling pathway	P00627	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	11251832	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00047	PDGF signaling pathway	P01159	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000014562|UniProtKB=F7GT10	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF60	PROTOCADHERIN ALPHA-2
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DAPPU|EnsemblGenome=DAPPUDRAFT_206575|UniProtKB=E9FUX0	Guanine nucleotide binding protein, beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	DROME|FlyBase=FBgn0026136|UniProtKB=O96863	Casein kinase II subunit beta'	IDA	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00045	Notch signaling pathway	P01120	NIcs	HUMAN|HGNC=7883|UniProtKB=Q9UM47	Neurogenic locus notch homolog protein 3	IC	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P04393	Ras Pathway	P04578	Rho	DANRE|ZFIN=ZDB-GENE-040718-144|UniProtKB=Q6DHE8	Rho-related GTP-binding protein RhoA-D	ISS	12024019	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	DANRE|ZFIN=ZDB-GENE-030131-8783|UniProtKB=Q52WY2	Ras-like protein Cdc42a	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00019	Endothelin signaling pathway	P00591	PLCbeta	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04375	5HT3 type receptor mediated signaling pathway	P04425	K+ channel	PANTR|Ensembl=ENSPTRG00000020614|UniProtKB=H2QWR7	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	MACMU|Ensembl=ENSMMUG00000019504|UniProtKB=F7D2Y0	Uncharacterized protein	ISS	14724059	PubMed	PTHR11699:SF102	RETINAL DEHYDROGENASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	TAS	2837282	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	BACSU|EnsemblGenome=BSU01780|UniProtKB=P0CI73	Glutamine--fructose-6-phosphate aminotransferase [isomerizing]	ISS			PTHR10937:SF0	GH12731P-RELATED
P00018	EGF receptor signaling pathway	P00558	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00029	Huntington disease	G01535	PIG3	RAT|RGD=1308943|UniProtKB=Q3MIE4	Synaptic vesicle membrane protein VAT-1 homolog	ISS	12932731	PubMed	PTHR44054:SF1	SYNAPTIC VESICLE MEMBRANE PROTEIN VAT-1 HOMOLOG
P05918	p38 MAPK pathway	P06013	ELK	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	9644975	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00003	Alzheimer disease-amyloid secretase pathway	P00089	Pen-2	RAT|RGD=1312037|UniProtKB=Q6QI68	Gamma-secretase subunit PEN-2	IDA	12110170	PubMed	PTHR16318:SF0	GAMMA-SECRETASE SUBUNIT PEN-2
P00049	Parkinson disease	P01231	gamma-Synuclein	HUMAN|HGNC=11141|UniProtKB=O76070	Gamma-synuclein	NAS			PTHR13820:SF10	GAMMA-SYNUCLEIN
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CANLF|Ensembl=ENSCAFG00000013148|UniProtKB=Q5R1P3	Glutamate receptor ionotropic, NMDA 2B	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00049	Parkinson disease	P01212	p38 MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00011	Blood coagulation	P00442	FXII	PANTR|Ensembl=ENSPTRG00000017583|UniProtKB=H2QS39	Uncharacterized protein	ISS	4503629	gi	PTHR44246:SF3	COAGULATION FACTOR XII
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000002339|UniProtKB=H2R368	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00005	Angiogenesis	P00208	MEKK1	PANTR|Ensembl=ENSPTRG00000016891|UniProtKB=H2R5K3	Uncharacterized protein	ISS	8940199	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00020	FAS signaling pathway	P00615	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	TAS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00059	p53 pathway	G01579	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05731	GABA-B receptor II signaling	P05760	AC	RAT|RGD=1309318|UniProtKB=D4A3N4	Adenylate cyclase 1 (Predicted)	ISS	2491850	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P00049	Parkinson disease	P01232	CASK	XENTR|Xenbase=XB-GENE-1014725|UniProtKB=F6UGQ3	Uncharacterized protein	ISS	11679592	PubMed	PTHR23122:SF40	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P00010	B cell activation	P00367	NFAT	RAT|RGD=1310749|UniProtKB=D3Z9H7	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	ISS	9462517	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	EMENI|EnsemblGenome=CADANIAG00007636|UniProtKB=P10874	Tubulin beta-2 chain	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00006	Apoptosis signaling pathway	P00276	TRAIL-R	PANTR|Ensembl=ENSPTRG00000020072|UniProtKB=H2QVV9	Uncharacterized protein	ISS			PTHR23097:SF143	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10C-RELATED
P00046	Oxidative stress response	P01121	MKK3/6	BOVIN|Ensembl=ENSBTAG00000010576|UniProtKB=A4IFH7	MAP2K3 protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00057	Wnt signaling pathway	P01435	SWI/SNF	YEAST|SGD=S000003712|UniProtKB=P32591	SWI/SNF complex subunit SWI3	IDA	11532957	PubMed	PTHR12802:SF41	BRAHMA ASSOCIATED PROTEIN 155 KDA
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00049	Parkinson disease	P01208	Hsp70	ANOGA|EnsemblGenome=AGAP002076|UniProtKB=A7UVK8	AGAP002076-PA	IDA	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00557	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	IGI	9620264	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00047	PDGF signaling pathway	P01159	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00053	T cell activation	P01331	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00005	Angiogenesis	P00211	GSK3beta	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00029	Huntington disease	P00787	MAPKK4	HUMAN|HGNC=6844|UniProtKB=P45985	Dual specificity mitogen-activated protein kinase kinase 4	NAS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	MACMU|Ensembl=ENSMMUG00000006253|UniProtKB=F7H582	Uncharacterized protein	ISS	92357702	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00049	Parkinson disease	P01242	Casein kinase I	RAT|RGD=621408|UniProtKB=Q62763	Casein kinase I isoform gamma-3	IDA	11437445	PubMed	PTHR11909:SF151	CASEIN KINASE I ISOFORM GAMMA-3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00018	EGF receptor signaling pathway	P00552	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P05916	Opioid prodynorphin pathway	P06002	G-protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	ISS	11535291	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P05734	Synaptic vesicle trafficking	P05773	Munc13	BOVIN|Ensembl=ENSBTAG00000011397|UniProtKB=F1MP30	Uncharacterized protein	ISS	605836	OMIM	PTHR10480:SF8	PROTEIN UNC-13 HOMOLOG B
P06664	Gonadotropin-releasing hormone receptor pathway	P06785	ELK1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	RCA	10487205	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	DANRE|ZFIN=ZDB-GENE-030131-8783|UniProtKB=Q52WY2	Ras-like protein Cdc42a	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00018	EGF receptor signaling pathway	P00564	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P06959	CCKR signaling map	G06977	PAI2	HUMAN|HGNC=8584|UniProtKB=P05120	Plasminogen activator inhibitor 2	RCA	14996729	PubMed	PTHR11461:SF61	PLASMINOGEN ACTIVATOR INHIBITOR 2
P06215	MYO signaling pathway	P06310	BABO	DROME|FlyBase=FBgn0011300|UniProtKB=A1Z7L8	Receptor protein serine/threonine kinase	IEA	9395284	PubMed	PTHR23255:SF71	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	YEAST|SGD=S000004690|UniProtKB=P0CF18	Uncharacterized protein YMR085W	ISS			PTHR10937:SF0	GH12731P-RELATED
P00047	PDGF signaling pathway	P01162	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	RCA	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00048	PI3 kinase pathway	P01179	PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01167	Ets	PANTR|Ensembl=ENSPTRG00000003497|UniProtKB=H2Q3E6	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF15	ETS-RELATED TRANSCRIPTION FACTOR ELF-5
P00049	Parkinson disease	P01242	Casein kinase I	MOUSE|MGI=MGI=1917675|UniProtKB=Q8C4X2	Casein kinase I isoform gamma-3	IDA	10617630	PubMed	PTHR11909:SF151	CASEIN KINASE I ISOFORM GAMMA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CAEEL|WormBase=WBGene00000066|UniProtKB=P10986	Actin-4	IC	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00035	Interferon-gamma signaling pathway	P00960	PTP	DANRE|ZFIN=ZDB-GENE-030131-5911|UniProtKB=F1QZU5	Tyrosine-protein phosphatase non-receptor type	ISS	8096088	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00021	FGF signaling pathway	P00633	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00010	B cell activation	P00368	vav	RAT|RGD=1306285|UniProtKB=D3ZYG0	Protein Vav2	ISS	14623913	PubMed	PTHR22826:SF95	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	IGI	11790551	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	DROME|FlyBase=FBgn0010051|UniProtKB=P29993	Inositol 1,4,5-trisphosphate receptor	IDA	4262086	gi	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	CANLF|Ensembl=ENSCAFG00000015662|UniProtKB=E2RHY4	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MONDO|Ensembl=ENSMODG00000000771|UniProtKB=F6SSS3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00021	FGF signaling pathway	P00629	PP2A	MOUSE|MGI=MGI=1321159|UniProtKB=P63330	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00046	Oxidative stress response	P01129	JNK1/2	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00059	p53 pathway	P04633	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	MOUSE|MGI=MGI=97578|UniProtKB=Q7TSH2	Phosphorylase b kinase regulatory subunit beta	ISS	10487978	PubMed	PTHR10749:SF8	PHOSPHORYLASE B KINASE REGULATORY SUBUNIT BETA
P00012	Cadherin signaling pathway	P00470	F-actin	DANRE|ZFIN=ZDB-GENE-000329-1|UniProtKB=Q7ZVI7	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00054	Toll receptor signaling pathway	P01348	A20	MOUSE|MGI=MGI=1196377|UniProtKB=Q60769	Tumor necrosis factor alpha-induced protein 3	ISS			PTHR13367:SF3	TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 3
P02746	Heme biosynthesis	P02973	Uroporphyrinogen methyltransferase	METAC|EnsemblGenome=MA_3033|UniProtKB=Q8TLK3	Uroporphyrin-III C-methyltransferase	ISS			PTHR21091:SF16	SIROHEME SYNTHASE
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	SCLS1|EnsemblGenome=SS1G_03482|UniProtKB=A7EDU2	Guanine nucleotide-binding protein beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00049	Parkinson disease	P01242	Casein kinase I	ORNAN|Ensembl=ENSOANG00000010562|UniProtKB=F6TBG4	Uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00012	Cadherin signaling pathway	P00470	F-actin	PANTR|Ensembl=ENSPTRG00000006890|UniProtKB=H2Q943	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00005	Angiogenesis	P00250	VE-PTP	HUMAN|HGNC=9665|UniProtKB=P23467	Receptor-type tyrosine-protein phosphatase beta	IDA	10557082	PubMed	PTHR19134:SF288	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE BETA
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000017343|UniProtKB=Q5DRD3	Protocadherin beta-15	ISS	8120095	PubMed	PTHR24028:SF97	PROTOCADHERIN BETA-15
P00006	Apoptosis signaling pathway	P00310	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02774	Salvage pyrimidine deoxyribonucleotides	P03147	Thymidine kinase	DEIRA|EnsemblGenome=DR_1984|UniProtKB=Q9RSY5	Thymidine kinase	ISS			PTHR11441:SF0	THYMIDINE KINASE, CYTOSOLIC
P00023	General transcription regulation	P00658	TBP-associated factors	MOUSE|MGI=MGI=1926879|UniProtKB=Q9EQH4	Transcription initiation factor TFIID subunit 8	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00009	Axon guidance mediated by netrin	P00364	cdc42	SCHPO|PomBase=SPAC110.03|UniProtKB=Q01112	Cell division control protein 42 homolog	ISS	12932731	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00054	Toll receptor signaling pathway	P01355	AP1	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00021	FGF signaling pathway	P00627	ERK1-2	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	ISS	12001934	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000002647|UniProtKB=F7DIB7	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=11433|UniProtKB=Q16623	Syntaxin-1A	ISS	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05918	p38 MAPK pathway	P06023	MEF	MACMU|Ensembl=ENSMMUG00000019836|UniProtKB=F7FUB3	Uncharacterized protein	ISS	11274345	PubMed	PTHR11945:SF25	MYOCYTE-SPECIFIC ENHANCER FACTOR 2C
P05917	Opioid proopiomelanocortin pathway	P06011	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00018	EGF receptor signaling pathway	P00565	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00035	Interferon-gamma signaling pathway	P00960	PTP	CHICK|Ensembl=ENSGALG00000004821|UniProtKB=Q90687	Tyrosine-protein phosphatase non-receptor type 11	TAS	14534538	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MOUSE|MGI=MGI=99842|UniProtKB=Q02284	5-hydroxytryptamine receptor 1F	ISS	12181435	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00017	DNA replication	P00534	PCNA	THEKO|EnsemblGenome=TK0535|UniProtKB=Q5JF32	DNA polymerase sliding clamp 1	ISS	20484199	PubMed	PTHR11352:SF0	PROLIFERATING CELL NUCLEAR ANTIGEN
P00046	Oxidative stress response	P01129	JNK1/2	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	TAS	97102675	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00224	PDGF	MOUSE|MGI=MGI=97528|UniProtKB=P31240	Platelet-derived growth factor subunit B	ISS			PTHR11633:SF2	PLATELET-DERIVED GROWTH FACTOR SUBUNIT B
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	HUMAN|HGNC=6081|UniProtKB=P01308	Insulin	ISS			PTHR11454:SF9	INSULIN-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	MACMU|Ensembl=ENSMMUG00000012305|UniProtKB=F7DLC9	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00012	Cadherin signaling pathway	P00465	TCF/LEF	RAT|RGD=620241|UniProtKB=Q9QXN1	Lymphoid enhancer-binding factor 1	ISS	11266476	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	RAT|RGD=69261|UniProtKB=O70512	Cytokine-inducible SH2-containing protein (Fragment)	ISS	15032587	PubMed	PTHR44649:SF1	CYTOKINE-INDUCIBLE SH2-CONTAINING PROTEIN
P00057	Wnt signaling pathway	P01471	alpha-catenin	DANRE|ZFIN=ZDB-GENE-991207-24|UniProtKB=Q9PVF8	Catenin (Cadherin-associated protein), alpha	IDA	1768802	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95808|UniProtKB=P23818	Glutamate receptor 1	ISS	12871085	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P02772	Pyruvate metabolism	P03137	Citrate Lyase	ECOLI|EcoGene=EG13542|UniProtKB=P0A9I1	Citrate lyase subunit beta	ISS			PTHR32308:SF0	CITRATE LYASE SUBUNIT BETA
P00029	Huntington disease	G01529	Proline oxidase	MOUSE|MGI=MGI=97770|UniProtKB=Q9WU79	Proline dehydrogenase 1, mitochondrial	NAS			PTHR13914:SF0	PROLINE DEHYDROGENASE 1, MITOCHONDRIAL
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	CAEBR|Gene=CBG06092|UniProtKB=A8X0X5	Protein CBR-LET-60	ISS	22022015	PubMed	PTHR24070:SF385	GTPASE HRAS
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	CAEEL|WormBase=WBGene00000900|UniProtKB=P50488	Cell surface receptor daf-4	TAS	9395284	PubMed	PTHR23255:SF70	SERINE/THREONINE-PROTEIN KINASE RECEPTOR
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	CHICK|Gene=ACVR2B|UniProtKB=Q90670	Activin receptor type-2B	TAS	11252892	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P05915	Opioid proenkephalin pathway	P05989	leu-Enkephalin	HUMAN|HGNC=8831|UniProtKB=P01210	Proenkephalin-A	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00034	Integrin signalling pathway	P00906	Rap1	BOVIN|Ensembl=ENSBTAG00000004131|UniProtKB=Q08DI5	Ras-related protein Rap-2c	ISS	8576107	PubMed	PTHR24070:SF200	RAS-RELATED PROTEIN RAP-2C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00009	Axon guidance mediated by netrin	P00366	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00005	Angiogenesis	P00240	FRS-2	BOVIN|Ensembl=ENSBTAG00000019155|UniProtKB=E1B7I9	Uncharacterized protein	ISS	12571252	PubMed	PTHR21258:SF40	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2
P02746	Heme biosynthesis	P02980	Coproporphyrinogen Oxidase (oxygen dependent)	MOUSE|MGI=MGI=104841|UniProtKB=P36552	Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial	ISS			PTHR10755:SF0	OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	DICDI|dictyBase=DDB_G0290263|UniProtKB=Q9XZE5	Serine/threonine-protein phosphatase 2A catalytic subunit A	ISS	10452519	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02736	Coenzyme A biosynthesis	P02883	Pantothenoylcysteine decarboxylase	LEPIN|EnsemblGenome=LA_3935|UniProtKB=Q8EZC0	DNA/pantothenate metabolism flavoprotein	ISS			PTHR14359:SF6	PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IDA	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PANTR|Ensembl=ENSPTRG00000002086|UniProtKB=H2Q1A9	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	MACMU|Ensembl=ENSMMUG00000003707|UniProtKB=F7GDQ6	Receptor protein serine/threonine kinase	ISS			PTHR23255:SF58	ACTIVIN RECEPTOR TYPE-1C
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00012	Cadherin signaling pathway	P00471	Cadherin	MONDO|Ensembl=ENSMODG00000004732|UniProtKB=F6Y191	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF322	CADHERIN-6
P00018	EGF receptor signaling pathway	P00565	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	BOVIN|Ensembl=ENSBTAG00000018691|UniProtKB=A5D7J5	Rho-related GTP-binding protein RhoU	ISS			PTHR24072:SF148	RHO-RELATED GTP-BINDING PROTEIN RHOU
P00036	Interleukin signaling pathway	P00983	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	CANLF|Ensembl=ENSCAFG00000028654|UniProtKB=J9P702	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00019	Endothelin signaling pathway	P00591	PLCbeta	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00049	Parkinson disease	P01212	p38 MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00644	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IGI	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	ARATH|TAIR=AT4G26520|UniProtKB=P22197	Fructose-bisphosphate aldolase, cytoplasmic isozyme	TAS	15236767	gi	PTHR11627:SF20	FRUCTOSE-BISPHOSPHATE ALDOLASE
P00012	Cadherin signaling pathway	P00470	F-actin	DANRE|ZFIN=ZDB-GENE-000329-3|UniProtKB=Q7ZVF9	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00036	Interleukin signaling pathway	P00973	PKB	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04570	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	MOUSE|MGI=MGI=1351339|UniProtKB=Q14BI2	Metabotropic glutamate receptor 2	ISS	9407094	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00056	VEGF signaling pathway	P01407	Erk	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	RAT|RGD=621669|UniProtKB=O88761	26S proteasome non-ATPase regulatory subunit 1	ISS			PTHR10943:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04452	proopiomelanocortin	HUMAN|HGNC=9201|UniProtKB=P01189	Pro-opiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	HUMAN|HGNC=4581|UniProtKB=Q13003	Glutamate receptor ionotropic, kainate 3	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CHICK|Ensembl=ENSGALG00000012511|UniProtKB=F1NCH1	Uncharacterized protein	ISS			PTHR11824:SF7	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4
P00001	Adrenaline and noradrenaline biosynthesis	P00062	TH	CHICK|Ensembl=ENSGALG00000006551|UniProtKB=F6RRW6	Uncharacterized protein	ISS	12814656	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	MONDO|Ensembl=ENSMODG00000018459|UniProtKB=F7CU42	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00021	FGF signaling pathway	P00629	PP2A	HUMAN|HGNC=9313|UniProtKB=Q16537	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	IDA	8703017	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P05918	p38 MAPK pathway	P06021	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12676940	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	11832947	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PLAF7|EnsemblGenome=PFL2215w|UniProtKB=Q8I4X0	Actin-1	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P06211	BMP/activin signaling pathway-drosophila	P06241	TGFbetaR I	DROME|FlyBase=FBgn0011300|UniProtKB=A1Z7L8	Receptor protein serine/threonine kinase	RCA	http://flybase.org/reports/FBgn0011300.html	Website	PTHR23255:SF71	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00005	Angiogenesis	P00184	Src	RAT|RGD=620795|UniProtKB=Q9WUD9	Proto-oncogene tyrosine-protein kinase Src	ISS	11078745	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00025	Hedgehog signaling pathway	P00682	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00573	signal peptidase	RAT|RGD=628665|UniProtKB=Q9WTR7	Signal peptidase complex catalytic subunit SEC11C	ISS	2092035	PubMed	PTHR10806:SF12	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11C
P04393	Ras Pathway	P04556	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MACMU|Ensembl=ENSMMUG00000014754|UniProtKB=F7G124	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF721	MYOSIN-6
P02734	Chorismate biosynthesis	P02872	3-Dehydroquinate synthase	SCHPO|PomBase=SPAC1834.02|UniProtKB=Q9P7R0	Pentafunctional AROM polypeptide	ISS			PTHR21090:SF5	PENTAFUNCTIONAL AROM POLYPEPTIDE
P00057	Wnt signaling pathway	P01451	Galpha	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	IDA	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00029	Huntington disease	P00774	Dynein complex	PANTR|Ensembl=ENSPTRG00000007854|UniProtKB=H2QAQ0	Uncharacterized protein	ISS	9454836	PubMed	PTHR10676:SF242	DYNEIN HEAVY CHAIN 3, AXONEMAL
P00005	Angiogenesis	P00183	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00006	Apoptosis signaling pathway	P00305	Caspase 3	MACMU|Ensembl=ENSMMUG00000012053|UniProtKB=F7HFY2	Uncharacterized protein	ISS	11675509	PubMed	PTHR10454:SF198	CASPASE-3
P00057	Wnt signaling pathway	P01428	Frizzled	CANLF|Ensembl=ENSCAFG00000013159|UniProtKB=E2RAF3	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF79	FRIZZLED-9
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	ISS	97320448	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P06959	CCKR signaling map	P07182	Pro HBEGF	HUMAN|HGNC=3059|UniProtKB=Q99075	Proheparin-binding EGF-like growth factor	RCA	9869605	PubMed	PTHR10740:SF4	PROHEPARIN-BINDING EGF-LIKE GROWTH FACTOR
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00236	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00010	B cell activation	P00402	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00269	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06959	CCKR signaling map	G07271	CHGA	HUMAN|HGNC=1929|UniProtKB=P10645	Chromogranin-A	RCA	17889508	PubMed	PTHR10583:SF1	CHROMOGRANIN-A
P00019	Endothelin signaling pathway	P00590	IP3 R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	8387895	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00019	Endothelin signaling pathway	P00568	PKC	SCHPO|PomBase=SPAC17G8.14c|UniProtKB=P36582	Protein kinase C-like 1	IGI	93259141	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	IDA	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	RAT|RGD=2847|UniProtKB=P28565	5-hydroxytryptamine receptor 1D	IEA	11701344	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P04398	p53 pathway feedback loops 2	P04654	Rb	RAT|RGD=1595511|UniProtKB=D3ZS28	Protein Rbl1	ISS			PTHR13742:SF20	RETINOBLASTOMA-LIKE PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00029	Huntington disease	P00787	MAPKK4	MONDO|Ensembl=ENSMODG00000008266|UniProtKB=F6Z879	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00192	PAR	RAT|RGD=2586|UniProtKB=P26824	Proteinase-activated receptor 1	RCA			PTHR24232:SF20	PROTEINASE-ACTIVATED RECEPTOR 1
P00025	Hedgehog signaling pathway	P00686	Fused	MACMU|Ensembl=ENSMMUG00000006744|UniProtKB=F7HD33	Uncharacterized protein	ISS			PTHR22983:SF6	SERINE/THREONINE-PROTEIN KINASE 36
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MOUSE|MGI=MGI=87906|UniProtKB=P63260	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00048	PI3 kinase pathway	P01182	Ras	SCHPO|PomBase=SPAC17H9.09c|UniProtKB=P08647	Ras-like protein 1	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00006	Apoptosis signaling pathway	P00269	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00049	Parkinson disease	P01233	Elk-1	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	10487205	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	DANRE|ZFIN=ZDB-GENE-020125-4|UniProtKB=F1QKT1	Uncharacterized protein	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P04396	Vitamin D metabolism and pathway	P04608	24-Hydroxylase	HUMAN|HGNC=2602|UniProtKB=Q07973	1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	IDA	11686044	PubMed	PTHR24291:SF5	1,25-DIHYDROXYVITAMIN D 3  24-HYDROXYLASE, MITOCHONDRIAL
P00034	Integrin signalling pathway	P00912	Arp2/3	DROME|FlyBase=FBgn0031437|UniProtKB=Q9VQD8	Actin-related protein 2/3 complex subunit 5	IPI	12473693	PubMed	PTHR12644:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00562	p38	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	IGI	20451058	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DAPPU|EnsemblGenome=DAPPUDRAFT_228751|UniProtKB=E9HGF5	Cytoplasmatic actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05730	Endogenous cannabinoid signaling	P05746	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	IDA	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04398	p53 pathway feedback loops 2	P04665	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00628	JNK1-3	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	MACMU|Ensembl=ENSMMUG00000004886|UniProtKB=F7AGT9	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CANLF|Ensembl=ENSCAFG00000012623|UniProtKB=F1PVP1	Uncharacterized protein	ISS	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00010	B cell activation	P00373	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00566	ERK	ORYSJ|EnsemblGenome=OS02G0148100|UniProtKB=Q6Z437	Mitogen-activated protein kinase 3	ISS			PTHR24055:SF216	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00036	Interleukin signaling pathway	P00995	c-Myc	MOUSE|MGI=MGI=97250|UniProtKB=P01108	Myc proto-oncogene protein	ISS	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	MACMU|Ensembl=ENSMMUG00000017022|UniProtKB=F7HQZ9	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00046	Oxidative stress response	P01129	JNK1/2	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	ORNAN|Ensembl=ENSOANG00000002138|UniProtKB=F6SV12	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF26	MATRIX METALLOPROTEINASE-16
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00006	Apoptosis signaling pathway	P00289	FAS	HUMAN|HGNC=11920|UniProtKB=P25445	Tumor necrosis factor receptor superfamily member 6	IDA	14585074	PubMed	PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P00021	FGF signaling pathway	P00632	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	PANTR|Ensembl=ENSPTRG00000007711|UniProtKB=H2QAH4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF319	ADENYLATE CYCLASE TYPE 9
P00057	Wnt signaling pathway	P01435	SWI/SNF	HUMAN|HGNC=11104|UniProtKB=Q92922	SWI/SNF complex subunit SMARCC1	IDA	11532957	PubMed	PTHR12802:SF9	SWI/SNF COMPLEX SUBUNIT SMARCC1
P00010	B cell activation	P00383	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00807	Actin	TAKRU|Ensembl=ENSTRUG00000005447|UniProtKB=P68142	Actin, cytoplasmic 1	IDA	11889126	PubMed	PTHR11937:SF354	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	HUMAN|HGNC=7578|UniProtKB=P13535	Myosin-8	IEP	89264452	PubMed	PTHR13140:SF368	MYOSIN-8
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01471	alpha-catenin	BOVIN|Gene=CTNNA1|UniProtKB=Q3MHM6	Catenin alpha-1	ISS	1904011	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00053	T cell activation	P01316	MHC-antigen	MACMU|Ensembl=ENSMMUG00000015734|UniProtKB=F6S7S7	Uncharacterized protein	ISS	73139	PubMed	PTHR19944:SF44	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DO ALPHA CHAIN
P00004	Alzheimer disease-presenilin pathway	P00123	CD44 C-terminal fragment	HUMAN|HGNC=1681|UniProtKB=P16070	CD44 antigen	IDA	14871815	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00010	B cell activation	P00367	NFAT	HUMAN|HGNC=7777|UniProtKB=Q12968	Nuclear factor of activated T-cells, cytoplasmic 3	IDA	12015605	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	PANTR|Ensembl=ENSPTRG00000000843|UniProtKB=H2QZN8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00047	PDGF signaling pathway	P01168	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00951	Jnk	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00010	B cell activation	P00381	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	BOVIN|Ensembl=ENSBTAG00000017894|UniProtKB=F1MVC0	Uncharacterized protein	ISS			PTHR11405:SF5	CAD PROTEIN
P00057	Wnt signaling pathway	P01454	betaTrCP	ORNAN|Ensembl=ENSOANG00000007791|UniProtKB=F6YUQ2	Uncharacterized protein	ISS	10074433	PubMed	PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00009	Axon guidance mediated by netrin	P00366	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	MACMU|Ensembl=ENSMMUG00000017022|UniProtKB=F7HQZ9	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	DICDI|dictyBase=DDB_G0283537|UniProtKB=P32254	Ras-like protein rasS	ISS	8290260	PubMed	PTHR24070:SF380	RAS-LIKE PROTEIN RASS
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00010	B cell activation	P00386	Calcineurin	CANLF|Ensembl=ENSCAFG00000010644|UniProtKB=F2Z4P5	Serine/threonine-protein phosphatase	ISS	7532676	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00544	c-Cbl	MOUSE|MGI=MGI=1931457|UniProtKB=Q80XL1	E3 ubiquitin-protein ligase CBL-C	ISS	12845517	gi	PTHR23007:SF12	E3 UBIQUITIN-PROTEIN LIGASE CBL-C
P00019	Endothelin signaling pathway	P00572	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04393	Ras Pathway	P04559	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	RAT|RGD=621060|UniProtKB=O88777	Presenilin-2	IDA	9332390	PubMed	PTHR10202:SF13	PRESENILIN-2
P00034	Integrin signalling pathway	P00936	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IPI	14526383	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IC	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00021	FGF signaling pathway	P00643	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	XENTR|Xenbase=XB-GENE-480551|UniProtKB=F6XVE6	Uncharacterized protein (Fragment)	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01202	p85	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00036	Interleukin signaling pathway	P00975	RasGAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	ISS	8262392	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Gene=HTR1F|UniProtKB=Q9N2D9	5-hydroxytryptamine receptor 1F (Fragment)	IDA	11701344	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P04393	Ras Pathway	P04561	SRF	MACMU|Ensembl=ENSMMUG00000000033|UniProtKB=F7G4D2	Uncharacterized protein	ISS	15170389	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00053	T cell activation	P01322	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00474	Wnt	BOVIN|Gene=WNT16|UniProtKB=Q5E9U6	Protein Wnt-16	ISS	8717036	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P00021	FGF signaling pathway	P00634	MEKK1-5	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	IDA	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00053	T cell activation	P01302	CD3 eta	MOUSE|MGI=MGI=88332|UniProtKB=P22646	T-cell surface glycoprotein CD3 epsilon chain	IGI	9886373	PubMed	PTHR10570:SF9	T-CELL SURFACE GLYCOPROTEIN CD3 EPSILON CHAIN
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00573	signal peptidase	MACMU|Ensembl=ENSMMUG00000004408|UniProtKB=F7GUB4	Signal peptidase complex catalytic subunit SEC11	ISS	2674115	PubMed	PTHR10806:SF12	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11C
P00057	Wnt signaling pathway	P01438	PP2A	MONDO|Ensembl=ENSMODG00000014177|UniProtKB=F6U7A6	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00059	p53 pathway	P01486	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01238	14-3-3	ENTHI|EnsemblGenome=EHI_025360|UniProtKB=C4M323	14-3-3 protein 1	IDA	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000002603|UniProtKB=H2RC60	Uncharacterized protein	ISS	8120095	PubMed	PTHR43956:SF3	CADHERIN-23
P00021	FGF signaling pathway	P00629	PP2A	MOUSE|MGI=MGI=1920180|UniProtKB=Q6ZWR4	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform	ISS	1849734	PubMed	PTHR11871:SF1	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	RAT|RGD=620761|UniProtKB=Q9R172	Neurogenic locus notch homolog protein 3	IDA	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00034	Integrin signalling pathway	P00924	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_126324|UniProtKB=C3XYC2	Putative uncharacterized protein	IDA	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05918	p38 MAPK pathway	P06031	p38alpha	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04397	p53 pathway by glucose deprivation	P04640	p53	HUMAN|HGNC=11998|UniProtKB=P04637	Cellular tumor antigen p53	TAS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	NEUCR|EnsemblGenome=EFNCRG00000008511|UniProtKB=V5IKK0	Syntaxin family protein	IC			PTHR19957:SF147	SUBFAMILY NOT NAMED
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	BOVIN|Gene=HRH1|UniProtKB=P30546	Histamine H1 receptor	IDA			PTHR43914:SF2	HISTAMINE H1 RECEPTOR
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	15621031	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00054	Toll receptor signaling pathway	P01352	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	ARATH|TAIR=AT3G12980|UniProtKB=Q9LE42	Histone acetyltransferase HAC5	TAS	10664585	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P04393	Ras Pathway	P04567	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02759	Pyridoxal-5-phosphate biosynthesis	P03062	1-Deoxyxylulose-5-phosphate synthase	MYCTU|EnsemblGenome=Rv2682c|UniProtKB=P9WNS3	1-deoxy-D-xylulose-5-phosphate synthase	ISS			PTHR43322:SF6	1-DEOXY-D-XYLULOSE-5-PHOSPHATE SYNTHASE
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	PANTR|Gene=DRD2|UniProtKB=P60026	D(2) dopamine receptor	ISS	2137198	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00011	Blood coagulation	P00406	Fibrinogen	RAT|RGD=2604|UniProtKB=P14480	Fibrinogen beta chain	ISS	1706801	gi	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	HUMAN|HGNC=6697|UniProtKB=O75197	Low-density lipoprotein receptor-related protein 5	IDA	11907044	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00029	Huntington disease	P00780	Microtubule	STRPU|EnsemblGenome=SPU_002788|UniProtKB=W4XHC0	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00030	Hypoxia response via HIF activation	P00819	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IPI	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00034	Integrin signalling pathway	P00948	Rho	ASHGO|EnsemblGenome=AGOS_ACR257C|UniProtKB=Q9P8V0	GTP-binding protein RHO4	ISS	11973360	PubMed	PTHR24072:SF258	GTP-BINDING PROTEIN RHO4
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DICDI|dictyBase=DDB_G0268744|UniProtKB=Q55EU6	Putative actin-23	IC	11889126	PubMed	PTHR11937:SF154	ACTIN-17-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	XENTR|Xenbase=XB-GENE-491938|UniProtKB=Q6DIV8	Actin, alpha 1, skeletal muscle	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347736|UniProtKB=E9FRT1	Muscle-specific actin	ISS	11889126	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P04393	Ras Pathway	P04560	AP1	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P05915	Opioid proenkephalin pathway	P05994	G-protein	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	CANLF|Ensembl=ENSCAFG00000000760|UniProtKB=E2R9L4	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00054	Toll receptor signaling pathway	P01381	Ubc13	HUMAN|HGNC=31710|UniProtKB=Q5JXB2	Putative ubiquitin-conjugating enzyme E2 N-like	ISS			PTHR43902:SF3	UBIQUITIN-CONJUGATING ENZYME E2 N-LIKE-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Ensembl=ENSBTAG00000007635|UniProtKB=F1MLS3	Phosphoinositide phospholipase C	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P00025	Hedgehog signaling pathway	P00682	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00060	Ubiquitin proteasome pathway	P01491	E2	DROME|FlyBase=FBgn0017456|UniProtKB=P52487	Ubiquitin-conjugating enzyme E2-18 kDa	ISS	11078524	PubMed	PTHR24068:SF116	AT26201P-RELATED
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MACMU|Ensembl=ENSMMUG00000019973|UniProtKB=F7FSP4	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF38	GROWTH/DIFFERENTIATION FACTOR 3
P00006	Apoptosis signaling pathway	P00260	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IGI	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00628	JNK1-3	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00552	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00021	FGF signaling pathway	P00643	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00545	JNK1-3	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00640	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IGI	7937853	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P05915	Opioid proenkephalin pathway	P05995	proenkephalin	DANRE|ZFIN=ZDB-GENE-030729-3|UniProtKB=F1QTD1	Uncharacterized protein (Fragment)	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P04391	Oxytocin receptor mediated signaling pathway	P04531	Oxytocin Receptor	PANTR|Ensembl=ENSPTRG00000014582|UniProtKB=H2QM02	Oxytocin receptor	ISS	11006161	PubMed	PTHR24241:SF19	OXYTOCIN RECEPTOR
P06664	Gonadotropin-releasing hormone receptor pathway	P06841	gnaq/11	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	RCA	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	ARATH|TAIR=AT4G38470|UniProtKB=F4JTP5	Serine/threonine-protein kinase STY46	ISS			PTHR44012:SF1	SERINE/THREONINE-PROTEIN KINASE STY46
P00018	EGF receptor signaling pathway	P00541	Spry	MACMU|Ensembl=ENSMMUG00000014175|UniProtKB=F7ALK4	Uncharacterized protein	ISS	10330503	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P02727	Androgen/estrogene/progesterone biosynthesis	P02830	Cholesterol esterase	HUMAN|HGNC=6617|UniProtKB=P38571	Lysosomal acid lipase/cholesteryl ester hydrolase	IMP	8146180	PubMed	PTHR11005:SF26	LYSOSOMAL ACID LIPASE/CHOLESTERYL ESTER HYDROLASE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00056	VEGF signaling pathway	P01411	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P06664	Gonadotropin-releasing hormone receptor pathway	P06786	ERK1/2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	RCA	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04552	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	PANTR|Ensembl=ENSPTRG00000004207|UniProtKB=H2Q4M0	Uncharacterized protein	ISS	11055438	PubMed	PTHR10117:SF7	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 6
P00004	Alzheimer disease-presenilin pathway	P00113	Erb-B4 transmembrane fragment	PANTR|Ensembl=ENSPTRG00000012883|UniProtKB=H2QJC5	Receptor protein-tyrosine kinase	ISS	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00036	Interleukin signaling pathway	P00977	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MACMU|Ensembl=ENSMMUG00000017683|UniProtKB=F6UA63	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00056	VEGF signaling pathway	P01407	Erk	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01315	Calcineurin	ORNAN|Ensembl=ENSOANG00000010781|UniProtKB=F6X434	Serine/threonine-protein phosphatase	ISS	12015605	PubMed	PTHR11668:SF186	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT GAMMA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_115566|UniProtKB=C3XYC8	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01152	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	11847220	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00057	Wnt signaling pathway	P01451	Galpha	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	ORYSJ|EnsemblGenome=OS01G0267900|UniProtKB=Q0JNS6	Calmodulin-1	ISS	3885394	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	TAS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00052	TGF-beta signaling pathway	P01284	JNK	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04398	p53 pathway feedback loops 2	P04660	SIAH-1	PANTR|Ensembl=ENSPTRG00000008094|UniProtKB=H2QB23	E3 ubiquitin-protein ligase	ISS	11389839	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	MONDO|Ensembl=ENSMODG00000019823|UniProtKB=F6SB23	Uncharacterized protein (Fragment)	ISS	96032356	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P06959	CCKR signaling map	P07045	CCK-33	HUMAN|HGNC=1569|UniProtKB=P06307	Cholecystokinin	RCA		PubMed	PTHR10786:SF0	CHOLECYSTOKININ
P00053	T cell activation	P01304	Csk	BOVIN|Ensembl=ENSBTAG00000021424|UniProtKB=Q0VBZ0	Tyrosine-protein kinase CSK	ISS	12665526	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00047	PDGF signaling pathway	P01168	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	10799299	PubMed	PTHR10048:SF14	PI-3 KINASE
P00052	TGF-beta signaling pathway	P01275	P38	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	TAS	8920915	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01411	Ras	CAEBR|Gene=CBG06092|UniProtKB=A8X0X5	Protein CBR-LET-60	ISS	22022015	PubMed	PTHR24070:SF385	GTPASE HRAS
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P06959	CCKR signaling map	P07190	G34	HUMAN|HGNC=4164|UniProtKB=P01350	Gastrin	RCA	9074765	PubMed	PTHR19309:SF0	GASTRIN
P00030	Hypoxia response via HIF activation	P00823	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01422	eNOS	PANTR|Ensembl=ENSPTRG00000019868|UniProtKB=H2QVM2	Nitric oxide synthase	ISS	22462730	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00057	Wnt signaling pathway	P01457	GBeta	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00046	Oxidative stress response	P01131	MKP5	MACMU|Ensembl=ENSMMUG00000022318|UniProtKB=F6XDK0	Uncharacterized protein	ISS			PTHR10159:SF402	DUAL SPECIFICITY PROTEIN PHOSPHATASE 19
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05913	Enkephalin release	P05976	Enkephalin	BOVIN|Gene=PDYN|UniProtKB=Q95104	Proenkephalin-B	ISS	131330	OMIM	PTHR11438:SF4	PROENKEPHALIN-B
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00012	Cadherin signaling pathway	P00470	F-actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347740|UniProtKB=E9FXV8	Cytoplasmatic actin	ISS	11889126	PubMed	PTHR11937:SF277	SUBFAMILY NOT NAMED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MONDO|Ensembl=ENSMODG00000004799|UniProtKB=F6VM87	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MONDO|Ensembl=ENSMODG00000023429|UniProtKB=F6XI83	Uncharacterized protein	ISS	1608964	PubMed	PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P05731	GABA-B receptor II signaling	P05754	Ggamma	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	RCA	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	RAT|RGD=620351|UniProtKB=P18265	Glycogen synthase kinase-3 alpha	IDA	12086949	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	BOVIN|Ensembl=ENSBTAG00000001137|UniProtKB=P04973	Clathrin light chain A	IDA	9388255	PubMed	PTHR10639:SF1	CLATHRIN LIGHT CHAIN A
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	11956331	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00047	PDGF signaling pathway	P01153	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00021	FGF signaling pathway	P00634	MEKK1-5	MONDO|Ensembl=ENSMODG00000006594|UniProtKB=F7AKA6	Uncharacterized protein	ISS	602425	OMIM	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	MOUSE|MGI=MGI=1351343|UniProtKB=Q5NCH9	Metabotropic glutamate receptor 6	ISS	9407094	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P02766	Phenylethylamine degradation	P03103	Phenylethylamine oxidase	BOVIN|Ensembl=ENSBTAG00000001041|UniProtKB=Q29437	Primary amine oxidase, liver isozyme	ISS			PTHR10638:SF23	MEMBRANE PRIMARY AMINE OXIDASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	RAT|RGD=3569|UniProtKB=P49801	Regulator of G-protein signaling 6 (Fragment)	ISS	8756726	PubMed	PTHR10845:SF27	REGULATOR OF G-PROTEIN SIGNALING 6
P00049	Parkinson disease	P01207	PLD2	RAT|RGD=3350|UniProtKB=P70498	Phospholipase D2	IDA	9538008	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00251	cPLA2	CANLF|Ensembl=ENSCAFG00000013778|UniProtKB=F6UQ33	Phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MONDO|Ensembl=ENSMODG00000008086|UniProtKB=F6YJ34	Ribosomal protein S6 kinase	ISS	10558991	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00013	Cell cycle	P00481	APC	MOUSE|MGI=MGI=2139135|UniProtKB=Q8BZQ7	Anaphase-promoting complex subunit 2	ISS	7019327	gi	PTHR11932:SF5	ANAPHASE-PROMOTING COMPLEX SUBUNIT 2
P05913	Enkephalin release	P05974	G-Protein (i)	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00048	PI3 kinase pathway	P01199	Galpha	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00034	Integrin signalling pathway	P00907	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	TAS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	MONDO|Ensembl=ENSMODG00000007323|UniProtKB=F7EFD0	Uncharacterized protein	ISS	8576107	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00048	PI3 kinase pathway	P01177	P110ACT	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	XENTR|Xenbase=XB-GENE-1012455|UniProtKB=F6TKH3	Uncharacterized protein (Fragment)	ISS			PTHR11824:SF7	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4
P00047	PDGF signaling pathway	P01173	STAT	MOUSE|MGI=MGI=103036|UniProtKB=P42230	Signal transducer and activator of transcription 5A	ISS	22320921	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	EMENI|EnsemblGenome=CADANIAG00006684|UniProtKB=G5EB66	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00047	PDGF signaling pathway	P01154	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00047	PDGF signaling pathway	P01160	IP3 receptor	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	YEAST|SGD=S000005767|UniProtKB=Q08645	Folylpolyglutamate synthase	ISS			PTHR11136:SF5	FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL
P00056	VEGF signaling pathway	P01417	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PHYPA|Gene=PHYPADRAFT_165677|UniProtKB=Q6TYR3	Beta-tubulin 5	ISS	9454836	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01444	Wnt	MACMU|Ensembl=ENSMMUG00000009980|UniProtKB=F6R3A1	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00052	TGF-beta signaling pathway	P01286	TGFbeta	DANRE|ZFIN=ZDB-GENE-990415-2|UniProtKB=B0S7E0	Inhibin, beta B	TAS	11451570	PubMed	PTHR11848:SF233	INHIBIN, BETA B
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	PANTR|Ensembl=ENSPTRG00000000387|UniProtKB=H2PYE3	Ribosomal protein S6 kinase	ISS	12213813	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P04392	P53 pathway feedback loops 1	P04537	p73DeltaN	ORNAN|Ensembl=ENSOANG00000013795|UniProtKB=F7DUR2	Uncharacterized protein (Fragment)	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04665	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00948	Rho	HUMAN|HGNC=668|UniProtKB=P62745	Rho-related GTP-binding protein RhoB	ISS	13679859	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00005	Angiogenesis	P00225	MEK	RAT|RGD=62087|UniProtKB=P27704	Mitogen-activated protein kinase 6	ISS			PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P04398	p53 pathway feedback loops 2	P04661	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00551	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IGI	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02786	Vitamin B6 biosynthesis	P03225	1-Deoxyxylulose-5-phosphate synthase	FUSNN|EnsemblGenome=FN1208|UniProtKB=Q8R639	1-deoxy-D-xylulose-5-phosphate synthase	ISS			PTHR43322:SF6	1-DEOXY-D-XYLULOSE-5-PHOSPHATE SYNTHASE
P00050	Plasminogen activating cascade	P01262	pro-uPA	PANTR|Ensembl=ENSPTRG00000002646|UniProtKB=H2Q245	Uncharacterized protein	ISS	137114	gi	PTHR24264:SF38	UROKINASE-TYPE PLASMINOGEN ACTIVATOR
P00053	T cell activation	P01311	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IDA	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00587	Raf-1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IDA	8787761	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00790	beta-Tubulin	MACMU|Ensembl=ENSMMUG00000012164|UniProtKB=F7GW57	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00005	Angiogenesis	P00203	Erk	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04376	5HT4 type receptor mediated signaling pathway	P04427	5HT4 Receptor	CHICK|Ensembl=ENSGALG00000001383|UniProtKB=F1NJL4	Uncharacterized protein	ISS	15118808	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P00021	FGF signaling pathway	P00627	ERK1-2	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=62087|UniProtKB=P27704	Mitogen-activated protein kinase 6	ISS	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	RAT|RGD=2523|UniProtKB=P25115	D(1B) dopamine receptor	ISS	9700720	PubMed	PTHR43893:SF8	D 1B  DOPAMINE RECEPTOR
P00011	Blood coagulation	P00458	GP IIIa	CHICK|Ensembl=ENSGALG00000000379|UniProtKB=Q92071	Integrin beta	ISS	631019	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=1261811|UniProtKB=Q9QZZ4	Unconventional myosin-XV	IC			PTHR13140:SF379	UNCONVENTIONAL MYOSIN-XV
P00049	Parkinson disease	P01208	Hsp70	TRIVA|Gene=TVAG_163000|UniProtKB=A2DFX7	Cytosolic heat shock protein 70, putative	IDA	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P02785	Valine biosynthesis	P03216	Acetolactate synthase	HUMAN|HGNC=6041|UniProtKB=A1L0T0	Acetolactate synthase-like protein	ISS			PTHR18968:SF155	ACETOLACTATE SYNTHASE-LIKE PROTEIN
P00010	B cell activation	P00381	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00392	I kappa B	MOUSE|MGI=MGI=1340031|UniProtKB=O88995	NF-kappa-B inhibitor-like protein 1	ISS	10811867	PubMed	PTHR15263:SF1	NF-KAPPA-B INHIBITOR-LIKE PROTEIN 1
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8676|UniProtKB=Q9H158	Protocadherin alpha-C1	IDA	8120095	PubMed	PTHR24028:SF153	PROTOCADHERIN ALPHA-C1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	DAPPU|EnsemblGenome=DAPPUDRAFT_305638|UniProtKB=E9FWY0	Putative uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF252	BETA-TUBULIN AT 97EF, ISOFORM B
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	TAS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	ARATH|TAIR=AT1G53510|UniProtKB=Q9C5C0	Mitogen-activated protein kinase 18	TAS			PTHR24055:SF200	MITOGEN-ACTIVATED PROTEIN KINASE 18-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00012	Cadherin signaling pathway	P00462	Casein kinase II	MOUSE|MGI=MGI=88548|UniProtKB=P67871	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00508	Cofilin	RAT|RGD=69285|UniProtKB=P45592	Cofilin-1	ISS			PTHR11913:SF17	COFILIN-1
P00020	FAS signaling pathway	P00614	ASK1	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS			PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P02723	Adenine and hypoxanthine salvage pathway	P02811	Adenosine deaminase	STRCO|EnsemblGenome=CAB66224|UniProtKB=Q9RDE5	Adenine deaminase	ISS			PTHR43114:SF2	ADENINE DEAMINASE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00989	Ets	BOVIN|Ensembl=ENSBTAG00000021709|UniProtKB=E1BJR2	Uncharacterized protein	ISS	8970723	PubMed	PTHR11849:SF16	TRANSCRIPTION FACTOR PU.1
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	PANTR|Ensembl=ENSPTRG00000018624|UniProtKB=A6H914	TATA box binding protein-like 1	ISS	10082669	PubMed	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00049	Parkinson disease	P01208	Hsp70	ARATH|TAIR=AT5G42020|UniProtKB=Q39043	Mediator of RNA polymerase II transcription subunit 37f	IDA	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00049	Parkinson disease	P01230	Src kinase	MACMU|Ensembl=ENSMMUG00000014635|UniProtKB=F7G2C9	Tyrosine-protein kinase	ISS	11162638	PubMed	PTHR24418:SF296	TYROSINE-PROTEIN KINASE FRK
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PANTR|Ensembl=ENSPTRG00000018890|UniProtKB=Q5R1X3	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	RAT|RGD=621005|UniProtKB=Q08849	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IGI	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00227	PLA2	CHICK|Ensembl=ENSGALG00000005065|UniProtKB=P49147	Cytosolic phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=12781|UniProtKB=Q93097	Protein Wnt-2b	IDA	11266476	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00047	PDGF signaling pathway	P01159	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00048	PI3 kinase pathway	P01206	14-3-3	XENTR|Xenbase=XB-GENE-970616|UniProtKB=Q6P4Z5	14-3-3 protein zeta	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	HUMAN|HGNC=10935|UniProtKB=Q05940	Synaptic vesicular amine transporter	ISS	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CAEEL|WormBase=WBGene00001187|UniProtKB=Q8MQA1	Uncharacterized protein	IC	10514528	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	ISS	94280860	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04395	Vasopressin synthesis	P04594	Neurophysin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DROME|FlyBase=FBgn0030011|UniProtKB=Q9W3J1	Gbeta5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00047	PDGF signaling pathway	P01148	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8235613	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00034	Integrin signalling pathway	P00947	Laminin	CAEEL|WormBase=WBGene00002248|UniProtKB=G5ECE3	LAMinin related. See also lmb	IPI	2538453	PubMed	PTHR10574:SF362	LAMININ RELATED. SEE ALSO LMB
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8708|UniProtKB=Q9Y5G3	Protocadherin gamma-B1	IDA	8120095	PubMed	PTHR24028:SF106	PROTOCADHERIN GAMMA-B1-RELATED
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00034	Integrin signalling pathway	P00920	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04393	Ras Pathway	P04561	SRF	MOUSE|MGI=MGI=106658|UniProtKB=Q9JM73	Serum response factor	IDA	15647354	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=107469|UniProtKB=Q8K3R3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	TAS			PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00057	Wnt signaling pathway	P01457	GBeta	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00019	Endothelin signaling pathway	P00590	IP3 R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00019	Endothelin signaling pathway	P00575	furin	DROME|FlyBase=FBgn0004509|UniProtKB=P26016	Furin-like protease 1, isoforms 1/1-X/2	ISS	7737999	PubMed	PTHR42884:SF3	FURIN-LIKE PROTEASE 1, ISOFORMS 1/1-X/2
P00004	Alzheimer disease-presenilin pathway	P00148	Erb-B4 N-terminal fragment	MACMU|Ensembl=ENSMMUG00000001674|UniProtKB=F7G3H1	Receptor protein-tyrosine kinase	ISS	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04395	Vasopressin synthesis	P04593	Glycopeptide	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	IC	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	DANRE|ZFIN=ZDB-GENE-991119-4|UniProtKB=Q9W6T7	Presenilin-1	IDA	12101103	PubMed	PTHR10202:SF18	PRESENILIN-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PHYPA|Gene=PHYPADRAFT_213086|UniProtKB=A9SJR1	Beta-tubulin 4	ISS	12932731	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00269	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=98961|UniProtKB=P24383	Protein Wnt-7a	IDA	12549854	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00050	Plasminogen activating cascade	P01258	Fibrin C-terminal truncation	HUMAN|HGNC=3661|UniProtKB=P02671	Fibrinogen alpha chain	ISS	6575700	PubMed	PTHR19143:SF232	FIBRINOGEN ALPHA CHAIN
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	IDA	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	MONDO|Ensembl=ENSMODG00000018065|UniProtKB=F7G485	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00048	PI3 kinase pathway	P01188	Gbetagamma	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05915	Opioid proenkephalin pathway	P05994	G-protein	DROME|FlyBase=FBgn0001105|UniProtKB=P26308	Guanine nucleotide-binding protein subunit beta-1	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00049	Parkinson disease	P01233	Elk-1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	IDA	14670631	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	4757952	gi	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00059	p53 pathway	G04702	p53	RAT|RGD=620863|UniProtKB=Q9JJP6	Tumor protein 63	TAS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	IC	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MOUSE|MGI=MGI=2152453|UniProtKB=Q2NL51	Glycogen synthase kinase-3 alpha	ISS	11995474	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00005	Angiogenesis	P00188	Ets	MACMU|Ensembl=ENSMMUG00000020706|UniProtKB=F6PU72	Uncharacterized protein	ISS	15699632	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	STRPU|EnsemblGenome=SPU_018419|UniProtKB=W4YRI6	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	IDA	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=1307370|UniProtKB=F1M7E5	Protein Cdh5	ISS	8120095	PubMed	PTHR24027:SF89	CADHERIN-5
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P05731	GABA-B receptor II signaling	P05754	Ggamma	PANTR|Ensembl=ENSPTRG00000019407|UniProtKB=H2QUY0	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MACMU|Ensembl=ENSMMUG00000023736|UniProtKB=F7G778	Uncharacterized protein	ISS	18005395	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P00005	Angiogenesis	P00182	p38MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00053	T cell activation	P01320	PLC-gamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	IC	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00542	EGFR	BOVIN|Ensembl=ENSBTAG00000021798|UniProtKB=F1MCQ7	Receptor protein-tyrosine kinase	ISS	2575867	gi	PTHR24416:SF137	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2
P00029	Huntington disease	P00805	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00025	Hedgehog signaling pathway	P00692	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MONDO|Ensembl=ENSMODG00000020204|UniProtKB=F6SED9	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00021	FGF signaling pathway	P00640	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00586	Gq	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00005	Angiogenesis	P00227	PLA2	MONDO|Ensembl=ENSMODG00000011791|UniProtKB=F7CBU9	Phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05938	RhoA	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	ISS	11360179	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00034	Integrin signalling pathway	P00948	Rho	MOUSE|MGI=MGI=107949|UniProtKB=P62746	Rho-related GTP-binding protein RhoB	ISS	11973360	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	HUMAN|HGNC=15472|UniProtKB=O94788	Retinal dehydrogenase 2	IC	14724059	PubMed	PTHR11699:SF102	RETINAL DEHYDROGENASE 2
P00059	p53 pathway	P01481	ATM/ATR	MOUSE|MGI=MGI=107202|UniProtKB=Q62388	Serine-protein kinase ATM	ISS			PTHR11139:SF72	SERINE-PROTEIN KINASE ATM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	TAKRU|Ensembl=ENSTRUG00000010022|UniProtKB=H2TKL1	Actin-related protein 2/3 complex subunit 4	ISS	9230079	PubMed	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00558	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00034	Integrin signalling pathway	P00940	Src	MOUSE|MGI=MGI=103265|UniProtKB=Q922K9	Tyrosine-protein kinase FRK	IPI	8054685	PubMed	PTHR24418:SF296	TYROSINE-PROTEIN KINASE FRK
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00053	T cell activation	P01335	jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IPI	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02726	Aminobutyrate degradation	P02824	Succinate semi-aldehyde dehydrogenase	ARATH|TAIR=AT1G79440|UniProtKB=Q9SAK4	Succinate-semialdehyde dehydrogenase, mitochondrial	ISS	12891648	PubMed	PTHR43353:SF5	SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL
P00048	PI3 kinase pathway	P01199	Galpha	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00772	FIP-2	PANTR|Ensembl=ENSPTRG00000017167|UniProtKB=H2QRD4	Tumor necrosis factor, alpha-induced protein 8	ISS			PTHR12757:SF3	TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 8
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P02722	Acetate utilization	P02801	Acetate kinase	RHOBA|EnsemblGenome=RB2582|UniProtKB=Q7UVK1	Acetate kinase	ISS			PTHR21060:SF11	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04658	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	IGI	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00038	JAK/STAT signaling pathway	P01034	Jak	CANLF|Ensembl=ENSCAFG00000018615|UniProtKB=F1PIY7	Tyrosine-protein kinase	ISS	11929133	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00029	Huntington disease	P00812	Caspase 3	HUMAN|HGNC=1504|UniProtKB=P42574	Caspase-3	IDA	11675509	PubMed	PTHR10454:SF198	CASPASE-3
P00010	B cell activation	P00375	Calmodulin	MONDO|Ensembl=ENSMODG00000002696|UniProtKB=F7CY56	Uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF335	CALMODULIN, STRIATED MUSCLE
P00004	Alzheimer disease-presenilin pathway	P00172	BACE-1	MACMU|Ensembl=ENSMMUG00000007785|UniProtKB=F7CQI1	Beta-secretase 1 isoform A preproprotein	ISS	10531052	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IDA	91072385	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00557	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04668	p53	PANTR|Ensembl=ENSPTRG00000008703|UniProtKB=H2QC53	Cellular tumor antigen p53	ISS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00036	Interleukin signaling pathway	P00980	IRS1/2	BOVIN|Ensembl=ENSBTAG00000021308|UniProtKB=F1MYE0	Uncharacterized protein	ISS	15110093	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P05914	Nicotine degradation	P05984	CYP2A6	MACMU|Ensembl=ENSMMUG00000006394|UniProtKB=F7GWT6	Uncharacterized protein	ISS			PTHR24300:SF180	CYTOCHROME P450 2A13
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P02788	Xanthine and guanine salvage pathway	P03250	Guanosine phosphorylase	BOVIN|Ensembl=ENSBTAG00000012317|UniProtKB=P55859	Purine nucleoside phosphorylase	ISS	9585525	PubMed	PTHR11904:SF12	PURINE NUCLEOSIDE PHOSPHORYLASE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	CANLF|Ensembl=ENSCAFG00000018170|UniProtKB=E2RPM8	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	BOVIN|Ensembl=ENSBTAG00000019210|UniProtKB=F1MJV4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00012	Cadherin signaling pathway	P00470	F-actin	CAEEL|WormBase=WBGene00000063|UniProtKB=P0DM41	Actin-1	IC	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00006	Apoptosis signaling pathway	P00317	Fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00053	T cell activation	P01336	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02772	Pyruvate metabolism	P03141	Citrate Synthetase	ECOLI|EcoGene=EG10402|UniProtKB=P0ABH7	Citrate synthase	ISS	11258796	PubMed	PTHR42871:SF1	CITRATE SYNTHASE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00060	Ubiquitin proteasome pathway	P01494	19S proteasome	MOUSE|MGI=MGI=1346093|UniProtKB=P54775	26S protease regulatory subunit 6B	ISS			PTHR23073:SF8	26S PROTEASE REGULATORY SUBUNIT 6B
P00056	VEGF signaling pathway	P01425	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00005	Angiogenesis	P00205	GAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	14707121	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	BOVIN|Gene=TUBB6|UniProtKB=Q2HJ81	Tubulin beta-6 chain	ISS	12932731	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00019	Endothelin signaling pathway	P00583	cPLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00053	T cell activation	P01312	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00049	Parkinson disease	P01217	beta-Synuclein	MACMU|Ensembl=ENSMMUG00000000137|UniProtKB=F7H5W4	Beta-synuclein	ISS	11683992	PubMed	PTHR13820:SF4	BETA-SYNUCLEIN
P00019	Endothelin signaling pathway	P00566	ERK	ARATH|TAIR=AT1G07880|UniProtKB=Q9LQQ9	Mitogen-activated protein kinase 13	ISS			PTHR24055:SF185	MITOGEN-ACTIVATED PROTEIN KINASE 13
P06664	Gonadotropin-releasing hormone receptor pathway	P06845	Alk4	MOUSE|MGI=MGI=1338944|UniProtKB=Q61271	Activin receptor type-1B	RCA	10683140	PubMed	PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	RCA			PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	TAKRU|Ensembl=ENSTRUG00000016522|UniProtKB=H2UZ46	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	ORNAN|Ensembl=ENSOANG00000000493|UniProtKB=F7EPA8	Uncharacterized protein	ISS	12181435	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-963560|UniProtKB=Q0VFC4	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00052	TGF-beta signaling pathway	P01286	TGFbeta	BOVIN|Ensembl=ENSBTAG00000011743|UniProtKB=F1MF35	Metalloendopeptidase	ISS			PTHR43978:SF1	TOLLOID-LIKE PROTEIN 2
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	RAT|RGD=1310096|UniProtKB=B2RZ72	Actin-related protein 2/3 complex subunit 4	ISS	5031595	gi	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00018	EGF receptor signaling pathway	P00543	ERK1-2	ARATH|TAIR=AT1G53510|UniProtKB=Q9C5C0	Mitogen-activated protein kinase 18	ISS			PTHR24055:SF200	MITOGEN-ACTIVATED PROTEIN KINASE 18-RELATED
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000011757|UniProtKB=Q9XT97	Presenilin-1	IDA	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P00048	PI3 kinase pathway	P01188	Gbetagamma	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	TAS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	ORNAN|Ensembl=ENSOANG00000004783|UniProtKB=F7FN72	Actin-related protein 2/3 complex subunit 3	ISS	12473693	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00046	Oxidative stress response	P01129	JNK1/2	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00010	B cell activation	P00368	vav	PANTR|Ensembl=ENSPTRG00000001024|UniProtKB=H2PZI8	Uncharacterized protein	ISS	14623913	PubMed	PTHR22826:SF97	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3
P00012	Cadherin signaling pathway	P00470	F-actin	TRIVA|Gene=TVAG_090470|UniProtKB=A2FA04	Actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MONDO|Ensembl=ENSMODG00000002435|UniProtKB=F7DZV7	Metalloendopeptidase	ISS	9759503	PubMed	PTHR43978:SF4	TOLLOID-LIKE PROTEIN 1
P00010	B cell activation	P00394	BLNK	MOUSE|MGI=MGI=96878|UniProtKB=Q9QUN3	B-cell linker protein	IGI	11274146	PubMed	PTHR14098:SF3	B-CELL LINKER PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00053	T cell activation	P01314	nck	MOUSE|MGI=MGI=109601|UniProtKB=Q99M51	Cytoplasmic protein NCK1	ISS	12874226	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P00047	PDGF signaling pathway	P01152	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	88318957	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04558	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IDA	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00005	Angiogenesis	P00251	cPLA2	MACMU|Ensembl=ENSMMUG00000021423|UniProtKB=F7EEZ1	Phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P01486	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MOUSE|MGI=MGI=95819|UniProtKB=P35438	Glutamate receptor ionotropic, NMDA 1	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P05917	Opioid proopiomelanocortin pathway	P06011	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	11251832	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_127489|UniProtKB=C3XYC6	Putative uncharacterized protein	IDA	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00005	Angiogenesis	P00219	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	RAT|RGD=62029|UniProtKB=P02563	Myosin-6	ISS	10938134	PubMed	PTHR13140:SF721	MYOSIN-6
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IGI	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MONDO|Ensembl=ENSMODG00000015246|UniProtKB=F6UJF5	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P04376	5HT4 type receptor mediated signaling pathway	P04427	5HT4 Receptor	PANTR|Ensembl=ENSPTRG00000017389|UniProtKB=H2R334	Uncharacterized protein	ISS	12898568	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P00021	FGF signaling pathway	P00628	JNK1-3	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	SCHMA|EnsemblGenome=Smp_030730|UniProtKB=G4LW34	Tubulin beta chain,putative	ISS	12932731	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00951	Jnk	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00558	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MOUSE|MGI=MGI=1336171|UniProtKB=Q9DAS9	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=98953|UniProtKB=P04426	Proto-oncogene Wnt-1	TAS	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00047	PDGF signaling pathway	P01174	Rho	MOUSE|MGI=MGI=2159577|UniProtKB=B1AUY3	Protein Arhgap4	ISS			PTHR14166:SF16	RHO GTPASE-ACTIVATING PROTEIN 4
P00045	Notch signaling pathway	P01104	Serrate	PANTR|Ensembl=ENSPTRG00000013250|UniProtKB=H2QJZ0	Delta-like protein	ISS	10551863	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P06587	Nicotine pharmacodynamics pathway	P06604	SLC18A2	MOUSE|MGI=MGI=106677|UniProtKB=Q8BRU6	Synaptic vesicular amine transporter	TAS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P05913	Enkephalin release	P05977	G-Protein (s)	RAT|RGD=621516|UniProtKB=G3V6P8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00029	Huntington disease	P00805	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01188	Gbetagamma	MACMU|Ensembl=ENSMMUG00000017374|UniProtKB=F7H6T7	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P05730	Endogenous cannabinoid signaling	P05751	Galpha	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2048|UniProtKB=P25099	Adenosine receptor A1	ISS	11781138	PubMed	PTHR24246:SF1	ADENOSINE RECEPTOR A1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P06959	CCKR signaling map	P07069	CLU	HUMAN|HGNC=2095|UniProtKB=P10909	Clusterin	RCA	21995960	PubMed	PTHR10970:SF1	CLUSTERIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00049	Parkinson disease	P01238	14-3-3	PANTR|Ensembl=ENSPTRG00000013529|UniProtKB=H2R8X6	Uncharacterized protein	ISS	1671102	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	MOUSE|MGI=MGI=1321159|UniProtKB=P63330	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01229	Pael-R	MOUSE|MGI=MGI=1313297|UniProtKB=Q9QY42	Prosaposin receptor GPR37	IDA	12150907	PubMed	PTHR24243:SF32	PROSAPOSIN RECEPTOR GPR37
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000000289|UniProtKB=F7A9T0	Uncharacterized protein	ISS	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00053	T cell activation	P01311	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	TAS	2837282	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00034	Integrin signalling pathway	P00923	Arf1	XENTR|Xenbase=XB-GENE-968852|UniProtKB=Q6P7Z6	Uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF294	ADP-RIBOSYLATION FACTOR 3
P00012	Cadherin signaling pathway	P00462	Casein kinase II	CIOIN|Ensembl=ENSCING00000009515|UniProtKB=Q8T3S5	Casein kinase 2 alpha subunit	ISS	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00053	T cell activation	P01307	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00006	Apoptosis signaling pathway	P00314	MKK3	MOUSE|MGI=MGI=1346868|UniProtKB=O09110	Dual specificity mitogen-activated protein kinase kinase 3	IDA	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00018	EGF receptor signaling pathway	P00543	ERK1-2	ARATH|TAIR=AT3G14720|UniProtKB=Q9LUC3	Mitogen-activated protein kinase 19	ISS			PTHR24055:SF200	MITOGEN-ACTIVATED PROTEIN KINASE 18-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	ORYSJ|EnsemblGenome=OS02G0834000|UniProtKB=Q6EP31	Rac-like GTP-binding protein 5	ISS	20318363	PubMed	PTHR24072:SF194	RAC-LIKE GTP-BINDING PROTEIN ARAC4-RELATED
P00010	B cell activation	P00384	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	15737619	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	CAEEL|WormBase=WBGene00000254|UniProtKB=P51559	Endoprotease bli-4	IDA			PTHR42884:SF18	ENDOPROTEASE BLI-4
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02772	Pyruvate metabolism	P03135	Phosphoenolpyruvate Carboxykinase	RAT|RGD=3267|UniProtKB=P07379	Phosphoenolpyruvate carboxykinase, cytosolic [GTP]	ISS	8325643	PubMed	PTHR11561:SF1	PHOSPHOENOLPYRUVATE CARBOXYKINASE, CYTOSOLIC  GTP
P04397	p53 pathway by glucose deprivation	P04636	S6K	MONDO|Ensembl=ENSMODG00000014313|UniProtKB=F7BTW0	Ribosomal protein S6 kinase	ISS	11861821	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00006	Apoptosis signaling pathway	P00310	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P05915	Opioid proenkephalin pathway	P05994	G-protein	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	TRYB2|Gene=Tb11.02.5720|UniProtKB=Q384N4	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00018	EGF receptor signaling pathway	P00552	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	HUMAN|HGNC=4571|UniProtKB=P42261	Glutamate receptor 1	ISS	12941441	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-7595|UniProtKB=Q6PBR4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04398	p53 pathway feedback loops 2	P04665	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00023	General transcription regulation	P00670	TBP	CANLF|Ensembl=ENSCAFG00000014931|UniProtKB=E2RCC0	Uncharacterized protein	ISS			PTHR15938:SF0	HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	DANRE|ZFIN=ZDB-GENE-050706-89|UniProtKB=F1RDG9	Tyrosine-protein kinase fynb	ISS	11162638	PubMed	PTHR24418:SF242	TYROSINE-PROTEIN KINASE FYNB
P00010	B cell activation	P00391	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00054	Toll receptor signaling pathway	P01360	IKKbeta	BOVIN|Ensembl=ENSBTAG00000007599|UniProtKB=Q95KV0	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEEL|WormBase=WBGene00018620|UniProtKB=O44588	Uncharacterized protein	ISS	11880265	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	BOVIN|Ensembl=ENSBTAG00000002107|UniProtKB=A7MB15	FZD1 protein	ISS	8717036	PubMed	PTHR11309:SF81	FRIZZLED-1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00011	Blood coagulation	P00415	Plasmin	PANTR|Ensembl=ENSPTRG00000018774|UniProtKB=H2QU06	Plasminogen	ISS	4505881	gi	PTHR24261:SF6	PLASMINOGEN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DICDI|dictyBase=DDB_G0286555|UniProtKB=P34147	Rho-related protein racA	ISS	94124042	PubMed	PTHR24072:SF183	RHO-RELATED PROTEIN RACA
P00054	Toll receptor signaling pathway	P01338	IkappaB	HUMAN|HGNC=7797|UniProtKB=P25963	NF-kappa-B inhibitor alpha	ISS	14665694	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00892	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	11384839	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02749	Leucine biosynthesis	P03000	Branched chain amino acid aminotransferase	HUMAN|HGNC=977|UniProtKB=O15382	Branched-chain-amino-acid aminotransferase, mitochondrial	ISS			PTHR11825:SF39	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, MITOCHONDRIAL
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00050	Plasminogen activating cascade	P01252	MMP-1	PANTR|Ensembl=ENSPTRG00000023318|UniProtKB=H2Q4N3	Matrix metallopeptidase 1 (Interstitial collagenase)	ISS	12834808	PubMed	PTHR10201:SF151	INTERSTITIAL COLLAGENASE
P00029	Huntington disease	P00805	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEEL|WormBase=WBGene00018620|UniProtKB=O44588	Uncharacterized protein	ISS	15572354	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P00018	EGF receptor signaling pathway	P00547	PP2A	XENTR|Xenbase=XB-GENE-484003|UniProtKB=Q6P365	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04417	5HT transporter	RAT|RGD=3714|UniProtKB=P31652	Sodium-dependent serotonin transporter	ISS	7681602	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P00018	EGF receptor signaling pathway	P00543	ERK1-2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01447	Dishevelled	CHICK|Ensembl=ENSGALG00000008414|UniProtKB=F1P5N3	Uncharacterized protein	ISS	11212302	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P00018	EGF receptor signaling pathway	P00559	MEK1-2	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00010	B cell activation	P00367	NFAT	RAT|RGD=1307690|UniProtKB=D4A0I8	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (Predicted), isoform CRA_b	ISS	9462517	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	ANOGA|EnsemblGenome=AGAP004622|UniProtKB=Q7PPE1	Glutamate dehydrogenase	ISS			PTHR11606:SF7	GLUTAMATE DEHYDROGENASE
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00551	Akt	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	IGI	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00786	ARF	ANOGA|EnsemblGenome=AGAP002931|UniProtKB=Q7PQY7	AGAP002931-PA	ISS	12932731	PubMed	PTHR11711:SF308	ADP-RIBOSYLATION FACTOR 5
P00005	Angiogenesis	P00256	PLC-gamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00108	ADAM10	CHICK|Ensembl=ENSGALG00000004212|UniProtKB=F6VMG5	Uncharacterized protein	IDA	10097139	PubMed	PTHR11905:SF4	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 10
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	ORNAN|Ensembl=ENSOANG00000004058|UniProtKB=F6TYP9	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P04393	Ras Pathway	P04546	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	BACSU|EnsemblGenome=BSU22730|UniProtKB=P31103	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	RAT|RGD=69319|UniProtKB=P54313	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P06664	Gonadotropin-releasing hormone receptor pathway	P06807	gnai	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	RCA	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02742	Tetrahydrofolate biosynthesis	P02945	Dihydropteroate synthase	ARATH|TAIR=AT4G30000|UniProtKB=Q9SZV3	Folate synthesis bifunctional protein, mitochondrial	ISS			PTHR20941:SF1	FOLIC ACID SYNTHESIS PROTEIN FOL1
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	BOVIN|Ensembl=ENSBTAG00000009835|UniProtKB=F1MR37	Uncharacterized protein	ISS	18021322	PubMed	PTHR10037:SF137	VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1G
P06959	CCKR signaling map	P07068	PKCeta	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	RCA	17962809	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00034	Integrin signalling pathway	P00951	Jnk	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04393	Ras Pathway	P04542	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	PANTR|Ensembl=ENSPTRG00000008665|UniProtKB=H2QC24	Dishevelled, dsh homolog 2	ISS	11212302	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P02724	Alanine biosynthesis	P02815	Branched chain amino acid aminotransferase	AQUAE|EnsemblGenome=aq_1893|UniProtKB=O67733	Probable branched-chain-amino-acid aminotransferase	ISS			PTHR42743:SF4	SUBFAMILY NOT NAMED
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=101848|UniProtKB=P62881	Guanine nucleotide-binding protein subunit beta-5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P05913	Enkephalin release	P05972	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00948	Rho	RAT|RGD=1304965|UniProtKB=A0A0G2K6E0	Protein Rhoc	ISS	14871999	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00056	VEGF signaling pathway	P01411	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	CANLF|Ensembl=ENSCAFG00000008653|UniProtKB=F1PE26	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	HUMAN|HGNC=130|UniProtKB=P62736	Actin, aortic smooth muscle	IEP	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P04393	Ras Pathway	P04546	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00011	Blood coagulation	P00406	Fibrinogen	XENTR|Xenbase=XB-GENE-483216|UniProtKB=B0JZ09	Fgb protein	ISS	1160337	gi	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00021	FGF signaling pathway	P00638	PLCgamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g210933|UniProtKB=A7SEA7	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	P01456	beta-arrestin	CANLF|Ensembl=ENSCAFG00000015905|UniProtKB=E2QUH6	Uncharacterized protein	ISS	4757780	gi	PTHR11792:SF20	BETA-ARRESTIN-2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02916	dTMP kinase	PYRAE|EnsemblGenome=PAE0964|UniProtKB=Q8ZY35	Probable thymidylate kinase	ISS			PTHR10344:SF1	THYMIDYLATE KINASE
P00047	PDGF signaling pathway	P01161	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00920	SOS	CHICK|Ensembl=ENSGALG00000013224|UniProtKB=F1NMA4	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00010	B cell activation	P00373	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00036	Interleukin signaling pathway	P00967	c-fos	RAT|RGD=2626|UniProtKB=P12841	Proto-oncogene c-Fos	TAS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P02738	De novo purine biosynthesis	P02901	Adenosuccinate lyase	MYCTU|EnsemblGenome=LH57_04215|UniProtKB=I6XWA1	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	XENTR|Xenbase=XB-GENE-5752629|UniProtKB=F6UBB9	Uncharacterized protein	ISS	1589771	PubMed	PTHR10024:SF239	SYNAPTOTAGMIN-1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	PANTR|Ensembl=ENSPTRG00000008770|UniProtKB=H2QC99	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF385	MYOSIN-2
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	RCA			PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MOUSE|MGI=MGI=105372|UniProtKB=P49660	Somatostatin receptor type 4	IDA			PTHR24229:SF52	SOMATOSTATIN RECEPTOR TYPE 4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IDA	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	PANTR|Gene=HTR1E|UniProtKB=Q9N2B6	5-hydroxytryptamine receptor 1E (Fragment)	ISS	12441358	PubMed	PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P00010	B cell activation	P00376	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00018	EGF receptor signaling pathway	P00547	PP2A	IXOSC|EnsemblGenome=ISCW014549|UniProtKB=B7QGY5	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06836	PG Rcs	MOUSE|MGI=MGI=99535|UniProtKB=P43252	Prostacyclin receptor	RCA			PTHR11866:SF7	PROSTACYCLIN RECEPTOR
P06959	CCKR signaling map	P07231	Pro-caspase-3	HUMAN|HGNC=1504|UniProtKB=P42574	Caspase-3	RCA	18565785	PubMed	PTHR10454:SF198	CASPASE-3
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000012539|UniProtKB=H2RC03	Uncharacterized protein	ISS			PTHR11824:SF7	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4
P00029	Huntington disease	P00780	Microtubule	BOVIN|Ensembl=ENSBTAG00000023730|UniProtKB=Q2T9S0	Tubulin beta-3 chain	ISS	12932731	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00048	PI3 kinase pathway	P01199	Galpha	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P06664	Gonadotropin-releasing hormone receptor pathway	P06849	Sos	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	RCA	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00059	p53 pathway	P01482	ARF	MACMU|Ensembl=ENSMMUG00000011953|UniProtKB=F7HID8	Cyclin-dependent kinase 4 inhibitor D	ISS			PTHR24148:SF47	CYCLIN-DEPENDENT KINASE 4 INHIBITOR B-RELATED
P00049	Parkinson disease	P01208	Hsp70	DROME|FlyBase=FBgn0013275|UniProtKB=P82910	Major heat shock 70 kDa protein Aa	IDA	12150907	PubMed	PTHR19375:SF256	HSP70 PROTEIN-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	TAS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04392	P53 pathway feedback loops 1	P04536	Mdm2	RAT|RGD=1309306|UniProtKB=Q5XIN1	Protein Mdm4	ISS			PTHR13844:SF20	PROTEIN MDM4
P02788	Xanthine and guanine salvage pathway	P03250	Guanosine phosphorylase	BACSU|EnsemblGenome=BSU23490|UniProtKB=P46354	Purine nucleoside phosphorylase 1	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00705	Gsalpha	MONDO|Ensembl=ENSMODG00000021434|UniProtKB=F7CB49	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01021	Vglut	MOUSE|MGI=MGI=103209|UniProtKB=Q61983	Sodium-dependent phosphate transport protein 1	ISS			PTHR11662:SF26	SODIUM-DEPENDENT PHOSPHATE TRANSPORT PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT2G18170|UniProtKB=Q39027	Mitogen-activated protein kinase 7	ISS	10514528	PubMed	PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00047	PDGF signaling pathway	P01160	IP3 receptor	CAEEL|WormBase=WBGene00002173|UniProtKB=Q9Y0A1	Inositol 1,4,5-trisphosphate receptor itr-1	ISS	9065779	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P02778	Sulfate assimilation	P03167	Sulfate adenylyltransferase	MACMU|Ensembl=ENSMMUG00000019907|UniProtKB=F7GNZ7	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1	ISS			PTHR11055:SF17	BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE 1
P05913	Enkephalin release	P05972	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00057	Wnt signaling pathway	P01448	CBP	MOUSE|MGI=MGI=1276116|UniProtKB=B2RWS6	Histone acetyltransferase p300	ISS	8413673	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04398	p53 pathway feedback loops 2	P04661	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01407	Erk	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00052	TGF-beta signaling pathway	P01286	TGFbeta	DANRE|ZFIN=ZDB-GENE-000208-25|UniProtKB=Q9PTF9	Bone morphogenetic protein 7	TAS	9759503	PubMed	PTHR11848:SF172	BONE MORPHOGENETIC PROTEIN 7
P00010	B cell activation	P00375	Calmodulin	STRPU|EnsemblGenome=SPU_005033|UniProtKB=W4XNQ0	Uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF263	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	ARATH|TAIR=AT3G14720|UniProtKB=Q9LUC3	Mitogen-activated protein kinase 19	TAS			PTHR24055:SF200	MITOGEN-ACTIVATED PROTEIN KINASE 18-RELATED
P00019	Endothelin signaling pathway	P00583	cPLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00561	STAT	PANTR|Ensembl=ENSPTRG00000009200|UniProtKB=H2QD20	Signal transducer and activator of transcription	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MONDO|Ensembl=ENSMODG00000000771|UniProtKB=F6SSS3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=2442792|UniProtKB=Q8BM92	Cadherin-7	ISS	8120095	PubMed	PTHR24027:SF91	CADHERIN-7
P00003	Alzheimer disease-amyloid secretase pathway	P00081	Pro-BACE-1	HUMAN|HGNC=933|UniProtKB=P56817	Beta-secretase 1	IDA	10956649	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P05730	Endogenous cannabinoid signaling	P05748	mGluR	HUMAN|HGNC=4597|UniProtKB=P41594	Metabotropic glutamate receptor 5	ISS	14614461	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P02754	Methylcitrate cycle	P03028	Aconitase	MONDO|Ensembl=ENSMODG00000004463|UniProtKB=F7CLP5	Aconitate hydratase	ISS			PTHR11670:SF32	CYTOPLASMIC ACONITATE HYDRATASE
P02738	De novo purine biosynthesis	P02891	GDP kinase	EMENI|EnsemblGenome=CADANIAG00004263|UniProtKB=Q8TFN0	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P04395	Vasopressin synthesis	P04596	Endo Peptidase	DICDI|dictyBase=DDB_G0274387|UniProtKB=Q86AS5	Prolyl endopeptidase	IC	9695945	PubMed	PTHR42881:SF2	PROLYL ENDOPEPTIDASE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF330	SUBFAMILY NOT NAMED
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	XENTR|Xenbase=XB-GENE-1010483|UniProtKB=F7AF72	Uncharacterized protein	ISS	20112749	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P02776	Serine glycine biosynthesis	P03159	Phosphoserine phosphatase	CANLF|Ensembl=ENSCAFG00000010123|UniProtKB=E2RPN5	Uncharacterized protein	ISS			PTHR43344:SF2	PHOSPHOSERINE PHOSPHATASE
P04398	p53 pathway feedback loops 2	P04658	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BOVIN|Gene=ACTG2|UniProtKB=Q5E9B5	Actin, gamma-enteric smooth muscle	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CANLF|Ensembl=ENSCAFG00000002617|UniProtKB=E2QUL1	Uncharacterized protein	ISS	11554554	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00012	Cadherin signaling pathway	P00477	GSK3beta	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00021	FGF signaling pathway	P00629	PP2A	SCHPO|PomBase=SPBC26H8.05c|UniProtKB=O74789	Putative serine/threonine-protein phosphatase C26H8.05c	ISS			PTHR11668:SF22	SERINE/THREONINE-PROTEIN PHOSPHATASE 4 CATALYTIC SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00877	MLCK	CHICK|Ensembl=ENSGALG00000006273|UniProtKB=E1BX17	Uncharacterized protein	IDA	11157482	PubMed	PTHR45210:SF1	MYOSIN LIGHT CHAIN KINASE 2, SKELETAL/CARDIAC MUSCLE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00642	MEK1-2	LEIMA|EnsemblGenome=LmjF.13.0440|UniProtKB=Q4QGB0	Mitogen-activated protein kinase kinase 2	ISS			PTHR22983:SF6	SERINE/THREONINE-PROTEIN KINASE 36
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	TAS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	DANRE|ZFIN=ZDB-GENE-000322-1|UniProtKB=Q9I8V1	Actin, alpha 1, skeletal muscle	IC	11889126	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00047	PDGF signaling pathway	P01161	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	15737619	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01208	Hsp70	YARLI|EnsemblGenome=YALI0_E13706g|UniProtKB=Q99170	78 kDa glucose-regulated protein homolog	IDA	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00053	T cell activation	P01312	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	HUMAN|HGNC=4584|UniProtKB=Q05586	Glutamate receptor ionotropic, NMDA 1	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04393	Ras Pathway	P04567	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00964	p90RSK	BOVIN|Ensembl=ENSBTAG00000014447|UniProtKB=A4IFF4	Ribosomal protein S6 kinase	ISS	12213813	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	BOVIN|Ensembl=ENSBTAG00000007635|UniProtKB=F1MLS3	Phosphoinositide phospholipase C	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00045	Notch signaling pathway	P01118	Numb	RAT|RGD=620107|UniProtKB=Q2LC84	Protein numb homolog	ISS	8755477	PubMed	PTHR11232:SF33	PROTEIN NUMB HOMOLOG
P00010	B cell activation	P00392	I kappa B	CHICK|Gene=NFKBIA|UniProtKB=Q91974	NF-kappa-B inhibitor alpha	IDA	14665694	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P04393	Ras Pathway	P04570	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04413	K+ channel	MOUSE|MGI=MGI=1100509|UniProtKB=O35111	Potassium channel subfamily K member 3	ISS	15282272	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00029	Huntington disease	P00775	Rac	ORYSJ|EnsemblGenome=OS02G0834000|UniProtKB=Q6EP31	Rac-like GTP-binding protein 5	ISS			PTHR24072:SF194	RAC-LIKE GTP-BINDING PROTEIN ARAC4-RELATED
P00022	General transcription by RNA polymerase I	P00652	RNA Polymerase I  Complex	CAEEL|WormBase=WBGene00008781|UniProtKB=Q27493	DNA-directed RNA polymerase subunit beta	ISS	15691654	PubMed	PTHR20856:SF5	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA2
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MOUSE|MGI=MGI=98725|UniProtKB=P04202	Transforming growth factor beta-1	TAS	9759503	PubMed	PTHR11848:SF125	TRANSFORMING GROWTH FACTOR BETA-1
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	BOVIN|Ensembl=ENSBTAG00000018777|UniProtKB=E1BHU9	Uncharacterized protein	ISS	1409703	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	9166716	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	XENTR|Xenbase=XB-GENE-976753|UniProtKB=Q0VFR6	Syntaxin 1A (Brain)	ISS	1321498	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00012	Cadherin signaling pathway	P00475	Frizzled	CAEBR|Gene=CBG03824|UniProtKB=A8WWU4	Protein CBR-MOM-5	ISS	8717036	PubMed	PTHR11309:SF47	FRIZZLED
P04393	Ras Pathway	P04553	PAK	RAT|RGD=3250|UniProtKB=P35465	Serine/threonine-protein kinase PAK 1	IDA	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	BOVIN|Ensembl=ENSBTAG00000010386|UniProtKB=Q3MHR7	Actin-related protein 2/3 complex subunit 2	TAS	10940259	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	RCA	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	IC	15572354	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05915	Opioid proenkephalin pathway	P05994	G-protein	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04378	Beta2 adrenergic receptor signaling pathway	P04440	Beta2	PANTR|Ensembl=ENSPTRG00000017391|UniProtKB=D3K5P1	Adrenergic, beta-2-, receptor, surface	ISS	7669252	PubMed	PTHR24248:SF21	BETA-2 ADRENERGIC RECEPTOR
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05916	Opioid prodynorphin pathway	P06000	vasopressin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00048	PI3 kinase pathway	P01179	PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00371	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00012	Cadherin signaling pathway	P00470	F-actin	MOUSE|MGI=MGI=104589|UniProtKB=P63268	Actin, gamma-enteric smooth muscle	IC	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF248	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	89186920	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	MACMU|Ensembl=ENSMMUG00000021785|UniProtKB=F7DED8	Serine hydroxymethyltransferase	ISS			PTHR11680:SF17	SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL
P00029	Huntington disease	P00785	Cytochrome c	ORYSJ|EnsemblGenome=OS05G0301700|UniProtKB=Q0DJC3	Os05g0301700 protein	IDA	15163634	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00005	Angiogenesis	P00209	FAK	PANTR|Ensembl=ENSPTRG00000020624|UniProtKB=H2QWS1	Uncharacterized protein	ISS	12640026	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00029	Huntington disease	P00811	Arp2/3 complex	MOUSE|MGI=MGI=1928896|UniProtKB=Q9R0Q6	Actin-related protein 2/3 complex subunit 1A	TAS	12932731	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00019	Endothelin signaling pathway	P00589	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	NAS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	HUMAN|HGNC=6697|UniProtKB=O75197	Low-density lipoprotein receptor-related protein 5	IDA	11029006	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00018	EGF receptor signaling pathway	P00565	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	15572354	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00005	Angiogenesis	P00221	JNK1	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00009	Axon guidance mediated by netrin	P00363	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CHICK|Ensembl=ENSGALG00000008512|UniProtKB=F1P0S6	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00018	EGF receptor signaling pathway	P00543	ERK1-2	SCHPO|PomBase=SPBC119.08|UniProtKB=Q92398	Mitogen-activated protein kinase spm1	ISS			PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	ORYSJ|EnsemblGenome=OS02G0120800|UniProtKB=Q6ZHA3	Rac-like GTP-binding protein 6	ISS	11950993	PubMed	PTHR24072:SF261	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01428	Frizzled	DROME|FlyBase=FBgn0001085|UniProtKB=P18537	Frizzled	IDA	8717036	PubMed	PTHR11309:SF47	FRIZZLED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PHYPA|Gene=PHYPADRAFT_172686|UniProtKB=A9TYG6	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00029	Huntington disease	P00775	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	SCHPO|PomBase=SPAC23C4.15|UniProtKB=Q09191	DNA-directed RNA polymerases I, II, and III subunit RPABC1	ISS	11313498	gi	PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	DANRE|ZFIN=ZDB-GENE-051202-2|UniProtKB=Q6ZM67	Uncharacterized protein	ISS	14698601	PubMed	PTHR44391:SF3	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P02723	Adenine and hypoxanthine salvage pathway	P02809	Xanthine dehydrogenase	PANTR|Ensembl=ENSPTRG00000011806|UniProtKB=H2QHQ2	Uncharacterized protein	ISS	11307944	PubMed	PTHR11908:SF80	XANTHINE DEHYDROGENASE/OXIDASE
P00021	FGF signaling pathway	P00629	PP2A	PANTR|Ensembl=ENSPTRG00000011406|UniProtKB=H2QH17	Protein phosphatase 2, regulatory subunit A, alpha	ISS	11994459	PubMed	PTHR10648:SF2	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 65 KDA REGULATORY SUBUNIT A ALPHA ISOFORM
P00021	FGF signaling pathway	P00640	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	IDA	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P06664	Gonadotropin-releasing hormone receptor pathway	P06798	PKCe/theta	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00036	Interleukin signaling pathway	P00987	SRF	BOVIN|Ensembl=ENSBTAG00000012777|UniProtKB=E1BJP4	Uncharacterized protein	ISS	15170389	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	SCHPO|PomBase=SPAC6G9.07c|UniProtKB=Q92352	Actin-related protein 2/3 complex subunit 4	ISS	5031595	gi	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	PANTR|Ensembl=ENSPTRG00000006342|UniProtKB=H2Q8A8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00005	Angiogenesis	P00203	Erk	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	XENTR|Xenbase=XB-GENE-1031985|UniProtKB=Q6GL68	Transcription factor 7-like 1	ISS	11266476	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00054	Toll receptor signaling pathway	P01364	TPL2	BOVIN|Ensembl=ENSBTAG00000011600|UniProtKB=A5PK86	MAP3K8 protein	ISS	92019818	PubMed	PTHR24361:SF94	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 8
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00053	T cell activation	P01305	Calmodulin	CANLF|Ensembl=ENSCAFG00000030049|UniProtKB=J9NWQ5	Uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF311	CALMODULIN
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00029	Huntington disease	P00786	ARF	CHICK|Ensembl=ENSGALG00000005393|UniProtKB=F1NN08	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF234	ADP-RIBOSYLATION FACTOR 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00627	ERK1-2	CHLRE|EnsemblGenome=CHLREDRAFT_193901|UniProtKB=Q9FXT7	Mitogen-activated protein kinase	NAS			PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	XENTR|Xenbase=XB-GENE-961282|UniProtKB=Q6DF43	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00053	T cell activation	P01315	Calcineurin	BOVIN|Ensembl=ENSBTAG00000020133|UniProtKB=A5D7T5	Serine/threonine-protein phosphatase	ISS	12091710	PubMed	PTHR11668:SF186	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT GAMMA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	CANLF|Ensembl=ENSCAFG00000004882|UniProtKB=F1PAE3	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DROME|FlyBase=FBgn0001122|UniProtKB=P16378	G protein alpha o subunit	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	PANTR|Ensembl=ENSPTRG00000010617|UniProtKB=H2QFL8	Notch 3	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P04396	Vitamin D metabolism and pathway	P04606	VDR	HUMAN|HGNC=12679|UniProtKB=P11473	Vitamin D3 receptor	IDA	11705326	PubMed	PTHR24082:SF38	VITAMIN D3 RECEPTOR
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	PSEAE|EnsemblGenome=PA4602|UniProtKB=Q9HVI7	Serine hydroxymethyltransferase 3	ISS			PTHR11680:SF21	SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC
P05915	Opioid proenkephalin pathway	P05991	Enkephalin	DANRE|ZFIN=ZDB-GENE-030729-31|UniProtKB=A8E7S2	Uncharacterized protein	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	PRIPA|Gene=PPA22610|UniProtKB=H3FK05	Uncharacterized protein	ISS			PTHR24072:SF192	CDC42 HOMOLOG
P00008	Axon guidance mediated by Slit/Robo	P00351	Cxcr4	BOVIN|Ensembl=ENSBTAG00000001060|UniProtKB=P25930	C-X-C chemokine receptor type 4	ISS	11943720	PubMed	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	PRIPA|Gene=PPA25500|UniProtKB=H3FT78	Uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00037	Ionotropic glutamate receptor pathway	P01001	KA4	MACMU|Ensembl=ENSMMUG00000022347|UniProtKB=F6ZCH5	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	HUMAN|HGNC=10941|UniProtKB=P43003	Excitatory amino acid transporter 1	IC	94365697	PubMed	PTHR11958:SF24	EXCITATORY AMINO ACID TRANSPORTER 1
P00048	PI3 kinase pathway	P01188	Gbetagamma	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00047	PDGF signaling pathway	P01150	PKC	RAT|RGD=620146|UniProtKB=O08874	Serine/threonine-protein kinase N2	ISS	11880265	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00010	B cell activation	P00391	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	ISS	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P00021	FGF signaling pathway	P00645	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00269	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04397	p53 pathway by glucose deprivation	P04641	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DROME|FlyBase=FBgn0004623|UniProtKB=P29829	Guanine nucleotide-binding protein subunit beta-2	IC			PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00053	T cell activation	P01311	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00318	PKCs	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	IC	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01161	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01402	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	RCA			PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04398	p53 pathway feedback loops 2	P04651	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	3035212	PubMed	PTHR24070:SF385	GTPASE HRAS
P06664	Gonadotropin-releasing hormone receptor pathway	P06798	PKCe/theta	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00036	Interleukin signaling pathway	P00990	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04398	p53 pathway feedback loops 2	P04665	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MOUSE|MGI=MGI=87904|UniProtKB=P60710	Actin, cytoplasmic 1	IDA	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01176	JAK	BOVIN|Ensembl=ENSBTAG00000012047|UniProtKB=E1BCP6	Tyrosine-protein kinase	ISS	22482294	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05913	Enkephalin release	P05978	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00005	Angiogenesis	P00235	c-Fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00006	Apoptosis signaling pathway	P00260	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00190	RasGAP	HUMAN|HGNC=9871|UniProtKB=P20936	Ras GTPase-activating protein 1	IDA	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05730	Endogenous cannabinoid signaling	P05746	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MONDO|Ensembl=ENSMODG00000012546|UniProtKB=F6PM16	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IDA	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00046	Oxidative stress response	P01137	MNK1/2	MACMU|Ensembl=ENSMMUG00000011265|UniProtKB=F6WP09	Uncharacterized protein	ISS	9155017	PubMed	PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00004	Alzheimer disease-presenilin pathway	P00114	actin	TRIAD|EnsemblGenome=TriadG35956|UniProtKB=Q7YTV5	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	ARATH|TAIR=AT4G11010|UniProtKB=O49203	Nucleoside diphosphate kinase III, chloroplastic/mitochondrial	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8655|UniProtKB=Q08174	Protocadherin-1	IDA	8120095	PubMed	PTHR43912:SF3	PROTOCADHERIN-1
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04398	p53 pathway feedback loops 2	P04650	WIP-1	MOUSE|MGI=MGI=1858214|UniProtKB=Q9QZ67	Protein phosphatase 1D	ISS			PTHR13832:SF359	PROTEIN PHOSPHATASE 1D
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06803	Rap1b	MOUSE|MGI=MGI=894315|UniProtKB=Q99JI6	Ras-related protein Rap-1b	RCA	1904317	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00036	Interleukin signaling pathway	P00965	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00036	Interleukin signaling pathway	P00964	p90RSK	HUMAN|HGNC=10432|UniProtKB=P51812	Ribosomal protein S6 kinase alpha-3	ISS	10480933	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00018	EGF receptor signaling pathway	P00540	MKK3,6	BOVIN|Ensembl=ENSBTAG00000010576|UniProtKB=A4IFH7	MAP2K3 protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00034	Integrin signalling pathway	P00936	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	IC	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	CAEBR|Gene=CBG02247|UniProtKB=A8WS68	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00006	Apoptosis signaling pathway	P00318	PKCs	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00009	Axon guidance mediated by netrin	P00359	NFAT	MACMU|Ensembl=ENSMMUG00000003370|UniProtKB=F7E8G2	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	BOVIN|Ensembl=ENSBTAG00000003512|UniProtKB=E1BPX8	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF358	MYOSIN-7B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04393	Ras Pathway	P04557	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00057	Wnt signaling pathway	P01444	Wnt	BRAFL|Gene=BRAFLDRAFT_56711|UniProtKB=C3XPR5	Protein Wnt	IDA	8717036	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00053	T cell activation	P01312	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IDA	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P02738	De novo purine biosynthesis	P02909	GDP reductase	DROME|FlyBase=FBgn0011704|UniProtKB=P48592	Ribonucleoside-diphosphate reductase subunit M2	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00006	Apoptosis signaling pathway	P00275	Bak	MOUSE|MGI=MGI=1097161|UniProtKB=O08734	Bcl-2 homologous antagonist/killer	ISS	7715730	PubMed	PTHR11256:SF41	BCL-2 HOMOLOGOUS ANTAGONIST/KILLER
P04393	Ras Pathway	P04557	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	IDA	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01026	KA	RAT|RGD=2733|UniProtKB=P42260	Glutamate receptor ionotropic, kainate 2	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00053	T cell activation	P01318	PKC-theta	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	CAEBR|Gene=CBG05056|UniProtKB=A8WZ27	Protein CBR-GLT-4	ISS	94365697	PubMed	PTHR11958:SF56	SODIUM-DEPENDENT EXCITATORY AMINO ACID TRANSPORTER GLT-4-RELATED
P00025	Hedgehog signaling pathway	P00691	CBP	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00993	p21CIP1	HUMAN|HGNC=1784|UniProtKB=P38936	Cyclin-dependent kinase inhibitor 1	IC			PTHR10265:SF16	CYCLIN-DEPENDENT KINASE INHIBITOR 1
P00012	Cadherin signaling pathway	P00462	Casein kinase II	XENTR|Xenbase=XB-GENE-487069|UniProtKB=F6RN85	Uncharacterized protein	ISS	10806215	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00024	Glycolysis	P00680	Phosphoglyceromutase	RAT|RGD=3313|UniProtKB=P16290	Phosphoglycerate mutase 2	RCA			PTHR11931:SF8	PHOSPHOGLYCERATE MUTASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	TAS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04393	Ras Pathway	P04567	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	BOVIN|Ensembl=ENSBTAG00000026580|UniProtKB=F1MB93	Uncharacterized protein	ISS	1608964	PubMed	PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P04393	Ras Pathway	P04543	MEKK1/4	MOUSE|MGI=MGI=1346875|UniProtKB=O08648	Mitogen-activated protein kinase kinase kinase 4	IDA	602425	OMIM	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00011	Blood coagulation	P00433	uPAR	BOVIN|Ensembl=ENSBTAG00000005947|UniProtKB=Q05589	Urokinase-type plasminogen activator	IC			PTHR24264:SF38	UROKINASE-TYPE PLASMINOGEN ACTIVATOR
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00048	PI3 kinase pathway	P01177	P110ACT	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02751	Lysine biosynthesis	P03012	N-succinyl-diaminopimelate desuccinylase	SULSO|EnsemblGenome=SSO1007|UniProtKB=Q97ZB7	Acetylornithine deacetylase (ArgE-2)	ISS			PTHR43808:SF3	ACETYLORNITHINE DEACETYLASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00006	Apoptosis signaling pathway	P00321	HSP70	ARATH|TAIR=AT5G02500|UniProtKB=P22953	Probable mediator of RNA polymerase II transcription subunit 37e	ISS	12150907	PubMed	PTHR19375:SF325	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 37E-RELATED
P00010	B cell activation	P00381	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	IGI	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00005	Angiogenesis	P00223	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00591	PLCbeta	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000016666|UniProtKB=H2QQJ6	Uncharacterized protein	ISS	8120095	PubMed	PTHR24026:SF42	PROTOCADHERIN FAT 1
P00019	Endothelin signaling pathway	P00590	IP3 R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IGI	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	XENTR|Xenbase=XB-GENE-494200|UniProtKB=F7CS79	Uncharacterized protein	ISS	11554554	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P05918	p38 MAPK pathway	P06029	p38beta	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	RCA	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00059	p53 pathway	P04609	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4394|UniProtKB=P19087	Guanine nucleotide-binding protein G(t) subunit alpha-2	ISS	12488551	PubMed	PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P00010	B cell activation	P00375	Calmodulin	RAT|RGD=2257|UniProtKB=P62161	Calmodulin	ISS	9753452	PubMed	PTHR23050:SF311	CALMODULIN
P00059	p53 pathway	G04694	p110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05913	Enkephalin release	P05977	G-Protein (s)	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00034	Integrin signalling pathway	P00922	Collagen	RAT|RGD=1565398|UniProtKB=D3ZUL3	Protein Col6a1	ISS	10727440	PubMed	PTHR44172:SF3	COLLAGEN ALPHA-1 VI  CHAIN
P00021	FGF signaling pathway	P00645	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P02783	Tryptophan biosynthesis	P03209	Anthranilate phosphoribosyl transferase	BACTN|EnsemblGenome=BT_0531|UniProtKB=Q8AAD4	Anthranilate synthase component II	ISS			PTHR43418:SF4	MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	PANTR|Ensembl=ENSPTRG00000011049|UniProtKB=H2QGF9	Glycogen synthase kinase 3 alpha	ISS	11995474	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00012	Cadherin signaling pathway	P00474	Wnt	MACMU|Ensembl=ENSMMUG00000000180|UniProtKB=F7HJM7	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	RCA	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02729	Ascorbate degradation	P02851	L-ribulose-5-phosphate-4-epimerase	BACSU|EnsemblGenome=BSU28780|UniProtKB=P94525	L-ribulose-5-phosphate 4-epimerase	ISS			PTHR22789:SF8	L-RIBULOSE-5-PHOSPHATE 4-EPIMERASE SGBE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	DROME|FlyBase=FBgn0022710|UniProtKB=M9PEP2	Adenylyl cyclase 35C, isoform C	IDA	2491850	PubMed	PTHR11920:SF319	ADENYLATE CYCLASE TYPE 9
P00029	Huntington disease	P00807	Actin	HUMAN|HGNC=129|UniProtKB=P68133	Actin, alpha skeletal muscle	IDA	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00570	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000014828|UniProtKB=F1N1E0	Uncharacterized protein	ISS	11976940	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	PANTR|Ensembl=ENSPTRG00000009200|UniProtKB=H2QD20	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	YEAST|SGD=S000004219|UniProtKB=P19073	Cell division control protein 42	ISS	11156982	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MACMU|Ensembl=ENSMMUG00000023584|UniProtKB=F7HFU0	Uncharacterized protein	ISS			PTHR10489:SF730	CHEMOKINE XC RECEPTOR 1
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04552	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02751	Lysine biosynthesis	P03006	Dihydrodipicolinate  reductase	ARATH|TAIR=AT5G52100|UniProtKB=Q9FJ82	Dihydrodipicolinate reductase-like protein CRR1, chloroplastic	ISS			PTHR20836:SF0	DIHYDRODIPICOLINATE REDUCTASE-LIKE PROTEIN CRR1, CHLOROPLASTIC
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	PANTR|Ensembl=ENSPTRG00000009200|UniProtKB=H2QD20	Signal transducer and activator of transcription	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	HUMAN|HGNC=11334|UniProtKB=P35346	Somatostatin receptor type 5	IDA			PTHR24229:SF20	SOMATOSTATIN RECEPTOR TYPE 5
P00009	Axon guidance mediated by netrin	P00359	NFAT	RAT|RGD=1310749|UniProtKB=D3Z9H7	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	ISS	9462517	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P06212	DPP-SCW signaling pathway	P06264	TLD	DROME|FlyBase=FBgn0003719|UniProtKB=P25723	Dorsal-ventral patterning protein tolloid	IDA	9759503	PubMed	PTHR43978:SF2	DORSAL-VENTRAL PATTERNING PROTEIN TOLLOID-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	BOVIN|Ensembl=ENSBTAG00000033153|UniProtKB=F1MG21	Uncharacterized protein	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000007445|UniProtKB=F6SWI4	Uncharacterized protein	ISS	20088160	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00005	Angiogenesis	P00234	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	9763606	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00018	EGF receptor signaling pathway	P00547	PP2A	DANRE|ZFIN=ZDB-GENE-050417-441|UniProtKB=Q567Y8	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00979	MAPKAPK2	MOUSE|MGI=MGI=109298|UniProtKB=P49138	MAP kinase-activated protein kinase 2	IC	8262198	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00057	Wnt signaling pathway	P01444	Wnt	DANRE|ZFIN=ZDB-GENE-990603-12|UniProtKB=O73864	Protein Wnt-11	IDA	8717036	PubMed	PTHR12027:SF34	PROTEIN WNT
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00012	Cadherin signaling pathway	P00477	GSK3beta	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00034	Integrin signalling pathway	P00916	Ras	DICPU|Gene=DICPUDRAFT_92731|UniProtKB=F0ZWE6	Putative uncharacterized protein rasG	ISS	89128893	PubMed	PTHR24070:SF282	RAS GTPASE-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TRIAD|EnsemblGenome=TriadG49626|UniProtKB=B3RKR4	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04393	Ras Pathway	P04547	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00019	Endothelin signaling pathway	P00586	Gq	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MONDO|Ensembl=ENSMODG00000001775|UniProtKB=F6WJB1	Uncharacterized protein	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	DANRE|Ensembl=ENSDARG00000015050|UniProtKB=Q6PI52	Calmodulin	ISS			PTHR23050:SF326	CALMODULIN
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05918	p38 MAPK pathway	P06034	MKK4	PANTR|Ensembl=ENSPTRG00000008783|UniProtKB=H2QCA7	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00029	Huntington disease	P00807	Actin	CHICK|Ensembl=ENSGALG00000028749|UniProtKB=Q5ZMQ2	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000025373|UniProtKB=F6ZZG9	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01457	GBeta	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00021	FGF signaling pathway	P00641	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	RCA	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	15621031	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00048	PI3 kinase pathway	P01181	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IPI	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	PANTR|Ensembl=ENSPTRG00000019406|UniProtKB=H2QUX9	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF26	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT GAMMA-T1
P00053	T cell activation	P01316	MHC-antigen	PANTR|Ensembl=ENSPTRG00000018028|UniProtKB=H2QSS3	Uncharacterized protein	ISS	73139	PubMed	PTHR19944:SF44	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DO ALPHA CHAIN
P04393	Ras Pathway	P04560	AP1	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00046	Oxidative stress response	P01135	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	TAS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00030	Hypoxia response via HIF activation	P00819	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01023	CaMKII	MACMU|Ensembl=ENSMMUG00000008587|UniProtKB=F6UGY3	Calcium/calmodulin-dependent protein kinase type II subunit delta isoform 3	ISS	12888804	PubMed	PTHR43940:SF4	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT DELTA
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MONDO|Ensembl=ENSMODG00000004799|UniProtKB=F6VM87	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00059	p53 pathway	P04612	HDAC1	RAT|RGD=1309799|UniProtKB=Q4QQW4	Histone deacetylase 1	ISS	10485845	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P04395	Vasopressin synthesis	P04597	Signal Peptide	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00021	FGF signaling pathway	P00632	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IGI	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00925	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IDA	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00049	Parkinson disease	P01211	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	21071228	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00029	Huntington disease	P00790	beta-Tubulin	STRPU|EnsemblGenome=SPU_002788|UniProtKB=W4XHC0	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P06664	Gonadotropin-releasing hormone receptor pathway	P06794	MAP2K1/2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	RCA	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00049	Parkinson disease	P01211	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	RAT|RGD=619966|UniProtKB=F1LQT1	Adenylate cyclase 7	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P02738	De novo purine biosynthesis	P02889	dGDP kinase	ORYSJ|EnsemblGenome=OS07G0492000|UniProtKB=Q07661	Nucleoside diphosphate kinase 1	ISS			PTHR11349:SF66	SUBFAMILY NOT NAMED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00750	Rhodopsin kinase	RAT|RGD=619712|UniProtKB=Q63651	Rhodopsin kinase	IDA	8288567	PubMed	PTHR24355:SF11	RHODOPSIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	MACMU|Ensembl=ENSMMUG00000004657|UniProtKB=G7MVY8	Furin	ISS	95328031	PubMed	PTHR42884:SF1	FURIN
P02759	Pyridoxal-5-phosphate biosynthesis	P03062	1-Deoxyxylulose-5-phosphate synthase	ARATH|TAIR=AT3G21500|UniProtKB=F4IXL8	1-deoxy-D-xylulose 5-phosphate synthase 1	ISS			PTHR43322:SF5	1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE 1-RELATED
P00036	Interleukin signaling pathway	P00983	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	BOVIN|Ensembl=ENSBTAG00000016420|UniProtKB=Q0VCX4	Catenin beta-1	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P00018	EGF receptor signaling pathway	P00552	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	BOVIN|Ensembl=ENSBTAG00000047856|UniProtKB=G3MZE2	Uncharacterized protein	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04547	Ras	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	IDA	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	PANTR|Ensembl=ENSPTRG00000008766|UniProtKB=H2QC97	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF504	MYOSIN-13
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000002775|UniProtKB=H2RB55	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00005	Angiogenesis	P00205	GAP	HUMAN|HGNC=9871|UniProtKB=P20936	Ras GTPase-activating protein 1	IDA	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	IC	2372396	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P02776	Serine glycine biosynthesis	P03159	Phosphoserine phosphatase	STRCO|Gene=CAB50876|UniProtKB=Q9S281	Phosphoserine phosphatase	ISS			PTHR43344:SF2	PHOSPHOSERINE PHOSPHATASE
P00010	B cell activation	P00383	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IDA	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00029	Huntington disease	P00778	NMDA receptor	MACMU|Ensembl=ENSMMUG00000001661|UniProtKB=F7GR69	Uncharacterized protein	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00056	VEGF signaling pathway	P01402	MEK	RAT|RGD=62087|UniProtKB=P27704	Mitogen-activated protein kinase 6	ISS			PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DANRE|ZFIN=ZDB-GENE-050417-267|UniProtKB=F1QUN8	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF263	ACTIN
P00048	PI3 kinase pathway	P01196	PDK1	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	IDA	15210700	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	ORNAN|Ensembl=ENSOANG00000004058|UniProtKB=F6TYP9	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04651	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00048	PI3 kinase pathway	P01192	p110	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00029	Huntington disease	P00787	MAPKK4	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00016	Cytoskeletal regulation by Rho GTPase	P00519	ROCK	ANOGA|EnsemblGenome=AGAP000406|UniProtKB=Q7PRV2	AGAP000406-PA	ISS			PTHR22988:SF38	RHO-ASSOCIATED PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	HUMAN|HGNC=9300|UniProtKB=P62714	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00011	Blood coagulation	P00417	TFPI	PANTR|Ensembl=ENSPTRG00000012723|UniProtKB=H2QJ44	Tissue factor pathway inhibitor (Lipoprotein-associated coagulation inhibitor)	ISS	6094466	gi	PTHR10083:SF311	TISSUE FACTOR PATHWAY INHIBITOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00034	Integrin signalling pathway	P00936	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	TAS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04393	Ras Pathway	P04557	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	IDA	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02726	Aminobutyrate degradation	P02824	Succinate semi-aldehyde dehydrogenase	RHOBA|EnsemblGenome=RB10968|UniProtKB=Q7UJY9	Succinate-semialdehyde dehydrogenase [NADP+]	ISS			PTHR43217:SF2	SUBFAMILY NOT NAMED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05941	GRK3	PANTR|Ensembl=ENSPTRG00000014187|UniProtKB=H2R714	Protein-serine/threonine kinase	ISS	10852916	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	ISS	12488551	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00010	B cell activation	P00391	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01457	GBeta	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	CHICK|Ensembl=ENSGALG00000009705|UniProtKB=F1NSR9	Uncharacterized protein	ISS	15226293	PubMed	PTHR13715:SF16	RYANODINE RECEPTOR 3
P00053	T cell activation	P01311	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00017	DNA replication	P00532	Hel	MACMU|Ensembl=ENSMMUG00000019705|UniProtKB=F7CAD7	Uncharacterized protein	RCA			PTHR10887:SF14	DNA REPLICATION ATP-DEPENDENT HELICASE/NUCLEASE DNA2
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00006	Apoptosis signaling pathway	P00274	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00046	Oxidative stress response	P01135	p38	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	4506785	gi	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00034	Integrin signalling pathway	P00944	Actin	MONDO|Ensembl=ENSMODG00000025240|UniProtKB=F7A7I3	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00015	Circadian clock system	G01497	cry	CANLF|Ensembl=ENSCAFG00000009379|UniProtKB=F1PNC9	Uncharacterized protein	ISS	11804325	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05925	beta-ARR1	BOVIN|Ensembl=ENSBTAG00000020485|UniProtKB=P17870	Beta-arrestin-1	RCA	9388255	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=1351341|UniProtKB=Q68EF4	Metabotropic glutamate receptor 4	ISS	12351712	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00019	Endothelin signaling pathway	P00591	PLCbeta	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04551	RalGDS	BOVIN|Ensembl=ENSBTAG00000019630|UniProtKB=F1N644	Uncharacterized protein	ISS			PTHR23113:SF199	RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 1
P00018	EGF receptor signaling pathway	P00547	PP2A	YEAST|SGD=S000002347|UniProtKB=P23595	Serine/threonine-protein phosphatase PP2A-2 catalytic subunit	ISS			PTHR11668:SF242	SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-1 CATALYTIC SUBUNIT-RELATED
P02776	Serine glycine biosynthesis	P03159	Phosphoserine phosphatase	RAT|RGD=1308764|UniProtKB=Q5M819	Phosphoserine phosphatase	ISS			PTHR43344:SF2	PHOSPHOSERINE PHOSPHATASE
P00018	EGF receptor signaling pathway	P00552	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IGI	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=1351340|UniProtKB=Q9QYS2	Metabotropic glutamate receptor 3	IDA	9407094	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00034	Integrin signalling pathway	P00948	Rho	BOVIN|Ensembl=ENSBTAG00000046054|UniProtKB=Q3ZBW5	Rho-related GTP-binding protein RhoB	ISS	13679859	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00005	Angiogenesis	P00223	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P02751	Lysine biosynthesis	P03006	Dihydrodipicolinate  reductase	AQUAE|EnsemblGenome=aq_916|UniProtKB=O67061	4-hydroxy-tetrahydrodipicolinate reductase	ISS			PTHR20836:SF0	DIHYDRODIPICOLINATE REDUCTASE-LIKE PROTEIN CRR1, CHLOROPLASTIC
P02784	Tyrosine biosynthesis	P03214	Prephenate dehydrogenase	DEIRA|EnsemblGenome=DR_1122|UniProtKB=Q9RVA7	Prephenate dehydrogenase	ISS			PTHR21363:SF0	PREPHENATE DEHYDROGENASE  NADP +
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00005	Angiogenesis	P00219	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00021	FGF signaling pathway	P00627	ERK1-2	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	BOVIN|Gene=KCNJ5|UniProtKB=F1MYR9	G protein-activated inward rectifier potassium channel 4	ISS	12374786	PubMed	PTHR11767:SF52	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MOUSE|MGI=MGI=87887|UniProtKB=Q8R4G9	Neuronal acetylcholine receptor subunit alpha-3	IC	85270494	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00049	Parkinson disease	P01218	alpha-Synuclein	PANTR|Ensembl=ENSPTRG00000016282|UniProtKB=P61145	Alpha-synuclein	ISS	9278044	PubMed	PTHR13820:SF5	ALPHA-SYNUCLEIN
P00012	Cadherin signaling pathway	P00474	Wnt	CHICK|Ensembl=ENSGALG00000014235|UniProtKB=Q3L254	Protein Wnt-7b	ISS	8717036	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00021	FGF signaling pathway	P00641	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IGI	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	ANOGA|EnsemblGenome=AGAP001506|UniProtKB=Q7PXP3	AGAP001506-PA	IC			PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00057	Wnt signaling pathway	P01430	p53	PANTR|Ensembl=ENSPTRG00000008703|UniProtKB=H2QC53	Cellular tumor antigen p53	ISS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00003	Alzheimer disease-amyloid secretase pathway	P00093	Tip60	PANTR|Ensembl=ENSPTRG00000003890|UniProtKB=H2Q441	Histone acetyltransferase	ISS	11441186	PubMed	PTHR10615:SF124	HISTONE ACETYLTRANSFERASE KAT5
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=1354946|UniProtKB=Q61532	Mitogen-activated protein kinase 6	IC	8444355	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	ISS	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00049	Parkinson disease	P01211	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	IDA	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CAEBR|Gene=CBG18256|UniProtKB=A8XS95	Protein CBR-ACT-5	ISS	11889126	PubMed	PTHR11937:SF352	ACTIN
P00005	Angiogenesis	P00200	Dsh	HUMAN|HGNC=3087|UniProtKB=Q92997	Segment polarity protein dishevelled homolog DVL-3	ISS	10409711	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P00019	Endothelin signaling pathway	P00572	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CAEBR|Gene=CBG02162|UniProtKB=A8WS33	Protein CBG02162	ISS	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00018	EGF receptor signaling pathway	P00555	MKK4,7	BOVIN|Ensembl=ENSBTAG00000012103|UniProtKB=A5PJP8	MAP2K4 protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00046	Oxidative stress response	P01131	MKP5	MACMU|Ensembl=ENSMMUG00000018514|UniProtKB=F7A8S7	Dual specificity protein phosphatase 22	ISS			PTHR10159:SF29	DUAL SPECIFICITY PROTEIN PHOSPHATASE 22
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02749	Leucine biosynthesis	P02999	2-Isopropylmalate synthase	METAC|EnsemblGenome=MA_3342|UniProtKB=Q8TKQ6	Putative homocitrate synthase AksA	ISS			PTHR10277:SF9	2-ISOPROPYLMALATE SYNTHASE 1, CHLOROPLASTIC-RELATED
P00005	Angiogenesis	P00243	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00627	ERK1-2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	HUMAN|HGNC=704|UniProtKB=O15143	Actin-related protein 2/3 complex subunit 1B	ISS	9618202	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00020	FAS signaling pathway	P00593	Caspase9	HUMAN|HGNC=1511|UniProtKB=P55211	Caspase-9	IGI	8663294	PubMed	PTHR10454:SF157	CASPASE-9
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	PANTR|Ensembl=ENSPTRG00000013147|UniProtKB=H2QJS7	Uncharacterized protein	ISS	10806215	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00010	B cell activation	P00402	Jnk	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	NEUCR|EnsemblGenome=EFNCRG00000002605|UniProtKB=Q9UW15	Ribonucleoside-diphosphate reductase large chain	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01219	SAPK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00017	DNA replication	P00531	Pol alpha	HUMAN|HGNC=9173|UniProtKB=P09884	DNA polymerase alpha catalytic subunit	ISS	20009599	PubMed	PTHR10322:SF21	DNA POLYMERASE ALPHA CATALYTIC SUBUNIT
P00029	Huntington disease	P00788	Calpain	CHICK|Gene=CAPN2|UniProtKB=Q92178	Calpain-2 catalytic subunit	IDA	11675509	PubMed	PTHR10183:SF268	CALPAIN-2 CATALYTIC SUBUNIT
P00010	B cell activation	P00367	NFAT	BOVIN|Ensembl=ENSBTAG00000004368|UniProtKB=F1MSU2	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00047	PDGF signaling pathway	P01143	ERK	BOVIN|Ensembl=ENSBTAG00000004216|UniProtKB=F1MSX4	Uncharacterized protein	ISS			PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	TAS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00006	Apoptosis signaling pathway	P00294	RAIDD	MOUSE|MGI=MGI=1336168|UniProtKB=O88843	Death domain-containing protein CRADD	ISS	8985253	PubMed	PTHR15034:SF5	DEATH DOMAIN-CONTAINING PROTEIN CRADD
P00021	FGF signaling pathway	P00629	PP2A	ORNAN|Ensembl=ENSOANG00000005732|UniProtKB=F6X0X1	Uncharacterized protein	ISS	8576224	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00562	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	ISS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	DROME|FlyBase=FBgn0015024|UniProtKB=P54367	Casein kinase I isoform alpha	IDA	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00057	Wnt signaling pathway	P01447	Dishevelled	PANTR|Ensembl=ENSPTRG00000015681|UniProtKB=H2QNU7	Dishevelled, dsh homolog 3	ISS	11212302	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01444	Wnt	CHICK|Ensembl=ENSGALG00000004790|UniProtKB=P49337	Protein Wnt-4	IDA	8717036	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	MACMU|Ensembl=ENSMMUG00000012033|UniProtKB=F7GWI2	Serine/threonine-protein kinase PAK 2	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00029	Huntington disease	G01532	PolyQ HTT	RAT|RGD=68337|UniProtKB=P51111	Huntingtin	TAS	8268927	PubMed	PTHR10170:SF10	HUNTINGTIN
P00057	Wnt signaling pathway	P01451	Galpha	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00057	Wnt signaling pathway	P01430	p53	MOUSE|MGI=MGI=98834|UniProtKB=P02340	Cellular tumor antigen p53	IDA	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00012	Cadherin signaling pathway	P00465	TCF/LEF	MOUSE|MGI=MGI=1202879|UniProtKB=Q924A0	Transcription factor 7-like 2	ISS	9118222	PubMed	PTHR10373:SF32	TRANSCRIPTION FACTOR 7-LIKE 2
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	HUMAN|HGNC=132|UniProtKB=P60709	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	PANTR|Ensembl=ENSPTRG00000016383|UniProtKB=H2QQ24	Calcium/calmodulin-dependent protein kinase II delta	ISS	12888804	PubMed	PTHR43940:SF4	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT DELTA
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DICDI|dictyBase=DDB_G0269234|UniProtKB=P07830	Major actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	RAT|RGD=1306213|UniProtKB=D3ZQ51	Protein Pak6	ISS			PTHR24361:SF182	SERINE/THREONINE-PROTEIN KINASE PAK 6
P00018	EGF receptor signaling pathway	P00551	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00641	SOS	CHICK|Ensembl=ENSGALG00000013224|UniProtKB=F1NMA4	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	XENTR|Xenbase=XB-GENE-957248|UniProtKB=Q6GLE6	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00539	14-3-3	DROME|FlyBase=FBgn0020238|UniProtKB=P92177	14-3-3 protein epsilon	IGI	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00053	T cell activation	P01307	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IPI	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04397	p53 pathway by glucose deprivation	P04641	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MOUSE|MGI=MGI=2150393|UniProtKB=Q91ZU9	Glutamate receptor ionotropic, NMDA 3B	ISS	11319238	PubMed	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P00046	Oxidative stress response	P01135	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00048	PI3 kinase pathway	P01178	Grb2	CAEBR|Gene=CBG16856|UniProtKB=A8XPY6	Protein CBR-SEM-5	ISS	17569445	gi	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00629	PP2A	CANLF|Ensembl=ENSCAFG00000014047|UniProtKB=F1PV54	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00302	ATF	MONDO|Ensembl=ENSMODG00000009514|UniProtKB=F7EVK3	Uncharacterized protein	ISS	15218628	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ARATH|TAIR=AT1G53510|UniProtKB=Q9C5C0	Mitogen-activated protein kinase 18	IDA			PTHR24055:SF200	MITOGEN-ACTIVATED PROTEIN KINASE 18-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00857	IkappaB	RAT|RGD=3171|UniProtKB=Q63746	NF-kappa-B inhibitor alpha	ISS	14665694	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	STRPU|EnsemblGenome=SPU_007425|UniProtKB=W4XVG9	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00005	Angiogenesis	P00193	SOS-1	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	ORYSJ|Gene=Os01g0198200|UniProtKB=Q5QMY9	Os01g0198200 protein	IDA	11437445	PubMed	PTHR11909:SF288	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=621089|UniProtKB=F1LMI3	Cadherin 3, type 1, P-cadherin (Placental)	ISS	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P00020	FAS signaling pathway	P00610	MKK4	BOVIN|Ensembl=ENSBTAG00000012103|UniProtKB=A5PJP8	MAP2K4 protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00049	Parkinson disease	P01227	20S proteasome	ANOGA|EnsemblGenome=AGAP008816|UniProtKB=Q7PPM9	Proteasome subunit alpha type	TAS	12859888	PubMed	PTHR11599:SF14	PROTEASOME SUBUNIT ALPHA TYPE-5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	RAT|RGD=1304556|UniProtKB=P63259	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00054	Toll receptor signaling pathway	P01357	MEKK1	PANTR|Ensembl=ENSPTRG00000016891|UniProtKB=H2R5K3	Uncharacterized protein	ISS	12168099	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IDA	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00054	Toll receptor signaling pathway	P01355	AP1	XENTR|Xenbase=XB-GENE-482228|UniProtKB=F6RYL1	Uncharacterized protein	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P06587	Nicotine pharmacodynamics pathway	P06604	SLC18A2	RAT|RGD=3694|UniProtKB=Q01827	Synaptic vesicular amine transporter	TAS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000010143|UniProtKB=F6QXA9	Uncharacterized protein	ISS	11554554	PubMed	PTHR24356:SF175	SERINE/THREONINE-PROTEIN KINASE N3
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00034	Integrin signalling pathway	P00924	Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	IPI	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	RAT|RGD=62029|UniProtKB=P02563	Myosin-6	IC	10938134	PubMed	PTHR13140:SF721	MYOSIN-6
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P06664	Gonadotropin-releasing hormone receptor pathway	P06794	MAP2K1/2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	RCA	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02746	Heme biosynthesis	P02983	Hydroxymethylbilane synthase	FUSNN|EnsemblGenome=FN0645|UniProtKB=Q8RFP5	Porphobilinogen deaminase	ISS			PTHR11557:SF0	PORPHOBILINOGEN DEAMINASE
P00018	EGF receptor signaling pathway	P00551	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9441|UniProtKB=P51817	cAMP-dependent protein kinase catalytic subunit PRKX	IC	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	TAKRU|Ensembl=ENSTRUG00000005608|UniProtKB=H2SM93	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	TAKRU|Ensembl=ENSTRUG00000006307|UniProtKB=H2SSM1	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IDA	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00005	Angiogenesis	P00223	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	DROME|FlyBase=FBgn0005614|UniProtKB=P48994	Transient-receptor-potential-like protein	IDA	11055438	PubMed	PTHR10117:SF47	TRANSIENT-RECEPTOR-POTENTIAL-LIKE PROTEIN
P02746	Heme biosynthesis	P02983	Hydroxymethylbilane synthase	CANAL|CGD=CAL0000176208|UniProtKB=O94048	Porphobilinogen deaminase	ISS			PTHR11557:SF0	PORPHOBILINOGEN DEAMINASE
P00045	Notch signaling pathway	P01104	Serrate	MACMU|Ensembl=ENSMMUG00000018116|UniProtKB=F7FGM9	Delta-like protein	ISS	10551863	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00030	Hypoxia response via HIF activation	P00823	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00048	PI3 kinase pathway	P01188	Gbetagamma	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00029	Huntington disease	P00797	p53	BOVIN|Ensembl=ENSBTAG00000001069|UniProtKB=P67939	Cellular tumor antigen p53	TAS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00049	Parkinson disease	P01230	Src kinase	RAT|RGD=2994|UniProtKB=Q01621	Proto-oncogene tyrosine-protein kinase LCK	ISS	1505025	PubMed	PTHR24418:SF39	TYROSINE-PROTEIN KINASE LCK
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00550	Grb2	CAEEL|WormBase=WBGene00004774|UniProtKB=P29355	Sex muscle abnormal protein 5	IGI	51702266	gi	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00056	VEGF signaling pathway	P01407	Erk	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	RAT|RGD=61863|UniProtKB=P19493	Glutamate receptor 4	ISS	10331083	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	SCHPO|PomBase=SPAC806.07|UniProtKB=P49740	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	HUMAN|HGNC=17175|UniProtKB=Q9P212	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	15611108	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00562	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IGI	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	HUMAN|HGNC=7170|UniProtKB=O75900	Matrix metalloproteinase-23	TAS	12834808	PubMed	PTHR10201:SF7	MATRIX METALLOPROTEINASE-23
P00047	PDGF signaling pathway	P01161	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01311	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00048	PI3 kinase pathway	P01199	Galpha	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS			PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04561	SRF	RAT|RGD=1559787|UniProtKB=D3ZHH8	Protein Srf	ISS	15647354	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT2G18170|UniProtKB=Q39027	Mitogen-activated protein kinase 7	ISS	12787066	PubMed	PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00029	Huntington disease	P00786	ARF	CRYNJ|EnsemblGenome=CNG03220|UniProtKB=P0CM16	ADP-ribosylation factor	ISS	12932731	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	DANRE|ZFIN=ZDB-GENE-040718-414|UniProtKB=D7RVR6	Excitatory amino acid transporter SLC1A1	ISS	96032356	PubMed	PTHR11958:SF69	EXCITATORY AMINO ACID TRANSPORTER 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IC	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF330	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00975	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	88318957	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MONDO|Ensembl=ENSMODG00000000771|UniProtKB=F6SSS3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000012036|UniProtKB=F7ALP1	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P02721	ATP synthesis	P02791	F1 alpha	RAT|RGD=619993|UniProtKB=P15999	ATP synthase subunit alpha, mitochondrial	ISS	2527557	PubMed	PTHR43089:SF3	ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL
P00048	PI3 kinase pathway	P01200	SHIP	HUMAN|HGNC=6080|UniProtKB=O15357	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	IDA	10610720	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00046	Oxidative stress response	P01121	MKK3/6	MOUSE|MGI=MGI=1346868|UniProtKB=O09110	Dual specificity mitogen-activated protein kinase kinase 3	TAS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00053	T cell activation	P01305	Calmodulin	BRAFL|Gene=BRAFLDRAFT_87235|UniProtKB=C3ZEV9	Putative uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00006	Apoptosis signaling pathway	P00321	HSP70	MONDO|Ensembl=ENSMODG00000003386|UniProtKB=F6Z1G9	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF210	HEAT SHOCK 70 KDA PROTEIN 1-LIKE
P04393	Ras Pathway	P04553	PAK	PANTR|Ensembl=ENSPTRG00000022187|UniProtKB=Q7YQL4	Serine/threonine-protein kinase PAK 3	ISS	11259591	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000017387|UniProtKB=E2RLD1	Uncharacterized protein	ISS	129387	gi	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ARATH|TAIR=AT3G14720|UniProtKB=Q9LUC3	Mitogen-activated protein kinase 19	IDA			PTHR24055:SF200	MITOGEN-ACTIVATED PROTEIN KINASE 18-RELATED
P00019	Endothelin signaling pathway	P00586	Gq	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00009	Axon guidance mediated by netrin	P00359	NFAT	HUMAN|HGNC=7777|UniProtKB=Q12968	Nuclear factor of activated T-cells, cytoplasmic 3	IDA	12015605	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MOUSE|MGI=MGI=95819|UniProtKB=P35438	Glutamate receptor ionotropic, NMDA 1	IC	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04398	p53 pathway feedback loops 2	P04665	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00225	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	RCA			PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00036	Interleukin signaling pathway	P00990	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	ARATH|TAIR=AT1G08700|UniProtKB=O64668	Presenilin-like protein At1g08700	TAS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PHYPA|Gene=PHYPADRAFT_109052|UniProtKB=A9TZ58	Actin 5	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	RAT|RGD=619788|UniProtKB=Q99N78	Protein Trpc6	IDA	11055438	PubMed	PTHR10117:SF7	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 6
P00019	Endothelin signaling pathway	P00566	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00049	Parkinson disease	P01219	SAPK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000002339|UniProtKB=H2R368	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01174	Rho	PANTR|Ensembl=ENSPTRG00000017362|UniProtKB=H2QRP5	Rho GTPase activating protein 26	ISS	8649427	PubMed	PTHR12552:SF4	RHO GTPASE-ACTIVATING PROTEIN 26
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PHYIT|EnsemblGenome=PITG_15078|UniProtKB=D0NRL5	Actin-like protein	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00018	EGF receptor signaling pathway	P00562	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	ISS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00034	Integrin signalling pathway	P00944	Actin	PUCGT|EnsemblGenome=PGTG_05488|UniProtKB=E3K4I1	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00048	PI3 kinase pathway	P01202	p85	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00005	Angiogenesis	P00199	JNKK1	MOUSE|MGI=MGI=1346869|UniProtKB=P47809	Dual specificity mitogen-activated protein kinase kinase 4	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	BOVIN|Ensembl=ENSBTAG00000008195|UniProtKB=Q29RI2	Phosphorylase kinase, gamma 1 (Muscle)	ISS	1370475	PubMed	PTHR44087:SF1	PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, SKELETAL MUSCLE/HEART ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02738	De novo purine biosynthesis	P02905	Amidophosphoribosyl transferase	HALSA|EnsemblGenome=VNG_1493G|UniProtKB=Q9HPS4	Amidophosphoribosyltransferase	ISS			PTHR11907:SF0	AMIDOPHOSPHORIBOSYLTRANSFERASE
P05917	Opioid proopiomelanocortin pathway	P06009	K+ channel	MACMU|Ensembl=ENSMMUG00000005826|UniProtKB=F6VE51	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	CHICK|Ensembl=ENSGALG00000006576|UniProtKB=E1BUE5	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00029	Huntington disease	P00801	Fos protein	PANTR|Ensembl=ENSPTRG00000006553|UniProtKB=A5A6H0	C-fos	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00005	Angiogenesis	P00203	Erk	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00059	p53 pathway	P01486	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	TAS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05916	Opioid prodynorphin pathway	P06002	G-protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00260	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00011	Blood coagulation	P00429	PN2	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	ISS	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MACMU|Gene=CHRM1|UniProtKB=P56489	Muscarinic acetylcholine receptor M1	TAS	12181435	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01212	p38 MAPK	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	NAS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04398	p53 pathway feedback loops 2	P04658	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CANLF|Ensembl=ENSCAFG00000009203|UniProtKB=F1PVZ1	Muscarinic acetylcholine receptor	ISS	91373358	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00034	Integrin signalling pathway	P00936	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	G01511	SPRY	BOVIN|Ensembl=ENSBTAG00000008250|UniProtKB=A2VDU1	Protein sprouty homolog 4	ISS	22024232	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P00019	Endothelin signaling pathway	P00591	PLCbeta	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MONDO|Ensembl=ENSMODG00000018204|UniProtKB=F6PGX6	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00057	Wnt signaling pathway	P01452	NFAT	PANTR|Ensembl=ENSPTRG00000006218|UniProtKB=H2Q834	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00012	Cadherin signaling pathway	P00470	F-actin	TRIAD|EnsemblGenome=TriadG63375|UniProtKB=B3S5E4	Non-muscle actin 6.2	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00006	Apoptosis signaling pathway	P00274	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00034	Integrin signalling pathway	P00907	ERK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS			PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05918	p38 MAPK pathway	P06043	ASK1	MOUSE|MGI=MGI=1346876|UniProtKB=O35099	Mitogen-activated protein kinase kinase kinase 5	TAS	8974401	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P05731	GABA-B receptor II signaling	P05754	Ggamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00029	Huntington disease	P00781	Dynactin	MONDO|Ensembl=ENSMODG00000005141|UniProtKB=F7EQF1	Uncharacterized protein	ISS	9454836	PubMed	PTHR18916:SF40	DYNACTIN SUBUNIT 1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	EMENI|EnsemblGenome=CADANIAG00006296|UniProtKB=Q5ASG1	Putative synaptobrevin homologue SNC1/2 (Eurofung)	ISS			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00054	Toll receptor signaling pathway	P01352	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02738	De novo purine biosynthesis	P02889	dGDP kinase	MACMU|Ensembl=ENSMMUG00000003857|UniProtKB=F7HA84	Nucleoside diphosphate kinase	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P00005	Angiogenesis	P00190	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	14707121	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00057	Wnt signaling pathway	P01444	Wnt	CHICK|Gene=WNT2B|UniProtKB=Q98SN7	Protein Wnt-2b	IDA	11266476	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TAKRU|Ensembl=ENSTRUG00000005494|UniProtKB=P53483	Actin, alpha anomalous	IC	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	10802295	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	BACSU|EnsemblGenome=BSU13170|UniProtKB=O34598	Guanine deaminase	ISS			PTHR44192:SF2	SUBFAMILY NOT NAMED
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	MOUSE|MGI=MGI=2159601|UniProtKB=Q920N7	Synaptotagmin-12	ISS			PTHR10024:SF252	SYNAPTOTAGMIN-12
P00024	Glycolysis	P00679	Aldolase	MOUSE|MGI=MGI=87994|UniProtKB=P05064	Fructose-bisphosphate aldolase A	ISS	84261525	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P05914	Nicotine degradation	P05979	FMO3	MOUSE|MGI=MGI=1100496|UniProtKB=P97501	Dimethylaniline monooxygenase [N-oxide-forming] 3	ISS			PTHR23023:SF44	DIMETHYLANILINE MONOOXYGENASE  N-OXIDE-FORMING  3
P05918	p38 MAPK pathway	P06035	TAB1	MOUSE|MGI=MGI=1913763|UniProtKB=Q8CF89	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1	ISS	10838074	PubMed	PTHR13832:SF533	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1
P00059	p53 pathway	G04694	p110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04558	p38	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	IDA	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IDA	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01428	Frizzled	RAT|RGD=1560525|UniProtKB=Q498S8	Frizzled-8	ISS	11212302	PubMed	PTHR11309:SF90	FRIZZLED-8
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_188187|UniProtKB=E9GJ31	Guanine nucleotide binding protein, q polypeptide	ISS	14765990	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00052	TGF-beta signaling pathway	P01286	TGFbeta	ANOGA|EnsemblGenome=AGAP000824|UniProtKB=Q7PNK1	AGAP000824-PA	TAS	9759503	PubMed	PTHR11848:SF54	PROTEIN 60A-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	RAT|RGD=2523|UniProtKB=P25115	D(1B) dopamine receptor	ISS	11861492	PubMed	PTHR43893:SF8	D 1B  DOPAMINE RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	PANTR|Ensembl=ENSPTRG00000001112|UniProtKB=H2PZP2	Ras homolog gene family, member C	ISS	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00004	Alzheimer disease-presenilin pathway	P00114	actin	EMENI|EnsemblGenome=CADANIAG00007315|UniProtKB=P20359	Actin, gamma	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00019	Endothelin signaling pathway	P00588	ET1-4	RAT|RGD=2533|UniProtKB=P23943	Endothelin-2	ISS	8201007	PubMed	PTHR13874:SF9	ENDOTHELIN-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	IDA	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00053	T cell activation	P01305	Calmodulin	CANLF|Ensembl=ENSCAFG00000017516|UniProtKB=E2REK6	Uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF311	CALMODULIN
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	RAT|RGD=69430|UniProtKB=P32851	Syntaxin-1A	IC	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04556	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01465	Ggamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00629	PP2A	DANRE|ZFIN=ZDB-GENE-040426-2487|UniProtKB=Q803G3	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MACMU|Ensembl=ENSMMUG00000009287|UniProtKB=F7H3T9	Glutamate receptor 1 isoform 1	ISS	12871085	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05934	ELK1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	RCA	14670631	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P05918	p38 MAPK pathway	P06034	MKK4	CANLF|Ensembl=ENSCAFG00000017851|UniProtKB=F1PBB6	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00060	Ubiquitin proteasome pathway	P01491	E2	DANRE|ZFIN=ZDB-GENE-030131-6065|UniProtKB=Q7ZVK2	Ubiquitin-conjugating enzyme E2G 2	ISS			PTHR24067:SF172	UBIQUITIN-CONJUGATING ENZYME E2G 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	MOUSE|MGI=MGI=107191|UniProtKB=P36898	Bone morphogenetic protein receptor type-1B	TAS	9395284	PubMed	PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P00048	PI3 kinase pathway	P01181	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04393	Ras Pathway	P04567	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000025240|UniProtKB=F7A7I3	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	HUMAN|HGNC=17175|UniProtKB=Q9P212	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	7822322	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00029	Huntington disease	P00774	Dynein complex	PANTR|Ensembl=ENSPTRG00000004224|UniProtKB=H2RCI9	Uncharacterized protein	ISS	9454836	PubMed	PTHR10676:SF352	CYTOPLASMIC DYNEIN 2 HEAVY CHAIN 1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	XENTR|Xenbase=XB-GENE-479567|UniProtKB=A4ZGP0	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P00048	PI3 kinase pathway	P01177	P110ACT	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00623	FGF	CANLF|Ensembl=ENSCAFG00000029890|UniProtKB=J9P0B3	Fibroblast growth factor	ISS			PTHR11486:SF28	FIBROBLAST GROWTH FACTOR 9
P00006	Apoptosis signaling pathway	P00310	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00641	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00384	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	ISS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MOUSE|MGI=MGI=1336171|UniProtKB=Q9DAS9	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MACMU|Ensembl=ENSMMUG00000001353|UniProtKB=F7D6T8	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02748	Isoleucine biosynthesis	P02998	Dihydroxyacid dehydratase	STRCO|Gene=CAB61588|UniProtKB=Q9RJZ4	Putative dihydroxy-acid dehydratase	ISS			PTHR43183:SF3	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	CANLF|Ensembl=ENSCAFG00000029969|UniProtKB=J9P4G6	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF184	REGULATOR OF G-PROTEIN SIGNALING 4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04560	AP1	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	8837781	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	HUMAN|HGNC=9509|UniProtKB=P49810	Presenilin-2	TAS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	HUMAN|HGNC=5184|UniProtKB=Q9Y5N1	Histamine H3 receptor	IDA			PTHR44152:SF4	HISTAMINE H3 RECEPTOR
P02738	De novo purine biosynthesis	P02907	dADP kinase	PANTR|Ensembl=ENSPTRG00000001655|UniProtKB=H2Q0K0	Non-metastatic cells 7, protein expressed in (Nucleoside-diphosphate kinase)	ISS			PTHR43109:SF2	NUCLEOSIDE DIPHOSPHATE KINASE 7
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04580	TRH Receptor	MONDO|Ensembl=ENSMODG00000004935|UniProtKB=F7AUF1	Uncharacterized protein	ISS	14599121	PubMed	PTHR24243:SF115	THYROTROPIN-RELEASING HORMONE RECEPTOR
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8971|UniProtKB=O00443	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00010	B cell activation	P00373	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P02740	De novo pyrimidine ribonucleotides biosythesis	P02927	Dihydrooratate oxidase	STRCO|EnsemblGenome=CAB93362|UniProtKB=Q9KXR7	Dihydroorotate dehydrogenase (quinone)	ISS			PTHR43517:SF1	DIHYDROOROTATE DEHYDROGENASE  QUINONE , MITOCHONDRIAL
P00049	Parkinson disease	P01224	UbcH7	MOUSE|MGI=MGI=109240|UniProtKB=P68037	Ubiquitin-conjugating enzyme E2 L3	RCA			PTHR24068:SF67	UBIQUITIN-CONJUGATING ENZYME E2 L3
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00057	Wnt signaling pathway	P01443	Phospholipase C	CAEEL|WormBase=WBGene00004037|UniProtKB=Q9XWB7	Phosphoinositide phospholipase C	IDA	12860966	PubMed	PTHR10336:SF9	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	BOVIN|Ensembl=ENSBTAG00000012687|UniProtKB=F1MV64	Tyrosine-protein kinase receptor	ISS	11182407	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00048	PI3 kinase pathway	P01179	PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02747	Histidine biosynthesis	P02984	Imidazol glycerol phosphate dehydratase	AQUAE|EnsemblGenome=aq_039|UniProtKB=O66455	Imidazoleglycerol-phosphate dehydratase	ISS			PTHR23133:SF2	IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE
P04398	p53 pathway feedback loops 2	P04651	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IDA	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	BOVIN|Ensembl=ENSBTAG00000004305|UniProtKB=O46471	Regulator of G-protein signaling 16	IDA	8756726	PubMed	PTHR10845:SF187	REGULATOR OF G-PROTEIN SIGNALING 16
P00029	Huntington disease	P00807	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g169611|UniProtKB=A7SEB1	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04393	Ras Pathway	P04567	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02913	Thymidylate synthase	MOUSE|MGI=MGI=98878|UniProtKB=P07607	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P05913	Enkephalin release	P05974	G-Protein (i)	XENTR|Xenbase=XB-GENE-6050844|UniProtKB=F6WNJ9	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000014807|UniProtKB=F6W548	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00012	Cadherin signaling pathway	P00477	GSK3beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	CANLF|Ensembl=ENSCAFG00000011625|UniProtKB=F1PDD9	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Ensembl=ENSPTRG00000017441|UniProtKB=H2QRU7	Glutamate receptor, ionotropic, AMPA 1	ISS	12871085	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00037	Ionotropic glutamate receptor pathway	P01021	Vglut	BOVIN|Ensembl=ENSBTAG00000038347|UniProtKB=A6QLI1	Vesicular glutamate transporter 2	ISS	12815758	PubMed	PTHR11662:SF201	VESICULAR GLUTAMATE TRANSPORTER 2
P00021	FGF signaling pathway	P00637	MKK4,7	DROME|FlyBase=FBgn0024326|UniProtKB=O61444	MAP kinase kinase 4, isoform A	NAS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	DANRE|ZFIN=ZDB-GENE-051202-1|UniProtKB=E7F101	Uncharacterized protein	ISS	92049750	PubMed	PTHR44391:SF2	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	HUMAN|HGNC=3826|UniProtKB=P21462	fMet-Leu-Phe receptor	ISS	7305065	gi	PTHR24225:SF15	FMET-LEU-PHE RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04398	p53 pathway feedback loops 2	P04665	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	HUMAN|HGNC=9299|UniProtKB=P67775	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00639	Shc	MOUSE|MGI=MGI=106179|UniProtKB=Q61120	SHC-transforming protein 3	IDA	12006576	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P04384	Gamma-aminobutyric acid synthesis	P04481	Succinic semialdehyde dehydrogenase	PANTR|Gene=ALDH5A1|UniProtKB=Q6A2H0	Succinate-semialdehyde dehydrogenase, mitochondrial	IC	12891648	PubMed	PTHR43353:SF5	SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL
P00003	Alzheimer disease-amyloid secretase pathway	P00090	MDC9	PANTR|Ensembl=ENSPTRG00000020182|UniProtKB=H2QW21	ADAM metallopeptidase domain 9	ISS	10510302	PubMed	PTHR11905:SF136	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 9
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MOUSE|MGI=MGI=96274|UniProtKB=P28334	5-hydroxytryptamine receptor 1B	ISS	11454663	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P00018	EGF receptor signaling pathway	P00564	Rac	PHYPA|Gene=PHYPADRAFT_170715|UniProtKB=A9TLC7	Rop-family small GTPase	IGI			PTHR24072:SF194	RAC-LIKE GTP-BINDING PROTEIN ARAC4-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00011	Blood coagulation	P00431	tPA	MACMU|Ensembl=ENSMMUG00000014432|UniProtKB=F7BHV7	Tissue-type plasminogen activator	ISS	6572897	PubMed	PTHR44617:SF1	TISSUE-TYPE PLASMINOGEN ACTIVATOR
P00047	PDGF signaling pathway	P01154	Ras	CAEEL|WormBase=WBGene00008672|UniProtKB=O17789	Uncharacterized protein	ISS			PTHR24073:SF354	RAS-RELATED PROTEIN RAB-2A
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00036	Interleukin signaling pathway	P00996	STAT	MONDO|Ensembl=ENSMODG00000014816|UniProtKB=F7CHH2	Signal transducer and activator of transcription	ISS	14662325	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00561	STAT	PANTR|Ensembl=ENSPTRG00000005121|UniProtKB=H2Q6A5	Uncharacterized protein	ISS	8085155	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00005	Angiogenesis	P00230	PDGFR	RAT|RGD=3285|UniProtKB=Q05030	Platelet-derived growth factor receptor beta	ISS			PTHR24416:SF53	PLATELET-DERIVED GROWTH FACTOR RECEPTOR BETA
P05916	Opioid prodynorphin pathway	P06002	G-protein	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DANRE|ZFIN=ZDB-GENE-040426-1354|UniProtKB=Q7T2C5	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00507	Rho	CAEBR|Gene=CBG13664|UniProtKB=A8XIF5	Protein CBR-RHO-1	ISS	11973360	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00899	IRS 1-4	BOVIN|Ensembl=ENSBTAG00000021308|UniProtKB=F1MYE0	Uncharacterized protein	ISS	1311924	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00018	EGF receptor signaling pathway	P00564	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	8649368	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01286	TGFbeta	XENTR|Xenbase=XB-GENE-481829|UniProtKB=Q90YD7	BMP-2	ISS	9759503	PubMed	PTHR11848:SF143	BONE MORPHOGENETIC PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	TRYB2|Gene=Tb10.70.0830|UniProtKB=Q38B01	Clathrin heavy chain	ISS	9388255	PubMed	PTHR10292:SF1	CLATHRIN HEAVY CHAIN
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	CANLF|Ensembl=ENSCAFG00000025220|UniProtKB=E2R174	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF66	SERINE/THREONINE-PROTEIN KINASE RECEPTOR R3
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05913	Enkephalin release	P05974	G-Protein (i)	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	RAT|RGD=3694|UniProtKB=Q01827	Synaptic vesicular amine transporter	ISS	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00019	Endothelin signaling pathway	P00566	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00368	vav	PANTR|Ensembl=ENSPTRG00000010378|UniProtKB=H2QF58	Uncharacterized protein	ISS	14623913	PubMed	PTHR22826:SF112	PROTO-ONCOGENE VAV
P00005	Angiogenesis	P00182	p38MAPK	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	RAT|RGD=2027|UniProtKB=P63269	Actin, gamma-enteric smooth muscle	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00038	JAK/STAT signaling pathway	P01027	STAT	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	14755057	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MACMU|Ensembl=ENSMMUG00000015709|UniProtKB=F6SLX4	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	XENTR|Xenbase=XB-GENE-490883|UniProtKB=Q6NVA9	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04542	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01413	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	ISS	12660731	PubMed	PTHR10048:SF14	PI-3 KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PANTR|Ensembl=ENSPTRG00000009762|UniProtKB=H2QE24	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CHICK|Ensembl=ENSGALG00000012894|UniProtKB=P30372	Muscarinic acetylcholine receptor M2	IDA	8100450	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00034	Integrin signalling pathway	P00920	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	IPI	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	RCA	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00021	FGF signaling pathway	P00645	Rac	CAEBR|Gene=CBG17302|UniProtKB=A8XQS8	Protein CBR-MIG-2	ISS			PTHR24072:SF157	AT17867P
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00017	DNA replication	P00529	RFC	RAT|RGD=1306832|UniProtKB=Q5M830	Protein Rfc3	RCA			PTHR11669:SF1	REPLICATION FACTOR C SUBUNIT 3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CAEEL|WormBase=WBGene00000065|UniProtKB=P0DM42	Actin-3	IDA	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	BOVIN|Ensembl=ENSBTAG00000011723|UniProtKB=E1BKL6	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	TAS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00238	Ras	CHICK|Ensembl=ENSGALG00000006885|UniProtKB=P08642	GTPase HRas	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P04375	5HT3 type receptor mediated signaling pathway	P04425	K+ channel	MOUSE|MGI=MGI=3521816|UniProtKB=Q3LS21	Potassium channel subfamily K member 9	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	IC	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	CANLF|Ensembl=ENSCAFG00000004399|UniProtKB=E2RIL8	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF23	FRIZZLED-4
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00056	VEGF signaling pathway	P01425	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	2837282	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DANRE|ZFIN=ZDB-GENE-030131-55|UniProtKB=Q6XNL8	Actin	IEP	11889139	PubMed	PTHR11937:SF263	ACTIN
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P06664	Gonadotropin-releasing hormone receptor pathway	P06769	Gbeta	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00025	Hedgehog signaling pathway	P00692	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00057	Wnt signaling pathway	P01451	Galpha	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	IDA	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00975	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	11847220	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000021900|UniProtKB=F1MFK1	Uncharacterized protein	ISS	10644715	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	CHICK|Ensembl=ENSGALG00000002447|UniProtKB=E1C7M7	Uncharacterized protein	ISS	1904011	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01167	Ets	HUMAN|HGNC=4071|UniProtKB=Q06546	GA-binding protein alpha chain	ISS	15298723	PubMed	PTHR11849:SF195	GA-BINDING PROTEIN ALPHA CHAIN
P02776	Serine glycine biosynthesis	P03160	Phosphoglycerate dehydrogenase	METJA|EnsemblGenome=MJ_1018|UniProtKB=Q58424	D-3-phosphoglycerate dehydrogenase	ISS			PTHR42938:SF9	FORMATE DEHYDROGENASE 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00796	Kainate receptor	PANTR|Ensembl=ENSPTRG00000018449|UniProtKB=H2QTG5	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00054	Toll receptor signaling pathway	P01352	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	IDA	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MACMU|Ensembl=ENSMMUG00000014601|UniProtKB=B8XIA5	Myc proto-oncogene protein	ISS	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CHICK|Ensembl=ENSGALG00000001172|UniProtKB=P19439	Probable glutamate receptor	IC	11319238	PubMed	PTHR18966:SF282	GLUTAMATE RECEPTOR-RELATED
P00018	EGF receptor signaling pathway	P00542	EGFR	MOUSE|MGI=MGI=104771|UniProtKB=Q61527	Receptor tyrosine-protein kinase erbB-4	ISS	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000000365|UniProtKB=F6R9F4	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	MOUSE|MGI=MGI=96567|UniProtKB=P50096	Inosine-5'-monophosphate dehydrogenase 1	ISS			PTHR11911:SF74	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 1
P00010	B cell activation	P00384	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IDA	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	BOVIN|Gene=ACVR1|UniProtKB=Q28041	Activin receptor type-1	TAS	9395284	PubMed	PTHR23255:SF69	ACTIVIN RECEPTOR TYPE-1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00632	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2746|UniProtKB=P31424	Metabotropic glutamate receptor 5	IDA			PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00029	Huntington disease	P00786	ARF	RAT|RGD=621326|UniProtKB=P61212	ADP-ribosylation factor-like protein 1	IPI	12932731	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	PANTR|Ensembl=ENSPTRG00000016156|UniProtKB=H2QPN4	C-X-C motif chemokine	ISS	9910486	gi	PTHR10179:SF38	PLATELET FACTOR 4 VARIANT
P00049	Parkinson disease	P01208	Hsp70	STRCO|EnsemblGenome=CAD55329|UniProtKB=Q05558	Chaperone protein DnaK	IDA	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	MOUSE|MGI=MGI=2442695|UniProtKB=Q8BH52	Cyclic AMP-responsive element-binding protein 3-like protein 2	ISS	608972	OMIM	PTHR22952:SF96	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9441|UniProtKB=P51817	cAMP-dependent protein kinase catalytic subunit PRKX	IC	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00644	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008422|UniProtKB=F6VUT7	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01076	CAT	CAEEL|WormBase=WBGene00000481|UniProtKB=P32756	Choline O-acetyltransferase	ISS	97225904	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P00048	PI3 kinase pathway	P01199	Galpha	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MONDO|Ensembl=ENSMODG00000020977|UniProtKB=F6S5B1	Uncharacterized protein (Fragment)	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	IDA	94313981	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	ISS	9199552	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	PHYIT|EnsemblGenome=PITG_06376|UniProtKB=D0N4Q3	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta, putative	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00025	Hedgehog signaling pathway	P00682	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	CAEBR|Gene=CBG06092|UniProtKB=A8X0X5	Protein CBR-LET-60	ISS	12024031	PubMed	PTHR24070:SF385	GTPASE HRAS
P00029	Huntington disease	P00780	Microtubule	PHYPA|Gene=PHYPADRAFT_223212|UniProtKB=Q6TYR5	Beta-tubulin 3	ISS	12932731	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	RCA	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IDA	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00006	Apoptosis signaling pathway	P00260	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01312	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00036	Interleukin signaling pathway	P00983	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	CAEEL|WormBase=WBGene00004769|UniProtKB=P52166	Presenilin sel-12	IDA	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00796	Kainate receptor	HUMAN|HGNC=4583|UniProtKB=Q16478	Glutamate receptor ionotropic, kainate 5	IDA	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00048	PI3 kinase pathway	P01188	Gbetagamma	SCLS1|EnsemblGenome=SS1G_03482|UniProtKB=A7EDU2	Guanine nucleotide-binding protein beta subunit	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	BOVIN|Ensembl=ENSBTAG00000037811|UniProtKB=P28291	C-C motif chemokine 2	ISS			PTHR12015:SF98	C-C MOTIF CHEMOKINE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00057	Wnt signaling pathway	P01435	SWI/SNF	CANLF|Ensembl=ENSCAFG00000012314|UniProtKB=E2RSH9	Uncharacterized protein	ISS	11532957	PubMed	PTHR12656:SF12	AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 1A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=99842|UniProtKB=Q02284	5-hydroxytryptamine receptor 1F	IDA	1608964	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00018	EGF receptor signaling pathway	P00558	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00210	eNOS	CANLF|Gene=NOS3|UniProtKB=Q9TUX8	Nitric oxide synthase, endothelial	ISS	10435050	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MACMU|Ensembl=ENSMMUG00000009341|UniProtKB=F6UA54	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	RAT|RGD=3139|UniProtKB=Q29RW1	Myosin-4	ISS	10938134	PubMed	PTHR13140:SF657	MYOSIN-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00012	Cadherin signaling pathway	P00475	Frizzled	DANRE|ZFIN=ZDB-GENE-990415-223|UniProtKB=Q6NV44	Frizzled homolog 7a	IDA	8717036	PubMed	PTHR11309:SF31	FRIZZLED-7
P05731	GABA-B receptor II signaling	P05754	Ggamma	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	IDA	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00029	Huntington disease	P00797	p53	ORNAN|Ensembl=ENSOANG00000013795|UniProtKB=F7DUR2	Uncharacterized protein (Fragment)	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00036	Interleukin signaling pathway	P00977	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P05915	Opioid proenkephalin pathway	P05995	proenkephalin	MACMU|Ensembl=ENSMMUG00000006775|UniProtKB=F7H3N8	Uncharacterized protein	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	CHICK|Ensembl=ENSGALG00000013760|UniProtKB=F1P1F9	Uncharacterized protein	ISS			PTHR10937:SF10	GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE  ISOMERIZING  2
P00029	Huntington disease	P00807	Actin	ENTHI|EnsemblGenome=EHI_107290|UniProtKB=B1N2P0	Actin	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00036	Interleukin signaling pathway	P00966	mTOR	RAT|RGD=68371|UniProtKB=P42346	Serine/threonine-protein kinase mTOR	IGI	14526383	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00017	DNA replication	P00533	Pol delta	DANRE|ZFIN=ZDB-GENE-030616-157|UniProtKB=B0R0V1	Uncharacterized protein	NAS	16501182	gi	PTHR10416:SF0	DNA POLYMERASE DELTA SUBUNIT 2
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	ARATH|TAIR=AT1G13890|UniProtKB=Q9LMG8	Putative SNAP25 homologous protein SNAP30	IC			PTHR19305:SF7	SNAP25 HOMOLOGOUS PROTEIN SNAP30-RELATED
P04393	Ras Pathway	P04556	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04396	Vitamin D metabolism and pathway	P04607	FDX	ARATH|TAIR=AT4G05450|UniProtKB=Q9M0V0	Adrenodoxin-like protein 1, mitochondrial	ISS			PTHR23426:SF25	FERREDOXIN 2
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	RCA	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00021	FGF signaling pathway	P00629	PP2A	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00756	Recoverin	MACMU|Ensembl=ENSMMUG00000018091|UniProtKB=F7EG53	Cancer-associated retinopathy protein	ISS	7608179	PubMed	PTHR23055:SF20	RECOVERIN
P00036	Interleukin signaling pathway	P00985	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	11256888	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00029	Huntington disease	P00779	TBP	METAC|EnsemblGenome=MA_4331|UniProtKB=Q8TI26	TATA-box-binding protein 1	IPI	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00045	Notch signaling pathway	P01114	Ntm	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00034	Integrin signalling pathway	P00910	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	8262390	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P02726	Aminobutyrate degradation	P02825	4-aminobutyrate aminotransferase	PSEAE|EnsemblGenome=PA0266|UniProtKB=Q9I6M4	5-aminovalerate aminotransferase DavT	ISS			PTHR43206:SF2	4-AMINOBUTYRATE AMINOTRANSFERASE GABT
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PRIPA|Gene=PPA23459|UniProtKB=H3FMF2	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00029	Huntington disease	P00796	Kainate receptor	PANTR|Ensembl=ENSPTRG00000011042|UniProtKB=H2QGF5	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MACMU|Ensembl=ENSMMUG00000001458|UniProtKB=F7BKH1	Uncharacterized protein	ISS	12963527	gi	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00018	EGF receptor signaling pathway	P00561	STAT	HUMAN|HGNC=11367|UniProtKB=P51692	Signal transducer and activator of transcription 5B	IGI	95236292	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	MOUSE|MGI=MGI=102891|UniProtKB=P51829	Adenylate cyclase type 7	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00021	FGF signaling pathway	P00629	PP2A	ANOGA|EnsemblGenome=AGAP003779|UniProtKB=Q7QFY4	Serine/threonine-protein phosphatase	ISS			PTHR11668:SF22	SERINE/THREONINE-PROTEIN PHOSPHATASE 4 CATALYTIC SUBUNIT
P04375	5HT3 type receptor mediated signaling pathway	P04421	5HT transporter	HUMAN|HGNC=11050|UniProtKB=P31645	Sodium-dependent serotonin transporter	ISS	14653308	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00634	MEKK1-5	RAT|RGD=1304625|UniProtKB=D3ZFL3	Mitogen-activated protein kinase kinase kinase 6 (Predicted)	ISS			PTHR11584:SF391	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 6
P00036	Interleukin signaling pathway	P00983	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02776	Serine glycine biosynthesis	P03160	Phosphoglycerate dehydrogenase	DROME|FlyBase=FBgn0032350|UniProtKB=Q9VKI8	CG6287	ISS			PTHR42938:SF5	D-3-PHOSPHOGLYCERATE DEHYDROGENASE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00005	Angiogenesis	P00200	Dsh	MONDO|Ensembl=ENSMODG00000006553|UniProtKB=F7BUW7	Uncharacterized protein	ISS	10409711	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	RAT|RGD=1305144|UniProtKB=D4AE24	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00034	Integrin signalling pathway	P00943	Talin	HUMAN|HGNC=11845|UniProtKB=Q9Y490	Talin-1	IPI	14702644	PubMed	PTHR19981:SF7	MESODERM DEVELOPMENT CANDIDATE 1-RELATED
P00060	Ubiquitin proteasome pathway	P01491	E2	XENTR|Xenbase=XB-GENE-943749|UniProtKB=F6W7A5	Uncharacterized protein	ISS			PTHR43902:SF2	UBIQUITIN-CONJUGATING ENZYME E2 N
P00057	Wnt signaling pathway	P01444	Wnt	MACMU|Ensembl=ENSMMUG00000017346|UniProtKB=F7H9B8	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	MOUSE|MGI=MGI=99685|UniProtKB=E9Q401	Ryanodine receptor 2	ISS	15858232	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00053	T cell activation	P01305	Calmodulin	NEMVE|Gene=v1g88970|UniProtKB=A7RPN8	Predicted protein (Fragment)	ISS			PTHR23050:SF245	AT16150P-RELATED
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=2652894|UniProtKB=Q80Y86	Mitogen-activated protein kinase 15	ISS	12787066	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00018	EGF receptor signaling pathway	P00547	PP2A	CHICK|Ensembl=ENSGALG00000010273|UniProtKB=P48463	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	NAS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00034	Integrin signalling pathway	P00951	Jnk	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00020	FAS signaling pathway	P00615	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	TAS	97102675	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	IDA	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00007	Axon guidance mediated by semaphorins	P00341	Rho	BOVIN|Ensembl=ENSBTAG00000004279|UniProtKB=P61585	Transforming protein RhoA	ISS	12169092	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00010	B cell activation	P00385	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	8649368	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00001	Adrenaline and noradrenaline biosynthesis	P00062	TH	RAT|RGD=3853|UniProtKB=P04177	Tyrosine 3-monooxygenase	ISS	191290	OMIM	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P02788	Xanthine and guanine salvage pathway	P03247	Xanthine phosphoribosyl transferase	TRYB2|Gene=Tb10.70.6540|UniProtKB=Q38C93	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00006	Apoptosis signaling pathway	P00323	Bcl-xS	RAT|RGD=1590919|UniProtKB=E9PU78	Protein Bcl2l1-ps1	ISS			PTHR11256:SF12	BCL-2-LIKE PROTEIN 1
P00034	Integrin signalling pathway	P00920	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00054	Toll receptor signaling pathway	P01358	ERK1	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00059	p53 pathway	P04630	PP2A	DANRE|ZFIN=ZDB-GENE-050417-441|UniProtKB=Q567Y8	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00046	Oxidative stress response	P01126	ATF2	CHICK|Ensembl=ENSGALG00000009287|UniProtKB=O93602	Cyclic AMP-dependent transcription factor ATF-2	TAS	10664585	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g242065|UniProtKB=A7S0V7	Predicted protein	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05730	Endogenous cannabinoid signaling	P05746	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00796	Kainate receptor	MACMU|Ensembl=ENSMMUG00000022347|UniProtKB=F6ZCH5	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05913	Enkephalin release	P05974	G-Protein (i)	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	BOVIN|Ensembl=ENSBTAG00000004216|UniProtKB=F1MSX4	Uncharacterized protein	ISS	8649450	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DANRE|ZFIN=ZDB-GENE-040718-134|UniProtKB=Q6DH55	Guanine nucleotide binding protein (G protein), beta polypeptide 3, like	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00018	EGF receptor signaling pathway	P00539	14-3-3	ORYSJ|EnsemblGenome=OS08G0480800|UniProtKB=Q84J55	14-3-3-like protein GF14-A	ISS	20493542	PubMed	PTHR18860:SF26	14-3-3 FAMILY PROTEIN-RELATED
P05731	GABA-B receptor II signaling	P05755	Gbeta	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	MOUSE|MGI=MGI=88399|UniProtKB=P32211	Muscarinic acetylcholine receptor M4	ISS	11166329	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00005	Angiogenesis	P00227	PLA2	RAT|RGD=67366|UniProtKB=P50393	Cytosolic phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	DROME|FlyBase=FBgn0011300|UniProtKB=A1Z7L8	Receptor protein serine/threonine kinase	IDA			PTHR23255:SF71	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00017	DNA replication	P00535	5' to 3' Exoribonulcease	PANTR|Ensembl=ENSPTRG00000013308|UniProtKB=H2QK18	5'-3' exoribonuclease 2	ISS	99339991	PubMed	PTHR12341:SF41	5'-3' EXORIBONUCLEASE 2
P00048	PI3 kinase pathway	P01196	PDK1	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	IGI	11256888	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	HUMAN|HGNC=10003|UniProtKB=P49802	Regulator of G-protein signaling 7	IDA	8756726	PubMed	PTHR10845:SF26	REGULATOR OF G-PROTEIN SIGNALING 7
P00021	FGF signaling pathway	P00629	PP2A	PHYPA|Gene=PHYPADRAFT_109960|UniProtKB=A9SI18	Serine/threonine-protein phosphatase	ISS			PTHR11668:SF318	SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-4 CATALYTIC SUBUNIT
P00010	B cell activation	P00398	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00019	Endothelin signaling pathway	P00582	COX-2	CANLF|Ensembl=ENSCAFG00000013762|UniProtKB=Q8SPQ9	Cyclooxygenase 2	IGI	12163371	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	20010089	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04397	p53 pathway by glucose deprivation	P04641	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00021	FGF signaling pathway	P00641	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	8920915	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	PANTR|Ensembl=ENSPTRG00000029076|UniProtKB=H2R686	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF63	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	LEIMA|EnsemblGenome=LmjF.36.6470|UniProtKB=Q4Q0B0	Mitogen-activated protein kinase	ISS			PTHR24055:SF178	SUBFAMILY NOT NAMED
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	ORNAN|Ensembl=ENSOANG00000003489|UniProtKB=F7FSE3	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	HUMAN|HGNC=18855|UniProtKB=Q68CJ9	Cyclic AMP-responsive element-binding protein 3-like protein 3	ISS	608972	OMIM	PTHR22952:SF98	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 3
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ORYSJ|EnsemblGenome=OS12G0163700|UniProtKB=Q0IPW3	Os12g0163700 protein	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01457	GBeta	SCLS1|EnsemblGenome=SS1G_03482|UniProtKB=A7EDU2	Guanine nucleotide-binding protein beta subunit	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00029	Huntington disease	P00786	ARF	MACMU|Ensembl=ENSMMUG00000021421|UniProtKB=F7EF01	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF234	ADP-RIBOSYLATION FACTOR 1
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00054	Toll receptor signaling pathway	P01358	ERK1	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IPI	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	RAT|RGD=619965|UniProtKB=P26769	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IC	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02784	Tyrosine biosynthesis	P03213	Aromatic amino acid aminotransferase	CHLTR|EnsemblGenome=CT_637|UniProtKB=O84642	Aromatic AA Aminotransferase	ISS			PTHR11879:SF10	ASPARTATE AMINOTRANSFERASE
P06959	CCKR signaling map	P07085	RAF1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	RCA	15153424	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00060	Ubiquitin proteasome pathway	P01490	E3	HUMAN|HGNC=16809|UniProtKB=Q9HAU4	E3 ubiquitin-protein ligase SMURF2	ISS	11252892	PubMed	PTHR11254:SF300	E3 UBIQUITIN-PROTEIN LIGASE SMURF2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04393	Ras Pathway	P04552	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00053	T cell activation	P01299	TCR Beta	PANTR|Ensembl=ENSPTRG00000039309|UniProtKB=H2RGZ2	Uncharacterized protein	ISS			PTHR23268:SF20	T-CELL RECEPTOR BETA CHAIN V REGION CTL-L17
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	HUMAN|HGNC=173|UniProtKB=P27037	Activin receptor type-2A	TAS	11252892	PubMed	PTHR23255:SF64	ACTIVIN RECEPTOR TYPE-2A
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	BOVIN|Ensembl=ENSBTAG00000031061|UniProtKB=Q32P78	DNA-directed RNA polymerases I, II, and III subunit RPABC5	ISS			PTHR23431:SF3	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05754	Ggamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	10891487	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00053	T cell activation	P01311	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IDA	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	EMENI|EnsemblGenome=CADANIAG00002670|UniProtKB=Q5BH99	G-protein beta subunit [Source:UniProtKB/TrEMBLAcc:O74214]	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00053	T cell activation	P01295	vav	MACMU|Ensembl=ENSMMUG00000019714|UniProtKB=F7H0I2	Uncharacterized protein	ISS	14623913	PubMed	PTHR22826:SF97	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3
P00049	Parkinson disease	P01238	14-3-3	SCHMA|EnsemblGenome=Smp_034840|UniProtKB=G4V8A9	14-3-3 epsilon	IDA	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00021	FGF signaling pathway	P00627	ERK1-2	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00931	Integrin beta	MACMU|Ensembl=ENSMMUG00000002873|UniProtKB=F7HFS4	Uncharacterized protein	ISS	3487386	PubMed	PTHR10082:SF3	INTEGRIN BETA-LIKE PROTEIN 1
P00057	Wnt signaling pathway	P01471	alpha-catenin	CHICK|Ensembl=ENSGALG00000002447|UniProtKB=E1C7M7	Uncharacterized protein	ISS	9362521	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	ORYSJ|EnsemblGenome=OS06G0168600|UniProtKB=Q5VRF5	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00029	Huntington disease	P00805	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00559	MEK1-2	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IGI	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00021	FGF signaling pathway	P00640	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04657	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT2G43790|UniProtKB=Q39026	Mitogen-activated protein kinase 6	ISS	9836510	gi	PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P00047	PDGF signaling pathway	P01167	Ets	CAEEL|WormBase=WBGene00020368|UniProtKB=Q22355	Axon STeering defect	ISS	15298723	PubMed	PTHR11849:SF269	AXON STEERING DEFECT
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00586	Gq	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00059	p53 pathway	P04611	P300	MACMU|Ensembl=ENSMMUG00000000893|UniProtKB=F6T7D0	Histone acetyltransferase p300	ISS	10664585	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00019	Endothelin signaling pathway	P00591	PLCbeta	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00049	Parkinson disease	P01227	20S proteasome	RAT|RGD=61844|UniProtKB=P18422	Proteasome subunit alpha type-3	TAS	12859888	PubMed	PTHR11599:SF10	PROTEASOME SUBUNIT ALPHA TYPE-3
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00037	Ionotropic glutamate receptor pathway	P01018	Glu1	CAEEL|WormBase=WBGene00001612|UniProtKB=P34299	Glutamate receptor 1	ISS	8804111	PubMed	PTHR18966:SF297	GLUTAMATE RECEPTOR 1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS	12052864	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	DROME|FlyBase=FBgn0005278|UniProtKB=P40320	S-adenosylmethionine synthase	ISS			PTHR11964:SF1	S-ADENOSYLMETHIONINE SYNTHASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00054	Toll receptor signaling pathway	P01376	Uev1A	XENTR|Xenbase=XB-GENE-950453|UniProtKB=F7EKS7	Uncharacterized protein	ISS			PTHR43915:SF2	UBIQUITIN-CONJUGATING ENZYME E2 VARIANT 1
P06587	Nicotine pharmacodynamics pathway	P06601	FLNA	HUMAN|HGNC=3754|UniProtKB=P21333	Filamin-A	IDA	11911837	PubMed	PTHR43998:SF6	FILAMIN-A
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00054	Toll receptor signaling pathway	P01358	ERK1	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00057	Wnt signaling pathway	P01456	beta-arrestin	HUMAN|HGNC=711|UniProtKB=P49407	Beta-arrestin-1	IDA	4757780	gi	PTHR11792:SF22	BETA-ARRESTIN-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04455	beta-endorphin	MONDO|Ensembl=ENSMODG00000015853|UniProtKB=Q95J84	Proopiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	ARATH|TAIR=AT1G79470|UniProtKB=P47996	Inosine-5'-monophosphate dehydrogenase 1	ISS			PTHR11911:SF111	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE
P00049	Parkinson disease	P01230	Src kinase	XENTR|Xenbase=XB-GENE-6053489|UniProtKB=F6S8L5	Tyrosine-protein kinase	ISS	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00047	PDGF signaling pathway	P01149	MNK1/2	MOUSE|MGI=MGI=894279|UniProtKB=Q8CDB0	MAP kinase-interacting serine/threonine-protein kinase 2	ISS	9155017	PubMed	PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P00047	PDGF signaling pathway	P01160	IP3 receptor	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CAEEL|WormBase=WBGene00001612|UniProtKB=P34299	Glutamate receptor 1	IC	12941441	PubMed	PTHR18966:SF297	GLUTAMATE RECEPTOR 1
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	SYNY3|EnsemblGenome=BAA17124|UniProtKB=P77962	Serine hydroxymethyltransferase	ISS			PTHR11680:SF21	SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC
P00053	T cell activation	P01332	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	RAT|RGD=628837|UniProtKB=P60711	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00036	Interleukin signaling pathway	P00965	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IC	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12805548	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00012	Cadherin signaling pathway	P00464	Fyn	TAKRU|Ensembl=ENSTRUG00000014739|UniProtKB=H2UL58	Tyrosine-protein kinase	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P05913	Enkephalin release	P05972	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	14526383	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00020	FAS signaling pathway	P00615	JNK	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	RAT|RGD=621528|UniProtKB=Q9JII9	C-X-C chemokine receptor type 3	ISS	6753458	gi	PTHR10489:SF671	C-X-C CHEMOKINE RECEPTOR TYPE 3
P00006	Apoptosis signaling pathway	P00260	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04626	GADD45	MOUSE|MGI=MGI=107799|UniProtKB=P48316	Growth arrest and DNA damage-inducible protein GADD45 alpha	IGI	10097101	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g210933|UniProtKB=A7SEA7	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IDA	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00034	Integrin signalling pathway	P00948	Rho	BOVIN|Ensembl=ENSBTAG00000004279|UniProtKB=P61585	Transforming protein RhoA	ISS	12039949	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00036	Interleukin signaling pathway	P00993	p21CIP1	MACMU|Ensembl=ENSMMUG00000003210|UniProtKB=F7EEK4	Cyclin-dependent kinase inhibitor 1	ISS			PTHR10265:SF16	CYCLIN-DEPENDENT KINASE INHIBITOR 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01413	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00640	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	TAS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05734	Synaptic vesicle trafficking	P05779	Synaptobrevin	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04376	5HT4 type receptor mediated signaling pathway	P04426	K+ channel	PANTR|Ensembl=ENSPTRG00000020614|UniProtKB=H2QWR7	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00005	Angiogenesis	P00245	Rac	PANTR|Ensembl=ENSPTRG00000014488|UniProtKB=H2QLV6	Proline rich 5 (Renal)	ISS			PTHR32428:SF4	PROLINE-RICH PROTEIN 5
P00005	Angiogenesis	P00231	HSP27	ANOGA|EnsemblGenome=AGAP005548|UniProtKB=Q7Q723	AGAP005548-PA	ISS			PTHR11527:SF252	HEAT SHOCK PROTEIN BETA-11
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00005	Angiogenesis	P00254	GTPase	XENTR|Xenbase=XB-GENE-941426|UniProtKB=Q28HZ4	Novel Rho protein	ISS	11360179	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	TAS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00018	EGF receptor signaling pathway	P00545	JNK1-3	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000008867|UniProtKB=H2QCF3	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	PANTR|Ensembl=ENSPTRG00000016003|UniProtKB=H2QPD3	Uncharacterized protein	ISS			PTHR18945:SF489	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-9
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	DANRE|ZFIN=ZDB-GENE-050522-384|UniProtKB=F1QKY8	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01164	PDK1/2	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	ISS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00038	JAK/STAT signaling pathway	P01027	STAT	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	12191995	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	IC	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01145	c-fos	XENTR|Xenbase=XB-GENE-866811|UniProtKB=F7EI91	Uncharacterized protein (Fragment)	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	MACMU|Ensembl=ENSMMUG00000022578|UniProtKB=F7BKQ5	Uncharacterized protein	ISS	11430913	PubMed	PTHR23122:SF40	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P05915	Opioid proenkephalin pathway	P05994	G-protein	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05918	p38 MAPK pathway	P06030	IL-1R	MOUSE|MGI=MGI=96545|UniProtKB=P13504	Interleukin-1 receptor type 1	RCA			PTHR11890:SF26	INTERLEUKIN-1 RECEPTOR TYPE 1
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	IDA			PTHR13808:SF5	CREB-BINDING PROTEIN
P00057	Wnt signaling pathway	P01428	Frizzled	MACMU|Ensembl=ENSMMUG00000013215|UniProtKB=F6X7X4	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF31	FRIZZLED-7
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00053	T cell activation	P01330	IKK	RAT|RGD=621375|UniProtKB=Q9QY78	Inhibitor of nuclear factor kappa-B kinase subunit beta	IGI	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	TAS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05730	Endogenous cannabinoid signaling	P05746	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05915	Opioid proenkephalin pathway	P05990	K+ channel	PANTR|Ensembl=ENSPTRG00000020614|UniProtKB=H2QWR7	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00029	Huntington disease	P00796	Kainate receptor	CHICK|Ensembl=ENSGALG00000015835|UniProtKB=F1NZT2	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00034	Integrin signalling pathway	P00931	Integrin beta	MOUSE|MGI=MGI=2443439|UniProtKB=Q8VDV0	Integrin beta-like protein 1	IDA	3487386	PubMed	PTHR10082:SF3	INTEGRIN BETA-LIKE PROTEIN 1
P00029	Huntington disease	P00811	Arp2/3 complex	SCHPO|PomBase=SPBC14C8.06|UniProtKB=P78774	Actin-related protein 2/3 complex subunit 1	TAS	12963527	gi	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P00010	B cell activation	P00398	IP3R	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	IGI	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MOUSE|MGI=MGI=2664387|UniProtKB=Q8K3F2	Matrix metalloproteinase-21	TAS	12834808	PubMed	PTHR10201:SF147	MATRIX METALLOPROTEINASE-21
P00010	B cell activation	P00380	fos	CANLF|Ensembl=ENSCAFG00000017040|UniProtKB=E2QYK5	Uncharacterized protein	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	RAT|RGD=620196|UniProtKB=P23097	Collagenase 3 (Fragment)	TAS	1383028	PubMed	PTHR10201:SF165	COLLAGENASE 3
P00029	Huntington disease	P00807	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g234494|UniProtKB=A7RU31	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02729	Ascorbate degradation	P02852	L-xylulose-5-phosphate-3-epimerase	ARATH|TAIR=AT3G01850|UniProtKB=Q94K13	Ribulose-phosphate 3-epimerase	ISS			PTHR11749:SF3	RIBULOSE-PHOSPHATE 3-EPIMERASE
P00021	FGF signaling pathway	P00642	MEK1-2	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	CANLF|Ensembl=ENSCAFG00000007755|UniProtKB=E2R431	S-adenosylmethionine synthase	ISS			PTHR11964:SF12	S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2
P00029	Huntington disease	P00786	ARF	MOUSE|MGI=MGI=99437|UniProtKB=P61213	ADP-ribosylation factor-like protein 4A	IPI	12932731	PubMed	PTHR11711:SF139	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 4A
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00006	Apoptosis signaling pathway	P00269	MAPK	CHLRE|EnsemblGenome=CHLREDRAFT_193901|UniProtKB=Q9FXT7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00047	PDGF signaling pathway	P01168	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	ISS	10799299	PubMed	PTHR10048:SF14	PI-3 KINASE
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	YEAST|SGD=S000003631|UniProtKB=Q01389	Serine/threonine-protein kinase BCK1/SLK1/SSP31	ISS			PTHR24361:SF611	SERINE/THREONINE-PROTEIN KINASE BCK1/SLK1/SSP31
P00021	FGF signaling pathway	P00629	PP2A	ANOGA|EnsemblGenome=AGAP010172|UniProtKB=Q7PD38	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01435	SWI/SNF	BOVIN|Ensembl=ENSBTAG00000021062|UniProtKB=E1BJD1	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2	ISS	11532957	PubMed	PTHR13844:SF2	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D MEMBER 2
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CANLF|Ensembl=ENSCAFG00000019387|UniProtKB=F1Q1E2	Uncharacterized protein	ISS	10485843	PubMed	PTHR10005:SF15	SKI ONCOGENE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	HUMAN|HGNC=27309|UniProtKB=Q86XF0	Dihydrofolate reductase, mitochondrial	ISS			PTHR22778:SF26	DIHYDROFOLATE REDUCTASE, MITOCHONDRIAL
P00019	Endothelin signaling pathway	P00585	ECE1-3	DROME|FlyBase=FBgn0031081|UniProtKB=Q9W5Y0	FI17316p1	ISS			PTHR11733:SF160	FI17316P1-RELATED
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	TAS	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02920	dCTP deaminase	STRCO|Gene=CAD30959|UniProtKB=Q9ADJ9	Putative deaminase	ISS			PTHR44192:SF2	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=8153|UniProtKB=P41143	Delta-type opioid receptor	IDA	12093103	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00038	JAK/STAT signaling pathway	P01027	STAT	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00047	PDGF signaling pathway	P01163	c-Jun	XENTR|Xenbase=XB-GENE-482228|UniProtKB=F6RYL1	Uncharacterized protein	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	PANTR|Ensembl=ENSPTRG00000022245|UniProtKB=H2QZ29	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P05915	Opioid proenkephalin pathway	P05994	G-protein	MACMU|Ensembl=ENSMMUG00000010392|UniProtKB=F7ASR8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01081	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000018655|UniProtKB=F7A5C9	Uncharacterized protein	ISS	21601730	PubMed	PTHR10166:SF6	VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	TAS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MONDO|Ensembl=ENSMODG00000012401|UniProtKB=F6PMQ6	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	BOVIN|Ensembl=ENSBTAG00000007988|UniProtKB=F1MNQ8	Uncharacterized protein	ISS			PTHR19957:SF36	SYNTAXIN-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DROME|FlyBase=FBgn0000043|UniProtKB=P02572	Actin-42A	ISS	11889126	PubMed	PTHR11937:SF369	ACTIN-42A
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	RAT|RGD=621060|UniProtKB=O88777	Presenilin-2	IDA	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P05912	Dopamine receptor mediated signaling pathway	P05961	DOPA decarb.	ARATH|TAIR=AT4G28680|UniProtKB=Q9M0G4	Probable tyrosine decarboxylase 2	ISS			PTHR11999:SF70	MIP05841P
P00048	PI3 kinase pathway	P01192	p110	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	IGI	10799299	PubMed	PTHR10048:SF14	PI-3 KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	IC	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P05918	p38 MAPK pathway	P06031	p38alpha	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00025	Hedgehog signaling pathway	P00691	CBP	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04393	Ras Pathway	P04557	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IDA	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_114535|UniProtKB=C3ZHN2	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00053	T cell activation	P01309	fos	BOVIN|Ensembl=ENSBTAG00000004322|UniProtKB=O77628	Proto-oncogene c-Fos	TAS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00029	Huntington disease	P00810	GAPDH	TRIVA|Gene=TVAG_347410|UniProtKB=A2FNQ3	Glyceraldehyde-3-phosphate dehydrogenase	IPI			PTHR43148:SF2	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE C-RELATED
P00006	Apoptosis signaling pathway	P00274	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00036	Interleukin signaling pathway	P00965	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IC	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00628	JNK1-3	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	RCA	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00010	B cell activation	P00386	Calcineurin	BOVIN|Ensembl=ENSBTAG00000016005|UniProtKB=P48452	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	IDA	12091710	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00590	IP3 R	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	IGI	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00036	Interleukin signaling pathway	P00973	PKB	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00633	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	IDA	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	IC	1319556	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	RCA	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00019	Endothelin signaling pathway	P00584	Gs	SCHMA|EnsemblGenome=Smp_059340|UniProtKB=C4QDC7	Guanine nucleotide-binding protein G(S) subunit alpha (Adenylate cyclase-stimulating G alpha protein),putative	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00005	Angiogenesis	P00189	Fzd	PANTR|Ensembl=ENSPTRG00000012855|UniProtKB=H2QJA9	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF126	FRIZZLED-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MACMU|Ensembl=ENSMMUG00000019351|UniProtKB=Q2YEG0	C-X-C chemokine receptor type 1	ISS	6753456	gi	PTHR10489:SF916	C-X-C CHEMOKINE RECEPTOR TYPE 1
P04395	Vasopressin synthesis	P04597	Signal Peptide	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00010	B cell activation	P00371	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CAEEL|WormBase=WBGene00004036|UniProtKB=G5EFI8	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00049	Parkinson disease	P01242	Casein kinase I	ARATH|TAIR=AT4G28540|UniProtKB=Q8LPJ1	Casein kinase 1-like protein 6	IDA	10617630	PubMed	PTHR11909:SF114	ADK1-RELATED
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00948	Rho	MONDO|Ensembl=ENSMODG00000012981|UniProtKB=F7CS91	Uncharacterized protein	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00012	Cadherin signaling pathway	P00470	F-actin	TRIVA|Gene=TVAG_054030|UniProtKB=A2G1K5	Actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00046	Oxidative stress response	P01131	MKP5	ORYSJ|EnsemblGenome=OS01G0390900|UniProtKB=Q5VNG7	Os01g0390900 protein	ISS			PTHR10159:SF402	DUAL SPECIFICITY PROTEIN PHOSPHATASE 19
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	TAKRU|Ensembl=ENSTRUG00000006307|UniProtKB=H2SSM1	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05730	Endogenous cannabinoid signaling	P05748	mGluR	CANLF|Ensembl=ENSCAFG00000004381|UniProtKB=J9JH96	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00056	VEGF signaling pathway	P01413	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P00049	Parkinson disease	P01212	p38 MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00053	T cell activation	P01322	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	CANLF|Ensembl=ENSCAFG00000001791|UniProtKB=J9NS92	Uncharacterized protein	ISS			PTHR11699:SF140	RETINAL DEHYDROGENASE 1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	RCA	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MOUSE|MGI=MGI=107861|UniProtKB=Q7TMM9	Tubulin beta-2A chain	ISS	9454836	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	IC	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00034	Integrin signalling pathway	P00950	Paxillin	HUMAN|HGNC=9718|UniProtKB=P49023	Paxillin	ISS	9182576	PubMed	PTHR24216:SF11	PAXILLIN
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00010	B cell activation	P00391	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	RAT|RGD=621515|UniProtKB=P61954	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	ISS	2122451	PubMed	PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P00018	EGF receptor signaling pathway	P00562	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00053	T cell activation	P01327	Gads	PANTR|Ensembl=ENSPTRG00000014404|UniProtKB=H2QLR1	Uncharacterized protein	ISS	51702266	gi	PTHR24418:SF299	GRB2-RELATED ADAPTER PROTEIN 2
P00052	TGF-beta signaling pathway	P01286	TGFbeta	CHICK|Gene=INHBA|UniProtKB=P27092	Inhibin beta A chain	TAS	11451570	PubMed	PTHR11848:SF133	INHIBIN BETA A CHAIN
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	XENTR|Xenbase=XB-GENE-481916|UniProtKB=F6YF14	Presenilin	ISS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	TAS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8681|UniProtKB=Q9UN67	Protocadherin beta-10	IDA	8120095	PubMed	PTHR24028:SF54	PROTOCADHERIN BETA-10
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01300	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	MACMU|Ensembl=ENSMMUG00000012033|UniProtKB=F7GWI2	Serine/threonine-protein kinase PAK 2	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	IC	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00587	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04570	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	MACMU|Gene=CHRM1|UniProtKB=P56489	Muscarinic acetylcholine receptor M1	ISS	11166329	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	MOUSE|MGI=MGI=2151136|UniProtKB=Q9JI18	Low-density lipoprotein receptor-related protein 1B	IDA	11907044	PubMed	PTHR44025:SF7	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B
P00021	FGF signaling pathway	P00627	ERK1-2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01432	Beta-Catenin	ORNAN|Ensembl=ENSOANG00000006811|UniProtKB=F6WBD5	Uncharacterized protein	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00036	Interleukin signaling pathway	P00965	ERK	CANLF|Ensembl=ENSCAFG00000018202|UniProtKB=E2RPJ2	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P02721	ATP synthesis	P02794	F1 beta	MOUSE|MGI=MGI=107801|UniProtKB=P56480	ATP synthase subunit beta, mitochondrial	ISS	2896550	PubMed	PTHR15184:SF44	ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	IC	91072385	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	CHICK|Ensembl=ENSGALG00000007871|UniProtKB=F1NL65	Uncharacterized protein	IC	94365697	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_115566|UniProtKB=C3XYC8	Putative uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	DROME|FlyBase=FBgn0019947|UniProtKB=O02194	Presenilin homolog	IDA	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00034	Integrin signalling pathway	P00934	VASP	MOUSE|MGI=MGI=109268|UniProtKB=P70460	Vasodilator-stimulated phosphoprotein	IPI	8836115	PubMed	PTHR11202:SF12	VASODILATOR-STIMULATED PHOSPHOPROTEIN
P00010	B cell activation	P00391	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00006	Apoptosis signaling pathway	P00302	ATF	MONDO|Ensembl=ENSMODG00000009514|UniProtKB=F7EVK3	Uncharacterized protein	ISS	7875593	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05918	p38 MAPK pathway	P06040	MSK1	PANTR|Ensembl=ENSPTRG00000006631|UniProtKB=H2Q8S3	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF115	RIBOSOMAL PROTEIN S6 KINASE ALPHA-5
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	ORNAN|Ensembl=ENSOANG00000006877|UniProtKB=F7CQF2	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00005	Angiogenesis	P00223	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00046	Oxidative stress response	P01129	JNK1/2	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000023202|UniProtKB=F7EU36	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00045	Notch signaling pathway	P01100	CoA	SCHPO|PomBase=SPAC1952.05|UniProtKB=Q9UUK2	Histone acetyltransferase gcn5	TAS	11112321	PubMed	PTHR22880:SF137	NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF
P00047	PDGF signaling pathway	P01161	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00049	Parkinson disease	P01227	20S proteasome	CIOIN|Ensembl=ENSCING00000019274|UniProtKB=H2XVD5	Proteasome subunit beta type	TAS	12859888	PubMed	PTHR11599:SF44	AT05866P-RELATED
P02761	Pantothenate biosynthesis	P03067	3-methyl-2-oxobutanoate hydroxymethyltransferase	ARATH|TAIR=AT2G46110|UniProtKB=O82357	3-methyl-2-oxobutanoate hydroxymethyltransferase 1, mitochondrial	ISS			PTHR20881:SF0	3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE
P00018	EGF receptor signaling pathway	P00560	Raf-1	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS			PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P04373	5HT1 type receptor mediated signaling pathway	P04409	5HT transporter	MOUSE|MGI=MGI=96285|UniProtKB=Q60857	Sodium-dependent serotonin transporter	IEA	14653308	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P00029	Huntington disease	P00786	ARF	XENTR|Xenbase=XB-GENE-484079|UniProtKB=Q5BJ34	ADP-ribosylation factor 4	ISS	12932731	PubMed	PTHR11711:SF110	ADP-RIBOSYLATION FACTOR 4
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	MOUSE|MGI=MGI=95814|UniProtKB=Q60934	Glutamate receptor ionotropic, kainate 1	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	STRCO|Gene=CAD55360|UniProtKB=Q8CJQ9	Putative aldehyde dehydrogenase	IC	14724059	PubMed	PTHR11699:SF109	GAMMA-AMINOBUTYRALDEHYDE DEHYDROGENASE
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT1G01560|UniProtKB=Q9LMM5	Mitogen-activated protein kinase 11	IDA	12787066	PubMed	PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00018	EGF receptor signaling pathway	P00561	STAT	MOUSE|MGI=MGI=103034|UniProtKB=P52633	Signal transducer and transcription activator 6	IGI	12039028	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00049	Parkinson disease	P01238	14-3-3	CHICK|Gene_ORFName=RCJMB04_1e8|UniProtKB=Q5ZMT0	14-3-3 protein epsilon	ISS	98119747	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00270	Bcl-2	MACMU|Ensembl=ENSMMUG00000006577|UniProtKB=F7HPT9	Uncharacterized protein	ISS	11323415	PubMed	PTHR11256:SF11	APOPTOSIS REGULATOR BCL-2
P04398	p53 pathway feedback loops 2	P04661	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01070	K+ channel	BOVIN|Ensembl=ENSBTAG00000003030|UniProtKB=F1MCH6	Uncharacterized protein	ISS	12165472	PubMed	PTHR11537:SF6	POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 2
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IC	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04397	p53 pathway by glucose deprivation	P04641	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	DANRE|ZFIN=ZDB-GENE-041026-4|UniProtKB=F1QDH9	Uncharacterized protein	ISS	22028976	PubMed	PTHR13140:SF707	SUBFAMILY NOT NAMED
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=2136754|UniProtKB=Q91VD8	MCG141290	IDA	8120095	PubMed	PTHR24028:SF71	PROTOCADHERIN BETA-16
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	TAS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	P01428	Frizzled	DANRE|ZFIN=ZDB-GENE-000906-4|UniProtKB=B0S5E7	Frizzled homolog 9	IDA	11212302	PubMed	PTHR11309:SF79	FRIZZLED-9
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01443	Phospholipase C	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02738	De novo purine biosynthesis	P02902	ADP reductase	SYNY3|Gene=BAA18852|UniProtKB=P74732	Ribonucleoside-diphosphate reductase subunit beta	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P02751	Lysine biosynthesis	P03013	Aspartate semialdehyde dehydrogenase	ARATH|TAIR=AT1G14810|UniProtKB=Q8VYI4	Aspartate semialdehyde dehydrogenase	ISS			PTHR10174:SF2	ASPARTATE-SEMIALDEHYDE DEHYDROGENASE
P00009	Axon guidance mediated by netrin	P00360	DCC/UNC-40	MONDO|Ensembl=ENSMODG00000011028|UniProtKB=F7F4D5	Uncharacterized protein	ISS	12810718	PubMed	PTHR44146:SF3	NETRIN RECEPTOR DCC
P00029	Huntington disease	P00780	Microtubule	PANTR|Ensembl=ENSPTRG00000027750|UniProtKB=H2QS82	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=109168|UniProtKB=F2Z4A3	Protein Fat1	IDA	8120095	PubMed	PTHR24026:SF42	PROTOCADHERIN FAT 1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00029	Huntington disease	P00790	beta-Tubulin	CAEBR|Gene=CBG20196|UniProtKB=A8XX81	Protein CBR-TBB-2	ISS	12932731	PubMed	PTHR11588:SF84	TUBULIN BETA-2 CHAIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	RAT|RGD=620351|UniProtKB=P18265	Glycogen synthase kinase-3 alpha	ISS	21361340	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	CANLF|Ensembl=ENSCAFG00000004956|UniProtKB=E2REH3	Uncharacterized protein	ISS	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00034	Integrin signalling pathway	P00925	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00539	14-3-3	RAT|RGD=3978|UniProtKB=P68511	14-3-3 protein eta	ISS	14593000	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00034	Integrin signalling pathway	P00946	Abl	MOUSE|MGI=MGI=87859|UniProtKB=P00520	Tyrosine-protein kinase ABL1	IDA	8986783	PubMed	PTHR24418:SF88	TYROSINE-PROTEIN KINASE ABL1
P00046	Oxidative stress response	P01128	MEF-2	ORNAN|Ensembl=ENSOANG00000000143|UniProtKB=F6VD47	Uncharacterized protein	ISS	11274345	PubMed	PTHR11945:SF145	MYOCYTE-SPECIFIC ENHANCER FACTOR 2A
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	RAT|RGD=1309115|UniProtKB=Q5PQJ6	Pyrroline-5-carboxylate reductase 3	ISS			PTHR11645:SF22	PYRROLINE-5-CARBOXYLATE REDUCTASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00057	Wnt signaling pathway	P01444	Wnt	MONDO|Ensembl=ENSMODG00000013810|UniProtKB=F6SXE3	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P02754	Methylcitrate cycle	P03028	Aconitase	ARATH|TAIR=AT2G05710|UniProtKB=Q9SIB9	Aconitate hydratase 2, mitochondrial	ISS			PTHR11670:SF50	ACONITATE HYDRATASE 2, MITOCHONDRIAL
P00005	Angiogenesis	P00222	VEGFR-2	HUMAN|HGNC=6307|UniProtKB=P35968	Vascular endothelial growth factor receptor 2	IDA	11824379	PubMed	PTHR24416:SF45	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	BOVIN|Ensembl=ENSBTAG00000008059|UniProtKB=P41984	Muscarinic acetylcholine receptor M3	TAS	8100450	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	PANTR|Ensembl=ENSPTRG00000022397|UniProtKB=H2QZ94	Uncharacterized protein	ISS			PTHR13058:SF20	THREE PRIME REPAIR EXONUCLEASE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	TRYB2|Gene=Tb10.70.0830|UniProtKB=Q38B01	Clathrin heavy chain	ISS	9388255	PubMed	PTHR10292:SF1	CLATHRIN HEAVY CHAIN
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P06664	Gonadotropin-releasing hormone receptor pathway	P06705	PLCbeta	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	RCA	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	MACMU|Gene=HTR2A|UniProtKB=P50128	5-hydroxytryptamine receptor 2A	ISS	12441358	PubMed	PTHR24247:SF30	5-HYDROXYTRYPTAMINE RECEPTOR 2A
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	RAT|RGD=1359694|UniProtKB=P62836	Ras-related protein Rap-1A	ISS	8576107	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00015	Circadian clock system	P00502	Casein kinase I	RAT|RGD=71031|UniProtKB=Q06486	Casein kinase I isoform delta	ISS	10617630	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000010521|UniProtKB=F7DQK7	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CANLF|Ensembl=ENSCAFG00000015815|UniProtKB=F1Q4F5	Adenylosuccinate synthetase isozyme 2	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00048	PI3 kinase pathway	P01179	PKB	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05917	Opioid proopiomelanocortin pathway	P06011	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	SCHPO|PomBase=SPBC56F2.09c|UniProtKB=O60060	Carbamoyl-phosphate synthase arginine-specific small chain	ISS			PTHR11405:SF4	CARBAMOYL-PHOSPHATE SYNTHASE ARGININE-SPECIFIC SMALL CHAIN
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00053	T cell activation	P01306	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00790	beta-Tubulin	DANRE|ZFIN=ZDB-GENE-031110-4|UniProtKB=Q6NW90	Tubulin, beta 5	ISS	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CANLF|Ensembl=ENSCAFG00000013148|UniProtKB=Q5R1P3	Glutamate receptor ionotropic, NMDA 2B	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MOUSE|MGI=MGI=95823|UniProtKB=Q03391	Glutamate receptor ionotropic, NMDA 2D	ISS	11319238	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IC	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00007	Axon guidance mediated by semaphorins	P00340	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00047	PDGF signaling pathway	P01173	STAT	MONDO|Ensembl=ENSMODG00000014816|UniProtKB=F7CHH2	Signal transducer and activator of transcription	ISS	14662325	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00005	Angiogenesis	P00256	PLC-gamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04570	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00775	Rac	ENTHI|EnsemblGenome=EHI_129750|UniProtKB=C4M5Q7	Rho family GTPase	TAS			PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00034	Integrin signalling pathway	P00951	Jnk	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06587	Nicotine pharmacodynamics pathway	P06590	GNG	MACMU|Ensembl=ENSMMUG00000010392|UniProtKB=F7ASR8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	HUMAN|HGNC=10935|UniProtKB=Q05940	Synaptic vesicular amine transporter	ISS	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P04398	p53 pathway feedback loops 2	P04657	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02744	Fructose galactose metabolism	P02965	UDP Glucose 4 epimerase	RAT|RGD=621493|UniProtKB=P18645	UDP-glucose 4-epimerase	RCA			PTHR43725:SF8	UDP-GLUCOSE 4-EPIMERASE
P00005	Angiogenesis	P00181	SHP2	BOVIN|Ensembl=ENSBTAG00000002048|UniProtKB=F1N339	Tyrosine-protein phosphatase non-receptor type	ISS	8096088	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P02738	De novo purine biosynthesis	P02907	dADP kinase	XENTR|Xenbase=XB-GENE-923233|UniProtKB=Q6AZK9	Nucleoside diphosphate kinase	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P00029	Huntington disease	P00807	Actin	YEAST|SGD=S000001855|UniProtKB=P60010	Actin	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00034	Integrin signalling pathway	P00920	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IPI	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00019	Endothelin signaling pathway	P00587	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00023	General transcription regulation	P00660	RNA Polymerase II	MACMU|Ensembl=ENSMMUG00000013927|UniProtKB=F6SMC2	Uncharacterized protein	ISS	11313498	gi	PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P00046	Oxidative stress response	P01133	Max	BOVIN|Ensembl=ENSBTAG00000017994|UniProtKB=A8E4Q8	MAX protein	ISS	11274345	PubMed	PTHR10328:SF3	PROTEIN MAX
P00035	Interferon-gamma signaling pathway	P00958	PIAS	RAT|RGD=71056|UniProtKB=Q6AZ28	E3 SUMO-protein ligase PIAS2	ISS	8682149	PubMed	PTHR10782:SF12	E3 SUMO-PROTEIN LIGASE PIAS2
P00013	Cell cycle	P00480	Proteasome	SCHPO|PomBase=SPBC119.01|UniProtKB=O42897	Probable 26S proteasome regulatory subunit rpn3	ISS	21848401	PubMed	PTHR10758:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00015	Circadian clock system	P00502	Casein kinase I	HUMAN|HGNC=2453|UniProtKB=P49674	Casein kinase I isoform epsilon	ISS	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00951	Jnk	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01153	GSK3	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	HUMAN|HGNC=130|UniProtKB=P62736	Actin, aortic smooth muscle	IC	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01275	P38	DANRE|ZFIN=ZDB-GENE-990415-257|UniProtKB=O42376	Mitogen-activated protein kinase 12	TAS	11274345	PubMed	PTHR24055:SF339	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00047	PDGF signaling pathway	P01161	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00644	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IGI	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	RAT|RGD=69430|UniProtKB=P32851	Syntaxin-1A	IC	1321498	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000021808|UniProtKB=Q9MZL3	Voltage-dependent L-type calcium channel subunit beta-3	IC			PTHR11824:SF8	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-3
P00049	Parkinson disease	P01208	Hsp70	NEUCR|EnsemblGenome=EFNCRG00000003675|UniProtKB=P78695	78 kDa glucose-regulated protein homolog	IDA	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CANLF|Gene=MYH1|UniProtKB=Q076A6	Myosin-1	ISS	10938134	PubMed	PTHR13140:SF484	MYOSIN-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	RCA	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00846	JAK	BOVIN|Ensembl=ENSBTAG00000012047|UniProtKB=E1BCP6	Tyrosine-protein kinase	ISS	22482294	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00006	Apoptosis signaling pathway	P00274	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05913	Enkephalin release	P05972	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00011	Blood coagulation	P00436	GP 1bbeta	MOUSE|MGI=MGI=107852|UniProtKB=P56400	Platelet glycoprotein Ib beta chain	ISS	87326405	PubMed	PTHR22650:SF7	PLATELET GLYCOPROTEIN IB BETA CHAIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	XENTR|Xenbase=XB-GENE-956713|UniProtKB=Q5XGD8	Guanine nucleotide binding protein, beta 3	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	BOVIN|Ensembl=ENSBTAG00000010830|UniProtKB=E1BGJ0	Uncharacterized protein	ISS	11907044	PubMed	PTHR44025:SF2	PROLOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	ARATH|TAIR=AT5G44340|UniProtKB=P24636	Tubulin beta-4 chain	ISS	9454836	PubMed	PTHR11588:SF245	TUBULIN BETA-4 CHAIN-RELATED
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=3025|UniProtKB=P21917	D(4) dopamine receptor	IDA	2039532	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00007	Axon guidance mediated by semaphorins	P00341	Rho	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	ISS	12039949	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00021	FGF signaling pathway	P00642	MEK1-2	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04393	Ras Pathway	P04543	MEKK1/4	PANTR|Ensembl=ENSPTRG00000016891|UniProtKB=H2R5K3	Uncharacterized protein	ISS	12168099	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	PANTR|Gene=CHRM2|UniProtKB=Q9N2A7	Muscarinic acetylcholine receptor M2 (Fragment)	ISS	8100450	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01444	Wnt	BRAFL|Gene=BRAFLDRAFT_113720|UniProtKB=C3YYJ8	Protein Wnt	IDA	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	TAS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00047	PDGF signaling pathway	P01142	p90RSK	CANLF|Ensembl=ENSCAFG00000000828|UniProtKB=F6UWI0	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IDA	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DANRE|ZFIN=ZDB-GENE-041001-104|UniProtKB=Q5TZD4	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00010	B cell activation	P00391	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01143	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	G01532	PolyQ HTT	CANLF|Ensembl=ENSCAFG00000014682|UniProtKB=F1P7Y7	Uncharacterized protein	ISS	9462744	PubMed	PTHR10170:SF10	HUNTINGTIN
P02766	Phenylethylamine degradation	P03103	Phenylethylamine oxidase	HUMAN|HGNC=80|UniProtKB=P19801	Amiloride-sensitive amine oxidase [copper-containing]	ISS			PTHR10638:SF3	AMILORIDE-SENSITIVE AMINE OXIDASE  COPPER-CONTAINING
P00005	Angiogenesis	P00237	FRP	MACMU|Ensembl=ENSMMUG00000007486|UniProtKB=F6QL95	Frizzled-3	ISS	11212302	PubMed	PTHR11309:SF22	FRIZZLED-3
P00029	Huntington disease	P00790	beta-Tubulin	TAKRU|Ensembl=ENSTRUG00000005446|UniProtKB=H2SKZ5	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00019	Endothelin signaling pathway	P00591	PLCbeta	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	HUMAN|HGNC=11433|UniProtKB=Q16623	Syntaxin-1A	ISS	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P04393	Ras Pathway	P04547	Ras	CAEBR|Gene=CBG06092|UniProtKB=A8X0X5	Protein CBR-LET-60	ISS	12024031	PubMed	PTHR24070:SF385	GTPASE HRAS
P00034	Integrin signalling pathway	P00916	Ras	MONDO|Ensembl=ENSMODG00000025248|UniProtKB=F7F5X1	Uncharacterized protein	ISS	3023884	PubMed	PTHR24070:SF186	GTPASE KRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	CAEEL|WormBase=WBGene00001679|UniProtKB=P17343	Guanine nucleotide-binding protein subunit beta-1	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00053	T cell activation	P01300	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00757	beta-arrestin	MACMU|Ensembl=ENSMMUG00000023359|UniProtKB=F7E8B5	Uncharacterized protein	ISS	10206946	PubMed	PTHR11792:SF15	S-ARRESTIN
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	METJA|EnsemblGenome=MJ_1265|UniProtKB=Q58661	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02769	Purine metabolism	P03116	Xanthine Oxidase	HUMAN|HGNC=12805|UniProtKB=P47989	Xanthine dehydrogenase/oxidase	ISS	8708081	PubMed	PTHR11908:SF80	XANTHINE DEHYDROGENASE/OXIDASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	CANLF|Ensembl=ENSCAFG00000018170|UniProtKB=E2RPM8	Tyrosine-protein kinase receptor	ISS	14500580	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00051	TCA cycle	P01268	Aconitase	DROME|FlyBase=FBgn0010100|UniProtKB=Q9VIE8	Aconitate hydratase, mitochondrial	RCA			PTHR43160:SF3	ACONITATE HYDRATASE, MITOCHONDRIAL
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00036	Interleukin signaling pathway	P00968	Ikk	CANLF|Ensembl=ENSCAFG00000005526|UniProtKB=E2RKR0	Uncharacterized protein	ISS	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00020	FAS signaling pathway	P00615	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00006	Apoptosis signaling pathway	P00287	TNFR2	MOUSE|MGI=MGI=1314883|UniProtKB=P25119	Tumor necrosis factor receptor superfamily member 1B	ISS	7990930	PubMed	PTHR23097:SF120	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1B
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	DAPPU|EnsemblGenome=DAPPUDRAFT_206575|UniProtKB=E9FUX0	Guanine nucleotide binding protein, beta subunit	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00060	Ubiquitin proteasome pathway	P01490	E3	HUMAN|HGNC=16803|UniProtKB=Q15386	Ubiquitin-protein ligase E3C	ISS			PTHR11254:SF357	UBIQUITIN-PROTEIN LIGASE E3C
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00029	Huntington disease	P00767	Pro-caspase 8	MACMU|Ensembl=ENSMMUG00000031296|UniProtKB=F7C587	Uncharacterized protein	ISS	11788820	PubMed	PTHR10454:SF162	CASPASE-8
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04393	Ras Pathway	P04572	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01465	Ggamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	22533439	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	DROME|FlyBase=FBgn0002413|UniProtKB=O76324	Discs overgrown protein kinase	IDA	14712927	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IDA	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00011	Blood coagulation	P00409	PAI-2	PANTR|Ensembl=ENSPTRG00000023897|UniProtKB=H2QEN1	Uncharacterized protein	ISS	11929770	PubMed	PTHR11461:SF61	PLASMINOGEN ACTIVATOR INHIBITOR 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	BOVIN|Ensembl=ENSBTAG00000047856|UniProtKB=G3MZE2	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	IDA	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00005	Angiogenesis	P00243	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01375	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00916	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	BOVIN|Ensembl=ENSBTAG00000011761|UniProtKB=F1MDE1	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TAKRU|Ensembl=ENSTRUG00000005494|UniProtKB=P53483	Actin, alpha anomalous	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000020425|UniProtKB=H2QWF6	Uncharacterized protein	ISS	8120095	PubMed	PTHR44603:SF2	CADHERIN-17
P00048	PI3 kinase pathway	P01179	PKB	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00054	Toll receptor signaling pathway	P01369	MKK1	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	CANLF|Ensembl=ENSCAFG00000015662|UniProtKB=E2RHY4	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00005	Angiogenesis	P00200	Dsh	MACMU|Ensembl=ENSMMUG00000010542|UniProtKB=F7D0L2	Segment polarity protein dishevelled homolog DVL-2	ISS	10409711	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P02788	Xanthine and guanine salvage pathway	P03248	Deoxyguanosine phosphorylase	THEMA|EnsemblGenome=TM_1737|UniProtKB=Q9X259	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	ARATH|TAIR=AT4G23900|UniProtKB=Q8LAH8	Nucleoside diphosphate kinase IV, chloroplastic/mitochondrial	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00052	TGF-beta signaling pathway	P01275	P38	CAEBR|Gene=CBG01555|UniProtKB=A8WRD7	Mitogen-activated protein kinase	ISS	22138445	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P05915	Opioid proenkephalin pathway	P05990	K+ channel	CHICK|Ensembl=ENSGALG00000016193|UniProtKB=E1BYI0	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00052	TGF-beta signaling pathway	P01275	P38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	TAS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00034	Integrin signalling pathway	P00924	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00005	Angiogenesis	P00251	cPLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00054	Toll receptor signaling pathway	P01368	MKK2	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000005909|UniProtKB=H2Q7M1	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF46	PROTOCADHERIN-8
P02779	Thiamin biosynthesis	P03175	1-Deoxyxylulose-5-phosphate synthase	CHLTR|EnsemblGenome=CT_331|UniProtKB=O84335	1-deoxy-D-xylulose-5-phosphate synthase	ISS			PTHR43322:SF6	1-DEOXY-D-XYLULOSE-5-PHOSPHATE SYNTHASE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-010705-1|UniProtKB=Q90Z40	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CHICK|Gene=ACTG2|UniProtKB=P63270	Actin, gamma-enteric smooth muscle	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01168	PI3K	XENTR|Xenbase=XB-GENE-6067221|UniProtKB=F6Z0J4	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01006	NR2C	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS			PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00048	PI3 kinase pathway	P01182	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	TAS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00010	B cell activation	P00379	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	MOUSE|MGI=MGI=1298218|UniProtKB=O88572	Low-density lipoprotein receptor-related protein 6	IDA	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00010	B cell activation	P00391	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01188	Gbetagamma	ANOGA|EnsemblGenome=AGAP005912|UniProtKB=Q7Q6D3	AGAP005912-PA	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	IDA	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-2280|UniProtKB=Q6P025	Gnb3 protein	ISS			PTHR19850:SF35	GNB3 PROTEIN
P00053	T cell activation	P01315	Calcineurin	CANLF|Ensembl=ENSCAFG00000010644|UniProtKB=F2Z4P5	Serine/threonine-protein phosphatase	ISS	12091710	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04376	5HT4 type receptor mediated signaling pathway	P04426	K+ channel	CHICK|Ensembl=ENSGALG00000016193|UniProtKB=E1BYI0	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MOUSE|MGI=MGI=1928896|UniProtKB=Q9R0Q6	Actin-related protein 2/3 complex subunit 1A	ISS	12473693	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00015	Circadian clock system	P00505	Cry	DANRE|ZFIN=ZDB-GENE-010426-8|UniProtKB=F1QHM9	Uncharacterized protein	ISS			PTHR11455:SF9	6-4 -PHOTOLYASE, ISOFORM A
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	SCHPO|PomBase=SPBP35G2.05c|UniProtKB=P40234	Casein kinase I homolog 2	IDA	10617630	PubMed	PTHR11909:SF155	GILGAMESH, ISOFORM L
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IC	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00034	Integrin signalling pathway	P00914	Filamin	BOVIN|Ensembl=ENSBTAG00000022004|UniProtKB=E1BKX7	Uncharacterized protein	ISS	9722563	PubMed	PTHR43998:SF3	FILAMIN-B
P00036	Interleukin signaling pathway	P00990	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MACMU|Ensembl=ENSMMUG00000001353|UniProtKB=F7D6T8	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00011	Blood coagulation	P00429	PN2	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	ISS	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	BOVIN|Ensembl=ENSBTAG00000013298|UniProtKB=A4IFJ5	Cytosolic phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00053	T cell activation	P01306	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00059	p53 pathway	P04635	Sumo-1 ligase	MOUSE|MGI=MGI=1336201|UniProtKB=Q9Z172	Small ubiquitin-related modifier 3	ISS			PTHR10562:SF50	SMALL UBIQUITIN-RELATED MODIFIER 3
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g187791|UniProtKB=A7SB93	Predicted protein	ISS			PTHR24070:SF263	RAS-LIKE PROTEIN 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01407	Erk	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00776	c-Jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	11840290	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P05731	GABA-B receptor II signaling	P05755	Gbeta	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CHICK|Ensembl=ENSGALG00000006576|UniProtKB=E1BUE5	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	IDA	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04393	Ras Pathway	P04579	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	7680960	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00005	Angiogenesis	P00243	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00045	Notch signaling pathway	P01103	Next	MOUSE|MGI=MGI=1095416|UniProtKB=Q9QXX0	Protein jagged-1	IPI	10551863	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ARATH|TAIR=AT2G42090|UniProtKB=P93738	Putative actin-9	IC	10974003	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00029	Huntington disease	P00780	Microtubule	PANTR|Ensembl=ENSPTRG00000010369|UniProtKB=H2QF52	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF253	TUBULIN BETA-4A CHAIN
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00059	p53 pathway	G04694	p110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01414	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05913	Enkephalin release	P05977	G-Protein (s)	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	MOUSE|MGI=MGI=96575|UniProtKB=P15208	Insulin receptor	ISS	11182407	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00021	FGF signaling pathway	P00644	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01451	Galpha	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02752	Mannose metabolism	P03018	Mannose 1-P guanylyl transferase	MACMU|Ensembl=ENSMMUG00000017938|UniProtKB=F6QZY6	Mannose-1-phosphate guanyltransferase alpha	ISS	12477932	PubMed	PTHR22572:SF104	MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8672|UniProtKB=Q9UN73	Protocadherin alpha-6	IDA	8120095	PubMed	PTHR24028:SF231	PROTOCADHERIN ALPHA-6
P00057	Wnt signaling pathway	P01471	alpha-catenin	CANLF|Ensembl=ENSCAFG00000001315|UniProtKB=E2R9S7	Uncharacterized protein	ISS	1768802	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8705|UniProtKB=Q9Y5G6	Protocadherin gamma-A7	IDA	8120095	PubMed	PTHR24028:SF56	PROTOCADHERIN GAMMA-A7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00021	FGF signaling pathway	P00629	PP2A	BOVIN|Ensembl=ENSBTAG00000020192|UniProtKB=A4FV55	PPP2R5C protein	ISS	10092233	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	CHICK|Gene=BMP4|UniProtKB=Q90752	Bone morphogenetic protein 4	TAS	9759503	PubMed	PTHR11848:SF165	BONE MORPHOGENETIC PROTEIN 4
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	BOVIN|Gene=MMP13|UniProtKB=O77656	Collagenase 3	TAS	Fang,Y.,Kitchell,B.E.,Paria,B.andBalkin,R.	free text	PTHR10201:SF165	COLLAGENASE 3
P00047	PDGF signaling pathway	P01162	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00037	Ionotropic glutamate receptor pathway	P01015	Glu4	MONDO|Ensembl=ENSMODG00000014746|UniProtKB=F6YN64	Uncharacterized protein (Fragment)	ISS	10331083	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00059	p53 pathway	P04630	PP2A	PANTR|Ensembl=ENSPTRG00000017238|UniProtKB=H2QRH7	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P05913	Enkephalin release	P05972	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	IDA	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00004	Alzheimer disease-presenilin pathway	P00117	E-cadherin C-terminal fragment	RAT|RGD=621089|UniProtKB=F1LMI3	Cadherin 3, type 1, P-cadherin (Placental)	ISS	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P00006	Apoptosis signaling pathway	P00288	TNFR1	BOVIN|Gene=TNFRSF1A|UniProtKB=O19131	Tumor necrosis factor receptor superfamily member 1A	ISS			PTHR23097:SF177	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1A
P00021	FGF signaling pathway	P00633	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P02743	Formyltetrahydroformate biosynthesis	P02953	Cobalamin dependent homocysteine transmethylase	SYNY3|EnsemblGenome=BAA10438|UniProtKB=Q55786	Methionine synthase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	PANTR|Ensembl=ENSPTRG00000004964|UniProtKB=H2Q5Y6	Receptor protein serine/threonine kinase	ISS	10683140	PubMed	PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P00059	p53 pathway	G04694	p110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00054	Toll receptor signaling pathway	P01360	IKKbeta	MACMU|Ensembl=ENSMMUG00000008351|UniProtKB=F7HRV5	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00056	VEGF signaling pathway	P01418	Paxillin	MOUSE|MGI=MGI=102784|UniProtKB=Q62219	Transforming growth factor beta-1-induced transcript 1 protein	ISS			PTHR24216:SF27	TRANSFORMING GROWTH FACTOR BETA-1-INDUCED TRANSCRIPT 1 PROTEIN
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05754	Ggamma	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01411	Ras	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g247341|UniProtKB=A7STP5	Predicted protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00507	Rho	CANLF|Ensembl=ENSCAFG00000015764|UniProtKB=F1PYF1	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF17	RHO-RELATED GTP-BINDING PROTEIN RHOJ
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	IC	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00793	Arfaptin-2	HUMAN|HGNC=17160|UniProtKB=P53365	Arfaptin-2	IDA	11854752	PubMed	PTHR12141:SF3	ARFAPTIN-2
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00591	PLCbeta	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04398	p53 pathway feedback loops 2	P04657	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00048	PI3 kinase pathway	P01185	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	MOUSE|MGI=MGI=1933206|UniProtKB=A2AIR5	Protein Grin3a	ISS	11319238	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00019	Endothelin signaling pathway	P00572	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PHYIT|EnsemblGenome=PITG_15078|UniProtKB=D0NRL5	Actin-like protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00005	Angiogenesis	P00243	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	CANLF|Ensembl=ENSCAFG00000002528|UniProtKB=F1PS63	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF61	TGF-BETA RECEPTOR TYPE-1
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000008867|UniProtKB=H2QCF3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00047	PDGF signaling pathway	P01172	c-Myc	HUMAN|HGNC=7553|UniProtKB=P01106	Myc proto-oncogene protein	ISS	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P06959	CCKR signaling map	P07220	A-Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	RCA	15710605	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00012	Cadherin signaling pathway	P00466	EGFR	CANLF|Gene=ERBB2|UniProtKB=O18735	Receptor tyrosine-protein kinase erbB-2	ISS	2575867	gi	PTHR24416:SF137	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2
P00005	Angiogenesis	P00193	SOS-1	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	HUMAN|HGNC=1401|UniProtKB=Q02641	Voltage-dependent L-type calcium channel subunit beta-1	IC	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008422|UniProtKB=F6VUT7	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	RAT|RGD=2027|UniProtKB=P63269	Actin, gamma-enteric smooth muscle	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05731	GABA-B receptor II signaling	P05760	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	PANTR|Ensembl=ENSPTRG00000017236|UniProtKB=H2QRH6	Uncharacterized protein	ISS	9118222	PubMed	PTHR10373:SF33	TRANSCRIPTION FACTOR 7
P00049	Parkinson disease	P01219	SAPK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00005	Angiogenesis	P00206	Wnt	CANLF|Ensembl=ENSCAFG00000008760|UniProtKB=E2RTG8	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06739	MEK1/2	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	RCA	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00005	Angiogenesis	P00211	GSK3beta	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	BOVIN|Ensembl=ENSBTAG00000001137|UniProtKB=P04973	Clathrin light chain A	IDA	9388255	PubMed	PTHR10639:SF1	CLATHRIN LIGHT CHAIN A
P02787	Vitamin B6 metabolism	P03244	Pyridoxal kinase	MACMU|Ensembl=ENSMMUG00000012300|UniProtKB=F7DLS4	Uncharacterized protein	ISS	15082224	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	CHICK|Ensembl=ENSGALG00000012894|UniProtKB=P30372	Muscarinic acetylcholine receptor M2	TAS	10069496	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00029	Huntington disease	P00805	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00786	ARF	MONDO|Ensembl=ENSMODG00000013804|UniProtKB=F6SY88	Uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF294	ADP-RIBOSYLATION FACTOR 3
P00006	Apoptosis signaling pathway	P00318	PKCs	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347742|UniProtKB=E9FZ00	Cytoplasmatic actin	ISS	11889126	PubMed	PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00021	FGF signaling pathway	P00631	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12186904	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04626	GADD45	BOVIN|Ensembl=ENSBTAG00000013860|UniProtKB=Q3ZBN6	Growth arrest and DNA damage-inducible protein GADD45 alpha	ISS	10097101	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	MOUSE|MGI=MGI=97364|UniProtKB=O35516	Neurogenic locus notch homolog protein 2	IDA	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	RAT|RGD=3910|UniProtKB=P04652	Thyrotropin subunit beta	ISS	15927770	PubMed	PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P00049	Parkinson disease	P01211	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00054	Toll receptor signaling pathway	P01369	MKK1	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00780	Microtubule	MACMU|Ensembl=ENSMMUG00000029059|UniProtKB=F6QAX2	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	IC	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00167	CD44 transmembrane fragment	PANTR|Ensembl=ENSPTRG00000003501|UniProtKB=H2Q3E8	Uncharacterized protein	ISS	12223485	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P00036	Interleukin signaling pathway	P00981	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	TAS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02746	Heme biosynthesis	P02983	Hydroxymethylbilane synthase	SULSO|EnsemblGenome=SSO0183|UniProtKB=Q980U4	Probable porphobilinogen deaminase	ISS			PTHR11557:SF0	PORPHOBILINOGEN DEAMINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00128	Erb-B4	MACMU|Ensembl=ENSMMUG00000001674|UniProtKB=F7G3H1	Receptor protein-tyrosine kinase	ISS	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	HUMAN|HGNC=1951|UniProtKB=P08172	Muscarinic acetylcholine receptor M2	ISS	8100450	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P06959	CCKR signaling map	P07213	c-RAF / RAF1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	RCA	15520807	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	MACMU|Ensembl=ENSMMUG00000000612|UniProtKB=F7CDE0	Nucleoside diphosphate kinase	ISS			PTHR11349:SF49	NUCLEOSIDE DIPHOSPHATE KINASE, MITOCHONDRIAL
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	BOVIN|Ensembl=ENSBTAG00000000219|UniProtKB=F1MCL3	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04393	Ras Pathway	P04557	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IDA	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00030	Hypoxia response via HIF activation	P00823	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	12660731	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	RAT|RGD=1306246|UniProtKB=D3ZZN3	Acetyl-coenzyme A synthetase	ISS			PTHR24095:SF110	ACETYL-COENZYME A SYNTHETASE 2-LIKE, MITOCHONDRIAL
P00013	Cell cycle	P00480	Proteasome	MOUSE|MGI=MGI=1914247|UniProtKB=Q9D8W5	26S proteasome non-ATPase regulatory subunit 12	ISS	12477932	PubMed	PTHR10855:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12
P00052	TGF-beta signaling pathway	P01288	FKBP12	CANLF|Ensembl=ENSCAFG00000014572|UniProtKB=E2R9R5	Peptidyl-prolyl cis-trans isomerase	ISS			PTHR10516:SF333	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP2
P00046	Oxidative stress response	P01136	Elk-1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	TAS	10487205	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00021	FGF signaling pathway	P00633	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IGI	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	RCA	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00005	Angiogenesis	P00211	GSK3beta	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05913	Enkephalin release	P05972	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MACMU|Ensembl=ENSMMUG00000006253|UniProtKB=F7H582	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P02738	De novo purine biosynthesis	P02889	dGDP kinase	LEIMA|EnsemblGenome=LmjF.32.2950|UniProtKB=Q9U1E1	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00036	Interleukin signaling pathway	P00996	STAT	MOUSE|MGI=MGI=103036|UniProtKB=P42230	Signal transducer and activator of transcription 5A	IC	22320921	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00034	Integrin signalling pathway	P00931	Integrin beta	XENTR|Xenbase=XB-GENE-1009964|UniProtKB=F6SRR1	Integrin beta (Fragment)	ISS	2119641	gi	PTHR10082:SF25	INTEGRIN BETA-3
P05912	Dopamine receptor mediated signaling pathway	P05957	K+ channel	MACMU|Ensembl=ENSMMUG00000005826|UniProtKB=F6VE51	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01148	Grb2	MOUSE|MGI=MGI=1918770|UniProtKB=Q9CX99	GRB2-related adapter protein	ISS	51702266	gi	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_126324|UniProtKB=C3XYC2	Putative uncharacterized protein	IDA	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	XENTR|Xenbase=XB-GENE-6469705|UniProtKB=Q6P8G3	Actin, alpha sarcomeric/skeletal	ISS	14684598	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00634	MEKK1-5	PANTR|Ensembl=ENSPTRG00000024326|UniProtKB=H2R231	Uncharacterized protein	ISS	12697749	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CHICK|Ensembl=ENSGALG00000009287|UniProtKB=O93602	Cyclic AMP-dependent transcription factor ATF-2	TAS	11390664	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P02723	Adenine and hypoxanthine salvage pathway	P02807	Deoxyadenosine deaminase	PANTR|Ensembl=ENSPTRG00000013524|UniProtKB=H2QKE6	Adenosine deaminase	ISS			PTHR11409:SF43	ADENOSINE DEAMINASE
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P02743	Formyltetrahydroformate biosynthesis	P02953	Cobalamin dependent homocysteine transmethylase	MYCTU|EnsemblGenome=Rv2124c|UniProtKB=O33259	Methionine synthase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P00034	Integrin signalling pathway	P00942	Fyn	RAT|RGD=2641|UniProtKB=Q62844	Tyrosine-protein kinase Fyn	IPI	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00060	Ubiquitin proteasome pathway	P01491	E2	HUMAN|HGNC=12488|UniProtKB=P68036	Ubiquitin-conjugating enzyme E2 L3	ISS	10888878	PubMed	PTHR24068:SF67	UBIQUITIN-CONJUGATING ENZYME E2 L3
P00029	Huntington disease	P00790	beta-Tubulin	BOVIN|Ensembl=ENSBTAG00000004093|UniProtKB=Q6B856	Tubulin beta-2B chain	ISS	12932731	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00057	Wnt signaling pathway	P01465	Ggamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01446	Calcineurin	MONDO|Ensembl=ENSMODG00000020679|UniProtKB=F7DKU1	Serine/threonine-protein phosphatase	ISS	12091710	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04623	CBP	MOUSE|MGI=MGI=1276116|UniProtKB=B2RWS6	Histone acetyltransferase p300	ISS	8413673	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHICK|Ensembl=ENSGALG00000009621|UniProtKB=P60706	Actin, cytoplasmic 1	ISS	11889139	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	MOUSE|MGI=MGI=97364|UniProtKB=O35516	Neurogenic locus notch homolog protein 2	IDA	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00029	Huntington disease	P00810	GAPDH	ORYSJ|EnsemblGenome=OS04G0486600|UniProtKB=Q7FAH2	Glyceraldehyde-3-phosphate dehydrogenase 2, cytosolic	ISS			PTHR10836:SF76	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE A
P04398	p53 pathway feedback loops 2	P04669	ATM	SCHPO|PomBase=SPBC216.05|UniProtKB=Q02099	Protein kinase rad3	TAS	10196661	PubMed	PTHR11139:SF69	SERINE/THREONINE-PROTEIN KINASE ATR
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	TAKRU|Ensembl=ENSTRUG00000007253|UniProtKB=H2SZQ1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P05915	Opioid proenkephalin pathway	P05994	G-protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	11535291	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	RAT|RGD=1564414|UniProtKB=Q6IML7	DnaJ homolog subfamily C member 27	ISS			PTHR24073:SF269	DNAJ HOMOLOG SUBFAMILY C MEMBER 27
P00021	FGF signaling pathway	P00646	RasGAP	HUMAN|HGNC=9871|UniProtKB=P20936	Ras GTPase-activating protein 1	IGI	8270251	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00628	JNK1-3	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	DANRE|ZFIN=ZDB-GENE-000330-9|UniProtKB=Q90ZE4	Presenilin-2	IDA	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P05730	Endogenous cannabinoid signaling	P05751	Galpha	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	DROME|FlyBase=FBgn0019985|UniProtKB=P91685	Metabotropic glutamate receptor	IDA	9407094	PubMed	PTHR24060:SF137	METABOTROPIC GLUTAMATE RECEPTOR
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CAEEL|WormBase=WBGene00001519|UniProtKB=Q9U7D5	Muscarinic acetylcholine receptor gar-3	IDA	11166329	PubMed	PTHR43914:SF8	MUSCARINIC ACETYLCHOLINE RECEPTOR GAR-3
P00057	Wnt signaling pathway	P01457	GBeta	ANOGA|EnsemblGenome=AGAP005912|UniProtKB=Q7Q6D3	AGAP005912-PA	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00547	PP2A	RAT|RGD=1305657|UniProtKB=A0A0G2JTA1	Protein Ppp2r5e	ISS	8703017	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	XENTR|Xenbase=XB-GENE-480800|UniProtKB=F6VM33	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF90	FRIZZLED-8
P00053	T cell activation	P01309	fos	MACMU|Ensembl=ENSMMUG00000010574|UniProtKB=A5A6H2	C-fos	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=1921305|UniProtKB=Q8K4S1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	12860966	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00019	Endothelin signaling pathway	P00570	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01456	beta-arrestin	PANTR|Ensembl=ENSPTRG00000004079|UniProtKB=H2R1Z2	Uncharacterized protein	ISS	11742073	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P05912	Dopamine receptor mediated signaling pathway	P05961	DOPA decarb.	DROME|FlyBase=FBgn0050446|UniProtKB=A1Z6N4	MIP05841p	ISS			PTHR11999:SF70	MIP05841P
P00004	Alzheimer disease-presenilin pathway	P00114	actin	NEUCR|EnsemblGenome=EFNCRG00000003893|UniProtKB=P78711	Actin	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	PANTR|Ensembl=ENSPTRG00000022245|UniProtKB=H2QZ29	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	ANOGA|Gene=AgaP_AGAP011360|UniProtKB=Q7Q2V9	AGAP011360-PA (Fragment)	ISS	4757780	gi	PTHR11792:SF17	KURTZ ARRESTIN
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00927	Rac	DICPU|Gene=DICPUDRAFT_92985|UniProtKB=F1A084	Putative uncharacterized protein rac1A	ISS	4757952	gi	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00053	T cell activation	P01300	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00022	General transcription by RNA polymerase I	P00651	TAF-IA	ARATH|TAIR=AT4G34340|UniProtKB=Q9SYZ9	Transcription initiation factor TFIID subunit 8	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	CANLF|Ensembl=ENSCAFG00000004930|UniProtKB=E2RFB5	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	XENTR|Xenbase=XB-GENE-494448|UniProtKB=L7N3H9	Uncharacterized protein (Fragment)	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P00004	Alzheimer disease-presenilin pathway	P00114	actin	IXOSC|EnsemblGenome=ISCW024111|UniProtKB=B7PBG2	Actin, putative (Fragment)	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00053	T cell activation	P01335	jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00029	Huntington disease	P00790	beta-Tubulin	PANTR|Ensembl=ENSPTRG00000017674|UniProtKB=H2Q189	Uncharacterized protein	TAS	9454836	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00021	FGF signaling pathway	P00648	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00181	SHP2	TAKRU|Ensembl=ENSTRUG00000018529|UniProtKB=H2VDZ2	Tyrosine-protein phosphatase non-receptor type	ISS	14534538	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00010	B cell activation	P00383	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	XENTR|Ensembl=ENSXETG00000021375|UniProtKB=F6T423	Uncharacterized protein	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	METJA|EnsemblGenome=MJ_1265|UniProtKB=Q58661	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00012	Cadherin signaling pathway	P00462	Casein kinase II	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g245041|UniProtKB=A7SG27	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P05913	Enkephalin release	P05972	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MOUSE|MGI=MGI=95822|UniProtKB=Q01098	Glutamate receptor ionotropic, NMDA 2C	ISS	11319238	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	BOVIN|Gene=SLC18A2|UniProtKB=Q27963	Synaptic vesicular amine transporter	ISS	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00054	Toll receptor signaling pathway	P01358	ERK1	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	TAKRU|Ensembl=ENSTRUG00000005447|UniProtKB=P68142	Actin, cytoplasmic 1	IDA	14684598	PubMed	PTHR11937:SF354	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P02725	Allantoin degradation	P02822	Allantoinase	ARATH|TAIR=AT4G04955|UniProtKB=Q94AP0	Allantoinase	ISS			PTHR43668:SF2	ALLANTOINASE
P00047	PDGF signaling pathway	P01162	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04398	p53 pathway feedback loops 2	G04708	WIP-1	RAT|RGD=1305460|UniProtKB=B1WCA0	Ppm1d protein	ISS			PTHR13832:SF359	PROTEIN PHOSPHATASE 1D
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	DANRE|Ensembl=ENSDARG00000070511|UniProtKB=E7F5R2	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF282	GLUTAMATE RECEPTOR-RELATED
P00029	Huntington disease	P00778	NMDA receptor	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00047	PDGF signaling pathway	P01153	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00056	VEGF signaling pathway	P01407	Erk	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04559	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12176041	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00004	Alzheimer disease-presenilin pathway	P00165	E-cadherin N-terminal fragment	HUMAN|HGNC=1748|UniProtKB=P12830	Cadherin-1	TAS	12834808	PubMed	PTHR24027:SF319	CADHERIN-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	CAEEL|WormBase=WBGene00002173|UniProtKB=Q9Y0A1	Inositol 1,4,5-trisphosphate receptor itr-1	ISS	4262086	gi	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=2652894|UniProtKB=Q80Y86	Mitogen-activated protein kinase 15	ISS	10514528	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00012	Cadherin signaling pathway	P00474	Wnt	CANLF|Ensembl=ENSCAFG00000005291|UniProtKB=E2QXQ3	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00035	Interferon-gamma signaling pathway	P00960	PTP	RAT|RGD=620660|UniProtKB=P81718	Tyrosine-protein phosphatase non-receptor type 6	TAS	14525967	PubMed	PTHR19134:SF65	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 6
P02765	Phenylalanine biosynthesis	P03101	Aromatic amino acid aminotransferase	ECOLI|EcoGene=EG11040|UniProtKB=P04693	Aromatic-amino-acid aminotransferase	ISS			PTHR11879:SF10	ASPARTATE AMINOTRANSFERASE
P05913	Enkephalin release	P05977	G-Protein (s)	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	HUMAN|HGNC=7159|UniProtKB=P45452	Collagenase 3	TAS	8207000	PubMed	PTHR10201:SF165	COLLAGENASE 3
P00006	Apoptosis signaling pathway	P00313	IKK	PANTR|Ensembl=ENSPTRG00000033948|UniProtKB=H2RBD4	Conserved helix-loop-helix ubiquitous kinase	ISS	14499113	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P04397	p53 pathway by glucose deprivation	P04639	AMPK	MOUSE|MGI=MGI=2145955|UniProtKB=Q5EG47	5'-AMP-activated protein kinase catalytic subunit alpha-1	ISS			PTHR24343:SF306	5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95814|UniProtKB=Q60934	Glutamate receptor ionotropic, kainate 1	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00005	Angiogenesis	P00236	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DICDI|dictyBase=DDB_G0279413|UniProtKB=P05987	cAMP-dependent protein kinase regulatory subunit	IC	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00539	14-3-3	CANLF|Ensembl=ENSCAFG00000000580|UniProtKB=F1PBL1	Uncharacterized protein	ISS	1499718	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BOVIN|Gene=ACTB|UniProtKB=P60712	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00059	p53 pathway	P04633	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	ARATH|TAIR=AT5G07880|UniProtKB=Q9SD96	SNAP25 homologous protein SNAP29	IC			PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00059	p53 pathway	P04610	Cyclin E	MACMU|Ensembl=ENSMMUG00000020668|UniProtKB=F7BEI4	Uncharacterized protein	ISS	12729791	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00005	Angiogenesis	P00244	MAPKAPK2/3	MOUSE|MGI=MGI=2143163|UniProtKB=Q3UMW7	MAP kinase-activated protein kinase 3	ISS	11335727	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04560	AP1	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00047	PDGF signaling pathway	P01162	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00018	EGF receptor signaling pathway	P00552	Ras	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	IGI	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00005	Angiogenesis	P00210	eNOS	RAT|RGD=3186|UniProtKB=Q62600	Nitric oxide synthase, endothelial	ISS	10435050	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00005	Angiogenesis	P00219	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00020	FAS signaling pathway	P00615	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00053	T cell activation	P01322	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8973|UniProtKB=O75747	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS			PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00006	Apoptosis signaling pathway	P00266	SEK1	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MACMU|Ensembl=ENSMMUG00000005185|UniProtKB=F7CYN6	Uncharacterized protein	ISS	9774420	PubMed	PTHR10845:SF184	REGULATOR OF G-PROTEIN SIGNALING 4
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	ORNAN|Ensembl=ENSOANG00000002406|UniProtKB=F7BAS2	Uncharacterized protein	ISS	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00029	Huntington disease	P00779	TBP	DROME|FlyBase=FBgn0010287|UniProtKB=Q27896	TBP-related factor	IPI	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00021	FGF signaling pathway	P00632	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	IGI	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02788	Xanthine and guanine salvage pathway	P03245	Guanine phosphoribosyl transferase	ARATH|TAIR=AT1G71750|UniProtKB=F4IA25	Hypoxanthine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01443	Phospholipase C	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	IDA	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00021	FGF signaling pathway	P00629	PP2A	DICDI|dictyBase=DDB_G0290263|UniProtKB=Q9XZE5	Serine/threonine-protein phosphatase 2A catalytic subunit A	IDA	10452519	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	MACMU|Ensembl=ENSMMUG00000022936|UniProtKB=F6U709	Uncharacterized protein	ISS	2137198	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	RAT|RGD=2743|UniProtKB=P31421	Metabotropic glutamate receptor 2	ISS	12351712	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P04393	Ras Pathway	P04559	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00048	PI3 kinase pathway	P01192	p110	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DANRE|ZFIN=ZDB-GENE-030131-55|UniProtKB=Q6XNL8	Actin	IC	11889139	PubMed	PTHR11937:SF263	ACTIN
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00012	Cadherin signaling pathway	P00462	Casein kinase II	MACMU|Ensembl=ENSMMUG00000015892|UniProtKB=F7BVK0	Uncharacterized protein	ISS	10617630	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	MOUSE|MGI=MGI=106217|UniProtKB=Q61290	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	14507926	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	YEAST|SGD=S000005738|UniProtKB=P18851	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00005	Angiogenesis	P00239	Eph	DANRE|ZFIN=ZDB-GENE-010618-1|UniProtKB=Q90Z32	Ephrin B2b	ISS			PTHR11304:SF48	EPHRIN B2B
P06664	Gonadotropin-releasing hormone receptor pathway	P06732	ATF2	MOUSE|MGI=MGI=109349|UniProtKB=P16951	Cyclic AMP-dependent transcription factor ATF-2	RCA	11390664	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00010	B cell activation	P00397	IKK	HUMAN|HGNC=5960|UniProtKB=O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	IGI	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00054	Toll receptor signaling pathway	P01369	MKK1	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01443	Phospholipase C	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00034	Integrin signalling pathway	P00912	Arp2/3	CANLF|Ensembl=ENSCAFG00000000132|UniProtKB=J9P309	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00057	Wnt signaling pathway	P01438	PP2A	HUMAN|HGNC=9300|UniProtKB=P62714	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	IDA	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P05912	Dopamine receptor mediated signaling pathway	P05960	VAT2	RAT|RGD=3694|UniProtKB=Q01827	Synaptic vesicular amine transporter	ISS	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MOUSE|MGI=MGI=1353466|UniProtKB=P57748	Matrix metalloproteinase-20	TAS	12834808	PubMed	PTHR10201:SF125	MATRIX METALLOPROTEINASE-20
P00047	PDGF signaling pathway	P01169	Vav	ANOGA|Gene_ORFName=AgaP_AGAP010292|UniProtKB=Q7PLZ7	AGAP010292-PA (Fragment)	ISS			PTHR22826:SF136	PROTEIN VAV
P05918	p38 MAPK pathway	P06017	MNK2	RAT|RGD=1305728|UniProtKB=Q5U2N4	MAP kinase-interacting serine/threonine-protein kinase 2	ISS	9155017	PubMed	PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000014751|UniProtKB=H2R8D8	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P04393	Ras Pathway	P04566	Stat 1/3	TAKRU|Ensembl=ENSTRUG00000000102|UniProtKB=H2RJA9	Signal transducer and activator of transcription	ISS	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P05731	GABA-B receptor II signaling	P05760	AC	MOUSE|MGI=MGI=1341110|UniProtKB=P97490	Adenylate cyclase type 8	RCA	8163524	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00010	B cell activation	P00381	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01443	Phospholipase C	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	TAKRU|Ensembl=ENSTRUG00000007253|UniProtKB=H2SZQ1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00018	EGF receptor signaling pathway	P00542	EGFR	MACMU|Gene=EGFR|UniProtKB=P55245	Epidermal growth factor receptor	ISS	90258888	PubMed	PTHR24416:SF91	EPIDERMAL GROWTH FACTOR RECEPTOR
P00059	p53 pathway	P04630	PP2A	TRIAD|EnsemblGenome=TriadG63380|UniProtKB=B3S653	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01230	Src kinase	ORNAN|Ensembl=ENSOANG00000005501|UniProtKB=F6X6I5	Tyrosine-protein kinase	ISS	1371009	PubMed	PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CAEBR|Gene=CBG18256|UniProtKB=A8XS95	Protein CBR-ACT-5	ISS	10974003	PubMed	PTHR11937:SF352	ACTIN
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02747	Histidine biosynthesis	P02991	Histidinephosphate aminotransferase	PSEAE|EnsemblGenome=PA3165|UniProtKB=Q9HZ68	Histidinol-phosphate aminotransferase 2	ISS			PTHR43643:SF3	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MOUSE|MGI=MGI=87905|UniProtKB=P68033	Actin, alpha cardiac muscle 1	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	CHICK|Gene=INHBA|UniProtKB=P27092	Inhibin beta A chain	TAS	11739336	PubMed	PTHR11848:SF133	INHIBIN BETA A CHAIN
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P06664	Gonadotropin-releasing hormone receptor pathway	G06904	5' FSHbeta	MOUSE|MGI=MGI=95582|UniProtKB=Q60687	Follitropin subunit beta	RCA			PTHR11515:SF17	FOLLITROPIN SUBUNIT BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	HUMAN|HGNC=143|UniProtKB=P68032	Actin, alpha cardiac muscle 1	IC	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04395	Vasopressin synthesis	P04594	Neurophysin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04397	p53 pathway by glucose deprivation	P04644	TSC2	MOUSE|MGI=MGI=102548|UniProtKB=Q61037	Tuberin	IDA	15249583	PubMed	PTHR10063:SF0	TUBERIN
P00029	Huntington disease	P00807	Actin	DICPU|Gene=DICPUDRAFT_90232|UniProtKB=F1A175	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	1499560	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P06959	CCKR signaling map	P07188	RHOA-GTP	HUMAN|HGNC=667|UniProtKB=P61586	Transforming protein RhoA	RCA	12771155	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01208	Hsp70	CHLRE|EnsemblGenome=CHLREDRAFT_126835|UniProtKB=A8HYV3	Heat shock protein 70B	IDA	12150907	PubMed	PTHR19375:SF147	HEAT SHOCK 70 KDA PROTEIN 6, CHLOROPLASTIC-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CHICK|Ensembl=ENSGALG00000014539|UniProtKB=F1N861	Uncharacterized protein	ISS	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	BOVIN|Ensembl=ENSBTAG00000003054|UniProtKB=F1MC23	Tyrosine-protein kinase receptor	ISS	10226785	PubMed	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00833	RGS	RAT|RGD=1306522|UniProtKB=Q4L0E8	Regulator of G-protein signaling 18	ISS	11563974	PubMed	PTHR10845:SF155	REGULATOR OF G-PROTEIN SIGNALING 18
P00034	Integrin signalling pathway	P00941	Integrin alpha	HUMAN|HGNC=6152|UniProtKB=P20702	Integrin alpha-X	IPI	3487386	PubMed	PTHR23220:SF118	INTEGRIN ALPHA-X
P04393	Ras Pathway	P04552	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00048	PI3 kinase pathway	P01189	PTEN	DICDI|dictyBase=DDB_G0286557|UniProtKB=Q8T9S7	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	TAS			PTHR12305:SF79	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	MOUSE|MGI=MGI=1917834|UniProtKB=Q8BTW9	Serine/threonine-protein kinase PAK 4	ISS			PTHR24361:SF345	SERINE/THREONINE-PROTEIN KINASE PAK 4
P00019	Endothelin signaling pathway	P00588	ET1-4	PANTR|Ensembl=ENSPTRG00000017730|UniProtKB=H2QSB1	Uncharacterized protein	ISS	12907686	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00976	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	P00547	PP2A	BOVIN|Ensembl=ENSBTAG00000009245|UniProtKB=Q0P594	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P04630	PP2A	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g195622|UniProtKB=A7T2Q5	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04395	Vasopressin synthesis	P04593	Glycopeptide	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	IC	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00029	Huntington disease	P00786	ARF	ORNAN|Ensembl=ENSOANG00000013982|UniProtKB=F6URT1	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00010	B cell activation	P00383	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00562	p38	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	IGI	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P05918	p38 MAPK pathway	P06044	GADD45	BOVIN|Ensembl=ENSBTAG00000013860|UniProtKB=Q3ZBN6	Growth arrest and DNA damage-inducible protein GADD45 alpha	ISS	9827804	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00012	Cadherin signaling pathway	P00474	Wnt	XENTR|Xenbase=XB-GENE-480396|UniProtKB=F7DI28	Protein Wnt (Fragment)	ISS	11266476	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	CAEBR|Gene=CBG_05938|UniProtKB=H8WGV2	Protein CBR-ITR-1, isoform a	ISS	4262086	gi	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P05913	Enkephalin release	P05972	PKA	DROME|FlyBase=FBgn0000489|UniProtKB=P16912	Protein kinase DC2	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00005	Angiogenesis	P00219	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS			PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00021	FGF signaling pathway	P00624	14-3-3	CHICK|Gene_ORFName=RCJMB04_1e8|UniProtKB=Q5ZMT0	14-3-3 protein epsilon	ISS	9450960	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	TAS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04393	Ras Pathway	P04567	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	RAT|RGD=1304556|UniProtKB=P63259	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF248	SUBFAMILY NOT NAMED
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04380	Cortocotropin releasing factor receptor signaling pathway	P04451	CRHR1	HUMAN|HGNC=2358|UniProtKB=Q13324	Corticotropin-releasing factor receptor 2	ISS	11145609	PubMed	PTHR12011:SF274	CORTICOTROPIN-RELEASING FACTOR RECEPTOR 2
P04393	Ras Pathway	P04542	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	STRCO|Gene=CAB94610|UniProtKB=Q9K3C2	Ribonucleoside-diphosphate reductase subunit beta	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DROME|FlyBase=FBgn0261854|UniProtKB=A1Z9X0	Atypical protein kinase C	IC	2837282	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00053	T cell activation	P01319	PAK	CHICK|Ensembl=ENSGALG00000000681|UniProtKB=E1C3P6	Uncharacterized protein	ISS	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00005	Angiogenesis	P00254	GTPase	DANRE|ZFIN=ZDB-GENE-040718-144|UniProtKB=Q6DHE8	Rho-related GTP-binding protein RhoA-D	ISS	12024019	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000023940|UniProtKB=F6RFW8	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00811	Arp2/3 complex	PANTR|Ensembl=ENSPTRG00000001767|UniProtKB=G2HG81	Actin-related protein 2/3 complex subunit 5	ISS	9230079	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00006	Apoptosis signaling pathway	P00310	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	9199552	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	PANTR|Ensembl=ENSPTRG00000000843|UniProtKB=H2QZN8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P02779	Thiamin biosynthesis	P03173	Thiamin phosphate synthase	RHOBA|EnsemblGenome=RB6331|UniProtKB=Q7UQH1	Thiamine-phosphate synthase	ISS			PTHR20857:SF15	THIAMINE BIOSYNTHETIC BIFUNCTIONAL ENZYME
P00056	VEGF signaling pathway	P01423	p38MAPK	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	HUMAN|HGNC=1392|UniProtKB=Q15878	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	8386525	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=4598|UniProtKB=O15303	Metabotropic glutamate receptor 6	IDA	11431030	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00005	Angiogenesis	P00256	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	11256888	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	PANTR|Ensembl=ENSPTRG00000009321|UniProtKB=H2QD96	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P04393	Ras Pathway	P04558	p38	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	8925912	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P02729	Ascorbate degradation	P02849	L-xylulose kinase	ARATH|TAIR=AT2G21370|UniProtKB=Q8L794	Putative xylulose kinase	ISS			PTHR10196:SF80	XYLULOSE KINASE-RELATED
P00011	Blood coagulation	P00450	Tissue Factor	HUMAN|HGNC=3541|UniProtKB=P13726	Tissue factor	ISS	8779717	PubMed	PTHR20859:SF22	TISSUE FACTOR
P00036	Interleukin signaling pathway	P00983	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MOUSE|MGI=MGI=95814|UniProtKB=Q60934	Glutamate receptor ionotropic, kainate 1	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	PANTR|Gene=CHRM3|UniProtKB=Q9N2A4	Muscarinic acetylcholine receptor M3	ISS	12915051	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00037	Ionotropic glutamate receptor pathway	P01020	NSF	SCHPO|PomBase=SPAC1834.11c|UniProtKB=Q9P7Q4	Vesicular-fusion protein sec18	ISS	11348590	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00019	Endothelin signaling pathway	P00572	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IGI	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00060	Ubiquitin proteasome pathway	P01491	E2	MOUSE|MGI=MGI=1915862|UniProtKB=Q9D1C1	Ubiquitin-conjugating enzyme E2 C	ISS			PTHR44189:SF1	UBIQUITIN-CONJUGATING ENZYME E2 C
P05912	Dopamine receptor mediated signaling pathway	P05955	DBH	MACMU|Ensembl=ENSMMUG00000017207|UniProtKB=F7HGF9	Uncharacterized protein	ISS	90219125	PubMed	PTHR10157:SF29	DOPAMINE BETA-HYDROXYLASE
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	HUMAN|HGNC=5291|UniProtKB=P28566	5-hydroxytryptamine receptor 1E	ISS	11701344	PubMed	PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P00030	Hypoxia response via HIF activation	P00819	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00912	Arp2/3	BOVIN|Ensembl=ENSBTAG00000010386|UniProtKB=Q3MHR7	Actin-related protein 2/3 complex subunit 2	IPI	12473693	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00047	PDGF signaling pathway	P01162	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05731	GABA-B receptor II signaling	P05754	Ggamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00015	Circadian clock system	P00504	Per	HUMAN|HGNC=8845|UniProtKB=O15534	Period circadian protein homolog 1	ISS	12782655	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00047	PDGF signaling pathway	P01171	PLCgamma	DROME|FlyBase=FBgn0003416|UniProtKB=Q9VXH3	Phosphoinositide phospholipase C	ISS			PTHR10336:SF91	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00019	Endothelin signaling pathway	P00578	eNOS	MACMU|Ensembl=ENSMMUG00000020437|UniProtKB=F6WEB2	Nitric oxide synthase	ISS	22462730	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	PHYPA|Gene=PHYPADRAFT_190505|UniProtKB=A9T0R6	Predicted protein	ISS			PTHR23073:SF8	26S PROTEASE REGULATORY SUBUNIT 6B
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00919	Arf6	TAKRU|Ensembl=ENSTRUG00000017307|UniProtKB=H2VAQ1	Uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00006	Apoptosis signaling pathway	P00310	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05913	Enkephalin release	P05972	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	NEUCR|EnsemblGenome=EFNCRG00000007504|UniProtKB=Q9C167	Ribonucleoside-diphosphate reductase small chain	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00024	Glycolysis	P00678	Enolase	MOUSE|MGI=MGI=95394|UniProtKB=P17183	Gamma-enolase	ISS	5803011	gi	PTHR11902:SF10	GAMMA-ENOLASE
P02757	O-antigen biosynthesis	P03052	N-acetylglucosamine-1-phosphate uridyltransferase	GLOVI|EnsemblGenome=BAC88384|UniProtKB=Q7NNG8	Bifunctional protein GlmU	ISS			PTHR43584:SF3	BIFUNCTIONAL PROTEIN GLMU
P00021	FGF signaling pathway	P00632	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	DROME|FlyBase=FBgn0265784|UniProtKB=Q9VWW0	Cyclic AMP response element-binding protein B	ISS	608972	OMIM	PTHR22952:SF248	CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN B
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	GIAIC|EnsemblGenome=GL50803_21942|UniProtKB=A8BFF8	Glutamate dehydrogenase	ISS			PTHR43571:SF1	NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED
P00019	Endothelin signaling pathway	P00590	IP3 R	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	IGI	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00019	Endothelin signaling pathway	P00583	cPLA2	MACMU|Ensembl=ENSMMUG00000021423|UniProtKB=F7EEZ1	Phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=11438|UniProtKB=Q13277	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MONDO|Ensembl=ENSMODG00000012331|UniProtKB=F7E2P1	Phosphoinositide phospholipase C	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P02772	Pyruvate metabolism	P03137	Citrate Lyase	BOVIN|Ensembl=ENSBTAG00000016740|UniProtKB=Q32PF2	ATP-citrate synthase	ISS			PTHR23118:SF0	ATP-CITRATE SYNTHASE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	22040490	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02734	Chorismate biosynthesis	P02868	Chorismate synthase	STRCO|EnsemblGenome=CAB93376|UniProtKB=Q9KXQ4	Chorismate synthase	ISS			PTHR21085:SF0	CHORISMATE SYNTHASE
P02785	Valine biosynthesis	P03218	Dihydroxy isovalerate dehydratase	ECOLI|EcoGene=EG13345|UniProtKB=P77596	Uncharacterized protein YagF	ISS			PTHR43661:SF2	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	MONDO|Ensembl=ENSMODG00000009266|UniProtKB=F7DA21	Protein-serine/threonine kinase	RCA			PTHR24355:SF27	G PROTEIN-COUPLED RECEPTOR KINASE 5
P00029	Huntington disease	P00775	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00005	Angiogenesis	P00223	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	DEIRA|EnsemblGenome=DR_0302|UniProtKB=Q9RXK9	Glutamine--fructose-6-phosphate aminotransferase [isomerizing]	ISS			PTHR10937:SF0	GH12731P-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IGI	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00034	Integrin signalling pathway	P00923	Arf1	MONDO|Ensembl=ENSMODG00000003056|UniProtKB=F6PNX7	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P00005	Angiogenesis	P00234	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12162872	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	IDA	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MOUSE|MGI=MGI=1336171|UniProtKB=Q9DAS9	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IDA	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00049	Parkinson disease	P01242	Casein kinase I	DROME|FlyBase=FBgn0002413|UniProtKB=O76324	Discs overgrown protein kinase	IDA	11955435	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00029	Huntington disease	P00778	NMDA receptor	MACMU|Ensembl=ENSMMUG00000019112|UniProtKB=F6T8S6	N-methyl D-aspartate receptor subtype 2B	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04398	p53 pathway feedback loops 2	P04665	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04564	MAPKAP	PANTR|Ensembl=ENSPTRG00000001915|UniProtKB=H2Q104	Mitogen-activated protein kinase-activated protein kinase 2	ISS	8262198	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	TAKRU|Ensembl=ENSTRUG00000007253|UniProtKB=H2SZQ1	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	IDA	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00627	ERK1-2	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	93028473	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00047	PDGF signaling pathway	P01154	Ras	CAEBR|Gene=CBG06092|UniProtKB=A8X0X5	Protein CBR-LET-60	ISS	12024031	PubMed	PTHR24070:SF385	GTPASE HRAS
P00057	Wnt signaling pathway	P01443	Phospholipase C	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00059	p53 pathway	G04694	p110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IDA	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=619858|UniProtKB=P70579	Metabotropic glutamate receptor 8	IDA	12488551	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00005	Angiogenesis	P00181	SHP2	DANRE|ZFIN=ZDB-GENE-030131-5911|UniProtKB=F1QZU5	Tyrosine-protein phosphatase non-receptor type	ISS	7681589	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	BOVIN|Ensembl=ENSBTAG00000007191|UniProtKB=O97919	C-C motif chemokine 5	ISS	250208	gi	PTHR12015:SF82	C-C MOTIF CHEMOKINE 5
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95809|UniProtKB=P23819	Glutamate receptor 2	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MONDO|Ensembl=ENSMODG00000013079|UniProtKB=F7FB74	Uncharacterized protein	ISS	1648176	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	TAS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DICDI|dictyBase=DDB_G0269234|UniProtKB=P07830	Major actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04398	p53 pathway feedback loops 2	P04651	Ras	CAEEL|WormBase=WBGene00002335|UniProtKB=P22981	Ras protein let-60	IDA	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00928	alpha actinin	RAT|RGD=61816|UniProtKB=Q9QXQ0	Alpha-actinin-4	IPI	2116421	PubMed	PTHR43947:SF7	ALPHA-ACTININ-4
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	MOUSE|MGI=MGI=106684|UniProtKB=Q8R090	Chromaffin granule amine transporter	ISS	11443533	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	BOVIN|Ensembl=ENSBTAG00000010837|UniProtKB=F1N3N9	Uncharacterized protein	ISS	12181435	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	XENTR|Xenbase=XB-GENE-493937|UniProtKB=Q5M8T9	Actin, alpha 2, smooth muscle, aorta	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	HUMAN|HGNC=4572|UniProtKB=P42262	Glutamate receptor 2	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00020	FAS signaling pathway	P00593	Caspase9	HUMAN|HGNC=1511|UniProtKB=P55211	Caspase-9	IGI	9390557	PubMed	PTHR10454:SF157	CASPASE-9
P05731	GABA-B receptor II signaling	P05753	Ca channel	MACMU|Ensembl=ENSMMUG00000017256|UniProtKB=F7GWW5	Uncharacterized protein	ISS	18021322	PubMed	PTHR10037:SF137	VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1G
P00004	Alzheimer disease-presenilin pathway	P00137	Tip60	MONDO|Ensembl=ENSMODG00000012142|UniProtKB=F7DHZ3	Histone acetyltransferase	ISS			PTHR10615:SF102	HISTONE ACETYLTRANSFERASE KAT7
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CHICK|Gene=CHRM4|UniProtKB=P17200	Muscarinic acetylcholine receptor M4	IDA	12181435	PubMed	PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00047	PDGF signaling pathway	P01160	IP3 receptor	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	TAS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	MOUSE|MGI=MGI=109482|UniProtKB=P97445	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	11976940	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00012	Cadherin signaling pathway	P00474	Wnt	XENTR|Xenbase=XB-GENE-485280|UniProtKB=F6X3B2	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000014751|UniProtKB=H2R8D8	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04572	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00008	Axon guidance mediated by Slit/Robo	P00355	Rho	ORNAN|Ensembl=ENSOANG00000008835|UniProtKB=F7FR08	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00018	EGF receptor signaling pathway	P00546	GAP	DICDI|dictyBase=DDB_G0274211|UniProtKB=Q8SSU4	Uncharacterized protein	ISS	19682975	gi	PTHR10194:SF81	SUBFAMILY NOT NAMED
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00054	Toll receptor signaling pathway	P01375	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02729	Ascorbate degradation	P02849	L-xylulose kinase	BACTN|EnsemblGenome=BT_4423|UniProtKB=Q89ZF4	Xylulose kinase	ISS			PTHR43095:SF5	SUBFAMILY NOT NAMED
P00010	B cell activation	P00371	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	ARATH|TAIR=AT1G10210|UniProtKB=Q39021	Mitogen-activated protein kinase 1	TAS			PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P04395	Vasopressin synthesis	P04596	Endo Peptidase	RAT|RGD=620841|UniProtKB=O70196	Prolyl endopeptidase	IC	9695945	PubMed	PTHR42881:SF2	PROLYL ENDOPEPTIDASE
P00021	FGF signaling pathway	P00648	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	PANTR|Ensembl=ENSPTRG00000007084|UniProtKB=H2Q9G5	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04398	p53 pathway feedback loops 2	P04665	AKT	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01043	AC	RAT|RGD=708450|UniProtKB=Q9Z286	Adenylate cyclase type 10	IC	11744988	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IDA	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00054	Toll receptor signaling pathway	P01358	ERK1	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00936	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01212	p38 MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00048	PI3 kinase pathway	P01185	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P06664	Gonadotropin-releasing hormone receptor pathway	G06677	Junc	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	RCA	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00053	T cell activation	P01311	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	PANTR|Ensembl=ENSPTRG00000008601|UniProtKB=H2QBY1	Arrestin, beta 2	ISS	4757780	gi	PTHR11792:SF20	BETA-ARRESTIN-2
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	RAT|RGD=3693|UniProtKB=Q01818	Chromaffin granule amine transporter	ISS	11443533	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	PANTR|Ensembl=ENSPTRG00000004222|UniProtKB=H2Q4N4	Uncharacterized protein	ISS	98180967	PubMed	PTHR10201:SF165	COLLAGENASE 3
P00019	Endothelin signaling pathway	P00583	cPLA2	CHICK|Ensembl=ENSGALG00000005065|UniProtKB=P49147	Cytosolic phospholipase A2	IGI	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00019	Endothelin signaling pathway	P00583	cPLA2	CANLF|Ensembl=ENSCAFG00000013778|UniProtKB=F6UQ33	Phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00005	Angiogenesis	P00227	PLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	IDA	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00003	Alzheimer disease-amyloid secretase pathway	P00108	ADAM10	MONDO|Ensembl=ENSMODG00000008735|UniProtKB=F6PTE7	Uncharacterized protein	ISS	12354787	PubMed	PTHR11905:SF4	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 10
P04398	p53 pathway feedback loops 2	P04665	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02785	Valine biosynthesis	P03215	Branched chain amino acid aminotransferase	HALSA|EnsemblGenome=VNG_2122G|UniProtKB=Q9HNF8	Branched-chain amino acid aminotransferase	ISS			PTHR42743:SF3	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE-LIKE PROTEIN 1-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01390	TFIIA complex	YEAST|SGD=S000005720|UniProtKB=P32773	Transcription initiation factor IIA large subunit	ISS	600519	OMIM	PTHR12694:SF8	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1
P00030	Hypoxia response via HIF activation	P00819	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04393	Ras Pathway	P04555	PDK	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	IDA	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00025	Hedgehog signaling pathway	P00682	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=107924|UniProtKB=Q64527	Protein Wnt-8a	IDA	8717036	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IC	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00021	FGF signaling pathway	P00628	JNK1-3	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00048	PI3 kinase pathway	P01203	p101	HUMAN|HGNC=30035|UniProtKB=Q8WYR1	Phosphoinositide 3-kinase regulatory subunit 5	IC	12507995	PubMed	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00030	Hypoxia response via HIF activation	P00824	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04398	p53 pathway feedback loops 2	P04663	Mdm2	DANRE|ZFIN=ZDB-GENE-990415-153|UniProtKB=O42354	E3 ubiquitin-protein ligase Mdm2	IGI	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00023	General transcription regulation	P00664	TFIIH complex	DICDI|dictyBase=DDB_G0275517|UniProtKB=Q86IB5	General transcription factor IIH subunit 3	ISS			PTHR12831:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00012	Cadherin signaling pathway	P00471	Cadherin	XENTR|Xenbase=XB-GENE-484592|UniProtKB=F7BE94	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF322	CADHERIN-6
P00047	PDGF signaling pathway	P01160	IP3 receptor	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	IC	10477300	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	BRAFL|Gene=BRAFLDRAFT_220697|UniProtKB=C3ZSF0	Putative uncharacterized protein	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	10218114	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00005	Angiogenesis	P00188	Ets	HUMAN|HGNC=3488|UniProtKB=P14921	Protein C-ets-1	IDA	15298723	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00048	PI3 kinase pathway	P01192	p110	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	DANRE|Ensembl=ENSDARG00000071640|UniProtKB=E7F359	Uncharacterized protein	ISS			PTHR43893:SF9	SUBFAMILY NOT NAMED
P02771	Pyrimidine Metabolism	P03129	Aminotransferase	CANLF|Ensembl=ENSCAFG00000019030|UniProtKB=E2R776	Uncharacterized protein	ISS	2496985	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00059	p53 pathway	P01486	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00025	Hedgehog signaling pathway	P00682	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P02759	Pyridoxal-5-phosphate biosynthesis	P03062	1-Deoxyxylulose-5-phosphate synthase	STRCO|EnsemblGenome=CAD55365|UniProtKB=Q8CJP7	1-deoxy-D-xylulose-5-phosphate synthase 2	ISS			PTHR43322:SF6	1-DEOXY-D-XYLULOSE-5-PHOSPHATE SYNTHASE
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00036	Interleukin signaling pathway	P00965	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	IC	93028473	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00005	Angiogenesis	P00238	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	3035212	PubMed	PTHR24070:SF385	GTPASE HRAS
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00018	EGF receptor signaling pathway	P00539	14-3-3	CANLF|Ensembl=ENSCAFG00000009514|UniProtKB=F1PKW7	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00012	Cadherin signaling pathway	P00474	Wnt	DROME|FlyBase=FBgn0038134|UniProtKB=Q9VFX1	Wnt inhibitor of Dorsal protein	ISS	8717036	PubMed	PTHR12027:SF98	PROTEIN WNT-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MOUSE|MGI=MGI=95823|UniProtKB=Q03391	Glutamate receptor ionotropic, NMDA 2D	IC	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00029	Huntington disease	P00799	JNK-2	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00048	PI3 kinase pathway	P01202	p85	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00036	Interleukin signaling pathway	P00965	ERK	CANLF|Ensembl=ENSCAFG00000018202|UniProtKB=E2RPJ2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	RAT|RGD=67385|UniProtKB=Q8VGC3	Voltage-dependent L-type calcium channel subunit beta-2	IC	20088160	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00006	Apoptosis signaling pathway	P00268	GCK	BOVIN|Ensembl=ENSBTAG00000014792|UniProtKB=F1N2U3	Mitogen-activated protein kinase kinase kinase kinase	ISS			PTHR24361:SF324	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 5
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEEL|WormBase=WBGene00018620|UniProtKB=O44588	Uncharacterized protein	ISS	3045562	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P00053	T cell activation	P01294	NFAT	HUMAN|HGNC=7776|UniProtKB=Q13469	Nuclear factor of activated T-cells, cytoplasmic 2	IGI	9133421	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00007	Axon guidance mediated by semaphorins	P00332	Fes	HUMAN|HGNC=3657|UniProtKB=P07332	Tyrosine-protein kinase Fes/Fps	ISS			PTHR24418:SF197	TYROSINE-PROTEIN KINASE FES/FPS
P00021	FGF signaling pathway	P00629	PP2A	SCHPO|PomBase=SPCC188.02|UniProtKB=Q10428	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta 1 isoform	ISS	10092233	PubMed	PTHR10257:SF3	PP2A-B', ISOFORM B
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00965	ERK	CANLF|Ensembl=ENSCAFG00000018202|UniProtKB=E2RPJ2	Mitogen-activated protein kinase	ISS	12912994	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P05916	Opioid prodynorphin pathway	P06002	G-protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT1G01560|UniProtKB=Q9LMM5	Mitogen-activated protein kinase 11	IDA	10514528	PubMed	PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P06587	Nicotine pharmacodynamics pathway	P06599	EPB41L1	BOVIN|Ensembl=ENSBTAG00000001640|UniProtKB=F1N611	Uncharacterized protein	ISS	12181426	PubMed	PTHR23280:SF24	BAND 4.1-LIKE PROTEIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P06212	DPP-SCW signaling pathway	P06268	SHN	DROME|Gene=Dmel_CG7734|UniProtKB=A0A0B4KFC0	Schnurri, isoform F	IDA	17008448	PubMed	PTHR23233:SF61	SCHNURRI, ISOFORM F
P00029	Huntington disease	P00796	Kainate receptor	HUMAN|HGNC=4580|UniProtKB=Q13002	Glutamate receptor ionotropic, kainate 2	IDA	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00056	VEGF signaling pathway	P01419	Ets	BOVIN|Ensembl=ENSBTAG00000002341|UniProtKB=A5PJG9	ETS1 protein	ISS	15298723	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P05734	Synaptic vesicle trafficking	P05770	Munc18	XENTR|Xenbase=XB-GENE-945143|UniProtKB=F7ED11	Uncharacterized protein (Fragment)	ISS	8108429	PubMed	PTHR11679:SF35	SYNTAXIN-BINDING PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	SCLS1|EnsemblGenome=SS1G_03482|UniProtKB=A7EDU2	Guanine nucleotide-binding protein beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00052	TGF-beta signaling pathway	P01288	FKBP12	TAKRU|Ensembl=ENSTRUG00000004717|UniProtKB=H2SFL7	Peptidyl-prolyl cis-trans isomerase	ISS			PTHR10516:SF341	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	CANLF|Ensembl=ENSCAFG00000016388|UniProtKB=F6X9W7	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P00051	TCA cycle	P01267	Citrate Synthase	DROME|FlyBase=FBgn0037988|UniProtKB=Q95TZ4	Citrate synthase	RCA			PTHR11739:SF8	CITRATE SYNTHASE, MITOCHONDRIAL
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000013022|UniProtKB=H2QJL0	Uncharacterized protein	ISS			PTHR24247:SF31	5-HYDROXYTRYPTAMINE RECEPTOR 2B
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00052	TGF-beta signaling pathway	P01275	P38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	TAS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	HUMAN|HGNC=877|UniProtKB=P49419	Alpha-aminoadipic semialdehyde dehydrogenase	IC			PTHR43521:SF1	ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00273	p53	CANLF|Gene=TP53|UniProtKB=Q29537	Cellular tumor antigen p53	ISS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00021	FGF signaling pathway	P00626	Spry	PANTR|Ensembl=ENSPTRG00000017360|UniProtKB=H2QRP3	Uncharacterized protein	ISS	10330503	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IC	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00005	Angiogenesis	P00244	MAPKAPK2/3	CHICK|Ensembl=ENSGALG00000000883|UniProtKB=F1NCY7	Uncharacterized protein	ISS			PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000025373|UniProtKB=F6ZZG9	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00057	Wnt signaling pathway	P01443	Phospholipase C	DROME|FlyBase=FBgn0004611|UniProtKB=P25455	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II	IDA	12860966	PubMed	PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00029	Huntington disease	P00778	NMDA receptor	CANLF|Gene=GRIN1|UniProtKB=Q5R1P0	Glutamate receptor ionotropic, NMDA 1	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	RAT|RGD=1304988|UniProtKB=A0A0G2K6Q8	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00057	Wnt signaling pathway	P01438	PP2A	MACMU|Ensembl=ENSMMUG00000004873|UniProtKB=F7ANY9	Uncharacterized protein	ISS	96161994	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00010	B cell activation	P00371	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06587	Nicotine pharmacodynamics pathway	P06605	KCNK3/9	BOVIN|Ensembl=ENSBTAG00000018193|UniProtKB=E1BHX8	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000002349|UniProtKB=P61267	Syntaxin-1B	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00005	Angiogenesis	P00255	Notch	BOVIN|Ensembl=ENSBTAG00000007909|UniProtKB=F1MPE9	Uncharacterized protein	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00760	Gtalpha	HUMAN|HGNC=4393|UniProtKB=P11488	Guanine nucleotide-binding protein G(t) subunit alpha-1	IDA	6264430	PubMed	PTHR10218:SF67	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-1
P00029	Huntington disease	P00790	beta-Tubulin	PHYPA|Gene=PHYPADRAFT_223215|UniProtKB=Q6TYR8	Beta-tubulin 6	ISS	12932731	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	CANLF|Ensembl=ENSCAFG00000000332|UniProtKB=F1P8E3	Uncharacterized protein	ISS	11431030	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	1170702	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00973	PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	HUMAN|HGNC=4593|UniProtKB=Q13255	Metabotropic glutamate receptor 1	ISS	12351712	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	PANTR|Gene=CHRM3|UniProtKB=Q9N2A4	Muscarinic acetylcholine receptor M3	ISS	11166329	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00045	Notch signaling pathway	P01116	Delta	RAT|RGD=70953|UniProtKB=O88671	Delta-like protein 3	ISS	12175503	PubMed	PTHR24044:SF308	DELTA-LIKE PROTEIN 3
P00057	Wnt signaling pathway	P01440	Cadherin	BOVIN|Gene=CDH2|UniProtKB=P19534	Cadherin-2 (Fragment)	IDA	8120095	PubMed	PTHR24027:SF79	CADHERIN-2
P00037	Ionotropic glutamate receptor pathway	P01018	Glu1	MONDO|Ensembl=ENSMODG00000008900|UniProtKB=F7B4C1	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00029	Huntington disease	P00780	Microtubule	ORNAN|Ensembl=ENSOANG00000003049|UniProtKB=F7B0P2	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00053	T cell activation	P01307	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	RAT|RGD=69319|UniProtKB=P54313	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00053	T cell activation	P01324	rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_125401|UniProtKB=C3ZTX6	Putative uncharacterized protein	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00056	VEGF signaling pathway	P01417	Raf	MOUSE|MGI=MGI=88190|UniProtKB=P28028	Serine/threonine-protein kinase B-raf	ISS	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00034	Integrin signalling pathway	P00925	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00010	B cell activation	P00367	NFAT	RAT|RGD=1310749|UniProtKB=D3Z9H7	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	ISS	9133421	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00029	Huntington disease	P00778	NMDA receptor	RAT|RGD=2738|UniProtKB=Q00960	Glutamate receptor ionotropic, NMDA 2B	IDA	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	ARATH|TAIR=AT1G55520|UniProtKB=P28148	TATA-box-binding protein 2	ISS	600075	OMIM	PTHR10126:SF36	TATA-BOX-BINDING PROTEIN 1-RELATED
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	RCA	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P05918	p38 MAPK pathway	P06021	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	IDA	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=69424|UniProtKB=Q99P84	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	7822322	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P05918	p38 MAPK pathway	P06031	p38alpha	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	RCA	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00030	Hypoxia response via HIF activation	P00823	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	MACMU|Ensembl=ENSMMUG00000018571|UniProtKB=F6YLU2	Uncharacterized protein	ISS	608972	OMIM	PTHR22952:SF24	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TRIVA|Gene=TVAG_337240|UniProtKB=P90623	Actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00046	Oxidative stress response	P01131	MKP5	HUMAN|HGNC=17007|UniProtKB=O95147	Dual specificity protein phosphatase 14	ISS			PTHR10159:SF338	DUAL SPECIFICITY PROTEIN PHOSPHATASE 14
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00757	beta-arrestin	MOUSE|MGI=MGI=98227|UniProtKB=P20443	S-arrestin	IDA	11742073	PubMed	PTHR11792:SF15	S-ARRESTIN
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=69308|UniProtKB=Q63433	Serine/threonine-protein kinase N1	TAS	10644715	PubMed	PTHR24356:SF246	SERINE/THREONINE-PROTEIN KINASE N1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	DROME|FlyBase=FBgn0019985|UniProtKB=P91685	Metabotropic glutamate receptor	IDA	12488551	PubMed	PTHR24060:SF137	METABOTROPIC GLUTAMATE RECEPTOR
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	HUMAN|HGNC=1950|UniProtKB=P11229	Muscarinic acetylcholine receptor M1	ISS	10069496	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	IC	91298951	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00625	MKK3,6	CHICK|Ensembl=ENSGALG00000004735|UniProtKB=F1NHE1	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00029	Huntington disease	P00786	ARF	MOUSE|MGI=MGI=99432|UniProtKB=P61205	ADP-ribosylation factor 3	ISS	12932731	PubMed	PTHR11711:SF294	ADP-RIBOSYLATION FACTOR 3
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	TAS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00046	Oxidative stress response	P01129	JNK1/2	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	TAS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00009	Axon guidance mediated by netrin	P00364	cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00029	Huntington disease	P00786	ARF	MOUSE|MGI=MGI=99433|UniProtKB=P61750	ADP-ribosylation factor 4	IPI	12932731	PubMed	PTHR11711:SF110	ADP-RIBOSYLATION FACTOR 4
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00114	actin	XENTR|Xenbase=XB-GENE-490883|UniProtKB=Q6NVA9	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00641	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	CANLF|Ensembl=ENSCAFG00000024151|UniProtKB=E2R795	Tyrosine-protein kinase receptor	ISS	10226785	PubMed	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00034	Integrin signalling pathway	P00924	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00964	p90RSK	MACMU|Ensembl=ENSMMUG00000002134|UniProtKB=F6UNV6	Ribosomal protein S6 kinase	ISS	10558991	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	TAKRU|Ensembl=ENSTRUG00000014739|UniProtKB=H2UL58	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00059	p53 pathway	P04609	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	TAKRU|Ensembl=ENSTRUG00000003442|UniProtKB=H2S6Q5	Uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF197	CALMODULIN-LIKE PROTEIN 3
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00018	EGF receptor signaling pathway	P00539	14-3-3	HUMAN|HGNC=12852|UniProtKB=P61981	14-3-3 protein gamma	ISS	10407019	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	BOVIN|Ensembl=ENSBTAG00000008967|UniProtKB=P61223	Ras-related protein Rap-1b	ISS	8576107	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00006	Apoptosis signaling pathway	P00310	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	IDA	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00736	CalDAG-GEF	BOVIN|Ensembl=ENSBTAG00000021872|UniProtKB=E1BG59	Uncharacterized protein	ISS	10835426	PubMed	PTHR23113:SF174	RAS GUANYL-RELEASING PROTEIN 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PHYIT|EnsemblGenome=PITG_06376|UniProtKB=D0N4Q3	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta, putative	IC	12081467	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00047	PDGF signaling pathway	P01161	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	3449797	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	BACSU|EnsemblGenome=BSU11240|UniProtKB=P18185	Carbamoyl-phosphate synthase arginine-specific large chain	ISS			PTHR11405:SF5	CAD PROTEIN
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	TAS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01159	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00005	Angiogenesis	P00203	Erk	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02734	Chorismate biosynthesis	P02870	3-Phosphoshikimate-1-carboxyvinyl transferase	STRCO|EnsemblGenome=CAB71266|UniProtKB=Q9L213	3-phosphoshikimate 1-carboxyvinyltransferase 2	ISS			PTHR21090:SF5	PENTAFUNCTIONAL AROM POLYPEPTIDE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	STRPU|EnsemblGenome=SPU_007424|UniProtKB=W4XVG8	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF155	TUBULIN BETA-2 CHAIN
P00048	PI3 kinase pathway	P01188	Gbetagamma	SCLS1|EnsemblGenome=SS1G_03482|UniProtKB=A7EDU2	Guanine nucleotide-binding protein beta subunit	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00059	p53 pathway	G01571	FAS	MOUSE|MGI=MGI=95484|UniProtKB=P25446	Tumor necrosis factor receptor superfamily member 6	IGI	1371136	PubMed	PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P00010	B cell activation	P00380	fos	BOVIN|Ensembl=ENSBTAG00000004322|UniProtKB=O77628	Proto-oncogene c-Fos	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P02753	Methionine biosynthesis	P03023	Homoserine succinyltransferase	BACTN|EnsemblGenome=BT_2413|UniProtKB=Q8A531	Homoserine O-succinyltransferase	ISS			PTHR20919:SF0	HOMOSERINE O-SUCCINYLTRANSFERASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00057	Wnt signaling pathway	P01472	Histone deacetylase	ARATH|TAIR=AT5G35600|UniProtKB=Q9FH09	Histone deacetylase 7	IDA	10485845	PubMed	PTHR10625:SF144	HISTONE DEACETYLASE 6-RELATED
P00010	B cell activation	P00381	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	ORYSJ|EnsemblGenome=OS03G0794500|UniProtKB=Q852M0	Glutamate dehydrogenase	ISS			PTHR11606:SF18	GLUTAMATE DEHYDROGENASE 1-RELATED
P00029	Huntington disease	P00790	beta-Tubulin	MACMU|Ensembl=ENSMMUG00000030028|UniProtKB=F7H0X2	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P02743	Formyltetrahydroformate biosynthesis	P02953	Cobalamin dependent homocysteine transmethylase	THEMA|EnsemblGenome=TM_0268|UniProtKB=Q9WYA5	5-methyltetrahydrofolate S-homocysteine methyltransferase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346347|UniProtKB=Q9WVS8	Mitogen-activated protein kinase 7	IDA	15085193	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01444	Wnt	CHICK|Ensembl=ENSGALG00000005410|UniProtKB=Q9YGX6	Protein Wnt	IDA	8717036	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02734	Chorismate biosynthesis	P02869	3-Dehydroquinate dehydratase	GLOVI|EnsemblGenome=BAC90383|UniProtKB=Q7NHU3	3-dehydroquinate dehydratase	ISS			PTHR21272:SF3	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000029720|UniProtKB=H2RIK3	Uncharacterized protein	ISS	11781138	PubMed	PTHR24248:SF24	ALPHA-2A ADRENERGIC RECEPTOR
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00227	PLA2	RAT|RGD=67366|UniProtKB=P50393	Cytosolic phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	MOUSE|MGI=MGI=1914939|UniProtKB=Q80VQ0	Aldehyde dehydrogenase family 3 member B1	IC			PTHR43570:SF2	ALDEHYDE DEHYDROGENASE FAMILY 3 MEMBER B1
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00019	Endothelin signaling pathway	P00566	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-040718-134|UniProtKB=Q6DH55	Guanine nucleotide binding protein (G protein), beta polypeptide 3, like	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00060	Ubiquitin proteasome pathway	P01491	E2	HUMAN|HGNC=17895|UniProtKB=Q16763	Ubiquitin-conjugating enzyme E2 S	ISS			PTHR44066:SF1	UBIQUITIN-CONJUGATING ENZYME E2 S
P00048	PI3 kinase pathway	P01193	IRS	CANLF|Ensembl=ENSCAFG00000010397|UniProtKB=E2RDB5	Uncharacterized protein	ISS	1311924	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00475	Frizzled	PANTR|Ensembl=ENSPTRG00000028511|UniProtKB=H2R570	Uncharacterized protein	ISS	12549854	PubMed	PTHR11309:SF81	FRIZZLED-1
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000005917|UniProtKB=F6QM53	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P05912	Dopamine receptor mediated signaling pathway	P05960	VAT2	MACMU|Ensembl=ENSMMUG00000014817|UniProtKB=F6VXD8	Uncharacterized protein	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00023	General transcription regulation	P00660	RNA Polymerase II	TAKRU|Ensembl=ENSTRUG00000018238|UniProtKB=H2VBT9	Uncharacterized protein	ISS			PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	RAT|RGD=61866|UniProtKB=P30839	Fatty aldehyde dehydrogenase	IC	14724059	PubMed	PTHR43570:SF9	FATTY ALDEHYDE DEHYDROGENASE
P00049	Parkinson disease	P01215	Syntaxin	RAT|RGD=619747|UniProtKB=O70257	Syntaxin-7	IPI	10321247	PubMed	PTHR19957:SF90	SYNTAXIN-7
P02741	Flavin biosynthesis	P02934	Riboflavin kinase	STRCO|Gene=CAB37472|UniProtKB=Q9Z530	Riboflavin biosynthesis protein	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P06959	CCKR signaling map	P07228	MAPK1/3	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	RCA	12706116	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01332	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01339	TLR4	PANTR|Ensembl=ENSPTRG00000021299|UniProtKB=H2QXS5	Toll-like receptor 4	ISS			PTHR44568:SF1	TOLL-LIKE RECEPTOR 4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MACMU|Ensembl=ENSMMUG00000011231|UniProtKB=F6WXV4	Uncharacterized protein	ISS			PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00054	Toll receptor signaling pathway	P01355	AP1	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CHICK|Ensembl=ENSGALG00000017238|UniProtKB=F1NWG3	Uncharacterized protein	IDA	8314195	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00006	Apoptosis signaling pathway	P00313	IKK	RAT|RGD=621375|UniProtKB=Q9QY78	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IGI	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00052	TGF-beta signaling pathway	P01286	TGFbeta	DROME|FlyBase=FBgn0026199|UniProtKB=Q9V4F4	LD29161p	ISS	16098524	PubMed	PTHR11848:SF176	LD29161P
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00010	B cell activation	P00367	NFAT	MACMU|Ensembl=ENSMMUG00000003370|UniProtKB=F7E8G2	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00010	B cell activation	P00373	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04395	Vasopressin synthesis	P04597	Signal Peptide	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00004	Alzheimer disease-presenilin pathway	P00148	Erb-B4 N-terminal fragment	ORNAN|Ensembl=ENSOANG00000007021|UniProtKB=F7GAV2	Receptor protein-tyrosine kinase	ISS	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00046	Oxidative stress response	P01135	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00048	PI3 kinase pathway	P01185	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00012	Cadherin signaling pathway	P00474	Wnt	RAT|RGD=1305018|UniProtKB=D3ZF63	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P00036	Interleukin signaling pathway	P00965	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00024	Glycolysis	P00679	Aldolase	BOVIN|Ensembl=ENSBTAG00000012927|UniProtKB=A6QLL8	Fructose-bisphosphate aldolase	ISS	3391172	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P04398	p53 pathway feedback loops 2	P04664	cyclin E	DANRE|ZFIN=ZDB-GENE-980526-168|UniProtKB=P47794	G1/S-specific cyclin-E1	NAS	12628165	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00034	Integrin signalling pathway	P00920	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	PANTR|Ensembl=ENSPTRG00000018427|UniProtKB=H2RCY2	Mitogen-activated protein kinase kinase kinase 7	ISS	10683140	PubMed	PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00012	Cadherin signaling pathway	P00467	alpha-catenin	TAKRU|Ensembl=ENSTRUG00000002863|UniProtKB=H2S2N9	Uncharacterized protein	ISS	9362521	PubMed	PTHR18914:SF29	CATENIN ALPHA-2
P00012	Cadherin signaling pathway	P00462	Casein kinase II	PANTR|Ensembl=ENSPTRG00000017974|UniProtKB=H2QSN4	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00049	Parkinson disease	P01230	Src kinase	TAKRU|Ensembl=ENSTRUG00000004669|UniProtKB=H2SFA3	Tyrosine-protein kinase	IDA	11078745	PubMed	PTHR24418:SF181	TYROSINE-PROTEIN KINASE BLK
P00029	Huntington disease	G01531	BDNF	MOUSE|MGI=MGI=88145|UniProtKB=P21237	Brain-derived neurotrophic factor	ISS	11724916	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	DICDI|dictyBase=DDB_G0279911|UniProtKB=P34093	Nucleoside diphosphate kinase, mitochondrial	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00004	Alzheimer disease-presenilin pathway	P00178	BACE-1 pro-domain	PANTR|Ensembl=ENSPTRG00000013924|UniProtKB=H2R1L7	Beta-site APP-cleaving enzyme 2	ISS			PTHR13683:SF262	BETA-SECRETASE 2
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00020	FAS signaling pathway	P00610	MKK4	PANTR|Ensembl=ENSPTRG00000008783|UniProtKB=H2QCA7	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00053	T cell activation	P01331	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00018	EGF receptor signaling pathway	P00560	Raf-1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04397	p53 pathway by glucose deprivation	P04641	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-7595|UniProtKB=Q6PBR4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	HUMAN|HGNC=1401|UniProtKB=Q02641	Voltage-dependent L-type calcium channel subunit beta-1	IC	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DROME|FlyBase=FBgn0000489|UniProtKB=P16912	Protein kinase DC2	IC	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00029	Huntington disease	P00786	ARF	RAT|RGD=621278|UniProtKB=P84083	ADP-ribosylation factor 5	ISS	12932731	PubMed	PTHR11711:SF308	ADP-RIBOSYLATION FACTOR 5
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00012	Cadherin signaling pathway	P00471	Cadherin	SYNY3|Gene=BAA17114|UniProtKB=P73089	Fat protein	ISS	8120095	PubMed	PTHR24026:SF70	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01438	PP2A	HUMAN|HGNC=9311|UniProtKB=Q13362	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	IDA	8576224	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	MACMU|Ensembl=ENSMMUG00000016428|UniProtKB=F7GU00	Metabotropic glutamate receptor 1 isoform alpha	ISS	12351712	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000011466|UniProtKB=F7B2R8	Uncharacterized protein	ISS	2106672	PubMed	PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	IC	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01161	Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00048	PI3 kinase pathway	P01179	PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01332	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01206	14-3-3	XENTR|Xenbase=XB-GENE-970616|UniProtKB=Q6P4Z5	14-3-3 protein zeta	ISS	12865427	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00023	General transcription regulation	P00660	RNA Polymerase II	BOVIN|Ensembl=ENSBTAG00000040199|UniProtKB=F2Z4H3	Uncharacterized protein	ISS	606023	OMIM	PTHR10917:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3
P00010	B cell activation	P00381	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00059	p53 pathway	P04623	CBP	CAEEL|WormBase=WBGene00000366|UniProtKB=P34545	Protein cbp-1	ISS	10769018	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00010	B cell activation	P00373	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00811	Arp2/3 complex	MOUSE|MGI=MGI=1915021|UniProtKB=Q9CPW4	Actin-related protein 2/3 complex subunit 5	ISS	10322212	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00010	B cell activation	P00379	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IGI	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00053	T cell activation	P01305	Calmodulin	MONDO|Ensembl=ENSMODG00000025146|UniProtKB=F7CLC0	Uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF311	CALMODULIN
P00006	Apoptosis signaling pathway	P00269	MAPK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	ISS	12787066	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01233	Elk-1	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	11151091	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CAEEL|WormBase=WBGene00001187|UniProtKB=Q8MQA1	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00005	Angiogenesis	P00219	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00021	FGF signaling pathway	P00623	FGF	HUMAN|HGNC=3668|UniProtKB=P61328	Fibroblast growth factor 12	ISS	9232594	PubMed	PTHR11486:SF17	FIBROBLAST GROWTH FACTOR 12
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	IDA	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MONDO|Ensembl=ENSMODG00000018204|UniProtKB=F6PGX6	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P02746	Heme biosynthesis	P02975	Uroporphyrinogen decarboxylase	RAT|RGD=3946|UniProtKB=P32362	Uroporphyrinogen decarboxylase (Fragment)	ISS			PTHR21091:SF2	UROPORPHYRINOGEN DECARBOXYLASE
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	ARATH|TAIR=AT2G31300|UniProtKB=Q9SJW6	Actin-related protein 2/3 complex subunit 1B	ISS	12932731	PubMed	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	MOUSE|MGI=MGI=1930182|UniProtKB=Q9WV85	Nucleoside diphosphate kinase 3	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01076	CAT	CAEEL|WormBase=WBGene00019644|UniProtKB=O44619	Carnitine Palmitoyl Transferase	ISS			PTHR22589:SF54	CARNITINE PALMITOYL TRANSFERASE
P00029	Huntington disease	P00774	Dynein complex	MOUSE|MGI=MGI=3040680|UniProtKB=Q80ZS7	MCG49550	ISS	9454836	PubMed	PTHR11886:SF52	DYNEIN LIGHT CHAIN 1, CYTOPLASMIC
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000040439|UniProtKB=F6Q2H9	Uncharacterized protein	ISS	12181435	PubMed	PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P00047	PDGF signaling pathway	P01169	Vav	HUMAN|HGNC=12657|UniProtKB=P15498	Proto-oncogene vav	ISS	10661401	PubMed	PTHR22826:SF112	PROTO-ONCOGENE VAV
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00052	TGF-beta signaling pathway	P01286	TGFbeta	RAT|RGD=621194|UniProtKB=Q9WUK5	Inhibin beta C chain	TAS	9759503	PubMed	PTHR11848:SF130	INHIBIN BETA C CHAIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04393	Ras Pathway	P04542	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	CANLF|Ensembl=ENSCAFG00000031497|UniProtKB=J9P401	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF143	BONE MORPHOGENETIC PROTEIN 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02743	Formyltetrahydroformate biosynthesis	P02954	Thymidylate synthase	RAT|RGD=3921|UniProtKB=P45352	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=69424|UniProtKB=Q99P84	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	15611108	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P02775	Salvage pyrimidine ribonucleotides	P03156	CDP kinase	ARATH|TAIR=AT1G55820|UniProtKB=A4FVR1	GBF-interacting protein 1-like	ISS			PTHR12758:SF30	GBF-INTERACTING PROTEIN 1-LIKE
P00049	Parkinson disease	P01211	ERK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	IDA	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=88399|UniProtKB=P32211	Muscarinic acetylcholine receptor M4	IDA	12181435	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00056	VEGF signaling pathway	P01411	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04395	Vasopressin synthesis	P04599	Amidating Enzyme	BOVIN|Gene=PAM|UniProtKB=P10731	Peptidyl-glycine alpha-amidating monooxygenase	IC	3153462	PubMed	PTHR10680:SF14	PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01429	Axin	PANTR|Ensembl=ENSPTRG00000009554|UniProtKB=H2QDP9	Uncharacterized protein	ISS	9554852	PubMed	PTHR10845:SF103	AXIN-2
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00010	B cell activation	P00373	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	ORNAN|Ensembl=ENSOANG00000004058|UniProtKB=F6TYP9	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00009	Axon guidance mediated by netrin	P00359	NFAT	BOVIN|Ensembl=ENSBTAG00000004368|UniProtKB=F1MSU2	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00021	FGF signaling pathway	P00634	MEKK1-5	RAT|RGD=620967|UniProtKB=F1M9D0	Protein Map3k2	ISS	8621389	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	TAS	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00018	EGF receptor signaling pathway	P00547	PP2A	TAKRU|Ensembl=ENSTRUG00000003840|UniProtKB=H2S9H8	Uncharacterized protein	ISS	8703017	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00048	PI3 kinase pathway	P01188	Gbetagamma	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P05915	Opioid proenkephalin pathway	P05994	G-protein	DICDI|dictyBase=DDB_G0277143|UniProtKB=P36408	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00036	Interleukin signaling pathway	P00990	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	DROME|FlyBase=FBgn0015278|UniProtKB=Q7K3H0	LD28067p	ISS			PTHR10048:SF64	LD28067P
P00018	EGF receptor signaling pathway	P00561	STAT	MONDO|Ensembl=ENSMODG00000014816|UniProtKB=F7CHH2	Signal transducer and activator of transcription	ISS	95236292	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00018	EGF receptor signaling pathway	P00554	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	95096035	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00018	EGF receptor signaling pathway	P00557	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	BOVIN|Ensembl=ENSBTAG00000017411|UniProtKB=A4IFD0	Adenylate kinase isoenzyme 5	ISS			PTHR23359:SF79	ADENYLATE KINASE ISOENZYME 5
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	CAEBR|Gene=CBG_05938|UniProtKB=H8WGV2	Protein CBR-ITR-1, isoform a	ISS	9065779	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00045	Notch signaling pathway	P01104	Serrate	DANRE|ZFIN=ZDB-GENE-011128-3|UniProtKB=Q5TZK8	Delta-like protein	IGI	9806913	PubMed	PTHR44097:SF1	PROTEIN JAGGED-2
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	XENTR|Xenbase=XB-GENE-854877|UniProtKB=F7C949	Presenilin	ISS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	12805548	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00021	FGF signaling pathway	P00647	SHP2	CHICK|Ensembl=ENSGALG00000004821|UniProtKB=Q90687	Tyrosine-protein phosphatase non-receptor type 11	ISS	14534538	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00012	Cadherin signaling pathway	P00475	Frizzled	ANOGA|Gene=AgaP_AGAP011382|UniProtKB=Q7Q2X0	AGAP011382-PA (Fragment)	ISS	11212302	PubMed	PTHR11309:SF47	FRIZZLED
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	BOVIN|Ensembl=ENSBTAG00000016187|UniProtKB=F1N213	Uncharacterized protein	ISS			PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CHICK|Ensembl=ENSGALG00000006576|UniProtKB=E1BUE5	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00021	FGF signaling pathway	P00625	MKK3,6	MONDO|Ensembl=ENSMODG00000001404|UniProtKB=F7BD74	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00018	EGF receptor signaling pathway	P00559	MEK1-2	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IGI	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-7596|UniProtKB=Q6PBN9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF26	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT GAMMA-T1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00010	B cell activation	P00379	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00019	Endothelin signaling pathway	P00591	PLCbeta	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IGI	9860142	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01148	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	4504111	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P05731	GABA-B receptor II signaling	P05754	Ggamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P02783	Tryptophan biosynthesis	P03208	Tryptophan synthase B	PYRAE|EnsemblGenome=PAE2462|UniProtKB=Q8ZV44	Tryptophan synthase beta chain	ISS			PTHR43565:SF1	TRYPTOPHAN SYNTHASE BETA CHAIN
P00053	T cell activation	P01294	NFAT	MOUSE|MGI=MGI=103296|UniProtKB=P97305	Nuclear factor of activated T-cells, cytoplasmic 3	IGI	12015605	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00029	Huntington disease	P00810	GAPDH	DANRE|ZFIN=ZDB-GENE-030115-1|UniProtKB=Q5XJ10	Glyceraldehyde-3-phosphate dehydrogenase	ISS	8612237	PubMed	PTHR10836:SF51	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00046	Oxidative stress response	P01137	MNK1/2	HUMAN|HGNC=7111|UniProtKB=Q9HBH9	MAP kinase-interacting serine/threonine-protein kinase 2	IDA	9155017	PubMed	PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CAEEL|WormBase=WBGene00010545|UniProtKB=G5EBG3	CBP/p300 homolog	TAS	8413673	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00021	FGF signaling pathway	P00645	Rac	DICDI|dictyBase=DDB_G0293526|UniProtKB=P34149	Rho-related protein racC	ISS	8649368	PubMed	PTHR24072:SF117	RHO-RELATED PROTEIN RACC
P04393	Ras Pathway	P04569	Cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00009	Axon guidance mediated by netrin	P00356	UNC-5	MACMU|Ensembl=ENSMMUG00000005998|UniProtKB=F6UDV7	Uncharacterized protein	ISS			PTHR12582:SF6	NETRIN RECEPTOR UNC5B
P00018	EGF receptor signaling pathway	P00558	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00936	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01284	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00045	Notch signaling pathway	P01120	NIcs	MOUSE|MGI=MGI=97364|UniProtKB=O35516	Neurogenic locus notch homolog protein 2	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	PANTR|Ensembl=ENSPTRG00000023062|UniProtKB=H2R2U1	Catenin (Cadherin-associated protein), beta 1, 88kDa	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00047	PDGF signaling pathway	P01161	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	STRCO|EnsemblGenome=CAB76898|UniProtKB=Q9L0Y3	S-adenosylmethionine synthase	ISS			PTHR11964:SF1	S-ADENOSYLMETHIONINE SYNTHASE
P00021	FGF signaling pathway	P00647	SHP2	MONDO|Ensembl=ENSMODG00000003120|UniProtKB=F6WVD2	Tyrosine-protein phosphatase non-receptor type	ISS	7681589	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00060	Ubiquitin proteasome pathway	P01491	E2	PHYPA|Gene=PHYPADRAFT_170260|UniProtKB=A9TIG8	Predicted protein	ISS			PTHR43902:SF2	UBIQUITIN-CONJUGATING ENZYME E2 N
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	CHICK|Ensembl=ENSGALG00000016308|UniProtKB=P01109	Myc proto-oncogene protein	IEP	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00053	T cell activation	P01312	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MOUSE|MGI=MGI=95821|UniProtKB=Q01097	Glutamate receptor ionotropic, NMDA 2B	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00048	PI3 kinase pathway	P01182	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P02738	De novo purine biosynthesis	P02902	ADP reductase	HUMAN|HGNC=17296|UniProtKB=Q7LG56	Ribonucleoside-diphosphate reductase subunit M2 B	ISS			PTHR23409:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 B
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MONDO|Ensembl=ENSMODG00000006737|UniProtKB=F7CDC6	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF90	FRIZZLED-8
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00053	T cell activation	P01303	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8316835	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00049	Parkinson disease	P01236	Casein kinase II	DROME|FlyBase=FBgn0026136|UniProtKB=O96863	Casein kinase II subunit beta'	IDA	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00021	FGF signaling pathway	P00642	MEK1-2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05730	Endogenous cannabinoid signaling	P05746	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CANLF|Ensembl=ENSCAFG00000018560|UniProtKB=F1PJ01	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF335	MYOSIN-11
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00019	Endothelin signaling pathway	P00572	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	IC	94313981	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	RAT|RGD=1561992|UniProtKB=E9PU77	Protein Sytl3	ISS			PTHR10024:SF222	SYNAPTOTAGMIN-LIKE PROTEIN 3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05918	p38 MAPK pathway	P06034	MKK4	BOVIN|Ensembl=ENSBTAG00000012103|UniProtKB=A5PJP8	MAP2K4 protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00022	General transcription by RNA polymerase I	P00657	TBP	ENTHI|Gene=EHI_020610|UniProtKB=P52653	TATA-box-binding protein 1	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P04393	Ras Pathway	P04542	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00047	PDGF signaling pathway	P01168	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	BOVIN|Gene=MYH7|UniProtKB=Q9BE39	Myosin-7	IEP	10938134	PubMed	PTHR13140:SF344	MYOSIN-7
P02747	Histidine biosynthesis	P02987	ATP phosphoribosyl transferase	BACTN|EnsemblGenome=BT_0200|UniProtKB=Q8ABB0	ATP phosphoribosyltransferase	ISS			PTHR21403:SF4	ATP PHOSPHORIBOSYLTRANSFERASE
P00036	Interleukin signaling pathway	P00981	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	TAS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	IDA	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT1G01560|UniProtKB=Q9LMM5	Mitogen-activated protein kinase 11	ISS	10514528	PubMed	PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P00036	Interleukin signaling pathway	P00990	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00058	mRNA splicing	P01479	U1	RAT|RGD=1307416|UniProtKB=Q5U214	Protein Snrpa	RCA			PTHR10501:SF31	U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	IC	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANAL|CGD=CAL0003231|UniProtKB=Q5ANK2	Protein kinase C	TAS	8813761	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00047	PDGF signaling pathway	P01175	Shc	BOVIN|Ensembl=ENSBTAG00000019838|UniProtKB=Q0IIE2	SHC-transforming protein 1	ISS	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000022319|UniProtKB=F6XDA0	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00040	Metabotropic glutamate receptor group II pathway	P01052	AC	MOUSE|MGI=MGI=2660854|UniProtKB=Q8C0T9	Adenylate cyclase type 10	ISS	9874775	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P00017	DNA replication	P00536	DNA Topisomerase	SCHPO|PomBase=SPBC1A4.03c|UniProtKB=P08096	DNA topoisomerase 2	ISS			PTHR10169:SF38	DNA TOPOISOMERASE 2
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	DROME|Gene=Dmel_CG7904|UniProtKB=A0A0B4KG59	Serine/threonine-protein kinase receptor	TAS	http://flybase.org/reports/FBgn0003169.html	Website	PTHR23255:SF70	SERINE/THREONINE-PROTEIN KINASE RECEPTOR
P00021	FGF signaling pathway	P00641	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00021	FGF signaling pathway	P00624	14-3-3	NEUCR|EnsemblGenome=EFNCRG00000002359|UniProtKB=Q7RVK6	14-3-3 family protein 7	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	PANTR|Ensembl=ENSPTRG00000001749|UniProtKB=H2Q0Q4	Uncharacterized protein	ISS	14624853	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00057	Wnt signaling pathway	P01439	C-terminal Binding Protein	CHICK|Ensembl=ENSGALG00000015718|UniProtKB=Q5ZIZ6	Uncharacterized protein	ISS	10375506	PubMed	PTHR10996:SF128	C-TERMINAL-BINDING PROTEIN 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00009	Axon guidance mediated by netrin	P00359	NFAT	PANTR|Ensembl=ENSPTRG00000008260|UniProtKB=H2QBD7	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	ISS	12787506	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00056	VEGF signaling pathway	P01408	Akt/PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00034	Integrin signalling pathway	P00925	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02752	Mannose metabolism	P03017	Mannose 6-P isomerase	CRYNJ|EnsemblGenome=CNI02370|UniProtKB=Q9HFU4	Mannose-6-phosphate isomerase	ISS	11359567	PubMed	PTHR10309:SF0	MANNOSE-6-PHOSPHATE ISOMERASE
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	NAS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00011	Blood coagulation	P00448	vWF	MACMU|Ensembl=ENSMMUG00000022893|UniProtKB=F6WF14	Uncharacterized protein	ISS	11583304	PubMed	PTHR11339:SF361	VON WILLEBRAND FACTOR-RELATED
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MOUSE|MGI=MGI=1913316|UniProtKB=P61953	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	ISS	2122451	PubMed	PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P02721	ATP synthesis	P02791	F1 alpha	ARATH|TAIR=ATMG01190|UniProtKB=P92549	ATP synthase subunit alpha, mitochondrial	TAS	1423717	PubMed	PTHR43089:SF2	ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	PANTR|Ensembl=ENSPTRG00000006342|UniProtKB=H2Q8A8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IGI	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	HUMAN|HGNC=3086|UniProtKB=O14641	Segment polarity protein dishevelled homolog DVL-2	TAS	10409711	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	PSEAE|EnsemblGenome=PA0393|UniProtKB=P22008	Pyrroline-5-carboxylate reductase	ISS			PTHR11645:SF0	PYRROLINE-5-CARBOXYLATE REDUCTASE
P00018	EGF receptor signaling pathway	P00552	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	TAKRU|Ensembl=ENSTRUG00000005608|UniProtKB=H2SM93	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00627	ERK1-2	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	HUMAN|HGNC=4593|UniProtKB=Q13255	Metabotropic glutamate receptor 1	ISS			PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00059	p53 pathway	P01486	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P06212	DPP-SCW signaling pathway	P06258	TSG	DROME|FlyBase=FBgn0003865|UniProtKB=P54356	Protein twisted gastrulation	IDA	11260716	PubMed	PTHR12312:SF16	TWISTED GASTRULATION PROTEIN HOMOLOG 1-A-RELATED
P00053	T cell activation	P01307	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	IDA	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00010	B cell activation	P00398	IP3R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00053	T cell activation	P01312	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	BOVIN|Ensembl=ENSBTAG00000047202|UniProtKB=G3N3K3	Uncharacterized protein	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P05731	GABA-B receptor II signaling	P05752	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MOUSE|MGI=MGI=88396|UniProtKB=P12657	Muscarinic acetylcholine receptor M1	IDA	12181435	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=24667|UniProtKB=Q8TD08	Mitogen-activated protein kinase 15	TAS	10851062	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P02754	Methylcitrate cycle	P03028	Aconitase	HUMAN|HGNC=117|UniProtKB=P21399	Cytoplasmic aconitate hydratase	ISS			PTHR11670:SF32	CYTOPLASMIC ACONITATE HYDRATASE
P04393	Ras Pathway	P04570	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01153	GSK3	ORYSJ|EnsemblGenome=OS01G0296100|UniProtKB=Q94IZ2	Os01g0296100 protein	ISS	21361340	gi	PTHR24057:SF34	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01456	beta-arrestin	MOUSE|MGI=MGI=99474|UniProtKB=Q91YI4	Beta-arrestin-2	IDA	12464600	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	ANOGA|EnsemblGenome=AGAP000138|UniProtKB=Q66T33	AGAP000138-PB	ISS	85270494	PubMed	PTHR18945:SF531	NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA4, ISOFORM H
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00318	PKCs	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00018	EGF receptor signaling pathway	P00552	Ras	DICPU|Gene=DICPUDRAFT_91367|UniProtKB=F0ZB76	Putative uncharacterized protein rasD	ISS	85024887	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00034	Integrin signalling pathway	P00931	Integrin beta	PANTR|Ensembl=ENSPTRG00000005006|UniProtKB=H2Q615	Integrin beta	ISS	10741397	PubMed	PTHR10082:SF36	INTEGRIN BETA-7
P00023	General transcription regulation	P00660	RNA Polymerase II	MONDO|Ensembl=ENSMODG00000013540|UniProtKB=F7CLY1	Uncharacterized protein	ISS	2187864	PubMed	PTHR11800:SF2	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	MACMU|Ensembl=ENSMMUG00000010509|UniProtKB=F7B8E8	Clathrin heavy chain	ISS	9388255	PubMed	PTHR10292:SF7	CLATHRIN HEAVY CHAIN 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=619858|UniProtKB=P70579	Metabotropic glutamate receptor 8	IDA	9407094	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DANRE|ZFIN=ZDB-GENE-041210-195|UniProtKB=F1R506	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00057	Wnt signaling pathway	P01444	Wnt	RAT|RGD=1307644|UniProtKB=D3ZND6	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00053	T cell activation	P01312	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06785	ELK1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	RCA	11151091	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00047	PDGF signaling pathway	P01153	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12805548	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00051	TCA cycle	P01266	Pyruvate Dehydrogenase	RAT|RGD=69428|UniProtKB=Q64536	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	ISS			PTHR11947:SF15	PYRUVATE DEHYDROGENASE  ACETYL-TRANSFERRING   KINASE ISOZYME 2, MITOCHONDRIAL
P00006	Apoptosis signaling pathway	P00274	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00016	Cytoskeletal regulation by Rho GTPase	P00524	LIMK	HUMAN|HGNC=6613|UniProtKB=P53667	LIM domain kinase 1	ISS			PTHR44124:SF1	LIM DOMAIN KINASE 1
P04393	Ras Pathway	P04547	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00018	EGF receptor signaling pathway	P00557	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	IGI	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Ensembl=ENSCAFG00000000332|UniProtKB=F1P8E3	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00036	Interleukin signaling pathway	P00983	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	TAS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00050	Plasminogen activating cascade	P01257	tPA	HUMAN|HGNC=9051|UniProtKB=P00750	Tissue-type plasminogen activator	IDA	6572897	PubMed	PTHR44617:SF1	TISSUE-TYPE PLASMINOGEN ACTIVATOR
P00052	TGF-beta signaling pathway	P01275	P38	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00049	Parkinson disease	P01211	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00012	Cadherin signaling pathway	P00470	F-actin	XENTR|Xenbase=XB-GENE-480347|UniProtKB=Q6P640	Actin, alpha cardiac muscle 1	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04393	Ras Pathway	P04558	p38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00223	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CAEEL|WormBase=WBGene00006454|UniProtKB=G5EEN8	AEX-4	IC			PTHR19305:SF10	AEX-4
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MOUSE|MGI=MGI=102705|UniProtKB=P63213	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IDA	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04375	5HT3 type receptor mediated signaling pathway	P04422	5HT3 Rec	PANTR|Ensembl=ENSPTRG00000004300|UniProtKB=H2Q4T0	Uncharacterized protein	ISS	7509203	PubMed	PTHR18945:SF53	5-HYDROXYTRYPTAMINE RECEPTOR 3B
P00021	FGF signaling pathway	P00645	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	SCHPO|PomBase=SPBC32H8.12c|UniProtKB=P10989	Actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02783	Tryptophan biosynthesis	P03207	Tryptophan synthase A	LEPIN|EnsemblGenome=LA_3288|UniProtKB=Q8F150	Tryptophan synthase alpha chain	ISS			PTHR43455:SF1	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00552	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00047	PDGF signaling pathway	P01171	PLCgamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00051	TCA cycle	P01266	Pyruvate Dehydrogenase	HUMAN|HGNC=8806|UniProtKB=P08559	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial	RCA			PTHR11516:SF52	PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA, SOMATIC FORM, MITOCHONDRIAL
P00029	Huntington disease	P00786	ARF	CANLF|Ensembl=ENSCAFG00000012001|UniProtKB=F1PCE1	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF119	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 4C
P00038	JAK/STAT signaling pathway	P01027	STAT	CANLF|Ensembl=ENSCAFG00000015509|UniProtKB=F1PNW8	Signal transducer and activator of transcription	ISS	96102059	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	ISS	1482697	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00018	EGF receptor signaling pathway	P00539	14-3-3	MONDO|Ensembl=ENSMODG00000010174|UniProtKB=F6TA21	Uncharacterized protein	ISS	5803225	gi	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00050	Plasminogen activating cascade	P01254	pro-MMP-13	HUMAN|HGNC=7159|UniProtKB=P45452	Collagenase 3	IDA	8207000	PubMed	PTHR10201:SF165	COLLAGENASE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00639	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	7798194	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00048	PI3 kinase pathway	P01192	p110	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00642	MEK1-2	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05916	Opioid prodynorphin pathway	P06002	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00029	Huntington disease	P00796	Kainate receptor	MOUSE|MGI=MGI=95815|UniProtKB=P39087	Glutamate receptor ionotropic, kainate 2	IDA	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00019	Endothelin signaling pathway	P00591	PLCbeta	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	IC	http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	TAS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	IC	10704417	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00029	Huntington disease	P00775	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT2G43790|UniProtKB=Q39026	Mitogen-activated protein kinase 6	ISS	11707292	PubMed	PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P00020	FAS signaling pathway	P00610	MKK4	CANLF|Ensembl=ENSCAFG00000017851|UniProtKB=F1PBB6	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IGI	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	RCA	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00004	Alzheimer disease-presenilin pathway	P00110	Ire-1 N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000016799|UniProtKB=F1MM00	Uncharacterized protein	ISS	10619423	PubMed	PTHR13954:SF17	SERINE/THREONINE-PROTEIN KINASE/ENDORIBONUCLEASE IRE1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000012789|UniProtKB=F1MWF5	Uncharacterized protein	ISS	8078925	PubMed	PTHR22968:SF9	SERINE/THREONINE-PROTEIN KINASE D1
P00010	B cell activation	P00391	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00624	14-3-3	ORNAN|Ensembl=ENSOANG00000007305|UniProtKB=F6XW91	Uncharacterized protein	ISS	92283271	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00046	Oxidative stress response	P01137	MNK1/2	BOVIN|Ensembl=ENSBTAG00000018049|UniProtKB=E1BCH7	Uncharacterized protein	ISS	11463832	PubMed	PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CAEEL|WormBase=WBGene00004036|UniProtKB=G5EFI8	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00021	FGF signaling pathway	P00638	PLCgamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00047	PDGF signaling pathway	P01167	Ets	MOUSE|MGI=MGI=95455|UniProtKB=P27577	Protein C-ets-1	ISS	15699632	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	MONDO|Ensembl=ENSMODG00000020603|UniProtKB=F6ZBJ4	Uncharacterized protein	ISS	9039917	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	HUMAN|HGNC=144|UniProtKB=P63261	Actin, cytoplasmic 2	ISS	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00021	FGF signaling pathway	P00645	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=620308|UniProtKB=P30936	Somatostatin receptor type 3	IDA	12181435	PubMed	PTHR24229:SF42	SOMATOSTATIN RECEPTOR TYPE 3
P00054	Toll receptor signaling pathway	P01358	ERK1	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01142	p90RSK	CHICK|Ensembl=ENSGALG00000000366|UniProtKB=P18652	Ribosomal protein S6 kinase 2 alpha	ISS	2779569	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P05913	Enkephalin release	P05974	G-Protein (i)	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	12488551	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DROME|FlyBase=FBgn0000489|UniProtKB=P16912	Protein kinase DC2	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00005	Angiogenesis	P00221	JNK1	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	CHICK|Ensembl=ENSGALG00000009320|UniProtKB=Q4JIM4	Presenilin-1	TAS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	CANLF|Gene=PSEN1|UniProtKB=Q6RH31	Presenilin-1	ISS	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P00010	B cell activation	P00391	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01322	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00021	FGF signaling pathway	P00632	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01238	14-3-3	ORNAN|Ensembl=ENSOANG00000003572|UniProtKB=F7DGH9	Uncharacterized protein	ISS	6756037	gi	PTHR18860:SF16	14-3-3 PROTEIN ETA
P02731	Biotin biosynthesis	P02858	8-Amino-7-oxononanoate synthase	RHOBA|EnsemblGenome=RB3176|UniProtKB=Q7UUN9	8-amino-7-oxononanoate synthase	ISS			PTHR13693:SF77	8-AMINO-7-OXONONANOATE SYNTHASE
P00057	Wnt signaling pathway	P01455	Smad4	MOUSE|MGI=MGI=894293|UniProtKB=P97471	Mothers against decapentaplegic homolog 4	IDA	10693808	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	NAS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00018	EGF receptor signaling pathway	P00547	PP2A	DANRE|ZFIN=ZDB-GENE-030904-7|UniProtKB=Q8AXX6	Ppp2r5e2 protein	ISS	11007767	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MOUSE|MGI=MGI=1309999|UniProtKB=Q922R0	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2521|UniProtKB=P19020	D(3) dopamine receptor	IDA	1319557	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00020	FAS signaling pathway	P00615	JNK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	TAS	10207617	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	CANLF|Ensembl=ENSCAFG00000028654|UniProtKB=J9P702	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00048	PI3 kinase pathway	P01185	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	RCA			PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05730	Endogenous cannabinoid signaling	P05751	Galpha	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	BOVIN|Ensembl=ENSBTAG00000012628|UniProtKB=F1MUJ6	Uncharacterized protein	ISS	96032356	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	DROME|FlyBase=FBgn0031148|UniProtKB=Q9VRD9	Cystathionine beta-synthase	ISS			PTHR10314:SF8	CYSTATHIONINE BETA-SYNTHASE-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	XENTR|Xenbase=XB-GENE-491938|UniProtKB=Q6DIV8	Actin, alpha 1, skeletal muscle	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DANRE|ZFIN=ZDB-GENE-050417-267|UniProtKB=F1QUN8	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF263	ACTIN
P00018	EGF receptor signaling pathway	P00545	JNK1-3	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ARATH|TAIR=AT4G01370|UniProtKB=Q39024	Mitogen-activated protein kinase 4	IDA			PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	MACMU|Ensembl=ENSMMUG00000016428|UniProtKB=F7GU00	Metabotropic glutamate receptor 1 isoform alpha	ISS			PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00012	Cadherin signaling pathway	P00474	Wnt	TAKRU|Ensembl=ENSTRUG00000000172|UniProtKB=H2RJP1	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF103	PROTEIN WNT-4A
P00036	Interleukin signaling pathway	P00978	Jak	HUMAN|HGNC=6193|UniProtKB=P52333	Tyrosine-protein kinase JAK3	TAS	15179321	PubMed	PTHR24418:SF233	TYROSINE-PROTEIN KINASE JAK3
P00005	Angiogenesis	P00189	Fzd	PANTR|Ensembl=ENSPTRG00000028511|UniProtKB=H2R570	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF81	FRIZZLED-1
P02758	Ornithine degradation	P03055	Aminobutyraldehyde dehydrogenase	STRCO|Gene=CAC08409|UniProtKB=Q9F303	Uncharacterized protein	ISS			PTHR43104:SF2	L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL
P00053	T cell activation	P01332	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00944	Actin	MOUSE|MGI=MGI=87904|UniProtKB=P60710	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00048	PI3 kinase pathway	P01206	14-3-3	RAT|RGD=3980|UniProtKB=P63102	14-3-3 protein zeta/delta	ISS	92362864	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00547	PP2A	PANTR|Ensembl=ENSPTRG00000018180|UniProtKB=H2QT14	Protein phosphatase 2, regulatory subunit B', delta	ISS	10092233	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00029	Huntington disease	P00775	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00053	T cell activation	P01312	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DANRE|ZFIN=ZDB-GENE-000329-1|UniProtKB=Q7ZVI7	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P02749	Leucine biosynthesis	P03002	Isopropylmalate isomerase	AQUAE|EnsemblGenome=aq_940|UniProtKB=O67078	3-isopropylmalate dehydratase large subunit	ISS			PTHR43822:SF2	HOMOACONITASE, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	PANTR|Ensembl=ENSPTRG00000033819|UniProtKB=H2QV00	Actin related protein 2/3 complex, subunit 1A, 41kDa	ISS	12473693	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00048	PI3 kinase pathway	P01177	P110ACT	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04398	p53 pathway feedback loops 2	P04658	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00020	FAS signaling pathway	P00615	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04393	Ras Pathway	P04574	PLD	PANTR|Ensembl=ENSPTRG00000015626|UniProtKB=H2R1L6	Phospholipase D1, phosphatidylcholine-specific	ISS	10497874	PubMed	PTHR18896:SF57	PHOSPHOLIPASE D1
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01153	GSK3	CAEEL|WormBase=WBGene00001746|UniProtKB=Q9U2Q9	Glycogen synthase kinase-3	ISS	12615961	PubMed	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00629	PP2A	BOVIN|Ensembl=ENSBTAG00000009245|UniProtKB=Q0P594	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05913	Enkephalin release	G06045	preproenkephalin	RAT|RGD=68946|UniProtKB=P04094	Proenkephalin-A	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P05916	Opioid prodynorphin pathway	P06002	G-protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9441|UniProtKB=P51817	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MACMU|Ensembl=ENSMMUG00000016675|UniProtKB=F6VTB5	Uncharacterized protein	ISS	11554554	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00034	Integrin signalling pathway	P00907	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	IDA	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=17175|UniProtKB=Q9P212	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	12176394	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00057	Wnt signaling pathway	P01464	Pygo	MOUSE|MGI=MGI=1919385|UniProtKB=Q9D0P5	Pygopus homolog 1	ISS	11955446	PubMed	PTHR23194:SF3	PYGOPUS HOMOLOG 1
P00057	Wnt signaling pathway	P01448	CBP	HUMAN|HGNC=3373|UniProtKB=Q09472	Histone acetyltransferase p300	IDA	10823891	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00057	Wnt signaling pathway	P01438	PP2A	DANRE|ZFIN=ZDB-GENE-050417-441|UniProtKB=Q567Y8	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00810	GAPDH	PSEAE|EnsemblGenome=PA3001|UniProtKB=Q9HZK4	Glyceraldehyde-3-phosphate dehydrogenase	IPI			PTHR43454:SF1	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04661	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00048	PI3 kinase pathway	P01196	PDK1	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	11256888	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00552	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00016	Cytoskeletal regulation by Rho GTPase	P00519	ROCK	MOUSE|MGI=MGI=107926|UniProtKB=P70336	Rho-associated protein kinase 2	ISS			PTHR22988:SF28	RHO-ASSOCIATED PROTEIN KINASE 2
P02754	Methylcitrate cycle	P03028	Aconitase	PANTR|Ensembl=ENSPTRG00000020843|UniProtKB=H2QX43	Aconitate hydratase	ISS			PTHR11670:SF32	CYTOPLASMIC ACONITATE HYDRATASE
P00057	Wnt signaling pathway	P01444	Wnt	DANRE|ZFIN=ZDB-GENE-081003-1|UniProtKB=B0LK22	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	PANTR|Ensembl=ENSPTRG00000003502|UniProtKB=H2Q3E9	Uncharacterized protein	ISS	96032356	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	DROME|FlyBase=FBgn0010246|UniProtKB=Q23979	Myosin-IB	IC			PTHR13140:SF679	MYOSIN-IB
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	HUMAN|HGNC=7576|UniProtKB=P13533	Myosin-6	ISS	89264452	PubMed	PTHR13140:SF721	MYOSIN-6
P00034	Integrin signalling pathway	P00931	Integrin beta	PANTR|Ensembl=ENSPTRG00000002413|UniProtKB=H2Q1T1	Integrin beta	ISS	3487386	PubMed	PTHR10082:SF28	INTEGRIN BETA-1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00012	Cadherin signaling pathway	P00477	GSK3beta	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05913	Enkephalin release	P05971	CREB	BOVIN|Ensembl=ENSBTAG00000016060|UniProtKB=Q1LZH5	cAMP-responsive element modulator	ISS			PTHR22952:SF97	CAMP-RESPONSIVE ELEMENT MODULATOR
P04393	Ras Pathway	P04543	MEKK1/4	CANLF|Ensembl=ENSCAFG00000000760|UniProtKB=E2R9L4	Uncharacterized protein	ISS	602425	OMIM	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01457	GBeta	DAPPU|EnsemblGenome=DAPPUDRAFT_206575|UniProtKB=E9FUX0	Guanine nucleotide binding protein, beta subunit	ISS	9740024	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	CANLF|Ensembl=ENSCAFG00000032530|UniProtKB=J9P2I5	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF155	REGULATOR OF G-PROTEIN SIGNALING 18
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	DROME|FlyBase=FBgn0052396|UniProtKB=Q9VRX3	Probable tubulin beta chain CG32396	ISS	12932731	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	DROME|FlyBase=FBgn0000253|UniProtKB=P62152	Calmodulin	ISS			PTHR23050:SF245	AT16150P-RELATED
P02723	Adenine and hypoxanthine salvage pathway	P02804	Hypoxanthine phosphoribosyl transferase	BOVIN|Ensembl=ENSBTAG00000046220|UniProtKB=G3N0T0	Uncharacterized protein	ISS			PTHR43340:SF6	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE
P00059	p53 pathway	P01480	PTEN	TAKRU|Ensembl=ENSTRUG00000009851|UniProtKB=H2TJ90	Uncharacterized protein	IGI	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	CANLF|Ensembl=ENSCAFG00000015081|UniProtKB=E2RMT4	Uncharacterized protein	ISS	12932731	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00021	FGF signaling pathway	P00624	14-3-3	CANLF|Ensembl=ENSCAFG00000003386|UniProtKB=F6Y478	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00025	Hedgehog signaling pathway	P00682	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00054	Toll receptor signaling pathway	P01354	NFkappaB	HUMAN|HGNC=7795|UniProtKB=Q00653	Nuclear factor NF-kappa-B p100 subunit	ISS	20151924	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DANRE|ZFIN=ZDB-GENE-000329-3|UniProtKB=Q7ZVF9	Actin, cytoplasmic 2	ISS	3487386	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00005	Angiogenesis	P00206	Wnt	TAKRU|Ensembl=ENSTRUG00000016522|UniProtKB=H2UZ46	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	PANTR|Ensembl=ENSPTRG00000002849|UniProtKB=H2Q2F4	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00048	PI3 kinase pathway	P01188	Gbetagamma	CANLF|Ensembl=ENSCAFG00000015662|UniProtKB=E2RHY4	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00021	FGF signaling pathway	P00638	PLCgamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	RAT|RGD=67385|UniProtKB=Q8VGC3	Voltage-dependent L-type calcium channel subunit beta-2	IC	20088160	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	TAKRU|Ensembl=ENSTRUG00000012733|UniProtKB=H2U5K8	Uncharacterized protein	ISS			PTHR24070:SF289	SUBFAMILY NOT NAMED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	CAEEL|WormBase=WBGene00002173|UniProtKB=Q9Y0A1	Inositol 1,4,5-trisphosphate receptor itr-1	IC	9065779	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CAEEL|WormBase=WBGene00004036|UniProtKB=G5EFI8	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	HUMAN|HGNC=9508|UniProtKB=P49768	Presenilin-1	TAS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P05918	p38 MAPK pathway	P05920	MAPKAP-K2	PANTR|Ensembl=ENSPTRG00000001915|UniProtKB=H2Q104	Mitogen-activated protein kinase-activated protein kinase 2	ISS	8262198	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00019	Endothelin signaling pathway	P00591	PLCbeta	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	ECOLI|EcoGene=EG10135|UniProtKB=P00968	Carbamoyl-phosphate synthase large chain	ISS			PTHR11405:SF5	CAD PROTEIN
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00007	Axon guidance mediated by semaphorins	P00340	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	10802295	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00053	T cell activation	P01300	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05913	Enkephalin release	P05977	G-Protein (s)	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00996	STAT	HUMAN|HGNC=11364|UniProtKB=P40763	Signal transducer and activator of transcription 3	IC	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-7595|UniProtKB=Q6PBR4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	10395542	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	DAPPU|EnsemblGenome=DAPPUDRAFT_206575|UniProtKB=E9FUX0	Guanine nucleotide binding protein, beta subunit	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04393	Ras Pathway	P04541	p90RSK	MACMU|Ensembl=ENSMMUG00000020532|UniProtKB=F7D8E6	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF98	RIBOSOMAL PROTEIN S6 KINASE ALPHA-6
P00010	B cell activation	P00379	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06792	MISRII	MOUSE|MGI=MGI=105062|UniProtKB=Q8K592	Anti-Muellerian hormone type-2 receptor	RCA	9759503	PubMed	PTHR23255:SF49	ANTI-MUELLERIAN HORMONE TYPE-2 RECEPTOR
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00057	Wnt signaling pathway	P01465	Ggamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00006	Apoptosis signaling pathway	P00303	c-Jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	CHICK|Ensembl=ENSGALG00000003270|UniProtKB=F1NR31	Uncharacterized protein	ISS	11248120	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00036	Interleukin signaling pathway	P00996	STAT	HUMAN|HGNC=11364|UniProtKB=P40763	Signal transducer and activator of transcription 3	IC	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000017374|UniProtKB=F7H6T7	Uncharacterized protein	ISS	10051575	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00047	PDGF signaling pathway	P01151	PKB	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00049	Parkinson disease	P01238	14-3-3	MACMU|Ensembl=ENSMMUG00000004125|UniProtKB=F6XLR8	14-3-3 protein gamma	ISS	10407019	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176910	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00020	FAS signaling pathway	P00615	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01284	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DICDI|dictyBase=DDB_G0283907|UniProtKB=P34099	cAMP-dependent protein kinase catalytic subunit	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00057	Wnt signaling pathway	P01470	Frodo	XENTR|Xenbase=XB-GENE-478639|UniProtKB=Q66KC9	Dapper 1	ISS	11941372	PubMed	PTHR15919:SF12	DAPPER HOMOLOG 1
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	TAKRU|Ensembl=ENSTRUG00000005329|UniProtKB=H2SK54	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00005	Angiogenesis	P00249	PAK	BOVIN|Ensembl=ENSBTAG00000015670|UniProtKB=E1B7J7	Uncharacterized protein	ISS	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00019	Endothelin signaling pathway	P00573	signal peptidase	CAEBR|Gene=CBG04194|UniProtKB=A8WWE1	Signal peptidase complex catalytic subunit SEC11	ISS	2092035	PubMed	PTHR10806:SF6	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DROME|FlyBase=FBgn0259680|UniProtKB=P83099	Putative protein kinase C delta type homolog	ISS	3045562	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	PANTR|Ensembl=ENSPTRG00000017291|UniProtKB=H2QRK9	Catenin (Cadherin-associated protein), alpha 1, 102kDa	ISS	10456847	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IGI	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05913	Enkephalin release	P05977	G-Protein (s)	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00004	Alzheimer disease-presenilin pathway	P00165	E-cadherin N-terminal fragment	HUMAN|HGNC=1762|UniProtKB=P22223	Cadherin-3	TAS	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00254	GTPase	XENTR|Xenbase=XB-GENE-489222|UniProtKB=Q28GJ8	Ras homolog gene family, member A	ISS	11360179	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00035	Interferon-gamma signaling pathway	P00960	PTP	MOUSE|MGI=MGI=99511|UniProtKB=P35235	Tyrosine-protein phosphatase non-receptor type 11	TAS	8096088	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00059	p53 pathway	P01480	PTEN	MOUSE|MGI=MGI=2446460|UniProtKB=G5E8H5	MCG118205, isoform CRA_c	IGI			PTHR12305:SF32	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE TPTE2-RELATED
P00024	Glycolysis	P00680	Phosphoglyceromutase	YEAST|SGD=S000002179|UniProtKB=Q12008	Phosphoglycerate mutase 2	ISS	97313263	PubMed	PTHR11931:SF9	PHOSPHOGLYCERATE MUTASE 2-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	HUMAN|HGNC=1452|UniProtKB=P27482	Calmodulin-like protein 3	IDA	9753452	PubMed	PTHR23050:SF197	CALMODULIN-LIKE PROTEIN 3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	IDA	15572354	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	HUMAN|HGNC=4383|UniProtKB=P30679	Guanine nucleotide-binding protein subunit alpha-15	RCA			PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	G04694	p110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P04398	p53 pathway feedback loops 2	P04649	Myc	CHICK|Ensembl=ENSGALG00000016308|UniProtKB=P01109	Myc proto-oncogene protein	TAS	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	RCA	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P02775	Salvage pyrimidine ribonucleotides	P03155	Cytosine deaminase	AQUAE|EnsemblGenome=aq_903|UniProtKB=O67050	tRNA-specific adenosine deaminase	ISS			PTHR11079:SF149	TRNA-SPECIFIC ADENOSINE DEAMINASE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	XENTR|Xenbase=XB-GENE-494200|UniProtKB=F7CS79	Uncharacterized protein	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00022	General transcription by RNA polymerase I	P00657	TBP	METAC|EnsemblGenome=MA_0179|UniProtKB=Q8TU94	TATA-box-binding protein 2	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00005	Angiogenesis	P00243	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01446	Calcineurin	PANTR|Ensembl=ENSPTRG00000016315|UniProtKB=H2QPY6	Serine/threonine-protein phosphatase	ISS	12091710	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DAPPU|EnsemblGenome=DAPPUDRAFT_228751|UniProtKB=E9HGF5	Cytoplasmatic actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00034	Integrin signalling pathway	P00921	PINCH	MACMU|Ensembl=ENSMMUG00000009156|UniProtKB=F7HRP5	Uncharacterized protein	ISS	10022929	PubMed	PTHR24210:SF11	LIM AND SENESCENT CELL ANTIGEN-LIKE-CONTAINING DOMAIN PROTEIN 1-RELATED
P02741	Flavin biosynthesis	P02936	FAD synthetase	BACTN|EnsemblGenome=BT_2543|UniProtKB=Q8A4Q4	Riboflavin biosynthesis protein	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	IC	14765990	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	RCA	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00561	STAT	TAKRU|Ensembl=ENSTRUG00000015348|UniProtKB=H2UQK9	Signal transducer and activator of transcription	ISS	15452141	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000008719|UniProtKB=F1MZX0	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_56698|UniProtKB=C3XYC3	Putative uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00006	Apoptosis signaling pathway	P00313	IKK	MOUSE|MGI=MGI=1338071|UniProtKB=O88351	Inhibitor of nuclear factor kappa-B kinase subunit beta	IDA	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	PANTR|Ensembl=ENSPTRG00000006510|UniProtKB=H2Q8K1	Presenilin	ISS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CHICK|Ensembl=ENSGALG00000006576|UniProtKB=E1BUE5	Uncharacterized protein	ISS	20012997	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_127488|UniProtKB=C3XYC7	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P04393	Ras Pathway	P04570	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	CHICK|Ensembl=ENSGALG00000009405|UniProtKB=F1NKF1	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00002	Alpha adrenergic receptor signaling pathway	P00078	Alpha1A/1B/1C	MACMU|Ensembl=ENSMMUG00000005691|UniProtKB=F6U596	Uncharacterized protein	ISS	11781138	PubMed	PTHR24248:SF17	ALPHA-1B ADRENERGIC RECEPTOR
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	MACMU|Ensembl=ENSMMUG00000010678|UniProtKB=F7AXI7	Uncharacterized protein	ISS	3768139	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00006	Apoptosis signaling pathway	P00318	PKCs	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00059	p53 pathway	P01486	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	CAEEL|WormBase=WBGene00001338|UniProtKB=O44413	Glutamyl(E) Amino-acyl tRNA Synthetase	ISS			PTHR43311:SF2	GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01230	Src kinase	MOUSE|MGI=MGI=96756|UniProtKB=P06240	Proto-oncogene tyrosine-protein kinase LCK	IDA	11078745	PubMed	PTHR24418:SF39	TYROSINE-PROTEIN KINASE LCK
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00024	Glycolysis	P00679	Aldolase	RAT|RGD=2089|UniProtKB=P05065	Fructose-bisphosphate aldolase A	ISS	74094688	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	RCA	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=3025|UniProtKB=P21917	D(4) dopamine receptor	IDA	11248120	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00021	FGF signaling pathway	P00632	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IGI	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P06587	Nicotine pharmacodynamics pathway	P06605	KCNK3/9	RAT|RGD=61997|UniProtKB=O54912	Potassium channel subfamily K member 3	RCA	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00019	Endothelin signaling pathway	P00586	Gq	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05731	GABA-B receptor II signaling	P05755	Gbeta	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00012	Cadherin signaling pathway	P00470	F-actin	ORNAN|Ensembl=ENSOANG00000007581|UniProtKB=F6QWB7	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00045	Notch signaling pathway	P01113	Pen-2	DANRE|ZFIN=ZDB-GENE-000330-9|UniProtKB=Q90ZE4	Presenilin-2	IEP	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00049	Parkinson disease	P01242	Casein kinase I	ARATH|TAIR=AT4G28860|UniProtKB=Q8LPI7	Protein CASEIN KINASE I-LIKE 4	IDA	10617630	PubMed	PTHR11909:SF97	PROTEIN CASEIN KINASE I-LIKE 3-RELATED
P06959	CCKR signaling map	P07110	PLC_beta	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	RCA	9084447	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	ARATH|TAIR=AT3G52400|UniProtKB=Q9SVC2	Syntaxin-122	IC			PTHR19957:SF69	SYNTAXIN-121-RELATED
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	BOVIN|Ensembl=ENSBTAG00000007909|UniProtKB=F1MPE9	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00049	Parkinson disease	P01211	ERK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	IDA	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00004	Alzheimer disease-presenilin pathway	P00165	E-cadherin N-terminal fragment	MOUSE|MGI=MGI=88354|UniProtKB=P09803	Cadherin-1	TAS	8120095	PubMed	PTHR24027:SF319	CADHERIN-1
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	TETTS|EnsemblGenome=TTHERM_00575350|UniProtKB=Q22V65	TATA box-binding protein (TBP): present in archaea and protein	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	MACMU|Gene=CHRM1|UniProtKB=P56489	Muscarinic acetylcholine receptor M1	ISS	12915051	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	SCHPO|PomBase=SPCC622.12c|UniProtKB=P78804	NADP-specific glutamate dehydrogenase	ISS			PTHR43571:SF1	NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED
P00048	PI3 kinase pathway	P01192	p110	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	PANTR|Ensembl=ENSPTRG00000004718|UniProtKB=H2Q5I0	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01322	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01330	IKK	MOUSE|MGI=MGI=99484|UniProtKB=Q60680	Inhibitor of nuclear factor kappa-B kinase subunit alpha	IGI	14499113	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00645	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	20010089	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00251	cPLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00047	PDGF signaling pathway	P01146	Ikk	BOVIN|Ensembl=ENSBTAG00000007599|UniProtKB=Q95KV0	Inhibitor of nuclear factor kappa-B kinase subunit beta	RCA			PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00543	ERK1-2	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	BOVIN|Ensembl=ENSBTAG00000047202|UniProtKB=G3N3K3	Uncharacterized protein	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000020010|UniProtKB=F7GJC2	Uncharacterized protein	ISS	8120095	PubMed	PTHR44603:SF2	CADHERIN-17
P00010	B cell activation	P00398	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IGI	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00980	IRS1/2	BOVIN|Ensembl=ENSBTAG00000021308|UniProtKB=F1MYE0	Uncharacterized protein	ISS	5031805	gi	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00048	PI3 kinase pathway	P01200	SHIP	DROME|FlyBase=FBgn0259178|UniProtKB=B7Z0Q1	5PtaseI, isoform F	ISS			PTHR12997:SF2	TYPE I INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	RAT|RGD=1309329|UniProtKB=F1MAD0	Protein Lrp5	ISS	11907044	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00018	EGF receptor signaling pathway	P00555	MKK4,7	CHICK|Ensembl=ENSGALG00000001001|UniProtKB=F1P3T1	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00018	EGF receptor signaling pathway	P00547	PP2A	CHICK|Ensembl=ENSGALG00000011840|UniProtKB=F1NLM6	Uncharacterized protein	ISS	8703017	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00046	Oxidative stress response	P01135	p38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	TAS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00231	HSP27	MACMU|Ensembl=ENSMMUG00000022133|UniProtKB=F7H3G0	Alpha-crystallin B chain	ISS			PTHR11527:SF37	ALPHA-CRYSTALLIN B CHAIN
P00012	Cadherin signaling pathway	P00467	alpha-catenin	CANLF|Ensembl=ENSCAFG00000001315|UniProtKB=E2R9S7	Uncharacterized protein	ISS	10456847	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DICPU|Gene=DICPUDRAFT_46519|UniProtKB=F0Z796	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00056	VEGF signaling pathway	P01420	FAK	MOUSE|MGI=MGI=95481|UniProtKB=P34152	Focal adhesion kinase 1	ISS	12640026	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00021	FGF signaling pathway	P00628	JNK1-3	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IGI	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P02766	Phenylethylamine degradation	P03103	Phenylethylamine oxidase	MACMU|Ensembl=ENSMMUG00000001871|UniProtKB=F7GP66	Amine oxidase	ISS			PTHR10638:SF23	MEMBRANE PRIMARY AMINE OXIDASE
P05731	GABA-B receptor II signaling	P05753	Ca channel	RAT|RGD=628852|UniProtKB=Q02294	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	8386525	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00030	Hypoxia response via HIF activation	P00824	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	CANLF|Ensembl=ENSCAFG00000018560|UniProtKB=F1PJ01	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF335	MYOSIN-11
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=26234|UniProtKB=Q96H55	Unconventional myosin-XIX	IC			PTHR13140:SF289	UNCONVENTIONAL MYOSIN-XIX
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DANRE|ZFIN=ZDB-GENE-030131-172|UniProtKB=Q6IQR3	Actin, alpha, cardiac muscle 1a	IDA	14684598	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	DICDI|dictyBase=DDB_G0282813|UniProtKB=O96623	Actin-related protein 2/3 complex subunit 2	ISS			PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P04393	Ras Pathway	P04559	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00010	B cell activation	P00383	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CAEBR|Gene=CBG04581|UniProtKB=A8WXZ5	Protein CBR-GAR-3	ISS	11166329	PubMed	PTHR43914:SF8	MUSCARINIC ACETYLCHOLINE RECEPTOR GAR-3
P00057	Wnt signaling pathway	P01427	Naked	MACMU|Ensembl=ENSMMUG00000019868|UniProtKB=F7GTC1	Uncharacterized protein	ISS	11356022	PubMed	PTHR22611:SF2	PROTEIN NAKED CUTICLE HOMOLOG 1
P00059	p53 pathway	P01486	Akt	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	TAS	12655147	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01238	14-3-3	IXOSC|EnsemblGenome=ISCW011376|UniProtKB=B7Q5I4	Multifunctional chaperone, putative	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00036	Interleukin signaling pathway	P00996	STAT	MOUSE|MGI=MGI=103034|UniProtKB=P52633	Signal transducer and transcription activator 6	IC	14598258	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	CANLF|Ensembl=ENSCAFG00000010476|UniProtKB=F1PS94	Uncharacterized protein	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P04395	Vasopressin synthesis	P04593	Glycopeptide	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	IC	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	DROME|FlyBase=FBgn0000039|UniProtKB=P17644	Acetylcholine receptor subunit alpha-like 2	ISS	85270494	PubMed	PTHR18945:SF430	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-LIKE 2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DICPU|Gene=DICPUDRAFT_48914|UniProtKB=F0ZK40	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF154	ACTIN-17-RELATED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00092	TACE	RAT|RGD=620404|UniProtKB=Q9Z1K9	Disintegrin and metalloproteinase domain-containing protein 17	IDA	9774383	PubMed	PTHR11905:SF171	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17
P02749	Leucine biosynthesis	P03000	Branched chain amino acid aminotransferase	ANOGA|EnsemblGenome=AGAP000011|UniProtKB=Q7QEI9	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF44	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P00048	PI3 kinase pathway	P01199	Galpha	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CAEEL|WormBase=WBGene00006798|UniProtKB=O16000	Syntaxin-1A homolog	IC			PTHR19957:SF210	SYNTAXIN-1A HOMOLOG
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00036	Interleukin signaling pathway	P00990	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00053	T cell activation	P01307	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=99842|UniProtKB=Q02284	5-hydroxytryptamine receptor 1F	IDA	12181435	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00021	FGF signaling pathway	P00645	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00056	VEGF signaling pathway	P01420	FAK	BOVIN|Ensembl=ENSBTAG00000009578|UniProtKB=G3N3B7	Uncharacterized protein	ISS	9182576	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MONDO|Ensembl=ENSMODG00000023683|UniProtKB=F6T0L6	Uncharacterized protein (Fragment)	ISS			PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	BOVIN|Ensembl=ENSBTAG00000034854|UniProtKB=F1N246	Uncharacterized protein	ISS			PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00048	PI3 kinase pathway	P01189	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00021	FGF signaling pathway	P00648	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MACMU|Ensembl=ENSMMUG00000006253|UniProtKB=F7H582	Uncharacterized protein	ISS	93028552	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P05918	p38 MAPK pathway	P06015	p38gamma	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	RCA	8920915	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00018	EGF receptor signaling pathway	P00557	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	DROME|FlyBase=FBgn0010399|UniProtKB=Q24418	Glutamate [NMDA] receptor subunit 1	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P05734	Synaptic vesicle trafficking	P05774	NSF	MACMU|Ensembl=ENSMMUG00000005548|UniProtKB=F6YT14	Uncharacterized protein	ISS	11348590	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00029	Huntington disease	P00807	Actin	MOUSE|MGI=MGI=1913963|UniProtKB=P61161	Actin-related protein 2	ISS	11889126	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00019	Endothelin signaling pathway	P00577	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01284	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ORYSJ|EnsemblGenome=OS07G0435100|UniProtKB=Q8W423	26S proteasome regulatory particle non-ATPase subunit12	ISS			PTHR12387:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	BOVIN|Ensembl=ENSBTAG00000006495|UniProtKB=P11017	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P02723	Adenine and hypoxanthine salvage pathway	P02804	Hypoxanthine phosphoribosyl transferase	MYCTU|EnsemblGenome=Rv3624c|UniProtKB=P9WHQ9	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	IDA	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CHICK|Ensembl=ENSGALG00000019382|UniProtKB=E1BWK1	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00048	PI3 kinase pathway	P01179	PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	MOUSE|MGI=MGI=109284|UniProtKB=Q61144	Presenilin-2	TAS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00010	B cell activation	P00381	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	XENTR|Xenbase=XB-GENE-484012|UniProtKB=F6R871	Serine/threonine-protein kinase receptor	ISS	9395284	PubMed	PTHR23255:SF64	ACTIVIN RECEPTOR TYPE-2A
P04386	Histamine H2 receptor mediated signaling pathway	P04489	H2	MACMU|Ensembl=ENSMMUG00000014245|UniProtKB=F7C4E6	Uncharacterized protein	ISS	8817552	PubMed	PTHR43893:SF5	HISTAMINE H2 RECEPTOR
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00003	Alzheimer disease-amyloid secretase pathway	P00087	Fe65	BOVIN|Ensembl=ENSBTAG00000015655|UniProtKB=Q17QV1	Amyloid beta (A4) protein-binding, family B, member 1 (Fe65)	ISS	15115822	PubMed	PTHR14058:SF5	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1
P04393	Ras Pathway	P04566	Stat 1/3	MOUSE|MGI=MGI=103038|UniProtKB=P42227	Signal transducer and activator of transcription 3	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00587	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT1G01560|UniProtKB=Q9LMM5	Mitogen-activated protein kinase 11	ISS	12787066	PubMed	PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P00049	Parkinson disease	P01226	CDCrel-1	PANTR|Ensembl=ENSPTRG00000014066|UniProtKB=H2R735	Uncharacterized protein	ISS	11078524	PubMed	PTHR18884:SF68	SEPTIN-5
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000006999|UniProtKB=E1BDQ4	Uncharacterized protein	ISS	15858232	PubMed	PTHR13715:SF15	RYANODINE RECEPTOR 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000018853|UniProtKB=F6XSK8	Uncharacterized protein	ISS	12562507	PubMed	PTHR24229:SF42	SOMATOSTATIN RECEPTOR TYPE 3
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CANLF|Ensembl=ENSCAFG00000002617|UniProtKB=E2QUL1	Uncharacterized protein	ISS	11319238	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00016	Cytoskeletal regulation by Rho GTPase	P00519	ROCK	HUMAN|HGNC=10252|UniProtKB=O75116	Rho-associated protein kinase 2	ISS			PTHR22988:SF28	RHO-ASSOCIATED PROTEIN KINASE 2
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00020	FAS signaling pathway	P00610	MKK4	CHICK|Ensembl=ENSGALG00000001001|UniProtKB=F1P3T1	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	MONDO|Ensembl=ENSMODG00000012981|UniProtKB=F7CS91	Uncharacterized protein	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00034	Integrin signalling pathway	P00922	Collagen	PANTR|Ensembl=ENSPTRG00000022173|UniProtKB=H2QYZ9	Uncharacterized protein	ISS	10778855	PubMed	PTHR24023:SF847	COLLAGEN ALPHA-5 IV  CHAIN
P00047	PDGF signaling pathway	P01154	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00045	Notch signaling pathway	P01103	Next	BOVIN|Ensembl=ENSBTAG00000043971|UniProtKB=E1BPT8	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00018	EGF receptor signaling pathway	P00539	14-3-3	MONDO|Ensembl=ENSMODG00000013658|UniProtKB=F6TY10	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MOUSE|MGI=MGI=104589|UniProtKB=P63268	Actin, gamma-enteric smooth muscle	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	DROME|FlyBase=FBgn0004647|UniProtKB=P07207	Neurogenic locus Notch protein	IDA	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P02731	Biotin biosynthesis	P02857	Biotin synthase	ECOLI|EcoGene=EG10118|UniProtKB=P12996	Biotin synthase	ISS			PTHR22976:SF1	BIOTIN SYNTHASE, MITOCHONDRIAL
P02746	Heme biosynthesis	P02975	Uroporphyrinogen decarboxylase	YEAST|SGD=S000002454|UniProtKB=P32347	Uroporphyrinogen decarboxylase	ISS			PTHR21091:SF2	UROPORPHYRINOGEN DECARBOXYLASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01151	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05754	Ggamma	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000001583|UniProtKB=F7BBM1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00005	Angiogenesis	P00185	JAK1	HUMAN|HGNC=6190|UniProtKB=P23458	Tyrosine-protein kinase JAK1	IDA	11929133	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02763	Peptidoglycan biosynthesis	P03084	UDP-N-acetylmuramoylalanyl-D-glutamate 2,6-diaminopimelate ligase	GLOVI|EnsemblGenome=BAC91433|UniProtKB=Q7NFN2	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase	ISS			PTHR23135:SF4	UDP-N-ACETYLMUAMOYLALANYL-D-GLUTAMATE-2,6-DIAMINOPIMELATE LIGASE-RELATED
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	PANTR|Gene=DRD2|UniProtKB=P60026	D(2) dopamine receptor	ISS	2039532	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P02754	Methylcitrate cycle	P03031	2-Methylcitrate dehydratase	BACSU|EnsemblGenome=BSU24130|UniProtKB=P45859	2-methylcitrate dehydratase	ISS			PTHR16943:SF26	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00045	Notch signaling pathway	P01103	Next	BOVIN|Ensembl=ENSBTAG00000012817|UniProtKB=E1BDN7	Delta-like protein	ISS	1286675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	IPI	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	RAT|RGD=2246|UniProtKB=Q07652	Voltage-dependent R-type calcium channel subunit alpha-1E	IDA	14507926	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CHICK|Ensembl=ENSGALG00000009844|UniProtKB=P68034	Actin, alpha cardiac muscle 1	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00906	Rap1	MACMU|Ensembl=ENSMMUG00000011442|UniProtKB=F7B9T3	Ras-related protein Rap-1b	ISS	1904317	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IDA	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00059	p53 pathway	P04633	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00402	Jnk	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00012	Cadherin signaling pathway	P00477	GSK3beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_56687|UniProtKB=C3YC50	Putative uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00049	Parkinson disease	P01213	Cyclin E	RAT|RGD=2294|UniProtKB=P39949	G1/S-specific cyclin-E1	IDA	12628165	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	MACMU|Ensembl=ENSMMUG00000022075|UniProtKB=F7HP31	Uncharacterized protein	ISS			PTHR11606:SF13	GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL
P04395	Vasopressin synthesis	P04589	Signal Peptidase	SCHPO|PomBase=SPAC56F8.11|UniProtKB=Q10259	Probable microsomal signal peptidase subunit 3	IC	1546959	PubMed	PTHR12804:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 3
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	HUMAN|HGNC=24451|UniProtKB=Q8IZD4	mRNA-decapping enzyme 1B	ISS			PTHR16290:SF5	MRNA-DECAPPING ENZYME 1B
P00010	B cell activation	P00385	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	10540223	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00054	Toll receptor signaling pathway	P01355	AP1	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	8837781	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	BOVIN|Ensembl=ENSBTAG00000025337|UniProtKB=F1MZX6	Uncharacterized protein	ISS			PTHR13140:SF504	MYOSIN-13
P00029	Huntington disease	P00790	beta-Tubulin	HUMAN|HGNC=16257|UniProtKB=Q9H4B7	Tubulin beta-1 chain	TAS	12932731	PubMed	PTHR11588:SF112	TUBULIN BETA-1 CHAIN
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00034	Integrin signalling pathway	P00945	Parvin	CHICK|Ensembl=ENSGALG00000014201|UniProtKB=E1C891	Uncharacterized protein	ISS	11331308	PubMed	PTHR12114:SF7	BETA-PARVIN
P00057	Wnt signaling pathway	P01451	Galpha	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IDA	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	MACMU|Ensembl=ENSMMUG00000020534|UniProtKB=F6TWF0	Serine/threonine-protein kinase PAK 6	ISS			PTHR24361:SF182	SERINE/THREONINE-PROTEIN KINASE PAK 6
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00057	Wnt signaling pathway	P01457	GBeta	ANOGA|EnsemblGenome=AGAP005912|UniProtKB=Q7Q6D3	AGAP005912-PA	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00006	Apoptosis signaling pathway	P00274	JNK	CAEEL|WormBase=WBGene00002187|UniProtKB=O44408	GLH-binding kinase 1	ISS			PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04556	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	IDA	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00648	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00010	B cell activation	P00371	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	P01486	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	TAS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00045	Notch signaling pathway	P01118	Numb	MACMU|Ensembl=ENSMMUG00000020196|UniProtKB=F6WLR7	Uncharacterized protein	ISS	10468633	PubMed	PTHR11232:SF33	PROTEIN NUMB HOMOLOG
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00199	JNKK1	PANTR|Ensembl=ENSPTRG00000008783|UniProtKB=H2QCA7	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MOUSE|MGI=MGI=107824|UniProtKB=P51680	C-C chemokine receptor type 4	TAS	12009564	PubMed	PTHR10489:SF608	C-C CHEMOKINE RECEPTOR TYPE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	CANLF|Gene=MYH1|UniProtKB=Q076A6	Myosin-1	ISS	89264452	PubMed	PTHR13140:SF484	MYOSIN-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00029	Huntington disease	P00801	Fos protein	MACMU|Ensembl=ENSMMUG00000010574|UniProtKB=A5A6H2	C-fos	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	IC	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	RAT|RGD=3188|UniProtKB=Q9QW30	Neurogenic locus notch homolog protein 2	IDA	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00010	B cell activation	P00386	Calcineurin	CANLF|Ensembl=ENSCAFG00000014818|UniProtKB=E2RJ59	Serine/threonine-protein phosphatase	ISS	7532676	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P02749	Leucine biosynthesis	P03000	Branched chain amino acid aminotransferase	RAT|RGD=68948|UniProtKB=O35854	Branched-chain-amino-acid aminotransferase, mitochondrial	ISS			PTHR11825:SF39	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, MITOCHONDRIAL
P04393	Ras Pathway	P04548	ATF2	CANLF|Ensembl=ENSCAFG00000013332|UniProtKB=F1PCQ4	Uncharacterized protein	ISS	15218628	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P02746	Heme biosynthesis	P02981	Glutamate-1-semialdehyde aminotransferase	SULSO|EnsemblGenome=SSO0182|UniProtKB=Q980U5	Glutamate-1-semialdehyde 2,1-aminomutase	ISS			PTHR43713:SF3	GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02746	Heme biosynthesis	P02976	Protoporphyrinogen oxidase	MOUSE|MGI=MGI=104968|UniProtKB=P51175	Protoporphyrinogen oxidase	ISS			PTHR42923:SF3	PROTOPORPHYRINOGEN OXIDASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00749	RGS9	BOVIN|Gene=RGS9|UniProtKB=O46469	Regulator of G-protein signaling 9	IDA	8756726	PubMed	PTHR10845:SF170	REGULATOR OF G-PROTEIN SIGNALING 9
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04585	TRH	MOUSE|MGI=MGI=88390|UniProtKB=P01216	Glycoprotein hormones alpha chain	ISS			PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	176892	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MONDO|Ensembl=ENSMODG00000016595|UniProtKB=F6ZDB2	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P05918	p38 MAPK pathway	P06037	TAK1	MOUSE|MGI=MGI=1346877|UniProtKB=Q62073	Mitogen-activated protein kinase kinase kinase 7	RCA	10683140	PubMed	PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8663|UniProtKB=Q9Y5I3	Protocadherin alpha-1	IDA	8120095	PubMed	PTHR24028:SF92	PROTOCADHERIN ALPHA-1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	CAEEL|WormBase=WBGene00001680|UniProtKB=Q20636	Guanine nucleotide-binding protein subunit beta-2	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00006	Apoptosis signaling pathway	P00307	ELF2alpha	SULSO|EnsemblGenome=SSO1050|UniProtKB=Q97Z79	Translation initiation factor 2 subunit alpha	ISS			PTHR10602:SF0	EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1
P04398	p53 pathway feedback loops 2	P04657	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00647	SHP2	BOVIN|Ensembl=ENSBTAG00000002048|UniProtKB=F1N339	Tyrosine-protein phosphatase non-receptor type	ISS	1382983	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04413	K+ channel	BOVIN|Ensembl=ENSBTAG00000047488|UniProtKB=G3N1D1	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00009	Axon guidance mediated by netrin	P00363	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	ISS	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	ORNAN|Ensembl=ENSOANG00000006811|UniProtKB=F6WBD5	Uncharacterized protein	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00053	T cell activation	P01305	Calmodulin	BRAFL|Gene=BRAFLDRAFT_124869|UniProtKB=C3ZEW0	Putative uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF263	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00273	p53	MACMU|Ensembl=ENSMMUG00000008639|UniProtKB=P56424	Cellular tumor antigen p53	ISS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00021	FGF signaling pathway	P00629	PP2A	ARATH|TAIR=AT5G28900|UniProtKB=Q8VZQ4	Probable serine/threonine protein phosphatase 2A regulatory subunit B''gamma	ISS			PTHR14095:SF0	SERINE/THREONINE PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B''ALPHA-RELATED
P00005	Angiogenesis	P00206	Wnt	MACMU|Ensembl=ENSMMUG00000015709|UniProtKB=F6SLX4	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	IDA	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00036	Interleukin signaling pathway	P00990	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	RAT|RGD=3250|UniProtKB=P35465	Serine/threonine-protein kinase PAK 1	ISS	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00007	Axon guidance mediated by semaphorins	P00340	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00018	EGF receptor signaling pathway	P00547	PP2A	IXOSC|EnsemblGenome=ISCW014549|UniProtKB=B7QGY5	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	3755548	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00029	Huntington disease	P00811	Arp2/3 complex	BOVIN|Ensembl=ENSBTAG00000046248|UniProtKB=Q58CQ2	Actin-related protein 2/3 complex subunit 1B	ISS	12932731	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04393	Ras Pathway	P04552	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IDA	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00019	Endothelin signaling pathway	P00587	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	RAT|RGD=3274|UniProtKB=P23377	Furin	IDA	10956649	PubMed	PTHR42884:SF1	FURIN
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00047	PDGF signaling pathway	P01161	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	12068308	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00006	Apoptosis signaling pathway	P00321	HSP70	MACMU|Ensembl=ENSMMUG00000005217|UniProtKB=F7C3R1	78 kDa glucose-regulated protein	ISS	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00053	T cell activation	P01318	PKC-theta	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	11204774	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00021	FGF signaling pathway	P00624	14-3-3	ORNAN|Ensembl=ENSOANG00000007305|UniProtKB=F6XW91	Uncharacterized protein	ISS	12615066	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00029	Huntington disease	P00796	Kainate receptor	RAT|RGD=2735|UniProtKB=Q63273	Glutamate receptor ionotropic, kainate 5	IDA	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00005	Angiogenesis	P00234	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	8051109	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	HUMAN|HGNC=11428|UniProtKB=O60499	Syntaxin-10	ISS	10839363	PubMed	PTHR19957:SF106	SYNTAXIN-10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	BOVIN|Ensembl=ENSBTAG00000004242|UniProtKB=Q1JP79	Actin-related protein 2/3 complex subunit 1A	ISS	12473693	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00006	Apoptosis signaling pathway	P00260	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IDA	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	89186920	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00034	Integrin signalling pathway	P00927	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00019	Endothelin signaling pathway	P00566	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	8946911	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	YEAST|SGD=S000000135|UniProtKB=P28274	CTP synthase 1	ISS			PTHR11550:SF0	CTP SYNTHASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	HUMAN|HGNC=236|UniProtKB=O95622	Adenylate cyclase type 5	IDA	92317082	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	DANRE|ZFIN=ZDB-GENE-030616-53|UniProtKB=Q71E60	AMPA receptor subunit GluR3B	ISS	20112749	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	CAEEL|WormBase=WBGene00000201|UniProtKB=Q9U1R7	ARp2/3 compleX component	ISS	12932731	PubMed	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	MACMU|Ensembl=ENSMMUG00000018375|UniProtKB=F7H1D5	Neurogenic locus notch homolog protein 2 isoform 1 preproprotein	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00019	Endothelin signaling pathway	P00589	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05731	GABA-B receptor II signaling	P05754	Ggamma	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00006	Apoptosis signaling pathway	P00313	IKK	RAT|RGD=1306661|UniProtKB=G3V926	Conserved helix-loop-helix ubiquitous kinase (Predicted)	ISS	14499113	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00005	Angiogenesis	P00223	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01440	Cadherin	CANLF|Ensembl=ENSCAFG00000004836|UniProtKB=E2RM28	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF46	PROTOCADHERIN-8
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	IGI	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MOUSE|MGI=MGI=109248|UniProtKB=Q920H4	Muscarinic acetylcholine receptor M5	IDA	8100450	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	PSEAE|EnsemblGenome=PA3356|UniProtKB=Q9HYP0	Uncharacterized protein	ISS			PTHR43785:SF3	SUBFAMILY NOT NAMED
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	RAT|RGD=61862|UniProtKB=P19491	Glutamate receptor 2	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P05912	Dopamine receptor mediated signaling pathway	P05955	DBH	PANTR|Ensembl=ENSPTRG00000021521|UniProtKB=H2QY46	Uncharacterized protein	ISS	90219125	PubMed	PTHR10157:SF29	DOPAMINE BETA-HYDROXYLASE
P05731	GABA-B receptor II signaling	P05753	Ca channel	BOVIN|Ensembl=ENSBTAG00000007882|UniProtKB=G3X7Z2	Uncharacterized protein	ISS	14507926	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00059	p53 pathway	P04633	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P02783	Tryptophan biosynthesis	P03211	Phosphribosyl anthranilate isomerase	RHOBA|EnsemblGenome=RB8913|UniProtKB=Q7UMC3	N-(5'-phosphoribosyl)anthranilate isomerase	ISS			PTHR42894:SF1	N- 5'-PHOSPHORIBOSYL ANTHRANILATE ISOMERASE
P02738	De novo purine biosynthesis	P02909	GDP reductase	ARATH|TAIR=AT2G21790|UniProtKB=Q9SJ20	Ribonucleoside-diphosphate reductase large subunit	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00017	DNA replication	P00527	Histones	MACMU|Ensembl=ENSMMUG00000032354|UniProtKB=F6TK66	Histone H3	ISS	20448842	PubMed	PTHR11426:SF161	HISTONE H3.2-RELATED
P04393	Ras Pathway	P04559	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	PANTR|Gene=HTR1F|UniProtKB=Q9N2D9	5-hydroxytryptamine receptor 1F (Fragment)	ISS	11701344	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00054	Toll receptor signaling pathway	P01370	TAK1	XENTR|Xenbase=XB-GENE-481530|UniProtKB=F6U298	Uncharacterized protein	ISS	10683140	PubMed	PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P00057	Wnt signaling pathway	P01438	PP2A	TRIAD|EnsemblGenome=TriadG63380|UniProtKB=B3S653	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00167	CD44 transmembrane fragment	CHICK|Ensembl=ENSGALG00000007849|UniProtKB=F1NL98	Uncharacterized protein	IDA	12223485	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P00021	FGF signaling pathway	P00643	Raf-1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IGI	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00589	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00269	MAPK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	ISS	10514528	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P02782	Triacylglycerol metabolism	P03205	Triacylglycerol lipase	MOUSE|MGI=MGI=96216|UniProtKB=P27656	Hepatic triacylglycerol lipase	RCA			PTHR11610:SF2	HEPATIC TRIACYLGLYCEROL LIPASE
P00059	p53 pathway	P01486	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	TAS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00623	FGF	PANTR|Ensembl=ENSPTRG00000006008|UniProtKB=H2Q7R8	Fibroblast growth factor	ISS			PTHR11486:SF18	FIBROBLAST GROWTH FACTOR 14
P00006	Apoptosis signaling pathway	P00274	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	ISS	11707292	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00060	Ubiquitin proteasome pathway	P01491	E2	ARATH|TAIR=AT5G50870|UniProtKB=Q9FI61	Ubiquitin-conjugating enzyme E2 27	ISS			PTHR44020:SF2	UBIQUITIN-CONJUGATING ENZYME E2 K
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IDA	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	NEUCR|EnsemblGenome=EFNCRG00000000159|UniProtKB=F5HH30	Guanine nucleotide-binding protein beta subunit	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	TAS	11256888	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	ISS	10553940	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00025	Hedgehog signaling pathway	P00682	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	ISS	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00983	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	IC	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00054	Toll receptor signaling pathway	P01345	IKKalpha	MACMU|Ensembl=ENSMMUG00000018476|UniProtKB=F6X938	Uncharacterized protein	ISS	14499113	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	ISS	1319556	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P02757	O-antigen biosynthesis	P03045	dTDP-glucose 4,6-dehydratase	ARATH|TAIR=AT3G14790|UniProtKB=Q9LH76	Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM3	ISS			PTHR43000:SF8	TRIFUNCTIONAL UDP-GLUCOSE 4,6-DEHYDRATASE/UDP-4-KETO-6-DEOXY-D-GLUCOSE 3,5-EPIMERASE/UDP-4-KETO-L-RHAMNOSE-REDUCTASE RHM1-RELATED
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IPI	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	CAEEL|WormBase=WBGene00004287|UniProtKB=Q94124	Ras-related protein rac-2	ISS	21571425	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	CAEEL|WormBase=WBGene00000368|UniProtKB=O01661	Calcium Channel, Beta subunit	IC			PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00048	PI3 kinase pathway	P01200	SHIP	PANTR|Ensembl=ENSPTRG00000004031|UniProtKB=H2Q4C6	Inositol polyphosphate phosphatase-like 1	ISS	10610720	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=109323|UniProtKB=Q02152	5-hydroxytryptamine receptor 2B	IDA			PTHR24247:SF31	5-HYDROXYTRYPTAMINE RECEPTOR 2B
P00006	Apoptosis signaling pathway	P00289	FAS	MOUSE|MGI=MGI=95484|UniProtKB=P25446	Tumor necrosis factor receptor superfamily member 6	ISS	1371136	PubMed	PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	RCA	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	RCA	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS			PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	RAT|RGD=620351|UniProtKB=P18265	Glycogen synthase kinase-3 alpha	ISS	12086949	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P05913	Enkephalin release	P05972	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04572	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00004	Alzheimer disease-presenilin pathway	P00165	E-cadherin N-terminal fragment	RAT|RGD=621089|UniProtKB=F1LMI3	Cadherin 3, type 1, P-cadherin (Placental)	ISS	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P00054	Toll receptor signaling pathway	P01369	MKK1	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	RCA	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00034	Integrin signalling pathway	P00922	Collagen	MOUSE|MGI=MGI=2684334|UniProtKB=Q70UZ7	von Willebrand factor A domain-containing protein 2	IDA			PTHR44880:SF1	VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 2
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	DROME|FlyBase=FBgn0039532|UniProtKB=Q7JWS8	AT17867p	ISS			PTHR24072:SF157	AT17867P
P00021	FGF signaling pathway	P00623	FGF	TAKRU|Ensembl=ENSTRUG00000006744|UniProtKB=H2SVY7	Fibroblast growth factor	ISS	12496262	PubMed	PTHR11486:SF77	FIBROBLAST GROWTH FACTOR 13
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IDA	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00009	Axon guidance mediated by netrin	P00359	NFAT	RAT|RGD=1307690|UniProtKB=D4A0I8	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (Predicted), isoform CRA_b	ISS	9133421	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00006	Apoptosis signaling pathway	P00274	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04393	Ras Pathway	P04559	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	8649368	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00018	EGF receptor signaling pathway	P00545	JNK1-3	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04557	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	IDA	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00018	EGF receptor signaling pathway	P00564	Rac	ENTHI|EnsemblGenome=EHI_197840|UniProtKB=C4M8K6	Rho family GTPase	IGI	4757952	gi	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	IDA	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00056	VEGF signaling pathway	P01408	Akt/PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MOUSE|MGI=MGI=1313278|UniProtKB=Q9R216	Frizzled-9	TAS	8717036	PubMed	PTHR11309:SF79	FRIZZLED-9
P00021	FGF signaling pathway	P00645	Rac	DICPU|Gene=DICPUDRAFT_168754|UniProtKB=F0ZQR3	Rac1B, RHO family GTPase	ISS	12932731	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00034	Integrin signalling pathway	P00907	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	IDA	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00030	Hypoxia response via HIF activation	P00814	P300	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00629	PP2A	MOUSE|MGI=MGI=1926334|UniProtKB=Q76MZ3	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform	IGI	11994459	PubMed	PTHR10648:SF2	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 65 KDA REGULATORY SUBUNIT A ALPHA ISOFORM
P00029	Huntington disease	P00811	Arp2/3 complex	MACMU|Ensembl=ENSMMUG00000019342|UniProtKB=F6PVY4	Uncharacterized protein	ISS	12473693	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00034	Integrin signalling pathway	P00931	Integrin beta	DROME|FlyBase=FBgn0010395|UniProtKB=Q27591	Integrin beta-nu	IDA	3487386	PubMed	PTHR10082:SF59	INTEGRIN BETA-NU
P00057	Wnt signaling pathway	P01444	Wnt	RAT|RGD=1311441|UniProtKB=A0A0G2K3B7	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01414	PLC-gamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000022548|UniProtKB=F6Y9J9	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04663	Mdm2	BOVIN|Gene=MDM4|UniProtKB=Q2HJ21	Protein Mdm4	ISS			PTHR13844:SF20	PROTEIN MDM4
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	BOVIN|Ensembl=ENSBTAG00000011579|UniProtKB=F1N5C5	Muscarinic acetylcholine receptor	ISS	10069496	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	HUMAN|HGNC=6697|UniProtKB=O75197	Low-density lipoprotein receptor-related protein 5	IDA	11029006	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	HUMAN|HGNC=4571|UniProtKB=P42261	Glutamate receptor 1	ISS	12871085	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P06214	GBB signaling pathway	P06295	NEJ	DROME|FlyBase=FBgn0261617|UniProtKB=M9MS40	Nejire, isoform C	IGI	10075933	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P04397	p53 pathway by glucose deprivation	P04641	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00036	Interleukin signaling pathway	P00974	Receptor subunit beta	MOUSE|MGI=MGI=104579|UniProtKB=Q60837	Interleukin-12 receptor subunit beta-1	ISS			PTHR23036:SF51	INTERLEUKIN-12 RECEPTOR SUBUNIT BETA-1
P00025	Hedgehog signaling pathway	P00682	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00059	p53 pathway	P01485	p53	DANRE|ZFIN=ZDB-GENE-030814-2|UniProtKB=B0S576	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=1351342|UniProtKB=Q3UVX5	Metabotropic glutamate receptor 5	ISS			PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00034	Integrin signalling pathway	P00907	ERK	HUMAN|HGNC=6879|UniProtKB=Q16659	Mitogen-activated protein kinase 6	ISS	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MONDO|Ensembl=ENSMODG00000005623|UniProtKB=F7CFG8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	MOUSE|MGI=MGI=1347062|UniProtKB=Q9Z125	Cyclic AMP-responsive element-binding protein 3-like protein 1	ISS	123810	OMIM	PTHR22952:SF24	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 1
P00002	Alpha adrenergic receptor signaling pathway	P00078	Alpha1A/1B/1C	RAT|RGD=2055|UniProtKB=P43140	Alpha-1A adrenergic receptor	IC	11781138	PubMed	PTHR24248:SF16	ALPHA-1A ADRENERGIC RECEPTOR
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00029	Huntington disease	P00796	Kainate receptor	BOVIN|Ensembl=ENSBTAG00000009269|UniProtKB=F1MCM2	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	TAS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00012	Cadherin signaling pathway	P00471	Cadherin	BOVIN|Ensembl=ENSBTAG00000015058|UniProtKB=F1MW29	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF81	CADHERIN-4
P00011	Blood coagulation	P00408	Plasminogen	MACMU|Gene=PLG|UniProtKB=P12545	Plasminogen	ISS	2318848	PubMed	PTHR24261:SF6	PLASMINOGEN
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ORYSJ|EnsemblGenome=OS03G0836000|UniProtKB=Q10AZ4	Actin-3	IC	11889126	PubMed	PTHR11937:SF254	ACTIN-1-RELATED
P00018	EGF receptor signaling pathway	P00552	Ras	RAT|RGD=1311443|UniProtKB=D3Z8L7	Ras-related protein R-Ras	ISS	7997267	PubMed	PTHR24070:SF245	RAS-RELATED PROTEIN R-RAS
P00019	Endothelin signaling pathway	P00589	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	NAS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	TAS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02738	De novo purine biosynthesis	P02908	Phosphoribosylamine glycine ligase	SULSO|EnsemblGenome=SSO0635|UniProtKB=Q7LXR2	Phosphoribosylamine--glycine ligase	ISS			PTHR43472:SF1	PHOSPHORIBOSYLAMINE--GLYCINE LIGASE
P00012	Cadherin signaling pathway	P00470	F-actin	SCLS1|Gene=SS1G_08733|UniProtKB=A7ETS6	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	BOVIN|Gene=CACNB1|UniProtKB=Q9MZL7	Voltage-dependent L-type calcium channel subunit beta-1	IC	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00021	FGF signaling pathway	P00624	14-3-3	ORNAN|Ensembl=ENSOANG00000003572|UniProtKB=F7DGH9	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00056	VEGF signaling pathway	P01407	Erk	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00012	Cadherin signaling pathway	P00475	Frizzled	DANRE|ZFIN=ZDB-GENE-990415-218|UniProtKB=B3DIG4	Frizzled homolog 8c	IDA	11212302	PubMed	PTHR11309:SF126	FRIZZLED-5
P00059	p53 pathway	P04634	Cdc2	DROME|FlyBase=FBgn0004107|UniProtKB=P23573	Cyclin-dependent kinase 2	ISS			PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	RAT|RGD=3139|UniProtKB=Q29RW1	Myosin-4	ISS	89264452	PubMed	PTHR13140:SF657	MYOSIN-4
P00019	Endothelin signaling pathway	P00583	cPLA2	MACMU|Ensembl=ENSMMUG00000021423|UniProtKB=F7EEZ1	Phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	CHICK|Ensembl=ENSGALG00000019382|UniProtKB=E1BWK1	Uncharacterized protein	ISS	11431030	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	RCA	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00057	Wnt signaling pathway	P01435	SWI/SNF	ARATH|TAIR=AT3G57300|UniProtKB=Q8RXS6	DNA helicase INO80	IDA	11532957	PubMed	PTHR10799:SF868	DNA HELICASE INO80
P00029	Huntington disease	P00794	Hippi	PANTR|Ensembl=ENSPTRG00000015189|UniProtKB=H2QN22	Intraflagellar transport 57 homolog	ISS	11788820	PubMed	PTHR16011:SF0	INTRAFLAGELLAR TRANSPORT PROTEIN 57 HOMOLOG
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DICDI|dictyBase=DDB_G0289487|UniProtKB=P07829	Actin-3	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04379	Beta3 adrenergic receptor signaling pathway	P04449	Beta3	BOVIN|Ensembl=ENSBTAG00000017981|UniProtKB=P46626	Beta-3 adrenergic receptor	ISS	11943840	PubMed	PTHR24248:SF3	BETA-3 ADRENERGIC RECEPTOR
P00045	Notch signaling pathway	G01541	E(spl)-C genes	XENTR|Xenbase=XB-GENE-487830|UniProtKB=Q6PBD4	Transcription factor HES-4	ISS	14973298	PubMed	PTHR10985:SF125	TRANSCRIPTION FACTOR HES-4
P00056	VEGF signaling pathway	P01425	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	22040490	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P02757	O-antigen biosynthesis	P03046	dTDP-glucose pyrophosphorylase	DEIRA|EnsemblGenome=DR_A0031|UniProtKB=Q9RZC3	Glucose-1-phosphate thymidylyltransferase, putative	ISS			PTHR42883:SF2	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00543	ERK1-2	ARATH|TAIR=AT4G01370|UniProtKB=Q39024	Mitogen-activated protein kinase 4	ISS			PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00383	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IDA	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00006	Apoptosis signaling pathway	P00269	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CANLF|Ensembl=ENSCAFG00000008653|UniProtKB=F1PE26	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00189	Fzd	DROME|FlyBase=FBgn0001085|UniProtKB=P18537	Frizzled	ISS			PTHR11309:SF47	FRIZZLED
P06664	Gonadotropin-releasing hormone receptor pathway	P06739	MEK1/2	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	RCA	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00034	Integrin signalling pathway	P00932	FAK	CANLF|Ensembl=ENSCAFG00000001217|UniProtKB=E2RGP8	Uncharacterized protein (Fragment)	ISS	12640026	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00054	Toll receptor signaling pathway	P01375	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MOUSE|MGI=MGI=2444552|UniProtKB=Q8BFZ3	Beta-actin-like protein 2	IC	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	DICDI|dictyBase=DDB_G0279911|UniProtKB=P34093	Nucleoside diphosphate kinase, mitochondrial	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06781	Dnm1	MOUSE|MGI=MGI=107384|UniProtKB=P39053	Dynamin-1	RCA			PTHR11566:SF32	DYNAMIN-1
P00021	FGF signaling pathway	P00628	JNK1-3	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01162	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00634	MEKK1-5	RAT|RGD=620966|UniProtKB=Q62925	Mitogen-activated protein kinase kinase kinase 1	IGI	8643568	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00729	Goalpha	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	IDA	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00035	Interferon-gamma signaling pathway	P00958	PIAS	HUMAN|HGNC=2752|UniProtKB=O75925	E3 SUMO-protein ligase PIAS1	TAS	8682149	PubMed	PTHR10782:SF11	E3 SUMO-PROTEIN LIGASE PIAS1
P00059	p53 pathway	P04609	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00030	Hypoxia response via HIF activation	P00819	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	TAS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00373	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IGI	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	CAEEL|WormBase=WBGene00004769|UniProtKB=P52166	Presenilin sel-12	TAS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	HUMAN|HGNC=4432|UniProtKB=P17174	Aspartate aminotransferase, cytoplasmic	ISS			PTHR11879:SF3	ASPARTATE AMINOTRANSFERASE, CYTOPLASMIC
P00034	Integrin signalling pathway	P00914	Filamin	HUMAN|HGNC=3755|UniProtKB=O75369	Filamin-B	IPI	9722563	PubMed	PTHR43998:SF3	FILAMIN-B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00005	Angiogenesis	P00208	MEKK1	HUMAN|HGNC=6848|UniProtKB=Q13233	Mitogen-activated protein kinase kinase kinase 1	RCA			PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00029	Huntington disease	P00796	Kainate receptor	BOVIN|Ensembl=ENSBTAG00000034854|UniProtKB=F1N246	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00047	PDGF signaling pathway	P01159	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00010	B cell activation	P00369	MEKK	RAT|RGD=620967|UniProtKB=F1M9D0	Protein Map3k2	ISS	8621389	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MOUSE|MGI=MGI=109349|UniProtKB=P16951	Cyclic AMP-dependent transcription factor ATF-2	TAS	7875593	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000002016|UniProtKB=F1P3G1	Protein kinase C delta type	IC	11880265	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00060	Ubiquitin proteasome pathway	P01491	E2	MACMU|Ensembl=ENSMMUG00000002410|UniProtKB=F6PPG7	Ubiquitin-conjugating enzyme E2 D4	ISS			PTHR24068:SF24	UBIQUITIN-CONJUGATING ENZYME E2 D4
P00034	Integrin signalling pathway	P00944	Actin	BRAFL|Gene=BRAFLDRAFT_56687|UniProtKB=C3YC50	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CAEEL|WormBase=WBGene00003186|UniProtKB=Q10664	Dual specificity mitogen-activated protein kinase kinase mek-2	IGI	22022015	PubMed	PTHR24361:SF629	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1
P05730	Endogenous cannabinoid signaling	P05746	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01336	Jnk	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01444	Wnt	DANRE|ZFIN=ZDB-GENE-990415-278|UniProtKB=P43446	Protein Wnt-10a	IDA	11266476	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P04393	Ras Pathway	P04558	p38	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	IDA	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00025	Hedgehog signaling pathway	P00691	CBP	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	CHICK|Gene=CHRM4|UniProtKB=P17200	Muscarinic acetylcholine receptor M4	ISS	11166329	PubMed	PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00006	Apoptosis signaling pathway	P00270	Bcl-2	HUMAN|HGNC=990|UniProtKB=P10415	Apoptosis regulator Bcl-2	IDA	11323415	PubMed	PTHR11256:SF11	APOPTOSIS REGULATOR BCL-2
P00018	EGF receptor signaling pathway	P00558	SOS	DROME|FlyBase=FBgn0001965|UniProtKB=P26675	Protein son of sevenless	ISS	476780	gi	PTHR23113:SF99	PROTEIN SON OF SEVENLESS
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	IDA	97320448	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00047	PDGF signaling pathway	P01154	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	BOVIN|Ensembl=ENSBTAG00000004279|UniProtKB=P61585	Transforming protein RhoA	ISS	12039949	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00005	Angiogenesis	P00199	JNKK1	CANLF|Ensembl=ENSCAFG00000017851|UniProtKB=F1PBB6	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00014	Cholesterol biosynthesis	P00497	Anosterol synthase	MACMU|Ensembl=ENSMMUG00000022329|UniProtKB=F6X625	Terpene cyclase/mutase family member	ISS	P38604	SPACC	PTHR11764:SF20	LANOSTEROL SYNTHASE
P00019	Endothelin signaling pathway	P00590	IP3 R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05916	Opioid prodynorphin pathway	P05999	provasopressin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00053	T cell activation	P01319	PAK	XENTR|Xenbase=XB-GENE-966302|UniProtKB=F6T2E7	Uncharacterized protein	ISS	10644687	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00045	Notch signaling pathway	P01103	Next	RAT|RGD=3188|UniProtKB=Q9QW30	Neurogenic locus notch homolog protein 2	IEP	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00019	Endothelin signaling pathway	P00583	cPLA2	CANLF|Ensembl=ENSCAFG00000013778|UniProtKB=F6UQ33	Phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00025	Hedgehog signaling pathway	P00692	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00052	TGF-beta signaling pathway	P01288	FKBP12	CAEEL|WormBase=WBGene00001427|UniProtKB=Q9U2Q8	Peptidyl-prolyl cis-trans isomerase	ISS			PTHR10516:SF341	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE
P00010	B cell activation	P00402	Jnk	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00054	Toll receptor signaling pathway	P01369	MKK1	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	DICDI|dictyBase=DDB_G0276835|UniProtKB=Q86B00	Type-1 glutamine synthetase 1	ISS			PTHR43785:SF2	TYPE-1 GLUTAMINE SYNTHETASE 1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00049	Parkinson disease	P01211	ERK	BOVIN|Ensembl=ENSBTAG00000001014|UniProtKB=A5PKJ4	Mitogen-activated protein kinase 7	ISS	15085193	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P05913	Enkephalin release	G06045	preproenkephalin	BOVIN|Ensembl=ENSBTAG00000004924|UniProtKB=P01211	Proenkephalin-A	IC	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	HUMAN|HGNC=7573|UniProtKB=P11055	Myosin-3	ISS	10938134	PubMed	PTHR13140:SF427	MYOSIN-3
P00057	Wnt signaling pathway	P01444	Wnt	PANTR|Ensembl=ENSPTRG00000004892|UniProtKB=H2Q5U3	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=24667|UniProtKB=Q8TD08	Mitogen-activated protein kinase 15	IDA	10851062	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P05915	Opioid proenkephalin pathway	P05994	G-protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	XENTR|Xenbase=XB-GENE-481480|UniProtKB=Q5XGI6	Casein kinase 1, epsilon	ISS	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CHICK|Ensembl=ENSGALG00000015434|UniProtKB=F1NU20	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02747	Histidine biosynthesis	P02986	Phosphoribosyl ATP pyrophosphatase	THEMA|EnsemblGenome=TM_1035|UniProtKB=Q9X0C5	Histidine biosynthesis bifunctional protein HisIE	ISS			PTHR42945:SF1	HISTIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN HISIE, CHLOROPLASTIC
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00010	B cell activation	P00398	IP3R	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	IGI	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04393	Ras Pathway	P04558	p38	BOVIN|Ensembl=ENSBTAG00000030182|UniProtKB=G3X793	Mitogen-activated protein kinase	ISS	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	CHICK|Ensembl=ENSGALG00000013981|UniProtKB=Q9YGV8	TATA box-binding protein-like protein 1	ISS	10454611	PubMed	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	HUMAN|HGNC=4042|UniProtKB=Q9ULV1	Frizzled-4	TAS	11212302	PubMed	PTHR11309:SF23	FRIZZLED-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00049	Parkinson disease	P01219	SAPK	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	ISS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00018	EGF receptor signaling pathway	P00548	RKIP	DROME|FlyBase=FBgn0011294|UniProtKB=P54185	Putative odorant-binding protein A5	IGI	94121915	PubMed	PTHR11362:SF28	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00047	PDGF signaling pathway	P01153	GSK3	NEUCR|EnsemblGenome=EFNCRG00000003957|UniProtKB=V5ILY7	Protein kinase gsk3	ISS	11995474	gi	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00034	Integrin signalling pathway	P00914	Filamin	BOVIN|Ensembl=ENSBTAG00000011190|UniProtKB=F1N169	Uncharacterized protein	ISS	9722563	PubMed	PTHR43998:SF6	FILAMIN-A
P00054	Toll receptor signaling pathway	P01380	TLR1,2,6	MOUSE|MGI=MGI=1346060|UniProtKB=Q9QUN7	Toll-like receptor 2	ISS			PTHR24365:SF17	TOLL-LIKE RECEPTOR 2
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04393	Ras Pathway	P04558	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IDA	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00049	Parkinson disease	P01211	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04542	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00006	Apoptosis signaling pathway	P00321	HSP70	DROME|FlyBase=FBgn0266599|UniProtKB=P11147	Heat shock 70 kDa protein cognate 4	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P04393	Ras Pathway	P04570	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02781	Threonine biosynthesis	P03189	Aspartate kinase	STRCO|Gene=CAB45482|UniProtKB=Q9XAI7	Aspartokinase	ISS			PTHR21499:SF3	ASPARTOKINASE
P00057	Wnt signaling pathway	P01438	PP2A	PANTR|Ensembl=ENSPTRG00000017238|UniProtKB=H2QRH7	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00586	Gq	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00018	EGF receptor signaling pathway	P00539	14-3-3	CAEEL|WormBase=WBGene00001502|UniProtKB=Q20655	14-3-3-like protein 2	IGI	97315111	PubMed	PTHR18860:SF13	14-3-3 PROTEIN ZETA
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	RAT|RGD=2345|UniProtKB=P04757	Neuronal acetylcholine receptor subunit alpha-3	IC	85270494	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=1920423|UniProtKB=Q8VHR0	Protocadherin 18	IDA	8120095	PubMed	PTHR24028:SF9	PROTOCADHERIN-18
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02772	Pyruvate metabolism	P03137	Citrate Lyase	STRCO|Gene=CAC36574|UniProtKB=Q99Q47	Putative lysase	ISS			PTHR32308:SF8	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=7576|UniProtKB=P13533	Myosin-6	IC	89264452	PubMed	PTHR13140:SF721	MYOSIN-6
P00045	Notch signaling pathway	P01119	NIct	MOUSE|MGI=MGI=97364|UniProtKB=O35516	Neurogenic locus notch homolog protein 2	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	CHICK|Gene=BMPR1B|UniProtKB=Q05438	Bone morphogenetic protein receptor type-1B	TAS	10683140	PubMed	PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00048	PI3 kinase pathway	P01179	PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00221	JNK1	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02721	ATP synthesis	P02798	Cyt C	MACMU|Ensembl=ENSMMUG00000031713|UniProtKB=F7BU07	Uncharacterized protein	ISS	4954366	PubMed	PTHR11961:SF15	CYTOCHROME C
P00036	Interleukin signaling pathway	P00987	SRF	CANLF|Ensembl=ENSCAFG00000001829|UniProtKB=F1PH12	Uncharacterized protein	ISS	15647354	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00059	p53 pathway	P04609	PI3K	RAT|RGD=1306541|UniProtKB=D3ZVF3	Phosphoinositide-3-kinase, class 2, beta polypeptide (Predicted)	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00052	TGF-beta signaling pathway	P01286	TGFbeta	XENTR|Xenbase=XB-GENE-481784|UniProtKB=F6X227	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF44	GROWTH/DIFFERENTIATION FACTOR 5
P00034	Integrin signalling pathway	P00938	Cdc42	TAKRU|Ensembl=ENSTRUG00000013411|UniProtKB=H2UB84	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00018	EGF receptor signaling pathway	P00552	Ras	NEUCR|EnsemblGenome=EFNCRG00000003448|UniProtKB=Q01387	Protein ras-2	ISS			PTHR24070:SF293	SMALL GTPASE
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	MOUSE|MGI=MGI=106677|UniProtKB=Q8BRU6	Synaptic vesicular amine transporter	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P04393	Ras Pathway	P04547	Ras	XENTR|Xenbase=XB-GENE-6036229|UniProtKB=Q66JH1	Kras2 protein	ISS			PTHR24070:SF381	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00220	c-Jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04393	Ras Pathway	P04546	GSK3	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	IDA	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00005	Angiogenesis	P00224	PDGF	CHICK|Ensembl=ENSGALG00000012178|UniProtKB=F1NE37	Uncharacterized protein	ISS			PTHR11633:SF2	PLATELET-DERIVED GROWTH FACTOR SUBUNIT B
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00018	EGF receptor signaling pathway	P00557	PI3K	DROME|FlyBase=FBgn0015278|UniProtKB=Q7K3H0	LD28067p	IGI	14526383	PubMed	PTHR10048:SF64	LD28067P
P00036	Interleukin signaling pathway	P00981	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00021	FGF signaling pathway	P00644	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IGI	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TAKRU|Ensembl=ENSTRUG00000007989|UniProtKB=P68140	Actin, alpha skeletal muscle A	IC	11889139	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00019	Endothelin signaling pathway	P00590	IP3 R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IGI	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00019	Endothelin signaling pathway	P00568	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	3045562	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00049	Parkinson disease	P01224	UbcH7	MACMU|Ensembl=ENSMMUG00000004096|UniProtKB=F6ZC17	Uncharacterized protein	RCA			PTHR24068:SF67	UBIQUITIN-CONJUGATING ENZYME E2 L3
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	MACMU|Ensembl=ENSMMUG00000019999|UniProtKB=F7FNE2	Uncharacterized protein	ISS	12135927	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02779	Thiamin biosynthesis	P03173	Thiamin phosphate synthase	DEIRA|EnsemblGenome=DR_A0174|UniProtKB=Q9RYX9	Thiamine-phosphate synthase	ISS			PTHR20857:SF15	THIAMINE BIOSYNTHETIC BIFUNCTIONAL ENZYME
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05915	Opioid proenkephalin pathway	P05987	peptide F	PANTR|Ensembl=ENSPTRG00000020270|UniProtKB=H2QW70	Proenkephalin	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00053	T cell activation	P01294	NFAT	MOUSE|MGI=MGI=1920431|UniProtKB=Q8K120	Nuclear factor of activated T-cells, cytoplasmic 4	IGI	12015605	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00046	Oxidative stress response	P01129	JNK1/2	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CANLF|Ensembl=ENSCAFG00000008756|UniProtKB=F2Z4N8	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00010	B cell activation	P00391	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	HUMAN|HGNC=6053|UniProtKB=P12268	Inosine-5'-monophosphate dehydrogenase 2	ISS			PTHR11911:SF121	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2
P00005	Angiogenesis	P00243	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01171	PLCgamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00025	Hedgehog signaling pathway	P00691	CBP	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00034	Integrin signalling pathway	P00925	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00007	Axon guidance mediated by semaphorins	P00330	CRAM	MONDO|Ensembl=ENSMODG00000015761|UniProtKB=F6ZT50	Uncharacterized protein	ISS	11034345	PubMed	PTHR11647:SF58	DIHYDROPYRIMIDINASE-RELATED PROTEIN 5
P00047	PDGF signaling pathway	P01162	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IDA	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000003043|UniProtKB=P63212	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	DROME|FlyBase=FBgn0011582|UniProtKB=P41596	Dopamine receptor 1	ISS	11248120	PubMed	PTHR43893:SF6	DOPAMINE RECEPTOR 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	RAT|RGD=68385|UniProtKB=D4A055	Calcium channel, voltage-dependent, beta 4 subunit, isoform CRA_b	IC			PTHR11824:SF7	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00059	p53 pathway	G04694	p110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00054	Toll receptor signaling pathway	P01343	IRAK1	HUMAN|HGNC=6112|UniProtKB=P51617	Interleukin-1 receptor-associated kinase 1	IDA	96180673	PubMed	PTHR24419:SF1	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1
P00036	Interleukin signaling pathway	P00973	PKB	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00193	SOS-1	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ORYSJ|EnsemblGenome=OS05G0106600|UniProtKB=Q65XH8	Os05g0106600 protein	IC	11889126	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00045	Notch signaling pathway	P01114	Ntm	MACMU|Ensembl=ENSMMUG00000018375|UniProtKB=F7H1D5	Neurogenic locus notch homolog protein 2 isoform 1 preproprotein	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00048	PI3 kinase pathway	P01181	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00029	Huntington disease	P00777	CBP	ARATH|TAIR=AT1G79000|UniProtKB=Q9C5X9	Histone acetyltransferase HAC1	IDA	8413673	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00029	Huntington disease	P00805	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	ARATH|TAIR=AT3G57610|UniProtKB=Q96529	Adenylosuccinate synthetase, chloroplastic	IEP	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	CANLF|Ensembl=ENSCAFG00000028654|UniProtKB=J9P702	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P05918	p38 MAPK pathway	P06020	p38delta	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	RCA	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ARATH|TAIR=AT5G09810|UniProtKB=P53492	Actin-7	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	HUMAN|HGNC=4580|UniProtKB=Q13002	Glutamate receptor ionotropic, kainate 2	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00005	Angiogenesis	P00256	PLC-gamma	DROME|FlyBase=FBgn0003416|UniProtKB=Q9VXH3	Phosphoinositide phospholipase C	ISS			PTHR10336:SF91	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00021	FGF signaling pathway	P00641	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	HUMAN|HGNC=1954|UniProtKB=P08912	Muscarinic acetylcholine receptor M5	TAS	12181435	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00004	Alzheimer disease-presenilin pathway	P00168	E-cadherin intracellular fragment	MOUSE|MGI=MGI=88356|UniProtKB=P10287	Cadherin-3	IDA	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P00013	Cell cycle	P00480	Proteasome	ARATH|TAIR=AT5G23540|UniProtKB=Q9LT08	26S proteasome non-ATPase regulatory subunit 14 homolog	NAS	15237785	gi	PTHR10410:SF13	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 14 HOMOLOG
P00035	Interferon-gamma signaling pathway	P00959	IFNGR1	MACMU|Ensembl=ENSMMUG00000005508|UniProtKB=F7FLL3	Uncharacterized protein	ISS			PTHR20859:SF46	INTERFERON GAMMA RECEPTOR 2
P00053	T cell activation	P01305	Calmodulin	BOVIN|Ensembl=ENSBTAG00000014583|UniProtKB=P62157	Calmodulin	ISS	7514101	PubMed	PTHR23050:SF335	CALMODULIN, STRIATED MUSCLE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	STRCO|EnsemblGenome=CAB75393|UniProtKB=P50589	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	ISS	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00029	Huntington disease	P00780	Microtubule	XENTR|Xenbase=XB-GENE-491121|UniProtKB=Q6P367	Tubulin, beta 2B	ISS	12932731	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00010	B cell activation	P00388	PLC gamma2	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	IGI	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00046	Oxidative stress response	P01135	p38	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	TAS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00018	EGF receptor signaling pathway	P00546	GAP	PANTR|Ensembl=ENSPTRG00000008970|UniProtKB=H2QCM0	Neurofibromin 1	ISS	18587532	gi	PTHR10194:SF60	NEUROFIBROMIN
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	ARATH|TAIR=AT4G01370|UniProtKB=Q39024	Mitogen-activated protein kinase 4	TAS			PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=8156|UniProtKB=P35372	Mu-type opioid receptor	IDA	11259487	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ARATH|TAIR=AT1G60490|UniProtKB=P42339	Phosphatidylinositol 3-kinase VPS34	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00036	Interleukin signaling pathway	P00962	ELK	HUMAN|HGNC=3325|UniProtKB=P41970	ETS domain-containing protein Elk-3	IC			PTHR11849:SF172	ETS DOMAIN-CONTAINING PROTEIN ELK-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000014751|UniProtKB=H2R8D8	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00017	DNA replication	P00537	RPA	MACMU|Ensembl=ENSMMUG00000018172|UniProtKB=F7EYD7	Replication protein A 32 kDa subunit	ISS	11731442	PubMed	PTHR13989:SF10	REPLICATION PROTEIN A 32 KDA SUBUNIT
P00005	Angiogenesis	P00251	cPLA2	CANLF|Ensembl=ENSCAFG00000013778|UniProtKB=F6UQ33	Phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00034	Integrin signalling pathway	P00931	Integrin beta	ANOGA|EnsemblGenome=AGAP010233|UniProtKB=Q7PME7	Integrin beta	IDA	3487386	PubMed	PTHR10082:SF59	INTEGRIN BETA-NU
P05918	p38 MAPK pathway	P06031	p38alpha	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	BOVIN|Ensembl=ENSBTAG00000020742|UniProtKB=F1MBL4	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF79	FRIZZLED-9
P04393	Ras Pathway	P04570	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00322	Cytochrome C	ORYSJ|EnsemblGenome=OS05G0420600|UniProtKB=Q0DI31	Cytochrome c	ISS	1646373	PubMed	PTHR11961:SF9	CYTOCHROME C-1-RELATED
P00048	PI3 kinase pathway	P01179	PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00070	VAT2	PANTR|Ensembl=ENSPTRG00000002979|UniProtKB=H2Q2M8	Uncharacterized protein	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00029	Huntington disease	P00807	Actin	CANLF|Ensembl=ENSCAFG00000016020|UniProtKB=O18840	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00046	Oxidative stress response	P01131	MKP5	CANLF|Ensembl=ENSCAFG00000013641|UniProtKB=E2R7G4	Uncharacterized protein	ISS	10597297	PubMed	PTHR10159:SF299	DUAL SPECIFICITY PROTEIN PHOSPHATASE 10
P00053	T cell activation	P01333	cdc42	TAKRU|Ensembl=ENSTRUG00000008289|UniProtKB=H2T7U8	Uncharacterized protein	ISS	9658176	PubMed	PTHR24072:SF129	CDC42L PROTEIN
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT2G18170|UniProtKB=Q39027	Mitogen-activated protein kinase 7	IDA	12787066	PubMed	PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04397	p53 pathway by glucose deprivation	P04636	S6K	MACMU|Ensembl=ENSMMUG00000005483|UniProtKB=F7G271	Uncharacterized protein	ISS	6755374	gi	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02729	Ascorbate degradation	P02852	L-xylulose-5-phosphate-3-epimerase	AQUAE|EnsemblGenome=aq_968|UniProtKB=O67098	Ribulose-phosphate 3-epimerase	ISS			PTHR11749:SF3	RIBULOSE-PHOSPHATE 3-EPIMERASE
P02759	Pyridoxal-5-phosphate biosynthesis	P03061	Pyridoxine-5-phosphate oxidase	BOVIN|Ensembl=ENSBTAG00000012259|UniProtKB=Q5E9K3	Pyridoxine-5'-phosphate oxidase	ISS	14697241	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00015	Circadian clock system	G01501	cry	ORNAN|Ensembl=ENSOANG00000005350|UniProtKB=F6X852	Uncharacterized protein	ISS	14507900	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00006	Apoptosis signaling pathway	P00260	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04585	TRH	MOUSE|MGI=MGI=98823|UniProtKB=Q62361	Pro-thyrotropin-releasing hormone	ISS	2126343	PubMed	PTHR17530:SF2	PRO-THYROTROPIN-RELEASING HORMONE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00589	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IGI	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02747	Histidine biosynthesis	P02992	Imidazol glycerol phosphate synthase	RHOBA|EnsemblGenome=RB9372|UniProtKB=Q7ULP3	Imidazole glycerol phosphate synthase subunit HisH	ISS			PTHR42701:SF1	IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISH
P00010	B cell activation	P00376	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	3035212	PubMed	PTHR24070:SF385	GTPASE HRAS
P00005	Angiogenesis	P00204	PLD	CAEEL|WormBase=WBGene00004040|UniProtKB=G5EDU3	PhosphoLipase D	ISS			PTHR18896:SF76	PHOSPHOLIPASE D2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05918	p38 MAPK pathway	P06043	ASK1	HUMAN|HGNC=6857|UniProtKB=Q99683	Mitogen-activated protein kinase kinase kinase 5	TAS	12968034	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CANLF|Ensembl=ENSCAFG00000013755|UniProtKB=Q49LX5	Somatostatin receptor type 1	ISS	12562507	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IGI	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04397	p53 pathway by glucose deprivation	P04641	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00018	EGF receptor signaling pathway	P00558	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00053	T cell activation	P01322	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	PANTR|Ensembl=ENSPTRG00000020739|UniProtKB=H2R6U6	Solute carrier family 1 (Neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	ISS	94365697	PubMed	PTHR11958:SF69	EXCITATORY AMINO ACID TRANSPORTER 3
P00053	T cell activation	P01313	CD28	RAT|RGD=2299|UniProtKB=P31042	T-cell-specific surface glycoprotein CD28	IGI	7534617	PubMed	PTHR11494:SF7	T-CELL-SPECIFIC SURFACE GLYCOPROTEIN CD28
P00029	Huntington disease	P00778	NMDA receptor	CAEEL|WormBase=WBGene00003774|UniProtKB=G5EGQ9	NMDA class glutamate Receptor	IDA	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P05918	p38 MAPK pathway	P06021	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00024	Glycolysis	P00674	Phosphoglucose isomerase	ORYSJ|EnsemblGenome=OS03G0776000|UniProtKB=P42862	Glucose-6-phosphate isomerase, cytosolic A	ISS	96293857	PubMed	PTHR11469:SF1	GLUCOSE-6-PHOSPHATE ISOMERASE, CYTOSOLIC
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DICDI|dictyBase=DDB_G0275023|UniProtKB=Q553U6	Putative actin-22	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00047	PDGF signaling pathway	P01167	Ets	CANLF|Ensembl=ENSCAFG00000004817|UniProtKB=E2R9T4	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF156	ETS-RELATED TRANSCRIPTION FACTOR ELF-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06959	CCKR signaling map	P07168	p66 SHC1	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	RCA	8900204	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00018	EGF receptor signaling pathway	P00560	Raf-1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00558	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	RAT|RGD=3772|UniProtKB=P52631	Signal transducer and activator of transcription 3	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00539	14-3-3	MACMU|Ensembl=ENSMMUG00000013206|UniProtKB=F6XFG9	14-3-3 protein beta/alpha	ISS	91108808	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00048	PI3 kinase pathway	P01194	S6K	HUMAN|HGNC=10436|UniProtKB=P23443	Ribosomal protein S6 kinase beta-1	ISS	15116068	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	BOVIN|Ensembl=ENSBTAG00000011723|UniProtKB=E1BKL6	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=1305438|UniProtKB=Q5DWV1	Cadherin-20	ISS	8120095	PubMed	PTHR24027:SF84	CADHERIN-20
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00010	B cell activation	P00373	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	MOUSE|MGI=MGI=2446460|UniProtKB=G5E8H5	MCG118205, isoform CRA_c	IGI			PTHR12305:SF32	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE TPTE2-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00004	Alzheimer disease-presenilin pathway	P00177	Nectin 1alpha C-terminal fragment	CANLF|Ensembl=ENSCAFG00000012012|UniProtKB=F1PCB6	Uncharacterized protein	ISS	12376527	PubMed	PTHR23277:SF69	NECTIN-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IDA	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00057	Wnt signaling pathway	P01457	GBeta	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P02786	Vitamin B6 biosynthesis	P03225	1-Deoxyxylulose-5-phosphate synthase	STRCO|EnsemblGenome=CAB39701|UniProtKB=Q9X7W3	1-deoxy-D-xylulose-5-phosphate synthase 1	ISS			PTHR43322:SF6	1-DEOXY-D-XYLULOSE-5-PHOSPHATE SYNTHASE
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=1351340|UniProtKB=Q9QYS2	Metabotropic glutamate receptor 3	IDA	12488551	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00019	Endothelin signaling pathway	P00566	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	12657601	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00048	PI3 kinase pathway	P01182	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00036	Interleukin signaling pathway	P00990	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00053	T cell activation	P01332	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01411	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01443	Phospholipase C	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	DROME|FlyBase=FBgn0010399|UniProtKB=Q24418	Glutamate [NMDA] receptor subunit 1	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P02743	Formyltetrahydroformate biosynthesis	P02953	Cobalamin dependent homocysteine transmethylase	BACSU|EnsemblGenome=BSU02410|UniProtKB=O31463	Homocysteine S-methyltransferase YbgG	ISS			PTHR21091:SF123	FI01821P
P05912	Dopamine receptor mediated signaling pathway	P05955	DBH	BOVIN|Ensembl=ENSBTAG00000004508|UniProtKB=P15101	Dopamine beta-hydroxylase	ISS	90219125	PubMed	PTHR10157:SF29	DOPAMINE BETA-HYDROXYLASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MOUSE|MGI=MGI=87906|UniProtKB=P63260	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00056	VEGF signaling pathway	P01407	Erk	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01456	beta-arrestin	RAT|RGD=2157|UniProtKB=P29067	Beta-arrestin-2	IDA	4757780	gi	PTHR11792:SF20	BETA-ARRESTIN-2
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	CAEBR|Gene=CBG13013|UniProtKB=A8XGW3	Protein CBR-CDC-42	ISS			PTHR24072:SF192	CDC42 HOMOLOG
P00034	Integrin signalling pathway	P00951	Jnk	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00003	Alzheimer disease-amyloid secretase pathway	P00101	BACE-1	BOVIN|Ensembl=ENSBTAG00000019365|UniProtKB=Q2HJ40	Beta-secretase 1	ISS	10956649	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	12660731	PubMed	PTHR10048:SF14	PI-3 KINASE
P00054	Toll receptor signaling pathway	P01375	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00566	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P02742	Tetrahydrofolate biosynthesis	P02944	Phosphoribosylglycinamide formyltransferase	ARATH|TAIR=AT5G47435|UniProtKB=Q93YQ3	Formyltetrahydrofolate deformylase 1, mitochondrial	ISS			PTHR42706:SF1	FORMYLTETRAHYDROFOLATE DEFORMYLASE 1, MITOCHONDRIAL-RELATED
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00005	Angiogenesis	P00253	Axin	RAT|RGD=620859|UniProtKB=O70239	Axin-1	ISS	9554852	PubMed	PTHR10845:SF11	AXIN-1
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	PANTR|Ensembl=ENSPTRG00000017612|UniProtKB=C7G3N0	Glutamate receptor, metabotropic 6	ISS	12351712	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00892	Grb2	CAEEL|WormBase=WBGene00004774|UniProtKB=P29355	Sex muscle abnormal protein 5	ISS	8307166	PubMed	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	BOVIN|Ensembl=ENSBTAG00000039151|UniProtKB=F6R5F6	Uncharacterized protein	ISS	12441358	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00047	PDGF signaling pathway	P01159	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	RAT|RGD=2155|UniProtKB=O88656	Actin-related protein 2/3 complex subunit 1B	ISS	12963527	gi	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	RAT|RGD=619965|UniProtKB=P26769	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00049	Parkinson disease	P01227	20S proteasome	DICPU|Gene=DICPUDRAFT_52118|UniProtKB=F0Z724	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF12	PROTEASOME SUBUNIT ALPHA TYPE-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00641	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00049	Parkinson disease	P01237	Complex I	DEIRA|EnsemblGenome=DR_1501|UniProtKB=Q9RU91	NADH dehydrogenase I, E subunit	TAS	3100899	PubMed	PTHR10371:SF3	NADH DEHYDROGENASE  UBIQUINONE  FLAVOPROTEIN 2, MITOCHONDRIAL
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00011	Blood coagulation	P00451	Kininogen	MACMU|Ensembl=ENSMMUG00000003700|UniProtKB=F6SG43	Uncharacterized protein	ISS	386852	gi	PTHR13814:SF12	KININOGEN-1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	XENTR|Xenbase=XB-GENE-493937|UniProtKB=Q5M8T9	Actin, alpha 2, smooth muscle, aorta	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IGI	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	HUMAN|HGNC=1607|UniProtKB=P51684	C-C chemokine receptor type 6	IC	5478218	gi	PTHR10489:SF611	C-C CHEMOKINE RECEPTOR TYPE 6
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	RCA	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00648	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	10395542	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04393	Ras Pathway	P04572	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00034	Integrin signalling pathway	P00925	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	BOVIN|Ensembl=ENSBTAG00000002081|UniProtKB=A7YWG6	Serine/threonine-protein kinase receptor	ISS			PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P00005	Angiogenesis	P00206	Wnt	MONDO|Ensembl=ENSMODG00000012401|UniProtKB=F6PMQ6	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00018	EGF receptor signaling pathway	P00563	Gab	PANTR|Ensembl=ENSPTRG00000016471|UniProtKB=H2QQ79	GRB2-associated binding protein 1	ISS	15356145	PubMed	PTHR12156:SF18	GRB2-ASSOCIATED-BINDING PROTEIN 1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	TAKRU|Ensembl=ENSTRUG00000009851|UniProtKB=H2TJ90	Uncharacterized protein	IGI	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00054	Toll receptor signaling pathway	P01368	MKK2	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00052	TGF-beta signaling pathway	P01292	RSmads	XENTR|Xenbase=XB-GENE-1018193|UniProtKB=Q6DIS7	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	SCHPO|PomBase=SPBC32H8.12c|UniProtKB=P10989	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00048	PI3 kinase pathway	P01192	p110	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00059	p53 pathway	G04694	p110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00025	Hedgehog signaling pathway	P00682	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00577	PI3K	SCHPO|PomBase=SPAC458.05|UniProtKB=P50520	Phosphatidylinositol 3-kinase vps34	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	BOVIN|Ensembl=ENSBTAG00000026580|UniProtKB=F1MB93	Uncharacterized protein	ISS	12181435	PubMed	PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	TAS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	15621031	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	ARATH|TAIR=AT5G61210|UniProtKB=Q9S7P9	SNAP25 homologous protein SNAP33	IC			PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04393	Ras Pathway	P04542	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01443	Phospholipase C	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=97614|UniProtKB=Q8R3B1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	15611108	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00629	PP2A	ASHGO|EnsemblGenome=AGOS_AER202C|UniProtKB=Q756Q2	Serine/threonine-protein phosphatase	ISS			PTHR11668:SF24	SERINE/THREONINE-PROTEIN PHOSPHATASE 6 CATALYTIC SUBUNIT
P00019	Endothelin signaling pathway	P00591	PLCbeta	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IGI	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00049	Parkinson disease	P01242	Casein kinase I	CAEEL|WormBase=WBGene00004960|UniProtKB=Q95PZ9	Serine/threonine-protein kinase spe-6	IDA	10617630	PubMed	PTHR11909:SF72	SERINE/THREONINE-PROTEIN KINASE SPE-6
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CAEEL|WormBase=WBGene00001680|UniProtKB=Q20636	Guanine nucleotide-binding protein subunit beta-2	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00053	T cell activation	P01307	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	YEAST|SGD=S000006153|UniProtKB=P32867	Protein SSO1	IC			PTHR19957:SF41	SYNTAXIN-1A
P00005	Angiogenesis	P00205	GAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	2574500	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00013	Cell cycle	P00484	Cyclin D	MACMU|Ensembl=ENSMMUG00000004419|UniProtKB=F7GU42	G1/S-specific cyclin-D3 isoform 2	ISS	12884287	PubMed	PTHR10177:SF65	G1/S-SPECIFIC CYCLIN-D3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04633	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06850	PKCs(3)	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	RCA	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MOUSE|MGI=MGI=99677|UniProtKB=O88444	Adenylate cyclase type 1	ISS	2491850	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	MACMU|Ensembl=ENSMMUG00000014817|UniProtKB=F6VXD8	Uncharacterized protein	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05918	p38 MAPK pathway	P06029	p38beta	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IGI	14526383	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00048	PI3 kinase pathway	P01182	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P04393	Ras Pathway	P04567	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IDA	96009592	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	DROME|FlyBase=FBgn0087012|UniProtKB=Q8IPN2	5-hydroxytryptamine (Serotonin) receptor 2A, isoform B	ISS	8143856	PubMed	PTHR24247:SF125	5-HYDROXYTRYPTAMINE  SEROTONIN  RECEPTOR 2A, ISOFORM B
P00025	Hedgehog signaling pathway	P00687	Cubitus interruptus repressor	DROME|FlyBase=FBgn0004859|UniProtKB=P19538	Transcriptional activator cubitus interruptus	IDA	9215627	PubMed	PTHR19818:SF124	TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS
P04397	p53 pathway by glucose deprivation	P04641	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000011761|UniProtKB=F1MDE1	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P04398	p53 pathway feedback loops 2	P04651	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	IDA	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00010	B cell activation	P00379	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	SCHPO|PomBase=SPBC32H8.07|UniProtKB=Q10282	Guanine nucleotide-binding protein subunit beta	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	DICDI|dictyBase=DDB_G0274569|UniProtKB=Q03101	Adenylate cyclase, germination specific	IGI	92233467	PubMed	PTHR11920:SF442	ADENYLATE CYCLASE, GERMINATION SPECIFIC
P00010	B cell activation	P00384	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IDA	12810719	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00022	General transcription by RNA polymerase I	P00652	RNA Polymerase I  Complex	YEAST|SGD=S000001608|UniProtKB=P36070	RNA polymerase I-specific transcription initiation factor RRN3	ISS			PTHR12790:SF0	RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN3-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	1650351	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00030	Hypoxia response via HIF activation	P00818	HIF-1alpha	MACMU|Ensembl=ENSMMUG00000021002|UniProtKB=F7HKJ2	Uncharacterized protein	ISS	14526383	PubMed	PTHR23043:SF7	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA
P00006	Apoptosis signaling pathway	P00278	Bag	MACMU|Ensembl=ENSMMUG00000000798|UniProtKB=F6R2V4	BAG family molecular chaperone regulator 3	ISS			PTHR12329:SF12	BAG FAMILY MOLECULAR CHAPERONE REGULATOR 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00321	HSP70	DANRE|ZFIN=ZDB-GENE-050321-1|UniProtKB=B0S610	Novel protein similar to heat shock cognate 70-kd protein	ISS	12150907	PubMed	PTHR19375:SF256	HSP70 PROTEIN-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	BOVIN|Ensembl=ENSBTAG00000007882|UniProtKB=G3X7Z2	Uncharacterized protein	ISS	15079861	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P02743	Formyltetrahydroformate biosynthesis	P02952	Methylene tetrahydrofolate dehydrogenase	PYRAE|EnsemblGenome=PAE0220|UniProtKB=Q8ZZK1	Bifunctional protein FolD	ISS			PTHR10025:SF46	BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, MITOCHONDRIAL
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00006	Apoptosis signaling pathway	P00310	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00589	Akt	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	IGI	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00981	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00004	Alzheimer disease-presenilin pathway	P00121	CD44 intracellular fragment	MACMU|Ensembl=ENSMMUG00000004327|UniProtKB=F6ZDZ8	Uncharacterized protein	ISS	12223485	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00048	PI3 kinase pathway	P01177	P110ACT	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	15531926	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	MOUSE|MGI=MGI=1298218|UniProtKB=O88572	Low-density lipoprotein receptor-related protein 6	IDA	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00004	Alzheimer disease-presenilin pathway	P00113	Erb-B4 transmembrane fragment	HUMAN|HGNC=3432|UniProtKB=Q15303	Receptor tyrosine-protein kinase erbB-4	IDA	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00056	VEGF signaling pathway	P01407	Erk	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	IDA	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00057	Wnt signaling pathway	P01465	Ggamma	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00019	Endothelin signaling pathway	P00574	Big ET1-4	PANTR|Ensembl=ENSPTRG00000000602|UniProtKB=H2PYT1	Uncharacterized protein	ISS			PTHR13874:SF9	ENDOTHELIN-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00702	CPB	XENTR|Xenbase=XB-GENE-945015|UniProtKB=F6QA46	Uncharacterized protein	ISS			PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00049	Parkinson disease	P01211	ERK	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	IDA	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	IDA	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00054	Toll receptor signaling pathway	P01338	IkappaB	HUMAN|HGNC=7799|UniProtKB=O00221	NF-kappa-B inhibitor epsilon	ISS			PTHR24118:SF37	NF-KAPPA-B INHIBITOR EPSILON
P00053	T cell activation	P01336	Jnk	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=2685045|UniProtKB=E9QAN8	Protein Pik3c2b	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00020	FAS signaling pathway	P00604	Pro-Caspase8	MOUSE|MGI=MGI=1261423|UniProtKB=O89110	Caspase-8	IGI	11788820	PubMed	PTHR10454:SF162	CASPASE-8
P00005	Angiogenesis	P00251	cPLA2	MACMU|Ensembl=ENSMMUG00000021423|UniProtKB=F7EEZ1	Phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00053	T cell activation	P01332	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IDA	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00015	Circadian clock system	G01501	cry	MOUSE|MGI=MGI=1270859|UniProtKB=Q9R194	Cryptochrome-2	IEP	10217146	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00047	PDGF signaling pathway	P01142	p90RSK	MACMU|Ensembl=ENSMMUG00000022111|UniProtKB=F7H7W3	Ribosomal protein S6 kinase	ISS	12213813	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00048	PI3 kinase pathway	P01188	Gbetagamma	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04397	p53 pathway by glucose deprivation	P04641	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00030	Hypoxia response via HIF activation	P00823	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	XENTR|Xenbase=XB-GENE-491938|UniProtKB=Q6DIV8	Actin, alpha 1, skeletal muscle	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00047	PDGF signaling pathway	P01160	IP3 receptor	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	TAS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00048	PI3 kinase pathway	P01179	PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	CHICK|Gene=PSEN2|UniProtKB=Q90X07	Presenilin-2	IDA	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	RAT|RGD=619751|UniProtKB=O88302	Guanine nucleotide-binding protein subunit alpha-15	ISS	8838318	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P00021	FGF signaling pathway	P00633	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00012	Cadherin signaling pathway	P00470	F-actin	MOUSE|MGI=MGI=87905|UniProtKB=P68033	Actin, alpha cardiac muscle 1	IC	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00006	Apoptosis signaling pathway	P00310	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IDA	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P04393	Ras Pathway	P04555	PDK	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	IDA	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	PANTR|Ensembl=ENSPTRG00000004326|UniProtKB=H2Q4V0	Uncharacterized protein	ISS			PTHR44107:SF3	DOWN SYNDROME CELL ADHESION MOLECULE-LIKE PROTEIN 1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00005	Angiogenesis	P00203	Erk	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00057	Wnt signaling pathway	P01437	TCF	RAT|RGD=620241|UniProtKB=Q9QXN1	Lymphoid enhancer-binding factor 1	IDA	11266476	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05734	Synaptic vesicle trafficking	P05777	Synaptophysin	MACMU|Ensembl=ENSMMUG00000023025|UniProtKB=F6VGB3	Synaptophysin	ISS	313475	OMIM	PTHR10306:SF10	SYNAPTOPHYSIN
P00036	Interleukin signaling pathway	P00970	Interleukin	BOVIN|Gene=IL2|UniProtKB=P05016	Interleukin-2	IDA	3486415	PubMed	PTHR45426:SF1	INTERLEUKIN-2
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	RAT|RGD=3425|UniProtKB=P97887	Presenilin-1	IDA	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P02738	De novo purine biosynthesis	P02898	Phosphoribosylformylglycinamide  synthase	SYNY3|EnsemblGenome=BAA10599|UniProtKB=Q55843	Phosphoribosylformylglycinamidine synthase subunit PurQ	ISS			PTHR10099:SF1	PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	IC	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00562	p38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	IGI	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00020	FAS signaling pathway	P00615	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01173	STAT	MOUSE|MGI=MGI=103034|UniProtKB=P52633	Signal transducer and transcription activator 6	ISS	14598258	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00036	Interleukin signaling pathway	P00981	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P02772	Pyruvate metabolism	P03140	Pyruvate Carboxylase	RAT|RGD=3262|UniProtKB=P52873	Pyruvate carboxylase, mitochondrial	TAS	12112657	PubMed	PTHR43778:SF2	PYRUVATE CARBOXYLASE, MITOCHONDRIAL
P05734	Synaptic vesicle trafficking	P05779	Synaptobrevin	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	RCA	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00029	Huntington disease	P00780	Microtubule	PHYPA|Gene=PHYPADRAFT_121199|UniProtKB=A9RY37	Predicted protein	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00859	NFkappaB	RAT|RGD=1307189|UniProtKB=Q5U2Z4	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	ISS	20151924	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00190	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	2842690	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P02738	De novo purine biosynthesis	P02893	ATP reductase	BACTN|EnsemblGenome=BT_1998|UniProtKB=Q8A688	Anaerobic ribonucleoside-triphosphate reductase	ISS			PTHR21075:SF0	ANAEROBIC RIBONUCLEOSIDE-TRIPHOSPHATE REDUCTASE
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00624	14-3-3	CANLF|Ensembl=ENSCAFG00000003386|UniProtKB=F6Y478	Uncharacterized protein	ISS	7603573	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00010	B cell activation	P00371	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	NAS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MACMU|Ensembl=ENSMMUG00000004886|UniProtKB=F7AGT9	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00012	Cadherin signaling pathway	P00470	F-actin	DANRE|ZFIN=ZDB-GENE-050410-4|UniProtKB=Q56A35	Actin-related protein 2-B	ISS	11889126	PubMed	PTHR11937:SF149	ACTIN-RELATED PROTEIN 2-A-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04427	5HT4 Receptor	MACMU|Ensembl=ENSMMUG00000016913|UniProtKB=F7GIV0	Uncharacterized protein	ISS	12898568	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P00018	EGF receptor signaling pathway	P00545	JNK1-3	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00019	Endothelin signaling pathway	P00591	PLCbeta	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IGI	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=97614|UniProtKB=Q8R3B1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	7822322	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00036	Interleukin signaling pathway	P00986	eNOS	CANLF|Gene=NOS3|UniProtKB=Q9TUX8	Nitric oxide synthase, endothelial	ISS	22462730	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	ISS	22084520	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00046	Oxidative stress response	P01131	MKP5	PANTR|Ensembl=ENSPTRG00000017654|UniProtKB=H2RF15	Uncharacterized protein	ISS			PTHR10159:SF29	DUAL SPECIFICITY PROTEIN PHOSPHATASE 22
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05916	Opioid prodynorphin pathway	P05999	provasopressin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00021	FGF signaling pathway	P00636	FGFR1-4	HUMAN|HGNC=3690|UniProtKB=P22607	Fibroblast growth factor receptor 3	IGI	14520460	PubMed	PTHR24416:SF505	FIBROBLAST GROWTH FACTOR RECEPTOR 3
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00045	Notch signaling pathway	P01115	Neurotic	RAT|RGD=1303096|UniProtKB=Q6EV76	Alpha-(1,6)-fucosyltransferase	ISS			PTHR13132:SF29	ALPHA- 1,6 -FUCOSYLTRANSFERASE
P00009	Axon guidance mediated by netrin	P00366	Rac	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS	12874273	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00056	VEGF signaling pathway	P01403	VEGFR-2	CANLF|Ensembl=ENSCAFG00000002079|UniProtKB=Q2XPT7	Uncharacterized protein	ISS	11824379	PubMed	PTHR24416:SF45	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2
P04396	Vitamin D metabolism and pathway	P04603	1alpha-Hydroxylase	BOVIN|Ensembl=ENSBTAG00000016906|UniProtKB=E1BN35	Uncharacterized protein	ISS	11013342	PubMed	PTHR24291:SF3	25-HYDROXYVITAMIN D-1 ALPHA HYDROXYLASE, MITOCHONDRIAL
P00021	FGF signaling pathway	P00633	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	PANTR|Ensembl=ENSPTRG00000003699|UniProtKB=H2Q3R5	Syntaxin 3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00014	Cholesterol biosynthesis	P00499	Farnesyl-diphosphate farnesyltransferase	RAT|RGD=61834|UniProtKB=Q02769	Squalene synthase	ISS			PTHR11626:SF2	SQUALENE SYNTHASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00018	EGF receptor signaling pathway	P00564	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	10540223	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	MOUSE|MGI=MGI=87917|UniProtKB=Q01341	Adenylate cyclase type 6	IC	92357702	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00021	FGF signaling pathway	P00645	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	10802295	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IGI	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	13430383	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000014576|UniProtKB=H2QLZ9	Uncharacterized protein	ISS	11431030	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06829	Prep1	MOUSE|MGI=MGI=1201409|UniProtKB=O70477	Homeobox protein PKNOX1	RCA			PTHR11850:SF80	HOMEOBOX PROTEIN PKNOX1
P00053	T cell activation	P01333	cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00053	T cell activation	P01322	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	BOVIN|Gene=ACTR2|UniProtKB=A7MB62	Actin-related protein 2	ISS	11889126	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	PANTR|Ensembl=ENSPTRG00000011049|UniProtKB=H2QGF9	Glycogen synthase kinase 3 alpha	ISS	2164470	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00030	Hypoxia response via HIF activation	P00819	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P06587	Nicotine pharmacodynamics pathway	P06604	SLC18A2	PANTR|Ensembl=ENSPTRG00000002979|UniProtKB=H2Q2M8	Uncharacterized protein	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P02727	Androgen/estrogene/progesterone biosynthesis	P02829	Cholesterol acyltransferase	CANLF|Ensembl=ENSCAFG00000013894|UniProtKB=F1PUL0	O-acyltransferase	ISS	9756918	PubMed	PTHR10408:SF6	STEROL O-ACYLTRANSFERASE 1
P00012	Cadherin signaling pathway	P00474	Wnt	BOVIN|Ensembl=ENSBTAG00000008097|UniProtKB=A4D7S0	Protein Wnt-2	ISS	11266476	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MACMU|Ensembl=ENSMMUG00000012054|UniProtKB=F6TII3	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00645	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00006	Apoptosis signaling pathway	P00260	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	PANTR|Ensembl=ENSPTRG00000008766|UniProtKB=H2QC97	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF504	MYOSIN-13
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05949	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12748278	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04395	Vasopressin synthesis	P04594	Neurophysin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00053	T cell activation	P01336	Jnk	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	RAT|RGD=2958|UniProtKB=P63251	G protein-activated inward rectifier potassium channel 1	ISS	12374786	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00021	FGF signaling pathway	P00633	Ras	DICPU|Gene=DICPUDRAFT_91367|UniProtKB=F0ZB76	Putative uncharacterized protein rasD	ISS	85024887	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00035	Interferon-gamma signaling pathway	P00954	Interferongamma	MACMU|Ensembl=ENSMMUG00000019225|UniProtKB=P63310	Interferon gamma	TAS	11175845	PubMed	PTHR11419:SF0	INTERFERON GAMMA
P00036	Interleukin signaling pathway	P00983	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04395	Vasopressin synthesis	P04589	Signal Peptidase	BOVIN|Ensembl=ENSBTAG00000004747|UniProtKB=Q3T134	Signal peptidase complex subunit 1	ISS			PTHR13202:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 1
P00018	EGF receptor signaling pathway	P00547	PP2A	MONDO|Ensembl=ENSMODG00000014177|UniProtKB=F6U7A6	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00790	beta-Tubulin	HUMAN|HGNC=20774|UniProtKB=P04350	Tubulin beta-4A chain	TAS	9454836	PubMed	PTHR11588:SF253	TUBULIN BETA-4A CHAIN
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00034	Integrin signalling pathway	P00925	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IDA	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00053	T cell activation	P01307	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	IPI	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00056	VEGF signaling pathway	P01411	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P00020	FAS signaling pathway	P00615	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00046	Oxidative stress response	P01135	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	IXOSC|EnsemblGenome=ISCW009711|UniProtKB=B7Q3T6	THO complex subunit, putative	ISS	9740024	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	BOVIN|Ensembl=ENSBTAG00000002015|UniProtKB=G5E5T2	Uncharacterized protein	ISS	15632195	PubMed	PTHR24351:SF98	RIBOSOMAL PROTEIN S6 KINASE ALPHA-6
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_115291|UniProtKB=C3ZMR2	Putative uncharacterized protein	ISS			PTHR11937:SF359	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	TAS	9836512	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04548	ATF2	CANLF|Ensembl=ENSCAFG00000013332|UniProtKB=F1PCQ4	Uncharacterized protein	ISS	7875593	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P06959	CCKR signaling map	P07057	B-Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	RCA	15520807	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00038	JAK/STAT signaling pathway	P01027	STAT	MOUSE|MGI=MGI=103038|UniProtKB=P42227	Signal transducer and activator of transcription 3	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IGI	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04393	Ras Pathway	P04546	GSK3	PANTR|Ensembl=ENSPTRG00000011049|UniProtKB=H2QGF9	Glycogen synthase kinase 3 alpha	ISS	183955	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	ARATH|TAIR=AT3G47220|UniProtKB=Q6NMA7	Phosphoinositide phospholipase C 9	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P05915	Opioid proenkephalin pathway	P05993	AC	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02736	Coenzyme A biosynthesis	P02885	Pantothenate kinase	MACMU|Ensembl=ENSMMUG00000014686|UniProtKB=F7GTZ5	Pantothenate kinase 4	ISS			PTHR12280:SF20	PANTOTHENATE KINASE 4
P05916	Opioid prodynorphin pathway	P06002	G-protein	YEAST|SGD=S000005738|UniProtKB=P18851	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00057	Wnt signaling pathway	P01429	Axin	XENTR|Xenbase=XB-GENE-486781|UniProtKB=F6XWP7	Uncharacterized protein	ISS	12356903	PubMed	PTHR10845:SF11	AXIN-1
P00054	Toll receptor signaling pathway	P01375	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02738	De novo purine biosynthesis	P02905	Amidophosphoribosyl transferase	CAEEL|WormBase=WBGene00011407|UniProtKB=Q22134	Amidophosphoribosyltransferase	ISS			PTHR11907:SF18	AMIDOPHOSPHORIBOSYLTRANSFERASE
P00020	FAS signaling pathway	P00615	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	CHICK|Ensembl=ENSGALG00000028612|UniProtKB=F1P3X1	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF728	MYOSIN HEAVY CHAIN, SKELETAL MUSCLE, ADULT
P00030	Hypoxia response via HIF activation	P00819	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01279	Smurfs	ORNAN|Ensembl=ENSOANG00000007719|UniProtKB=F6TJ28	Uncharacterized protein (Fragment)	ISS	11252892	PubMed	PTHR11254:SF293	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P00020	FAS signaling pathway	P00603	Pro-Caspase9	HUMAN|HGNC=1511|UniProtKB=P55211	Caspase-9	IGI	11440972	PubMed	PTHR10454:SF157	CASPASE-9
P06587	Nicotine pharmacodynamics pathway	P06590	GNG	HUMAN|HGNC=4404|UniProtKB=P59768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00021	FGF signaling pathway	P00624	14-3-3	ARATH|TAIR=AT1G34760|UniProtKB=Q9S9Z8	14-3-3-like protein GF14 omicron	ISS	10407019	PubMed	PTHR18860:SF32	14-3-3 FAMILY PROTEIN-RELATED
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TRIVA|Gene=TVAG_337240|UniProtKB=P90623	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	TAS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00049	Parkinson disease	P01215	Syntaxin	RAT|RGD=619747|UniProtKB=O70257	Syntaxin-7	IPI	14570579	PubMed	PTHR19957:SF90	SYNTAXIN-7
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05916	Opioid prodynorphin pathway	P06003	dynorphin	HUMAN|HGNC=8820|UniProtKB=P01213	Proenkephalin-B	RCA	131330	OMIM	PTHR11438:SF4	PROENKEPHALIN-B
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	CANLF|Ensembl=ENSCAFG00000011252|UniProtKB=F1Q334	Uncharacterized protein	ISS	11266476	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00059	p53 pathway	P01486	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00566	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	DANRE|ZFIN=ZDB-GENE-991119-4|UniProtKB=Q9W6T7	Presenilin-1	TAS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P04398	p53 pathway feedback loops 2	P04665	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00585	ECE1-3	CANLF|Ensembl=ENSCAFG00000014920|UniProtKB=F1PK66	Uncharacterized protein	ISS	8034569	PubMed	PTHR11733:SF130	ENDOTHELIN-CONVERTING ENZYME 1
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	CANLF|Gene=PSEN1|UniProtKB=Q6RH31	Presenilin-1	ISS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00019	Endothelin signaling pathway	P00568	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IGI	10644715	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	HUMAN|HGNC=4581|UniProtKB=Q13003	Glutamate receptor ionotropic, kainate 3	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	PANTR|Ensembl=ENSPTRG00000009200|UniProtKB=H2QD20	Signal transducer and activator of transcription	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P05731	GABA-B receptor II signaling	P05754	Ggamma	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00023	General transcription regulation	P00664	TFIIH complex	RAT|RGD=1303309|UniProtKB=Q6MG20	General transcription factor II H, polypeptide 4	ISS			PTHR13152:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4
P00012	Cadherin signaling pathway	P00470	F-actin	PANTR|Ensembl=ENSPTRG00000011990|UniProtKB=H2QHZ9	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P02738	De novo purine biosynthesis	P02909	GDP reductase	FUSNN|EnsemblGenome=FN0102|UniProtKB=Q8RH18	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00052	TGF-beta signaling pathway	P01284	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00009	Axon guidance mediated by netrin	P00363	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	NEUCR|EnsemblGenome=EFNCRG00000003957|UniProtKB=V5ILY7	Protein kinase gsk3	ISS	12615961	PubMed	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	ANOGA|EnsemblGenome=AGAP010172|UniProtKB=Q7PD38	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	11035810	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	RAT|RGD=621109|UniProtKB=O88321	Antisecretory factor	ISS	10505793	PubMed	PTHR10223:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4
P00048	PI3 kinase pathway	P01181	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IPI	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	PANTR|Ensembl=ENSPTRG00000001389|UniProtKB=H2Q056	Uncharacterized protein	ISS	15155845	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00054	Toll receptor signaling pathway	P01352	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02788	Xanthine and guanine salvage pathway	P03247	Xanthine phosphoribosyl transferase	CANLF|Gene=HPRT1|UniProtKB=Q6WIT9	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF6	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE
P02763	Peptidoglycan biosynthesis	P03088	UDP-N-acetylmuramate dehydrogenase	FUSNN|EnsemblGenome=FN1455|UniProtKB=Q8RDQ3	UDP-N-acetylenolpyruvoylglucosamine reductase	ISS			PTHR21071:SF4	UDP-N-ACETYLENOLPYRUVOYLGLUCOSAMINE REDUCTASE
P00034	Integrin signalling pathway	P00951	Jnk	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00019	Endothelin signaling pathway	P00567	PKG	CHICK|Ensembl=ENSGALG00000003805|UniProtKB=F1NE85	cGMP-dependent protein kinase	ISS	12855709	PubMed	PTHR24353:SF68	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00223	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05915	Opioid proenkephalin pathway	P05994	G-protein	HUMAN|HGNC=4404|UniProtKB=P59768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00013	Cell cycle	P00480	Proteasome	STRPU|EnsemblGenome=SPU_019233|UniProtKB=W4YTT9	Uncharacterized protein	ISS	9727008	PubMed	PTHR10410:SF5	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 14
P00057	Wnt signaling pathway	P01457	GBeta	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	RAT|RGD=69319|UniProtKB=P54313	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEEL|WormBase=WBGene00004033|UniProtKB=P90980	Protein kinase C-like 2	IC	3755548	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00053	T cell activation	P01336	Jnk	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00019	Endothelin signaling pathway	P00566	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IGI	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00780	Microtubule	BRAFL|Gene=BRAFLDRAFT_60807|UniProtKB=C3Y2F5	Putative uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00059	p53 pathway	P01485	p53	MACMU|Ensembl=ENSMMUG00000008639|UniProtKB=P56424	Cellular tumor antigen p53	TAS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1693|UniProtKB=Q6P967	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	BOVIN|Ensembl=ENSBTAG00000003512|UniProtKB=E1BPX8	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF358	MYOSIN-7B
P04393	Ras Pathway	P04542	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00587	Raf-1	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS			PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00922	Collagen	MOUSE|MGI=MGI=104687|UniProtKB=Q9QZR9	Collagen alpha-4(IV) chain	IDA	10778855	PubMed	PTHR24023:SF714	COLLAGEN ALPHA-4 IV  CHAIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000017612|UniProtKB=C7G3N0	Glutamate receptor, metabotropic 6	ISS	11431030	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00021	FGF signaling pathway	P00642	MEK1-2	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02763	Peptidoglycan biosynthesis	P03084	UDP-N-acetylmuramoylalanyl-D-glutamate 2,6-diaminopimelate ligase	DEIRA|EnsemblGenome=DR_0297|UniProtKB=Q9RXL3	UDP-N-acetylmuramyl-tripeptide synthetase	ISS			PTHR23135:SF4	UDP-N-ACETYLMUAMOYLALANYL-D-GLUTAMATE-2,6-DIAMINOPIMELATE LIGASE-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	9199552	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00013	Cell cycle	P00483	Cyclin E	MACMU|Ensembl=ENSMMUG00000020668|UniProtKB=F7BEI4	Uncharacterized protein	ISS	12729791	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00034	Integrin signalling pathway	P00944	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g169611|UniProtKB=A7SEB1	Predicted protein	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	ISS	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P00035	Interferon-gamma signaling pathway	P00960	PTP	TAKRU|Ensembl=ENSTRUG00000018529|UniProtKB=H2VDZ2	Tyrosine-protein phosphatase non-receptor type	ISS	14525967	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00057	Wnt signaling pathway	P01429	Axin	CANLF|Ensembl=ENSCAFG00000011236|UniProtKB=E2R9F8	Uncharacterized protein	ISS	9554852	PubMed	PTHR10845:SF103	AXIN-2
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00034	Integrin signalling pathway	P00948	Rho	RAT|RGD=1304965|UniProtKB=A0A0G2K6E0	Protein Rhoc	ISS	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P02785	Valine biosynthesis	P03216	Acetolactate synthase	CRYNJ|EnsemblGenome=CNA02570|UniProtKB=Q5KPJ5	Acetolactate synthase, mitochondrial	ISS			PTHR18968:SF13	ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL
P00029	Huntington disease	P00771	Sin3A	BOVIN|Ensembl=ENSBTAG00000009985|UniProtKB=F1MTR3	Uncharacterized protein	ISS	10441327	PubMed	PTHR12346:SF2	PAIRED AMPHIPATHIC HELIX PROTEIN SIN3A
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	TAS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05726	2-arachidonoylglycerol biosynthesis	P05736	DGL	HUMAN|HGNC=6677|UniProtKB=P06858	Lipoprotein lipase	TAS			PTHR11610:SF3	LIPOPROTEIN LIPASE
P00012	Cadherin signaling pathway	P00474	Wnt	RAT|RGD=1308057|UniProtKB=F1M077	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04580	TRH Receptor	MACMU|Ensembl=ENSMMUG00000008734|UniProtKB=F7DWM0	Thyrotropin-releasing hormone receptor	ISS	14599121	PubMed	PTHR24243:SF115	THYROTROPIN-RELEASING HORMONE RECEPTOR
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IGI	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00011	Blood coagulation	P00443	Fibrin polymer cross-linked	HUMAN|HGNC=3662|UniProtKB=P02675	Fibrinogen beta chain	ISS	6575700	PubMed	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00006	Apoptosis signaling pathway	P00302	ATF	XENTR|Xenbase=XB-GENE-945015|UniProtKB=F6QA46	Uncharacterized protein	ISS	11390664	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00054	Toll receptor signaling pathway	P01352	p38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00038	JAK/STAT signaling pathway	P01034	Jak	MOUSE|MGI=MGI=96628|UniProtKB=P52332	Tyrosine-protein kinase JAK1	ISS	9637709	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	89186920	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000022936|UniProtKB=F6U709	Uncharacterized protein	ISS	11861492	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MONDO|Ensembl=ENSMODG00000019177|UniProtKB=F7AX85	Uncharacterized protein (Fragment)	ISS			PTHR13140:SF417	UNCONVENTIONAL MYOSIN-ID
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02724	Alanine biosynthesis	P02815	Branched chain amino acid aminotransferase	ARATH|TAIR=AT3G49680|UniProtKB=Q9M401	Branched-chain-amino-acid aminotransferase 3, chloroplastic	ISS			PTHR42825:SF2	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 3, CHLOROPLASTIC
P00021	FGF signaling pathway	P00633	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00015	Circadian clock system	G01499	per	HUMAN|HGNC=8847|UniProtKB=P56645	Period circadian protein homolog 3	ISS	15700718	PubMed	PTHR11269:SF13	PERIOD CIRCADIAN PROTEIN HOMOLOG 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	15572354	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00053	T cell activation	P01307	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P02748	Isoleucine biosynthesis	P02994	Branched chain amino acid aminotransferase	BOVIN|Ensembl=ENSBTAG00000013825|UniProtKB=A4IFQ7	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF51	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, CYTOSOLIC
P00005	Angiogenesis	P00212	EphR	CHICK|Gene=EPHA3|UniProtKB=P29318	Ephrin type-A receptor 3	ISS			PTHR24416:SF18	EPHRIN TYPE-A RECEPTOR 3
P05917	Opioid proopiomelanocortin pathway	P06011	AC	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00047	PDGF signaling pathway	P01174	Rho	MONDO|Ensembl=ENSMODG00000001993|UniProtKB=F6RHV4	Uncharacterized protein	ISS			PTHR14166:SF6	SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 2-RELATED
P00029	Huntington disease	P00780	Microtubule	MACMU|Ensembl=ENSMMUG00000008877|UniProtKB=F7DTM8	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01306	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01171	PLCgamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IPI	98189216	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000007084|UniProtKB=H2Q9G5	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00006	Apoptosis signaling pathway	P00318	PKCs	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IC	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00048	PI3 kinase pathway	P01188	Gbetagamma	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	BOVIN|Ensembl=ENSBTAG00000006495|UniProtKB=P11017	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	MOUSE|MGI=MGI=95809|UniProtKB=P23819	Glutamate receptor 2	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P02785	Valine biosynthesis	P03216	Acetolactate synthase	PSEAE|EnsemblGenome=PA4696|UniProtKB=Q9HVA0	Acetolactate synthase	ISS			PTHR18968:SF116	ACETOLACTATE SYNTHASE ISOZYME 3 LARGE SUBUNIT
P00057	Wnt signaling pathway	P01451	Galpha	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	IDA	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	RAT|RGD=1311192|UniProtKB=A0A0G2K3R1	Protein Map3k4	ISS	11730323	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00019	Endothelin signaling pathway	P00583	cPLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00011	Blood coagulation	P00440	ATIII	BOVIN|Gene=SERPINC1|UniProtKB=P41361	Antithrombin-III	ISS	1082955	gi	PTHR11461:SF53	ANTITHROMBIN-III
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9405|UniProtKB=Q16512	Serine/threonine-protein kinase N1	IC	10644715	PubMed	PTHR24356:SF246	SERINE/THREONINE-PROTEIN KINASE N1
P00060	Ubiquitin proteasome pathway	P01491	E2	MACMU|Ensembl=ENSMMUG00000018994|UniProtKB=F6XWT0	Uncharacterized protein	ISS	10888878	PubMed	PTHR24068:SF67	UBIQUITIN-CONJUGATING ENZYME E2 L3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	10747026	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	XENTR|Xenbase=XB-GENE-491618|UniProtKB=Q6P378	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00009	Axon guidance mediated by netrin	P00363	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00053	T cell activation	P01306	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	RAT|RGD=620761|UniProtKB=Q9R172	Neurogenic locus notch homolog protein 3	IDA	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00052	TGF-beta signaling pathway	P01284	JNK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	TAS	11707292	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02752	Mannose metabolism	P03018	Mannose 1-P guanylyl transferase	PANTR|Ensembl=ENSPTRG00000012959|UniProtKB=H2QJH1	GDP-mannose pyrophosphorylase A	ISS	12477932	PubMed	PTHR22572:SF104	MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE ALPHA
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P06664	Gonadotropin-releasing hormone receptor pathway	P06727	GnRHR	MOUSE|MGI=MGI=95790|UniProtKB=Q01776	Gonadotropin-releasing hormone receptor	RCA	1333052	PubMed	PTHR24241:SF22	GONADOTROPIN-RELEASING HORMONE RECEPTOR
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	TAS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00624	14-3-3	DANRE|ZFIN=ZDB-GENE-011115-1|UniProtKB=Q6PC29	14-3-3 protein gamma-1	ISS	91108808	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	HUMAN|HGNC=2514|UniProtKB=P35222	Catenin beta-1	TAS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CANLF|Ensembl=ENSCAFG00000005662|UniProtKB=E2R907	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00056	VEGF signaling pathway	P01417	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00047	PDGF signaling pathway	P01153	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00034	Integrin signalling pathway	P00931	Integrin beta	CHICK|Ensembl=ENSGALG00000000379|UniProtKB=Q92071	Integrin beta	IDA	631019	gi	PTHR10082:SF25	INTEGRIN BETA-3
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04398	p53 pathway feedback loops 2	P04657	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00049	Parkinson disease	P01211	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00780	Microtubule	ARATH|TAIR=AT4G20890|UniProtKB=P29517	Tubulin beta-9 chain	IDA	12932731	PubMed	PTHR11588:SF245	TUBULIN BETA-4 CHAIN-RELATED
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	CANLF|Ensembl=ENSCAFG00000007882|UniProtKB=E2QX69	Uncharacterized protein	ISS			PTHR42884:SF14	NEUROENDOCRINE CONVERTASE 1
P00046	Oxidative stress response	P01129	JNK1/2	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00046	Oxidative stress response	P01121	MKK3/6	RAT|RGD=1306620|UniProtKB=B1H230	Map2k3 protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00029	Huntington disease	P00775	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00006	Apoptosis signaling pathway	P00269	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	4506785	gi	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00030	Hypoxia response via HIF activation	P00819	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IC	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00053	T cell activation	P01322	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	DROME|FlyBase=FBgn0010453|UniProtKB=P40589	Protein Wnt-4	TAS	11266476	PubMed	PTHR12027:SF102	PROTEIN WNT-4
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	CANAL|EnsemblGenome=CaO19.1760|UniProtKB=Q59XU5	Ras-like protein 1	ISS	10515923	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00019	Endothelin signaling pathway	P00587	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01171	PLCgamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	HUMAN|HGNC=4041|UniProtKB=Q9NPG1	Frizzled-3	TAS	8717036	PubMed	PTHR11309:SF22	FRIZZLED-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IDA	91298951	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DROME|FlyBase=FBgn0004623|UniProtKB=P29829	Guanine nucleotide-binding protein subunit beta-2	IC			PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00046	Oxidative stress response	P01134	cPLA2	MONDO|Ensembl=ENSMODG00000011791|UniProtKB=F7CBU9	Phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02776	Serine glycine biosynthesis	P03157	Phosphoserine aminotransferase	ANOGA|EnsemblGenome=AGAP004598|UniProtKB=Q5TRW7	Phosphoserine aminotransferase	ISS			PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00021	FGF signaling pathway	P00648	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00018	EGF receptor signaling pathway	P00557	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00020	FAS signaling pathway	P00594	Caspase8	PANTR|Ensembl=ENSPTRG00000012798|UniProtKB=H2R695	CASP8 and FADD-like apoptosis regulator	ISS	9228018	PubMed	PTHR10454:SF8	CASP8 AND FADD-LIKE APOPTOSIS REGULATOR
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00029	Huntington disease	P00778	NMDA receptor	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	IDA	11319238	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00048	PI3 kinase pathway	P01179	PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00017	DNA replication	P00527	Histones	PUCGT|EnsemblGenome=PGTG_11296|UniProtKB=E3KLF2	Histone H3	ISS	12413958	PubMed	PTHR11426:SF169	HISTONE H3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CAEEL|WormBase=WBGene00000066|UniProtKB=P10986	Actin-4	IC	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00011	Blood coagulation	P00412	PS	MACMU|Gene=PROS1|UniProtKB=Q28520	Vitamin K-dependent protein S (Fragment)	ISS	87092407	PubMed	PTHR24040:SF0	VITAMIN K-DEPENDENT PROTEIN S
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IDA	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	CANLF|Ensembl=ENSCAFG00000005526|UniProtKB=E2RKR0	Uncharacterized protein	ISS	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	HUMAN|HGNC=10618|UniProtKB=P13500	C-C motif chemokine 2	ISS			PTHR12015:SF98	C-C MOTIF CHEMOKINE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MOUSE|MGI=MGI=102705|UniProtKB=P63213	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Gene=ACTG2|UniProtKB=P63270	Actin, gamma-enteric smooth muscle	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00007	Axon guidance mediated by semaphorins	P00340	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00020	FAS signaling pathway	P00599	Caspase3	TAKRU|Ensembl=ENSTRUG00000015915|UniProtKB=H2UUR6	Uncharacterized protein (Fragment)	IGI	11675509	PubMed	PTHR10454:SF198	CASPASE-3
P00048	PI3 kinase pathway	P01177	P110ACT	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01315	Calcineurin	RAT|RGD=3383|UniProtKB=P20651	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	IGI	7532676	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	DROME|FlyBase=FBgn0261793|UniProtKB=Q07DP5	TATA box binding protein-related factor 2, isoform E	ISS	600075	OMIM	PTHR10126:SF13	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CHICK|Ensembl=ENSGALG00000008898|UniProtKB=F1P2J9	Uncharacterized protein	IC	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04393	Ras Pathway	P04546	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00056	VEGF signaling pathway	P01425	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00018	EGF receptor signaling pathway	P00551	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IGI	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00059	p53 pathway	G04696	Siah	MOUSE|MGI=MGI=108064|UniProtKB=P61092	E3 ubiquitin-protein ligase SIAH1A	ISS	11389839	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00019	Endothelin signaling pathway	P00566	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	20216076	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00005	Angiogenesis	P00192	PAR	MACMU|Gene=NR1I2|UniProtKB=Q8SQ01	Nuclear receptor subfamily 1 group I member 2	ISS			PTHR24082:SF39	NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CAEBR|Gene=CBG02401|UniProtKB=A8WUE7	Protein CBR-NMR-1	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	TAKRU|Ensembl=ENSTRUG00000016241|UniProtKB=H2UX35	Protein kinase C	ISS	11880265	PubMed	PTHR24356:SF305	PROTEIN KINASE C
P00047	PDGF signaling pathway	P01143	ERK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01160	IP3 receptor	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	BOVIN|Ensembl=ENSBTAG00000019210|UniProtKB=F1MJV4	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00048	PI3 kinase pathway	P01188	Gbetagamma	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00009	Axon guidance mediated by netrin	P00357	Netrin	MACMU|Ensembl=ENSMMUG00000000521|UniProtKB=F7A403	Netrin-4	ISS	2538453	PubMed	PTHR10574:SF282	NETRIN-4
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P06213	DPP signaling pathway	P06279	MED	DROME|FlyBase=FBgn0011655|UniProtKB=O62609	Mothers against decapentaplegic homolog	IEA	9395284	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P00053	T cell activation	P01312	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	PANTR|Ensembl=ENSPTRG00000003128|UniProtKB=H2Q2V4	Uncharacterized protein	ISS	12181435	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	PANTR|Gene=CHRM3|UniProtKB=Q9N2A4	Muscarinic acetylcholine receptor M3	TAS	12181435	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01159	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00045	Notch signaling pathway	P01116	Delta	BOVIN|Ensembl=ENSBTAG00000010361|UniProtKB=Q0V7L8	Delta-like protein	ISS	11798067	PubMed	PTHR24044:SF320	DELTA-LIKE PROTEIN 4
P02743	Formyltetrahydroformate biosynthesis	P02953	Cobalamin dependent homocysteine transmethylase	MACMU|Ensembl=ENSMMUG00000010073|UniProtKB=F6T0P5	Uncharacterized protein	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P04393	Ras Pathway	P04559	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	YEAST|SGD=S000001243|UniProtKB=P38886	26S proteasome regulatory subunit RPN10	ISS			PTHR10223:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4
P00049	Parkinson disease	P01235	Fyn kinase	HUMAN|HGNC=4037|UniProtKB=P06241	Tyrosine-protein kinase Fyn	IDA	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00005	Angiogenesis	P00193	SOS-1	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	RAT|RGD=2848|UniProtKB=P08909	5-hydroxytryptamine receptor 2C	ISS	12181435	PubMed	PTHR24247:SF32	5-HYDROXYTRYPTAMINE RECEPTOR 2C
P00036	Interleukin signaling pathway	P00964	p90RSK	BOVIN|Ensembl=ENSBTAG00000002015|UniProtKB=G5E5T2	Uncharacterized protein	ISS	6755374	gi	PTHR24351:SF98	RIBOSOMAL PROTEIN S6 KINASE ALPHA-6
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00021	FGF signaling pathway	P00648	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00036	Interleukin signaling pathway	P00976	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	PANTR|Ensembl=ENSPTRG00000008770|UniProtKB=H2QC99	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF385	MYOSIN-2
P00021	FGF signaling pathway	P00634	MEKK1-5	HUMAN|HGNC=6854|UniProtKB=Q9Y2U5	Mitogen-activated protein kinase kinase kinase 2	IGI	21735556	gi	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	MACMU|Ensembl=ENSMMUG00000019999|UniProtKB=F7FNE2	Uncharacterized protein	ISS	12135927	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DAPPU|EnsemblGenome=DAPPUDRAFT_59367|UniProtKB=E9H7Z0	Guanine nucleotide-binding protein G(O) subunit alpha 1	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00642	MEK1-2	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IGI	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05918	p38 MAPK pathway	P06021	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	20264070	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	PANTR|Ensembl=ENSPTRG00000000843|UniProtKB=H2QZN8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	RAT|RGD=628819|UniProtKB=Q9R283	Short transient receptor potential channel 2	ISS	11055438	PubMed	PTHR10117:SF6	PROTEIN XNTRPC-RELATED
P00024	Glycolysis	P00671	Phosphoglycerate kinase	MONDO|Ensembl=ENSMODG00000004055|UniProtKB=F7C393	Phosphoglycerate kinase	ISS	79199779	PubMed	PTHR11406:SF0	PHOSPHOGLYCERATE KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	XENTR|Xenbase=XB-GENE-480551|UniProtKB=F6XVE6	Uncharacterized protein (Fragment)	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	IC	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05940	GRK5	CHICK|Ensembl=ENSGALG00000009403|UniProtKB=E1BQG4	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF27	G PROTEIN-COUPLED RECEPTOR KINASE 5
P00057	Wnt signaling pathway	P01444	Wnt	MONDO|Ensembl=ENSMODG00000018415|UniProtKB=F6XUZ7	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00023	General transcription regulation	P00662	TFIIA complex	ANOGA|EnsemblGenome=AGAP004370|UniProtKB=Q7QA87	Transcription initiation factor IIA subunit 2	ISS	95241493	PubMed	PTHR10966:SF0	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01163	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	P17325	SPACC	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00046	Oxidative stress response	P01126	ATF2	BOVIN|Ensembl=ENSBTAG00000002295|UniProtKB=F1N177	Uncharacterized protein	ISS	10207617	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	ARATH|TAIR=AT1G04160|UniProtKB=F4I460	Myosin-8	IC			PTHR13140:SF256	MYOSIN-10-RELATED
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	HUMAN|HGNC=11515|UniProtKB=O15178	Brachyury protein	IEP	12356903	PubMed	PTHR11267:SF83	BRACHYURY PROTEIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DICDI|dictyBase=DDB_G0283903|UniProtKB=Q54QB1	Extracellular signal-regulated kinase 2	IDA	95146547	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00009	Axon guidance mediated by netrin	P00366	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00302	ATF	CANLF|Ensembl=ENSCAFG00000006726|UniProtKB=E2RIE0	Uncharacterized protein	ISS	11390664	PubMed	PTHR19304:SF10	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-7
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00052	TGF-beta signaling pathway	P01284	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	XENTR|Xenbase=XB-GENE-1012455|UniProtKB=F6TKH3	Uncharacterized protein (Fragment)	ISS			PTHR11824:SF7	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=98955|UniProtKB=P17553	Proto-oncogene Wnt-3	IDA	11266476	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	DAPPU|EnsemblGenome=DAPPUDRAFT_301818|UniProtKB=E9I1I7	Putative uncharacterized protein	ISS	10684567	PubMed	PTHR24070:SF385	GTPASE HRAS
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00009	Axon guidance mediated by netrin	P00364	cdc42	HUMAN|HGNC=1736|UniProtKB=P60953	Cell division control protein 42 homolog	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00048	PI3 kinase pathway	P01188	Gbetagamma	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02756	N-acetylglucosamine metabolism	P03036	N-acetylglucosamine-6-phosphate deacetylase	HUMAN|HGNC=24262|UniProtKB=Q9Y303	N-acetylglucosamine-6-phosphate deacetylase	ISS			PTHR11113:SF14	N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00012	Cadherin signaling pathway	P00474	Wnt	PANTR|Ensembl=ENSPTRG00000002064|UniProtKB=H2R817	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P00029	Huntington disease	P00780	Microtubule	SCHMA|EnsemblGenome=Smp_192110|UniProtKB=G4VHK8	Putative tubulin beta chain	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	RAT|RGD=2532|UniProtKB=P22388	Endothelin-1	ISS	15117818	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00010	B cell activation	P00381	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DROME|FlyBase=FBgn0000045|UniProtKB=P02574	Actin, larval muscle	IC	10974003	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IDA	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=12775|UniProtKB=O00744	Protein Wnt-10b	IDA	12549854	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	RCA	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00035	Interferon-gamma signaling pathway	P00956	SOCS	HUMAN|HGNC=29846|UniProtKB=O14512	Suppressor of cytokine signaling 7	ISS	12645661	PubMed	PTHR45052:SF1	SUPPRESSOR OF CYTOKINE SIGNALING 7
P00049	Parkinson disease	P01211	ERK	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	IDA	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	BOVIN|Ensembl=ENSBTAG00000013555|UniProtKB=F1MSQ2	Receptor protein serine/threonine kinase	ISS	10683140	PubMed	PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00048	PI3 kinase pathway	P01179	PKB	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CAEBR|Gene=CBG17587|UniProtKB=A8XRA5	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P05730	Endogenous cannabinoid signaling	P05746	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	TAKRU|Ensembl=ENSTRUG00000013411|UniProtKB=H2UB84	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00021	FGF signaling pathway	P00624	14-3-3	YEAST|SGD=S000002506|UniProtKB=P34730	Protein BMH2	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00053	T cell activation	P01312	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IDA	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	SCHPO|PomBase=SPAC6G9.11|UniProtKB=Q92356	Synaptobrevin homolog 1	IC			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00018	EGF receptor signaling pathway	P00565	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IGI	89186920	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00034	Integrin signalling pathway	P00947	Laminin	HUMAN|HGNC=6493|UniProtKB=Q13753	Laminin subunit gamma-2	IPI	2538453	PubMed	PTHR10574:SF313	LAMININ SUBUNIT GAMMA-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IC	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00029	Huntington disease	P00778	NMDA receptor	ANOGA|EnsemblGenome=AGAP001478|UniProtKB=Q7PXM3	AGAP001478-PA	IDA	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00036	Interleukin signaling pathway	P00986	eNOS	RAT|RGD=3186|UniProtKB=Q62600	Nitric oxide synthase, endothelial	ISS	22462730	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00057	Wnt signaling pathway	P01472	Histone deacetylase	YEAST|SGD=S000003162|UniProtKB=P53096	Probable histone deacetylase HOS2	IDA	10485845	PubMed	PTHR10625:SF132	HISTONE DEACETYLASE 3
P00047	PDGF signaling pathway	P01162	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00049	Parkinson disease	P01211	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	18479080	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-030131-9966|UniProtKB=Q6TH03	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00053	T cell activation	P01324	rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	ASHGO|EnsemblGenome=AGOS_ABR222W|UniProtKB=Q75D00	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00056	VEGF signaling pathway	P01408	Akt/PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01332	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01202	p85	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	IDA	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00057	Wnt signaling pathway	P01457	GBeta	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	8925912	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	BOVIN|Ensembl=ENSBTAG00000003054|UniProtKB=F1MC23	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P04393	Ras Pathway	P04558	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	IDA	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	MOUSE|MGI=MGI=1351342|UniProtKB=Q3UVX5	Metabotropic glutamate receptor 5	ISS	12351712	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00036	Interleukin signaling pathway	P00962	ELK	RAT|RGD=1310504|UniProtKB=B4F7D4	ELK4, member of ETS oncogene family (Predicted)	ISS	11846562	PubMed	PTHR11849:SF21	ETS DOMAIN-CONTAINING PROTEIN ELK-4
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	TAKRU|Ensembl=ENSTRUG00000007253|UniProtKB=H2SZQ1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	HUMAN|HGNC=10000|UniProtKB=P49798	Regulator of G-protein signaling 4	ISS	8756726	PubMed	PTHR10845:SF184	REGULATOR OF G-PROTEIN SIGNALING 4
P00021	FGF signaling pathway	P00632	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00046	Oxidative stress response	P01129	JNK1/2	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00034	Integrin signalling pathway	P00931	Integrin beta	CANLF|Ensembl=ENSCAFG00000002519|UniProtKB=F6X717	Integrin beta	ISS	3487386	PubMed	PTHR10082:SF9	INTEGRIN BETA-8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MONDO|Ensembl=ENSMODG00000023429|UniProtKB=F6XI83	Uncharacterized protein	ISS	12181435	PubMed	PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P00010	B cell activation	P00376	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IDA	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P00047	PDGF signaling pathway	P01154	Ras	CANAL|EnsemblGenome=CaO19.1760|UniProtKB=Q59XU5	Ras-like protein 1	ISS	10515923	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	RCA			PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00053	T cell activation	P01306	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00056	VEGF signaling pathway	P01402	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	RCA			PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	TAS	12846562	PubMed	PTHR10202:SF13	PRESENILIN-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DICDI|dictyBase=DDB_G0289811|UniProtKB=Q54GX7	Actin-10	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00048	PI3 kinase pathway	P01199	Galpha	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00007	Axon guidance mediated by semaphorins	P00339	CRMP	MOUSE|MGI=MGI=1349763|UniProtKB=O08553	Dihydropyrimidinase-related protein 2	ISS	Q90635	SPACC	PTHR11647:SF56	DIHYDROPYRIMIDINASE-RELATED PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	DROME|FlyBase=FBgn0040206|UniProtKB=Q9V393	Kurtz arrestin	ISS	4757780	gi	PTHR11792:SF17	KURTZ ARRESTIN
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	DANRE|ZFIN=ZDB-GENE-040426-1347|UniProtKB=F1QJK0	Uncharacterized protein	ISS			PTHR13140:SF458	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	RAT|RGD=620351|UniProtKB=P18265	Glycogen synthase kinase-3 alpha	IDA	21361340	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	21150461	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00029	Huntington disease	P00780	Microtubule	CANLF|Ensembl=ENSCAFG00000018832|UniProtKB=E2QYC2	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	1171954	gi	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	15313841	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	CHICK|Ensembl=ENSGALG00000011809|UniProtKB=F1NMB0	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	CAEBR|Gene=CBG16248|UniProtKB=A8XNT6	Aspartate aminotransferase	ISS			PTHR11879:SF22	ASPARTATE AMINOTRANSFERASE
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	TAS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P02738	De novo purine biosynthesis	P02900	AICAR transformylase	ARATH|TAIR=AT2G35040|UniProtKB=Q8RWT5	AICARFT/IMPCHase bienzyme family protein	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	TAKRU|Ensembl=ENSTRUG00000013411|UniProtKB=H2UB84	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ORYSJ|EnsemblGenome=OS03G0836000|UniProtKB=Q10AZ4	Actin-3	ISS	10974003	PubMed	PTHR11937:SF254	ACTIN-1-RELATED
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IGI	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00010	B cell activation	P00398	IP3R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00021	FGF signaling pathway	P00624	14-3-3	CANLF|Ensembl=ENSCAFG00000003386|UniProtKB=F6Y478	Uncharacterized protein	ISS	5803227	gi	PTHR18860:SF3	14-3-3 PROTEIN THETA
P00046	Oxidative stress response	P01135	p38	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00018	EGF receptor signaling pathway	P00557	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IGI	7565716	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00627	ERK1-2	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00558	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IGI	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	HUMAN|HGNC=4586|UniProtKB=Q13224	Glutamate receptor ionotropic, NMDA 2B	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	IPI	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IDA	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00059	p53 pathway	P04633	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05916	Opioid prodynorphin pathway	P06002	G-protein	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	ANOGA|EnsemblGenome=AGAP001394|UniProtKB=F5HMS4	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05916	Opioid prodynorphin pathway	P06002	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	TAS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00029	Huntington disease	P00794	Hippi	PANTR|Ensembl=ENSPTRG00000015189|UniProtKB=H2QN22	Intraflagellar transport 57 homolog	ISS	11889126	PubMed	PTHR16011:SF0	INTRAFLAGELLAR TRANSPORT PROTEIN 57 HOMOLOG
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	STRCO|Gene=CAC32309|UniProtKB=Q9AK79	tRNA-specific adenosine deaminase	ISS			PTHR11079:SF149	TRNA-SPECIFIC ADENOSINE DEAMINASE
P00034	Integrin signalling pathway	P00951	Jnk	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00059	p53 pathway	P04609	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00035	Interferon-gamma signaling pathway	P00958	PIAS	CANLF|Ensembl=ENSCAFG00000011319|UniProtKB=E2R2U8	Uncharacterized protein	ISS	8682149	PubMed	PTHR10782:SF10	E3 SUMO-PROTEIN LIGASE PIAS3
P04393	Ras Pathway	P04559	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05916	Opioid prodynorphin pathway	P06001	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00021	FGF signaling pathway	P00644	p38	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	IDA	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	RAT|RGD=2344|UniProtKB=P08485	Muscarinic acetylcholine receptor M4	IDA			PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DROME|FlyBase=FBgn0000489|UniProtKB=P16912	Protein kinase DC2	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P02781	Threonine biosynthesis	P03190	Threonine synthase	ASHGO|EnsemblGenome=AGOS_AAR059C|UniProtKB=Q00063	Threonine synthase	ISS	15001715	PubMed	PTHR42690:SF1	THREONINE SYNTHASE-LIKE 2
P00049	Parkinson disease	P01211	ERK	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	IDA	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	ANOGA|EnsemblGenome=AGAP001506|UniProtKB=Q7PXP3	AGAP001506-PA	IC			PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	EMENI|EnsemblGenome=CADANIAG00006296|UniProtKB=Q5ASG1	Putative synaptobrevin homologue SNC1/2 (Eurofung)	ISS			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT2G18170|UniProtKB=Q39027	Mitogen-activated protein kinase 7	IDA	10514528	PubMed	PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P00018	EGF receptor signaling pathway	P00562	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00034	Integrin signalling pathway	P00941	Integrin alpha	MACMU|Ensembl=ENSMMUG00000000153|UniProtKB=F7H4A9	Uncharacterized protein	ISS	3487386	PubMed	PTHR23220:SF89	INTEGRIN ALPHA-3
P04393	Ras Pathway	P04546	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CAEEL|WormBase=WBGene00000858|UniProtKB=P34889	Protein Wnt-2	TAS	8717036	PubMed	PTHR12027:SF77	PROTEIN WNT-5
P00010	B cell activation	P00384	p38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IDA	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00029	Huntington disease	P00807	Actin	CAEBR|Gene=CBG23090|UniProtKB=A8Y4R0	Protein CBG23090	ISS	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=1351340|UniProtKB=Q9QYS2	Metabotropic glutamate receptor 3	IDA	20012997	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P04393	Ras Pathway	P04568	MKK3/6	ORNAN|Ensembl=ENSOANG00000007732|UniProtKB=F6PXH5	Uncharacterized protein (Fragment)	ISS	97059154	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P05912	Dopamine receptor mediated signaling pathway	P05952	EPB41L2	HUMAN|HGNC=3379|UniProtKB=O43491	Band 4.1-like protein 2	IPI	12181426	PubMed	PTHR23280:SF17	BAND 4.1-LIKE PROTEIN 2
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00477	GSK3beta	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	RAT|RGD=3380|UniProtKB=P63331	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	RCA	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	MONDO|Ensembl=ENSMODG00000017109|UniProtKB=F6UJJ9	Uncharacterized protein	ISS	10487978	PubMed	PTHR10749:SF5	PHOSPHORYLASE B KINASE REGULATORY SUBUNIT ALPHA, LIVER ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00206	Wnt	RAT|RGD=1304988|UniProtKB=A0A0G2K6Q8	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00037	Ionotropic glutamate receptor pathway	P01026	KA	ORNAN|Ensembl=ENSOANG00000010302|UniProtKB=F6TDQ6	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	PANTR|Ensembl=ENSPTRG00000000843|UniProtKB=H2QZN8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	SULSO|EnsemblGenome=SSO0230|UniProtKB=Q980Q7	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00047	PDGF signaling pathway	P01146	Ikk	MACMU|Ensembl=ENSMMUG00000018476|UniProtKB=F6X938	Uncharacterized protein	RCA			PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00052	TGF-beta signaling pathway	G01548	I-SMAD	PANTR|Ensembl=ENSPTRG00000010010|UniProtKB=H2QEI2	Mothers against decapentaplegic homolog	ISS	9335505	PubMed	PTHR13703:SF27	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 7
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00128	Erb-B4	ORNAN|Ensembl=ENSOANG00000007021|UniProtKB=F7GAV2	Receptor protein-tyrosine kinase	ISS	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00059	p53 pathway	P01486	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00990	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00047	PDGF signaling pathway	P01162	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	SCLS1|EnsemblGenome=SS1G_03482|UniProtKB=A7EDU2	Guanine nucleotide-binding protein beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	BOVIN|Ensembl=ENSBTAG00000000469|UniProtKB=P67774	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01161	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	ORNAN|Ensembl=ENSOANG00000000493|UniProtKB=F7EPA8	Uncharacterized protein	ISS	1608964	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ARATH|TAIR=AT5G09810|UniProtKB=P53492	Actin-7	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00007	Axon guidance mediated by semaphorins	P00336	Cdk5	BOVIN|Ensembl=ENSBTAG00000007766|UniProtKB=Q02399	Cyclin-dependent-like kinase 5	ISS			PTHR24056:SF46	CYCLIN-DEPENDENT-LIKE KINASE 5
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00737	Rap1GAP	PANTR|Ensembl=ENSPTRG00000000303|UniProtKB=H2QZH2	Uncharacterized protein	ISS	10419452	PubMed	PTHR15711:SF3	RAP1 GTPASE-ACTIVATING PROTEIN 1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00059	p53 pathway	P04623	CBP	HUMAN|HGNC=3373|UniProtKB=Q09472	Histone acetyltransferase p300	IDA	10823891	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01457	GBeta	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00045	Notch signaling pathway	P01113	Pen-2	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	12846562	PubMed	PTHR10202:SF13	PRESENILIN-2
P00047	PDGF signaling pathway	P01142	p90RSK	BOVIN|Gene=RPS6KB1|UniProtKB=Q6TJY3	Ribosomal protein S6 kinase beta-1	ISS	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00887	IRS 1-4	HUMAN|HGNC=6126|UniProtKB=Q9Y4H2	Insulin receptor substrate 2	ISS	5031805	gi	PTHR10614:SF7	INSULIN RECEPTOR SUBSTRATE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01081	Ca2+ channel	RAT|RGD=2247|UniProtKB=P54290	Voltage-dependent calcium channel subunit alpha-2/delta-1	ISS	21601730	PubMed	PTHR10166:SF6	VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-1
P00053	T cell activation	P01320	PLC-gamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00034	Integrin signalling pathway	P00939	Fibronectin	HUMAN|HGNC=3778|UniProtKB=P02751	Fibronectin	IDA	12970173	PubMed	PTHR19143:SF267	FIBRONECTIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	RAT|RGD=2026|UniProtKB=P68035	Actin, alpha cardiac muscle 1	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00015	Circadian clock system	G01497	cry	RAT|RGD=620935|UniProtKB=Q923I8	Cryptochrome-2	IDA	11533252	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00018	EGF receptor signaling pathway	P00550	Grb2	CAEEL|WormBase=WBGene00004774|UniProtKB=P29355	Sex muscle abnormal protein 5	IGI	11457149	PubMed	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CHICK|Ensembl=ENSGALG00000009640|UniProtKB=F1P0I0	Muscarinic acetylcholine receptor	IDA	10069496	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05731	GABA-B receptor II signaling	P05754	Ggamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00056	VEGF signaling pathway	P01403	VEGFR-2	MOUSE|MGI=MGI=96683|UniProtKB=P35918	Vascular endothelial growth factor receptor 2	ISS			PTHR24416:SF45	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2
P00036	Interleukin signaling pathway	P00965	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04393	Ras Pathway	P04546	GSK3	CANLF|Ensembl=ENSCAFG00000004882|UniProtKB=F1PAE3	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00021	FGF signaling pathway	P00632	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	HUMAN|HGNC=11640|UniProtKB=Q9HCS4	Transcription factor 7-like 1	IEP	12356903	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CAEBR|Gene=CBG02401|UniProtKB=A8WUE7	Protein CBR-NMR-1	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00574	Big ET1-4	MOUSE|MGI=MGI=95283|UniProtKB=P22387	Endothelin-1	ISS	15117818	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P05734	Synaptic vesicle trafficking	P05774	NSF	MACMU|Ensembl=ENSMMUG00000005548|UniProtKB=F6YT14	Uncharacterized protein	ISS	601633	OMIM	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00006	Apoptosis signaling pathway	P00310	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	IDA	12660731	PubMed	PTHR10048:SF14	PI-3 KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	XENTR|Xenbase=XB-GENE-1012909|UniProtKB=F6QDK2	Uncharacterized protein	ISS	14724059	PubMed	PTHR11699:SF102	RETINAL DEHYDROGENASE 2
P00019	Endothelin signaling pathway	P00566	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	PANTR|Ensembl=ENSPTRG00000010386|UniProtKB=H2QF61	Tyrosine-protein kinase receptor	ISS	11182407	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IGI	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04393	Ras Pathway	P04574	PLD	HUMAN|HGNC=9068|UniProtKB=O14939	Phospholipase D2	IDA	12615079	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P00005	Angiogenesis	P00254	GTPase	CAEEL|WormBase=WBGene00004357|UniProtKB=Q22038	Ras-like GTP-binding protein rhoA	ISS			PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000001962|UniProtKB=F6V2H6	Uncharacterized protein	ISS	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00059	p53 pathway	G04694	p110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00944	Actin	MONBE|Gene=37852|UniProtKB=A9V489	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00025	Hedgehog signaling pathway	P00682	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00050	Plasminogen activating cascade	P01246	Plasmin	MACMU|Gene=PLG|UniProtKB=P12545	Plasminogen	ISS	4505881	gi	PTHR24261:SF6	PLASMINOGEN
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00029	Huntington disease	P00807	Actin	CAEBR|Gene=CBG02167|UniProtKB=A8WS37	Protein CBG02167	ISS	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	ARATH|TAIR=AT1G55970|UniProtKB=Q9LG11	Histone acetyltransferase HAC4	TAS	10664585	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00005	Angiogenesis	P00238	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	G04694	p110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	G01540	BDNF	ORNAN|Ensembl=ENSOANG00000013030|UniProtKB=O02795	Brain-derived neurotrophic factor (Fragment)	ISS	11724916	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	CANLF|Ensembl=ENSCAFG00000015662|UniProtKB=E2RHY4	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_79607|UniProtKB=C3ZHN4	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	CANLF|Ensembl=ENSCAFG00000004882|UniProtKB=F1PAE3	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	MYCTU|EnsemblGenome=Rv1981c|UniProtKB=P9WH73	Ribonucleoside-diphosphate reductase subunit beta nrdF1	ISS			PTHR23409:SF32	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00036	Interleukin signaling pathway	P00985	PDK1/2	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00049	Parkinson disease	P01212	p38 MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00034	Integrin signalling pathway	P00927	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00018	EGF receptor signaling pathway	P00545	JNK1-3	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00024	Glycolysis	P00671	Phosphoglycerate kinase	RAT|RGD=619878|UniProtKB=P16617	Phosphoglycerate kinase 1	ISS	79199779	PubMed	PTHR11406:SF14	PHOSPHOGLYCERATE KINASE 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00203	Erk	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IDA	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	MACMU|Ensembl=ENSMMUG00000002658|UniProtKB=F7CB14	Uncharacterized protein	ISS	12181435	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00634	MEKK1-5	MOUSE|MGI=MGI=1346874|UniProtKB=Q61084	Mitogen-activated protein kinase kinase kinase 3	ISS	8649450	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00010	B cell activation	P00397	IKK	MACMU|Ensembl=ENSMMUG00000018476|UniProtKB=F6X938	Uncharacterized protein	ISS	9346484	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000008826|UniProtKB=F6XUU0	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00188	Ets	RAT|RGD=2583|UniProtKB=P41156	Protein C-ets-1	ISS	9157999	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00054	Toll receptor signaling pathway	P01369	MKK1	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	RAT|RGD=71014|UniProtKB=Q04400	Adenylate cyclase type 5	IC	93156838	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=98962|UniProtKB=P28047	Protein Wnt-7b	TAS	8717036	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00046	Oxidative stress response	P01131	MKP5	ANOGA|EnsemblGenome=AGAP012237|UniProtKB=Q7PV94	Dual specificity protein phosphatase	TAS			PTHR10159:SF489	DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3
P05916	Opioid prodynorphin pathway	P06002	G-protein	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00034	Integrin signalling pathway	P00948	Rho	SCLS1|EnsemblGenome=SS1G_03867|UniProtKB=A7EEX6	RhoA protein	ISS	11973360	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P04393	Ras Pathway	P04579	Shc	MOUSE|MGI=MGI=98296|UniProtKB=P98083	SHC-transforming protein 1	IDA	7798194	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	TAS	94179345	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000000289|UniProtKB=F7A9T0	Uncharacterized protein	ISS	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00009	Axon guidance mediated by netrin	P00366	Rac	CHICK|Ensembl=ENSGALG00000002859|UniProtKB=F6UBD2	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00019	Endothelin signaling pathway	P00590	IP3 R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00004	Alzheimer disease-presenilin pathway	P00168	E-cadherin intracellular fragment	PANTR|Ensembl=ENSPTRG00000008269|UniProtKB=H2QBE4	Cadherin 3, type 1, P-cadherin (Placental)	ISS	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	THEKO|EnsemblGenome=TK1431|UniProtKB=O59650	Glutamate dehydrogenase	ISS			PTHR11606:SF13	GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000021941|UniProtKB=F6UY89	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF97	PROTOCADHERIN BETA-15
P00057	Wnt signaling pathway	P01451	Galpha	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	IDA	1650351	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00005	Angiogenesis	P00190	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	2574500	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Ensembl=ENSCAFG00000010298|UniProtKB=P11616	Adenosine receptor A1	ISS	12515326	PubMed	PTHR24246:SF1	ADENOSINE RECEPTOR A1
P00009	Axon guidance mediated by netrin	P00363	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00965	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00038	JAK/STAT signaling pathway	P01031	PIAS	CANLF|Ensembl=ENSCAFG00000017599|UniProtKB=E2RJ88	Uncharacterized protein	ISS	8682149	PubMed	PTHR10782:SF12	E3 SUMO-PROTEIN LIGASE PIAS2
P00014	Cholesterol biosynthesis	P00494	Squalene monooxygenas	SCHPO|PomBase=SPBC713.12|UniProtKB=Q9C1W3	Probable squalene monooxygenase	ISS			PTHR10835:SF0	SQUALENE MONOOXYGENASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CHICK|Ensembl=ENSGALG00000011248|UniProtKB=F1P354	Phosphoinositide phospholipase C	ISS			PTHR10336:SF84	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Ensembl=ENSPTRG00000022245|UniProtKB=H2QZ29	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00057	Wnt signaling pathway	P01471	alpha-catenin	MOUSE|MGI=MGI=88274|UniProtKB=P26231	Catenin alpha-1	IDA	1904011	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	IDA	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	SCLS1|EnsemblGenome=SS1G_03482|UniProtKB=A7EDU2	Guanine nucleotide-binding protein beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00053	T cell activation	P01306	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P02738	De novo purine biosynthesis	P02907	dADP kinase	ARATH|TAIR=AT4G09320|UniProtKB=P39207	Nucleoside diphosphate kinase 1	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00053	T cell activation	P01332	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00629	PP2A	CANLF|Ensembl=ENSCAFG00000001753|UniProtKB=F1P714	Uncharacterized protein	ISS	12110603	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00021	FGF signaling pathway	P00645	Rac	DICDI|dictyBase=DDB_G0286555|UniProtKB=P34147	Rho-related protein racA	ISS	94124042	PubMed	PTHR24072:SF183	RHO-RELATED PROTEIN RACA
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CANLF|Ensembl=ENSCAFG00000008760|UniProtKB=E2RTG8	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04393	Ras Pathway	P04553	PAK	CHICK|Ensembl=ENSGALG00000000681|UniProtKB=E1C3P6	Uncharacterized protein	ISS	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00012	Cadherin signaling pathway	P00475	Frizzled	ORNAN|Ensembl=ENSOANG00000004982|UniProtKB=F7DIA9	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF34	FRIZZLED-2
P00047	PDGF signaling pathway	P01161	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00366	Rac	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS	15470041	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06702	p65	HUMAN|HGNC=9955|UniProtKB=Q04206	Transcription factor p65	RCA	10049353	PubMed	PTHR24169:SF1	TRANSCRIPTION FACTOR P65
P00049	Parkinson disease	P01229	Pael-R	PANTR|Ensembl=ENSPTRG00000001845|UniProtKB=H2Q0W6	Uncharacterized protein	ISS			PTHR24243:SF33	PROSAPOSIN RECEPTOR GPR37L1
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=1751|UniProtKB=P55289	Cadherin-12	IDA	8120095	PubMed	PTHR24027:SF96	CADHERIN-12
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-050417-59|UniProtKB=Q15KE4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00046	Oxidative stress response	P01123	Bcl-2	CHICK|Ensembl=ENSGALG00000012885|UniProtKB=Q00709	Apoptosis regulator Bcl-2	TAS	1508712	PubMed	PTHR11256:SF11	APOPTOSIS REGULATOR BCL-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000015717|UniProtKB=F6SFA9	Serotonin receptor type 1B	ISS	12181435	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P00021	FGF signaling pathway	P00632	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IGI	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04384	Gamma-aminobutyric acid synthesis	P04482	Glutamate decarboxylase	DANRE|ZFIN=ZDB-GENE-030909-9|UniProtKB=F1R9E8	Uncharacterized protein	ISS	2247446	PubMed	PTHR11999:SF77	GLUTAMATE DECARBOXYLASE 2
P04398	p53 pathway feedback loops 2	G04714	PTEN	XENTR|Xenbase=XB-GENE-491433|UniProtKB=B1H2U0	Pten protein	ISS	10555148	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MONDO|Ensembl=ENSMODG00000005136|UniProtKB=F7EQH3	Uncharacterized protein (Fragment)	ISS	9230079	PubMed	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00053	T cell activation	P01306	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	91232861	PubMed	PTHR24070:SF385	GTPASE HRAS
P00059	p53 pathway	G04692	R2	HUMAN|HGNC=10452|UniProtKB=P31350	Ribonucleoside-diphosphate reductase subunit M2	ISS			PTHR23409:SF20	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01439	C-terminal Binding Protein	CHICK|Ensembl=ENSGALG00000009738|UniProtKB=E1C7L0	Uncharacterized protein	ISS	10375506	PubMed	PTHR10996:SF72	C-TERMINAL-BINDING PROTEIN 2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00034	Integrin signalling pathway	P00936	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MONDO|Ensembl=ENSMODG00000008463|UniProtKB=F7GET1	Uncharacterized protein	ISS	21240406	PubMed	PTHR10845:SF196	REGULATOR OF G-PROTEIN SIGNALING 17
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	DROME|FlyBase=FBgn0001991|UniProtKB=Q24270	Voltage-dependent calcium channel type D subunit alpha-1	IC	11956331	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00036	Interleukin signaling pathway	P00996	STAT	HUMAN|HGNC=11366|UniProtKB=P42229	Signal transducer and activator of transcription 5A	IDA	8732682	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00018	EGF receptor signaling pathway	P00539	14-3-3	RAT|RGD=61998|UniProtKB=P35213	14-3-3 protein beta/alpha	ISS	10407019	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P02786	Vitamin B6 biosynthesis	P03225	1-Deoxyxylulose-5-phosphate synthase	ECOLI|EcoGene=EG13612|UniProtKB=P77488	1-deoxy-D-xylulose-5-phosphate synthase	ISS			PTHR43322:SF6	1-DEOXY-D-XYLULOSE-5-PHOSPHATE SYNTHASE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	XENTR|Xenbase=XB-GENE-491459|UniProtKB=L7N3Q3	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P02748	Isoleucine biosynthesis	P02998	Dihydroxyacid dehydratase	ARATH|TAIR=AT3G23940|UniProtKB=Q9LIR4	Dihydroxy-acid dehydratase, chloroplastic	ISS			PTHR21000:SF17	DIHYDROXY-ACID DEHYDRATASE, CHLOROPLASTIC
P02748	Isoleucine biosynthesis	P02995	Threonine dehydratase	FUSNN|EnsemblGenome=FN1411|UniProtKB=Q8RDT9	Threonine dehydratase	ISS			PTHR43419:SF8	THREONINE AMMONIA-LYASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DANRE|ZFIN=ZDB-GENE-030131-6503|UniProtKB=Q7ZUC5	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF297	PROTEIN KINASE C DELTA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	YEAST|SGD=S000005854|UniProtKB=P33328	Synaptobrevin homolog 2	IC			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	IPI	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MOUSE|MGI=MGI=894644|UniProtKB=Q8CC27	Voltage-dependent L-type calcium channel subunit beta-2	ISS	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	DROME|FlyBase=FBgn0039218|UniProtKB=Q9VC49	DNA-directed RNA polymerases I, II, and III subunit RPABC5	ISS			PTHR23431:SF3	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00029	Huntington disease	P00805	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00053	T cell activation	P01307	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00321	HSP70	MACMU|Ensembl=ENSMMUG00000006799|UniProtKB=F7H1B9	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF239	HEAT SHOCK COGNATE 71 KDA PROTEIN
P00010	B cell activation	P00374	Lyn	ORNAN|Ensembl=ENSOANG00000005501|UniProtKB=F6X6I5	Tyrosine-protein kinase	ISS	1371009	PubMed	PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P02763	Peptidoglycan biosynthesis	P03091	D-alanine-D-alanine ligase	DEIRA|EnsemblGenome=DR_0362|UniProtKB=Q9RXF1	D-alanine--D-alanine ligase	ISS			PTHR23132:SF8	D-ALANINE--D-ALANINE LIGASE A
P00018	EGF receptor signaling pathway	P00539	14-3-3	XENTR|Xenbase=XB-GENE-996375|UniProtKB=F7DY42	Uncharacterized protein	ISS	9450960	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000014751|UniProtKB=H2R8D8	Phosphoinositide phospholipase C	ISS			PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P04393	Ras Pathway	P04558	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01455	Smad4	MOUSE|MGI=MGI=894293|UniProtKB=P97471	Mothers against decapentaplegic homolog 4	IDA	9395284	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P04393	Ras Pathway	P04564	MAPKAP	HUMAN|HGNC=6887|UniProtKB=P49137	MAP kinase-activated protein kinase 2	IDA	7923354	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00005	Angiogenesis	P00211	GSK3beta	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00059	p53 pathway	P01480	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	RAT|RGD=620577|UniProtKB=Q62636	Ras-related protein Rap-1b	IDA	10476970	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00021	FGF signaling pathway	P00632	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	IGI	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	MACMU|Ensembl=ENSMMUG00000010509|UniProtKB=F7B8E8	Clathrin heavy chain	ISS	9388255	PubMed	PTHR10292:SF7	CLATHRIN HEAVY CHAIN 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CAEEL|WormBase=WBGene00004039|UniProtKB=Q21754	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF147	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-2
P00006	Apoptosis signaling pathway	P00308	Mcl1	DANRE|ZFIN=ZDB-GENE-000511-7|UniProtKB=Q1L8X3	Uncharacterized protein	ISS			PTHR11256:SF46	INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN MCL-1
P00053	T cell activation	P01332	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00049	Parkinson disease	P01242	Casein kinase I	MONDO|Ensembl=ENSMODG00000025188|UniProtKB=F7C1G3	Uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00029	Huntington disease	P00796	Kainate receptor	MOUSE|MGI=MGI=95817|UniProtKB=Q8BMF5	Glutamate receptor ionotropic, kainate 4	ISS	12778120	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DROME|FlyBase=FBgn0259680|UniProtKB=P83099	Putative protein kinase C delta type homolog	ISS	15572354	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	BOVIN|Ensembl=ENSBTAG00000037429|UniProtKB=F1MGM3	Uncharacterized protein	ISS	11454663	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P00053	T cell activation	P01319	PAK	ORNAN|Ensembl=ENSOANG00000002406|UniProtKB=F7BAS2	Uncharacterized protein	ISS	7559398	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	PANTR|Ensembl=ENSPTRG00000001112|UniProtKB=H2PZP2	Ras homolog gene family, member C	ISS	14871999	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00054	Toll receptor signaling pathway	P01376	Uev1A	BOVIN|Ensembl=ENSBTAG00000027316|UniProtKB=Q3SZ52	Ubiquitin-conjugating enzyme E2 variant 1	ISS			PTHR43915:SF2	UBIQUITIN-CONJUGATING ENZYME E2 VARIANT 1
P00053	T cell activation	P01305	Calmodulin	MONBE|Gene=11217|UniProtKB=A9V8J8	Predicted protein	ISS			PTHR23050:SF245	AT16150P-RELATED
P04393	Ras Pathway	P04557	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00049	Parkinson disease	P01211	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	IDA	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00049	Parkinson disease	P01214	CHIP	MOUSE|MGI=MGI=1891731|UniProtKB=Q9WUD1	STIP1 homology and U box-containing protein 1	ISS	12150907	PubMed	PTHR44284:SF1	E3 UBIQUITIN-PROTEIN LIGASE CHIP
P00057	Wnt signaling pathway	P01451	Galpha	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01150	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	CANLF|Ensembl=ENSCAFG00000015662|UniProtKB=E2RHY4	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00057	Wnt signaling pathway	P01448	CBP	CAEEL|WormBase=WBGene00000366|UniProtKB=P34545	Protein cbp-1	ISS	10769018	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00023	General transcription regulation	P00662	TFIIA complex	MONDO|Ensembl=ENSMODG00000003731|UniProtKB=F7EVS0	Uncharacterized protein	ISS	600519	OMIM	PTHR12694:SF7	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01465	Ggamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=15983|UniProtKB=P56704	Protein Wnt-3a	IDA	11266476	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	RCA	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01446	Calcineurin	ARATH|TAIR=AT5G55990|UniProtKB=Q8LAS7	Calcineurin B-like protein 2	IDA	12015605	PubMed	PTHR23056:SF51	CALCINEURIN B-LIKE PROTEIN 2-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MOUSE|MGI=MGI=102705|UniProtKB=P63213	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00046	Oxidative stress response	P01135	p38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_127488|UniProtKB=C3XYC7	Putative uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00035	Interferon-gamma signaling pathway	P00953	Jak1	HUMAN|HGNC=6190|UniProtKB=P23458	Tyrosine-protein kinase JAK1	TAS	9637709	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00010	B cell activation	P00376	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P04397	p53 pathway by glucose deprivation	P04641	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00205	GAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	2842690	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	PANTR|Ensembl=ENSPTRG00000012501|UniProtKB=P61072	C-X-C chemokine receptor type 4	ISS	4503175	gi	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P00037	Ionotropic glutamate receptor pathway	P01020	NSF	MONDO|Ensembl=ENSMODG00000011031|UniProtKB=F7F4B9	Uncharacterized protein	ISS	7969419	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00009	Axon guidance mediated by netrin	P00366	Rac	MACMU|Ensembl=ENSMMUG00000021075|UniProtKB=F7GY91	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00011	Blood coagulation	P00416	Prothrombin	BOVIN|Ensembl=ENSBTAG00000007148|UniProtKB=P00735	Prothrombin	ISS	+176930	OMIM	PTHR24254:SF10	PROTHROMBIN
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00034	Integrin signalling pathway	P00924	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CHICK|Ensembl=ENSGALG00000008591|UniProtKB=E1BZF6	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00020	FAS signaling pathway	P00615	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P06215	MYO signaling pathway	P06317	PPM1A	DROME|FlyBase=FBgn0086361|UniProtKB=Q961C5	Alphabet, isoform E	IEA	http://flybase.org/reports/FBgn0086361.html	Website	PTHR13832:SF524	PROTEIN PHOSPHATASE 1A, MAGNESIUM DEPENDENT, ALPHA ISOFORM-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Ensembl=ENSBTAG00000037726|UniProtKB=P10895	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	15611108	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01173	STAT	HUMAN|HGNC=11364|UniProtKB=P40763	Signal transducer and activator of transcription 3	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P02736	Coenzyme A biosynthesis	P02884	Dephospho-CoA kinase	BACSU|EnsemblGenome=BSU29060|UniProtKB=O34932	Dephospho-CoA kinase	ISS			PTHR10695:SF26	BIFUNCTIONAL COENZYME A SYNTHASE
P05731	GABA-B receptor II signaling	P05754	Ggamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00019	Endothelin signaling pathway	P00567	PKG	CANLF|Ensembl=ENSCAFG00000008898|UniProtKB=F6Y448	cGMP-dependent protein kinase	ISS	12775716	PubMed	PTHR24353:SF24	SUBFAMILY NOT NAMED
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	SCLS1|EnsemblGenome=SS1G_01827|UniProtKB=A7E947	Uncharacterized protein	ISS			PTHR23073:SF13	26S PROTEASE REGULATORY SUBUNIT 7
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01160	IP3 receptor	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P05915	Opioid proenkephalin pathway	P05991	Enkephalin	MOUSE|MGI=MGI=104629|UniProtKB=P22005	Proenkephalin-A	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	CAEEL|WormBase=WBGene00001746|UniProtKB=Q9U2Q9	Glycogen synthase kinase-3	ISS	11995474	gi	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IGI	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00047	PDGF signaling pathway	P01173	STAT	HUMAN|HGNC=11364|UniProtKB=P40763	Signal transducer and activator of transcription 3	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04393	Ras Pathway	P04541	p90RSK	BOVIN|Ensembl=ENSBTAG00000014447|UniProtKB=A4IFF4	Ribosomal protein S6 kinase	ISS	15226426	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P05916	Opioid prodynorphin pathway	P06002	G-protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	PANTR|Ensembl=ENSPTRG00000033974|UniProtKB=H2RBS1	Interleukin 11 receptor, alpha	ISS	12569176	PubMed	PTHR23036:SF29	INTERLEUKIN-11 RECEPTOR SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00859	NFkappaB	MOUSE|MGI=MGI=1194908|UniProtKB=O54910	NF-kappa-B inhibitor epsilon	IDA			PTHR24118:SF37	NF-KAPPA-B INHIBITOR EPSILON
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00012	Cadherin signaling pathway	P00471	Cadherin	BOVIN|Ensembl=ENSBTAG00000004081|UniProtKB=F1MC84	Uncharacterized protein	ISS	8120095	PubMed	PTHR24026:SF49	PROTOCADHERIN FAT 3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000000985|UniProtKB=F6VRS9	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00047	PDGF signaling pathway	P01150	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IDA	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00021	FGF signaling pathway	P00632	Akt	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	IGI	12655147	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00005	Angiogenesis	P00223	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IPI	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	ARATH|TAIR=AT3G03910|UniProtKB=Q9S7A0	Probable glutamate dehydrogenase 3	ISS			PTHR11606:SF18	GLUTAMATE DEHYDROGENASE 1-RELATED
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	HUMAN|HGNC=6857|UniProtKB=Q99683	Mitogen-activated protein kinase kinase kinase 5	IGI	8974401	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00053	T cell activation	P01300	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00788	Calpain	RAT|RGD=2268|UniProtKB=Q07009	Calpain-2 catalytic subunit	IDA	11675509	PubMed	PTHR10183:SF268	CALPAIN-2 CATALYTIC SUBUNIT
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CAEBR|Gene=CBG04190|UniProtKB=A8WWD7	Protein CBR-MEK-2	ISS	17508425	gi	PTHR24361:SF629	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00778	NMDA receptor	MOUSE|MGI=MGI=95822|UniProtKB=Q01098	Glutamate receptor ionotropic, NMDA 2C	IDA	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000015241|UniProtKB=Q5IS72	D(3) dopamine receptor	ISS	7651368	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	MOUSE|MGI=MGI=94926|UniProtKB=P51436	D(4) dopamine receptor	ISS	2137198	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P04393	Ras Pathway	P04546	GSK3	MOUSE|MGI=MGI=2152453|UniProtKB=Q2NL51	Glycogen synthase kinase-3 alpha	ISS	183955	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00005	Angiogenesis	P00243	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MONDO|Ensembl=ENSMODG00000015246|UniProtKB=F6UJF5	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	ARATH|TAIR=AT5G28030|UniProtKB=F4K5T2	Bifunctional cystathionine gamma-lyase/cysteine synthase	ISS			PTHR10314:SF97	BIFUNCTIONAL L-3-CYANOALANINE SYNTHASE/CYSTEINE SYNTHASE D1-RELATED
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	TAS			PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	ISS	6466184	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05913	Enkephalin release	P05974	G-Protein (i)	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	IC	15860573	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IGI	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=62064|UniProtKB=P23944	Alpha-1D adrenergic receptor	IDA			PTHR24248:SF14	ALPHA-1D ADRENERGIC RECEPTOR
P00049	Parkinson disease	P01235	Fyn kinase	CANLF|Ensembl=ENSCAFG00000003995|UniProtKB=E2RC09	Tyrosine-protein kinase	ISS	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00021	FGF signaling pathway	P00645	Rac	ORYSJ|EnsemblGenome=OS02G0120800|UniProtKB=Q6ZHA3	Rac-like GTP-binding protein 6	ISS	11950993	PubMed	PTHR24072:SF261	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	PANTR|Ensembl=ENSPTRG00000004215|UniProtKB=H2Q4M7	Uncharacterized protein	ISS	12356903	PubMed	PTHR10201:SF143	MATRILYSIN
P00007	Axon guidance mediated by semaphorins	P00331	PAK	BOVIN|Ensembl=ENSBTAG00000010191|UniProtKB=Q08E52	Serine/threonine-protein kinase PAK 1	ISS	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00053	T cell activation	P01322	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05916	Opioid prodynorphin pathway	P06001	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00047	PDGF signaling pathway	P01172	c-Myc	PANTR|Ensembl=ENSPTRG00000000565|UniProtKB=H2PYQ5	C-myc binding protein	ISS	15094771	PubMed	PTHR13168:SF0	C-MYC-BINDING PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00114	actin	RAT|RGD=1309504|UniProtKB=D3ZRN3	Protein Actbl2	ISS	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00012	Cadherin signaling pathway	P00470	F-actin	TAKRU|Ensembl=ENSTRUG00000005447|UniProtKB=P68142	Actin, cytoplasmic 1	IC	3487386	PubMed	PTHR11937:SF354	SUBFAMILY NOT NAMED
P00046	Oxidative stress response	P01129	JNK1/2	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	TAS	12040174	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	HUMAN|HGNC=9871|UniProtKB=P20936	Ras GTPase-activating protein 1	TAS	11847220	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	XENTR|Xenbase=XB-GENE-480551|UniProtKB=F6XVE6	Uncharacterized protein (Fragment)	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P02747	Histidine biosynthesis	P02988	Histidinal dehydrogenase	DEIRA|EnsemblGenome=DR_2140|UniProtKB=Q9RSI4	Histidinol dehydrogenase	ISS			PTHR21256:SF2	HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000008806|UniProtKB=H2QCB5	Adenosine receptor A2	ISS			PTHR24246:SF18	ADENOSINE RECEPTOR A2B
P00047	PDGF signaling pathway	P01148	Grb2	CAEEL|WormBase=WBGene00004774|UniProtKB=P29355	Sex muscle abnormal protein 5	ISS	17569445	gi	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P02783	Tryptophan biosynthesis	P03207	Tryptophan synthase A	BACSU|EnsemblGenome=BSU22630|UniProtKB=P07601	Tryptophan synthase alpha chain	ISS			PTHR43455:SF1	SUBFAMILY NOT NAMED
P00059	p53 pathway	P01486	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01163	c-Jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00632	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00020	FAS signaling pathway	P00615	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	PANTR|Ensembl=ENSPTRG00000000843|UniProtKB=H2QZN8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00037	Ionotropic glutamate receptor pathway	P01018	Glu1	DROME|FlyBase=FBgn0264000|UniProtKB=M9PHV5	Glutamate receptor IB, isoform B	ISS	12446127	PubMed	PTHR18966:SF270	GLUTAMATE RECEPTOR 1-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MOUSE|MGI=MGI=2152453|UniProtKB=Q2NL51	Glycogen synthase kinase-3 alpha	ISS	2164470	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00021	FGF signaling pathway	P00627	ERK1-2	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05918	p38 MAPK pathway	P06043	ASK1	BOVIN|Ensembl=ENSBTAG00000009065|UniProtKB=F1MXH6	Uncharacterized protein	ISS	11730323	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00899	IRS 1-4	HUMAN|HGNC=6125|UniProtKB=P35568	Insulin receptor substrate 1	TAS	15110093	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CANLF|Ensembl=ENSCAFG00000000443|UniProtKB=E2QSF4	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IDA	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00025	Hedgehog signaling pathway	P00685	Smoothened	BOVIN|Ensembl=ENSBTAG00000013287|UniProtKB=E1BE57	Uncharacterized protein	ISS	942251	PubMed	PTHR11309:SF35	SMOOTHENED HOMOLOG
P00029	Huntington disease	P00807	Actin	MOUSE|MGI=MGI=87909|UniProtKB=P62737	Actin, aortic smooth muscle	IDA	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00053	T cell activation	P01333	cdc42	HUMAN|HGNC=1736|UniProtKB=P60953	Cell division control protein 42 homolog	IDA	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00047	PDGF signaling pathway	P01143	ERK	DICDI|dictyBase=DDB_G0283903|UniProtKB=Q54QB1	Extracellular signal-regulated kinase 2	ISS	10851062	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	ORNAN|Ensembl=ENSOANG00000006877|UniProtKB=F7CQF2	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	IC	15737619	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00054	Toll receptor signaling pathway	P01360	IKKbeta	BOVIN|Ensembl=ENSBTAG00000007599|UniProtKB=Q95KV0	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01170	PDGF	XENTR|Xenbase=XB-GENE-484495|UniProtKB=F6WRD7	Uncharacterized protein	ISS			PTHR11633:SF3	PLATELET-DERIVED GROWTH FACTOR SUBUNIT A
P02738	De novo purine biosynthesis	P02909	GDP reductase	DROME|FlyBase=FBgn0011703|UniProtKB=P48591	Ribonucleoside-diphosphate reductase large subunit	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P02734	Chorismate biosynthesis	P02872	3-Dehydroquinate synthase	GLOVI|EnsemblGenome=BAC90454|UniProtKB=Q7NHM2	3-dehydroquinate synthase	ISS			PTHR43622:SF1	3-DEHYDROQUINATE SYNTHASE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CANLF|Ensembl=ENSCAFG00000005662|UniProtKB=E2R907	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	ISS	8170357	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g195622|UniProtKB=A7T2Q5	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IDA	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04570	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04567	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IDA	7937853	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	TAS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P02766	Phenylethylamine degradation	P03103	Phenylethylamine oxidase	ARATH|TAIR=AT1G31670|UniProtKB=Q9C6V7	Amine oxidase	ISS			PTHR10638:SF36	AMINE OXIDASE
P05731	GABA-B receptor II signaling	P05752	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00648	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00005	Angiogenesis	P00230	PDGFR	HUMAN|HGNC=8803|UniProtKB=P16234	Platelet-derived growth factor receptor alpha	IDA	12374780	PubMed	PTHR24416:SF52	PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA
P00047	PDGF signaling pathway	P01161	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MACMU|Ensembl=ENSMMUG00000009341|UniProtKB=F6UA54	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00034	Integrin signalling pathway	P00920	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=4503|UniProtKB=Q9Y5Y3	Probable G-protein coupled receptor 45	IDA			PTHR24245:SF4	G-PROTEIN COUPLED RECEPTOR 45-RELATED
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	MOUSE|MGI=MGI=2151136|UniProtKB=Q9JI18	Low-density lipoprotein receptor-related protein 1B	IDA	11907044	PubMed	PTHR44025:SF7	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B
P04393	Ras Pathway	P04578	Rho	XENTR|Xenbase=XB-GENE-941426|UniProtKB=Q28HZ4	Novel Rho protein	ISS	12039949	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	2837282	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	TAKRU|Ensembl=ENSTRUG00000016241|UniProtKB=H2UX35	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF305	PROTEIN KINASE C
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	XENTR|Xenbase=XB-GENE-969601|UniProtKB=Q28H40	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_127490|UniProtKB=C3XYC5	Putative uncharacterized protein	IDA	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	MACMU|Ensembl=ENSMMUG00000010122|UniProtKB=F7HF84	Casein kinase I isoform epsilon	ISS	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P02788	Xanthine and guanine salvage pathway	P03248	Deoxyguanosine phosphorylase	STRCO|Gene=CAD30908|UniProtKB=Q9EWV2	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	BOVIN|Ensembl=ENSBTAG00000040056|UniProtKB=F1MRY8	Uncharacterized protein	ISS	10048442	gi	PTHR24230:SF8	LEUKOTRIENE B4 RECEPTOR 2
P02729	Ascorbate degradation	P02849	L-xylulose kinase	ECOLI|EcoGene=EG13804|UniProtKB=P77432	Autoinducer-2 kinase	ISS			PTHR43095:SF1	AUTOINDUCER-2 KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	IC	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01428	Frizzled	CHICK|Gene=FZD10|UniProtKB=Q9PWH2	Frizzled-10	IDA	11212302	PubMed	PTHR11309:SF86	FRIZZLED-10
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	BATDJ|Gene=BATDEDRAFT_32931|UniProtKB=F4NX01	Putative uncharacterized protein	ISS			PTHR12458:SF8	CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	MACMU|Ensembl=ENSMMUG00000023046|UniProtKB=F6V829	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00053	T cell activation	P01305	Calmodulin	DAPPU|EnsemblGenome=DAPPUDRAFT_442795|UniProtKB=E9H5Z2	Calmodulin	ISS			PTHR23050:SF245	AT16150P-RELATED
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8657|UniProtKB=Q9NPG4	Protocadherin-12	IDA	8120095	PubMed	PTHR24028:SF42	PROTOCADHERIN-12
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00006	Apoptosis signaling pathway	P00310	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00021	FGF signaling pathway	P00645	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MONDO|Ensembl=ENSMODG00000014736|UniProtKB=F6ZC55	Phosphoinositide phospholipase C	ISS			PTHR10336:SF84	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2
P00047	PDGF signaling pathway	P01153	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00010	B cell activation	P00368	vav	MONDO|Ensembl=ENSMODG00000002796|UniProtKB=F7EJL2	Uncharacterized protein	ISS	14623913	PubMed	PTHR22826:SF97	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Ensembl=ENSBTAG00000037726|UniProtKB=P10895	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	7822322	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CAEEL|WormBase=WBGene00000067|UniProtKB=O45815	ACTin	IDA	11889126	PubMed	PTHR11937:SF352	ACTIN
P00060	Ubiquitin proteasome pathway	P01491	E2	ARATH|TAIR=AT3G52560|UniProtKB=Q9SVD7	Ubiquitin-conjugating enzyme E2 variant 1D	ISS			PTHR43915:SF4	UBIQUITIN-CONJUGATING ENZYME E2 VARIANT 1D
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00059	p53 pathway	P04609	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	1171954	gi	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00054	Toll receptor signaling pathway	P01375	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MONDO|Ensembl=ENSMODG00000012546|UniProtKB=F6PM16	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00036	Interleukin signaling pathway	P00976	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P06959	CCKR signaling map	P07090	MAPK8-10	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	RCA	12193476	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00240	FRS-2	HUMAN|HGNC=16971|UniProtKB=Q8WU20	Fibroblast growth factor receptor substrate 2	IDA	12571252	PubMed	PTHR21258:SF40	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000000985|UniProtKB=F6VRS9	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	PANTR|Ensembl=ENSPTRG00000017042|UniProtKB=H2QR61	Dihydrofolate reductase	ISS			PTHR22778:SF39	DIHYDROFOLATE REDUCTASE
P00036	Interleukin signaling pathway	P00990	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00054	Toll receptor signaling pathway	P01355	AP1	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00892	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8051109	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01067	AChE	PANTR|Ensembl=ENSPTRG00000019514|UniProtKB=H2R3Y8	Carboxylic ester hydrolase	ISS	87080761	PubMed	PTHR11559:SF356	ACETYLCHOLINESTERASE
P00019	Endothelin signaling pathway	P00566	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000021963|UniProtKB=F6S1W0	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF234	PROTOCADHERIN GAMMA-C5
P00010	B cell activation	P00368	vav	CANLF|Ensembl=ENSCAFG00000018590|UniProtKB=E2RGT8	Uncharacterized protein	ISS	14623913	PubMed	PTHR22826:SF112	PROTO-ONCOGENE VAV
P00019	Endothelin signaling pathway	P00590	IP3 R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02784	Tyrosine biosynthesis	P03213	Aromatic amino acid aminotransferase	PANTR|Ensembl=ENSPTRG00000008324|UniProtKB=H2QBH3	Uncharacterized protein	ISS			PTHR11751:SF368	TYROSINE AMINOTRANSFERASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	STRPU|EnsemblGenome=SPU_023123|UniProtKB=W4Z4S0	Glutamine synthetase	ISS			PTHR20852:SF57	GLUTAMINE SYNTHETASE 2 CYTOPLASMIC
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ORNAN|Ensembl=ENSOANG00000007716|UniProtKB=F6UDX9	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=96276|UniProtKB=Q61224	5-hydroxytryptamine receptor 1D	IDA	12441358	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00059	p53 pathway	P04609	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	PLAF7|EnsemblGenome=PFI1090w|UniProtKB=Q7K6A4	S-adenosylmethionine synthase	ISS			PTHR11964:SF1	S-ADENOSYLMETHIONINE SYNTHASE
P00047	PDGF signaling pathway	P01160	IP3 receptor	CAEBR|Gene=CBG_05938|UniProtKB=H8WGV2	Protein CBR-ITR-1, isoform a	ISS	4262086	gi	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00303	c-Jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	8837781	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01072	CHT1	ANOGA|EnsemblGenome=AGAP002366|UniProtKB=Q7QBY8	AGAP002366-PA	ISS	12675135	PubMed	PTHR11819:SF12	HIGH-AFFINITY CHOLINE TRANSPORTER 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00034	Integrin signalling pathway	P00912	Arp2/3	RAT|RGD=2155|UniProtKB=O88656	Actin-related protein 2/3 complex subunit 1B	IPI	12963527	gi	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00006	Apoptosis signaling pathway	P00260	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01465	Ggamma	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00005	Angiogenesis	P00217	STAT3	MOUSE|MGI=MGI=103038|UniProtKB=P42227	Signal transducer and activator of transcription 3	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	MOUSE|MGI=MGI=88398|UniProtKB=Q9ERZ3	Muscarinic acetylcholine receptor M3	ISS	12181435	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00005	Angiogenesis	P00217	STAT3	MOUSE|MGI=MGI=103038|UniProtKB=P42227	Signal transducer and activator of transcription 3	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00573	signal peptidase	RAT|RGD=69360|UniProtKB=P42667	Signal peptidase complex catalytic subunit SEC11A	ISS	2674115	PubMed	PTHR10806:SF8	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11A-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00006	Apoptosis signaling pathway	P00307	ELF2alpha	ARATH|TAIR=AT5G05470|UniProtKB=Q9FE78	AT5g05470	ISS			PTHR10602:SF0	EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1
P00057	Wnt signaling pathway	P01472	Histone deacetylase	CHICK|Ensembl=ENSGALG00000004825|UniProtKB=F1NFY6	Histone deacetylase	ISS	10485845	PubMed	PTHR10625:SF142	HISTONE DEACETYLASE 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01147	Nck	MOUSE|MGI=MGI=109601|UniProtKB=Q99M51	Cytoplasmic protein NCK1	ISS	12874226	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00034	Integrin signalling pathway	P00924	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P02770	Pyridoxal phosphate salvage pathway	P03120	Pyridoxamine-5-phosphate oxidase	MYCTU|EnsemblGenome=Rv2607|UniProtKB=P9WIJ1	Pyridoxine/pyridoxamine 5'-phosphate oxidase	ISS	9634230	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	BOVIN|Ensembl=ENSBTAG00000013555|UniProtKB=F1MSQ2	Receptor protein serine/threonine kinase	ISS	10683140	PubMed	PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P00012	Cadherin signaling pathway	P00474	Wnt	DANRE|ZFIN=ZDB-GENE-081003-1|UniProtKB=B0LK22	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00005	Angiogenesis	P00219	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MACMU|Ensembl=ENSMMUG00000009341|UniProtKB=F6UA54	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	RAT|RGD=2736|UniProtKB=P35439	Glutamate receptor ionotropic, NMDA 1	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00018	EGF receptor signaling pathway	P00545	JNK1-3	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00054	Toll receptor signaling pathway	P01375	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	XENTR|Xenbase=XB-GENE-484012|UniProtKB=F6R871	Serine/threonine-protein kinase receptor	ISS	11252892	PubMed	PTHR23255:SF64	ACTIVIN RECEPTOR TYPE-2A
P00052	TGF-beta signaling pathway	P01292	RSmads	BOVIN|Gene=SMAD2|UniProtKB=Q1W668	Mothers against decapentaplegic homolog 2	ISS	9395284	PubMed	PTHR13703:SF42	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1170702	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00017	DNA replication	P00530	Top	MACMU|Ensembl=ENSMMUG00000007371|UniProtKB=F7E5A9	DNA topoisomerase 2	RCA			PTHR10169:SF36	DNA TOPOISOMERASE 2-BETA
P00034	Integrin signalling pathway	P00920	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00057	Wnt signaling pathway	P01457	GBeta	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P05730	Endogenous cannabinoid signaling	P05748	mGluR	MOUSE|MGI=MGI=1351338|UniProtKB=P97772	Metabotropic glutamate receptor 1	ISS	9407094	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-478663|UniProtKB=F7EG64	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04393	Ras Pathway	P04567	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00020	FAS signaling pathway	P00615	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00017	DNA replication	P00527	Histones	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g159483|UniProtKB=A7RJG4	Predicted protein	ISS	20448842	PubMed	PTHR11426:SF169	HISTONE H3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	MOUSE|MGI=MGI=1351339|UniProtKB=Q14BI2	Metabotropic glutamate receptor 2	ISS	12488551	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IDA	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00046	Oxidative stress response	P01129	JNK1/2	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00048	PI3 kinase pathway	P01199	Galpha	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P06587	Nicotine pharmacodynamics pathway	P06601	FLNA	CANLF|Ensembl=ENSCAFG00000019521|UniProtKB=F1PWW0	Uncharacterized protein	ISS	11911837	PubMed	PTHR43998:SF6	FILAMIN-A
P00006	Apoptosis signaling pathway	P00310	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	IDA	91056091	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00006	Apoptosis signaling pathway	P00321	HSP70	SCHPO|PomBase=SPCC1739.13|UniProtKB=O59855	Probable heat shock protein ssa2	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P05917	Opioid proopiomelanocortin pathway	P06010	proopiomelanocortin	XENTR|Xenbase=XB-GENE-483703|UniProtKB=Q5M8F2	Proopiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00005	Angiogenesis	P00252	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8235613	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	RAT|RGD=2869|UniProtKB=P24062	Insulin-like growth factor 1 receptor	ISS	2877871	PubMed	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00010	B cell activation	P00398	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	PHYPA|Gene=PHYPADRAFT_198730|UniProtKB=Q6TYS2	Actin 1	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00053	T cell activation	P01324	rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00004	Alzheimer disease-presenilin pathway	P00147	TACE	MOUSE|MGI=MGI=1096335|UniProtKB=Q9Z0F8	Disintegrin and metalloproteinase domain-containing protein 17	TAS	9774383	PubMed	PTHR11905:SF171	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17
P00021	FGF signaling pathway	P00629	PP2A	CHICK|Ensembl=ENSGALG00000010273|UniProtKB=P48463	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	2461222	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000020224|UniProtKB=H2Q9G3	Mitogen-activated protein kinase 6	ISS	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00006	Apoptosis signaling pathway	P00274	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00633	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IGI	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P06587	Nicotine pharmacodynamics pathway	P06595	CHRNA3	MACMU|Ensembl=ENSMMUG00000023736|UniProtKB=F7G778	Uncharacterized protein	ISS	12098588	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P00005	Angiogenesis	P00219	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	HUMAN|HGNC=7881|UniProtKB=P46531	Neurogenic locus notch homolog protein 1	IDA	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	PANTR|Ensembl=ENSPTRG00000017391|UniProtKB=D3K5P1	Adrenergic, beta-2-, receptor, surface	ISS	12063255	PubMed	PTHR24248:SF21	BETA-2 ADRENERGIC RECEPTOR
P00021	FGF signaling pathway	P00632	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IGI	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06007	alpha-MSH	DANRE|ZFIN=ZDB-GENE-030513-2|UniProtKB=Q7ZT18	Pro-opiomelanocortin protein	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BRAFL|Gene=BRAFLDRAFT_220697|UniProtKB=C3ZSF0	Putative uncharacterized protein	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IGI	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	RAT|RGD=70958|UniProtKB=P19492	Glutamate receptor 3	ISS	12871085	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00049	Parkinson disease	P01211	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	IDA	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	TAS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CHICK|Ensembl=ENSGALG00000011809|UniProtKB=F1NMB0	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00021	FGF signaling pathway	P00634	MEKK1-5	BOVIN|Ensembl=ENSBTAG00000004216|UniProtKB=F1MSX4	Uncharacterized protein	ISS	8621389	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ORYSJ|EnsemblGenome=OS02G0148100|UniProtKB=Q6Z437	Mitogen-activated protein kinase 3	ISS	9836510	gi	PTHR24055:SF216	SUBFAMILY NOT NAMED
P05731	GABA-B receptor II signaling	P05754	Ggamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	RCA	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000008536|UniProtKB=F6WBZ5	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00059	p53 pathway	P04635	Sumo-1 ligase	MOUSE|MGI=MGI=1197010|UniProtKB=P63166	Small ubiquitin-related modifier 1	ISS			PTHR10562:SF52	SMALL UBIQUITIN-RELATED MODIFIER 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CIOIN|Ensembl=ENSCING00000000848|UniProtKB=F6SCP4	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00759	PDEalphabeta	RAT|RGD=1306835|UniProtKB=D3Z8C9	Phosphodiesterase	ISS	P27664	SPACC	PTHR11347:SF115	ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01425	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00029	Huntington disease	P00775	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12676940	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00036	Interleukin signaling pathway	P00983	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00637	MKK4,7	BOVIN|Ensembl=ENSBTAG00000012103|UniProtKB=A5PJP8	MAP2K4 protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06779	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	RCA	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00996	STAT	CANLF|Ensembl=ENSCAFG00000015346|UniProtKB=E2RE22	Signal transducer and activator of transcription	ISS	14662325	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00021	FGF signaling pathway	P00628	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00797	p53	DANRE|ZFIN=ZDB-GENE-030819-1|UniProtKB=E9QG65	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P04398	p53 pathway feedback loops 2	P04661	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	10799299	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P05913	Enkephalin release	P05974	G-Protein (i)	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P02747	Histidine biosynthesis	P02991	Histidinephosphate aminotransferase	YEAST|SGD=S000001378|UniProtKB=P07172	Histidinol-phosphate aminotransferase	ISS			PTHR42885:SF2	HISTIDINOL-PHOSPHATE AMINOTRANSFERASE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	SCHMA|EnsemblGenome=Smp_079970|UniProtKB=G4VTA5	Putative tubulin beta chain	ISS	12932731	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P04398	p53 pathway feedback loops 2	P04665	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00633	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IGI	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00018	EGF receptor signaling pathway	P00558	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	IGI	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00012	Cadherin signaling pathway	P00470	F-actin	CHICK|Ensembl=ENSGALG00000014620|UniProtKB=F1N8P3	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00938	Cdc42	XENTR|Xenbase=XB-GENE-967585|UniProtKB=Q28BZ0	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P02788	Xanthine and guanine salvage pathway	P03248	Deoxyguanosine phosphorylase	CAEEL|WormBase=WBGene00019298|UniProtKB=U4PSA1	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00054	Toll receptor signaling pathway	P01378	IRAKM	MACMU|Ensembl=ENSMMUG00000016625|UniProtKB=F6TPI1	Uncharacterized protein	ISS			PTHR24419:SF7	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 3
P00010	B cell activation	P00402	Jnk	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MACMU|Ensembl=ENSMMUG00000010987|UniProtKB=F7GCX9	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IGI	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	RAT|RGD=1310389|UniProtKB=D3ZTF6	Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Predicted), isoform CRA_a	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00056	VEGF signaling pathway	P01423	p38MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00049	Parkinson disease	P01219	SAPK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MOUSE|MGI=MGI=1921442|UniProtKB=Q9D898	Actin-related protein 2/3 complex subunit 5-like protein	ISS			PTHR12644:SF2	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5-LIKE PROTEIN
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	DANRE|ZFIN=ZDB-GENE-020125-5|UniProtKB=A2CG69	Uncharacterized protein	ISS	20112749	PubMed	PTHR18966:SF356	SUBFAMILY NOT NAMED
P05913	Enkephalin release	P05977	G-Protein (s)	DANRE|ZFIN=ZDB-GENE-041114-26|UniProtKB=F1RE11	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00053	T cell activation	P01322	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00238	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	HUMAN|HGNC=6693|UniProtKB=Q9NZR2	Low-density lipoprotein receptor-related protein 1B	IDA	11907044	PubMed	PTHR44025:SF7	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	CAEEL|WormBase=WBGene00000392|UniProtKB=Q20628	CytiDine Deaminase	ISS			PTHR11644:SF2	CYTIDINE DEAMINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=94924|UniProtKB=P61168	D(2) dopamine receptor	IDA	11861492	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00056	VEGF signaling pathway	P01413	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	ISS	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DROME|FlyBase=FBgn0259680|UniProtKB=P83099	Putative protein kinase C delta type homolog	ISS	3755548	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00020	FAS signaling pathway	P00622	FADD	RAT|RGD=628700|UniProtKB=Q8R2E7	FAS-associated death domain protein	IGI	9506948	PubMed	PTHR15077:SF8	FAS-ASSOCIATED DEATH DOMAIN PROTEIN
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00642	MEK1-2	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00059	p53 pathway	P04633	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Ensembl=ENSCAFG00000004256|UniProtKB=E2RR18	Serine/threonine-protein kinase	ISS	11062248	PubMed	PTHR22968:SF12	SERINE/THREONINE-PROTEIN KINASE D2
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	IC	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00001	Adrenaline and noradrenaline biosynthesis	P00070	VAT2	PANTR|Ensembl=ENSPTRG00000002979|UniProtKB=H2Q2M8	Uncharacterized protein	ISS	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00034	Integrin signalling pathway	P00920	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	PANTR|Ensembl=ENSPTRG00000010386|UniProtKB=H2QF61	Tyrosine-protein kinase receptor	ISS	14500580	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05915	Opioid proenkephalin pathway	P05994	G-protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	CANLF|Ensembl=ENSCAFG00000004882|UniProtKB=F1PAE3	Uncharacterized protein	ISS	14698990	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00047	PDGF signaling pathway	P01153	GSK3	CIOIN|Ensembl=ENSCING00000001821|UniProtKB=Q9NL43	Glycogen synthase kinase	ISS	21361340	gi	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00005	Angiogenesis	P00233	CSL	CIOIN|Ensembl=ENSCING00000000838|UniProtKB=O76808	Suppressor of hairless homolog	ISS			PTHR10665:SF0	SUPPRESSOR OF HAIRLESS PROTEIN
P02744	Fructose galactose metabolism	P02960	Galactokinase	CANLF|Ensembl=ENSCAFG00000014895|UniProtKB=E2RDA6	Uncharacterized protein	ISS			PTHR10457:SF7	N-ACETYLGALACTOSAMINE KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	TAS	10799299	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P05913	Enkephalin release	P05972	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	BOVIN|Ensembl=ENSBTAG00000018445|UniProtKB=E1BK87	Uncharacterized protein	ISS	14698601	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00046	Oxidative stress response	P01134	cPLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00021	FGF signaling pathway	P00643	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	CANLF|Ensembl=ENSCAFG00000001239|UniProtKB=E2RFN3	Uncharacterized protein	ISS			PTHR13218:SF8	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CANLF|Ensembl=ENSCAFG00000004381|UniProtKB=J9JH96	Uncharacterized protein	ISS			PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	RAT|RGD=71027|UniProtKB=P42264	Glutamate receptor ionotropic, kainate 3	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00034	Integrin signalling pathway	P00927	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00018	EGF receptor signaling pathway	P00565	PKC	SCHPO|PomBase=SPAC17G8.14c|UniProtKB=P36582	Protein kinase C-like 1	IGI	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	PANTR|Ensembl=ENSPTRG00000001609|UniProtKB=H2R8G6	Regulator of G-protein signaling 5	ISS	8756726	PubMed	PTHR10845:SF42	REGULATOR OF G-PROTEIN SIGNALING 5
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01451	Galpha	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	HUMAN|HGNC=1388|UniProtKB=O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	11976940	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=11429|UniProtKB=O75558	Syntaxin-11	IC	11067767	PubMed	PTHR19957:SF30	SYNTAXIN-11
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	MACMU|Ensembl=ENSMMUG00000010173|UniProtKB=F7AGU8	Presenilin	ISS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	PANTR|Ensembl=ENSPTRG00000011718|UniProtKB=H2QHJ5	Adenylate cyclase 3	ISS	2255909	PubMed	PTHR11920:SF291	ADENYLATE CYCLASE TYPE 3
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06773	gnai/o	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P06959	CCKR signaling map	P07202	SRC	HUMAN|HGNC=11283|UniProtKB=P12931	Proto-oncogene tyrosine-protein kinase Src	RCA	11376654	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00059	p53 pathway	P04635	Sumo-1 ligase	PANTR|Ensembl=ENSPTRG00000013991|UniProtKB=H2QL52	Small ubiquitin-related modifier	ISS			PTHR10562:SF50	SMALL UBIQUITIN-RELATED MODIFIER 3
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IPI	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00049	Parkinson disease	P01242	Casein kinase I	MOUSE|MGI=MGI=1351660|UniProtKB=Q9JMK2	Casein kinase I isoform epsilon	IDA	11865049	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	RAT|RGD=2518|UniProtKB=P18901	D(1A) dopamine receptor	ISS	11861492	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000018059|UniProtKB=C7G3M9	Glutamate receptor, metabotropic 4	ISS	12488551	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00025	Hedgehog signaling pathway	P00682	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00920	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	IPI	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P06664	Gonadotropin-releasing hormone receptor pathway	P06701	TCF	MOUSE|MGI=MGI=1202876|UniProtKB=Q9Z1J1	Transcription factor 7-like 1	RCA	12356903	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	RAT|RGD=1309504|UniProtKB=D3ZRN3	Protein Actbl2	ISS	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00012	Cadherin signaling pathway	P00470	F-actin	TAKRU|Ensembl=ENSTRUG00000005447|UniProtKB=P68142	Actin, cytoplasmic 1	IC	11889126	PubMed	PTHR11937:SF354	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000022175|UniProtKB=F6XHY0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00012	Cadherin signaling pathway	P00474	Wnt	RAT|RGD=1307644|UniProtKB=D3ZND6	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04578	Rho	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	IDA	11360179	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00463	betacatenin	CANLF|Ensembl=ENSCAFG00000005204|UniProtKB=B6V8E6	Catenin beta-1	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=107451|UniProtKB=Q8K2J0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3	ISS	12860966	PubMed	PTHR10336:SF33	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-3
P00057	Wnt signaling pathway	P01465	Ggamma	MONDO|Ensembl=ENSMODG00000000771|UniProtKB=F6SSS3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IGI	14526383	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	PANTR|Ensembl=ENSPTRG00000003699|UniProtKB=H2Q3R5	Syntaxin 3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00023	General transcription regulation	P00658	TBP-associated factors	RAT|RGD=1309935|UniProtKB=B0BN78	Protein Taf7	ISS			PTHR12228:SF6	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 7
P00007	Axon guidance mediated by semaphorins	P00336	Cdk5	RAT|RGD=70514|UniProtKB=Q03114	Cyclin-dependent-like kinase 5	ISS			PTHR24056:SF46	CYCLIN-DEPENDENT-LIKE KINASE 5
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	IC	91072385	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00029	Huntington disease	P00774	Dynein complex	MOUSE|MGI=MGI=1915347|UniProtKB=Q9D0M5	Dynein light chain 2, cytoplasmic	IPI	9454836	PubMed	PTHR11886:SF35	DYNEIN LIGHT CHAIN 2, CYTOPLASMIC
P00059	p53 pathway	P01486	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02783	Tryptophan biosynthesis	P03208	Tryptophan synthase B	SCHPO|PomBase=SPAC19A8.15|UniProtKB=O13831	Tryptophan synthase	ISS			PTHR42882:SF1	TRYPTOPHAN SYNTHASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	TAS	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00059	p53 pathway	P04631	P21	HUMAN|HGNC=1784|UniProtKB=P38936	Cyclin-dependent kinase inhibitor 1	ISS			PTHR10265:SF16	CYCLIN-DEPENDENT KINASE INHIBITOR 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	MONDO|Ensembl=ENSMODG00000001583|UniProtKB=F7BBM1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P02775	Salvage pyrimidine ribonucleotides	P03153	Cytidylate kinase	DICDI|dictyBase=DDB_G0287495|UniProtKB=P20425	UMP-CMP kinase	ISS			PTHR23359:SF107	UMP-CMP KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MACMU|Ensembl=ENSMMUG00000014762|UniProtKB=F7G0R4	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF344	MYOSIN-7
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	P00548	RKIP	ORYSJ|EnsemblGenome=OS01G0111600|UniProtKB=Q9ASJ1	Protein MOTHER of FT and TFL1 homolog 2	ISS			PTHR11362:SF42	SUBFAMILY NOT NAMED
P02728	Arginine biosynthesis	P02841	argininosuccinate lyase	MOUSE|MGI=MGI=88084|UniProtKB=Q91YI0	Argininosuccinate lyase	ISS			PTHR43814:SF1	ARGININOSUCCINATE LYASE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	ISS	12805548	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00054	Toll receptor signaling pathway	P01338	IkappaB	MOUSE|MGI=MGI=104741|UniProtKB=Q9Z1E3	NF-kappa-B inhibitor alpha	ISS	14665694	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IC	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00643	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00642	MEK1-2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00038	JAK/STAT signaling pathway	P01033	PTP	HUMAN|HGNC=9666|UniProtKB=P08575	Receptor-type tyrosine-protein phosphatase C	ISS	8940015	PubMed	PTHR19134:SF284	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01358	ERK1	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	TAS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01438	PP2A	RAT|RGD=6503701|UniProtKB=F1MAA3	Protein LOC100909464	ISS	96161994	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00034	Integrin signalling pathway	P00948	Rho	PANTR|Ensembl=ENSPTRG00000012527|UniProtKB=H2R6I3	Rho family GTPase 3	ISS	11973360	PubMed	PTHR24072:SF24	RHO-RELATED GTP-BINDING PROTEIN RHOE
P00057	Wnt signaling pathway	P01444	Wnt	TAKRU|Ensembl=ENSTRUG00000000172|UniProtKB=H2RJP1	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF103	PROTEIN WNT-4A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	DANRE|ZFIN=ZDB-GENE-010614-1|UniProtKB=Q9PTF7	Chemokine receptor CXCR4	ISS	4503175	gi	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00035	Interferon-gamma signaling pathway	P00954	Interferongamma	CANLF|Ensembl=ENSCAFG00000000408|UniProtKB=P42161	Interferon gamma	TAS	11175845	PubMed	PTHR11419:SF0	INTERFERON GAMMA
P00005	Angiogenesis	P00203	Erk	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ARATH|TAIR=AT1G07880|UniProtKB=Q9LQQ9	Mitogen-activated protein kinase 13	IDA			PTHR24055:SF185	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05913	Enkephalin release	P05977	G-Protein (s)	CHICK|Ensembl=ENSGALG00000027629|UniProtKB=Q5ZJ03	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	2837282	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00034	Integrin signalling pathway	P00912	Arp2/3	PANTR|Ensembl=ENSPTRG00000012911|UniProtKB=H2QJE2	Uncharacterized protein	ISS	12473693	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00010	B cell activation	P00381	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MONDO|Ensembl=ENSMODG00000018204|UniProtKB=F6PGX6	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00004	Alzheimer disease-presenilin pathway	P00110	Ire-1 N-terminal fragment	ARATH|TAIR=AT3G11870|UniProtKB=Q9SF12	Inactive serine/threonine-protein kinase/endoribonuclease IRE1-like	IDA	10619423	PubMed	PTHR13954:SF6	INOSITOL-REQUIRING ENZYME-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00018	EGF receptor signaling pathway	P00558	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P06211	BMP/activin signaling pathway-drosophila	P06243	Smurf	DROME|FlyBase=FBgn0029006|UniProtKB=Q9V853	E3 ubiquitin-protein ligase Smurf1	RCA	11252892	PubMed	PTHR11254:SF395	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P00020	FAS signaling pathway	P00601	c-Jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	12972619	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00047	PDGF signaling pathway	P01143	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IGI	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	ORNAN|Ensembl=ENSOANG00000002061|UniProtKB=F7ANC6	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00021	FGF signaling pathway	P00634	MEKK1-5	PANTR|Ensembl=ENSPTRG00000024326|UniProtKB=H2R231	Uncharacterized protein	ISS	8974401	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00059	p53 pathway	P04609	PI3K	CANAL|CGD=CAL0068551|UniProtKB=Q5AAR9	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00750	Rhodopsin kinase	DANRE|ZFIN=ZDB-GENE-050823-1|UniProtKB=Q1XHM0	Rhodopsin kinase	ISS	8260489	PubMed	PTHR24355:SF11	RHODOPSIN KINASE
P00007	Axon guidance mediated by semaphorins	P00331	PAK	BOVIN|Ensembl=ENSBTAG00000010191|UniProtKB=Q08E52	Serine/threonine-protein kinase PAK 1	ISS	14580336	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00034	Integrin signalling pathway	P00936	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CAEEL|WormBase=WBGene00000067|UniProtKB=O45815	ACTin	IDA	3487386	PubMed	PTHR11937:SF352	ACTIN
P00047	PDGF signaling pathway	P01165	SRF	DROME|FlyBase=FBgn0004101|UniProtKB=Q24535	Serum response factor homolog	ISS			PTHR11945:SF221	SERUM RESPONSE FACTOR
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00059	p53 pathway	G04699	BAI-1	HUMAN|HGNC=944|UniProtKB=O60241	Adhesion G protein-coupled receptor B2	ISS			PTHR12011:SF41	ADHESION G PROTEIN-COUPLED RECEPTOR B2
P00018	EGF receptor signaling pathway	P00562	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	ISS	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04452	proopiomelanocortin	DANRE|ZFIN=ZDB-GENE-041014-294|UniProtKB=Q5SPP4	Uncharacterized protein	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P05916	Opioid prodynorphin pathway	P06002	G-protein	ANOGA|EnsemblGenome=AGAP005911|UniProtKB=Q7Q6D4	AGAP005911-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04393	Ras Pathway	P04557	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04393	Ras Pathway	P04547	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IDA	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	12707323	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_126324|UniProtKB=C3XYC2	Putative uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	BOVIN|Ensembl=ENSBTAG00000011579|UniProtKB=F1N5C5	Muscarinic acetylcholine receptor	ISS	8100450	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00021	FGF signaling pathway	P00628	JNK1-3	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IGI	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00049	Parkinson disease	P01238	14-3-3	CHICK|Ensembl=ENSGALG00000004143|UniProtKB=Q5ZLQ6	14-3-3 protein beta/alpha	ISS	10407019	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	MONDO|Ensembl=ENSMODG00000019523|UniProtKB=F6VCI6	Uncharacterized protein	ISS	10617630	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MACMU|Ensembl=ENSMMUG00000015904|UniProtKB=F7ATF8	Uncharacterized protein	ISS	12356903	PubMed	PTHR24082:SF15	PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DELTA
P00049	Parkinson disease	P01211	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06852	nPKCs	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00056	VEGF signaling pathway	P01417	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	IC	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00046	Oxidative stress response	P01135	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	TAS	7937853	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00006	Apoptosis signaling pathway	P00316	Bcl-w	MOUSE|MGI=MGI=108052|UniProtKB=P70345	Bcl-2-like protein 2	ISS	10366024	PubMed	PTHR11256:SF13	BCL-2-LIKE PROTEIN 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	IC	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00014	Cholesterol biosynthesis	P00496	Diphosphomevalonate decarboxylase	MACMU|Ensembl=ENSMMUG00000014326|UniProtKB=F7D4H8	Diphosphomevalonate decarboxylase	ISS	4505289	gi	PTHR10977:SF3	DIPHOSPHOMEVALONATE DECARBOXYLASE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00006	Apoptosis signaling pathway	P00321	HSP70	ORYSJ|EnsemblGenome=OS05G0460000|UniProtKB=Q6L509	Os05g0460000 protein	ISS	12150907	PubMed	PTHR19375:SF255	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 37C-RELATED
P00011	Blood coagulation	P00444	FIX	HUMAN|HGNC=3551|UniProtKB=P00740	Coagulation factor IX	ISS	14270099	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P02762	Pentose phosphate pathway	P03079	Hexokinase	HUMAN|HGNC=4922|UniProtKB=P19367	Hexokinase-1	RCA			PTHR19443:SF10	HEXOKINASE-1
P00050	Plasminogen activating cascade	P01245	PAI-1	PANTR|Ensembl=ENSPTRG00000019519|UniProtKB=H2QV47	Uncharacterized protein	ISS	18092159	gi	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P04393	Ras Pathway	P04548	ATF2	MOUSE|MGI=MGI=109349|UniProtKB=P16951	Cyclic AMP-dependent transcription factor ATF-2	IDA	10207617	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P02788	Xanthine and guanine salvage pathway	P03249	Guanine deaminase	MOUSE|MGI=MGI=95678|UniProtKB=Q9R111	Guanine deaminase	ISS	11837778	gi	PTHR11271:SF6	GUANINE DEAMINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	MACMU|Ensembl=ENSMMUG00000018476|UniProtKB=F6X938	Uncharacterized protein	RCA			PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	RAT|RGD=2026|UniProtKB=P68035	Actin, alpha cardiac muscle 1	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00029	Huntington disease	P00810	GAPDH	CANLF|Gene=GAPDH|UniProtKB=Q28259	Glyceraldehyde-3-phosphate dehydrogenase	ISS	8612237	PubMed	PTHR10836:SF51	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00005	Angiogenesis	P00206	Wnt	BOVIN|Ensembl=ENSBTAG00000020221|UniProtKB=E1BDG5	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00034	Integrin signalling pathway	P00922	Collagen	BOVIN|Ensembl=ENSBTAG00000013155|UniProtKB=P02459	Collagen alpha-1(II) chain	ISS	10778855	PubMed	PTHR24023:SF58	COLLAGEN ALPHA-1 II  CHAIN
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00029	Huntington disease	P00779	TBP	ANOGA|EnsemblGenome=AGAP010958|UniProtKB=Q7PFI3	AGAP010958-PA	IPI	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00029	Huntington disease	P00807	Actin	TAKRU|Ensembl=ENSTRUG00000014318|UniProtKB=H2UI49	Uncharacterized protein	IDA	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00029	Huntington disease	P00776	c-Jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000014751|UniProtKB=H2R8D8	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00034	Integrin signalling pathway	P00924	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00050	Plasminogen activating cascade	P01244	PAI-2	PANTR|Ensembl=ENSPTRG00000023897|UniProtKB=H2QEN1	Uncharacterized protein	ISS	11929770	PubMed	PTHR11461:SF61	PLASMINOGEN ACTIVATOR INHIBITOR 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00011	Blood coagulation	P00439	Prekallikrein	MOUSE|MGI=MGI=102849|UniProtKB=P26262	Plasma kallikrein	ISS	20072342	gi	PTHR44459:SF2	PLASMA KALLIKREIN
P00056	VEGF signaling pathway	P01406	VEGF	HUMAN|HGNC=12680|UniProtKB=P15692	Vascular endothelial growth factor A	ISS			PTHR12025:SF5	VASCULAR ENDOTHELIAL GROWTH FACTOR A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00790	beta-Tubulin	CAEEL|WormBase=WBGene00006536|UniProtKB=O17921	TuBulin, Beta	TAS	9454836	PubMed	PTHR11588:SF157	TUBULIN, BETA
P00059	p53 pathway	G04694	p110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01227	20S proteasome	GIAIC|EnsemblGenome=GL50803_14497|UniProtKB=E2RTW7	20S proteasome alpha subunit 3	TAS	12859888	PubMed	PTHR11599:SF13	PROTEASOME SUBUNIT ALPHA TYPE-4
P00053	T cell activation	P01312	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05731	GABA-B receptor II signaling	P05754	Ggamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	RCA	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	XENTR|Xenbase=XB-GENE-1004371|UniProtKB=F6R882	Uncharacterized protein	ISS			PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00034	Integrin signalling pathway	P00945	Parvin	HUMAN|HGNC=14653|UniProtKB=Q9HBI1	Beta-parvin	IPI	11331308	PubMed	PTHR12114:SF7	BETA-PARVIN
P04375	5HT3 type receptor mediated signaling pathway	P04425	K+ channel	BOVIN|Ensembl=ENSBTAG00000047488|UniProtKB=G3N1D1	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00629	PP2A	RAT|RGD=1308022|UniProtKB=D3ZDI7	Protein Ppp2r5a	ISS	10092233	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01242	Casein kinase I	LEIMA|EnsemblGenome=LmjF.35.1010|UniProtKB=Q9NHE1	Casein kinase 1 isoform 2	IDA	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02918	dUTP pyrophosphatase	ECOLI|EcoGene=EG10251|UniProtKB=P06968	Deoxyuridine 5'-triphosphate nucleotidohydrolase	ISS			PTHR11241:SF0	BCDNA.LD08534
P00034	Integrin signalling pathway	P00927	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12874273	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00045	Notch signaling pathway	P01109	Aph-1	MOUSE|MGI=MGI=3522097|UniProtKB=Q8C7N7	Gamma-secretase subunit APH-1B	ISS	12110170	PubMed	PTHR12889:SF1	GAMMA-SECRETASE SUBUNIT APH-1B
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00021	FGF signaling pathway	P00641	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00019	Endothelin signaling pathway	P00570	PKA	YEAST|SGD=S000001295|UniProtKB=P07278	cAMP-dependent protein kinase regulatory subunit	ISS	176892	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	PANTR|Ensembl=ENSPTRG00000022187|UniProtKB=Q7YQL4	Serine/threonine-protein kinase PAK 3	ISS	7559398	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00021	FGF signaling pathway	P00629	PP2A	DICDI|dictyBase=DDB_G0283601|UniProtKB=Q54QR9	Serine/threonine-protein phosphatase 2A regulatory subunit pppA	ISS			PTHR10648:SF4	PROTEIN PHOSPHATASE 2  FORMERLY 2A , REGULATORY SUBUNIT A, BETA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=4401|UniProtKB=O14775	Guanine nucleotide-binding protein subunit beta-5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00021	FGF signaling pathway	P00634	MEKK1-5	BOVIN|Ensembl=ENSBTAG00000009065|UniProtKB=F1MXH6	Uncharacterized protein	ISS	12566458	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000001384|UniProtKB=F7GL73	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IGI	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00053	T cell activation	P01336	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=1921982|UniProtKB=Q9D3G5	Syntaxin-11	IC	11067767	PubMed	PTHR19957:SF30	SYNTAXIN-11
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00048	PI3 kinase pathway	P01185	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MOUSE|MGI=MGI=2152453|UniProtKB=Q2NL51	Glycogen synthase kinase-3 alpha	ISS	14698990	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P02775	Salvage pyrimidine ribonucleotides	P03156	CDP kinase	ARATH|TAIR=AT5G40870|UniProtKB=Q9FKS0	Uridine kinase-like protein 1, chloroplastic	ISS			PTHR10285:SF70	URIDINE-CYTIDINE KINASE 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00056	VEGF signaling pathway	P01405	VRAP	MACMU|Ensembl=ENSMMUG00000010917|UniProtKB=F7GLS8	Uncharacterized protein	ISS	10692392	PubMed	PTHR14388:SF9	SH2 DOMAIN-CONTAINING PROTEIN 2A
P00034	Integrin signalling pathway	P00906	Rap1	HUMAN|HGNC=9857|UniProtKB=P61224	Ras-related protein Rap-1b	IPI	10476970	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P02770	Pyridoxal phosphate salvage pathway	P03122	Pyridoxamine kinase	PANTR|Ensembl=ENSPTRG00000040962|UniProtKB=H2RGH3	Pyridoxal (Pyridoxine, vitamin B6) kinase	ISS	15082224	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00006	Apoptosis signaling pathway	P00307	ELF2alpha	DROME|FlyBase=FBgn0261609|UniProtKB=P41374	Eukaryotic translation initiation factor 2 subunit 1	ISS			PTHR10602:SF0	EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	RCA	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00036	Interleukin signaling pathway	P00965	ERK	RAT|RGD=621505|UniProtKB=P0C865	Mitogen-activated protein kinase 7	ISS	15085193	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	TAS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00009	Axon guidance mediated by netrin	P00364	cdc42	ANOGA|EnsemblGenome=AGAP002440|UniProtKB=Q17031	Cdc42 homolog	ISS	12932731	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00987	SRF	MACMU|Ensembl=ENSMMUG00000000033|UniProtKB=F7G4D2	Uncharacterized protein	ISS	8660892	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00047	PDGF signaling pathway	P01154	Ras	DICPU|Gene=DICPUDRAFT_92731|UniProtKB=F0ZWE6	Putative uncharacterized protein rasG	ISS	89128893	PubMed	PTHR24070:SF282	RAS GTPASE-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	ANOGA|EnsemblGenome=AGAP001394|UniProtKB=F5HMS4	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00551	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00029	Huntington disease	P00790	beta-Tubulin	BOVIN|Ensembl=ENSBTAG00000025274|UniProtKB=Q3MHM5	Tubulin beta-4B chain	ISS	9454836	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	11535291	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00107	kinesin	BOVIN|Ensembl=ENSBTAG00000017299|UniProtKB=A6H7H2	KLC1 protein	ISS	11740561	PubMed	PTHR19959:SF203	KINESIN LIGHT CHAIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DROME|FlyBase=FBgn0001105|UniProtKB=P26308	Guanine nucleotide-binding protein subunit beta-1	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00624	14-3-3	DANRE|ZFIN=ZDB-GENE-011115-1|UniProtKB=Q6PC29	14-3-3 protein gamma-1	ISS	8381897	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00057	Wnt signaling pathway	P01451	Galpha	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04372	5-Hydroxytryptamine degredation	P04401	Monoamine Oxidase	RAT|RGD=3041|UniProtKB=P19643	Amine oxidase [flavin-containing] B	ISS	8602220	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	CHICK|Ensembl=ENSGALG00000007509|UniProtKB=F1NM72	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00057	Wnt signaling pathway	P01448	CBP	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	RAT|RGD=1359133|UniProtKB=Q6AY07	Fructose-bisphosphate aldolase	ISS	84261525	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	PSEAE|EnsemblGenome=PA5549|UniProtKB=Q9HT25	Glutamine--fructose-6-phosphate aminotransferase [isomerizing]	ISS			PTHR10937:SF0	GH12731P-RELATED
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8685|UniProtKB=Q9Y5E9	Protocadherin beta-14	IDA	8120095	PubMed	PTHR24028:SF81	PROTOCADHERIN BETA-14
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04393	Ras Pathway	P04548	ATF2	MONDO|Ensembl=ENSMODG00000009514|UniProtKB=F7EVK3	Uncharacterized protein	ISS	10487205	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000035697|UniProtKB=Q28024	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05731	GABA-B receptor II signaling	P05754	Ggamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	RCA	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01188	Gbetagamma	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00005	Angiogenesis	P00189	Fzd	BOVIN|Ensembl=ENSBTAG00000020590|UniProtKB=G3N2W8	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF34	FRIZZLED-2
P02771	Pyrimidine Metabolism	P03128	Dihydrouracil Dehydrogenase	MOUSE|MGI=MGI=2139667|UniProtKB=Q8CHR6	Dihydropyrimidine dehydrogenase [NADP(+)]	ISS	8083224	PubMed	PTHR43073:SF2	DIHYDROPYRIMIDINE DEHYDROGENASE  NADP +
P00048	PI3 kinase pathway	P01179	PKB	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00233	CSL	PANTR|Ensembl=ENSPTRG00000013542|UniProtKB=H2QKF3	Uncharacterized protein	ISS			PTHR10665:SF2	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS-LIKE PROTEIN
P00049	Parkinson disease	P01228	DAT	MACMU|Ensembl=ENSMMUG00000005198|UniProtKB=Q7JHP9	Transporter	TAS	92107910	PubMed	PTHR11616:SF38	SODIUM-DEPENDENT DOPAMINE TRANSPORTER
P00059	p53 pathway	P04623	CBP	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04393	Ras Pathway	P04570	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00220	c-Jun	XENTR|Xenbase=XB-GENE-482228|UniProtKB=F6RYL1	Uncharacterized protein	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	IGI	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P05917	Opioid proopiomelanocortin pathway	P06009	K+ channel	CHICK|Ensembl=ENSGALG00000016193|UniProtKB=E1BYI0	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P04398	p53 pathway feedback loops 2	P04651	Ras	MONDO|Gene=KRAS|UniProtKB=Q07983	GTPase KRas	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00629	PP2A	CANLF|Ensembl=ENSCAFG00000006453|UniProtKB=F6X958	Serine/threonine-protein phosphatase	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	BOVIN|Gene=CACNB1|UniProtKB=Q9MZL7	Voltage-dependent L-type calcium channel subunit beta-1	IC	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P06211	BMP/activin signaling pathway-drosophila	P06248	PDP	DROME|FlyBase=FBgn0029958|UniProtKB=Q9W3Q1	GM14286p	IDA	16510868	PubMed	PTHR13832:SF503	PYRUVATE DEHYDROGENASE  ACETYL-TRANSFERRING  -PHOSPHATASE 1, MITOCHONDRIAL
P06211	BMP/activin signaling pathway-drosophila	P06256	Full-length  BMP orthologous ligand	DROME|FlyBase=FBgn0000490|UniProtKB=P07713	Protein decapentaplegic	RCA	http://flybase.org/reports/FBgn0000490.html	Website	PTHR11848:SF234	PROTEIN DECAPENTAPLEGIC
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00047	PDGF signaling pathway	P01151	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01292	RSmads	BOVIN|Ensembl=ENSBTAG00000021772|UniProtKB=F1MD43	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF36	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	PANTR|Gene=CHRM2|UniProtKB=Q9N2A7	Muscarinic acetylcholine receptor M2 (Fragment)	ISS	8100450	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00005	Angiogenesis	P00221	JNK1	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	ISS	10851062	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	CHICK|Ensembl=ENSGALG00000013224|UniProtKB=F1NMA4	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00021	FGF signaling pathway	P00645	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	8649368	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00013	Cell cycle	P00480	Proteasome	TRYB2|Gene=Tb10.70.4510|UniProtKB=Q38BU2	Proteasome regulatory non-ATPase subunit 11	ISS	21975205	PubMed	PTHR10410:SF5	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 14
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ARATH|TAIR=AT3G46520|UniProtKB=P53497	Actin-12	ISS	14684598	PubMed	PTHR11937:SF276	ACTIN-12
P00047	PDGF signaling pathway	P01150	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04393	Ras Pathway	P04541	p90RSK	CANLF|Ensembl=ENSCAFG00000013171|UniProtKB=E2RP04	Uncharacterized protein	ISS	10480933	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00034	Integrin signalling pathway	P00925	MEK	MONDO|Ensembl=ENSMODG00000008266|UniProtKB=F6Z879	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00057	Wnt signaling pathway	P01438	PP2A	CAEBR|Gene=CBG23076|UniProtKB=A8Y4R8	Protein CBR-PPTR-2	ISS	10092233	PubMed	PTHR10257:SF3	PP2A-B', ISOFORM B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00859	NFkappaB	MACMU|Ensembl=ENSMMUG00000002990|UniProtKB=F7GVV0	Uncharacterized protein	ISS	9133421	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MOUSE|MGI=MGI=88313|UniProtKB=P25322	G1/S-specific cyclin-D1	ISS	93330551	PubMed	PTHR10177:SF67	G1/S-SPECIFIC CYCLIN-D1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Ensembl=ENSBTAG00000011461|UniProtKB=P28190	Adenosine receptor A1	ISS	12515326	PubMed	PTHR24246:SF1	ADENOSINE RECEPTOR A1
P00059	p53 pathway	P04609	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	11292874	PubMed	PTHR10048:SF14	PI-3 KINASE
P02763	Peptidoglycan biosynthesis	P03091	D-alanine-D-alanine ligase	RHOBA|EnsemblGenome=RB13271|UniProtKB=Q7UHD8	Probable D-alanine-D-alanine ligase	ISS			PTHR23132:SF0	D-ALANINE--D-ALANINE LIGASE FAMILY PROTEIN
P00005	Angiogenesis	P00256	PLC-gamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	CHICK|Ensembl=ENSGALG00000003267|UniProtKB=Q6DV79	Signal transducer and activator of transcription 3	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	ANOGA|EnsemblGenome=AGAP001478|UniProtKB=Q7PXM3	AGAP001478-PA	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	BRAFL|Gene=BRAFLDRAFT_220697|UniProtKB=C3ZSF0	Putative uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00005	Angiogenesis	P00192	PAR	RAT|RGD=69057|UniProtKB=Q9R1A7	Nuclear receptor subfamily 1 group I member 2	ISS			PTHR24082:SF39	NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2
P00019	Endothelin signaling pathway	P00586	Gq	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IGI	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	CHICK|Ensembl=ENSGALG00000003267|UniProtKB=Q6DV79	Signal transducer and activator of transcription 3	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04542	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	TRIVA|Gene=TVAG_034440|UniProtKB=A2EM81	Beta-tubulin, putative	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	MOUSE|MGI=MGI=88543|UniProtKB=Q60737	Casein kinase II subunit alpha	IDA	10806215	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00048	PI3 kinase pathway	P01199	Galpha	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05730	Endogenous cannabinoid signaling	P05746	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000006307|UniProtKB=H2SSM1	Uncharacterized protein	ISS			PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00024	Glycolysis	P00679	Aldolase	BOVIN|Ensembl=ENSBTAG00000012927|UniProtKB=A6QLL8	Fructose-bisphosphate aldolase	ISS	74094688	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g236559|UniProtKB=A7RRG4	Actin-related protein 2/3 complex subunit 4	ISS	9230079	PubMed	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00010	B cell activation	P00373	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00121	CD44 intracellular fragment	CHICK|Ensembl=ENSGALG00000007849|UniProtKB=F1NL98	Uncharacterized protein	IDA	14871815	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P02746	Heme biosynthesis	P02979	porphobilinogen synthase	METJA|EnsemblGenome=MJ_0643|UniProtKB=Q60178	Delta-aminolevulinic acid dehydratase	ISS			PTHR11458:SF0	DELTA-AMINOLEVULINIC ACID DEHYDRATASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	TAS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00560	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04569	Cdc42	ANOGA|EnsemblGenome=AGAP002440|UniProtKB=Q17031	Cdc42 homolog	ISS	12932731	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	TAS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P06664	Gonadotropin-releasing hormone receptor pathway	P06831	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	RCA	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00243	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05760	AC	MACMU|Ensembl=ENSMMUG00000010440|UniProtKB=F7CRV6	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00037	Ionotropic glutamate receptor pathway	P01020	NSF	NEUCR|EnsemblGenome=EFNCRG00000002604|UniProtKB=Q1K5G2	Vesicular-fusion protein SEC18	ISS	11348590	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00036	Interleukin signaling pathway	P00972	MNK1/2	RAT|RGD=1559603|UniProtKB=Q4G050	MAP kinase-interacting serine/threonine-protein kinase 1	ISS	9155018	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	NAS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00018	EGF receptor signaling pathway	P00552	Ras	RAT|RGD=3111|UniProtKB=P97538	Ras-related protein M-Ras	ISS			PTHR24070:SF268	RAS-RELATED PROTEIN M-RAS
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_94959|UniProtKB=C3XYC4	Putative uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00010	B cell activation	P00371	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02913	Thymidylate synthase	ECOLI|EcoGene=EG11002|UniProtKB=P0A884	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00005	Angiogenesis	P00226	Delta/Serrate	MOUSE|MGI=MGI=104659|UniProtKB=Q61483	Delta-like protein 1	ISS	12175503	PubMed	PTHR24044:SF380	DELTA-LIKE PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	CANLF|Ensembl=ENSCAFG00000000178|UniProtKB=J9P315	Uncharacterized protein	ISS	11907044	PubMed	PTHR44025:SF2	PROLOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	RAT|RGD=2746|UniProtKB=P31424	Metabotropic glutamate receptor 5	ISS	14614461	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00010	B cell activation	P00383	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P06959	CCKR signaling map	P07090	MAPK8-10	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	RCA	15153424	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00907	ERK	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS			PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	SCHPO|PomBase=SPBP19A11.03c|UniProtKB=P87048	26S proteasome regulatory subunit rpn1	ISS			PTHR10943:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2
P00019	Endothelin signaling pathway	P00591	PLCbeta	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00037	Ionotropic glutamate receptor pathway	P01020	NSF	CAEEL|WormBase=WBGene00003818|UniProtKB=Q94392	Vesicle-fusing ATPase	ISS	7969419	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P02786	Vitamin B6 biosynthesis	P03225	1-Deoxyxylulose-5-phosphate synthase	BACSU|EnsemblGenome=BSU24270|UniProtKB=P54523	1-deoxy-D-xylulose-5-phosphate synthase	ISS			PTHR43322:SF5	1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE 1-RELATED
P04398	p53 pathway feedback loops 2	P04661	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ANOGA|EnsemblGenome=AGAP000651|UniProtKB=P84185	Actin-5C	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00019	Endothelin signaling pathway	P00566	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00243	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	12411479	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000006307|UniProtKB=H2SSM1	Uncharacterized protein	IC			PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MACMU|Ensembl=ENSMMUG00000016675|UniProtKB=F6VTB5	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	YEAST|SGD=S000001550|UniProtKB=P36010	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00022	General transcription by RNA polymerase I	P00652	RNA Polymerase I  Complex	CANLF|Ensembl=ENSCAFG00000007174|UniProtKB=E2REX8	DNA-directed RNA polymerase subunit beta	ISS	15691654	PubMed	PTHR20856:SF5	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA2
P00060	Ubiquitin proteasome pathway	P01491	E2	BOVIN|Ensembl=ENSBTAG00000046276|UniProtKB=G3N222	Uncharacterized protein	ISS			PTHR24068:SF48	UBIQUITIN-CONJUGATING ENZYME E2 D3
P02781	Threonine biosynthesis	P03190	Threonine synthase	DEIRA|EnsemblGenome=DR_A0360|UniProtKB=Q9RYF8	Threonine synthase	ISS	10567266	PubMed	PTHR42690:SF1	THREONINE SYNTHASE-LIKE 2
P00049	Parkinson disease	P01219	SAPK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04393	Ras Pathway	P04559	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12960248	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	DANRE|ZFIN=ZDB-GENE-030131-7595|UniProtKB=Q6PBR4	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P06959	CCKR signaling map	P07198	CaMKIV	HUMAN|HGNC=1464|UniProtKB=Q16566	Calcium/calmodulin-dependent protein kinase type IV	RCA	10838169	PubMed	PTHR24349:SF152	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE IV
P00019	Endothelin signaling pathway	P00568	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	IGI	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00023	General transcription regulation	P00660	RNA Polymerase II	MACMU|Ensembl=ENSMMUG00000007524|UniProtKB=F6QCQ2	Uncharacterized protein	ISS	606023	OMIM	PTHR10917:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3
P00052	TGF-beta signaling pathway	P01286	TGFbeta	BOVIN|Ensembl=ENSBTAG00000002912|UniProtKB=P07995	Inhibin beta A chain	TAS	11451570	PubMed	PTHR11848:SF133	INHIBIN BETA A CHAIN
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00029	Huntington disease	P00807	Actin	PHYPA|Gene=PHYPADRAFT_225906|UniProtKB=A9TVP1	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	IC	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00012	Cadherin signaling pathway	P00477	GSK3beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00922	Collagen	CHICK|Gene=COL9A1|UniProtKB=P12106	Collagen alpha-1(IX) chain	IDA	10778855	PubMed	PTHR44652:SF3	COLLAGEN ALPHA-1 IX  CHAIN
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	MONDO|Ensembl=ENSMODG00000004410|UniProtKB=F6SV58	Uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF322	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01168	PI3K	XENTR|Xenbase=XB-GENE-6085226|UniProtKB=F6ZM84	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00019	Endothelin signaling pathway	P00575	furin	DROME|FlyBase=FBgn0004598|UniProtKB=P30432	Furin-like protease 2	ISS	10956649	PubMed	PTHR42884:SF2	FURIN-LIKE PROTEASE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHLRE|EnsemblGenome=CHLREDRAFT_24392|UniProtKB=A8JAV1	Actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	IDA	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04393	Ras Pathway	P04542	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9836512	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	BOVIN|Ensembl=ENSBTAG00000004242|UniProtKB=Q1JP79	Actin-related protein 2/3 complex subunit 1A	ISS	12963527	gi	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00052	TGF-beta signaling pathway	P01292	RSmads	RAT|RGD=3032|UniProtKB=P84025	Mothers against decapentaplegic homolog 3	ISS	9395284	PubMed	PTHR13703:SF25	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3
P00057	Wnt signaling pathway	P01444	Wnt	RAT|RGD=1305018|UniProtKB=D3ZF63	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00034	Integrin signalling pathway	P00944	Actin	MONBE|Gene=37852|UniProtKB=A9V489	Predicted protein	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P06664	Gonadotropin-releasing hormone receptor pathway	P06805	MKK3/6	MOUSE|MGI=MGI=1346868|UniProtKB=O09110	Dual specificity mitogen-activated protein kinase kinase 3	RCA	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CAEBR|Gene=CBG05858|UniProtKB=A8X1H0	Protein CBR-EGL-19 (Fragment)	ISS	11956331	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	ISS	3487386	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00006	Apoptosis signaling pathway	P00303	c-Jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00053	T cell activation	P01316	MHC-antigen	RAT|RGD=6502526|UniProtKB=Q95574	Major histocompatibility complex, class II, DM alpha	IPI	73139	PubMed	PTHR19944:SF50	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DM ALPHA CHAIN
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00021	FGF signaling pathway	P00624	14-3-3	XENTR|Xenbase=XB-GENE-1006026|UniProtKB=Q5XGC8	14-3-3 protein beta/alpha	ISS	10407019	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00012	Cadherin signaling pathway	P00474	Wnt	CHICK|Ensembl=ENSGALG00000005410|UniProtKB=Q9YGX6	Protein Wnt	IDA	8717036	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06214	GBB signaling pathway	P06294	GBB	DROME|FlyBase=FBgn0024234|UniProtKB=P27091	Protein 60A	IDA	10353905	PubMed	PTHR11848:SF54	PROTEIN 60A-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	TAKRU|Ensembl=ENSTRUG00000002223|UniProtKB=H2RY75	Uncharacterized protein (Fragment)	ISS	85270494	PubMed	PTHR18945:SF761	ALPHA8 SUBUNIT OF NICOTINIC ACETYLCHOLINE RECEPTOR
P00021	FGF signaling pathway	P00640	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	MACMU|Ensembl=ENSMMUG00000022884|UniProtKB=F7CAM5	Glutamine synthetase	ISS			PTHR20852:SF45	GLUTAMINE SYNTHETASE
P00019	Endothelin signaling pathway	P00574	Big ET1-4	RAT|RGD=2533|UniProtKB=P23943	Endothelin-2	IGI	8201007	PubMed	PTHR13874:SF9	ENDOTHELIN-2
P02749	Leucine biosynthesis	P02999	2-Isopropylmalate synthase	THEMA|EnsemblGenome=TM_0553|UniProtKB=Q9WZ23	2-isopropylmalate synthase	ISS			PTHR10277:SF9	2-ISOPROPYLMALATE SYNTHASE 1, CHLOROPLASTIC-RELATED
P00010	B cell activation	P00383	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	IDA	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	BOVIN|Gene=MYH2|UniProtKB=Q9BE41	Myosin-2	IC	10938134	PubMed	PTHR13140:SF385	MYOSIN-2
P00018	EGF receptor signaling pathway	P00561	STAT	PANTR|Ensembl=ENSPTRG00000009199|UniProtKB=H2QD19	Signal transducer and activator of transcription	ISS	95188889	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01311	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00036	Interleukin signaling pathway	P00973	PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00960	PTP	TAKRU|Ensembl=ENSTRUG00000018529|UniProtKB=H2VDZ2	Tyrosine-protein phosphatase non-receptor type	ISS	1382983	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00556	PLCgamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IGI	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00005	Angiogenesis	P00238	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	USTMA|Gene=UMAG_04456|UniProtKB=A0A0D1DSN6	Chromosome 14, whole genome shotgun sequence	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	TAKRU|Ensembl=ENSTRUG00000016081|UniProtKB=H2UVZ1	Uncharacterized protein	ISS	12888804	PubMed	PTHR43940:SF3	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT BETA
P00029	Huntington disease	P00774	Dynein complex	CAEBR|Gene=CBG19682|UniProtKB=A8XW67	Protein CBR-DLC-1	ISS	9454836	PubMed	PTHR11886:SF35	DYNEIN LIGHT CHAIN 2, CYTOPLASMIC
P00006	Apoptosis signaling pathway	P00302	ATF	MOUSE|MGI=MGI=109349|UniProtKB=P16951	Cyclic AMP-dependent transcription factor ATF-2	ISS	7875593	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P05915	Opioid proenkephalin pathway	P05991	Enkephalin	XENTR|Xenbase=XB-GENE-942760|UniProtKB=F6Y5F6	Uncharacterized protein	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00006	Apoptosis signaling pathway	P00269	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	DROME|FlyBase=FBgn0030011|UniProtKB=Q9W3J1	Gbeta5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00011	Blood coagulation	P00416	Prothrombin	PANTR|Ensembl=ENSPTRG00000003552|UniProtKB=H2Q3I2	Prothrombin	ISS	4503635	gi	PTHR24254:SF10	PROTHROMBIN
P05730	Endogenous cannabinoid signaling	P05748	mGluR	CHICK|Ensembl=ENSGALG00000017238|UniProtKB=F1NWG3	Uncharacterized protein	ISS	14614461	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00019	Endothelin signaling pathway	P00591	PLCbeta	CAEEL|WormBase=WBGene00004037|UniProtKB=Q9XWB7	Phosphoinositide phospholipase C	ISS			PTHR10336:SF9	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00034	Integrin signalling pathway	P00919	Arf6	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g166872|UniProtKB=A7S615	Predicted protein	ISS	11752622	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	TAS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	BOVIN|Ensembl=ENSBTAG00000011339|UniProtKB=A7MAZ4	Transcription initiation factor TFIID subunit 8	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00059	p53 pathway	G01566	TSP1	CANLF|Ensembl=ENSCAFG00000008704|UniProtKB=F1PBI6	Uncharacterized protein	ISS	7521539	PubMed	PTHR10199:SF78	THROMBOSPONDIN-1
P00021	FGF signaling pathway	P00623	FGF	MONDO|Ensembl=ENSMODG00000006934|UniProtKB=F6PQX0	Fibroblast growth factor	ISS			PTHR11486:SF67	FIBROBLAST GROWTH FACTOR 11
P04393	Ras Pathway	P04567	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	TAKRU|Ensembl=ENSTRUG00000011297|UniProtKB=H2TV18	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00048	PI3 kinase pathway	P01177	P110ACT	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g171933|UniProtKB=A7SLP4	Predicted protein	ISS			PTHR23431:SF3	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00631	Grb2	MACMU|Ensembl=ENSMMUG00000005327|UniProtKB=F7GJG7	GRB2-related adapter protein	ISS	8647802	PubMed	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P00052	TGF-beta signaling pathway	P01275	P38	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00036	Interleukin signaling pathway	P00977	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IDA	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00623	FGF	CANLF|Ensembl=ENSCAFG00000006845|UniProtKB=E2RN01	Fibroblast growth factor	ISS	11306498	PubMed	PTHR11486:SF72	FIBROBLAST GROWTH FACTOR 20
P00029	Huntington disease	P00799	JNK-2	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MACMU|Ensembl=ENSMMUG00000012054|UniProtKB=F6TII3	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00013	Cell cycle	P00480	Proteasome	BOVIN|Gene=PSMD13|UniProtKB=Q5E964	26S proteasome non-ATPase regulatory subunit 13	ISS	99239941	PubMed	PTHR10539:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MONDO|Ensembl=ENSMODG00000023470|UniProtKB=F6T6U1	Uncharacterized protein	ISS	11701344	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P02749	Leucine biosynthesis	P02999	2-Isopropylmalate synthase	YEAST|SGD=S000005634|UniProtKB=Q12166	2-isopropylmalate synthase 2, mitochondrial	ISS			PTHR10277:SF31	2-ISOPROPYLMALATE SYNTHASE-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00212	EphR	RAT|RGD=1305602|UniProtKB=D3ZH39	Eph receptor B3 (Predicted)	ISS	9990854	PubMed	PTHR24416:SF506	EPHRIN TYPE-B RECEPTOR 3
P00029	Huntington disease	P00790	beta-Tubulin	MACMU|Ensembl=ENSMMUG00000011029|UniProtKB=F7DCY3	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	ORNAN|Ensembl=ENSOANG00000002061|UniProtKB=F7ANC6	Uncharacterized protein	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P02788	Xanthine and guanine salvage pathway	P03248	Deoxyguanosine phosphorylase	MYCTU|EnsemblGenome=Rv3307|UniProtKB=P9WP01	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	HUMAN|HGNC=4584|UniProtKB=Q05586	Glutamate receptor ionotropic, NMDA 1	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CHICK|Gene=ACTG2|UniProtKB=P63270	Actin, gamma-enteric smooth muscle	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02749	Leucine biosynthesis	P03001	3-Isopropylmalate dehydrogenase	METAC|EnsemblGenome=MA_0201|UniProtKB=Q8TU72	3-isopropylmalate dehydrogenase	ISS			PTHR43275:SF1	D-MALATE DEHYDROGENASE  DECARBOXYLATING
P00025	Hedgehog signaling pathway	P00682	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	8838325	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00012	Cadherin signaling pathway	P00470	F-actin	CHICK|Ensembl=ENSGALG00000011086|UniProtKB=P68139	Actin, alpha skeletal muscle	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P02775	Salvage pyrimidine ribonucleotides	P03151	Uracil phosphoribosyl  transferase	ARATH|TAIR=AT1G55810|UniProtKB=Q8VYB2	Uridine kinase-like protein 3	ISS			PTHR10285:SF97	URIDINE KINASE-LIKE PROTEIN 3-RELATED
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00049	Parkinson disease	P01238	14-3-3	MACMU|Ensembl=ENSMMUG00000009945|UniProtKB=F6RIX6	14-3-3 protein eta	ISS	10407019	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04451	CRHR1	MACMU|Ensembl=ENSMMUG00000011758|UniProtKB=F7HSL1	Uncharacterized protein	ISS	11145609	PubMed	PTHR12011:SF274	CORTICOTROPIN-RELEASING FACTOR RECEPTOR 2
P00034	Integrin signalling pathway	P00944	Actin	MONDO|Ensembl=ENSMODG00000000365|UniProtKB=F6R9F4	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00810	GAPDH	MOUSE|MGI=MGI=95640|UniProtKB=P16858	Glyceraldehyde-3-phosphate dehydrogenase	IPI	8612237	PubMed	PTHR10836:SF51	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	XENTR|Xenbase=XB-GENE-5749635|UniProtKB=Q28FB2	Aldehyde dehydrogenase	ISS	14724059	PubMed	PTHR43570:SF7	SUBFAMILY NOT NAMED
P00010	B cell activation	P00391	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00552	Ras	MONDO|Ensembl=ENSMODG00000025248|UniProtKB=F7F5X1	Uncharacterized protein	ISS	99084794	PubMed	PTHR24070:SF186	GTPASE KRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	DICDI|dictyBase=DDB_G0277143|UniProtKB=P36408	Guanine nucleotide-binding protein subunit beta	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00029	Huntington disease	P00786	ARF	MOUSE|MGI=MGI=2445172|UniProtKB=P61208	ADP-ribosylation factor-like protein 4C	ISS	12932731	PubMed	PTHR11711:SF119	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 4C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00848	Grb	MOUSE|MGI=MGI=1333842|UniProtKB=O89100	GRB2-related adaptor protein 2	IDA	11971956	PubMed	PTHR24418:SF299	GRB2-RELATED ADAPTER PROTEIN 2
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	DANRE|ZFIN=ZDB-GENE-050706-89|UniProtKB=F1RDG9	Tyrosine-protein kinase fynb	ISS	11078745	PubMed	PTHR24418:SF242	TYROSINE-PROTEIN KINASE FYNB
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00034	Integrin signalling pathway	P00936	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	IC	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00005	Angiogenesis	P00182	p38MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MACMU|Ensembl=ENSMMUG00000032572|UniProtKB=F7D7Y7	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00054	Toll receptor signaling pathway	P01375	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00012	Cadherin signaling pathway	P00474	Wnt	PANTR|Ensembl=ENSPTRG00000004892|UniProtKB=H2Q5U3	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	TAS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P06959	CCKR signaling map	P07091	PAK	HUMAN|HGNC=8590|UniProtKB=Q13153	Serine/threonine-protein kinase PAK 1	RCA	11376654	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00053	T cell activation	P01306	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P04398	p53 pathway feedback loops 2	P04651	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00021	FGF signaling pathway	P00636	FGFR1-4	CANLF|Ensembl=ENSCAFG00000014993|UniProtKB=F1P9Z7	Fibroblast growth factor receptor	ISS	12441294	PubMed	PTHR24416:SF505	FIBROBLAST GROWTH FACTOR RECEPTOR 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04393	Ras Pathway	P04570	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00034	Integrin signalling pathway	P00938	Cdc42	TAKRU|Ensembl=ENSTRUG00000008289|UniProtKB=H2T7U8	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF129	CDC42L PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00012	Cadherin signaling pathway	P00471	Cadherin	CANLF|Ensembl=ENSCAFG00000004944|UniProtKB=F1P7Y5	Uncharacterized protein	ISS	8120095	PubMed	PTHR43912:SF5	PROTOCADHERIN-9
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00924	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00019	Endothelin signaling pathway	P00586	Gq	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00589	Akt	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	IGI	7876156	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	MACMU|Ensembl=ENSMMUG00000016675|UniProtKB=F6VTB5	Uncharacterized protein	ISS	11554549	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05731	GABA-B receptor II signaling	P05754	Ggamma	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	RCA	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IDA	14526383	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	RAT|RGD=2157|UniProtKB=P29067	Beta-arrestin-2	IDA	9388255	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00029	Huntington disease	P00774	Dynein complex	SCHMA|EnsemblGenome=Smp_019310|UniProtKB=G4LUC6	Cytoplasmic dynein light chain, putative	ISS	9454836	PubMed	PTHR11886:SF62	DYNEIN, LIGHT CHAIN, LC8-TYPE 2
P00047	PDGF signaling pathway	P01157	MAPKAPK2	MACMU|Ensembl=ENSMMUG00000023567|UniProtKB=F7HHY8	Uncharacterized protein	ISS	7923354	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00057	Wnt signaling pathway	P01465	Ggamma	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	RCA	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00045	Notch signaling pathway	P01114	Ntm	MACMU|Ensembl=ENSMMUG00000013637|UniProtKB=F7GL52	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P05916	Opioid prodynorphin pathway	P06002	G-protein	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00036	Interleukin signaling pathway	P00983	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00049	Parkinson disease	P01238	14-3-3	DANRE|ZFIN=ZDB-GENE-011115-1|UniProtKB=Q6PC29	14-3-3 protein gamma-1	ISS	1317796	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00053	T cell activation	P01323	I kappa B	MACMU|Ensembl=ENSMMUG00000020374|UniProtKB=F6UMS2	NF-kappa-B inhibitor alpha	ISS	14665694	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00025	Hedgehog signaling pathway	P00693	Ubiquitin ligase	HUMAN|HGNC=16806|UniProtKB=O95071	E3 ubiquitin-protein ligase UBR5	ISS			PTHR11254:SF402	E3 UBIQUITIN-PROTEIN LIGASE UBR5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MACMU|Ensembl=ENSMMUG00000014762|UniProtKB=F7G0R4	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF344	MYOSIN-7
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000014334|UniProtKB=F7CYY6	Uncharacterized protein	ISS	11861492	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P06959	CCKR signaling map	G06994	MMP9	HUMAN|HGNC=7176|UniProtKB=P14780	Matrix metalloproteinase-9	RCA	11971760	PubMed	PTHR10201:SF30	MATRIX METALLOPROTEINASE-9
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00819	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00021	FGF signaling pathway	P00640	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IGI	7565716	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00006	Apoptosis signaling pathway	P00310	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	ARATH|TAIR=AT1G07880|UniProtKB=Q9LQQ9	Mitogen-activated protein kinase 13	TAS			PTHR24055:SF185	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00019	Endothelin signaling pathway	P00568	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	3755548	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00053	T cell activation	P01307	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00018	EGF receptor signaling pathway	P00561	STAT	CHICK|Ensembl=ENSGALG00000003267|UniProtKB=Q6DV79	Signal transducer and activator of transcription 3	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	PANTR|Ensembl=ENSPTRG00000003795|UniProtKB=H2Q3X5	Muscarinic acetylcholine receptor	ISS	12181435	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00029	Huntington disease	P00796	Kainate receptor	PANTR|Ensembl=ENSPTRG00000013825|UniProtKB=H2RAK4	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02728	Arginine biosynthesis	P02847	N-actetylornithine deacetylase	RHOBA|EnsemblGenome=RB12133|UniProtKB=Q7UJ49	ArgE/DapE/Acy1 family protein	ISS			PTHR43270:SF4	RE11562P
P02738	De novo purine biosynthesis	P02908	Phosphoribosylamine glycine ligase	METAC|EnsemblGenome=MA_3309|UniProtKB=Q8TKT6	Phosphoribosylamine--glycine ligase	ISS			PTHR43472:SF1	PHOSPHORIBOSYLAMINE--GLYCINE LIGASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=69424|UniProtKB=Q99P84	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	15611108	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04398	p53 pathway feedback loops 2	P04660	SIAH-1	MOUSE|MGI=MGI=108063|UniProtKB=Q06985	E3 ubiquitin-protein ligase SIAH1B	ISS	14985507	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MACMU|Ensembl=ENSMMUG00000010347|UniProtKB=F6R9A9	Bone morphogenetic protein 3	ISS	9759503	PubMed	PTHR11848:SF144	BONE MORPHOGENETIC PROTEIN 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00054	Toll receptor signaling pathway	P01358	ERK1	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00983	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01332	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01175	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	8264585	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00012	Cadherin signaling pathway	P00475	Frizzled	ANOGA|Gene=AgaP_AGAP008871|UniProtKB=Q7PWS3	AGAP008871-PA (Fragment)	ISS	8717036	PubMed	PTHR11309:SF23	FRIZZLED-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	TAS	9716402	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00048	PI3 kinase pathway	P01179	PKB	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00321	HSP70	YEAST|SGD=S000000905|UniProtKB=P22202	Heat shock protein SSA4	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	HUMAN|HGNC=5465|UniProtKB=P08069	Insulin-like growth factor 1 receptor	TAS	6754360	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	PSEAE|EnsemblGenome=PA0219|UniProtKB=Q9I6R9	Probable aldehyde dehydrogenase	IC			PTHR11699:SF211	ALDEHYDE DEHYDROGENASE 5, MITOCHONDRIAL
P00056	VEGF signaling pathway	P01413	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	ISS	12660731	PubMed	PTHR10048:SF14	PI-3 KINASE
P00034	Integrin signalling pathway	P00944	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g169611|UniProtKB=A7SEB1	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	PANTR|Ensembl=ENSPTRG00000020039|UniProtKB=H2R9W1	Uncharacterized protein	ISS	11443533	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BOVIN|Ensembl=ENSBTAG00000015364|UniProtKB=E1BEN9	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00056	VEGF signaling pathway	P01423	p38MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00013	Cell cycle	P00484	Cyclin D	MOUSE|MGI=MGI=88313|UniProtKB=P25322	G1/S-specific cyclin-D1	ISS	93330551	PubMed	PTHR10177:SF67	G1/S-SPECIFIC CYCLIN-D1
P00057	Wnt signaling pathway	P01438	PP2A	RAT|RGD=1305657|UniProtKB=A0A0G2JTA1	Protein Ppp2r5e	ISS	11007767	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00021	FGF signaling pathway	P00642	MEK1-2	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MACMU|Ensembl=ENSMMUG00000021442|UniProtKB=F7EAQ8	Muscarinic acetylcholine receptor	ISS	12181435	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00048	PI3 kinase pathway	P01190	PDK1 ACT	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	IGI	15531926	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00047	PDGF signaling pathway	P01161	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01443	Phospholipase C	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00018	EGF receptor signaling pathway	P00545	JNK1-3	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04552	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	IDA	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MONDO|Ensembl=ENSMODG00000012546|UniProtKB=F6PM16	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00004	Alzheimer disease-presenilin pathway	P00126	Fe65	RAT|RGD=620853|UniProtKB=O35827	Amyloid beta A4 precursor protein-binding family B member 3	IDA			PTHR14058:SF10	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 3
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	PANTR|Ensembl=ENSPTRG00000012660|UniProtKB=H2QJ07	Activating transcription factor 2	ISS	10207617	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00059	p53 pathway	P04630	PP2A	RAT|RGD=3380|UniProtKB=P63331	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=109211|UniProtKB=Q8BWW9	Serine/threonine-protein kinase N2	ISS	125549	gi	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-478663|UniProtKB=F7EG64	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	MACMU|Ensembl=ENSMMUG00000012422|UniProtKB=F7DJH4	Tyrosine-protein kinase receptor	ISS	10226785	PubMed	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-010705-1|UniProtKB=Q90Z40	Guanine nucleotide-binding protein subunit gamma	IC	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	IDA	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	CANLF|Ensembl=ENSCAFG00000013755|UniProtKB=Q49LX5	Somatostatin receptor type 1	ISS			PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P00034	Integrin signalling pathway	P00925	MEK	MACMU|Ensembl=ENSMMUG00000010904|UniProtKB=F7GLY5	Uncharacterized protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04393	Ras Pathway	P04546	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P06959	CCKR signaling map	G07272	MYC	HUMAN|HGNC=7553|UniProtKB=P01106	Myc proto-oncogene protein	RCA	17167838	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00004	Alzheimer disease-presenilin pathway	P00117	E-cadherin C-terminal fragment	MACMU|Ensembl=ENSMMUG00000010393|UniProtKB=F7D992	Uncharacterized protein	ISS	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P00034	Integrin signalling pathway	P00924	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00195	APC	MOUSE|MGI=MGI=1346052|UniProtKB=Q9Z1K7	Adenomatous polyposis coli protein 2	ISS	10491393	PubMed	PTHR12607:SF3	ADENOMATOUS POLYPOSIS COLI PROTEIN 2
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00010	B cell activation	P00383	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00047	PDGF signaling pathway	P01154	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P02788	Xanthine and guanine salvage pathway	P03248	Deoxyguanosine phosphorylase	MOUSE|MGI=MGI=97365|UniProtKB=P23492	Purine nucleoside phosphorylase	ISS	7903568	PubMed	PTHR11904:SF12	PURINE NUCLEOSIDE PHOSPHORYLASE
P02775	Salvage pyrimidine ribonucleotides	P03149	Cytidine kinase	DROME|FlyBase=FBgn0263398|UniProtKB=Q9VC99	Probable uridine-cytidine kinase	ISS			PTHR10285:SF70	URIDINE-CYTIDINE KINASE 2
P04384	Gamma-aminobutyric acid synthesis	P04480	GABA aminotransferase	PANTR|Ensembl=ENSPTRG00000007746|UniProtKB=H2QAJ4	4-aminobutyrate aminotransferase	ISS	10989446	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	BOVIN|Ensembl=ENSBTAG00000002349|UniProtKB=P61267	Syntaxin-1B	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00048	PI3 kinase pathway	P01187	IR	MOUSE|MGI=MGI=96575|UniProtKB=P15208	Insulin receptor	IDA	2983222	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IPI	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00020	FAS signaling pathway	P00615	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01450	Bcl9	MACMU|Ensembl=ENSMMUG00000016786|UniProtKB=F7D4Z2	B-cell CLL/lymphoma 9 protein	ISS	11955446	PubMed	PTHR15185:SF5	B-CELL CLL/LYMPHOMA 9 PROTEIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9406|UniProtKB=Q16513	Serine/threonine-protein kinase N2	IC	125549	gi	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P05915	Opioid proenkephalin pathway	P05994	G-protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00049	Parkinson disease	P01242	Casein kinase I	ORYSJ|EnsemblGenome=OS01G0570500|UniProtKB=Q656Y0	Os01g0570500 protein	IDA	10617630	PubMed	PTHR11909:SF162	SUBFAMILY NOT NAMED
P00045	Notch signaling pathway	P01107	Fringe	DROME|FlyBase=FBgn0011591|UniProtKB=Q24342	Fringe glycosyltransferase	IDA	12909620	PubMed	PTHR10811:SF5	FRINGE GLYCOSYLTRANSFERASE
P00010	B cell activation	P00376	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	DROME|FlyBase=FBgn0036790|UniProtKB=Q9VVQ1	Allatostatin C receptor 1	IDA	12562507	PubMed	PTHR24229:SF51	ALLATOSTATIN C RECEPTOR 1-RELATED
P00048	PI3 kinase pathway	P01189	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	BOVIN|Ensembl=ENSBTAG00000002125|UniProtKB=F1N461	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00029	Huntington disease	P00775	Rac	DANRE|ZFIN=ZDB-GENE-030131-5721|UniProtKB=Q7ZVI3	Ras homolog gene family, member Q	ISS	12932731	PubMed	PTHR24072:SF13	RHO-RELATED GTP-BINDING PROTEIN RHOQ
P00012	Cadherin signaling pathway	P00470	F-actin	CHICK|Ensembl=ENSGALG00000028749|UniProtKB=Q5ZMQ2	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00018	EGF receptor signaling pathway	P00551	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01236	Casein kinase II	XENTR|Xenbase=XB-GENE-487924|UniProtKB=F6WVD0	Casein kinase II subunit beta (Fragment)	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	GIAIC|EnsemblGenome=GL50803_3869|UniProtKB=E2RU39	Syntaxin 16	IC			PTHR19957:SF83	SYNTAXIN-16
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00570	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	188830	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00049	Parkinson disease	P01227	20S proteasome	CANLF|Ensembl=ENSCAFG00000020224|UniProtKB=E2RPC6	Proteasome subunit beta type	ISS	12859888	PubMed	PTHR11599:SF42	PROTEASOME SUBUNIT BETA TYPE-7
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00470	F-actin	XENTR|Xenbase=XB-GENE-491618|UniProtKB=Q6P378	Actin, cytoplasmic 2	ISS	3487386	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BOVIN|Ensembl=ENSBTAG00000014614|UniProtKB=P62739	Actin, aortic smooth muscle	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P04393	Ras Pathway	P04578	Rho	XENTR|Xenbase=XB-GENE-478301|UniProtKB=Q6NVL3	Ras homolog gene family, member B	ISS	13679859	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00045	Notch signaling pathway	P01101	Su(H)	DANRE|ZFIN=ZDB-GENE-031117-1|UniProtKB=A4FTT3	Rbpja protein	ISS	12145413	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05731	GABA-B receptor II signaling	P05754	Ggamma	MOUSE|MGI=MGI=1913316|UniProtKB=P61953	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	ISS	2122451	PubMed	PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00046	Oxidative stress response	P01127	eEF2K	CANLF|Ensembl=ENSCAFG00000017716|UniProtKB=E2RIJ6	Uncharacterized protein	ISS	11500363	PubMed	PTHR14187:SF56	EUKARYOTIC ELONGATION FACTOR 2 KINASE
P00019	Endothelin signaling pathway	P00591	PLCbeta	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00057	Wnt signaling pathway	P01443	Phospholipase C	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00010	B cell activation	P00397	IKK	RAT|RGD=621375|UniProtKB=Q9QY78	Inhibitor of nuclear factor kappa-B kinase subunit beta	IGI	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00029	Huntington disease	P00807	Actin	TRYB2|Gene=Tb09.211.0620|UniProtKB=Q38E94	Actin A	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00038	JAK/STAT signaling pathway	P01027	STAT	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	15825084	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IGI	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04393	Ras Pathway	P04570	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	8838325	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00049	Parkinson disease	P01211	ERK	ORYSJ|EnsemblGenome=OS02G0148100|UniProtKB=Q6Z437	Mitogen-activated protein kinase 3	IDA	11707292	PubMed	PTHR24055:SF216	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	ISS	11035810	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00047	PDGF signaling pathway	P01160	IP3 receptor	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00012	Cadherin signaling pathway	P00474	Wnt	RAT|RGD=1311441|UniProtKB=A0A0G2K3B7	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	PANTR|Ensembl=ENSPTRG00000033819|UniProtKB=H2QV00	Actin related protein 2/3 complex, subunit 1A, 41kDa	ISS	12963527	gi	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	IC	15621031	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P04395	Vasopressin synthesis	P04597	Signal Peptide	TAKRU|Ensembl=ENSTRUG00000015631|UniProtKB=H2USP0	Uncharacterized protein	ISS	1706187	PubMed	PTHR11681:SF14	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04574	PLD	HUMAN|HGNC=9067|UniProtKB=Q13393	Phospholipase D1	IDA	15668389	PubMed	PTHR18896:SF57	PHOSPHOLIPASE D1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95818|UniProtKB=Q61626	Glutamate receptor ionotropic, kainate 5	ISS	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	DICPU|Gene=DICPUDRAFT_92731|UniProtKB=F0ZWE6	Putative uncharacterized protein rasG	ISS	89128893	PubMed	PTHR24070:SF282	RAS GTPASE-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00050	Plasminogen activating cascade	P01245	PAI-1	RAT|RGD=3249|UniProtKB=P20961	Plasminogen activator inhibitor 1	ISS	10692390	PubMed	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	HUMAN|HGNC=145|UniProtKB=P63267	Actin, gamma-enteric smooth muscle	IC	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04546	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IDA	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02783	Tryptophan biosynthesis	P03206	Anthranilate synthase	AQUAE|EnsemblGenome=aq_582|UniProtKB=O66849	Anthranilate synthase component 1	ISS			PTHR11236:SF9	ANTHRANILATE SYNTHASE COMPONENT 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	PANTR|Ensembl=ENSPTRG00000016003|UniProtKB=H2QPD3	Uncharacterized protein	ISS			PTHR18945:SF489	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-9
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IDA	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P02738	De novo purine biosynthesis	P02892	5-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase	PLAF7|EnsemblGenome=PFB0295w|UniProtKB=Q7KWJ4	Adenylosuccinate lyase	ISS			PTHR43411:SF1	ADENYLOSUCCINATE LYASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	DANRE|ZFIN=ZDB-GENE-040718-276|UniProtKB=F1Q9W6	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF26	REGULATOR OF G-PROTEIN SIGNALING 7
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00981	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000008536|UniProtKB=F6WBZ5	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00012	Cadherin signaling pathway	P00474	Wnt	DANRE|ZFIN=ZDB-GENE-990415-278|UniProtKB=P43446	Protein Wnt-10a	IDA	11266476	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00030	Hypoxia response via HIF activation	P00823	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01142	p90RSK	MONDO|Ensembl=ENSMODG00000014313|UniProtKB=F7BTW0	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00030	Hypoxia response via HIF activation	P00819	AKT	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00058	mRNA splicing	P01478	U2	ORNAN|Ensembl=ENSOANG00000001237|UniProtKB=F6YE01	Uncharacterized protein	ISS			PTHR10501:SF21	U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B''
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04393	Ras Pathway	P04556	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00547	PP2A	BOVIN|Ensembl=ENSBTAG00000019784|UniProtKB=A4FV68	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	ISS	10092233	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	IC	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	12885769	PubMed	PTHR10202:SF13	PRESENILIN-2
P00018	EGF receptor signaling pathway	P00548	RKIP	DROME|FlyBase=FBgn0037433|UniProtKB=Q9VI09	GH14494p	ISS			PTHR11362:SF75	GH14494P
P00034	Integrin signalling pathway	P00907	ERK	MONDO|Ensembl=ENSMODG00000004896|UniProtKB=F7C2C6	Uncharacterized protein (Fragment)	ISS	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00010	B cell activation	P00390	Blk	RAT|RGD=1308859|UniProtKB=Q4KM97	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF181	TYROSINE-PROTEIN KINASE BLK
P00049	Parkinson disease	P01211	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	IDA	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00023	General transcription regulation	P00664	TFIIH complex	BOVIN|Ensembl=ENSBTAG00000046757|UniProtKB=A6H7G8	GTF2H4 protein	ISS			PTHR13152:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000005922|UniProtKB=H2R0P7	Protocadherin 9	ISS	8120095	PubMed	PTHR43912:SF5	PROTOCADHERIN-9
P02741	Flavin biosynthesis	P02936	FAD synthetase	BACSU|EnsemblGenome=BSU29300|UniProtKB=P94465	RNA-binding riboflavin kinase RibR	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P00035	Interferon-gamma signaling pathway	P00960	PTP	MACMU|Ensembl=ENSMMUG00000013253|UniProtKB=F6ZJD8	Tyrosine-protein phosphatase non-receptor type	ISS	7681589	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	RAT|RGD=619751|UniProtKB=O88302	Guanine nucleotide-binding protein subunit alpha-15	ISS	10629036	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P02759	Pyridoxal-5-phosphate biosynthesis	P03061	Pyridoxine-5-phosphate oxidase	DEIRA|EnsemblGenome=DR_0495|UniProtKB=Q9RX20	Pyridoxine/pyridoxamine 5'-phosphate oxidase	ISS	10567266	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00017	DNA replication	P00527	Histones	MACMU|Ensembl=ENSMMUG00000030873|UniProtKB=F6Y435	Histone H3	ISS	12413958	PubMed	PTHR11426:SF170	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00274	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00101	BACE-1	PANTR|Ensembl=ENSPTRG00000013924|UniProtKB=H2R1L7	Beta-site APP-cleaving enzyme 2	ISS			PTHR13683:SF262	BETA-SECRETASE 2
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00058	mRNA splicing	P01476	U4	MACMU|Ensembl=ENSMMUG00000016301|UniProtKB=F7GUG7	Uncharacterized protein	ISS	9328476	PubMed	PTHR14212:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P06664	Gonadotropin-releasing hormone receptor pathway	P06755	CBP	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	RCA	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	CHICK|Ensembl=ENSGALG00000001334|UniProtKB=F1NLV4	Uncharacterized protein	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	TAKRU|Ensembl=ENSTRUG00000009557|UniProtKB=A0JGX5	Insulin-like growth factor II	ISS	4504609	gi	PTHR11454:SF10	INSULIN-LIKE GROWTH FACTOR II
P04393	Ras Pathway	P04557	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00006	Apoptosis signaling pathway	P00301	Apaf-1	MACMU|Ensembl=ENSMMUG00000022404|UniProtKB=F6U0K7	Apoptotic protease-activating factor 1	ISS	10364241	PubMed	PTHR22845:SF5	APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
P00059	p53 pathway	P04633	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00019	Endothelin signaling pathway	P00586	Gq	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	YEAST|SGD=S000000028|UniProtKB=P31109	Synaptobrevin homolog 1	ISS			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00056	VEGF signaling pathway	P01409	cPLA2	RAT|RGD=67366|UniProtKB=P50393	Cytosolic phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	NEUCR|EnsemblGenome=EFNCRG00000004240|UniProtKB=Q01386	cAMP-dependent protein kinase regulatory subunit	ISS	2372396	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	RCA			PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	XENTR|Xenbase=XB-GENE-1016046|UniProtKB=Q28C85	Pyrroline-5-carboxylate reductase	ISS			PTHR11645:SF46	PYRROLINE-5-CARBOXYLATE REDUCTASE
P00057	Wnt signaling pathway	P01435	SWI/SNF	BOVIN|Ensembl=ENSBTAG00000005979|UniProtKB=E1BCV0	Uncharacterized protein	ISS	11532957	PubMed	PTHR10799:SF812	LYMPHOID-SPECIFIC HELICASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=69424|UniProtKB=Q99P84	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	7822322	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00036	Interleukin signaling pathway	P00968	Ikk	BOVIN|Ensembl=ENSBTAG00000007599|UniProtKB=Q95KV0	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	HUMAN|HGNC=4583|UniProtKB=Q16478	Glutamate receptor ionotropic, kainate 5	ISS	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	YEAST|SGD=S000001550|UniProtKB=P36010	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05918	p38 MAPK pathway	P06023	MEF	MONDO|Ensembl=ENSMODG00000020223|UniProtKB=F7FXI4	Uncharacterized protein	ISS	11274345	PubMed	PTHR11945:SF25	MYOCYTE-SPECIFIC ENHANCER FACTOR 2C
P00029	Huntington disease	P00774	Dynein complex	CIOIN|Ensembl=ENSCING00000023149|UniProtKB=Q2PEE1	Dynein light chain 6	ISS	9454836	PubMed	PTHR11886:SF62	DYNEIN, LIGHT CHAIN, LC8-TYPE 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00053	T cell activation	P01316	MHC-antigen	MACMU|Ensembl=ENSMMUG00000019371|UniProtKB=A2TJ58	MHC class II antigen	ISS	73139	PubMed	PTHR19944:SF64	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DP ALPHA 1 CHAIN
P00019	Endothelin signaling pathway	P00577	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01192	p110	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00269	MAPK	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	ISS	19114921	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00053	T cell activation	P01331	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00030	Hypoxia response via HIF activation	P00824	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	SCHPO|PomBase=SPAC6G9.11|UniProtKB=Q92356	Synaptobrevin homolog 1	IC			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MACMU|Ensembl=ENSMMUG00000010392|UniProtKB=F7ASR8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P02738	De novo purine biosynthesis	P02889	dGDP kinase	RAT|RGD=619879|UniProtKB=G3V816	Nucleoside diphosphate kinase	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000008536|UniProtKB=F6WBZ5	Mitogen-activated protein kinase	ISS	12912994	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00057	Wnt signaling pathway	P01428	Frizzled	RAT|RGD=2321905|UniProtKB=D4ACM8	Protein Fzd7	ISS	8717036	PubMed	PTHR11309:SF31	FRIZZLED-7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	PANTR|Ensembl=ENSPTRG00000008152|UniProtKB=H2QB67	C-C motif chemokine	ISS	16903084	gi	PTHR12015:SF102	C-C MOTIF CHEMOKINE 22
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00010	B cell activation	P00369	MEKK	MOUSE|MGI=MGI=1346874|UniProtKB=Q61084	Mitogen-activated protein kinase kinase kinase 3	IDA	11730323	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00010	B cell activation	P00386	Calcineurin	CHICK|Ensembl=ENSGALG00000005243|UniProtKB=E1C2T7	Serine/threonine-protein phosphatase	ISS	12091710	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	RAT|RGD=70958|UniProtKB=P19492	Glutamate receptor 3	IC	12941441	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00034	Integrin signalling pathway	P00927	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	15470041	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01094	gamma	PANTR|Ensembl=ENSPTRG00000022726|UniProtKB=H2R3V0	Cholinergic receptor, nicotinic, gamma	ISS	95224005	PubMed	PTHR18945:SF60	ACETYLCHOLINE RECEPTOR SUBUNIT GAMMA
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04417	5HT transporter	CANLF|Ensembl=ENSCAFG00000018990|UniProtKB=F1PXA1	Transporter	ISS	14653308	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P04393	Ras Pathway	P04542	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	HUMAN|HGNC=144|UniProtKB=P63261	Actin, cytoplasmic 2	IC	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00037	Ionotropic glutamate receptor pathway	P01018	Glu1	CHICK|Ensembl=ENSGALG00000004083|UniProtKB=Q90855	AMPA receptor GluR1/A	ISS	12871085	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00010	B cell activation	P00381	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00778	NMDA receptor	CHICK|Ensembl=ENSGALG00000008898|UniProtKB=F1P2J9	Uncharacterized protein	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00010	B cell activation	P00371	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06860	Rac1	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	RCA	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00025	Hedgehog signaling pathway	P00691	CBP	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00859	NFkappaB	HUMAN|HGNC=9956|UniProtKB=Q01201	Transcription factor RelB	RCA			PTHR24169:SF18	TRANSCRIPTION FACTOR RELB
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04398	p53 pathway feedback loops 2	P04665	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04397	p53 pathway by glucose deprivation	P04640	p53	HUMAN|HGNC=12003|UniProtKB=O15350	Tumor protein p73	TAS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00010	B cell activation	P00391	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00030	Hypoxia response via HIF activation	P00814	P300	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00053	T cell activation	P01307	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IPI	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IC	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02738	De novo purine biosynthesis	P02898	Phosphoribosylformylglycinamide  synthase	HALSA|EnsemblGenome=VNG_0864G|UniProtKB=Q9HR49	Phosphoribosylformylglycinamidine synthase subunit PurL	ISS			PTHR43555:SF1	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	IC	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00038	JAK/STAT signaling pathway	P01030	SOCS	HUMAN|HGNC=19383|UniProtKB=O15524	Suppressor of cytokine signaling 1	ISS			PTHR44621:SF2	SUPPRESSOR OF CYTOKINE SIGNALING 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00006	Apoptosis signaling pathway	P00313	IKK	HUMAN|HGNC=5960|UniProtKB=O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00021	FGF signaling pathway	P00629	PP2A	MOUSE|MGI=MGI=1349473|UniProtKB=Q61151	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	ISS	11007767	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00029	Huntington disease	P00807	Actin	LEIMA|EnsemblGenome=LmjF.04.1230|UniProtKB=Q9U1E8	Actin	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	IC	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00047	PDGF signaling pathway	P01171	PLCgamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00019	Endothelin signaling pathway	P00572	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00010	B cell activation	P00388	PLC gamma2	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00736	CalDAG-GEF	HUMAN|HGNC=14545|UniProtKB=Q8IV61	Ras guanyl-releasing protein 3	ISS	10835426	PubMed	PTHR23113:SF178	RAS GUANYL-RELEASING PROTEIN 3
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DICDI|dictyBase=DDB_G0275023|UniProtKB=Q553U6	Putative actin-22	IDA	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04393	Ras Pathway	P04572	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	IDA	97102675	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00010	B cell activation	P00384	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IDA	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	RAT|RGD=2742|UniProtKB=P23385	Metabotropic glutamate receptor 1	ISS	8314195	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	SCHPO|PomBase=SPAC13F5.02c|UniProtKB=O13701	Transcription initiation factor TFIID subunit 7	ISS			PTHR12228:SF0	TAF7 RNA POLYMERASE II, TATA BOX BINDING PROTEIN  TBP -ASSOCIATED FACTOR
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000000365|UniProtKB=F6R9F4	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04396	Vitamin D metabolism and pathway	P04607	FDX	SCHPO|PomBase=SPAC22E12.10c|UniProtKB=Q10361	Electron transfer protein 1, mitochondrial	ISS			PTHR23289:SF2	CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HOMOLOG
P00018	EGF receptor signaling pathway	P00564	Rac	ENTHI|EnsemblGenome=EHI_197840|UniProtKB=C4M8K6	Rho family GTPase	IGI	8649368	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	RAT|RGD=1304749|UniProtKB=A0A0G2K0H3	Protein Lrp6	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P04393	Ras Pathway	P04559	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00034	Integrin signalling pathway	P00920	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P06664	Gonadotropin-releasing hormone receptor pathway	P06703	IGF-1R	MOUSE|MGI=MGI=96433|UniProtKB=Q60751	Insulin-like growth factor 1 receptor	RCA	249616	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000035697|UniProtKB=Q28024	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IDA	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	MOUSE|MGI=MGI=97852|UniProtKB=P62835	Ras-related protein Rap-1A	IDA	8576107	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P02762	Pentose phosphate pathway	P03079	Hexokinase	MACMU|Ensembl=ENSMMUG00000011845|UniProtKB=F7H4Y8	Uncharacterized protein	RCA			PTHR19443:SF4	HEXOKINASE-2
P02738	De novo purine biosynthesis	P02889	dGDP kinase	PSEAE|EnsemblGenome=PA3807|UniProtKB=Q59636	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	MACMU|Ensembl=ENSMMUG00000004657|UniProtKB=G7MVY8	Furin	ISS	11861638	PubMed	PTHR42884:SF1	FURIN
P00047	PDGF signaling pathway	P01173	STAT	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00034	Integrin signalling pathway	P00931	Integrin beta	HUMAN|HGNC=6163|UniProtKB=P26012	Integrin beta-8	IDA	3487386	PubMed	PTHR10082:SF9	INTEGRIN BETA-8
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00318	PKCs	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00047	PDGF signaling pathway	P01169	Vav	CAEEL|WormBase=WBGene00006887|UniProtKB=Q45FX5	Protein vav-1	ISS			PTHR22826:SF136	PROTEIN VAV
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	MOUSE|MGI=MGI=95791|UniProtKB=P05201	Aspartate aminotransferase, cytoplasmic	ISS			PTHR11879:SF3	ASPARTATE AMINOTRANSFERASE, CYTOPLASMIC
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	MACMU|Ensembl=ENSMMUG00000008351|UniProtKB=F7HRV5	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00046	Oxidative stress response	P01129	JNK1/2	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000025240|UniProtKB=F7A7I3	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00005	Angiogenesis	P00221	JNK1	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IDA	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00623	FGF	MACMU|Ensembl=ENSMMUG00000012484|UniProtKB=F7FAV0	Fibroblast growth factor	ISS	12496262	PubMed	PTHR11486:SF77	FIBROBLAST GROWTH FACTOR 13
P00047	PDGF signaling pathway	P01150	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00017	DNA replication	P00527	Histones	CAEBR|Gene=CBG03775|UniProtKB=G2J6F9	Histone H3	ISS	12413958	PubMed	PTHR11426:SF167	HISTONE H3.1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00276	TRAIL-R	PANTR|Ensembl=ENSPTRG00000020073|UniProtKB=H2QVW0	Uncharacterized protein	ISS	11498783	PubMed	PTHR23097:SF143	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10C-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	ISS	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	DANRE|ZFIN=ZDB-GENE-040116-1|UniProtKB=Q7ZUQ0	Actin related protein 2/3 complex, subunit 1A	ISS	12932731	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00018	EGF receptor signaling pathway	P00547	PP2A	ORYSJ|EnsemblGenome=OS03G0167700|UniProtKB=Q10R90	Serine/threonine-protein phosphatase	ISS			PTHR11668:SF265	SUBFAMILY NOT NAMED
P00054	Toll receptor signaling pathway	G01550	Gene trancription	BOVIN|Gene=IFNB3|UniProtKB=P01577	Interferon beta-3	ISS			PTHR11691:SF43	INTERFERON BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MACMU|Ensembl=ENSMMUG00000021610|UniProtKB=F7E433	Regulator of G-protein signaling 10 isoform a	ISS	8756726	PubMed	PTHR10845:SF182	REGULATOR OF G-PROTEIN SIGNALING 10
P00019	Endothelin signaling pathway	P00588	ET1-4	RAT|RGD=2532|UniProtKB=P22388	Endothelin-1	ISS	12773307	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P00030	Hypoxia response via HIF activation	P00814	P300	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00049	Parkinson disease	P01230	Src kinase	MACMU|Ensembl=ENSMMUG00000014635|UniProtKB=F7G2C9	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF296	TYROSINE-PROTEIN KINASE FRK
P00053	T cell activation	P01311	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IDA	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00233	CSL	MACMU|Ensembl=ENSMMUG00000015828|UniProtKB=F7CE90	Recombining binding protein suppressor of hairless isoform 4	ISS	15187023	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00034	Integrin signalling pathway	P00922	Collagen	RAT|RGD=621634|UniProtKB=B5DEG1	Protein Itga8	ISS			PTHR23220:SF5	INTEGRIN ALPHA-8
P00034	Integrin signalling pathway	P00916	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00048	PI3 kinase pathway	P01188	Gbetagamma	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	11313908	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MONDO|Ensembl=ENSMODG00000018204|UniProtKB=F6PGX6	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	CHICK|Ensembl=ENSGALG00000001334|UniProtKB=F1NLV4	Uncharacterized protein	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00036	Interleukin signaling pathway	P00986	eNOS	HUMAN|HGNC=7876|UniProtKB=P29474	Nitric oxide synthase, endothelial	ISS	9837777	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00053	T cell activation	P01332	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	DROME|FlyBase=FBgn0015278|UniProtKB=Q7K3H0	LD28067p	ISS	7937853	PubMed	PTHR10048:SF64	LD28067P
P06664	Gonadotropin-releasing hormone receptor pathway	P06798	PKCe/theta	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	RCA	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	DICDI|dictyBase=DDB_G0286555|UniProtKB=P34147	Rho-related protein racA	ISS			PTHR24072:SF183	RHO-RELATED PROTEIN RACA
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MACMU|Ensembl=ENSMMUG00000009679|UniProtKB=F6YBQ8	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00007	Axon guidance mediated by semaphorins	P00340	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00053	T cell activation	P01332	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04395	Vasopressin synthesis	P04599	Amidating Enzyme	MOUSE|MGI=MGI=97475|UniProtKB=P97467	Peptidyl-glycine alpha-amidating monooxygenase	IC	3153462	PubMed	PTHR10680:SF14	PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE
P00029	Huntington disease	P00805	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00465	TCF/LEF	PANTR|Ensembl=ENSPTRG00000012128|UniProtKB=H2QI87	Uncharacterized protein	ISS	12356903	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	ARATH|TAIR=AT1G48470|UniProtKB=Q8GXW5	Glutamine synthetase cytosolic isozyme 1-5	ISS			PTHR20852:SF79	GLUTAMINE SYNTHETASE CYTOSOLIC ISOZYME 1-1-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	MONDO|Ensembl=ENSMODG00000003244|UniProtKB=F6THF0	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CHICK|Ensembl=ENSGALG00000011809|UniProtKB=F1NMB0	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04398	p53 pathway feedback loops 2	P04665	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01150	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04393	Ras Pathway	P04557	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02756	N-acetylglucosamine metabolism	P03039	Glucosamine-1-phosphate acetyltransferase	GLOVI|EnsemblGenome=BAC88384|UniProtKB=Q7NNG8	Bifunctional protein GlmU	ISS			PTHR43584:SF3	BIFUNCTIONAL PROTEIN GLMU
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00054	Toll receptor signaling pathway	P01367	MKK3	RAT|RGD=1306620|UniProtKB=B1H230	Map2k3 protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	PSEAE|EnsemblGenome=PA3568|UniProtKB=P28812	Uncharacterized protein PA3568	ISS			PTHR43347:SF2	SUBFAMILY NOT NAMED
P00049	Parkinson disease	P01242	Casein kinase I	PANTR|Ensembl=ENSPTRG00000005793|UniProtKB=H2REV2	Uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF139	CASEIN KINASE I ISOFORM ALPHA-LIKE
P00047	PDGF signaling pathway	P01159	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P06959	CCKR signaling map	P07049	CK1	HUMAN|HGNC=2451|UniProtKB=P48729	Casein kinase I isoform alpha	RCA	18515095	PubMed	PTHR11909:SF84	CASEIN KINASE I ISOFORM ALPHA
P00021	FGF signaling pathway	P00629	PP2A	CHICK|Gene_ORFName=RCJMB04_22l15|UniProtKB=Q5ZIY5	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform	ISS	137056	PubMed	PTHR11871:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B DELTA ISOFORM
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	MACMU|Ensembl=ENSMMUG00000020819|UniProtKB=F7HSM1	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00046	Oxidative stress response	P01129	JNK1/2	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	TAS	10207617	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00052	TGF-beta signaling pathway	P01275	P38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	TAS	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00566	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	BOVIN|Ensembl=ENSBTAG00000025337|UniProtKB=F1MZX6	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF504	MYOSIN-13
P06959	CCKR signaling map	G07284	CLU	HUMAN|HGNC=2095|UniProtKB=P10909	Clusterin	RCA	21995960	PubMed	PTHR10970:SF1	CLUSTERIN
P00056	VEGF signaling pathway	P01413	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00048	PI3 kinase pathway	P01187	IR	PANTR|Ensembl=ENSPTRG00000010386|UniProtKB=H2QF61	Tyrosine-protein kinase receptor	ISS	11182407	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00251	cPLA2	RAT|RGD=67366|UniProtKB=P50393	Cytosolic phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00048	PI3 kinase pathway	P01187	IR	RAT|RGD=2917|UniProtKB=P15127	Insulin receptor	IDA	14500580	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	RCA	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00022	General transcription by RNA polymerase I	P00650	TAF-IB	XENTR|Xenbase=XB-GENE-491356|UniProtKB=Q28J24	Transcription initiation factor TFIID subunit 8	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00048	PI3 kinase pathway	P01177	P110ACT	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	15210700	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00021	FGF signaling pathway	P00623	FGF	PANTR|Ensembl=ENSPTRG00000022533|UniProtKB=H2R396	Fibroblast growth factor	ISS	12619867	PubMed	PTHR11486:SF27	FIBROBLAST GROWTH FACTOR 16
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	IC	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P02753	Methionine biosynthesis	P03024	Homocysteine transmethylase	MYCTU|EnsemblGenome=LH57_13435|UniProtKB=O53185	Homocysteine methyltransferase	ISS			PTHR21091:SF123	FI01821P
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	IDA	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=619745|UniProtKB=Q8R490	Cadherin 13	IDA	8120095	PubMed	PTHR24027:SF80	CADHERIN-13
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00011	Blood coagulation	P00444	FIX	MACMU|Ensembl=ENSMMUG00000020064|UniProtKB=F7GHR4	Uncharacterized protein	ISS	14270099	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P00005	Angiogenesis	P00235	c-Fos	TAKRU|Ensembl=ENSTRUG00000010431|UniProtKB=H2TNK9	Uncharacterized protein	ISS			PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00056	VEGF signaling pathway	P01414	PLC-gamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00717	Phosphorylase b	PANTR|Ensembl=ENSPTRG00000006337|UniProtKB=H2Q8A4	Alpha-1,4 glucan phosphorylase	ISS	4318782	PubMed	PTHR11468:SF12	GLYCOGEN PHOSPHORYLASE, LIVER FORM
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00021	FGF signaling pathway	P00624	14-3-3	MOUSE|MGI=MGI=109484|UniProtKB=P63101	14-3-3 protein zeta/delta	ISS	92362864	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05731	GABA-B receptor II signaling	P05755	Gbeta	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00053	T cell activation	P01300	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00951	Jnk	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IDA	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	9298898	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MONDO|Ensembl=ENSMODG00000008701|UniProtKB=F6PWM3	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF22	FRIZZLED-3
P00048	PI3 kinase pathway	P01177	P110ACT	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	SCHMA|EnsemblGenome=Smp_183710|UniProtKB=G4VLW1	Putative actin	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00046	Oxidative stress response	P01135	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	TAS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CANLF|Ensembl=ENSCAFG00000012181|UniProtKB=F2Z4N7	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05917	Opioid proopiomelanocortin pathway	P06009	K+ channel	PANTR|Ensembl=ENSPTRG00000020614|UniProtKB=H2QWR7	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	SCHPO|PomBase=SPAC1006.09|UniProtKB=O74304	MAP kinase kinase kinase win1	ISS			PTHR24361:SF433	PROTEIN MES-1
P00048	PI3 kinase pathway	P01192	p110	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00807	Actin	TRIAD|EnsemblGenome=TriadG63375|UniProtKB=B3S5E4	Non-muscle actin 6.2	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00059	p53 pathway	G01568	KILLER/DR5	PANTR|Ensembl=ENSPTRG00000020073|UniProtKB=H2QVW0	Uncharacterized protein	ISS	11498783	PubMed	PTHR23097:SF143	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10C-RELATED
P00046	Oxidative stress response	P01135	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02747	Histidine biosynthesis	P02990	Histidinol-phosphatase	BACTN|EnsemblGenome=BT_4257|UniProtKB=Q89ZW4	Putative histidinol-phosphatase	ISS			PTHR21039:SF0	HISTIDINOL-PHOSPHATASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	HUMAN|HGNC=5465|UniProtKB=P08069	Insulin-like growth factor 1 receptor	ISS	2877871	PubMed	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	THEMA|EnsemblGenome=TM_1351|UniProtKB=Q9X172	Glutamate--tRNA ligase 1	ISS			PTHR43311:SF2	GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000008719|UniProtKB=F1MZX0	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	YEAST|SGD=S000004779|UniProtKB=P54114	Aldehyde dehydrogenase [NAD(P)+] 2	IC			PTHR43720:SF1	ALDEHYDE DEHYDROGENASE  NAD P +  1-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	PANTR|Ensembl=ENSPTRG00000011049|UniProtKB=H2QGF9	Glycogen synthase kinase 3 alpha	ISS	14698990	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	RAT|RGD=3238|UniProtKB=P01179	Oxytocin-neurophysin 1	ISS	3768139	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P05731	GABA-B receptor II signaling	P05755	Gbeta	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	PANTR|Ensembl=ENSPTRG00000012508|UniProtKB=H2QIS5	Uncharacterized protein	ISS	11907044	PubMed	PTHR44025:SF7	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	CAEEL|WormBase=WBGene00003774|UniProtKB=G5EGQ9	NMDA class glutamate Receptor	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	BOVIN|Ensembl=ENSBTAG00000018445|UniProtKB=E1BK87	Uncharacterized protein	ISS	11554549	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	HUMAN|HGNC=9508|UniProtKB=P49768	Presenilin-1	IDA	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00006	Apoptosis signaling pathway	P00289	FAS	HUMAN|HGNC=11920|UniProtKB=P25445	Tumor necrosis factor receptor superfamily member 6	IDA	10327065	PubMed	PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P00021	FGF signaling pathway	P00641	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	HUMAN|HGNC=27309|UniProtKB=Q86XF0	Dihydrofolate reductase, mitochondrial	ISS			PTHR22778:SF26	DIHYDROFOLATE REDUCTASE, MITOCHONDRIAL
P02762	Pentose phosphate pathway	P03070	Gluconate Dehydrogenase	YEAST|SGD=S000001226|UniProtKB=P38720	6-phosphogluconate dehydrogenase, decarboxylating 1	ISS	8091229	PubMed	PTHR11811:SF25	6-PHOSPHOGLUCONATE DEHYDROGENASE, DECARBOXYLATING
P00052	TGF-beta signaling pathway	P01275	P38	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	TAS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00046	Oxidative stress response	P01135	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	TAS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00010	B cell activation	P00388	PLC gamma2	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00058	mRNA splicing	P01477	U2AF35	MOUSE|MGI=MGI=98885|UniProtKB=Q64707	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1	ISS			PTHR12620:SF2	U2 SMALL NUCLEAR RIBONUCLEOPROTEIN AUXILIARY FACTOR 35 KDA SUBUNIT-RELATED PROTEIN 1
P00021	FGF signaling pathway	P00641	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00010	B cell activation	P00369	MEKK	BOVIN|Ensembl=ENSBTAG00000004216|UniProtKB=F1MSX4	Uncharacterized protein	ISS	8621389	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00052	TGF-beta signaling pathway	P01284	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MONDO|Ensembl=ENSMODG00000020742|UniProtKB=F7A026	Uncharacterized protein	ISS	1333052	PubMed	PTHR24241:SF22	GONADOTROPIN-RELEASING HORMONE RECEPTOR
P00047	PDGF signaling pathway	P01175	Shc	RAT|RGD=69348|UniProtKB=O70143	SHC-transforming protein 3	ISS	9507002	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P00052	TGF-beta signaling pathway	G01548	I-SMAD	RAT|RGD=69314|UniProtKB=O88406	Mothers against decapentaplegic homolog 7	IGI	9335505	PubMed	PTHR13703:SF27	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 7
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	RAT|RGD=2518|UniProtKB=P18901	D(1A) dopamine receptor	ISS	9700720	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00005	Angiogenesis	P00243	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	12068308	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05913	Enkephalin release	P05972	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00018	EGF receptor signaling pathway	P00545	JNK1-3	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g188243|UniProtKB=A7SCN8	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014555|UniProtKB=F7GT55	Syntaxin-1A isoform 1	ISS	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00053	T cell activation	P01303	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	11384839	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04384	Gamma-aminobutyric acid synthesis	P04482	Glutamate decarboxylase	MONDO|Ensembl=ENSMODG00000008529|UniProtKB=F7DHD9	Uncharacterized protein	ISS	2247446	PubMed	PTHR11999:SF57	GLUTAMATE DECARBOXYLASE 1
P00046	Oxidative stress response	P01129	JNK1/2	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00052	TGF-beta signaling pathway	P01286	TGFbeta	CANLF|Ensembl=ENSCAFG00000003550|UniProtKB=E2QW13	Uncharacterized protein	ISS	11451570	PubMed	PTHR11848:SF133	INHIBIN BETA A CHAIN
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00038	JAK/STAT signaling pathway	P01027	STAT	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	ISS	12461178	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00006	Apoptosis signaling pathway	P00274	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	ISS	8946915	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MOUSE|MGI=MGI=1340026|UniProtKB=P33435	Collagenase 3	TAS	12834808	PubMed	PTHR10201:SF165	COLLAGENASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	HUMAN|HGNC=10452|UniProtKB=P31350	Ribonucleoside-diphosphate reductase subunit M2	ISS			PTHR23409:SF20	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00057	Wnt signaling pathway	P01455	Smad4	MONDO|Ensembl=ENSMODG00000015152|UniProtKB=F7CFQ6	Mothers against decapentaplegic homolog	ISS	12736218	PubMed	PTHR13703:SF36	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	RAT|RGD=2736|UniProtKB=P35439	Glutamate receptor ionotropic, NMDA 1	IC	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	14765990	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P02788	Xanthine and guanine salvage pathway	P03250	Guanosine phosphorylase	YEAST|SGD=S000004199|UniProtKB=Q05788	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000008270|UniProtKB=H2QBE5	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF319	CADHERIN-1
P00035	Interferon-gamma signaling pathway	P00961	STAT1	TAKRU|Ensembl=ENSTRUG00000000102|UniProtKB=H2RJA9	Signal transducer and activator of transcription	ISS	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00024	Glycolysis	P00679	Aldolase	RAT|RGD=2089|UniProtKB=P05065	Fructose-bisphosphate aldolase A	ISS	3391172	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00054	Toll receptor signaling pathway	P01375	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	ISS	97102676	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00018	EGF receptor signaling pathway	P00565	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	SCHPO|PomBase=SPAC458.05|UniProtKB=P50520	Phosphatidylinositol 3-kinase vps34	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04396	Vitamin D metabolism and pathway	P04607	FDX	CHICK|Gene=FDX1|UniProtKB=P13216	Adrenodoxin, mitochondrial (Fragment)	IDA	2969697	PubMed	PTHR23426:SF26	ADRENODOXIN, MITOCHONDRIAL
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00012	Cadherin signaling pathway	P00476	Yes	HUMAN|HGNC=6735|UniProtKB=P07948	Tyrosine-protein kinase Lyn	ISS			PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P04393	Ras Pathway	P04567	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00310	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00034	Integrin signalling pathway	P00906	Rap1	DANRE|ZFIN=ZDB-GENE-040625-167|UniProtKB=Q6IQP4	RAP1A, member of RAS oncogene family	ISS	8576107	PubMed	PTHR24070:SF284	RAP1A, MEMBER OF RAS ONCOGENE FAMILY
P00053	T cell activation	P01324	rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00018	EGF receptor signaling pathway	P00564	Rac	MONDO|Ensembl=ENSMODG00000025151|UniProtKB=F7CKV9	Uncharacterized protein	ISS			PTHR24072:SF150	RAS HOMOLOG GENE FAMILY, MEMBER GA-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	BOVIN|Ensembl=ENSBTAG00000027980|UniProtKB=Q17QQ4	Transcription initiation factor TFIID subunit 9	ISS			PTHR12595:SF8	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 9
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	BOVIN|Gene=MYH2|UniProtKB=Q9BE41	Myosin-2	ISS	10938134	PubMed	PTHR13140:SF385	MYOSIN-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000001187|UniProtKB=F6R8N9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00023	General transcription regulation	P00659	TFIIEbeta	YEAST|SGD=S000001770|UniProtKB=P36145	Transcription initiation factor IIE subunit beta	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P00012	Cadherin signaling pathway	P00465	TCF/LEF	DANRE|ZFIN=ZDB-GENE-980605-30|UniProtKB=Q9YHE8	Transcription factor 7-like 1-A	ISS	9118222	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	MACMU|Ensembl=ENSMMUG00000003275|UniProtKB=F7FKL1	Serine/threonine-protein kinase PAK 7	ISS			PTHR24361:SF183	SERINE/THREONINE-PROTEIN KINASE PAK 7
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-040426-2280|UniProtKB=Q6P025	Gnb3 protein	ISS			PTHR19850:SF35	GNB3 PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	HUMAN|HGNC=2213|UniProtKB=P12111	Collagen alpha-3(VI) chain	IC	10778855	PubMed	PTHR44105:SF2	COLLAGEN ALPHA-3 VI  CHAIN
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00021	FGF signaling pathway	P00623	FGF	MACMU|Ensembl=ENSMMUG00000009067|UniProtKB=F7F301	Fibroblast growth factor	ISS			PTHR11486:SF23	FIBROBLAST GROWTH FACTOR 5
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00050	Plasminogen activating cascade	P01255	Plasminogen	HUMAN|HGNC=6667|UniProtKB=P08519	Apolipoprotein(a)	ISS	88039109	PubMed	PTHR24261:SF2	APOLIPOPROTEIN A -RELATED
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	CANLF|Ensembl=ENSCAFG00000018144|UniProtKB=F1PNI3	Uncharacterized protein	ISS	4812352	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00054	Toll receptor signaling pathway	P01352	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00006	Apoptosis signaling pathway	P00316	Bcl-w	HUMAN|HGNC=42959|UniProtKB=Q92843	Bcl-2-like protein 2	IDA	8761287	PubMed	PTHR11256:SF13	BCL-2-LIKE PROTEIN 2
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01177	P110ACT	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00798	Clathrin	PANTR|Ensembl=ENSPTRG00000020930|UniProtKB=H2QX95	Uncharacterized protein	ISS	11889126	PubMed	PTHR10639:SF1	CLATHRIN LIGHT CHAIN A
P00049	Parkinson disease	P01230	Src kinase	MOUSE|MGI=MGI=98397|UniProtKB=P05480	Neuronal proto-oncogene tyrosine-protein kinase Src	IDA	8054685	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00011	Blood coagulation	P00458	GP IIIa	CANLF|Ensembl=ENSCAFG00000013735|UniProtKB=F1PPG5	Integrin beta	ISS	4206165	gi	PTHR10082:SF25	INTEGRIN BETA-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00036	Interleukin signaling pathway	P00976	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00054	Toll receptor signaling pathway	P01366	MKK4	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00036	Interleukin signaling pathway	P00983	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	CHICK|Ensembl=ENSGALG00000002932|UniProtKB=O57535	Nucleoside diphosphate kinase	ISS			PTHR11349:SF57	NUCLEOSIDE DIPHOSPHATE KINASE B
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00034	Integrin signalling pathway	P00941	Integrin alpha	HUMAN|HGNC=6141|UniProtKB=P08648	Integrin alpha-5	IPI	3487386	PubMed	PTHR23220:SF3	INTEGRIN ALPHA-5
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	FUSNN|EnsemblGenome=FN0421|UniProtKB=Q8RG87	Carbamoyl-phosphate synthase small chain	ISS			PTHR11405:SF4	CARBAMOYL-PHOSPHATE SYNTHASE ARGININE-SPECIFIC SMALL CHAIN
P00005	Angiogenesis	P00236	PI3K	CAEEL|WormBase=WBGene00006932|UniProtKB=Q9TXI7	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS			PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00011	Blood coagulation	P00407	PZ	BOVIN|Gene=PROZ|UniProtKB=P00744	Vitamin K-dependent protein Z	ISS			PTHR24278:SF20	VITAMIN K-DEPENDENT PROTEIN Z
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	7937853	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00034	Integrin signalling pathway	P00907	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	IDA	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MONDO|Ensembl=ENSMODG00000013079|UniProtKB=F7FB74	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MOUSE|MGI=MGI=1339709|UniProtKB=P13541	Myosin-3	ISS	10938134	PubMed	PTHR13140:SF427	MYOSIN-3
P00060	Ubiquitin proteasome pathway	P01491	E2	ARATH|TAIR=AT1G16890|UniProtKB=Q9FZ48	Ubiquitin-conjugating enzyme E2 36	ISS			PTHR43902:SF2	UBIQUITIN-CONJUGATING ENZYME E2 N
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	MOUSE|MGI=MGI=87887|UniProtKB=Q8R4G9	Neuronal acetylcholine receptor subunit alpha-3	ISS	85270494	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MACMU|Ensembl=ENSMMUG00000009679|UniProtKB=F6YBQ8	Uncharacterized protein	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00053	T cell activation	P01311	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IDA	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00586	Gq	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	ARATH|TAIR=AT2G41630|UniProtKB=P48512	Transcription initiation factor IIB-1	ISS			PTHR11618:SF37	CYCLIN FAMILY PROTEIN-RELATED
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	TAS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00018	EGF receptor signaling pathway	P00552	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IGI	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P04398	p53 pathway feedback loops 2	P04649	Myc	DANRE|ZFIN=ZDB-GENE-980526-499|UniProtKB=Q6P943	Signal transducer and activator of transcription	IC			PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	DROME|FlyBase=FBgn0015024|UniProtKB=P54367	Casein kinase I isoform alpha	IDA	11955435	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CANLF|Ensembl=ENSCAFG00000008756|UniProtKB=F2Z4N8	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IGI	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05729	Bupropion degradation	P05742	Cytochrome P450 2B6	HUMAN|HGNC=2615|UniProtKB=P20813	Cytochrome P450 2B6	TAS	10997944	PubMed	PTHR24300:SF153	CYTOCHROME P450 2B6
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DANRE|ZFIN=ZDB-GENE-030131-1229|UniProtKB=Q6DHS1	Actin, alpha 2, smooth muscle, aorta	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	TAS	12707323	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04496	Mdm2	CANLF|Ensembl=ENSCAFG00000009669|UniProtKB=E2RDT3	Uncharacterized protein	ISS			PTHR13844:SF20	PROTEIN MDM4
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	CANLF|Ensembl=ENSCAFG00000000643|UniProtKB=E2RSL8	Uncharacterized protein	ISS			PTHR11482:SF7	ANTIZYME INHIBITOR 1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	RAT|RGD=628596|UniProtKB=P69897	Tubulin beta-5 chain	ISS	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=103077|UniProtKB=Q64704	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00053	T cell activation	P01335	jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DANRE|ZFIN=ZDB-GENE-070112-342|UniProtKB=A1L271	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	BOVIN|Ensembl=ENSBTAG00000007599|UniProtKB=Q95KV0	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00047	PDGF signaling pathway	P01143	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	21071228	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00019	Endothelin signaling pathway	P00566	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00059	p53 pathway	G04694	p110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00269	MAPK	ORYSJ|EnsemblGenome=OS06G0154500|UniProtKB=Q84UI5	Mitogen-activated protein kinase 1	ISS	10851062	PubMed	PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P02747	Histidine biosynthesis	P02989	Phosphoribosyl AMP cyclohydrolase	AQUAE|EnsemblGenome=aq_1968|UniProtKB=O67780	Histidine biosynthesis bifunctional protein HisIE	ISS			PTHR42945:SF1	HISTIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN HISIE, CHLOROPLASTIC
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05913	Enkephalin release	P05977	G-Protein (s)	BOVIN|Ensembl=ENSBTAG00000006495|UniProtKB=P11017	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00010	B cell activation	P00381	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	IGI	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00029	Huntington disease	P00811	Arp2/3 complex	ARATH|TAIR=AT2G31300|UniProtKB=Q9SJW6	Actin-related protein 2/3 complex subunit 1B	TAS	12963527	gi	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P00049	Parkinson disease	P01238	14-3-3	CANLF|Ensembl=ENSCAFG00000000580|UniProtKB=F1PBL1	Uncharacterized protein	ISS	92283271	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00034	Integrin signalling pathway	P00947	Laminin	DROME|FlyBase=FBgn0002526|UniProtKB=Q00174	Laminin subunit alpha	IPI	2538453	PubMed	PTHR10574:SF359	LAMININ SUBUNIT ALPHA-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00056	VEGF signaling pathway	P01413	PI3K	ANOGA|EnsemblGenome=AGAP011036|UniProtKB=A0NBA9	AGAP011036-PA (Fragment)	ISS	7937853	PubMed	PTHR10048:SF64	LD28067P
P00060	Ubiquitin proteasome pathway	P01490	E3	HUMAN|HGNC=12471|UniProtKB=P41226	Ubiquitin-like modifier-activating enzyme 7	ISS			PTHR10953:SF143	UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 7
P00012	Cadherin signaling pathway	P00470	F-actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g234494|UniProtKB=A7RU31	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00018	EGF receptor signaling pathway	P00545	JNK1-3	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02748	Isoleucine biosynthesis	P02996	Ketol-acid reductoisomerase	DEIRA|EnsemblGenome=DR_1519|UniProtKB=Q9RU74	Ketol-acid reductoisomerase	ISS			PTHR21371:SF1	KETOL-ACID REDUCTOISOMERASE, CHLOROPLASTIC
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00029	Huntington disease	P00787	MAPKK4	PANTR|Ensembl=ENSPTRG00000008783|UniProtKB=H2QCA7	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	HUMAN|HGNC=4584|UniProtKB=Q05586	Glutamate receptor ionotropic, NMDA 1	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04558	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05731	GABA-B receptor II signaling	P05752	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05913	Enkephalin release	P05973	GPCR (i)	DANRE|ZFIN=ZDB-GENE-990415-199|UniProtKB=A3QJX7	Uncharacterized protein	ISS	11259498	PubMed	PTHR24229:SF74	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00118	E-cadherin	MACMU|Ensembl=ENSMMUG00000010393|UniProtKB=F7D992	Uncharacterized protein	ISS	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P00036	Interleukin signaling pathway	P00962	ELK	MACMU|Ensembl=ENSMMUG00000018145|UniProtKB=F7F772	ETS domain-containing protein Elk-3	ISS			PTHR11849:SF172	ETS DOMAIN-CONTAINING PROTEIN ELK-3
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=621787|UniProtKB=O88278	Cadherin EGF LAG seven-pass G-type receptor 3	IDA	8120095	PubMed	PTHR24026:SF38	CADHERIN EGF LAG SEVEN-PASS G-TYPE RECEPTOR 3
P05915	Opioid proenkephalin pathway	P05990	K+ channel	MACMU|Ensembl=ENSMMUG00000005826|UniProtKB=F6VE51	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P02785	Valine biosynthesis	P03218	Dihydroxy isovalerate dehydratase	RHOBA|EnsemblGenome=RB12087|UniProtKB=Q7UJ69	Dihydroxy-acid dehydratase	ISS			PTHR21000:SF5	DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL
P00046	Oxidative stress response	P01124	Myc	STRPU|EnsemblGenome=SPU_003166|UniProtKB=W4XIE2	Uncharacterized protein	TAS			PTHR11514:SF95	MYC PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	HUMAN|HGNC=9857|UniProtKB=P61224	Ras-related protein Rap-1b	IDA	1904317	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00029	Huntington disease	P00775	Rac	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS			PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	10755300	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	IDA	12846562	PubMed	PTHR10202:SF13	PRESENILIN-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	ORNAN|Ensembl=ENSOANG00000002226|UniProtKB=F6TPX7	Ribosomal protein S6 kinase	ISS	15116068	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00036	Interleukin signaling pathway	P00965	ERK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00048	PI3 kinase pathway	P01179	PKB	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	TAS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MOUSE|MGI=MGI=2444552|UniProtKB=Q8BFZ3	Beta-actin-like protein 2	IC	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05923	beta-ARR2	HUMAN|HGNC=712|UniProtKB=P32121	Beta-arrestin-2	RCA	11742073	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00021	FGF signaling pathway	P00643	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02728	Arginine biosynthesis	P02847	N-actetylornithine deacetylase	DICDI|dictyBase=DDB_G0267380|UniProtKB=P54638	Acetylornithine deacetylase	ISS			PTHR43808:SF3	ACETYLORNITHINE DEACETYLASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ORYSJ|EnsemblGenome=OS05G0438800|UniProtKB=Q75HX0	Actin	IC	14684598	PubMed	PTHR11937:SF248	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00059	p53 pathway	P04630	PP2A	MOUSE|MGI=MGI=1321161|UniProtKB=P62715	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	USTMA|Gene=UMAG_03910|UniProtKB=A0A0D1DU81	Chromosome 11, whole genome shotgun sequence	ISS	9753452	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00019	Endothelin signaling pathway	P00577	PI3K	ARATH|TAIR=AT1G60490|UniProtKB=P42339	Phosphatidylinositol 3-kinase VPS34	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P02772	Pyruvate metabolism	P03139	Lactate Dehydrogenase	TRIVA|Gene=TVAG_534540|UniProtKB=A2GET8	L-lactate dehydrogenase, putative	IDA	10339579	PubMed	PTHR23382:SF0	MALATE DEHYDROGENASE 2, MITOCHONDRIAL-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ORNAN|Ensembl=ENSOANG00000000460|UniProtKB=F7F4W9	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00029	Huntington disease	P00790	beta-Tubulin	DANRE|ZFIN=ZDB-GENE-030131-7741|UniProtKB=Q6PE34	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF93	SUBFAMILY NOT NAMED
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	9395335	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	LEIMA|EnsemblGenome=LmjF.18.1080|UniProtKB=Q27687	Protein kinase A catalytic subunit	IC	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00010	B cell activation	P00367	NFAT	HUMAN|HGNC=7777|UniProtKB=Q12968	Nuclear factor of activated T-cells, cytoplasmic 3	IDA	9133421	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00060	Ubiquitin proteasome pathway	P01490	E3	DANRE|ZFIN=ZDB-GENE-030131-1830|UniProtKB=A9JRZ0	E3 ubiquitin-protein ligase SMURF2	ISS	11252892	PubMed	PTHR11254:SF300	E3 UBIQUITIN-PROTEIN LIGASE SMURF2
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00627	ERK1-2	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00012	Cadherin signaling pathway	P00473	P120	MONDO|Ensembl=ENSMODG00000020116|UniProtKB=F7E9X7	Uncharacterized protein	ISS			PTHR10372:SF6	CATENIN DELTA-1
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00018	EGF receptor signaling pathway	P00552	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IGI	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P02723	Adenine and hypoxanthine salvage pathway	P02812	Deoxyinosine phosphorylase	MACMU|Ensembl=ENSMMUG00000019126|UniProtKB=F6T0Z6	Purine nucleoside phosphorylase	ISS			PTHR11904:SF12	PURINE NUCLEOSIDE PHOSPHORYLASE
P00029	Huntington disease	P00775	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P02726	Aminobutyrate degradation	P02825	4-aminobutyrate aminotransferase	RAT|RGD=620948|UniProtKB=P50554	4-aminobutyrate aminotransferase, mitochondrial	ISS	10989446	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05917	Opioid proopiomelanocortin pathway	P06008	ACTH	MONDO|Ensembl=ENSMODG00000015853|UniProtKB=Q95J84	Proopiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P05731	GABA-B receptor II signaling	P05752	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00056	VEGF signaling pathway	P01414	PLC-gamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	HUMAN|HGNC=20637|UniProtKB=Q9BPU6	Dihydropyrimidinase-related protein 5	IPI	10851247	PubMed	PTHR11647:SF58	DIHYDROPYRIMIDINASE-RELATED PROTEIN 5
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P02741	Flavin biosynthesis	P02934	Riboflavin kinase	NEUCR|EnsemblGenome=EFNCRG00000003534|UniProtKB=Q6M923	Riboflavin kinase	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P00048	PI3 kinase pathway	P01192	p110	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MOUSE|MGI=MGI=95777|UniProtKB=Q6R0H7	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00049	Parkinson disease	P01238	14-3-3	MOUSE|MGI=MGI=109194|UniProtKB=P68510	14-3-3 protein eta	IDA	10407019	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P02747	Histidine biosynthesis	P02991	Histidinephosphate aminotransferase	FUSNN|EnsemblGenome=FN0973|UniProtKB=Q8REW4	Histidinol-phosphate aminotransferase	ISS			PTHR42885:SF1	SUBFAMILY NOT NAMED
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05913	Enkephalin release	P05972	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00012	Cadherin signaling pathway	P00473	P120	RAT|RGD=620734|UniProtKB=O35116	Catenin delta-2 (Fragment)	ISS			PTHR10372:SF9	CATENIN DELTA-2
P06587	Nicotine pharmacodynamics pathway	P06606	ADCY2	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	XENTR|GeneID=394982|UniProtKB=P20399	Actin, alpha cardiac muscle 2	ISS	14684598	PubMed	PTHR11937:SF263	ACTIN
P05918	p38 MAPK pathway	P05920	MAPKAP-K2	BOVIN|Ensembl=ENSBTAG00000038107|UniProtKB=F1MCX5	Uncharacterized protein	ISS	7923354	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P05915	Opioid proenkephalin pathway	P05987	peptide F	MACMU|Ensembl=ENSMMUG00000006775|UniProtKB=F7H3N8	Uncharacterized protein	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Ensembl=ENSPTRG00000000543|UniProtKB=H2PYN8	Uncharacterized protein	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00053	T cell activation	P01311	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	3449797	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	CAEBR|Gene=CBG18174|UniProtKB=A8XT67	Protein CBR-ARX-3	ISS	12932731	PubMed	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P00021	FGF signaling pathway	P00636	FGFR1-4	CANLF|Ensembl=ENSCAFG00000016518|UniProtKB=F6XBX5	Fibroblast growth factor receptor	ISS	93194827	PubMed	PTHR24416:SF343	FIBROBLAST GROWTH FACTOR RECEPTOR 4
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	11035810	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00623	FGF	HUMAN|HGNC=3684|UniProtKB=P10767	Fibroblast growth factor 6	ISS			PTHR11486:SF25	FIBROBLAST GROWTH FACTOR 6
P00019	Endothelin signaling pathway	P00591	PLCbeta	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IGI	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02916	dTMP kinase	YEAST|SGD=S000003818|UniProtKB=P00572	Thymidylate kinase	ISS			PTHR10344:SF1	THYMIDYLATE KINASE
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	ARATH|TAIR=AT3G20550|UniProtKB=Q8W4D8	FHA domain-containing protein DDL	ISS			PTHR23308:SF36	SMAD NUCLEAR-INTERACTING PROTEIN 1
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	IDA	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00021	FGF signaling pathway	P00646	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	2574500	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00048	PI3 kinase pathway	P01198	FOXO	MOUSE|MGI=MGI=1890081|UniProtKB=Q9WVH4	Forkhead box protein O3	TAS	15031210	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	HUMAN|HGNC=4594|UniProtKB=Q14416	Metabotropic glutamate receptor 2	ISS	12351712	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00021	FGF signaling pathway	P00640	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00022	General transcription by RNA polymerase I	P00652	RNA Polymerase I  Complex	CANLF|Ensembl=ENSCAFG00000006755|UniProtKB=E2RI73	Uncharacterized protein	ISS	12446911	PubMed	PTHR13946:SF28	DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2
P00057	Wnt signaling pathway	P01444	Wnt	BOVIN|Ensembl=ENSBTAG00000008097|UniProtKB=A4D7S0	Protein Wnt-2	ISS	11266476	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00019	Endothelin signaling pathway	P00589	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00398	IP3R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00053	T cell activation	P01332	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00785	Cytochrome c	ORYSJ|EnsemblGenome=OS01G0935700|UniProtKB=Q942X6	Os01g0935700 protein	IDA	9027315	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00047	PDGF signaling pathway	P01159	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04398	p53 pathway feedback loops 2	P04665	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01159	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	PANTR|Ensembl=ENSPTRG00000016548|UniProtKB=H2QQC5	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PUCGT|EnsemblGenome=PGTG_05488|UniProtKB=E3K4I1	Actin	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00048	PI3 kinase pathway	G01545	scl-1	CAEEL|WormBase=WBGene00008028|UniProtKB=Q18538	SCP-Like extracellular protein	ISS			PTHR10334:SF167	SCP-LIKE EXTRACELLULAR PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00048	PI3 kinase pathway	P01190	PDK1 ACT	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05731	GABA-B receptor II signaling	P05760	AC	PANTR|Ensembl=ENSPTRG00000006216|UniProtKB=H2Q832	Adenylate cyclase 4	ISS	1946437	PubMed	PTHR11920:SF286	ADENYLATE CYCLASE TYPE 4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	MOUSE|MGI=MGI=2384786|UniProtKB=Q91XE9	Cyclic AMP-responsive element-binding protein 3-like protein 3	RCA			PTHR22952:SF98	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 3
P00011	Blood coagulation	P00423	APC	HUMAN|HGNC=9451|UniProtKB=P04070	Vitamin K-dependent protein C	ISS	4506115	gi	PTHR24278:SF0	VITAMIN K-DEPENDENT PROTEIN C
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	MOUSE|MGI=MGI=2661081|UniProtKB=Q8K348	Activin receptor type-1C	ISS			PTHR23255:SF58	ACTIVIN RECEPTOR TYPE-1C
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P02738	De novo purine biosynthesis	P02901	Adenosuccinate lyase	SYNY3|EnsemblGenome=BAA18481|UniProtKB=P74384	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P04393	Ras Pathway	P04556	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02746	Heme biosynthesis	P02972	Ferrochelatase	CHLTR|EnsemblGenome=CT_485|UniProtKB=O84492	Ferrochelatase	ISS			PTHR11108:SF1	FERROCHELATASE, MITOCHONDRIAL
P00021	FGF signaling pathway	P00627	ERK1-2	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	IGI	10514528	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IC	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00029	Huntington disease	P00768	Apaf-1	BOVIN|Ensembl=ENSBTAG00000021661|UniProtKB=F1MUW4	Apoptotic protease-activating factor 1	ISS	9267021	PubMed	PTHR22845:SF5	APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
P00034	Integrin signalling pathway	P00936	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IPI	10799299	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00006	Apoptosis signaling pathway	P00321	HSP70	RAT|RGD=2840|UniProtKB=P0DMW1	Heat shock 70 kDa protein 1B	ISS	12150907	PubMed	PTHR19375:SF223	HEAT SHOCK 70 KDA PROTEIN 1A-RELATED
P00049	Parkinson disease	P01208	Hsp70	DICPU|Gene=DICPUDRAFT_49867|UniProtKB=F0ZVR4	Heat shock protein	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P05734	Synaptic vesicle trafficking	P05779	Synaptobrevin	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IDA	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CHLRE|EnsemblGenome=CHLREDRAFT_24392|UniProtKB=A8JAV1	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04398	p53 pathway feedback loops 2	P04651	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IDA	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00053	T cell activation	P01312	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	MOUSE|MGI=MGI=95816|UniProtKB=B1AS29	Glutamate receptor ionotropic, kainate 3	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CAEBR|Gene=CBG17587|UniProtKB=A8XRA5	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00012	Cadherin signaling pathway	P00462	Casein kinase II	MONDO|Ensembl=ENSMODG00000015287|UniProtKB=F6T6M8	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00006	Apoptosis signaling pathway	P00318	PKCs	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	IDA	15572354	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00029	Huntington disease	P00799	JNK-2	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00012	Cadherin signaling pathway	P00464	Fyn	MONDO|Ensembl=ENSMODG00000017905|UniProtKB=F7FG65	Tyrosine-protein kinase	ISS	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	HUMAN|HGNC=10430|UniProtKB=Q15418	Ribosomal protein S6 kinase alpha-1	ISS	2779569	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000010392|UniProtKB=F7ASR8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00008	Axon guidance mediated by Slit/Robo	P00342	Slit	HUMAN|HGNC=11087|UniProtKB=O75094	Slit homolog 3 protein	ISS			PTHR24373:SF15	SLIT HOMOLOG 3 PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P02749	Leucine biosynthesis	P03002	Isopropylmalate isomerase	PSEAE|EnsemblGenome=PA3120|UniProtKB=Q9HZA4	3-isopropylmalate dehydratase small subunit	ISS			PTHR43345:SF2	3-ISOPROPYLMALATE DEHYDRATASE SMALL SUBUNIT
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05957	K+ channel	CHICK|Ensembl=ENSGALG00000016193|UniProtKB=E1BYI0	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P06210	Activin beta signaling pathway	P06231	BABO	DROME|FlyBase=FBgn0011300|UniProtKB=A1Z7L8	Receptor protein serine/threonine kinase	IEA	http://www.reactome.org/	Website	PTHR23255:SF71	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00057	Wnt signaling pathway	P01444	Wnt	RAT|RGD=1308057|UniProtKB=F1M077	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00047	PDGF signaling pathway	P01151	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00922	Collagen	RAT|RGD=1565398|UniProtKB=D3ZUL3	Protein Col6a1	ISS	10778855	PubMed	PTHR44172:SF3	COLLAGEN ALPHA-1 VI  CHAIN
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00029	Huntington disease	P00766	Htt	HUMAN|HGNC=4851|UniProtKB=P42858	Huntingtin	IDA	8268927	PubMed	PTHR10170:SF10	HUNTINGTIN
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MONDO|Ensembl=ENSMODG00000001807|UniProtKB=F6Y7R9	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P04398	p53 pathway feedback loops 2	P04668	p53	MOUSE|MGI=MGI=1330810|UniProtKB=O88898	Tumor protein 63	TAS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00021	FGF signaling pathway	P00628	JNK1-3	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS			PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	IC	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00470	F-actin	MACMU|Ensembl=ENSMMUG00000007027|UniProtKB=F7F210	Alpha-cardiac actin	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00005	Angiogenesis	P00227	PLA2	PANTR|Ensembl=ENSPTRG00000001787|UniProtKB=H2Q0T0	Phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00036	Interleukin signaling pathway	P00965	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00374	Lyn	BOVIN|Ensembl=ENSBTAG00000020034|UniProtKB=F1N261	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=1197020|UniProtKB=O35468	Protein Wnt-9b	TAS	11266476	PubMed	PTHR12027:SF84	PROTEIN WNT-9B
P00023	General transcription regulation	P00661	TTF2	MOUSE|MGI=MGI=3704243|UniProtKB=B9EJ57	Transcription termination factor 1b, mitochondrial	ISS			PTHR15437:SF2	TRANSCRIPTION TERMINATION FACTOR 1, MITOCHONDRIAL
P00049	Parkinson disease	P01211	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04542	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00785	Cytochrome c	CAEBR|Gene=CBG08212|UniProtKB=A8X623	Protein CBR-CYC-1	ISS	15163634	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	MOUSE|MGI=MGI=104742|UniProtKB=P63250	G protein-activated inward rectifier potassium channel 1	IDA	2433589	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	HUMAN|HGNC=1885|UniProtKB=P01215	Glycoprotein hormones alpha chain	ISS	89325834	PubMed	PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P00025	Hedgehog signaling pathway	P00692	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00005	Angiogenesis	P00235	c-Fos	PANTR|Ensembl=ENSPTRG00000006553|UniProtKB=A5A6H0	C-fos	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	CANLF|Ensembl=ENSCAFG00000015213|UniProtKB=E2RB82	Signal transducer and activator of transcription	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00059	p53 pathway	P01486	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00545	JNK1-3	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	ARATH|TAIR=AT1G16710|UniProtKB=Q9FWQ5	Histone acetyltransferase HAC12	TAS	10823891	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05918	p38 MAPK pathway	P06026	MEKK4	BOVIN|Ensembl=ENSBTAG00000020079|UniProtKB=F1N3T0	Uncharacterized protein	ISS	12878610	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P04393	Ras Pathway	P04547	Ras	MONDO|Ensembl=ENSMODG00000025248|UniProtKB=F7F5X1	Uncharacterized protein	ISS	3023884	PubMed	PTHR24070:SF186	GTPASE KRAS
P02738	De novo purine biosynthesis	P02899	GMP synthase	MONDO|Ensembl=ENSMODG00000015770|UniProtKB=F6ZS89	Uncharacterized protein	ISS			PTHR11922:SF2	GMP SYNTHASE  GLUTAMINE-HYDROLYZING
P00034	Integrin signalling pathway	P00916	Ras	CAEBR|Gene=CBG06092|UniProtKB=A8X0X5	Protein CBR-LET-60	ISS	12024031	PubMed	PTHR24070:SF385	GTPASE HRAS
P00006	Apoptosis signaling pathway	P00318	PKCs	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	IDA	10747026	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	CANLF|Ensembl=ENSCAFG00000015213|UniProtKB=E2RB82	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MONDO|Ensembl=ENSMODG00000009618|UniProtKB=F6REU0	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00015	Circadian clock system	G01497	cry	DROME|FlyBase=FBgn0025680|UniProtKB=O77059	Cryptochrome-1	IDA	10839367	PubMed	PTHR11455:SF17	CRYPTOCHROME-1
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	HUMAN|HGNC=4587|UniProtKB=Q14957	Glutamate receptor ionotropic, NMDA 2C	ISS	14698601	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00011	Blood coagulation	P00430	FX	MACMU|Ensembl=ENSMMUG00000001038|UniProtKB=F6SHG6	Uncharacterized protein	ISS	4503625	gi	PTHR44064:SF3	COAGULATION FACTOR X
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00018	EGF receptor signaling pathway	P00551	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	IGI	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_94959|UniProtKB=C3XYC4	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00056	VEGF signaling pathway	P01414	PLC-gamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00021	FGF signaling pathway	P00627	ERK1-2	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00036	Interleukin signaling pathway	P00966	mTOR	RAT|RGD=68371|UniProtKB=P42346	Serine/threonine-protein kinase mTOR	IGI	7518356	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00010	B cell activation	P00375	Calmodulin	DANRE|Ensembl=ENSDARG00000015050|UniProtKB=Q6PI52	Calmodulin	ISS	3885394	PubMed	PTHR23050:SF326	CALMODULIN
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	TAKRU|Ensembl=ENSTRUG00000007989|UniProtKB=P68140	Actin, alpha skeletal muscle A	ISS	10974003	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P04393	Ras Pathway	P04542	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01407	Erk	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	MOUSE|MGI=MGI=1095407|UniProtKB=O35607	Bone morphogenetic protein receptor type-2	TAS	9395284	PubMed	PTHR23255:SF63	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-2
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEEL|WormBase=WBGene00004033|UniProtKB=P90980	Protein kinase C-like 2	IC	3045562	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000019524|UniProtKB=F7CX56	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF71	PROTOCADHERIN BETA-16
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BOVIN|Ensembl=ENSBTAG00000000820|UniProtKB=Q5E9F0	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	ISS			PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MONDO|Ensembl=ENSMODG00000025248|UniProtKB=F7F5X1	Uncharacterized protein	ISS	3023884	PubMed	PTHR24070:SF186	GTPASE KRAS
P00036	Interleukin signaling pathway	P00976	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IPI	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00053	T cell activation	P01332	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00021	FGF signaling pathway	P00632	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IGI	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_58093|UniProtKB=C3Z4K3	Putative uncharacterized protein	IDA	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00005	Angiogenesis	P00223	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00020	FAS signaling pathway	P00615	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00018	EGF receptor signaling pathway	P00548	RKIP	MACMU|Ensembl=ENSMMUG00000005098|UniProtKB=F5CI18	Phosphatidylethanolamine-binding protein	ISS	94311839	PubMed	PTHR11362:SF28	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P00012	Cadherin signaling pathway	P00470	F-actin	ORNAN|Ensembl=ENSOANG00000007581|UniProtKB=F6QWB7	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=12774|UniProtKB=P04628	Proto-oncogene Wnt-1	TAS	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	IDA	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MONDO|Ensembl=ENSMODG00000014736|UniProtKB=F6ZC55	Phosphoinositide phospholipase C	ISS			PTHR10336:SF84	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IDA	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00029	Huntington disease	P00771	Sin3A	HUMAN|HGNC=19353|UniProtKB=Q96ST3	Paired amphipathic helix protein Sin3a	ISS	10441327	PubMed	PTHR12346:SF2	PAIRED AMPHIPATHIC HELIX PROTEIN SIN3A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00029	Huntington disease	P00790	beta-Tubulin	HUMAN|HGNC=20771|UniProtKB=P68371	Tubulin beta-4B chain	TAS	12932731	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00012	Cadherin signaling pathway	P00470	F-actin	EMENI|EnsemblGenome=CADANIAG00007315|UniProtKB=P20359	Actin, gamma	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00006	Apoptosis signaling pathway	P00302	ATF	MONDO|Ensembl=ENSMODG00000005909|UniProtKB=F6XD14	Uncharacterized protein	ISS			PTHR23351:SF10	JUN DIMERIZATION PROTEIN 2
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00006	Apoptosis signaling pathway	P00269	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02747	Histidine biosynthesis	P02991	Histidinephosphate aminotransferase	HALSA|EnsemblGenome=VNG_1033G|UniProtKB=Q9HQS0	Histidinol-phosphate aminotransferase	ISS			PTHR11751:SF430	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00787	MAPKK4	CANLF|Ensembl=ENSCAFG00000017851|UniProtKB=F1PBB6	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00054	Toll receptor signaling pathway	P01375	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00030	Hypoxia response via HIF activation	P00823	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	7937853	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01155	Jak	BOVIN|Ensembl=ENSBTAG00000012047|UniProtKB=E1BCP6	Tyrosine-protein kinase	ISS	22482294	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00021	FGF signaling pathway	P00638	PLCgamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00944	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g234494|UniProtKB=A7RU31	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	HUMAN|HGNC=4543|UniProtKB=P32298	G protein-coupled receptor kinase 4	RCA			PTHR24355:SF14	G PROTEIN-COUPLED RECEPTOR KINASE 4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	XENTR|Xenbase=XB-GENE-957124|UniProtKB=F7BDN8	Uncharacterized protein	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	THEMA|EnsemblGenome=TM_0813|UniProtKB=Q9WZS0	Glucosamine-6-phosphate deaminase [isomerizing], alternative	ISS			PTHR10937:SF4	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	HALSA|EnsemblGenome=VNG_0161G|UniProtKB=P0DMG4	Glutamate dehydrogenase B	ISS			PTHR11606:SF13	GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	CANLF|Ensembl=ENSCAFG00000012923|UniProtKB=F1PEK4	Uncharacterized protein	ISS			PTHR44107:SF3	DOWN SYNDROME CELL ADHESION MOLECULE-LIKE PROTEIN 1
P00020	FAS signaling pathway	P00620	CytochromeC	PSEAE|EnsemblGenome=PA4429|UniProtKB=Q9HVY6	Probable cytochrome c1	IGI	9027315	PubMed	PTHR10266:SF4	SUBFAMILY NOT NAMED
P05918	p38 MAPK pathway	P06043	ASK1	MOUSE|MGI=MGI=1346876|UniProtKB=O35099	Mitogen-activated protein kinase kinase kinase 5	TAS	12697749	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P02750	Lipoate_biosynthesis	P03004	Lipoate synthase	SCHPO|PomBase=SPBC8D2.15|UniProtKB=O13642	Lipoyl synthase, mitochondrial	ISS			PTHR10949:SF0	LIPOYL SYNTHASE, MITOCHONDRIAL
P00018	EGF receptor signaling pathway	P00551	Akt	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	ISS	21291563	gi	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04393	Ras Pathway	P04541	p90RSK	RAT|RGD=1563860|UniProtKB=D3Z8E0	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00371	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00049	Parkinson disease	P01211	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00798	Clathrin	MOUSE|MGI=MGI=894297|UniProtKB=O08585	Clathrin light chain A	ISS	11889126	PubMed	PTHR10639:SF1	CLATHRIN LIGHT CHAIN A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	CHICK|Ensembl=ENSGALG00000008591|UniProtKB=E1BZF6	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00057	Wnt signaling pathway	P01446	Calcineurin	RAT|RGD=69232|UniProtKB=P28470	Calcineurin subunit B type 2	IDA	12015605	PubMed	PTHR23056:SF42	CALCINEURIN SUBUNIT B TYPE 2
P05915	Opioid proenkephalin pathway	P05994	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MOUSE|MGI=MGI=95777|UniProtKB=Q6R0H7	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00060	Ubiquitin proteasome pathway	P01494	19S proteasome	PHYPA|Gene=PHYPADRAFT_164900|UniProtKB=A9SHI2	Predicted protein	ISS			PTHR23073:SF8	26S PROTEASE REGULATORY SUBUNIT 6B
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P02769	Purine metabolism	P03116	Xanthine Oxidase	MACMU|Ensembl=ENSMMUG00000000561|UniProtKB=F6Y3F0	Uncharacterized protein	ISS	8135849	PubMed	PTHR11908:SF80	XANTHINE DEHYDROGENASE/OXIDASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	RAT|RGD=619965|UniProtKB=P26769	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P05916	Opioid prodynorphin pathway	P06002	G-protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	HUMAN|HGNC=5301|UniProtKB=P50406	5-hydroxytryptamine receptor 6	IDA	12181435	PubMed	PTHR24247:SF114	5-HYDROXYTRYPTAMINE RECEPTOR 6
P00049	Parkinson disease	P01219	SAPK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	NAS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00053	T cell activation	P01305	Calmodulin	LEIMA|EnsemblGenome=LmjF.09.0910|UniProtKB=Q4QHT2	Putative calmodulin	ISS			PTHR23050:SF245	AT16150P-RELATED
P04397	p53 pathway by glucose deprivation	P04640	p53	DANRE|ZFIN=ZDB-GENE-990415-270|UniProtKB=P79734	Cellular tumor antigen p53	TAS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00010	B cell activation	P00367	NFAT	MACMU|Ensembl=ENSMMUG00000003370|UniProtKB=F7E8G2	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P02775	Salvage pyrimidine ribonucleotides	P03155	Cytosine deaminase	METAC|EnsemblGenome=MA_3407|UniProtKB=Q8TKJ8	Cytidine/deoxycytidylate deaminase family protein	ISS			PTHR44192:SF2	SUBFAMILY NOT NAMED
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00045	Notch signaling pathway	P01119	NIct	RAT|RGD=3188|UniProtKB=Q9QW30	Neurogenic locus notch homolog protein 2	IEP	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00005	Angiogenesis	P00203	Erk	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00021	FGF signaling pathway	P00644	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IGI	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MACMU|Ensembl=ENSMMUG00000022319|UniProtKB=F6XDA0	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P04398	p53 pathway feedback loops 2	P04668	p53	RAT|RGD=1307083|UniProtKB=D4AA88	Protein Tp73	ISS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00034	Integrin signalling pathway	P00922	Collagen	PANTR|Ensembl=ENSPTRG00000018351|UniProtKB=H2QTA4	Collagen, type XII, alpha 1	ISS	10778855	PubMed	PTHR45047:SF2	COLLAGEN ALPHA-1 XII  CHAIN
P02738	De novo purine biosynthesis	P02900	AICAR transformylase	THEMA|EnsemblGenome=TM_1249|UniProtKB=Q9X0X6	Bifunctional purine biosynthesis protein PurH	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	MACMU|Ensembl=ENSMMUG00000008336|UniProtKB=F6USE9	Uncharacterized protein	ISS			PTHR11699:SF233	ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IDA	91298951	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04543	MEKK1/4	MOUSE|MGI=MGI=1346875|UniProtKB=O08648	Mitogen-activated protein kinase kinase kinase 4	IDA	11730323	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	MACMU|Ensembl=ENSMMUG00000007387|UniProtKB=F7E0C1	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF12	RHODOPSIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CHICK|Ensembl=ENSGALG00000015358|UniProtKB=F1NM49	Uncharacterized protein	IC	10938134	PubMed	PTHR13140:SF575	MYOSIN-15
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00021	FGF signaling pathway	P00645	Rac	CAEEL|WormBase=WBGene00004287|UniProtKB=Q94124	Ras-related protein rac-2	IGI	4757952	gi	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00049	Parkinson disease	P01227	20S proteasome	BOVIN|Gene=PSMA6|UniProtKB=Q2YDE4	Proteasome subunit alpha type-6	ISS	12859888	PubMed	PTHR11599:SF11	PROTEASOME SUBUNIT ALPHA TYPE-6
P00029	Huntington disease	P00780	Microtubule	CAEEL|WormBase=WBGene00000248|UniProtKB=Q18817	Uncharacterized protein	IDA	9454836	PubMed	PTHR11588:SF120	SUBFAMILY NOT NAMED
P05915	Opioid proenkephalin pathway	P05994	G-protein	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00047	PDGF signaling pathway	P01168	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	ISS	10799299	PubMed	PTHR10048:SF14	PI-3 KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	MACMU|Gene=HTR2A|UniProtKB=P50128	5-hydroxytryptamine receptor 2A	ISS	11859080	PubMed	PTHR24247:SF30	5-HYDROXYTRYPTAMINE RECEPTOR 2A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	MACMU|Ensembl=ENSMMUG00000013047|UniProtKB=F7H808	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	PANTR|Ensembl=ENSPTRG00000013189|UniProtKB=H2QJV1	Uncharacterized protein	ISS	3768139	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P04392	P53 pathway feedback loops 1	G04686	p73	MOUSE|MGI=MGI=1336991|UniProtKB=Q9JJP2	Tumor protein p73	ISS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00911	B-Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	12068308	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00029	Huntington disease	P00780	Microtubule	DANRE|ZFIN=ZDB-GENE-040426-2879|UniProtKB=Q6IQJ2	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00006	Apoptosis signaling pathway	P00303	c-Jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	9166716	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	RAT|RGD=61800|UniProtKB=P14842	5-hydroxytryptamine receptor 2A	ISS	12181435	PubMed	PTHR24247:SF30	5-HYDROXYTRYPTAMINE RECEPTOR 2A
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05934	ELK1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	RCA	11279280	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06834	MAP3Ks	MOUSE|MGI=MGI=97509|UniProtKB=P63054	Purkinje cell protein 4	RCA			PTHR15359:SF7	PURKINJE CELL PROTEIN 4
P00036	Interleukin signaling pathway	P00996	STAT	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00019	Endothelin signaling pathway	P00570	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00061	PNMT	XENTR|Xenbase=XB-GENE-5748510|UniProtKB=F6YFA4	Uncharacterized protein (Fragment)	ISS			PTHR10867:SF5	NICOTINAMIDE N-METHYLTRANSFERASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00648	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	2837282	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	CAEEL|WormBase=WBGene00003239|UniProtKB=G5EBV3	Rac-like GTPase	ISS			PTHR24072:SF157	AT17867P
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00047	PDGF signaling pathway	P01154	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P04396	Vitamin D metabolism and pathway	P04603	1alpha-Hydroxylase	HUMAN|HGNC=2605|UniProtKB=Q02318	Sterol 26-hydroxylase, mitochondrial	IDA	11013342	PubMed	PTHR24291:SF6	STEROL 26-HYDROXYLASE, MITOCHONDRIAL
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02723	Adenine and hypoxanthine salvage pathway	P02807	Deoxyadenosine deaminase	SCHPO|PomBase=SPBC1198.02|UniProtKB=Q9P6I7	Adenine deaminase	ISS			PTHR43114:SF2	ADENINE DEAMINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	PANTR|Ensembl=ENSPTRG00000013428|UniProtKB=H2QK88	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF358	MYOSIN-7B
P04380	Cortocotropin releasing factor receptor signaling pathway	P04451	CRHR1	PANTR|Ensembl=ENSPTRG00000019043|UniProtKB=H2QUD3	Uncharacterized protein	ISS	11145609	PubMed	PTHR12011:SF274	CORTICOTROPIN-RELEASING FACTOR RECEPTOR 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	TETTS|EnsemblGenome=TTHERM_00630500|UniProtKB=Q241P0	Calmodulin 1	ISS	3885394	PubMed	PTHR23050:SF245	AT16150P-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	TAKRU|Ensembl=ENSTRUG00000017773|UniProtKB=H2V8M1	Uncharacterized protein (Fragment)	IDA	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P05915	Opioid proenkephalin pathway	P05994	G-protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04397	p53 pathway by glucose deprivation	P04639	AMPK	PANTR|Ensembl=ENSPTRG00000004895|UniProtKB=H2Q5U6	Protein kinase, AMP-activated, gamma 1 non-catalytic subunit	ISS			PTHR13780:SF38	5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1
P00005	Angiogenesis	P00184	Src	RAT|RGD=620795|UniProtKB=Q9WUD9	Proto-oncogene tyrosine-protein kinase Src	ISS	8054685	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00018	EGF receptor signaling pathway	P00540	MKK3,6	PANTR|Ensembl=ENSPTRG00000009588|UniProtKB=H2QZW5	Mitogen-activated protein kinase kinase 6	ISS	8622669	PubMed	PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00045	Notch signaling pathway	P01103	Next	MOUSE|MGI=MGI=97364|UniProtKB=O35516	Neurogenic locus notch homolog protein 2	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00021	FGF signaling pathway	P00642	MEK1-2	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IDA	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00005	Angiogenesis	P00243	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	15572354	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02749	Leucine biosynthesis	P03000	Branched chain amino acid aminotransferase	BACSU|EnsemblGenome=BSU02390|UniProtKB=O31461	Branched-chain-amino-acid transaminase 1	ISS			PTHR11825:SF44	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P00053	T cell activation	P01336	Jnk	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IGI	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00049	Parkinson disease	P01227	20S proteasome	SCHPO|PomBase=SPCC1442.06|UniProtKB=O94579	Probable proteasome subunit alpha type-2	TAS	12859888	PubMed	PTHR11599:SF16	PROTEASOME SUBUNIT ALPHA TYPE-2
P00036	Interleukin signaling pathway	P00990	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	BOVIN|Gene=STAT3|UniProtKB=P61635	Signal transducer and activator of transcription 3	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00059	p53 pathway	P01486	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	TAS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PHYPA|Gene=PHYPADRAFT_226658|UniProtKB=A9TYG3	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00029	Huntington disease	P00807	Actin	DANRE|ZFIN=ZDB-GENE-030131-55|UniProtKB=Q6XNL8	Actin	IDA	11889126	PubMed	PTHR11937:SF263	ACTIN
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00009	Axon guidance mediated by netrin	P00359	NFAT	BOVIN|Ensembl=ENSBTAG00000004368|UniProtKB=F1MSU2	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P05731	GABA-B receptor II signaling	P05755	Gbeta	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	MOUSE|MGI=MGI=106217|UniProtKB=Q61290	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	8386525	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	XENTR|Xenbase=XB-GENE-967585|UniProtKB=Q28BZ0	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P06664	Gonadotropin-releasing hormone receptor pathway	P06850	PKCs(3)	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	RCA	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00021	FGF signaling pathway	P00641	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	IC	10074940	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00470	F-actin	CAEEL|WormBase=WBGene00000065|UniProtKB=P0DM42	Actin-3	IC	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00059	p53 pathway	P04633	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00205	GAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	11847220	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05731	GABA-B receptor II signaling	P05752	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	RCA	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00021	FGF signaling pathway	P00641	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	MOUSE|MGI=MGI=97364|UniProtKB=O35516	Neurogenic locus notch homolog protein 2	IDA	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	CHICK|Gene=BMPR1B|UniProtKB=Q05438	Bone morphogenetic protein receptor type-1B	TAS	10683140	PubMed	PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MOUSE|MGI=MGI=1354734|UniProtKB=Q9DC04	Regulator of G-protein signaling 3	IDA	8756726	PubMed	PTHR10845:SF4	REGULATOR OF G-PROTEIN SIGNALING 3
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00029	Huntington disease	P00774	Dynein complex	CAEEL|WormBase=WBGene00001005|UniProtKB=Q22799	Dynein light chain 1, cytoplasmic	IPI	9454836	PubMed	PTHR11886:SF35	DYNEIN LIGHT CHAIN 2, CYTOPLASMIC
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00840	GPRK	BOVIN|Ensembl=ENSBTAG00000043994|UniProtKB=E1BP29	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00053	T cell activation	P01294	NFAT	MOUSE|MGI=MGI=103296|UniProtKB=P97305	Nuclear factor of activated T-cells, cytoplasmic 3	IGI	9462517	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	TAS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02761	Pantothenate biosynthesis	P03067	3-methyl-2-oxobutanoate hydroxymethyltransferase	GLOVI|EnsemblGenome=BAC88703|UniProtKB=Q7NMK3	3-methyl-2-oxobutanoate hydroxymethyltransferase	ISS			PTHR20881:SF0	3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE
P00059	p53 pathway	P04633	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00020	FAS signaling pathway	P00615	JNK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00021	FGF signaling pathway	P00644	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00049	Parkinson disease	P01238	14-3-3	MOUSE|MGI=MGI=894689|UniProtKB=P62259	14-3-3 protein epsilon	ISS	9450960	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P06959	CCKR signaling map	P07072	CSK	HUMAN|HGNC=2444|UniProtKB=P41240	Tyrosine-protein kinase CSK	RCA	10400698	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P02779	Thiamin biosynthesis	P03173	Thiamin phosphate synthase	GLOVI|EnsemblGenome=BAC88344|UniProtKB=Q7NNK8	Thiamine-phosphate synthase	ISS			PTHR20857:SF15	THIAMINE BIOSYNTHETIC BIFUNCTIONAL ENZYME
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P02748	Isoleucine biosynthesis	P02995	Threonine dehydratase	CAEEL|WormBase=WBGene00011353|UniProtKB=Q93968	Uncharacterized protein	ISS			PTHR43050:SF1	SERINE RACEMASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00029	Huntington disease	P00780	Microtubule	STRPU|EnsemblGenome=SPU_013273|UniProtKB=W4YBZ7	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P02749	Leucine biosynthesis	P03002	Isopropylmalate isomerase	STRCO|EnsemblGenome=CAA20001|UniProtKB=O86534	3-isopropylmalate dehydratase large subunit	ISS			PTHR43822:SF2	HOMOACONITASE, MITOCHONDRIAL
P00034	Integrin signalling pathway	P00912	Arp2/3	ORNAN|Ensembl=ENSOANG00000000999|UniProtKB=F6WN02	Actin-related protein 2/3 complex subunit 5	ISS	9230079	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00029	Huntington disease	P00797	p53	DANRE|ZFIN=ZDB-GENE-030814-2|UniProtKB=B0S576	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00021	FGF signaling pathway	P00623	FGF	HUMAN|HGNC=3685|UniProtKB=P21781	Fibroblast growth factor 7	ISS			PTHR11486:SF20	FIBROBLAST GROWTH FACTOR 7
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00644	p38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	IGI	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	IDA	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04393	Ras Pathway	P04578	Rho	HUMAN|HGNC=667|UniProtKB=P61586	Transforming protein RhoA	ISS	12039949	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	DANRE|ZFIN=ZDB-GENE-030729-1|UniProtKB=B3DGN0	Opioid receptor, kappa 1	IDA	11259487	PubMed	PTHR24229:SF1	KAPPA-TYPE OPIOID RECEPTOR
P00057	Wnt signaling pathway	P01435	SWI/SNF	CAEEL|WormBase=WBGene00011111|UniProtKB=Q21831	SNF chromatin remodeling Complex component	IDA	11532957	PubMed	PTHR10019:SF5	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY B MEMBER 1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	IC	9199552	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	RAT|RGD=2739|UniProtKB=Q00961	Glutamate receptor ionotropic, NMDA 2C	IC	11554549	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02788	Xanthine and guanine salvage pathway	P03245	Guanine phosphoribosyl transferase	FUSNN|EnsemblGenome=FN0288|UniProtKB=Q8RGK5	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00047	PDGF signaling pathway	P01162	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	BOVIN|Ensembl=ENSBTAG00000003054|UniProtKB=F1MC23	Tyrosine-protein kinase receptor	ISS	11182407	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IGI	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	ORNAN|Ensembl=ENSOANG00000010302|UniProtKB=F6TDQ6	Uncharacterized protein	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	DROME|FlyBase=FBgn0087012|UniProtKB=Q8IPN2	5-hydroxytryptamine (Serotonin) receptor 2A, isoform B	IDA	8143856	PubMed	PTHR24247:SF125	5-HYDROXYTRYPTAMINE  SEROTONIN  RECEPTOR 2A, ISOFORM B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PLAF7|EnsemblGenome=PF11_0147|UniProtKB=Q7KQK7	Mitogen-activated protein kinase	IDA	11559502	gi	PTHR24055:SF189	SUBFAMILY NOT NAMED
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-040426-1712|UniProtKB=Q6PBY0	Guanine nucleotide binding protein (G protein), beta 5	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00019	Endothelin signaling pathway	P00589	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	STRPU|EnsemblGenome=SPU_018419|UniProtKB=W4YRI6	Uncharacterized protein	ISS	97210759	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00058	mRNA splicing	P01476	U4	MOUSE|MGI=MGI=1918017|UniProtKB=Q922U1	U4/U6 small nuclear ribonucleoprotein Prp3	ISS	9328476	PubMed	PTHR14212:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MACMU|Ensembl=ENSMMUG00000012672|UniProtKB=F7E305	Uncharacterized protein	ISS			PTHR13140:SF276	UNCONVENTIONAL MYOSIN-X
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00010	B cell activation	P00381	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	IGI	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	HUMAN|HGNC=1392|UniProtKB=Q15878	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	14507926	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	XENTR|Xenbase=XB-GENE-967585|UniProtKB=Q28BZ0	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00261	Bok	MOUSE|MGI=MGI=1858494|UniProtKB=O35425	Bcl-2-related ovarian killer protein	ISS	9356461	PubMed	PTHR11256:SF48	BCL-2-RELATED OVARIAN KILLER PROTEIN
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01161	Raf	XENTR|Xenbase=XB-GENE-1014202|UniProtKB=F6V946	Uncharacterized protein (Fragment)	ISS	3043188	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	BOVIN|Ensembl=ENSBTAG00000015278|UniProtKB=Q5E963	Actin-related protein 2/3 complex subunit 5-like protein	ISS	12932731	PubMed	PTHR12644:SF2	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5-LIKE PROTEIN
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	PANTR|Ensembl=ENSPTRG00000017238|UniProtKB=H2QRH7	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	PANTR|Ensembl=ENSPTRG00000020099|UniProtKB=H2QVX6	Uncharacterized protein	ISS	Q90635	SPACC	PTHR11647:SF56	DIHYDROPYRIMIDINASE-RELATED PROTEIN 2
P00006	Apoptosis signaling pathway	P00317	Fos	PANTR|Ensembl=ENSPTRG00000006553|UniProtKB=A5A6H0	C-fos	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00047	PDGF signaling pathway	P01162	MEK	CAEBR|Gene=CBG04190|UniProtKB=A8WWD7	Protein CBR-MEK-2	ISS	176872	OMIM	PTHR24361:SF629	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IGI	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PHANO|EnsemblGenome=SNOG_01139|UniProtKB=H2KNE6	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CHICK|Ensembl=ENSGALG00000011248|UniProtKB=F1P354	Phosphoinositide phospholipase C	ISS			PTHR10336:SF84	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2
P00021	FGF signaling pathway	P00630	RKIP	DROME|FlyBase=FBgn0037432|UniProtKB=Q9VI08	GH28351p	ISS			PTHR11362:SF28	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00056	VEGF signaling pathway	P01419	Ets	XENTR|Xenbase=XB-GENE-6465484|UniProtKB=B3DM35	LOC100170599 protein	ISS	2205841	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01092	delta	XENTR|Xenbase=XB-GENE-989975|UniProtKB=F6WX27	Uncharacterized protein (Fragment)	ISS	85203892	PubMed	PTHR18945:SF61	ACETYLCHOLINE RECEPTOR SUBUNIT DELTA
P00060	Ubiquitin proteasome pathway	P01491	E2	TAKRU|Ensembl=ENSTRUG00000006440|UniProtKB=H2STM0	Uncharacterized protein	ISS			PTHR24068:SF120	UBIQUITIN-CONJUGATING ENZYME E2D 2  UBC4/5 HOMOLOG, YEAST
P02776	Serine glycine biosynthesis	P03159	Phosphoserine phosphatase	SCHPO|PomBase=SPBC3H7.07c|UniProtKB=O74382	Probable phosphoserine phosphatase	ISS			PTHR43344:SF2	PHOSPHOSERINE PHOSPHATASE
P00059	p53 pathway	G04694	p110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	CANLF|Ensembl=ENSCAFG00000004381|UniProtKB=J9JH96	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00018	EGF receptor signaling pathway	P00558	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00052	TGF-beta signaling pathway	P01292	RSmads	MACMU|Ensembl=ENSMMUG00000000340|UniProtKB=F6YMS3	Mothers against decapentaplegic homolog	ISS	12736218	PubMed	PTHR13703:SF36	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02731	Biotin biosynthesis	P02859	Dethiobiotin synthase	RHOBA|EnsemblGenome=RB5694|UniProtKB=Q7URG0	ATP-dependent dethiobiotin synthetase BioD	ISS			PTHR43210:SF2	DETHIOBIOTIN SYNTHETASE
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	MACMU|Ensembl=ENSMMUG00000012488|UniProtKB=F7HB04	10-formyltetrahydrofolate dehydrogenase	ISS			PTHR11699:SF120	CYTOSOLIC 10-FORMYLTETRAHYDROFOLATE DEHYDROGENASE
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00011	Blood coagulation	P00429	PN2	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	ISS	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00049	Parkinson disease	P01226	CDCrel-1	MOUSE|MGI=MGI=1858916|UniProtKB=P42209	Septin-1	IDA			PTHR18884:SF6	SEPTIN-1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00006	Apoptosis signaling pathway	P00274	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	PANTR|Ensembl=ENSPTRG00000005015|UniProtKB=H2Q624	Anti-Muellerian hormone type-2 receptor	ISS	9395284	PubMed	PTHR23255:SF49	ANTI-MUELLERIAN HORMONE TYPE-2 RECEPTOR
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00906	Rap1	HUMAN|HGNC=9855|UniProtKB=P62834	Ras-related protein Rap-1A	ISS	10476970	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00005	Angiogenesis	P00243	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00019	Endothelin signaling pathway	P00591	PLCbeta	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IGI	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00018	EGF receptor signaling pathway	P00554	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	7680960	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P02741	Flavin biosynthesis	P02934	Riboflavin kinase	GLOVI|Gene=BAC88158|UniProtKB=Q7NP41	Riboflavin biosynthesis protein	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P00019	Endothelin signaling pathway	P00566	ERK	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00056	VEGF signaling pathway	P01413	PI3K	CAEEL|WormBase=WBGene00009552|UniProtKB=G5EDY0	Phosphatidylinositol 3-kinase piki-1	ISS	7937853	PubMed	PTHR10048:SF64	LD28067P
P00047	PDGF signaling pathway	P01171	PLCgamma	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04451	CRHR1	RAT|RGD=61276|UniProtKB=P35353	Corticotropin-releasing factor receptor 1	ISS	11145609	PubMed	PTHR12011:SF175	CORTICOTROPIN-RELEASING FACTOR RECEPTOR 1
P00006	Apoptosis signaling pathway	P00269	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01239	Cul-1	CANLF|Ensembl=ENSCAFG00000003440|UniProtKB=E2R1V2	Uncharacterized protein	ISS	12628165	PubMed	PTHR11932:SF81	CULLIN-1
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=97614|UniProtKB=Q8R3B1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	7822322	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00048	PI3 kinase pathway	P01192	p110	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00807	Actin	DROME|FlyBase=FBgn0000044|UniProtKB=P53501	Actin-57B	IDA	11889126	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00047	PDGF signaling pathway	P01173	STAT	CANLF|Ensembl=ENSCAFG00000015346|UniProtKB=E2RE22	Signal transducer and activator of transcription	ISS	14662325	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CHICK|Ensembl=ENSGALG00000000678|UniProtKB=Q9I8K7	Cbp/p300-interacting transactivator 3	TAS	9865691	PubMed	PTHR17045:SF5	CBP/P300-INTERACTING TRANSACTIVATOR 4
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MOUSE|MGI=MGI=103307|UniProtKB=P54285	Voltage-dependent L-type calcium channel subunit beta-3	IC			PTHR11824:SF8	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-3
P04397	p53 pathway by glucose deprivation	P04645	TSC1	MACMU|Ensembl=ENSMMUG00000009918|UniProtKB=F6Y6G0	Hamartin isoform 1	ISS	12167664	PubMed	PTHR15154:SF2	HAMARTIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	MOUSE|MGI=MGI=894315|UniProtKB=Q99JI6	Ras-related protein Rap-1b	ISS	1904317	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	7492337	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P02736	Coenzyme A biosynthesis	P02885	Pantothenate kinase	EMENI|EnsemblGenome=CADANIAG00005593|UniProtKB=G5EAY3	Uncharacterized protein	ISS			PTHR12280:SF20	PANTOTHENATE KINASE 4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000031262|UniProtKB=H2RAB4	Uncharacterized protein	ISS			PTHR43893:SF8	D 1B  DOPAMINE RECEPTOR
P00048	PI3 kinase pathway	P01192	p110	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00126	Fe65	MOUSE|MGI=MGI=108405|UniProtKB=Q9DBR4	Amyloid beta A4 precursor protein-binding family B member 2	ISS			PTHR14058:SF11	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 2
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MOUSE|MGI=MGI=88398|UniProtKB=Q9ERZ3	Muscarinic acetylcholine receptor M3	TAS	11166329	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BRAFL|Gene=BRAFLDRAFT_220697|UniProtKB=C3ZSF0	Putative uncharacterized protein	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P02744	Fructose galactose metabolism	P02964	Hexose 1-P uridyltransferase	CANLF|Ensembl=ENSCAFG00000001946|UniProtKB=E2RB65	Galactose-1-phosphate uridylyltransferase	ISS	1610789	PubMed	PTHR11943:SF1	GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE
P00005	Angiogenesis	P00211	GSK3beta	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	DAPPU|EnsemblGenome=DAPPUDRAFT_308117|UniProtKB=E9H6I3	Putative uncharacterized protein	ISS			PTHR23073:SF31	26S PROTEASE REGULATORY SUBUNIT 10B
P00036	Interleukin signaling pathway	P00970	Interleukin	PANTR|Ensembl=ENSPTRG00000016419|UniProtKB=H2QQ45	Interleukin	ISS	11081504	PubMed	PTHR14356:SF2	INTERLEUKIN-21
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00047	PDGF signaling pathway	P01143	ERK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00577	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01439	C-terminal Binding Protein	RAT|RGD=2441|UniProtKB=Q9Z2F5	C-terminal-binding protein 1	IDA	10375506	PubMed	PTHR10996:SF128	C-TERMINAL-BINDING PROTEIN 1
P00046	Oxidative stress response	P01135	p38	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	TAS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00005	Angiogenesis	P00190	RasGAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	11847220	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00010	B cell activation	P00391	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01438	PP2A	TAKRU|Ensembl=ENSTRUG00000008018|UniProtKB=H2T5N4	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00633	Ras	MONDO|Ensembl=ENSMODG00000025248|UniProtKB=F7F5X1	Uncharacterized protein	ISS	99084794	PubMed	PTHR24070:SF186	GTPASE KRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MOUSE|MGI=MGI=1341110|UniProtKB=P97490	Adenylate cyclase type 8	IDA	8163524	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00029	Huntington disease	P00787	MAPKK4	CHICK|Ensembl=ENSGALG00000001001|UniProtKB=F1P3T1	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04396	Vitamin D metabolism and pathway	P04603	1alpha-Hydroxylase	MACMU|Ensembl=ENSMMUG00000022144|UniProtKB=F7H3A6	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	ISS	10232681	PubMed	PTHR24291:SF3	25-HYDROXYVITAMIN D-1 ALPHA HYDROXYLASE, MITOCHONDRIAL
P02727	Androgen/estrogene/progesterone biosynthesis	P02829	Cholesterol acyltransferase	HUMAN|HGNC=11177|UniProtKB=P35610	Sterol O-acyltransferase 1	ISS	11948213	PubMed	PTHR10408:SF6	STEROL O-ACYLTRANSFERASE 1
P00059	p53 pathway	G04694	p110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04609	PI3K	XENTR|Xenbase=XB-GENE-6085226|UniProtKB=F6ZM84	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00047	PDGF signaling pathway	P01168	PI3K	XENTR|Xenbase=XB-GENE-6067221|UniProtKB=F6Z0J4	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00925	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IDA	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	DANRE|ZFIN=ZDB-GENE-051202-1|UniProtKB=E7F101	Uncharacterized protein	ISS	11319238	PubMed	PTHR44391:SF2	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PRIPA|Gene=PPA17339|UniProtKB=H3F5B4	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF352	ACTIN
P00005	Angiogenesis	P00211	GSK3beta	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IDA	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	IDA	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00021	FGF signaling pathway	P00635	FRS2	HUMAN|HGNC=16971|UniProtKB=Q8WU20	Fibroblast growth factor receptor substrate 2	IGI	12571252	PubMed	PTHR21258:SF40	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=7593|UniProtKB=Q9HD67	Unconventional myosin-X	IC			PTHR13140:SF276	UNCONVENTIONAL MYOSIN-X
P00029	Huntington disease	P00768	Apaf-1	MACMU|Ensembl=ENSMMUG00000022404|UniProtKB=F6U0K7	Apoptotic protease-activating factor 1	ISS	14526190	PubMed	PTHR22845:SF5	APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
P00005	Angiogenesis	P00223	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04397	p53 pathway by glucose deprivation	P04641	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05957	K+ channel	PANTR|Ensembl=ENSPTRG00000020614|UniProtKB=H2QWR7	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00021	FGF signaling pathway	P00628	JNK1-3	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS			PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2344|UniProtKB=P08485	Muscarinic acetylcholine receptor M4	IDA	10069496	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00049	Parkinson disease	P01219	SAPK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	NAS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00627	ERK1-2	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	IGI	12787066	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00021	FGF signaling pathway	P00647	SHP2	BOVIN|Ensembl=ENSBTAG00000002048|UniProtKB=F1N339	Tyrosine-protein phosphatase non-receptor type	ISS	14525967	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00001	Adrenaline and noradrenaline biosynthesis	P00067	MAO	PANTR|Ensembl=ENSPTRG00000021816|UniProtKB=H2QYH5	Amine oxidase [flavin-containing]	ISS	8602220	PubMed	PTHR43563:SF3	AMINE OXIDASE  FLAVIN-CONTAINING  A
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MACMU|Ensembl=ENSMMUG00000016751|UniProtKB=F7AIB6	Mitogen-activated protein kinase kinase kinase 3 isoform 1	ISS	11730323	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P02752	Mannose metabolism	P03018	Mannose 1-P guanylyl transferase	BOVIN|Gene=GMPPB|UniProtKB=Q2YDJ9	Mannose-1-phosphate guanyltransferase beta	ISS	11082198	PubMed	PTHR22572:SF15	MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE BETA
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00759	PDEalphabeta	MACMU|Ensembl=ENSMMUG00000004752|UniProtKB=F6SMY5	Phosphodiesterase	ISS	P27664	SPACC	PTHR11347:SF115	ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	MOUSE|MGI=MGI=1353452|UniProtKB=P47740	Fatty aldehyde dehydrogenase	IC	14724059	PubMed	PTHR43570:SF9	FATTY ALDEHYDE DEHYDROGENASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IDA	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00029	Huntington disease	P00788	Calpain	MACMU|Ensembl=ENSMMUG00000015308|UniProtKB=F6Q6Z5	Uncharacterized protein	ISS	11675509	PubMed	PTHR10183:SF381	CALPAIN-6
P00045	Notch signaling pathway	P01120	NIcs	RAT|RGD=3188|UniProtKB=Q9QW30	Neurogenic locus notch homolog protein 2	IEP	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P02736	Coenzyme A biosynthesis	P02883	Pantothenoylcysteine decarboxylase	GLOVI|Gene=BAC89489|UniProtKB=Q7NKD0	Glr1548 protein	ISS			PTHR14359:SF6	PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	PANTR|Ensembl=ENSPTRG00000024086|UniProtKB=H2R1M3	Uncharacterized protein	ISS	12063255	PubMed	PTHR24248:SF3	BETA-3 ADRENERGIC RECEPTOR
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	DANRE|ZFIN=ZDB-GENE-040718-93|UniProtKB=Q6DGZ5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00011	Blood coagulation	P00407	PZ	PANTR|Ensembl=ENSPTRG00000006051|UniProtKB=H2Q7U0	Uncharacterized protein	ISS			PTHR24278:SF20	VITAMIN K-DEPENDENT PROTEIN Z
P00047	PDGF signaling pathway	P01153	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00021	FGF signaling pathway	P00645	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	IPI	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	CHICK|Gene=AXIN1|UniProtKB=O42400	Axin-1	IEP	12356903	PubMed	PTHR10845:SF11	AXIN-1
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00057	Wnt signaling pathway	P01448	CBP	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00034	Integrin signalling pathway	P00940	Src	PANTR|Ensembl=ENSPTRG00000013474|UniProtKB=H2QKB4	Tyrosine-protein kinase	ISS	8054685	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00045	Notch signaling pathway	P01103	Next	RAT|RGD=2938|UniProtKB=P97607	Protein jagged-2 (Fragment)	IDA	12826675	PubMed	PTHR44097:SF1	PROTEIN JAGGED-2
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	TAKRU|Ensembl=ENSTRUG00000011169|UniProtKB=H2TU36	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00011	Blood coagulation	P00444	FIX	CANLF|Gene=F9|UniProtKB=P19540	Coagulation factor IX	ISS	14270099	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P00059	p53 pathway	G01566	TSP1	BOVIN|Gene=THBS1|UniProtKB=Q28178	Thrombospondin-1	IGI	7521539	PubMed	PTHR10199:SF78	THROMBOSPONDIN-1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	HUMAN|HGNC=144|UniProtKB=P63261	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IC	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	XENTR|Xenbase=XB-GENE-5923225|UniProtKB=F6RVZ6	Glutamine synthetase (Fragment)	ISS			PTHR20852:SF43	GLUTAMINE SYNTHETASE
P00018	EGF receptor signaling pathway	P00562	p38	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	8925912	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00005	Angiogenesis	P00186	FGFR-1	PANTR|Ensembl=ENSPTRG00000020176|UniProtKB=H2R210	Fibroblast growth factor receptor	ISS	9763444	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	SCHPO|PomBase=SPCC825.03c|UniProtKB=Q9USH7	Syntaxin-like protein psy1	IC			PTHR19957:SF41	SYNTAXIN-1A
P00029	Huntington disease	P00796	Kainate receptor	CANLF|Ensembl=ENSCAFG00000003333|UniProtKB=F1PWT6	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P06664	Gonadotropin-releasing hormone receptor pathway	P06834	MAP3Ks	MOUSE|MGI=MGI=1346873|UniProtKB=Q61083	Mitogen-activated protein kinase kinase kinase 2	RCA	11730323	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	METAC|EnsemblGenome=MA_0610|UniProtKB=Q8TT29	Transcription initiation factor IIB	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	ARATH|TAIR=AT3G17390|UniProtKB=Q9LUT2	S-adenosylmethionine synthase 4	ISS			PTHR11964:SF35	S-ADENOSYLMETHIONINE SYNTHASE 4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02738	De novo purine biosynthesis	P02892	5-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase	PYRAE|EnsemblGenome=PAE0972|UniProtKB=Q8ZY28	Adenylosuccinate lyase (PurB)	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P04398	p53 pathway feedback loops 2	P04651	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P00059	p53 pathway	P04623	CBP	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00640	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00005	Angiogenesis	P00188	Ets	MACMU|Ensembl=ENSMMUG00000020706|UniProtKB=F6PU72	Uncharacterized protein	ISS	9157999	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	METAC|EnsemblGenome=MA_1524|UniProtKB=Q8TQL6	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P02723	Adenine and hypoxanthine salvage pathway	P02811	Adenosine deaminase	STRCO|EnsemblGenome=CAA19890|UniProtKB=O86737	Aminodeoxyfutalosine deaminase	ISS			PTHR43114:SF3	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01179	PKB	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00019	Endothelin signaling pathway	P00591	PLCbeta	DROME|FlyBase=FBgn0004611|UniProtKB=P25455	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00243	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04544	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	15210125	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	9332390	PubMed	PTHR10202:SF13	PRESENILIN-2
P00048	PI3 kinase pathway	P01182	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01423	p38MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00029	Huntington disease	P00811	Arp2/3 complex	CAEEL|WormBase=WBGene00000201|UniProtKB=Q9U1R7	ARp2/3 compleX component	TAS	12963527	gi	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05918	p38 MAPK pathway	P06031	p38alpha	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	RCA	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04384	Gamma-aminobutyric acid synthesis	P04482	Glutamate decarboxylase	XENTR|Xenbase=XB-GENE-1011699|UniProtKB=F6T9C2	Uncharacterized protein	ISS	2247446	PubMed	PTHR11999:SF57	GLUTAMATE DECARBOXYLASE 1
P00048	PI3 kinase pathway	P01177	P110ACT	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	8787761	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	MACMU|Ensembl=ENSMMUG00000030786|UniProtKB=F7G075	Uncharacterized protein	ISS	11055438	PubMed	PTHR10117:SF25	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 4
P00057	Wnt signaling pathway	P01438	PP2A	MACMU|Ensembl=ENSMMUG00000020819|UniProtKB=F7HSM1	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04398	p53 pathway feedback loops 2	P04651	Ras	MACMU|Ensembl=ENSMMUG00000015381|UniProtKB=F6SFG7	Uncharacterized protein	ISS	6287573	PubMed	PTHR24070:SF186	GTPASE KRAS
P00034	Integrin signalling pathway	P00907	ERK	PANTR|Ensembl=ENSPTRG00000016891|UniProtKB=H2R5K3	Uncharacterized protein	ISS			PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00005	Angiogenesis	P00236	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS			PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00010	B cell activation	P00402	Jnk	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00010	B cell activation	P00391	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CHICK|Ensembl=ENSGALG00000009640|UniProtKB=F1P0I0	Muscarinic acetylcholine receptor	IDA			PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00048	PI3 kinase pathway	P01199	Galpha	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00053	T cell activation	P01320	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00030	Hypoxia response via HIF activation	P00823	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	96009592	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00012	Cadherin signaling pathway	P00470	F-actin	TAKRU|Ensembl=ENSTRUG00000004787|UniProtKB=P53480	Actin, alpha cardiac	IC	10974003	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00034	Integrin signalling pathway	P00944	Actin	MOUSE|MGI=MGI=87904|UniProtKB=P60710	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00059	p53 pathway	P04610	Cyclin E	MACMU|Ensembl=ENSMMUG00000020668|UniProtKB=F7BEI4	Uncharacterized protein	ISS	12628165	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	DANRE|Ensembl=ENSDARG00000070511|UniProtKB=E7F5R2	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF282	GLUTAMATE RECEPTOR-RELATED
P00036	Interleukin signaling pathway	P00976	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02730	Asparagine and aspartate biosynthesis	P02853	Asparagine synthetase	STRCO|Gene=CAB58327|UniProtKB=Q9RJK2	Putative asparagine synthetase	ISS			PTHR43284:SF2	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IDA	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00046	Oxidative stress response	P01135	p38	CAEBR|Gene=CBG01555|UniProtKB=A8WRD7	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00029	Huntington disease	P00774	Dynein complex	TAKRU|Ensembl=ENSTRUG00000012516|UniProtKB=H2U434	Uncharacterized protein (Fragment)	ISS	9454836	PubMed	PTHR10676:SF314	CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1
P00010	B cell activation	P00373	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=11439|UniProtKB=Q12846	Syntaxin-4	ISS			PTHR19957:SF97	SYNTAXIN-4
P04397	p53 pathway by glucose deprivation	P04641	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=97614|UniProtKB=Q8R3B1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	15611108	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00047	PDGF signaling pathway	P01171	PLCgamma	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00047	PDGF signaling pathway	P01154	Ras	MONDO|Ensembl=ENSMODG00000025248|UniProtKB=F7F5X1	Uncharacterized protein	ISS	3023884	PubMed	PTHR24070:SF186	GTPASE KRAS
P00029	Huntington disease	P00777	CBP	CAEEL|WormBase=WBGene00009595|UniProtKB=Q7JMS5	Uncharacterized protein	IDA	10769018	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	HUMAN|HGNC=1389|UniProtKB=Q00975	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	11976940	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MACMU|Ensembl=ENSMMUG00000015799|UniProtKB=F7APE4	Metalloendopeptidase	ISS	9759503	PubMed	PTHR43978:SF4	TOLLOID-LIKE PROTEIN 1
P00057	Wnt signaling pathway	P01451	Galpha	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IDA	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01177	P110ACT	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00391	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	RAT|RGD=621802|UniProtKB=P11730	Calcium/calmodulin-dependent protein kinase type II subunit gamma	ISS	12888804	PubMed	PTHR43940:SF7	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT GAMMA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00049	Parkinson disease	P01233	Elk-1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	IDA	11279280	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00052	TGF-beta signaling pathway	P01275	P38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	TAS	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000002647|UniProtKB=F7DIB7	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00056	VEGF signaling pathway	P01413	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	12660731	PubMed	PTHR10048:SF14	PI-3 KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CANLF|Ensembl=ENSCAFG00000018564|UniProtKB=E2RHU1	Uncharacterized protein	ISS	20112749	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P02741	Flavin biosynthesis	P02934	Riboflavin kinase	DROME|FlyBase=FBgn0014930|UniProtKB=O76206	Putative riboflavin kinase	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P00059	p53 pathway	P04631	P21	MACMU|Ensembl=ENSMMUG00000003210|UniProtKB=F7EEK4	Cyclin-dependent kinase inhibitor 1	ISS			PTHR10265:SF16	CYCLIN-DEPENDENT KINASE INHIBITOR 1
P00057	Wnt signaling pathway	P01438	PP2A	PANTR|Ensembl=ENSPTRG00000003853|UniProtKB=H2Q411	Protein phosphatase 2, regulatory subunit B', beta	ISS	11531413	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00924	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01207	PLD2	HUMAN|HGNC=9068|UniProtKB=O14939	Phospholipase D2	IDA	12615079	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00019	Endothelin signaling pathway	P00572	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	ORNAN|Ensembl=ENSOANG00000010302|UniProtKB=F6TDQ6	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00034	Integrin signalling pathway	P00931	Integrin beta	MOUSE|MGI=MGI=96612|UniProtKB=O54890	Integrin beta-3	IDA	7949057	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	RAT|RGD=61916|UniProtKB=Q08463	Frizzled-1	TAS	8717036	PubMed	PTHR11309:SF81	FRIZZLED-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00006	Apoptosis signaling pathway	P00260	AKT	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	ISS	12719720	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00046	Oxidative stress response	P01134	cPLA2	CANLF|Ensembl=ENSCAFG00000013778|UniProtKB=F6UQ33	Phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00029	Huntington disease	P00780	Microtubule	IXOSC|EnsemblGenome=ISCW017133|UniProtKB=B7PA92	Beta tubulin	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05730	Endogenous cannabinoid signaling	P05746	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00034	Integrin signalling pathway	P00928	alpha actinin	HUMAN|HGNC=166|UniProtKB=O43707	Alpha-actinin-4	IPI	2116421	PubMed	PTHR43947:SF7	ALPHA-ACTININ-4
P00054	Toll receptor signaling pathway	P01358	ERK1	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02771	Pyrimidine Metabolism	P03127	Beta-Ureidopropionase	MACMU|Ensembl=ENSMMUG00000000262|UniProtKB=F6X9A2	Uncharacterized protein	ISS	10542323	PubMed	PTHR43674:SF2	BETA-UREIDOPROPIONASE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00057	Wnt signaling pathway	P01435	SWI/SNF	DROME|FlyBase=FBgn0011715|UniProtKB=Q24090	GH08712p	IDA	11532957	PubMed	PTHR10019:SF5	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY B MEMBER 1
P00060	Ubiquitin proteasome pathway	P01490	E3	MOUSE|MGI=MGI=97297|UniProtKB=P46935	E3 ubiquitin-protein ligase NEDD4	ISS			PTHR11254:SF282	E3 UBIQUITIN-PROTEIN LIGASE NEDD4
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00005	Angiogenesis	P00211	GSK3beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	SCHMA|EnsemblGenome=Smp_046600|UniProtKB=G4VLW2	Putative actin-1	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95814|UniProtKB=Q60934	Glutamate receptor ionotropic, kainate 1	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	NEUCR|EnsemblGenome=EFNCRG00000004240|UniProtKB=Q01386	cAMP-dependent protein kinase regulatory subunit	IC	91298951	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DANRE|ZFIN=ZDB-GENE-000329-3|UniProtKB=Q7ZVF9	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=1562864|UniProtKB=D4A497	Protein Pcdh11x	ISS	8120095	PubMed	PTHR43912:SF1	PROTOCADHERIN-11 X-LINKED-RELATED
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CAEEL|WormBase=WBGene00000063|UniProtKB=P0DM41	Actin-1	IDA	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00048	PI3 kinase pathway	P01177	P110ACT	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	RAT|RGD=3425|UniProtKB=P97887	Presenilin-1	TAS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P05734	Synaptic vesicle trafficking	P05776	RIM1alpha/2alpha	RAT|RGD=620001|UniProtKB=Q9JIS1	Regulating synaptic membrane exocytosis protein 2	RCA			PTHR12157:SF15	REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN 2
P02776	Serine glycine biosynthesis	P03160	Phosphoglycerate dehydrogenase	ECOLI|EcoGene=EG10944|UniProtKB=P0A9T0	D-3-phosphoglycerate dehydrogenase	ISS			PTHR10996:SF165	D-3-PHOSPHOGLYCERATE DEHYDROGENASE 1-RELATED
P04398	p53 pathway feedback loops 2	P04661	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00049	Parkinson disease	P01219	SAPK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	NAS	11707292	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00053	T cell activation	P01312	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02749	Leucine biosynthesis	P03000	Branched chain amino acid aminotransferase	RAT|RGD=2195|UniProtKB=P54690	Branched-chain-amino-acid aminotransferase, cytosolic	ISS			PTHR11825:SF51	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, CYTOSOLIC
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01318	PKC-theta	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	MACMU|Ensembl=ENSMMUG00000023736|UniProtKB=F7G778	Uncharacterized protein	ISS	18005395	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	ANOGA|EnsemblGenome=AGAP003718|UniProtKB=Q7QG26	AGAP003718-PA	IDA	8756726	PubMed	PTHR10845:SF151	LP21163P
P00020	FAS signaling pathway	P00601	c-Jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00053	T cell activation	P01300	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	PANTR|Ensembl=ENSPTRG00000003839|UniProtKB=H2Q401	Ribosomal protein S6 kinase	ISS	9792677	PubMed	PTHR24351:SF41	RIBOSOMAL PROTEIN S6 KINASE ALPHA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DROME|FlyBase=FBgn0015765|UniProtKB=O62618	Mitogen-activated protein kinase 14A	IDA	11274345	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00036	Interleukin signaling pathway	P00977	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00049	Parkinson disease	P01238	14-3-3	HUMAN|HGNC=12852|UniProtKB=P61981	14-3-3 protein gamma	IDA	99360936	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01407	Erk	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	10395542	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	IC	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00021	FGF signaling pathway	P00648	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00005	Angiogenesis	P00242	TCF	HUMAN|HGNC=11639|UniProtKB=P36402	Transcription factor 7	RCA			PTHR10373:SF33	TRANSCRIPTION FACTOR 7
P04397	p53 pathway by glucose deprivation	P04641	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05752	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00053	T cell activation	P01294	NFAT	MOUSE|MGI=MGI=1920431|UniProtKB=Q8K120	Nuclear factor of activated T-cells, cytoplasmic 4	IGI	9462517	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00022	General transcription by RNA polymerase I	P00652	RNA Polymerase I  Complex	HUMAN|HGNC=30346|UniProtKB=Q9NYV6	RNA polymerase I-specific transcription initiation factor RRN3	ISS			PTHR12790:SF0	RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN3-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00056	VEGF signaling pathway	P01422	eNOS	MONDO|Ensembl=ENSMODG00000003903|UniProtKB=F6S3S1	Nitric oxide synthase	ISS	10435050	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	MACMU|Ensembl=ENSMMUG00000017431|UniProtKB=F7HPP3	Uncharacterized protein	ISS	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P02725	Allantoin degradation	P02822	Allantoinase	DEIRA|EnsemblGenome=DR_1153|UniProtKB=Q9RV76	Allantoinase	ISS			PTHR43668:SF2	ALLANTOINASE
P00057	Wnt signaling pathway	P01438	PP2A	RAT|RGD=3380|UniProtKB=P63331	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	IDA	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CAEBR|Gene=CBG18715|UniProtKB=A8XTZ1	Phosphoinositide phospholipase C	ISS			PTHR10336:SF91	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00057	Wnt signaling pathway	P01443	Phospholipase C	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	ORYSJ|EnsemblGenome=OS07G0694000|UniProtKB=Q6Z3Y9	Phosphoinositide phospholipase C	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00053	T cell activation	P01318	PKC-theta	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MOUSE|MGI=MGI=95823|UniProtKB=Q03391	Glutamate receptor ionotropic, NMDA 2D	IC	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	TAS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=15983|UniProtKB=P56704	Protein Wnt-3a	IDA	11266476	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P00004	Alzheimer disease-presenilin pathway	P00178	BACE-1 pro-domain	BOVIN|Ensembl=ENSBTAG00000019365|UniProtKB=Q2HJ40	Beta-secretase 1	ISS	10956649	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00035	Interferon-gamma signaling pathway	P00960	PTP	DROME|FlyBase=FBgn0000382|UniProtKB=P29349	Tyrosine-protein phosphatase corkscrew	TAS	1638629	PubMed	PTHR19134:SF428	TYROSINE-PROTEIN PHOSPHATASE CORKSCREW
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00005	Angiogenesis	P00211	GSK3beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04372	5-Hydroxytryptamine degredation	P04401	Monoamine Oxidase	MOUSE|MGI=MGI=109552|UniProtKB=O09046	L-amino-acid oxidase	ISS			PTHR10742:SF21	L-AMINO-ACID OXIDASE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	MOUSE|MGI=MGI=97355|UniProtKB=P15532	Nucleoside diphosphate kinase A	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P04393	Ras Pathway	P04567	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	10693759	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	TAS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00034	Integrin signalling pathway	P00907	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	8270251	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00049	Parkinson disease	P01225	Synphilin	MACMU|Ensembl=ENSMMUG00000009997|UniProtKB=F6QU58	Uncharacterized protein	ISS	10319874	PubMed	PTHR22882:SF3	SYNPHILIN-1
P00021	FGF signaling pathway	P00636	FGFR1-4	BOVIN|Ensembl=ENSBTAG00000014064|UniProtKB=F1MNW2	Fibroblast growth factor receptor	ISS	10626794	PubMed	PTHR24416:SF130	FIBROBLAST GROWTH FACTOR RECEPTOR 2
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	TAS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	HUMAN|HGNC=9509|UniProtKB=P49810	Presenilin-2	TAS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00004	Alzheimer disease-presenilin pathway	P00125	Ire-1 C-terminal fragment	ARATH|TAIR=AT5G24360|UniProtKB=Q93VJ2	Serine/threonine-protein kinase/endoribonuclease IRE1b	IDA	10619423	PubMed	PTHR13954:SF13	SERINE/THREONINE-PROTEIN KINASE/ENDORIBONUCLEASE IRE1B
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04393	Ras Pathway	P04572	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000003236|UniProtKB=F7DNS6	Uncharacterized protein	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00019	Endothelin signaling pathway	P00588	ET1-4	MACMU|Ensembl=ENSMMUG00000016131|UniProtKB=F7FQK2	Uncharacterized protein	ISS	10884419	PubMed	PTHR13874:SF11	ENDOTHELIN-3
P00030	Hypoxia response via HIF activation	P00825	Thioredoxin	SYNY3|EnsemblGenome=BAA10623|UniProtKB=P52231	Thioredoxin	ISS			PTHR10438:SF215	THIOREDOXIN DOMAIN-CONTAINING PROTEIN, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00051	TCA cycle	P01269	alphaketoglutarate Dehydrogenase	RHOBA|EnsemblGenome=RB9078|UniProtKB=Q7UM46	Alpha-ketoglutarate dehydrogenase E1	IEA	12835416	PubMed	PTHR23152:SF21	2-OXOGLUTARATE DEHYDROGENASE E1 COMPONENT DHKTD1, MITOCHONDRIAL-RELATED
P00057	Wnt signaling pathway	P01443	Phospholipase C	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	IDA	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04393	Ras Pathway	P04572	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	P01458	Protein Kinase C	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00006	Apoptosis signaling pathway	P00269	MAPK	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	ISS	6319455	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00057	Wnt signaling pathway	P01451	Galpha	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00021	FGF signaling pathway	P00646	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	IPI	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04397	p53 pathway by glucose deprivation	P04641	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04546	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	IDA	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00006	Apoptosis signaling pathway	P00269	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04395	Vasopressin synthesis	P04592	Exopeptidase	TAKRU|Ensembl=ENSTRUG00000015779|UniProtKB=H2UTP6	Uncharacterized protein	ISS	1778303	PubMed	PTHR11532:SF59	CARBOXYPEPTIDASE E
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00005	Angiogenesis	P00227	PLA2	MACMU|Ensembl=ENSMMUG00000021423|UniProtKB=F7EEZ1	Phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	HUMAN|HGNC=11641|UniProtKB=Q9NQB0	Transcription factor 7-like 2	TAS	12176738	PubMed	PTHR10373:SF32	TRANSCRIPTION FACTOR 7-LIKE 2
P02749	Leucine biosynthesis	P03000	Branched chain amino acid aminotransferase	CAEEL|WormBase=WBGene00001149|UniProtKB=P54688	Branched-chain-amino-acid aminotransferase, cytosolic	ISS			PTHR11825:SF44	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P00005	Angiogenesis	P00189	Fzd	RAT|RGD=61916|UniProtKB=Q08463	Frizzled-1	ISS	8717036	PubMed	PTHR11309:SF81	FRIZZLED-1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00010	B cell activation	P00381	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00220	c-Jun	XENTR|Xenbase=XB-GENE-482228|UniProtKB=F6RYL1	Uncharacterized protein	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P05912	Dopamine receptor mediated signaling pathway	P05949	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	CHICK|Ensembl=ENSGALG00000007509|UniProtKB=F1NM72	Uncharacterized protein	ISS	87005246	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04547	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P04393	Ras Pathway	P04572	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00048	PI3 kinase pathway	P01185	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00005	Angiogenesis	P00233	CSL	PANTR|Ensembl=ENSPTRG00000015968|UniProtKB=H2R2Q6	Uncharacterized protein	ISS	8406481	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00021	FGF signaling pathway	P00643	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00243	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00981	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000022548|UniProtKB=F6Y9J9	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	BOVIN|Ensembl=ENSBTAG00000009778|UniProtKB=E1BMX0	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00021	FGF signaling pathway	P00632	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00775	Rac	HUMAN|HGNC=688|UniProtKB=Q9H4E5	Rho-related GTP-binding protein RhoJ	TAS	12932731	PubMed	PTHR24072:SF17	RHO-RELATED GTP-BINDING PROTEIN RHOJ
P05915	Opioid proenkephalin pathway	P05994	G-protein	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00018	EGF receptor signaling pathway	P00561	STAT	HUMAN|HGNC=11366|UniProtKB=P42229	Signal transducer and activator of transcription 5A	IGI	8732682	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00034	Integrin signalling pathway	P00911	B-Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	12411479	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00049	Parkinson disease	P01234	GRK	BOVIN|Gene=ADRBK2|UniProtKB=P26818	Beta-adrenergic receptor kinase 2	IDA	8288567	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	IDA	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00052	TGF-beta signaling pathway	P01286	TGFbeta	DANRE|ZFIN=ZDB-GENE-990415-165|UniProtKB=O42222	Growth/differentiation factor 8	TAS	9759503	PubMed	PTHR11848:SF235	GROWTH DIFFERENTIATION FACTOR 8, LIKE-RELATED
P00004	Alzheimer disease-presenilin pathway	P00114	actin	XENTR|Xenbase=XB-GENE-490883|UniProtKB=Q6NVA9	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IDA	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05917	Opioid proopiomelanocortin pathway	P06011	AC	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	DANRE|ZFIN=ZDB-GENE-991119-4|UniProtKB=Q9W6T7	Presenilin-1	IDA	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00045	Notch signaling pathway	P01099	Notch	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00029	Huntington disease	P00763	Hip-12	PANTR|Ensembl=ENSPTRG00000015189|UniProtKB=H2QN22	Intraflagellar transport 57 homolog	ISS			PTHR16011:SF0	INTRAFLAGELLAR TRANSPORT PROTEIN 57 HOMOLOG
P04392	P53 pathway feedback loops 1	P04539	p53	MACMU|Ensembl=ENSMMUG00000016466|UniProtKB=F7GBH1	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00048	PI3 kinase pathway	P01196	PDK1	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	12855688	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IDA	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	MONDO|Ensembl=ENSMODG00000009542|UniProtKB=F7C424	Uncharacterized protein	ISS	9783586	PubMed	PTHR10814:SF21	TRANSDUCIN-LIKE ENHANCER PROTEIN 4
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MOUSE|MGI=MGI=102522|UniProtKB=Q8R3Z5	Voltage-dependent L-type calcium channel subunit beta-1	IC	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00021	FGF signaling pathway	P00629	PP2A	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g177129|UniProtKB=A7RFC7	Serine/threonine-protein phosphatase	ISS			PTHR11668:SF22	SERINE/THREONINE-PROTEIN PHOSPHATASE 4 CATALYTIC SUBUNIT
P00005	Angiogenesis	P00221	JNK1	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	15528206	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00006	Apoptosis signaling pathway	P00310	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06860	Rac1	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	RCA	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00018	EGF receptor signaling pathway	P00558	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IGI	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05923	beta-ARR2	MOUSE|MGI=MGI=99474|UniProtKB=Q91YI4	Beta-arrestin-2	RCA	9388255	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00047	PDGF signaling pathway	P01172	c-Myc	PANTR|Gene=MYC|UniProtKB=P23583	Myc proto-oncogene protein	ISS	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00048	PI3 kinase pathway	P01199	Galpha	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00023	General transcription regulation	P00662	TFIIA complex	YEAST|SGD=S000005720|UniProtKB=P32773	Transcription initiation factor IIA large subunit	ISS	600519	OMIM	PTHR12694:SF8	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1
P00018	EGF receptor signaling pathway	P00561	STAT	CANLF|Ensembl=ENSCAFG00000015213|UniProtKB=E2RB82	Signal transducer and activator of transcription	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	BOVIN|Ensembl=ENSBTAG00000005800|UniProtKB=F1N3G8	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00005	Angiogenesis	P00246	Ang-2	MONDO|Ensembl=ENSMODG00000012086|UniProtKB=F7G4Q4	Uncharacterized protein	ISS	9204896	PubMed	PTHR19143:SF199	ANGIOPOIETIN-2
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00059	p53 pathway	P04623	CBP	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	IDA	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	CHICK|Ensembl=ENSGALG00000015358|UniProtKB=F1NM49	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF575	MYOSIN-15
P00012	Cadherin signaling pathway	P00475	Frizzled	CANLF|Ensembl=ENSCAFG00000013547|UniProtKB=E2QVP7	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF126	FRIZZLED-5
P00019	Endothelin signaling pathway	P00589	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00986	eNOS	BOVIN|Gene=NOS3|UniProtKB=P29473	Nitric oxide synthase, endothelial	ISS	10435050	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	BOVIN|Gene=CACNB1|UniProtKB=Q9MZL7	Voltage-dependent L-type calcium channel subunit beta-1	IDA	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ORYSJ|Gene=Os01g0866100|UniProtKB=P0C540	Actin-7	ISS	14684598	PubMed	PTHR11937:SF205	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01457	GBeta	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IDA	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	HUMAN|HGNC=1394|UniProtKB=O43497	Voltage-dependent T-type calcium channel subunit alpha-1G	TAS	14526084	PubMed	PTHR10037:SF137	VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1G
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00035	Interferon-gamma signaling pathway	P00958	PIAS	ORNAN|Ensembl=ENSOANG00000013547|UniProtKB=F7DN97	Uncharacterized protein	ISS	8682149	PubMed	PTHR10782:SF11	E3 SUMO-PROTEIN LIGASE PIAS1
P00017	DNA replication	P00530	Top	DROME|FlyBase=FBgn0004924|UniProtKB=P30189	DNA topoisomerase 1	RCA			PTHR10290:SF3	DNA TOPOISOMERASE 1
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00629	PP2A	SCHPO|PomBase=SPBC16H5.07c|UniProtKB=P23636	Major serine/threonine-protein phosphatase PP2A-2 catalytic subunit	ISS			PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	PANTR|Ensembl=ENSPTRG00000007489|UniProtKB=H2QA49	Tyrosine-protein kinase receptor	ISS	2877871	PubMed	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00030	Hypoxia response via HIF activation	P00819	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01162	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CAEEL|WormBase=WBGene00001680|UniProtKB=Q20636	Guanine nucleotide-binding protein subunit beta-2	IC	11250160	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00053	T cell activation	P01332	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00011	Blood coagulation	P00447	FVIIa	PANTR|Gene=F7|UniProtKB=Q2F9P2	Coagulation factor VII	ISS	11487022	PubMed	PTHR44064:SF1	COAGULATION FACTOR VII
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05731	GABA-B receptor II signaling	P05755	Gbeta	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00005	Angiogenesis	P00195	APC	DROME|FlyBase=FBgn0015589|UniProtKB=Q9VAS9	APC-like, isoform A	ISS			PTHR12607:SF12	APC-LIKE, ISOFORM A-RELATED
P00018	EGF receptor signaling pathway	P00562	p38	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	IGI	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000006291|UniProtKB=F7GZ76	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF42	PROTOCADHERIN-12
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	CANLF|Ensembl=ENSCAFG00000000875|UniProtKB=F6UTN8	Uncharacterized protein	ISS			PTHR15137:SF9	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2
P06959	CCKR signaling map	P07090	MAPK8-10	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	RCA	12239223	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04494	TSC2	PANTR|Ensembl=ENSPTRG00000031311|UniProtKB=H2R1U8	Uncharacterized protein	ISS	15249583	PubMed	PTHR10063:SF0	TUBERIN
P00007	Axon guidance mediated by semaphorins	P00340	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	MYCTU|EnsemblGenome=Rv2764c|UniProtKB=P9WFR9	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	PANTR|Ensembl=ENSPTRG00000003983|UniProtKB=H2Q4A0	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P04397	p53 pathway by glucose deprivation	P04641	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P06959	CCKR signaling map	P07211	HuR	HUMAN|HGNC=3312|UniProtKB=Q15717	ELAV-like protein 1	RCA	17392515	PubMed	PTHR43938:SF4	ELAV-LIKE PROTEIN 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00048	PI3 kinase pathway	P01192	p110	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	BOVIN|Gene=CXCR2|UniProtKB=Q28003	C-X-C chemokine receptor type 2	ISS	4504683	gi	PTHR10489:SF689	C-X-C CHEMOKINE RECEPTOR TYPE 2
P00019	Endothelin signaling pathway	P00589	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	TAS	176948	OMIM	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01443	Phospholipase C	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00006	Apoptosis signaling pathway	P00311	GCKR	RAT|RGD=1305322|UniProtKB=A0A0G2K7W4	Protein Map4k4	RCA			PTHR24361:SF225	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01072	CHT1	DROME|FlyBase=FBgn0038641|UniProtKB=Q9VE46	High-affinity choline transporter 1	IC			PTHR11819:SF12	HIGH-AFFINITY CHOLINE TRANSPORTER 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00021	FGF signaling pathway	P00634	MEKK1-5	MONDO|Ensembl=ENSMODG00000006594|UniProtKB=F7AKA6	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00056	VEGF signaling pathway	P01413	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=12789|UniProtKB=Q93098	Protein Wnt-8b	TAS	11266476	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04392	P53 pathway feedback loops 1	P04539	p53	MACMU|Ensembl=ENSMMUG00000008639|UniProtKB=P56424	Cellular tumor antigen p53	TAS	11313951	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00019	Endothelin signaling pathway	P00590	IP3 R	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	IGI	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00010	B cell activation	P00380	fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	TAS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000003043|UniProtKB=P63212	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	ORNAN|Ensembl=ENSOANG00000007391|UniProtKB=F6PQH1	Uncharacterized protein	ISS	96032356	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P02753	Methionine biosynthesis	P03024	Homocysteine transmethylase	FUSNN|EnsemblGenome=FN0163|UniProtKB=Q8RGW4	5-methyltetrahydrofolate--homocysteine methyltransferase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IC	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	BOVIN|Ensembl=ENSBTAG00000011723|UniProtKB=E1BKL6	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00053	T cell activation	P01310	Lck	BOVIN|Ensembl=ENSBTAG00000012695|UniProtKB=Q3ZCM0	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF39	TYROSINE-PROTEIN KINASE LCK
P00019	Endothelin signaling pathway	P00587	Raf-1	DROME|FlyBase=FBgn0003079|UniProtKB=P11346	Raf homolog serine/threonine-protein kinase phl	ISS			PTHR44000:SF2	RAF HOMOLOG SERINE/THREONINE-PROTEIN KINASE PHL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	RAT|RGD=2155|UniProtKB=O88656	Actin-related protein 2/3 complex subunit 1B	ISS	12473693	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00023	General transcription regulation	P00664	TFIIH complex	BOVIN|Ensembl=ENSBTAG00000005160|UniProtKB=Q2KJ73	General transcription factor IIH, polypeptide 1, 62kDa	ISS			PTHR12856:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 1
P00008	Axon guidance mediated by Slit/Robo	P00352	DCC	PANTR|Ensembl=ENSPTRG00000010031|UniProtKB=H2QEJ8	Uncharacterized protein	ISS	8861902	PubMed	PTHR44146:SF3	NETRIN RECEPTOR DCC
P00005	Angiogenesis	P00220	c-Jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DROME|FlyBase=FBgn0001105|UniProtKB=P26308	Guanine nucleotide-binding protein subunit beta-1	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P02744	Fructose galactose metabolism	P02960	Galactokinase	PANTR|Ensembl=ENSPTRG00000007052|UniProtKB=H2RDN7	Galactokinase 2	ISS			PTHR10457:SF7	N-ACETYLGALACTOSAMINE KINASE
P00049	Parkinson disease	P01211	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01177	P110ACT	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04669	ATM	HUMAN|HGNC=882|UniProtKB=Q13535	Serine/threonine-protein kinase ATR	TAS	10196661	PubMed	PTHR11139:SF69	SERINE/THREONINE-PROTEIN KINASE ATR
P00047	PDGF signaling pathway	P01145	c-fos	RAT|RGD=2626|UniProtKB=P12841	Proto-oncogene c-Fos	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00010	B cell activation	P00391	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT3G18040|UniProtKB=Q9LV37	Mitogen-activated protein kinase 9	ISS	7106544	gi	PTHR24055:SF246	MITOGEN-ACTIVATED PROTEIN KINASE 15-RELATED
P00005	Angiogenesis	P00200	Dsh	BOVIN|Ensembl=ENSBTAG00000019336|UniProtKB=F1MMW6	Uncharacterized protein	ISS	10409711	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00021	FGF signaling pathway	P00645	Rac	DROME|FlyBase=FBgn0014011|UniProtKB=P48554	Ras-related protein Rac2	ISS	4757952	gi	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ORYSJ|EnsemblGenome=OS10G0510000|UniProtKB=A3C6D7	Actin-2	IDA			PTHR11937:SF252	SUBFAMILY NOT NAMED
P00053	T cell activation	P01311	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IDA	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00624	14-3-3	MOUSE|MGI=MGI=894689|UniProtKB=P62259	14-3-3 protein epsilon	ISS	98119747	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00025	Hedgehog signaling pathway	P00692	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	P00559	MEK1-2	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05918	p38 MAPK pathway	P06018	MNK1	RAT|RGD=1559603|UniProtKB=Q4G050	MAP kinase-interacting serine/threonine-protein kinase 1	ISS	11575158	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	RAT|RGD=1307025|UniProtKB=P85515	Alpha-centractin	ISS	14684598	PubMed	PTHR11937:SF46	ALPHA-CENTRACTIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05915	Opioid proenkephalin pathway	P05993	AC	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02743	Formyltetrahydroformate biosynthesis	P02954	Thymidylate synthase	LEIMA|Gene=LmjF06.0860|UniProtKB=P07382	Bifunctional dihydrofolate reductase-thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00057	Wnt signaling pathway	P01428	Frizzled	XENTR|Xenbase=XB-GENE-484322|UniProtKB=F6RPG1	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF22	FRIZZLED-3
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05915	Opioid proenkephalin pathway	P05994	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	PLAF7|EnsemblGenome=PFI1020c|UniProtKB=Q8I2U5	Inosine-5'-monophosphate dehydrogenase	ISS			PTHR43170:SF4	GMP REDUCTASE 2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	1504106	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00545	JNK1-3	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00056	VEGF signaling pathway	P01409	cPLA2	MACMU|Ensembl=ENSMMUG00000003842|UniProtKB=F7HAF3	Phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF32	CYTOSOLIC PHOSPHOLIPASE A2 BETA
P00019	Endothelin signaling pathway	P00586	Gq	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00021	FGF signaling pathway	P00629	PP2A	DICPU|Gene=DICPUDRAFT_98650|UniProtKB=F0ZSC4	Phosphoprotein phosphatase A	ISS			PTHR10648:SF4	PROTEIN PHOSPHATASE 2  FORMERLY 2A , REGULATORY SUBUNIT A, BETA ISOFORM
P00053	T cell activation	P01311	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00025	Hedgehog signaling pathway	P00692	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-050417-59|UniProtKB=Q15KE4	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04393	Ras Pathway	P04561	SRF	RAT|RGD=1559787|UniProtKB=D3ZHH8	Protein Srf	ISS	15326221	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00006	Apoptosis signaling pathway	P00269	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00785	Cytochrome c	MACMU|Ensembl=ENSMMUG00000007149|UniProtKB=F7DMP6	Uncharacterized protein	ISS	15163634	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=98955|UniProtKB=P17553	Proto-oncogene Wnt-3	IDA	11266476	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00047	PDGF signaling pathway	P01168	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00931	Integrin beta	BOVIN|Ensembl=ENSBTAG00000009987|UniProtKB=F1MTN1	Integrin beta	ISS	386150	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01444	Wnt	PANTR|Ensembl=ENSPTRG00000002064|UniProtKB=H2R817	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	CANLF|Ensembl=ENSCAFG00000010390|UniProtKB=E2RE39	Adenylate kinase 2, mitochondrial	ISS			PTHR23359:SF117	ADENYLATE KINASE 2, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=12775|UniProtKB=O00744	Protein Wnt-10b	IDA	12549854	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P02784	Tyrosine biosynthesis	P03214	Prephenate dehydrogenase	STRCO|Gene=CAD55177|UniProtKB=Q8CK19	Putative cyclohexadienyl dehydrogenase	ISS			PTHR21363:SF0	PREPHENATE DEHYDROGENASE  NADP +
P02781	Threonine biosynthesis	P03190	Threonine synthase	SULSO|EnsemblGenome=SSO0493|UniProtKB=Q97ZT5	Threonine synthase (ThrC-1)	ISS			PTHR10314:SF78	SUBFAMILY NOT NAMED
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00012	Cadherin signaling pathway	P00474	Wnt	MONDO|Ensembl=ENSMODG00000018415|UniProtKB=F6XUZ7	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	HUMAN|HGNC=9509|UniProtKB=P49810	Presenilin-2	IDA	12846562	PubMed	PTHR10202:SF13	PRESENILIN-2
P00017	DNA replication	P00533	Pol delta	HUMAN|HGNC=9175|UniProtKB=P28340	DNA polymerase delta catalytic subunit	ISS	9620226	PubMed	PTHR10322:SF23	DNA POLYMERASE DELTA CATALYTIC SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02723	Adenine and hypoxanthine salvage pathway	P02808	Deoxyadenosine phosphorylase	ANOGA|EnsemblGenome=AGAP005945|UniProtKB=A4Q998	AGAP005945-PA	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00029	Huntington disease	P00797	p53	DROME|FlyBase=FBgn0038320|UniProtKB=Q9VF87	Cytoplasmic FMR1-interacting protein	TAS			PTHR12195:SF0	CYTOPLASMIC FMR1-INTERACTING PROTEIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00897	SHIP2	PANTR|Ensembl=ENSPTRG00000004031|UniProtKB=H2Q4C6	Inositol polyphosphate phosphatase-like 1	ISS	10610720	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	ARATH|TAIR=AT4G34460|UniProtKB=P49177	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF48	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000004741|UniProtKB=H2Q5K0	Uncharacterized protein	ISS			PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00951	Jnk	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00009	Axon guidance mediated by netrin	P00363	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	ISS	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P00036	Interleukin signaling pathway	P00970	Interleukin	HUMAN|HGNC=6025|UniProtKB=P10145	Interleukin-8	TAS	2007144	PubMed	PTHR10179:SF70	INTERLEUKIN-8
P00019	Endothelin signaling pathway	P00584	Gs	MOUSE|MGI=MGI=95777|UniProtKB=Q6R0H7	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas	RCA			PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	PANTR|Ensembl=ENSPTRG00000020039|UniProtKB=H2R9W1	Uncharacterized protein	ISS	11443533	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00012	Cadherin signaling pathway	P00471	Cadherin	BOVIN|Ensembl=ENSBTAG00000012992|UniProtKB=Q3SWX5	Cadherin-6	ISS	8120095	PubMed	PTHR24027:SF322	CADHERIN-6
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	XENTR|Xenbase=XB-GENE-482409|UniProtKB=F6UK84	Uncharacterized protein (Fragment)	ISS	11861821	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MACMU|Ensembl=ENSMMUG00000012054|UniProtKB=F6TII3	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00053	T cell activation	P01316	MHC-antigen	BOVIN|Ensembl=ENSBTAG00000038128|UniProtKB=F1N0X9	Uncharacterized protein	IPI	73139	PubMed	PTHR19944:SF59	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DQ ALPHA 1 CHAIN
P04393	Ras Pathway	P04578	Rho	CHICK|Ensembl=ENSGALG00000016485|UniProtKB=O93468	GTP-binding protein	ISS	11973360	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00047	PDGF signaling pathway	P01162	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00047	PDGF signaling pathway	P01142	p90RSK	PANTR|Ensembl=ENSPTRG00000000387|UniProtKB=H2PYE3	Ribosomal protein S6 kinase	ISS	12769834	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00006	Apoptosis signaling pathway	P00321	HSP70	PHYPA|Gene=PHYPADRAFT_158543|UniProtKB=A9RCV9	Predicted protein	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P02778	Sulfate assimilation	P03167	Sulfate adenylyltransferase	CRYNJ|EnsemblGenome=CNI03560|UniProtKB=P0CN04	Sulfate adenylyltransferase	ISS			PTHR42700:SF1	SULFATE ADENYLYLTRANSFERASE
P02766	Phenylethylamine degradation	P03103	Phenylethylamine oxidase	ARATH|TAIR=AT3G43670|UniProtKB=Q9M2B9	Amine oxidase	ISS			PTHR10638:SF38	AMINE OXIDASE-RELATED
P00049	Parkinson disease	P01238	14-3-3	CANLF|Ensembl=ENSCAFG00000000580|UniProtKB=F1PBL1	Uncharacterized protein	ISS	12615066	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00023	General transcription regulation	P00658	TBP-associated factors	SCHPO|PomBase=SPCC16C4.18c|UniProtKB=O74462	Transcription initiation factor TFIID subunit 6	ISS			PTHR10221:SF9	TAF6-LIKE RNA POLYMERASE II P300/CBP-ASSOCIATED FACTOR-ASSOCIATED FACTOR 65 KDA SUBUNIT 6L
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00147	TACE	HUMAN|HGNC=195|UniProtKB=P78536	Disintegrin and metalloproteinase domain-containing protein 17	TAS	12834808	PubMed	PTHR11905:SF171	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MOUSE|MGI=MGI=104589|UniProtKB=P63268	Actin, gamma-enteric smooth muscle	IDA	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P02738	De novo purine biosynthesis	P02891	GDP kinase	ANOGA|EnsemblGenome=AGAP007120|UniProtKB=Q7QIX6	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	AQUAE|EnsemblGenome=aq_479|UniProtKB=O66776	Serine hydroxymethyltransferase	ISS			PTHR11680:SF21	SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000035697|UniProtKB=Q28024	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00023	General transcription regulation	P00664	TFIIH complex	MONDO|Ensembl=ENSMODG00000015851|UniProtKB=F7F0D8	Uncharacterized protein	ISS			PTHR13152:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4
P00021	FGF signaling pathway	P00645	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	TAKRU|Ensembl=ENSTRUG00000008289|UniProtKB=H2T7U8	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF129	CDC42L PROTEIN
P05913	Enkephalin release	P05972	PKA	LEIMA|EnsemblGenome=LmjF.35.3960|UniProtKB=E9AFM1	Protein kinase A catalytic subunit isoform 2	ISS	10553940	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00272	ASK1	MACMU|Ensembl=ENSMMUG00000016376|UniProtKB=F7G2W1	Uncharacterized protein	ISS	12566458	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00053	T cell activation	P01332	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00624	14-3-3	CHLRE|EnsemblGenome=CHLREDRAFT_185967|UniProtKB=A8JGV6	14-3-3 protein	ISS	95359208	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00004	Alzheimer disease-presenilin pathway	P00167	CD44 transmembrane fragment	MACMU|Ensembl=ENSMMUG00000004327|UniProtKB=F6ZDZ8	Uncharacterized protein	ISS	14871815	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P00005	Angiogenesis	P00211	GSK3beta	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	MOUSE|MGI=MGI=106677|UniProtKB=Q8BRU6	Synaptic vesicular amine transporter	ISS	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00019	Endothelin signaling pathway	P00589	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00821	Prolyl Hydroxylase	PANTR|Ensembl=ENSPTRG00000011010|UniProtKB=G2HG38	Egl nine homolog 2	ISS	12912907	PubMed	PTHR12907:SF6	EGL NINE HOMOLOG 2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00018	EGF receptor signaling pathway	P00542	EGFR	MOUSE|MGI=MGI=95411|UniProtKB=Q61526	Receptor tyrosine-protein kinase erbB-3	ISS	20477399	gi	PTHR24416:SF88	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MACMU|Ensembl=ENSMMUG00000004048|UniProtKB=F6ZR92	Frizzled-4	ISS	11212302	PubMed	PTHR11309:SF23	FRIZZLED-4
P04395	Vasopressin synthesis	P04589	Signal Peptidase	ARATH|TAIR=AT1G52600|UniProtKB=Q9SSR2	Signal peptidase I	IC	2674115	PubMed	PTHR10806:SF16	SIGNAL PEPTIDASE I
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DANRE|ZFIN=ZDB-GENE-000322-1|UniProtKB=Q9I8V1	Actin, alpha 1, skeletal muscle	IDA	14684598	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	PANTR|Ensembl=ENSPTRG00000015689|UniProtKB=H2QNV3	Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 2	ISS			PTHR10943:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2
P00059	p53 pathway	P04612	HDAC1	BOVIN|Ensembl=ENSBTAG00000012698|UniProtKB=Q32PJ8	Histone deacetylase 1	ISS	12665570	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02917	Ribonucleoside triphosphate Reductase	THEMA|EnsemblGenome=TM_0385|UniProtKB=Q9WYL6	Ribonucleotide reductase of class III (Anaerobic), large subunit	ISS			PTHR21075:SF0	ANAEROBIC RIBONUCLEOSIDE-TRIPHOSPHATE REDUCTASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	IC	2303451	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00010	B cell activation	P00383	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	PANTR|Ensembl=ENSPTRG00000003106|UniProtKB=H2R5P6	Uncharacterized protein	ISS	99239941	PubMed	PTHR10539:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	ARATH|TAIR=AT3G47220|UniProtKB=Q6NMA7	Phosphoinositide phospholipase C 9	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	HUMAN|HGNC=5294|UniProtKB=P41595	5-hydroxytryptamine receptor 2B	IDA			PTHR24247:SF31	5-HYDROXYTRYPTAMINE RECEPTOR 2B
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	ARATH|TAIR=AT5G61210|UniProtKB=Q9S7P9	SNAP25 homologous protein SNAP33	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MACMU|Ensembl=ENSMMUG00000005186|UniProtKB=F7CYA2	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF42	REGULATOR OF G-PROTEIN SIGNALING 5
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	CAEEL|WormBase=WBGene00001745|UniProtKB=Q7KPV0	G protein, Subunit Alpha	ISS			PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	NAS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00034	Integrin signalling pathway	P00912	Arp2/3	MOUSE|MGI=MGI=1928375|UniProtKB=Q9JM76	Actin-related protein 2/3 complex subunit 3	ISS	9359840	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01411	Ras	XENTR|Xenbase=XB-GENE-494548|UniProtKB=F7EC26	Uncharacterized protein	ISS	20362513	PubMed	PTHR24070:SF186	GTPASE KRAS
P00008	Axon guidance mediated by Slit/Robo	P00352	DCC	RAT|RGD=2492|UniProtKB=Q63155	Netrin receptor DCC	ISS	8861902	PubMed	PTHR44146:SF3	NETRIN RECEPTOR DCC
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00019	Endothelin signaling pathway	P00591	PLCbeta	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00057	Wnt signaling pathway	P01428	Frizzled	XENTR|Xenbase=XB-GENE-487022|UniProtKB=F6SH04	Uncharacterized protein (Fragment)	ISS	11212302	PubMed	PTHR11309:SF34	FRIZZLED-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=1309423|UniProtKB=A0A0G2K528	Protein Stx16	ISS			PTHR19957:SF83	SYNTAXIN-16
P00054	Toll receptor signaling pathway	P01369	MKK1	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00034	Integrin signalling pathway	P00906	Rap1	RAT|RGD=620591|UniProtKB=P61227	Ras-related protein Rap-2b	ISS	8576107	PubMed	PTHR24070:SF194	RAS-RELATED PROTEIN RAP-2B
P00054	Toll receptor signaling pathway	P01375	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	IDA	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00019	Endothelin signaling pathway	P00586	Gq	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00053	T cell activation	P01319	PAK	CANLF|Ensembl=ENSCAFG00000013067|UniProtKB=E2RJA0	Uncharacterized protein	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00012	Cadherin signaling pathway	P00470	F-actin	DICPU|Gene=DICPUDRAFT_90232|UniProtKB=F1A175	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00049	Parkinson disease	P01241	TH	CHICK|Ensembl=ENSGALG00000006551|UniProtKB=F6RRW6	Uncharacterized protein	TAS	12814656	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00019	Endothelin signaling pathway	P00570	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00931	Integrin beta	MOUSE|MGI=MGI=96612|UniProtKB=O54890	Integrin beta-3	IDA	124968	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00056	VEGF signaling pathway	P01408	Akt/PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00029	Huntington disease	P00775	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MOUSE|MGI=MGI=1933206|UniProtKB=A2AIR5	Protein Grin3a	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P04373	5HT1 type receptor mediated signaling pathway	P04409	5HT transporter	CANLF|Ensembl=ENSCAFG00000018990|UniProtKB=F1PXA1	Transporter	ISS	14653308	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P00021	FGF signaling pathway	P00629	PP2A	MONDO|Ensembl=ENSMODG00000016691|UniProtKB=F7DLW2	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B (Fragment)	ISS	137056	PubMed	PTHR11871:SF2	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B ALPHA ISOFORM
P00029	Huntington disease	P00786	ARF	DANRE|ZFIN=ZDB-GENE-050417-265|UniProtKB=Q561U6	ADP-ribosylation factor-like 4Ca	ISS	12932731	PubMed	PTHR11711:SF119	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 4C
P00053	T cell activation	P01322	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02738	De novo purine biosynthesis	P02902	ADP reductase	AQUAE|EnsemblGenome=aq_094|UniProtKB=O66503	Ribonucleoside-diphosphate reductase subunit alpha	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00030	Hypoxia response via HIF activation	P00819	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05913	Enkephalin release	P05971	CREB	RAT|RGD=620218|UniProtKB=P15337	Cyclic AMP-responsive element-binding protein 1	ISS	11752053	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00021	FGF signaling pathway	P00640	PI3K	DROME|FlyBase=FBgn0015278|UniProtKB=Q7K3H0	LD28067p	IGI	14526383	PubMed	PTHR10048:SF64	LD28067P
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	PANTR|Ensembl=ENSPTRG00000008411|UniProtKB=H2QBM1	Uncharacterized protein	ISS	20355009	PubMed	PTHR15319:SF1	TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT C
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DROME|FlyBase=FBgn0004623|UniProtKB=P29829	Guanine nucleotide-binding protein subunit beta-2	IC			PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	CANLF|Ensembl=ENSCAFG00000017040|UniProtKB=E2QYK5	Uncharacterized protein	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00547	PP2A	XENTR|Xenbase=XB-GENE-957248|UniProtKB=Q6GLE6	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	RAT|RGD=2246|UniProtKB=Q07652	Voltage-dependent R-type calcium channel subunit alpha-1E	IDA	8386525	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00057	Wnt signaling pathway	P01451	Galpha	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	IDA	8836152	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00034	Integrin signalling pathway	P00916	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IPI	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS			PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04395	Vasopressin synthesis	P04589	Signal Peptidase	MOUSE|MGI=MGI=1913874|UniProtKB=Q9CYN2	Signal peptidase complex subunit 2	ISS	7788527	PubMed	PTHR13085:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 2
P00049	Parkinson disease	P01227	20S proteasome	BOVIN|Ensembl=ENSBTAG00000002808|UniProtKB=Q58DU5	Proteasome subunit alpha type-3	ISS	12859888	PubMed	PTHR11599:SF10	PROTEASOME SUBUNIT ALPHA TYPE-3
P00057	Wnt signaling pathway	P01465	Ggamma	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04393	Ras Pathway	P04546	GSK3	STRPU|EnsemblGenome=SPU_009263|UniProtKB=W4Y0P1	Uncharacterized protein	ISS	9609832	PubMed	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	TAS			PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00059	p53 pathway	P04623	CBP	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00057	Wnt signaling pathway	P01472	Histone deacetylase	ORNAN|Ensembl=ENSOANG00000003631|UniProtKB=F7FJQ1	Histone deacetylase	ISS	12665570	PubMed	PTHR10625:SF171	HISTONE DEACETYLASE 2
P00059	p53 pathway	P01486	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00034	Integrin signalling pathway	P00916	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MOUSE|MGI=MGI=103307|UniProtKB=P54285	Voltage-dependent L-type calcium channel subunit beta-3	IC			PTHR11824:SF8	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-3
P05731	GABA-B receptor II signaling	P05760	AC	HUMAN|HGNC=236|UniProtKB=O95622	Adenylate cyclase type 5	ISS	2491850	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P04393	Ras Pathway	P04559	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	IDA	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P05913	Enkephalin release	P05972	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01152	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00006	Apoptosis signaling pathway	P00321	HSP70	ORYSJ|EnsemblGenome=OS03G0276500|UniProtKB=Q10NA9	70 kDa heat shock protein	ISS	12150907	PubMed	PTHR19375:SF243	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00551	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05755	Gbeta	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DROME|FlyBase=FBgn0011743|UniProtKB=P45891	Actin-like protein 53D	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	TAS	10395542	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00046	Oxidative stress response	P01131	MKP5	MOUSE|MGI=MGI=1927070|UniProtKB=Q9ESS0	Dual specificity protein phosphatase 10	TAS	10597297	PubMed	PTHR10159:SF299	DUAL SPECIFICITY PROTEIN PHOSPHATASE 10
P00019	Endothelin signaling pathway	P00566	ERK	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	CANLF|Ensembl=ENSCAFG00000015905|UniProtKB=E2QUH6	Uncharacterized protein	ISS	11742073	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00019	Endothelin signaling pathway	P00591	PLCbeta	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00052	TGF-beta signaling pathway	P01275	P38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	TAS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00021	FGF signaling pathway	P00628	JNK1-3	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00024	Glycolysis	P00678	Enolase	ARATH|TAIR=AT2G36530|UniProtKB=P25696	Bifunctional enolase 2/transcriptional activator	IC	15809970	gi	PTHR11902:SF1	ENOLASE
P00021	FGF signaling pathway	P00642	MEK1-2	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00562	p38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IDA	91072385	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04570	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00928	alpha actinin	XENTR|Xenbase=XB-GENE-494339|UniProtKB=F6V4J5	Uncharacterized protein (Fragment)	ISS	2116421	PubMed	PTHR43947:SF7	ALPHA-ACTININ-4
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	LEIMA|EnsemblGenome=LmjF.35.4010|UniProtKB=Q9GNR4	Protein kinase A catalytic subunit isoform 1	IC	14744463	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00539	14-3-3	DAPPU|EnsemblGenome=DAPPUDRAFT_307391|UniProtKB=E9H1W5	14-3-3 zeta	ISS	10407019	PubMed	PTHR18860:SF13	14-3-3 PROTEIN ZETA
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	P01431	LRP5/6	RAT|RGD=1309329|UniProtKB=F1MAD0	Protein Lrp5	ISS	11029006	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00034	Integrin signalling pathway	P00910	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8479536	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00006	Apoptosis signaling pathway	P00269	MAPK	ORYSJ|EnsemblGenome=OS03G0285800|UniProtKB=Q10N20	Mitogen-activated protein kinase 5	ISS	8388749	PubMed	PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01319	PAK	CHICK|Ensembl=ENSGALG00000006426|UniProtKB=E1BS97	Uncharacterized protein	ISS	10644687	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT3G45640|UniProtKB=Q39023	Mitogen-activated protein kinase 3	ISS	10514528	PubMed	PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05918	p38 MAPK pathway	P06040	MSK1	BOVIN|Ensembl=ENSBTAG00000010906|UniProtKB=E1BN61	Ribosomal protein S6 kinase	ISS	9687510	PubMed	PTHR24351:SF115	RIBOSOMAL PROTEIN S6 KINASE ALPHA-5
P00056	VEGF signaling pathway	P01421	Rac	HUMAN|HGNC=31682|UniProtKB=P85299	Proline-rich protein 5	ISS			PTHR32428:SF4	PROLINE-RICH PROTEIN 5
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	10693759	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04392	P53 pathway feedback loops 1	P04539	p53	MOUSE|MGI=MGI=98834|UniProtKB=P02340	Cellular tumor antigen p53	TAS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00029	Huntington disease	P00775	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	10891487	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00053	T cell activation	P01322	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IGI	7937853	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P05734	Synaptic vesicle trafficking	P05773	Munc13	CANLF|Ensembl=ENSCAFG00000002030|UniProtKB=F1P9F6	Uncharacterized protein	ISS	605836	OMIM	PTHR10480:SF8	PROTEIN UNC-13 HOMOLOG B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	TAS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04393	Ras Pathway	P04546	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	IDA	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02756	N-acetylglucosamine metabolism	P03036	N-acetylglucosamine-6-phosphate deacetylase	DROME|FlyBase=FBgn0031099|UniProtKB=Q9VR81	N-acetylglucosamine-6-phosphate deacetylase	ISS			PTHR11113:SF14	N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05913	Enkephalin release	P05971	CREB	MONDO|Ensembl=ENSMODG00000015970|UniProtKB=F7FD05	Uncharacterized protein	ISS	11752053	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00052	TGF-beta signaling pathway	P01284	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00034	Integrin signalling pathway	P00947	Laminin	MOUSE|MGI=MGI=99916|UniProtKB=Q61292	Laminin subunit beta-2	IPI	2538453	PubMed	PTHR10574:SF36	LAMININ SUBUNIT BETA-2
P00018	EGF receptor signaling pathway	P00548	RKIP	ORYSJ|EnsemblGenome=OS11G0152500|UniProtKB=Q53Q71	CEN-like protein 2, putative, expressed	ISS			PTHR11362:SF13	PROTEIN TERMINAL FLOWER 1
P05731	GABA-B receptor II signaling	P05752	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00047	PDGF signaling pathway	P01167	Ets	DROME|FlyBase=FBgn0003118|UniProtKB=P51023	ETS-like protein pointed, isoform P2/D	ISS	15298723	PubMed	PTHR11849:SF265	ETS-LIKE PROTEIN POINTED, ISOFORM P2/D
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	HUMAN|HGNC=16059|UniProtKB=O96013	Serine/threonine-protein kinase PAK 4	ISS			PTHR24361:SF345	SERINE/THREONINE-PROTEIN KINASE PAK 4
P00021	FGF signaling pathway	P00638	PLCgamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04413	K+ channel	MOUSE|MGI=MGI=3521816|UniProtKB=Q3LS21	Potassium channel subfamily K member 9	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	SCHPO|PomBase=SPBC14C8.06|UniProtKB=P78774	Actin-related protein 2/3 complex subunit 1	ISS	12932731	PubMed	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P00008	Axon guidance mediated by Slit/Robo	P00344	Netrin	HUMAN|HGNC=8029|UniProtKB=O95631	Netrin-1	ISS	9427245	PubMed	PTHR10574:SF365	NETRIN-1
P00049	Parkinson disease	P01210	UCH-L1	RAT|RGD=3928|UniProtKB=Q00981	Ubiquitin carboxyl-terminal hydrolase isozyme L1	ISS	12408865	PubMed	PTHR10589:SF19	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L1
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	CAEEL|WormBase=WBGene00004769|UniProtKB=P52166	Presenilin sel-12	IDA	7566091	PubMed	PTHR10202:SF13	PRESENILIN-2
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	CANLF|Ensembl=ENSCAFG00000002528|UniProtKB=F1PS63	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF61	TGF-BETA RECEPTOR TYPE-1
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	RAT|RGD=2746|UniProtKB=P31424	Metabotropic glutamate receptor 5	ISS	12488551	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Gene=OPRM1|UniProtKB=Q5IS39	Mu-type opioid receptor	ISS	11259498	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	IPI	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00029	Huntington disease	P00778	NMDA receptor	RAT|RGD=621705|UniProtKB=Q8VHN2	Glutamate receptor ionotropic, NMDA 3B	IDA	11319238	PubMed	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P02775	Salvage pyrimidine ribonucleotides	P03149	Cytidine kinase	ECOLI|EcoGene=EG11701|UniProtKB=P0A8F4	Uridine kinase	ISS			PTHR10285:SF6	ATP-DEPENDENT KINASE TDA10-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	RAT|RGD=69319|UniProtKB=P54313	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00015	Circadian clock system	P00505	Cry	ARATH|TAIR=AT4G08920|UniProtKB=Q43125	Cryptochrome-1	ISS			PTHR11455:SF18	DEOXYRIBODIPYRIMIDINE PHOTO-LYASE, MITOCHONDRIAL
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00006	Apoptosis signaling pathway	P00274	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	ARATH|TAIR=AT5G18170|UniProtKB=Q43314	Glutamate dehydrogenase 1	ISS			PTHR11606:SF18	GLUTAMATE DEHYDROGENASE 1-RELATED
P00025	Hedgehog signaling pathway	P00692	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00057	Wnt signaling pathway	P01465	Ggamma	CANLF|Ensembl=ENSCAFG00000028654|UniProtKB=J9P702	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00018	EGF receptor signaling pathway	P00539	14-3-3	CANLF|Ensembl=ENSCAFG00000000580|UniProtKB=F1PBL1	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00012	Cadherin signaling pathway	P00475	Frizzled	DROME|FlyBase=FBgn0027343|UniProtKB=O77438	Frizzled-3	IDA	11212302	PubMed	PTHR11309:SF125	FRIZZLED-3
P00010	B cell activation	P00381	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00951	Jnk	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IDA	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00243	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02746	Heme biosynthesis	P02975	Uroporphyrinogen decarboxylase	NEUCR|EnsemblGenome=EFNCRG00000002363|UniProtKB=Q7SE23	Uroporphyrinogen decarboxylase	ISS			PTHR21091:SF2	UROPORPHYRINOGEN DECARBOXYLASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01094	gamma	CANLF|Ensembl=ENSCAFG00000024807|UniProtKB=F6XNB0	Uncharacterized protein	ISS	95224005	PubMed	PTHR18945:SF60	ACETYLCHOLINE RECEPTOR SUBUNIT GAMMA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IDA	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00023	General transcription regulation	P00661	TTF2	HUMAN|HGNC=12397|UniProtKB=Q15361	Transcription termination factor 1	IGI			PTHR10641:SF939	TRANSCRIPTION TERMINATION FACTOR 1
P00021	FGF signaling pathway	P00634	MEKK1-5	RAT|RGD=1304575|UniProtKB=B5DF98	Map3k3 protein	ISS	8649450	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00189	Fzd	MACMU|Ensembl=ENSMMUG00000022114|UniProtKB=F7H7V5	Uncharacterized protein	ISS	12549854	PubMed	PTHR11309:SF81	FRIZZLED-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	RAT|RGD=2851|UniProtKB=P35364	5-hydroxytryptamine receptor 5A	IDA			PTHR24247:SF108	5-HYDROXYTRYPTAMINE RECEPTOR 5A
P00021	FGF signaling pathway	P00624	14-3-3	XENTR|Xenbase=XB-GENE-951350|UniProtKB=Q0V9W8	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	ISS	8381897	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00005	Angiogenesis	P00223	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	RAT|RGD=621348|UniProtKB=Q9QXQ5	Protein Wnt-4	TAS	11266476	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BOVIN|Ensembl=ENSBTAG00000020221|UniProtKB=E1BDG5	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P04397	p53 pathway by glucose deprivation	P04641	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	HUMAN|HGNC=10447|UniProtKB=P10301	Ras-related protein R-Ras	ISS	7997267	PubMed	PTHR24070:SF245	RAS-RELATED PROTEIN R-RAS
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	HUMAN|HGNC=15906|UniProtKB=A7E2Y1	Myosin-7B	ISS	10938134	PubMed	PTHR13140:SF358	MYOSIN-7B
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	XENTR|Xenbase=XB-GENE-963560|UniProtKB=Q0VFC4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04393	Ras Pathway	P04574	PLD	RAT|RGD=3350|UniProtKB=P70498	Phospholipase D2	IDA	9538008	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P05731	GABA-B receptor II signaling	P05753	Ca channel	BOVIN|Ensembl=ENSBTAG00000007882|UniProtKB=G3X7Z2	Uncharacterized protein	ISS	8386525	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00049	Parkinson disease	P01236	Casein kinase II	CANAL|CGD=CAL0005264|UniProtKB=Q5ACW5	Casein kinase II subunit beta	IDA	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	CAEEL|WormBase=WBGene00004287|UniProtKB=Q94124	Ras-related protein rac-2	ISS	22392988	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00047	PDGF signaling pathway	P01175	Shc	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	ISS	7680960	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	TAS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00049	Parkinson disease	P01221	Torsin A	MONDO|Ensembl=ENSMODG00000006810|UniProtKB=F6PGK6	Uncharacterized protein	ISS	12421356	PubMed	PTHR10760:SF15	TORSIN-1A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00035	Interferon-gamma signaling pathway	P00959	IFNGR1	MOUSE|MGI=MGI=107655|UniProtKB=P15261	Interferon gamma receptor 1	TAS	11358460	PubMed	PTHR20859:SF5	INTERFERON GAMMA RECEPTOR 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00059	p53 pathway	P04623	CBP	ARATH|TAIR=AT3G12980|UniProtKB=Q9LE42	Histone acetyltransferase HAC5	IDA	10664585	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00034	Integrin signalling pathway	P00944	Actin	CAEEL|WormBase=WBGene00000067|UniProtKB=O45815	ACTin	ISS	10974003	PubMed	PTHR11937:SF352	ACTIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00010	B cell activation	P00402	Jnk	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	CHICK|Ensembl=ENSGALG00000007509|UniProtKB=F1NM72	Uncharacterized protein	ISS	6309844	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00718	Phosphorylase a	MONDO|Ensembl=ENSMODG00000006424|UniProtKB=F7EZJ9	Alpha-1,4 glucan phosphorylase (Fragment)	ISS	4318782	PubMed	PTHR11468:SF1	GLYCOGEN PHOSPHORYLASE, BRAIN FORM
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000005917|UniProtKB=F6QM53	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00736	CalDAG-GEF	PANTR|Ensembl=ENSPTRG00000011824|UniProtKB=H2QHQ8	Uncharacterized protein	ISS	10835426	PubMed	PTHR23113:SF178	RAS GUANYL-RELEASING PROTEIN 3
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	PANTR|Ensembl=ENSPTRG00000004964|UniProtKB=H2Q5Y6	Receptor protein serine/threonine kinase	ISS	10683140	PubMed	PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IGI	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	RAT|RGD=1561153|UniProtKB=F1M885	Protein Myo7b	ISS			PTHR13140:SF505	UNCONVENTIONAL MYOSIN-VIIB
P00018	EGF receptor signaling pathway	P00560	Raf-1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01425	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	DANRE|ZFIN=ZDB-GENE-050417-441|UniProtKB=Q567Y8	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00981	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00047	PDGF signaling pathway	P01160	IP3 receptor	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	IDA	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PRIPA|Gene=PPA19914|UniProtKB=H3FCG4	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF359	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000002775|UniProtKB=H2RB55	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00012	Cadherin signaling pathway	P00463	betacatenin	MACMU|Ensembl=ENSMMUG00000014627|UniProtKB=F7GNE4	Catenin beta-1	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Gene=CHRM2|UniProtKB=Q9N2A7	Muscarinic acetylcholine receptor M2 (Fragment)	ISS	11166329	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05753	Ca channel	MOUSE|MGI=MGI=109482|UniProtKB=P97445	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	14624853	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00036	Interleukin signaling pathway	P00962	ELK	MOUSE|MGI=MGI=102853|UniProtKB=P41158	ETS domain-containing protein Elk-4	ISS	11846562	PubMed	PTHR11849:SF21	ETS DOMAIN-CONTAINING PROTEIN ELK-4
P05730	Endogenous cannabinoid signaling	P05751	Galpha	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	RCA	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00034	Integrin signalling pathway	P00930	Dock180	HUMAN|HGNC=2987|UniProtKB=Q14185	Dedicator of cytokinesis protein 1	RCA			PTHR23317:SF79	DEDICATOR OF CYTOKINESIS PROTEIN 1
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00017	DNA replication	P00538	RNase H	HUMAN|HGNC=18466|UniProtKB=O60930	Ribonuclease H1	IDA	12473655	PubMed	PTHR10642:SF0	RIBONUCLEASE H1
P00010	B cell activation	P00384	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00049	Parkinson disease	P01230	Src kinase	MOUSE|MGI=MGI=95527|UniProtKB=P14234	Tyrosine-protein kinase Fgr	IDA	11078745	PubMed	PTHR24418:SF224	TYROSINE-PROTEIN KINASE FGR
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	ORNAN|Ensembl=ENSOANG00000006699|UniProtKB=F6ULE6	Uncharacterized protein	ISS	9043084	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	IC	15621031	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00018	EGF receptor signaling pathway	P00557	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	SCHPO|PomBase=SPAC458.05|UniProtKB=P50520	Phosphatidylinositol 3-kinase vps34	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00047	PDGF signaling pathway	P01151	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IGI	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00056	VEGF signaling pathway	P01421	Rac	CAEEL|WormBase=WBGene00012203|UniProtKB=Q23130	Rho GTPase Activating protein	ISS			PTHR23176:SF0	RHO GTPASE-ACTIVATING PROTEIN 68F
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04665	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00470	F-actin	CANLF|Ensembl=ENSCAFG00000012181|UniProtKB=F2Z4N7	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CANLF|Ensembl=ENSCAFG00000010787|UniProtKB=E2R3W6	Uncharacterized protein	ISS	2137198	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00006	Apoptosis signaling pathway	P00322	Cytochrome C	CAEEL|WormBase=WBGene00013854|UniProtKB=Q23240	Probable cytochrome c 2.2	ISS			PTHR11961:SF7	CYTOCHROME C 2.2-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	RCA	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	CANLF|Ensembl=ENSCAFG00000001534|UniProtKB=F1PDW7	Uncharacterized protein	ISS	9783586	PubMed	PTHR10814:SF21	TRANSDUCIN-LIKE ENHANCER PROTEIN 4
P04376	5HT4 type receptor mediated signaling pathway	P04426	K+ channel	RAT|RGD=621451|UniProtKB=Q9ES08	Potassium channel subfamily K member 9	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P04395	Vasopressin synthesis	P04590	Vasopressin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00018	EGF receptor signaling pathway	P00565	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	IDA	10851062	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04395	Vasopressin synthesis	P04596	Endo Peptidase	LEIMA|EnsemblGenome=LmjF.09.0770|UniProtKB=Q4QHU7	Oligopeptidase b	IC			PTHR11757:SF3	PROTEASE 2
P04380	Cortocotropin releasing factor receptor signaling pathway	G04671	proopiomelanocortin	BOVIN|Ensembl=ENSBTAG00000007897|UniProtKB=P01190	Pro-opiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00561	STAT	RAT|RGD=3774|UniProtKB=P52632	Signal transducer and activator of transcription 5B	IGI	96102059	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00036	Interleukin signaling pathway	P00968	Ikk	MACMU|Ensembl=ENSMMUG00000018476|UniProtKB=F6X938	Uncharacterized protein	ISS	14499113	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	DANRE|ZFIN=ZDB-GENE-030131-6206|UniProtKB=F1Q5K4	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF676	MYOSIN, HEAVY POLYPEPTIDE 2, FAST MUSCLE SPECIFIC
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	PANTR|Ensembl=ENSPTRG00000017042|UniProtKB=H2QR61	Dihydrofolate reductase	ISS			PTHR22778:SF39	DIHYDROFOLATE REDUCTASE
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00034	Integrin signalling pathway	P00951	Jnk	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04398	p53 pathway feedback loops 2	G04714	PTEN	TAKRU|Ensembl=ENSTRUG00000009851|UniProtKB=H2TJ90	Uncharacterized protein	IGI	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00048	PI3 kinase pathway	P01187	IR	CANLF|Ensembl=ENSCAFG00000018170|UniProtKB=E2RPM8	Tyrosine-protein kinase receptor	ISS	14500580	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P05913	Enkephalin release	P05972	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P06959	CCKR signaling map	P07079	p38MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	RCA	9003778	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	ORNAN|Ensembl=ENSOANG00000002061|UniProtKB=F7ANC6	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05913	Enkephalin release	P05978	AC	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	ISS	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05731	GABA-B receptor II signaling	P05753	Ca channel	RAT|RGD=628852|UniProtKB=Q02294	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	14507926	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00053	T cell activation	P01324	rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P02741	Flavin biosynthesis	P02939	Lumazine synthase	NEUCR|EnsemblGenome=EFNCRG00000009455|UniProtKB=Q7RVJ3	6,7-dimethyl-8-ribityllumazine synthase	ISS			PTHR21058:SF0	6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00007	Axon guidance mediated by semaphorins	P00339	CRMP	PANTR|Ensembl=ENSPTRG00000020099|UniProtKB=H2QVX6	Uncharacterized protein	ISS	7637782	PubMed	PTHR11647:SF56	DIHYDROPYRIMIDINASE-RELATED PROTEIN 2
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00045	Notch signaling pathway	P01099	Notch	RAT|RGD=620761|UniProtKB=Q9R172	Neurogenic locus notch homolog protein 3	ISS	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00017	DNA replication	P00536	DNA Topisomerase	BOVIN|Ensembl=ENSBTAG00000007960|UniProtKB=F1MN93	Uncharacterized protein	ISS			PTHR10290:SF5	DNA TOPOISOMERASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	TAS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	15313841	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P04393	Ras Pathway	P04558	p38	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	IDA	8920915	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	IDA	10514528	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00059	p53 pathway	P01486	Akt	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	TAS	12089061	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00054	Toll receptor signaling pathway	P01360	IKKbeta	CANLF|Ensembl=ENSCAFG00000005526|UniProtKB=E2RKR0	Uncharacterized protein	ISS	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00049	Parkinson disease	P01208	Hsp70	TAKRU|Ensembl=ENSTRUG00000015162|UniProtKB=H2UP56	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF310	HEAT SHOCK COGNATE 71 KDA PROTEIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	DANRE|ZFIN=ZDB-GENE-030131-9662|UniProtKB=Q6TEN1	Ras-related protein Rap-1b	ISS	8576107	PubMed	PTHR24070:SF382	RAS-RELATED PROTEIN RAP-1B
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04633	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00561	STAT	MACMU|Ensembl=ENSMMUG00000010707|UniProtKB=F7G8G5	Signal transducer and activator of transcription	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00052	TGF-beta signaling pathway	P01275	P38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00034	Integrin signalling pathway	P00941	Integrin alpha	MOUSE|MGI=MGI=109442|UniProtKB=A2ARA8	Integrin alpha-8	IPI	10778855	PubMed	PTHR23220:SF5	INTEGRIN ALPHA-8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IDA	8787761	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00010	B cell activation	P00371	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	HUMAN|HGNC=8590|UniProtKB=Q13153	Serine/threonine-protein kinase PAK 1	ISS	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00021	FGF signaling pathway	P00628	JNK1-3	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IGI	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00029	Huntington disease	P00778	NMDA receptor	MOUSE|MGI=MGI=1933206|UniProtKB=A2AIR5	Protein Grin3a	ISS	14698601	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00046	Oxidative stress response	P01122	TRX	DICDI|dictyBase=DDB_G0276057|UniProtKB=Q75JM6	Uncharacterized protein	TAS			PTHR10438:SF284	THIOREDOXIN-LIKE PROTEIN 1
P00046	Oxidative stress response	P01133	Max	DROME|FlyBase=FBgn0017578|UniProtKB=P91664	Protein max	TAS	11274345	PubMed	PTHR10328:SF3	PROTEIN MAX
P00018	EGF receptor signaling pathway	P00564	Rac	ARATH|TAIR=AT1G20090|UniProtKB=Q38919	Rac-like GTP-binding protein ARAC4	ISS			PTHR24072:SF194	RAC-LIKE GTP-BINDING PROTEIN ARAC4-RELATED
P00057	Wnt signaling pathway	P01428	Frizzled	PANTR|Ensembl=ENSPTRG00000012813|UniProtKB=H2QJ90	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF31	FRIZZLED-7
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	ORNAN|Ensembl=ENSOANG00000006811|UniProtKB=F6WBD5	Uncharacterized protein	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MOUSE|MGI=MGI=2155600|UniProtKB=Q91Z83	Myosin-7	IEP	10938134	PubMed	PTHR13140:SF344	MYOSIN-7
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	THEMA|EnsemblGenome=TM_0118|UniProtKB=G4FH33	Ribonucleotide reductase of class II (Coenzyme B12-dependent)	ISS			PTHR43371:SF1	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	RAT|RGD=71027|UniProtKB=P42264	Glutamate receptor ionotropic, kainate 3	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P02724	Alanine biosynthesis	P02815	Branched chain amino acid aminotransferase	YEAST|SGD=S000003909|UniProtKB=P47176	Branched-chain-amino-acid aminotransferase, cytosolic	ISS			PTHR11825:SF44	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P00050	Plasminogen activating cascade	P01263	pro-MMP-1	PANTR|Ensembl=ENSPTRG00000023318|UniProtKB=H2Q4N3	Matrix metallopeptidase 1 (Interstitial collagenase)	ISS	12834808	PubMed	PTHR10201:SF151	INTERSTITIAL COLLAGENASE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=1915409|UniProtKB=Q8R1Q0	Syntaxin-19	ISS	11067767	PubMed	PTHR19957:SF29	SYNTAXIN-19
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	TAS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ANOGA|EnsemblGenome=AGAP005913|UniProtKB=Q7Q6D2	AGAP005913-PA	IC	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	STRPU|EnsemblGenome=SPU_012282|UniProtKB=W4Y969	Uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF369	ACTIN-42A
P05918	p38 MAPK pathway	P06035	TAB1	CANLF|Ensembl=ENSCAFG00000001332|UniProtKB=F1PLP7	Uncharacterized protein	ISS	8638164	PubMed	PTHR13832:SF533	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	G04714	PTEN	MOUSE|MGI=MGI=2446460|UniProtKB=G5E8H5	MCG118205, isoform CRA_c	IGI			PTHR12305:SF32	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE TPTE2-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	LEIMA|EnsemblGenome=LmjF.35.3960|UniProtKB=E9AFM1	Protein kinase A catalytic subunit isoform 2	IC	14744463	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00053	T cell activation	P01322	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00034	Integrin signalling pathway	P00924	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	YEAST|SGD=S000004219|UniProtKB=P19073	Cell division control protein 42	ISS	12932731	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00052	TGF-beta signaling pathway	P01288	FKBP12	TETTS|EnsemblGenome=TTHERM_00227040|UniProtKB=Q23BX8	Peptidyl-prolyl cis-trans isomerase	TAS			PTHR10516:SF341	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00029	Huntington disease	P00807	Actin	DICDI|dictyBase=DDB_G0289489|UniProtKB=P07828	Actin-18	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	ORNAN|Ensembl=ENSOANG00000007405|UniProtKB=F7CIV4	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	CANLF|Ensembl=ENSCAFG00000017040|UniProtKB=E2QYK5	Uncharacterized protein	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00018	EGF receptor signaling pathway	P00543	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	8946911	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	ARATH|TAIR=AT1G13890|UniProtKB=Q9LMG8	Putative SNAP25 homologous protein SNAP30	IC			PTHR19305:SF7	SNAP25 HOMOLOGOUS PROTEIN SNAP30-RELATED
P00018	EGF receptor signaling pathway	P00551	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IGI	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05915	Opioid proenkephalin pathway	P05991	Enkephalin	DANRE|ZFIN=ZDB-GENE-030729-3|UniProtKB=F1QTD1	Uncharacterized protein (Fragment)	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00005	Angiogenesis	P00252	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	4504111	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00005	Angiogenesis	P00237	FRP	HUMAN|HGNC=10776|UniProtKB=Q8N474	Secreted frizzled-related protein 1	ISS	9096311	PubMed	PTHR11309:SF87	SECRETED FRIZZLED-RELATED PROTEIN 1
P00029	Huntington disease	P00807	Actin	CHICK|Ensembl=ENSGALG00000009621|UniProtKB=P60706	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00054	Toll receptor signaling pathway	P01352	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00034	Integrin signalling pathway	P00927	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00057	Wnt signaling pathway	P01451	Galpha	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	IDA	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00018	EGF receptor signaling pathway	P00565	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IGI	10644715	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000025373|UniProtKB=F6ZZG9	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00030	Hypoxia response via HIF activation	P00823	PI3K	CAEEL|WormBase=WBGene00006932|UniProtKB=Q9TXI7	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	21924698	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IGI	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02787	Vitamin B6 metabolism	P03236	Pyridoxamine phosphate oxidase	CANLF|Ensembl=ENSCAFG00000016814|UniProtKB=E2QTE2	Uncharacterized protein	ISS	9601034	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00021	FGF signaling pathway	P00629	PP2A	HUMAN|HGNC=9311|UniProtKB=Q13362	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	ISS	10092233	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00046	Oxidative stress response	P01129	JNK1/2	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00589	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02788	Xanthine and guanine salvage pathway	P03247	Xanthine phosphoribosyl transferase	ORNAN|Ensembl=ENSOANG00000011689|UniProtKB=F7AT83	Uncharacterized protein	ISS			PTHR43340:SF6	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P02728	Arginine biosynthesis	P02847	N-actetylornithine deacetylase	BACSU|EnsemblGenome=BSU15350|UniProtKB=O31724	N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine deformylase	ISS			PTHR43325:SF2	SUBFAMILY NOT NAMED
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	DICDI|dictyBase=DDB_G0285429|UniProtKB=P21900	Adenylosuccinate synthetase	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	BOVIN|Ensembl=ENSBTAG00000007909|UniProtKB=F1MPE9	Uncharacterized protein	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P06664	Gonadotropin-releasing hormone receptor pathway	P06841	gnaq/11	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	RCA	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	ANOGA|EnsemblGenome=AGAP003424|UniProtKB=Q7QDI9	AGAP003424-PA	TAS	9362521	PubMed	PTHR18914:SF9	CATENIN ALPHA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	PHYPA|Gene=PHYPADRAFT_210000|UniProtKB=A9S9L5	Predicted protein	ISS	10487978	PubMed	PTHR23050:SF245	AT16150P-RELATED
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	MOUSE|MGI=MGI=88017|UniProtKB=Q91X83	S-adenosylmethionine synthase isoform type-1	ISS			PTHR11964:SF11	S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-1
P04375	5HT3 type receptor mediated signaling pathway	P04425	K+ channel	HUMAN|HGNC=6283|UniProtKB=Q9NPC2	Potassium channel subfamily K member 9	ISS	15282272	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00050	Plasminogen activating cascade	P01253	Fibrin	PANTR|Ensembl=ENSPTRG00000016534|UniProtKB=H2QQB4	Uncharacterized protein	ISS	11761631	gi	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00036	Interleukin signaling pathway	P00990	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00211	GSK3beta	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IDA	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00024	Glycolysis	P00679	Aldolase	MACMU|Ensembl=ENSMMUG00000000983|UniProtKB=F6SYL4	Fructose-bisphosphate aldolase	ISS	84261525	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P02738	De novo purine biosynthesis	P02907	dADP kinase	DROME|FlyBase=FBgn0030573|UniProtKB=Q9VY27	Nucleoside diphosphate kinase	ISS			PTHR11349:SF70	NUCLEOSIDE DIPHOSPHATE KINASE 6
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04393	Ras Pathway	P04542	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MONDO|Ensembl=ENSMODG00000007194|UniProtKB=F6X9N6	Actin-related protein 2/3 complex subunit 5	ISS	9230079	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00009	Axon guidance mediated by netrin	P00363	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	ISS	12660731	PubMed	PTHR10048:SF14	PI-3 KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CRYNJ|EnsemblGenome=CNA04650|UniProtKB=Q5KP06	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00049	Parkinson disease	P01241	TH	TAKRU|Ensembl=ENSTRUG00000009267|UniProtKB=A0JGX6	Tyrosine 3-monooxygenase	TAS	12814656	PubMed	PTHR11473:SF34	TYROSINE HYDROXYLASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MACMU|Ensembl=ENSMMUG00000017237|UniProtKB=F7HBZ1	Regulator of G-protein signaling 2	ISS	8756726	PubMed	PTHR10845:SF43	REGULATOR OF G-PROTEIN SIGNALING 2
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	HUMAN|HGNC=6698|UniProtKB=O75581	Low-density lipoprotein receptor-related protein 6	IDA	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00557	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	IGI	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00048	PI3 kinase pathway	P01179	PKB	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00572	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00056	VEGF signaling pathway	P01423	p38MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00059	p53 pathway	P04633	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00054	Toll receptor signaling pathway	P01350	TIRAP	HUMAN|HGNC=17192|UniProtKB=P58753	Toll/interleukin-1 receptor domain-containing adapter protein	RCA			PTHR22662:SF0	TOLL/INTERLEUKIN-1 RECEPTOR DOMAIN-CONTAINING ADAPTER PROTEIN
P00034	Integrin signalling pathway	P00922	Collagen	PANTR|Ensembl=ENSPTRG00000018524|UniProtKB=H2QTL5	Collagen, type X, alpha 1	ISS	10778855	PubMed	PTHR44057:SF5	COLLAGEN ALPHA-1 X  CHAIN
P00038	JAK/STAT signaling pathway	P01027	STAT	MONDO|Ensembl=ENSMODG00000028212|UniProtKB=F7BYN4	Signal transducer and activator of transcription	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95816|UniProtKB=B1AS29	Glutamate receptor ionotropic, kainate 3	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000007909|UniProtKB=F1MPE9	Uncharacterized protein	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IDA	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01192	p110	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00014	Cholesterol biosynthesis	P00500	Phosphomevalonate kinase	HUMAN|HGNC=9141|UniProtKB=Q15126	Phosphomevalonate kinase	ISS			PTHR13101:SF1	PHOSPHOMEVALONATE KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MOUSE|MGI=MGI=102522|UniProtKB=Q8R3Z5	Voltage-dependent L-type calcium channel subunit beta-1	IC	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00010	B cell activation	P00376	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IDA	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P00005	Angiogenesis	P00211	GSK3beta	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00012	Cadherin signaling pathway	P00465	TCF/LEF	MOUSE|MGI=MGI=1202876|UniProtKB=Q9Z1J1	Transcription factor 7-like 1	ISS	9118222	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MACMU|Ensembl=ENSMMUG00000001353|UniProtKB=F7D6T8	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00302	ATF	CANLF|Ensembl=ENSCAFG00000013332|UniProtKB=F1PCQ4	Uncharacterized protein	ISS	10487205	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PANTR|Ensembl=ENSPTRG00000024071|UniProtKB=H2R221	Uncharacterized protein	ISS			PTHR13140:SF345	UNCONVENTIONAL MYOSIN-XVI
P05913	Enkephalin release	P05974	G-Protein (i)	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IC	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00559	MEK1-2	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PANTR|Ensembl=ENSPTRG00000017939|UniProtKB=Q7JJU6	Tubulin beta chain	ISS	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00053	T cell activation	P01309	fos	RAT|RGD=2626|UniProtKB=P12841	Proto-oncogene c-Fos	TAS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PHYPA|Gene=PHYPADRAFT_107830|UniProtKB=A9TBG2	Actin 7	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00047	PDGF signaling pathway	P01159	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00052	TGF-beta signaling pathway	P01275	P38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	PANTR|Ensembl=ENSPTRG00000012508|UniProtKB=H2QIS5	Uncharacterized protein	ISS	11907044	PubMed	PTHR44025:SF7	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	TAS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00636	FGFR1-4	MOUSE|MGI=MGI=95523|UniProtKB=P21803	Fibroblast growth factor receptor 2	IGI	1373495	PubMed	PTHR24416:SF130	FIBROBLAST GROWTH FACTOR RECEPTOR 2
P00034	Integrin signalling pathway	P00920	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MONDO|Ensembl=ENSMODG00000015573|UniProtKB=F7AIP6	Uncharacterized protein (Fragment)	ISS	11266476	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	RAT|RGD=2733|UniProtKB=P42260	Glutamate receptor ionotropic, kainate 2	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00047	PDGF signaling pathway	P01175	Shc	PANTR|Ensembl=ENSPTRG00000021091|UniProtKB=H2QXF3	Uncharacterized protein	ISS	98175964	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00561	STAT	BOVIN|Gene=STAT3|UniProtKB=P61635	Signal transducer and activator of transcription 3	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00048	PI3 kinase pathway	P01179	PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	CAEEL|WormBase=WBGene00000552|UniProtKB=O16305	Calmodulin	ISS			PTHR23050:SF236	CALMODULIN
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02747	Histidine biosynthesis	P02988	Histidinal dehydrogenase	GLOVI|EnsemblGenome=BAC89265|UniProtKB=Q7NL02	Histidinol dehydrogenase	ISS			PTHR21256:SF2	HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	176910	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00556	PLCgamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00056	VEGF signaling pathway	P01425	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00839	SHIP	BOVIN|Ensembl=ENSBTAG00000019167|UniProtKB=E1BBJ7	Uncharacterized protein	ISS	9824312	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00018	EGF receptor signaling pathway	P00546	GAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	8270251	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00029	Huntington disease	P00807	Actin	TAKRU|Ensembl=ENSTRUG00000007989|UniProtKB=P68140	Actin, alpha skeletal muscle A	IDA	11889126	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00054	Toll receptor signaling pathway	P01377	MyD88	MACMU|Ensembl=ENSMMUG00000000995|UniProtKB=B3Y683	Myeloid differentiation primary response protein MyD88	ISS			PTHR15079:SF3	MYELOID DIFFERENTIATION PRIMARY RESPONSE PROTEIN MYD88
P00012	Cadherin signaling pathway	P00475	Frizzled	MACMU|Ensembl=ENSMMUG00000022114|UniProtKB=F7H7V5	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF81	FRIZZLED-1
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00036	Interleukin signaling pathway	P00965	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00034	Integrin signalling pathway	P00916	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IPI	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	BOVIN|Ensembl=ENSBTAG00000014614|UniProtKB=P62739	Actin, aortic smooth muscle	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00023	General transcription regulation	P00668	TFIIB	PANTR|Ensembl=ENSPTRG00000008174|UniProtKB=H2QB82	Chromosome 16 open reading frame 80	ISS			PTHR12458:SF8	CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00059	p53 pathway	G04697	B99	HUMAN|HGNC=13698|UniProtKB=Q9NYZ3	G2 and S phase-expressed protein 1	TAS	12750368	PubMed	PTHR21584:SF10	G2 AND S PHASE-EXPRESSED PROTEIN 1
P00047	PDGF signaling pathway	P01154	Ras	DICPU|Gene=DICPUDRAFT_91367|UniProtKB=F0ZB76	Putative uncharacterized protein rasD	ISS	6091907	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	BOVIN|Gene=MMP1|UniProtKB=P28053	Interstitial collagenase	TAS	95201294	PubMed	PTHR10201:SF151	INTERSTITIAL COLLAGENASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MONDO|Ensembl=ENSMODG00000005623|UniProtKB=F7CFG8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00057	Wnt signaling pathway	P01455	Smad4	HUMAN|HGNC=6770|UniProtKB=Q13485	Mothers against decapentaplegic homolog 4	IDA	9395284	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MOUSE|MGI=MGI=88398|UniProtKB=Q9ERZ3	Muscarinic acetylcholine receptor M3	TAS	12915051	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	PANTR|Ensembl=ENSPTRG00000019361|UniProtKB=H2QUV3	Uncharacterized protein	ISS			PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00036	Interleukin signaling pathway	P00983	Raf	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DICDI|dictyBase=DDB_G0277143|UniProtKB=P36408	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00840	GPRK	DROME|FlyBase=FBgn0261988|UniProtKB=P32866	G protein-coupled receptor kinase 2	IDA	10085131	PubMed	PTHR24355:SF28	G PROTEIN-COUPLED RECEPTOR KINASE 2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00114	actin	YARLI|EnsemblGenome=YALI0_D08272g|UniProtKB=Q9UVF3	Actin	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00057	Wnt signaling pathway	P01469	Dapper	RAT|RGD=1564008|UniProtKB=D4A3W8	Protein Dact1	ISS	11970895	PubMed	PTHR15919:SF12	DAPPER HOMOLOG 1
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	MOUSE|MGI=MGI=94925|UniProtKB=P30728	D(3) dopamine receptor	RCA	1319557	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P05913	Enkephalin release	G06045	preproenkephalin	PANTR|Ensembl=ENSPTRG00000013172|UniProtKB=H2QJT9	Uncharacterized protein	ISS	131330	OMIM	PTHR11438:SF4	PROENKEPHALIN-B
P00018	EGF receptor signaling pathway	P00563	Gab	PANTR|Ensembl=ENSPTRG00000015207|UniProtKB=H2RB91	Pleckstrin homology-like domain, family B, member 2	ISS			PTHR12156:SF21	PLECKSTRIN HOMOLOGY-LIKE DOMAIN FAMILY B MEMBER 2
P00019	Endothelin signaling pathway	P00566	ERK	ARATH|TAIR=AT4G01370|UniProtKB=Q39024	Mitogen-activated protein kinase 4	ISS			PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MOUSE|MGI=MGI=107182|UniProtKB=P51682	C-C chemokine receptor type 5	ISS			PTHR10489:SF686	C-C CHEMOKINE RECEPTOR TYPE 5
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	DANRE|ZFIN=ZDB-GENE-040822-37|UniProtKB=Q68EH2	Adenylate kinase isoenzyme 1	ISS			PTHR23359:SF59	ADENYLATE KINASE ISOENZYME 1
P00047	PDGF signaling pathway	P01153	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00030	Hypoxia response via HIF activation	P00818	HIF-1alpha	RAT|RGD=61928|UniProtKB=O35800	Hypoxia-inducible factor 1-alpha	TAS	14526383	PubMed	PTHR23043:SF7	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00890	ELK	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	9644975	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00034	Integrin signalling pathway	P00923	Arf1	RAT|RGD=621326|UniProtKB=P61212	ADP-ribosylation factor-like protein 1	IPI	12932731	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	HUMAN|HGNC=1402|UniProtKB=Q08289	Voltage-dependent L-type calcium channel subunit beta-2	ISS	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00644	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00012	Cadherin signaling pathway	P00475	Frizzled	DANRE|ZFIN=ZDB-GENE-990415-229|UniProtKB=Q8QFM3	Frizzled 7a	IDA	8717036	PubMed	PTHR11309:SF31	FRIZZLED-7
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONBE|Gene=37852|UniProtKB=A9V489	Predicted protein	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00005	Angiogenesis	P00249	PAK	RAT|RGD=3251|UniProtKB=Q62829	Serine/threonine-protein kinase PAK 3	ISS	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00019	Endothelin signaling pathway	P00566	ERK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	NAS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04393	Ras Pathway	P04569	Cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000002339|UniProtKB=H2R368	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05913	Enkephalin release	P05974	G-Protein (i)	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04393	Ras Pathway	P04579	Shc	MOUSE|MGI=MGI=98296|UniProtKB=P98083	SHC-transforming protein 1	IDA	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00029	Huntington disease	P00780	Microtubule	DICPU|Gene=DICPUDRAFT_47166|UniProtKB=F0ZI20	Beta tubulin	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00034	Integrin signalling pathway	P00920	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	CHICK|Ensembl=ENSGALG00000003820|UniProtKB=E1C8Y3	Actin-related protein 2/3 complex subunit 3	ISS	12473693	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P02742	Tetrahydrofolate biosynthesis	P02944	Phosphoribosylglycinamide formyltransferase	SCHPO|PomBase=SPCC569.08c|UniProtKB=Q9UUK7	Phosphoribosylglycinamide formyltransferase	ISS			PTHR43369:SF2	PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE
P00046	Oxidative stress response	P01131	MKP5	PANTR|Ensembl=ENSPTRG00000041351|UniProtKB=H2RH74	Uncharacterized protein	ISS			PTHR10159:SF386	DUAL SPECIFICITY PROTEIN PHOSPHATASE 21
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00058	mRNA splicing	P01473	U6	MOUSE|MGI=MGI=1918017|UniProtKB=Q922U1	U4/U6 small nuclear ribonucleoprotein Prp3	ISS	9328476	PubMed	PTHR14212:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01168	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00057	Wnt signaling pathway	P01465	Ggamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00010	B cell activation	P00398	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00059	p53 pathway	G04694	p110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000005238|UniProtKB=F7BWT2	Uncharacterized protein	ISS	12441358	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00046	Oxidative stress response	P01134	cPLA2	PANTR|Ensembl=ENSPTRG00000001787|UniProtKB=H2Q0T0	Phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	HUMAN|HGNC=9509|UniProtKB=P49810	Presenilin-2	IDA	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00012	Cadherin signaling pathway	P00474	Wnt	MACMU|Ensembl=ENSMMUG00000009980|UniProtKB=F6R3A1	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	SULSO|EnsemblGenome=SSO2863|UniProtKB=Q97UX8	Acetyl-CoA synthetase (Acetate-CoA ligase) (AcsA-9)	ISS			PTHR24095:SF232	SUBFAMILY NOT NAMED
P00012	Cadherin signaling pathway	P00470	F-actin	CAEEL|WormBase=WBGene00000067|UniProtKB=O45815	ACTin	IC	14684598	PubMed	PTHR11937:SF352	ACTIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	IDA	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PANTR|Ensembl=ENSPTRG00000017675|UniProtKB=H2QS81	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	PANTR|Ensembl=ENSPTRG00000007514|UniProtKB=H2R439	Uncharacterized protein	ISS			PTHR42884:SF8	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 6
P02772	Pyruvate metabolism	P03137	Citrate Lyase	MONDO|Ensembl=ENSMODG00000014738|UniProtKB=F6ZC40	ATP-citrate synthase	ISS			PTHR23118:SF0	ATP-CITRATE SYNTHASE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00034	Integrin signalling pathway	P00920	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00817	TOR	CHICK|Ensembl=ENSGALG00000003339|UniProtKB=F1NUX4	Uncharacterized protein	ISS	8662507	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00021	FGF signaling pathway	P00631	Grb2	HUMAN|HGNC=4562|UniProtKB=Q13588	GRB2-related adapter protein	ISS	51702266	gi	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P00012	Cadherin signaling pathway	P00475	Frizzled	MOUSE|MGI=MGI=1196625|UniProtKB=O70421	Frizzled-1	IDA	12549854	PubMed	PTHR11309:SF81	FRIZZLED-1
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00149	Pen-2	DANRE|ZFIN=ZDB-GENE-040218-1|UniProtKB=Q8JHF0	Gamma-secretase subunit PEN-2	ISS	12110170	PubMed	PTHR16318:SF0	GAMMA-SECRETASE SUBUNIT PEN-2
P06664	Gonadotropin-releasing hormone receptor pathway	G06671	Follistatin	MOUSE|MGI=MGI=95586|UniProtKB=P47931	Follistatin	RCA			PTHR10913:SF6	FOLLISTATIN
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	BOVIN|Gene=DRD2|UniProtKB=P20288	D(2) dopamine receptor	ISS	11248120	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P04398	p53 pathway feedback loops 2	P04661	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01438	PP2A	MOUSE|MGI=MGI=1321161|UniProtKB=P62715	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00572	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=11433|UniProtKB=Q16623	Syntaxin-1A	ISS	1321498	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00057	Wnt signaling pathway	P01457	GBeta	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	CHICK|Gene=IGF2|UniProtKB=P33717	Insulin-like growth factor II	ISS	4504609	gi	PTHR11454:SF10	INSULIN-LIKE GROWTH FACTOR II
P00056	VEGF signaling pathway	P01408	Akt/PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00475	Frizzled	PANTR|Ensembl=ENSPTRG00000020490|UniProtKB=H2R2C6	Frizzled homolog 6	ISS	11212302	PubMed	PTHR11309:SF75	FRIZZLED-6
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P06587	Nicotine pharmacodynamics pathway	P06605	KCNK3/9	MONDO|Ensembl=ENSMODG00000015769|UniProtKB=F6ZSC2	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00019	Endothelin signaling pathway	P00589	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01242	Casein kinase I	XENTR|Xenbase=XB-GENE-478121|UniProtKB=F6VPH2	Uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=1930705|UniProtKB=P61264	Syntaxin-1B	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00036	Interleukin signaling pathway	P00970	Interleukin	CANLF|Gene=IL10|UniProtKB=P48411	Interleukin-10	IDA	8746793	PubMed	PTHR44875:SF1	INTERLEUKIN-10
P00053	T cell activation	P01332	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00923	Arf1	MOUSE|MGI=MGI=99436|UniProtKB=P61211	ADP-ribosylation factor-like protein 1	ISS	12932731	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P00047	PDGF signaling pathway	P01142	p90RSK	CANLF|Ensembl=ENSCAFG00000017679|UniProtKB=E2RMD8	Ribosomal protein S6 kinase	ISS	15116068	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00057	Wnt signaling pathway	P01456	beta-arrestin	PANTR|Ensembl=ENSPTRG00000008601|UniProtKB=H2QBY1	Arrestin, beta 2	ISS	9388255	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MOUSE|MGI=MGI=1339712|UniProtKB=P13542	Myosin-8	ISS	10938134	PubMed	PTHR13140:SF368	MYOSIN-8
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00048	PI3 kinase pathway	P01178	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	7689150	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00019	Endothelin signaling pathway	P00566	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00251	cPLA2	PANTR|Ensembl=ENSPTRG00000006969|UniProtKB=H2Q989	Phospholipase A2	ISS			PTHR10728:SF31	CYTOSOLIC PHOSPHOLIPASE A2 DELTA
P00036	Interleukin signaling pathway	P00976	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IPI	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05731	GABA-B receptor II signaling	P05752	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IC	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00053	T cell activation	P01312	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	MOUSE|MGI=MGI=1201670|UniProtKB=O35226	26S proteasome non-ATPase regulatory subunit 4	ISS	11827521	PubMed	PTHR10223:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	DANRE|ZFIN=ZDB-GENE-020125-5|UniProtKB=A2CG69	Uncharacterized protein	ISS	20112749	PubMed	PTHR18966:SF356	SUBFAMILY NOT NAMED
P05915	Opioid proenkephalin pathway	P05989	leu-Enkephalin	BOVIN|Ensembl=ENSBTAG00000004924|UniProtKB=P01211	Proenkephalin-A	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	PANTR|Ensembl=ENSPTRG00000003554|UniProtKB=H2Q3I3	Low density lipoprotein receptor-related protein 4	ISS	11907044	PubMed	PTHR44017:SF4	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8664|UniProtKB=Q9Y5I2	Protocadherin alpha-10	IDA	8120095	PubMed	PTHR24028:SF124	PROTOCADHERIN ALPHA-10
P00029	Huntington disease	P00786	ARF	DAPPU|EnsemblGenome=DAPPUDRAFT_231341|UniProtKB=E9H3D5	Putative uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF304	ADP-RIBOSYLATION FACTOR 1
P06959	CCKR signaling map	P07209	TPC1/2	HUMAN|HGNC=20820|UniProtKB=Q8NHX9	Two pore calcium channel protein 2	RCA	19387438	PubMed	PTHR10037:SF92	TWO PORE CALCIUM CHANNEL PROTEIN 2
P00059	p53 pathway	G01579	PTEN	ARATH|TAIR=AT3G19420|UniProtKB=Q9LT75	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN2A	ISS			PTHR12305:SF32	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE TPTE2-RELATED
P00052	TGF-beta signaling pathway	P01286	TGFbeta	CHICK|Ensembl=ENSGALG00000004742|UniProtKB=F1NHC3	Uncharacterized protein	TAS	9759503	PubMed	PTHR11848:SF22	BONE MORPHOGENETIC PROTEIN 15
P00053	T cell activation	P01309	fos	RAT|RGD=2626|UniProtKB=P12841	Proto-oncogene c-Fos	TAS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04397	p53 pathway by glucose deprivation	P04644	TSC2	RAT|RGD=3908|UniProtKB=P49816	Tuberin	IDA	15249583	PubMed	PTHR10063:SF0	TUBERIN
P00029	Huntington disease	P00807	Actin	STRPU|EnsemblGenome=SPU_026078|UniProtKB=W4ZD41	Uncharacterized protein	IDA	10974003	PubMed	PTHR11937:SF277	SUBFAMILY NOT NAMED
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02747	Histidine biosynthesis	P02991	Histidinephosphate aminotransferase	METJA|EnsemblGenome=MJ_0955|UniProtKB=Q58365	Histidinol-phosphate aminotransferase	ISS			PTHR42885:SF2	HISTIDINOL-PHOSPHATE AMINOTRANSFERASE
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	CHICK|Ensembl=ENSGALG00000007509|UniProtKB=F1NM72	Uncharacterized protein	ISS	6309844	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00047	PDGF signaling pathway	P01163	c-Jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=98961|UniProtKB=P24383	Protein Wnt-7a	IDA	12549854	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00006	Apoptosis signaling pathway	P00291	MEKK1	RAT|RGD=620966|UniProtKB=Q62925	Mitogen-activated protein kinase kinase kinase 1	ISS	8643568	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00005	Angiogenesis	P00211	GSK3beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	HUMAN|HGNC=9991|UniProtKB=Q08116	Regulator of G-protein signaling 1	IDA	8756726	PubMed	PTHR10845:SF34	REGULATOR OF G-PROTEIN SIGNALING 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	LEIMA|EnsemblGenome=LmjF.35.3960|UniProtKB=E9AFM1	Protein kinase A catalytic subunit isoform 2	ISS	14744463	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000005727|UniProtKB=F6TQT6	Uncharacterized protein	ISS	10644715	PubMed	PTHR24356:SF246	SERINE/THREONINE-PROTEIN KINASE N1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00729	Goalpha	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	ISS	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=12781|UniProtKB=Q93097	Protein Wnt-2b	IDA	11266476	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DROME|FlyBase=FBgn0014011|UniProtKB=P48554	Ras-related protein Rac2	ISS	4757952	gi	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P04398	p53 pathway feedback loops 2	P04662	cyclin G	BOVIN|Ensembl=ENSBTAG00000006607|UniProtKB=Q5E9I1	Cyclin-G1	ISS	12556559	PubMed	PTHR10177:SF59	CYCLIN-G1
P00018	EGF receptor signaling pathway	P00563	Gab	BOVIN|Ensembl=ENSBTAG00000002922|UniProtKB=F1MFX6	Uncharacterized protein	ISS	18105042	gi	PTHR12156:SF4	GRB2-ASSOCIATED-BINDING PROTEIN 2
P00005	Angiogenesis	P00254	GTPase	MONDO|Ensembl=ENSMODG00000012981|UniProtKB=F7CS91	Uncharacterized protein	ISS	15668138	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	MOUSE|MGI=MGI=96575|UniProtKB=P15208	Insulin receptor	TAS	2983222	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	HUMAN|HGNC=10935|UniProtKB=Q05940	Synaptic vesicular amine transporter	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00021	FGF signaling pathway	P00632	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	IGI	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02749	Leucine biosynthesis	P03002	Isopropylmalate isomerase	METAC|EnsemblGenome=MA_1393|UniProtKB=Q8TQZ3	Probable 3-isopropylmalate dehydratase large subunit	ISS			PTHR43822:SF2	HOMOACONITASE, MITOCHONDRIAL
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	12855688	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00057	Wnt signaling pathway	P01435	SWI/SNF	RAT|RGD=1311935|UniProtKB=D4ACG6	Protein Chd1l	ISS	11532957	PubMed	PTHR10799:SF949	CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1-LIKE
P00009	Axon guidance mediated by netrin	P00364	cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00004	Alzheimer disease-presenilin pathway	P00148	Erb-B4 N-terminal fragment	MONDO|Ensembl=ENSMODG00000015755|UniProtKB=F6ZSZ9	Uncharacterized protein (Fragment)	ISS	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00021	FGF signaling pathway	P00644	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	ISS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00018	EGF receptor signaling pathway	P00546	GAP	MACMU|Ensembl=ENSMMUG00000008605|UniProtKB=F6UAM4	Uncharacterized protein	ISS	95047432	PubMed	PTHR10194:SF60	NEUROFIBROMIN
P00049	Parkinson disease	P01236	Casein kinase II	ANOGA|EnsemblGenome=AGAP005569|UniProtKB=Q7Q707	AGAP005569-PA	ISS	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00021	FGF signaling pathway	P00632	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05918	p38 MAPK pathway	P06015	p38gamma	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	RCA	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00036	Interleukin signaling pathway	P00990	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00238	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	IXOSC|EnsemblGenome=ISCW017136|UniProtKB=B7PA95	Beta tubulin	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=101848|UniProtKB=P62881	Guanine nucleotide-binding protein subunit beta-5	IC	11313908	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00034	Integrin signalling pathway	P00907	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	IDA	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00020	FAS signaling pathway	P00601	c-Jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	RAT|RGD=2917|UniProtKB=P15127	Insulin receptor	ISS	2983222	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P00047	PDGF signaling pathway	P01162	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00005	Angiogenesis	P00182	p38MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	HUMAN|HGNC=6857|UniProtKB=Q99683	Mitogen-activated protein kinase kinase kinase 5	IGI	12697749	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CANLF|Ensembl=ENSCAFG00000002617|UniProtKB=E2QUL1	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00019	Endothelin signaling pathway	P00568	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	11554554	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	8787761	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT1G59580|UniProtKB=Q39022	Mitogen-activated protein kinase 2	ISS	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	HALSA|EnsemblGenome=VNG_1001G|UniProtKB=Q9HQU4	Inosine-5'-monophosphate dehydrogenase	ISS			PTHR11911:SF6	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE
P00035	Interferon-gamma signaling pathway	P00958	PIAS	XENTR|Xenbase=XB-GENE-486558|UniProtKB=F6YUL3	Uncharacterized protein (Fragment)	ISS	8682149	PubMed	PTHR10782:SF11	E3 SUMO-PROTEIN LIGASE PIAS1
P00049	Parkinson disease	P01211	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00221	JNK1	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	RCA	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	PANTR|Ensembl=ENSPTRG00000000599|UniProtKB=H2PYS9	CTP synthase	ISS			PTHR11550:SF8	CTP SYNTHASE 1
P00030	Hypoxia response via HIF activation	P00817	TOR	HUMAN|HGNC=3942|UniProtKB=P42345	Serine/threonine-protein kinase mTOR	TAS	8662507	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P04393	Ras Pathway	P04567	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04623	CBP	ARATH|TAIR=AT1G67220|UniProtKB=Q9FYH1	Histone acetyltransferase HAC2	IDA	10823891	PubMed	PTHR13808:SF6	HISTONE ACETYLTRANSFERASE HAC2
P00021	FGF signaling pathway	P00645	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00021	FGF signaling pathway	P00627	ERK1-2	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00260	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00025	Hedgehog signaling pathway	P00697	Sap18	CAEEL|WormBase=WBGene00007625|UniProtKB=Q09250	Probable histone deacetylase complex subunit SAP18	ISS			PTHR13082:SF0	HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18
P00047	PDGF signaling pathway	P01150	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00046	Oxidative stress response	P01135	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00019	Endothelin signaling pathway	P00585	ECE1-3	MACMU|Ensembl=ENSMMUG00000010942|UniProtKB=F7GIX6	Uncharacterized protein	ISS	94340737	PubMed	PTHR11733:SF130	ENDOTHELIN-CONVERTING ENZYME 1
P04393	Ras Pathway	P04541	p90RSK	MACMU|Ensembl=ENSMMUG00000022111|UniProtKB=F7H7W3	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ARATH|TAIR=AT5G59370|UniProtKB=P53494	Actin-4	IC	11889126	PubMed	PTHR11937:SF366	ACTIN-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00864	MEK	RAT|RGD=1311192|UniProtKB=A0A0G2K3R1	Protein Map3k4	ISS			PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00034	Integrin signalling pathway	P00951	Jnk	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00019	Endothelin signaling pathway	P00587	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00810	GAPDH	CRYNJ|EnsemblGenome=CNF03160|UniProtKB=P0CN74	Glyceraldehyde-3-phosphate dehydrogenase	IPI			PTHR10836:SF52	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MOUSE|MGI=MGI=1343142|UniProtKB=Q9WV32	Actin-related protein 2/3 complex subunit 1B	IDA	9618202	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00005	Angiogenesis	P00256	PLC-gamma	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00087	Fe65	PANTR|Ensembl=ENSPTRG00000003288|UniProtKB=H2Q320	Uncharacterized protein	ISS	15115822	PubMed	PTHR14058:SF5	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	CHICK|Ensembl=ENSGALG00000001334|UniProtKB=F1NLV4	Uncharacterized protein	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04393	Ras Pathway	P04557	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	BOVIN|Ensembl=ENSBTAG00000008151|UniProtKB=F1MH06	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00912	Arp2/3	ORNAN|Ensembl=ENSOANG00000004783|UniProtKB=F7FN72	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P04393	Ras Pathway	P04542	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04372	5-Hydroxytryptamine degredation	P04401	Monoamine Oxidase	CANLF|Ensembl=ENSCAFG00000014435|UniProtKB=P58027	Amine oxidase [flavin-containing] A	ISS	8602220	PubMed	PTHR43563:SF3	AMINE OXIDASE  FLAVIN-CONTAINING  A
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000011898|UniProtKB=F7HN04	Uncharacterized protein	ISS	8120095	PubMed	PTHR43912:SF8	PROTOCADHERIN-7
P00037	Ionotropic glutamate receptor pathway	P01001	KA4	MACMU|Ensembl=ENSMMUG00000022347|UniProtKB=F6ZCH5	Uncharacterized protein	ISS	1648176	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000035697|UniProtKB=Q28024	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IDA	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00877	MLCK	RAT|RGD=620934|UniProtKB=P20689	Myosin light chain kinase 2, skeletal/cardiac muscle	IDA	11157482	PubMed	PTHR45210:SF1	MYOSIN LIGHT CHAIN KINASE 2, SKELETAL/CARDIAC MUSCLE
P00048	PI3 kinase pathway	P01194	S6K	PANTR|Ensembl=ENSPTRG00000009477|UniProtKB=H2QDK7	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00011	Blood coagulation	P00458	GP IIIa	MOUSE|MGI=MGI=96612|UniProtKB=O54890	Integrin beta-3	ISS	124968	gi	PTHR10082:SF25	INTEGRIN BETA-3
P06664	Gonadotropin-releasing hormone receptor pathway	P06757	JUN	MOUSE|MGI=MGI=96647|UniProtKB=P09450	Transcription factor jun-B	RCA	10664585	PubMed	PTHR11462:SF37	TRANSCRIPTION FACTOR JUN-B
P00049	Parkinson disease	P01234	GRK	MOUSE|MGI=MGI=87940|UniProtKB=Q99MK8	Beta-adrenergic receptor kinase 1	IDA	8288567	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P00057	Wnt signaling pathway	P01434	sFRP	RAT|RGD=1310369|UniProtKB=D3ZTV6	Protein Sfrp5	ISS	9096311	PubMed	PTHR11309:SF46	SECRETED FRIZZLED-RELATED PROTEIN 5
P00011	Blood coagulation	P00418	Fibrin monomer	HUMAN|HGNC=3662|UniProtKB=P02675	Fibrinogen beta chain	ISS	6575700	PubMed	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	DANRE|ZFIN=ZDB-GENE-010705-1|UniProtKB=Q90Z40	Guanine nucleotide-binding protein subunit gamma	IDA	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00010	B cell activation	P00391	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	PANTR|Ensembl=ENSPTRG00000013428|UniProtKB=H2QK88	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF358	MYOSIN-7B
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00009	Axon guidance mediated by netrin	P00363	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00054	Toll receptor signaling pathway	P01354	NFkappaB	CHICK|Ensembl=ENSGALG00000012304|UniProtKB=Q04861	Nuclear factor NF-kappa-B p105 subunit	ISS	9133421	PubMed	PTHR24169:SF9	NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	CHICK|Ensembl=ENSGALG00000004571|UniProtKB=Q5ZL39	Serine/threonine-protein phosphatase	ISS	8392016	PubMed	PTHR11668:SF204	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-GAMMA CATALYTIC SUBUNIT
P00056	VEGF signaling pathway	P01420	FAK	CANLF|Ensembl=ENSCAFG00000001217|UniProtKB=E2RGP8	Uncharacterized protein (Fragment)	ISS	12640026	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00029	Huntington disease	P00786	ARF	HUMAN|HGNC=695|UniProtKB=P40617	ADP-ribosylation factor-like protein 4A	IPI	12932731	PubMed	PTHR11711:SF139	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 4A
P00021	FGF signaling pathway	P00644	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	IPI	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	DANRE|ZFIN=ZDB-GENE-991119-4|UniProtKB=Q9W6T7	Presenilin-1	TAS	12101103	PubMed	PTHR10202:SF18	PRESENILIN-1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=3023|UniProtKB=P14416	D(2) dopamine receptor	IDA	11861492	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00048	PI3 kinase pathway	P01182	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01143	ERK	RAT|RGD=620967|UniProtKB=F1M9D0	Protein Map3k2	ISS			PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00384	p38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IDA	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00641	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	RAT|RGD=71027|UniProtKB=P42264	Glutamate receptor ionotropic, kainate 3	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	TAS	10851062	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00048	PI3 kinase pathway	P01182	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	91232861	PubMed	PTHR24070:SF385	GTPASE HRAS
P02775	Salvage pyrimidine ribonucleotides	P03149	Cytidine kinase	BOVIN|Ensembl=ENSBTAG00000010810|UniProtKB=Q0P5A4	Uridine-cytidine kinase 1	ISS			PTHR10285:SF66	URIDINE-CYTIDINE KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06832	c-Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	RCA	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	RAT|RGD=2257|UniProtKB=P62161	Calmodulin	ISS	7514101	PubMed	PTHR23050:SF311	CALMODULIN
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00010	B cell activation	P00384	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00036	Interleukin signaling pathway	P00969	Signaling subunit	PANTR|Ensembl=ENSPTRG00000016887|UniProtKB=H2R0A7	Interleukin 6 signal transducer (Gp130, oncostatin M receptor)	ISS	10210178	PubMed	PTHR23036:SF83	INTERLEUKIN-6 RECEPTOR SUBUNIT BETA
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	RAT|RGD=70958|UniProtKB=P19492	Glutamate receptor 3	ISS	12941441	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00036	Interleukin signaling pathway	P00987	SRF	MOUSE|MGI=MGI=106658|UniProtKB=Q9JM73	Serum response factor	ISS	15647354	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00021	FGF signaling pathway	P00643	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	PANTR|Ensembl=ENSPTRG00000004216|UniProtKB=H2Q4M8	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF125	MATRIX METALLOPROTEINASE-20
P00006	Apoptosis signaling pathway	P00302	ATF	MACMU|Ensembl=ENSMMUG00000004049|UniProtKB=F6ZR51	Uncharacterized protein	ISS	11390664	PubMed	PTHR22952:SF116	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-6 ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00057	Wnt signaling pathway	P01432	Beta-Catenin	RAT|RGD=70487|UniProtKB=Q9WU82	Catenin beta-1	IDA	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00060	Ubiquitin proteasome pathway	P01491	E2	MOUSE|MGI=MGI=1920568|UniProtKB=Q6ZWY6	Ubiquitin-conjugating enzyme E2 D2B	ISS			PTHR24068:SF44	UBIQUITIN-CONJUGATING ENZYME E2 D2B
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=69237|UniProtKB=Q9QYP2	Cadherin EGF LAG seven-pass G-type receptor 2 (Fragment)	ISS	8120095	PubMed	PTHR24026:SF32	CADHERIN EGF LAG SEVEN-PASS G-TYPE RECEPTOR 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	TAS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00023	General transcription regulation	P00658	TBP-associated factors	SCHPO|PomBase=SPAC3A12.05c|UniProtKB=P87121	Transcription initiation factor TFIID subunit 2	ISS			PTHR15137:SF9	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	DROME|FlyBase=FBgn0013307|UniProtKB=P40807	Ornithine decarboxylase 1	ISS			PTHR11482:SF6	ORNITHINE DECARBOXYLASE 1-RELATED
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	RAT|RGD=619877|UniProtKB=P19804	Nucleoside diphosphate kinase B	ISS			PTHR11349:SF57	NUCLEOSIDE DIPHOSPHATE KINASE B
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MOUSE|MGI=MGI=105062|UniProtKB=Q8K592	Anti-Muellerian hormone type-2 receptor	TAS	9395284	PubMed	PTHR23255:SF49	ANTI-MUELLERIAN HORMONE TYPE-2 RECEPTOR
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8684|UniProtKB=Q9Y5F0	Protocadherin beta-13	IDA	8120095	PubMed	PTHR24028:SF61	PROTOCADHERIN BETA-13
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	CANLF|Ensembl=ENSCAFG00000012565|UniProtKB=F1PRW0	Uncharacterized protein	ISS	13645506	gi	PTHR10223:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MOUSE|MGI=MGI=1915021|UniProtKB=Q9CPW4	Actin-related protein 2/3 complex subunit 5	ISS	9230079	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P04393	Ras Pathway	P04563	Ets	MACMU|Ensembl=ENSMMUG00000020706|UniProtKB=F6PU72	Uncharacterized protein	ISS	15579511	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00049	Parkinson disease	P01236	Casein kinase II	RAT|RGD=619978|UniProtKB=P67874	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00005	Angiogenesis	P00206	Wnt	RAT|RGD=69079|UniProtKB=M0R9D3	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00023	General transcription regulation	P00668	TFIIB	THEKO|EnsemblGenome=TK1280|UniProtKB=Q5JGN1	Transcription initiation factor IIB 1	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00038	JAK/STAT signaling pathway	P01027	STAT	PANTR|Ensembl=ENSPTRG00000009199|UniProtKB=H2QD19	Signal transducer and activator of transcription	ISS	8584036	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00223	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00049	Parkinson disease	P01227	20S proteasome	ORYSJ|EnsemblGenome=OS03G0180400|UniProtKB=Q9LSU3	Proteasome subunit alpha type-6	TAS	12859888	PubMed	PTHR11599:SF11	PROTEASOME SUBUNIT ALPHA TYPE-6
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00892	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8316835	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P02752	Mannose metabolism	P03015	GDP-Mannose 4,6-dehydratase	MONDO|Ensembl=ENSMODG00000008260|UniProtKB=F6Z8R0	Uncharacterized protein	ISS	9603974	PubMed	PTHR43715:SF1	GDP-MANNOSE 4,6 DEHYDRATASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MONDO|Ensembl=ENSMODG00000019755|UniProtKB=F6WN64	Actin-related protein 2/3 complex subunit 5	ISS	12932731	PubMed	PTHR12644:SF2	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5-LIKE PROTEIN
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	TAS	10514528	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00570	PKA	LEIMA|EnsemblGenome=LmjF.18.1080|UniProtKB=Q27687	Protein kinase A catalytic subunit	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00056	VEGF signaling pathway	P01411	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	HUMAN|HGNC=10432|UniProtKB=P51812	Ribosomal protein S6 kinase alpha-3	ISS	6755374	gi	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00018	EGF receptor signaling pathway	P00561	STAT	PANTR|Ensembl=ENSPTRG00000009199|UniProtKB=H2QD19	Signal transducer and activator of transcription	ISS	96210005	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ORYSJ|EnsemblGenome=OS06G0154500|UniProtKB=Q84UI5	Mitogen-activated protein kinase 1	ISS	10589842	PubMed	PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01164	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00034	Integrin signalling pathway	P00951	Jnk	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IDA	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00021	FGF signaling pathway	P00628	JNK1-3	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00012	Cadherin signaling pathway	P00470	F-actin	DICDI|dictyBase=DDB_G0275023|UniProtKB=Q553U6	Putative actin-22	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00046	Oxidative stress response	P01134	cPLA2	MACMU|Ensembl=ENSMMUG00000021423|UniProtKB=F7EEZ1	Phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	HUMAN|HGNC=465|UniProtKB=Q16671	Anti-Muellerian hormone type-2 receptor	TAS	9395284	PubMed	PTHR23255:SF49	ANTI-MUELLERIAN HORMONE TYPE-2 RECEPTOR
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	XENTR|Xenbase=XB-GENE-491356|UniProtKB=Q28J24	Transcription initiation factor TFIID subunit 8	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P04393	Ras Pathway	P04560	AP1	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04393	Ras Pathway	P04574	PLD	MACMU|Ensembl=ENSMMUG00000023289|UniProtKB=F7FFD2	Uncharacterized protein	ISS	9307024	PubMed	PTHR18896:SF57	PHOSPHOLIPASE D1
P00012	Cadherin signaling pathway	P00477	GSK3beta	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00004	Alzheimer disease-presenilin pathway	P00114	actin	SCHMA|EnsemblGenome=Smp_202970|UniProtKB=G4VLN1	Putative uncharacterized protein Smp_202970	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00024	Glycolysis	P00680	Phosphoglyceromutase	MOUSE|MGI=MGI=1933118|UniProtKB=O70250	Phosphoglycerate mutase 2	RCA			PTHR11931:SF8	PHOSPHOGLYCERATE MUTASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000023202|UniProtKB=F7EU36	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00005	Angiogenesis	P00221	JNK1	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00054	Toll receptor signaling pathway	P01358	ERK1	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	DROME|FlyBase=FBgn0262866|UniProtKB=Q9VR61	Ribosomal protein S6 kinase II, isoform A	ISS	6755374	gi	PTHR24351:SF110	RIBOSOMAL PROTEIN S6 KINASE II, ISOFORM A
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	SCHPO|PomBase=SPAC1805.05|UniProtKB=O74135	Casein kinase I homolog 3	IDA	10617630	PubMed	PTHR11909:SF155	GILGAMESH, ISOFORM L
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00570	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00036	Interleukin signaling pathway	P00973	PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MACMU|Ensembl=ENSMMUG00000005819|UniProtKB=F6VKI4	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04580	TRH Receptor	CANLF|Ensembl=ENSCAFG00000000717|UniProtKB=E2R0P6	Uncharacterized protein	ISS	7509436	PubMed	PTHR24243:SF115	THYROTROPIN-RELEASING HORMONE RECEPTOR
P00056	VEGF signaling pathway	P01411	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	10218114	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	IDA	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	RCA	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00007	Axon guidance mediated by semaphorins	P00337	Sema3A	MACMU|Ensembl=ENSMMUG00000007555|UniProtKB=F6T171	Uncharacterized protein	ISS	8402908	PubMed	PTHR11036:SF23	SEMAPHORIN-3A
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04547	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00008	Axon guidance mediated by Slit/Robo	P00342	Slit	BOVIN|Ensembl=ENSBTAG00000005108|UniProtKB=F1MLJ7	Uncharacterized protein	ISS	10432110	PubMed	PTHR24373:SF107	SLIT HOMOLOG 2 PROTEIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00736	CalDAG-GEF	CANLF|Ensembl=ENSCAFG00000008674|UniProtKB=J9JHZ2	Uncharacterized protein	ISS	10835426	PubMed	PTHR23113:SF174	RAS GUANYL-RELEASING PROTEIN 1
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	PANTR|Ensembl=ENSPTRG00000020163|UniProtKB=H2QW11	BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like	ISS			PTHR11618:SF5	TRANSCRIPTION FACTOR IIIB 50 KDA SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	11840290	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00912	Arp2/3	MOUSE|MGI=MGI=1928896|UniProtKB=Q9R0Q6	Actin-related protein 2/3 complex subunit 1A	IPI	12473693	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	RCA	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	PANTR|Ensembl=ENSPTRG00000017389|UniProtKB=H2R334	Uncharacterized protein	ISS	12898568	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00018	EGF receptor signaling pathway	P00543	ERK1-2	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00983	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01162	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05918	p38 MAPK pathway	P06013	ELK	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	3183861	gi	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	XENTR|Xenbase=XB-GENE-494200|UniProtKB=F7CS79	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=15906|UniProtKB=A7E2Y1	Myosin-7B	IC	10938134	PubMed	PTHR13140:SF358	MYOSIN-7B
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04392	P53 pathway feedback loops 1	G04686	p73	RAT|RGD=1307083|UniProtKB=D4AA88	Protein Tp73	ISS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P05731	GABA-B receptor II signaling	P05760	AC	HUMAN|HGNC=232|UniProtKB=Q08828	Adenylate cyclase type 1	ISS	2491850	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IC	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00005	Angiogenesis	P00238	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	ANOGA|EnsemblGenome=AGAP002156|UniProtKB=Q7QK53	AGAP002156-PA	IDA	1333052	PubMed	PTHR24241:SF59	ADIPOKINETIC HORMONE RECEPTOR, ISOFORM C
P00010	B cell activation	P00384	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	TAS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00049	Parkinson disease	P01242	Casein kinase I	ARATH|TAIR=AT1G72710|UniProtKB=Q9CAI5	At1g72710	IDA	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00029	Huntington disease	P00790	beta-Tubulin	BRAFL|Gene=BRAFLDRAFT_124235|UniProtKB=C3Y3Q1	Putative uncharacterized protein	ISS			PTHR11588:SF89	TUBULIN BETA-4 CHAIN
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00796	Kainate receptor	TAKRU|Ensembl=ENSTRUG00000009259|UniProtKB=H2TF39	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	RAT|RGD=3697|UniProtKB=P31596	Excitatory amino acid transporter 2	ISS	94365697	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P00012	Cadherin signaling pathway	P00462	Casein kinase II	DROME|FlyBase=FBgn0000259|UniProtKB=P08182	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00010	B cell activation	P00383	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=619741|UniProtKB=F1LR98	Protein Cdh10	ISS	8120095	PubMed	PTHR24027:SF290	CADHERIN-10
P00045	Notch signaling pathway	P01108	Nicastrin	MACMU|Ensembl=ENSMMUG00000021856|UniProtKB=F7EHX8	Nicastrin	ISS	16096062	PubMed	PTHR21092:SF0	NICASTRIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00029	Huntington disease	P00774	Dynein complex	HUMAN|HGNC=2964|UniProtKB=Q13409	Cytoplasmic dynein 1 intermediate chain 2	IPI	9454836	PubMed	PTHR12442:SF22	CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN 2
P00048	PI3 kinase pathway	P01179	PKB	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS			PTHR24356:SF310	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00256	PLC-gamma	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00036	Interleukin signaling pathway	P00985	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	12855688	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	HUMAN|HGNC=4404|UniProtKB=P59768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	TAS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	BOVIN|Gene=STAT3|UniProtKB=P61635	Signal transducer and activator of transcription 3	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000008059|UniProtKB=P41984	Muscarinic acetylcholine receptor M3	IDA			PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	HUMAN|HGNC=7175|UniProtKB=P22894	Neutrophil collagenase	TAS	12834808	PubMed	PTHR10201:SF137	NEUTROPHIL COLLAGENASE
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	BOVIN|Gene=STAT3|UniProtKB=P61635	Signal transducer and activator of transcription 3	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00018	EGF receptor signaling pathway	P00551	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00839	SHIP	CANLF|Ensembl=ENSCAFG00000005743|UniProtKB=F1PNY0	Uncharacterized protein	ISS	10381377	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CHICK|Gene=ACTA2|UniProtKB=P08023	Actin, aortic smooth muscle	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04398	p53 pathway feedback loops 2	P04665	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00046	Oxidative stress response	P01129	JNK1/2	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00807	Actin	STRPU|Gene=CYIIIA|UniProtKB=P53474	Actin, cytoskeletal 3A	IDA	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	BOVIN|Gene=SLC18A2|UniProtKB=Q27963	Synaptic vesicular amine transporter	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	DROME|FlyBase=FBgn0004619|UniProtKB=Q03445	Glutamate receptor 1	IC	8804111	PubMed	PTHR18966:SF270	GLUTAMATE RECEPTOR 1-RELATED
P00019	Endothelin signaling pathway	P00591	PLCbeta	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	MONDO|Ensembl=ENSMODG00000010516|UniProtKB=F7DR73	Protein-serine/threonine kinase	ISS	10852916	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	SULSO|EnsemblGenome=SSO0382|UniProtKB=Q980D3	Glutamine-fructose-6-phosphate transaminase (Isomerizing) (GlmS-1)	ISS			PTHR10937:SF0	GH12731P-RELATED
P00057	Wnt signaling pathway	P01435	SWI/SNF	MOUSE|MGI=MGI=1915308|UniProtKB=Q9CXF7	Chromodomain-helicase-DNA-binding protein 1-like	IDA	11532957	PubMed	PTHR10799:SF949	CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1-LIKE
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	G06681	mPer1	MOUSE|MGI=MGI=1098283|UniProtKB=O35973	Period circadian protein homolog 1	RCA	20570170	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P00037	Ionotropic glutamate receptor pathway	P01018	Glu1	DROME|FlyBase=FBgn0004619|UniProtKB=Q03445	Glutamate receptor 1	ISS	12941441	PubMed	PTHR18966:SF270	GLUTAMATE RECEPTOR 1-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	HUMAN|HGNC=711|UniProtKB=P49407	Beta-arrestin-1	IDA	9388255	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P05913	Enkephalin release	P05972	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	TRIAD|EnsemblGenome=TriadG37105|UniProtKB=B3RJX8	Calmodulin	ISS	7514101	PubMed	PTHR23050:SF245	AT16150P-RELATED
P02738	De novo purine biosynthesis	P02891	GDP kinase	RAT|RGD=1583004|UniProtKB=D3ZH90	Protein Nme5	ISS			PTHR11349:SF64	NUCLEOSIDE DIPHOSPHATE KINASE HOMOLOG 5
P00059	p53 pathway	P01485	p53	ORNAN|Ensembl=ENSOANG00000013795|UniProtKB=F7DUR2	Uncharacterized protein (Fragment)	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=620023|UniProtKB=P10980	Muscarinic acetylcholine receptor M2	IDA	91373358	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01294	NFAT	CANLF|Ensembl=ENSCAFG00000011625|UniProtKB=F1PDD9	Uncharacterized protein	ISS	12787506	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00059	p53 pathway	G04702	p53	PANTR|Ensembl=ENSPTRG00000008703|UniProtKB=H2QC53	Cellular tumor antigen p53	ISS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=13404|UniProtKB=Q9P2E7	Protocadherin-10	IDA	8120095	PubMed	PTHR24028:SF0	PROTOCADHERIN-10
P00046	Oxidative stress response	P01131	MKP5	MACMU|Ensembl=ENSMMUG00000005300|UniProtKB=F7GK32	Dual specificity protein phosphatase	ISS			PTHR10159:SF305	DUAL SPECIFICITY PROTEIN PHOSPHATASE 7
P00029	Huntington disease	P00796	Kainate receptor	RAT|RGD=2732|UniProtKB=P22756	Glutamate receptor ionotropic, kainate 1	IDA	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=3234|UniProtKB=P33535	Mu-type opioid receptor	IDA	11259498	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00056	VEGF signaling pathway	P01407	Erk	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	MACMU|Ensembl=ENSMMUG00000011829|UniProtKB=F7H767	Uncharacterized protein	ISS			PTHR42884:SF8	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT3G45640|UniProtKB=Q39023	Mitogen-activated protein kinase 3	ISS	12787066	PubMed	PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02742	Tetrahydrofolate biosynthesis	P02951	GTP cyclohydrolase	NEUCR|EnsemblGenome=EFNCRG00000007940|UniProtKB=P51599	GTP cyclohydrolase 1	ISS			PTHR11109:SF0	GTP CYCLOHYDROLASE 1
P00056	VEGF signaling pathway	P01417	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00060	Ubiquitin proteasome pathway	P01491	E2	BOVIN|Ensembl=ENSBTAG00000009211|UniProtKB=Q1RML1	Ubiquitin-conjugating enzyme E2 S	ISS			PTHR44066:SF1	UBIQUITIN-CONJUGATING ENZYME E2 S
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	PANTR|Ensembl=ENSPTRG00000019407|UniProtKB=H2QUY0	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IDA	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00012	Cadherin signaling pathway	P00471	Cadherin	DROME|FlyBase=FBgn0038247|UniProtKB=Q9VFH5	Cadherin 88C	ISS	8120095	PubMed	PTHR43956:SF8	CADHERIN 88C-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=11438|UniProtKB=Q13277	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P04393	Ras Pathway	P04564	MAPKAP	DANRE|ZFIN=ZDB-GENE-030131-5532|UniProtKB=Q7T2F2	Mitogen-activated protein kinase-activated protein kinase 2a	ISS			PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	BOVIN|Ensembl=ENSBTAG00000008026|UniProtKB=P01175	Oxytocin-neurophysin 1	ISS	3768139	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	CANLF|Ensembl=ENSCAFG00000024151|UniProtKB=E2R795	Tyrosine-protein kinase receptor	ISS	11182407	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P04393	Ras Pathway	P04564	MAPKAP	BOVIN|Ensembl=ENSBTAG00000038107|UniProtKB=F1MCX5	Uncharacterized protein	ISS	7923354	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00045	Notch signaling pathway	P01104	Serrate	ORNAN|Ensembl=ENSOANG00000008425|UniProtKB=F6VUQ4	Delta-like protein	ISS	12826675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	ANOGA|EnsemblGenome=AGAP005911|UniProtKB=Q7Q6D4	AGAP005911-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=30035|UniProtKB=Q8WYR1	Phosphoinositide 3-kinase regulatory subunit 5	ISS	129387	gi	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MONDO|Ensembl=ENSMODG00000001384|UniProtKB=F7GL73	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	PANTR|Ensembl=ENSPTRG00000023062|UniProtKB=H2R2U1	Catenin (Cadherin-associated protein), beta 1, 88kDa	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	MACMU|Ensembl=ENSMMUG00000031224|UniProtKB=F7CKT2	Uncharacterized protein	ISS	10617630	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P04396	Vitamin D metabolism and pathway	P04604	FdxR	YEAST|SGD=S000002784|UniProtKB=P48360	Probable NADPH:adrenodoxin oxidoreductase, mitochondrial	ISS			PTHR11938:SF91	NADPH:ADRENODOXIN OXIDOREDUCTASE, MITOCHONDRIAL
P05731	GABA-B receptor II signaling	P05760	AC	CANLF|Ensembl=ENSCAFG00000001097|UniProtKB=E2RCX6	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00030	Hypoxia response via HIF activation	P00814	P300	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	BOVIN|Ensembl=ENSBTAG00000007599|UniProtKB=Q95KV0	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P02761	Pantothenate biosynthesis	P03069	2-Dehydropantoate reductase	BACSU|EnsemblGenome=BSU14440|UniProtKB=O31717	Uncharacterized oxidoreductase YkpB	ISS			PTHR21708:SF26	SUBFAMILY NOT NAMED
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	DICPU|Gene=DICPUDRAFT_91367|UniProtKB=F0ZB76	Putative uncharacterized protein rasD	ISS	6091907	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P04397	p53 pathway by glucose deprivation	P04641	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00007	Axon guidance mediated by semaphorins	P00331	PAK	CANLF|Ensembl=ENSCAFG00000004956|UniProtKB=E2REH3	Uncharacterized protein	ISS	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P05913	Enkephalin release	P05974	G-Protein (i)	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00054	Toll receptor signaling pathway	P01348	A20	PANTR|Ensembl=ENSPTRG00000018644|UniProtKB=H2QTT5	Tumor necrosis factor, alpha-induced protein 3	ISS			PTHR13367:SF3	TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 3
P00048	PI3 kinase pathway	P01192	p110	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01465	Ggamma	BOVIN|Ensembl=ENSBTAG00000003043|UniProtKB=P63212	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01084	CHT1	ANOGA|EnsemblGenome=AGAP002366|UniProtKB=Q7QBY8	AGAP002366-PA	RCA			PTHR11819:SF12	HIGH-AFFINITY CHOLINE TRANSPORTER 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	RAT|RGD=2734|UniProtKB=Q01812	Glutamate receptor ionotropic, kainate 4	ISS	11319238	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00021	FGF signaling pathway	P00632	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05915	Opioid proenkephalin pathway	P05993	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04396	Vitamin D metabolism and pathway	P04608	24-Hydroxylase	CHICK|Ensembl=ENSGALG00000012070|UniProtKB=F1NUL6	Uncharacterized protein	IDA	11686044	PubMed	PTHR24291:SF5	1,25-DIHYDROXYVITAMIN D 3  24-HYDROXYLASE, MITOCHONDRIAL
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	PANTR|Ensembl=ENSPTRG00000017581|UniProtKB=H2QS37	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF179	REGULATOR OF G-PROTEIN SIGNALING 14
P00012	Cadherin signaling pathway	P00464	Fyn	MACMU|Ensembl=ENSMMUG00000017017|UniProtKB=F7FVL2	Tyrosine-protein kinase	ISS	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00021	FGF signaling pathway	P00632	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=97614|UniProtKB=Q8R3B1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	10934033	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00012	Cadherin signaling pathway	P00474	Wnt	CHICK|Gene=WNT2B|UniProtKB=Q98SN7	Protein Wnt-2b	IDA	11266476	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	IC	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00010	B cell activation	P00384	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00056	VEGF signaling pathway	P01425	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	10395542	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P05730	Endogenous cannabinoid signaling	P05751	Galpha	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	RAT|RGD=1311192|UniProtKB=A0A0G2K3R1	Protein Map3k4	ISS	602425	OMIM	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01322	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06010	proopiomelanocortin	PANTR|Ensembl=ENSPTRG00000011721|UniProtKB=H2R8Y3	Uncharacterized protein	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P04379	Beta3 adrenergic receptor signaling pathway	P04449	Beta3	HUMAN|HGNC=288|UniProtKB=P13945	Beta-3 adrenergic receptor	ISS	11943840	PubMed	PTHR24248:SF3	BETA-3 ADRENERGIC RECEPTOR
P00048	PI3 kinase pathway	P01198	FOXO	MACMU|Ensembl=ENSMMUG00000020369|UniProtKB=F6UMX8	Uncharacterized protein	ISS	12048180	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	ARATH|TAIR=AT4G34340|UniProtKB=Q9SYZ9	Transcription initiation factor TFIID subunit 8	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00004	Alzheimer disease-presenilin pathway	P00114	actin	RAT|RGD=2026|UniProtKB=P68035	Actin, alpha cardiac muscle 1	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04397	p53 pathway by glucose deprivation	P04640	p53	MOUSE|MGI=MGI=1330810|UniProtKB=O88898	Tumor protein 63	TAS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	DANRE|ZFIN=ZDB-GENE-070524-2|UniProtKB=B6E506	Dopamine receptor D1	ISS			PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00005	Angiogenesis	P00230	PDGFR	CANLF|Ensembl=ENSCAFG00000002057|UniProtKB=F1PUX6	Platelet-derived growth factor receptor alpha	ISS	12374780	PubMed	PTHR24416:SF52	PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MONDO|Ensembl=ENSMODG00000009618|UniProtKB=F6REU0	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00005	Angiogenesis	P00244	MAPKAPK2/3	MOUSE|MGI=MGI=109298|UniProtKB=P49138	MAP kinase-activated protein kinase 2	ISS	14672329	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00047	PDGF signaling pathway	P01167	Ets	RAT|RGD=1305859|UniProtKB=D4A3N9	E74-like factor 5 (Predicted)	ISS	15298723	PubMed	PTHR11849:SF15	ETS-RELATED TRANSCRIPTION FACTOR ELF-5
P00029	Huntington disease	P00780	Microtubule	CAEEL|WormBase=WBGene00003171|UniProtKB=P12456	Tubulin beta-1 chain	IDA	12932731	PubMed	PTHR11588:SF255	TUBA7L PROTEIN
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00807	Actin	ARATH|TAIR=AT3G18780|UniProtKB=Q96292	Actin-2	IDA	10974003	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00057	Wnt signaling pathway	P01443	Phospholipase C	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P02771	Pyrimidine Metabolism	P03128	Dihydrouracil Dehydrogenase	HUMAN|HGNC=3012|UniProtKB=Q12882	Dihydropyrimidine dehydrogenase [NADP(+)]	TAS	8912928	PubMed	PTHR43073:SF2	DIHYDROPYRIMIDINE DEHYDROGENASE  NADP +
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000011757|UniProtKB=Q9XT97	Presenilin-1	TAS	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	IC	8170357	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IGI	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04398	p53 pathway feedback loops 2	P04662	cyclin G	BOVIN|Ensembl=ENSBTAG00000006607|UniProtKB=Q5E9I1	Cyclin-G1	ISS	15077171	PubMed	PTHR10177:SF59	CYCLIN-G1
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000013316|UniProtKB=H2QK23	Uncharacterized protein	ISS	12181435	PubMed	PTHR24229:SF52	SOMATOSTATIN RECEPTOR TYPE 4
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	BOVIN|Ensembl=ENSBTAG00000010386|UniProtKB=Q3MHR7	Actin-related protein 2/3 complex subunit 2	ISS	12473693	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00021	FGF signaling pathway	P00648	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	89186920	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00029	Huntington disease	P00778	NMDA receptor	HUMAN|HGNC=16767|UniProtKB=Q8TCU5	Glutamate receptor ionotropic, NMDA 3A	IDA	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MOUSE|MGI=MGI=107443|UniProtKB=P33766	fMet-Leu-Phe receptor	IDA	12470609	PubMed	PTHR24225:SF15	FMET-LEU-PHE RECEPTOR
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	1333286	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00034	Integrin signalling pathway	P00925	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IDA	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DICPU|Gene=DICPUDRAFT_93216|UniProtKB=F1A421	Guanine nucleotide-binding protein subunit beta	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00034	Integrin signalling pathway	P00948	Rho	RAT|RGD=1306172|UniProtKB=Q5HZE6	Protein Rnd2	ISS	11973360	PubMed	PTHR24072:SF21	RHO-RELATED GTP-BINDING PROTEIN RHON
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	DANRE|ZFIN=ZDB-GENE-040520-2|UniProtKB=Q5U385	TATA box-binding protein-like protein 1	ISS	600075	OMIM	PTHR10126:SF13	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00056	VEGF signaling pathway	P01413	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	IC	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00021	FGF signaling pathway	P00626	Spry	MACMU|Ensembl=ENSMMUG00000014175|UniProtKB=F7ALK4	Uncharacterized protein	ISS	10330503	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MACMU|Ensembl=ENSMMUG00000000605|UniProtKB=F6Y8V8	Uncharacterized protein	ISS	9554852	PubMed	PTHR10845:SF11	AXIN-1
P00021	FGF signaling pathway	P00624	14-3-3	BOVIN|Gene=YWHAG|UniProtKB=P68252	14-3-3 protein gamma	ISS	99360936	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00029	Huntington disease	P00796	Kainate receptor	CHICK|Ensembl=ENSGALG00000002098|UniProtKB=F1P0L4	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CAEEL|WormBase=WBGene00001187|UniProtKB=Q8MQA1	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00006	Apoptosis signaling pathway	P00259	TNF	HUMAN|HGNC=6709|UniProtKB=P01374	Lymphotoxin-alpha	ISS			PTHR11471:SF31	LYMPHOTOXIN-ALPHA
P00053	T cell activation	P01331	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00047	PDGF signaling pathway	P01158	PDGF receptor A	RAT|RGD=3284|UniProtKB=P20786	Platelet-derived growth factor receptor alpha	RCA			PTHR24416:SF52	PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	MACMU|Ensembl=ENSMMUG00000012422|UniProtKB=F7DJH4	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02738	De novo purine biosynthesis	P02902	ADP reductase	RAT|RGD=2323655|UniProtKB=D4A7M6	Protein LOC100359539	ISS			PTHR23409:SF20	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00005	Angiogenesis	P00206	Wnt	BOVIN|Ensembl=ENSBTAG00000015364|UniProtKB=E1BEN9	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00034	Integrin signalling pathway	P00917	ELMO	MOUSE|MGI=MGI=2153044|UniProtKB=Q8BPU7	Engulfment and cell motility protein 1	IDA	12879077	PubMed	PTHR12771:SF23	ENGULFMENT AND CELL MOTILITY PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	MOUSE|MGI=MGI=2384786|UniProtKB=Q91XE9	Cyclic AMP-responsive element-binding protein 3-like protein 3	ISS	608986	OMIM	PTHR22952:SF98	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 3
P04398	p53 pathway feedback loops 2	P04665	AKT	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	ISS	22084520	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00015	Circadian clock system	G01501	cry	MACMU|Ensembl=ENSMMUG00000002453|UniProtKB=F7HH05	Cryptochrome-2	ISS	14507900	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05918	p38 MAPK pathway	P06021	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00034	Integrin signalling pathway	P00932	FAK	BOVIN|Ensembl=ENSBTAG00000009578|UniProtKB=G3N3B7	Uncharacterized protein	ISS	9182576	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P00057	Wnt signaling pathway	P01444	Wnt	CHICK|Ensembl=ENSGALG00000014235|UniProtKB=Q3L254	Protein Wnt-7b	ISS	8717036	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P02730	Asparagine and aspartate biosynthesis	P02853	Asparagine synthetase	ORYSJ|EnsemblGenome=OS06G0265000|UniProtKB=Q43011	Asparagine synthetase [glutamine-hydrolyzing] 2	ISS			PTHR11772:SF13	ASPARAGINE SYNTHETASE  GLUTAMINE-HYDROLYZING  2-RELATED
P00006	Apoptosis signaling pathway	P00312	MKK7	MOUSE|MGI=MGI=1346871|UniProtKB=Q8CE90	Dual specificity mitogen-activated protein kinase kinase 7	IDA			PTHR24361:SF387	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	TAKRU|Ensembl=ENSTRUG00000014739|UniProtKB=H2UL58	Tyrosine-protein kinase	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00018	EGF receptor signaling pathway	P00549	EGF	HUMAN|HGNC=1121|UniProtKB=P35070	Probetacellulin	ISS			PTHR10740:SF3	PROBETACELLULIN
P00025	Hedgehog signaling pathway	P00692	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05918	p38 MAPK pathway	P06040	MSK1	MACMU|Ensembl=ENSMMUG00000005586|UniProtKB=F7G4I3	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF115	RIBOSOMAL PROTEIN S6 KINASE ALPHA-5
P00009	Axon guidance mediated by netrin	P00366	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000012539|UniProtKB=H2RC03	Uncharacterized protein	ISS			PTHR11824:SF7	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4
P00021	FGF signaling pathway	P00633	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00036	Interleukin signaling pathway	P00970	Interleukin	BOVIN|Ensembl=ENSBTAG00000019716|UniProtKB=P79255	Interleukin-8	IC	124361	gi	PTHR10179:SF70	INTERLEUKIN-8
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	BOVIN|Ensembl=ENSBTAG00000001626|UniProtKB=A0JNE9	CTP synthase	ISS			PTHR11550:SF8	CTP SYNTHASE 1
P05917	Opioid proopiomelanocortin pathway	P06007	alpha-MSH	DANRE|ZFIN=ZDB-GENE-041014-294|UniProtKB=Q5SPP4	Uncharacterized protein	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00006	Apoptosis signaling pathway	P00274	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	CANLF|Ensembl=ENSCAFG00000000178|UniProtKB=J9P315	Uncharacterized protein	ISS	11907044	PubMed	PTHR44025:SF2	PROLOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1
P00034	Integrin signalling pathway	P00941	Integrin alpha	DROME|FlyBase=FBgn0003328|UniProtKB=O44386	Integrin alpha-PS3	IPI	3487386	PubMed	PTHR23220:SF83	INTEGRIN ALPHA-PS3-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IDA	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	MONDO|Ensembl=ENSMODG00000020352|UniProtKB=F7FKB2	Uncharacterized protein	ISS	94365697	PubMed	PTHR11958:SF24	EXCITATORY AMINO ACID TRANSPORTER 1
P00018	EGF receptor signaling pathway	P00542	EGFR	PANTR|Ensembl=ENSPTRG00000019196|UniProtKB=H2QUL1	Receptor protein-tyrosine kinase	ISS	20540545	gi	PTHR24416:SF91	EPIDERMAL GROWTH FACTOR RECEPTOR
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00036	Interleukin signaling pathway	P00970	Interleukin	PANTR|Ensembl=ENSPTRG00000011502|UniProtKB=H2QH62	Interleukin 11	ISS	2145578	PubMed	PTHR16922:SF0	INTERLEUKIN-11
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00561	STAT	CANLF|Ensembl=ENSCAFG00000015346|UniProtKB=E2RE22	Signal transducer and activator of transcription	ISS	95236292	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	RAT|RGD=1309994|UniProtKB=F1M111	Protein Myo5c	ISS			PTHR13140:SF313	UNCONVENTIONAL MYOSIN-VC
P04384	Gamma-aminobutyric acid synthesis	P04480	GABA aminotransferase	XENTR|Xenbase=XB-GENE-957494|UniProtKB=B2GUT2	LOC100158654 protein	ISS	8133261	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	HUMAN|HGNC=2091|UniProtKB=P09497	Clathrin light chain B	ISS	9388255	PubMed	PTHR10639:SF2	CLATHRIN LIGHT CHAIN B
P00051	TCA cycle	P01268	Aconitase	MACMU|Ensembl=ENSMMUG00000001454|UniProtKB=F7BKH7	Aconitate hydratase, mitochondrial	RCA			PTHR43160:SF3	ACONITATE HYDRATASE, MITOCHONDRIAL
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	CHICK|Ensembl=ENSGALG00000001383|UniProtKB=F1NJL4	Uncharacterized protein	ISS	15118808	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P00018	EGF receptor signaling pathway	P00551	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	DROME|FlyBase=FBgn0037325|UniProtKB=Q7JWT4	AT15039p	IDA	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00560	Raf-1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MACMU|Ensembl=ENSMMUG00000007333|UniProtKB=F7EE07	Growth/differentiation factor 5	ISS	9759503	PubMed	PTHR11848:SF44	GROWTH/DIFFERENTIATION FACTOR 5
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00047	PDGF signaling pathway	P01159	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05915	Opioid proenkephalin pathway	P05989	leu-Enkephalin	RAT|RGD=68946|UniProtKB=P04094	Proenkephalin-A	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05966	EPB41	RAT|RGD=71087|UniProtKB=Q9WTP0	Band 4.1-like protein 1	ISS	12181426	PubMed	PTHR23280:SF24	BAND 4.1-LIKE PROTEIN 1
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00056	VEGF signaling pathway	P01425	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00054	Toll receptor signaling pathway	P01358	ERK1	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	ANOGA|EnsemblGenome=AGAP001506|UniProtKB=Q7PXP3	AGAP001506-PA	IC			PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	DICDI|dictyBase=DDB_G0273069|UniProtKB=P22887	Nucleoside diphosphate kinase, cytosolic	ISS			PTHR11349:SF64	NUCLEOSIDE DIPHOSPHATE KINASE HOMOLOG 5
P00021	FGF signaling pathway	P00644	p38	DROME|FlyBase=FBgn0024846|UniProtKB=O61443	Mitogen-activated protein kinase 14B	ISS	10514528	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MACMU|Ensembl=ENSMMUG00000022111|UniProtKB=F7H7W3	Ribosomal protein S6 kinase	ISS	12769834	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	CANLF|Ensembl=ENSCAFG00000018170|UniProtKB=E2RPM8	Tyrosine-protein kinase receptor	ISS	11182407	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MOUSE|MGI=MGI=95821|UniProtKB=Q01097	Glutamate receptor ionotropic, NMDA 2B	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P02772	Pyruvate metabolism	P03133	Pyruvate Dehydrogenase	SCHPO|PomBase=SPAC26F1.03|UniProtKB=Q10489	Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial	ISS	11859360	PubMed	PTHR11516:SF40	PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00567	PKG	PANTR|Ensembl=ENSPTRG00000002509|UniProtKB=H2Q1X0	cGMP-dependent protein kinase	ISS	9099696	PubMed	PTHR24353:SF68	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01428	Frizzled	HUMAN|HGNC=4038|UniProtKB=Q9UP38	Frizzled-1	IDA	11212302	PubMed	PTHR11309:SF81	FRIZZLED-1
P00057	Wnt signaling pathway	P01435	SWI/SNF	DROME|FlyBase=FBgn0025463|UniProtKB=Q9VYG2	Brahma-associated protein of 60 kDa	IDA	11532957	PubMed	PTHR13844:SF7	BRAHMA-ASSOCIATED PROTEIN OF 60 KDA
P05730	Endogenous cannabinoid signaling	P05746	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P02738	De novo purine biosynthesis	P02892	5-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase	DROME|FlyBase=FBgn0038467|UniProtKB=Q9VEP6	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P00012	Cadherin signaling pathway	P00468	Src	MONDO|Ensembl=ENSMODG00000000247|UniProtKB=F6WR53	Tyrosine-protein kinase	ISS	8054685	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	9199552	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	HUMAN|HGNC=8528|UniProtKB=P01178	Oxytocin-neurophysin 1	ISS	6717565	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00034	Integrin signalling pathway	P00923	Arf1	CHICK|Ensembl=ENSGALG00000005393|UniProtKB=F1NN08	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF234	ADP-RIBOSYLATION FACTOR 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00029	Huntington disease	P00775	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	20010089	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00005	Angiogenesis	P00226	Delta/Serrate	HUMAN|HGNC=2907|UniProtKB=P80370	Protein delta homolog 1	ISS			PTHR24052:SF11	PROTEIN DELTA HOMOLOG 1
P06210	Activin beta signaling pathway	P06233	MED	DROME|FlyBase=FBgn0011655|UniProtKB=O62609	Mothers against decapentaplegic homolog	IEA	9395284	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P00046	Oxidative stress response	P01135	p38	DROME|FlyBase=FBgn0015765|UniProtKB=O62618	Mitogen-activated protein kinase 14A	TAS	11274345	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00011	Blood coagulation	P00458	GP IIIa	MOUSE|MGI=MGI=96612|UniProtKB=O54890	Integrin beta-3	ISS	7949057	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00036	Interleukin signaling pathway	P00973	PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00887	IRS 1-4	XENTR|Xenbase=XB-GENE-479893|UniProtKB=F6YCQ0	Uncharacterized protein	ISS	5031805	gi	PTHR10614:SF2	INSULIN RECEPTOR SUBSTRATE 4
P04393	Ras Pathway	P04579	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	95096035	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P05912	Dopamine receptor mediated signaling pathway	P05960	VAT2	RAT|RGD=3694|UniProtKB=Q01827	Synaptic vesicular amine transporter	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g242065|UniProtKB=A7S0V7	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00005	Angiogenesis	P00182	p38MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P06215	MYO signaling pathway	P06310	BABO	DROME|FlyBase=FBgn0011300|UniProtKB=A1Z7L8	Receptor protein serine/threonine kinase	IEA	http://www.reactome.org/	Website	PTHR23255:SF71	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00021	FGF signaling pathway	P00648	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	XENTR|Xenbase=XB-GENE-977853|UniProtKB=F7EBE7	Uncharacterized protein	ISS	10051575	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MOUSE|MGI=MGI=1339709|UniProtKB=P13541	Myosin-3	ISS	89264452	PubMed	PTHR13140:SF427	MYOSIN-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Gene=HTR1D|UniProtKB=P11614	5-hydroxytryptamine receptor 1D	IDA	12441358	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00053	T cell activation	P01320	PLC-gamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IDA	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05915	Opioid proenkephalin pathway	P05995	proenkephalin	PANTR|Ensembl=ENSPTRG00000020270|UniProtKB=H2QW70	Proenkephalin	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CHICK|Ensembl=ENSGALG00000014620|UniProtKB=F1N8P3	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00012	Cadherin signaling pathway	P00470	F-actin	ORYSJ|EnsemblGenome=OS03G0718100|UniProtKB=Q10DV7	Actin-1	IC	10974003	PubMed	PTHR11937:SF364	ACTIN-11
P00049	Parkinson disease	P01211	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04397	p53 pathway by glucose deprivation	P04640	p53	RAT|RGD=1307083|UniProtKB=D4AA88	Protein Tp73	ISS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00036	Interleukin signaling pathway	P00968	Ikk	MACMU|Ensembl=ENSMMUG00000008351|UniProtKB=F7HRV5	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P05915	Opioid proenkephalin pathway	P05994	G-protein	CAEEL|WormBase=WBGene00001680|UniProtKB=Q20636	Guanine nucleotide-binding protein subunit beta-2	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00036	Interleukin signaling pathway	P00990	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	TAS	3755548	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00017	DNA replication	P00534	PCNA	XENTR|Xenbase=XB-GENE-972522|UniProtKB=Q66KJ8	Proliferating cell nuclear antigen	ISS	90361083	PubMed	PTHR11352:SF0	PROLIFERATING CELL NUCLEAR ANTIGEN
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	MACMU|Ensembl=ENSMMUG00000011773|UniProtKB=F7HQF4	Uncharacterized protein	ISS	8143856	PubMed	PTHR24247:SF31	5-HYDROXYTRYPTAMINE RECEPTOR 2B
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P06959	CCKR signaling map	P07118	CCK-83	HUMAN|HGNC=1569|UniProtKB=P06307	Cholecystokinin	RCA		PubMed	PTHR10786:SF0	CHOLECYSTOKININ
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00012	Cadherin signaling pathway	P00474	Wnt	CHICK|Ensembl=ENSGALG00000004790|UniProtKB=P49337	Protein Wnt-4	IDA	8717036	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P02775	Salvage pyrimidine ribonucleotides	P03149	Cytidine kinase	CHICK|Ensembl=ENSGALG00000006040|UniProtKB=F1NB19	Uridine-cytidine kinase	ISS			PTHR10285:SF68	URIDINE-CYTIDINE KINASE-LIKE 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT1G59580|UniProtKB=Q39022	Mitogen-activated protein kinase 2	ISS	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	AQUAE|EnsemblGenome=aq_166|UniProtKB=O66553	Pyrroline-5-carboxylate reductase	ISS			PTHR11645:SF0	PYRROLINE-5-CARBOXYLATE REDUCTASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DROME|FlyBase=FBgn0000046|UniProtKB=P10981	Actin-87E	IC	11889126	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00007	Axon guidance mediated by semaphorins	P00330	CRAM	MACMU|Ensembl=ENSMMUG00000019731|UniProtKB=F7B606	Uncharacterized protein	ISS	10851247	PubMed	PTHR11647:SF58	DIHYDROPYRIMIDINASE-RELATED PROTEIN 5
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	MACMU|Ensembl=ENSMMUG00000014817|UniProtKB=F6VXD8	Uncharacterized protein	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	ORNAN|Ensembl=ENSOANG00000015652|UniProtKB=F7FY70	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00034	Integrin signalling pathway	P00928	alpha actinin	CHICK|Gene=ACTN1|UniProtKB=P05094	Alpha-actinin-1	IPI	2116421	PubMed	PTHR43947:SF3	ALPHA-ACTININ-1
P00019	Endothelin signaling pathway	P00584	Gs	MACMU|Ensembl=ENSMMUG00000010266|UniProtKB=F6PV18	Uncharacterized protein	ISS	6309844	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	HUMAN|HGNC=7851|UniProtKB=Q13232	Nucleoside diphosphate kinase 3	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00702	CPB	HUMAN|HGNC=18854|UniProtKB=Q8TEY5	Cyclic AMP-responsive element-binding protein 3-like protein 4	ISS			PTHR22952:SF105	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 4
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00034	Integrin signalling pathway	P00932	FAK	RAT|RGD=628758|UniProtKB=P70600	Protein-tyrosine kinase 2-beta	IPI	10753828	PubMed	PTHR24418:SF94	PROTEIN-TYROSINE KINASE 2-BETA
P00057	Wnt signaling pathway	P01444	Wnt	MACMU|Ensembl=ENSMMUG00000000180|UniProtKB=F7HJM7	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00048	PI3 kinase pathway	P01188	Gbetagamma	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00059	p53 pathway	P04630	PP2A	MACMU|Ensembl=ENSMMUG00000020819|UniProtKB=F7HSM1	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00778	NMDA receptor	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	IDA	11319238	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	MOUSE|MGI=MGI=104755|UniProtKB=P48545	G protein-activated inward rectifier potassium channel 4	IDA	12374786	PubMed	PTHR11767:SF52	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	20384797	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P02771	Pyrimidine Metabolism	P03126	Nucleoside Phosphorylase	ECOLI|EcoGene=EG10219|UniProtKB=P07650	Thymidine phosphorylase	ISS	11677608	PubMed	PTHR10515:SF0	THYMIDINE PHOSPHORYLASE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00029	Huntington disease	P00786	ARF	XENTR|Xenbase=XB-GENE-968852|UniProtKB=Q6P7Z6	Uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF294	ADP-RIBOSYLATION FACTOR 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06834	MAP3Ks	MOUSE|MGI=MGI=1346874|UniProtKB=Q61084	Mitogen-activated protein kinase kinase kinase 3	RCA	9006902	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P04393	Ras Pathway	P04572	JNK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	ISS	11707292	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00048	PI3 kinase pathway	P01198	FOXO	RAT|RGD=1309196|UniProtKB=D3ZBQ1	Forkhead box O3a (Predicted)	ISS	14775847	gi	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00369	MEKK	RAT|RGD=1304575|UniProtKB=B5DF98	Map3k3 protein	ISS	8649450	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00839	SHIP	HUMAN|HGNC=6080|UniProtKB=O15357	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	ISS	10610720	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	IDA	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P02788	Xanthine and guanine salvage pathway	P03250	Guanosine phosphorylase	PANTR|Ensembl=ENSPTRG00000006095|UniProtKB=H2Q7W4	Purine nucleoside phosphorylase	ISS			PTHR11904:SF12	PURINE NUCLEOSIDE PHOSPHORYLASE
P00049	Parkinson disease	P01227	20S proteasome	MACMU|Ensembl=ENSMMUG00000011896|UniProtKB=F7HN06	Proteasome subunit beta type	ISS	12859888	PubMed	PTHR11599:SF41	PROTEASOME SUBUNIT BETA TYPE-10
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00012	Cadherin signaling pathway	P00463	betacatenin	CHICK|Ensembl=ENSGALG00000011905|UniProtKB=F1NHT7	Uncharacterized protein	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00025	Hedgehog signaling pathway	P00682	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05938	RhoA	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	RCA	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00007	Axon guidance mediated by semaphorins	P00341	Rho	XENTR|Xenbase=XB-GENE-941426|UniProtKB=Q28HZ4	Novel Rho protein	ISS			PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00006	Apoptosis signaling pathway	P00310	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	IDA	12660731	PubMed	PTHR10048:SF14	PI-3 KINASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	CANLF|Ensembl=ENSCAFG00000004930|UniProtKB=E2RFB5	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	XENTR|Xenbase=XB-GENE-485517|UniProtKB=F6WCX0	Uncharacterized protein	ISS	9039917	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00018	EGF receptor signaling pathway	P00550	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	15210125	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00053	T cell activation	P01324	rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00059	p53 pathway	P04634	Cdc2	TAKRU|Ensembl=ENSTRUG00000003059|UniProtKB=H2S418	Uncharacterized protein	ISS			PTHR24056:SF334	CYCLIN-DEPENDENT KINASE 1
P05918	p38 MAPK pathway	P06041	Cdc42	MACMU|Ensembl=ENSMMUG00000022009|UniProtKB=F6RBZ7	Cell division control protein 42 homolog isoform 2	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	IC	2372396	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01158	PDGF receptor A	MACMU|Ensembl=ENSMMUG00000015707|UniProtKB=F6SLY4	Platelet-derived growth factor receptor alpha	RCA			PTHR24416:SF52	PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=1339712|UniProtKB=P13542	Myosin-8	IC	10938134	PubMed	PTHR13140:SF368	MYOSIN-8
P04398	p53 pathway feedback loops 2	P04665	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	8836152	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CRYNJ|EnsemblGenome=CND03830|UniProtKB=Q5KI86	Uncharacterized protein	IC	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00034	Integrin signalling pathway	P00951	Jnk	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	IDA	10514528	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	ARATH|TAIR=AT5G07880|UniProtKB=Q9SD96	SNAP25 homologous protein SNAP29	ISS			PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02734	Chorismate biosynthesis	P02872	3-Dehydroquinate synthase	NEUCR|EnsemblGenome=EFNCRG00000005265|UniProtKB=Q7RW62	Repressor protein	ISS			PTHR21090:SF17	SUBFAMILY NOT NAMED
P00010	B cell activation	P00376	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P00052	TGF-beta signaling pathway	P01275	P38	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	TAS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	IDA	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00034	Integrin signalling pathway	P00944	Actin	DICDI|dictyBase=DDB_G0275023|UniProtKB=Q553U6	Putative actin-22	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00060	Ubiquitin proteasome pathway	P01491	E2	CANLF|Ensembl=ENSCAFG00000015961|UniProtKB=E2R6W9	Uncharacterized protein	ISS			PTHR44020:SF2	UBIQUITIN-CONJUGATING ENZYME E2 K
P00019	Endothelin signaling pathway	P00567	PKG	CAEEL|WormBase=WBGene00001173|UniProtKB=O76360	cGMP-dependent protein kinase egl-4	IGI	22458679	PubMed	PTHR24353:SF108	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CAEEL|WormBase=WBGene00002187|UniProtKB=O44408	GLH-binding kinase 1	ISS			PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00034	Integrin signalling pathway	P00925	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00012	Cadherin signaling pathway	P00474	Wnt	BRAFL|Gene=BRAFLDRAFT_56711|UniProtKB=C3XPR5	Protein Wnt	IDA	8717036	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00029	Huntington disease	P00774	Dynein complex	BOVIN|Ensembl=ENSBTAG00000014700|UniProtKB=Q2KII9	Dynein, cytoplasmic 1, light intermediate chain 1	ISS	9454836	PubMed	PTHR12688:SF2	CYTOPLASMIC DYNEIN 1 LIGHT INTERMEDIATE CHAIN 1
P00045	Notch signaling pathway	P01099	Notch	CANLF|Ensembl=ENSCAFG00000010476|UniProtKB=F1PS94	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00029	Huntington disease	P00775	Rac	ANOGA|EnsemblGenome=AGAP001573|UniProtKB=Q380U3	AGAP001573-PA	ISS			PTHR24072:SF157	AT17867P
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MACMU|Ensembl=ENSMMUG00000028733|UniProtKB=F6ZGX8	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF245	RAS-RELATED PROTEIN R-RAS
P00025	Hedgehog signaling pathway	P00685	Smoothened	PANTR|Ensembl=ENSPTRG00000019680|UniProtKB=H2QVC7	Uncharacterized protein	ISS	10021362	PubMed	PTHR11309:SF35	SMOOTHENED HOMOLOG
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P02759	Pyridoxal-5-phosphate biosynthesis	P03061	Pyridoxine-5-phosphate oxidase	ECOLI|EcoGene=EG11487|UniProtKB=P0AFI7	Pyridoxine/pyridoxamine 5'-phosphate oxidase	ISS	11786019	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	IC	15621031	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00970	Interleukin	HUMAN|HGNC=6023|UniProtKB=P13232	Interleukin-7	IDA	2643102	PubMed	PTHR45542:SF1	INTERLEUKIN-7
P02747	Histidine biosynthesis	P02991	Histidinephosphate aminotransferase	ECOLI|EcoGene=EG10446|UniProtKB=P06986	Histidinol-phosphate aminotransferase	ISS			PTHR42885:SF2	HISTIDINOL-PHOSPHATE AMINOTRANSFERASE
P00034	Integrin signalling pathway	P00906	Rap1	HUMAN|HGNC=30290|UniProtKB=Q9NZQ0	DnaJ homolog subfamily C member 27	IPI			PTHR24073:SF269	DNAJ HOMOLOG SUBFAMILY C MEMBER 27
P00048	PI3 kinase pathway	P01196	PDK1	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	PANTR|Ensembl=ENSPTRG00000014748|UniProtKB=H2QMA4	Uncharacterized protein	ISS	10209034	PubMed	PTHR23220:SF69	INTEGRIN ALPHA-9
P04395	Vasopressin synthesis	P04596	Endo Peptidase	CANLF|Ensembl=ENSCAFG00000003653|UniProtKB=F1PHX2	Uncharacterized protein	ISS	9695945	PubMed	PTHR42881:SF2	PROLYL ENDOPEPTIDASE
P04393	Ras Pathway	P04569	Cdc42	HUMAN|HGNC=1736|UniProtKB=P60953	Cell division control protein 42 homolog	IDA	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00034	Integrin signalling pathway	P00907	ERK	CANLF|Ensembl=ENSCAFG00000015640|UniProtKB=E2QVF3	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00052	TGF-beta signaling pathway	P01281	SARA	PANTR|Ensembl=ENSPTRG00000017038|UniProtKB=H2QR58	Uncharacterized protein	ISS			PTHR22835:SF43	ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 16
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	HUMAN|HGNC=4597|UniProtKB=P41594	Metabotropic glutamate receptor 5	IDA	8314195	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	14744428	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00005	Angiogenesis	P00237	FRP	CHICK|Ensembl=ENSGALG00000006944|UniProtKB=F1NHI6	Uncharacterized protein	ISS	10960783	PubMed	PTHR11309:SF12	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00774	Dynein complex	CHICK|Ensembl=ENSGALG00000007153|UniProtKB=F6UQS5	Uncharacterized protein	ISS	9454836	PubMed	PTHR11886:SF62	DYNEIN, LIGHT CHAIN, LC8-TYPE 2
P00046	Oxidative stress response	P01131	MKP5	PLAF7|EnsemblGenome=PFC0380w|UniProtKB=O77334	Dual specificity protein phosphatase	ISS			PTHR10159:SF402	DUAL SPECIFICITY PROTEIN PHOSPHATASE 19
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00060	Ubiquitin proteasome pathway	P01491	E2	DANRE|ZFIN=ZDB-GENE-030131-2977|UniProtKB=F1QRD9	Uncharacterized protein	ISS	10888878	PubMed	PTHR24068:SF116	AT26201P-RELATED
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MONDO|Ensembl=ENSMODG00000018065|UniProtKB=F7G485	Uncharacterized protein	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00022	General transcription by RNA polymerase I	P00650	TAF-IB	BOVIN|Ensembl=ENSBTAG00000011339|UniProtKB=A7MAZ4	Transcription initiation factor TFIID subunit 8	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00009	Axon guidance mediated by netrin	P00357	Netrin	HUMAN|HGNC=13658|UniProtKB=Q9HB63	Netrin-4	ISS	2538453	PubMed	PTHR10574:SF282	NETRIN-4
P00034	Integrin signalling pathway	P00951	Jnk	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	IDA	10851062	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	CHLRE|EnsemblGenome=CHLREDRAFT_133971|UniProtKB=A8I305	Glutamine synthetase	ISS			PTHR20852:SF79	GLUTAMINE SYNTHETASE CYTOSOLIC ISOZYME 1-1-RELATED
P00021	FGF signaling pathway	P00629	PP2A	XENTR|Xenbase=XB-GENE-946380|UniProtKB=Q0D2F4	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform	ISS	12716901	PubMed	PTHR11871:SF1	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B BETA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00012	Cadherin signaling pathway	P00474	Wnt	DANRE|ZFIN=ZDB-GENE-990603-12|UniProtKB=O73864	Protein Wnt-11	IDA	8717036	PubMed	PTHR12027:SF34	PROTEIN WNT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	MOUSE|MGI=MGI=1934950|UniProtKB=Q8BK63	Casein kinase I isoform alpha	ISS	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P04398	p53 pathway feedback loops 2	P04657	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IDA	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	SCHMA|EnsemblGenome=Smp_161920|UniProtKB=G4VSW5	Putative actin	ISS	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00059	p53 pathway	P04630	PP2A	TAKRU|Ensembl=ENSTRUG00000008018|UniProtKB=H2T5N4	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	DAPPU|EnsemblGenome=DAPPUDRAFT_302845|UniProtKB=E9GER1	Putative uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	IC	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04393	Ras Pathway	P04559	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05913	Enkephalin release	P05977	G-Protein (s)	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00018	EGF receptor signaling pathway	P00564	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	4757952	gi	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DANRE|ZFIN=ZDB-GENE-040625-35|UniProtKB=Q6IQL9	Novel actin protein	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00227	PLA2	CANLF|Ensembl=ENSCAFG00000013778|UniProtKB=F6UQ33	Phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00036	Interleukin signaling pathway	P00975	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00021	FGF signaling pathway	P00634	MEKK1-5	BOVIN|Ensembl=ENSBTAG00000020079|UniProtKB=F1N3T0	Uncharacterized protein	ISS	12052864	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00019	Endothelin signaling pathway	P00591	PLCbeta	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	TRIAD|EnsemblGenome=TriadG63380|UniProtKB=B3S653	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P04609	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00807	Actin	SCLS1|Gene=SS1G_08733|UniProtKB=A7ETS6	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	PANTR|Ensembl=ENSPTRG00000020122|UniProtKB=H2QVZ0	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF22	FRIZZLED-3
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00566	ERK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	NAS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00554	Shc	CANLF|Ensembl=ENSCAFG00000002201|UniProtKB=F1PPW0	Uncharacterized protein	ISS	96330343	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BOVIN|Ensembl=ENSBTAG00000005714|UniProtKB=Q3ZC07	Actin, alpha cardiac muscle 1	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	XENTR|Xenbase=XB-GENE-491433|UniProtKB=B1H2U0	Pten protein	ISS	10555148	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04393	Ras Pathway	P04568	MKK3/6	BOVIN|Ensembl=ENSBTAG00000010576|UniProtKB=A4IFH7	MAP2K3 protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00036	Interleukin signaling pathway	P00981	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05730	Endogenous cannabinoid signaling	P05751	Galpha	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04398	p53 pathway feedback loops 2	P04665	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00547	PP2A	CHICK|Ensembl=ENSGALG00000009828|UniProtKB=E1C5A3	Uncharacterized protein	ISS	12110603	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P04395	Vasopressin synthesis	P04589	Signal Peptidase	MOUSE|MGI=MGI=1923469|UniProtKB=Q9D365	Signal peptidase complex subunit 3	IC	1546959	PubMed	PTHR12804:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04452	proopiomelanocortin	DANRE|ZFIN=ZDB-GENE-030513-2|UniProtKB=Q7ZT18	Pro-opiomelanocortin protein	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	CANLF|Ensembl=ENSCAFG00000015213|UniProtKB=E2RB82	Signal transducer and activator of transcription	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00004	Alzheimer disease-presenilin pathway	P00123	CD44 C-terminal fragment	HUMAN|HGNC=1681|UniProtKB=P16070	CD44 antigen	IDA	12223485	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05918	p38 MAPK pathway	P06031	p38alpha	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CAEBR|Gene=CBG18112|UniProtKB=A8XT20	Protein CBR-GLR-1	ISS	12941441	PubMed	PTHR18966:SF297	GLUTAMATE RECEPTOR 1
P00056	VEGF signaling pathway	P01417	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	BOVIN|Gene=MMP13|UniProtKB=O77656	Collagenase 3	TAS	8207000	PubMed	PTHR10201:SF165	COLLAGENASE 3
P00052	TGF-beta signaling pathway	P01284	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02738	De novo purine biosynthesis	P02905	Amidophosphoribosyl transferase	METJA|EnsemblGenome=MJ_0204|UniProtKB=Q57657	Amidophosphoribosyltransferase	ISS			PTHR11907:SF0	AMIDOPHOSPHORIBOSYLTRANSFERASE
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	IC	1482697	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00005	Angiogenesis	P00219	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MACMU|Ensembl=ENSMMUG00000019305|UniProtKB=F6S3T8	Ribosomal protein S6 kinase	ISS	11861821	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00005	Angiogenesis	P00226	Delta/Serrate	MONDO|Ensembl=ENSMODG00000004910|UniProtKB=F7C1Q4	Delta-like protein	ISS	1286675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00053	T cell activation	P01322	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00018	EGF receptor signaling pathway	P00546	GAP	CANLF|Ensembl=ENSCAFG00000018592|UniProtKB=F1PIZ0	Uncharacterized protein	ISS	95047432	PubMed	PTHR10194:SF60	NEUROFIBROMIN
P00010	B cell activation	P00373	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00007	Axon guidance mediated by semaphorins	P00331	PAK	MACMU|Ensembl=ENSMMUG00000001387|UniProtKB=F7D0B4	Uncharacterized protein	ISS	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	RAT|RGD=621516|UniProtKB=G3V6P8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00036	Interleukin signaling pathway	P00968	Ikk	BOVIN|Ensembl=ENSBTAG00000007599|UniProtKB=Q95KV0	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00035	Interferon-gamma signaling pathway	P00954	Interferongamma	HUMAN|HGNC=5438|UniProtKB=P01579	Interferon gamma	TAS	11175845	PubMed	PTHR11419:SF0	INTERFERON GAMMA
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Gene=GRIK4|UniProtKB=Q5IS46	Glutamate receptor ionotropic, kainate 4	ISS	11319238	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00045	Notch signaling pathway	P01104	Serrate	RAT|RGD=2937|UniProtKB=Q63722	Protein jagged-1	IDA	7697721	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00021	FGF signaling pathway	P00624	14-3-3	XENTR|Xenbase=XB-GENE-970616|UniProtKB=Q6P4Z5	14-3-3 protein zeta	ISS	12861023	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	ANOGA|EnsemblGenome=AGAP004362|UniProtKB=F5HLM0	AGAP004362-PF	ISS			PTHR11606:SF13	GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL
P00054	Toll receptor signaling pathway	P01375	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05913	Enkephalin release	P05972	PKA	STRPU|EnsemblGenome=SPU_018419|UniProtKB=W4YRI6	Uncharacterized protein	ISS	97210759	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	RAT|RGD=1311985|UniProtKB=B2GV73	Actin-related protein 2/3 complex subunit 3	ISS	9359840	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00059	p53 pathway	G01579	PTEN	XENTR|Xenbase=XB-GENE-491433|UniProtKB=B1H2U0	Pten protein	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00019	Endothelin signaling pathway	P00566	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P02723	Adenine and hypoxanthine salvage pathway	P02810	Adenine phosphoribosyl transferase	STRCO|EnsemblGenome=CAB70916|UniProtKB=P52561	Adenine phosphoribosyltransferase	ISS			PTHR32315:SF3	ADENINE PHOSPHORIBOSYLTRANSFERASE
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P02736	Coenzyme A biosynthesis	P02886	Pantetheine-phosphate adenyltransferase	BACSU|EnsemblGenome=BSU15020|UniProtKB=O34797	Phosphopantetheine adenylyltransferase	ISS			PTHR21342:SF1	PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00046	Oxidative stress response	P01138	MKK4	BOVIN|Ensembl=ENSBTAG00000012103|UniProtKB=A5PJP8	MAP2K4 protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	HUMAN|HGNC=10935|UniProtKB=Q05940	Synaptic vesicular amine transporter	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00137	Tip60	BOVIN|Ensembl=ENSBTAG00000005578|UniProtKB=E1BMS5	Histone acetyltransferase	ISS	11441186	PubMed	PTHR10615:SF124	HISTONE ACETYLTRANSFERASE KAT5
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	HUMAN|HGNC=8528|UniProtKB=P01178	Oxytocin-neurophysin 1	ISS	9756087	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00057	Wnt signaling pathway	P01465	Ggamma	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00189	Fzd	CHICK|Gene=FZD1|UniProtKB=O57328	Frizzled-1	ISS	8717036	PubMed	PTHR11309:SF81	FRIZZLED-1
P00019	Endothelin signaling pathway	P00586	Gq	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IGI	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02755	Methylmalonyl pathway	P03034	Methylmalonyl-CoA mutase	MONDO|Ensembl=ENSMODG00000018855|UniProtKB=F7DW04	Uncharacterized protein	ISS			PTHR42710:SF1	METHYLMALONYL-COA MUTASE, MITOCHONDRIAL
P00011	Blood coagulation	P00416	Prothrombin	MOUSE|MGI=MGI=88380|UniProtKB=P19221	Prothrombin	ISS	+176930	OMIM	PTHR24254:SF10	PROTHROMBIN
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	RAT|RGD=2343|UniProtKB=P08483	Muscarinic acetylcholine receptor M3	TAS	10069496	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P04393	Ras Pathway	P04559	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02757	O-antigen biosynthesis	P03047	dTDP-4-dehydrorhamnose 3,5-epimerase	LEPIN|EnsemblGenome=LA_1659|UniProtKB=G1UB27	dTDP-4-dehydrorhamnose 3,5-epimerase	ISS			PTHR21047:SF2	DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	CAEEL|WormBase=WBGene00000390|UniProtKB=Q05062	Cell division control protein 42 homolog	ISS			PTHR24072:SF192	CDC42 HOMOLOG
P00012	Cadherin signaling pathway	P00474	Wnt	MONDO|Ensembl=ENSMODG00000013810|UniProtKB=F6SXE3	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P00034	Integrin signalling pathway	P00924	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00796	Kainate receptor	HUMAN|HGNC=4579|UniProtKB=P39086	Glutamate receptor ionotropic, kainate 1	IDA	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00029	Huntington disease	P00790	beta-Tubulin	CHICK|Ensembl=ENSGALG00000026802|UniProtKB=G1K338	Uncharacterized protein	TAS	12932731	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P00029	Huntington disease	P00778	NMDA receptor	HUMAN|HGNC=4587|UniProtKB=Q14957	Glutamate receptor ionotropic, NMDA 2C	IDA	11554549	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00049	Parkinson disease	P01219	SAPK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00019	Endothelin signaling pathway	P00589	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	NAS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00558	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=1921305|UniProtKB=Q8K4S1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	12860966	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P06587	Nicotine pharmacodynamics pathway	P06590	GNG	XENTR|Xenbase=XB-GENE-961282|UniProtKB=Q6DF43	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P05912	Dopamine receptor mediated signaling pathway	P05951	CDK5	MACMU|Ensembl=ENSMMUG00000020451|UniProtKB=F6VZU3	Uncharacterized protein	ISS	10604473	PubMed	PTHR24056:SF46	CYCLIN-DEPENDENT-LIKE KINASE 5
P00006	Apoptosis signaling pathway	P00317	Fos	MACMU|Ensembl=ENSMMUG00000010574|UniProtKB=A5A6H2	C-fos	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00034	Integrin signalling pathway	P00944	Actin	PUCGT|EnsemblGenome=PGTG_05488|UniProtKB=E3K4I1	Actin	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ORYSJ|EnsemblGenome=OS11G0163100|UniProtKB=Q67G20	Actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02785	Valine biosynthesis	P03218	Dihydroxy isovalerate dehydratase	DEIRA|EnsemblGenome=DR_1132|UniProtKB=Q9RV97	Dihydroxy-acid dehydratase	ISS			PTHR43661:SF3	DIHYDROXY-ACID DEHYDRATASE
P00010	B cell activation	P00375	Calmodulin	ORYSJ|EnsemblGenome=OS05G0491100|UniProtKB=Q6F332	Calmodulin-2	ISS	10487978	PubMed	PTHR23050:SF324	CALMODULIN-2-RELATED
P00053	T cell activation	P01331	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IDA	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05917	Opioid proopiomelanocortin pathway	P06006	beta-Endorphin	BOVIN|Ensembl=ENSBTAG00000007897|UniProtKB=P01190	Pro-opiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DANRE|ZFIN=ZDB-GENE-040426-1489|UniProtKB=Q6PHV0	Syntaxin 3A	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00053	T cell activation	P01300	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01457	GBeta	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IDA	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	MONDO|Ensembl=ENSMODG00000011192|UniProtKB=F6SRK5	Uncharacterized protein	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P02778	Sulfate assimilation	P03167	Sulfate adenylyltransferase	ARATH|TAIR=AT3G22890|UniProtKB=Q9LIK9	ATP sulfurylase 1, chloroplastic	ISS			PTHR11055:SF18	ATP SULFURYLASE 1, CHLOROPLASTIC-RELATED
P00034	Integrin signalling pathway	P00910	Grb2	MOUSE|MGI=MGI=1918770|UniProtKB=Q9CX99	GRB2-related adapter protein	ISS	9741627	PubMed	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P02738	De novo purine biosynthesis	P02891	GDP kinase	DANRE|ZFIN=ZDB-GENE-000710-3|UniProtKB=Q6DI51	Nucleoside diphosphate kinase 6	ISS			PTHR11349:SF70	NUCLEOSIDE DIPHOSPHATE KINASE 6
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DANRE|ZFIN=ZDB-GENE-041001-104|UniProtKB=Q5TZD4	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P02738	De novo purine biosynthesis	P02902	ADP reductase	MONDO|Ensembl=ENSMODG00000008391|UniProtKB=F7A4H4	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00010	B cell activation	P00398	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05730	Endogenous cannabinoid signaling	P05746	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00012	Cadherin signaling pathway	P00470	F-actin	DANRE|ZFIN=ZDB-GENE-030131-172|UniProtKB=Q6IQR3	Actin, alpha, cardiac muscle 1a	IC	11889126	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00591	PLCbeta	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	IGI	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	YEAST|SGD=S000000050|UniProtKB=Q01574	Acetyl-coenzyme A synthetase 1	ISS			PTHR24095:SF14	ACETYL-COENZYME A SYNTHETASE 1
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IGI	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00047	PDGF signaling pathway	P01143	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00973	PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	IC	8838325	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00011	Blood coagulation	P00451	Kininogen	MOUSE|MGI=MGI=1097705|UniProtKB=O08677	Kininogen-1	ISS	12643495	gi	PTHR13814:SF12	KININOGEN-1
P00046	Oxidative stress response	P01138	MKK4	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00009	Axon guidance mediated by netrin	P00356	UNC-5	BOVIN|Ensembl=ENSBTAG00000002084|UniProtKB=F1MF29	Uncharacterized protein	ISS			PTHR12582:SF7	NETRIN RECEPTOR UNC5C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	TAKRU|Ensembl=ENSTRUG00000014763|UniProtKB=H2ULB2	Uncharacterized protein	ISS			PTHR13140:SF728	MYOSIN HEAVY CHAIN, SKELETAL MUSCLE, ADULT
P00059	p53 pathway	P04634	Cdc2	MACMU|Ensembl=ENSMMUG00000018817|UniProtKB=F6ZHC1	Uncharacterized protein	ISS	15660127	PubMed	PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P05734	Synaptic vesicle trafficking	P05774	NSF	HUMAN|HGNC=8016|UniProtKB=P46459	Vesicle-fusing ATPase	IDA	7969419	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00029	Huntington disease	P00767	Pro-caspase 8	RAT|RGD=620945|UniProtKB=Q9JHX4	Caspase-8	IDA	8681376	PubMed	PTHR10454:SF162	CASPASE-8
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00010	B cell activation	P00397	IKK	RAT|RGD=621375|UniProtKB=Q9QY78	Inhibitor of nuclear factor kappa-B kinase subunit beta	IGI	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00059	p53 pathway	P01486	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	TAS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00060	Ubiquitin proteasome pathway	P01492	E1	HUMAN|HGNC=25581|UniProtKB=A0AVT1	Ubiquitin-like modifier-activating enzyme 6	ISS			PTHR10953:SF186	UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 6
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IGI	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00010	B cell activation	P00367	NFAT	RAT|RGD=1307690|UniProtKB=D4A0I8	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (Predicted), isoform CRA_b	ISS	12015605	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	IDA	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MONDO|Ensembl=ENSMODG00000013079|UniProtKB=F7FB74	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00091	Aph-1	PANTR|Ensembl=ENSPTRG00000007146|UniProtKB=H2Q9J9	Anterior pharynx defective 1 homolog B	ISS	12763021	PubMed	PTHR12889:SF1	GAMMA-SECRETASE SUBUNIT APH-1B
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	HUMAN|HGNC=10437|UniProtKB=Q9UBS0	Ribosomal protein S6 kinase beta-2	ISS	15116068	PubMed	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00049	Parkinson disease	P01212	p38 MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00006	Apoptosis signaling pathway	P00260	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00059	p53 pathway	G04702	p53	CANLF|Ensembl=ENSCAFG00000013961|UniProtKB=F1PL57	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MONDO|Ensembl=ENSMODG00000012546|UniProtKB=F6PM16	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00008	Axon guidance mediated by Slit/Robo	P00351	Cxcr4	MACMU|Gene=CXCR4|UniProtKB=P79394	C-X-C chemokine receptor type 4	ISS	4503175	gi	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P04393	Ras Pathway	P04567	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IDA	12660731	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00012	Cadherin signaling pathway	P00474	Wnt	BRAFL|Gene=BRAFLDRAFT_113720|UniProtKB=C3YYJ8	Protein Wnt	IDA	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00052	TGF-beta signaling pathway	P01292	RSmads	DANRE|ZFIN=ZDB-GENE-000509-3|UniProtKB=Q8AY15	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF47	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	XENTR|Xenbase=XB-GENE-494200|UniProtKB=F7CS79	Uncharacterized protein	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00034	Integrin signalling pathway	P00948	Rho	BOVIN|Ensembl=ENSBTAG00000007393|UniProtKB=F1MUP6	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF21	RHO-RELATED GTP-BINDING PROTEIN RHON
P06959	CCKR signaling map	P07105	MMP3	HUMAN|HGNC=7173|UniProtKB=P08254	Stromelysin-1	RCA	14764442	PubMed	PTHR10201:SF215	STROMELYSIN-1
P00030	Hypoxia response via HIF activation	P00819	AKT	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	TAS	12719720	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	TAKRU|Ensembl=ENSTRUG00000016101|UniProtKB=H2UW32	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00010	B cell activation	P00397	IKK	MOUSE|MGI=MGI=99484|UniProtKB=Q60680	Inhibitor of nuclear factor kappa-B kinase subunit alpha	IGI	12235208	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00282	IGFR2	HUMAN|HGNC=5467|UniProtKB=P11717	Cation-independent mannose-6-phosphate receptor	IDA	11081635	PubMed	PTHR15071:SF17	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	HUMAN|HGNC=7849|UniProtKB=P15531	Nucleoside diphosphate kinase A	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MACMU|Ensembl=ENSMMUG00000010987|UniProtKB=F7GCX9	Uncharacterized protein	ISS	12497607	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00057	Wnt signaling pathway	P01438	PP2A	TAKRU|Ensembl=ENSTRUG00000003840|UniProtKB=H2S9H8	Uncharacterized protein	ISS	11007767	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00054	Toll receptor signaling pathway	P01375	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00036	Interleukin signaling pathway	P00996	STAT	HUMAN|HGNC=11367|UniProtKB=P51692	Signal transducer and activator of transcription 5B	IDA	95236292	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	TAS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	ISS	10704417	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_56698|UniProtKB=C3XYC3	Putative uncharacterized protein	IDA	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	MONDO|Ensembl=ENSMODG00000006559|UniProtKB=F7BUU3	Adenylosuccinate synthetase isozyme 2	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00029	Huntington disease	P00779	TBP	CAEEL|WormBase=WBGene00006542|UniProtKB=P32085	TATA-box-binding protein	IPI	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00049	Parkinson disease	P01227	20S proteasome	ARATH|TAIR=AT1G53850|UniProtKB=O81149	Proteasome subunit alpha type-5-A	ISS	12859888	PubMed	PTHR11599:SF14	PROTEASOME SUBUNIT ALPHA TYPE-5
P00011	Blood coagulation	P00429	PN2	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	ISS	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00056	VEGF signaling pathway	P01423	p38MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	BOVIN|Ensembl=ENSBTAG00000015150|UniProtKB=P54349	Interleukin-12 subunit alpha	ISS	11023671	PubMed	PTHR45311:SF1	INTERLEUKIN-12 SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01288	FKBP12	BOVIN|Ensembl=ENSBTAG00000032651|UniProtKB=Q2NKS8	Peptidyl-prolyl cis-trans isomerase	ISS			PTHR10516:SF301	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED
P00010	B cell activation	P00385	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	4757952	gi	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000015240|UniProtKB=F6VUY3	Uncharacterized protein	ISS	11431030	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04580	TRH Receptor	XENTR|Xenbase=XB-GENE-992328|UniProtKB=F6X115	Uncharacterized protein	ISS	14599121	PubMed	PTHR24243:SF115	THYROTROPIN-RELEASING HORMONE RECEPTOR
P02724	Alanine biosynthesis	P02815	Branched chain amino acid aminotransferase	NEUCR|Gene=NCU04292|UniProtKB=Q1K779	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF69	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00546	GAP	HUMAN|HGNC=7765|UniProtKB=P21359	Neurofibromin	ISS	8982875	PubMed	PTHR10194:SF60	NEUROFIBROMIN
P00021	FGF signaling pathway	P00640	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00729	Goalpha	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	IC	11035810	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01230	Src kinase	BOVIN|Ensembl=ENSBTAG00000020034|UniProtKB=F1N261	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00021	FGF signaling pathway	P00628	JNK1-3	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05913	Enkephalin release	P05976	Enkephalin	RAT|RGD=68946|UniProtKB=P04094	Proenkephalin-A	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00011	Blood coagulation	P00416	Prothrombin	BOVIN|Ensembl=ENSBTAG00000007148|UniProtKB=P00735	Prothrombin	ISS	163755	gi	PTHR24254:SF10	PROTHROMBIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	TAS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00048	PI3 kinase pathway	P01179	PKB	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00990	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00224	PDGF	HUMAN|HGNC=30620|UniProtKB=Q9GZP0	Platelet-derived growth factor D	IDA	12629513	PubMed	PTHR11633:SF4	PLATELET-DERIVED GROWTH FACTOR D
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00047	PDGF signaling pathway	P01162	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	94313981	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	TAS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DROME|FlyBase=FBgn0000047|UniProtKB=P83967	Actin, indirect flight muscle	IC	14684598	PubMed	PTHR11937:SF368	ACTIN, INDIRECT FLIGHT MUSCLE
P00025	Hedgehog signaling pathway	P00692	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04665	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Gene=ADORA2B|UniProtKB=Q6W3F4	Adenosine receptor A2b	ISS			PTHR24246:SF18	ADENOSINE RECEPTOR A2B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P02781	Threonine biosynthesis	P03192	Aspartate semialdehyde dehydrogenase	THEMA|EnsemblGenome=TM_1523|UniProtKB=Q9X1L1	Aspartate-semialdehyde dehydrogenase	ISS			PTHR10174:SF2	ASPARTATE-SEMIALDEHYDE DEHYDROGENASE
P00029	Huntington disease	P00807	Actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	IDA	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00057	Wnt signaling pathway	P01466	Diversin	MOUSE|MGI=MGI=2154278|UniProtKB=Q69ZU8	Ankyrin repeat domain-containing protein 6	IDA	12183362	PubMed	PTHR24203:SF7	ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 6
P00009	Axon guidance mediated by netrin	P00363	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00761	Truncated Htt	HUMAN|HGNC=4851|UniProtKB=P42858	Huntingtin	TAS	7620118	PubMed	PTHR10170:SF10	HUNTINGTIN
P00029	Huntington disease	P00807	Actin	RAT|RGD=1310826|UniProtKB=Q5M7U6	Actin-related protein 2	ISS	11889126	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00471	Cadherin	CHICK|Gene=CDH10|UniProtKB=P79995	Cadherin-10	IDA	8120095	PubMed	PTHR24027:SF290	CADHERIN-10
P00047	PDGF signaling pathway	P01173	STAT	XENTR|Xenbase=XB-GENE-482166|UniProtKB=F6UJK9	Signal transducer and activator of transcription	ISS	102582	OMIM	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00029	Huntington disease	P00807	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g169611|UniProtKB=A7SEB1	Predicted protein	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=4404|UniProtKB=P59768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00018	EGF receptor signaling pathway	P00557	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	MOUSE|MGI=MGI=1321161|UniProtKB=P62715	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01434	sFRP	HUMAN|HGNC=10777|UniProtKB=Q96HF1	Secreted frizzled-related protein 2	ISS	9096311	PubMed	PTHR11309:SF45	SECRETED FRIZZLED-RELATED PROTEIN 2
P04397	p53 pathway by glucose deprivation	P04641	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04633	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00024	Glycolysis	P00678	Enolase	CHICK|Gene=ENO1|UniProtKB=P51913	Alpha-enolase	ISS	89079778	PubMed	PTHR11902:SF12	ALPHA-ENOLASE
P00036	Interleukin signaling pathway	P00973	PKB	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	IDA	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P02747	Histidine biosynthesis	P02985	Histidinol dehydrogenase	METAC|EnsemblGenome=MA_3201|UniProtKB=Q8TL41	Histidinol dehydrogenase	ISS			PTHR21256:SF2	HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	MACMU|Ensembl=ENSMMUG00000007605|UniProtKB=F6SJQ8	Uncharacterized protein	ISS	94365697	PubMed	PTHR11958:SF22	EXCITATORY AMINO ACID TRANSPORTER 5
P00005	Angiogenesis	P00186	FGFR-1	CANLF|Ensembl=ENSCAFG00000005970|UniProtKB=E2R186	Fibroblast growth factor receptor	ISS	9763444	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P04398	p53 pathway feedback loops 2	P04665	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	TAKRU|Ensembl=ENSTRUG00000014318|UniProtKB=H2UI49	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00057	Wnt signaling pathway	P01446	Calcineurin	CANLF|Ensembl=ENSCAFG00000014818|UniProtKB=E2RJ59	Serine/threonine-protein phosphatase	ISS	12015605	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	TAS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	IPI	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	RAT|RGD=620967|UniProtKB=F1M9D0	Protein Map3k2	ISS	8649450	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00059	p53 pathway	P04633	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00059	p53 pathway	G04689	Cyclin G	MACMU|Ensembl=ENSMMUG00000019550|UniProtKB=F7CKQ1	Uncharacterized protein	ISS	11983168	PubMed	PTHR10177:SF59	CYCLIN-G1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MACMU|Ensembl=ENSMMUG00000004886|UniProtKB=F7AGT9	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00005	Angiogenesis	P00211	GSK3beta	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01408	Akt/PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	THEMA|EnsemblGenome=TM_1096|UniProtKB=Q9X0I1	Adenylosuccinate synthetase	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	IC	188830	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00273	p53	HUMAN|HGNC=11998|UniProtKB=P04637	Cellular tumor antigen p53	IDA	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000017387|UniProtKB=E2RLD1	Uncharacterized protein	ISS	129387	gi	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	BOVIN|Ensembl=ENSBTAG00000004775|UniProtKB=F1MBY1	Uncharacterized protein	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	PANTR|Ensembl=ENSPTRG00000010952|UniProtKB=H2Q960	Uncharacterized protein	ISS			PTHR24361:SF182	SERINE/THREONINE-PROTEIN KINASE PAK 6
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00046	Oxidative stress response	P01131	MKP5	MACMU|Ensembl=ENSMMUG00000013732|UniProtKB=F6RW93	Dual specificity protein phosphatase 26	ISS			PTHR10159:SF112	DUAL SPECIFICITY PROTEIN PHOSPHATASE 26
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00054	Toll receptor signaling pathway	P01369	MKK1	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	94313981	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05730	Endogenous cannabinoid signaling	P05746	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00019	Endothelin signaling pathway	P00589	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	DEIRA|EnsemblGenome=DR_2177|UniProtKB=Q9RSE7	Cytidine deaminase	ISS			PTHR11644:SF2	CYTIDINE DEAMINASE
P05913	Enkephalin release	P05978	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	DANRE|ZFIN=ZDB-GENE-070112-342|UniProtKB=A1L271	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04398	p53 pathway feedback loops 2	P04653	cdk2	PANTR|Ensembl=ENSPTRG00000005070|UniProtKB=H2Q670	Cyclin-dependent kinase 2	ISS	1846803	PubMed	PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01153	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00012	Cadherin signaling pathway	P00470	F-actin	CANLF|Ensembl=ENSCAFG00000016020|UniProtKB=O18840	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P02783	Tryptophan biosynthesis	P03207	Tryptophan synthase A	DEIRA|EnsemblGenome=DR_0942|UniProtKB=Q9RVT0	Tryptophan synthase alpha chain	ISS			PTHR43406:SF1	TRYPTOPHAN SYNTHASE ALPHA CHAIN
P06959	CCKR signaling map	G06987	PAI1	HUMAN|HGNC=8583|UniProtKB=P05121	Plasminogen activator inhibitor 1	RCA	21193525	PubMed	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	TAS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	LEIMA|EnsemblGenome=LmjF.18.1080|UniProtKB=Q27687	Protein kinase A catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00186	FGFR-1	ORNAN|Ensembl=ENSOANG00000003252|UniProtKB=F6SM70	Fibroblast growth factor receptor	ISS	9763444	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P02778	Sulfate assimilation	P03167	Sulfate adenylyltransferase	ANOGA|EnsemblGenome=AGAP001256|UniProtKB=F5HMV2	AGAP001256-PC	ISS			PTHR11055:SF1	PAPS SYNTHETASE, ISOFORM D
P00018	EGF receptor signaling pathway	P00562	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IGI	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	IDA	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00056	VEGF signaling pathway	P01425	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00048	PI3 kinase pathway	P01198	FOXO	MACMU|Ensembl=ENSMMUG00000020369|UniProtKB=F6UMX8	Uncharacterized protein	ISS	14775847	gi	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01437	TCF	HUMAN|HGNC=11640|UniProtKB=Q9HCS4	Transcription factor 7-like 1	IDA	9118222	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	DANRE|ZFIN=ZDB-GENE-050417-66|UniProtKB=Q568H8	Uncharacterized protein	ISS	606023	OMIM	PTHR10917:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3
P00036	Interleukin signaling pathway	P00973	PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT1G10210|UniProtKB=Q39021	Mitogen-activated protein kinase 1	ISS	94177172	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00047	PDGF signaling pathway	P01143	ERK	CHICK|Ensembl=ENSGALG00000004690|UniProtKB=Q5F3W3	Mitogen-activated protein kinase 6	ISS	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00053	T cell activation	P01322	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IGI	12707323	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00057	Wnt signaling pathway	P01428	Frizzled	BOVIN|Ensembl=ENSBTAG00000002283|UniProtKB=F1N4K7	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF31	FRIZZLED-7
P00039	Metabotropic glutamate receptor group III pathway	P01038	Vglut	CANLF|Ensembl=ENSCAFG00000003665|UniProtKB=F6Y4M4	Uncharacterized protein	ISS	15192755	PubMed	PTHR11662:SF138	VESICULAR GLUTAMATE TRANSPORTER 1
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00047	PDGF signaling pathway	P01156	PDGF receptor B	MACMU|Ensembl=ENSMMUG00000011557|UniProtKB=F7BTH1	Platelet-derived growth factor receptor beta	RCA			PTHR24416:SF53	PLATELET-DERIVED GROWTH FACTOR RECEPTOR BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=11334|UniProtKB=P35346	Somatostatin receptor type 5	IDA	12562507	PubMed	PTHR24229:SF20	SOMATOSTATIN RECEPTOR TYPE 5
P00049	Parkinson disease	P01242	Casein kinase I	MOUSE|MGI=MGI=1934950|UniProtKB=Q8BK63	Casein kinase I isoform alpha	IDA	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00010	B cell activation	P00383	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	IDA	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	HUMAN|HGNC=6551|UniProtKB=Q9UJU2	Lymphoid enhancer-binding factor 1	TAS	9039917	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P04393	Ras Pathway	P04557	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04376	5HT4 type receptor mediated signaling pathway	P04427	5HT4 Receptor	BOVIN|Ensembl=ENSBTAG00000010837|UniProtKB=F1N3N9	Uncharacterized protein	ISS	12181435	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CRYNJ|EnsemblGenome=CNA05510|UniProtKB=Q5KNS1	cAMP-dependent protein kinase regulatory subunit	ISS	11287622	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	TAS			PTHR24055:SF330	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P05915	Opioid proenkephalin pathway	P05994	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	P00543	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	DROME|FlyBase=FBgn0000039|UniProtKB=P17644	Acetylcholine receptor subunit alpha-like 2	IC	85270494	PubMed	PTHR18945:SF430	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-LIKE 2
P00034	Integrin signalling pathway	P00906	Rap1	CHICK|Ensembl=ENSGALG00000001476|UniProtKB=F1NSA8	Uncharacterized protein	ISS	8576107	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00053	T cell activation	P01324	rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	10802295	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00269	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04397	p53 pathway by glucose deprivation	P04644	TSC2	TAKRU|Ensembl=ENSTRUG00000008958|UniProtKB=H2TCY4	Uncharacterized protein	ISS	12150915	PubMed	PTHR10063:SF0	TUBERIN
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00004	Alzheimer disease-presenilin pathway	P00115	Nicastrin	CAEEL|WormBase=WBGene00000148|UniProtKB=Q23316	Nicastrin	IDA	16096062	PubMed	PTHR21092:SF0	NICASTRIN
P00034	Integrin signalling pathway	P00923	Arf1	MONDO|Ensembl=ENSMODG00000013804|UniProtKB=F6SY88	Uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF294	ADP-RIBOSYLATION FACTOR 3
P00006	Apoptosis signaling pathway	P00269	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00561	STAT	MONDO|Ensembl=ENSMODG00000014836|UniProtKB=F7D2D3	Signal transducer and activator of transcription	ISS	95236292	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00017	DNA replication	P00528	Primase	BOVIN|Ensembl=ENSBTAG00000044000|UniProtKB=G8JKZ3	DNA primase	ISS	10441007	PubMed	PTHR10536:SF0	DNA PRIMASE SMALL SUBUNIT
P00038	JAK/STAT signaling pathway	P01031	PIAS	BOVIN|Ensembl=ENSBTAG00000007833|UniProtKB=F1MMY9	Uncharacterized protein	ISS	8682149	PubMed	PTHR10782:SF12	E3 SUMO-PROTEIN LIGASE PIAS2
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04397	p53 pathway by glucose deprivation	P04636	S6K	CHICK|Ensembl=ENSGALG00000005198|UniProtKB=F1P4J0	Ribosomal protein S6 kinase	IDA	15116068	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00015	Circadian clock system	P00505	Cry	DANRE|ZFIN=ZDB-GENE-010426-2|UniProtKB=A4QN37	Cry1a protein	ISS			PTHR11455:SF27	CRY1A PROTEIN
P00053	T cell activation	P01324	rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00021	FGF signaling pathway	P00644	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00048	PI3 kinase pathway	P01181	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04393	Ras Pathway	P04543	MEKK1/4	HUMAN|HGNC=6856|UniProtKB=Q9Y6R4	Mitogen-activated protein kinase kinase kinase 4	IDA	9305639	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00013	Cell cycle	P00481	APC	DANRE|ZFIN=ZDB-GENE-060224-2|UniProtKB=E7FCJ1	Anaphase-promoting complex subunit 10	ISS	14732115	gi	PTHR12936:SF0	ANAPHASE-PROMOTING COMPLEX SUBUNIT 10
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IDA	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00007	Axon guidance mediated by semaphorins	P00341	Rho	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	ISS	11360179	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MACMU|Ensembl=ENSMMUG00000004886|UniProtKB=F7AGT9	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00047	PDGF signaling pathway	P01142	p90RSK	CHICK|Ensembl=ENSGALG00000016406|UniProtKB=F1NLJ3	Uncharacterized protein	ISS	10558991	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00005	Angiogenesis	P00235	c-Fos	MACMU|Ensembl=ENSMMUG00000010574|UniProtKB=A5A6H2	C-fos	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	IC	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00036	Interleukin signaling pathway	P00965	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	IC	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00049	Parkinson disease	P01208	Hsp70	PANTR|Ensembl=ENSPTRG00000004404|UniProtKB=H2Q500	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF239	HEAT SHOCK COGNATE 71 KDA PROTEIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000020588|UniProtKB=F7C0E0	Uncharacterized protein	ISS	10644715	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00018	EGF receptor signaling pathway	P00565	PKC	SCHPO|PomBase=SPBC12D12.04c|UniProtKB=P36583	Protein kinase C-like 2	IGI	8491190	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MOUSE|MGI=MGI=1928896|UniProtKB=Q9R0Q6	Actin-related protein 2/3 complex subunit 1A	ISS	12963527	gi	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00049	Parkinson disease	P01235	Fyn kinase	HUMAN|HGNC=4037|UniProtKB=P06241	Tyrosine-protein kinase Fyn	IDA	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00047	PDGF signaling pathway	P01171	PLCgamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00021	FGF signaling pathway	P00628	JNK1-3	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00219	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00638	PLCgamma	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00018	EGF receptor signaling pathway	P00565	PKC	NEUCR|EnsemblGenome=EFNCRG00000006341|UniProtKB=P87253	Protein kinase C-like	ISS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	RAT|RGD=2345|UniProtKB=P04757	Neuronal acetylcholine receptor subunit alpha-3	ISS	85270494	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00092	TACE	CANLF|Ensembl=ENSCAFG00000003383|UniProtKB=F1PFZ9	Uncharacterized protein	ISS	12834808	PubMed	PTHR11905:SF171	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	MACMU|Ensembl=ENSMMUG00000010031|UniProtKB=F6Q193	TGF-beta receptor type-2	ISS	9395284	PubMed	PTHR23255:SF55	TGF-BETA RECEPTOR TYPE-2
P00012	Cadherin signaling pathway	P00471	Cadherin	DROME|FlyBase=FBgn0001075|UniProtKB=P33450	Cadherin-related tumor suppressor	IDA	8120095	PubMed	PTHR24026:SF69	PROTOCADHERIN FAT 4
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	RAT|RGD=619966|UniProtKB=F1LQT1	Adenylate cyclase 7	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00848	Grb	HUMAN|HGNC=4562|UniProtKB=Q13588	GRB2-related adapter protein	ISS	11971956	PubMed	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	MACMU|Ensembl=ENSMMUG00000004001|UniProtKB=F6XQZ0	Synaptotagmin-2	ISS	600104	OMIM	PTHR10024:SF223	SYNAPTOTAGMIN-2
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00049	Parkinson disease	P01230	Src kinase	BOVIN|Ensembl=ENSBTAG00000021424|UniProtKB=Q0VBZ0	Tyrosine-protein kinase CSK	ISS	11078745	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00057	Wnt signaling pathway	P01451	Galpha	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	IDA	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=3346|UniProtKB=P10688	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	12860966	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00004	Alzheimer disease-presenilin pathway	P00139	E-cadherin transmembrane fragment	PANTR|Ensembl=ENSPTRG00000008270|UniProtKB=H2QBE5	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF319	CADHERIN-1
P00024	Glycolysis	P00678	Enolase	YEAST|SGD=S000006202|UniProtKB=P0CX11	Enolase-related protein 2	ISS	6324969	gi	PTHR11902:SF1	ENOLASE
P00012	Cadherin signaling pathway	P00473	P120	PANTR|Ensembl=ENSPTRG00000016731|UniProtKB=H2QQN2	Uncharacterized protein	ISS			PTHR10372:SF9	CATENIN DELTA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	IDA	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00539	14-3-3	TAKRU|Ensembl=ENSTRUG00000004697|UniProtKB=H2SFG7	Uncharacterized protein	ISS	22165492	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00038	JAK/STAT signaling pathway	P01027	STAT	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	14984365	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	NEUCR|EnsemblGenome=EFNCRG00000006341|UniProtKB=P87253	Protein kinase C-like	IC	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00034	Integrin signalling pathway	P00932	FAK	MOUSE|MGI=MGI=104908|UniProtKB=Q9QVP9	Protein-tyrosine kinase 2-beta	IPI	10753828	PubMed	PTHR24418:SF94	PROTEIN-TYROSINE KINASE 2-BETA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DROME|FlyBase=FBgn0001123|UniProtKB=P20354	G protein alpha s subunit	IC	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00029	Huntington disease	P00788	Calpain	MOUSE|MGI=MGI=107437|UniProtKB=Q64691	Calpain-3	IDA	11675509	PubMed	PTHR10183:SF329	CALPAIN-3
P00021	FGF signaling pathway	P00638	PLCgamma	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00047	PDGF signaling pathway	P01148	Grb2	RAT|RGD=1306884|UniProtKB=Q4KM68	GRB2-related adaptor protein	ISS	51702266	gi	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00034	Integrin signalling pathway	P00951	Jnk	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00020	FAS signaling pathway	P00620	CytochromeC	CAEEL|WormBase=WBGene00000869|UniProtKB=Q18853	CYtochrome C	IGI	15163634	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00057	Wnt signaling pathway	P01428	Frizzled	MACMU|Ensembl=ENSMMUG00000006912|UniProtKB=F7EZ48	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF86	FRIZZLED-10
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	TAS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00059	p53 pathway	P04635	Sumo-1 ligase	HUMAN|HGNC=11125|UniProtKB=P61956	Small ubiquitin-related modifier 2	ISS			PTHR10562:SF11	SMALL UBIQUITIN-RELATED MODIFIER 2-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MOUSE|MGI=MGI=1309999|UniProtKB=Q922R0	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	PANTR|Ensembl=ENSPTRG00000005197|UniProtKB=A5A6J7	Ras-related protein Rap-1b	ISS	8576107	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00223	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	IXOSC|EnsemblGenome=ISCW009711|UniProtKB=B7Q3T6	THO complex subunit, putative	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	HUMAN|HGNC=289|UniProtKB=P25098	Beta-adrenergic receptor kinase 1	IDA	10852916	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	CAEBR|Gene=CBG10154|UniProtKB=A8XAI1	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P02752	Mannose metabolism	P03019	P-Mannose mutase	PANTR|Ensembl=ENSPTRG00000007748|UniProtKB=H2QAJ6	Phosphomannomutase	ISS	11042159	PubMed	PTHR10466:SF2	PHOSPHOMANNOMUTASE 2
P00025	Hedgehog signaling pathway	P00682	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01052	AC	PANTR|Ensembl=ENSPTRG00000001638|UniProtKB=H2Q0J3	Adenylate cyclase type 10	ISS	11744988	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00807	Actin	ORYSJ|EnsemblGenome=OS10G0510000|UniProtKB=A3C6D7	Actin-2	IDA	14684598	PubMed	PTHR11937:SF252	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04668	p53	HUMAN|HGNC=12003|UniProtKB=O15350	Tumor protein p73	TAS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00005	Angiogenesis	P00203	Erk	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00046	Oxidative stress response	P01132	c-jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	3136397	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00029	Huntington disease	P00774	Dynein complex	MACMU|Ensembl=ENSMMUG00000016974|UniProtKB=F7AZV1	Uncharacterized protein	ISS	9454836	PubMed	PTHR10676:SF358	DYNEIN HEAVY CHAIN 1, AXONEMAL
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	BOVIN|Ensembl=ENSBTAG00000012687|UniProtKB=F1MV64	Tyrosine-protein kinase receptor	ISS	14500580	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P00025	Hedgehog signaling pathway	P00682	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00645	Rac	MONDO|Ensembl=ENSMODG00000003244|UniProtKB=F6THF0	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00057	Wnt signaling pathway	P01435	SWI/SNF	HUMAN|HGNC=11109|UniProtKB=Q969G3	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1	IDA	11532957	PubMed	PTHR13711:SF206	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY E MEMBER 1
P00036	Interleukin signaling pathway	P00983	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	RAT|RGD=1307705|UniProtKB=B5DF62	Protein Pak4	ISS			PTHR24361:SF345	SERINE/THREONINE-PROTEIN KINASE PAK 4
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00030	Hypoxia response via HIF activation	P00814	P300	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04393	Ras Pathway	P04546	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00780	Microtubule	HUMAN|HGNC=30829|UniProtKB=Q9BVA1	Tubulin beta-2B chain	IDA	9454836	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00021	FGF signaling pathway	P00646	RasGAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	227170	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05918	p38 MAPK pathway	P06031	p38alpha	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02747	Histidine biosynthesis	P02990	Histidinol-phosphatase	BACSU|EnsemblGenome=BSU29620|UniProtKB=O34411	Histidinol-phosphatase	ISS			PTHR21039:SF0	HISTIDINOL-PHOSPHATASE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DROME|FlyBase=FBgn0011743|UniProtKB=P45891	Actin-like protein 53D	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01199	Galpha	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00030	Hypoxia response via HIF activation	P00819	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	CANAL|CGD=CAL0000189182|UniProtKB=P12461	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00011	Blood coagulation	P00422	FIXa	PANTR|Gene=F9|UniProtKB=Q95ND7	Coagulation factor IX	ISS	182609	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P00018	EGF receptor signaling pathway	P00539	14-3-3	DANRE|ZFIN=ZDB-GENE-061023-2|UniProtKB=E7F354	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P02785	Valine biosynthesis	P03216	Acetolactate synthase	ECOLI|EcoGene=EG10494|UniProtKB=P08142	Acetolactate synthase isozyme 1 large subunit	ISS			PTHR18968:SF128	ACETOLACTATE SYNTHASE ISOZYME 1 LARGE SUBUNIT
P00029	Huntington disease	P00790	beta-Tubulin	ORYSJ|EnsemblGenome=OS03G0661300|UniProtKB=Q76FS2	Tubulin beta-8 chain	TAS	9454836	PubMed	PTHR11588:SF246	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000020887|UniProtKB=F1MP22	Uncharacterized protein	ISS	14624853	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00009	Axon guidance mediated by netrin	P00357	Netrin	PANTR|Ensembl=ENSPTRG00000005315|UniProtKB=H2Q6M9	Uncharacterized protein	ISS	2538453	PubMed	PTHR10574:SF282	NETRIN-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00048	PI3 kinase pathway	P01189	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00010	B cell activation	P00391	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01319	PAK	MONDO|Ensembl=ENSMODG00000005255|UniProtKB=F7G800	Uncharacterized protein	ISS	11259591	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00011	Blood coagulation	P00439	Prekallikrein	MOUSE|MGI=MGI=102849|UniProtKB=P26262	Plasma kallikrein	ISS	6680584	gi	PTHR44459:SF2	PLASMA KALLIKREIN
P00021	FGF signaling pathway	P00627	ERK1-2	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01452	NFAT	CANLF|Ensembl=ENSCAFG00000011625|UniProtKB=F1PDD9	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04556	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	IDA	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	CHICK|Ensembl=ENSGALG00000005998|UniProtKB=Q5ZIW8	Uncharacterized protein	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P02728	Arginine biosynthesis	P02842	N-acetylornithine aminotransferase	PSEAE|EnsemblGenome=PA0895|UniProtKB=O30508	Succinylornithine transaminase/acetylornithine aminotransferase	ISS			PTHR11986:SF58	ALANINE--GLYOXYLATE AMINOTRANSFERASE 2, MITOCHONDRIAL
P00005	Angiogenesis	P00244	MAPKAPK2/3	MOUSE|MGI=MGI=2143163|UniProtKB=Q3UMW7	MAP kinase-activated protein kinase 3	ISS	11157753	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MOUSE|MGI=MGI=95778|UniProtKB=P20612	Guanine nucleotide-binding protein G(t) subunit alpha-1	ISS	6264430	PubMed	PTHR10218:SF67	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-1
P00024	Glycolysis	P00679	Aldolase	MOUSE|MGI=MGI=2447811|UniProtKB=A6ZI46	Fructose-bisphosphate aldolase	ISS	6086339	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	20908895	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05918	p38 MAPK pathway	P06023	MEF	MACMU|Ensembl=ENSMMUG00000018368|UniProtKB=F7H1J8	Uncharacterized protein	ISS			PTHR11945:SF335	MYOCYTE-SPECIFIC ENHANCER FACTOR 2B-RELATED
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	PANTR|Ensembl=ENSPTRG00000005528|UniProtKB=H2Q705	Nucleoside diphosphate kinase	ISS			PTHR11349:SF68	NUCLEOSIDE DIPHOSPHATE KINASE-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00047	PDGF signaling pathway	P01175	Shc	RAT|RGD=69348|UniProtKB=O70143	SHC-transforming protein 3	ISS	96404502	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P04393	Ras Pathway	P04541	p90RSK	MONDO|Ensembl=ENSMODG00000008086|UniProtKB=F6YJ34	Ribosomal protein S6 kinase	ISS	2779569	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00239	Eph	RAT|RGD=1309497|UniProtKB=B2B9A9	Ephrin B2	ISS	9990854	PubMed	PTHR11304:SF18	EPHRIN-B2
P04393	Ras Pathway	P04557	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02746	Heme biosynthesis	P02981	Glutamate-1-semialdehyde aminotransferase	BACSU|EnsemblGenome=BSU28120|UniProtKB=P30949	Glutamate-1-semialdehyde 2,1-aminomutase	ISS			PTHR43713:SF3	GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	HUMAN|HGNC=2091|UniProtKB=P09497	Clathrin light chain B	ISS	9388255	PubMed	PTHR10639:SF2	CLATHRIN LIGHT CHAIN B
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04393	Ras Pathway	P04556	Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	IDA	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00048	PI3 kinase pathway	P01192	p110	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00381	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02766	Phenylethylamine degradation	P03103	Phenylethylamine oxidase	ARATH|TAIR=AT4G12290|UniProtKB=Q8L742	Amine oxidase	ISS			PTHR10638:SF41	AMINE OXIDASE
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	YEAST|SGD=S000002898|UniProtKB=Q03407	Serine/threonine-protein kinase PKH1	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00053	T cell activation	P01303	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8051109	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BOVIN|Ensembl=ENSBTAG00000035697|UniProtKB=Q28024	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00013	Cell cycle	P00480	Proteasome	BRAFL|Gene=BRAFLDRAFT_283521|UniProtKB=C3XXY6	Putative uncharacterized protein	ISS	9727008	PubMed	PTHR10410:SF5	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 14
P00017	DNA replication	P00527	Histones	MACMU|Ensembl=ENSMMUG00000001441|UniProtKB=F7BRX2	Histone H3	ISS	20448842	PubMed	PTHR11426:SF183	HISTONE H3.1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	1764995	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00013	Cell cycle	P00480	Proteasome	PANTR|Ensembl=ENSPTRG00000022722|UniProtKB=H2R079	Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 12	ISS	12477932	PubMed	PTHR10855:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00642	MEK1-2	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00045	Notch signaling pathway	P01103	Next	MACMU|Ensembl=ENSMMUG00000017022|UniProtKB=F7HQZ9	Uncharacterized protein	ISS	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00046	Oxidative stress response	P01135	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00005	Angiogenesis	P00223	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00310	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	IDA	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	DANRE|ZFIN=ZDB-GENE-070112-342|UniProtKB=A1L271	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	PANTR|Ensembl=ENSPTRG00000023608|UniProtKB=H2QZZ2	Uncharacterized protein	ISS	11554549	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00037	Ionotropic glutamate receptor pathway	P01006	NR2C	RAT|RGD=2739|UniProtKB=Q00961	Glutamate receptor ionotropic, NMDA 2C	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	BOVIN|Ensembl=ENSBTAG00000013412|UniProtKB=F1MAZ9	Uncharacterized protein	ISS			PTHR12533:SF10	NUCLEAR FACTOR OF ACTIVATED T-CELLS 5
P00030	Hypoxia response via HIF activation	P00819	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00632	Akt	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	IGI	12089061	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00383	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346347|UniProtKB=Q9WVS8	Mitogen-activated protein kinase 7	ISS	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00034	Integrin signalling pathway	P00951	Jnk	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00059	p53 pathway	P04633	P110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	IC	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00005	Angiogenesis	P00231	HSP27	MONDO|Ensembl=ENSMODG00000014448|UniProtKB=F7ATU3	Uncharacterized protein	ISS			PTHR11527:SF163	HEAT SHOCK PROTEIN BETA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MONDO|Ensembl=ENSMODG00000012331|UniProtKB=F7E2P1	Phosphoinositide phospholipase C	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MOUSE|MGI=MGI=1915339|UniProtKB=P59999	Actin-related protein 2/3 complex subunit 4	ISS	9230079	PubMed	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	STRPU|EnsemblGenome=SPU_012329|UniProtKB=W4Y9B6	Uncharacterized protein	IC			PTHR19957:SF41	SYNTAXIN-1A
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ORYSJ|EnsemblGenome=OS06G0607800|UniProtKB=Q69Q32	Os06g0607800 protein	ISS			PTHR23073:SF59	SUBFAMILY NOT NAMED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	RCA	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00029	Huntington disease	P00807	Actin	RAT|RGD=2027|UniProtKB=P63269	Actin, gamma-enteric smooth muscle	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00020	FAS signaling pathway	P00615	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00051	TCA cycle	P01270	Malate Dehydrogenase	METJA|EnsemblGenome=MJ_1425|UniProtKB=Q58820	L-sulfolactate dehydrogenase	IDA	20309698	PubMed	PTHR11091:SF0	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04542	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DANRE|ZFIN=ZDB-GENE-040718-134|UniProtKB=Q6DH55	Guanine nucleotide binding protein (G protein), beta polypeptide 3, like	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00012	Cadherin signaling pathway	P00467	alpha-catenin	HUMAN|HGNC=2509|UniProtKB=P35221	Catenin alpha-1	ISS	1904011	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00048	PI3 kinase pathway	P01179	PKB	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	TAS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	IC	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04398	p53 pathway feedback loops 2	P04657	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01153	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00021	FGF signaling pathway	P00629	PP2A	RAT|RGD=3381|UniProtKB=P62716	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	DROME|FlyBase=FBgn0039747|UniProtKB=Q9VAA2	Adenosine receptor, isoform A	IDA	12106606	PubMed	PTHR24246:SF27	ADENOSINE RECEPTOR A2A
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	HUMAN|HGNC=15781|UniProtKB=Q494W8	CHRNA7-FAM7A fusion protein	IC			PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	TAS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00021	FGF signaling pathway	P00638	PLCgamma	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00049	Parkinson disease	P01236	Casein kinase II	PHYPA|Gene=PHYPADRAFT_183198|UniProtKB=A9SBU0	Predicted protein	ISS	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04585	TRH	RAT|RGD=620436|UniProtKB=P11962	Glycoprotein hormones alpha chain	ISS			PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P00059	p53 pathway	P01485	p53	BOVIN|Ensembl=ENSBTAG00000001069|UniProtKB=P67939	Cellular tumor antigen p53	TAS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00021	FGF signaling pathway	P00629	PP2A	BOVIN|Gene=PPP2R1A|UniProtKB=Q32PI5	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform	ISS	11994459	PubMed	PTHR10648:SF2	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 65 KDA REGULATORY SUBUNIT A ALPHA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MOUSE|MGI=MGI=107191|UniProtKB=P36898	Bone morphogenetic protein receptor type-1B	TAS	9395284	PubMed	PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P00052	TGF-beta signaling pathway	P01286	TGFbeta	STRPU|EnsemblGenome=SPU_000669|UniProtKB=W4XBC2	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF234	PROTEIN DECAPENTAPLEGIC
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ORYSJ|EnsemblGenome=OS02G0148100|UniProtKB=Q6Z437	Mitogen-activated protein kinase 3	ISS	11707292	PubMed	PTHR24055:SF216	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	DICDI|dictyBase=DDB_G0283907|UniProtKB=P34099	cAMP-dependent protein kinase catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00018	EGF receptor signaling pathway	P00539	14-3-3	DICDI|dictyBase=DDB_G0269138|UniProtKB=P54632	14-3-3-like protein	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00059	p53 pathway	P04609	PI3K	CAEEL|WormBase=WBGene00006932|UniProtKB=Q9TXI7	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01438	PP2A	DANRE|ZFIN=ZDB-GENE-030904-7|UniProtKB=Q8AXX6	Ppp2r5e2 protein	ISS	8703017	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	BRAFL|Gene=BRAFLDRAFT_220697|UniProtKB=C3ZSF0	Putative uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00047	PDGF signaling pathway	P01159	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008018|UniProtKB=F7EPG4	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	CANLF|Gene=HTR2C|UniProtKB=Q60F97	5-hydroxytryptamine receptor 2C	ISS			PTHR24247:SF32	5-HYDROXYTRYPTAMINE RECEPTOR 2C
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MONDO|Ensembl=ENSMODG00000004799|UniProtKB=F6VM87	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00547	PP2A	CHICK|Ensembl=ENSGALG00000010273|UniProtKB=P48463	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	IGI	2461222	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00021	FGF signaling pathway	P00641	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00034	Integrin signalling pathway	P00910	Grb2	BOVIN|Ensembl=ENSBTAG00000003707|UniProtKB=A6QLK6	GRB2-related adapter protein	ISS	8647802	PubMed	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00021	FGF signaling pathway	P00624	14-3-3	CANLF|Ensembl=ENSCAFG00000013549|UniProtKB=E2QVP6	Uncharacterized protein	ISS	22165492	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00048	PI3 kinase pathway	P01198	FOXO	RAT|RGD=1309196|UniProtKB=D3ZBQ1	Forkhead box O3a (Predicted)	ISS	12048180	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01093	AChE	CAEBR|Gene=CBG14965|UniProtKB=A8XL40	Carboxylic ester hydrolase	ISS	86008285	PubMed	PTHR43918:SF6	CARBOXYLIC ESTER HYDROLASE
P00015	Circadian clock system	G01501	cry	BOVIN|Ensembl=ENSBTAG00000010149|UniProtKB=F1MXB2	Uncharacterized protein	ISS	10428031	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	PANTR|Ensembl=ENSPTRG00000006218|UniProtKB=H2Q834	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00021	FGF signaling pathway	P00632	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00627	ERK1-2	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	NAS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CAEBR|Gene=CBG05858|UniProtKB=A8X1H0	Protein CBR-EGL-19 (Fragment)	ISS	15621031	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00006	Apoptosis signaling pathway	P00260	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	G04689	Cyclin G	CANLF|Ensembl=ENSCAFG00000017207|UniProtKB=E2RSX2	Uncharacterized protein	ISS	7957050	PubMed	PTHR10177:SF59	CYCLIN-G1
P05913	Enkephalin release	P05975	GPCR (s)	MONDO|Ensembl=ENSMODG00000008382|UniProtKB=F7CDR6	Uncharacterized protein (Fragment)	ISS	12093103	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00057	Wnt signaling pathway	P01465	Ggamma	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IDA	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	XENTR|Xenbase=XB-GENE-969601|UniProtKB=Q28H40	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P02738	De novo purine biosynthesis	P02899	GMP synthase	PSEAE|EnsemblGenome=PA3769|UniProtKB=Q9HXM6	GMP synthase [glutamine-hydrolyzing]	ISS			PTHR11922:SF2	GMP SYNTHASE  GLUTAMINE-HYDROLYZING
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	CHICK|Gene=FZD1|UniProtKB=O57328	Frizzled-1	TAS	8717036	PubMed	PTHR11309:SF81	FRIZZLED-1
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000001962|UniProtKB=F6V2H6	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00044	Nicotinic acetylcholine receptor signaling pathway	P01098	CHT1	MACMU|Ensembl=ENSMMUG00000001686|UniProtKB=F7G314	Uncharacterized protein	ISS			PTHR12385:SF13	CHOLINE TRANSPORTER-LIKE PROTEIN 3
P00029	Huntington disease	P00807	Actin	CAEBR|Gene=CBG23091|UniProtKB=A8Y4Q9	Protein CBR-ACT-2	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	LEPIN|EnsemblGenome=LA_1929|UniProtKB=Q8CXT1	CAP family transcription factor	IC	2372396	PubMed	PTHR45452:SF1	SUBFAMILY NOT NAMED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04393	Ras Pathway	P04556	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00001	Adrenaline and noradrenaline biosynthesis	P00065	DAT	HUMAN|HGNC=11049|UniProtKB=Q01959	Sodium-dependent dopamine transporter	ISS	92107910	PubMed	PTHR11616:SF38	SODIUM-DEPENDENT DOPAMINE TRANSPORTER
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	ANOGA|EnsemblGenome=AGAP001394|UniProtKB=F5HMS4	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00006	Apoptosis signaling pathway	P00321	HSP70	XENTR|Xenbase=XB-GENE-480060|UniProtKB=F6UZ27	Uncharacterized protein	ISS	10934466	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00048	PI3 kinase pathway	P01199	Galpha	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	IC	8457205	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00018	EGF receptor signaling pathway	P00551	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01179	PKB	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00780	Microtubule	PRIPA|Gene=PPA21756|UniProtKB=H3FHK9	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF255	TUBA7L PROTEIN
P00018	EGF receptor signaling pathway	P00543	ERK1-2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05730	Endogenous cannabinoid signaling	P05746	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	IC	91298951	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00034	Integrin signalling pathway	P00944	Actin	CANLF|Ensembl=ENSCAFG00000016020|UniProtKB=O18840	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00029	Huntington disease	P00775	Rac	DICPU|Gene=DICPUDRAFT_55703|UniProtKB=F0ZN94	Putative uncharacterized protein racC	ISS			PTHR24072:SF117	RHO-RELATED PROTEIN RACC
P00018	EGF receptor signaling pathway	P00547	PP2A	TAKRU|Ensembl=ENSTRUG00000008018|UniProtKB=H2T5N4	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01322	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00274	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00005	Angiogenesis	P00227	PLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00021	FGF signaling pathway	P00628	JNK1-3	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00030	Hypoxia response via HIF activation	P00816	VHL	RAT|RGD=3960|UniProtKB=Q64259	Von Hippel-Lindau disease tumor suppressor	TAS	14526383	PubMed	PTHR15160:SF1	VON HIPPEL-LINDAU DISEASE TUMOR SUPPRESSOR-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05913	Enkephalin release	P05972	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	BOVIN|Gene=ACVR1|UniProtKB=Q28041	Activin receptor type-1	TAS	9395284	PubMed	PTHR23255:SF69	ACTIVIN RECEPTOR TYPE-1
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01471	alpha-catenin	MOUSE|MGI=MGI=1859649|UniProtKB=O88327	Alpha-catulin	IDA	9362521	PubMed	PTHR18914:SF8	ALPHA-CATULIN
P00006	Apoptosis signaling pathway	P00297	NFkappaB	BOVIN|Ensembl=ENSBTAG00000006017|UniProtKB=F6Q9X9	Uncharacterized protein	ISS	12574369	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00313	IKK	HUMAN|HGNC=5960|UniProtKB=O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MACMU|Ensembl=ENSMMUG00000020134|UniProtKB=F6U055	Uncharacterized protein	ISS	11266476	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00013	Cell cycle	P00483	Cyclin E	MACMU|Ensembl=ENSMMUG00000020668|UniProtKB=F7BEI4	Uncharacterized protein	ISS	12628165	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	RAT|RGD=1304556|UniProtKB=P63259	Actin, cytoplasmic 2	ISS	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00047	PDGF signaling pathway	P01164	PDK1/2	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	9094314	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	ECOLI|EcoGene=EG10390|UniProtKB=P00962	Glutamine--tRNA ligase	ISS			PTHR43097:SF5	GLUTAMATE--TRNA LIGASE, CYTOPLASMIC
P00029	Huntington disease	P00790	beta-Tubulin	IXOSC|EnsemblGenome=ISCW021482|UniProtKB=B7Q717	Beta-tubulin, putative (Fragment)	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00629	PP2A	MOUSE|MGI=MGI=2388481|UniProtKB=Q91V89	Protein Ppp2r5d	ISS	96161994	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00049	Parkinson disease	P01208	Hsp70	DROME|FlyBase=FBgn0001217|UniProtKB=P11146	Heat shock 70 kDa protein cognate 2	IDA	12150907	PubMed	PTHR19375:SF256	HSP70 PROTEIN-RELATED
P05913	Enkephalin release	P05978	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	YEAST|SGD=S000001283|UniProtKB=P16370	DNA-directed RNA polymerase II subunit RPB3	ISS	2187864	PubMed	PTHR11800:SF2	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3
P05913	Enkephalin release	P05974	G-Protein (i)	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00040	Metabotropic glutamate receptor group II pathway	P01052	AC	PANTR|Ensembl=ENSPTRG00000001638|UniProtKB=H2Q0J3	Adenylate cyclase type 10	ISS	10915626	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	BOVIN|Ensembl=ENSBTAG00000035084|UniProtKB=F1MLG5	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF22	FRIZZLED-3
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00005	Angiogenesis	P00204	PLD	MOUSE|MGI=MGI=892877|UniProtKB=P97813	Phospholipase D2	ISS	9538008	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	CANLF|Ensembl=ENSCAFG00000000132|UniProtKB=J9P309	Actin-related protein 2/3 complex subunit 3	ISS	12473693	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00036	Interleukin signaling pathway	P00970	Interleukin	BOVIN|Ensembl=ENSBTAG00000010349|UniProtKB=P08831	Interleukin-1 alpha	ISS	1292627	PubMed	PTHR45409:SF1	INTERLEUKIN-1 ALPHA
P00005	Angiogenesis	P00223	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00920	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	CANLF|Ensembl=ENSCAFG00000025220|UniProtKB=E2R174	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF66	SERINE/THREONINE-PROTEIN KINASE RECEPTOR R3
P00018	EGF receptor signaling pathway	P00557	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00718	Phosphorylase a	HUMAN|HGNC=9723|UniProtKB=P11216	Glycogen phosphorylase, brain form	IDA	4318782	PubMed	PTHR11468:SF1	GLYCOGEN PHOSPHORYLASE, BRAIN FORM
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00005	Angiogenesis	P00249	PAK	XENTR|Xenbase=XB-GENE-961764|UniProtKB=F6W3Y0	Uncharacterized protein	ISS	11259591	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	RCA	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00029	Huntington disease	P00786	ARF	MONDO|Ensembl=ENSMODG00000003056|UniProtKB=F6PNX7	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	ISS	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P05915	Opioid proenkephalin pathway	P05994	G-protein	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00023	General transcription regulation	P00668	TFIIB	YEAST|SGD=S000003478|UniProtKB=P29056	Transcription factor IIIB 70 kDa subunit	ISS			PTHR11618:SF4	TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00036	Interleukin signaling pathway	P00990	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00121	CD44 intracellular fragment	PANTR|Ensembl=ENSPTRG00000003501|UniProtKB=H2Q3E8	Uncharacterized protein	ISS	14871815	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P00053	T cell activation	P01307	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00021	FGF signaling pathway	P00641	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CANLF|Gene=DRD2|UniProtKB=Q9GJU1	D(2) dopamine receptor	IDA	2137198	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00034	Integrin signalling pathway	P00909	ASAP1	MOUSE|MGI=MGI=2183559|UniProtKB=Q9EPJ9	ADP-ribosylation factor GTPase-activating protein 1	IPI			PTHR23180:SF35	ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1
P00057	Wnt signaling pathway	P01440	Cadherin	DROME|FlyBase=FBgn0015609|UniProtKB=O15943	Neural-cadherin	IDA	8120095	PubMed	PTHR43956:SF4	NEURAL-CADHERIN
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	MONDO|Ensembl=ENSMODG00000002420|UniProtKB=F7EGU4	Uncharacterized protein (Fragment)	ISS			PTHR10943:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2
P00018	EGF receptor signaling pathway	P00562	p38	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	IGI	10995439	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00012	Cadherin signaling pathway	P00474	Wnt	MACMU|Ensembl=ENSMMUG00000017346|UniProtKB=F7H9B8	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P00034	Integrin signalling pathway	P00931	Integrin beta	CANLF|Ensembl=ENSCAFG00000013735|UniProtKB=F1PPG5	Integrin beta	IDA	4206165	gi	PTHR10082:SF25	INTEGRIN BETA-3
P05730	Endogenous cannabinoid signaling	P05751	Galpha	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	CAEEL|WormBase=WBGene00004769|UniProtKB=P52166	Presenilin sel-12	TAS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00057	Wnt signaling pathway	P01465	Ggamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000018059|UniProtKB=C7G3M9	Glutamate receptor, metabotropic 4	ISS	9407094	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	LEIMA|EnsemblGenome=LmjF.35.3960|UniProtKB=E9AFM1	Protein kinase A catalytic subunit isoform 2	ISS	10553940	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=69424|UniProtKB=Q99P84	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	10934033	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	NEUCR|EnsemblGenome=EFNCRG00000008291|UniProtKB=Q7SAL1	UDP-glucose 4-epimerase Gal10	ISS	606023	OMIM	PTHR10917:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3
P00034	Integrin signalling pathway	P00923	Arf1	MACMU|Ensembl=ENSMMUG00000021421|UniProtKB=F7EF01	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF234	ADP-RIBOSYLATION FACTOR 1
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	CAEBR|Gene=CBG12628|UniProtKB=A8XG70	Protein CBR-SNT-4	ISS			PTHR10024:SF218	FI18813P1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00021	FGF signaling pathway	P00629	PP2A	HUMAN|HGNC=9312|UniProtKB=Q14738	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	IPI	10092233	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	IDA	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02748	Isoleucine biosynthesis	P02994	Branched chain amino acid aminotransferase	CAEBR|Gene=CBG00050|UniProtKB=A8WM75	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF44	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P00060	Ubiquitin proteasome pathway	P01491	E2	PHANO|EnsemblGenome=SNOG_06548|UniProtKB=Q0UNW6	Uncharacterized protein	ISS			PTHR43898:SF1	UBIQUITIN-CONJUGATING ENZYME E2-17 KDA
P00021	FGF signaling pathway	P00627	ERK1-2	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00009	Axon guidance mediated by netrin	P00363	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT1G73670|UniProtKB=Q9C9U4	Mitogen-activated protein kinase 15	ISS	12324206	gi	PTHR24055:SF246	MITOGEN-ACTIVATED PROTEIN KINASE 15-RELATED
P00053	T cell activation	P01312	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	MACMU|Ensembl=ENSMMUG00000017143|UniProtKB=F7H113	Uncharacterized protein	ISS	11907044	PubMed	PTHR44025:SF5	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00036	Interleukin signaling pathway	P00967	c-fos	MACMU|Ensembl=ENSMMUG00000010574|UniProtKB=A5A6H2	C-fos	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	HUMAN|HGNC=4593|UniProtKB=Q13255	Metabotropic glutamate receptor 1	IDA	9407094	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00004	Alzheimer disease-presenilin pathway	P00144	Ire-1	MACMU|Ensembl=ENSMMUG00000015185|UniProtKB=F6WBI3	Uncharacterized protein	ISS	10619423	PubMed	PTHR13954:SF17	SERINE/THREONINE-PROTEIN KINASE/ENDORIBONUCLEASE IRE1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	DICDI|dictyBase=DDB_G0277143|UniProtKB=P36408	Guanine nucleotide-binding protein subunit beta	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	TAS	14526383	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01297	MEKK	RAT|RGD=620966|UniProtKB=Q62925	Mitogen-activated protein kinase kinase kinase 1	RCA	12049732	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00049	Parkinson disease	P01208	Hsp70	MOUSE|MGI=MGI=95835|UniProtKB=P20029	78 kDa glucose-regulated protein	IDA	10934466	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00053	T cell activation	P01307	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00056	VEGF signaling pathway	P01415	MAPKAPK2/3	DROME|FlyBase=FBgn0013987|UniProtKB=P49071	MAP kinase-activated protein kinase 2	ISS			PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00249	PAK	MOUSE|MGI=MGI=1339984|UniProtKB=Q8CIN4	Serine/threonine-protein kinase PAK 2	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00852	PYK2	MOUSE|MGI=MGI=104908|UniProtKB=Q9QVP9	Protein-tyrosine kinase 2-beta	IDA	10753828	PubMed	PTHR24418:SF94	PROTEIN-TYROSINE KINASE 2-BETA
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P06209	ALP23B signaling pathway	P06225	ALP23B full length	DROME|FlyBase=FBgn0031461|UniProtKB=Q9VQG9	Dawdle, isoform A	IEA	12537572	PubMed	PTHR11848:SF226	DAWDLE, ISOFORM A
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	MOUSE|MGI=MGI=88296|UniProtKB=O55017	Voltage-dependent N-type calcium channel subunit alpha-1B	IDA	11976940	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P02742	Tetrahydrofolate biosynthesis	P02945	Dihydropteroate synthase	METAC|EnsemblGenome=MA_3516|UniProtKB=Q8TK98	Dihydropteroate synthase	ISS			PTHR20941:SF1	FOLIC ACID SYNTHESIS PROTEIN FOL1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00047	PDGF signaling pathway	P01174	Rho	MOUSE|MGI=MGI=1918794|UniProtKB=B2RQE8	Rho GTPase-activating protein 42	ISS			PTHR12552:SF3	RHO GTPASE-ACTIVATING PROTEIN 42
P05913	Enkephalin release	P05972	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00947	Laminin	BOVIN|Ensembl=ENSBTAG00000011412|UniProtKB=F1MNT4	Uncharacterized protein	ISS	2538453	PubMed	PTHR10574:SF233	LAMININ SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00556	PLCgamma	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00012	Cadherin signaling pathway	P00470	F-actin	CAEBR|Gene=CBG02167|UniProtKB=A8WS37	Protein CBG02167	ISS	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	MOUSE|MGI=MGI=1861622|UniProtKB=Q9JLJ2	4-trimethylaminobutyraldehyde dehydrogenase	IC			PTHR11699:SF228	4-TRIMETHYLAMINOBUTYRALDEHYDE DEHYDROGENASE
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04393	Ras Pathway	P04542	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	MACMU|Ensembl=ENSMMUG00000021927|UniProtKB=F6T4B4	Uncharacterized protein	ISS	10209034	PubMed	PTHR23220:SF69	INTEGRIN ALPHA-9
P00018	EGF receptor signaling pathway	P00561	STAT	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P02778	Sulfate assimilation	P03167	Sulfate adenylyltransferase	DROME|FlyBase=FBgn0020389|UniProtKB=Q8IQV1	PAPS synthetase, isoform D	ISS			PTHR11055:SF1	PAPS SYNTHETASE, ISOFORM D
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	MACMU|Ensembl=ENSMMUG00000004001|UniProtKB=F6XQZ0	Synaptotagmin-2	ISS	SYT2_MOUSE	SPACC	PTHR10024:SF223	SYNAPTOTAGMIN-2
P05912	Dopamine receptor mediated signaling pathway	P05970	TH	HUMAN|HGNC=11782|UniProtKB=P07101	Tyrosine 3-monooxygenase	ISS	12814656	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00021	FGF signaling pathway	P00627	ERK1-2	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MACMU|Ensembl=ENSMMUG00000015705|UniProtKB=F6SM00	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00011	Blood coagulation	P00460	FXI	PANTR|Gene=F9|UniProtKB=Q95ND7	Coagulation factor IX	ISS	182609	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P05913	Enkephalin release	P05977	G-Protein (s)	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00057	Wnt signaling pathway	P01444	Wnt	XENTR|Xenbase=XB-GENE-485280|UniProtKB=F6X3B2	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00021	FGF signaling pathway	P00648	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00010	B cell activation	P00381	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00359	NFAT	HUMAN|HGNC=7777|UniProtKB=Q12968	Nuclear factor of activated T-cells, cytoplasmic 3	IDA	9462517	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00005	Angiogenesis	P00187	beta catenin	ORNAN|Ensembl=ENSOANG00000006811|UniProtKB=F6WBD5	Uncharacterized protein	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00627	ERK1-2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	RAT|RGD=1586637|UniProtKB=F1LMY4	Ryanodine receptor 1	ISS	15226293	PubMed	PTHR13715:SF15	RYANODINE RECEPTOR 1
P00045	Notch signaling pathway	P01105	TACE	ORNAN|Ensembl=ENSOANG00000009151|UniProtKB=F7EK00	Uncharacterized protein	ISS			PTHR11905:SF4	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 10
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	IDA	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DROME|FlyBase=FBgn0000042|UniProtKB=P10987	Actin-5C	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00060	Ubiquitin proteasome pathway	P01491	E2	MOUSE|MGI=MGI=1914378|UniProtKB=P62254	Ubiquitin-conjugating enzyme E2 G1	ISS			PTHR24067:SF3	UBIQUITIN-CONJUGATING ENZYME E2 G1
P00053	T cell activation	P01295	vav	BOVIN|Ensembl=ENSBTAG00000031575|UniProtKB=E1BBD2	Uncharacterized protein	ISS	14623913	PubMed	PTHR22826:SF97	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3
P00011	Blood coagulation	P00458	GP IIIa	MACMU|Ensembl=ENSMMUG00000003289|UniProtKB=F7FG54	Integrin beta	ISS	7949057	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CAEBR|Gene=CBG02161|UniProtKB=A8WS32	Protein CBG02161	ISS	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00059	p53 pathway	P01480	PTEN	XENTR|Xenbase=XB-GENE-491433|UniProtKB=B1H2U0	Pten protein	ISS	10555148	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	MONDO|Ensembl=ENSMODG00000012900|UniProtKB=F7GDG7	Uncharacterized protein	ISS	10487978	PubMed	PTHR10749:SF8	PHOSPHORYLASE B KINASE REGULATORY SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	BOVIN|Ensembl=ENSBTAG00000009065|UniProtKB=F1MXH6	Uncharacterized protein	ISS	11730323	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	CAEBR|Gene=CBG07560|UniProtKB=A8X4K1	Protein CBG07560	ISS			PTHR24057:SF20	SUBFAMILY NOT NAMED
P00059	p53 pathway	P04609	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P02738	De novo purine biosynthesis	P02909	GDP reductase	PLAF7|EnsemblGenome=PF14_0352|UniProtKB=Q8IL94	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00018	EGF receptor signaling pathway	P00562	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00015	Circadian clock system	P00502	Casein kinase I	MOUSE|MGI=MGI=1351660|UniProtKB=Q9JMK2	Casein kinase I isoform epsilon	IDA	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00030	Hypoxia response via HIF activation	P00820	HIF-1beta	CANLF|Ensembl=ENSCAFG00000012149|UniProtKB=J9P204	Uncharacterized protein	ISS	7836384	PubMed	PTHR23042:SF50	ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00034	Integrin signalling pathway	P00932	FAK	HUMAN|HGNC=9611|UniProtKB=Q05397	Focal adhesion kinase 1	IPI	12640026	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	XENTR|Xenbase=XB-GENE-478789|UniProtKB=F6QE63	Uncharacterized protein	ISS	12356903	PubMed	PTHR11267:SF83	BRACHYURY PROTEIN
P00005	Angiogenesis	P00210	eNOS	MOUSE|MGI=MGI=97362|UniProtKB=P70313	Nitric oxide synthase, endothelial	ISS	9837777	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00057	Wnt signaling pathway	P01452	NFAT	PANTR|Ensembl=ENSPTRG00000006218|UniProtKB=H2Q834	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00839	SHIP	BOVIN|Ensembl=ENSBTAG00000019167|UniProtKB=E1BBJ7	Uncharacterized protein	ISS	12145149	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00845	Cyclooxygenase	RAT|RGD=620349|UniProtKB=P35355	Prostaglandin G/H synthase 2	ISS	12163371	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00021	FGF signaling pathway	P00642	MEK1-2	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	MOUSE|MGI=MGI=1913741|UniProtKB=P62876	DNA-directed RNA polymerases I, II, and III subunit RPABC5	ISS			PTHR23431:SF3	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00029	Huntington disease	P00782	alpha-Adaptin	DROME|FlyBase=FBgn0264855|UniProtKB=P91926	AP-2 complex subunit alpha	IDA	11532990	PubMed	PTHR22780:SF4	AP-2 COMPLEX SUBUNIT ALPHA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=97438|UniProtKB=P32300	Delta-type opioid receptor	IDA	12093103	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00019	Endothelin signaling pathway	P00589	Akt	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	IGI	12655147	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P02748	Isoleucine biosynthesis	P02994	Branched chain amino acid aminotransferase	MACMU|Ensembl=ENSMMUG00000010079|UniProtKB=F6ZG15	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF39	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, MITOCHONDRIAL
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00018	EGF receptor signaling pathway	P00552	Ras	BOVIN|Ensembl=ENSBTAG00000011905|UniProtKB=A5PKL2	RRAS2 protein	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00056	VEGF signaling pathway	P01411	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00005	Angiogenesis	P00188	Ets	MONDO|Ensembl=ENSMODG00000004730|UniProtKB=F6Y1Z2	Uncharacterized protein	ISS	3060801	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00047	PDGF signaling pathway	P01157	MAPKAPK2	HUMAN|HGNC=6887|UniProtKB=P49137	MAP kinase-activated protein kinase 2	ISS	7923354	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	PANTR|Ensembl=ENSPTRG00000005528|UniProtKB=H2Q705	Nucleoside diphosphate kinase	ISS			PTHR11349:SF68	NUCLEOSIDE DIPHOSPHATE KINASE-RELATED
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05943	GRK2	MACMU|Ensembl=ENSMMUG00000015925|UniProtKB=F7AL30	Protein-serine/threonine kinase	ISS	10852916	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	HUMAN|HGNC=16647|UniProtKB=O00574	C-X-C chemokine receptor type 6	IDA	11238560	PubMed	PTHR10489:SF705	C-X-C CHEMOKINE RECEPTOR TYPE 6
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00047	PDGF signaling pathway	P01161	Raf	XENTR|Xenbase=XB-GENE-1014202|UniProtKB=F6V946	Uncharacterized protein (Fragment)	ISS	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00006	Apoptosis signaling pathway	P00260	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P02756	N-acetylglucosamine metabolism	P03041	Glucosamine-6-phosphate deaminase	GIAIC|EnsemblGenome=GL50803_10829|UniProtKB=E2RTN3	Glucosamine-6-phosphate isomerase	ISS			PTHR11280:SF5	GLUCOSAMINE-6-PHOSPHATE ISOMERASE
P06587	Nicotine pharmacodynamics pathway	P06592	CHRNA6	PANTR|Ensembl=ENSPTRG00000020210|UniProtKB=Q5IS76	Neuronal acetylcholine receptor subunit alpha-6	ISS	85270494	PubMed	PTHR18945:SF82	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-6
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	ORNAN|Ensembl=ENSOANG00000013961|UniProtKB=F6VPY1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00049	Parkinson disease	P01208	Hsp70	DANRE|ZFIN=ZDB-GENE-110713-1|UniProtKB=Q6PH56	Hsp70 protein	IDA	12150907	PubMed	PTHR19375:SF256	HSP70 PROTEIN-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	CAEBR|Gene=CBG23090|UniProtKB=A8Y4R0	Protein CBG23090	ISS	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00048	PI3 kinase pathway	P01179	PKB	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00021	FGF signaling pathway	P00636	FGFR1-4	HUMAN|HGNC=3688|UniProtKB=P11362	Fibroblast growth factor receptor 1	IGI	12799194	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P04398	p53 pathway feedback loops 2	G04714	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00036	Interleukin signaling pathway	P00965	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IC	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g210933|UniProtKB=A7SEA7	Predicted protein	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02781	Threonine biosynthesis	P03188	Homoserine dehydrogenase	AQUAE|EnsemblGenome=aq_1812|UniProtKB=O67677	Homoserine dehydrogenase	ISS			PTHR43331:SF1	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01143	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04566	Stat 1/3	MONDO|Ensembl=ENSMODG00000028212|UniProtKB=F7BYN4	Signal transducer and activator of transcription	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00010	B cell activation	P00381	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	MOUSE|MGI=MGI=1277956|UniProtKB=Q922Q4	Pyrroline-5-carboxylate reductase 2	ISS			PTHR11645:SF4	PYRROLINE-5-CARBOXYLATE REDUCTASE 2
P02738	De novo purine biosynthesis	P02891	GDP kinase	NEUCR|EnsemblGenome=EFNCRG00000003892|UniProtKB=Q9UUY8	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00005	Angiogenesis	P00203	Erk	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	88234494	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	14526383	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MOUSE|MGI=MGI=95816|UniProtKB=B1AS29	Glutamate receptor ionotropic, kainate 3	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00057	Wnt signaling pathway	P01444	Wnt	DROME|FlyBase=FBgn0038134|UniProtKB=Q9VFX1	Wnt inhibitor of Dorsal protein	ISS	8717036	PubMed	PTHR12027:SF98	PROTEIN WNT-RELATED
P06664	Gonadotropin-releasing hormone receptor pathway	P06832	c-Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	RCA	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00644	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00010	B cell activation	P00384	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04393	Ras Pathway	P04567	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05754	Ggamma	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	RCA	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P05913	Enkephalin release	P05976	Enkephalin	BOVIN|Ensembl=ENSBTAG00000004924|UniProtKB=P01211	Proenkephalin-A	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00547	PP2A	HUMAN|HGNC=9299|UniProtKB=P67775	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	NAS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=107924|UniProtKB=Q64527	Protein Wnt-8a	IDA	8717036	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00048	PI3 kinase pathway	P01206	14-3-3	CHICK|Ensembl=ENSGALG00000010725|UniProtKB=Q5ZKC9	14-3-3 protein zeta	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05913	Enkephalin release	P05977	G-Protein (s)	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00047	PDGF signaling pathway	P01167	Ets	RAT|RGD=628860|UniProtKB=O70132	Protein FEV	ISS	15298723	PubMed	PTHR11849:SF203	PROTEIN FEV
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEEL|WormBase=WBGene00018620|UniProtKB=O44588	Uncharacterized protein	ISS	3755548	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P00034	Integrin signalling pathway	P00922	Collagen	RAT|RGD=1305182|UniProtKB=D4ADG9	Protein Col8a2	ISS	10778855	PubMed	PTHR44057:SF3	COLLAGEN ALPHA-2 VIII  CHAIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	TAS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00036	Interleukin signaling pathway	P00987	SRF	MONDO|Ensembl=ENSMODG00000018981|UniProtKB=F7FP88	Uncharacterized protein	ISS	8660892	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	IDA	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	12657601	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05918	p38 MAPK pathway	P05921	MKP5	CANLF|Ensembl=ENSCAFG00000013641|UniProtKB=E2R7G4	Uncharacterized protein	ISS	10597297	PubMed	PTHR10159:SF299	DUAL SPECIFICITY PROTEIN PHOSPHATASE 10
P02749	Leucine biosynthesis	P03002	Isopropylmalate isomerase	SULSO|EnsemblGenome=SSO2471|UniProtKB=Q97VY2	3-isopropylmalate dehydratase large subunit	ISS			PTHR43822:SF4	SUBFAMILY NOT NAMED
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04397	p53 pathway by glucose deprivation	P04639	AMPK	PANTR|Ensembl=ENSPTRG00000016821|UniProtKB=H2R5J1	Protein kinase, AMP-activated, alpha 1 catalytic subunit	ISS			PTHR24343:SF306	5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1
P00048	PI3 kinase pathway	P01202	p85	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	IDA	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00560	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01142	p90RSK	BOVIN|Ensembl=ENSBTAG00000009175|UniProtKB=E1BLQ5	Uncharacterized protein	ISS	15116068	PubMed	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	PANTR|Ensembl=ENSPTRG00000021048|UniProtKB=H2R3C9	Uncharacterized protein	ISS	9783586	PubMed	PTHR10814:SF23	TRANSDUCIN-LIKE ENHANCER PROTEIN 1
P00018	EGF receptor signaling pathway	P00555	MKK4,7	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00057	Wnt signaling pathway	P01471	alpha-catenin	TAKRU|Ensembl=ENSTRUG00000002863|UniProtKB=H2S2N9	Uncharacterized protein	ISS	1638632	PubMed	PTHR18914:SF29	CATENIN ALPHA-2
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Ensembl=ENSBTAG00000001067|UniProtKB=E1BAB4	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	IDA	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00029	Huntington disease	P00807	Actin	ASHGO|EnsemblGenome=AGOS_ABR222W|UniProtKB=Q75D00	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00006	Apoptosis signaling pathway	P00307	ELF2alpha	DANRE|ZFIN=ZDB-GENE-030131-283|UniProtKB=Q9I9E9	Eukaryotic translation initiation factor 2, subunit 1 alpha	ISS	10889505	PubMed	PTHR10602:SF0	EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	TAS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04552	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00036	Interleukin signaling pathway	P00965	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00058	mRNA splicing	P01473	U6	MACMU|Ensembl=ENSMMUG00000016301|UniProtKB=F7GUG7	Uncharacterized protein	ISS	9328476	PubMed	PTHR14212:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3
P00005	Angiogenesis	P00240	FRS-2	MONDO|Ensembl=ENSMODG00000020378|UniProtKB=F7F6D5	Uncharacterized protein	ISS	10464310	PubMed	PTHR21258:SF40	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00055	Transcription regulation by bZIP transcription factor	P01390	TFIIA complex	ANOGA|EnsemblGenome=AGAP004370|UniProtKB=Q7QA87	Transcription initiation factor IIA subunit 2	ISS	95241493	PubMed	PTHR10966:SF0	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	MACMU|Ensembl=ENSMMUG00000012610|UniProtKB=F7F5C0	Uncharacterized protein	ISS	12645661	PubMed	PTHR44562:SF1	SUPPRESSOR OF CYTOKINE SIGNALING 6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CAEEL|WormBase=WBGene00000064|UniProtKB=P10984	Actin-2	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00010	B cell activation	P00379	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00010	B cell activation	P00384	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00052	TGF-beta signaling pathway	P01286	TGFbeta	XENTR|Xenbase=XB-GENE-486014|UniProtKB=F7APG6	Uncharacterized protein (Fragment)	ISS	9759503	PubMed	PTHR11848:SF135	BONE MORPHOGENETIC PROTEIN 7
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00047	PDGF signaling pathway	P01168	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01089	VAChT	DROME|FlyBase=FBgn0043005|UniProtKB=Q9VCJ5	Portabella	IC	21863848	PubMed	PTHR23506:SF4	PORTABELLA
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	CHICK|Ensembl=ENSGALG00000003267|UniProtKB=Q6DV79	Signal transducer and activator of transcription 3	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P05730	Endogenous cannabinoid signaling	P05748	mGluR	MOUSE|MGI=MGI=1351342|UniProtKB=Q3UVX5	Metabotropic glutamate receptor 5	ISS	12488551	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00021	FGF signaling pathway	P00628	JNK1-3	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00023	General transcription regulation	P00658	TBP-associated factors	ARATH|TAIR=AT1G54360|UniProtKB=F4HVA6	Transcription initiation factor TFIID subunit 6b	ISS			PTHR10221:SF9	TAF6-LIKE RNA POLYMERASE II P300/CBP-ASSOCIATED FACTOR-ASSOCIATED FACTOR 65 KDA SUBUNIT 6L
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	STRPU|EnsemblGenome=SPU_018419|UniProtKB=W4YRI6	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00114	actin	TRIAD|EnsemblGenome=TriadG56111|UniProtKB=B3RX77	Non-muscle actin 6.2	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00036	Interleukin signaling pathway	P00965	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IC	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	RAT|RGD=620441|UniProtKB=P50230	C-C motif chemokine 4	ISS			PTHR12015:SF145	C-C MOTIF CHEMOKINE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	CANLF|Ensembl=ENSCAFG00000011625|UniProtKB=F1PDD9	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00045	Notch signaling pathway	P01101	Su(H)	MACMU|Ensembl=ENSMMUG00000015828|UniProtKB=F7CE90	Recombining binding protein suppressor of hairless isoform 4	ISS	12145413	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00048	PI3 kinase pathway	P01192	p110	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00558	SOS	DICDI|dictyBase=DDB_G0284329|UniProtKB=Q54PQ4	Ras guanine nucleotide exchange factor A	IGI			PTHR23113:SF236	RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR A
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00236	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01455	Smad4	PANTR|Ensembl=ENSPTRG00000016485|UniProtKB=H2QQ88	Mothers against decapentaplegic homolog	ISS	12736218	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	MOUSE|MGI=MGI=95770|UniProtKB=P30678	Guanine nucleotide-binding protein subunit alpha-15	RCA			PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P04376	5HT4 type receptor mediated signaling pathway	P04431	5HT transporter	BOVIN|Gene=SLC6A4|UniProtKB=Q9XT49	Sodium-dependent serotonin transporter	ISS	14653308	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000003364|UniProtKB=F6ZPQ4	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00056	VEGF signaling pathway	P01417	Raf	CAEEL|WormBase=WBGene00003030|UniProtKB=Q07292	Raf homolog serine/threonine-protein kinase	ISS	125651	gi	PTHR44000:SF2	RAF HOMOLOG SERINE/THREONINE-PROTEIN KINASE PHL
P00059	p53 pathway	P04622	Sin3	PANTR|Ensembl=ENSPTRG00000007300|UniProtKB=H2R491	SIN3 homolog A, transcription regulator	ISS	10441327	PubMed	PTHR12346:SF2	PAIRED AMPHIPATHIC HELIX PROTEIN SIN3A
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00029	Huntington disease	P00787	MAPKK4	BOVIN|Ensembl=ENSBTAG00000012103|UniProtKB=A5PJP8	MAP2K4 protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	MACMU|Ensembl=ENSMMUG00000009679|UniProtKB=F6YBQ8	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00049	Parkinson disease	P01227	20S proteasome	BOVIN|Ensembl=ENSBTAG00000014440|UniProtKB=Q3ZCK9	Proteasome subunit alpha type-4	ISS	12859888	PubMed	PTHR11599:SF13	PROTEASOME SUBUNIT ALPHA TYPE-4
P04392	P53 pathway feedback loops 1	G04685	p73DeltaN	CANLF|Ensembl=ENSCAFG00000013961|UniProtKB=F1PL57	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	ISS	14744463	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	LEIMA|EnsemblGenome=LmjF.35.4010|UniProtKB=Q9GNR4	Protein kinase A catalytic subunit isoform 1	IC	10553940	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	MONDO|Ensembl=ENSMODG00000001807|UniProtKB=F6Y7R9	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05972	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00048	PI3 kinase pathway	P01187	IR	BOVIN|Ensembl=ENSBTAG00000012687|UniProtKB=F1MV64	Tyrosine-protein kinase receptor	ISS	11182407	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g242065|UniProtKB=A7S0V7	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IC	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04393	Ras Pathway	P04558	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	IDA	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00009	Axon guidance mediated by netrin	P00360	DCC/UNC-40	RAT|RGD=2492|UniProtKB=Q63155	Netrin receptor DCC	IDA	8861902	PubMed	PTHR44146:SF3	NETRIN RECEPTOR DCC
P05918	p38 MAPK pathway	P06026	MEKK4	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS	9305639	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	NEUCR|EnsemblGenome=EFNCRG00000006242|UniProtKB=Q12641	Pyrroline-5-carboxylate reductase	ISS			PTHR11645:SF0	PYRROLINE-5-CARBOXYLATE REDUCTASE
P00021	FGF signaling pathway	P00643	Raf-1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00024	Glycolysis	P00678	Enolase	HUMAN|HGNC=3353|UniProtKB=P09104	Gamma-enolase	IDA	5803011	gi	PTHR11902:SF10	GAMMA-ENOLASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ANOGA|EnsemblGenome=AGAP001676|UniProtKB=Q7PXZ8	AGAP001676-PA	IC	11889126	PubMed	PTHR11937:SF368	ACTIN, INDIRECT FLIGHT MUSCLE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	94179345	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00018	EGF receptor signaling pathway	G01511	SPRY	BOVIN|Ensembl=ENSBTAG00000008250|UniProtKB=A2VDU1	Protein sprouty homolog 4	ISS	12027893	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00729	Goalpha	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	HUMAN|HGNC=10451|UniProtKB=P23921	Ribonucleoside-diphosphate reductase large subunit	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00049	Parkinson disease	P01242	Casein kinase I	YEAST|SGD=S000006125|UniProtKB=P29295	Casein kinase I homolog HRR25	IDA	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00053	T cell activation	P01307	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00047	PDGF signaling pathway	P01174	Rho	CHICK|Ensembl=ENSGALG00000009825|UniProtKB=F1NEG5	Uncharacterized protein	ISS			PTHR14166:SF15	SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01026	KA	DANRE|Ensembl=ENSDARG00000070511|UniProtKB=E7F5R2	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF282	GLUTAMATE RECEPTOR-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00057	Wnt signaling pathway	P01448	CBP	ARATH|TAIR=AT1G67220|UniProtKB=Q9FYH1	Histone acetyltransferase HAC2	IDA	10823891	PubMed	PTHR13808:SF6	HISTONE ACETYLTRANSFERASE HAC2
P00020	FAS signaling pathway	P00610	MKK4	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	TAS	15531926	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00021	FGF signaling pathway	P00644	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00012	Cadherin signaling pathway	P00464	Fyn	DANRE|ZFIN=ZDB-GENE-050706-89|UniProtKB=F1RDG9	Tyrosine-protein kinase fynb	ISS	9741627	PubMed	PTHR24418:SF242	TYROSINE-PROTEIN KINASE FYNB
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	8387895	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MACMU|Gene=FPR3|UniProtKB=P79191	N-formyl peptide receptor 3 (Fragment)	IC			PTHR24225:SF16	N-FORMYL PEPTIDE RECEPTOR 3
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01438	PP2A	CHICK|Ensembl=ENSGALG00000011840|UniProtKB=F1NLM6	Uncharacterized protein	ISS	11007767	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00036	Interleukin signaling pathway	P00967	c-fos	MACMU|Ensembl=ENSMMUG00000010574|UniProtKB=A5A6H2	C-fos	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	PANTR|Ensembl=ENSPTRG00000009796|UniProtKB=H2QE47	Casein kinase 1, delta	ISS	11437445	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	HUMAN|HGNC=173|UniProtKB=P27037	Activin receptor type-2A	TAS	9395284	PubMed	PTHR23255:SF64	ACTIVIN RECEPTOR TYPE-2A
P00029	Huntington disease	P00797	p53	DANRE|ZFIN=ZDB-GENE-990415-270|UniProtKB=P79734	Cellular tumor antigen p53	ISS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P04393	Ras Pathway	P04543	MEKK1/4	CANLF|Ensembl=ENSCAFG00000000760|UniProtKB=E2R9L4	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00030	Hypoxia response via HIF activation	P00819	AKT	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	TAS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00927	Rac	DICPU|Gene=DICPUDRAFT_92985|UniProtKB=F1A084	Putative uncharacterized protein rac1A	ISS	8649368	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00045	Notch signaling pathway	P01108	Nicastrin	RAT|RGD=631418|UniProtKB=Q8CGU6	Nicastrin	TAS	10993067	PubMed	PTHR21092:SF0	NICASTRIN
P00021	FGF signaling pathway	P00624	14-3-3	SCHMA|EnsemblGenome=Smp_034840|UniProtKB=G4V8A9	14-3-3 epsilon	IGI	11172812	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	HUMAN|HGNC=7577|UniProtKB=P12883	Myosin-7	ISS	10938134	PubMed	PTHR13140:SF344	MYOSIN-7
P05918	p38 MAPK pathway	P06013	ELK	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	11050086	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00021	FGF signaling pathway	P00644	p38	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	IDA	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00052	TGF-beta signaling pathway	P01275	P38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02771	Pyrimidine Metabolism	P03129	Aminotransferase	RAT|RGD=620948|UniProtKB=P50554	4-aminobutyrate aminotransferase, mitochondrial	IDA	8133261	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P02725	Allantoin degradation	P02821	Allantoate amidohydrolase	MACMU|Ensembl=ENSMMUG00000004632|UniProtKB=F6TE28	Uncharacterized protein	ISS			PTHR12045:SF3	ALLANTOICASE-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	RAT|RGD=628852|UniProtKB=Q02294	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	15079861	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	HUMAN|HGNC=4543|UniProtKB=P32298	G protein-coupled receptor kinase 4	IDA	8288567	PubMed	PTHR24355:SF14	G PROTEIN-COUPLED RECEPTOR KINASE 4
P05915	Opioid proenkephalin pathway	P05992	met-Enkephalin	HUMAN|HGNC=8831|UniProtKB=P01210	Proenkephalin-A	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	IDA	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00021	FGF signaling pathway	P00643	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	MOUSE|MGI=MGI=88296|UniProtKB=O55017	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	14624853	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P02747	Histidine biosynthesis	P02989	Phosphoribosyl AMP cyclohydrolase	SCHPO|PomBase=SPBC29A3.02c|UniProtKB=O59667	Histidine biosynthesis bifunctional protein his7	ISS			PTHR42945:SF1	HISTIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN HISIE, CHLOROPLASTIC
P00057	Wnt signaling pathway	P01444	Wnt	XENTR|Xenbase=XB-GENE-480396|UniProtKB=F7DI28	Protein Wnt (Fragment)	ISS	11266476	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P02746	Heme biosynthesis	P02973	Uroporphyrinogen methyltransferase	GLOVI|Gene=BAC90521|UniProtKB=Q7NHF7	Uroporphyrin-III C-methyltransferase	ISS			PTHR21091:SF16	SIROHEME SYNTHASE
P02723	Adenine and hypoxanthine salvage pathway	P02809	Xanthine dehydrogenase	DEIRA|EnsemblGenome=DR_A0178|UniProtKB=Q9RYX6	Xanthine dehydrogenase molybdopterin binding subunit	ISS			PTHR11908:SF121	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04393	Ras Pathway	P04555	PDK	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	15210700	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	IDA	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00009	Axon guidance mediated by netrin	P00363	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00833	RGS	HUMAN|HGNC=9995|UniProtKB=O14921	Regulator of G-protein signaling 13	IDA	8756726	PubMed	PTHR10845:SF32	REGULATOR OF G-PROTEIN SIGNALING 13
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	ORYSJ|EnsemblGenome=OS01G0805900|UniProtKB=P45960	Tubulin beta-4 chain	ISS	12932731	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	BOVIN|Ensembl=ENSBTAG00000008429|UniProtKB=F1ML31	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF4	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00552	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00047	PDGF signaling pathway	P01160	IP3 receptor	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	G01535	PIG3	NEUCR|EnsemblGenome=EFNCRG00000005204|UniProtKB=Q7RZ31	Quinone oxidoreductase	TAS	12932731	PubMed	PTHR42975:SF1	QUINONE OXIDOREDUCTASE-RELATED
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00059	p53 pathway	P01481	ATM/ATR	EMENI|EnsemblGenome=CADANIAG00000506|UniProtKB=C8VB89	UVSB [Source:UniProtKB/TrEMBLAcc:Q9UV56]	ISS			PTHR11139:SF69	SERINE/THREONINE-PROTEIN KINASE ATR
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346347|UniProtKB=Q9WVS8	Mitogen-activated protein kinase 7	ISS	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	YEAST|SGD=S000003272|UniProtKB=P14681	Mitogen-activated protein kinase KSS1	ISS			PTHR24055:SF338	MITOGEN-ACTIVATED PROTEIN KINASE KSS1
P00036	Interleukin signaling pathway	P00977	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00052	TGF-beta signaling pathway	P01286	TGFbeta	RAT|RGD=621512|UniProtKB=P55108	Growth/differentiation factor 10	TAS	9759503	PubMed	PTHR11848:SF145	GROWTH/DIFFERENTIATION FACTOR 10
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00029	Huntington disease	G01533	Bax	MOUSE|MGI=MGI=99702|UniProtKB=Q07813	Apoptosis regulator BAX	TAS	14963330	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00060	Ubiquitin proteasome pathway	P01491	E2	HUMAN|HGNC=12490|UniProtKB=O14933	Ubiquitin/ISG15-conjugating enzyme E2 L6	ISS	11078524	PubMed	PTHR24068:SF43	UBIQUITIN/ISG15-CONJUGATING ENZYME E2 L6
P00029	Huntington disease	P00790	beta-Tubulin	YEAST|SGD=S000001857|UniProtKB=P02557	Tubulin beta chain	TAS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00004	Alzheimer disease-presenilin pathway	P00128	Erb-B4	MONDO|Ensembl=ENSMODG00000015755|UniProtKB=F6ZSZ9	Uncharacterized protein (Fragment)	ISS	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00005	Angiogenesis	P00218	STAT1	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00029	Huntington disease	P00790	beta-Tubulin	HUMAN|HGNC=20778|UniProtKB=P07437	Tubulin beta chain	TAS	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	TRIAD|EnsemblGenome=TriadG30170|UniProtKB=B3S6H7	Serine/threonine-protein phosphatase	ISS	10433257	PubMed	PTHR11668:SF402	SERINE/THREONINE-PROTEIN PHOSPHATASE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01420	FAK	HUMAN|HGNC=9611|UniProtKB=Q05397	Focal adhesion kinase 1	IDA	9182576	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P04397	p53 pathway by glucose deprivation	P04639	AMPK	HUMAN|HGNC=9385|UniProtKB=P54619	5'-AMP-activated protein kinase subunit gamma-1	ISS			PTHR13780:SF38	5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1
P00005	Angiogenesis	P00217	STAT3	MOUSE|MGI=MGI=103038|UniProtKB=P42227	Signal transducer and activator of transcription 3	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00021	FGF signaling pathway	P00624	14-3-3	MOUSE|MGI=MGI=109194|UniProtKB=P68510	14-3-3 protein eta	IGI	14593000	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	IC	http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00052	TGF-beta signaling pathway	P01286	TGFbeta	HUMAN|HGNC=1072|UniProtKB=P22003	Bone morphogenetic protein 5	TAS	9759503	PubMed	PTHR11848:SF139	BONE MORPHOGENETIC PROTEIN 5
P00057	Wnt signaling pathway	P01448	CBP	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00019	Endothelin signaling pathway	P00566	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01443	Phospholipase C	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00020	FAS signaling pathway	P00615	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04542	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	ORYSJ|EnsemblGenome=OS01G0293000|UniProtKB=Q9LGU6	S-adenosylmethionine synthase 3	ISS			PTHR11964:SF16	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	MONDO|Ensembl=ENSMODG00000005255|UniProtKB=F7G800	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000019277|UniProtKB=H2QUQ1	Uncharacterized protein	ISS	1321498	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P04393	Ras Pathway	P04558	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IDA	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	BOVIN|Ensembl=ENSBTAG00000007996|UniProtKB=E1BE22	Uncharacterized protein	ISS	12441358	PubMed	PTHR24247:SF114	5-HYDROXYTRYPTAMINE RECEPTOR 6
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00036	Interleukin signaling pathway	P00987	SRF	CANLF|Ensembl=ENSCAFG00000001829|UniProtKB=F1PH12	Uncharacterized protein	ISS	15326221	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00780	Microtubule	ORYSJ|EnsemblGenome=OS06G0671900|UniProtKB=Q40665	Tubulin beta-3 chain	IDA	12932731	PubMed	PTHR11588:SF245	TUBULIN BETA-4 CHAIN-RELATED
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	HUMAN|HGNC=4579|UniProtKB=P39086	Glutamate receptor ionotropic, kainate 1	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	HUMAN|HGNC=1460|UniProtKB=Q9UQM7	Calcium/calmodulin-dependent protein kinase type II subunit alpha	ISS	10092204	PubMed	PTHR43940:SF5	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	8649368	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IDA	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00020	FAS signaling pathway	P00620	CytochromeC	ARATH|TAIR=AT5G40810|UniProtKB=Q9FKS5	Cytochrome c1 2, heme protein, mitochondrial	ISS	15163634	PubMed	PTHR10266:SF6	CYTOCHROME C1 1, HEME PROTEIN, MITOCHONDRIAL-RELATED
P04397	p53 pathway by glucose deprivation	P04641	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	MONDO|Ensembl=ENSMODG00000003587|UniProtKB=F7FPX9	Uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00019	Endothelin signaling pathway	P00586	Gq	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	DROME|FlyBase=FBgn0019947|UniProtKB=O02194	Presenilin homolog	TAS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00906	Rap1	MOUSE|MGI=MGI=97852|UniProtKB=P62835	Ras-related protein Rap-1A	ISS	1904317	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00034	Integrin signalling pathway	P00918	Caveolin	BOVIN|Ensembl=ENSBTAG00000017869|UniProtKB=P79132	Caveolin-1	ISS	9741627	PubMed	PTHR10844:SF18	CAVEOLIN-1
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346347|UniProtKB=Q9WVS8	Mitogen-activated protein kinase 7	ISS	12912994	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00010	B cell activation	P00383	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00010	B cell activation	P00388	PLC gamma2	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	IGI	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00018	EGF receptor signaling pathway	P00560	Raf-1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IGI	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00383	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IDA	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	BOVIN|Ensembl=ENSBTAG00000011198|UniProtKB=P61287	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	ISS	8392016	PubMed	PTHR11668:SF204	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-GAMMA CATALYTIC SUBUNIT
P04393	Ras Pathway	P04553	PAK	ORNAN|Ensembl=ENSOANG00000002406|UniProtKB=F7BAS2	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	YEAST|SGD=S000001295|UniProtKB=P07278	cAMP-dependent protein kinase regulatory subunit	IC	176892	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00010	B cell activation	P00402	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00053	T cell activation	P01332	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IDA	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	MACMU|Ensembl=ENSMMUG00000004886|UniProtKB=F7AGT9	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00639	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00057	Wnt signaling pathway	P01448	CBP	ARATH|TAIR=AT3G12980|UniProtKB=Q9LE42	Histone acetyltransferase HAC5	IDA	10664585	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P02772	Pyruvate metabolism	P03137	Citrate Lyase	PANTR|Ensembl=ENSPTRG00000023148|UniProtKB=H2R314	Uncharacterized protein	ISS			PTHR23118:SF0	ATP-CITRATE SYNTHASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00036	Interleukin signaling pathway	P00990	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04496	Mdm2	MACMU|Ensembl=ENSMMUG00000014193|UniProtKB=F7AKR9	Uncharacterized protein	ISS	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	CHICK|Ensembl=ENSGALG00000008898|UniProtKB=F1P2J9	Uncharacterized protein	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P02738	De novo purine biosynthesis	P02891	GDP kinase	RAT|RGD=61896|UniProtKB=O88426	Nucleoside diphosphate kinase 6 (Fragment)	ISS			PTHR11349:SF70	NUCLEOSIDE DIPHOSPHATE KINASE 6
P00049	Parkinson disease	P01211	ERK	ORYSJ|EnsemblGenome=OS02G0148100|UniProtKB=Q6Z437	Mitogen-activated protein kinase 3	IDA	9836510	gi	PTHR24055:SF216	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00780	Microtubule	CAEBR|Gene=CBG18319|UniProtKB=A8XSF1	Protein CBR-TBB-1	ISS	12932731	PubMed	PTHR11588:SF157	TUBULIN, BETA
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	IDA	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=99217|UniProtKB=P55288	Cadherin-11	IDA	8120095	PubMed	PTHR24027:SF85	CADHERIN-11
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00010	B cell activation	P00371	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00807	Actin	STRPU|EnsemblGenome=SPU_006797|UniProtKB=W4XTP5	Uncharacterized protein	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DICDI|dictyBase=DDB_G0277143|UniProtKB=P36408	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02728	Arginine biosynthesis	P02841	argininosuccinate lyase	PSEAE|EnsemblGenome=PA5263|UniProtKB=P50987	Argininosuccinate lyase	ISS			PTHR43814:SF1	ARGININOSUCCINATE LYASE
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	HUMAN|HGNC=9300|UniProtKB=P62714	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	DROME|FlyBase=FBgn0004396|UniProtKB=P29747	Cyclic AMP response element-binding protein A	RCA			PTHR22952:SF147	CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN A
P00011	Blood coagulation	P00458	GP IIIa	MACMU|Ensembl=ENSMMUG00000003289|UniProtKB=F7FG54	Integrin beta	ISS	124968	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00018	EGF receptor signaling pathway	P00543	ERK1-2	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IGI	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	ORYSJ|EnsemblGenome=OS10G0563700|UniProtKB=Q7XC37	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05918	p38 MAPK pathway	P06044	GADD45	HUMAN|HGNC=4095|UniProtKB=P24522	Growth arrest and DNA damage-inducible protein GADD45 alpha	IDA	9827804	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P00009	Axon guidance mediated by netrin	P00359	NFAT	RAT|RGD=1310749|UniProtKB=D3Z9H7	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	ISS	12015605	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04393	Ras Pathway	P04552	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00004	Alzheimer disease-presenilin pathway	P00137	Tip60	CANLF|Ensembl=ENSCAFG00000013299|UniProtKB=E2RE71	Histone acetyltransferase	ISS	11441186	PubMed	PTHR10615:SF124	HISTONE ACETYLTRANSFERASE KAT5
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	HUMAN|HGNC=7849|UniProtKB=P15531	Nucleoside diphosphate kinase A	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ARATH|TAIR=AT5G59370|UniProtKB=P53494	Actin-4	ISS	10974003	PubMed	PTHR11937:SF366	ACTIN-4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	DROME|FlyBase=FBgn0019947|UniProtKB=O02194	Presenilin homolog	IDA	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	PANTR|Ensembl=ENSPTRG00000006510|UniProtKB=H2Q8K1	Presenilin	ISS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	TAS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00057	Wnt signaling pathway	P01437	TCF	PANTR|Ensembl=ENSPTRG00000012128|UniProtKB=H2QI87	Uncharacterized protein	ISS	11266476	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	CANLF|Ensembl=ENSCAFG00000015905|UniProtKB=E2QUH6	Uncharacterized protein	ISS	9388255	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00018	EGF receptor signaling pathway	P00558	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05731	GABA-B receptor II signaling	P05754	Ggamma	RAT|RGD=621515|UniProtKB=P61954	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	ISS	2122451	PubMed	PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	RCA	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=11433|UniProtKB=Q16623	Syntaxin-1A	ISS	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00048	PI3 kinase pathway	P01189	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04393	Ras Pathway	P04546	GSK3	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02783	Tryptophan biosynthesis	P03209	Anthranilate phosphoribosyl transferase	STRCO|EnsemblGenome=CAB39874|UniProtKB=O68608	Anthranilate phosphoribosyltransferase 1	ISS			PTHR43285:SF2	ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE
P04393	Ras Pathway	P04557	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05731	GABA-B receptor II signaling	P05754	Ggamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	RCA	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00057	Wnt signaling pathway	P01444	Wnt	CANLF|Ensembl=ENSCAFG00000005291|UniProtKB=E2QXQ3	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MACMU|Ensembl=ENSMMUG00000001458|UniProtKB=F7BKH1	Uncharacterized protein	ISS	12473693	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00009	Axon guidance mediated by netrin	P00357	Netrin	HUMAN|HGNC=14288|UniProtKB=Q96CW9	Netrin-G2	ISS			PTHR10574:SF27	NETRIN-G2
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	MOUSE|MGI=MGI=98848|UniProtKB=P12656	Thyrotropin subunit beta	ISS	15927770	PubMed	PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	176892	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	DROME|FlyBase=FBgn0264000|UniProtKB=M9PHV5	Glutamate receptor IB, isoform B	ISS	12941441	PubMed	PTHR18966:SF270	GLUTAMATE RECEPTOR 1-RELATED
P00011	Blood coagulation	P00460	FXI	MOUSE|MGI=MGI=99481|UniProtKB=Q91Y47	Coagulation factor XI	ISS	13811665	gi	PTHR44459:SF1	COAGULATION FACTOR XI
P00048	PI3 kinase pathway	P01188	Gbetagamma	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00005	Angiogenesis	P00238	Ras	PANTR|Ensembl=ENSPTRG00000034469|UniProtKB=H2Q2V0	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00057	Wnt signaling pathway	P01455	Smad4	HUMAN|HGNC=6770|UniProtKB=Q13485	Mothers against decapentaplegic homolog 4	IDA	10693808	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	RCA	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	HUMAN|HGNC=8931|UniProtKB=P15735	Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	IDA	1370475	PubMed	PTHR44087:SF2	PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, LIVER/TESTIS ISOFORM
P00036	Interleukin signaling pathway	P00970	Interleukin	HUMAN|HGNC=6005|UniProtKB=Q9HBE4	Interleukin-21	IC	11081504	PubMed	PTHR14356:SF2	INTERLEUKIN-21
P00006	Apoptosis signaling pathway	P00310	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IDA	12660731	PubMed	PTHR10048:SF14	PI-3 KINASE
P04398	p53 pathway feedback loops 2	P04651	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10557357	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01167	Ets	HUMAN|HGNC=3318|UniProtKB=P78545	ETS-related transcription factor Elf-3	ISS	15298723	PubMed	PTHR11849:SF13	ETS-RELATED TRANSCRIPTION FACTOR ELF-3
P00053	T cell activation	P01320	PLC-gamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00019	Endothelin signaling pathway	P00586	Gq	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01448	CBP	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00748	Gbeta5L	PANTR|Ensembl=ENSPTRG00000007084|UniProtKB=H2Q9G5	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04398	p53 pathway feedback loops 2	P04665	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00383	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00024	Glycolysis	P00675	Pyruvate kinase	RAT|RGD=3336|UniProtKB=P12928	Pyruvate kinase PKLR	RCA			PTHR11817:SF31	PYRUVATE KINASE PKLR
P06664	Gonadotropin-releasing hormone receptor pathway	G06666	Fosb	MOUSE|MGI=MGI=95575|UniProtKB=P13346	Protein fosB	RCA			PTHR23351:SF3	PROTEIN FOSB
P00057	Wnt signaling pathway	P01435	SWI/SNF	PLAF7|EnsemblGenome=PFB0730w|UniProtKB=O96239	DEAD/DEAH box helicase, putative	IDA	11532957	PubMed	PTHR10799:SF854	ATP-DEPENDENT HELICASE BRM
P00010	B cell activation	P00373	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	90172230	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IDA	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00060	Ubiquitin proteasome pathway	P01490	E3	CANLF|Ensembl=ENSCAFG00000010870|UniProtKB=E2QUU3	Uncharacterized protein	ISS			PTHR11254:SF352	UBIQUITIN-PROTEIN LIGASE E3B
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	BOVIN|Ensembl=ENSBTAG00000030182|UniProtKB=G3X793	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	NEUCR|EnsemblGenome=EFNCRG00000003889|UniProtKB=P38673	Actin-like protein	IC	14684598	PubMed	PTHR11937:SF46	ALPHA-CENTRACTIN
P05915	Opioid proenkephalin pathway	P05993	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P02748	Isoleucine biosynthesis	P02997	Acetolactate synthase	SULSO|EnsemblGenome=SSO1012|UniProtKB=Q97ZB3	Acetolactate synthase large subunit homolog (IlvB-3)	ISS			PTHR42981:SF2	PYRUVATE DEHYDROGENASE  UBIQUINONE
P00048	PI3 kinase pathway	P01181	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00049	Parkinson disease	G01547	DAT	RAT|RGD=3715|UniProtKB=P23977	Sodium-dependent dopamine transporter	IDA	15135042	PubMed	PTHR11616:SF38	SODIUM-DEPENDENT DOPAMINE TRANSPORTER
P00054	Toll receptor signaling pathway	P01358	ERK1	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00790	beta-Tubulin	CHICK|Ensembl=ENSGALG00000007447|UniProtKB=P09207	Tubulin beta-6 chain	TAS	9454836	PubMed	PTHR11588:SF112	TUBULIN BETA-1 CHAIN
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	PANTR|Ensembl=ENSPTRG00000002149|UniProtKB=H2R0U9	Uncharacterized protein	ISS	15226293	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00048	PI3 kinase pathway	P01199	Galpha	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS			PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01407	Erk	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	ANOGA|EnsemblGenome=AGAP007136|UniProtKB=Q7QIY9	AGAP007136-PA (Fragment)	IDA			PTHR24247:SF117	5-HYDROXYTRYPTAMINE RECEPTOR 2A-RELATED
P04393	Ras Pathway	P04578	Rho	PANTR|Ensembl=ENSPTRG00000014922|UniProtKB=H2QML4	Uncharacterized protein	ISS	12169092	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P04372	5-Hydroxytryptamine degredation	P04401	Monoamine Oxidase	XENTR|Xenbase=XB-GENE-5749883|UniProtKB=F6V922	Uncharacterized protein (Fragment)	ISS	8602220	PubMed	PTHR43563:SF2	AMINE OXIDASE  FLAVIN-CONTAINING
P00048	PI3 kinase pathway	P01190	PDK1 ACT	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	15531926	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00025	Hedgehog signaling pathway	P00682	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P02752	Mannose metabolism	P03018	Mannose 1-P guanylyl transferase	CANLF|Ensembl=ENSCAFG00000015541|UniProtKB=E2R1D1	Uncharacterized protein	ISS	12477932	PubMed	PTHR22572:SF104	MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE ALPHA
P00021	FGF signaling pathway	P00644	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00029	Huntington disease	P00811	Arp2/3 complex	PANTR|Ensembl=ENSPTRG00000019449|UniProtKB=H2QV01	Actin related protein 2/3 complex, subunit 1B, 41kDa	ISS	9618202	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00018	EGF receptor signaling pathway	P00543	ERK1-2	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IGI	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00012	Cadherin signaling pathway	P00473	P120	MOUSE|MGI=MGI=105100|UniProtKB=P30999	Catenin delta-1	ISS			PTHR10372:SF6	CATENIN DELTA-1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95808|UniProtKB=P23818	Glutamate receptor 1	ISS	12941441	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00034	Integrin signalling pathway	P00925	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02769	Purine metabolism	P03117	5'-AMP Deaminase	PANTR|Ensembl=ENSPTRG00000003355|UniProtKB=H2Q364	Adenosine monophosphate deaminase 3	ISS	1420359	PubMed	PTHR11359:SF2	AMP DEAMINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	RAT|RGD=3694|UniProtKB=Q01827	Synaptic vesicular amine transporter	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00047	PDGF signaling pathway	P01163	c-Jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04398	p53 pathway feedback loops 2	P04665	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01174	Rho	RAT|RGD=68416|UniProtKB=Q63744	Rho GTPase-activating protein 7	ISS			PTHR12659:SF2	RHO GTPASE-ACTIVATING PROTEIN 7
P00047	PDGF signaling pathway	P01167	Ets	MOUSE|MGI=MGI=95455|UniProtKB=P27577	Protein C-ets-1	ISS	9157999	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	RAT|RGD=620966|UniProtKB=Q62925	Mitogen-activated protein kinase kinase kinase 1	IGI	12168099	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00558	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IGI	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00623	FGF	MOUSE|MGI=MGI=109183|UniProtKB=P61329	Fibroblast growth factor 12	IEP	9232594	PubMed	PTHR11486:SF17	FIBROBLAST GROWTH FACTOR 12
P00030	Hypoxia response via HIF activation	P00814	P300	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	IDA	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00034	Integrin signalling pathway	P00920	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00057	Wnt signaling pathway	P01443	Phospholipase C	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00036	Interleukin signaling pathway	P00976	GSK3	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00005	Angiogenesis	P00256	PLC-gamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00005	Angiogenesis	P00249	PAK	CAEEL|WormBase=WBGene00003911|UniProtKB=Q17850	Serine/threonine-protein kinase pak-1	ISS			PTHR24361:SF456	P21-ACTIVATED KINASE, ISOFORM F
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	IC	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	ANOGA|EnsemblGenome=AGAP000138|UniProtKB=Q66T33	AGAP000138-PB	IC	85270494	PubMed	PTHR18945:SF531	NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA4, ISOFORM H
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	IC	96149441	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	PANTR|Ensembl=ENSPTRG00000008874|UniProtKB=H2R9K6	Aldehyde dehydrogenase	ISS	14724059	PubMed	PTHR43570:SF15	ALDEHYDE DEHYDROGENASE, DIMERIC NADP-PREFERRING
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05731	GABA-B receptor II signaling	P05755	Gbeta	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00021	FGF signaling pathway	P00624	14-3-3	SCHMA|EnsemblGenome=Smp_034840|UniProtKB=G4V8A9	14-3-3 epsilon	IGI	21099905	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00045	Notch signaling pathway	P01103	Next	DANRE|ZFIN=ZDB-GENE-011128-4|UniProtKB=Q90Y54	Protein jagged-1b	ISS			PTHR44097:SF3	PROTEIN JAGGED-1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00907	ERK	MONDO|Ensembl=ENSMODG00000009766|UniProtKB=F6TFL4	Uncharacterized protein	ISS	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000010266|UniProtKB=F6PV18	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00005	Angiogenesis	P00203	Erk	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	PANTR|Ensembl=ENSPTRG00000004079|UniProtKB=H2R1Z2	Uncharacterized protein	ISS	4757780	gi	PTHR11792:SF22	BETA-ARRESTIN-1
P00060	Ubiquitin proteasome pathway	P01491	E2	ANOGA|EnsemblGenome=AGAP003857|UniProtKB=Q7QFT1	AGAP003857-PA	ISS			PTHR43898:SF1	UBIQUITIN-CONJUGATING ENZYME E2-17 KDA
P00012	Cadherin signaling pathway	P00470	F-actin	XENTR|GeneID=394982|UniProtKB=P20399	Actin, alpha cardiac muscle 2	ISS	11889139	PubMed	PTHR11937:SF263	ACTIN
P02787	Vitamin B6 metabolism	P03242	Threonine synthase	YEAST|SGD=S000000649|UniProtKB=P16120	Threonine synthase	IDA	11756443	PubMed	PTHR42690:SF1	THREONINE SYNTHASE-LIKE 2
P04386	Histamine H2 receptor mediated signaling pathway	P04489	H2	MACMU|Ensembl=ENSMMUG00000014245|UniProtKB=F7C4E6	Uncharacterized protein	ISS	11841575	PubMed	PTHR43893:SF5	HISTAMINE H2 RECEPTOR
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05730	Endogenous cannabinoid signaling	P05751	Galpha	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	ISS	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P05731	GABA-B receptor II signaling	P05755	Gbeta	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00046	Oxidative stress response	P01131	MKP5	PANTR|Ensembl=ENSPTRG00000023938|UniProtKB=H2R0P6	Serine/threonine/tyrosine interacting protein	ISS			PTHR10159:SF385	SERINE/THREONINE/TYROSINE-INTERACTING PROTEIN
P06664	Gonadotropin-releasing hormone receptor pathway	P06819	SMAD2-4	MOUSE|MGI=MGI=1201674|UniProtKB=Q8BUN5	Mothers against decapentaplegic homolog 3	RCA	9395284	PubMed	PTHR13703:SF25	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3
P00029	Huntington disease	P00775	Rac	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	CANLF|Gene=PSEN1|UniProtKB=Q6RH31	Presenilin-1	TAS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=105057|UniProtKB=P55284	Cadherin-5	IDA	8120095	PubMed	PTHR24027:SF89	CADHERIN-5
P00018	EGF receptor signaling pathway	P00559	MEK1-2	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IDA	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00054	Toll receptor signaling pathway	P01354	NFkappaB	MOUSE|MGI=MGI=1099800|UniProtKB=Q9WTK5	Nuclear factor NF-kappa-B p100 subunit	ISS	12574369	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10875333	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00010	B cell activation	P00391	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02751	Lysine biosynthesis	P03009	Aspartokinase	BACTN|EnsemblGenome=BT_2403|UniProtKB=Q8A541	Aspartokinase/homoserine dehydrogenase	ISS			PTHR21499:SF3	ASPARTOKINASE
P00006	Apoptosis signaling pathway	P00269	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DANRE|ZFIN=ZDB-GENE-040426-2280|UniProtKB=Q6P025	Gnb3 protein	ISS			PTHR19850:SF35	GNB3 PROTEIN
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04393	Ras Pathway	P04542	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01234	GRK	PANTR|Ensembl=ENSPTRG00000014187|UniProtKB=H2R714	Protein-serine/threonine kinase	ISS	10852916	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P00006	Apoptosis signaling pathway	P00302	ATF	CHICK|Ensembl=ENSGALG00000009287|UniProtKB=O93602	Cyclic AMP-dependent transcription factor ATF-2	ISS	11390664	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04397	p53 pathway by glucose deprivation	P04639	AMPK	BOVIN|Ensembl=ENSBTAG00000014387|UniProtKB=E1B986	Uncharacterized protein	ISS			PTHR10343:SF45	5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2
P00046	Oxidative stress response	P01129	JNK1/2	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	TAS	9851932	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00009	Axon guidance mediated by netrin	P00366	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P02746	Heme biosynthesis	P02980	Coproporphyrinogen Oxidase (oxygen dependent)	SYNY3|EnsemblGenome=BAA16863|UniProtKB=P72848	Oxygen-dependent coproporphyrinogen-III oxidase	ISS			PTHR10755:SF0	OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	CANLF|Ensembl=ENSCAFG00000007766|UniProtKB=E2R911	Uncharacterized protein	ISS			PTHR12595:SF8	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 9
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	20216076	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	ARATH|TAIR=AT5G61210|UniProtKB=Q9S7P9	SNAP25 homologous protein SNAP33	IC			PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05915	Opioid proenkephalin pathway	P05988	peptide E	HUMAN|HGNC=8831|UniProtKB=P01210	Proenkephalin-A	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P02736	Coenzyme A biosynthesis	P02882	Pantothenate cysteine ligase	FUSNN|EnsemblGenome=FN0711|UniProtKB=Q8RFI5	Phosphopantothenate--cysteine ligase	ISS			PTHR14359:SF6	PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE
P02775	Salvage pyrimidine ribonucleotides	P03155	Cytosine deaminase	BACSU|EnsemblGenome=BSU00180|UniProtKB=P21335	tRNA-specific adenosine deaminase	ISS			PTHR11079:SF149	TRNA-SPECIFIC ADENOSINE DEAMINASE
P04393	Ras Pathway	P04559	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00055	Transcription regulation by bZIP transcription factor	P01390	TFIIA complex	MONDO|Ensembl=ENSMODG00000003731|UniProtKB=F7EVS0	Uncharacterized protein	ISS	600519	OMIM	PTHR12694:SF7	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00021	FGF signaling pathway	P00645	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00057	Wnt signaling pathway	P01438	PP2A	BOVIN|Ensembl=ENSBTAG00000000754|UniProtKB=A2VDZ0	Protein phosphatase 2, regulatory subunit B', alpha isoform	ISS	10092233	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00628	JNK1-3	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00059	p53 pathway	P04609	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	14526383	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00018	EGF receptor signaling pathway	P00547	PP2A	CANLF|Ensembl=ENSCAFG00000006453|UniProtKB=F6X958	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00376	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00006	Apoptosis signaling pathway	P00274	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	SULSO|EnsemblGenome=SSO2044|UniProtKB=Q97WS2	Glutamate dehydrogenase	ISS			PTHR11606:SF13	GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	IDA	8925912	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CAEEL|WormBase=WBGene00004036|UniProtKB=G5EFI8	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	HUMAN|HGNC=1953|UniProtKB=P08173	Muscarinic acetylcholine receptor M4	ISS	8100450	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MONDO|Ensembl=ENSMODG00000004799|UniProtKB=F6VM87	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04395	Vasopressin synthesis	P04590	Vasopressin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00004	Alzheimer disease-presenilin pathway	P00165	E-cadherin N-terminal fragment	MACMU|Ensembl=ENSMMUG00000010393|UniProtKB=F7D992	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P00010	B cell activation	P00379	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02755	Methylmalonyl pathway	P03034	Methylmalonyl-CoA mutase	MACMU|Ensembl=ENSMMUG00000002458|UniProtKB=F7HGZ4	Methylmalonyl-CoA mutase, mitochondrial	ISS			PTHR42710:SF1	METHYLMALONYL-COA MUTASE, MITOCHONDRIAL
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CANLF|Ensembl=ENSCAFG00000008756|UniProtKB=F2Z4N8	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00006	Apoptosis signaling pathway	P00269	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02742	Tetrahydrofolate biosynthesis	P02944	Phosphoribosylglycinamide formyltransferase	PSEAE|EnsemblGenome=PA4314|UniProtKB=Q9HW87	Formyltetrahydrofolate deformylase	ISS			PTHR42706:SF1	FORMYLTETRAHYDROFOLATE DEFORMYLASE 1, MITOCHONDRIAL-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	RAT|RGD=1359613|UniProtKB=Q66HA2	Cyclic AMP-responsive element-binding protein 3-like protein 1	RCA			PTHR22952:SF24	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 1
P00057	Wnt signaling pathway	P01457	GBeta	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	9754712	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00030	Hypoxia response via HIF activation	P00819	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00892	Grb2	DROME|FlyBase=FBgn0004638|UniProtKB=Q08012	Protein enhancer of sevenless 2B	ISS	4504111	gi	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00010	B cell activation	P00371	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04397	p53 pathway by glucose deprivation	P04641	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DANRE|ZFIN=ZDB-GENE-030131-1229|UniProtKB=Q6DHS1	Actin, alpha 2, smooth muscle, aorta	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00036	Interleukin signaling pathway	P00990	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00924	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01347	MD-2	MOUSE|MGI=MGI=1341909|UniProtKB=Q9JHF9	Lymphocyte antigen 96	ISS			PTHR15218:SF0	LYMPHOCYTE ANTIGEN 96
P00048	PI3 kinase pathway	P01177	P110ACT	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CAEBR|Gene=CBG05858|UniProtKB=A8X1H0	Protein CBR-EGL-19 (Fragment)	ISS	11956331	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	DANRE|ZFIN=ZDB-GENE-030910-2|UniProtKB=Q7T1A1	Dopamine D2c receptor	ISS	2039532	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	METAC|EnsemblGenome=MA_0925|UniProtKB=Q8TS80	Aromatic amino acid transferase	ISS			PTHR43795:SF24	SUBFAMILY NOT NAMED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	IC	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04393	Ras Pathway	P04570	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01428	Frizzled	HUMAN|HGNC=4039|UniProtKB=Q9ULW2	Frizzled-10	IDA	8717036	PubMed	PTHR11309:SF86	FRIZZLED-10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=105372|UniProtKB=P49660	Somatostatin receptor type 4	IDA	12562507	PubMed	PTHR24229:SF52	SOMATOSTATIN RECEPTOR TYPE 4
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	ANOGA|EnsemblGenome=AGAP009680|UniProtKB=Q7Q1Q4	AGAP009680-PA	ISS			PTHR12458:SF8	CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20
P00056	VEGF signaling pathway	P01414	PLC-gamma	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00009	Axon guidance mediated by netrin	P00363	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	HUMAN|HGNC=143|UniProtKB=P68032	Actin, alpha cardiac muscle 1	IDA	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01188	Gbetagamma	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00045	Notch signaling pathway	P01099	Notch	PANTR|Ensembl=ENSPTRG00000010617|UniProtKB=H2QFL8	Notch 3	ISS	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8706|UniProtKB=Q9Y5G5	Protocadherin gamma-A8	IDA	8120095	PubMed	PTHR24028:SF72	PROTOCADHERIN GAMMA-A8
P00006	Apoptosis signaling pathway	P00276	TRAIL-R	PANTR|Ensembl=ENSPTRG00000020074|UniProtKB=H2QVW1	Tumor necrosis factor receptor superfamily, member 10a	ISS	11498783	PubMed	PTHR23097:SF179	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10A
P06959	CCKR signaling map	P07136	IL8	HUMAN|HGNC=6025|UniProtKB=P10145	Interleukin-8	RCA	18395088	PubMed	PTHR10179:SF70	INTERLEUKIN-8
P02740	De novo pyrimidine ribonucleotides biosythesis	P02927	Dihydrooratate oxidase	HALSA|EnsemblGenome=VNG_2507G|UniProtKB=Q9HMK2	Dihydroorotate dehydrogenase (quinone)	ISS			PTHR43517:SF1	DIHYDROOROTATE DEHYDROGENASE  QUINONE , MITOCHONDRIAL
P00021	FGF signaling pathway	P00645	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00038	JAK/STAT signaling pathway	P01027	STAT	PANTR|Ensembl=ENSPTRG00000009200|UniProtKB=H2QD20	Signal transducer and activator of transcription	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	RAT|RGD=69424|UniProtKB=Q99P84	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	12860966	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	CANLF|Ensembl=ENSCAFG00000013067|UniProtKB=E2RJA0	Uncharacterized protein	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00029	Huntington disease	P00796	Kainate receptor	MACMU|Ensembl=ENSMMUG00000017431|UniProtKB=F7HPP3	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01171	PLCgamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6880|UniProtKB=Q13164	Mitogen-activated protein kinase 7	IDA	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00048	PI3 kinase pathway	P01194	S6K	CANLF|Ensembl=ENSCAFG00000017679|UniProtKB=E2RMD8	Ribosomal protein S6 kinase	ISS	15116068	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	BOVIN|Ensembl=ENSBTAG00000006295|UniProtKB=P01223	Thyrotropin subunit beta	ISS	15927770	PubMed	PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95815|UniProtKB=P39087	Glutamate receptor ionotropic, kainate 2	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00053	T cell activation	P01320	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P05913	Enkephalin release	P05974	G-Protein (i)	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00025	Hedgehog signaling pathway	P00682	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00970	Interleukin	CHICK|Ensembl=ENSGALG00000009870|UniProtKB=F1NZN5	Interleukin	IC			PTHR45114:SF1	INTERLEUKIN-15
P00010	B cell activation	P00397	IKK	MACMU|Ensembl=ENSMMUG00000018476|UniProtKB=F6X938	Uncharacterized protein	ISS	14499113	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01468	APC	MOUSE|MGI=MGI=1346052|UniProtKB=Q9Z1K7	Adenomatous polyposis coli protein 2	IDA	10491393	PubMed	PTHR12607:SF3	ADENOMATOUS POLYPOSIS COLI PROTEIN 2
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00036	Interleukin signaling pathway	P00980	IRS1/2	PANTR|Ensembl=ENSPTRG00000012989|UniProtKB=H2QJJ4	Insulin receptor substrate 1	ISS	1311924	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00057	Wnt signaling pathway	P01456	beta-arrestin	BOVIN|Gene=ARRB2|UniProtKB=P32120	Beta-arrestin-2	IDA	12464600	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04630	PP2A	MOUSE|MGI=MGI=1321159|UniProtKB=P63330	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05990	K+ channel	BOVIN|Ensembl=ENSBTAG00000018193|UniProtKB=E1BHX8	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00018	EGF receptor signaling pathway	P00539	14-3-3	CHICK|Ensembl=ENSGALG00000004143|UniProtKB=Q5ZLQ6	14-3-3 protein beta/alpha	ISS	91108808	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00057	Wnt signaling pathway	P01435	SWI/SNF	DROME|FlyBase=FBgn0011604|UniProtKB=Q24368	Chromatin-remodeling complex ATPase chain Iswi	ISS	11532957	PubMed	PTHR10799:SF879	CHROMATIN-REMODELING COMPLEX ATPASE CHAIN ISWI
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000007642|UniProtKB=Q0VC81	Adenosine receptor A3	ISS	11781138	PubMed	PTHR24246:SF2	ADENOSINE RECEPTOR A3
P02756	N-acetylglucosamine metabolism	P03043	N-acetylglucosamine-1-phosphate uridyltransferase	THEMA|EnsemblGenome=TM_1629|UniProtKB=Q9X1W4	Bifunctional protein GlmU	ISS			PTHR43584:SF3	BIFUNCTIONAL PROTEIN GLMU
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	ISS	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P00046	Oxidative stress response	P01131	MKP5	RAT|RGD=1359712|UniProtKB=A0A0G2K9N1	Protein Dusp13	ISS			PTHR10159:SF365	DUAL SPECIFICITY PROTEIN PHOSPHATASE 13 ISOFORM B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000007576|UniProtKB=H2QA92	Uncharacterized protein	ISS	12562507	PubMed	PTHR24229:SF20	SOMATOSTATIN RECEPTOR TYPE 5
P05916	Opioid prodynorphin pathway	P06002	G-protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	12488551	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00019	Endothelin signaling pathway	P00587	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	HUMAN|HGNC=18854|UniProtKB=Q8TEY5	Cyclic AMP-responsive element-binding protein 3-like protein 4	ISS	1354612	PubMed	PTHR22952:SF105	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 4
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IGI	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00034	Integrin signalling pathway	P00925	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00012	Cadherin signaling pathway	P00474	Wnt	BOVIN|Ensembl=ENSBTAG00000009217|UniProtKB=F1MEW8	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	RAT|RGD=1306821|UniProtKB=F1LNF0	Protein Myh14	ISS	89264452	PubMed	PTHR13140:SF462	MYOSIN-14
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05913	Enkephalin release	P05974	G-Protein (i)	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	IC	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05915	Opioid proenkephalin pathway	P05990	K+ channel	RAT|RGD=61997|UniProtKB=O54912	Potassium channel subfamily K member 3	ISS	11875121	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	SCHMA|EnsemblGenome=Smp_020170|UniProtKB=G4V8E3	Voltage-dependent calcium channel (Fragment)	ISS	14507926	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P02738	De novo purine biosynthesis	P02907	dADP kinase	CANLF|Ensembl=ENSCAFG00000015252|UniProtKB=F1PMF2	Uncharacterized protein	ISS			PTHR43109:SF2	NUCLEOSIDE DIPHOSPHATE KINASE 7
P00057	Wnt signaling pathway	P01471	alpha-catenin	MACMU|Ensembl=ENSMMUG00000000293|UniProtKB=F6YFG3	Uncharacterized protein	ISS	1768802	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00024	Glycolysis	P00679	Aldolase	MACMU|Ensembl=ENSMMUG00000000983|UniProtKB=F6SYL4	Fructose-bisphosphate aldolase	ISS	3391172	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=621516|UniProtKB=G3V6P8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	CANLF|Ensembl=ENSCAFG00000001738|UniProtKB=E2RDG9	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00029	Huntington disease	P00767	Pro-caspase 8	MACMU|Ensembl=ENSMMUG00000031296|UniProtKB=F7C587	Uncharacterized protein	ISS	11917123	PubMed	PTHR10454:SF162	CASPASE-8
P05918	p38 MAPK pathway	P06031	p38alpha	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00632	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	10395542	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	ORNAN|Ensembl=ENSOANG00000015652|UniProtKB=F7FY70	Uncharacterized protein	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00012	Cadherin signaling pathway	P00462	Casein kinase II	MONDO|Ensembl=ENSMODG00000014080|UniProtKB=F6R511	Uncharacterized protein (Fragment)	ISS	10806215	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00018	EGF receptor signaling pathway	P00559	MEK1-2	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	RAT|RGD=735151|UniProtKB=Q6U2D6	Chemokine (C-C motif) receptor 7	ISS	12133980	PubMed	PTHR10489:SF635	C-C CHEMOKINE RECEPTOR TYPE 7
P00029	Huntington disease	P00777	CBP	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	IDA	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IGI	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00049	Parkinson disease	P01211	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	20384797	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00629	PP2A	HUMAN|HGNC=9312|UniProtKB=Q14738	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	IPI	12110603	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00047	PDGF signaling pathway	P01153	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00007	Axon guidance mediated by semaphorins	P00340	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00018	EGF receptor signaling pathway	P00547	PP2A	TAKRU|Ensembl=ENSTRUG00000008018|UniProtKB=H2T5N4	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	RAT|RGD=620966|UniProtKB=Q62925	Mitogen-activated protein kinase kinase kinase 1	IGI	12049732	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IC	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00006	Apoptosis signaling pathway	P00260	AKT	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	ISS	7876156	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00962	ELK	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	IDA	11050086	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00025	Hedgehog signaling pathway	P00682	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00920	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	DANRE|ZFIN=ZDB-GENE-030616-53|UniProtKB=Q71E60	AMPA receptor subunit GluR3B	ISS	10331083	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00034	Integrin signalling pathway	P00941	Integrin alpha	PANTR|Ensembl=ENSPTRG00000012641|UniProtKB=H2R2A9	Uncharacterized protein	ISS	3487386	PubMed	PTHR23220:SF9	INTEGRIN ALPHA-6
P00006	Apoptosis signaling pathway	P00274	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BOVIN|Ensembl=ENSBTAG00000022671|UniProtKB=F1MZV4	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00739	AGS3	BOVIN|Ensembl=ENSBTAG00000017124|UniProtKB=E1BIX7	Uncharacterized protein	ISS	11121039	PubMed	PTHR10098:SF100	G-PROTEIN-SIGNALING MODULATOR 2
P00057	Wnt signaling pathway	P01449	Nemo-like Kinase	CIOIN|Ensembl=ENSCING00000005358|UniProtKB=Q4H358	Mitogen-activated protein kinase	ISS	10683140	PubMed	PTHR24055:SF344	MITOGEN-ACTIVATED PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00547	PP2A	CHICK|Ensembl=ENSGALG00000010273|UniProtKB=P48463	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	IGI	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	BOVIN|Ensembl=ENSBTAG00000004775|UniProtKB=F1MBY1	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00053	T cell activation	P01300	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P06664	Gonadotropin-releasing hormone receptor pathway	P06807	gnai	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	RCA	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00019	Endothelin signaling pathway	P00586	Gq	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00036	Interleukin signaling pathway	P00964	p90RSK	MACMU|Ensembl=ENSMMUG00000002134|UniProtKB=F6UNV6	Ribosomal protein S6 kinase	ISS	10480933	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00057	Wnt signaling pathway	P01465	Ggamma	PANTR|Ensembl=ENSPTRG00000006342|UniProtKB=H2Q8A8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04393	Ras Pathway	P04558	p38	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	IDA	10995439	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00015	Circadian clock system	G01503	per	BOVIN|Ensembl=ENSBTAG00000003889|UniProtKB=F1MDK3	Uncharacterized protein	ISS	12782655	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P04393	Ras Pathway	P04572	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00021	FGF signaling pathway	P00624	14-3-3	BOVIN|Ensembl=ENSBTAG00000005664|UniProtKB=P62261	14-3-3 protein epsilon	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00029	Huntington disease	P00805	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00274	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00056	VEGF signaling pathway	P01408	Akt/PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01284	JNK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01435	SWI/SNF	BOVIN|Ensembl=ENSBTAG00000001024|UniProtKB=E1B925	Uncharacterized protein	ISS	11532957	PubMed	PTHR12656:SF12	AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 1A
P02781	Threonine biosynthesis	P03189	Aspartate kinase	AQUAE|EnsemblGenome=aq_1152|UniProtKB=O67221	Aspartokinase	ISS			PTHR21499:SF3	ASPARTOKINASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00018	EGF receptor signaling pathway	P00547	PP2A	MACMU|Ensembl=ENSMMUG00000020819|UniProtKB=F7HSM1	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00907	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00020	FAS signaling pathway	P00609	FAF1	DROME|FlyBase=FBgn0034068|UniProtKB=Q7JUP3	Caspar, isoform A	ISS			PTHR23322:SF52	FAS-ASSOCIATED FACTOR 1
P00034	Integrin signalling pathway	P00914	Filamin	RAT|RGD=1560614|UniProtKB=C0JPT7	Filamin alpha	ISS	9722563	PubMed	PTHR43998:SF6	FILAMIN-A
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01189	PTEN	XENTR|Xenbase=XB-GENE-491433|UniProtKB=B1H2U0	Pten protein	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	CANLF|Ensembl=ENSCAFG00000009967|UniProtKB=F1PGZ2	Muscarinic acetylcholine receptor	ISS	12181435	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00015	Circadian clock system	G01504	bmal1	BOVIN|Ensembl=ENSBTAG00000013029|UniProtKB=E1BLF5	Uncharacterized protein	ISS	11163178	PubMed	PTHR23042:SF52	ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 1
P00021	FGF signaling pathway	P00639	Shc	MACMU|Ensembl=ENSMMUG00000020357|UniProtKB=F6W915	SHC-transforming protein 3	ISS	98175964	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	PANTR|Ensembl=ENSPTRG00000021282|UniProtKB=H2R051	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF4	REGULATOR OF G-PROTEIN SIGNALING 3
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000025373|UniProtKB=F6ZZG9	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04380	Cortocotropin releasing factor receptor signaling pathway	P04453	ACTH	RAT|RGD=3366|UniProtKB=P01194	Pro-opiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00004	Alzheimer disease-presenilin pathway	P00114	actin	XENTR|Xenbase=XB-GENE-491938|UniProtKB=Q6DIV8	Actin, alpha 1, skeletal muscle	ISS	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	IC	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00018	EGF receptor signaling pathway	P00562	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00025	Hedgehog signaling pathway	P00692	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	HUMAN|HGNC=19663|UniProtKB=Q9UBI6	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00034	Integrin signalling pathway	P00944	Actin	BOVIN|Ensembl=ENSBTAG00000006189|UniProtKB=P63258	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANAL|CGD=CAL0068551|UniProtKB=Q5AAR9	Phosphatidylinositol 3-kinase	ISS	20330542	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000002775|UniProtKB=H2RB55	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	BOVIN|Ensembl=ENSBTAG00000000042|UniProtKB=Q58DT4	Pyrroline-5-carboxylate reductase 1, mitochondrial	ISS			PTHR11645:SF6	PYRROLINE-5-CARBOXYLATE REDUCTASE 1, MITOCHONDRIAL
P00049	Parkinson disease	P01219	SAPK	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00021	FGF signaling pathway	P00629	PP2A	XENTR|Xenbase=XB-GENE-946380|UniProtKB=Q0D2F4	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform	ISS	9125135	PubMed	PTHR11871:SF1	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B BETA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04398	p53 pathway feedback loops 2	P04665	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04570	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01148	Grb2	MACMU|Ensembl=ENSMMUG00000005327|UniProtKB=F7GJG7	GRB2-related adapter protein	ISS	9741627	PubMed	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	MACMU|Ensembl=ENSMMUG00000010184|UniProtKB=F6SR09	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	STRPU|EnsemblGenome=SPU_012282|UniProtKB=W4Y969	Uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF369	ACTIN-42A
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	MOUSE|MGI=MGI=102891|UniProtKB=P51829	Adenylate cyclase type 7	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00633	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05913	Enkephalin release	P05972	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00558	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	IGI	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	IC	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	EMENI|EnsemblGenome=CADANIAG00006082|UniProtKB=P18819	NADP-specific glutamate dehydrogenase	ISS			PTHR43571:SF1	NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DROME|FlyBase=FBgn0011743|UniProtKB=P45891	Actin-like protein 53D	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00005	Angiogenesis	P00251	cPLA2	PANTR|Ensembl=ENSPTRG00000001787|UniProtKB=H2Q0T0	Phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00371	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00375	Calmodulin	DANRE|Ensembl=ENSDARG00000015050|UniProtKB=Q6PI52	Calmodulin	ISS	7514101	PubMed	PTHR23050:SF326	CALMODULIN
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000000712|UniProtKB=F6YS32	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF322	CADHERIN-6
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	ANOGA|EnsemblGenome=AGAP004233|UniProtKB=Q7QB20	AGAP004233-PA	ISS			PTHR11618:SF4	TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT
P00005	Angiogenesis	P00204	PLD	RAT|RGD=3349|UniProtKB=P70496	Phospholipase D1	ISS	9307024	PubMed	PTHR18896:SF57	PHOSPHOLIPASE D1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00057	Wnt signaling pathway	P01444	Wnt	ORNAN|Ensembl=ENSOANG00000011077|UniProtKB=F7FK62	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	CAEEL|WormBase=WBGene00004392|UniProtKB=P42170	Ribonucleoside-diphosphate reductase small chain	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04372	5-Hydroxytryptamine degredation	P04401	Monoamine Oxidase	HUMAN|HGNC=6834|UniProtKB=P27338	Amine oxidase [flavin-containing] B	ISS	8602220	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P00034	Integrin signalling pathway	P00911	B-Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00024	Glycolysis	P00678	Enolase	MACMU|Ensembl=ENSMMUG00000022947|UniProtKB=F6U6Q6	Uncharacterized protein	ISS	99439677	PubMed	PTHR11902:SF12	ALPHA-ENOLASE
P00045	Notch signaling pathway	P01119	NIct	BOVIN|Ensembl=ENSBTAG00000007909|UniProtKB=F1MPE9	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	IC	10704417	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00021	FGF signaling pathway	P00629	PP2A	IXOSC|EnsemblGenome=ISCW014549|UniProtKB=B7QGY5	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P06587	Nicotine pharmacodynamics pathway	P06606	ADCY2	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	DROME|FlyBase=FBgn0004623|UniProtKB=P29829	Guanine nucleotide-binding protein subunit beta-2	ISS	9754712	PubMed	PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00029	Huntington disease	G01531	BDNF	HUMAN|HGNC=1033|UniProtKB=P23560	Brain-derived neurotrophic factor	ISS	11408619	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	TAS	10571227	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00034	Integrin signalling pathway	P00912	Arp2/3	MOUSE|MGI=MGI=3648102|UniProtKB=E9Q2K4	Actin-related protein 2/3 complex subunit 5	IPI	12473693	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P02740	De novo pyrimidine ribonucleotides biosythesis	P02926	Aspartate carbamoyltransferase	AQUAE|EnsemblGenome=aq_409|UniProtKB=O66726	Aspartate carbamoyltransferase	ISS			PTHR11405:SF16	ASPARTATE CARBAMOYLTRANSFERASE, CHLOROPLASTIC
P06212	DPP-SCW signaling pathway	P06274	SAX	DROME|Gene=Dmel_CG1891|UniProtKB=A0A0B4K7J3	Receptor protein serine/threonine kinase	IDA	8134837	PubMed	PTHR23255:SF72	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00010	B cell activation	P00385	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	15470041	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	ECOLI|EcoGene=EG11002|UniProtKB=P0A884	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	CAEBR|Gene=CBG_05938|UniProtKB=H8WGV2	Protein CBR-ITR-1, isoform a	ISS	11007872	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	BOVIN|Ensembl=ENSBTAG00000018239|UniProtKB=A5D7F5	DnaJ homolog subfamily C member 27	ISS			PTHR24073:SF269	DNAJ HOMOLOG SUBFAMILY C MEMBER 27
P00022	General transcription by RNA polymerase I	P00657	TBP	DANRE|ZFIN=ZDB-GENE-040520-3|UniProtKB=Q1JPY4	TATA box-binding protein-like protein 2	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00056	VEGF signaling pathway	P01414	PLC-gamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00056	VEGF signaling pathway	P01407	Erk	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9836512	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	MOUSE|MGI=MGI=109482|UniProtKB=P97445	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	15699344	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	DROME|FlyBase=FBgn0030011|UniProtKB=Q9W3J1	Gbeta5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00019	Endothelin signaling pathway	P00590	IP3 R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00018	EGF receptor signaling pathway	P00556	PLCgamma	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00036	Interleukin signaling pathway	P00970	Interleukin	HUMAN|HGNC=6016|UniProtKB=P05113	Interleukin-5	IC			PTHR45421:SF1	INTERLEUKIN-5
P00019	Endothelin signaling pathway	P00591	PLCbeta	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IGI	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IGI	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04395	Vasopressin synthesis	P04589	Signal Peptidase	MACMU|Ensembl=ENSMMUG00000004408|UniProtKB=F7GUB4	Signal peptidase complex catalytic subunit SEC11	ISS	2092035	PubMed	PTHR10806:SF12	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11C
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00053	T cell activation	P01323	I kappa B	CHICK|Gene=NFKBIA|UniProtKB=Q91974	NF-kappa-B inhibitor alpha	IGI	14665694	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P02729	Ascorbate degradation	P02852	L-xylulose-5-phosphate-3-epimerase	BACTN|EnsemblGenome=BT_3946|UniProtKB=Q8A0S5	Ribulose-phosphate 3-epimerase	ISS			PTHR11749:SF3	RIBULOSE-PHOSPHATE 3-EPIMERASE
P00045	Notch signaling pathway	P01099	Notch	MOUSE|MGI=MGI=107471|UniProtKB=P31695	Neurogenic locus notch homolog protein 4	ISS	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P00021	FGF signaling pathway	P00636	FGFR1-4	CANLF|Ensembl=ENSCAFG00000014993|UniProtKB=F1P9Z7	Fibroblast growth factor receptor	ISS	14520460	PubMed	PTHR24416:SF505	FIBROBLAST GROWTH FACTOR RECEPTOR 3
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00057	Wnt signaling pathway	P01472	Histone deacetylase	DROME|FlyBase=FBgn0015805|UniProtKB=Q94517	Histone deacetylase Rpd3	IDA	10485845	PubMed	PTHR10625:SF171	HISTONE DEACETYLASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	ORNAN|Ensembl=ENSOANG00000013961|UniProtKB=F6VPY1	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05917	Opioid proopiomelanocortin pathway	P06006	beta-Endorphin	PANTR|Ensembl=ENSPTRG00000011721|UniProtKB=H2R8Y3	Uncharacterized protein	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00015	Circadian clock system	P00506	BMAL1	CHICK|Ensembl=ENSGALG00000005378|UniProtKB=Q9I8T7	Aryl hydrocarbon receptor nuclear translocator-like protein 1	ISS	11163178	PubMed	PTHR23042:SF52	ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 1
P00010	B cell activation	P00388	PLC gamma2	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00006	Apoptosis signaling pathway	P00260	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00629	PP2A	XENTR|Xenbase=XB-GENE-484003|UniProtKB=Q6P365	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00020	FAS signaling pathway	P00604	Pro-Caspase8	HUMAN|HGNC=1509|UniProtKB=Q14790	Caspase-8	ISS	11788820	PubMed	PTHR10454:SF162	CASPASE-8
P00029	Huntington disease	P00771	Sin3A	ARATH|TAIR=AT5G15020|UniProtKB=Q9LFQ3	Paired amphipathic helix protein Sin3-like 2	IDA	10441327	PubMed	PTHR12346:SF8	PAIRED AMPHIPATHIC HELIX PROTEIN SIN3-LIKE 1-RELATED
P00021	FGF signaling pathway	P00645	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00048	PI3 kinase pathway	P01199	Galpha	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00049	Parkinson disease	P01212	p38 MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MOUSE|MGI=MGI=87939|UniProtKB=P25962	Beta-3 adrenergic receptor	IDA	11943840	PubMed	PTHR24248:SF3	BETA-3 ADRENERGIC RECEPTOR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00006	Apoptosis signaling pathway	P00269	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00010	B cell activation	P00402	Jnk	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P06959	CCKR signaling map	G07269	REG1A	HUMAN|HGNC=9951|UniProtKB=P05451	Lithostathine-1-alpha	RCA	15109306	PubMed	PTHR43993:SF7	LITHOSTATHINE-1-ALPHA
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05730	Endogenous cannabinoid signaling	P05746	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01192	p110	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	DANRE|ZFIN=ZDB-GENE-000330-9|UniProtKB=Q90ZE4	Presenilin-2	IDA	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	ORYSJ|EnsemblGenome=OS02G0778400|UniProtKB=Q6K7H2	UMP-CMP kinase 4	ISS			PTHR23359:SF107	UMP-CMP KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	HUMAN|HGNC=6267|UniProtKB=P48051	G protein-activated inward rectifier potassium channel 2	IDA	12374786	PubMed	PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P00053	T cell activation	P01306	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	RAT|RGD=621487|UniProtKB=F1LNY6	Protein Taf2	ISS			PTHR15137:SF9	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2
P04395	Vasopressin synthesis	P04599	Amidating Enzyme	DROME|FlyBase=FBgn0262728|UniProtKB=Q9W1L5	Peptidyl-alpha-hydroxyglycine alpha-amidating lyase 2	IC	3153462	PubMed	PTHR10680:SF23	PEPTIDYL-ALPHA-HYDROXYGLYCINE ALPHA-AMIDATING LYASE 2
P00049	Parkinson disease	P01236	Casein kinase II	DAPPU|EnsemblGenome=DAPPUDRAFT_305830|UniProtKB=E9GTE8	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00059	p53 pathway	G01568	KILLER/DR5	PANTR|Ensembl=ENSPTRG00000020074|UniProtKB=H2QVW1	Tumor necrosis factor receptor superfamily, member 10a	ISS	11498783	PubMed	PTHR23097:SF179	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10A
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P06587	Nicotine pharmacodynamics pathway	P06602	PPP1CA	TRIAD|EnsemblGenome=TriadG30170|UniProtKB=B3S6H7	Serine/threonine-protein phosphatase	ISS	10433257	PubMed	PTHR11668:SF402	SERINE/THREONINE-PROTEIN PHOSPHATASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00384	p38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04398	p53 pathway feedback loops 2	P04665	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01236	Casein kinase II	DANRE|ZFIN=ZDB-GENE-040625-181|UniProtKB=Q6IQV0	Uncharacterized protein	ISS	10617630	PubMed	PTHR24054:SF28	CASEIN KINASE 2 ALPHA 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02918	dUTP pyrophosphatase	AQUAE|EnsemblGenome=aq_220|UniProtKB=O66592	Deoxyuridine 5'-triphosphate nucleotidohydrolase	ISS			PTHR11241:SF0	BCDNA.LD08534
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=3233|UniProtKB=P33533	Delta-type opioid receptor	IDA	11259487	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	CANLF|Ensembl=ENSCAFG00000004930|UniProtKB=E2RFB5	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	BOVIN|Ensembl=ENSBTAG00000018445|UniProtKB=E1BK87	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00830	Lipoxygenase	HUMAN|HGNC=436|UniProtKB=P20292	Arachidonate 5-lipoxygenase-activating protein	ISS	11937571	PubMed	PTHR10250:SF2	ARACHIDONATE 5-LIPOXYGENASE-ACTIVATING PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MACMU|Ensembl=ENSMMUG00000007486|UniProtKB=F6QL95	Frizzled-3	ISS	11212302	PubMed	PTHR11309:SF22	FRIZZLED-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00056	VEGF signaling pathway	P01423	p38MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00559	MEK1-2	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	IC	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04393	Ras Pathway	P04542	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	TAKRU|Ensembl=ENSTRUG00000010799|UniProtKB=H2TRF5	Uncharacterized protein	ISS			PTHR10540:SF7	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00402	Jnk	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IDA	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00624	14-3-3	RAT|RGD=62000|UniProtKB=P62260	14-3-3 protein epsilon	ISS	9450960	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	XENTR|Xenbase=XB-GENE-480347|UniProtKB=Q6P640	Actin, alpha cardiac muscle 1	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00021	FGF signaling pathway	P00625	MKK3,6	RAT|RGD=1306620|UniProtKB=B1H230	Map2k3 protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00029	Huntington disease	P00783	Rab8	HUMAN|HGNC=7007|UniProtKB=P61006	Ras-related protein Rab-8A	RCA			PTHR24073:SF635	RAS-RELATED PROTEIN RAB-8A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	PANTR|Ensembl=ENSPTRG00000014725|UniProtKB=H2QM91	Uncharacterized protein	ISS	12009564	PubMed	PTHR10489:SF608	C-C CHEMOKINE RECEPTOR TYPE 4
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00010	B cell activation	P00371	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	BOVIN|Ensembl=ENSBTAG00000009065|UniProtKB=F1MXH6	Uncharacterized protein	ISS	8974401	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00006	Apoptosis signaling pathway	P00260	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04398	p53 pathway feedback loops 2	P04657	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	IDA	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P06587	Nicotine pharmacodynamics pathway	P06602	PPP1CA	BOVIN|Ensembl=ENSBTAG00000011198|UniProtKB=P61287	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	ISS	8392016	PubMed	PTHR11668:SF204	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-GAMMA CATALYTIC SUBUNIT
P00038	JAK/STAT signaling pathway	P01034	Jak	PANTR|Ensembl=ENSPTRG00000020744|UniProtKB=H2QWZ4	Tyrosine-protein kinase	ISS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CHICK|Ensembl=ENSGALG00000004083|UniProtKB=Q90855	AMPA receptor GluR1/A	ISS	12941441	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00036	Interleukin signaling pathway	P00973	PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	PANTR|Ensembl=ENSPTRG00000005793|UniProtKB=H2REV2	Uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF139	CASEIN KINASE I ISOFORM ALPHA-LIKE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00009	Axon guidance mediated by netrin	P00363	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01284	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00565	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06747	ActRII	MOUSE|MGI=MGI=102806|UniProtKB=P27038	Activin receptor type-2A	RCA	11252892	PubMed	PTHR23255:SF64	ACTIVIN RECEPTOR TYPE-2A
P00018	EGF receptor signaling pathway	P00558	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00048	PI3 kinase pathway	P01185	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00005	Angiogenesis	P00209	FAK	MOUSE|MGI=MGI=95481|UniProtKB=P34152	Focal adhesion kinase 1	ISS	9182576	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00047	PDGF signaling pathway	P01154	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00036	Interleukin signaling pathway	P00990	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Ensembl=ENSCAFG00000001738|UniProtKB=E2RDG9	Uncharacterized protein	ISS	11431030	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00057	Wnt signaling pathway	P01443	Phospholipase C	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	HUMAN|HGNC=1403|UniProtKB=P54284	Voltage-dependent L-type calcium channel subunit beta-3	IC			PTHR11824:SF8	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00006	Apoptosis signaling pathway	P00274	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	TETTS|EnsemblGenome=TTHERM_00630500|UniProtKB=Q241P0	Calmodulin 1	ISS	7514101	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	MACMU|Ensembl=ENSMMUG00000016675|UniProtKB=F6VTB5	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00025	Hedgehog signaling pathway	P00682	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00021	FGF signaling pathway	P00627	ERK1-2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00586	Gq	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	DROME|FlyBase=FBgn0030011|UniProtKB=Q9W3J1	Gbeta5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00029	Huntington disease	P00778	NMDA receptor	PANTR|Ensembl=ENSPTRG00000023608|UniProtKB=H2QZZ2	Uncharacterized protein	ISS	14698601	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	RCA	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CANLF|Ensembl=ENSCAFG00000004381|UniProtKB=J9JH96	Uncharacterized protein	ISS	7476890	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00054	Toll receptor signaling pathway	P01364	TPL2	ORNAN|Ensembl=ENSOANG00000006044|UniProtKB=F6QKJ0	Uncharacterized protein	ISS	92019818	PubMed	PTHR24361:SF94	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 8
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MACMU|Ensembl=ENSMMUG00000000223|UniProtKB=F6XHK8	Uncharacterized protein	ISS	11701344	PubMed	PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P00057	Wnt signaling pathway	P01428	Frizzled	MOUSE|MGI=MGI=108570|UniProtKB=Q61090	Frizzled-7	IDA	8717036	PubMed	PTHR11309:SF31	FRIZZLED-7
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04398	p53 pathway feedback loops 2	G04714	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00019	Endothelin signaling pathway	P00570	PKA	DICDI|dictyBase=DDB_G0279413|UniProtKB=P05987	cAMP-dependent protein kinase regulatory subunit	IGI	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00029	Huntington disease	P00786	ARF	ARATH|TAIR=AT1G10630|UniProtKB=Q6ID97	ADP-ribosylation factor A1F	IPI	11752622	PubMed	PTHR11711:SF210	ADP-RIBOSYLATION FACTOR 2-A-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	RAT|RGD=71017|UniProtKB=Q9QZH0	Frizzled-4	TAS	11212302	PubMed	PTHR11309:SF23	FRIZZLED-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	BOVIN|Ensembl=ENSBTAG00000005464|UniProtKB=E1B9K3	Uncharacterized protein	ISS	92409599	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	XENTR|Xenbase=XB-GENE-490883|UniProtKB=Q6NVA9	Actin, cytoplasmic 1	ISS	11889139	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01419	Ets	MONDO|Ensembl=ENSMODG00000004730|UniProtKB=F6Y1Z2	Uncharacterized protein	ISS	15699632	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00049	Parkinson disease	P01219	SAPK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	NAS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00048	PI3 kinase pathway	P01188	Gbetagamma	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00021	FGF signaling pathway	P00642	MEK1-2	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04393	Ras Pathway	P04559	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	PANTR|Ensembl=ENSPTRG00000024326|UniProtKB=H2R231	Uncharacterized protein	ISS	12566458	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=7578|UniProtKB=P13535	Myosin-8	IC	89264452	PubMed	PTHR13140:SF368	MYOSIN-8
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00269	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00048	PI3 kinase pathway	P01199	Galpha	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	IC	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05730	Endogenous cannabinoid signaling	P05746	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00006	Apoptosis signaling pathway	P00321	HSP70	ORYSJ|EnsemblGenome=OS01G0840100|UniProtKB=Q943K7	70 kDa heat shock protein	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00057	Wnt signaling pathway	P01456	beta-arrestin	CAEEL|WormBase=WBGene00000195|UniProtKB=P51485	Probable beta-arrestin	IDA	11742073	PubMed	PTHR11792:SF17	KURTZ ARRESTIN
P00020	FAS signaling pathway	P00608	Pro-Caspase3	DANRE|ZFIN=ZDB-GENE-011210-1|UniProtKB=B8JK21	Uncharacterized protein	IGI	11675509	PubMed	PTHR10454:SF198	CASPASE-3
P00048	PI3 kinase pathway	G01543	IGFBP1	MOUSE|MGI=MGI=96436|UniProtKB=P47876	Insulin-like growth factor-binding protein 1	ISS			PTHR11551:SF6	INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 1
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MOUSE|MGI=MGI=108450|UniProtKB=P51830	Adenylate cyclase type 9	IDA	2491850	PubMed	PTHR11920:SF319	ADENYLATE CYCLASE TYPE 9
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	METAC|EnsemblGenome=MA_4331|UniProtKB=Q8TI26	TATA-box-binding protein 1	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	YEAST|SGD=S000001855|UniProtKB=P60010	Actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00019	Endothelin signaling pathway	P00570	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	IDA	2372396	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P02731	Biotin biosynthesis	P02856	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	MYCTU|EnsemblGenome=Rv1568|UniProtKB=P9WQ81	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	ISS			PTHR42684:SF3	ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	IDA	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00629	PP2A	ORYSJ|EnsemblGenome=OS09G0249700|UniProtKB=Q6K4K9	Os09g0249700 protein	ISS			PTHR10648:SF4	PROTEIN PHOSPHATASE 2  FORMERLY 2A , REGULATORY SUBUNIT A, BETA ISOFORM
P05915	Opioid proenkephalin pathway	P05994	G-protein	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00012	Cadherin signaling pathway	P00465	TCF/LEF	BOVIN|Ensembl=ENSBTAG00000006844|UniProtKB=E1BJ93	Uncharacterized protein	ISS	11266476	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	XENTR|Xenbase=XB-GENE-1011906|UniProtKB=F6XPD5	Uncharacterized protein (Fragment)	ISS			PTHR11824:SF8	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-3
P00034	Integrin signalling pathway	P00907	ERK	PANTR|Ensembl=ENSPTRG00000020224|UniProtKB=H2Q9G3	Mitogen-activated protein kinase 6	ISS	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00046	Oxidative stress response	P01125	Stat1	HUMAN|HGNC=11362|UniProtKB=P42224	Signal transducer and activator of transcription 1-alpha/beta	TAS	14755057	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00011	Blood coagulation	P00439	Prekallikrein	RAT|RGD=67382|UniProtKB=P14272	Plasma kallikrein	ISS	6981134	gi	PTHR44459:SF2	PLASMA KALLIKREIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	IDA	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00322	Cytochrome C	CHLRE|EnsemblGenome=CHLREDRAFT_176233|UniProtKB=A8J5T0	Mitochondrial cytochrome c	ISS	2853233	PubMed	PTHR11961:SF12	CYTOCHROME C
P00005	Angiogenesis	P00189	Fzd	MACMU|Ensembl=ENSMMUG00000013656|UniProtKB=F7GI70	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF126	FRIZZLED-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00308	Mcl1	MOUSE|MGI=MGI=101769|UniProtKB=P97287	Induced myeloid leukemia cell differentiation protein Mcl-1 homolog	ISS			PTHR11256:SF46	INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN MCL-1
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06798	PKCe/theta	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00006	Apoptosis signaling pathway	P00292	IkappaB	MOUSE|MGI=MGI=104741|UniProtKB=Q9Z1E3	NF-kappa-B inhibitor alpha	ISS	12637573	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00055	Transcription regulation by bZIP transcription factor	P01395	TFIIE	MOUSE|MGI=MGI=1921447|UniProtKB=Q9D0D5	General transcription factor IIE subunit 1	ISS	92065982	PubMed	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P05734	Synaptic vesicle trafficking	P05774	NSF	XENTR|Ensembl=ENSXETG00000031364|UniProtKB=F6PIV9	Uncharacterized protein	ISS	11348590	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00019	Endothelin signaling pathway	P00577	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00715	AGS3	BOVIN|Ensembl=ENSBTAG00000017124|UniProtKB=E1BIX7	Uncharacterized protein	ISS	11121039	PubMed	PTHR10098:SF100	G-PROTEIN-SIGNALING MODULATOR 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	DROME|FlyBase=FBgn0022709|UniProtKB=Q8IQG9	Adenylate kinase 1, isoform B	ISS			PTHR23359:SF70	ADENYLATE KINASE 1, ISOFORM B
P05730	Endogenous cannabinoid signaling	P05746	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	CHICK|Ensembl=ENSGALG00000013224|UniProtKB=F1NMA4	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00053	T cell activation	P01300	ERK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00056	VEGF signaling pathway	P01414	PLC-gamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00019	Endothelin signaling pathway	P00585	ECE1-3	RAT|RGD=1303039|UniProtKB=D4A4U1	Protein Ece2	RCA			PTHR11733:SF127	ENDOTHELIN-CONVERTING ENZYME 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	IC	10395542	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Gene=OPRM1|UniProtKB=P79350	Mu-type opioid receptor	IDA	11259487	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MOUSE|MGI=MGI=1927498|UniProtKB=Q99PG4	Regulator of G-protein signaling 18	IDA	8756726	PubMed	PTHR10845:SF155	REGULATOR OF G-PROTEIN SIGNALING 18
P00005	Angiogenesis	P00226	Delta/Serrate	XENTR|Xenbase=XB-GENE-968497|UniProtKB=F7CZA9	Delta-like protein	ISS			PTHR24044:SF308	DELTA-LIKE PROTEIN 3
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	BOVIN|Ensembl=ENSBTAG00000016420|UniProtKB=Q0VCX4	Catenin beta-1	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00056	VEGF signaling pathway	P01417	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01219	SAPK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	IDA	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	MOUSE|MGI=MGI=94890|UniProtKB=P00375	Dihydrofolate reductase	ISS			PTHR22778:SF16	DIHYDROFOLATE REDUCTASE
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	RAT|RGD=61800|UniProtKB=P14842	5-hydroxytryptamine receptor 2A	ISS	11859080	PubMed	PTHR24247:SF30	5-HYDROXYTRYPTAMINE RECEPTOR 2A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	HUMAN|HGNC=8591|UniProtKB=Q13177	Serine/threonine-protein kinase PAK 2	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00758	Phosducin	HUMAN|HGNC=8759|UniProtKB=P20941	Phosducin	IDA	10360181	PubMed	PTHR21148:SF17	PHOSDUCIN
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BOVIN|Ensembl=ENSBTAG00000006495|UniProtKB=P11017	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00025	Hedgehog signaling pathway	P00682	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04556	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00017	DNA replication	P00527	Histones	BOVIN|Ensembl=ENSBTAG00000024561|UniProtKB=Q5E9F8	Histone H3.3	ISS	20448842	PubMed	PTHR11426:SF179	HISTONE H3.3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00029	Huntington disease	P00807	Actin	SCHMA|EnsemblGenome=Smp_183710|UniProtKB=G4VLW1	Putative actin	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	MACMU|Gene=HTR2A|UniProtKB=P50128	5-hydroxytryptamine receptor 2A	ISS	12181435	PubMed	PTHR24247:SF30	5-HYDROXYTRYPTAMINE RECEPTOR 2A
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00053	T cell activation	P01332	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IDA	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01150	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00057	Wnt signaling pathway	P01465	Ggamma	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00053	T cell activation	P01312	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00034	Integrin signalling pathway	P00924	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IPI	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01330	IKK	PANTR|Ensembl=ENSPTRG00000020202|UniProtKB=H2QW34	Uncharacterized protein	ISS	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00049	Parkinson disease	P01211	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00642	MEK1-2	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01072	CHT1	RHOBA|EnsemblGenome=RB8472|UniProtKB=Q7UFM6	High affinity choline transporter	IC	12675135	PubMed	PTHR43291:SF6	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00769	N-Wasp	MACMU|Ensembl=ENSMMUG00000011544|UniProtKB=F7BU81	Neural Wiskott-Aldrich syndrome protein	ISS	12932731	PubMed	PTHR23202:SF39	NEURAL WISKOTT-ALDRICH SYNDROME PROTEIN
P00048	PI3 kinase pathway	P01179	PKB	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00470	F-actin	BOVIN|Ensembl=ENSBTAG00000006189|UniProtKB=P63258	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00034	Integrin signalling pathway	P00932	FAK	PANTR|Ensembl=ENSPTRG00000020104|UniProtKB=H2QVX8	PTK2B protein tyrosine kinase 2 beta	ISS	10753828	PubMed	PTHR24418:SF94	PROTEIN-TYROSINE KINASE 2-BETA
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CHICK|Ensembl=ENSGALG00000017178|UniProtKB=F1N982	Uncharacterized protein	ISS	12497607	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00005	Angiogenesis	P00209	FAK	BOVIN|Ensembl=ENSBTAG00000009578|UniProtKB=G3N3B7	Uncharacterized protein	ISS	12640026	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00038	JAK/STAT signaling pathway	P01027	STAT	RAT|RGD=3772|UniProtKB=P52631	Signal transducer and activator of transcription 3	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00030	Hypoxia response via HIF activation	P00823	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BOVIN|Ensembl=ENSBTAG00000014291|UniProtKB=A6H6X8	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00951	Jnk	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00047	PDGF signaling pathway	P01165	SRF	PANTR|Ensembl=ENSPTRG00000018189|UniProtKB=H2QT21	Uncharacterized protein	ISS	8660892	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	ENTHI|EnsemblGenome=EHI_110810|UniProtKB=C4LUC7	Unconventional myosin IB	IC			PTHR13140:SF674	MYOSIN IB HEAVY CHAIN-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MONDO|Ensembl=ENSMODG00000018204|UniProtKB=F6PGX6	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	CANLF|Ensembl=ENSCAFG00000010856|UniProtKB=F1PX57	Uncharacterized protein	ISS			PTHR10943:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	RAT|RGD=2157|UniProtKB=P29067	Beta-arrestin-2	ISS	11742073	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	HUMAN|HGNC=4586|UniProtKB=Q13224	Glutamate receptor ionotropic, NMDA 2B	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00036	Interleukin signaling pathway	P00995	c-Myc	RAT|RGD=3130|UniProtKB=P09416	Myc proto-oncogene protein	ISS	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	IC	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	RCA	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00053	T cell activation	P01297	MEKK	RAT|RGD=620966|UniProtKB=Q62925	Mitogen-activated protein kinase kinase kinase 1	RCA	12168099	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01322	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000012293|UniProtKB=F7DRD8	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF290	CADHERIN-10
P00021	FGF signaling pathway	P00629	PP2A	NEUCR|EnsemblGenome=EFNCRG00000003366|UniProtKB=Q7S7P2	Serine/threonine protein phosphatase 2A	ISS			PTHR10257:SF3	PP2A-B', ISOFORM B
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00319	TRADD	HUMAN|HGNC=12030|UniProtKB=Q15628	Tumor necrosis factor receptor type 1-associated DEATH domain protein	IDA	10892748	PubMed	PTHR14913:SF0	TUMOR NECROSIS FACTOR RECEPTOR TYPE 1-ASSOCIATED DEATH DOMAIN PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00111	C99	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00005	Angiogenesis	P00223	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	RAT|RGD=1311985|UniProtKB=B2GV73	Actin-related protein 2/3 complex subunit 3	ISS	12473693	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00018	EGF receptor signaling pathway	P00539	14-3-3	HUMAN|HGNC=12851|UniProtKB=P62258	14-3-3 protein epsilon	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00059	p53 pathway	G04696	Siah	RAT|RGD=620449|UniProtKB=Q920M9	E3 ubiquitin-protein ligase SIAH1	ISS	11389839	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	CANLF|Ensembl=ENSCAFG00000004956|UniProtKB=E2REH3	Uncharacterized protein	ISS	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P02783	Tryptophan biosynthesis	P03209	Anthranilate phosphoribosyl transferase	GLOVI|Gene=BAC89500|UniProtKB=Q7NKB9	Glr1559 protein	ISS			PTHR43285:SF3	SUBFAMILY NOT NAMED
P06959	CCKR signaling map	G07295	VMAT2	HUMAN|HGNC=10935|UniProtKB=Q05940	Synaptic vesicular amine transporter	RCA	11459816	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P02741	Flavin biosynthesis	P02935	GTP cyclohydrolase	BACTN|EnsemblGenome=BT_2416|UniProtKB=Q8A528	Riboflavin biosynthesis protein RibBA	ISS			PTHR21327:SF32	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00270	Bcl-2	PANTR|Ensembl=ENSPTRG00000010079|UniProtKB=H2QEM8	B-cell CLL/lymphoma 2	ISS	11323415	PubMed	PTHR11256:SF11	APOPTOSIS REGULATOR BCL-2
P00019	Endothelin signaling pathway	P00570	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	ISS	91298951	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00965	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IC	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05913	Enkephalin release	G06046	preproenkephalin mRNA	PANTR|Ensembl=ENSPTRG00000020270|UniProtKB=H2QW70	Proenkephalin	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00012	Cadherin signaling pathway	P00474	Wnt	RAT|RGD=1309574|UniProtKB=D3ZFS0	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF84	PROTEIN WNT-9B
P02749	Leucine biosynthesis	P03002	Isopropylmalate isomerase	BACSU|EnsemblGenome=BSU28260|UniProtKB=P80858	3-isopropylmalate dehydratase large subunit	ISS			PTHR43822:SF2	HOMOACONITASE, MITOCHONDRIAL
P00015	Circadian clock system	P00505	Cry	XENTR|Xenbase=XB-GENE-946007|UniProtKB=F6X865	Uncharacterized protein	ISS			PTHR11455:SF16	CRYPTOCHROME-1
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	RAT|RGD=1307535|UniProtKB=G3V928	Protein Lrp1	ISS	11907044	PubMed	PTHR44025:SF2	PROLOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1
P04393	Ras Pathway	P04556	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04392	P53 pathway feedback loops 1	G04685	p73DeltaN	HUMAN|HGNC=15979|UniProtKB=Q9H3D4	Tumor protein 63	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00201	FVIIa	PANTR|Gene=F7|UniProtKB=Q2F9P2	Coagulation factor VII	ISS	11487022	PubMed	PTHR44064:SF1	COAGULATION FACTOR VII
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MONDO|Ensembl=ENSMODG00000004422|UniProtKB=F6SCX2	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF344	MYOSIN-7
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IDA	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8971|UniProtKB=O00443	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00005	Angiogenesis	P00206	Wnt	HUMAN|HGNC=12780|UniProtKB=P09544	Protein Wnt-2	ISS	8717036	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IPI	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06587	Nicotine pharmacodynamics pathway	P06606	ADCY2	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00018	EGF receptor signaling pathway	P00545	JNK1-3	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IGI	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00036	Interleukin signaling pathway	P00996	STAT	MACMU|Ensembl=ENSMMUG00000010705|UniProtKB=F7G8V4	Signal transducer and activator of transcription	ISS	10835485	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	8170357	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IDA	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	G01511	SPRY	MACMU|Ensembl=ENSMMUG00000001848|UniProtKB=F7GQV4	Protein sprouty homolog 1	ISS	98117253	PubMed	PTHR12365:SF10	PROTEIN SPROUTY HOMOLOG 1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PHYPA|Gene=PHYPADRAFT_107830|UniProtKB=A9TBG2	Actin 7	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00053	T cell activation	P01322	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	IGI	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00029	Huntington disease	P00807	Actin	TRIVA|Gene=TVAG_054030|UniProtKB=A2G1K5	Actin	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00036	Interleukin signaling pathway	P00987	SRF	HUMAN|HGNC=11291|UniProtKB=P11831	Serum response factor	IC	8660892	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CHICK|Ensembl=ENSGALG00000011809|UniProtKB=F1NMB0	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	IDA	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01142	p90RSK	BOVIN|Ensembl=ENSBTAG00000010906|UniProtKB=E1BN61	Ribosomal protein S6 kinase	ISS	9687510	PubMed	PTHR24351:SF115	RIBOSOMAL PROTEIN S6 KINASE ALPHA-5
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IDA	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00260	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01143	ERK	RAT|RGD=1311192|UniProtKB=A0A0G2K3R1	Protein Map3k4	ISS			PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P02746	Heme biosynthesis	P02981	Glutamate-1-semialdehyde aminotransferase	STRCO|EnsemblGenome=CAC08376|UniProtKB=Q9F2S0	Glutamate-1-semialdehyde 2,1-aminomutase	ISS			PTHR43713:SF3	GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE
P00057	Wnt signaling pathway	P01457	GBeta	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01438	PP2A	PANTR|Ensembl=ENSPTRG00000006426|UniProtKB=H2Q8F8	Protein phosphatase 2, regulatory subunit B', epsilon isoform	ISS	10092233	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF31	SUBFAMILY NOT NAMED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	RCA	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	PANTR|Gene=DVL1|UniProtKB=Q5IS48	Segment polarity protein dishevelled homolog DVL-1	ISS	11212302	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P00019	Endothelin signaling pathway	P00586	Gq	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	RCA	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00018	EGF receptor signaling pathway	P00552	Ras	MOUSE|MGI=MGI=1914172|UniProtKB=P62071	Ras-related protein R-Ras2	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	HUMAN|HGNC=5183|UniProtKB=P25021	Histamine H2 receptor	IDA	8817552	PubMed	PTHR43893:SF5	HISTAMINE H2 RECEPTOR
P00054	Toll receptor signaling pathway	P01356	ERK2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00046	Oxidative stress response	P01132	c-jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00030	Hypoxia response via HIF activation	P00819	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000016595|UniProtKB=F6ZDB2	Uncharacterized protein	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01300	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04574	PLD	HUMAN|HGNC=9068|UniProtKB=O14939	Phospholipase D2	IDA	15030398	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04585	TRH	HUMAN|HGNC=12298|UniProtKB=P20396	Pro-thyrotropin-releasing hormone	ISS	2126343	PubMed	PTHR17530:SF2	PRO-THYROTROPIN-RELEASING HORMONE
P00048	PI3 kinase pathway	P01192	p110	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05918	p38 MAPK pathway	P06031	p38alpha	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00017	DNA replication	P00527	Histones	ARATH|TAIR=AT4G40030|UniProtKB=P59169	Histone H3.3	ISS	12413958	PubMed	PTHR11426:SF178	HISTONE H3-LIKE 1-RELATED
P00036	Interleukin signaling pathway	P00981	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	TAS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01453	Ebi	BOVIN|Ensembl=ENSBTAG00000021910|UniProtKB=F1MFJ6	Uncharacterized protein	ISS	11389839	PubMed	PTHR22846:SF40	F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN TBL1XR1
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00018	EGF receptor signaling pathway	G01511	SPRY	BOVIN|Gene=SPRY1|UniProtKB=A5D992	Protein sprouty homolog 1	ISS	98117253	PubMed	PTHR12365:SF10	PROTEIN SPROUTY HOMOLOG 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Gene=GRIK4|UniProtKB=Q5IS46	Glutamate receptor ionotropic, kainate 4	ISS	1648176	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	SCHPO|PomBase=SPBC32H8.07|UniProtKB=Q10282	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PANTR|Ensembl=ENSPTRG00000009762|UniProtKB=H2QE24	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00053	T cell activation	P01300	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	CANLF|Ensembl=ENSCAFG00000005945|UniProtKB=E2R8P1	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00053	T cell activation	P01300	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01438	PP2A	BOVIN|Ensembl=ENSBTAG00000000754|UniProtKB=A2VDZ0	Protein phosphatase 2, regulatory subunit B', alpha isoform	ISS	12110603	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	92020947	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00059	p53 pathway	P01480	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00049	Parkinson disease	P01227	20S proteasome	ANOGA|EnsemblGenome=AGAP011444|UniProtKB=Q7Q320	Proteasome subunit beta type	TAS	12859888	PubMed	PTHR11599:SF5	PROTEASOME SUBUNIT BETA TYPE-4
P02723	Adenine and hypoxanthine salvage pathway	P02809	Xanthine dehydrogenase	PSEAE|EnsemblGenome=PA1523|UniProtKB=Q9I3J0	Xanthine dehydrogenase	ISS			PTHR11908:SF100	XANTHINE DEHYDROGENASE
P05913	Enkephalin release	P05977	G-Protein (s)	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00005	Angiogenesis	P00208	MEKK1	MACMU|Ensembl=ENSMMUG00000012387|UniProtKB=F7EB20	Uncharacterized protein	ISS	8643568	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00021	FGF signaling pathway	P00633	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P00021	FGF signaling pathway	P00632	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P06664	Gonadotropin-releasing hormone receptor pathway	P06792	MISRII	MOUSE|MGI=MGI=105062|UniProtKB=Q8K592	Anti-Muellerian hormone type-2 receptor	RCA	9395284	PubMed	PTHR23255:SF49	ANTI-MUELLERIAN HORMONE TYPE-2 RECEPTOR
P00038	JAK/STAT signaling pathway	P01029	Serine kinase	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	ISS			PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MACMU|Gene=CHRM1|UniProtKB=P56489	Muscarinic acetylcholine receptor M1	IDA	10069496	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00009	Axon guidance mediated by netrin	P00363	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Ensembl=ENSGALG00000009621|UniProtKB=P60706	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MOUSE|MGI=MGI=894644|UniProtKB=Q8CC27	Voltage-dependent L-type calcium channel subunit beta-2	IC	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01080	AChE	BRAFL|Gene=BRAFLDRAFT_116869|UniProtKB=C3ZD75	Carboxylic ester hydrolase	ISS	87080761	PubMed	PTHR11559:SF356	ACETYLCHOLINESTERASE
P00034	Integrin signalling pathway	P00937	Vinculin	RAT|RGD=1311217|UniProtKB=P85972	Vinculin	ISS	14702644	PubMed	PTHR18914:SF1	VINCULIN
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	CHICK|Ensembl=ENSGALG00000001334|UniProtKB=F1NLV4	Uncharacterized protein	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00054	Toll receptor signaling pathway	P01356	ERK2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ORYSJ|EnsemblGenome=OS11G0163100|UniProtKB=Q67G20	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00852	PYK2	BOVIN|Ensembl=ENSBTAG00000005958|UniProtKB=F1N0Z0	Uncharacterized protein	ISS	12640026	PubMed	PTHR24418:SF94	PROTEIN-TYROSINE KINASE 2-BETA
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	IGI	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	STRCO|EnsemblGenome=CAB90845|UniProtKB=P15106	Glutamine synthetase	ISS			PTHR43407:SF1	LENGSIN
P00023	General transcription regulation	P00664	TFIIH complex	NEUCR|EnsemblGenome=EFNCRG00000006577|UniProtKB=Q9P5N7	Putative RNA polymerase II transcription factor B subunit 1	ISS			PTHR12856:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	IC	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00005	Angiogenesis	P00217	STAT3	CHICK|Ensembl=ENSGALG00000003267|UniProtKB=Q6DV79	Signal transducer and activator of transcription 3	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00001	Adrenaline and noradrenaline biosynthesis	P00071	VAT1	MACMU|Ensembl=ENSMMUG00000019999|UniProtKB=F7FNE2	Uncharacterized protein	ISS	12135927	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00892	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	12748278	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00049	Parkinson disease	P01219	SAPK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	NAS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00048	PI3 kinase pathway	P01192	p110	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MONDO|Ensembl=ENSMODG00000018204|UniProtKB=F6PGX6	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P02738	De novo purine biosynthesis	P02902	ADP reductase	DANRE|ZFIN=ZDB-GENE-990415-247|UniProtKB=P79732	Ribonucleoside-diphosphate reductase large subunit	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00052	TGF-beta signaling pathway	P01275	P38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	TAS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DANRE|ZFIN=ZDB-GENE-040426-1489|UniProtKB=Q6PHV0	Syntaxin 3A	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00036	Interleukin signaling pathway	P00981	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04398	p53 pathway feedback loops 2	P04665	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02724	Alanine biosynthesis	P02815	Branched chain amino acid aminotransferase	CAEEL|WormBase=WBGene00012855|UniProtKB=Q9XXD8	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF28	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00023	General transcription regulation	P00668	TFIIB	NEUCR|EnsemblGenome=EFNCRG00000005137|UniProtKB=Q7RY40	Uncharacterized protein	ISS	180660	OMIM	PTHR11618:SF4	TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT
P00060	Ubiquitin proteasome pathway	P01491	E2	CANLF|Ensembl=ENSCAFG00000005774|UniProtKB=E2QXE6	Uncharacterized protein	ISS			PTHR24068:SF70	UBIQUITIN-CONJUGATING ENZYME E2 E1
P00029	Huntington disease	P00807	Actin	ORNAN|Ensembl=ENSOANG00000007716|UniProtKB=F6UDX9	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00029	Huntington disease	P00780	Microtubule	XENTR|Xenbase=XB-GENE-6259095|UniProtKB=Q5BL39	Tubulin, beta 2	ISS	12932731	PubMed	PTHR11588:SF93	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MACMU|Ensembl=ENSMMUG00000016089|UniProtKB=F7GMZ4	Neuronal acetylcholine receptor subunit beta-2	ISS	15155845	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00551	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	XENTR|Xenbase=XB-GENE-479036|UniProtKB=Q640R7	Ras-related protein Rap-1b	ISS	10476970	PubMed	PTHR24070:SF382	RAS-RELATED PROTEIN RAP-1B
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000010953|UniProtKB=F1Q376	Phosphoinositide phospholipase C	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P02722	Acetate utilization	P02801	Acetate kinase	BACSU|EnsemblGenome=BSU29470|UniProtKB=P37877	Acetate kinase	ISS			PTHR21060:SF11	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00562	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04397	p53 pathway by glucose deprivation	P04640	p53	RAT|RGD=620863|UniProtKB=Q9JJP6	Tumor protein 63	TAS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CANLF|Ensembl=ENSCAFG00000018868|UniProtKB=F6Y037	Uncharacterized protein	ISS			PTHR13140:SF421	UNCONVENTIONAL MYOSIN-XVIIIA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	BOVIN|Ensembl=ENSBTAG00000020087|UniProtKB=Q08E45	Calcium/calmodulin-dependent protein kinase II alpha	ISS	10092204	PubMed	PTHR43940:SF5	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00318	PKCs	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IDA	89186920	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00059	p53 pathway	P04609	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	XENTR|Xenbase=XB-GENE-484032|UniProtKB=F6QWD3	Tyrosine-protein kinase receptor	ISS	11182407	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00009	Axon guidance mediated by netrin	P00366	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	8649368	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00047	PDGF signaling pathway	P01157	MAPKAPK2	PANTR|Ensembl=ENSPTRG00000001915|UniProtKB=H2Q104	Mitogen-activated protein kinase-activated protein kinase 2	ISS	8262198	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00020	FAS signaling pathway	P00599	Caspase3	CHICK|Ensembl=ENSGALG00000010638|UniProtKB=O93417	Caspase-3	IGI	11675509	PubMed	PTHR10454:SF198	CASPASE-3
P00021	FGF signaling pathway	P00644	p38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IGI	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00019	Endothelin signaling pathway	P00589	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	ARATH|TAIR=AT3G13670|UniProtKB=Q9LID3	Casein kinase-like protein	IDA	10617630	PubMed	PTHR11909:SF289	CASEIN KINASE-LIKE PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347740|UniProtKB=E9FXV8	Cytoplasmatic actin	ISS	14684598	PubMed	PTHR11937:SF277	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01199	Galpha	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	IDA	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00034	Integrin signalling pathway	P00924	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IPI	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00029	Huntington disease	P00775	Rac	MONDO|Ensembl=ENSMODG00000003244|UniProtKB=F6THF0	Uncharacterized protein	ISS	9254684	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	DROME|FlyBase=FBgn0002413|UniProtKB=O76324	Discs overgrown protein kinase	IDA	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00029	Huntington disease	P00782	alpha-Adaptin	MOUSE|MGI=MGI=101921|UniProtKB=P17426	AP-2 complex subunit alpha-1	IDA	11532990	PubMed	PTHR22780:SF19	AP-2 COMPLEX SUBUNIT ALPHA-1
P00034	Integrin signalling pathway	P00947	Laminin	CAEEL|WormBase=WBGene00016913|UniProtKB=Q18823	Laminin-like protein lam-2	IPI	2538453	PubMed	PTHR10574:SF79	LAMININ SUBUNIT GAMMA-1
P00005	Angiogenesis	P00238	Ras	DICDI|dictyBase=DDB_G0293434|UniProtKB=P15064	Ras-like protein rasG	ISS			PTHR24070:SF282	RAS GTPASE-RELATED
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00199	JNKK1	CANLF|Ensembl=ENSCAFG00000017851|UniProtKB=F1PBB6	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	BOVIN|Ensembl=ENSBTAG00000037985|UniProtKB=F1MCK3	Muscarinic acetylcholine receptor	ISS	12181435	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00005	Angiogenesis	P00210	eNOS	MONDO|Ensembl=ENSMODG00000003903|UniProtKB=F6S3S1	Nitric oxide synthase	ISS	10435050	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00005	Angiogenesis	P00206	Wnt	CHICK|Ensembl=ENSGALG00000005123|UniProtKB=Q9DEB8	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=1351344|UniProtKB=Q68ED2	Metabotropic glutamate receptor 7	ISS	11431030	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	DROME|FlyBase=FBgn0046332|UniProtKB=P83101	Putative glycogen synthase kinase-3 homolog	ISS	12615961	PubMed	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P05913	Enkephalin release	P05972	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	15313841	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01409	cPLA2	MACMU|Ensembl=ENSMMUG00000021423|UniProtKB=F7EEZ1	Phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00056	VEGF signaling pathway	P01407	Erk	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHICK|Gene=ACTA2|UniProtKB=P08023	Actin, aortic smooth muscle	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IDA	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00018	EGF receptor signaling pathway	P00551	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00019	Endothelin signaling pathway	P00591	PLCbeta	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	LEIMA|EnsemblGenome=LmjF.35.3960|UniProtKB=E9AFM1	Protein kinase A catalytic subunit isoform 2	ISS	10218114	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	IC	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00021	FGF signaling pathway	P00644	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00034	Integrin signalling pathway	P00912	Arp2/3	MACMU|Ensembl=ENSMMUG00000019342|UniProtKB=F6PVY4	Uncharacterized protein	ISS	12963527	gi	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	RAT|RGD=2738|UniProtKB=Q00960	Glutamate receptor ionotropic, NMDA 2B	IC	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	PANTR|Ensembl=ENSPTRG00000011756|UniProtKB=H2QHM0	Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	ISS			PTHR11405:SF5	CAD PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00830	Lipoxygenase	HUMAN|HGNC=433|UniProtKB=P16050	Arachidonate 15-lipoxygenase	TAS	12432925	PubMed	PTHR11771:SF33	ARACHIDONATE 15-LIPOXYGENASE
P00056	VEGF signaling pathway	P01411	Ras	BOVIN|Ensembl=ENSBTAG00000009778|UniProtKB=E1BMX0	Uncharacterized protein	ISS	99084794	PubMed	PTHR24070:SF186	GTPASE KRAS
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	STRCO|EnsemblGenome=CAB93364|UniProtKB=Q9KXR5	Carbamoyl-phosphate synthase small chain	ISS			PTHR11405:SF4	CARBAMOYL-PHOSPHATE SYNTHASE ARGININE-SPECIFIC SMALL CHAIN
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	RAT|RGD=2521|UniProtKB=P19020	D(3) dopamine receptor	ISS	11248120	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00051	TCA cycle	P01267	Citrate Synthase	CAEEL|WormBase=WBGene00000833|UniProtKB=P34575	Probable citrate synthase, mitochondrial	RCA			PTHR11739:SF8	CITRATE SYNTHASE, MITOCHONDRIAL
P00046	Oxidative stress response	P01129	JNK1/2	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	TAS	11707292	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00018	EGF receptor signaling pathway	P00561	STAT	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	14755057	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CHLRE|EnsemblGenome=CHLREDRAFT_129868|UniProtKB=A8IXZ0	Beta tubulin 1	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00009	Axon guidance mediated by netrin	P00363	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	BOVIN|Ensembl=ENSBTAG00000018445|UniProtKB=E1BK87	Uncharacterized protein	ISS	14698601	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00038	JAK/STAT signaling pathway	P01027	STAT	PANTR|Ensembl=ENSPTRG00000005121|UniProtKB=H2Q6A5	Uncharacterized protein	ISS	8085155	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04371	5-Hydroxytryptamine biosynthesis	P04399	Tryptophan hydroxylase	DROME|FlyBase=FBgn0035187|UniProtKB=Q9W0K2	GH12537p	ISS	14597720	PubMed	PTHR11473:SF23	TRYPTOPHAN 5-HYDROXYLASE 1
P00029	Huntington disease	P00807	Actin	RAT|RGD=1309504|UniProtKB=D3ZRN3	Protein Actbl2	ISS	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	CAEEL|WormBase=WBGene00020682|UniProtKB=Q9GZH3	Inosine-5'-monophosphate dehydrogenase	ISS			PTHR11911:SF111	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	TAS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00010	B cell activation	P00384	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IDA	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00006	Apoptosis signaling pathway	P00277	Bi1	ARATH|TAIR=AT5G47120|UniProtKB=Q9LD45	Bax inhibitor 1	ISS			PTHR23291:SF34	BAX INHIBITOR 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01275	P38	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00029	Huntington disease	P00796	Kainate receptor	PANTR|Ensembl=ENSPTRG00000011042|UniProtKB=H2QGF5	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00034	Integrin signalling pathway	P00941	Integrin alpha	HUMAN|HGNC=6148|UniProtKB=P20701	Integrin alpha-L	IPI	3487386	PubMed	PTHR23220:SF84	INTEGRIN ALPHA-L
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00392	I kappa B	HUMAN|HGNC=7800|UniProtKB=Q9UBC1	NF-kappa-B inhibitor-like protein 1	ISS	10811867	PubMed	PTHR15263:SF1	NF-KAPPA-B INHIBITOR-LIKE PROTEIN 1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00005	Angiogenesis	P00223	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P06959	CCKR signaling map	P07163	SRC @Galphaq	HUMAN|HGNC=11283|UniProtKB=P12931	Proto-oncogene tyrosine-protein kinase Src	RCA	21810446	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04393	Ras Pathway	P04557	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00060	Ubiquitin proteasome pathway	P01491	E2	YEAST|SGD=S000000286|UniProtKB=P15731	Ubiquitin-conjugating enzyme E2 4	ISS			PTHR24068:SF74	FI16911P1-RELATED
P04398	p53 pathway feedback loops 2	P04658	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	IGI	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00012	Cadherin signaling pathway	P00470	F-actin	PANTR|Ensembl=ENSPTRG00000018890|UniProtKB=Q5R1X3	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	THEMA|EnsemblGenome=TM_0578|UniProtKB=Q9WZ47	Pyrroline-5-carboxylate reductase	ISS			PTHR11645:SF0	PYRROLINE-5-CARBOXYLATE REDUCTASE
P00029	Huntington disease	P00805	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	RAT|RGD=69259|UniProtKB=O70240	Axin-2	IEP	9554852	PubMed	PTHR10845:SF103	AXIN-2
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	IC	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00049	Parkinson disease	P01214	CHIP	MONDO|Ensembl=ENSMODG00000016745|UniProtKB=F6YL96	Uncharacterized protein (Fragment)	ISS	12150907	PubMed	PTHR44284:SF1	E3 UBIQUITIN-PROTEIN LIGASE CHIP
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	RAT|RGD=619751|UniProtKB=O88302	Guanine nucleotide-binding protein subunit alpha-15	ISS	10629036	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P00056	VEGF signaling pathway	P01402	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	RCA			PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	PANTR|Ensembl=ENSPTRG00000006504|UniProtKB=H2R1H2	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF27	REGULATOR OF G-PROTEIN SIGNALING 6
P00019	Endothelin signaling pathway	P00566	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02741	Flavin biosynthesis	P02936	FAD synthetase	YEAST|SGD=S000002644|UniProtKB=Q03778	Riboflavin kinase	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	METAC|EnsemblGenome=MA_3023|UniProtKB=Q8TLL3	Glutamine--fructose-6-phosphate aminotransferase [isomerizing]	ISS			PTHR10937:SF0	GH12731P-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	CAEEL|WormBase=WBGene00004769|UniProtKB=P52166	Presenilin sel-12	IDA	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00019	Endothelin signaling pathway	P00589	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00035	Interferon-gamma signaling pathway	P00958	PIAS	MOUSE|MGI=MGI=1096566|UniProtKB=Q8C5D8	E3 SUMO-protein ligase PIAS2	ISS	8682149	PubMed	PTHR10782:SF12	E3 SUMO-PROTEIN LIGASE PIAS2
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	IPI	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	YEAST|SGD=S000004719|UniProtKB=Q12676	Dihydrofolate synthetase	ISS			PTHR11136:SF0	DIHYDROFOLATE SYNTHETASE-RELATED
P00019	Endothelin signaling pathway	P00577	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	IGI	96009592	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00018	EGF receptor signaling pathway	P00562	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_206575|UniProtKB=E9FUX0	Guanine nucleotide binding protein, beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	PANTR|Ensembl=ENSPTRG00000001992|UniProtKB=H2Q153	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF141	TRANSFORMING GROWTH FACTOR BETA-2
P00029	Huntington disease	P00796	Kainate receptor	MACMU|Ensembl=ENSMMUG00000022347|UniProtKB=F6ZCH5	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00005	Angiogenesis	P00206	Wnt	MOUSE|MGI=MGI=98953|UniProtKB=P04426	Proto-oncogene Wnt-1	ISS	14644163	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P02753	Methionine biosynthesis	P03024	Homocysteine transmethylase	CAEEL|WormBase=WBGene00010988|UniProtKB=Q09582	Probable methionine synthase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P00036	Interleukin signaling pathway	P00972	MNK1/2	HUMAN|HGNC=7110|UniProtKB=Q9BUB5	MAP kinase-interacting serine/threonine-protein kinase 1	TAS	Q9BUB5	SPACC	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6880|UniProtKB=Q13164	Mitogen-activated protein kinase 7	IDA	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TRYB2|Gene=Tb10.389.0490|UniProtKB=Q388U5	Protein kinase A catalytic subunit	ISS	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00024	Glycolysis	P00672	Phosphofructokinase-1	MACMU|Ensembl=ENSMMUG00000004173|UniProtKB=F6X3V0	Uncharacterized protein	RCA			PTHR13697:SF14	ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE, LIVER TYPE
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00015	Circadian clock system	P00505	Cry	PANTR|Ensembl=ENSPTRG00000003537|UniProtKB=H2Q3H0	Uncharacterized protein	ISS	14507900	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00029	Huntington disease	P00775	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	TAS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00010	B cell activation	P00385	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12874273	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05731	GABA-B receptor II signaling	P05754	Ggamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00012	Cadherin signaling pathway	P00475	Frizzled	RAT|RGD=61916|UniProtKB=Q08463	Frizzled-1	IDA	12549854	PubMed	PTHR11309:SF81	FRIZZLED-1
P00034	Integrin signalling pathway	P00928	alpha actinin	MOUSE|MGI=MGI=99678|UniProtKB=O88990	Alpha-actinin-3	IPI	2116421	PubMed	PTHR43947:SF6	ALPHA-ACTININ-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CHICK|Gene=CHRM4|UniProtKB=P17200	Muscarinic acetylcholine receptor M4	IDA	8100450	PubMed	PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00034	Integrin signalling pathway	P00926	GRAF	MACMU|Ensembl=ENSMMUG00000000419|UniProtKB=F6VDT1	Uncharacterized protein	ISS	8649427	PubMed	PTHR12552:SF4	RHO GTPASE-ACTIVATING PROTEIN 26
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	DROME|FlyBase=FBgn0001142|UniProtKB=P20477	Glutamine synthetase 1, mitochondrial	ISS			PTHR20852:SF44	GLUTAMINE SYNTHETASE 1, MITOCHONDRIAL
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	BOVIN|Ensembl=ENSBTAG00000008026|UniProtKB=P01175	Oxytocin-neurophysin 1	ISS	192340	OMIM	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01162	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	TAKRU|Ensembl=ENSTRUG00000016144|UniProtKB=H2UWE3	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	BOVIN|Ensembl=ENSBTAG00000016198|UniProtKB=E1B8D6	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ARATH|TAIR=AT5G59370|UniProtKB=P53494	Actin-4	IC	11889126	PubMed	PTHR11937:SF366	ACTIN-4
P02723	Adenine and hypoxanthine salvage pathway	P02808	Deoxyadenosine phosphorylase	THEMA|EnsemblGenome=TM_1737|UniProtKB=Q9X259	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	ORYSJ|EnsemblGenome=OS06G0149700|UniProtKB=Q5VND3	Cysteine synthase	ISS			PTHR10314:SF129	SUBFAMILY NOT NAMED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00006	Apoptosis signaling pathway	P00284	Flip	PANTR|Ensembl=ENSPTRG00000012798|UniProtKB=H2R695	CASP8 and FADD-like apoptosis regulator	ISS	9211860	PubMed	PTHR10454:SF8	CASP8 AND FADD-LIKE APOPTOSIS REGULATOR
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00036	Interleukin signaling pathway	P00970	Interleukin	PANTR|Ensembl=ENSPTRG00000020362|UniProtKB=H2QWB6	Interleukin-7	ISS	2643102	PubMed	PTHR45542:SF1	INTERLEUKIN-7
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00053	T cell activation	P01322	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01238	14-3-3	ORYSJ|EnsemblGenome=OS11G0546900|UniProtKB=Q2R2W2	14-3-3-like protein GF14-D	ISS	10918058	PubMed	PTHR18860:SF34	SUBFAMILY NOT NAMED
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00015	Circadian clock system	G01501	cry	RAT|RGD=620935|UniProtKB=Q923I8	Cryptochrome-2	IEP	14507900	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00591	PLCbeta	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	8687404	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00047	PDGF signaling pathway	P01142	p90RSK	MACMU|Ensembl=ENSMMUG00000005586|UniProtKB=F7G4I3	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF115	RIBOSOMAL PROTEIN S6 KINASE ALPHA-5
P00036	Interleukin signaling pathway	P00983	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P06959	CCKR signaling map	P07218	FAK2	HUMAN|HGNC=9612|UniProtKB=Q14289	Protein-tyrosine kinase 2-beta	RCA	10531323	PubMed	PTHR24418:SF94	PROTEIN-TYROSINE KINASE 2-BETA
P00034	Integrin signalling pathway	P00936	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	RAT|RGD=2713|UniProtKB=P10824	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	RAT|RGD=2742|UniProtKB=P23385	Metabotropic glutamate receptor 1	ISS	12351712	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00010	B cell activation	P00383	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00758	Phosducin	RAT|RGD=3277|UniProtKB=P20942	Phosducin	ISS	10360181	PubMed	PTHR21148:SF17	PHOSDUCIN
P00059	p53 pathway	P01486	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01067	AChE	CAEEL|WormBase=WBGene00000036|UniProtKB=G5EDV9	Carboxylic ester hydrolase	IC			PTHR43918:SF6	CARBOXYLIC ESTER HYDROLASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01063	CAT	MACMU|Ensembl=ENSMMUG00000004692|UniProtKB=F6RM01	Uncharacterized protein	ISS	92155737	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P02726	Aminobutyrate degradation	P02824	Succinate semi-aldehyde dehydrogenase	METAC|EnsemblGenome=MA_1355|UniProtKB=Q8TR29	Aldehyde dehydrogenase	ISS			PTHR43217:SF1	SUCCINATE SEMIALDEHYDE DEHYDROGENASE  NAD P +  SAD
P00036	Interleukin signaling pathway	P00966	mTOR	MOUSE|MGI=MGI=1928394|UniProtKB=Q9JLN9	Serine/threonine-protein kinase mTOR	ISS	7518356	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00049	Parkinson disease	P01230	Src kinase	RAT|RGD=2641|UniProtKB=Q62844	Tyrosine-protein kinase Fyn	IDA	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00018	EGF receptor signaling pathway	P00547	PP2A	HUMAN|HGNC=9300|UniProtKB=P62714	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	NAS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00896	Insulin IGF	PANTR|Ensembl=ENSPTRG00000003172|UniProtKB=P30410	Insulin	ISS			PTHR11454:SF9	INSULIN-RELATED
P00034	Integrin signalling pathway	P00925	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00029	Huntington disease	P00807	Actin	CIOIN|Ensembl=ENSCING00000000848|UniProtKB=F6SCP4	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00054	Toll receptor signaling pathway	P01341	Elk1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	ISS	11050086	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00059	p53 pathway	P04623	CBP	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00019	Endothelin signaling pathway	P00577	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	ISS	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P00006	Apoptosis signaling pathway	P00310	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	BACTN|EnsemblGenome=BT_0543|UniProtKB=Q8AAC2	Glutamine synthetase	ISS			PTHR42974:SF1	TYPE-3 GLUTAMINE SYNTHETASE
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	RAT|RGD=2736|UniProtKB=P35439	Glutamate receptor ionotropic, NMDA 1	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	IC	91072385	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00054	Toll receptor signaling pathway	P01369	MKK1	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IC	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000023202|UniProtKB=F7EU36	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P02753	Methionine biosynthesis	P03026	O-Succinyl homoserine lyase	FUSNN|EnsemblGenome=FN1746|UniProtKB=Q8RI67	Cystathionine beta-lyase	ISS			PTHR11808:SF72	CYSTATHIONINE BETA LYASE
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	ANOGA|EnsemblGenome=AGAP004476|UniProtKB=Q7QA16	AGAP004476-PA	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01238	14-3-3	RAT|RGD=62000|UniProtKB=P62260	14-3-3 protein epsilon	ISS	98119747	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00059	p53 pathway	P04634	Cdc2	DANRE|ZFIN=ZDB-GENE-040426-2741|UniProtKB=Q7ZWB1	Cyclin-dependent kinase 2	ISS	1846803	PubMed	PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00139	E-cadherin transmembrane fragment	HUMAN|HGNC=1748|UniProtKB=P12830	Cadherin-1	IDA	11953314	PubMed	PTHR24027:SF319	CADHERIN-1
P00057	Wnt signaling pathway	P01443	Phospholipase C	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00034	Integrin signalling pathway	P00941	Integrin alpha	HUMAN|HGNC=6144|UniProtKB=P53708	Integrin alpha-8	IPI	3487386	PubMed	PTHR23220:SF5	INTEGRIN ALPHA-8
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00010	B cell activation	P00373	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IGI	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00049	Parkinson disease	P01238	14-3-3	MONDO|Ensembl=ENSMODG00000010174|UniProtKB=F6TA21	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00018	EGF receptor signaling pathway	P00551	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IGI	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01153	GSK3	STRPU|EnsemblGenome=SPU_009263|UniProtKB=W4Y0P1	Uncharacterized protein	ISS	9609832	PubMed	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00049	Parkinson disease	P01236	Casein kinase II	HUMAN|HGNC=2458|UniProtKB=Q8NEV1	Casein kinase II subunit alpha 3	IDA	10617630	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IDA	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00018	EGF receptor signaling pathway	P00556	PLCgamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IGI	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00057	Wnt signaling pathway	P01472	Histone deacetylase	HUMAN|HGNC=4852|UniProtKB=Q13547	Histone deacetylase 1	IDA	10485845	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00562	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00193	SOS-1	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00034	Integrin signalling pathway	P00907	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00036	Interleukin signaling pathway	P00964	p90RSK	MOUSE|MGI=MGI=104558|UniProtKB=P18653	Ribosomal protein S6 kinase alpha-1	IGI	15226426	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	TAS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04395	Vasopressin synthesis	P04590	Vasopressin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00048	PI3 kinase pathway	P01181	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=97439|UniProtKB=P33534	Kappa-type opioid receptor	IDA	11259498	PubMed	PTHR24229:SF1	KAPPA-TYPE OPIOID RECEPTOR
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	IPI	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04374	5HT2 type receptor mediated signaling pathway	P04417	5HT transporter	MOUSE|MGI=MGI=96285|UniProtKB=Q60857	Sodium-dependent serotonin transporter	ISS	7681602	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P00036	Interleukin signaling pathway	P00996	STAT	PANTR|Ensembl=ENSPTRG00000009199|UniProtKB=H2QD19	Signal transducer and activator of transcription	ISS	7514531	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00059	p53 pathway	G04694	p110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02755	Methylmalonyl pathway	P03033	Propionyl-CoA carboxylase	THEMA|EnsemblGenome=TM_0716|UniProtKB=Q9WZH5	Acetyl-coenzyme A carboxyl transferase alpha chain / Acetyl-coenzyme A carboxyl transferase beta chain Propionyl-CoA carboxylase beta chain	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P00029	Huntington disease	P00781	Dynactin	MOUSE|MGI=MGI=107745|UniProtKB=O08788	Dynactin subunit 1	IPI	9454836	PubMed	PTHR18916:SF40	DYNACTIN SUBUNIT 1
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	HUMAN|HGNC=4574|UniProtKB=P48058	Glutamate receptor 4	ISS	10331083	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06959	CCKR signaling map	P07230	4E-BP1	HUMAN|HGNC=3288|UniProtKB=Q13541	Eukaryotic translation initiation factor 4E-binding protein 1	RCA	19339977	PubMed	PTHR12669:SF14	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1
P00057	Wnt signaling pathway	P01448	CBP	MACMU|Ensembl=ENSMMUG00000000893|UniProtKB=F6T7D0	Histone acetyltransferase p300	ISS	10769018	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00046	Oxidative stress response	P01129	JNK1/2	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00005	Angiogenesis	P00243	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	IC	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00054	Toll receptor signaling pathway	P01375	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	HUMAN|HGNC=236|UniProtKB=O95622	Adenylate cyclase type 5	IDA	1409703	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04393	Ras Pathway	P04546	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	IDA	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	P00543	ERK1-2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	CANLF|Ensembl=ENSCAFG00000007357|UniProtKB=F1PPK6	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P00021	FGF signaling pathway	P00644	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8687|UniProtKB=Q9Y5E7	Protocadherin beta-2	IDA	8120095	PubMed	PTHR24028:SF77	PROTOCADHERIN BETA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	HUMAN|HGNC=6091|UniProtKB=P06213	Insulin receptor	ISS	249616	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00047	PDGF signaling pathway	P01143	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	CANLF|Ensembl=ENSCAFG00000023094|UniProtKB=Q076A8	Developmental myosin heavy chain embryonic	ISS	10938134	PubMed	PTHR13140:SF427	MYOSIN-3
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00973	PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	SCHPO|PomBase=SPCC1223.08c|UniProtKB=P36591	Dihydrofolate reductase	ISS			PTHR22778:SF16	DIHYDROFOLATE REDUCTASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	CANLF|Ensembl=ENSCAFG00000009812|UniProtKB=E2RIA0	Uncharacterized protein	ISS	2433589	PubMed	PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P00049	Parkinson disease	P01238	14-3-3	CHICK|Gene_ORFName=RCJMB04_5e12|UniProtKB=Q5F3W6	14-3-3 protein gamma	ISS	22165492	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00054	Toll receptor signaling pathway	P01338	IkappaB	CANLF|Ensembl=ENSCAFG00000013418|UniProtKB=E2RML9	Uncharacterized protein	ISS	10811867	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00048	PI3 kinase pathway	P01181	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04384	Gamma-aminobutyric acid synthesis	P04480	GABA aminotransferase	MOUSE|MGI=MGI=2443582|UniProtKB=P61922	4-aminobutyrate aminotransferase, mitochondrial	ISS	10989446	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	TAS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00051	TCA cycle	P01268	Aconitase	RAT|RGD=621360|UniProtKB=Q9ER34	Aconitate hydratase, mitochondrial	RCA			PTHR43160:SF3	ACONITATE HYDRATASE, MITOCHONDRIAL
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05731	GABA-B receptor II signaling	P05754	Ggamma	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00004	Alzheimer disease-presenilin pathway	P00159	Nectin 1alpha intracellular fragment	MOUSE|MGI=MGI=1926483|UniProtKB=Q9JKF6	Nectin-1	IDA	12376527	PubMed	PTHR23277:SF69	NECTIN-1
P00034	Integrin signalling pathway	P00941	Integrin alpha	HUMAN|HGNC=6145|UniProtKB=Q13797	Integrin alpha-9	IPI	3487386	PubMed	PTHR23220:SF69	INTEGRIN ALPHA-9
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00021	FGF signaling pathway	P00648	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IGI	89186920	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00010	B cell activation	P00375	Calmodulin	PHYIT|EnsemblGenome=PITG_06514|UniProtKB=D0N511	Calmodulin	ISS			PTHR23050:SF245	AT16150P-RELATED
P00012	Cadherin signaling pathway	P00477	GSK3beta	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00052	TGF-beta signaling pathway	P01276	Co-Smads	HUMAN|HGNC=6770|UniProtKB=Q13485	Mothers against decapentaplegic homolog 4	TAS	9395284	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00199	JNKK1	PANTR|Ensembl=ENSPTRG00000008783|UniProtKB=H2QCA7	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00059	p53 pathway	G04704	KAI	RAT|RGD=69070|UniProtKB=O70352	CD82 antigen	ISS			PTHR19282:SF44	CD82 ANTIGEN
P00048	PI3 kinase pathway	P01192	p110	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ANOGA|EnsemblGenome=AGAP001676|UniProtKB=Q7PXZ8	AGAP001676-PA	ISS	10974003	PubMed	PTHR11937:SF368	ACTIN, INDIRECT FLIGHT MUSCLE
P00034	Integrin signalling pathway	P00944	Actin	HUMAN|HGNC=132|UniProtKB=P60709	Actin, cytoplasmic 1	IPI	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00056	VEGF signaling pathway	P01425	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00623	FGF	MACMU|Ensembl=ENSMMUG00000002035|UniProtKB=F6WYG1	Fibroblast growth factor	ISS			PTHR11486:SF71	FIBROBLAST GROWTH FACTOR 17
P00048	PI3 kinase pathway	P01188	Gbetagamma	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MACMU|Ensembl=ENSMMUG00000016675|UniProtKB=F6VTB5	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000005766|UniProtKB=F6W1H1	Uncharacterized protein	ISS	8120095	PubMed	PTHR43912:SF7	PROTOCADHERIN-20
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00034	Integrin signalling pathway	P00936	PI3K	XENTR|Xenbase=XB-GENE-6067221|UniProtKB=F6Z0J4	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00551	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01129	JNK1/2	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00009	Axon guidance mediated by netrin	P00359	NFAT	MACMU|Ensembl=ENSMMUG00000003370|UniProtKB=F7E8G2	Uncharacterized protein	ISS	12787506	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00030	Hypoxia response via HIF activation	P00823	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	14526383	PubMed	PTHR10048:SF14	PI-3 KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	CHICK|Ensembl=ENSGALG00000012894|UniProtKB=P30372	Muscarinic acetylcholine receptor M2	TAS	91373358	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04393	Ras Pathway	P04570	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00547	PP2A	DANRE|ZFIN=ZDB-GENE-040426-949|UniProtKB=Q7ZUS7	Serine/threonine-protein phosphatase	ISS			PTHR11668:SF24	SERINE/THREONINE-PROTEIN PHOSPHATASE 6 CATALYTIC SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	HUMAN|HGNC=237|UniProtKB=O43306	Adenylate cyclase type 6	IDA	10978539	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00029	Huntington disease	P00772	FIP-2	CHICK|Gene_ORFName=RCJMB04_29h8|UniProtKB=Q5ZI78	Tumor necrosis factor alpha-induced protein 8	ISS			PTHR12757:SF3	TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 8
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	PANTR|Ensembl=ENSPTRG00000005382|UniProtKB=H2Q6R9	10-formyltetrahydrofolate dehydrogenase	ISS			PTHR11699:SF131	MITOCHONDRIAL 10-FORMYLTETRAHYDROFOLATE DEHYDROGENASE
P00036	Interleukin signaling pathway	P00970	Interleukin	MOUSE|MGI=MGI=107936|UniProtKB=P70380	Interleukin-18	IDA	11710997	PubMed	PTHR45200:SF1	INTERLEUKIN-18
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PHYPA|Gene=PHYPADRAFT_225906|UniProtKB=A9TVP1	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	DANRE|ZFIN=ZDB-GENE-040426-2487|UniProtKB=Q803G3	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01444	Wnt	BOVIN|Ensembl=ENSBTAG00000001668|UniProtKB=F1N6L8	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2522|UniProtKB=P30729	D(4) dopamine receptor	IDA	2039532	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00010	B cell activation	P00398	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06831	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	RCA	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00054	Toll receptor signaling pathway	P01375	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01208	Hsp70	PHYIT|EnsemblGenome=PITG_00527|UniProtKB=D0MR13	Luminal-binding protein 3	ISS	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00059	p53 pathway	P01486	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	G04700	PAI	HUMAN|HGNC=8583|UniProtKB=P05121	Plasminogen activator inhibitor 1	ISS	10692390	PubMed	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P02773	S-adenosylmethionine biosynthesis	P03142	Cobalamin-dependent homocysteine transmethylase	PSEAE|EnsemblGenome=PA1843|UniProtKB=Q9I2Q2	Methionine synthase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P04395	Vasopressin synthesis	P04596	Endo Peptidase	ARATH|TAIR=AT1G20380|UniProtKB=F4HSS5	Prolyl oligopeptidase family protein	IC	9695945	PubMed	PTHR42881:SF2	PROLYL ENDOPEPTIDASE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	188830	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=1762|UniProtKB=P22223	Cadherin-3	IDA	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00018	EGF receptor signaling pathway	P00565	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00562	p38	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	IGI	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00007	Axon guidance mediated by semaphorins	P00341	Rho	XENTR|Xenbase=XB-GENE-489222|UniProtKB=Q28GJ8	Ras homolog gene family, member A	ISS	11360179	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00056	VEGF signaling pathway	P01413	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	1171954	gi	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00005	Angiogenesis	P00255	Notch	MOUSE|MGI=MGI=97364|UniProtKB=O35516	Neurogenic locus notch homolog protein 2	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	IGI	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00053	T cell activation	P01300	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00796	Kainate receptor	XENTR|Xenbase=XB-GENE-957124|UniProtKB=F7BDN8	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04398	p53 pathway feedback loops 2	P04657	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	TAS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05912	Dopamine receptor mediated signaling pathway	P05966	EPB41	HUMAN|HGNC=3379|UniProtKB=O43491	Band 4.1-like protein 2	IPI	12181426	PubMed	PTHR23280:SF17	BAND 4.1-LIKE PROTEIN 2
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	HUMAN|HGNC=7578|UniProtKB=P13535	Myosin-8	ISS	89264452	PubMed	PTHR13140:SF368	MYOSIN-8
P00057	Wnt signaling pathway	P01444	Wnt	ANOGA|EnsemblGenome=AGAP009734|UniProtKB=Q5TP56	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00054	Toll receptor signaling pathway	P01356	ERK2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00974	Receptor subunit beta	MACMU|Gene=CXCR2|UniProtKB=Q28519	C-X-C chemokine receptor type 2 (Fragment)	ISS	4504683	gi	PTHR10489:SF689	C-X-C CHEMOKINE RECEPTOR TYPE 2
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IGI	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	MOUSE|MGI=MGI=107421|UniProtKB=Q61139	Proprotein convertase subtilisin/kexin type 7	IDA			PTHR42884:SF12	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 7
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	9199552	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ORYSJ|EnsemblGenome=OS06G0699400|UniProtKB=Q5Z859	Mitogen-activated protein kinase 4	ISS	6491800	gi	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00012	Cadherin signaling pathway	P00475	Frizzled	MONDO|Ensembl=ENSMODG00000010505|UniProtKB=F7E9U1	Uncharacterized protein (Fragment)	ISS	11212302	PubMed	PTHR11309:SF81	FRIZZLED-1
P00019	Endothelin signaling pathway	P00568	PKC	YEAST|SGD=S000000201|UniProtKB=P24583	Protein kinase C-like 1	ISS	90322419	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	ORNAN|Ensembl=ENSOANG00000010227|UniProtKB=F7B5P0	Uncharacterized protein	ISS			PTHR10937:SF10	GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE  ISOMERIZING  2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS			PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00059	p53 pathway	G04700	PAI	MACMU|Ensembl=ENSMMUG00000009926|UniProtKB=F6Y5D7	Uncharacterized protein	ISS	18092159	gi	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	RAT|RGD=619965|UniProtKB=P26769	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00029	Huntington disease	P00807	Actin	ANOGA|EnsemblGenome=AGAP000651|UniProtKB=P84185	Actin-5C	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IDA	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00003	Alzheimer disease-amyloid secretase pathway	P00091	Aph-1	XENTR|Xenbase=XB-GENE-921428|UniProtKB=Q5EB22	Anterior pharynx defective 1 homolog A	ISS	12110170	PubMed	PTHR12889:SF3	GAMMA-SECRETASE SUBUNIT APH-1A
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	XENTR|Xenbase=XB-GENE-481916|UniProtKB=F6YF14	Presenilin	ISS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CAEEL|WormBase=WBGene00000064|UniProtKB=P10984	Actin-2	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00019	Endothelin signaling pathway	P00589	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01297	MEKK	MACMU|Ensembl=ENSMMUG00000012387|UniProtKB=F7EB20	Uncharacterized protein	RCA	11730323	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00057	Wnt signaling pathway	P01433	SIAH-1	ORYSJ|EnsemblGenome=OS01G0234900|UniProtKB=Q5NAX7	E3 ubiquitin-protein ligase	ISS	11389839	PubMed	PTHR10315:SF73	SUBFAMILY NOT NAMED
P00012	Cadherin signaling pathway	P00470	F-actin	MOUSE|MGI=MGI=87902|UniProtKB=P68134	Actin, alpha skeletal muscle	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00053	T cell activation	P01300	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	MOUSE|MGI=MGI=95815|UniProtKB=P39087	Glutamate receptor ionotropic, kainate 2	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00005	Angiogenesis	P00251	cPLA2	MACMU|Ensembl=ENSMMUG00000021423|UniProtKB=F7EEZ1	Phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00035	Interferon-gamma signaling pathway	P00960	PTP	CAEEL|WormBase=WBGene00004214|UniProtKB=G5EC24	Tyrosine-protein phosphatase non-receptor type ptp-2	TAS	14525967	PubMed	PTHR19134:SF428	TYROSINE-PROTEIN PHOSPHATASE CORKSCREW
P05912	Dopamine receptor mediated signaling pathway	P05957	K+ channel	MONDO|Ensembl=ENSMODG00000015769|UniProtKB=F6ZSC2	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01311	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	BACSU|EnsemblGenome=BSU17380|UniProtKB=P50620	Ribonucleoside-diphosphate reductase subunit alpha	ISS			PTHR11573:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00052	TGF-beta signaling pathway	P01275	P38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04393	Ras Pathway	P04547	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00899	IRS 1-4	PANTR|Ensembl=ENSPTRG00000012989|UniProtKB=H2QJJ4	Insulin receptor substrate 1	ISS	15110093	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00019	Endothelin signaling pathway	P00577	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IGI	129387	gi	PTHR10048:SF14	PI-3 KINASE
P00029	Huntington disease	P00780	Microtubule	ARATH|TAIR=AT1G75780|UniProtKB=P12411	Tubulin beta-1 chain	IDA	9454836	PubMed	PTHR11588:SF116	TUBULIN BETA-1 CHAIN-RELATED
P00057	Wnt signaling pathway	P01440	Cadherin	CANLF|Ensembl=ENSCAFG00000019028|UniProtKB=E2R790	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF96	CADHERIN-12
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00628	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00048	PI3 kinase pathway	P01182	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00053	T cell activation	P01300	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	MOUSE|MGI=MGI=109284|UniProtKB=Q61144	Presenilin-2	IDA	12885769	PubMed	PTHR10202:SF13	PRESENILIN-2
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8673|UniProtKB=Q9UN72	Protocadherin alpha-7	IDA	8120095	PubMed	PTHR24028:SF225	PROTOCADHERIN ALPHA-7
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BOVIN|Ensembl=ENSBTAG00000005714|UniProtKB=Q3ZC07	Actin, alpha cardiac muscle 1	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05962	DAT	MOUSE|MGI=MGI=94862|UniProtKB=Q61327	Sodium-dependent dopamine transporter	ISS	92107910	PubMed	PTHR11616:SF38	SODIUM-DEPENDENT DOPAMINE TRANSPORTER
P00018	EGF receptor signaling pathway	P00551	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01307	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	HUMAN|HGNC=11330|UniProtKB=P30872	Somatostatin receptor type 1	IDA			PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=107469|UniProtKB=Q8K3R3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	7822322	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00008	Axon guidance mediated by Slit/Robo	P00355	Rho	MONDO|Ensembl=ENSMODG00000000981|UniProtKB=F7ES59	Uncharacterized protein	ISS	14871999	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MACMU|Ensembl=ENSMMUG00000001672|UniProtKB=F7G3M7	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF32	REGULATOR OF G-PROTEIN SIGNALING 13
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00049	Parkinson disease	P01242	Casein kinase I	LEIMA|EnsemblGenome=LmjF.04.1210|UniProtKB=O96999	Putative casein kinase I	IDA	10617630	PubMed	PTHR11909:SF292	SUBFAMILY NOT NAMED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DANRE|ZFIN=ZDB-GENE-040625-35|UniProtKB=Q6IQL9	Novel actin protein	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04387	Histamine synthesis	P04493	Histidine decarboxylase	ANOGA|Gene=AgaP_AGAP009001|UniProtKB=Q7PWE0	AGAP009001-PA (Fragment)	ISS	1702422	PubMed	PTHR11999:SF68	HISTIDINE DECARBOXYLASE
P04393	Ras Pathway	P04560	AP1	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00218	STAT1	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	14755057	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEEL|WormBase=WBGene00004033|UniProtKB=P90980	Protein kinase C-like 2	ISS	3045562	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00025	Hedgehog signaling pathway	P00682	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	ISS	176892	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	RAT|RGD=621060|UniProtKB=O88777	Presenilin-2	IDA	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	TAKRU|Ensembl=ENSTRUG00000015959|UniProtKB=H2UV27	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00036	Interleukin signaling pathway	P00968	Ikk	RAT|RGD=621375|UniProtKB=Q9QY78	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00017	DNA replication	P00536	DNA Topisomerase	RAT|RGD=62048|UniProtKB=P41516	DNA topoisomerase 2-alpha	ISS			PTHR10169:SF46	DNA TOPOISOMERASE 2-ALPHA
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	MOUSE|MGI=MGI=102891|UniProtKB=P51829	Adenylate cyclase type 7	IC	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	BOVIN|Ensembl=ENSBTAG00000010837|UniProtKB=F1N3N9	Uncharacterized protein	ISS	12441358	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P00053	T cell activation	P01336	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IGI	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00048	PI3 kinase pathway	P01192	p110	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01150	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000021437|UniProtKB=H2QXZ6	Uncharacterized protein	ISS	10644715	PubMed	PTHR24356:SF175	SERINE/THREONINE-PROTEIN KINASE N3
P00048	PI3 kinase pathway	P01202	p85	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00018	EGF receptor signaling pathway	P00555	MKK4,7	CHICK|Ensembl=ENSGALG00000001001|UniProtKB=F1P3T1	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MOUSE|MGI=MGI=2150393|UniProtKB=Q91ZU9	Glutamate receptor ionotropic, NMDA 3B	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P00049	Parkinson disease	P01227	20S proteasome	MOUSE|MGI=MGI=1347014|UniProtKB=Q9R1P1	Proteasome subunit beta type-3	ISS	12859888	PubMed	PTHR11599:SF62	PROTEASOME SUBUNIT BETA TYPE-3
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00045	Notch signaling pathway	P01120	NIcs	BOVIN|Ensembl=ENSBTAG00000007909|UniProtKB=F1MPE9	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00005	Angiogenesis	P00237	FRP	HUMAN|HGNC=3959|UniProtKB=Q92765	Secreted frizzled-related protein 3	ISS	9118218	PubMed	PTHR11309:SF97	SECRETED FRIZZLED-RELATED PROTEIN 3
P00036	Interleukin signaling pathway	P00996	STAT	PANTR|Ensembl=ENSPTRG00000009199|UniProtKB=H2QD19	Signal transducer and activator of transcription	ISS	8732682	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00012	Cadherin signaling pathway	P00467	alpha-catenin	CHICK|Gene=CTNNA2|UniProtKB=P30997	Catenin alpha-2	IDA	1638632	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P00059	p53 pathway	G04694	p110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00539	14-3-3	MACMU|Ensembl=ENSMMUG00000004125|UniProtKB=F6XLR8	14-3-3 protein gamma	ISS	99360936	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	CAEEL|WormBase=WBGene00000552|UniProtKB=O16305	Calmodulin	ISS	9753452	PubMed	PTHR23050:SF236	CALMODULIN
P04393	Ras Pathway	P04567	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01438	PP2A	BOVIN|Ensembl=ENSBTAG00000020192|UniProtKB=A4FV55	PPP2R5C protein	ISS	8576224	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00624	14-3-3	PLAF7|EnsemblGenome=MAL8P1.69|UniProtKB=C0H4V6	14-3-3 protein	ISS	99404831	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00005	Angiogenesis	P00249	PAK	MONDO|Ensembl=ENSMODG00000018459|UniProtKB=F7CU42	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00048	PI3 kinase pathway	P01188	Gbetagamma	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	RAT|RGD=1309427|UniProtKB=Q3KRE8	Tubulin beta-2B chain	ISS	12932731	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00056	VEGF signaling pathway	P01408	Akt/PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01456	beta-arrestin	DROME|FlyBase=FBgn0040206|UniProtKB=Q9V393	Kurtz arrestin	IDA	11742073	PubMed	PTHR11792:SF17	KURTZ ARRESTIN
P00036	Interleukin signaling pathway	P00990	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9441|UniProtKB=P51817	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BOVIN|Gene=ACTG2|UniProtKB=Q5E9B5	Actin, gamma-enteric smooth muscle	ISS	3487386	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04392	P53 pathway feedback loops 1	P04539	p53	HUMAN|HGNC=15979|UniProtKB=Q9H3D4	Tumor protein 63	TAS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00018	EGF receptor signaling pathway	P00547	PP2A	HUMAN|HGNC=9299|UniProtKB=P67775	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	NAS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	IC	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00024	Glycolysis	P00679	Aldolase	MOUSE|MGI=MGI=87994|UniProtKB=P05064	Fructose-bisphosphate aldolase A	ISS	74094688	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00004	Alzheimer disease-presenilin pathway	P00117	E-cadherin C-terminal fragment	RAT|RGD=69279|UniProtKB=Q9R0T4	Cadherin-1	IDA	8120095	PubMed	PTHR24027:SF319	CADHERIN-1
P04398	p53 pathway feedback loops 2	P04665	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00367	NFAT	PANTR|Ensembl=ENSPTRG00000008260|UniProtKB=H2QBD7	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	ISS	9462517	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	MOUSE|MGI=MGI=2442166|UniProtKB=Q8C6N3	Synaptotagmin-15	RCA			PTHR10024:SF234	SYNAPTOTAGMIN-15
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02738	De novo purine biosynthesis	P02902	ADP reductase	PSEAE|EnsemblGenome=PA1156|UniProtKB=Q9I4I1	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00022	General transcription by RNA polymerase I	P00651	TAF-IA	CAEEL|WormBase=WBGene00006390|UniProtKB=Q7YTH5	TAF (TBP-associated transcription factor) family	ISS			PTHR12321:SF78	TAF  TBP-ASSOCIATED TRANSCRIPTION FACTOR  FAMILY
P00054	Toll receptor signaling pathway	P01354	NFkappaB	MOUSE|MGI=MGI=97897|UniProtKB=P15307	Proto-oncogene c-Rel	ISS	9480976	PubMed	PTHR24169:SF4	PROTO-ONCOGENE C-REL
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P02772	Pyruvate metabolism	P03141	Citrate Synthetase	ECOLI|EcoGene=EG10402|UniProtKB=P0ABH7	Citrate synthase	ISS	15800424	gi	PTHR42871:SF1	CITRATE SYNTHASE
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00021	FGF signaling pathway	P00643	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00572	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00047	PDGF signaling pathway	P01142	p90RSK	PANTR|Ensembl=ENSPTRG00000009477|UniProtKB=H2QDK7	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	RAT|RGD=2742|UniProtKB=P23385	Metabotropic glutamate receptor 1	ISS			PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01199	Galpha	CANLF|Ensembl=ENSCAFG00000019823|UniProtKB=E2R4I7	Uncharacterized protein	ISS			PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P00034	Integrin signalling pathway	P00947	Laminin	MACMU|Ensembl=ENSMMUG00000015084|UniProtKB=F6WVB2	Uncharacterized protein	ISS	2538453	PubMed	PTHR10574:SF270	LAMININ SUBUNIT GAMMA-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00034	Integrin signalling pathway	P00912	Arp2/3	HUMAN|HGNC=703|UniProtKB=Q92747	Actin-related protein 2/3 complex subunit 1A	IPI	12932731	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	HUMAN|HGNC=10004|UniProtKB=O75916	Regulator of G-protein signaling 9	IDA	8756726	PubMed	PTHR10845:SF170	REGULATOR OF G-PROTEIN SIGNALING 9
P00004	Alzheimer disease-presenilin pathway	P00114	actin	HUMAN|HGNC=17780|UniProtKB=Q562R1	Beta-actin-like protein 2	IDA	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00049	Parkinson disease	P01236	Casein kinase II	DICPU|Gene=DICPUDRAFT_26270|UniProtKB=F0Z8A7	Protein serine/threonine kinase	ISS	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P04393	Ras Pathway	P04570	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00296	DAXX	MACMU|Ensembl=ENSMMUG00000004287|UniProtKB=F6ZLZ0	Uncharacterized protein	ISS	10698492	PubMed	PTHR12766:SF7	DEATH DOMAIN-ASSOCIATED PROTEIN 6
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00059	p53 pathway	G04694	p110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	HUMAN|HGNC=6859|UniProtKB=O43318	Mitogen-activated protein kinase kinase kinase 7	IDA	10683140	PubMed	PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DANRE|ZFIN=ZDB-GENE-000330-4|UniProtKB=Q1MTI1	Uncharacterized protein	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	RAT|RGD=1307994|UniProtKB=B6RK61	Myosin heavy chain 7B	ISS	89264452	PubMed	PTHR13140:SF358	MYOSIN-7B
P00011	Blood coagulation	P00424	uPA	PANTR|Ensembl=ENSPTRG00000002646|UniProtKB=H2Q245	Uncharacterized protein	ISS	137114	gi	PTHR24264:SF38	UROKINASE-TYPE PLASMINOGEN ACTIVATOR
P00036	Interleukin signaling pathway	P00990	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	HUMAN|HGNC=4588|UniProtKB=O15399	Glutamate receptor ionotropic, NMDA 2D	ISS	11554549	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00047	PDGF signaling pathway	P01173	STAT	MONDO|Ensembl=ENSMODG00000011767|UniProtKB=F7CW94	Signal transducer and activator of transcription	ISS	12496413	PubMed	PTHR11801:SF19	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 4
P06211	BMP/activin signaling pathway-drosophila	P06256	Full-length  BMP orthologous ligand	DROME|FlyBase=FBgn0024234|UniProtKB=P27091	Protein 60A	RCA	9759503	PubMed	PTHR11848:SF54	PROTEIN 60A-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	HUMAN|HGNC=1950|UniProtKB=P11229	Muscarinic acetylcholine receptor M1	IDA	12915051	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000004896|UniProtKB=F7C2C6	Uncharacterized protein (Fragment)	ISS	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00012	Cadherin signaling pathway	P00468	Src	MACMU|Ensembl=ENSMMUG00000020131|UniProtKB=F7FWN4	Tyrosine-protein kinase	ISS	8054685	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00006	Apoptosis signaling pathway	P00303	c-Jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00021	FGF signaling pathway	P00623	FGF	BOVIN|Ensembl=ENSBTAG00000044043|UniProtKB=E1BP37	Fibroblast growth factor	ISS	11032730	PubMed	PTHR11486:SF72	FIBROBLAST GROWTH FACTOR 20
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	MACMU|Ensembl=ENSMMUG00000017985|UniProtKB=F7DN31	Uncharacterized protein	ISS	9362521	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00010	B cell activation	P00397	IKK	MACMU|Ensembl=ENSMMUG00000008351|UniProtKB=F7HRV5	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00017	DNA replication	P00527	Histones	PUCGT|EnsemblGenome=PGTG_06938|UniProtKB=E3KAH9	Histone H3	ISS	12413958	PubMed	PTHR11426:SF47	SUBFAMILY NOT NAMED
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00012	Cadherin signaling pathway	P00470	F-actin	TRIAD|EnsemblGenome=TriadG35956|UniProtKB=Q7YTV5	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04666	cyclin A	MOUSE|MGI=MGI=108069|UniProtKB=P51943	Cyclin-A2	ISS			PTHR10177:SF69	CYCLIN-A2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00053	T cell activation	P01318	PKC-theta	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00029	Huntington disease	P00799	JNK-2	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	HUMAN|HGNC=667|UniProtKB=P61586	Transforming protein RhoA	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00010	B cell activation	P00367	NFAT	BOVIN|Ensembl=ENSBTAG00000004368|UniProtKB=F1MSU2	Uncharacterized protein	ISS	12787506	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000001384|UniProtKB=F7GL73	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IC	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=16265|UniProtKB=Q9H1J7	Protein Wnt-5b	IDA	8717036	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00047	PDGF signaling pathway	P01160	IP3 receptor	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00644	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00030	Hypoxia response via HIF activation	P00819	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01431	LRP5/6	PANTR|Ensembl=ENSPTRG00000004701|UniProtKB=H2Q5G9	Low density lipoprotein receptor-related protein 6	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00045	Notch signaling pathway	P01099	Notch	MACMU|Ensembl=ENSMMUG00000017022|UniProtKB=F7HQZ9	Uncharacterized protein	ISS	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00045	Notch signaling pathway	P01104	Serrate	CANLF|Ensembl=ENSCAFG00000005627|UniProtKB=E2QUR0	Delta-like protein	ISS	10551863	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00059	p53 pathway	P04630	PP2A	XENTR|Xenbase=XB-GENE-957248|UniProtKB=Q6GLE6	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00038	JAK/STAT signaling pathway	P01027	STAT	HUMAN|HGNC=11366|UniProtKB=P42229	Signal transducer and activator of transcription 5A	ISS	96210005	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00048	PI3 kinase pathway	P01187	IR	BOVIN|Ensembl=ENSBTAG00000012687|UniProtKB=F1MV64	Tyrosine-protein kinase receptor	ISS	2983222	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P00009	Axon guidance mediated by netrin	P00366	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01239	Cul-1	XENTR|Xenbase=XB-GENE-945766|UniProtKB=Q1KMU1	Cullin-1	ISS	12628165	PubMed	PTHR11932:SF81	CULLIN-1
P00053	T cell activation	P01312	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DROME|FlyBase=FBgn0000046|UniProtKB=P10981	Actin-87E	IC	11889126	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00025	Hedgehog signaling pathway	P00692	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00034	Integrin signalling pathway	P00927	Rac	DICDI|dictyBase=DDB_G0279605|UniProtKB=P34148	Rho-related protein racB	IGI	11973360	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00006	Apoptosis signaling pathway	P00274	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00036	Interleukin signaling pathway	P00973	PKB	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P06212	DPP-SCW signaling pathway	P06273	DPP full length	DROME|FlyBase=FBgn0000490|UniProtKB=P07713	Protein decapentaplegic	IEA	9759503	PubMed	PTHR11848:SF234	PROTEIN DECAPENTAPLEGIC
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00021	FGF signaling pathway	P00644	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	12810719	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04398	p53 pathway feedback loops 2	G04714	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IDA	9514948	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00010	B cell activation	P00373	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	ISS	14698601	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	TAKRU|Ensembl=ENSTRUG00000014318|UniProtKB=H2UI49	Uncharacterized protein	IDA	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00008	Axon guidance mediated by Slit/Robo	P00351	Cxcr4	PANTR|Ensembl=ENSPTRG00000012501|UniProtKB=P61072	C-X-C chemokine receptor type 4	ISS	4503175	gi	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	2372396	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00990	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=107469|UniProtKB=Q8K3R3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	15611108	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00019	Endothelin signaling pathway	P00570	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00624	14-3-3	RAT|RGD=3980|UniProtKB=P63102	14-3-3 protein zeta/delta	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00021	FGF signaling pathway	P00644	p38	DANRE|ZFIN=ZDB-GENE-990415-257|UniProtKB=O42376	Mitogen-activated protein kinase 12	ISS	10851062	PubMed	PTHR24055:SF339	MITOGEN-ACTIVATED PROTEIN KINASE 12
P02777	Succinate to proprionate conversion	P03161	Methylmalonyl-CoA mutase	STRCO|Gene=CAB71920|UniProtKB=Q9L1V3	Methylmalonyll-CoA mutase	ISS			PTHR43589:SF3	SUBFAMILY NOT NAMED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IC	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	PHYPA|Gene=PHYPADRAFT_172686|UniProtKB=A9TYG6	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00012	Cadherin signaling pathway	P00465	TCF/LEF	XENTR|Xenbase=XB-GENE-1031985|UniProtKB=Q6GL68	Transcription factor 7-like 1	ISS	12356903	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00101	BACE-1	HUMAN|HGNC=933|UniProtKB=P56817	Beta-secretase 1	IDA	10956649	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IDA	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00054	Toll receptor signaling pathway	P01369	MKK1	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00005	Angiogenesis	P00237	FRP	BOVIN|Ensembl=ENSBTAG00000002107|UniProtKB=A7MB15	FZD1 protein	ISS	8717036	PubMed	PTHR11309:SF81	FRIZZLED-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06739	MEK1/2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	RCA	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	TAKRU|Ensembl=ENSTRUG00000007893|UniProtKB=H2T4Q4	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF751	SUBFAMILY NOT NAMED
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	CHICK|Ensembl=ENSGALG00000003820|UniProtKB=E1C8Y3	Actin-related protein 2/3 complex subunit 3	ISS	9359840	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	TAS	3755548	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=1594228|UniProtKB=D4A7P5	Protein Pcdhb20	ISS	8120095	PubMed	PTHR24028:SF81	PROTOCADHERIN BETA-14
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	CAEBR|Gene=CBG09510|UniProtKB=A8X8Y1	Protein CBG09510	ISS	10617630	PubMed	PTHR11909:SF19	ASATOR, ISOFORM D
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	XENTR|Xenbase=XB-GENE-876620|UniProtKB=F6TID6	Uncharacterized protein	ISS	9783586	PubMed	PTHR10814:SF4	AMINO-TERMINAL ENHANCER OF SPLIT-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DROME|FlyBase=FBgn0000047|UniProtKB=P83967	Actin, indirect flight muscle	IC	14684598	PubMed	PTHR11937:SF368	ACTIN, INDIRECT FLIGHT MUSCLE
P00030	Hypoxia response via HIF activation	P00823	PI3K	CAEEL|WormBase=WBGene00006932|UniProtKB=Q9TXI7	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	11927551	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P02741	Flavin biosynthesis	P02934	Riboflavin kinase	DEIRA|EnsemblGenome=DR_1008|UniProtKB=Q9RVL9	Riboflavin biosynthesis protein	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00035	Interferon-gamma signaling pathway	P00960	PTP	PANTR|Ensembl=ENSPTRG00000042397|UniProtKB=H2RIH8	Tyrosine-protein phosphatase non-receptor type	ISS	14534538	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P02723	Adenine and hypoxanthine salvage pathway	P02804	Hypoxanthine phosphoribosyl transferase	MOUSE|MGI=MGI=96217|UniProtKB=P00493	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF6	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00009	Axon guidance mediated by netrin	P00363	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00018	EGF receptor signaling pathway	P00540	MKK3,6	HUMAN|HGNC=6843|UniProtKB=P46734	Dual specificity mitogen-activated protein kinase kinase 3	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00021	FGF signaling pathway	P00632	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	CAEBR|Gene=CBG_05938|UniProtKB=H8WGV2	Protein CBR-ITR-1, isoform a	ISS	12880387	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00877	MLCK	HUMAN|HGNC=7590|UniProtKB=Q15746	Myosin light chain kinase, smooth muscle	IDA	600922	OMIM	PTHR45480:SF1	MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00048	PI3 kinase pathway	G01544	GADD45	MACMU|Ensembl=ENSMMUG00000014808|UniProtKB=F6W540	Growth arrest and DNA damage-inducible protein GADD45 alpha isoform 1	ISS	9827804	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P00005	Angiogenesis	P00254	GTPase	HUMAN|HGNC=668|UniProtKB=P62745	Rho-related GTP-binding protein RhoB	ISS	11973360	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P06959	CCKR signaling map	P07151	p52 SHC1	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	RCA	11607835	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	ISS	7565716	PubMed	PTHR10048:SF14	PI-3 KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04495	TSC1	MACMU|Ensembl=ENSMMUG00000009918|UniProtKB=F6Y6G0	Hamartin isoform 1	ISS	12820960	PubMed	PTHR15154:SF2	HAMARTIN
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-990415-257|UniProtKB=O42376	Mitogen-activated protein kinase 12	IDA	11707292	PubMed	PTHR24055:SF339	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00005	Angiogenesis	P00256	PLC-gamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00005	Angiogenesis	P00203	Erk	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01407	Erk	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00547	PP2A	MOUSE|MGI=MGI=1915107|UniProtKB=Q9CQR6	Serine/threonine-protein phosphatase 6 catalytic subunit	ISS			PTHR11668:SF24	SERINE/THREONINE-PROTEIN PHOSPHATASE 6 CATALYTIC SUBUNIT
P00056	VEGF signaling pathway	P01408	Akt/PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	G04671	proopiomelanocortin	PANTR|Ensembl=ENSPTRG00000011721|UniProtKB=H2R8Y3	Uncharacterized protein	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MACMU|Ensembl=ENSMMUG00000023785|UniProtKB=F7HTD6	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00059	p53 pathway	G01571	FAS	HUMAN|HGNC=11920|UniProtKB=P25445	Tumor necrosis factor receptor superfamily member 6	IGI	10327065	PubMed	PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00010	B cell activation	P00402	Jnk	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01449	Nemo-like Kinase	PANTR|Ensembl=ENSPTRG00000008904|UniProtKB=H2QCG7	Mitogen-activated protein kinase	ISS	10683140	PubMed	PTHR24055:SF179	SERINE/THREONINE-PROTEIN KINASE NLK
P00009	Axon guidance mediated by netrin	P00363	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	ORNAN|Ensembl=ENSOANG00000000493|UniProtKB=F7EPA8	Uncharacterized protein	ISS	12441358	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00048	PI3 kinase pathway	P01190	PDK1 ACT	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	IDA	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05918	p38 MAPK pathway	P06019	ATF1	HUMAN|HGNC=783|UniProtKB=P18846	Cyclic AMP-dependent transcription factor ATF-1	ISS	11390664	PubMed	PTHR22952:SF258	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-1
P00006	Apoptosis signaling pathway	P00318	PKCs	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00006	Apoptosis signaling pathway	P00313	IKK	RAT|RGD=1306661|UniProtKB=G3V926	Conserved helix-loop-helix ubiquitous kinase (Predicted)	ISS	9346484	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00559	MEK1-2	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04609	PI3K	DROME|FlyBase=FBgn0020622|UniProtKB=Q7KTZ2	Pi3K21B, isoform B	ISS	7937853	PubMed	PTHR10155:SF0	PI3K21B, ISOFORM B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00159	Nectin 1alpha intracellular fragment	MACMU|Ensembl=ENSMMUG00000008274|UniProtKB=F7HBK1	Uncharacterized protein	ISS	12376527	PubMed	PTHR23277:SF69	NECTIN-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00025	Hedgehog signaling pathway	P00683	Slimb	RAT|RGD=1359721|UniProtKB=F1LMH8	Protein Btrc	ISS	10074433	PubMed	PTHR44038:SF2	F-BOX/WD REPEAT-CONTAINING PROTEIN 1A
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02778	Sulfate assimilation	P03164	Adenylylsulfate kinase	EMENI|EnsemblGenome=CADANIAG00001431|UniProtKB=Q92203	Adenylyl-sulfate kinase	ISS			PTHR11055:SF1	PAPS SYNTHETASE, ISOFORM D
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	MOUSE|MGI=MGI=1278315|UniProtKB=Q91VN0	Low-density lipoprotein receptor-related protein 5	ISS	11907044	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00038	JAK/STAT signaling pathway	P01029	Serine kinase	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS			PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00634	MEKK1-5	MOUSE|MGI=MGI=1346874|UniProtKB=Q61084	Mitogen-activated protein kinase kinase kinase 3	ISS	11730323	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P02771	Pyrimidine Metabolism	P03124	Methylmalonate Semialdehyde Dehydrogenase	MONDO|Ensembl=ENSMODG00000006429|UniProtKB=F7EZH4	Uncharacterized protein	ISS	1527093	PubMed	PTHR43866:SF3	METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE  ACYLATING , MITOCHONDRIAL
P00005	Angiogenesis	P00243	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	BOVIN|Ensembl=ENSBTAG00000013631|UniProtKB=P15103	Glutamine synthetase	ISS			PTHR20852:SF45	GLUTAMINE SYNTHETASE
P02775	Salvage pyrimidine ribonucleotides	P03150	Uridine kinase	ARATH|TAIR=AT3G27440|UniProtKB=Q9LTY6	Uridine kinase-like protein 5	ISS			PTHR10285:SF75	URIDINE KINASE-LIKE PROTEIN 5
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	CANLF|Ensembl=ENSCAFG00000013171|UniProtKB=E2RP04	Uncharacterized protein	ISS	2779569	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00019	Endothelin signaling pathway	P00576	Pre-pro ET1-4	MOUSE|MGI=MGI=95284|UniProtKB=P22389	Endothelin-2	ISS			PTHR13874:SF9	ENDOTHELIN-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT1G59580|UniProtKB=Q39022	Mitogen-activated protein kinase 2	ISS	10851062	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00005	Angiogenesis	P00218	STAT1	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	12191995	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00572	MEK	CAEEL|WormBase=WBGene00003186|UniProtKB=Q10664	Dual specificity mitogen-activated protein kinase kinase mek-2	IGI	176872	OMIM	PTHR24361:SF629	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00029	Huntington disease	P00807	Actin	DANRE|ZFIN=ZDB-GENE-000329-3|UniProtKB=Q7ZVF9	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	PYRAE|EnsemblGenome=PAE0946|UniProtKB=Q8ZY49	Carbamoyl-phosphate synthase small chain	ISS			PTHR11405:SF4	CARBAMOYL-PHOSPHATE SYNTHASE ARGININE-SPECIFIC SMALL CHAIN
P00005	Angiogenesis	P00206	Wnt	BRAFL|Gene=BRAFLDRAFT_118160|UniProtKB=C3Z2P0	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF77	PROTEIN WNT-5
P00025	Hedgehog signaling pathway	P00682	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	RAT|RGD=2739|UniProtKB=Q00961	Glutamate receptor ionotropic, NMDA 2C	IC	14698601	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00029	Huntington disease	P00807	Actin	CAEEL|WormBase=WBGene00000063|UniProtKB=P0DM41	Actin-1	IDA	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00566	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	11251832	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	4506785	gi	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	HUMAN|HGNC=4581|UniProtKB=Q13003	Glutamate receptor ionotropic, kainate 3	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P04398	p53 pathway feedback loops 2	G04714	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00018	EGF receptor signaling pathway	P00552	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00624	14-3-3	MACMU|Ensembl=ENSMMUG00000006489|UniProtKB=F7EFF6	14-3-3 protein zeta/delta	ISS	92283271	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00578	eNOS	MOUSE|MGI=MGI=97362|UniProtKB=P70313	Nitric oxide synthase, endothelial	IGI	10435050	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00052	TGF-beta signaling pathway	P01275	P38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05915	Opioid proenkephalin pathway	P05992	met-Enkephalin	XENTR|Xenbase=XB-GENE-942760|UniProtKB=F6Y5F6	Uncharacterized protein	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00047	PDGF signaling pathway	P01162	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	CHICK|Ensembl=ENSGALG00000001476|UniProtKB=F1NSA8	Uncharacterized protein	ISS	1904317	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00012	Cadherin signaling pathway	P00474	Wnt	DROME|FlyBase=FBgn0010194|UniProtKB=P28466	Protein Wnt-5	IDA	8717036	PubMed	PTHR12027:SF77	PROTEIN WNT-5
P04393	Ras Pathway	P04547	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	RAT|RGD=631406|UniProtKB=Q8CHL0	Frizzled-5	ISS	8717036	PubMed	PTHR11309:SF126	FRIZZLED-5
P04393	Ras Pathway	P04566	Stat 1/3	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	IDA	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00010	B cell activation	P00375	Calmodulin	TAKRU|Ensembl=ENSTRUG00000003442|UniProtKB=H2S6Q5	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF197	CALMODULIN-LIKE PROTEIN 3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	12660731	PubMed	PTHR10048:SF14	PI-3 KINASE
P00011	Blood coagulation	P00409	PAI-2	MACMU|Ensembl=ENSMMUG00000016617|UniProtKB=F6TWU5	Uncharacterized protein	ISS	4505595	gi	PTHR11461:SF61	PLASMINOGEN ACTIVATOR INHIBITOR 2
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	IC	11535291	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00019	Endothelin signaling pathway	P00566	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00023	General transcription regulation	P00662	TFIIA complex	PANTR|Ensembl=ENSPTRG00000007129|UniProtKB=H2Q9J2	Transcription initiation factor IIA subunit 2	ISS	95241493	PubMed	PTHR10966:SF0	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	CAEEL|WormBase=WBGene00004287|UniProtKB=Q94124	Ras-related protein rac-2	ISS			PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P02734	Chorismate biosynthesis	P02870	3-Phosphoshikimate-1-carboxyvinyl transferase	RHOBA|EnsemblGenome=RB2278|UniProtKB=Q7UW43	3-phosphoshikimate 1-carboxyvinyltransferase	ISS			PTHR21090:SF5	PENTAFUNCTIONAL AROM POLYPEPTIDE
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	CANLF|Ensembl=ENSCAFG00000004381|UniProtKB=J9JH96	Uncharacterized protein	ISS	8314195	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00021	FGF signaling pathway	P00631	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	8479536	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00036	Interleukin signaling pathway	P00984	MEK	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS			PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00029	Huntington disease	P00807	Actin	TRIVA|Gene=TVAG_090470|UniProtKB=A2FA04	Actin	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	XENTR|Xenbase=XB-GENE-491618|UniProtKB=Q6P378	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P05918	p38 MAPK pathway	P06034	MKK4	MOUSE|MGI=MGI=1346869|UniProtKB=P47809	Dual specificity mitogen-activated protein kinase kinase 4	RCA	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00777	CBP	PANTR|Ensembl=ENSPTRG00000014418|UniProtKB=H2QLS0	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	ANOGA|EnsemblGenome=AGAP001478|UniProtKB=Q7PXM3	AGAP001478-PA	IC	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008422|UniProtKB=F6VUT7	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	IDA	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=87935|UniProtKB=P30545	Alpha-2B adrenergic receptor	IDA	11781138	PubMed	PTHR24248:SF26	ALPHA-2B ADRENERGIC RECEPTOR
P00010	B cell activation	P00379	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00034	Integrin signalling pathway	P00918	Caveolin	HUMAN|HGNC=1527|UniProtKB=Q03135	Caveolin-1	IPI	9741627	PubMed	PTHR10844:SF18	CAVEOLIN-1
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	SCHPO|PomBase=SPBC12D12.04c|UniProtKB=P36583	Protein kinase C-like 2	TAS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	CHICK|Ensembl=ENSGALG00000010273|UniProtKB=P48463	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00206	Wnt	HUMAN|HGNC=12784|UniProtKB=P41221	Protein Wnt-5a	ISS	8717036	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00018	EGF receptor signaling pathway	P00560	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00807	Actin	DANRE|ZFIN=ZDB-GENE-000329-1|UniProtKB=Q7ZVI7	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	HUMAN|HGNC=7881|UniProtKB=P46531	Neurogenic locus notch homolog protein 1	IDA	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000013632|UniProtKB=E1B965	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00012	Cadherin signaling pathway	P00467	alpha-catenin	RAT|RGD=1359485|UniProtKB=Q5U302	Catenin (Cadherin associated protein), alpha 1	ISS	1904011	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P05913	Enkephalin release	P05974	G-Protein (i)	YEAST|SGD=S000005738|UniProtKB=P18851	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00049	Parkinson disease	P01211	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10875333	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	DANRE|ZFIN=ZDB-GENE-020503-1|UniProtKB=Q1LWJ4	Tyrosine-protein kinase receptor	ISS	11182407	gi	PTHR24416:SF498	TYROSINE-PROTEIN KINASE RECEPTOR
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00029	Huntington disease	P00807	Actin	PANTR|Ensembl=ENSPTRG00000006890|UniProtKB=H2Q943	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01173	STAT	PANTR|Ensembl=ENSPTRG00000009199|UniProtKB=H2QD19	Signal transducer and activator of transcription	ISS	7514531	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00012	Cadherin signaling pathway	P00473	P120	MACMU|Ensembl=ENSMMUG00000012366|UniProtKB=F6QHE6	Uncharacterized protein	ISS			PTHR10372:SF6	CATENIN DELTA-1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	DICDI|dictyBase=DDB_G0281385|UniProtKB=P32253	Ras-like protein rasC	ISS	94119591	PubMed	PTHR24070:SF251	RAS-LIKE PROTEIN RASC
P00057	Wnt signaling pathway	P01443	Phospholipase C	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IDA	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	DANRE|ZFIN=ZDB-GENE-040718-93|UniProtKB=Q6DGZ5	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	CAEEL|WormBase=WBGene00001679|UniProtKB=P17343	Guanine nucleotide-binding protein subunit beta-1	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00057	Wnt signaling pathway	P01451	Galpha	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	IDA	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00561	STAT	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00029	Huntington disease	P00775	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00053	T cell activation	P01322	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	IGI	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00012	Cadherin signaling pathway	P00464	Fyn	XENTR|Xenbase=XB-GENE-6053489|UniProtKB=F6S8L5	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P04398	p53 pathway feedback loops 2	P04657	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00029	Huntington disease	P00812	Caspase 3	CANLF|Ensembl=ENSCAFG00000007750|UniProtKB=Q8MKI5	Caspase-3	IDA	9323209	PubMed	PTHR10454:SF198	CASPASE-3
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	10693759	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01457	GBeta	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01081	Ca2+ channel	MOUSE|MGI=MGI=88295|UniProtKB=O08532	Voltage-dependent calcium channel subunit alpha-2/delta-1	ISS	21601730	PubMed	PTHR10166:SF6	VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-1
P00047	PDGF signaling pathway	P01154	Ras	PANTR|Ensembl=ENSPTRG00000010422|UniProtKB=H2QF84	RAB11B, member RAS oncogene family	ISS			PTHR24073:SF335	RAS-RELATED PROTEIN RAB-11B
P00005	Angiogenesis	P00217	STAT3	CANLF|Ensembl=ENSCAFG00000015213|UniProtKB=E2RB82	Signal transducer and activator of transcription	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00047	PDGF signaling pathway	P01147	Nck	MACMU|Ensembl=ENSMMUG00000007389|UniProtKB=F7E0A3	Cytoplasmic protein NCK1 isoform 1	ISS	11689432	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	DANRE|ZFIN=ZDB-GENE-030131-8013|UniProtKB=F1QBT6	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00021	FGF signaling pathway	P00629	PP2A	DANRE|ZFIN=ZDB-GENE-030904-6|UniProtKB=Q7ZUQ2	Ppp2r5e1 protein	ISS	10092233	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	PANTR|Ensembl=ENSPTRG00000028542|UniProtKB=H2R591	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF79	FRIZZLED-9
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ORYSJ|EnsemblGenome=OS11G0163100|UniProtKB=Q67G20	Actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04393	Ras Pathway	P04552	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00048	PI3 kinase pathway	P01192	p110	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05918	p38 MAPK pathway	P06025	SRF	MACMU|Ensembl=ENSMMUG00000000033|UniProtKB=F7G4D2	Uncharacterized protein	ISS	15170389	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P04393	Ras Pathway	P04542	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00256	PLC-gamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00036	Interleukin signaling pathway	P00962	ELK	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	IDA	3183861	gi	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CANLF|Ensembl=ENSCAFG00000005662|UniProtKB=E2R907	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	DROME|FlyBase=FBgn0040507|UniProtKB=Q9W038	ACXD, isoform A	ISS			PTHR11920:SF338	ACXA, ISOFORM A-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	DAPPU|EnsemblGenome=DAPPUDRAFT_301818|UniProtKB=E9I1I7	Putative uncharacterized protein	ISS	20148920	PubMed	PTHR24070:SF385	GTPASE HRAS
P00047	PDGF signaling pathway	P01160	IP3 receptor	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00037	Ionotropic glutamate receptor pathway	P01001	KA4	HUMAN|HGNC=4582|UniProtKB=Q16099	Glutamate receptor ionotropic, kainate 4	IC	12871085	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00048	PI3 kinase pathway	P01192	p110	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01471	alpha-catenin	MACMU|Ensembl=ENSMMUG00000017985|UniProtKB=F7DN31	Uncharacterized protein	ISS	1904011	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Gene=PLCD4|UniProtKB=P21671	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	12860966	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MOUSE|MGI=MGI=1933206|UniProtKB=A2AIR5	Protein Grin3a	ISS	11554549	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00005	Angiogenesis	P00203	Erk	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01408	Akt/PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00243	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00570	PKA	LEIMA|EnsemblGenome=LmjF.35.3960|UniProtKB=E9AFM1	Protein kinase A catalytic subunit isoform 2	ISS	14744463	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	MONDO|Ensembl=ENSMODG00000004411|UniProtKB=F6SV50	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF58	ACTIVIN RECEPTOR TYPE-1C
P00034	Integrin signalling pathway	P00916	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00006	Apoptosis signaling pathway	P00302	ATF	MACMU|Ensembl=ENSMMUG00000022313|UniProtKB=F6XDP0	Uncharacterized protein	ISS	11390664	PubMed	PTHR19304:SF10	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-7
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=1352756|UniProtKB=Q8K394	Inactive phospholipase C-like protein 2	ISS			PTHR10336:SF84	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2
P04398	p53 pathway feedback loops 2	P04649	Myc	CANLF|Gene=MYC|UniProtKB=Q28350	Myc proto-oncogene protein	TAS	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P04393	Ras Pathway	P04570	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05752	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01153	GSK3	DROME|FlyBase=FBgn0046332|UniProtKB=P83101	Putative glycogen synthase kinase-3 homolog	ISS	11995474	gi	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00056	VEGF signaling pathway	P01417	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00047	PDGF signaling pathway	P01167	Ets	MOUSE|MGI=MGI=1335079|UniProtKB=Q8VDK3	ETS-related transcription factor Elf-5	ISS	15298723	PubMed	PTHR11849:SF15	ETS-RELATED TRANSCRIPTION FACTOR ELF-5
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02752	Mannose metabolism	P03019	P-Mannose mutase	CANLF|Ensembl=ENSCAFG00000019010|UniProtKB=E2R832	Phosphomannomutase	ISS	11042159	PubMed	PTHR10466:SF2	PHOSPHOMANNOMUTASE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MACMU|Ensembl=ENSMMUG00000013518|UniProtKB=F6Z7K1	Uncharacterized protein	ISS			PTHR13140:SF291	UNCONVENTIONAL MYOSIN-IA
P00053	T cell activation	P01330	IKK	MOUSE|MGI=MGI=99484|UniProtKB=Q60680	Inhibitor of nuclear factor kappa-B kinase subunit alpha	IGI	9346484	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	IC	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	RAT|RGD=2917|UniProtKB=P15127	Insulin receptor	ISS	11182407	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00057	Wnt signaling pathway	P01465	Ggamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	CAEEL|WormBase=WBGene00001745|UniProtKB=Q7KPV0	G protein, Subunit Alpha	ISS			PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00005	Angiogenesis	P00234	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12748278	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00060	Ubiquitin proteasome pathway	P01491	E2	ARATH|TAIR=AT3G08690|UniProtKB=P35134	Ubiquitin-conjugating enzyme E2 11	ISS			PTHR24068:SF55	UBIQUITIN-CONJUGATING ENZYME E2 11-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04397	p53 pathway by glucose deprivation	P04640	p53	BOVIN|Ensembl=ENSBTAG00000001069|UniProtKB=P67939	Cellular tumor antigen p53	TAS	14744434	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MOUSE|MGI=MGI=87887|UniProtKB=Q8R4G9	Neuronal acetylcholine receptor subunit alpha-3	IC	12098588	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MOUSE|MGI=MGI=95823|UniProtKB=Q03391	Glutamate receptor ionotropic, NMDA 2D	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00018	EGF receptor signaling pathway	G01511	SPRY	HUMAN|HGNC=15533|UniProtKB=Q9C004	Protein sprouty homolog 4	ISS	22024232	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000007084|UniProtKB=H2Q9G5	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00059	p53 pathway	P04633	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01312	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=30035|UniProtKB=Q8WYR1	Phosphoinositide 3-kinase regulatory subunit 5	ISS	129387	gi	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	PANTR|Ensembl=ENSPTRG00000019449|UniProtKB=H2QV01	Actin related protein 2/3 complex, subunit 1B, 41kDa	ISS	12963527	gi	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00019	Endothelin signaling pathway	P00583	cPLA2	MACMU|Ensembl=ENSMMUG00000021423|UniProtKB=F7EEZ1	Phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00057	Wnt signaling pathway	P01448	CBP	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00056	VEGF signaling pathway	P01413	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000008719|UniProtKB=F1MZX0	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	P01451	Galpha	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	IDA	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00005	Angiogenesis	P00215	Nck	HUMAN|HGNC=7664|UniProtKB=P16333	Cytoplasmic protein NCK1	IDA	12874226	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P00019	Endothelin signaling pathway	P00568	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	87218499	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00030	Hypoxia response via HIF activation	P00819	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	TAS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	TAS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00021	FGF signaling pathway	P00634	MEKK1-5	MACMU|Ensembl=ENSMMUG00000012387|UniProtKB=F7EB20	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00047	PDGF signaling pathway	P01143	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00549	EGF	RAT|RGD=3849|UniProtKB=P01134	Protransforming growth factor alpha	IGI	6981646	gi	PTHR10740:SF1	PROTRANSFORMING GROWTH FACTOR ALPHA
P00047	PDGF signaling pathway	P01152	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	8262392	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00019	Endothelin signaling pathway	P00589	Akt	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	IGI	12719720	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00371	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P06959	CCKR signaling map	P07225	RAC1-GDP	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	RCA	15331357	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P02742	Tetrahydrofolate biosynthesis	P02951	GTP cyclohydrolase	STRCO|EnsemblGenome=CAB42756|UniProtKB=Q9X8I3	GTP cyclohydrolase 1	ISS			PTHR11109:SF0	GTP CYCLOHYDROLASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DROME|FlyBase=FBgn0000044|UniProtKB=P53501	Actin-57B	IDA	10974003	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	IDA	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	MOUSE|MGI=MGI=96575|UniProtKB=P15208	Insulin receptor	TAS	11182407	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00645	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00254	GTPase	MOUSE|MGI=MGI=107949|UniProtKB=P62746	Rho-related GTP-binding protein RhoB	ISS	13679859	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	DANRE|ZFIN=ZDB-GENE-051202-1|UniProtKB=E7F101	Uncharacterized protein	ISS	11319238	PubMed	PTHR44391:SF2	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00944	Actin	RAT|RGD=628837|UniProtKB=P60711	Actin, cytoplasmic 1	IPI	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00010	B cell activation	P00381	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00642	MEK1-2	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00634	MEKK1-5	MONDO|Ensembl=ENSMODG00000006594|UniProtKB=F7AKA6	Uncharacterized protein	ISS	12878610	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00034	Integrin signalling pathway	P00925	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	94313981	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00059	p53 pathway	P04633	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00007	Axon guidance mediated by semaphorins	P00339	CRMP	PANTR|Ensembl=ENSPTRG00000020099|UniProtKB=H2QVX6	Uncharacterized protein	ISS	Q90635	SPACC	PTHR11647:SF56	DIHYDROPYRIMIDINASE-RELATED PROTEIN 2
P00005	Angiogenesis	P00239	Eph	MONDO|Ensembl=ENSMODG00000005556|UniProtKB=F7F3Y7	Uncharacterized protein	ISS	9990854	PubMed	PTHR11304:SF18	EPHRIN-B2
P02776	Serine glycine biosynthesis	P03157	Phosphoserine aminotransferase	MACMU|Ensembl=ENSMMUG00000011868|UniProtKB=F7H2J8	Phosphoserine aminotransferase	ISS	20886743	gi	PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	TAS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	ARATH|TAIR=AT3G43810|UniProtKB=P59220	Calmodulin-7	ISS	10487978	PubMed	PTHR23050:SF250	CALMODULIN-7
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00050	Plasminogen activating cascade	P01260	pro-MMP-3	HUMAN|HGNC=7173|UniProtKB=P08254	Stromelysin-1	IDA	3477804	PubMed	PTHR10201:SF215	STROMELYSIN-1
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	CAEBR|Gene=CBG18112|UniProtKB=A8XT20	Protein CBR-GLR-1	ISS	8804111	PubMed	PTHR18966:SF297	GLUTAMATE RECEPTOR 1
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MONDO|Ensembl=ENSMODG00000008382|UniProtKB=F7CDR6	Uncharacterized protein (Fragment)	ISS	11259498	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MACMU|Ensembl=ENSMMUG00000009679|UniProtKB=F6YBQ8	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04454	CRF	CHICK|Ensembl=ENSGALG00000015521|UniProtKB=Q703P0	Corticotropin releasing hormone	ISS	122560	OMIM	PTHR15035:SF9	CORTICOLIBERIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00321	HSP70	BOVIN|Ensembl=ENSBTAG00000025442|UniProtKB=P0CB32	Heat shock 70 kDa protein 1-like	ISS	12150907	PubMed	PTHR19375:SF210	HEAT SHOCK 70 KDA PROTEIN 1-LIKE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04393	Ras Pathway	P04560	AP1	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00005	Angiogenesis	P00219	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00047	PDGF signaling pathway	P01142	p90RSK	CANLF|Ensembl=ENSCAFG00000000828|UniProtKB=F6UWI0	Ribosomal protein S6 kinase	ISS	15526037	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00052	TGF-beta signaling pathway	P01275	P38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P02738	De novo purine biosynthesis	P02891	GDP kinase	STRCO|EnsemblGenome=CAB75393|UniProtKB=P50589	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00018	EGF receptor signaling pathway	P00564	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12874273	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00034	Integrin signalling pathway	P00924	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00060	Ubiquitin proteasome pathway	P01492	E1	CANLF|Ensembl=ENSCAFG00000007258|UniProtKB=E2R837	Uncharacterized protein	ISS			PTHR10953:SF5	SUMO-ACTIVATING ENZYME SUBUNIT 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	RAT|RGD=71014|UniProtKB=Q04400	Adenylate cyclase type 5	IC	1409703	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00003	Alzheimer disease-amyloid secretase pathway	P00091	Aph-1	HUMAN|HGNC=24080|UniProtKB=Q8WW43	Gamma-secretase subunit APH-1B	IDA	12110170	PubMed	PTHR12889:SF1	GAMMA-SECRETASE SUBUNIT APH-1B
P00046	Oxidative stress response	P01122	TRX	MOUSE|MGI=MGI=2389312|UniProtKB=Q6P902	Thioredoxin domain-containing protein 2	ISS			PTHR10438:SF107	THIOREDOXIN DOMAIN-CONTAINING PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00047	PDGF signaling pathway	P01150	PKC	SCHPO|PomBase=SPBC12D12.04c|UniProtKB=P36583	Protein kinase C-like 2	ISS	125549	gi	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00056	VEGF signaling pathway	P01407	Erk	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	92020947	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05731	GABA-B receptor II signaling	P05752	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04665	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05913	Enkephalin release	P05973	GPCR (i)	MOUSE|MGI=MGI=97438|UniProtKB=P32300	Delta-type opioid receptor	ISS	11259498	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	IDA	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01439	C-terminal Binding Protein	HUMAN|HGNC=2495|UniProtKB=P56545	C-terminal-binding protein 2	IDA	10375506	PubMed	PTHR10996:SF72	C-TERMINAL-BINDING PROTEIN 2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	TAKRU|Ensembl=ENSTRUG00000015938|UniProtKB=H2UUX5	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00025	Hedgehog signaling pathway	P00699	Su(fu)	CANLF|Ensembl=ENSCAFG00000010221|UniProtKB=E2RAI7	Suppressor of fused homolog	ISS	10920228	PubMed	PTHR10928:SF2	SUPPRESSOR OF FUSED HOMOLOG
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	CHICK|Ensembl=ENSGALG00000026748|UniProtKB=F1P493	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF728	MYOSIN HEAVY CHAIN, SKELETAL MUSCLE, ADULT
P00057	Wnt signaling pathway	P01435	SWI/SNF	MOUSE|MGI=MGI=1914243|UniProtKB=Q6P9Z1	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3	ISS	11532957	PubMed	PTHR13844:SF5	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D MEMBER 3
P00015	Circadian clock system	G01501	cry	HUMAN|HGNC=2384|UniProtKB=Q16526	Cryptochrome-1	IEP	10428031	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00019	Endothelin signaling pathway	P00586	Gq	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01312	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02747	Histidine biosynthesis	P02987	ATP phosphoribosyl transferase	LEPIN|EnsemblGenome=LA_1262|UniProtKB=Q8F6P1	ATP phosphoribosyltransferase	ISS			PTHR21403:SF4	ATP PHOSPHORIBOSYLTRANSFERASE
P06664	Gonadotropin-releasing hormone receptor pathway	G06886	CGA	MOUSE|MGI=MGI=88390|UniProtKB=P01216	Glycoprotein hormones alpha chain	RCA	15927770	PubMed	PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P00052	TGF-beta signaling pathway	P01276	Co-Smads	HUMAN|HGNC=6770|UniProtKB=Q13485	Mothers against decapentaplegic homolog 4	TAS	10693808	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00036	Interleukin signaling pathway	P00985	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	15210700	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	CHICK|Ensembl=ENSGALG00000026034|UniProtKB=Q9PWA0	Regulator of G-protein signaling 17	IDA	8756726	PubMed	PTHR10845:SF196	REGULATOR OF G-PROTEIN SIGNALING 17
P00048	PI3 kinase pathway	P01178	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	15210125	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00018	EGF receptor signaling pathway	P00558	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05918	p38 MAPK pathway	P06020	p38delta	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	RCA	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04380	Cortocotropin releasing factor receptor signaling pathway	P04455	beta-endorphin	DANRE|ZFIN=ZDB-GENE-030513-2|UniProtKB=Q7ZT18	Pro-opiomelanocortin protein	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00029	Huntington disease	P00807	Actin	MOUSE|MGI=MGI=104589|UniProtKB=P63268	Actin, gamma-enteric smooth muscle	IDA	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P02788	Xanthine and guanine salvage pathway	P03245	Guanine phosphoribosyl transferase	DEIRA|EnsemblGenome=DR_1376|UniProtKB=Q9RUK8	Hypoxanthine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00053	T cell activation	P01330	IKK	BOVIN|Ensembl=ENSBTAG00000007591|UniProtKB=Q95KV1	Inhibitor of nuclear factor kappa-B kinase subunit alpha	IGI	12813046	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P05913	Enkephalin release	P05972	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00006	Apoptosis signaling pathway	P00260	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	ARATH|TAIR=AT1G08700|UniProtKB=O64668	Presenilin-like protein At1g08700	TAS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00046	Oxidative stress response	P01131	MKP5	PANTR|Ensembl=ENSPTRG00000004704|UniProtKB=H2Q5H0	Dual specificity phosphatase 16	ISS			PTHR10159:SF37	DUAL SPECIFICITY PROTEIN PHOSPHATASE 16
P02785	Valine biosynthesis	P03215	Branched chain amino acid aminotransferase	ARATH|TAIR=AT1G50090|UniProtKB=Q9LPM8	Putative branched-chain-amino-acid aminotransferase 7	ISS			PTHR42825:SF4	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 6-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00034	Integrin signalling pathway	P00944	Actin	CRYNJ|EnsemblGenome=CNA04650|UniProtKB=Q5KP06	Actin	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00034	Integrin signalling pathway	P00951	Jnk	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	IDA	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00057	Wnt signaling pathway	P01464	Pygo	CANLF|Ensembl=ENSCAFG00000015935|UniProtKB=F1Q0S3	Uncharacterized protein	ISS	11955446	PubMed	PTHR23194:SF3	PYGOPUS HOMOLOG 1
P00036	Interleukin signaling pathway	P00983	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00017	DNA replication	P00536	DNA Topisomerase	MACMU|Ensembl=ENSMMUG00000011112|UniProtKB=F6TZC2	Uncharacterized protein	ISS			PTHR10290:SF5	DNA TOPOISOMERASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05731	GABA-B receptor II signaling	P05755	Gbeta	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	PANTR|Ensembl=ENSPTRG00000001477|UniProtKB=H2Q0A5	Tyrosine-protein kinase receptor	ISS	11182407	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00047	PDGF signaling pathway	P01172	c-Myc	DROME|FlyBase=FBgn0262656|UniProtKB=Q9W4S7	Myc protein	ISS	9271375	PubMed	PTHR11514:SF95	MYC PROTEIN
P00019	Endothelin signaling pathway	P00589	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	MOUSE|MGI=MGI=95794|UniProtKB=A2ARV4	Low-density lipoprotein receptor-related protein 2	ISS	11907044	PubMed	PTHR44025:SF5	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	HUMAN|HGNC=12412|UniProtKB=Q13885	Tubulin beta-2A chain	ISS	9454836	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=2150308|UniProtKB=Q8K4D7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1	ISS	12860966	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00632	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04393	Ras Pathway	P04561	SRF	CANLF|Ensembl=ENSCAFG00000001829|UniProtKB=F1PH12	Uncharacterized protein	ISS	15647354	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	MOUSE|MGI=MGI=95801|UniProtKB=O70291	G protein-coupled receptor kinase 4	IDA	8288567	PubMed	PTHR24355:SF14	G PROTEIN-COUPLED RECEPTOR KINASE 4
P04393	Ras Pathway	P04558	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IDA	12810719	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02783	Tryptophan biosynthesis	P03208	Tryptophan synthase B	CHLRE|EnsemblGenome=CHLREDRAFT_9823|UniProtKB=A8IFZ9	Tryptophan synthase beta subunit	ISS			PTHR42882:SF3	TRYPTOPHAN SYNTHASE BETA CHAIN 1, CHLOROPLASTIC-RELATED
P04393	Ras Pathway	P04553	PAK	RAT|RGD=3250|UniProtKB=P35465	Serine/threonine-protein kinase PAK 1	IDA	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	94280860	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00019	Endothelin signaling pathway	P00570	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	8787761	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	BOVIN|Ensembl=ENSBTAG00000013632|UniProtKB=E1B965	Uncharacterized protein	ISS	11431030	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CAEEL|WormBase=WBGene00001187|UniProtKB=Q8MQA1	Uncharacterized protein	IC	91056091	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MONDO|Ensembl=ENSMODG00000024011|UniProtKB=F7CGM4	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00034	Integrin signalling pathway	P00942	Fyn	BOVIN|Ensembl=ENSBTAG00000011851|UniProtKB=A0JNB0	Tyrosine-protein kinase Fyn	ISS	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CHICK|Ensembl=ENSGALG00000027629|UniProtKB=Q5ZJ03	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00059	p53 pathway	P01481	ATM/ATR	DROME|FlyBase=FBgn0004367|UniProtKB=Q9VXG8	Serine/threonine-protein kinase ATR	ISS			PTHR11139:SF69	SERINE/THREONINE-PROTEIN KINASE ATR
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02733	Carnitine metabolism	P02866	Carnitine dehydratase	PSEAE|EnsemblGenome=PA3733|UniProtKB=Q9HXQ9	Uncharacterized protein	ISS			PTHR43949:SF1	ACETYL-COA:OXALATE COA-TRANSFERASE
P00059	p53 pathway	P04614	Cyclin B	MACMU|Ensembl=ENSMMUG00000018142|UniProtKB=F7GX97	G2/mitotic-specific cyclin-B1	ISS	1019642	gi	PTHR10177:SF193	G2/MITOTIC-SPECIFIC CYCLIN-B1
P00019	Endothelin signaling pathway	P00567	PKG	HUMAN|HGNC=9414|UniProtKB=Q13976	cGMP-dependent protein kinase 1	IGI	12855709	PubMed	PTHR24353:SF68	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00182	p38MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05915	Opioid proenkephalin pathway	P05988	peptide E	XENTR|Xenbase=XB-GENE-942760|UniProtKB=F6Y5F6	Uncharacterized protein	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00924	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IPI	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01451	Galpha	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	IDA	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	DANRE|ZFIN=ZDB-GENE-050417-441|UniProtKB=Q567Y8	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00561	STAT	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	12191995	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00019	Endothelin signaling pathway	P00589	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00825	Thioredoxin	STRCO|EnsemblGenome=CAB42711|UniProtKB=P52230	Thioredoxin-1	ISS			PTHR10438:SF215	THIOREDOXIN DOMAIN-CONTAINING PROTEIN, MITOCHONDRIAL
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05941	GRK3	CHICK|Ensembl=ENSGALG00000005518|UniProtKB=F1NTL1	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P00021	FGF signaling pathway	P00627	ERK1-2	ORYSJ|EnsemblGenome=OS02G0148100|UniProtKB=Q6Z437	Mitogen-activated protein kinase 3	ISS			PTHR24055:SF216	SUBFAMILY NOT NAMED
P02721	ATP synthesis	P02799	Cyt bc1	MOUSE|MGI=MGI=1913695|UniProtKB=Q9D0M3	Cytochrome c1, heme protein, mitochondrial	IEA	12477932	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00018	EGF receptor signaling pathway	P00551	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	CAEEL|WormBase=WBGene00001745|UniProtKB=Q7KPV0	G protein, Subunit Alpha	ISS			PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00046	Oxidative stress response	P01121	MKK3/6	CHICK|Ensembl=ENSGALG00000004735|UniProtKB=F1NHE1	Uncharacterized protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00057	Wnt signaling pathway	P01466	Diversin	PANTR|Ensembl=ENSPTRG00000018421|UniProtKB=H2QTE6	Uncharacterized protein	ISS	12183362	PubMed	PTHR24203:SF7	ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	BOVIN|Ensembl=ENSBTAG00000019716|UniProtKB=P79255	Interleukin-8	ISS	124361	gi	PTHR10179:SF70	INTERLEUKIN-8
P00005	Angiogenesis	P00223	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00580	ET-RA/B	CHICK|Ensembl=ENSGALG00000010013|UniProtKB=O73739	Endothelin receptor type A	IGI	99030274	PubMed	PTHR24243:SF31	ENDOTHELIN-1 RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	RAT|RGD=1304556|UniProtKB=P63259	Actin, cytoplasmic 2	ISS	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	TAS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00059	p53 pathway	P04633	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00624	14-3-3	MONDO|Ensembl=ENSMODG00000013658|UniProtKB=F6TY10	Uncharacterized protein	ISS	1317796	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00018	EGF receptor signaling pathway	P00551	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IGI	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00053	T cell activation	P01319	PAK	HUMAN|HGNC=8591|UniProtKB=Q13177	Serine/threonine-protein kinase PAK 2	IDA	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00056	VEGF signaling pathway	P01417	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01440	Cadherin	ANOGA|EnsemblGenome=AGAP006256|UniProtKB=Q7PPB2	AGAP006256-PA	ISS	8120095	PubMed	PTHR43956:SF5	CADHERIN 74A, ISOFORM A
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000006232|UniProtKB=H2Q845	Serine/threonine-protein kinase	ISS	8078925	PubMed	PTHR22968:SF9	SERINE/THREONINE-PROTEIN KINASE D1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	MOUSE|MGI=MGI=1351345|UniProtKB=P47743	Metabotropic glutamate receptor 8	IC	9407094	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00037	Ionotropic glutamate receptor pathway	P01026	KA	PANTR|Ensembl=ENSPTRG00000000543|UniProtKB=H2PYN8	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00053	T cell activation	P01318	PKC-theta	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IGI	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=12778|UniProtKB=O14904	Protein Wnt-9a	TAS	11266476	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P05918	p38 MAPK pathway	P06027	CREB	XENTR|Xenbase=XB-GENE-945015|UniProtKB=F6QA46	Uncharacterized protein	ISS	11390664	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06802	IR	MOUSE|MGI=MGI=96575|UniProtKB=P15208	Insulin receptor	RCA	14500580	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P02738	De novo purine biosynthesis	P02908	Phosphoribosylamine glycine ligase	STRCO|EnsemblGenome=CAB56348|UniProtKB=Q9RKL4	Phosphoribosylamine--glycine ligase	ISS			PTHR43472:SF1	PHOSPHORIBOSYLAMINE--GLYCINE LIGASE
P00048	PI3 kinase pathway	P01205	NOS	MACMU|Ensembl=ENSMMUG00000020437|UniProtKB=F6WEB2	Nitric oxide synthase	ISS	22462730	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000008867|UniProtKB=H2QCF3	Mitogen-activated protein kinase	ISS	15085193	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00034	Integrin signalling pathway	P00948	Rho	CAEBR|Gene=CBG13664|UniProtKB=A8XIF5	Protein CBR-RHO-1	ISS	7798239	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00006	Apoptosis signaling pathway	P00260	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01143	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00004	Alzheimer disease-presenilin pathway	P00134	Nectin 1alpha transmembrane fragment	RAT|RGD=620791|UniProtKB=F1LNP8	Poliovirus receptor-related 1	ISS	12376527	PubMed	PTHR23277:SF69	NECTIN-1
P00048	PI3 kinase pathway	G01545	scl-1	CAEEL|WormBase=WBGene00019178|UniProtKB=Q9N5N3	SCP-Like extracellular protein	ISS			PTHR10334:SF254	SCP-LIKE EXTRACELLULAR PROTEIN
P00057	Wnt signaling pathway	P01448	CBP	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00010	B cell activation	P00373	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06786	ERK1/2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	RCA	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01465	Ggamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00053	T cell activation	P01295	vav	MACMU|Ensembl=ENSMMUG00000017214|UniProtKB=F7HEA0	Uncharacterized protein	ISS	14623913	PubMed	PTHR22826:SF95	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MACMU|Ensembl=ENSMMUG00000022577|UniProtKB=Q866A2	Neuronal acetylcholine receptor subunit alpha-7	ISS			PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P00057	Wnt signaling pathway	P01434	sFRP	MACMU|Ensembl=ENSMMUG00000019082|UniProtKB=F6SGW3	Secreted frizzled-related protein 1	ISS	9096311	PubMed	PTHR11309:SF87	SECRETED FRIZZLED-RELATED PROTEIN 1
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00001	Adrenaline and noradrenaline biosynthesis	P00066	DOPA decarb.	ARATH|TAIR=AT4G28680|UniProtKB=Q9M0G4	Probable tyrosine decarboxylase 2	ISS			PTHR11999:SF70	MIP05841P
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00036	Interleukin signaling pathway	P00976	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	PANTR|Gene=HTR1E|UniProtKB=Q9N2B6	5-hydroxytryptamine receptor 1E (Fragment)	ISS	12181435	PubMed	PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P00036	Interleukin signaling pathway	P00996	STAT	MONDO|Ensembl=ENSMODG00000011767|UniProtKB=F7CW94	Signal transducer and activator of transcription	ISS	12496413	PubMed	PTHR11801:SF19	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 4
P00034	Integrin signalling pathway	P00931	Integrin beta	RAT|RGD=1305581|UniProtKB=B2RYB8	Integrin beta	ISS	3487386	PubMed	PTHR10082:SF15	INTEGRIN BETA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	MONDO|Ensembl=ENSMODG00000004410|UniProtKB=F6SV58	Uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF322	SUBFAMILY NOT NAMED
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00059	p53 pathway	P01486	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00053	T cell activation	P01294	NFAT	PANTR|Ensembl=ENSPTRG00000006218|UniProtKB=H2Q834	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00218	STAT1	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00053	T cell activation	P01318	PKC-theta	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IGI	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04542	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04395	Vasopressin synthesis	P04590	Vasopressin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00017	DNA replication	P00533	Pol delta	MOUSE|MGI=MGI=97741|UniProtKB=P52431	DNA polymerase delta catalytic subunit	ISS	9620226	PubMed	PTHR10322:SF23	DNA POLYMERASE DELTA CATALYTIC SUBUNIT
P00019	Endothelin signaling pathway	P00577	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00648	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05913	Enkephalin release	P05978	AC	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	ARATH|TAIR=AT1G13890|UniProtKB=Q9LMG8	Putative SNAP25 homologous protein SNAP30	IC			PTHR19305:SF7	SNAP25 HOMOLOGOUS PROTEIN SNAP30-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	TAKRU|Ensembl=ENSTRUG00000003589|UniProtKB=H2S7P7	Uncharacterized protein	IDA			PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P02738	De novo purine biosynthesis	P02907	dADP kinase	CHLTR|EnsemblGenome=CT_500|UniProtKB=O84508	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05940	GRK5	PANTR|Ensembl=ENSPTRG00000002993|UniProtKB=H2Q2N7	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF27	G PROTEIN-COUPLED RECEPTOR KINASE 5
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00047	PDGF signaling pathway	P01153	GSK3	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05913	Enkephalin release	P05972	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176910	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00057	Wnt signaling pathway	P01451	Galpha	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00029	Huntington disease	P00779	TBP	MACMU|Ensembl=ENSMMUG00000019917|UniProtKB=F6SEF6	Uncharacterized protein	ISS	600075	OMIM	PTHR10126:SF20	TATA-BOX-BINDING PROTEIN
P00034	Integrin signalling pathway	P00924	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	RAT|RGD=1311791|UniProtKB=Q4KLF8	Actin-related protein 2/3 complex subunit 5	ISS	12473693	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=1308343|UniProtKB=D3ZFQ5	Protein Cdh9	ISS	8120095	PubMed	PTHR24027:SF99	CADHERIN-9
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000028559|UniProtKB=Q5DRD9	Protocadherin beta-10	ISS	8120095	PubMed	PTHR24028:SF54	PROTOCADHERIN BETA-10
P02731	Biotin biosynthesis	P02858	8-Amino-7-oxononanoate synthase	CHLTR|EnsemblGenome=CT_777|UniProtKB=O84782	8-amino-7-oxononanoate synthase	ISS			PTHR13693:SF77	8-AMINO-7-OXONONANOATE SYNTHASE
P00017	DNA replication	P00527	Histones	CAEBR|Gene=CBG16863|UniProtKB=A8XPY9	Histone H3	ISS	12413958	PubMed	PTHR11426:SF20	HISTONE H3-LIKE CENTROMERIC PROTEIN A
P00036	Interleukin signaling pathway	P00990	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00552	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	HUMAN|HGNC=7162|UniProtKB=P51512	Matrix metalloproteinase-16	TAS	12834808	PubMed	PTHR10201:SF26	MATRIX METALLOPROTEINASE-16
P00049	Parkinson disease	P01230	Src kinase	XENTR|Xenbase=XB-GENE-495082|UniProtKB=Q640S9	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF90	TYROSINE-PROTEIN KINASE YES
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00035	Interferon-gamma signaling pathway	P00960	PTP	RAT|RGD=3447|UniProtKB=P41499	Tyrosine-protein phosphatase non-receptor type 11	TAS	14525967	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CIOIN|Ensembl=ENSCING00000000407|UniProtKB=Q9U6V0	Protein Wnt	TAS	8717036	PubMed	PTHR12027:SF77	PROTEIN WNT-5
P00006	Apoptosis signaling pathway	P00304	XIAP	CHICK|Ensembl=ENSGALG00000008491|UniProtKB=Q8UVF8	Inhibitor of apoptosis protein 3	ISS			PTHR10044:SF115	BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 8-RELATED
P00053	T cell activation	P01324	rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=3763|UniProtKB=P30680	Somatostatin receptor type 2	IDA	12562507	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P05734	Synaptic vesicle trafficking	P05774	NSF	XENTR|Ensembl=ENSXETG00000031364|UniProtKB=F6PIV9	Uncharacterized protein	ISS	601633	OMIM	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00059	p53 pathway	P01486	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	CHICK|Gene=PSEN2|UniProtKB=Q90X07	Presenilin-2	TAS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00006	Apoptosis signaling pathway	P00321	HSP70	CANLF|Ensembl=ENSCAFG00000020196|UniProtKB=F1PIC7	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00049	Parkinson disease	P01238	14-3-3	MONDO|Ensembl=ENSMODG00000015951|UniProtKB=F7FRT9	Uncharacterized protein	ISS	12861023	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00059	p53 pathway	P04623	CBP	MACMU|Ensembl=ENSMMUG00000000893|UniProtKB=F6T7D0	Histone acetyltransferase p300	ISS	10769018	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00018	EGF receptor signaling pathway	P00547	PP2A	CHICK|Ensembl=ENSGALG00000009828|UniProtKB=E1C5A3	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00637	MKK4,7	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04398	p53 pathway feedback loops 2	G04714	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00018	EGF receptor signaling pathway	P00543	ERK1-2	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00944	Actin	BOVIN|Gene=ACTB|UniProtKB=P60712	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	RAT|RGD=2959|UniProtKB=P48550	G protein-activated inward rectifier potassium channel 2	IDA			PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01219	SAPK	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	NAS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01284	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	MOUSE|MGI=MGI=98878|UniProtKB=P07607	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00037	Ionotropic glutamate receptor pathway	P01026	KA	CHICK|Ensembl=ENSGALG00000015434|UniProtKB=F1NU20	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00047	PDGF signaling pathway	P01173	STAT	PANTR|Ensembl=ENSPTRG00000009199|UniProtKB=H2QD19	Signal transducer and activator of transcription	ISS	8732682	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00007	Axon guidance mediated by semaphorins	P00337	Sema3A	BOVIN|Ensembl=ENSBTAG00000018133|UniProtKB=F1MEW1	Uncharacterized protein	ISS	8402908	PubMed	PTHR11036:SF23	SEMAPHORIN-3A
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00047	PDGF signaling pathway	P01168	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04548	ATF2	CHICK|Ensembl=ENSGALG00000009287|UniProtKB=O93602	Cyclic AMP-dependent transcription factor ATF-2	IDA	10664585	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00005	Angiogenesis	P00190	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	20908895	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P02776	Serine glycine biosynthesis	P03160	Phosphoglycerate dehydrogenase	HALSA|EnsemblGenome=VNG_0104G|UniProtKB=Q9HSS1	Phosphoglycerate dehydrogenase	ISS			PTHR42938:SF9	FORMATE DEHYDROGENASE 1-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	RAT|RGD=70513|UniProtKB=P30969	Gonadotropin-releasing hormone receptor	IDA	12629106	PubMed	PTHR24241:SF22	GONADOTROPIN-RELEASING HORMONE RECEPTOR
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00006	Apoptosis signaling pathway	P00259	TNF	RAT|RGD=3876|UniProtKB=P16599	Tumor necrosis factor	ISS	11911478	PubMed	PTHR11471:SF23	TUMOR NECROSIS FACTOR
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	PANTR|Ensembl=ENSPTRG00000003543|UniProtKB=H2Q3H4	Uncharacterized protein	ISS	123810	OMIM	PTHR22952:SF24	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05731	GABA-B receptor II signaling	P05755	Gbeta	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	DICDI|dictyBase=DDB_G0292998|UniProtKB=P32252	Ras-like protein rasB	ISS	7997267	PubMed	PTHR24070:SF206	RAS-LIKE PROTEIN RASB
P00021	FGF signaling pathway	P00644	p38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IGI	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00008	Axon guidance mediated by Slit/Robo	P00355	Rho	CAEEL|WormBase=WBGene00004357|UniProtKB=Q22038	Ras-like GTP-binding protein rhoA	ISS	7798239	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00053	T cell activation	P01336	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02743	Formyltetrahydroformate biosynthesis	P02953	Cobalamin dependent homocysteine transmethylase	STRCO|Gene=CAC18788|UniProtKB=Q9EWH3	Putative methionine synthase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00029	Huntington disease	P00796	Kainate receptor	PANTR|Ensembl=ENSPTRG00000018449|UniProtKB=H2QTG5	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00054	Toll receptor signaling pathway	P01345	IKKalpha	MACMU|Ensembl=ENSMMUG00000018476|UniProtKB=F6X938	Uncharacterized protein	ISS	9346484	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00556	PLCgamma	DICDI|dictyBase=DDB_G0292736|UniProtKB=Q02158	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	IC			PTHR10336:SF105	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE
P00005	Angiogenesis	P00223	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CHICK|Ensembl=ENSGALG00000001172|UniProtKB=P19439	Probable glutamate receptor	IC	12941441	PubMed	PTHR18966:SF282	GLUTAMATE RECEPTOR-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00021	FGF signaling pathway	P00642	MEK1-2	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	BOVIN|Gene=CACNB1|UniProtKB=Q9MZL7	Voltage-dependent L-type calcium channel subunit beta-1	ISS	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00539	14-3-3	SCHMA|EnsemblGenome=Smp_002410|UniProtKB=Q95W36	14-3-3 epsilon 2	IGI	22057984	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	PANTR|Ensembl=ENSPTRG00000004718|UniProtKB=H2Q5I0	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00025	Hedgehog signaling pathway	P00682	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02769	Purine metabolism	P03119	5'-Nucleotidase	MACMU|Ensembl=ENSMMUG00000005442|UniProtKB=F7GPZ7	Uncharacterized protein	ISS	8224905	PubMed	PTHR11575:SF25	5'-NUCLEOTIDASE
P00005	Angiogenesis	P00217	STAT3	BOVIN|Gene=STAT3|UniProtKB=P61635	Signal transducer and activator of transcription 3	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00046	Oxidative stress response	P01121	MKK3/6	MONDO|Ensembl=ENSMODG00000001404|UniProtKB=F7BD74	Uncharacterized protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00046	Oxidative stress response	P01132	c-jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00011	Blood coagulation	P00434	FXIa	PANTR|Gene=F9|UniProtKB=Q95ND7	Coagulation factor IX	ISS	14270123	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P00006	Apoptosis signaling pathway	P00292	IkappaB	MACMU|Ensembl=ENSMMUG00000020374|UniProtKB=F6UMS2	NF-kappa-B inhibitor alpha	ISS	10811867	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00021	FGF signaling pathway	P00644	p38	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	IGI	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P06664	Gonadotropin-releasing hormone receptor pathway	P06834	MAP3Ks	MOUSE|MGI=MGI=1346877|UniProtKB=Q62073	Mitogen-activated protein kinase kinase kinase 7	RCA	10683140	PubMed	PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CAEEL|WormBase=WBGene00006538|UniProtKB=P41937	Tubulin beta-4 chain	ISS	12932731	PubMed	PTHR11588:SF89	TUBULIN BETA-4 CHAIN
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	TAKRU|Ensembl=ENSTRUG00000011517|UniProtKB=H2TWL9	Uncharacterized protein (Fragment)	ISS	12497607	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	1504106	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00046	Oxidative stress response	P01135	p38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	TAS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00019	Endothelin signaling pathway	P00570	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	IC	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	CANLF|Gene=MYC|UniProtKB=Q28350	Myc proto-oncogene protein	IEP	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00005	Angiogenesis	P00217	STAT3	BOVIN|Gene=STAT3|UniProtKB=P61635	Signal transducer and activator of transcription 3	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00059	p53 pathway	G04694	p110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00383	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00057	Wnt signaling pathway	P01465	Ggamma	TAKRU|Ensembl=ENSTRUG00000007253|UniProtKB=H2SZQ1	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00021	FGF signaling pathway	P00641	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00034	Integrin signalling pathway	P00948	Rho	XENTR|Xenbase=XB-GENE-495412|UniProtKB=Q6DJ10	Rho family GTPase 3	ISS	11973360	PubMed	PTHR24072:SF24	RHO-RELATED GTP-BINDING PROTEIN RHOE
P00049	Parkinson disease	P01219	SAPK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008422|UniProtKB=F6VUT7	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05913	Enkephalin release	P05972	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	SULSO|EnsemblGenome=SSO0640|UniProtKB=Q59968	Carbamoyl-phosphate synthase small chain	ISS			PTHR11405:SF4	CARBAMOYL-PHOSPHATE SYNTHASE ARGININE-SPECIFIC SMALL CHAIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CAEEL|WormBase=WBGene00000064|UniProtKB=P10984	Actin-2	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00021	FGF signaling pathway	P00638	PLCgamma	DROME|FlyBase=FBgn0003416|UniProtKB=Q9VXH3	Phosphoinositide phospholipase C	ISS			PTHR10336:SF91	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00005	Angiogenesis	P00219	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	BOVIN|Ensembl=ENSBTAG00000040199|UniProtKB=F2Z4H3	Uncharacterized protein	ISS	606023	OMIM	PTHR10917:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3
P05730	Endogenous cannabinoid signaling	P05751	Galpha	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CANLF|Ensembl=ENSCAFG00000009203|UniProtKB=F1PVZ1	Muscarinic acetylcholine receptor	ISS	10069496	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00035	Interferon-gamma signaling pathway	P00958	PIAS	PANTR|Ensembl=ENSPTRG00000009998|UniProtKB=H2QEH6	Uncharacterized protein	ISS	8682149	PubMed	PTHR10782:SF12	E3 SUMO-PROTEIN LIGASE PIAS2
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01082	AC	PANTR|Ensembl=ENSPTRG00000001638|UniProtKB=H2Q0J3	Adenylate cyclase type 10	ISS	10915626	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	TAS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	TRIAD|EnsemblGenome=TriadG63380|UniProtKB=B3S653	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	TAS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	LEIMA|EnsemblGenome=LmjF.18.1080|UniProtKB=Q27687	Protein kinase A catalytic subunit	IC	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00034	Integrin signalling pathway	P00931	Integrin beta	MACMU|Ensembl=ENSMMUG00000003289|UniProtKB=F7FG54	Integrin beta	ISS	124968	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00036	Interleukin signaling pathway	P00990	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	CANLF|Ensembl=ENSCAFG00000003197|UniProtKB=E2QXY7	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00948	Rho	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	IGI	15668138	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00008	Axon guidance mediated by Slit/Robo	P00344	Netrin	DANRE|ZFIN=ZDB-GENE-990415-169|UniProtKB=O42140	Netrin-1a	ISS	9427245	PubMed	PTHR10574:SF366	NETRIN-1A
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00034	Integrin signalling pathway	P00916	Ras	DICDI|dictyBase=DDB_G0292998|UniProtKB=P32252	Ras-like protein rasB	IPI	93205383	PubMed	PTHR24070:SF206	RAS-LIKE PROTEIN RASB
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02756	N-acetylglucosamine metabolism	P03043	N-acetylglucosamine-1-phosphate uridyltransferase	SYNY3|EnsemblGenome=BAA10856|UniProtKB=Q55504	Bifunctional protein GlmU	ISS			PTHR43584:SF3	BIFUNCTIONAL PROTEIN GLMU
P04393	Ras Pathway	P04542	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00780	Microtubule	SCHMA|EnsemblGenome=Smp_078040|UniProtKB=C4QIC0	Tubulin beta chain,putative	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P02723	Adenine and hypoxanthine salvage pathway	P02804	Hypoxanthine phosphoribosyl transferase	PANTR|Ensembl=ENSPTRG00000002366|UniProtKB=H2R333	Phosphoribosyl transferase domain containing 1	ISS			PTHR43340:SF5	PHOSPHORIBOSYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1
P00056	VEGF signaling pathway	P01408	Akt/PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00640	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IGI	10799299	PubMed	PTHR10048:SF14	PI-3 KINASE
P00052	TGF-beta signaling pathway	P01275	P38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00034	Integrin signalling pathway	P00919	Arf6	MOUSE|MGI=MGI=99435|UniProtKB=P62331	ADP-ribosylation factor 6	ISS	11752622	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	TAKRU|Ensembl=ENSTRUG00000018238|UniProtKB=H2VBT9	Uncharacterized protein	ISS			PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P05916	Opioid prodynorphin pathway	P06002	G-protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	ISS	15860573	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00054	Toll receptor signaling pathway	P01341	Elk1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	ISS	3183861	gi	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	HALSA|EnsemblGenome=AAC82822|UniProtKB=Q48325	TATA-box-binding protein B	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MOUSE|MGI=MGI=1346875|UniProtKB=O08648	Mitogen-activated protein kinase kinase kinase 4	IGI	97236778	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00059	p53 pathway	P04626	GADD45	PANTR|Ensembl=ENSPTRG00000021095|UniProtKB=H2QXF6	Growth arrest and DNA-damage-inducible, gamma	ISS	10097101	PubMed	PTHR10411:SF4	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 GAMMA
P00010	B cell activation	P00402	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	TAS	12655147	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05913	Enkephalin release	P05974	G-Protein (i)	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	HUMAN|HGNC=10635|UniProtKB=P80075	C-C motif chemokine 8	ISS			PTHR12015:SF144	C-C MOTIF CHEMOKINE 8
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01154	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00048	PI3 kinase pathway	P01188	Gbetagamma	DROME|FlyBase=FBgn0030011|UniProtKB=Q9W3J1	Gbeta5	IC	11313908	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g195622|UniProtKB=A7T2Q5	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00547	PP2A	ORYSJ|EnsemblGenome=OS03G0844500|UniProtKB=Q75LC7	Os03g0844500 protein	ISS			PTHR10257:SF46	SERINE/THREONINE PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B' DELTA ISOFORM-RELATED
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	MACMU|Ensembl=ENSMMUG00000023256|UniProtKB=F7HPX5	Uncharacterized protein	ISS	9039917	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	RAT|RGD=2740|UniProtKB=Q62645	Glutamate receptor ionotropic, NMDA 2D	ISS	14698601	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P06664	Gonadotropin-releasing hormone receptor pathway	P06847	JNK1/2	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	RCA	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00018	EGF receptor signaling pathway	P00561	STAT	MOUSE|MGI=MGI=103034|UniProtKB=P52633	Signal transducer and transcription activator 6	IGI	14598258	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	8170357	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	ARATH|TAIR=AT1G04440|UniProtKB=Q5XF24	At1g04440	IDA	10617630	PubMed	PTHR11909:SF178	CASEIN KINASE 1-LIKE PROTEIN 8
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	10218114	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CANLF|Ensembl=ENSCAFG00000013179|UniProtKB=E2RPU9	Uncharacterized protein	ISS	11259498	PubMed	PTHR24229:SF11	NOCICEPTIN RECEPTOR
P00020	FAS signaling pathway	P00615	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	10218114	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00018	EGF receptor signaling pathway	P00559	MEK1-2	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	15210700	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04393	Ras Pathway	P04557	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00006	Apoptosis signaling pathway	P00326	FAS ligand	PANTR|Ensembl=ENSPTRG00000001690|UniProtKB=H2Q0M2	Uncharacterized protein	ISS	7528780	PubMed	PTHR11471:SF33	TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 6
P00002	Alpha adrenergic receptor signaling pathway	P00078	Alpha1A/1B/1C	MOUSE|MGI=MGI=104773|UniProtKB=P97718	Alpha-1A adrenergic receptor	IC	11781138	PubMed	PTHR24248:SF16	ALPHA-1A ADRENERGIC RECEPTOR
P00001	Adrenaline and noradrenaline biosynthesis	P00066	DOPA decarb.	DROME|FlyBase=FBgn0050446|UniProtKB=A1Z6N4	MIP05841p	ISS			PTHR11999:SF70	MIP05841P
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CAEEL|WormBase=WBGene00003774|UniProtKB=G5EGQ9	NMDA class glutamate Receptor	IC	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	RAT|RGD=67399|UniProtKB=Q64716	Insulin receptor-related protein	ISS	11182407	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	XENTR|Xenbase=XB-GENE-969601|UniProtKB=Q28H40	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P05913	Enkephalin release	P05974	G-Protein (i)	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2747|UniProtKB=P35349	Metabotropic glutamate receptor 6	IDA	12488551	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00034	Integrin signalling pathway	P00908	p130CAS	PANTR|Ensembl=ENSPTRG00000008357|UniProtKB=H2RDY8	Uncharacterized protein	ISS	8649368	PubMed	PTHR10654:SF15	BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 1
P00059	p53 pathway	G04694	p110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ANOGA|EnsemblGenome=AGAP001676|UniProtKB=Q7PXZ8	AGAP001676-PA	IC	11889126	PubMed	PTHR11937:SF368	ACTIN, INDIRECT FLIGHT MUSCLE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00017	DNA replication	P00527	Histones	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g227757|UniProtKB=A7TAJ3	Histone H3	ISS	12413958	PubMed	PTHR11426:SF20	HISTONE H3-LIKE CENTROMERIC PROTEIN A
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04393	Ras Pathway	P04550	Ral	BOVIN|Ensembl=ENSBTAG00000032021|UniProtKB=A5D977	RALB protein	ISS	11025226	PubMed	PTHR24070:SF199	RAS-RELATED PROTEIN RAL-B
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00205	GAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	20908895	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00005	Angiogenesis	P00243	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00006	Apoptosis signaling pathway	P00257	Bcl-xL	RAT|RGD=2200|UniProtKB=P53563	Bcl-2-like protein 1	ISS	10365962	PubMed	PTHR11256:SF12	BCL-2-LIKE PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	RAT|RGD=3100|UniProtKB=P50280	Matrilysin	TAS	12356903	PubMed	PTHR10201:SF143	MATRILYSIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g242065|UniProtKB=A7S0V7	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00029	Huntington disease	P00807	Actin	PUCGT|EnsemblGenome=PGTG_05488|UniProtKB=E3K4I1	Actin	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=19663|UniProtKB=Q9UBI6	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01215	Syntaxin	ARATH|TAIR=AT1G32270|UniProtKB=Q9C615	Putative syntaxin-24	IPI			PTHR19957:SF38	T-SNARE DOMAIN-CONTAINING PROTEIN 1
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	ORNAN|Ensembl=ENSOANG00000004801|UniProtKB=F7FFC7	Uncharacterized protein	ISS			PTHR11699:SF233	ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL
P00059	p53 pathway	P01485	p53	BOVIN|Ensembl=ENSBTAG00000015460|UniProtKB=F1MKA9	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P05913	Enkephalin release	G06045	preproenkephalin	MACMU|Ensembl=ENSMMUG00000006775|UniProtKB=F7H3N8	Uncharacterized protein	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00643	Raf-1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01143	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00562	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00036	Interleukin signaling pathway	P00976	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00047	PDGF signaling pathway	P01154	Ras	DICDI|dictyBase=DDB_G0292998|UniProtKB=P32252	Ras-like protein rasB	ISS	7997267	PubMed	PTHR24070:SF206	RAS-LIKE PROTEIN RASB
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IDA	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	CANLF|Ensembl=ENSCAFG00000018170|UniProtKB=E2RPM8	Tyrosine-protein kinase receptor	ISS	2983222	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P04398	p53 pathway feedback loops 2	P04653	cdk2	HUMAN|HGNC=1771|UniProtKB=P24941	Cyclin-dependent kinase 2	ISS	1846803	PubMed	PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	HUMAN|HGNC=7567|UniProtKB=P12882	Myosin-1	ISS	10938134	PubMed	PTHR13140:SF484	MYOSIN-1
P00059	p53 pathway	G04694	p110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	IDA	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00047	PDGF signaling pathway	P01143	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01451	Galpha	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01432	Beta-Catenin	ORNAN|Ensembl=ENSOANG00000006811|UniProtKB=F6WBD5	Uncharacterized protein	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P05917	Opioid proopiomelanocortin pathway	P06010	proopiomelanocortin	BOVIN|Ensembl=ENSBTAG00000007897|UniProtKB=P01190	Pro-opiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00056	VEGF signaling pathway	P01425	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00014	Cholesterol biosynthesis	P00490	Dimethylallyl trans-transferase	MACMU|Ensembl=ENSMMUG00000007145|UniProtKB=F7DMS6	Geranylgeranyl pyrophosphate synthase	RCA			PTHR12001:SF44	GERANYLGERANYL PYROPHOSPHATE SYNTHASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00590	IP3 R	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	IGI	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00019	Endothelin signaling pathway	P00590	IP3 R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00056	VEGF signaling pathway	P01421	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	RCA			PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00018	EGF receptor signaling pathway	P00542	EGFR	CHICK|Ensembl=ENSGALG00000003126|UniProtKB=F1P258	Receptor protein-tyrosine kinase	ISS	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	PANTR|Ensembl=ENSPTRG00000021182|UniProtKB=H2QXK2	Receptor protein serine/threonine kinase	ISS	10683140	PubMed	PTHR23255:SF61	TGF-BETA RECEPTOR TYPE-1
P00005	Angiogenesis	P00244	MAPKAPK2/3	PANTR|Ensembl=ENSPTRG00000001915|UniProtKB=H2Q104	Mitogen-activated protein kinase-activated protein kinase 2	ISS	9628873	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P04393	Ras Pathway	P04558	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	IDA	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00019	Endothelin signaling pathway	P00568	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	DICDI|dictyBase=DDB_G0284329|UniProtKB=Q54PQ4	Ras guanine nucleotide exchange factor A	ISS			PTHR23113:SF236	RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR A
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IGI	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	DROME|FlyBase=FBgn0264000|UniProtKB=M9PHV5	Glutamate receptor IB, isoform B	IC	8804111	PubMed	PTHR18966:SF270	GLUTAMATE RECEPTOR 1-RELATED
P06211	BMP/activin signaling pathway-drosophila	P06247	PPM1A	DROME|FlyBase=FBgn0086361|UniProtKB=Q961C5	Alphabet, isoform E	IEA	http://flybase.org/reports/FBgn0086361.html	Website	PTHR13832:SF524	PROTEIN PHOSPHATASE 1A, MAGNESIUM DEPENDENT, ALPHA ISOFORM-RELATED
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05918	p38 MAPK pathway	P06026	MEKK4	BOVIN|Ensembl=ENSBTAG00000020079|UniProtKB=F1N3T0	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P04393	Ras Pathway	P04555	PDK	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	15531926	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P02762	Pentose phosphate pathway	P03080	Glucose-P-Isomerase	CHLTR|EnsemblGenome=CT_378|UniProtKB=P0CD72	Glucose-6-phosphate isomerase	IEA	9784136	PubMed	PTHR11469:SF1	GLUCOSE-6-PHOSPHATE ISOMERASE, CYTOSOLIC
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IDA	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00049	Parkinson disease	P01213	Cyclin E	CHICK|Gene=CCNE1|UniProtKB=P49707	G1/S-specific cyclin-E1	IDA	12628165	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00562	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	IDA	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00059	p53 pathway	G04703	Apaf	PANTR|Ensembl=ENSPTRG00000005335|UniProtKB=H2R1S6	Apoptotic protease-activating factor 1	ISS	10364241	PubMed	PTHR22845:SF5	APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	TAS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	IDA	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=620749|UniProtKB=Q767H7	Cadherin-related neuronal receptor c2	ISS	8120095	PubMed	PTHR24028:SF119	PROTOCADHERIN ALPHA-C2
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00623	FGF	XENTR|Xenbase=XB-GENE-483674|UniProtKB=B7U3Y1	Fibroblast growth factor	ISS	8790420	PubMed	PTHR11486:SF18	FIBROBLAST GROWTH FACTOR 14
P00059	p53 pathway	G01569	Maspin	PANTR|Ensembl=ENSPTRG00000029287|UniProtKB=H2R6Q3	Uncharacterized protein	ISS	10692390	PubMed	PTHR11461:SF55	SERPIN B5
P00053	T cell activation	P01312	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IDA	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00008	Axon guidance mediated by Slit/Robo	P00355	Rho	BOVIN|Ensembl=ENSBTAG00000014299|UniProtKB=Q1RMJ6	Rho-related GTP-binding protein RhoC	ISS	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P02776	Serine glycine biosynthesis	P03157	Phosphoserine aminotransferase	BOVIN|Ensembl=ENSBTAG00000013960|UniProtKB=A6QR28	Phosphoserine aminotransferase	ISS	2682527	PubMed	PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PANTR|Ensembl=ENSPTRG00000023453|UniProtKB=H2R002	Myosin IB	ISS			PTHR13140:SF277	UNCONVENTIONAL MYOSIN-IB
P00056	VEGF signaling pathway	P01417	Raf	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00059	p53 pathway	P04609	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06587	Nicotine pharmacodynamics pathway	P06601	FLNA	MOUSE|MGI=MGI=95556|UniProtKB=Q8BTM8	Filamin-A	RCA	11911837	PubMed	PTHR43998:SF6	FILAMIN-A
P00021	FGF signaling pathway	P00629	PP2A	ARATH|TAIR=AT2G42500|UniProtKB=Q07100	Serine/threonine-protein phosphatase PP2A-4 catalytic subunit	ISS			PTHR11668:SF318	SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-4 CATALYTIC SUBUNIT
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05939	GRK6	CANLF|Ensembl=ENSCAFG00000016388|UniProtKB=F6X9W7	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P00056	VEGF signaling pathway	P01407	Erk	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01435	SWI/SNF	CHICK|Ensembl=ENSGALG00000010164|UniProtKB=E1C2F7	Uncharacterized protein	IDA	11532957	PubMed	PTHR10799:SF541	GLOBAL TRANSCRIPTION ACTIVATOR SNF2L2-RELATED
P00029	Huntington disease	P00797	p53	CANLF|Ensembl=ENSCAFG00000009720|UniProtKB=F1PDQ4	Uncharacterized protein	ISS			PTHR12195:SF2	CYTOPLASMIC FMR1-INTERACTING PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MOUSE|MGI=MGI=97011|UniProtKB=P41245	Matrix metalloproteinase-9	TAS	12834808	PubMed	PTHR10201:SF30	MATRIX METALLOPROTEINASE-9
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00715	AGS3	CANLF|Ensembl=ENSCAFG00000019694|UniProtKB=E2R0Q9	Uncharacterized protein	ISS	11121039	PubMed	PTHR10098:SF36	G-PROTEIN-SIGNALING MODULATOR 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-990415-257|UniProtKB=O42376	Mitogen-activated protein kinase 12	TAS	11707292	PubMed	PTHR24055:SF339	MITOGEN-ACTIVATED PROTEIN KINASE 12
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00046	Oxidative stress response	P01135	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	TAS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CAEEL|WormBase=WBGene00001187|UniProtKB=Q8MQA1	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	20264070	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00057	Wnt signaling pathway	P01451	Galpha	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00012	Cadherin signaling pathway	P00470	F-actin	HUMAN|HGNC=129|UniProtKB=P68133	Actin, alpha skeletal muscle	IC	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DROME|FlyBase=FBgn0000046|UniProtKB=P10981	Actin-87E	ISS	10974003	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00010	B cell activation	P00375	Calmodulin	BRAFL|Gene=BRAFLDRAFT_59748|UniProtKB=C3ZEW2	Putative uncharacterized protein	ISS			PTHR23050:SF263	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00049	Parkinson disease	P01227	20S proteasome	MOUSE|MGI=MGI=1347005|UniProtKB=Q9R1P4	Proteasome subunit alpha type-1	ISS	12859888	PubMed	PTHR11599:SF12	PROTEASOME SUBUNIT ALPHA TYPE-RELATED
P00053	T cell activation	P01320	PLC-gamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00006	Apoptosis signaling pathway	P00260	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01148	Grb2	CHICK|Gene=GRB2|UniProtKB=Q07883	Growth factor receptor-bound protein 2	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00010	B cell activation	P00384	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00058	mRNA splicing	P01476	U4	CAEEL|WormBase=WBGene00007972|UniProtKB=Q93339	Yeast PRP (Splicing factor) related	ISS	11099033	PubMed	PTHR19846:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP4
P00029	Huntington disease	P00807	Actin	MACMU|Ensembl=ENSMMUG00000017683|UniProtKB=F6UA63	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00030	Hypoxia response via HIF activation	P00819	AKT	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	TAS	12655147	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06009	K+ channel	MONDO|Ensembl=ENSMODG00000015769|UniProtKB=F6ZSC2	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00053	T cell activation	P01300	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00254	GTPase	BOVIN|Ensembl=ENSBTAG00000046054|UniProtKB=Q3ZBW5	Rho-related GTP-binding protein RhoB	ISS	11973360	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00318	PKCs	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01082	AC	PANTR|Ensembl=ENSPTRG00000001638|UniProtKB=H2Q0J3	Adenylate cyclase type 10	ISS	11744988	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01305	Calmodulin	CAEBR|Gene=CBG01097|UniProtKB=A8WPJ8	Protein CBR-CMD-1	ISS			PTHR23050:SF236	CALMODULIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	TAS			PTHR10048:SF14	PI-3 KINASE
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	BRADU|Gene=BAC52719|UniProtKB=Q89DI5	Pyrroline-5-carboxylate reductase	ISS			PTHR11645:SF0	PYRROLINE-5-CARBOXYLATE REDUCTASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01286	TGFbeta	ORNAN|Ensembl=ENSOANG00000010700|UniProtKB=F6SCP7	Uncharacterized protein	ISS	9395284	PubMed	PTHR11848:SF133	INHIBIN BETA A CHAIN
P00017	DNA replication	P00527	Histones	MACMU|Ensembl=ENSMMUG00000032409|UniProtKB=F6UJL2	Histone H3	ISS	20448842	PubMed	PTHR11426:SF179	HISTONE H3.3
P00029	Huntington disease	P00786	ARF	DANRE|ZFIN=ZDB-GENE-010724-5|UniProtKB=Q803D1	ADP-ribosylation factor 1	ISS	11752622	PubMed	PTHR11711:SF294	ADP-RIBOSYLATION FACTOR 3
P00038	JAK/STAT signaling pathway	P01027	STAT	MOUSE|MGI=MGI=103035|UniProtKB=P42232	Signal transducer and activator of transcription 5B	ISS	14662325	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	BOVIN|Ensembl=ENSBTAG00000039151|UniProtKB=F6R5F6	Uncharacterized protein	ISS	1608964	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CANLF|Ensembl=ENSCAFG00000005662|UniProtKB=E2R907	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00030	Hypoxia response via HIF activation	P00819	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00013	Cell cycle	P00480	Proteasome	TRYB2|Gene=Tb10.61.0600|UniProtKB=Q387U2	Proteasome regulatory non-ATP-ase subunit 9	ISS	21975205	PubMed	PTHR10539:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	HUMAN|HGNC=8591|UniProtKB=Q13177	Serine/threonine-protein kinase PAK 2	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00047	PDGF signaling pathway	P01160	IP3 receptor	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00049	Parkinson disease	P01208	Hsp70	TRIVA|Gene=TVAG_300470|UniProtKB=A2EP28	Cytoplasmic heat shock protein 70, putative	IDA	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00049	Parkinson disease	P01229	Pael-R	MACMU|Ensembl=ENSMMUG00000013788|UniProtKB=F6TEF3	Endothelin B receptor-like protein 2	ISS			PTHR24243:SF33	PROSAPOSIN RECEPTOR GPR37L1
P00019	Endothelin signaling pathway	P00586	Gq	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	8920915	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00047	PDGF signaling pathway	P01161	Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	ISS	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P04393	Ras Pathway	P04565	MKK4/7	MONDO|Ensembl=ENSMODG00000008266|UniProtKB=F6Z879	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00021	FGF signaling pathway	P00624	14-3-3	CHICK|Ensembl=ENSGALG00000006743|UniProtKB=Q5ZKJ2	Uncharacterized protein	ISS	14593000	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00019	Endothelin signaling pathway	P00590	IP3 R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IGI	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00053	T cell activation	P01336	Jnk	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00048	PI3 kinase pathway	P01188	Gbetagamma	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IC	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00206	Wnt	HUMAN|HGNC=12787|UniProtKB=P56706	Protein Wnt-7b	ISS	11266476	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04398	p53 pathway feedback loops 2	P04657	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00036	Interleukin signaling pathway	P00973	PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04559	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IC	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00019	Endothelin signaling pathway	P00566	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	RAT|RGD=2246|UniProtKB=Q07652	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	14507926	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00036	Interleukin signaling pathway	P00983	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	HUMAN|HGNC=4584|UniProtKB=Q05586	Glutamate receptor ionotropic, NMDA 1	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	IC	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00059	p53 pathway	P04609	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	IC	11956331	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00019	Endothelin signaling pathway	P00577	PI3K	ANOGA|EnsemblGenome=AGAP011036|UniProtKB=A0NBA9	AGAP011036-PA (Fragment)	ISS	7937853	PubMed	PTHR10048:SF64	LD28067P
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CHICK|Ensembl=ENSGALG00000012894|UniProtKB=P30372	Muscarinic acetylcholine receptor M2	IDA	12181435	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00059	p53 pathway	G04690	PAG608	MACMU|Ensembl=ENSMMUG00000003216|UniProtKB=F7EAY3	Uncharacterized protein	ISS			PTHR23067:SF5	ZINC FINGER MATRIN-TYPE PROTEIN 3
P00053	T cell activation	P01294	NFAT	HUMAN|HGNC=7776|UniProtKB=Q13469	Nuclear factor of activated T-cells, cytoplasmic 2	IGI	12787506	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00053	T cell activation	P01304	Csk	CANLF|Ensembl=ENSCAFG00000017945|UniProtKB=E2RFF7	Tyrosine-protein kinase	ISS	12665526	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P04373	5HT1 type receptor mediated signaling pathway	P04409	5HT transporter	RAT|RGD=3714|UniProtKB=P31652	Sodium-dependent serotonin transporter	IEA	14653308	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P00045	Notch signaling pathway	P01113	Pen-2	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=109521|UniProtKB=P35363	5-hydroxytryptamine receptor 2A	IDA			PTHR24247:SF30	5-HYDROXYTRYPTAMINE RECEPTOR 2A
P00018	EGF receptor signaling pathway	P00545	JNK1-3	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS			PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	P01465	Ggamma	MOUSE|MGI=MGI=1336171|UniProtKB=Q9DAS9	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IDA	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	TAS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00036	Interleukin signaling pathway	P00973	PKB	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	RAT|RGD=3784|UniProtKB=P61265	Syntaxin-1B	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00019	Endothelin signaling pathway	P00583	cPLA2	PANTR|Ensembl=ENSPTRG00000001787|UniProtKB=H2Q0T0	Phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00018	EGF receptor signaling pathway	P00564	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	15470041	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00322	Cytochrome C	RAT|RGD=2451|UniProtKB=P62898	Cytochrome c, somatic	ISS	11836241	PubMed	PTHR11961:SF15	CYTOCHROME C
P00005	Angiogenesis	P00206	Wnt	DANRE|ZFIN=ZDB-GENE-081006-1|UniProtKB=F1Q9W3	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	TRIVA|Gene=TVAG_008680|UniProtKB=A2DC16	Beta-tubulin, putative	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00017	DNA replication	P00527	Histones	NEUCR|EnsemblGenome=EFNCRG00000001780|UniProtKB=P07041	Histone H3	ISS	12413958	PubMed	PTHR11426:SF169	HISTONE H3
P00015	Circadian clock system	G01497	cry	PANTR|Ensembl=ENSPTRG00000003537|UniProtKB=H2Q3H0	Uncharacterized protein	ISS	10428031	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00036	Interleukin signaling pathway	P00975	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	8262392	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00005	Angiogenesis	P00252	Grb2	DROME|FlyBase=FBgn0004638|UniProtKB=Q08012	Protein enhancer of sevenless 2B	ISS			PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MOUSE|MGI=MGI=1930780|UniProtKB=Q61879	Myosin-10	ISS	89264452	PubMed	PTHR13140:SF328	MYOSIN-10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000001583|UniProtKB=F7BBM1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	ARATH|TAIR=AT5G61210|UniProtKB=Q9S7P9	SNAP25 homologous protein SNAP33	IC			PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P05730	Endogenous cannabinoid signaling	P05751	Galpha	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00990	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	BOVIN|Gene=FURIN|UniProtKB=Q28193	Furin	IDA	11861638	PubMed	PTHR42884:SF1	FURIN
P00006	Apoptosis signaling pathway	P00274	JNK	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	ISS	12040174	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P05918	p38 MAPK pathway	P06043	ASK1	BOVIN|Ensembl=ENSBTAG00000009065|UniProtKB=F1MXH6	Uncharacterized protein	ISS	12697749	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00013	Cell cycle	P00480	Proteasome	YEAST|SGD=S000000823|UniProtKB=P40016	26S proteasome regulatory subunit RPN3	IGI	97170075	PubMed	PTHR10758:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3
P06215	MYO signaling pathway	P06318	FUR1	DROME|FlyBase=FBgn0004509|UniProtKB=P26016	Furin-like protease 1, isoforms 1/1-X/2	IEA	10956649	PubMed	PTHR42884:SF3	FURIN-LIKE PROTEASE 1, ISOFORMS 1/1-X/2
P00057	Wnt signaling pathway	P01438	PP2A	ORNAN|Ensembl=ENSOANG00000005732|UniProtKB=F6X0X1	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04393	Ras Pathway	P04566	Stat 1/3	HUMAN|HGNC=11362|UniProtKB=P42224	Signal transducer and activator of transcription 1-alpha/beta	IDA	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P04393	Ras Pathway	P04552	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IDA	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000013587|UniProtKB=F7AZ16	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF33	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-3
P00041	Metabotropic glutamate receptor group I pathway	P01062	mGluR1	HUMAN|HGNC=4597|UniProtKB=P41594	Metabotropic glutamate receptor 5	ISS			PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00010	B cell activation	P00391	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	HUMAN|HGNC=23720|UniProtKB=Q70SY1	Cyclic AMP-responsive element-binding protein 3-like protein 2	ISS	608972	OMIM	PTHR22952:SF96	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 2
P00045	Notch signaling pathway	P01107	Fringe	MOUSE|MGI=MGI=1095413|UniProtKB=O09010	Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe	IGI	12670869	PubMed	PTHR10811:SF7	BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE LUNATIC FRINGE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05913	Enkephalin release	P05974	G-Protein (i)	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	LEIMA|EnsemblGenome=LmjF.18.1080|UniProtKB=Q27687	Protein kinase A catalytic subunit	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00006	Apoptosis signaling pathway	P00302	ATF	HUMAN|HGNC=784|UniProtKB=P15336	Cyclic AMP-dependent transcription factor ATF-2	ISS	10664585	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00019	Endothelin signaling pathway	P00586	Gq	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01194	S6K	BOVIN|Ensembl=ENSBTAG00000009175|UniProtKB=E1BLQ5	Uncharacterized protein	ISS	15116068	PubMed	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00005	Angiogenesis	P00211	GSK3beta	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00049	Parkinson disease	P01216	Parkin	PANTR|Ensembl=ENSPTRG00000018781|UniProtKB=H2QU08	E3 ubiquitin-protein ligase parkin	ISS	11078524	PubMed	PTHR11685:SF214	E3 UBIQUITIN-PROTEIN LIGASE PARKIN
P00025	Hedgehog signaling pathway	P00683	Slimb	BOVIN|Ensembl=ENSBTAG00000015376|UniProtKB=F1MLG0	Uncharacterized protein	ISS	10074433	PubMed	PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8972|UniProtKB=O00750	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	IPI	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	IC	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=69279|UniProtKB=Q9R0T4	Cadherin-1	IDA	12834808	PubMed	PTHR24027:SF319	CADHERIN-1
P05918	p38 MAPK pathway	P06035	TAB1	MOUSE|MGI=MGI=1913763|UniProtKB=Q8CF89	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1	ISS	8638164	PubMed	PTHR13832:SF533	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04393	Ras Pathway	P04542	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05731	GABA-B receptor II signaling	P05760	AC	RAT|RGD=2035|UniProtKB=Q03343	Adenylate cyclase type 6	RCA	93028552	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IGI	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	MACMU|Ensembl=ENSMMUG00000021075|UniProtKB=F7GY91	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CHICK|Ensembl=ENSGALG00000012821|UniProtKB=P32882	Tubulin beta-2 chain	ISS	12932731	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	RAT|RGD=2734|UniProtKB=Q01812	Glutamate receptor ionotropic, kainate 4	ISS	1648176	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00839	SHIP	PANTR|Ensembl=ENSPTRG00000004031|UniProtKB=H2Q4C6	Inositol polyphosphate phosphatase-like 1	ISS	10610720	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	IDA	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00036	Interleukin signaling pathway	P00981	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MONDO|Ensembl=ENSMODG00000008826|UniProtKB=F6XUU0	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00577	PI3K	CAEEL|WormBase=WBGene00009552|UniProtKB=G5EDY0	Phosphatidylinositol 3-kinase piki-1	ISS	7937853	PubMed	PTHR10048:SF64	LD28067P
P00060	Ubiquitin proteasome pathway	P01491	E2	HUMAN|HGNC=12472|UniProtKB=P49459	Ubiquitin-conjugating enzyme E2 A	ISS			PTHR43898:SF4	UBIQUITIN-CONJUGATING ENZYME E2 A
P00048	PI3 kinase pathway	P01185	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000000323|UniProtKB=H2PYA3	Uncharacterized protein	ISS	11701344	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05913	Enkephalin release	P05974	G-Protein (i)	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00878	INFgamma	CANLF|Ensembl=ENSCAFG00000000408|UniProtKB=P42161	Interferon gamma	TAS	11929133	PubMed	PTHR11419:SF0	INTERFERON GAMMA
P02723	Adenine and hypoxanthine salvage pathway	P02810	Adenine phosphoribosyl transferase	SYNY3|EnsemblGenome=BAA18001|UniProtKB=P73935	Adenine phosphoribosyltransferase	ISS			PTHR32315:SF3	ADENINE PHOSPHORIBOSYLTRANSFERASE
P00018	EGF receptor signaling pathway	P00550	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	7689150	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00054	Toll receptor signaling pathway	P01358	ERK1	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00916	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	TAS	3045562	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P04393	Ras Pathway	P04566	Stat 1/3	PANTR|Ensembl=ENSPTRG00000009200|UniProtKB=H2QD20	Signal transducer and activator of transcription	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00322	Cytochrome C	CANLF|Ensembl=ENSCAFG00000002856|UniProtKB=P00011	Cytochrome c	ISS	5846985	PubMed	PTHR11961:SF15	CYTOCHROME C
P00048	PI3 kinase pathway	P01192	p110	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	RCA	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00006	Apoptosis signaling pathway	P00305	Caspase 3	MACMU|Ensembl=ENSMMUG00000012053|UniProtKB=F7HFY2	Uncharacterized protein	ISS	7983002	PubMed	PTHR10454:SF198	CASPASE-3
P00036	Interleukin signaling pathway	P00973	PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	MACMU|Ensembl=ENSMMUG00000001387|UniProtKB=F7D0B4	Uncharacterized protein	ISS	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00857	IkappaB	RAT|RGD=3171|UniProtKB=Q63746	NF-kappa-B inhibitor alpha	ISS	99081292	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00005	Angiogenesis	P00219	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P02728	Arginine biosynthesis	P02841	argininosuccinate lyase	PYRAE|EnsemblGenome=PAE2887|UniProtKB=Q8ZU95	Argininosuccinate lyase	ISS			PTHR43814:SF1	ARGININOSUCCINATE LYASE
P00010	B cell activation	P00402	Jnk	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05731	GABA-B receptor II signaling	P05756	GABA-B receptor	RAT|RGD=621537|UniProtKB=Q9Z0U4	Gamma-aminobutyric acid type B receptor subunit 1	TAS	9872315	PubMed	PTHR10519:SF42	GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 1
P00005	Angiogenesis	P00182	p38MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00053	T cell activation	P01333	cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00005	Angiogenesis	P00203	Erk	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	CAEEL|WormBase=WBGene00010436|UniProtKB=Q95QD6	Uncharacterized protein	ISS			PTHR11079:SF92	TRNA-SPECIFIC ADENOSINE DEAMINASE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	CHICK|Ensembl=ENSGALG00000017178|UniProtKB=F1N982	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01160	IP3 receptor	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06849	Sos	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	RCA	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04393	Ras Pathway	P04546	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00049	Parkinson disease	P01211	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	PANTR|Ensembl=ENSPTRG00000006510|UniProtKB=H2Q8K1	Presenilin	ISS	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00760	Gtalpha	PANTR|Ensembl=ENSPTRG00000014949|UniProtKB=H2QMN3	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF67	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MACMU|Ensembl=ENSMMUG00000009054|UniProtKB=F7F735	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00019	Endothelin signaling pathway	P00587	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00008	Axon guidance mediated by Slit/Robo	P00355	Rho	HUMAN|HGNC=669|UniProtKB=P08134	Rho-related GTP-binding protein RhoC	ISS	12090470	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P02755	Methylmalonyl pathway	P03034	Methylmalonyl-CoA mutase	STRCO|Gene=CAA22720|UniProtKB=Q9ZBK2	Coenzyme B12-dependent mutase	ISS			PTHR43589:SF3	SUBFAMILY NOT NAMED
P06959	CCKR signaling map	G07261	HBEGF	HUMAN|HGNC=3059|UniProtKB=Q99075	Proheparin-binding EGF-like growth factor	RCA	9869605	PubMed	PTHR10740:SF4	PROHEPARIN-BINDING EGF-LIKE GROWTH FACTOR
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	PANTR|Ensembl=ENSPTRG00000017238|UniProtKB=H2QRH7	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06788	TORC1	MOUSE|MGI=MGI=2142523|UniProtKB=Q68ED7	CREB-regulated transcription coactivator 1	RCA			PTHR13589:SF14	CREB-REGULATED TRANSCRIPTION COACTIVATOR 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-478663|UniProtKB=F7EG64	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=3026|UniProtKB=P21918	D(1B) dopamine receptor	IDA			PTHR43893:SF8	D 1B  DOPAMINE RECEPTOR
P06664	Gonadotropin-releasing hormone receptor pathway	P06836	PG Rcs	MOUSE|MGI=MGI=104311|UniProtKB=P32240	Prostaglandin E2 receptor EP4 subtype	RCA			PTHR11866:SF6	PROSTAGLANDIN E2 RECEPTOR EP4 SUBTYPE
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01428	Frizzled	ANOGA|EnsemblGenome=AGAP010442|UniProtKB=Q7QDV6	AGAP010442-PA	ISS	11212302	PubMed	PTHR11309:SF90	FRIZZLED-8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01189	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P05913	Enkephalin release	G06045	preproenkephalin	HUMAN|HGNC=8820|UniProtKB=P01213	Proenkephalin-B	IC	131330	OMIM	PTHR11438:SF4	PROENKEPHALIN-B
P04393	Ras Pathway	P04560	AP1	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00053	T cell activation	P01327	Gads	MACMU|Ensembl=ENSMMUG00000004880|UniProtKB=F7AN37	GRB2-related adapter protein 2	ISS	10021361	PubMed	PTHR24418:SF299	GRB2-RELATED ADAPTER PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	PANTR|Ensembl=ENSPTRG00000007810|UniProtKB=H2QAM8	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF335	MYOSIN-11
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000023202|UniProtKB=F7EU36	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	G01535	PIG3	XENTR|Xenbase=XB-GENE-941589|UniProtKB=F7CTI1	Uncharacterized protein	ISS	12932731	PubMed	PTHR44054:SF1	SYNAPTIC VESICLE MEMBRANE PROTEIN VAT-1 HOMOLOG
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IPI	12464394	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00018	EGF receptor signaling pathway	P00565	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05730	Endogenous cannabinoid signaling	P05746	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IC	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00059	p53 pathway	G04694	p110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	RCA	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00050	Plasminogen activating cascade	P01254	pro-MMP-13	BOVIN|Gene=MMP13|UniProtKB=O77656	Collagenase 3	ISS	8207000	PubMed	PTHR10201:SF165	COLLAGENASE 3
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00045	Notch signaling pathway	P01099	Notch	MOUSE|MGI=MGI=99460|UniProtKB=Q61982	Neurogenic locus notch homolog protein 3	IC	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00059	p53 pathway	G04694	p110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01169	Vav	MOUSE|MGI=MGI=98923|UniProtKB=P27870	Proto-oncogene vav	ISS	10661401	PubMed	PTHR22826:SF112	PROTO-ONCOGENE VAV
P00018	EGF receptor signaling pathway	P00551	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00373	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00010	B cell activation	P00400	Btk	BOVIN|Ensembl=ENSBTAG00000019250|UniProtKB=Q3ZC95	Tyrosine-protein kinase	ISS	10521450	PubMed	PTHR24418:SF92	TYROSINE-PROTEIN KINASE BTK
P04393	Ras Pathway	P04558	p38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IDA	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00025	Hedgehog signaling pathway	P00682	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01457	GBeta	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00054	Toll receptor signaling pathway	P01373	CD14	HUMAN|HGNC=1628|UniProtKB=P08571	Monocyte differentiation antigen CD14	ISS			PTHR10630:SF3	MONOCYTE DIFFERENTIATION ANTIGEN CD14
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	CAEBR|Gene=CBG02059|UniProtKB=A8WRW6	Protein CBR-UNC-2 (Fragment)	ISS	14624853	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P00046	Oxidative stress response	P01138	MKK4	RAT|RGD=1311192|UniProtKB=A0A0G2K3R1	Protein Map3k4	ISS	9079650	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	ARATH|TAIR=AT5G07880|UniProtKB=Q9SD96	SNAP25 homologous protein SNAP29	IC			PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-030131-9966|UniProtKB=Q6TH03	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	BOVIN|Ensembl=ENSBTAG00000016187|UniProtKB=F1N213	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00025	Hedgehog signaling pathway	P00682	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00936	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	MONDO|Ensembl=ENSMODG00000013540|UniProtKB=F7CLY1	Uncharacterized protein	ISS	2187864	PubMed	PTHR11800:SF2	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3
P02738	De novo purine biosynthesis	P02900	AICAR transformylase	METAC|EnsemblGenome=MA_4012|UniProtKB=Q8TIX7	Phosphoribosylaminoimidazolecarboxamide formyltransferase	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P00021	FGF signaling pathway	P00643	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00034	Integrin signalling pathway	P00931	Integrin beta	MACMU|Ensembl=ENSMMUG00000003289|UniProtKB=F7FG54	Integrin beta	ISS	7949057	gi	PTHR10082:SF25	INTEGRIN BETA-3
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DANRE|ZFIN=ZDB-GENE-030131-55|UniProtKB=Q6XNL8	Actin	IDA	10974003	PubMed	PTHR11937:SF263	ACTIN
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MACMU|Ensembl=ENSMMUG00000010339|UniProtKB=F6R9V5	Uncharacterized protein	ISS	6264430	PubMed	PTHR10218:SF67	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-1
P04393	Ras Pathway	P04558	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	IDA	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00059	p53 pathway	G04700	PAI	BOVIN|Ensembl=ENSBTAG00000014465|UniProtKB=P13909	Plasminogen activator inhibitor 1	ISS	88329072	PubMed	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00052	TGF-beta signaling pathway	P01284	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	DICPU|Gene=DICPUDRAFT_51488|UniProtKB=F1A411	Putative uncharacterized protein rasC	ISS	94119591	PubMed	PTHR24070:SF251	RAS-LIKE PROTEIN RASC
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IGI	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00047	PDGF signaling pathway	P01153	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	RAT|RGD=1588591|UniProtKB=G3V7T4	Protein Mycl	ISS	12356903	PubMed	PTHR11514:SF1	PROTEIN L-MYC-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	IC	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	CANLF|Ensembl=ENSCAFG00000013067|UniProtKB=E2RJA0	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MOUSE|MGI=MGI=95822|UniProtKB=Q01098	Glutamate receptor ionotropic, NMDA 2C	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	RCA	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF31	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00768	Apaf-1	MOUSE|MGI=MGI=1306796|UniProtKB=O88879	Apoptotic protease-activating factor 1	TAS	14526190	PubMed	PTHR22845:SF5	APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
P00019	Endothelin signaling pathway	P00586	Gq	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00010	B cell activation	P00383	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	RAT|RGD=2739|UniProtKB=Q00961	Glutamate receptor ionotropic, NMDA 2C	ISS	11554549	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	PANTR|Ensembl=ENSPTRG00000004233|UniProtKB=H2Q4N9	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00976	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05918	p38 MAPK pathway	P05919	MAPKAP-K3	MOUSE|MGI=MGI=2143163|UniProtKB=Q3UMW7	MAP kinase-activated protein kinase 3	ISS	11335727	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00050	Plasminogen activating cascade	P01252	MMP-1	HUMAN|HGNC=7155|UniProtKB=P03956	Interstitial collagenase	IGI	3009463	PubMed	PTHR10201:SF151	INTERSTITIAL COLLAGENASE
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	MACMU|Ensembl=ENSMMUG00000011231|UniProtKB=F6WXV4	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00025	Hedgehog signaling pathway	P00693	Ubiquitin ligase	DROME|FlyBase=FBgn0002431|UniProtKB=P51592	E3 ubiquitin-protein ligase hyd	IDA	12421709	PubMed	PTHR11254:SF402	E3 UBIQUITIN-PROTEIN LIGASE UBR5
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MOUSE|MGI=MGI=95777|UniProtKB=Q6R0H7	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00011	Blood coagulation	P00437	Kallikrein	HUMAN|HGNC=6371|UniProtKB=P03952	Plasma kallikrein	ISS	4504877	gi	PTHR44459:SF2	PLASMA KALLIKREIN
P00059	p53 pathway	G01579	PTEN	ARATH|TAIR=AT5G39400|UniProtKB=Q9FLZ5	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN1	ISS			PTHR12305:SF80	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND PROTEIN-TYROSINE-PHOSPHATASE PTEN1
P00056	VEGF signaling pathway	P01411	Ras	DANRE|ZFIN=ZDB-GENE-990415-166|UniProtKB=P79737	GTPase NRas	ISS	9116869	PubMed	PTHR24070:SF189	GTPASE NRAS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00010	B cell activation	P00402	Jnk	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00010	B cell activation	P00372	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	4504111	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04397	p53 pathway by glucose deprivation	P04642	Rheb	PANTR|Ensembl=ENSPTRG00000042112|UniProtKB=H2RG75	Uncharacterized protein	ISS	12842888	PubMed	PTHR24070:SF264	GTP-BINDING PROTEIN RHEB
P00036	Interleukin signaling pathway	P00969	Signaling subunit	MOUSE|MGI=MGI=96560|UniProtKB=Q00560	Interleukin-6 receptor subunit beta	TAS	10210178	PubMed	PTHR23036:SF83	INTERLEUKIN-6 RECEPTOR SUBUNIT BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CHICK|Gene=ACTA2|UniProtKB=P08023	Actin, aortic smooth muscle	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01095	beta	ANOGA|EnsemblGenome=AGAP000966|UniProtKB=Q7QI10	AGAP000966-PA	ISS	22213672	PubMed	PTHR18945:SF771	ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 1
P00005	Angiogenesis	P00238	Ras	MONDO|Ensembl=ENSMODG00000025248|UniProtKB=F7F5X1	Uncharacterized protein	ISS	99084794	PubMed	PTHR24070:SF186	GTPASE KRAS
P00005	Angiogenesis	P00246	Ang-2	CANLF|Ensembl=ENSCAFG00000008597|UniProtKB=A0A8J8	Angiopoietin-2	ISS	9204896	PubMed	PTHR19143:SF199	ANGIOPOIETIN-2
P00006	Apoptosis signaling pathway	P00269	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	20331588	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00048	PI3 kinase pathway	P01199	Galpha	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS			PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00049	Parkinson disease	P01208	Hsp70	PHYPA|Gene=PHYPADRAFT_228249|UniProtKB=A9U4N3	Predicted protein	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P02771	Pyrimidine Metabolism	P03127	Beta-Ureidopropionase	CAEEL|WormBase=WBGene00017440|UniProtKB=Q19437	UreidoPropionase Beta	IEA	17533173	gi	PTHR43674:SF2	BETA-UREIDOPROPIONASE
P00021	FGF signaling pathway	P00642	MEK1-2	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	CANLF|Ensembl=ENSCAFG00000010871|UniProtKB=F1PXA0	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00628	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00739	AGS3	CANLF|Ensembl=ENSCAFG00000019694|UniProtKB=E2R0Q9	Uncharacterized protein	ISS	11121039	PubMed	PTHR10098:SF36	G-PROTEIN-SIGNALING MODULATOR 1
P00048	PI3 kinase pathway	P01206	14-3-3	MOUSE|MGI=MGI=109484|UniProtKB=P63101	14-3-3 protein zeta/delta	ISS	1499718	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00018	EGF receptor signaling pathway	P00560	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04556	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	IDA	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00547	PP2A	ARATH|TAIR=AT3G54930|UniProtKB=Q9SV41	Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' epsilon isoform	ISS			PTHR10257:SF3	PP2A-B', ISOFORM B
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01381	Ubc13	RAT|RGD=621096|UniProtKB=Q9EQX9	Ubiquitin-conjugating enzyme E2 N	ISS			PTHR43902:SF2	UBIQUITIN-CONJUGATING ENZYME E2 N
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CAEEL|WormBase=WBGene00006774|UniProtKB=Q23022	Acetylcholine receptor subunit alpha-type unc-38	IC	85270494	PubMed	PTHR18945:SF769	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-TYPE UNC-38
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IDA	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02918	dUTP pyrophosphatase	CANAL|CGD=CAL0000195525|UniProtKB=P0CY19	Deoxyuridine 5'-triphosphate nucleotidohydrolase	ISS			PTHR11241:SF0	BCDNA.LD08534
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	BOVIN|Ensembl=ENSBTAG00000003075|UniProtKB=E1BK34	Uncharacterized protein	ISS	10409711	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	HUMAN|HGNC=10619|UniProtKB=P78556	C-C motif chemokine 20	IDA	12067311	PubMed	PTHR12015:SF108	C-C MOTIF CHEMOKINE 20
P04372	5-Hydroxytryptamine degredation	P04401	Monoamine Oxidase	RAT|RGD=61898|UniProtKB=P21396	Amine oxidase [flavin-containing] A	ISS	90344230	PubMed	PTHR43563:SF3	AMINE OXIDASE  FLAVIN-CONTAINING  A
P04393	Ras Pathway	P04563	Ets	MOUSE|MGI=MGI=95455|UniProtKB=P27577	Protein C-ets-1	ISS	15699632	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	94280860	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	BRAFL|Gene=BRAFLDRAFT_128184|UniProtKB=C4A0B6	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00010	B cell activation	P00379	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IPI	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00059	p53 pathway	P04633	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01189	PTEN	TAKRU|Ensembl=ENSTRUG00000009851|UniProtKB=H2TJ90	Uncharacterized protein	ISS	21455682	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00010	B cell activation	P00384	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	IDA	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00023	General transcription regulation	P00662	TFIIA complex	ARATH|TAIR=AT1G07480|UniProtKB=O49349	AT1G07480 protein	ISS	600519	OMIM	PTHR12694:SF13	TFIIA-L3
P02723	Adenine and hypoxanthine salvage pathway	P02804	Hypoxanthine phosphoribosyl transferase	PSEAE|EnsemblGenome=PA4645|UniProtKB=Q9HVE7	Probable purine/pyrimidine phosphoribosyl transferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=69430|UniProtKB=P32851	Syntaxin-1A	IC	1321498	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00046	Oxidative stress response	P01134	cPLA2	DANRE|ZFIN=ZDB-GENE-990415-45|UniProtKB=P50392	Cytosolic phospholipase A2	TAS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00015	Circadian clock system	G01497	cry	RAT|RGD=735083|UniProtKB=Q32Q86	Cryptochrome-1	IDA	10217146	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00046	Oxidative stress response	P01132	c-jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04393	Ras Pathway	P04557	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-486685|UniProtKB=F6VT32	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02727	Androgen/estrogene/progesterone biosynthesis	P02826	Estradiol 17beta-dehydrogenase	HUMAN|HGNC=5212|UniProtKB=P37058	Testosterone 17-beta-dehydrogenase 3	ISS			PTHR43899:SF7	TESTOSTERONE 17-BETA-DEHYDROGENASE 3
P00005	Angiogenesis	P00213	FGF	CHICK|Ensembl=ENSGALG00000011835|UniProtKB=P48800	Fibroblast growth factor 2	ISS			PTHR11486:SF83	FIBROBLAST GROWTH FACTOR 2
P00037	Ionotropic glutamate receptor pathway	P01001	KA4	MACMU|Ensembl=ENSMMUG00000022347|UniProtKB=F6ZCH5	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00056	VEGF signaling pathway	P01412	HSP27	MOUSE|MGI=MGI=88515|UniProtKB=P24622	Alpha-crystallin A chain	ISS			PTHR11527:SF36	ALPHA-CRYSTALLIN A CHAIN
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00005	Angiogenesis	P00243	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02748	Isoleucine biosynthesis	P02994	Branched chain amino acid aminotransferase	PANTR|Ensembl=ENSPTRG00000004772|UniProtKB=H2Q5L8	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF51	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, CYTOSOLIC
P02723	Adenine and hypoxanthine salvage pathway	P02805	Adenine phosphorylase	MACMU|Ensembl=ENSMMUG00000019126|UniProtKB=F6T0Z6	Purine nucleoside phosphorylase	ISS			PTHR11904:SF12	PURINE NUCLEOSIDE PHOSPHORYLASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00029	Huntington disease	P00774	Dynein complex	MACMU|Ensembl=ENSMMUG00000007301|UniProtKB=F7F396	Uncharacterized protein	ISS	9454836	PubMed	PTHR12442:SF22	CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN 2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04393	Ras Pathway	P04572	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	HUMAN|HGNC=6695|UniProtKB=O75074	Low-density lipoprotein receptor-related protein 3	IDA	11907044	PubMed	PTHR44062:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	MACMU|Ensembl=ENSMMUG00000003145|UniProtKB=F7EPF6	Uncharacterized protein	ISS	12374786	PubMed	PTHR11767:SF52	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 4
P00021	FGF signaling pathway	P00642	MEK1-2	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IGI	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P02767	Phenylpropionate degradation	P03106	4-Hydroxy-2-ketovalerate aldolase	MYCTU|EnsemblGenome=Rv3534c|UniProtKB=P9WMK5	4-hydroxy-2-oxovalerate aldolase	ISS			PTHR10277:SF3	4-HYDROXY-2-OXOVALERATE ALDOLASE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	9094314	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	HUMAN|HGNC=7881|UniProtKB=P46531	Neurogenic locus notch homolog protein 1	IDA	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00053	T cell activation	P01303	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8617307	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00005	Angiogenesis	P00227	PLA2	RAT|RGD=67366|UniProtKB=P50393	Cytosolic phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	MACMU|Ensembl=ENSMMUG00000013047|UniProtKB=F7H808	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01199	Galpha	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02751	Lysine biosynthesis	P03008	Dihydrodipicolinate synthase	STRCO|EnsemblGenome=CAA20295|UniProtKB=O86841	4-hydroxy-tetrahydrodipicolinate synthase 2	ISS			PTHR12128:SF15	4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00927	Rac	DICPU|Gene=DICPUDRAFT_92985|UniProtKB=F1A084	Putative uncharacterized protein rac1A	ISS	12932731	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00053	T cell activation	P01312	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00021	FGF signaling pathway	P00624	14-3-3	MACMU|Ensembl=ENSMMUG00000006489|UniProtKB=F7EFF6	14-3-3 protein zeta/delta	ISS	12615066	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00005	Angiogenesis	P00223	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	ISS	1504106	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00475	Frizzled	CHICK|Ensembl=ENSGALG00000017242|UniProtKB=Q9IA05	Frizzled-4	IDA	11212302	PubMed	PTHR11309:SF23	FRIZZLED-4
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01230	Src kinase	MONDO|Ensembl=ENSMODG00000017905|UniProtKB=F7FG65	Tyrosine-protein kinase	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	MOUSE|MGI=MGI=1930705|UniProtKB=P61264	Syntaxin-1B	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00034	Integrin signalling pathway	P00916	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IC	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MONDO|Ensembl=ENSMODG00000023805|UniProtKB=F7F082	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P04393	Ras Pathway	P04556	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00054	Toll receptor signaling pathway	P01356	ERK2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02743	Formyltetrahydroformate biosynthesis	P02953	Cobalamin dependent homocysteine transmethylase	MOUSE|MGI=MGI=894292|UniProtKB=A6H5Y3	Methionine synthase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	RAT|RGD=621060|UniProtKB=O88777	Presenilin-2	TAS	9332390	PubMed	PTHR10202:SF13	PRESENILIN-2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00048	PI3 kinase pathway	P01188	Gbetagamma	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00321	HSP70	MOUSE|MGI=MGI=96244|UniProtKB=Q61696	Heat shock 70 kDa protein 1A	ISS	12150907	PubMed	PTHR19375:SF223	HEAT SHOCK 70 KDA PROTEIN 1A-RELATED
P00034	Integrin signalling pathway	P00920	SOS	DROME|FlyBase=FBgn0001965|UniProtKB=P26675	Protein son of sevenless	IPI	476780	gi	PTHR23113:SF99	PROTEIN SON OF SEVENLESS
P00053	T cell activation	P01300	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	RAT|RGD=67398|UniProtKB=Q66HB1	Protein Tbp	ISS	600075	OMIM	PTHR10126:SF20	TATA-BOX-BINDING PROTEIN
P00047	PDGF signaling pathway	P01173	STAT	MACMU|Ensembl=ENSMMUG00000010705|UniProtKB=F7G8V4	Signal transducer and activator of transcription	ISS	10835485	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MACMU|Ensembl=ENSMMUG00000010904|UniProtKB=F7GLY5	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	G01575	GADD45	HUMAN|HGNC=4095|UniProtKB=P24522	Growth arrest and DNA damage-inducible protein GADD45 alpha	IGI	10097101	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P00048	PI3 kinase pathway	P01192	p110	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01219	SAPK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	NAS	10207617	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01451	Galpha	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01168	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	TAS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=1858235|UniProtKB=Q9R0M0	Cadherin EGF LAG seven-pass G-type receptor 2	IDA	8120095	PubMed	PTHR24026:SF32	CADHERIN EGF LAG SEVEN-PASS G-TYPE RECEPTOR 2
P00019	Endothelin signaling pathway	P00570	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P05918	p38 MAPK pathway	P06037	TAK1	RAT|RGD=1309438|UniProtKB=P0C8E4	Mitogen-activated protein kinase kinase kinase 7	ISS	10683140	PubMed	PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00029	Huntington disease	P00797	p53	CANLF|Gene=TP53|UniProtKB=Q29537	Cellular tumor antigen p53	TAS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P06664	Gonadotropin-releasing hormone receptor pathway	P06836	PG Rcs	MOUSE|MGI=MGI=97796|UniProtKB=P43117	Prostaglandin F2-alpha receptor	RCA			PTHR11866:SF4	PROSTAGLANDIN F2-ALPHA RECEPTOR
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00036	Interleukin signaling pathway	P00985	PDK1/2	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	ISS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00021	FGF signaling pathway	P00623	FGF	MONDO|Ensembl=ENSMODG00000003900|UniProtKB=F7D846	Fibroblast growth factor (Fragment)	ISS			PTHR11486:SF27	FIBROBLAST GROWTH FACTOR 16
P00029	Huntington disease	P00807	Actin	RAT|RGD=2026|UniProtKB=P68035	Actin, alpha cardiac muscle 1	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00018	EGF receptor signaling pathway	P00555	MKK4,7	MOUSE|MGI=MGI=1346869|UniProtKB=P47809	Dual specificity mitogen-activated protein kinase kinase 4	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IC	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00010	B cell activation	P00391	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00313	IKK	PANTR|Ensembl=ENSPTRG00000033948|UniProtKB=H2RBD4	Conserved helix-loop-helix ubiquitous kinase	ISS	9346484	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00030	Hypoxia response via HIF activation	P00819	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	TAS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	RAT|RGD=71038|UniProtKB=Q9QYW4	Growth differentiation factor 9	TAS	9759503	PubMed	PTHR11848:SF19	GROWTH/DIFFERENTIATION FACTOR 9
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	BOVIN|Ensembl=ENSBTAG00000008837|UniProtKB=P67868	Casein kinase II subunit beta	IDA	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00010	B cell activation	P00398	IP3R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	PANTR|Ensembl=ENSPTRG00000020099|UniProtKB=H2QVX6	Uncharacterized protein	ISS	7637782	PubMed	PTHR11647:SF56	DIHYDROPYRIMIDINASE-RELATED PROTEIN 2
P00057	Wnt signaling pathway	P01472	Histone deacetylase	CHICK|Gene=HDAC3|UniProtKB=P56520	Histone deacetylase 3	IDA	10485845	PubMed	PTHR10625:SF132	HISTONE DEACETYLASE 3
P00034	Integrin signalling pathway	P00906	Rap1	CANLF|Ensembl=ENSCAFG00000004098|UniProtKB=E2QTM5	Uncharacterized protein	ISS			PTHR24073:SF269	DNAJ HOMOLOG SUBFAMILY C MEMBER 27
P06664	Gonadotropin-releasing hormone receptor pathway	P06811	SRF	MOUSE|MGI=MGI=106658|UniProtKB=Q9JM73	Serum response factor	RCA	15170389	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00010	B cell activation	P00384	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	ISS	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00005	Angiogenesis	P00206	Wnt	BOVIN|Ensembl=ENSBTAG00000014291|UniProtKB=A6H6X8	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00049	Parkinson disease	P01230	Src kinase	MONDO|Ensembl=ENSMODG00000009310|UniProtKB=F7GJZ7	Tyrosine-protein kinase	ISS	12665526	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00047	PDGF signaling pathway	P01171	PLCgamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00004	Alzheimer disease-presenilin pathway	P00125	Ire-1 C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000016799|UniProtKB=F1MM00	Uncharacterized protein	ISS	10619423	PubMed	PTHR13954:SF17	SERINE/THREONINE-PROTEIN KINASE/ENDORIBONUCLEASE IRE1
P00029	Huntington disease	P00799	JNK-2	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00035	Interferon-gamma signaling pathway	P00952	Jak2	DANRE|ZFIN=ZDB-GENE-980526-481|UniProtKB=F1QWX8	Tyrosine-protein kinase	TAS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00543	ERK1-2	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00583	cPLA2	CANLF|Ensembl=ENSCAFG00000013778|UniProtKB=F6UQ33	Phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05734	Synaptic vesicle trafficking	P05774	NSF	YEAST|SGD=S000000284|UniProtKB=P18759	Vesicular-fusion protein SEC18	TAS	2657434	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00048	PI3 kinase pathway	P01202	p85	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	G04714	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00010	B cell activation	P00402	Jnk	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00049	Parkinson disease	P01238	14-3-3	RAT|RGD=3979|UniProtKB=P68255	14-3-3 protein theta	ISS	9211421	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P05734	Synaptic vesicle trafficking	P05775	Synapsin	MACMU|Ensembl=ENSMMUG00000001120|UniProtKB=F6TA37	Synapsin-2 isoform IIa	ISS	600755	OMIM	PTHR10841:SF20	SYNAPSIN-2
P00055	Transcription regulation by bZIP transcription factor	P01398	TFIIEalpha	DROME|FlyBase=FBgn0015828|UniProtKB=O96880	GH11150p	ISS			PTHR13097:SF7	NOVEL PROTEIN SIMILAR TO VERTEBRATE GENERAL TRANSCRIPTION FACTOR IIE POLYPEPTIDE 1 ALPHA 56KDA  GTF2E1
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	BOVIN|Gene=DHFR|UniProtKB=P00376	Dihydrofolate reductase	ISS			PTHR22778:SF16	DIHYDROFOLATE REDUCTASE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MOUSE|MGI=MGI=1915472|UniProtKB=P68372	Tubulin beta-4B chain	ISS	9454836	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IC	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00748	Gbeta5L	XENTR|Xenbase=XB-GENE-977853|UniProtKB=F7EBE7	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00036	Interleukin signaling pathway	P00996	STAT	HUMAN|HGNC=11367|UniProtKB=P51692	Signal transducer and activator of transcription 5B	IC	95236292	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00006	Apoptosis signaling pathway	P00317	Fos	RAT|RGD=2626|UniProtKB=P12841	Proto-oncogene c-Fos	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00021	FGF signaling pathway	P00638	PLCgamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00049	Parkinson disease	P01227	20S proteasome	CAEEL|WormBase=WBGene00003926|UniProtKB=Q95008	Proteasome subunit alpha type-5	TAS	12859888	PubMed	PTHR11599:SF14	PROTEASOME SUBUNIT ALPHA TYPE-5
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00057	Wnt signaling pathway	P01437	TCF	PANTR|Ensembl=ENSPTRG00000017236|UniProtKB=H2QRH6	Uncharacterized protein	ISS	9118222	PubMed	PTHR10373:SF33	TRANSCRIPTION FACTOR 7
P00047	PDGF signaling pathway	P01153	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00029	Huntington disease	P00790	beta-Tubulin	PANTR|Ensembl=ENSPTRG00000008496|UniProtKB=H2QBS3	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00036	Interleukin signaling pathway	P00973	PKB	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00007	Axon guidance mediated by semaphorins	P00340	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00057	Wnt signaling pathway	P01435	SWI/SNF	ORNAN|Ensembl=ENSOANG00000013921|UniProtKB=F7DUC5	Uncharacterized protein	ISS	11532957	PubMed	PTHR10799:SF887	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5
P04395	Vasopressin synthesis	P04590	Vasopressin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00021	FGF signaling pathway	P00645	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8704|UniProtKB=Q9Y5G7	Protocadherin gamma-A6	IDA	8120095	PubMed	PTHR24028:SF107	PROTOCADHERIN GAMMA-A6
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MONDO|Ensembl=ENSMODG00000008086|UniProtKB=F6YJ34	Ribosomal protein S6 kinase	ISS	10480933	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00047	PDGF signaling pathway	P01148	Grb2	CAEBR|Gene=CBG16856|UniProtKB=A8XPY6	Protein CBR-SEM-5	ISS	4504111	gi	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00005	Angiogenesis	P00224	PDGF	HUMAN|HGNC=8799|UniProtKB=P04085	Platelet-derived growth factor subunit A	IEP	14504135	PubMed	PTHR11633:SF3	PLATELET-DERIVED GROWTH FACTOR SUBUNIT A
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P02759	Pyridoxal-5-phosphate biosynthesis	P03061	Pyridoxine-5-phosphate oxidase	SCHPO|PomBase=SPAC1093.02|UniProtKB=Q9UTQ1	Probable pyridoxamine 5'-phosphate oxidase	ISS	11859360	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IDA	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00029	Huntington disease	P00797	p53	DANRE|ZFIN=ZDB-GENE-990415-270|UniProtKB=P79734	Cellular tumor antigen p53	ISS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12960248	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00021	FGF signaling pathway	P00629	PP2A	MACMU|Ensembl=ENSMMUG00000008205|UniProtKB=F7GWP9	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	ISS	10092233	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	IDA	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	STRPU|Gene=CYIIIA|UniProtKB=P53474	Actin, cytoskeletal 3A	IDA	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	SCHPO|PomBase=SPAC637.10c|UniProtKB=O94444	26S proteasome regulatory subunit rpn10	ISS	21848401	PubMed	PTHR10223:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	PANTR|Ensembl=ENSPTRG00000016548|UniProtKB=H2QQC5	Uncharacterized protein	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00011	Blood coagulation	P00417	TFPI	HUMAN|HGNC=11760|UniProtKB=P10646	Tissue factor pathway inhibitor	ISS	6094466	gi	PTHR10083:SF311	TISSUE FACTOR PATHWAY INHIBITOR
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	BOVIN|Gene=SLC1A1|UniProtKB=Q95135	Excitatory amino acid transporter 3	ISS	94365697	PubMed	PTHR11958:SF69	EXCITATORY AMINO ACID TRANSPORTER 3
P00029	Huntington disease	G01532	PolyQ HTT	RAT|RGD=68337|UniProtKB=P51111	Huntingtin	TAS	7620118	PubMed	PTHR10170:SF10	HUNTINGTIN
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00030	Hypoxia response via HIF activation	P00819	AKT	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	12655147	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00047	PDGF signaling pathway	P01159	SOS	DICDI|dictyBase=DDB_G0276019|UniProtKB=Q552M5	Ras guanine nucleotide exchange factor Y	ISS			PTHR23113:SF99	PROTEIN SON OF SEVENLESS
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	CHICK|Ensembl=ENSGALG00000006576|UniProtKB=E1BUE5	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00056	VEGF signaling pathway	P01425	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00144	Ire-1	ORYSJ|EnsemblGenome=OS07G0471000|UniProtKB=Q7XIT1	Os07g0471000 protein	IDA	10619423	PubMed	PTHR13954:SF6	INOSITOL-REQUIRING ENZYME-1
P02738	De novo purine biosynthesis	P02891	GDP kinase	MACMU|Ensembl=ENSMMUG00000000612|UniProtKB=F7CDE0	Nucleoside diphosphate kinase	ISS			PTHR11349:SF49	NUCLEOSIDE DIPHOSPHATE KINASE, MITOCHONDRIAL
P00054	Toll receptor signaling pathway	G01550	Gene trancription	MOUSE|MGI=MGI=97798|UniProtKB=Q05769	Prostaglandin G/H synthase 2	ISS	12163371	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	IDA	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00054	Toll receptor signaling pathway	P01354	NFkappaB	DROME|FlyBase=FBgn0260632|UniProtKB=P15330	Embryonic polarity protein dorsal	ISS	9510254	PubMed	PTHR24169:SF20	DORSAL-RELATED IMMUNITY FACTOR DIF-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00021	FGF signaling pathway	P00633	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00059	p53 pathway	G04694	p110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	RCA	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	BACSU|EnsemblGenome=BSU25300|UniProtKB=P19079	Cytidine deaminase	ISS			PTHR11644:SF16	SUBFAMILY NOT NAMED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00048	PI3 kinase pathway	P01185	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00748	Gbeta5L	HUMAN|HGNC=4401|UniProtKB=O14775	Guanine nucleotide-binding protein subunit beta-5	IEA	10051575	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	RAT|RGD=1359133|UniProtKB=Q6AY07	Fructose-bisphosphate aldolase	ISS	3391172	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00012	Cadherin signaling pathway	P00475	Frizzled	RAT|RGD=628816|UniProtKB=G3V6L1	Frizzled homolog 6 (Drosophila)	ISS	8717036	PubMed	PTHR11309:SF75	FRIZZLED-6
P00034	Integrin signalling pathway	P00936	PI3K	ARATH|TAIR=AT1G60490|UniProtKB=P42339	Phosphatidylinositol 3-kinase VPS34	IPI	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00047	PDGF signaling pathway	P01143	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00059	p53 pathway	G04694	p110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00780	Microtubule	XENTR|Xenbase=XB-GENE-969447|UniProtKB=Q0IIR4	Tubulin, beta 2C	ISS	12932731	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00014	Cholesterol biosynthesis	P00498	Hydroxymethyl glutaryl CoA synthase	MONDO|Ensembl=ENSMODG00000020279|UniProtKB=F7C0S7	Uncharacterized protein	ISS	600234	OMIM	PTHR43323:SF4	HYDROXYMETHYLGLUTARYL-COA SYNTHASE, CYTOPLASMIC
P06959	CCKR signaling map	P07140	PKCtheta	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	RCA	21810446	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	XENTR|Xenbase=XB-GENE-6053489|UniProtKB=F6S8L5	Tyrosine-protein kinase	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00052	TGF-beta signaling pathway	P01284	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00750	Rhodopsin kinase	MOUSE|MGI=MGI=1345146|UniProtKB=Q9WVL4	Rhodopsin kinase	ISS	8288567	PubMed	PTHR24355:SF11	RHODOPSIN KINASE
P00006	Apoptosis signaling pathway	P00269	MAPK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	11790551	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00047	PDGF signaling pathway	P01154	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P04393	Ras Pathway	P04560	AP1	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00012	Cadherin signaling pathway	P00470	F-actin	DICPU|Gene=DICPUDRAFT_48914|UniProtKB=F0ZK40	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF154	ACTIN-17-RELATED
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00189	Fzd	XENTR|Xenbase=XB-GENE-479707|UniProtKB=F6QAW3	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF126	FRIZZLED-5
P00021	FGF signaling pathway	P00642	MEK1-2	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02769	Purine metabolism	P03118	Guanine Deaminase	MOUSE|MGI=MGI=95678|UniProtKB=Q9R111	Guanine deaminase	ISS	11962625	PubMed	PTHR11271:SF6	GUANINE DEAMINASE
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05734	Synaptic vesicle trafficking	P05779	Synaptobrevin	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IDA	11832947	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MOUSE|MGI=MGI=1202879|UniProtKB=Q924A0	Transcription factor 7-like 2	IEP	11266476	PubMed	PTHR10373:SF32	TRANSCRIPTION FACTOR 7-LIKE 2
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00036	Interleukin signaling pathway	P00981	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	RCA	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00025	Hedgehog signaling pathway	P00691	CBP	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00047	PDGF signaling pathway	P01143	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00922	Collagen	CHICK|Gene=COL9A3|UniProtKB=P32017	Collagen alpha-3(IX) chain	IDA	10778855	PubMed	PTHR44865:SF1	COLLAGEN ALPHA-3 IX  CHAIN
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MOUSE|MGI=MGI=104589|UniProtKB=P63268	Actin, gamma-enteric smooth muscle	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00048	PI3 kinase pathway	P01185	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MACMU|Ensembl=ENSMMUG00000009341|UniProtKB=F6UA54	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00021	FGF signaling pathway	P00624	14-3-3	BOVIN|Ensembl=ENSBTAG00000002108|UniProtKB=Q3SZI4	14-3-3 protein theta	ISS	5803227	gi	PTHR18860:SF3	14-3-3 PROTEIN THETA
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00048	PI3 kinase pathway	P01196	PDK1	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	15210700	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00021	FGF signaling pathway	P00624	14-3-3	MONDO|Ensembl=ENSMODG00000006158|UniProtKB=F7BS95	Uncharacterized protein	ISS	92283271	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IDA	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00005	Angiogenesis	P00182	p38MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	RCA	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00054	Toll receptor signaling pathway	P01346	TLR	CHICK|Gene=TLR2-2|UniProtKB=Q9DGB6	Toll-like receptor 2 type-2	ISS			PTHR24365:SF17	TOLL-LIKE RECEPTOR 2
P00017	DNA replication	P00533	Pol delta	NEUCR|EnsemblGenome=EFNCRG00000003418|UniProtKB=Q1K7B3	DNA polymerase delta subunit 2	NAS	16944625	gi	PTHR10416:SF0	DNA POLYMERASE DELTA SUBUNIT 2
P00034	Integrin signalling pathway	P00944	Actin	HUMAN|HGNC=144|UniProtKB=P63261	Actin, cytoplasmic 2	IPI	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DICDI|dictyBase=DDB_G0283907|UniProtKB=P34099	cAMP-dependent protein kinase catalytic subunit	IC	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00047	PDGF signaling pathway	P01167	Ets	RAT|RGD=1560743|UniProtKB=D3ZWM8	Protein Elf4	ISS	15298723	PubMed	PTHR11849:SF170	ETS-RELATED TRANSCRIPTION FACTOR ELF-4
P02738	De novo purine biosynthesis	P02902	ADP reductase	CAEEL|WormBase=WBGene00004391|UniProtKB=Q03604	Ribonucleoside-diphosphate reductase large subunit	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	DANRE|ZFIN=ZDB-GENE-030131-8013|UniProtKB=F1QBT6	Uncharacterized protein	ISS	12497607	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00037	Ionotropic glutamate receptor pathway	P01005	NR2D	HUMAN|HGNC=4588|UniProtKB=O15399	Glutamate receptor ionotropic, NMDA 2D	ISS	14698601	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	BOVIN|Ensembl=ENSBTAG00000026580|UniProtKB=F1MB93	Uncharacterized protein	ISS	12441358	PubMed	PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	XENTR|Xenbase=XB-GENE-478483|UniProtKB=F6W2E6	Glycoprotein hormones alpha chain	ISS	89325834	PubMed	PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P00029	Huntington disease	P00775	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00012	Cadherin signaling pathway	P00475	Frizzled	PANTR|Ensembl=ENSPTRG00000029908|UniProtKB=H2R050	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF90	FRIZZLED-8
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00006	Apoptosis signaling pathway	P00257	Bcl-xL	DANRE|ZFIN=ZDB-GENE-010730-1|UniProtKB=Q90Z98	Bcl-XL-like protein 1	ISS	11406282	PubMed	PTHR11256:SF12	BCL-2-LIKE PROTEIN 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PANTR|Ensembl=ENSPTRG00000007124|UniProtKB=H2Q9I8	Myosin IE	ISS			PTHR13140:SF341	UNCONVENTIONAL MYOSIN-IE
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P05915	Opioid proenkephalin pathway	P05994	G-protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00022	General transcription by RNA polymerase I	P00657	TBP	DICDI|dictyBase=DDB_G0275617|UniProtKB=P26355	TATA-box-binding protein	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	TAS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00226	Delta/Serrate	RAT|RGD=70953|UniProtKB=O88671	Delta-like protein 3	ISS	12175503	PubMed	PTHR24044:SF308	DELTA-LIKE PROTEIN 3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CAEEL|WormBase=WBGene00001679|UniProtKB=P17343	Guanine nucleotide-binding protein subunit beta-1	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P05915	Opioid proenkephalin pathway	P05991	Enkephalin	HUMAN|HGNC=8831|UniProtKB=P01210	Proenkephalin-A	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00050	Plasminogen activating cascade	P01250	MMP-13	MOUSE|MGI=MGI=1202395|UniProtKB=O70138	Neutrophil collagenase	ISS	12834808	PubMed	PTHR10201:SF137	NEUTROPHIL COLLAGENASE
P04393	Ras Pathway	P04572	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00023	General transcription regulation	P00668	TFIIB	PANTR|Ensembl=ENSPTRG00000000932|UniProtKB=H2PZC5	General transcription factor IIB	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P00021	FGF signaling pathway	P00646	RasGAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	IPI	2842690	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00050	Plasminogen activating cascade	P01254	pro-MMP-13	MOUSE|MGI=MGI=1340026|UniProtKB=P33435	Collagenase 3	ISS	12834808	PubMed	PTHR10201:SF165	COLLAGENASE 3
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	METAC|EnsemblGenome=MA_4102|UniProtKB=Q9HH99	Pyrroline-5-carboxylate reductase	ISS			PTHR11645:SF0	PYRROLINE-5-CARBOXYLATE REDUCTASE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	DROME|FlyBase=FBgn0031461|UniProtKB=Q9VQG9	Dawdle, isoform A	ISS	12537572	PubMed	PTHR11848:SF226	DAWDLE, ISOFORM A
P05913	Enkephalin release	P05972	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00561	STAT	CANLF|Ensembl=ENSCAFG00000015509|UniProtKB=F1PNW8	Signal transducer and activator of transcription	ISS	96102059	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00047	PDGF signaling pathway	P01171	PLCgamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	DANRE|ZFIN=ZDB-GENE-040426-1179|UniProtKB=Q7SY23	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	ISS			PTHR14516:SF3	DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE, MITOCHONDRIAL
P00029	Huntington disease	P00807	Actin	SCHMA|EnsemblGenome=Smp_202970|UniProtKB=G4VLN1	Putative uncharacterized protein Smp_202970	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00047	PDGF signaling pathway	P01148	Grb2	DANRE|ZFIN=ZDB-GENE-040426-1975|UniProtKB=Q6PC73	Growth factor receptor-bound protein 2	ISS	8479536	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01160	IP3 receptor	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	IC	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00057	Wnt signaling pathway	P01465	Ggamma	MOUSE|MGI=MGI=102705|UniProtKB=P63213	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IDA	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00053	T cell activation	P01297	MEKK	MACMU|Ensembl=ENSMMUG00000012387|UniProtKB=F7EB20	Uncharacterized protein	RCA	8940199	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-7595|UniProtKB=Q6PBR4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PHYPA|Gene=PHYPADRAFT_226658|UniProtKB=A9TYG3	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	BOVIN|Ensembl=ENSBTAG00000039151|UniProtKB=F6R5F6	Uncharacterized protein	ISS	12181435	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00034	Integrin signalling pathway	P00948	Rho	MONDO|Ensembl=ENSMODG00000003575|UniProtKB=F6RYV4	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF24	RHO-RELATED GTP-BINDING PROTEIN RHOE
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02751	Lysine biosynthesis	P03009	Aspartokinase	SCHPO|PomBase=SPBC19F5.04|UniProtKB=O60163	Probable aspartokinase	ISS			PTHR21499:SF3	ASPARTOKINASE
P00029	Huntington disease	P00786	ARF	SCLS1|Gene=SS1G_06730|UniProtKB=A7EN31	ADP-ribosylation factor 1	ISS	12932731	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00056	VEGF signaling pathway	P01417	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00010	B cell activation	P00373	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05913	Enkephalin release	P05978	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00006	Apoptosis signaling pathway	P00321	HSP70	CAEEL|WormBase=WBGene00002008|UniProtKB=P20163	Heat shock 70 kDa protein D	ISS	12150907	PubMed	PTHR19375:SF157	HEAT SHOCK 70 KDA PROTEIN D
P00025	Hedgehog signaling pathway	P00682	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00632	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2747|UniProtKB=P35349	Metabotropic glutamate receptor 6	IDA	9407094	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	MOUSE|MGI=MGI=108007|UniProtKB=P48543	G protein-activated inward rectifier potassium channel 3	IDA	2433589	PubMed	PTHR11767:SF17	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 3
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MOUSE|MGI=MGI=108474|UniProtKB=Q61089	Frizzled-6	TAS	11212302	PubMed	PTHR11309:SF75	FRIZZLED-6
P00006	Apoptosis signaling pathway	P00278	Bag	MACMU|Ensembl=ENSMMUG00000020148|UniProtKB=F7H9T2	Uncharacterized protein	ISS	7834747	PubMed	PTHR12329:SF16	BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	MACMU|Ensembl=ENSMMUG00000009928|UniProtKB=F6Y5E5	Uncharacterized protein	ISS	12374786	PubMed	PTHR11767:SF17	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 3
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00021	FGF signaling pathway	P00636	FGFR1-4	HUMAN|HGNC=3691|UniProtKB=P22455	Fibroblast growth factor receptor 4	IGI	11549253	PubMed	PTHR24416:SF343	FIBROBLAST GROWTH FACTOR RECEPTOR 4
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00047	PDGF signaling pathway	P01161	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00022	General transcription by RNA polymerase I	P00654	TTF-I	PANTR|Ensembl=ENSPTRG00000021496|UniProtKB=H2QY30	Uncharacterized protein	ISS	95320168	PubMed	PTHR10641:SF939	TRANSCRIPTION TERMINATION FACTOR 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05730	Endogenous cannabinoid signaling	P05751	Galpha	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04393	Ras Pathway	P04558	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00047	PDGF signaling pathway	P01164	PDK1/2	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	ISS	12855688	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ORYSJ|Gene=Os01g0665200|UniProtKB=Q5SN53	Mitogen-activated protein kinase 8	IDA			PTHR24055:SF219	SUBFAMILY NOT NAMED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	PANTR|Ensembl=ENSPTRG00000001056|UniProtKB=H2PZL0	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P05734	Synaptic vesicle trafficking	P05770	Munc18	CANLF|Ensembl=ENSCAFG00000020125|UniProtKB=F1P7D2	Uncharacterized protein	ISS	8108429	PubMed	PTHR11679:SF35	SYNTAXIN-BINDING PROTEIN 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02728	Arginine biosynthesis	P02841	argininosuccinate lyase	DROME|FlyBase=FBgn0032076|UniProtKB=Q9VLG9	CG9510, isoform B	ISS			PTHR43814:SF1	ARGININOSUCCINATE LYASE
P00030	Hypoxia response via HIF activation	P00819	AKT	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	IC	14526383	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00056	VEGF signaling pathway	P01409	cPLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P06209	ALP23B signaling pathway	P06220	BABO	DROME|FlyBase=FBgn0011300|UniProtKB=A1Z7L8	Receptor protein serine/threonine kinase	IEA	http://www.reactome.org/	Website	PTHR23255:SF71	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	IC	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00021	FGF signaling pathway	P00645	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	20264070	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	RAT|RGD=2869|UniProtKB=P24062	Insulin-like growth factor 1 receptor	ISS	11182407	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00013	Cell cycle	P00484	Cyclin D	STRPU|EnsemblGenome=SPU_007013|UniProtKB=Q964G0	Cyclin D	IEP	12356903	PubMed	PTHR10177:SF246	CYCLIN D, ISOFORM D
P00052	TGF-beta signaling pathway	P01286	TGFbeta	DANRE|ZFIN=ZDB-GENE-980528-2059|UniProtKB=F1QAD6	Uncharacterized protein	TAS	9759503	PubMed	PTHR11848:SF165	BONE MORPHOGENETIC PROTEIN 4
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00010	B cell activation	P00398	IP3R	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	IGI	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P06664	Gonadotropin-releasing hormone receptor pathway	P06773	gnai/o	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00048	PI3 kinase pathway	P01202	p85	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	IC	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	MONDO|Ensembl=ENSMODG00000012050|UniProtKB=F7ALE8	Uncharacterized protein	ISS	1904011	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00049	Parkinson disease	P01219	SAPK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	15528206	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	12657601	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	HUMAN|HGNC=4045|UniProtKB=O75084	Frizzled-7	TAS	8717036	PubMed	PTHR11309:SF31	FRIZZLED-7
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	IDA	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00925	MEK	BOVIN|Ensembl=ENSBTAG00000010576|UniProtKB=A4IFH7	MAP2K3 protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00052	TGF-beta signaling pathway	P01288	FKBP12	ASHGO|EnsemblGenome=AGOS_AFR064C|UniProtKB=Q754K8	FK506-binding protein 1	ISS			PTHR10516:SF341	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00048	PI3 kinase pathway	P01199	Galpha	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	IC	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02721	ATP synthesis	P02791	F1 alpha	MONDO|Ensembl=ENSMODG00000003241|UniProtKB=F6THT5	ATP synthase subunit alpha	ISS	11479684	PubMed	PTHR43089:SF5	ATP SYNTHASE SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P06664	Gonadotropin-releasing hormone receptor pathway	P06705	PLCbeta	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	RCA	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00010	B cell activation	P00379	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IGI	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00045	Notch signaling pathway	G01541	E(spl)-C genes	XENTR|Xenbase=XB-GENE-487995|UniProtKB=Q5PPM5	Transcription factor HES-1	ISS	14973298	PubMed	PTHR10985:SF19	TRANSCRIPTION FACTOR HES-1
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	RAT|RGD=3803|UniProtKB=P21707	Synaptotagmin-1	IDA	11438518	PubMed	PTHR10024:SF239	SYNAPTOTAGMIN-1
P06959	CCKR signaling map	P07142	YES1	HUMAN|HGNC=12841|UniProtKB=P07947	Tyrosine-protein kinase Yes	RCA	22617836	PubMed	PTHR24418:SF90	TYROSINE-PROTEIN KINASE YES
P00012	Cadherin signaling pathway	P00463	betacatenin	HUMAN|HGNC=2514|UniProtKB=P35222	Catenin beta-1	IDA	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00010	B cell activation	P00367	NFAT	RAT|RGD=1310749|UniProtKB=D3Z9H7	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	ISS	12787506	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00054	Toll receptor signaling pathway	P01368	MKK2	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MACMU|Ensembl=ENSMMUG00000011910|UniProtKB=F7HMW7	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF157	GROWTH/DIFFERENTIATION FACTOR 2
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05918	p38 MAPK pathway	P06021	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00011	Blood coagulation	P00411	PAI-1	HUMAN|HGNC=8583|UniProtKB=P05121	Plasminogen activator inhibitor 1	ISS	189578	gi	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	ARATH|TAIR=AT5G20490|UniProtKB=F4K5J1	Myosin-17	IC			PTHR13140:SF510	MYOSIN-17-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05730	Endogenous cannabinoid signaling	P05751	Galpha	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00030	Hypoxia response via HIF activation	P00821	Prolyl Hydroxylase	MONDO|Ensembl=ENSMODG00000017625|UniProtKB=F6ZT25	Uncharacterized protein	ISS	12912907	PubMed	PTHR12907:SF5	EGL NINE HOMOLOG 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	BOVIN|Gene=RGS2|UniProtKB=Q0P5H5	Regulator of G-protein signaling 2	ISS	8756726	PubMed	PTHR10845:SF43	REGULATOR OF G-PROTEIN SIGNALING 2
P00021	FGF signaling pathway	P00643	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00384	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IDA	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00057	Wnt signaling pathway	P01458	Protein Kinase C	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	IDA	10395542	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	BOVIN|Ensembl=ENSBTAG00000020887|UniProtKB=F1MP22	Uncharacterized protein	ISS	11976940	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00018	EGF receptor signaling pathway	P00557	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00008	Axon guidance mediated by Slit/Robo	P00348	Robo	CHICK|Ensembl=ENSGALG00000015511|UniProtKB=F1NR30	Uncharacterized protein	ISS			PTHR44096:SF1	ROUNDABOUT HOMOLOG 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00005	Angiogenesis	P00217	STAT3	TAKRU|Ensembl=ENSTRUG00000015348|UniProtKB=H2UQK9	Signal transducer and activator of transcription	ISS	11879641	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00036	Interleukin signaling pathway	P00996	STAT	MOUSE|MGI=MGI=103034|UniProtKB=P52633	Signal transducer and transcription activator 6	IC	12039028	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00056	VEGF signaling pathway	P01417	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	MONDO|Ensembl=ENSMODG00000020977|UniProtKB=F6S5B1	Uncharacterized protein (Fragment)	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00018	EGF receptor signaling pathway	P00551	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IGI	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000006307|UniProtKB=H2SSM1	Uncharacterized protein	IC			PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01438	PP2A	XENTR|Xenbase=XB-GENE-957526|UniProtKB=K9J7P6	Uncharacterized protein	ISS	8703017	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	TAS	129387	gi	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P05918	p38 MAPK pathway	P06020	p38delta	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00046	Oxidative stress response	P01129	JNK1/2	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00019	Endothelin signaling pathway	P00590	IP3 R	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	IGI	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00021	FGF signaling pathway	P00630	RKIP	MACMU|Ensembl=ENSMMUG00000005098|UniProtKB=F5CI18	Phosphatidylethanolamine-binding protein	ISS	8037677	PubMed	PTHR11362:SF28	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	ISS			PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00019	Endothelin signaling pathway	P00566	ERK	ARATH|TAIR=AT3G59790|UniProtKB=Q9M1Z5	Mitogen-activated protein kinase 10	ISS			PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	HUMAN|HGNC=239|UniProtKB=P40145	Adenylate cyclase type 8	IDA	2491850	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00034	Integrin signalling pathway	P00928	alpha actinin	MOUSE|MGI=MGI=109192|UniProtKB=Q9JI91	Alpha-actinin-2	IPI	2116421	PubMed	PTHR43947:SF4	ALPHA-ACTININ-2
P00020	FAS signaling pathway	P00617	FasL	PANTR|Ensembl=ENSPTRG00000001690|UniProtKB=H2Q0M2	Uncharacterized protein	ISS	7528780	PubMed	PTHR11471:SF33	TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 6
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01407	Erk	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	1482697	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04398	p53 pathway feedback loops 2	P04665	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P01483	Mdm2	BOVIN|Ensembl=ENSBTAG00000010422|UniProtKB=F1MYE6	Uncharacterized protein	ISS	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00034	Integrin signalling pathway	P00922	Collagen	HUMAN|HGNC=2191|UniProtKB=Q05707	Collagen alpha-1(XIV) chain	IDA	10778855	PubMed	PTHR44557:SF1	COLLAGEN ALPHA-1 XIV  CHAIN
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DROME|FlyBase=FBgn0267849|UniProtKB=Q7K0X9	LD23667p	IC	14570579	PubMed	PTHR19957:SF209	LD23667P
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	IDA	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01207	PLD2	PANTR|Ensembl=ENSPTRG00000008610|UniProtKB=H2QBY9	Uncharacterized protein	ISS	9538008	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	RCA	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	DANRE|ZFIN=ZDB-GENE-020125-4|UniProtKB=F1QKT1	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00048	PI3 kinase pathway	P01199	Galpha	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00627	ERK1-2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00015	Circadian clock system	G01500	bmal1	BOVIN|Ensembl=ENSBTAG00000013029|UniProtKB=E1BLF5	Uncharacterized protein	ISS	11163178	PubMed	PTHR23042:SF52	ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 1
P00005	Angiogenesis	P00215	Nck	XENTR|Xenbase=XB-GENE-6085807|UniProtKB=Q66IL5	Nck1 protein	ISS	51702266	gi	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P00054	Toll receptor signaling pathway	P01375	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04398	p53 pathway feedback loops 2	G04714	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00013	Cell cycle	P00481	APC	CHICK|Ensembl=ENSGALG00000028643|UniProtKB=Q5ZL04	Anaphase-promoting complex subunit 10	ISS	14732115	gi	PTHR12936:SF0	ANAPHASE-PROMOTING COMPLEX SUBUNIT 10
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04398	p53 pathway feedback loops 2	P04661	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	129387	gi	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_94959|UniProtKB=C3XYC4	Putative uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00038	JAK/STAT signaling pathway	P01027	STAT	MONDO|Ensembl=ENSMODG00000014816|UniProtKB=F7CHH2	Signal transducer and activator of transcription	ISS	95236292	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P04398	p53 pathway feedback loops 2	P04661	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	TAS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	BOVIN|Ensembl=ENSBTAG00000005410|UniProtKB=O46470	Regulator of G-protein signaling 7	IDA	8756726	PubMed	PTHR10845:SF26	REGULATOR OF G-PROTEIN SIGNALING 7
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00624	14-3-3	PANTR|Ensembl=ENSPTRG00000011641|UniProtKB=H2QHF1	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	ISS	5803227	gi	PTHR18860:SF3	14-3-3 PROTEIN THETA
P00048	PI3 kinase pathway	P01182	Ras	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	ISS	12104050	PubMed	PTHR24070:SF189	GTPASE NRAS
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	NEUCR|EnsemblGenome=EFNCRG00000001308|UniProtKB=Q7SDM3	Myosin-1	IC	22028976	PubMed	PTHR13140:SF663	HEAVY CHAIN, UNCONVENTIONAL MYOSIN
P05915	Opioid proenkephalin pathway	P05995	proenkephalin	BOVIN|Ensembl=ENSBTAG00000004924|UniProtKB=P01211	Proenkephalin-A	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	IC	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01451	Galpha	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	IDA	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	20216076	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00029	Huntington disease	P00810	GAPDH	ARATH|TAIR=AT1G79530|UniProtKB=Q9SAJ6	Glyceraldehyde-3-phosphate dehydrogenase GAPCP1, chloroplastic	IPI			PTHR10836:SF52	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED
P00045	Notch signaling pathway	P01119	NIct	RAT|RGD=3187|UniProtKB=Q07008	Neurogenic locus notch homolog protein 1	IEP	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02922	Orotate phosphoribosyltransferase	PSEAE|EnsemblGenome=PA5331|UniProtKB=P50587	Orotate phosphoribosyltransferase	ISS			PTHR19278:SF36	OROTATE PHOSPHORIBOSYLTRANSFERASE
P00001	Adrenaline and noradrenaline biosynthesis	P00070	VAT2	MOUSE|MGI=MGI=106677|UniProtKB=Q8BRU6	Synaptic vesicular amine transporter	IC	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	DROME|FlyBase=FBgn0000036|UniProtKB=P09478	Acetylcholine receptor subunit alpha-like 1	IC	85270494	PubMed	PTHR18945:SF592	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-LIKE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	HUMAN|HGNC=1954|UniProtKB=P08912	Muscarinic acetylcholine receptor M5	IDA	10069496	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04570	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	IDA	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02781	Threonine biosynthesis	P03192	Aspartate semialdehyde dehydrogenase	ORYSJ|EnsemblGenome=OS01G0926800|UniProtKB=Q8S1X5	Os01g0926800 protein	ISS			PTHR10174:SF158	SUBFAMILY NOT NAMED
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01440	Cadherin	ORNAN|Ensembl=ENSOANG00000002504|UniProtKB=F6VET9	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF290	CADHERIN-10
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00053	T cell activation	P01316	MHC-antigen	MACMU|Ensembl=ENSMMUG00000005534|UniProtKB=F7GF67	Uncharacterized protein	ISS	73139	PubMed	PTHR19944:SF50	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DM ALPHA CHAIN
P05913	Enkephalin release	P05977	G-Protein (s)	MOUSE|MGI=MGI=95774|UniProtKB=Q8CGK7	Guanine nucleotide-binding protein G(olf) subunit alpha	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00010	B cell activation	P00398	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IGI	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00562	p38	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00021	FGF signaling pathway	P00644	p38	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00017	DNA replication	P00531	Pol alpha	MOUSE|MGI=MGI=99660|UniProtKB=P33609	DNA polymerase alpha catalytic subunit	ISS	7654366	PubMed	PTHR10322:SF21	DNA POLYMERASE ALPHA CATALYTIC SUBUNIT
P04376	5HT4 type receptor mediated signaling pathway	P04426	K+ channel	HUMAN|HGNC=6278|UniProtKB=O14649	Potassium channel subfamily K member 3	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00912	Arp2/3	BOVIN|Ensembl=ENSBTAG00000005345|UniProtKB=Q3T035	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00030	Hypoxia response via HIF activation	P00819	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MONDO|Ensembl=ENSMODG00000007084|UniProtKB=F6UEK4	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF26	REGULATOR OF G-PROTEIN SIGNALING 7
P00019	Endothelin signaling pathway	P00566	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ORNAN|Ensembl=ENSOANG00000000460|UniProtKB=F7F4W9	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00047	PDGF signaling pathway	P01159	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	9199552	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	BOVIN|Ensembl=ENSBTAG00000000219|UniProtKB=F1MCL3	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CANLF|Ensembl=ENSCAFG00000015680|UniProtKB=F1P8I8	Uncharacterized protein	ISS			PTHR13140:SF313	UNCONVENTIONAL MYOSIN-VC
P00052	TGF-beta signaling pathway	P01286	TGFbeta	PANTR|Ensembl=ENSPTRG00000011697|UniProtKB=H2QHH9	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF160	GROWTH/DIFFERENTIATION FACTOR 7
P00006	Apoptosis signaling pathway	P00318	PKCs	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	TAKRU|Ensembl=ENSTRUG00000015959|UniProtKB=H2UV27	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05915	Opioid proenkephalin pathway	P05990	K+ channel	HUMAN|HGNC=6278|UniProtKB=O14649	Potassium channel subfamily K member 3	ISS	15282272	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00021	FGF signaling pathway	P00648	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01303	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00018	EGF receptor signaling pathway	P00564	Rac	ORYSJ|Gene=Os01g0229400|UniProtKB=Q9SSX0	Rac-like GTP-binding protein 1	IGI	10485927	PubMed	PTHR24072:SF154	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04396	Vitamin D metabolism and pathway	P04603	1alpha-Hydroxylase	HUMAN|HGNC=33480|UniProtKB=Q4G0S4	Cytochrome P450 27C1	IDA	11013342	PubMed	PTHR24291:SF9	CYTOCHROME P450 27C1
P00025	Hedgehog signaling pathway	P00691	CBP	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00865	Shc	BOVIN|Ensembl=ENSBTAG00000019838|UniProtKB=Q0IIE2	SHC-transforming protein 1	ISS	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00047	PDGF signaling pathway	P01149	MNK1/2	MOUSE|MGI=MGI=894316|UniProtKB=O08605	MAP kinase-interacting serine/threonine-protein kinase 1	ISS	9155017	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	IDA	10553940	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	RCA	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	TAS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00029	Huntington disease	P00778	NMDA receptor	ANOGA|EnsemblGenome=AGAP001478|UniProtKB=Q7PXM3	AGAP001478-PA	IDA	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00010	B cell activation	P00381	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	ISS	3487386	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00056	VEGF signaling pathway	P01407	Erk	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00318	PKCs	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	BOVIN|Ensembl=ENSBTAG00000014710|UniProtKB=P62833	Ras-related protein Rap-1A	ISS	8576107	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00036	Interleukin signaling pathway	P00965	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IC	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CHLRE|EnsemblGenome=CHLREDRAFT_24392|UniProtKB=A8JAV1	Actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00047	PDGF signaling pathway	P01164	PDK1/2	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	ISS	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00005	Angiogenesis	P00235	c-Fos	RAT|RGD=2626|UniProtKB=P12841	Proto-oncogene c-Fos	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	HUMAN|HGNC=711|UniProtKB=P49407	Beta-arrestin-1	ISS	11742073	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P05916	Opioid prodynorphin pathway	P06002	G-protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	RAT|RGD=61953|UniProtKB=Q64303	Serine/threonine-protein kinase PAK 2	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00060	Ubiquitin proteasome pathway	P01491	E2	PHANO|EnsemblGenome=SNOG_02749|UniProtKB=Q0UZR5	Uncharacterized protein	ISS			PTHR24068:SF74	FI16911P1-RELATED
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	MACMU|Ensembl=ENSMMUG00000010184|UniProtKB=F6SR09	Uncharacterized protein	ISS	14614461	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00046	Oxidative stress response	P01138	MKK4	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04393	Ras Pathway	P04548	ATF2	HUMAN|HGNC=784|UniProtKB=P15336	Cyclic AMP-dependent transcription factor ATF-2	ISS	11390664	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00019	Endothelin signaling pathway	P00589	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	SCHPO|PomBase=SPAC2H10.02c|UniProtKB=O94393	Probable 26S proteasome regulatory subunit p27	ISS			PTHR12651:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	TAS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=1306541|UniProtKB=D3ZVF3	Phosphoinositide-3-kinase, class 2, beta polypeptide (Predicted)	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00046	Oxidative stress response	P01135	p38	DANRE|ZFIN=ZDB-GENE-990415-257|UniProtKB=O42376	Mitogen-activated protein kinase 12	TAS	11707292	PubMed	PTHR24055:SF339	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00021	FGF signaling pathway	P00644	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00199	JNKK1	BOVIN|Ensembl=ENSBTAG00000012103|UniProtKB=A5PJP8	MAP2K4 protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	IDA	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	MACMU|Ensembl=ENSMMUG00000001661|UniProtKB=F7GR69	Uncharacterized protein	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00005	Angiogenesis	P00251	cPLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00021	FGF signaling pathway	P00639	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	10982827	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00049	Parkinson disease	P01219	SAPK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	ORNAN|Ensembl=ENSOANG00000013961|UniProtKB=F6VPY1	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00034	Integrin signalling pathway	P00950	Paxillin	XENTR|Xenbase=XB-GENE-941407|UniProtKB=F7B727	Peroxidasin	ISS	7579684	PubMed	PTHR24216:SF11	PAXILLIN
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00048	PI3 kinase pathway	P01200	SHIP	RAT|RGD=1306168|UniProtKB=D3ZZX1	Inositol polyphosphate-5-phosphatase A (Predicted), isoform CRA_a	ISS			PTHR12997:SF2	TYPE I INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE
P00006	Apoptosis signaling pathway	P00313	IKK	BOVIN|Ensembl=ENSBTAG00000007591|UniProtKB=Q95KV1	Inhibitor of nuclear factor kappa-B kinase subunit alpha	ISS	12235208	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MOUSE|MGI=MGI=2444552|UniProtKB=Q8BFZ3	Beta-actin-like protein 2	ISS	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	DROME|FlyBase=FBgn0260964|UniProtKB=Q8IH57	GH10249p	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P06587	Nicotine pharmacodynamics pathway	P06613	CHRNB2	BOVIN|Ensembl=ENSBTAG00000007517|UniProtKB=F1MUN1	Uncharacterized protein	ISS	22213672	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P00005	Angiogenesis	P00205	GAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	ISS	8262392	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	IDA	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00005	Angiogenesis	P00249	PAK	CHICK|Ensembl=ENSGALG00000008058|UniProtKB=F1N8W8	Uncharacterized protein	ISS	11259591	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00029	Huntington disease	P00798	Clathrin	DROME|FlyBase=FBgn0024814|UniProtKB=Q9VWA1	Clathrin light chain	IDA	9388255	PubMed	PTHR10639:SF7	CLATHRIN LIGHT CHAIN
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000008714|UniProtKB=F7E1N0	Adenosine receptor A1	ISS	12515326	PubMed	PTHR24246:SF1	ADENOSINE RECEPTOR A1
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MOUSE|MGI=MGI=95821|UniProtKB=Q01097	Glutamate receptor ionotropic, NMDA 2B	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P05915	Opioid proenkephalin pathway	P05994	G-protein	ANOGA|EnsemblGenome=AGAP005913|UniProtKB=Q7Q6D2	AGAP005913-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00551	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01219	SAPK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00632	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00017	DNA replication	P00527	Histones	CIOIN|Ensembl=ENSCING00000002753|UniProtKB=F7AHT0	Histone H3	ISS	20448842	PubMed	PTHR11426:SF179	HISTONE H3.3
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	STRPU|EnsemblGenome=SPU_009155|UniProtKB=W4Y0D3	Uncharacterized protein	ISS			PTHR23315:SF233	ARMADILLO SEGMENT POLARITY PROTEIN
P00029	Huntington disease	P00790	beta-Tubulin	PANTR|Ensembl=ENSPTRG00000009878|UniProtKB=H2QEA0	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DROME|FlyBase=FBgn0013343|UniProtKB=Q24547	Syntaxin-1A	ISS	12624525	PubMed	PTHR19957:SF41	SYNTAXIN-1A
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00020	FAS signaling pathway	P00600	PARP	PANTR|Ensembl=ENSPTRG00000002049|UniProtKB=H2Q186	Poly [ADP-ribose] polymerase	ISS	12101391	PubMed	PTHR10459:SF80	POLY  ADP-RIBOSE  POLYMERASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00087	Fe65	BOVIN|Ensembl=ENSBTAG00000015655|UniProtKB=Q17QV1	Amyloid beta (A4) protein-binding, family B, member 1 (Fe65)	ISS	11441186	PubMed	PTHR14058:SF5	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1
P06959	CCKR signaling map	P07110	PLC_beta	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	RCA	16754659	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	12885769	PubMed	PTHR10202:SF13	PRESENILIN-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MACMU|Ensembl=ENSMMUG00000022661|UniProtKB=F7GUA3	C-C chemokine receptor type 4	ISS	11698495	PubMed	PTHR10489:SF608	C-C CHEMOKINE RECEPTOR TYPE 4
P00046	Oxidative stress response	P01126	ATF2	PANTR|Ensembl=ENSPTRG00000012660|UniProtKB=H2QJ07	Activating transcription factor 2	ISS	7875593	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MOUSE|MGI=MGI=108482|UniProtKB=P97292	Histamine H2 receptor	IDA	11841575	PubMed	PTHR43893:SF5	HISTAMINE H2 RECEPTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00030	Hypoxia response via HIF activation	P00819	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00285	Diva	HUMAN|HGNC=993|UniProtKB=Q9HD36	Bcl-2-like protein 10	ISS			PTHR11256:SF47	BCL-2-LIKE PROTEIN 10
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00048	PI3 kinase pathway	P01177	P110ACT	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00385	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12912997	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P05918	p38 MAPK pathway	P06019	ATF1	MOUSE|MGI=MGI=1298366|UniProtKB=P81269	Cyclic AMP-dependent transcription factor ATF-1	ISS	11390664	PubMed	PTHR22952:SF258	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-1
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	LEIMA|EnsemblGenome=LmjF.36.1260|UniProtKB=Q4Q1V0	Fructose-bisphosphate aldolase	ISS	10551371	PubMed	PTHR11627:SF20	FRUCTOSE-BISPHOSPHATE ALDOLASE
P00050	Plasminogen activating cascade	P01250	MMP-13	MACMU|Ensembl=ENSMMUG00000004253|UniProtKB=F6YQ28	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF165	COLLAGENASE 3
P02770	Pyridoxal phosphate salvage pathway	P03120	Pyridoxamine-5-phosphate oxidase	MACMU|Ensembl=ENSMMUG00000003325|UniProtKB=F7EHD9	Pyridoxine-5'-phosphate oxidase	ISS	15182361	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IDA	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00006	Apoptosis signaling pathway	P00274	JNK	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MOUSE|MGI=MGI=1888501|UniProtKB=Q9JJL9	Leukotriene B4 receptor 2	IDA	10934230	PubMed	PTHR24230:SF8	LEUKOTRIENE B4 RECEPTOR 2
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CAEBR|Gene=CBG01555|UniProtKB=A8WRD7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=12782|UniProtKB=P56703	Proto-oncogene Wnt-3	TAS	11266476	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	RAT|RGD=621310|UniProtKB=Q32PX6	Protein Rhog	ISS			PTHR24072:SF158	RHO-RELATED GTP-BINDING PROTEIN RHOG
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	NAS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00081	Pro-BACE-1	BOVIN|Ensembl=ENSBTAG00000019365|UniProtKB=Q2HJ40	Beta-secretase 1	ISS	10956649	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CHLRE|EnsemblGenome=CHLREDRAFT_193901|UniProtKB=Q9FXT7	Mitogen-activated protein kinase	IGI			PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P05917	Opioid proopiomelanocortin pathway	P06011	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=98328|UniProtKB=P30875	Somatostatin receptor type 2	ISS	12562507	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	HALSA|EnsemblGenome=VNG_2384G|UniProtKB=Q9HMU3	Ribonucleoside reductase large chain	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00049	Parkinson disease	P01230	Src kinase	MACMU|Ensembl=ENSMMUG00000017017|UniProtKB=F7FVL2	Tyrosine-protein kinase	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	CANLF|Ensembl=ENSCAFG00000011148|UniProtKB=J9P1Y8	Uncharacterized protein	ISS	9459445	PubMed	PTHR10845:SF170	REGULATOR OF G-PROTEIN SIGNALING 9
P00019	Endothelin signaling pathway	P00577	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00047	PDGF signaling pathway	P01143	ERK	BOVIN|Ensembl=ENSBTAG00000005865|UniProtKB=G5E577	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	TAKRU|Ensembl=ENSTRUG00000011517|UniProtKB=H2TWL9	Uncharacterized protein (Fragment)	ISS	12941441	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00015	Circadian clock system	P00505	Cry	MOUSE|MGI=MGI=1270841|UniProtKB=P97784	Cryptochrome-1	IDA	10217146	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	MOUSE|MGI=MGI=1298218|UniProtKB=O88572	Low-density lipoprotein receptor-related protein 6	IDA	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	MACMU|Ensembl=ENSMMUG00000014498|UniProtKB=F7GEI8	Uncharacterized protein	ISS	8386525	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00018	EGF receptor signaling pathway	P00560	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	IC	2372396	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00897	SHIP2	BOVIN|Ensembl=ENSBTAG00000019167|UniProtKB=E1BBJ7	Uncharacterized protein	ISS	9824312	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P04393	Ras Pathway	P04558	p38	DANRE|ZFIN=ZDB-GENE-990415-257|UniProtKB=O42376	Mitogen-activated protein kinase 12	ISS	11274345	PubMed	PTHR24055:SF339	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00012	Cadherin signaling pathway	P00474	Wnt	MACMU|Ensembl=ENSMMUG00000017345|UniProtKB=F7H9C0	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00036	Interleukin signaling pathway	P00990	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00034	Integrin signalling pathway	P00906	Rap1	ORNAN|Ensembl=ENSOANG00000005936|UniProtKB=F6PQC9	Uncharacterized protein	ISS	10476970	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00056	VEGF signaling pathway	P01417	Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00021	FGF signaling pathway	P00641	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00591	PLCbeta	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00006	Apoptosis signaling pathway	P00321	HSP70	PRIPA|Gene=PPA27506|UniProtKB=H3FYW1	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00029	Huntington disease	P00796	Kainate receptor	BOVIN|Ensembl=ENSBTAG00000033153|UniProtKB=F1MG21	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00049	Parkinson disease	P01241	TH	PANTR|Ensembl=ENSPTRG00000003173|UniProtKB=H2Q2W7	Uncharacterized protein	ISS	12480184	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	BOVIN|Ensembl=ENSBTAG00000020907|UniProtKB=E1BEL5	Uncharacterized protein	ISS	20267852	PubMed	PTHR15938:SF0	HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04397	p53 pathway by glucose deprivation	P04636	S6K	BOVIN|Gene=RPS6KB1|UniProtKB=Q6TJY3	Ribosomal protein S6 kinase beta-1	IDA	11861821	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00005	Angiogenesis	P00220	c-Jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00010	B cell activation	P00379	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IGI	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	BOVIN|Ensembl=ENSBTAG00000011761|UniProtKB=F1MDE1	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05752	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00053	T cell activation	P01307	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	CHICK|Ensembl=ENSGALG00000009927|UniProtKB=Q5ZHX1	Ras-related protein Rap-1b	ISS	1904317	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00021	FGF signaling pathway	P00629	PP2A	MOUSE|MGI=MGI=1917601|UniProtKB=Q8K2V1	Serine/threonine-protein phosphatase 4 regulatory subunit 1	ISS			PTHR10648:SF8	SERINE/THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 1
P00006	Apoptosis signaling pathway	P00261	Bok	CHICK|Gene=BOK|UniProtKB=Q9I8I2	Bcl-2-related ovarian killer protein	IDA	9356461	PubMed	PTHR11256:SF48	BCL-2-RELATED OVARIAN KILLER PROTEIN
P00021	FGF signaling pathway	P00642	MEK1-2	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=1305941|UniProtKB=F1M324	Phosphoinositide phospholipase C	ISS			PTHR10336:SF84	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00899	IRS 1-4	PANTR|Ensembl=ENSPTRG00000012989|UniProtKB=H2QJJ4	Insulin receptor substrate 1	ISS	5031805	gi	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00020	FAS signaling pathway	P00615	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10557357	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00029	Huntington disease	P00808	Caspase 8	MOUSE|MGI=MGI=1261423|UniProtKB=O89110	Caspase-8	IDA	8681376	PubMed	PTHR10454:SF162	CASPASE-8
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00053	T cell activation	P01306	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00030	Hypoxia response via HIF activation	P00819	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DROME|FlyBase=FBgn0030011|UniProtKB=Q9W3J1	Gbeta5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	EMENI|EnsemblGenome=CADANIAG00001443|UniProtKB=P10653	Tubulin beta-1 chain	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00034	Integrin signalling pathway	P00912	Arp2/3	XENTR|Xenbase=XB-GENE-491571|UniProtKB=F6WW07	Uncharacterized protein (Fragment)	ISS	17943202	gi	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00057	Wnt signaling pathway	P01465	Ggamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	SCHPO|PomBase=SPAC17G8.14c|UniProtKB=P36582	Protein kinase C-like 1	TAS	8491190	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04393	Ras Pathway	P04556	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IDA	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00359	NFAT	PANTR|Ensembl=ENSPTRG00000008260|UniProtKB=H2QBD7	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	ISS	9133421	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02726	Aminobutyrate degradation	P02824	Succinate semi-aldehyde dehydrogenase	STRCO|Gene=CAD55522|UniProtKB=Q8CJL1	Succinate-semialdehyde dehydrogenase	ISS	12891648	PubMed	PTHR43353:SF5	SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL
P00029	Huntington disease	P00780	Microtubule	MONDO|Ensembl=ENSMODG00000003363|UniProtKB=F7CB79	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P02721	ATP synthesis	P02798	Cyt C	TAKRU|Ensembl=ENSTRUG00000002170|UniProtKB=H2RXW2	Uncharacterized protein	ISS	5106585	PubMed	PTHR11961:SF12	CYTOCHROME C
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MACMU|Ensembl=ENSMMUG00000014246|UniProtKB=F7C4D3	Uncharacterized protein	ISS	11451570	PubMed	PTHR11848:SF133	INHIBIN BETA A CHAIN
P00010	B cell activation	P00391	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00059	p53 pathway	P01486	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00383	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00009	Axon guidance mediated by netrin	P00359	NFAT	RAT|RGD=1307690|UniProtKB=D4A0I8	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (Predicted), isoform CRA_b	ISS	12787506	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P04393	Ras Pathway	P04558	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IDA	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CHICK|Ensembl=ENSGALG00000009621|UniProtKB=P60706	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00021	FGF signaling pathway	P00624	14-3-3	BOVIN|Ensembl=ENSBTAG00000002108|UniProtKB=Q3SZI4	14-3-3 protein theta	ISS	7603573	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P00021	FGF signaling pathway	P00641	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00021	FGF signaling pathway	P00645	Rac	DICPU|Gene=DICPUDRAFT_168754|UniProtKB=F0ZQR3	Rac1B, RHO family GTPase	ISS	4757952	gi	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00385	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00018	EGF receptor signaling pathway	P00564	Rac	ENTHI|EnsemblGenome=EHI_197840|UniProtKB=C4M8K6	Rho family GTPase	IGI	12932731	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P05913	Enkephalin release	P05974	G-Protein (i)	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	CAEEL|WormBase=WBGene00002335|UniProtKB=P22981	Ras protein let-60	ISS	22022015	PubMed	PTHR24070:SF385	GTPASE HRAS
P00006	Apoptosis signaling pathway	P00273	p53	HUMAN|HGNC=11998|UniProtKB=P04637	Cellular tumor antigen p53	IDA	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000008503|UniProtKB=F6TGJ6	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CAEEL|WormBase=WBGene00001680|UniProtKB=Q20636	Guanine nucleotide-binding protein subunit beta-2	IC	9754712	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00029	Huntington disease	P00777	CBP	ARATH|TAIR=AT1G16710|UniProtKB=Q9FWQ5	Histone acetyltransferase HAC12	IDA	10664585	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00029	Huntington disease	G01535	PIG3	YEAST|SGD=S000000250|UniProtKB=P38230	Probable quinone oxidoreductase	TAS	12932731	PubMed	PTHR42975:SF1	QUINONE OXIDOREDUCTASE-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MONDO|Ensembl=ENSMODG00000016603|UniProtKB=F6ZCX3	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF112	TUBULIN BETA-1 CHAIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	3136397	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	IDA	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00049	Parkinson disease	P01208	Hsp70	DROME|FlyBase=FBgn0051354|UniProtKB=Q9VG58	Major heat shock 70 kDa protein Bbb	IDA	12150907	PubMed	PTHR19375:SF256	HSP70 PROTEIN-RELATED
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00012	Cadherin signaling pathway	P00470	F-actin	XENTR|Xenbase=XB-GENE-490883|UniProtKB=Q6NVA9	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00644	p38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IGI	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00048	PI3 kinase pathway	P01185	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00029	Huntington disease	P00785	Cytochrome c	PANTR|Ensembl=ENSPTRG00000020679|UniProtKB=H2QWV8	Cytochrome c-1	ISS	15163634	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00047	PDGF signaling pathway	P01140	ELK	RAT|RGD=1310504|UniProtKB=B4F7D4	ELK4, member of ETS oncogene family (Predicted)	ISS	11846562	PubMed	PTHR11849:SF21	ETS DOMAIN-CONTAINING PROTEIN ELK-4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00049	Parkinson disease	P01211	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	TAS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04547	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	HUMAN|HGNC=4597|UniProtKB=P41594	Metabotropic glutamate receptor 5	ISS	7476890	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00018	EGF receptor signaling pathway	P00540	MKK3,6	CANLF|Ensembl=ENSCAFG00000018530|UniProtKB=F1PXD3	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00005	Angiogenesis	P00190	RasGAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	ISS	8262392	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	MOUSE|MGI=MGI=1339975|UniProtKB=O88643	Serine/threonine-protein kinase PAK 1	ISS	14580336	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00010	B cell activation	P00381	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04393	Ras Pathway	P04555	PDK	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	IDA	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P02784	Tyrosine biosynthesis	P03213	Aromatic amino acid aminotransferase	PSEAE|EnsemblGenome=PA3139|UniProtKB=P72173	Aspartate aminotransferase	ISS			PTHR11879:SF10	ASPARTATE AMINOTRANSFERASE
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	XENTR|Xenbase=XB-GENE-478121|UniProtKB=F6VPH2	Uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	HUMAN|HGNC=145|UniProtKB=P63267	Actin, gamma-enteric smooth muscle	IC	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	RCA	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=103077|UniProtKB=Q64704	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	BOVIN|Ensembl=ENSBTAG00000011723|UniProtKB=E1BKL6	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	IDA	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	MACMU|Ensembl=ENSMMUG00000007387|UniProtKB=F7E0C1	Protein-serine/threonine kinase	RCA			PTHR24355:SF12	RHODOPSIN KINASE
P05918	p38 MAPK pathway	P06039	MSK2	MOUSE|MGI=MGI=1930076|UniProtKB=Q9Z2B9	Ribosomal protein S6 kinase alpha-4	RCA	6755374	gi	PTHR24351:SF41	RIBOSOMAL PROTEIN S6 KINASE ALPHA-4
P00054	Toll receptor signaling pathway	P01354	NFkappaB	HUMAN|HGNC=9955|UniProtKB=Q04206	Transcription factor p65	ISS	10049353	PubMed	PTHR24169:SF1	TRANSCRIPTION FACTOR P65
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MOUSE|MGI=MGI=1925616|UniProtKB=Q9JMF3	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13	IC	10391901	PubMed	PTHR15936:SF2	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-13
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04398	p53 pathway feedback loops 2	P04651	Ras	CHICK|Ensembl=ENSGALG00000006885|UniProtKB=P08642	GTPase HRas	ISS	87226391	PubMed	PTHR24070:SF385	GTPASE HRAS
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000018372|UniProtKB=F7H1J2	Uncharacterized protein	ISS	11259487	PubMed	PTHR24229:SF1	KAPPA-TYPE OPIOID RECEPTOR
P00012	Cadherin signaling pathway	P00477	GSK3beta	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P06664	Gonadotropin-releasing hormone receptor pathway	P06860	Rac1	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	RCA	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00897	SHIP2	CANLF|Ensembl=ENSCAFG00000005743|UniProtKB=F1PNY0	Uncharacterized protein	ISS	10381377	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P05913	Enkephalin release	P05971	CREB	BOVIN|Gene=CREB1|UniProtKB=P27925	Cyclic AMP-responsive element-binding protein 1	ISS	1354612	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00006	Apoptosis signaling pathway	P00310	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	BOVIN|Gene=MMP9|UniProtKB=P52176	Matrix metalloproteinase-9	TAS	12834808	PubMed	PTHR10201:SF30	MATRIX METALLOPROTEINASE-9
P00048	PI3 kinase pathway	P01189	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00049	Parkinson disease	P01234	GRK	XENTR|Ensembl=ENSXETG00000030841|UniProtKB=F7C5A3	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF18	PROTEIN-SERINE/THREONINE KINASE
P00012	Cadherin signaling pathway	P00462	Casein kinase II	HUMAN|HGNC=2459|UniProtKB=P19784	Casein kinase II subunit alpha'	ISS	10806215	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00034	Integrin signalling pathway	P00922	Collagen	MOUSE|MGI=MGI=88468|UniProtKB=Q01149	Collagen alpha-2(I) chain	IDA	10778855	PubMed	PTHR24023:SF568	COLLAGEN ALPHA-2 I  CHAIN
P00059	p53 pathway	P04623	CBP	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	ISS	9199552	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05918	p38 MAPK pathway	P06031	p38alpha	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	RCA	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	PHYIT|EnsemblGenome=PITG_06376|UniProtKB=D0N4Q3	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta, putative	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01469	Dapper	XENTR|Xenbase=XB-GENE-478639|UniProtKB=Q66KC9	Dapper 1	ISS	11970895	PubMed	PTHR15919:SF12	DAPPER HOMOLOG 1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00013	Cell cycle	P00480	Proteasome	PANTR|Ensembl=ENSPTRG00000009225|UniProtKB=G2HE41	Proteasome (Prosome, macropain) activator subunit 3 (PA28 gamma Ki)	ISS	9218537	PubMed	PTHR10660:SF4	PROTEASOME ACTIVATOR COMPLEX SUBUNIT 3
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	MACMU|Ensembl=ENSMMUG00000005648|UniProtKB=F6W4Y0	Uncharacterized protein	ISS			PTHR43407:SF1	LENGSIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00045	Notch signaling pathway	P01120	NIcs	RAT|RGD=3187|UniProtKB=Q07008	Neurogenic locus notch homolog protein 1	IEP	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00036	Interleukin signaling pathway	P00970	Interleukin	HUMAN|HGNC=5981|UniProtKB=Q16552	Interleukin-17A	IC			PTHR44866:SF1	INTERLEUKIN-17A
P04393	Ras Pathway	P04557	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04393	Ras Pathway	P04567	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000009794|UniProtKB=F6Y049	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF11	PROTOCADHERIN-15
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	ORYSJ|Gene=Os01g0665200|UniProtKB=Q5SN53	Mitogen-activated protein kinase 8	TAS			PTHR24055:SF219	SUBFAMILY NOT NAMED
P00001	Adrenaline and noradrenaline biosynthesis	P00070	VAT2	RAT|RGD=3694|UniProtKB=Q01827	Synaptic vesicular amine transporter	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00010	B cell activation	P00379	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00017	DNA replication	P00534	PCNA	CHICK|Ensembl=ENSGALG00000000169|UniProtKB=Q9DEA3	Proliferating cell nuclear antigen	ISS	12893285	PubMed	PTHR11352:SF0	PROLIFERATING CELL NUCLEAR ANTIGEN
P00029	Huntington disease	P00805	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01428	Frizzled	BOVIN|Ensembl=ENSBTAG00000002107|UniProtKB=A7MB15	FZD1 protein	ISS	12549854	PubMed	PTHR11309:SF81	FRIZZLED-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	HUMAN|HGNC=4597|UniProtKB=P41594	Metabotropic glutamate receptor 5	IDA	12351712	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P02754	Methylcitrate cycle	P03028	Aconitase	XENTR|Xenbase=XB-GENE-1012108|UniProtKB=F7CI44	Aconitate hydratase (Fragment)	ISS			PTHR11670:SF32	CYTOPLASMIC ACONITATE HYDRATASE
P00034	Integrin signalling pathway	P00912	Arp2/3	MOUSE|MGI=MGI=1928375|UniProtKB=Q9JM76	Actin-related protein 2/3 complex subunit 3	ISS	12473693	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00029	Huntington disease	P00774	Dynein complex	HUMAN|HGNC=18745|UniProtKB=Q9Y6G9	Cytoplasmic dynein 1 light intermediate chain 1	IPI	9454836	PubMed	PTHR12688:SF2	CYTOPLASMIC DYNEIN 1 LIGHT INTERMEDIATE CHAIN 1
P00006	Apoptosis signaling pathway	P00307	ELF2alpha	MONDO|Ensembl=ENSMODG00000009911|UniProtKB=F6RU41	Uncharacterized protein	ISS	10889505	PubMed	PTHR10602:SF0	EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12880387	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000009626|UniProtKB=F6ZYQ0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	MACMU|Ensembl=ENSMMUG00000010678|UniProtKB=F7AXI7	Uncharacterized protein	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Gene=GRIK4|UniProtKB=Q5IS46	Glutamate receptor ionotropic, kainate 4	ISS	12778120	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P05912	Dopamine receptor mediated signaling pathway	P05953	EPB41L1	MOUSE|MGI=MGI=103010|UniProtKB=Q9Z2H5	Band 4.1-like protein 1	ISS	12181426	PubMed	PTHR23280:SF24	BAND 4.1-LIKE PROTEIN 1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	PLAF7|EnsemblGenome=PF14_0053|UniProtKB=Q8IM38	Ribonucleotide reductase small subunit	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00054	Toll receptor signaling pathway	P01355	AP1	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P05917	Opioid proopiomelanocortin pathway	P06006	beta-Endorphin	XENTR|Xenbase=XB-GENE-483703|UniProtKB=Q5M8F2	Proopiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00018	EGF receptor signaling pathway	P00545	JNK1-3	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IGI	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01443	Phospholipase C	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00629	PP2A	YEAST|SGD=S000005315|UniProtKB=P32838	Serine/threonine-protein phosphatase PP2A-like PPG1	IGI	7678255	PubMed	PTHR11668:SF25	SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-LIKE PPG1
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00010	B cell activation	P00398	IP3R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04397	p53 pathway by glucose deprivation	P04641	Akt	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00219	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00024	Glycolysis	P00672	Phosphofructokinase-1	HUMAN|HGNC=8877|UniProtKB=P08237	ATP-dependent 6-phosphofructokinase, muscle type	RCA			PTHR13697:SF13	ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE, MUSCLE TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01465	Ggamma	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00059	p53 pathway	G04694	p110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00020	FAS signaling pathway	P00594	Caspase8	MACMU|Ensembl=ENSMMUG00000031296|UniProtKB=F7C587	Uncharacterized protein	ISS	8681376	PubMed	PTHR10454:SF162	CASPASE-8
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	PANTR|Ensembl=ENSPTRG00000014418|UniProtKB=H2QLS0	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00017	DNA replication	P00527	Histones	TRIAD|EnsemblGenome=TriadG24875|UniProtKB=B3RWE2	Histone H3	ISS	20448842	PubMed	PTHR11426:SF20	HISTONE H3-LIKE CENTROMERIC PROTEIN A
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00052	TGF-beta signaling pathway	P01275	P38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	TAS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00556	PLCgamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	IC	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00045	Notch signaling pathway	P01111	LNXp80	PANTR|Ensembl=ENSPTRG00000016062|UniProtKB=H2QPH1	Uncharacterized protein	ISS			PTHR19964:SF14	E3 UBIQUITIN-PROTEIN LIGASE LNX
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	CHICK|Gene=MYH3|UniProtKB=P02565	Myosin-1B	ISS	89264452	PubMed	PTHR13140:SF657	MYOSIN-4
P00005	Angiogenesis	P00203	Erk	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	CANLF|Ensembl=ENSCAFG00000013148|UniProtKB=Q5R1P3	Glutamate receptor ionotropic, NMDA 2B	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=12776|UniProtKB=O96014	Protein Wnt-11	IDA	8717036	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	ARATH|TAIR=AT5G26980|UniProtKB=O65359	Syntaxin-41	IC			PTHR19957:SF83	SYNTAXIN-16
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06798	PKCe/theta	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	RCA	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00057	Wnt signaling pathway	P01437	TCF	HUMAN|HGNC=11641|UniProtKB=Q9NQB0	Transcription factor 7-like 2	IDA	9118222	PubMed	PTHR10373:SF32	TRANSCRIPTION FACTOR 7-LIKE 2
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IDA	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05913	Enkephalin release	P05974	G-Protein (i)	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01435	SWI/SNF	CANLF|Ensembl=ENSCAFG00000016025|UniProtKB=E2QX86	Uncharacterized protein	ISS	11532957	PubMed	PTHR13711:SF206	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY E MEMBER 1
P00029	Huntington disease	P00797	p53	BOVIN|Ensembl=ENSBTAG00000005812|UniProtKB=G3X6J7	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00021	FGF signaling pathway	P00629	PP2A	DANRE|ZFIN=ZDB-GENE-040426-2487|UniProtKB=Q803G3	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P01486	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00056	VEGF signaling pathway	P01420	FAK	PANTR|Ensembl=ENSPTRG00000020624|UniProtKB=H2QWS1	Uncharacterized protein	ISS	9182576	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00018	EGF receptor signaling pathway	P00560	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01219	SAPK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P06959	CCKR signaling map	G06973	FOS	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	RCA	17185632	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00004	Alzheimer disease-presenilin pathway	P00147	TACE	PANTR|Ensembl=ENSPTRG00000011640|UniProtKB=H2R900	Uncharacterized protein	ISS	12834808	PubMed	PTHR11905:SF171	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P05918	p38 MAPK pathway	P05921	MKP5	BOVIN|Ensembl=ENSBTAG00000001729|UniProtKB=Q0IID7	Dual specificity protein phosphatase 10	ISS	11856337	PubMed	PTHR10159:SF299	DUAL SPECIFICITY PROTEIN PHOSPHATASE 10
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MACMU|Ensembl=ENSMMUG00000004253|UniProtKB=F6YQ28	Uncharacterized protein	ISS	Fang,Y.,Kitchell,B.E.,Paria,B.andBalkin,R.	free text	PTHR10201:SF165	COLLAGENASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=94925|UniProtKB=P30728	D(3) dopamine receptor	IDA	2137198	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00023	General transcription regulation	P00666	TFIIE	RAT|RGD=1306851|UniProtKB=G3V992	General transcription factor II E, polypeptide 1 (Alpha subunit)	ISS	189964	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P05915	Opioid proenkephalin pathway	P05993	AC	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	ISS	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	LEIMA|EnsemblGenome=LmjF.35.3960|UniProtKB=E9AFM1	Protein kinase A catalytic subunit isoform 2	IC	14744463	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05916	Opioid prodynorphin pathway	P06002	G-protein	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P05918	p38 MAPK pathway	P06013	ELK	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	RCA	10487205	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P05730	Endogenous cannabinoid signaling	P05751	Galpha	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00541	Spry	HUMAN|HGNC=11270|UniProtKB=O43597	Protein sprouty homolog 2	IGI	12402043	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MONDO|Ensembl=ENSMODG00000023429|UniProtKB=F6XI83	Uncharacterized protein	ISS	12441358	PubMed	PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00048	PI3 kinase pathway	P01192	p110	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00321	HSP70	MONDO|Ensembl=ENSMODG00000019764|UniProtKB=F6WMM9	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00034	Integrin signalling pathway	P00944	Actin	DANRE|ZFIN=ZDB-GENE-000329-1|UniProtKB=Q7ZVI7	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00238	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00036	Interleukin signaling pathway	P00976	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	DROME|FlyBase=FBgn0004647|UniProtKB=P07207	Neurogenic locus Notch protein	IDA	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00034	Integrin signalling pathway	P00938	Cdc42	TAKRU|Ensembl=ENSTRUG00000013411|UniProtKB=H2UB84	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	RAT|RGD=3567|UniProtKB=P49799	Regulator of G-protein signaling 4	ISS	8756726	PubMed	PTHR10845:SF184	REGULATOR OF G-PROTEIN SIGNALING 4
P00056	VEGF signaling pathway	P01422	eNOS	MOUSE|MGI=MGI=97362|UniProtKB=P70313	Nitric oxide synthase, endothelial	ISS	9837777	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P04393	Ras Pathway	P04572	JNK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	ISS	10207617	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00552	Ras	CAEBR|Gene=CBG20938|UniProtKB=A8XZ02	Protein CBR-RAS-1	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00049	Parkinson disease	P01211	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	RAT|RGD=621440|UniProtKB=Q63511	G protein-activated inward rectifier potassium channel 3	IDA	2433589	PubMed	PTHR11767:SF17	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 3
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	MOUSE|MGI=MGI=1351342|UniProtKB=Q3UVX5	Metabotropic glutamate receptor 5	ISS	9407094	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P06217	Toll pathway-drosophila	P06348	SLMB	DROME|Gene=Dmel_CG3412|UniProtKB=A0A0B4KHK1	Supernumerary limbs, isoform B	IDA	9461217	PubMed	PTHR44038:SF2	F-BOX/WD REPEAT-CONTAINING PROTEIN 1A
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=1309878|UniProtKB=D4ACX8	Protocadherin-16	ISS	8120095	PubMed	PTHR43956:SF6	PROTOCADHERIN-16
P00046	Oxidative stress response	P01131	MKP5	MOUSE|MGI=MGI=1914209|UniProtKB=Q9D700	Dual specificity protein phosphatase 26	ISS			PTHR10159:SF112	DUAL SPECIFICITY PROTEIN PHOSPHATASE 26
P00049	Parkinson disease	P01211	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00391	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	ORNAN|Ensembl=ENSOANG00000006877|UniProtKB=F7CQF2	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00021	FGF signaling pathway	P00642	MEK1-2	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	IDA	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	RAT|RGD=3425|UniProtKB=P97887	Presenilin-1	IDA	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00021	FGF signaling pathway	P00638	PLCgamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P02763	Peptidoglycan biosynthesis	P03090	N-Acetylglucosaminyl transferase	BACSU|EnsemblGenome=BSU15220|UniProtKB=P37585	UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase	ISS			PTHR21015:SF22	GLYCOSYLTRANSFERASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHICK|Gene=ACTG2|UniProtKB=P63270	Actin, gamma-enteric smooth muscle	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00036	Interleukin signaling pathway	P00994	FKHRL1	RAT|RGD=1309196|UniProtKB=D3ZBQ1	Forkhead box O3a (Predicted)	ISS	12048180	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P02728	Arginine biosynthesis	P02846	Ornithine carbamoyl transferase	DEIRA|EnsemblGenome=DR_0080|UniProtKB=Q9RY70	Ornithine carbamoyltransferase	ISS			PTHR11405:SF1	ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04546	GSK3	CIOIN|Ensembl=ENSCING00000001821|UniProtKB=Q9NL43	Glycogen synthase kinase	ISS	21361340	gi	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00054	Toll receptor signaling pathway	P01346	TLR	BOVIN|Gene=TLR2|UniProtKB=Q95LA9	Toll-like receptor 2	ISS			PTHR24365:SF17	TOLL-LIKE RECEPTOR 2
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	ORNAN|Ensembl=ENSOANG00000012470|UniProtKB=F7FU89	Uncharacterized protein	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00008	Axon guidance mediated by Slit/Robo	P00355	Rho	BOVIN|Ensembl=ENSBTAG00000014299|UniProtKB=Q1RMJ6	Rho-related GTP-binding protein RhoC	ISS	14871999	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	SCHPO|PomBase=SPBC25D12.04|UniProtKB=P36603	Ribonucleoside-diphosphate reductase small chain	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00021	FGF signaling pathway	P00627	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10755300	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	ORYSJ|EnsemblGenome=OS02G0236000|UniProtKB=Q6EUS6	Aspartate aminotransferase	ISS			PTHR11879:SF18	SUBFAMILY NOT NAMED
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	MONDO|Ensembl=ENSMODG00000005255|UniProtKB=F7G800	Uncharacterized protein	ISS	11259591	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	IDA	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00049	Parkinson disease	P01219	SAPK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	NAS	97102675	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	CIOIN|Ensembl=ENSCING00000007153|UniProtKB=L7N0T1	Uncharacterized protein	ISS			PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00021	FGF signaling pathway	P00645	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00012	Cadherin signaling pathway	P00470	F-actin	HUMAN|HGNC=17780|UniProtKB=Q562R1	Beta-actin-like protein 2	IC	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00053	T cell activation	P01311	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00391	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	CHICK|Ensembl=ENSGALG00000010812|UniProtKB=F1NLZ9	Uncharacterized protein	ISS	15226293	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	RCA	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04542	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	20384797	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01444	Wnt	PANTR|Ensembl=ENSPTRG00000009322|UniProtKB=H2REI3	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF84	PROTEIN WNT-9B
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000007909|UniProtKB=F1MPE9	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00018	EGF receptor signaling pathway	P00547	PP2A	BOVIN|Ensembl=ENSBTAG00000005533|UniProtKB=F1N1S8	Uncharacterized protein	ISS	96161994	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IDA	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	PANTR|Ensembl=ENSPTRG00000012554|UniProtKB=H2QIU8	Receptor protein serine/threonine kinase	ISS	10683140	PubMed	PTHR23255:SF58	ACTIVIN RECEPTOR TYPE-1C
P05918	p38 MAPK pathway	P06034	MKK4	CANLF|Ensembl=ENSCAFG00000017851|UniProtKB=F1PBB6	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P02783	Tryptophan biosynthesis	P03206	Anthranilate synthase	BACSU|EnsemblGenome=BSU00740|UniProtKB=P28820	Aminodeoxychorismate synthase component 1	ISS			PTHR11236:SF23	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01284	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00552	Ras	PANTR|Ensembl=ENSPTRG00000034469|UniProtKB=H2Q2V0	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MACMU|Ensembl=ENSMMUG00000016428|UniProtKB=F7GU00	Metabotropic glutamate receptor 1 isoform alpha	ISS	9407094	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00025	Hedgehog signaling pathway	P00692	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00017	DNA replication	P00534	PCNA	PANTR|Ensembl=ENSPTRG00000013222|UniProtKB=H2QJX3	Proliferating cell nuclear antigen	ISS	12893285	PubMed	PTHR11352:SF0	PROLIFERATING CELL NUCLEAR ANTIGEN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00009	Axon guidance mediated by netrin	P00360	DCC/UNC-40	PANTR|Ensembl=ENSPTRG00000010031|UniProtKB=H2QEJ8	Uncharacterized protein	ISS	8861902	PubMed	PTHR44146:SF3	NETRIN RECEPTOR DCC
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00057	Wnt signaling pathway	P01451	Galpha	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	IDA	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P06664	Gonadotropin-releasing hormone receptor pathway	P06831	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	RCA	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	EMENI|EnsemblGenome=CADANIAG00002670|UniProtKB=Q5BH99	G-protein beta subunit [Source:UniProtKB/TrEMBLAcc:O74214]	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	PLAF7|EnsemblGenome=PFC0520w|UniProtKB=O77345	26S proteasome regulatory subunit RPN12,putative	ISS			PTHR12387:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MACMU|Ensembl=ENSMMUG00000016223|UniProtKB=F7GJM0	Uncharacterized protein	ISS	12356903	PubMed	PTHR11514:SF1	PROTEIN L-MYC-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	TAS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00036	Interleukin signaling pathway	P00970	Interleukin	PANTR|Gene=IL10|UniProtKB=A2T6Z6	Interleukin-10	ISS			PTHR44875:SF1	INTERLEUKIN-10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IDA	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00054	Toll receptor signaling pathway	P01375	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	ISS	12040174	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00045	Notch signaling pathway	P01110	Presenilin	PANTR|Ensembl=ENSPTRG00000006510|UniProtKB=H2Q8K1	Presenilin	ISS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00029	Huntington disease	P00799	JNK-2	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00047	PDGF signaling pathway	P01145	c-fos	PANTR|Ensembl=ENSPTRG00000006553|UniProtKB=A5A6H0	C-fos	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00018	EGF receptor signaling pathway	P00561	STAT	MOUSE|MGI=MGI=103036|UniProtKB=P42230	Signal transducer and activator of transcription 5A	IGI	22320921	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	IC	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00543	ERK1-2	ORYSJ|Gene=Os01g0665200|UniProtKB=Q5SN53	Mitogen-activated protein kinase 8	ISS			PTHR24055:SF219	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00566	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	21150461	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05916	Opioid prodynorphin pathway	P06002	G-protein	XENTR|Xenbase=XB-GENE-6050844|UniProtKB=F6WNJ9	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00005	Angiogenesis	P00217	STAT3	BOVIN|Gene=STAT3|UniProtKB=P61635	Signal transducer and activator of transcription 3	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	TAS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	RAT|RGD=2848|UniProtKB=P08909	5-hydroxytryptamine receptor 2C	ISS	12441358	PubMed	PTHR24247:SF32	5-HYDROXYTRYPTAMINE RECEPTOR 2C
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00034	Integrin signalling pathway	P00916	Ras	YEAST|SGD=S000005627|UniProtKB=P01119	Ras-like protein 1	IPI	7997267	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00024	Glycolysis	P00679	Aldolase	RAT|RGD=2089|UniProtKB=P05065	Fructose-bisphosphate aldolase A	ISS	84261525	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	ANOGA|EnsemblGenome=AGAP009731|UniProtKB=Q7PM77	Protein Wnt	TAS	11266476	PubMed	PTHR12027:SF98	PROTEIN WNT-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00048	PI3 kinase pathway	P01199	Galpha	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00010	B cell activation	P00383	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04393	Ras Pathway	P04544	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	7689150	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00922	Collagen	PANTR|Ensembl=ENSPTRG00000012728|UniProtKB=H2QJ46	Uncharacterized protein	ISS	10778855	PubMed	PTHR24023:SF604	COLLAGEN ALPHA-1 III  CHAIN
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MACMU|Ensembl=ENSMMUG00000004886|UniProtKB=F7AGT9	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CAEEL|WormBase=WBGene00009478|UniProtKB=O62236	SYntaXin	IC	10321247	PubMed	PTHR19957:SF209	LD23667P
P00053	T cell activation	P01315	Calcineurin	CHICK|Ensembl=ENSGALG00000005243|UniProtKB=E1C2T7	Serine/threonine-protein phosphatase	ISS	12091710	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00476	Yes	CHICK|Ensembl=ENSGALG00000014860|UniProtKB=P09324	Tyrosine-protein kinase Yes	ISS	11078745	PubMed	PTHR24418:SF90	TYROSINE-PROTEIN KINASE YES
P00019	Endothelin signaling pathway	P00590	IP3 R	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	IGI	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CHICK|Ensembl=ENSGALG00000015835|UniProtKB=F1NZT2	Uncharacterized protein	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00057	Wnt signaling pathway	P01444	Wnt	RAT|RGD=69250|UniProtKB=Q9QXQ7	Protein Wnt-5a	IDA	8717036	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00010	B cell activation	P00402	Jnk	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00624	14-3-3	MONDO|Ensembl=ENSMODG00000006158|UniProtKB=F7BS95	Uncharacterized protein	ISS	12615066	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IGI	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05731	GABA-B receptor II signaling	P05754	Ggamma	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00054	Toll receptor signaling pathway	P01375	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00019	Endothelin signaling pathway	P00591	PLCbeta	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00049	Parkinson disease	P01208	Hsp70	DROME|FlyBase=FBgn0001218|UniProtKB=P29844	Heat shock 70 kDa protein cognate 3	IDA	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01456	beta-arrestin	ANOGA|Gene=AgaP_AGAP011360|UniProtKB=Q7Q2V9	AGAP011360-PA (Fragment)	IDA	11742073	PubMed	PTHR11792:SF17	KURTZ ARRESTIN
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=2136744|UniProtKB=E9Q5G2	Protein Pcdhb9	IDA	8120095	PubMed	PTHR24028:SF239	PROTEIN PCDHB9
P00034	Integrin signalling pathway	P00944	Actin	XENTR|Xenbase=XB-GENE-490883|UniProtKB=Q6NVA9	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P04395	Vasopressin synthesis	P04589	Signal Peptidase	MONDO|Ensembl=ENSMODG00000003782|UniProtKB=F6RRN6	Uncharacterized protein	ISS	2092035	PubMed	PTHR12804:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 3
P00025	Hedgehog signaling pathway	P00692	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00897	SHIP2	HUMAN|HGNC=6080|UniProtKB=O15357	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	ISS	10610720	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	XENTR|Xenbase=XB-GENE-1010483|UniProtKB=F7AF72	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	HUMAN|HGNC=3373|UniProtKB=Q09472	Histone acetyltransferase p300	ISS	10664585	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	DROME|FlyBase=FBgn0010399|UniProtKB=Q24418	Glutamate [NMDA] receptor subunit 1	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00049	Parkinson disease	P01212	p38 MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P06664	Gonadotropin-releasing hormone receptor pathway	P06738	PLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	RCA	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=96276|UniProtKB=Q61224	5-hydroxytryptamine receptor 1D	IDA	12181435	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P02755	Methylmalonyl pathway	P03033	Propionyl-CoA carboxylase	CAEEL|WormBase=WBGene00017864|UniProtKB=Q19842	Propionyl-CoA carboxylase alpha chain, mitochondrial	ISS			PTHR18866:SF104	PROPIONYL-COA CARBOXYLASE ALPHA CHAIN, MITOCHONDRIAL
P00056	VEGF signaling pathway	P01425	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	MOUSE|MGI=MGI=109482|UniProtKB=P97445	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	14624853	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PRIPA|Gene=PPA17339|UniProtKB=H3F5B4	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF352	ACTIN
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000017387|UniProtKB=E2RLD1	Uncharacterized protein	ISS	129387	gi	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00057	Wnt signaling pathway	P01443	Phospholipase C	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IDA	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	RAT|RGD=621789|UniProtKB=P70539	Activin receptor type-1C	TAS	10683140	PubMed	PTHR23255:SF58	ACTIVIN RECEPTOR TYPE-1C
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	STRPU|EnsemblGenome=SPU_007013|UniProtKB=Q964G0	Cyclin D	IEP	12356903	PubMed	PTHR10177:SF246	CYCLIN D, ISOFORM D
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	9860142	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00029	Huntington disease	P00807	Actin	BOVIN|Gene=ACTB|UniProtKB=P60712	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00029	Huntington disease	P00778	NMDA receptor	HUMAN|HGNC=4588|UniProtKB=O15399	Glutamate receptor ionotropic, NMDA 2D	IDA	14698601	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00004	Alzheimer disease-presenilin pathway	P00114	actin	XENTR|Xenbase=XB-GENE-480347|UniProtKB=Q6P640	Actin, alpha cardiac muscle 1	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	PANTR|Ensembl=ENSPTRG00000005632|UniProtKB=H2Q772	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF86	FRIZZLED-10
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04626	GADD45	MOUSE|MGI=MGI=1346325|UniProtKB=Q9Z111	Growth arrest and DNA damage-inducible protein GADD45 gamma	IGI	10097101	PubMed	PTHR10411:SF4	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 GAMMA
P00029	Huntington disease	P00786	ARF	BOVIN|Ensembl=ENSBTAG00000011883|UniProtKB=Q2YDM1	ADP-ribosylation factor-like protein 1	ISS	12932731	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00029	Huntington disease	P00780	Microtubule	SCHMA|EnsemblGenome=Smp_079960|UniProtKB=G4VTA4	Putative tubulin beta chain	ISS	12932731	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00778	NMDA receptor	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	IDA	11554549	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	HUMAN|HGNC=2455|UniProtKB=P78368	Casein kinase I isoform gamma-2	IDA	10617630	PubMed	PTHR11909:SF157	CASEIN KINASE I ISOFORM GAMMA-2
P00056	VEGF signaling pathway	P01423	p38MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	PLAF7|EnsemblGenome=PFD0830w|UniProtKB=Q8I1R6	Bifunctional dihydrofolate reductase-thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00021	FGF signaling pathway	P00626	Spry	PANTR|Ensembl=ENSPTRG00000005951|UniProtKB=H2Q7P2	Sprouty homolog 2	ISS	12402043	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P00046	Oxidative stress response	P01129	JNK1/2	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	DROME|FlyBase=FBgn0004915|UniProtKB=P29052	Transcription initiation factor IIB	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P00059	p53 pathway	P01485	p53	BOVIN|Ensembl=ENSBTAG00000001069|UniProtKB=P67939	Cellular tumor antigen p53	TAS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00056	VEGF signaling pathway	P01417	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01275	P38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	TAS	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P02723	Adenine and hypoxanthine salvage pathway	P02809	Xanthine dehydrogenase	HUMAN|HGNC=12805|UniProtKB=P47989	Xanthine dehydrogenase/oxidase	ISS	11307944	PubMed	PTHR11908:SF80	XANTHINE DEHYDROGENASE/OXIDASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	HUMAN|HGNC=1392|UniProtKB=Q15878	Voltage-dependent R-type calcium channel subunit alpha-1E	IDA	8386525	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00034	Integrin signalling pathway	P00947	Laminin	MOUSE|MGI=MGI=99915|UniProtKB=Q61087	Laminin subunit beta-3	IPI	2538453	PubMed	PTHR10574:SF268	LAMININ SUBUNIT BETA-3
P00057	Wnt signaling pathway	P01438	PP2A	RAT|RGD=3380|UniProtKB=P63331	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	IDA	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00056	VEGF signaling pathway	P01407	Erk	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	STRPU|EnsemblGenome=SPU_026078|UniProtKB=W4ZD41	Uncharacterized protein	IDA	11889126	PubMed	PTHR11937:SF277	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DANRE|ZFIN=ZDB-GENE-041001-104|UniProtKB=Q5TZD4	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	ANOGA|EnsemblGenome=AGAP005912|UniProtKB=Q7Q6D3	AGAP005912-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00012	Cadherin signaling pathway	P00470	F-actin	MOUSE|MGI=MGI=87909|UniProtKB=P62737	Actin, aortic smooth muscle	IC	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P04393	Ras Pathway	P04558	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	IDA	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00255	Notch	MACMU|Ensembl=ENSMMUG00000017022|UniProtKB=F7HQZ9	Uncharacterized protein	ISS	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	RAT|RGD=628852|UniProtKB=Q02294	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	14507926	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00005	Angiogenesis	P00184	Src	MOUSE|MGI=MGI=98397|UniProtKB=P05480	Neuronal proto-oncogene tyrosine-protein kinase Src	ISS	11078745	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00029	Huntington disease	P00805	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02723	Adenine and hypoxanthine salvage pathway	P02808	Deoxyadenosine phosphorylase	STRCO|Gene=CAD30908|UniProtKB=Q9EWV2	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IPI	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05915	Opioid proenkephalin pathway	P05985	Mu or Delta receptor	HUMAN|HGNC=8153|UniProtKB=P41143	Delta-type opioid receptor	RCA	12093103	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IC	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00005	Angiogenesis	P00194	Paxillin	RAT|RGD=1304981|UniProtKB=Q5M852	Leupaxin	ISS			PTHR24216:SF23	LEUPAXIN
P00012	Cadherin signaling pathway	P00470	F-actin	DANRE|ZFIN=ZDB-GENE-050417-267|UniProtKB=F1QUN8	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF263	ACTIN
P04393	Ras Pathway	P04572	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00559	MEK1-2	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00627	ERK1-2	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	RAT|RGD=621375|UniProtKB=Q9QY78	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000010526|UniProtKB=F7B1S0	Uncharacterized protein	ISS			PTHR11824:SF7	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00057	Wnt signaling pathway	P01447	Dishevelled	CIOIN|Ensembl=ENSCING00000009658|UniProtKB=Q9NL46	Dishevelled homolog	ISS	7906389	PubMed	PTHR10878:SF25	SEGMENT POLARITY PROTEIN DISHEVELLED
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	TAKRU|Ensembl=ENSTRUG00000011655|UniProtKB=H2TXP5	Uncharacterized protein	ISS	11679592	PubMed	PTHR23122:SF40	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT1G59580|UniProtKB=Q39022	Mitogen-activated protein kinase 2	IDA	10851062	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00020	FAS signaling pathway	P00610	MKK4	BOVIN|Ensembl=ENSBTAG00000012103|UniProtKB=A5PJP8	MAP2K4 protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00006	Apoptosis signaling pathway	P00260	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	ANOGA|Gene=AgaP_AGAP009115|UniProtKB=Q7PW25	Phosphoinositide phospholipase C (Fragment)	ISS	12860966	PubMed	PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00015	Circadian clock system	G01499	per	MACMU|Ensembl=ENSMMUG00000018930|UniProtKB=F6YLJ6	Uncharacterized protein	ISS	11232563	PubMed	PTHR11269:SF9	PERIOD CIRCADIAN PROTEIN HOMOLOG 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	ISS	14526383	PubMed	PTHR10048:SF14	PI-3 KINASE
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00778	NMDA receptor	CAEEL|WormBase=WBGene00003774|UniProtKB=G5EGQ9	NMDA class glutamate Receptor	IDA	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	CANLF|Ensembl=ENSCAFG00000002292|UniProtKB=E2RPI9	Uncharacterized protein	ISS	9388255	PubMed	PTHR10639:SF1	CLATHRIN LIGHT CHAIN A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CHICK|Ensembl=ENSGALG00000008512|UniProtKB=F1P0S6	Uncharacterized protein	ISS	20112749	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00057	Wnt signaling pathway	P01447	Dishevelled	BOVIN|Ensembl=ENSBTAG00000019336|UniProtKB=F1MMW6	Uncharacterized protein	ISS	10409711	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	ISS	12488551	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g188243|UniProtKB=A7SCN8	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04398	p53 pathway feedback loops 2	P04658	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00938	Cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00012	Cadherin signaling pathway	P00476	Yes	MONDO|Ensembl=ENSMODG00000021477|UniProtKB=F7G374	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF90	TYROSINE-PROTEIN KINASE YES
P00018	EGF receptor signaling pathway	P00543	ERK1-2	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IGI	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	CHICK|Ensembl=ENSGALG00000007509|UniProtKB=F1NM72	Uncharacterized protein	ISS	6309844	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P01480	PTEN	TAKRU|Ensembl=ENSTRUG00000009851|UniProtKB=H2TJ90	Uncharacterized protein	IGI	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	MOUSE|MGI=MGI=106217|UniProtKB=Q61290	Voltage-dependent R-type calcium channel subunit alpha-1E	IDA	14507926	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00048	PI3 kinase pathway	P01194	S6K	MONDO|Ensembl=ENSMODG00000014313|UniProtKB=F7BTW0	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00034	Integrin signalling pathway	P00922	Collagen	HUMAN|HGNC=2215|UniProtKB=P27658	Collagen alpha-1(VIII) chain	IDA	10778855	PubMed	PTHR44057:SF2	COLLAGEN ALPHA-1 VIII  CHAIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	DANRE|ZFIN=ZDB-GENE-040625-167|UniProtKB=Q6IQP4	RAP1A, member of RAS oncogene family	ISS	1904317	PubMed	PTHR24070:SF284	RAP1A, MEMBER OF RAS ONCOGENE FAMILY
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	CANLF|Ensembl=ENSCAFG00000005035|UniProtKB=F1PGW4	Serine/threonine-protein kinase receptor	ISS	11252892	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	BOVIN|Ensembl=ENSBTAG00000009778|UniProtKB=E1BMX0	Uncharacterized protein	ISS	9869449	PubMed	PTHR24070:SF186	GTPASE KRAS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	ISS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00053	T cell activation	P01306	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IDA	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P00006	Apoptosis signaling pathway	P00274	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00005	Angiogenesis	P00212	EphR	MACMU|Ensembl=ENSMMUG00000008242|UniProtKB=F7HDY6	Uncharacterized protein	ISS			PTHR24416:SF18	EPHRIN TYPE-A RECEPTOR 3
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=1561991|UniProtKB=A0A096MJW8	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF51	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-1
P00036	Interleukin signaling pathway	P00990	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02740	De novo pyrimidine ribonucleotides biosythesis	P02928	Dihydroorotase	PYRAE|EnsemblGenome=PAE0322|UniProtKB=Q8ZZC7	Dihydroorotase	ISS			PTHR43668:SF2	ALLANTOINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01084	CHT1	RHOBA|EnsemblGenome=RB8472|UniProtKB=Q7UFM6	High affinity choline transporter	RCA			PTHR43291:SF6	SUBFAMILY NOT NAMED
P06587	Nicotine pharmacodynamics pathway	P06602	PPP1CA	MOUSE|MGI=MGI=103016|UniProtKB=P62137	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit	TAS	8392016	PubMed	PTHR11668:SF377	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-ALPHA CATALYTIC SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	CHICK|Ensembl=ENSGALG00000001884|UniProtKB=F1NF49	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF138	MATRIX METALLOPROTEINASE-24
P00018	EGF receptor signaling pathway	P00551	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IGI	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00586	Gq	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00623	FGF	HUMAN|HGNC=3665|UniProtKB=P05230	Fibroblast growth factor 1	IGI	12057924	PubMed	PTHR11486:SF86	FIBROBLAST GROWTH FACTOR 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MOUSE|MGI=MGI=104618|UniProtKB=P51675	C-C chemokine receptor type 1	IDA	9329966	PubMed	PTHR10489:SF711	C-C CHEMOKINE RECEPTOR TYPE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000013587|UniProtKB=F7AZ16	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF33	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-3
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	PANTR|Ensembl=ENSPTRG00000016800|UniProtKB=H2QQS3	Solute carrier family 1 (Glial high affinity glutamate transporter), member 3	ISS	94365697	PubMed	PTHR11958:SF24	EXCITATORY AMINO ACID TRANSPORTER 1
P04393	Ras Pathway	P04552	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	CANLF|Ensembl=ENSCAFG00000015156|UniProtKB=E2RH37	GTP:AMP phosphotransferase AK3, mitochondrial	ISS			PTHR23359:SF68	GTP:AMP PHOSPHOTRANSFERASE AK3, MITOCHONDRIAL
P02757	O-antigen biosynthesis	P03046	dTDP-glucose pyrophosphorylase	ECOLI|EcoGene=EG11978|UniProtKB=P37744	Glucose-1-phosphate thymidylyltransferase 1	ISS			PTHR43532:SF1	GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	8787761	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00010	B cell activation	P00371	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01212	p38 MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05912	Dopamine receptor mediated signaling pathway	P05949	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	9763606	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=2685369|UniProtKB=Q5F226	Protocadherin Fat 2	ISS	8120095	PubMed	PTHR24026:SF37	PROTOCADHERIN FAT 2
P00029	Huntington disease	P00807	Actin	MONBE|Gene=37852|UniProtKB=A9V489	Predicted protein	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00217	STAT3	CANLF|Ensembl=ENSCAFG00000015213|UniProtKB=E2RB82	Signal transducer and activator of transcription	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00009	Axon guidance mediated by netrin	P00356	UNC-5	RAT|RGD=621755|UniProtKB=O08721	Netrin receptor UNC5A	ISS			PTHR12582:SF4	NETRIN RECEPTOR UNC5A
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00057	Wnt signaling pathway	P01443	Phospholipase C	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	IDA	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00005	Angiogenesis	P00217	STAT3	CANLF|Ensembl=ENSCAFG00000015213|UniProtKB=E2RB82	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	DANRE|ZFIN=ZDB-GENE-070410-56|UniProtKB=F1QHE5	Uncharacterized protein	ISS			PTHR10410:SF5	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 14
P00056	VEGF signaling pathway	P01407	Erk	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02723	Adenine and hypoxanthine salvage pathway	P02807	Deoxyadenosine deaminase	STRCO|EnsemblGenome=CAB66224|UniProtKB=Q9RDE5	Adenine deaminase	ISS			PTHR43114:SF2	ADENINE DEAMINASE
P00019	Endothelin signaling pathway	P00590	IP3 R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	HUMAN|HGNC=144|UniProtKB=P63261	Actin, cytoplasmic 2	IC	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00005	Angiogenesis	P00193	SOS-1	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IDA	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00018	EGF receptor signaling pathway	P00546	GAP	HUMAN|HGNC=23181|UniProtKB=O43374	Ras GTPase-activating protein 4	ISS	6635197	gi	PTHR10194:SF4	RAS GTPASE-ACTIVATING PROTEIN 4-RELATED
P05913	Enkephalin release	P05972	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	XENTR|Xenbase=XB-GENE-491938|UniProtKB=Q6DIV8	Actin, alpha 1, skeletal muscle	ISS	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00029	Huntington disease	P00807	Actin	YARLI|EnsemblGenome=YALI0_D08272g|UniProtKB=Q9UVF3	Actin	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=3020|UniProtKB=P21728	D(1A) dopamine receptor	IDA			PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DANRE|ZFIN=ZDB-GENE-040426-1178|UniProtKB=Q7SY24	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00038	JAK/STAT signaling pathway	P01027	STAT	TAKRU|Ensembl=ENSTRUG00000015348|UniProtKB=H2UQK9	Signal transducer and activator of transcription	ISS	15452141	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00057	Wnt signaling pathway	P01443	Phospholipase C	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00010	B cell activation	P00381	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IGI	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01129	JNK1/2	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	RCA	8787761	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=17175|UniProtKB=Q9P212	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	12860966	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	MACMU|Ensembl=ENSMMUG00000015925|UniProtKB=F7AL30	Protein-serine/threonine kinase	ISS	10852916	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	HUMAN|HGNC=1462|UniProtKB=Q13557	Calcium/calmodulin-dependent protein kinase type II subunit delta	ISS	12888804	PubMed	PTHR43940:SF4	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT DELTA
P00047	PDGF signaling pathway	P01173	STAT	BOVIN|Gene=STAT5B|UniProtKB=Q9TUM3	Signal transducer and activator of transcription 5B	ISS	96210005	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	PANTR|Ensembl=ENSPTRG00000004233|UniProtKB=H2Q4N9	Uncharacterized protein	ISS	12497607	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	BOVIN|Ensembl=ENSBTAG00000005464|UniProtKB=E1B9K3	Uncharacterized protein	ISS	92357702	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00007	Axon guidance mediated by semaphorins	P00340	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00034	Integrin signalling pathway	P00936	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DICDI|dictyBase=DDB_G0268622|UniProtKB=P34145	Rho-related protein rac1B	ISS	21127961	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00050	Plasminogen activating cascade	P01258	Fibrin C-terminal truncation	RAT|RGD=2603|UniProtKB=P06399	Fibrinogen alpha chain	ISS	87134033	PubMed	PTHR19143:SF232	FIBRINOGEN ALPHA CHAIN
P00047	PDGF signaling pathway	P01151	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00019	Endothelin signaling pathway	P00590	IP3 R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	SCHPO|PomBase=SPCC576.15c|UniProtKB=Q12701	Serine/threonine-protein kinase ksg1	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00016	Cytoskeletal regulation by Rho GTPase	P00508	Cofilin	YEAST|SGD=S000003973|UniProtKB=Q03048	Cofilin	ISS			PTHR11913:SF12	CFL1 PROTEIN-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	DANRE|ZFIN=ZDB-GENE-050417-59|UniProtKB=Q15KE4	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00021	FGF signaling pathway	P00624	14-3-3	PANTR|Ensembl=ENSPTRG00000011641|UniProtKB=H2QHF1	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	ISS	7603573	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	IDA	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MOUSE|MGI=MGI=88396|UniProtKB=P12657	Muscarinic acetylcholine receptor M1	TAS	10069496	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00059	p53 pathway	G04694	p110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=4594|UniProtKB=Q14416	Metabotropic glutamate receptor 2	IDA	12351712	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00021	FGF signaling pathway	P00636	FGFR1-4	CHICK|Gene=FGFR2|UniProtKB=P18461	Fibroblast growth factor receptor 2	ISS	14507786	PubMed	PTHR24416:SF130	FIBROBLAST GROWTH FACTOR RECEPTOR 2
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	DROME|FlyBase=FBgn0019947|UniProtKB=O02194	Presenilin homolog	IDA	12369105	PubMed	PTHR10202:SF13	PRESENILIN-2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	TAKRU|Ensembl=ENSTRUG00000007989|UniProtKB=P68140	Actin, alpha skeletal muscle A	IDA	10974003	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00094	BACE-1 pro-domain	MOUSE|MGI=MGI=1346542|UniProtKB=P56818	Beta-secretase 1	IDA	10531052	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00034	Integrin signalling pathway	P00924	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Ensembl=ENSCAFG00000004256|UniProtKB=E2RR18	Serine/threonine-protein kinase	ISS	11062248	PubMed	PTHR22968:SF12	SERINE/THREONINE-PROTEIN KINASE D2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02721	ATP synthesis	P02794	F1 beta	MACMU|Ensembl=ENSMMUG00000030356|UniProtKB=F7F3I6	ATP synthase subunit beta	ISS	2896550	PubMed	PTHR15184:SF44	ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	DICDI|dictyBase=DDB_G0279413|UniProtKB=P05987	cAMP-dependent protein kinase regulatory subunit	ISS	92186968	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00627	ERK1-2	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P05915	Opioid proenkephalin pathway	P05995	proenkephalin	RAT|RGD=68946|UniProtKB=P04094	Proenkephalin-A	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00051	TCA cycle	P01273	Succinate Dehydrogenase	MACMU|Ensembl=ENSMMUG00000012411|UniProtKB=F6TRE8	Uncharacterized protein	ISS	11897817	PubMed	PTHR10978:SF3	SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL
P00019	Endothelin signaling pathway	P00566	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	RAT|RGD=3238|UniProtKB=P01179	Oxytocin-neurophysin 1	ISS	192340	OMIM	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00046	Oxidative stress response	P01135	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	TAS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00016	Cytoskeletal regulation by Rho GTPase	P00509	Slingshot	MACMU|Ensembl=ENSMMUG00000015107|UniProtKB=F6WNH3	Uncharacterized protein	ISS			PTHR10159:SF138	PROTEIN PHOSPHATASE SLINGSHOT HOMOLOG 1
P00018	EGF receptor signaling pathway	P00562	p38	CAEEL|WormBase=WBGene00004055|UniProtKB=Q17446	Mitogen-activated protein kinase pmk-1	IGI	10851062	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00019	Endothelin signaling pathway	P00570	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	ARATH|TAIR=AT3G02160|UniProtKB=Q9S7R9	At3g02160	ISS	604903	OMIM	PTHR12321:SF53	BROMODOMAIN TRANSCRIPTION FACTOR
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	PANTR|Ensembl=ENSPTRG00000008175|UniProtKB=H2RA57	Uncharacterized protein	ISS	10806215	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00019	Endothelin signaling pathway	P00574	Big ET1-4	MACMU|Ensembl=ENSMMUG00000007263|UniProtKB=F7FGG2	Preproendothelin-1	ISS	12907686	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00570	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000015717|UniProtKB=F6SFA9	Serotonin receptor type 1B	ISS	12441358	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00020	FAS signaling pathway	P00601	c-Jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00048	PI3 kinase pathway	P01188	Gbetagamma	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00012	Cadherin signaling pathway	P00477	GSK3beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00015	Circadian clock system	P00505	Cry	CHICK|Gene=CRY1|UniProtKB=Q8QG61	Cryptochrome-1	ISS			PTHR11455:SF16	CRYPTOCHROME-1
P00048	PI3 kinase pathway	P01177	P110ACT	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01443	Phospholipase C	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	IDA	88311074	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00053	T cell activation	P01318	PKC-theta	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00035	Interferon-gamma signaling pathway	P00959	IFNGR1	PANTR|Ensembl=ENSPTRG00000013868|UniProtKB=H2QKZ0	Interferon gamma receptor 2 (Interferon gamma transducer 1)	ISS			PTHR20859:SF46	INTERFERON GAMMA RECEPTOR 2
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	MACMU|Ensembl=ENSMMUG00000013927|UniProtKB=F6SMC2	Uncharacterized protein	ISS	11313498	gi	PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000024633|UniProtKB=F1MBU9	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	DICPU|Gene=DICPUDRAFT_57324|UniProtKB=F0ZVH9	Putative uncharacterized protein rasS	ISS	94119591	PubMed	PTHR24070:SF380	RAS-LIKE PROTEIN RASS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	ISS	1504106	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04544	Grb2	XENTR|Xenbase=XB-GENE-6070000|UniProtKB=Q66II3	Growth factor receptor-bound protein 2	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00036	Interleukin signaling pathway	P00994	FKHRL1	MACMU|Ensembl=ENSMMUG00000020369|UniProtKB=F6UMX8	Uncharacterized protein	ISS	14775847	gi	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00005	Angiogenesis	P00193	SOS-1	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00036	Interleukin signaling pathway	P00981	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	RCA	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	MOUSE|MGI=MGI=99659|UniProtKB=E9PZQ0	Ryanodine receptor 1	ISS	15858232	PubMed	PTHR13715:SF15	RYANODINE RECEPTOR 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01437	TCF	MOUSE|MGI=MGI=96770|UniProtKB=P27782	Lymphoid enhancer-binding factor 1	IDA	11266476	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	15313841	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00048	PI3 kinase pathway	P01181	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02748	Isoleucine biosynthesis	P02994	Branched chain amino acid aminotransferase	ARATH|TAIR=AT1G50110|UniProtKB=Q9LPM9	Branched-chain-amino-acid aminotransferase 6	ISS			PTHR42825:SF4	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 6-RELATED
P00005	Angiogenesis	P00187	beta catenin	MONDO|Ensembl=ENSMODG00000011192|UniProtKB=F6SRK5	Uncharacterized protein	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00006	Apoptosis signaling pathway	P00274	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00168	E-cadherin intracellular fragment	MACMU|Ensembl=ENSMMUG00000010393|UniProtKB=F7D992	Uncharacterized protein	ISS	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P00047	PDGF signaling pathway	P01173	STAT	BOVIN|Gene=STAT5B|UniProtKB=Q9TUM3	Signal transducer and activator of transcription 5B	ISS	22320921	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00036	Interleukin signaling pathway	P00965	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00024	Glycolysis	P00671	Phosphoglycerate kinase	METAC|EnsemblGenome=MA_3592|UniProtKB=Q8TK32	Phosphoglycerate kinase 2	ISS	22120827	PubMed	PTHR11406:SF0	PHOSPHOGLYCERATE KINASE
P05918	p38 MAPK pathway	P06021	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	10802295	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00005	Angiogenesis	P00193	SOS-1	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P05918	p38 MAPK pathway	P06025	SRF	MONDO|Ensembl=ENSMODG00000018981|UniProtKB=F7FP88	Uncharacterized protein	ISS	15170389	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00029	Huntington disease	P00807	Actin	CRYNJ|EnsemblGenome=CNA04650|UniProtKB=Q5KP06	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05915	Opioid proenkephalin pathway	P05989	leu-Enkephalin	PANTR|Ensembl=ENSPTRG00000020270|UniProtKB=H2QW70	Proenkephalin	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000007882|UniProtKB=G3X7Z2	Uncharacterized protein	ISS	8386525	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P05918	p38 MAPK pathway	P06034	MKK4	PANTR|Ensembl=ENSPTRG00000008783|UniProtKB=H2QCA7	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	15313841	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	MOUSE|MGI=MGI=95814|UniProtKB=Q60934	Glutamate receptor ionotropic, kainate 1	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8698|UniProtKB=Q9Y5H2	Protocadherin gamma-A11	IDA	8120095	PubMed	PTHR24028:SF84	PROTOCADHERIN GAMMA-A11
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MONDO|Ensembl=ENSMODG00000020204|UniProtKB=F6SED9	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P04393	Ras Pathway	P04553	PAK	CHICK|Ensembl=ENSGALG00000000681|UniProtKB=E1C3P6	Uncharacterized protein	ISS	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	PANTR|Gene=HTR1E|UniProtKB=Q9N2B6	5-hydroxytryptamine receptor 1E (Fragment)	ISS	1608964	PubMed	PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000013587|UniProtKB=F7AZ16	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF33	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-3
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	ISS	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00923	Arf1	DANRE|ZFIN=ZDB-GENE-040718-175|UniProtKB=Q6DGK1	Uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00048	PI3 kinase pathway	P01196	PDK1	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	IDA	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02769	Purine metabolism	P03119	5'-Nucleotidase	MOUSE|MGI=MGI=99782|UniProtKB=Q61503	5'-nucleotidase	NAS	8224905	PubMed	PTHR11575:SF25	5'-NUCLEOTIDASE
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05726	2-arachidonoylglycerol biosynthesis	P05736	DGL	HUMAN|HGNC=1165|UniProtKB=Q9Y4D2	Sn1-specific diacylglycerol lipase alpha	IDA			PTHR21493:SF164	SN1-SPECIFIC DIACYLGLYCEROL LIPASE ALPHA
P00056	VEGF signaling pathway	P01407	Erk	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P02738	De novo purine biosynthesis	P02909	GDP reductase	SYNY3|EnsemblGenome=BAA18334|UniProtKB=P74240	Ribonucleoside-diphosphate reductase subunit alpha	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	TAS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	MOUSE|MGI=MGI=109482|UniProtKB=P97445	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	IDA	11976940	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00057	Wnt signaling pathway	P01448	CBP	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00018	EGF receptor signaling pathway	P00565	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00878	INFgamma	HUMAN|HGNC=5438|UniProtKB=P01579	Interferon gamma	TAS	11929133	PubMed	PTHR11419:SF0	INTERFERON GAMMA
P02751	Lysine biosynthesis	P03007	Diaminopimelate decarboxylase	METAC|EnsemblGenome=MA_0726|UniProtKB=Q8TSR9	Diaminopimelate decarboxylase	ISS			PTHR43727:SF2	DIAMINOPIMELATE DECARBOXYLASE 1, CHLOROPLASTIC-RELATED
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00059	p53 pathway	P04626	GADD45	BOVIN|Ensembl=ENSBTAG00000003033|UniProtKB=Q2KIX1	Growth arrest and DNA damage-inducible protein GADD45 gamma	ISS	10097101	PubMed	PTHR10411:SF4	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 GAMMA
P00056	VEGF signaling pathway	P01417	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	15531926	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=1748|UniProtKB=P12830	Cadherin-1	IDA	11953314	PubMed	PTHR24027:SF319	CADHERIN-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000001867|UniProtKB=H2Q0X8	Adenosine receptor A1	ISS	12106606	PubMed	PTHR24246:SF1	ADENOSINE RECEPTOR A1
P00047	PDGF signaling pathway	P01152	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02783	Tryptophan biosynthesis	P03208	Tryptophan synthase B	EMENI|EnsemblGenome=CADANIAG00006763|UniProtKB=Q5AZP9	Bifunctional tryptophan synthase TRPB (EC 4.2.1.20) [Source:UniProtKB/TrEMBLAcc:Q9P4D5]	ISS			PTHR42882:SF1	TRYPTOPHAN SYNTHASE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=11438|UniProtKB=Q13277	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	PANTR|Ensembl=ENSPTRG00000011049|UniProtKB=H2QGF9	Glycogen synthase kinase 3 alpha	ISS	14698990	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00059	p53 pathway	G04702	p53	PANTR|Ensembl=ENSPTRG00000008703|UniProtKB=H2QC53	Cellular tumor antigen p53	ISS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00006	Apoptosis signaling pathway	P00269	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	97102671	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00645	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00021	FGF signaling pathway	P00627	ERK1-2	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00054	Toll receptor signaling pathway	P01355	AP1	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00049	Parkinson disease	P01236	Casein kinase II	DANRE|ZFIN=ZDB-GENE-990415-28|UniProtKB=Q7ZU33	Ck2a2 protein	IDA	10806215	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	RCA			PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P02773	S-adenosylmethionine biosynthesis	P03142	Cobalamin-dependent homocysteine transmethylase	CANLF|Ensembl=ENSCAFG00000010464|UniProtKB=E2R716	Uncharacterized protein	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P00018	EGF receptor signaling pathway	P00558	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	HALSA|EnsemblGenome=VNG_1089G|UniProtKB=Q9HQM6	Adenylosuccinate synthetase	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00047	PDGF signaling pathway	P01160	IP3 receptor	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00015	Circadian clock system	G01501	cry	MONDO|Ensembl=ENSMODG00000001579|UniProtKB=F7BWW8	Uncharacterized protein	ISS	14507900	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P02724	Alanine biosynthesis	P02815	Branched chain amino acid aminotransferase	METJA|EnsemblGenome=MJ_1008|UniProtKB=Q58414	Putative branched-chain-amino-acid aminotransferase	ISS			PTHR42743:SF3	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE-LIKE PROTEIN 1-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00006	Apoptosis signaling pathway	P00309	Smac/Diablo	PANTR|Ensembl=ENSPTRG00000005576|UniProtKB=H2Q741	Uncharacterized protein	ISS			PTHR32247:SF3	DIABLO HOMOLOG, MITOCHONDRIAL
P00004	Alzheimer disease-presenilin pathway	P00137	Tip60	PANTR|Ensembl=ENSPTRG00000009383|UniProtKB=H2QDD8	Histone acetyltransferase	ISS			PTHR10615:SF102	HISTONE ACETYLTRANSFERASE KAT7
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00057	Wnt signaling pathway	P01471	alpha-catenin	DROME|FlyBase=FBgn0010215|UniProtKB=P35220	Catenin alpha	IDA	1768802	PubMed	PTHR18914:SF9	CATENIN ALPHA
P00059	p53 pathway	G04692	R2	MONDO|Ensembl=ENSMODG00000014763|UniProtKB=F7GGT3	Uncharacterized protein	ISS			PTHR23409:SF20	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00047	PDGF signaling pathway	P01151	PKB	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00059	p53 pathway	P01486	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01242	Casein kinase I	MACMU|Ensembl=ENSMMUG00000006646|UniProtKB=F7H415	Uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF151	CASEIN KINASE I ISOFORM GAMMA-3
P00047	PDGF signaling pathway	P01161	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	88234494	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04547	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00059	p53 pathway	P04623	CBP	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	IDA	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P02751	Lysine biosynthesis	P03009	Aspartokinase	BACSU|EnsemblGenome=BSU03790|UniProtKB=P94417	Aspartokinase 3	ISS			PTHR21499:SF38	ASPARTOKINASE 1, CHLOROPLASTIC
P00029	Huntington disease	P00807	Actin	MOUSE|MGI=MGI=87904|UniProtKB=P60710	Actin, cytoplasmic 1	IDA	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00046	Oxidative stress response	P01129	JNK1/2	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00005	Angiogenesis	P00189	Fzd	MOUSE|MGI=MGI=1196625|UniProtKB=O70421	Frizzled-1	ISS	8717036	PubMed	PTHR11309:SF81	FRIZZLED-1
P00053	T cell activation	P01324	rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P05913	Enkephalin release	P05976	Enkephalin	PANTR|Ensembl=ENSPTRG00000020270|UniProtKB=H2QW70	Proenkephalin	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00048	PI3 kinase pathway	P01188	Gbetagamma	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00029	Huntington disease	P00775	Rac	ARATH|TAIR=AT1G20090|UniProtKB=Q38919	Rac-like GTP-binding protein ARAC4	TAS			PTHR24072:SF194	RAC-LIKE GTP-BINDING PROTEIN ARAC4-RELATED
P00021	FGF signaling pathway	P00629	PP2A	CANLF|Ensembl=ENSCAFG00000015787|UniProtKB=F6V7D9	Uncharacterized protein	ISS	11007767	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00030	Hypoxia response via HIF activation	P00819	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00007	Axon guidance mediated by semaphorins	P00340	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	20264070	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00021	FGF signaling pathway	P00643	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P06959	CCKR signaling map	P07151	p52 SHC1	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	RCA	10400698	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	RAT|RGD=1310130|UniProtKB=D4A942	Protein Fpr-rs4	ISS			PTHR24225:SF26	FORMYL PEPTIDE RECEPTOR-RELATED SEQUENCE 4
P00012	Cadherin signaling pathway	P00474	Wnt	MACMU|Ensembl=ENSMMUG00000018445|UniProtKB=F7HEW6	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00005	Angiogenesis	P00216	Caspase 9	HUMAN|HGNC=1511|UniProtKB=P55211	Caspase-9	IDA	11440972	PubMed	PTHR10454:SF157	CASPASE-9
P00049	Parkinson disease	P01215	Syntaxin	ARATH|TAIR=AT5G46860|UniProtKB=P93654	Syntaxin-22	IPI			PTHR19957:SF38	T-SNARE DOMAIN-CONTAINING PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00160	Nectin 1alpha	CANLF|Ensembl=ENSCAFG00000012012|UniProtKB=F1PCB6	Uncharacterized protein	ISS	12376527	PubMed	PTHR23277:SF69	NECTIN-1
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MACMU|Ensembl=ENSMMUG00000013084|UniProtKB=F7H390	Uncharacterized protein	ISS			PTHR24247:SF108	5-HYDROXYTRYPTAMINE RECEPTOR 5A
P02775	Salvage pyrimidine ribonucleotides	P03155	Cytosine deaminase	YEAST|SGD=S000006266|UniProtKB=Q12178	Cytosine deaminase	RCA			PTHR45395:SF1	CYTOSINE DEAMINASE
P00010	B cell activation	P00371	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00539	14-3-3	MONDO|Ensembl=ENSMODG00000009856|UniProtKB=F6WA79	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IGI	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00852	PYK2	RAT|RGD=628758|UniProtKB=P70600	Protein-tyrosine kinase 2-beta	ISS	10753828	PubMed	PTHR24418:SF94	PROTEIN-TYROSINE KINASE 2-BETA
P00057	Wnt signaling pathway	P01464	Pygo	BOVIN|Ensembl=ENSBTAG00000004331|UniProtKB=A7E348	PYGO2 protein	ISS	11955446	PubMed	PTHR23194:SF7	PYGOPUS HOMOLOG 2
P00046	Oxidative stress response	P01129	JNK1/2	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04398	p53 pathway feedback loops 2	P04668	p53	RAT|RGD=620863|UniProtKB=Q9JJP6	Tumor protein 63	TAS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	PANTR|Ensembl=ENSPTRG00000016100|UniProtKB=H2QPJ5	Uncharacterized protein	ISS	1333052	PubMed	PTHR24241:SF22	GONADOTROPIN-RELEASING HORMONE RECEPTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CANLF|Gene=GNRHR|UniProtKB=Q9MZI6	Gonadotropin-releasing hormone receptor	ISS	12629106	PubMed	PTHR24241:SF22	GONADOTROPIN-RELEASING HORMONE RECEPTOR
P00048	PI3 kinase pathway	P01177	P110ACT	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00006	Apoptosis signaling pathway	P00260	AKT	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	ISS	12655147	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00005	Angiogenesis	P00233	CSL	CHICK|Ensembl=ENSGALG00000014365|UniProtKB=F1NIJ8	Uncharacterized protein	ISS	9043084	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00005	Angiogenesis	P00206	Wnt	HUMAN|HGNC=13829|UniProtKB=Q9GZT5	Protein Wnt-10a	ISS	8717036	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	7925653	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00260	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01292	RSmads	RAT|RGD=3031|UniProtKB=O70436	Mothers against decapentaplegic homolog 2	TAS	9395284	PubMed	PTHR13703:SF42	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 2
P00018	EGF receptor signaling pathway	P00559	MEK1-2	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IGI	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CAEBR|Gene=CBG17587|UniProtKB=A8XRA5	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01236	Casein kinase II	TAKRU|Ensembl=ENSTRUG00000000811|UniProtKB=H2RP90	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00006	Apoptosis signaling pathway	P00260	AKT	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01167	Ets	RAT|RGD=2583|UniProtKB=P41156	Protein C-ets-1	ISS	15579511	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00018	EGF receptor signaling pathway	P00552	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P02776	Serine glycine biosynthesis	P03160	Phosphoglycerate dehydrogenase	RAT|RGD=61987|UniProtKB=O08651	D-3-phosphoglycerate dehydrogenase	ISS			PTHR42938:SF5	D-3-PHOSPHOGLYCERATE DEHYDROGENASE
P04393	Ras Pathway	P04541	p90RSK	BOVIN|Ensembl=ENSBTAG00000014447|UniProtKB=A4IFF4	Ribosomal protein S6 kinase	ISS	7688567	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00807	Actin	CHICK|Ensembl=ENSGALG00000009844|UniProtKB=P68034	Actin, alpha cardiac muscle 1	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00049	Parkinson disease	P01211	ERK	ORYSJ|EnsemblGenome=OS06G0699400|UniProtKB=Q5Z859	Mitogen-activated protein kinase 4	IDA	6491800	gi	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00029	Huntington disease	P00807	Actin	TRIAD|EnsemblGenome=TriadG56111|UniProtKB=B3RX77	Non-muscle actin 6.2	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00006	Apoptosis signaling pathway	P00312	MKK7	PANTR|Ensembl=ENSPTRG00000010409|UniProtKB=H2RBC8	Uncharacterized protein	ISS			PTHR24361:SF387	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	TAS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000001583|UniProtKB=F7BBM1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00029	Huntington disease	P00767	Pro-caspase 8	CHICK|Ensembl=ENSGALG00000008355|UniProtKB=F1NXP6	Uncharacterized protein	IDA	11788820	PubMed	PTHR10454:SF162	CASPASE-8
P00021	FGF signaling pathway	P00632	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	CANLF|Ensembl=ENSCAFG00000002046|UniProtKB=E2RBE7	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	P01458	Protein Kinase C	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00049	Parkinson disease	P01238	14-3-3	YEAST|SGD=S000000979|UniProtKB=P29311	Protein BMH1	IDA	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P05730	Endogenous cannabinoid signaling	P05748	mGluR	RAT|RGD=2746|UniProtKB=P31424	Metabotropic glutamate receptor 5	ISS	9407094	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000007445|UniProtKB=F6SWI4	Uncharacterized protein	ISS	20088160	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000040439|UniProtKB=F6Q2H9	Uncharacterized protein	ISS	12441358	PubMed	PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01182	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P05918	p38 MAPK pathway	P06020	p38delta	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	ECOLI|EcoGene=EG10036|UniProtKB=P23883	Aldehyde dehydrogenase PuuC	IC			PTHR11699:SF211	ALDEHYDE DEHYDROGENASE 5, MITOCHONDRIAL
P00029	Huntington disease	P00780	Microtubule	CHICK|Ensembl=ENSGALG00000008586|UniProtKB=F1NYB1	Uncharacterized protein	IDA	9454836	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00010	B cell activation	P00375	Calmodulin	ORYSJ|EnsemblGenome=OS01G0267900|UniProtKB=Q0JNS6	Calmodulin-1	ISS	9753452	PubMed	PTHR23050:SF245	AT16150P-RELATED
P05917	Opioid proopiomelanocortin pathway	P06004	Mu or Delta receptor	MACMU|Ensembl=ENSMMUG00000009389|UniProtKB=F7HEV7	Uncharacterized protein	ISS	11259498	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	HUMAN|HGNC=16852|UniProtKB=O75159	Suppressor of cytokine signaling 5	ISS	15032587	PubMed	PTHR44282:SF3	SUPPRESSOR OF CYTOKINE SIGNALING 5
P00057	Wnt signaling pathway	P01443	Phospholipase C	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00019	Endothelin signaling pathway	P00567	PKG	MONDO|Ensembl=ENSMODG00000020783|UniProtKB=F6YKH9	cGMP-dependent protein kinase	ISS	12775716	PubMed	PTHR24353:SF24	SUBFAMILY NOT NAMED
P00060	Ubiquitin proteasome pathway	P01491	E2	SCHPO|PomBase=SPCC338.05c|UniProtKB=O74983	Ubiquitin-conjugating enzyme spm2	ISS			PTHR43915:SF5	LD28904P
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00037	Ionotropic glutamate receptor pathway	P01018	Glu1	MOUSE|MGI=MGI=95808|UniProtKB=P23818	Glutamate receptor 1	ISS	12871085	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00010	B cell activation	P00379	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00053	T cell activation	P01312	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00011	Blood coagulation	P00427	alpha2-macroglobulin	MOUSE|MGI=MGI=2449119|UniProtKB=Q6GQT1	Alpha-2-macroglobulin-P	ISS	6978425	gi	PTHR11412:SF135	ALPHA-2-MACROGLOBULIN
P00006	Apoptosis signaling pathway	P00307	ELF2alpha	MACMU|Ensembl=ENSMMUG00000021419|UniProtKB=F7EFD7	Eukaryotic translation initiation factor 2 subunit 1	ISS			PTHR10602:SF0	EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	MOUSE|MGI=MGI=109284|UniProtKB=Q61144	Presenilin-2	TAS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00006	Apoptosis signaling pathway	P00310	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00922	Collagen	MOUSE|MGI=MGI=88450|UniProtKB=Q07563	Collagen alpha-1(XVII) chain	IDA	10778855	PubMed	PTHR44606:SF1	COLLAGEN ALPHA-1 XVII  CHAIN
P05918	p38 MAPK pathway	P06020	p38delta	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	RCA	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176910	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	STRPU|Gene=CYIIIB|UniProtKB=P18499	Actin, cytoskeletal 3B	IDA	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	TRIAD|EnsemblGenome=TriadG18503|UniProtKB=B3RID1	Putative uncharacterized protein	ISS			PTHR23431:SF3	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5
P00006	Apoptosis signaling pathway	P00274	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=107435|UniProtKB=P97326	Cadherin-6	IDA	8120095	PubMed	PTHR24027:SF322	CADHERIN-6
P00008	Axon guidance mediated by Slit/Robo	P00347	Abl	HUMAN|HGNC=76|UniProtKB=P00519	Tyrosine-protein kinase ABL1	ISS			PTHR24418:SF88	TYROSINE-PROTEIN KINASE ABL1
P00034	Integrin signalling pathway	P00943	Talin	RAT|RGD=1306247|UniProtKB=G3V852	Protein Tln1	ISS	14702644	PubMed	PTHR19981:SF7	MESODERM DEVELOPMENT CANDIDATE 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ASHGO|EnsemblGenome=AGOS_ABR222W|UniProtKB=Q75D00	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00052	TGF-beta signaling pathway	P01286	TGFbeta	DANRE|ZFIN=ZDB-GENE-011214-1|UniProtKB=F1R5Z7	Serine palmitoyltransferase small subunit B	TAS	11748836	PubMed	PTHR11848:SF152	SERINE PALMITOYLTRANSFERASE SMALL SUBUNIT B
P02746	Heme biosynthesis	P02983	Hydroxymethylbilane synthase	YEAST|SGD=S000002364|UniProtKB=P28789	Porphobilinogen deaminase	ISS			PTHR11557:SF0	PORPHOBILINOGEN DEAMINASE
P00029	Huntington disease	P00811	Arp2/3 complex	PANTR|Ensembl=ENSPTRG00000001767|UniProtKB=G2HG81	Actin-related protein 2/3 complex subunit 5	ISS	12932731	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	CHICK|Ensembl=ENSGALG00000009640|UniProtKB=F1P0I0	Muscarinic acetylcholine receptor	TAS	12181435	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00029	Huntington disease	P00772	FIP-2	BOVIN|Ensembl=ENSBTAG00000014551|UniProtKB=A4IF78	Tumor necrosis factor alpha-induced protein 8	ISS			PTHR12757:SF3	TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 8
P02757	O-antigen biosynthesis	P03052	N-acetylglucosamine-1-phosphate uridyltransferase	THEMA|EnsemblGenome=TM_1629|UniProtKB=Q9X1W4	Bifunctional protein GlmU	ISS			PTHR43584:SF3	BIFUNCTIONAL PROTEIN GLMU
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MONDO|Ensembl=ENSMODG00000001873|UniProtKB=F6YFT5	Uncharacterized protein	ISS			PTHR13140:SF273	UNCONVENTIONAL MYOSIN-VA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00047	PDGF signaling pathway	P01160	IP3 receptor	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04393	Ras Pathway	P04542	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05731	GABA-B receptor II signaling	P05760	AC	MOUSE|MGI=MGI=99673|UniProtKB=P84309	Adenylate cyclase type 5	ISS	94139935	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04543	MEKK1/4	CANLF|Ensembl=ENSCAFG00000000760|UniProtKB=E2R9L4	Uncharacterized protein	ISS	12878610	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00005	Angiogenesis	P00256	PLC-gamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00047	PDGF signaling pathway	P01172	c-Myc	MACMU|Ensembl=ENSMMUG00000014601|UniProtKB=B8XIA5	Myc proto-oncogene protein	ISS	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00047	PDGF signaling pathway	P01153	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IDA	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00035	Interferon-gamma signaling pathway	P00958	PIAS	MOUSE|MGI=MGI=1913125|UniProtKB=O88907	E3 SUMO-protein ligase PIAS1	TAS	8682149	PubMed	PTHR10782:SF11	E3 SUMO-PROTEIN LIGASE PIAS1
P00018	EGF receptor signaling pathway	P00556	PLCgamma	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00049	Parkinson disease	P01236	Casein kinase II	PHYPA|Gene=PHYPADRAFT_145621|UniProtKB=A9THD0	Predicted protein	ISS	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00011	Blood coagulation	P00410	GP IIb	PANTR|Ensembl=ENSPTRG00000009277|UniProtKB=H2QD72	Uncharacterized protein	ISS	3487386	PubMed	PTHR23220:SF73	INTEGRIN ALPHA-IIB
P00021	FGF signaling pathway	P00648	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	15572354	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	RCA	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00034	Integrin signalling pathway	P00932	FAK	CAEEL|WormBase=WBGene00002213|UniProtKB=Q95YD4	Inactive tyrosine-protein kinase kin-32	IPI			PTHR24418:SF367	FOCAL ADHESION KINASE, ISOFORM D
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=628675|UniProtKB=Q9Z2A6	Mitogen-activated protein kinase 15	IDA	10514528	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	HUMAN|HGNC=1950|UniProtKB=P11229	Muscarinic acetylcholine receptor M1	IDA	11166329	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=628675|UniProtKB=Q9Z2A6	Mitogen-activated protein kinase 15	TAS	12787066	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00052	TGF-beta signaling pathway	P01275	P38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04398	p53 pathway feedback loops 2	P04665	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00060	Ubiquitin proteasome pathway	P01494	19S proteasome	YEAST|SGD=S000002802|UniProtKB=P33298	26S protease regulatory subunit 6B homolog	ISS			PTHR23073:SF8	26S PROTEASE REGULATORY SUBUNIT 6B
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00388	PLC gamma2	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00018	EGF receptor signaling pathway	P00562	p38	CAEBR|Gene=CBG01555|UniProtKB=A8WRD7	Mitogen-activated protein kinase	ISS	11703092	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P06664	Gonadotropin-releasing hormone receptor pathway	G06905	CNP	MOUSE|MGI=MGI=97369|UniProtKB=Q61839	C-type natriuretic peptide	RCA			PTHR12167:SF2	C-TYPE NATRIURETIC PEPTIDE
P00036	Interleukin signaling pathway	P00994	FKHRL1	RAT|RGD=1309196|UniProtKB=D3ZBQ1	Forkhead box O3a (Predicted)	ISS	14775847	gi	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00034	Integrin signalling pathway	P00931	Integrin beta	MOUSE|MGI=MGI=96614|UniProtKB=O70309	Integrin beta-5	IDA	3487386	PubMed	PTHR10082:SF26	INTEGRIN BETA-5
P00009	Axon guidance mediated by netrin	P00363	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02776	Serine glycine biosynthesis	P03157	Phosphoserine aminotransferase	ARATH|TAIR=AT4G35630|UniProtKB=Q96255	Phosphoserine aminotransferase 1, chloroplastic	ISS	15237069	gi	PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P00011	Blood coagulation	P00431	tPA	MOUSE|MGI=MGI=97610|UniProtKB=P11214	Tissue-type plasminogen activator	ISS	137121	gi	PTHR44617:SF1	TISSUE-TYPE PLASMINOGEN ACTIVATOR
P00053	T cell activation	P01311	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04567	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00973	PKB	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04574	PLD	BOVIN|Gene=PLD2|UniProtKB=Q0V8L6	Phospholipase D2	ISS	9538008	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04393	Ras Pathway	P04572	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IDA	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00036	Interleukin signaling pathway	P00965	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00021	FGF signaling pathway	P00638	PLCgamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MOUSE|MGI=MGI=2660854|UniProtKB=Q8C0T9	Adenylate cyclase type 10	ISS	9874775	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	ANOGA|EnsemblGenome=AGAP001065|UniProtKB=F5HM13	Serine hydroxymethyltransferase	ISS			PTHR11680:SF21	SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	RAT|RGD=2734|UniProtKB=Q01812	Glutamate receptor ionotropic, kainate 4	ISS	12778120	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PLAF7|EnsemblGenome=PF10_0084|UniProtKB=Q7KQL5	Tubulin beta chain	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00045	Notch signaling pathway	P01102	Sel 10	MACMU|Ensembl=ENSMMUG00000020330|UniProtKB=F6WGU1	F-box/WD repeat-containing protein 7 isoform 1	ISS			PTHR44007:SF6	F-BOX/WD REPEAT-CONTAINING PROTEIN 7
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00047	PDGF signaling pathway	P01149	MNK1/2	BOVIN|Gene=MKNK1|UniProtKB=Q58D94	MAP kinase-interacting serine/threonine-protein kinase 1	ISS	9155017	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00011	Blood coagulation	P00406	Fibrinogen	CHICK|Gene=FGB|UniProtKB=Q02020	Fibrinogen beta chain (Fragment)	ISS			PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	PANTR|Gene=CHRM3|UniProtKB=Q9N2A4	Muscarinic acetylcholine receptor M3	IDA	10069496	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00004	Alzheimer disease-presenilin pathway	P00141	Membrane metalloprotease	MOUSE|MGI=MGI=2443938|UniProtKB=Q3U435	Matrix metalloproteinase-25	RCA			PTHR10201:SF142	MATRIX METALLOPROTEINASE-25
P00006	Apoptosis signaling pathway	P00297	NFkappaB	MACMU|Ensembl=ENSMMUG00000002990|UniProtKB=F7GVV0	Uncharacterized protein	ISS	20151924	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00053	T cell activation	P01300	ERK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00736	CalDAG-GEF	MOUSE|MGI=MGI=1314635|UniProtKB=Q9Z1S3	RAS guanyl-releasing protein 1	IDA	10835426	PubMed	PTHR23113:SF174	RAS GUANYL-RELEASING PROTEIN 1
P00018	EGF receptor signaling pathway	P00561	STAT	MOUSE|MGI=MGI=103038|UniProtKB=P42227	Signal transducer and activator of transcription 3	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01154	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P02721	ATP synthesis	P02794	F1 beta	TAKRU|Ensembl=ENSTRUG00000011422|UniProtKB=H2TVZ0	ATP synthase subunit beta	ISS	2896550	PubMed	PTHR15184:SF44	ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL
P00053	T cell activation	P01307	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00034	Integrin signalling pathway	P00936	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00805	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00551	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06819	SMAD2-4	MOUSE|MGI=MGI=109452|UniProtKB=P70340	Mothers against decapentaplegic homolog 1	RCA	12736218	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CAEBR|Gene=CBG05858|UniProtKB=A8X1H0	Protein CBR-EGL-19 (Fragment)	ISS	9199552	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	P01457	GBeta	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P02740	De novo pyrimidine ribonucleotides biosythesis	P02927	Dihydrooratate oxidase	CAEEL|WormBase=WBGene00020932|UniProtKB=O01815	Dihydroorotate dehydrogenase (quinone), mitochondrial	ISS			PTHR43517:SF1	DIHYDROOROTATE DEHYDROGENASE  QUINONE , MITOCHONDRIAL
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00049	Parkinson disease	P01236	Casein kinase II	DAPPU|EnsemblGenome=DAPPUDRAFT_223674|UniProtKB=E9GCV0	Putative uncharacterized protein	ISS	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000008826|UniProtKB=F6XUU0	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	MOUSE|MGI=MGI=1346037|UniProtKB=Q9WTL4	Insulin receptor-related protein	ISS	11182407	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00627	ERK1-2	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	9298898	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01451	Galpha	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00010	B cell activation	P00370	NFkappaB	HUMAN|HGNC=7795|UniProtKB=Q00653	Nuclear factor NF-kappa-B p100 subunit	IDA	12574369	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MOUSE|MGI=MGI=2444552|UniProtKB=Q8BFZ3	Beta-actin-like protein 2	IC	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P02747	Histidine biosynthesis	P02991	Histidinephosphate aminotransferase	MYCTU|EnsemblGenome=Rv3772|UniProtKB=P9WML5	Putative phenylalanine aminotransferase	ISS			PTHR43643:SF3	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00807	Actin	DROME|FlyBase=FBgn0000042|UniProtKB=P10987	Actin-5C	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IPI	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ORYSJ|EnsemblGenome=OS05G0438800|UniProtKB=Q75HX0	Actin	IC	14684598	PubMed	PTHR11937:SF248	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00049	Parkinson disease	P01234	GRK	HUMAN|HGNC=290|UniProtKB=P35626	Beta-adrenergic receptor kinase 2	IDA	10852916	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01080	AChE	BOVIN|Ensembl=ENSBTAG00000011139|UniProtKB=P32749	Cholinesterase	ISS	86008285	PubMed	PTHR43918:SF5	CHOLINESTERASE
P00048	PI3 kinase pathway	P01202	p85	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00021	FGF signaling pathway	P00630	RKIP	DROME|FlyBase=FBgn0011294|UniProtKB=P54185	Putative odorant-binding protein A5	ISS	94121915	PubMed	PTHR11362:SF28	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P00059	p53 pathway	P04623	CBP	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00221	JNK1	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	BOVIN|Ensembl=ENSBTAG00000006305|UniProtKB=P00570	Adenylate kinase isoenzyme 1	ISS			PTHR23359:SF59	ADENYLATE KINASE ISOENZYME 1
P00034	Integrin signalling pathway	P00944	Actin	ORNAN|Ensembl=ENSOANG00000007716|UniProtKB=F6UDX9	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	RAT|RGD=1307994|UniProtKB=B6RK61	Myosin heavy chain 7B	ISS	10938134	PubMed	PTHR13140:SF358	MYOSIN-7B
P00025	Hedgehog signaling pathway	P00692	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00049	Parkinson disease	P01211	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00629	PP2A	MONDO|Ensembl=ENSMODG00000014177|UniProtKB=F6U7A6	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=71034|UniProtKB=P32305	5-hydroxytryptamine receptor 7	IDA			PTHR24247:SF116	5-HYDROXYTRYPTAMINE RECEPTOR 7
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00010	B cell activation	P00381	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00023	General transcription regulation	P00664	TFIIH complex	SCHPO|PomBase=SPBC13G1.13|UniProtKB=P87303	RNA polymerase II transcription factor B subunit 2	ISS			PTHR13152:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00021	FGF signaling pathway	P00623	FGF	MACMU|Ensembl=ENSMMUG00000019185|UniProtKB=F6QZ62	Fibroblast growth factor	ISS	11032730	PubMed	PTHR11486:SF72	FIBROBLAST GROWTH FACTOR 20
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00810	GAPDH	PHANO|Gene=SNOG_01278|UniProtKB=Q9P8C0	Glyceraldehyde-3-phosphate dehydrogenase	IPI			PTHR10836:SF52	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	8925912	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00057	Wnt signaling pathway	P01443	Phospholipase C	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00019	Endothelin signaling pathway	P00570	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	ISS	91072385	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	PANTR|Ensembl=ENSPTRG00000015131|UniProtKB=H2QMZ1	Uncharacterized protein	ISS			PTHR22778:SF26	DIHYDROFOLATE REDUCTASE, MITOCHONDRIAL
P00034	Integrin signalling pathway	P00927	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12912997	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	DANRE|ZFIN=ZDB-GENE-990415-45|UniProtKB=P50392	Cytosolic phospholipase A2	ISS	94299545	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00037	Ionotropic glutamate receptor pathway	P01001	KA4	MOUSE|MGI=MGI=95817|UniProtKB=Q8BMF5	Glutamate receptor ionotropic, kainate 4	ISS	12778120	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1170702	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06812	L-type Ca2+	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	RCA	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IDA	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00237	FRP	MOUSE|MGI=MGI=108476|UniProtKB=Q61086	Frizzled-3	ISS	11212302	PubMed	PTHR11309:SF22	FRIZZLED-3
P06959	CCKR signaling map	P07197	Gbeta/gamma	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	RCA	12853286	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	CANLF|Gene=GRIN1|UniProtKB=Q5R1P0	Glutamate receptor ionotropic, NMDA 1	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	RCA	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2522|UniProtKB=P30729	D(4) dopamine receptor	IDA	11248120	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	IDA	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MACMU|Ensembl=ENSMMUG00000017374|UniProtKB=F7H6T7	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00029	Huntington disease	P00780	Microtubule	SCLS1|EnsemblGenome=SS1G_04652|UniProtKB=A7EH60	Beta tubulin	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00729	Goalpha	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00560	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P06587	Nicotine pharmacodynamics pathway	P06605	KCNK3/9	PANTR|Ensembl=ENSPTRG00000020614|UniProtKB=H2QWR7	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00006	Apoptosis signaling pathway	P00273	p53	BOVIN|Ensembl=ENSBTAG00000001069|UniProtKB=P67939	Cellular tumor antigen p53	ISS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00048	PI3 kinase pathway	P01185	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04393	Ras Pathway	P04570	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01443	Phospholipase C	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ORNAN|Ensembl=ENSOANG00000000460|UniProtKB=F7F4W9	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P05731	GABA-B receptor II signaling	P05755	Gbeta	RAT|RGD=69319|UniProtKB=P54313	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00036	Interleukin signaling pathway	P00996	STAT	BOVIN|Gene=STAT5B|UniProtKB=Q9TUM3	Signal transducer and activator of transcription 5B	IC	96210005	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	PANTR|Ensembl=ENSPTRG00000013189|UniProtKB=H2QJV1	Uncharacterized protein	ISS	192340	OMIM	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00049	Parkinson disease	P01227	20S proteasome	LEIMA|EnsemblGenome=LmjF.21.1830|UniProtKB=Q4QC00	Proteasome subunit alpha type	TAS	12859888	PubMed	PTHR11599:SF14	PROTEASOME SUBUNIT ALPHA TYPE-5
P02788	Xanthine and guanine salvage pathway	P03245	Guanine phosphoribosyl transferase	BACSU|EnsemblGenome=BSU00680|UniProtKB=P37472	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P02750	Lipoate_biosynthesis	P03004	Lipoate synthase	MOUSE|MGI=MGI=1934604|UniProtKB=Q99M04	Lipoyl synthase, mitochondrial	ISS			PTHR10949:SF0	LIPOYL SYNTHASE, MITOCHONDRIAL
P00012	Cadherin signaling pathway	P00474	Wnt	CANLF|Ensembl=ENSCAFG00000032632|UniProtKB=J9P2Q5	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P02766	Phenylethylamine degradation	P03103	Phenylethylamine oxidase	MOUSE|MGI=MGI=2682321|UniProtKB=Q6WIZ7	Amine oxidase	ISS			PTHR10638:SF25	AMINE OXIDASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	G01535	PIG3	ARATH|TAIR=AT4G21580|UniProtKB=O65423	AT4g21580/F18E5_200	TAS			PTHR43006:SF7	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00193	SOS-1	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	CANLF|Ensembl=ENSCAFG00000002292|UniProtKB=E2RPI9	Uncharacterized protein	ISS	9388255	PubMed	PTHR10639:SF1	CLATHRIN LIGHT CHAIN A
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00005	Angiogenesis	P00236	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00274	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00029	Huntington disease	P00807	Actin	HUMAN|HGNC=143|UniProtKB=P68032	Actin, alpha cardiac muscle 1	IDA	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	9332390	PubMed	PTHR10202:SF13	PRESENILIN-2
P00005	Angiogenesis	P00219	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00017	DNA replication	P00530	Top	RAT|RGD=621246|UniProtKB=Q9WUL0	DNA topoisomerase 1	RCA			PTHR10290:SF5	DNA TOPOISOMERASE 1
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	HUMAN|HGNC=7884|UniProtKB=Q99466	Neurogenic locus notch homolog protein 4	IDA	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PHYPA|Gene=PHYPADRAFT_226658|UniProtKB=A9TYG3	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=99879|UniProtKB=Q62101	Serine/threonine-protein kinase D1	IGI	8078925	PubMed	PTHR22968:SF9	SERINE/THREONINE-PROTEIN KINASE D1
P00057	Wnt signaling pathway	P01448	CBP	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000017549|UniProtKB=H2QS18	Dopamine receptor D1	ISS			PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00034	Integrin signalling pathway	P00922	Collagen	PANTR|Ensembl=ENSPTRG00000018329|UniProtKB=H2R356	Uncharacterized protein	ISS	10778855	PubMed	PTHR44652:SF3	COLLAGEN ALPHA-1 IX  CHAIN
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05915	Opioid proenkephalin pathway	P05994	G-protein	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00053	T cell activation	P01307	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000043971|UniProtKB=E1BPT8	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P04398	p53 pathway feedback loops 2	P04651	Ras	MONDO|Gene=KRAS|UniProtKB=Q07983	GTPase KRas	ISS	9869449	PubMed	PTHR24070:SF186	GTPASE KRAS
P05915	Opioid proenkephalin pathway	P05994	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00029	Huntington disease	P00807	Actin	DANRE|ZFIN=ZDB-GENE-030131-1229|UniProtKB=Q6DHS1	Actin, alpha 2, smooth muscle, aorta	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00029	Huntington disease	P00805	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P06002	G-protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00570	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00010	B cell activation	P00402	Jnk	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01208	Hsp70	NEUCR|EnsemblGenome=EFNCRG00000009411|UniProtKB=Q01233	Heat shock 70 kDa protein	IDA	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00047	PDGF signaling pathway	P01151	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IDA	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00029	Huntington disease	P00796	Kainate receptor	BOVIN|Ensembl=ENSBTAG00000009269|UniProtKB=F1MCM2	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	ARATH|TAIR=AT5G58700|UniProtKB=Q944C1	Phosphoinositide phospholipase C 4	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P02740	De novo pyrimidine ribonucleotides biosythesis	P02928	Dihydroorotase	SULSO|EnsemblGenome=SSO0611|UniProtKB=Q9UX05	Dihydroorotase	ISS			PTHR43668:SF2	ALLANTOINASE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	ISS	http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	CIOIN|Ensembl=ENSCING00000003902|UniProtKB=Q967X2	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	BOVIN|Ensembl=ENSBTAG00000043971|UniProtKB=E1BPT8	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	RAT|RGD=2395|UniProtKB=P07756	Carbamoyl-phosphate synthase [ammonia], mitochondrial	ISS			PTHR11405:SF38	CARBAMOYL-PHOSPHATE SYNTHASE  AMMONIA , MITOCHONDRIAL
P00056	VEGF signaling pathway	P01411	Ras	DAPPU|EnsemblGenome=DAPPUDRAFT_301818|UniProtKB=E9I1I7	Putative uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	BACSU|EnsemblGenome=BSU01370|UniProtKB=P16304	Adenylate kinase	ISS			PTHR23359:SF22	GTP:AMP PHOSPHOTRANSFERASE, MITOCHONDRIAL
P00012	Cadherin signaling pathway	P00475	Frizzled	MONDO|Ensembl=ENSMODG00000016310|UniProtKB=F7A659	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF31	FRIZZLED-7
P00005	Angiogenesis	P00203	Erk	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00030	Hypoxia response via HIF activation	P00819	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	TAS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00996	STAT	BOVIN|Gene=STAT5B|UniProtKB=Q9TUM3	Signal transducer and activator of transcription 5B	IC	22320921	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P05918	p38 MAPK pathway	P06038	TRAF6	RAT|RGD=1306853|UniProtKB=B5DF45	TNF receptor-associated factor 6	ISS			PTHR10131:SF111	TNF RECEPTOR-ASSOCIATED FACTOR 6
P05913	Enkephalin release	P05972	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CHICK|Ensembl=ENSGALG00000017178|UniProtKB=F1N982	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	DANRE|ZFIN=ZDB-GENE-030131-9966|UniProtKB=Q6TH03	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01026	KA	CHICK|Ensembl=ENSGALG00000001172|UniProtKB=P19439	Probable glutamate receptor	ISS	12871085	PubMed	PTHR18966:SF282	GLUTAMATE RECEPTOR-RELATED
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CIOIN|Ensembl=ENSCING00000001377|UniProtKB=F6SDC9	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	DICDI|dictyBase=DDB_G0292736|UniProtKB=Q02158	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS			PTHR10336:SF105	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	CANLF|Ensembl=ENSCAFG00000013324|UniProtKB=F1PCS0	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	MACMU|Ensembl=ENSMMUG00000009054|UniProtKB=F7F735	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	BOVIN|Ensembl=ENSBTAG00000001060|UniProtKB=P25930	C-X-C chemokine receptor type 4	ISS	11943720	PubMed	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P00053	T cell activation	P01311	Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	IDA	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00057	Wnt signaling pathway	P01444	Wnt	CANLF|Ensembl=ENSCAFG00000014987|UniProtKB=E2RH98	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05731	GABA-B receptor II signaling	P05760	AC	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IDA	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	RAT|RGD=1309318|UniProtKB=D4A3N4	Adenylate cyclase 1 (Predicted)	ISS	89298382	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P00022	General transcription by RNA polymerase I	P00657	TBP	CAEBR|Gene=CBG09138|UniProtKB=A8X861	Protein CBR-TBP-1	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	DROME|FlyBase=FBgn0020386|UniProtKB=Q9W0V1	3-phosphoinositide-dependent protein kinase 1	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	HUMAN|HGNC=6695|UniProtKB=O75074	Low-density lipoprotein receptor-related protein 3	IDA	11907044	PubMed	PTHR44062:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00047	PDGF signaling pathway	P01164	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PLAF7|EnsemblGenome=PF11_0147|UniProtKB=Q7KQK7	Mitogen-activated protein kinase	IDA	10514528	PubMed	PTHR24055:SF189	SUBFAMILY NOT NAMED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04393	Ras Pathway	P04565	MKK4/7	MACMU|Ensembl=ENSMMUG00000019842|UniProtKB=F7FU91	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00642	MEK1-2	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05915	Opioid proenkephalin pathway	P05994	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS			PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00010	B cell activation	P00371	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=11331|UniProtKB=P30874	Somatostatin receptor type 2	IDA	12562507	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00034	Integrin signalling pathway	P00916	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P05915	Opioid proenkephalin pathway	P05994	G-protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00022	General transcription by RNA polymerase I	P00649	TAF-IC	MOUSE|MGI=MGI=109576|UniProtKB=Q6PDZ2	TATA box-binding protein-associated factor RNA polymerase I subunit C	ISS	604905	OMIM	PTHR15319:SF1	TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT C
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IDA	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	CHICK|Ensembl=ENSGALG00000013781|UniProtKB=F1P1D5	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF344	MYOSIN-7
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	10395542	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00037	Ionotropic glutamate receptor pathway	P01005	NR2D	RAT|RGD=2740|UniProtKB=Q62645	Glutamate receptor ionotropic, NMDA 2D	ISS	11554549	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00021	FGF signaling pathway	P00628	JNK1-3	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00034	Integrin signalling pathway	P00923	Arf1	DICPU|Gene=DICPUDRAFT_93077|UniProtKB=F1A1N6	ADP-ribosylation factor 1	ISS	12932731	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P06664	Gonadotropin-releasing hormone receptor pathway	G06900	3' FSHbeta	MOUSE|MGI=MGI=95582|UniProtKB=Q60687	Follitropin subunit beta	RCA			PTHR11515:SF17	FOLLITROPIN SUBUNIT BETA
P00036	Interleukin signaling pathway	P00980	IRS1/2	MACMU|Ensembl=ENSMMUG00000021790|UniProtKB=F7DE94	Uncharacterized protein	ISS	5031805	gi	PTHR10614:SF7	INSULIN RECEPTOR SUBSTRATE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	BOVIN|Ensembl=ENSBTAG00000016138|UniProtKB=P01217	Glycoprotein hormones alpha chain	ISS	89325834	PubMed	PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000024992|UniProtKB=F6TUR3	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	RAT|RGD=1562253|UniProtKB=D4A3K6	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P00053	T cell activation	P01311	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IDA	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00796	Kainate receptor	BOVIN|Ensembl=ENSBTAG00000034854|UniProtKB=F1N246	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P02723	Adenine and hypoxanthine salvage pathway	P02811	Adenosine deaminase	PANTR|Ensembl=ENSPTRG00000013524|UniProtKB=H2QKE6	Adenosine deaminase	ISS			PTHR11409:SF43	ADENOSINE DEAMINASE
P05731	GABA-B receptor II signaling	P05753	Ca channel	MOUSE|MGI=MGI=88296|UniProtKB=O55017	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	14624853	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00030	Hypoxia response via HIF activation	P00819	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PHANO|EnsemblGenome=SNOG_01139|UniProtKB=H2KNE6	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00059	p53 pathway	G01575	GADD45	MACMU|Ensembl=ENSMMUG00000014808|UniProtKB=F6W540	Growth arrest and DNA damage-inducible protein GADD45 alpha isoform 1	ISS	10097101	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P00010	B cell activation	P00401	jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	11840290	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00029	Huntington disease	P00780	Microtubule	NEMVE|Gene=v1g118944|UniProtKB=A7SHY4	Predicted protein (Fragment)	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04398	p53 pathway feedback loops 2	P04665	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	MYCTU|EnsemblGenome=Rv3315c|UniProtKB=P9WPH3	Cytidine deaminase	ISS			PTHR11644:SF2	CYTIDINE DEAMINASE
P00010	B cell activation	P00379	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00012	Cadherin signaling pathway	P00474	Wnt	MACMU|Ensembl=ENSMMUG00000006621|UniProtKB=F7HKD3	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=88399|UniProtKB=P32211	Muscarinic acetylcholine receptor M4	IDA	8100450	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	IC	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00021	FGF signaling pathway	P00644	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00053	T cell activation	P01326	CD3 delta	HUMAN|HGNC=1673|UniProtKB=P04234	T-cell surface glycoprotein CD3 delta chain	IPI	9348303	PubMed	PTHR10570:SF5	T-CELL SURFACE GLYCOPROTEIN CD3 DELTA CHAIN
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Ensembl=ENSPTRG00000004233|UniProtKB=H2Q4N9	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00052	TGF-beta signaling pathway	P01275	P38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	TAS	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	BOVIN|Ensembl=ENSBTAG00000013369|UniProtKB=E1BA17	Uncharacterized protein	ISS	10778855	PubMed	PTHR44557:SF1	COLLAGEN ALPHA-1 XIV  CHAIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	DANRE|ZFIN=ZDB-GENE-010125-1|UniProtKB=B8JHS2	Uncharacterized protein	IDA	11259487	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00029	Huntington disease	P00790	beta-Tubulin	MACMU|Ensembl=ENSMMUG00000012546|UniProtKB=F7E840	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00011	Blood coagulation	P00429	PN2	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	ISS	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MOUSE|MGI=MGI=1196625|UniProtKB=O70421	Frizzled-1	TAS	8717036	PubMed	PTHR11309:SF81	FRIZZLED-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MOUSE|MGI=MGI=1270849|UniProtKB=Q8BSK8	Ribosomal protein S6 kinase beta-1	ISS	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00025	Hedgehog signaling pathway	P00682	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CHICK|Ensembl=ENSGALG00000015434|UniProtKB=F1NU20	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00053	T cell activation	P01300	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04572	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00056	VEGF signaling pathway	P01407	Erk	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00203	Erk	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	10644715	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00053	T cell activation	P01306	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00019	Endothelin signaling pathway	P00576	Pre-pro ET1-4	PANTR|Ensembl=ENSPTRG00000017730|UniProtKB=H2QSB1	Uncharacterized protein	ISS	15117818	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04398	p53 pathway feedback loops 2	P04651	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	P01457	GBeta	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MACMU|Ensembl=ENSMMUG00000000042|UniProtKB=F7HPH2	Serine/threonine-protein kinase receptor	ISS	11252892	PubMed	PTHR23255:SF64	ACTIVIN RECEPTOR TYPE-2A
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00036	Interleukin signaling pathway	P00976	GSK3	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05923	beta-ARR2	PANTR|Ensembl=ENSPTRG00000008601|UniProtKB=H2QBY1	Arrestin, beta 2	ISS	9388255	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00018	EGF receptor signaling pathway	P00564	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00034	Integrin signalling pathway	P00922	Collagen	MOUSE|MGI=MGI=88464|UniProtKB=P25318	Collagen alpha-2(VIII) chain	ISS	10778855	PubMed	PTHR44057:SF3	COLLAGEN ALPHA-2 VIII  CHAIN
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MONDO|Ensembl=ENSMODG00000014746|UniProtKB=F6YN64	Uncharacterized protein (Fragment)	ISS	12871085	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CANLF|Ensembl=ENSCAFG00000023094|UniProtKB=Q076A8	Developmental myosin heavy chain embryonic	ISS	89264452	PubMed	PTHR13140:SF427	MYOSIN-3
P02771	Pyrimidine Metabolism	P03128	Dihydrouracil Dehydrogenase	BOVIN|Gene=DPYD|UniProtKB=Q28007	Dihydropyrimidine dehydrogenase [NADP(+)]	TAS	8912928	PubMed	PTHR43073:SF2	DIHYDROPYRIMIDINE DEHYDROGENASE  NADP +
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	MACMU|Ensembl=ENSMMUG00000013303|UniProtKB=F6YY71	Retinal dehydrogenase 1	ISS			PTHR11699:SF140	RETINAL DEHYDROGENASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	HUMAN|HGNC=5292|UniProtKB=P30939	5-hydroxytryptamine receptor 1F	IDA			PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00019	Endothelin signaling pathway	P00572	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00046	Oxidative stress response	P01126	ATF2	BOVIN|Ensembl=ENSBTAG00000002295|UniProtKB=F1N177	Uncharacterized protein	ISS	10487205	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008026|UniProtKB=H2QAZ2	Syntaxin 1B	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	BOVIN|Ensembl=ENSBTAG00000014600|UniProtKB=E1BQ12	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	RAT|RGD=2743|UniProtKB=P31421	Metabotropic glutamate receptor 2	ISS	12488551	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00053	T cell activation	P01319	PAK	RAT|RGD=61953|UniProtKB=Q64303	Serine/threonine-protein kinase PAK 2	IDA	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00005	Angiogenesis	P00221	JNK1	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	ISS	11007936	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05913	Enkephalin release	P05978	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	HUMAN|HGNC=7571|UniProtKB=Q9UKX3	Myosin-13	ISS	10938134	PubMed	PTHR13140:SF504	MYOSIN-13
P00056	VEGF signaling pathway	P01417	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02752	Mannose metabolism	P03018	Mannose 1-P guanylyl transferase	PANTR|Ensembl=ENSPTRG00000014932|UniProtKB=H2QMM2	GDP-mannose pyrophosphorylase B	ISS	11082198	PubMed	PTHR22572:SF15	MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE BETA
P00056	VEGF signaling pathway	P01417	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00813	SH3GL3	HUMAN|HGNC=10832|UniProtKB=Q99963	Endophilin-A3	TAS	12932731	PubMed	PTHR43965:SF4	ENDOPHILIN-A3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00736	CalDAG-GEF	MACMU|Ensembl=ENSMMUG00000018333|UniProtKB=F6TUS1	Uncharacterized protein	ISS	10835426	PubMed	PTHR23113:SF174	RAS GUANYL-RELEASING PROTEIN 1
P00020	FAS signaling pathway	P00615	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00034	Integrin signalling pathway	P00928	alpha actinin	PANTR|Ensembl=ENSPTRG00000006477|UniProtKB=H2RDW7	Uncharacterized protein	ISS	2116421	PubMed	PTHR43947:SF3	ALPHA-ACTININ-1
P00049	Parkinson disease	P01238	14-3-3	DANRE|ZFIN=ZDB-GENE-061023-2|UniProtKB=E7F354	Uncharacterized protein	ISS	91108808	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P04393	Ras Pathway	P04556	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IDA	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04555	PDK	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MACMU|Ensembl=ENSMMUG00000003707|UniProtKB=F7GDQ6	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF58	ACTIVIN RECEPTOR TYPE-1C
P02783	Tryptophan biosynthesis	P03209	Anthranilate phosphoribosyl transferase	LEPIN|EnsemblGenome=LA_3629|UniProtKB=Q8F067	Anthranilate synthase component II	ISS			PTHR43418:SF4	MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=620308|UniProtKB=P30936	Somatostatin receptor type 3	IDA	12441358	PubMed	PTHR24229:SF42	SOMATOSTATIN RECEPTOR TYPE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00057	Wnt signaling pathway	P01429	Axin	PANTR|Ensembl=ENSPTRG00000007537|UniProtKB=H2R1H5	Uncharacterized protein	ISS	12549854	PubMed	PTHR10845:SF11	AXIN-1
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IDA	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00023	General transcription regulation	P00658	TBP-associated factors	MOUSE|MGI=MGI=2443028|UniProtKB=Q8C176	Transcription initiation factor TFIID subunit 2	ISS			PTHR15137:SF9	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00021	FGF signaling pathway	P00640	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00034	Integrin signalling pathway	P00916	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P04398	p53 pathway feedback loops 2	P04651	Ras	CHICK|Ensembl=ENSGALG00000014033|UniProtKB=E1BTS2	Uncharacterized protein	ISS	99084794	PubMed	PTHR24070:SF186	GTPASE KRAS
P00036	Interleukin signaling pathway	P00973	PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	HUMAN|HGNC=414|UniProtKB=P04075	Fructose-bisphosphate aldolase A	ISS	4812352	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00053	T cell activation	P01333	cdc42	TAKRU|Ensembl=ENSTRUG00000008289|UniProtKB=H2T7U8	Uncharacterized protein	ISS	15723050	PubMed	PTHR24072:SF129	CDC42L PROTEIN
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000011757|UniProtKB=Q9XT97	Presenilin-1	IDA	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	SCHPO|PomBase=SPBC32H8.07|UniProtKB=Q10282	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00019	Endothelin signaling pathway	P00577	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	IGI	8700226	PubMed	PTHR10048:SF14	PI-3 KINASE
P00054	Toll receptor signaling pathway	P01375	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00049	Parkinson disease	P01230	Src kinase	RAT|RGD=620795|UniProtKB=Q9WUD9	Proto-oncogene tyrosine-protein kinase Src	IDA	11078745	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00010	B cell activation	P00397	IKK	BOVIN|Ensembl=ENSBTAG00000007599|UniProtKB=Q95KV0	Inhibitor of nuclear factor kappa-B kinase subunit beta	IGI	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00034	Integrin signalling pathway	P00907	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01179	PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00091	Aph-1	ARATH|TAIR=AT2G31440|UniProtKB=Q8L9G7	Gamma-secretase subunit APH1-like	IDA	12110170	PubMed	PTHR12889:SF0	GAMMA-SECRETASE SUBUNIT APH-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=99402|UniProtKB=Q60613	Adenosine receptor A2a	IDA			PTHR24246:SF27	ADENOSINE RECEPTOR A2A
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	RAT|RGD=2345|UniProtKB=P04757	Neuronal acetylcholine receptor subunit alpha-3	IC	12098588	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P00034	Integrin signalling pathway	P00907	ERK	CHICK|Ensembl=ENSGALG00000004690|UniProtKB=Q5F3W3	Mitogen-activated protein kinase 6	ISS	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Gene=DRD2|UniProtKB=P60026	D(2) dopamine receptor	ISS	1319557	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00049	Parkinson disease	P01211	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00048	PI3 kinase pathway	P01202	p85	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00629	PP2A	CHICK|Ensembl=ENSGALG00000010273|UniProtKB=P48463	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	IC	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05913	Enkephalin release	P05977	G-Protein (s)	XENTR|Xenbase=XB-GENE-963560|UniProtKB=Q0VFC4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	PANTR|Ensembl=ENSPTRG00000018798|UniProtKB=H2QU13	Uncharacterized protein	ISS	5478218	gi	PTHR10489:SF611	C-C CHEMOKINE RECEPTOR TYPE 6
P00053	T cell activation	P01307	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00034	Integrin signalling pathway	P00936	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IPI	129387	gi	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06959	CCKR signaling map	P07114	JUN	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	RCA	20150185	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00018	EGF receptor signaling pathway	P00557	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00750	Rhodopsin kinase	HUMAN|HGNC=10013|UniProtKB=Q15835	Rhodopsin kinase	IDA	8260489	PubMed	PTHR24355:SF11	RHODOPSIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	RAT|RGD=1309725|UniProtKB=D3ZB71	Protein Dvl2	ISS	11212302	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00987	SRF	RAT|RGD=1559787|UniProtKB=D3ZHH8	Protein Srf	ISS	15647354	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	IC	176910	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	P01451	Galpha	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IDA	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	TAS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	HUMAN|HGNC=1402|UniProtKB=Q08289	Voltage-dependent L-type calcium channel subunit beta-2	IC	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00048	PI3 kinase pathway	P01185	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	MACMU|Ensembl=ENSMMUG00000014486|UniProtKB=F7GH95	Ras-related protein Rap-1A	ISS	10476970	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00057	Wnt signaling pathway	P01438	PP2A	MOUSE|MGI=MGI=1321159|UniProtKB=P63330	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1718748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00047	PDGF signaling pathway	P01164	PDK1/2	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00048	PI3 kinase pathway	P01179	PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DANRE|ZFIN=ZDB-GENE-060531-50|UniProtKB=F1R6C7	Uncharacterized protein	IEP	89264452	PubMed	PTHR13140:SF676	MYOSIN, HEAVY POLYPEPTIDE 2, FAST MUSCLE SPECIFIC
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	CANLF|Ensembl=ENSCAFG00000018230|UniProtKB=Q95LF0	Interleukin-13 receptor subunit alpha-2	TAS	11389954	PubMed	PTHR23036:SF101	INTERLEUKIN-13 RECEPTOR SUBUNIT ALPHA-2
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	HUMAN|HGNC=4580|UniProtKB=Q13002	Glutamate receptor ionotropic, kainate 2	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00053	T cell activation	P01315	Calcineurin	BOVIN|Ensembl=ENSBTAG00000016005|UniProtKB=P48452	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	IGI	12015605	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00036	Interleukin signaling pathway	P00994	FKHRL1	MACMU|Ensembl=ENSMMUG00000020369|UniProtKB=F6UMX8	Uncharacterized protein	ISS	12048180	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00139	E-cadherin transmembrane fragment	HUMAN|HGNC=1762|UniProtKB=P22223	Cadherin-3	IDA	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00029	Huntington disease	P00799	JNK-2	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	PANTR|Ensembl=ENSPTRG00000002979|UniProtKB=H2Q2M8	Uncharacterized protein	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00805	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IDA	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P06587	Nicotine pharmacodynamics pathway	P06605	KCNK3/9	CHICK|Ensembl=ENSGALG00000016193|UniProtKB=E1BYI0	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00049	Parkinson disease	P01235	Fyn kinase	MOUSE|MGI=MGI=95602|UniProtKB=P39688	Tyrosine-protein kinase Fyn	IDA	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00020	FAS signaling pathway	P00601	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	3136397	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00029	Huntington disease	P00775	Rac	BOVIN|Ensembl=ENSBTAG00000013749|UniProtKB=F1MK42	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF13	RHO-RELATED GTP-BINDING PROTEIN RHOQ
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	RCA			PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00019	Endothelin signaling pathway	P00583	cPLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000000365|UniProtKB=F6R9F4	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00050	Plasminogen activating cascade	P01255	Plasminogen	HUMAN|HGNC=9071|UniProtKB=P00747	Plasminogen	IDA	2318848	PubMed	PTHR24261:SF6	PLASMINOGEN
P04393	Ras Pathway	P04542	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00807	Actin	USTMA|Gene=UMAG_11232|UniProtKB=A0A0D1DMT3	Chromosome 22, whole genome shotgun sequence	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00048	PI3 kinase pathway	P01177	P110ACT	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CHICK|Ensembl=ENSGALG00000000168|UniProtKB=P49892	Adenosine receptor A1	IDA	12515326	PubMed	PTHR24246:SF1	ADENOSINE RECEPTOR A1
P00005	Angiogenesis	P00219	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_56687|UniProtKB=C3YC50	Putative uncharacterized protein	IDA	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01451	Galpha	HUMAN|HGNC=4383|UniProtKB=P30679	Guanine nucleotide-binding protein subunit alpha-15	IDA	11534853	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	11956331	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00009	Axon guidance mediated by netrin	P00366	Rac	CHICK|Ensembl=ENSGALG00000002859|UniProtKB=F6UBD2	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	PLAF7|EnsemblGenome=PF11_0377|UniProtKB=Q8IHZ9	Casein kinase I	IDA	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=628675|UniProtKB=Q9Z2A6	Mitogen-activated protein kinase 15	TAS	10514528	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00017	DNA replication	P00527	Histones	BOVIN|Ensembl=ENSBTAG00000024003|UniProtKB=E1BGN3	Histone H3	ISS	20448842	PubMed	PTHR11426:SF180	SUBFAMILY NOT NAMED
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=628675|UniProtKB=Q9Z2A6	Mitogen-activated protein kinase 15	IDA	12787066	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00010	B cell activation	P00402	Jnk	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00019	Endothelin signaling pathway	P00586	Gq	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	TAS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02918	dUTP pyrophosphatase	HUMAN|HGNC=3078|UniProtKB=P33316	Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial	ISS			PTHR11241:SF6	DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE, MITOCHONDRIAL
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00018	EGF receptor signaling pathway	P00564	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12912997	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	CHICK|Gene=MYCN|UniProtKB=P18444	N-myc proto-oncogene protein	IEP	12356903	PubMed	PTHR11514:SF3	N-MYC PROTO-ONCOGENE PROTEIN
P00019	Endothelin signaling pathway	P00572	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00001	Adrenaline and noradrenaline biosynthesis	P00061	PNMT	RAT|RGD=1309606|UniProtKB=D4A605	Nicotinamide N-methyltransferase (Predicted)	ISS			PTHR10867:SF5	NICOTINAMIDE N-METHYLTRANSFERASE
P00017	DNA replication	P00527	Histones	SCHMA|EnsemblGenome=Smp_074610|UniProtKB=C4QHD7	Histone H3	ISS	12413958	PubMed	PTHR11426:SF20	HISTONE H3-LIKE CENTROMERIC PROTEIN A
P02738	De novo purine biosynthesis	P02902	ADP reductase	TRYB2|Gene=Tb11.v4.0004|UniProtKB=Q382Q3	Ribonucleoside-diphosphate reductase small chain	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00019	Endothelin signaling pathway	P00591	PLCbeta	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00057	Wnt signaling pathway	P01438	PP2A	XENTR|Xenbase=XB-GENE-957248|UniProtKB=Q6GLE6	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P02747	Histidine biosynthesis	P02992	Imidazol glycerol phosphate synthase	NEUCR|EnsemblGenome=EFNCRG00000007259|UniProtKB=Q1K5X9	Imidazole glycerol phosphate synthase hisHF	ISS			PTHR21235:SF2	IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF
P00058	mRNA splicing	P01479	U1	ARATH|TAIR=AT2G47580|UniProtKB=Q39244	U1 small nuclear ribonucleoprotein A	ISS			PTHR10501:SF40	U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A
P00034	Integrin signalling pathway	P00942	Fyn	PANTR|Ensembl=ENSPTRG00000018511|UniProtKB=H2QTK7	Tyrosine-protein kinase	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04455	beta-endorphin	DANRE|ZFIN=ZDB-GENE-041014-294|UniProtKB=Q5SPP4	Uncharacterized protein	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00019	Endothelin signaling pathway	P00589	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	IGI	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00310	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00046	Oxidative stress response	P01126	ATF2	PANTR|Ensembl=ENSPTRG00000012660|UniProtKB=H2QJ07	Activating transcription factor 2	ISS	15218628	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P04393	Ras Pathway	P04557	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	IDA	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	DROME|FlyBase=FBgn0028875|UniProtKB=Q7KT97	Nicotinic acetylcholine receptor alpha5, isoform B	ISS	11404397	PubMed	PTHR18945:SF770	NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA5, ISOFORM B
P00029	Huntington disease	P00801	Fos protein	CANLF|Ensembl=ENSCAFG00000017040|UniProtKB=E2QYK5	Uncharacterized protein	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00021	FGF signaling pathway	P00634	MEKK1-5	PANTR|Ensembl=ENSPTRG00000024326|UniProtKB=H2R231	Uncharacterized protein	ISS	11730323	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00006	Apoptosis signaling pathway	P00310	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IDA	1171954	gi	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	DANRE|Ensembl=ENSDARG00000024785|UniProtKB=B7ZC77	Catenin alpha-2	ISS	1768802	PubMed	PTHR18914:SF29	CATENIN ALPHA-2
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00029	Huntington disease	P00790	beta-Tubulin	CAEEL|WormBase=WBGene00006537|UniProtKB=P52275	Tubulin beta-2 chain	TAS	9454836	PubMed	PTHR11588:SF84	TUBULIN BETA-2 CHAIN
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	TAKRU|Ensembl=ENSTRUG00000017138|UniProtKB=H2V3X9	Protein Wnt	TAS	8717036	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00049	Parkinson disease	P01234	GRK	CANLF|Ensembl=ENSCAFG00000011733|UniProtKB=E2R5J6	Protein-serine/threonine kinase	ISS	10852916	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P00021	FGF signaling pathway	P00644	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IGI	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	PANTR|Ensembl=ENSPTRG00000023608|UniProtKB=H2QZZ2	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	RAT|RGD=619933|UniProtKB=Q5I0L5	C-C motif chemokine	IDA	12629149	PubMed	PTHR12015:SF102	C-C MOTIF CHEMOKINE 22
P04393	Ras Pathway	P04556	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04546	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	IDA	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT3G18040|UniProtKB=Q9LV37	Mitogen-activated protein kinase 9	IDA			PTHR24055:SF246	MITOGEN-ACTIVATED PROTEIN KINASE 15-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	PANTR|Ensembl=ENSPTRG00000008014|UniProtKB=H2QAY4	Phosphorylase kinase, gamma 2 (Testis)	ISS	1370475	PubMed	PTHR44087:SF2	PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, LIVER/TESTIS ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	RCA			PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00005	Angiogenesis	P00204	PLD	CANLF|Ensembl=ENSCAFG00000015246|UniProtKB=J9P1D8	Uncharacterized protein	ISS	10497874	PubMed	PTHR18896:SF57	PHOSPHOLIPASE D1
P00052	TGF-beta signaling pathway	P01292	RSmads	ORNAN|Ensembl=ENSOANG00000006538|UniProtKB=F6YA42	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00034	Integrin signalling pathway	P00922	Collagen	MOUSE|MGI=MGI=894686|UniProtKB=A2ACT7	Procollagen, type IX, alpha 3	IDA	10778855	PubMed	PTHR44865:SF1	COLLAGEN ALPHA-3 IX  CHAIN
P00049	Parkinson disease	P01242	Casein kinase I	PANTR|Ensembl=ENSPTRG00000017182|UniProtKB=H2RAT8	Casein kinase 1, gamma 3	ISS	10617630	PubMed	PTHR11909:SF151	CASEIN KINASE I ISOFORM GAMMA-3
P00047	PDGF signaling pathway	P01160	IP3 receptor	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00056	VEGF signaling pathway	P01421	Rac	MACMU|Ensembl=ENSMMUG00000031000|UniProtKB=F6Y6A5	Uncharacterized protein	ISS			PTHR23176:SF3	PROTEIN PRR5-ARHGAP8-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00012	Cadherin signaling pathway	P00474	Wnt	MACMU|Ensembl=ENSMMUG00000001325|UniProtKB=F7BGU5	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00047	PDGF signaling pathway	P01142	p90RSK	CANLF|Ensembl=ENSCAFG00000000828|UniProtKB=F6UWI0	Ribosomal protein S6 kinase	ISS	1922062	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00049	Parkinson disease	P01227	20S proteasome	MONDO|Ensembl=ENSMODG00000007839|UniProtKB=F7ETB2	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF10	PROTEASOME SUBUNIT ALPHA TYPE-3
P00010	B cell activation	P00386	Calcineurin	MOUSE|MGI=MGI=107162|UniProtKB=P48455	Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform	IDA	7532676	PubMed	PTHR11668:SF186	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT GAMMA ISOFORM
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	HUMAN|HGNC=6697|UniProtKB=O75197	Low-density lipoprotein receptor-related protein 5	IDA	11907044	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CAEBR|Gene=CBG04190|UniProtKB=A8WWD7	Protein CBR-MEK-2	ISS	12024031	PubMed	PTHR24361:SF629	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1
P00049	Parkinson disease	P01211	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8699|UniProtKB=O60330	Protocadherin gamma-A12	IDA	8120095	PubMed	PTHR24028:SF227	PROTOCADHERIN GAMMA-A12
P00059	p53 pathway	P04609	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	ISS	96009592	PubMed	PTHR10048:SF14	PI-3 KINASE
P00012	Cadherin signaling pathway	P00475	Frizzled	CANLF|Ensembl=ENSCAFG00000008293|UniProtKB=E2R9M9	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF22	FRIZZLED-3
P00052	TGF-beta signaling pathway	P01286	TGFbeta	BOVIN|Ensembl=ENSBTAG00000012870|UniProtKB=E1BGS3	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF139	BONE MORPHOGENETIC PROTEIN 5
P00019	Endothelin signaling pathway	P00568	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	ARATH|TAIR=AT5G23860|UniProtKB=P29516	Tubulin beta-8 chain	ISS	12932731	PubMed	PTHR11588:SF264	TUBULIN BETA-8 CHAIN
P00046	Oxidative stress response	P01135	p38	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P02741	Flavin biosynthesis	P02940	Riboflavin synthase	LEPIN|EnsemblGenome=LA_1145|UniProtKB=Q8F703	Riboflavin synthase subunit alpha	ISS			PTHR21098:SF0	RIBOFLAVIN SYNTHASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	RAT|RGD=2257|UniProtKB=P62161	Calmodulin	ISS	3885394	PubMed	PTHR23050:SF311	CALMODULIN
P00012	Cadherin signaling pathway	P00470	F-actin	XENTR|Xenbase=XB-GENE-493937|UniProtKB=Q5M8T9	Actin, alpha 2, smooth muscle, aorta	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00020	FAS signaling pathway	P00616	Nuclear Lamin	XENTR|Xenbase=XB-GENE-920722|UniProtKB=F6YQA9	Uncharacterized protein	ISS	11165516	PubMed	PTHR23239:SF158	PRELAMIN-A/C
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00840	GPRK	MACMU|Ensembl=ENSMMUG00000019817|UniProtKB=F7FY63	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P00029	Huntington disease	P00780	Microtubule	TRYB2|Gene=TB927.1.2330|UniProtKB=Q4GYY6	Beta tubulin	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	HUMAN|HGNC=9992|UniProtKB=O43665	Regulator of G-protein signaling 10	IDA	8756726	PubMed	PTHR10845:SF182	REGULATOR OF G-PROTEIN SIGNALING 10
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	CHICK|Ensembl=ENSGALG00000013785|UniProtKB=E1BS74	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P02775	Salvage pyrimidine ribonucleotides	P03149	Cytidine kinase	ANOGA|EnsemblGenome=AGAP005209|UniProtKB=Q5TSQ7	Uridine kinase	ISS			PTHR10285:SF123	URIDINE KINASE
P00007	Axon guidance mediated by semaphorins	P00340	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00038	JAK/STAT signaling pathway	P01027	STAT	RAT|RGD=3772|UniProtKB=P52631	Signal transducer and activator of transcription 3	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=1310389|UniProtKB=D3ZTF6	Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Predicted), isoform CRA_a	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02783	Tryptophan biosynthesis	P03206	Anthranilate synthase	MYCTU|EnsemblGenome=Rv1609|UniProtKB=P9WFX3	Anthranilate synthase component 1	ISS			PTHR11236:SF9	ANTHRANILATE SYNTHASE COMPONENT 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	DANRE|ZFIN=ZDB-GENE-081006-1|UniProtKB=F1Q9W3	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	SCLS1|EnsemblGenome=SS1G_03482|UniProtKB=A7EDU2	Guanine nucleotide-binding protein beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00038	JAK/STAT signaling pathway	P01027	STAT	RAT|RGD=3772|UniProtKB=P52631	Signal transducer and activator of transcription 3	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04397	p53 pathway by glucose deprivation	P04639	AMPK	CHICK|Ensembl=ENSGALG00000014832|UniProtKB=Q2PUH1	5'-AMP-activated protein kinase alpha-1 catalytic subunit	ISS			PTHR24343:SF306	5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P02748	Isoleucine biosynthesis	P02994	Branched chain amino acid aminotransferase	MYCTU|EnsemblGenome=Rv2210c|UniProtKB=P9WQ75	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF44	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P00006	Apoptosis signaling pathway	P00264	c-IAP1,2	RAT|RGD=620690|UniProtKB=Q6P6S1	Baculoviral IAP repeat-containing 2	ISS			PTHR10044:SF79	BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 2
P00054	Toll receptor signaling pathway	P01356	ERK2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IGI	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	RAT|RGD=1310826|UniProtKB=Q5M7U6	Actin-related protein 2	ISS	10974003	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00402	Jnk	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00053	T cell activation	P01300	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01435	SWI/SNF	MOUSE|MGI=MGI=1927347|UniProtKB=O54941	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1	IDA	11532957	PubMed	PTHR13711:SF206	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY E MEMBER 1
P00050	Plasminogen activating cascade	P01253	Fibrin	PANTR|Ensembl=ENSPTRG00000016535|UniProtKB=H2QQB5	Uncharacterized protein	ISS	4503689	gi	PTHR19143:SF232	FIBRINOGEN ALPHA CHAIN
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04397	p53 pathway by glucose deprivation	P04641	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02759	Pyridoxal-5-phosphate biosynthesis	P03061	Pyridoxine-5-phosphate oxidase	BOVIN|Ensembl=ENSBTAG00000012259|UniProtKB=Q5E9K3	Pyridoxine-5'-phosphate oxidase	ISS	9601034	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00009	Axon guidance mediated by netrin	P00366	Rac	MACMU|Ensembl=ENSMMUG00000021075|UniProtKB=F7GY91	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00019	Endothelin signaling pathway	P00577	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IGI	7565716	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DICDI|dictyBase=DDB_G0283907|UniProtKB=P34099	cAMP-dependent protein kinase catalytic subunit	IC	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00047	PDGF signaling pathway	P01154	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P02740	De novo pyrimidine ribonucleotides biosythesis	P02922	Orotate phosphoribosyltransferase	SULSO|EnsemblGenome=SSO0615|UniProtKB=Q9UX09	Orotate phosphoribosyltransferase	ISS			PTHR19278:SF49	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	8946911	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00036	Interleukin signaling pathway	P00990	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IC	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04392	P53 pathway feedback loops 1	P04539	p53	MOUSE|MGI=MGI=98834|UniProtKB=P02340	Cellular tumor antigen p53	TAS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00053	T cell activation	P01311	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01162	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P02762	Pentose phosphate pathway	P03070	Gluconate Dehydrogenase	DICDI|dictyBase=DDB_G0277885|UniProtKB=Q8TA03	6-phosphogluconate dehydrogenase, decarboxylating	ISS	11818061	PubMed	PTHR11811:SF25	6-PHOSPHOGLUCONATE DEHYDROGENASE, DECARBOXYLATING
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MACMU|Ensembl=ENSMMUG00000011208|UniProtKB=F6UKG6	Uncharacterized protein	ISS	12809600	PubMed	PTHR16290:SF4	MRNA-DECAPPING ENZYME 1A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	MACMU|Ensembl=ENSMMUG00000009054|UniProtKB=F7F735	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1203729|UniProtKB=Q61194	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00010	B cell activation	P00371	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	RAT|RGD=3425|UniProtKB=P97887	Presenilin-1	IDA	12736250	PubMed	PTHR10202:SF18	PRESENILIN-1
P00052	TGF-beta signaling pathway	P01292	RSmads	MONDO|Ensembl=ENSMODG00000010017|UniProtKB=F6UAA8	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF41	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 9
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00005	Angiogenesis	P00254	GTPase	BOVIN|Ensembl=ENSBTAG00000004279|UniProtKB=P61585	Transforming protein RhoA	ISS	12169092	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00029	Huntington disease	P00778	NMDA receptor	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	HUMAN|HGNC=2514|UniProtKB=P35222	Catenin beta-1	TAS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05938	RhoA	MONDO|Ensembl=ENSMODG00000012981|UniProtKB=F7CS91	Uncharacterized protein	ISS	15668138	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	MOUSE|MGI=MGI=95801|UniProtKB=O70291	G protein-coupled receptor kinase 4	RCA			PTHR24355:SF14	G PROTEIN-COUPLED RECEPTOR KINASE 4
P00006	Apoptosis signaling pathway	P00302	ATF	BOVIN|Ensembl=ENSBTAG00000018131|UniProtKB=Q08DA8	Cyclic AMP-dependent transcription factor ATF-1	ISS	11390664	PubMed	PTHR22952:SF258	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-1
P04393	Ras Pathway	P04570	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	USTMA|Gene=UMAG_03910|UniProtKB=A0A0D1DU81	Chromosome 11, whole genome shotgun sequence	ISS			PTHR23050:SF245	AT16150P-RELATED
P02742	Tetrahydrofolate biosynthesis	P02951	GTP cyclohydrolase	MACMU|Ensembl=ENSMMUG00000004084|UniProtKB=F6ZD19	Uncharacterized protein	ISS			PTHR11109:SF0	GTP CYCLOHYDROLASE 1
P06211	BMP/activin signaling pathway-drosophila	P06245	R-Smad	DROME|FlyBase=FBgn0011648|UniProtKB=P42003	Protein mothers against dpp	RCA	9395284	PubMed	PTHR13703:SF40	PROTEIN MOTHERS AGAINST DPP
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00047	PDGF signaling pathway	P01173	STAT	HUMAN|HGNC=11367|UniProtKB=P51692	Signal transducer and activator of transcription 5B	ISS	95236292	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00010	B cell activation	P00383	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00059	p53 pathway	G01575	GADD45	HUMAN|HGNC=4097|UniProtKB=O95257	Growth arrest and DNA damage-inducible protein GADD45 gamma	IGI	10097101	PubMed	PTHR10411:SF4	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 GAMMA
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	ORNAN|Ensembl=ENSOANG00000007724|UniProtKB=F6QTB5	Uncharacterized protein	ISS	12473693	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	TAKRU|Ensembl=ENSTRUG00000009851|UniProtKB=H2TJ90	Uncharacterized protein	IGI	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=99842|UniProtKB=Q02284	5-hydroxytryptamine receptor 1F	IDA	12441358	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00048	PI3 kinase pathway	P01187	IR	PANTR|Ensembl=ENSPTRG00000010386|UniProtKB=H2QF61	Tyrosine-protein kinase receptor	ISS	2983222	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	TAS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IDA	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05913	Enkephalin release	P05974	G-Protein (i)	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	TAKRU|Ensembl=ENSTRUG00000016101|UniProtKB=H2UW32	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MONDO|Ensembl=ENSMODG00000012009|UniProtKB=F7AMI2	Uncharacterized protein	ISS			PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00551	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02728	Arginine biosynthesis	P02841	argininosuccinate lyase	STRCO|EnsemblGenome=CAB76090|UniProtKB=Q9L1B1	Argininosuccinate lyase	ISS			PTHR43814:SF1	ARGININOSUCCINATE LYASE
P00005	Angiogenesis	P00226	Delta/Serrate	BOVIN|Ensembl=ENSBTAG00000010361|UniProtKB=Q0V7L8	Delta-like protein	ISS	11798067	PubMed	PTHR24044:SF320	DELTA-LIKE PROTEIN 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	XENTR|Xenbase=XB-GENE-969601|UniProtKB=Q28H40	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04393	Ras Pathway	P04557	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	IDA	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05731	GABA-B receptor II signaling	P05754	Ggamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IDA	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00036	Interleukin signaling pathway	P00976	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P05912	Dopamine receptor mediated signaling pathway	P05949	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12162872	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01305	Calmodulin	TAKRU|Ensembl=ENSTRUG00000008685|UniProtKB=H2TXN3	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF326	CALMODULIN
P00021	FGF signaling pathway	P00629	PP2A	DANRE|ZFIN=ZDB-GENE-040426-2086|UniProtKB=Q6NY64	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform	ISS	11956189	PubMed	PTHR11871:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B DELTA ISOFORM
P04393	Ras Pathway	P04552	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	XENTR|Xenbase=XB-GENE-494200|UniProtKB=F7CS79	Uncharacterized protein	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00012	Cadherin signaling pathway	P00471	Cadherin	DROME|FlyBase=FBgn0036715|UniProtKB=Q9VVG0	Cadherin 74A, isoform A	ISS	8120095	PubMed	PTHR43956:SF5	CADHERIN 74A, ISOFORM A
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	ISS	12660731	PubMed	PTHR10048:SF14	PI-3 KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	BOVIN|Ensembl=ENSBTAG00000014828|UniProtKB=F1N1E0	Uncharacterized protein	ISS	8386525	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PRIPA|Gene=PPA17339|UniProtKB=H3F5B4	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF352	ACTIN
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	DANRE|ZFIN=ZDB-GENE-030131-8013|UniProtKB=F1QBT6	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	BOVIN|Gene=DRD2|UniProtKB=P20288	D(2) dopamine receptor	ISS	11248120	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CAEEL|WormBase=WBGene00000047|UniProtKB=Q23355	AcetylCholine Receptor	IC			PTHR18945:SF758	NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA3, ISOFORM B
P04398	p53 pathway feedback loops 2	P04657	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00021	FGF signaling pathway	P00624	14-3-3	PANTR|Ensembl=ENSPTRG00000008521|UniProtKB=G2HI54	14-3-3 protein epsilon	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	IC	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00057	Wnt signaling pathway	P01432	Beta-Catenin	BOVIN|Ensembl=ENSBTAG00000016420|UniProtKB=Q0VCX4	Catenin beta-1	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MOUSE|MGI=MGI=2152453|UniProtKB=Q2NL51	Glycogen synthase kinase-3 alpha	ISS	14698990	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00012	Cadherin signaling pathway	P00462	Casein kinase II	CHICK|Ensembl=ENSGALG00000000889|UniProtKB=R9PXL1	Uncharacterized protein	ISS	10806215	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000009766|UniProtKB=F6TFL4	Uncharacterized protein	ISS	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00034	Integrin signalling pathway	P00936	PI3K	ANOGA|Gene=AgaP_AGAP010273|UniProtKB=Q7PMF0	Phosphatidylinositol 3-kinase	IPI	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04398	p53 pathway feedback loops 2	P04665	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00907	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	176948	OMIM	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MONDO|Ensembl=ENSMODG00000004422|UniProtKB=F6SCX2	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF344	MYOSIN-7
P00056	VEGF signaling pathway	P01409	cPLA2	CANLF|Ensembl=ENSCAFG00000013778|UniProtKB=F6UQ33	Phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00029	Huntington disease	P00806	TAFII130	DROME|FlyBase=FBgn0041103|UniProtKB=Q9VJP5	IP01149p	IDA	10973244	PubMed	PTHR15138:SF14	IP01149P-RELATED
P00029	Huntington disease	P00801	Fos protein	CANLF|Ensembl=ENSCAFG00000017040|UniProtKB=E2QYK5	Uncharacterized protein	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P05734	Synaptic vesicle trafficking	P05779	Synaptobrevin	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00047	PDGF signaling pathway	P01142	p90RSK	HUMAN|HGNC=10434|UniProtKB=O75582	Ribosomal protein S6 kinase alpha-5	ISS	9687510	PubMed	PTHR24351:SF115	RIBOSOMAL PROTEIN S6 KINASE ALPHA-5
P00038	JAK/STAT signaling pathway	P01034	Jak	MACMU|Ensembl=ENSMMUG00000018566|UniProtKB=F6YLX1	Tyrosine-protein kinase	ISS	9637709	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00059	p53 pathway	P04630	PP2A	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g195622|UniProtKB=A7T2Q5	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00521	Profilin	BOVIN|Ensembl=ENSBTAG00000004915|UniProtKB=P02584	Profilin-1	ISS			PTHR13936:SF14	PROFILIN-1
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01446	Calcineurin	DROME|FlyBase=FBgn0011826|UniProtKB=Q27889	Serine/threonine-protein phosphatase 2B catalytic subunit 2	IDA	12015605	PubMed	PTHR11668:SF118	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED
P00034	Integrin signalling pathway	P00951	Jnk	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	IDA	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00046	Oxidative stress response	P01122	TRX	MACMU|Gene=TXN|UniProtKB=P29451	Thioredoxin	TAS	12115731	PubMed	PTHR10438:SF18	THIOREDOXIN
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	IC	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	HUMAN|HGNC=145|UniProtKB=P63267	Actin, gamma-enteric smooth muscle	IEP	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	TRIAD|EnsemblGenome=TriadG37105|UniProtKB=B3RJX8	Calmodulin	ISS	3885394	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00036	Interleukin signaling pathway	P00986	eNOS	HUMAN|HGNC=7876|UniProtKB=P29474	Nitric oxide synthase, endothelial	ISS	93055452	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	BOVIN|Ensembl=ENSBTAG00000004216|UniProtKB=F1MSX4	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P05918	p38 MAPK pathway	P06024	eIF4E	RAT|RGD=69647|UniProtKB=P63074	Eukaryotic translation initiation factor 4E	ISS			PTHR11960:SF14	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	MOUSE|MGI=MGI=87941|UniProtKB=Q3UYH7	Beta-adrenergic receptor kinase 2	ISS	8288567	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00034	Integrin signalling pathway	P00941	Integrin alpha	MOUSE|MGI=MGI=102700|UniProtKB=Q61738	Integrin alpha-7	IPI	3487386	PubMed	PTHR23220:SF90	INTEGRIN ALPHA-7
P02788	Xanthine and guanine salvage pathway	P03247	Xanthine phosphoribosyl transferase	PANTR|Gene=HPRT1|UniProtKB=A5A6I1	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF6	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE
P00011	Blood coagulation	P00458	GP IIIa	BOVIN|Ensembl=ENSBTAG00000009987|UniProtKB=F1MTN1	Integrin beta	ISS	386150	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00010	B cell activation	P00383	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CAEEL|WormBase=WBGene00004038|UniProtKB=Q22070	Phosphoinositide phospholipase C	ISS			PTHR10336:SF91	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IC	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00006	Apoptosis signaling pathway	P00310	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	IC	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00897	SHIP2	BOVIN|Ensembl=ENSBTAG00000019167|UniProtKB=E1BBJ7	Uncharacterized protein	ISS	12145149	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01242	Casein kinase I	XENTR|Xenbase=XB-GENE-5733929|UniProtKB=Q6P647	Casein kinase I isoform delta	ISS	11437445	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00006	Apoptosis signaling pathway	P00313	IKK	CANLF|Ensembl=ENSCAFG00000005526|UniProtKB=E2RKR0	Uncharacterized protein	ISS	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00048	PI3 kinase pathway	P01179	PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00778	NMDA receptor	RAT|RGD=2740|UniProtKB=Q62645	Glutamate receptor ionotropic, NMDA 2D	IDA	11554549	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00046	Oxidative stress response	P01131	MKP5	CHICK|Ensembl=ENSGALG00000003706|UniProtKB=F1NPP0	Dual specificity protein phosphatase	TAS			PTHR10159:SF309	DUAL SPECIFICITY PROTEIN PHOSPHATASE 1
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05915	Opioid proenkephalin pathway	P05993	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00029	Huntington disease	P00805	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00005	Angiogenesis	P00217	STAT3	CHICK|Ensembl=ENSGALG00000003267|UniProtKB=Q6DV79	Signal transducer and activator of transcription 3	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00057	Wnt signaling pathway	P01456	beta-arrestin	HUMAN|HGNC=10521|UniProtKB=P10523	S-arrestin	IC	10206946	PubMed	PTHR11792:SF15	S-ARRESTIN
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00048	PI3 kinase pathway	P01179	PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00049	Parkinson disease	P01242	Casein kinase I	CAEEL|WormBase=WBGene00011283|UniProtKB=Q22033	Uncharacterized protein	IDA	11437445	PubMed	PTHR11909:SF19	ASATOR, ISOFORM D
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	HUMAN|HGNC=1388|UniProtKB=O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	14507926	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00819	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00624	14-3-3	PANTR|Ensembl=ENSPTRG00000011641|UniProtKB=H2QHF1	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	ISS	10407019	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P04393	Ras Pathway	P04556	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00217	STAT3	CHICK|Ensembl=ENSGALG00000003267|UniProtKB=Q6DV79	Signal transducer and activator of transcription 3	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	BACSU|EnsemblGenome=BSU27260|UniProtKB=O05393	O-acetylserine dependent cystathionine beta-synthase	ISS			PTHR10314:SF159	CYSTEINE SYNTHASE A
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00021	FGF signaling pathway	P00632	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	BRAFL|Gene=BRAFLDRAFT_115565|UniProtKB=C3XYD3	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P04380	Cortocotropin releasing factor receptor signaling pathway	G04671	proopiomelanocortin	XENTR|Xenbase=XB-GENE-483703|UniProtKB=Q5M8F2	Proopiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00633	Ras	PANTR|Ensembl=ENSPTRG00000034469|UniProtKB=H2Q2V0	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	SYNY3|EnsemblGenome=BAA18596|UniProtKB=P74494	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=2685045|UniProtKB=E9QAN8	Protein Pik3c2b	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MOUSE|MGI=MGI=1194495|UniProtKB=O08790	Formyl peptide receptor-related sequence 1	IC			PTHR24225:SF0	N-FORMYL PEPTIDE RECEPTOR 2
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	RAT|RGD=61953|UniProtKB=Q64303	Serine/threonine-protein kinase PAK 2	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g188243|UniProtKB=A7SCN8	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	IC	11035810	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00021	FGF signaling pathway	P00645	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00810	GAPDH	TRYB2|Gene=Tb10.6k15.3850|UniProtKB=Q38AR9	Glyceraldehyde-3-phosphate dehydrogenase	IPI			PTHR10836:SF76	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE A
P00053	T cell activation	P01300	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01407	Erk	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00752	cGMP-gated ion channel	CHICK|Ensembl=ENSGALG00000014136|UniProtKB=Q90980	Cyclic nucleotide-gated channel rod photoreceptor subunit alpha	IDA	12432397	PubMed	PTHR10217:SF387	CYCLIC NUCLEOTIDE-GATED CHANNEL ROD PHOTORECEPTOR SUBUNIT ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01200	SHIP	MOUSE|MGI=MGI=2686961|UniProtKB=E9QAS7	Protein Inpp5a	ISS			PTHR12997:SF2	TYPE I INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P02754	Methylcitrate cycle	P03028	Aconitase	ECOLI|EcoGene=EG11325|UniProtKB=P25516	Aconitate hydratase A	ISS			PTHR11670:SF1	ACONITATE HYDRATASE
P00056	VEGF signaling pathway	P01407	Erk	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01159	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00006	Apoptosis signaling pathway	P00280	PACT	RAT|RGD=1306707|UniProtKB=Q4V8C7	Interferon-inducible double-stranded RNA-dependent protein kinase activator A	ISS	10988289	PubMed	PTHR10910:SF8	INTERFERON-INDUCIBLE DOUBLE-STRANDED RNA-DEPENDENT PROTEIN KINASE ACTIVATOR A
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CANLF|Ensembl=ENSCAFG00000004930|UniProtKB=E2RFB5	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P06959	CCKR signaling map	P07187	Beta-arrestin-1/2	HUMAN|HGNC=4164|UniProtKB=P01350	Gastrin	RCA	21156802	PubMed	PTHR19309:SF0	GASTRIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-8225|UniProtKB=Q7SZZ5	Uncharacterized protein	ISS			PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	RCA	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00019	Endothelin signaling pathway	P00588	ET1-4	HUMAN|HGNC=3176|UniProtKB=P05305	Endothelin-1	ISS	15117818	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	XENTR|Xenbase=XB-GENE-969601|UniProtKB=Q28H40	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P02769	Purine metabolism	P03116	Xanthine Oxidase	PANTR|Ensembl=ENSPTRG00000011806|UniProtKB=H2QHQ2	Uncharacterized protein	ISS	8708081	PubMed	PTHR11908:SF80	XANTHINE DEHYDROGENASE/OXIDASE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	HUMAN|HGNC=1403|UniProtKB=P54284	Voltage-dependent L-type calcium channel subunit beta-3	IC			PTHR11824:SF8	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-3
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	DEIRA|EnsemblGenome=DR_B0108|UniProtKB=Q9RZL7	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	DANRE|ZFIN=ZDB-GENE-990415-199|UniProtKB=A3QJX7	Uncharacterized protein	IDA	12093103	PubMed	PTHR24229:SF74	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000003128|UniProtKB=H2Q2V4	Uncharacterized protein	ISS	2137198	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P04393	Ras Pathway	P04559	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00021	FGF signaling pathway	P00628	JNK1-3	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IGI	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00634	MEKK1-5	MACMU|Ensembl=ENSMMUG00000012387|UniProtKB=F7EB20	Uncharacterized protein	ISS	8940199	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00005	Angiogenesis	P00254	GTPase	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	ISS	12039949	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P02738	De novo purine biosynthesis	P02898	Phosphoribosylformylglycinamide  synthase	PYRAE|EnsemblGenome=PAE0225|UniProtKB=Q8ZZJ7	Phosphoribosylformylglycinamidine synthase subunit PurL	ISS			PTHR43555:SF1	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01465	Ggamma	PANTR|Ensembl=ENSPTRG00000000843|UniProtKB=H2QZN8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00023	General transcription regulation	P00658	TBP-associated factors	ARATH|TAIR=AT1G54140|UniProtKB=Q9SYH2	Transcription initiation factor TFIID subunit 9	ISS			PTHR12595:SF6	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 9
P04393	Ras Pathway	P04561	SRF	BOVIN|Ensembl=ENSBTAG00000012777|UniProtKB=E1BJP4	Uncharacterized protein	ISS	15170389	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02770	Pyridoxal phosphate salvage pathway	P03121	Pyridoxal kinase	YEAST|SGD=S000000755|UniProtKB=P39988	Putative pyridoxal kinase BUD16	ISS			PTHR10534:SF2	PYRIDOXAL KINASE
P00021	FGF signaling pathway	P00629	PP2A	RAT|RGD=1308022|UniProtKB=D3ZDI7	Protein Ppp2r5a	ISS	12110603	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00379	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00019	Endothelin signaling pathway	P00566	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	TAKRU|Ensembl=ENSTRUG00000013411|UniProtKB=H2UB84	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00057	Wnt signaling pathway	P01446	Calcineurin	ORYSJ|EnsemblGenome=OS12G0597000|UniProtKB=Q3HRP5	Calcineurin B-like protein 2	ISS	12015605	PubMed	PTHR23056:SF57	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05731	GABA-B receptor II signaling	P05754	Ggamma	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00019	Endothelin signaling pathway	P00568	PKC	DANRE|ZFIN=ZDB-GENE-041001-104|UniProtKB=Q5TZD4	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF31	SUBFAMILY NOT NAMED
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	METJA|EnsemblGenome=MJ_1378|UniProtKB=Q58773	Carbamoyl-phosphate synthase large chain, N-terminal section	ISS			PTHR11405:SF5	CAD PROTEIN
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	DANRE|ZFIN=ZDB-GENE-051202-1|UniProtKB=E7F101	Uncharacterized protein	ISS	11554554	PubMed	PTHR44391:SF2	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MACMU|Ensembl=ENSMMUG00000012054|UniProtKB=F6TII3	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	TAKRU|Ensembl=ENSTRUG00000003520|UniProtKB=H2S791	Uncharacterized protein	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	MACMU|Ensembl=ENSMMUG00000001060|UniProtKB=F6QN17	Uncharacterized protein	ISS	8930069	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00005	Angiogenesis	P00219	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	CANLF|Ensembl=ENSCAFG00000015094|UniProtKB=F1PT97	Uncharacterized protein	ISS	12963527	gi	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04395	Vasopressin synthesis	P04590	Vasopressin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00056	VEGF signaling pathway	P01407	Erk	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	RAT|RGD=628817|UniProtKB=Q8K4C8	Frizzled homolog 9 (Drosophila)	ISS	11212302	PubMed	PTHR11309:SF79	FRIZZLED-9
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02776	Serine glycine biosynthesis	P03157	Phosphoserine aminotransferase	PSEAE|EnsemblGenome=PA3167|UniProtKB=Q9HZ66	Phosphoserine aminotransferase	ISS			PTHR43247:SF2	PHOSPHOSERINE AMINOTRANSFERASE
P00034	Integrin signalling pathway	P00942	Fyn	TAKRU|Ensembl=ENSTRUG00000003538|UniProtKB=H2S7D1	Tyrosine-protein kinase	ISS	11162638	PubMed	PTHR24418:SF242	TYROSINE-PROTEIN KINASE FYNB
P00041	Metabotropic glutamate receptor group I pathway	P01058	Homer	BOVIN|Ensembl=ENSBTAG00000025853|UniProtKB=Q2KJ56	Homer protein homolog 1	ISS	12653978	PubMed	PTHR10918:SF3	HOMER PROTEIN HOMOLOG 1
P00060	Ubiquitin proteasome pathway	P01491	E2	HUMAN|HGNC=12483|UniProtKB=P60604	Ubiquitin-conjugating enzyme E2 G2	ISS			PTHR24067:SF154	UBIQUITIN-CONJUGATING ENZYME E2 G2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00052	TGF-beta signaling pathway	P01281	SARA	HUMAN|HGNC=6775|UniProtKB=O95405	Zinc finger FYVE domain-containing protein 9	TAS	10733523	PubMed	PTHR22835:SF265	ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 9
P02775	Salvage pyrimidine ribonucleotides	P03149	Cytidine kinase	HUMAN|HGNC=15938|UniProtKB=Q9NWZ5	Uridine-cytidine kinase-like 1	ISS			PTHR10285:SF68	URIDINE-CYTIDINE KINASE-LIKE 1
P00059	p53 pathway	P04609	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	IC	10188796	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00010	B cell activation	P00372	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8235613	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	MOUSE|MGI=MGI=96433|UniProtKB=Q60751	Insulin-like growth factor 1 receptor	ISS	249616	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CANLF|Ensembl=ENSCAFG00000011689|UniProtKB=E2QZY2	Uncharacterized protein	ISS	11259498	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00005	Angiogenesis	P00193	SOS-1	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00057	Wnt signaling pathway	P01440	Cadherin	BOVIN|Ensembl=ENSBTAG00000005672|UniProtKB=F1N416	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF311	CADHERIN-22
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	CHICK|Ensembl=ENSGALG00000009320|UniProtKB=Q4JIM4	Presenilin-1	TAS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	PANTR|Ensembl=ENSPTRG00000022187|UniProtKB=Q7YQL4	Serine/threonine-protein kinase PAK 3	ISS	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CAEBR|Gene=CBG23091|UniProtKB=A8Y4Q9	Protein CBR-ACT-2	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	TAS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00008	Axon guidance mediated by Slit/Robo	P00355	Rho	MONDO|Ensembl=ENSMODG00000000981|UniProtKB=F7ES59	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00021	FGF signaling pathway	P00632	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00786	ARF	CANLF|Ensembl=ENSCAFG00000024150|UniProtKB=E2RHL4	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00047	PDGF signaling pathway	P01159	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00036	Interleukin signaling pathway	P00980	IRS1/2	HUMAN|HGNC=6125|UniProtKB=P35568	Insulin receptor substrate 1	IGI	15110093	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00193	SOS-1	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00049	Parkinson disease	P01211	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00624	14-3-3	BOVIN|Ensembl=ENSBTAG00000002108|UniProtKB=Q3SZI4	14-3-3 protein theta	ISS	10407019	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	PANTR|Ensembl=ENSPTRG00000012624|UniProtKB=H2QZG8	Uncharacterized protein	ISS	22028976	PubMed	PTHR13140:SF311	MYOSIN-IIIB
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00029	Huntington disease	P00796	Kainate receptor	MOUSE|MGI=MGI=95815|UniProtKB=P39087	Glutamate receptor ionotropic, kainate 2	IDA	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00034	Integrin signalling pathway	P00927	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00021	FGF signaling pathway	P00643	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	IDA	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00034	Integrin signalling pathway	P00924	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P02721	ATP synthesis	P02791	F1 alpha	TAKRU|Ensembl=ENSTRUG00000018034|UniProtKB=H2VAE8	ATP synthase subunit alpha	ISS	11479684	PubMed	PTHR43089:SF5	ATP SYNTHASE SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00056	VEGF signaling pathway	P01407	Erk	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00189	Fzd	CANLF|Ensembl=ENSCAFG00000008293|UniProtKB=E2R9M9	Uncharacterized protein	ISS	12549854	PubMed	PTHR11309:SF22	FRIZZLED-3
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01281	SARA	BOVIN|Ensembl=ENSBTAG00000014289|UniProtKB=F1MKY4	Uncharacterized protein	ISS	10733523	PubMed	PTHR22835:SF265	ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 9
P00047	PDGF signaling pathway	P01174	Rho	MACMU|Ensembl=ENSMMUG00000014953|UniProtKB=F6VTW2	Uncharacterized protein	ISS	8649427	PubMed	PTHR12552:SF5	RHO GTPASE-ACTIVATING PROTEIN 10
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	YEAST|SGD=S000005587|UniProtKB=P19454	Casein kinase II subunit alpha'	IDA	10806215	PubMed	PTHR24054:SF27	CASEIN KINASE II SUBUNIT ALPHA'
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95816|UniProtKB=B1AS29	Glutamate receptor ionotropic, kainate 3	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00019	Endothelin signaling pathway	P00589	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00034	Integrin signalling pathway	P00907	ERK	RAT|RGD=62087|UniProtKB=P27704	Mitogen-activated protein kinase 6	ISS	8444355	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P04393	Ras Pathway	P04556	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	3449797	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00056	VEGF signaling pathway	P01417	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00034	Integrin signalling pathway	P00907	ERK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS			PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06807	gnai	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	RCA	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00059	p53 pathway	G04694	p110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	3755548	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00896	Insulin IGF	MOUSE|MGI=MGI=96572|UniProtKB=P01325	Insulin-1	ISS			PTHR11454:SF24	INSULIN-1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00183	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	8264585	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=1951|UniProtKB=P08172	Muscarinic acetylcholine receptor M2	IDA	11166329	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	BOVIN|Ensembl=ENSBTAG00000037616|UniProtKB=F1MUD1	Uncharacterized protein	ISS	2433589	PubMed	PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P00015	Circadian clock system	G01497	cry	MACMU|Ensembl=ENSMMUG00000002453|UniProtKB=F7HH05	Cryptochrome-2	ISS	11804325	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	EMENI|EnsemblGenome=CADANIAG00004263|UniProtKB=Q8TFN0	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	TAKRU|Ensembl=ENSTRUG00000013411|UniProtKB=H2UB84	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00029	Huntington disease	P00774	Dynein complex	DICDI|dictyBase=DDB_G0276355|UniProtKB=P34036	Dynein heavy chain, cytoplasmic	IPI	9454836	PubMed	PTHR10676:SF314	CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00220	c-Jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	HUMAN|HGNC=4433|UniProtKB=P00505	Aspartate aminotransferase, mitochondrial	ISS			PTHR11879:SF32	ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL
P00057	Wnt signaling pathway	P01435	SWI/SNF	HUMAN|HGNC=11098|UniProtKB=P51531	Probable global transcription activator SNF2L2	IDA	11532957	PubMed	PTHR10799:SF541	GLOBAL TRANSCRIPTION ACTIVATOR SNF2L2-RELATED
P00029	Huntington disease	P00790	beta-Tubulin	ANOGA|EnsemblGenome=AGAP010929|UniProtKB=Q7PSI4	AGAP010929-PA	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	HUMAN|HGNC=6270|UniProtKB=Q92806	G protein-activated inward rectifier potassium channel 3	IDA			PTHR11767:SF17	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00557	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	11292874	PubMed	PTHR10048:SF14	PI-3 KINASE
P00011	Blood coagulation	P00418	Fibrin monomer	HUMAN|HGNC=3661|UniProtKB=P02671	Fibrinogen alpha chain	ISS	4503689	gi	PTHR19143:SF232	FIBRINOGEN ALPHA CHAIN
P00036	Interleukin signaling pathway	P00970	Interleukin	HUMAN|HGNC=6023|UniProtKB=P13232	Interleukin-7	IC	2643102	PubMed	PTHR45542:SF1	INTERLEUKIN-7
P00018	EGF receptor signaling pathway	P00547	PP2A	MOUSE|MGI=MGI=1321161|UniProtKB=P62715	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01021	Vglut	ORNAN|Ensembl=ENSOANG00000005584|UniProtKB=F6PYA3	Uncharacterized protein	ISS	12815758	PubMed	PTHR11662:SF207	VESICULAR GLUTAMATE TRANSPORTER 3
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00051	TCA cycle	P01267	Citrate Synthase	ECOLI|EcoGene=EG10402|UniProtKB=P0ABH7	Citrate synthase	ISS	11206551	PubMed	PTHR42871:SF1	CITRATE SYNTHASE
P00011	Blood coagulation	P00430	FX	MOUSE|MGI=MGI=103107|UniProtKB=O88947	Coagulation factor X	ISS	13278040	gi	PTHR44064:SF3	COAGULATION FACTOR X
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	TAS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	IC	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00057	Wnt signaling pathway	P01471	alpha-catenin	MONDO|Ensembl=ENSMODG00000012050|UniProtKB=F7ALE8	Uncharacterized protein	ISS	9362521	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00012	Cadherin signaling pathway	P00474	Wnt	DANRE|ZFIN=ZDB-GENE-990415-279|UniProtKB=P51029	Protein Wnt-8b	IDA	8717036	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00005	Angiogenesis	P00243	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00054	Toll receptor signaling pathway	P01364	TPL2	MOUSE|MGI=MGI=1346878|UniProtKB=Q07174	Mitogen-activated protein kinase kinase kinase 8	ISS	92019818	PubMed	PTHR24361:SF94	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 8
P04393	Ras Pathway	P04567	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02785	Valine biosynthesis	P03216	Acetolactate synthase	SULSO|EnsemblGenome=SSO2962|UniProtKB=Q97UP3	Acetolactate synthase large subunit homolog (IlvB-5)	ISS			PTHR42981:SF2	PYRUVATE DEHYDROGENASE  UBIQUINONE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CANLF|Ensembl=ENSCAFG00000015662|UniProtKB=E2RHY4	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00021	FGF signaling pathway	P00644	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00059	p53 pathway	P04630	PP2A	RAT|RGD=3380|UniProtKB=P63331	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00056	VEGF signaling pathway	P01403	VEGFR-2	MACMU|Ensembl=ENSMMUG00000012669|UniProtKB=F7E313	Uncharacterized protein	ISS	11221852	PubMed	PTHR24416:SF45	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=107469|UniProtKB=Q8K3R3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	10934033	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MONDO|Ensembl=ENSMODG00000001807|UniProtKB=F6Y7R9	Uncharacterized protein	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	XENTR|Xenbase=XB-GENE-491618|UniProtKB=Q6P378	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P02786	Vitamin B6 biosynthesis	P03225	1-Deoxyxylulose-5-phosphate synthase	THEMA|EnsemblGenome=TM_1770|UniProtKB=Q9X291	1-deoxy-D-xylulose-5-phosphate synthase	ISS			PTHR43322:SF5	1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE 1-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00012	Cadherin signaling pathway	P00470	F-actin	BOVIN|Ensembl=ENSBTAG00000014614|UniProtKB=P62739	Actin, aortic smooth muscle	ISS	3487386	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00047	PDGF signaling pathway	P01164	PDK1/2	ORYSJ|EnsemblGenome=OS01G0872800|UniProtKB=Q8RUE8	Os01g0872800 protein	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00010	B cell activation	P00381	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00011	Blood coagulation	P00406	Fibrinogen	MACMU|Ensembl=ENSMMUG00000021302|UniProtKB=F6UZ87	Uncharacterized protein	ISS	11761631	gi	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00049	Parkinson disease	P01227	20S proteasome	DANRE|ZFIN=ZDB-GENE-040618-2|UniProtKB=Q6DRF3	Proteasome subunit beta type	ISS	12859888	PubMed	PTHR11599:SF59	PROTEASOME SUBUNIT BETA TYPE-1
P00037	Ionotropic glutamate receptor pathway	P01006	NR2C	HUMAN|HGNC=4587|UniProtKB=Q14957	Glutamate receptor ionotropic, NMDA 2C	ISS	11319238	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00048	PI3 kinase pathway	P01182	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	TAS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00219	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00005	Angiogenesis	P00251	cPLA2	CANLF|Ensembl=ENSCAFG00000013778|UniProtKB=F6UQ33	Phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00018	EGF receptor signaling pathway	P00539	14-3-3	ARATH|TAIR=AT1G22300|UniProtKB=P48347	14-3-3-like protein GF14 epsilon	ISS	10407019	PubMed	PTHR18860:SF32	14-3-3 FAMILY PROTEIN-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	MOUSE|MGI=MGI=94924|UniProtKB=P61168	D(2) dopamine receptor	ISS	2137198	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00047	PDGF signaling pathway	P01160	IP3 receptor	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00005	Angiogenesis	P00181	SHP2	PANTR|Ensembl=ENSPTRG00000042397|UniProtKB=H2RIH8	Tyrosine-protein phosphatase non-receptor type	ISS	14525967	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04393	Ras Pathway	P04578	Rho	DAPPU|EnsemblGenome=DAPPUDRAFT_301996|UniProtKB=E9HL06	Putative uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01143	ERK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00053	T cell activation	P01336	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IC	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MOUSE|MGI=MGI=102522|UniProtKB=Q8R3Z5	Voltage-dependent L-type calcium channel subunit beta-1	IC	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00048	PI3 kinase pathway	P01187	IR	MOUSE|MGI=MGI=96575|UniProtKB=P15208	Insulin receptor	IDA	11182407	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00049	Parkinson disease	P01211	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	9836512	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00790	beta-Tubulin	ORYSJ|EnsemblGenome=OS05G0413200|UniProtKB=Q76FS3	Tubulin beta-6 chain	TAS	9454836	PubMed	PTHR11588:SF249	SUBFAMILY NOT NAMED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01087	CAT	MACMU|Ensembl=ENSMMUG00000004692|UniProtKB=F6RM01	Uncharacterized protein	ISS	92155737	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00035	Interferon-gamma signaling pathway	P00956	SOCS	PANTR|Ensembl=ENSPTRG00000040283|UniProtKB=H2RII6	Suppressor of cytokine signaling 5	ISS	22247722	PubMed	PTHR44282:SF3	SUPPRESSOR OF CYTOKINE SIGNALING 5
P00048	PI3 kinase pathway	P01188	Gbetagamma	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P02734	Chorismate biosynthesis	P02871	2-Deoxy-7-phosphoheptulonate synthase	YEAST|SGD=S000000453|UniProtKB=P32449	Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited	ISS			PTHR21225:SF0	PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, TYROSINE-INHIBITED
P04393	Ras Pathway	P04579	Shc	MOUSE|MGI=MGI=98296|UniProtKB=P98083	SHC-transforming protein 1	IDA	10982827	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00019	Endothelin signaling pathway	P00591	PLCbeta	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00047	PDGF signaling pathway	P01173	STAT	MOUSE|MGI=MGI=103034|UniProtKB=P52633	Signal transducer and transcription activator 6	ISS	12039028	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00053	T cell activation	P01331	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	11313908	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	DROME|FlyBase=FBgn0003205|UniProtKB=P08646	Ras-like protein 1	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00029	Huntington disease	P00790	beta-Tubulin	MOUSE|MGI=MGI=1920960|UniProtKB=Q9CWF2	Tubulin beta-2B chain	ISS	12932731	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	IC	91298951	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P02748	Isoleucine biosynthesis	P02994	Branched chain amino acid aminotransferase	CANLF|Ensembl=ENSCAFG00000011487|UniProtKB=F1PY28	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF51	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, CYTOSOLIC
P00052	TGF-beta signaling pathway	P01292	RSmads	MACMU|Ensembl=ENSMMUG00000018384|UniProtKB=F7GZL6	Mothers against decapentaplegic homolog	ISS	12736218	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04572	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00021	FGF signaling pathway	P00627	ERK1-2	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05915	Opioid proenkephalin pathway	P05993	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	ISS	11035810	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00010	B cell activation	P00402	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04558	p38	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	8920915	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	CAEBR|Gene=CBG_05938|UniProtKB=H8WGV2	Protein CBR-ITR-1, isoform a	ISS	1849282	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00052	TGF-beta signaling pathway	G01548	I-SMAD	MOUSE|MGI=MGI=1100518|UniProtKB=O35253	Mothers against decapentaplegic homolog 7	IGI	9335505	PubMed	PTHR13703:SF27	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 7
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02775	Salvage pyrimidine ribonucleotides	P03150	Uridine kinase	DEIRA|EnsemblGenome=DR_0159|UniProtKB=Q9RXZ5	Uridine kinase	ISS			PTHR10285:SF6	ATP-DEPENDENT KINASE TDA10-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	DANRE|ZFIN=ZDB-GENE-070112-342|UniProtKB=A1L271	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00045	Notch signaling pathway	P01113	Pen-2	RAT|RGD=621060|UniProtKB=O88777	Presenilin-2	IEP	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00877	MLCK	PANTR|Ensembl=ENSPTRG00000008081|UniProtKB=H2QB15	Uncharacterized protein	ISS	11157482	PubMed	PTHR45411:SF1	MYOSIN LIGHT CHAIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	HUMAN|HGNC=9508|UniProtKB=P49768	Presenilin-1	TAS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00029	Huntington disease	P00778	NMDA receptor	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00059	p53 pathway	P01485	p53	HUMAN|HGNC=11998|UniProtKB=P04637	Cellular tumor antigen p53	TAS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00010	B cell activation	P00383	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IDA	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00054	Toll receptor signaling pathway	P01352	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	CHICK|Ensembl=ENSGALG00000017238|UniProtKB=F1NWG3	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	CHICK|Ensembl=ENSGALG00000006426|UniProtKB=E1BS97	Uncharacterized protein	ISS	10644687	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00056	VEGF signaling pathway	P01423	p38MAPK	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	ISS	20451058	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	CANLF|Ensembl=ENSCAFG00000004882|UniProtKB=F1PAE3	Uncharacterized protein	ISS	14698990	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	BOVIN|Ensembl=ENSBTAG00000007964|UniProtKB=Q148J6	Actin-related protein 2/3 complex subunit 4	ISS	5031595	gi	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00035	Interferon-gamma signaling pathway	P00960	PTP	BOVIN|Ensembl=ENSBTAG00000002048|UniProtKB=F1N339	Tyrosine-protein phosphatase non-receptor type	ISS	95163101	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00009	Axon guidance mediated by netrin	P00364	cdc42	HUMAN|HGNC=1736|UniProtKB=P60953	Cell division control protein 42 homolog	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	HUMAN|HGNC=1960|UniProtKB=P36544	Neuronal acetylcholine receptor subunit alpha-7	ISS	11404397	PubMed	PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	12086862	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00975	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	ORNAN|Ensembl=ENSOANG00000011750|UniProtKB=F6TWB9	Nucleoside diphosphate kinase	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P05915	Opioid proenkephalin pathway	P05994	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00048	PI3 kinase pathway	P01177	P110ACT	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00059	p53 pathway	G04694	p110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000002658|UniProtKB=F7CB14	Uncharacterized protein	ISS	2137198	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00034	Integrin signalling pathway	P00927	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00010	B cell activation	P00384	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	188830	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MOUSE|MGI=MGI=1351343|UniProtKB=Q5NCH9	Metabotropic glutamate receptor 6	ISS			PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P05918	p38 MAPK pathway	P06016	HSP27	HUMAN|HGNC=5246|UniProtKB=P04792	Heat shock protein beta-1	IDA	8280084	PubMed	PTHR11527:SF114	HEAT SHOCK PROTEIN BETA-1
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CAEEL|WormBase=WBGene00009478|UniProtKB=O62236	SYntaXin	IC	14570579	PubMed	PTHR19957:SF209	LD23667P
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01437	TCF	XENTR|Xenbase=XB-GENE-1031985|UniProtKB=Q6GL68	Transcription factor 7-like 1	ISS	11266476	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04393	Ras Pathway	P04559	Rac	ORYSJ|EnsemblGenome=OS02G0834000|UniProtKB=Q6EP31	Rac-like GTP-binding protein 5	ISS	10860831	PubMed	PTHR24072:SF194	RAC-LIKE GTP-BINDING PROTEIN ARAC4-RELATED
P00059	p53 pathway	P01480	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00036	Interleukin signaling pathway	P00964	p90RSK	MONDO|Ensembl=ENSMODG00000008086|UniProtKB=F6YJ34	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00006	Apoptosis signaling pathway	P00274	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	MACMU|Ensembl=ENSMMUG00000020622|UniProtKB=F7BMA6	DNA-directed RNA polymerases I, II, and III subunit RPABC5	ISS			PTHR23431:SF3	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5
P00005	Angiogenesis	P00223	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MONDO|Ensembl=ENSMODG00000000771|UniProtKB=F6SSS3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT1G59580|UniProtKB=Q39022	Mitogen-activated protein kinase 2	ISS	94177172	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05938	RhoA	DANRE|ZFIN=ZDB-GENE-040718-144|UniProtKB=Q6DHE8	Rho-related GTP-binding protein RhoA-D	ISS	12024019	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MOUSE|MGI=MGI=2150393|UniProtKB=Q91ZU9	Glutamate receptor ionotropic, NMDA 3B	ISS	11319238	PubMed	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01043	AC	DICDI|dictyBase=DDB_G0276269|UniProtKB=Q551V8	Guanylyl cyclase	IC	9874775	PubMed	PTHR43642:SF2	GUANYLYL CYCLASE
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01182	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00036	Interleukin signaling pathway	P00983	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00777	CBP	ARATH|TAIR=AT1G55970|UniProtKB=Q9LG11	Histone acetyltransferase HAC4	IDA	10823891	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00010	B cell activation	P00391	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P06664	Gonadotropin-releasing hormone receptor pathway	P06812	L-type Ca2+	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	RCA	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01159	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05915	Opioid proenkephalin pathway	P05985	Mu or Delta receptor	MOUSE|MGI=MGI=97438|UniProtKB=P32300	Delta-type opioid receptor	RCA	12093103	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P02779	Thiamin biosynthesis	P03175	1-Deoxyxylulose-5-phosphate synthase	CHLRE|EnsemblGenome=CHLREDRAFT_196568|UniProtKB=A8JFW4	1-deoxy-D-xylulose 5-phosphate synthase (Fragment)	ISS			PTHR43322:SF5	1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE 1-RELATED
P00057	Wnt signaling pathway	P01451	Galpha	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	IDA	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	1718748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02773	S-adenosylmethionine biosynthesis	P03142	Cobalamin-dependent homocysteine transmethylase	PANTR|Ensembl=ENSPTRG00000002145|UniProtKB=H2R7Z7	5-methyltetrahydrofolate-homocysteine methyltransferase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CHICK|Ensembl=ENSGALG00000011086|UniProtKB=P68139	Actin, alpha skeletal muscle	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00059	p53 pathway	P01486	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04407	K+ channel	MOUSE|MGI=MGI=1100509|UniProtKB=O35111	Potassium channel subfamily K member 3	ISS	11875121	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P04393	Ras Pathway	P04556	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00057	Wnt signaling pathway	P01458	Protein Kinase C	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	IDA	2837282	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00006	Apoptosis signaling pathway	P00297	NFkappaB	MOUSE|MGI=MGI=97897|UniProtKB=P15307	Proto-oncogene c-Rel	IDA	11884420	PubMed	PTHR24169:SF4	PROTO-ONCOGENE C-REL
P00015	Circadian clock system	P00501	Clock	BOVIN|Ensembl=ENSBTAG00000044044|UniProtKB=F1MLT7	Uncharacterized protein	ISS	8171325	PubMed	PTHR23042:SF2	CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01284	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	CANLF|Ensembl=ENSCAFG00000028654|UniProtKB=J9P702	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00004	Alzheimer disease-presenilin pathway	P00128	Erb-B4	MACMU|Ensembl=ENSMMUG00000001674|UniProtKB=F7G3H1	Receptor protein-tyrosine kinase	ISS	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P04375	5HT3 type receptor mediated signaling pathway	P04422	5HT3 Rec	HUMAN|HGNC=5298|UniProtKB=O95264	5-hydroxytryptamine receptor 3B	IC	7509203	PubMed	PTHR18945:SF53	5-HYDROXYTRYPTAMINE RECEPTOR 3B
P00054	Toll receptor signaling pathway	P01367	MKK3	ORNAN|Ensembl=ENSOANG00000007732|UniProtKB=F6PXH5	Uncharacterized protein (Fragment)	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00021	FGF signaling pathway	P00648	PKC	NEUCR|EnsemblGenome=EFNCRG00000006341|UniProtKB=P87253	Protein kinase C-like	ISS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00009	Axon guidance mediated by netrin	P00364	cdc42	ANOGA|EnsemblGenome=AGAP002440|UniProtKB=Q17031	Cdc42 homolog	ISS	4757952	gi	PTHR24072:SF192	CDC42 HOMOLOG
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00059	p53 pathway	G04694	p110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P02734	Chorismate biosynthesis	P02871	2-Deoxy-7-phosphoheptulonate synthase	DEIRA|EnsemblGenome=DR_1817|UniProtKB=Q9RTE8	Phospho-2-dehydro-3-deoxyheptonate aldolase	ISS			PTHR21225:SF12	PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, PHE-SENSITIVE
P00005	Angiogenesis	P00251	cPLA2	RAT|RGD=67366|UniProtKB=P50393	Cytosolic phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MOUSE|MGI=MGI=2152453|UniProtKB=Q2NL51	Glycogen synthase kinase-3 alpha	ISS	2164470	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P02751	Lysine biosynthesis	P03013	Aspartate semialdehyde dehydrogenase	ARATH|TAIR=AT1G14820|UniProtKB=B9DGS8	AT1G14820 protein	ISS			PTHR10174:SF121	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8972|UniProtKB=O00750	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MOUSE|MGI=MGI=1346875|UniProtKB=O08648	Mitogen-activated protein kinase kinase kinase 4	IGI	9079650	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00052	TGF-beta signaling pathway	P01286	TGFbeta	PANTR|Ensembl=ENSPTRG00000017705|UniProtKB=H2QS99	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF137	BONE MORPHOGENETIC PROTEIN 6
P00034	Integrin signalling pathway	P00917	ELMO	MACMU|Ensembl=ENSMMUG00000023104|UniProtKB=F7DM33	Engulfment and cell motility protein 1 isoform 1	ISS	12879077	PubMed	PTHR12771:SF23	ENGULFMENT AND CELL MOTILITY PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	STRCO|Gene=CAB77289|UniProtKB=Q9L0U6	Putative proton transport protein	ISS			PTHR42865:SF10	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00648	PKC	SCHPO|PomBase=SPBC12D12.04c|UniProtKB=P36583	Protein kinase C-like 2	IGI	8491190	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P02726	Aminobutyrate degradation	P02824	Succinate semi-aldehyde dehydrogenase	METAC|EnsemblGenome=MA_0705|UniProtKB=Q8TSU0	Aldehyde dehydrogenase	ISS			PTHR43217:SF1	SUCCINATE SEMIALDEHYDE DEHYDROGENASE  NAD P +  SAD
P05916	Opioid prodynorphin pathway	P06002	G-protein	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	ARATH|TAIR=AT4G31990|UniProtKB=P46248	Aspartate aminotransferase, chloroplastic	ISS			PTHR11879:SF1	ASPARTATE AMINOTRANSFERASE, CYTOPLASMIC
P00021	FGF signaling pathway	P00646	RasGAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P05731	GABA-B receptor II signaling	P05760	AC	MOUSE|MGI=MGI=108450|UniProtKB=P51830	Adenylate cyclase type 9	RCA	2491850	PubMed	PTHR11920:SF319	ADENYLATE CYCLASE TYPE 9
P04398	p53 pathway feedback loops 2	P04657	P110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MONDO|Ensembl=ENSMODG00000012009|UniProtKB=F7AMI2	Uncharacterized protein	ISS	12562507	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00054	Toll receptor signaling pathway	P01339	TLR4	MOUSE|MGI=MGI=96824|UniProtKB=Q9QUK6	Toll-like receptor 4	ISS			PTHR44568:SF1	TOLL-LIKE RECEPTOR 4
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	PSEAE|EnsemblGenome=PA0887|UniProtKB=Q9I558	Acetyl-coenzyme A synthetase 1	ISS			PTHR24095:SF243	ACETYL-COENZYME A SYNTHETASE
P04397	p53 pathway by glucose deprivation	P04636	S6K	PANTR|Ensembl=ENSPTRG00000009477|UniProtKB=H2QDK7	Ribosomal protein S6 kinase	ISS	11861821	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00030	Hypoxia response via HIF activation	P00814	P300	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00019	Endothelin signaling pathway	P00581	Guanylate cyclase	HUMAN|HGNC=4685|UniProtKB=Q02108	Guanylate cyclase soluble subunit alpha-3	RCA			PTHR11920:SF226	GUANYLATE CYCLASE SOLUBLE SUBUNIT ALPHA-3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00059	p53 pathway	P01486	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00046	Oxidative stress response	P01125	Stat1	HUMAN|HGNC=11362|UniProtKB=P42224	Signal transducer and activator of transcription 1-alpha/beta	TAS	15825084	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00006	Apoptosis signaling pathway	P00313	IKK	MACMU|Ensembl=ENSMMUG00000008351|UniProtKB=F7HRV5	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00037	Ionotropic glutamate receptor pathway	P01018	Glu1	PANTR|Ensembl=ENSPTRG00000017441|UniProtKB=H2QRU7	Glutamate receptor, ionotropic, AMPA 1	ISS	12941441	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00046	Oxidative stress response	P01135	p38	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	TAS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	CHICK|Gene=CHRM3|UniProtKB=P49578	Muscarinic acetylcholine receptor M3	TAS	12915051	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00034	Integrin signalling pathway	P00920	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04393	Ras Pathway	P04560	AP1	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	DEIRA|EnsemblGenome=DR_2632|UniProtKB=Q9RR65	Dihydrofolate reductase	ISS			PTHR22778:SF16	DIHYDROFOLATE REDUCTASE
P00019	Endothelin signaling pathway	P00570	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00269	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	TAS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00060	Ubiquitin proteasome pathway	P01490	E3	MACMU|Ensembl=ENSMMUG00000012912|UniProtKB=F6S0K0	Uncharacterized protein	ISS			PTHR11254:SF66	E3 UBIQUITIN-PROTEIN LIGASE ITCHY HOMOLOG
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00705	Gsalpha	CHICK|Ensembl=ENSGALG00000013785|UniProtKB=E1BS74	Uncharacterized protein	ISS	2106672	PubMed	PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00049	Parkinson disease	P01217	beta-Synuclein	BOVIN|Gene=SNCB|UniProtKB=P33567	Beta-synuclein	IDA	11683992	PubMed	PTHR13820:SF4	BETA-SYNUCLEIN
P00029	Huntington disease	P00796	Kainate receptor	CANLF|Ensembl=ENSCAFG00000003333|UniProtKB=F1PWT6	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00021	FGF signaling pathway	P00627	ERK1-2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	NEUCR|EnsemblGenome=EFNCRG00000003813|UniProtKB=Q1K7I3	Extracellular developmental signal biosynthesis protein FluG	ISS			PTHR43785:SF2	TYPE-1 GLUTAMINE SYNTHETASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=94926|UniProtKB=P51436	D(4) dopamine receptor	IDA	11861492	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00029	Huntington disease	P00790	beta-Tubulin	CHICK|Ensembl=ENSGALG00000000059|UniProtKB=F1NMU4	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	METAC|EnsemblGenome=MA_0278|UniProtKB=Q8TTZ7	TATA-box-binding protein 3	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	15572354	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00049	Parkinson disease	P01208	Hsp70	CANAL|CGD=CAL0000184706|UniProtKB=P41797	Heat shock protein SSA1	IDA	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00057	Wnt signaling pathway	P01438	PP2A	MOUSE|MGI=MGI=1321161|UniProtKB=P62715	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P02742	Tetrahydrofolate biosynthesis	P02945	Dihydropteroate synthase	CHLTR|EnsemblGenome=CT_613|UniProtKB=O84619	Folate synthesis bifunctional protein	ISS			PTHR20941:SF1	FOLIC ACID SYNTHESIS PROTEIN FOL1
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00922	Collagen	MOUSE|MGI=MGI=88463|UniProtKB=Q00780	Collagen alpha-1(VIII) chain	IDA	10778855	PubMed	PTHR44057:SF2	COLLAGEN ALPHA-1 VIII  CHAIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	TAS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00636	FGFR1-4	CANLF|Ensembl=ENSCAFG00000014993|UniProtKB=F1P9Z7	Fibroblast growth factor receptor	ISS	94209351	PubMed	PTHR24416:SF505	FIBROBLAST GROWTH FACTOR RECEPTOR 3
P00005	Angiogenesis	P00248	Ang-1	HUMAN|HGNC=484|UniProtKB=Q15389	Angiopoietin-1	IGI	8980223	PubMed	PTHR19143:SF156	ANGIOPOIETIN-1
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	ANOGA|Gene=AgaP_AGAP009443|UniProtKB=Q5TXC3	AGAP009443-PA (Fragment)	ISS	94365697	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P04398	p53 pathway feedback loops 2	P04661	PI3K	XENTR|Xenbase=XB-GENE-6067221|UniProtKB=F6Z0J4	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00023	General transcription regulation	P00660	RNA Polymerase II	NEUCR|EnsemblGenome=EFNCRG00000008291|UniProtKB=Q7SAL1	UDP-glucose 4-epimerase Gal10	ISS	606023	OMIM	PTHR10917:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00047	PDGF signaling pathway	P01174	Rho	MONDO|Ensembl=ENSMODG00000017613|UniProtKB=F7AH39	Uncharacterized protein (Fragment)	ISS			PTHR15377:SF4	RHO GTPASE-ACTIVATING PROTEIN 5
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IGI	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05731	GABA-B receptor II signaling	P05760	AC	PANTR|Ensembl=ENSPTRG00000019161|UniProtKB=H2QUJ4	Uncharacterized protein	ISS	89298382	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	11832947	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00057	Wnt signaling pathway	P01444	Wnt	MACMU|Ensembl=ENSMMUG00000017345|UniProtKB=F7H9C0	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00018	EGF receptor signaling pathway	P00558	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IGI	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00017	DNA replication	P00527	Histones	IXOSC|EnsemblGenome=ISCW003178|UniProtKB=B7PAJ2	Histone H3	ISS	20448842	PubMed	PTHR11426:SF169	HISTONE H3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	RCA			PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	CAEEL|WormBase=WBGene00006390|UniProtKB=Q7YTH5	TAF (TBP-associated transcription factor) family	ISS	604904	OMIM	PTHR12321:SF78	TAF  TBP-ASSOCIATED TRANSCRIPTION FACTOR  FAMILY
P00021	FGF signaling pathway	P00636	FGFR1-4	XENTR|Xenbase=XB-GENE-478699|UniProtKB=F6VYS9	Fibroblast growth factor receptor	ISS			PTHR24416:SF343	FIBROBLAST GROWTH FACTOR RECEPTOR 4
P00038	JAK/STAT signaling pathway	P01027	STAT	PANTR|Ensembl=ENSPTRG00000009199|UniProtKB=H2QD19	Signal transducer and activator of transcription	ISS	95188889	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00048	PI3 kinase pathway	P01182	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	14744463	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00010	B cell activation	P00402	Jnk	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CANLF|Ensembl=ENSCAFG00000015708|UniProtKB=F2Z4N0	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00060	Ubiquitin proteasome pathway	P01491	E2	SCHPO|PomBase=SPBC211.07c|UniProtKB=Q9P7R4	Ubiquitin-conjugating enzyme E2 8	ISS			PTHR43946:SF2	UBIQUITIN-CONJUGATING ENZYME E2 H
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	STRPU|EnsemblGenome=SPU_018419|UniProtKB=W4YRI6	Uncharacterized protein	ISS	97210759	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	ORYSJ|EnsemblGenome=OS03G0285800|UniProtKB=Q10N20	Mitogen-activated protein kinase 5	ISS			PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	10747026	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	CAEEL|WormBase=WBGene00013709|UniProtKB=Q8WQ99	Casein kinase I gamma	IDA	10617630	PubMed	PTHR11909:SF155	GILGAMESH, ISOFORM L
P00005	Angiogenesis	P00256	PLC-gamma	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000003399|UniProtKB=H2Q383	Phosphoinositide-3-kinase, class 2, alpha polypeptide	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P02721	ATP synthesis	P02791	F1 alpha	ORNAN|Ensembl=ENSOANG00000014907|UniProtKB=F6V9Q4	ATP synthase subunit alpha (Fragment)	ISS	2527557	PubMed	PTHR43089:SF5	ATP SYNTHASE SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01465	Ggamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05916	Opioid prodynorphin pathway	P06002	G-protein	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P05915	Opioid proenkephalin pathway	P05994	G-protein	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF31	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04651	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	91232861	PubMed	PTHR24070:SF385	GTPASE HRAS
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00047	PDGF signaling pathway	P01168	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	7565716	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05917	Opioid proopiomelanocortin pathway	P06011	AC	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	ISS	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00021	FGF signaling pathway	P00637	MKK4,7	DROME|FlyBase=FBgn0010303|UniProtKB=Q23977	Dual specificity mitogen-activated protein kinase kinase hemipterous	RCA			PTHR24361:SF387	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TRIVA|Gene=TVAG_337240|UniProtKB=P90623	Actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00025	Hedgehog signaling pathway	P00691	CBP	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00057	Wnt signaling pathway	P01432	Beta-Catenin	MONDO|Ensembl=ENSMODG00000011192|UniProtKB=F6SRK5	Uncharacterized protein	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	RCA	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	CHICK|Ensembl=ENSGALG00000006197|UniProtKB=P21868	Casein kinase II subunit alpha	IDA	10806215	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	NEUCR|EnsemblGenome=EFNCRG00000003892|UniProtKB=Q9UUY8	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00037	Ionotropic glutamate receptor pathway	P01018	Glu1	MACMU|Ensembl=ENSMMUG00000009287|UniProtKB=F7H3T9	Glutamate receptor 1 isoform 1	ISS	12941441	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00005	Angiogenesis	P00219	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02928	Dihydroorotase	METAC|EnsemblGenome=MA_0892|UniProtKB=Q8TSA6	Dihydroorotase	ISS			PTHR43668:SF2	ALLANTOINASE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00034	Integrin signalling pathway	P00906	Rap1	BOVIN|Ensembl=ENSBTAG00000008967|UniProtKB=P61223	Ras-related protein Rap-1b	ISS	1904317	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00006	Apoptosis signaling pathway	P00318	PKCs	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00050	Plasminogen activating cascade	P01244	PAI-2	MACMU|Ensembl=ENSMMUG00000016617|UniProtKB=F6TWU5	Uncharacterized protein	ISS	4505595	gi	PTHR11461:SF61	PLASMINOGEN ACTIVATOR INHIBITOR 2
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MACMU|Ensembl=ENSMMUG00000016675|UniProtKB=F6VTB5	Uncharacterized protein	ISS	11319238	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00053	T cell activation	P01312	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000004742|UniProtKB=H2Q5K1	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P00046	Oxidative stress response	P01135	p38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04393	Ras Pathway	P04561	SRF	MONDO|Ensembl=ENSMODG00000018981|UniProtKB=F7FP88	Uncharacterized protein	ISS	8660892	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00019	Endothelin signaling pathway	P00587	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	DANRE|Ensembl=ENSDARG00000070511|UniProtKB=E7F5R2	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF282	GLUTAMATE RECEPTOR-RELATED
P00046	Oxidative stress response	P01129	JNK1/2	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00059	p53 pathway	P01486	Akt	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	TAS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00045	Notch signaling pathway	P01104	Serrate	MONDO|Ensembl=ENSMODG00000004910|UniProtKB=F7C1Q4	Delta-like protein	ISS	8955070	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00012	Cadherin signaling pathway	P00470	F-actin	BOVIN|Ensembl=ENSBTAG00000014614|UniProtKB=P62739	Actin, aortic smooth muscle	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000004896|UniProtKB=F7C2C6	Uncharacterized protein (Fragment)	ISS	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P02747	Histidine biosynthesis	P02991	Histidinephosphate aminotransferase	ORYSJ|EnsemblGenome=OS02G0709200|UniProtKB=Q0DY86	Os02g0709200 protein	ISS			PTHR42885:SF2	HISTIDINOL-PHOSPHATE AMINOTRANSFERASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IC	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	176892	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01428	Frizzled	PANTR|Ensembl=ENSPTRG00000020122|UniProtKB=H2QVZ0	Uncharacterized protein	ISS	12549854	PubMed	PTHR11309:SF22	FRIZZLED-3
P00021	FGF signaling pathway	P00636	FGFR1-4	ORNAN|Ensembl=ENSOANG00000003252|UniProtKB=F6SM70	Fibroblast growth factor receptor	ISS	1708247	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	FUSNN|EnsemblGenome=FN0488|UniProtKB=Q8RG30	Glutamate dehydrogenase	ISS			PTHR11606:SF13	GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00053	T cell activation	P01311	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	CHICK|Ensembl=ENSGALG00000000681|UniProtKB=E1C3P6	Uncharacterized protein	ISS	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00004	Alzheimer disease-presenilin pathway	P00118	E-cadherin	PANTR|Ensembl=ENSPTRG00000008269|UniProtKB=H2QBE4	Cadherin 3, type 1, P-cadherin (Placental)	ISS	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P00018	EGF receptor signaling pathway	P00548	RKIP	ORYSJ|EnsemblGenome=OS06G0157700|UniProtKB=Q93WI9	Protein HEADING DATE 3A	ISS			PTHR11362:SF9	PROTEIN FLOWERING LOCUS T-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05959	FLNA	HUMAN|HGNC=3754|UniProtKB=P21333	Filamin-A	IPI	9722563	PubMed	PTHR43998:SF6	FILAMIN-A
P00013	Cell cycle	P00480	Proteasome	HUMAN|HGNC=9558|UniProtKB=Q9UNM6	26S proteasome non-ATPase regulatory subunit 13	ISS	99239941	PubMed	PTHR10539:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95814|UniProtKB=Q60934	Glutamate receptor ionotropic, kainate 1	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	DICPU|Gene=DICPUDRAFT_93216|UniProtKB=F1A421	Guanine nucleotide-binding protein subunit beta	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00029	Huntington disease	P00790	beta-Tubulin	TAKRU|Ensembl=ENSTRUG00000005300|UniProtKB=H2SJZ5	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P05918	p38 MAPK pathway	P06043	ASK1	PANTR|Ensembl=ENSPTRG00000024326|UniProtKB=H2R231	Uncharacterized protein	ISS	12566458	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00036	Interleukin signaling pathway	P00975	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00022	General transcription by RNA polymerase I	P00651	TAF-IA	HUMAN|HGNC=11532|UniProtKB=Q15573	TATA box-binding protein-associated factor RNA polymerase I subunit A	IGI	600075	OMIM	PTHR32122:SF1	TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT A
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	EMENI|EnsemblGenome=CADANIAG00006296|UniProtKB=Q5ASG1	Putative synaptobrevin homologue SNC1/2 (Eurofung)	ISS			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00047	PDGF signaling pathway	P01153	GSK3	ARATH|TAIR=AT4G18710|UniProtKB=Q39011	Shaggy-related protein kinase eta	ISS	12615961	PubMed	PTHR24057:SF5	SHAGGY-RELATED PROTEIN KINASE ETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	DANRE|ZFIN=ZDB-GENE-040120-7|UniProtKB=Q7ZWH4	Actin-related protein 2/3 complex subunit 5	ISS	12473693	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P02738	De novo purine biosynthesis	P02907	dADP kinase	MOUSE|MGI=MGI=2150309|UniProtKB=Q4VA61	Down syndrome cell adhesion molecule-like protein 1 homolog	ISS			PTHR44107:SF3	DOWN SYNDROME CELL ADHESION MOLECULE-LIKE PROTEIN 1
P02728	Arginine biosynthesis	P02846	Ornithine carbamoyl transferase	YEAST|SGD=S000003624|UniProtKB=P05150	Ornithine carbamoyltransferase	ISS			PTHR11405:SF1	ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05730	Endogenous cannabinoid signaling	P05746	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	ORYSJ|EnsemblGenome=OS07G0495100|UniProtKB=Q84RS4	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00029	Huntington disease	P00775	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	DROME|FlyBase=FBgn0004921|UniProtKB=P38040	Guanine nucleotide-binding protein subunit gamma-1	IDA			PTHR13809:SF3	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MOUSE|MGI=MGI=1928375|UniProtKB=Q9JM76	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00046	Oxidative stress response	P01126	ATF2	MOUSE|MGI=MGI=109349|UniProtKB=P16951	Cyclic AMP-dependent transcription factor ATF-2	TAS	10207617	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	IC	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00029	Huntington disease	P00780	Microtubule	BOVIN|Ensembl=ENSBTAG00000021013|UniProtKB=Q3ZBU7	Tubulin beta-4A chain	ISS	9454836	PubMed	PTHR11588:SF253	TUBULIN BETA-4A CHAIN
P04398	p53 pathway feedback loops 2	P04651	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	BOVIN|Ensembl=ENSBTAG00000008151|UniProtKB=F1MH06	Uncharacterized protein	ISS	8649450	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00010	B cell activation	P00371	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05970	TH	MACMU|Ensembl=ENSMMUG00000003912|UniProtKB=F6ZV38	Uncharacterized protein	ISS	191290	OMIM	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=619760|UniProtKB=P58365	Cadherin-23	IDA	8120095	PubMed	PTHR43956:SF3	CADHERIN-23
P04393	Ras Pathway	P04569	Cdc42	ANOGA|EnsemblGenome=AGAP002440|UniProtKB=Q17031	Cdc42 homolog	ISS	4757952	gi	PTHR24072:SF192	CDC42 HOMOLOG
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DANRE|ZFIN=ZDB-GENE-040426-2555|UniProtKB=F8W3G9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MONDO|Ensembl=ENSMODG00000005623|UniProtKB=F7CFG8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00005	Angiogenesis	P00256	PLC-gamma	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00054	Toll receptor signaling pathway	P01355	AP1	XENTR|Xenbase=XB-GENE-482228|UniProtKB=F6RYL1	Uncharacterized protein	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MACMU|Ensembl=ENSMMUG00000004253|UniProtKB=F6YQ28	Uncharacterized protein	ISS	8207000	PubMed	PTHR10201:SF165	COLLAGENASE 3
P00049	Parkinson disease	P01227	20S proteasome	MACMU|Ensembl=ENSMMUG00000022451|UniProtKB=F7AC21	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF16	PROTEASOME SUBUNIT ALPHA TYPE-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DROME|FlyBase=FBgn0261854|UniProtKB=A1Z9X0	Atypical protein kinase C	ISS	2837282	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	RCA	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00036	Interleukin signaling pathway	P00990	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	MOUSE|MGI=MGI=101863|UniProtKB=P05063	Fructose-bisphosphate aldolase C	ISS	2350361	PubMed	PTHR11627:SF3	FRUCTOSE-BISPHOSPHATE ALDOLASE C
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01160	IP3 receptor	ANOGA|EnsemblGenome=AGAP006475|UniProtKB=Q5TQX0	AGAP006475-PA	ISS	11007872	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00005	Angiogenesis	P00251	cPLA2	MACMU|Ensembl=ENSMMUG00000003848|UniProtKB=F7HAE1	Phospholipase A2	ISS			PTHR10728:SF31	CYTOSOLIC PHOSPHOLIPASE A2 DELTA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00053	T cell activation	P01305	Calmodulin	HUMAN|HGNC=1442|UniProtKB=P62158	Calmodulin	IDA	9753452	PubMed	PTHR23050:SF311	CALMODULIN
P00012	Cadherin signaling pathway	P00468	Src	BOVIN|Ensembl=ENSBTAG00000008938|UniProtKB=E1BIM8	Tyrosine-protein kinase	ISS	8054685	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00029	Huntington disease	G01535	PIG3	CANLF|Ensembl=ENSCAFG00000020034|UniProtKB=E2RQB8	Uncharacterized protein	ISS	12932731	PubMed	PTHR44054:SF2	SYNAPTIC VESICLE MEMBRANE PROTEIN VAT-1 HOMOLOG-LIKE
P00056	VEGF signaling pathway	P01422	eNOS	CANLF|Gene=NOS3|UniProtKB=Q9TUX8	Nitric oxide synthase, endothelial	ISS	10435050	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00045	Notch signaling pathway	P01114	Ntm	MACMU|Ensembl=ENSMMUG00000017022|UniProtKB=F7HQZ9	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00019	Endothelin signaling pathway	P00566	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00048	PI3 kinase pathway	P01192	p110	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	HUMAN|HGNC=5465|UniProtKB=P08069	Insulin-like growth factor 1 receptor	ISS	6754360	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P04398	p53 pathway feedback loops 2	P04657	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00046	Oxidative stress response	P01135	p38	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	TAS	8925912	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	ORNAN|Ensembl=ENSOANG00000003489|UniProtKB=F7FSE3	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00047	PDGF signaling pathway	P01140	ELK	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	ISS	11050086	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00021	FGF signaling pathway	P00644	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	ISS	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P06664	Gonadotropin-releasing hormone receptor pathway	P06834	MAP3Ks	MOUSE|MGI=MGI=2444243|UniProtKB=Q1HKZ5	Mitogen-activated protein kinase kinase kinase 13	RCA			PTHR44359:SF2	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 13
P00005	Angiogenesis	P00207	Crk	DROME|FlyBase=FBgn0024811|UniProtKB=Q9XYM0	Adapter molecule Crk	ISS			PTHR19969:SF5	ADAPTER MOLECULE CRK
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	BOVIN|Ensembl=ENSBTAG00000001067|UniProtKB=E1BAB4	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P04616	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	DEIRA|EnsemblGenome=DR_B0109|UniProtKB=Q9RZL6	Ribonucleoside-diphosphate reductase, beta chain	ISS			PTHR23409:SF32	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00046	Oxidative stress response	P01127	eEF2K	PANTR|Ensembl=ENSPTRG00000007877|UniProtKB=H2QAR0	Eukaryotic elongation factor-2 kinase	ISS	11500363	PubMed	PTHR14187:SF56	EUKARYOTIC ELONGATION FACTOR 2 KINASE
P02738	De novo purine biosynthesis	P02904	Guanylate kinase	FUSNN|EnsemblGenome=FN2033|UniProtKB=Q8RHI9	Guanylate kinase	ISS			PTHR23117:SF13	GUANYLATE KINASE
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	MOUSE|MGI=MGI=3584516|UniProtKB=E9Q1T6	Protein Lrp3	ISS	11907044	PubMed	PTHR44062:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 3
P00018	EGF receptor signaling pathway	P00551	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00947	Laminin	PANTR|Ensembl=ENSPTRG00000019588|UniProtKB=H2QV85	Uncharacterized protein	ISS	2538453	PubMed	PTHR10574:SF279	LAMININ SUBUNIT BETA-4
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00021	FGF signaling pathway	P00639	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	7680960	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	TRIAD|EnsemblGenome=TriadG63686|UniProtKB=B3RQ31	Beta-tubulin	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00053	T cell activation	P01300	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	YEAST|SGD=S000000028|UniProtKB=P31109	Synaptobrevin homolog 1	ISS			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P04398	p53 pathway feedback loops 2	P04668	p53	CANLF|Ensembl=ENSCAFG00000013961|UniProtKB=F1PL57	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=1351339|UniProtKB=Q14BI2	Metabotropic glutamate receptor 2	ISS	12351712	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00057	Wnt signaling pathway	P01438	PP2A	MONDO|Ensembl=ENSMODG00000019007|UniProtKB=F7C5Z9	Uncharacterized protein	ISS	96161994	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00021	FGF signaling pathway	P00644	p38	CAEEL|WormBase=WBGene00004055|UniProtKB=Q17446	Mitogen-activated protein kinase pmk-1	IGI	11274345	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02724	Alanine biosynthesis	P02815	Branched chain amino acid aminotransferase	DROME|FlyBase=FBgn0030482|UniProtKB=Q9VYD5	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF44	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P00018	EGF receptor signaling pathway	P00539	14-3-3	CAEBR|Gene=CBG17289|UniProtKB=A8XQR9	14-3-3 zeta	ISS	10407019	PubMed	PTHR18860:SF13	14-3-3 PROTEIN ZETA
P02740	De novo pyrimidine ribonucleotides biosythesis	P02926	Aspartate carbamoyltransferase	PSEAE|EnsemblGenome=PA0402|UniProtKB=Q59653	Aspartate carbamoyltransferase	ISS			PTHR11405:SF16	ASPARTATE CARBAMOYLTRANSFERASE, CHLOROPLASTIC
P00006	Apoptosis signaling pathway	P00318	PKCs	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P02736	Coenzyme A biosynthesis	P02886	Pantetheine-phosphate adenyltransferase	LEPIN|EnsemblGenome=LA_4167|UniProtKB=Q8EYP6	Phosphopantetheine adenylyltransferase	ISS			PTHR21342:SF1	PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE
P00005	Angiogenesis	P00256	PLC-gamma	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	MONDO|Ensembl=ENSMODG00000014763|UniProtKB=F7GGT3	Uncharacterized protein	ISS			PTHR23409:SF20	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00021	FGF signaling pathway	P00648	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04398	p53 pathway feedback loops 2	G04714	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IC	22040490	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P04392	P53 pathway feedback loops 1	G04684	Pirh-2	MOUSE|MGI=MGI=1915348|UniProtKB=Q9CR50	RING finger and CHY zinc finger domain-containing protein 1	ISS	607680	OMIM	PTHR21319:SF20	RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MACMU|Gene=CXCR4|UniProtKB=P79394	C-X-C chemokine receptor type 4	ISS	4503175	gi	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=98961|UniProtKB=P24383	Protein Wnt-7a	TAS	8717036	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00006	Apoptosis signaling pathway	P00303	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00053	T cell activation	P01300	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05913	Enkephalin release	P05972	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00054	Toll receptor signaling pathway	P01356	ERK2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00021	FGF signaling pathway	P00636	FGFR1-4	CANLF|Ensembl=ENSCAFG00000005970|UniProtKB=E2R186	Fibroblast growth factor receptor	ISS	1708247	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000013587|UniProtKB=F7AZ16	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF33	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-3
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MONDO|Ensembl=ENSMODG00000009983|UniProtKB=F6USY2	Uncharacterized protein	ISS	9006902	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00030	Hypoxia response via HIF activation	P00819	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02738	De novo purine biosynthesis	P02908	Phosphoribosylamine glycine ligase	CANLF|Ensembl=ENSCAFG00000030829|UniProtKB=F1PTG8	Uncharacterized protein	ISS			PTHR10520:SF10	TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DICDI|dictyBase=DDB_G0268744|UniProtKB=Q55EU6	Putative actin-23	ISS	14684598	PubMed	PTHR11937:SF154	ACTIN-17-RELATED
P05913	Enkephalin release	P05971	CREB	CHICK|Ensembl=ENSGALG00000008494|UniProtKB=Q7SX83	CAMP response element-binding protein	ISS	11752053	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000000365|UniProtKB=F6R9F4	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04398	p53 pathway feedback loops 2	P04657	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01448	CBP	CAEEL|WormBase=WBGene00010545|UniProtKB=G5EBG3	CBP/p300 homolog	ISS	10769018	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	CAEEL|WormBase=WBGene00006774|UniProtKB=Q23022	Acetylcholine receptor subunit alpha-type unc-38	ISS	85270494	PubMed	PTHR18945:SF769	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-TYPE UNC-38
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00022	General transcription by RNA polymerase I	P00649	TAF-IC	BOVIN|Ensembl=ENSBTAG00000011339|UniProtKB=A7MAZ4	Transcription initiation factor TFIID subunit 8	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MOUSE|MGI=MGI=1915021|UniProtKB=Q9CPW4	Actin-related protein 2/3 complex subunit 5	ISS	12932731	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	CANLF|Ensembl=ENSCAFG00000005035|UniProtKB=F1PGW4	Serine/threonine-protein kinase receptor	ISS	9395284	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P00019	Endothelin signaling pathway	P00577	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	ISS	12660731	PubMed	PTHR10048:SF14	PI-3 KINASE
P00029	Huntington disease	P00807	Actin	CAEEL|WormBase=WBGene00000065|UniProtKB=P0DM42	Actin-3	IDA	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00006	Apoptosis signaling pathway	P00310	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=94927|UniProtKB=Q8BLD9	D(1B) dopamine receptor	ISS			PTHR43893:SF8	D 1B  DOPAMINE RECEPTOR
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	CANLF|Ensembl=ENSCAFG00000004381|UniProtKB=J9JH96	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CANLF|Ensembl=ENSCAFG00000017262|UniProtKB=F1PVV7	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF328	MYOSIN-10
P00053	T cell activation	P01319	PAK	ORNAN|Ensembl=ENSOANG00000002406|UniProtKB=F7BAS2	Uncharacterized protein	ISS	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IDA	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04393	Ras Pathway	P04542	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00006	Apoptosis signaling pathway	P00269	MAPK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00297	NFkappaB	RAT|RGD=1307189|UniProtKB=Q5U2Z4	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	ISS	9133421	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	LEIMA|EnsemblGenome=LmjF.28.2370|UniProtKB=Q4Q828	Serine hydroxymethyltransferase	ISS			PTHR11680:SF28	SERINE HYDROXYMETHYLTRANSFERASE 1
P06959	CCKR signaling map	P07227	KLF4	HUMAN|HGNC=6348|UniProtKB=O43474	Krueppel-like factor 4	RCA	8662934	PubMed	PTHR44778:SF1	KRUEPPEL-LIKE FACTOR 4
P05918	p38 MAPK pathway	P06021	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	HUMAN|HGNC=5465|UniProtKB=P08069	Insulin-like growth factor 1 receptor	TAS	2877871	PubMed	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00021	FGF signaling pathway	P00641	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00010	B cell activation	P00369	MEKK	RAT|RGD=1304575|UniProtKB=B5DF98	Map3k3 protein	ISS	11730323	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00629	PP2A	CANLF|Ensembl=ENSCAFG00000001753|UniProtKB=F1P714	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_188187|UniProtKB=E9GJ31	Guanine nucleotide binding protein, q polypeptide	ISS	8457205	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	BOVIN|Gene=CACNB1|UniProtKB=Q9MZL7	Voltage-dependent L-type calcium channel subunit beta-1	ISS	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MONDO|Ensembl=ENSMODG00000000771|UniProtKB=F6SSS3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00053	T cell activation	P01324	rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00005	Angiogenesis	P00209	FAK	CANLF|Ensembl=ENSCAFG00000001217|UniProtKB=E2RGP8	Uncharacterized protein (Fragment)	ISS	9182576	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	MACMU|Ensembl=ENSMMUG00000001758|UniProtKB=F6TN15	Uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF84	CASEIN KINASE I ISOFORM ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=71083|UniProtKB=P30940	5-hydroxytryptamine receptor 1F	IDA	11701344	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00052	TGF-beta signaling pathway	P01284	JNK	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00019	Endothelin signaling pathway	P00589	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	IGI	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IDA	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00047	PDGF signaling pathway	P01160	IP3 receptor	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	TAKRU|Ensembl=ENSTRUG00000009259|UniProtKB=H2TF39	Uncharacterized protein	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	BOVIN|Ensembl=ENSBTAG00000006377|UniProtKB=F1MFG9	Uncharacterized protein	ISS			PTHR13140:SF381	UNCONVENTIONAL MYOSIN-IG
P00017	DNA replication	P00536	DNA Topisomerase	DROME|FlyBase=FBgn0003732|UniProtKB=P15348	DNA topoisomerase 2	ISS			PTHR10169:SF38	DNA TOPOISOMERASE 2
P00019	Endothelin signaling pathway	P00591	PLCbeta	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	IGI	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000008536|UniProtKB=F6WBZ5	Mitogen-activated protein kinase	ISS	15085193	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00571	Pro ET1-4	RAT|RGD=2532|UniProtKB=P22388	Endothelin-1	ISS	15117818	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	ORNAN|Ensembl=ENSOANG00000007405|UniProtKB=F7CIV4	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	TAS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00034	Integrin signalling pathway	P00941	Integrin alpha	BOVIN|Gene=ITGA2|UniProtKB=P53710	Integrin alpha-2 (Fragment)	IPI	3487386	PubMed	PTHR23220:SF23	INTEGRIN ALPHA-2
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P02751	Lysine biosynthesis	P03008	Dihydrodipicolinate synthase	BACSU|EnsemblGenome=BSU16770|UniProtKB=Q04796	4-hydroxy-tetrahydrodipicolinate synthase	ISS			PTHR12128:SF15	4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL
P04384	Gamma-aminobutyric acid synthesis	P04482	Glutamate decarboxylase	CANLF|Gene=GAD2|UniProtKB=Q4PRC2	Glutamate decarboxylase 2	ISS	2247446	PubMed	PTHR11999:SF77	GLUTAMATE DECARBOXYLASE 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00642	MEK1-2	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04393	Ras Pathway	P04563	Ets	MOUSE|MGI=MGI=95455|UniProtKB=P27577	Protein C-ets-1	ISS	9157999	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00034	Integrin signalling pathway	P00938	Cdc42	XENTR|Xenbase=XB-GENE-967585|UniProtKB=Q28BZ0	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00049	Parkinson disease	P01242	Casein kinase I	DROME|FlyBase=FBgn0015024|UniProtKB=P54367	Casein kinase I isoform alpha	IDA	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00029	Huntington disease	P00797	p53	HUMAN|HGNC=11998|UniProtKB=P04637	Cellular tumor antigen p53	TAS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00059	p53 pathway	P01486	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00318	PKCs	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00006	Apoptosis signaling pathway	P00273	p53	CANLF|Gene=TP53|UniProtKB=Q29537	Cellular tumor antigen p53	ISS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P02747	Histidine biosynthesis	P02987	ATP phosphoribosyl transferase	DEIRA|EnsemblGenome=DR_1445|UniProtKB=Q9RUE2	ATP phosphoribosyltransferase	ISS			PTHR21403:SF4	ATP PHOSPHORIBOSYLTRANSFERASE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P02775	Salvage pyrimidine ribonucleotides	P03155	Cytosine deaminase	MACMU|Ensembl=ENSMMUG00000005362|UniProtKB=F7GAS0	Uncharacterized protein	ISS			PTHR11079:SF92	TRNA-SPECIFIC ADENOSINE DEAMINASE 2
P00053	T cell activation	P01309	fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	TAS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00034	Integrin signalling pathway	P00949	Shc	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	IPI	95096035	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	XENTR|Xenbase=XB-GENE-999035|UniProtKB=F7CEB1	Uncharacterized protein	ISS	10956649	PubMed	PTHR42884:SF1	FURIN
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	PANTR|Ensembl=ENSPTRG00000012128|UniProtKB=H2QI87	Uncharacterized protein	ISS	11266476	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00059	p53 pathway	P04609	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g169611|UniProtKB=A7SEB1	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	HUMAN|HGNC=16767|UniProtKB=Q8TCU5	Glutamate receptor ionotropic, NMDA 3A	IC	11319238	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00029	Huntington disease	P00780	Microtubule	BOVIN|Ensembl=ENSBTAG00000004624|UniProtKB=E1B953	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	ISS	11535291	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P04398	p53 pathway feedback loops 2	P04651	Ras	EMENI|EnsemblGenome=CADANIAG00002552|UniProtKB=Q12526	Ras-like protein	ISS	7997267	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	DROME|FlyBase=FBgn0005674|UniProtKB=P28668	Bifunctional glutamate/proline--tRNA ligase	ISS			PTHR43382:SF2	BIFUNCTIONAL GLUTAMATE/PROLINE--TRNA LIGASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	HUMAN|HGNC=6857|UniProtKB=Q99683	Mitogen-activated protein kinase kinase kinase 5	IGI	11730323	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00012	Cadherin signaling pathway	P00470	F-actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	ISS	11889139	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00053	T cell activation	P01333	cdc42	DANRE|ZFIN=ZDB-GENE-030131-8783|UniProtKB=Q52WY2	Ras-like protein Cdc42a	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00016	Cytoskeletal regulation by Rho GTPase	P00510	mDia	HUMAN|HGNC=2877|UniProtKB=O60879	Protein diaphanous homolog 2	ISS			PTHR23213:SF174	PROTEIN DIAPHANOUS HOMOLOG 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	NAS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00048	PI3 kinase pathway	P01192	p110	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DAPPU|EnsemblGenome=DAPPUDRAFT_228751|UniProtKB=E9HGF5	Cytoplasmatic actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00021	FGF signaling pathway	P00637	MKK4,7	CHICK|Ensembl=ENSGALG00000001001|UniProtKB=F1P3T1	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	DANRE|ZFIN=ZDB-GENE-051202-1|UniProtKB=E7F101	Uncharacterized protein	ISS	92049750	PubMed	PTHR44391:SF2	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01199	Galpha	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00545	JNK1-3	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04558	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	CANLF|Gene=PSEN1|UniProtKB=Q6RH31	Presenilin-1	ISS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00024	Glycolysis	P00679	Aldolase	BOVIN|Ensembl=ENSBTAG00000012927|UniProtKB=A6QLL8	Fructose-bisphosphate aldolase	ISS	84261525	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P05918	p38 MAPK pathway	P06043	ASK1	BOVIN|Ensembl=ENSBTAG00000009065|UniProtKB=F1MXH6	Uncharacterized protein	ISS	8974401	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=17175|UniProtKB=Q9P212	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	12860966	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	TAS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00046	Oxidative stress response	P01138	MKK4	RAT|RGD=1311192|UniProtKB=A0A0G2K3R1	Protein Map3k4	ISS	97236778	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00008	Axon guidance mediated by Slit/Robo	P00344	Netrin	BOVIN|Ensembl=ENSBTAG00000003183|UniProtKB=A7MB18	NTN4 protein	ISS	2538453	PubMed	PTHR10574:SF282	NETRIN-4
P00034	Integrin signalling pathway	P00925	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00056	VEGF signaling pathway	P01407	Erk	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04574	PLD	PANTR|Ensembl=ENSPTRG00000008610|UniProtKB=H2QBY9	Uncharacterized protein	ISS	9538008	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P00036	Interleukin signaling pathway	P00983	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	TAS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00205	GAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	8262392	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000006342|UniProtKB=H2Q8A8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	CANLF|Ensembl=ENSCAFG00000004882|UniProtKB=F1PAE3	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00019	Endothelin signaling pathway	P00573	signal peptidase	CAEEL|WormBase=WBGene00021844|UniProtKB=Q9N3D0	Signal peptidase complex catalytic subunit SEC11	ISS	2674115	PubMed	PTHR10806:SF6	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00029	Huntington disease	P00786	ARF	DANRE|ZFIN=ZDB-GENE-040718-175|UniProtKB=Q6DGK1	Uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P00018	EGF receptor signaling pathway	P00558	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00048	PI3 kinase pathway	P01181	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00057	Wnt signaling pathway	P01465	Ggamma	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00005	Angiogenesis	P00186	FGFR-1	CANLF|Ensembl=ENSCAFG00000005970|UniProtKB=E2R186	Fibroblast growth factor receptor	ISS	12799194	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	PANTR|Ensembl=ENSPTRG00000034127|UniProtKB=H2RDU2	Uncharacterized protein	ISS	10048442	gi	PTHR24230:SF8	LEUKOTRIENE B4 RECEPTOR 2
P04393	Ras Pathway	P04572	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04376	5HT4 type receptor mediated signaling pathway	P04426	K+ channel	MONDO|Ensembl=ENSMODG00000015769|UniProtKB=F6ZSC2	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IDA	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	MACMU|Ensembl=ENSMMUG00000012305|UniProtKB=F7DLC9	Tyrosine-protein kinase receptor	ISS	249616	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00006	Apoptosis signaling pathway	P00269	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	RAT|RGD=61800|UniProtKB=P14842	5-hydroxytryptamine receptor 2A	ISS	12441358	PubMed	PTHR24247:SF30	5-HYDROXYTRYPTAMINE RECEPTOR 2A
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_58093|UniProtKB=C3Z4K3	Putative uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00021	FGF signaling pathway	P00645	Rac	DICDI|dictyBase=DDB_G0293526|UniProtKB=P34149	Rho-related protein racC	ISS	12932731	PubMed	PTHR24072:SF117	RHO-RELATED PROTEIN RACC
P00036	Interleukin signaling pathway	P00965	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000013587|UniProtKB=F7AZ16	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF33	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-3
P00059	p53 pathway	G04702	p53	HUMAN|HGNC=12003|UniProtKB=O15350	Tumor protein p73	TAS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00053	T cell activation	P01322	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	IGI	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00030	Hypoxia response via HIF activation	P00819	AKT	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	IC	98382502	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IPI	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00048	PI3 kinase pathway	P01192	p110	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	IGI	14505573	PubMed	PTHR10048:SF14	PI-3 KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06773	gnai/o	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	RCA	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P02738	De novo purine biosynthesis	P02907	dADP kinase	PANTR|Ensembl=ENSPTRG00000007605|UniProtKB=H2QAA6	Nucleoside diphosphate kinase	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04396	Vitamin D metabolism and pathway	P04603	1alpha-Hydroxylase	PANTR|Ensembl=ENSPTRG00000012425|UniProtKB=H2QIN6	Uncharacterized protein	ISS	11013342	PubMed	PTHR24291:SF9	CYTOCHROME P450 27C1
P00056	VEGF signaling pathway	P01414	PLC-gamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	RCA	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P05918	p38 MAPK pathway	P06031	p38alpha	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	RCA	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	ARATH|TAIR=AT4G33200|UniProtKB=Q0WPU1	Myosin-15	IC			PTHR13140:SF534	MYOSIN-15
P00029	Huntington disease	P00807	Actin	EMENI|EnsemblGenome=CADANIAG00007315|UniProtKB=P20359	Actin, gamma	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000002245|UniProtKB=H2RYC6	Uncharacterized protein (Fragment)	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00052	TGF-beta signaling pathway	P01284	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	TAS	97102675	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00057	Wnt signaling pathway	P01443	Phospholipase C	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00018	EGF receptor signaling pathway	P00549	EGF	RAT|RGD=2526|UniProtKB=Q06175	Proheparin-binding EGF-like growth factor	IGI	12746188	PubMed	PTHR10740:SF4	PROHEPARIN-BINDING EGF-LIKE GROWTH FACTOR
P00029	Huntington disease	P00807	Actin	BOVIN|Ensembl=ENSBTAG00000006189|UniProtKB=P63258	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IDA	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00019	Endothelin signaling pathway	P00572	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	MACMU|Ensembl=ENSMMUG00000004886|UniProtKB=F7AGT9	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	RAT|RGD=61862|UniProtKB=P19491	Glutamate receptor 2	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	HUMAN|HGNC=5301|UniProtKB=P50406	5-hydroxytryptamine receptor 6	IDA	12441358	PubMed	PTHR24247:SF114	5-HYDROXYTRYPTAMINE RECEPTOR 6
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	RAT|RGD=1359133|UniProtKB=Q6AY07	Fructose-bisphosphate aldolase	ISS	74094688	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00034	Integrin signalling pathway	P00923	Arf1	BOVIN|Ensembl=ENSBTAG00000011883|UniProtKB=Q2YDM1	ADP-ribosylation factor-like protein 1	ISS	12932731	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00162	Pro-BACE-1	MONDO|Ensembl=ENSMODG00000013692|UniProtKB=F6QP52	Uncharacterized protein	ISS	10956649	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PLAF7|EnsemblGenome=PFL2215w|UniProtKB=Q8I4X0	Actin-1	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	ORNAN|Ensembl=ENSOANG00000011059|UniProtKB=F7FKP7	Uncharacterized protein	ISS			PTHR11405:SF38	CARBAMOYL-PHOSPHATE SYNTHASE  AMMONIA , MITOCHONDRIAL
P00005	Angiogenesis	P00226	Delta/Serrate	XENTR|Xenbase=XB-GENE-485662|UniProtKB=F7ENN2	Delta-like protein	ISS	11685570	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	8170357	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00004	Alzheimer disease-presenilin pathway	P00125	Ire-1 C-terminal fragment	ARATH|TAIR=AT3G11870|UniProtKB=Q9SF12	Inactive serine/threonine-protein kinase/endoribonuclease IRE1-like	IDA	10619423	PubMed	PTHR13954:SF6	INOSITOL-REQUIRING ENZYME-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	SCHPO|PomBase=SPBC32H8.12c|UniProtKB=P10989	Actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	MACMU|Ensembl=ENSMMUG00000010184|UniProtKB=F6SR09	Uncharacterized protein	ISS	92317054	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	MOUSE|MGI=MGI=1351340|UniProtKB=Q9QYS2	Metabotropic glutamate receptor 3	ISS	20012997	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00053	T cell activation	P01296	TCR zeta	CHICK|Ensembl=ENSGALG00000015441|UniProtKB=E1C600	Uncharacterized protein	IGI	9012833	PubMed	PTHR10035:SF2	T-CELL SURFACE GLYCOPROTEIN CD3 ZETA CHAIN
P00035	Interferon-gamma signaling pathway	P00956	SOCS	CHICK|Ensembl=ENSGALG00000011295|UniProtKB=F1NXQ8	Uncharacterized protein	TAS	15032587	PubMed	PTHR44396:SF2	SUPPRESSOR OF CYTOKINE SIGNALING 2
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MONDO|Ensembl=ENSMODG00000000771|UniProtKB=F6SSS3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	IGI	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P05915	Opioid proenkephalin pathway	P05990	K+ channel	MONDO|Ensembl=ENSMODG00000015769|UniProtKB=F6ZSC2	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00053	T cell activation	P01309	fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	TAS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00006	Apoptosis signaling pathway	P00264	c-IAP1,2	MOUSE|MGI=MGI=1197007|UniProtKB=O08863	Baculoviral IAP repeat-containing protein 3	ISS			PTHR10044:SF99	BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 3
P05917	Opioid proopiomelanocortin pathway	P06007	alpha-MSH	MONDO|Ensembl=ENSMODG00000015853|UniProtKB=Q95J84	Proopiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00048	PI3 kinase pathway	P01192	p110	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P04611	P300	PANTR|Ensembl=ENSPTRG00000014418|UniProtKB=H2QLS0	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P02776	Serine glycine biosynthesis	P03157	Phosphoserine aminotransferase	SCHPO|PomBase=SPAC1F12.07|UniProtKB=Q10349	Putative phosphoserine aminotransferase	ISS			PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	IGI	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01408	Akt/PKB	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05918	p38 MAPK pathway	P06026	MEKK4	BOVIN|Ensembl=ENSBTAG00000020079|UniProtKB=F1N3T0	Uncharacterized protein	ISS	602425	OMIM	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P04393	Ras Pathway	P04561	SRF	CANLF|Ensembl=ENSCAFG00000001829|UniProtKB=F1PH12	Uncharacterized protein	ISS	15326221	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000020887|UniProtKB=F1MP22	Uncharacterized protein	ISS	11976940	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00057	Wnt signaling pathway	P01472	Histone deacetylase	TAKRU|Ensembl=ENSTRUG00000005364|UniProtKB=H2SKE2	Histone deacetylase	IDA	12665570	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	PANTR|Ensembl=ENSPTRG00000004701|UniProtKB=H2Q5G9	Low density lipoprotein receptor-related protein 6	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95811|UniProtKB=Q9Z2W8	Glutamate receptor 4	ISS	12941441	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00037	Ionotropic glutamate receptor pathway	P01026	KA	PANTR|Ensembl=ENSPTRG00000011042|UniProtKB=H2QGF5	Uncharacterized protein	ISS	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04393	Ras Pathway	P04544	Grb2	XENTR|Xenbase=XB-GENE-6070000|UniProtKB=Q66II3	Growth factor receptor-bound protein 2	ISS	12748278	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P02746	Heme biosynthesis	P02980	Coproporphyrinogen Oxidase (oxygen dependent)	SCHPO|PomBase=SPAC222.11|UniProtKB=Q9UTE2	Probable oxygen-dependent coproporphyrinogen-III oxidase	ISS			PTHR10755:SF0	OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL
P00021	FGF signaling pathway	P00635	FRS2	MONDO|Ensembl=ENSMODG00000020378|UniProtKB=F7F6D5	Uncharacterized protein	ISS	12571252	PubMed	PTHR21258:SF40	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	PANTR|Ensembl=ENSPTRG00000012660|UniProtKB=H2QJ07	Activating transcription factor 2	ISS	10487205	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	SCHPO|PomBase=SPBC1347.06c|UniProtKB=P40233	Casein kinase I homolog 1	IDA	11437445	PubMed	PTHR11909:SF155	GILGAMESH, ISOFORM L
P00025	Hedgehog signaling pathway	P00691	CBP	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00054	Toll receptor signaling pathway	G01550	Gene trancription	MACMU|Ensembl=ENSMMUG00000016857|UniProtKB=F7BWZ9	Uncharacterized protein	ISS	11861541	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	RCA			PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02783	Tryptophan biosynthesis	P03209	Anthranilate phosphoribosyl transferase	NEUCR|EnsemblGenome=EFNCRG00000000483|UniProtKB=P00908	Multifunctional tryptophan biosynthesis protein	ISS			PTHR43418:SF4	MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN
P00005	Angiogenesis	P00243	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	3449797	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00017	DNA replication	P00527	Histones	HUMAN|HGNC=4778|UniProtKB=Q16695	Histone H3.1t	ISS	12413958	PubMed	PTHR11426:SF184	HISTONE H3.1T
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01465	Ggamma	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00640	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00008	Axon guidance mediated by Slit/Robo	P00345	Mena	CHICK|Ensembl=ENSGALG00000009303|UniProtKB=F6QJK6	Uncharacterized protein	ISS			PTHR11202:SF1	PROTEIN ENABLED HOMOLOG
P02736	Coenzyme A biosynthesis	P02884	Dephospho-CoA kinase	PANTR|Ensembl=ENSPTRG00000009294|UniProtKB=H2QD83	Dephospho-CoA kinase domain containing	ISS			PTHR10695:SF35	DEPHOSPHO-COA KINASE DOMAIN-CONTAINING PROTEIN
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	RAT|RGD=71027|UniProtKB=P42264	Glutamate receptor ionotropic, kainate 3	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00018	EGF receptor signaling pathway	P00539	14-3-3	CANLF|Ensembl=ENSCAFG00000031015|UniProtKB=J9P6N4	Uncharacterized protein	ISS	14593000	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00019	Endothelin signaling pathway	P00591	PLCbeta	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	IC	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00012	Cadherin signaling pathway	P00470	F-actin	GIAIC|EnsemblGenome=GL50803_40817|UniProtKB=A8BV70	Actin related protein	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00005	Angiogenesis	P00186	FGFR-1	ORNAN|Ensembl=ENSOANG00000003252|UniProtKB=F6SM70	Fibroblast growth factor receptor	ISS	12799194	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P00006	Apoptosis signaling pathway	P00318	PKCs	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00060	Ubiquitin proteasome pathway	P01491	E2	CANLF|Ensembl=ENSCAFG00000001019|UniProtKB=E2RRR7	Uncharacterized protein	ISS			PTHR43898:SF6	UBIQUITIN-CONJUGATING ENZYME E2 B
P05914	Nicotine degradation	P05979	FMO3	PANTR|Gene=FMO3|UniProtKB=Q7YS44	Dimethylaniline monooxygenase [N-oxide-forming] 3	ISS	1446003	PubMed	PTHR23023:SF44	DIMETHYLANILINE MONOOXYGENASE  N-OXIDE-FORMING  3
P00060	Ubiquitin proteasome pathway	P01492	E1	ARATH|TAIR=AT2G32410|UniProtKB=Q9ZV69	NEDD8-activating enzyme E1 regulatory subunit AXL	ISS			PTHR10953:SF29	NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04651	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00053	T cell activation	P01324	rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	PANTR|Ensembl=ENSPTRG00000010295|UniProtKB=H2QF07	Uncharacterized protein	RCA			PTHR22952:SF98	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 3
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00005	Angiogenesis	P00229	SPK	HUMAN|HGNC=18859|UniProtKB=Q9NRA0	Sphingosine kinase 2	ISS			PTHR12358:SF40	SPHINGOSINE KINASE 2
P04393	Ras Pathway	P04557	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IDA	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	9860142	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=69424|UniProtKB=Q99P84	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	TAS			PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P04395	Vasopressin synthesis	P04599	Amidating Enzyme	RAT|RGD=3252|UniProtKB=P14925	Peptidyl-glycine alpha-amidating monooxygenase	IC	3153462	PubMed	PTHR10680:SF14	PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00632	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01451	Galpha	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IDA	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MONDO|Ensembl=ENSMODG00000008463|UniProtKB=F7GET1	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF196	REGULATOR OF G-PROTEIN SIGNALING 17
P04393	Ras Pathway	P04566	Stat 1/3	CANLF|Ensembl=ENSCAFG00000015213|UniProtKB=E2RB82	Signal transducer and activator of transcription	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00018	EGF receptor signaling pathway	P00552	Ras	CANLF|Ensembl=ENSCAFG00000003604|UniProtKB=E2R5G6	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF245	RAS-RELATED PROTEIN R-RAS
P04393	Ras Pathway	P04556	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00003	Alzheimer disease-amyloid secretase pathway	P00093	Tip60	MOUSE|MGI=MGI=1888527|UniProtKB=O88888	Amyloid beta A4 precursor protein-binding family A member 3	IC			PTHR12345:SF9	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 3
P04393	Ras Pathway	P04542	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00547	PP2A	XENTR|Xenbase=XB-GENE-957248|UniProtKB=Q6GLE6	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	HUMAN|HGNC=9508|UniProtKB=P49768	Presenilin-1	TAS	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=1954|UniProtKB=P08912	Muscarinic acetylcholine receptor M5	IDA			PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00034	Integrin signalling pathway	P00907	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347736|UniProtKB=E9FRT1	Muscle-specific actin	ISS	14684598	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00018	EGF receptor signaling pathway	P00557	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DROME|FlyBase=FBgn0001105|UniProtKB=P26308	Guanine nucleotide-binding protein subunit beta-1	IC	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P05916	Opioid prodynorphin pathway	P05999	provasopressin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00053	T cell activation	P01332	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01179	PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00053	T cell activation	P01324	rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS			PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00056	VEGF signaling pathway	P01422	eNOS	RAT|RGD=3186|UniProtKB=Q62600	Nitric oxide synthase, endothelial	ISS	10435050	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00029	Huntington disease	P00780	Microtubule	DROME|FlyBase=FBgn0003887|UniProtKB=Q24560	Tubulin beta-1 chain	IDA	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	RCA			PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00012	Cadherin signaling pathway	P00470	F-actin	PLAF7|EnsemblGenome=PF14_0124|UniProtKB=Q8ILW9	Actin-2	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00005	Angiogenesis	P00218	STAT1	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	15825084	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00010	B cell activation	P00371	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	RAT|RGD=621705|UniProtKB=Q8VHN2	Glutamate receptor ionotropic, NMDA 3B	IC	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IGI	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=2136749|UniProtKB=Q6PB90	Protocadherin beta-14	IDA	8120095	PubMed	PTHR24028:SF139	PROTOCADHERIN BETA-14
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PHYPA|Gene=PHYPADRAFT_198730|UniProtKB=Q6TYS2	Actin 1	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00223	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P01486	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	14744463	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00029	Huntington disease	P00796	Kainate receptor	CHICK|Ensembl=ENSGALG00000002098|UniProtKB=F1P0L4	Uncharacterized protein	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P04398	p53 pathway feedback loops 2	P04651	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DANRE|ZFIN=ZDB-GENE-040426-1178|UniProtKB=Q7SY24	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	DANRE|ZFIN=ZDB-GENE-031117-1|UniProtKB=A4FTT3	Rbpja protein	ISS	12145413	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_127489|UniProtKB=C3XYC6	Putative uncharacterized protein	IDA	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P06664	Gonadotropin-releasing hormone receptor pathway	P06860	Rac1	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	RCA	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	BOVIN|Ensembl=ENSBTAG00000016552|UniProtKB=A5PK70	Nucleoside diphosphate kinase	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHICK|Ensembl=ENSGALG00000009844|UniProtKB=P68034	Actin, alpha cardiac muscle 1	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00053	T cell activation	P01319	PAK	BOVIN|Ensembl=ENSBTAG00000047856|UniProtKB=G3MZE2	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00053	T cell activation	P01330	IKK	MOUSE|MGI=MGI=1338071|UniProtKB=O88351	Inhibitor of nuclear factor kappa-B kinase subunit beta	IGI	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05935	AngII	HUMAN|HGNC=333|UniProtKB=P01019	Angiotensinogen	RCA			PTHR11461:SF13	ANGIOTENSINOGEN
P00059	p53 pathway	P01486	Akt	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	TAS	14526383	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00580	ET-RA/B	PANTR|Ensembl=ENSPTRG00000016494|UniProtKB=H2QQ94	Endothelin receptor type A	ISS	8564193	PubMed	PTHR24243:SF31	ENDOTHELIN-1 RECEPTOR
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01428	Frizzled	BOVIN|Ensembl=ENSBTAG00000040128|UniProtKB=F1MLJ8	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF23	FRIZZLED-4
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MOUSE|MGI=MGI=1336171|UniProtKB=Q9DAS9	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MOUSE|MGI=MGI=105062|UniProtKB=Q8K592	Anti-Muellerian hormone type-2 receptor	TAS	9759503	PubMed	PTHR23255:SF49	ANTI-MUELLERIAN HORMONE TYPE-2 RECEPTOR
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05912	Dopamine receptor mediated signaling pathway	P05950	DARPP-32	HUMAN|HGNC=9287|UniProtKB=Q9UD71	Protein phosphatase 1 regulatory subunit 1B	ISS	3339428	PubMed	PTHR15417:SF2	PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 1B
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00896	Insulin IGF	BOVIN|Gene=INS|UniProtKB=P01317	Insulin	ISS			PTHR11454:SF9	INSULIN-RELATED
P00020	FAS signaling pathway	P00608	Pro-Caspase3	HUMAN|HGNC=1504|UniProtKB=P42574	Caspase-3	IGI	7983002	PubMed	PTHR10454:SF198	CASPASE-3
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MACMU|Ensembl=ENSMMUG00000022147|UniProtKB=F7H3A4	Uncharacterized protein	ISS	85203892	PubMed	PTHR18945:SF61	ACETYLCHOLINE RECEPTOR SUBUNIT DELTA
P00006	Apoptosis signaling pathway	P00314	MKK3	CHICK|Ensembl=ENSGALG00000004735|UniProtKB=F1NHE1	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00036	Interleukin signaling pathway	P00973	PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	CANLF|Ensembl=ENSCAFG00000009398|UniProtKB=Q6UKZ8	Growth/differentiation factor 8	TAS	9759503	PubMed	PTHR11848:SF150	GROWTH/DIFFERENTIATION FACTOR 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00709	Glycogen synthase D	BOVIN|Ensembl=ENSBTAG00000013333|UniProtKB=E1B9X7	Uncharacterized protein	ISS	4212312	PubMed	PTHR10176:SF1	GLYCOGEN  STARCH  SYNTHASE, LIVER
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04559	Rac	DICDI|dictyBase=DDB_G0279605|UniProtKB=P34148	Rho-related protein racB	ISS	94124042	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P05731	GABA-B receptor II signaling	P05760	AC	HUMAN|HGNC=237|UniProtKB=O43306	Adenylate cyclase type 6	RCA	10978539	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	IC	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00029	Huntington disease	P00780	Microtubule	ARATH|TAIR=AT5G62690|UniProtKB=Q56YW9	Tubulin beta-2 chain	IDA	9454836	PubMed	PTHR11588:SF259	TUBULIN BETA-2 CHAIN-RELATED
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	PANTR|Ensembl=ENSPTRG00000003983|UniProtKB=H2Q4A0	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P04393	Ras Pathway	P04559	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MOUSE|MGI=MGI=95819|UniProtKB=P35438	Glutamate receptor ionotropic, NMDA 1	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	MACMU|Ensembl=ENSMMUG00000011442|UniProtKB=F7B9T3	Ras-related protein Rap-1b	ISS	8576107	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00012	Cadherin signaling pathway	P00475	Frizzled	PANTR|Ensembl=ENSPTRG00000009279|UniProtKB=H2QD74	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF34	FRIZZLED-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MONDO|Ensembl=ENSMODG00000007194|UniProtKB=F6X9N6	Actin-related protein 2/3 complex subunit 5	ISS	12932731	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00217	STAT3	PANTR|Ensembl=ENSPTRG00000009200|UniProtKB=H2QD20	Signal transducer and activator of transcription	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00034	Integrin signalling pathway	P00924	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IPI	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01275	P38	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04397	p53 pathway by glucose deprivation	P04644	TSC2	BOVIN|Ensembl=ENSBTAG00000020617|UniProtKB=E1BNT2	Uncharacterized protein	ISS	15249583	PubMed	PTHR10063:SF0	TUBERIN
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	DANRE|ZFIN=ZDB-GENE-990415-257|UniProtKB=O42376	Mitogen-activated protein kinase 12	ISS	11707292	PubMed	PTHR24055:SF339	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	DROME|FlyBase=FBgn0263111|UniProtKB=P91645	Voltage-dependent calcium channel type A subunit alpha-1	ISS	14624853	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P00047	PDGF signaling pathway	P01143	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	10875333	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00036	Interleukin signaling pathway	P00973	PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00591	PLCbeta	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04393	Ras Pathway	P04572	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04398	p53 pathway feedback loops 2	P04651	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	HUMAN|HGNC=4579|UniProtKB=P39086	Glutamate receptor ionotropic, kainate 1	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00047	PDGF signaling pathway	P01175	Shc	MOUSE|MGI=MGI=106179|UniProtKB=Q61120	SHC-transforming protein 3	ISS	8610109	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	SCHPO|PomBase=SPAC144.04c|UniProtKB=Q9UQW9	Ornithine decarboxylase	ISS			PTHR11482:SF6	ORNITHINE DECARBOXYLASE 1-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P06664	Gonadotropin-releasing hormone receptor pathway	P06700	Inhba/b	MOUSE|MGI=MGI=96570|UniProtKB=Q04998	Inhibin beta A chain	RCA			PTHR11848:SF133	INHIBIN BETA A CHAIN
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	BOVIN|Ensembl=ENSBTAG00000002295|UniProtKB=F1N177	Uncharacterized protein	ISS	15218628	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00006	Apoptosis signaling pathway	P00321	HSP70	CAEEL|WormBase=WBGene00002005|UniProtKB=P09446	Heat shock 70 kDa protein A	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P02755	Methylmalonyl pathway	P03033	Propionyl-CoA carboxylase	BACSU|EnsemblGenome=BSU23920|UniProtKB=P54541	Putative propionyl-CoA carboxylase beta chain	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P00046	Oxidative stress response	P01129	JNK1/2	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00021	FGF signaling pathway	P00642	MEK1-2	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00054	Toll receptor signaling pathway	P01351	TLR2,4,7	PANTR|Gene=TLR2|UniProtKB=B3Y613	Toll-like receptor 2	ISS			PTHR24365:SF17	TOLL-LIKE RECEPTOR 2
P00021	FGF signaling pathway	P00624	14-3-3	DANRE|ZFIN=ZDB-GENE-061023-2|UniProtKB=E7F354	Uncharacterized protein	ISS	1317796	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00056	VEGF signaling pathway	P01408	Akt/PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	MOUSE|MGI=MGI=96603|UniProtKB=Q00651	Integrin alpha-4	IDA	3487386	PubMed	PTHR23220:SF78	INTEGRIN ALPHA-4
P00053	T cell activation	P01311	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01167	Ets	MACMU|Ensembl=ENSMMUG00000005927|UniProtKB=F6V4E5	ETS-like proteinous factor	ISS	15298723	PubMed	PTHR11849:SF171	ETS HOMOLOGOUS FACTOR
P00021	FGF signaling pathway	P00638	PLCgamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00005	Angiogenesis	P00209	FAK	CAEEL|WormBase=WBGene00002213|UniProtKB=Q95YD4	Inactive tyrosine-protein kinase kin-32	ISS			PTHR24418:SF367	FOCAL ADHESION KINASE, ISOFORM D
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00034	Integrin signalling pathway	P00925	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04392	P53 pathway feedback loops 1	G04682	MDM-2	MOUSE|MGI=MGI=96952|UniProtKB=P23804	E3 ubiquitin-protein ligase Mdm2	IGI	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00006	Apoptosis signaling pathway	P00260	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00005	Angiogenesis	P00227	PLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	RAT|RGD=1309032|UniProtKB=D3ZX41	Protein Fpr-rs3	ISS			PTHR24225:SF18	FORMYL PEPTIDE RECEPTOR-RELATED SEQUENCE 3
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	MACMU|Ensembl=ENSMMUG00000010678|UniProtKB=F7AXI7	Uncharacterized protein	ISS	192340	OMIM	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00036	Interleukin signaling pathway	P00990	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00780	Microtubule	PUCGT|EnsemblGenome=PGTG_12204|UniProtKB=E3KPL3	Tubulin beta chain	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IDA	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	RAT|RGD=621705|UniProtKB=Q8VHN2	Glutamate receptor ionotropic, NMDA 3B	ISS	14698601	PubMed	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	BOVIN|Ensembl=ENSBTAG00000014600|UniProtKB=E1BQ12	Uncharacterized protein	ISS	12890691	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	CAEEL|WormBase=WBGene00009595|UniProtKB=Q7JMS5	Uncharacterized protein	IDA			PTHR13808:SF1	NEJIRE, ISOFORM C
P02757	O-antigen biosynthesis	P03045	dTDP-glucose 4,6-dehydratase	STRCO|Gene=CAB61555|UniProtKB=Q9RJE3	dTDP-glucose 4,6-dehydratase	ISS			PTHR43000:SF7	DTDP-D-GLUCOSE 4,6-DEHYDRATASE
P00056	VEGF signaling pathway	P01405	VRAP	HUMAN|HGNC=10821|UniProtKB=Q9NP31	SH2 domain-containing protein 2A	IDA	10692392	PubMed	PTHR14388:SF9	SH2 DOMAIN-CONTAINING PROTEIN 2A
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05918	p38 MAPK pathway	P05920	MAPKAP-K2	MOUSE|MGI=MGI=109298|UniProtKB=P49138	MAP kinase-activated protein kinase 2	RCA	9628873	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	RAT|RGD=2025|UniProtKB=P68136	Actin, alpha skeletal muscle	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	BOVIN|Gene=ARPC5|UniProtKB=Q3SYX9	Actin-related protein 2/3 complex subunit 5	IDA	12473693	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000003043|UniProtKB=P63212	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00005	Angiogenesis	P00214	HIF-1	MACMU|Ensembl=ENSMMUG00000021002|UniProtKB=F7HKJ2	Uncharacterized protein	ISS	9606183	PubMed	PTHR23043:SF7	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA
P00021	FGF signaling pathway	P00637	MKK4,7	CANLF|Ensembl=ENSCAFG00000017851|UniProtKB=F1PBB6	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00018	EGF receptor signaling pathway	P00561	STAT	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	ISS	12461178	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00091	Aph-1	DANRE|ZFIN=ZDB-GENE-031118-31|UniProtKB=Q8JHE9	Gamma-secretase subunit Aph-1b	ISS	12110170	PubMed	PTHR12889:SF1	GAMMA-SECRETASE SUBUNIT APH-1B
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MOUSE|MGI=MGI=98472|UniProtKB=P20293	Brachyury protein	IEP	12356903	PubMed	PTHR11267:SF83	BRACHYURY PROTEIN
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=1310389|UniProtKB=D3ZTF6	Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Predicted), isoform CRA_a	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01063	CAT	CANLF|Ensembl=ENSCAFG00000006672|UniProtKB=F1PR75	Uncharacterized protein	ISS	97225904	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P00036	Interleukin signaling pathway	P00966	mTOR	MOUSE|MGI=MGI=1928394|UniProtKB=Q9JLN9	Serine/threonine-protein kinase mTOR	ISS	14526383	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00057	Wnt signaling pathway	P01451	Galpha	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	IDA	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00006	Apoptosis signaling pathway	P00279	endoG	DROME|FlyBase=FBgn0033690|UniProtKB=Q7JXB9	Endonuclease G	ISS			PTHR13966:SF5	ENDONUCLEASE G, MITOCHONDRIAL
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00056	VEGF signaling pathway	P01404	SPK	MOUSE|MGI=MGI=1861380|UniProtKB=Q9JIA7	Sphingosine kinase 2	ISS			PTHR12358:SF40	SPHINGOSINE KINASE 2
P00025	Hedgehog signaling pathway	P00682	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	TAS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00916	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00021	FGF signaling pathway	P00633	Ras	CHICK|Ensembl=ENSGALG00000006885|UniProtKB=P08642	GTPase HRas	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IC	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00887	IRS 1-4	MOUSE|MGI=MGI=99454|UniProtKB=P35569	Insulin receptor substrate 1	ISS	5031805	gi	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00053	T cell activation	P01297	MEKK	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	RCA	8940199	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00005	Angiogenesis	P00203	Erk	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	MOUSE|MGI=MGI=87887|UniProtKB=Q8R4G9	Neuronal acetylcholine receptor subunit alpha-3	ISS	12098588	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P05912	Dopamine receptor mediated signaling pathway	P05970	TH	PANTR|Ensembl=ENSPTRG00000003173|UniProtKB=H2Q2W7	Uncharacterized protein	ISS	12814656	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00059	p53 pathway	G04689	Cyclin G	BOVIN|Ensembl=ENSBTAG00000006607|UniProtKB=Q5E9I1	Cyclin-G1	ISS	7957050	PubMed	PTHR10177:SF59	CYCLIN-G1
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00005	Angiogenesis	P00184	Src	CANLF|Ensembl=ENSCAFG00000008755|UniProtKB=E2RSH8	Tyrosine-protein kinase	ISS	8054685	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P04393	Ras Pathway	P04572	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01200	SHIP	BOVIN|Ensembl=ENSBTAG00000019167|UniProtKB=E1BBJ7	Uncharacterized protein	ISS	12145149	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	HUMAN|HGNC=465|UniProtKB=Q16671	Anti-Muellerian hormone type-2 receptor	TAS	9759503	PubMed	PTHR23255:SF49	ANTI-MUELLERIAN HORMONE TYPE-2 RECEPTOR
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	15860573	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00012	Cadherin signaling pathway	P00470	F-actin	CIOIN|Ensembl=ENSCING00000000848|UniProtKB=F6SCP4	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00560	Raf-1	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS			PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05731	GABA-B receptor II signaling	P05760	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04557	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IDA	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00047	PDGF signaling pathway	P01173	STAT	RAT|RGD=3774|UniProtKB=P52632	Signal transducer and activator of transcription 5B	ISS	96102059	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00019	Endothelin signaling pathway	P00566	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	RAT|RGD=1311275|UniProtKB=G3V7Y6	Forkhead box H1 (Predicted)	ISS	8878477	PubMed	PTHR11829:SF191	FORKHEAD BOX PROTEIN H1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01093	AChE	CANLF|Ensembl=ENSCAFG00000014054|UniProtKB=E2RP98	Carboxylic ester hydrolase	ISS	87080761	PubMed	PTHR11559:SF356	ACETYLCHOLINESTERASE
P00034	Integrin signalling pathway	P00948	Rho	YEAST|SGD=S000001763|UniProtKB=Q00246	GTP-binding protein RHO4	IGI	11973360	PubMed	PTHR24072:SF258	GTP-BINDING PROTEIN RHO4
P00014	Cholesterol biosynthesis	P00498	Hydroxymethyl glutaryl CoA synthase	BOVIN|Ensembl=ENSBTAG00000011839|UniProtKB=F6RJG0	Uncharacterized protein	ISS	123332	gi	PTHR43323:SF4	HYDROXYMETHYLGLUTARYL-COA SYNTHASE, CYTOPLASMIC
P00059	p53 pathway	P04630	PP2A	MACMU|Ensembl=ENSMMUG00000020819|UniProtKB=F7HSM1	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02916	dTMP kinase	NEUCR|EnsemblGenome=EFNCRG00000007922|UniProtKB=Q1K688	Thymidylate kinase	ISS			PTHR10344:SF1	THYMIDYLATE KINASE
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IDA	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00018	EGF receptor signaling pathway	P00552	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	3035212	PubMed	PTHR24070:SF385	GTPASE HRAS
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	MONDO|Ensembl=ENSMODG00000003244|UniProtKB=F6THF0	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	MOUSE|MGI=MGI=88296|UniProtKB=O55017	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	11976940	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MONDO|Ensembl=ENSMODG00000013970|UniProtKB=F6R6X5	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	DROME|FlyBase=FBgn0001991|UniProtKB=Q24270	Voltage-dependent calcium channel type D subunit alpha-1	ISS	9199552	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	TAS	9094314	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04393	Ras Pathway	P04570	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IC	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	12846562	PubMed	PTHR10202:SF13	PRESENILIN-2
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	MOUSE|MGI=MGI=105083|UniProtKB=P51906	Excitatory amino acid transporter 3	ISS	96032356	PubMed	PTHR11958:SF69	EXCITATORY AMINO ACID TRANSPORTER 3
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DANRE|ZFIN=ZDB-GENE-000920-1|UniProtKB=A5WW41	Uncharacterized protein	IEP	15117818	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	11832947	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00047	PDGF signaling pathway	P01161	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Gene=DRD2|UniProtKB=P20288	D(2) dopamine receptor	IDA	1319557	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	MOUSE|MGI=MGI=98878|UniProtKB=P07607	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00006	Apoptosis signaling pathway	P00269	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	9298898	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00117	E-cadherin C-terminal fragment	MOUSE|MGI=MGI=88356|UniProtKB=P10287	Cadherin-3	IDA	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	8649368	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00047	PDGF signaling pathway	P01168	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00018	EGF receptor signaling pathway	P00551	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	IGI	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DROME|FlyBase=FBgn0261854|UniProtKB=A1Z9X0	Atypical protein kinase C	ISS	15572354	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	PANTR|Ensembl=ENSPTRG00000011049|UniProtKB=H2QGF9	Glycogen synthase kinase 3 alpha	ISS	2164470	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00048	PI3 kinase pathway	P01192	p110	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	RAT|RGD=1309504|UniProtKB=D3ZRN3	Protein Actbl2	ISS	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	IDA	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00034	Integrin signalling pathway	P00922	Collagen	PANTR|Ensembl=ENSPTRG00000004871|UniProtKB=H2R193	Uncharacterized protein	ISS	10778855	PubMed	PTHR24023:SF58	COLLAGEN ALPHA-1 II  CHAIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	BOVIN|Gene=CSNK2A2|UniProtKB=P20427	Casein kinase II subunit alpha'	IDA	10617630	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01446	Calcineurin	XENTR|Xenbase=XB-GENE-961157|UniProtKB=A4IFW0	Serine/threonine-protein phosphatase	ISS	12015605	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00807	Actin	ORNAN|Ensembl=ENSOANG00000000460|UniProtKB=F7F4W9	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DANRE|ZFIN=ZDB-GENE-041001-104|UniProtKB=Q5TZD4	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00034	Integrin signalling pathway	P00931	Integrin beta	MOUSE|MGI=MGI=96610|UniProtKB=P09055	Integrin beta-1	IDA	10706722	PubMed	PTHR10082:SF28	INTEGRIN BETA-1
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00036	Interleukin signaling pathway	P00990	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00162	Pro-BACE-1	PANTR|Ensembl=ENSPTRG00000004324|UniProtKB=H2Q4U8	Beta-site APP-cleaving enzyme 1	ISS	10956649	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00006	Apoptosis signaling pathway	P00314	MKK3	MONDO|Ensembl=ENSMODG00000001404|UniProtKB=F7BD74	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00019	Endothelin signaling pathway	P00586	Gq	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00046	Oxidative stress response	P01129	JNK1/2	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04393	Ras Pathway	P04570	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	TAKRU|Ensembl=ENSTRUG00000006611|UniProtKB=H2SV11	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01423	p38MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	SCHMA|EnsemblGenome=Smp_020170|UniProtKB=G4V8E3	Voltage-dependent calcium channel (Fragment)	ISS	8386525	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	TAS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00019	Endothelin signaling pathway	P00591	PLCbeta	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00023	General transcription regulation	P00660	RNA Polymerase II	DANRE|ZFIN=ZDB-GENE-050417-66|UniProtKB=Q568H8	Uncharacterized protein	ISS	606023	OMIM	PTHR10917:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00011	Blood coagulation	P00429	PN2	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	ISS	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05918	p38 MAPK pathway	P06015	p38gamma	DANRE|ZFIN=ZDB-GENE-990415-257|UniProtKB=O42376	Mitogen-activated protein kinase 12	ISS	10851062	PubMed	PTHR24055:SF339	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DICPU|Gene=DICPUDRAFT_46519|UniProtKB=F0Z796	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	P01465	Ggamma	BOVIN|Ensembl=ENSBTAG00000035697|UniProtKB=Q28024	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IDA	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01300	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PANTR|Ensembl=ENSPTRG00000012431|UniProtKB=H2QIP0	Uncharacterized protein	ISS			PTHR13140:SF505	UNCONVENTIONAL MYOSIN-VIIB
P00019	Endothelin signaling pathway	P00590	IP3 R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00015	Circadian clock system	G01497	cry	CANLF|Ensembl=ENSCAFG00000001797|UniProtKB=E2RMX4	Uncharacterized protein	ISS	14507900	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00012	Cadherin signaling pathway	P00477	GSK3beta	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00034	Integrin signalling pathway	P00906	Rap1	HUMAN|HGNC=21165|UniProtKB=Q9Y3L5	Ras-related protein Rap-2c	IC	8576107	PubMed	PTHR24070:SF200	RAS-RELATED PROTEIN RAP-2C
P00034	Integrin signalling pathway	P00927	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04393	Ras Pathway	P04558	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	IDA	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02734	Chorismate biosynthesis	P02874	Shikimate kinase	BACTN|EnsemblGenome=BT_3393|UniProtKB=Q8A2B2	Shikimate kinase	ISS			PTHR21087:SF0	SHIKIMATE KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	MOUSE|MGI=MGI=1355272|UniProtKB=Q9DC28	Casein kinase I isoform delta	IDA	11437445	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00004	Alzheimer disease-presenilin pathway	P00145	CD44	HUMAN|HGNC=1681|UniProtKB=P16070	CD44 antigen	IDA	12223485	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P00054	Toll receptor signaling pathway	P01375	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=2685045|UniProtKB=E9QAN8	Protein Pik3c2b	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	HUMAN|HGNC=4598|UniProtKB=O15303	Metabotropic glutamate receptor 6	ISS	12351712	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00022	General transcription by RNA polymerase I	P00656	PTRF	RAT|RGD=1307685|UniProtKB=P85125	Polymerase I and transcript release factor	ISS	603198	OMIM	PTHR15240:SF3	POLYMERASE I AND TRANSCRIPT RELEASE FACTOR
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	TAS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00056	VEGF signaling pathway	P01407	Erk	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	MACMU|Ensembl=ENSMMUG00000010173|UniProtKB=F7AGU8	Presenilin	ISS	12736250	PubMed	PTHR10202:SF18	PRESENILIN-1
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00567	PKG	MACMU|Ensembl=ENSMMUG00000010844|UniProtKB=F7G3L7	cGMP-dependent protein kinase	ISS	12855709	PubMed	PTHR24353:SF68	SUBFAMILY NOT NAMED
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05912	Dopamine receptor mediated signaling pathway	P05957	K+ channel	BOVIN|Ensembl=ENSBTAG00000018193|UniProtKB=E1BHX8	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00034	Integrin signalling pathway	P00925	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00005	Angiogenesis	P00243	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P06959	CCKR signaling map	P07228	MAPK1/3	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	RCA	9374631	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05918	p38 MAPK pathway	P06022	eEF2K	BOVIN|Ensembl=ENSBTAG00000017662|UniProtKB=E1BEM1	Uncharacterized protein	ISS	11500363	PubMed	PTHR14187:SF56	EUKARYOTIC ELONGATION FACTOR 2 KINASE
P00006	Apoptosis signaling pathway	P00292	IkappaB	MOUSE|MGI=MGI=104741|UniProtKB=Q9Z1E3	NF-kappa-B inhibitor alpha	ISS	10869418	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000008269|UniProtKB=H2QBE4	Cadherin 3, type 1, P-cadherin (Placental)	ISS	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	MOUSE|MGI=MGI=1913903|UniProtKB=Q3UAW9	Transcription factor IIIB 50 kDa subunit	ISS			PTHR11618:SF5	TRANSCRIPTION FACTOR IIIB 50 KDA SUBUNIT
P05731	GABA-B receptor II signaling	P05754	Ggamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00052	TGF-beta signaling pathway	P01275	P38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	TAS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00048	PI3 kinase pathway	P01179	PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	RAT|RGD=2354|UniProtKB=P18916	Acetylcholine receptor subunit gamma	IC	95224005	PubMed	PTHR18945:SF60	ACETYLCHOLINE RECEPTOR SUBUNIT GAMMA
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00023	General transcription regulation	P00665	TFIIF	SCHPO|PomBase=SPAC19B12.05c|UniProtKB=Q9P376	RNA polymerase II subunit A C-terminal domain phosphatase	ISS			PTHR23081:SF0	RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00634	MEKK1-5	RAT|RGD=1304575|UniProtKB=B5DF98	Map3k3 protein	ISS	11730323	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	MOUSE|MGI=MGI=95816|UniProtKB=B1AS29	Glutamate receptor ionotropic, kainate 3	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00056	VEGF signaling pathway	P01417	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00021	FGF signaling pathway	P00631	Grb2	MACMU|Ensembl=ENSMMUG00000005327|UniProtKB=F7GJG7	GRB2-related adapter protein	ISS	8051109	PubMed	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	DANRE|ZFIN=ZDB-GENE-990714-3|UniProtKB=Q9YH61	Glycogen synthase kinase 3 alpha	ISS	21361340	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00057	Wnt signaling pathway	P01443	Phospholipase C	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MACMU|Ensembl=ENSMMUG00000009759|UniProtKB=F6ZIH3	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF504	MYOSIN-13
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	MOUSE|MGI=MGI=88257|UniProtKB=P28652	Calcium/calmodulin-dependent protein kinase type II subunit beta	ISS	12888804	PubMed	PTHR43940:SF3	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT BETA
P00059	p53 pathway	P01480	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00054	Toll receptor signaling pathway	P01358	ERK1	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	12471242	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04548	ATF2	MONDO|Ensembl=ENSMODG00000009514|UniProtKB=F7EVK3	Uncharacterized protein	ISS	10207617	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	MOUSE|MGI=MGI=99460|UniProtKB=Q61982	Neurogenic locus notch homolog protein 3	IDA	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P02747	Histidine biosynthesis	P02985	Histidinol dehydrogenase	YEAST|SGD=S000000535|UniProtKB=P00815	Histidine biosynthesis trifunctional protein	ISS			PTHR21256:SF2	HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00799	JNK-2	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00021	FGF signaling pathway	P00641	SOS	CHICK|Ensembl=ENSGALG00000013224|UniProtKB=F1NMA4	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	CHICK|Gene=CSNK1A1|UniProtKB=P67962	Casein kinase I isoform alpha	ISS	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00029	Huntington disease	P00786	ARF	PANTR|Ensembl=ENSPTRG00000013065|UniProtKB=H2QJN7	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF119	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 4C
P00005	Angiogenesis	P00190	RasGAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	8262392	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04393	Ras Pathway	P04552	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	HUMAN|HGNC=10934|UniProtKB=P54219	Chromaffin granule amine transporter	ISS	11443533	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00029	Huntington disease	P00807	Actin	TAKRU|Ensembl=ENSTRUG00000004787|UniProtKB=P53480	Actin, alpha cardiac	IDA	14684598	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000012789|UniProtKB=F1MWF5	Uncharacterized protein	ISS	8078925	PubMed	PTHR22968:SF9	SERINE/THREONINE-PROTEIN KINASE D1
P05912	Dopamine receptor mediated signaling pathway	P05957	K+ channel	RAT|RGD=61997|UniProtKB=O54912	Potassium channel subfamily K member 3	ISS	11875121	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00036	Interleukin signaling pathway	P00990	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01275	P38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00007	Axon guidance mediated by semaphorins	P00329	Sema4D	RAT|RGD=1310554|UniProtKB=D3ZYR4	Protein Sema4d	ISS			PTHR11036:SF18	SEMAPHORIN-4D
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04393	Ras Pathway	P04559	Rac	CHICK|Ensembl=ENSGALG00000012456|UniProtKB=Q5F337	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IGI	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01284	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	IGI	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00006	Apoptosis signaling pathway	P00259	TNF	RAT|RGD=3020|UniProtKB=Q06332	Lymphotoxin-alpha	ISS	8171322	PubMed	PTHR11471:SF31	LYMPHOTOXIN-ALPHA
P00056	VEGF signaling pathway	P01413	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	14526383	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	HUMAN|HGNC=5293|UniProtKB=P28223	5-hydroxytryptamine receptor 2A	ISS	8143856	PubMed	PTHR24247:SF30	5-HYDROXYTRYPTAMINE RECEPTOR 2A
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	CAEEL|WormBase=WBGene00000439|UniProtKB=P34326	Homeobox protein engrailed-like ceh-16	IEP	12356903	PubMed	PTHR24341:SF6	HOMEOBOX PROTEIN INVECTED-RELATED
P00046	Oxidative stress response	P01129	JNK1/2	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	CAEEL|WormBase=WBGene00000295|UniProtKB=Q9GNP0	Uncharacterized protein	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	NEUCR|EnsemblGenome=EFNCRG00000003612|UniProtKB=P05220	Tubulin beta chain	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00036	Interleukin signaling pathway	P00979	MAPKAPK2	CANLF|Ensembl=ENSCAFG00000011432|UniProtKB=F1PZ82	Uncharacterized protein	ISS			PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000005238|UniProtKB=F7BWT2	Uncharacterized protein	ISS	1608964	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00748	Gbeta5L	DANRE|ZFIN=ZDB-GENE-070112-342|UniProtKB=A1L271	Uncharacterized protein	ISS	1499560	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00021	FGF signaling pathway	P00645	Rac	ENTHI|EnsemblGenome=EHI_181250|UniProtKB=C4M5Z7	Rho family GTPase	ISS	97082968	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00057	Wnt signaling pathway	P01465	Ggamma	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00010	B cell activation	P00375	Calmodulin	CIOIN|Ensembl=ENSCING00000008616|UniProtKB=F6T2A6	Uncharacterized protein	ISS			PTHR23050:SF245	AT16150P-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04407	K+ channel	HUMAN|HGNC=6283|UniProtKB=Q9NPC2	Potassium channel subfamily K member 9	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P05731	GABA-B receptor II signaling	P05755	Gbeta	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04393	Ras Pathway	P04542	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00007	Axon guidance mediated by semaphorins	P00341	Rho	MONDO|Ensembl=ENSMODG00000012981|UniProtKB=F7CS91	Uncharacterized protein	ISS	15668138	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00030	Hypoxia response via HIF activation	P00819	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01446	Calcineurin	RAT|RGD=3383|UniProtKB=P20651	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	IDA	12091710	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00864	MEK	XENTR|Xenbase=XB-GENE-481530|UniProtKB=F6U298	Uncharacterized protein	ISS			PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P04393	Ras Pathway	P04558	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	TAS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00029	Huntington disease	P00790	beta-Tubulin	PHANO|Gene=SNOG_06790|UniProtKB=P41799	Tubulin beta chain	TAS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	MOUSE|MGI=MGI=2442252|UniProtKB=Q8VI56	Low-density lipoprotein receptor-related protein 4	IDA	11907044	PubMed	PTHR44017:SF4	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00049	Parkinson disease	P01219	SAPK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	NAS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	DANRE|ZFIN=ZDB-GENE-051202-2|UniProtKB=Q6ZM67	Uncharacterized protein	ISS	14698601	PubMed	PTHR44391:SF3	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00807	Actin	MOUSE|MGI=MGI=87904|UniProtKB=P60710	Actin, cytoplasmic 1	IDA	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000001384|UniProtKB=F7GL73	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IDA	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02747	Histidine biosynthesis	P02987	ATP phosphoribosyl transferase	YEAST|SGD=S000000857|UniProtKB=P00498	ATP phosphoribosyltransferase	ISS			PTHR21403:SF0	ATP PHOSPHORIBOSYLTRANSFERASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	1171954	gi	PTHR10048:SF14	PI-3 KINASE
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	RAT|RGD=71027|UniProtKB=P42264	Glutamate receptor ionotropic, kainate 3	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00018	EGF receptor signaling pathway	P00551	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01211	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00398	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00034	Integrin signalling pathway	P00936	PI3K	XENTR|Xenbase=XB-GENE-6067221|UniProtKB=F6Z0J4	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00005	Angiogenesis	P00181	SHP2	PANTR|Ensembl=ENSPTRG00000042397|UniProtKB=H2RIH8	Tyrosine-protein phosphatase non-receptor type	ISS	1382983	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00048	PI3 kinase pathway	P01182	Ras	CAEBR|Gene=CBG06092|UniProtKB=A8X0X5	Protein CBR-LET-60	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00037	Ionotropic glutamate receptor pathway	P01023	CaMKII	TAKRU|Ensembl=ENSTRUG00000007478|UniProtKB=H2T1I6	Uncharacterized protein	ISS	10092204	PubMed	PTHR43940:SF5	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA
P00029	Huntington disease	P00775	Rac	MONDO|Ensembl=ENSMODG00000003244|UniProtKB=F6THF0	Uncharacterized protein	ISS	97402517	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04494	TSC2	CANLF|Ensembl=ENSCAFG00000019438|UniProtKB=F1Q054	Uncharacterized protein	ISS	15249583	PubMed	PTHR10063:SF0	TUBERIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00047	PDGF signaling pathway	P01168	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02772	Pyruvate metabolism	P03137	Citrate Lyase	DEIRA|EnsemblGenome=DR_1240|UniProtKB=Q9RUZ0	Citrate lyase subunit beta-like protein	ISS			PTHR32308:SF0	CITRATE LYASE SUBUNIT BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	XENTR|Xenbase=XB-GENE-944026|UniProtKB=F6VZM7	Adenosine receptor A1 (Fragment)	ISS	12515326	PubMed	PTHR24246:SF1	ADENOSINE RECEPTOR A1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04556	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00029	Huntington disease	P00805	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	DANRE|ZFIN=ZDB-GENE-020125-5|UniProtKB=A2CG69	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF356	SUBFAMILY NOT NAMED
P00046	Oxidative stress response	P01134	cPLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00029	Huntington disease	P00790	beta-Tubulin	HUMAN|HGNC=20772|UniProtKB=Q13509	Tubulin beta-3 chain	TAS	12932731	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00057	Wnt signaling pathway	P01458	Protein Kinase C	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	IDA	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	TAKRU|Ensembl=ENSTRUG00000011280|UniProtKB=H2TUW3	Protein Wnt	TAS	8717036	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P02788	Xanthine and guanine salvage pathway	P03248	Deoxyguanosine phosphorylase	ANOGA|EnsemblGenome=AGAP005945|UniProtKB=A4Q998	AGAP005945-PA	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00018	EGF receptor signaling pathway	P00561	STAT	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	15825084	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00053	T cell activation	P01306	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00053	T cell activation	P01336	Jnk	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00008	Axon guidance mediated by Slit/Robo	P00355	Rho	MOUSE|MGI=MGI=106028|UniProtKB=Q62159	Rho-related GTP-binding protein RhoC	ISS	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01276	Co-Smads	MOUSE|MGI=MGI=894293|UniProtKB=P97471	Mothers against decapentaplegic homolog 4	TAS	10693808	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P00053	T cell activation	P01311	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02771	Pyrimidine Metabolism	P03124	Methylmalonate Semialdehyde Dehydrogenase	ARATH|TAIR=AT2G14170|UniProtKB=Q0WM29	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	ISS	15225601	gi	PTHR43866:SF5	METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE  ACYLATING , MITOCHONDRIAL
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00029	Huntington disease	P00774	Dynein complex	BOVIN|Ensembl=ENSBTAG00000047240|UniProtKB=E1B7A3	Uncharacterized protein	ISS	9454836	PubMed	PTHR11886:SF52	DYNEIN LIGHT CHAIN 1, CYTOPLASMIC
P00053	T cell activation	P01332	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	IDA	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	TAS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	ARATH|TAIR=AT4G35290|UniProtKB=Q93YT1	Glutamate receptor 3.2	ISS	12871085	PubMed	PTHR43891:SF18	GLUTAMATE RECEPTOR 3.1-RELATED
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	BOVIN|Ensembl=ENSBTAG00000000469|UniProtKB=P67774	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00922	Collagen	MACMU|Ensembl=ENSMMUG00000022317|UniProtKB=F6XD59	Uncharacterized protein	ISS	10778855	PubMed	PTHR44172:SF1	COLLAGEN ALPHA-2 VI  CHAIN
P00049	Parkinson disease	P01211	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05731	GABA-B receptor II signaling	P05755	Gbeta	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	NEUCR|EnsemblGenome=EFNCRG00000003423|UniProtKB=Q1K7Z3	Ubiquitin carboxyl-terminal hydrolase	ISS			PTHR10589:SF16	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00583	cPLA2	MONDO|Ensembl=ENSMODG00000011791|UniProtKB=F7CBU9	Phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P05918	p38 MAPK pathway	P05920	MAPKAP-K2	HUMAN|HGNC=6887|UniProtKB=P49137	MAP kinase-activated protein kinase 2	RCA	10779545	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00048	PI3 kinase pathway	P01192	p110	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00049	Parkinson disease	P01238	14-3-3	ENTHI|EnsemblGenome=EHI_098280|UniProtKB=C4LXB1	14-3-3 protein 2	IDA	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00019	Endothelin signaling pathway	P00572	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00796	Kainate receptor	HUMAN|HGNC=4582|UniProtKB=Q16099	Glutamate receptor ionotropic, kainate 4	IDA	12871085	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00053	T cell activation	P01332	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00047	PDGF signaling pathway	P01152	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00005	Angiogenesis	P00217	STAT3	RAT|RGD=3772|UniProtKB=P52631	Signal transducer and activator of transcription 3	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CANLF|Ensembl=ENSCAFG00000008756|UniProtKB=F2Z4N8	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00012	Cadherin signaling pathway	P00474	Wnt	RAT|RGD=69250|UniProtKB=Q9QXQ7	Protein Wnt-5a	IDA	8717036	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00048	PI3 kinase pathway	P01192	p110	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01202	p85	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00021	FGF signaling pathway	P00633	Ras	CAEEL|WormBase=WBGene00002335|UniProtKB=P22981	Ras protein let-60	IGI	22022015	PubMed	PTHR24070:SF385	GTPASE HRAS
P00036	Interleukin signaling pathway	P00965	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00398	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02738	De novo purine biosynthesis	P02899	GMP synthase	ARATH|TAIR=AT1G63660|UniProtKB=Q9CAD1	At1g63660	ISS			PTHR11922:SF2	GMP SYNTHASE  GLUTAMINE-HYDROLYZING
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00009	Axon guidance mediated by netrin	P00363	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00521	Profilin	CAEEL|WormBase=WBGene00003989|UniProtKB=Q9XW16	Profilin-1	ISS			PTHR11604:SF6	PROFILIN-1
P05913	Enkephalin release	P05977	G-Protein (s)	DANRE|ZFIN=ZDB-GENE-010705-1|UniProtKB=Q90Z40	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00034	Integrin signalling pathway	P00938	Cdc42	TAKRU|Ensembl=ENSTRUG00000008289|UniProtKB=H2T7U8	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF129	CDC42L PROTEIN
P00036	Interleukin signaling pathway	P00983	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00056	VEGF signaling pathway	P01413	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TAKRU|Ensembl=ENSTRUG00000007989|UniProtKB=P68140	Actin, alpha skeletal muscle A	IC	11889139	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00053	T cell activation	P01315	Calcineurin	CANLF|Ensembl=ENSCAFG00000014818|UniProtKB=E2RJ59	Serine/threonine-protein phosphatase	ISS	7532676	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	SCHPO|PomBase=SPAC6G9.11|UniProtKB=Q92356	Synaptobrevin homolog 1	IC			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00004	Alzheimer disease-presenilin pathway	P00137	Tip60	BOVIN|Ensembl=ENSBTAG00000018699|UniProtKB=Q08DP5	Histone acetyltransferase	ISS			PTHR10615:SF102	HISTONE ACETYLTRANSFERASE KAT7
P05913	Enkephalin release	P05976	Enkephalin	MACMU|Ensembl=ENSMMUG00000006775|UniProtKB=F7H3N8	Uncharacterized protein	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	RAT|RGD=2869|UniProtKB=P24062	Insulin-like growth factor 1 receptor	ISS	6754360	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2344|UniProtKB=P08485	Muscarinic acetylcholine receptor M4	IDA	91373358	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00005	Angiogenesis	P00218	STAT1	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	ISS	12461178	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00010	B cell activation	P00374	Lyn	RAT|RGD=621017|UniProtKB=Q07014	Tyrosine-protein kinase Lyn	IDA	1371009	PubMed	PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IGI	10669416	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00048	PI3 kinase pathway	P01182	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	MOUSE|MGI=MGI=99473|UniProtKB=Q8BWG8	Beta-arrestin-1	ISS	9388255	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00057	Wnt signaling pathway	P01457	GBeta	PHYIT|EnsemblGenome=PITG_06376|UniProtKB=D0N4Q3	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta, putative	IDA	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	MOUSE|MGI=MGI=96607|UniProtKB=P05555	Integrin alpha-M	IDA	3487386	PubMed	PTHR23220:SF120	INTEGRIN ALPHA-M
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	HUMAN|HGNC=4584|UniProtKB=Q05586	Glutamate receptor ionotropic, NMDA 1	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IDA	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	RAT|RGD=3380|UniProtKB=P63331	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01167	Ets	MONDO|Ensembl=ENSMODG00000009972|UniProtKB=F7EKJ9	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF15	ETS-RELATED TRANSCRIPTION FACTOR ELF-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ARATH|TAIR=AT5G09810|UniProtKB=P53492	Actin-7	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00048	PI3 kinase pathway	P01185	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00056	VEGF signaling pathway	P01405	VRAP	PANTR|Ensembl=ENSPTRG00000001476|UniProtKB=H2R8K0	Uncharacterized protein	ISS	10692392	PubMed	PTHR14388:SF9	SH2 DOMAIN-CONTAINING PROTEIN 2A
P00012	Cadherin signaling pathway	P00474	Wnt	PANTR|Ensembl=ENSPTRG00000009322|UniProtKB=H2REI3	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF84	PROTEIN WNT-9B
P04393	Ras Pathway	P04558	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05731	GABA-B receptor II signaling	P05754	Ggamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	RCA	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00021	FGF signaling pathway	P00637	MKK4,7	PANTR|Ensembl=ENSPTRG00000008783|UniProtKB=H2QCA7	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00053	T cell activation	P01303	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	12748278	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ORYSJ|EnsemblGenome=OS05G0106600|UniProtKB=Q65XH8	Os05g0106600 protein	IC	11889126	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00006	Apoptosis signaling pathway	P00274	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04542	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=12788|UniProtKB=Q9H1J5	Protein Wnt-8a	TAS	11266476	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P00047	PDGF signaling pathway	P01151	PKB	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	12655147	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_59367|UniProtKB=E9H7Z0	Guanine nucleotide-binding protein G(O) subunit alpha 1	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	DROME|FlyBase=FBgn0000253|UniProtKB=P62152	Calmodulin	ISS	9753452	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00007	Axon guidance mediated by semaphorins	P00340	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00023	General transcription regulation	P00660	RNA Polymerase II	YEAST|SGD=S000001283|UniProtKB=P16370	DNA-directed RNA polymerase II subunit RPB3	ISS	2187864	PubMed	PTHR11800:SF2	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3
P00019	Endothelin signaling pathway	P00589	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IGI	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01155	Jak	XENTR|Xenbase=XB-GENE-483750|UniProtKB=F7DKS0	Tyrosine-protein kinase	ISS	147796	OMIM	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01407	Erk	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00045	Notch signaling pathway	P01105	TACE	HUMAN|HGNC=188|UniProtKB=O14672	Disintegrin and metalloproteinase domain-containing protein 10	ISS			PTHR11905:SF4	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 10
P06664	Gonadotropin-releasing hormone receptor pathway	P06798	PKCe/theta	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	RCA	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CAEBR|Gene=CBG05858|UniProtKB=A8X1H0	Protein CBR-EGL-19 (Fragment)	ISS	15621031	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	TAS			PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000000931|UniProtKB=H2PZC4	Protein kinase N2	ISS	10644715	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00034	Integrin signalling pathway	P00944	Actin	RAT|RGD=1309504|UniProtKB=D3ZRN3	Protein Actbl2	ISS	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	TAS			PTHR10048:SF14	PI-3 KINASE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	BOVIN|Ensembl=ENSBTAG00000013111|UniProtKB=F1MSF1	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00001	Adrenaline and noradrenaline biosynthesis	P00062	TH	TAKRU|Ensembl=ENSTRUG00000009267|UniProtKB=A0JGX6	Tyrosine 3-monooxygenase	ISS	12480184	PubMed	PTHR11473:SF34	TYROSINE HYDROXYLASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	1499560	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00005	Angiogenesis	P00223	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00463	betacatenin	CANLF|Ensembl=ENSCAFG00000005204|UniProtKB=B6V8E6	Catenin beta-1	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05916	Opioid prodynorphin pathway	P06002	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00029	Huntington disease	P00807	Actin	MOUSE|MGI=MGI=87902|UniProtKB=P68134	Actin, alpha skeletal muscle	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00021	FGF signaling pathway	P00623	FGF	CHICK|Ensembl=ENSGALG00000007343|UniProtKB=P19596	Fibroblast growth factor 1	IGI	88296438	PubMed	PTHR11486:SF86	FIBROBLAST GROWTH FACTOR 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05938	RhoA	XENTR|Xenbase=XB-GENE-941426|UniProtKB=Q28HZ4	Novel Rho protein	ISS	11360179	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00029	Huntington disease	P00780	Microtubule	RAT|RGD=1588452|UniProtKB=P85108	Tubulin beta-2A chain	IDA	9454836	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P00007	Axon guidance mediated by semaphorins	P00339	CRMP	MOUSE|MGI=MGI=1349763|UniProtKB=O08553	Dihydropyrimidinase-related protein 2	ISS	7637782	PubMed	PTHR11647:SF56	DIHYDROPYRIMIDINASE-RELATED PROTEIN 2
P00057	Wnt signaling pathway	P01445	Cerebus	HUMAN|HGNC=1862|UniProtKB=O95813	Cerberus	IDA	10067895	PubMed	PTHR15273:SF4	CERBERUS
P02726	Aminobutyrate degradation	P02825	4-aminobutyrate aminotransferase	CAEEL|WormBase=WBGene00001794|UniProtKB=Q21217	Probable 4-aminobutyrate aminotransferase, mitochondrial	ISS	8133261	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MOUSE|MGI=MGI=1202876|UniProtKB=Q9Z1J1	Transcription factor 7-like 1	IEP	11266476	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00005	Angiogenesis	P00211	GSK3beta	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	HUMAN|HGNC=4599|UniProtKB=Q14831	Metabotropic glutamate receptor 7	ISS	12488551	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	MACMU|Ensembl=ENSMMUG00000003707|UniProtKB=F7GDQ6	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF58	ACTIVIN RECEPTOR TYPE-1C
P00059	p53 pathway	P04623	CBP	BOVIN|Ensembl=ENSBTAG00000016198|UniProtKB=E1B8D6	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00049	Parkinson disease	P01219	SAPK	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CHICK|Ensembl=ENSGALG00000001334|UniProtKB=F1NLV4	Uncharacterized protein	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P02772	Pyruvate metabolism	P03141	Citrate Synthetase	MACMU|Ensembl=ENSMMUG00000002483|UniProtKB=F7HGU4	Citrate synthase	ISS	2337600	PubMed	PTHR11739:SF8	CITRATE SYNTHASE, MITOCHONDRIAL
P00029	Huntington disease	P00786	ARF	HUMAN|HGNC=659|UniProtKB=P62330	ADP-ribosylation factor 6	IPI	11752622	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	MOUSE|MGI=MGI=1321159|UniProtKB=P63330	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00931	Integrin beta	PANTR|Ensembl=ENSPTRG00000012571|UniProtKB=H2QIV8	Integrin beta	ISS	3487386	PubMed	PTHR10082:SF11	INTEGRIN BETA-6
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ORYSJ|EnsemblGenome=OS03G0836000|UniProtKB=Q10AZ4	Actin-3	IC	11889126	PubMed	PTHR11937:SF254	ACTIN-1-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MOUSE|MGI=MGI=1336171|UniProtKB=Q9DAS9	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00006	Apoptosis signaling pathway	P00269	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	MONDO|Ensembl=ENSMODG00000013970|UniProtKB=F6R6X5	Uncharacterized protein	ISS	11431030	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00029	Huntington disease	P00796	Kainate receptor	MONDO|Ensembl=ENSMODG00000020977|UniProtKB=F6S5B1	Uncharacterized protein (Fragment)	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00018	EGF receptor signaling pathway	P00562	p38	DROME|FlyBase=FBgn0015765|UniProtKB=O62618	Mitogen-activated protein kinase 14A	IGI	10514528	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	BOVIN|Ensembl=ENSBTAG00000005345|UniProtKB=Q3T035	Actin-related protein 2/3 complex subunit 3	ISS	12473693	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00038	JAK/STAT signaling pathway	P01030	SOCS	BOVIN|Ensembl=ENSBTAG00000004386|UniProtKB=F1MSN0	Suppressor of cytokine signaling 1	ISS			PTHR44621:SF2	SUPPRESSOR OF CYTOKINE SIGNALING 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00560	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00035	Interferon-gamma signaling pathway	P00956	SOCS	HUMAN|HGNC=1984|UniProtKB=Q9NSE2	Cytokine-inducible SH2-containing protein	TAS	15032587	PubMed	PTHR44649:SF1	CYTOKINE-INDUCIBLE SH2-CONTAINING PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00021	FGF signaling pathway	P00640	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	11292874	PubMed	PTHR10048:SF14	PI-3 KINASE
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00059	p53 pathway	P04612	HDAC1	PANTR|Ensembl=ENSPTRG00000039785|UniProtKB=H2RGL2	Histone deacetylase	ISS	12665570	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00193	SOS-1	CHICK|Ensembl=ENSGALG00000013224|UniProtKB=F1NMA4	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	RCA	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01443	Phospholipase C	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IDA	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00017	DNA replication	P00527	Histones	BOVIN|Ensembl=ENSBTAG00000017016|UniProtKB=A5PK61	Histone H3.3C	ISS	20448842	PubMed	PTHR11426:SF179	HISTONE H3.3
P04393	Ras Pathway	P04567	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	IDA	96320556	PubMed	PTHR10048:SF14	PI-3 KINASE
P00036	Interleukin signaling pathway	P00981	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=12776|UniProtKB=O96014	Protein Wnt-11	IDA	8717036	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00038	JAK/STAT signaling pathway	P01027	STAT	CHICK|Ensembl=ENSGALG00000003267|UniProtKB=Q6DV79	Signal transducer and activator of transcription 3	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	RAT|RGD=3238|UniProtKB=P01179	Oxytocin-neurophysin 1	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MOUSE|MGI=MGI=2444552|UniProtKB=Q8BFZ3	Beta-actin-like protein 2	IC	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00048	PI3 kinase pathway	P01177	P110ACT	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00056	VEGF signaling pathway	P01408	Akt/PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05752	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MOUSE|MGI=MGI=98726|UniProtKB=P27090	Transforming growth factor beta-2	TAS	9759503	PubMed	PTHR11848:SF141	TRANSFORMING GROWTH FACTOR BETA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IDA	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05915	Opioid proenkephalin pathway	P05993	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00006	Apoptosis signaling pathway	P00260	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00013	Cell cycle	P00489	CdkC	RAT|RGD=2294|UniProtKB=P39949	G1/S-specific cyclin-E1	RCA			PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00011	Blood coagulation	P00425	ZPI	PANTR|Ensembl=ENSPTRG00000006677|UniProtKB=H2Q8V0	Uncharacterized protein	ISS	7705879	gi	PTHR11461:SF191	PROTEIN Z-DEPENDENT PROTEASE INHIBITOR
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00057	Wnt signaling pathway	P01437	TCF	MACMU|Ensembl=ENSMMUG00000020134|UniProtKB=F6U055	Uncharacterized protein	ISS	11266476	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01407	Erk	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MOUSE|MGI=MGI=1354730|UniProtKB=Q9Z2H2	Regulator of G-protein signaling 6	IDA	8756726	PubMed	PTHR10845:SF27	REGULATOR OF G-PROTEIN SIGNALING 6
P04393	Ras Pathway	P04558	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00054	Toll receptor signaling pathway	P01348	A20	MACMU|Ensembl=ENSMMUG00000008869|UniProtKB=F7DY40	Tumor necrosis factor alpha-induced protein 3	ISS			PTHR13367:SF3	TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 3
P00036	Interleukin signaling pathway	P00970	Interleukin	HUMAN|HGNC=6001|UniProtKB=P60568	Interleukin-2	IC			PTHR45426:SF1	INTERLEUKIN-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DICDI|dictyBase=DDB_G0289487|UniProtKB=P07829	Actin-3	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00006	Apoptosis signaling pathway	P00321	HSP70	HUMAN|HGNC=5238|UniProtKB=P11021	78 kDa glucose-regulated protein	IDA	10934466	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00049	Parkinson disease	P01211	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00018	EGF receptor signaling pathway	P00549	EGF	MOUSE|MGI=MGI=1933833|UniProtKB=Q9WTX4	Pro-neuregulin-4, membrane-bound isoform	RCA			PTHR11100:SF20	PRO-NEUREGULIN-2, MEMBRANE-BOUND ISOFORM-RELATED
P00034	Integrin signalling pathway	P00944	Actin	ORNAN|Ensembl=ENSOANG00000007716|UniProtKB=F6UDX9	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04393	Ras Pathway	P04546	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01150	PKC	RAT|RGD=620146|UniProtKB=O08874	Serine/threonine-protein kinase N2	ISS	125549	gi	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00034	Integrin signalling pathway	P00912	Arp2/3	CAEBR|Gene=CBG04201|UniProtKB=A8WWE8	Actin-related protein 2/3 complex subunit 5	ISS	12473693	PubMed	PTHR12644:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P04393	Ras Pathway	P04567	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04568	MKK3/6	CANLF|Ensembl=ENSCAFG00000018530|UniProtKB=F1PXD3	Uncharacterized protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04393	Ras Pathway	P04546	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IDA	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04393	Ras Pathway	P04558	p38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IDA	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00005	Angiogenesis	P00251	cPLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	IDA	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00865	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	8264585	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P04393	Ras Pathway	P04570	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01082	AC	MOUSE|MGI=MGI=2660854|UniProtKB=Q8C0T9	Adenylate cyclase type 10	IC	9874775	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P00057	Wnt signaling pathway	P01448	CBP	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	IDA	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00021	FGF signaling pathway	P00629	PP2A	HUMAN|HGNC=9303|UniProtKB=P30154	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform	ISS			PTHR10648:SF9	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 65 KDA REGULATORY SUBUNIT A BETA ISOFORM
P00057	Wnt signaling pathway	P01457	GBeta	EMENI|EnsemblGenome=CADANIAG00002670|UniProtKB=Q5BH99	G-protein beta subunit [Source:UniProtKB/TrEMBLAcc:O74214]	IDA	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00052	TGF-beta signaling pathway	P01275	P38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	TAS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DROME|FlyBase=FBgn0000045|UniProtKB=P02574	Actin, larval muscle	ISS	11889126	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	IC	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04674	Mdm2	HUMAN|HGNC=6974|UniProtKB=O15151	Protein Mdm4	ISS			PTHR13844:SF20	PROTEIN MDM4
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	TAS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01336	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	CANLF|Ensembl=ENSCAFG00000017262|UniProtKB=F1PVV7	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF328	MYOSIN-10
P00056	VEGF signaling pathway	P01407	Erk	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=2321|UniProtKB=Q63315	Cadherin-22	IDA	8120095	PubMed	PTHR24027:SF311	CADHERIN-22
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	RCA	91072385	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	XENTR|Xenbase=XB-GENE-977853|UniProtKB=F7EBE7	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	MOUSE|MGI=MGI=99946|UniProtKB=Q61817	Cyclic AMP-responsive element-binding protein 3	RCA			PTHR22952:SF100	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00627	ERK1-2	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00373	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IGI	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P02761	Pantothenate biosynthesis	P03066	Aspartate decarboxylase	THEMA|EnsemblGenome=TM_0939|UniProtKB=Q9X037	Aspartate 1-decarboxylase	ISS			PTHR21012:SF0	ASPARTATE 1-DECARBOXYLASE
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00053	T cell activation	P01322	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00206	Wnt	MOUSE|MGI=MGI=108061|UniProtKB=P48614	Protein Wnt-10b	ISS	12549854	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	PANTR|Ensembl=ENSPTRG00000010386|UniProtKB=H2QF61	Tyrosine-protein kinase receptor	ISS	2983222	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00034	Integrin signalling pathway	P00907	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00590	IP3 R	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	IGI	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	PANTR|Ensembl=ENSPTRG00000009085|UniProtKB=H2RDQ2	Uncharacterized protein	ISS	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	CANLF|Ensembl=ENSCAFG00000015094|UniProtKB=F1PT97	Uncharacterized protein	ISS	12473693	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	RAT|RGD=1306312|UniProtKB=D4A9D7	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	HUMAN|HGNC=12372|UniProtKB=P01222	Thyrotropin subunit beta	ISS	3017658	PubMed	PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Gene=CHRM3|UniProtKB=Q9N2A4	Muscarinic acetylcholine receptor M3	IDA			PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00054	Toll receptor signaling pathway	P01352	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00055	Transcription regulation by bZIP transcription factor	P01395	TFIIE	HUMAN|HGNC=4650|UniProtKB=P29083	General transcription factor IIE subunit 1	ISS	189962	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00006	Apoptosis signaling pathway	P00274	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	MOUSE|MGI=MGI=99473|UniProtKB=Q8BWG8	Beta-arrestin-1	ISS	11742073	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00047	PDGF signaling pathway	P01153	GSK3	CANLF|Ensembl=ENSCAFG00000004882|UniProtKB=F1PAE3	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00047	PDGF signaling pathway	P01153	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00049	Parkinson disease	P01238	14-3-3	XENTR|Xenbase=XB-GENE-949031|UniProtKB=Q28DR3	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	ISS	10407019	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P06664	Gonadotropin-releasing hormone receptor pathway	P06849	Sos	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	RCA	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	PANTR|Ensembl=ENSPTRG00000007489|UniProtKB=H2QA49	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00029	Huntington disease	P00807	Actin	BOVIN|Gene=ACTB|UniProtKB=P60712	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	ORNAN|Ensembl=ENSOANG00000005134|UniProtKB=F6WFN3	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF335	MYOSIN-11
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00048	PI3 kinase pathway	P01181	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00059	p53 pathway	G01571	FAS	RAT|RGD=619831|UniProtKB=Q63199	Tumor necrosis factor receptor superfamily member 6	IGI	14585074	PubMed	PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P00047	PDGF signaling pathway	P01155	Jak	PANTR|Ensembl=ENSPTRG00000000825|UniProtKB=H2PZ66	Tyrosine-protein kinase	ISS	11929133	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	HUMAN|HGNC=5183|UniProtKB=P25021	Histamine H2 receptor	IDA	11841575	PubMed	PTHR43893:SF5	HISTAMINE H2 RECEPTOR
P00057	Wnt signaling pathway	P01430	p53	PANTR|Ensembl=ENSPTRG00000008703|UniProtKB=H2QC53	Cellular tumor antigen p53	ISS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CAEEL|WormBase=WBGene00004038|UniProtKB=Q22070	Phosphoinositide phospholipase C	ISS			PTHR10336:SF91	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00006	Apoptosis signaling pathway	P00297	NFkappaB	PANTR|Ensembl=ENSPTRG00000011133|UniProtKB=H2QGK5	Uncharacterized protein	ISS			PTHR24169:SF18	TRANSCRIPTION FACTOR RELB
P04397	p53 pathway by glucose deprivation	P04639	AMPK	HUMAN|HGNC=9379|UniProtKB=O43741	5'-AMP-activated protein kinase subunit beta-2	ISS			PTHR10343:SF45	5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2
P02738	De novo purine biosynthesis	P02909	GDP reductase	EMENI|EnsemblGenome=CADANIAG00002685|UniProtKB=Q5BHB3	Ribonucleotide reductase [Source:UniProtKB/TrEMBLAcc:Q9HEW8]	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00046	Oxidative stress response	P01129	JNK1/2	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00059	p53 pathway	G04703	Apaf	HUMAN|HGNC=576|UniProtKB=O14727	Apoptotic protease-activating factor 1	IDA	14526190	PubMed	PTHR22845:SF5	APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
P04393	Ras Pathway	P04572	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	IC	88234494	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04658	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	SCHPO|PomBase=SPBC32H8.07|UniProtKB=Q10282	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MOUSE|MGI=MGI=1921305|UniProtKB=Q8K4S1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	7822322	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00021	FGF signaling pathway	P00629	PP2A	MONDO|Ensembl=ENSMODG00000019001|UniProtKB=F7CP86	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02917	Ribonucleoside triphosphate Reductase	FUSNN|EnsemblGenome=FN0311|UniProtKB=Q8RGI2	Anaerobic ribonucleoside-triphosphate reductase	ISS			PTHR21075:SF0	ANAEROBIC RIBONUCLEOSIDE-TRIPHOSPHATE REDUCTASE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	IC	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	ARATH|TAIR=AT5G63310|UniProtKB=O64903	Nucleoside diphosphate kinase II, chloroplastic	ISS			PTHR11349:SF44	NUCLEOSIDE DIPHOSPHATE KINASE II, CHLOROPLASTIC
P00021	FGF signaling pathway	P00645	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00012	Cadherin signaling pathway	P00475	Frizzled	DANRE|ZFIN=ZDB-GENE-000328-4|UniProtKB=B0S6S2	Uncharacterized protein	IDA	8717036	PubMed	PTHR11309:SF90	FRIZZLED-8
P00005	Angiogenesis	P00203	Erk	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00627	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	11204774	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00029	Huntington disease	P00807	Actin	NEUCR|EnsemblGenome=EFNCRG00000003893|UniProtKB=P78711	Actin	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00005	Angiogenesis	P00209	FAK	HUMAN|HGNC=9611|UniProtKB=Q05397	Focal adhesion kinase 1	IDA	12640026	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00057	Wnt signaling pathway	P01444	Wnt	MACMU|Ensembl=ENSMMUG00000006621|UniProtKB=F7HKD3	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00029	Huntington disease	P00807	Actin	IXOSC|EnsemblGenome=ISCW024111|UniProtKB=B7PBG2	Actin, putative (Fragment)	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00053	T cell activation	P01332	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00570	PKA	DROME|FlyBase=FBgn0000489|UniProtKB=P16912	Protein kinase DC2	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	TAS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00047	PDGF signaling pathway	P01162	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IC	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00005	Angiogenesis	P00251	cPLA2	CHICK|Ensembl=ENSGALG00000005065|UniProtKB=P49147	Cytosolic phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P02738	De novo purine biosynthesis	P02889	dGDP kinase	DROME|FlyBase=FBgn0000150|UniProtKB=P08879	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01435	SWI/SNF	YEAST|SGD=S000003118|UniProtKB=P53115	Putative DNA helicase INO80	IDA	11532957	PubMed	PTHR10799:SF868	DNA HELICASE INO80
P00053	T cell activation	P01314	nck	MACMU|Ensembl=ENSMMUG00000007389|UniProtKB=F7E0A3	Cytoplasmic protein NCK1 isoform 1	ISS	11689432	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P00047	PDGF signaling pathway	P01140	ELK	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	ISS	3183861	gi	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00029	Huntington disease	P00778	NMDA receptor	CHICK|Ensembl=ENSGALG00000008898|UniProtKB=F1P2J9	Uncharacterized protein	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=109356|UniProtKB=O09044	Synaptosomal-associated protein 23	IC	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01428	Frizzled	MOUSE|MGI=MGI=1888513|UniProtKB=Q9JIP6	Frizzled-2	IDA	8717036	PubMed	PTHR11309:SF34	FRIZZLED-2
P00029	Huntington disease	P00785	Cytochrome c	YEAST|SGD=S000005591|UniProtKB=P07143	Cytochrome c1, heme protein, mitochondrial	IDA	9027315	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00019	Endothelin signaling pathway	P00568	PKC	DANRE|ZFIN=ZDB-GENE-040426-1178|UniProtKB=Q7SY24	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00049	Parkinson disease	P01212	p38 MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01153	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00047	PDGF signaling pathway	P01160	IP3 receptor	ANOGA|EnsemblGenome=AGAP006475|UniProtKB=Q5TQX0	AGAP006475-PA	ISS	12880387	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00021	FGF signaling pathway	P00645	Rac	CAEEL|WormBase=WBGene00004287|UniProtKB=Q94124	Ras-related protein rac-2	IGI	12932731	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00059	p53 pathway	G01563	MDM-2	MOUSE|MGI=MGI=96952|UniProtKB=P23804	E3 ubiquitin-protein ligase Mdm2	IGI	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00047	PDGF signaling pathway	P01171	PLCgamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	BOVIN|Ensembl=ENSBTAG00000001725|UniProtKB=Q2KIQ8	C-X-C motif chemokine 10	ISS	10946576	gi	PTHR10179:SF47	C-X-C MOTIF CHEMOKINE 10
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	MACMU|Ensembl=ENSMMUG00000020765|UniProtKB=F7HEG5	Ribonucleoside-diphosphate reductase subunit M2 B	ISS			PTHR23409:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 B
P00004	Alzheimer disease-presenilin pathway	P00118	E-cadherin	MOUSE|MGI=MGI=88356|UniProtKB=P10287	Cadherin-3	IDA	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P00047	PDGF signaling pathway	P01154	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00059	p53 pathway	P04630	PP2A	MACMU|Ensembl=ENSMMUG00000013047|UniProtKB=F7H808	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=1308760|UniProtKB=F2Z3R5	Protein Pcdhb1	ISS	8120095	PubMed	PTHR24028:SF12	PROTOCADHERIN BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	XENTR|Xenbase=XB-GENE-491938|UniProtKB=Q6DIV8	Actin, alpha 1, skeletal muscle	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P06664	Gonadotropin-releasing hormone receptor pathway	P06831	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	RCA	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IDA	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00045	Notch signaling pathway	P01112	CoR	MOUSE|MGI=MGI=1337080|UniProtKB=Q9WU42	Nuclear receptor corepressor 2	TAS	11112321	PubMed	PTHR13992:SF21	NUCLEAR RECEPTOR COREPRESSOR 2
P05913	Enkephalin release	P05972	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04397	p53 pathway by glucose deprivation	P04641	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	CHICK|Ensembl=ENSGALG00000010772|UniProtKB=F1P0L1	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF26	REGULATOR OF G-PROTEIN SIGNALING 7
P00034	Integrin signalling pathway	P00925	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P05918	p38 MAPK pathway	P06025	SRF	BOVIN|Ensembl=ENSBTAG00000012777|UniProtKB=E1BJP4	Uncharacterized protein	ISS	8660892	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	BOVIN|Ensembl=ENSBTAG00000000219|UniProtKB=F1MCL3	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000015241|UniProtKB=Q5IS72	D(3) dopamine receptor	ISS	11861492	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00018	EGF receptor signaling pathway	P00556	PLCgamma	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00056	VEGF signaling pathway	P01415	MAPKAPK2/3	ORNAN|Ensembl=ENSOANG00000007737|UniProtKB=F6PX17	Uncharacterized protein	ISS			PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	RAT|RGD=2246|UniProtKB=Q07652	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	8386525	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00021	FGF signaling pathway	P00629	PP2A	RAT|RGD=3381|UniProtKB=P62716	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05731	GABA-B receptor II signaling	P05755	Gbeta	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00005	Angiogenesis	P00227	PLA2	CANLF|Ensembl=ENSCAFG00000013778|UniProtKB=F6UQ33	Phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P02769	Purine metabolism	P03116	Xanthine Oxidase	HUMAN|HGNC=12805|UniProtKB=P47989	Xanthine dehydrogenase/oxidase	ISS	4336760	gi	PTHR11908:SF80	XANTHINE DEHYDROGENASE/OXIDASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	2837282	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P05915	Opioid proenkephalin pathway	P05994	G-protein	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_126324|UniProtKB=C3XYC2	Putative uncharacterized protein	IDA	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	ORYSJ|EnsemblGenome=OS01G0267900|UniProtKB=Q0JNS6	Calmodulin-1	ISS	7514101	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00010	B cell activation	P00376	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00049	Parkinson disease	P01219	SAPK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	CAEEL|WormBase=WBGene00002202|UniProtKB=P42168	Casein kinase I isoform alpha	ISS	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00057	Wnt signaling pathway	P01438	PP2A	DANRE|ZFIN=ZDB-GENE-050417-441|UniProtKB=Q567Y8	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04628	14-3-3	ORNAN|Ensembl=ENSOANG00000006084|UniProtKB=F7BU66	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF14	14-3-3 PROTEIN SIGMA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00920	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00054	Toll receptor signaling pathway	P01361	TBK1	MACMU|Ensembl=ENSMMUG00000007658|UniProtKB=F7DBZ3	Serine/threonine-protein kinase TBK1	ISS			PTHR22969:SF14	SERINE/THREONINE-PROTEIN KINASE TBK1
P00060	Ubiquitin proteasome pathway	P01490	E3	RAT|RGD=1311734|UniProtKB=Q4V8H7	E3 ubiquitin-protein ligase	ISS			PTHR11254:SF299	NEDD4-LIKE E3 UBIQUITIN-PROTEIN LIGASE WWP1
P00056	VEGF signaling pathway	P01408	Akt/PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00005	Angiogenesis	P00203	Erk	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01430	p53	MOUSE|MGI=MGI=98834|UniProtKB=P02340	Cellular tumor antigen p53	IDA	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00005	Angiogenesis	P00206	Wnt	DANRE|ZFIN=ZDB-GENE-980526-526|UniProtKB=P24257	Protein Wnt-1	ISS	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00038	JAK/STAT signaling pathway	P01027	STAT	HUMAN|HGNC=11368|UniProtKB=P42226	Signal transducer and activator of transcription 6	ISS	8085155	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00029	Huntington disease	P00777	CBP	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00029	Huntington disease	P00807	Actin	MONBE|Gene=37852|UniProtKB=A9V489	Predicted protein	IDA	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	DANRE|ZFIN=ZDB-GENE-000329-3|UniProtKB=Q7ZVF9	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00060	Ubiquitin proteasome pathway	P01490	E3	MOUSE|MGI=MGI=105098|UniProtKB=O08759	Ubiquitin-protein ligase E3A	ISS			PTHR11254:SF301	UBIQUITIN-PROTEIN LIGASE E3A
P04398	p53 pathway feedback loops 2	P04657	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01154	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00041	Metabotropic glutamate receptor group I pathway	P01062	mGluR1	CHICK|Ensembl=ENSGALG00000017238|UniProtKB=F1NWG3	Uncharacterized protein	ISS			PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	MOUSE|MGI=MGI=88276|UniProtKB=Q02248	Catenin beta-1	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	HUMAN|HGNC=11589|UniProtKB=P62380	TATA box-binding protein-like protein 1	ISS	600075	OMIM	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	MOUSE|MGI=MGI=104633|UniProtKB=Q62441	Transducin-like enhancer protein 4	IDA	9783586	PubMed	PTHR10814:SF21	TRANSDUCIN-LIKE ENHANCER PROTEIN 4
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P02746	Heme biosynthesis	P02970	Coproporphyrinogen oxidase (oxygen independent)	FUSNN|EnsemblGenome=FN0560|UniProtKB=Q8R695	Oxygen-independent coproporphyrinogen III oxidase	ISS			PTHR13932:SF5	OXYGEN-INDEPENDENT COPROPORPHYRINOGEN-III OXIDASE-LIKE PROTEIN YGGW
P02775	Salvage pyrimidine ribonucleotides	P03156	CDP kinase	BACSU|EnsemblGenome=BSU27330|UniProtKB=O32033	Uridine kinase	ISS			PTHR10285:SF6	ATP-DEPENDENT KINASE TDA10-RELATED
P04393	Ras Pathway	P04566	Stat 1/3	CHICK|Ensembl=ENSGALG00000003267|UniProtKB=Q6DV79	Signal transducer and activator of transcription 3	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00029	Huntington disease	P00801	Fos protein	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	TAS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MACMU|Ensembl=ENSMMUG00000007765|UniProtKB=F7CW57	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PANTR|Ensembl=ENSPTRG00000002086|UniProtKB=H2Q1A9	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00021	FGF signaling pathway	P00630	RKIP	ANOGA|EnsemblGenome=AGAP002049|UniProtKB=Q380S1	AGAP002049-PA	ISS			PTHR11362:SF28	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	XENTR|Xenbase=XB-GENE-967585|UniProtKB=Q28BZ0	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P05915	Opioid proenkephalin pathway	P05994	G-protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IDA	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CANLF|Ensembl=ENSCAFG00000013148|UniProtKB=Q5R1P3	Glutamate receptor ionotropic, NMDA 2B	IC	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	IDA	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00053	T cell activation	P01332	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01465	Ggamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IDA	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00047	PDGF signaling pathway	P01168	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	14505573	PubMed	PTHR10048:SF14	PI-3 KINASE
P00029	Huntington disease	P00799	JNK-2	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00036	Interleukin signaling pathway	P00964	p90RSK	MACMU|Ensembl=ENSMMUG00000022111|UniProtKB=F7H7W3	Ribosomal protein S6 kinase	ISS	2779569	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P02743	Formyltetrahydroformate biosynthesis	P02952	Methylene tetrahydrofolate dehydrogenase	ARATH|TAIR=AT4G00620|UniProtKB=O65271	Bifunctional protein FolD 4, chloroplastic	ISS			PTHR10025:SF46	BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, MITOCHONDRIAL
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00017	DNA replication	P00533	Pol delta	ORYSJ|EnsemblGenome=OS11G0186400|UniProtKB=Q9LRE6	DNA polymerase delta catalytic subunit	NAS	13124219	gi	PTHR10322:SF23	DNA POLYMERASE DELTA CATALYTIC SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	RAT|RGD=3425|UniProtKB=P97887	Presenilin-1	TAS	12736250	PubMed	PTHR10202:SF18	PRESENILIN-1
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	PANTR|Ensembl=ENSPTRG00000008771|UniProtKB=H2QCA0	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF484	MYOSIN-1
P00034	Integrin signalling pathway	P00951	Jnk	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P06587	Nicotine pharmacodynamics pathway	P06595	CHRNA3	MOUSE|MGI=MGI=87887|UniProtKB=Q8R4G9	Neuronal acetylcholine receptor subunit alpha-3	ISS	18005395	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00238	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IDA	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	90172230	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01159	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MOUSE|MGI=MGI=1921305|UniProtKB=Q8K4S1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	15611108	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MOUSE|MGI=MGI=1201402|UniProtKB=P56484	C-C chemokine receptor type 8	TAS	11238588	PubMed	PTHR10489:SF627	C-C CHEMOKINE RECEPTOR TYPE 8
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00243	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01395	TFIIE	SCHPO|PomBase=SPCC1672.08c|UniProtKB=P79011	Transcription initiation factor IIE subunit beta	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P05916	Opioid prodynorphin pathway	P06002	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=102705|UniProtKB=P63213	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	MACMU|Ensembl=ENSMMUG00000000289|UniProtKB=F7A9T0	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MONDO|Ensembl=ENSMODG00000004799|UniProtKB=F6VM87	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00047	PDGF signaling pathway	P01153	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05915	Opioid proenkephalin pathway	P05989	leu-Enkephalin	MACMU|Ensembl=ENSMMUG00000006775|UniProtKB=F7H3N8	Uncharacterized protein	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00047	PDGF signaling pathway	P01154	Ras	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00005	Angiogenesis	P00227	PLA2	MACMU|Ensembl=ENSMMUG00000021423|UniProtKB=F7EEZ1	Phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00037	Ionotropic glutamate receptor pathway	P01026	KA	RAT|RGD=2734|UniProtKB=Q01812	Glutamate receptor ionotropic, kainate 4	ISS	12871085	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00030	Hypoxia response via HIF activation	P00819	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01142	p90RSK	ORNAN|Ensembl=ENSOANG00000010658|UniProtKB=F6V2V1	Uncharacterized protein	ISS	6755374	gi	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DANRE|ZFIN=ZDB-GENE-040426-1354|UniProtKB=Q7T2C5	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00048	PI3 kinase pathway	P01192	p110	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01428	Frizzled	MOUSE|MGI=MGI=2136761|UniProtKB=Q8BKG4	Frizzled-10	ISS	11212302	PubMed	PTHR11309:SF86	FRIZZLED-10
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IDA	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00057	Wnt signaling pathway	P01448	CBP	BOVIN|Ensembl=ENSBTAG00000016198|UniProtKB=E1B8D6	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00012	Cadherin signaling pathway	P00470	F-actin	PANTR|Ensembl=ENSPTRG00000006890|UniProtKB=H2Q943	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00036	Interleukin signaling pathway	P00990	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01227	20S proteasome	XENTR|Xenbase=XB-GENE-974596|UniProtKB=F6PMD9	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF40	PROTEASOME SUBUNIT ALPHA TYPE-7
P00024	Glycolysis	P00676	Glyceraldehyde 3-phosphate dehydrogenase	CAEEL|WormBase=WBGene00001683|UniProtKB=P04970	Glyceraldehyde-3-phosphate dehydrogenase 1	RCA			PTHR10836:SF65	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE 1-RELATED
P00057	Wnt signaling pathway	P01444	Wnt	CANLF|Ensembl=ENSCAFG00000032632|UniProtKB=J9P2Q5	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	IC	12488551	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00059	p53 pathway	P04617	WRN	MACMU|Ensembl=ENSMMUG00000022655|UniProtKB=F7FM29	Uncharacterized protein	ISS			PTHR13710:SF120	WERNER SYNDROME ATP-DEPENDENT HELICASE
P00057	Wnt signaling pathway	P01435	SWI/SNF	CHICK|Ensembl=ENSGALG00000008553|UniProtKB=F1NYY9	Uncharacterized protein	ISS	11532957	PubMed	PTHR10799:SF868	DNA HELICASE INO80
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	CHICK|Ensembl=ENSGALG00000003806|UniProtKB=O93467	GTP-binding protein	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	RAT|RGD=2742|UniProtKB=P23385	Metabotropic glutamate receptor 1	IDA	9407094	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P05918	p38 MAPK pathway	P06038	TRAF6	HUMAN|HGNC=12036|UniProtKB=Q9Y4K3	TNF receptor-associated factor 6	RCA			PTHR10131:SF111	TNF RECEPTOR-ASSOCIATED FACTOR 6
P00047	PDGF signaling pathway	P01143	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01435	SWI/SNF	HUMAN|HGNC=11101|UniProtKB=O60264	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5	IDA	11532957	PubMed	PTHR10799:SF887	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00641	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	DROME|FlyBase=FBgn0020412|UniProtKB=Q9V3I5	Chromosomal serine/threonine-protein kinase JIL-1	ISS			PTHR24351:SF175	CHROMOSOMAL SERINE/THREONINE-PROTEIN KINASE JIL-1
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	IC	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00018	EGF receptor signaling pathway	P00563	Gab	BOVIN|Ensembl=ENSBTAG00000002813|UniProtKB=A6QLU3	GRB2-associated-binding protein 1	ISS	12584127	gi	PTHR12156:SF18	GRB2-ASSOCIATED-BINDING PROTEIN 1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02927	Dihydrooratate oxidase	SCHPO|PomBase=SPAC57A10.12c|UniProtKB=P32747	Dihydroorotate dehydrogenase (quinone), mitochondrial	ISS			PTHR43517:SF1	DIHYDROOROTATE DEHYDROGENASE  QUINONE , MITOCHONDRIAL
P00007	Axon guidance mediated by semaphorins	P00330	CRAM	CANLF|Ensembl=ENSCAFG00000023265|UniProtKB=F1PK01	Uncharacterized protein	ISS	11034345	PubMed	PTHR11647:SF58	DIHYDROPYRIMIDINASE-RELATED PROTEIN 5
P00005	Angiogenesis	P00251	cPLA2	MONDO|Ensembl=ENSMODG00000011791|UniProtKB=F7CBU9	Phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	MONDO|Ensembl=ENSMODG00000011796|UniProtKB=F7CBS8	Uncharacterized protein (Fragment)	ISS			PTHR10937:SF2	GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE  ISOMERIZING  1
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	BACSU|EnsemblGenome=BSU31060|UniProtKB=P71016	Betaine aldehyde dehydrogenase	IC			PTHR43860:SF2	BETAINE ALDEHYDE DEHYDROGENASE 1, CHLOROPLASTIC-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	XENTR|Xenbase=XB-GENE-967585|UniProtKB=Q28BZ0	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00759	PDEalphabeta	PANTR|Ensembl=ENSPTRG00000017404|UniProtKB=H2QRS2	Phosphodiesterase	ISS	P27664	SPACC	PTHR11347:SF115	ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA
P04393	Ras Pathway	P04570	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00034	Integrin signalling pathway	P00948	Rho	RAT|RGD=1306338|UniProtKB=Q5FVG9	Protein Rnd1	ISS	11973360	PubMed	PTHR24072:SF23	RHO-RELATED GTP-BINDING PROTEIN RHO6
P00057	Wnt signaling pathway	P01428	Frizzled	XENTR|Xenbase=XB-GENE-478210|UniProtKB=F6V5F4	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF23	FRIZZLED-4
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DAPPU|EnsemblGenome=DAPPUDRAFT_228751|UniProtKB=E9HGF5	Cytoplasmatic actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02723	Adenine and hypoxanthine salvage pathway	P02808	Deoxyadenosine phosphorylase	CAEEL|WormBase=WBGene00019298|UniProtKB=U4PSA1	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	TAS	12089061	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00038	JAK/STAT signaling pathway	P01034	Jak	RAT|RGD=2939|UniProtKB=Q62689	Tyrosine-protein kinase JAK2	ISS	12686512	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00059	p53 pathway	P04623	CBP	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	IDA	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P06959	CCKR signaling map	G07270	PAI2	HUMAN|HGNC=8584|UniProtKB=P05120	Plasminogen activator inhibitor 2	RCA	19074642	PubMed	PTHR11461:SF61	PLASMINOGEN ACTIVATOR INHIBITOR 2
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01160	IP3 receptor	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	PANTR|Ensembl=ENSPTRG00000004893|UniProtKB=H2Q5U4	Protein Wnt	ISS	14644163	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	15210700	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	ORNAN|Ensembl=ENSOANG00000000818|UniProtKB=F6PLI7	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00303	c-Jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00050	Plasminogen activating cascade	P01250	MMP-13	RAT|RGD=631408|UniProtKB=O88766	Neutrophil collagenase	ISS	12834808	PubMed	PTHR10201:SF137	NEUTROPHIL COLLAGENASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000009594|UniProtKB=G2HFH4	Somatostatin receptor type 2	ISS	12562507	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DANRE|ZFIN=ZDB-GENE-040426-1178|UniProtKB=Q7SY24	Protein kinase C beta type	ISS	11880265	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MOUSE|MGI=MGI=87906|UniProtKB=P63260	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IDA	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00034	Integrin signalling pathway	P00920	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00054	Toll receptor signaling pathway	P01381	Ubc13	TAKRU|Ensembl=ENSTRUG00000016580|UniProtKB=H2UZL2	Uncharacterized protein	ISS			PTHR43902:SF2	UBIQUITIN-CONJUGATING ENZYME E2 N
P00049	Parkinson disease	P01227	20S proteasome	ORNAN|Ensembl=ENSOANG00000006654|UniProtKB=F6XAZ1	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF12	PROTEASOME SUBUNIT ALPHA TYPE-RELATED
P00059	p53 pathway	P01480	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P02738	De novo purine biosynthesis	P02891	GDP kinase	RAT|RGD=619877|UniProtKB=P19804	Nucleoside diphosphate kinase B	ISS			PTHR11349:SF57	NUCLEOSIDE DIPHOSPHATE KINASE B
P00036	Interleukin signaling pathway	P00996	STAT	RAT|RGD=3774|UniProtKB=P52632	Signal transducer and activator of transcription 5B	IC	96102059	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	RAT|RGD=2062|UniProtKB=P26817	Beta-adrenergic receptor kinase 1	IDA	10852916	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MACMU|Ensembl=ENSMMUG00000010266|UniProtKB=F6PV18	Uncharacterized protein	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00006	Apoptosis signaling pathway	P00318	PKCs	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IDA	10644715	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00047	PDGF signaling pathway	P01167	Ets	MACMU|Ensembl=ENSMMUG00000020706|UniProtKB=F6PU72	Uncharacterized protein	ISS	15579511	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00030	Hypoxia response via HIF activation	P00819	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00049	Parkinson disease	P01207	PLD2	BOVIN|Gene=PLD2|UniProtKB=Q0V8L6	Phospholipase D2	ISS	9538008	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00055	Transcription regulation by bZIP transcription factor	P01390	TFIIA complex	PANTR|Ensembl=ENSPTRG00000007129|UniProtKB=H2Q9J2	Transcription initiation factor IIA subunit 2	ISS	95241493	PubMed	PTHR10966:SF0	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2
P02771	Pyrimidine Metabolism	P03128	Dihydrouracil Dehydrogenase	HUMAN|HGNC=3012|UniProtKB=Q12882	Dihydropyrimidine dehydrogenase [NADP(+)]	TAS	8083224	PubMed	PTHR43073:SF2	DIHYDROPYRIMIDINE DEHYDROGENASE  NADP +
P00029	Huntington disease	P00807	Actin	CHICK|Gene=ACTG2|UniProtKB=P63270	Actin, gamma-enteric smooth muscle	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P05913	Enkephalin release	P05977	G-Protein (s)	MOUSE|MGI=MGI=101848|UniProtKB=P62881	Guanine nucleotide-binding protein subunit beta-5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00029	Huntington disease	P00807	Actin	CRYNJ|EnsemblGenome=CNA04650|UniProtKB=Q5KP06	Actin	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00053	T cell activation	P01332	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05915	Opioid proenkephalin pathway	P05994	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	CAEEL|WormBase=WBGene00003774|UniProtKB=G5EGQ9	NMDA class glutamate Receptor	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	ENTHI|EnsemblGenome=EHI_135470|UniProtKB=C4M9S5	Adenylate kinase	ISS			PTHR23359:SF117	ADENYLATE KINASE 2, MITOCHONDRIAL
P00049	Parkinson disease	P01230	Src kinase	MONDO|Ensembl=ENSMODG00000017905|UniProtKB=F7FG65	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00021	FGF signaling pathway	P00632	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02746	Heme biosynthesis	P02975	Uroporphyrinogen decarboxylase	HUMAN|HGNC=12591|UniProtKB=P06132	Uroporphyrinogen decarboxylase	ISS			PTHR21091:SF2	UROPORPHYRINOGEN DECARBOXYLASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000015640|UniProtKB=E2QVF3	Uncharacterized protein	ISS	8444355	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P02738	De novo purine biosynthesis	P02901	Adenosuccinate lyase	PSEAE|EnsemblGenome=PA3516|UniProtKB=Q9HY93	Probable lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P04398	p53 pathway feedback loops 2	P04657	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00057	Wnt signaling pathway	P01428	Frizzled	HUMAN|HGNC=4044|UniProtKB=O60353	Frizzled-6	IDA	11212302	PubMed	PTHR11309:SF75	FRIZZLED-6
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	PANTR|Ensembl=ENSPTRG00000012554|UniProtKB=H2QIU8	Receptor protein serine/threonine kinase	ISS	10683140	PubMed	PTHR23255:SF58	ACTIVIN RECEPTOR TYPE-1C
P00018	EGF receptor signaling pathway	P00560	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=69426|UniProtKB=P34975	Kappa-type opioid receptor	IDA	11259498	PubMed	PTHR24229:SF1	KAPPA-TYPE OPIOID RECEPTOR
P00034	Integrin signalling pathway	P00907	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	9836512	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00053	T cell activation	P01332	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00005	Angiogenesis	P00210	eNOS	PANTR|Ensembl=ENSPTRG00000019868|UniProtKB=H2QVM2	Nitric oxide synthase	ISS	22462730	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P05915	Opioid proenkephalin pathway	P05994	G-protein	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00025	Hedgehog signaling pathway	P00692	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05917	Opioid proopiomelanocortin pathway	P06011	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00896	Insulin IGF	RAT|RGD=2868|UniProtKB=P08025	Insulin-like growth factor I	ISS			PTHR11454:SF4	INSULIN-LIKE GROWTH FACTOR I
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04397	p53 pathway by glucose deprivation	P04641	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00012	Cadherin signaling pathway	P00466	EGFR	RAT|RGD=620486|UniProtKB=Q62956	Receptor tyrosine-protein kinase erbB-4	ISS	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00018	EGF receptor signaling pathway	P00541	Spry	DANRE|ZFIN=ZDB-GENE-030131-7038|UniProtKB=F1QU39	Uncharacterized protein	ISS			PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P00012	Cadherin signaling pathway	P00474	Wnt	CANLF|Ensembl=ENSCAFG00000014987|UniProtKB=E2RH98	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00778	NMDA receptor	HUMAN|HGNC=4588|UniProtKB=O15399	Glutamate receptor ionotropic, NMDA 2D	IDA	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2D.html	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	DROME|FlyBase=FBgn0039943|UniProtKB=Q9W5Q1	RE68879p	ISS			PTHR23308:SF36	SMAD NUCLEAR-INTERACTING PROTEIN 1
P00001	Adrenaline and noradrenaline biosynthesis	P00061	PNMT	PANTR|Ensembl=ENSPTRG00000004303|UniProtKB=H2Q4T3	Uncharacterized protein	ISS			PTHR10867:SF5	NICOTINAMIDE N-METHYLTRANSFERASE
P05915	Opioid proenkephalin pathway	P05985	Mu or Delta receptor	RAT|RGD=3234|UniProtKB=P33535	Mu-type opioid receptor	RCA	11259498	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MOUSE|MGI=MGI=95822|UniProtKB=Q01098	Glutamate receptor ionotropic, NMDA 2C	IC	11319238	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00047	PDGF signaling pathway	P01148	Grb2	RAT|RGD=621367|UniProtKB=Q9EQH1	GRB2-associated-binding protein 2	ISS			PTHR12156:SF4	GRB2-ASSOCIATED-BINDING PROTEIN 2
P00021	FGF signaling pathway	P00631	Grb2	BOVIN|Ensembl=ENSBTAG00000003707|UniProtKB=A6QLK6	GRB2-related adapter protein	ISS	51702266	gi	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00046	Oxidative stress response	P01135	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00021	FGF signaling pathway	P00632	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00174	CD44 N-terminal fragment	HUMAN|HGNC=1681|UniProtKB=P16070	CD44 antigen	IDA	12223485	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=97614|UniProtKB=Q8R3B1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	TAS			PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	RAT|RGD=3187|UniProtKB=Q07008	Neurogenic locus notch homolog protein 1	IDA	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00046	Oxidative stress response	P01134	cPLA2	CANLF|Ensembl=ENSCAFG00000013778|UniProtKB=F6UQ33	Phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	HUMAN|HGNC=6266|UniProtKB=P48544	G protein-activated inward rectifier potassium channel 4	IDA	2433589	PubMed	PTHR11767:SF52	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 4
P00054	Toll receptor signaling pathway	P01368	MKK2	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IDA	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00046	Oxidative stress response	P01129	JNK1/2	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00012	Cadherin signaling pathway	P00475	Frizzled	DROME|FlyBase=FBgn0016797|UniProtKB=Q9VVX3	Frizzled-2	IDA	11212302	PubMed	PTHR11309:SF90	FRIZZLED-8
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000006495|UniProtKB=P11017	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00021	FGF signaling pathway	P00629	PP2A	BRAFL|Gene=BRAFLDRAFT_123893|UniProtKB=C3XQF4	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	PANTR|Ensembl=ENSPTRG00000013189|UniProtKB=H2QJV1	Uncharacterized protein	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	PANTR|Ensembl=ENSPTRG00000022064|UniProtKB=H2QYE0	Uncharacterized protein	ISS	15632195	PubMed	PTHR24351:SF98	RIBOSOMAL PROTEIN S6 KINASE ALPHA-6
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00034	Integrin signalling pathway	P00907	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01276	Co-Smads	MOUSE|MGI=MGI=894293|UniProtKB=P97471	Mothers against decapentaplegic homolog 4	TAS	9395284	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01170	PDGF	HUMAN|HGNC=8800|UniProtKB=P01127	Platelet-derived growth factor subunit B	ISS			PTHR11633:SF2	PLATELET-DERIVED GROWTH FACTOR SUBUNIT B
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00053	T cell activation	P01304	Csk	MONDO|Ensembl=ENSMODG00000009310|UniProtKB=F7GJZ7	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P02752	Mannose metabolism	P03021	GDP Mannose 6-dehydrogenase	PSEAE|EnsemblGenome=PA3540|UniProtKB=P11759	GDP-mannose 6-dehydrogenase	TAS	3108855	PubMed	PTHR43750:SF1	SUBFAMILY NOT NAMED
P05912	Dopamine receptor mediated signaling pathway	P05959	FLNA	MOUSE|MGI=MGI=95556|UniProtKB=Q8BTM8	Filamin-A	ISS	11911837	PubMed	PTHR43998:SF6	FILAMIN-A
P00011	Blood coagulation	P00429	PN2	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00053	T cell activation	P01324	rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00052	TGF-beta signaling pathway	P01275	P38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00023	General transcription regulation	P00668	TFIIB	TAKRU|Ensembl=ENSTRUG00000012520|UniProtKB=H2U442	Uncharacterized protein	ISS			PTHR12458:SF8	CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	CHICK|Ensembl=ENSGALG00000015544|UniProtKB=P07341	Fructose-bisphosphate aldolase B	ISS	85182565	PubMed	PTHR11627:SF2	FRUCTOSE-BISPHOSPHATE ALDOLASE B
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	IDA	10514528	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00057	Wnt signaling pathway	P01457	GBeta	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P06664	Gonadotropin-releasing hormone receptor pathway	P06801	NAB	MOUSE|MGI=MGI=107564|UniProtKB=Q61122	NGFI-A-binding protein 1	RCA			PTHR12623:SF9	NGFI-A-BINDING PROTEIN 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CAEEL|WormBase=WBGene00001745|UniProtKB=Q7KPV0	G protein, Subunit Alpha	IC	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00786	ARF	DROME|FlyBase=FBgn0013750|UniProtKB=P40946	ADP-ribosylation factor 3	IPI	12932731	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P04393	Ras Pathway	P04546	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT1G10210|UniProtKB=Q39021	Mitogen-activated protein kinase 1	ISS	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P02742	Tetrahydrofolate biosynthesis	P02941	Dihydroneopterin aldolase	BACTN|EnsemblGenome=BT_2149|UniProtKB=Q8A5T9	7,8-dihydroneopterin aldolase	ISS			PTHR42844:SF1	DIHYDRONEOPTERIN ALDOLASE
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00030	Hypoxia response via HIF activation	P00819	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00632	Akt	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	IGI	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	XENTR|Xenbase=XB-GENE-480947|UniProtKB=F6ZM17	Uncharacterized protein (Fragment)	ISS	6755374	gi	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000022548|UniProtKB=F6Y9J9	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00053	T cell activation	P01319	PAK	MACMU|Ensembl=ENSMMUG00000012033|UniProtKB=F7GWI2	Serine/threonine-protein kinase PAK 2	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00021	FGF signaling pathway	P00640	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	PANTR|Ensembl=ENSPTRG00000000750|UniProtKB=H2PZ19	Uncharacterized protein	ISS	96032356	PubMed	PTHR11958:SF22	EXCITATORY AMINO ACID TRANSPORTER 5
P00053	T cell activation	P01312	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	CHICK|Ensembl=ENSGALG00000009320|UniProtKB=Q4JIM4	Presenilin-1	IDA	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	MACMU|Ensembl=ENSMMUG00000010031|UniProtKB=F6Q193	TGF-beta receptor type-2	ISS	9759503	PubMed	PTHR23255:SF55	TGF-BETA RECEPTOR TYPE-2
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	BOVIN|Ensembl=ENSBTAG00000009702|UniProtKB=F1N775	Uncharacterized protein	IEP	89264452	PubMed	PTHR13140:SF368	MYOSIN-8
P02750	Lipoate_biosynthesis	P03003	Lipoyl-protein ligase	SCHPO|PomBase=SPAC4F10.05c|UniProtKB=O36017	Probable octanoyltransferase	ISS			PTHR10993:SF7	LIPOYLTRANSFERASE 2, MITOCHONDRIAL-RELATED
P00021	FGF signaling pathway	P00624	14-3-3	CIOIN|Ensembl=ENSCING00000008609|UniProtKB=F6TNW3	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MONDO|Ensembl=ENSMODG00000010315|UniProtKB=F6SRM2	Uncharacterized protein	ISS			PTHR13140:SF255	UNCONVENTIONAL MYOSIN-IC
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	RAT|RGD=621789|UniProtKB=P70539	Activin receptor type-1C	TAS	10683140	PubMed	PTHR23255:SF58	ACTIVIN RECEPTOR TYPE-1C
P00053	T cell activation	P01305	Calmodulin	ANOGA|EnsemblGenome=AGAP010957|UniProtKB=Q7QGY7	AGAP010957-PA (Fragment)	ISS	9753452	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00006	Apoptosis signaling pathway	P00311	GCKR	MOUSE|MGI=MGI=2154405|UniProtKB=Q99JP0	Mitogen-activated protein kinase kinase kinase kinase 3	ISS			PTHR24361:SF205	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT1G10210|UniProtKB=Q39021	Mitogen-activated protein kinase 1	IDA	15218451	gi	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00059	p53 pathway	P04633	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CAEEL|WormBase=WBGene00001187|UniProtKB=Q8MQA1	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00056	VEGF signaling pathway	P01414	PLC-gamma	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	CANLF|Ensembl=ENSCAFG00000011590|UniProtKB=E2R7K9	Ribosomal protein S6 kinase	ISS	15116068	PubMed	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00010	B cell activation	P00402	Jnk	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00006	Apoptosis signaling pathway	P00318	PKCs	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00632	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01123	Bcl-2	BOVIN|Gene=BCL2|UniProtKB=O02718	Apoptosis regulator Bcl-2	ISS	11323415	PubMed	PTHR11256:SF11	APOPTOSIS REGULATOR BCL-2
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	TAKRU|Ensembl=ENSTRUG00000015938|UniProtKB=H2UUX5	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02740	De novo pyrimidine ribonucleotides biosythesis	P02922	Orotate phosphoribosyltransferase	AQUAE|EnsemblGenome=aq_1907|UniProtKB=O67742	Orotate phosphoribosyltransferase	ISS			PTHR19278:SF9	URIDINE 5'-MONOPHOSPHATE SYNTHASE
P00005	Angiogenesis	P00249	PAK	MOUSE|MGI=MGI=1339656|UniProtKB=Q61036	Serine/threonine-protein kinase PAK 3	ISS	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MACMU|Ensembl=ENSMMUG00000009679|UniProtKB=F6YBQ8	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	MOUSE|MGI=MGI=97364|UniProtKB=O35516	Neurogenic locus notch homolog protein 2	IDA	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	IDA	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CHICK|Ensembl=ENSGALG00000001172|UniProtKB=P19439	Probable glutamate receptor	ISS	12778120	PubMed	PTHR18966:SF282	GLUTAMATE RECEPTOR-RELATED
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	IDA	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ORYSJ|EnsemblGenome=OS06G0154500|UniProtKB=Q84UI5	Mitogen-activated protein kinase 1	ISS	20055759	PubMed	PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CAEEL|WormBase=WBGene00000066|UniProtKB=P10986	Actin-4	IC	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00059	p53 pathway	P01480	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IGI	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05923	beta-ARR2	CANLF|Ensembl=ENSCAFG00000015905|UniProtKB=E2QUH6	Uncharacterized protein	ISS	4757780	gi	PTHR11792:SF20	BETA-ARRESTIN-2
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	IPI	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00007	Axon guidance mediated by semaphorins	P00340	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12912997	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00022	General transcription by RNA polymerase I	P00657	TBP	CHICK|Gene=TBP|UniProtKB=O13270	TATA-box-binding protein	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00047	PDGF signaling pathway	P01153	GSK3	MOUSE|MGI=MGI=2152453|UniProtKB=Q2NL51	Glycogen synthase kinase-3 alpha	ISS	183955	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00029	Huntington disease	P00810	GAPDH	CANAL|CGD=CAL0005657|UniProtKB=Q5ADM7	Glyceraldehyde-3-phosphate dehydrogenase	IPI			PTHR10836:SF52	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED
P00057	Wnt signaling pathway	P01471	alpha-catenin	CHICK|Gene=CTNNA2|UniProtKB=P30997	Catenin alpha-2	IDA	9362521	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P00008	Axon guidance mediated by Slit/Robo	P00355	Rho	EMENI|EnsemblGenome=CADANIAG00003322|UniProtKB=Q9C3Y4	GTP-binding protein rhoA	ISS	11973360	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P04393	Ras Pathway	P04558	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	IDA	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	MOUSE|MGI=MGI=1321161|UniProtKB=P62715	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	DROME|FlyBase=FBgn0011286|UniProtKB=Q24498	Ryanodine receptor	ISS	15226293	PubMed	PTHR13715:SF79	RYANODINE RECEPTOR
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00475	Frizzled	BOVIN|Ensembl=ENSBTAG00000020957|UniProtKB=F1MGM1	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF126	FRIZZLED-5
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00892	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8617307	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00025	Hedgehog signaling pathway	P00682	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ORYSJ|EnsemblGenome=OS03G0718100|UniProtKB=Q10DV7	Actin-1	IDA			PTHR11937:SF364	ACTIN-11
P00013	Cell cycle	P00481	APC	ORNAN|Ensembl=ENSOANG00000013919|UniProtKB=F7DUE6	Anaphase-promoting complex subunit 10	ISS	7657035	gi	PTHR12936:SF0	ANAPHASE-PROMOTING COMPLEX SUBUNIT 10
P00013	Cell cycle	P00480	Proteasome	BOVIN|Ensembl=ENSBTAG00000006101|UniProtKB=Q58DA0	26S proteasome non-ATPase regulatory subunit 4	ISS	11827521	PubMed	PTHR10223:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CHICK|Gene=CHRNB3|UniProtKB=P43679	Neuronal acetylcholine receptor subunit beta-3	IC	85270494	PubMed	PTHR18945:SF75	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-3
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00542	EGFR	MOUSE|MGI=MGI=104771|UniProtKB=Q61527	Receptor tyrosine-protein kinase erbB-4	ISS	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00011	Blood coagulation	P00458	GP IIIa	HUMAN|Ensembl=ENSG00000259753|UniProtKB=H3BM21	Integrin beta (Fragment)	ISS	386150	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00005	Angiogenesis	P00231	HSP27	ANOGA|EnsemblGenome=AGAP005547|UniProtKB=Q7Q724	AGAP005547-PA	ISS			PTHR11527:SF252	HEAT SHOCK PROTEIN BETA-11
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00627	ERK1-2	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01142	p90RSK	CHICK|Ensembl=ENSGALG00000016406|UniProtKB=F1NLJ3	Uncharacterized protein	ISS	10480933	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00054	Toll receptor signaling pathway	P01338	IkappaB	MOUSE|MGI=MGI=104741|UniProtKB=Q9Z1E3	NF-kappa-B inhibitor alpha	ISS	99081292	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	MOUSE|MGI=MGI=1339975|UniProtKB=O88643	Serine/threonine-protein kinase PAK 1	ISS	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05731	GABA-B receptor II signaling	P05754	Ggamma	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00036	Interleukin signaling pathway	P00984	MEK	CHICK|Ensembl=ENSGALG00000015596|UniProtKB=E1C063	Uncharacterized protein	ISS			PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P04380	Cortocotropin releasing factor receptor signaling pathway	P04456	ProCRF (Pro Corticotropin-Releasing Factor)	RAT|RGD=620505|UniProtKB=P01143	Corticoliberin	ISS	122560	OMIM	PTHR15035:SF9	CORTICOLIBERIN
P00017	DNA replication	P00527	Histones	CANAL|CGD=CAL0000180612|UniProtKB=Q59VN2	Histone H3.1/H3.2	ISS	20448842	PubMed	PTHR11426:SF169	HISTONE H3
P00029	Huntington disease	P00775	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CANLF|Ensembl=ENSCAFG00000005662|UniProtKB=E2R907	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00029	Huntington disease	P00777	CBP	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00056	VEGF signaling pathway	P01414	PLC-gamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	TAKRU|Ensembl=ENSTRUG00000014690|UniProtKB=H2UKR9	Uncharacterized protein	IDA	11248120	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00036	Interleukin signaling pathway	P00965	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02738	De novo purine biosynthesis	P02899	GMP synthase	MACMU|Ensembl=ENSMMUG00000007324|UniProtKB=F7EE95	Glutamine-hydrolyzing GMP synthase	ISS			PTHR11922:SF2	GMP SYNTHASE  GLUTAMINE-HYDROLYZING
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00010	B cell activation	P00367	NFAT	HUMAN|HGNC=7777|UniProtKB=Q12968	Nuclear factor of activated T-cells, cytoplasmic 3	IDA	12787506	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00053	T cell activation	P01300	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01200	SHIP	BOVIN|Ensembl=ENSBTAG00000019167|UniProtKB=E1BBJ7	Uncharacterized protein	ISS	9824312	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00021	FGF signaling pathway	P00628	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00021	FGF signaling pathway	P00628	JNK1-3	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00012	Cadherin signaling pathway	P00470	F-actin	TAKRU|Ensembl=ENSTRUG00000014318|UniProtKB=H2UI49	Uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00049	Parkinson disease	P01211	ERK	ORYSJ|EnsemblGenome=OS06G0699400|UniProtKB=Q5Z859	Mitogen-activated protein kinase 4	IDA	10851062	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00048	PI3 kinase pathway	P01188	Gbetagamma	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	PANTR|Ensembl=ENSPTRG00000006553|UniProtKB=A5A6H0	C-fos	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00056	VEGF signaling pathway	P01414	PLC-gamma	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	ORNAN|Ensembl=ENSOANG00000000999|UniProtKB=F6WN02	Actin-related protein 2/3 complex subunit 5	ISS	10322212	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	18479080	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00052	TGF-beta signaling pathway	P01288	FKBP12	DANRE|ZFIN=ZDB-GENE-040426-1785|UniProtKB=Q6PBJ1	Peptidyl-prolyl cis-trans isomerase	ISS			PTHR10516:SF341	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01299	TCR Beta	RAT|Ensembl=ENSRNOG00000043164|UniProtKB=D3ZVW0	Protein Trbv19	IDA			PTHR23268:SF28	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00973	PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05734	Synaptic vesicle trafficking	P05778	SNAP-25	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	TAS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MONDO|Ensembl=ENSMODG00000004799|UniProtKB=F6VM87	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00906	Rap1	PANTR|Ensembl=ENSPTRG00000015544|UniProtKB=H2QNL9	RAP2B, member of RAS oncogene family	ISS	8576107	PubMed	PTHR24070:SF194	RAS-RELATED PROTEIN RAP-2B
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00046	Oxidative stress response	P01135	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02742	Tetrahydrofolate biosynthesis	P02951	GTP cyclohydrolase	CAEEL|WormBase=WBGene00000298|UniProtKB=Q19980	GTP cyclohydrolase 1	ISS			PTHR11109:SF0	GTP CYCLOHYDROLASE 1
P00047	PDGF signaling pathway	P01142	p90RSK	HUMAN|HGNC=10436|UniProtKB=P23443	Ribosomal protein S6 kinase beta-1	ISS	15116068	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	ORNAN|Ensembl=ENSOANG00000007724|UniProtKB=F6QTB5	Uncharacterized protein	ISS	12963527	gi	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00049	Parkinson disease	P01236	Casein kinase II	BOVIN|Gene=CSNK2A1|UniProtKB=P68399	Casein kinase II subunit alpha	ISS	10617630	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	IXOSC|EnsemblGenome=ISCW014459|UniProtKB=B7QIS2	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00059	p53 pathway	P04633	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00059	p53 pathway	P01486	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01219	SAPK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00021	FGF signaling pathway	P00648	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04393	Ras Pathway	P04572	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CANLF|Ensembl=ENSCAFG00000018530|UniProtKB=F1PXD3	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00057	Wnt signaling pathway	P01444	Wnt	MACMU|Ensembl=ENSMMUG00000018445|UniProtKB=F7HEW6	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MOUSE|MGI=MGI=97255|UniProtKB=Q02566	Myosin-6	IEP	10938134	PubMed	PTHR13140:SF721	MYOSIN-6
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000008400|UniProtKB=H2QBL4	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF80	CADHERIN-13
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00944	Actin	DANRE|ZFIN=ZDB-GENE-000329-3|UniProtKB=Q7ZVF9	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00508	Cofilin	CHICK|Ensembl=ENSGALG00000010027|UniProtKB=P21566	Cofilin-2	ISS			PTHR11913:SF15	COFILIN-2
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00944	Actin	DANRE|ZFIN=ZDB-GENE-000329-1|UniProtKB=Q7ZVI7	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00049	Parkinson disease	P01219	SAPK	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	NAS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00018	EGF receptor signaling pathway	P00539	14-3-3	MACMU|Ensembl=ENSMMUG00000013855|UniProtKB=F6RM85	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF14	14-3-3 PROTEIN SIGMA
P00006	Apoptosis signaling pathway	P00305	Caspase 3	DANRE|ZFIN=ZDB-GENE-011210-1|UniProtKB=B8JK21	Uncharacterized protein	ISS	9323209	PubMed	PTHR10454:SF198	CASPASE-3
P00018	EGF receptor signaling pathway	P00543	ERK1-2	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	IGI	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00005	Angiogenesis	P00256	PLC-gamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00045	Notch signaling pathway	P01107	Fringe	CANLF|Ensembl=ENSCAFG00000016399|UniProtKB=F1P9A0	Uncharacterized protein	ISS			PTHR10811:SF7	BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE LUNATIC FRINGE
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IGI	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00057	Wnt signaling pathway	P01435	SWI/SNF	MYCTU|EnsemblGenome=LH57_11450|UniProtKB=I6YCF3	Helicase HelZ	ISS	11532957	PubMed	PTHR10799:SF810	SUBFAMILY NOT NAMED
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00012	Cadherin signaling pathway	P00474	Wnt	CHICK|Ensembl=ENSGALG00000011355|UniProtKB=F1P4W5	Protein Wnt	IDA	8717036	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	YEAST|SGD=S000005318|UniProtKB=P53731	Actin-related protein 2/3 complex subunit 2	ISS			PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00059	p53 pathway	G04694	p110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	HUMAN|HGNC=6026|UniProtKB=P25024	C-X-C chemokine receptor type 1	IPI	1840701	PubMed	PTHR10489:SF916	C-X-C CHEMOKINE RECEPTOR TYPE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	DICDI|dictyBase=DDB_G0292804|UniProtKB=O96624	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00006	Apoptosis signaling pathway	P00321	HSP70	TAKRU|Ensembl=ENSTRUG00000002565|UniProtKB=H2S0M6	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF256	HSP70 PROTEIN-RELATED
P02786	Vitamin B6 biosynthesis	P03225	1-Deoxyxylulose-5-phosphate synthase	PLAF7|EnsemblGenome=MAL13P1.186|UniProtKB=Q8IDW0	1-deoxy-D-xylulose 5-phosphate synthase	ISS			PTHR43322:SF5	1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE 1-RELATED
P00029	Huntington disease	P00797	p53	BOVIN|Ensembl=ENSBTAG00000001069|UniProtKB=P67939	Cellular tumor antigen p53	TAS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P04393	Ras Pathway	P04547	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=1306541|UniProtKB=D3ZVF3	Phosphoinositide-3-kinase, class 2, beta polypeptide (Predicted)	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	TAS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000000914|UniProtKB=Q2KIP6	Kappa-type opioid receptor	ISS	11259487	PubMed	PTHR24229:SF1	KAPPA-TYPE OPIOID RECEPTOR
P00036	Interleukin signaling pathway	P00983	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01414	PLC-gamma	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	BOVIN|Ensembl=ENSBTAG00000011390|UniProtKB=P04759	Acetylcholine receptor subunit delta	IC	85203892	PubMed	PTHR18945:SF61	ACETYLCHOLINE RECEPTOR SUBUNIT DELTA
P00046	Oxidative stress response	P01138	MKK4	BOVIN|Ensembl=ENSBTAG00000012103|UniProtKB=A5PJP8	MAP2K4 protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CHICK|Ensembl=ENSGALG00000027629|UniProtKB=Q5ZJ03	Guanine nucleotide-binding protein subunit gamma	IDA	11313908	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MOUSE|MGI=MGI=1919210|UniProtKB=Q6URW6	Myosin-14	ISS	89264452	PubMed	PTHR13140:SF462	MYOSIN-14
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	TAKRU|Ensembl=ENSTRUG00000007253|UniProtKB=H2SZQ1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00036	Interleukin signaling pathway	P00981	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	TAS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00005	Angiogenesis	P00223	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	ISS	10704417	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	DANRE|ZFIN=ZDB-GENE-020604-1|UniProtKB=Q6IQX1	Myosin, heavy polypeptide 2, fast muscle specific	ISS	89264452	PubMed	PTHR13140:SF676	MYOSIN, HEAVY POLYPEPTIDE 2, FAST MUSCLE SPECIFIC
P00034	Integrin signalling pathway	P00951	Jnk	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000008751|UniProtKB=H2QC89	Uncharacterized protein	ISS	12507995	PubMed	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00036	Interleukin signaling pathway	P00978	Jak	MOUSE|MGI=MGI=99928|UniProtKB=Q62137	Tyrosine-protein kinase JAK3	ISS	15179321	PubMed	PTHR24418:SF233	TYROSINE-PROTEIN KINASE JAK3
P00012	Cadherin signaling pathway	P00470	F-actin	HUMAN|HGNC=17780|UniProtKB=Q562R1	Beta-actin-like protein 2	IC	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	BOVIN|Ensembl=ENSBTAG00000002295|UniProtKB=F1N177	Uncharacterized protein	ISS	7875593	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00021	FGF signaling pathway	P00646	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	8270251	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00049	Parkinson disease	P01242	Casein kinase I	CHICK|Gene=CSNK1A1|UniProtKB=P67962	Casein kinase I isoform alpha	IDA	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00021	FGF signaling pathway	P00648	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IGI	10644715	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00021	FGF signaling pathway	P00628	JNK1-3	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IGI	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6880|UniProtKB=Q13164	Mitogen-activated protein kinase 7	ISS	15085193	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00036	Interleukin signaling pathway	P00965	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00005	Angiogenesis	P00251	cPLA2	DANRE|ZFIN=ZDB-GENE-041114-140|UniProtKB=F1QD56	Uncharacterized protein	ISS			PTHR10728:SF39	CYTOSOLIC PHOSPHOLIPASE A2 GAMMA
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	RAT|RGD=1306040|UniProtKB=Q6QDP7	Cyclic AMP-responsive element-binding protein 3-like protein 2	ISS	123810	OMIM	PTHR22952:SF96	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 2
P00029	Huntington disease	P00790	beta-Tubulin	ASHGO|EnsemblGenome=AGOS_ACR225C|UniProtKB=Q75BP6	ACR225Cp	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00011	Blood coagulation	P00414	Thrombin	PANTR|Ensembl=ENSPTRG00000003552|UniProtKB=H2Q3I2	Prothrombin	ISS	176930	OMIM	PTHR24254:SF10	PROTHROMBIN
P00046	Oxidative stress response	P01134	cPLA2	MACMU|Ensembl=ENSMMUG00000021423|UniProtKB=F7EEZ1	Phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00005	Angiogenesis	P00206	Wnt	HUMAN|HGNC=12781|UniProtKB=Q93097	Protein Wnt-2b	IEA	8717036	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	RAT|RGD=3571|UniProtKB=P49804	Regulator of G-protein signaling 8	IDA	8756726	PubMed	PTHR10845:SF147	REGULATOR OF G-PROTEIN SIGNALING 8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	SYNY3|EnsemblGenome=BAA17318|UniProtKB=P73290	Adenylosuccinate synthetase	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	RCA	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01151	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	RAT|RGD=2732|UniProtKB=P22756	Glutamate receptor ionotropic, kainate 1	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DICPU|Gene=DICPUDRAFT_90232|UniProtKB=F1A175	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00048	PI3 kinase pathway	P01177	P110ACT	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00187	beta catenin	BOVIN|Ensembl=ENSBTAG00000016420|UniProtKB=Q0VCX4	Catenin beta-1	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00021	FGF signaling pathway	P00634	MEKK1-5	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	ISS	8940199	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P05917	Opioid proopiomelanocortin pathway	P06011	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00021	FGF signaling pathway	P00627	ERK1-2	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00060	Ubiquitin proteasome pathway	P01490	E3	PANTR|Ensembl=ENSPTRG00000014936|UniProtKB=H2QMM5	Uncharacterized protein	ISS			PTHR10953:SF143	UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 7
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	IDA	12001934	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00029	Huntington disease	P00780	Microtubule	PHYPA|Gene=PHYPADRAFT_117822|UniProtKB=A9RQS1	Predicted protein	ISS	9454836	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00812	Caspase 3	MACMU|Ensembl=ENSMMUG00000012053|UniProtKB=F7HFY2	Uncharacterized protein	ISS	9323209	PubMed	PTHR10454:SF198	CASPASE-3
P04393	Ras Pathway	P04570	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01087	CAT	CHICK|Gene=CHAT|UniProtKB=Q90YJ9	Choline O-acetyltransferase	IC	92155737	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	RAT|RGD=62030|UniProtKB=P02564	Myosin-7	IC	89264452	PubMed	PTHR13140:SF344	MYOSIN-7
P02748	Isoleucine biosynthesis	P02996	Ketol-acid reductoisomerase	YEAST|SGD=S000004347|UniProtKB=P06168	Ketol-acid reductoisomerase, mitochondrial	ISS			PTHR21371:SF13	KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL
P00049	Parkinson disease	P01211	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	176948	OMIM	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	DROME|FlyBase=FBgn0027090|UniProtKB=Q9Y105	Probable glutamine--tRNA ligase	ISS			PTHR43097:SF4	GLUTAMINE--TRNA LIGASE-RELATED
P00005	Angiogenesis	P00187	beta catenin	RAT|RGD=70487|UniProtKB=Q9WU82	Catenin beta-1	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00036	Interleukin signaling pathway	P00976	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04393	Ras Pathway	P04550	Ral	RAT|RGD=619851|UniProtKB=P63322	Ras-related protein Ral-A	ISS	11025226	PubMed	PTHR24070:SF174	RAS-RELATED PROTEIN RAL-A
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	IC	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	ORNAN|Ensembl=ENSOANG00000000818|UniProtKB=F6PLI7	Uncharacterized protein	ISS	11431030	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00056	VEGF signaling pathway	P01414	PLC-gamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	CANLF|Ensembl=ENSCAFG00000015004|UniProtKB=E2RGD0	Uncharacterized protein	ISS	15032587	PubMed	PTHR44282:SF2	SUPPRESSOR OF CYTOKINE SIGNALING 4
P00010	B cell activation	P00398	IP3R	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	IGI	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CANLF|Ensembl=ENSCAFG00000010764|UniProtKB=Q28300	Guanine nucleotide-binding protein G(t) subunit alpha-1	ISS	10188796	PubMed	PTHR10218:SF67	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-1
P00047	PDGF signaling pathway	P01162	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	PANTR|Gene=CHRM5|UniProtKB=Q5IS53	Muscarinic acetylcholine receptor M5	ISS	11166329	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00054	Toll receptor signaling pathway	P01354	NFkappaB	PANTR|Ensembl=ENSPTRG00000002888|UniProtKB=H2Q2H2	Uncharacterized protein	ISS	12574369	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00050	Plasminogen activating cascade	P01254	pro-MMP-13	XENTR|Xenbase=XB-GENE-481559|UniProtKB=F6SRT1	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF165	COLLAGENASE 3
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00203	Erk	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	HUMAN|HGNC=11892|UniProtKB=P01375	Tumor necrosis factor	ISS	11911478	PubMed	PTHR11471:SF23	TUMOR NECROSIS FACTOR
P00003	Alzheimer disease-amyloid secretase pathway	P00084	X11alpha	MOUSE|MGI=MGI=1888527|UniProtKB=O88888	Amyloid beta A4 precursor protein-binding family A member 3	IDA	9614075	PubMed	PTHR12345:SF9	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Gene=PKN1|UniProtKB=A1A4I4	Serine/threonine-protein kinase N1	ISS	11554554	PubMed	PTHR24356:SF246	SERINE/THREONINE-PROTEIN KINASE N1
P00020	FAS signaling pathway	P00615	JNK	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00018	EGF receptor signaling pathway	P00551	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IGI	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	MOUSE|MGI=MGI=98262|UniProtKB=P30882	C-C motif chemokine 5	ISS	250208	gi	PTHR12015:SF82	C-C MOTIF CHEMOKINE 5
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	MOUSE|MGI=MGI=94890|UniProtKB=P00375	Dihydrofolate reductase	ISS			PTHR22778:SF16	DIHYDROFOLATE REDUCTASE
P00047	PDGF signaling pathway	P01151	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00036	Interleukin signaling pathway	P00978	Jak	PANTR|Ensembl=ENSPTRG00000010685|UniProtKB=H2R074	Tyrosine-protein kinase	ISS	15179321	PubMed	PTHR24418:SF233	TYROSINE-PROTEIN KINASE JAK3
P00019	Endothelin signaling pathway	P00577	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00012	Cadherin signaling pathway	P00467	alpha-catenin	BOVIN|Gene=CTNNA1|UniProtKB=Q3MHM6	Catenin alpha-1	ISS	9362521	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00018	EGF receptor signaling pathway	P00564	Rac	CANLF|Ensembl=ENSCAFG00000017087|UniProtKB=E2QU83	Uncharacterized protein	ISS			PTHR24072:SF150	RAS HOMOLOG GENE FAMILY, MEMBER GA-RELATED
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	RAT|RGD=620967|UniProtKB=F1M9D0	Protein Map3k2	ISS	11730323	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	DROME|FlyBase=FBgn0025595|UniProtKB=Q7KTL9	Adipokinetic hormone receptor, isoform C	IDA	1333052	PubMed	PTHR24241:SF59	ADIPOKINETIC HORMONE RECEPTOR, ISOFORM C
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05912	Dopamine receptor mediated signaling pathway	P05955	DBH	RAT|RGD=2489|UniProtKB=Q05754	Dopamine beta-hydroxylase	ISS	90219125	PubMed	PTHR10157:SF29	DOPAMINE BETA-HYDROXYLASE
P00010	B cell activation	P00402	Jnk	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04398	p53 pathway feedback loops 2	P04668	p53	PANTR|Ensembl=ENSPTRG00000008703|UniProtKB=H2QC53	Cellular tumor antigen p53	ISS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	MACMU|Ensembl=ENSMMUG00000021075|UniProtKB=F7GY91	Uncharacterized protein	ISS	11756405	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00057	Wnt signaling pathway	P01440	Cadherin	CANLF|Ensembl=ENSCAFG00000019049|UniProtKB=F6Y5X3	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF106	CADHERIN-18
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	MOUSE|MGI=MGI=109284|UniProtKB=Q61144	Presenilin-2	IDA	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02779	Thiamin biosynthesis	P03175	1-Deoxyxylulose-5-phosphate synthase	ARATH|TAIR=AT4G15560|UniProtKB=Q38854	1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic	ISS			PTHR43322:SF5	1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE 1-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04393	Ras Pathway	P04563	Ets	RAT|RGD=2583|UniProtKB=P41156	Protein C-ets-1	IDA	15579511	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IDA	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P02723	Adenine and hypoxanthine salvage pathway	P02808	Deoxyadenosine phosphorylase	MOUSE|MGI=MGI=97365|UniProtKB=P23492	Purine nucleoside phosphorylase	ISS	7903568	PubMed	PTHR11904:SF12	PURINE NUCLEOSIDE PHOSPHORYLASE
P00036	Interleukin signaling pathway	P00973	PKB	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00059	p53 pathway	P04623	CBP	CAEEL|WormBase=WBGene00010545|UniProtKB=G5EBG3	CBP/p300 homolog	ISS	10769018	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00036	Interleukin signaling pathway	P00964	p90RSK	PANTR|Ensembl=ENSPTRG00000022064|UniProtKB=H2QYE0	Uncharacterized protein	ISS	6755374	gi	PTHR24351:SF98	RIBOSOMAL PROTEIN S6 KINASE ALPHA-6
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00006	Apoptosis signaling pathway	P00269	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	97449291	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00018	EGF receptor signaling pathway	P00559	MEK1-2	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ORYSJ|EnsemblGenome=OS05G0106600|UniProtKB=Q65XH8	Os05g0106600 protein	ISS	10974003	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	RAT|RGD=2035|UniProtKB=Q03343	Adenylate cyclase type 6	IDA	93028552	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01188	Gbetagamma	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00057	Wnt signaling pathway	P01431	LRP5/6	MOUSE|MGI=MGI=1278315|UniProtKB=Q91VN0	Low-density lipoprotein receptor-related protein 5	ISS	11029006	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00048	PI3 kinase pathway	P01199	Galpha	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	IC	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	IC	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00053	T cell activation	P01300	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=1953|UniProtKB=P08173	Muscarinic acetylcholine receptor M4	IDA	11166329	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P02771	Pyrimidine Metabolism	P03129	Aminotransferase	EMENI|EnsemblGenome=CADANIAG00008938|UniProtKB=P14010	4-aminobutyrate aminotransferase	IEP	8133261	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P04392	P53 pathway feedback loops 1	P04539	p53	MOUSE|MGI=MGI=1336991|UniProtKB=Q9JJP2	Tumor protein p73	TAS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1346873|UniProtKB=Q61083	Mitogen-activated protein kinase kinase kinase 2	IC			PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00019	Endothelin signaling pathway	P00572	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	89186920	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04393	Ras Pathway	P04547	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	IC	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	TAS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000007445|UniProtKB=F6SWI4	Uncharacterized protein	ISS	20088160	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=109356|UniProtKB=O09044	Synaptosomal-associated protein 23	IC	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P02738	De novo purine biosynthesis	P02889	dGDP kinase	MYCTU|EnsemblGenome=Rv2445c|UniProtKB=P9WJH7	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	DANRE|ZFIN=ZDB-GENE-980526-416|UniProtKB=Q92048	Protein Wnt-2	TAS	11266476	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00029	Huntington disease	P00761	Truncated Htt	HUMAN|HGNC=4851|UniProtKB=P42858	Huntingtin	TAS	8268927	PubMed	PTHR10170:SF10	HUNTINGTIN
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	15572354	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00310	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00973	PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01444	Wnt	DANRE|ZFIN=ZDB-GENE-990415-279|UniProtKB=P51029	Protein Wnt-8b	IDA	8717036	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05731	GABA-B receptor II signaling	P05754	Ggamma	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00036	Interleukin signaling pathway	P00968	Ikk	MACMU|Ensembl=ENSMMUG00000018476|UniProtKB=F6X938	Uncharacterized protein	ISS	9346484	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00050	Plasminogen activating cascade	P01253	Fibrin	XENTR|Xenbase=XB-GENE-483216|UniProtKB=B0JZ09	Fgb protein	ISS	95369693	PubMed	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00059	p53 pathway	P01486	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	DROME|FlyBase=FBgn0001123|UniProtKB=P20354	G protein alpha s subunit	IC	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00048	PI3 kinase pathway	P01185	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00053	T cell activation	P01298	NFkappaB	PANTR|Ensembl=ENSPTRG00000002888|UniProtKB=H2Q2H2	Uncharacterized protein	ISS	9133421	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00018	EGF receptor signaling pathway	P00552	Ras	CHICK|Ensembl=ENSGALG00000006885|UniProtKB=P08642	GTPase HRas	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00007	Axon guidance mediated by semaphorins	P00340	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06744	PPARalpha/gamma	MOUSE|MGI=MGI=97747|UniProtKB=P37238	Peroxisome proliferator-activated receptor gamma	RCA			PTHR24082:SF14	PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	RAT|RGD=1304749|UniProtKB=A0A0G2K0H3	Protein Lrp6	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00036	Interleukin signaling pathway	P00990	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01177	P110ACT	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CHICK|Ensembl=ENSGALG00000013785|UniProtKB=E1BS74	Uncharacterized protein	ISS	6309844	PubMed	PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	ARATH|TAIR=AT1G06390|UniProtKB=Q39012	Shaggy-related protein kinase iota	TAS			PTHR24057:SF12	SHAGGY-RELATED PROTEIN KINASE IOTA-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00508	Cofilin	XENTR|Xenbase=XB-GENE-1016481|UniProtKB=Q6NX11	Cofilin-1	ISS			PTHR11913:SF17	COFILIN-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06848	SF1	MOUSE|MGI=MGI=1346833|UniProtKB=P33242	Steroidogenic factor 1	RCA			PTHR24086:SF24	STEROIDOGENIC FACTOR 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04393	Ras Pathway	P04557	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00056	VEGF signaling pathway	P01401	HIF-1	MACMU|Ensembl=ENSMMUG00000021002|UniProtKB=F7HKJ2	Uncharacterized protein	ISS	9606183	PubMed	PTHR23043:SF7	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DAPPU|EnsemblGenome=DAPPUDRAFT_188187|UniProtKB=E9GJ31	Guanine nucleotide binding protein, q polypeptide	ISS	14765990	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00021	FGF signaling pathway	P00633	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	3035212	PubMed	PTHR24070:SF385	GTPASE HRAS
P04397	p53 pathway by glucose deprivation	P04641	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00057	Wnt signaling pathway	P01443	Phospholipase C	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	RAT|RGD=2026|UniProtKB=P68035	Actin, alpha cardiac muscle 1	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P06587	Nicotine pharmacodynamics pathway	P06595	CHRNA3	MACMU|Ensembl=ENSMMUG00000023736|UniProtKB=F7G778	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P00053	T cell activation	P01330	IKK	MACMU|Ensembl=ENSMMUG00000018476|UniProtKB=F6X938	Uncharacterized protein	ISS	12235208	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	TAS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06959	CCKR signaling map	P07090	MAPK8-10	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	RCA	8621433	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	BOVIN|Gene=FURIN|UniProtKB=Q28193	Furin	IDA	95328031	PubMed	PTHR42884:SF1	FURIN
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00047	PDGF signaling pathway	P01153	GSK3	SCHPO|PomBase=SPAC1687.15|UniProtKB=Q10452	Protein kinase gsk3	ISS	7529201	PubMed	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00828	Galphai	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	RCA			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00046	Oxidative stress response	P01129	JNK1/2	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00049	Parkinson disease	P01238	14-3-3	DANRE|ZFIN=ZDB-GENE-030131-6583|UniProtKB=Q5PRD0	14-3-3 protein beta/alpha-A	ISS	10407019	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00117	E-cadherin C-terminal fragment	PANTR|Ensembl=ENSPTRG00000008269|UniProtKB=H2QBE4	Cadherin 3, type 1, P-cadherin (Placental)	ISS	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P00006	Apoptosis signaling pathway	P00321	HSP70	CANLF|Ensembl=ENSCAFG00000001886|UniProtKB=H9GW49	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF239	HEAT SHOCK COGNATE 71 KDA PROTEIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	G04709	MDM-2	MACMU|Ensembl=ENSMMUG00000014193|UniProtKB=F7AKR9	Uncharacterized protein	ISS	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=87936|UniProtKB=Q01337	Alpha-2C adrenergic receptor	IDA	11781138	PubMed	PTHR24248:SF25	ALPHA-2C ADRENERGIC RECEPTOR
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00049	Parkinson disease	P01240	hSel10	MOUSE|MGI=MGI=2144023|UniProtKB=Q5SRY7	F-box/WD repeat-containing protein 11	IDA			PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00010	B cell activation	P00388	PLC gamma2	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00034	Integrin signalling pathway	P00941	Integrin alpha	BOVIN|Ensembl=ENSBTAG00000008373|UniProtKB=E1BDD5	Uncharacterized protein	ISS	3487386	PubMed	PTHR23220:SF26	INTEGRIN ALPHA-10
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	ISS	1319556	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00059	p53 pathway	G04694	p110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PANTR|Ensembl=ENSPTRG00000008771|UniProtKB=H2QCA0	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF484	MYOSIN-1
P00047	PDGF signaling pathway	P01168	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	11251832	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00010	B cell activation	P00384	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04395	Vasopressin synthesis	P04589	Signal Peptidase	HUMAN|HGNC=17718|UniProtKB=P67812	Signal peptidase complex catalytic subunit SEC11A	IC	2674115	PubMed	PTHR10806:SF8	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11A-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_79607|UniProtKB=C3ZHN4	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00010	B cell activation	P00379	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IPI	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	CANLF|Ensembl=ENSCAFG00000013159|UniProtKB=E2RAF3	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF79	FRIZZLED-9
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	EMENI|EnsemblGenome=CADANIAG00002670|UniProtKB=Q5BH99	G-protein beta subunit [Source:UniProtKB/TrEMBLAcc:O74214]	IC	10523303	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	YEAST|SGD=S000004747|UniProtKB=P38615	Serine/threonine-protein kinase RIM11/MSD1	IDA	7529201	PubMed	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00034	Integrin signalling pathway	P00924	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IPI	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MOUSE|MGI=MGI=88397|UniProtKB=Q9ERZ4	Muscarinic acetylcholine receptor M2	TAS	11166329	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00833	RGS	MOUSE|MGI=MGI=1859709|UniProtKB=P97492	Regulator of G-protein signaling 14	IDA	8756726	PubMed	PTHR10845:SF179	REGULATOR OF G-PROTEIN SIGNALING 14
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	MACMU|Ensembl=ENSMMUG00000010173|UniProtKB=F7AGU8	Presenilin	ISS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06812	L-type Ca2+	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	RCA	11956331	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00019	Endothelin signaling pathway	P00591	PLCbeta	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	RCA	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05916	Opioid prodynorphin pathway	P05999	provasopressin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	IDA	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	IC	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00060	Ubiquitin proteasome pathway	P01492	E1	DROME|FlyBase=FBgn0029512|UniProtKB=Q7KSM5	Activator of SUMO 1	ISS			PTHR10953:SF162	SUMO-ACTIVATING ENZYME SUBUNIT 1
P00034	Integrin signalling pathway	P00907	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02723	Adenine and hypoxanthine salvage pathway	P02808	Deoxyadenosine phosphorylase	MYCTU|EnsemblGenome=Rv3307|UniProtKB=P9WP01	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00034	Integrin signalling pathway	P00920	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00034	Integrin signalling pathway	P00917	ELMO	PANTR|Ensembl=ENSPTRG00000019087|UniProtKB=H2QUF7	Engulfment and cell motility 1	ISS	12879077	PubMed	PTHR12771:SF23	ENGULFMENT AND CELL MOTILITY PROTEIN 1
P00034	Integrin signalling pathway	P00948	Rho	MOUSE|MGI=MGI=106028|UniProtKB=Q62159	Rho-related GTP-binding protein RhoC	IGI	12090470	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00029	Huntington disease	P00807	Actin	ORYSJ|EnsemblGenome=OS12G0163700|UniProtKB=Q0IPW3	Os12g0163700 protein	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02918	dUTP pyrophosphatase	FUSNN|EnsemblGenome=FN1028|UniProtKB=Q8RER7	Deoxyuridine 5'-triphosphate nucleotidohydrolase	ISS			PTHR11241:SF0	BCDNA.LD08534
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CANAL|CGD=CAL0064759|UniProtKB=Q5AKX0	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00037	Ionotropic glutamate receptor pathway	P01026	KA	RAT|RGD=71027|UniProtKB=P42264	Glutamate receptor ionotropic, kainate 3	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	BOVIN|Ensembl=ENSBTAG00000009065|UniProtKB=F1MXH6	Uncharacterized protein	ISS	12697749	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00113	Erb-B4 transmembrane fragment	PANTR|Ensembl=ENSPTRG00000012883|UniProtKB=H2QJC5	Receptor protein-tyrosine kinase	ISS	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00048	PI3 kinase pathway	P01200	SHIP	CANLF|Ensembl=ENSCAFG00000005743|UniProtKB=F1PNY0	Uncharacterized protein	ISS	10381377	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00053	T cell activation	P01300	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00049	Parkinson disease	P01211	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	PANTR|Ensembl=ENSPTRG00000017236|UniProtKB=H2QRH6	Uncharacterized protein	ISS	12356903	PubMed	PTHR10373:SF33	TRANSCRIPTION FACTOR 7
P00046	Oxidative stress response	P01129	JNK1/2	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	TAS	97102676	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00001	Adrenaline and noradrenaline biosynthesis	P00068	amine translocator	HUMAN|HGNC=30927|UniProtKB=Q9NP91	Sodium- and chloride-dependent transporter XTRP3	IC	12719981	PubMed	PTHR11616:SF44	SODIUM- AND CHLORIDE-DEPENDENT TRANSPORTER XTRP3
P02738	De novo purine biosynthesis	P02902	ADP reductase	SULSO|EnsemblGenome=SSO0929|UniProtKB=Q97ZH9	Ribonucleotide reductase (Nrd)	ISS			PTHR43371:SF1	SUBFAMILY NOT NAMED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MACMU|Ensembl=ENSMMUG00000005032|UniProtKB=F7ARY1	Uncharacterized protein	ISS			PTHR13140:SF706	UNCONVENTIONAL MYOSIN-VI
P00006	Apoptosis signaling pathway	P00303	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00034	Integrin signalling pathway	P00947	Laminin	HUMAN|HGNC=6491|UniProtKB=A4D0S4	Laminin subunit beta-4	IPI	2538453	PubMed	PTHR10574:SF279	LAMININ SUBUNIT BETA-4
P00059	p53 pathway	P01485	p53	CANLF|Gene=TP53|UniProtKB=Q29537	Cellular tumor antigen p53	TAS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00021	FGF signaling pathway	P00645	Rac	DROME|FlyBase=FBgn0014011|UniProtKB=P48554	Ras-related protein Rac2	ISS	12932731	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00059	p53 pathway	P04609	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04397	p53 pathway by glucose deprivation	P04641	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00029	Huntington disease	G01535	PIG3	PANTR|Ensembl=ENSPTRG00000011710|UniProtKB=H2QHI8	Tumor protein p53 inducible protein 3	ISS	12932731	PubMed	PTHR43006:SF2	QUINONE OXIDOREDUCTASE PIG3
P02750	Lipoate_biosynthesis	P03004	Lipoate synthase	CHICK|Ensembl=ENSGALG00000014312|UniProtKB=F1NEN8	Lipoyl synthase, mitochondrial	ISS			PTHR10949:SF0	LIPOYL SYNTHASE, MITOCHONDRIAL
P00038	JAK/STAT signaling pathway	P01027	STAT	CANLF|Ensembl=ENSCAFG00000015213|UniProtKB=E2RB82	Signal transducer and activator of transcription	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	RAT|RGD=3187|UniProtKB=Q07008	Neurogenic locus notch homolog protein 1	IDA	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00005	Angiogenesis	P00237	FRP	MONDO|Ensembl=ENSMODG00000008701|UniProtKB=F6PWM3	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF22	FRIZZLED-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00048	PI3 kinase pathway	P01199	Galpha	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05731	GABA-B receptor II signaling	P05755	Gbeta	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	BOVIN|Ensembl=ENSBTAG00000034854|UniProtKB=F1N246	Uncharacterized protein	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BRAFL|Gene=BRAFLDRAFT_220697|UniProtKB=C3ZSF0	Putative uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00019	Endothelin signaling pathway	P00589	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IGI	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=1755|UniProtKB=O75309	Cadherin-16	IDA	8120095	PubMed	PTHR24028:SF1	CADHERIN-16
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CANLF|Ensembl=ENSCAFG00000004930|UniProtKB=E2RFB5	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00030	Hypoxia response via HIF activation	P00819	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IDA	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DROME|FlyBase=FBgn0000045|UniProtKB=P02574	Actin, larval muscle	IC	10974003	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00034	Integrin signalling pathway	P00919	Arf6	MONDO|Ensembl=ENSMODG00000023914|UniProtKB=F7FYA6	Uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1712|UniProtKB=Q6PBY0	Guanine nucleotide binding protein (G protein), beta 5	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00036	Interleukin signaling pathway	P00967	c-fos	BOVIN|Ensembl=ENSBTAG00000004322|UniProtKB=O77628	Proto-oncogene c-Fos	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	TAS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	TAS	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	YEAST|SGD=S000001295|UniProtKB=P07278	cAMP-dependent protein kinase regulatory subunit	IC	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	SCHPO|PomBase=SPBC1709.17|UniProtKB=O74742	Probable folylpolyglutamate synthase	ISS			PTHR11136:SF5	FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	RAT|RGD=2344|UniProtKB=P08485	Muscarinic acetylcholine receptor M4	TAS	12181435	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00049	Parkinson disease	P01211	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	13430383	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	IC	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P06664	Gonadotropin-releasing hormone receptor pathway	P06793	Insulin	MOUSE|MGI=MGI=96573|UniProtKB=P01326	Insulin-2	RCA			PTHR11454:SF29	INSULIN-2
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00045	Notch signaling pathway	P01109	Aph-1	PANTR|Ensembl=ENSPTRG00000001250|UniProtKB=H2R2D2	Anterior pharynx defective 1 homolog A	ISS			PTHR12889:SF3	GAMMA-SECRETASE SUBUNIT APH-1A
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=106621|UniProtKB=E9Q634	Unconventional myosin-Ie	ISS			PTHR13140:SF341	UNCONVENTIONAL MYOSIN-IE
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	89186920	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	TAKRU|Ensembl=ENSTRUG00000006464|UniProtKB=H2STT5	Uncharacterized protein	ISS	10476970	PubMed	PTHR24070:SF382	RAS-RELATED PROTEIN RAP-1B
P00005	Angiogenesis	P00221	JNK1	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	LEIMA|EnsemblGenome=LmjF.14.1320|UniProtKB=Q4QFK2	Serine hydroxymethyltransferase	ISS			PTHR11680:SF28	SERINE HYDROXYMETHYLTRANSFERASE 1
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DICDI|dictyBase=DDB_G0289811|UniProtKB=Q54GX7	Actin-10	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF31	SUBFAMILY NOT NAMED
P06211	BMP/activin signaling pathway-drosophila	P06255	TGFbetaR II	DROME|Gene=Dmel_CG7904|UniProtKB=A0A0B4KG59	Serine/threonine-protein kinase receptor	RCA	9395284	PubMed	PTHR23255:SF70	SERINE/THREONINE-PROTEIN KINASE RECEPTOR
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00896	Insulin IGF	MOUSE|MGI=MGI=96573|UniProtKB=P01326	Insulin-2	ISS			PTHR11454:SF29	INSULIN-2
P04398	p53 pathway feedback loops 2	P04658	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	ANOGA|EnsemblGenome=AGAP001478|UniProtKB=Q7PXM3	AGAP001478-PA	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00036	Interleukin signaling pathway	P00990	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	PANTR|Ensembl=ENSPTRG00000013695|UniProtKB=H2REF4	Uncharacterized protein	ISS	10973244	PubMed	PTHR15138:SF18	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4
P00029	Huntington disease	P00807	Actin	MACMU|Ensembl=ENSMMUG00000009341|UniProtKB=F6UA54	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MOUSE|MGI=MGI=88144|UniProtKB=Q61125	B1 bradykinin receptor	IDA	12130679	PubMed	PTHR24228:SF28	B1 BRADYKININ RECEPTOR
P02761	Pantothenate biosynthesis	P03068	Pantoate-beta-alanine ligase	LEPIN|EnsemblGenome=LA_2514|UniProtKB=Q8F394	Pantothenate synthetase	ISS			PTHR21299:SF1	PANTOATE--BETA-ALANINE LIGASE
P00010	B cell activation	P00384	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IDA	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	8787761	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	TAKRU|Ensembl=ENSTRUG00000008289|UniProtKB=H2T7U8	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF129	CDC42L PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	CHICK|Ensembl=ENSGALG00000002719|UniProtKB=E1BVW0	Uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MONDO|Ensembl=ENSMODG00000004799|UniProtKB=F6VM87	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00049	Parkinson disease	P01226	CDCrel-1	CHICK|Ensembl=ENSGALG00000001688|UniProtKB=F1NVL5	Uncharacterized protein	ISS	11078524	PubMed	PTHR18884:SF68	SEPTIN-5
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ENTHI|EnsemblGenome=EHI_107290|UniProtKB=B1N2P0	Actin	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00030	Hypoxia response via HIF activation	P00817	TOR	BOVIN|Ensembl=ENSBTAG00000015325|UniProtKB=E1BFB4	Uncharacterized protein	ISS	8662507	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DANRE|ZFIN=ZDB-GENE-030131-1229|UniProtKB=Q6DHS1	Actin, alpha 2, smooth muscle, aorta	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00059	p53 pathway	P01486	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01332	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04547	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00019	Endothelin signaling pathway	P00587	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IDA	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	HUMAN|HGNC=4573|UniProtKB=P42263	Glutamate receptor 3	ISS	10331083	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MOUSE|MGI=MGI=1339711|UniProtKB=Q5SX40	Myosin-1	ISS	10938134	PubMed	PTHR13140:SF484	MYOSIN-1
P00006	Apoptosis signaling pathway	P00322	Cytochrome C	MACMU|Ensembl=ENSMMUG00000031718|UniProtKB=F7BMG9	Uncharacterized protein	ISS			PTHR11961:SF15	CYTOCHROME C
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DANRE|ZFIN=ZDB-GENE-040426-1354|UniProtKB=Q7T2C5	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	MACMU|Ensembl=ENSMMUG00000009885|UniProtKB=F6YL51	Uncharacterized protein	ISS	11907044	PubMed	PTHR44025:SF7	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B
P00010	B cell activation	P00402	Jnk	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DAPPU|EnsemblGenome=DAPPUDRAFT_59367|UniProtKB=E9H7Z0	Guanine nucleotide-binding protein G(O) subunit alpha 1	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MACMU|Ensembl=ENSMMUG00000007027|UniProtKB=F7F210	Alpha-cardiac actin	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CANLF|Ensembl=ENSCAFG00000008756|UniProtKB=F2Z4N8	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00004	Alzheimer disease-presenilin pathway	P00148	Erb-B4 N-terminal fragment	MACMU|Ensembl=ENSMMUG00000001674|UniProtKB=F7G3H1	Receptor protein-tyrosine kinase	ISS	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00048	PI3 kinase pathway	P01199	Galpha	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CAEEL|WormBase=WBGene00000366|UniProtKB=P34545	Protein cbp-1	TAS	8413673	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IC	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	ORNAN|Ensembl=ENSOANG00000005134|UniProtKB=F6WFN3	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF335	MYOSIN-11
P00024	Glycolysis	P00679	Aldolase	PANTR|Gene=ALDOA|UniProtKB=A5A6I5	Fructose-bisphosphate aldolase A	ISS	4812352	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P04393	Ras Pathway	P04551	RalGDS	RAT|RGD=1308947|UniProtKB=A0A0G2JV91	Lethal(2) giant larvae protein homolog 1	ISS			PTHR23113:SF199	RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 1
P00053	T cell activation	P01312	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IDA	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	188830	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00015	Circadian clock system	G01501	cry	CANLF|Ensembl=ENSCAFG00000009379|UniProtKB=F1PNC9	Uncharacterized protein	ISS	14507900	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00005	Angiogenesis	P00203	Erk	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	DANRE|ZFIN=ZDB-GENE-020125-3|UniProtKB=E7F1V8	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00036	Interleukin signaling pathway	P00983	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00007	Axon guidance mediated by semaphorins	P00340	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	3045562	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00203	Erk	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00058	mRNA splicing	P01478	U2	HUMAN|HGNC=11155|UniProtKB=P08579	U2 small nuclear ribonucleoprotein B''	ISS			PTHR10501:SF21	U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B''
P00018	EGF receptor signaling pathway	P00551	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IGI	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P02751	Lysine biosynthesis	P03011	N-succinyldiaminopimelate  aminotransferase	METAC|EnsemblGenome=MA_0119|UniProtKB=Q8TUE8	Acetylornithine aminotransferase	IDA			PTHR11986:SF79	ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04397	p53 pathway by glucose deprivation	P04641	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01438	PP2A	TRIAD|EnsemblGenome=TriadG63380|UniProtKB=B3S653	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00780	Microtubule	PANTR|Ensembl=ENSPTRG00000013680|UniProtKB=H2QKN9	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF112	TUBULIN BETA-1 CHAIN
P00057	Wnt signaling pathway	P01435	SWI/SNF	RAT|RGD=621728|UniProtKB=Q8K1P7	Transcription activator BRG1	ISS	11532957	PubMed	PTHR10799:SF76	TRANSCRIPTION ACTIVATOR BRG1
P00019	Endothelin signaling pathway	P00589	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	NAS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01227	20S proteasome	ORNAN|Ensembl=ENSOANG00000014057|UniProtKB=F7C9K3	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF11	PROTEASOME SUBUNIT ALPHA TYPE-6
P06664	Gonadotropin-releasing hormone receptor pathway	P06841	gnaq/11	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	RCA	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00045	Notch signaling pathway	P01099	Notch	CANLF|Ensembl=ENSCAFG00000019633|UniProtKB=F1PDC7	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00005	Angiogenesis	P00253	Axin	MACMU|Ensembl=ENSMMUG00000000605|UniProtKB=F6Y8V8	Uncharacterized protein	ISS	9554852	PubMed	PTHR10845:SF11	AXIN-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00048	PI3 kinase pathway	P01179	PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00037	Ionotropic glutamate receptor pathway	P01026	KA	CANLF|Ensembl=ENSCAFG00000004930|UniProtKB=E2RFB5	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	CHICK|Ensembl=ENSGALG00000001569|UniProtKB=Q9PSX7	Rho-related GTP-binding protein RhoC	ISS	12090470	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01153	GSK3	PANTR|Ensembl=ENSPTRG00000006335|UniProtKB=H2Q8A2	Uncharacterized protein	ISS			PTHR18905:SF11	NINEIN
P00053	T cell activation	P01305	Calmodulin	CANLF|Ensembl=ENSCAFG00000017516|UniProtKB=E2REK6	Uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF311	CALMODULIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00113	Erb-B4 transmembrane fragment	MONDO|Ensembl=ENSMODG00000015755|UniProtKB=F6ZSZ9	Uncharacterized protein (Fragment)	ISS	4884676	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00029	Huntington disease	P00787	MAPKK4	BOVIN|Ensembl=ENSBTAG00000012103|UniProtKB=A5PJP8	MAP2K4 protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00048	PI3 kinase pathway	P01194	S6K	BOVIN|Gene=RPS6KB1|UniProtKB=Q6TJY3	Ribosomal protein S6 kinase beta-1	ISS	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00019	Endothelin signaling pathway	P00568	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CANLF|Ensembl=ENSCAFG00000005662|UniProtKB=E2R907	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	ARATH|TAIR=AT5G63310|UniProtKB=O64903	Nucleoside diphosphate kinase II, chloroplastic	ISS			PTHR11349:SF44	NUCLEOSIDE DIPHOSPHATE KINASE II, CHLOROPLASTIC
P00056	VEGF signaling pathway	P01423	p38MAPK	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	CAEBR|Gene=CBG14305|UniProtKB=A8XJQ6	cAMP-dependent protein kinase, catalytic subunit-like	ISS	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00006	Apoptosis signaling pathway	P00300	Caspase 7	PANTR|Ensembl=ENSPTRG00000002952|UniProtKB=H2Q2L2	Uncharacterized protein	ISS	14583630	PubMed	PTHR10454:SF31	CASPASE-7
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	HUMAN|HGNC=28114|UniProtKB=Q8IZ83	Aldehyde dehydrogenase family 16 member A1	IC			PTHR11699:SF98	ALDEHYDE DEHYDROGENASE FAMILY 16 MEMBER A1
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00034	Integrin signalling pathway	P00951	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01163	c-Jun	XENTR|Xenbase=XB-GENE-482228|UniProtKB=F6RYL1	Uncharacterized protein	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12805548	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	XENTR|Xenbase=XB-GENE-945015|UniProtKB=F6QA46	Uncharacterized protein	ISS	1354612	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00111	C99	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00029	Huntington disease	P00810	GAPDH	DROME|FlyBase=FBgn0001092|UniProtKB=P07487	Glyceraldehyde-3-phosphate dehydrogenase 2	ISS			PTHR10836:SF52	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01095	beta	MOUSE|MGI=MGI=87891|UniProtKB=Q9ERK7	Neuronal acetylcholine receptor subunit beta-2	ISS	15155845	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P00006	Apoptosis signaling pathway	P00289	FAS	RAT|RGD=619831|UniProtKB=Q63199	Tumor necrosis factor receptor superfamily member 6	ISS	14585074	PubMed	PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00047	PDGF signaling pathway	P01153	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ORNAN|Ensembl=ENSOANG00000007581|UniProtKB=F6QWB7	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00966	mTOR	PANTR|Ensembl=ENSPTRG00000000142|UniProtKB=H2PY03	Uncharacterized protein	ISS	8662507	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P05734	Synaptic vesicle trafficking	P05777	Synaptophysin	RAT|RGD=3802|UniProtKB=P07825	Synaptophysin	ISS	313475	OMIM	PTHR10306:SF10	SYNAPTOPHYSIN
P00025	Hedgehog signaling pathway	P00682	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00018	EGF receptor signaling pathway	P00555	MKK4,7	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	FUSNN|EnsemblGenome=FN0452|UniProtKB=Q8RG65	Glutamine--fructose-6-phosphate aminotransferase [isomerizing]	ISS			PTHR10937:SF0	GH12731P-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000009085|UniProtKB=H2RDQ2	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00010	B cell activation	P00379	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IDA	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00019	Endothelin signaling pathway	P00587	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=2685011|UniProtKB=E9PVD3	Protocadherin-16	ISS	8120095	PubMed	PTHR43956:SF6	PROTOCADHERIN-16
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01390	TFIIA complex	ARATH|TAIR=AT1G07480|UniProtKB=O49349	AT1G07480 protein	ISS	600519	OMIM	PTHR12694:SF13	TFIIA-L3
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	ANOGA|EnsemblGenome=AGAP002262|UniProtKB=Q7QKC3	AGAP002262-PA	ISS			PTHR11920:SF453	ADENYLYL CYCLASE 78C, ISOFORM E
P05918	p38 MAPK pathway	P06021	Rac	ORNAN|Ensembl=ENSOANG00000013618|UniProtKB=F7FH99	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P06212	DPP-SCW signaling pathway	P06269	LACK	DROME|FlyBase=FBgn0029006|UniProtKB=Q9V853	E3 ubiquitin-protein ligase Smurf1	IEA	http://flybase.org/reports/FBgn0029006.html	Website	PTHR11254:SF395	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04393	Ras Pathway	P04570	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00047	PDGF signaling pathway	P01150	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	TAKRU|Ensembl=ENSTRUG00000007253|UniProtKB=H2SZQ1	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04393	Ras Pathway	P04559	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00015	Circadian clock system	P00505	Cry	CANLF|Ensembl=ENSCAFG00000001797|UniProtKB=E2RMX4	Uncharacterized protein	ISS	10428031	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00057	Wnt signaling pathway	P01440	Cadherin	XENTR|Xenbase=XB-GENE-482277|UniProtKB=F6QAX3	Uncharacterized protein	ISS	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00081	Pro-BACE-1	PANTR|Ensembl=ENSPTRG00000013924|UniProtKB=H2R1L7	Beta-site APP-cleaving enzyme 2	ISS			PTHR13683:SF262	BETA-SECRETASE 2
P00053	T cell activation	P01332	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CANLF|Ensembl=ENSCAFG00000013148|UniProtKB=Q5R1P3	Glutamate receptor ionotropic, NMDA 2B	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000002339|UniProtKB=H2R368	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00048	PI3 kinase pathway	P01202	p85	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00010	B cell activation	P00391	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00182	p38MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00036	Interleukin signaling pathway	P00974	Receptor subunit beta	MOUSE|MGI=MGI=1339759|UniProtKB=P26955	Cytokine receptor common subunit beta	ISS	1386365	PubMed	PTHR23037:SF22	CYTOKINE RECEPTOR COMMON SUBUNIT BETA
P00046	Oxidative stress response	P01133	Max	RAT|RGD=621101|UniProtKB=P52164	Protein max	TAS	11274345	PubMed	PTHR10328:SF3	PROTEIN MAX
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IC	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00981	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	MOUSE|MGI=MGI=1346037|UniProtKB=Q9WTL4	Insulin receptor-related protein	ISS	6754360	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ARATH|TAIR=AT3G05530|UniProtKB=Q9SEI2	26S protease regulatory subunit 6A homolog A	ISS			PTHR23073:SF7	26S PROTEASE REGULATORY SUBUNIT 6A
P00036	Interleukin signaling pathway	P00973	PKB	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01349	ECSIT	MACMU|Ensembl=ENSMMUG00000020618|UniProtKB=F7BSY7	Uncharacterized protein	ISS			PTHR13113:SF1	EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAY, MITOCHONDRIAL
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00021	FGF signaling pathway	P00627	ERK1-2	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	IC	1319556	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00048	PI3 kinase pathway	P01199	Galpha	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=1309895|UniProtKB=G3V8N7	Protein Pcdhb8	ISS	8120095	PubMed	PTHR24028:SF100	MCG141292-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=98958|UniProtKB=P22725	Protein Wnt-5a	TAS	11266476	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00048	PI3 kinase pathway	P01200	SHIP	HUMAN|HGNC=6080|UniProtKB=O15357	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	IC	10610720	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05917	Opioid proopiomelanocortin pathway	P06009	K+ channel	RAT|RGD=61997|UniProtKB=O54912	Potassium channel subfamily K member 3	ISS	11875121	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00059	p53 pathway	P04630	PP2A	TAKRU|Ensembl=ENSTRUG00000011169|UniProtKB=H2TU36	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00568	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00052	TGF-beta signaling pathway	P01275	P38	DROME|FlyBase=FBgn0015765|UniProtKB=O62618	Mitogen-activated protein kinase 14A	TAS	11707292	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05941	GRK3	XENTR|Ensembl=ENSXETG00000030841|UniProtKB=F7C5A3	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF18	PROTEIN-SERINE/THREONINE KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	TAS			PTHR10048:SF14	PI-3 KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04558	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00547	PP2A	DROME|FlyBase=FBgn0052568|UniProtKB=Q9VXB7	Uncharacterized protein, isoform B	ISS			PTHR10257:SF29	BCDNA.LD34343
P00034	Integrin signalling pathway	P00913	Csk	HUMAN|HGNC=2444|UniProtKB=P41240	Tyrosine-protein kinase CSK	IDA	11078745	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MOUSE|MGI=MGI=95816|UniProtKB=B1AS29	Glutamate receptor ionotropic, kainate 3	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P05917	Opioid proopiomelanocortin pathway	P06009	K+ channel	BOVIN|Ensembl=ENSBTAG00000018193|UniProtKB=E1BHX8	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00021	FGF signaling pathway	P00638	PLCgamma	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	MOUSE|MGI=MGI=94924|UniProtKB=P61168	D(2) dopamine receptor	RCA	11248120	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04586	ProTRH (Pro Thyrotropin-releasing Hormone)	PANTR|Ensembl=ENSPTRG00000018398|UniProtKB=H2QTD1	Glycoprotein hormones alpha chain	ISS			PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P05913	Enkephalin release	P05977	G-Protein (s)	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04393	Ras Pathway	P04546	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00019	Endothelin signaling pathway	P00591	PLCbeta	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00037	Ionotropic glutamate receptor pathway	P01005	NR2D	HUMAN|HGNC=4588|UniProtKB=O15399	Glutamate receptor ionotropic, NMDA 2D	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2D.html	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00057	Wnt signaling pathway	P01437	TCF	MONDO|Ensembl=ENSMODG00000015573|UniProtKB=F7AIP6	Uncharacterized protein (Fragment)	ISS	11266476	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00034	Integrin signalling pathway	P00925	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00828	Galphai	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	RCA			PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	DANRE|ZFIN=ZDB-GENE-051202-1|UniProtKB=E7F101	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF2	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	PANTR|Ensembl=ENSPTRG00000034127|UniProtKB=H2RDU2	Uncharacterized protein	ISS	10934230	PubMed	PTHR24230:SF8	LEUKOTRIENE B4 RECEPTOR 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00049	Parkinson disease	P01227	20S proteasome	SCHPO|PomBase=SPAC13C5.01c|UniProtKB=Q09682	Probable proteasome subunit alpha type-3	TAS	12859888	PubMed	PTHR11599:SF13	PROTEASOME SUBUNIT ALPHA TYPE-4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00034	Integrin signalling pathway	P00906	Rap1	ORNAN|Ensembl=ENSOANG00000011699|UniProtKB=F7A1D4	Uncharacterized protein	ISS	8576107	PubMed	PTHR24070:SF200	RAS-RELATED PROTEIN RAP-2C
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	BOVIN|Ensembl=ENSBTAG00000000219|UniProtKB=F1MCL3	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00552	Ras	CAEEL|WormBase=WBGene00002335|UniProtKB=P22981	Ras protein let-60	IGI	22022015	PubMed	PTHR24070:SF385	GTPASE HRAS
P00052	TGF-beta signaling pathway	P01275	P38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00034	Integrin signalling pathway	P00907	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000005917|UniProtKB=F6QM53	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00029	Huntington disease	P00778	NMDA receptor	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01182	Ras	XENTR|Xenbase=XB-GENE-494548|UniProtKB=F7EC26	Uncharacterized protein	ISS	10825661	PubMed	PTHR24070:SF186	GTPASE KRAS
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	MACMU|Ensembl=ENSMMUG00000022872|UniProtKB=F6WMJ4	Low-density lipoprotein receptor-related protein 3	ISS	11907044	PubMed	PTHR44062:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 3
P02730	Asparagine and aspartate biosynthesis	P02853	Asparagine synthetase	ANOGA|EnsemblGenome=AGAP003833|UniProtKB=Q7QFU7	AGAP003833-PA	ISS			PTHR11772:SF2	ASPARAGINE SYNTHETASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00046	Oxidative stress response	P01135	p38	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	TAS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00057	Wnt signaling pathway	P01443	Phospholipase C	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	HUMAN|HGNC=3955|UniProtKB=P42685	Tyrosine-protein kinase FRK	ISS			PTHR24418:SF296	TYROSINE-PROTEIN KINASE FRK
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04393	Ras Pathway	P04558	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	XENTR|Ensembl=ENSXETG00000021375|UniProtKB=F6T423	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	MONDO|Ensembl=ENSMODG00000021239|UniProtKB=F6TZU4	Uncharacterized protein	ISS	11055438	PubMed	PTHR10117:SF56	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000000440|UniProtKB=H2PYH8	Uncharacterized protein	ISS	11259498	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IC	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00012	Cadherin signaling pathway	P00464	Fyn	XENTR|Xenbase=XB-GENE-6053489|UniProtKB=F6S8L5	Tyrosine-protein kinase	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00021	FGF signaling pathway	P00638	PLCgamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IGI	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000000289|UniProtKB=F7A9T0	Uncharacterized protein	ISS	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00010	B cell activation	P00398	IP3R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	IGI	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00110	Ire-1 N-terminal fragment	ARATH|TAIR=AT5G24360|UniProtKB=Q93VJ2	Serine/threonine-protein kinase/endoribonuclease IRE1b	IDA	10619423	PubMed	PTHR13954:SF13	SERINE/THREONINE-PROTEIN KINASE/ENDORIBONUCLEASE IRE1B
P00029	Huntington disease	P00805	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00630	RKIP	DROME|FlyBase=FBgn0032453|UniProtKB=Q9VK60	CG6180	ISS			PTHR11362:SF28	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05915	Opioid proenkephalin pathway	P05994	G-protein	HUMAN|HGNC=19663|UniProtKB=Q9UBI6	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00034	Integrin signalling pathway	P00922	Collagen	PANTR|Ensembl=ENSPTRG00000001017|UniProtKB=H2PZI3	Uncharacterized protein	ISS	10778855	PubMed	PTHR24023:SF42	COLLAGEN ALPHA-1 XI  CHAIN
P00018	EGF receptor signaling pathway	P00551	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	IGI	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	88107662	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00236	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05959	FLNA	MACMU|Ensembl=ENSMMUG00000013668|UniProtKB=F7GCM2	Uncharacterized protein	ISS	9722563	PubMed	PTHR43998:SF6	FILAMIN-A
P00007	Axon guidance mediated by semaphorins	P00340	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	10540223	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	PANTR|Ensembl=ENSPTRG00000001477|UniProtKB=H2Q0A5	Tyrosine-protein kinase receptor	ISS	10226785	PubMed	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P05731	GABA-B receptor II signaling	P05752	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00010	B cell activation	P00398	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00034	Integrin signalling pathway	P00925	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8440264	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00024	Glycolysis	P00678	Enolase	XENTR|Xenbase=XB-GENE-483500|UniProtKB=B0BMH7	Eno1 protein	ISS	89079778	PubMed	PTHR11902:SF12	ALPHA-ENOLASE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04395	Vasopressin synthesis	P04596	Endo Peptidase	PSEAE|EnsemblGenome=PA1304|UniProtKB=Q9I440	Probable oligopeptidase	IC			PTHR11757:SF3	PROTEASE 2
P00048	PI3 kinase pathway	P01199	Galpha	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	IC	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	IC	14744463	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	BOVIN|Ensembl=ENSBTAG00000011757|UniProtKB=Q9XT97	Presenilin-1	TAS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT1G10210|UniProtKB=Q39021	Mitogen-activated protein kinase 1	ISS	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00047	PDGF signaling pathway	P01168	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00018	EGF receptor signaling pathway	P00547	PP2A	PANTR|Ensembl=ENSPTRG00000018180|UniProtKB=H2QT14	Protein phosphatase 2, regulatory subunit B', delta	ISS	12110603	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00006	Apoptosis signaling pathway	P00297	NFkappaB	RAT|RGD=70498|UniProtKB=Q63369	Nuclear factor NF-kappa-B p105 subunit (Fragment)	ISS	11739545	PubMed	PTHR24169:SF9	NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT
P00020	FAS signaling pathway	P00607	Pro-Caspase6	CHICK|Ensembl=ENSGALG00000012186|UniProtKB=F1NEL6	Uncharacterized protein	IGI	11463840	PubMed	PTHR10454:SF164	CASPASE-6
P00049	Parkinson disease	P01208	Hsp70	ARATH|TAIR=AT1G56410|UniProtKB=Q9C7X7	Heat shock 70 kDa protein 18	IDA	12150907	PubMed	PTHR19375:SF323	HEAT SHOCK 70 KDA PROTEIN 18-RELATED
P00005	Angiogenesis	P00249	PAK	BOVIN|Ensembl=ENSBTAG00000015670|UniProtKB=E1B7J7	Uncharacterized protein	ISS	7559398	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	2574500	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P02785	Valine biosynthesis	P03216	Acetolactate synthase	ORYSJ|Gene=Os02g0510200|UniProtKB=Q6K2E8	Acetolactate synthase 1, chloroplastic	ISS			PTHR18968:SF112	ACETOLACTATE SYNTHASE, CHLOROPLASTIC
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2846|UniProtKB=P28564	5-hydroxytryptamine receptor 1B	IDA	11701344	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CHICK|Ensembl=ENSGALG00000009844|UniProtKB=P68034	Actin, alpha cardiac muscle 1	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00049	Parkinson disease	P01238	14-3-3	BOVIN|Gene=YWHAB|UniProtKB=P68250	14-3-3 protein beta/alpha	IDA	10407019	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	HUMAN|HGNC=1402|UniProtKB=Q08289	Voltage-dependent L-type calcium channel subunit beta-2	IC	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00046	Oxidative stress response	P01129	JNK1/2	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00572	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IGI	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	DICDI|dictyBase=DDB_G0292736|UniProtKB=Q02158	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS			PTHR10336:SF105	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	CANLF|Ensembl=ENSCAFG00000010255|UniProtKB=E2RPY4	Uncharacterized protein	ISS			PTHR11767:SF52	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 4
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	ECOLI|EcoGene=EG11002|UniProtKB=P0A884	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_127488|UniProtKB=C3XYC7	Putative uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00012	Cadherin signaling pathway	P00477	GSK3beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	PANTR|Ensembl=ENSPTRG00000012547|UniProtKB=H2QIU3	Uncharacterized protein	ISS	12374786	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00005	Angiogenesis	P00182	p38MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00047	PDGF signaling pathway	P01168	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04395	Vasopressin synthesis	P04589	Signal Peptidase	CAEEL|WormBase=WBGene00019679|UniProtKB=P34525	Probable signal peptidase complex subunit 3	IC	1546959	PubMed	PTHR12804:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 3
P00034	Integrin signalling pathway	P00927	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00021	FGF signaling pathway	P00641	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00005	Angiogenesis	P00236	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	TAS	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00047	PDGF signaling pathway	P01154	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IC	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00049	Parkinson disease	P01208	Hsp70	XENTR|Xenbase=XB-GENE-955426|UniProtKB=F6QKL0	Uncharacterized protein (Fragment)	ISS	12150907	PubMed	PTHR19375:SF239	HEAT SHOCK COGNATE 71 KDA PROTEIN
P00010	B cell activation	P00376	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MONDO|Ensembl=ENSMODG00000001303|UniProtKB=F7BZM9	Uncharacterized protein (Fragment)	ISS	12932731	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00005	Angiogenesis	P00254	GTPase	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	ISS	11360179	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P02738	De novo purine biosynthesis	P02906	N5-carboxyaminoimidazole ribonucleotide synthase	LEPIN|EnsemblGenome=LA_1463|UniProtKB=Q8F649	N5-carboxyaminoimidazole ribonucleotide mutase	ISS			PTHR23046:SF2	N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE MUTASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00238	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00056	VEGF signaling pathway	P01419	Ets	MONDO|Ensembl=ENSMODG00000004730|UniProtKB=F6Y1Z2	Uncharacterized protein	ISS	9157999	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P02741	Flavin biosynthesis	P02935	GTP cyclohydrolase	RHOBA|EnsemblGenome=RB12480|UniProtKB=Q7UIK1	GTP cyclohydrolase-2	ISS			PTHR21327:SF32	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	HUMAN|HGNC=9441|UniProtKB=P51817	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00047	PDGF signaling pathway	P01160	IP3 receptor	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00050	Plasminogen activating cascade	P01251	MMP-3	RAT|RGD=621317|UniProtKB=P03957	Stromelysin-1	IEP	3875482	PubMed	PTHR10201:SF215	STROMELYSIN-1
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=2136760|UniProtKB=Q91XZ8	Protein Pcdhb22	IDA	8120095	PubMed	PTHR24028:SF97	PROTOCADHERIN BETA-15
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00010	B cell activation	P00402	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00019	Endothelin signaling pathway	P00591	PLCbeta	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	ISS	12001934	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IGI	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P02746	Heme biosynthesis	P02975	Uroporphyrinogen decarboxylase	BOVIN|Ensembl=ENSBTAG00000012644|UniProtKB=E1BEX4	Uroporphyrinogen decarboxylase	ISS			PTHR21091:SF2	UROPORPHYRINOGEN DECARBOXYLASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00029	Huntington disease	P00786	ARF	DICPU|Gene=DICPUDRAFT_93077|UniProtKB=F1A1N6	ADP-ribosylation factor 1	ISS	12932731	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MONDO|Ensembl=ENSMODG00000017213|UniProtKB=F6WYK8	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00021	FGF signaling pathway	P00638	PLCgamma	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00718	Phosphorylase a	RAT|RGD=3461|UniProtKB=P09812	Glycogen phosphorylase, muscle form	IDA	4318782	PubMed	PTHR11468:SF13	GLYCOGEN PHOSPHORYLASE, MUSCLE FORM
P02757	O-antigen biosynthesis	P03045	dTDP-glucose 4,6-dehydratase	MACMU|Ensembl=ENSMMUG00000013063|UniProtKB=F7H5H9	Uncharacterized protein	ISS			PTHR43000:SF7	DTDP-D-GLUCOSE 4,6-DEHYDRATASE
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MACMU|Ensembl=ENSMMUG00000000042|UniProtKB=F7HPH2	Serine/threonine-protein kinase receptor	ISS	9395284	PubMed	PTHR23255:SF64	ACTIVIN RECEPTOR TYPE-2A
P00036	Interleukin signaling pathway	P00983	Raf	MOUSE|MGI=MGI=88190|UniProtKB=P28028	Serine/threonine-protein kinase B-raf	ISS	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00020	FAS signaling pathway	P00620	CytochromeC	CHLRE|EnsemblGenome=CHLREDRAFT_133395|UniProtKB=A8JIU5	Ubiquinol:cytochrome c oxidoreductase cytochrome c1	IGI	15163634	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P02775	Salvage pyrimidine ribonucleotides	P03156	CDP kinase	YEAST|SGD=S000005295|UniProtKB=P27515	Uridine kinase	ISS			PTHR10285:SF123	URIDINE KINASE
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00047	PDGF signaling pathway	P01153	GSK3	PANTR|Ensembl=ENSPTRG00000011049|UniProtKB=H2QGF9	Glycogen synthase kinase 3 alpha	ISS	183955	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00048	PI3 kinase pathway	P01179	PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	PANTR|Ensembl=ENSPTRG00000006342|UniProtKB=H2Q8A8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P05731	GABA-B receptor II signaling	P05760	AC	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00019	Endothelin signaling pathway	P00566	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00022	General transcription by RNA polymerase I	P00651	TAF-IA	ARATH|TAIR=AT3G02160|UniProtKB=Q9S7R9	At3g02160	ISS			PTHR12321:SF53	BROMODOMAIN TRANSCRIPTION FACTOR
P04393	Ras Pathway	P04564	MAPKAP	MACMU|Ensembl=ENSMMUG00000023567|UniProtKB=F7HHY8	Uncharacterized protein	ISS	7923354	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00046	Oxidative stress response	P01131	MKP5	CAEEL|WormBase=WBGene00006923|UniProtKB=Q10038	Tyrosine-protein phosphatase vhp-1	ISS			PTHR10159:SF343	TYROSINE-PROTEIN PHOSPHATASE VHP-1
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	RAT|RGD=62030|UniProtKB=P02564	Myosin-7	ISS	89264452	PubMed	PTHR13140:SF344	MYOSIN-7
P00057	Wnt signaling pathway	P01451	Galpha	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00577	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P00034	Integrin signalling pathway	P00925	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02751	Lysine biosynthesis	P03008	Dihydrodipicolinate synthase	METAC|EnsemblGenome=MA_4473|UniProtKB=Q8THP1	4-hydroxy-tetrahydrodipicolinate synthase	ISS			PTHR12128:SF15	4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	XENTR|Xenbase=XB-GENE-959791|UniProtKB=F7E7R1	Fructose-bisphosphate aldolase (Fragment)	ISS	9427528	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00021	FGF signaling pathway	P00629	PP2A	HUMAN|HGNC=9299|UniProtKB=P67775	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00036	Interleukin signaling pathway	P00965	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00242	TCF	MOUSE|MGI=MGI=1202879|UniProtKB=Q924A0	Transcription factor 7-like 2	ISS	9118222	PubMed	PTHR10373:SF32	TRANSCRIPTION FACTOR 7-LIKE 2
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000011757|UniProtKB=Q9XT97	Presenilin-1	IDA	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	8787761	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00591	PLCbeta	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MONDO|Ensembl=ENSMODG00000004799|UniProtKB=F6VM87	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00057	Wnt signaling pathway	P01444	Wnt	MACMU|Ensembl=ENSMMUG00000001325|UniProtKB=F7BGU5	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00056	VEGF signaling pathway	P01411	Ras	MONDO|Gene=KRAS|UniProtKB=Q07983	GTPase KRas	ISS	3023884	PubMed	PTHR24070:SF186	GTPASE KRAS
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	MONDO|Ensembl=ENSMODG00000009266|UniProtKB=F7DA21	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF27	G PROTEIN-COUPLED RECEPTOR KINASE 5
P05918	p38 MAPK pathway	P06015	p38gamma	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04665	AKT	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	12086862	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02738	De novo purine biosynthesis	P02891	GDP kinase	MOUSE|MGI=MGI=97355|UniProtKB=P15532	Nucleoside diphosphate kinase A	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	DANRE|ZFIN=ZDB-GENE-990415-166|UniProtKB=P79737	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	CHICK|Ensembl=ENSGALG00000008898|UniProtKB=F1P2J9	Uncharacterized protein	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00021	FGF signaling pathway	P00641	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02746	Heme biosynthesis	P02983	Hydroxymethylbilane synthase	RAT|RGD=2801|UniProtKB=P19356	Porphobilinogen deaminase	ISS			PTHR11557:SF0	PORPHOBILINOGEN DEAMINASE
P00021	FGF signaling pathway	P00624	14-3-3	MONDO|Ensembl=ENSMODG00000010174|UniProtKB=F6TA21	Uncharacterized protein	ISS	12917326	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04427	5HT4 Receptor	BOVIN|Ensembl=ENSBTAG00000010837|UniProtKB=F1N3N9	Uncharacterized protein	ISS	12441358	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P00049	Parkinson disease	P01237	Complex I	PANTR|Ensembl=ENSPTRG00000009856|UniProtKB=Q0MQI9	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	ISS	3100899	PubMed	PTHR10371:SF3	NADH DEHYDROGENASE  UBIQUINONE  FLAVOPROTEIN 2, MITOCHONDRIAL
P00005	Angiogenesis	P00203	Erk	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00546	GAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	2574500	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Ensembl=ENSPTRG00000018449|UniProtKB=H2QTG5	Uncharacterized protein	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	BOVIN|Ensembl=ENSBTAG00000018989|UniProtKB=A5D7D8	GRM3 protein	ISS			PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00011	Blood coagulation	P00443	Fibrin polymer cross-linked	HUMAN|HGNC=3661|UniProtKB=P02671	Fibrinogen alpha chain	ISS	4503689	gi	PTHR19143:SF232	FIBRINOGEN ALPHA CHAIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04453	ACTH	HUMAN|HGNC=9201|UniProtKB=P01189	Pro-opiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00009	Axon guidance mediated by netrin	P00357	Netrin	BOVIN|Ensembl=ENSBTAG00000045625|UniProtKB=G3N0E7	Netrin 3	ISS			PTHR10574:SF292	NETRIN-3
P00056	VEGF signaling pathway	P01404	SPK	MOUSE|MGI=MGI=1316649|UniProtKB=Q8CI15	Sphingosine kinase 1	ISS			PTHR12358:SF47	SPHINGOSINE KINASE 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00021	FGF signaling pathway	P00644	p38	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	IGI	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00054	Toll receptor signaling pathway	P01375	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MACMU|Ensembl=ENSMMUG00000002134|UniProtKB=F6UNV6	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00057	Wnt signaling pathway	P01463	Kremen	RAT|RGD=620789|UniProtKB=Q924S4	Kremen protein 1	ISS			PTHR24269:SF13	KREMEN PROTEIN 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00009	Axon guidance mediated by netrin	P00364	cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04395	Vasopressin synthesis	P04593	Glycopeptide	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	IC	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00029	Huntington disease	P00792	SEK-1	HUMAN|HGNC=6844|UniProtKB=P45985	Dual specificity mitogen-activated protein kinase kinase 4	RCA			PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00034	Integrin signalling pathway	P00931	Integrin beta	CAEEL|WormBase=WBGene00003930|UniProtKB=Q27874	Integrin beta pat-3	IDA	3487386	PubMed	PTHR10082:SF41	INTEGRIN BETA-PS
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MONDO|Ensembl=ENSMODG00000005623|UniProtKB=F7CFG8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00025	Hedgehog signaling pathway	P00682	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00297	NFkappaB	CANLF|Ensembl=ENSCAFG00000013334|UniProtKB=F1PCU1	Uncharacterized protein	ISS	10049353	PubMed	PTHR24169:SF1	TRANSCRIPTION FACTOR P65
P00059	p53 pathway	P01480	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000001384|UniProtKB=F7GL73	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05731	GABA-B receptor II signaling	P05760	AC	HUMAN|HGNC=239|UniProtKB=P40145	Adenylate cyclase type 8	RCA	2491850	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00048	PI3 kinase pathway	P01182	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00034	Integrin signalling pathway	P00910	Grb2	DANRE|ZFIN=ZDB-GENE-040426-1975|UniProtKB=Q6PC73	Growth factor receptor-bound protein 2	ISS	4504111	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P06664	Gonadotropin-releasing hormone receptor pathway	P06851	ER	MOUSE|MGI=MGI=1346831|UniProtKB=O08580	Steroid hormone receptor ERR1	RCA			PTHR24084:SF27	STEROID HORMONE RECEPTOR ERR1
P00034	Integrin signalling pathway	P00928	alpha actinin	HUMAN|HGNC=163|UniProtKB=P12814	Alpha-actinin-1	IPI	2116421	PubMed	PTHR43947:SF3	ALPHA-ACTININ-1
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	RAT|RGD=1560083|UniProtKB=D3ZZK7	Protein Myo3a	ISS	22028976	PubMed	PTHR13140:SF387	MYOSIN-IIIA
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_114535|UniProtKB=C3ZHN2	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00049	Parkinson disease	P01234	GRK	CHICK|Ensembl=ENSGALG00000005518|UniProtKB=F1NTL1	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	IDA	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00057	Wnt signaling pathway	P01444	Wnt	RAT|RGD=1309574|UniProtKB=D3ZFS0	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF84	PROTEIN WNT-9B
P02785	Valine biosynthesis	P03218	Dihydroxy isovalerate dehydratase	METAC|EnsemblGenome=MA_1802|UniProtKB=Q8TPV2	Dihydroxy-acid dehydratase 1	ISS			PTHR43661:SF3	DIHYDROXY-ACID DEHYDRATASE
P00056	VEGF signaling pathway	P01417	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00587	Raf-1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176910	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00017	DNA replication	P00536	DNA Topisomerase	LEIMA|EnsemblGenome=LmjF.28.2280|UniProtKB=Q4Q836	DNA topoisomerase 2	ISS			PTHR10169:SF38	DNA TOPOISOMERASE 2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DROME|FlyBase=FBgn0000043|UniProtKB=P02572	Actin-42A	ISS	10974003	PubMed	PTHR11937:SF369	ACTIN-42A
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IDA	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00029	Huntington disease	P00807	Actin	PHYIT|EnsemblGenome=PITG_15117|UniProtKB=D0NRP9	Actin-like protein	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00059	p53 pathway	G01581	BAX	XENTR|Xenbase=XB-GENE-486067|UniProtKB=Q6P4Y4	BCL2-associated X protein	ISS	11099028	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P00019	Endothelin signaling pathway	P00589	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01407	Erk	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00045	Notch signaling pathway	P01101	Su(H)	ORNAN|Ensembl=ENSOANG00000006699|UniProtKB=F6ULE6	Uncharacterized protein	ISS	9043084	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	THEKO|EnsemblGenome=TK2287|UniProtKB=P58109	Transcription initiation factor IIB 2	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	EMENI|EnsemblGenome=CADANIAG00002125|UniProtKB=P08157	Aldehyde dehydrogenase	IC			PTHR11699:SF211	ALDEHYDE DEHYDROGENASE 5, MITOCHONDRIAL
P00057	Wnt signaling pathway	P01428	Frizzled	MOUSE|MGI=MGI=108571|UniProtKB=Q9EQD0	Frizzled-5	IDA	8717036	PubMed	PTHR11309:SF126	FRIZZLED-5
P00047	PDGF signaling pathway	P01167	Ets	BOVIN|Ensembl=ENSBTAG00000019043|UniProtKB=Q0VC98	GA binding protein transcription factor, alpha subunit 60kDa	ISS	15298723	PubMed	PTHR11849:SF195	GA-BINDING PROTEIN ALPHA CHAIN
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00047	PDGF signaling pathway	P01174	Rho	MOUSE|MGI=MGI=2151070|UniProtKB=Q99J31	Oligophrenin-1	ISS			PTHR12552:SF2	OLIGOPHRENIN-1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	CRYNJ|EnsemblGenome=CND03830|UniProtKB=Q5KI86	Uncharacterized protein	ISS	10594037	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00001	Adrenaline and noradrenaline biosynthesis	P00071	VAT1	PANTR|Ensembl=ENSPTRG00000020039|UniProtKB=H2R9W1	Uncharacterized protein	ISS	11443533	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MONDO|Ensembl=ENSMODG00000020204|UniProtKB=F6SED9	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00012	Cadherin signaling pathway	P00471	Cadherin	BOVIN|Gene=CDH13|UniProtKB=Q3B7N0	Cadherin-13	ISS	8120095	PubMed	PTHR24027:SF80	CADHERIN-13
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	IDA	15621031	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P05731	GABA-B receptor II signaling	P05753	Ca channel	RAT|RGD=68942|UniProtKB=O54898	Voltage-dependent T-type calcium channel subunit alpha-1G	ISS	14526084	PubMed	PTHR10037:SF137	VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1G
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04393	Ras Pathway	P04558	p38	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00005	Angiogenesis	P00214	HIF-1	MOUSE|MGI=MGI=106918|UniProtKB=Q61221	Hypoxia-inducible factor 1-alpha	ISS	14526383	PubMed	PTHR23043:SF7	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=24772|UniProtKB=Q8IX94	cTAGE family member 4	IC			PTHR23158:SF53	CTAGE FAMILY MEMBER 15-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	IC	2837282	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00057	Wnt signaling pathway	P01465	Ggamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00005	Angiogenesis	P00253	Axin	HUMAN|HGNC=903|UniProtKB=O15169	Axin-1	IDA	9554852	PubMed	PTHR10845:SF11	AXIN-1
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00047	PDGF signaling pathway	P01151	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00388	PLC gamma2	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MONDO|Ensembl=ENSMODG00000001389|UniProtKB=F7BD45	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF657	MYOSIN-4
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00020	FAS signaling pathway	P00615	JNK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	TAS	11707292	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01446	Calcineurin	MOUSE|MGI=MGI=107162|UniProtKB=P48455	Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform	IDA	12015605	PubMed	PTHR11668:SF186	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT GAMMA ISOFORM
P00059	p53 pathway	G04694	p110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00047	PDGF signaling pathway	P01160	IP3 receptor	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00005	Angiogenesis	P00249	PAK	HUMAN|HGNC=8592|UniProtKB=O75914	Serine/threonine-protein kinase PAK 3	ISS	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00010	B cell activation	P00391	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00005	Angiogenesis	P00227	PLA2	CANLF|Ensembl=ENSCAFG00000013778|UniProtKB=F6UQ33	Phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01095	beta	CAEEL|WormBase=WBGene00000042|UniProtKB=P48182	Acetylcholine receptor subunit beta-type acr-2	ISS	22213672	PubMed	PTHR18945:SF744	ACETYLCHOLINE RECEPTOR SUBUNIT BETA-TYPE ACR-2
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	DROME|FlyBase=FBgn0032002|UniProtKB=Q9VLR2	CG8353, isoform A	ISS			PTHR11644:SF2	CYTIDINE DEAMINASE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	ANOGA|EnsemblGenome=AGAP005913|UniProtKB=Q7Q6D2	AGAP005913-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	ARATH|TAIR=AT5G26751|UniProtKB=P43288	Shaggy-related protein kinase alpha	TAS			PTHR24057:SF13	SHAGGY-RELATED PROTEIN KINASE ALPHA-RELATED
P00036	Interleukin signaling pathway	P00964	p90RSK	RAT|RGD=1563860|UniProtKB=D3Z8E0	Ribosomal protein S6 kinase	ISS	2779569	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000008205|UniProtKB=H2QBA3	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF1	CADHERIN-16
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00015	Circadian clock system	G01497	cry	ORNAN|Ensembl=ENSOANG00000005350|UniProtKB=F6X852	Uncharacterized protein	ISS	11804325	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00008	Axon guidance mediated by Slit/Robo	P00348	Robo	DANRE|ZFIN=ZDB-GENE-000209-4|UniProtKB=F1QFK4	Uncharacterized protein	ISS			PTHR44096:SF3	ROUNDABOUT HOMOLOG 3
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-486685|UniProtKB=F6VT32	Protein kinase C	ISS	11880265	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06834	MAP3Ks	MOUSE|MGI=MGI=1346878|UniProtKB=Q07174	Mitogen-activated protein kinase kinase kinase 8	RCA	99133929	PubMed	PTHR24361:SF94	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 8
P00059	p53 pathway	G04702	p53	MOUSE|MGI=MGI=1330810|UniProtKB=O88898	Tumor protein 63	TAS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P06587	Nicotine pharmacodynamics pathway	P06604	SLC18A2	MACMU|Ensembl=ENSMMUG00000014817|UniProtKB=F6VXD8	Uncharacterized protein	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00057	Wnt signaling pathway	P01447	Dishevelled	MONDO|Ensembl=ENSMODG00000006553|UniProtKB=F7BUW7	Uncharacterized protein	ISS	10409711	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P00019	Endothelin signaling pathway	P00568	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IGI	8132661	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	DANRE|ZFIN=ZDB-GENE-030616-162|UniProtKB=F1R3G4	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF328	MYOSIN-10
P02755	Methylmalonyl pathway	P03032	Methylmalonyl-CoA epimerase	CAEEL|WormBase=WBGene00008415|UniProtKB=G5EEG4	Methylmalonyl-CoA Epimerase	ISS			PTHR43048:SF3	METHYLMALONYL-COA EPIMERASE, MITOCHONDRIAL
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	BOVIN|Ensembl=ENSBTAG00000013047|UniProtKB=E1BLE8	Uncharacterized protein	ISS	11431030	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MOUSE|MGI=MGI=96281|UniProtKB=P34968	5-hydroxytryptamine receptor 2C	IDA			PTHR24247:SF32	5-HYDROXYTRYPTAMINE RECEPTOR 2C
P06959	CCKR signaling map	G06973	FOS	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	RCA	9950815	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00018	EGF receptor signaling pathway	P00540	MKK3,6	MACMU|Ensembl=ENSMMUG00000010904|UniProtKB=F7GLY5	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	ANOGA|EnsemblGenome=AGAP006475|UniProtKB=Q5TQX0	AGAP006475-PA	ISS	11007872	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00019	Endothelin signaling pathway	P00591	PLCbeta	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	IGI	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	IDA	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	TAS			PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05731	GABA-B receptor II signaling	P05754	Ggamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00034	Integrin signalling pathway	P00907	ERK	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS			PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00006	Apoptosis signaling pathway	P00307	ELF2alpha	PANTR|Ensembl=ENSPTRG00000006462|UniProtKB=H2Q8H4	Eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa	ISS			PTHR10602:SF0	EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1
P02776	Serine glycine biosynthesis	P03157	Phosphoserine aminotransferase	RAT|RGD=735170|UniProtKB=A0A0G2K931	Phosphoserine aminotransferase	ISS	20886743	gi	PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	ARATH|TAIR=AT2G29900|UniProtKB=Q9SIK7	Presenilin-like protein At2g29900	TAS	12834808	PubMed	PTHR10202:SF22	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00811	Arp2/3 complex	HUMAN|HGNC=703|UniProtKB=Q92747	Actin-related protein 2/3 complex subunit 1A	TAS	12473693	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P02756	N-acetylglucosamine metabolism	P03039	Glucosamine-1-phosphate acetyltransferase	THEMA|EnsemblGenome=TM_1629|UniProtKB=Q9X1W4	Bifunctional protein GlmU	ISS			PTHR43584:SF3	BIFUNCTIONAL PROTEIN GLMU
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	DROME|FlyBase=FBgn0050344|UniProtKB=Q961H2	GH23453p	ISS			PTHR23507:SF1	GH23453P-RELATED
P00049	Parkinson disease	P01230	Src kinase	MACMU|Ensembl=ENSMMUG00000004054|UniProtKB=F6ZR07	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF90	TYROSINE-PROTEIN KINASE YES
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BOVIN|Ensembl=ENSBTAG00000020267|UniProtKB=F1MKX1	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	MOUSE|MGI=MGI=94926|UniProtKB=P51436	D(4) dopamine receptor	ISS	2137198	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	HUMAN|HGNC=11641|UniProtKB=Q9NQB0	Transcription factor 7-like 2	IEP	12356903	PubMed	PTHR10373:SF32	TRANSCRIPTION FACTOR 7-LIKE 2
P00018	EGF receptor signaling pathway	P00547	PP2A	YEAST|SGD=S000005540|UniProtKB=P38903	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	ISS			PTHR10257:SF3	PP2A-B', ISOFORM B
P00006	Apoptosis signaling pathway	P00269	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	RCA	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06754	Ggamma	MOUSE|MGI=MGI=102705|UniProtKB=P63213	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	RCA	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00005	Angiogenesis	P00219	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00010	B cell activation	P00381	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	ISS	96149441	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00034	Integrin signalling pathway	P00906	Rap1	MONDO|Ensembl=ENSMODG00000007323|UniProtKB=F7EFD0	Uncharacterized protein	ISS	1904317	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	MACMU|Ensembl=ENSMMUG00000005147|UniProtKB=O77680	D(1A) dopamine receptor	ISS	9700720	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00019	Endothelin signaling pathway	P00591	PLCbeta	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IGI	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	CANLF|Ensembl=ENSCAFG00000016388|UniProtKB=F6X9W7	Protein-serine/threonine kinase	RCA			PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	DROME|FlyBase=FBgn0010399|UniProtKB=Q24418	Glutamate [NMDA] receptor subunit 1	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	PANTR|Ensembl=ENSPTRG00000009415|UniProtKB=H2QDG2	Nucleoside diphosphate kinase	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	DANRE|Ensembl=ENSDARG00000015050|UniProtKB=Q6PI52	Calmodulin	ISS	9753452	PubMed	PTHR23050:SF326	CALMODULIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=8154|UniProtKB=P41145	Kappa-type opioid receptor	IDA	11259487	PubMed	PTHR24229:SF1	KAPPA-TYPE OPIOID RECEPTOR
P05731	GABA-B receptor II signaling	P05752	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00006	Apoptosis signaling pathway	P00318	PKCs	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	DROME|FlyBase=FBgn0028875|UniProtKB=Q7KT97	Nicotinic acetylcholine receptor alpha5, isoform B	IC	11404397	PubMed	PTHR18945:SF770	NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA5, ISOFORM B
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	RCA	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00010	B cell activation	P00379	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PANTR|Gene=TUBB8|UniProtKB=Q8WP14	Tubulin beta-8 chain	ISS	9454836	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00019	Endothelin signaling pathway	P00570	PKA	YEAST|SGD=S000001295|UniProtKB=P07278	cAMP-dependent protein kinase regulatory subunit	ISS	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00591	PLCbeta	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_114958|UniProtKB=C3XZ13	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF359	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00931	Integrin beta	HUMAN|Ensembl=ENSG00000259753|UniProtKB=H3BM21	Integrin beta (Fragment)	IDA	386150	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	TAS	9332390	PubMed	PTHR10202:SF13	PRESENILIN-2
P00052	TGF-beta signaling pathway	P01275	P38	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	TAS	10995439	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MACMU|Ensembl=ENSMMUG00000017683|UniProtKB=F6UA63	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00005	Angiogenesis	P00227	PLA2	MACMU|Ensembl=ENSMMUG00000021423|UniProtKB=F7EEZ1	Phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	PANTR|Ensembl=ENSPTRG00000021182|UniProtKB=H2QXK2	Receptor protein serine/threonine kinase	ISS	10683140	PubMed	PTHR23255:SF61	TGF-BETA RECEPTOR TYPE-1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	ORNAN|Ensembl=ENSOANG00000002406|UniProtKB=F7BAS2	Uncharacterized protein	ISS	7559398	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	MACMU|Ensembl=ENSMMUG00000009679|UniProtKB=F6YBQ8	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00020	FAS signaling pathway	P00615	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ORYSJ|EnsemblGenome=OS01G0511300|UniProtKB=Q94E72	Os01g0511300 protein	ISS			PTHR10539:SF2	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CANLF|Ensembl=ENSCAFG00000002617|UniProtKB=E2QUL1	Uncharacterized protein	ISS	11319238	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00001	Adrenaline and noradrenaline biosynthesis	P00070	VAT2	BOVIN|Gene=SLC18A2|UniProtKB=Q27963	Synaptic vesicular amine transporter	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	CANLF|Ensembl=ENSCAFG00000002067|UniProtKB=F1PUW7	Uncharacterized protein	ISS	96032356	PubMed	PTHR11958:SF69	EXCITATORY AMINO ACID TRANSPORTER 3
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00056	VEGF signaling pathway	P01417	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00807	Actin	ARATH|TAIR=AT2G42100|UniProtKB=Q8RYC2	Putative actin-5	IDA	11889126	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00012	Cadherin signaling pathway	P00475	Frizzled	XENTR|Xenbase=XB-GENE-480379|UniProtKB=Q6GL20	Frizzled homolog 10	ISS	11212302	PubMed	PTHR11309:SF86	FRIZZLED-10
P02788	Xanthine and guanine salvage pathway	P03245	Guanine phosphoribosyl transferase	TAKRU|Ensembl=ENSTRUG00000003211|UniProtKB=H2S550	Uncharacterized protein	ISS			PTHR43340:SF6	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MOUSE|MGI=MGI=1913963|UniProtKB=P61161	Actin-related protein 2	ISS	10974003	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00019	Endothelin signaling pathway	P00580	ET-RA/B	HUMAN|HGNC=3180|UniProtKB=P24530	Endothelin B receptor	IGI	12875994	PubMed	PTHR24243:SF30	ENDOTHELIN B RECEPTOR
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	MONDO|Ensembl=ENSMODG00000003229|UniProtKB=F6TYA8	Uncharacterized protein (Fragment)	ISS	11212302	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P05915	Opioid proenkephalin pathway	P05994	G-protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	TAS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00053	T cell activation	P01294	NFAT	PANTR|Ensembl=ENSPTRG00000006218|UniProtKB=H2Q834	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00018	EGF receptor signaling pathway	P00561	STAT	MONDO|Ensembl=ENSMODG00000028212|UniProtKB=F7BYN4	Signal transducer and activator of transcription	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P05918	p38 MAPK pathway	P06020	p38delta	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00053	T cell activation	P01305	Calmodulin	CHICK|Gene_ORFName=RCJMB04_24e7|UniProtKB=P62149	Calmodulin	ISS	10487978	PubMed	PTHR23050:SF311	CALMODULIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	ARATH|TAIR=AT5G08080|UniProtKB=Q8VZU2	Syntaxin-132	IC			PTHR19957:SF144	SYNTAXIN-132-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000001583|UniProtKB=F7BBM1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00057	Wnt signaling pathway	P01465	Ggamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IDA	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	PANTR|Ensembl=ENSPTRG00000003983|UniProtKB=H2Q4A0	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IDA	22040490	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00010	B cell activation	P00398	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12880387	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	1170702	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00400	Btk	MOUSE|MGI=MGI=88216|UniProtKB=P35991	Tyrosine-protein kinase BTK	ISS	10521450	PubMed	PTHR24418:SF92	TYROSINE-PROTEIN KINASE BTK
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04393	Ras Pathway	P04569	Cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00029	Huntington disease	P00797	p53	BOVIN|Ensembl=ENSBTAG00000015460|UniProtKB=F1MKA9	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00030	Hypoxia response via HIF activation	P00819	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	IGI	10747026	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04373	5HT1 type receptor mediated signaling pathway	P04409	5HT transporter	PANTR|Ensembl=ENSPTRG00000008958|UniProtKB=H2QCL1	Transporter	ISS	14653308	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00005	Angiogenesis	P00256	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DROME|FlyBase=FBgn0014011|UniProtKB=P48554	Ras-related protein Rac2	ISS	12932731	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	IDA	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00052	TGF-beta signaling pathway	P01284	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04395	Vasopressin synthesis	P04589	Signal Peptidase	RAT|RGD=1563536|UniProtKB=Q568Z4	Signal peptidase complex subunit 3	ISS	2092035	PubMed	PTHR12804:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 3
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	PANTR|Ensembl=ENSPTRG00000004718|UniProtKB=H2Q5I0	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00219	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	RCA	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01202	p85	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	IC	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00038	JAK/STAT signaling pathway	P01027	STAT	BOVIN|Gene=STAT3|UniProtKB=P61635	Signal transducer and activator of transcription 3	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00008	Axon guidance mediated by Slit/Robo	P00352	DCC	MONDO|Ensembl=ENSMODG00000011028|UniProtKB=F7F4D5	Uncharacterized protein	ISS	12810718	PubMed	PTHR44146:SF3	NETRIN RECEPTOR DCC
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00034	Integrin signalling pathway	P00925	MEK	MONDO|Ensembl=ENSMODG00000008266|UniProtKB=F6Z879	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00045	Notch signaling pathway	P01119	NIct	HUMAN|HGNC=7881|UniProtKB=P46531	Neurogenic locus notch homolog protein 1	IGI	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	BOVIN|Ensembl=ENSBTAG00000015988|UniProtKB=F1MYM9	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF335	MYOSIN-11
P00005	Angiogenesis	P00237	FRP	BOVIN|Ensembl=ENSBTAG00000035084|UniProtKB=F1MLG5	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF22	FRIZZLED-3
P00018	EGF receptor signaling pathway	P00562	p38	DANRE|ZFIN=ZDB-GENE-990415-257|UniProtKB=O42376	Mitogen-activated protein kinase 12	ISS	11274345	PubMed	PTHR24055:SF339	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00052	TGF-beta signaling pathway	P01284	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00543	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	21150461	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00057	Wnt signaling pathway	P01457	GBeta	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00005	Angiogenesis	P00189	Fzd	HUMAN|HGNC=4041|UniProtKB=Q9NPG1	Frizzled-3	IDA	8717036	PubMed	PTHR11309:SF22	FRIZZLED-3
P00047	PDGF signaling pathway	P01161	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000010953|UniProtKB=F1Q376	Phosphoinositide phospholipase C	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00058	mRNA splicing	P01474	U5	MACMU|Ensembl=ENSMMUG00000019406|UniProtKB=F6SV59	U5 small nuclear ribonucleoprotein 40 kDa protein	ISS	9774689	PubMed	PTHR44006:SF1	U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN
P05916	Opioid prodynorphin pathway	P06000	vasopressin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MONDO|Ensembl=ENSMODG00000000771|UniProtKB=F6SSS3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00007	Axon guidance mediated by semaphorins	P00331	PAK	MACMU|Ensembl=ENSMMUG00000001387|UniProtKB=F7D0B4	Uncharacterized protein	ISS	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00006	Apoptosis signaling pathway	P00321	HSP70	ENTHI|EnsemblGenome=EHI_052860|UniProtKB=C4M3S5	Heat shock protein 70, putative	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01063	CAT	CHICK|Gene=CHAT|UniProtKB=Q90YJ9	Choline O-acetyltransferase	IC	92155737	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P04393	Ras Pathway	P04572	JNK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00046	Oxidative stress response	P01135	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	TAS	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	IGI	15572354	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00005	Angiogenesis	P00252	Grb2	DANRE|ZFIN=ZDB-GENE-040426-1975|UniProtKB=Q6PC73	Growth factor receptor-bound protein 2	ISS	8479536	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00046	Oxidative stress response	P01131	MKP5	BOVIN|Ensembl=ENSBTAG00000001729|UniProtKB=Q0IID7	Dual specificity protein phosphatase 10	ISS	11856337	PubMed	PTHR10159:SF299	DUAL SPECIFICITY PROTEIN PHOSPHATASE 10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00047	PDGF signaling pathway	P01150	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT4G36450|UniProtKB=O23236	Mitogen-activated protein kinase 14	ISS	10851062	PubMed	PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00810	GAPDH	ARATH|TAIR=AT3G26650|UniProtKB=P25856	Glyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic	IPI			PTHR43148:SF5	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE GAPA1, CHLOROPLASTIC-RELATED
P00010	B cell activation	P00398	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	ARATH|TAIR=AT1G13890|UniProtKB=Q9LMG8	Putative SNAP25 homologous protein SNAP30	ISS			PTHR19305:SF7	SNAP25 HOMOLOGOUS PROTEIN SNAP30-RELATED
P00048	PI3 kinase pathway	P01182	Ras	XENTR|Xenbase=XB-GENE-494548|UniProtKB=F7EC26	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00035	Interferon-gamma signaling pathway	P00956	SOCS	RAT|RGD=1564914|UniProtKB=D3ZUE4	Protein Socs5	ISS	15032587	PubMed	PTHR44282:SF3	SUPPRESSOR OF CYTOKINE SIGNALING 5
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	BOVIN|Ensembl=ENSBTAG00000047202|UniProtKB=G3N3K3	Uncharacterized protein	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00030	Hypoxia response via HIF activation	P00824	PTEN	XENTR|Xenbase=XB-GENE-491433|UniProtKB=B1H2U0	Pten protein	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05925	beta-ARR1	PANTR|Ensembl=ENSPTRG00000004079|UniProtKB=H2R1Z2	Uncharacterized protein	ISS	11742073	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00054	Toll receptor signaling pathway	P01346	TLR	BOVIN|Gene=TLR4|UniProtKB=Q9GL65	Toll-like receptor 4	ISS			PTHR44568:SF1	TOLL-LIKE RECEPTOR 4
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	IDA	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	CANLF|Ensembl=ENSCAFG00000028654|UniProtKB=J9P702	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00059	p53 pathway	P04633	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00586	Gq	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-486685|UniProtKB=F6VT32	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	SCHPO|PomBase=SPAC8C9.03|UniProtKB=P36600	cAMP-dependent protein kinase regulatory subunit	IC	2372396	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P02734	Chorismate biosynthesis	P02869	3-Dehydroquinate dehydratase	STRCO|EnsemblGenome=CAB38151|UniProtKB=P15474	3-dehydroquinate dehydratase	ISS			PTHR21272:SF3	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01289	I-Smads	DROME|FlyBase=FBgn0020493|UniProtKB=Q5U110	Mothers against decapentaplegic homolog	IGI	9335505	PubMed	PTHR13703:SF44	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG
P00047	PDGF signaling pathway	P01159	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00053	T cell activation	P01324	rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	20264070	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00038	JAK/STAT signaling pathway	P01034	Jak	MONDO|Ensembl=ENSMODG00000015373|UniProtKB=F6WH53	Tyrosine-protein kinase	ISS	22482294	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	YEAST|SGD=S000003412|UniProtKB=P49723	Ribonucleoside-diphosphate reductase small chain 2	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00056	VEGF signaling pathway	P01421	Rac	HUMAN|HGNC=9803|UniProtKB=P60763	Ras-related C3 botulinum toxin substrate 3	RCA			PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	TAS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00021	FGF signaling pathway	P00644	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=2683547|UniProtKB=Q4KWH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1	ISS	12860966	PubMed	PTHR10336:SF51	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-1
P00054	Toll receptor signaling pathway	P01369	MKK1	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	BOVIN|Ensembl=ENSBTAG00000006969|UniProtKB=Q2KJD0	Tubulin beta-5 chain	ISS	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04570	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00046	Oxidative stress response	P01131	MKP5	HUMAN|HGNC=17909|UniProtKB=Q9BY84	Dual specificity protein phosphatase 16	ISS			PTHR10159:SF37	DUAL SPECIFICITY PROTEIN PHOSPHATASE 16
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04395	Vasopressin synthesis	P04594	Neurophysin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04393	Ras Pathway	P04559	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	4757952	gi	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00029	Huntington disease	P00790	beta-Tubulin	MACMU|Ensembl=ENSMMUG00000023684|UniProtKB=P69895	Tubulin beta chain	ISS	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00056	VEGF signaling pathway	P01407	Erk	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=107469|UniProtKB=Q8K3R3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	15611108	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=2136741|UniProtKB=Q8CDY9	Protein Pcdhb7	IDA	8120095	PubMed	PTHR24028:SF148	PROTEIN PCDHB7
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	IDA	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00048	PI3 kinase pathway	P01206	14-3-3	MOUSE|MGI=MGI=109484|UniProtKB=P63101	14-3-3 protein zeta/delta	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00021	FGF signaling pathway	P00624	14-3-3	ANOGA|EnsemblGenome=AGAP007643|UniProtKB=A0NBC2	AGAP007643-PA	ISS	10407019	PubMed	PTHR18860:SF13	14-3-3 PROTEIN ZETA
P00046	Oxidative stress response	P01129	JNK1/2	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	TAS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	IC	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=31073|UniProtKB=Q9Y2K3	Myosin-15	IC			PTHR13140:SF575	MYOSIN-15
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	TAKRU|Ensembl=ENSTRUG00000009851|UniProtKB=H2TJ90	Uncharacterized protein	ISS	21455682	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00019	Endothelin signaling pathway	P00591	PLCbeta	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05916	Opioid prodynorphin pathway	P06002	G-protein	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00029	Huntington disease	G01533	Bax	MOUSE|MGI=MGI=99702|UniProtKB=Q07813	Apoptosis regulator BAX	TAS	8358790	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P00012	Cadherin signaling pathway	P00471	Cadherin	BOVIN|Ensembl=ENSBTAG00000011349|UniProtKB=E1BQ10	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF272	CADHERIN-24
P04393	Ras Pathway	P04541	p90RSK	CANLF|Ensembl=ENSCAFG00000013171|UniProtKB=E2RP04	Uncharacterized protein	ISS	10558991	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	CHICK|Gene=CHRM3|UniProtKB=P49578	Muscarinic acetylcholine receptor M3	ISS	12181435	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ORYSJ|EnsemblGenome=OS02G0803700|UniProtKB=P46465	26S protease regulatory subunit 6A homolog	ISS			PTHR23073:SF7	26S PROTEASE REGULATORY SUBUNIT 6A
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	IC	10553940	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ARATH|TAIR=AT3G59790|UniProtKB=Q9M1Z5	Mitogen-activated protein kinase 10	IDA			PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P05913	Enkephalin release	G06045	preproenkephalin	PANTR|Ensembl=ENSPTRG00000020270|UniProtKB=H2QW70	Proenkephalin	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P02748	Isoleucine biosynthesis	P02995	Threonine dehydratase	ECOLI|EcoGene=EG10493|UniProtKB=P04968	L-threonine dehydratase biosynthetic IlvA	ISS			PTHR43714:SF1	THREONINE DEHYDRATASE, MITOCHONDRIAL
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MOUSE|MGI=MGI=1270862|UniProtKB=O88566	Axin-2	IEP	9554852	PubMed	PTHR10845:SF103	AXIN-2
P00046	Oxidative stress response	P01129	JNK1/2	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IGI	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00059	p53 pathway	P01480	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	2837282	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00015	Circadian clock system	P00504	Per	HUMAN|HGNC=8846|UniProtKB=O15055	Period circadian protein homolog 2	IDA	11232563	PubMed	PTHR11269:SF9	PERIOD CIRCADIAN PROTEIN HOMOLOG 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	IC	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00009	Axon guidance mediated by netrin	P00364	cdc42	TAKRU|Ensembl=ENSTRUG00000008289|UniProtKB=H2T7U8	Uncharacterized protein	ISS	12928366	PubMed	PTHR24072:SF129	CDC42L PROTEIN
P00059	p53 pathway	G04694	p110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01284	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00034	Integrin signalling pathway	P00912	Arp2/3	MONDO|Ensembl=ENSMODG00000007194|UniProtKB=F6X9N6	Actin-related protein 2/3 complex subunit 5	ISS	10322212	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	ANOGA|EnsemblGenome=AGAP007120|UniProtKB=Q7QIX6	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00011	Blood coagulation	P00415	Plasmin	HUMAN|HGNC=9071|UniProtKB=P00747	Plasminogen	ISS	130317	gi	PTHR24261:SF6	PLASMINOGEN
P06664	Gonadotropin-releasing hormone receptor pathway	P06807	gnai	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	RCA	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00474	Wnt	ORNAN|Ensembl=ENSOANG00000011077|UniProtKB=F7FK62	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DROME|FlyBase=FBgn0003093|UniProtKB=P13678	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	DANRE|ZFIN=ZDB-GENE-000330-4|UniProtKB=Q1MTI1	Uncharacterized protein	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P05918	p38 MAPK pathway	P06021	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00046	Oxidative stress response	P01134	cPLA2	CANLF|Ensembl=ENSCAFG00000013778|UniProtKB=F6UQ33	Phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	RCA	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00007	Axon guidance mediated by semaphorins	P00340	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BOVIN|Gene=ACTG2|UniProtKB=Q5E9B5	Actin, gamma-enteric smooth muscle	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00019	Endothelin signaling pathway	P00591	PLCbeta	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00022	General transcription by RNA polymerase I	P00649	TAF-IC	XENTR|Xenbase=XB-GENE-491356|UniProtKB=Q28J24	Transcription initiation factor TFIID subunit 8	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00006	Apoptosis signaling pathway	P00321	HSP70	TAKRU|Ensembl=ENSTRUG00000005265|UniProtKB=H2SJP2	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF239	HEAT SHOCK COGNATE 71 KDA PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	CHICK|Ensembl=ENSGALG00000008341|UniProtKB=Q91000	Trans Golgi network protease furin	IDA	10956649	PubMed	PTHR42884:SF1	FURIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Gene=CHRM1|UniProtKB=P56489	Muscarinic acetylcholine receptor M1	IDA			PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	CANLF|Ensembl=ENSCAFG00000028654|UniProtKB=J9P702	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00029	Huntington disease	P00778	NMDA receptor	RAT|RGD=2738|UniProtKB=Q00960	Glutamate receptor ionotropic, NMDA 2B	IDA	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000011842|UniProtKB=G7NAM7	Uncharacterized protein	ISS	11781138	PubMed	PTHR24248:SF26	ALPHA-2B ADRENERGIC RECEPTOR
P00012	Cadherin signaling pathway	P00466	EGFR	HUMAN|HGNC=3236|UniProtKB=P00533	Epidermal growth factor receptor	ISS	20540545	gi	PTHR24416:SF91	EPIDERMAL GROWTH FACTOR RECEPTOR
P00034	Integrin signalling pathway	P00920	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00009	Axon guidance mediated by netrin	P00366	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	20010089	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000013047|UniProtKB=E1BLE8	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00006	Apoptosis signaling pathway	P00318	PKCs	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00025	Hedgehog signaling pathway	P00691	CBP	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	HUMAN|HGNC=8748|UniProtKB=Q16549	Proprotein convertase subtilisin/kexin type 7	IDA			PTHR42884:SF12	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 7
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04586	ProTRH (Pro Thyrotropin-releasing Hormone)	MONDO|Ensembl=ENSMODG00000018321|UniProtKB=Q6YNX4	Glycoprotein hormones alpha chain	ISS			PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P00035	Interferon-gamma signaling pathway	P00960	PTP	RAT|RGD=3447|UniProtKB=P41499	Tyrosine-protein phosphatase non-receptor type 11	TAS	1382983	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P05913	Enkephalin release	P05977	G-Protein (s)	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P02779	Thiamin biosynthesis	P03170	Hydroxymethylpyrimidine phosphate kinase	RHOBA|EnsemblGenome=RB7580|UniProtKB=Q7UNH4	Probable thiamin biosynthesis protein	ISS			PTHR20858:SF17	HYDROXYMETHYLPYRIMIDINE/PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	TAS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00047	PDGF signaling pathway	P01162	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00036	Interleukin signaling pathway	P00965	ERK	MACMU|Ensembl=ENSMMUG00000008503|UniProtKB=F6TGJ6	Uncharacterized protein	ISS	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	DANRE|ZFIN=ZDB-GENE-980605-30|UniProtKB=Q9YHE8	Transcription factor 7-like 1-A	IEP	11266476	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00021	FGF signaling pathway	P00634	MEKK1-5	MOUSE|MGI=MGI=1346876|UniProtKB=O35099	Mitogen-activated protein kinase kinase kinase 5	ISS	12968034	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00057	Wnt signaling pathway	P01451	Galpha	MOUSE|MGI=MGI=95770|UniProtKB=P30678	Guanine nucleotide-binding protein subunit alpha-15	IDA	11534853	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P00025	Hedgehog signaling pathway	P00682	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	IDA	2372396	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00318	PKCs	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00038	JAK/STAT signaling pathway	P01027	STAT	MACMU|Ensembl=ENSMMUG00000010707|UniProtKB=F7G8G5	Signal transducer and activator of transcription	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	BOVIN|Ensembl=ENSBTAG00000000438|UniProtKB=P32236	Gonadotropin-releasing hormone receptor	ISS	1333052	PubMed	PTHR24241:SF22	GONADOTROPIN-RELEASING HORMONE RECEPTOR
P02775	Salvage pyrimidine ribonucleotides	P03150	Uridine kinase	RAT|RGD=620742|UniProtKB=Q9QYG8	Uridine-cytidine kinase 2	ISS			PTHR10285:SF70	URIDINE-CYTIDINE KINASE 2
P00029	Huntington disease	P00807	Actin	PUCGT|EnsemblGenome=PGTG_05488|UniProtKB=E3K4I1	Actin	IDA	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00779	TBP	HALSA|EnsemblGenome=VNG_6438G|UniProtKB=Q9HHE9	TATA-box-binding protein F	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00010	B cell activation	P00385	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12676940	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00030	Hypoxia response via HIF activation	P00823	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01332	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01129	JNK1/2	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00019	Endothelin signaling pathway	P00566	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IGI	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04396	Vitamin D metabolism and pathway	G04688	24-Hydroxylase	MOUSE|MGI=MGI=88593|UniProtKB=Q64441	1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	IDA	11686044	PubMed	PTHR24291:SF5	1,25-DIHYDROXYVITAMIN D 3  24-HYDROXYLASE, MITOCHONDRIAL
P00034	Integrin signalling pathway	P00924	Raf	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS	12068308	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	MACMU|Ensembl=ENSMMUG00000017654|UniProtKB=F6UI32	Beta-arrestin-2 isoform 1	ISS	12464600	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000007882|UniProtKB=G3X7Z2	Uncharacterized protein	ISS	14507926	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00552	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IGI	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00012	Cadherin signaling pathway	P00470	F-actin	RAT|RGD=2025|UniProtKB=P68136	Actin, alpha skeletal muscle	ISS	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00006	Apoptosis signaling pathway	P00310	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	RAT|RGD=621060|UniProtKB=O88777	Presenilin-2	TAS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	NEUCR|EnsemblGenome=EFNCRG00000007441|UniProtKB=Q7SF12	Betaine aldehyde dehydrogenase	IC			PTHR11699:SF25	ALDEHYDE DEHYDROGENASE-LIKE PROTEIN YHR039C-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00012	Cadherin signaling pathway	P00470	F-actin	TRIVA|Gene=TVAG_512800|UniProtKB=A2HNG1	Actin (Fragment)	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02766	Phenylethylamine degradation	P03103	Phenylethylamine oxidase	MOUSE|MGI=MGI=1923757|UniProtKB=Q8JZQ5	Amiloride-sensitive amine oxidase [copper-containing]	ISS			PTHR10638:SF3	AMILORIDE-SENSITIVE AMINE OXIDASE  COPPER-CONTAINING
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	PHANO|EnsemblGenome=SNOG_10086|UniProtKB=Q0UDS8	G-alpha subunit	ISS			PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	DANRE|ZFIN=ZDB-GENE-000328-3|UniProtKB=Q9YI00	Frizzled 8a protein	TAS	11212302	PubMed	PTHR11309:SF90	FRIZZLED-8
P00034	Integrin signalling pathway	P00925	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04393	Ras Pathway	P04570	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01148	Grb2	HUMAN|HGNC=4563|UniProtKB=O75791	GRB2-related adapter protein 2	ISS	51702266	gi	PTHR24418:SF299	GRB2-RELATED ADAPTER PROTEIN 2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IDA	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MOUSE|MGI=MGI=1923959|UniProtKB=Q9CVB6	Actin-related protein 2/3 complex subunit 2	ISS	10940259	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00018	EGF receptor signaling pathway	P00549	EGF	MOUSE|MGI=MGI=98724|UniProtKB=P48030	Protransforming growth factor alpha	IGI	13654266	gi	PTHR10740:SF1	PROTRANSFORMING GROWTH FACTOR ALPHA
P00036	Interleukin signaling pathway	P00987	SRF	RAT|RGD=1559787|UniProtKB=D3ZHH8	Protein Srf	ISS	15326221	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04395	Vasopressin synthesis	P04596	Endo Peptidase	RHOBA|EnsemblGenome=RB12337|UniProtKB=Q7UIT3	Prolyl endopeptidase	IC	9695945	PubMed	PTHR42881:SF2	PROLYL ENDOPEPTIDASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	BOVIN|Ensembl=ENSBTAG00000018204|UniProtKB=Q9BE40	Myosin-1	IC	10938134	PubMed	PTHR13140:SF484	MYOSIN-1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	PANTR|Ensembl=ENSPTRG00000001638|UniProtKB=H2Q0J3	Adenylate cyclase type 10	ISS	11744988	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	MACMU|Ensembl=ENSMMUG00000005688|UniProtKB=F6U5C5	Transcription factor jun-B	ISS	10664585	PubMed	PTHR11462:SF37	TRANSCRIPTION FACTOR JUN-B
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	HUMAN|HGNC=4593|UniProtKB=Q13255	Metabotropic glutamate receptor 1	ISS	8314195	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00049	Parkinson disease	P01211	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	CHICK|Ensembl=ENSGALG00000017238|UniProtKB=F1NWG3	Uncharacterized protein	ISS	7476890	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=107469|UniProtKB=Q8K3R3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	7822322	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00010	B cell activation	P00375	Calmodulin	MACMU|Ensembl=ENSMMUG00000028962|UniProtKB=F7EWG5	Uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF322	SUBFAMILY NOT NAMED
P02771	Pyrimidine Metabolism	P03124	Methylmalonate Semialdehyde Dehydrogenase	MACMU|Ensembl=ENSMMUG00000012684|UniProtKB=F7E2B9	Uncharacterized protein	ISS	1527093	PubMed	PTHR43866:SF3	METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE  ACYLATING , MITOCHONDRIAL
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	TAS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	TAS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00029	Huntington disease	P00780	Microtubule	STRPU|EnsemblGenome=SPU_003894|UniProtKB=W4XKG7	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF155	TUBULIN BETA-2 CHAIN
P00004	Alzheimer disease-presenilin pathway	P00139	E-cadherin transmembrane fragment	XENTR|Xenbase=XB-GENE-482277|UniProtKB=F6QAX3	Uncharacterized protein	ISS	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	MOUSE|MGI=MGI=2442252|UniProtKB=Q8VI56	Low-density lipoprotein receptor-related protein 4	IDA	11907044	PubMed	PTHR44017:SF4	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4
P00059	p53 pathway	P04630	PP2A	DANRE|ZFIN=ZDB-GENE-050417-441|UniProtKB=Q567Y8	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	HUMAN|HGNC=8744|UniProtKB=P16519	Neuroendocrine convertase 2	IDA			PTHR42884:SF13	NEUROENDOCRINE CONVERTASE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00014	Cholesterol biosynthesis	P00493	Geranyl trans-transferase	SCHPO|PomBase=SPBC36.06c|UniProtKB=O59703	Geranylgeranyl pyrophosphate synthase	ISS	O64905	SPACC	PTHR11525:SF0	FARNESYL PYROPHOSPHATE SYNTHASE
P00049	Parkinson disease	P01207	PLD2	HUMAN|HGNC=9068|UniProtKB=O14939	Phospholipase D2	IDA	15030398	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00053	T cell activation	P01297	MEKK	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	RCA	11730323	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	XENTR|Xenbase=XB-GENE-484032|UniProtKB=F6QWD3	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00036	Interleukin signaling pathway	P00996	STAT	HUMAN|HGNC=11368|UniProtKB=P42226	Signal transducer and activator of transcription 6	IGI	8085155	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00036	Interleukin signaling pathway	P00965	ERK	CANLF|Ensembl=ENSCAFG00000015640|UniProtKB=E2QVF3	Uncharacterized protein	ISS	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04651	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	P01443	Phospholipase C	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MOUSE|MGI=MGI=95821|UniProtKB=Q01097	Glutamate receptor ionotropic, NMDA 2B	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00005	Angiogenesis	P00223	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01332	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01135	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	TAS	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05915	Opioid proenkephalin pathway	P05987	peptide F	BOVIN|Ensembl=ENSBTAG00000004924|UniProtKB=P01211	Proenkephalin-A	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P02728	Arginine biosynthesis	P02842	N-acetylornithine aminotransferase	THEMA|EnsemblGenome=TM_1785|UniProtKB=Q9X2A5	Acetylornithine aminotransferase	ISS	10074354	PubMed	PTHR11986:SF79	ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL
P00019	Endothelin signaling pathway	P00589	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MONDO|Ensembl=ENSMODG00000005623|UniProtKB=F7CFG8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00049	Parkinson disease	P01212	p38 MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	PANTR|Ensembl=ENSPTRG00000001638|UniProtKB=H2Q0J3	Adenylate cyclase type 10	ISS	10915626	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00048	PI3 kinase pathway	P01188	Gbetagamma	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00010	B cell activation	P00402	Jnk	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00001	Adrenaline and noradrenaline biosynthesis	P00068	amine translocator	MACMU|Ensembl=ENSMMUG00000010514|UniProtKB=F7B2H0	Transporter	ISS	12719981	PubMed	PTHR11616:SF44	SODIUM- AND CHLORIDE-DEPENDENT TRANSPORTER XTRP3
P00034	Integrin signalling pathway	P00922	Collagen	PANTR|Ensembl=ENSPTRG00000019409|UniProtKB=H2QUY2	Uncharacterized protein	ISS	10778855	PubMed	PTHR24023:SF568	COLLAGEN ALPHA-2 I  CHAIN
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00010	B cell activation	P00393	CD19	HUMAN|HGNC=1633|UniProtKB=P15391	B-lymphocyte antigen CD19	IGI	9653091	PubMed	PTHR16674:SF2	B-LYMPHOCYTE ANTIGEN CD19
P00029	Huntington disease	P00796	Kainate receptor	MACMU|Ensembl=ENSMMUG00000022347|UniProtKB=F6ZCH5	Uncharacterized protein	ISS	1648176	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P05913	Enkephalin release	P05974	G-Protein (i)	ANOGA|EnsemblGenome=AGAP005911|UniProtKB=Q7Q6D4	AGAP005911-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IDA	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00057	Wnt signaling pathway	P01438	PP2A	MACMU|Ensembl=ENSMMUG00000013047|UniProtKB=F7H808	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00314	MKK3	ORNAN|Ensembl=ENSOANG00000007732|UniProtKB=F6PXH5	Uncharacterized protein (Fragment)	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P05918	p38 MAPK pathway	P06031	p38alpha	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	RCA	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01444	Wnt	BOVIN|Ensembl=ENSBTAG00000009217|UniProtKB=F1MEW8	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00053	T cell activation	P01318	PKC-theta	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IGI	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00012	Cadherin signaling pathway	P00465	TCF/LEF	CHICK|Ensembl=ENSGALG00000010529|UniProtKB=O93345	Lymphiod enhancer binding factor 1	ISS	9039917	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	HUMAN|HGNC=6026|UniProtKB=P25024	C-X-C chemokine receptor type 1	ISS	1840701	PubMed	PTHR10489:SF916	C-X-C CHEMOKINE RECEPTOR TYPE 1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00029	Huntington disease	P00805	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	RAT|RGD=628852|UniProtKB=Q02294	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	8386525	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00012	Cadherin signaling pathway	P00470	F-actin	ORYSJ|EnsemblGenome=OS10G0510000|UniProtKB=A3C6D7	Actin-2	IC	10974003	PubMed	PTHR11937:SF252	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	HUMAN|HGNC=7559|UniProtKB=P04198	N-myc proto-oncogene protein	IEP	12356903	PubMed	PTHR11514:SF3	N-MYC PROTO-ONCOGENE PROTEIN
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	CAEBR|Gene=CBG12820|UniProtKB=A8XFP5	Protein CBR-KIN-3	ISS	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05918	p38 MAPK pathway	P05920	MAPKAP-K2	MACMU|Ensembl=ENSMMUG00000023567|UniProtKB=F7HHY8	Uncharacterized protein	ISS	7923354	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00005	Angiogenesis	P00234	Grb2	RAT|RGD=619758|UniProtKB=P62994	Growth factor receptor-bound protein 2	RCA			PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00029	Huntington disease	P00803	Sp1	PANTR|Ensembl=ENSPTRG00000005014|UniProtKB=H2Q623	Sp1 transcription factor	RCA			PTHR23235:SF16	TRANSCRIPTION FACTOR SP1
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00015	Circadian clock system	P00504	Per	RAT|RGD=621581|UniProtKB=Q8CJE2	Period circadian protein homolog 3	ISS			PTHR11269:SF13	PERIOD CIRCADIAN PROTEIN HOMOLOG 3
P00049	Parkinson disease	P01234	GRK	BOVIN|Gene=ADRBK1|UniProtKB=P21146	Beta-adrenergic receptor kinase 1	IDA	8288567	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P04393	Ras Pathway	P04569	Cdc42	TAKRU|Ensembl=ENSTRUG00000008289|UniProtKB=H2T7U8	Uncharacterized protein	ISS	12928366	PubMed	PTHR24072:SF129	CDC42L PROTEIN
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000017387|UniProtKB=E2RLD1	Uncharacterized protein	ISS	12507995	PubMed	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=262|UniProtKB=P30542	Adenosine receptor A1	ISS	12515326	PubMed	PTHR24246:SF1	ADENOSINE RECEPTOR A1
P00010	B cell activation	P00369	MEKK	MOUSE|MGI=MGI=1346874|UniProtKB=Q61084	Mitogen-activated protein kinase kinase kinase 3	IDA	8649450	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P06959	CCKR signaling map	P07090	MAPK8-10	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	RCA	20150185	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04393	Ras Pathway	P04542	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00012	Cadherin signaling pathway	P00470	F-actin	DANRE|ZFIN=ZDB-GENE-040426-2894|UniProtKB=Q7SXW6	Actin-related protein 2-A	ISS	11889126	PubMed	PTHR11937:SF149	ACTIN-RELATED PROTEIN 2-A-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	HUMAN|HGNC=1392|UniProtKB=Q15878	Voltage-dependent R-type calcium channel subunit alpha-1E	IDA	14507926	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00057	Wnt signaling pathway	P01439	C-terminal Binding Protein	MONDO|Ensembl=ENSMODG00000010255|UniProtKB=F6W5N2	Uncharacterized protein	ISS	10375506	PubMed	PTHR10996:SF72	C-TERMINAL-BINDING PROTEIN 2
P00050	Plasminogen activating cascade	P01249	pro-tPA	PANTR|Ensembl=ENSPTRG00000020201|UniProtKB=H2QW33	Tissue-type plasminogen activator	ISS	4505861	gi	PTHR44617:SF1	TISSUE-TYPE PLASMINOGEN ACTIVATOR
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00057	Wnt signaling pathway	P01454	betaTrCP	BOVIN|Ensembl=ENSBTAG00000015376|UniProtKB=F1MLG0	Uncharacterized protein	ISS	10074433	PubMed	PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CHICK|Ensembl=ENSGALG00000017238|UniProtKB=F1NWG3	Uncharacterized protein	IDA	12351712	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	CHICK|Ensembl=ENSGALG00000007794|UniProtKB=A9YZQ5	Dopamine receptor 2 protein transcript variant 1	ISS	11248120	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00003	Alzheimer disease-amyloid secretase pathway	P00087	Fe65	PANTR|Ensembl=ENSPTRG00000003288|UniProtKB=H2Q320	Uncharacterized protein	ISS	11441186	PubMed	PTHR14058:SF5	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P02740	De novo pyrimidine ribonucleotides biosythesis	P02927	Dihydrooratate oxidase	DROME|FlyBase=FBgn0000447|UniProtKB=P32748	Dihydroorotate dehydrogenase (quinone), mitochondrial	ISS			PTHR43517:SF1	DIHYDROOROTATE DEHYDROGENASE  QUINONE , MITOCHONDRIAL
P00053	T cell activation	P01337	B7	MOUSE|MGI=MGI=101775|UniProtKB=Q00609	T-lymphocyte activation antigen CD80	IDA	1650475	PubMed	PTHR25466:SF4	T-LYMPHOCYTE ACTIVATION ANTIGEN CD80
P00047	PDGF signaling pathway	P01174	Rho	MOUSE|MGI=MGI=1925764|UniProtKB=Q6Y5D8	Rho GTPase-activating protein 10	ISS	8649427	PubMed	PTHR12552:SF5	RHO GTPASE-ACTIVATING PROTEIN 10
P00036	Interleukin signaling pathway	P00990	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IC	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	RCA			PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00059	p53 pathway	G01571	FAS	BOVIN|Ensembl=ENSBTAG00000010785|UniProtKB=P51867	Tumor necrosis factor receptor superfamily member 6	ISS	14585074	PubMed	PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P00012	Cadherin signaling pathway	P00475	Frizzled	HUMAN|HGNC=4041|UniProtKB=Q9NPG1	Frizzled-3	IDA	12549854	PubMed	PTHR11309:SF22	FRIZZLED-3
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00052	TGF-beta signaling pathway	P01292	RSmads	CAEEL|WormBase=WBGene00004858|UniProtKB=P45897	Dwarfin sma-4	ISS			PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P04395	Vasopressin synthesis	P04593	Glycopeptide	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P05734	Synaptic vesicle trafficking	P05773	Munc13	PANTR|Ensembl=ENSPTRG00000009659|UniProtKB=H2QDW4	Uncharacterized protein	ISS	608897	OMIM	PTHR10774:SF98	PROTEIN UNC-13 HOMOLOG D
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	21071228	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	CANLF|Ensembl=ENSCAFG00000028654|UniProtKB=J9P702	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00562	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	PANTR|Ensembl=ENSPTRG00000018684|UniProtKB=C7G3M7	Glutamate receptor, metabotropic 1	ISS	12488551	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00053	T cell activation	P01304	Csk	HUMAN|HGNC=2444|UniProtKB=P41240	Tyrosine-protein kinase CSK	IDA	7687537	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2743|UniProtKB=P31421	Metabotropic glutamate receptor 2	IDA	12351712	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DICDI|dictyBase=DDB_G0277143|UniProtKB=P36408	Guanine nucleotide-binding protein subunit beta	IC	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00012	Cadherin signaling pathway	P00462	Casein kinase II	MOUSE|MGI=MGI=88547|UniProtKB=O54833	Casein kinase II subunit alpha'	ISS	10806215	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P05912	Dopamine receptor mediated signaling pathway	P05963	MAO	PANTR|Ensembl=ENSPTRG00000021816|UniProtKB=H2QYH5	Amine oxidase [flavin-containing]	ISS	90344230	PubMed	PTHR43563:SF3	AMINE OXIDASE  FLAVIN-CONTAINING  A
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	RAT|RGD=2740|UniProtKB=Q62645	Glutamate receptor ionotropic, NMDA 2D	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2D.html	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	ORNAN|Ensembl=ENSOANG00000002061|UniProtKB=F7ANC6	Uncharacterized protein	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00047	PDGF signaling pathway	P01150	PKC	CANAL|CGD=CAL0003231|UniProtKB=Q5ANK2	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00048	PI3 kinase pathway	P01177	P110ACT	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00220	c-Jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P02725	Allantoin degradation	P02821	Allantoate amidohydrolase	RAT|RGD=621804|UniProtKB=Q6AYP0	Probable allantoicase	ISS			PTHR12045:SF3	ALLANTOICASE-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	ARATH|TAIR=AT4G34460|UniProtKB=P49177	Guanine nucleotide-binding protein subunit beta	ISS			PTHR19850:SF48	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02738	De novo purine biosynthesis	P02894	IMP cyclohydrolase	MYCTU|EnsemblGenome=Rv0957|UniProtKB=P9WHM7	Bifunctional purine biosynthesis protein PurH	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00865	Shc	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	ISS	7680960	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=2558|UniProtKB=P50279	Syntaxin-2	IC			PTHR19957:SF36	SYNTAXIN-2
P00006	Apoptosis signaling pathway	P00269	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00059	p53 pathway	G04702	p53	RAT|RGD=1307083|UniProtKB=D4AA88	Protein Tp73	ISS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00024	Glycolysis	P00679	Aldolase	MACMU|Ensembl=ENSMMUG00000000983|UniProtKB=F6SYL4	Fructose-bisphosphate aldolase	ISS	74094688	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	MOUSE|MGI=MGI=106217|UniProtKB=Q61290	Voltage-dependent R-type calcium channel subunit alpha-1E	IDA	8386525	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P05916	Opioid prodynorphin pathway	P06000	vasopressin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00019	Endothelin signaling pathway	P00587	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CANLF|Ensembl=ENSCAFG00000019823|UniProtKB=E2R4I7	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	IDA	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00029	Huntington disease	P00779	TBP	SCHPO|PomBase=SPAC29E6.08|UniProtKB=P17871	TATA-box-binding protein	IPI	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00006	Apoptosis signaling pathway	P00282	IGFR2	HUMAN|HGNC=5467|UniProtKB=P11717	Cation-independent mannose-6-phosphate receptor	IDA	6382022	PubMed	PTHR15071:SF17	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MOUSE|MGI=MGI=1098271|UniProtKB=O08849	Regulator of G-protein signaling 2	ISS	8756726	PubMed	PTHR10845:SF43	REGULATOR OF G-PROTEIN SIGNALING 2
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	BACSU|EnsemblGenome=BSU00090|UniProtKB=P21879	Inosine-5'-monophosphate dehydrogenase	ISS			PTHR11911:SF6	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE
P00049	Parkinson disease	P01211	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	P04635	Sumo-1 ligase	MACMU|Ensembl=ENSMMUG00000021194|UniProtKB=F7GXX7	Small ubiquitin-related modifier	ISS			PTHR10562:SF52	SMALL UBIQUITIN-RELATED MODIFIER 1
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	YEAST|SGD=S000004219|UniProtKB=P19073	Cell division control protein 42	ISS	4757952	gi	PTHR24072:SF192	CDC42 HOMOLOG
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	PANTR|Ensembl=ENSPTRG00000014309|UniProtKB=H2QLK6	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF317	MYOSIN-9
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	PANTR|Ensembl=ENSPTRG00000002979|UniProtKB=H2Q2M8	Uncharacterized protein	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00001	Adrenaline and noradrenaline biosynthesis	P00068	amine translocator	RAT|RGD=1594328|UniProtKB=Q2A865	Sodium-dependent neutral amino acid transporter B(0)AT1	ISS	12719981	PubMed	PTHR11616:SF125	SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER B 0 AT1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00552	Ras	DICDI|dictyBase=DDB_G0281385|UniProtKB=P32253	Ras-like protein rasC	IGI	94119591	PubMed	PTHR24070:SF251	RAS-LIKE PROTEIN RASC
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	MACMU|Ensembl=ENSMMUG00000016428|UniProtKB=F7GU00	Metabotropic glutamate receptor 1 isoform alpha	ISS	8314195	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00047	PDGF signaling pathway	P01142	p90RSK	BOVIN|Ensembl=ENSBTAG00000014447|UniProtKB=A4IFF4	Ribosomal protein S6 kinase	ISS	2779569	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05731	GABA-B receptor II signaling	P05760	AC	MACMU|Ensembl=ENSMMUG00000006253|UniProtKB=F7H582	Uncharacterized protein	ISS	10978539	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	7925653	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00940	Src	CHICK|Ensembl=ENSGALG00000003855|UniProtKB=P00523	Proto-oncogene tyrosine-protein kinase Src	IPI	8054685	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00021	FGF signaling pathway	P00627	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	21186066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P02741	Flavin biosynthesis	P02935	GTP cyclohydrolase	STRCO|Gene=CAC17559|UniProtKB=Q9EWJ8	Riboflavin biosynthesis protein RibBA	ISS			PTHR21327:SF32	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01202	p85	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	IGI	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00046	Oxidative stress response	P01134	cPLA2	MACMU|Ensembl=ENSMMUG00000021423|UniProtKB=F7EEZ1	Phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	IC	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00637	MKK4,7	BOVIN|Ensembl=ENSBTAG00000012103|UniProtKB=A5PJP8	MAP2K4 protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00012	Cadherin signaling pathway	P00470	F-actin	STRPU|Gene=CYIIIB|UniProtKB=P18499	Actin, cytoskeletal 3B	IC	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	HUMAN|HGNC=10896|UniProtKB=P12755	Ski oncogene	IGI	10485843	PubMed	PTHR10005:SF15	SKI ONCOGENE
P00021	FGF signaling pathway	P00636	FGFR1-4	PANTR|Ensembl=ENSPTRG00000020176|UniProtKB=H2R210	Fibroblast growth factor receptor	ISS	1708247	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	HUMAN|HGNC=1389|UniProtKB=Q00975	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	14624853	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00034	Integrin signalling pathway	P00944	Actin	RAT|RGD=628837|UniProtKB=P60711	Actin, cytoplasmic 1	IPI	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	RCA			PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01408	Akt/PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Gene=GRIK4|UniProtKB=Q5IS46	Glutamate receptor ionotropic, kainate 4	ISS	12941441	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00056	VEGF signaling pathway	P01425	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	15572354	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P06664	Gonadotropin-releasing hormone receptor pathway	G06886	CGA	MOUSE|MGI=MGI=88390|UniProtKB=P01216	Glycoprotein hormones alpha chain	RCA	1099091	PubMed	PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P04393	Ras Pathway	P04569	Cdc42	HUMAN|HGNC=1736|UniProtKB=P60953	Cell division control protein 42 homolog	IDA	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00021	FGF signaling pathway	P00646	RasGAP	DROME|FlyBase=FBgn0003969|UniProtKB=Q8IR23	GH13542p	ISS	17737349	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04453	ACTH	MOUSE|MGI=MGI=97742|UniProtKB=P01193	Pro-opiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00018	EGF receptor signaling pathway	P00557	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IGI	10799299	PubMed	PTHR10048:SF14	PI-3 KINASE
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	DANRE|ZFIN=ZDB-GENE-000403-2|UniProtKB=P57095	Axin-2	IEP	12356903	PubMed	PTHR10845:SF103	AXIN-2
P04397	p53 pathway by glucose deprivation	P04641	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00019	Endothelin signaling pathway	P00566	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01168	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DROME|FlyBase=FBgn0000489|UniProtKB=P16912	Protein kinase DC2	IC	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00059	p53 pathway	P04623	CBP	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00059	p53 pathway	G04694	p110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P02770	Pyridoxal phosphate salvage pathway	P03121	Pyridoxal kinase	DROME|FlyBase=FBgn0085484|UniProtKB=Q7KUC2	FI04467p	ISS			PTHR10534:SF2	PYRIDOXAL KINASE
P00006	Apoptosis signaling pathway	P00284	Flip	PANTR|Ensembl=ENSPTRG00000012798|UniProtKB=H2R695	CASP8 and FADD-like apoptosis regulator	ISS	9217161	PubMed	PTHR10454:SF8	CASP8 AND FADD-LIKE APOPTOSIS REGULATOR
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=1935205|UniProtKB=Q91XW9	MCG133388, isoform CRA_f	IDA	8120095	PubMed	PTHR24028:SF234	PROTOCADHERIN GAMMA-C5
P00006	Apoptosis signaling pathway	P00297	NFkappaB	BOVIN|Ensembl=ENSBTAG00000038428|UniProtKB=G3N1S2	Uncharacterized protein	ISS			PTHR24169:SF18	TRANSCRIPTION FACTOR RELB
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	MACMU|Ensembl=ENSMMUG00000017022|UniProtKB=F7HQZ9	Uncharacterized protein	ISS	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00010	B cell activation	P00391	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00546	GAP	RAT|RGD=3168|UniProtKB=P97526	Neurofibromin	ISS	90304909	PubMed	PTHR10194:SF60	NEUROFIBROMIN
P00053	T cell activation	P01300	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	ISS	14698601	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=2652894|UniProtKB=Q80Y86	Mitogen-activated protein kinase 15	ISS	9891064	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	IDA	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00632	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00274	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00021	FGF signaling pathway	P00624	14-3-3	DANRE|ZFIN=ZDB-GENE-050306-44|UniProtKB=Q5CZQ1	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P02738	De novo purine biosynthesis	P02905	Amidophosphoribosyl transferase	DEIRA|EnsemblGenome=DR_0220|UniProtKB=Q9RXT6	Amidophosphoribosyltransferase	ISS			PTHR11907:SF0	AMIDOPHOSPHORIBOSYLTRANSFERASE
P00047	PDGF signaling pathway	P01143	ERK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CAEBR|Gene=CBG18256|UniProtKB=A8XS95	Protein CBR-ACT-5	ISS	11889126	PubMed	PTHR11937:SF352	ACTIN
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01447	Dishevelled	MACMU|Ensembl=ENSMMUG00000010542|UniProtKB=F7D0L2	Segment polarity protein dishevelled homolog DVL-2	ISS	10409711	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CHICK|Ensembl=ENSGALG00000007509|UniProtKB=F1NM72	Uncharacterized protein	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CAEBR|Gene=CBG02162|UniProtKB=A8WS33	Protein CBG02162	ISS	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	MACMU|Ensembl=ENSMMUG00000017022|UniProtKB=F7HQZ9	Uncharacterized protein	ISS	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT1G10210|UniProtKB=Q39021	Mitogen-activated protein kinase 1	ISS	15218451	gi	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P04395	Vasopressin synthesis	P04597	Signal Peptide	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04397	p53 pathway by glucose deprivation	P04641	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04398	p53 pathway feedback loops 2	P04666	cyclin A	RAT|RGD=621059|UniProtKB=G3V802	Cyclin A2, isoform CRA_b	ISS			PTHR10177:SF69	CYCLIN-A2
P00047	PDGF signaling pathway	P01163	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	HUMAN|HGNC=8528|UniProtKB=P01178	Oxytocin-neurophysin 1	ISS	1706187	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00054	Toll receptor signaling pathway	P01346	TLR	MOUSE|MGI=MGI=1932389|UniProtKB=Q9EQU3	Toll-like receptor 9	ISS			PTHR24373:SF37	TOLL-LIKE RECEPTOR 9
P00034	Integrin signalling pathway	P00907	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00384	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	ISS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00009	Axon guidance mediated by netrin	P00366	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00034	Integrin signalling pathway	P00944	Actin	CRYNJ|EnsemblGenome=CNA04650|UniProtKB=Q5KP06	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00054	Toll receptor signaling pathway	P01352	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6879|UniProtKB=Q16659	Mitogen-activated protein kinase 6	ISS	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	SCHPO|PomBase=SPAC110.03|UniProtKB=Q01112	Cell division control protein 42 homolog	ISS			PTHR24072:SF192	CDC42 HOMOLOG
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02774	Salvage pyrimidine deoxyribonucleotides	P03148	Thymidine phosphorylase	ECOLI|EcoGene=EG10219|UniProtKB=P07650	Thymidine phosphorylase	ISS	11677608	PubMed	PTHR10515:SF0	THYMIDINE PHOSPHORYLASE
P04398	p53 pathway feedback loops 2	P04651	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	RAT|RGD=2848|UniProtKB=P08909	5-hydroxytryptamine receptor 2C	ISS	11859080	PubMed	PTHR24247:SF32	5-HYDROXYTRYPTAMINE RECEPTOR 2C
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P02729	Ascorbate degradation	P02852	L-xylulose-5-phosphate-3-epimerase	SCHPO|PomBase=SPAC31G5.05c|UniProtKB=O14105	Ribulose-phosphate 3-epimerase	ISS			PTHR11749:SF3	RIBULOSE-PHOSPHATE 3-EPIMERASE
P00052	TGF-beta signaling pathway	P01284	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014262|UniProtKB=F7BYS8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IGI	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00401	jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MONDO|Ensembl=ENSMODG00000013079|UniProtKB=F7FB74	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ANOGA|EnsemblGenome=AGAP006521|UniProtKB=Q7Q5C3	AGAP006521-PA	IC	2106672	PubMed	PTHR10218:SF229	GUANINE NUCLEOTIDE-BINDING PROTEIN G F  SUBUNIT ALPHA
P02755	Methylmalonyl pathway	P03034	Methylmalonyl-CoA mutase	CAEEL|WormBase=WBGene00014202|UniProtKB=Q23381	Probable methylmalonyl-CoA mutase, mitochondrial	ISS			PTHR42710:SF1	METHYLMALONYL-COA MUTASE, MITOCHONDRIAL
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	PANTR|Ensembl=ENSPTRG00000010931|UniProtKB=H2R650	Uncharacterized protein	ISS	8930069	PubMed	PTHR13715:SF15	RYANODINE RECEPTOR 1
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MOUSE|MGI=MGI=87947|UniProtKB=P28650	Adenylosuccinate synthetase isozyme 1	IEP	10636885	PubMed	PTHR11846:SF2	ADENYLOSUCCINATE SYNTHETASE ISOZYME 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04395	Vasopressin synthesis	P04596	Endo Peptidase	RAT|RGD=1310143|UniProtKB=Q5HZA6	Prolyl endopeptidase-like	ISS	9695945	PubMed	PTHR11757:SF12	PROLYL ENDOPEPTIDASE-LIKE
P00048	PI3 kinase pathway	P01188	Gbetagamma	ARATH|TAIR=AT4G34460|UniProtKB=P49177	Guanine nucleotide-binding protein subunit beta	IC	9754712	PubMed	PTHR19850:SF48	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA
P00021	FGF signaling pathway	P00632	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04398	p53 pathway feedback loops 2	P04665	AKT	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	ISS	95181376	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04393	Ras Pathway	P04543	MEKK1/4	PANTR|Ensembl=ENSPTRG00000016891|UniProtKB=H2R5K3	Uncharacterized protein	ISS	12049732	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00054	Toll receptor signaling pathway	P01366	MKK4	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00038	JAK/STAT signaling pathway	P01034	Jak	BOVIN|Ensembl=ENSBTAG00000003147|UniProtKB=F1N0D6	Tyrosine-protein kinase	ISS	9637709	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MONDO|Ensembl=ENSMODG00000018204|UniProtKB=F6PGX6	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	HUMAN|HGNC=3084|UniProtKB=O14640	Segment polarity protein dishevelled homolog DVL-1	TAS	7906389	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000017346|UniProtKB=Q5DRB3	Protocadherin gamma-A7	ISS	8120095	PubMed	PTHR24028:SF56	PROTOCADHERIN GAMMA-A7
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	IC	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00053	T cell activation	P01332	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00056	VEGF signaling pathway	P01417	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	3449797	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00623	FGF	HUMAN|HGNC=3665|UniProtKB=P05230	Fibroblast growth factor 1	IGI	12799194	PubMed	PTHR11486:SF86	FIBROBLAST GROWTH FACTOR 1
P00024	Glycolysis	P00679	Aldolase	MOUSE|MGI=MGI=87994|UniProtKB=P05064	Fructose-bisphosphate aldolase A	ISS	3391172	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P02776	Serine glycine biosynthesis	P03160	Phosphoglycerate dehydrogenase	SCHPO|PomBase=SPCC364.07|UniProtKB=P87228	Putative D-3-phosphoglycerate dehydrogenase	ISS			PTHR10996:SF165	D-3-PHOSPHOGLYCERATE DEHYDROGENASE 1-RELATED
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04559	Rac	ENTHI|EnsemblGenome=EHI_070730|UniProtKB=C4M5T0	Rho family GTPase	ISS	97082968	PubMed	PTHR24072:SF117	RHO-RELATED PROTEIN RACC
P00059	p53 pathway	G01579	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	LEIMA|EnsemblGenome=LmjF.12.0280|UniProtKB=Q4QGR5	Putative ornithine decarboxylase	ISS			PTHR11482:SF6	ORNITHINE DECARBOXYLASE 1-RELATED
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=16265|UniProtKB=Q9H1J7	Protein Wnt-5b	IDA	8717036	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00018	EGF receptor signaling pathway	P00547	PP2A	HUMAN|HGNC=9299|UniProtKB=P67775	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	IGI	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01320	PLC-gamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00046	Oxidative stress response	P01125	Stat1	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P04398	p53 pathway feedback loops 2	P04649	Myc	BOVIN|Ensembl=ENSBTAG00000008409|UniProtKB=Q2HJ27	Myc proto-oncogene protein	ISS	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00019	Endothelin signaling pathway	P00589	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	ISS	14684598	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00010	B cell activation	P00373	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	RAT|RGD=2917|UniProtKB=P15127	Insulin receptor	ISS	14500580	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P02770	Pyridoxal phosphate salvage pathway	P03122	Pyridoxamine kinase	HUMAN|HGNC=8819|UniProtKB=O00764	Pyridoxal kinase	ISS	9099727	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P00054	Toll receptor signaling pathway	P01355	AP1	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00005	Angiogenesis	P00246	Ang-2	MACMU|Ensembl=ENSMMUG00000010139|UniProtKB=F6QXG9	Uncharacterized protein	ISS	9204896	PubMed	PTHR19143:SF199	ANGIOPOIETIN-2
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00022	General transcription by RNA polymerase I	P00656	PTRF	CANLF|Ensembl=ENSCAFG00000028879|UniProtKB=J9P923	Uncharacterized protein	ISS	603198	OMIM	PTHR15240:SF3	POLYMERASE I AND TRANSCRIPT RELEASE FACTOR
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00220	c-Jun	CHICK|Gene=JUN|UniProtKB=P18870	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	ISS	10188796	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00060	Ubiquitin proteasome pathway	P01494	19S proteasome	ORYSJ|EnsemblGenome=OS02G0325100|UniProtKB=Q6Z875	Os02g0325100 protein	ISS			PTHR23073:SF8	26S PROTEASE REGULATORY SUBUNIT 6B
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00371	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00025	Hedgehog signaling pathway	P00682	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	RAT|RGD=620023|UniProtKB=P10980	Muscarinic acetylcholine receptor M2	TAS	8100450	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00967	c-fos	CANLF|Ensembl=ENSCAFG00000017040|UniProtKB=E2QYK5	Uncharacterized protein	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00021	FGF signaling pathway	P00627	ERK1-2	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01407	Erk	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	RAT|RGD=1304556|UniProtKB=P63259	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00034	Integrin signalling pathway	P00911	B-Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	ISS	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P04398	p53 pathway feedback loops 2	G04714	PTEN	TAKRU|Ensembl=ENSTRUG00000009851|UniProtKB=H2TJ90	Uncharacterized protein	IGI	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00021	FGF signaling pathway	P00646	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	IPI	227170	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	BOVIN|Ensembl=ENSBTAG00000011723|UniProtKB=E1BKL6	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04393	Ras Pathway	P04546	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	IDA	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04452	proopiomelanocortin	MONDO|Ensembl=ENSMODG00000015853|UniProtKB=Q95J84	Proopiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	ISS	9851932	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01038	Vglut	MOUSE|MGI=MGI=1920211|UniProtKB=Q3TXX4	Vesicular glutamate transporter 1	ISS	15192755	PubMed	PTHR11662:SF138	VESICULAR GLUTAMATE TRANSPORTER 1
P05916	Opioid prodynorphin pathway	P06001	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	TAKRU|Ensembl=ENSTRUG00000009283|UniProtKB=Q6SJ94	TATA box-binding protein-like protein 2	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	DROME|FlyBase=FBgn0264492|UniProtKB=P08181	Casein kinase II subunit alpha	ISS	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	MACMU|Ensembl=ENSMMUG00000020819|UniProtKB=F7HSM1	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	DANRE|ZFIN=ZDB-GENE-030616-162|UniProtKB=F1R3G4	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF328	MYOSIN-10
P00049	Parkinson disease	P01238	14-3-3	MONDO|Ensembl=ENSMODG00000013658|UniProtKB=F6TY10	Uncharacterized protein	ISS	91108808	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00015	Circadian clock system	G01501	cry	PANTR|Ensembl=ENSPTRG00000005396|UniProtKB=H2Q6S7	Cryptochrome 1 (Photolyase-like)	ISS	10217146	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00010	B cell activation	P00391	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ORYSJ|EnsemblGenome=OS06G0699400|UniProtKB=Q5Z859	Mitogen-activated protein kinase 4	ISS	10851062	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	BOVIN|Ensembl=ENSBTAG00000017679|UniProtKB=F1MY55	Uncharacterized protein	ISS			PTHR24361:SF183	SERINE/THREONINE-PROTEIN KINASE PAK 7
P00018	EGF receptor signaling pathway	P00560	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06747	ActRII	MOUSE|MGI=MGI=102806|UniProtKB=P27038	Activin receptor type-2A	RCA	9395284	PubMed	PTHR23255:SF64	ACTIVIN RECEPTOR TYPE-2A
P00045	Notch signaling pathway	P01105	TACE	BOVIN|Ensembl=ENSBTAG00000001141|UniProtKB=G3MZB3	Uncharacterized protein	ISS	12834808	PubMed	PTHR11905:SF171	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	TAKRU|Ensembl=ENSTRUG00000016241|UniProtKB=H2UX35	Protein kinase C	ISS	11880265	PubMed	PTHR24356:SF305	PROTEIN KINASE C
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05731	GABA-B receptor II signaling	P05755	Gbeta	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P05913	Enkephalin release	P05977	G-Protein (s)	CRYNJ|EnsemblGenome=CND03830|UniProtKB=Q5KI86	Uncharacterized protein	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00547	PP2A	MONDO|Ensembl=ENSMODG00000019001|UniProtKB=F7CP86	Serine/threonine-protein phosphatase	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05913	Enkephalin release	P05977	G-Protein (s)	DANRE|ZFIN=ZDB-GENE-050417-59|UniProtKB=Q15KE4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00036	Interleukin signaling pathway	P00965	ERK	BOVIN|Ensembl=ENSBTAG00000005865|UniProtKB=G5E577	Uncharacterized protein	ISS	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P02752	Mannose metabolism	P03019	P-Mannose mutase	DROME|FlyBase=FBgn0036300|UniProtKB=Q9VTZ6	Probable phosphomannomutase	IEA	10731132	PubMed	PTHR10466:SF7	PHOSPHOMANNOMUTASE-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00922	Collagen	MOUSE|MGI=MGI=88452|UniProtKB=P28481	Collagen alpha-1(II) chain	IDA	10778855	PubMed	PTHR24023:SF58	COLLAGEN ALPHA-1 II  CHAIN
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	IC	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01451	Galpha	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00006	Apoptosis signaling pathway	P00302	ATF	CANLF|Ensembl=ENSCAFG00000013332|UniProtKB=F1PCQ4	Uncharacterized protein	ISS	10207617	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00012	Cadherin signaling pathway	P00474	Wnt	BOVIN|Ensembl=ENSBTAG00000001668|UniProtKB=F1N6L8	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00052	TGF-beta signaling pathway	P01284	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	DROME|FlyBase=FBgn0010051|UniProtKB=P29993	Inositol 1,4,5-trisphosphate receptor	ISS	11007872	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00038	JAK/STAT signaling pathway	P01034	Jak	MACMU|Ensembl=ENSMMUG00000014558|UniProtKB=F7GT47	Tyrosine-protein kinase	ISS	22482294	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	TAS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	BOVIN|Ensembl=ENSBTAG00000008026|UniProtKB=P01175	Oxytocin-neurophysin 1	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MONDO|Ensembl=ENSMODG00000004411|UniProtKB=F6SV50	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF58	ACTIVIN RECEPTOR TYPE-1C
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	PANTR|Gene=CXCR1|UniProtKB=P55920	C-X-C chemokine receptor type 1	ISS	6753456	gi	PTHR10489:SF916	C-X-C CHEMOKINE RECEPTOR TYPE 1
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	RAT|RGD=2521|UniProtKB=P19020	D(3) dopamine receptor	RCA	2137198	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04397	p53 pathway by glucose deprivation	P04641	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00038	JAK/STAT signaling pathway	P01027	STAT	CANLF|Ensembl=ENSCAFG00000015346|UniProtKB=E2RE22	Signal transducer and activator of transcription	ISS	95236292	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	ANOGA|Gene=AgaP_AGAP009115|UniProtKB=Q7PW25	Phosphoinositide phospholipase C (Fragment)	TAS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00034	Integrin signalling pathway	P00910	Grb2	MACMU|Ensembl=ENSMMUG00000005327|UniProtKB=F7GJG7	GRB2-related adapter protein	ISS	51702266	gi	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P06664	Gonadotropin-releasing hormone receptor pathway	P06841	gnaq/11	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	RCA	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00057	Wnt signaling pathway	P01438	PP2A	TAKRU|Ensembl=ENSTRUG00000011169|UniProtKB=H2TU36	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	IGI	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	TAKRU|Ensembl=ENSTRUG00000014690|UniProtKB=H2UKR9	Uncharacterized protein	IDA	2039532	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05913	Enkephalin release	P05971	CREB	HUMAN|HGNC=2345|UniProtKB=P16220	Cyclic AMP-responsive element-binding protein 1	ISS	11752053	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P06959	CCKR signaling map	P07228	MAPK1/3	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	RCA		PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00056	VEGF signaling pathway	P01408	Akt/PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000006307|UniProtKB=H2SSM1	Uncharacterized protein	IC			PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00029	Huntington disease	P00810	GAPDH	CHLTR|EnsemblGenome=CT_505|UniProtKB=P0CE13	Glyceraldehyde-3-phosphate dehydrogenase	IPI			PTHR10836:SF76	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE A
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	TAS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=1309999|UniProtKB=Q922R0	cAMP-dependent protein kinase catalytic subunit PRKX	IC	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00053	T cell activation	P01307	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00048	PI3 kinase pathway	P01182	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=1549775|UniProtKB=G3V987	Protein Pcdhb17	ISS	8120095	PubMed	PTHR24028:SF71	PROTOCADHERIN BETA-16
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	IDA	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00010	B cell activation	P00370	NFkappaB	MOUSE|MGI=MGI=1099800|UniProtKB=Q9WTK5	Nuclear factor NF-kappa-B p100 subunit	IDA	20151924	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00019	Endothelin signaling pathway	P00589	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	NAS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01275	P38	CAEBR|Gene=CBG01555|UniProtKB=A8WRD7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00049	Parkinson disease	P01242	Casein kinase I	LEIMA|EnsemblGenome=LmjF.35.1000|UniProtKB=Q9NHE2	Casein kinase 1 isoform 1	IDA	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00049	Parkinson disease	P01242	Casein kinase I	DANRE|ZFIN=ZDB-GENE-030131-825|UniProtKB=Q7T2E3	Casein kinase I isoform delta-A	ISS	10617630	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00037	Ionotropic glutamate receptor pathway	P01023	CaMKII	BOVIN|Ensembl=ENSBTAG00000012653|UniProtKB=Q3MHJ9	Calcium/calmodulin-dependent protein kinase type II subunit beta	ISS	12888804	PubMed	PTHR43940:SF3	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT BETA
P00053	T cell activation	P01298	NFkappaB	MOUSE|MGI=MGI=97312|UniProtKB=P25799	Nuclear factor NF-kappa-B p105 subunit	IGI	12574369	PubMed	PTHR24169:SF9	NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MOUSE|MGI=MGI=1351342|UniProtKB=Q3UVX5	Metabotropic glutamate receptor 5	ISS	7476890	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P05918	p38 MAPK pathway	P06041	Cdc42	MACMU|Ensembl=ENSMMUG00000022009|UniProtKB=F6RBZ7	Cell division control protein 42 homolog isoform 2	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MONDO|Ensembl=ENSMODG00000001389|UniProtKB=F7BD45	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF657	MYOSIN-4
P04393	Ras Pathway	P04570	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	IDA	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P01483	Mdm2	RAT|RGD=1305332|UniProtKB=A0A0G2JVC1	Protein Mdm2	ISS	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TRIAD|EnsemblGenome=TriadG49626|UniProtKB=B3RKR4	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IDA	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-7595|UniProtKB=Q6PBR4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00006	Apoptosis signaling pathway	P00269	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	RAT|RGD=1560083|UniProtKB=D3ZZK7	Protein Myo3a	ISS	22028976	PubMed	PTHR13140:SF387	MYOSIN-IIIA
P00057	Wnt signaling pathway	P01465	Ggamma	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00049	Parkinson disease	P01230	Src kinase	MACMU|Ensembl=ENSMMUG00000017017|UniProtKB=F7FVL2	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IC	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00053	T cell activation	P01312	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IDA	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00878	INFgamma	MACMU|Ensembl=ENSMMUG00000019225|UniProtKB=P63310	Interferon gamma	TAS	11929133	PubMed	PTHR11419:SF0	INTERFERON GAMMA
P00034	Integrin signalling pathway	P00944	Actin	BOVIN|Gene=ACTB|UniProtKB=P60712	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	RAT|RGD=2641|UniProtKB=Q62844	Tyrosine-protein kinase Fyn	ISS	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ORNAN|Ensembl=ENSOANG00000007405|UniProtKB=F7CIV4	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04552	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IDA	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00006	Apoptosis signaling pathway	P00318	PKCs	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00036	Interleukin signaling pathway	P00973	PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01230	Src kinase	MACMU|Ensembl=ENSMMUG00000014434|UniProtKB=F7BHF8	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF224	TYROSINE-PROTEIN KINASE FGR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	BOVIN|Ensembl=ENSBTAG00000015802|UniProtKB=F1MQ10	Uncharacterized protein	RCA			PTHR22952:SF96	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 2
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01199	Galpha	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	IC	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00005	Angiogenesis	P00181	SHP2	CHICK|Ensembl=ENSGALG00000004821|UniProtKB=Q90687	Tyrosine-protein phosphatase non-receptor type 11	ISS	95163101	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00008	Axon guidance mediated by Slit/Robo	P00344	Netrin	HUMAN|HGNC=8029|UniProtKB=O95631	Netrin-1	ISS	11356879	PubMed	PTHR10574:SF365	NETRIN-1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00030	Hypoxia response via HIF activation	P00819	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02735	Cobalamin biosynthesis	P02881	Ribazole-5-phosphate phosphatase	NEUCR|EnsemblGenome=EFNCRG00000009306|UniProtKB=Q7SBZ4	Phosphoglycerate mutase	ISS			PTHR23029:SF55	FRUCTOSE-2,6-BISPHOSPHATASE TIGAR
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00038	JAK/STAT signaling pathway	P01034	Jak	MOUSE|MGI=MGI=96629|UniProtKB=Q62120	Tyrosine-protein kinase JAK2	ISS	22482294	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00036	Interleukin signaling pathway	P00965	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04558	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IDA	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT1G18150|UniProtKB=Q9LM33	Mitogen-activated protein kinase 8	ISS	176948	OMIM	PTHR24055:SF246	MITOGEN-ACTIVATED PROTEIN KINASE 15-RELATED
P00057	Wnt signaling pathway	P01454	betaTrCP	RAT|RGD=1359721|UniProtKB=F1LMH8	Protein Btrc	ISS	10074433	PubMed	PTHR44038:SF2	F-BOX/WD REPEAT-CONTAINING PROTEIN 1A
P00029	Huntington disease	P00807	Actin	XENTR|Xenbase=XB-GENE-490883|UniProtKB=Q6NVA9	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00552	Ras	PANTR|Ensembl=ENSPTRG00000011307|UniProtKB=H2QGV8	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF245	RAS-RELATED PROTEIN R-RAS
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04546	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IDA	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00029	Huntington disease	P00810	GAPDH	TAKRU|Ensembl=ENSTRUG00000017358|UniProtKB=H2V5I4	Glyceraldehyde-3-phosphate dehydrogenase	ISS			PTHR10836:SF79	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE, TESTIS-SPECIFIC
P00006	Apoptosis signaling pathway	P00318	PKCs	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MOUSE|MGI=MGI=88180|UniProtKB=P21275	Bone morphogenetic protein 4	TAS	9759503	PubMed	PTHR11848:SF165	BONE MORPHOGENETIC PROTEIN 4
P04393	Ras Pathway	P04546	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF31	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEEL|WormBase=WBGene00004033|UniProtKB=P90980	Protein kinase C-like 2	ISS	3755548	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00047	PDGF signaling pathway	P01143	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_125401|UniProtKB=C3ZTX6	Putative uncharacterized protein	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02734	Chorismate biosynthesis	P02874	Shikimate kinase	GLOVI|EnsemblGenome=BAC90651|UniProtKB=Q7NH27	Shikimate kinase	ISS			PTHR21087:SF0	SHIKIMATE KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05915	Opioid proenkephalin pathway	P05994	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00047	PDGF signaling pathway	P01150	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05913	Enkephalin release	P05977	G-Protein (s)	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	TAKRU|Ensembl=ENSTRUG00000008018|UniProtKB=H2T5N4	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00005	Angiogenesis	P00207	Crk	XENTR|Xenbase=XB-GENE-996357|UniProtKB=F6XER9	Uncharacterized protein	ISS	8649368	PubMed	PTHR19969:SF8	ADAPTER MOLECULE CRK
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	HUMAN|HGNC=1389|UniProtKB=Q00975	Voltage-dependent N-type calcium channel subunit alpha-1B	IDA	11976940	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P04393	Ras Pathway	P04556	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IDA	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01092	delta	CHICK|Gene=CHRND|UniProtKB=P02717	Acetylcholine receptor subunit delta	ISS	85203892	PubMed	PTHR18945:SF61	ACETYLCHOLINE RECEPTOR SUBUNIT DELTA
P00021	FGF signaling pathway	P00629	PP2A	BOVIN|Ensembl=ENSBTAG00000000469|UniProtKB=P67774	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P02738	De novo purine biosynthesis	P02891	GDP kinase	CHICK|Ensembl=ENSGALG00000002932|UniProtKB=O57535	Nucleoside diphosphate kinase	ISS			PTHR11349:SF57	NUCLEOSIDE DIPHOSPHATE KINASE B
P00053	T cell activation	P01320	PLC-gamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IC	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00811	Arp2/3 complex	CHICK|Ensembl=ENSGALG00000004693|UniProtKB=Q5ZJI7	Uncharacterized protein	ISS	12932731	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00564	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12932731	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00004	Alzheimer disease-presenilin pathway	P00111	C99	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00012	Cadherin signaling pathway	P00474	Wnt	ANOGA|EnsemblGenome=AGAP009734|UniProtKB=Q5TP56	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	BOVIN|Ensembl=ENSBTAG00000006495|UniProtKB=P11017	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P02779	Thiamin biosynthesis	P03170	Hydroxymethylpyrimidine phosphate kinase	SCHPO|PomBase=SPBP8B7.17c|UniProtKB=O94265	Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 1	ISS			PTHR20858:SF17	HYDROXYMETHYLPYRIMIDINE/PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED
P00009	Axon guidance mediated by netrin	P00363	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	BRAFL|Gene=BRAFLDRAFT_124235|UniProtKB=C3Y3Q1	Putative uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF89	TUBULIN BETA-4 CHAIN
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	ARATH|TAIR=AT3G61160|UniProtKB=O23145	Shaggy-related protein kinase beta	TAS			PTHR24057:SF19	SHAGGY-RELATED PROTEIN KINASE BETA-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=1336171|UniProtKB=Q9DAS9	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00019	Endothelin signaling pathway	P00589	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9060|UniProtKB=P51178	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	12860966	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P04392	P53 pathway feedback loops 1	G04682	MDM-2	PANTR|Ensembl=ENSPTRG00000001889|UniProtKB=H2R875	Mdm4 p53 binding protein homolog	ISS			PTHR13844:SF20	PROTEIN MDM4
P00059	p53 pathway	P04630	PP2A	TRIAD|EnsemblGenome=TriadG63380|UniProtKB=B3S653	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	DANRE|ZFIN=ZDB-GENE-020125-5|UniProtKB=A2CG69	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF356	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00023	General transcription regulation	P00666	TFIIE	MACMU|Ensembl=ENSMMUG00000000459|UniProtKB=F6YR60	Transcription initiation factor IIE subunit beta	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P00006	Apoptosis signaling pathway	P00260	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IGI	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06786	ERK1/2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	RCA	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P02727	Androgen/estrogene/progesterone biosynthesis	P02830	Cholesterol esterase	RAT|RGD=3008|UniProtKB=Q64194	Lysosomal acid lipase/cholesteryl ester hydrolase	TAS	2069957	PubMed	PTHR11005:SF26	LYSOSOMAL ACID LIPASE/CHOLESTERYL ESTER HYDROLASE
P00030	Hypoxia response via HIF activation	P00819	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02774	Salvage pyrimidine deoxyribonucleotides	P03145	Uracil phosphorylase	METAC|EnsemblGenome=MA_3242|UniProtKB=Q8TL01	AMP phosphorylase	ISS	12125824	PubMed	PTHR10515:SF0	THYMIDINE PHOSPHORYLASE
P00018	EGF receptor signaling pathway	P00558	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00012	Cadherin signaling pathway	P00467	alpha-catenin	HUMAN|HGNC=2511|UniProtKB=Q9UI47	Catenin alpha-3	ISS	9362521	PubMed	PTHR18914:SF21	CATENIN ALPHA-3
P00034	Integrin signalling pathway	P00925	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00049	Parkinson disease	P01211	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00036	Interleukin signaling pathway	P00964	p90RSK	HUMAN|HGNC=10430|UniProtKB=Q15418	Ribosomal protein S6 kinase alpha-1	ISS	12769834	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04393	Ras Pathway	P04561	SRF	HUMAN|HGNC=11291|UniProtKB=P11831	Serum response factor	IDA	8660892	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00057	Wnt signaling pathway	P01465	Ggamma	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00057	Wnt signaling pathway	P01428	Frizzled	RAT|RGD=71012|UniProtKB=Q08464	Frizzled-2	IDA	11212302	PubMed	PTHR11309:SF34	FRIZZLED-2
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00916	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	IC	10218114	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MACMU|Ensembl=ENSMMUG00000001353|UniProtKB=F7D6T8	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	TAS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	DROME|FlyBase=FBgn0038491|UniProtKB=Q9VEM0	CG5292, isoform A	ISS			PTHR11079:SF92	TRNA-SPECIFIC ADENOSINE DEAMINASE 2
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00054	Toll receptor signaling pathway	P01368	MKK2	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8659|UniProtKB=O60245	Protocadherin-7	IDA	8120095	PubMed	PTHR43912:SF8	PROTOCADHERIN-7
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05913	Enkephalin release	P05974	G-Protein (i)	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	ORNAN|Ensembl=ENSOANG00000002061|UniProtKB=F7ANC6	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P06959	CCKR signaling map	P07111	TRAF6	HUMAN|HGNC=12036|UniProtKB=Q9Y4K3	TNF receptor-associated factor 6	RCA	10094049	PubMed	PTHR10131:SF111	TNF RECEPTOR-ASSOCIATED FACTOR 6
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	RCA	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	G01529	Proline oxidase	RAT|RGD=1590932|UniProtKB=F1MAR6	Uncharacterized protein	ISS			PTHR13914:SF0	PROLINE DEHYDROGENASE 1, MITOCHONDRIAL
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	PANTR|Ensembl=ENSPTRG00000000255|UniProtKB=H2PY66	Uncharacterized protein	ISS			PTHR14516:SF3	DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE, MITOCHONDRIAL
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	MACMU|Ensembl=ENSMMUG00000002794|UniProtKB=F7H232	Transcription initiation factor IIB	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MOUSE|MGI=MGI=1339967|UniProtKB=B1AR69	Protein Myh13	IEP	10938134	PubMed	PTHR13140:SF504	MYOSIN-13
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00005	Angiogenesis	P00208	MEKK1	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	ISS	8643568	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	XENTR|Xenbase=XB-GENE-494200|UniProtKB=F7CS79	Uncharacterized protein	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P02747	Histidine biosynthesis	P02984	Imidazol glycerol phosphate dehydratase	METAC|EnsemblGenome=MA_0219|UniProtKB=P58878	Imidazoleglycerol-phosphate dehydratase	ISS			PTHR23133:SF2	IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00054	Toll receptor signaling pathway	P01367	MKK3	MONDO|Ensembl=ENSMODG00000001404|UniProtKB=F7BD74	Uncharacterized protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00005	Angiogenesis	P00186	FGFR-1	BOVIN|Ensembl=ENSBTAG00000015457|UniProtKB=A4IFL5	Fibroblast growth factor receptor	ISS	9989949	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P00057	Wnt signaling pathway	P01430	p53	MACMU|Ensembl=ENSMMUG00000008639|UniProtKB=P56424	Cellular tumor antigen p53	IDA	11313951	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00034	Integrin signalling pathway	P00907	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00056	VEGF signaling pathway	P01413	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00475	Frizzled	ORNAN|Ensembl=ENSOANG00000008874|UniProtKB=F7F2K2	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF23	FRIZZLED-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	IC	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00060	Ubiquitin proteasome pathway	P01491	E2	CAEEL|WormBase=WBGene00006715|UniProtKB=Q9TZ69	UBiquitin Conjugating enzyme	ISS			PTHR44020:SF2	UBIQUITIN-CONJUGATING ENZYME E2 K
P04395	Vasopressin synthesis	P04597	Signal Peptide	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00049	Parkinson disease	P01230	Src kinase	RAT|RGD=621017|UniProtKB=Q07014	Tyrosine-protein kinase Lyn	IDA	1371009	PubMed	PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000018361|UniProtKB=P60020	5-hydroxytryptamine receptor 1B	ISS	11454663	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P00046	Oxidative stress response	P01137	MNK1/2	BOVIN|Gene=MKNK1|UniProtKB=Q58D94	MAP kinase-interacting serine/threonine-protein kinase 1	ISS	9155018	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00011	Blood coagulation	P00429	PN2	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	ISS	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00008	Axon guidance mediated by Slit/Robo	P00347	Abl	PANTR|Ensembl=ENSPTRG00000021477|UniProtKB=H2QY21	Tyrosine-protein kinase	ISS			PTHR24418:SF88	TYROSINE-PROTEIN KINASE ABL1
P00021	FGF signaling pathway	P00643	Raf-1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IGI	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	MACMU|Ensembl=ENSMMUG00000014498|UniProtKB=F7GEI8	Uncharacterized protein	ISS	14507926	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	PANTR|Ensembl=ENSPTRG00000018449|UniProtKB=H2QTG5	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00014	Cholesterol biosynthesis	P00496	Diphosphomevalonate decarboxylase	DROME|FlyBase=FBgn0030683|UniProtKB=Q9VXQ3	CG8239, isoform A	ISS	4505289	gi	PTHR10977:SF3	DIPHOSPHOMEVALONATE DECARBOXYLASE
P00003	Alzheimer disease-amyloid secretase pathway	P00079	alpha7 nicotinic acetylcholine receptor	RAT|RGD=2348|UniProtKB=Q05941	Neuronal acetylcholine receptor subunit alpha-7	IDA	85270494	PubMed	PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P00018	EGF receptor signaling pathway	P00552	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00012	Cadherin signaling pathway	P00470	F-actin	CANLF|Ensembl=ENSCAFG00000015708|UniProtKB=F2Z4N0	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00037	Ionotropic glutamate receptor pathway	P01020	NSF	PANTR|Ensembl=ENSPTRG00000009320|UniProtKB=H2QD95	N-ethylmaleimide-sensitive factor	ISS	7969419	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347742|UniProtKB=E9FZ00	Cytoplasmatic actin	ISS	10974003	PubMed	PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MACMU|Ensembl=ENSMMUG00000016675|UniProtKB=F6VTB5	Uncharacterized protein	ISS	11554554	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	MACMU|Ensembl=ENSMMUG00000003842|UniProtKB=F7HAF3	Phospholipase A2	ISS	1709551	gi	PTHR10728:SF32	CYTOSOLIC PHOSPHOLIPASE A2 BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	ISS	8457205	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P02777	Succinate to proprionate conversion	P03163	Methylmalonyl-CoA decarboxylase	RAT|RGD=1359654|UniProtKB=Q6AYG5	Ethylmalonyl-CoA decarboxylase	RCA			PTHR11941:SF27	ETHYLMALONYL-COA DECARBOXYLASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PANTR|Ensembl=ENSPTRG00000009762|UniProtKB=H2QE24	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CIOIN|Ensembl=ENSCING00000007153|UniProtKB=L7N0T1	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00203	Erk	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04398	p53 pathway feedback loops 2	P04658	PTEN	TAKRU|Ensembl=ENSTRUG00000009851|UniProtKB=H2TJ90	Uncharacterized protein	IGI	21455682	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00018	EGF receptor signaling pathway	P00562	p38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IGI	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00018	EGF receptor signaling pathway	P00551	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IGI	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	RAT|RGD=2027|UniProtKB=P63269	Actin, gamma-enteric smooth muscle	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00018	EGF receptor signaling pathway	P00558	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00019	Endothelin signaling pathway	P00590	IP3 R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00017	DNA replication	P00535	5' to 3' Exoribonulcease	BOVIN|Ensembl=ENSBTAG00000011304|UniProtKB=F1MKX7	Uncharacterized protein	ISS	7885830	PubMed	PTHR12341:SF41	5'-3' EXORIBONUCLEASE 2
P00048	PI3 kinase pathway	P01192	p110	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	MONDO|Ensembl=ENSMODG00000007421|UniProtKB=F6XBV3	Uncharacterized protein	ISS	15226293	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00055	Transcription regulation by bZIP transcription factor	P01395	TFIIE	ANOGA|EnsemblGenome=AGAP006355|UniProtKB=Q5TR07	AGAP006355-PA	ISS			PTHR13097:SF7	NOVEL PROTEIN SIMILAR TO VERTEBRATE GENERAL TRANSCRIPTION FACTOR IIE POLYPEPTIDE 1 ALPHA 56KDA  GTF2E1
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	DANRE|ZFIN=ZDB-GENE-020125-3|UniProtKB=E7F1V8	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	RCA	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01192	p110	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IC	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00029	Huntington disease	P00811	Arp2/3 complex	MOUSE|MGI=MGI=3648102|UniProtKB=E9Q2K4	Actin-related protein 2/3 complex subunit 5	TAS	12932731	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04395	Vasopressin synthesis	P04589	Signal Peptidase	HUMAN|HGNC=28962|UniProtKB=Q15005	Signal peptidase complex subunit 2	ISS	7788527	PubMed	PTHR13085:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	89186920	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	CANLF|Ensembl=ENSCAFG00000008977|UniProtKB=J9P7Q4	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF4	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4
P00019	Endothelin signaling pathway	P00572	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	MOUSE|MGI=MGI=96575|UniProtKB=P15208	Insulin receptor	ISS	2983222	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04393	Ras Pathway	P04570	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	RAT|RGD=2746|UniProtKB=P31424	Metabotropic glutamate receptor 5	IDA	92317054	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00036	Interleukin signaling pathway	P00996	STAT	HUMAN|HGNC=11366|UniProtKB=P42229	Signal transducer and activator of transcription 5A	IC	8732682	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P05915	Opioid proenkephalin pathway	P05987	peptide F	RAT|RGD=68946|UniProtKB=P04094	Proenkephalin-A	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P05730	Endogenous cannabinoid signaling	P05751	Galpha	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00543	ERK1-2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01440	Cadherin	CAEEL|WormBase=WBGene00000396|UniProtKB=Q19319	Cadherin-4	IDA	8120095	PubMed	PTHR43956:SF7	CADHERIN-4
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	ISS	http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	ANOGA|EnsemblGenome=AGAP002578|UniProtKB=F5HKU8	AGAP002578-PB	ISS	14624853	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05916	Opioid prodynorphin pathway	P05999	provasopressin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00005	Angiogenesis	P00223	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	HUMAN|HGNC=143|UniProtKB=P68032	Actin, alpha cardiac muscle 1	IEP	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	BOVIN|Ensembl=ENSBTAG00000018204|UniProtKB=Q9BE40	Myosin-1	ISS	10938134	PubMed	PTHR13140:SF484	MYOSIN-1
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	TAS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	MOUSE|MGI=MGI=101931|UniProtKB=P43006	Excitatory amino acid transporter 2	IC	94365697	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P00034	Integrin signalling pathway	P00907	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	20384797	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04371	5-Hydroxytryptamine biosynthesis	P04400	Aromatic L-amino acid decarboxylase	DROME|FlyBase=FBgn0000422|UniProtKB=P05031	Aromatic-L-amino-acid decarboxylase	ISS	7567987	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	RAT|RGD=2345|UniProtKB=P04757	Neuronal acetylcholine receptor subunit alpha-3	ISS	12098588	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00018	EGF receptor signaling pathway	P00545	JNK1-3	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IGI	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00034	Integrin signalling pathway	P00945	Parvin	MOUSE|MGI=MGI=1931144|UniProtKB=Q9EPC1	Alpha-parvin	IPI	11331308	PubMed	PTHR12114:SF6	ALPHA-PARVIN
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	TAS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00807	Actin	DANRE|ZFIN=ZDB-GENE-000329-1|UniProtKB=Q7ZVI7	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00012	Cadherin signaling pathway	P00465	TCF/LEF	MONDO|Ensembl=ENSMODG00000015573|UniProtKB=F7AIP6	Uncharacterized protein (Fragment)	ISS	12356903	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00018	EGF receptor signaling pathway	P00562	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	ISS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P02787	Vitamin B6 metabolism	P03236	Pyridoxamine phosphate oxidase	CANLF|Ensembl=ENSCAFG00000016814|UniProtKB=E2QTE2	Uncharacterized protein	ISS	14697241	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00010	B cell activation	P00379	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00034	Integrin signalling pathway	P00912	Arp2/3	RAT|RGD=1311985|UniProtKB=B2GV73	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	IDA	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00805	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02734	Chorismate biosynthesis	P02870	3-Phosphoshikimate-1-carboxyvinyl transferase	DEIRA|EnsemblGenome=DR_1096|UniProtKB=Q9RVD3	3-phosphoshikimate 1-carboxyvinyltransferase	ISS			PTHR21090:SF5	PENTAFUNCTIONAL AROM POLYPEPTIDE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00896	Insulin IGF	DANRE|ZFIN=ZDB-GENE-010607-2|UniProtKB=Q90VV9	Insulin-like growth factor 1	ISS			PTHR11454:SF4	INSULIN-LIKE GROWTH FACTOR I
P00034	Integrin signalling pathway	P00936	PI3K	DROME|FlyBase=FBgn0015278|UniProtKB=Q7K3H0	LD28067p	IPI	96278830	PubMed	PTHR10048:SF64	LD28067P
P00005	Angiogenesis	P00186	FGFR-1	PANTR|Ensembl=ENSPTRG00000020176|UniProtKB=H2R210	Fibroblast growth factor receptor	ISS	12799194	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	MOUSE|MGI=MGI=1351339|UniProtKB=Q14BI2	Metabotropic glutamate receptor 2	ISS	12351712	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00048	PI3 kinase pathway	P01198	FOXO	RAT|RGD=620283|UniProtKB=G3V7R4	Forkhead box protein O1	ISS	10347145	PubMed	PTHR11829:SF159	FORKHEAD BOX PROTEIN O1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MONDO|Ensembl=ENSMODG00000023942|UniProtKB=F7F878	Uncharacterized protein	ISS	12562507	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P00049	Parkinson disease	P01212	p38 MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=88355|UniProtKB=P15116	Cadherin-2	IDA	8120095	PubMed	PTHR24027:SF79	CADHERIN-2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00047	PDGF signaling pathway	P01153	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00047	PDGF signaling pathway	P01162	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00059	p53 pathway	G04694	p110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1354946|UniProtKB=Q61532	Mitogen-activated protein kinase 6	IDA	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	MACMU|Ensembl=ENSMMUG00000017921|UniProtKB=F7EDG8	Uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF335	CALMODULIN, STRIATED MUSCLE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000012036|UniProtKB=F7ALP1	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02772	Pyruvate metabolism	P03140	Pyruvate Carboxylase	PANTR|Ensembl=ENSPTRG00000023133|UniProtKB=H2R399	Pyruvate carboxylase	ISS	12112657	PubMed	PTHR43778:SF2	PYRUVATE CARBOXYLASE, MITOCHONDRIAL
P00012	Cadherin signaling pathway	P00477	GSK3beta	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00047	PDGF signaling pathway	P01167	Ets	RAT|RGD=1310603|UniProtKB=D3ZEY9	Protein Etv2	ISS	15298723	PubMed	PTHR11849:SF206	ETS TRANSLOCATION VARIANT 2
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CANLF|Gene=GRIN1|UniProtKB=Q5R1P0	Glutamate receptor ionotropic, NMDA 1	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	RAT|RGD=620781|UniProtKB=A0A0G2JVK0	Protein Cited1	TAS	9865691	PubMed	PTHR17045:SF6	CBP/P300-INTERACTING TRANSACTIVATOR 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00047	PDGF signaling pathway	P01153	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MOUSE|MGI=MGI=108407|UniProtKB=P97428	Regulator of G-protein signaling 16	ISS	8756726	PubMed	PTHR10845:SF187	REGULATOR OF G-PROTEIN SIGNALING 16
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	HUMAN|HGNC=6843|UniProtKB=P46734	Dual specificity mitogen-activated protein kinase kinase 3	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P06587	Nicotine pharmacodynamics pathway	P06596	Grb2	XENTR|Xenbase=XB-GENE-6070000|UniProtKB=Q66II3	Growth factor receptor-bound protein 2	ISS	11384839	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	TAS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=268|UniProtKB=P0DMS8	Adenosine receptor A3	IDA	12515326	PubMed	PTHR24246:SF2	ADENOSINE RECEPTOR A3
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00053	T cell activation	P01294	NFAT	CANLF|Ensembl=ENSCAFG00000011625|UniProtKB=F1PDD9	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00019	Endothelin signaling pathway	P00572	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	SYNY3|EnsemblGenome=BAA16887|UniProtKB=P72871	S-adenosylmethionine synthase	ISS			PTHR11964:SF1	S-ADENOSYLMETHIONINE SYNTHASE
P00057	Wnt signaling pathway	P01434	sFRP	MONDO|Ensembl=ENSMODG00000010484|UniProtKB=F7ESJ0	Uncharacterized protein	ISS	9096311	PubMed	PTHR11309:SF87	SECRETED FRIZZLED-RELATED PROTEIN 1
P00057	Wnt signaling pathway	P01465	Ggamma	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	NEUCR|EnsemblGenome=EFNCRG00000006213|UniProtKB=Q05425	Guanine nucleotide-binding protein alpha-1 subunit	ISS			PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=11433|UniProtKB=Q16623	Syntaxin-1A	ISS	1321498	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	MOUSE|MGI=MGI=894644|UniProtKB=Q8CC27	Voltage-dependent L-type calcium channel subunit beta-2	IC	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00034	Integrin signalling pathway	P00913	Csk	MONDO|Ensembl=ENSMODG00000009310|UniProtKB=F7GJZ7	Tyrosine-protein kinase	ISS	7687537	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IDA	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	MACMU|Ensembl=ENSMMUG00000005147|UniProtKB=O77680	D(1A) dopamine receptor	ISS	11861492	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	ARATH|TAIR=AT3G59790|UniProtKB=Q9M1Z5	Mitogen-activated protein kinase 10	TAS			PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PHYIT|EnsemblGenome=PITG_15078|UniProtKB=D0NRL5	Actin-like protein	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00054	Toll receptor signaling pathway	P01367	MKK3	CHICK|Ensembl=ENSGALG00000004735|UniProtKB=F1NHE1	Uncharacterized protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	XENTR|Xenbase=XB-GENE-854877|UniProtKB=F7C949	Presenilin	ISS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=1930705|UniProtKB=P61264	Syntaxin-1B	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	CHICK|Ensembl=ENSGALG00000006205|UniProtKB=F1NXP2	Uncharacterized protein	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P00052	TGF-beta signaling pathway	P01285	TAK	XENTR|Xenbase=XB-GENE-481530|UniProtKB=F6U298	Uncharacterized protein	RCA			PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00202	Sck	HUMAN|HGNC=29869|UniProtKB=P98077	SHC-transforming protein 2	IDA	600560	OMIM	PTHR10337:SF5	SHC-TRANSFORMING PROTEIN 2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04398	p53 pathway feedback loops 2	P04658	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PHYPA|Gene=PHYPADRAFT_109052|UniProtKB=A9TZ58	Actin 5	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00059	p53 pathway	P01486	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	ARATH|TAIR=AT5G07880|UniProtKB=Q9SD96	SNAP25 homologous protein SNAP29	IC			PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00054	Toll receptor signaling pathway	P01358	ERK1	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00009	Axon guidance mediated by netrin	P00366	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	10891487	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P05913	Enkephalin release	P05977	G-Protein (s)	MACMU|Ensembl=ENSMMUG00000010266|UniProtKB=F6PV18	Uncharacterized protein	ISS	14500986	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P05912	Dopamine receptor mediated signaling pathway	P05957	K+ channel	HUMAN|HGNC=6278|UniProtKB=O14649	Potassium channel subfamily K member 3	ISS	15282272	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	HUMAN|HGNC=14088|UniProtKB=Q9UGC6	Regulator of G-protein signaling 17	IDA	8756726	PubMed	PTHR10845:SF196	REGULATOR OF G-PROTEIN SIGNALING 17
P00051	TCA cycle	P01266	Pyruvate Dehydrogenase	STRCO|Gene=CAB99150|UniProtKB=Q9K3H0	Putative pyruvate dehydrogenase alpha subunit	ISS	12000953	PubMed	PTHR11516:SF2	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	PANTR|Ensembl=ENSPTRG00000009415|UniProtKB=H2QDG2	Nucleoside diphosphate kinase	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	PANTR|Ensembl=ENSPTRG00000015131|UniProtKB=H2QMZ1	Uncharacterized protein	ISS			PTHR22778:SF26	DIHYDROFOLATE REDUCTASE, MITOCHONDRIAL
P00010	B cell activation	P00379	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00034	Integrin signalling pathway	P00920	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00029	Huntington disease	P00777	CBP	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	IDA	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	RAT|RGD=61862|UniProtKB=P19491	Glutamate receptor 2	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00036	Interleukin signaling pathway	P00981	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	BOVIN|Ensembl=ENSBTAG00000007996|UniProtKB=E1BE22	Uncharacterized protein	ISS	12181435	PubMed	PTHR24247:SF114	5-HYDROXYTRYPTAMINE RECEPTOR 6
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000006342|UniProtKB=H2Q8A8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	TAS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00038	JAK/STAT signaling pathway	P01027	STAT	PANTR|Ensembl=ENSPTRG00000009199|UniProtKB=H2QD19	Signal transducer and activator of transcription	ISS	96210005	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TAKRU|Ensembl=ENSTRUG00000005494|UniProtKB=P53483	Actin, alpha anomalous	IC	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00037	Ionotropic glutamate receptor pathway	P01026	KA	BOVIN|Ensembl=ENSBTAG00000011723|UniProtKB=E1BKL6	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	PANTR|Ensembl=ENSPTRG00000003699|UniProtKB=H2Q3R5	Syntaxin 3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8656|UniProtKB=Q9BZA7	Protocadherin-11 X-linked	IDA	8120095	PubMed	PTHR43912:SF1	PROTOCADHERIN-11 X-LINKED-RELATED
P00019	Endothelin signaling pathway	P00566	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10557357	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00045	Notch signaling pathway	P01116	Delta	HUMAN|HGNC=2907|UniProtKB=P80370	Protein delta homolog 1	ISS			PTHR24052:SF11	PROTEIN DELTA HOMOLOG 1
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02726	Aminobutyrate degradation	P02825	4-aminobutyrate aminotransferase	YEAST|SGD=S000003251|UniProtKB=P17649	4-aminobutyrate aminotransferase	ISS	2190186	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00010	B cell activation	P00384	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	ISS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00006	Apoptosis signaling pathway	P00274	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	ISS	10207617	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00021	FGF signaling pathway	P00641	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	PANTR|Ensembl=ENSPTRG00000001749|UniProtKB=H2Q0Q4	Uncharacterized protein	ISS	11976940	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MACMU|Ensembl=ENSMMUG00000017431|UniProtKB=F7HPP3	Uncharacterized protein	ISS	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00053	T cell activation	P01300	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00005	Angiogenesis	P00223	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00045	Notch signaling pathway	P01105	TACE	MOUSE|MGI=MGI=1096335|UniProtKB=Q9Z0F8	Disintegrin and metalloproteinase domain-containing protein 17	ISS	9774383	PubMed	PTHR11905:SF171	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17
P00021	FGF signaling pathway	P00624	14-3-3	HUMAN|HGNC=12849|UniProtKB=P31946	14-3-3 protein beta/alpha	IGI	10407019	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	TAS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00020	FAS signaling pathway	P00615	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00047	PDGF signaling pathway	P01172	c-Myc	MOUSE|MGI=MGI=97250|UniProtKB=P01108	Myc proto-oncogene protein	ISS	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P05730	Endogenous cannabinoid signaling	P05746	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00019	Endothelin signaling pathway	P00566	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IGI	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00561	STAT	PANTR|Ensembl=ENSPTRG00000009199|UniProtKB=H2QD19	Signal transducer and activator of transcription	ISS	8584036	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00054	Toll receptor signaling pathway	P01355	AP1	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	P17325	SPACC	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00012	Cadherin signaling pathway	P00470	F-actin	STRPU|EnsemblGenome=SPU_006797|UniProtKB=W4XTP5	Uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00034	Integrin signalling pathway	P00932	FAK	PANTR|Ensembl=ENSPTRG00000020624|UniProtKB=H2QWS1	Uncharacterized protein	ISS	9182576	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00045	Notch signaling pathway	P01120	NIcs	HUMAN|HGNC=7881|UniProtKB=P46531	Neurogenic locus notch homolog protein 1	IGI	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00021	FGF signaling pathway	P00632	Akt	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	IGI	9716402	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01369	MKK1	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00059	p53 pathway	P01485	p53	MACMU|Ensembl=ENSMMUG00000008639|UniProtKB=P56424	Cellular tumor antigen p53	TAS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	MOUSE|MGI=MGI=95811|UniProtKB=Q9Z2W8	Glutamate receptor 4	ISS	12871085	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P02747	Histidine biosynthesis	P02992	Imidazol glycerol phosphate synthase	METAC|EnsemblGenome=MA_0541|UniProtKB=Q8TT96	Imidazole glycerol phosphate synthase subunit HisF	ISS			PTHR21235:SF2	IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF
P00057	Wnt signaling pathway	P01435	SWI/SNF	PANTR|Ensembl=ENSPTRG00000005644|UniProtKB=H2R360	Uncharacterized protein	ISS	11532957	PubMed	PTHR10799:SF599	E1A-BINDING PROTEIN P400
P00036	Interleukin signaling pathway	P00974	Receptor subunit beta	MACMU|Gene=CXCR2|UniProtKB=Q28519	C-X-C chemokine receptor type 2 (Fragment)	ISS	10741397	PubMed	PTHR10489:SF689	C-X-C CHEMOKINE RECEPTOR TYPE 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	14707121	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00048	PI3 kinase pathway	P01197	Caspase-9	RAT|RGD=61867|UniProtKB=Q9JHK1	Caspase	ISS	9390557	PubMed	PTHR10454:SF157	CASPASE-9
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	RAT|RGD=70497|UniProtKB=Q05982	Nucleoside diphosphate kinase A	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Ensembl=ENSGALG00000011086|UniProtKB=P68139	Actin, alpha skeletal muscle	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00059	p53 pathway	P04616	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	15531926	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05730	Endogenous cannabinoid signaling	P05746	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	IC	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MACMU|Ensembl=ENSMMUG00000019112|UniProtKB=F6T8S6	N-methyl D-aspartate receptor subtype 2B	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00004	Alzheimer disease-presenilin pathway	P00134	Nectin 1alpha transmembrane fragment	HUMAN|HGNC=9706|UniProtKB=Q15223	Nectin-1	ISS	12376527	PubMed	PTHR23277:SF69	NECTIN-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	PANTR|Ensembl=ENSPTRG00000004718|UniProtKB=H2Q5I0	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00892	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00047	PDGF signaling pathway	P01155	Jak	RAT|RGD=69056|UniProtKB=G3V9W2	Tyrosine-protein kinase	ISS	11929133	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00049	Parkinson disease	P01230	Src kinase	CANLF|Ensembl=ENSCAFG00000017945|UniProtKB=E2RFF7	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00005	Angiogenesis	P00254	GTPase	SCHPO|PomBase=SPAC20H4.11c|UniProtKB=Q9HE04	GTP-binding protein rho5	ISS			PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00034	Integrin signalling pathway	P00922	Collagen	BOVIN|Ensembl=ENSBTAG00000027020|UniProtKB=F1N2Y2	Uncharacterized protein	ISS	10778855	PubMed	PTHR24023:SF539	COLLAGEN ALPHA-2 V  CHAIN
P02750	Lipoate_biosynthesis	P03003	Lipoyl-protein ligase	STRCO|EnsemblGenome=CAD55297|UniProtKB=Q8CK04	Octanoyltransferase	ISS			PTHR10993:SF2	OCTANOYLTRANSFERASE
P00059	p53 pathway	P04623	CBP	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00303	c-Jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00019	Endothelin signaling pathway	P00586	Gq	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02738	De novo purine biosynthesis	P02909	GDP reductase	DEIRA|EnsemblGenome=DR_2374|UniProtKB=Q9RRW1	Ribonucleoside-diphosphate reductase	ISS			PTHR43371:SF1	SUBFAMILY NOT NAMED
P02775	Salvage pyrimidine ribonucleotides	P03156	CDP kinase	MOUSE|MGI=MGI=1931744|UniProtKB=Q99PM9	Uridine-cytidine kinase 2	ISS			PTHR10285:SF70	URIDINE-CYTIDINE KINASE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00034	Integrin signalling pathway	P00948	Rho	CHICK|Ensembl=ENSGALG00000003806|UniProtKB=O93467	GTP-binding protein	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00010	B cell activation	P00373	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IGI	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P02741	Flavin biosynthesis	P02940	Riboflavin synthase	GLOVI|Gene=BAC91545|UniProtKB=Q7NFC2	Riboflavin synthase alpha chain	ISS			PTHR21098:SF0	RIBOFLAVIN SYNTHASE
P00045	Notch signaling pathway	P01114	Ntm	HUMAN|HGNC=7883|UniProtKB=Q9UM47	Neurogenic locus notch homolog protein 3	ISS	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ARATH|TAIR=AT2G42090|UniProtKB=P93738	Putative actin-9	ISS	11889126	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00053	T cell activation	P01307	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	12660731	PubMed	PTHR10048:SF14	PI-3 KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00005	Angiogenesis	P00219	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00036	Interleukin signaling pathway	P00981	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CAEBR|Gene=CBG02401|UniProtKB=A8WUE7	Protein CBR-NMR-1	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	SCLS1|EnsemblGenome=SS1G_03482|UniProtKB=A7EDU2	Guanine nucleotide-binding protein beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CANLF|Ensembl=ENSCAFG00000018564|UniProtKB=E2RHU1	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00053	T cell activation	P01305	Calmodulin	MONDO|Ensembl=ENSMODG00000025146|UniProtKB=F7CLC0	Uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF311	CALMODULIN
P00012	Cadherin signaling pathway	P00470	F-actin	CAEBR|Gene=CBG02161|UniProtKB=A8WS32	Protein CBG02161	ISS	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	MACMU|Ensembl=ENSMMUG00000000304|UniProtKB=F6YVE7	Suppressor of cytokine signaling 4	ISS	10500304	PubMed	PTHR44282:SF2	SUPPRESSOR OF CYTOKINE SIGNALING 4
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	RAT|RGD=2735|UniProtKB=Q63273	Glutamate receptor ionotropic, kainate 5	ISS	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P06664	Gonadotropin-releasing hormone receptor pathway	P06739	MEK1/2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	RCA	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00054	Toll receptor signaling pathway	P01369	MKK1	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00054	Toll receptor signaling pathway	P01356	ERK2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	IDA	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00023	General transcription regulation	P00666	TFIIE	BOVIN|Gene=GTF2E2|UniProtKB=Q2KJF9	General transcription factor IIE subunit 2	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00053	T cell activation	P01306	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IDA	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P00005	Angiogenesis	P00238	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00029	Huntington disease	P00788	Calpain	ANOGA|EnsemblGenome=AGAP010834|UniProtKB=Q7QGN5	AGAP010834-PA	IDA	11675509	PubMed	PTHR10183:SF22	CALPAIN-7
P00005	Angiogenesis	P00182	p38MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00010	B cell activation	P00376	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P05913	Enkephalin release	P05974	G-Protein (i)	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	BOVIN|Ensembl=ENSBTAG00000040439|UniProtKB=F6Q2H9	Uncharacterized protein	ISS	2156831	PubMed	PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P00011	Blood coagulation	P00430	FX	HUMAN|HGNC=3528|UniProtKB=P00742	Coagulation factor X	ISS	4503625	gi	PTHR44064:SF3	COAGULATION FACTOR X
P05916	Opioid prodynorphin pathway	P05999	provasopressin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00053	T cell activation	P01300	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00805	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00219	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IGI	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00034	Integrin signalling pathway	P00944	Actin	HUMAN|HGNC=132|UniProtKB=P60709	Actin, cytoplasmic 1	IPI	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00020	FAS signaling pathway	P00615	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05731	GABA-B receptor II signaling	P05752	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	RCA	176892	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1170702	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04654	Rb	MOUSE|MGI=MGI=97874|UniProtKB=P13405	Retinoblastoma-associated protein	ISS			PTHR13742:SF17	RETINOBLASTOMA-ASSOCIATED PROTEIN
P00005	Angiogenesis	P00251	cPLA2	RAT|RGD=67366|UniProtKB=P50393	Cytosolic phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00054	Toll receptor signaling pathway	P01367	MKK3	MOUSE|MGI=MGI=1346868|UniProtKB=O09110	Dual specificity mitogen-activated protein kinase kinase 3	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CAEBR|Gene=CBG02167|UniProtKB=A8WS37	Protein CBG02167	ISS	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P02779	Thiamin biosynthesis	P03175	1-Deoxyxylulose-5-phosphate synthase	SYNY3|EnsemblGenome=BAA17089|UniProtKB=P73067	1-deoxy-D-xylulose-5-phosphate synthase	ISS			PTHR43322:SF5	1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE 1-RELATED
P00036	Interleukin signaling pathway	P00990	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS			PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00023	General transcription regulation	P00669	TFIIEalpha	RAT|RGD=1306851|UniProtKB=G3V992	General transcription factor II E, polypeptide 1 (Alpha subunit)	ISS	189962	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00006	Apoptosis signaling pathway	P00321	HSP70	CHICK|Ensembl=ENSGALG00000001000|UniProtKB=Q90593	78 kDa glucose-regulated protein	ISS	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	RCA	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04546	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P05918	p38 MAPK pathway	P05919	MAPKAP-K3	MOUSE|MGI=MGI=2143163|UniProtKB=Q3UMW7	MAP kinase-activated protein kinase 3	ISS	11157753	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00220	c-Jun	CHICK|Gene=JUN|UniProtKB=P18870	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00021	FGF signaling pathway	P00645	Rac	MONDO|Ensembl=ENSMODG00000003244|UniProtKB=F6THF0	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IDA	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01227	20S proteasome	DROME|FlyBase=FBgn0016697|UniProtKB=Q95083	Proteasome subunit alpha type-5	TAS	12859888	PubMed	PTHR11599:SF14	PROTEASOME SUBUNIT ALPHA TYPE-5
P00036	Interleukin signaling pathway	P00986	eNOS	PANTR|Ensembl=ENSPTRG00000019868|UniProtKB=H2QVM2	Nitric oxide synthase	ISS	10435050	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00053	T cell activation	P01336	Jnk	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01067	AChE	DANRE|ZFIN=ZDB-GENE-010906-1|UniProtKB=Q9DDE3	Acetylcholinesterase	ISS	87080761	PubMed	PTHR43918:SF3	ACETYLCHOLINESTERASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00705	Gsalpha	CHICK|Ensembl=ENSGALG00000007509|UniProtKB=F1NM72	Uncharacterized protein	ISS	6309844	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P02777	Succinate to proprionate conversion	P03163	Methylmalonyl-CoA decarboxylase	MYCTU|EnsemblGenome=Rv3280|UniProtKB=P9WQH7	Probable propionyl-CoA carboxylase beta chain 5	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P06664	Gonadotropin-releasing hormone receptor pathway	P06821	Atf3	MOUSE|MGI=MGI=109384|UniProtKB=Q60765	Cyclic AMP-dependent transcription factor ATF-3	RCA	11390664	PubMed	PTHR23351:SF23	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-3
P02740	De novo pyrimidine ribonucleotides biosythesis	P02922	Orotate phosphoribosyltransferase	METJA|EnsemblGenome=MJ_1109|UniProtKB=Q58509	Orotate phosphoribosyltransferase	ISS			PTHR19278:SF49	SUBFAMILY NOT NAMED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01284	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00025	Hedgehog signaling pathway	P00685	Smoothened	DROME|FlyBase=FBgn0003444|UniProtKB=P91682	Protein smoothened	IDA	15104233	PubMed	PTHR11309:SF35	SMOOTHENED HOMOLOG
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P06664	Gonadotropin-releasing hormone receptor pathway	P06831	p38	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	RCA	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00010	B cell activation	P00398	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00034	Integrin signalling pathway	P00942	Fyn	TAKRU|Ensembl=ENSTRUG00000003538|UniProtKB=H2S7D1	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF242	TYROSINE-PROTEIN KINASE FYNB
P00006	Apoptosis signaling pathway	P00263	TRAIL	HUMAN|HGNC=11925|UniProtKB=P50591	Tumor necrosis factor ligand superfamily member 10	IDA	12421926	PubMed	PTHR11471:SF27	TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 10
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	MACMU|Ensembl=ENSMMUG00000019917|UniProtKB=F6SEF6	Uncharacterized protein	ISS	11988536	PubMed	PTHR10126:SF20	TATA-BOX-BINDING PROTEIN
P00054	Toll receptor signaling pathway	P01352	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05918	p38 MAPK pathway	P06020	p38delta	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	IC	2372396	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00941	Integrin alpha	MOUSE|MGI=MGI=96599|UniProtKB=Q3V3R4	Integrin alpha-1	ISS	3487386	PubMed	PTHR23220:SF22	INTEGRIN ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	TAS	12885769	PubMed	PTHR10202:SF13	PRESENILIN-2
P00056	VEGF signaling pathway	P01407	Erk	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IDA	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	BRAFL|Gene=BRAFLDRAFT_128184|UniProtKB=C4A0B6	Tyrosine-protein kinase receptor	ISS	11182407	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00021	FGF signaling pathway	P00647	SHP2	PANTR|Ensembl=ENSPTRG00000042397|UniProtKB=H2RIH8	Tyrosine-protein phosphatase non-receptor type	ISS	8096088	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P05731	GABA-B receptor II signaling	P05752	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	BOVIN|Ensembl=ENSBTAG00000014828|UniProtKB=F1N1E0	Uncharacterized protein	ISS	14507926	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	ISS	14765990	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00029	Huntington disease	P00805	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04417	5HT transporter	PANTR|Ensembl=ENSPTRG00000008958|UniProtKB=H2QCL1	Transporter	ISS	14653308	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00005	Angiogenesis	P00223	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00586	Gq	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04395	Vasopressin synthesis	P04597	Signal Peptide	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00057	Wnt signaling pathway	P01451	Galpha	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	HUMAN|HGNC=4597|UniProtKB=P41594	Metabotropic glutamate receptor 5	ISS	9407094	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	YEAST|SGD=S000005098|UniProtKB=P23292	Casein kinase I homolog 2	IDA	11437445	PubMed	PTHR11909:SF117	CASEIN KINASE I HOMOLOG 1-RELATED
P00021	FGF signaling pathway	P00644	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00057	Wnt signaling pathway	P01452	NFAT	CANLF|Ensembl=ENSCAFG00000011625|UniProtKB=F1PDD9	Uncharacterized protein	ISS	12787506	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00045	Notch signaling pathway	P01105	TACE	HUMAN|HGNC=195|UniProtKB=P78536	Disintegrin and metalloproteinase domain-containing protein 17	ISS	12834808	PubMed	PTHR11905:SF171	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00048	PI3 kinase pathway	P01182	Ras	CANAL|EnsemblGenome=CaO19.1760|UniProtKB=Q59XU5	Ras-like protein 1	ISS	99445463	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	MONDO|Ensembl=ENSMODG00000005993|UniProtKB=F6SL91	Uncharacterized protein	ISS			PTHR23409:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 B
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00059	p53 pathway	P04614	Cyclin B	BOVIN|Ensembl=ENSBTAG00000014239|UniProtKB=Q1LZG6	G2/mitotic-specific cyclin-B1	ISS	1019642	gi	PTHR10177:SF193	G2/MITOTIC-SPECIFIC CYCLIN-B1
P00047	PDGF signaling pathway	P01171	PLCgamma	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00629	PP2A	YEAST|SGD=S000002482|UniProtKB=P32345	Serine/threonine-protein phosphatase 4 catalytic subunit	ISS			PTHR11668:SF22	SERINE/THREONINE-PROTEIN PHOSPHATASE 4 CATALYTIC SUBUNIT
P02783	Tryptophan biosynthesis	P03211	Phosphribosyl anthranilate isomerase	ARATH|TAIR=AT1G29410|UniProtKB=Q8LPI9	N-(5'-phosphoribosyl)anthranilate isomerase 3, chloroplastic	ISS			PTHR42894:SF1	N- 5'-PHOSPHORIBOSYL ANTHRANILATE ISOMERASE
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MOUSE|MGI=MGI=102705|UniProtKB=P63213	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	TAKRU|Ensembl=ENSTRUG00000003442|UniProtKB=H2S6Q5	Uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF197	CALMODULIN-LIKE PROTEIN 3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DANRE|ZFIN=ZDB-GENE-041210-195|UniProtKB=F1R506	Protein kinase C	ISS	11880265	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	HUMAN|HGNC=4581|UniProtKB=Q13003	Glutamate receptor ionotropic, kainate 3	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06587	Nicotine pharmacodynamics pathway	P06605	KCNK3/9	MACMU|Ensembl=ENSMMUG00000005826|UniProtKB=F6VE51	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00018	EGF receptor signaling pathway	P00550	Grb2	CAEBR|Gene=CBG16856|UniProtKB=A8XPY6	Protein CBR-SEM-5	ISS	17569445	gi	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00053	T cell activation	P01336	Jnk	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	YEAST|SGD=S000000950|UniProtKB=P13393	TATA-box-binding protein	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IGI	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	MACMU|Ensembl=ENSMMUG00000031831|UniProtKB=F7HQI5	Interleukin-23 subunit alpha	ISS	11114383	PubMed	PTHR15947:SF0	INTERLEUKIN-23 SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00049	Parkinson disease	P01210	UCH-L1	PANTR|Ensembl=ENSPTRG00000016009|UniProtKB=H2QPD6	Ubiquitin carboxyl-terminal hydrolase	ISS	12408865	PubMed	PTHR10589:SF19	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L1
P00008	Axon guidance mediated by Slit/Robo	P00351	Cxcr4	DANRE|ZFIN=ZDB-GENE-010614-1|UniProtKB=Q9PTF7	Chemokine receptor CXCR4	ISS	4503175	gi	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P00006	Apoptosis signaling pathway	P00322	Cytochrome C	ORYSJ|EnsemblGenome=OS01G0885000|UniProtKB=Q8S0R8	Os01g0885000 protein	ISS			PTHR11961:SF9	CYTOCHROME C-1-RELATED
P04393	Ras Pathway	P04570	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00923	Arf1	DANRE|ZFIN=ZDB-GENE-010724-5|UniProtKB=Q803D1	ADP-ribosylation factor 1	ISS	11752622	PubMed	PTHR11711:SF294	ADP-RIBOSYLATION FACTOR 3
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00056	VEGF signaling pathway	P01401	HIF-1	MOUSE|MGI=MGI=106918|UniProtKB=Q61221	Hypoxia-inducible factor 1-alpha	ISS	14526383	PubMed	PTHR23043:SF7	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IPI	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=1309999|UniProtKB=Q922R0	cAMP-dependent protein kinase catalytic subunit PRKX	IC	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00020	FAS signaling pathway	P00595	Caspase7	BOVIN|Ensembl=ENSBTAG00000006615|UniProtKB=F1MD58	Uncharacterized protein	ISS	14583630	PubMed	PTHR10454:SF31	CASPASE-7
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00057	Wnt signaling pathway	P01465	Ggamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00047	PDGF signaling pathway	P01162	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	CAEEL|WormBase=WBGene00001615|UniProtKB=Q17697	GLutamate Receptor family (AMPA)	ISS	10331083	PubMed	PTHR18966:SF352	GLUTAMATE RECEPTOR FAMILY  AMPA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g210933|UniProtKB=A7SEA7	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00048	PI3 kinase pathway	P01177	P110ACT	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00382	Syk	CANLF|Ensembl=ENSCAFG00000002171|UniProtKB=F1PSC8	Tyrosine-protein kinase	ISS	8137818	PubMed	PTHR24418:SF231	TYROSINE-PROTEIN KINASE SYK
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000017333|UniProtKB=Q5DRD0	Protocadherin beta-4	ISS	8120095	PubMed	PTHR24028:SF55	PROTOCADHERIN BETA-4
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	DROME|FlyBase=FBgn0001991|UniProtKB=Q24270	Voltage-dependent calcium channel type D subunit alpha-1	IC	9199552	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00030	Hypoxia response via HIF activation	P00819	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	HUMAN|HGNC=1388|UniProtKB=O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	8386525	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	RCA			PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00021	FGF signaling pathway	P00638	PLCgamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00029	Huntington disease	P00807	Actin	CHICK|Gene=ACTA2|UniProtKB=P08023	Actin, aortic smooth muscle	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00029	Huntington disease	P00790	beta-Tubulin	LEIMA|EnsemblGenome=LmjF.21.1860|UniProtKB=Q4QBZ6	Beta tubulin	TAS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	MACMU|Ensembl=ENSMMUG00000010574|UniProtKB=A5A6H2	C-fos	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00029	Huntington disease	P00774	Dynein complex	BOVIN|Ensembl=ENSBTAG00000000458|UniProtKB=F1MBQ0	Uncharacterized protein	ISS	9454836	PubMed	PTHR12688:SF1	CYTOPLASMIC DYNEIN 1 LIGHT INTERMEDIATE CHAIN 2
P00047	PDGF signaling pathway	P01145	c-fos	MONDO|Ensembl=ENSMODG00000005927|UniProtKB=F6WX28	Uncharacterized protein	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00007	Axon guidance mediated by semaphorins	P00340	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	15470041	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	RAT|RGD=619751|UniProtKB=O88302	Guanine nucleotide-binding protein subunit alpha-15	ISS	8838318	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P00012	Cadherin signaling pathway	P00470	F-actin	DICDI|dictyBase=DDB_G0289489|UniProtKB=P07828	Actin-18	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00048	PI3 kinase pathway	P01177	P110ACT	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	RCA	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00551	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04393	Ras Pathway	P04547	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	XENTR|Xenbase=XB-GENE-966302|UniProtKB=F6T2E7	Uncharacterized protein	ISS	10644687	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	RCA	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00029	Huntington disease	P00774	Dynein complex	ANOGA|Gene=AgaP_AGAP010435|UniProtKB=Q5TUD8	AGAP010435-PA (Fragment)	IPI	9454836	PubMed	PTHR10676:SF347	DYNEIN HEAVY CHAIN AT 93AB, ISOFORM C
P00005	Angiogenesis	P00219	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=7464|UniProtKB=P49286	Melatonin receptor type 1B	IDA			PTHR43962:SF6	MELATONIN RECEPTOR TYPE 1B
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00034	Integrin signalling pathway	P00910	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	10521483	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Ensembl=ENSPTRG00000013825|UniProtKB=H2RAK4	Uncharacterized protein	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00046	Oxidative stress response	P01129	JNK1/2	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04375	5HT3 type receptor mediated signaling pathway	P04421	5HT transporter	MACMU|Gene=SLC6A4|UniProtKB=Q9MYX0	Sodium-dependent serotonin transporter	ISS	14653308	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00052	TGF-beta signaling pathway	P01284	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00556	PLCgamma	CAEEL|WormBase=WBGene00004038|UniProtKB=Q22070	Phosphoinositide phospholipase C	ISS			PTHR10336:SF91	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00018	EGF receptor signaling pathway	P00551	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IGI	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	TAS	7600581	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	9009705	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00047	PDGF signaling pathway	P01171	PLCgamma	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P02731	Biotin biosynthesis	P02858	8-Amino-7-oxononanoate synthase	BACSU|EnsemblGenome=BSU17000|UniProtKB=O31777	8-amino-7-oxononanoate synthase 1	ISS			PTHR13693:SF77	8-AMINO-7-OXONONANOATE SYNTHASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MOUSE|MGI=MGI=108482|UniProtKB=P97292	Histamine H2 receptor	IDA	8817552	PubMed	PTHR43893:SF5	HISTAMINE H2 RECEPTOR
P05918	p38 MAPK pathway	P06020	p38delta	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	RCA	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1712|UniProtKB=Q6PBY0	Guanine nucleotide binding protein (G protein), beta 5	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00005	Angiogenesis	P00238	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00029	Huntington disease	P00780	Microtubule	BATDJ|Gene=BATDEDRAFT_15405|UniProtKB=F4NUL6	Alpha-Beta tubulin	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MACMU|Ensembl=ENSMMUG00000016751|UniProtKB=F7AIB6	Mitogen-activated protein kinase kinase kinase 3 isoform 1	ISS	8649450	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00046	Oxidative stress response	P01126	ATF2	HUMAN|HGNC=784|UniProtKB=P15336	Cyclic AMP-dependent transcription factor ATF-2	TAS	11390664	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IDA	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00056	VEGF signaling pathway	P01407	Erk	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00561	STAT	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	14984365	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IC	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00012	Cadherin signaling pathway	P00471	Cadherin	CHICK|Gene=CDHR1|UniProtKB=Q8UVJ7	Cadherin-related family member 1	IDA	8120095	PubMed	PTHR44506:SF1	CADHERIN-RELATED FAMILY MEMBER 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	DICPU|Gene=DICPUDRAFT_93216|UniProtKB=F1A421	Guanine nucleotide-binding protein subunit beta	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00015	Circadian clock system	P00504	Per	MACMU|Ensembl=ENSMMUG00000021798|UniProtKB=F7ESU2	Uncharacterized protein	ISS	20570170	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P00017	DNA replication	P00527	Histones	PLAF7|EnsemblGenome=PFF0865w|UniProtKB=C6KT19	Histone H3	ISS	12413958	PubMed	PTHR11426:SF169	HISTONE H3
P00029	Huntington disease	P00789	PSD-95	MOUSE|MGI=MGI=1277959|UniProtKB=Q62108	Disks large homolog 4	TAS	12932731	PubMed	PTHR23119:SF33	DISKS LARGE HOMOLOG 4
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	TAS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P02748	Isoleucine biosynthesis	P02995	Threonine dehydratase	PSEAE|EnsemblGenome=PA0331|UniProtKB=Q9I6G0	L-threonine dehydratase	ISS			PTHR43714:SF1	THREONINE DEHYDRATASE, MITOCHONDRIAL
P00019	Endothelin signaling pathway	P00566	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	CHICK|Ensembl=ENSGALG00000003806|UniProtKB=O93467	GTP-binding protein	ISS	12169092	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	IDA	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00012	Cadherin signaling pathway	P00470	F-actin	TRIAD|EnsemblGenome=TriadG56111|UniProtKB=B3RX77	Non-muscle actin 6.2	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02738	De novo purine biosynthesis	P02911	N5-carboxyaminoimidazole ribonucleotide mutase	LEPIN|EnsemblGenome=LA_1463|UniProtKB=Q8F649	N5-carboxyaminoimidazole ribonucleotide mutase	ISS			PTHR23046:SF2	N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE MUTASE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	IDA	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BOVIN|Gene=ACTG2|UniProtKB=Q5E9B5	Actin, gamma-enteric smooth muscle	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00052	TGF-beta signaling pathway	P01284	JNK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	TAS	10207617	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00005	Angiogenesis	P00243	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	HUMAN|HGNC=7574|UniProtKB=Q9Y623	Myosin-4	ISS	10938134	PubMed	PTHR13140:SF681	MYOSIN-4
P00034	Integrin signalling pathway	P00920	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	YEAST|SGD=S000000027|UniProtKB=P32492	Myosin-4	IC			PTHR13140:SF725	DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	RAT|RGD=2738|UniProtKB=Q00960	Glutamate receptor ionotropic, NMDA 2B	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P02744	Fructose galactose metabolism	P02966	Hexokinase	YEAST|SGD=S000004438|UniProtKB=Q06204	Putative hexokinase YLR446W	IEA	9169871	PubMed	PTHR19443:SF24	HEXOKINASE YLR446W-RELATED
P00005	Angiogenesis	P00243	Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	ISS	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	PANTR|Ensembl=ENSPTRG00000006218|UniProtKB=H2Q834	Uncharacterized protein	ISS	12787506	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00029	Huntington disease	P00796	Kainate receptor	RAT|RGD=2732|UniProtKB=P22756	Glutamate receptor ionotropic, kainate 1	IDA	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00005	Angiogenesis	P00211	GSK3beta	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01164	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MOUSE|MGI=MGI=107813|UniProtKB=Q9ERD7	Tubulin beta-3 chain	ISS	12932731	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	PANTR|Ensembl=ENSPTRG00000000843|UniProtKB=H2QZN8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P06664	Gonadotropin-releasing hormone receptor pathway	P06812	L-type Ca2+	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	RCA	11956331	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	IDA	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	CHICK|Gene=CHRNA7|UniProtKB=P22770	Neuronal acetylcholine receptor subunit alpha-7	ISS	85270494	PubMed	PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P05918	p38 MAPK pathway	P06035	TAB1	CANLF|Ensembl=ENSCAFG00000001332|UniProtKB=F1PLP7	Uncharacterized protein	ISS	10838074	PubMed	PTHR13832:SF533	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1
P00021	FGF signaling pathway	P00641	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04393	Ras Pathway	P04547	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P04392	P53 pathway feedback loops 1	P04537	p73DeltaN	BOVIN|Ensembl=ENSBTAG00000015460|UniProtKB=F1MKA9	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00025	Hedgehog signaling pathway	P00690	Cubitus interruptus	MACMU|Ensembl=ENSMMUG00000022058|UniProtKB=F7HP77	Uncharacterized protein	ISS			PTHR19818:SF2	ZINC FINGER PROTEIN GLI1
P00048	PI3 kinase pathway	G01544	GADD45	MOUSE|MGI=MGI=107799|UniProtKB=P48316	Growth arrest and DNA damage-inducible protein GADD45 alpha	ISS	7509226	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	BOVIN|Ensembl=ENSBTAG00000004129|UniProtKB=Q9TTS6	Eotaxin	ISS			PTHR12015:SF146	EOTAXIN
P00059	p53 pathway	G01574	ARF	MACMU|Ensembl=ENSMMUG00000011953|UniProtKB=F7HID8	Cyclin-dependent kinase 4 inhibitor D	ISS			PTHR24148:SF47	CYCLIN-DEPENDENT KINASE 4 INHIBITOR B-RELATED
P00057	Wnt signaling pathway	P01428	Frizzled	MOUSE|MGI=MGI=108460|UniProtKB=Q61091	Frizzled-8	IDA	11212302	PubMed	PTHR11309:SF90	FRIZZLED-8
P00030	Hypoxia response via HIF activation	P00819	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04559	Rac	ARATH|TAIR=AT5G45970|UniProtKB=Q38903	Rac-like GTP-binding protein ARAC2	ISS	12932731	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P02788	Xanthine and guanine salvage pathway	P03247	Xanthine phosphoribosyl transferase	MACMU|Ensembl=ENSMMUG00000008303|UniProtKB=F7H6Y5	Uncharacterized protein	ISS			PTHR43340:SF6	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	IC	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	IC	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	HUMAN|HGNC=4586|UniProtKB=Q13224	Glutamate receptor ionotropic, NMDA 2B	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	MACMU|Ensembl=ENSMMUG00000014626|UniProtKB=F7GNE5	Uncharacterized protein	ISS			PTHR42884:SF13	NEUROENDOCRINE CONVERTASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00944	Actin	MONDO|Ensembl=ENSMODG00000024992|UniProtKB=F6TUR3	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00059	p53 pathway	P01486	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01369	MKK1	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	XENTR|Xenbase=XB-GENE-480551|UniProtKB=F6XVE6	Uncharacterized protein (Fragment)	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00059	p53 pathway	P01486	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	MONDO|Ensembl=ENSMODG00000025188|UniProtKB=F7C1G3	Uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06959	CCKR signaling map	P07231	Pro-caspase-3	HUMAN|HGNC=1504|UniProtKB=P42574	Caspase-3	RCA	17936584	PubMed	PTHR10454:SF198	CASPASE-3
P00010	B cell activation	P00381	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00516	Ena/VASP	RAT|RGD=621150|UniProtKB=O08719	Ena/VASP-like protein	ISS			PTHR11202:SF4	ENA/VASP-LIKE PROTEIN
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	MONDO|Ensembl=ENSMODG00000015793|UniProtKB=F7FS26	Uncharacterized protein	ISS			PTHR11405:SF38	CARBAMOYL-PHOSPHATE SYNTHASE  AMMONIA , MITOCHONDRIAL
P00018	EGF receptor signaling pathway	P00547	PP2A	TRIAD|EnsemblGenome=TriadG63380|UniProtKB=B3S653	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04547	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00019	Endothelin signaling pathway	P00572	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00047	PDGF signaling pathway	P01140	ELK	MOUSE|MGI=MGI=102853|UniProtKB=P41158	ETS domain-containing protein Elk-4	ISS	11846562	PubMed	PTHR11849:SF21	ETS DOMAIN-CONTAINING PROTEIN ELK-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00018	EGF receptor signaling pathway	P00542	EGFR	TAKRU|Ensembl=ENSTRUG00000010319|UniProtKB=H2TMR9	Uncharacterized protein (Fragment)	ISS	3170544	gi	PTHR24416:SF382	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00908	p130CAS	CANLF|Ensembl=ENSCAFG00000020081|UniProtKB=F1P9X8	Uncharacterized protein	ISS	8649368	PubMed	PTHR10654:SF15	BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 1
P00021	FGF signaling pathway	P00626	Spry	RAT|RGD=1311472|UniProtKB=Q5HZA2	Protein Spry2	ISS	12402043	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	CANLF|Ensembl=ENSCAFG00000007357|UniProtKB=F1PPK6	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00020	FAS signaling pathway	P00601	c-Jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00018	EGF receptor signaling pathway	P00548	RKIP	MOUSE|MGI=MGI=1923650|UniProtKB=Q8VIN1	Phosphatidylethanolamine-binding protein 2	IGI			PTHR11362:SF8	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 2
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00049	Parkinson disease	P01238	14-3-3	MACMU|Ensembl=ENSMMUG00000013206|UniProtKB=F6XFG9	14-3-3 protein beta/alpha	ISS	10407019	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01448	CBP	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P02777	Succinate to proprionate conversion	P03163	Methylmalonyl-CoA decarboxylase	RAT|RGD=3265|UniProtKB=P07633	Propionyl-CoA carboxylase beta chain, mitochondrial	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=2388285|UniProtKB=Q8K045	Serine/threonine-protein kinase N3	IC	11880265	PubMed	PTHR24356:SF175	SERINE/THREONINE-PROTEIN KINASE N3
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	RAT|RGD=1304749|UniProtKB=A0A0G2K0H3	Protein Lrp6	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00057	Wnt signaling pathway	P01443	Phospholipase C	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00047	PDGF signaling pathway	P01142	p90RSK	PANTR|Ensembl=ENSPTRG00000006631|UniProtKB=H2Q8S3	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF115	RIBOSOMAL PROTEIN S6 KINASE ALPHA-5
P04393	Ras Pathway	P04578	Rho	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	ISS	12039949	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00045	Notch signaling pathway	P01110	Presenilin	CANLF|Gene=PSEN1|UniProtKB=Q6RH31	Presenilin-1	ISS	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P04398	p53 pathway feedback loops 2	P04660	SIAH-1	MACMU|Ensembl=ENSMMUG00000007400|UniProtKB=F6T3K3	E3 ubiquitin-protein ligase	ISS	14985507	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00056	VEGF signaling pathway	P01423	p38MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00049	Parkinson disease	P01242	Casein kinase I	CANLF|Ensembl=ENSCAFG00000019435|UniProtKB=E2QX25	Uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF157	CASEIN KINASE I ISOFORM GAMMA-2
P00018	EGF receptor signaling pathway	P00560	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P06664	Gonadotropin-releasing hormone receptor pathway	P06834	MAP3Ks	MOUSE|MGI=MGI=1346873|UniProtKB=Q61083	Mitogen-activated protein kinase kinase kinase 2	RCA	8649450	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00005	Angiogenesis	P00197	Grb14	HUMAN|HGNC=4565|UniProtKB=Q14449	Growth factor receptor-bound protein 14	IDA	10521483	PubMed	PTHR11243:SF22	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 14
P00010	B cell activation	P00371	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	RCA	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00015	Circadian clock system	G01503	per	MOUSE|MGI=MGI=1277134|UniProtKB=O70361	Period circadian protein homolog 3	ISS	98372739	PubMed	PTHR11269:SF13	PERIOD CIRCADIAN PROTEIN HOMOLOG 3
P00056	VEGF signaling pathway	P01417	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	BOVIN|Ensembl=ENSBTAG00000001067|UniProtKB=E1BAB4	Uncharacterized protein	ISS	20012997	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P05730	Endogenous cannabinoid signaling	P05751	Galpha	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000002016|UniProtKB=F1P3G1	Protein kinase C delta type	ISS	11880265	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00049	Parkinson disease	P01236	Casein kinase II	RAT|RGD=621663|UniProtKB=P19139	Casein kinase II subunit alpha	IDA	10806215	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P04398	p53 pathway feedback loops 2	P04657	P110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01162	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00036	Interleukin signaling pathway	P00973	PKB	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01171	PLCgamma	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	ANOGA|EnsemblGenome=AGAP006475|UniProtKB=Q5TQX0	AGAP006475-PA	ISS	12880387	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	RAT|RGD=2734|UniProtKB=Q01812	Glutamate receptor ionotropic, kainate 4	ISS	12941441	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00035	Interferon-gamma signaling pathway	P00956	SOCS	MACMU|Ensembl=ENSMMUG00000012671|UniProtKB=F7E320	Suppressor of cytokine signaling 2	ISS	15032587	PubMed	PTHR44396:SF2	SUPPRESSOR OF CYTOKINE SIGNALING 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	ANOGA|EnsemblGenome=AGAP010589|UniProtKB=Q7Q8S4	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF3	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA-RELATED
P04393	Ras Pathway	P04542	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00054	Toll receptor signaling pathway	G01550	Gene trancription	MOUSE|MGI=MGI=107936|UniProtKB=P70380	Interleukin-18	ISS	11123331	PubMed	PTHR45200:SF1	INTERLEUKIN-18
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	TAS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00059	p53 pathway	G01563	MDM-2	PANTR|Ensembl=ENSPTRG00000001889|UniProtKB=H2R875	Mdm4 p53 binding protein homolog	ISS			PTHR13844:SF20	PROTEIN MDM4
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MACMU|Ensembl=ENSMMUG00000018272|UniProtKB=F7HEB8	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00053	T cell activation	P01300	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01311	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01143	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00644	p38	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	IGI	20451058	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	IDA	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02775	Salvage pyrimidine ribonucleotides	P03155	Cytosine deaminase	MOUSE|MGI=MGI=1914007|UniProtKB=Q6P6J0	tRNA-specific adenosine deaminase 2	ISS			PTHR11079:SF92	TRNA-SPECIFIC ADENOSINE DEAMINASE 2
P00049	Parkinson disease	P01235	Fyn kinase	MOUSE|MGI=MGI=95602|UniProtKB=P39688	Tyrosine-protein kinase Fyn	IDA	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00049	Parkinson disease	P01211	ERK	DICDI|dictyBase=DDB_G0283903|UniProtKB=Q54QB1	Extracellular signal-regulated kinase 2	IDA	10514528	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00060	Ubiquitin proteasome pathway	P01490	E3	BOVIN|Ensembl=ENSBTAG00000000308|UniProtKB=F1MGQ5	Uncharacterized protein	ISS			PTHR11254:SF66	E3 UBIQUITIN-PROTEIN LIGASE ITCHY HOMOLOG
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2520|UniProtKB=P61169	D(2) dopamine receptor	IDA	11861492	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00010	B cell activation	P00402	Jnk	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00053	T cell activation	P01307	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	IPI	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	XENTR|Xenbase=XB-GENE-493706|UniProtKB=Q28IC7	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P04398	p53 pathway feedback loops 2	P04665	AKT	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	ISS	12655147	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00807	Actin	ORNAN|Ensembl=ENSOANG00000007716|UniProtKB=F6UDX9	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00048	PI3 kinase pathway	P01179	PKB	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MACMU|Ensembl=ENSMMUG00000009679|UniProtKB=F6YBQ8	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00034	Integrin signalling pathway	P00916	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P02740	De novo pyrimidine ribonucleotides biosythesis	P02927	Dihydrooratate oxidase	PSEAE|EnsemblGenome=PA3050|UniProtKB=Q9HZF8	Dihydroorotate dehydrogenase (quinone)	ISS			PTHR43517:SF1	DIHYDROOROTATE DEHYDROGENASE  QUINONE , MITOCHONDRIAL
P00005	Angiogenesis	P00187	beta catenin	ORNAN|Ensembl=ENSOANG00000006811|UniProtKB=F6WBD5	Uncharacterized protein	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00965	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IC	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000010521|UniProtKB=F7DQK7	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00029	Huntington disease	P00807	Actin	CAEEL|WormBase=WBGene00000067|UniProtKB=O45815	ACTin	IDA	10974003	PubMed	PTHR11937:SF352	ACTIN
P04393	Ras Pathway	P04559	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	10891487	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00054	Toll receptor signaling pathway	P01356	ERK2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00799	JNK-2	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MACMU|Ensembl=ENSMMUG00000007027|UniProtKB=F7F210	Alpha-cardiac actin	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	PSEAE|EnsemblGenome=PA4756|UniProtKB=P38100	Carbamoyl-phosphate synthase large chain	ISS			PTHR11405:SF5	CAD PROTEIN
P00010	B cell activation	P00402	Jnk	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00005	Angiogenesis	P00188	Ets	MOUSE|MGI=MGI=95455|UniProtKB=P27577	Protein C-ets-1	ISS	15579511	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00006	Apoptosis signaling pathway	P00269	MAPK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00048	PI3 kinase pathway	P01202	p85	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	IGI	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	ISS	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P00021	FGF signaling pathway	P00623	FGF	MONDO|Ensembl=ENSMODG00000018899|UniProtKB=P48798	Fibroblast growth factor 2	ISS			PTHR11486:SF83	FIBROBLAST GROWTH FACTOR 2
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000016438|UniProtKB=F7GTQ2	Serine/threonine-protein kinase	ISS	12676944	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P00053	T cell activation	P01306	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	MONDO|Ensembl=ENSMODG00000002847|UniProtKB=F7B627	Uncharacterized protein (Fragment)	ISS	11907044	PubMed	PTHR44025:SF7	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	HUMAN|HGNC=1401|UniProtKB=Q02641	Voltage-dependent L-type calcium channel subunit beta-1	ISS	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00005	Angiogenesis	P00217	STAT3	PANTR|Ensembl=ENSPTRG00000009200|UniProtKB=H2QD20	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00034	Integrin signalling pathway	P00942	Fyn	PANTR|Ensembl=ENSPTRG00000018511|UniProtKB=H2QTK7	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	IDA	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P05731	GABA-B receptor II signaling	P05758	K channel	CHICK|Gene=KCNJ3|UniProtKB=Q90854	G protein-activated inward rectifier potassium channel 1	RCA	2433589	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_127490|UniProtKB=C3XYC5	Putative uncharacterized protein	IDA	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00005	Angiogenesis	P00217	STAT3	PANTR|Ensembl=ENSPTRG00000009200|UniProtKB=H2QD20	Signal transducer and activator of transcription	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00029	Huntington disease	P00810	GAPDH	CAEEL|WormBase=WBGene00001686|UniProtKB=P17331	Glyceraldehyde-3-phosphate dehydrogenase 4	IPI			PTHR10836:SF65	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE 1-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00047	PDGF signaling pathway	P01167	Ets	HUMAN|HGNC=3317|UniProtKB=Q15723	ETS-related transcription factor Elf-2	ISS	15298723	PubMed	PTHR11849:SF10	ETS-RELATED TRANSCRIPTION FACTOR ELF-2
P00036	Interleukin signaling pathway	P00990	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IC	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00046	Oxidative stress response	P01138	MKK4	CHICK|Ensembl=ENSGALG00000001001|UniProtKB=F1P3T1	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00053	T cell activation	P01312	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	HUMAN|HGNC=130|UniProtKB=P62736	Actin, aortic smooth muscle	IC	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00020	FAS signaling pathway	P00620	CytochromeC	CANLF|Ensembl=ENSCAFG00000001529|UniProtKB=E2REM0	Uncharacterized protein	ISS	9027315	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	IC	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00019	Endothelin signaling pathway	P00570	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	MACMU|Ensembl=ENSMMUG00000013057|UniProtKB=F7H5N9	Uncharacterized protein	ISS			PTHR11699:SF207	ALDEHYDE DEHYDROGENASE X, MITOCHONDRIAL
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00057	Wnt signaling pathway	P01448	CBP	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P05912	Dopamine receptor mediated signaling pathway	P05960	VAT2	PANTR|Ensembl=ENSPTRG00000002979|UniProtKB=H2Q2M8	Uncharacterized protein	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00034	Integrin signalling pathway	P00906	Rap1	RAT|RGD=1359694|UniProtKB=P62836	Ras-related protein Rap-1A	ISS	1904317	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00035	Interferon-gamma signaling pathway	P00956	SOCS	CANLF|Ensembl=ENSCAFG00000010293|UniProtKB=F1PSF4	Uncharacterized protein	ISS	15032587	PubMed	PTHR44649:SF1	CYTOKINE-INDUCIBLE SH2-CONTAINING PROTEIN
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00009	Axon guidance mediated by netrin	P00361	Ena	HUMAN|HGNC=12652|UniProtKB=P50552	Vasodilator-stimulated phosphoprotein	ISS			PTHR11202:SF12	VASODILATOR-STIMULATED PHOSPHOPROTEIN
P02753	Methionine biosynthesis	P03023	Homoserine succinyltransferase	ECOLI|EcoGene=EG10581|UniProtKB=P07623	Homoserine O-succinyltransferase	ISS			PTHR20919:SF0	HOMOSERINE O-SUCCINYLTRANSFERASE
P00050	Plasminogen activating cascade	P01254	pro-MMP-13	BOVIN|Gene=MMP13|UniProtKB=O77656	Collagenase 3	ISS	Fang,Y.,Kitchell,B.E.,Paria,B.andBalkin,R.	free text	PTHR10201:SF165	COLLAGENASE 3
P00036	Interleukin signaling pathway	P00965	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02775	Salvage pyrimidine ribonucleotides	P03149	Cytidine kinase	MACMU|Ensembl=ENSMMUG00000009976|UniProtKB=F6R3B0	Uridine-cytidine kinase	ISS			PTHR10285:SF66	URIDINE-CYTIDINE KINASE 1
P04398	p53 pathway feedback loops 2	G04709	MDM-2	CANLF|Ensembl=ENSCAFG00000009669|UniProtKB=E2RDT3	Uncharacterized protein	ISS			PTHR13844:SF20	PROTEIN MDM4
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS			PTHR24353:SF49	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MACMU|Ensembl=ENSMMUG00000017683|UniProtKB=F6UA63	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01159	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P02746	Heme biosynthesis	P02983	Hydroxymethylbilane synthase	HALSA|EnsemblGenome=VNG_2330G|UniProtKB=Q9HMY5	Probable porphobilinogen deaminase	ISS			PTHR11557:SF0	PORPHOBILINOGEN DEAMINASE
P05731	GABA-B receptor II signaling	P05758	K channel	RAT|RGD=2958|UniProtKB=P63251	G protein-activated inward rectifier potassium channel 1	ISS	12374786	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00034	Integrin signalling pathway	P00910	Grb2	BOVIN|Ensembl=ENSBTAG00000003707|UniProtKB=A6QLK6	GRB2-related adapter protein	ISS	8051109	PubMed	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	BRADU|Gene=BAC52761|UniProtKB=Q89DE3	tRNA-specific adenosine deaminase	ISS			PTHR11079:SF149	TRNA-SPECIFIC ADENOSINE DEAMINASE
P02749	Leucine biosynthesis	P02999	2-Isopropylmalate synthase	ARATH|TAIR=AT5G23020|UniProtKB=Q9FN52	Methylthioalkylmalate synthase 3, chloroplastic	ISS			PTHR10277:SF9	2-ISOPROPYLMALATE SYNTHASE 1, CHLOROPLASTIC-RELATED
P02729	Ascorbate degradation	P02852	L-xylulose-5-phosphate-3-epimerase	CHLTR|EnsemblGenome=CT_121|UniProtKB=O84123	Ribulose-phosphate 3-epimerase	ISS			PTHR11749:SF3	RIBULOSE-PHOSPHATE 3-EPIMERASE
P00019	Endothelin signaling pathway	P00590	IP3 R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	TAKRU|Ensembl=ENSTRUG00000003520|UniProtKB=H2S791	Uncharacterized protein	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00048	PI3 kinase pathway	P01192	p110	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000014173|UniProtKB=H2QLD7	Adenosine receptor A2	ISS			PTHR24246:SF27	ADENOSINE RECEPTOR A2A
P00012	Cadherin signaling pathway	P00471	Cadherin	ANOGA|EnsemblGenome=AGAP007905|UniProtKB=Q7Q3J3	AGAP007905-PA (Fragment)	ISS			PTHR43956:SF7	CADHERIN-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MACMU|Ensembl=ENSMMUG00000006421|UniProtKB=F6U2K7	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P00021	FGF signaling pathway	P00624	14-3-3	RAT|RGD=3980|UniProtKB=P63102	14-3-3 protein zeta/delta	ISS	1499718	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00020	FAS signaling pathway	P00615	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00633	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IGI	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00012	Cadherin signaling pathway	P00470	F-actin	STRPU|EnsemblGenome=SPU_026078|UniProtKB=W4ZD41	Uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF277	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02756	N-acetylglucosamine metabolism	P03036	N-acetylglucosamine-6-phosphate deacetylase	DEIRA|EnsemblGenome=DR_A0066|UniProtKB=Q9RZ88	N-acetylglucosamine-6-phosphate deacetylase	ISS			PTHR11113:SF1	N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE
P00048	PI3 kinase pathway	P01188	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000003762|UniProtKB=A5PJS1	GNB5 protein	ISS	1499560	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	PYRAE|EnsemblGenome=PAE3155|UniProtKB=Q8ZTP7	Ribonucleotide reductase	ISS			PTHR43371:SF1	SUBFAMILY NOT NAMED
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	ENTHI|EnsemblGenome=EHI_181250|UniProtKB=C4M5Z7	Rho family GTPase	ISS	97082968	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00010	B cell activation	P00376	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04395	Vasopressin synthesis	P04589	Signal Peptidase	CHICK|Ensembl=ENSGALG00000002839|UniProtKB=F1NAZ9	Signal peptidase complex catalytic subunit SEC11	ISS	2674115	PubMed	PTHR10806:SF12	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11C
P06587	Nicotine pharmacodynamics pathway	P06597	CDK5	TAKRU|Ensembl=ENSTRUG00000004034|UniProtKB=H2SAY8	Uncharacterized protein	ISS	12372285	PubMed	PTHR24056:SF46	CYCLIN-DEPENDENT-LIKE KINASE 5
P00053	T cell activation	P01319	PAK	RAT|RGD=3250|UniProtKB=P35465	Serine/threonine-protein kinase PAK 1	ISS	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00005	Angiogenesis	P00238	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00010	B cell activation	P00397	IKK	CANLF|Ensembl=ENSCAFG00000005526|UniProtKB=E2RKR0	Uncharacterized protein	ISS	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00036	Interleukin signaling pathway	P00973	PKB	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00010	B cell activation	P00402	Jnk	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01465	Ggamma	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00046	Oxidative stress response	P01131	MKP5	MOUSE|MGI=MGI=2685183|UniProtKB=Q1HL35	Dual specificity protein phosphatase	TAS			PTHR10159:SF40	DUAL SPECIFICITY PROTEIN PHOSPHATASE 5
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=1930705|UniProtKB=P61264	Syntaxin-1B	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00012	Cadherin signaling pathway	P00470	F-actin	PANTR|Ensembl=ENSPTRG00000018890|UniProtKB=Q5R1X3	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00010	B cell activation	P00385	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12932731	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00005	Angiogenesis	P00200	Dsh	CHICK|Ensembl=ENSGALG00000008414|UniProtKB=F1P5N3	Uncharacterized protein	ISS	11212302	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P00030	Hypoxia response via HIF activation	P00819	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000005238|UniProtKB=F7BWT2	Uncharacterized protein	ISS	12181435	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00001	Adrenaline and noradrenaline biosynthesis	P00062	TH	CHICK|Ensembl=ENSGALG00000006551|UniProtKB=F6RRW6	Uncharacterized protein	ISS	12480184	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00038	JAK/STAT signaling pathway	P01027	STAT	MONDO|Ensembl=ENSMODG00000014836|UniProtKB=F7D2D3	Signal transducer and activator of transcription	ISS	95236292	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	CAEEL|WormBase=WBGene00001679|UniProtKB=P17343	Guanine nucleotide-binding protein subunit beta-1	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00010	B cell activation	P00376	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	91232861	PubMed	PTHR24070:SF385	GTPASE HRAS
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00220	c-Jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00012	Cadherin signaling pathway	P00470	F-actin	CAEEL|WormBase=WBGene00000200|UniProtKB=P53489	Actin-related protein 2	ISS	11889126	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P02761	Pantothenate biosynthesis	P03067	3-methyl-2-oxobutanoate hydroxymethyltransferase	AQUAE|EnsemblGenome=aq_1973|UniProtKB=O67783	3-methyl-2-oxobutanoate hydroxymethyltransferase	ISS			PTHR20881:SF0	3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE
P00029	Huntington disease	P00805	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00951	Jnk	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00006	Apoptosis signaling pathway	P00310	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	MACMU|Ensembl=ENSMMUG00000000135|UniProtKB=F7H624	Excitatory amino acid transporter 3	ISS	96032356	PubMed	PTHR11958:SF69	EXCITATORY AMINO ACID TRANSPORTER 3
P00034	Integrin signalling pathway	P00925	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MACMU|Ensembl=ENSMMUG00000004071|UniProtKB=F6ZJX4	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF141	TRANSFORMING GROWTH FACTOR BETA-2
P02730	Asparagine and aspartate biosynthesis	P02853	Asparagine synthetase	ECOLI|EcoGene=EG10092|UniProtKB=P22106	Asparagine synthetase B [glutamine-hydrolyzing]	ISS			PTHR11772:SF2	ASPARAGINE SYNTHETASE
P00013	Cell cycle	P00484	Cyclin D	BOVIN|Ensembl=ENSBTAG00000017514|UniProtKB=Q2KI22	G1/S-specific cyclin-D1	ISS	93330551	PubMed	PTHR10177:SF67	G1/S-SPECIFIC CYCLIN-D1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000008719|UniProtKB=F1MZX0	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00057	Wnt signaling pathway	P01435	SWI/SNF	CANLF|Ensembl=ENSCAFG00000008276|UniProtKB=E2R9I5	Uncharacterized protein	ISS	11532957	PubMed	PTHR10799:SF870	HELICASE-LIKE TRANSCRIPTION FACTOR
P00054	Toll receptor signaling pathway	P01357	MEKK1	PANTR|Ensembl=ENSPTRG00000016891|UniProtKB=H2R5K3	Uncharacterized protein	ISS	12049732	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00024	Glycolysis	P00679	Aldolase	MOUSE|MGI=MGI=1931052|UniProtKB=A6ZI47	Fructose-bisphosphate aldolase	ISS	6086339	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	IDA	8925912	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04398	p53 pathway feedback loops 2	G04715	CYCLIN G	RAT|RGD=2295|UniProtKB=P39950	Cyclin-G1	ISS	7957050	PubMed	PTHR10177:SF59	CYCLIN-G1
P00047	PDGF signaling pathway	P01168	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	XENTR|Ensembl=ENSXETG00000021375|UniProtKB=F6T423	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00059	p53 pathway	P04619	HMG1	RAT|Ensembl=ENSRNOG00000030351|UniProtKB=F1MA29	Uncharacterized protein	ISS			PTHR13711:SF164	HIGH MOBILITY GROUP PROTEIN B1-RELATED
P05918	p38 MAPK pathway	P06043	ASK1	MOUSE|MGI=MGI=1346876|UniProtKB=O35099	Mitogen-activated protein kinase kinase kinase 5	TAS	11730323	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P06587	Nicotine pharmacodynamics pathway	P06595	CHRNA3	RAT|RGD=2345|UniProtKB=P04757	Neuronal acetylcholine receptor subunit alpha-3	ISS	18005395	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MACMU|Ensembl=ENSMMUG00000009759|UniProtKB=F6ZIH3	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF504	MYOSIN-13
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00780	Microtubule	GIAIC|EnsemblGenome=GL50803_101291|UniProtKB=A8BEI6	Beta tubulin	IDA	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00052	TGF-beta signaling pathway	P01286	TGFbeta	DROME|FlyBase=FBgn0003719|UniProtKB=P25723	Dorsal-ventral patterning protein tolloid	TAS	9759503	PubMed	PTHR43978:SF2	DORSAL-VENTRAL PATTERNING PROTEIN TOLLOID-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00034	Integrin signalling pathway	P00951	Jnk	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	IDA	7600581	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	MOUSE|MGI=MGI=1351340|UniProtKB=Q9QYS2	Metabotropic glutamate receptor 3	ISS	9407094	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P02738	De novo purine biosynthesis	P02905	Amidophosphoribosyl transferase	ARATH|TAIR=AT4G38880|UniProtKB=Q9T0J5	Amidophosphoribosyltransferase 3, chloroplastic	ISS			PTHR11907:SF0	AMIDOPHOSPHORIBOSYLTRANSFERASE
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00006	Apoptosis signaling pathway	P00310	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01179	PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01150	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01098	CHT1	CANLF|Ensembl=ENSCAFG00000002064|UniProtKB=E2RAJ0	Uncharacterized protein	RCA			PTHR11819:SF129	HIGH AFFINITY CHOLINE TRANSPORTER 1
P00052	TGF-beta signaling pathway	P01275	P38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	TAS	12810719	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Ensembl=ENSPTRG00000000543|UniProtKB=H2PYN8	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00047	PDGF signaling pathway	P01163	c-Jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	MACMU|Ensembl=ENSMMUG00000009785|UniProtKB=F6Y1J3	C-C motif chemokine	ISS			PTHR12015:SF147	C-C MOTIF CHEMOKINE 13
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	STRCO|Gene=CAB82019|UniProtKB=Q9L0H7	Putative aldehyde dehydrogenase	IC			PTHR11699:SF202	SUBFAMILY NOT NAMED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_114535|UniProtKB=C3ZHN2	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00627	ERK1-2	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	DANRE|ZFIN=ZDB-GENE-990415-220|UniProtKB=Q9W6E3	Frizzled homolog 10	TAS	8717036	PubMed	PTHR11309:SF86	FRIZZLED-10
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	PANTR|Gene=DRD2|UniProtKB=P60026	D(2) dopamine receptor	ISS	2039532	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00018	EGF receptor signaling pathway	P00539	14-3-3	ORYSJ|EnsemblGenome=OS08G0480800|UniProtKB=Q84J55	14-3-3-like protein GF14-A	ISS	10407019	PubMed	PTHR18860:SF26	14-3-3 FAMILY PROTEIN-RELATED
P00021	FGF signaling pathway	P00648	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01153	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00053	T cell activation	P01320	PLC-gamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DROME|FlyBase=FBgn0000043|UniProtKB=P02572	Actin-42A	ISS	11889126	PubMed	PTHR11937:SF369	ACTIN-42A
P00019	Endothelin signaling pathway	P00570	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00020	FAS signaling pathway	P00616	Nuclear Lamin	HUMAN|HGNC=6636|UniProtKB=P02545	Prelamin-A/C	ISS	11165516	PubMed	PTHR23239:SF158	PRELAMIN-A/C
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	IDA	10556059	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	TAS	3045562	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8971|UniProtKB=O00443	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01286	TGFbeta	STRPU|EnsemblGenome=SPU_000668|UniProtKB=W4XBC1	Uncharacterized protein	TAS	9759503	PubMed	PTHR11848:SF176	LD29161P
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04395	Vasopressin synthesis	P04589	Signal Peptidase	DROME|FlyBase=FBgn0262801|UniProtKB=O97066	Signal peptidase complex catalytic subunit SEC11	IC	2674115	PubMed	PTHR10806:SF6	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00048	PI3 kinase pathway	P01179	PKB	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000024992|UniProtKB=F6TUR3	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00059	p53 pathway	P04630	PP2A	MOUSE|MGI=MGI=1321161|UniProtKB=P62715	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00627	ERK1-2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02738	De novo purine biosynthesis	P02905	Amidophosphoribosyl transferase	ECOLI|EcoGene=EG10794|UniProtKB=P0AG16	Amidophosphoribosyltransferase	ISS			PTHR11907:SF13	AMIDOPHOSPHORIBOSYLTRANSFERASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	PANTR|Ensembl=ENSPTRG00000011049|UniProtKB=H2QGF9	Glycogen synthase kinase 3 alpha	ISS	11995474	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P04393	Ras Pathway	P04556	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IDA	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02723	Adenine and hypoxanthine salvage pathway	P02807	Deoxyadenosine deaminase	STRCO|EnsemblGenome=CAA19890|UniProtKB=O86737	Aminodeoxyfutalosine deaminase	ISS			PTHR43114:SF3	SUBFAMILY NOT NAMED
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P02755	Methylmalonyl pathway	P03033	Propionyl-CoA carboxylase	HUMAN|HGNC=8653|UniProtKB=P05165	Propionyl-CoA carboxylase alpha chain, mitochondrial	ISS			PTHR18866:SF104	PROPIONYL-COA CARBOXYLASE ALPHA CHAIN, MITOCHONDRIAL
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	CHICK|Ensembl=ENSGALG00000016049|UniProtKB=F1P0T9	Uncharacterized protein	ISS			PTHR23409:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 B
P00010	B cell activation	P00375	Calmodulin	MONDO|Ensembl=ENSMODG00000004410|UniProtKB=F6SV58	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF322	SUBFAMILY NOT NAMED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00010	B cell activation	P00383	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P06959	CCKR signaling map	P07071	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	RCA	12829245	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00218	STAT1	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	14984365	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00021	FGF signaling pathway	P00648	PKC	SCHPO|PomBase=SPAC17G8.14c|UniProtKB=P36582	Protein kinase C-like 1	IGI	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	RCA	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00010	B cell activation	P00384	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00644	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00047	PDGF signaling pathway	P01173	STAT	HUMAN|HGNC=11366|UniProtKB=P42229	Signal transducer and activator of transcription 5A	ISS	8732682	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00023	General transcription regulation	P00658	TBP-associated factors	MOUSE|MGI=MGI=109129|UniProtKB=Q62311	Transcription initiation factor TFIID subunit 6	ISS			PTHR10221:SF12	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00029	Huntington disease	P00796	Kainate receptor	MOUSE|MGI=MGI=95818|UniProtKB=Q61626	Glutamate receptor ionotropic, kainate 5	IDA	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000023202|UniProtKB=F7EU36	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	RAT|RGD=67399|UniProtKB=Q64716	Insulin receptor-related protein	ISS	6754360	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P02731	Biotin biosynthesis	P02859	Dethiobiotin synthase	LEPIN|EnsemblGenome=LA_2141|UniProtKB=Q8F4A0	ATP-dependent dethiobiotin synthetase BioD	ISS			PTHR43210:SF2	DETHIOBIOTIN SYNTHETASE
P00025	Hedgehog signaling pathway	P00692	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00034	Integrin signalling pathway	P00925	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IDA	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	RAT|RGD=3381|UniProtKB=P62716	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00047	PDGF signaling pathway	P01142	p90RSK	BOVIN|Ensembl=ENSBTAG00000017639|UniProtKB=F1MZW8	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00006	Apoptosis signaling pathway	P00286	AIF	PANTR|Ensembl=ENSPTRG00000022265|UniProtKB=H2QZ39	Uncharacterized protein	ISS	9989411	PubMed	PTHR43557:SF4	APOPTOSIS-INDUCING FACTOR 1, MITOCHONDRIAL
P00048	PI3 kinase pathway	P01181	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	ARATH|TAIR=AT4G20320|UniProtKB=Q0WRY1	CTP synthase	ISS			PTHR11550:SF23	CTP SYNTHASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_115566|UniProtKB=C3XYC8	Putative uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	IGI	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CHICK|Ensembl=ENSGALG00000027629|UniProtKB=Q5ZJ03	Guanine nucleotide-binding protein subunit gamma	IC	11313908	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00005	Angiogenesis	P00203	Erk	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	BOVIN|Ensembl=ENSBTAG00000006877|UniProtKB=F1N797	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF26	MATRIX METALLOPROTEINASE-16
P00012	Cadherin signaling pathway	P00470	F-actin	DANRE|ZFIN=ZDB-GENE-030131-1229|UniProtKB=Q6DHS1	Actin, alpha 2, smooth muscle, aorta	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MOUSE|MGI=MGI=95779|UniProtKB=P50149	Guanine nucleotide-binding protein G(t) subunit alpha-2	ISS	12488551	PubMed	PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P00017	DNA replication	P00530	Top	PANTR|Ensembl=ENSPTRG00000009122|UniProtKB=H2QCW5	DNA topoisomerase 2	RCA			PTHR10169:SF46	DNA TOPOISOMERASE 2-ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00018	EGF receptor signaling pathway	P00547	PP2A	XENTR|Xenbase=XB-GENE-957526|UniProtKB=K9J7P6	Uncharacterized protein	ISS	11007767	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	SCHPO|PomBase=SPAC22E12.09c|UniProtKB=Q09175	Dibasic-processing endoprotease	IDA	10956649	PubMed	PTHR42884:SF14	NEUROENDOCRINE CONVERTASE 1
P04398	p53 pathway feedback loops 2	P04657	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CHICK|Ensembl=ENSGALG00000015434|UniProtKB=F1NU20	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00047	PDGF signaling pathway	P01174	Rho	CAEBR|Gene=CBG06126|UniProtKB=A8X0U6	Protein CBR-SRGP-1	ISS			PTHR14166:SF17	SLIT-ROBO GAP HOMOLOG
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	DICDI|dictyBase=DDB_G0272616|UniProtKB=P42521	Ribonucleoside-diphosphate reductase small subunit	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00045	Notch signaling pathway	G01541	E(spl)-C genes	PANTR|Ensembl=ENSPTRG00000000085|UniProtKB=H2PXW9	Uncharacterized protein	ISS			PTHR10985:SF15	TRANSCRIPTION FACTOR HES-2
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	PANTR|Ensembl=ENSPTRG00000005015|UniProtKB=H2Q624	Anti-Muellerian hormone type-2 receptor	ISS	9759503	PubMed	PTHR23255:SF49	ANTI-MUELLERIAN HORMONE TYPE-2 RECEPTOR
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00025	Hedgehog signaling pathway	P00692	GSK3	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000009766|UniProtKB=F6TFL4	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00018	EGF receptor signaling pathway	P00547	PP2A	PANTR|Ensembl=ENSPTRG00000003853|UniProtKB=H2Q411	Protein phosphatase 2, regulatory subunit B', beta	ISS	96161994	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P00053	T cell activation	P01322	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000022174|UniProtKB=F6XHZ4	Uncharacterized protein	ISS			PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00053	T cell activation	P01324	rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00034	Integrin signalling pathway	P00936	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04393	Ras Pathway	P04568	MKK3/6	HUMAN|HGNC=6843|UniProtKB=P46734	Dual specificity mitogen-activated protein kinase kinase 3	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=11330|UniProtKB=P30872	Somatostatin receptor type 1	IDA	12562507	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MACMU|Ensembl=ENSMMUG00000016256|UniProtKB=F7GM91	Uncharacterized protein	ISS	22028976	PubMed	PTHR13140:SF311	MYOSIN-IIIB
P00048	PI3 kinase pathway	P01202	p85	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00057	Wnt signaling pathway	P01444	Wnt	DROME|FlyBase=FBgn0010194|UniProtKB=P28466	Protein Wnt-5	IDA	8717036	PubMed	PTHR12027:SF77	PROTEIN WNT-5
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	DICDI|dictyBase=DDB_G0272110|UniProtKB=P51136	Glycogen synthase kinase-3	IDA	21361340	gi	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	IDA	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00021	FGF signaling pathway	P00645	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01428	Frizzled	MOUSE|MGI=MGI=108520|UniProtKB=Q61088	Frizzled-4	IDA	8717036	PubMed	PTHR11309:SF23	FRIZZLED-4
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CAEEL|WormBase=WBGene00002189|UniProtKB=P21137	cAMP-dependent protein kinase catalytic subunit	IC	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-961282|UniProtKB=Q6DF43	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00049	Parkinson disease	P01242	Casein kinase I	BOVIN|Ensembl=ENSBTAG00000005326|UniProtKB=P67827	Casein kinase I isoform alpha	ISS	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00006	Apoptosis signaling pathway	P00299	Caspase 8	HUMAN|HGNC=1509|UniProtKB=Q14790	Caspase-8	ISS	11788820	PubMed	PTHR10454:SF162	CASPASE-8
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P06664	Gonadotropin-releasing hormone receptor pathway	G06895	mPer1	MOUSE|MGI=MGI=1098283|UniProtKB=O35973	Period circadian protein homolog 1	RCA	12782655	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MOUSE|MGI=MGI=102705|UniProtKB=P63213	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00057	Wnt signaling pathway	P01465	Ggamma	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	CANLF|Ensembl=ENSCAFG00000015662|UniProtKB=E2RHY4	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00047	PDGF signaling pathway	P01161	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02746	Heme biosynthesis	P02976	Protoporphyrinogen oxidase	MACMU|Ensembl=ENSMMUG00000022630|UniProtKB=F6Z0I4	Uncharacterized protein	ISS			PTHR42923:SF3	PROTOPORPHYRINOGEN OXIDASE
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95811|UniProtKB=Q9Z2W8	Glutamate receptor 4	ISS	12497607	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04393	Ras Pathway	P04567	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	STRPU|EnsemblGenome=SPU_018419|UniProtKB=W4YRI6	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00558	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IGI	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02776	Serine glycine biosynthesis	P03160	Phosphoglycerate dehydrogenase	ANOGA|EnsemblGenome=AGAP008849|UniProtKB=Q7PWU4	AGAP008849-PA	ISS			PTHR42938:SF5	D-3-PHOSPHOGLYCERATE DEHYDROGENASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	XENTR|Xenbase=XB-GENE-6469705|UniProtKB=Q6P8G3	Actin, alpha sarcomeric/skeletal	ISS	14684598	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	MACMU|Ensembl=ENSMMUG00000015828|UniProtKB=F7CE90	Recombining binding protein suppressor of hairless isoform 4	ISS	12145413	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01440	Cadherin	BOVIN|Ensembl=ENSBTAG00000017349|UniProtKB=A5D7F4	PCDHGC3 protein	ISS	8120095	PubMed	PTHR24028:SF70	PROTOCADHERIN GAMMA-C3
P02778	Sulfate assimilation	P03167	Sulfate adenylyltransferase	CANLF|Ensembl=ENSCAFG00000015654|UniProtKB=E2R1E3	Uncharacterized protein	ISS			PTHR11055:SF16	BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00047	PDGF signaling pathway	P01154	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00310	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IDA	14526383	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00055	Transcription regulation by bZIP transcription factor	P01395	TFIIE	MACMU|Ensembl=ENSMMUG00000001596|UniProtKB=F7GV34	General transcription factor IIE subunit 1	ISS	189962	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00050	Plasminogen activating cascade	P01263	pro-MMP-1	HUMAN|HGNC=7155|UniProtKB=P03956	Interstitial collagenase	IGI	3009463	PubMed	PTHR10201:SF151	INTERSTITIAL COLLAGENASE
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	CHICK|Ensembl=ENSGALG00000014033|UniProtKB=E1BTS2	Uncharacterized protein	ISS	3023884	PubMed	PTHR24070:SF186	GTPASE KRAS
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P05917	Opioid proopiomelanocortin pathway	P06009	K+ channel	HUMAN|HGNC=6278|UniProtKB=O14649	Potassium channel subfamily K member 3	ISS	15282272	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000013316|UniProtKB=H2QK23	Uncharacterized protein	ISS	12441358	PubMed	PTHR24229:SF52	SOMATOSTATIN RECEPTOR TYPE 4
P00048	PI3 kinase pathway	P01199	Galpha	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS			PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00046	Oxidative stress response	P01138	MKK4	CANLF|Ensembl=ENSCAFG00000017851|UniProtKB=F1PBB6	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PRIPA|Gene=PPA02893|UniProtKB=H3DZP2	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF120	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00623	FGF	RAT|RGD=2610|UniProtKB=P36364	Fibroblast growth factor 9	ISS			PTHR11486:SF28	FIBROBLAST GROWTH FACTOR 9
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	PANTR|Ensembl=ENSPTRG00000018361|UniProtKB=P60020	5-hydroxytryptamine receptor 1B	ISS			PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	TAS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	HUMAN|HGNC=7882|UniProtKB=Q04721	Neurogenic locus notch homolog protein 2	IDA	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00049	Parkinson disease	P01208	Hsp70	MOUSE|MGI=MGI=96231|UniProtKB=P16627	Heat shock 70 kDa protein 1-like	IDA	12150907	PubMed	PTHR19375:SF210	HEAT SHOCK 70 KDA PROTEIN 1-LIKE
P00009	Axon guidance mediated by netrin	P00363	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05964	GNAZ	MONDO|Ensembl=ENSMODG00000010036|UniProtKB=F6TUG0	Uncharacterized protein	ISS	16814816	PubMed	PTHR10218:SF65	GUANINE NUCLEOTIDE-BINDING PROTEIN G Z  SUBUNIT ALPHA
P04393	Ras Pathway	P04566	Stat 1/3	MACMU|Ensembl=ENSMMUG00000010707|UniProtKB=F7G8G5	Signal transducer and activator of transcription	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00049	Parkinson disease	P01235	Fyn kinase	TAKRU|Ensembl=ENSTRUG00000003538|UniProtKB=H2S7D1	Tyrosine-protein kinase	ISS	9741627	PubMed	PTHR24418:SF242	TYROSINE-PROTEIN KINASE FYNB
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MOUSE|MGI=MGI=1351345|UniProtKB=P47743	Metabotropic glutamate receptor 8	IDA			PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	RCA	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00012	Cadherin signaling pathway	P00470	F-actin	STRPU|Gene=CYIIIA|UniProtKB=P53474	Actin, cytoskeletal 3A	IC	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000000843|UniProtKB=H2QZN8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00021	FGF signaling pathway	P00634	MEKK1-5	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P02744	Fructose galactose metabolism	P02964	Hexose 1-P uridyltransferase	CRYNJ|EnsemblGenome=CNM00620|UniProtKB=P0CN76	Galactose-1-phosphate uridylyltransferase	ISS	8577246	PubMed	PTHR11943:SF2	GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05918	p38 MAPK pathway	P06023	MEF	MOUSE|MGI=MGI=99458|UniProtKB=Q8CFN5	Myocyte-specific enhancer factor 2C	RCA	11274345	PubMed	PTHR11945:SF25	MYOCYTE-SPECIFIC ENHANCER FACTOR 2C
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05923	beta-ARR2	BOVIN|Gene=ARRB2|UniProtKB=P32120	Beta-arrestin-2	RCA	9388255	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000022319|UniProtKB=F6XDA0	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=107709|UniProtKB=Q99MZ6	Unconventional myosin-VIIb	IC			PTHR13140:SF505	UNCONVENTIONAL MYOSIN-VIIB
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	HUMAN|HGNC=7883|UniProtKB=Q9UM47	Neurogenic locus notch homolog protein 3	IDA	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00021	FGF signaling pathway	P00624	14-3-3	DROME|FlyBase=FBgn0020238|UniProtKB=P92177	14-3-3 protein epsilon	IGI	97302963	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00056	VEGF signaling pathway	P01407	Erk	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	PANTR|Gene=CHRM5|UniProtKB=Q5IS53	Muscarinic acetylcholine receptor M5	ISS	8100450	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00005	Angiogenesis	P00212	EphR	CANLF|Ensembl=ENSCAFG00000013005|UniProtKB=F1P9P1	Uncharacterized protein	ISS	9990854	PubMed	PTHR24416:SF120	EPHRIN TYPE-B RECEPTOR 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CHICK|Ensembl=ENSGALG00000009621|UniProtKB=P60706	Actin, cytoplasmic 1	ISS	11889139	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00046	Oxidative stress response	P01135	p38	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	ANOGA|EnsemblGenome=AGAP006718|UniProtKB=Q7QI86	AGAP006718-PA	ISS	96032356	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	PANTR|Ensembl=ENSPTRG00000012613|UniProtKB=H2QIY0	Uncharacterized protein	ISS	11907044	PubMed	PTHR44025:SF5	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	MOUSE|MGI=MGI=104781|UniProtKB=P48542	G protein-activated inward rectifier potassium channel 2	ISS	2433589	PubMed	PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=1352756|UniProtKB=Q8K394	Inactive phospholipase C-like protein 2	ISS			PTHR10336:SF84	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2
P06217	Toll pathway-drosophila	P06338	PLL	DROME|FlyBase=FBgn0010441|UniProtKB=Q05652	Serine/threonine-protein kinase pelle	IGI	8440018	PubMed	PTHR24419:SF33	SERINE/THREONINE-PROTEIN KINASE PELLE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00049	Parkinson disease	P01211	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	CHICK|Gene=T|UniProtKB=P79777	Brachyury protein	IEP	12356903	PubMed	PTHR11267:SF83	BRACHYURY PROTEIN
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=1921305|UniProtKB=Q8K4S1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	12176394	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00053	T cell activation	P01335	jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00045	Notch signaling pathway	P01103	Next	BOVIN|Ensembl=ENSBTAG00000007909|UniProtKB=F1MPE9	Uncharacterized protein	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00046	Oxidative stress response	P01135	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00004	Alzheimer disease-presenilin pathway	P00127	APP	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00018	EGF receptor signaling pathway	P00542	EGFR	MOUSE|MGI=MGI=95410|UniProtKB=P70424	Receptor tyrosine-protein kinase erbB-2	ISS	8393325	gi	PTHR24416:SF137	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2
P00047	PDGF signaling pathway	P01164	PDK1/2	ARATH|TAIR=AT5G04510|UniProtKB=Q9XF67	3-phosphoinositide-dependent protein kinase 1	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05970	TH	MOUSE|MGI=MGI=98735|UniProtKB=P24529	Tyrosine 3-monooxygenase	ISS	191290	OMIM	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00006	Apoptosis signaling pathway	P00321	HSP70	ARATH|TAIR=AT5G28540|UniProtKB=Q9LKR3	Mediator of RNA polymerase II transcription subunit 37a	ISS	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00021	FGF signaling pathway	P00634	MEKK1-5	HUMAN|HGNC=6857|UniProtKB=Q99683	Mitogen-activated protein kinase kinase kinase 5	IGI	12566458	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	MACMU|Ensembl=ENSMMUG00000013797|UniProtKB=F6TDC4	Uncharacterized protein	ISS			PTHR10937:SF2	GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE  ISOMERIZING  1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	HUMAN|HGNC=12372|UniProtKB=P01222	Thyrotropin subunit beta	ISS	5101174	PubMed	PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TAKRU|Ensembl=ENSTRUG00000014318|UniProtKB=H2UI49	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	HUMAN|HGNC=784|UniProtKB=P15336	Cyclic AMP-dependent transcription factor ATF-2	TAS	10664585	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	CANLF|Ensembl=ENSCAFG00000004882|UniProtKB=F1PAE3	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	NEUCR|Gene=NCU04856|UniProtKB=V5ILU9	Glutamine synthetase	ISS			PTHR20852:SF57	GLUTAMINE SYNTHETASE 2 CYTOPLASMIC
P02728	Arginine biosynthesis	P02840	Argininosuccinate synthase	MOUSE|MGI=MGI=88090|UniProtKB=P16460	Argininosuccinate synthase	ISS			PTHR11587:SF2	ARGININOSUCCINATE SYNTHASE
P00053	T cell activation	P01306	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	3035212	PubMed	PTHR24070:SF385	GTPASE HRAS
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	HUMAN|HGNC=9235|UniProtKB=Q03181	Peroxisome proliferator-activated receptor delta	IEP	12356903	PubMed	PTHR24082:SF15	PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DELTA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	ISS	94280860	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P02744	Fructose galactose metabolism	P02960	Galactokinase	MOUSE|MGI=MGI=95730|UniProtKB=Q9R0N0	Galactokinase	NAS	12003984	gi	PTHR10457:SF6	GALACTOKINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	HUMAN|HGNC=9299|UniProtKB=P67775	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00052	TGF-beta signaling pathway	P01275	P38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	TAS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00005	Angiogenesis	P00211	GSK3beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05913	Enkephalin release	P05973	GPCR (i)	HUMAN|HGNC=8153|UniProtKB=P41143	Delta-type opioid receptor	ISS	11259498	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00018	EGF receptor signaling pathway	P00542	EGFR	HUMAN|HGNC=3432|UniProtKB=Q15303	Receptor tyrosine-protein kinase erbB-4	IGI	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00054	Toll receptor signaling pathway	P01360	IKKbeta	RAT|RGD=621375|UniProtKB=Q9QY78	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-486685|UniProtKB=F6VT32	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00059	p53 pathway	P04630	PP2A	HUMAN|HGNC=9300|UniProtKB=P62714	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00810	GAPDH	BACSU|EnsemblGenome=BSU29020|UniProtKB=O34425	Glyceraldehyde-3-phosphate dehydrogenase 2	IPI			PTHR43148:SF4	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01012	PICK	HUMAN|HGNC=9394|UniProtKB=Q9NRD5	PRKCA-binding protein	ISS	12941441	PubMed	PTHR12141:SF1	PRKCA-BINDING PROTEIN
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00020	FAS signaling pathway	P00616	Nuclear Lamin	PANTR|Ensembl=ENSPTRG00000017188|UniProtKB=H2QRE7	Lamin B1	ISS	11165516	PubMed	PTHR23239:SF157	LAMIN-B1
P04393	Ras Pathway	P04557	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	IDA	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00059	p53 pathway	P01486	Akt	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	TAS	9716402	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01230	Src kinase	CANLF|Ensembl=ENSCAFG00000008755|UniProtKB=E2RSH8	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00053	T cell activation	P01311	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IDA	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00183	Shc	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	IDA	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00021	FGF signaling pathway	P00629	PP2A	IXOSC|EnsemblGenome=ISCW015013|UniProtKB=B7QHS1	Serine/threonine-protein phosphatase	ISS			PTHR11668:SF22	SERINE/THREONINE-PROTEIN PHOSPHATASE 4 CATALYTIC SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	DROME|FlyBase=FBgn0260964|UniProtKB=Q8IH57	GH10249p	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BOVIN|Ensembl=ENSBTAG00000018020|UniProtKB=P04695	Guanine nucleotide-binding protein G(t) subunit alpha-1	ISS	6264430	PubMed	PTHR10218:SF67	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-1
P00036	Interleukin signaling pathway	P00976	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00057	Wnt signaling pathway	P01438	PP2A	DROME|FlyBase=FBgn0027492|UniProtKB=Q9VB23	BcDNA.LD34343	IDA			PTHR10257:SF29	BCDNA.LD34343
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	CHICK|Ensembl=ENSGALG00000028896|UniProtKB=R4GMK5	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF728	MYOSIN HEAVY CHAIN, SKELETAL MUSCLE, ADULT
P00034	Integrin signalling pathway	P00922	Collagen	PANTR|Ensembl=ENSPTRG00000000464|UniProtKB=H2PYJ3	Uncharacterized protein	ISS	10778855	PubMed	PTHR24023:SF372	COLLAGEN ALPHA-1 XVI  CHAIN
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	227170	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000012820|UniProtKB=F1MDL3	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DANRE|ZFIN=ZDB-GENE-041210-195|UniProtKB=F1R506	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00048	PI3 kinase pathway	P01199	Galpha	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS			PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	ANOGA|EnsemblGenome=AGAP005913|UniProtKB=Q7Q6D2	AGAP005913-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	CHICK|Ensembl=ENSGALG00000011558|UniProtKB=F1NWV6	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00029	Huntington disease	P00790	beta-Tubulin	LEIMA|EnsemblGenome=LmjF.08.1230|UniProtKB=Q4QI42	Beta tubulin	TAS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04395	Vasopressin synthesis	P04594	Neurophysin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00020	FAS signaling pathway	P00594	Caspase8	MACMU|Ensembl=ENSMMUG00000012310|UniProtKB=F7DL95	CASP8 and FADD-like apoptosis regulator isoform 1	ISS	8681376	PubMed	PTHR10454:SF8	CASP8 AND FADD-LIKE APOPTOSIS REGULATOR
P00007	Axon guidance mediated by semaphorins	P00340	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12874273	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00019	Endothelin signaling pathway	P00570	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00035	Interferon-gamma signaling pathway	P00956	SOCS	MOUSE|MGI=MGI=2385459|UniProtKB=O54928	Suppressor of cytokine signaling 5	TAS	15032587	PubMed	PTHR44282:SF3	SUPPRESSOR OF CYTOKINE SIGNALING 5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	CANLF|Ensembl=ENSCAFG00000019608|UniProtKB=E2R7K4	Uncharacterized protein	ISS	10391901	PubMed	PTHR15936:SF2	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-13
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00019	Endothelin signaling pathway	P00589	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	IGI	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01093	AChE	BRAFL|Gene=BRAFLDRAFT_132597|UniProtKB=C3ZRW7	Carboxylic ester hydrolase	ISS	87080761	PubMed	PTHR11559:SF356	ACETYLCHOLINESTERASE
P00012	Cadherin signaling pathway	P00470	F-actin	ARATH|TAIR=AT3G18780|UniProtKB=Q96292	Actin-2	IC	14684598	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00004	Alzheimer disease-presenilin pathway	P00163	Erb-B4 C-terminal fragment	RAT|RGD=620486|UniProtKB=Q62956	Receptor tyrosine-protein kinase erbB-4	IDA	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P05912	Dopamine receptor mediated signaling pathway	P05951	CDK5	TAKRU|Ensembl=ENSTRUG00000004034|UniProtKB=H2SAY8	Uncharacterized protein	ISS	10604473,	PubMed	PTHR24056:SF46	CYCLIN-DEPENDENT-LIKE KINASE 5
P00029	Huntington disease	P00766	Htt	HUMAN|HGNC=4851|UniProtKB=P42858	Huntingtin	IDA	7620118	PubMed	PTHR10170:SF10	HUNTINGTIN
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00551	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IGI	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01161	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00227	PLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00030	Hypoxia response via HIF activation	P00819	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	PANTR|Ensembl=ENSPTRG00000013902|UniProtKB=H2RCL0	Uncharacterized protein	ISS	2433589	PubMed	PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P00048	PI3 kinase pathway	P01177	P110ACT	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	IC	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00052	TGF-beta signaling pathway	P01288	FKBP12	ANOGA|EnsemblGenome=AGAP012184|UniProtKB=Q7PVA5	Peptidyl-prolyl cis-trans isomerase	ISS			PTHR10516:SF341	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE
P00021	FGF signaling pathway	P00629	PP2A	DICPU|Gene=DICPUDRAFT_91511|UniProtKB=F0ZDJ1	Serine/threonine-protein phosphatase	ISS	10452519	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IGI	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00912	Arp2/3	MOUSE|MGI=MGI=1923959|UniProtKB=Q9CVB6	Actin-related protein 2/3 complex subunit 2	ISS	17943202	gi	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P02763	Peptidoglycan biosynthesis	P03091	D-alanine-D-alanine ligase	ECOLI|EcoGene=EG10214|UniProtKB=P07862	D-alanine--D-alanine ligase B	ISS			PTHR23132:SF12	D-ALANINE--D-ALANINE LIGASE B
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	CAEEL|WormBase=WBGene00001622|UniProtKB=Q22682	Putative sodium-dependent excitatory amino acid transporter glt-4	ISS	94365697	PubMed	PTHR11958:SF56	SODIUM-DEPENDENT EXCITATORY AMINO ACID TRANSPORTER GLT-4-RELATED
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	BOVIN|Ensembl=ENSBTAG00000017514|UniProtKB=Q2KI22	G1/S-specific cyclin-D1	ISS	93330551	PubMed	PTHR10177:SF67	G1/S-SPECIFIC CYCLIN-D1
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00644	p38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P02781	Threonine biosynthesis	P03192	Aspartate semialdehyde dehydrogenase	BACTN|EnsemblGenome=BT_3636|UniProtKB=Q8A1M5	Aspartate-semialdehyde dehydrogenase	ISS			PTHR10174:SF2	ASPARTATE-SEMIALDEHYDE DEHYDROGENASE
P02743	Formyltetrahydroformate biosynthesis	P02952	Methylene tetrahydrofolate dehydrogenase	ARATH|TAIR=AT2G38660|UniProtKB=A2RVV7	Bifunctional protein FolD 1, mitochondrial	ISS			PTHR10025:SF56	10-FORMYLTETRAHYDROFOLATE SYNTHETASE-RELATED
P06959	CCKR signaling map	P07098	p46 SHC1	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	RCA	9230117	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00034	Integrin signalling pathway	P00925	MEK	HUMAN|HGNC=6844|UniProtKB=P45985	Dual specificity mitogen-activated protein kinase kinase 4	IDA	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00034	Integrin signalling pathway	P00931	Integrin beta	BOVIN|Ensembl=ENSBTAG00000015910|UniProtKB=P53712	Integrin beta-1	IDA	3487386	PubMed	PTHR10082:SF28	INTEGRIN BETA-1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	ECOLI|EcoGene=EG12381|UniProtKB=P37146	Ribonucleoside-diphosphate reductase 2 subunit beta	ISS			PTHR23409:SF32	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT BETA
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	RCA	91298951	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00057	Wnt signaling pathway	P01447	Dishevelled	HUMAN|HGNC=3087|UniProtKB=Q92997	Segment polarity protein dishevelled homolog DVL-3	ISS	10409711	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P02751	Lysine biosynthesis	P03008	Dihydrodipicolinate synthase	PSEAE|EnsemblGenome=PA1010|UniProtKB=Q9I4W3	4-hydroxy-tetrahydrodipicolinate synthase	ISS			PTHR12128:SF15	4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00049	Parkinson disease	P01212	p38 MAPK	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	NAS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	HUMAN|HGNC=4214|UniProtKB=P27539	Embryonic growth/differentiation factor 1	TAS	10844590	PubMed	PTHR11848:SF151	EMBRYONIC GROWTH/DIFFERENTIATION FACTOR 1
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00048	PI3 kinase pathway	P01192	p110	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00912	Arp2/3	ORNAN|Ensembl=ENSOANG00000000999|UniProtKB=F6WN02	Actin-related protein 2/3 complex subunit 5	ISS	12932731	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00029	Huntington disease	P00780	Microtubule	STRPU|EnsemblGenome=SPU_016007|UniProtKB=W4YJP3	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00059	p53 pathway	P04615	MTA2	XENTR|Xenbase=XB-GENE-947630|UniProtKB=F6YU32	Uncharacterized protein	ISS			PTHR10865:SF4	METASTASIS-ASSOCIATED PROTEIN MTA2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	RAT|RGD=2343|UniProtKB=P08483	Muscarinic acetylcholine receptor M3	IDA	12181435	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P02780	Thiamin metabolism	P03176	Thiamine kinase	HUMAN|HGNC=17358|UniProtKB=Q9H3S4	Thiamin pyrophosphokinase 1	RCA			PTHR13622:SF8	THIAMIN PYROPHOSPHOKINASE 1
P00048	PI3 kinase pathway	P01199	Galpha	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00748	Gbeta5L	HUMAN|HGNC=4401|UniProtKB=O14775	Guanine nucleotide-binding protein subunit beta-5	IDA	11313908	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00029	Huntington disease	P00775	Rac	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	IDA	12169092	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CANLF|Ensembl=ENSCAFG00000009203|UniProtKB=F1PVZ1	Muscarinic acetylcholine receptor	ISS			PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00021	FGF signaling pathway	P00632	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04384	Gamma-aminobutyric acid synthesis	P04480	GABA aminotransferase	NEUCR|Gene=NCU08998|UniProtKB=U9W589	4-aminobutyrate aminotransferase	ISS	8133261	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P02723	Adenine and hypoxanthine salvage pathway	P02811	Adenosine deaminase	SCHPO|PomBase=SPBC1198.02|UniProtKB=Q9P6I7	Adenine deaminase	ISS			PTHR43114:SF2	ADENINE DEAMINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ARATH|TAIR=AT2G42090|UniProtKB=P93738	Putative actin-9	IC	10974003	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=12775|UniProtKB=O00744	Protein Wnt-10b	TAS	8717036	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	TAS	3755548	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05938	RhoA	XENTR|Xenbase=XB-GENE-489222|UniProtKB=Q28GJ8	Ras homolog gene family, member A	ISS	11360179	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	PANTR|Ensembl=ENSPTRG00000012999|UniProtKB=H2R2S1	C-C motif chemokine	ISS	12067311	PubMed	PTHR12015:SF108	C-C MOTIF CHEMOKINE 20
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS			PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00004	Alzheimer disease-presenilin pathway	P00111	C99	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00047	PDGF signaling pathway	P01154	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00037	Ionotropic glutamate receptor pathway	P01026	KA	ORNAN|Ensembl=ENSOANG00000002061|UniProtKB=F7ANC6	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P04395	Vasopressin synthesis	P04593	Glycopeptide	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	RCA	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01315	Calcineurin	HUMAN|HGNC=9316|UniProtKB=P48454	Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform	IGI	12015605	PubMed	PTHR11668:SF186	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT GAMMA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00004	Alzheimer disease-presenilin pathway	P00178	BACE-1 pro-domain	HUMAN|HGNC=933|UniProtKB=P56817	Beta-secretase 1	IDA	10956649	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00010	B cell activation	P00367	NFAT	PANTR|Ensembl=ENSPTRG00000008260|UniProtKB=H2QBD7	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	ISS	12015605	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	RCA	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IDA	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00010	B cell activation	P00383	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00056	VEGF signaling pathway	P01407	Erk	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00059	p53 pathway	P04609	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00775	Rac	CHICK|Ensembl=ENSGALG00000002859|UniProtKB=F6UBD2	Uncharacterized protein	ISS	15470041	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	BOVIN|Ensembl=ENSBTAG00000012687|UniProtKB=F1MV64	Tyrosine-protein kinase receptor	ISS	2983222	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P00045	Notch signaling pathway	P01103	Next	HUMAN|HGNC=6188|UniProtKB=P78504	Protein jagged-1	IGI	1286675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P04395	Vasopressin synthesis	P04596	Endo Peptidase	ARATH|TAIR=AT1G50380|UniProtKB=Q9SX53	At1g50380/F14I3_27	IC			PTHR11757:SF3	PROTEASE 2
P06664	Gonadotropin-releasing hormone receptor pathway	P06701	TCF	MOUSE|MGI=MGI=98507|UniProtKB=Q00417	Transcription factor 7	RCA			PTHR10373:SF33	TRANSCRIPTION FACTOR 7
P02738	De novo purine biosynthesis	P02908	Phosphoribosylamine glycine ligase	PYRAE|EnsemblGenome=PAE0216|UniProtKB=Q8ZZK4	Phosphoribosylamine--glycine ligase	ISS			PTHR43472:SF1	PHOSPHORIBOSYLAMINE--GLYCINE LIGASE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00006	Apoptosis signaling pathway	P00260	AKT	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00560	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00916	Ras	DANRE|ZFIN=ZDB-GENE-990415-166|UniProtKB=P79737	GTPase NRas	IPI	9116869	PubMed	PTHR24070:SF189	GTPASE NRAS
P00059	p53 pathway	G01579	PTEN	XENTR|Xenbase=XB-GENE-491433|UniProtKB=B1H2U0	Pten protein	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04397	p53 pathway by glucose deprivation	P04640	p53	CANLF|Ensembl=ENSCAFG00000013961|UniProtKB=F1PL57	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00012	Cadherin signaling pathway	P00470	F-actin	USTMA|Gene=UMAG_11232|UniProtKB=A0A0D1DMT3	Chromosome 22, whole genome shotgun sequence	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00018	EGF receptor signaling pathway	P00564	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12676940	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00237	FRP	PANTR|Ensembl=ENSPTRG00000020122|UniProtKB=H2QVZ0	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF22	FRIZZLED-3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000002016|UniProtKB=F1P3G1	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00018	EGF receptor signaling pathway	P00562	p38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IGI	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00018	EGF receptor signaling pathway	P00562	p38	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	8920915	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	RAT|RGD=619735|UniProtKB=P62916	Transcription initiation factor IIB	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P04384	Gamma-aminobutyric acid synthesis	P04480	GABA aminotransferase	BOVIN|Gene=ABAT|UniProtKB=Q9BGI0	4-aminobutyrate aminotransferase, mitochondrial	ISS	2496985	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00056	VEGF signaling pathway	P01417	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04559	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	PANTR|Ensembl=ENSPTRG00000001477|UniProtKB=H2Q0A5	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	6264430	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00054	Toll receptor signaling pathway	P01375	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00807	Actin	DICDI|dictyBase=DDB_G0275023|UniProtKB=Q553U6	Putative actin-22	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00562	p38	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	IGI	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05915	Opioid proenkephalin pathway	P05994	G-protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	1482697	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	TAS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00034	Integrin signalling pathway	P00941	Integrin alpha	XENTR|Xenbase=XB-GENE-493953|UniProtKB=F6YFL0	Uncharacterized protein	ISS	3487386	PubMed	PTHR23220:SF3	INTEGRIN ALPHA-5
P02757	O-antigen biosynthesis	P03050	dTDP-4-dehydrorhamnose reductase	SULSO|EnsemblGenome=SSO1783|UniProtKB=Q97XF9	dTDP-4-dehydrorhamnose reductase (RfbD-2)	ISS			PTHR43242:SF1	NAD P -BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN
P00005	Angiogenesis	P00234	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P05730	Endogenous cannabinoid signaling	P05751	Galpha	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P02738	De novo purine biosynthesis	P02902	ADP reductase	BACSU|EnsemblGenome=BSU20060|UniProtKB=O31875	Ribonucleoside-diphosphate reductase NrdEB subunit alpha	ISS			PTHR11573:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05913	Enkephalin release	G06046	preproenkephalin mRNA	MACMU|Ensembl=ENSMMUG00000006775|UniProtKB=F7H3N8	Uncharacterized protein	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	TAS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00046	Oxidative stress response	P01127	eEF2K	MOUSE|MGI=MGI=1195261|UniProtKB=O08796	Eukaryotic elongation factor 2 kinase	TAS	11500363	PubMed	PTHR14187:SF56	EUKARYOTIC ELONGATION FACTOR 2 KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	RCA	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00021	FGF signaling pathway	P00648	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04398	p53 pathway feedback loops 2	P04658	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PANTR|Ensembl=ENSPTRG00000009762|UniProtKB=H2QE24	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	CANLF|Ensembl=ENSCAFG00000023650|UniProtKB=E2QWU0	Actin-related protein 2/3 complex subunit 4	ISS	9230079	PubMed	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347742|UniProtKB=E9FZ00	Cytoplasmatic actin	ISS	11889126	PubMed	PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P02738	De novo purine biosynthesis	P02909	GDP reductase	SCHPO|PomBase=SPAC1F7.05|UniProtKB=P36602	Ribonucleoside-diphosphate reductase large chain	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04573	Elk-1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	IDA	10487205	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	HUMAN|HGNC=1401|UniProtKB=Q02641	Voltage-dependent L-type calcium channel subunit beta-1	IC	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00015	Circadian clock system	P00501	Clock	XENTR|Xenbase=XB-GENE-495448|UniProtKB=F6ZYJ9	Uncharacterized protein (Fragment)	ISS			PTHR23042:SF2	CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT
P00005	Angiogenesis	P00200	Dsh	PANTR|Ensembl=ENSPTRG00000015681|UniProtKB=H2QNU7	Dishevelled, dsh homolog 3	ISS	11212302	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P04393	Ras Pathway	P04556	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IDA	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MACMU|Ensembl=ENSMMUG00000001661|UniProtKB=F7GR69	Uncharacterized protein	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00034	Integrin signalling pathway	P00948	Rho	SCHPO|PomBase=SPAC1F7.04|UniProtKB=Q09914	GTP-binding protein rho1	IGI	11973360	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00055	Transcription regulation by bZIP transcription factor	P01395	TFIIE	PANTR|Ensembl=ENSPTRG00000022529|UniProtKB=H2QZJ1	Transcription initiation factor IIE subunit beta	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00029	Huntington disease	P00790	beta-Tubulin	MACMU|Ensembl=ENSMMUG00000013187|UniProtKB=F6XQ37	Tubulin beta-1 chain	ISS	12932731	PubMed	PTHR11588:SF112	TUBULIN BETA-1 CHAIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IC	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	IDA	7600581	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00025	Hedgehog signaling pathway	P00682	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	XENTR|Xenbase=XB-GENE-491433|UniProtKB=B1H2U0	Pten protein	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06786	ERK1/2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	RCA	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00127	APP	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00018	EGF receptor signaling pathway	P00546	GAP	PANTR|Ensembl=ENSPTRG00000021317|UniProtKB=H2RC65	Uncharacterized protein	ISS	14735459	gi	PTHR10194:SF26	DISABLED HOMOLOG 2-INTERACTING PROTEIN
P00057	Wnt signaling pathway	P01465	Ggamma	RAT|RGD=1593806|UniProtKB=G3V8Y0	Protein Gng13	ISS	10391901	PubMed	PTHR15936:SF2	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-13
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	RCA	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00983	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	TAS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00049	Parkinson disease	P01226	CDCrel-1	HUMAN|HGNC=2879|UniProtKB=Q8WYJ6	Septin-1	IDA			PTHR18884:SF6	SEPTIN-1
P00049	Parkinson disease	P01235	Fyn kinase	PANTR|Ensembl=ENSPTRG00000018511|UniProtKB=H2QTK7	Tyrosine-protein kinase	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00029	Huntington disease	P00811	Arp2/3 complex	MACMU|Ensembl=ENSMMUG00000001458|UniProtKB=F7BKH1	Uncharacterized protein	ISS	9618202	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	IC	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P05913	Enkephalin release	P05972	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	CANLF|Ensembl=ENSCAFG00000019275|UniProtKB=E2QY91	Uncharacterized protein	ISS	7906389	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P06959	CCKR signaling map	G06996	MMP7	HUMAN|HGNC=7174|UniProtKB=P09237	Matrilysin	RCA	20150185	PubMed	PTHR10201:SF143	MATRILYSIN
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	HUMAN|HGNC=9721|UniProtKB=P32322	Pyrroline-5-carboxylate reductase 1, mitochondrial	ISS			PTHR11645:SF6	PYRROLINE-5-CARBOXYLATE REDUCTASE 1, MITOCHONDRIAL
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	PHYPA|Gene=PHYPADRAFT_97986|UniProtKB=A9TVX5	Predicted protein	ISS			PTHR23073:SF7	26S PROTEASE REGULATORY SUBUNIT 6A
P00018	EGF receptor signaling pathway	P00559	MEK1-2	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	PANTR|Gene=HTR2C|UniProtKB=Q5IS66	5-hydroxytryptamine receptor 2C	ISS	8143856	PubMed	PTHR24247:SF32	5-HYDROXYTRYPTAMINE RECEPTOR 2C
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00008	Axon guidance mediated by Slit/Robo	P00355	Rho	MOUSE|MGI=MGI=106028|UniProtKB=Q62159	Rho-related GTP-binding protein RhoC	ISS	14871999	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P05913	Enkephalin release	P05978	AC	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	TAKRU|Ensembl=ENSTRUG00000005961|UniProtKB=H2SQ04	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DICDI|dictyBase=DDB_G0269234|UniProtKB=P07830	Major actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MOUSE|MGI=MGI=2152453|UniProtKB=Q2NL51	Glycogen synthase kinase-3 alpha	ISS	11995474	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00030	Hypoxia response via HIF activation	P00824	PTEN	TAKRU|Ensembl=ENSTRUG00000009851|UniProtKB=H2TJ90	Uncharacterized protein	ISS	21455682	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	CHICK|Gene=CHRM3|UniProtKB=P49578	Muscarinic acetylcholine receptor M3	TAS	11166329	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00046	Oxidative stress response	P01134	cPLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00003	Alzheimer disease-amyloid secretase pathway	P00095	Nicastrin	CAEEL|WormBase=WBGene00000148|UniProtKB=Q23316	Nicastrin	IDA	10993067	PubMed	PTHR21092:SF0	NICASTRIN
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01161	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	3449797	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	HUMAN|HGNC=8862|UniProtKB=P10720	Platelet factor 4 variant	ISS	9910486	gi	PTHR10179:SF38	PLATELET FACTOR 4 VARIANT
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	CAEEL|WormBase=WBGene00001606|UniProtKB=Q9XVU2	GLutamiNe synthetase (Glutamate-ammonia ligase)	ISS			PTHR20852:SF39	GLUTAMINE SYNTHETASE  GLUTAMATE-AMMONIA LIGASE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01161	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00036	Interleukin signaling pathway	P00983	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01465	Ggamma	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00021	FGF signaling pathway	P00644	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	ISS	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00005	Angiogenesis	P00211	GSK3beta	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00035	Interferon-gamma signaling pathway	P00959	IFNGR1	RAT|RGD=620570|UniProtKB=Q6P6T3	Interferon gamma receptor 1	TAS	14525967	PubMed	PTHR20859:SF5	INTERFERON GAMMA RECEPTOR 1
P00046	Oxidative stress response	P01138	MKK4	PANTR|Ensembl=ENSPTRG00000008783|UniProtKB=H2QCA7	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00049	Parkinson disease	P01236	Casein kinase II	CAEEL|WormBase=WBGene00002196|UniProtKB=P28548	Casein kinase II subunit beta	IDA	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	HUMAN|HGNC=6206|UniProtKB=P17535	Transcription factor jun-D	ISS	10664585	PubMed	PTHR11462:SF7	TRANSCRIPTION FACTOR JUN-D
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01082	AC	LEPIN|EnsemblGenome=LA_4008|UniProtKB=Q8EZ52	Adenylate/guanylate cyclase	IC	9874775	PubMed	PTHR16305:SF38	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00641	SOS	DICDI|dictyBase=DDB_G0269222|UniProtKB=Q8IS21	Ras guanine nucleotide exchange factor B	IGI			PTHR23113:SF163	RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR B
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05913	Enkephalin release	P05977	G-Protein (s)	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95816|UniProtKB=B1AS29	Glutamate receptor ionotropic, kainate 3	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	RAT|RGD=2917|UniProtKB=P15127	Insulin receptor	ISS	6754360	gi	PTHR24416:SF402	INSULIN RECEPTOR
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	YEAST|SGD=S000001069|UniProtKB=P38764	26S proteasome regulatory subunit RPN1	ISS			PTHR10943:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02781	Threonine biosynthesis	P03192	Aspartate semialdehyde dehydrogenase	ARATH|TAIR=AT1G01630|UniProtKB=Q9LQ96	Polyphosphoinositide binding protein, putative	ISS			PTHR10174:SF198	BINDING PROTEIN, PUTATIVE-RELATED
P00009	Axon guidance mediated by netrin	P00361	Ena	CHICK|Ensembl=ENSGALG00000009303|UniProtKB=F6QJK6	Uncharacterized protein	ISS			PTHR11202:SF1	PROTEIN ENABLED HOMOLOG
P06664	Gonadotropin-releasing hormone receptor pathway	G06894	c-fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	RCA	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00006	Apoptosis signaling pathway	P00269	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00570	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P02734	Chorismate biosynthesis	P02870	3-Phosphoshikimate-1-carboxyvinyl transferase	FUSNN|EnsemblGenome=FN0933|UniProtKB=Q8REZ7	3-phosphoshikimate 1-carboxyvinyltransferase	ISS			PTHR21090:SF5	PENTAFUNCTIONAL AROM POLYPEPTIDE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01411	Ras	DICDI|dictyBase=DDB_G0292998|UniProtKB=P32252	Ras-like protein rasB	ISS	93205383	PubMed	PTHR24070:SF206	RAS-LIKE PROTEIN RASB
P00047	PDGF signaling pathway	P01174	Rho	CANLF|Ensembl=ENSCAFG00000009147|UniProtKB=A4GT58	Cdc42 GTPase-activating protein	ISS	14724572	PubMed	PTHR23176:SF28	RHO GTPASE-ACTIVATING PROTEIN 1
P00005	Angiogenesis	P00206	Wnt	HUMAN|HGNC=12786|UniProtKB=O00755	Protein Wnt-7a	IEP	12549854	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P04397	p53 pathway by glucose deprivation	P04637	4E-BP1	CANLF|Ensembl=ENSCAFG00000006154|UniProtKB=F1PZE3	Uncharacterized protein	ISS	12820960	PubMed	PTHR12669:SF14	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00036	Interleukin signaling pathway	P00981	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00034	Integrin signalling pathway	P00925	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05731	GABA-B receptor II signaling	P05752	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00047	PDGF signaling pathway	P01163	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	8837781	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00057	Wnt signaling pathway	P01431	LRP5/6	CANLF|Ensembl=ENSCAFG00000013324|UniProtKB=F1PCS0	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00053	T cell activation	P01331	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IDA	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04397	p53 pathway by glucose deprivation	P04641	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06850	PKCs(3)	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	RCA	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00037	Ionotropic glutamate receptor pathway	P01020	NSF	RAT|RGD=621594|UniProtKB=Q9QUL6	Vesicle-fusing ATPase	ISS	7969419	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01087	CAT	CANLF|Ensembl=ENSCAFG00000006672|UniProtKB=F1PR75	Uncharacterized protein	ISS	97225904	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12176041	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	BOVIN|Gene=DHFR|UniProtKB=P00376	Dihydrofolate reductase	ISS			PTHR22778:SF16	DIHYDROFOLATE REDUCTASE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	ANOGA|EnsemblGenome=AGAP000300|UniProtKB=Q7QF47	AGAP000300-PA	ISS			PTHR11405:SF5	CAD PROTEIN
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TRIAD|EnsemblGenome=TriadG49626|UniProtKB=B3RKR4	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	MOUSE|MGI=MGI=98181|UniProtKB=P11157	Ribonucleoside-diphosphate reductase subunit M2	ISS			PTHR23409:SF20	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	HUMAN|HGNC=9995|UniProtKB=O14921	Regulator of G-protein signaling 13	IDA	12193720	PubMed	PTHR10845:SF32	REGULATOR OF G-PROTEIN SIGNALING 13
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	MONDO|Ensembl=ENSMODG00000011192|UniProtKB=F6SRK5	Uncharacterized protein	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	TAS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000025373|UniProtKB=F6ZZG9	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	HUMAN|HGNC=4586|UniProtKB=Q13224	Glutamate receptor ionotropic, NMDA 2B	IC	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	ANOGA|EnsemblGenome=AGAP011481|UniProtKB=Q7PMY1	AGAP011481-PA (Fragment)	IDA			PTHR24247:SF117	5-HYDROXYTRYPTAMINE RECEPTOR 2A-RELATED
P00021	FGF signaling pathway	P00633	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00010	B cell activation	P00381	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00007	Axon guidance mediated by semaphorins	P00334	PlexinA1	RAT|RGD=1560871|UniProtKB=D3Z981	Protein Plxna1	ISS	10725340	PubMed	PTHR22625:SF35	PLEXIN-A1
P04398	p53 pathway feedback loops 2	P04665	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00589	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	IGI	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00047	PDGF signaling pathway	P01157	MAPKAPK2	BOVIN|Ensembl=ENSBTAG00000038107|UniProtKB=F1MCX5	Uncharacterized protein	ISS	7923354	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00034	Integrin signalling pathway	P00925	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06850	PKCs(3)	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	RCA	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IC	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P06664	Gonadotropin-releasing hormone receptor pathway	P06819	SMAD2-4	MOUSE|MGI=MGI=1328787|UniProtKB=P97454	Mothers against decapentaplegic homolog 5	RCA	12736218	PubMed	PTHR13703:SF36	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00008	Axon guidance mediated by Slit/Robo	P00344	Netrin	XENTR|Xenbase=XB-GENE-989335|UniProtKB=F7CBX5	Uncharacterized protein (Fragment)	ISS	9427245	PubMed	PTHR10574:SF365	NETRIN-1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00057	Wnt signaling pathway	P01456	beta-arrestin	HUMAN|HGNC=710|UniProtKB=P36575	Arrestin-C	IC	11742073	PubMed	PTHR11792:SF19	ARRESTIN-C
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02771	Pyrimidine Metabolism	P03128	Dihydrouracil Dehydrogenase	MOUSE|MGI=MGI=2139667|UniProtKB=Q8CHR6	Dihydropyrimidine dehydrogenase [NADP(+)]	ISS	8912928	PubMed	PTHR43073:SF2	DIHYDROPYRIMIDINE DEHYDROGENASE  NADP +
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04395	Vasopressin synthesis	P04594	Neurophysin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00006	Apoptosis signaling pathway	P00321	HSP70	MOUSE|MGI=MGI=99517|UniProtKB=P17879	Heat shock 70 kDa protein 1B	ISS	12150907	PubMed	PTHR19375:SF223	HEAT SHOCK 70 KDA PROTEIN 1A-RELATED
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_115565|UniProtKB=C3XYD3	Putative uncharacterized protein	ISS			PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P05731	GABA-B receptor II signaling	P05752	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_114976|UniProtKB=C3YP58	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01443	Phospholipase C	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00048	PI3 kinase pathway	P01192	p110	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04397	p53 pathway by glucose deprivation	G04706	TSC2	HUMAN|HGNC=12363|UniProtKB=P49815	Tuberin	ISS	12150915	PubMed	PTHR10063:SF0	TUBERIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=1351338|UniProtKB=P97772	Metabotropic glutamate receptor 1	IDA			PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00057	Wnt signaling pathway	P01438	PP2A	MACMU|Ensembl=ENSMMUG00000020819|UniProtKB=F7HSM1	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00912	Arp2/3	CHICK|Ensembl=ENSGALG00000011452|UniProtKB=F1P1K3	Uncharacterized protein	ISS	10940259	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Gene=HTR1D|UniProtKB=P11614	5-hydroxytryptamine receptor 1D	IDA	12181435	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	XENTR|Xenbase=XB-GENE-482185|UniProtKB=Q6GLE7	Tubulin beta chain	ISS	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	HUMAN|HGNC=143|UniProtKB=P68032	Actin, alpha cardiac muscle 1	IC	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00045	Notch signaling pathway	P01104	Serrate	RAT|RGD=2937|UniProtKB=Q63722	Protein jagged-1	IDA	8955070	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00049	Parkinson disease	P01211	ERK	DICDI|dictyBase=DDB_G0283903|UniProtKB=Q54QB1	Extracellular signal-regulated kinase 2	IDA	12787066	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00025	Hedgehog signaling pathway	P00682	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01451	Galpha	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	IDA	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00053	T cell activation	P01305	Calmodulin	BOVIN|Ensembl=ENSBTAG00000014583|UniProtKB=P62157	Calmodulin	ISS	3885394	PubMed	PTHR23050:SF335	CALMODULIN, STRIATED MUSCLE
P00049	Parkinson disease	P01230	Src kinase	DROME|FlyBase=FBgn0264959|UniProtKB=Q9V9J3	Tyrosine-protein kinase Src42A	IDA	8054685	PubMed	PTHR24418:SF292	TYROSINE-PROTEIN KINASE SRC42A
P05918	p38 MAPK pathway	P06029	p38beta	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	RCA	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00056	VEGF signaling pathway	P01413	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MACMU|Ensembl=ENSMMUG00000014807|UniProtKB=F6W548	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CAEBR|Gene=CBG02162|UniProtKB=A8WS33	Protein CBG02162	ISS	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00010	B cell activation	P00373	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IGI	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MONDO|Ensembl=ENSMODG00000011428|UniProtKB=F6RKF7	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF34	FRIZZLED-2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	P01465	Ggamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	CAEEL|WormBase=WBGene00006390|UniProtKB=Q7YTH5	TAF (TBP-associated transcription factor) family	ISS	604903	OMIM	PTHR12321:SF78	TAF  TBP-ASSOCIATED TRANSCRIPTION FACTOR  FAMILY
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	10218114	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	CAEEL|WormBase=WBGene00012316|UniProtKB=G5EC98	CTP synthase	ISS			PTHR11550:SF0	CTP SYNTHASE
P00006	Apoptosis signaling pathway	P00269	MAPK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	IDA	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IDA	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04393	Ras Pathway	P04566	Stat 1/3	BOVIN|Gene=STAT3|UniProtKB=P61635	Signal transducer and activator of transcription 3	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00050	Plasminogen activating cascade	P01254	pro-MMP-13	RAT|RGD=620196|UniProtKB=P23097	Collagenase 3 (Fragment)	ISS	1383028	PubMed	PTHR10201:SF165	COLLAGENASE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DANRE|ZFIN=ZDB-GENE-030131-55|UniProtKB=Q6XNL8	Actin	IC	11889139	PubMed	PTHR11937:SF263	ACTIN
P00005	Angiogenesis	P00223	Akt	CAEEL|WormBase=WBGene00000103|UniProtKB=Q9XTG7	Serine/threonine-protein kinase akt-2	ISS			PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	IC	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	CHICK|Ensembl=ENSGALG00000007039|UniProtKB=F1NG99	Tyrosine-protein kinase receptor	ISS	249616	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P05916	Opioid prodynorphin pathway	P06000	vasopressin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00014	Cholesterol biosynthesis	P00491	Hydroxymethyl glutaryl CoA reductase	RAT|RGD=2803|UniProtKB=P51639	3-hydroxy-3-methylglutaryl-coenzyme A reductase	ISS	P09610	SPACC	PTHR10572:SF2	3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04585	TRH	MACMU|Ensembl=ENSMMUG00000009962|UniProtKB=F6RBM2	Thyroid stimulating hormone beta subunit	ISS			PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	MOUSE|MGI=MGI=95818|UniProtKB=Q61626	Glutamate receptor ionotropic, kainate 5	ISS	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00023	General transcription regulation	P00668	TFIIB	RAT|RGD=1308817|UniProtKB=Q4V8D6	Transcription factor IIIB 50 kDa subunit	ISS			PTHR11618:SF5	TRANSCRIPTION FACTOR IIIB 50 KDA SUBUNIT
P05918	p38 MAPK pathway	P06031	p38alpha	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	RCA	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00025	Hedgehog signaling pathway	P00691	CBP	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=2150308|UniProtKB=Q8K4D7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1	ISS	12860966	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	PANTR|Ensembl=ENSPTRG00000023608|UniProtKB=H2QZZ2	Uncharacterized protein	ISS	11319238	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00048	PI3 kinase pathway	P01187	IR	HUMAN|HGNC=6091|UniProtKB=P06213	Insulin receptor	ISS	249616	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00052	TGF-beta signaling pathway	P01275	P38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	TAS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	SCHPO|PomBase=SPAC922.07c|UniProtKB=Q9URW9	Putative aldehyde dehydrogenase-like protein C922.07c	IC			PTHR43720:SF1	ALDEHYDE DEHYDROGENASE  NAD P +  1-RELATED
P00059	p53 pathway	G04694	p110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00020	FAS signaling pathway	P00615	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00010	B cell activation	P00383	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IDA	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	MACMU|Ensembl=ENSMMUG00000007524|UniProtKB=F6QCQ2	Uncharacterized protein	ISS	606023	OMIM	PTHR10917:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00005	Angiogenesis	P00221	JNK1	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00572	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P02768	Proline biosynthesis	P03112	Glutamate semialdehyde dehydrogenase	PSEAE|EnsemblGenome=PA4007|UniProtKB=Q9HX20	Gamma-glutamyl phosphate reductase	ISS			PTHR11063:SF8	DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	G06894	c-fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	RCA	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	MONDO|Ensembl=ENSMODG00000020981|UniProtKB=F6S570	Uncharacterized protein	ISS			PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	LEIMA|EnsemblGenome=LmjF.35.4010|UniProtKB=Q9GNR4	Protein kinase A catalytic subunit isoform 1	ISS	10553940	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00038	JAK/STAT signaling pathway	P01027	STAT	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	PANTR|Ensembl=ENSPTRG00000002086|UniProtKB=H2Q1A9	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	BOVIN|Ensembl=ENSBTAG00000018777|UniProtKB=E1BHU9	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IC	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00059	p53 pathway	P04633	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01275	P38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	TAS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00896	Insulin IGF	CHICK|Ensembl=ENSGALG00000006552|UniProtKB=P67970	Insulin	ISS			PTHR11454:SF9	INSULIN-RELATED
P00017	DNA replication	P00527	Histones	EMENI|EnsemblGenome=CADANIAG00001930|UniProtKB=P23753	Histone H3	ISS	12413958	PubMed	PTHR11426:SF169	HISTONE H3
P00045	Notch signaling pathway	P01115	Neurotic	MOUSE|MGI=MGI=1858901|UniProtKB=Q9WTS2	Alpha-(1,6)-fucosyltransferase	ISS			PTHR13132:SF29	ALPHA- 1,6 -FUCOSYLTRANSFERASE
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	MOUSE|MGI=MGI=1351342|UniProtKB=Q3UVX5	Metabotropic glutamate receptor 5	ISS	8314195	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00021	FGF signaling pathway	P00632	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01368	MKK2	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	HUMAN|HGNC=4594|UniProtKB=Q14416	Metabotropic glutamate receptor 2	ISS	12488551	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00006	Apoptosis signaling pathway	P00311	GCKR	BOVIN|Ensembl=ENSBTAG00000014792|UniProtKB=F1N2U3	Mitogen-activated protein kinase kinase kinase kinase	ISS			PTHR24361:SF324	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 5
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	RAT|RGD=68409|UniProtKB=Q9JLJ3	4-trimethylaminobutyraldehyde dehydrogenase	IC			PTHR11699:SF228	4-TRIMETHYLAMINOBUTYRALDEHYDE DEHYDROGENASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00034	Integrin signalling pathway	P00932	FAK	MOUSE|MGI=MGI=95481|UniProtKB=P34152	Focal adhesion kinase 1	IPI	9182576	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	IDA	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00006	Apoptosis signaling pathway	P00274	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00017	DNA replication	P00527	Histones	BOVIN|Ensembl=ENSBTAG00000024175|UniProtKB=P68432	Histone H3.1	ISS	20448842	PubMed	PTHR11426:SF167	HISTONE H3.1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000023940|UniProtKB=F6RFW8	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04398	p53 pathway feedback loops 2	P04662	cyclin G	PANTR|Ensembl=ENSPTRG00000017501|UniProtKB=H2QRY5	Cyclin G1	ISS			PTHR10177:SF59	CYCLIN-G1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	IC	14744463	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00049	Parkinson disease	P01238	14-3-3	RAT|RGD=61998|UniProtKB=P35213	14-3-3 protein beta/alpha	ISS	91108808	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01332	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00260	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01352	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02738	De novo purine biosynthesis	P02901	Adenosuccinate lyase	CAEEL|WormBase=WBGene00011064|UniProtKB=Q21774	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	ORYSJ|EnsemblGenome=OS03G0174500|UniProtKB=Q10R17	Adenylosuccinate synthetase 1, chloroplastic	ISS	10636885	PubMed	PTHR11846:SF4	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00547	PP2A	DICDI|dictyBase=DDB_G0290263|UniProtKB=Q9XZE5	Serine/threonine-protein phosphatase 2A catalytic subunit A	IGI	10452519	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00012	Cadherin signaling pathway	P00465	TCF/LEF	MACMU|Ensembl=ENSMMUG00000020134|UniProtKB=F6U055	Uncharacterized protein	ISS	12356903	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00021	FGF signaling pathway	P00624	14-3-3	DANRE|ZFIN=ZDB-GENE-030131-6583|UniProtKB=Q5PRD0	14-3-3 protein beta/alpha-A	ISS	21864508	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00010	B cell activation	P00386	Calcineurin	CANLF|Ensembl=ENSCAFG00000010644|UniProtKB=F2Z4P5	Serine/threonine-protein phosphatase	ISS	12091710	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00011	Blood coagulation	P00458	GP IIIa	XENTR|Xenbase=XB-GENE-1009964|UniProtKB=F6SRR1	Integrin beta (Fragment)	ISS	2119641	gi	PTHR10082:SF25	INTEGRIN BETA-3
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01332	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IDA	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04561	SRF	MACMU|Ensembl=ENSMMUG00000000033|UniProtKB=F7G4D2	Uncharacterized protein	ISS	8660892	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00047	PDGF signaling pathway	P01160	IP3 receptor	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02752	Mannose metabolism	P03019	P-Mannose mutase	RAT|RGD=1309366|UniProtKB=B5DF46	Phosphomannomutase	ISS	11042159	PubMed	PTHR10466:SF2	PHOSPHOMANNOMUTASE 2
P00010	B cell activation	P00398	IP3R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00036	Interleukin signaling pathway	P00973	PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01438	PP2A	RAT|RGD=6503746|UniProtKB=Q80W83	Protein LOC100909468	ISS	10092233	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8689|UniProtKB=Q9Y5E5	Protocadherin beta-4	IDA	8120095	PubMed	PTHR24028:SF55	PROTOCADHERIN BETA-4
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00049	Parkinson disease	P01242	Casein kinase I	HUMAN|HGNC=2453|UniProtKB=P49674	Casein kinase I isoform epsilon	IDA	11865049	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00006	Apoptosis signaling pathway	P00310	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	BRAFL|Gene=BRAFLDRAFT_60743|UniProtKB=C3XYD4	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00036	Interleukin signaling pathway	P00973	PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	RCA	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	XENTR|Xenbase=XB-GENE-1005779|UniProtKB=F7E3I6	Uncharacterized protein	ISS	2137198	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00010	B cell activation	P00376	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	HUMAN|HGNC=9509|UniProtKB=P49810	Presenilin-2	IDA	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	DROME|FlyBase=FBgn0000036|UniProtKB=P09478	Acetylcholine receptor subunit alpha-like 1	ISS	85270494	PubMed	PTHR18945:SF592	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-LIKE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00807	Actin	ORYSJ|EnsemblGenome=OS03G0718100|UniProtKB=Q10DV7	Actin-1	IDA	14684598	PubMed	PTHR11937:SF364	ACTIN-11
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1718748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	PANTR|Ensembl=ENSPTRG00000004148|UniProtKB=H2Q4I6	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF23	FRIZZLED-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=620023|UniProtKB=P10980	Muscarinic acetylcholine receptor M2	IDA	10069496	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	HUMAN|HGNC=703|UniProtKB=Q92747	Actin-related protein 2/3 complex subunit 1A	ISS	12932731	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00010	B cell activation	P00380	fos	RAT|RGD=2626|UniProtKB=P12841	Proto-oncogene c-Fos	TAS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00056	VEGF signaling pathway	P01425	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00920	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00053	T cell activation	P01332	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IDA	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01145	c-fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	TAS	8925912	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04397	p53 pathway by glucose deprivation	P04641	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06710	Junc	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	RCA	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	DANRE|ZFIN=ZDB-GENE-020503-1|UniProtKB=Q1LWJ4	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF498	TYROSINE-PROTEIN KINASE RECEPTOR
P06213	DPP signaling pathway	P06288	MAD	DROME|FlyBase=FBgn0011648|UniProtKB=P42003	Protein mothers against dpp	IGI	12736218	PubMed	PTHR13703:SF40	PROTEIN MOTHERS AGAINST DPP
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00005	Angiogenesis	P00212	EphR	RAT|RGD=2556|UniProtKB=P09759	Ephrin type-B receptor 1	RCA			PTHR24416:SF173	EPHRIN TYPE-B RECEPTOR 1
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	PANTR|Ensembl=ENSPTRG00000019449|UniProtKB=H2QV01	Actin related protein 2/3 complex, subunit 1B, 41kDa	ISS	12473693	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00018	EGF receptor signaling pathway	P00564	Rac	DICPU|Gene=DICPUDRAFT_55703|UniProtKB=F0ZN94	Putative uncharacterized protein racC	ISS	94124042	PubMed	PTHR24072:SF117	RHO-RELATED PROTEIN RACC
P02738	De novo purine biosynthesis	P02907	dADP kinase	HUMAN|HGNC=20567|UniProtKB=O75414	Nucleoside diphosphate kinase 6	ISS			PTHR11349:SF70	NUCLEOSIDE DIPHOSPHATE KINASE 6
P00056	VEGF signaling pathway	P01419	Ets	MACMU|Ensembl=ENSMMUG00000020706|UniProtKB=F6PU72	Uncharacterized protein	ISS	3060801	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00899	IRS 1-4	PANTR|Ensembl=ENSPTRG00000012989|UniProtKB=H2QJJ4	Insulin receptor substrate 1	ISS	12701063	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P02749	Leucine biosynthesis	P03000	Branched chain amino acid aminotransferase	YEAST|SGD=S000001251|UniProtKB=P38891	Branched-chain-amino-acid aminotransferase, mitochondrial	ISS			PTHR11825:SF44	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P00021	FGF signaling pathway	P00633	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00019	Endothelin signaling pathway	P00587	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00053	T cell activation	P01316	MHC-antigen	PANTR|Ensembl=ENSPTRG00000018025|UniProtKB=H2QSS0	Uncharacterized protein	ISS	3112582	PubMed	PTHR19944:SF65	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DM BETA CHAIN
P00059	p53 pathway	P04630	PP2A	HUMAN|HGNC=9299|UniProtKB=P67775	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01307	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	CHICK|Gene=FYN|UniProtKB=Q05876	Tyrosine-protein kinase Fyn	ISS	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	HUMAN|HGNC=9300|UniProtKB=P62714	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	DROME|FlyBase=FBgn0019947|UniProtKB=O02194	Presenilin homolog	TAS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00046	Oxidative stress response	P01135	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	TAS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00034	Integrin signalling pathway	P00951	Jnk	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	11256888	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04558	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2747|UniProtKB=P35349	Metabotropic glutamate receptor 6	IDA	9407094	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	MOUSE|MGI=MGI=88543|UniProtKB=Q60737	Casein kinase II subunit alpha	IDA	10617630	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	TAS	15572354	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00010	B cell activation	P00381	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00759	PDEalphabeta	HUMAN|HGNC=8785|UniProtKB=P16499	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	RCA	7493036	PubMed	PTHR11347:SF115	ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA
P00021	FGF signaling pathway	P00627	ERK1-2	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05918	p38 MAPK pathway	P05921	MKP5	HUMAN|HGNC=3065|UniProtKB=Q9Y6W6	Dual specificity protein phosphatase 10	RCA	11856337	PubMed	PTHR10159:SF299	DUAL SPECIFICITY PROTEIN PHOSPHATASE 10
P00029	Huntington disease	P00807	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g210933|UniProtKB=A7SEA7	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00019	Endothelin signaling pathway	P00589	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00047	PDGF signaling pathway	P01143	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00051	TCA cycle	P01273	Succinate Dehydrogenase	CANLF|Ensembl=ENSCAFG00000012992|UniProtKB=E2R9X4	Uncharacterized protein (Fragment)	ISS	11897817	PubMed	PTHR10978:SF5	SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00034	Integrin signalling pathway	P00918	Caveolin	TAKRU|Gene=cav1|UniProtKB=Q9YGM8	Caveolin-1	IPI	9741627	PubMed	PTHR10844:SF18	CAVEOLIN-1
P00001	Adrenaline and noradrenaline biosynthesis	P00062	TH	RAT|RGD=3853|UniProtKB=P04177	Tyrosine 3-monooxygenase	ISS	12814656	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00057	Wnt signaling pathway	P01444	Wnt	DANRE|ZFIN=ZDB-GENE-990603-12|UniProtKB=O73864	Protein Wnt-11	IDA	11266476	PubMed	PTHR12027:SF34	PROTEIN WNT
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01162	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00006	Apoptosis signaling pathway	P00302	ATF	CANLF|Ensembl=ENSCAFG00000013332|UniProtKB=F1PCQ4	Uncharacterized protein	ISS	15218628	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00018	EGF receptor signaling pathway	P00558	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05918	p38 MAPK pathway	P06015	p38gamma	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00021	FGF signaling pathway	P00627	ERK1-2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	GIAIC|EnsemblGenome=GL50803_96994|UniProtKB=E2RTW9	Syntaxin 1A	IC			PTHR19957:SF41	SYNTAXIN-1A
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00029	Huntington disease	P00779	TBP	ENTHI|Gene=EHI_020610|UniProtKB=P52653	TATA-box-binding protein 1	IPI	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MOUSE|MGI=MGI=1095407|UniProtKB=O35607	Bone morphogenetic protein receptor type-2	TAS	9395284	PubMed	PTHR23255:SF63	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000005862|UniProtKB=F1PL99	Phosphoinositide phospholipase C	ISS			PTHR10336:SF84	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2
P00012	Cadherin signaling pathway	P00470	F-actin	ARATH|TAIR=AT3G46520|UniProtKB=P53497	Actin-12	IC	10974003	PubMed	PTHR11937:SF276	ACTIN-12
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00036	Interleukin signaling pathway	P00994	FKHRL1	RAT|RGD=1309196|UniProtKB=D3ZBQ1	Forkhead box O3a (Predicted)	ISS	12884295	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00057	Wnt signaling pathway	P01438	PP2A	MOUSE|MGI=MGI=1321159|UniProtKB=P63330	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P06587	Nicotine pharmacodynamics pathway	P06590	GNG	HUMAN|HGNC=4404|UniProtKB=P59768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00056	VEGF signaling pathway	P01407	Erk	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00023	General transcription regulation	P00668	TFIIB	METJA|EnsemblGenome=MJ_0782|UniProtKB=Q58192	Transcription initiation factor IIB	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P00056	VEGF signaling pathway	P01417	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02761	Pantothenate biosynthesis	P03069	2-Dehydropantoate reductase	SCHPO|PomBase=SPBPB2B2.09c|UniProtKB=Q9HDU6	Probable 2-dehydropantoate 2-reductase	ISS			PTHR43765:SF2	2-DEHYDROPANTOATE 2-REDUCTASE-RELATED
P04397	p53 pathway by glucose deprivation	P04637	4E-BP1	MACMU|Ensembl=ENSMMUG00000002342|UniProtKB=F7C5U8	Uncharacterized protein	ISS	12820960	PubMed	PTHR12669:SF14	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01414	PLC-gamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00036	Interleukin signaling pathway	P00981	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04384	Gamma-aminobutyric acid synthesis	P04482	Glutamate decarboxylase	BOVIN|Ensembl=ENSBTAG00000007258|UniProtKB=Q0VCA1	Glutamate decarboxylase 1	ISS	2247446	PubMed	PTHR11999:SF57	GLUTAMATE DECARBOXYLASE 1
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	BOVIN|Ensembl=ENSBTAG00000018445|UniProtKB=E1BK87	Uncharacterized protein	ISS	11554554	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	TAS	10747026	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00011	Blood coagulation	P00414	Thrombin	RAT|RGD=61996|UniProtKB=P18292	Prothrombin	ISS	6753798	gi	PTHR24254:SF10	PROTHROMBIN
P00012	Cadherin signaling pathway	P00470	F-actin	ORYSJ|EnsemblGenome=OS05G0438800|UniProtKB=Q75HX0	Actin	IC	11889126	PubMed	PTHR11937:SF248	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01306	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00019	Endothelin signaling pathway	P00566	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	MONDO|Ensembl=ENSMODG00000015761|UniProtKB=F6ZT50	Uncharacterized protein	ISS	10851247	PubMed	PTHR11647:SF58	DIHYDROPYRIMIDINASE-RELATED PROTEIN 5
P00037	Ionotropic glutamate receptor pathway	P01001	KA4	MONDO|Ensembl=ENSMODG00000013079|UniProtKB=F7FB74	Uncharacterized protein	ISS	1648176	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02761	Pantothenate biosynthesis	P03068	Pantoate-beta-alanine ligase	GLOVI|EnsemblGenome=BAC89747|UniProtKB=Q7NJM6	Bifunctional pantoate ligase/cytidylate kinase	ISS			PTHR21299:SF2	CYTIDYLATE KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	PANTR|Ensembl=ENSPTRG00000008768|UniProtKB=H2QC98	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF368	MYOSIN-8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04585	TRH	RAT|RGD=3903|UniProtKB=P01150	Pro-thyrotropin-releasing hormone	ISS	2126343	PubMed	PTHR17530:SF2	PRO-THYROTROPIN-RELEASING HORMONE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00034	Integrin signalling pathway	P00925	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IDA	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00005	Angiogenesis	P00223	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00046	Oxidative stress response	P01126	ATF2	CHICK|Ensembl=ENSGALG00000009287|UniProtKB=O93602	Cyclic AMP-dependent transcription factor ATF-2	TAS	11390664	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00012	Cadherin signaling pathway	P00474	Wnt	MACMU|Ensembl=ENSMMUG00000000180|UniProtKB=F7HJM7	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	NAS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00557	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEEL|WormBase=WBGene00018620|UniProtKB=O44588	Uncharacterized protein	ISS	2837282	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	MOUSE|MGI=MGI=1919785|UniProtKB=Q9CZS1	Aldehyde dehydrogenase X, mitochondrial	IC			PTHR11699:SF207	ALDEHYDE DEHYDROGENASE X, MITOCHONDRIAL
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=101848|UniProtKB=P62881	Guanine nucleotide-binding protein subunit beta-5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	RAT|RGD=621060|UniProtKB=O88777	Presenilin-2	TAS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00029	Huntington disease	P00786	ARF	MACMU|Ensembl=ENSMMUG00000002792|UniProtKB=F7H235	ADP-ribosylation factor 1	ISS	12932731	PubMed	PTHR11711:SF294	ADP-RIBOSYLATION FACTOR 3
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	XENTR|Xenbase=XB-GENE-961282|UniProtKB=Q6DF43	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00029	Huntington disease	P00796	Kainate receptor	RAT|RGD=71027|UniProtKB=P42264	Glutamate receptor ionotropic, kainate 3	IDA	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MACMU|Ensembl=ENSMMUG00000009771|UniProtKB=F6ZHU6	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF681	MYOSIN-4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00005	Angiogenesis	P00206	Wnt	HUMAN|HGNC=12774|UniProtKB=P04628	Proto-oncogene Wnt-1	IDA	14644163	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	THEKO|EnsemblGenome=TK0132|UniProtKB=Q52366	TATA-box-binding protein	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00006	Apoptosis signaling pathway	P00274	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IDA	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00021	FGF signaling pathway	P00628	JNK1-3	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IC	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00034	Integrin signalling pathway	P00924	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00051	TCA cycle	P01267	Citrate Synthase	MOUSE|MGI=MGI=88529|UniProtKB=Q9CZU6	Citrate synthase, mitochondrial	RCA			PTHR11739:SF8	CITRATE SYNTHASE, MITOCHONDRIAL
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IDA	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00049	Parkinson disease	P01226	CDCrel-1	XENTR|Xenbase=XB-GENE-480201|UniProtKB=A1L0Y5	Septin-2B	ISS			PTHR18884:SF67	SEPTIN-2
P04393	Ras Pathway	P04558	p38	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00047	PDGF signaling pathway	P01171	PLCgamma	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00019	Endothelin signaling pathway	P00589	Akt	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	IGI	12086862	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	CHICK|Ensembl=ENSGALG00000017238|UniProtKB=F1NWG3	Uncharacterized protein	ISS	14614461	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00019	Endothelin signaling pathway	P00586	Gq	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000005917|UniProtKB=F6QM53	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	DANRE|ZFIN=ZDB-GENE-040426-59|UniProtKB=Q6P045	Tyms protein	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00036	Interleukin signaling pathway	P00981	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00006	Apoptosis signaling pathway	P00320	SODD	MOUSE|MGI=MGI=1914634|UniProtKB=Q8CI61	BAG family molecular chaperone regulator 4	IDA	12706861	PubMed	PTHR12329:SF10	BAG FAMILY MOLECULAR CHAPERONE REGULATOR 4
P00023	General transcription regulation	P00667	TFIIFbeta	HUMAN|HGNC=4653|UniProtKB=P13984	General transcription factor IIF subunit 2	ISS			PTHR10445:SF0	GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000000289|UniProtKB=F7A9T0	Uncharacterized protein	ISS	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00054	Toll receptor signaling pathway	P01369	MKK1	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00778	NMDA receptor	DANRE|ZFIN=ZDB-GENE-051202-1|UniProtKB=E7F101	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF2	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00577	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IGI	14526383	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00574	Big ET1-4	RAT|RGD=2532|UniProtKB=P22388	Endothelin-1	ISS	12773307	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P04393	Ras Pathway	P04567	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	RAT|RGD=2026|UniProtKB=P68035	Actin, alpha cardiac muscle 1	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P06664	Gonadotropin-releasing hormone receptor pathway	G06669	RICS	MOUSE|MGI=MGI=2450166|UniProtKB=Q811P8	Rho GTPase-activating protein 32	RCA			PTHR15729:SF9	RHO GTPASE-ACTIVATING PROTEIN 32
P00020	FAS signaling pathway	P00615	JNK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	TAS	10514528	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00036	Interleukin signaling pathway	P00983	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00916	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IPI	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	CANLF|Ensembl=ENSCAFG00000015043|UniProtKB=F1PVS9	Uncharacterized protein	TAS	Fang,Y.,Kitchell,B.E.,Paria,B.andBalkin,R.	free text	PTHR10201:SF165	COLLAGENASE 3
P00057	Wnt signaling pathway	P01444	Wnt	BRAFL|Gene=BRAFLDRAFT_56711|UniProtKB=C3XPR5	Protein Wnt	IDA	11266476	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04661	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00049	Parkinson disease	P01224	UbcH7	PANTR|Ensembl=ENSPTRG00000005754|UniProtKB=H2Q7D5	Uncharacterized protein	ISS	10888878	PubMed	PTHR24068:SF67	UBIQUITIN-CONJUGATING ENZYME E2 L3
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	TAS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00561	STAT	BOVIN|Gene=STAT5B|UniProtKB=Q9TUM3	Signal transducer and activator of transcription 5B	ISS	22320921	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00034	Integrin signalling pathway	P00947	Laminin	MOUSE|MGI=MGI=1888978|UniProtKB=Q9JI33	Netrin-4	IPI	2538453	PubMed	PTHR10574:SF282	NETRIN-4
P00053	T cell activation	P01304	Csk	CANLF|Ensembl=ENSCAFG00000017945|UniProtKB=E2RFF7	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00050	Plasminogen activating cascade	P01254	pro-MMP-13	RAT|RGD=631408|UniProtKB=O88766	Neutrophil collagenase	ISS			PTHR10201:SF137	NEUTROPHIL COLLAGENASE
P00030	Hypoxia response via HIF activation	P00819	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	TAS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04657	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00048	PI3 kinase pathway	P01192	p110	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00052	TGF-beta signaling pathway	P01286	TGFbeta	DANRE|ZFIN=ZDB-GENE-980526-442|UniProtKB=A8E7N9	Growth/differentiation factor 6-B	TAS	9759503	PubMed	PTHR11848:SF228	GROWTH/DIFFERENTIATION FACTOR 6-B
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00049	Parkinson disease	P01211	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	8946911	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	RAT|RGD=1586146|UniProtKB=G3V716	Protein Rgs20	ISS	8756726	PubMed	PTHR10845:SF175	REGULATOR OF G-PROTEIN SIGNALING 20
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02775	Salvage pyrimidine ribonucleotides	P03150	Uridine kinase	ARATH|TAIR=AT1G55820|UniProtKB=A4FVR1	GBF-interacting protein 1-like	ISS			PTHR12758:SF30	GBF-INTERACTING PROTEIN 1-LIKE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00048	PI3 kinase pathway	P01206	14-3-3	RAT|RGD=3980|UniProtKB=P63102	14-3-3 protein zeta/delta	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00053	T cell activation	P01306	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00036	Interleukin signaling pathway	P00965	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00005	Angiogenesis	P00256	PLC-gamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00011	Blood coagulation	P00442	FXII	MACMU|Ensembl=ENSMMUG00000019816|UniProtKB=F7FY72	Uncharacterized protein	ISS	4503629	gi	PTHR44246:SF3	COAGULATION FACTOR XII
P04397	p53 pathway by glucose deprivation	P04642	Rheb	BOVIN|Gene=RHEB|UniProtKB=Q56JV3	GTP-binding protein Rheb	ISS	12869586	PubMed	PTHR24070:SF264	GTP-BINDING PROTEIN RHEB
P02779	Thiamin biosynthesis	P03175	1-Deoxyxylulose-5-phosphate synthase	BACSU|EnsemblGenome=BSU24270|UniProtKB=P54523	1-deoxy-D-xylulose-5-phosphate synthase	ISS			PTHR43322:SF5	1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE 1-RELATED
P00012	Cadherin signaling pathway	P00477	GSK3beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	RAT|RGD=68942|UniProtKB=O54898	Voltage-dependent T-type calcium channel subunit alpha-1G	ISS	18021322	PubMed	PTHR10037:SF137	VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1G
P00034	Integrin signalling pathway	P00950	Paxillin	MOUSE|MGI=MGI=108295|UniProtKB=Q8VI36	Paxillin	IPI	9182576	PubMed	PTHR24216:SF11	PAXILLIN
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00034	Integrin signalling pathway	P00925	MEK	CANLF|Ensembl=ENSCAFG00000017851|UniProtKB=F1PBB6	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00053	T cell activation	P01312	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	TAS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00020	FAS signaling pathway	P00615	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008422|UniProtKB=F6VUT7	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	HUMAN|HGNC=12270|UniProtKB=Q9BQ50	Three prime repair exonuclease 2	ISS			PTHR13058:SF20	THREE PRIME REPAIR EXONUCLEASE 2
P00053	T cell activation	P01332	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01451	Galpha	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	IDA	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IC	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	IDA	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00005	Angiogenesis	P00243	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	8687404	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00045	Notch signaling pathway	P01110	Presenilin	BOVIN|Ensembl=ENSBTAG00000011757|UniProtKB=Q9XT97	Presenilin-1	ISS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12874273	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00005	Angiogenesis	P00226	Delta/Serrate	HUMAN|HGNC=6189|UniProtKB=Q9Y219	Protein jagged-2	ISS			PTHR44097:SF1	PROTEIN JAGGED-2
P00047	PDGF signaling pathway	P01174	Rho	HUMAN|HGNC=19744|UniProtKB=O43295	SLIT-ROBO Rho GTPase-activating protein 3	ISS			PTHR14166:SF8	SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 3
P00018	EGF receptor signaling pathway	P00565	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	2837282	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DICDI|dictyBase=DDB_G0286555|UniProtKB=P34147	Rho-related protein racA	ISS			PTHR24072:SF183	RHO-RELATED PROTEIN RACA
P02783	Tryptophan biosynthesis	P03208	Tryptophan synthase B	NEUCR|EnsemblGenome=EFNCRG00000007805|UniProtKB=P13228	Tryptophan synthase	ISS			PTHR42882:SF1	TRYPTOPHAN SYNTHASE
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00049	Parkinson disease	P01230	Src kinase	STRPU|EnsemblGenome=SPU_013522|UniProtKB=Q8WQM5	Tyrosine-protein kinase	IDA	11078745	PubMed	PTHR24418:SF292	TYROSINE-PROTEIN KINASE SRC42A
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	PANTR|Ensembl=ENSPTRG00000009215|UniProtKB=H2QD32	Uncharacterized protein	ISS	11821900	PubMed	PTHR10489:SF773	C-C CHEMOKINE RECEPTOR TYPE 10
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	IC	2837282	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00057	Wnt signaling pathway	P01444	Wnt	CHICK|Ensembl=ENSGALG00000004790|UniProtKB=P49337	Protein Wnt-4	IDA	11266476	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	MACMU|Ensembl=ENSMMUG00000003236|UniProtKB=F7DNS6	Uncharacterized protein	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00036	Interleukin signaling pathway	P00965	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	CHICK|Ensembl=ENSGALG00000004796|UniProtKB=Q90694	Cell division control protein 42 homolog	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P02734	Chorismate biosynthesis	P02869	3-Dehydroquinate dehydratase	BACSU|EnsemblGenome=BSU24470|UniProtKB=P54517	3-dehydroquinate dehydratase	ISS			PTHR21272:SF3	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MOUSE|MGI=MGI=88399|UniProtKB=P32211	Muscarinic acetylcholine receptor M4	TAS	10069496	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P05916	Opioid prodynorphin pathway	P06002	G-protein	DROME|FlyBase=FBgn0001122|UniProtKB=P16378	G protein alpha o subunit	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	MOUSE|MGI=MGI=1339975|UniProtKB=O88643	Serine/threonine-protein kinase PAK 1	ISS	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MACMU|Ensembl=ENSMMUG00000007027|UniProtKB=F7F210	Alpha-cardiac actin	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04396	Vitamin D metabolism and pathway	P04607	FDX	PSEAE|EnsemblGenome=PA3809|UniProtKB=Q51383	2Fe-2S ferredoxin	ISS			PTHR23426:SF34	2FE-2S FERREDOXIN
P00018	EGF receptor signaling pathway	P00561	STAT	BOVIN|Gene=STAT5B|UniProtKB=Q9TUM3	Signal transducer and activator of transcription 5B	ISS	96210005	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P04398	p53 pathway feedback loops 2	P04651	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P06664	Gonadotropin-releasing hormone receptor pathway	P06798	PKCe/theta	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01235	Fyn kinase	DANRE|ZFIN=ZDB-GENE-050706-89|UniProtKB=F1RDG9	Tyrosine-protein kinase fynb	ISS	9741627	PubMed	PTHR24418:SF242	TYROSINE-PROTEIN KINASE FYNB
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CANLF|Ensembl=ENSCAFG00000004381|UniProtKB=J9JH96	Uncharacterized protein	ISS	92317054	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MOUSE|MGI=MGI=1920960|UniProtKB=Q9CWF2	Tubulin beta-2B chain	ISS	12932731	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P06959	CCKR signaling map	P07090	MAPK8-10	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	RCA	12239223	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00019	Endothelin signaling pathway	P00590	IP3 R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IGI	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00047	PDGF signaling pathway	P01163	c-Jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=1923396|UniProtKB=Q8BVI5	Syntaxin-16	IC			PTHR19957:SF83	SYNTAXIN-16
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00053	T cell activation	P01305	Calmodulin	TAKRU|Ensembl=ENSTRUG00000008685|UniProtKB=H2TXN3	Uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF326	CALMODULIN
P04398	p53 pathway feedback loops 2	G04714	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MONDO|Ensembl=ENSMODG00000010521|UniProtKB=F7DQK7	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P02723	Adenine and hypoxanthine salvage pathway	P02809	Xanthine dehydrogenase	MOUSE|MGI=MGI=98973|UniProtKB=Q00519	Xanthine dehydrogenase/oxidase	ISS	12969896	PubMed	PTHR11908:SF80	XANTHINE DEHYDROGENASE/OXIDASE
P00010	B cell activation	P00367	NFAT	PANTR|Ensembl=ENSPTRG00000013628|UniProtKB=H2R4F5	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P02781	Threonine biosynthesis	P03190	Threonine synthase	HUMAN|HGNC=26160|UniProtKB=Q8IYQ7	Threonine synthase-like 1	ISS			PTHR43515:SF1	THREONINE SYNTHASE-LIKE 1
P00019	Endothelin signaling pathway	P00578	eNOS	RAT|RGD=3186|UniProtKB=Q62600	Nitric oxide synthase, endothelial	ISS	93055452	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MOUSE|MGI=MGI=102705|UniProtKB=P63213	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00029	Huntington disease	P00810	GAPDH	FUSNN|EnsemblGenome=FN0652|UniProtKB=Q8RFN9	Glyceraldehyde-3-phosphate dehydrogenase	ISS			PTHR43148:SF2	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE C-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000009085|UniProtKB=H2RDQ2	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00057	Wnt signaling pathway	P01446	Calcineurin	SCHPO|PomBase=SPBP4H10.04|UniProtKB=Q12705	Serine/threonine-protein phosphatase 2B catalytic subunit	IDA	12015605	PubMed	PTHR11668:SF118	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED
P02742	Tetrahydrofolate biosynthesis	P02951	GTP cyclohydrolase	SYNY3|EnsemblGenome=BAA10406|UniProtKB=Q55759	GTP cyclohydrolase 1	ISS			PTHR11109:SF0	GTP CYCLOHYDROLASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	XENTR|Ensembl=ENSXETG00000030140|UniProtKB=F7EP58	Uncharacterized protein (Fragment)	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00005	Angiogenesis	P00180	Dok-R	PANTR|Ensembl=ENSPTRG00000012100|UniProtKB=H2QI72	Docking protein 1, 62kDa (Downstream of tyrosine kinase 1)	ISS			PTHR21258:SF46	DOCKING PROTEIN 1
P02724	Alanine biosynthesis	P02815	Branched chain amino acid aminotransferase	DEIRA|EnsemblGenome=DR_1626|UniProtKB=Q9RTX5	Branched-chain-amino-acid aminotransferase	ISS			PTHR42825:SF2	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 3, CHLOROPLASTIC
P00012	Cadherin signaling pathway	P00474	Wnt	CHICK|Ensembl=ENSGALG00000014235|UniProtKB=Q3L254	Protein Wnt-7b	ISS	11266476	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05918	p38 MAPK pathway	P06024	eIF4E	BOVIN|Ensembl=ENSBTAG00000009522|UniProtKB=Q9N0T5	Eukaryotic translation initiation factor 4E	RCA			PTHR11960:SF14	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS			PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P02738	De novo purine biosynthesis	P02903	Phosphoribosylglycinamide  formyltransferase	THEMA|EnsemblGenome=TM_1248|UniProtKB=Q9X0X5	Phosphoribosylglycinamide formyltransferase	ISS			PTHR43369:SF2	PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE
P04393	Ras Pathway	P04570	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01284	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01154	Ras	DICDI|dictyBase=DDB_G0293434|UniProtKB=P15064	Ras-like protein rasG	ISS	89128893	PubMed	PTHR24070:SF282	RAS GTPASE-RELATED
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00048	PI3 kinase pathway	P01192	p110	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01438	PP2A	BOVIN|Ensembl=ENSBTAG00000000469|UniProtKB=P67774	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT1G10210|UniProtKB=Q39021	Mitogen-activated protein kinase 1	ISS	9836510	gi	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P04376	5HT4 type receptor mediated signaling pathway	P04427	5HT4 Receptor	BOVIN|Ensembl=ENSBTAG00000010837|UniProtKB=F1N3N9	Uncharacterized protein	ISS	15118808	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	XENTR|Xenbase=XB-GENE-950703|UniProtKB=Q5BJ72	MGC97603 protein	ISS			PTHR10410:SF5	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 14
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00012	Cadherin signaling pathway	P00475	Frizzled	XENTR|Xenbase=XB-GENE-480800|UniProtKB=F6VM33	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF90	FRIZZLED-8
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00006	Apoptosis signaling pathway	P00274	JNK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CANLF|Ensembl=ENSCAFG00000005662|UniProtKB=E2R907	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	ANOGA|EnsemblGenome=AGAP010929|UniProtKB=Q7PSI4	AGAP010929-PA	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DICDI|dictyBase=DDB_G0283907|UniProtKB=P34099	cAMP-dependent protein kinase catalytic subunit	IC	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00052	TGF-beta signaling pathway	P01284	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00053	T cell activation	P01319	PAK	MOUSE|MGI=MGI=1339656|UniProtKB=Q61036	Serine/threonine-protein kinase PAK 3	ISS	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00037	Ionotropic glutamate receptor pathway	P00998	stargazin	BOVIN|Ensembl=ENSBTAG00000012311|UniProtKB=E1BEI3	Voltage-dependent calcium channel gamma subunit	ISS	11140673	PubMed	PTHR12107:SF4	VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-5 SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05915	Opioid proenkephalin pathway	P05989	leu-Enkephalin	MACMU|Ensembl=ENSMMUG00000006775|UniProtKB=F7H3N8	Uncharacterized protein	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00019	Endothelin signaling pathway	P00586	Gq	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00570	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	10218114	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P02757	O-antigen biosynthesis	P03050	dTDP-4-dehydrorhamnose reductase	FUSNN|EnsemblGenome=FN1685|UniProtKB=Q8RIB7	dTDP-4-dehydrorhamnose reductase	ISS			PTHR43242:SF1	NAD P -BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01171	PLCgamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	DICDI|dictyBase=DDB_G0271906|UniProtKB=Q869Z3	Glutamate-tRNA ligase	ISS			PTHR43311:SF2	GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	CANLF|Ensembl=ENSCAFG00000000415|UniProtKB=E2R2K4	Uncharacterized protein	ISS	8576107	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00006	Apoptosis signaling pathway	P00269	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00925	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IDA	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000024633|UniProtKB=F1MBU9	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04380	Cortocotropin releasing factor receptor signaling pathway	G04671	proopiomelanocortin	MOUSE|MGI=MGI=97742|UniProtKB=P01193	Pro-opiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00021	FGF signaling pathway	P00629	PP2A	MONDO|Ensembl=ENSMODG00000014177|UniProtKB=F6U7A6	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ORNAN|Ensembl=ENSOANG00000007581|UniProtKB=F6QWB7	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00047	PDGF signaling pathway	P01160	IP3 receptor	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00030	Hypoxia response via HIF activation	P00824	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	TAS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P06664	Gonadotropin-releasing hormone receptor pathway	P06831	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	RCA	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00644	p38	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MACMU|Ensembl=ENSMMUG00000009054|UniProtKB=F7F735	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05731	GABA-B receptor II signaling	P05754	Ggamma	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	RCA	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00018	EGF receptor signaling pathway	P00562	p38	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P02738	De novo purine biosynthesis	P02904	Guanylate kinase	SCHPO|PomBase=SPBC1198.05|UniProtKB=Q9P6I5	Guanylate kinase	ISS			PTHR23117:SF13	GUANYLATE KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MOUSE|MGI=MGI=1338824|UniProtKB=O54828	Regulator of G-protein signaling 9	IDA	9459445	PubMed	PTHR10845:SF170	REGULATOR OF G-PROTEIN SIGNALING 9
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	EMENI|EnsemblGenome=CADANIAG00007315|UniProtKB=P20359	Actin, gamma	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P06959	CCKR signaling map	P07037	PLCgamma1	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	RCA	9437736	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00010	B cell activation	P00386	Calcineurin	RAT|RGD=3383|UniProtKB=P20651	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	IDA	7532676	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00059	p53 pathway	P01486	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00779	TBP	METAC|EnsemblGenome=MA_0179|UniProtKB=Q8TU94	TATA-box-binding protein 2	IPI	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	RAT|RGD=1309504|UniProtKB=D3ZRN3	Protein Actbl2	ISS	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P02787	Vitamin B6 metabolism	P03227	Phosphoserine transaminase	MACMU|Ensembl=ENSMMUG00000011868|UniProtKB=F7H2J8	Phosphoserine aminotransferase	ISS	2682527	PubMed	PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=98328|UniProtKB=P30875	Somatostatin receptor type 2	ISS	12562507	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P02769	Purine metabolism	P03115	Nucleoside Phosphorylase	MOUSE|MGI=MGI=3712328|UniProtKB=Q9D8C9	Purine nucleoside phosphorylase	ISS	7903568	PubMed	PTHR11904:SF12	PURINE NUCLEOSIDE PHOSPHORYLASE
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	BOVIN|Ensembl=ENSBTAG00000008059|UniProtKB=P41984	Muscarinic acetylcholine receptor M3	ISS	12915051	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P05913	Enkephalin release	P05972	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00757	beta-arrestin	MACMU|Ensembl=ENSMMUG00000023359|UniProtKB=F7E8B5	Uncharacterized protein	ISS	11742073	PubMed	PTHR11792:SF15	S-ARRESTIN
P06664	Gonadotropin-releasing hormone receptor pathway	P06815	12-LO	MOUSE|MGI=MGI=87997|UniProtKB=P39654	Arachidonate 15-lipoxygenase	RCA	12432925	PubMed	PTHR11771:SF33	ARACHIDONATE 15-LIPOXYGENASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06768	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	RCA	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00079	alpha7 nicotinic acetylcholine receptor	CAEBR|Gene=CBG12686|UniProtKB=A8XGC4	Protein CBR-ACR-11	ISS			PTHR18945:SF436	ACETYLCHOLINE RECEPTOR
P00005	Angiogenesis	P00199	JNKK1	HUMAN|HGNC=6844|UniProtKB=P45985	Dual specificity mitogen-activated protein kinase kinase 4	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00036	Interleukin signaling pathway	P00970	Interleukin	HUMAN|HGNC=5986|UniProtKB=Q14116	Interleukin-18	ISS	11331040	PubMed	PTHR45200:SF1	INTERLEUKIN-18
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00006	Apoptosis signaling pathway	P00265	Granzyme B	HUMAN|HGNC=4709|UniProtKB=P10144	Granzyme B	ISS			PTHR24271:SF41	GRANZYME B
P00053	T cell activation	P01324	rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12912997	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00021	FGF signaling pathway	P00623	FGF	BOVIN|Ensembl=ENSBTAG00000017348|UniProtKB=A0MTF4	Fibroblast growth factor 5	ISS			PTHR11486:SF23	FIBROBLAST GROWTH FACTOR 5
P00053	T cell activation	P01298	NFkappaB	RAT|RGD=1307189|UniProtKB=Q5U2Z4	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	ISS	12574369	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00029	Huntington disease	P00788	Calpain	HUMAN|HGNC=16371|UniProtKB=Q96L46	Calpain small subunit 2	IDA	11675509	PubMed	PTHR44408:SF1	CALPAIN SMALL SUBUNIT 2
P00004	Alzheimer disease-presenilin pathway	P00141	Membrane metalloprotease	HUMAN|HGNC=14246|UniProtKB=Q9NPA2	Matrix metalloproteinase-25	RCA			PTHR10201:SF142	MATRIX METALLOPROTEINASE-25
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P02788	Xanthine and guanine salvage pathway	P03245	Guanine phosphoribosyl transferase	BOVIN|Ensembl=ENSBTAG00000014685|UniProtKB=Q3SZ18	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF6	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE
P02775	Salvage pyrimidine ribonucleotides	P03153	Cytidylate kinase	MOUSE|MGI=MGI=1916120|UniProtKB=Q32M07	Adenylate kinase 8	ISS			PTHR23359:SF102	ADENYLATE KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00859	NFkappaB	PANTR|Ensembl=ENSPTRG00000003889|UniProtKB=G2HHW9	Transcription factor p65	RCA			PTHR24169:SF1	TRANSCRIPTION FACTOR P65
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	MOUSE|MGI=MGI=1913714|UniProtKB=Q8VE65	Transcription initiation factor TFIID subunit 12	ISS			PTHR12264:SF21	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00021	FGF signaling pathway	P00644	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01444	Wnt	CHICK|Gene=WNT2B|UniProtKB=Q98SN7	Protein Wnt-2b	IDA	8717036	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	DROME|FlyBase=FBgn0260964|UniProtKB=Q8IH57	GH10249p	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00183	Shc	MOUSE|MGI=MGI=98296|UniProtKB=P98083	SHC-transforming protein 1	ISS	8264585	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00010	B cell activation	P00384	p38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	IDA	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MOUSE|MGI=MGI=1926235|UniProtKB=Q9JKK1	Syntaxin-6	ISS	10839363	PubMed	PTHR19957:SF104	SYNTAXIN-6
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	BOVIN|Ensembl=ENSBTAG00000016187|UniProtKB=F1N213	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	PANTR|Ensembl=ENSPTRG00000005015|UniProtKB=H2Q624	Anti-Muellerian hormone type-2 receptor	ISS	9395284	PubMed	PTHR23255:SF49	ANTI-MUELLERIAN HORMONE TYPE-2 RECEPTOR
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MONDO|Ensembl=ENSMODG00000004799|UniProtKB=F6VM87	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00049	Parkinson disease	P01222	Ubc6	MONDO|Ensembl=ENSMODG00000016452|UniProtKB=F7A451	Uncharacterized protein	ISS	12859888	PubMed	PTHR43972:SF1	UBIQUITIN-CONJUGATING ENZYME E2 J2
P00046	Oxidative stress response	P01129	JNK1/2	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	TAS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	CAEEL|WormBase=WBGene00004769|UniProtKB=P52166	Presenilin sel-12	TAS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00009	Axon guidance mediated by netrin	P00363	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	IDA	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00023	General transcription regulation	P00664	TFIIH complex	BOVIN|Gene=GTF2H3|UniProtKB=Q05B56	General transcription factor IIH subunit 3	ISS			PTHR12831:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	TAKRU|Ensembl=ENSTRUG00000005494|UniProtKB=P53483	Actin, alpha anomalous	IDA	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00591	PLCbeta	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04393	Ras Pathway	P04557	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DROME|FlyBase=FBgn0030011|UniProtKB=Q9W3J1	Gbeta5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000008714|UniProtKB=F7E1N0	Adenosine receptor A1	ISS	12515326	PubMed	PTHR24246:SF1	ADENOSINE RECEPTOR A1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	XENTR|Ensembl=ENSXETG00000030140|UniProtKB=F7EP58	Uncharacterized protein (Fragment)	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P06587	Nicotine pharmacodynamics pathway	P06594	CHRNA4	HUMAN|HGNC=1958|UniProtKB=P43681	Neuronal acetylcholine receptor subunit alpha-4	TAS	85270494	PubMed	PTHR18945:SF401	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00059	p53 pathway	P04611	P300	HUMAN|HGNC=3373|UniProtKB=Q09472	Histone acetyltransferase p300	ISS	10823891	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	BOVIN|Ensembl=ENSBTAG00000047202|UniProtKB=G3N3K3	Uncharacterized protein	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00059	p53 pathway	P01486	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000022548|UniProtKB=F6Y9J9	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	ORNAN|Ensembl=ENSOANG00000010302|UniProtKB=F6TDQ6	Uncharacterized protein	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00056	VEGF signaling pathway	P01417	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	BOVIN|Ensembl=ENSBTAG00000010191|UniProtKB=Q08E52	Serine/threonine-protein kinase PAK 1	ISS	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00010	B cell activation	P00383	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ORNAN|Ensembl=ENSOANG00000007716|UniProtKB=F6UDX9	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	PANTR|Ensembl=ENSPTRG00000010617|UniProtKB=H2QFL8	Notch 3	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONBE|Gene=37852|UniProtKB=A9V489	Predicted protein	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02774	Salvage pyrimidine deoxyribonucleotides	P03148	Thymidine phosphorylase	STRCO|Gene=CAC33055|UniProtKB=Q9AK36	Thymidine phosphorylase	ISS	12000953	PubMed	PTHR10515:SF0	THYMIDINE PHOSPHORYLASE
P02736	Coenzyme A biosynthesis	P02884	Dephospho-CoA kinase	MACMU|Ensembl=ENSMMUG00000004066|UniProtKB=F6ZK89	Dephospho-CoA kinase domain-containing protein	ISS			PTHR10695:SF35	DEPHOSPHO-COA KINASE DOMAIN-CONTAINING PROTEIN
P00059	p53 pathway	P04609	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	10799299	PubMed	PTHR10048:SF14	PI-3 KINASE
P00006	Apoptosis signaling pathway	P00310	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	ARATH|TAIR=AT2G29900|UniProtKB=Q9SIK7	Presenilin-like protein At2g29900	TAS	8755489	PubMed	PTHR10202:SF22	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00561	STAT	RAT|RGD=3772|UniProtKB=P52631	Signal transducer and activator of transcription 3	IGI	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4401|UniProtKB=O14775	Guanine nucleotide-binding protein subunit beta-5	IC	9754712	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00018	EGF receptor signaling pathway	P00562	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IGI	12810719	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00030	Hypoxia response via HIF activation	P00819	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00057	Wnt signaling pathway	P01447	Dishevelled	MONDO|Ensembl=ENSMODG00000003229|UniProtKB=F6TYA8	Uncharacterized protein (Fragment)	ISS	11212302	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	RCA			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	TAS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P02747	Histidine biosynthesis	P02993	Phosphoribosylformimino-5-amino-1-phosphoribosyl-4 imadazol carboxamide isomerase	RHOBA|EnsemblGenome=RB8080|UniProtKB=Q7UG70	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase	ISS			PTHR43090:SF2	1- 5-PHOSPHORIBOSYL -5-  5-PHOSPHORIBOSYLAMINO METHYLIDENEAMINO  IMIDAZOLE-4-CARBOXAMIDE ISOMERASE
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00638	PLCgamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	DAPPU|EnsemblGenome=DAPPUDRAFT_306746|UniProtKB=E9GYE9	Putative uncharacterized protein	ISS	4757952	gi	PTHR24072:SF192	CDC42 HOMOLOG
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00004	Alzheimer disease-presenilin pathway	P00125	Ire-1 C-terminal fragment	CANLF|Ensembl=ENSCAFG00000011784|UniProtKB=F1P7G9	Uncharacterized protein	ISS	10619423	PubMed	PTHR13954:SF17	SERINE/THREONINE-PROTEIN KINASE/ENDORIBONUCLEASE IRE1
P00029	Huntington disease	P00799	JNK-2	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	MONDO|Ensembl=ENSMODG00000019523|UniProtKB=F6VCI6	Uncharacterized protein	ISS	10806215	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04398	p53 pathway feedback loops 2	P04665	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	IC	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00053	T cell activation	P01300	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04566	Stat 1/3	HUMAN|HGNC=11362|UniProtKB=P42224	Signal transducer and activator of transcription 1-alpha/beta	IDA	10207096	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P02751	Lysine biosynthesis	P03006	Dihydrodipicolinate  reductase	ARATH|TAIR=AT2G44040|UniProtKB=O80574	4-hydroxy-tetrahydrodipicolinate reductase 1, chloroplastic	ISS			PTHR20836:SF4	4-HYDROXY-TETRAHYDRODIPICOLINATE REDUCTASE 1, CHLOROPLASTIC-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	BOVIN|Ensembl=ENSBTAG00000002625|UniProtKB=A2VDU3	Mitogen-activated protein kinase kinase kinase 7	ISS	10683140	PubMed	PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P00024	Glycolysis	P00678	Enolase	MOUSE|MGI=MGI=95394|UniProtKB=P17183	Gamma-enolase	ISS	86042683	PubMed	PTHR11902:SF10	GAMMA-ENOLASE
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MOUSE|MGI=MGI=1346876|UniProtKB=O35099	Mitogen-activated protein kinase kinase kinase 5	ISS	12968034	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00045	Notch signaling pathway	P01101	Su(H)	PANTR|Ensembl=ENSPTRG00000015968|UniProtKB=H2R2Q6	Uncharacterized protein	ISS	12145413	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00005	Angiogenesis	P00251	cPLA2	MONDO|Ensembl=ENSMODG00000011791|UniProtKB=F7CBU9	Phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00048	PI3 kinase pathway	P01181	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05913	Enkephalin release	P05972	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00924	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01443	Phospholipase C	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00021	FGF signaling pathway	P00624	14-3-3	MOUSE|MGI=MGI=1891917|UniProtKB=Q9CQV8	14-3-3 protein beta/alpha	ISS	91108808	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	RAT|RGD=1304887|UniProtKB=D3ZPL7	Down syndrome cell adhesion molecule-like 1 (Predicted)	ISS			PTHR44107:SF3	DOWN SYNDROME CELL ADHESION MOLECULE-LIKE PROTEIN 1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05734	Synaptic vesicle trafficking	P05774	NSF	PANTR|Ensembl=ENSPTRG00000009320|UniProtKB=H2QD95	N-ethylmaleimide-sensitive factor	ISS	7969419	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00007	Axon guidance mediated by semaphorins	P00340	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	PANTR|Ensembl=ENSPTRG00000004718|UniProtKB=H2Q5I0	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00046	Oxidative stress response	P01129	JNK1/2	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00049	Parkinson disease	P01208	Hsp70	MACMU|Ensembl=ENSMMUG00000004696|UniProtKB=F6RLH5	Heat shock cognate 71 kDa protein isoform 1	ISS	12150907	PubMed	PTHR19375:SF239	HEAT SHOCK COGNATE 71 KDA PROTEIN
P00036	Interleukin signaling pathway	P00996	STAT	MOUSE|MGI=MGI=103038|UniProtKB=P42227	Signal transducer and activator of transcription 3	IC	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00021	FGF signaling pathway	P00627	ERK1-2	ARATH|TAIR=AT2G18170|UniProtKB=Q39027	Mitogen-activated protein kinase 7	ISS			PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P00012	Cadherin signaling pathway	P00477	GSK3beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04393	Ras Pathway	P04556	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01369	MKK1	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04395	Vasopressin synthesis	P04589	Signal Peptidase	BOVIN|Ensembl=ENSBTAG00000011239|UniProtKB=P67810	Signal peptidase complex catalytic subunit SEC11A	ISS	2092035	PubMed	PTHR10806:SF8	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11A-RELATED
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IDA	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00037	Ionotropic glutamate receptor pathway	P01026	KA	PANTR|Ensembl=ENSPTRG00000018449|UniProtKB=H2QTG5	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00055	Transcription regulation by bZIP transcription factor	P01395	TFIIE	CAEEL|WormBase=WBGene00013998|UniProtKB=G5EG49	TFIIE-alpha protein	ISS			PTHR13097:SF7	NOVEL PROTEIN SIMILAR TO VERTEBRATE GENERAL TRANSCRIPTION FACTOR IIE POLYPEPTIDE 1 ALPHA 56KDA  GTF2E1
P02775	Salvage pyrimidine ribonucleotides	P03149	Cytidine kinase	PANTR|Ensembl=ENSPTRG00000001619|UniProtKB=H2Q0I7	Uridine-cytidine kinase	ISS			PTHR10285:SF70	URIDINE-CYTIDINE KINASE 2
P00034	Integrin signalling pathway	P00925	MEK	PANTR|Ensembl=ENSPTRG00000008783|UniProtKB=H2QCA7	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00006	Apoptosis signaling pathway	P00318	PKCs	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00024	Glycolysis	P00671	Phosphoglycerate kinase	NEUCR|EnsemblGenome=EFNCRG00000008198|UniProtKB=P38667	Phosphoglycerate kinase	IDA	92329982	PubMed	PTHR11406:SF0	PHOSPHOGLYCERATE KINASE
P00057	Wnt signaling pathway	P01438	PP2A	HUMAN|HGNC=9313|UniProtKB=Q16537	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	IDA	8703017	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CAEEL|WormBase=WBGene00000065|UniProtKB=P0DM42	Actin-3	IC	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00019	Endothelin signaling pathway	P00589	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01417	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	MACMU|Ensembl=ENSMMUG00000012305|UniProtKB=F7DLC9	Tyrosine-protein kinase receptor	ISS	11182407	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00035	Interferon-gamma signaling pathway	P00960	PTP	BOVIN|Ensembl=ENSBTAG00000002048|UniProtKB=F1N339	Tyrosine-protein phosphatase non-receptor type	ISS	14534538	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00056	VEGF signaling pathway	P01408	Akt/PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00251	cPLA2	CHICK|Ensembl=ENSGALG00000005065|UniProtKB=P49147	Cytosolic phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00552	Ras	CHICK|Ensembl=ENSGALG00000005998|UniProtKB=Q5ZIW8	Uncharacterized protein	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00019	Endothelin signaling pathway	P00591	PLCbeta	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00637	MKK4,7	MACMU|Ensembl=ENSMMUG00000019842|UniProtKB=F7FU91	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	IDA	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00021	FGF signaling pathway	P00640	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	MONDO|Ensembl=ENSMODG00000006553|UniProtKB=F7BUW7	Uncharacterized protein	ISS	10409711	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P00019	Endothelin signaling pathway	P00586	Gq	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00017	DNA replication	P00536	DNA Topisomerase	CANLF|Ensembl=ENSCAFG00000005702|UniProtKB=F1PRA7	DNA topoisomerase 2	ISS			PTHR10169:SF36	DNA TOPOISOMERASE 2-BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IDA	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00018	EGF receptor signaling pathway	P00545	JNK1-3	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=87934|UniProtKB=Q01338	Alpha-2A adrenergic receptor	IDA	11781138	PubMed	PTHR24248:SF24	ALPHA-2A ADRENERGIC RECEPTOR
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_126324|UniProtKB=C3XYC2	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MACMU|Ensembl=ENSMMUG00000015709|UniProtKB=F6SLX4	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00034	Integrin signalling pathway	P00935	ILK	MACMU|Ensembl=ENSMMUG00000007741|UniProtKB=F7C2W0	Integrin-linked protein kinase	ISS			PTHR44344:SF1	INTEGRIN-LINKED PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01284	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS			PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00049	Parkinson disease	P01208	Hsp70	YEAST|SGD=S000000171|UniProtKB=P09435	Heat shock protein SSA3	IDA	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00029	Huntington disease	P00796	Kainate receptor	CHICK|Ensembl=ENSGALG00000015434|UniProtKB=F1NU20	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00035	Interferon-gamma signaling pathway	P00956	SOCS	BOVIN|Ensembl=ENSBTAG00000012007|UniProtKB=Q861R0	Suppressor of cytokine signaling 2	ISS	15032587	PubMed	PTHR44396:SF2	SUPPRESSOR OF CYTOKINE SIGNALING 2
P05917	Opioid proopiomelanocortin pathway	P06011	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00057	Wnt signaling pathway	P01465	Ggamma	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P05915	Opioid proenkephalin pathway	P05994	G-protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05915	Opioid proenkephalin pathway	P05994	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	PANTR|Ensembl=ENSPTRG00000001477|UniProtKB=H2Q0A5	Tyrosine-protein kinase receptor	ISS	12644000	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P02723	Adenine and hypoxanthine salvage pathway	P02811	Adenosine deaminase	PSEAE|EnsemblGenome=PA0148|UniProtKB=Q9I6Y4	Adenine deaminase	ISS			PTHR43114:SF2	ADENINE DEAMINASE
P00055	Transcription regulation by bZIP transcription factor	P01392	TFIIH complex	MOUSE|MGI=MGI=1277216|UniProtKB=Q9DBA9	General transcription factor IIH subunit 1	ISS			PTHR12856:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 1
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	PANTR|Ensembl=ENSPTRG00000004233|UniProtKB=H2Q4N9	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00006	Apoptosis signaling pathway	P00327	FADD	PANTR|Ensembl=ENSPTRG00000004004|UniProtKB=H2Q4B6	FAS-associated death domain protein	ISS	9506948	PubMed	PTHR15077:SF8	FAS-ASSOCIATED DEATH DOMAIN PROTEIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	DANRE|ZFIN=ZDB-GENE-031222-4|UniProtKB=Q6P0S4	Uncharacterized protein	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00006	Apoptosis signaling pathway	P00260	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IDA	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00626	Spry	CANLF|Ensembl=ENSCAFG00000006250|UniProtKB=F1Q4C2	Uncharacterized protein	ISS	22024232	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00029	Huntington disease	P00812	Caspase 3	RAT|RGD=2275|UniProtKB=P55213	Caspase-3	IDA	9323209	PubMed	PTHR10454:SF198	CASPASE-3
P00018	EGF receptor signaling pathway	P00556	PLCgamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IGI	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04395	Vasopressin synthesis	P04590	Vasopressin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00036	Interleukin signaling pathway	P00966	mTOR	MONDO|Ensembl=ENSMODG00000011138|UniProtKB=F7BA89	Uncharacterized protein	ISS	8662507	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00010	B cell activation	P00383	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00790	beta-Tubulin	TAKRU|Ensembl=ENSTRUG00000000002|UniProtKB=H2RIN9	Uncharacterized protein	ISS			PTHR11588:SF236	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IPI	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00006	Apoptosis signaling pathway	P00269	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANAL|CGD=CAL0006065|UniProtKB=Q59LC4	Phosphoinositide phospholipase C	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MACMU|Ensembl=ENSMMUG00000016675|UniProtKB=F6VTB5	Uncharacterized protein	ISS	11554554	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	TAS	12736250	PubMed	PTHR10202:SF18	PRESENILIN-1
P00005	Angiogenesis	P00203	Erk	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CANLF|Ensembl=ENSCAFG00000005662|UniProtKB=E2R907	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00009	Axon guidance mediated by netrin	P00366	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00006	Apoptosis signaling pathway	P00310	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	MACMU|Ensembl=ENSMMUG00000011231|UniProtKB=F6WXV4	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P04393	Ras Pathway	P04570	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00182	p38MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02740	De novo pyrimidine ribonucleotides biosythesis	P02926	Aspartate carbamoyltransferase	PYRAE|EnsemblGenome=PAE0770|UniProtKB=Q8ZYH7	Aspartate carbamoyltransferase	ISS			PTHR11405:SF16	ASPARTATE CARBAMOYLTRANSFERASE, CHLOROPLASTIC
P00006	Apoptosis signaling pathway	P00310	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01162	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00049	Parkinson disease	P01232	CASK	XENTR|Xenbase=XB-GENE-1014725|UniProtKB=F6UGQ3	Uncharacterized protein	ISS	11430913	PubMed	PTHR23122:SF40	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04393	Ras Pathway	P04543	MEKK1/4	CANLF|Ensembl=ENSCAFG00000000760|UniProtKB=E2R9L4	Uncharacterized protein	ISS	9305639	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02916	dTMP kinase	METJA|EnsemblGenome=MJ_0293|UniProtKB=Q57741	Probable thymidylate kinase	ISS			PTHR10344:SF1	THYMIDYLATE KINASE
P00056	VEGF signaling pathway	P01412	HSP27	MOUSE|MGI=MGI=88516|UniProtKB=P23927	Alpha-crystallin B chain	ISS			PTHR11527:SF37	ALPHA-CRYSTALLIN B CHAIN
P00048	PI3 kinase pathway	P01178	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12186904	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P05918	p38 MAPK pathway	P06031	p38alpha	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	ENTHI|Gene=EHI_112050|UniProtKB=C4M7H7	TATA-box-binding protein 2	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	92020947	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	ISS	11319238	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00006	Apoptosis signaling pathway	P00273	p53	MOUSE|MGI=MGI=98834|UniProtKB=P02340	Cellular tumor antigen p53	ISS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	BOVIN|Ensembl=ENSBTAG00000011803|UniProtKB=F1MTZ2	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF427	MYOSIN-3
P00005	Angiogenesis	P00252	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00029	Huntington disease	P00796	Kainate receptor	PANTR|Ensembl=ENSPTRG00000000543|UniProtKB=H2PYN8	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00021	FGF signaling pathway	P00638	PLCgamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00048	PI3 kinase pathway	P01177	P110ACT	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	HUMAN|HGNC=5302|UniProtKB=P34969	5-hydroxytryptamine receptor 7	IDA	12441358	PubMed	PTHR24247:SF116	5-HYDROXYTRYPTAMINE RECEPTOR 7
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00228	Grb7	PANTR|Ensembl=ENSPTRG00000009102|UniProtKB=H2QCV3	Uncharacterized protein	ISS	10521483	PubMed	PTHR11243:SF25	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00866	Cytokine receptor	MOUSE|MGI=MGI=107654|UniProtKB=Q63953	Ifngr2 protein	IDA	10679118	PubMed	PTHR20859:SF46	INTERFERON GAMMA RECEPTOR 2
P00034	Integrin signalling pathway	P00907	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05934	ELK1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	RCA	11050086	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P02757	O-antigen biosynthesis	P03045	dTDP-glucose 4,6-dehydratase	HUMAN|HGNC=20324|UniProtKB=O95455	dTDP-D-glucose 4,6-dehydratase	ISS			PTHR43000:SF7	DTDP-D-GLUCOSE 4,6-DEHYDRATASE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05918	p38 MAPK pathway	P06026	MEKK4	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02738	De novo purine biosynthesis	P02909	GDP reductase	HALSA|EnsemblGenome=VNG_2384G|UniProtKB=Q9HMU3	Ribonucleoside reductase large chain	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	RAT|RGD=3100|UniProtKB=P50280	Matrilysin	IEP	12834808	PubMed	PTHR10201:SF143	MATRILYSIN
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	XENTR|Xenbase=XB-GENE-479567|UniProtKB=A4ZGP0	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P00010	B cell activation	P00383	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CANLF|Ensembl=ENSCAFG00000010210|UniProtKB=P61162	Alpha-centractin	ISS	14684598	PubMed	PTHR11937:SF46	ALPHA-CENTRACTIN
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00049	Parkinson disease	P01213	Cyclin E	HUMAN|HGNC=1589|UniProtKB=P24864	G1/S-specific cyclin-E1	IDA	12628165	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00047	PDGF signaling pathway	P01174	Rho	ORNAN|Ensembl=ENSOANG00000014039|UniProtKB=F6Q8Z8	Uncharacterized protein	ISS			PTHR15377:SF4	RHO GTPASE-ACTIVATING PROTEIN 5
P00059	p53 pathway	G04694	p110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00006	Apoptosis signaling pathway	P00269	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00001	Adrenaline and noradrenaline biosynthesis	P00070	VAT2	MOUSE|MGI=MGI=106677|UniProtKB=Q8BRU6	Synaptic vesicular amine transporter	IC	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00030	Hypoxia response via HIF activation	P00814	P300	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	NEUCR|EnsemblGenome=EFNCRG00000003893|UniProtKB=P78711	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00005	Angiogenesis	P00238	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00005	Angiogenesis	P00187	beta catenin	TAKRU|Ensembl=ENSTRUG00000003520|UniProtKB=H2S791	Uncharacterized protein	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00010	B cell activation	P00372	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	9763606	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00029	Huntington disease	P00780	Microtubule	DROME|FlyBase=FBgn0003889|UniProtKB=P61857	Tubulin beta-2 chain	IDA	12932731	PubMed	PTHR11588:SF155	TUBULIN BETA-2 CHAIN
P00010	B cell activation	P00375	Calmodulin	ORYSJ|EnsemblGenome=OS01G0267900|UniProtKB=Q0JNS6	Calmodulin-1	ISS	10487978	PubMed	PTHR23050:SF245	AT16150P-RELATED
P02738	De novo purine biosynthesis	P02902	ADP reductase	YEAST|SGD=S000001328|UniProtKB=P21672	Ribonucleoside-diphosphate reductase large chain 2	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00005	Angiogenesis	P00238	Ras	BOVIN|Ensembl=ENSBTAG00000009778|UniProtKB=E1BMX0	Uncharacterized protein	ISS	9869449	PubMed	PTHR24070:SF186	GTPASE KRAS
P00054	Toll receptor signaling pathway	P01350	TIRAP	MOUSE|MGI=MGI=2152213|UniProtKB=Q99JY1	Toll/interleukin-1 receptor domain-containing adapter protein	IDA	21417617	PubMed	PTHR22662:SF0	TOLL/INTERLEUKIN-1 RECEPTOR DOMAIN-CONTAINING ADAPTER PROTEIN
P00054	Toll receptor signaling pathway	P01375	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	IDA	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00052	TGF-beta signaling pathway	P01275	P38	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	TAS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00053	T cell activation	P01315	Calcineurin	PANTR|Ensembl=ENSPTRG00000016315|UniProtKB=H2QPY6	Serine/threonine-protein phosphatase	ISS	7532676	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P05913	Enkephalin release	P05972	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00951	Jnk	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00056	VEGF signaling pathway	P01411	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00047	PDGF signaling pathway	P01143	ERK	DICDI|dictyBase=DDB_G0283903|UniProtKB=Q54QB1	Extracellular signal-regulated kinase 2	ISS	95146547	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00029	Huntington disease	P00805	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IDA	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00560	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01275	P38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	TAS	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	BOVIN|Ensembl=ENSBTAG00000010740|UniProtKB=P04975	Clathrin light chain B	ISS	11889126	PubMed	PTHR10639:SF2	CLATHRIN LIGHT CHAIN B
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00006	Apoptosis signaling pathway	P00310	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00019	Endothelin signaling pathway	P00590	IP3 R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=12781|UniProtKB=Q93097	Protein Wnt-2b	IDA	8717036	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P05912	Dopamine receptor mediated signaling pathway	P05961	DOPA decarb.	DROME|FlyBase=FBgn0000422|UniProtKB=P05031	Aromatic-L-amino-acid decarboxylase	ISS	7567987	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00012	Cadherin signaling pathway	P00468	Src	CHICK|Ensembl=ENSGALG00000003855|UniProtKB=P00523	Proto-oncogene tyrosine-protein kinase Src	ISS	11078745	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00049	Parkinson disease	P01233	Elk-1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	IDA	11050086	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P06664	Gonadotropin-releasing hormone receptor pathway	P06778	TGFbeta	MOUSE|MGI=MGI=98725|UniProtKB=P04202	Transforming growth factor beta-1	RCA	9759503	PubMed	PTHR11848:SF125	TRANSFORMING GROWTH FACTOR BETA-1
P05918	p38 MAPK pathway	P06025	SRF	MACMU|Ensembl=ENSMMUG00000000033|UniProtKB=F7G4D2	Uncharacterized protein	ISS	15326221	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	CAEBR|Gene=CBG02059|UniProtKB=A8WRW6	Protein CBR-UNC-2 (Fragment)	ISS	8386525	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00578	eNOS	CANLF|Gene=NOS3|UniProtKB=Q9TUX8	Nitric oxide synthase, endothelial	ISS	93055452	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00013	Cell cycle	P00481	APC	YEAST|SGD=S000004117|UniProtKB=Q12440	Anaphase-promoting complex subunit 2	ISS	97002444	PubMed	PTHR11932:SF5	ANAPHASE-PROMOTING COMPLEX SUBUNIT 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	BOVIN|Gene=CHRNB4|UniProtKB=Q8SPU6	Neuronal acetylcholine receptor subunit beta-4	IC	22213672	PubMed	PTHR18945:SF385	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-4
P00057	Wnt signaling pathway	P01472	Histone deacetylase	PANTR|Ensembl=ENSPTRG00000017348|UniProtKB=H2QRN6	Histone deacetylase	ISS	10485845	PubMed	PTHR10625:SF132	HISTONE DEACETYLASE 3
P00012	Cadherin signaling pathway	P00470	F-actin	CANLF|Ensembl=ENSCAFG00000012181|UniProtKB=F2Z4N7	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	RAT|RGD=1586637|UniProtKB=F1LMY4	Ryanodine receptor 1	ISS	8930069	PubMed	PTHR13715:SF15	RYANODINE RECEPTOR 1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04398	p53 pathway feedback loops 2	P04658	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00010	B cell activation	P00384	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8696|UniProtKB=Q9Y5H4	Protocadherin gamma-A1	IDA	8120095	PubMed	PTHR24028:SF108	PROTOCADHERIN GAMMA-A1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	15313841	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00053	T cell activation	P01324	rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00053	T cell activation	P01312	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00045	Notch signaling pathway	P01103	Next	MOUSE|MGI=MGI=99460|UniProtKB=Q61982	Neurogenic locus notch homolog protein 3	IC	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00053	T cell activation	P01294	NFAT	RAT|RGD=1308692|UniProtKB=A0A0G2JTY4	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 (Predicted), isoform CRA_b	ISS	12015605	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P05913	Enkephalin release	P05974	G-Protein (i)	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00542	EGFR	HUMAN|HGNC=3431|UniProtKB=P21860	Receptor tyrosine-protein kinase erbB-3	ISS	17432904	gi	PTHR24416:SF88	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3
P00057	Wnt signaling pathway	P01472	Histone deacetylase	MOUSE|MGI=MGI=1097691|UniProtKB=P70288	Histone deacetylase 2	IDA	10485845	PubMed	PTHR10625:SF171	HISTONE DEACETYLASE 2
P00029	Huntington disease	P00774	Dynein complex	MACMU|Ensembl=ENSMMUG00000020974|UniProtKB=F7H0G5	Uncharacterized protein	ISS	9454836	PubMed	PTHR12442:SF7	DYNEIN INTERMEDIATE CHAIN 2, AXONEMAL
P00047	PDGF signaling pathway	P01174	Rho	CHICK|Ensembl=ENSGALG00000007380|UniProtKB=Q5ZMW5	Rho GTPase-activating protein 26	ISS	8649427	PubMed	PTHR12552:SF4	RHO GTPASE-ACTIVATING PROTEIN 26
P00019	Endothelin signaling pathway	P00589	Akt	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	IGI	95181376	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06847	JNK1/2	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	RCA	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00545	JNK1-3	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00564	Rac	MACMU|Ensembl=ENSMMUG00000021075|UniProtKB=F7GY91	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00059	p53 pathway	P04613	B99	MACMU|Ensembl=ENSMMUG00000008136|UniProtKB=F7HGK9	Uncharacterized protein	ISS	20127556	gi	PTHR21584:SF10	G2 AND S PHASE-EXPRESSED PROTEIN 1
P04397	p53 pathway by glucose deprivation	P04636	S6K	HUMAN|HGNC=10436|UniProtKB=P23443	Ribosomal protein S6 kinase beta-1	IDA	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	LEIMA|EnsemblGenome=LmjF.35.4010|UniProtKB=Q9GNR4	Protein kinase A catalytic subunit isoform 1	ISS	14744463	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00020	FAS signaling pathway	P00595	Caspase7	PANTR|Ensembl=ENSPTRG00000002952|UniProtKB=H2Q2L2	Uncharacterized protein	ISS	14583630	PubMed	PTHR10454:SF31	CASPASE-7
P00006	Apoptosis signaling pathway	P00314	MKK3	BOVIN|Ensembl=ENSBTAG00000010576|UniProtKB=A4IFH7	MAP2K3 protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00049	Parkinson disease	P01216	Parkin	HUMAN|HGNC=8607|UniProtKB=O60260	E3 ubiquitin-protein ligase parkin	IDA	11078524	PubMed	PTHR11685:SF214	E3 UBIQUITIN-PROTEIN LIGASE PARKIN
P04393	Ras Pathway	P04552	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	ARATH|TAIR=AT5G07880|UniProtKB=Q9SD96	SNAP25 homologous protein SNAP29	IC			PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00021	FGF signaling pathway	P00625	MKK3,6	MACMU|Ensembl=ENSMMUG00000010904|UniProtKB=F7GLY5	Uncharacterized protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00029	Huntington disease	P00785	Cytochrome c	BRADU|EnsemblGenome=BAC47751|UniProtKB=P51131	Cytochrome b/c1	IDA	9027315	PubMed	PTHR19271:SF5	CYTOCHROME B
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00005	Angiogenesis	P00237	FRP	XENTR|Xenbase=XB-GENE-488230|UniProtKB=F7EN59	Uncharacterized protein (Fragment)	ISS	9096311	PubMed	PTHR11309:SF87	SECRETED FRIZZLED-RELATED PROTEIN 1
P00051	TCA cycle	P01266	Pyruvate Dehydrogenase	BOVIN|Ensembl=ENSBTAG00000008744|UniProtKB=F6Q200	Uncharacterized protein	ISS			PTHR11947:SF15	PYRUVATE DEHYDROGENASE  ACETYL-TRANSFERRING   KINASE ISOZYME 2, MITOCHONDRIAL
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=94925|UniProtKB=P30728	D(3) dopamine receptor	IDA	2137198	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00059	p53 pathway	P04623	CBP	ARATH|TAIR=AT3G12980|UniProtKB=Q9LE42	Histone acetyltransferase HAC5	IDA	10769018	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04397	p53 pathway by glucose deprivation	P04641	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04570	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00907	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02775	Salvage pyrimidine ribonucleotides	P03149	Cytidine kinase	MACMU|Ensembl=ENSMMUG00000015551|UniProtKB=F6RFS7	Uridine-cytidine kinase	ISS			PTHR10285:SF68	URIDINE-CYTIDINE KINASE-LIKE 1
P00053	T cell activation	P01311	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IDA	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00960	PTP	CHICK|Ensembl=ENSGALG00000004821|UniProtKB=Q90687	Tyrosine-protein phosphatase non-receptor type 11	TAS	7681589	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00057	Wnt signaling pathway	P01444	Wnt	MACMU|Ensembl=ENSMMUG00000009980|UniProtKB=F6R3A1	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00018	EGF receptor signaling pathway	P00564	Rac	CHICK|Ensembl=ENSGALG00000002859|UniProtKB=F6UBD2	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04397	p53 pathway by glucose deprivation	P04639	AMPK	CHICK|Ensembl=ENSGALG00000007373|UniProtKB=Q27IP4	5'AMP-activated protein kinase beta-1 non-catalytic subunit	ISS			PTHR10343:SF16	5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00018	EGF receptor signaling pathway	P00556	PLCgamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IGI	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_206575|UniProtKB=E9FUX0	Guanine nucleotide binding protein, beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00048	PI3 kinase pathway	P01177	P110ACT	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00030	Hypoxia response via HIF activation	P00825	Thioredoxin	CAEEL|WormBase=WBGene00015062|UniProtKB=Q09433	Thioredoxin-1	ISS			PTHR10438:SF309	THIOREDOXIN-1
P05731	GABA-B receptor II signaling	P05760	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00034	Integrin signalling pathway	P00906	Rap1	PANTR|Ensembl=ENSPTRG00000005197|UniProtKB=A5A6J7	Ras-related protein Rap-1b	ISS	10476970	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=1305430|UniProtKB=F1M702	Protein Cdh18	ISS	8120095	PubMed	PTHR24027:SF106	CADHERIN-18
P05918	p38 MAPK pathway	P06033	TAB2	BOVIN|Ensembl=ENSBTAG00000013454|UniProtKB=E1B7Z0	Uncharacterized protein	ISS			PTHR10351:SF27	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 2
P00059	p53 pathway	P01486	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	G01535	PIG3	CAEEL|WormBase=WBGene00009554|UniProtKB=O45496	Uncharacterized protein	TAS	12932731	PubMed	PTHR44154:SF1	QUINONE OXIDOREDUCTASE
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	18021322	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	HUMAN|HGNC=29957|UniProtKB=Q96A70	Antizyme inhibitor 2	ISS			PTHR11482:SF4	ANTIZYME INHIBITOR 2
P00049	Parkinson disease	P01238	14-3-3	DANRE|ZFIN=ZDB-GENE-030131-779|UniProtKB=Q7ZW20	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1	ISS	5803225	gi	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P02738	De novo purine biosynthesis	P02909	GDP reductase	PLAF7|EnsemblGenome=PF14_0053|UniProtKB=Q8IM38	Ribonucleotide reductase small subunit	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00057	Wnt signaling pathway	P01465	Ggamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	SCHPO|PomBase=SPAC1556.04c|UniProtKB=Q09190	Putative cytidine deaminase	ISS			PTHR11644:SF2	CYTIDINE DEAMINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	RAT|RGD=2342|UniProtKB=P08482	Muscarinic acetylcholine receptor M1	ISS	10069496	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	SCHPO|PomBase=SPBC337.14|UniProtKB=O74825	DNA-directed RNA polymerase II subunit rpb4	ISS			PTHR21297:SF0	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	BOVIN|Ensembl=ENSBTAG00000047202|UniProtKB=G3N3K3	Uncharacterized protein	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00052	TGF-beta signaling pathway	P01275	P38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00059	p53 pathway	P01486	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02751	Lysine biosynthesis	P03009	Aspartokinase	YEAST|SGD=S000000854|UniProtKB=P10869	Aspartokinase	ISS			PTHR21499:SF3	ASPARTOKINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	STRPU|EnsemblGenome=SPU_009155|UniProtKB=W4Y0D3	Uncharacterized protein	ISS			PTHR23315:SF233	ARMADILLO SEGMENT POLARITY PROTEIN
P00057	Wnt signaling pathway	P01451	Galpha	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	IDA	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04651	Ras	XENTR|Xenbase=XB-GENE-6036229|UniProtKB=Q66JH1	Kras2 protein	ISS			PTHR24070:SF381	SUBFAMILY NOT NAMED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	ORNAN|Ensembl=ENSOANG00000010562|UniProtKB=F6TBG4	Uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00010	B cell activation	P00371	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	CANLF|Ensembl=ENSCAFG00000017575|UniProtKB=Q076A5	Myosin-4	ISS	89264452	PubMed	PTHR13140:SF657	MYOSIN-4
P02750	Lipoate_biosynthesis	P03004	Lipoate synthase	STRCO|EnsemblGenome=CAB90841|UniProtKB=Q9S2P2	Lipoyl synthase	ISS			PTHR10949:SF0	LIPOYL SYNTHASE, MITOCHONDRIAL
P00009	Axon guidance mediated by netrin	P00366	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12912997	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00034	Integrin signalling pathway	P00936	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	IPI	14526383	PubMed	PTHR10048:SF14	PI-3 KINASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06587	Nicotine pharmacodynamics pathway	P06610	CHRNB4	BOVIN|Gene=CHRNB4|UniProtKB=Q8SPU6	Neuronal acetylcholine receptor subunit beta-4	IDA	22213672	PubMed	PTHR18945:SF385	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-4
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	HALSA|EnsemblGenome=VNG_1815G|UniProtKB=Q9HP42	Carbamoyl-phosphate synthase small chain	ISS			PTHR11405:SF4	CARBAMOYL-PHOSPHATE SYNTHASE ARGININE-SPECIFIC SMALL CHAIN
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEEL|WormBase=WBGene00018620|UniProtKB=O44588	Uncharacterized protein	ISS	11880265	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P00010	B cell activation	P00384	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	MOUSE|MGI=MGI=2684058|UniProtKB=Q6SJ95	TATA box-binding protein-like protein 2	ISS	600075	OMIM	PTHR10126:SF33	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 2
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176910	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01284	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05730	Endogenous cannabinoid signaling	P05748	mGluR	RAT|RGD=2742|UniProtKB=P23385	Metabotropic glutamate receptor 1	ISS	7476890	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05731	GABA-B receptor II signaling	P05754	Ggamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	RCA	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04393	Ras Pathway	P04564	MAPKAP	MACMU|Ensembl=ENSMMUG00000023567|UniProtKB=F7HHY8	Uncharacterized protein	ISS	9628873	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00018	EGF receptor signaling pathway	P00551	Akt	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	ISS	12719720	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05731	GABA-B receptor II signaling	P05754	Ggamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00021	FGF signaling pathway	P00624	14-3-3	PANTR|Ensembl=ENSPTRG00000019320|UniProtKB=H2QUT2	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	ISS	10407019	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P05734	Synaptic vesicle trafficking	P05779	Synaptobrevin	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	RCA	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	TAS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	HUMAN|HGNC=4038|UniProtKB=Q9UP38	Frizzled-1	TAS	8717036	PubMed	PTHR11309:SF81	FRIZZLED-1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00545	JNK1-3	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	IC	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05731	GABA-B receptor II signaling	P05755	Gbeta	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02783	Tryptophan biosynthesis	P03210	Indole-3-glycerol phosphate synthase	AQUAE|EnsemblGenome=aq_1787|UniProtKB=O67657	Indole-3-glycerol phosphate synthase	ISS			PTHR22854:SF2	TRYPTOPHAN BIOSYNTHESIS PROTEIN TRPCF
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CANLF|Ensembl=ENSCAFG00000005662|UniProtKB=E2R907	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02787	Vitamin B6 metabolism	P03227	Phosphoserine transaminase	BOVIN|Ensembl=ENSBTAG00000013960|UniProtKB=A6QR28	Phosphoserine aminotransferase	ISS	20886743	gi	PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000000365|UniProtKB=F6R9F4	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00018	EGF receptor signaling pathway	P00559	MEK1-2	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02763	Peptidoglycan biosynthesis	P03086	N-acetylglucosamine-1-phosphate uridyltransferase	PSEAE|EnsemblGenome=PA5552|UniProtKB=Q9HT22	Bifunctional protein GlmU	ISS			PTHR43584:SF3	BIFUNCTIONAL PROTEIN GLMU
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CHICK|Ensembl=ENSGALG00000009287|UniProtKB=O93602	Cyclic AMP-dependent transcription factor ATF-2	TAS	10664585	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01443	Phospholipase C	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00015	Circadian clock system	G01497	cry	MACMU|Ensembl=ENSMMUG00000002453|UniProtKB=F7HH05	Cryptochrome-2	ISS	11533252	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P05913	Enkephalin release	P05971	CREB	MACMU|Ensembl=ENSMMUG00000022508|UniProtKB=F6YPU2	Uncharacterized protein	ISS			PTHR22952:SF97	CAMP-RESPONSIVE ELEMENT MODULATOR
P00054	Toll receptor signaling pathway	P01354	NFkappaB	RAT|RGD=1307189|UniProtKB=Q5U2Z4	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	ISS	9133421	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00052	TGF-beta signaling pathway	P01275	P38	CAEBR|Gene=CBG01555|UniProtKB=A8WRD7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00023	General transcription regulation	P00658	TBP-associated factors	BOVIN|Ensembl=ENSBTAG00000026660|UniProtKB=Q3T174	Transcription initiation factor TFIID subunit 12	ISS			PTHR12264:SF21	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	PANTR|Ensembl=ENSPTRG00000009594|UniProtKB=G2HFH4	Somatostatin receptor type 2	ISS			PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P00053	T cell activation	P01324	rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P02751	Lysine biosynthesis	P03009	Aspartokinase	ARATH|TAIR=AT5G21060|UniProtKB=F4K6Y8	Homoserine dehydrogenase	ISS			PTHR43070:SF4	HOMOSERINE DEHYDROGENASE
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00938	Cdc42	IXOSC|EnsemblGenome=ISCW003614|UniProtKB=B7PHY7	Cdc42 protein, putative	ISS	12932731	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=2652894|UniProtKB=Q80Y86	Mitogen-activated protein kinase 15	ISS	9891064	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_127489|UniProtKB=C3XYC6	Putative uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00047	PDGF signaling pathway	P01153	GSK3	ARATH|TAIR=AT1G06390|UniProtKB=Q39012	Shaggy-related protein kinase iota	ISS	21361340	gi	PTHR24057:SF12	SHAGGY-RELATED PROTEIN KINASE IOTA-RELATED
P00006	Apoptosis signaling pathway	P00269	MAPK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01312	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05915	Opioid proenkephalin pathway	P05994	G-protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P06664	Gonadotropin-releasing hormone receptor pathway	P06726	GC	MOUSE|MGI=MGI=1860604|UniProtKB=O54865	Guanylate cyclase soluble subunit beta-1	RCA			PTHR11920:SF318	GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00036	Interleukin signaling pathway	P00985	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P06664	Gonadotropin-releasing hormone receptor pathway	P06852	nPKCs	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00521	Profilin	MONDO|Ensembl=ENSMODG00000005299|UniProtKB=F7DMM7	Profilin	ISS			PTHR13936:SF14	PROFILIN-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	15470041	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05913	Enkephalin release	P05978	AC	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	HUMAN|HGNC=29846|UniProtKB=O14512	Suppressor of cytokine signaling 7	ISS	12645661	PubMed	PTHR45052:SF1	SUPPRESSOR OF CYTOKINE SIGNALING 7
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	TAKRU|Ensembl=ENSTRUG00000016522|UniProtKB=H2UZ46	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00056	VEGF signaling pathway	P01411	Ras	DICDI|dictyBase=DDB_G0292996|UniProtKB=P03967	Ras-like protein rasD	ISS	6091907	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00049	Parkinson disease	P01230	Src kinase	HUMAN|HGNC=2444|UniProtKB=P41240	Tyrosine-protein kinase CSK	IDA	7687537	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PANTR|Ensembl=ENSPTRG00000008768|UniProtKB=H2QC98	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF368	MYOSIN-8
P00057	Wnt signaling pathway	P01435	SWI/SNF	PANTR|Ensembl=ENSPTRG00000014154|UniProtKB=H2R0D2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	ISS	11532957	PubMed	PTHR10019:SF5	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY B MEMBER 1
P00010	B cell activation	P00402	Jnk	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P06587	Nicotine pharmacodynamics pathway	P06613	CHRNB2	MOUSE|MGI=MGI=87891|UniProtKB=Q9ERK7	Neuronal acetylcholine receptor subunit beta-2	ISS	15155845	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00984	MEK	MOUSE|MGI=MGI=1346875|UniProtKB=O08648	Mitogen-activated protein kinase kinase kinase 4	TAS			PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01289	I-Smads	BOVIN|Ensembl=ENSBTAG00000012441|UniProtKB=E1B8T7	Mothers against decapentaplegic homolog	ISS	9335505	PubMed	PTHR13703:SF27	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 7
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	ARATH|TAIR=AT4G34460|UniProtKB=P49177	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF48	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA
P02783	Tryptophan biosynthesis	P03209	Anthranilate phosphoribosyl transferase	RHOBA|EnsemblGenome=RB3936|UniProtKB=Q7UTD9	Anthranilate synthase component II	ISS			PTHR43418:SF4	MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	MONDO|Ensembl=ENSMODG00000002696|UniProtKB=F7CY56	Uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF335	CALMODULIN, STRIATED MUSCLE
P02738	De novo purine biosynthesis	P02902	ADP reductase	ARATH|TAIR=AT3G23580|UniProtKB=P50651	Ribonucleoside-diphosphate reductase small chain A	ISS			PTHR23409:SF24	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN A
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	RAT|RGD=70513|UniProtKB=P30969	Gonadotropin-releasing hormone receptor	IDA	1333052	PubMed	PTHR24241:SF22	GONADOTROPIN-RELEASING HORMONE RECEPTOR
P00034	Integrin signalling pathway	P00944	Actin	MACMU|Ensembl=ENSMMUG00000012054|UniProtKB=F6TII3	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	CAEEL|WormBase=WBGene00000110|UniProtKB=Q86S57	Aldehyde dehydrogenase	IC			PTHR43570:SF16	ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q
P00004	Alzheimer disease-presenilin pathway	P00125	Ire-1 C-terminal fragment	PANTR|Ensembl=ENSPTRG00000009535|UniProtKB=H2QDP0	Uncharacterized protein	ISS	10619423	PubMed	PTHR13954:SF17	SERINE/THREONINE-PROTEIN KINASE/ENDORIBONUCLEASE IRE1
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00049	Parkinson disease	P01208	Hsp70	PHYPA|Gene=PHYPADRAFT_207434|UniProtKB=A9S0A3	Predicted protein	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DANRE|ZFIN=ZDB-GENE-040426-1354|UniProtKB=Q7T2C5	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00936	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00702	CPB	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	RCA			PTHR13808:SF5	CREB-BINDING PROTEIN
P00016	Cytoskeletal regulation by Rho GTPase	P00507	Rho	PANTR|Ensembl=ENSPTRG00000001112|UniProtKB=H2PZP2	Ras homolog gene family, member C	ISS	12090470	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	MACMU|Ensembl=ENSMMUG00000003145|UniProtKB=F7EPF6	Uncharacterized protein	ISS	2433589	PubMed	PTHR11767:SF52	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 4
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	RCA	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	MACMU|Ensembl=ENSMMUG00000000983|UniProtKB=F6SYL4	Fructose-bisphosphate aldolase	ISS	6086339	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00056	VEGF signaling pathway	P01425	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	10747026	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00010	B cell activation	P00371	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P06587	Nicotine pharmacodynamics pathway	P06608	DDC	HUMAN|HGNC=2719|UniProtKB=P20711	Aromatic-L-amino-acid decarboxylase	TAS	7567987	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00021	FGF signaling pathway	P00645	Rac	DICDI|dictyBase=DDB_G0286555|UniProtKB=P34147	Rho-related protein racA	ISS	12932731	PubMed	PTHR24072:SF183	RHO-RELATED PROTEIN RACA
P00023	General transcription regulation	P00658	TBP-associated factors	BOVIN|Ensembl=ENSBTAG00000000895|UniProtKB=G5E509	Uncharacterized protein	ISS			PTHR12595:SF3	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 9B
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	CHICK|Ensembl=ENSGALG00000012894|UniProtKB=P30372	Muscarinic acetylcholine receptor M2	ISS	11166329	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00049	Parkinson disease	P01238	14-3-3	HUMAN|HGNC=12855|UniProtKB=P63104	14-3-3 protein zeta/delta	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	ISS	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00054	Toll receptor signaling pathway	P01346	TLR	MOUSE|MGI=MGI=2176882|UniProtKB=P58681	Toll-like receptor 7	ISS			PTHR44312:SF1	TOLL-LIKE RECEPTOR 7
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00048	PI3 kinase pathway	P01205	NOS	HUMAN|HGNC=7876|UniProtKB=P29474	Nitric oxide synthase, endothelial	ISS	22462730	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00005	Angiogenesis	P00256	PLC-gamma	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00053	T cell activation	P01300	ERK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	92020947	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=103077|UniProtKB=Q64704	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	XENTR|Xenbase=XB-GENE-493937|UniProtKB=Q5M8T9	Actin, alpha 2, smooth muscle, aorta	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00049	Parkinson disease	P01224	UbcH7	DANRE|ZFIN=ZDB-GENE-030131-2977|UniProtKB=F1QRD9	Uncharacterized protein	ISS			PTHR24068:SF116	AT26201P-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g169611|UniProtKB=A7SEB1	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00018	EGF receptor signaling pathway	P00557	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00022	General transcription by RNA polymerase I	P00652	RNA Polymerase I  Complex	MOUSE|MGI=MGI=108403|UniProtKB=P97304	DNA-directed RNA polymerases I and III subunit RPAC2	IGI	8955128	PubMed	PTHR13946:SF28	DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008422|UniProtKB=F6VUT7	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02752	Mannose metabolism	P03018	Mannose 1-P guanylyl transferase	STRCO|Gene=CAB88884|UniProtKB=Q9KZP4	Putative mannose-1-phosphate guanyltransferase	ISS	12000953	PubMed	PTHR22572:SF124	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P02738	De novo purine biosynthesis	P02908	Phosphoribosylamine glycine ligase	THEMA|EnsemblGenome=TM_1250|UniProtKB=Q9X0X7	Phosphoribosylamine--glycine ligase	ISS			PTHR43472:SF1	PHOSPHORIBOSYLAMINE--GLYCINE LIGASE
P00057	Wnt signaling pathway	P01451	Galpha	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	IDA	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	DROME|FlyBase=FBgn0010399|UniProtKB=Q24418	Glutamate [NMDA] receptor subunit 1	IC	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P05915	Opioid proenkephalin pathway	P05988	peptide E	DANRE|ZFIN=ZDB-GENE-030729-31|UniProtKB=A8E7S2	Uncharacterized protein	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01425	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	15572354	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00049	Parkinson disease	P01240	hSel10	RAT|RGD=2321145|UniProtKB=D3Z902	Protein Fbxw7	RCA			PTHR44007:SF6	F-BOX/WD REPEAT-CONTAINING PROTEIN 7
P00059	p53 pathway	P04616	PDK1/2	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00045	Notch signaling pathway	P01113	Pen-2	XENTR|Xenbase=XB-GENE-854877|UniProtKB=F7C949	Presenilin	ISS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00001	Adrenaline and noradrenaline biosynthesis	P00070	VAT2	RAT|RGD=3694|UniProtKB=Q01827	Synaptic vesicular amine transporter	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00035	Interferon-gamma signaling pathway	P00960	PTP	TAKRU|Ensembl=ENSTRUG00000018529|UniProtKB=H2VDZ2	Tyrosine-protein phosphatase non-receptor type	ISS	8096088	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P06211	BMP/activin signaling pathway-drosophila	P06256	Full-length  BMP orthologous ligand	DROME|FlyBase=FBgn0031461|UniProtKB=Q9VQG9	Dawdle, isoform A	RCA	12537572	PubMed	PTHR11848:SF226	DAWDLE, ISOFORM A
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	IDA	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	TAS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	TAS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00034	Integrin signalling pathway	P00942	Fyn	DANRE|ZFIN=ZDB-GENE-050706-89|UniProtKB=F1RDG9	Tyrosine-protein kinase fynb	ISS	11078745	PubMed	PTHR24418:SF242	TYROSINE-PROTEIN KINASE FYNB
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	89186920	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00001	Adrenaline and noradrenaline biosynthesis	P00061	PNMT	PANTR|Ensembl=ENSPTRG00000019045|UniProtKB=H2QUD4	Uncharacterized protein	ISS			PTHR10867:SF6	INDOLETHYLAMINE N-METHYLTRANSFERASE-RELATED
P00054	Toll receptor signaling pathway	P01375	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00049	Parkinson disease	P01208	Hsp70	PRIPA|Gene=PPA05202|UniProtKB=H3E674	Hsp-1	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000018372|UniProtKB=F7H1J2	Uncharacterized protein	ISS	11259487	PubMed	PTHR24229:SF1	KAPPA-TYPE OPIOID RECEPTOR
P00059	p53 pathway	G04689	Cyclin G	HUMAN|HGNC=1592|UniProtKB=P51959	Cyclin-G1	ISS			PTHR10177:SF59	CYCLIN-G1
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	IXOSC|EnsemblGenome=ISCW020789|UniProtKB=B7PXR7	Putative uncharacterized protein (Fragment)	ISS			PTHR11079:SF149	TRNA-SPECIFIC ADENOSINE DEAMINASE
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	DANRE|ZFIN=ZDB-GENE-030131-8013|UniProtKB=F1QBT6	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	PANTR|Ensembl=ENSPTRG00000009871|UniProtKB=H2QE95	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MACMU|Ensembl=ENSMMUG00000012546|UniProtKB=F7E840	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00035	Interferon-gamma signaling pathway	P00952	Jak2	RAT|RGD=2939|UniProtKB=Q62689	Tyrosine-protein kinase JAK2	TAS	12686512	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P04393	Ras Pathway	P04570	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	MACMU|Ensembl=ENSMMUG00000005362|UniProtKB=F7GAS0	Uncharacterized protein	ISS			PTHR11079:SF92	TRNA-SPECIFIC ADENOSINE DEAMINASE 2
P02788	Xanthine and guanine salvage pathway	P03249	Guanine deaminase	PANTR|Ensembl=ENSPTRG00000021020|UniProtKB=H2R3N5	Uncharacterized protein	ISS	11837778	gi	PTHR11271:SF6	GUANINE DEAMINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	TAS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05916	Opioid prodynorphin pathway	P06002	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	LEIMA|EnsemblGenome=LmjF.35.3960|UniProtKB=E9AFM1	Protein kinase A catalytic subunit isoform 2	IC	14744463	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00257	Bcl-xL	MACMU|Ensembl=ENSMMUG00000005985|UniProtKB=F6UKR4	Bcl-2-like protein 1	ISS	7963517	PubMed	PTHR11256:SF12	BCL-2-LIKE PROTEIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00107	kinesin	RAT|RGD=1307377|UniProtKB=B2GV74	Kinesin light chain 2 (Predicted), isoform CRA_b	ISS	11740561	PubMed	PTHR19959:SF177	KINESIN LIGHT CHAIN 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	ARATH|TAIR=AT1G13890|UniProtKB=Q9LMG8	Putative SNAP25 homologous protein SNAP30	IC			PTHR19305:SF7	SNAP25 HOMOLOGOUS PROTEIN SNAP30-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04380	Cortocotropin releasing factor receptor signaling pathway	G04671	proopiomelanocortin	HUMAN|HGNC=9201|UniProtKB=P01189	Pro-opiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P05730	Endogenous cannabinoid signaling	P05746	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Ensembl=ENSGALG00000028612|UniProtKB=F1P3X1	Uncharacterized protein	IEP	10938134	PubMed	PTHR13140:SF728	MYOSIN HEAVY CHAIN, SKELETAL MUSCLE, ADULT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	BOVIN|Ensembl=ENSBTAG00000011803|UniProtKB=F1MTZ2	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF427	MYOSIN-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	HUMAN|HGNC=4583|UniProtKB=Q16478	Glutamate receptor ionotropic, kainate 5	ISS	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	TAS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05916	Opioid prodynorphin pathway	G06049	preprodynorphin	MOUSE|MGI=MGI=97535|UniProtKB=O35417	Proenkephalin-B	RCA	131330	OMIM	PTHR11438:SF4	PROENKEPHALIN-B
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	BOVIN|Ensembl=ENSBTAG00000013657|UniProtKB=Q8SPU7	Neuronal acetylcholine receptor subunit alpha-5	IC	85270494	PubMed	PTHR18945:SF76	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5
P00019	Endothelin signaling pathway	P00590	IP3 R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00005	Angiogenesis	P00236	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	CANLF|Ensembl=ENSCAFG00000030300|UniProtKB=J9P893	Uncharacterized protein	ISS	10941822	PubMed	PTHR10489:SF635	C-C CHEMOKINE RECEPTOR TYPE 7
P00021	FGF signaling pathway	P00643	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04550	Ral	CHICK|Ensembl=ENSGALG00000012310|UniProtKB=E1C524	Uncharacterized protein	ISS	11025226	PubMed	PTHR24070:SF174	RAS-RELATED PROTEIN RAL-A
P00021	FGF signaling pathway	P00627	ERK1-2	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00005	Angiogenesis	P00220	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P05730	Endogenous cannabinoid signaling	P05751	Galpha	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00049	Parkinson disease	P01236	Casein kinase II	XENTR|Xenbase=XB-GENE-487924|UniProtKB=F6WVD0	Casein kinase II subunit beta (Fragment)	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00025	Hedgehog signaling pathway	P00682	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01465	Ggamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000025373|UniProtKB=F6ZZG9	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00025	Hedgehog signaling pathway	P00682	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00846	JAK	RAT|RGD=2939|UniProtKB=Q62689	Tyrosine-protein kinase JAK2	ISS	22482294	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CHICK|Ensembl=ENSGALG00000028749|UniProtKB=Q5ZMQ2	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00048	PI3 kinase pathway	P01177	P110ACT	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01211	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00047	PDGF signaling pathway	P01161	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	12471242	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	RCA	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	ARATH|TAIR=AT5G04510|UniProtKB=Q9XF67	3-phosphoinositide-dependent protein kinase 1	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06741	NOSI	MOUSE|MGI=MGI=97360|UniProtKB=Q9Z0J4	Nitric oxide synthase, brain	RCA			PTHR19384:SF63	NITRIC OXIDE SYNTHASE, BRAIN
P06959	CCKR signaling map	P07227	KLF4	HUMAN|HGNC=6348|UniProtKB=O43474	Krueppel-like factor 4	RCA	8928792	PubMed	PTHR44778:SF1	KRUEPPEL-LIKE FACTOR 4
P06664	Gonadotropin-releasing hormone receptor pathway	P06732	ATF2	MOUSE|MGI=MGI=109349|UniProtKB=P16951	Cyclic AMP-dependent transcription factor ATF-2	RCA	10664585	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00010	B cell activation	P00391	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00054	Toll receptor signaling pathway	P01368	MKK2	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	RAT|RGD=2845|UniProtKB=P19327	5-hydroxytryptamine receptor 1A	IEA	2156831	PubMed	PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P05731	GABA-B receptor II signaling	P05754	Ggamma	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00021	FGF signaling pathway	P00642	MEK1-2	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00007	Axon guidance mediated by semaphorins	P00328	plexinB1	BOVIN|Ensembl=ENSBTAG00000013407|UniProtKB=E1B7F6	Uncharacterized protein	ISS			PTHR22625:SF36	PLEXIN-B1
P05916	Opioid prodynorphin pathway	P06002	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00005	Angiogenesis	P00203	Erk	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00644	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	XENTR|Xenbase=XB-GENE-977853|UniProtKB=F7EBE7	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00049	Parkinson disease	P01227	20S proteasome	PANTR|Ensembl=ENSPTRG00000013699|UniProtKB=H2QKQ2	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF40	PROTEASOME SUBUNIT ALPHA TYPE-7
P00049	Parkinson disease	P01230	Src kinase	MOUSE|MGI=MGI=95602|UniProtKB=P39688	Tyrosine-protein kinase Fyn	IDA	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00018	EGF receptor signaling pathway	P00547	PP2A	CANLF|Ensembl=ENSCAFG00000001753|UniProtKB=F1P714	Uncharacterized protein	ISS	12110603	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00029	Huntington disease	P00761	Truncated Htt	RAT|RGD=68337|UniProtKB=P51111	Huntingtin	TAS	9462744	PubMed	PTHR10170:SF10	HUNTINGTIN
P00029	Huntington disease	P00786	ARF	MONBE|Gene=35269|UniProtKB=A9V847	Predicted protein	ISS	12932731	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	CHICK|Ensembl=ENSGALG00000011699|UniProtKB=F1NEC3	Uncharacterized protein	IDA	21222856	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00058	mRNA splicing	P01476	U4	YEAST|SGD=S000006382|UniProtKB=P20053	U4/U6 small nuclear ribonucleoprotein PRP4	ISS	97313271	PubMed	PTHR19846:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP4
P00047	PDGF signaling pathway	P01167	Ets	MONDO|Ensembl=ENSMODG00000004730|UniProtKB=F6Y1Z2	Uncharacterized protein	ISS	15699632	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	PYRAE|EnsemblGenome=PAE0974|UniProtKB=Q8ZY26	Adenylosuccinate synthetase	IEP	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MONDO|Ensembl=ENSMODG00000004799|UniProtKB=F6VM87	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ORYSJ|EnsemblGenome=OS12G0163700|UniProtKB=Q0IPW3	Os12g0163700 protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00053	T cell activation	P01332	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00391	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00907	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	7925653	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CAEBR|Gene=CBG00120|UniProtKB=A8WMB7	Protein CBR-MYO-2	ISS			PTHR13140:SF473	MYOSIN-2
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00048	PI3 kinase pathway	P01187	IR	DROME|FlyBase=FBgn0283499|UniProtKB=P09208	Insulin-like receptor	TAS	11943559	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CHICK|Ensembl=ENSGALG00000008898|UniProtKB=F1P2J9	Uncharacterized protein	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=3020|UniProtKB=P21728	D(1A) dopamine receptor	IDA			PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00020	FAS signaling pathway	P00594	Caspase8	MACMU|Ensembl=ENSMMUG00000012310|UniProtKB=F7DL95	CASP8 and FADD-like apoptosis regulator isoform 1	ISS	9211860	PubMed	PTHR10454:SF8	CASP8 AND FADD-LIKE APOPTOSIS REGULATOR
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00052	TGF-beta signaling pathway	P01284	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MOUSE|MGI=MGI=1336171|UniProtKB=Q9DAS9	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IDA	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P02749	Leucine biosynthesis	P02999	2-Isopropylmalate synthase	BACSU|EnsemblGenome=BSU28280|UniProtKB=P94565	2-isopropylmalate synthase	ISS			PTHR10277:SF9	2-ISOPROPYLMALATE SYNTHASE 1, CHLOROPLASTIC-RELATED
P00036	Interleukin signaling pathway	P00965	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IC	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	RCA	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	ARATH|TAIR=AT5G61210|UniProtKB=Q9S7P9	SNAP25 homologous protein SNAP33	IC			PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05918	p38 MAPK pathway	P06031	p38alpha	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00036	Interleukin signaling pathway	P00977	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95818|UniProtKB=Q61626	Glutamate receptor ionotropic, kainate 5	ISS	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MOUSE|MGI=MGI=106203|UniProtKB=Q60665	Ski-like protein	IGI	10485843	PubMed	PTHR10005:SF3	SKI-LIKE PROTEIN
P00021	FGF signaling pathway	P00633	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000006594|UniProtKB=F7AKA6	Uncharacterized protein	ISS			PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	IC	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000000931|UniProtKB=H2PZC4	Protein kinase N2	ISS	11554554	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00036	Interleukin signaling pathway	P00973	PKB	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02728	Arginine biosynthesis	P02841	argininosuccinate lyase	METAC|EnsemblGenome=MA_1318|UniProtKB=Q8TR65	Argininosuccinate lyase	ISS			PTHR43814:SF1	ARGININOSUCCINATE LYASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DANRE|ZFIN=ZDB-GENE-040718-93|UniProtKB=Q6DGZ5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00019	Endothelin signaling pathway	P00591	PLCbeta	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00034	Integrin signalling pathway	P00926	GRAF	RAT|RGD=1588859|UniProtKB=D4AB50	Protein Arhgap10	ISS	8649427	PubMed	PTHR12552:SF5	RHO GTPASE-ACTIVATING PROTEIN 10
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00050	Plasminogen activating cascade	P01250	MMP-13	CANLF|Ensembl=ENSCAFG00000015043|UniProtKB=F1PVS9	Uncharacterized protein	TAS	12834808	PubMed	PTHR10201:SF165	COLLAGENASE 3
P00029	Huntington disease	P00807	Actin	CANAL|CGD=CAL0064759|UniProtKB=Q5AKX0	Uncharacterized protein	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CHICK|Ensembl=ENSGALG00000003014|UniProtKB=P09481	Neuronal acetylcholine receptor subunit alpha-3	IC	85270494	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P00018	EGF receptor signaling pathway	P00545	JNK1-3	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IGI	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00562	p38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IGI	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IDA	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P02728	Arginine biosynthesis	P02841	argininosuccinate lyase	PANTR|Ensembl=ENSPTRG00000019245|UniProtKB=H2RBX6	Argininosuccinate lyase	ISS			PTHR43814:SF1	ARGININOSUCCINATE LYASE
P02736	Coenzyme A biosynthesis	P02884	Dephospho-CoA kinase	STRCO|EnsemblGenome=CAB52052|UniProtKB=Q9S2K7	Dephospho-CoA kinase	ISS			PTHR10695:SF26	BIFUNCTIONAL COENZYME A SYNTHASE
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=4594|UniProtKB=Q14416	Metabotropic glutamate receptor 2	IDA	12351712	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00005	Angiogenesis	P00203	Erk	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	P01486	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00256	PLC-gamma	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	DICDI|dictyBase=DDB_G0293434|UniProtKB=P15064	Ras-like protein rasG	ISS	89128893	PubMed	PTHR24070:SF282	RAS GTPASE-RELATED
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P06664	Gonadotropin-releasing hormone receptor pathway	P06768	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	RCA	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00168	E-cadherin intracellular fragment	MOUSE|MGI=MGI=88354|UniProtKB=P09803	Cadherin-1	IDA	11953314	PubMed	PTHR24027:SF319	CADHERIN-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00047	PDGF signaling pathway	P01168	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=98953|UniProtKB=P04426	Proto-oncogene Wnt-1	TAS	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IC	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00633	Ras	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	PANTR|Ensembl=ENSPTRG00000008090|UniProtKB=H2QB20	Uncharacterized protein	ISS	10487978	PubMed	PTHR10749:SF8	PHOSPHORYLASE B KINASE REGULATORY SUBUNIT BETA
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000008783|UniProtKB=E1BD86	Uncharacterized protein	ISS			PTHR24247:SF116	5-HYDROXYTRYPTAMINE RECEPTOR 7
P00004	Alzheimer disease-presenilin pathway	P00145	CD44	MOUSE|MGI=MGI=88338|UniProtKB=P15379	CD44 antigen	IDA	14871815	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	STRPU|EnsemblGenome=SPU_005033|UniProtKB=W4XNQ0	Uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF263	SUBFAMILY NOT NAMED
P06214	GBB signaling pathway	P06305	MAD	DROME|FlyBase=FBgn0011648|UniProtKB=P42003	Protein mothers against dpp	IGI	7768443	PubMed	PTHR13703:SF40	PROTEIN MOTHERS AGAINST DPP
P05916	Opioid prodynorphin pathway	P06002	G-protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	ISS	12488551	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00046	Oxidative stress response	P01131	MKP5	DROME|FlyBase=FBgn0036844|UniProtKB=Q9VVW5	Dual specificity protein phosphatase Mpk3	TAS			PTHR10159:SF489	DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3
P00036	Interleukin signaling pathway	P00973	PKB	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00639	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	10982827	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00049	Parkinson disease	P01230	Src kinase	CANLF|Gene=YES1|UniProtKB=Q28923	Tyrosine-protein kinase Yes	IDA	11078745	PubMed	PTHR24418:SF90	TYROSINE-PROTEIN KINASE YES
P00017	DNA replication	P00533	Pol delta	DROME|FlyBase=FBgn0263600|UniProtKB=P54358	DNA polymerase delta catalytic subunit	ISS	96125196	PubMed	PTHR10322:SF23	DNA POLYMERASE DELTA CATALYTIC SUBUNIT
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	PSEAE|EnsemblGenome=PA1984|UniProtKB=Q9I2C4	NAD+ dependent aldehyde dehydrogenase ExaC	IC			PTHR43111:SF1	ALDEHYDE DEHYDROGENASE B
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MOUSE|MGI=MGI=87904|UniProtKB=P60710	Actin, cytoplasmic 1	IC	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	RAT|RGD=621408|UniProtKB=Q62763	Casein kinase I isoform gamma-3	IDA	11437445	PubMed	PTHR11909:SF151	CASEIN KINASE I ISOFORM GAMMA-3
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	PANTR|Ensembl=ENSPTRG00000002149|UniProtKB=H2R0U9	Uncharacterized protein	ISS	8930069	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	ARATH|TAIR=AT1G53570|UniProtKB=F4HRJ4	Mitogen-activated protein kinase kinase kinase 3	ISS			PTHR24361:SF337	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=19218|UniProtKB=Q86YW0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1	ISS	10934033	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P04393	Ras Pathway	P04579	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00010	B cell activation	P00384	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00046	Oxidative stress response	P01129	JNK1/2	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00925	MEK	CHICK|Ensembl=ENSGALG00000001001|UniProtKB=F1P3T1	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00059	p53 pathway	P04630	PP2A	RAT|RGD=3381|UniProtKB=P62716	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04392	P53 pathway feedback loops 1	P04539	p53	BOVIN|Ensembl=ENSBTAG00000001069|UniProtKB=P67939	Cellular tumor antigen p53	TAS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00048	PI3 kinase pathway	P01177	P110ACT	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	HUMAN|HGNC=9508|UniProtKB=P49768	Presenilin-1	TAS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	DANRE|ZFIN=ZDB-GENE-000330-9|UniProtKB=Q90ZE4	Presenilin-2	TAS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00054	Toll receptor signaling pathway	P01375	JNK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	ISS	11007936	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	CHICK|Ensembl=ENSGALG00000001476|UniProtKB=F1NSA8	Uncharacterized protein	ISS	10476970	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05913	Enkephalin release	P05974	G-Protein (i)	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00054	Toll receptor signaling pathway	P01355	AP1	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00036	Interleukin signaling pathway	P00968	Ikk	CANLF|Ensembl=ENSCAFG00000009588|UniProtKB=E2RNA9	Uncharacterized protein	ISS	12235208	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00029	Huntington disease	P00774	Dynein complex	HUMAN|HGNC=2955|UniProtKB=O96015	Dynein light chain 4, axonemal	IPI	9454836	PubMed	PTHR11886:SF2	DYNEIN LIGHT CHAIN 4, AXONEMAL
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CANLF|Ensembl=ENSCAFG00000005662|UniProtKB=E2R907	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	IDA	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	XENTR|Xenbase=XB-GENE-478483|UniProtKB=F6W2E6	Glycoprotein hormones alpha chain	ISS	15927770	PubMed	PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02769	Purine metabolism	P03117	5'-AMP Deaminase	MACMU|Ensembl=ENSMMUG00000015785|UniProtKB=F7AVX9	Uncharacterized protein	ISS	1420359	PubMed	PTHR11359:SF2	AMP DEAMINASE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	TAKRU|Ensembl=ENSTRUG00000007253|UniProtKB=H2SZQ1	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00021	FGF signaling pathway	P00642	MEK1-2	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00034	Integrin signalling pathway	P00948	Rho	RAT|RGD=621309|UniProtKB=P62747	Rho-related GTP-binding protein RhoB	ISS	13679859	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00038	JAK/STAT signaling pathway	P01034	Jak	HUMAN|HGNC=6190|UniProtKB=P23458	Tyrosine-protein kinase JAK1	ISS	9637709	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P04375	5HT3 type receptor mediated signaling pathway	P04425	K+ channel	CHICK|Ensembl=ENSGALG00000016193|UniProtKB=E1BYI0	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DICDI|dictyBase=DDB_G0283903|UniProtKB=Q54QB1	Extracellular signal-regulated kinase 2	IDA	10851062	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00021	FGF signaling pathway	P00643	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05972	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00053	T cell activation	P01330	IKK	CANLF|Ensembl=ENSCAFG00000009588|UniProtKB=E2RNA9	Uncharacterized protein	ISS	9346484	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04567	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01319	PAK	CHICK|Ensembl=ENSGALG00000006426|UniProtKB=E1BS97	Uncharacterized protein	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00034	Integrin signalling pathway	P00949	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	8264585	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00059	p53 pathway	P04618	PML	MACMU|Ensembl=ENSMMUG00000002569|UniProtKB=F7HSN6	Uncharacterized protein	ISS	14992722	PubMed	PTHR45211:SF1	PROTEIN PML
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	SCHPO|PomBase=SPAC10F6.13c|UniProtKB=O42652	Aspartate aminotransferase, cytoplasmic	ISS			PTHR11879:SF22	ASPARTATE AMINOTRANSFERASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	BOVIN|Ensembl=ENSBTAG00000017639|UniProtKB=F1MZW8	Ribosomal protein S6 kinase	ISS	2779569	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	SYNY3|EnsemblGenome=BAA18334|UniProtKB=P74240	Ribonucleoside-diphosphate reductase subunit alpha	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00053	T cell activation	P01306	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04393	Ras Pathway	P04543	MEKK1/4	HUMAN|HGNC=6856|UniProtKB=Q9Y6R4	Mitogen-activated protein kinase kinase kinase 4	IDA	11730323	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	CAEEL|WormBase=WBGene00009119|UniProtKB=Q93576	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IDA	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00018	EGF receptor signaling pathway	P00560	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00047	PDGF signaling pathway	P01173	STAT	CANLF|Ensembl=ENSCAFG00000015509|UniProtKB=F1PNW8	Signal transducer and activator of transcription	ISS	96102059	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	PANTR|Gene=CHRM3|UniProtKB=Q9N2A4	Muscarinic acetylcholine receptor M3	TAS	8100450	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	MOUSE|MGI=MGI=1351345|UniProtKB=P47743	Metabotropic glutamate receptor 8	IC	12488551	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00029	Huntington disease	P00775	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00049	Parkinson disease	P01211	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00025	Hedgehog signaling pathway	P00682	PKA	NEUCR|EnsemblGenome=EFNCRG00000004240|UniProtKB=Q01386	cAMP-dependent protein kinase regulatory subunit	ISS	97076137	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P04393	Ras Pathway	P04567	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00046	Oxidative stress response	P01135	p38	CAEBR|Gene=CBG01555|UniProtKB=A8WRD7	Mitogen-activated protein kinase	ISS	11703092	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	RCA	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00022	General transcription by RNA polymerase I	P00652	RNA Polymerase I  Complex	ARATH|TAIR=AT1G29940|UniProtKB=F4I366	DNA-directed RNA polymerase I subunit 2	ISS	15691654	PubMed	PTHR20856:SF5	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA2
P05917	Opioid proopiomelanocortin pathway	P06009	K+ channel	BOVIN|Ensembl=ENSBTAG00000047488|UniProtKB=G3N1D1	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00036	Interleukin signaling pathway	P00968	Ikk	CANLF|Ensembl=ENSCAFG00000005526|UniProtKB=E2RKR0	Uncharacterized protein	ISS	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00025	Hedgehog signaling pathway	P00682	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	DANRE|ZFIN=ZDB-GENE-000330-9|UniProtKB=Q90ZE4	Presenilin-2	IDA	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00057	Wnt signaling pathway	P01457	GBeta	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	8262392	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00021	FGF signaling pathway	P00646	RasGAP	CANLF|Ensembl=ENSCAFG00000007674|UniProtKB=E2QUM7	Uncharacterized protein	ISS	20475167	gi	PTHR10194:SF21	RAS GTPASE-ACTIVATING PROTEIN 2
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00025	Hedgehog signaling pathway	P00689	Patched	XENTR|Xenbase=XB-GENE-488222|UniProtKB=F7DZP4	Uncharacterized protein	ISS	21095181	PubMed	PTHR10796:SF61	PROTEIN PATCHED HOMOLOG 1
P00057	Wnt signaling pathway	P01438	PP2A	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P05916	Opioid prodynorphin pathway	P06002	G-protein	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00025	Hedgehog signaling pathway	P00692	GSK3	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MACMU|Ensembl=ENSMMUG00000016549|UniProtKB=F6W5A7	Matrix metalloproteinase-9	ISS	12834808	PubMed	PTHR10201:SF30	MATRIX METALLOPROTEINASE-9
P00057	Wnt signaling pathway	P01435	SWI/SNF	HUMAN|HGNC=11097|UniProtKB=P28370	Probable global transcription activator SNF2L1	IDA	11532957	PubMed	PTHR10799:SF819	GLOBAL TRANSCRIPTION ACTIVATOR SNF2L1-RELATED
P00034	Integrin signalling pathway	P00919	Arf6	TAKRU|Ensembl=ENSTRUG00000011714|UniProtKB=H2TY29	Uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Ensembl=ENSPTRG00000022245|UniProtKB=H2QZ29	Uncharacterized protein	ISS	20112749	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	IDA	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02785	Valine biosynthesis	P03216	Acetolactate synthase	CANLF|Ensembl=ENSCAFG00000016130|UniProtKB=F1Q255	Uncharacterized protein	ISS			PTHR18968:SF155	ACETOLACTATE SYNTHASE-LIKE PROTEIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01063	CAT	BOVIN|Ensembl=ENSBTAG00000016814|UniProtKB=F1MLQ5	Uncharacterized protein	ISS	97225904	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	XENTR|Xenbase=XB-GENE-6469705|UniProtKB=Q6P8G3	Actin, alpha sarcomeric/skeletal	ISS	14684598	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P06959	CCKR signaling map	P07079	p38MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	RCA	11343700	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	HUMAN|HGNC=239|UniProtKB=P40145	Adenylate cyclase type 8	IGI	12890691	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05915	Opioid proenkephalin pathway	P05992	met-Enkephalin	DANRE|ZFIN=ZDB-GENE-030729-31|UniProtKB=A8E7S2	Uncharacterized protein	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	MACMU|Ensembl=ENSMMUG00000010542|UniProtKB=F7D0L2	Segment polarity protein dishevelled homolog DVL-2	ISS	10409711	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00790	beta-Tubulin	PANTR|Gene=TUBB8|UniProtKB=Q8WP14	Tubulin beta-8 chain	TAS	12932731	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00005	Angiogenesis	P00256	PLC-gamma	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	IC	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00053	T cell activation	P01300	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	MACMU|Ensembl=ENSMMUG00000007605|UniProtKB=F6SJQ8	Uncharacterized protein	ISS	96032356	PubMed	PTHR11958:SF22	EXCITATORY AMINO ACID TRANSPORTER 5
P00059	p53 pathway	P01486	Akt	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	TAS	12089061	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	8787761	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	PYRAE|EnsemblGenome=PAE1996|UniProtKB=Q8ZW33	Glutamate dehydrogenase	ISS			PTHR11606:SF13	GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00053	T cell activation	P01311	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_206575|UniProtKB=E9FUX0	Guanine nucleotide binding protein, beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	MACMU|Ensembl=ENSMMUG00000006285|UniProtKB=F7H0Y1	Uncharacterized protein	ISS			PTHR11482:SF4	ANTIZYME INHIBITOR 2
P00030	Hypoxia response via HIF activation	P00824	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	TAS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	IDA	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IDA	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05913	Enkephalin release	P05972	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	CHICK|Ensembl=ENSGALG00000007509|UniProtKB=F1NM72	Uncharacterized protein	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00057	Wnt signaling pathway	P01433	SIAH-1	MOUSE|MGI=MGI=108064|UniProtKB=P61092	E3 ubiquitin-protein ligase SIAH1A	IDA	14985507	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00029	Huntington disease	P00807	Actin	ORYSJ|EnsemblGenome=OS05G0106600|UniProtKB=Q65XH8	Os05g0106600 protein	IDA	10974003	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	ARATH|TAIR=AT2G43790|UniProtKB=Q39026	Mitogen-activated protein kinase 6	TAS			PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00057	Wnt signaling pathway	P01431	LRP5/6	PANTR|Ensembl=ENSPTRG00000003983|UniProtKB=H2Q4A0	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00018	EGF receptor signaling pathway	P00561	STAT	HUMAN|HGNC=11366|UniProtKB=P42229	Signal transducer and activator of transcription 5A	IGI	96210005	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00018	EGF receptor signaling pathway	P00558	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05913	Enkephalin release	P05974	G-Protein (i)	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00019	Endothelin signaling pathway	P00572	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00047	PDGF signaling pathway	P01171	PLCgamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00013	Cell cycle	P00480	Proteasome	BOVIN|Ensembl=ENSBTAG00000021461|UniProtKB=Q2KJ46	26S proteasome non-ATPase regulatory subunit 3	ISS	2568889	PubMed	PTHR10758:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3
P00029	Huntington disease	P00786	ARF	MONDO|Ensembl=ENSMODG00000023112|UniProtKB=F7ABF7	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF119	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 4C
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	MOUSE|MGI=MGI=1321161|UniProtKB=P62715	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00211	GSK3beta	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04393	Ras Pathway	P04570	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00633	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DICPU|Gene=DICPUDRAFT_90232|UniProtKB=F1A175	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00048	PI3 kinase pathway	G01544	GADD45	BOVIN|Ensembl=ENSBTAG00000013860|UniProtKB=Q3ZBN6	Growth arrest and DNA damage-inducible protein GADD45 alpha	ISS	9827804	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P00019	Endothelin signaling pathway	P00582	COX-2	RAT|RGD=620349|UniProtKB=P35355	Prostaglandin G/H synthase 2	IGI	14684611	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P00019	Endothelin signaling pathway	P00566	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IGI	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00049	Parkinson disease	P01238	14-3-3	ORYSJ|EnsemblGenome=OS11G0546900|UniProtKB=Q2R2W2	14-3-3-like protein GF14-D	ISS	10407019	PubMed	PTHR18860:SF34	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05913	Enkephalin release	P05974	G-Protein (i)	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	IC	12488551	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00205	GAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	DANRE|ZFIN=ZDB-GENE-050417-59|UniProtKB=Q15KE4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P06587	Nicotine pharmacodynamics pathway	P06593	CHRNA5	BOVIN|Ensembl=ENSBTAG00000013657|UniProtKB=Q8SPU7	Neuronal acetylcholine receptor subunit alpha-5	ISS	12388584	PubMed	PTHR18945:SF76	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00859	NFkappaB	RAT|RGD=735070|UniProtKB=Q6P780	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	ISS			PTHR24118:SF37	NF-KAPPA-B INHIBITOR EPSILON
P00057	Wnt signaling pathway	P01443	Phospholipase C	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00029	Huntington disease	P00774	Dynein complex	YEAST|SGD=S000002832|UniProtKB=Q02647	Dynein light chain 1, cytoplasmic	IPI	9454836	PubMed	PTHR11886:SF35	DYNEIN LIGHT CHAIN 2, CYTOPLASMIC
P00053	T cell activation	P01331	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00206	Wnt	CANLF|Ensembl=ENSCAFG00000008760|UniProtKB=E2RTG8	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01438	PP2A	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	88107662	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00215	Nck	PANTR|Ensembl=ENSPTRG00000015434|UniProtKB=G2HHN0	Cytoplasmic protein NCK1	ISS	11689432	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	PANTR|Ensembl=ENSPTRG00000011333|UniProtKB=H2R5W8	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF462	MYOSIN-14
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	HUMAN|HGNC=6695|UniProtKB=O75074	Low-density lipoprotein receptor-related protein 3	IDA	11907044	PubMed	PTHR44062:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 3
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=109503|UniProtKB=Q5RJH3	Cadherin-12	IDA	8120095	PubMed	PTHR24027:SF96	CADHERIN-12
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8690|UniProtKB=Q9Y5E4	Protocadherin beta-5	IDA	8120095	PubMed	PTHR24028:SF90	PROTOCADHERIN BETA-5
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	XENTR|Xenbase=XB-GENE-992519|UniProtKB=F6VS22	Uncharacterized protein	ISS	11248120	PubMed	PTHR43893:SF8	D 1B  DOPAMINE RECEPTOR
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	LEIMA|EnsemblGenome=LmjF.35.3960|UniProtKB=E9AFM1	Protein kinase A catalytic subunit isoform 2	IC	10553940	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	CANLF|Ensembl=ENSCAFG00000013324|UniProtKB=F1PCS0	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT1G59580|UniProtKB=Q39022	Mitogen-activated protein kinase 2	ISS	176948	OMIM	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P06959	CCKR signaling map	P07129	FAK1	HUMAN|HGNC=9611|UniProtKB=Q05397	Focal adhesion kinase 1	RCA	15688067	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00056	VEGF signaling pathway	P01411	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00113	Erb-B4 transmembrane fragment	MOUSE|MGI=MGI=104771|UniProtKB=Q61527	Receptor tyrosine-protein kinase erbB-4	ISS	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00005	Angiogenesis	P00208	MEKK1	RAT|RGD=620966|UniProtKB=Q62925	Mitogen-activated protein kinase kinase kinase 1	ISS	8940199	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	RCA	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04658	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	CRYNJ|EnsemblGenome=CND03830|UniProtKB=Q5KI86	Uncharacterized protein	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06831	p38	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	RCA	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	BOVIN|Gene=CHRNA3|UniProtKB=Q07263	Neuronal acetylcholine receptor subunit alpha-3	ISS	85270494	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P00036	Interleukin signaling pathway	P00976	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IPI	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00036	Interleukin signaling pathway	P00972	MNK1/2	HUMAN|HGNC=7110|UniProtKB=Q9BUB5	MAP kinase-interacting serine/threonine-protein kinase 1	TAS	11575158	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00005	Angiogenesis	P00182	p38MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	22040490	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PHYPA|Gene=PHYPADRAFT_198730|UniProtKB=Q6TYS2	Actin 1	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IC	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DROME|FlyBase=FBgn0010333|UniProtKB=P40792	Ras-related protein Rac1	ISS	95047333	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00866	Cytokine receptor	MOUSE|MGI=MGI=107654|UniProtKB=Q63953	Ifngr2 protein	IDA	14525967	PubMed	PTHR20859:SF46	INTERFERON GAMMA RECEPTOR 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	PANTR|Ensembl=ENSPTRG00000015853|UniProtKB=H2QP48	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF14	G PROTEIN-COUPLED RECEPTOR KINASE 4
P00005	Angiogenesis	P00255	Notch	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00018	EGF receptor signaling pathway	P00552	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	DANRE|ZFIN=ZDB-GENE-011010-3|UniProtKB=Q90Y03	Aldehyde dehydrogenase 1A2	IC			PTHR11699:SF102	RETINAL DEHYDROGENASE 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00059	p53 pathway	G04694	p110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IGI	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2522|UniProtKB=P30729	D(4) dopamine receptor	IDA	11248120	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00029	Huntington disease	P00761	Truncated Htt	CANLF|Ensembl=ENSCAFG00000014682|UniProtKB=F1P7Y7	Uncharacterized protein	ISS	8268927	PubMed	PTHR10170:SF10	HUNTINGTIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00060	Ubiquitin proteasome pathway	P01490	E3	BOVIN|Ensembl=ENSBTAG00000015720|UniProtKB=Q32PG0	E3 ubiquitin-protein ligase	ISS			PTHR11254:SF299	NEDD4-LIKE E3 UBIQUITIN-PROTEIN LIGASE WWP1
P00011	Blood coagulation	P00453	FXIII	CHICK|Ensembl=ENSGALG00000012802|UniProtKB=E1BWG1	Uncharacterized protein	ISS	10636369	gi	PTHR11590:SF42	COAGULATION FACTOR XIII A CHAIN
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00053	T cell activation	P01336	Jnk	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	BOVIN|Gene=PLCD4|UniProtKB=P21671	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	TAS			PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00060	Ubiquitin proteasome pathway	P01491	E2	PANTR|Ensembl=ENSPTRG00000040524|UniProtKB=H2RIJ3	Uncharacterized protein	ISS			PTHR24067:SF3	UBIQUITIN-CONJUGATING ENZYME E2 G1
P00021	FGF signaling pathway	P00646	RasGAP	HUMAN|HGNC=9871|UniProtKB=P20936	Ras GTPase-activating protein 1	IGI	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00010	B cell activation	P00384	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00006	Apoptosis signaling pathway	P00317	Fos	PANTR|Ensembl=ENSPTRG00000006553|UniProtKB=A5A6H0	C-fos	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00029	Huntington disease	P00801	Fos protein	RAT|RGD=2626|UniProtKB=P12841	Proto-oncogene c-Fos	TAS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00057	Wnt signaling pathway	P01446	Calcineurin	RAT|RGD=69230|UniProtKB=P63100	Calcineurin subunit B type 1	ISS	12015605	PubMed	PTHR23056:SF43	CALCINEURIN SUBUNIT B TYPE 1
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CHICK|Ensembl=ENSGALG00000009844|UniProtKB=P68034	Actin, alpha cardiac muscle 1	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04393	Ras Pathway	P04542	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	RAT|RGD=2350|UniProtKB=P12390	Neuronal acetylcholine receptor subunit beta-2	IC	15155845	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00053	T cell activation	P01307	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05915	Opioid proenkephalin pathway	P05994	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008026|UniProtKB=H2QAZ2	Syntaxin 1B	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06774	AR	MOUSE|MGI=MGI=88064|UniProtKB=P19091	Androgen receptor	RCA			PTHR24084:SF6	ANDROGEN RECEPTOR
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	ISS	1333286	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00019	Endothelin signaling pathway	P00572	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00629	PP2A	ARATH|TAIR=AT1G17720|UniProtKB=Q39247	Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform	ISS			PTHR11871:SF0	PROTEIN PHOSPHATASE PP2A 55 KDA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00562	p38	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	IGI	10995439	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00047	PDGF signaling pathway	P01163	c-Jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00057	Wnt signaling pathway	P01451	Galpha	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00628	JNK1-3	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00174	CD44 N-terminal fragment	MOUSE|MGI=MGI=88338|UniProtKB=P15379	CD44 antigen	IDA	14871815	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P00029	Huntington disease	P00771	Sin3A	ORNAN|Ensembl=ENSOANG00000010605|UniProtKB=F7B0D4	Uncharacterized protein	ISS	10441327	PubMed	PTHR12346:SF2	PAIRED AMPHIPATHIC HELIX PROTEIN SIN3A
P00006	Apoptosis signaling pathway	P00268	GCK	CAEEL|WormBase=WBGene00022603|UniProtKB=Q23290	Mitogen-activated protein kinase kinase kinase kinase	ISS			PTHR24361:SF413	HAPPYHOUR, ISOFORM A
P00005	Angiogenesis	P00211	GSK3beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346347|UniProtKB=Q9WVS8	Mitogen-activated protein kinase 7	ISS	15085193	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	RCA	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	BOVIN|Ensembl=ENSBTAG00000013843|UniProtKB=F1MIW7	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF66	SERINE/THREONINE-PROTEIN KINASE RECEPTOR R3
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	RCA	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	PANTR|Ensembl=ENSPTRG00000020105|UniProtKB=Q5IS52	Neuronal acetylcholine receptor subunit alpha-2	ISS	85270494	PubMed	PTHR18945:SF757	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	BOVIN|Ensembl=ENSBTAG00000010740|UniProtKB=P04975	Clathrin light chain B	ISS	11889126	PubMed	PTHR10639:SF2	CLATHRIN LIGHT CHAIN B
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	EMENI|EnsemblGenome=CADANIAG00007315|UniProtKB=P20359	Actin, gamma	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	BOVIN|Ensembl=ENSBTAG00000003043|UniProtKB=P63212	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00056	VEGF signaling pathway	P01425	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00023	General transcription regulation	P00668	TFIIB	HUMAN|HGNC=4648|UniProtKB=Q00403	Transcription initiation factor IIB	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00050	Plasminogen activating cascade	P01244	PAI-2	HUMAN|HGNC=8584|UniProtKB=P05120	Plasminogen activator inhibitor 2	IDA	4505595	gi	PTHR11461:SF61	PLASMINOGEN ACTIVATOR INHIBITOR 2
P00056	VEGF signaling pathway	P01417	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	12068308	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P04395	Vasopressin synthesis	P04589	Signal Peptidase	DROME|FlyBase=FBgn0030306|UniProtKB=Q9VYY2	Signal peptidase complex subunit 2	IC	2092035	PubMed	PTHR13085:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 2
P00021	FGF signaling pathway	P00632	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00165	E-cadherin N-terminal fragment	PANTR|Ensembl=ENSPTRG00000008270|UniProtKB=H2QBE5	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF319	CADHERIN-1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	ORNAN|Ensembl=ENSOANG00000004058|UniProtKB=F6TYP9	Uncharacterized protein	ISS	20112749	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MONDO|Ensembl=ENSMODG00000018065|UniProtKB=F7G485	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	7925653	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00053	T cell activation	P01318	PKC-theta	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IGI	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02756	N-acetylglucosamine metabolism	P03041	Glucosamine-6-phosphate deaminase	CHICK|Ensembl=ENSGALG00000007312|UniProtKB=F1N906	Glucosamine-6-phosphate isomerase	ISS			PTHR11280:SF8	GLUCOSAMINE-6-PHOSPHATE ISOMERASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00899	IRS 1-4	RAT|RGD=2922|UniProtKB=P35570	Insulin receptor substrate 1	ISS	12701063	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00005	Angiogenesis	P00243	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00029	Huntington disease	P00807	Actin	PLAF7|EnsemblGenome=PFL2215w|UniProtKB=Q8I4X0	Actin-1	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04393	Ras Pathway	P04569	Cdc42	BRAFL|Gene=BRAFLDRAFT_122664|UniProtKB=C3ZIB9	Putative uncharacterized protein	ISS	4757952	gi	PTHR24072:SF192	CDC42 HOMOLOG
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	CANLF|Ensembl=ENSCAFG00000028654|UniProtKB=J9P702	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MACMU|Ensembl=ENSMMUG00000017431|UniProtKB=F7HPP3	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01395	TFIIE	CANLF|Ensembl=ENSCAFG00000011306|UniProtKB=E2R3P2	Uncharacterized protein	ISS	189962	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	MONDO|Ensembl=ENSMODG00000020352|UniProtKB=F7FKB2	Uncharacterized protein	ISS	96032356	PubMed	PTHR11958:SF24	EXCITATORY AMINO ACID TRANSPORTER 1
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	PANTR|Ensembl=ENSPTRG00000003795|UniProtKB=H2Q3X5	Muscarinic acetylcholine receptor	ISS	10069496	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00025	Hedgehog signaling pathway	P00682	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00024	Glycolysis	P00671	Phosphoglycerate kinase	ANOGA|EnsemblGenome=AGAP008802|UniProtKB=Q7Q850	Phosphoglycerate kinase	ISS	22875075	PubMed	PTHR11406:SF0	PHOSPHOGLYCERATE KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00749	RGS9	HUMAN|HGNC=10004|UniProtKB=O75916	Regulator of G-protein signaling 9	IDA	9459445	PubMed	PTHR10845:SF170	REGULATOR OF G-PROTEIN SIGNALING 9
P00018	EGF receptor signaling pathway	P00560	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	MACMU|Ensembl=ENSMMUG00000011773|UniProtKB=F7HQF4	Uncharacterized protein	ISS	12181435	PubMed	PTHR24247:SF31	5-HYDROXYTRYPTAMINE RECEPTOR 2B
P00054	Toll receptor signaling pathway	P01375	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00053	T cell activation	P01305	Calmodulin	CANLF|Ensembl=ENSCAFG00000016335|UniProtKB=J9NXY2	Uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF322	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MACMU|Ensembl=ENSMMUG00000023587|UniProtKB=Q9XT45	C-X-C chemokine receptor type 6	ISS	2209288	gi	PTHR10489:SF705	C-X-C CHEMOKINE RECEPTOR TYPE 6
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	RAT|RGD=62045|UniProtKB=Q99PS2	Casein kinase1 epsilon-2	IDA	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IDA	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00048	PI3 kinase pathway	P01185	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00005	Angiogenesis	P00223	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00052	TGF-beta signaling pathway	P01275	P38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00056	VEGF signaling pathway	P01411	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00057	Wnt signaling pathway	P01428	Frizzled	XENTR|Xenbase=XB-GENE-479707|UniProtKB=F6QAW3	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF126	FRIZZLED-5
P00006	Apoptosis signaling pathway	P00313	IKK	HUMAN|HGNC=1974|UniProtKB=O15111	Inhibitor of nuclear factor kappa-B kinase subunit alpha	IDA	12235208	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MYCTU|EnsemblGenome=Rv0357c|UniProtKB=P9WHN3	Adenylosuccinate synthetase	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00059	p53 pathway	P01480	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IDA	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00009	Axon guidance mediated by netrin	P00363	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	ISS	8700226	PubMed	PTHR10048:SF14	PI-3 KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=1855699|UniProtKB=O89116	Vesicle transport through interaction with t-SNAREs homolog 1A	ISS	10908612	PubMed	PTHR21230:SF39	VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A
P02738	De novo purine biosynthesis	P02901	Adenosuccinate lyase	SCHPO|PomBase=SPBC14F5.09c|UniProtKB=O60105	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00053	T cell activation	P01336	Jnk	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00054	Toll receptor signaling pathway	G01550	Gene trancription	BOVIN|Ensembl=ENSBTAG00000033695|UniProtKB=P01576	Interferon beta-2	ISS			PTHR11691:SF43	INTERFERON BETA
P00018	EGF receptor signaling pathway	P00539	14-3-3	CHICK|Gene_ORFName=RCJMB04_5e12|UniProtKB=Q5F3W6	14-3-3 protein gamma	ISS	10407019	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	MOUSE|MGI=MGI=102891|UniProtKB=P51829	Adenylate cyclase type 7	IC	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00049	Parkinson disease	P01227	20S proteasome	SCHPO|PomBase=SPCC1795.04c|UniProtKB=O59770	Probable proteasome subunit alpha type-7	TAS	12859888	PubMed	PTHR11599:SF10	PROTEASOME SUBUNIT ALPHA TYPE-3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00048	PI3 kinase pathway	G01545	scl-1	CAEEL|WormBase=WBGene00004742|UniProtKB=Q20608	SCP-Like extracellular protein	ISS			PTHR10334:SF185	SCP-LIKE EXTRACELLULAR PROTEIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00718	Phosphorylase a	MOUSE|MGI=MGI=97830|UniProtKB=Q9WUB3	Glycogen phosphorylase, muscle form	IDA	4318782	PubMed	PTHR11468:SF13	GLYCOGEN PHOSPHORYLASE, MUSCLE FORM
P00021	FGF signaling pathway	P00629	PP2A	TAKRU|Ensembl=ENSTRUG00000003840|UniProtKB=H2S9H8	Uncharacterized protein	ISS	8703017	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00005	Angiogenesis	P00200	Dsh	PANTR|Ensembl=ENSPTRG00000008665|UniProtKB=H2QC24	Dishevelled, dsh homolog 2	ISS	11212302	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P00053	T cell activation	P01336	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00546	GAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00034	Integrin signalling pathway	P00912	Arp2/3	DANRE|ZFIN=ZDB-GENE-040120-7|UniProtKB=Q7ZWH4	Actin-related protein 2/3 complex subunit 5	IPI	12473693	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00057	Wnt signaling pathway	P01443	Phospholipase C	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00021	FGF signaling pathway	P00629	PP2A	ORYSJ|EnsemblGenome=OS03G0167700|UniProtKB=Q10R90	Serine/threonine-protein phosphatase	ISS	93341450	PubMed	PTHR11668:SF265	SUBFAMILY NOT NAMED
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	BOVIN|Ensembl=ENSBTAG00000047648|UniProtKB=G5E6N8	Uncharacterized protein	ISS	600104	OMIM	PTHR10024:SF223	SYNAPTOTAGMIN-2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	IDA	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00789	PSD-95	BOVIN|Ensembl=ENSBTAG00000002564|UniProtKB=F1MM66	Uncharacterized protein	ISS	12932731	PubMed	PTHR23119:SF33	DISKS LARGE HOMOLOG 4
P05730	Endogenous cannabinoid signaling	P05751	Galpha	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05913	Enkephalin release	P05977	G-Protein (s)	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00056	VEGF signaling pathway	P01407	Erk	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01428	Frizzled	CHICK|Gene=FZD1|UniProtKB=O57328	Frizzled-1	IDA	11212302	PubMed	PTHR11309:SF81	FRIZZLED-1
P04398	p53 pathway feedback loops 2	P04668	p53	DANRE|ZFIN=ZDB-GENE-990415-270|UniProtKB=P79734	Cellular tumor antigen p53	TAS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00044	Nicotinic acetylcholine receptor signaling pathway	P01094	gamma	RAT|RGD=2354|UniProtKB=P18916	Acetylcholine receptor subunit gamma	ISS	95224005	PubMed	PTHR18945:SF60	ACETYLCHOLINE RECEPTOR SUBUNIT GAMMA
P06664	Gonadotropin-releasing hormone receptor pathway	P06795	STAT3	MOUSE|MGI=MGI=103038|UniProtKB=P42227	Signal transducer and activator of transcription 3	RCA	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P06587	Nicotine pharmacodynamics pathway	P06602	PPP1CA	HUMAN|HGNC=9281|UniProtKB=P62136	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit	TAS	8392016	PubMed	PTHR11668:SF377	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-ALPHA CATALYTIC SUBUNIT
P00057	Wnt signaling pathway	P01465	Ggamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00029	Huntington disease	P00780	Microtubule	RAT|RGD=735101|UniProtKB=Q6P9T8	Tubulin beta-4B chain	ISS	12932731	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	SCLS1|EnsemblGenome=SS1G_03482|UniProtKB=A7EDU2	Guanine nucleotide-binding protein beta subunit	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00053	T cell activation	P01307	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	DANRE|ZFIN=ZDB-GENE-030131-8783|UniProtKB=Q52WY2	Ras-like protein Cdc42a	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04392	P53 pathway feedback loops 1	P04537	p73DeltaN	RAT|RGD=620863|UniProtKB=Q9JJP6	Tumor protein 63	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00830	Lipoxygenase	RAT|RGD=70493|UniProtKB=Q02759	Arachidonate 15-lipoxygenase	TAS	12432925	PubMed	PTHR11771:SF33	ARACHIDONATE 15-LIPOXYGENASE
P00049	Parkinson disease	P01211	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00021	FGF signaling pathway	P00640	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00047	PDGF signaling pathway	P01174	Rho	PANTR|Ensembl=ENSPTRG00000004204|UniProtKB=H2Q4L7	Rho GTPase activating protein 42	ISS			PTHR12552:SF3	RHO GTPASE-ACTIVATING PROTEIN 42
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00046	Oxidative stress response	P01134	cPLA2	BOVIN|Ensembl=ENSBTAG00000013298|UniProtKB=A4IFJ5	Cytosolic phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IDA	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01446	Calcineurin	ANOGA|EnsemblGenome=AGAP004298|UniProtKB=F5HLK4	AGAP004298-PA	ISS	12015605	PubMed	PTHR23056:SF4	PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	NEUCR|EnsemblGenome=EFNCRG00000003893|UniProtKB=P78711	Actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00021	FGF signaling pathway	P00634	MEKK1-5	MACMU|Ensembl=ENSMMUG00000016751|UniProtKB=F7AIB6	Mitogen-activated protein kinase kinase kinase 3 isoform 1	ISS	8649450	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00018	EGF receptor signaling pathway	P00552	Ras	HUMAN|HGNC=10447|UniProtKB=P10301	Ras-related protein R-Ras	ISS	7997267	PubMed	PTHR24070:SF245	RAS-RELATED PROTEIN R-RAS
P00056	VEGF signaling pathway	P01407	Erk	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00050	Plasminogen activating cascade	P01243	uPA	CHICK|Gene=PLAU|UniProtKB=P15120	Urokinase-type plasminogen activator	ISS	137111	gi	PTHR44246:SF2	UROKINASE-TYPE PLASMINOGEN ACTIVATOR
P00005	Angiogenesis	P00249	PAK	ORNAN|Ensembl=ENSOANG00000002406|UniProtKB=F7BAS2	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00019	Endothelin signaling pathway	P00566	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00012	Cadherin signaling pathway	P00464	Fyn	MOUSE|MGI=MGI=95602|UniProtKB=P39688	Tyrosine-protein kinase Fyn	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	MOUSE|MGI=MGI=1916969|UniProtKB=B2RQC6	CAD protein	ISS			PTHR11405:SF5	CAD PROTEIN
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	TRIAD|EnsemblGenome=TriadG63380|UniProtKB=B3S653	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	ORNAN|Ensembl=ENSOANG00000002226|UniProtKB=F6TPX7	Ribosomal protein S6 kinase	ISS	11861821	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00019	Endothelin signaling pathway	P00570	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00035	Interferon-gamma signaling pathway	P00953	Jak1	CANLF|Ensembl=ENSCAFG00000018615|UniProtKB=F1PIY7	Tyrosine-protein kinase	ISS	9637709	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00053	T cell activation	P01311	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00012	Cadherin signaling pathway	P00474	Wnt	CANLF|Ensembl=ENSCAFG00000005291|UniProtKB=E2QXQ3	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	HUMAN|HGNC=4574|UniProtKB=P48058	Glutamate receptor 4	ISS	12941441	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00048	PI3 kinase pathway	P01206	14-3-3	MACMU|Ensembl=ENSMMUG00000006489|UniProtKB=F7EFF6	14-3-3 protein zeta/delta	ISS	12615066	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P04393	Ras Pathway	P04578	Rho	DANRE|ZFIN=ZDB-GENE-040426-2150|UniProtKB=Q6NUX8	Rho-related GTP-binding protein RhoA-A	ISS	14871999	PubMed	PTHR24072:SF260	RHO-RELATED GTP-BINDING PROTEIN RHOA-A-RELATED
P00052	TGF-beta signaling pathway	P01292	RSmads	CANLF|Ensembl=ENSCAFG00000006162|UniProtKB=E2R326	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF41	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 9
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04668	p53	PANTR|Ensembl=ENSPTRG00000008703|UniProtKB=H2QC53	Cellular tumor antigen p53	ISS	11313951	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TAKRU|Ensembl=ENSTRUG00000005447|UniProtKB=P68142	Actin, cytoplasmic 1	IC	14684598	PubMed	PTHR11937:SF354	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	IDA	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04392	P53 pathway feedback loops 1	P04539	p53	ORNAN|Ensembl=ENSOANG00000013795|UniProtKB=F7DUR2	Uncharacterized protein (Fragment)	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	HUMAN|HGNC=7161|UniProtKB=P51511	Matrix metalloproteinase-15	TAS	12834808	PubMed	PTHR10201:SF25	MATRIX METALLOPROTEINASE-15
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	PANTR|Ensembl=ENSPTRG00000014847|UniProtKB=H2QMG5	Uncharacterized protein	ISS			PTHR10489:SF913	C-C CHEMOKINE RECEPTOR TYPE 2
P00034	Integrin signalling pathway	P00927	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00005	Angiogenesis	P00203	Erk	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	IC	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	TAS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	IC	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00317	Fos	PANTR|Ensembl=ENSPTRG00000006553|UniProtKB=A5A6H0	C-fos	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00029	Huntington disease	P00807	Actin	DICDI|dictyBase=DDB_G0268744|UniProtKB=Q55EU6	Putative actin-23	IDA	14684598	PubMed	PTHR11937:SF154	ACTIN-17-RELATED
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00059	p53 pathway	G04700	PAI	RAT|RGD=3249|UniProtKB=P20961	Plasminogen activator inhibitor 1	ISS	10692390	PubMed	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	DROME|FlyBase=FBgn0000150|UniProtKB=P08879	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05912	Dopamine receptor mediated signaling pathway	P05950	DARPP-32	RAT|RGD=621859|UniProtKB=Q6J4I0	Protein phosphatase 1 regulatory subunit 1B	ISS	3339428	PubMed	PTHR15417:SF2	PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 1B
P00021	FGF signaling pathway	P00624	14-3-3	MOUSE|MGI=MGI=109484|UniProtKB=P63101	14-3-3 protein zeta/delta	ISS	1499718	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04393	Ras Pathway	P04559	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12912997	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000002349|UniProtKB=P61267	Syntaxin-1B	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	MOUSE|MGI=MGI=96433|UniProtKB=Q60751	Insulin-like growth factor 1 receptor	ISS	6754360	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MOUSE|MGI=MGI=88396|UniProtKB=P12657	Muscarinic acetylcholine receptor M1	IDA	8100450	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	LEIMA|EnsemblGenome=LmjF.35.4010|UniProtKB=Q9GNR4	Protein kinase A catalytic subunit isoform 1	IC	10553940	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00011	Blood coagulation	P00409	PAI-2	RAT|RGD=621823|UniProtKB=P29524	Plasminogen activator inhibitor 2 type A	ISS	11067431	gi	PTHR11461:SF61	PLASMINOGEN ACTIVATOR INHIBITOR 2
P04393	Ras Pathway	P04542	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00005	Angiogenesis	P00221	JNK1	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	ISS	12040174	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00057	Wnt signaling pathway	P01430	p53	CANLF|Gene=TP53|UniProtKB=Q29537	Cellular tumor antigen p53	IDA	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P05913	Enkephalin release	P05977	G-Protein (s)	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CAEEL|WormBase=WBGene00000065|UniProtKB=P0DM42	Actin-3	ISS	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00045	Notch signaling pathway	P01103	Next	MOUSE|MGI=MGI=1098270|UniProtKB=Q9QYE5	Protein jagged-2	ISS	12826675	PubMed	PTHR44097:SF1	PROTEIN JAGGED-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00203	Erk	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	XENTR|Xenbase=XB-GENE-484012|UniProtKB=F6R871	Serine/threonine-protein kinase receptor	ISS	11252892	PubMed	PTHR23255:SF64	ACTIVIN RECEPTOR TYPE-2A
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IDA	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P06587	Nicotine pharmacodynamics pathway	P06602	PPP1CA	BOVIN|Gene=PPP1CA|UniProtKB=Q3T0E7	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit	ISS	10433257	PubMed	PTHR11668:SF377	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-ALPHA CATALYTIC SUBUNIT
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000001867|UniProtKB=H2Q0X8	Adenosine receptor A1	ISS	12106606	PubMed	PTHR24246:SF1	ADENOSINE RECEPTOR A1
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00006	Apoptosis signaling pathway	P00318	PKCs	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05913	Enkephalin release	P05972	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05913	Enkephalin release	P05974	G-Protein (i)	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	IC	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00030	Hypoxia response via HIF activation	P00823	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	129387	gi	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	PANTR|Gene=HTR2C|UniProtKB=Q5IS66	5-hydroxytryptamine receptor 2C	ISS	12441358	PubMed	PTHR24247:SF32	5-HYDROXYTRYPTAMINE RECEPTOR 2C
P00019	Endothelin signaling pathway	P00590	IP3 R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	21244534	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P02744	Fructose galactose metabolism	P02965	UDP Glucose 4 epimerase	YEAST|SGD=S000000223|UniProtKB=P04397	Bifunctional protein GAL10	RCA			PTHR43725:SF8	UDP-GLUCOSE 4-EPIMERASE
P00034	Integrin signalling pathway	P00948	Rho	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	IGI	12169092	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00034	Integrin signalling pathway	P00938	Cdc42	DAPPU|EnsemblGenome=DAPPUDRAFT_306746|UniProtKB=E9GYE9	Putative uncharacterized protein	ISS	4757952	gi	PTHR24072:SF192	CDC42 HOMOLOG
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	ENTHI|EnsemblGenome=EHI_181250|UniProtKB=C4M5Z7	Rho family GTPase	ISS	4757952	gi	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00059	p53 pathway	P01480	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00047	PDGF signaling pathway	P01153	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	MOUSE|MGI=MGI=1933367|UniProtKB=Q99N48	Synaptotagmin-like protein 3	RCA			PTHR10024:SF222	SYNAPTOTAGMIN-LIKE PROTEIN 3
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	TAKRU|Ensembl=ENSTRUG00000003520|UniProtKB=H2S791	Uncharacterized protein	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DICPU|Gene=DICPUDRAFT_48914|UniProtKB=F0ZK40	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF154	ACTIN-17-RELATED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IDA	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00056	VEGF signaling pathway	P01407	Erk	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	PANTR|Ensembl=ENSPTRG00000003946|UniProtKB=H2Q482	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	BOVIN|Ensembl=ENSBTAG00000021887|UniProtKB=E1BFN6	Uncharacterized protein	ISS	9718352	PubMed	PTHR11647:SF50	DIHYDROPYRIMIDINASE
P05731	GABA-B receptor II signaling	P05755	Gbeta	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00057	Wnt signaling pathway	P01461	FrzB	MACMU|Gene=SFRP4|UniProtKB=Q7YRN1	Secreted frizzled-related protein 4	ISS	9118218	PubMed	PTHR11309:SF7	SECRETED FRIZZLED-RELATED PROTEIN 4
P00048	PI3 kinase pathway	P01188	Gbetagamma	RAT|RGD=1595475|UniProtKB=D4AAI1	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF26	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT GAMMA-T1
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	12846562	PubMed	PTHR10202:SF13	PRESENILIN-2
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	TAS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04398	p53 pathway feedback loops 2	P04661	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	ISS	96320556	PubMed	PTHR10048:SF14	PI-3 KINASE
P00049	Parkinson disease	P01235	Fyn kinase	MACMU|Ensembl=ENSMMUG00000017017|UniProtKB=F7FVL2	Tyrosine-protein kinase	ISS	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00009	Axon guidance mediated by netrin	P00364	cdc42	BRAFL|Gene=BRAFLDRAFT_122664|UniProtKB=C3ZIB9	Putative uncharacterized protein	ISS	4757952	gi	PTHR24072:SF192	CDC42 HOMOLOG
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_126324|UniProtKB=C3XYC2	Putative uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00021	FGF signaling pathway	P00648	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	RAT|RGD=2323682|UniProtKB=P58200	Vesicle transport through interaction with t-SNAREs homolog 1B	ISS	14570579	PubMed	PTHR21230:SF26	VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1B
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CHICK|Ensembl=ENSGALG00000006638|UniProtKB=R4GGL9	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P02743	Formyltetrahydroformate biosynthesis	P02958	Dihydrofolate synthase	BACSU|EnsemblGenome=BSU28080|UniProtKB=Q05865	Folylpolyglutamate synthase	ISS			PTHR11136:SF0	DIHYDROFOLATE SYNTHETASE-RELATED
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	CHICK|Ensembl=ENSGALG00000000681|UniProtKB=E1C3P6	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000003399|UniProtKB=H2Q383	Phosphoinositide-3-kinase, class 2, alpha polypeptide	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00115	Nicastrin	HUMAN|HGNC=17091|UniProtKB=Q92542	Nicastrin	IDA	10993067	PubMed	PTHR21092:SF0	NICASTRIN
P00057	Wnt signaling pathway	P01465	Ggamma	ORNAN|Ensembl=ENSOANG00000013961|UniProtKB=F6VPY1	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	CANLF|Ensembl=ENSCAFG00000005526|UniProtKB=E2RKR0	Uncharacterized protein	ISS	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Gene=DRD2|UniProtKB=P60026	D(2) dopamine receptor	ISS	1319557	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	LEIMA|EnsemblGenome=LmjF.08.1230|UniProtKB=Q4QI42	Beta tubulin	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	XENTR|Xenbase=XB-GENE-977853|UniProtKB=F7EBE7	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00018	EGF receptor signaling pathway	P00551	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IGI	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	MOUSE|MGI=MGI=1351342|UniProtKB=Q3UVX5	Metabotropic glutamate receptor 5	ISS	14614461	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	MONDO|Ensembl=ENSMODG00000018204|UniProtKB=F6PGX6	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00005	Angiogenesis	P00235	c-Fos	PANTR|Ensembl=ENSPTRG00000006553|UniProtKB=A5A6H0	C-fos	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=99402|UniProtKB=Q60613	Adenosine receptor A2a	IDA			PTHR24246:SF27	ADENOSINE RECEPTOR A2A
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	HUMAN|HGNC=4586|UniProtKB=Q13224	Glutamate receptor ionotropic, NMDA 2B	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00023	General transcription regulation	P00658	TBP-associated factors	DROME|FlyBase=FBgn0011291|UniProtKB=P49906	Transcription initiation factor TFIID subunit 11	ISS			PTHR13218:SF8	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	IC			PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DICDI|dictyBase=DDB_G0280061|UniProtKB=Q6TMJ9	Synaptobrevin-A	ISS	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	XENTR|Xenbase=XB-GENE-956713|UniProtKB=Q5XGD8	Guanine nucleotide binding protein, beta 3	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00047	PDGF signaling pathway	P01151	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00233	CSL	XENTR|Xenbase=XB-GENE-490756|UniProtKB=F7BXC9	Uncharacterized protein (Fragment)	ISS	12145413	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00057	Wnt signaling pathway	P01465	Ggamma	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00010	B cell activation	P00391	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00780	Microtubule	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g229095|UniProtKB=A7S027	Predicted protein	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00807	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g242065|UniProtKB=A7S0V7	Predicted protein	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00010	B cell activation	P00381	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00951	Jnk	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00052	TGF-beta signaling pathway	P01286	TGFbeta	PANTR|Ensembl=ENSPTRG00000005130|UniProtKB=H2Q6B1	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF130	INHIBIN BETA C CHAIN
P00057	Wnt signaling pathway	P01452	NFAT	MOUSE|MGI=MGI=1920431|UniProtKB=Q8K120	Nuclear factor of activated T-cells, cytoplasmic 4	IDA	9462517	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P02733	Carnitine metabolism	P02866	Carnitine dehydratase	DROME|FlyBase=FBgn0038804|UniProtKB=Q9VDL4	LP04613p	ISS			PTHR43949:SF6	SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE
P00029	Huntington disease	G01535	PIG3	BOVIN|Ensembl=ENSBTAG00000018146|UniProtKB=Q29RL6	Uncharacterized protein	ISS	12932731	PubMed	PTHR44054:SF2	SYNAPTIC VESICLE MEMBRANE PROTEIN VAT-1 HOMOLOG-LIKE
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MACMU|Ensembl=ENSMMUG00000010266|UniProtKB=F6PV18	Uncharacterized protein	ISS	14500986	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	BOVIN|Ensembl=ENSBTAG00000014674|UniProtKB=P41985	Muscarinic acetylcholine receptor M2	ISS	91373358	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00034	Integrin signalling pathway	P00941	Integrin alpha	BOVIN|Ensembl=ENSBTAG00000008380|UniProtKB=F1N157	Uncharacterized protein	ISS	3487386	PubMed	PTHR23220:SF21	INTEGRIN ALPHA-11
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	PANTR|Ensembl=ENSPTRG00000009321|UniProtKB=H2QD96	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	BOVIN|Ensembl=ENSBTAG00000004322|UniProtKB=O77628	Proto-oncogene c-Fos	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05918	p38 MAPK pathway	P06040	MSK1	CHICK|Gene_ORFName=RCJMB04_14g1|UniProtKB=Q5F3L1	Ribosomal protein S6 kinase alpha-5	ISS	6755374	gi	PTHR24351:SF115	RIBOSOMAL PROTEIN S6 KINASE ALPHA-5
P00016	Cytoskeletal regulation by Rho GTPase	P00514	MLCK	CHICK|Ensembl=ENSGALG00000006273|UniProtKB=E1BX17	Uncharacterized protein	TAS	600922	OMIM	PTHR45210:SF1	MYOSIN LIGHT CHAIN KINASE 2, SKELETAL/CARDIAC MUSCLE
P00011	Blood coagulation	P00429	PN2	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00010	B cell activation	P00371	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Gene=PKN1|UniProtKB=A1A4I4	Serine/threonine-protein kinase N1	ISS	10644715	PubMed	PTHR24356:SF246	SERINE/THREONINE-PROTEIN KINASE N1
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	BOVIN|Ensembl=ENSBTAG00000005903|UniProtKB=F1N1K8	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P04393	Ras Pathway	P04570	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	TAKRU|Ensembl=ENSTRUG00000015959|UniProtKB=H2UV27	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	BOVIN|Ensembl=ENSBTAG00000003454|UniProtKB=P79348	Regulator of G-protein signaling 20	IDA	8756726	PubMed	PTHR10845:SF175	REGULATOR OF G-PROTEIN SIGNALING 20
P04393	Ras Pathway	P04541	p90RSK	BOVIN|Ensembl=ENSBTAG00000014447|UniProtKB=A4IFF4	Ribosomal protein S6 kinase	ISS	12769834	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00012	Cadherin signaling pathway	P00474	Wnt	XENTR|Xenbase=XB-GENE-480396|UniProtKB=F7DI28	Protein Wnt (Fragment)	ISS	8717036	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00269	MAPK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00010	B cell activation	P00379	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00644	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	MOUSE|MGI=MGI=1339946|UniProtKB=P62340	TATA box-binding protein-like protein 1	ISS	600075	OMIM	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	CHICK|Ensembl=ENSGALG00000011809|UniProtKB=F1NMB0	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MACMU|Ensembl=ENSMMUG00000007445|UniProtKB=F6SWI4	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00019	Endothelin signaling pathway	P00568	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IGI	10644715	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00005	Angiogenesis	P00238	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00052	TGF-beta signaling pathway	P01285	TAK	MONDO|Ensembl=ENSMODG00000018170|UniProtKB=F7CCD5	Uncharacterized protein	RCA			PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P00012	Cadherin signaling pathway	P00470	F-actin	XENTR|GeneID=394982|UniProtKB=P20399	Actin, alpha cardiac muscle 2	ISS	10974003	PubMed	PTHR11937:SF263	ACTIN
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=1921305|UniProtKB=Q8K4S1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	7822322	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	RAT|RGD=2521|UniProtKB=P19020	D(3) dopamine receptor	ISS	2039532	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00029	Huntington disease	P00807	Actin	PRIPA|Gene=PPA23459|UniProtKB=H3FMF2	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DICDI|dictyBase=DDB_G0268622|UniProtKB=P34145	Rho-related protein rac1B	ISS	8649368	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04547	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00007	Axon guidance mediated by semaphorins	P00340	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00045	Notch signaling pathway	P01103	Next	PANTR|Ensembl=ENSPTRG00000010617|UniProtKB=H2QFL8	Notch 3	ISS	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00012	Cadherin signaling pathway	P00462	Casein kinase II	MONDO|Ensembl=ENSMODG00000015287|UniProtKB=F6T6M8	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P05915	Opioid proenkephalin pathway	P05994	G-protein	ORNAN|Ensembl=ENSOANG00000003489|UniProtKB=F7FSE3	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IDA	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00021	FGF signaling pathway	P00641	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00021	FGF signaling pathway	P00632	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00631	Grb2	CAEBR|Gene=CBG16856|UniProtKB=A8XPY6	Protein CBR-SEM-5	ISS	17569445	gi	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MACMU|Ensembl=ENSMMUG00000017683|UniProtKB=F6UA63	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00025	Hedgehog signaling pathway	P00688	Hedgehog	BRAFL|Gene=BRAFLDRAFT_84974|UniProtKB=C3ZGW9	Hedgehog protein	ISS			PTHR11889:SF31	PROTEIN HEDGEHOG
P00045	Notch signaling pathway	P01108	Nicastrin	DROME|FlyBase=FBgn0039234|UniProtKB=Q9VC27	Nicastrin	TAS	16096062	PubMed	PTHR21092:SF0	NICASTRIN
P00021	FGF signaling pathway	P00629	PP2A	DANRE|ZFIN=ZDB-GENE-030904-7|UniProtKB=Q8AXX6	Ppp2r5e2 protein	ISS	11007767	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00029	Huntington disease	P00787	MAPKK4	HUMAN|HGNC=6844|UniProtKB=P45985	Dual specificity mitogen-activated protein kinase kinase 4	NAS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02732	Coenzyme A linked carnitine metabolism	P02864	L-carnitine dehydratase	MOUSE|MGI=MGI=1923221|UniProtKB=Q7TNE1	Succinate--hydroxymethylglutarate CoA-transferase	ISS			PTHR43949:SF6	SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8972|UniProtKB=O00750	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00010	B cell activation	P00379	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CHICK|Ensembl=ENSGALG00000008898|UniProtKB=F1P2J9	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00059	p53 pathway	P04616	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	9094314	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	DANRE|ZFIN=ZDB-GENE-010125-1|UniProtKB=B8JHS2	Uncharacterized protein	IDA	11259487	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	MOUSE|MGI=MGI=104742|UniProtKB=P63250	G protein-activated inward rectifier potassium channel 1	ISS	12374786	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00047	PDGF signaling pathway	P01150	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IDA	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	RAT|RGD=1306620|UniProtKB=B1H230	Map2k3 protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	DEIRA|EnsemblGenome=DR_0451|UniProtKB=Q9RX64	Glutamine synthase	ISS			PTHR43785:SF1	TYPE-1 GLUTAMINE SYNTHETASE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=88399|UniProtKB=P32211	Muscarinic acetylcholine receptor M4	IDA	8100450	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	IDA	8838325	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00012	Cadherin signaling pathway	P00471	Cadherin	CANLF|Ensembl=ENSCAFG00000019841|UniProtKB=E2R4F0	Uncharacterized protein	ISS	8120095	PubMed	PTHR24026:SF32	CADHERIN EGF LAG SEVEN-PASS G-TYPE RECEPTOR 2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CANLF|Ensembl=ENSCAFG00000008756|UniProtKB=F2Z4N8	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=620308|UniProtKB=P30936	Somatostatin receptor type 3	IDA	12441358	PubMed	PTHR24229:SF42	SOMATOSTATIN RECEPTOR TYPE 3
P02746	Heme biosynthesis	P02983	Hydroxymethylbilane synthase	MOUSE|MGI=MGI=96112|UniProtKB=P22907	Porphobilinogen deaminase	ISS			PTHR11557:SF0	PORPHOBILINOGEN DEAMINASE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00020	FAS signaling pathway	P00615	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00023	General transcription regulation	P00668	TFIIB	DROME|FlyBase=FBgn0038499|UniProtKB=Q9VEL2	Brf, isoform A	ISS	180660	OMIM	PTHR11618:SF4	TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT
P00005	Angiogenesis	P00190	RasGAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	2842690	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ANOGA|EnsemblGenome=AGAP005911|UniProtKB=Q7Q6D4	AGAP005911-PA	IC	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	RCA	2372396	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P05734	Synaptic vesicle trafficking	P05774	NSF	RAT|RGD=621594|UniProtKB=Q9QUL6	Vesicle-fusing ATPase	ISS	7969419	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00049	Parkinson disease	P01211	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00327	FADD	HUMAN|HGNC=3573|UniProtKB=Q13158	FAS-associated death domain protein	IDA	7536190	PubMed	PTHR15077:SF8	FAS-ASSOCIATED DEATH DOMAIN PROTEIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000005238|UniProtKB=F7BWT2	Uncharacterized protein	ISS	11701344	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IGI	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00057	Wnt signaling pathway	P01448	CBP	ARATH|TAIR=AT3G12980|UniProtKB=Q9LE42	Histone acetyltransferase HAC5	IDA	10769018	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	DANRE|ZFIN=ZDB-GENE-020125-4|UniProtKB=F1QKT1	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	BOVIN|Ensembl=ENSBTAG00000037794|UniProtKB=E1BP87	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF681	MYOSIN-4
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00589	Akt	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	IGI	12655147	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01192	p110	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	HUMAN|HGNC=711|UniProtKB=P49407	Beta-arrestin-1	ISS	4757780	gi	PTHR11792:SF22	BETA-ARRESTIN-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00005	Angiogenesis	P00254	GTPase	XENTR|Xenbase=XB-GENE-489222|UniProtKB=Q28GJ8	Ras homolog gene family, member A	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P04393	Ras Pathway	P04569	Cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00021	FGF signaling pathway	P00640	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	ISS	188830	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00049	Parkinson disease	P01211	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00020	FAS signaling pathway	P00600	PARP	HUMAN|HGNC=272|UniProtKB=Q9UGN5	Poly [ADP-ribose] polymerase 2	TAS	12101391	PubMed	PTHR10459:SF60	POLY  ADP-RIBOSE  POLYMERASE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P02778	Sulfate assimilation	P03167	Sulfate adenylyltransferase	CHICK|Ensembl=ENSGALG00000010542|UniProtKB=E1C8P2	Uncharacterized protein	ISS			PTHR11055:SF17	BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE 1
P00006	Apoptosis signaling pathway	P00274	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05934	ELK1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	RCA	3183861	gi	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00048	PI3 kinase pathway	P01188	Gbetagamma	DAPPU|EnsemblGenome=DAPPUDRAFT_206575|UniProtKB=E9FUX0	Guanine nucleotide binding protein, beta subunit	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00029	Huntington disease	P00790	beta-Tubulin	MONDO|Ensembl=ENSMODG00000016603|UniProtKB=F6ZCX3	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF112	TUBULIN BETA-1 CHAIN
P00004	Alzheimer disease-presenilin pathway	P00114	actin	HUMAN|HGNC=143|UniProtKB=P68032	Actin, alpha cardiac muscle 1	IDA	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00006	Apoptosis signaling pathway	P00305	Caspase 3	TAKRU|Ensembl=ENSTRUG00000015915|UniProtKB=H2UUR6	Uncharacterized protein (Fragment)	ISS	9323209	PubMed	PTHR10454:SF198	CASPASE-3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MACMU|Ensembl=ENSMMUG00000012229|UniProtKB=F6VF32	Uncharacterized protein	ISS	22028976	PubMed	PTHR13140:SF387	MYOSIN-IIIA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04393	Ras Pathway	P04553	PAK	MOUSE|MGI=MGI=1339984|UniProtKB=Q8CIN4	Serine/threonine-protein kinase PAK 2	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00048	PI3 kinase pathway	P01177	P110ACT	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P06214	GBB signaling pathway	P06296	PPM1A	DROME|FlyBase=FBgn0086361|UniProtKB=Q961C5	Alphabet, isoform E	IEA	http://flybase.org/reports/FBgn0086361.html	Website	PTHR13832:SF524	PROTEIN PHOSPHATASE 1A, MAGNESIUM DEPENDENT, ALPHA ISOFORM-RELATED
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	MACMU|Ensembl=ENSMMUG00000014555|UniProtKB=F7GT55	Syntaxin-1A isoform 1	ISS	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00034	Integrin signalling pathway	P00912	Arp2/3	PANTR|Ensembl=ENSPTRG00000019449|UniProtKB=H2QV01	Actin related protein 2/3 complex, subunit 1B, 41kDa	ISS	9618202	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	IDA	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	ARATH|TAIR=AT1G62800|UniProtKB=P46646	Aspartate aminotransferase, cytoplasmic isozyme 2	ISS			PTHR11879:SF22	ASPARTATE AMINOTRANSFERASE
P00007	Axon guidance mediated by semaphorins	P00340	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	RCA	10693759	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00038	JAK/STAT signaling pathway	P01027	STAT	HUMAN|HGNC=11364|UniProtKB=P40763	Signal transducer and activator of transcription 3	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00057	Wnt signaling pathway	P01438	PP2A	HUMAN|HGNC=9300|UniProtKB=P62714	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	IDA	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	TAKRU|Ensembl=ENSTRUG00000006307|UniProtKB=H2SSM1	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00038	JAK/STAT signaling pathway	P01027	STAT	HUMAN|HGNC=11364|UniProtKB=P40763	Signal transducer and activator of transcription 3	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00034	Integrin signalling pathway	P00951	Jnk	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g234494|UniProtKB=A7RU31	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	RAT|RGD=1304988|UniProtKB=A0A0G2K6Q8	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	DROME|FlyBase=FBgn0001991|UniProtKB=Q24270	Voltage-dependent calcium channel type D subunit alpha-1	IC	9199552	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00001	Adrenaline and noradrenaline biosynthesis	P00063	DBH	DROME|FlyBase=FBgn0010329|UniProtKB=Q86B61	Tyramine beta-hydroxylase	ISS	90219125	PubMed	PTHR10157:SF29	DOPAMINE BETA-HYDROXYLASE
P00048	PI3 kinase pathway	P01188	Gbetagamma	CAEEL|WormBase=WBGene00001679|UniProtKB=P17343	Guanine nucleotide-binding protein subunit beta-1	IC	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P05917	Opioid proopiomelanocortin pathway	P06006	beta-Endorphin	MOUSE|MGI=MGI=97742|UniProtKB=P01193	Pro-opiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P04393	Ras Pathway	P04559	Rac	ANOGA|EnsemblGenome=AGAP005445|UniProtKB=Q7PNL6	AGAP005445-PA	ISS	12588856	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00010	B cell activation	P00391	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00054	Toll receptor signaling pathway	P01344	TRIF	MOUSE|MGI=MGI=3040056|UniProtKB=Q8BJQ4	TIR domain-containing adapter molecule 2	ISS			PTHR22811:SF75	TIR DOMAIN-CONTAINING ADAPTER MOLECULE 2
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	ANOGA|EnsemblGenome=AGAP010321|UniProtKB=Q7Q2H6	AGAP010321-PA	ISS	2187864	PubMed	PTHR11800:SF2	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04397	p53 pathway by glucose deprivation	P04644	TSC2	HUMAN|HGNC=12363|UniProtKB=P49815	Tuberin	ISS	12150915	PubMed	PTHR10063:SF0	TUBERIN
P00047	PDGF signaling pathway	P01162	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00036	Interleukin signaling pathway	P00996	STAT	CANLF|Ensembl=ENSCAFG00000015509|UniProtKB=F1PNW8	Signal transducer and activator of transcription	ISS	96102059	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00019	Endothelin signaling pathway	P00577	PI3K	ARATH|TAIR=AT1G60490|UniProtKB=P42339	Phosphatidylinositol 3-kinase VPS34	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MOUSE|MGI=MGI=87892|UniProtKB=Q8R493	Neuronal acetylcholine receptor subunit beta-4	IC	22213672	PubMed	PTHR18945:SF385	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	IDA	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00021	FGF signaling pathway	P00629	PP2A	PANTR|Ensembl=ENSPTRG00000018180|UniProtKB=H2QT14	Protein phosphatase 2, regulatory subunit B', delta	ISS	10092233	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00049	Parkinson disease	P01226	CDCrel-1	DROME|FlyBase=FBgn0259923|UniProtKB=Q0KHR7	Septin 4, isoform A	IDA			PTHR18884:SF109	SEPTIN 4, ISOFORM A
P00010	B cell activation	P00385	Rac	MACMU|Ensembl=ENSMMUG00000021075|UniProtKB=F7GY91	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	14744428	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01320	PLC-gamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P02728	Arginine biosynthesis	P02846	Ornithine carbamoyl transferase	BACSU|EnsemblGenome=BSU11250|UniProtKB=P18186	Ornithine carbamoyltransferase	ISS			PTHR11405:SF1	ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00011	Blood coagulation	P00461	PAR-4	PANTR|Ensembl=ENSPTRG00000029092|UniProtKB=H2R6B3	Uncharacterized protein	ISS	4503639	gi	PTHR24232:SF22	PROTEINASE-ACTIVATED RECEPTOR 4
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00059	p53 pathway	P04633	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01163	c-Jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	8837781	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00037	Ionotropic glutamate receptor pathway	P01005	NR2D	MOUSE|MGI=MGI=95823|UniProtKB=Q03391	Glutamate receptor ionotropic, NMDA 2D	ISS	11319238	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00048	PI3 kinase pathway	P01192	p110	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P04609	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	ISS	10799299	PubMed	PTHR10048:SF14	PI-3 KINASE
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	DEIRA|EnsemblGenome=DR_2630|UniProtKB=Q9RR67	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00034	Integrin signalling pathway	P00924	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=1339713|UniProtKB=Q5SX39	Myosin-4	IC	89264452	PubMed	PTHR13140:SF657	MYOSIN-4
P04398	p53 pathway feedback loops 2	P04668	p53	RAT|RGD=3889|UniProtKB=P10361	Cellular tumor antigen p53	TAS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P06664	Gonadotropin-releasing hormone receptor pathway	P06817	BMP2/4/15	MOUSE|MGI=MGI=88177|UniProtKB=P21274	Bone morphogenetic protein 2	RCA	9759503	PubMed	PTHR11848:SF143	BONE MORPHOGENETIC PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	RAT|RGD=1593249|UniProtKB=D3ZMQ3	Protein Itga4	ISS	3487386	PubMed	PTHR23220:SF78	INTEGRIN ALPHA-4
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00547	PP2A	BOVIN|Ensembl=ENSBTAG00000009245|UniProtKB=Q0P594	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	DAPPU|EnsemblGenome=DAPPUDRAFT_301140|UniProtKB=E9HGM4	Putative uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00010	B cell activation	P00391	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MOUSE|MGI=MGI=87894|UniProtKB=P20782	Acetylcholine receptor subunit epsilon	IC			PTHR18945:SF59	ACETYLCHOLINE RECEPTOR SUBUNIT EPSILON
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=107924|UniProtKB=Q64527	Protein Wnt-8a	IDA	11266476	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MOUSE|MGI=MGI=1338938|UniProtKB=P36895	Bone morphogenetic protein receptor type-1A	TAS	9395284	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P00021	FGF signaling pathway	P00645	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CAEBR|Gene=CBG02401|UniProtKB=A8WUE7	Protein CBR-NMR-1	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04397	p53 pathway by glucose deprivation	P04642	Rheb	XENTR|Xenbase=XB-GENE-492096|UniProtKB=F6TB23	Uncharacterized protein (Fragment)	ISS	12869586	PubMed	PTHR24070:SF264	GTP-BINDING PROTEIN RHEB
P05731	GABA-B receptor II signaling	P05754	Ggamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P02784	Tyrosine biosynthesis	P03213	Aromatic amino acid aminotransferase	BOVIN|Gene=TAT|UniProtKB=Q58CZ9	Tyrosine aminotransferase	ISS			PTHR11751:SF368	TYROSINE AMINOTRANSFERASE
P02728	Arginine biosynthesis	P02847	N-actetylornithine deacetylase	BACTN|EnsemblGenome=BT_3549|UniProtKB=Q8A1V9	Acetylornithine deacetylase	ISS			PTHR43808:SF8	SUBFAMILY NOT NAMED
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	RCA	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00475	Frizzled	CANLF|Ensembl=ENSCAFG00000004399|UniProtKB=E2RIL8	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF23	FRIZZLED-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=11331|UniProtKB=P30874	Somatostatin receptor type 2	IDA	12562507	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00050	Plasminogen activating cascade	P01245	PAI-1	BOVIN|Ensembl=ENSBTAG00000014465|UniProtKB=P13909	Plasminogen activator inhibitor 1	IDA	88329072	PubMed	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	CAEBR|Gene=CBG_05938|UniProtKB=H8WGV2	Protein CBR-ITR-1, isoform a	ISS	4262086	gi	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	HUMAN|HGNC=7573|UniProtKB=P11055	Myosin-3	IEP	89264452	PubMed	PTHR13140:SF427	MYOSIN-3
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	CHICK|Ensembl=ENSGALG00000015835|UniProtKB=F1NZT2	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00036	Interleukin signaling pathway	P00976	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	BOVIN|Ensembl=ENSBTAG00000011757|UniProtKB=Q9XT97	Presenilin-1	TAS	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000017549|UniProtKB=H2QS18	Dopamine receptor D1	ISS			PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P02756	N-acetylglucosamine metabolism	P03039	Glucosamine-1-phosphate acetyltransferase	STRCO|EnsemblGenome=CAD55493|UniProtKB=Q8CJX6	Bifunctional protein GlmU	ISS			PTHR43584:SF3	BIFUNCTIONAL PROTEIN GLMU
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=1921305|UniProtKB=Q8K4S1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	15611108	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01369	MKK1	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	DANRE|ZFIN=ZDB-GENE-030616-53|UniProtKB=Q71E60	AMPA receptor subunit GluR3B	ISS	12871085	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	DROME|FlyBase=FBgn0263111|UniProtKB=P91645	Voltage-dependent calcium channel type A subunit alpha-1	ISS	14507926	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P00038	JAK/STAT signaling pathway	P01031	PIAS	MOUSE|MGI=MGI=2136940|UniProtKB=Q9JM05	E3 SUMO-protein ligase PIAS4	ISS	8682149	PubMed	PTHR10782:SF9	E3 SUMO-PROTEIN LIGASE PIAS4
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	G01546	Cyclin d	MOUSE|MGI=MGI=88313|UniProtKB=P25322	G1/S-specific cyclin-D1	ISS	93330551	PubMed	PTHR10177:SF67	G1/S-SPECIFIC CYCLIN-D1
P05730	Endogenous cannabinoid signaling	P05743	CB1	ORNAN|Ensembl=ENSOANG00000000534|UniProtKB=F7CUB0	Uncharacterized protein	ISS	9888857	PubMed	PTHR22750:SF47	CANNABINOID RECEPTOR 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	XENTR|Xenbase=XB-GENE-479036|UniProtKB=Q640R7	Ras-related protein Rap-1b	ISS	1904317	PubMed	PTHR24070:SF382	RAS-RELATED PROTEIN RAP-1B
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00019	Endothelin signaling pathway	P00574	Big ET1-4	MACMU|Ensembl=ENSMMUG00000016131|UniProtKB=F7FQK2	Uncharacterized protein	ISS	10884419	PubMed	PTHR13874:SF11	ENDOTHELIN-3
P04393	Ras Pathway	P04557	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	IDA	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00010	B cell activation	P00381	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	TAS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00007	Axon guidance mediated by semaphorins	P00339	CRMP	RAT|RGD=2517|UniProtKB=P47942	Dihydropyrimidinase-related protein 2	ISS	Q90635	SPACC	PTHR11647:SF56	DIHYDROPYRIMIDINASE-RELATED PROTEIN 2
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	LEIMA|EnsemblGenome=LmjF.35.4010|UniProtKB=Q9GNR4	Protein kinase A catalytic subunit isoform 1	ISS	10553940	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01171	PLCgamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00009	Axon guidance mediated by netrin	P00364	cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=18539|UniProtKB=P61266	Syntaxin-1B	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P02746	Heme biosynthesis	P02972	Ferrochelatase	AQUAE|EnsemblGenome=aq_948|UniProtKB=O67083	Ferrochelatase	ISS			PTHR11108:SF1	FERROCHELATASE, MITOCHONDRIAL
P00012	Cadherin signaling pathway	P00474	Wnt	XENTR|Xenbase=XB-GENE-485280|UniProtKB=F6X3B2	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DICDI|dictyBase=DDB_G0269234|UniProtKB=P07830	Major actin	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00870	IL2	MOUSE|MGI=MGI=96539|UniProtKB=P43431	Interleukin-12 subunit alpha	IDA			PTHR45311:SF1	INTERLEUKIN-12 SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01300	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01208	Hsp70	METAC|EnsemblGenome=MA_1478|UniProtKB=Q8TQR2	Chaperone protein DnaK	IDA	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P00036	Interleukin signaling pathway	P00977	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00012	Cadherin signaling pathway	P00470	F-actin	CHLRE|EnsemblGenome=CHLREDRAFT_24392|UniProtKB=A8JAV1	Actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CHICK|Gene=CHRNA7|UniProtKB=P22770	Neuronal acetylcholine receptor subunit alpha-7	IC			PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P00010	B cell activation	P00374	Lyn	CANLF|Ensembl=ENSCAFG00000007034|UniProtKB=E2RBB8	Tyrosine-protein kinase	ISS	1371009	PubMed	PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00005	Angiogenesis	P00227	PLA2	BOVIN|Ensembl=ENSBTAG00000013298|UniProtKB=A4IFJ5	Cytosolic phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	PANTR|Ensembl=ENSPTRG00000006342|UniProtKB=H2Q8A8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00030	Hypoxia response via HIF activation	P00819	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00235	c-Fos	PANTR|Ensembl=ENSPTRG00000006553|UniProtKB=A5A6H0	C-fos	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	RCA	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00049	Parkinson disease	P01211	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	12657601	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	HUMAN|HGNC=20289|UniProtKB=Q8N752	Casein kinase I isoform alpha-like	ISS	10617630	PubMed	PTHR11909:SF139	CASEIN KINASE I ISOFORM ALPHA-LIKE
P05913	Enkephalin release	P05974	G-Protein (i)	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04375	5HT3 type receptor mediated signaling pathway	P04421	5HT transporter	CANLF|Ensembl=ENSCAFG00000018990|UniProtKB=F1PXA1	Transporter	ISS	7681602	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00012	Cadherin signaling pathway	P00466	EGFR	PANTR|Ensembl=ENSPTRG00000019196|UniProtKB=H2QUL1	Receptor protein-tyrosine kinase	ISS	21100872	PubMed	PTHR24416:SF91	EPIDERMAL GROWTH FACTOR RECEPTOR
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MOUSE|MGI=MGI=95770|UniProtKB=P30678	Guanine nucleotide-binding protein subunit alpha-15	IC	11534853	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=1306253|UniProtKB=D4A8X5	G protein-coupled receptor 45 (Predicted)	ISS			PTHR24245:SF4	G-PROTEIN COUPLED RECEPTOR 45-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000020588|UniProtKB=F7C0E0	Uncharacterized protein	ISS	125549	gi	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	IC	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	CANLF|Ensembl=ENSCAFG00000009812|UniProtKB=E2RIA0	Uncharacterized protein	ISS	12374786	PubMed	PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P00059	p53 pathway	G04694	p110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00226	Delta/Serrate	MOUSE|MGI=MGI=94900|UniProtKB=Q09163	Protein delta homolog 1	ISS			PTHR24052:SF11	PROTEIN DELTA HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00023	General transcription regulation	P00666	TFIIE	RAT|RGD=1306851|UniProtKB=G3V992	General transcription factor II E, polypeptide 1 (Alpha subunit)	ISS	92065982	PubMed	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	RCA	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00629	PP2A	CHICK|Ensembl=ENSGALG00000011840|UniProtKB=F1NLM6	Uncharacterized protein	ISS	8703017	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	ORYSJ|Gene=Os01g0866100|UniProtKB=P0C540	Actin-7	IC	10974003	PubMed	PTHR11937:SF205	SUBFAMILY NOT NAMED
P05913	Enkephalin release	P05972	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00006	Apoptosis signaling pathway	P00269	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IGI	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	HUMAN|HGNC=1076|UniProtKB=P36894	Bone morphogenetic protein receptor type-1A	TAS	9395284	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	DANRE|ZFIN=ZDB-GENE-030616-53|UniProtKB=Q71E60	AMPA receptor subunit GluR3B	ISS	12941441	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00057	Wnt signaling pathway	P01461	FrzB	MACMU|Ensembl=ENSMMUG00000014396|UniProtKB=F7BWZ1	Secreted frizzled-related protein 3	ISS	9118218	PubMed	PTHR11309:SF97	SECRETED FRIZZLED-RELATED PROTEIN 3
P00052	TGF-beta signaling pathway	P01288	FKBP12	MACMU|Ensembl=ENSMMUG00000012341|UniProtKB=F7EP21	Peptidyl-prolyl cis-trans isomerase	ISS			PTHR10516:SF309	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1B
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	CANLF|Ensembl=ENSCAFG00000005766|UniProtKB=F1PNW4	Uncharacterized protein	ISS	11438518	PubMed	PTHR10024:SF239	SYNAPTOTAGMIN-1
P00038	JAK/STAT signaling pathway	P01027	STAT	MOUSE|MGI=MGI=103034|UniProtKB=P52633	Signal transducer and transcription activator 6	ISS	14598258	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00049	Parkinson disease	P01211	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MACMU|Ensembl=ENSMMUG00000022347|UniProtKB=F6ZCH5	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00036	Interleukin signaling pathway	P00964	p90RSK	PANTR|Ensembl=ENSPTRG00000000387|UniProtKB=H2PYE3	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00005	Angiogenesis	P00203	Erk	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	ISS			PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04665	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01414	PLC-gamma	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	BOVIN|Ensembl=ENSBTAG00000004775|UniProtKB=F1MBY1	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00029	Huntington disease	P00807	Actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	IDA	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00059	p53 pathway	G04694	p110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00949	Shc	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	IPI	7680960	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00006	Apoptosis signaling pathway	P00296	DAXX	HUMAN|HGNC=2681|UniProtKB=Q9UER7	Death domain-associated protein 6	IDA	10698492	PubMed	PTHR12766:SF7	DEATH DOMAIN-ASSOCIATED PROTEIN 6
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ORYSJ|EnsemblGenome=OS12G0163700|UniProtKB=Q0IPW3	Os12g0163700 protein	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00036	Interleukin signaling pathway	P00967	c-fos	PANTR|Ensembl=ENSPTRG00000006553|UniProtKB=A5A6H0	C-fos	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00057	Wnt signaling pathway	P01456	beta-arrestin	MOUSE|MGI=MGI=99473|UniProtKB=Q8BWG8	Beta-arrestin-1	ISS	9388255	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00046	Oxidative stress response	P01135	p38	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00010	B cell activation	P00379	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P02746	Heme biosynthesis	P02983	Hydroxymethylbilane synthase	DEIRA|EnsemblGenome=DR_2352|UniProtKB=Q9RRY0	Porphobilinogen deaminase	ISS			PTHR11557:SF0	PORPHOBILINOGEN DEAMINASE
P00011	Blood coagulation	P00450	Tissue Factor	BOVIN|Ensembl=ENSBTAG00000007101|UniProtKB=P30931	Tissue factor	ISS	401175	gi	PTHR20859:SF22	TISSUE FACTOR
P00034	Integrin signalling pathway	P00940	Src	CANLF|Ensembl=ENSCAFG00000008755|UniProtKB=E2RSH8	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	TAS	9603989	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00056	VEGF signaling pathway	P01407	Erk	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00029	Huntington disease	P00778	NMDA receptor	MOUSE|MGI=MGI=95823|UniProtKB=Q03391	Glutamate receptor ionotropic, NMDA 2D	IDA	11319238	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MONDO|Ensembl=ENSMODG00000020977|UniProtKB=F6S5B1	Uncharacterized protein (Fragment)	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00029	Huntington disease	P00807	Actin	DROME|FlyBase=FBgn0000045|UniProtKB=P02574	Actin, larval muscle	IDA	11889126	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P05917	Opioid proopiomelanocortin pathway	P06008	ACTH	MACMU|Ensembl=ENSMMUG00000016463|UniProtKB=F7GBI0	Uncharacterized protein	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DANRE|ZFIN=ZDB-GENE-040426-1178|UniProtKB=Q7SY24	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00025	Hedgehog signaling pathway	P00682	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	10693759	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01407	Erk	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00056	VEGF signaling pathway	P01407	Erk	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00056	VEGF signaling pathway	P01417	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P04393	Ras Pathway	P04546	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	IDA	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00018	EGF receptor signaling pathway	P00554	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	7798194	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	LEIMA|EnsemblGenome=LmjF.21.1250|UniProtKB=Q4QC71	Putative adenylate kinase	ISS			PTHR23359:SF81	ADENYLATE KINASE 2, CHLOROPLASTIC
P00056	VEGF signaling pathway	P01418	Paxillin	XENTR|Xenbase=XB-GENE-941407|UniProtKB=F7B727	Peroxidasin	ISS	7579684	PubMed	PTHR24216:SF11	PAXILLIN
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	MACMU|Ensembl=ENSMMUG00000004046|UniProtKB=F6ZR77	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00037	Ionotropic glutamate receptor pathway	P01026	KA	PANTR|Ensembl=ENSPTRG00000011042|UniProtKB=H2QGF5	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	G04694	p110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P01485	p53	MOUSE|MGI=MGI=98834|UniProtKB=P02340	Cellular tumor antigen p53	TAS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	HUMAN|HGNC=1954|UniProtKB=P08912	Muscarinic acetylcholine receptor M5	TAS	8100450	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	DANRE|ZFIN=ZDB-GENE-070705-73|UniProtKB=B8A561	Uncharacterized protein	ISS			PTHR13140:SF676	MYOSIN, HEAVY POLYPEPTIDE 2, FAST MUSCLE SPECIFIC
P00029	Huntington disease	P00807	Actin	RAT|RGD=1304556|UniProtKB=P63259	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	MACMU|Ensembl=ENSMMUG00000010184|UniProtKB=F6SR09	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00048	PI3 kinase pathway	P01199	Galpha	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00056	VEGF signaling pathway	P01411	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	P01444	Wnt	MACMU|Ensembl=ENSMMUG00000017346|UniProtKB=F7H9B8	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P00056	VEGF signaling pathway	P01408	Akt/PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	CAEEL|WormBase=WBGene00001679|UniProtKB=P17343	Guanine nucleotide-binding protein subunit beta-1	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00034	Integrin signalling pathway	P00944	Actin	MONDO|Ensembl=ENSMODG00000002647|UniProtKB=F7DIB7	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00021	FGF signaling pathway	P00641	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHICK|Ensembl=ENSGALG00000011086|UniProtKB=P68139	Actin, alpha skeletal muscle	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	IDA	8838325	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00019	Endothelin signaling pathway	P00566	ERK	ARATH|TAIR=AT4G36450|UniProtKB=O23236	Mitogen-activated protein kinase 14	ISS			PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P02768	Proline biosynthesis	P03112	Glutamate semialdehyde dehydrogenase	DEIRA|EnsemblGenome=DR_1826|UniProtKB=Q9RTD9	Gamma-glutamyl phosphate reductase	ISS			PTHR11063:SF8	DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE
P00010	B cell activation	P00392	I kappa B	MACMU|Ensembl=ENSMMUG00000020374|UniProtKB=F6UMS2	NF-kappa-B inhibitor alpha	ISS	14665694	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00021	FGF signaling pathway	P00642	MEK1-2	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	ISS	7925653	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00025	Hedgehog signaling pathway	P00692	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00059	p53 pathway	P01486	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MACMU|Ensembl=ENSMMUG00000023046|UniProtKB=F6V829	Uncharacterized protein	ISS			PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P02728	Arginine biosynthesis	P02846	Ornithine carbamoyl transferase	PSEAE|EnsemblGenome=PA3537|UniProtKB=P11724	Ornithine carbamoyltransferase	ISS			PTHR11405:SF1	ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DROME|FlyBase=FBgn0261854|UniProtKB=A1Z9X0	Atypical protein kinase C	IC	15572354	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00006	Apoptosis signaling pathway	P00297	NFkappaB	PANTR|Ensembl=ENSPTRG00000002888|UniProtKB=H2Q2H2	Uncharacterized protein	ISS	12574369	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P06587	Nicotine pharmacodynamics pathway	P06611	CLIC6	RAT|RGD=727938|UniProtKB=Q811Q2	Chloride intracellular channel protein 6	IDA	14499480	PubMed	PTHR45476:SF1	CHLORIDE INTRACELLULAR CHANNEL PROTEIN 6
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IGI	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05915	Opioid proenkephalin pathway	P05990	K+ channel	MOUSE|MGI=MGI=3521816|UniProtKB=Q3LS21	Potassium channel subfamily K member 9	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00019	Endothelin signaling pathway	P00591	PLCbeta	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IPI	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00141	Membrane metalloprotease	HUMAN|HGNC=7161|UniProtKB=P51511	Matrix metalloproteinase-15	TAS	12834808	PubMed	PTHR10201:SF25	MATRIX METALLOPROTEINASE-15
P00005	Angiogenesis	P00251	cPLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	IDA	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00050	Plasminogen activating cascade	P01262	pro-uPA	MOUSE|MGI=MGI=97611|UniProtKB=P06869	Urokinase-type plasminogen activator	IGI	6679377	gi	PTHR24264:SF38	UROKINASE-TYPE PLASMINOGEN ACTIVATOR
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00054	Toll receptor signaling pathway	P01351	TLR2,4,7	CHICK|Gene=TLR2-1|UniProtKB=Q9DD78	Toll-like receptor 2 type-1	ISS			PTHR24365:SF17	TOLL-LIKE RECEPTOR 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	HUMAN|HGNC=10627|UniProtKB=P10147	C-C motif chemokine 3	ISS			PTHR12015:SF91	C-C MOTIF CHEMOKINE 3-RELATED
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	MOUSE|MGI=MGI=1931052|UniProtKB=A6ZI47	Fructose-bisphosphate aldolase	ISS	74094688	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P05913	Enkephalin release	P05972	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	10074940	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DICPU|Gene=DICPUDRAFT_90232|UniProtKB=F1A175	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04393	Ras Pathway	P04542	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00057	Wnt signaling pathway	P01452	NFAT	MOUSE|MGI=MGI=103296|UniProtKB=P97305	Nuclear factor of activated T-cells, cytoplasmic 3	IDA	9462517	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00034	Integrin signalling pathway	P00947	Laminin	BOVIN|Ensembl=ENSBTAG00000022635|UniProtKB=E1BDK6	Uncharacterized protein	ISS	2538453	PubMed	PTHR10574:SF36	LAMININ SUBUNIT BETA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	BOVIN|Ensembl=ENSBTAG00000016138|UniProtKB=P01217	Glycoprotein hormones alpha chain	ISS	15927770	PubMed	PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00021	FGF signaling pathway	P00632	Akt	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	IGI	12089061	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	XENTR|Xenbase=XB-GENE-961282|UniProtKB=Q6DF43	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00057	Wnt signaling pathway	P01434	sFRP	MOUSE|MGI=MGI=892014|UniProtKB=Q8C4U3	Secreted frizzled-related protein 1	ISS	9096311	PubMed	PTHR11309:SF87	SECRETED FRIZZLED-RELATED PROTEIN 1
P04393	Ras Pathway	P04550	Ral	MOUSE|MGI=MGI=1927244|UniProtKB=Q9JIW9	Ras-related protein Ral-B	ISS	12856001	PubMed	PTHR24070:SF199	RAS-RELATED PROTEIN RAL-B
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	MACMU|Ensembl=ENSMMUG00000020525|UniProtKB=F6R4X7	Uncharacterized protein	ISS			PTHR43311:SF2	GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED
P00047	PDGF signaling pathway	P01145	c-fos	RAT|RGD=2626|UniProtKB=P12841	Proto-oncogene c-Fos	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00014	Cholesterol biosynthesis	P00499	Farnesyl-diphosphate farnesyltransferase	ARATH|TAIR=AT4G34650|UniProtKB=O65688	Putative squalene synthase	ISS			PTHR11626:SF2	SQUALENE SYNTHASE
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P02783	Tryptophan biosynthesis	P03209	Anthranilate phosphoribosyl transferase	BACSU|EnsemblGenome=BSU00750|UniProtKB=P28819	Aminodeoxychorismate/anthranilate synthase component 2	ISS			PTHR43418:SF4	MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN
P00018	EGF receptor signaling pathway	P00558	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	HUMAN|HGNC=6857|UniProtKB=Q99683	Mitogen-activated protein kinase kinase kinase 5	IGI	12566458	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00030	Hypoxia response via HIF activation	P00819	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00376	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00029	Huntington disease	P00807	Actin	CAEBR|Gene=CBG18256|UniProtKB=A8XS95	Protein CBR-ACT-5	ISS	10974003	PubMed	PTHR11937:SF352	ACTIN
P05912	Dopamine receptor mediated signaling pathway	P05957	K+ channel	BOVIN|Ensembl=ENSBTAG00000047488|UniProtKB=G3N1D1	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00034	Integrin signalling pathway	P00917	ELMO	HUMAN|HGNC=17233|UniProtKB=Q96JJ3	Engulfment and cell motility protein 2	ISS	12879077	PubMed	PTHR12771:SF8	ENGULFMENT AND CELL MOTILITY PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00047	PDGF signaling pathway	P01142	p90RSK	MACMU|Ensembl=ENSMMUG00000002134|UniProtKB=F6UNV6	Ribosomal protein S6 kinase	ISS	2779569	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P04393	Ras Pathway	P04553	PAK	XENTR|Xenbase=XB-GENE-961764|UniProtKB=F6W3Y0	Uncharacterized protein	ISS	11259591	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P04376	5HT4 type receptor mediated signaling pathway	P04426	K+ channel	DANRE|ZFIN=ZDB-GENE-040724-171|UniProtKB=Q5TZ59	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00030	Hypoxia response via HIF activation	P00819	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00960	PTP	MOUSE|MGI=MGI=99511|UniProtKB=P35235	Tyrosine-protein phosphatase non-receptor type 11	TAS	14525967	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00029	Huntington disease	P00795	BDNF	MOUSE|MGI=MGI=88145|UniProtKB=P21237	Brain-derived neurotrophic factor	ISS	11724916	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	MOUSE|MGI=MGI=105052|UniProtKB=O09030	Interleukin-13 receptor subunit alpha-1	ISS			PTHR23036:SF89	INTERLEUKIN-13 RECEPTOR SUBUNIT ALPHA-1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00015	Circadian clock system	G01501	cry	PANTR|Ensembl=ENSPTRG00000005396|UniProtKB=H2Q6S7	Cryptochrome 1 (Photolyase-like)	ISS	10428031	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	PYRAE|EnsemblGenome=PAE2474|UniProtKB=Q8ZV36	Acetyl-coenzyme A synthetase	ISS			PTHR24095:SF232	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01177	P110ACT	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	XENTR|Xenbase=XB-GENE-494200|UniProtKB=F7CS79	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00059	p53 pathway	P01486	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P06959	CCKR signaling map	P07119	MAPK3	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	RCA	9230117	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00058	mRNA splicing	P01476	U4	CAEBR|Gene=CBG12355|UniProtKB=A8XF84	Protein CBR-PRP-4	ISS	11099033	PubMed	PTHR19846:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP4
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	MOUSE|MGI=MGI=1913284|UniProtKB=O35593	26S proteasome non-ATPase regulatory subunit 14	ISS	9727008	PubMed	PTHR10410:SF5	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	TAS	22081553	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02721	ATP synthesis	P02798	Cyt C	MOUSE|MGI=MGI=88578|UniProtKB=P62897	Cytochrome c, somatic	TAS	11836241	PubMed	PTHR11961:SF15	CYTOCHROME C
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00010	B cell activation	P00380	fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	TAS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04397	p53 pathway by glucose deprivation	P04637	4E-BP1	PANTR|Ensembl=ENSPTRG00000022700|UniProtKB=H2R0Z1	Uncharacterized protein	ISS	12820960	PubMed	PTHR12669:SF14	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1
P00019	Endothelin signaling pathway	P00587	Raf-1	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS			PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00047	PDGF signaling pathway	P01161	Raf	MOUSE|MGI=MGI=88190|UniProtKB=P28028	Serine/threonine-protein kinase B-raf	ISS	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	TAS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04393	Ras Pathway	P04570	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01203	p101	HUMAN|HGNC=30035|UniProtKB=Q8WYR1	Phosphoinositide 3-kinase regulatory subunit 5	IGI	12507995	PubMed	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00018	EGF receptor signaling pathway	P00546	GAP	MACMU|Ensembl=ENSMMUG00000009418|UniProtKB=F6X9K0	Uncharacterized protein	ISS	20475167	gi	PTHR10194:SF21	RAS GTPASE-ACTIVATING PROTEIN 2
P00057	Wnt signaling pathway	P01429	Axin	PANTR|Ensembl=ENSPTRG00000007537|UniProtKB=H2R1H5	Uncharacterized protein	ISS	12356903	PubMed	PTHR10845:SF11	AXIN-1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	DROME|FlyBase=FBgn0005590|UniProtKB=P54631	Protein screw	IGI	7958918	PubMed	PTHR11848:SF54	PROTEIN 60A-RELATED
P00010	B cell activation	P00380	fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	TAS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	ORYSJ|EnsemblGenome=OS11G0171300|UniProtKB=Q40677	Fructose-bisphosphate aldolase, chloroplastic	TAS	8163192	PubMed	PTHR11627:SF16	SUBFAMILY NOT NAMED
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00049	Parkinson disease	P01233	Elk-1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	IDA	3183861	gi	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	MOUSE|MGI=MGI=95794|UniProtKB=A2ARV4	Low-density lipoprotein receptor-related protein 2	ISS	11907044	PubMed	PTHR44025:SF5	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00047	PDGF signaling pathway	P01145	c-fos	RAT|RGD=2626|UniProtKB=P12841	Proto-oncogene c-Fos	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	TAS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00566	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CAEBR|Gene=CBG02401|UniProtKB=A8WUE7	Protein CBR-NMR-1	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	BOVIN|Ensembl=ENSBTAG00000006495|UniProtKB=P11017	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04612	HDAC1	RAT|RGD=1309799|UniProtKB=Q4QQW4	Histone deacetylase 1	ISS	12665570	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P00056	VEGF signaling pathway	P01407	Erk	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02775	Salvage pyrimidine ribonucleotides	P03156	CDP kinase	HUMAN|HGNC=7850|UniProtKB=P22392	Nucleoside diphosphate kinase B	ISS			PTHR11349:SF57	NUCLEOSIDE DIPHOSPHATE KINASE B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	XENTR|Xenbase=XB-GENE-490883|UniProtKB=Q6NVA9	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	20331588	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00045	Notch signaling pathway	P01103	Next	MACMU|Ensembl=ENSMMUG00000017022|UniProtKB=F7HQZ9	Uncharacterized protein	ISS	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	TAS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00021	FGF signaling pathway	P00629	PP2A	IXOSC|EnsemblGenome=ISCW014549|UniProtKB=B7QGY5	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00004	Alzheimer disease-presenilin pathway	P00139	E-cadherin transmembrane fragment	MACMU|Ensembl=ENSMMUG00000010393|UniProtKB=F7D992	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P00056	VEGF signaling pathway	P01417	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	3449797	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00020	FAS signaling pathway	P00615	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00056	VEGF signaling pathway	P01413	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00570	PKA	EMENI|EnsemblGenome=CADANIAG00005408|UniProtKB=O59922	cAMP-dependent protein kinase regulatory subunit	ISS	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IDA	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	TRYB2|Gene=Tb11.01.5300|UniProtKB=Q382G4	Ornithine decarboxylase	ISS			PTHR11482:SF6	ORNITHINE DECARBOXYLASE 1-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	IC	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00056	VEGF signaling pathway	P01425	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00254	GTPase	TAKRU|Ensembl=ENSTRUG00000011944|UniProtKB=H2TZX5	Uncharacterized protein	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00011	Blood coagulation	P00460	FXI	RAT|RGD=1309364|UniProtKB=A0A0G2K4I9	Protein F11	ISS	13811665	gi	PTHR44459:SF1	COAGULATION FACTOR XI
P00050	Plasminogen activating cascade	P01264	alpha2 antiplasmin	HUMAN|HGNC=9075|UniProtKB=P08697	Alpha-2-antiplasmin	ISS	11386143	gi	PTHR11461:SF20	ALPHA-2-ANTIPLASMIN
P00021	FGF signaling pathway	P00644	p38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CHICK|Ensembl=ENSGALG00000004083|UniProtKB=Q90855	AMPA receptor GluR1/A	ISS	10331083	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00012	Cadherin signaling pathway	P00470	F-actin	HUMAN|HGNC=145|UniProtKB=P63267	Actin, gamma-enteric smooth muscle	IC	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00014	Cholesterol biosynthesis	P00493	Geranyl trans-transferase	SCHPO|PomBase=SPAC6F12.13c|UniProtKB=O14230	Farnesyl pyrophosphate synthase	ISS	O64905	SPACC	PTHR11525:SF0	FARNESYL PYROPHOSPHATE SYNTHASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05915	Opioid proenkephalin pathway	P05994	G-protein	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00011	Blood coagulation	P00458	GP IIIa	BOVIN|Ensembl=ENSBTAG00000009987|UniProtKB=F1MTN1	Integrin beta	ISS	7949057	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00036	Interleukin signaling pathway	P00973	PKB	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	G01511	SPRY	DANRE|ZFIN=ZDB-GENE-010803-2|UniProtKB=F1QZW4	Uncharacterized protein	IGI	21384945	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00006	Apoptosis signaling pathway	P00271	Bax	HUMAN|HGNC=959|UniProtKB=Q07812	Apoptosis regulator BAX	ISS	8358790	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	PANTR|Ensembl=ENSPTRG00000002979|UniProtKB=H2Q2M8	Uncharacterized protein	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	MOUSE|MGI=MGI=2447811|UniProtKB=A6ZI46	Fructose-bisphosphate aldolase	ISS	84261525	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00025	Hedgehog signaling pathway	P00692	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	TAKRU|Ensembl=ENSTRUG00000005961|UniProtKB=H2SQ04	Uncharacterized protein	ISS			PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	MYCTU|EnsemblGenome=Rv2445c|UniProtKB=P9WJH7	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00021	FGF signaling pathway	P00640	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00775	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P02746	Heme biosynthesis	P02970	Coproporphyrinogen oxidase (oxygen independent)	HUMAN|HGNC=25634|UniProtKB=Q9HA92	Radical S-adenosyl methionine domain-containing protein 1, mitochondrial	ISS			PTHR13932:SF14	RADICAL S-ADENOSYL METHIONINE DOMAIN-CONTAINING PROTEIN 1, MITOCHONDRIAL
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05912	Dopamine receptor mediated signaling pathway	P05949	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8235613	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P02777	Succinate to proprionate conversion	P03161	Methylmalonyl-CoA mutase	STRCO|Gene=CAB92663|UniProtKB=Q9KY64	Isobutiryl CoA mutase, small subunit	ISS			PTHR23408:SF19	SUBFAMILY NOT NAMED
P00059	p53 pathway	G01579	PTEN	CAEEL|WormBase=WBGene00000913|UniProtKB=G5EE01	DAF-18	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000002674|UniProtKB=P02698	Guanine nucleotide-binding protein G(T) subunit gamma-T1	IDA	3100519	PubMed	PTHR13809:SF26	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT GAMMA-T1
P00020	FAS signaling pathway	P00594	Caspase8	RAT|RGD=620945|UniProtKB=Q9JHX4	Caspase-8	IGI	11788820	PubMed	PTHR10454:SF162	CASPASE-8
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CHICK|Ensembl=ENSGALG00000000168|UniProtKB=P49892	Adenosine receptor A1	IDA	12515326	PubMed	PTHR24246:SF1	ADENOSINE RECEPTOR A1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	ORNAN|Ensembl=ENSOANG00000007724|UniProtKB=F6QTB5	Uncharacterized protein	ISS	12473693	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00021	FGF signaling pathway	P00645	Rac	DICPU|Gene=DICPUDRAFT_168754|UniProtKB=F0ZQR3	Rac1B, RHO family GTPase	ISS	94124042	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	HUMAN|HGNC=9509|UniProtKB=P49810	Presenilin-2	IDA	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00053	T cell activation	P01307	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04373	5HT1 type receptor mediated signaling pathway	P04407	K+ channel	HUMAN|HGNC=6278|UniProtKB=O14649	Potassium channel subfamily K member 3	ISS	11875121	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00029	Huntington disease	P00774	Dynein complex	BOVIN|Ensembl=ENSBTAG00000032979|UniProtKB=F1ME41	Uncharacterized protein	ISS	9454836	PubMed	PTHR11886:SF52	DYNEIN LIGHT CHAIN 1, CYTOPLASMIC
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PANTR|Ensembl=ENSPTRG00000009878|UniProtKB=H2QEA0	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P02742	Tetrahydrofolate biosynthesis	P02944	Phosphoribosylglycinamide formyltransferase	BACSU|EnsemblGenome=BSU13110|UniProtKB=O34990	Formyltetrahydrofolate deformylase	ISS			PTHR42706:SF1	FORMYLTETRAHYDROFOLATE DEFORMYLASE 1, MITOCHONDRIAL-RELATED
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MOUSE|MGI=MGI=87904|UniProtKB=P60710	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00021	FGF signaling pathway	P00642	MEK1-2	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00010	B cell activation	P00390	Blk	MOUSE|MGI=MGI=103265|UniProtKB=Q922K9	Tyrosine-protein kinase FRK	IDA			PTHR24418:SF296	TYROSINE-PROTEIN KINASE FRK
P00049	Parkinson disease	P01208	Hsp70	LEIMA|EnsemblGenome=LmjF.30.2550|UniProtKB=Q4Q740	Putative heat shock 70-related protein 1,mitochondrial	IDA	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00036	Interleukin signaling pathway	P00990	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000003043|UniProtKB=P63212	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	HUMAN|HGNC=4039|UniProtKB=Q9ULW2	Frizzled-10	TAS	11212302	PubMed	PTHR11309:SF86	FRIZZLED-10
P00047	PDGF signaling pathway	P01153	GSK3	CAEBR|Gene=CBG07560|UniProtKB=A8X4K1	Protein CBG07560	ISS			PTHR24057:SF20	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MOUSE|MGI=MGI=1343142|UniProtKB=Q9WV32	Actin-related protein 2/3 complex subunit 1B	ISS	9618202	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00050	Plasminogen activating cascade	P01255	Plasminogen	MACMU|Gene=PLG|UniProtKB=P12545	Plasminogen	ISS	130317	gi	PTHR24261:SF6	PLASMINOGEN
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00053	T cell activation	P01295	vav	RAT|RGD=1306285|UniProtKB=D3ZYG0	Protein Vav2	ISS	14623913	PubMed	PTHR22826:SF95	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_115291|UniProtKB=C3ZMR2	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF359	SUBFAMILY NOT NAMED
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	MACMU|Ensembl=ENSMMUG00000014334|UniProtKB=F7CYY6	Uncharacterized protein	ISS	2137198	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	MONDO|Ensembl=ENSMODG00000012981|UniProtKB=F7CS91	Uncharacterized protein	ISS	11360179	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00056	VEGF signaling pathway	P01417	Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P02734	Chorismate biosynthesis	P02872	3-Dehydroquinate synthase	STRCO|EnsemblGenome=CAB93374|UniProtKB=Q9KXQ6	3-dehydroquinate synthase	ISS			PTHR43622:SF1	3-DEHYDROQUINATE SYNTHASE
P00005	Angiogenesis	P00221	JNK1	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00205	GAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	2842690	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	BOVIN|Gene=MYH7|UniProtKB=Q9BE39	Myosin-7	ISS	89264452	PubMed	PTHR13140:SF344	MYOSIN-7
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000017387|UniProtKB=E2RLD1	Uncharacterized protein	ISS	12507995	PubMed	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00057	Wnt signaling pathway	P01440	Cadherin	CHICK|Ensembl=ENSGALG00000015132|UniProtKB=P10288	Cadherin-2	IDA	8120095	PubMed	PTHR24027:SF79	CADHERIN-2
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	XENTR|Xenbase=XB-GENE-957124|UniProtKB=F7BDN8	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00006	Apoptosis signaling pathway	P00294	RAIDD	PANTR|Ensembl=ENSPTRG00000005300|UniProtKB=H2Q6M0	CASP2 and RIPK1 domain containing adaptor with death domain	ISS	8985253	PubMed	PTHR15034:SF5	DEATH DOMAIN-CONTAINING PROTEIN CRADD
P00018	EGF receptor signaling pathway	P00561	STAT	MOUSE|MGI=MGI=103035|UniProtKB=P42232	Signal transducer and activator of transcription 5B	IGI	14662325	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00019	Endothelin signaling pathway	P00583	cPLA2	MONDO|Ensembl=ENSMODG00000011791|UniProtKB=F7CBU9	Phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04398	p53 pathway feedback loops 2	P04658	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00047	PDGF signaling pathway	P01160	IP3 receptor	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00023	General transcription regulation	P00658	TBP-associated factors	MACMU|Ensembl=ENSMMUG00000021715|UniProtKB=F7EWA2	Transcription initiation factor TFIID subunit 11	ISS			PTHR13218:SF16	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11
P05913	Enkephalin release	P05976	Enkephalin	HUMAN|HGNC=8820|UniProtKB=P01213	Proenkephalin-B	ISS	131330	OMIM	PTHR11438:SF4	PROENKEPHALIN-B
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P06664	Gonadotropin-releasing hormone receptor pathway	P06771	Vinculin	MOUSE|MGI=MGI=98927|UniProtKB=Q64727	Vinculin	RCA	14702644	PubMed	PTHR18914:SF1	VINCULIN
P00012	Cadherin signaling pathway	P00466	EGFR	BOVIN|Ensembl=ENSBTAG00000010444|UniProtKB=A6QR62	ERBB3 protein	ISS	20477399	gi	PTHR24416:SF88	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02747	Histidine biosynthesis	P02985	Histidinol dehydrogenase	BACSU|EnsemblGenome=BSU34910|UniProtKB=O34651	Histidinol dehydrogenase	ISS			PTHR21256:SF2	HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00892	Grb2	DROME|FlyBase=FBgn0004638|UniProtKB=Q08012	Protein enhancer of sevenless 2B	ISS	51702266	gi	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00056	VEGF signaling pathway	P01423	p38MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01447	Dishevelled	CANLF|Ensembl=ENSCAFG00000019275|UniProtKB=E2QY91	Uncharacterized protein	ISS	7906389	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05915	Opioid proenkephalin pathway	P05994	G-protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P02738	De novo purine biosynthesis	P02904	Guanylate kinase	BOVIN|Ensembl=ENSBTAG00000014775|UniProtKB=P46195	Guanylate kinase	ISS			PTHR23117:SF13	GUANYLATE KINASE
P00005	Angiogenesis	P00221	JNK1	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MOUSE|MGI=MGI=99677|UniProtKB=O88444	Adenylate cyclase type 1	ISS	89298382	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	HUMAN|HGNC=11640|UniProtKB=Q9HCS4	Transcription factor 7-like 1	IEP	9118222	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P02743	Formyltetrahydroformate biosynthesis	P02956	Formyl tetrahydrofolate deformylase	MYCTU|EnsemblGenome=Rv2964|UniProtKB=P9WHM3	Formyltetrahydrofolate deformylase	ISS			PTHR42706:SF1	FORMYLTETRAHYDROFOLATE DEFORMYLASE 1, MITOCHONDRIAL-RELATED
P00005	Angiogenesis	P00211	GSK3beta	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IDA	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IGI	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00923	Arf1	BOVIN|Ensembl=ENSBTAG00000007725|UniProtKB=P84080	ADP-ribosylation factor 1	ISS	12932731	PubMed	PTHR11711:SF294	ADP-RIBOSYLATION FACTOR 3
P00018	EGF receptor signaling pathway	P00552	Ras	MACMU|Ensembl=ENSMMUG00000028733|UniProtKB=F6ZGX8	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF245	RAS-RELATED PROTEIN R-RAS
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00048	PI3 kinase pathway	P01176	JAK	RAT|RGD=2939|UniProtKB=Q62689	Tyrosine-protein kinase JAK2	ISS	22482294	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DANRE|ZFIN=ZDB-GENE-000329-3|UniProtKB=Q7ZVF9	Actin, cytoplasmic 2	ISS	3487386	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00029	Huntington disease	P00807	Actin	RAT|RGD=2027|UniProtKB=P63269	Actin, gamma-enteric smooth muscle	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00053	T cell activation	P01332	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04665	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00589	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IGI	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00313	IKK	DROME|FlyBase=FBgn0024222|UniProtKB=Q9VEZ5	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS			PTHR22969:SF15	FI05319P-RELATED
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	TAS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	IC	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00010	B cell activation	P00391	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02725	Allantoin degradation	P02821	Allantoate amidohydrolase	XENTR|Xenbase=XB-GENE-1002643|UniProtKB=Q640T1	Allantoicase	ISS			PTHR12045:SF3	ALLANTOICASE-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	TAKRU|Ensembl=ENSTRUG00000011297|UniProtKB=H2TV18	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00048	PI3 kinase pathway	P01199	Galpha	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	IC	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	DANRE|ZFIN=ZDB-GENE-991119-4|UniProtKB=Q9W6T7	Presenilin-1	TAS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00030	Hypoxia response via HIF activation	P00814	P300	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00048	PI3 kinase pathway	P01205	NOS	MOUSE|MGI=MGI=97362|UniProtKB=P70313	Nitric oxide synthase, endothelial	ISS	10435050	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	IXOSC|EnsemblGenome=ISCW003614|UniProtKB=B7PHY7	Cdc42 protein, putative	ISS	12932731	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00057	Wnt signaling pathway	P01456	beta-arrestin	ANOGA|Gene=AgaP_AGAP011360|UniProtKB=Q7Q2V9	AGAP011360-PA (Fragment)	IDA	4757780	gi	PTHR11792:SF17	KURTZ ARRESTIN
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	LEIMA|EnsemblGenome=LmjF.21.1860|UniProtKB=Q4QBZ6	Beta tubulin	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	HUMAN|HGNC=1401|UniProtKB=Q02641	Voltage-dependent L-type calcium channel subunit beta-1	IC	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00047	PDGF signaling pathway	P01154	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01336	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000002647|UniProtKB=F7DIB7	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000000365|UniProtKB=F6R9F4	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04393	Ras Pathway	P04542	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	CHLTR|EnsemblGenome=CT_500|UniProtKB=O84508	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MOUSE|MGI=MGI=109248|UniProtKB=Q920H4	Muscarinic acetylcholine receptor M5	IDA	12181435	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00010	B cell activation	P00372	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12162872	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00056	VEGF signaling pathway	P01414	PLC-gamma	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P02738	De novo purine biosynthesis	P02909	GDP reductase	DEIRA|EnsemblGenome=DR_B0108|UniProtKB=Q9RZL7	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT ALPHA
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P02744	Fructose galactose metabolism	P02960	Galactokinase	PANTR|Ensembl=ENSPTRG00000009654|UniProtKB=H2QDW0	Uncharacterized protein	ISS	12003984	gi	PTHR10457:SF6	GALACTOKINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	CHICK|Ensembl=ENSGALG00000001383|UniProtKB=F1NJL4	Uncharacterized protein	ISS	12181435	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000002658|UniProtKB=F7CB14	Uncharacterized protein	ISS	2137198	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TAKRU|Ensembl=ENSTRUG00000004787|UniProtKB=P53480	Actin, alpha cardiac	ISS	14684598	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00034	Integrin signalling pathway	P00924	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	IPI	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P05913	Enkephalin release	P05976	Enkephalin	MACMU|Ensembl=ENSMMUG00000006775|UniProtKB=F7H3N8	Uncharacterized protein	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PANTR|Ensembl=ENSPTRG00000008496|UniProtKB=H2QBS3	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DANRE|ZFIN=ZDB-GENE-000329-1|UniProtKB=Q7ZVI7	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00057	Wnt signaling pathway	P01432	Beta-Catenin	MOUSE|MGI=MGI=88276|UniProtKB=Q02248	Catenin beta-1	IDA	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P00056	VEGF signaling pathway	P01421	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	RCA			PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_115566|UniProtKB=C3XYC8	Putative uncharacterized protein	IDA	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00005	Angiogenesis	P00211	GSK3beta	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00059	p53 pathway	G01579	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P02752	Mannose metabolism	P03019	P-Mannose mutase	CANLF|Ensembl=ENSCAFG00000019010|UniProtKB=E2R832	Phosphomannomutase	ISS	12477932	PubMed	PTHR10466:SF2	PHOSPHOMANNOMUTASE 2
P05731	GABA-B receptor II signaling	P05760	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04393	Ras Pathway	P04558	p38	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	IDA	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	MACMU|Ensembl=ENSMMUG00000017431|UniProtKB=F7HPP3	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	BACSU|EnsemblGenome=BSU11230|UniProtKB=P36838	Carbamoyl-phosphate synthase arginine-specific small chain	ISS			PTHR11405:SF4	CARBAMOYL-PHOSPHATE SYNTHASE ARGININE-SPECIFIC SMALL CHAIN
P00048	PI3 kinase pathway	P01206	14-3-3	MACMU|Ensembl=ENSMMUG00000006489|UniProtKB=F7EFF6	14-3-3 protein zeta/delta	ISS	92283271	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	CANLF|Ensembl=ENSCAFG00000015094|UniProtKB=F1PT97	Uncharacterized protein	ISS	12963527	gi	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00019	Endothelin signaling pathway	P00587	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	XENTR|Xenbase=XB-GENE-6067221|UniProtKB=F6Z0J4	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	SCHPO|PomBase=SPAC8C9.03|UniProtKB=P36600	cAMP-dependent protein kinase regulatory subunit	ISS	2372396	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00968	Ikk	PANTR|Ensembl=ENSPTRG00000020202|UniProtKB=H2QW34	Uncharacterized protein	ISS	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00046	Oxidative stress response	P01137	MNK1/2	RAT|RGD=1559603|UniProtKB=Q4G050	MAP kinase-interacting serine/threonine-protein kinase 1	ISS	97299868	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00925	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	14744428	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DAPPU|EnsemblGenome=DAPPUDRAFT_228751|UniProtKB=E9HGF5	Cytoplasmatic actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00049	Parkinson disease	P01221	Torsin A	BOVIN|Ensembl=ENSBTAG00000020305|UniProtKB=A5PK75	TOR1A protein	ISS	12421356	PubMed	PTHR10760:SF15	TORSIN-1A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01451	Galpha	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	XENTR|Xenbase=XB-GENE-1010483|UniProtKB=F7AF72	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P02738	De novo purine biosynthesis	P02908	Phosphoribosylamine glycine ligase	BACSU|EnsemblGenome=BSU06530|UniProtKB=P12039	Phosphoribosylamine--glycine ligase	ISS			PTHR43472:SF1	PHOSPHORIBOSYLAMINE--GLYCINE LIGASE
P02771	Pyrimidine Metabolism	P03124	Methylmalonate Semialdehyde Dehydrogenase	MACMU|Ensembl=ENSMMUG00000012684|UniProtKB=F7E2B9	Uncharacterized protein	ISS	2708830	gi	PTHR43866:SF3	METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE  ACYLATING , MITOCHONDRIAL
P00029	Huntington disease	P00805	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00807	Actin	MACMU|Ensembl=ENSMMUG00000001353|UniProtKB=F7D6T8	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00010	B cell activation	P00369	MEKK	MACMU|Ensembl=ENSMMUG00000016751|UniProtKB=F7AIB6	Mitogen-activated protein kinase kinase kinase 3 isoform 1	ISS	8649450	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P04398	p53 pathway feedback loops 2	P04649	Myc	MACMU|Ensembl=ENSMMUG00000014601|UniProtKB=B8XIA5	Myc proto-oncogene protein	ISS	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00059	p53 pathway	P04634	Cdc2	CANLF|Ensembl=ENSCAFG00000000082|UniProtKB=E2QW70	Uncharacterized protein	ISS	1846803	PubMed	PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P00054	Toll receptor signaling pathway	P01368	MKK2	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00023	General transcription regulation	P00670	TBP	MONDO|Ensembl=ENSMODG00000017515|UniProtKB=F7F0J5	Uncharacterized protein	ISS	10082669	PubMed	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Gene=PCDHB12|UniProtKB=Q5DRD7	Protocadherin beta-12	ISS	8120095	PubMed	PTHR24028:SF228	PROTOCADHERIN BETA-12
P00010	B cell activation	P00384	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00624	14-3-3	DANRE|ZFIN=ZDB-GENE-050306-44|UniProtKB=Q5CZQ1	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2	ISS	8024705	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	XENTR|Xenbase=XB-GENE-482409|UniProtKB=F6UK84	Uncharacterized protein (Fragment)	ISS	15116068	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01026	KA	XENTR|Xenbase=XB-GENE-957124|UniProtKB=F7BDN8	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04393	Ras Pathway	P04570	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02782	Triacylglycerol metabolism	P03205	Triacylglycerol lipase	PANTR|Ensembl=ENSPTRG00000011058|UniProtKB=H2QGG6	Uncharacterized protein	ISS			PTHR23025:SF3	HORMONE-SENSITIVE LIPASE
P05915	Opioid proenkephalin pathway	P05994	G-protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00034	Integrin signalling pathway	P00933	Crk	HUMAN|HGNC=2362|UniProtKB=P46108	Adapter molecule crk	ISS	8649368	PubMed	PTHR19969:SF8	ADAPTER MOLECULE CRK
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	MOUSE|MGI=MGI=87906|UniProtKB=P63260	Actin, cytoplasmic 2	ISS	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00057	Wnt signaling pathway	P01472	Histone deacetylase	MACMU|Ensembl=ENSMMUG00000029538|UniProtKB=F7GAQ3	Uncharacterized protein	ISS	10485845	PubMed	PTHR10625:SF132	HISTONE DEACETYLASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=71083|UniProtKB=P30940	5-hydroxytryptamine receptor 1F	IDA	1608964	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00021	FGF signaling pathway	P00638	PLCgamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00005	Angiogenesis	P00254	GTPase	CHICK|Ensembl=ENSGALG00000001569|UniProtKB=Q9PSX7	Rho-related GTP-binding protein RhoC	ISS	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	PSEAE|EnsemblGenome=PA0298|UniProtKB=Q9I6J3	Probable glutamine synthetase	ISS			PTHR43785:SF3	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00627	ERK1-2	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	NAS	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04384	Gamma-aminobutyric acid synthesis	P04480	GABA aminotransferase	PANTR|Ensembl=ENSPTRG00000007746|UniProtKB=H2QAJ4	4-aminobutyrate aminotransferase	ISS	2496985	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00020	FAS signaling pathway	P00600	PARP	XENTR|Xenbase=XB-GENE-974935|UniProtKB=F6X747	Poly [ADP-ribose] polymerase (Fragment)	ISS	12101391	PubMed	PTHR10459:SF80	POLY  ADP-RIBOSE  POLYMERASE 1
P00046	Oxidative stress response	P01129	JNK1/2	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00036	Interleukin signaling pathway	P00977	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P02723	Adenine and hypoxanthine salvage pathway	P02813	Inosine phosphorylase	MACMU|Ensembl=ENSMMUG00000019126|UniProtKB=F6T0Z6	Purine nucleoside phosphorylase	ISS			PTHR11904:SF12	PURINE NUCLEOSIDE PHOSPHORYLASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00019	Endothelin signaling pathway	P00572	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00053	T cell activation	P01300	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00058	mRNA splicing	P01473	U6	CANLF|Ensembl=ENSCAFG00000011820|UniProtKB=E2R4I0	Uncharacterized protein	ISS	12875835	PubMed	PTHR14212:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00012	Cadherin signaling pathway	P00475	Frizzled	BOVIN|Ensembl=ENSBTAG00000002107|UniProtKB=A7MB15	FZD1 protein	ISS	11212302	PubMed	PTHR11309:SF81	FRIZZLED-1
P00016	Cytoskeletal regulation by Rho GTPase	P00513	Op18/stathmin	BOVIN|Ensembl=ENSBTAG00000017627|UniProtKB=Q0VCK4	Stathmin	ISS			PTHR10104:SF6	STATHMIN-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00059	p53 pathway	G04700	PAI	PANTR|Ensembl=ENSPTRG00000019519|UniProtKB=H2QV47	Uncharacterized protein	ISS	18092159	gi	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	PANTR|Ensembl=ENSPTRG00000019739|UniProtKB=H2QVG0	Uncharacterized protein	RCA			PTHR22952:SF96	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 2
P00049	Parkinson disease	P01239	Cul-1	BOVIN|Ensembl=ENSBTAG00000008736|UniProtKB=F1MYD0	Uncharacterized protein	ISS	12628165	PubMed	PTHR11932:SF81	CULLIN-1
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00036	Interleukin signaling pathway	P00994	FKHRL1	MACMU|Ensembl=ENSMMUG00000020369|UniProtKB=F6UMX8	Uncharacterized protein	ISS	12884295	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00049	Parkinson disease	P01219	SAPK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00054	Toll receptor signaling pathway	P01356	ERK2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04393	Ras Pathway	P04559	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	14564011	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05731	GABA-B receptor II signaling	P05754	Ggamma	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g169611|UniProtKB=A7SEB1	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02738	De novo purine biosynthesis	P02903	Phosphoribosylglycinamide  formyltransferase	STRCO|Gene=CAB92676|UniProtKB=Q9KY51	Phosphoribosylglycinamide formyltransferase	ISS			PTHR43369:SF2	PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE
P04393	Ras Pathway	P04570	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00552	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00006	Apoptosis signaling pathway	P00259	TNF	MOUSE|MGI=MGI=104798|UniProtKB=P06804	Tumor necrosis factor	ISS	11911478	PubMed	PTHR11471:SF23	TUMOR NECROSIS FACTOR
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	BOVIN|Ensembl=ENSBTAG00000037794|UniProtKB=E1BP87	Uncharacterized protein	IC	89264452	PubMed	PTHR13140:SF681	MYOSIN-4
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MONDO|Ensembl=ENSMODG00000012401|UniProtKB=F6PMQ6	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00010	B cell activation	P00391	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	MOUSE|MGI=MGI=102891|UniProtKB=P51829	Adenylate cyclase type 7	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01082	AC	MACMU|Ensembl=ENSMMUG00000010380|UniProtKB=F7D9M6	Uncharacterized protein	ISS	11744988	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00048	PI3 kinase pathway	P01177	P110ACT	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	BOVIN|Ensembl=ENSBTAG00000014447|UniProtKB=A4IFF4	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00020	FAS signaling pathway	P00615	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00775	Rac	DANRE|ZFIN=ZDB-GENE-030131-8783|UniProtKB=Q52WY2	Ras-like protein Cdc42a	ISS			PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00034	Integrin signalling pathway	P00938	Cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01453	Ebi	TAKRU|Ensembl=ENSTRUG00000006095|UniProtKB=H2SQX0	Uncharacterized protein	ISS			PTHR22846:SF40	F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN TBL1XR1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Gene=HTR1D|UniProtKB=P11614	5-hydroxytryptamine receptor 1D	IDA	11701344	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00056	VEGF signaling pathway	P01407	Erk	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=24667|UniProtKB=Q8TD08	Mitogen-activated protein kinase 15	ISS	10851062	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	BOVIN|Ensembl=ENSBTAG00000007964|UniProtKB=Q148J6	Actin-related protein 2/3 complex subunit 4	ISS	5031595	gi	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00005	Angiogenesis	P00190	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04393	Ras Pathway	P04572	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IDA	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00047	PDGF signaling pathway	P01159	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00007	Axon guidance mediated by semaphorins	P00336	Cdk5	TAKRU|Ensembl=ENSTRUG00000004034|UniProtKB=H2SAY8	Uncharacterized protein	ISS	10604473	PubMed	PTHR24056:SF46	CYCLIN-DEPENDENT-LIKE KINASE 5
P00019	Endothelin signaling pathway	P00572	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00052	TGF-beta signaling pathway	P01275	P38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	TAS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00048	PI3 kinase pathway	P01179	PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P05918	p38 MAPK pathway	P06043	ASK1	PANTR|Ensembl=ENSPTRG00000024326|UniProtKB=H2R231	Uncharacterized protein	ISS	11730323	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00010	B cell activation	P00383	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	IDA	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05917	Opioid proopiomelanocortin pathway	P06006	beta-Endorphin	HUMAN|HGNC=9201|UniProtKB=P01189	Pro-opiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00045	Notch signaling pathway	P01115	Neurotic	RAT|RGD=1303001|UniProtKB=Q6EV70	GDP-fucose protein O-fucosyltransferase 1	RCA			PTHR21420:SF3	GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Ensembl=ENSCAFG00000011689|UniProtKB=E2QZY2	Uncharacterized protein	ISS	11259498	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00057	Wnt signaling pathway	P01457	GBeta	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MACMU|Ensembl=ENSMMUG00000012229|UniProtKB=F6VF32	Uncharacterized protein	ISS	22028976	PubMed	PTHR13140:SF387	MYOSIN-IIIA
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01312	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	MONDO|Ensembl=ENSMODG00000009937|UniProtKB=F6R812	Uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00057	Wnt signaling pathway	P01431	LRP5/6	RAT|RGD=1304749|UniProtKB=A0A0G2K0H3	Protein Lrp6	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00054	Toll receptor signaling pathway	P01375	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00029	Huntington disease	P00778	NMDA receptor	MACMU|Ensembl=ENSMMUG00000016675|UniProtKB=F6VTB5	Uncharacterized protein	ISS	11319238	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	RAT|RGD=620465|UniProtKB=O08565	C-X-C chemokine receptor type 4	ISS	4503175	gi	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P00005	Angiogenesis	P00221	JNK1	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	HUMAN|HGNC=7881|UniProtKB=P46531	Neurogenic locus notch homolog protein 1	IDA	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P06959	CCKR signaling map	P07034	CaMKK	HUMAN|HGNC=1469|UniProtKB=Q8N5S9	Calcium/calmodulin-dependent protein kinase kinase 1	RCA	10535305	PubMed	PTHR44035:SF1	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE 1
P00006	Apoptosis signaling pathway	P00302	ATF	CANLF|Ensembl=ENSCAFG00000013332|UniProtKB=F1PCQ4	Uncharacterized protein	ISS	7875593	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02913	Thymidylate synthase	TRYB2|Gene=Tb927.7.5480|UniProtKB=Q582G3	Bifunctional dihydrofolate reductase-thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01082	AC	MACMU|Ensembl=ENSMMUG00000010380|UniProtKB=F7D9M6	Uncharacterized protein	ISS	10915626	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P00057	Wnt signaling pathway	P01444	Wnt	BRAFL|Gene=BRAFLDRAFT_113720|UniProtKB=C3YYJ8	Protein Wnt	IDA	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=1951|UniProtKB=P08172	Muscarinic acetylcholine receptor M2	IDA	11166329	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00056	VEGF signaling pathway	P01414	PLC-gamma	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	PANTR|Ensembl=ENSPTRG00000001791|UniProtKB=H2R8B2	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF32	REGULATOR OF G-PROTEIN SIGNALING 13
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00052	TGF-beta signaling pathway	P01275	P38	CAEEL|WormBase=WBGene00004056|UniProtKB=Q8MXI4	Mitogen-activated protein kinase pmk-2	TAS	10851062	PubMed	PTHR24055:SF154	MITOGEN-ACTIVATED PROTEIN KINASE PMK-2
P00014	Cholesterol biosynthesis	P00491	Hydroxymethyl glutaryl CoA reductase	RAT|RGD=2803|UniProtKB=P51639	3-hydroxy-3-methylglutaryl-coenzyme A reductase	ISS	P00347	SPACC	PTHR10572:SF2	3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	IGI	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00018	EGF receptor signaling pathway	P00539	14-3-3	EMENI|EnsemblGenome=CADANIAG00005943|UniProtKB=Q5B4M9	1433_TRIHA 14-3-3 PROTEIN HOMOLOG (TH1433)	IGI	22017897	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00029	Huntington disease	P00805	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00021	FGF signaling pathway	P00628	JNK1-3	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00799	JNK-2	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02771	Pyrimidine Metabolism	P03126	Nucleoside Phosphorylase	METJA|EnsemblGenome=MJ_0667|UniProtKB=Q58081	AMP phosphorylase	ISS	8688087	PubMed	PTHR10515:SF0	THYMIDINE PHOSPHORYLASE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02747	Histidine biosynthesis	P02985	Histidinol dehydrogenase	LEPIN|EnsemblGenome=LA_2515|UniProtKB=Q8F393	Histidinol dehydrogenase	ISS			PTHR21256:SF2	HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN
P00034	Integrin signalling pathway	P00916	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00049	Parkinson disease	P01211	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	20216076	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00057	Wnt signaling pathway	P01434	sFRP	RAT|RGD=621074|UniProtKB=Q9R168	Secreted frizzled-related protein 1 (Fragment)	ISS	9096311	PubMed	PTHR11309:SF87	SECRETED FRIZZLED-RELATED PROTEIN 1
P00029	Huntington disease	P00805	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00046	Oxidative stress response	P01135	p38	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	TAS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00047	PDGF signaling pathway	P01158	PDGF receptor A	MOUSE|MGI=MGI=97530|UniProtKB=P26618	Platelet-derived growth factor receptor alpha	RCA			PTHR24416:SF52	PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	BOVIN|Ensembl=ENSBTAG00000047648|UniProtKB=G5E6N8	Uncharacterized protein	ISS	SYT2_MOUSE	SPACC	PTHR10024:SF223	SYNAPTOTAGMIN-2
P00036	Interleukin signaling pathway	P00970	Interleukin	MACMU|Ensembl=ENSMMUG00000015248|UniProtKB=F6VUJ0	Uncharacterized protein	IDA	11331040	PubMed	PTHR45200:SF1	INTERLEUKIN-18
P00021	FGF signaling pathway	P00639	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	95096035	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00052	TGF-beta signaling pathway	P01275	P38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	TAS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00034	Integrin signalling pathway	P00933	Crk	ORNAN|Ensembl=ENSOANG00000006947|UniProtKB=F7E9T7	Uncharacterized protein	ISS	8649368	PubMed	PTHR19969:SF9	CRK-LIKE PROTEIN
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MOUSE|MGI=MGI=1339713|UniProtKB=Q5SX39	Myosin-4	ISS	89264452	PubMed	PTHR13140:SF657	MYOSIN-4
P00034	Integrin signalling pathway	P00906	Rap1	DANRE|ZFIN=ZDB-GENE-030131-9662|UniProtKB=Q6TEN1	Ras-related protein Rap-1b	ISS	10476970	PubMed	PTHR24070:SF382	RAS-RELATED PROTEIN RAP-1B
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P02721	ATP synthesis	P02798	Cyt C	ANOGA|EnsemblGenome=AGAP009537|UniProtKB=Q7PSA9	AGAP009537-PA	ISS	6091761	PubMed	PTHR11961:SF12	CYTOCHROME C
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_127489|UniProtKB=C3XYC6	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00859	NFkappaB	HUMAN|HGNC=7795|UniProtKB=Q00653	Nuclear factor NF-kappa-B p100 subunit	ISS	9133421	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00054	Toll receptor signaling pathway	P01358	ERK1	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DANRE|ZFIN=ZDB-GENE-050417-267|UniProtKB=F1QUN8	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF263	ACTIN
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	11956331	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00049	Parkinson disease	P01221	Torsin A	MOUSE|MGI=MGI=1353596|UniProtKB=Q8R1J9	Torsin-2A	IDA	12421356	PubMed	PTHR10760:SF4	TORSIN-2A
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000003128|UniProtKB=H2Q2V4	Uncharacterized protein	ISS	2137198	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	DANRE|ZFIN=ZDB-GENE-990415-199|UniProtKB=A3QJX7	Uncharacterized protein	IDA	12093103	PubMed	PTHR24229:SF74	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00568	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=1306801|UniProtKB=F8VPK8	Protein Pcdh9	ISS	8120095	PubMed	PTHR43912:SF5	PROTOCADHERIN-9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IDA	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00021	FGF signaling pathway	P00644	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	IPI	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04398	p53 pathway feedback loops 2	P04657	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IDA	89186920	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04393	Ras Pathway	P04557	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IDA	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	IC	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00047	PDGF signaling pathway	P01142	p90RSK	ANOGA|EnsemblGenome=AGAP003040|UniProtKB=Q7QDB4	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF110	RIBOSOMAL PROTEIN S6 KINASE II, ISOFORM A
P00005	Angiogenesis	P00234	Grb2	DANRE|ZFIN=ZDB-GENE-040426-1975|UniProtKB=Q6PC73	Growth factor receptor-bound protein 2	ISS	8479536	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	RCA	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00036	Interleukin signaling pathway	P00974	Receptor subunit beta	MACMU|Ensembl=ENSMMUG00000005417|UniProtKB=F7GSZ4	Interleukin-2 receptor subunit beta	ISS	11238664	PubMed	PTHR23037:SF30	INTERLEUKIN-2 RECEPTOR SUBUNIT BETA
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	RAT|RGD=2743|UniProtKB=P31421	Metabotropic glutamate receptor 2	ISS	20012997	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P04393	Ras Pathway	P04570	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00185	JAK1	BOVIN|Ensembl=ENSBTAG00000003147|UniProtKB=F1N0D6	Tyrosine-protein kinase	ISS	11929133	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00015	Circadian clock system	G01501	cry	DANRE|ZFIN=ZDB-GENE-010426-4|UniProtKB=B0S7X5	Uncharacterized protein	ISS			PTHR11455:SF10	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01411	Ras	MONDO|Ensembl=ENSMODG00000025248|UniProtKB=F7F5X1	Uncharacterized protein	ISS	9869449	PubMed	PTHR24070:SF186	GTPASE KRAS
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00638	PLCgamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00019	Endothelin signaling pathway	P00577	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04586	ProTRH (Pro Thyrotropin-releasing Hormone)	DANRE|ZFIN=ZDB-GENE-030513-3|UniProtKB=B3DJU0	Thyroid stimulating hormone, beta subunit	ISS			PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00552	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	IDA	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00047	PDGF signaling pathway	P01173	STAT	MOUSE|MGI=MGI=103038|UniProtKB=P42227	Signal transducer and activator of transcription 3	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00011	Blood coagulation	P00458	GP IIIa	BOVIN|Ensembl=ENSBTAG00000009987|UniProtKB=F1MTN1	Integrin beta	ISS	124968	gi	PTHR10082:SF25	INTEGRIN BETA-3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00006	Apoptosis signaling pathway	P00274	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00182	p38MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	IC	91298951	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P05731	GABA-B receptor II signaling	P05752	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00060	Ubiquitin proteasome pathway	P01491	E2	YEAST|SGD=S000002466|UniProtKB=P15732	Ubiquitin-conjugating enzyme E2-16 kDa	ISS			PTHR24068:SF74	FI16911P1-RELATED
P00029	Huntington disease	P00790	beta-Tubulin	MOUSE|MGI=MGI=107813|UniProtKB=Q9ERD7	Tubulin beta-3 chain	TAS	9454836	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00034	Integrin signalling pathway	P00948	Rho	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	IGI	10556059	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	DANRE|ZFIN=ZDB-GENE-050417-441|UniProtKB=Q567Y8	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00970	Interleukin	PANTR|Ensembl=ENSPTRG00000012371|UniProtKB=H2QIK5	Interleukin 1, alpha	ISS	7561102	PubMed	PTHR45409:SF1	INTERLEUKIN-1 ALPHA
P00054	Toll receptor signaling pathway	P01352	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00542	EGFR	PANTR|Ensembl=ENSPTRG00000012883|UniProtKB=H2QJC5	Receptor protein-tyrosine kinase	ISS	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00036	Interleukin signaling pathway	P00981	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00021	FGF signaling pathway	P00628	JNK1-3	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04567	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	BOVIN|Ensembl=ENSBTAG00000005119|UniProtKB=A7MBA2	PSMD1 protein	ISS			PTHR10943:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00006	Apoptosis signaling pathway	P00321	HSP70	ANOGA|EnsemblGenome=AGAP004192|UniProtKB=Q7PQK5	AGAP004192-PA	ISS	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00053	T cell activation	P01324	rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05918	p38 MAPK pathway	P06031	p38alpha	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P02749	Leucine biosynthesis	P03001	3-Isopropylmalate dehydrogenase	SYNY3|EnsemblGenome=BAA18028|UniProtKB=P73960	3-isopropylmalate dehydrogenase	ISS			PTHR42979:SF2	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	IDA	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P06959	CCKR signaling map	P07151	p52 SHC1	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	RCA	8549807	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00057	Wnt signaling pathway	P01444	Wnt	MONDO|Ensembl=ENSMODG00000013810|UniProtKB=F6SXE3	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	IDA	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00223	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00012	Cadherin signaling pathway	P00470	F-actin	SCHMA|EnsemblGenome=Smp_046600|UniProtKB=G4VLW2	Putative actin-1	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00010	B cell activation	P00373	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IGI	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00010	B cell activation	P00402	Jnk	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-8225|UniProtKB=Q7SZZ5	Uncharacterized protein	ISS			PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	20264070	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00021	FGF signaling pathway	P00628	JNK1-3	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	MOUSE|MGI=MGI=1278315|UniProtKB=Q91VN0	Low-density lipoprotein receptor-related protein 5	ISS	11907044	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-010705-1|UniProtKB=Q90Z40	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=3233|UniProtKB=P33533	Delta-type opioid receptor	IDA	11259487	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01080	AChE	CAEBR|Gene=CBG14965|UniProtKB=A8XL40	Carboxylic ester hydrolase	ISS	87080761	PubMed	PTHR43918:SF6	CARBOXYLIC ESTER HYDROLASE
P00023	General transcription regulation	P00669	TFIIEalpha	DROME|FlyBase=FBgn0015828|UniProtKB=O96880	GH11150p	ISS			PTHR13097:SF7	NOVEL PROTEIN SIMILAR TO VERTEBRATE GENERAL TRANSCRIPTION FACTOR IIE POLYPEPTIDE 1 ALPHA 56KDA  GTF2E1
P00053	T cell activation	P01324	rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	15470041	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	PANTR|Gene=CHRM2|UniProtKB=Q9N2A7	Muscarinic acetylcholine receptor M2 (Fragment)	ISS	12181435	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000012036|UniProtKB=F7ALP1	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IDA	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00049	Parkinson disease	P01208	Hsp70	SYNY3|EnsemblGenome=BAA17123|UniProtKB=P73098	Chaperone protein dnaK3	ISS	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P00029	Huntington disease	P00776	c-Jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00059	p53 pathway	G04694	p110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05994	G-protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	ISS	10704417	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	CIOIN|Ensembl=ENSCING00000008616|UniProtKB=F6T2A6	Uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00021	FGF signaling pathway	P00634	MEKK1-5	MOUSE|MGI=MGI=1346875|UniProtKB=O08648	Mitogen-activated protein kinase kinase kinase 4	IGI	9079650	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00029	Huntington disease	P00807	Actin	XENTR|Xenbase=XB-GENE-491938|UniProtKB=Q6DIV8	Actin, alpha 1, skeletal muscle	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00034	Integrin signalling pathway	P00912	Arp2/3	RAT|RGD=1305848|UniProtKB=P85970	Actin-related protein 2/3 complex subunit 2	ISS	12473693	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00019	Endothelin signaling pathway	P00587	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00012	Cadherin signaling pathway	P00470	F-actin	CHICK|Ensembl=ENSGALG00000028749|UniProtKB=Q5ZMQ2	Actin, cytoplasmic 2	ISS	11889139	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00029	Huntington disease	P00805	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	1170702	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P01480	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00758	Phosducin	MACMU|Ensembl=ENSMMUG00000008986|UniProtKB=F7EQ61	Uncharacterized protein	ISS	10360181	PubMed	PTHR21148:SF17	PHOSDUCIN
P00010	B cell activation	P00398	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IDA	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00018	EGF receptor signaling pathway	P00547	PP2A	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P05731	GABA-B receptor II signaling	P05753	Ca channel	MOUSE|MGI=MGI=88296|UniProtKB=O55017	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	8386525	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00925	MEK	MOUSE|MGI=MGI=1346869|UniProtKB=P47809	Dual specificity mitogen-activated protein kinase kinase 4	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00005	Angiogenesis	P00219	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00627	ERK1-2	ARATH|TAIR=AT1G01560|UniProtKB=Q9LMM5	Mitogen-activated protein kinase 11	ISS			PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P00005	Angiogenesis	P00220	c-Jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DANRE|ZFIN=ZDB-GENE-041210-195|UniProtKB=F1R506	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00034	Integrin signalling pathway	P00951	Jnk	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	ORNAN|Ensembl=ENSOANG00000007391|UniProtKB=F6PQH1	Uncharacterized protein	ISS	94365697	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P00025	Hedgehog signaling pathway	P00699	Su(fu)	CANLF|Ensembl=ENSCAFG00000010221|UniProtKB=E2RAI7	Suppressor of fused homolog	ISS	12068298	PubMed	PTHR10928:SF2	SUPPRESSOR OF FUSED HOMOLOG
P00047	PDGF signaling pathway	P01143	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05731	GABA-B receptor II signaling	P05752	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05913	Enkephalin release	P05975	GPCR (s)	PANTR|Gene=OPRM1|UniProtKB=Q5IS39	Mu-type opioid receptor	ISS	12093103	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P05913	Enkephalin release	P05977	G-Protein (s)	DANRE|ZFIN=ZDB-GENE-040426-1712|UniProtKB=Q6PBY0	Guanine nucleotide binding protein (G protein), beta 5	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00034	Integrin signalling pathway	P00909	ASAP1	PANTR|Ensembl=ENSPTRG00000020587|UniProtKB=H2QWQ5	Uncharacterized protein	RCA			PTHR23180:SF192	ARF-GAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	XENTR|Xenbase=XB-GENE-6469705|UniProtKB=Q6P8G3	Actin, alpha sarcomeric/skeletal	ISS	14684598	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00029	Huntington disease	P00779	TBP	SULSO|EnsemblGenome=SSO0951|UniProtKB=P58178	TATA-box-binding protein	IPI	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00019	Endothelin signaling pathway	P00566	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	21071228	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00005	Angiogenesis	P00237	FRP	RAT|RGD=1311315|UniProtKB=B2GUW1	Frizzled-related protein	ISS	9118218	PubMed	PTHR11309:SF97	SECRETED FRIZZLED-RELATED PROTEIN 3
P00053	T cell activation	P01309	fos	RAT|RGD=2626|UniProtKB=P12841	Proto-oncogene c-Fos	TAS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04397	p53 pathway by glucose deprivation	G04706	TSC2	BOVIN|Ensembl=ENSBTAG00000020617|UniProtKB=E1BNT2	Uncharacterized protein	ISS	15249583	PubMed	PTHR10063:SF0	TUBERIN
P02746	Heme biosynthesis	P02983	Hydroxymethylbilane synthase	HUMAN|HGNC=4982|UniProtKB=P08397	Porphobilinogen deaminase	ISS			PTHR11557:SF0	PORPHOBILINOGEN DEAMINASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00030	Hypoxia response via HIF activation	P00814	P300	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00021	FGF signaling pathway	P00646	RasGAP	DROME|FlyBase=FBgn0004390|UniProtKB=P48423	GTPase-activating protein	ISS	92191280	PubMed	PTHR10194:SF126	GTPASE-ACTIVATING PROTEIN
P00011	Blood coagulation	P00443	Fibrin polymer cross-linked	RAT|RGD=2603|UniProtKB=P06399	Fibrinogen alpha chain	ISS	87134033	PubMed	PTHR19143:SF232	FIBRINOGEN ALPHA CHAIN
P00005	Angiogenesis	P00223	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04560	AP1	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	P17325	SPACC	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00057	Wnt signaling pathway	P01443	Phospholipase C	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IDA	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IC	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00549	EGF	HUMAN|HGNC=651|UniProtKB=P15514	Amphiregulin	IGI	4502199	gi	PTHR10740:SF12	AMPHIREGULIN
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00018	EGF receptor signaling pathway	G01511	SPRY	MACMU|Ensembl=ENSMMUG00000001662|UniProtKB=F7G6M6	Uncharacterized protein	ISS			PTHR12365:SF9	PROTEIN SPROUTY HOMOLOG 3
P00021	FGF signaling pathway	P00644	p38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IGI	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	MOUSE|MGI=MGI=1346037|UniProtKB=Q9WTL4	Insulin receptor-related protein	ISS	12644000	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	DICPU|Gene=DICPUDRAFT_93216|UniProtKB=F1A421	Guanine nucleotide-binding protein subunit beta	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	CANLF|Gene=PSEN1|UniProtKB=Q6RH31	Presenilin-1	ISS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00010	B cell activation	P00385	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ARATH|TAIR=AT2G42100|UniProtKB=Q8RYC2	Putative actin-5	IC	10974003	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00047	PDGF signaling pathway	P01142	p90RSK	MACMU|Ensembl=ENSMMUG00000007610|UniProtKB=F6SDH6	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF41	RIBOSOMAL PROTEIN S6 KINASE ALPHA-4
P04393	Ras Pathway	P04547	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	3035212	PubMed	PTHR24070:SF385	GTPASE HRAS
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05913	Enkephalin release	P05972	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	BOVIN|Ensembl=ENSBTAG00000008059|UniProtKB=P41984	Muscarinic acetylcholine receptor M3	TAS	12181435	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00254	GTPase	XENTR|Xenbase=XB-GENE-941426|UniProtKB=Q28HZ4	Novel Rho protein	ISS	12024019	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00018	EGF receptor signaling pathway	P00559	MEK1-2	SCHPO|PomBase=SPAC1D4.13|UniProtKB=P10506	Protein kinase byr1	ISS			PTHR24361:SF395	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	DANRE|ZFIN=ZDB-GENE-980526-137|UniProtKB=Q98880	Acetylcholine receptor subunit alpha	ISS	85270494	PubMed	PTHR18945:SF74	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00577	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05915	Opioid proenkephalin pathway	P05994	G-protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P06959	CCKR signaling map	P07020	p110	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	RCA	11208554	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MOUSE|MGI=MGI=95819|UniProtKB=P35438	Glutamate receptor ionotropic, NMDA 1	IC	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00029	Huntington disease	P00775	Rac	ARATH|TAIR=AT2G44690|UniProtKB=Q9XGU0	Rac-like GTP-binding protein ARAC9	TAS			PTHR24072:SF160	RAC-LIKE GTP-BINDING PROTEIN ARAC9
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	HUMAN|HGNC=4388|UniProtKB=P38405	Guanine nucleotide-binding protein G(olf) subunit alpha	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P04393	Ras Pathway	P04559	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	10540223	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00036	Interleukin signaling pathway	P00981	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MACMU|Ensembl=ENSMMUG00000013995|UniProtKB=F6RRN8	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF155	REGULATOR OF G-PROTEIN SIGNALING 18
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00056	VEGF signaling pathway	P01408	Akt/PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01181	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00036	Interleukin signaling pathway	P00996	STAT	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	12191995	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	TAS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00068	amine translocator	MACMU|Ensembl=ENSMMUG00000010938|UniProtKB=F7GJ70	Transporter	ISS	12719981	PubMed	PTHR11616:SF109	SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER B 0 AT3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	TAKRU|Ensembl=ENSTRUG00000008175|UniProtKB=H2T716	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF26	REGULATOR OF G-PROTEIN SIGNALING 7
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00006	Apoptosis signaling pathway	P00272	ASK1	MACMU|Ensembl=ENSMMUG00000016376|UniProtKB=F7G2W1	Uncharacterized protein	ISS	12697749	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00054	Toll receptor signaling pathway	P01377	MyD88	XENTR|Xenbase=XB-GENE-486650|UniProtKB=Q28DJ2	Myeloid differentiation primary response protein MyD88	ISS			PTHR15079:SF3	MYELOID DIFFERENTIATION PRIMARY RESPONSE PROTEIN MYD88
P00048	PI3 kinase pathway	P01185	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00009	Axon guidance mediated by netrin	P00357	Netrin	PANTR|Ensembl=ENSPTRG00000021493|UniProtKB=H2QY29	Uncharacterized protein	ISS			PTHR10574:SF27	NETRIN-G2
P04393	Ras Pathway	P04548	ATF2	MONDO|Ensembl=ENSMODG00000009514|UniProtKB=F7EVK3	Uncharacterized protein	ISS	15218628	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00049	Parkinson disease	P01227	20S proteasome	DANRE|ZFIN=ZDB-GENE-010502-2|UniProtKB=Q6GQM3	Proteasome subunit alpha type	TAS	12859888	PubMed	PTHR11599:SF11	PROTEASOME SUBUNIT ALPHA TYPE-6
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000010393|UniProtKB=F7D992	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	HUMAN|HGNC=20772|UniProtKB=Q13509	Tubulin beta-3 chain	ISS	9454836	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00018	EGF receptor signaling pathway	P00547	PP2A	PHYPA|Gene=PHYPADRAFT_109960|UniProtKB=A9SI18	Serine/threonine-protein phosphatase	ISS			PTHR11668:SF318	SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-4 CATALYTIC SUBUNIT
P00056	VEGF signaling pathway	P01408	Akt/PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DANRE|ZFIN=ZDB-GENE-030131-172|UniProtKB=Q6IQR3	Actin, alpha, cardiac muscle 1a	IC	14684598	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=11438|UniProtKB=Q13277	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00036	Interleukin signaling pathway	P00965	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01153	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00005	Angiogenesis	P00219	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	MOUSE|MGI=MGI=95818|UniProtKB=Q61626	Glutamate receptor ionotropic, kainate 5	ISS	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANAL|CGD=CAL0003231|UniProtKB=Q5ANK2	Protein kinase C	TAS	125549	gi	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MONDO|Ensembl=ENSMODG00000001775|UniProtKB=F6WJB1	Uncharacterized protein	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00036	Interleukin signaling pathway	P00973	PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04396	Vitamin D metabolism and pathway	P04604	FdxR	ANOGA|EnsemblGenome=AGAP005419|UniProtKB=Q7Q7A2	NADPH:adrenodoxin oxidoreductase, mitochondrial	ISS			PTHR11938:SF91	NADPH:ADRENODOXIN OXIDOREDUCTASE, MITOCHONDRIAL
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	PANTR|Ensembl=ENSPTRG00000017401|UniProtKB=H2R587	Casein kinase 1, alpha 1	ISS	11437445	PubMed	PTHR11909:SF84	CASEIN KINASE I ISOFORM ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BOVIN|Gene=ACTB|UniProtKB=P60712	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00021	FGF signaling pathway	P00627	ERK1-2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	ARATH|TAIR=AT3G12980|UniProtKB=Q9LE42	Histone acetyltransferase HAC5	TAS	8413673	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00049	Parkinson disease	P01236	Casein kinase II	ANOGA|EnsemblGenome=AGAP005569|UniProtKB=Q7Q707	AGAP005569-PA	ISS	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00056	VEGF signaling pathway	P01424	Sck	HUMAN|HGNC=29869|UniProtKB=P98077	SHC-transforming protein 2	IDA	600560	OMIM	PTHR10337:SF5	SHC-TRANSFORMING PROTEIN 2
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02781	Threonine biosynthesis	P03192	Aspartate semialdehyde dehydrogenase	GLOVI|Gene=BAC88958|UniProtKB=Q7NLV2	Aspartate-semialdehyde dehydrogenase	ISS			PTHR10174:SF2	ASPARTATE-SEMIALDEHYDE DEHYDROGENASE
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	DANRE|ZFIN=ZDB-GENE-991119-4|UniProtKB=Q9W6T7	Presenilin-1	IDA	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	PANTR|Ensembl=ENSPTRG00000012128|UniProtKB=H2QI87	Uncharacterized protein	ISS	11266476	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00048	PI3 kinase pathway	P01206	14-3-3	MONDO|Ensembl=ENSMODG00000006158|UniProtKB=F7BS95	Uncharacterized protein	ISS	12615066	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	RAT|RGD=621705|UniProtKB=Q8VHN2	Glutamate receptor ionotropic, NMDA 3B	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P02741	Flavin biosynthesis	P02936	FAD synthetase	BACSU|EnsemblGenome=BSU16670|UniProtKB=P54575	Riboflavin biosynthesis protein RibC	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PHANO|Gene=SNOG_06790|UniProtKB=P41799	Tubulin beta chain	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P05913	Enkephalin release	P05973	GPCR (i)	CANLF|Ensembl=ENSCAFG00000011689|UniProtKB=E2QZY2	Uncharacterized protein	ISS	12093103	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00029	Huntington disease	P00790	beta-Tubulin	NEUCR|EnsemblGenome=EFNCRG00000003612|UniProtKB=P05220	Tubulin beta chain	TAS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	IXOSC|EnsemblGenome=ISCW024111|UniProtKB=B7PBG2	Actin, putative (Fragment)	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02743	Formyltetrahydroformate biosynthesis	P02954	Thymidylate synthase	BACSU|EnsemblGenome=BSU17680|UniProtKB=P0CI79	Thymidylate synthase 1	ISS			PTHR11548:SF1	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00628	JNK1-3	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00029	Huntington disease	P00786	ARF	DICDI|dictyBase=DDB_G0289173|UniProtKB=O00909	ADP-ribosylation factor 1	IPI	12932731	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	TAKRU|Ensembl=ENSTRUG00000016241|UniProtKB=H2UX35	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF305	PROTEIN KINASE C
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00029	Huntington disease	P00780	Microtubule	BRAFL|Gene=BRAFLDRAFT_120208|UniProtKB=C3YMF1	Putative uncharacterized protein	ISS			PTHR11588:SF89	TUBULIN BETA-4 CHAIN
P00046	Oxidative stress response	P01129	JNK1/2	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00020	FAS signaling pathway	P00615	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04397	p53 pathway by glucose deprivation	P04641	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	HUMAN|HGNC=4574|UniProtKB=P48058	Glutamate receptor 4	ISS	12497607	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00011	Blood coagulation	P00433	uPAR	HUMAN|HGNC=9053|UniProtKB=Q03405	Urokinase plasminogen activator surface receptor	ISS	11875699	gi	PTHR10624:SF6	UROKINASE PLASMINOGEN ACTIVATOR SURFACE RECEPTOR
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	CAEBR|Gene=CBG19844|UniProtKB=E3CU74	S-adenosylmethionine synthase	ISS			PTHR11964:SF1	S-ADENOSYLMETHIONINE SYNTHASE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	CANLF|Ensembl=ENSCAFG00000015856|UniProtKB=J9P3S5	Nucleoside diphosphate kinase	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P04393	Ras Pathway	P04578	Rho	DANRE|ZFIN=ZDB-GENE-040426-2150|UniProtKB=Q6NUX8	Rho-related GTP-binding protein RhoA-A	ISS	11973360	PubMed	PTHR24072:SF260	RHO-RELATED GTP-BINDING PROTEIN RHOA-A-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	ANOGA|EnsemblGenome=AGAP005913|UniProtKB=Q7Q6D2	AGAP005913-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	TAS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00005	Angiogenesis	P00193	SOS-1	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS			PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00053	T cell activation	P01311	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	DANRE|ZFIN=ZDB-GENE-040718-134|UniProtKB=Q6DH55	Guanine nucleotide binding protein (G protein), beta polypeptide 3, like	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00049	Parkinson disease	P01242	Casein kinase I	MACMU|Ensembl=ENSMMUG00000006620|UniProtKB=F7H481	Uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF157	CASEIN KINASE I ISOFORM GAMMA-2
P00047	PDGF signaling pathway	P01142	p90RSK	HUMAN|HGNC=10433|UniProtKB=O75676	Ribosomal protein S6 kinase alpha-4	ISS	9792677	PubMed	PTHR24351:SF41	RIBOSOMAL PROTEIN S6 KINASE ALPHA-4
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	CRYNJ|Gene=CNJ01940|UniProtKB=Q07801	Dihydrofolate reductase	ISS			PTHR22778:SF16	DIHYDROFOLATE REDUCTASE
P04393	Ras Pathway	P04556	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	IDA	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DANRE|ZFIN=ZDB-GENE-030131-6503|UniProtKB=Q7ZUC5	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF297	PROTEIN KINASE C DELTA TYPE
P00047	PDGF signaling pathway	P01153	GSK3	CANLF|Ensembl=ENSCAFG00000004882|UniProtKB=F1PAE3	Uncharacterized protein	ISS	14698990	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00029	Huntington disease	P00790	beta-Tubulin	MONDO|Ensembl=ENSMODG00000023805|UniProtKB=F7F082	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00005	Angiogenesis	P00193	SOS-1	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IDA	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00019	Endothelin signaling pathway	P00586	Gq	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	PANTR|Ensembl=ENSPTRG00000008153|UniProtKB=H2QB68	Chemokine (C-X3-C motif) ligand 1	ISS	11960641	PubMed	PTHR12015:SF92	FRACTALKINE
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00021	FGF signaling pathway	P00634	MEKK1-5	BOVIN|Ensembl=ENSBTAG00000008151|UniProtKB=F1MH06	Uncharacterized protein	ISS	8649450	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00005	Angiogenesis	P00223	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00050	Plasminogen activating cascade	P01253	Fibrin	PANTR|Ensembl=ENSPTRG00000016536|UniProtKB=H2RDH7	Uncharacterized protein	ISS	223170	gi	PTHR19143:SF338	FIBRINOGEN GAMMA CHAIN
P00025	Hedgehog signaling pathway	P00692	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00017	DNA replication	P00529	RFC	MOUSE|MGI=MGI=1916513|UniProtKB=Q8R323	Replication factor C subunit 3	RCA			PTHR11669:SF1	REPLICATION FACTOR C SUBUNIT 3
P00018	EGF receptor signaling pathway	P00561	STAT	MONDO|Ensembl=ENSMODG00000011767|UniProtKB=F7CW94	Signal transducer and activator of transcription	ISS	12496413	PubMed	PTHR11801:SF19	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 4
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P06587	Nicotine pharmacodynamics pathway	P06590	GNG	MACMU|Ensembl=ENSMMUG00000010392|UniProtKB=F7ASR8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00059	p53 pathway	P04633	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CHICK|Gene=ACTG2|UniProtKB=P63270	Actin, gamma-enteric smooth muscle	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	PANTR|Ensembl=ENSPTRG00000021402|UniProtKB=H2R6A3	Adenylate kinase isoenzyme 1	ISS			PTHR23359:SF59	ADENYLATE KINASE ISOENZYME 1
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P02771	Pyrimidine Metabolism	P03130	Cytidine Deaminase	HUMAN|HGNC=1712|UniProtKB=P32320	Cytidine deaminase	IEP	12844405	PubMed	PTHR11644:SF2	CYTIDINE DEAMINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PHYIT|EnsemblGenome=PITG_15117|UniProtKB=D0NRP9	Actin-like protein	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00053	T cell activation	P01300	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04398	p53 pathway feedback loops 2	G04712	P21	MOUSE|MGI=MGI=104556|UniProtKB=P39689	Cyclin-dependent kinase inhibitor 1	IGI	7774811	PubMed	PTHR10265:SF16	CYCLIN-DEPENDENT KINASE INHIBITOR 1
P00010	B cell activation	P00398	IP3R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P02721	ATP synthesis	P02796	F1 gamma	MACMU|Ensembl=ENSMMUG00000009207|UniProtKB=F7HJS5	ATP synthase subunit gamma	ISS	9736690	PubMed	PTHR11693:SF22	ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	ARATH|TAIR=AT1G13890|UniProtKB=Q9LMG8	Putative SNAP25 homologous protein SNAP30	ISS	14744428	PubMed	PTHR19305:SF7	SNAP25 HOMOLOGOUS PROTEIN SNAP30-RELATED
P00046	Oxidative stress response	P01134	cPLA2	BOVIN|Ensembl=ENSBTAG00000013298|UniProtKB=A4IFJ5	Cytosolic phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04397	p53 pathway by glucose deprivation	P04639	AMPK	BOVIN|Ensembl=ENSBTAG00000005940|UniProtKB=Q5BIS9	5'-AMP-activated protein kinase subunit beta-1	ISS			PTHR10343:SF16	5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	SCLS1|EnsemblGenome=SS1G_03482|UniProtKB=A7EDU2	Guanine nucleotide-binding protein beta subunit	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P02774	Salvage pyrimidine deoxyribonucleotides	P03145	Uracil phosphorylase	BACSU|EnsemblGenome=BSU39400|UniProtKB=P39142	Pyrimidine-nucleoside phosphorylase	ISS	10567266	PubMed	PTHR10515:SF0	THYMIDINE PHOSPHORYLASE
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00018	EGF receptor signaling pathway	P00539	14-3-3	RAT|RGD=62002|UniProtKB=P61983	14-3-3 protein gamma	ISS	10407019	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00024	Glycolysis	P00680	Phosphoglyceromutase	SCHPO|PomBase=SPAC26F1.06|UniProtKB=P36623	Phosphoglycerate mutase	ISS	21848401	PubMed	PTHR11931:SF0	AT20876P-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01395	TFIIE	RAT|RGD=1310134|UniProtKB=D3ZCP9	Transcription initiation factor IIE subunit beta	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P00057	Wnt signaling pathway	P01443	Phospholipase C	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IDA	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	TAS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P02738	De novo purine biosynthesis	P02909	GDP reductase	CAEEL|WormBase=WBGene00004392|UniProtKB=P42170	Ribonucleoside-diphosphate reductase small chain	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00786	ARF	LEIMA|EnsemblGenome=LmjF.17.0070|UniProtKB=Q4QEJ1	ADP-ribosylation factor-like protein 1	ISS	12932731	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P04395	Vasopressin synthesis	P04589	Signal Peptidase	ARATH|TAIR=AT2G39960|UniProtKB=P58684	Probable signal peptidase complex subunit 2	IC	7788527	PubMed	PTHR13085:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 2
P02738	De novo purine biosynthesis	P02902	ADP reductase	YEAST|SGD=S000000872|UniProtKB=P21524	Ribonucleoside-diphosphate reductase large chain 1	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00029	Huntington disease	P00774	Dynein complex	PANTR|Ensembl=ENSPTRG00000023476|UniProtKB=H2R155	Uncharacterized protein	ISS	9454836	PubMed	PTHR12442:SF22	CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN 2
P05916	Opioid prodynorphin pathway	P06002	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00010	B cell activation	P00379	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00255	Notch	CANLF|Ensembl=ENSCAFG00000010476|UniProtKB=F1PS94	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Ensembl=ENSBTAG00000007642|UniProtKB=Q0VC81	Adenosine receptor A3	ISS	11781138	PubMed	PTHR24246:SF2	ADENOSINE RECEPTOR A3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000007576|UniProtKB=H2QA92	Uncharacterized protein	ISS	12562507	PubMed	PTHR24229:SF20	SOMATOSTATIN RECEPTOR TYPE 5
P02762	Pentose phosphate pathway	P03081	Transaldolase	PANTR|Ensembl=ENSPTRG00000003132|UniProtKB=H2Q2V7	Transaldolase	ISS	8300619	PubMed	PTHR10683:SF18	TRANSALDOLASE
P04393	Ras Pathway	P04572	JNK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=2652894|UniProtKB=Q80Y86	Mitogen-activated protein kinase 15	ISS	10851062	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00877	MLCK	PANTR|Ensembl=ENSPTRG00000015307|UniProtKB=H2R459	Uncharacterized protein	ISS	11157482	PubMed	PTHR45480:SF1	MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE
P00049	Parkinson disease	P01211	ERK	MACMU|Ensembl=ENSMMUG00000001187|UniProtKB=F6R8N9	Mitogen-activated protein kinase	ISS	11875070	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00398	IP3R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	IGI	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00005	Angiogenesis	P00206	Wnt	MACMU|Ensembl=ENSMMUG00000015709|UniProtKB=F6SLX4	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00053	T cell activation	P01300	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347742|UniProtKB=E9FZ00	Cytoplasmatic actin	ISS	11889126	PubMed	PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00005	Angiogenesis	P00233	CSL	MACMU|Ensembl=ENSMMUG00000015828|UniProtKB=F7CE90	Recombining binding protein suppressor of hairless isoform 4	ISS	8406481	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00006	Apoptosis signaling pathway	P00321	HSP70	TAKRU|Ensembl=ENSTRUG00000003346|UniProtKB=H2S609	Uncharacterized protein	ISS	10934466	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	MOUSE|MGI=MGI=99474|UniProtKB=Q91YI4	Beta-arrestin-2	ISS	12464600	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00054	Toll receptor signaling pathway	P01356	ERK2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05913	Enkephalin release	P05977	G-Protein (s)	DROME|FlyBase=FBgn0001123|UniProtKB=P20354	G protein alpha s subunit	IC	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00021	FGF signaling pathway	P00633	Ras	DICDI|dictyBase=DDB_G0281385|UniProtKB=P32253	Ras-like protein rasC	IDA	94119591	PubMed	PTHR24070:SF251	RAS-LIKE PROTEIN RASC
P00053	T cell activation	P01333	cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P05917	Opioid proopiomelanocortin pathway	P06009	K+ channel	MOUSE|MGI=MGI=1100509|UniProtKB=O35111	Potassium channel subfamily K member 3	ISS	15282272	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00036	Interleukin signaling pathway	P00990	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00006	Apoptosis signaling pathway	P00269	MAPK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CAEEL|WormBase=WBGene00000067|UniProtKB=O45815	ACTin	ISS	10974003	PubMed	PTHR11937:SF352	ACTIN
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00018	EGF receptor signaling pathway	P00547	PP2A	ANOGA|EnsemblGenome=AGAP010172|UniProtKB=Q7PD38	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00059	p53 pathway	G01575	GADD45	MOUSE|MGI=MGI=107799|UniProtKB=P48316	Growth arrest and DNA damage-inducible protein GADD45 alpha	IGI	10097101	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	MACMU|Ensembl=ENSMMUG00000009054|UniProtKB=F7F735	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00049	Parkinson disease	P01219	SAPK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	NAS	7600581	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00059	p53 pathway	P04611	P300	BOVIN|Ensembl=ENSBTAG00000016198|UniProtKB=E1B8D6	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P02761	Pantothenate biosynthesis	P03067	3-methyl-2-oxobutanoate hydroxymethyltransferase	DEIRA|EnsemblGenome=DR_2615|UniProtKB=Q9RR81	3-methyl-2-oxobutanoate hydroxymethyltransferase	ISS			PTHR20881:SF0	3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE
P00054	Toll receptor signaling pathway	P01356	ERK2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00211	GSK3beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_127490|UniProtKB=C3XYC5	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00060	Ubiquitin proteasome pathway	P01490	E3	BOVIN|Ensembl=ENSBTAG00000019853|UniProtKB=F1N3W8	Uncharacterized protein	ISS	11252892	PubMed	PTHR11254:SF300	E3 UBIQUITIN-PROTEIN LIGASE SMURF2
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	BACSU|EnsemblGenome=BSU02470|UniProtKB=P42236	Probable aldehyde dehydrogenase YcbD	IC			PTHR43521:SF2	DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 12A1, MITOCHONDRIAL
P00053	T cell activation	P01316	MHC-antigen	RAT|RGD=1595867|UniProtKB=P20037	Rano class II histocompatibility antigen, B alpha chain	IPI	73139	PubMed	PTHR19944:SF59	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DQ ALPHA 1 CHAIN
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CAEBR|Gene=CBG10905|UniProtKB=A8XC86	Protein CBR-GLR-6	ISS	12941441	PubMed	PTHR18966:SF295	GLUTAMATE RECEPTOR FAMILY  AMPA
P00021	FGF signaling pathway	P00627	ERK1-2	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00627	ERK1-2	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	ISS	6319455	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=7601|UniProtKB=Q8NEV4	Myosin-IIIa	IC			PTHR13140:SF387	MYOSIN-IIIA
P04393	Ras Pathway	P04541	p90RSK	BOVIN|Ensembl=ENSBTAG00000021741|UniProtKB=F1MNR5	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00018	EGF receptor signaling pathway	P00557	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	HUMAN|HGNC=5293|UniProtKB=P28223	5-hydroxytryptamine receptor 2A	ISS	12441358	PubMed	PTHR24247:SF30	5-HYDROXYTRYPTAMINE RECEPTOR 2A
P00049	Parkinson disease	P01242	Casein kinase I	ARATH|TAIR=AT5G44100|UniProtKB=Q9FFH8	At5g44100	IDA	11437445	PubMed	PTHR11909:SF114	ADK1-RELATED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IDA	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00053	T cell activation	P01319	PAK	RAT|RGD=3250|UniProtKB=P35465	Serine/threonine-protein kinase PAK 1	ISS	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00036	Interleukin signaling pathway	P00965	ERK	RAT|RGD=621505|UniProtKB=P0C865	Mitogen-activated protein kinase 7	ISS	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00005	Angiogenesis	P00211	GSK3beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00057	Wnt signaling pathway	P01465	Ggamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	BOVIN|Ensembl=ENSBTAG00000002295|UniProtKB=F1N177	Uncharacterized protein	ISS	10207617	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04395	Vasopressin synthesis	P04597	Signal Peptide	MOUSE|MGI=MGI=97453|UniProtKB=P35454	Oxytocin-neurophysin 1	ISS	192340	OMIM	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00057	Wnt signaling pathway	P01458	Protein Kinase C	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	IDA	2837282	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00053	T cell activation	P01300	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00019	Endothelin signaling pathway	P00591	PLCbeta	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IGI	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04393	Ras Pathway	P04565	MKK4/7	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00053	T cell activation	P01307	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00004	Alzheimer disease-presenilin pathway	P00117	E-cadherin C-terminal fragment	PANTR|Ensembl=ENSPTRG00000008270|UniProtKB=H2QBE5	Uncharacterized protein	ISS	11953314	PubMed	PTHR24027:SF319	CADHERIN-1
P00057	Wnt signaling pathway	P01444	Wnt	DANRE|ZFIN=ZDB-GENE-990415-278|UniProtKB=P43446	Protein Wnt-10a	IDA	8717036	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	HUMAN|HGNC=1401|UniProtKB=Q02641	Voltage-dependent L-type calcium channel subunit beta-1	IC	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00036	Interleukin signaling pathway	P00970	Interleukin	HUMAN|HGNC=5966|UniProtKB=P20809	Interleukin-11	ISS	2145578	PubMed	PTHR16922:SF0	INTERLEUKIN-11
P00046	Oxidative stress response	P01129	JNK1/2	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05913	Enkephalin release	P05974	G-Protein (i)	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	IC	8170357	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	TAKRU|Ensembl=ENSTRUG00000011169|UniProtKB=H2TU36	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00023	General transcription regulation	P00658	TBP-associated factors	MACMU|Ensembl=ENSMMUG00000012875|UniProtKB=F6SFX7	Transcription initiation factor TFIID subunit 9-like protein	ISS			PTHR12595:SF3	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 9B
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02762	Pentose phosphate pathway	P03082	Transketolase	PANTR|Gene=TKT|UniProtKB=Q5R1W6	Transketolase	RCA			PTHR43195:SF3	TRANSKETOLASE
P00059	p53 pathway	P01480	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00037	Ionotropic glutamate receptor pathway	P01026	KA	BOVIN|Ensembl=ENSBTAG00000034854|UniProtKB=F1N246	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05913	Enkephalin release	P05974	G-Protein (i)	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=17792|UniProtKB=Q96AJ9	Vesicle transport through interaction with t-SNAREs homolog 1A	ISS	10908612	PubMed	PTHR21230:SF39	VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A
P00052	TGF-beta signaling pathway	P01284	JNK	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12960248	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00025	Hedgehog signaling pathway	P00691	CBP	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00051	TCA cycle	P01268	Aconitase	DROME|FlyBase=FBgn0037862|UniProtKB=Q8T4D6	Aconitate hydratase, mitochondrial	RCA			PTHR43160:SF3	ACONITATE HYDRATASE, MITOCHONDRIAL
P04393	Ras Pathway	P04570	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DICDI|dictyBase=DDB_G0289487|UniProtKB=P07829	Actin-3	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00021	FGF signaling pathway	P00634	MEKK1-5	MONDO|Ensembl=ENSMODG00000009983|UniProtKB=F6USY2	Uncharacterized protein	ISS	9006902	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=106624|UniProtKB=Q9QY06	Unconventional myosin-IXb	IC			PTHR13140:SF306	UNCONVENTIONAL MYOSIN-IXB
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P01485	p53	MACMU|Ensembl=ENSMMUG00000016466|UniProtKB=F7GBH1	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=30035|UniProtKB=Q8WYR1	Phosphoinositide 3-kinase regulatory subunit 5	ISS	12507995	PubMed	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00047	PDGF signaling pathway	P01173	STAT	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	14755057	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00057	Wnt signaling pathway	P01432	Beta-Catenin	MONDO|Ensembl=ENSMODG00000011192|UniProtKB=F6SRK5	Uncharacterized protein	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00018	EGF receptor signaling pathway	P00551	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	9332390	PubMed	PTHR10202:SF13	PRESENILIN-2
P00047	PDGF signaling pathway	P01150	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00006	Apoptosis signaling pathway	P00260	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=71083|UniProtKB=P30940	5-hydroxytryptamine receptor 1F	IDA	12181435	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00047	PDGF signaling pathway	P01150	PKC	CANAL|CGD=CAL0003231|UniProtKB=Q5ANK2	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	IC	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00047	PDGF signaling pathway	P01154	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	ANOGA|EnsemblGenome=AGAP009447|UniProtKB=Q7PTN3	S-adenosylmethionine synthase	ISS			PTHR11964:SF1	S-ADENOSYLMETHIONINE SYNTHASE
P00057	Wnt signaling pathway	P01438	PP2A	ORNAN|Ensembl=ENSOANG00000009097|UniProtKB=F7G755	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	RCA	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00019	Endothelin signaling pathway	P00589	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00046	Oxidative stress response	P01135	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04393	Ras Pathway	P04542	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00049	Parkinson disease	P01232	CASK	RAT|RGD=62004|UniProtKB=Q62915	Peripheral plasma membrane protein CASK	IPI	11430913	PubMed	PTHR23122:SF40	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	CANLF|Ensembl=ENSCAFG00000001911|UniProtKB=E2RC62	10-formyltetrahydrofolate dehydrogenase	ISS			PTHR11699:SF131	MITOCHONDRIAL 10-FORMYLTETRAHYDROFOLATE DEHYDROGENASE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	XENTR|Xenbase=XB-GENE-956713|UniProtKB=Q5XGD8	Guanine nucleotide binding protein, beta 3	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	RAT|RGD=2732|UniProtKB=P22756	Glutamate receptor ionotropic, kainate 1	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P05912	Dopamine receptor mediated signaling pathway	P05961	DOPA decarb.	MOUSE|MGI=MGI=94876|UniProtKB=O88533	Aromatic-L-amino-acid decarboxylase	ISS	7567987	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00049	Parkinson disease	P01219	SAPK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	NAS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00029	Huntington disease	P00797	p53	ORNAN|Ensembl=ENSOANG00000005079|UniProtKB=F6PFV4	Uncharacterized protein (Fragment)	ISS			PTHR12195:SF1	CYTOPLASMIC FMR1-INTERACTING PROTEIN 2
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05760	AC	MOUSE|MGI=MGI=99674|UniProtKB=Q91WF3	Adenylate cyclase type 4	RCA	2491850	PubMed	PTHR11920:SF286	ADENYLATE CYCLASE TYPE 4
P00001	Adrenaline and noradrenaline biosynthesis	P00071	VAT1	MACMU|Ensembl=ENSMMUG00000019999|UniProtKB=F7FNE2	Uncharacterized protein	ISS	92370677	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IDA	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	BOVIN|Ensembl=ENSBTAG00000009269|UniProtKB=F1MCM2	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ANOGA|EnsemblGenome=AGAP005911|UniProtKB=Q7Q6D4	AGAP005911-PA	IC	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00049	Parkinson disease	P01222	Ubc6	ANOGA|EnsemblGenome=AGAP005954|UniProtKB=Q7Q6A2	AGAP005954-PA	TAS	12859888	PubMed	PTHR43972:SF1	UBIQUITIN-CONJUGATING ENZYME E2 J2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00009	Axon guidance mediated by netrin	P00359	NFAT	HUMAN|HGNC=7778|UniProtKB=Q14934	Nuclear factor of activated T-cells, cytoplasmic 4	IDA	12787506	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	ISS	188830	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00545	JNK1-3	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01142	p90RSK	CANLF|Ensembl=ENSCAFG00000017679|UniProtKB=E2RMD8	Ribosomal protein S6 kinase	ISS	11861821	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	NAS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	ORNAN|Ensembl=ENSOANG00000004982|UniProtKB=F7DIA9	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF34	FRIZZLED-2
P00036	Interleukin signaling pathway	P00990	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02774	Salvage pyrimidine deoxyribonucleotides	P03147	Thymidine kinase	PYRAE|EnsemblGenome=PAE2453|UniProtKB=Q8ZV53	Thymidine kinase	ISS			PTHR11441:SF0	THYMIDINE KINASE, CYTOSOLIC
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00019	Endothelin signaling pathway	P00567	PKG	MACMU|Ensembl=ENSMMUG00000019859|UniProtKB=F7GTI6	cGMP-dependent protein kinase	ISS	22181250	PubMed	PTHR24353:SF24	SUBFAMILY NOT NAMED
P00009	Axon guidance mediated by netrin	P00366	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12874273	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=107451|UniProtKB=Q8K2J0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3	ISS	15611108	PubMed	PTHR10336:SF33	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000008719|UniProtKB=F1MZX0	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04398	p53 pathway feedback loops 2	P04665	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00056	VEGF signaling pathway	P01410	Caspase9	MOUSE|MGI=MGI=1277950|UniProtKB=Q8C3Q9	Caspase-9	ISS	9390557	PubMed	PTHR10454:SF157	CASPASE-9
P00029	Huntington disease	P00775	Rac	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS	12606638	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	MOUSE|MGI=MGI=96647|UniProtKB=P09450	Transcription factor jun-B	ISS	10664585	PubMed	PTHR11462:SF37	TRANSCRIPTION FACTOR JUN-B
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	CANLF|Ensembl=ENSCAFG00000005766|UniProtKB=F1PNW4	Uncharacterized protein	ISS	1840599	PubMed	PTHR10024:SF239	SYNAPTOTAGMIN-1
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00373	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00048	PI3 kinase pathway	P01188	Gbetagamma	DAPPU|EnsemblGenome=DAPPUDRAFT_206575|UniProtKB=E9FUX0	Guanine nucleotide binding protein, beta subunit	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P05915	Opioid proenkephalin pathway	P05994	G-protein	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MACMU|Ensembl=ENSMMUG00000019351|UniProtKB=Q2YEG0	C-X-C chemokine receptor type 1	ISS	9110929	PubMed	PTHR10489:SF916	C-X-C CHEMOKINE RECEPTOR TYPE 1
P00034	Integrin signalling pathway	P00924	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06807	gnai	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00036	Interleukin signaling pathway	P00965	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ORYSJ|EnsemblGenome=OS03G0836000|UniProtKB=Q10AZ4	Actin-3	IDA	11889126	PubMed	PTHR11937:SF254	ACTIN-1-RELATED
P00005	Angiogenesis	P00205	GAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	14707121	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	PANTR|Ensembl=ENSPTRG00000019277|UniProtKB=H2QUQ1	Uncharacterized protein	ISS	1321498	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P02746	Heme biosynthesis	P02975	Uroporphyrinogen decarboxylase	DROME|FlyBase=FBgn0033428|UniProtKB=Q9V595	Uroporphyrinogen decarboxylase	ISS			PTHR21091:SF2	UROPORPHYRINOGEN DECARBOXYLASE
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04393	Ras Pathway	P04578	Rho	HUMAN|HGNC=667|UniProtKB=P61586	Transforming protein RhoA	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00036	Interleukin signaling pathway	P00997	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	8264585	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	ANOGA|EnsemblGenome=AGAP010457|UniProtKB=Q7QDW7	AGAP010457-PA	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00005	Angiogenesis	P00256	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	IC	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00059	p53 pathway	P01485	p53	MACMU|Ensembl=ENSMMUG00000008639|UniProtKB=P56424	Cellular tumor antigen p53	TAS	11313951	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00057	Wnt signaling pathway	P01444	Wnt	RAT|RGD=1311441|UniProtKB=A0A0G2K3B7	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	HUMAN|HGNC=6091|UniProtKB=P06213	Insulin receptor	ISS	6754360	gi	PTHR24416:SF402	INSULIN RECEPTOR
P02783	Tryptophan biosynthesis	P03206	Anthranilate synthase	METAC|EnsemblGenome=MA_2987|UniProtKB=Q8TLP7	Anthranilate synthase, component I	ISS			PTHR11236:SF9	ANTHRANILATE SYNTHASE COMPONENT 1
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IGI	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01070	K+ channel	BOVIN|Ensembl=ENSBTAG00000003030|UniProtKB=F1MCH6	Uncharacterized protein	ISS	12223552	PubMed	PTHR11537:SF6	POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P02723	Adenine and hypoxanthine salvage pathway	P02808	Deoxyadenosine phosphorylase	SCHPO|PomBase=SPAC1805.16c|UniProtKB=Q9UTG1	Putative purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00018	EGF receptor signaling pathway	P00557	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	TAKRU|Ensembl=ENSTRUG00000016101|UniProtKB=H2UW32	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01178	Grb2	CAEEL|WormBase=WBGene00004774|UniProtKB=P29355	Sex muscle abnormal protein 5	TAS	8307166	PubMed	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00006	Apoptosis signaling pathway	P00300	Caspase 7	BOVIN|Ensembl=ENSBTAG00000006615|UniProtKB=F1MD58	Uncharacterized protein	ISS	14583630	PubMed	PTHR10454:SF31	CASPASE-7
P00059	p53 pathway	P04619	HMG1	MOUSE|MGI=MGI=96113|UniProtKB=P63158	High mobility group protein B1	ISS			PTHR13711:SF164	HIGH MOBILITY GROUP PROTEIN B1-RELATED
P00030	Hypoxia response via HIF activation	P00814	P300	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00059	p53 pathway	P04633	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02736	Coenzyme A biosynthesis	P02883	Pantothenoylcysteine decarboxylase	BACSU|EnsemblGenome=BSU15700|UniProtKB=O35033	Probable coenzyme A biosynthesis bifunctional protein CoaBC	ISS			PTHR14359:SF6	PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE
P00018	EGF receptor signaling pathway	P00554	Shc	MOUSE|MGI=MGI=98296|UniProtKB=P98083	SHC-transforming protein 1	IGI	10982827	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00021	FGF signaling pathway	P00634	MEKK1-5	HUMAN|HGNC=6857|UniProtKB=Q99683	Mitogen-activated protein kinase kinase kinase 5	IGI	11730323	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00047	PDGF signaling pathway	P01152	RasGAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	ISS	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00110	Ire-1 N-terminal fragment	ARATH|TAIR=AT2G17520|UniProtKB=Q9C5S2	Serine/threonine-protein kinase/endoribonuclease IRE1a	IDA	10619423	PubMed	PTHR13954:SF6	INOSITOL-REQUIRING ENZYME-1
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00025	Hedgehog signaling pathway	P00692	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	LEIMA|EnsemblGenome=LmjF.35.3960|UniProtKB=E9AFM1	Protein kinase A catalytic subunit isoform 2	ISS	10218114	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00944	Actin	MACMU|Ensembl=ENSMMUG00000001353|UniProtKB=F7D6T8	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000008536|UniProtKB=F6WBZ5	Mitogen-activated protein kinase	ISS	15085193	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02748	Isoleucine biosynthesis	P02996	Ketol-acid reductoisomerase	BACSU|EnsemblGenome=BSU28290|UniProtKB=P37253	Ketol-acid reductoisomerase	ISS			PTHR21371:SF1	KETOL-ACID REDUCTOISOMERASE, CHLOROPLASTIC
P00025	Hedgehog signaling pathway	P00692	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	G01511	SPRY	BOVIN|Ensembl=ENSBTAG00000001774|UniProtKB=Q08E39	Protein sprouty homolog 2	ISS	12225946	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P04371	5-Hydroxytryptamine biosynthesis	P04400	Aromatic L-amino acid decarboxylase	RAT|RGD=2494|UniProtKB=P14173	Aromatic-L-amino-acid decarboxylase	IEA	107930	OMIM	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00006	Apoptosis signaling pathway	P00318	PKCs	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00059	p53 pathway	P04609	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=109211|UniProtKB=Q8BWW9	Serine/threonine-protein kinase N2	IC	10644715	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P04393	Ras Pathway	P04560	AP1	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00007	Axon guidance mediated by semaphorins	P00340	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00224	PDGF	MOUSE|MGI=MGI=97527|UniProtKB=P20033	Platelet-derived growth factor subunit A	ISS			PTHR11633:SF3	PLATELET-DERIVED GROWTH FACTOR SUBUNIT A
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00059	p53 pathway	P01480	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00036	Interleukin signaling pathway	P00986	eNOS	MACMU|Ensembl=ENSMMUG00000020437|UniProtKB=F6WEB2	Nitric oxide synthase	ISS	93055452	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00053	T cell activation	P01312	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Gene=OPRM1|UniProtKB=P79350	Mu-type opioid receptor	IDA	11259487	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00014	Cholesterol biosynthesis	P00495	Isopentenyl diphosphate delta-isomerase	HUMAN|HGNC=23487|UniProtKB=Q9BXS1	Isopentenyl-diphosphate delta-isomerase 2	ISS	6225528	gi	PTHR10885:SF1	ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE 2
P00025	Hedgehog signaling pathway	P00682	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00223	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	CHICK|Gene=PSEN2|UniProtKB=Q90X07	Presenilin-2	TAS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00021	FGF signaling pathway	P00644	p38	DROME|FlyBase=FBgn0015765|UniProtKB=O62618	Mitogen-activated protein kinase 14A	IGI	98079070	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00020	FAS signaling pathway	P00611	Gelsolin	HUMAN|HGNC=21695|UniProtKB=Q9Y6U3	Adseverin	IGI	9323209	PubMed	PTHR11977:SF78	ADSEVERIN
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00047	PDGF signaling pathway	P01160	IP3 receptor	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00005	Angiogenesis	P00223	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	IPI	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00057	Wnt signaling pathway	P01430	p53	MACMU|Ensembl=ENSMMUG00000008639|UniProtKB=P56424	Cellular tumor antigen p53	IDA	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	RCA			PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04393	Ras Pathway	P04561	SRF	BOVIN|Ensembl=ENSBTAG00000012777|UniProtKB=E1BJP4	Uncharacterized protein	ISS	15326221	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	CANLF|Ensembl=ENSCAFG00000012522|UniProtKB=E2RND9	GTP:AMP phosphotransferase AK3, mitochondrial	ISS			PTHR23359:SF68	GTP:AMP PHOSPHOTRANSFERASE AK3, MITOCHONDRIAL
P00035	Interferon-gamma signaling pathway	P00953	Jak1	MOUSE|MGI=MGI=96628|UniProtKB=P52332	Tyrosine-protein kinase JAK1	ISS	11929133	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00048	PI3 kinase pathway	P01188	Gbetagamma	HUMAN|HGNC=4401|UniProtKB=O14775	Guanine nucleotide-binding protein subunit beta-5	IC	10051575	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	PANTR|Ensembl=ENSPTRG00000018521|UniProtKB=H2QTL3	Tyrosine-protein kinase	ISS			PTHR24418:SF296	TYROSINE-PROTEIN KINASE FRK
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	CHICK|Ensembl=ENSGALG00000017238|UniProtKB=F1NWG3	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04393	Ras Pathway	P04550	Ral	MACMU|Ensembl=ENSMMUG00000016059|UniProtKB=F7GPM1	Ras-related protein Ral-A	ISS	11025226	PubMed	PTHR24070:SF174	RAS-RELATED PROTEIN RAL-A
P00012	Cadherin signaling pathway	P00477	GSK3beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00057	Wnt signaling pathway	P01443	Phospholipase C	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00011	Blood coagulation	P00452	mPAR-3	MOUSE|MGI=MGI=1298208|UniProtKB=O08675	Proteinase-activated receptor 3	ISS	20909264	gi	PTHR24232:SF0	PROTEINASE-ACTIVATED RECEPTOR 3
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PANTR|Ensembl=ENSPTRG00000012258|UniProtKB=H2QIE2	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF195	BETA-CENTRACTIN
P00049	Parkinson disease	P01208	Hsp70	BOVIN|Ensembl=ENSBTAG00000011419|UniProtKB=Q3ZCH0	Stress-70 protein, mitochondrial	ISS	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P00057	Wnt signaling pathway	P01443	Phospholipase C	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00006	Apoptosis signaling pathway	P00260	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00243	Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00021	FGF signaling pathway	P00645	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	20264070	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00029	Huntington disease	P00797	p53	MOUSE|MGI=MGI=1338801|UniProtKB=Q7TMB8	Cytoplasmic FMR1-interacting protein 1	TAS			PTHR12195:SF2	CYTOPLASMIC FMR1-INTERACTING PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MONDO|Ensembl=ENSMODG00000024440|UniProtKB=F7DJJ2	Muscarinic acetylcholine receptor	ISS	10069496	PubMed	PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00006	Apoptosis signaling pathway	P00318	PKCs	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	RAT|RGD=3425|UniProtKB=P97887	Presenilin-1	IDA	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00036	Interleukin signaling pathway	P00996	STAT	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00034	Integrin signalling pathway	P00948	Rho	MONDO|Ensembl=ENSMODG00000012981|UniProtKB=F7CS91	Uncharacterized protein	ISS	11360179	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00010	B cell activation	P00399	Ig-alpha	MOUSE|MGI=MGI=101774|UniProtKB=P11911	B-cell antigen receptor complex-associated protein alpha chain	TAS	1922076	PubMed	PTHR14334:SF1	B-CELL ANTIGEN RECEPTOR COMPLEX-ASSOCIATED PROTEIN ALPHA CHAIN
P00018	EGF receptor signaling pathway	P00556	PLCgamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1203729|UniProtKB=Q61194	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	BOVIN|Gene=DRD2|UniProtKB=P20288	D(2) dopamine receptor	ISS	2039532	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00048	PI3 kinase pathway	P01181	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05918	p38 MAPK pathway	P06031	p38alpha	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	RCA	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00010	B cell activation	P00383	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00056	VEGF signaling pathway	P01407	Erk	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9836512	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01159	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	YEAST|SGD=S000006189|UniProtKB=P32383	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00021	FGF signaling pathway	P00623	FGF	DANRE|ZFIN=ZDB-GENE-001006-1|UniProtKB=Q9DFC9	Fibroblast growth factor	ISS			PTHR11486:SF31	FIBROBLAST GROWTH FACTOR 4
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00009	Axon guidance mediated by netrin	P00363	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02725	Allantoin degradation	P02822	Allantoinase	DROME|FlyBase=FBgn0030914|UniProtKB=Q9VWW1	CG6106, isoform A	ISS			PTHR43668:SF2	ALLANTOINASE
P00034	Integrin signalling pathway	P00916	Ras	MONDO|Gene=KRAS|UniProtKB=Q07983	GTPase KRas	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00046	Oxidative stress response	P01135	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00053	T cell activation	P01300	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01153	GSK3	MOUSE|MGI=MGI=2152453|UniProtKB=Q2NL51	Glycogen synthase kinase-3 alpha	ISS	14698990	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00018	EGF receptor signaling pathway	P00564	Rac	DROME|FlyBase=FBgn0010333|UniProtKB=P40792	Ras-related protein Rac1	IGI	4757952	gi	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00010	B cell activation	P00385	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	8649368	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00006	Apoptosis signaling pathway	P00327	FADD	MOUSE|MGI=MGI=109324|UniProtKB=Q61160	FAS-associated death domain protein	IDA	9506948	PubMed	PTHR15077:SF8	FAS-ASSOCIATED DEATH DOMAIN PROTEIN
P00057	Wnt signaling pathway	P01457	GBeta	DAPPU|EnsemblGenome=DAPPUDRAFT_206575|UniProtKB=E9FUX0	Guanine nucleotide binding protein, beta subunit	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00010	B cell activation	P00391	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05913	Enkephalin release	P05974	G-Protein (i)	BOVIN|Ensembl=ENSBTAG00000006495|UniProtKB=P11017	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00057	Wnt signaling pathway	P01472	Histone deacetylase	CAEEL|WormBase=WBGene00001834|UniProtKB=O17695	Histone deacetylase 1	IDA	10485845	PubMed	PTHR10625:SF171	HISTONE DEACETYLASE 2
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06755	CBP	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	RCA	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00591	PLCbeta	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00054	Toll receptor signaling pathway	P01375	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00005	Angiogenesis	P00227	PLA2	BOVIN|Ensembl=ENSBTAG00000013298|UniProtKB=A4IFJ5	Cytosolic phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000022319|UniProtKB=F6XDA0	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00705	Gsalpha	MOUSE|MGI=MGI=95774|UniProtKB=Q8CGK7	Guanine nucleotide-binding protein G(olf) subunit alpha	ISS	2106672	PubMed	PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00539	14-3-3	ORYSJ|EnsemblGenome=OS01G0209200|UniProtKB=Q5QNB8	14-3-3-like protein GF14-G	ISS	10407019	PubMed	PTHR18860:SF32	14-3-3 FAMILY PROTEIN-RELATED
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	3035212	PubMed	PTHR24070:SF385	GTPASE HRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00928	alpha actinin	MOUSE|MGI=MGI=1890773|UniProtKB=P57780	Alpha-actinin-4	IPI	2116421	PubMed	PTHR43947:SF7	ALPHA-ACTININ-4
P05915	Opioid proenkephalin pathway	P05994	G-protein	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CANLF|Ensembl=ENSCAFG00000001738|UniProtKB=E2RDG9	Uncharacterized protein	ISS	11431030	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00029	Huntington disease	P00803	Sp1	MACMU|Ensembl=ENSMMUG00000020036|UniProtKB=F7GDJ8	Transcription factor Sp1 isoform a	RCA			PTHR23235:SF16	TRANSCRIPTION FACTOR SP1
P00053	T cell activation	P01318	PKC-theta	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00057	Wnt signaling pathway	P01443	Phospholipase C	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IDA	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	RCA	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MACMU|Ensembl=ENSMMUG00000010031|UniProtKB=F6Q193	TGF-beta receptor type-2	ISS	9395284	PubMed	PTHR23255:SF55	TGF-BETA RECEPTOR TYPE-2
P04395	Vasopressin synthesis	P04589	Signal Peptidase	ANOGA|EnsemblGenome=AGAP003069|UniProtKB=A0T4G0	Signal peptidase complex catalytic subunit SEC11	IC	2092035	PubMed	PTHR10806:SF6	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11
P00036	Interleukin signaling pathway	P00994	FKHRL1	PANTR|Ensembl=ENSPTRG00000018476|UniProtKB=H2R710	Forkhead box O3	ISS	10102273	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P02738	De novo purine biosynthesis	P02909	GDP reductase	CANLF|Ensembl=ENSCAFG00000005945|UniProtKB=E2R8P1	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	MOUSE|MGI=MGI=99684|UniProtKB=A2AGL3	Ryanodine receptor 3	ISS	15226293	PubMed	PTHR13715:SF16	RYANODINE RECEPTOR 3
P00025	Hedgehog signaling pathway	P00692	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04393	Ras Pathway	P04542	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00568	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	IGI	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P02752	Mannose metabolism	P03018	Mannose 1-P guanylyl transferase	YEAST|SGD=S000002213|UniProtKB=P41940	Mannose-1-phosphate guanyltransferase	NAS	894204	gi	PTHR22572:SF15	MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE BETA
P06214	GBB signaling pathway	P06298	FUR1	DROME|FlyBase=FBgn0004509|UniProtKB=P26016	Furin-like protease 1, isoforms 1/1-X/2	IEA	10956649	PubMed	PTHR42884:SF3	FURIN-LIKE PROTEASE 1, ISOFORMS 1/1-X/2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	HUMAN|HGNC=3025|UniProtKB=P21917	D(4) dopamine receptor	ISS	1319557	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00056	VEGF signaling pathway	P01414	PLC-gamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	HUMAN|HGNC=1404|UniProtKB=O00305	Voltage-dependent L-type calcium channel subunit beta-4	IC			PTHR11824:SF7	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00054	Toll receptor signaling pathway	P01360	IKKbeta	BOVIN|Ensembl=ENSBTAG00000007599|UniProtKB=Q95KV0	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00006	Apoptosis signaling pathway	P00257	Bcl-xL	HUMAN|HGNC=992|UniProtKB=Q07817	Bcl-2-like protein 1	ISS	7828536	PubMed	PTHR11256:SF12	BCL-2-LIKE PROTEIN 1
P00053	T cell activation	P01315	Calcineurin	BOVIN|Ensembl=ENSBTAG00000016005|UniProtKB=P48452	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	IGI	12091710	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00778	NMDA receptor	MACMU|Ensembl=ENSMMUG00000001661|UniProtKB=F7GR69	Uncharacterized protein	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	CANLF|Ensembl=ENSCAFG00000017040|UniProtKB=E2QYK5	Uncharacterized protein	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01236	Casein kinase II	CANAL|CGD=CAL0005264|UniProtKB=Q5ACW5	Casein kinase II subunit beta	IDA	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00053	T cell activation	P01322	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04630	PP2A	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	88107662	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	CANLF|Ensembl=ENSCAFG00000006059|UniProtKB=F1Q126	Uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00036	Interleukin signaling pathway	P00964	p90RSK	CHICK|Ensembl=ENSGALG00000011473|UniProtKB=F1P1H2	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00056	VEGF signaling pathway	P01408	Akt/PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	IDA	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00162	Pro-BACE-1	BOVIN|Ensembl=ENSBTAG00000019365|UniProtKB=Q2HJ40	Beta-secretase 1	ISS	10956649	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00627	ERK1-2	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	RAT|RGD=3425|UniProtKB=P97887	Presenilin-1	TAS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00046	Oxidative stress response	P01129	JNK1/2	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	RAT|RGD=1311985|UniProtKB=B2GV73	Actin-related protein 2/3 complex subunit 3	ISS	12473693	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00057	Wnt signaling pathway	P01455	Smad4	DANRE|ZFIN=ZDB-GENE-991119-8|UniProtKB=Q9I8V2	Mothers against decapentaplegic homolog 1	IDA	9395284	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	HUMAN|HGNC=4388|UniProtKB=P38405	Guanine nucleotide-binding protein G(olf) subunit alpha	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00925	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00057	Wnt signaling pathway	P01444	Wnt	PANTR|Ensembl=ENSPTRG00000004892|UniProtKB=H2Q5U3	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00012	Cadherin signaling pathway	P00466	EGFR	MONDO|Ensembl=ENSMODG00000015755|UniProtKB=F6ZSZ9	Uncharacterized protein (Fragment)	ISS	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=97439|UniProtKB=P33534	Kappa-type opioid receptor	IDA	11259498	PubMed	PTHR24229:SF1	KAPPA-TYPE OPIOID RECEPTOR
P00034	Integrin signalling pathway	P00927	Rac	ENTHI|EnsemblGenome=EHI_129750|UniProtKB=C4M5Q7	Rho family GTPase	IGI	4757952	gi	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	MACMU|Ensembl=ENSMMUG00000013047|UniProtKB=F7H808	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	PANTR|Ensembl=ENSPTRG00000022245|UniProtKB=H2QZ29	Uncharacterized protein	ISS	20112749	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00006	Apoptosis signaling pathway	P00303	c-Jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00034	Integrin signalling pathway	P00919	Arf6	BOVIN|Ensembl=ENSBTAG00000045980|UniProtKB=G3N3N1	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	ARATH|TAIR=AT1G59580|UniProtKB=Q39022	Mitogen-activated protein kinase 2	ISS			PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00057	Wnt signaling pathway	P01454	betaTrCP	CHICK|Ensembl=ENSGALG00000007820|UniProtKB=F1NYG1	Uncharacterized protein	ISS	10074433	PubMed	PTHR44038:SF2	F-BOX/WD REPEAT-CONTAINING PROTEIN 1A
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05730	Endogenous cannabinoid signaling	P05751	Galpha	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00029	Huntington disease	P00790	beta-Tubulin	MONDO|Ensembl=ENSMODG00000024011|UniProtKB=F7CGM4	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00048	PI3 kinase pathway	P01185	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00053	T cell activation	P01306	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00053	T cell activation	P01324	rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12874273	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	DANRE|ZFIN=ZDB-GENE-990415-257|UniProtKB=O42376	Mitogen-activated protein kinase 12	ISS	10514528	PubMed	PTHR24055:SF339	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	IDA	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01174	Rho	RAT|RGD=1564816|UniProtKB=D3ZU63	Protein Stard13	ISS			PTHR12659:SF6	STAR-RELATED LIPID TRANSFER PROTEIN 13
P06664	Gonadotropin-releasing hormone receptor pathway	P06713	Nur77	MOUSE|MGI=MGI=1352454|UniProtKB=P12813	Nuclear receptor subfamily 4 group A member 1	RCA			PTHR24085:SF1	NUCLEAR RECEPTOR SUBFAMILY 4 GROUP A MEMBER 1
P00006	Apoptosis signaling pathway	P00306	TRAF2	RAT|RGD=1310457|UniProtKB=B5DFH7	Protein Traf2	ISS			PTHR10131:SF21	TNF RECEPTOR-ASSOCIATED FACTOR 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	TAS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00059	p53 pathway	P04633	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00546	GAP	MACMU|Ensembl=ENSMMUG00000008605|UniProtKB=F6UAM4	Uncharacterized protein	ISS	18587532	gi	PTHR10194:SF60	NEUROFIBROMIN
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	RCA	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05730	Endogenous cannabinoid signaling	P05748	mGluR	RAT|RGD=2746|UniProtKB=P31424	Metabotropic glutamate receptor 5	ISS	12488551	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00029	Huntington disease	P00780	Microtubule	ORNAN|Ensembl=ENSOANG00000004061|UniProtKB=F6TYN8	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P00034	Integrin signalling pathway	P00936	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	IPI	14526383	PubMed	PTHR10048:SF14	PI-3 KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P02724	Alanine biosynthesis	P02815	Branched chain amino acid aminotransferase	BOVIN|Ensembl=ENSBTAG00000009172|UniProtKB=Q5EA40	Branched-chain-amino-acid aminotransferase, mitochondrial	ISS			PTHR11825:SF39	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, MITOCHONDRIAL
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	MACMU|Ensembl=ENSMMUG00000014486|UniProtKB=F7GH95	Ras-related protein Rap-1A	ISS	1904317	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00034	Integrin signalling pathway	P00924	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=17293|UniProtKB=Q9BZL6	Serine/threonine-protein kinase D2	ISS	11062248	PubMed	PTHR22968:SF12	SERINE/THREONINE-PROTEIN KINASE D2
P00012	Cadherin signaling pathway	P00474	Wnt	RAT|RGD=1305018|UniProtKB=D3ZF63	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ORYSJ|EnsemblGenome=OS03G0718100|UniProtKB=Q10DV7	Actin-1	ISS	14684598	PubMed	PTHR11937:SF364	ACTIN-11
P00034	Integrin signalling pathway	P00907	ERK	MONDO|Ensembl=ENSMODG00000001962|UniProtKB=F6V2H6	Uncharacterized protein	ISS	8444355	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00029	Huntington disease	P00800	PolyQ Htt	MACMU|Ensembl=ENSMMUG00000008392|UniProtKB=F6VQZ3	Uncharacterized protein	ISS	9462744	PubMed	PTHR10170:SF10	HUNTINGTIN
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00590	IP3 R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01322	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	PANTR|Ensembl=ENSPTRG00000001854|UniProtKB=H2Q0X1	Uncharacterized protein	ISS	SYT2_RAT	SPACC	PTHR10024:SF223	SYNAPTOTAGMIN-2
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	HUMAN|HGNC=173|UniProtKB=P27037	Activin receptor type-2A	TAS	9395284	PubMed	PTHR23255:SF64	ACTIVIN RECEPTOR TYPE-2A
P00005	Angiogenesis	P00223	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00181	SHP2	BOVIN|Ensembl=ENSBTAG00000002048|UniProtKB=F1N339	Tyrosine-protein phosphatase non-receptor type	ISS	14525967	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00057	Wnt signaling pathway	P01444	Wnt	CHICK|Ensembl=ENSGALG00000005410|UniProtKB=Q9YGX6	Protein Wnt	IDA	11266476	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CAEBR|Gene=CBG02167|UniProtKB=A8WS37	Protein CBG02167	ISS	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00012	Cadherin signaling pathway	P00477	GSK3beta	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	IDA	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	MOUSE|MGI=MGI=104755|UniProtKB=P48545	G protein-activated inward rectifier potassium channel 4	ISS	2433589	PubMed	PTHR11767:SF52	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 4
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00019	Endothelin signaling pathway	P00587	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00624	14-3-3	CANLF|Ensembl=ENSCAFG00000013549|UniProtKB=E2QVP6	Uncharacterized protein	ISS	91108808	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05730	Endogenous cannabinoid signaling	P05746	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IC	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00922	Collagen	CANLF|Gene=COL1A1|UniProtKB=Q9XSJ7	Collagen alpha-1(I) chain	IDA	10778855	PubMed	PTHR24023:SF569	COLLAGEN ALPHA-1 I  CHAIN
P02747	Histidine biosynthesis	P02988	Histidinal dehydrogenase	STRCO|EnsemblGenome=CAB51446|UniProtKB=P16245	Histidinol dehydrogenase	ISS			PTHR21256:SF2	HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00016	Cytoskeletal regulation by Rho GTPase	P00519	ROCK	CAEEL|WormBase=WBGene00002694|UniProtKB=P92199	Rho-associated protein kinase let-502	ISS			PTHR22988:SF38	RHO-ASSOCIATED PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	RAT|RGD=3188|UniProtKB=Q9QW30	Neurogenic locus notch homolog protein 2	IDA	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00010	B cell activation	P00381	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00010	B cell activation	P00375	Calmodulin	TAKRU|Ensembl=ENSTRUG00000003442|UniProtKB=H2S6Q5	Uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF197	CALMODULIN-LIKE PROTEIN 3
P05914	Nicotine degradation	P05982	UGT1A4	HUMAN|HGNC=12537|UniProtKB=P35504	UDP-glucuronosyltransferase 1-5	TAS	12433823	PubMed	PTHR11926:SF173	UDP-GLUCURONOSYLTRANSFERASE 1-3-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	IGI	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P02742	Tetrahydrofolate biosynthesis	P02944	Phosphoribosylglycinamide formyltransferase	PSEAE|EnsemblGenome=PA5420|UniProtKB=Q9HTE4	Formyltetrahydrofolate deformylase	ISS			PTHR42706:SF1	FORMYLTETRAHYDROFOLATE DEFORMYLASE 1, MITOCHONDRIAL-RELATED
P00029	Huntington disease	P00776	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00053	T cell activation	P01300	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04374	5HT2 type receptor mediated signaling pathway	P04413	K+ channel	MACMU|Ensembl=ENSMMUG00000005826|UniProtKB=F6VE51	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00048	PI3 kinase pathway	P01189	PTEN	CAEEL|WormBase=WBGene00000913|UniProtKB=G5EE01	DAF-18	TAS	9885576	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	HUMAN|HGNC=3025|UniProtKB=P21917	D(4) dopamine receptor	IDA	1319557	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	RCA	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	XENTR|Xenbase=XB-GENE-987058|UniProtKB=F7BRA8	Uncharacterized protein	ISS			PTHR11699:SF140	RETINAL DEHYDROGENASE 1
P05913	Enkephalin release	P05977	G-Protein (s)	MACMU|Ensembl=ENSMMUG00000010266|UniProtKB=F6PV18	Uncharacterized protein	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00979	MAPKAPK2	PANTR|Ensembl=ENSPTRG00000001915|UniProtKB=H2Q104	Mitogen-activated protein kinase-activated protein kinase 2	ISS	10779545	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00036	Interleukin signaling pathway	P00965	ERK	RAT|RGD=621505|UniProtKB=P0C865	Mitogen-activated protein kinase 7	ISS	12912994	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00012	Cadherin signaling pathway	P00475	Frizzled	BOVIN|Ensembl=ENSBTAG00000020742|UniProtKB=F1MBL4	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF79	FRIZZLED-9
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CHICK|Gene=CHRM4|UniProtKB=P17200	Muscarinic acetylcholine receptor M4	IDA	8100450	PubMed	PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00243	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04557	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	IDA	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00006	Apoptosis signaling pathway	P00260	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=1306856|UniProtKB=Q5DWV2	Cadherin-7	ISS	8120095	PubMed	PTHR24027:SF91	CADHERIN-7
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05731	GABA-B receptor II signaling	P05760	AC	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00019	Endothelin signaling pathway	P00585	ECE1-3	HUMAN|HGNC=3146|UniProtKB=P42892	Endothelin-converting enzyme 1	IGI	12464614	PubMed	PTHR11733:SF130	ENDOTHELIN-CONVERTING ENZYME 1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00023	General transcription regulation	P00658	TBP-associated factors	HUMAN|HGNC=11540|UniProtKB=P49848	Transcription initiation factor TFIID subunit 6	ISS			PTHR10221:SF12	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IGI	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00973	PKB	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	G01579	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00054	Toll receptor signaling pathway	P01356	ERK2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01154	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	3035212	PubMed	PTHR24070:SF385	GTPASE HRAS
P00046	Oxidative stress response	P01123	Bcl-2	PANTR|Ensembl=ENSPTRG00000010079|UniProtKB=H2QEM8	B-cell CLL/lymphoma 2	ISS	11323415	PubMed	PTHR11256:SF11	APOPTOSIS REGULATOR BCL-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05918	p38 MAPK pathway	P06013	ELK	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	11279280	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00018	EGF receptor signaling pathway	P00565	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	RAT|RGD=2732|UniProtKB=P22756	Glutamate receptor ionotropic, kainate 1	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00020	FAS signaling pathway	P00620	CytochromeC	BOVIN|Ensembl=ENSBTAG00000012232|UniProtKB=P00125	Cytochrome c1, heme protein, mitochondrial	ISS	15163634	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00005	Angiogenesis	P00213	FGF	MACMU|Ensembl=ENSMMUG00000023509|UniProtKB=F7E243	Fibroblast growth factor	ISS	12057924	PubMed	PTHR11486:SF86	FIBROBLAST GROWTH FACTOR 1
P00053	T cell activation	P01333	cdc42	HUMAN|HGNC=1736|UniProtKB=P60953	Cell division control protein 42 homolog	IDA	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IGI	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02747	Histidine biosynthesis	P02988	Histidinal dehydrogenase	NEUCR|EnsemblGenome=EFNCRG00000002822|UniProtKB=P07685	Histidine biosynthesis trifunctional protein	ISS			PTHR21256:SF2	HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN
P00018	EGF receptor signaling pathway	P00547	PP2A	BOVIN|Ensembl=ENSBTAG00000020192|UniProtKB=A4FV55	PPP2R5C protein	ISS	10092233	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MOUSE|MGI=MGI=2150393|UniProtKB=Q91ZU9	Glutamate receptor ionotropic, NMDA 3B	IC	11319238	PubMed	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P04392	P53 pathway feedback loops 1	P04536	Mdm2	MOUSE|MGI=MGI=107934|UniProtKB=O35618	Protein Mdm4	ISS			PTHR13844:SF20	PROTEIN MDM4
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00249	PAK	RAT|RGD=3250|UniProtKB=P35465	Serine/threonine-protein kinase PAK 1	ISS	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	PYRAE|EnsemblGenome=PAE0947|UniProtKB=Q8ZY48	Carbamoyl-phosphate synthase large chain	ISS			PTHR11405:SF5	CAD PROTEIN
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000012922|UniProtKB=H2QJF2	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P06664	Gonadotropin-releasing hormone receptor pathway	P06842	KSR-1	MOUSE|MGI=MGI=105051|UniProtKB=Q61097	Kinase suppressor of Ras 1	RCA			PTHR44174:SF2	KINASE SUPPRESSOR OF RAS 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	BOVIN|Ensembl=ENSBTAG00000037616|UniProtKB=F1MUD1	Uncharacterized protein	ISS	12374786	PubMed	PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	CHICK|Ensembl=ENSGALG00000010529|UniProtKB=O93345	Lymphiod enhancer binding factor 1	TAS	11266476	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00006	Apoptosis signaling pathway	P00274	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00036	Interleukin signaling pathway	P00965	ERK	RAT|RGD=621505|UniProtKB=P0C865	Mitogen-activated protein kinase 7	ISS	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_125401|UniProtKB=C3ZTX6	Putative uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	RAT|RGD=621705|UniProtKB=Q8VHN2	Glutamate receptor ionotropic, NMDA 3B	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	ISS	7925653	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MOUSE|MGI=MGI=101848|UniProtKB=P62881	Guanine nucleotide-binding protein subunit beta-5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	RAT|RGD=61800|UniProtKB=P14842	5-hydroxytryptamine receptor 2A	ISS	8143856	PubMed	PTHR24247:SF30	5-HYDROXYTRYPTAMINE RECEPTOR 2A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04547	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IDA	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P00035	Interferon-gamma signaling pathway	P00960	PTP	PANTR|Ensembl=ENSPTRG00000042397|UniProtKB=H2RIH8	Tyrosine-protein phosphatase non-receptor type	ISS	95163101	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00029	Huntington disease	P00774	Dynein complex	RAT|RGD=619866|UniProtKB=P63170	Dynein light chain 1, cytoplasmic	ISS	9454836	PubMed	PTHR11886:SF52	DYNEIN LIGHT CHAIN 1, CYTOPLASMIC
P00020	FAS signaling pathway	P00615	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	PANTR|Ensembl=ENSPTRG00000017238|UniProtKB=H2QRH7	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	BOVIN|Ensembl=ENSBTAG00000007909|UniProtKB=F1MPE9	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P04623	CBP	PANTR|Ensembl=ENSPTRG00000014418|UniProtKB=H2QLS0	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00010	B cell activation	P00379	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00359	NFAT	PANTR|Ensembl=ENSPTRG00000013628|UniProtKB=H2R4F5	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00024	Glycolysis	P00679	Aldolase	RAT|RGD=1359133|UniProtKB=Q6AY07	Fructose-bisphosphate aldolase	ISS	6086339	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00021	FGF signaling pathway	P00624	14-3-3	NEUCR|EnsemblGenome=EFNCRG00000002359|UniProtKB=Q7RVK6	14-3-3 family protein 7	ISS	12063166	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	10875333	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00019	Endothelin signaling pathway	P00580	ET-RA/B	MOUSE|MGI=MGI=105923|UniProtKB=Q61614	Endothelin-1 receptor	ISS	91195317	PubMed	PTHR24243:SF31	ENDOTHELIN-1 RECEPTOR
P00021	FGF signaling pathway	P00633	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00977	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00006	Apoptosis signaling pathway	P00291	MEKK1	RAT|RGD=620966|UniProtKB=Q62925	Mitogen-activated protein kinase kinase kinase 1	ISS	12049732	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00015	Circadian clock system	P00504	Per	HUMAN|HGNC=8845|UniProtKB=O15534	Period circadian protein homolog 1	ISS	20570170	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MACMU|Ensembl=ENSMMUG00000009341|UniProtKB=F6UA54	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	IDA	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IC	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00005	Angiogenesis	P00223	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00010	B cell activation	P00381	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00289	FAS	HUMAN|HGNC=11920|UniProtKB=P25445	Tumor necrosis factor receptor superfamily member 6	IDA	14676844	PubMed	PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00023	General transcription regulation	P00668	TFIIB	HUMAN|HGNC=17298|UniProtKB=Q9HAW0	Transcription factor IIIB 50 kDa subunit	ISS			PTHR11618:SF5	TRANSCRIPTION FACTOR IIIB 50 KDA SUBUNIT
P00010	B cell activation	P00372	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	8051109	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	RAT|RGD=2831|UniProtKB=P25102	Histamine H2 receptor	IDA	8817552	PubMed	PTHR43893:SF5	HISTAMINE H2 RECEPTOR
P00057	Wnt signaling pathway	P01444	Wnt	MONDO|Ensembl=ENSMODG00000001196|UniProtKB=F7GH85	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00036	Interleukin signaling pathway	P00975	RasGAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	ISS	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	YEAST|SGD=S000005901|UniProtKB=P46367	Potassium-activated aldehyde dehydrogenase, mitochondrial	IC			PTHR11699:SF268	MAGNESIUM-ACTIVATED ALDEHYDE DEHYDROGENASE, CYTOSOLIC-RELATED
P00018	EGF receptor signaling pathway	P00539	14-3-3	TAKRU|Ensembl=ENSTRUG00000004697|UniProtKB=H2SFG7	Uncharacterized protein	ISS	91108808	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	9199552	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P06664	Gonadotropin-releasing hormone receptor pathway	P06849	Sos	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	RCA	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00021	FGF signaling pathway	P00629	PP2A	RAT|RGD=1305657|UniProtKB=A0A0G2JTA1	Protein Ppp2r5e	ISS	8703017	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P04397	p53 pathway by glucose deprivation	P04641	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04546	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	IDA	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00059	p53 pathway	G01575	GADD45	BOVIN|Ensembl=ENSBTAG00000013860|UniProtKB=Q3ZBN6	Growth arrest and DNA damage-inducible protein GADD45 alpha	ISS	10097101	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	BOVIN|Ensembl=ENSBTAG00000016420|UniProtKB=Q0VCX4	Catenin beta-1	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00022	General transcription by RNA polymerase I	P00657	TBP	PANTR|Ensembl=ENSPTRG00000018624|UniProtKB=A6H914	TATA box binding protein-like 1	ISS	600075	OMIM	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	ORNAN|Ensembl=ENSOANG00000005917|UniProtKB=F6QM53	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02766	Phenylethylamine degradation	P03103	Phenylethylamine oxidase	RAT|RGD=2644|UniProtKB=P43428	Glucose-6-phosphatase	ISS			PTHR12591:SF3	GLUCOSE-6-PHOSPHATASE
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	PSEAE|EnsemblGenome=PA4724|UniProtKB=Q9HV75	Glutamyl-Q tRNA(Asp) synthetase	ISS			PTHR43311:SF1	GLUTAMYL-Q TRNA ASP  SYNTHETASE
P00017	DNA replication	P00533	Pol delta	PANTR|Ensembl=ENSPTRG00000019138|UniProtKB=G2HH55	DNA polymerase subunit delta 2	ISS	12522211	PubMed	PTHR10416:SF0	DNA POLYMERASE DELTA SUBUNIT 2
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	IC	91072385	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P05918	p38 MAPK pathway	P06021	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	10802295	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	PANTR|Ensembl=ENSPTRG00000000843|UniProtKB=H2QZN8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00012	Cadherin signaling pathway	P00470	F-actin	SCHMA|EnsemblGenome=Smp_161920|UniProtKB=G4VSW5	Putative actin	IC	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00021	FGF signaling pathway	P00629	PP2A	CHICK|Ensembl=ENSGALG00000007565|UniProtKB=F1NS72	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B	ISS	12110603	PubMed	PTHR11871:SF1	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B BETA ISOFORM
P00059	p53 pathway	P01486	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_114976|UniProtKB=C3YP58	Putative uncharacterized protein	IDA	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00036	Interleukin signaling pathway	P00990	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00748	Gbeta5L	CANLF|Ensembl=ENSCAFG00000015662|UniProtKB=E2RHY4	Uncharacterized protein	ISS	10051575	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00059	p53 pathway	P01486	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01199	Galpha	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	IC	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_206575|UniProtKB=E9FUX0	Guanine nucleotide binding protein, beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00047	PDGF signaling pathway	P01159	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00029	Huntington disease	P00778	NMDA receptor	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	IDA	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00006	Apoptosis signaling pathway	P00289	FAS	HUMAN|HGNC=11920|UniProtKB=P25445	Tumor necrosis factor receptor superfamily member 6	IDA	1375228	PubMed	PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	BOVIN|Ensembl=ENSBTAG00000000231|UniProtKB=F1MCE7	Receptor protein serine/threonine kinase	ISS			PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P05918	p38 MAPK pathway	P06043	ASK1	MOUSE|MGI=MGI=1346876|UniProtKB=O35099	Mitogen-activated protein kinase kinase kinase 5	TAS	12566458	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00968	Ikk	HUMAN|HGNC=5960|UniProtKB=O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	IDA	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00004	Alzheimer disease-presenilin pathway	P00131	HAC1	BOVIN|Ensembl=ENSBTAG00000008816|UniProtKB=A4IF63	Tripartite motif-containing protein 2	ISS			PTHR44028:SF2	TRIPARTITE MOTIF-CONTAINING PROTEIN 2
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	ISS	1482697	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	IDA	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00053	T cell activation	P01306	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	ANOGA|EnsemblGenome=AGAP010442|UniProtKB=Q7QDV6	AGAP010442-PA	TAS	8717036	PubMed	PTHR11309:SF90	FRIZZLED-8
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	ORNAN|Ensembl=ENSOANG00000010658|UniProtKB=F6V2V1	Uncharacterized protein	ISS	2779569	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P06959	CCKR signaling map	P07177	PKCbeta	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	RCA	7487955	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	G04694	p110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00564	Rac	CAEEL|WormBase=WBGene00000424|UniProtKB=Q03206	Ras-related protein ced-10	ISS	4757952	gi	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00010	B cell activation	P00396	CD45	HUMAN|HGNC=9666|UniProtKB=P08575	Receptor-type tyrosine-protein phosphatase C	IGI	1672451	PubMed	PTHR19134:SF284	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00038	JAK/STAT signaling pathway	P01027	STAT	MOUSE|MGI=MGI=103036|UniProtKB=P42230	Signal transducer and activator of transcription 5A	ISS	22320921	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00021	FGF signaling pathway	P00641	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	DROME|FlyBase=FBgn0087012|UniProtKB=Q8IPN2	5-hydroxytryptamine (Serotonin) receptor 2A, isoform B	IDA	12181435	PubMed	PTHR24247:SF125	5-HYDROXYTRYPTAMINE  SEROTONIN  RECEPTOR 2A, ISOFORM B
P00034	Integrin signalling pathway	P00917	ELMO	RAT|RGD=1305784|UniProtKB=G3V982	Engulfment and cell motility 2, ced-12 homolog (C. elegans), isoform CRA_b	ISS	12879077	PubMed	PTHR12771:SF8	ENGULFMENT AND CELL MOTILITY PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	XENTR|Xenbase=XB-GENE-5753573|UniProtKB=F6WKZ2	Uncharacterized protein (Fragment)	ISS			PTHR24241:SF123	SUBFAMILY NOT NAMED
P00053	T cell activation	P01311	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00059	p53 pathway	P01486	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=2136739|UniProtKB=Q91XZ5	Protein Pcdhb5	IDA	8120095	PubMed	PTHR24028:SF55	PROTOCADHERIN BETA-4
P00010	B cell activation	P00369	MEKK	MONDO|Ensembl=ENSMODG00000009983|UniProtKB=F6USY2	Uncharacterized protein	ISS	9006902	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	BOVIN|Ensembl=ENSBTAG00000040329|UniProtKB=F1MMU1	Uncharacterized protein	ISS	14645495	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00049	Parkinson disease	P01235	Fyn kinase	MONDO|Ensembl=ENSMODG00000017905|UniProtKB=F7FG65	Tyrosine-protein kinase	ISS	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00010	B cell activation	P00384	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00005	Angiogenesis	P00190	RasGAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	14707121	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	CANLF|Ensembl=ENSCAFG00000010476|UniProtKB=F1PS94	Uncharacterized protein	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00012	Cadherin signaling pathway	P00470	F-actin	CHICK|Ensembl=ENSGALG00000014620|UniProtKB=F1N8P3	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P02757	O-antigen biosynthesis	P03046	dTDP-glucose pyrophosphorylase	DEIRA|EnsemblGenome=DR_A0042|UniProtKB=Q9RZB2	Glucose-1-phosphate thymidylyltransferase	ISS			PTHR43532:SF1	GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE 1
P00053	T cell activation	P01306	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00024	Glycolysis	P00678	Enolase	BOVIN|Gene=ENO1|UniProtKB=Q9XSJ4	Alpha-enolase	ISS	89079778	PubMed	PTHR11902:SF12	ALPHA-ENOLASE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00057	Wnt signaling pathway	P01453	Ebi	CHICK|Ensembl=ENSGALG00000013366|UniProtKB=E1BV27	Uncharacterized protein	ISS	11389839	PubMed	PTHR22846:SF2	F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN TBL1X
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P06664	Gonadotropin-releasing hormone receptor pathway	P06841	gnaq/11	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	RCA	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02756	N-acetylglucosamine metabolism	P03039	Glucosamine-1-phosphate acetyltransferase	BACSU|EnsemblGenome=BSU00500|UniProtKB=P14192	Bifunctional protein GlmU	ISS			PTHR43584:SF3	BIFUNCTIONAL PROTEIN GLMU
P05918	p38 MAPK pathway	P06032	MKK6	HUMAN|HGNC=6846|UniProtKB=P52564	Dual specificity mitogen-activated protein kinase kinase 6	RCA	8622669	PubMed	PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	HUMAN|HGNC=7601|UniProtKB=Q8NEV4	Myosin-IIIa	ISS			PTHR13140:SF387	MYOSIN-IIIA
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00938	Cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000010094|UniProtKB=H2QEN7	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF91	CADHERIN-7
P00019	Endothelin signaling pathway	P00572	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	CANLF|Gene=DRD2|UniProtKB=Q9GJU1	D(2) dopamine receptor	ISS	11861492	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00048	PI3 kinase pathway	P01192	p110	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02730	Asparagine and aspartate biosynthesis	P02853	Asparagine synthetase	PANTR|Ensembl=ENSPTRG00000019429|UniProtKB=H2QUZ4	Asparagine synthetase	ISS			PTHR11772:SF23	ASPARAGINE SYNTHETASE  GLUTAMINE-HYDROLYZING
P04393	Ras Pathway	P04559	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00047	PDGF signaling pathway	P01157	MAPKAPK2	BOVIN|Ensembl=ENSBTAG00000038107|UniProtKB=F1MCX5	Uncharacterized protein	ISS	9628873	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	TAS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P04395	Vasopressin synthesis	P04593	Glycopeptide	MOUSE|MGI=MGI=97453|UniProtKB=P35454	Oxytocin-neurophysin 1	IC	192340	OMIM	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00021	FGF signaling pathway	P00627	ERK1-2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=1351344|UniProtKB=Q68ED2	Metabotropic glutamate receptor 7	ISS	11431030	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P05916	Opioid prodynorphin pathway	P06002	G-protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00920	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00006	Apoptosis signaling pathway	P00318	PKCs	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00193	SOS-1	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00023	General transcription regulation	P00662	TFIIA complex	ORYSJ|EnsemblGenome=OS05G0107700|UniProtKB=Q0DLD3	Transcription initiation factor IIA subunit 2	ISS			PTHR10966:SF0	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01336	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IGI	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00005	Angiogenesis	P00212	EphR	DANRE|ZFIN=ZDB-GENE-990415-60|UniProtKB=O13147	Ephrin type-B receptor 3 (Fragment)	ISS			PTHR24416:SF497	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	RAT|RGD=1304575|UniProtKB=B5DF98	Map3k3 protein	ISS	11730323	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00053	T cell activation	P01305	Calmodulin	MONDO|Ensembl=ENSMODG00000023174|UniProtKB=F7D7P2	Uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF197	CALMODULIN-LIKE PROTEIN 3
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00006	Apoptosis signaling pathway	P00292	IkappaB	RAT|RGD=3171|UniProtKB=Q63746	NF-kappa-B inhibitor alpha	ISS	12637573	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00052	TGF-beta signaling pathway	P01275	P38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	TAS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00057	Wnt signaling pathway	P01457	GBeta	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IDA	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04397	p53 pathway by glucose deprivation	P04642	Rheb	HUMAN|HGNC=10011|UniProtKB=Q15382	GTP-binding protein Rheb	IDA	12842888	PubMed	PTHR24070:SF264	GTP-BINDING PROTEIN RHEB
P02721	ATP synthesis	P02791	F1 alpha	MOUSE|MGI=MGI=88115|UniProtKB=Q03265	ATP synthase subunit alpha, mitochondrial	ISS	2527557	PubMed	PTHR43089:SF3	ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL
P00021	FGF signaling pathway	P00643	Raf-1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01202	p85	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05916	Opioid prodynorphin pathway	P06002	G-protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02783	Tryptophan biosynthesis	P03206	Anthranilate synthase	ARATH|TAIR=AT5G57890|UniProtKB=Q9FJM5	Anthranilate synthase beta subunit 2, chloroplastic	RCA			PTHR43418:SF6	ANTHRANILATE SYNTHASE BETA SUBUNIT-RELATED
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	FUSNN|EnsemblGenome=FN1152|UniProtKB=Q8REF4	Aspartate aminotransferase	ISS			PTHR43795:SF5	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00012	Cadherin signaling pathway	P00474	Wnt	TAKRU|Ensembl=ENSTRUG00000000172|UniProtKB=H2RJP1	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF103	PROTEIN WNT-4A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00702	CPB	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	RCA			PTHR13808:SF5	CREB-BINDING PROTEIN
P00006	Apoptosis signaling pathway	P00269	MAPK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01457	GBeta	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IDA	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	TAKRU|Ensembl=ENSTRUG00000000313|UniProtKB=H2RKP2	Clathrin heavy chain	ISS	9388255	PubMed	PTHR10292:SF1	CLATHRIN HEAVY CHAIN
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	IDA	12846562	PubMed	PTHR10202:SF13	PRESENILIN-2
P00012	Cadherin signaling pathway	P00462	Casein kinase II	DROME|FlyBase=FBgn0000259|UniProtKB=P08182	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P06959	CCKR signaling map	P07119	MAPK3	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	RCA	9324163	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00564	Rac	DICPU|Gene=DICPUDRAFT_55703|UniProtKB=F0ZN94	Putative uncharacterized protein racC	ISS	8649368	PubMed	PTHR24072:SF117	RHO-RELATED PROTEIN RACC
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MONDO|Ensembl=ENSMODG00000001933|UniProtKB=F6W0P2	Uncharacterized protein (Fragment)	ISS	10188796	PubMed	PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P00021	FGF signaling pathway	P00629	PP2A	BOVIN|Ensembl=ENSBTAG00000009245|UniProtKB=Q0P594	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CHICK|Ensembl=ENSGALG00000017178|UniProtKB=F1N982	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00381	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	3449797	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00012	Cadherin signaling pathway	P00465	TCF/LEF	MOUSE|MGI=MGI=1202879|UniProtKB=Q924A0	Transcription factor 7-like 2	ISS	12356903	PubMed	PTHR10373:SF32	TRANSCRIPTION FACTOR 7-LIKE 2
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	MOUSE|MGI=MGI=1338883|UniProtKB=Q9Z2Z9	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2	ISS			PTHR10937:SF10	GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE  ISOMERIZING  2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00018	EGF receptor signaling pathway	P00546	GAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	IGI	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05913	Enkephalin release	P05972	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00976	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IPI	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00048	PI3 kinase pathway	P01177	P110ACT	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05994	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06212	DPP-SCW signaling pathway	P06271	MAD	DROME|FlyBase=FBgn0011648|UniProtKB=P42003	Protein mothers against dpp	IGI	9395284	PubMed	PTHR13703:SF40	PROTEIN MOTHERS AGAINST DPP
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	TAKRU|Ensembl=ENSTRUG00000008482|UniProtKB=H2T992	Uncharacterized protein	ISS	6522685	gi	PTHR10773:SF12	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DICDI|dictyBase=DDB_G0275023|UniProtKB=Q553U6	Putative actin-22	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00006	Apoptosis signaling pathway	P00264	c-IAP1,2	MOUSE|MGI=MGI=1197009|UniProtKB=Q62210	Baculoviral IAP repeat-containing protein 2	ISS			PTHR10044:SF79	BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 2
P00021	FGF signaling pathway	P00632	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00048	PI3 kinase pathway	P01190	PDK1 ACT	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	IDA	9094314	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00006	Apoptosis signaling pathway	P00260	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P06959	CCKR signaling map	G07275	MCL1	HUMAN|HGNC=6943|UniProtKB=Q07820	Induced myeloid leukemia cell differentiation protein Mcl-1	RCA	9880563	PubMed	PTHR11256:SF46	INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN MCL-1
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01440	Cadherin	MONDO|Ensembl=ENSMODG00000004905|UniProtKB=F7C1R7	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF84	CADHERIN-20
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00046	Oxidative stress response	P01129	JNK1/2	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	XENTR|Xenbase=XB-GENE-876138|UniProtKB=Q28DH2	TATA box-binding protein-like protein 2	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00056	VEGF signaling pathway	P01417	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05730	Endogenous cannabinoid signaling	P05746	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04393	Ras Pathway	P04570	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00049	Parkinson disease	P01238	14-3-3	SCHMA|EnsemblGenome=Smp_009760|UniProtKB=G4LUI9	14-3-3 protein, putative	IDA	10407019	PubMed	PTHR18860:SF13	14-3-3 PROTEIN ZETA
P02775	Salvage pyrimidine ribonucleotides	P03152	Uridine phosphorylase	MACMU|Ensembl=ENSMMUG00000011636|UniProtKB=F6PIP9	Uridine phosphorylase	ISS			PTHR43691:SF8	URIDINE PHOSPHORYLASE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000010521|UniProtKB=F7DQK7	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00029	Huntington disease	P00811	Arp2/3 complex	HUMAN|HGNC=703|UniProtKB=Q92747	Actin-related protein 2/3 complex subunit 1A	TAS	12963527	gi	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00058	mRNA splicing	P01476	U4	CANLF|Ensembl=ENSCAFG00000011820|UniProtKB=E2R4I0	Uncharacterized protein	ISS	12875835	PubMed	PTHR14212:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3
P00030	Hypoxia response via HIF activation	P00819	AKT	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	TAS	21291563	gi	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01160	IP3 receptor	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	HUMAN|HGNC=16767|UniProtKB=Q8TCU5	Glutamate receptor ionotropic, NMDA 3A	ISS	11319238	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00005	Angiogenesis	P00214	HIF-1	CANLF|Ensembl=ENSCAFG00000015718|UniProtKB=F1PZ54	Uncharacterized protein	ISS	9606183	PubMed	PTHR23043:SF7	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA
P05730	Endogenous cannabinoid signaling	P05751	Galpha	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05730	Endogenous cannabinoid signaling	P05743	CB1	MONDO|Ensembl=ENSMODG00000018290|UniProtKB=F6T8W7	Uncharacterized protein	ISS	2165569	PubMed	PTHR22750:SF47	CANNABINOID RECEPTOR 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	HUMAN|HGNC=1951|UniProtKB=P08172	Muscarinic acetylcholine receptor M2	ISS	12181435	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	MOUSE|MGI=MGI=104634|UniProtKB=Q08122	Transducin-like enhancer protein 3	IDA	9783586	PubMed	PTHR10814:SF24	TRANSDUCIN-LIKE ENHANCER PROTEIN 3
P06959	CCKR signaling map	P07020	p110	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	RCA	10094466	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	10704417	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00029	Huntington disease	P00765	Hip-1	PANTR|Ensembl=ENSPTRG00000019307|UniProtKB=H2QUS3	Huntingtin interacting protein 1	ISS	9147654	PubMed	PTHR10407:SF14	HUNTINGTIN-INTERACTING PROTEIN 1
P00052	TGF-beta signaling pathway	P01284	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05935	AngII	MOUSE|MGI=MGI=87963|UniProtKB=P11859	Angiotensinogen	RCA			PTHR11461:SF13	ANGIOTENSINOGEN
P00053	T cell activation	P01335	jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	IC	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00009	Axon guidance mediated by netrin	P00366	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	15470041	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	SCHPO|PomBase=SPBC32H8.12c|UniProtKB=P10989	Actin	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00029	Huntington disease	P00805	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00005	Angiogenesis	P00212	EphR	MOUSE|MGI=MGI=99612|UniProtKB=P29319	Ephrin type-A receptor 3	ISS			PTHR24416:SF18	EPHRIN TYPE-A RECEPTOR 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CANLF|Gene=GNRHR|UniProtKB=Q9MZI6	Gonadotropin-releasing hormone receptor	ISS	1333052	PubMed	PTHR24241:SF22	GONADOTROPIN-RELEASING HORMONE RECEPTOR
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	188830	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	MONDO|Ensembl=ENSMODG00000019262|UniProtKB=F6Q8L1	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P04393	Ras Pathway	P04547	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	PANTR|Ensembl=ENSPTRG00000016100|UniProtKB=H2QPJ5	Uncharacterized protein	ISS	12629106	PubMed	PTHR24241:SF22	GONADOTROPIN-RELEASING HORMONE RECEPTOR
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	MACMU|Ensembl=ENSMMUG00000031224|UniProtKB=F7CKT2	Uncharacterized protein	ISS	10806215	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00047	PDGF signaling pathway	P01142	p90RSK	XENTR|Xenbase=XB-GENE-480947|UniProtKB=F6ZM17	Uncharacterized protein (Fragment)	ISS	2779569	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04558	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P05731	GABA-B receptor II signaling	P05754	Ggamma	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00025	Hedgehog signaling pathway	P00682	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00790	beta-Tubulin	MACMU|Ensembl=ENSMMUG00000023785|UniProtKB=F7HTD6	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P04395	Vasopressin synthesis	P04590	Vasopressin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00010	B cell activation	P00373	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	TAS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00018	EGF receptor signaling pathway	P00551	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00359	NFAT	MACMU|Ensembl=ENSMMUG00000012657|UniProtKB=F7E7J1	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00057	Wnt signaling pathway	P01444	Wnt	RAT|RGD=1307644|UniProtKB=D3ZND6	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00010	B cell activation	P00367	NFAT	HUMAN|HGNC=7775|UniProtKB=O95644	Nuclear factor of activated T-cells, cytoplasmic 1	IDA	9133421	PubMed	PTHR12533:SF5	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	ISS	12719720	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P02738	De novo purine biosynthesis	P02889	dGDP kinase	RAT|RGD=70497|UniProtKB=Q05982	Nucleoside diphosphate kinase A	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	DROME|FlyBase=FBgn0024909|UniProtKB=Q9VHY5	Transcription initiation factor TFIID subunit 7	ISS			PTHR12228:SF0	TAF7 RNA POLYMERASE II, TATA BOX BINDING PROTEIN  TBP -ASSOCIATED FACTOR
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	ARATH|TAIR=AT3G43810|UniProtKB=P59220	Calmodulin-7	ISS	9753452	PubMed	PTHR23050:SF250	CALMODULIN-7
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	DANRE|ZFIN=ZDB-GENE-010705-1|UniProtKB=Q90Z40	Guanine nucleotide-binding protein subunit gamma	IDA			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00010	B cell activation	P00369	MEKK	BOVIN|Ensembl=ENSBTAG00000008151|UniProtKB=F1MH06	Uncharacterized protein	ISS	8649450	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04563	Ets	BOVIN|Ensembl=ENSBTAG00000002341|UniProtKB=A5PJG9	ETS1 protein	ISS	15298723	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00778	NMDA receptor	MOUSE|MGI=MGI=95821|UniProtKB=Q01097	Glutamate receptor ionotropic, NMDA 2B	IDA	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00010	B cell activation	P00371	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IDA	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05918	p38 MAPK pathway	P06029	p38beta	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00047	PDGF signaling pathway	P01153	GSK3	PANTR|Ensembl=ENSPTRG00000011049|UniProtKB=H2QGF9	Glycogen synthase kinase 3 alpha	ISS	14698990	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00048	PI3 kinase pathway	P01192	p110	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00059	p53 pathway	G01579	PTEN	DANRE|ZFIN=ZDB-GENE-030131-3776|UniProtKB=E7FC59	Uncharacterized protein	ISS			PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00005	Angiogenesis	P00254	GTPase	CHICK|Ensembl=ENSGALG00000001569|UniProtKB=Q9PSX7	Rho-related GTP-binding protein RhoC	ISS	14871999	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P04393	Ras Pathway	P04572	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00007	Axon guidance mediated by semaphorins	P00340	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00056	VEGF signaling pathway	P01407	Erk	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02746	Heme biosynthesis	P02982	Protoheme IX farnesyl transferase	BACSU|EnsemblGenome=BSU12080|UniProtKB=O31652	Protoheme IX farnesyltransferase 1	ISS			PTHR43448:SF1	PROTOHEME IX FARNESYLTRANSFERASE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00018	EGF receptor signaling pathway	P00562	p38	DROME|FlyBase=FBgn0015765|UniProtKB=O62618	Mitogen-activated protein kinase 14A	IGI	11707292	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P04398	p53 pathway feedback loops 2	P04651	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	RAT|RGD=2026|UniProtKB=P68035	Actin, alpha cardiac muscle 1	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00005	Angiogenesis	P00243	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00922	Collagen	RAT|RGD=2373|UniProtKB=F6T0B3	Procollagen, type XI, alpha 2 (Mapped)	ISS	10778855	PubMed	PTHR24023:SF509	COLLAGEN ALPHA-2 XI  CHAIN
P00029	Huntington disease	P00807	Actin	TAKRU|Ensembl=ENSTRUG00000014318|UniProtKB=H2UI49	Uncharacterized protein	IDA	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00038	JAK/STAT signaling pathway	P01031	PIAS	MONDO|Ensembl=ENSMODG00000003324|UniProtKB=F7DDM9	Uncharacterized protein	ISS	8682149	PubMed	PTHR10782:SF12	E3 SUMO-PROTEIN LIGASE PIAS2
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00006	Apoptosis signaling pathway	P00269	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P06664	Gonadotropin-releasing hormone receptor pathway	P06795	STAT3	MOUSE|MGI=MGI=103038|UniProtKB=P42227	Signal transducer and activator of transcription 3	RCA	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00005	Angiogenesis	P00211	GSK3beta	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00049	Parkinson disease	P01208	Hsp70	GIAIC|EnsemblGenome=GL50803_88765|UniProtKB=A8BCR6	Cytosolic HSP70	IDA	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P06664	Gonadotropin-releasing hormone receptor pathway	P06795	STAT3	MOUSE|MGI=MGI=103038|UniProtKB=P42227	Signal transducer and activator of transcription 3	RCA	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00036	Interleukin signaling pathway	P00970	Interleukin	RAT|RGD=1583872|UniProtKB=D4A4I9	Interleukin 16 (Mapped)	ISS			PTHR11324:SF2	PRO-INTERLEUKIN-16
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00048	PI3 kinase pathway	P01179	PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00236	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	RAT|RGD=620838|UniProtKB=Q8VHK6	Interleukin-13 receptor subunit alpha-2	ISS	12241113	PubMed	PTHR23036:SF101	INTERLEUKIN-13 RECEPTOR SUBUNIT ALPHA-2
P02775	Salvage pyrimidine ribonucleotides	P03150	Uridine kinase	HUMAN|HGNC=12562|UniProtKB=Q9BZX2	Uridine-cytidine kinase 2	ISS			PTHR10285:SF70	URIDINE-CYTIDINE KINASE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00054	Toll receptor signaling pathway	P01354	NFkappaB	CANLF|Ensembl=ENSCAFG00000013334|UniProtKB=F1PCU1	Uncharacterized protein	ISS	10049353	PubMed	PTHR24169:SF1	TRANSCRIPTION FACTOR P65
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00005	Angiogenesis	P00226	Delta/Serrate	RAT|RGD=1309740|UniProtKB=D3ZHH1	Delta-like protein 4	ISS	11798067	PubMed	PTHR24044:SF320	DELTA-LIKE PROTEIN 4
P02781	Threonine biosynthesis	P03192	Aspartate semialdehyde dehydrogenase	DEIRA|EnsemblGenome=DR_2008|UniProtKB=Q9RSW3	Aspartate-semialdehyde dehydrogenase	ISS			PTHR10174:SF2	ASPARTATE-SEMIALDEHYDE DEHYDROGENASE
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MOUSE|MGI=MGI=95819|UniProtKB=P35438	Glutamate receptor ionotropic, NMDA 1	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00015	Circadian clock system	P00502	Casein kinase I	XENTR|Xenbase=XB-GENE-5733929|UniProtKB=Q6P647	Casein kinase I isoform delta	ISS	10617630	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P05916	Opioid prodynorphin pathway	P06002	G-protein	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	HUMAN|HGNC=409|UniProtKB=P47895	Aldehyde dehydrogenase family 1 member A3	IC			PTHR11699:SF209	ALDEHYDE DEHYDROGENASE FAMILY 1 MEMBER A3
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04397	p53 pathway by glucose deprivation	P04641	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02746	Heme biosynthesis	P02979	porphobilinogen synthase	CHLRE|EnsemblGenome=CHLREDRAFT_186639|UniProtKB=A8I980	Delta-aminolevulinic acid dehydratase	ISS			PTHR11458:SF0	DELTA-AMINOLEVULINIC ACID DEHYDRATASE
P00020	FAS signaling pathway	P00610	MKK4	HUMAN|HGNC=6844|UniProtKB=P45985	Dual specificity mitogen-activated protein kinase kinase 4	TAS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_114535|UniProtKB=C3ZHN2	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00570	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01160	IP3 receptor	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04398	p53 pathway feedback loops 2	P04651	Ras	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	IDA	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00060	Ubiquitin proteasome pathway	P01491	E2	ORYSJ|EnsemblGenome=OS07G0166800|UniProtKB=Q7XIC8	Os07g0166800 protein	ISS			PTHR43898:SF2	SUBFAMILY NOT NAMED
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	SCHMA|EnsemblGenome=Smp_059340|UniProtKB=C4QDC7	Guanine nucleotide-binding protein G(S) subunit alpha (Adenylate cyclase-stimulating G alpha protein),putative	ISS			PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00036	Interleukin signaling pathway	P00973	PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P06959	CCKR signaling map	P07216	PRKD2	HUMAN|HGNC=17293|UniProtKB=Q9BZL6	Serine/threonine-protein kinase D2	RCA	17962809	PubMed	PTHR22968:SF12	SERINE/THREONINE-PROTEIN KINASE D2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	RAT|RGD=2738|UniProtKB=Q00960	Glutamate receptor ionotropic, NMDA 2B	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	XENTR|Xenbase=XB-GENE-976753|UniProtKB=Q0VFR6	Syntaxin 1A (Brain)	ISS	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P02755	Methylmalonyl pathway	P03034	Methylmalonyl-CoA mutase	HALSA|EnsemblGenome=VNG_0481G|UniProtKB=Q9HRZ1	Methylmalonyl-CoA mutase, subunit alpha	ISS			PTHR43589:SF2	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	PANTR|Ensembl=ENSPTRG00000002849|UniProtKB=H2Q2F4	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00054	Toll receptor signaling pathway	P01367	MKK3	BOVIN|Ensembl=ENSBTAG00000010576|UniProtKB=A4IFH7	MAP2K3 protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00005	Angiogenesis	P00203	Erk	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00211	GSK3beta	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IDA	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00047	PDGF signaling pathway	P01148	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12748278	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	BOVIN|Ensembl=ENSBTAG00000015670|UniProtKB=E1B7J7	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00034	Integrin signalling pathway	P00920	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05912	Dopamine receptor mediated signaling pathway	P05950	DARPP-32	BOVIN|Ensembl=ENSBTAG00000006035|UniProtKB=P07516	Protein phosphatase 1 regulatory subunit 1B	ISS	3339428	PubMed	PTHR15417:SF2	PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 1B
P00049	Parkinson disease	P01236	Casein kinase II	RAT|RGD=619978|UniProtKB=P67874	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	CANLF|Ensembl=ENSCAFG00000015856|UniProtKB=J9P3S5	Nucleoside diphosphate kinase	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DROME|FlyBase=FBgn0000043|UniProtKB=P02572	Actin-42A	ISS	11889126	PubMed	PTHR11937:SF369	ACTIN-42A
P00049	Parkinson disease	P01227	20S proteasome	XENTR|Xenbase=XB-GENE-976787|UniProtKB=F6XZS3	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF10	PROTEASOME SUBUNIT ALPHA TYPE-3
P00054	Toll receptor signaling pathway	P01370	TAK1	CANLF|Ensembl=ENSCAFG00000003123|UniProtKB=E2R3R6	Uncharacterized protein	ISS	10683140	PubMed	PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P04393	Ras Pathway	P04572	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00547	PP2A	SCHPO|PomBase=SPCC188.02|UniProtKB=Q10428	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta 1 isoform	ISS	10092233	PubMed	PTHR10257:SF3	PP2A-B', ISOFORM B
P02772	Pyruvate metabolism	P03136	Malic enzyme	GIAIC|EnsemblGenome=GL50803_14285|UniProtKB=A8BE38	Malic enzyme	NAS	1666243	gi	PTHR23406:SF32	NAD-DEPENDENT MALIC ENZYME 2, MITOCHONDRIAL
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00005	Angiogenesis	P00187	beta catenin	MOUSE|MGI=MGI=88276|UniProtKB=Q02248	Catenin beta-1	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00015	Circadian clock system	P00505	Cry	CANLF|Ensembl=ENSCAFG00000001797|UniProtKB=E2RMX4	Uncharacterized protein	ISS	10217146	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	SULSO|EnsemblGenome=SSO2216|UniProtKB=Q97WK0	Acetyl-CoA synthetase (Acetate-CoA ligase) (AcsA-8)	ISS			PTHR24095:SF232	SUBFAMILY NOT NAMED
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	CAEEL|WormBase=WBGene00002173|UniProtKB=Q9Y0A1	Inositol 1,4,5-trisphosphate receptor itr-1	ISS	9065779	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00011	Blood coagulation	P00416	Prothrombin	CHICK|Ensembl=ENSGALG00000008332|UniProtKB=F1NXV6	Prothrombin	ISS	289825	gi	PTHR24254:SF10	PROTHROMBIN
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	MOUSE|MGI=MGI=1351344|UniProtKB=Q68ED2	Metabotropic glutamate receptor 7	ISS	12351712	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00034	Integrin signalling pathway	P00944	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g242065|UniProtKB=A7S0V7	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	P01438	PP2A	MOUSE|MGI=MGI=1349473|UniProtKB=Q61151	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	ISS	8703017	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00005	Angiogenesis	P00206	Wnt	TAKRU|Ensembl=ENSTRUG00000016522|UniProtKB=H2UZ46	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	HUMAN|HGNC=4597|UniProtKB=P41594	Metabotropic glutamate receptor 5	ISS	92317054	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00029	Huntington disease	P00786	ARF	SCHPO|PomBase=SPBC4F6.18c|UniProtKB=P36579	ADP-ribosylation factor 1	IPI	11752622	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00018	EGF receptor signaling pathway	P00557	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	14505573	PubMed	PTHR10048:SF14	PI-3 KINASE
P00052	TGF-beta signaling pathway	P01284	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00059	p53 pathway	G04694	p110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01444	Wnt	DANRE|ZFIN=ZDB-GENE-081003-1|UniProtKB=B0LK22	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P04393	Ras Pathway	P04543	MEKK1/4	RAT|RGD=1311192|UniProtKB=A0A0G2K3R1	Protein Map3k4	ISS	97236778	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00052	TGF-beta signaling pathway	P01286	TGFbeta	HUMAN|HGNC=6068|UniProtKB=P55103	Inhibin beta C chain	TAS	9759503	PubMed	PTHR11848:SF130	INHIBIN BETA C CHAIN
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	HUMAN|HGNC=2092|UniProtKB=Q00610	Clathrin heavy chain 1	IDA	9388255	PubMed	PTHR10292:SF7	CLATHRIN HEAVY CHAIN 1
P00018	EGF receptor signaling pathway	P00552	Ras	BOVIN|Ensembl=ENSBTAG00000009778|UniProtKB=E1BMX0	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00047	PDGF signaling pathway	P01172	c-Myc	CANLF|Gene=MYC|UniProtKB=Q28350	Myc proto-oncogene protein	ISS	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	HUMAN|HGNC=7881|UniProtKB=P46531	Neurogenic locus notch homolog protein 1	IDA	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	P01438	PP2A	ORNAN|Ensembl=ENSOANG00000008492|UniProtKB=F6XL57	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00219	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	90172230	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	BOVIN|Ensembl=ENSBTAG00000014828|UniProtKB=F1N1E0	Uncharacterized protein	ISS	14624853	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00048	PI3 kinase pathway	P01206	14-3-3	MONDO|Ensembl=ENSMODG00000006158|UniProtKB=F7BS95	Uncharacterized protein	ISS	92283271	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P04398	p53 pathway feedback loops 2	P04665	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00645	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00054	Toll receptor signaling pathway	P01344	TRIF	PANTR|Ensembl=ENSPTRG00000010322|UniProtKB=H2R6G6	Uncharacterized protein	ISS	22359180	PubMed	PTHR23213:SF331	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00047	PDGF signaling pathway	P01160	IP3 receptor	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00005	Angiogenesis	P00193	SOS-1	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	IC	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	RAT|RGD=2743|UniProtKB=P31421	Metabotropic glutamate receptor 2	ISS	9407094	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00010	B cell activation	P00371	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CHICK|Ensembl=ENSGALG00000014539|UniProtKB=F1N861	Uncharacterized protein	ISS	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000023202|UniProtKB=F7EU36	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05913	Enkephalin release	P05972	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	15313841	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	MACMU|Ensembl=ENSMMUG00000021752|UniProtKB=H9H490	C-C motif chemokine	ISS			PTHR12015:SF91	C-C MOTIF CHEMOKINE 3-RELATED
P00018	EGF receptor signaling pathway	P00543	ERK1-2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05939	GRK6	BOVIN|Ensembl=ENSBTAG00000043994|UniProtKB=E1BP29	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00025	Hedgehog signaling pathway	P00690	Cubitus interruptus	MOUSE|MGI=MGI=95727|UniProtKB=P47806	Zinc finger protein GLI1	IDA			PTHR19818:SF2	ZINC FINGER PROTEIN GLI1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	RAT|RGD=2735|UniProtKB=Q63273	Glutamate receptor ionotropic, kainate 5	ISS	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	IC	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	STRCO|Gene=CAB97431|UniProtKB=Q9K3J2	Betaine aldehyde dehydrogenase	ISS			PTHR43860:SF2	BETAINE ALDEHYDE DEHYDROGENASE 1, CHLOROPLASTIC-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2522|UniProtKB=P30729	D(4) dopamine receptor	IDA	2039532	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	BOVIN|Ensembl=ENSBTAG00000005835|UniProtKB=Q17QJ7	Pyrroline-5-carboxylate reductase 2	ISS			PTHR11645:SF4	PYRROLINE-5-CARBOXYLATE REDUCTASE 2
P00056	VEGF signaling pathway	P01408	Akt/PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00056	VEGF signaling pathway	P01417	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00819	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01428	Frizzled	BOVIN|Ensembl=ENSBTAG00000010529|UniProtKB=F1MP23	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF75	FRIZZLED-6
P05730	Endogenous cannabinoid signaling	P05751	Galpha	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05915	Opioid proenkephalin pathway	P05994	G-protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	CANLF|Ensembl=ENSCAFG00000005526|UniProtKB=E2RKR0	Uncharacterized protein	ISS	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	G01550	Gene trancription	BOVIN|Gene=PTGS2|UniProtKB=O62698	Prostaglandin G/H synthase 2	ISS	21141972	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P04384	Gamma-aminobutyric acid synthesis	P04482	Glutamate decarboxylase	ORNAN|Ensembl=ENSOANG00000006028|UniProtKB=F6V5H0	Uncharacterized protein	ISS	2247446	PubMed	PTHR11999:SF77	GLUTAMATE DECARBOXYLASE 2
P05913	Enkephalin release	P05972	PKA	LEIMA|EnsemblGenome=LmjF.35.4010|UniProtKB=Q9GNR4	Protein kinase A catalytic subunit isoform 1	ISS	14744463	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00942	Fyn	TAKRU|Ensembl=ENSTRUG00000014739|UniProtKB=H2UL58	Tyrosine-protein kinase	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	DROME|FlyBase=FBgn0004611|UniProtKB=P25455	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II	ISS	1707501	PubMed	PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00006	Apoptosis signaling pathway	P00260	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00053	T cell activation	P01307	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05938	RhoA	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CAEBR|Gene=CBG02162|UniProtKB=A8WS33	Protein CBG02162	ISS	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	CHICK|Ensembl=ENSGALG00000009320|UniProtKB=Q4JIM4	Presenilin-1	IDA	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00859	NFkappaB	MOUSE|MGI=MGI=103289|UniProtKB=Q04863	Transcription factor RelB	IDA	12505990	PubMed	PTHR24169:SF18	TRANSCRIPTION FACTOR RELB
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	DANRE|ZFIN=ZDB-GENE-030616-53|UniProtKB=Q71E60	AMPA receptor subunit GluR3B	ISS	12871085	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P05731	GABA-B receptor II signaling	P05755	Gbeta	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00019	Endothelin signaling pathway	P00591	PLCbeta	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00010	B cell activation	P00373	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IGI	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01456	beta-arrestin	MACMU|Ensembl=ENSMMUG00000017654|UniProtKB=F6UI32	Beta-arrestin-2 isoform 1	ISS	12464600	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00029	Huntington disease	P00774	Dynein complex	MOUSE|MGI=MGI=107718|UniProtKB=Q8VHE6	Dynein heavy chain 5, axonemal	IPI	9454836	PubMed	PTHR10676:SF240	DYNEIN HEAVY CHAIN 5, AXONEMAL
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IGI	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05913	Enkephalin release	P05973	GPCR (i)	MACMU|Ensembl=ENSMMUG00000009389|UniProtKB=F7HEV7	Uncharacterized protein	ISS	11259487	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	BOVIN|Ensembl=ENSBTAG00000004775|UniProtKB=F1MBY1	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05918	p38 MAPK pathway	P06025	SRF	CANLF|Ensembl=ENSCAFG00000001829|UniProtKB=F1PH12	Uncharacterized protein	ISS	8660892	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P05731	GABA-B receptor II signaling	P05754	Ggamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	RCA	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	CHICK|Gene=CHRNB3|UniProtKB=P43679	Neuronal acetylcholine receptor subunit beta-3	ISS			PTHR18945:SF75	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-3
P00036	Interleukin signaling pathway	P00973	PKB	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	HUMAN|HGNC=8569|UniProtKB=P29122	Proprotein convertase subtilisin/kexin type 6	IDA			PTHR42884:SF8	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 6
P00006	Apoptosis signaling pathway	P00258	Bik	PANTR|Ensembl=ENSPTRG00000014467|UniProtKB=H2QLU7	Uncharacterized protein	ISS	11884414	PubMed	PTHR15018:SF1	BCL-2-INTERACTING KILLER
P04397	p53 pathway by glucose deprivation	P04636	S6K	CHICK|Ensembl=ENSGALG00000005198|UniProtKB=F1P4J0	Ribosomal protein S6 kinase	IDA	11861821	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00047	PDGF signaling pathway	P01171	PLCgamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	MOUSE|MGI=MGI=95794|UniProtKB=A2ARV4	Low-density lipoprotein receptor-related protein 2	ISS	11907044	PubMed	PTHR44025:SF5	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2
P00060	Ubiquitin proteasome pathway	P01490	E3	MOUSE|MGI=MGI=1202301|UniProtKB=Q8C863	E3 ubiquitin-protein ligase Itchy	ISS			PTHR11254:SF66	E3 UBIQUITIN-PROTEIN LIGASE ITCHY HOMOLOG
P00052	TGF-beta signaling pathway	P01286	TGFbeta	TAKRU|Ensembl=ENSTRUG00000018458|UniProtKB=H2VDF6	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF230	GDF11-LIKE
P00047	PDGF signaling pathway	P01162	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00049	Parkinson disease	P01236	Casein kinase II	PHYPA|Gene=PHYPADRAFT_183198|UniProtKB=A9SBU0	Predicted protein	ISS	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	DROME|FlyBase=FBgn0011300|UniProtKB=A1Z7L8	Receptor protein serine/threonine kinase	TAS	10683140	PubMed	PTHR23255:SF71	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00060	Ubiquitin proteasome pathway	P01492	E1	CANLF|Ensembl=ENSCAFG00000005018|UniProtKB=F1PI66	Uncharacterized protein	ISS			PTHR10953:SF3	UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7
P00014	Cholesterol biosynthesis	P00496	Diphosphomevalonate decarboxylase	SCHPO|PomBase=SPAC24C9.03|UniProtKB=O13963	Diphosphomevalonate decarboxylase	ISS	4505289	gi	PTHR10977:SF3	DIPHOSPHOMEVALONATE DECARBOXYLASE
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	CANLF|Ensembl=ENSCAFG00000010787|UniProtKB=E2R3W6	Uncharacterized protein	ISS	11861492	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00019	Endothelin signaling pathway	P00566	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	ASHGO|EnsemblGenome=AGOS_AGL093W|UniProtKB=Q9HF56	Cell division control protein 42	ISS			PTHR24072:SF192	CDC42 HOMOLOG
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ENTHI|EnsemblGenome=EHI_107290|UniProtKB=B1N2P0	Actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	YEAST|SGD=S000005738|UniProtKB=P18851	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MOUSE|MGI=MGI=95822|UniProtKB=Q01098	Glutamate receptor ionotropic, NMDA 2C	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IC	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	MACMU|Ensembl=ENSMMUG00000020819|UniProtKB=F7HSM1	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	IC	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00054	Toll receptor signaling pathway	P01352	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02728	Arginine biosynthesis	P02846	Ornithine carbamoyl transferase	METAC|EnsemblGenome=MA_3310|UniProtKB=Q8TKT5	Ornithine carbamoyltransferase	ISS			PTHR11405:SF1	ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IGI	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00049	Parkinson disease	P01211	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	IDA	12471242	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	PANTR|Ensembl=ENSPTRG00000003699|UniProtKB=H2Q3R5	Syntaxin 3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00049	Parkinson disease	P01224	UbcH7	MACMU|Ensembl=ENSMMUG00000008940|UniProtKB=F7EVY1	Uncharacterized protein	ISS	10888878	PubMed	PTHR24068:SF67	UBIQUITIN-CONJUGATING ENZYME E2 L3
P00018	EGF receptor signaling pathway	P00558	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01182	Ras	CAEEL|WormBase=WBGene00002335|UniProtKB=P22981	Ras protein let-60	ISS	12024031	PubMed	PTHR24070:SF385	GTPASE HRAS
P05730	Endogenous cannabinoid signaling	P05751	Galpha	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01167	Ets	PANTR|Ensembl=ENSPTRG00000013810|UniProtKB=H2R0L6	GA binding protein transcription factor, alpha subunit 60kDa	ISS	15298723	PubMed	PTHR11849:SF195	GA-BINDING PROTEIN ALPHA CHAIN
P00036	Interleukin signaling pathway	P00994	FKHRL1	BOVIN|Ensembl=ENSBTAG00000011234|UniProtKB=F1N4K5	Uncharacterized protein	ISS	10102273	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	ISS	1319556	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01135	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	TAS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IC	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05918	p38 MAPK pathway	P05920	MAPKAP-K2	MACMU|Ensembl=ENSMMUG00000023567|UniProtKB=F7HHY8	Uncharacterized protein	ISS	9628873	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DICDI|dictyBase=DDB_G0289811|UniProtKB=Q54GX7	Actin-10	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00053	T cell activation	P01300	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MACMU|Ensembl=ENSMMUG00000017431|UniProtKB=F7HPP3	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00018	EGF receptor signaling pathway	P00551	Akt	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	IGI	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04651	Ras	CAEBR|Gene=CBG06092|UniProtKB=A8X0X5	Protein CBR-LET-60	ISS	12024031	PubMed	PTHR24070:SF385	GTPASE HRAS
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00054	Toll receptor signaling pathway	P01375	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P06587	Nicotine pharmacodynamics pathway	P06589	PPP1R1B	MOUSE|MGI=MGI=94860|UniProtKB=Q60829	Protein phosphatase 1 regulatory subunit 1B	RCA	3339428	PubMed	PTHR15417:SF2	PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 1B
P00019	Endothelin signaling pathway	P00586	Gq	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00019	Endothelin signaling pathway	P00590	IP3 R	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	IGI	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	BRAFL|Gene=BRAFLDRAFT_128184|UniProtKB=C4A0B6	Tyrosine-protein kinase receptor	ISS	249616	gi	PTHR24416:SF402	INSULIN RECEPTOR
P02775	Salvage pyrimidine ribonucleotides	P03149	Cytidine kinase	MACMU|Ensembl=ENSMMUG00000000565|UniProtKB=F6ZWL3	Uridine-cytidine kinase	ISS			PTHR10285:SF70	URIDINE-CYTIDINE KINASE 2
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	ORYSJ|EnsemblGenome=OS04G0659100|UniProtKB=P14655	Glutamine synthetase, chloroplastic	ISS			PTHR20852:SF53	GLUTAMINE SYNTHETASE, CHLOROPLASTIC/MITOCHONDRIAL
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00010	B cell activation	P00383	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05915	Opioid proenkephalin pathway	P05988	peptide E	MOUSE|MGI=MGI=104629|UniProtKB=P22005	Proenkephalin-A	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000023940|UniProtKB=F6RFW8	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	CAEEL|WormBase=WBGene00000295|UniProtKB=Q9GNP0	Uncharacterized protein	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00037	Ionotropic glutamate receptor pathway	P01021	Vglut	MOUSE|MGI=MGI=2156052|UniProtKB=Q8BLE7	Vesicular glutamate transporter 2	ISS	12815758	PubMed	PTHR11662:SF201	VESICULAR GLUTAMATE TRANSPORTER 2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P06212	DPP-SCW signaling pathway	P06263	FUR1	DROME|FlyBase=FBgn0004509|UniProtKB=P26016	Furin-like protease 1, isoforms 1/1-X/2	IEA	7737999	PubMed	PTHR42884:SF3	FURIN-LIKE PROTEASE 1, ISOFORMS 1/1-X/2
P00053	T cell activation	P01300	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00398	IP3R	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	IGI	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00047	PDGF signaling pathway	P01152	RasGAP	DROME|FlyBase=FBgn0003969|UniProtKB=Q8IR23	GH13542p	ISS	7293174	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	RCA	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00623	FGF	RAT|RGD=620163|UniProtKB=P61150	Fibroblast growth factor 12	ISS	9232594	PubMed	PTHR11486:SF17	FIBROBLAST GROWTH FACTOR 12
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00021	FGF signaling pathway	P00629	PP2A	SCHPO|PomBase=SPAC823.15|UniProtKB=P23635	Minor serine/threonine-protein phosphatase PP2A-1 catalytic subunit	ISS			PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00187	beta catenin	RAT|RGD=70487|UniProtKB=Q9WU82	Catenin beta-1	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00010	B cell activation	P00379	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05731	GABA-B receptor II signaling	P05755	Gbeta	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_115291|UniProtKB=C3ZMR2	Putative uncharacterized protein	ISS			PTHR11937:SF359	SUBFAMILY NOT NAMED
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=98955|UniProtKB=P17553	Proto-oncogene Wnt-3	IDA	8717036	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000015640|UniProtKB=E2QVF3	Uncharacterized protein	ISS	8444355	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	TAS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00012	Cadherin signaling pathway	P00474	Wnt	PANTR|Ensembl=ENSPTRG00000002064|UniProtKB=H2R817	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P05916	Opioid prodynorphin pathway	P05997	prodynorphin	PANTR|Ensembl=ENSPTRG00000013172|UniProtKB=H2QJT9	Uncharacterized protein	ISS	131330	OMIM	PTHR11438:SF4	PROENKEPHALIN-B
P00019	Endothelin signaling pathway	P00586	Gq	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00051	TCA cycle	P01267	Citrate Synthase	ECOLI|EcoGene=EG10402|UniProtKB=P0ABH7	Citrate synthase	ISS	11258796	PubMed	PTHR42871:SF1	CITRATE SYNTHASE
P00053	T cell activation	P01311	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00013	Cell cycle	P00480	Proteasome	BOVIN|Gene=PSMD13|UniProtKB=Q5E964	26S proteasome non-ATPase regulatory subunit 13	ISS	10225435	PubMed	PTHR10539:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	HUMAN|HGNC=6091|UniProtKB=P06213	Insulin receptor	ISS	14500580	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P00029	Huntington disease	P00805	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00240	FRS-2	HUMAN|HGNC=16971|UniProtKB=Q8WU20	Fibroblast growth factor receptor substrate 2	IDA	10464310	PubMed	PTHR21258:SF40	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2
P00057	Wnt signaling pathway	P01444	Wnt	MONDO|Ensembl=ENSMODG00000018415|UniProtKB=F6XUZ7	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Ensembl=ENSBTAG00000037726|UniProtKB=P10895	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	12860966	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00006	Apoptosis signaling pathway	P00303	c-Jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00049	Parkinson disease	P01227	20S proteasome	XENTR|Xenbase=XB-GENE-964711|UniProtKB=F6YDY3	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF16	PROTEASOME SUBUNIT ALPHA TYPE-2
P00048	PI3 kinase pathway	P01192	p110	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	G04702	p53	CHICK|Ensembl=ENSGALG00000007324|UniProtKB=F1N8Z7	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00030	Hypoxia response via HIF activation	P00824	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00029	Huntington disease	P00807	Actin	MACMU|Ensembl=ENSMMUG00000012054|UniProtKB=F6TII3	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00053	T cell activation	P01336	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	IC	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	ARATH|TAIR=AT5G58690|UniProtKB=Q944C2	Phosphoinositide phospholipase C 5	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00048	PI3 kinase pathway	P01199	Galpha	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	CHICK|Ensembl=ENSGALG00000003820|UniProtKB=E1C8Y3	Actin-related protein 2/3 complex subunit 3	ISS	9359840	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00010	B cell activation	P00379	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IDA	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010034|UniProtKB=F1PEE8	Uncharacterized protein	ISS	15858232	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00029	Huntington disease	P00805	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00187	beta catenin	BOVIN|Ensembl=ENSBTAG00000016420|UniProtKB=Q0VCX4	Catenin beta-1	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	PANTR|Ensembl=ENSPTRG00000013244|UniProtKB=H2QJY6	Uncharacterized protein	ISS			PTHR24361:SF183	SERINE/THREONINE-PROTEIN KINASE PAK 7
P02723	Adenine and hypoxanthine salvage pathway	P02804	Hypoxanthine phosphoribosyl transferase	ORNAN|Ensembl=ENSOANG00000011689|UniProtKB=F7AT83	Uncharacterized protein	ISS			PTHR43340:SF6	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE
P04393	Ras Pathway	P04552	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00021	FGF signaling pathway	P00629	PP2A	HUMAN|HGNC=9306|UniProtKB=Q9Y2T4	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform	ISS	12191994	PubMed	PTHR11871:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B GAMMA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P06664	Gonadotropin-releasing hormone receptor pathway	P06831	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	RCA	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	BOVIN|Ensembl=ENSBTAG00000047719|UniProtKB=Q95136	D(1A) dopamine receptor	ISS	11861492	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00011	Blood coagulation	P00416	Prothrombin	PANTR|Ensembl=ENSPTRG00000003552|UniProtKB=H2Q3I2	Prothrombin	ISS	+176930	OMIM	PTHR24254:SF10	PROTHROMBIN
P04398	p53 pathway feedback loops 2	P04664	cyclin E	RAT|RGD=2294|UniProtKB=P39949	G1/S-specific cyclin-E1	NAS	15705141	gi	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01443	Phospholipase C	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	XENTR|Xenbase=XB-GENE-957124|UniProtKB=F7BDN8	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	2837282	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	SYNY3|EnsemblGenome=BAA17055|UniProtKB=P77961	Glutamine synthetase	ISS			PTHR43407:SF1	LENGSIN
P05913	Enkephalin release	P05974	G-Protein (i)	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00047	PDGF signaling pathway	P01153	GSK3	ARATH|TAIR=AT5G26751|UniProtKB=P43288	Shaggy-related protein kinase alpha	ISS	21361340	gi	PTHR24057:SF13	SHAGGY-RELATED PROTEIN KINASE ALPHA-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	ANOGA|EnsemblGenome=AGAP002578|UniProtKB=F5HKU8	AGAP002578-PB	ISS	14507926	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000007084|UniProtKB=H2Q9G5	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	ORNAN|Ensembl=ENSOANG00000007732|UniProtKB=F6PXH5	Uncharacterized protein (Fragment)	ISS	11971971	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00005	Angiogenesis	P00233	CSL	PANTR|Ensembl=ENSPTRG00000015968|UniProtKB=H2R2Q6	Uncharacterized protein	ISS	15187023	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00004	Alzheimer disease-presenilin pathway	P00115	Nicastrin	MACMU|Ensembl=ENSMMUG00000021856|UniProtKB=F7EHX8	Nicastrin	ISS	10993067	PubMed	PTHR21092:SF0	NICASTRIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IDA	176910	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=98962|UniProtKB=P28047	Protein Wnt-7b	TAS	11266476	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00057	Wnt signaling pathway	P01444	Wnt	RAT|RGD=1597195|UniProtKB=D4A9J2	Protein Wnt	ISS	14644163	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MACMU|Ensembl=ENSMMUG00000016428|UniProtKB=F7GU00	Metabotropic glutamate receptor 1 isoform alpha	ISS	12488551	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DICDI|dictyBase=DDB_G0286555|UniProtKB=P34147	Rho-related protein racA	ISS	12932731	PubMed	PTHR24072:SF183	RHO-RELATED PROTEIN RACA
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	MONDO|Ensembl=ENSMODG00000015696|UniProtKB=F7E0Q7	Fructose-bisphosphate aldolase	ISS	4812352	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00018	EGF receptor signaling pathway	P00561	STAT	MACMU|Ensembl=ENSMMUG00000010705|UniProtKB=F7G8V4	Signal transducer and activator of transcription	ISS	10835485	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PUCGT|EnsemblGenome=PGTG_05488|UniProtKB=E3K4I1	Actin	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	RAT|RGD=1303097|UniProtKB=Q4KMC4	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2	ISS			PTHR10937:SF10	GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE  ISOMERIZING  2
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00056	VEGF signaling pathway	P01411	Ras	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	ISS	22097630	PubMed	PTHR24070:SF189	GTPASE NRAS
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	RAT|RGD=1309329|UniProtKB=F1MAD0	Protein Lrp5	ISS	11029006	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MONDO|Ensembl=ENSMODG00000000771|UniProtKB=F6SSS3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00029	Huntington disease	P00778	NMDA receptor	CANLF|Gene=GRIN1|UniProtKB=Q5R1P0	Glutamate receptor ionotropic, NMDA 1	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IC	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	10891487	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00018	EGF receptor signaling pathway	P00557	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00562	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	ISS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=1928330|UniProtKB=Q6PFX6	Cadherin-24	ISS	8120095	PubMed	PTHR24027:SF272	CADHERIN-24
P00059	p53 pathway	P04633	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-478663|UniProtKB=F7EG64	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IGI	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00777	CBP	CAEEL|WormBase=WBGene00009595|UniProtKB=Q7JMS5	Uncharacterized protein	IDA	10664585	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	MACMU|Ensembl=ENSMMUG00000014498|UniProtKB=F7GEI8	Uncharacterized protein	ISS	14624853	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Ensembl=ENSBTAG00000013632|UniProtKB=E1B965	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P06959	CCKR signaling map	G06998	COX2	HUMAN|HGNC=9605|UniProtKB=P35354	Prostaglandin G/H synthase 2	RCA	12239223	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P00054	Toll receptor signaling pathway	P01352	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02756	N-acetylglucosamine metabolism	P03041	Glucosamine-6-phosphate deaminase	STRCO|EnsemblGenome=CAB94621|UniProtKB=Q9K487	Glucosamine-6-phosphate deaminase	ISS			PTHR11280:SF5	GLUCOSAMINE-6-PHOSPHATE ISOMERASE
P02751	Lysine biosynthesis	P03008	Dihydrodipicolinate synthase	PSEAE|EnsemblGenome=PA4188|UniProtKB=Q9HWJ3	Uncharacterized protein	ISS			PTHR12128:SF15	4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL
P02744	Fructose galactose metabolism	P02966	Hexokinase	MACMU|Ensembl=ENSMMUG00000015302|UniProtKB=F6Q724	Uncharacterized protein	RCA			PTHR19443:SF10	HEXOKINASE-1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CHICK|Gene=ACTR2|UniProtKB=P53488	Actin-related protein 2	ISS	11889126	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00021	FGF signaling pathway	P00628	JNK1-3	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IGI			PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01437	TCF	XENTR|Xenbase=XB-GENE-485517|UniProtKB=F6WCX0	Uncharacterized protein	ISS	9039917	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	DANRE|ZFIN=ZDB-GENE-040625-167|UniProtKB=Q6IQP4	RAP1A, member of RAS oncogene family	ISS	10476970	PubMed	PTHR24070:SF284	RAP1A, MEMBER OF RAS ONCOGENE FAMILY
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	MONDO|Ensembl=ENSMODG00000003244|UniProtKB=F6THF0	Uncharacterized protein	ISS			PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	9009705	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	IDA	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00019	Endothelin signaling pathway	P00568	PKC	SCHPO|PomBase=SPBC12D12.04c|UniProtKB=P36583	Protein kinase C-like 2	IGI	93259141	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P02746	Heme biosynthesis	P02972	Ferrochelatase	MYCTU|EnsemblGenome=Rv1485|UniProtKB=P9WNE3	Ferrochelatase	ISS			PTHR11108:SF1	FERROCHELATASE, MITOCHONDRIAL
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IC	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	PANTR|Ensembl=ENSPTRG00000018684|UniProtKB=C7G3M7	Glutamate receptor, metabotropic 1	ISS	8314195	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	PANTR|Ensembl=ENSPTRG00000019449|UniProtKB=H2QV01	Actin related protein 2/3 complex, subunit 1B, 41kDa	ISS	12963527	gi	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00010	B cell activation	P00379	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00001	Adrenaline and noradrenaline biosynthesis	P00062	TH	BOVIN|Gene=TH|UniProtKB=P17289	Tyrosine 3-monooxygenase	ISS	12480184	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01311	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00056	VEGF signaling pathway	P01423	p38MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00010	B cell activation	P00383	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00636	FGFR1-4	XENTR|Xenbase=XB-GENE-1018296|UniProtKB=F6YFR4	Fibroblast growth factor receptor	ISS	1284237	PubMed	PTHR24416:SF130	FIBROBLAST GROWTH FACTOR RECEPTOR 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	PANTR|Ensembl=ENSPTRG00000006342|UniProtKB=H2Q8A8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00005	Angiogenesis	P00221	JNK1	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00640	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	IGI	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	HUMAN|HGNC=4583|UniProtKB=Q16478	Glutamate receptor ionotropic, kainate 5	ISS	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P05734	Synaptic vesicle trafficking	P05778	SNAP-25	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02783	Tryptophan biosynthesis	P03208	Tryptophan synthase B	ECOLI|EcoGene=EG11025|UniProtKB=P0A879	Tryptophan synthase beta chain	ISS			PTHR42882:SF1	TRYPTOPHAN SYNTHASE
P00006	Apoptosis signaling pathway	P00318	PKCs	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	IDA	10395542	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00006	Apoptosis signaling pathway	P00269	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	9298898	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00001	Adrenaline and noradrenaline biosynthesis	P00065	DAT	MACMU|Ensembl=ENSMMUG00000005198|UniProtKB=Q7JHP9	Transporter	ISS	15135042	PubMed	PTHR11616:SF38	SODIUM-DEPENDENT DOPAMINE TRANSPORTER
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00036	Interleukin signaling pathway	P00990	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	DANRE|ZFIN=ZDB-GENE-030131-7595|UniProtKB=Q6PBR4	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	MOUSE|MGI=MGI=1201670|UniProtKB=O35226	26S proteasome non-ATPase regulatory subunit 4	ISS	10505793	PubMed	PTHR10223:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04398	p53 pathway feedback loops 2	G04711	SIAH-1	MOUSE|MGI=MGI=108064|UniProtKB=P61092	E3 ubiquitin-protein ligase SIAH1A	IDA	14985507	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00048	PI3 kinase pathway	P01188	Gbetagamma	SCHPO|PomBase=SPBC32H8.07|UniProtKB=Q10282	Guanine nucleotide-binding protein subunit beta	IC	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00057	Wnt signaling pathway	P01455	Smad4	CANLF|Ensembl=ENSCAFG00000001094|UniProtKB=E2RCX7	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF36	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	10669416	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00022	General transcription by RNA polymerase I	P00657	TBP	METAC|EnsemblGenome=MA_4331|UniProtKB=Q8TI26	TATA-box-binding protein 1	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00037	Ionotropic glutamate receptor pathway	P01001	KA4	RAT|RGD=2734|UniProtKB=Q01812	Glutamate receptor ionotropic, kainate 4	IEA	12778120	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P05918	p38 MAPK pathway	P06023	MEF	MACMU|Ensembl=ENSMMUG00000016696|UniProtKB=F6VLM2	Uncharacterized protein	ISS			PTHR11945:SF23	MYOCYTE-SPECIFIC ENHANCER FACTOR 2D
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00551	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00205	GAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	227170	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00981	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00018	EGF receptor signaling pathway	P00560	Raf-1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00780	Microtubule	PRIPA|Gene=PPA02894|UniProtKB=H3DZP3	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF120	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00551	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	IGI	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CAEEL|WormBase=WBGene00000858|UniProtKB=P34889	Protein Wnt-2	TAS	11266476	PubMed	PTHR12027:SF77	PROTEIN WNT-5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00053	T cell activation	P01307	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	HUMAN|HGNC=9508|UniProtKB=P49768	Presenilin-1	IDA	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MACMU|Ensembl=ENSMMUG00000019305|UniProtKB=F6S3T8	Ribosomal protein S6 kinase	ISS	15116068	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00757	beta-arrestin	MOUSE|MGI=MGI=98227|UniProtKB=P20443	S-arrestin	IDA	10206946	PubMed	PTHR11792:SF15	S-ARRESTIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ORNAN|Ensembl=ENSOANG00000007405|UniProtKB=F7CIV4	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P05915	Opioid proenkephalin pathway	P05994	G-protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	ISS	11535291	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00029	Huntington disease	P00778	NMDA receptor	MACMU|Ensembl=ENSMMUG00000019112|UniProtKB=F6T8S6	N-methyl D-aspartate receptor subtype 2B	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02746	Heme biosynthesis	P02979	porphobilinogen synthase	ARATH|TAIR=AT1G69740|UniProtKB=Q9SFH9	Delta-aminolevulinic acid dehydratase 1, chloroplastic	ISS			PTHR11458:SF0	DELTA-AMINOLEVULINIC ACID DEHYDRATASE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	HUMAN|HGNC=4579|UniProtKB=P39086	Glutamate receptor ionotropic, kainate 1	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00005	Angiogenesis	P00256	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00048	PI3 kinase pathway	P01188	Gbetagamma	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00005	Angiogenesis	P00206	Wnt	RAT|RGD=1304988|UniProtKB=A0A0G2K6Q8	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00004	Alzheimer disease-presenilin pathway	P00114	actin	TRIAD|EnsemblGenome=TriadG49626|UniProtKB=B3RKR4	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00035	Interferon-gamma signaling pathway	P00952	Jak2	MOUSE|MGI=MGI=96629|UniProtKB=Q62120	Tyrosine-protein kinase JAK2	TAS	22482294	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	ECOLI|EcoGene=EG13908|UniProtKB=P78061	Gamma-glutamylputrescine synthetase PuuA	ISS			PTHR43785:SF1	TYPE-1 GLUTAMINE SYNTHETASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00857	IkappaB	MOUSE|MGI=MGI=104741|UniProtKB=Q9Z1E3	NF-kappa-B inhibitor alpha	ISS	99081292	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	MOUSE|MGI=MGI=1351342|UniProtKB=Q3UVX5	Metabotropic glutamate receptor 5	ISS	12488551	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P05916	Opioid prodynorphin pathway	G06047	preprodynorphin	PANTR|Ensembl=ENSPTRG00000013172|UniProtKB=H2QJT9	Uncharacterized protein	ISS	131330	OMIM	PTHR11438:SF4	PROENKEPHALIN-B
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	PSEAE|EnsemblGenome=PA4022|UniProtKB=Q9HX05	Probable aldehyde dehydrogenase	IC			PTHR43111:SF1	ALDEHYDE DEHYDROGENASE B
P00059	p53 pathway	P04633	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	BOVIN|Ensembl=ENSBTAG00000009269|UniProtKB=F1MCM2	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00029	Huntington disease	G01529	Proline oxidase	HUMAN|HGNC=17325|UniProtKB=Q9UF12	Probable proline dehydrogenase 2	NAS			PTHR13914:SF5	PROLINE DEHYDROGENASE 2-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00470	F-actin	TAKRU|Ensembl=ENSTRUG00000004787|UniProtKB=P53480	Actin, alpha cardiac	IC	11889139	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	PANTR|Ensembl=ENSPTRG00000009928|UniProtKB=H2QED2	Uncharacterized protein	ISS			PTHR44152:SF1	HISTAMINE H4 RECEPTOR
P00005	Angiogenesis	P00254	GTPase	DROME|FlyBase=FBgn0014020|UniProtKB=P48148	Ras-like GTP-binding protein Rho1	ISS			PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	PANTR|Ensembl=ENSPTRG00000013424|UniProtKB=H2QK86	Uncharacterized protein	ISS			PTHR24095:SF126	ACETYL-COENZYME A SYNTHETASE, CYTOPLASMIC
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000000985|UniProtKB=F6VRS9	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00021	FGF signaling pathway	P00627	ERK1-2	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	ISS	19114921	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00020	FAS signaling pathway	P00615	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	ORNAN|Ensembl=ENSOANG00000004378|UniProtKB=F7C9L2	CTP synthase	ISS			PTHR11550:SF8	CTP SYNTHASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00019	Endothelin signaling pathway	P00568	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IGI	22246731	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000010561|UniProtKB=H2R1K2	Uncharacterized protein	ISS	8386525	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	HUMAN|HGNC=3023|UniProtKB=P14416	D(2) dopamine receptor	ISS	2137198	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00006	Apoptosis signaling pathway	P00302	ATF	CANLF|Ensembl=ENSCAFG00000017042|UniProtKB=E2QYK4	Uncharacterized protein	ISS			PTHR23351:SF10	JUN DIMERIZATION PROTEIN 2
P04393	Ras Pathway	P04557	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	IDA	12040174	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00011	Blood coagulation	P00428	alpha2-antiplasmin	MOUSE|MGI=MGI=107173|UniProtKB=Q61247	Alpha-2-antiplasmin	ISS	6679383	gi	PTHR11461:SF20	ALPHA-2-ANTIPLASMIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=2183924|UniProtKB=Q8K3H5	Myosin-IIIa	IC			PTHR13140:SF387	MYOSIN-IIIA
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CANLF|Ensembl=ENSCAFG00000017575|UniProtKB=Q076A5	Myosin-4	ISS	10938134	PubMed	PTHR13140:SF657	MYOSIN-4
P04393	Ras Pathway	P04556	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT1G10210|UniProtKB=Q39021	Mitogen-activated protein kinase 1	ISS	11707292	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	97102671	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00003	Alzheimer disease-amyloid secretase pathway	P00089	Pen-2	HUMAN|HGNC=30100|UniProtKB=Q9NZ42	Gamma-secretase subunit PEN-2	IDA	12110170	PubMed	PTHR16318:SF0	GAMMA-SECRETASE SUBUNIT PEN-2
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00059	p53 pathway	P04630	PP2A	BOVIN|Ensembl=ENSBTAG00000000469|UniProtKB=P67774	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	HUMAN|HGNC=6692|UniProtKB=Q07954	Prolow-density lipoprotein receptor-related protein 1	IDA	11907044	PubMed	PTHR44025:SF2	PROLOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00830	Lipoxygenase	MOUSE|MGI=MGI=1274790|UniProtKB=P55249	Arachidonate 12-lipoxygenase, epidermal-type	TAS	12432925	PubMed	PTHR11771:SF34	ARACHIDONATE 12-LIPOXYGENASE, EPIDERMAL-TYPE
P00018	EGF receptor signaling pathway	P00539	14-3-3	CANLF|Ensembl=ENSCAFG00000031015|UniProtKB=J9P6N4	Uncharacterized protein	ISS	6756037	gi	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00047	PDGF signaling pathway	P01160	IP3 receptor	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	BACSU|EnsemblGenome=BSU15520|UniProtKB=P25994	Carbamoyl-phosphate synthase pyrimidine-specific large chain	ISS			PTHR11405:SF5	CAD PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=3763|UniProtKB=P30680	Somatostatin receptor type 2	IDA	12562507	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P00005	Angiogenesis	P00221	JNK1	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	HUMAN|HGNC=1388|UniProtKB=O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	15699344	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00018	EGF receptor signaling pathway	P00560	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	DROME|FlyBase=FBgn0004623|UniProtKB=P29829	Guanine nucleotide-binding protein subunit beta-2	IC			PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00048	PI3 kinase pathway	P01192	p110	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MOUSE|MGI=MGI=102705|UniProtKB=P63213	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IDA	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00060	Ubiquitin proteasome pathway	P01491	E2	DANRE|ZFIN=ZDB-GENE-050417-288|UniProtKB=Q4V9I8	Uncharacterized protein	ISS			PTHR24067:SF154	UBIQUITIN-CONJUGATING ENZYME E2 G2
P00012	Cadherin signaling pathway	P00470	F-actin	PHYPA|Gene=PHYPADRAFT_107830|UniProtKB=A9TBG2	Actin 7	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00047	PDGF signaling pathway	P01162	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06756	LHX2	MOUSE|MGI=MGI=96785|UniProtKB=Q9Z0S2	LIM/homeobox protein Lhx2	RCA			PTHR24208:SF90	LIM/HOMEOBOX PROTEIN LHX2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CHICK|Ensembl=ENSGALG00000014539|UniProtKB=F1N861	Uncharacterized protein	ISS	1321498	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00053	T cell activation	P01335	jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=15983|UniProtKB=P56704	Protein Wnt-3a	IDA	8717036	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00029	Huntington disease	P00789	PSD-95	MACMU|Ensembl=ENSMMUG00000010536|UniProtKB=F7D120	Uncharacterized protein	ISS	12932731	PubMed	PTHR23119:SF33	DISKS LARGE HOMOLOG 4
P00046	Oxidative stress response	P01135	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	RAT|RGD=620632|UniProtKB=Q9WVB9	Segment polarity protein dishevelled homolog DVL-1	TAS	7906389	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P00050	Plasminogen activating cascade	P01250	MMP-13	RAT|RGD=620196|UniProtKB=P23097	Collagenase 3 (Fragment)	ISS	12834808	PubMed	PTHR10201:SF165	COLLAGENASE 3
P00012	Cadherin signaling pathway	P00475	Frizzled	DANRE|ZFIN=ZDB-GENE-990415-224|UniProtKB=F1QBI2	Uncharacterized protein	IDA	8717036	PubMed	PTHR11309:SF34	FRIZZLED-2
P00060	Ubiquitin proteasome pathway	P01491	E2	CAEBR|Gene=CBG10037|UniProtKB=A8XA84	Protein CBR-UBC-7	ISS			PTHR24067:SF3	UBIQUITIN-CONJUGATING ENZYME E2 G1
P00029	Huntington disease	P00805	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000014707|UniProtKB=F7GBV2	Uncharacterized protein	ISS	8120095	PubMed	PTHR24026:SF38	CADHERIN EGF LAG SEVEN-PASS G-TYPE RECEPTOR 3
P00010	B cell activation	P00376	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00053	T cell activation	P01311	Raf	MOUSE|MGI=MGI=88190|UniProtKB=P28028	Serine/threonine-protein kinase B-raf	IDA	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00925	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	MOUSE|MGI=MGI=88276|UniProtKB=Q02248	Catenin beta-1	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00005	Angiogenesis	P00208	MEKK1	MACMU|Ensembl=ENSMMUG00000012387|UniProtKB=F7EB20	Uncharacterized protein	ISS	12168099	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MONDO|Ensembl=ENSMODG00000021434|UniProtKB=F7CB49	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00936	PI3K	CAEEL|WormBase=WBGene00006932|UniProtKB=Q9TXI7	Phosphatidylinositol 3-kinase catalytic subunit type 3	IPI	11927551	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00049	Parkinson disease	P01238	14-3-3	MOUSE|MGI=MGI=1891831|UniProtKB=O70456	14-3-3 protein sigma	ISS	10407019	PubMed	PTHR18860:SF14	14-3-3 PROTEIN SIGMA
P00036	Interleukin signaling pathway	P00968	Ikk	CANLF|Ensembl=ENSCAFG00000005526|UniProtKB=E2RKR0	Uncharacterized protein	ISS	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00056	VEGF signaling pathway	P01423	p38MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00048	PI3 kinase pathway	P01185	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00005	Angiogenesis	P00237	FRP	CANLF|Ensembl=ENSCAFG00000008293|UniProtKB=E2R9M9	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF22	FRIZZLED-3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_127488|UniProtKB=C3XYC7	Putative uncharacterized protein	IDA	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	RAT|RGD=620761|UniProtKB=Q9R172	Neurogenic locus notch homolog protein 3	IDA	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00018	EGF receptor signaling pathway	P00539	14-3-3	HUMAN|HGNC=12855|UniProtKB=P63104	14-3-3 protein zeta/delta	ISS	12615066	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00056	VEGF signaling pathway	P01402	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	RCA			PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05913	Enkephalin release	P05974	G-Protein (i)	CHICK|Ensembl=ENSGALG00000027629|UniProtKB=Q5ZJ03	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	RAT|RGD=3568|UniProtKB=P49800	Regulator of G-protein signaling 5	IDA	8756726	PubMed	PTHR10845:SF42	REGULATOR OF G-PROTEIN SIGNALING 5
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	IXOSC|EnsemblGenome=ISCW009711|UniProtKB=B7Q3T6	THO complex subunit, putative	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	TAKRU|Ensembl=ENSTRUG00000015938|UniProtKB=H2UUX5	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00049	Parkinson disease	P01219	SAPK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	NAS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00648	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00046	Oxidative stress response	P01135	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P02753	Methionine biosynthesis	P03024	Homocysteine transmethylase	ECOLI|EcoGene=EG13343|UniProtKB=Q47690	Homocysteine S-methyltransferase	ISS			PTHR21091:SF123	FI01821P
P00021	FGF signaling pathway	P00628	JNK1-3	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	IGI			PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	IC	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00057	Wnt signaling pathway	P01428	Frizzled	MACMU|Ensembl=ENSMMUG00000013656|UniProtKB=F7GI70	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF126	FRIZZLED-5
P00034	Integrin signalling pathway	P00920	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	IPI	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	HUMAN|HGNC=1060|UniProtKB=P32302	C-X-C chemokine receptor type 5	ISS	6680790	gi	PTHR10489:SF618	C-X-C CHEMOKINE RECEPTOR TYPE 5
P00019	Endothelin signaling pathway	P00566	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	HUMAN|HGNC=4579|UniProtKB=P39086	Glutamate receptor ionotropic, kainate 1	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00021	FGF signaling pathway	P00629	PP2A	IXOSC|EnsemblGenome=ISCW014549|UniProtKB=B7QGY5	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01324	rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00053	T cell activation	P01315	Calcineurin	MONDO|Ensembl=ENSMODG00000020679|UniProtKB=F7DKU1	Serine/threonine-protein phosphatase	ISS	7532676	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	IC	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00053	T cell activation	P01297	MEKK	RAT|RGD=620966|UniProtKB=Q62925	Mitogen-activated protein kinase kinase kinase 1	RCA	8643568	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	TAKRU|Ensembl=ENSTRUG00000000313|UniProtKB=H2RKP2	Clathrin heavy chain	ISS	9388255	PubMed	PTHR10292:SF1	CLATHRIN HEAVY CHAIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	XENTR|Xenbase=XB-GENE-1010483|UniProtKB=F7AF72	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	HUMAN|HGNC=7884|UniProtKB=Q99466	Neurogenic locus notch homolog protein 4	IDA	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00047	PDGF signaling pathway	P01150	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05731	GABA-B receptor II signaling	P05754	Ggamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	RCA	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ARATH|TAIR=AT2G20580|UniProtKB=Q9SIV2	26S proteasome non-ATPase regulatory subunit 2 homolog A	ISS			PTHR10943:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2
P00036	Interleukin signaling pathway	P00965	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05918	p38 MAPK pathway	P06025	SRF	MONDO|Ensembl=ENSMODG00000018981|UniProtKB=F7FP88	Uncharacterized protein	ISS	15326221	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00049	Parkinson disease	P01238	14-3-3	CHLRE|EnsemblGenome=CHLREDRAFT_185967|UniProtKB=A8JGV6	14-3-3 protein	IDA	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00009	Axon guidance mediated by netrin	P00363	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	HUMAN|HGNC=1952|UniProtKB=P20309	Muscarinic acetylcholine receptor M3	ISS	10069496	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00021	FGF signaling pathway	P00644	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	ISS	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04396	Vitamin D metabolism and pathway	G04688	24-Hydroxylase	HUMAN|HGNC=2602|UniProtKB=Q07973	1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	IDA	11686044	PubMed	PTHR24291:SF5	1,25-DIHYDROXYVITAMIN D 3  24-HYDROXYLASE, MITOCHONDRIAL
P00018	EGF receptor signaling pathway	P00546	GAP	PANTR|Ensembl=ENSPTRG00000019540|UniProtKB=H2R524	Uncharacterized protein	ISS	6635197	gi	PTHR10194:SF4	RAS GTPASE-ACTIVATING PROTEIN 4-RELATED
P00045	Notch signaling pathway	P01101	Su(H)	CAEEL|WormBase=WBGene00002245|UniProtKB=V6CLJ5	Lin-12 And Glp-1 phenotype	IGI	8625826	PubMed	PTHR10665:SF0	SUPPRESSOR OF HAIRLESS PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	MOUSE|MGI=MGI=1278315|UniProtKB=Q91VN0	Low-density lipoprotein receptor-related protein 5	ISS	11907044	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00052	TGF-beta signaling pathway	P01281	SARA	PANTR|Ensembl=ENSPTRG00000000736|UniProtKB=H2PZ11	Uncharacterized protein	ISS	10733523	PubMed	PTHR22835:SF265	ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 9
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ARATH|TAIR=AT2G42100|UniProtKB=Q8RYC2	Putative actin-5	ISS	11889126	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00059	p53 pathway	P01486	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	HUMAN|HGNC=11545|UniProtKB=Q16514	Transcription initiation factor TFIID subunit 12	ISS			PTHR12264:SF21	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12
P00021	FGF signaling pathway	P00629	PP2A	XENTR|Xenbase=XB-GENE-484003|UniProtKB=Q6P365	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00059	p53 pathway	P04623	CBP	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	IDA	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04393	Ras Pathway	P04569	Cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PANTR|Ensembl=ENSPTRG00000009762|UniProtKB=H2QE24	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CANLF|Ensembl=ENSCAFG00000008760|UniProtKB=E2RTG8	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00059	p53 pathway	P04634	Cdc2	ORNAN|Ensembl=ENSOANG00000004413|UniProtKB=F7BI12	Uncharacterized protein	ISS			PTHR24056:SF334	CYCLIN-DEPENDENT KINASE 1
P00007	Axon guidance mediated by semaphorins	P00340	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	20264070	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00029	Huntington disease	P00805	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00014	Cholesterol biosynthesis	P00493	Geranyl trans-transferase	HUMAN|HGNC=3631|UniProtKB=P14324	Farnesyl pyrophosphate synthase	ISS	O64905	SPACC	PTHR11525:SF0	FARNESYL PYROPHOSPHATE SYNTHASE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00005	Angiogenesis	P00238	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00054	Toll receptor signaling pathway	P01369	MKK1	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05957	K+ channel	MOUSE|MGI=MGI=1100509|UniProtKB=O35111	Potassium channel subfamily K member 3	ISS	15282272	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	STRCO|Gene=CAB42773|UniProtKB=Q9X8J9	Putative aldehyde dehydrogenase	IC			PTHR42986:SF1	SUBFAMILY NOT NAMED
P05913	Enkephalin release	G06045	preproenkephalin	PANTR|Ensembl=ENSPTRG00000020270|UniProtKB=H2QW70	Proenkephalin	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	IDA	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	TAKRU|Ensembl=ENSTRUG00000003589|UniProtKB=H2S7P7	Uncharacterized protein	IDA			PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	RAT|RGD=621516|UniProtKB=G3V6P8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	MOUSE|MGI=MGI=102897|UniProtKB=F6XJP7	Protein Pcsk6	IDA			PTHR42884:SF8	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 6
P00036	Interleukin signaling pathway	P00974	Receptor subunit beta	PANTR|Ensembl=ENSPTRG00000010692|UniProtKB=H2R3T4	Uncharacterized protein	ISS	8958915	PubMed	PTHR23036:SF51	INTERLEUKIN-12 RECEPTOR SUBUNIT BETA-1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P06587	Nicotine pharmacodynamics pathway	P06604	SLC18A2	BOVIN|Gene=SLC18A2|UniProtKB=Q27963	Synaptic vesicular amine transporter	ISS	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CANLF|Ensembl=ENSCAFG00000016020|UniProtKB=O18840	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00036	Interleukin signaling pathway	P00983	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IGI	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	XENTR|Xenbase=XB-GENE-976753|UniProtKB=Q0VFR6	Syntaxin 1A (Brain)	ISS	1321498	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P05915	Opioid proenkephalin pathway	P05992	met-Enkephalin	MOUSE|MGI=MGI=104629|UniProtKB=P22005	Proenkephalin-A	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06850	PKCs(3)	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	RCA	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	ANOGA|EnsemblGenome=AGAP001478|UniProtKB=Q7PXM3	AGAP001478-PA	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00049	Parkinson disease	P01227	20S proteasome	HUMAN|HGNC=9544|UniProtKB=Q99436	Proteasome subunit beta type-7	ISS	12859888	PubMed	PTHR11599:SF42	PROTEASOME SUBUNIT BETA TYPE-7
P00034	Integrin signalling pathway	P00941	Integrin alpha	MOUSE|MGI=MGI=2153482|UniProtKB=E9Q6R1	Protein Itga10	IPI	3487386	PubMed	PTHR23220:SF26	INTEGRIN ALPHA-10
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01423	p38MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	8327893	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00046	Oxidative stress response	P01126	ATF2	MOUSE|MGI=MGI=109349|UniProtKB=P16951	Cyclic AMP-dependent transcription factor ATF-2	TAS	7875593	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00005	Angiogenesis	P00231	HSP27	PANTR|Ensembl=ENSPTRG00000004274|UniProtKB=H2Q4R8	Uncharacterized protein	ISS			PTHR11527:SF37	ALPHA-CRYSTALLIN B CHAIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CAEEL|WormBase=WBGene00000067|UniProtKB=O45815	ACTin	IC	11889126	PubMed	PTHR11937:SF352	ACTIN
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	ORNAN|Ensembl=ENSOANG00000004058|UniProtKB=F6TYP9	Uncharacterized protein	ISS	20112749	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00036	Interleukin signaling pathway	P00964	p90RSK	MOUSE|MGI=MGI=104557|UniProtKB=P18654	Ribosomal protein S6 kinase alpha-3	IDA	6755374	gi	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	12885769	PubMed	PTHR10202:SF13	PRESENILIN-2
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IPI	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00046	Oxidative stress response	P01135	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04393	Ras Pathway	P04550	Ral	MONDO|Ensembl=ENSMODG00000000264|UniProtKB=F6WB97	Uncharacterized protein	ISS	10328920	PubMed	PTHR24070:SF199	RAS-RELATED PROTEIN RAL-B
P00037	Ionotropic glutamate receptor pathway	P01026	KA	BOVIN|Ensembl=ENSBTAG00000033153|UniProtKB=F1MG21	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00005	Angiogenesis	P00256	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	10395542	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	HUMAN|HGNC=2092|UniProtKB=Q00610	Clathrin heavy chain 1	IDA	9388255	PubMed	PTHR10292:SF7	CLATHRIN HEAVY CHAIN 1
P00010	B cell activation	P00381	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	RAT|RGD=2157|UniProtKB=P29067	Beta-arrestin-2	ISS	4757780	gi	PTHR11792:SF20	BETA-ARRESTIN-2
P02723	Adenine and hypoxanthine salvage pathway	P02807	Deoxyadenosine deaminase	BOVIN|Gene=ADA|UniProtKB=P56658	Adenosine deaminase	ISS			PTHR11409:SF43	ADENOSINE DEAMINASE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00029	Huntington disease	P00810	GAPDH	ORYSJ|EnsemblGenome=OS08G0126300|UniProtKB=Q0J8A4	Glyceraldehyde-3-phosphate dehydrogenase 1, cytosolic	IPI			PTHR10836:SF58	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01465	Ggamma	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00029	Huntington disease	P00810	GAPDH	RAT|RGD=2661|UniProtKB=P04797	Glyceraldehyde-3-phosphate dehydrogenase	ISS	8612237	PubMed	PTHR10836:SF51	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	MOUSE|MGI=MGI=1858304|UniProtKB=P70698	CTP synthase 1	ISS			PTHR11550:SF8	CTP SYNTHASE 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00023	General transcription regulation	P00658	TBP-associated factors	HUMAN|HGNC=11536|UniProtKB=Q6P1X5	Transcription initiation factor TFIID subunit 2	ISS			PTHR15137:SF9	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PHYPA|Gene=PHYPADRAFT_109052|UniProtKB=A9TZ58	Actin 5	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	1504106	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01417	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000001044|UniProtKB=H2PZK0	Uncharacterized protein	ISS	8120095	PubMed	PTHR24026:SF32	CADHERIN EGF LAG SEVEN-PASS G-TYPE RECEPTOR 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	HUMAN|HGNC=4595|UniProtKB=Q14832	Metabotropic glutamate receptor 3	IDA			PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00053	T cell activation	P01312	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IDA	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04393	Ras Pathway	P04552	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	MACMU|Ensembl=ENSMMUG00000001387|UniProtKB=F7D0B4	Uncharacterized protein	ISS	14580336	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00036	Interleukin signaling pathway	P00976	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	CANLF|Ensembl=ENSCAFG00000004110|UniProtKB=J9P9P7	Uncharacterized protein	ISS	11055438	PubMed	PTHR10117:SF8	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 3
P06664	Gonadotropin-releasing hormone receptor pathway	P06850	PKCs(3)	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	RCA	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00049	Parkinson disease	P01211	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01284	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	P01448	CBP	PANTR|Ensembl=ENSPTRG00000014418|UniProtKB=H2QLS0	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00023	General transcription regulation	P00662	TFIIA complex	DANRE|ZFIN=ZDB-GENE-050522-513|UniProtKB=Q503H9	Transcription initiation factor IIA subunit 2	ISS			PTHR10966:SF0	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2
P00053	T cell activation	P01318	PKC-theta	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04398	p53 pathway feedback loops 2	G04714	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00049	Parkinson disease	P01230	Src kinase	CANLF|Ensembl=ENSCAFG00000007034|UniProtKB=E2RBB8	Tyrosine-protein kinase	ISS	1371009	PubMed	PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P00018	EGF receptor signaling pathway	P00545	JNK1-3	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	RAT|RGD=69319|UniProtKB=P54313	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00001	Adrenaline and noradrenaline biosynthesis	P00070	VAT2	MACMU|Ensembl=ENSMMUG00000014817|UniProtKB=F6VXD8	Uncharacterized protein	ISS	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05916	Opioid prodynorphin pathway	P06002	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_127490|UniProtKB=C3XYC5	Putative uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P04395	Vasopressin synthesis	P04589	Signal Peptidase	PANTR|Ensembl=ENSPTRG00000007404|UniProtKB=H2QA06	Signal peptidase complex catalytic subunit SEC11	ISS	2092035	PubMed	PTHR10806:SF8	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11A-RELATED
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	HUMAN|HGNC=10934|UniProtKB=P54219	Chromaffin granule amine transporter	ISS	11443533	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P02743	Formyltetrahydroformate biosynthesis	P02952	Methylene tetrahydrofolate dehydrogenase	ECOLI|EcoGene=EG10328|UniProtKB=P24186	Bifunctional protein FolD	ISS			PTHR10025:SF46	BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, MITOCHONDRIAL
P00020	FAS signaling pathway	P00616	Nuclear Lamin	DANRE|ZFIN=ZDB-GENE-020424-2|UniProtKB=F1Q5F3	Uncharacterized protein	TAS	11165516	PubMed	PTHR23239:SF157	LAMIN-B1
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05913	Enkephalin release	P05974	G-Protein (i)	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	IC	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00053	T cell activation	P01322	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00922	Collagen	CAEBR|Gene=CBG10116|UniProtKB=A8XAF1	Protein CBR-EMB-9	ISS	10778855	PubMed	PTHR24023:SF674	COLLAGEN ALPHA-1 IV  CHAIN-RELATED
P05913	Enkephalin release	P05977	G-Protein (s)	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	PHYPA|Gene=PHYPADRAFT_210000|UniProtKB=A9S9L5	Predicted protein	ISS			PTHR23050:SF245	AT16150P-RELATED
P00006	Apoptosis signaling pathway	P00260	AKT	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01217	beta-Synuclein	RAT|RGD=70992|UniProtKB=Q63754	Beta-synuclein	IDA	11683992	PubMed	PTHR13820:SF4	BETA-SYNUCLEIN
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00643	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	TAS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IGI	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	IC	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MONDO|Ensembl=ENSMODG00000023942|UniProtKB=F7F878	Uncharacterized protein	ISS			PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P00053	T cell activation	P01322	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05987	peptide F	BOVIN|Ensembl=ENSBTAG00000004924|UniProtKB=P01211	Proenkephalin-A	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	DANRE|ZFIN=ZDB-GENE-010705-1|UniProtKB=Q90Z40	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P02774	Salvage pyrimidine deoxyribonucleotides	P03148	Thymidine phosphorylase	METAC|EnsemblGenome=MA_3242|UniProtKB=Q8TL01	AMP phosphorylase	ISS	11932238	PubMed	PTHR10515:SF0	THYMIDINE PHOSPHORYLASE
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00645	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	THEMA|EnsemblGenome=TM_0557|UniProtKB=Q9WZ27	Carbamoyl-phosphate synthase large chain	ISS			PTHR11405:SF5	CAD PROTEIN
P00007	Axon guidance mediated by semaphorins	P00340	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00059	p53 pathway	P04630	PP2A	MOUSE|MGI=MGI=1321159|UniProtKB=P63330	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=1310328|UniProtKB=G3V8N1	Protein Pcdhb22	ISS	8120095	PubMed	PTHR24028:SF97	PROTOCADHERIN BETA-15
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	RAT|RGD=2733|UniProtKB=P42260	Glutamate receptor ionotropic, kainate 2	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00046	Oxidative stress response	P01135	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	TAS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	HUMAN|HGNC=4582|UniProtKB=Q16099	Glutamate receptor ionotropic, kainate 4	ISS	11319238	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04393	Ras Pathway	P04552	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IDA	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00005	Angiogenesis	P00243	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MONDO|Ensembl=ENSMODG00000008382|UniProtKB=F7CDR6	Uncharacterized protein (Fragment)	ISS	11259498	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00021	FGF signaling pathway	P00640	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IGI	96009592	PubMed	PTHR10048:SF14	PI-3 KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00005	Angiogenesis	P00231	HSP27	MONDO|Ensembl=ENSMODG00000021030|UniProtKB=F6QYV3	Uncharacterized protein	ISS			PTHR11527:SF36	ALPHA-CRYSTALLIN A CHAIN
P00057	Wnt signaling pathway	P01446	Calcineurin	CANLF|Ensembl=ENSCAFG00000010644|UniProtKB=F2Z4P5	Serine/threonine-protein phosphatase	ISS	7532676	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	RAT|RGD=1311791|UniProtKB=Q4KLF8	Actin-related protein 2/3 complex subunit 5	ISS	12473693	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	PHYPA|Gene=PHYPADRAFT_112581|UniProtKB=A9REE1	Predicted protein	ISS			PTHR23073:SF24	26S PROTEASE REGULATORY SUBUNIT 4
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	ARATH|TAIR=AT5G07880|UniProtKB=Q9SD96	SNAP25 homologous protein SNAP29	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00055	Transcription regulation by bZIP transcription factor	P01395	TFIIE	MOUSE|MGI=MGI=1921447|UniProtKB=Q9D0D5	General transcription factor IIE subunit 1	ISS	189964	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	MACMU|Ensembl=ENSMMUG00000009928|UniProtKB=F6Y5E5	Uncharacterized protein	ISS	2433589	PubMed	PTHR11767:SF17	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 3
P00010	B cell activation	P00369	MEKK	RAT|RGD=620967|UniProtKB=F1M9D0	Protein Map3k2	ISS	11730323	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00052	TGF-beta signaling pathway	P01292	RSmads	RAT|RGD=71004|UniProtKB=O54835	Mothers against decapentaplegic homolog 9	TAS	9395284	PubMed	PTHR13703:SF41	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 9
P00004	Alzheimer disease-presenilin pathway	P00127	APP	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00005	Angiogenesis	P00184	Src	HUMAN|HGNC=11283|UniProtKB=P12931	Proto-oncogene tyrosine-protein kinase Src	ISS	11078745	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00046	Oxidative stress response	P01138	MKK4	MACMU|Ensembl=ENSMMUG00000019842|UniProtKB=F7FU91	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IGI	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04398	p53 pathway feedback loops 2	P04657	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00057	Wnt signaling pathway	P01452	NFAT	MACMU|Ensembl=ENSMMUG00000021843|UniProtKB=F6RNI3	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	HUMAN|HGNC=1389|UniProtKB=Q00975	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	14507926	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P06664	Gonadotropin-releasing hormone receptor pathway	P06818	OTX	MOUSE|MGI=MGI=97450|UniProtKB=P80205	Homeobox protein OTX1	RCA			PTHR24329:SF310	HOMEOBOX PROTEIN OTX1
P05916	Opioid prodynorphin pathway	P06002	G-protein	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	BOVIN|Ensembl=ENSBTAG00000000219|UniProtKB=F1MCL3	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00005	Angiogenesis	P00254	GTPase	DAPPU|EnsemblGenome=DAPPUDRAFT_301996|UniProtKB=E9HL06	Putative uncharacterized protein	ISS			PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	CAEEL|WormBase=WBGene00000552|UniProtKB=O16305	Calmodulin	ISS	10487978	PubMed	PTHR23050:SF236	CALMODULIN
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	TAKRU|Ensembl=ENSTRUG00000015938|UniProtKB=H2UUX5	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00009	Axon guidance mediated by netrin	P00356	UNC-5	MACMU|Ensembl=ENSMMUG00000002649|UniProtKB=F7H510	Uncharacterized protein	ISS			PTHR12582:SF4	NETRIN RECEPTOR UNC5A
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	11956331	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00034	Integrin signalling pathway	P00951	Jnk	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00009	Axon guidance mediated by netrin	P00364	cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00006	Apoptosis signaling pathway	P00301	Apaf-1	MOUSE|MGI=MGI=1306796|UniProtKB=O88879	Apoptotic protease-activating factor 1	ISS	14526190	PubMed	PTHR22845:SF5	APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
P00021	FGF signaling pathway	P00627	ERK1-2	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01275	P38	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	8920915	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00021	FGF signaling pathway	P00629	PP2A	DANRE|ZFIN=ZDB-GENE-030131-5474|UniProtKB=A2BG80	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B	ISS	11956189	PubMed	PTHR11871:SF2	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00029	Huntington disease	P00780	Microtubule	PHYPA|Gene=PHYPADRAFT_232451|UniProtKB=A9SKU2	Predicted protein	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02916	dTMP kinase	CHLTR|EnsemblGenome=CT_188|UniProtKB=O84191	Thymidylate kinase	ISS			PTHR10344:SF1	THYMIDYLATE KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05918	p38 MAPK pathway	P06031	p38alpha	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04397	p53 pathway by glucose deprivation	P04641	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	10218114	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PHYIT|EnsemblGenome=PITG_15117|UniProtKB=D0NRP9	Actin-like protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=108022|UniProtKB=P70268	Serine/threonine-protein kinase N1	ISS	10644715	PubMed	PTHR24356:SF246	SERINE/THREONINE-PROTEIN KINASE N1
P00018	EGF receptor signaling pathway	P00545	JNK1-3	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	ISS	8940199	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P04384	Gamma-aminobutyric acid synthesis	P04482	Glutamate decarboxylase	CANLF|Gene=GAD1|UniProtKB=A0PA85	Glutamate decarboxylase 1	ISS	2247446	PubMed	PTHR11999:SF57	GLUTAMATE DECARBOXYLASE 1
P00057	Wnt signaling pathway	P01438	PP2A	HUMAN|HGNC=9299|UniProtKB=P67775	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P06664	Gonadotropin-releasing hormone receptor pathway	P06849	Sos	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	RCA	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	DANRE|ZFIN=ZDB-GENE-020419-19|UniProtKB=Q8JHE0	Casein kinase 1-alphaLS	IDA	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00021	FGF signaling pathway	P00642	MEK1-2	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00054	Toll receptor signaling pathway	P01346	TLR	HUMAN|HGNC=11849|UniProtKB=O15455	Toll-like receptor 3	ISS			PTHR44599:SF1	TOLL-LIKE RECEPTOR 3
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04397	p53 pathway by glucose deprivation	P04641	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IGI	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	BOVIN|Ensembl=ENSBTAG00000009269|UniProtKB=F1MCM2	Uncharacterized protein	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00973	PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04398	p53 pathway feedback loops 2	P04665	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00047	PDGF signaling pathway	P01173	STAT	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	12191995	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00049	Parkinson disease	P01227	20S proteasome	TRYB2|Gene=Tb11.02.4870|UniProtKB=Q384W9	Proteasome subunit alpha type	TAS	12859888	PubMed	PTHR11599:SF15	PROTEASOME SUBUNIT ALPHA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02781	Threonine biosynthesis	P03191	Homoserine kinase	GLOVI|EnsemblGenome=BAC89068|UniProtKB=Q7NLJ6	Homoserine kinase	ISS			PTHR20861:SF1	HOMOSERINE KINASE
P00059	p53 pathway	G04694	p110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00470	F-actin	ARATH|TAIR=AT5G59370|UniProtKB=P53494	Actin-4	IC	14684598	PubMed	PTHR11937:SF366	ACTIN-4
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P06664	Gonadotropin-releasing hormone receptor pathway	G06886	CGA	MOUSE|MGI=MGI=88390|UniProtKB=P01216	Glycoprotein hormones alpha chain	RCA	89325834	PubMed	PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	MACMU|Ensembl=ENSMMUG00000021843|UniProtKB=F6RNI3	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P02728	Arginine biosynthesis	P02847	N-actetylornithine deacetylase	RHOBA|EnsemblGenome=RB9116|UniProtKB=Q7UM22	Acetylornithine deacetylase ArgE	ISS			PTHR43808:SF8	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00019	Endothelin signaling pathway	P00566	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IGI	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8972|UniProtKB=O00750	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P05912	Dopamine receptor mediated signaling pathway	P05949	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	4504111	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	PANTR|Ensembl=ENSPTRG00000012881|UniProtKB=H2QJC4	Uncharacterized protein	ISS			PTHR11405:SF38	CARBAMOYL-PHOSPHATE SYNTHASE  AMMONIA , MITOCHONDRIAL
P04393	Ras Pathway	P04570	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00022	General transcription by RNA polymerase I	P00657	TBP	DROME|FlyBase=FBgn0010287|UniProtKB=Q27896	TBP-related factor	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00005	Angiogenesis	P00206	Wnt	MONDO|Ensembl=ENSMODG00000012401|UniProtKB=F6PMQ6	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	10218114	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00059	p53 pathway	P04618	PML	MACMU|Ensembl=ENSMMUG00000002569|UniProtKB=F7HSN6	Uncharacterized protein	ISS	12810724	PubMed	PTHR45211:SF1	PROTEIN PML
P02728	Arginine biosynthesis	P02847	N-actetylornithine deacetylase	STRCO|Gene=CAC01340|UniProtKB=Q9FBL9	Succinyl-diaminopimelate desuccinylase	ISS			PTHR43808:SF8	SUBFAMILY NOT NAMED
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P06664	Gonadotropin-releasing hormone receptor pathway	G06891	Junc	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	RCA	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00021	FGF signaling pathway	P00645	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00056	VEGF signaling pathway	P01419	Ets	RAT|RGD=2583|UniProtKB=P41156	Protein C-ets-1	ISS	15579511	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05918	p38 MAPK pathway	P06018	MNK1	BOVIN|Gene=MKNK1|UniProtKB=Q58D94	MAP kinase-interacting serine/threonine-protein kinase 1	ISS	9155017	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	HUMAN|HGNC=4584|UniProtKB=Q05586	Glutamate receptor ionotropic, NMDA 1	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00021	FGF signaling pathway	P00634	MEKK1-5	RAT|RGD=620967|UniProtKB=F1M9D0	Protein Map3k2	ISS	11730323	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P05916	Opioid prodynorphin pathway	P06002	G-protein	CRYNJ|EnsemblGenome=CND03830|UniProtKB=Q5KI86	Uncharacterized protein	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00059	p53 pathway	P04630	PP2A	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ORYSJ|EnsemblGenome=OS06G0154500|UniProtKB=Q84UI5	Mitogen-activated protein kinase 1	ISS			PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CHICK|Ensembl=ENSGALG00000012894|UniProtKB=P30372	Muscarinic acetylcholine receptor M2	IDA	12181435	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00047	PDGF signaling pathway	P01153	GSK3	ARATH|TAIR=AT3G61160|UniProtKB=O23145	Shaggy-related protein kinase beta	ISS	21361340	gi	PTHR24057:SF19	SHAGGY-RELATED PROTEIN KINASE BETA-RELATED
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00752	cGMP-gated ion channel	RAT|RGD=70948|UniProtKB=Q9ER33	Cyclic nucleotide gated channel alpha 3, isoform CRA_a	IDA	12432397	PubMed	PTHR10217:SF390	CYCLIC NUCLEOTIDE-GATED CATION CHANNEL ALPHA-3
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02738	De novo purine biosynthesis	P02899	GMP synthase	THEMA|EnsemblGenome=TM_1820|UniProtKB=Q9X2E0	GMP synthase [glutamine-hydrolyzing]	ISS			PTHR11922:SF2	GMP SYNTHASE  GLUTAMINE-HYDROLYZING
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00046	Oxidative stress response	P01131	MKP5	HUMAN|HGNC=20476|UniProtKB=Q9H596	Dual specificity protein phosphatase 21	TAS			PTHR10159:SF386	DUAL SPECIFICITY PROTEIN PHOSPHATASE 21
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00029	Huntington disease	P00807	Actin	ARATH|TAIR=AT2G42090|UniProtKB=P93738	Putative actin-9	IDA	11889126	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00034	Integrin signalling pathway	P00913	Csk	CANLF|Ensembl=ENSCAFG00000017945|UniProtKB=E2RFF7	Tyrosine-protein kinase	ISS	7687537	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00010	B cell activation	P00398	IP3R	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	IGI	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-050417-59|UniProtKB=Q15KE4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00014	Cholesterol biosynthesis	P00491	Hydroxymethyl glutaryl CoA reductase	DICDI|dictyBase=DDB_G0276615|UniProtKB=P34136	3-hydroxy-3-methylglutaryl-coenzyme A reductase 2	TAS	P34136	SPACC	PTHR10572:SF16	3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	CHICK|Ensembl=ENSGALG00000009927|UniProtKB=Q5ZHX1	Ras-related protein Rap-1b	ISS	10476970	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P02729	Ascorbate degradation	P02852	L-xylulose-5-phosphate-3-epimerase	HUMAN|HGNC=10293|UniProtKB=Q96AT9	Ribulose-phosphate 3-epimerase	ISS			PTHR11749:SF3	RIBULOSE-PHOSPHATE 3-EPIMERASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	ISS	94280860	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DANRE|ZFIN=ZDB-GENE-030131-6503|UniProtKB=Q7ZUC5	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF297	PROTEIN KINASE C DELTA TYPE
P00048	PI3 kinase pathway	P01192	p110	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00009	Axon guidance mediated by netrin	P00363	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	129387	gi	PTHR10048:SF14	PI-3 KINASE
P00021	FGF signaling pathway	P00642	MEK1-2	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DICDI|dictyBase=DDB_G0275023|UniProtKB=Q553U6	Putative actin-22	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02738	De novo purine biosynthesis	P02907	dADP kinase	PANTR|Ensembl=ENSPTRG00000017279|UniProtKB=H2QRJ9	Uncharacterized protein	ISS			PTHR11349:SF64	NUCLEOSIDE DIPHOSPHATE KINASE HOMOLOG 5
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IGI	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05916	Opioid prodynorphin pathway	P06002	G-protein	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00036	Interleukin signaling pathway	P00983	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00561	STAT	RAT|RGD=3772|UniProtKB=P52631	Signal transducer and activator of transcription 3	IGI	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MACMU|Ensembl=ENSMMUG00000022347|UniProtKB=F6ZCH5	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DROME|FlyBase=FBgn0259680|UniProtKB=P83099	Putative protein kinase C delta type homolog	ISS	2837282	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	DROME|FlyBase=FBgn0024941|UniProtKB=Q9VXA3	LP21163p	IDA	8756726	PubMed	PTHR10845:SF151	LP21163P
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	HUMAN|HGNC=17383|UniProtKB=Q9H3N8	Histamine H4 receptor	IDA			PTHR44152:SF1	HISTAMINE H4 RECEPTOR
P00021	FGF signaling pathway	P00632	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05918	p38 MAPK pathway	P06027	CREB	MONDO|Ensembl=ENSMODG00000015970|UniProtKB=F7FD05	Uncharacterized protein	ISS	14604761	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00018	EGF receptor signaling pathway	P00561	STAT	RAT|RGD=3772|UniProtKB=P52631	Signal transducer and activator of transcription 3	IGI	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	BOVIN|Ensembl=ENSBTAG00000008059|UniProtKB=P41984	Muscarinic acetylcholine receptor M3	ISS	11166329	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00017	DNA replication	P00531	Pol alpha	RAT|RGD=621816|UniProtKB=O89042	DNA polymerase alpha catalytic subunit (Fragment)	IDA	20009599	PubMed	PTHR10322:SF21	DNA POLYMERASE ALPHA CATALYTIC SUBUNIT
P02774	Salvage pyrimidine deoxyribonucleotides	P03147	Thymidine kinase	CHICK|Ensembl=ENSGALG00000007191|UniProtKB=P04047	Thymidine kinase, cytosolic	ISS			PTHR11441:SF0	THYMIDINE KINASE, CYTOSOLIC
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000003399|UniProtKB=H2Q383	Phosphoinositide-3-kinase, class 2, alpha polypeptide	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00005	Angiogenesis	P00244	MAPKAPK2/3	BOVIN|Ensembl=ENSBTAG00000038107|UniProtKB=F1MCX5	Uncharacterized protein	ISS	8262198	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00036	Interleukin signaling pathway	P00990	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	ANOGA|EnsemblGenome=AGAP001506|UniProtKB=Q7PXP3	AGAP001506-PA	IC			PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00010	B cell activation	P00384	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P02783	Tryptophan biosynthesis	P03206	Anthranilate synthase	SCHPO|PomBase=SPBC1539.09c|UniProtKB=Q92370	Multifunctional tryptophan biosynthesis protein	RCA			PTHR43418:SF4	MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN
P00036	Interleukin signaling pathway	P00977	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	NAS	8920915	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00060	Ubiquitin proteasome pathway	P01491	E2	CHLRE|EnsemblGenome=CHLREDRAFT_187409|UniProtKB=Q8VZX3	Ubiquitin-conjugating enzyme E2	ISS			PTHR43915:SF5	LD28904P
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DAPPU|EnsemblGenome=DAPPUDRAFT_188187|UniProtKB=E9GJ31	Guanine nucleotide binding protein, q polypeptide	ISS	1333286	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P04393	Ras Pathway	P04547	Ras	CAEEL|WormBase=WBGene00002335|UniProtKB=P22981	Ras protein let-60	IDA	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P04395	Vasopressin synthesis	P04596	Endo Peptidase	DEIRA|EnsemblGenome=DR_2503|UniProtKB=Q9RRI7	Prolyl endopeptidase	IC	9695945	PubMed	PTHR42881:SF2	PROLYL ENDOPEPTIDASE
P00018	EGF receptor signaling pathway	P00564	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	8649368	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00047	PDGF signaling pathway	P01171	PLCgamma	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	RCA	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00049	Parkinson disease	P01212	p38 MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	NAS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00729	Goalpha	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	IDA	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01150	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00030	Hypoxia response via HIF activation	P00819	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04556	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	HUMAN|HGNC=1392|UniProtKB=Q15878	Voltage-dependent R-type calcium channel subunit alpha-1E	IDA	14624853	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	HUMAN|HGNC=9997|UniProtKB=O15492	Regulator of G-protein signaling 16	IDA	8756726	PubMed	PTHR10845:SF187	REGULATOR OF G-PROTEIN SIGNALING 16
P00021	FGF signaling pathway	P00626	Spry	MACMU|Ensembl=ENSMMUG00000014175|UniProtKB=F7ALK4	Uncharacterized protein	ISS	99264295	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P00029	Huntington disease	P00780	Microtubule	PHYIT|EnsemblGenome=PITG_00156|UniProtKB=D0MT13	Beta-tubulin	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P06959	CCKR signaling map	P07152	AKT1	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	RCA	12829245	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01438	PP2A	RAT|RGD=3381|UniProtKB=P62716	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	DROME|FlyBase=FBgn0001098|UniProtKB=P54385	Glutamate dehydrogenase, mitochondrial	ISS			PTHR11606:SF13	GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00981	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00049	Parkinson disease	P01230	Src kinase	MONDO|Ensembl=ENSMODG00000009310|UniProtKB=F7GJZ7	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00029	Huntington disease	P00776	c-Jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00005	Angiogenesis	P00193	SOS-1	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Ensembl=ENSPTRG00000011042|UniProtKB=H2QGF5	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000000289|UniProtKB=F7A9T0	Uncharacterized protein	ISS	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00036	Interleukin signaling pathway	P00981	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	ISS	11319238	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	THEMA|EnsemblGenome=TM_1015|UniProtKB=P96110	Glutamate dehydrogenase	ISS			PTHR11606:SF13	GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL
P00060	Ubiquitin proteasome pathway	P01491	E2	CANLF|Ensembl=ENSCAFG00000031041|UniProtKB=J9NS22	Uncharacterized protein	ISS			PTHR24068:SF40	UBIQUITIN-CONJUGATING ENZYME E2 D2-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MOUSE|MGI=MGI=95822|UniProtKB=Q01098	Glutamate receptor ionotropic, NMDA 2C	IC	11319238	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	BOVIN|Ensembl=ENSBTAG00000007882|UniProtKB=G3X7Z2	Uncharacterized protein	IDA	11976940	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00056	VEGF signaling pathway	P01414	PLC-gamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00648	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	IGI	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	IC	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00005	Angiogenesis	P00220	c-Jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00021	FGF signaling pathway	P00629	PP2A	DANRE|ZFIN=ZDB-GENE-050417-441|UniProtKB=Q567Y8	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01322	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	RAT|RGD=1566295|UniProtKB=Q3T1L0	Aldehyde dehydrogenase family 16 member A1	ISS			PTHR11699:SF98	ALDEHYDE DEHYDROGENASE FAMILY 16 MEMBER A1
P00019	Endothelin signaling pathway	P00587	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	STRCO|EnsemblGenome=CAA20396|UniProtKB=O86781	Glutamine--fructose-6-phosphate aminotransferase [isomerizing]	ISS			PTHR10937:SF0	GH12731P-RELATED
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	TAKRU|Ensembl=ENSTRUG00000007989|UniProtKB=P68140	Actin, alpha skeletal muscle A	ISS	11889139	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	MOUSE|MGI=MGI=109482|UniProtKB=P97445	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	8386525	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00046	Oxidative stress response	P01135	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	TAS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00540	MKK3,6	HUMAN|HGNC=6846|UniProtKB=P52564	Dual specificity mitogen-activated protein kinase kinase 6	ISS	8622669	PubMed	PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00758	Phosducin	MOUSE|MGI=MGI=98090|UniProtKB=Q9QW08	Phosducin	IDA	10360181	PubMed	PTHR21148:SF17	PHOSDUCIN
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02731	Biotin biosynthesis	P02857	Biotin synthase	BACTN|EnsemblGenome=BT_1835|UniProtKB=Q8A6P2	Biotin synthase	ISS			PTHR43726:SF1	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00951	Jnk	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	IDA	12040174	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00035	Interferon-gamma signaling pathway	P00954	Interferongamma	CHICK|Ensembl=ENSGALG00000009903|UniProtKB=P49708	Interferon gamma	TAS	11929133	PubMed	PTHR11419:SF0	INTERFERON GAMMA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000007882|UniProtKB=G3X7Z2	Uncharacterized protein	ISS	14624853	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00021	FGF signaling pathway	P00629	PP2A	YEAST|SGD=S000002347|UniProtKB=P23595	Serine/threonine-protein phosphatase PP2A-2 catalytic subunit	ISS			PTHR11668:SF242	SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-1 CATALYTIC SUBUNIT-RELATED
P00049	Parkinson disease	P01214	CHIP	PANTR|Ensembl=ENSPTRG00000007553|UniProtKB=H2QA80	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase	ISS	12150907	PubMed	PTHR44284:SF1	E3 UBIQUITIN-PROTEIN LIGASE CHIP
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	XENTR|Xenbase=XB-GENE-969601|UniProtKB=Q28H40	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00048	PI3 kinase pathway	P01185	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04392	P53 pathway feedback loops 1	G04685	p73DeltaN	CHICK|Ensembl=ENSGALG00000007324|UniProtKB=F1N8Z7	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MOUSE|MGI=MGI=1336171|UniProtKB=Q9DAS9	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00034	Integrin signalling pathway	P00916	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IPI	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	CANLF|Ensembl=ENSCAFG00000013324|UniProtKB=F1PCS0	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2747|UniProtKB=P35349	Metabotropic glutamate receptor 6	IDA	12488551	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MACMU|Gene=CHRM1|UniProtKB=P56489	Muscarinic acetylcholine receptor M1	TAS	8100450	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00020	FAS signaling pathway	P00611	Gelsolin	PANTR|Ensembl=ENSPTRG00000018941|UniProtKB=H2QU73	Uncharacterized protein	ISS	9323209	PubMed	PTHR11977:SF78	ADSEVERIN
P00029	Huntington disease	P00774	Dynein complex	ORNAN|Ensembl=ENSOANG00000015679|UniProtKB=F7EXB7	Uncharacterized protein	ISS	9454836	PubMed	PTHR11886:SF52	DYNEIN LIGHT CHAIN 1, CYTOPLASMIC
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	IDA	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00045	Notch signaling pathway	G01541	E(spl)-C genes	BOVIN|Ensembl=ENSBTAG00000000919|UniProtKB=E1BEV8	Uncharacterized protein	ISS			PTHR10985:SF88	HAIRY/ENHANCER-OF-SPLIT RELATED WITH YRPW MOTIF PROTEIN 2
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MONDO|Ensembl=ENSMODG00000001775|UniProtKB=F6WJB1	Uncharacterized protein	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00025	Hedgehog signaling pathway	P00682	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CANLF|Ensembl=ENSCAFG00000008756|UniProtKB=F2Z4N8	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Ensembl=ENSCAFG00000013179|UniProtKB=E2RPU9	Uncharacterized protein	ISS	11259498	PubMed	PTHR24229:SF11	NOCICEPTIN RECEPTOR
P00012	Cadherin signaling pathway	P00475	Frizzled	MONDO|Ensembl=ENSMODG00000006737|UniProtKB=F7CDC6	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF90	FRIZZLED-8
P00053	T cell activation	P01311	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	HUMAN|HGNC=465|UniProtKB=Q16671	Anti-Muellerian hormone type-2 receptor	TAS	9395284	PubMed	PTHR23255:SF49	ANTI-MUELLERIAN HORMONE TYPE-2 RECEPTOR
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	IDA	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=3784|UniProtKB=P61265	Syntaxin-1B	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	XENTR|Xenbase=XB-GENE-1010483|UniProtKB=F7AF72	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	HUMAN|HGNC=12372|UniProtKB=P01222	Thyrotropin subunit beta	ISS	15927770	PubMed	PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P00010	B cell activation	P00384	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	IDA	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	TAS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	HUMAN|HGNC=3023|UniProtKB=P14416	D(2) dopamine receptor	IDA	2137198	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00009	Axon guidance mediated by netrin	P00363	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00552	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00629	PP2A	RAT|RGD=620907|UniProtKB=Q5XI34	Protein Ppp2r1a	ISS	11994459	PubMed	PTHR10648:SF2	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 65 KDA REGULATORY SUBUNIT A ALPHA ISOFORM
P00034	Integrin signalling pathway	P00907	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	HUMAN|HGNC=4574|UniProtKB=P48058	Glutamate receptor 4	ISS	12871085	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P04397	p53 pathway by glucose deprivation	P04641	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	TAKRU|Ensembl=ENSTRUG00000016241|UniProtKB=H2UX35	Protein kinase C	ISS	11880265	PubMed	PTHR24356:SF305	PROTEIN KINASE C
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00059	p53 pathway	P04628	14-3-3	HUMAN|HGNC=10773|UniProtKB=P31947	14-3-3 protein sigma	ISS	10407019	PubMed	PTHR18860:SF14	14-3-3 PROTEIN SIGMA
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	IDA	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00568	PKC	DANRE|ZFIN=ZDB-GENE-030131-6503|UniProtKB=Q7ZUC5	Protein kinase C delta type	ISS	11880265	PubMed	PTHR24356:SF297	PROTEIN KINASE C DELTA TYPE
P00048	PI3 kinase pathway	P01199	Galpha	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05731	GABA-B receptor II signaling	P05755	Gbeta	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P02730	Asparagine and aspartate biosynthesis	P02853	Asparagine synthetase	YEAST|SGD=S000006349|UniProtKB=P49089	Asparagine synthetase [glutamine-hydrolyzing] 1	ISS			PTHR11772:SF2	ASPARAGINE SYNTHETASE
P00047	PDGF signaling pathway	P01161	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00019	Endothelin signaling pathway	P00590	IP3 R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00059	p53 pathway	P04635	Sumo-1 ligase	HUMAN|HGNC=12502|UniProtKB=P63165	Small ubiquitin-related modifier 1	ISS			PTHR10562:SF52	SMALL UBIQUITIN-RELATED MODIFIER 1
P00005	Angiogenesis	P00189	Fzd	MOUSE|MGI=MGI=108476|UniProtKB=Q61086	Frizzled-3	ISS	12549854	PubMed	PTHR11309:SF22	FRIZZLED-3
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	ISS	11956331	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P06587	Nicotine pharmacodynamics pathway	P06614	TH	RAT|RGD=3853|UniProtKB=P04177	Tyrosine 3-monooxygenase	RCA	12480184	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	HUMAN|HGNC=4599|UniProtKB=Q14831	Metabotropic glutamate receptor 7	IDA			PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00018	EGF receptor signaling pathway	P00539	14-3-3	HUMAN|HGNC=12855|UniProtKB=P63104	14-3-3 protein zeta/delta	ISS	92283271	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MACMU|Ensembl=ENSMMUG00000017683|UniProtKB=F6UA63	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00021	FGF signaling pathway	P00634	MEKK1-5	BOVIN|Ensembl=ENSBTAG00000009065|UniProtKB=F1MXH6	Uncharacterized protein	ISS	12697749	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00865	Shc	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	ISS	95096035	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	HUMAN|HGNC=1392|UniProtKB=Q15878	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	11976940	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00045	Notch signaling pathway	P01110	Presenilin	CANLF|Gene=PSEN1|UniProtKB=Q6RH31	Presenilin-1	ISS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00047	PDGF signaling pathway	P01168	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	1171954	gi	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00052	TGF-beta signaling pathway	P01275	P38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01214	CHIP	RAT|RGD=1306167|UniProtKB=D4A4T0	Protein Stub1	ISS	12150907	PubMed	PTHR44284:SF1	E3 UBIQUITIN-PROTEIN LIGASE CHIP
P00010	B cell activation	P00396	CD45	PANTR|Ensembl=ENSPTRG00000001817|UniProtKB=H2Q0U9	Uncharacterized protein	ISS	8940015	PubMed	PTHR19134:SF284	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C
P00021	FGF signaling pathway	P00642	MEK1-2	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00561	STAT	PANTR|Ensembl=ENSPTRG00000009199|UniProtKB=H2QD19	Signal transducer and activator of transcription	ISS	8732682	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	DROME|FlyBase=FBgn0010215|UniProtKB=P35220	Catenin alpha	TAS	9362521	PubMed	PTHR18914:SF9	CATENIN ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	MOUSE|MGI=MGI=1914007|UniProtKB=Q6P6J0	tRNA-specific adenosine deaminase 2	ISS			PTHR11079:SF92	TRNA-SPECIFIC ADENOSINE DEAMINASE 2
P00059	p53 pathway	G04703	Apaf	BOVIN|Ensembl=ENSBTAG00000021661|UniProtKB=F1MUW4	Apoptotic protease-activating factor 1	ISS	10364241	PubMed	PTHR22845:SF5	APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000009085|UniProtKB=H2RDQ2	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00060	Ubiquitin proteasome pathway	P01491	E2	HUMAN|HGNC=12477|UniProtKB=P51965	Ubiquitin-conjugating enzyme E2 E1	ISS			PTHR24068:SF70	UBIQUITIN-CONJUGATING ENZYME E2 E1
P00048	PI3 kinase pathway	P01192	p110	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04393	Ras Pathway	P04558	p38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00370	NFkappaB	MACMU|Ensembl=ENSMMUG00000002990|UniProtKB=F7GVV0	Uncharacterized protein	ISS	12574369	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MACMU|Ensembl=ENSMMUG00000004886|UniProtKB=F7AGT9	Uncharacterized protein	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	HUMAN|HGNC=5974|UniProtKB=P78552	Interleukin-13 receptor subunit alpha-1	IPI	8910586	PubMed	PTHR23036:SF89	INTERLEUKIN-13 RECEPTOR SUBUNIT ALPHA-1
P00049	Parkinson disease	P01211	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01443	Phospholipase C	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05730	Endogenous cannabinoid signaling	P05746	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00034	Integrin signalling pathway	P00944	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g210933|UniProtKB=A7SEA7	Predicted protein	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CHICK|Ensembl=ENSGALG00000015835|UniProtKB=F1NZT2	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00828	Galphai	EMENI|EnsemblGenome=CADANIAG00002024|UniProtKB=Q00743	Guanine nucleotide-binding protein subunit alpha	ISS			PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Ensembl=ENSCAFG00000009203|UniProtKB=F1PVZ1	Muscarinic acetylcholine receptor	ISS	10069496	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04398	p53 pathway feedback loops 2	P04665	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00017	DNA replication	P00527	Histones	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g227545|UniProtKB=A7SVW3	Predicted protein	ISS	12413958	PubMed	PTHR11426:SF110	SUBFAMILY NOT NAMED
P06216	SCW signaling pathway	P06327	TLD	DROME|FlyBase=FBgn0003719|UniProtKB=P25723	Dorsal-ventral patterning protein tolloid	IDA	9759503	PubMed	PTHR43978:SF2	DORSAL-VENTRAL PATTERNING PROTEIN TOLLOID-RELATED
P00006	Apoptosis signaling pathway	P00271	Bax	RAT|RGD=2192|UniProtKB=Q63690	Apoptosis regulator BAX	ISS	8358790	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	RCA	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PLAF7|EnsemblGenome=PFL2215w|UniProtKB=Q8I4X0	Actin-1	IDA			PTHR11937:SF155	ACTIN-5C-RELATED
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	HUMAN|HGNC=4579|UniProtKB=P39086	Glutamate receptor ionotropic, kainate 1	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=1305941|UniProtKB=F1M324	Phosphoinositide phospholipase C	ISS			PTHR10336:SF84	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	IDA	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00570	PKA	DICDI|dictyBase=DDB_G0283907|UniProtKB=P34099	cAMP-dependent protein kinase catalytic subunit	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P02763	Peptidoglycan biosynthesis	P03087	Glutamate racemase	STRCO|Gene=CAC14386|UniProtKB=Q9EX22	Putative glutamate racemase	ISS			PTHR21198:SF2	GLUTAMATE RACEMASE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00648	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00005	Angiogenesis	P00203	Erk	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	TAKRU|Ensembl=ENSTRUG00000016241|UniProtKB=H2UX35	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF305	PROTEIN KINASE C
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	15572354	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00029	Huntington disease	P00780	Microtubule	CANLF|Ensembl=ENSCAFG00000019807|UniProtKB=F2Z4P1	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00049	Parkinson disease	P01227	20S proteasome	MONDO|Ensembl=ENSMODG00000005573|UniProtKB=F7F3A6	Proteasome subunit beta type	ISS	12859888	PubMed	PTHR11599:SF59	PROTEASOME SUBUNIT BETA TYPE-1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	PANTR|Ensembl=ENSPTRG00000003207|UniProtKB=H2Q2Y0	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P02738	De novo purine biosynthesis	P02894	IMP cyclohydrolase	BOVIN|Ensembl=ENSBTAG00000019274|UniProtKB=Q0VCK0	Bifunctional purine biosynthesis protein PURH	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P00044	Nicotinic acetylcholine receptor signaling pathway	P01087	CAT	BOVIN|Ensembl=ENSBTAG00000016814|UniProtKB=F1MLQ5	Uncharacterized protein	ISS	97225904	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	3755548	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00049	Parkinson disease	P01242	Casein kinase I	RAT|RGD=621407|UniProtKB=Q62762	Casein kinase I isoform gamma-2	IDA	11437445	PubMed	PTHR11909:SF157	CASEIN KINASE I ISOFORM GAMMA-2
P00034	Integrin signalling pathway	P00924	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IPI	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00029	Huntington disease	P00775	Rac	CANAL|CGD=CAL0000192612|UniProtKB=P0CY33	Cell division control protein 42 homolog	TAS			PTHR24072:SF192	CDC42 HOMOLOG
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00030	Hypoxia response via HIF activation	P00817	TOR	RAT|RGD=68371|UniProtKB=P42346	Serine/threonine-protein kinase mTOR	TAS	14526383	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00053	T cell activation	P01315	Calcineurin	CHICK|Ensembl=ENSGALG00000005243|UniProtKB=E1C2T7	Serine/threonine-protein phosphatase	ISS	12015605	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00024	Glycolysis	P00680	Phosphoglyceromutase	YEAST|SGD=S000005417|UniProtKB=Q12326	Phosphoglycerate mutase 3	ISS	97313270	PubMed	PTHR11931:SF9	PHOSPHOGLYCERATE MUTASE 2-RELATED
P00018	EGF receptor signaling pathway	P00547	PP2A	ORNAN|Ensembl=ENSOANG00000005732|UniProtKB=F6X0X1	Uncharacterized protein	ISS	8576224	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PANTR|Ensembl=ENSPTRG00000018890|UniProtKB=Q5R1X3	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	RCA	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04393	Ras Pathway	P04570	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02775	Salvage pyrimidine ribonucleotides	P03149	Cytidine kinase	ORYSJ|EnsemblGenome=OS02G0708200|UniProtKB=Q6YV21	Os02g0708200 protein	ISS			PTHR10285:SF122	URIDINE-CYTIDINE KINASE C
P00053	T cell activation	P01300	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01318	PKC-theta	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01199	Galpha	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00029	Huntington disease	P00780	Microtubule	PRIPA|Gene=PPA21757|UniProtKB=H3FHL0	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00036	Interleukin signaling pathway	P00990	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00020	FAS signaling pathway	P00602	DAXX	MACMU|Ensembl=ENSMMUG00000004287|UniProtKB=F6ZLZ0	Uncharacterized protein	ISS	9215629	PubMed	PTHR12766:SF7	DEATH DOMAIN-ASSOCIATED PROTEIN 6
P00021	FGF signaling pathway	P00648	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06831	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	RCA	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00053	T cell activation	P01332	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P06959	CCKR signaling map	P07153	RSK1/2	HUMAN|HGNC=10432|UniProtKB=P51812	Ribosomal protein S6 kinase alpha-3	RCA	18813292	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00054	Toll receptor signaling pathway	P01356	ERK2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	HUMAN|HGNC=4232|UniProtKB=P39905	Glial cell line-derived neurotrophic factor	TAS	10779363	PubMed	PTHR12173:SF1	GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	MOUSE|MGI=MGI=105062|UniProtKB=Q8K592	Anti-Muellerian hormone type-2 receptor	TAS	9395284	PubMed	PTHR23255:SF49	ANTI-MUELLERIAN HORMONE TYPE-2 RECEPTOR
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	10747026	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	MACMU|Ensembl=ENSMMUG00000003842|UniProtKB=F7HAF3	Phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF32	CYTOSOLIC PHOSPHOLIPASE A2 BETA
P02775	Salvage pyrimidine ribonucleotides	P03155	Cytosine deaminase	BRADU|Gene=BAC52761|UniProtKB=Q89DE3	tRNA-specific adenosine deaminase	ISS			PTHR11079:SF149	TRNA-SPECIFIC ADENOSINE DEAMINASE
P00010	B cell activation	P00384	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IDA	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MONDO|Ensembl=ENSMODG00000023470|UniProtKB=F6T6U1	Uncharacterized protein	ISS	12441358	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00018	EGF receptor signaling pathway	P00547	PP2A	CANLF|Ensembl=ENSCAFG00000014047|UniProtKB=F1PV54	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06744	PPARalpha/gamma	MOUSE|MGI=MGI=104740|UniProtKB=P23204	Peroxisome proliferator-activated receptor alpha	RCA			PTHR24082:SF197	PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MONDO|Ensembl=ENSMODG00000025248|UniProtKB=F7F5X1	Uncharacterized protein	ISS	99084794	PubMed	PTHR24070:SF186	GTPASE KRAS
P00047	PDGF signaling pathway	P01140	ELK	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	11151091	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P02746	Heme biosynthesis	P02979	porphobilinogen synthase	METAC|EnsemblGenome=MA_0578|UniProtKB=Q8TT59	Delta-aminolevulinic acid dehydratase	ISS			PTHR11458:SF0	DELTA-AMINOLEVULINIC ACID DEHYDRATASE
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	NEUCR|EnsemblGenome=EFNCRG00000009356|UniProtKB=Q7S275	Aldehyde dehydrogenase	IC			PTHR11699:SF263	SUBFAMILY NOT NAMED
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CANLF|Ensembl=ENSCAFG00000013148|UniProtKB=Q5R1P3	Glutamate receptor ionotropic, NMDA 2B	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00048	PI3 kinase pathway	P01196	PDK1	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P02755	Methylmalonyl pathway	P03033	Propionyl-CoA carboxylase	PANTR|Ensembl=ENSPTRG00000015431|UniProtKB=H2QNF5	Propionyl CoA carboxylase, beta polypeptide	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00047	PDGF signaling pathway	P01142	p90RSK	MACMU|Ensembl=ENSMMUG00000005483|UniProtKB=F7G271	Uncharacterized protein	ISS	15116068	PubMed	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00047	PDGF signaling pathway	P01160	IP3 receptor	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00021	FGF signaling pathway	P00641	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00029	Huntington disease	P00780	Microtubule	BATDJ|Gene=BATDEDRAFT_37213|UniProtKB=F4P7H8	Alpha-Beta tubulin	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IDA	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00029	Huntington disease	P00786	ARF	DAPPU|EnsemblGenome=DAPPUDRAFT_309391|UniProtKB=E9HCC9	Putative uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00056	VEGF signaling pathway	P01411	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00012	Cadherin signaling pathway	P00474	Wnt	RAT|RGD=1308057|UniProtKB=F1M077	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P00034	Integrin signalling pathway	P00951	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00034	Integrin signalling pathway	P00924	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	MACMU|Ensembl=ENSMMUG00000010678|UniProtKB=F7AXI7	Uncharacterized protein	ISS	3768139	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01471	alpha-catenin	ANOGA|EnsemblGenome=AGAP003424|UniProtKB=Q7QDI9	AGAP003424-PA	ISS	1768802	PubMed	PTHR18914:SF9	CATENIN ALPHA
P00021	FGF signaling pathway	P00632	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IGI	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BOVIN|Gene=ACTG2|UniProtKB=Q5E9B5	Actin, gamma-enteric smooth muscle	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00034	Integrin signalling pathway	P00931	Integrin beta	MACMU|Ensembl=ENSMMUG00000003289|UniProtKB=F7FG54	Integrin beta	ISS	386150	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04395	Vasopressin synthesis	P04596	Endo Peptidase	MOUSE|MGI=MGI=1270863|UniProtKB=Q9QUR6	Prolyl endopeptidase	IC	9695945	PubMed	PTHR42881:SF2	PROLYL ENDOPEPTIDASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00035	Interferon-gamma signaling pathway	P00961	STAT1	TAKRU|Ensembl=ENSTRUG00000000102|UniProtKB=H2RJA9	Signal transducer and activator of transcription	ISS	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MOUSE|MGI=MGI=2183924|UniProtKB=Q8K3H5	Myosin-IIIa	ISS			PTHR13140:SF387	MYOSIN-IIIA
P00047	PDGF signaling pathway	P01160	IP3 receptor	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00644	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00546	GAP	HUMAN|HGNC=35202|UniProtKB=C9J798	Ras GTPase-activating protein 4B	ISS	6635197	gi	PTHR10194:SF4	RAS GTPASE-ACTIVATING PROTEIN 4-RELATED
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MOUSE|MGI=MGI=108476|UniProtKB=Q61086	Frizzled-3	TAS	12549854	PubMed	PTHR11309:SF22	FRIZZLED-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IDA	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	TAS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00052	TGF-beta signaling pathway	P01286	TGFbeta	CHICK|Ensembl=ENSGALG00000003161|UniProtKB=Q98950	CVg1 protein	TAS	9759503	PubMed	PTHR11848:SF151	EMBRYONIC GROWTH/DIFFERENTIATION FACTOR 1
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_125401|UniProtKB=C3ZTX6	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	TAS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MACMU|Ensembl=ENSMMUG00000009771|UniProtKB=F6ZHU6	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF681	MYOSIN-4
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00054	Toll receptor signaling pathway	G01550	Gene trancription	RAT|RGD=2865|UniProtKB=P70499	Interferon beta	ISS			PTHR11691:SF43	INTERFERON BETA
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00056	VEGF signaling pathway	P01417	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	HUMAN|HGNC=4580|UniProtKB=Q13002	Glutamate receptor ionotropic, kainate 2	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P05915	Opioid proenkephalin pathway	P05987	peptide F	RAT|RGD=68946|UniProtKB=P04094	Proenkephalin-A	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95774|UniProtKB=Q8CGK7	Guanine nucleotide-binding protein G(olf) subunit alpha	IC	6309844	PubMed	PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=106672|UniProtKB=P33146	Cadherin-15	IDA	8120095	PubMed	PTHR24027:SF300	CADHERIN-15
P00056	VEGF signaling pathway	P01401	HIF-1	CANLF|Ensembl=ENSCAFG00000015718|UniProtKB=F1PZ54	Uncharacterized protein	ISS	9606183	PubMed	PTHR23043:SF7	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA
P00005	Angiogenesis	P00253	Axin	RAT|RGD=69259|UniProtKB=O70240	Axin-2	ISS	9554852	PubMed	PTHR10845:SF103	AXIN-2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=13251|UniProtKB=Q9UJ99	Cadherin-22	IDA	8120095	PubMed	PTHR24027:SF311	CADHERIN-22
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00046	Oxidative stress response	P01135	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00007	Axon guidance mediated by semaphorins	P00331	PAK	MOUSE|MGI=MGI=1339975|UniProtKB=O88643	Serine/threonine-protein kinase PAK 1	IDA	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00004	Alzheimer disease-presenilin pathway	P00177	Nectin 1alpha C-terminal fragment	RAT|RGD=620791|UniProtKB=F1LNP8	Poliovirus receptor-related 1	ISS	12376527	PubMed	PTHR23277:SF69	NECTIN-1
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	MOUSE|MGI=MGI=109284|UniProtKB=Q61144	Presenilin-2	IDA	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P05912	Dopamine receptor mediated signaling pathway	P05963	MAO	PANTR|Ensembl=ENSPTRG00000021816|UniProtKB=H2QYH5	Amine oxidase [flavin-containing]	ISS	8602220	PubMed	PTHR43563:SF3	AMINE OXIDASE  FLAVIN-CONTAINING  A
P02723	Adenine and hypoxanthine salvage pathway	P02807	Deoxyadenosine deaminase	MOUSE|MGI=MGI=87916|UniProtKB=P03958	Adenosine deaminase	ISS			PTHR11409:SF43	ADENOSINE DEAMINASE
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05918	p38 MAPK pathway	P06027	CREB	XENTR|Xenbase=XB-GENE-945015|UniProtKB=F6QA46	Uncharacterized protein	ISS	11752053	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	RAT|RGD=69430|UniProtKB=P32851	Syntaxin-1A	ISS	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TRIAD|EnsemblGenome=TriadG35956|UniProtKB=Q7YTV5	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00007	Axon guidance mediated by semaphorins	P00340	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04496	Mdm2	RAT|RGD=1305332|UniProtKB=A0A0G2JVC1	Protein Mdm2	ISS	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IDA	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	HUMAN|HGNC=1965|UniProtKB=Q07001	Acetylcholine receptor subunit delta	IC	85203892	PubMed	PTHR18945:SF61	ACETYLCHOLINE RECEPTOR SUBUNIT DELTA
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00054	Toll receptor signaling pathway	P01365	TAB1	MACMU|Ensembl=ENSMMUG00000012103|UniProtKB=F7H8X1	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform alpha	ISS	8638164	PubMed	PTHR13832:SF533	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00023	General transcription regulation	P00661	TTF2	PANTR|Ensembl=ENSPTRG00000005395|UniProtKB=H2Q6S6	MTERF domain containing 3	ISS	604718	OMIM	PTHR15437:SF1	TRANSCRIPTION TERMINATION FACTOR 2, MITOCHONDRIAL
P00048	PI3 kinase pathway	P01192	p110	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01208	Hsp70	RAT|RGD=2843|UniProtKB=P06761	78 kDa glucose-regulated protein	IDA	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MOUSE|MGI=MGI=1921305|UniProtKB=Q8K4S1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	12176394	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00034	Integrin signalling pathway	P00936	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	IPI	1171954	gi	PTHR10048:SF14	PI-3 KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00048	PI3 kinase pathway	P01199	Galpha	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00547	PP2A	DANRE|ZFIN=ZDB-GENE-040426-2487|UniProtKB=Q803G3	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	BOVIN|Ensembl=ENSBTAG00000047719|UniProtKB=Q95136	D(1A) dopamine receptor	ISS	9700720	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IDA	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00190	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	227170	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MOUSE|MGI=MGI=95823|UniProtKB=Q03391	Glutamate receptor ionotropic, NMDA 2D	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00012	Cadherin signaling pathway	P00474	Wnt	BOVIN|Ensembl=ENSBTAG00000008097|UniProtKB=A4D7S0	Protein Wnt-2	ISS	8717036	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P05730	Endogenous cannabinoid signaling	P05746	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00017	DNA replication	P00527	Histones	CHICK|Ensembl=ENSGALG00000002286|UniProtKB=P84247	Histone H3.3	ISS	12413958	PubMed	PTHR11426:SF179	HISTONE H3.3
P00047	PDGF signaling pathway	P01160	IP3 receptor	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00058	mRNA splicing	P01473	U6	YEAST|SGD=S000006382|UniProtKB=P20053	U4/U6 small nuclear ribonucleoprotein PRP4	ISS	97313271	PubMed	PTHR19846:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP4
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00038	JAK/STAT signaling pathway	P01027	STAT	MONDO|Ensembl=ENSMODG00000014816|UniProtKB=F7CHH2	Signal transducer and activator of transcription	ISS	14662325	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00052	TGF-beta signaling pathway	P01279	Smurfs	DROME|FlyBase=FBgn0029006|UniProtKB=Q9V853	E3 ubiquitin-protein ligase Smurf1	TAS	11252892	PubMed	PTHR11254:SF395	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00047	PDGF signaling pathway	P01171	PLCgamma	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00021	FGF signaling pathway	P00636	FGFR1-4	MOUSE|MGI=MGI=95523|UniProtKB=P21803	Fibroblast growth factor receptor 2	IPI	14507786	PubMed	PTHR24416:SF130	FIBROBLAST GROWTH FACTOR RECEPTOR 2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00056	VEGF signaling pathway	P01417	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00996	STAT	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	14755057	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01275	P38	DROME|FlyBase=FBgn0015765|UniProtKB=O62618	Mitogen-activated protein kinase 14A	TAS	10514528	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00053	T cell activation	P01332	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01188	Gbetagamma	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00047	PDGF signaling pathway	P01143	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00236	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	PANTR|Ensembl=ENSPTRG00000020202|UniProtKB=H2QW34	Uncharacterized protein	ISS	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PHYPA|Gene=PHYPADRAFT_172686|UniProtKB=A9TYG6	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00056	VEGF signaling pathway	P01415	MAPKAPK2/3	RAT|RGD=1304980|UniProtKB=Q66H84	MAP kinase-activated protein kinase 3	ISS	11335727	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00557	PI3K	CHICK|Gene_ORFName=RCJMB04_28f9|UniProtKB=Q5ZIB8	Phosphoinositide 3-kinase regulatory subunit 5	ISS			PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00005	Angiogenesis	P00256	PLC-gamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	YEAST|SGD=S000001587|UniProtKB=P14742	Glutamine--fructose-6-phosphate aminotransferase [isomerizing]	ISS			PTHR10937:SF0	GH12731P-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00013	Cell cycle	P00483	Cyclin E	RAT|RGD=2294|UniProtKB=P39949	G1/S-specific cyclin-E1	ISS	6671698	gi	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=19218|UniProtKB=Q86YW0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1	ISS	7822322	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P00029	Huntington disease	P00787	MAPKK4	MACMU|Ensembl=ENSMMUG00000019842|UniProtKB=F7FU91	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CHICK|Ensembl=ENSGALG00000006638|UniProtKB=R4GGL9	Uncharacterized protein	ISS	1648176	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CHICK|Ensembl=ENSGALG00000021020|UniProtKB=F1NN71	Uncharacterized protein	IDA			PTHR24241:SF61	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	DANRE|ZFIN=ZDB-GENE-020125-4|UniProtKB=F1QKT1	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	SCHPO|PomBase=SPBC32H8.07|UniProtKB=Q10282	Guanine nucleotide-binding protein subunit beta	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	TAS	12040174	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	DROME|FlyBase=FBgn0011836|UniProtKB=Q24325	Transcription initiation factor TFIID subunit 2	ISS			PTHR15137:SF9	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=3026|UniProtKB=P21918	D(1B) dopamine receptor	IDA			PTHR43893:SF8	D 1B  DOPAMINE RECEPTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	RAT|RGD=620023|UniProtKB=P10980	Muscarinic acetylcholine receptor M2	IDA			PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IC	89186920	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00053	T cell activation	P01312	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05915	Opioid proenkephalin pathway	P05994	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00059	p53 pathway	P04620	TRAF	MOUSE|MGI=MGI=101835|UniProtKB=P39429	TNF receptor-associated factor 2	ISS			PTHR10131:SF21	TNF RECEPTOR-ASSOCIATED FACTOR 2
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04393	Ras Pathway	P04542	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00049	Parkinson disease	P01234	GRK	TAKRU|Ensembl=ENSTRUG00000018612|UniProtKB=H2VEM3	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF18	PROTEIN-SERINE/THREONINE KINASE
P00057	Wnt signaling pathway	P01456	beta-arrestin	DROME|FlyBase=FBgn0040206|UniProtKB=Q9V393	Kurtz arrestin	IDA	4757780	gi	PTHR11792:SF17	KURTZ ARRESTIN
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00049	Parkinson disease	P01238	14-3-3	MOUSE|MGI=MGI=108109|UniProtKB=P61982	14-3-3 protein gamma	ISS	99360936	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00005	Angiogenesis	P00238	Ras	CAEBR|Gene=CBG06092|UniProtKB=A8X0X5	Protein CBR-LET-60	ISS			PTHR24070:SF385	GTPASE HRAS
P00012	Cadherin signaling pathway	P00467	alpha-catenin	TAKRU|Ensembl=ENSTRUG00000002863|UniProtKB=H2S2N9	Uncharacterized protein	ISS	1638632	PubMed	PTHR18914:SF29	CATENIN ALPHA-2
P00005	Angiogenesis	P00245	Rac	CANLF|Ensembl=ENSCAFG00000009147|UniProtKB=A4GT58	Cdc42 GTPase-activating protein	ISS	14724572	PubMed	PTHR23176:SF28	RHO GTPASE-ACTIVATING PROTEIN 1
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CAEBR|Gene=CBG02167|UniProtKB=A8WS37	Protein CBG02167	ISS	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P04393	Ras Pathway	P04568	MKK3/6	MONDO|Ensembl=ENSMODG00000006330|UniProtKB=F7AGV5	Uncharacterized protein	RCA			PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P00034	Integrin signalling pathway	P00914	Filamin	CANLF|Ensembl=ENSCAFG00000019521|UniProtKB=F1PWW0	Uncharacterized protein	ISS	9722563	PubMed	PTHR43998:SF6	FILAMIN-A
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04407	K+ channel	RAT|RGD=61997|UniProtKB=O54912	Potassium channel subfamily K member 3	ISS	15282272	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P04393	Ras Pathway	P04542	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00629	PP2A	RAT|RGD=1304764|UniProtKB=Q4QQT4	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform	ISS			PTHR10648:SF9	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 65 KDA REGULATORY SUBUNIT A BETA ISOFORM
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8709|UniProtKB=Q9Y5G2	Protocadherin gamma-B2	IDA	8120095	PubMed	PTHR24028:SF144	PROTOCADHERIN GAMMA-B2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	CHICK|Ensembl=ENSGALG00000007039|UniProtKB=F1NG99	Tyrosine-protein kinase receptor	ISS	11182407	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	CRYNJ|EnsemblGenome=CNA04370|UniProtKB=P0CN84	Glutamine synthetase	ISS			PTHR20852:SF57	GLUTAMINE SYNTHETASE 2 CYTOPLASMIC
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CAEEL|WormBase=WBGene00004037|UniProtKB=Q9XWB7	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF9	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	10074940	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	TAKRU|Ensembl=ENSTRUG00000011517|UniProtKB=H2TWL9	Uncharacterized protein (Fragment)	ISS	10331083	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00056	VEGF signaling pathway	P01423	p38MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	PANTR|Ensembl=ENSPTRG00000017236|UniProtKB=H2QRH6	Uncharacterized protein	ISS	12356903	PubMed	PTHR10373:SF33	TRANSCRIPTION FACTOR 7
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00029	Huntington disease	P00807	Actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	IDA	14684598	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00046	Oxidative stress response	P01135	p38	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	TAS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00036	Interleukin signaling pathway	P00983	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CAEEL|WormBase=WBGene00003774|UniProtKB=G5EGQ9	NMDA class glutamate Receptor	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	MACMU|Ensembl=ENSMMUG00000010173|UniProtKB=F7AGU8	Presenilin	ISS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00018	EGF receptor signaling pathway	P00564	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02771	Pyrimidine Metabolism	P03131	5'-Nucleotidase	MOUSE|MGI=MGI=99782|UniProtKB=Q61503	5'-nucleotidase	IDA	3219501	gi	PTHR11575:SF25	5'-NUCLEOTIDASE
P04373	5HT1 type receptor mediated signaling pathway	P04407	K+ channel	BOVIN|Ensembl=ENSBTAG00000018193|UniProtKB=E1BHX8	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MONDO|Ensembl=ENSMODG00000020204|UniProtKB=F6SED9	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00029	Huntington disease	P00811	Arp2/3 complex	ORNAN|Ensembl=ENSOANG00000000999|UniProtKB=F6WN02	Actin-related protein 2/3 complex subunit 5	ISS	9230079	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00034	Integrin signalling pathway	P00907	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	ARATH|TAIR=AT5G07880|UniProtKB=Q9SD96	SNAP25 homologous protein SNAP29	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00057	Wnt signaling pathway	P01428	Frizzled	RAT|RGD=61916|UniProtKB=Q08463	Frizzled-1	IDA	11212302	PubMed	PTHR11309:SF81	FRIZZLED-1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CAEEL|WormBase=WBGene00000066|UniProtKB=P10986	Actin-4	IDA	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00053	T cell activation	P01307	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00005	Angiogenesis	P00203	Erk	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2846|UniProtKB=P28564	5-hydroxytryptamine receptor 1B	IDA	12181435	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=7600|UniProtKB=O00160	Unconventional myosin-If	IC			PTHR13140:SF288	UNCONVENTIONAL MYOSIN-IF
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00057	Wnt signaling pathway	P01432	Beta-Catenin	PANTR|Ensembl=ENSPTRG00000023062|UniProtKB=H2R2U1	Catenin (Cadherin-associated protein), beta 1, 88kDa	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MACMU|Ensembl=ENSMMUG00000014262|UniProtKB=F7BYS8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00023	General transcription regulation	P00658	TBP-associated factors	DROME|FlyBase=FBgn0011290|UniProtKB=P49905	Transcription initiation factor TFIID subunit 12	ISS			PTHR12264:SF21	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00877	MLCK	MOUSE|MGI=MGI=2139434|UniProtKB=Q8VCR8	Myosin light chain kinase 2, skeletal/cardiac muscle	ISS	11157482	PubMed	PTHR45210:SF1	MYOSIN LIGHT CHAIN KINASE 2, SKELETAL/CARDIAC MUSCLE
P00004	Alzheimer disease-presenilin pathway	P00118	E-cadherin	PANTR|Ensembl=ENSPTRG00000008270|UniProtKB=H2QBE5	Uncharacterized protein	ISS	12834808	PubMed	PTHR24027:SF319	CADHERIN-1
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MACMU|Ensembl=ENSMMUG00000014227|UniProtKB=P56490	Muscarinic acetylcholine receptor M5	TAS	11166329	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00019	Endothelin signaling pathway	P00568	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05915	Opioid proenkephalin pathway	P05994	G-protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00010	B cell activation	P00398	IP3R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00045	Notch signaling pathway	P01107	Fringe	CHICK|Gene=RFNG|UniProtKB=O12972	Beta-1,3-N-acetylglucosaminyltransferase radical fringe	IGI	9121551	PubMed	PTHR10811:SF1	BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE RADICAL FRINGE
P00006	Apoptosis signaling pathway	P00269	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	DROME|FlyBase=FBgn0010453|UniProtKB=P40589	Protein Wnt-4	TAS	8717036	PubMed	PTHR12027:SF102	PROTEIN WNT-4
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	CHICK|Gene=CHRM4|UniProtKB=P17200	Muscarinic acetylcholine receptor M4	TAS	10069496	PubMed	PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Ensembl=ENSGALG00000009844|UniProtKB=P68034	Actin, alpha cardiac muscle 1	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00030	Hypoxia response via HIF activation	P00819	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00053	T cell activation	P01318	PKC-theta	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IGI	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00048	PI3 kinase pathway	P01182	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04393	Ras Pathway	P04548	ATF2	MONDO|Ensembl=ENSMODG00000009514|UniProtKB=F7EVK3	Uncharacterized protein	ISS	7875593	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00590	IP3 R	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	IGI	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04658	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00019	Endothelin signaling pathway	P00566	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00047	PDGF signaling pathway	P01167	Ets	RAT|RGD=1311991|UniProtKB=D3ZJW0	Protein Erf	ISS	15298723	PubMed	PTHR11849:SF31	ETS DOMAIN-CONTAINING TRANSCRIPTION FACTOR ERF
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	DEIRA|EnsemblGenome=DR_0035|UniProtKB=Q9RYB5	Adenylosuccinate synthetase	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00012	Cadherin signaling pathway	P00470	F-actin	BOVIN|Ensembl=ENSBTAG00000005714|UniProtKB=Q3ZC07	Actin, alpha cardiac muscle 1	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00053	T cell activation	P01294	NFAT	MACMU|Ensembl=ENSMMUG00000022596|UniProtKB=F6Z7T2	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF5	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 1
P00018	EGF receptor signaling pathway	P00561	STAT	PANTR|Ensembl=ENSPTRG00000009199|UniProtKB=H2QD19	Signal transducer and activator of transcription	ISS	7514531	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00055	Transcription regulation by bZIP transcription factor	P01386	TFIIEbeta	SCHPO|PomBase=SPCC1672.08c|UniProtKB=P79011	Transcription initiation factor IIE subunit beta	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P00047	PDGF signaling pathway	P01171	PLCgamma	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00049	Parkinson disease	P01211	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01202	p85	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00005	Angiogenesis	P00182	p38MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00548	RKIP	MACMU|Ensembl=ENSMMUG00000005098|UniProtKB=F5CI18	Phosphatidylethanolamine-binding protein	ISS	8037677	PubMed	PTHR11362:SF28	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P00050	Plasminogen activating cascade	P01257	tPA	PANTR|Ensembl=ENSPTRG00000020201|UniProtKB=H2QW33	Tissue-type plasminogen activator	ISS	4505861	gi	PTHR44617:SF1	TISSUE-TYPE PLASMINOGEN ACTIVATOR
P00005	Angiogenesis	P00208	MEKK1	RAT|RGD=620966|UniProtKB=Q62925	Mitogen-activated protein kinase kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CAEBR|Gene=CBG23090|UniProtKB=A8Y4R0	Protein CBG23090	ISS	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=619742|UniProtKB=F1MAH6	Protein Cdh11	ISS	8120095	PubMed	PTHR24027:SF85	CADHERIN-11
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	RAT|RGD=2035|UniProtKB=Q03343	Adenylate cyclase type 6	IGI	2491850	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00057	Wnt signaling pathway	P01457	GBeta	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00054	Toll receptor signaling pathway	G01550	Gene trancription	RAT|RGD=620349|UniProtKB=P35355	Prostaglandin G/H synthase 2	ISS	93357029	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00546	GAP	CANLF|Ensembl=ENSCAFG00000018592|UniProtKB=F1PIZ0	Uncharacterized protein	ISS	18587532	gi	PTHR10194:SF60	NEUROFIBROMIN
P00056	VEGF signaling pathway	P01417	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=19218|UniProtKB=Q86YW0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1	ISS	15611108	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00047	PDGF signaling pathway	P01173	STAT	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	IDA	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P06959	CCKR signaling map	P07037	PLCgamma1	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	RCA	7487955	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	MACMU|Ensembl=ENSMMUG00000028962|UniProtKB=F7EWG5	Uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF322	SUBFAMILY NOT NAMED
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00303	c-Jun	CHICK|Gene=JUN|UniProtKB=P18870	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00036	Interleukin signaling pathway	P00967	c-fos	MACMU|Ensembl=ENSMMUG00000010574|UniProtKB=A5A6H2	C-fos	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00021	FGF signaling pathway	P00633	Ras	BOVIN|Ensembl=ENSBTAG00000009778|UniProtKB=E1BMX0	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00147	TACE	CANLF|Ensembl=ENSCAFG00000003383|UniProtKB=F1PFZ9	Uncharacterized protein	ISS	12834808	PubMed	PTHR11905:SF171	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17
P00005	Angiogenesis	P00225	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	RCA			PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00029	Huntington disease	P00778	NMDA receptor	DROME|FlyBase=FBgn0010399|UniProtKB=Q24418	Glutamate [NMDA] receptor subunit 1	IDA	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BOVIN|Ensembl=ENSBTAG00000015364|UniProtKB=E1BEN9	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00848	Grb	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	10521483	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P05918	p38 MAPK pathway	P06039	MSK2	RAT|RGD=1307277|UniProtKB=D3ZSB7	Ribosomal protein S6 kinase	ISS	9792677	PubMed	PTHR24351:SF41	RIBOSOMAL PROTEIN S6 KINASE ALPHA-4
P05915	Opioid proenkephalin pathway	P05992	met-Enkephalin	XENTR|Xenbase=XB-GENE-942760|UniProtKB=F6Y5F6	Uncharacterized protein	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	DROME|FlyBase=FBgn0004168|UniProtKB=P28285	5-hydroxytryptamine receptor 2A	IDA			PTHR24247:SF117	5-HYDROXYTRYPTAMINE RECEPTOR 2A-RELATED
P00056	VEGF signaling pathway	P01411	Ras	DICDI|dictyBase=DDB_G0281385|UniProtKB=P32253	Ras-like protein rasC	ISS	8290260	PubMed	PTHR24070:SF251	RAS-LIKE PROTEIN RASC
P00019	Endothelin signaling pathway	P00572	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00036	Interleukin signaling pathway	P00981	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	TAS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05918	p38 MAPK pathway	P06021	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00006	Apoptosis signaling pathway	P00310	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IDA	7565716	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00054	Toll receptor signaling pathway	P01345	IKKalpha	CANLF|Ensembl=ENSCAFG00000009588|UniProtKB=E2RNA9	Uncharacterized protein	ISS	12235208	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P04393	Ras Pathway	P04558	p38	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P05731	GABA-B receptor II signaling	P05753	Ca channel	HUMAN|HGNC=1389|UniProtKB=Q00975	Voltage-dependent N-type calcium channel subunit alpha-1B	TAS	15079861	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	MOUSE|MGI=MGI=103296|UniProtKB=P97305	Nuclear factor of activated T-cells, cytoplasmic 3	ISS	12787506	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00049	Parkinson disease	P01211	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01327	Gads	HUMAN|HGNC=4563|UniProtKB=O75791	GRB2-related adapter protein 2	IPI	51702266	gi	PTHR24418:SF299	GRB2-RELATED ADAPTER PROTEIN 2
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00931	Integrin beta	XENTR|Xenbase=XB-GENE-1009964|UniProtKB=F6SRR1	Integrin beta (Fragment)	ISS	3487386	PubMed	PTHR10082:SF25	INTEGRIN BETA-3
P00045	Notch signaling pathway	P01120	NIcs	RAT|RGD=620761|UniProtKB=Q9R172	Neurogenic locus notch homolog protein 3	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TRIAD|EnsemblGenome=TriadG56111|UniProtKB=B3RX77	Non-muscle actin 6.2	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00036	Interleukin signaling pathway	P00983	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00521	Profilin	MACMU|Ensembl=ENSMMUG00000023337|UniProtKB=F7EGP4	Profilin	ISS			PTHR13936:SF15	PROFILIN-2
P00054	Toll receptor signaling pathway	P01360	IKKbeta	CANLF|Ensembl=ENSCAFG00000005526|UniProtKB=E2RKR0	Uncharacterized protein	ISS	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00056	VEGF signaling pathway	P01411	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IGI	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00013	Cell cycle	P00480	Proteasome	MONDO|Ensembl=ENSMODG00000002631|UniProtKB=F7FUB1	Uncharacterized protein	ISS	95275316	PubMed	PTHR10540:SF7	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7
P04393	Ras Pathway	P04568	MKK3/6	PANTR|Ensembl=ENSPTRG00000008895|UniProtKB=H2R497	Mitogen-activated protein kinase kinase 3	ISS	11279172	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06739	MEK1/2	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	RCA	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00029	Huntington disease	G01535	PIG3	ARATH|TAIR=AT3G56460|UniProtKB=Q9LXZ4	GroES-like zinc-binding alcohol dehydrogenase family protein	TAS			PTHR43677:SF4	QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2
P00056	VEGF signaling pathway	P01413	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	ISS	129387	gi	PTHR10048:SF14	PI-3 KINASE
P04393	Ras Pathway	P04559	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01182	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00070	VAT2	BOVIN|Gene=SLC18A2|UniProtKB=Q27963	Synaptic vesicular amine transporter	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00021	FGF signaling pathway	P00648	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02748	Isoleucine biosynthesis	P02995	Threonine dehydratase	PYRAE|EnsemblGenome=PAE2316|UniProtKB=Q8ZVF0	Threonine dehydratase (IlvA)	ISS			PTHR43419:SF8	THREONINE AMMONIA-LYASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	HUMAN|HGNC=5466|UniProtKB=P01344	Insulin-like growth factor II	ISS	4504609	gi	PTHR11454:SF10	INSULIN-LIKE GROWTH FACTOR II
P00055	Transcription regulation by bZIP transcription factor	P01392	TFIIH complex	PANTR|Ensembl=ENSPTRG00000017943|UniProtKB=P60027	General transcription factor IIH subunit 4	ISS			PTHR13152:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4
P00057	Wnt signaling pathway	P01451	Galpha	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	IDA	8457205	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00050	Plasminogen activating cascade	P01244	PAI-2	RAT|RGD=621823|UniProtKB=P29524	Plasminogen activator inhibitor 2 type A	ISS	11067431	gi	PTHR11461:SF61	PLASMINOGEN ACTIVATOR INHIBITOR 2
P00025	Hedgehog signaling pathway	P00692	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00059	p53 pathway	G04702	p53	DANRE|ZFIN=ZDB-GENE-030819-1|UniProtKB=E9QG65	Uncharacterized protein	TAS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00018	EGF receptor signaling pathway	P00565	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MONDO|Ensembl=ENSMODG00000000771|UniProtKB=F6SSS3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00046	Oxidative stress response	P01131	MKP5	RAT|RGD=620854|UniProtKB=O54838	Dual specificity protein phosphatase 5	TAS			PTHR10159:SF40	DUAL SPECIFICITY PROTEIN PHOSPHATASE 5
P00047	PDGF signaling pathway	P01161	Raf	CAEEL|WormBase=WBGene00003030|UniProtKB=Q07292	Raf homolog serine/threonine-protein kinase	ISS	125651	gi	PTHR44000:SF2	RAF HOMOLOG SERINE/THREONINE-PROTEIN KINASE PHL
P00024	Glycolysis	P00671	Phosphoglycerate kinase	MONDO|Ensembl=ENSMODG00000023304|UniProtKB=F6VB69	Phosphoglycerate kinase	ISS	79199779	PubMed	PTHR11406:SF0	PHOSPHOGLYCERATE KINASE
P02749	Leucine biosynthesis	P02999	2-Isopropylmalate synthase	DEIRA|EnsemblGenome=DR_1482|UniProtKB=Q9RUA9	2-isopropylmalate synthase	ISS			PTHR10277:SF9	2-ISOPROPYLMALATE SYNTHASE 1, CHLOROPLASTIC-RELATED
P00006	Apoptosis signaling pathway	P00318	PKCs	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IDA	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P02784	Tyrosine biosynthesis	P03213	Aromatic amino acid aminotransferase	ARATH|TAIR=AT4G23600|UniProtKB=Q9SUR6	Cystine lyase CORI3	ISS			PTHR11751:SF368	TYROSINE AMINOTRANSFERASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00046	Oxidative stress response	P01124	Myc	DANRE|ZFIN=ZDB-GENE-990415-162|UniProtKB=P52160	Transcriptional regulator Myc-A	TAS	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00877	MLCK	PANTR|Ensembl=ENSPTRG00000013361|UniProtKB=H2QK55	Uncharacterized protein	ISS	11157482	PubMed	PTHR45210:SF1	MYOSIN LIGHT CHAIN KINASE 2, SKELETAL/CARDIAC MUSCLE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00970	Interleukin	BOVIN|Gene=IL10|UniProtKB=P43480	Interleukin-10	ISS	8112615	PubMed	PTHR44875:SF1	INTERLEUKIN-10
P05734	Synaptic vesicle trafficking	P05774	NSF	CAEEL|WormBase=WBGene00003818|UniProtKB=Q94392	Vesicle-fusing ATPase	TAS	11348590	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	DROME|FlyBase=FBgn0010399|UniProtKB=Q24418	Glutamate [NMDA] receptor subunit 1	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00805	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IDA	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05918	p38 MAPK pathway	P06015	p38gamma	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P05730	Endogenous cannabinoid signaling	P05751	Galpha	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02918	dUTP pyrophosphatase	DROME|FlyBase=FBgn0250837|UniProtKB=Q9V3I1	BcDNA.LD08534	ISS			PTHR11241:SF0	BCDNA.LD08534
P00047	PDGF signaling pathway	P01150	PKC	YEAST|SGD=S000000201|UniProtKB=P24583	Protein kinase C-like 1	ISS	125549	gi	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00021	FGF signaling pathway	P00624	14-3-3	ARATH|TAIR=AT1G78300|UniProtKB=Q01525	14-3-3-like protein GF14 omega	ISS	10407019	PubMed	PTHR18860:SF26	14-3-3 FAMILY PROTEIN-RELATED
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000016727|UniProtKB=F6VCS5	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF1	CADHERIN-16
P04393	Ras Pathway	P04574	PLD	ARATH|TAIR=AT3G15730|UniProtKB=Q38882	Phospholipase D alpha 1	ISS			PTHR18896:SF109	PHOSPHOLIPASE D ALPHA 1-RELATED
P00047	PDGF signaling pathway	P01143	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	12657601	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05731	GABA-B receptor II signaling	P05754	Ggamma	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00012	Cadherin signaling pathway	P00474	Wnt	PANTR|Ensembl=ENSPTRG00000004892|UniProtKB=H2Q5U3	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00020	FAS signaling pathway	P00615	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00269	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00577	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IGI	1171954	gi	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=8154|UniProtKB=P41145	Kappa-type opioid receptor	IDA	11259487	PubMed	PTHR24229:SF1	KAPPA-TYPE OPIOID RECEPTOR
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00299	Caspase 8	MOUSE|MGI=MGI=1261423|UniProtKB=O89110	Caspase-8	ISS	11788820	PubMed	PTHR10454:SF162	CASPASE-8
P00053	T cell activation	P01331	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00029	Huntington disease	P00792	SEK-1	CAEEL|WormBase=WBGene00004758|UniProtKB=G5EDF7	Dual specificity mitogen-activated protein kinase kinase sek-1	TAS	11724916	PubMed	PTHR24361:SF607	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE SEK-1
P00054	Toll receptor signaling pathway	P01381	Ubc13	MACMU|Ensembl=ENSMMUG00000032326|UniProtKB=F7GIS4	Uncharacterized protein	ISS			PTHR43902:SF2	UBIQUITIN-CONJUGATING ENZYME E2 N
P02785	Valine biosynthesis	P03217	Dihydroxy isovalerate reductoisomerase	STRCO|EnsemblGenome=CAC01643|UniProtKB=Q9FBT8	Ketol-acid reductoisomerase 2	ISS			PTHR21371:SF1	KETOL-ACID REDUCTOISOMERASE, CHLOROPLASTIC
P00018	EGF receptor signaling pathway	P00554	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00148	Erb-B4 N-terminal fragment	RAT|RGD=620486|UniProtKB=Q62956	Receptor tyrosine-protein kinase erbB-4	IDA	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00624	14-3-3	HUMAN|HGNC=12854|UniProtKB=P27348	14-3-3 protein theta	IPI	7603573	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000005917|UniProtKB=F6QM53	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02752	Mannose metabolism	P03017	Mannose 6-P isomerase	ORYSJ|EnsemblGenome=OS01G0127900|UniProtKB=Q9FTR6	Mannose-6-phosphate isomerase	ISS	12447438	PubMed	PTHR10309:SF0	MANNOSE-6-PHOSPHATE ISOMERASE
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	PANTR|Ensembl=ENSPTRG00000013189|UniProtKB=H2QJV1	Uncharacterized protein	ISS	3768139	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00010	B cell activation	P00373	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	HUMAN|HGNC=173|UniProtKB=P27037	Activin receptor type-2A	TAS	11252892	PubMed	PTHR23255:SF64	ACTIVIN RECEPTOR TYPE-2A
P00010	B cell activation	P00385	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	IGI	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06827	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	RCA	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05731	GABA-B receptor II signaling	P05760	AC	MOUSE|MGI=MGI=99673|UniProtKB=P84309	Adenylate cyclase type 5	ISS	1409703	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00047	PDGF signaling pathway	P01143	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	IDA	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00709	Glycogen synthase D	MACMU|Ensembl=ENSMMUG00000016171|UniProtKB=F7FTD2	Uncharacterized protein	ISS	4212312	PubMed	PTHR10176:SF1	GLYCOGEN  STARCH  SYNTHASE, LIVER
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	MACMU|Ensembl=ENSMMUG00000010184|UniProtKB=F6SR09	Uncharacterized protein	ISS	7476890	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	9395335	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	IDA	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00010	B cell activation	P00385	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	10891487	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IGI	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04546	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	TAS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	MOUSE|MGI=MGI=94924|UniProtKB=P61168	D(2) dopamine receptor	RCA	2039532	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P05731	GABA-B receptor II signaling	P05754	Ggamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	RCA	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	ORYSJ|EnsemblGenome=OS03G0285800|UniProtKB=Q10N20	Mitogen-activated protein kinase 5	ISS			PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	CAEEL|WormBase=WBGene00008546|UniProtKB=Q19130	Glutamine-Fructose 6-phosphate AminoTransferase homolog	ISS			PTHR10937:SF0	GH12731P-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00053	T cell activation	P01307	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	ARATH|TAIR=AT3G08510|UniProtKB=Q39033	Phosphoinositide phospholipase C 2	TAS			PTHR10336:SF92	PHOSPHOINOSITIDE PHOSPHOLIPASE C 2-RELATED
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00019	Endothelin signaling pathway	P00591	PLCbeta	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00047	PDGF signaling pathway	P01174	Rho	MOUSE|MGI=MGI=1918552|UniProtKB=Q6ZQ82	Rho GTPase-activating protein 26	ISS	8649427	PubMed	PTHR12552:SF4	RHO GTPASE-ACTIVATING PROTEIN 26
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	P04609	PI3K	XENTR|Xenbase=XB-GENE-6085226|UniProtKB=F6ZM84	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00019	Endothelin signaling pathway	P00587	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000012922|UniProtKB=H2QJF2	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CAEBR|Gene=CBG02161|UniProtKB=A8WS32	Protein CBG02161	ISS	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00005	Angiogenesis	P00223	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01242	Casein kinase I	DROME|FlyBase=FBgn0030384|UniProtKB=Q9VYN5	AT26486p	IDA	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DROME|FlyBase=FBgn0000042|UniProtKB=P10987	Actin-5C	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	P01438	PP2A	DANRE|ZFIN=ZDB-GENE-040426-2487|UniProtKB=Q803G3	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00927	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00047	PDGF signaling pathway	P01160	IP3 receptor	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00975	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	2842690	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IPI	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	CAEBR|Gene=CBG02059|UniProtKB=A8WRW6	Protein CBR-UNC-2 (Fragment)	ISS	14507926	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P00010	B cell activation	P00373	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g195622|UniProtKB=A7T2Q5	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	TAKRU|Ensembl=ENSTRUG00000016101|UniProtKB=H2UW32	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IPI	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00020	FAS signaling pathway	P00615	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	PANTR|Ensembl=ENSPTRG00000011049|UniProtKB=H2QGF9	Glycogen synthase kinase 3 alpha	ISS	183955	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IC	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00012	Cadherin signaling pathway	P00462	Casein kinase II	CIOIN|Ensembl=ENSCING00000009515|UniProtKB=Q8T3S5	Casein kinase 2 alpha subunit	ISS	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00054	Toll receptor signaling pathway	P01369	MKK1	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P06213	DPP signaling pathway	P06285	DPP	DROME|FlyBase=FBgn0000490|UniProtKB=P07713	Protein decapentaplegic	IEA	http://flybase.org/reports/FBgn0000490.html	Website	PTHR11848:SF234	PROTEIN DECAPENTAPLEGIC
P06664	Gonadotropin-releasing hormone receptor pathway	P06807	gnai	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	RCA	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00034	Integrin signalling pathway	P00926	GRAF	RAT|RGD=1310923|UniProtKB=D3ZMS4	Protein Arhgap26	ISS	8649427	PubMed	PTHR12552:SF4	RHO GTPASE-ACTIVATING PROTEIN 26
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P02738	De novo purine biosynthesis	P02907	dADP kinase	BOVIN|Ensembl=ENSBTAG00000016552|UniProtKB=A5PK70	Nucleoside diphosphate kinase	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P00054	Toll receptor signaling pathway	P01355	AP1	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00010	B cell activation	P00379	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IPI	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00200	Dsh	MOUSE|MGI=MGI=106613|UniProtKB=Q60838	Segment polarity protein dishevelled homolog DVL-2	ISS	10409711	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P00034	Integrin signalling pathway	P00939	Fibronectin	MACMU|Ensembl=ENSMMUG00000012321|UniProtKB=F7EJH1	Uncharacterized protein	ISS	12970173	PubMed	PTHR19143:SF267	FIBRONECTIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	176892	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01058	Homer	MACMU|Ensembl=ENSMMUG00000017057|UniProtKB=F7HNK9	Uncharacterized protein	ISS	12653978	PubMed	PTHR10918:SF3	HOMER PROTEIN HOMOLOG 1
P00021	FGF signaling pathway	P00640	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01284	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00049	Parkinson disease	P01211	ERK	HUMAN|HGNC=24667|UniProtKB=Q8TD08	Mitogen-activated protein kinase 15	IDA	11875070	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	DROME|FlyBase=FBgn0010051|UniProtKB=P29993	Inositol 1,4,5-trisphosphate receptor	IC	9065779	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	DANRE|ZFIN=ZDB-GENE-020125-3|UniProtKB=E7F1V8	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PHYPA|Gene=PHYPADRAFT_225906|UniProtKB=A9TVP1	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00053	T cell activation	P01311	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	IEA	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	CHICK|Ensembl=ENSGALG00000009405|UniProtKB=F1NKF1	Uncharacterized protein	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P05913	Enkephalin release	P05973	GPCR (i)	PANTR|Ensembl=ENSPTRG00000000440|UniProtKB=H2PYH8	Uncharacterized protein	ISS	12093103	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00025	Hedgehog signaling pathway	P00682	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	14744463	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00010	B cell activation	P00383	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	HUMAN|HGNC=1497|UniProtKB=O14936	Peripheral plasma membrane protein CASK	ISS	11679592	PubMed	PTHR23122:SF40	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P02755	Methylmalonyl pathway	P03033	Propionyl-CoA carboxylase	MYCTU|EnsemblGenome=LH57_20710|UniProtKB=O53578	Methylmalonyl-CoA carboxyltransferase	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P00006	Apoptosis signaling pathway	P00303	c-Jun	XENTR|Xenbase=XB-GENE-482228|UniProtKB=F6RYL1	Uncharacterized protein	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04393	Ras Pathway	P04544	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	8479536	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00057	Wnt signaling pathway	P01465	Ggamma	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IDA	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	PANTR|Ensembl=ENSPTRG00000029076|UniProtKB=H2R686	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF63	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-2
P00018	EGF receptor signaling pathway	P00552	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P02788	Xanthine and guanine salvage pathway	P03245	Guanine phosphoribosyl transferase	BACTN|EnsemblGenome=BT_4386|UniProtKB=Q89ZJ1	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	HUMAN|HGNC=4573|UniProtKB=P42263	Glutamate receptor 3	ISS	12941441	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00047	PDGF signaling pathway	P01173	STAT	PANTR|Ensembl=ENSPTRG00000009199|UniProtKB=H2QD19	Signal transducer and activator of transcription	ISS	8584036	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	BOVIN|Ensembl=ENSBTAG00000039151|UniProtKB=F6R5F6	Uncharacterized protein	ISS	11701344	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00012	Cadherin signaling pathway	P00474	Wnt	DANRE|ZFIN=ZDB-GENE-990415-278|UniProtKB=P43446	Protein Wnt-10a	IDA	8717036	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00048	PI3 kinase pathway	P01192	p110	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00773	Duo	HUMAN|HGNC=4814|UniProtKB=O60229	Kalirin	ISS	9285789	PubMed	PTHR22826:SF49	KALIRIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00029	Huntington disease	P00786	ARF	SCHPO|PomBase=SPBC1539.08|UniProtKB=Q9Y7Z2	ADP-ribosylation factor 6	IPI	12932731	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00015	Circadian clock system	G01497	cry	MOUSE|MGI=MGI=1270841|UniProtKB=P97784	Cryptochrome-1	IDA	14507900	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00046	Oxidative stress response	P01129	JNK1/2	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS			PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04546	GSK3	PANTR|Ensembl=ENSPTRG00000011049|UniProtKB=H2QGF9	Glycogen synthase kinase 3 alpha	ISS	2164470	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00983	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00274	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	PANTR|Ensembl=ENSPTRG00000006872|UniProtKB=H2RCB4	Uncharacterized protein	ISS	15858232	PubMed	PTHR13715:SF16	RYANODINE RECEPTOR 3
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00373	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01336	Jnk	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02731	Biotin biosynthesis	P02859	Dethiobiotin synthase	YEAST|SGD=S000005340|UniProtKB=P53630	Dethiobiotin synthetase	ISS			PTHR43210:SF2	DETHIOBIOTIN SYNTHETASE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01181	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02738	De novo purine biosynthesis	P02891	GDP kinase	TRYB2|Gene=Tb11.01.7800|UniProtKB=Q381H3	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00048	PI3 kinase pathway	P01182	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000008719|UniProtKB=F1MZX0	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	IGI	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00049	Parkinson disease	P01211	ERK	BOVIN|Ensembl=ENSBTAG00000001014|UniProtKB=A5PKJ4	Mitogen-activated protein kinase 7	ISS	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01162	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00056	VEGF signaling pathway	P01414	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00021	FGF signaling pathway	P00645	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12912997	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05913	Enkephalin release	P05977	G-Protein (s)	CHICK|Ensembl=ENSGALG00000013785|UniProtKB=E1BS74	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00010	B cell activation	P00398	IP3R	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	IGI	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P06587	Nicotine pharmacodynamics pathway	P06604	SLC18A2	MACMU|Ensembl=ENSMMUG00000014817|UniProtKB=F6VXD8	Uncharacterized protein	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	MOUSE|MGI=MGI=2442252|UniProtKB=Q8VI56	Low-density lipoprotein receptor-related protein 4	IDA	11907044	PubMed	PTHR44017:SF4	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00568	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	IGI	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00047	PDGF signaling pathway	P01168	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	11292874	PubMed	PTHR10048:SF14	PI-3 KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	BOVIN|Ensembl=ENSBTAG00000006295|UniProtKB=P01223	Thyrotropin subunit beta	ISS	5101174	PubMed	PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	XENTR|Xenbase=XB-GENE-956713|UniProtKB=Q5XGD8	Guanine nucleotide binding protein, beta 3	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	HUMAN|HGNC=7577|UniProtKB=P12883	Myosin-7	IEP	89264452	PubMed	PTHR13140:SF344	MYOSIN-7
P00019	Endothelin signaling pathway	P00570	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00474	Wnt	RAT|RGD=1311441|UniProtKB=A0A0G2K3B7	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IDA	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	HUMAN|HGNC=145|UniProtKB=P63267	Actin, gamma-enteric smooth muscle	IDA	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P02749	Leucine biosynthesis	P03000	Branched chain amino acid aminotransferase	MOUSE|MGI=MGI=1276534|UniProtKB=O35855	Branched-chain-amino-acid aminotransferase, mitochondrial	ISS			PTHR11825:SF39	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, MITOCHONDRIAL
P00045	Notch signaling pathway	P01113	Pen-2	HUMAN|HGNC=9509|UniProtKB=P49810	Presenilin-2	IPI	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	IDA	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	TAS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	MACMU|Ensembl=ENSMMUG00000019731|UniProtKB=F7B606	Uncharacterized protein	ISS	11034345	PubMed	PTHR11647:SF58	DIHYDROPYRIMIDINASE-RELATED PROTEIN 5
P00005	Angiogenesis	P00221	JNK1	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02916	dTMP kinase	ECOLI|EcoGene=EG12302|UniProtKB=P0A720	Thymidylate kinase	ISS			PTHR10344:SF1	THYMIDYLATE KINASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	BOVIN|Ensembl=ENSBTAG00000005714|UniProtKB=Q3ZC07	Actin, alpha cardiac muscle 1	ISS	3487386	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IDA	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	10514528	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05731	GABA-B receptor II signaling	P05760	AC	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00961	STAT1	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	TAS	12461178	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P06664	Gonadotropin-releasing hormone receptor pathway	P06834	MAP3Ks	MOUSE|MGI=MGI=1346873|UniProtKB=Q61083	Mitogen-activated protein kinase kinase kinase 2	RCA	8621389	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00034	Integrin signalling pathway	P00941	Integrin alpha	MACMU|Ensembl=ENSMMUG00000002370|UniProtKB=F7BZD3	Uncharacterized protein	ISS	3487386	PubMed	PTHR23220:SF9	INTEGRIN ALPHA-6
P05731	GABA-B receptor II signaling	P05755	Gbeta	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00057	Wnt signaling pathway	P01452	NFAT	MACMU|Ensembl=ENSMMUG00000021843|UniProtKB=F6RNI3	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00048	PI3 kinase pathway	P01179	PKB	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	TAS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00049	Parkinson disease	P01211	ERK	BOVIN|Ensembl=ENSBTAG00000001014|UniProtKB=A5PKJ4	Mitogen-activated protein kinase 7	ISS	12912994	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00019	Endothelin signaling pathway	P00591	PLCbeta	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	CHICK|Ensembl=ENSGALG00000011905|UniProtKB=F1NHT7	Uncharacterized protein	TAS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00790	beta-Tubulin	XENTR|Xenbase=XB-GENE-482185|UniProtKB=Q6GLE7	Tubulin beta chain	ISS	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MONDO|Ensembl=ENSMODG00000004799|UniProtKB=F6VM87	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00012	Cadherin signaling pathway	P00465	TCF/LEF	PANTR|Ensembl=ENSPTRG00000016352|UniProtKB=H2QQ05	Uncharacterized protein	ISS	11266476	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00018	EGF receptor signaling pathway	P00557	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	IGI	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00020	FAS signaling pathway	P00615	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00034	Integrin signalling pathway	P00931	Integrin beta	HUMAN|Ensembl=ENSG00000259753|UniProtKB=H3BM21	Integrin beta (Fragment)	IDA	7949057	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00012	Cadherin signaling pathway	P00465	TCF/LEF	MOUSE|MGI=MGI=1202876|UniProtKB=Q9Z1J1	Transcription factor 7-like 1	ISS	12356903	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00048	PI3 kinase pathway	P01192	p110	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MOUSE|MGI=MGI=104589|UniProtKB=P63268	Actin, gamma-enteric smooth muscle	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DANRE|ZFIN=ZDB-GENE-030131-6503|UniProtKB=Q7ZUC5	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF297	PROTEIN KINASE C DELTA TYPE
P00022	General transcription by RNA polymerase I	P00654	TTF-I	MOUSE|MGI=MGI=105044|UniProtKB=Q62187	Transcription termination factor 1	IGI	9582279	PubMed	PTHR10641:SF939	TRANSCRIPTION TERMINATION FACTOR 1
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	MOUSE|MGI=MGI=99460|UniProtKB=Q61982	Neurogenic locus notch homolog protein 3	IDA	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00034	Integrin signalling pathway	P00912	Arp2/3	MACMU|Ensembl=ENSMMUG00000019342|UniProtKB=F6PVY4	Uncharacterized protein	ISS	12473693	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00006	Apoptosis signaling pathway	P00260	AKT	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	ISS	22084520	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000007523|UniProtKB=Q3SWZ3	Syntaxin-4	ISS			PTHR19957:SF97	SYNTAXIN-4
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IDA	10644715	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00023	General transcription regulation	P00658	TBP-associated factors	XENTR|Xenbase=XB-GENE-491356|UniProtKB=Q28J24	Transcription initiation factor TFIID subunit 8	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00019	Endothelin signaling pathway	P00576	Pre-pro ET1-4	HUMAN|HGNC=3177|UniProtKB=P20800	Endothelin-2	ISS	12516960	PubMed	PTHR13874:SF9	ENDOTHELIN-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00006	Apoptosis signaling pathway	P00268	GCK	CAEBR|Gene=CBG19019|UniProtKB=A8XUK9	Protein CBR-GCK-2	ISS			PTHR24361:SF413	HAPPYHOUR, ISOFORM A
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MACMU|Ensembl=ENSMMUG00000022111|UniProtKB=F7H7W3	Ribosomal protein S6 kinase	ISS	15226426	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	RAT|RGD=621516|UniProtKB=G3V6P8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2743|UniProtKB=P31421	Metabotropic glutamate receptor 2	IDA	12351712	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00021	FGF signaling pathway	P00633	Ras	TAKRU|Ensembl=ENSTRUG00000005329|UniProtKB=H2SK54	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00018	EGF receptor signaling pathway	P00552	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IDA	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01413	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	ISS	96009592	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	RAT|RGD=2246|UniProtKB=Q07652	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	14624853	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P06587	Nicotine pharmacodynamics pathway	P06604	SLC18A2	BOVIN|Gene=SLC18A2|UniProtKB=Q27963	Synaptic vesicular amine transporter	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	TAKRU|Ensembl=ENSTRUG00000006464|UniProtKB=H2STT5	Uncharacterized protein	ISS	1904317	PubMed	PTHR24070:SF382	RAS-RELATED PROTEIN RAP-1B
P00057	Wnt signaling pathway	P01439	C-terminal Binding Protein	RAT|RGD=68372|UniProtKB=Q9EQH5	C-terminal-binding protein 2	ISS	10375506	PubMed	PTHR10996:SF72	C-TERMINAL-BINDING PROTEIN 2
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P06664	Gonadotropin-releasing hormone receptor pathway	P06841	gnaq/11	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	RCA	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00562	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	CANLF|Ensembl=ENSCAFG00000013547|UniProtKB=E2QVP7	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF126	FRIZZLED-5
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00034	Integrin signalling pathway	P00913	Csk	HUMAN|HGNC=2444|UniProtKB=P41240	Tyrosine-protein kinase CSK	IDA	12665526	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	RCA	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MOUSE|MGI=MGI=1923959|UniProtKB=Q9CVB6	Actin-related protein 2/3 complex subunit 2	ISS	10940259	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CAEEL|WormBase=WBGene00006789|UniProtKB=P02566	Myosin-4	IC			PTHR13140:SF571	MYOSIN-4
P00057	Wnt signaling pathway	P01451	Galpha	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00054	Toll receptor signaling pathway	P01358	ERK1	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00642	MEK1-2	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P06959	CCKR signaling map	P07165	STAT3	HUMAN|HGNC=11364|UniProtKB=P40763	Signal transducer and activator of transcription 3	RCA	15640156	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	RAT|RGD=2848|UniProtKB=P08909	5-hydroxytryptamine receptor 2C	ISS	8143856	PubMed	PTHR24247:SF32	5-HYDROXYTRYPTAMINE RECEPTOR 2C
P00005	Angiogenesis	P00219	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IC	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	PANTR|Ensembl=ENSPTRG00000002775|UniProtKB=H2RB55	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00010	B cell activation	P00384	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IDA	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TRIVA|Gene=TVAG_054030|UniProtKB=A2G1K5	Actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00030	Hypoxia response via HIF activation	P00823	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00641	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	ORNAN|Ensembl=ENSOANG00000000460|UniProtKB=F7F4W9	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IDA	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CHICK|Ensembl=ENSGALG00000002098|UniProtKB=F1P0L4	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00057	Wnt signaling pathway	P01465	Ggamma	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00924	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	IPI	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-478663|UniProtKB=F7EG64	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00805	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	G01529	Proline oxidase	PANTR|Ensembl=ENSPTRG00000038736|UniProtKB=H2QG46	Uncharacterized protein	ISS			PTHR13914:SF5	PROLINE DEHYDROGENASE 2-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CAEEL|WormBase=WBGene00013534|UniProtKB=H2KML8	AcetylCholine Receptor	IC			PTHR18945:SF462	ACETYLCHOLINE RECEPTOR
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P02723	Adenine and hypoxanthine salvage pathway	P02804	Hypoxanthine phosphoribosyl transferase	TRYB2|Gene=Tb10.70.6540|UniProtKB=Q38C93	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	RAT|RGD=69079|UniProtKB=M0R9D3	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	YEAST|SGD=S000000201|UniProtKB=P24583	Protein kinase C-like 1	TAS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	MOUSE|MGI=MGI=99460|UniProtKB=Q61982	Neurogenic locus notch homolog protein 3	IDA	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05917	Opioid proopiomelanocortin pathway	P06009	K+ channel	MOUSE|MGI=MGI=3521816|UniProtKB=Q3LS21	Potassium channel subfamily K member 9	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00030	Hypoxia response via HIF activation	P00819	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P06587	Nicotine pharmacodynamics pathway	P06590	GNG	XENTR|Xenbase=XB-GENE-961282|UniProtKB=Q6DF43	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00030	Hypoxia response via HIF activation	P00814	P300	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00048	PI3 kinase pathway	P01190	PDK1 ACT	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00049	Parkinson disease	P01208	Hsp70	PLAF7|EnsemblGenome=PF11_0351|UniProtKB=Q8II24	Heat shock protein 70	IDA	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P00029	Huntington disease	P00780	Microtubule	HUMAN|HGNC=20773|UniProtKB=Q3ZCM7	Tubulin beta-8 chain	IDA	9454836	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00057	Wnt signaling pathway	P01443	Phospholipase C	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04392	P53 pathway feedback loops 1	G04682	MDM-2	BOVIN|Gene=MDM4|UniProtKB=Q2HJ21	Protein Mdm4	ISS			PTHR13844:SF20	PROTEIN MDM4
P00036	Interleukin signaling pathway	P00983	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	3449797	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00047	PDGF signaling pathway	P01154	Ras	RAT|RGD=68369|UniProtKB=O35509	Ras-related protein Rab-11B	ISS			PTHR24073:SF335	RAS-RELATED PROTEIN RAB-11B
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	SCHPO|PomBase=SPAC17G8.14c|UniProtKB=P36582	Protein kinase C-like 1	IC	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P05915	Opioid proenkephalin pathway	P05988	peptide E	XENTR|Xenbase=XB-GENE-942760|UniProtKB=F6Y5F6	Uncharacterized protein	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00049	Parkinson disease	P01238	14-3-3	ARATH|TAIR=AT2G42590|UniProtKB=Q96299	14-3-3-like protein GF14 mu	IDA	10407019	PubMed	PTHR18860:SF31	14-3-3-LIKE PROTEIN GF14 MU
P04374	5HT2 type receptor mediated signaling pathway	P04417	5HT transporter	HUMAN|HGNC=11050|UniProtKB=P31645	Sodium-dependent serotonin transporter	ISS	7681602	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P06959	CCKR signaling map	P07199	GSK3beta	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	RCA	20637111	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	YEAST|SGD=S000005854|UniProtKB=P33328	Synaptobrevin homolog 2	IC			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00923	Arf1	SCHPO|PomBase=SPBC4F6.18c|UniProtKB=P36579	ADP-ribosylation factor 1	IPI	11752622	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P04398	p53 pathway feedback loops 2	P04657	P110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00177	Nectin 1alpha C-terminal fragment	HUMAN|HGNC=9706|UniProtKB=Q15223	Nectin-1	ISS	12376527	PubMed	PTHR23277:SF69	NECTIN-1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	MOUSE|MGI=MGI=88461|UniProtKB=E9PWQ3	Protein Col6a3	IC	10778855	PubMed	PTHR44105:SF2	COLLAGEN ALPHA-3 VI  CHAIN
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DICDI|dictyBase=DDB_G0275023|UniProtKB=Q553U6	Putative actin-22	IC	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	HUMAN|HGNC=4383|UniProtKB=P30679	Guanine nucleotide-binding protein subunit alpha-15	IC	11534853	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P00036	Interleukin signaling pathway	P00977	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00006	Apoptosis signaling pathway	P00322	Cytochrome C	BOVIN|Ensembl=ENSBTAG00000025310|UniProtKB=E1BA13	Uncharacterized protein	ISS	5968568	PubMed	PTHR11961:SF15	CYTOCHROME C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TAKRU|Ensembl=ENSTRUG00000007989|UniProtKB=P68140	Actin, alpha skeletal muscle A	IC	10974003	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	MACMU|Ensembl=ENSMMUG00000018272|UniProtKB=F7HEB8	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00019	Endothelin signaling pathway	P00589	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	PANTR|Ensembl=ENSPTRG00000002979|UniProtKB=H2Q2M8	Uncharacterized protein	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00056	VEGF signaling pathway	P01408	Akt/PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05913	Enkephalin release	P05974	G-Protein (i)	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04372	5-Hydroxytryptamine degredation	P04401	Monoamine Oxidase	RAT|RGD=61898|UniProtKB=P21396	Amine oxidase [flavin-containing] A	ISS	8602220	PubMed	PTHR43563:SF3	AMINE OXIDASE  FLAVIN-CONTAINING  A
P04393	Ras Pathway	P04546	GSK3	STRPU|EnsemblGenome=SPU_009263|UniProtKB=W4Y0P1	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CANLF|Ensembl=ENSCAFG00000008756|UniProtKB=F2Z4N8	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00012	Cadherin signaling pathway	P00463	betacatenin	HUMAN|HGNC=2514|UniProtKB=P35222	Catenin beta-1	IDA	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00020	FAS signaling pathway	P00616	Nuclear Lamin	PANTR|Ensembl=ENSPTRG00000001447|UniProtKB=H2Q091	Uncharacterized protein	ISS	11165516	PubMed	PTHR23239:SF158	PRELAMIN-A/C
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IDA	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DANRE|ZFIN=ZDB-GENE-030131-1229|UniProtKB=Q6DHS1	Actin, alpha 2, smooth muscle, aorta	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	TAS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01311	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IDA	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00056	VEGF signaling pathway	P01407	Erk	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00632	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	CHICK|Ensembl=ENSGALG00000014539|UniProtKB=F1N861	Uncharacterized protein	ISS	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00021	FGF signaling pathway	P00644	p38	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00029	Huntington disease	P00790	beta-Tubulin	PRIPA|Gene=PPA02893|UniProtKB=H3DZP2	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF120	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00562	p38	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=262|UniProtKB=P30542	Adenosine receptor A1	ISS	12515326	PubMed	PTHR24246:SF1	ADENOSINE RECEPTOR A1
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	PANTR|Ensembl=ENSPTRG00000000827|UniProtKB=H2PZ67	Adenylate kinase 4, mitochondrial	ISS			PTHR23359:SF58	ADENYLATE KINASE 4, MITOCHONDRIAL
P04393	Ras Pathway	P04556	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IDA	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02779	Thiamin biosynthesis	P03175	1-Deoxyxylulose-5-phosphate synthase	FUSNN|EnsemblGenome=FN1208|UniProtKB=Q8R639	1-deoxy-D-xylulose-5-phosphate synthase	ISS			PTHR43322:SF6	1-DEOXY-D-XYLULOSE-5-PHOSPHATE SYNTHASE
P00005	Angiogenesis	P00238	Ras	DANRE|ZFIN=ZDB-GENE-990415-166|UniProtKB=P79737	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	CAEEL|WormBase=WBGene00001746|UniProtKB=Q9U2Q9	Glycogen synthase kinase-3	ISS	12615961	PubMed	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P04397	p53 pathway by glucose deprivation	P04640	p53	PANTR|Ensembl=ENSPTRG00000008703|UniProtKB=H2QC53	Cellular tumor antigen p53	ISS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	TAS	12846562	PubMed	PTHR10202:SF13	PRESENILIN-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	BACSU|EnsemblGenome=BSU31400|UniProtKB=Q795M6	Putative aminotransferase YugH	ISS			PTHR43795:SF21	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00018	EGF receptor signaling pathway	P00548	RKIP	DROME|FlyBase=FBgn0032453|UniProtKB=Q9VK60	CG6180	ISS			PTHR11362:SF28	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	MACMU|Ensembl=ENSMMUG00000004046|UniProtKB=F6ZR77	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	HUMAN|HGNC=144|UniProtKB=P63261	Actin, cytoplasmic 2	IDA	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00049	Parkinson disease	P01213	Cyclin E	HUMAN|HGNC=1589|UniProtKB=P24864	G1/S-specific cyclin-E1	IDA	12729791	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	DROME|FlyBase=FBgn0025595|UniProtKB=Q7KTL9	Adipokinetic hormone receptor, isoform C	IDA	12629106	PubMed	PTHR24241:SF59	ADIPOKINETIC HORMONE RECEPTOR, ISOFORM C
P04393	Ras Pathway	P04557	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IDA	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=69424|UniProtKB=Q99P84	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	12860966	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00006	Apoptosis signaling pathway	P00310	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00007	Axon guidance mediated by semaphorins	P00334	PlexinA1	CANLF|Ensembl=ENSCAFG00000003989|UniProtKB=F1P6G0	Uncharacterized protein	ISS	10520995	PubMed	PTHR22625:SF35	PLEXIN-A1
P00010	B cell activation	P00379	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF31	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04495	TSC1	PANTR|Ensembl=ENSPTRG00000021504|UniProtKB=H2QY35	Tuberous sclerosis 1	ISS	12167664	PubMed	PTHR15154:SF2	HAMARTIN
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000005865|UniProtKB=G5E577	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	CAEBR|Gene=CBG23008|UniProtKB=A8Y3G4	Protein CBR-ALH-1	ISS			PTHR11699:SF265	ALDEHYDE DEHYDROGENASE
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00225	MEK	BOVIN|Ensembl=ENSBTAG00000005865|UniProtKB=G5E577	Uncharacterized protein	ISS			PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	MACMU|Ensembl=ENSMMUG00000019817|UniProtKB=F7FY63	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00545	JNK1-3	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00034	Integrin signalling pathway	P00921	PINCH	TAKRU|Ensembl=ENSTRUG00000017198|UniProtKB=H2V4D3	Uncharacterized protein	ISS			PTHR24210:SF0	AT21926P
P00021	FGF signaling pathway	P00641	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00012	Cadherin signaling pathway	P00464	Fyn	CANLF|Ensembl=ENSCAFG00000003995|UniProtKB=E2RC09	Tyrosine-protein kinase	ISS	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CAEEL|WormBase=WBGene00000063|UniProtKB=P0DM41	Actin-1	ISS	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00012	Cadherin signaling pathway	P00475	Frizzled	MACMU|Ensembl=ENSMMUG00000004048|UniProtKB=F6ZR92	Frizzled-4	ISS	8717036	PubMed	PTHR11309:SF23	FRIZZLED-4
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MACMU|Ensembl=ENSMMUG00000013187|UniProtKB=F6XQ37	Tubulin beta-1 chain	ISS	12932731	PubMed	PTHR11588:SF112	TUBULIN BETA-1 CHAIN
P00021	FGF signaling pathway	P00627	ERK1-2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	HUMAN|HGNC=7883|UniProtKB=Q9UM47	Neurogenic locus notch homolog protein 3	IDA	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346347|UniProtKB=Q9WVS8	Mitogen-activated protein kinase 7	IDA	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00010	B cell activation	P00397	IKK	RAT|RGD=1306661|UniProtKB=G3V926	Conserved helix-loop-helix ubiquitous kinase (Predicted)	ISS	12813046	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	DROME|FlyBase=FBgn0040206|UniProtKB=Q9V393	Kurtz arrestin	IDA	9388255	PubMed	PTHR11792:SF17	KURTZ ARRESTIN
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IDA	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	CANLF|Ensembl=ENSCAFG00000008883|UniProtKB=F1Q3H3	Metalloendopeptidase	ISS	9759503	PubMed	PTHR43978:SF4	TOLLOID-LIKE PROTEIN 1
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000010069|UniProtKB=H2QEM1	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF84	CADHERIN-20
P00034	Integrin signalling pathway	P00931	Integrin beta	HUMAN|Ensembl=ENSG00000259753|UniProtKB=H3BM21	Integrin beta (Fragment)	IDA	124968	gi	PTHR10082:SF25	INTEGRIN BETA-3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05941	GRK3	BOVIN|Gene=ADRBK2|UniProtKB=P26818	Beta-adrenergic receptor kinase 2	RCA	10852916	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P00006	Apoptosis signaling pathway	P00269	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	XENTR|Xenbase=XB-GENE-961282|UniProtKB=Q6DF43	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CAEBR|Gene=CBG01555|UniProtKB=A8WRD7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Ensembl=ENSBTAG00000013047|UniProtKB=E1BLE8	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00006	Apoptosis signaling pathway	P00274	JNK	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00046	Oxidative stress response	P01135	p38	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	8920915	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	BOVIN|Ensembl=ENSBTAG00000014674|UniProtKB=P41985	Muscarinic acetylcholine receptor M2	ISS	91373358	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00029	Huntington disease	P00778	NMDA receptor	HUMAN|HGNC=4584|UniProtKB=Q05586	Glutamate receptor ionotropic, NMDA 1	IDA	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00047	PDGF signaling pathway	P01152	RasGAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	ISS	88318957	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00047	PDGF signaling pathway	P01152	RasGAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00007	Axon guidance mediated by semaphorins	P00341	Rho	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00003	Alzheimer disease-amyloid secretase pathway	P00081	Pro-BACE-1	MONDO|Ensembl=ENSMODG00000013692|UniProtKB=F6QP52	Uncharacterized protein	ISS	10956649	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Gene=CHRM1|UniProtKB=P56489	Muscarinic acetylcholine receptor M1	IDA			PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00060	Ubiquitin proteasome pathway	P01492	E1	ARATH|TAIR=AT2G30110|UniProtKB=P93028	Ubiquitin-activating enzyme E1 1	ISS			PTHR10953:SF189	UBIQUITIN-ACTIVATING ENZYME E1 1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	ORNAN|Ensembl=ENSOANG00000010680|UniProtKB=F6U4A0	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02918	dUTP pyrophosphatase	MYCTU|EnsemblGenome=Rv2697c|UniProtKB=P9WNS5	Deoxyuridine 5'-triphosphate nucleotidohydrolase	ISS			PTHR11241:SF0	BCDNA.LD08534
P02738	De novo purine biosynthesis	P02900	AICAR transformylase	PSEAE|EnsemblGenome=PA4854|UniProtKB=Q9HUV9	Bifunctional purine biosynthesis protein PurH	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TRIVA|Gene=TVAG_090470|UniProtKB=A2FA04	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00046	Oxidative stress response	P01135	p38	DANRE|ZFIN=ZDB-GENE-990415-257|UniProtKB=O42376	Mitogen-activated protein kinase 12	TAS	10514528	PubMed	PTHR24055:SF339	MITOGEN-ACTIVATED PROTEIN KINASE 12
P02740	De novo pyrimidine ribonucleotides biosythesis	P02922	Orotate phosphoribosyltransferase	ANOGA|EnsemblGenome=AGAP004175|UniProtKB=Q7QB57	AGAP004175-PA	ISS			PTHR19278:SF9	URIDINE 5'-MONOPHOSPHATE SYNTHASE
P00047	PDGF signaling pathway	P01148	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	TAS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00036	Interleukin signaling pathway	P00981	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00019	Endothelin signaling pathway	P00566	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00023	General transcription regulation	P00658	TBP-associated factors	ARATH|TAIR=AT4G34340|UniProtKB=Q9SYZ9	Transcription initiation factor TFIID subunit 8	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00052	TGF-beta signaling pathway	P01292	RSmads	MONDO|Ensembl=ENSMODG00000000500|UniProtKB=F6TU68	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P00019	Endothelin signaling pathway	P00590	IP3 R	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	IGI	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P05915	Opioid proenkephalin pathway	P05994	G-protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00007	Axon guidance mediated by semaphorins	P00340	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00018	EGF receptor signaling pathway	P00552	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P06959	CCKR signaling map	P07140	PKCtheta	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	RCA	22786615	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00053	T cell activation	P01320	PLC-gamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00036	Interleukin signaling pathway	P00990	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00547	PP2A	RAT|RGD=3381|UniProtKB=P62716	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00036	Interleukin signaling pathway	P00996	STAT	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	14984365	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00019	Endothelin signaling pathway	P00570	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	HUMAN|HGNC=7882|UniProtKB=Q04721	Neurogenic locus notch homolog protein 2	IDA	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00006	Apoptosis signaling pathway	P00318	PKCs	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00006	Apoptosis signaling pathway	P00260	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00539	14-3-3	CANLF|Ensembl=ENSCAFG00000000580|UniProtKB=F1PBL1	Uncharacterized protein	ISS	92362864	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00047	PDGF signaling pathway	P01172	c-Myc	BOVIN|Ensembl=ENSBTAG00000008409|UniProtKB=Q2HJ27	Myc proto-oncogene protein	ISS	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00059	p53 pathway	P04623	CBP	ARATH|TAIR=AT1G79000|UniProtKB=Q9C5X9	Histone acetyltransferase HAC1	ISS	10823891	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00010	B cell activation	P00384	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	PSEAE|EnsemblGenome=PA3759|UniProtKB=Q9HXN6	Probable aminotransferase	ISS			PTHR10937:SF8	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00543	ERK1-2	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IGI	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	STRPU|EnsemblGenome=SPU_026078|UniProtKB=W4ZD41	Uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF277	SUBFAMILY NOT NAMED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00547	PP2A	MOUSE|MGI=MGI=2388481|UniProtKB=Q91V89	Protein Ppp2r5d	ISS	96161994	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00070	VAT2	MACMU|Ensembl=ENSMMUG00000014817|UniProtKB=F6VXD8	Uncharacterized protein	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00049	Parkinson disease	P01238	14-3-3	BOVIN|Ensembl=ENSBTAG00000005664|UniProtKB=P62261	14-3-3 protein epsilon	ISS	98119747	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	RAT|RGD=3380|UniProtKB=P63331	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	PANTR|Ensembl=ENSPTRG00000002371|UniProtKB=H2Q1R1	Uncharacterized protein	ISS	22028976	PubMed	PTHR13140:SF387	MYOSIN-IIIA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MACMU|Ensembl=ENSMMUG00000019351|UniProtKB=Q2YEG0	C-X-C chemokine receptor type 1	ISS	4504683	gi	PTHR10489:SF916	C-X-C CHEMOKINE RECEPTOR TYPE 1
P02757	O-antigen biosynthesis	P03052	N-acetylglucosamine-1-phosphate uridyltransferase	STRCO|EnsemblGenome=CAD55493|UniProtKB=Q8CJX6	Bifunctional protein GlmU	ISS			PTHR43584:SF3	BIFUNCTIONAL PROTEIN GLMU
P04397	p53 pathway by glucose deprivation	P04636	S6K	MONDO|Ensembl=ENSMODG00000014313|UniProtKB=F7BTW0	Ribosomal protein S6 kinase	ISS	15116068	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00034	Integrin signalling pathway	P00944	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g210933|UniProtKB=A7SEA7	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P06959	CCKR signaling map	P07090	MAPK8-10	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	RCA	9003778	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00012	Cadherin signaling pathway	P00462	Casein kinase II	MOUSE|MGI=MGI=88548|UniProtKB=P67871	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00036	Interleukin signaling pathway	P00973	PKB	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00717	Phosphorylase b	HUMAN|HGNC=9725|UniProtKB=P06737	Glycogen phosphorylase, liver form	IDA	4318782	PubMed	PTHR11468:SF12	GLYCOGEN PHOSPHORYLASE, LIVER FORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	IDA	10207617	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00059	p53 pathway	P01480	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	ISS	94131270	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00013	Cell cycle	P00483	Cyclin E	MOUSE|MGI=MGI=88316|UniProtKB=Q61457	G1/S-specific cyclin-E1	ISS	15705141	gi	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	15572354	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00012	Cadherin signaling pathway	P00469	Fer	CANLF|Gene=FER|UniProtKB=Q9TTY2	Tyrosine-protein kinase Fer	ISS	9742093	PubMed	PTHR24418:SF227	TYROSINE-PROTEIN KINASE FER
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00048	PI3 kinase pathway	P01177	P110ACT	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00803	Sp1	DROME|FlyBase=FBgn0020378|UniProtKB=M9PJG1	Sp1, isoform F	IDA	11988536	PubMed	PTHR23235:SF15	SP1, ISOFORM F-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	TAKRU|Ensembl=ENSTRUG00000016241|UniProtKB=H2UX35	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF305	PROTEIN KINASE C
P00025	Hedgehog signaling pathway	P00690	Cubitus interruptus	RAT|RGD=620272|UniProtKB=F1M9H1	Protein Gli3	ISS	10976059	PubMed	PTHR19818:SF5	TRANSCRIPTIONAL ACTIVATOR GLI3
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00385	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01407	Erk	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	IC	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00564	Rac	DROME|FlyBase=FBgn0010333|UniProtKB=P40792	Ras-related protein Rac1	IGI	8649368	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00034	Integrin signalling pathway	P00942	Fyn	DANRE|ZFIN=ZDB-GENE-050706-89|UniProtKB=F1RDG9	Tyrosine-protein kinase fynb	ISS	11162638	PubMed	PTHR24418:SF242	TYROSINE-PROTEIN KINASE FYNB
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	11956331	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P04375	5HT3 type receptor mediated signaling pathway	P04425	K+ channel	MACMU|Ensembl=ENSMMUG00000005826|UniProtKB=F6VE51	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	ISS	15860573	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00017	DNA replication	P00527	Histones	DANRE|Ensembl=ENSDARG00000020504|UniProtKB=Q6PI20	Histone H3.3	ISS	20448842	PubMed	PTHR11426:SF179	HISTONE H3.3
P06664	Gonadotropin-releasing hormone receptor pathway	G06667	PACAP	MOUSE|MGI=MGI=105094|UniProtKB=O70176	Pituitary adenylate cyclase-activating polypeptide	RCA			PTHR11213:SF1	PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00373	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	PANTR|Ensembl=ENSPTRG00000003983|UniProtKB=H2Q4A0	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00006	Apoptosis signaling pathway	P00260	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00557	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IGI	96009592	PubMed	PTHR10048:SF14	PI-3 KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	ANOGA|EnsemblGenome=AGAP005911|UniProtKB=Q7Q6D4	AGAP005911-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	BOVIN|Ensembl=ENSBTAG00000000469|UniProtKB=P67774	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00640	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00800	PolyQ Htt	MOUSE|MGI=MGI=96067|UniProtKB=P42859	Huntingtin	TAS	8268927	PubMed	PTHR10170:SF10	HUNTINGTIN
P05731	GABA-B receptor II signaling	P05758	K channel	HUMAN|HGNC=6264|UniProtKB=P48549	G protein-activated inward rectifier potassium channel 1	RCA	2433589	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	RAT|RGD=620676|UniProtKB=F1M7N7	Ribosomal protein S6 kinase	ISS	1922062	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P05913	Enkephalin release	P05972	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00020	FAS signaling pathway	P00608	Pro-Caspase3	TAKRU|Ensembl=ENSTRUG00000015915|UniProtKB=H2UUR6	Uncharacterized protein (Fragment)	IGI	11675509	PubMed	PTHR10454:SF198	CASPASE-3
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IGI	88234494	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00629	PP2A	TAKRU|Ensembl=ENSTRUG00000008018|UniProtKB=H2T5N4	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01443	Phospholipase C	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	SCHMA|EnsemblGenome=Smp_183710|UniProtKB=G4VLW1	Putative actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	TAS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	10747026	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	CAEEL|WormBase=WBGene00017610|UniProtKB=Q19599	Uncharacterized protein	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	MOUSE|MGI=MGI=1096331|UniProtKB=O35544	Excitatory amino acid transporter 4	ISS	94365697	PubMed	PTHR11958:SF67	EXCITATORY AMINO ACID TRANSPORTER 4
P00057	Wnt signaling pathway	P01458	Protein Kinase C	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	IDA	10395542	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00047	PDGF signaling pathway	P01143	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	20216076	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05731	GABA-B receptor II signaling	P05752	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02926	Aspartate carbamoyltransferase	ORYSJ|EnsemblGenome=OS08G0248800|UniProtKB=Q9LD61	Aspartate carbamoyltransferase, chloroplastic	ISS			PTHR11405:SF16	ASPARTATE CARBAMOYLTRANSFERASE, CHLOROPLASTIC
P00049	Parkinson disease	P01242	Casein kinase I	DROME|FlyBase=FBgn0031441|UniProtKB=Q9VQE3	CG9962	IDA	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00048	PI3 kinase pathway	P01177	P110ACT	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000022548|UniProtKB=F6Y9J9	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	CANLF|Ensembl=ENSCAFG00000008977|UniProtKB=J9P7Q4	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF4	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00029	Huntington disease	P00785	Cytochrome c	LEIMA|EnsemblGenome=LmjF.07.0060|UniProtKB=Q4QIT8	Putative cytochrome c1, heme protein,mitochondrial	ISS	15163634	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	PANTR|Ensembl=ENSPTRG00000004701|UniProtKB=H2Q5G9	Low density lipoprotein receptor-related protein 6	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	20027584	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00019	Endothelin signaling pathway	P00591	PLCbeta	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IGI	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00047	PDGF signaling pathway	P01171	PLCgamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00059	p53 pathway	G04694	p110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00111	C99	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	ANOGA|EnsemblGenome=AGAP010172|UniProtKB=Q7PD38	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04546	GSK3	MOUSE|MGI=MGI=2152453|UniProtKB=Q2NL51	Glycogen synthase kinase-3 alpha	ISS	2164470	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00046	Oxidative stress response	P01134	cPLA2	DANRE|ZFIN=ZDB-GENE-990415-45|UniProtKB=P50392	Cytosolic phospholipase A2	TAS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00046	Oxidative stress response	P01135	p38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	TAS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00019	Endothelin signaling pathway	P00588	ET1-4	BOVIN|Ensembl=ENSBTAG00000008096|UniProtKB=P17322	Endothelin-1	ISS			PTHR13874:SF10	ENDOTHELIN-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	PANTR|Ensembl=ENSPTRG00000020105|UniProtKB=Q5IS52	Neuronal acetylcholine receptor subunit alpha-2	ISS	85270494	PubMed	PTHR18945:SF757	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	HUMAN|HGNC=1953|UniProtKB=P08173	Muscarinic acetylcholine receptor M4	ISS	12181435	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P02743	Formyltetrahydroformate biosynthesis	P02953	Cobalamin dependent homocysteine transmethylase	STRCO|Gene=CAD55372|UniProtKB=Q8CJP1	Putative transferase	ISS			PTHR21091:SF123	FI01821P
P00053	T cell activation	P01312	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00035	Interferon-gamma signaling pathway	P00956	SOCS	MACMU|Ensembl=ENSMMUG00000012610|UniProtKB=F7F5C0	Uncharacterized protein	ISS	12645661	PubMed	PTHR44562:SF1	SUPPRESSOR OF CYTOKINE SIGNALING 6
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014262|UniProtKB=F7BYS8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	HUMAN|HGNC=4403|UniProtKB=P61952	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	RCA	2122451	PubMed	PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	XENTR|Xenbase=XB-GENE-484032|UniProtKB=F6QWD3	Tyrosine-protein kinase receptor	ISS	249616	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P04395	Vasopressin synthesis	P04594	Neurophysin	TAKRU|Ensembl=ENSTRUG00000015631|UniProtKB=H2USP0	Uncharacterized protein	ISS			PTHR11681:SF14	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00049	Parkinson disease	P01211	ERK	RAT|RGD=628675|UniProtKB=Q9Z2A6	Mitogen-activated protein kinase 15	IDA	10851062	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00048	PI3 kinase pathway	P01192	p110	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00927	Rac	ENTHI|EnsemblGenome=EHI_129750|UniProtKB=C4M5Q7	Rho family GTPase	IGI	8649368	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P02771	Pyrimidine Metabolism	P03129	Aminotransferase	CANLF|Ensembl=ENSCAFG00000019030|UniProtKB=E2R776	Uncharacterized protein	ISS	10989446	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00018	EGF receptor signaling pathway	P00558	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00021	FGF signaling pathway	P00645	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	10540223	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00023	General transcription regulation	P00664	TFIIH complex	MOUSE|MGI=MGI=1338799|UniProtKB=O70422	General transcription factor IIH subunit 4	ISS			PTHR13152:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4
P00055	Transcription regulation by bZIP transcription factor	P01396	TFIIFbeta	HUMAN|HGNC=4653|UniProtKB=P13984	General transcription factor IIF subunit 2	ISS			PTHR10445:SF0	GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2
P00053	T cell activation	P01306	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00006	Apoptosis signaling pathway	P00319	TRADD	MOUSE|MGI=MGI=109200|UniProtKB=Q3U0V2	Tumor necrosis factor receptor type 1-associated DEATH domain protein	ISS			PTHR14913:SF0	TUMOR NECROSIS FACTOR RECEPTOR TYPE 1-ASSOCIATED DEATH DOMAIN PROTEIN
P02759	Pyridoxal-5-phosphate biosynthesis	P03058	Phosphohydroxythreonine aminotransferase	LEPIN|EnsemblGenome=LA_0366|UniProtKB=Q8F930	Phosphoserine aminotransferase	ISS			PTHR43247:SF2	PHOSPHOSERINE AMINOTRANSFERASE
P00005	Angiogenesis	P00254	GTPase	HUMAN|HGNC=667|UniProtKB=P61586	Transforming protein RhoA	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MOUSE|MGI=MGI=2152453|UniProtKB=Q2NL51	Glycogen synthase kinase-3 alpha	ISS	183955	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00048	PI3 kinase pathway	P01192	p110	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00539	14-3-3	HUMAN|HGNC=12851|UniProtKB=P62258	14-3-3 protein epsilon	ISS	9450960	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00006	Apoptosis signaling pathway	P00260	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IDA	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=1336171|UniProtKB=Q9DAS9	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02759	Pyridoxal-5-phosphate biosynthesis	P03061	Pyridoxine-5-phosphate oxidase	ANOGA|EnsemblGenome=AGAP002227|UniProtKB=Q7QK95	AGAP002227-PA	ISS			PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	MOUSE|MGI=MGI=2150309|UniProtKB=Q4VA61	Down syndrome cell adhesion molecule-like protein 1 homolog	ISS			PTHR44107:SF3	DOWN SYNDROME CELL ADHESION MOLECULE-LIKE PROTEIN 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000025240|UniProtKB=F7A7I3	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00057	Wnt signaling pathway	P01428	Frizzled	MOUSE|MGI=MGI=1313278|UniProtKB=Q9R216	Frizzled-9	IDA	11212302	PubMed	PTHR11309:SF79	FRIZZLED-9
P05913	Enkephalin release	G06045	preproenkephalin	MACMU|Ensembl=ENSMMUG00000006775|UniProtKB=F7H3N8	Uncharacterized protein	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00025	Hedgehog signaling pathway	P00682	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	176892	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P04393	Ras Pathway	P04570	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	IDA	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	IC	91298951	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P02738	De novo purine biosynthesis	P02908	Phosphoribosylamine glycine ligase	FUSNN|EnsemblGenome=FN0981|UniProtKB=Q8REV7	Phosphoribosylamine--glycine ligase	ISS			PTHR43472:SF1	PHOSPHORIBOSYLAMINE--GLYCINE LIGASE
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	DROME|FlyBase=FBgn0011300|UniProtKB=A1Z7L8	Receptor protein serine/threonine kinase	TAS	10683140	PubMed	PTHR23255:SF71	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01226	CDCrel-1	RAT|RGD=620056|UniProtKB=Q91Y81	Septin-2	IDA			PTHR18884:SF67	SEPTIN-2
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01211	ERK	BOVIN|Ensembl=ENSBTAG00000001014|UniProtKB=A5PKJ4	Mitogen-activated protein kinase 7	ISS	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01177	P110ACT	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00045	Notch signaling pathway	P01103	Next	CANLF|Ensembl=ENSCAFG00000019633|UniProtKB=F1PDC7	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00006	Apoptosis signaling pathway	P00317	Fos	MONDO|Ensembl=ENSMODG00000005927|UniProtKB=F6WX28	Uncharacterized protein	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00006	Apoptosis signaling pathway	P00310	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00052	TGF-beta signaling pathway	P01286	TGFbeta	CANLF|Ensembl=ENSCAFG00000002345|UniProtKB=E2RNJ0	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF139	BONE MORPHOGENETIC PROTEIN 5
P00054	Toll receptor signaling pathway	P01375	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00139	E-cadherin transmembrane fragment	RAT|RGD=621089|UniProtKB=F1LMI3	Cadherin 3, type 1, P-cadherin (Placental)	ISS	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P00005	Angiogenesis	P00187	beta catenin	MONDO|Ensembl=ENSMODG00000011192|UniProtKB=F6SRK5	Uncharacterized protein	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MACMU|Ensembl=ENSMMUG00000010440|UniProtKB=F7CRV6	Uncharacterized protein	ISS	8163524	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CAEEL|WormBase=WBGene00001187|UniProtKB=Q8MQA1	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00021	FGF signaling pathway	P00627	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00029	Huntington disease	P00805	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00019	Endothelin signaling pathway	P00576	Pre-pro ET1-4	MACMU|Ensembl=ENSMMUG00000007263|UniProtKB=F7FGG2	Preproendothelin-1	ISS	15117818	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P00059	p53 pathway	P04623	CBP	CAEEL|WormBase=WBGene00000366|UniProtKB=P34545	Protein cbp-1	ISS	10664585	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00053	T cell activation	P01311	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00899	IRS 1-4	RAT|RGD=2922|UniProtKB=P35570	Insulin receptor substrate 1	ISS	5031805	gi	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00049	Parkinson disease	P01227	20S proteasome	ORNAN|Ensembl=ENSOANG00000013220|UniProtKB=F6Z866	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF13	PROTEASOME SUBUNIT ALPHA TYPE-4
P00052	TGF-beta signaling pathway	P01284	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	176910	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000014574|UniProtKB=F7GRQ5	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF12	PROTOCADHERIN BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	RCA	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00906	Rap1	MACMU|Ensembl=ENSMMUG00000015779|UniProtKB=F7AWM6	Uncharacterized protein	ISS	8576107	PubMed	PTHR24070:SF194	RAS-RELATED PROTEIN RAP-2B
P00012	Cadherin signaling pathway	P00474	Wnt	DANRE|ZFIN=ZDB-GENE-081003-1|UniProtKB=B0LK22	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P00018	EGF receptor signaling pathway	P00551	Akt	CAEEL|WormBase=WBGene00000103|UniProtKB=Q9XTG7	Serine/threonine-protein kinase akt-2	ISS	12089061	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	HUMAN|HGNC=4383|UniProtKB=P30679	Guanine nucleotide-binding protein subunit alpha-15	IDA	11359849	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00018	EGF receptor signaling pathway	P00548	RKIP	ANOGA|EnsemblGenome=AGAP002049|UniProtKB=Q380S1	AGAP002049-PA	ISS			PTHR11362:SF28	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P00034	Integrin signalling pathway	P00912	Arp2/3	MOUSE|MGI=MGI=1915021|UniProtKB=Q9CPW4	Actin-related protein 2/3 complex subunit 5	ISS	10322212	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00025	Hedgehog signaling pathway	P00688	Hedgehog	STRPU|EnsemblGenome=SPU_012238|UniProtKB=W4Y925	Hedgehog protein	ISS			PTHR11889:SF31	PROTEIN HEDGEHOG
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	SCHPO|PomBase=SPAC10F6.03c|UniProtKB=O42644	CTP synthase	ISS			PTHR11550:SF0	CTP SYNTHASE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00036	Interleukin signaling pathway	P00964	p90RSK	HUMAN|HGNC=10430|UniProtKB=Q15418	Ribosomal protein S6 kinase alpha-1	ISS	7688567	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	TAS	11256888	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000001583|UniProtKB=F7BBM1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IGI	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00018	EGF receptor signaling pathway	P00551	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=3346|UniProtKB=P10688	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	10934033	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00059	p53 pathway	P04635	Sumo-1 ligase	MACMU|Ensembl=ENSMMUG00000029677|UniProtKB=F7G0L6	Small ubiquitin-related modifier	ISS			PTHR10562:SF11	SMALL UBIQUITIN-RELATED MODIFIER 2-RELATED
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MOUSE|MGI=MGI=1332242|UniProtKB=Q9Z304	Protein S-Myc	IEP	12356903	PubMed	PTHR11514:SF4	PROTEIN S-MYC
P00030	Hypoxia response via HIF activation	P00819	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	TAKRU|Ensembl=ENSTRUG00000014690|UniProtKB=H2UKR9	Uncharacterized protein	IDA	2039532	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	MONDO|Ensembl=ENSMODG00000018237|UniProtKB=F6PG65	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00019	Endothelin signaling pathway	P00589	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04553	PAK	BOVIN|Ensembl=ENSBTAG00000015670|UniProtKB=E1B7J7	Uncharacterized protein	ISS	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00017	DNA replication	P00527	Histones	PRIPA|Gene=PPA05646|UniProtKB=H3EZY8	Histone H3	ISS	20448842	PubMed	PTHR11426:SF169	HISTONE H3
P00036	Interleukin signaling pathway	P00975	RasGAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	ISS	88318957	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00005	Angiogenesis	P00186	FGFR-1	RAT|RGD=620713|UniProtKB=Q04589	Fibroblast growth factor receptor 1	ISS	9989949	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P00036	Interleukin signaling pathway	P00975	RasGAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DROME|FlyBase=FBgn0000489|UniProtKB=P16912	Protein kinase DC2	IC	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00009	Axon guidance mediated by netrin	P00366	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12676940	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CAEEL|WormBase=WBGene00000067|UniProtKB=O45815	ACTin	IC	3487386	PubMed	PTHR11937:SF352	ACTIN
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MONDO|Ensembl=ENSMODG00000004799|UniProtKB=F6VM87	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00627	ERK1-2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	9298898	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01171	PLCgamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04393	Ras Pathway	P04579	Shc	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	IDA	8264585	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P06587	Nicotine pharmacodynamics pathway	P06608	DDC	RAT|RGD=2494|UniProtKB=P14173	Aromatic-L-amino-acid decarboxylase	TAS	7567987	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CAEEL|WormBase=WBGene00001681|UniProtKB=P54406	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF3	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA-RELATED
P00010	B cell activation	P00398	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00367	NFAT	BOVIN|Ensembl=ENSBTAG00000018270|UniProtKB=F1MGR9	Uncharacterized protein	ISS	12787506	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00010	B cell activation	P00371	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00029	Huntington disease	P00774	Dynein complex	LEIMA|EnsemblGenome=LmjF.22.1110|UniProtKB=Q4QBN6	Putative dynein heavy chain, cytosolic	IPI	9454836	PubMed	PTHR10676:SF314	CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1
P00034	Integrin signalling pathway	P00936	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00790	beta-Tubulin	EMENI|EnsemblGenome=CADANIAG00001443|UniProtKB=P10653	Tubulin beta-1 chain	TAS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	IC	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00021	FGF signaling pathway	P00642	MEK1-2	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05915	Opioid proenkephalin pathway	P05994	G-protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00010	B cell activation	P00385	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	20010089	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00081	Pro-BACE-1	PANTR|Ensembl=ENSPTRG00000004324|UniProtKB=H2Q4U8	Beta-site APP-cleaving enzyme 1	ISS	10956649	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00047	PDGF signaling pathway	P01161	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00948	Rho	MOUSE|MGI=MGI=1338755|UniProtKB=Q9QYM5	Rho-related GTP-binding protein RhoN	ISS	11973360	PubMed	PTHR24072:SF21	RHO-RELATED GTP-BINDING PROTEIN RHON
P00049	Parkinson disease	P01211	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00951	Jnk	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	IDA	10207617	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	TAKRU|Ensembl=ENSTRUG00000012885|UniProtKB=H2U6T8	Uncharacterized protein (Fragment)	IDA	11781138	PubMed	PTHR24248:SF0	ALPHA-2DA ADRENERGIC RECEPTOR-RELATED
P00021	FGF signaling pathway	P00626	Spry	PANTR|Ensembl=ENSPTRG00000017360|UniProtKB=H2QRP3	Uncharacterized protein	ISS	99264295	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	ORNAN|Ensembl=ENSOANG00000013961|UniProtKB=F6VPY1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P05918	p38 MAPK pathway	P06034	MKK4	MONDO|Ensembl=ENSMODG00000008266|UniProtKB=F6Z879	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DROME|FlyBase=FBgn0001122|UniProtKB=P16378	G protein alpha o subunit	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	BOVIN|Ensembl=ENSBTAG00000019336|UniProtKB=F1MMW6	Uncharacterized protein	ISS	10409711	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	STRPU|Gene=CYIIIA|UniProtKB=P53474	Actin, cytoskeletal 3A	IC	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CANLF|Ensembl=ENSCAFG00000012623|UniProtKB=F1PVP1	Uncharacterized protein	ISS	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P04398	p53 pathway feedback loops 2	G04711	SIAH-1	MOUSE|MGI=MGI=108063|UniProtKB=Q06985	E3 ubiquitin-protein ligase SIAH1B	ISS	15326481	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	IC	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	ISS	20032362	PubMed	PTHR24055:SF330	SUBFAMILY NOT NAMED
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	ORNAN|Ensembl=ENSOANG00000003489|UniProtKB=F7FSE3	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00056	VEGF signaling pathway	P01407	Erk	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01292	RSmads	RAT|RGD=620158|UniProtKB=Q9R1V3	Mothers against decapentaplegic homolog 5	TAS	9395284	PubMed	PTHR13703:SF36	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5
P00057	Wnt signaling pathway	P01428	Frizzled	HUMAN|HGNC=4042|UniProtKB=Q9ULV1	Frizzled-4	IDA	8717036	PubMed	PTHR11309:SF23	FRIZZLED-4
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00005	Angiogenesis	P00238	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00583	cPLA2	PANTR|Ensembl=ENSPTRG00000001787|UniProtKB=H2Q0T0	Phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000008503|UniProtKB=F6TGJ6	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	ANOGA|EnsemblGenome=AGAP006475|UniProtKB=Q5TQX0	AGAP006475-PA	ISS	9065779	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	MOUSE|MGI=MGI=99460|UniProtKB=Q61982	Neurogenic locus notch homolog protein 3	IDA	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000010526|UniProtKB=F7B1S0	Uncharacterized protein	ISS			PTHR11824:SF7	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00057	Wnt signaling pathway	P01444	Wnt	TAKRU|Ensembl=ENSTRUG00000000172|UniProtKB=H2RJP1	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF103	PROTEIN WNT-4A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00718	Phosphorylase a	PANTR|Ensembl=ENSPTRG00000003845|UniProtKB=H2Q405	Alpha-1,4 glucan phosphorylase	ISS	4318782	PubMed	PTHR11468:SF13	GLYCOGEN PHOSPHORYLASE, MUSCLE FORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	BOVIN|Gene=CHRNA3|UniProtKB=Q07263	Neuronal acetylcholine receptor subunit alpha-3	IC	85270494	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P02756	N-acetylglucosamine metabolism	P03043	N-acetylglucosamine-1-phosphate uridyltransferase	BACSU|EnsemblGenome=BSU00500|UniProtKB=P14192	Bifunctional protein GlmU	ISS			PTHR43584:SF3	BIFUNCTIONAL PROTEIN GLMU
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00591	PLCbeta	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00017	DNA replication	P00530	Top	YEAST|SGD=S000005366|UniProtKB=P04786	DNA topoisomerase 1	RCA			PTHR10290:SF3	DNA TOPOISOMERASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000009900|UniProtKB=F1NHL1	Serine/threonine-protein kinase	ISS	12393506	PubMed	PTHR22968:SF9	SERINE/THREONINE-PROTEIN KINASE D1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04395	Vasopressin synthesis	P04589	Signal Peptidase	RAT|RGD=1311253|UniProtKB=D3ZD11	Protein Spcs2	ISS	2092035	PubMed	PTHR13085:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 2
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	PANTR|Ensembl=ENSPTRG00000012547|UniProtKB=H2QIU3	Uncharacterized protein	ISS	2433589	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00021	FGF signaling pathway	P00623	FGF	BOVIN|Gene=FGF18|UniProtKB=Q0VCA0	Fibroblast growth factor 18	ISS	12738892	PubMed	PTHR11486:SF4	FIBROBLAST GROWTH FACTOR 18
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00214	HIF-1	PANTR|Ensembl=ENSPTRG00000006419|UniProtKB=H2Q8F3	Uncharacterized protein	ISS	14526383	PubMed	PTHR23043:SF7	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02920	dCTP deaminase	CAEEL|WormBase=WBGene00012968|UniProtKB=Q9XXD0	Uncharacterized protein	ISS			PTHR44192:SF2	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04393	Ras Pathway	P04559	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	PANTR|Ensembl=ENSPTRG00000003957|UniProtKB=H2Q486	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00029	Huntington disease	P00796	Kainate receptor	RAT|RGD=2733|UniProtKB=P42260	Glutamate receptor ionotropic, kainate 2	IDA	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00054	Toll receptor signaling pathway	G01550	Gene trancription	MOUSE|MGI=MGI=107936|UniProtKB=P70380	Interleukin-18	ISS	22329004	PubMed	PTHR45200:SF1	INTERLEUKIN-18
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00047	PDGF signaling pathway	P01143	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05941	GRK3	TAKRU|Ensembl=ENSTRUG00000018612|UniProtKB=H2VEM3	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF18	PROTEIN-SERINE/THREONINE KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00049	Parkinson disease	P01242	Casein kinase I	BOVIN|Ensembl=ENSBTAG00000039794|UniProtKB=P35507	Casein kinase I isoform beta	IDA	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00012	Cadherin signaling pathway	P00474	Wnt	RAT|RGD=1307644|UniProtKB=D3ZND6	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00021	FGF signaling pathway	P00648	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00805	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00624	14-3-3	HUMAN|HGNC=12854|UniProtKB=P27348	14-3-3 protein theta	IPI	5803227	gi	PTHR18860:SF3	14-3-3 PROTEIN THETA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05730	Endogenous cannabinoid signaling	P05746	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00037	Ionotropic glutamate receptor pathway	P01020	NSF	HUMAN|HGNC=8016|UniProtKB=P46459	Vesicle-fusing ATPase	ISS	7969419	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	TAKRU|Ensembl=ENSTRUG00000011297|UniProtKB=H2TV18	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00057	Wnt signaling pathway	P01451	Galpha	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	IDA	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00010	B cell activation	P00383	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00004	Alzheimer disease-presenilin pathway	P00127	APP	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04393	Ras Pathway	P04542	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	HUMAN|HGNC=20754|UniProtKB=Q9HCX4	Short transient receptor potential channel 7	IDA	11055438	PubMed	PTHR10117:SF9	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 7
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	MACMU|Ensembl=ENSMMUG00000001387|UniProtKB=F7D0B4	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TRIAD|EnsemblGenome=TriadG63375|UniProtKB=B3S5E4	Non-muscle actin 6.2	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00018	EGF receptor signaling pathway	P00552	Ras	DAPPU|EnsemblGenome=DAPPUDRAFT_301818|UniProtKB=E9I1I7	Putative uncharacterized protein	ISS	10684567	PubMed	PTHR24070:SF385	GTPASE HRAS
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00029	Huntington disease	P00807	Actin	CANLF|Ensembl=ENSCAFG00000012181|UniProtKB=F2Z4N7	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IDA	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05915	Opioid proenkephalin pathway	P05994	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00048	PI3 kinase pathway	P01194	S6K	CHICK|Ensembl=ENSGALG00000005198|UniProtKB=F1P4J0	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ARATH|TAIR=AT3G18780|UniProtKB=Q96292	Actin-2	IC	11889126	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	DEIRA|EnsemblGenome=DR_2630|UniProtKB=Q9RR67	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	ORYSJ|EnsemblGenome=OS01G0872800|UniProtKB=Q8RUE8	Os01g0872800 protein	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00034	Integrin signalling pathway	P00944	Actin	MONDO|Ensembl=ENSMODG00000025373|UniProtKB=F6ZZG9	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00053	T cell activation	P01294	NFAT	MACMU|Ensembl=ENSMMUG00000022596|UniProtKB=F6Z7T2	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF5	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 1
P00034	Integrin signalling pathway	P00923	Arf1	DICDI|dictyBase=DDB_G0289173|UniProtKB=O00909	ADP-ribosylation factor 1	IPI	12932731	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00019	Endothelin signaling pathway	P00566	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01160	IP3 receptor	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P05915	Opioid proenkephalin pathway	P05994	G-protein	XENTR|Xenbase=XB-GENE-977853|UniProtKB=F7EBE7	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	HUMAN|HGNC=9509|UniProtKB=P49810	Presenilin-2	TAS	12846562	PubMed	PTHR10202:SF13	PRESENILIN-2
P00034	Integrin signalling pathway	P00936	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	RAT|RGD=2742|UniProtKB=P23385	Metabotropic glutamate receptor 1	IDA	12488551	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05916	Opioid prodynorphin pathway	P06002	G-protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00053	T cell activation	P01318	PKC-theta	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00012	Cadherin signaling pathway	P00477	GSK3beta	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00005	Angiogenesis	P00244	MAPKAPK2/3	PANTR|Ensembl=ENSPTRG00000001915|UniProtKB=H2Q104	Mitogen-activated protein kinase-activated protein kinase 2	ISS	7923354	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00029	Huntington disease	P00796	Kainate receptor	MOUSE|MGI=MGI=95816|UniProtKB=B1AS29	Glutamate receptor ionotropic, kainate 3	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00047	PDGF signaling pathway	P01159	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346347|UniProtKB=Q9WVS8	Mitogen-activated protein kinase 7	IDA	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P04393	Ras Pathway	P04542	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00056	VEGF signaling pathway	P01411	Ras	DICPU|Gene=DICPUDRAFT_51488|UniProtKB=F1A411	Putative uncharacterized protein rasC	ISS	8290260	PubMed	PTHR24070:SF251	RAS-LIKE PROTEIN RASC
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-478663|UniProtKB=F7EG64	Protein kinase C delta type	ISS	11880265	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04393	Ras Pathway	P04578	Rho	XENTR|Xenbase=XB-GENE-941426|UniProtKB=Q28HZ4	Novel Rho protein	ISS	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=96276|UniProtKB=Q61224	5-hydroxytryptamine receptor 1D	IDA	11701344	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00002	Alpha adrenergic receptor signaling pathway	P00078	Alpha1A/1B/1C	HUMAN|HGNC=282|UniProtKB=P18089	Alpha-2B adrenergic receptor	IC	11781138	PubMed	PTHR24248:SF26	ALPHA-2B ADRENERGIC RECEPTOR
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	PANTR|Ensembl=ENSPTRG00000007605|UniProtKB=H2QAA6	Nucleoside diphosphate kinase	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P00059	p53 pathway	P04609	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00060	Ubiquitin proteasome pathway	P01491	E2	MACMU|Ensembl=ENSMMUG00000005080|UniProtKB=F7C495	Uncharacterized protein	ISS			PTHR24067:SF3	UBIQUITIN-CONJUGATING ENZYME E2 G1
P00045	Notch signaling pathway	P01119	NIct	RAT|RGD=620761|UniProtKB=Q9R172	Neurogenic locus notch homolog protein 3	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00048	PI3 kinase pathway	P01196	PDK1	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	IGI	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=99841|UniProtKB=P32304	5-hydroxytryptamine receptor 7	IDA			PTHR24247:SF116	5-HYDROXYTRYPTAMINE RECEPTOR 7
P04393	Ras Pathway	P04567	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IDA	7565716	PubMed	PTHR10048:SF14	PI-3 KINASE
P00059	p53 pathway	P04623	CBP	BOVIN|Ensembl=ENSBTAG00000002920|UniProtKB=F1MFX5	Histone acetyltransferase	ISS	10769018	PubMed	PTHR10615:SF73	HISTONE ACETYLTRANSFERASE KAT6B
P00036	Interleukin signaling pathway	P00990	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00590	IP3 R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	MOUSE|MGI=MGI=3584516|UniProtKB=E9Q1T6	Protein Lrp3	ISS	11907044	PubMed	PTHR44062:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 3
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	HUMAN|HGNC=15814|UniProtKB=Q9NR19	Acetyl-coenzyme A synthetase, cytoplasmic	ISS			PTHR24095:SF126	ACETYL-COENZYME A SYNTHETASE, CYTOPLASMIC
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00971	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	10521483	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00049	Parkinson disease	P01212	p38 MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	HUMAN|HGNC=20869|UniProtKB=O95393	Bone morphogenetic protein 10	TAS	9759503	PubMed	PTHR11848:SF39	BONE MORPHOGENETIC PROTEIN 10
P00048	PI3 kinase pathway	P01192	p110	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00020	FAS signaling pathway	P00610	MKK4	MACMU|Ensembl=ENSMMUG00000019842|UniProtKB=F7FU91	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00010	B cell activation	P00388	PLC gamma2	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00056	VEGF signaling pathway	P01412	HSP27	CANLF|Ensembl=ENSCAFG00000023925|UniProtKB=E2RTA9	Uncharacterized protein	ISS			PTHR11527:SF163	HEAT SHOCK PROTEIN BETA-2
P04393	Ras Pathway	P04550	Ral	DANRE|ZFIN=ZDB-GENE-040801-267|UniProtKB=Q6DC92	Uncharacterized protein	ISS	12856001	PubMed	PTHR24070:SF199	RAS-RELATED PROTEIN RAL-B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00019	Endothelin signaling pathway	P00589	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06852	nPKCs	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	RCA	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00047	PDGF signaling pathway	P01167	Ets	MOUSE|MGI=MGI=107180|UniProtKB=Q60775	ETS-related transcription factor Elf-1	ISS	15298723	PubMed	PTHR11849:SF156	ETS-RELATED TRANSCRIPTION FACTOR ELF-1
P00019	Endothelin signaling pathway	P00566	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02771	Pyrimidine Metabolism	P03131	5'-Nucleotidase	HUMAN|HGNC=8021|UniProtKB=P21589	5'-nucleotidase	RCA	3219501	gi	PTHR11575:SF25	5'-NUCLEOTIDASE
P00022	General transcription by RNA polymerase I	P00652	RNA Polymerase I  Complex	MACMU|Ensembl=ENSMMUG00000020386|UniProtKB=G7NJU4	DNA-directed RNA polymerases I and III subunit RPAC2	ISS	12446911	PubMed	PTHR13946:SF28	DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00565	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00012	Cadherin signaling pathway	P00474	Wnt	MONDO|Ensembl=ENSMODG00000001196|UniProtKB=F7GH85	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00737	Rap1GAP	HUMAN|HGNC=9858|UniProtKB=P47736	Rap1 GTPase-activating protein 1	IDA	10419452	PubMed	PTHR15711:SF3	RAP1 GTPASE-ACTIVATING PROTEIN 1
P00059	p53 pathway	P04612	HDAC1	BOVIN|Ensembl=ENSBTAG00000012698|UniProtKB=Q32PJ8	Histone deacetylase 1	ISS	10485845	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CANLF|Ensembl=ENSCAFG00000012623|UniProtKB=F1PVP1	Uncharacterized protein	ISS	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00054	Toll receptor signaling pathway	P01375	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MOUSE|MGI=MGI=96571|UniProtKB=Q04999	Inhibin beta B chain	ISS	11451570	PubMed	PTHR11848:SF29	INHIBIN BETA B CHAIN
P00034	Integrin signalling pathway	P00920	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-2280|UniProtKB=Q6P025	Gnb3 protein	ISS			PTHR19850:SF35	GNB3 PROTEIN
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	PANTR|Ensembl=ENSPTRG00000013147|UniProtKB=H2QJS7	Uncharacterized protein	ISS	10617630	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00010	B cell activation	P00376	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IGI	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346347|UniProtKB=Q9WVS8	Mitogen-activated protein kinase 7	IDA	12912994	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00052	TGF-beta signaling pathway	P01286	TGFbeta	RAT|RGD=69051|UniProtKB=P17246	Transforming growth factor beta-1	TAS	9759503	PubMed	PTHR11848:SF125	TRANSFORMING GROWTH FACTOR BETA-1
P00034	Integrin signalling pathway	P00951	Jnk	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IDA	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05913	Enkephalin release	P05972	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00790	beta-Tubulin	MOUSE|MGI=MGI=1915472|UniProtKB=P68372	Tubulin beta-4B chain	TAS	12932731	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00036	Interleukin signaling pathway	P00964	p90RSK	CHICK|Ensembl=ENSGALG00000016406|UniProtKB=F1NLJ3	Uncharacterized protein	ISS	2779569	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000023940|UniProtKB=F6RFW8	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00005	Angiogenesis	P00185	JAK1	MACMU|Ensembl=ENSMMUG00000018566|UniProtKB=F6YLX1	Tyrosine-protein kinase	ISS	11929133	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P02732	Coenzyme A linked carnitine metabolism	P02864	L-carnitine dehydratase	MYCTU|EnsemblGenome=P425_01930|UniProtKB=P95149	Probable CoA-transferase Rv1866	ISS			PTHR43949:SF1	ACETYL-COA:OXALATE COA-TRANSFERASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	NEUCR|EnsemblGenome=EFNCRG00000003957|UniProtKB=V5ILY7	Protein kinase gsk3	ISS	11995474	gi	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	XENTR|Xenbase=XB-GENE-963560|UniProtKB=Q0VFC4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00048	PI3 kinase pathway	P01192	p110	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01181	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IPI	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00321	HSP70	YEAST|SGD=S000003571|UniProtKB=P16474	78 kDa glucose-regulated protein homolog	ISS	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	PANTR|Ensembl=ENSPTRG00000013825|UniProtKB=H2RAK4	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	RAT|RGD=2722|UniProtKB=P00507	Aspartate aminotransferase, mitochondrial	ISS			PTHR11879:SF32	ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	PANTR|Ensembl=ENSPTRG00000020739|UniProtKB=H2R6U6	Solute carrier family 1 (Neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	ISS	96032356	PubMed	PTHR11958:SF69	EXCITATORY AMINO ACID TRANSPORTER 3
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00624	14-3-3	RAT|RGD=62000|UniProtKB=P62260	14-3-3 protein epsilon	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P02770	Pyridoxal phosphate salvage pathway	P03121	Pyridoxal kinase	PANTR|Ensembl=ENSPTRG00000040962|UniProtKB=H2RGH3	Pyridoxal (Pyridoxine, vitamin B6) kinase	ISS	15082224	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00985	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04393	Ras Pathway	P04546	GSK3	CANLF|Ensembl=ENSCAFG00000004882|UniProtKB=F1PAE3	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00011	Blood coagulation	P00410	GP IIb	RAT|RGD=1596428|UniProtKB=D3ZAC0	Protein Itga2b	ISS	281055	gi	PTHR23220:SF73	INTEGRIN ALPHA-IIB
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00019	Endothelin signaling pathway	P00587	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MONDO|Ensembl=ENSMODG00000023942|UniProtKB=F7F878	Uncharacterized protein	ISS	12562507	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P00029	Huntington disease	P00780	Microtubule	CHICK|GeneID=431043|UniProtKB=P09652	Tubulin beta-4 chain	IDA	9454836	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00021	FGF signaling pathway	P00638	PLCgamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00046	Oxidative stress response	P01131	MKP5	MOUSE|MGI=MGI=1891150|UniProtKB=Q60969	Serine/threonine/tyrosine-interacting protein	ISS			PTHR10159:SF385	SERINE/THREONINE/TYROSINE-INTERACTING PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	TAS	10207617	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01352	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00029	Huntington disease	P00796	Kainate receptor	CANLF|Ensembl=ENSCAFG00000004930|UniProtKB=E2RFB5	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P02752	Mannose metabolism	P03018	Mannose 1-P guanylyl transferase	HUMAN|HGNC=22932|UniProtKB=Q9Y5P6	Mannose-1-phosphate guanyltransferase beta	IDA	11082198	PubMed	PTHR22572:SF15	MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE BETA
P04393	Ras Pathway	P04570	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05731	GABA-B receptor II signaling	P05754	Ggamma	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	RCA	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00008	Axon guidance mediated by Slit/Robo	P00344	Netrin	MACMU|Ensembl=ENSMMUG00000009397|UniProtKB=F7HEU6	Uncharacterized protein	ISS	9427245	PubMed	PTHR10574:SF365	NETRIN-1
P00053	T cell activation	P01304	Csk	MONDO|Ensembl=ENSMODG00000009310|UniProtKB=F7GJZ7	Tyrosine-protein kinase	ISS	12665526	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=96283|UniProtKB=P30966	5-hydroxytryptamine receptor 5A	IDA	12441358	PubMed	PTHR24247:SF108	5-HYDROXYTRYPTAMINE RECEPTOR 5A
P00019	Endothelin signaling pathway	P00590	IP3 R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00551	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IDA	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00029	Huntington disease	P00807	Actin	MACMU|Ensembl=ENSMMUG00000012054|UniProtKB=F6TII3	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P04392	P53 pathway feedback loops 1	P04539	p53	MACMU|Ensembl=ENSMMUG00000008639|UniProtKB=P56424	Cellular tumor antigen p53	TAS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00003	Alzheimer disease-amyloid secretase pathway	P00093	Tip60	MONDO|Ensembl=ENSMODG00000009581|UniProtKB=F7AWF2	Histone acetyltransferase	ISS	11441186	PubMed	PTHR10615:SF124	HISTONE ACETYLTRANSFERASE KAT5
P00018	EGF receptor signaling pathway	P00555	MKK4,7	MACMU|Ensembl=ENSMMUG00000019842|UniProtKB=F7FU91	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-478663|UniProtKB=F7EG64	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00019	Endothelin signaling pathway	P00586	Gq	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00030	Hypoxia response via HIF activation	P00819	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	TAS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00005	Angiogenesis	P00206	Wnt	BOVIN|Ensembl=ENSBTAG00000020221|UniProtKB=E1BDG5	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00019	Endothelin signaling pathway	P00589	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01179	PKB	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	BOVIN|Ensembl=ENSBTAG00000016198|UniProtKB=E1B8D6	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00021	FGF signaling pathway	P00645	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	MOUSE|MGI=MGI=1920431|UniProtKB=Q8K120	Nuclear factor of activated T-cells, cytoplasmic 4	ISS	12787506	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	CANLF|Ensembl=ENSCAFG00000004882|UniProtKB=F1PAE3	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00029	Huntington disease	P00807	Actin	DROME|FlyBase=FBgn0000046|UniProtKB=P10981	Actin-87E	IDA	10974003	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00047	PDGF signaling pathway	P01152	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	2842690	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01465	Ggamma	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00029	Huntington disease	P00792	SEK-1	RAT|RGD=1307040|UniProtKB=F1LP57	Protein Map2k4	RCA			PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00010	B cell activation	P00375	Calmodulin	ARATH|TAIR=AT3G43810|UniProtKB=P59220	Calmodulin-7	ISS	7514101	PubMed	PTHR23050:SF250	CALMODULIN-7
P00005	Angiogenesis	P00235	c-Fos	MONDO|Ensembl=ENSMODG00000005927|UniProtKB=F6WX28	Uncharacterized protein	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00021	FGF signaling pathway	P00629	PP2A	BOVIN|Ensembl=ENSBTAG00000020598|UniProtKB=F1MY94	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B	ISS	7918404	PubMed	PTHR11871:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B GAMMA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=268|UniProtKB=P0DMS8	Adenosine receptor A3	IDA	12515326	PubMed	PTHR24246:SF2	ADENOSINE RECEPTOR A3
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	HUMAN|HGNC=2453|UniProtKB=P49674	Casein kinase I isoform epsilon	ISS	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00022	General transcription by RNA polymerase I	P00652	RNA Polymerase I  Complex	YEAST|SGD=S000005057|UniProtKB=P28000	DNA-directed RNA polymerases I and III subunit RPAC2	ISS			PTHR13946:SF28	DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00556	PLCgamma	CANAL|CGD=CAL0006065|UniProtKB=Q59LC4	Phosphoinositide phospholipase C	IC			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00012	Cadherin signaling pathway	P00474	Wnt	CHICK|Ensembl=ENSGALG00000005410|UniProtKB=Q9YGX6	Protein Wnt	IDA	11266476	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P05915	Opioid proenkephalin pathway	P05994	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04393	Ras Pathway	P04567	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	DROME|FlyBase=FBgn0087012|UniProtKB=Q8IPN2	5-hydroxytryptamine (Serotonin) receptor 2A, isoform B	ISS	12181435	PubMed	PTHR24247:SF125	5-HYDROXYTRYPTAMINE  SEROTONIN  RECEPTOR 2A, ISOFORM B
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	10218114	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	RAT|RGD=3763|UniProtKB=P30680	Somatostatin receptor type 2	IDA			PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	ISS	8457205	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04580	TRH Receptor	MOUSE|MGI=MGI=2177284|UniProtKB=Q9ERT2	Protein Trhr2	ISS			PTHR24243:SF51	PROTEIN TRHR2
P00004	Alzheimer disease-presenilin pathway	P00165	E-cadherin N-terminal fragment	RAT|RGD=69279|UniProtKB=Q9R0T4	Cadherin-1	TAS	12834808	PubMed	PTHR24027:SF319	CADHERIN-1
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PUCGT|EnsemblGenome=PGTG_05488|UniProtKB=E3K4I1	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	P01444	Wnt	RAT|RGD=1305018|UniProtKB=D3ZF63	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	HUMAN|HGNC=19663|UniProtKB=Q9UBI6	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IDA	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00029	Huntington disease	P00786	ARF	BOVIN|Ensembl=ENSBTAG00000016069|UniProtKB=Q3SZF2	ADP-ribosylation factor 4	ISS	12932731	PubMed	PTHR11711:SF110	ADP-RIBOSYLATION FACTOR 4
P00012	Cadherin signaling pathway	P00470	F-actin	HUMAN|HGNC=132|UniProtKB=P60709	Actin, cytoplasmic 1	IC	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00030	Hypoxia response via HIF activation	P00819	AKT	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	TAS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	SULSO|EnsemblGenome=SSO0946|UniProtKB=P58110	Transcription initiation factor IIB 2	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	PANTR|Ensembl=ENSPTRG00000001790|UniProtKB=H2Q0T3	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF34	REGULATOR OF G-PROTEIN SIGNALING 1
P00012	Cadherin signaling pathway	P00462	Casein kinase II	XENTR|Xenbase=XB-GENE-487069|UniProtKB=F6RN85	Uncharacterized protein	ISS	10617630	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	RAT|RGD=3425|UniProtKB=P97887	Presenilin-1	IDA	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00053	T cell activation	P01312	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IDA	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04393	Ras Pathway	P04548	ATF2	CANLF|Ensembl=ENSCAFG00000013332|UniProtKB=F1PCQ4	Uncharacterized protein	ISS	10487205	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00005	Angiogenesis	P00243	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=11433|UniProtKB=Q16623	Syntaxin-1A	ISS	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00006	Apoptosis signaling pathway	P00274	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00022	General transcription by RNA polymerase I	P00657	TBP	CANLF|Ensembl=ENSCAFG00000004119|UniProtKB=F1PQA5	Uncharacterized protein	ISS	600075	OMIM	PTHR10126:SF20	TATA-BOX-BINDING PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=107451|UniProtKB=Q8K2J0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3	ISS	15611108	PubMed	PTHR10336:SF33	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-3
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00045	Notch signaling pathway	P01106	Mastermind	MACMU|Ensembl=ENSMMUG00000012371|UniProtKB=F7EF97	Uncharacterized protein	ISS	12644465	PubMed	PTHR15692:SF19	MASTERMIND-LIKE PROTEIN 1
P00018	EGF receptor signaling pathway	P00560	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01129	JNK1/2	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00047	PDGF signaling pathway	P01143	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	YEAST|SGD=S000005854|UniProtKB=P33328	Synaptobrevin homolog 2	IC			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000021437|UniProtKB=H2QXZ6	Uncharacterized protein	ISS	11554554	PubMed	PTHR24356:SF175	SERINE/THREONINE-PROTEIN KINASE N3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00778	NMDA receptor	MOUSE|MGI=MGI=1933206|UniProtKB=A2AIR5	Protein Grin3a	ISS	11554549	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00057	Wnt signaling pathway	P01472	Histone deacetylase	XENTR|Xenbase=XB-GENE-485807|UniProtKB=F6VWX1	Histone deacetylase	ISS	10485845	PubMed	PTHR10625:SF171	HISTONE DEACETYLASE 2
P04398	p53 pathway feedback loops 2	P04651	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	HUMAN|HGNC=1404|UniProtKB=O00305	Voltage-dependent L-type calcium channel subunit beta-4	IC			PTHR11824:SF7	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00056	VEGF signaling pathway	P01402	MEK	BOVIN|Ensembl=ENSBTAG00000005865|UniProtKB=G5E577	Uncharacterized protein	ISS			PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00057	Wnt signaling pathway	P01428	Frizzled	BOVIN|Ensembl=ENSBTAG00000007047|UniProtKB=A3KMX5	FZD10 protein	ISS	8717036	PubMed	PTHR11309:SF86	FRIZZLED-10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00052	TGF-beta signaling pathway	P01284	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	TAS	7600581	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P02738	De novo purine biosynthesis	P02898	Phosphoribosylformylglycinamide  synthase	FUSNN|EnsemblGenome=FN0990|UniProtKB=Q8REU9	Phosphoribosylformylglycinamidine synthase	ISS			PTHR10099:SF1	PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01156	PDGF receptor B	MOUSE|MGI=MGI=1916047|UniProtKB=Q6PE55	Platelet-derived growth factor receptor-like protein	ISS			PTHR15360:SF1	PLATELET-DERIVED GROWTH FACTOR RECEPTOR-LIKE PROTEIN
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00019	Endothelin signaling pathway	P00586	Gq	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05734	Synaptic vesicle trafficking	P05779	Synaptobrevin	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IDA	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	BACSU|EnsemblGenome=BSU18480|UniProtKB=P0CI77	Pyrroline-5-carboxylate reductase 1	ISS			PTHR11645:SF0	PYRROLINE-5-CARBOXYLATE REDUCTASE
P00047	PDGF signaling pathway	P01155	Jak	RAT|RGD=2939|UniProtKB=Q62689	Tyrosine-protein kinase JAK2	ISS	22482294	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P05913	Enkephalin release	P05972	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00018	EGF receptor signaling pathway	P00559	MEK1-2	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00049	Parkinson disease	P01238	14-3-3	BOVIN|Gene=YWHAB|UniProtKB=P68250	14-3-3 protein beta/alpha	IDA	1671102	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01078	VAChT	DROME|FlyBase=FBgn0043005|UniProtKB=Q9VCJ5	Portabella	IC	21863848	PubMed	PTHR23506:SF4	PORTABELLA
P00021	FGF signaling pathway	P00645	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_94959|UniProtKB=C3XYC4	Putative uncharacterized protein	IDA	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	DEIRA|EnsemblGenome=DR_2374|UniProtKB=Q9RRW1	Ribonucleoside-diphosphate reductase	ISS			PTHR43371:SF1	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01286	TGFbeta	HUMAN|HGNC=4221|UniProtKB=Q6KF10	Growth/differentiation factor 6	TAS	9759503	PubMed	PTHR11848:SF43	GROWTH/DIFFERENTIATION FACTOR 6
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00054	Toll receptor signaling pathway	P01380	TLR1,2,6	MACMU|Ensembl=ENSMMUG00000002418|UniProtKB=F6PP64	Toll-like receptor	ISS			PTHR24365:SF422	TOLL-LIKE RECEPTOR 6
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01173	STAT	MONDO|Ensembl=ENSMODG00000028212|UniProtKB=F7BYN4	Signal transducer and activator of transcription	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P05731	GABA-B receptor II signaling	P05754	Ggamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00010	B cell activation	P00375	Calmodulin	MONDO|Ensembl=ENSMODG00000004410|UniProtKB=F6SV58	Uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF322	SUBFAMILY NOT NAMED
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04558	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00057	Wnt signaling pathway	P01465	Ggamma	MONDO|Ensembl=ENSMODG00000016895|UniProtKB=F6XII5	Uncharacterized protein	ISS	10391901	PubMed	PTHR15936:SF2	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-13
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	IDA	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05913	Enkephalin release	P05974	G-Protein (i)	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00035	Interferon-gamma signaling pathway	P00956	SOCS	CHICK|Gene=CISH|UniProtKB=Q9PW70	Cytokine-inducible SH2-containing protein	TAS	15032587	PubMed	PTHR44649:SF1	CYTOKINE-INDUCIBLE SH2-CONTAINING PROTEIN
P05913	Enkephalin release	P05977	G-Protein (s)	DANRE|ZFIN=ZDB-GENE-030131-9966|UniProtKB=Q6TH03	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00037	Ionotropic glutamate receptor pathway	P01023	CaMKII	HUMAN|HGNC=1461|UniProtKB=Q13554	Calcium/calmodulin-dependent protein kinase type II subunit beta	ISS	12888804	PubMed	PTHR43940:SF3	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT BETA
P02728	Arginine biosynthesis	P02841	argininosuccinate lyase	SYNY3|EnsemblGenome=BAA17284|UniProtKB=P73257	Argininosuccinate lyase	ISS			PTHR43814:SF1	ARGININOSUCCINATE LYASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00052	TGF-beta signaling pathway	P01284	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04393	Ras Pathway	P04567	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00005	Angiogenesis	P00254	GTPase	DANRE|ZFIN=ZDB-GENE-040426-2150|UniProtKB=Q6NUX8	Rho-related GTP-binding protein RhoA-A	ISS	12024019	PubMed	PTHR24072:SF260	RHO-RELATED GTP-BINDING PROTEIN RHOA-A-RELATED
P04392	P53 pathway feedback loops 1	P04537	p73DeltaN	MACMU|Ensembl=ENSMMUG00000016466|UniProtKB=F7GBH1	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	11313908	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00048	PI3 kinase pathway	P01199	Galpha	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	IC	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00047	PDGF signaling pathway	P01160	IP3 receptor	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00059	p53 pathway	G04704	KAI	MOUSE|MGI=MGI=104651|UniProtKB=P40237	CD82 antigen	ISS			PTHR19282:SF44	CD82 ANTIGEN
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000019277|UniProtKB=H2QUQ1	Uncharacterized protein	ISS	1321498	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P04398	p53 pathway feedback loops 2	P04665	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000025373|UniProtKB=F6ZZG9	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00021	FGF signaling pathway	P00624	14-3-3	BOVIN|Ensembl=ENSBTAG00000005664|UniProtKB=P62261	14-3-3 protein epsilon	ISS	9450960	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00060	Ubiquitin proteasome pathway	P01490	E3	HUMAN|HGNC=12469|UniProtKB=P22314	Ubiquitin-like modifier-activating enzyme 1	ISS			PTHR10953:SF155	UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 1
P00047	PDGF signaling pathway	P01153	GSK3	RAT|RGD=620351|UniProtKB=P18265	Glycogen synthase kinase-3 alpha	ISS	12086949	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P06664	Gonadotropin-releasing hormone receptor pathway	P06717	gnas	MOUSE|MGI=MGI=95777|UniProtKB=Q6R0H7	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas	RCA	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000009939|UniProtKB=H2QED9	Cadherin 2, type 1, N-cadherin (Neuronal)	ISS	8120095	PubMed	PTHR24027:SF79	CADHERIN-2
P04393	Ras Pathway	P04546	GSK3	RAT|RGD=620351|UniProtKB=P18265	Glycogen synthase kinase-3 alpha	IDA	21361340	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P04393	Ras Pathway	P04542	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00046	Oxidative stress response	P01122	TRX	CHICK|Ensembl=ENSGALG00000015704|UniProtKB=P08629	Thioredoxin	TAS	12115731	PubMed	PTHR10438:SF18	THIOREDOXIN
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P02770	Pyridoxal phosphate salvage pathway	P03123	Pyridoxine-5-phosphate oxidase	PSEAE|EnsemblGenome=PA1049|UniProtKB=Q9I4S5	Pyridoxine/pyridoxamine 5'-phosphate oxidase	ISS	10984043	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00036	Interleukin signaling pathway	P00985	PDK1/2	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IGI	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00019	Endothelin signaling pathway	P00586	Gq	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00017	DNA replication	P00527	Histones	CAEEL|WormBase=WBGene00012276|UniProtKB=Q27532	Histone H3.3-like type 2	ISS	12413958	PubMed	PTHR11426:SF118	HISTONE H3.3 TYPE 2-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	DANRE|ZFIN=ZDB-GENE-030616-382|UniProtKB=B5LZ08	Protein-serine/threonine kinase	ISS	10852916	PubMed	PTHR24355:SF18	PROTEIN-SERINE/THREONINE KINASE
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00629	PP2A	CANLF|Ensembl=ENSCAFG00000006453|UniProtKB=F6X958	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	HUMAN|HGNC=4597|UniProtKB=P41594	Metabotropic glutamate receptor 5	ISS	14614461	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00049	Parkinson disease	P01227	20S proteasome	DROME|FlyBase=FBgn0261395|UniProtKB=Q9VA12	Proteasome subunit alpha type-4-like	TAS	12859888	PubMed	PTHR11599:SF13	PROTEASOME SUBUNIT ALPHA TYPE-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01443	Phospholipase C	ANOGA|Gene=AgaP_AGAP009115|UniProtKB=Q7PW25	Phosphoinositide phospholipase C (Fragment)	ISS	1707501	PubMed	PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00047	PDGF signaling pathway	P01143	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00546	GAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	IGI	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	RAT|RGD=1596945|UniProtKB=F1M1C9	Protein Phka2	ISS	10487978	PubMed	PTHR10749:SF5	PHOSPHORYLASE B KINASE REGULATORY SUBUNIT ALPHA, LIVER ISOFORM
P00052	TGF-beta signaling pathway	P01286	TGFbeta	HUMAN|HGNC=30142|UniProtKB=Q99988	Growth/differentiation factor 15	TAS	9326641	PubMed	PTHR11848:SF78	GROWTH/DIFFERENTIATION FACTOR 15
P05734	Synaptic vesicle trafficking	P05779	Synaptobrevin	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IDA	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00029	Huntington disease	P00788	Calpain	CANLF|Ensembl=ENSCAFG00000006029|UniProtKB=E2R0F7	Uncharacterized protein	ISS	11675509	PubMed	PTHR10183:SF22	CALPAIN-7
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05913	Enkephalin release	P05974	G-Protein (i)	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04398	p53 pathway feedback loops 2	G04711	SIAH-1	RAT|RGD=620449|UniProtKB=Q920M9	E3 ubiquitin-protein ligase SIAH1	ISS	14985507	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00059	p53 pathway	P04609	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	ISS	10799299	PubMed	PTHR10048:SF14	PI-3 KINASE
P00054	Toll receptor signaling pathway	P01356	ERK2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00632	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347740|UniProtKB=E9FXV8	Cytoplasmatic actin	ISS	14684598	PubMed	PTHR11937:SF277	SUBFAMILY NOT NAMED
P06587	Nicotine pharmacodynamics pathway	P06593	CHRNA5	MONDO|Ensembl=ENSMODG00000011857|UniProtKB=F7GDB2	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF76	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5
P05731	GABA-B receptor II signaling	P05752	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MONDO|Ensembl=ENSMODG00000018065|UniProtKB=F7G485	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00896	Insulin IGF	MOUSE|MGI=MGI=96432|UniProtKB=P05017	Insulin-like growth factor I	ISS			PTHR11454:SF4	INSULIN-LIKE GROWTH FACTOR I
P00019	Endothelin signaling pathway	P00574	Big ET1-4	PANTR|Ensembl=ENSPTRG00000017730|UniProtKB=H2QSB1	Uncharacterized protein	ISS	12907686	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P02728	Arginine biosynthesis	P02841	argininosuccinate lyase	DEIRA|EnsemblGenome=DR_0678|UniProtKB=Q9RWJ0	Argininosuccinate lyase	ISS			PTHR43814:SF1	ARGININOSUCCINATE LYASE
P00010	B cell activation	P00371	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	ISS	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P06587	Nicotine pharmacodynamics pathway	P06601	FLNA	BOVIN|Ensembl=ENSBTAG00000011190|UniProtKB=F1N169	Uncharacterized protein	ISS	11911837	PubMed	PTHR43998:SF6	FILAMIN-A
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01160	IP3 receptor	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CHICK|Gene=ACTA2|UniProtKB=P08023	Actin, aortic smooth muscle	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00057	Wnt signaling pathway	P01447	Dishevelled	RAT|RGD=1309725|UniProtKB=D3ZB71	Protein Dvl2	ISS	11212302	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	CHICK|Ensembl=ENSGALG00000007039|UniProtKB=F1NG99	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P02777	Succinate to proprionate conversion	P03161	Methylmalonyl-CoA mutase	HUMAN|HGNC=7526|UniProtKB=P22033	Methylmalonyl-CoA mutase, mitochondrial	ISS			PTHR42710:SF1	METHYLMALONYL-COA MUTASE, MITOCHONDRIAL
P00005	Angiogenesis	P00223	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00391	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01452	NFAT	HUMAN|HGNC=7776|UniProtKB=Q13469	Nuclear factor of activated T-cells, cytoplasmic 2	IDA	9133421	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	HALSA|EnsemblGenome=VNG_1160G|UniProtKB=P61136	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00034	Integrin signalling pathway	P00924	Raf	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	MONDO|Ensembl=ENSMODG00000001775|UniProtKB=F6WJB1	Uncharacterized protein	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P05913	Enkephalin release	P05972	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	10477300	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	ORYSJ|EnsemblGenome=OS02G0735200|UniProtKB=P14656	Glutamine synthetase cytosolic isozyme 1-1	ISS			PTHR20852:SF79	GLUTAMINE SYNTHETASE CYTOSOLIC ISOZYME 1-1-RELATED
P00053	T cell activation	P01300	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00775	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00572	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	TAS	97442349	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	MOUSE|MGI=MGI=95576|UniProtKB=P48760	Folylpolyglutamate synthase, mitochondrial	ISS			PTHR11136:SF5	FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL
P00021	FGF signaling pathway	P00629	PP2A	XENTR|Xenbase=XB-GENE-957248|UniProtKB=Q6GLE6	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	MOUSE|MGI=MGI=98180|UniProtKB=P07742	Ribonucleoside-diphosphate reductase large subunit	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	XENTR|Xenbase=XB-GENE-494200|UniProtKB=F7CS79	Uncharacterized protein	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04393	Ras Pathway	P04559	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00050	Plasminogen activating cascade	P01246	Plasmin	RAT|RGD=619893|UniProtKB=Q01177	Plasminogen	ISS	11928811	PubMed	PTHR24261:SF5	PLASMINOGEN
P00037	Ionotropic glutamate receptor pathway	P01026	KA	CANLF|Ensembl=ENSCAFG00000003333|UniProtKB=F1PWT6	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00053	T cell activation	P01311	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01187	IR	HUMAN|HGNC=6091|UniProtKB=P06213	Insulin receptor	ISS	6754360	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00047	PDGF signaling pathway	P01161	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	TAS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00034	Integrin signalling pathway	P00942	Fyn	HUMAN|HGNC=4037|UniProtKB=P06241	Tyrosine-protein kinase Fyn	IPI	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00048	PI3 kinase pathway	P01199	Galpha	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	IDA	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00005	Angiogenesis	P00182	p38MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	PANTR|Gene=HTR2C|UniProtKB=Q5IS66	5-hydroxytryptamine receptor 2C	ISS	11859080	PubMed	PTHR24247:SF32	5-HYDROXYTRYPTAMINE RECEPTOR 2C
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00807	Actin	ORYSJ|EnsemblGenome=OS11G0163100|UniProtKB=Q67G20	Actin	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P04397	p53 pathway by glucose deprivation	P04641	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01300	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01238	14-3-3	TAKRU|Ensembl=ENSTRUG00000004697|UniProtKB=H2SFG7	Uncharacterized protein	ISS	9507245	gi	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	ORNAN|Ensembl=ENSOANG00000013961|UniProtKB=F6VPY1	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000012922|UniProtKB=H2QJF2	Phosphoinositide phospholipase C	ISS			PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=1309999|UniProtKB=Q922R0	cAMP-dependent protein kinase catalytic subunit PRKX	IC	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P05918	p38 MAPK pathway	P06021	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00049	Parkinson disease	P01208	Hsp70	ORYSJ|EnsemblGenome=OS03G0821100|UniProtKB=Q84TA1	Heat shock cognate 70 kDa protein 2, putative, expressed	IDA	12150907	PubMed	PTHR19375:SF327	SUBFAMILY NOT NAMED
P00053	T cell activation	P01332	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IDA	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000007084|UniProtKB=H2Q9G5	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00021	FGF signaling pathway	P00644	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00006	Apoptosis signaling pathway	P00315	RIP	HUMAN|HGNC=10019|UniProtKB=Q13546	Receptor-interacting serine/threonine-protein kinase 1	IDA	7538908	PubMed	PTHR44738:SF1	RECEPTOR-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00591	PLCbeta	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	RAT|RGD=2026|UniProtKB=P68035	Actin, alpha cardiac muscle 1	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00049	Parkinson disease	P01242	Casein kinase I	HUMAN|HGNC=2453|UniProtKB=P49674	Casein kinase I isoform epsilon	IDA	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P04375	5HT3 type receptor mediated signaling pathway	P04421	5HT transporter	RAT|RGD=3714|UniProtKB=P31652	Sodium-dependent serotonin transporter	ISS	14653308	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04397	p53 pathway by glucose deprivation	P04641	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00060	Ubiquitin proteasome pathway	P01491	E2	RAT|RGD=1305644|UniProtKB=D3ZYE1	Protein Ube2e2	ISS			PTHR24068:SF62	UBIQUITIN-CONJUGATING ENZYME E2 E2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	TAKRU|Ensembl=ENSTRUG00000016954|UniProtKB=H2V2J5	Uncharacterized protein	ISS	15226293	PubMed	PTHR13715:SF99	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04665	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00001	Adrenaline and noradrenaline biosynthesis	P00068	amine translocator	DROME|Gene=CG43066|UniProtKB=A0A0B4K7V4	Transporter	IC	12719981	PubMed	PTHR11616:SF187	TRANSPORTER
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00048	PI3 kinase pathway	P01188	Gbetagamma	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00047	PDGF signaling pathway	P01143	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00916	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00021	FGF signaling pathway	P00648	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	10747026	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04392	P53 pathway feedback loops 1	G04685	p73DeltaN	PANTR|Ensembl=ENSPTRG00000015733|UniProtKB=H2QNY5	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	IC	2372396	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00545	JNK1-3	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00551	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IGI	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00053	T cell activation	P01324	rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00034	Integrin signalling pathway	P00943	Talin	CANLF|Ensembl=ENSCAFG00000002154|UniProtKB=F1PSC2	Uncharacterized protein	ISS	14702644	PubMed	PTHR19981:SF7	MESODERM DEVELOPMENT CANDIDATE 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P02778	Sulfate assimilation	P03164	Adenylylsulfate kinase	ARATH|TAIR=AT5G67520|UniProtKB=Q84JF0	Adenylyl-sulfate kinase 4, chloroplastic	ISS			PTHR11055:SF1	PAPS SYNTHETASE, ISOFORM D
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00005	Angiogenesis	P00188	Ets	MOUSE|MGI=MGI=95455|UniProtKB=P27577	Protein C-ets-1	ISS	3060801	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	RCA			PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00222	VEGFR-2	MACMU|Ensembl=ENSMMUG00000012669|UniProtKB=F7E313	Uncharacterized protein	ISS	11221852	PubMed	PTHR24416:SF45	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2
P00049	Parkinson disease	P01230	Src kinase	DROME|FlyBase=FBgn0262733|UniProtKB=P00528	Tyrosine-protein kinase Src64B	IDA	11078745	PubMed	PTHR24418:SF283	TYROSINE-PROTEIN KINASE SRC64B
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00021	FGF signaling pathway	P00648	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	15572354	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	IC	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	XENTR|Xenbase=XB-GENE-961764|UniProtKB=F6W3Y0	Uncharacterized protein	ISS	7559398	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00057	Wnt signaling pathway	P01438	PP2A	MACMU|Ensembl=ENSMMUG00000013047|UniProtKB=F7H808	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01151	PKB	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06831	p38	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	RCA	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00005	Angiogenesis	P00253	Axin	MOUSE|MGI=MGI=1270862|UniProtKB=O88566	Axin-2	ISS	9554852	PubMed	PTHR10845:SF103	AXIN-2
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MACMU|Ensembl=ENSMMUG00000021442|UniProtKB=F7EAQ8	Muscarinic acetylcholine receptor	ISS	11166329	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DICDI|dictyBase=DDB_G0279413|UniProtKB=P05987	cAMP-dependent protein kinase regulatory subunit	IC	92186968	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00049	Parkinson disease	P01242	Casein kinase I	RAT|RGD=71031|UniProtKB=Q06486	Casein kinase I isoform delta	IDA	11437445	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	DANRE|ZFIN=ZDB-GENE-020503-1|UniProtKB=Q1LWJ4	Tyrosine-protein kinase receptor	ISS	249616	gi	PTHR24416:SF498	TYROSINE-PROTEIN KINASE RECEPTOR
P00021	FGF signaling pathway	P00642	MEK1-2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	94313981	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02738	De novo purine biosynthesis	P02909	GDP reductase	MONDO|Ensembl=ENSMODG00000005993|UniProtKB=F6SL91	Uncharacterized protein	ISS			PTHR23409:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 B
P00053	T cell activation	P01333	cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TRIVA|Gene=TVAG_054030|UniProtKB=A2G1K5	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00575	furin	BOVIN|Gene=FURIN|UniProtKB=Q28193	Furin	ISS	95328031	PubMed	PTHR42884:SF1	FURIN
P00005	Angiogenesis	P00249	PAK	CHICK|Ensembl=ENSGALG00000000681|UniProtKB=E1C3P6	Uncharacterized protein	ISS	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01457	GBeta	RAT|RGD=69319|UniProtKB=P54313	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IDA	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00046	Oxidative stress response	P01131	MKP5	RAT|RGD=1307457|UniProtKB=D4A8F3	Dual specificity phosphatase 19 (Predicted), isoform CRA_b	ISS			PTHR10159:SF402	DUAL SPECIFICITY PROTEIN PHOSPHATASE 19
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	TAS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	2837282	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00057	Wnt signaling pathway	P01454	betaTrCP	HUMAN|HGNC=13607|UniProtKB=Q9UKB1	F-box/WD repeat-containing protein 11	IDA	10074433	PubMed	PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P04393	Ras Pathway	P04543	MEKK1/4	HUMAN|HGNC=6856|UniProtKB=Q9Y6R4	Mitogen-activated protein kinase kinase kinase 4	IDA	602425	OMIM	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	MOUSE|MGI=MGI=99666|UniProtKB=P46097	Synaptotagmin-2	RCA	SYT2_MOUSE	SPACC	PTHR10024:SF223	SYNAPTOTAGMIN-2
P00060	Ubiquitin proteasome pathway	P01491	E2	XENTR|Xenbase=XB-GENE-954055|UniProtKB=Q28I82	Ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast)	ISS			PTHR24067:SF154	UBIQUITIN-CONJUGATING ENZYME E2 G2
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04376	5HT4 type receptor mediated signaling pathway	P04426	K+ channel	BOVIN|Ensembl=ENSBTAG00000047488|UniProtKB=G3N1D1	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00019	Endothelin signaling pathway	P00591	PLCbeta	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00582	COX-2	MOUSE|MGI=MGI=97798|UniProtKB=Q05769	Prostaglandin G/H synthase 2	IPI	12163371	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	YEAST|SGD=S000005738|UniProtKB=P18851	Guanine nucleotide-binding protein subunit beta	IC	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00059	p53 pathway	G04694	p110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00011	Blood coagulation	P00417	TFPI	CANLF|Ensembl=ENSCAFG00000014752|UniProtKB=Q28874	Tissue factor pathway inhibitor	ISS	1083171	gi	PTHR10083:SF317	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00046	Oxidative stress response	P01126	ATF2	PANTR|Ensembl=ENSPTRG00000012660|UniProtKB=H2QJ07	Activating transcription factor 2	ISS	10207617	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P06959	CCKR signaling map	P07114	JUN	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	RCA	12239223	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P05912	Dopamine receptor mediated signaling pathway	P05957	K+ channel	MOUSE|MGI=MGI=3521816|UniProtKB=Q3LS21	Potassium channel subfamily K member 9	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DROME|FlyBase=FBgn0000489|UniProtKB=P16912	Protein kinase DC2	IC	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04397	p53 pathway by glucose deprivation	P04641	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=15983|UniProtKB=P56704	Protein Wnt-3a	IDA	8717036	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00014	Cholesterol biosynthesis	P00498	Hydroxymethyl glutaryl CoA synthase	MACMU|Ensembl=ENSMMUG00000001226|UniProtKB=F7HQ90	Hydroxymethylglutaryl-CoA synthase, cytoplasmic	ISS	600234	OMIM	PTHR43323:SF4	HYDROXYMETHYLGLUTARYL-COA SYNTHASE, CYTOPLASMIC
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	CAEEL|WormBase=WBGene00003472|UniProtKB=Q960A2	MTK1/MEKK4 homolog	ISS			PTHR24361:SF642	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01411	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95814|UniProtKB=Q60934	Glutamate receptor ionotropic, kainate 1	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	PANTR|Ensembl=ENSPTRG00000017291|UniProtKB=H2QRK9	Catenin (Cadherin-associated protein), alpha 1, 102kDa	ISS	1768802	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00633	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P00048	PI3 kinase pathway	P01185	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00022	General transcription by RNA polymerase I	P00657	TBP	CAEEL|WormBase=WBGene00006542|UniProtKB=P32085	TATA-box-binding protein	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8660|UniProtKB=O95206	Protocadherin-8	IDA	8120095	PubMed	PTHR24028:SF46	PROTOCADHERIN-8
P00005	Angiogenesis	P00181	SHP2	CHICK|Ensembl=ENSGALG00000004821|UniProtKB=Q90687	Tyrosine-protein phosphatase non-receptor type 11	ISS	14534538	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00640	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	MONDO|Ensembl=ENSMODG00000011192|UniProtKB=F6SRK5	Uncharacterized protein	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00948	Rho	XENTR|Xenbase=XB-GENE-941426|UniProtKB=Q28HZ4	Novel Rho protein	ISS	15668138	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00047	PDGF signaling pathway	P01171	PLCgamma	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00018	EGF receptor signaling pathway	P00561	STAT	HUMAN|HGNC=11368|UniProtKB=P42226	Signal transducer and activator of transcription 6	IGI	8085155	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	SCHMA|EnsemblGenome=Smp_183710|UniProtKB=G4VLW1	Putative actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CHICK|Ensembl=ENSGALG00000006638|UniProtKB=R4GGL9	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00052	TGF-beta signaling pathway	P01284	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P02736	Coenzyme A biosynthesis	P02884	Dephospho-CoA kinase	AQUAE|EnsemblGenome=aq_1985|UniProtKB=O67792	Dephospho-CoA kinase	ISS			PTHR10695:SF26	BIFUNCTIONAL COENZYME A SYNTHASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00047	PDGF signaling pathway	P01164	PDK1/2	CAEEL|WormBase=WBGene00003965|UniProtKB=Q9Y1J3	3-phosphoinositide-dependent protein kinase 1	ISS	10364160	PubMed	PTHR24356:SF309	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DICPU|Gene=DICPUDRAFT_98135|UniProtKB=F0ZMZ8	Putative uncharacterized protein racE	ISS			PTHR24072:SF143	RHO-RELATED PROTEIN RACE
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01067	AChE	CAEEL|WormBase=WBGene00000035|UniProtKB=P38433	Acetylcholinesterase 1	IC			PTHR43918:SF3	ACETYLCHOLINESTERASE
P05915	Opioid proenkephalin pathway	P05990	K+ channel	BOVIN|Ensembl=ENSBTAG00000047488|UniProtKB=G3N1D1	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00054	Toll receptor signaling pathway	P01355	AP1	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00003	Alzheimer disease-amyloid secretase pathway	P00090	MDC9	MACMU|Ensembl=ENSMMUG00000006033|UniProtKB=F6WJ32	Uncharacterized protein	ISS	10510302	PubMed	PTHR11905:SF136	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 9
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04384	Gamma-aminobutyric acid synthesis	P04482	Glutamate decarboxylase	MACMU|Ensembl=ENSMMUG00000010033|UniProtKB=F6Q185	Uncharacterized protein	ISS			PTHR11999:SF95	ACIDIC AMINO ACID DECARBOXYLASE GADL1
P00018	EGF receptor signaling pathway	P00565	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01326	CD3 delta	MOUSE|MGI=MGI=88331|UniProtKB=P04235	T-cell surface glycoprotein CD3 delta chain	IPI	9348303	PubMed	PTHR10570:SF5	T-CELL SURFACE GLYCOPROTEIN CD3 DELTA CHAIN
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	ARATH|TAIR=AT1G55970|UniProtKB=Q9LG11	Histone acetyltransferase HAC4	TAS	10769018	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00047	PDGF signaling pathway	P01154	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IGI	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	MONDO|Ensembl=ENSMODG00000013667|UniProtKB=F6TXD9	Adenylosuccinate synthetase isozyme 1	ISS	10636885	PubMed	PTHR11846:SF2	ADENYLOSUCCINATE SYNTHETASE ISOZYME 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00048	PI3 kinase pathway	P01189	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	ORYSJ|EnsemblGenome=OS06G0699400|UniProtKB=Q5Z859	Mitogen-activated protein kinase 4	ISS			PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00056	VEGF signaling pathway	P01411	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P02749	Leucine biosynthesis	P03001	3-Isopropylmalate dehydrogenase	CANAL|CGD=CAL0002168|UniProtKB=Q5AFI8	3-isopropylmalate dehydrogenase	ISS			PTHR42979:SF1	3-ISOPROPYLMALATE DEHYDROGENASE
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00037	Ionotropic glutamate receptor pathway	P01026	KA	HUMAN|HGNC=4583|UniProtKB=Q16478	Glutamate receptor ionotropic, kainate 5	ISS	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	HUMAN|HGNC=1460|UniProtKB=Q9UQM7	Calcium/calmodulin-dependent protein kinase type II subunit alpha	ISS	12888804	PubMed	PTHR43940:SF5	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00029	Huntington disease	P00810	GAPDH	TAKRU|Ensembl=ENSTRUG00000003708|UniProtKB=H2S8H3	Glyceraldehyde-3-phosphate dehydrogenase	ISS	8612237	PubMed	PTHR10836:SF51	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE
P00034	Integrin signalling pathway	P00944	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g242065|UniProtKB=A7S0V7	Predicted protein	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	RAT|RGD=2917|UniProtKB=P15127	Insulin receptor	ISS	249616	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00023	General transcription regulation	P00670	TBP	BOVIN|Ensembl=ENSBTAG00000035370|UniProtKB=Q32LB1	TATA box-binding protein-like protein 1	ISS	10082669	PubMed	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	ARATH|TAIR=AT4G36450|UniProtKB=O23236	Mitogen-activated protein kinase 14	TAS			PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00019	Endothelin signaling pathway	P00591	PLCbeta	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00005	Angiogenesis	P00181	SHP2	MONDO|Ensembl=ENSMODG00000003120|UniProtKB=F6WVD2	Tyrosine-protein phosphatase non-receptor type	ISS	7681589	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P04398	p53 pathway feedback loops 2	P04649	Myc	MOUSE|MGI=MGI=97250|UniProtKB=P01108	Myc proto-oncogene protein	TAS	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	IC	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	HUMAN|HGNC=16844|UniProtKB=Q02930	Cyclic AMP-responsive element-binding protein 5	RCA			PTHR19304:SF8	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 5
P00021	FGF signaling pathway	P00624	14-3-3	ORYSJ|EnsemblGenome=OS02G0580300|UniProtKB=Q6EUP4	14-3-3-like protein GF14-E	ISS	10407019	PubMed	PTHR18860:SF36	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00640	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00968	Ikk	BOVIN|Ensembl=ENSBTAG00000007599|UniProtKB=Q95KV0	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IDA	98189216	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00021	FGF signaling pathway	P00646	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	227170	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	IC	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	RAT|RGD=69430|UniProtKB=P32851	Syntaxin-1A	TAS	1321498	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	ORNAN|Ensembl=ENSOANG00000011267|UniProtKB=F7DPD5	Uncharacterized protein	ISS	11679592	PubMed	PTHR23122:SF40	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P00060	Ubiquitin proteasome pathway	P01491	E2	PANTR|Ensembl=ENSPTRG00000005297|UniProtKB=H2Q6L8	Ubiquitin-conjugating enzyme E2N	ISS			PTHR43902:SF5	UBIQUITIN-CONJUGATING ENZYME E2 N
P00048	PI3 kinase pathway	P01177	P110ACT	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00238	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	ORYSJ|EnsemblGenome=OS05G0413200|UniProtKB=Q76FS3	Tubulin beta-6 chain	ISS	12932731	PubMed	PTHR11588:SF249	SUBFAMILY NOT NAMED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00056	VEGF signaling pathway	P01408	Akt/PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00187	beta catenin	PANTR|Ensembl=ENSPTRG00000023062|UniProtKB=H2R2U1	Catenin (Cadherin-associated protein), beta 1, 88kDa	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P00025	Hedgehog signaling pathway	P00682	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00025	Hedgehog signaling pathway	P00685	Smoothened	RAT|RGD=3726|UniProtKB=P97698	Smoothened homolog	ISS	10021362	PubMed	PTHR11309:SF35	SMOOTHENED HOMOLOG
P00010	B cell activation	P00376	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00054	Toll receptor signaling pathway	P01358	ERK1	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CAEEL|WormBase=WBGene00000063|UniProtKB=P0DM41	Actin-1	IC	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	TAS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00049	Parkinson disease	P01208	Hsp70	CAEEL|WormBase=WBGene00002007|UniProtKB=P27420	Heat shock 70 kDa protein C	IDA	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00057	Wnt signaling pathway	P01435	SWI/SNF	PANTR|Ensembl=ENSPTRG00000016472|UniProtKB=H2QQ80	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5	ISS	11532957	PubMed	PTHR10799:SF887	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00019	Endothelin signaling pathway	P00575	furin	MACMU|Ensembl=ENSMMUG00000004657|UniProtKB=G7MVY8	Furin	ISS	95328031	PubMed	PTHR42884:SF1	FURIN
P00053	T cell activation	P01312	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02723	Adenine and hypoxanthine salvage pathway	P02811	Adenosine deaminase	ECOLI|EcoGene=EG10030|UniProtKB=P22333	Adenosine deaminase	ISS			PTHR11409:SF43	ADENOSINE DEAMINASE
P02738	De novo purine biosynthesis	P02900	AICAR transformylase	RAT|RGD=70879|UniProtKB=O35567	Bifunctional purine biosynthesis protein PURH	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05925	beta-ARR1	PANTR|Ensembl=ENSPTRG00000004079|UniProtKB=H2R1Z2	Uncharacterized protein	ISS	4757780	gi	PTHR11792:SF22	BETA-ARRESTIN-1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	RCA	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04397	p53 pathway by glucose deprivation	P04641	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00211	GSK3beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00011	Blood coagulation	P00461	PAR-4	MOUSE|MGI=MGI=1298207|UniProtKB=O88634	Proteinase-activated receptor 4	ISS	20138808	gi	PTHR24232:SF22	PROTEINASE-ACTIVATED RECEPTOR 4
P00057	Wnt signaling pathway	P01428	Frizzled	HUMAN|HGNC=4041|UniProtKB=Q9NPG1	Frizzled-3	IDA	11212302	PubMed	PTHR11309:SF22	FRIZZLED-3
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P05912	Dopamine receptor mediated signaling pathway	P05962	DAT	RAT|RGD=3715|UniProtKB=P23977	Sodium-dependent dopamine transporter	ISS	15135042	PubMed	PTHR11616:SF38	SODIUM-DEPENDENT DOPAMINE TRANSPORTER
P00025	Hedgehog signaling pathway	P00683	Slimb	CHICK|Ensembl=ENSGALG00000007820|UniProtKB=F1NYG1	Uncharacterized protein	ISS	10074433	PubMed	PTHR44038:SF2	F-BOX/WD REPEAT-CONTAINING PROTEIN 1A
P00056	VEGF signaling pathway	P01408	Akt/PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00006	Apoptosis signaling pathway	P00274	JNK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	ISS	7600581	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00018	EGF receptor signaling pathway	P00560	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000023202|UniProtKB=F7EU36	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	SCHMA|EnsemblGenome=Smp_202970|UniProtKB=G4VLN1	Putative uncharacterized protein Smp_202970	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00777	CBP	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00030	Hypoxia response via HIF activation	P00823	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00589	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IGI	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00049	Parkinson disease	P01211	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01227	20S proteasome	ARATH|TAIR=AT5G66140|UniProtKB=O24616	Proteasome subunit alpha type-7-B	ISS	12859888	PubMed	PTHR11599:SF15	PROTEASOME SUBUNIT ALPHA TYPE
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00005	Angiogenesis	P00189	Fzd	MONDO|Ensembl=ENSMODG00000008701|UniProtKB=F6PWM3	Uncharacterized protein	ISS	12549854	PubMed	PTHR11309:SF22	FRIZZLED-3
P06209	ALP23B signaling pathway	P06227	FUR1	DROME|FlyBase=FBgn0004509|UniProtKB=P26016	Furin-like protease 1, isoforms 1/1-X/2	IEA	10956649	PubMed	PTHR42884:SF3	FURIN-LIKE PROTEASE 1, ISOFORMS 1/1-X/2
P00056	VEGF signaling pathway	P01413	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	129387	gi	PTHR10048:SF14	PI-3 KINASE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	DROME|FlyBase=FBgn0039914|UniProtKB=Q9V4E6	Maverick	ISS			PTHR11848:SF169	ANTI-DORSALIZING MORPHOGENETIC PROTEIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TRIVA|Gene=TVAG_090470|UniProtKB=A2FA04	Actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	ARATH|TAIR=AT1G16710|UniProtKB=Q9FWQ5	Histone acetyltransferase HAC12	IDA			PTHR13808:SF1	NEJIRE, ISOFORM C
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05918	p38 MAPK pathway	P06034	MKK4	HUMAN|HGNC=6844|UniProtKB=P45985	Dual specificity mitogen-activated protein kinase kinase 4	IDA	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00056	VEGF signaling pathway	P01415	MAPKAPK2/3	RAT|RGD=1304980|UniProtKB=Q66H84	MAP kinase-activated protein kinase 3	ISS	11157753	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P05913	Enkephalin release	P05972	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00010	B cell activation	P00391	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01437	TCF	HUMAN|HGNC=11640|UniProtKB=Q9HCS4	Transcription factor 7-like 1	IDA	12356903	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00018	EGF receptor signaling pathway	P00564	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	20010089	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00010	B cell activation	P00369	MEKK	BOVIN|Ensembl=ENSBTAG00000004216|UniProtKB=F1MSX4	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	IC	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00021	FGF signaling pathway	P00624	14-3-3	HUMAN|HGNC=12854|UniProtKB=P27348	14-3-3 protein theta	IPI	10407019	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01177	P110ACT	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IGI	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	HUMAN|HGNC=5964|UniProtKB=Q13651	Interleukin-10 receptor subunit alpha	IC	8407942	PubMed	PTHR20859:SF43	INTERLEUKIN-10 RECEPTOR SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PHYPA|Gene=PHYPADRAFT_225906|UniProtKB=A9TVP1	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P06959	CCKR signaling map	P07164	CCK-58	HUMAN|HGNC=1569|UniProtKB=P06307	Cholecystokinin	RCA		PubMed	PTHR10786:SF0	CHOLECYSTOKININ
P02741	Flavin biosynthesis	P02939	Lumazine synthase	SCHPO|PomBase=SPBC409.13|UniProtKB=Q9UUB1	6,7-dimethyl-8-ribityllumazine synthase	ISS			PTHR21058:SF0	6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE
P00038	JAK/STAT signaling pathway	P01033	PTP	PANTR|Ensembl=ENSPTRG00000001817|UniProtKB=H2Q0U9	Uncharacterized protein	ISS	1672451	PubMed	PTHR19134:SF284	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	MOUSE|MGI=MGI=97364|UniProtKB=O35516	Neurogenic locus notch homolog protein 2	IDA	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00053	T cell activation	P01300	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00223	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=12789|UniProtKB=Q93098	Protein Wnt-8b	TAS	8717036	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00019	Endothelin signaling pathway	P00591	PLCbeta	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00021	FGF signaling pathway	P00640	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00645	Rac	ENTHI|EnsemblGenome=EHI_070730|UniProtKB=C4M5T0	Rho family GTPase	ISS	12932731	PubMed	PTHR24072:SF117	RHO-RELATED PROTEIN RACC
P00053	T cell activation	P01306	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00054	Toll receptor signaling pathway	P01356	ERK2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00558	SOS	DICDI|dictyBase=DDB_G0269222|UniProtKB=Q8IS21	Ras guanine nucleotide exchange factor B	IGI			PTHR23113:SF163	RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MACMU|Ensembl=ENSMMUG00000010184|UniProtKB=F6SR09	Uncharacterized protein	ISS	8314195	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00047	PDGF signaling pathway	P01151	PKB	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00585	ECE1-3	MACMU|Ensembl=ENSMMUG00000010942|UniProtKB=F7GIX6	Uncharacterized protein	ISS	96192242	PubMed	PTHR11733:SF130	ENDOTHELIN-CONVERTING ENZYME 1
P00010	B cell activation	P00371	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00047	PDGF signaling pathway	P01167	Ets	MONDO|Ensembl=ENSMODG00000015354|UniProtKB=F6WXL8	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF203	PROTEIN FEV
P00010	B cell activation	P00402	Jnk	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00025	Hedgehog signaling pathway	P00682	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00981	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	IDA	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00029	Huntington disease	P00790	beta-Tubulin	ARATH|TAIR=AT5G23860|UniProtKB=P29516	Tubulin beta-8 chain	TAS	9454836	PubMed	PTHR11588:SF264	TUBULIN BETA-8 CHAIN
P00018	EGF receptor signaling pathway	P00547	PP2A	HUMAN|HGNC=9311|UniProtKB=Q13362	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	ISS	10092233	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	NAS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00012	Cadherin signaling pathway	P00474	Wnt	RAT|RGD=1597195|UniProtKB=D4A9J2	Protein Wnt	ISS	14644163	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00021	FGF signaling pathway	P00633	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00021	FGF signaling pathway	P00642	MEK1-2	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IGI	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05913	Enkephalin release	P05971	CREB	MOUSE|MGI=MGI=88495|UniProtKB=P27699	cAMP-responsive element modulator	ISS			PTHR22952:SF97	CAMP-RESPONSIVE ELEMENT MODULATOR
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000019277|UniProtKB=H2QUQ1	Uncharacterized protein	ISS	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00059	p53 pathway	G01579	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00005	Angiogenesis	P00223	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00203	Erk	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00552	Ras	TAKRU|Ensembl=ENSTRUG00000005329|UniProtKB=H2SK54	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P02734	Chorismate biosynthesis	P02869	3-Dehydroquinate dehydratase	FUSNN|EnsemblGenome=FN0046|UniProtKB=Q8RH64	3-dehydroquinate dehydratase	ISS			PTHR21272:SF3	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	TAS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04392	P53 pathway feedback loops 1	P04539	p53	DANRE|ZFIN=ZDB-GENE-030814-2|UniProtKB=B0S576	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	IC	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00251	cPLA2	PANTR|Ensembl=ENSPTRG00000001787|UniProtKB=H2Q0T0	Phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	SCHPO|PomBase=SPAC6G9.11|UniProtKB=Q92356	Synaptobrevin homolog 1	ISS			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-478663|UniProtKB=F7EG64	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00005	Angiogenesis	P00206	Wnt	MACMU|Ensembl=ENSMMUG00000015705|UniProtKB=F6SM00	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=11330|UniProtKB=P30872	Somatostatin receptor type 1	IDA	12562507	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	MOUSE|MGI=MGI=95818|UniProtKB=Q61626	Glutamate receptor ionotropic, kainate 5	ISS	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00018	EGF receptor signaling pathway	P00546	GAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00005	Angiogenesis	P00219	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00006	Apoptosis signaling pathway	P00313	IKK	HUMAN|HGNC=5960|UniProtKB=O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	PANTR|Ensembl=ENSPTRG00000006510|UniProtKB=H2Q8K1	Presenilin	ISS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00045	Notch signaling pathway	P01101	Su(H)	MOUSE|MGI=MGI=96522|UniProtKB=P31266	Recombining binding protein suppressor of hairless	IDA	12145413	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00036	Interleukin signaling pathway	P00973	PKB	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	9094314	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=96273|UniProtKB=Q64264	5-hydroxytryptamine receptor 1A	IDA	12181435	PubMed	PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00006	Apoptosis signaling pathway	P00278	Bag	PANTR|Ensembl=ENSPTRG00000002998|UniProtKB=H2Q2N9	BCL2-associated athanogene 3	ISS			PTHR12329:SF12	BAG FAMILY MOLECULAR CHAPERONE REGULATOR 3
P00057	Wnt signaling pathway	P01435	SWI/SNF	BOVIN|Gene=CHD1L|UniProtKB=Q3B7N1	Chromodomain-helicase-DNA-binding protein 1-like	ISS	11532957	PubMed	PTHR10799:SF949	CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1-LIKE
P04395	Vasopressin synthesis	P04593	Glycopeptide	TAKRU|Ensembl=ENSTRUG00000015631|UniProtKB=H2USP0	Uncharacterized protein	IC			PTHR11681:SF14	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01185	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00017	DNA replication	P00527	Histones	STRPU|EnsemblGenome=SPU_000307|UniProtKB=W4XAB3	Histone H3	ISS	12413958	PubMed	PTHR11426:SF20	HISTONE H3-LIKE CENTROMERIC PROTEIN A
P00056	VEGF signaling pathway	P01415	MAPKAPK2/3	BOVIN|Ensembl=ENSBTAG00000038107|UniProtKB=F1MCX5	Uncharacterized protein	ISS	10779545	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8716|UniProtKB=Q9UN70	Protocadherin gamma-C3	IDA	8120095	PubMed	PTHR24028:SF70	PROTOCADHERIN GAMMA-C3
P00053	T cell activation	P01300	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CAEBR|Gene=CBG05858|UniProtKB=A8X1H0	Protein CBR-EGL-19 (Fragment)	ISS	9199552	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00021	FGF signaling pathway	P00640	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00054	Toll receptor signaling pathway	P01375	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CAEEL|WormBase=WBGene00006537|UniProtKB=P52275	Tubulin beta-2 chain	ISS	12932731	PubMed	PTHR11588:SF84	TUBULIN BETA-2 CHAIN
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MACMU|Ensembl=ENSMMUG00000010392|UniProtKB=F7ASR8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MACMU|Ensembl=ENSMMUG00000009341|UniProtKB=F6UA54	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P02781	Threonine biosynthesis	P03191	Homoserine kinase	BACSU|EnsemblGenome=BSU32240|UniProtKB=P04948	Homoserine kinase	ISS			PTHR20861:SF1	HOMOSERINE KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00056	VEGF signaling pathway	P01408	Akt/PKB	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	90172230	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=1922542|UniProtKB=Q8K1Y2	Serine/threonine-protein kinase D3	ISS	12676944	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IGI	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00034	Integrin signalling pathway	P00939	Fibronectin	XENTR|Xenbase=XB-GENE-484447|UniProtKB=F7EAN4	Uncharacterized protein	ISS	12970173	PubMed	PTHR19143:SF267	FIBRONECTIN
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00011	Blood coagulation	P00444	FIX	MACMU|Ensembl=ENSMMUG00000020064|UniProtKB=F7GHR4	Uncharacterized protein	ISS	182609	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	MACMU|Ensembl=ENSMMUG00000014666|UniProtKB=F7FLW2	Pyrroline-5-carboxylate reductase	ISS			PTHR11645:SF22	PYRROLINE-5-CARBOXYLATE REDUCTASE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00046	Oxidative stress response	P01138	MKK4	HUMAN|HGNC=6844|UniProtKB=P45985	Dual specificity mitogen-activated protein kinase kinase 4	TAS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DANRE|ZFIN=ZDB-GENE-040625-35|UniProtKB=Q6IQL9	Novel actin protein	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00049	Parkinson disease	P01212	p38 MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	NAS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01465	Ggamma	CANLF|Ensembl=ENSCAFG00000028654|UniProtKB=J9P702	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00059	p53 pathway	P04633	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00379	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	ANOGA|EnsemblGenome=AGAP010750|UniProtKB=Q7PMK5	AGAP010750-PA	ISS	8930069	PubMed	PTHR13715:SF79	RYANODINE RECEPTOR
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04398	p53 pathway feedback loops 2	P04661	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	G01511	SPRY	HUMAN|HGNC=11270|UniProtKB=O43597	Protein sprouty homolog 2	IGI	12815057	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P00029	Huntington disease	P00805	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00046	Oxidative stress response	P01121	MKK3/6	BOVIN|Ensembl=ENSBTAG00000010576|UniProtKB=A4IFH7	MAP2K3 protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00007	Axon guidance mediated by semaphorins	P00329	Sema4D	PANTR|Ensembl=ENSPTRG00000022584|UniProtKB=H2R6L6	Uncharacterized protein	ISS			PTHR11036:SF18	SEMAPHORIN-4D
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	DROME|FlyBase=FBgn0019947|UniProtKB=O02194	Presenilin homolog	TAS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00029	Huntington disease	G01530	HTT	MOUSE|MGI=MGI=96067|UniProtKB=P42859	Huntingtin	IDA	9462744	PubMed	PTHR10170:SF10	HUNTINGTIN
P06959	CCKR signaling map	P07055	SNAI1	HUMAN|HGNC=11128|UniProtKB=O95863	Zinc finger protein SNAI1	RCA	15833848	PubMed	PTHR44037:SF4	ZINC FINGER PROTEIN SNAI1
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CHICK|Ensembl=ENSGALG00000002536|UniProtKB=Q5ZMT6	Uncharacterized protein	ISS			PTHR19957:SF36	SYNTAXIN-2
P04398	p53 pathway feedback loops 2	G04714	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MONDO|Ensembl=ENSMODG00000019262|UniProtKB=F6Q8L1	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00056	VEGF signaling pathway	P01407	Erk	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02783	Tryptophan biosynthesis	P03208	Tryptophan synthase B	FUSNN|EnsemblGenome=FN0317|UniProtKB=Q8RGH8	Tryptophan synthase beta chain	ISS			PTHR42882:SF1	TRYPTOPHAN SYNTHASE
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MOUSE|MGI=MGI=96273|UniProtKB=Q64264	5-hydroxytryptamine receptor 1A	ISS	2156831	PubMed	PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P00010	B cell activation	P00384	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00589	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P06959	CCKR signaling map	P07194	MAP2K1	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	RCA	16816139	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05913	Enkephalin release	P05974	G-Protein (i)	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	IC	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00049	Parkinson disease	P01227	20S proteasome	DROME|FlyBase=FBgn0023175|UniProtKB=Q9V5C6	Proteasome subunit alpha type-3	TAS	12859888	PubMed	PTHR11599:SF10	PROTEASOME SUBUNIT ALPHA TYPE-3
P05916	Opioid prodynorphin pathway	P06002	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	9395335	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	P01448	CBP	CAEEL|WormBase=WBGene00000366|UniProtKB=P34545	Protein cbp-1	ISS	10664585	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	DANRE|ZFIN=ZDB-GENE-020125-5|UniProtKB=A2CG69	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF356	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00008	Axon guidance mediated by Slit/Robo	P00342	Slit	HUMAN|HGNC=11085|UniProtKB=O75093	Slit homolog 1 protein	ISS	10102268	PubMed	PTHR24373:SF39	SLIT HOMOLOG 1 PROTEIN
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	HUMAN|HGNC=4583|UniProtKB=Q16478	Glutamate receptor ionotropic, kainate 5	ISS	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00012	Cadherin signaling pathway	P00467	alpha-catenin	CHICK|Ensembl=ENSGALG00000002447|UniProtKB=E1C7M7	Uncharacterized protein	ISS	9362521	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	10395542	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00633	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=97614|UniProtKB=Q8R3B1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	12860966	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	RAT|RGD=1304749|UniProtKB=A0A0G2K0H3	Protein Lrp6	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00053	T cell activation	P01332	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00470	F-actin	PRIPA|Gene=PPA23459|UniProtKB=H3FMF2	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	RAT|RGD=628837|UniProtKB=P60711	Actin, cytoplasmic 1	IC	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00015	Circadian clock system	G01497	cry	ORNAN|Ensembl=ENSOANG00000005350|UniProtKB=F6X852	Uncharacterized protein	ISS	11533252	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	BOVIN|Ensembl=ENSBTAG00000033153|UniProtKB=F1MG21	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00049	Parkinson disease	P01227	20S proteasome	TRYB2|Gene=Tb10.100.0120|UniProtKB=Q38CL5	Proteasome subunit alpha type	TAS	12859888	PubMed	PTHR11599:SF14	PROTEASOME SUBUNIT ALPHA TYPE-5
P00036	Interleukin signaling pathway	P00996	STAT	MONDO|Ensembl=ENSMODG00000028212|UniProtKB=F7BYN4	Signal transducer and activator of transcription	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05912	Dopamine receptor mediated signaling pathway	P05960	VAT2	PANTR|Ensembl=ENSPTRG00000002979|UniProtKB=H2Q2M8	Uncharacterized protein	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P06959	CCKR signaling map	P07199	GSK3beta	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	RCA	18515095	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00052	TGF-beta signaling pathway	P01292	RSmads	CHICK|Ensembl=ENSGALG00000009977|UniProtKB=Q56IA0	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04551	RalGDS	MACMU|Ensembl=ENSMMUG00000003872|UniProtKB=F7H7Z5	Ral guanine nucleotide dissociation stimulator-like 2	ISS	8939933	PubMed	PTHR23113:SF213	RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 2
P00047	PDGF signaling pathway	P01162	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00030	Hypoxia response via HIF activation	P00819	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02775	Salvage pyrimidine ribonucleotides	P03156	CDP kinase	HUMAN|HGNC=7852|UniProtKB=O00746	Nucleoside diphosphate kinase, mitochondrial	ISS			PTHR11349:SF49	NUCLEOSIDE DIPHOSPHATE KINASE, MITOCHONDRIAL
P00018	EGF receptor signaling pathway	P00539	14-3-3	PANTR|Ensembl=ENSPTRG00000013529|UniProtKB=H2R8X6	Uncharacterized protein	ISS	91108808	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00006	Apoptosis signaling pathway	P00260	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	NEUCR|EnsemblGenome=EFNCRG00000002538|UniProtKB=Q1K522	Aldehyde dehydrogenase	IC			PTHR11699:SF266	SUBFAMILY NOT NAMED
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	CANLF|Ensembl=ENSCAFG00000004090|UniProtKB=F1PNQ0	Uncharacterized protein	ISS	12623444	PubMed	PTHR11920:SF291	ADENYLATE CYCLASE TYPE 3
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	RAT|RGD=1307863|UniProtKB=D3ZXI0	Pyrroline-5-carboxylate reductase	ISS			PTHR11645:SF6	PYRROLINE-5-CARBOXYLATE REDUCTASE 1, MITOCHONDRIAL
P00047	PDGF signaling pathway	P01154	Ras	BOVIN|Ensembl=ENSBTAG00000002174|UniProtKB=Q0VCJ7	Ras-related and estrogen-regulated growth inhibitor	ISS			PTHR24070:SF373	RAS-RELATED AND ESTROGEN-REGULATED GROWTH INHIBITOR
P05916	Opioid prodynorphin pathway	P05999	provasopressin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	ISS	11035810	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000014173|UniProtKB=H2QLD7	Adenosine receptor A2	ISS			PTHR24246:SF27	ADENOSINE RECEPTOR A2A
P00035	Interferon-gamma signaling pathway	P00958	PIAS	RAT|RGD=1307843|UniProtKB=G3V9T0	Protein Pias1	ISS	8682149	PubMed	PTHR10782:SF11	E3 SUMO-PROTEIN LIGASE PIAS1
P00034	Integrin signalling pathway	P00907	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00265	Granzyme B	RAT|RGD=620018|UniProtKB=P18291	Granzyme B	ISS			PTHR24271:SF41	GRANZYME B
P00053	T cell activation	P01300	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00796	Kainate receptor	PANTR|Ensembl=ENSPTRG00000011042|UniProtKB=H2QGF5	Uncharacterized protein	ISS	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MOUSE|MGI=MGI=104589|UniProtKB=P63268	Actin, gamma-enteric smooth muscle	IC	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	ORNAN|Ensembl=ENSOANG00000013097|UniProtKB=F6UVN1	Uncharacterized protein	ISS	10082669	PubMed	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	IDA	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IC	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02753	Methionine biosynthesis	P03024	Homocysteine transmethylase	ARATH|TAIR=AT3G22740|UniProtKB=Q8LAX0	Homocysteine S-methyltransferase 3	ISS			PTHR21091:SF159	HOMOCYSTEINE S-METHYLTRANSFERASE 3
P05918	p38 MAPK pathway	P06015	p38gamma	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	RCA	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12874273	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	188830	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	PANTR|Ensembl=ENSPTRG00000011718|UniProtKB=H2QHJ5	Adenylate cyclase 3	ISS	2491850	PubMed	PTHR11920:SF291	ADENYLATE CYCLASE TYPE 3
P00047	PDGF signaling pathway	P01153	GSK3	NEUCR|EnsemblGenome=EFNCRG00000003957|UniProtKB=V5ILY7	Protein kinase gsk3	ISS	12615961	PubMed	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	IDA	15737619	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CAEEL|WormBase=WBGene00006454|UniProtKB=G5EEN8	AEX-4	IC			PTHR19305:SF10	AEX-4
P00034	Integrin signalling pathway	P00947	Laminin	DROME|FlyBase=FBgn0261563|UniProtKB=Q8IP51	Wing blister, isoform B	IPI	2538453	PubMed	PTHR10574:SF359	LAMININ SUBUNIT ALPHA-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DANRE|ZFIN=ZDB-GENE-000322-1|UniProtKB=Q9I8V1	Actin, alpha 1, skeletal muscle	IC	14684598	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	ISS	12855688	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P06212	DPP-SCW signaling pathway	P06272	DPP	DROME|FlyBase=FBgn0000490|UniProtKB=P07713	Protein decapentaplegic	IEA	http://flybase.org/reports/FBgn0000490.html	Website	PTHR11848:SF234	PROTEIN DECAPENTAPLEGIC
P00047	PDGF signaling pathway	P01167	Ets	MONDO|Ensembl=ENSMODG00000004730|UniProtKB=F6Y1Z2	Uncharacterized protein	ISS	9157999	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	HUMAN|HGNC=4594|UniProtKB=Q14416	Metabotropic glutamate receptor 2	ISS	20012997	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	11251832	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00047	PDGF signaling pathway	P01174	Rho	RAT|RGD=1308507|UniProtKB=A0A0G2K7N9	Protein Arhgap5	ISS			PTHR15377:SF4	RHO GTPASE-ACTIVATING PROTEIN 5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	BOVIN|Ensembl=ENSBTAG00000013657|UniProtKB=Q8SPU7	Neuronal acetylcholine receptor subunit alpha-5	ISS	85270494	PubMed	PTHR18945:SF76	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00019	Endothelin signaling pathway	P00583	cPLA2	RAT|RGD=67366|UniProtKB=P50393	Cytosolic phospholipase A2	IGI	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00554	Shc	MACMU|Ensembl=ENSMMUG00000020357|UniProtKB=F6W915	SHC-transforming protein 3	ISS	96404502	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P00048	PI3 kinase pathway	P01181	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00635	FRS2	HUMAN|HGNC=16971|UniProtKB=Q8WU20	Fibroblast growth factor receptor substrate 2	IGI	10464310	PubMed	PTHR21258:SF40	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00056	VEGF signaling pathway	P01407	Erk	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00048	PI3 kinase pathway	P01177	P110ACT	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	CHICK|Ensembl=ENSGALG00000001334|UniProtKB=F1NLV4	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00030	Hypoxia response via HIF activation	P00819	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	BOVIN|Ensembl=ENSBTAG00000043994|UniProtKB=E1BP29	Protein-serine/threonine kinase	RCA			PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	DICPU|Gene=DICPUDRAFT_91367|UniProtKB=F0ZB76	Putative uncharacterized protein rasD	ISS	85024887	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00012	Cadherin signaling pathway	P00475	Frizzled	MONDO|Ensembl=ENSMODG00000008701|UniProtKB=F6PWM3	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF22	FRIZZLED-3
P00054	Toll receptor signaling pathway	P01369	MKK1	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P06587	Nicotine pharmacodynamics pathway	P06606	ADCY2	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00916	Ras	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	IPI	22097630	PubMed	PTHR24070:SF189	GTPASE NRAS
P05915	Opioid proenkephalin pathway	P05994	G-protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00049	Parkinson disease	P01238	14-3-3	CANLF|Ensembl=ENSCAFG00000013549|UniProtKB=E2QVP6	Uncharacterized protein	ISS	1317796	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00006	Apoptosis signaling pathway	P00318	PKCs	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	IDA	2837282	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00057	Wnt signaling pathway	P01451	Galpha	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	IDA	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04393	Ras Pathway	P04546	GSK3	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	IDA	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00012	Cadherin signaling pathway	P00474	Wnt	MONDO|Ensembl=ENSMODG00000018415|UniProtKB=F6XUZ7	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	YEAST|SGD=S000005042|UniProtKB=P01120	Ras-like protein 2	ISS	7997267	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2520|UniProtKB=P61169	D(2) dopamine receptor	IDA	11861492	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	HUMAN|HGNC=4599|UniProtKB=Q14831	Metabotropic glutamate receptor 7	ISS	9407094	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00048	PI3 kinase pathway	P01192	p110	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	IGI	11292874	PubMed	PTHR10048:SF14	PI-3 KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	TAS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00056	VEGF signaling pathway	P01408	Akt/PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00922	Collagen	MACMU|Ensembl=ENSMMUG00000002935|UniProtKB=F7H1M7	Uncharacterized protein	ISS	10778855	PubMed	PTHR44057:SF2	COLLAGEN ALPHA-1 VIII  CHAIN
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P04380	Cortocotropin releasing factor receptor signaling pathway	P04453	ACTH	XENTR|Xenbase=XB-GENE-483703|UniProtKB=Q5M8F2	Proopiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P05913	Enkephalin release	P05972	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	TAS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TRIVA|Gene=TVAG_512800|UniProtKB=A2HNG1	Actin (Fragment)	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=98955|UniProtKB=P17553	Proto-oncogene Wnt-3	IDA	8717036	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P02738	De novo purine biosynthesis	P02909	GDP reductase	DICDI|dictyBase=DDB_G0272616|UniProtKB=P42521	Ribonucleoside-diphosphate reductase small subunit	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01444	Wnt	PANTR|Ensembl=ENSPTRG00000002064|UniProtKB=H2R817	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02918	dUTP pyrophosphatase	RAT|RGD=620849|UniProtKB=P70583	Deoxyuridine 5'-triphosphate nucleotidohydrolase	ISS			PTHR11241:SF6	DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE, MITOCHONDRIAL
P04393	Ras Pathway	P04579	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	7798194	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00047	PDGF signaling pathway	P01160	IP3 receptor	ANOGA|EnsemblGenome=AGAP006475|UniProtKB=Q5TQX0	AGAP006475-PA	ISS	4262086	gi	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CHICK|Ensembl=ENSGALG00000028102|UniProtKB=F1P3X4	Uncharacterized protein	IC	10938134	PubMed	PTHR13140:SF657	MYOSIN-4
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000024633|UniProtKB=F1MBU9	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04398	p53 pathway feedback loops 2	G04714	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	MONDO|Ensembl=ENSMODG00000020977|UniProtKB=F6S5B1	Uncharacterized protein (Fragment)	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P02723	Adenine and hypoxanthine salvage pathway	P02809	Xanthine dehydrogenase	PANTR|Ensembl=ENSPTRG00000011806|UniProtKB=H2QHQ2	Uncharacterized protein	ISS	8135849	PubMed	PTHR11908:SF80	XANTHINE DEHYDROGENASE/OXIDASE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MOUSE|MGI=MGI=97250|UniProtKB=P01108	Myc proto-oncogene protein	IEP	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P02763	Peptidoglycan biosynthesis	P03092	Phospho-N-acetylmuramoyl pentapeptide transferase	DEIRA|EnsemblGenome=DR_1835|UniProtKB=Q9RTD0	Phospho-N-acetylmuramoyl-pentapeptide-transferase	ISS			PTHR22926:SF5	PHOSPHO-N-ACETYLMURAMOYL-PENTAPEPTIDE-TRANSFERASE
P06210	Activin beta signaling pathway	P06229	PUT	DROME|Gene=Dmel_CG7904|UniProtKB=A0A0B4KG59	Serine/threonine-protein kinase receptor	IEA	9395284	PubMed	PTHR23255:SF70	SERINE/THREONINE-PROTEIN KINASE RECEPTOR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00006	Apoptosis signaling pathway	P00283	A1	MOUSE|MGI=MGI=1278326|UniProtKB=Q497M6	B-cell leukemia/lymphoma 2 related protein A1b	IGI	11964303	PubMed	PTHR11256:SF10	BCL-2-RELATED PROTEIN A1
P00029	Huntington disease	P00807	Actin	XENTR|GeneID=394982|UniProtKB=P20399	Actin, alpha cardiac muscle 2	ISS	14684598	PubMed	PTHR11937:SF263	ACTIN
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00050	Plasminogen activating cascade	P01253	Fibrin	HUMAN|HGNC=3694|UniProtKB=P02679	Fibrinogen gamma chain	IDA	80015086	PubMed	PTHR19143:SF338	FIBRINOGEN GAMMA CHAIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00049	Parkinson disease	P01211	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	IDA	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00024	Glycolysis	P00676	Glyceraldehyde 3-phosphate dehydrogenase	DROME|FlyBase=FBgn0001091|UniProtKB=P07486	Glyceraldehyde-3-phosphate dehydrogenase 1	RCA			PTHR10836:SF52	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	CHICK|Ensembl=ENSGALG00000003014|UniProtKB=P09481	Neuronal acetylcholine receptor subunit alpha-3	ISS	85270494	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02746	Heme biosynthesis	P02972	Ferrochelatase	ARATH|TAIR=AT2G30390|UniProtKB=O04921	Ferrochelatase-2, chloroplastic	ISS			PTHR11108:SF1	FERROCHELATASE, MITOCHONDRIAL
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05913	Enkephalin release	P05974	G-Protein (i)	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01145	c-fos	XENTR|Xenbase=XB-GENE-866811|UniProtKB=F7EI91	Uncharacterized protein (Fragment)	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00021	FGF signaling pathway	P00641	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00021	FGF signaling pathway	P00645	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	PANTR|Gene=HTR1F|UniProtKB=Q9N2D9	5-hydroxytryptamine receptor 1F (Fragment)	ISS	12441358	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000009766|UniProtKB=F6TFL4	Uncharacterized protein	ISS	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00018	EGF receptor signaling pathway	P00541	Spry	CHICK|Gene=SPRY2|UniProtKB=Q9PTL2	Protein sprouty homolog 2	IGI	99429807	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P00047	PDGF signaling pathway	P01164	PDK1/2	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	ISS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00020	FAS signaling pathway	P00615	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00052	TGF-beta signaling pathway	P01275	P38	BOVIN|Ensembl=ENSBTAG00000030182|UniProtKB=G3X793	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	YEAST|SGD=S000004690|UniProtKB=P0CF18	Uncharacterized protein YMR085W	ISS			PTHR10937:SF0	GH12731P-RELATED
P06959	CCKR signaling map	P07098	p46 SHC1	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	RCA	8900204	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	RAT|RGD=619965|UniProtKB=P26769	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000000985|UniProtKB=F6VRS9	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02783	Tryptophan biosynthesis	P03206	Anthranilate synthase	GLOVI|Gene=BAC88824|UniProtKB=Q7NM84	Anthranilate synthase component II	RCA			PTHR43418:SF4	MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	MOUSE|MGI=MGI=107471|UniProtKB=P31695	Neurogenic locus notch homolog protein 4	IDA	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P00037	Ionotropic glutamate receptor pathway	P01018	Glu1	PANTR|Ensembl=ENSPTRG00000017441|UniProtKB=H2QRU7	Glutamate receptor, ionotropic, AMPA 1	ISS	10331083	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	HALSA|EnsemblGenome=VNG_1204G|UniProtKB=Q9HQE1	Glutamate dehydrogenase A2	ISS			PTHR11606:SF13	GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	PANTR|Ensembl=ENSPTRG00000024326|UniProtKB=H2R231	Uncharacterized protein	ISS	11730323	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	1170702	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	TAKRU|Ensembl=ENSTRUG00000000584|UniProtKB=H2RMN2	Uncharacterized protein	ISS	11861492	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	PANTR|Ensembl=ENSPTRG00000023608|UniProtKB=H2QZZ2	Uncharacterized protein	ISS	14698601	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02747	Histidine biosynthesis	P02988	Histidinal dehydrogenase	BACTN|EnsemblGenome=BT_0201|UniProtKB=Q8ABA9	Histidinol dehydrogenase	ISS			PTHR21256:SF2	HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01202	p85	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01179	PKB	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	MOUSE|MGI=MGI=107471|UniProtKB=P31695	Neurogenic locus notch homolog protein 4	IDA	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P04393	Ras Pathway	P04542	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00219	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04393	Ras Pathway	P04578	Rho	CHICK|Ensembl=ENSGALG00000003806|UniProtKB=O93467	GTP-binding protein	ISS	12169092	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00008	Axon guidance mediated by Slit/Robo	P00352	DCC	CANLF|Ensembl=ENSCAFG00000000157|UniProtKB=F1PAZ4	Uncharacterized protein	ISS	12798294	PubMed	PTHR44146:SF3	NETRIN RECEPTOR DCC
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	BOVIN|Ensembl=ENSBTAG00000012628|UniProtKB=F1MUJ6	Uncharacterized protein	ISS	94365697	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00011	Blood coagulation	P00444	FIX	HUMAN|HGNC=3551|UniProtKB=P00740	Coagulation factor IX	ISS	182609	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00052	TGF-beta signaling pathway	P01284	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00981	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	IDA	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	AQUAE|EnsemblGenome=aq_1556|UniProtKB=O67507	Cysteine synthase	ISS			PTHR10314:SF100	CYSTEINE SYNTHASE B
P04393	Ras Pathway	P04565	MKK4/7	MOUSE|MGI=MGI=1346869|UniProtKB=P47809	Dual specificity mitogen-activated protein kinase kinase 4	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04393	Ras Pathway	P04569	Cdc42	MACMU|Ensembl=ENSMMUG00000022009|UniProtKB=F6RBZ7	Cell division control protein 42 homolog isoform 2	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	DROME|FlyBase=FBgn0001125|UniProtKB=Q8IPY3	Aspartate aminotransferase	ISS			PTHR11879:SF10	ASPARTATE AMINOTRANSFERASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	TAS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	BOVIN|Gene=CACNB1|UniProtKB=Q9MZL7	Voltage-dependent L-type calcium channel subunit beta-1	IDA	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	G04694	p110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	BACSU|EnsemblGenome=BSU01780|UniProtKB=P0CI73	Glutamine--fructose-6-phosphate aminotransferase [isomerizing]	ISS			PTHR10937:SF0	GH12731P-RELATED
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ORYSJ|EnsemblGenome=OS05G0438800|UniProtKB=Q75HX0	Actin	IDA	14684598	PubMed	PTHR11937:SF248	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00030	Hypoxia response via HIF activation	P00819	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00007	Axon guidance mediated by semaphorins	P00331	PAK	HUMAN|HGNC=8590|UniProtKB=Q13153	Serine/threonine-protein kinase PAK 1	ISS	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00925	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P06959	CCKR signaling map	G06973	FOS	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	RCA	12239223	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P05913	Enkephalin release	P05972	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ARATH|TAIR=AT4G36450|UniProtKB=O23236	Mitogen-activated protein kinase 14	IDA			PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P00012	Cadherin signaling pathway	P00471	Cadherin	ANOGA|EnsemblGenome=AGAP004850|UniProtKB=Q7PPU8	AGAP004850-PA	ISS	8120095	PubMed	PTHR24026:SF51	PROTOCADHERIN-LIKE WING POLARITY PROTEIN STAN
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	RCA	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00059	p53 pathway	G04694	p110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00049	Parkinson disease	P01227	20S proteasome	MACMU|Ensembl=ENSMMUG00000016446|UniProtKB=F7GF95	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF12	PROTEASOME SUBUNIT ALPHA TYPE-RELATED
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00053	T cell activation	P01318	PKC-theta	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IGI	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04398	p53 pathway feedback loops 2	P04665	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01472	Histone deacetylase	SCHPO|PomBase=SPAC3G9.07c|UniProtKB=O13298	Histone deacetylase phd1	IDA	10485845	PubMed	PTHR10625:SF132	HISTONE DEACETYLASE 3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P02734	Chorismate biosynthesis	P02871	2-Deoxy-7-phosphoheptulonate synthase	RHOBA|EnsemblGenome=RB12510|UniProtKB=Q7UII4	Phospho-2-dehydro-3-deoxyheptonate aldolase	ISS			PTHR21225:SF12	PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, PHE-SENSITIVE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PLAF7|EnsemblGenome=PF11_0147|UniProtKB=Q7KQK7	Mitogen-activated protein kinase	IGI	11559502	gi	PTHR24055:SF189	SUBFAMILY NOT NAMED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	XENTR|Xenbase=XB-GENE-491938|UniProtKB=Q6DIV8	Actin, alpha 1, skeletal muscle	ISS	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=1915409|UniProtKB=Q8R1Q0	Syntaxin-19	IC	11067767	PubMed	PTHR19957:SF29	SYNTAXIN-19
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00624	14-3-3	ANOGA|EnsemblGenome=AGAP001151|UniProtKB=Q7PX08	AGAP001151-PA	ISS	97302963	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	PANTR|Ensembl=ENSPTRG00000007576|UniProtKB=H2QA92	Uncharacterized protein	ISS			PTHR24229:SF20	SOMATOSTATIN RECEPTOR TYPE 5
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00568	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	IDA	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00012	Cadherin signaling pathway	P00470	F-actin	MOUSE|MGI=MGI=87905|UniProtKB=P68033	Actin, alpha cardiac muscle 1	IC	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04674	Mdm2	MACMU|Ensembl=ENSMMUG00000011236|UniProtKB=F6WXF0	Uncharacterized protein	ISS			PTHR13844:SF20	PROTEIN MDM4
P00049	Parkinson disease	P01211	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00047	PDGF signaling pathway	P01154	Ras	YEAST|SGD=S000005042|UniProtKB=P01120	Ras-like protein 2	ISS	7997267	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	AQUAE|EnsemblGenome=aq_1969|UniProtKB=O67781	Aspartate aminotransferase	ISS			PTHR11751:SF306	SUBFAMILY NOT NAMED
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	RCA	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00008	Axon guidance mediated by Slit/Robo	P00355	Rho	YEAST|SGD=S000006369|UniProtKB=P06780	GTP-binding protein RHO1	ISS			PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00057	Wnt signaling pathway	P01429	Axin	MOUSE|MGI=MGI=1096327|UniProtKB=O35625	Axin-1	ISS	9554852	PubMed	PTHR10845:SF11	AXIN-1
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02729	Ascorbate degradation	P02852	L-xylulose-5-phosphate-3-epimerase	RHOBA|EnsemblGenome=RB1561|UniProtKB=Q7UX51	Ribulose-phosphate 3-epimerase	ISS			PTHR11749:SF3	RIBULOSE-PHOSPHATE 3-EPIMERASE
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MOUSE|MGI=MGI=102522|UniProtKB=Q8R3Z5	Voltage-dependent L-type calcium channel subunit beta-1	IC	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	94280860	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00034	Integrin signalling pathway	P00916	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IPI	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P06664	Gonadotropin-releasing hormone receptor pathway	P06779	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	RCA	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00047	PDGF signaling pathway	P01174	Rho	YEAST|SGD=S000000464|UniProtKB=P38339	RHO GTPase-activating protein RGD1	ISS			PTHR23176:SF0	RHO GTPASE-ACTIVATING PROTEIN 68F
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00310	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01026	KA	CHICK|Ensembl=ENSGALG00000002098|UniProtKB=F1P0L4	Uncharacterized protein	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P02729	Ascorbate degradation	P02851	L-ribulose-5-phosphate-4-epimerase	ECOLI|EcoGene=EG10055|UniProtKB=P08203	L-ribulose-5-phosphate 4-epimerase	ISS	11732895	PubMed	PTHR22789:SF15	L-RIBULOSE-5-PHOSPHATE 4-EPIMERASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04372	5-Hydroxytryptamine degredation	P04401	Monoamine Oxidase	HUMAN|HGNC=6834|UniProtKB=P27338	Amine oxidase [flavin-containing] B	ISS	90344230	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	ISS	12039949	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00009	Axon guidance mediated by netrin	P00359	NFAT	MACMU|Ensembl=ENSMMUG00000012657|UniProtKB=F7E7J1	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00018	EGF receptor signaling pathway	P00564	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00018	EGF receptor signaling pathway	P00539	14-3-3	TAKRU|Ensembl=ENSTRUG00000004697|UniProtKB=H2SFG7	Uncharacterized protein	ISS	8381897	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	HUMAN|HGNC=10484|UniProtKB=Q92736	Ryanodine receptor 2	ISS	15858232	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00020	FAS signaling pathway	P00594	Caspase8	PANTR|Ensembl=ENSPTRG00000012801|UniProtKB=H2QJ86	Caspase 8, apoptosis-related cysteine peptidase	ISS	8681376	PubMed	PTHR10454:SF162	CASPASE-8
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MONDO|Ensembl=ENSMODG00000020977|UniProtKB=F6S5B1	Uncharacterized protein (Fragment)	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00045	Notch signaling pathway	P01103	Next	DANRE|ZFIN=ZDB-GENE-011128-2|UniProtKB=Q90Y57	Protein jagged-1a	ISS			PTHR44097:SF3	PROTEIN JAGGED-1
P02736	Coenzyme A biosynthesis	P02882	Pantothenate cysteine ligase	MACMU|Ensembl=ENSMMUG00000013126|UniProtKB=F6ZGL8	Uncharacterized protein	ISS			PTHR12290:SF2	PHOSPHOPANTOTHENATE--CYSTEINE LIGASE
P00049	Parkinson disease	P01230	Src kinase	MOUSE|MGI=MGI=96892|UniProtKB=P25911	Tyrosine-protein kinase Lyn	IDA	1371009	PubMed	PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P06959	CCKR signaling map	P07156	JAK2	HUMAN|HGNC=6192|UniProtKB=O60674	Tyrosine-protein kinase JAK2	RCA	22010007	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P05915	Opioid proenkephalin pathway	P05994	G-protein	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00030	Hypoxia response via HIF activation	P00821	Prolyl Hydroxylase	MOUSE|MGI=MGI=1932288|UniProtKB=Q91UZ4	Egl nine homolog 3	ISS	12912907	PubMed	PTHR12907:SF5	EGL NINE HOMOLOG 3
P00029	Huntington disease	P00790	beta-Tubulin	BOVIN|Ensembl=ENSBTAG00000006969|UniProtKB=Q2KJD0	Tubulin beta-5 chain	ISS	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MACMU|Ensembl=ENSMMUG00000023684|UniProtKB=P69895	Tubulin beta chain	ISS	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00006	Apoptosis signaling pathway	P00271	Bax	MOUSE|MGI=MGI=99702|UniProtKB=Q07813	Apoptosis regulator BAX	IDA	14963330	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P00034	Integrin signalling pathway	P00907	ERK	MONDO|Ensembl=ENSMODG00000009983|UniProtKB=F6USY2	Uncharacterized protein	ISS			PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05918	p38 MAPK pathway	P06025	SRF	MACMU|Ensembl=ENSMMUG00000000033|UniProtKB=F7G4D2	Uncharacterized protein	ISS	15647354	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	TAKRU|Ensembl=ENSTRUG00000003520|UniProtKB=H2S791	Uncharacterized protein	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00006	Apoptosis signaling pathway	P00260	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00944	Actin	MACMU|Ensembl=ENSMMUG00000001353|UniProtKB=F7D6T8	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P04393	Ras Pathway	P04567	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00012	Cadherin signaling pathway	P00462	Casein kinase II	MACMU|Ensembl=ENSMMUG00000015892|UniProtKB=F7BVK0	Uncharacterized protein	ISS	10806215	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02781	Threonine biosynthesis	P03189	Aspartate kinase	SCHPO|PomBase=SPBC776.03|UniProtKB=O94671	Probable homoserine dehydrogenase	ISS			PTHR43070:SF3	HOMOSERINE DEHYDROGENASE
P00006	Apoptosis signaling pathway	P00286	AIF	CANLF|Ensembl=ENSCAFG00000018747|UniProtKB=E2R541	Uncharacterized protein	ISS	9989411	PubMed	PTHR43557:SF4	APOPTOSIS-INDUCING FACTOR 1, MITOCHONDRIAL
P00046	Oxidative stress response	P01135	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	CANLF|Ensembl=ENSCAFG00000023650|UniProtKB=E2QWU0	Actin-related protein 2/3 complex subunit 4	ISS	9230079	PubMed	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	STRPU|Gene=CYIIIB|UniProtKB=P18499	Actin, cytoskeletal 3B	IC	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00558	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IGI	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-040718-93|UniProtKB=Q6DGZ5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Ensembl=ENSBTAG00000037726|UniProtKB=P10895	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	12860966	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00057	Wnt signaling pathway	P01448	CBP	ARATH|TAIR=AT1G79000|UniProtKB=Q9C5X9	Histone acetyltransferase HAC1	ISS	10823891	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00029	Huntington disease	P00807	Actin	CAEEL|WormBase=WBGene00000064|UniProtKB=P10984	Actin-2	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	BOVIN|Ensembl=ENSBTAG00000001067|UniProtKB=E1BAB4	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	ARATH|TAIR=AT5G58690|UniProtKB=Q944C2	Phosphoinositide phospholipase C 5	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IC	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	RAT|RGD=3238|UniProtKB=P01179	Oxytocin-neurophysin 1	ISS	3768139	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00034	Integrin signalling pathway	P00922	Collagen	CANLF|Ensembl=ENSCAFG00000000934|UniProtKB=E2RT85	Uncharacterized protein	ISS	10778855	PubMed	PTHR44557:SF1	COLLAGEN ALPHA-1 XIV  CHAIN
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DANRE|ZFIN=ZDB-GENE-030131-6206|UniProtKB=F1Q5K4	Uncharacterized protein	IEP	10938134	PubMed	PTHR13140:SF676	MYOSIN, HEAVY POLYPEPTIDE 2, FAST MUSCLE SPECIFIC
P05913	Enkephalin release	P05972	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P02722	Acetate utilization	P02802	Phosphate acetyltransferase	STRCO|EnsemblGenome=CAD55352|UniProtKB=Q8CJR5	Phosphate acetyltransferase	ISS			PTHR43356:SF3	PHOSPHATE ACETYLTRANSFERASE
P00012	Cadherin signaling pathway	P00470	F-actin	CAEBR|Gene=CBG18256|UniProtKB=A8XS95	Protein CBR-ACT-5	ISS	14684598	PubMed	PTHR11937:SF352	ACTIN
P04393	Ras Pathway	P04547	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00053	T cell activation	P01300	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IDA	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04396	Vitamin D metabolism and pathway	P04604	FdxR	SCHPO|PomBase=SPBC3B8.01c|UniProtKB=O59710	Probable NADPH:adrenodoxin oxidoreductase, mitochondrial	ISS			PTHR11938:SF91	NADPH:ADRENODOXIN OXIDOREDUCTASE, MITOCHONDRIAL
P00048	PI3 kinase pathway	P01177	P110ACT	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00128	Erb-B4	RAT|RGD=620486|UniProtKB=Q62956	Receptor tyrosine-protein kinase erbB-4	IDA	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=621005|UniProtKB=Q08849	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00887	IRS 1-4	MACMU|Ensembl=ENSMMUG00000019467|UniProtKB=F6SUL3	Uncharacterized protein	ISS	1311924	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	G04702	p53	PANTR|Ensembl=ENSPTRG00000015733|UniProtKB=H2QNY5	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=1197020|UniProtKB=O35468	Protein Wnt-9b	TAS	8717036	PubMed	PTHR12027:SF84	PROTEIN WNT-9B
P00006	Apoptosis signaling pathway	P00292	IkappaB	CHICK|Gene=NFKBIA|UniProtKB=Q91974	NF-kappa-B inhibitor alpha	ISS	10811867	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01162	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05918	p38 MAPK pathway	P06029	p38beta	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	RCA	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02738	De novo purine biosynthesis	P02909	GDP reductase	ECOLI|EcoGene=EG12381|UniProtKB=P37146	Ribonucleoside-diphosphate reductase 2 subunit beta	ISS			PTHR23409:SF32	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT BETA
P00048	PI3 kinase pathway	P01179	PKB	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	YEAST|SGD=S000000028|UniProtKB=P31109	Synaptobrevin homolog 1	IC			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P05916	Opioid prodynorphin pathway	P06000	vasopressin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	BOVIN|Ensembl=ENSBTAG00000002580|UniProtKB=F1MM57	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF462	MYOSIN-14
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MACMU|Ensembl=ENSMMUG00000006253|UniProtKB=F7H582	Uncharacterized protein	ISS	92357702	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P02755	Methylmalonyl pathway	P03033	Propionyl-CoA carboxylase	CANLF|Ensembl=ENSCAFG00000005838|UniProtKB=E2R518	Uncharacterized protein	ISS			PTHR18866:SF104	PROPIONYL-COA CARBOXYLASE ALPHA CHAIN, MITOCHONDRIAL
P00034	Integrin signalling pathway	P00906	Rap1	PANTR|Ensembl=ENSPTRG00000001102|UniProtKB=H2QZR9	RAP1A, member of RAS oncogene family	ISS	1904317	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00009	Axon guidance mediated by netrin	P00364	cdc42	MACMU|Ensembl=ENSMMUG00000022009|UniProtKB=F6RBZ7	Cell division control protein 42 homolog isoform 2	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00009	Axon guidance mediated by netrin	P00366	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12932731	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00010	B cell activation	P00398	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IGI	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00034	Integrin signalling pathway	P00925	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00006	Apoptosis signaling pathway	P00260	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00181	SHP2	BOVIN|Ensembl=ENSBTAG00000002048|UniProtKB=F1N339	Tyrosine-protein phosphatase non-receptor type	ISS	1382983	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00057	Wnt signaling pathway	P01444	Wnt	RAT|RGD=1308057|UniProtKB=F1M077	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P05918	p38 MAPK pathway	P06026	MEKK4	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS	602425	OMIM	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-050417-59|UniProtKB=Q15KE4	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00056	VEGF signaling pathway	P01419	Ets	MACMU|Ensembl=ENSMMUG00000020706|UniProtKB=F6PU72	Uncharacterized protein	ISS	15579511	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00048	PI3 kinase pathway	P01192	p110	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00807	Actin	ANOGA|EnsemblGenome=AGAP001676|UniProtKB=Q7PXZ8	AGAP001676-PA	IDA	10974003	PubMed	PTHR11937:SF368	ACTIN, INDIRECT FLIGHT MUSCLE
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01188	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000003762|UniProtKB=A5PJS1	GNB5 protein	ISS	10051575	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02738	De novo purine biosynthesis	P02894	IMP cyclohydrolase	AQUAE|EnsemblGenome=aq_1963|UniProtKB=O67775	Bifunctional purine biosynthesis protein PurH	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00048	PI3 kinase pathway	P01188	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00047	PDGF signaling pathway	P01164	PDK1/2	SCHPO|PomBase=SPCC576.15c|UniProtKB=Q12701	Serine/threonine-protein kinase ksg1	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00011	Blood coagulation	P00456	HCII	CHICK|Ensembl=ENSGALG00000001396|UniProtKB=F1NJ16	Uncharacterized protein	ISS	3132623	gi	PTHR11461:SF30	HEPARIN COFACTOR 2
P00047	PDGF signaling pathway	P01143	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	8946911	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00059	p53 pathway	P04609	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00633	Ras	DAPPU|EnsemblGenome=DAPPUDRAFT_301818|UniProtKB=E9I1I7	Putative uncharacterized protein	ISS	10684567	PubMed	PTHR24070:SF385	GTPASE HRAS
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IDA	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01401	HIF-1	PANTR|Ensembl=ENSPTRG00000006419|UniProtKB=H2Q8F3	Uncharacterized protein	ISS	14526383	PubMed	PTHR23043:SF7	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA
P00059	p53 pathway	P04633	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000013316|UniProtKB=H2QK23	Uncharacterized protein	ISS	12441358	PubMed	PTHR24229:SF52	SOMATOSTATIN RECEPTOR TYPE 4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PUCGT|EnsemblGenome=PGTG_05488|UniProtKB=E3K4I1	Actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	P01444	Wnt	BOVIN|Ensembl=ENSBTAG00000008097|UniProtKB=A4D7S0	Protein Wnt-2	ISS	8717036	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00048	PI3 kinase pathway	P01193	IRS	BOVIN|Ensembl=ENSBTAG00000021308|UniProtKB=F1MYE0	Uncharacterized protein	ISS	15110093	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IDA	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MOUSE|MGI=MGI=99675|UniProtKB=Q8VHH7	Adenylate cyclase type 3	IDA	12623444	PubMed	PTHR11920:SF291	ADENYLATE CYCLASE TYPE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	XENTR|Xenbase=XB-GENE-489222|UniProtKB=Q28GJ8	Ras homolog gene family, member A	ISS	15668138	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	IC	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	RCA	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	XENTR|Xenbase=XB-GENE-1011906|UniProtKB=F6XPD5	Uncharacterized protein (Fragment)	ISS			PTHR11824:SF8	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01305	Calmodulin	CHICK|Gene_ORFName=RCJMB04_24e7|UniProtKB=P62149	Calmodulin	ISS	9753452	PubMed	PTHR23050:SF311	CALMODULIN
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00046	Oxidative stress response	P01131	MKP5	MOUSE|MGI=MGI=1914853|UniProtKB=Q9DBB1	Dual specificity protein phosphatase 6	TAS			PTHR10159:SF45	DUAL SPECIFICITY PROTEIN PHOSPHATASE 6
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00036	Interleukin signaling pathway	P00985	PDK1/2	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	ISS	12855688	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00037	Ionotropic glutamate receptor pathway	P01018	Glu1	MACMU|Ensembl=ENSMMUG00000009287|UniProtKB=F7H3T9	Glutamate receptor 1 isoform 1	ISS	10331083	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	SCHPO|PomBase=SPAC1F7.05|UniProtKB=P36602	Ribonucleoside-diphosphate reductase large chain	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	BOVIN|Ensembl=ENSBTAG00000033153|UniProtKB=F1MG21	Uncharacterized protein	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P02724	Alanine biosynthesis	P02815	Branched chain amino acid aminotransferase	ORYSJ|EnsemblGenome=OS05G0558400|UniProtKB=Q6AT43	Branched-chain-amino-acid aminotransferase	ISS			PTHR42825:SF3	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	DROME|FlyBase=FBgn0260964|UniProtKB=Q8IH57	GH10249p	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00059	p53 pathway	G01579	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	IGI	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04455	beta-endorphin	MACMU|Ensembl=ENSMMUG00000016463|UniProtKB=F7GBI0	Uncharacterized protein	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	RAT|RGD=3187|UniProtKB=Q07008	Neurogenic locus notch homolog protein 1	IDA	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00053	T cell activation	P01312	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00021	FGF signaling pathway	P00629	PP2A	SCHPO|PomBase=SPAP8A3.09c|UniProtKB=Q9UT08	Protein phosphatase PP2A regulatory subunit A	ISS			PTHR10648:SF4	PROTEIN PHOSPHATASE 2  FORMERLY 2A , REGULATORY SUBUNIT A, BETA ISOFORM
P00036	Interleukin signaling pathway	P00996	STAT	PANTR|Ensembl=ENSPTRG00000009199|UniProtKB=H2QD19	Signal transducer and activator of transcription	ISS	8584036	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MOUSE|MGI=MGI=2155600|UniProtKB=Q91Z83	Myosin-7	ISS	89264452	PubMed	PTHR13140:SF344	MYOSIN-7
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	PANTR|Ensembl=ENSPTRG00000003502|UniProtKB=H2Q3E9	Uncharacterized protein	ISS	94365697	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	IDA	15737619	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05915	Opioid proenkephalin pathway	P05994	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00012	Cadherin signaling pathway	P00470	F-actin	RAT|RGD=1304556|UniProtKB=P63259	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00021	FGF signaling pathway	P00634	MEKK1-5	BOVIN|Ensembl=ENSBTAG00000004216|UniProtKB=F1MSX4	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00054	Toll receptor signaling pathway	P01355	AP1	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	CHICK|Gene=FZD10|UniProtKB=Q9PWH2	Frizzled-10	TAS	8717036	PubMed	PTHR11309:SF86	FRIZZLED-10
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	DANRE|Ensembl=ENSDARG00000015050|UniProtKB=Q6PI52	Calmodulin	ISS	10487978	PubMed	PTHR23050:SF326	CALMODULIN
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P06959	CCKR signaling map	P07157	p190RhoGEF	HUMAN|HGNC=30322|UniProtKB=Q8N1W1	Rho guanine nucleotide exchange factor 28	RCA	21224360	PubMed	PTHR12673:SF133	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 28
P00048	PI3 kinase pathway	P01192	p110	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01169	Vav	MOUSE|MGI=MGI=98923|UniProtKB=P27870	Proto-oncogene vav	ISS	14623913	PubMed	PTHR22826:SF112	PROTO-ONCOGENE VAV
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	TAS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05734	Synaptic vesicle trafficking	P05775	Synapsin	RAT|RGD=3798|UniProtKB=Q63537	Synapsin-2	TAS	600755	OMIM	PTHR10841:SF20	SYNAPSIN-2
P06959	CCKR signaling map	P07088	RYR1/2/3	HUMAN|HGNC=10484|UniProtKB=Q92736	Ryanodine receptor 2	RCA	2008014	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P05730	Endogenous cannabinoid signaling	P05751	Galpha	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00006	Apoptosis signaling pathway	P00275	Bak	PANTR|Ensembl=ENSPTRG00000018053|UniProtKB=H2R7E3	BCL2-antagonist/killer 1	ISS	7715730	PubMed	PTHR11256:SF41	BCL-2 HOMOLOGOUS ANTAGONIST/KILLER
P00018	EGF receptor signaling pathway	P00545	JNK1-3	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	HUMAN|HGNC=9508|UniProtKB=P49768	Presenilin-1	TAS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05938	RhoA	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	RCA	11360179	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000012036|UniProtKB=F7ALP1	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000035697|UniProtKB=Q28024	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IDA	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00049	Parkinson disease	P01226	CDCrel-1	ORNAN|Ensembl=ENSOANG00000011758|UniProtKB=F6T0Y1	Uncharacterized protein	ISS			PTHR18884:SF67	SEPTIN-2
P00046	Oxidative stress response	P01131	MKP5	HUMAN|HGNC=28161|UniProtKB=Q9BV47	Dual specificity protein phosphatase 26	ISS			PTHR10159:SF112	DUAL SPECIFICITY PROTEIN PHOSPHATASE 26
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	CAEEL|WormBase=WBGene00015778|UniProtKB=Q17994	Aspartate aminotransferase	ISS			PTHR11879:SF10	ASPARTATE AMINOTRANSFERASE
P00057	Wnt signaling pathway	P01443	Phospholipase C	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00057	Wnt signaling pathway	P01446	Calcineurin	RAT|RGD=3383|UniProtKB=P20651	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	IDA	12015605	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00269	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	IC	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	RCA	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00029	Huntington disease	P00786	ARF	ARATH|TAIR=AT1G70490|UniProtKB=P0DH91	ADP-ribosylation factor 2-B	ISS	12932731	PubMed	PTHR11711:SF225	ADP-RIBOSYLATION FACTOR 2-B
P00029	Huntington disease	P00786	ARF	PHYPA|Gene=PHYPADRAFT_193626|UniProtKB=A9TBY6	Arf1_5/ArfA-family small GTPase	ISS	12932731	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00011	Blood coagulation	P00421	alpha1-antitrypsin	HUMAN|HGNC=8941|UniProtKB=P01009	Alpha-1-antitrypsin	ISS	225768	gi	PTHR11461:SF165	ALPHA-1-ANTITRYPSIN-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01432	Beta-Catenin	BOVIN|Ensembl=ENSBTAG00000016420|UniProtKB=Q0VCX4	Catenin beta-1	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00053	T cell activation	P01311	Raf	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS			PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00060	Ubiquitin proteasome pathway	P01491	E2	DANRE|ZFIN=ZDB-GENE-030131-2735|UniProtKB=Q6PC58	Ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	ISS			PTHR24068:SF36	UBIQUITIN-CONJUGATING ENZYME E2 D1
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=99879|UniProtKB=Q62101	Serine/threonine-protein kinase D1	ISS	8078925	PubMed	PTHR22968:SF9	SERINE/THREONINE-PROTEIN KINASE D1
P00052	TGF-beta signaling pathway	P01275	P38	CAEEL|WormBase=WBGene00004055|UniProtKB=Q17446	Mitogen-activated protein kinase pmk-1	TAS	10851062	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04398	p53 pathway feedback loops 2	P04658	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	DANRE|ZFIN=ZDB-GENE-010705-1|UniProtKB=Q90Z40	Guanine nucleotide-binding protein subunit gamma	IDA	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MOUSE|MGI=MGI=95774|UniProtKB=Q8CGK7	Guanine nucleotide-binding protein G(olf) subunit alpha	IC			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01182	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00011	Blood coagulation	P00440	ATIII	HUMAN|HGNC=775|UniProtKB=P01008	Antithrombin-III	ISS	1082955	gi	PTHR11461:SF53	ANTITHROMBIN-III
P04393	Ras Pathway	P04569	Cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	97449291	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00054	Toll receptor signaling pathway	P01381	Ubc13	ORNAN|Ensembl=ENSOANG00000006626|UniProtKB=F6Q430	Uncharacterized protein	ISS			PTHR43902:SF2	UBIQUITIN-CONJUGATING ENZYME E2 N
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	HALSA|EnsemblGenome=VNG_1160G|UniProtKB=P61136	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00010	B cell activation	P00391	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01407	Erk	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05730	Endogenous cannabinoid signaling	P05751	Galpha	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00029	Huntington disease	P00805	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	DANRE|ZFIN=ZDB-GENE-040426-59|UniProtKB=Q6P045	Tyms protein	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00056	VEGF signaling pathway	P01407	Erk	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	RAT|RGD=1305626|UniProtKB=Q5U1X0	Transcription initiation factor TFIID subunit 11	ISS			PTHR13218:SF8	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11
P00037	Ionotropic glutamate receptor pathway	P01026	KA	HUMAN|HGNC=4580|UniProtKB=Q13002	Glutamate receptor ionotropic, kainate 2	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00034	Integrin signalling pathway	P00925	MEK	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P02786	Vitamin B6 biosynthesis	P03225	1-Deoxyxylulose-5-phosphate synthase	CHLTR|EnsemblGenome=CT_331|UniProtKB=O84335	1-deoxy-D-xylulose-5-phosphate synthase	ISS			PTHR43322:SF6	1-DEOXY-D-XYLULOSE-5-PHOSPHATE SYNTHASE
P05916	Opioid prodynorphin pathway	P06002	G-protein	ANOGA|EnsemblGenome=AGAP005773|UniProtKB=A0NEH6	AGAP005773-PA	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P02774	Salvage pyrimidine deoxyribonucleotides	P03146	Deoxyuridine kinase	HUMAN|HGNC=11830|UniProtKB=P04183	Thymidine kinase, cytosolic	ISS			PTHR11441:SF0	THYMIDINE KINASE, CYTOSOLIC
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=620023|UniProtKB=P10980	Muscarinic acetylcholine receptor M2	IDA	10069496	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P04393	Ras Pathway	P04567	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	MOUSE|MGI=MGI=95809|UniProtKB=P23819	Glutamate receptor 2	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	BOVIN|Ensembl=ENSBTAG00000011339|UniProtKB=A7MAZ4	Transcription initiation factor TFIID subunit 8	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00059	p53 pathway	G01563	MDM-2	BOVIN|Gene=MDM4|UniProtKB=Q2HJ21	Protein Mdm4	ISS			PTHR13844:SF20	PROTEIN MDM4
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MACMU|Ensembl=ENSMMUG00000012387|UniProtKB=F7EB20	Uncharacterized protein	ISS	8940199	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	IC	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	XENTR|Xenbase=XB-GENE-1005779|UniProtKB=F7E3I6	Uncharacterized protein	ISS	2137198	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00973	PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00391	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00015	Circadian clock system	G01501	cry	RAT|RGD=620935|UniProtKB=Q923I8	Cryptochrome-2	IDA	14507900	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P06664	Gonadotropin-releasing hormone receptor pathway	P06856	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	RCA	8051109	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P02783	Tryptophan biosynthesis	P03209	Anthranilate phosphoribosyl transferase	DEIRA|EnsemblGenome=DR_1767|UniProtKB=Q9RTJ5	Anthranilate phosphoribosyltransferase	ISS			PTHR43285:SF2	ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00047	PDGF signaling pathway	P01171	PLCgamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00010	B cell activation	P00371	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P02749	Leucine biosynthesis	P03002	Isopropylmalate isomerase	YEAST|SGD=S000002977|UniProtKB=P07264	3-isopropylmalate dehydratase	ISS			PTHR43822:SF3	3-ISOPROPYLMALATE DEHYDRATASE
P00059	p53 pathway	G04694	p110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01062	mGluR1	RAT|RGD=2742|UniProtKB=P23385	Metabotropic glutamate receptor 1	ISS	14614461	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P02769	Purine metabolism	P03117	5'-AMP Deaminase	RAT|RGD=2111|UniProtKB=O09178	AMP deaminase 3	ISS	1420359	PubMed	PTHR11359:SF2	AMP DEAMINASE 3
P00005	Angiogenesis	P00253	Axin	DANRE|ZFIN=ZDB-GENE-000403-2|UniProtKB=P57095	Axin-2	ISS	12356903	PubMed	PTHR10845:SF103	AXIN-2
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	IC	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P06664	Gonadotropin-releasing hormone receptor pathway	P06852	nPKCs	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	RCA	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00012	Cadherin signaling pathway	P00462	Casein kinase II	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g245041|UniProtKB=A7SG27	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00011	Blood coagulation	P00408	Plasminogen	HUMAN|HGNC=9071|UniProtKB=P00747	Plasminogen	ISS	130317	gi	PTHR24261:SF6	PLASMINOGEN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00029	Huntington disease	P00778	NMDA receptor	HUMAN|HGNC=4587|UniProtKB=Q14957	Glutamate receptor ionotropic, NMDA 2C	IDA	14698601	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00010	B cell activation	P00381	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00006	Apoptosis signaling pathway	P00314	MKK3	ORNAN|Ensembl=ENSOANG00000007732|UniProtKB=F6PXH5	Uncharacterized protein (Fragment)	ISS	97059154	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	BOVIN|Ensembl=ENSBTAG00000004279|UniProtKB=P61585	Transforming protein RhoA	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00011	Blood coagulation	P00417	TFPI	RAT|RGD=61914|UniProtKB=Q02445	Tissue factor pathway inhibitor	ISS	8394443	gi	PTHR10083:SF311	TISSUE FACTOR PATHWAY INHIBITOR
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	CANLF|Ensembl=ENSCAFG00000004381|UniProtKB=J9JH96	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02749	Leucine biosynthesis	P02999	2-Isopropylmalate synthase	AQUAE|EnsemblGenome=aq_2090|UniProtKB=O67862	2-isopropylmalate synthase	ISS			PTHR10277:SF9	2-ISOPROPYLMALATE SYNTHASE 1, CHLOROPLASTIC-RELATED
P00012	Cadherin signaling pathway	P00467	alpha-catenin	CANLF|Ensembl=ENSCAFG00000001315|UniProtKB=E2R9S7	Uncharacterized protein	ISS	1768802	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	RCA	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00047	PDGF signaling pathway	P01150	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	DROME|FlyBase=FBgn0263111|UniProtKB=P91645	Voltage-dependent calcium channel type A subunit alpha-1	ISS	8386525	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02748	Isoleucine biosynthesis	P02994	Branched chain amino acid aminotransferase	STRCO|EnsemblGenome=CAA19971|UniProtKB=O86505	Probable branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF44	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=1351338|UniProtKB=P97772	Metabotropic glutamate receptor 1	IDA			PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CAEEL|WormBase=WBGene00006454|UniProtKB=G5EEN8	AEX-4	IC			PTHR19305:SF10	AEX-4
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Gene=ACTG2|UniProtKB=P63270	Actin, gamma-enteric smooth muscle	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=12774|UniProtKB=P04628	Proto-oncogene Wnt-1	TAS	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04397	p53 pathway by glucose deprivation	G04706	TSC2	RAT|RGD=3908|UniProtKB=P49816	Tuberin	ISS	15249583	PubMed	PTHR10063:SF0	TUBERIN
P05731	GABA-B receptor II signaling	P05754	Ggamma	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05918	p38 MAPK pathway	P06033	TAB2	MONDO|Ensembl=ENSMODG00000016831|UniProtKB=F6R2J2	Uncharacterized protein	ISS			PTHR10351:SF27	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 2
P00006	Apoptosis signaling pathway	P00293	PKR	HUMAN|HGNC=9437|UniProtKB=P19525	Interferon-induced, double-stranded RNA-activated protein kinase	IDA	11555640	PubMed	PTHR11042:SF102	INTERFERON-INDUCED, DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE
P00019	Endothelin signaling pathway	P00586	Gq	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	ENTHI|EnsemblGenome=EHI_070730|UniProtKB=C4M5T0	Rho family GTPase	ISS			PTHR24072:SF117	RHO-RELATED PROTEIN RACC
P00005	Angiogenesis	P00238	Ras	CHICK|Ensembl=ENSGALG00000014033|UniProtKB=E1BTS2	Uncharacterized protein	ISS	3023884	PubMed	PTHR24070:SF186	GTPASE KRAS
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	PANTR|Ensembl=ENSPTRG00000012613|UniProtKB=H2QIY0	Uncharacterized protein	ISS	11907044	PubMed	PTHR44025:SF5	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00162	Pro-BACE-1	PANTR|Ensembl=ENSPTRG00000013924|UniProtKB=H2R1L7	Beta-site APP-cleaving enzyme 2	ISS			PTHR13683:SF262	BETA-SECRETASE 2
P04393	Ras Pathway	P04561	SRF	CANLF|Ensembl=ENSCAFG00000001829|UniProtKB=F1PH12	Uncharacterized protein	ISS	15170389	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P02781	Threonine biosynthesis	P03189	Aspartate kinase	CHLTR|EnsemblGenome=CT_362|UniProtKB=O84367	Aspartokinase	ISS			PTHR21499:SF38	ASPARTOKINASE 1, CHLOROPLASTIC
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04393	Ras Pathway	P04553	PAK	HUMAN|HGNC=8592|UniProtKB=O75914	Serine/threonine-protein kinase PAK 3	IDA	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MACMU|Ensembl=ENSMMUG00000000223|UniProtKB=F6XHK8	Uncharacterized protein	ISS	1608964	PubMed	PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P02738	De novo purine biosynthesis	P02905	Amidophosphoribosyl transferase	CANLF|Ensembl=ENSCAFG00000002217|UniProtKB=E2RF42	Amidophosphoribosyltransferase	ISS			PTHR11907:SF18	AMIDOPHOSPHORIBOSYLTRANSFERASE
P00034	Integrin signalling pathway	P00907	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	IDA	12471242	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00036	Interleukin signaling pathway	P00983	Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	IC	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00047	PDGF signaling pathway	P01168	PI3K	XENTR|Xenbase=XB-GENE-6085226|UniProtKB=F6ZM84	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	3045562	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04393	Ras Pathway	P04568	MKK3/6	BOVIN|Ensembl=ENSBTAG00000001609|UniProtKB=Q5E9X2	Dual specificity mitogen-activated protein kinase kinase 6	RCA			PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	XENTR|Xenbase=XB-GENE-6067221|UniProtKB=F6Z0J4	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	ARATH|TAIR=AT4G34460|UniProtKB=P49177	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF48	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA
P05731	GABA-B receptor II signaling	P05755	Gbeta	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	RCA	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P02748	Isoleucine biosynthesis	P02997	Acetolactate synthase	BOVIN|Gene=ILVBL|UniProtKB=A6QQT9	Acetolactate synthase-like protein	ISS			PTHR18968:SF155	ACETOLACTATE SYNTHASE-LIKE PROTEIN
P06664	Gonadotropin-releasing hormone receptor pathway	G06681	mPer1	MOUSE|MGI=MGI=1098283|UniProtKB=O35973	Period circadian protein homolog 1	RCA	12782655	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	HUMAN|HGNC=703|UniProtKB=Q92747	Actin-related protein 2/3 complex subunit 1A	ISS	12932731	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00057	Wnt signaling pathway	P01443	Phospholipase C	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00054	Toll receptor signaling pathway	P01375	JNK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00047	PDGF signaling pathway	P01148	Grb2	MACMU|Ensembl=ENSMMUG00000017477|UniProtKB=F6VIK2	Uncharacterized protein	ISS			PTHR12156:SF4	GRB2-ASSOCIATED-BINDING PROTEIN 2
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00021	FGF signaling pathway	P00645	Rac	CAEEL|WormBase=WBGene00004287|UniProtKB=Q94124	Ras-related protein rac-2	IGI	22392988	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IDA	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	TAS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P06959	CCKR signaling map	P07228	MAPK1/3	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	RCA	9230117	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P06959	CCKR signaling map	P07146	ELK1	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	RCA	10329725	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00049	Parkinson disease	P01211	ERK	SCLS1|EnsemblGenome=SS1G_05445|UniProtKB=A7EJF2	Mitogen-activated protein kinase	ISS			PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P02744	Fructose galactose metabolism	P02966	Hexokinase	HUMAN|HGNC=4923|UniProtKB=P52789	Hexokinase-2	RCA			PTHR19443:SF4	HEXOKINASE-2
P00053	T cell activation	P01336	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT3G59790|UniProtKB=Q9M1Z5	Mitogen-activated protein kinase 10	ISS	10851062	PubMed	PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P00011	Blood coagulation	P00438	Bradykinin	MACMU|Ensembl=ENSMMUG00000003700|UniProtKB=F6SG43	Uncharacterized protein	ISS	125507	gi	PTHR13814:SF12	KININOGEN-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	MOUSE|MGI=MGI=88397|UniProtKB=Q9ERZ4	Muscarinic acetylcholine receptor M2	ISS	91373358	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00047	PDGF signaling pathway	P01159	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00021	FGF signaling pathway	P00628	JNK1-3	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS			PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	PANTR|Ensembl=ENSPTRG00000019449|UniProtKB=H2QV01	Actin related protein 2/3 complex, subunit 1B, 41kDa	ISS	12473693	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00052	TGF-beta signaling pathway	P01287	BAMBI	RAT|RGD=621831|UniProtKB=Q91XN4	BMP and activin membrane-bound inhibitor homolog	TAS	10519551	PubMed	PTHR15505:SF1	BMP AND ACTIVIN MEMBRANE-BOUND INHIBITOR HOMOLOG
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	TAS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95811|UniProtKB=Q9Z2W8	Glutamate receptor 4	ISS	10331083	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00590	IP3 R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04393	Ras Pathway	P04541	p90RSK	ORNAN|Ensembl=ENSOANG00000010658|UniProtKB=F6V2V1	Uncharacterized protein	ISS	10558991	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00057	Wnt signaling pathway	P01443	Phospholipase C	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00011	Blood coagulation	P00437	Kallikrein	MOUSE|MGI=MGI=102849|UniProtKB=P26262	Plasma kallikrein	ISS	20072342	gi	PTHR44459:SF2	PLASMA KALLIKREIN
P04393	Ras Pathway	P04557	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	NAS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01153	GSK3	CAEEL|WormBase=WBGene00001746|UniProtKB=Q9U2Q9	Glycogen synthase kinase-3	ISS	11995474	gi	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00047	PDGF signaling pathway	P01153	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IDA	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04398	p53 pathway feedback loops 2	P04665	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02727	Androgen/estrogene/progesterone biosynthesis	P02829	Cholesterol acyltransferase	PANTR|Ensembl=ENSPTRG00000001728|UniProtKB=H2Q0P3	O-acyltransferase	ISS	7592824	PubMed	PTHR10408:SF6	STEROL O-ACYLTRANSFERASE 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00019	Endothelin signaling pathway	P00570	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	IDA	91072385	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01192	p110	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00464	Fyn	MOUSE|MGI=MGI=95602|UniProtKB=P39688	Tyrosine-protein kinase Fyn	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	BOVIN|Gene=CCR7|UniProtKB=Q5MD62	C-C chemokine receptor type 7	ISS	10941822	PubMed	PTHR10489:SF635	C-C CHEMOKINE RECEPTOR TYPE 7
P00057	Wnt signaling pathway	P01428	Frizzled	MACMU|Ensembl=ENSMMUG00000019399|UniProtKB=F6QFJ6	Frizzled-6	ISS	8717036	PubMed	PTHR11309:SF75	FRIZZLED-6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CRYNJ|EnsemblGenome=CNA04650|UniProtKB=Q5KP06	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00024	Glycolysis	P00672	Phosphofructokinase-1	AQUAE|EnsemblGenome=aq_1708|UniProtKB=O67605	ATP-dependent 6-phosphofructokinase	ISS	98196666	PubMed	PTHR13697:SF4	ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE
P00046	Oxidative stress response	P01131	MKP5	DROME|FlyBase=FBgn0039742|UniProtKB=Q9VAB0	IP21249p	ISS			PTHR10159:SF482	IP21249P
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	IC	14744463	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	15470041	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00018	EGF receptor signaling pathway	P00565	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00029	Huntington disease	P00797	p53	MACMU|Ensembl=ENSMMUG00000016466|UniProtKB=F7GBH1	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P02787	Vitamin B6 metabolism	P03236	Pyridoxamine phosphate oxidase	MYCTU|EnsemblGenome=Rv2607|UniProtKB=P9WIJ1	Pyridoxine/pyridoxamine 5'-phosphate oxidase	ISS	9634230	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	ISS	11319238	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00983	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	TAS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00009	Axon guidance mediated by netrin	P00364	cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00006	Apoptosis signaling pathway	P00269	MAPK	ORYSJ|EnsemblGenome=OS02G0148100|UniProtKB=Q6Z437	Mitogen-activated protein kinase 3	ISS	7341300	gi	PTHR24055:SF216	SUBFAMILY NOT NAMED
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	SCHMA|EnsemblGenome=Smp_020170|UniProtKB=G4V8E3	Voltage-dependent calcium channel (Fragment)	ISS	14624853	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P00012	Cadherin signaling pathway	P00470	F-actin	RAT|RGD=2027|UniProtKB=P63269	Actin, gamma-enteric smooth muscle	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	RCA	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00052	TGF-beta signaling pathway	P01288	FKBP12	SCHPO|PomBase=SPBC839.17c|UniProtKB=O42993	Peptidyl-prolyl cis-trans isomerase	ISS			PTHR10516:SF341	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05731	GABA-B receptor II signaling	P05754	Ggamma	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00029	Huntington disease	P00790	beta-Tubulin	PLAF7|EnsemblGenome=PF10_0084|UniProtKB=Q7KQL5	Tubulin beta chain	TAS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00005	Angiogenesis	P00219	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00899	IRS 1-4	CANLF|Ensembl=ENSCAFG00000010397|UniProtKB=E2RDB5	Uncharacterized protein	ISS	5031805	gi	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00046	Oxidative stress response	P01131	MKP5	BOVIN|Ensembl=ENSBTAG00000010279|UniProtKB=Q17QM8	Dual specificity protein phosphatase 14	ISS			PTHR10159:SF338	DUAL SPECIFICITY PROTEIN PHOSPHATASE 14
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MONDO|Ensembl=ENSMODG00000020977|UniProtKB=F6S5B1	Uncharacterized protein (Fragment)	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00057	Wnt signaling pathway	P01438	PP2A	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00020	FAS signaling pathway	P00615	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	MONDO|Ensembl=ENSMODG00000001626|UniProtKB=F6TN69	Uncharacterized protein (Fragment)	ISS	15226293	PubMed	PTHR13715:SF16	RYANODINE RECEPTOR 3
P00049	Parkinson disease	P01242	Casein kinase I	SCHPO|PomBase=SPAC23C4.12|UniProtKB=P40236	Casein kinase I homolog hhp2	IDA	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00012	Cadherin signaling pathway	P00470	F-actin	HUMAN|HGNC=169|UniProtKB=P61160	Actin-related protein 2	ISS	10974003	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Gene=PCDH11X|UniProtKB=Q71M42	Protocadherin-11 X-linked	ISS	8120095	PubMed	PTHR43912:SF1	PROTOCADHERIN-11 X-LINKED-RELATED
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9441|UniProtKB=P51817	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IGI	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	IDA	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00049	Parkinson disease	P01227	20S proteasome	YEAST|SGD=S000005683|UniProtKB=P25043	Proteasome subunit beta type-2	TAS	12859888	PubMed	PTHR11599:SF44	AT05866P-RELATED
P00021	FGF signaling pathway	P00629	PP2A	CHICK|Ensembl=ENSGALG00000009828|UniProtKB=E1C5A3	Uncharacterized protein	ISS	12110603	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Ensembl=ENSPTRG00000011042|UniProtKB=H2QGF5	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00057	Wnt signaling pathway	P01438	PP2A	CHICK|Ensembl=ENSGALG00000010273|UniProtKB=P48463	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P02747	Histidine biosynthesis	P02992	Imidazol glycerol phosphate synthase	METAC|EnsemblGenome=MA_0913|UniProtKB=Q8TS91	Imidazole glycerol phosphate synthase subunit HisH	ISS			PTHR42701:SF2	SUBFAMILY NOT NAMED
P06959	CCKR signaling map	G06977	PAI2	HUMAN|HGNC=8584|UniProtKB=P05120	Plasminogen activator inhibitor 2	RCA	19074642	PubMed	PTHR11461:SF61	PLASMINOGEN ACTIVATOR INHIBITOR 2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02746	Heme biosynthesis	P02972	Ferrochelatase	DROME|FlyBase=FBgn0266268|UniProtKB=Q9V9S8	Ferrochelatase, mitochondrial	ISS			PTHR11108:SF1	FERROCHELATASE, MITOCHONDRIAL
P00010	B cell activation	P00375	Calmodulin	MACMU|Ensembl=ENSMMUG00000028962|UniProtKB=F7EWG5	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF322	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02772	Pyruvate metabolism	P03132	Pyruvate Kinase	BOVIN|Ensembl=ENSBTAG00000001601|UniProtKB=A5D984	Pyruvate kinase	ISS	8193145	PubMed	PTHR11817:SF15	PYRUVATE KINASE PKM
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00057	Wnt signaling pathway	P01469	Dapper	XENTR|Xenbase=XB-GENE-478639|UniProtKB=Q66KC9	Dapper 1	ISS	11941372	PubMed	PTHR15919:SF12	DAPPER HOMOLOG 1
P00011	Blood coagulation	P00433	uPAR	HUMAN|HGNC=9053|UniProtKB=Q03405	Urokinase plasminogen activator surface receptor	ISS	1689240	PubMed	PTHR10624:SF6	UROKINASE PLASMINOGEN ACTIVATOR SURFACE RECEPTOR
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00475	Frizzled	CHICK|Gene=FZD7|UniProtKB=O57329	Frizzled-7	IDA	8717036	PubMed	PTHR11309:SF31	FRIZZLED-7
P02763	Peptidoglycan biosynthesis	P03091	D-alanine-D-alanine ligase	THEMA|EnsemblGenome=TM_0259|UniProtKB=P46805	D-alanine--D-alanine ligase	ISS			PTHR23132:SF12	D-ALANINE--D-ALANINE LIGASE B
P00021	FGF signaling pathway	P00648	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	IGI	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00057	Wnt signaling pathway	P01465	Ggamma	BOVIN|Ensembl=ENSBTAG00000003043|UniProtKB=P63212	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00053	T cell activation	P01318	PKC-theta	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000002647|UniProtKB=F7DIB7	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00047	PDGF signaling pathway	P01173	STAT	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	14984365	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00034	Integrin signalling pathway	P00944	Actin	RAT|RGD=1304556|UniProtKB=P63259	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00049	Parkinson disease	P01239	Cul-1	RAT|RGD=1308157|UniProtKB=B1WBY1	Cul1 protein	ISS	12628165	PubMed	PTHR11932:SF81	CULLIN-1
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	IC	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00562	p38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IGI	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	RAT|RGD=1311443|UniProtKB=D3Z8L7	Ras-related protein R-Ras	ISS	7997267	PubMed	PTHR24070:SF245	RAS-RELATED PROTEIN R-RAS
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	PANTR|Ensembl=ENSPTRG00000015241|UniProtKB=Q5IS72	D(3) dopamine receptor	ISS	2137198	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00208	MEKK1	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	ISS	12168099	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00640	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	14505573	PubMed	PTHR10048:SF14	PI-3 KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	XENTR|Xenbase=XB-GENE-976753|UniProtKB=Q0VFR6	Syntaxin 1A (Brain)	ISS	1321498	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00034	Integrin signalling pathway	P00909	ASAP1	BOVIN|Gene=ASAP1|UniProtKB=O97902	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1	RCA			PTHR23180:SF192	ARF-GAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	RAT|RGD=61862|UniProtKB=P19491	Glutamate receptor 2	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	CHICK|Gene=CTNNA2|UniProtKB=P30997	Catenin alpha-2	TAS	1768802	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	CHICK|Ensembl=ENSGALG00000028102|UniProtKB=F1P3X4	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF657	MYOSIN-4
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	RCA	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00564	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	10891487	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=69350|UniProtKB=D3ZE55	Protocadherin-8	ISS	8120095	PubMed	PTHR24028:SF46	PROTOCADHERIN-8
P00012	Cadherin signaling pathway	P00475	Frizzled	HUMAN|HGNC=4046|UniProtKB=Q9H461	Frizzled-8	IDA	8717036	PubMed	PTHR11309:SF90	FRIZZLED-8
P00019	Endothelin signaling pathway	P00568	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	IGI	11591316	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00047	PDGF signaling pathway	P01160	IP3 receptor	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00021	FGF signaling pathway	P00636	FGFR1-4	RAT|RGD=620714|UniProtKB=A0A0G2K210	Fibroblast growth factor receptor	IGI	12441294	PubMed	PTHR24416:SF505	FIBROBLAST GROWTH FACTOR RECEPTOR 3
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00018	EGF receptor signaling pathway	P00546	GAP	PANTR|Ensembl=ENSPTRG00000008970|UniProtKB=H2QCM0	Neurofibromin 1	ISS	95047432	PubMed	PTHR10194:SF60	NEUROFIBROMIN
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CHICK|Ensembl=ENSGALG00000011809|UniProtKB=F1NMB0	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00057	Wnt signaling pathway	P01427	Naked	HUMAN|HGNC=17046|UniProtKB=Q969F2	Protein naked cuticle homolog 2	ISS	11356022	PubMed	PTHR22611:SF1	PROTEIN NAKED CUTICLE HOMOLOG 2
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	IC	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00006	Apoptosis signaling pathway	P00322	Cytochrome C	CANLF|Ensembl=ENSCAFG00000002856|UniProtKB=P00011	Cytochrome c	ISS	4347193	PubMed	PTHR11961:SF15	CYTOCHROME C
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	PHYIT|EnsemblGenome=PITG_06514|UniProtKB=D0N511	Calmodulin	ISS	7514101	PubMed	PTHR23050:SF245	AT16150P-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MONDO|Ensembl=ENSMODG00000005623|UniProtKB=F7CFG8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00019	Endothelin signaling pathway	P00587	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00005	Angiogenesis	P00228	Grb7	MOUSE|MGI=MGI=102683|UniProtKB=Q03160	Growth factor receptor-bound protein 7	ISS	10521483	PubMed	PTHR11243:SF25	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 7
P04398	p53 pathway feedback loops 2	G04714	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00752	cGMP-gated ion channel	BOVIN|Ensembl=ENSBTAG00000009834|UniProtKB=Q29441	Cyclic nucleotide-gated cation channel alpha-3	IDA	12432397	PubMed	PTHR10217:SF390	CYCLIC NUCLEOTIDE-GATED CATION CHANNEL ALPHA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DANRE|ZFIN=ZDB-GENE-000329-3|UniProtKB=Q7ZVF9	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P05913	Enkephalin release	P05978	AC	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00563	Gab	HUMAN|HGNC=14458|UniProtKB=Q9UQC2	GRB2-associated-binding protein 2	IGI	18105042	gi	PTHR12156:SF4	GRB2-ASSOCIATED-BINDING PROTEIN 2
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04413	K+ channel	CHICK|Ensembl=ENSGALG00000016193|UniProtKB=E1BYI0	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MONDO|Ensembl=ENSMODG00000016595|UniProtKB=F6ZDB2	Uncharacterized protein	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00034	Integrin signalling pathway	P00948	Rho	BOVIN|Ensembl=ENSBTAG00000004279|UniProtKB=P61585	Transforming protein RhoA	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00053	T cell activation	P01298	NFkappaB	CHICK|Ensembl=ENSGALG00000012304|UniProtKB=Q04861	Nuclear factor NF-kappa-B p105 subunit	IGI	12574369	PubMed	PTHR24169:SF9	NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04393	Ras Pathway	P04578	Rho	CAEEL|WormBase=WBGene00004357|UniProtKB=Q22038	Ras-like GTP-binding protein rhoA	IDA	11973360	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00008	Axon guidance mediated by Slit/Robo	P00351	Cxcr4	CANLF|Ensembl=ENSCAFG00000005109|UniProtKB=Q3LSL6	C-X-C chemokine receptor type 4	ISS	11943720	PubMed	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MACMU|Ensembl=ENSMMUG00000010380|UniProtKB=F7D9M6	Uncharacterized protein	ISS	10915626	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00634	MEKK1-5	RAT|RGD=620966|UniProtKB=Q62925	Mitogen-activated protein kinase kinase kinase 1	IGI	12049732	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00012	Cadherin signaling pathway	P00463	betacatenin	DANRE|ZFIN=ZDB-GENE-040426-2575|UniProtKB=E7FC99	Uncharacterized protein	ISS	15001769	PubMed	PTHR23315:SF68	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00951	Jnk	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00049	Parkinson disease	P01211	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	MOUSE|MGI=MGI=99473|UniProtKB=Q8BWG8	Beta-arrestin-1	ISS	4757780	gi	PTHR11792:SF22	BETA-ARRESTIN-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00053	T cell activation	P01336	Jnk	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000000365|UniProtKB=F6R9F4	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00030	Hypoxia response via HIF activation	P00823	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00778	NMDA receptor	DANRE|ZFIN=ZDB-GENE-051202-1|UniProtKB=E7F101	Uncharacterized protein	ISS	11554554	PubMed	PTHR44391:SF2	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	HUMAN|HGNC=5293|UniProtKB=P28223	5-hydroxytryptamine receptor 2A	ISS	11859080	PubMed	PTHR24247:SF30	5-HYDROXYTRYPTAMINE RECEPTOR 2A
P00023	General transcription regulation	P00663	TFIIFalpha	XENTR|Xenbase=XB-GENE-974834|UniProtKB=B1H3B7	LOC100124929 protein	ISS			PTHR13011:SF0	GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00256	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P05731	GABA-B receptor II signaling	P05755	Gbeta	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	RCA	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P02723	Adenine and hypoxanthine salvage pathway	P02804	Hypoxanthine phosphoribosyl transferase	CANLF|Gene=HPRT1|UniProtKB=Q6WIT9	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF6	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	RAT|RGD=2738|UniProtKB=Q00960	Glutamate receptor ionotropic, NMDA 2B	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00570	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01062	mGluR1	MOUSE|MGI=MGI=1351338|UniProtKB=P97772	Metabotropic glutamate receptor 1	ISS	12351712	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	HUMAN|HGNC=1076|UniProtKB=P36894	Bone morphogenetic protein receptor type-1A	TAS	9395284	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P00047	PDGF signaling pathway	P01162	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P05916	Opioid prodynorphin pathway	P06002	G-protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	LEIMA|EnsemblGenome=LmjF.34.0120|UniProtKB=Q4Q3J6	Adenylate kinase 2	ISS			PTHR23359:SF143	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01447	Dishevelled	PANTR|Gene=DVL1|UniProtKB=Q5IS48	Segment polarity protein dishevelled homolog DVL-1	ISS	11212302	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00060	Ubiquitin proteasome pathway	P01490	E3	RAT|RGD=1359327|UniProtKB=Q5U300	Ubiquitin-like modifier-activating enzyme 1	ISS			PTHR10953:SF155	UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 1
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=2136745|UniProtKB=Q91VE5	Protein Pcdhb10	IDA	8120095	PubMed	PTHR24028:SF90	PROTOCADHERIN BETA-5
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	ISS	11319238	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04393	Ras Pathway	P04555	PDK	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	9094314	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	RAT|RGD=621109|UniProtKB=O88321	Antisecretory factor	ISS	11827521	PubMed	PTHR10223:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4
P00057	Wnt signaling pathway	P01452	NFAT	MOUSE|MGI=MGI=1920431|UniProtKB=Q8K120	Nuclear factor of activated T-cells, cytoplasmic 4	IDA	12015605	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=1351339|UniProtKB=Q14BI2	Metabotropic glutamate receptor 2	ISS	12351712	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00005	Angiogenesis	P00234	Grb2	DROME|FlyBase=FBgn0004638|UniProtKB=Q08012	Protein enhancer of sevenless 2B	ISS			PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04384	Gamma-aminobutyric acid synthesis	P04480	GABA aminotransferase	HUMAN|HGNC=23|UniProtKB=P80404	4-aminobutyrate aminotransferase, mitochondrial	ISS	8133261	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P05731	GABA-B receptor II signaling	P05752	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00057	Wnt signaling pathway	P01435	SWI/SNF	XENTR|Xenbase=XB-GENE-491104|UniProtKB=F6VTC2	Uncharacterized protein (Fragment)	ISS	11532957	PubMed	PTHR13844:SF1	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D MEMBER 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00025	Hedgehog signaling pathway	P00682	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	IDA	176892	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P02746	Heme biosynthesis	P02981	Glutamate-1-semialdehyde aminotransferase	ECOLI|EcoGene=EG10432|UniProtKB=P23893	Glutamate-1-semialdehyde 2,1-aminomutase	ISS			PTHR43713:SF3	GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00053	T cell activation	P01300	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MOUSE|MGI=MGI=102522|UniProtKB=Q8R3Z5	Voltage-dependent L-type calcium channel subunit beta-1	IC	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00045	Notch signaling pathway	P01114	Ntm	PANTR|Ensembl=ENSPTRG00000034379|UniProtKB=H2RDK4	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Ensembl=ENSPTRG00000013825|UniProtKB=H2RAK4	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00012	Cadherin signaling pathway	P00466	EGFR	ORNAN|Ensembl=ENSOANG00000007021|UniProtKB=F7GAV2	Receptor protein-tyrosine kinase	ISS	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00053	T cell activation	P01324	rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	20264070	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MOUSE|MGI=MGI=99674|UniProtKB=Q91WF3	Adenylate cyclase type 4	IDA	2491850	PubMed	PTHR11920:SF286	ADENYLATE CYCLASE TYPE 4
P00053	T cell activation	P01311	Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	IDA	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00021	FGF signaling pathway	P00628	JNK1-3	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00048	PI3 kinase pathway	P01200	SHIP	CHICK|Ensembl=ENSGALG00000010493|UniProtKB=F1NNK7	Uncharacterized protein	ISS			PTHR12997:SF2	TYPE I INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE
P00019	Endothelin signaling pathway	P00586	Gq	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05731	GABA-B receptor II signaling	P05752	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	RCA	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00005	Angiogenesis	P00193	SOS-1	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05918	p38 MAPK pathway	P06031	p38alpha	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	CHICK|Ensembl=ENSGALG00000017238|UniProtKB=F1NWG3	Uncharacterized protein	ISS	92317054	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P04378	Beta2 adrenergic receptor signaling pathway	P04440	Beta2	MOUSE|MGI=MGI=87938|UniProtKB=P18762	Beta-2 adrenergic receptor	ISS	12063255	PubMed	PTHR24248:SF21	BETA-2 ADRENERGIC RECEPTOR
P00047	PDGF signaling pathway	P01173	STAT	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	15825084	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00029	Huntington disease	P00807	Actin	MACMU|Ensembl=ENSMMUG00000001353|UniProtKB=F7D6T8	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00049	Parkinson disease	P01211	ERK	DICDI|dictyBase=DDB_G0283903|UniProtKB=Q54QB1	Extracellular signal-regulated kinase 2	IDA	gi:1362216	gi	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IC	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01446	Calcineurin	XENTR|Xenbase=XB-GENE-948794|UniProtKB=Q6VN50	Protein phospatase 3 regulatory subunit B alpha isoform type 1	ISS	12015605	PubMed	PTHR23056:SF4	PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06836	PG Rcs	MOUSE|MGI=MGI=97793|UniProtKB=P35375	Prostaglandin E2 receptor EP1 subtype	RCA	14607241	PubMed	PTHR11866:SF3	PROSTAGLANDIN E2 RECEPTOR EP1 SUBTYPE
P04395	Vasopressin synthesis	P04596	Endo Peptidase	GLOVI|Gene=BAC88070|UniProtKB=Q7NPC6	Oligopeptidase	IC			PTHR11757:SF3	PROTEASE 2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	1504106	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00780	Microtubule	LEIMA|EnsemblGenome=LmjF.33.0792|UniProtKB=Q4Q4C4	Beta tubulin	IDA	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00046	Oxidative stress response	P01129	JNK1/2	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	MOUSE|MGI=MGI=87906|UniProtKB=P63260	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P06959	CCKR signaling map	P07090	MAPK8-10	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	RCA	12193476	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00925	MEK	MONDO|Ensembl=ENSMODG00000001404|UniProtKB=F7BD74	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00006	Apoptosis signaling pathway	P00274	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	BOVIN|Ensembl=ENSBTAG00000018445|UniProtKB=E1BK87	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00780	Microtubule	CHICK|Ensembl=ENSGALG00000027684|UniProtKB=P09653	Tubulin beta-5 chain	IDA	12932731	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P05916	Opioid prodynorphin pathway	P06002	G-protein	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00007	Axon guidance mediated by semaphorins	P00340	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00049	Parkinson disease	P01238	14-3-3	CHICK|Ensembl=ENSGALG00000006743|UniProtKB=Q5ZKJ2	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00049	Parkinson disease	P01230	Src kinase	CHICK|Gene=FYN|UniProtKB=Q05876	Tyrosine-protein kinase Fyn	IDA	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00053	T cell activation	P01335	jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00036	Interleukin signaling pathway	P00977	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00006	Apoptosis signaling pathway	P00269	MAPK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	93028473	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05913	Enkephalin release	P05976	Enkephalin	PANTR|Ensembl=ENSPTRG00000020270|UniProtKB=H2QW70	Proenkephalin	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P02780	Thiamin metabolism	P03184	Thiamine triphosphatase	MOUSE|MGI=MGI=2446078|UniProtKB=Q8JZL3	Thiamine-triphosphatase	IEA	12466851	PubMed	PTHR14586:SF1	THIAMINE-TRIPHOSPHATASE
P00034	Integrin signalling pathway	P00907	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00054	Toll receptor signaling pathway	P01369	MKK1	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00053	T cell activation	P01319	PAK	RAT|RGD=3251|UniProtKB=Q62829	Serine/threonine-protein kinase PAK 3	IDA	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00006	Apoptosis signaling pathway	P00274	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	ANOGA|EnsemblGenome=AGAP000776|UniProtKB=Q7QE85	AGAP000776-PA	IC			PTHR13140:SF706	UNCONVENTIONAL MYOSIN-VI
P00003	Alzheimer disease-amyloid secretase pathway	P00091	Aph-1	MACMU|Ensembl=ENSMMUG00000017856|UniProtKB=F7DK04	Uncharacterized protein	ISS	12763021	PubMed	PTHR12889:SF1	GAMMA-SECRETASE SUBUNIT APH-1B
P00005	Angiogenesis	P00249	PAK	PANTR|Ensembl=ENSPTRG00000022187|UniProtKB=Q7YQL4	Serine/threonine-protein kinase PAK 3	ISS	11259591	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00029	Huntington disease	P00780	Microtubule	EMENI|EnsemblGenome=CADANIAG00007636|UniProtKB=P10874	Tubulin beta-2 chain	IDA	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00047	PDGF signaling pathway	P01159	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05915	Opioid proenkephalin pathway	P05994	G-protein	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00019	Endothelin signaling pathway	P00589	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	RCA	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00056	VEGF signaling pathway	P01412	HSP27	CANLF|Ensembl=ENSCAFG00000014074|UniProtKB=E2RNB6	Uncharacterized protein	ISS			PTHR11527:SF37	ALPHA-CRYSTALLIN B CHAIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02746	Heme biosynthesis	P02970	Coproporphyrinogen oxidase (oxygen independent)	IXOSC|EnsemblGenome=ISCW020759|UniProtKB=B7PXP0	Coproporphyrinigen III oxidase, putative (Fragment)	ISS			PTHR13932:SF14	RADICAL S-ADENOSYL METHIONINE DOMAIN-CONTAINING PROTEIN 1, MITOCHONDRIAL
P00048	PI3 kinase pathway	P01197	Caspase-9	MACMU|Ensembl=ENSMMUG00000018163|UniProtKB=F7FNC1	Caspase	ISS	11440972	PubMed	PTHR10454:SF157	CASPASE-9
P00047	PDGF signaling pathway	P01158	PDGF receptor A	RAT|RGD=1308028|UniProtKB=Q5RJP7	Platelet-derived growth factor receptor-like protein	ISS			PTHR15360:SF1	PLATELET-DERIVED GROWTH FACTOR RECEPTOR-LIKE PROTEIN
P00012	Cadherin signaling pathway	P00475	Frizzled	HUMAN|HGNC=4040|UniProtKB=Q14332	Frizzled-2	IDA	11212302	PubMed	PTHR11309:SF34	FRIZZLED-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=94926|UniProtKB=P51436	D(4) dopamine receptor	IDA	11861492	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00023	General transcription regulation	P00658	TBP-associated factors	MACMU|Ensembl=ENSMMUG00000014702|UniProtKB=F7GSG6	Transcription initiation factor TFIID subunit 2	ISS			PTHR15137:SF9	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2
P04398	p53 pathway feedback loops 2	G04714	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00029	Huntington disease	P00790	beta-Tubulin	MONDO|Ensembl=ENSMODG00000017213|UniProtKB=F6WYK8	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01435	SWI/SNF	SCHPO|PomBase=SPAC11E3.01c|UniProtKB=O13682	Helicase swr1	IDA	11532957	PubMed	PTHR10799:SF832	HELICASE DOMINO
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	RAT|RGD=2731|UniProtKB=P63003	Amino-terminal enhancer of split	ISS	9783586	PubMed	PTHR10814:SF4	AMINO-TERMINAL ENHANCER OF SPLIT-RELATED
P00057	Wnt signaling pathway	P01440	Cadherin	CANLF|Ensembl=ENSCAFG00000006532|UniProtKB=F6Y4F1	Uncharacterized protein	ISS	8120095	PubMed	PTHR43956:SF6	PROTOCADHERIN-16
P00057	Wnt signaling pathway	P01454	betaTrCP	TAKRU|Ensembl=ENSTRUG00000001126|UniProtKB=H2RR47	Uncharacterized protein	ISS	10074433	PubMed	PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P00012	Cadherin signaling pathway	P00474	Wnt	CHICK|Gene=WNT2B|UniProtKB=Q98SN7	Protein Wnt-2b	IDA	8717036	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PRIPA|Gene=PPA17339|UniProtKB=H3F5B4	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF352	ACTIN
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	DEIRA|EnsemblGenome=DR_0980|UniProtKB=Q9RVP5	Glutamate dehydrogenase	ISS			PTHR11606:SF13	GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL
P00047	PDGF signaling pathway	P01151	PKB	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00748	Gbeta5L	DANRE|ZFIN=ZDB-GENE-070112-342|UniProtKB=A1L271	Uncharacterized protein	ISS	10051575	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	PANTR|Ensembl=ENSPTRG00000004701|UniProtKB=H2Q5G9	Low density lipoprotein receptor-related protein 6	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00053	T cell activation	P01322	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04633	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01162	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02777	Succinate to proprionate conversion	P03163	Methylmalonyl-CoA decarboxylase	BOVIN|Ensembl=ENSBTAG00000015221|UniProtKB=Q2TBR0	Propionyl-CoA carboxylase beta chain, mitochondrial	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	HUMAN|HGNC=14656|UniProtKB=Q8TD84	Down syndrome cell adhesion molecule-like protein 1	ISS			PTHR44107:SF3	DOWN SYNDROME CELL ADHESION MOLECULE-LIKE PROTEIN 1
P06959	CCKR signaling map	P07134	PKCdelta	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	RCA	12740336	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00047	PDGF signaling pathway	P01155	Jak	MOUSE|MGI=MGI=99928|UniProtKB=Q62137	Tyrosine-protein kinase JAK3	ISS	15179321	PubMed	PTHR24418:SF233	TYROSINE-PROTEIN KINASE JAK3
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	CANLF|Ensembl=ENSCAFG00000008977|UniProtKB=J9P7Q4	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF4	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	METJA|EnsemblGenome=MJ_0561|UniProtKB=Q57981	Adenylosuccinate synthetase	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00049	Parkinson disease	P01238	14-3-3	MACMU|Ensembl=ENSMMUG00000013206|UniProtKB=F6XFG9	14-3-3 protein beta/alpha	ISS	1671102	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00052	TGF-beta signaling pathway	P01286	TGFbeta	RAT|RGD=70990|UniProtKB=E9PTU9	Protein Bmp15	TAS	9759503	PubMed	PTHR11848:SF22	BONE MORPHOGENETIC PROTEIN 15
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MOUSE|MGI=MGI=1927343|UniProtKB=Q9Z1M4	Ribosomal protein S6 kinase beta-2	ISS	15116068	PubMed	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00029	Huntington disease	P00797	p53	MOUSE|MGI=MGI=98834|UniProtKB=P02340	Cellular tumor antigen p53	TAS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00034	Integrin signalling pathway	P00924	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00010	B cell activation	P00371	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	RAT|RGD=2736|UniProtKB=P35439	Glutamate receptor ionotropic, NMDA 1	IC	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	PANTR|Ensembl=ENSPTRG00000028339|UniProtKB=H2R4U5	Homeobox protein engrailed-like	ISS	12356903	PubMed	PTHR24341:SF5	HOMEOBOX PROTEIN ENGRAILED-2
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04393	Ras Pathway	P04547	Ras	MONDO|Gene=KRAS|UniProtKB=Q07983	GTPase KRas	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	RAT|RGD=1305515|UniProtKB=F1M0G0	Protein Rgs17	ISS	21240406	PubMed	PTHR10845:SF196	REGULATOR OF G-PROTEIN SIGNALING 17
P00006	Apoptosis signaling pathway	P00273	p53	HUMAN|HGNC=11998|UniProtKB=P04637	Cellular tumor antigen p53	IDA	11313951	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	HUMAN|HGNC=16767|UniProtKB=Q8TCU5	Glutamate receptor ionotropic, NMDA 3A	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00016	Cytoskeletal regulation by Rho GTPase	P00521	Profilin	ARATH|TAIR=AT5G56600|UniProtKB=Q9FE63	Profilin-5	ISS			PTHR11604:SF7	PROFILIN-1-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	IDA	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00034	Integrin signalling pathway	P00941	Integrin alpha	MACMU|Ensembl=ENSMMUG00000016043|UniProtKB=F7GPS1	Uncharacterized protein	ISS	3487386	PubMed	PTHR23220:SF26	INTEGRIN ALPHA-10
P00020	FAS signaling pathway	P00606	Caspase10	PANTR|Ensembl=ENSPTRG00000012800|UniProtKB=H2R694	Uncharacterized protein	ISS	11717445	PubMed	PTHR10454:SF26	CASPASE-10
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	MOUSE|MGI=MGI=87994|UniProtKB=P05064	Fructose-bisphosphate aldolase A	ISS	6086339	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	RCA	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00951	Jnk	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	HUMAN|HGNC=143|UniProtKB=P68032	Actin, alpha cardiac muscle 1	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	P00565	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	BOVIN|Ensembl=ENSBTAG00000018445|UniProtKB=E1BK87	Uncharacterized protein	ISS	14698601	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00004	Alzheimer disease-presenilin pathway	P00163	Erb-B4 C-terminal fragment	MACMU|Ensembl=ENSMMUG00000001674|UniProtKB=F7G3H1	Receptor protein-tyrosine kinase	ISS	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00006	Apoptosis signaling pathway	P00297	NFkappaB	MOUSE|MGI=MGI=1099800|UniProtKB=Q9WTK5	Nuclear factor NF-kappa-B p100 subunit	IDA	12574369	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000012820|UniProtKB=F1MDL3	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05913	Enkephalin release	P05972	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	HUMAN|HGNC=1962|UniProtKB=P17787	Neuronal acetylcholine receptor subunit beta-2	IC	15155845	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06739	MEK1/2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	RCA	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00054	Toll receptor signaling pathway	P01369	MKK1	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00017	DNA replication	P00527	Histones	ORNAN|Ensembl=ENSOANG00000001482|UniProtKB=F7F1M9	Histone H3	ISS	20448842	PubMed	PTHR11426:SF179	HISTONE H3.3
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	TAS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00555	MKK4,7	MONDO|Ensembl=ENSMODG00000008266|UniProtKB=F6Z879	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MACMU|Ensembl=ENSMMUG00000010380|UniProtKB=F7D9M6	Uncharacterized protein	ISS	11744988	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P02738	De novo purine biosynthesis	P02909	GDP reductase	MONDO|Ensembl=ENSMODG00000014763|UniProtKB=F7GGT3	Uncharacterized protein	ISS			PTHR23409:SF20	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00627	ERK1-2	ARATH|TAIR=AT3G45640|UniProtKB=Q39023	Mitogen-activated protein kinase 3	ISS			PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00634	MEKK1-5	BOVIN|Ensembl=ENSBTAG00000009065|UniProtKB=F1MXH6	Uncharacterized protein	ISS	8974401	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00019	Endothelin signaling pathway	P00590	IP3 R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	XENTR|Xenbase=XB-GENE-1011906|UniProtKB=F6XPD5	Uncharacterized protein (Fragment)	ISS			PTHR11824:SF8	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-3
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IDA	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	MONDO|Ensembl=ENSMODG00000015456|UniProtKB=F6S406	Uncharacterized protein	ISS	1768802	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02748	Isoleucine biosynthesis	P02996	Ketol-acid reductoisomerase	AQUAE|EnsemblGenome=aq_1245|UniProtKB=O67289	Ketol-acid reductoisomerase	ISS			PTHR21371:SF1	KETOL-ACID REDUCTOISOMERASE, CHLOROPLASTIC
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	CANLF|Ensembl=ENSCAFG00000028654|UniProtKB=J9P702	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MOUSE|MGI=MGI=1928375|UniProtKB=Q9JM76	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	DANRE|ZFIN=ZDB-GENE-040120-7|UniProtKB=Q7ZWH4	Actin-related protein 2/3 complex subunit 5	ISS	12473693	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00018	EGF receptor signaling pathway	P00558	SOS	CHICK|Ensembl=ENSGALG00000013224|UniProtKB=F1NMA4	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00059	p53 pathway	P04609	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	G06677	Junc	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	RCA	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	MACMU|Ensembl=ENSMMUG00000007653|UniProtKB=F7AI08	Uncharacterized protein	ISS			PTHR10024:SF282	SYNAPTOTAGMIN-5
P04380	Cortocotropin releasing factor receptor signaling pathway	P04451	CRHR1	TAKRU|Ensembl=ENSTRUG00000008096|UniProtKB=H2T6B8	Uncharacterized protein	ISS	11145609	PubMed	PTHR12011:SF175	CORTICOTROPIN-RELEASING FACTOR RECEPTOR 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	8787761	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MONDO|Ensembl=ENSMODG00000012009|UniProtKB=F7AMI2	Uncharacterized protein	ISS	12562507	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P00059	p53 pathway	G04705	p48	HUMAN|HGNC=2718|UniProtKB=Q92466	DNA damage-binding protein 2	IDA	14560002	PubMed	PTHR15169:SF2	DNA DAMAGE-BINDING PROTEIN 2
P00029	Huntington disease	P00790	beta-Tubulin	RAT|RGD=1309427|UniProtKB=Q3KRE8	Tubulin beta-2B chain	TAS	9454836	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PANTR|Ensembl=ENSPTRG00000008769|UniProtKB=H2R9J3	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF681	MYOSIN-4
P00029	Huntington disease	P00775	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12912997	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00010	B cell activation	P00402	Jnk	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01160	IP3 receptor	DROME|FlyBase=FBgn0010051|UniProtKB=P29993	Inositol 1,4,5-trisphosphate receptor	ISS	9065779	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	DANRE|ZFIN=ZDB-GENE-000616-15|UniProtKB=Q9I9E1	Forkhead box protein H1	IGI	8878477	PubMed	PTHR11829:SF191	FORKHEAD BOX PROTEIN H1
P00034	Integrin signalling pathway	P00925	MEK	CHICK|Ensembl=ENSGALG00000004735|UniProtKB=F1NHE1	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	DROME|FlyBase=FBgn0001085|UniProtKB=P18537	Frizzled	TAS	11212302	PubMed	PTHR11309:SF47	FRIZZLED
P00049	Parkinson disease	P01212	p38 MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000021900|UniProtKB=F1MFK1	Uncharacterized protein	ISS	125549	gi	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	RAT|RGD=2869|UniProtKB=P24062	Insulin-like growth factor 1 receptor	ISS	249616	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00034	Integrin signalling pathway	P00942	Fyn	TAKRU|Ensembl=ENSTRUG00000014739|UniProtKB=H2UL58	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00011	Blood coagulation	P00460	FXI	PANTR|Gene=F9|UniProtKB=Q95ND7	Coagulation factor IX	ISS	14270099	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	XENTR|Xenbase=XB-GENE-494028|UniProtKB=F6XHC4	Uncharacterized protein	ISS	10485843	PubMed	PTHR10005:SF15	SKI ONCOGENE
P00010	B cell activation	P00384	p38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	HUMAN|HGNC=1403|UniProtKB=P54284	Voltage-dependent L-type calcium channel subunit beta-3	IC			PTHR11824:SF8	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-3
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	HUMAN|HGNC=9441|UniProtKB=P51817	cAMP-dependent protein kinase catalytic subunit PRKX	IC	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00017	DNA replication	P00527	Histones	STRPU|EnsemblGenome=SPU_003828|UniProtKB=W4XKA2	Histone H3	ISS	12413958	PubMed	PTHR11426:SF20	HISTONE H3-LIKE CENTROMERIC PROTEIN A
P00006	Apoptosis signaling pathway	P00317	Fos	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	DICDI|dictyBase=DDB_G0274455|UniProtKB=Q9U1M8	Myosin-I heavy chain	IC			PTHR13140:SF682	MYOSIN-I HEAVY CHAIN
P00034	Integrin signalling pathway	P00930	Dock180	PANTR|Ensembl=ENSPTRG00000003048|UniProtKB=H2Q2R7	Uncharacterized protein	RCA			PTHR23317:SF79	DEDICATOR OF CYTOKINESIS PROTEIN 1
P00013	Cell cycle	P00480	Proteasome	SCHPO|PomBase=SPAC607.05|UniProtKB=Q9US13	Probable 26S proteasome regulatory subunit rpn9	ISS	21848401	PubMed	PTHR10539:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00590	IP3 R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00006	Apoptosis signaling pathway	P00260	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IDA	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00559	MEK1-2	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IGI	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	RAT|RGD=3188|UniProtKB=Q9QW30	Neurogenic locus notch homolog protein 2	IDA	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00034	Integrin signalling pathway	P00922	Collagen	MONDO|Ensembl=ENSMODG00000003278|UniProtKB=F7EG27	Uncharacterized protein	ISS	10778855	PubMed	PTHR24023:SF42	COLLAGEN ALPHA-1 XI  CHAIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00925	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04393	Ras Pathway	P04541	p90RSK	MOUSE|MGI=MGI=104558|UniProtKB=P18653	Ribosomal protein S6 kinase alpha-1	IDA	12213813	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00021	FGF signaling pathway	P00634	MEKK1-5	PANTR|Ensembl=ENSPTRG00000024326|UniProtKB=H2R231	Uncharacterized protein	ISS	12566458	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00012	Cadherin signaling pathway	P00474	Wnt	CHICK|Ensembl=ENSGALG00000004790|UniProtKB=P49337	Protein Wnt-4	IDA	11266476	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02728	Arginine biosynthesis	P02848	N-acetylglutamate synthase	HUMAN|HGNC=17996|UniProtKB=Q8N159	N-acetylglutamate synthase, mitochondrial	ISS			PTHR23342:SF0	N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01219	SAPK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	NAS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04398	p53 pathway feedback loops 2	G04714	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TAKRU|Ensembl=ENSTRUG00000014318|UniProtKB=H2UI49	Uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	HUMAN|HGNC=1388|UniProtKB=O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	14624853	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P02777	Succinate to proprionate conversion	P03161	Methylmalonyl-CoA mutase	STRCO|Gene=CAC17657|UniProtKB=Q9EWD8	Methylmalonyl CoA mutase	ISS			PTHR43589:SF3	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00586	Gq	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00049	Parkinson disease	P01211	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00398	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00007	Axon guidance mediated by semaphorins	P00341	Rho	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05913	Enkephalin release	P05974	G-Protein (i)	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	MACMU|Ensembl=ENSMMUG00000022009|UniProtKB=F6RBZ7	Cell division control protein 42 homolog isoform 2	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00025	Hedgehog signaling pathway	P00692	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MACMU|Ensembl=ENSMMUG00000000223|UniProtKB=F6XHK8	Uncharacterized protein	ISS	12181435	PubMed	PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P00018	EGF receptor signaling pathway	P00547	PP2A	HUMAN|HGNC=9309|UniProtKB=Q15172	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform	ISS	12110603	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01333	cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P02757	O-antigen biosynthesis	P03049	Glucosamine-1-phosphate acetyltransferase	FUSNN|EnsemblGenome=FN1991|UniProtKB=Q8RHM3	Bifunctional protein GlmU	ISS			PTHR43584:SF3	BIFUNCTIONAL PROTEIN GLMU
P00005	Angiogenesis	P00204	PLD	RAT|RGD=3349|UniProtKB=P70496	Phospholipase D1	ISS	10497874	PubMed	PTHR18896:SF57	PHOSPHOLIPASE D1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	ANOGA|Gene=AgaP_AGAP011360|UniProtKB=Q7Q2V9	AGAP011360-PA (Fragment)	IDA	9388255	PubMed	PTHR11792:SF17	KURTZ ARRESTIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IC	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00036	Interleukin signaling pathway	P00990	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P05918	p38 MAPK pathway	P06034	MKK4	MACMU|Ensembl=ENSMMUG00000019842|UniProtKB=F7FU91	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P02775	Salvage pyrimidine ribonucleotides	P03150	Uridine kinase	ARATH|TAIR=AT5G40870|UniProtKB=Q9FKS0	Uridine kinase-like protein 1, chloroplastic	ISS			PTHR10285:SF70	URIDINE-CYTIDINE KINASE 2
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	HUMAN|HGNC=8528|UniProtKB=P01178	Oxytocin-neurophysin 1	ISS	9756087	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00029	Huntington disease	P00774	Dynein complex	ORNAN|Ensembl=ENSOANG00000003925|UniProtKB=F6UXY7	Uncharacterized protein	ISS	9454836	PubMed	PTHR11886:SF35	DYNEIN LIGHT CHAIN 2, CYTOPLASMIC
P00010	B cell activation	P00380	fos	BOVIN|Ensembl=ENSBTAG00000004322|UniProtKB=O77628	Proto-oncogene c-Fos	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=1954|UniProtKB=P08912	Muscarinic acetylcholine receptor M5	IDA			PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IC	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00056	VEGF signaling pathway	P01411	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00029	Huntington disease	P00790	beta-Tubulin	CHLRE|EnsemblGenome=CHLREDRAFT_129868|UniProtKB=A8IXZ0	Beta tubulin 1	TAS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P02773	S-adenosylmethionine biosynthesis	P03142	Cobalamin-dependent homocysteine transmethylase	FUSNN|EnsemblGenome=FN0163|UniProtKB=Q8RGW4	5-methyltetrahydrofolate--homocysteine methyltransferase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	MACMU|Ensembl=ENSMMUG00000016675|UniProtKB=F6VTB5	Uncharacterized protein	ISS	14698601	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00029	Huntington disease	P00782	alpha-Adaptin	CHICK|Ensembl=ENSGALG00000006799|UniProtKB=E1C866	Uncharacterized protein	ISS	11532990	PubMed	PTHR22780:SF4	AP-2 COMPLEX SUBUNIT ALPHA-2
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	RAT|RGD=3188|UniProtKB=Q9QW30	Neurogenic locus notch homolog protein 2	IDA	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	AQUAE|EnsemblGenome=aq_1290|UniProtKB=O67321	Adenylosuccinate synthetase	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	CANLF|Ensembl=ENSCAFG00000001097|UniProtKB=E2RCX6	Uncharacterized protein	ISS	8163524	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	RCA	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00916	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	3035212	PubMed	PTHR24070:SF385	GTPASE HRAS
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00029	Huntington disease	P00778	NMDA receptor	PANTR|Ensembl=ENSPTRG00000023608|UniProtKB=H2QZZ2	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P05731	GABA-B receptor II signaling	P05754	Ggamma	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00025	Hedgehog signaling pathway	P00697	Sap18	DANRE|ZFIN=ZDB-GENE-040426-1679|UniProtKB=Q6PC41	Sap18 protein	ISS	11960000	PubMed	PTHR13082:SF0	HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IGI	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	RCA	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00029	Huntington disease	P00782	alpha-Adaptin	MOUSE|MGI=MGI=101920|UniProtKB=P17427	AP-2 complex subunit alpha-2	IDA	11532990	PubMed	PTHR22780:SF4	AP-2 COMPLEX SUBUNIT ALPHA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01322	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	RCA	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04651	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00047	PDGF signaling pathway	P01173	STAT	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	ISS	12461178	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00057	Wnt signaling pathway	P01451	Galpha	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	IDA	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	MACMU|Ensembl=ENSMMUG00000022009|UniProtKB=F6RBZ7	Cell division control protein 42 homolog isoform 2	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00053	T cell activation	P01311	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	RCA	10693759	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00059	p53 pathway	G01581	BAX	BOVIN|Ensembl=ENSBTAG00000013340|UniProtKB=O02703	Apoptosis regulator BAX	ISS	14963330	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P02788	Xanthine and guanine salvage pathway	P03249	Guanine deaminase	BOVIN|Ensembl=ENSBTAG00000011545|UniProtKB=F1MLX9	Graves disease carrier protein	ISS			PTHR11271:SF6	GUANINE DEAMINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IC	10644715	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00057	Wnt signaling pathway	P01471	alpha-catenin	TAKRU|Ensembl=ENSTRUG00000002863|UniProtKB=H2S2N9	Uncharacterized protein	ISS	9362521	PubMed	PTHR18914:SF29	CATENIN ALPHA-2
P00049	Parkinson disease	P01236	Casein kinase II	DROME|FlyBase=FBgn0026136|UniProtKB=O96863	Casein kinase II subunit beta'	IDA	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00557	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00510	mDia	MACMU|Ensembl=ENSMMUG00000021964|UniProtKB=F6V4Y9	Uncharacterized protein	ISS			PTHR23213:SF17	PROTEIN DIAPHANOUS HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	HUMAN|HGNC=17780|UniProtKB=Q562R1	Beta-actin-like protein 2	IC	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00023	General transcription regulation	P00658	TBP-associated factors	BOVIN|Ensembl=ENSBTAG00000011339|UniProtKB=A7MAZ4	Transcription initiation factor TFIID subunit 8	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00018	EGF receptor signaling pathway	G01511	SPRY	XENTR|Xenbase=XB-GENE-482101|UniProtKB=Q5Y173	Sprouty2	ISS	21231191	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	SCHPO|PomBase=SPBC106.10|UniProtKB=P40376	cAMP-dependent protein kinase catalytic subunit	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05923	beta-ARR2	CANLF|Ensembl=ENSCAFG00000015905|UniProtKB=E2QUH6	Uncharacterized protein	ISS	11742073	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P02748	Isoleucine biosynthesis	P02994	Branched chain amino acid aminotransferase	METAC|EnsemblGenome=MA_4349|UniProtKB=Q8TI08	Branched chain amino acid aminotransferase	ISS			PTHR42743:SF3	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE-LIKE PROTEIN 1-RELATED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IDA	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00059	p53 pathway	P01486	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MONDO|Gene=KRAS|UniProtKB=Q07983	GTPase KRas	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00048	PI3 kinase pathway	P01182	Ras	DANRE|ZFIN=ZDB-GENE-040808-67|UniProtKB=Q6AZA4	K-ras	ISS	20362513	PubMed	PTHR24070:SF186	GTPASE KRAS
P06664	Gonadotropin-releasing hormone receptor pathway	P06819	SMAD2-4	MOUSE|MGI=MGI=894293|UniProtKB=P97471	Mothers against decapentaplegic homolog 4	RCA	9395284	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00137	Tip60	CANLF|Ensembl=ENSCAFG00000016955|UniProtKB=E2RRZ5	Histone acetyltransferase	ISS			PTHR10615:SF102	HISTONE ACETYLTRANSFERASE KAT7
P00047	PDGF signaling pathway	P01167	Ets	HUMAN|HGNC=3246|UniProtKB=Q9NZC4	ETS homologous factor	ISS	15298723	PubMed	PTHR11849:SF171	ETS HOMOLOGOUS FACTOR
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CAEBR|Gene=CBG23091|UniProtKB=A8Y4Q9	Protein CBR-ACT-2	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00005	Angiogenesis	P00206	Wnt	BOVIN|Ensembl=ENSBTAG00000015364|UniProtKB=E1BEN9	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00011	Blood coagulation	P00406	Fibrinogen	MACMU|Ensembl=ENSMMUG00000021302|UniProtKB=F6UZ87	Uncharacterized protein	ISS	223002	gi	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00057	Wnt signaling pathway	P01432	Beta-Catenin	TAKRU|Ensembl=ENSTRUG00000003520|UniProtKB=H2S791	Uncharacterized protein	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00036	Interleukin signaling pathway	P00970	Interleukin	MACMU|Gene=IL5|UniProtKB=P48093	Interleukin-5	ISS			PTHR45421:SF1	INTERLEUKIN-5
P00006	Apoptosis signaling pathway	P00292	IkappaB	RAT|RGD=3171|UniProtKB=Q63746	NF-kappa-B inhibitor alpha	ISS	10869418	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00057	Wnt signaling pathway	P01430	p53	BOVIN|Ensembl=ENSBTAG00000001069|UniProtKB=P67939	Cellular tumor antigen p53	IDA	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=620420|UniProtKB=Q91XU7	Cadherin-related family member 1	IDA	8120095	PubMed	PTHR44506:SF1	CADHERIN-RELATED FAMILY MEMBER 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=19218|UniProtKB=Q86YW0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1	ISS	10934033	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P04393	Ras Pathway	P04563	Ets	XENTR|Xenbase=XB-GENE-6465484|UniProtKB=B3DM35	LOC100170599 protein	ISS	2205841	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00056	VEGF signaling pathway	P01410	Caspase9	MACMU|Ensembl=ENSMMUG00000018163|UniProtKB=F7FNC1	Caspase	ISS	9390557	PubMed	PTHR10454:SF157	CASPASE-9
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DANRE|ZFIN=ZDB-GENE-030131-55|UniProtKB=Q6XNL8	Actin	IEP	10974003	PubMed	PTHR11937:SF263	ACTIN
P06959	CCKR signaling map	P07178	CaN	HUMAN|HGNC=9314|UniProtKB=Q08209	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	RCA		PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01444	Wnt	CHICK|Ensembl=ENSGALG00000014235|UniProtKB=Q3L254	Protein Wnt-7b	ISS	11266476	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00046	Oxidative stress response	P01129	JNK1/2	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00049	Parkinson disease	P01230	Src kinase	BOVIN|Ensembl=ENSBTAG00000011851|UniProtKB=A0JNB0	Tyrosine-protein kinase Fyn	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00049	Parkinson disease	P01219	SAPK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	BOVIN|Ensembl=ENSBTAG00000016138|UniProtKB=P01217	Glycoprotein hormones alpha chain	ISS	1099091	PubMed	PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P06664	Gonadotropin-releasing hormone receptor pathway	P06701	TCF	MOUSE|MGI=MGI=1202876|UniProtKB=Q9Z1J1	Transcription factor 7-like 1	RCA	9118222	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00021	FGF signaling pathway	P00640	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MOUSE|MGI=MGI=1915021|UniProtKB=Q9CPW4	Actin-related protein 2/3 complex subunit 5	ISS	12932731	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00029	Huntington disease	P00796	Kainate receptor	MACMU|Ensembl=ENSMMUG00000009679|UniProtKB=F6YBQ8	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00057	Wnt signaling pathway	P01443	Phospholipase C	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05916	Opioid prodynorphin pathway	P06002	G-protein	XENTR|Xenbase=XB-GENE-963560|UniProtKB=Q0VFC4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00053	T cell activation	P01300	ERK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00260	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MACMU|Ensembl=ENSMMUG00000016675|UniProtKB=F6VTB5	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00029	Huntington disease	G01535	PIG3	GLOVI|Gene=BAC89890|UniProtKB=Q7NJ83	Gll1949 protein	TAS			PTHR44054:SF3	SUBFAMILY NOT NAMED
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=99551|UniProtKB=Q9WTR5	Cadherin-13	IDA	8120095	PubMed	PTHR24027:SF80	CADHERIN-13
P06664	Gonadotropin-releasing hormone receptor pathway	P06813	EIF2AK3	MOUSE|MGI=MGI=1341830|UniProtKB=Q9Z2B5	Eukaryotic translation initiation factor 2-alpha kinase 3	RCA			PTHR11042:SF108	EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00018	EGF receptor signaling pathway	P00545	JNK1-3	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IGI	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	HUMAN|HGNC=4594|UniProtKB=Q14416	Metabotropic glutamate receptor 2	ISS	9407094	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P04393	Ras Pathway	P04560	AP1	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00018	EGF receptor signaling pathway	P00564	Rac	DANRE|ZFIN=ZDB-GENE-030131-8877|UniProtKB=Q803F2	Ras homolog gene family, member Gb	ISS			PTHR24072:SF158	RHO-RELATED GTP-BINDING PROTEIN RHOG
P00035	Interferon-gamma signaling pathway	P00957	IFNGR2	MACMU|Ensembl=ENSMMUG00000005508|UniProtKB=F7FLL3	Uncharacterized protein	ISS	14525967	PubMed	PTHR20859:SF46	INTERFERON GAMMA RECEPTOR 2
P00059	p53 pathway	P04630	PP2A	MACMU|Ensembl=ENSMMUG00000013047|UniProtKB=F7H808	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CHICK|Ensembl=ENSGALG00000009621|UniProtKB=P60706	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00006	Apoptosis signaling pathway	P00274	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	ISS	14744463	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04393	Ras Pathway	P04552	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IDA	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00012	Cadherin signaling pathway	P00474	Wnt	DANRE|ZFIN=ZDB-GENE-990603-12|UniProtKB=O73864	Protein Wnt-11	IDA	11266476	PubMed	PTHR12027:SF34	PROTEIN WNT
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00019	Endothelin signaling pathway	P00570	PKA	STRPU|EnsemblGenome=SPU_018419|UniProtKB=W4YRI6	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00034	Integrin signalling pathway	P00932	FAK	CANLF|Ensembl=ENSCAFG00000008670|UniProtKB=E2QTG4	Uncharacterized protein	ISS	12640026	PubMed	PTHR24418:SF94	PROTEIN-TYROSINE KINASE 2-BETA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4388|UniProtKB=P38405	Guanine nucleotide-binding protein G(olf) subunit alpha	IC	14765990	PubMed	PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00948	Rho	XENTR|Xenbase=XB-GENE-489222|UniProtKB=Q28GJ8	Ras homolog gene family, member A	ISS	15668138	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00053	T cell activation	P01312	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IDA	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MOUSE|MGI=MGI=95815|UniProtKB=P39087	Glutamate receptor ionotropic, kainate 2	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00019	Endothelin signaling pathway	P00578	eNOS	MONDO|Ensembl=ENSMODG00000003903|UniProtKB=F6S3S1	Nitric oxide synthase	ISS	9837777	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	XENTR|Xenbase=XB-GENE-490883|UniProtKB=Q6NVA9	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00010	B cell activation	P00371	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	TAS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00047	PDGF signaling pathway	P01160	IP3 receptor	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00036	Interleukin signaling pathway	P00974	Receptor subunit beta	HUMAN|HGNC=6027|UniProtKB=P25025	C-X-C chemokine receptor type 2	IC	10741397	PubMed	PTHR10489:SF689	C-X-C CHEMOKINE RECEPTOR TYPE 2
P00021	FGF signaling pathway	P00647	SHP2	BOVIN|Ensembl=ENSBTAG00000002048|UniProtKB=F1N339	Tyrosine-protein phosphatase non-receptor type	ISS	8096088	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00045	Notch signaling pathway	P01114	Ntm	RAT|RGD=3187|UniProtKB=Q07008	Neurogenic locus notch homolog protein 1	IEP	1764995	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000013529|UniProtKB=F6Z6U0	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF323	CADHERIN-19
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	2372396	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00632	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01189	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	TAS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00973	PKB	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P06959	CCKR signaling map	P07174	Pro CCK @ TGN	HUMAN|HGNC=1569|UniProtKB=P06307	Cholecystokinin	RCA	12479974	PubMed	PTHR10786:SF0	CHOLECYSTOKININ
P00034	Integrin signalling pathway	P00920	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	XENTR|Xenbase=XB-GENE-491618|UniProtKB=Q6P378	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00018	EGF receptor signaling pathway	P00565	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	10395542	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00023	General transcription regulation	P00668	TFIIB	HUMAN|HGNC=11551|UniProtKB=Q92994	Transcription factor IIIB 90 kDa subunit	ISS	180660	OMIM	PTHR11618:SF4	TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	14744463	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	RAT|RGD=1305489|UniProtKB=G3V9U0	Acyl-CoA synthetase short-chain family member 2 (Predicted)	ISS			PTHR24095:SF126	ACETYL-COENZYME A SYNTHETASE, CYTOPLASMIC
P00019	Endothelin signaling pathway	P00583	cPLA2	BOVIN|Ensembl=ENSBTAG00000013298|UniProtKB=A4IFJ5	Cytosolic phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00006	Apoptosis signaling pathway	P00318	PKCs	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04393	Ras Pathway	P04570	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00981	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	MOUSE|MGI=MGI=3584516|UniProtKB=E9Q1T6	Protein Lrp3	ISS	11907044	PubMed	PTHR44062:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 3
P00036	Interleukin signaling pathway	P00983	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	IC	10395542	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00048	PI3 kinase pathway	P01185	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00021	FGF signaling pathway	P00624	14-3-3	MONDO|Ensembl=ENSMODG00000009856|UniProtKB=F6WA79	Uncharacterized protein	ISS	12480176	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00018	EGF receptor signaling pathway	P00551	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	CAEEL|WormBase=WBGene00006773|UniProtKB=O02482	Transcription factor unc-37	IDA	9783586	PubMed	PTHR10814:SF26	PROTEIN GROUCHO
P06664	Gonadotropin-releasing hormone receptor pathway	P06798	PKCe/theta	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9441|UniProtKB=P51817	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00060	Ubiquitin proteasome pathway	P01491	E2	MACMU|Ensembl=ENSMMUG00000016641|UniProtKB=F6TV67	Ubiquitin-conjugating enzyme E2 B	ISS			PTHR43898:SF6	UBIQUITIN-CONJUGATING ENZYME E2 B
P05918	p38 MAPK pathway	P06025	SRF	MONDO|Ensembl=ENSMODG00000018981|UniProtKB=F7FP88	Uncharacterized protein	ISS	15647354	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=94927|UniProtKB=Q8BLD9	D(1B) dopamine receptor	ISS			PTHR43893:SF8	D 1B  DOPAMINE RECEPTOR
P02723	Adenine and hypoxanthine salvage pathway	P02811	Adenosine deaminase	MOUSE|MGI=MGI=1923144|UniProtKB=Q80SY6	Adenosine deaminase-like protein	ISS			PTHR11409:SF42	ADENOSINE DEAMINASE-LIKE PROTEIN
P00057	Wnt signaling pathway	P01435	SWI/SNF	MACMU|Ensembl=ENSMMUG00000006531|UniProtKB=F7HTX9	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 isoform a	ISS	11532957	PubMed	PTHR13844:SF1	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D MEMBER 1
P00012	Cadherin signaling pathway	P00470	F-actin	CAEEL|WormBase=WBGene00000066|UniProtKB=P10986	Actin-4	IC	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	CANLF|Ensembl=ENSCAFG00000010476|UniProtKB=F1PS94	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IC	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00057	Wnt signaling pathway	P01448	CBP	ARATH|TAIR=AT1G55970|UniProtKB=Q9LG11	Histone acetyltransferase HAC4	IDA	8413673	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00010	B cell activation	P00401	jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	3136397	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P06959	CCKR signaling map	P07103	PRKD1	HUMAN|HGNC=9407|UniProtKB=Q15139	Serine/threonine-protein kinase D1	RCA	10636921	PubMed	PTHR22968:SF9	SERINE/THREONINE-PROTEIN KINASE D1
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00897	SHIP2	MOUSE|MGI=MGI=1333787|UniProtKB=Q6P549	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	ISS	10610720	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00005	Angiogenesis	P00180	Dok-R	RAT|RGD=1309499|UniProtKB=Q4QQV2	Docking protein 1	ISS			PTHR21258:SF46	DOCKING PROTEIN 1
P00036	Interleukin signaling pathway	P00976	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00038	JAK/STAT signaling pathway	P01027	STAT	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00059	p53 pathway	P01486	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00474	Wnt	BRAFL|Gene=BRAFLDRAFT_56711|UniProtKB=C3XPR5	Protein Wnt	IDA	11266476	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00566	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MOUSE|MGI=MGI=87904|UniProtKB=P60710	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MACMU|Ensembl=ENSMMUG00000002263|UniProtKB=F6VEE0	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00010	B cell activation	P00380	fos	BOVIN|Ensembl=ENSBTAG00000004322|UniProtKB=O77628	Proto-oncogene c-Fos	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00021	FGF signaling pathway	P00636	FGFR1-4	PANTR|Ensembl=ENSPTRG00000003003|UniProtKB=H2Q2P3	Fibroblast growth factor receptor	ISS	14507786	PubMed	PTHR24416:SF130	FIBROBLAST GROWTH FACTOR RECEPTOR 2
P00012	Cadherin signaling pathway	P00462	Casein kinase II	PANTR|Ensembl=ENSPTRG00000017974|UniProtKB=H2QSN4	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00053	T cell activation	P01322	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000005858|UniProtKB=H2Q7J6	Uncharacterized protein	ISS			PTHR24247:SF30	5-HYDROXYTRYPTAMINE RECEPTOR 2A
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P02723	Adenine and hypoxanthine salvage pathway	P02811	Adenosine deaminase	CAEEL|WormBase=WBGene00016630|UniProtKB=Q18599	ACEtyl-CoA Regulator	ISS			PTHR21432:SF19	ACETYL-COA REGULATOR
P00015	Circadian clock system	P00501	Clock	DANRE|ZFIN=ZDB-GENE-990630-14|UniProtKB=Q5RIV1	Uncharacterized protein	ISS			PTHR23042:SF2	CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT
P00049	Parkinson disease	P01242	Casein kinase I	BOVIN|Ensembl=ENSBTAG00000016797|UniProtKB=A7MB90	CSNK1G2 protein	ISS	10617630	PubMed	PTHR11909:SF157	CASEIN KINASE I ISOFORM GAMMA-2
P00013	Cell cycle	P00480	Proteasome	SCHPO|PomBase=SPAC23G3.11|UniProtKB=Q9P7S2	Probable 26S proteasome regulatory subunit rpn6	ISS	21848401	PubMed	PTHR10678:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00054	Toll receptor signaling pathway	P01356	ERK2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04570	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_188187|UniProtKB=E9GJ31	Guanine nucleotide binding protein, q polypeptide	ISS	8457205	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04396	Vitamin D metabolism and pathway	P04607	FDX	DROME|FlyBase=FBgn0035529|UniProtKB=Q8SZA8	Ferredoxin 2	IDA	2969697	PubMed	PTHR23426:SF25	FERREDOXIN 2
P00057	Wnt signaling pathway	P01447	Dishevelled	MOUSE|MGI=MGI=94941|UniProtKB=P51141	Segment polarity protein dishevelled homolog DVL-1	ISS	11212302	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P00029	Huntington disease	P00788	Calpain	MOUSE|MGI=MGI=1920897|UniProtKB=Q9D805	Calpain-9	IDA	11675509	PubMed	PTHR10183:SF385	CALPAIN-9
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	CANLF|Ensembl=ENSCAFG00000010476|UniProtKB=F1PS94	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00047	PDGF signaling pathway	P01142	p90RSK	MACMU|Ensembl=ENSMMUG00000020532|UniProtKB=F7D8E6	Ribosomal protein S6 kinase	ISS	15632195	PubMed	PTHR24351:SF98	RIBOSOMAL PROTEIN S6 KINASE ALPHA-6
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	10188796	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00021	FGF signaling pathway	P00645	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	15470041	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00053	T cell activation	P01312	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00022	General transcription by RNA polymerase I	P00657	TBP	ANOGA|EnsemblGenome=AGAP010958|UniProtKB=Q7PFI3	AGAP010958-PA	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00865	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	8264585	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00048	PI3 kinase pathway	P01181	GSK3	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02751	Lysine biosynthesis	P03007	Diaminopimelate decarboxylase	MYCTU|EnsemblGenome=Rv1293|UniProtKB=P9WIU7	Diaminopimelate decarboxylase	ISS			PTHR43727:SF2	DIAMINOPIMELATE DECARBOXYLASE 1, CHLOROPLASTIC-RELATED
P00059	p53 pathway	P04609	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00006	Apoptosis signaling pathway	P00310	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	IDA	129387	gi	PTHR10048:SF14	PI-3 KINASE
P00011	Blood coagulation	P00410	GP IIb	MACMU|Ensembl=ENSMMUG00000012659|UniProtKB=F7E7I7	Uncharacterized protein	ISS	3487386	PubMed	PTHR23220:SF73	INTEGRIN ALPHA-IIB
P02756	N-acetylglucosamine metabolism	P03036	N-acetylglucosamine-6-phosphate deacetylase	RAT|RGD=1304601|UniProtKB=Q5BJY6	N-acetylglucosamine-6-phosphate deacetylase	ISS			PTHR11113:SF14	N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00053	T cell activation	P01331	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00049	Parkinson disease	P01211	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01444	Wnt	MACMU|Ensembl=ENSMMUG00000000180|UniProtKB=F7HJM7	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	IC	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00053	T cell activation	P01300	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02723	Adenine and hypoxanthine salvage pathway	P02810	Adenine phosphoribosyl transferase	THEMA|EnsemblGenome=TM_1384|UniProtKB=Q9X1A4	Adenine phosphoribosyltransferase	ISS			PTHR32315:SF3	ADENINE PHOSPHORIBOSYLTRANSFERASE
P00053	T cell activation	P01305	Calmodulin	MOUSE|MGI=MGI=103249|UniProtKB=P62204	Calmodulin	ISS	7514101	PubMed	PTHR23050:SF311	CALMODULIN
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	DANRE|ZFIN=ZDB-GENE-000330-9|UniProtKB=Q90ZE4	Presenilin-2	IDA	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00025	Hedgehog signaling pathway	P00692	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04393	Ras Pathway	P04570	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g161273|UniProtKB=A7RPJ6	Predicted protein	ISS	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00029	Huntington disease	P00810	GAPDH	ARATH|TAIR=AT1G13440|UniProtKB=Q9FX54	Glyceraldehyde-3-phosphate dehydrogenase GAPC2, cytosolic	ISS			PTHR10836:SF63	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE GAPC2, CYTOSOLIC
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	MACMU|Ensembl=ENSMMUG00000012305|UniProtKB=F7DLC9	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00048	PI3 kinase pathway	P01189	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	HUMAN|HGNC=4597|UniProtKB=P41594	Metabotropic glutamate receptor 5	ISS	12488551	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00006	Apoptosis signaling pathway	P00303	c-Jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00046	Oxidative stress response	P01129	JNK1/2	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	TAS	10851062	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	PANTR|Ensembl=ENSPTRG00000008769|UniProtKB=H2R9J3	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF681	MYOSIN-4
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	CAEEL|WormBase=WBGene00001615|UniProtKB=Q17697	GLutamate Receptor family (AMPA)	ISS	12941441	PubMed	PTHR18966:SF352	GLUTAMATE RECEPTOR FAMILY  AMPA
P00010	B cell activation	P00375	Calmodulin	TETTS|EnsemblGenome=TTHERM_00630500|UniProtKB=Q241P0	Calmodulin 1	ISS			PTHR23050:SF245	AT16150P-RELATED
P00053	T cell activation	P01324	rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	21071228	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00029	Huntington disease	P00807	Actin	CHICK|Ensembl=ENSGALG00000014620|UniProtKB=F1N8P3	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00050	Plasminogen activating cascade	P01250	MMP-13	MOUSE|MGI=MGI=1340026|UniProtKB=P33435	Collagenase 3	ISS	1383028	PubMed	PTHR10201:SF165	COLLAGENASE 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00010	B cell activation	P00391	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00005	Angiogenesis	P00223	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00550	Grb2	CAEEL|WormBase=WBGene00004774|UniProtKB=P29355	Sex muscle abnormal protein 5	IGI	4504111	gi	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	DROME|FlyBase=FBgn0019947|UniProtKB=O02194	Presenilin homolog	IDA	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BOVIN|Ensembl=ENSBTAG00000020221|UniProtKB=E1BDG5	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	MOUSE|MGI=MGI=109482|UniProtKB=P97445	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	15699344	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P04398	p53 pathway feedback loops 2	P04665	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	RAT|RGD=621348|UniProtKB=Q9QXQ5	Protein Wnt-4	TAS	8717036	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P02728	Arginine biosynthesis	P02840	Argininosuccinate synthase	STRCO|EnsemblGenome=CAC01534|UniProtKB=P24532	Argininosuccinate synthase	ISS			PTHR11587:SF2	ARGININOSUCCINATE SYNTHASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00049	Parkinson disease	P01208	Hsp70	IXOSC|EnsemblGenome=ISCW020763|UniProtKB=B7PXP4	Hsp70, putative (Fragment)	ISS	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P00025	Hedgehog signaling pathway	P00682	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00053	T cell activation	P01322	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00807	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g242065|UniProtKB=A7S0V7	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04395	Vasopressin synthesis	P04594	Neurophysin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00034	Integrin signalling pathway	P00936	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	IPI	1171954	gi	PTHR10048:SF14	PI-3 KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	CHICK|Ensembl=ENSGALG00000007871|UniProtKB=F1NL65	Uncharacterized protein	IC	96032356	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P04397	p53 pathway by glucose deprivation	P04641	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	RAT|RGD=2735|UniProtKB=Q63273	Glutamate receptor ionotropic, kainate 5	ISS	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	XENTR|Xenbase=XB-GENE-960013|UniProtKB=F6U002	Uncharacterized protein	ISS			PTHR42884:SF13	NEUROENDOCRINE CONVERTASE 2
P00021	FGF signaling pathway	P00630	RKIP	MOUSE|MGI=MGI=1923650|UniProtKB=Q8VIN1	Phosphatidylethanolamine-binding protein 2	IGI			PTHR11362:SF8	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 2
P00029	Huntington disease	P00777	CBP	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	IDA	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00018	EGF receptor signaling pathway	P00552	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IGI	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01151	PKB	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00371	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	METAC|EnsemblGenome=MA_3382|UniProtKB=Q8TKM1	Glutamate-ammonia ligase	ISS			PTHR43407:SF1	LENGSIN
P06664	Gonadotropin-releasing hormone receptor pathway	P06847	JNK1/2	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	RCA	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00048	PI3 kinase pathway	P01199	Galpha	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00059	p53 pathway	P04630	PP2A	CHICK|Ensembl=ENSGALG00000010273|UniProtKB=P48463	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01451	Galpha	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01192	p110	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00624	14-3-3	CHICK|Ensembl=ENSGALG00000006743|UniProtKB=Q5ZKJ2	Uncharacterized protein	ISS	6756037	gi	PTHR18860:SF16	14-3-3 PROTEIN ETA
P05913	Enkephalin release	P05974	G-Protein (i)	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00021	FGF signaling pathway	P00624	14-3-3	DANRE|ZFIN=ZDB-GENE-011115-1|UniProtKB=Q6PC29	14-3-3 protein gamma-1	ISS	22165492	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00052	TGF-beta signaling pathway	P01286	TGFbeta	DANRE|ZFIN=ZDB-GENE-990630-11|UniProtKB=F1QWZ9	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF7	SIGNALING MOLECULE LEFTY1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00029	Huntington disease	G01535	PIG3	HUMAN|HGNC=29315|UniProtKB=Q9HCJ6	Synaptic vesicle membrane protein VAT-1 homolog-like	TAS	12932731	PubMed	PTHR44054:SF2	SYNAPTIC VESICLE MEMBRANE PROTEIN VAT-1 HOMOLOG-LIKE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00047	PDGF signaling pathway	P01142	p90RSK	CANLF|Ensembl=ENSCAFG00000013171|UniProtKB=E2RP04	Uncharacterized protein	ISS	6755374	gi	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P06664	Gonadotropin-releasing hormone receptor pathway	P06811	SRF	MOUSE|MGI=MGI=106658|UniProtKB=Q9JM73	Serum response factor	RCA	15647354	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00012	Cadherin signaling pathway	P00465	TCF/LEF	DANRE|ZFIN=ZDB-GENE-980605-30|UniProtKB=Q9YHE8	Transcription factor 7-like 1-A	ISS	12356903	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06743	Cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	RCA	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00059	p53 pathway	P04630	PP2A	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000003236|UniProtKB=F7DNS6	Uncharacterized protein	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00036	Interleukin signaling pathway	P00977	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ARATH|TAIR=AT1G60490|UniProtKB=P42339	Phosphatidylinositol 3-kinase VPS34	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00021	FGF signaling pathway	P00629	PP2A	CHICK|Ensembl=ENSGALG00000000235|UniProtKB=F1NBJ2	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B	ISS	11956189	PubMed	PTHR11871:SF2	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00983	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00047	PDGF signaling pathway	P01145	c-fos	BOVIN|Ensembl=ENSBTAG00000004322|UniProtKB=O77628	Proto-oncogene c-Fos	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	CHICK|Ensembl=ENSGALG00000000681|UniProtKB=E1C3P6	Uncharacterized protein	ISS	14580336	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P05731	GABA-B receptor II signaling	P05754	Ggamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00059	p53 pathway	P04610	Cyclin E	MOUSE|MGI=MGI=88316|UniProtKB=Q61457	G1/S-specific cyclin-E1	ISS	15705141	gi	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	8687404	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00012	Cadherin signaling pathway	P00470	F-actin	DICDI|dictyBase=DDB_G0289811|UniProtKB=Q54GX7	Actin-10	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	P01437	TCF	CANLF|Ensembl=ENSCAFG00000011252|UniProtKB=F1Q334	Uncharacterized protein	ISS	11266476	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	HUMAN|HGNC=4600|UniProtKB=O00222	Metabotropic glutamate receptor 8	IC	12351712	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00048	PI3 kinase pathway	P01182	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	18021322	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	RAT|RGD=71014|UniProtKB=Q04400	Adenylate cyclase type 5	IGI	2491850	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00006	Apoptosis signaling pathway	P00260	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00944	Actin	HUMAN|HGNC=17780|UniProtKB=Q562R1	Beta-actin-like protein 2	IPI	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CANLF|Ensembl=ENSCAFG00000018564|UniProtKB=E2RHU1	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IDA	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DICPU|Gene=DICPUDRAFT_93216|UniProtKB=F1A421	Guanine nucleotide-binding protein subunit beta	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00010	B cell activation	P00381	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00078	Alpha1A/1B/1C	HUMAN|HGNC=283|UniProtKB=P18825	Alpha-2C adrenergic receptor	RCA			PTHR24248:SF25	ALPHA-2C ADRENERGIC RECEPTOR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Gene=DRD2|UniProtKB=P20288	D(2) dopamine receptor	IDA	1319557	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00562	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	TAS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ASHGO|EnsemblGenome=AGOS_ABR222W|UniProtKB=Q75D00	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	DROME|FlyBase=FBgn0001991|UniProtKB=Q24270	Voltage-dependent calcium channel type D subunit alpha-1	ISS	15621031	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	METAC|EnsemblGenome=MA_2143|UniProtKB=Q8TNY4	Carbamoyl-phosphate synthase large chain	ISS			PTHR11405:SF5	CAD PROTEIN
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IDA	10669416	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00632	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MONDO|Ensembl=ENSMODG00000007194|UniProtKB=F6X9N6	Actin-related protein 2/3 complex subunit 5	ISS	12932731	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00034	Integrin signalling pathway	P00916	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00036	Interleukin signaling pathway	P00977	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P05912	Dopamine receptor mediated signaling pathway	P05970	TH	HUMAN|HGNC=11782|UniProtKB=P07101	Tyrosine 3-monooxygenase	ISS	191290	OMIM	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MONDO|Ensembl=ENSMODG00000013970|UniProtKB=F6R6X5	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	BOVIN|Ensembl=ENSBTAG00000019988|UniProtKB=F1N2V3	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P00005	Angiogenesis	P00242	TCF	HUMAN|HGNC=11641|UniProtKB=Q9NQB0	Transcription factor 7-like 2	IDA	11266476	PubMed	PTHR10373:SF32	TRANSCRIPTION FACTOR 7-LIKE 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00046	Oxidative stress response	P01129	JNK1/2	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	TAS	10514528	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00020	FAS signaling pathway	P00605	Pro-Caspase7	MACMU|Ensembl=ENSMMUG00000001217|UniProtKB=F7DA15	Uncharacterized protein	ISS	14583630	PubMed	PTHR10454:SF31	CASPASE-7
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	BOVIN|Ensembl=ENSBTAG00000013843|UniProtKB=F1MIW7	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF66	SERINE/THREONINE-PROTEIN KINASE RECEPTOR R3
P00059	p53 pathway	P04623	CBP	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04553	PAK	MOUSE|MGI=MGI=1339656|UniProtKB=Q61036	Serine/threonine-protein kinase PAK 3	IDA	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00054	Toll receptor signaling pathway	P01360	IKKbeta	PANTR|Ensembl=ENSPTRG00000020202|UniProtKB=H2QW34	Uncharacterized protein	ISS	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00053	T cell activation	P01306	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	IC	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00078	Alpha1A/1B/1C	BOVIN|Gene=ADRA1A|UniProtKB=P18130	Alpha-1A adrenergic receptor	IC	11781138	PubMed	PTHR24248:SF16	ALPHA-1A ADRENERGIC RECEPTOR
P00055	Transcription regulation by bZIP transcription factor	P01390	TFIIA complex	ORYSJ|EnsemblGenome=OS05G0107700|UniProtKB=Q0DLD3	Transcription initiation factor IIA subunit 2	ISS			PTHR10966:SF0	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IGI	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00570	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	ISS	2372396	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	BOVIN|Ensembl=ENSBTAG00000018445|UniProtKB=E1BK87	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00012	Cadherin signaling pathway	P00471	Cadherin	BOVIN|Ensembl=ENSBTAG00000012518|UniProtKB=F6Q0C0	Uncharacterized protein	ISS	8120095	PubMed	PTHR43912:SF3	PROTOCADHERIN-1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00052	TGF-beta signaling pathway	P01275	P38	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01206	14-3-3	ANOGA|EnsemblGenome=AGAP007643|UniProtKB=A0NBC2	AGAP007643-PA	ISS	10407019	PubMed	PTHR18860:SF13	14-3-3 PROTEIN ZETA
P00010	B cell activation	P00397	IKK	RAT|RGD=621375|UniProtKB=Q9QY78	Inhibitor of nuclear factor kappa-B kinase subunit beta	IGI	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00034	Integrin signalling pathway	P00922	Collagen	RAT|RGD=70920|UniProtKB=Q9JI03	Collagen alpha-1(V) chain	IDA	10778855	PubMed	PTHR24023:SF387	COLLAGEN ALPHA-1 V  CHAIN
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DROME|FlyBase=FBgn0011743|UniProtKB=P45891	Actin-like protein 53D	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00021	FGF signaling pathway	P00624	14-3-3	MOUSE|MGI=MGI=109484|UniProtKB=P63101	14-3-3 protein zeta/delta	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000022319|UniProtKB=F6XDA0	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	XENTR|Xenbase=XB-GENE-481916|UniProtKB=F6YF14	Presenilin	ISS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IDA	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9060|UniProtKB=P51178	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	TAS			PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00034	Integrin signalling pathway	P00912	Arp2/3	MOUSE|MGI=MGI=1343142|UniProtKB=Q9WV32	Actin-related protein 2/3 complex subunit 1B	IPI	9618202	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	HUMAN|HGNC=6003|UniProtKB=Q9UHF4	Interleukin-20 receptor subunit alpha	IC	11163236	PubMed	PTHR20859:SF21	INTERLEUKIN-20 RECEPTOR SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IDA	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P05731	GABA-B receptor II signaling	P05752	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01208	Hsp70	MONDO|Ensembl=ENSMODG00000023945|UniProtKB=F6V652	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF216	HEAT SHOCK-RELATED 70 KDA PROTEIN 2
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	NEUCR|EnsemblGenome=EFNCRG00000000159|UniProtKB=F5HH30	Guanine nucleotide-binding protein beta subunit	IC	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00010	B cell activation	P00384	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P02771	Pyrimidine Metabolism	P03124	Methylmalonate Semialdehyde Dehydrogenase	MONDO|Ensembl=ENSMODG00000006429|UniProtKB=F7EZH4	Uncharacterized protein	ISS	2708830	gi	PTHR43866:SF3	METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE  ACYLATING , MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	DICPU|Gene=DICPUDRAFT_168754|UniProtKB=F0ZQR3	Rac1B, RHO family GTPase	ISS			PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	HUMAN|HGNC=4572|UniProtKB=P42262	Glutamate receptor 2	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	SCLS1|Gene=SS1G_08733|UniProtKB=A7ETS6	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00005	Angiogenesis	P00189	Fzd	BOVIN|Ensembl=ENSBTAG00000035084|UniProtKB=F1MLG5	Uncharacterized protein	ISS	12549854	PubMed	PTHR11309:SF22	FRIZZLED-3
P00019	Endothelin signaling pathway	P00590	IP3 R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00018	EGF receptor signaling pathway	P00559	MEK1-2	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00059	p53 pathway	G04702	p53	MACMU|Ensembl=ENSMMUG00000016569|UniProtKB=F6VXE7	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00020	FAS signaling pathway	P00620	CytochromeC	HUMAN|HGNC=2579|UniProtKB=P08574	Cytochrome c1, heme protein, mitochondrial	ISS	9027315	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00005	Angiogenesis	P00238	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	PANTR|Gene=DRD2|UniProtKB=P60026	D(2) dopamine receptor	ISS	11248120	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	BOVIN|Ensembl=ENSBTAG00000006295|UniProtKB=P01223	Thyrotropin subunit beta	ISS	3017658	PubMed	PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P05731	GABA-B receptor II signaling	P05753	Ca channel	MOUSE|MGI=MGI=88296|UniProtKB=O55017	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	14507926	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P06212	DPP-SCW signaling pathway	P06270	PUT	DROME|Gene=Dmel_CG7904|UniProtKB=A0A0B4KG59	Serine/threonine-protein kinase receptor	IEA	9395284	PubMed	PTHR23255:SF70	SERINE/THREONINE-PROTEIN KINASE RECEPTOR
P00047	PDGF signaling pathway	P01162	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00038	JAK/STAT signaling pathway	P01030	SOCS	MOUSE|MGI=MGI=1354910|UniProtKB=O35716	Suppressor of cytokine signaling 1	ISS			PTHR44621:SF2	SUPPRESSOR OF CYTOKINE SIGNALING 1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P02783	Tryptophan biosynthesis	P03210	Indole-3-glycerol phosphate synthase	RHOBA|EnsemblGenome=RB10114|UniProtKB=Q7UKJ7	Indole-3-glycerol phosphate synthase	ISS			PTHR22854:SF2	TRYPTOPHAN BIOSYNTHESIS PROTEIN TRPCF
P00059	p53 pathway	P04609	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05730	Endogenous cannabinoid signaling	P05751	Galpha	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05917	Opioid proopiomelanocortin pathway	P06004	Mu or Delta receptor	MOUSE|MGI=MGI=97441|UniProtKB=P42866	Mu-type opioid receptor	ISS	11259498	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00005	Angiogenesis	P00256	PLC-gamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00054	Toll receptor signaling pathway	P01365	TAB1	PANTR|Ensembl=ENSPTRG00000014395|UniProtKB=H2QLQ4	Uncharacterized protein	ISS	8638164	PubMed	PTHR13832:SF533	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	ORNAN|Ensembl=ENSOANG00000005917|UniProtKB=F6QM53	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00029	Huntington disease	P00764	MLK-2	DROME|FlyBase=FBgn0030018|UniProtKB=Q95UN8	Mitogen-activated protein kinase kinase kinase	IDA			PTHR43997:SF4	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CANLF|Ensembl=ENSCAFG00000002046|UniProtKB=E2RBE7	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00048	PI3 kinase pathway	P01192	p110	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	RAT|RGD=3187|UniProtKB=Q07008	Neurogenic locus notch homolog protein 1	IDA	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04397	p53 pathway by glucose deprivation	P04636	S6K	CANLF|Ensembl=ENSCAFG00000017679|UniProtKB=E2RMD8	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00030	Hypoxia response via HIF activation	P00819	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000003399|UniProtKB=H2Q383	Phosphoinositide-3-kinase, class 2, alpha polypeptide	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	CHICK|Ensembl=ENSGALG00000008534|UniProtKB=E1BSD8	Uncharacterized protein	ISS	606023	OMIM	PTHR10917:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3
P02746	Heme biosynthesis	P02975	Uroporphyrinogen decarboxylase	XENTR|Xenbase=XB-GENE-948493|UniProtKB=Q28J36	Uroporphyrinogen decarboxylase	ISS			PTHR21091:SF2	UROPORPHYRINOGEN DECARBOXYLASE
P00034	Integrin signalling pathway	P00906	Rap1	XENTR|Xenbase=XB-GENE-5801166|UniProtKB=F6ZE26	Uncharacterized protein	ISS	1904317	PubMed	PTHR24070:SF382	RAS-RELATED PROTEIN RAP-1B
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	RAT|RGD=620676|UniProtKB=F1M7N7	Ribosomal protein S6 kinase	ISS	15526037	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=2136735|UniProtKB=Q91Y00	Protein Pcdhb2	IDA	8120095	PubMed	PTHR24028:SF77	PROTOCADHERIN BETA-2
P00059	p53 pathway	P01486	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TRYB2|Gene=Tb09.211.0620|UniProtKB=Q38E94	Actin A	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00053	T cell activation	P01315	Calcineurin	HUMAN|HGNC=9316|UniProtKB=P48454	Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform	IGI	12091710	PubMed	PTHR11668:SF186	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT GAMMA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00012	Cadherin signaling pathway	P00463	betacatenin	XENTR|Xenbase=XB-GENE-487200|UniProtKB=Q28GC2	Catenin (Cadherin associated protein), beta 1, 88kDa	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00059	p53 pathway	P04614	Cyclin B	DICDI|dictyBase=DDB_G0275493|UniProtKB=P42524	G2/mitotic-specific cyclin-B	IDA	95213312	PubMed	PTHR10177:SF347	G2/MITOTIC-SPECIFIC CYCLIN-B
P00052	TGF-beta signaling pathway	P01292	RSmads	DANRE|ZFIN=ZDB-GENE-991119-8|UniProtKB=Q9I8V2	Mothers against decapentaplegic homolog 1	TAS	12736218	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01143	ERK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	CAEEL|WormBase=WBGene00004287|UniProtKB=Q94124	Ras-related protein rac-2	ISS	4757952	gi	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	RAT|RGD=2746|UniProtKB=P31424	Metabotropic glutamate receptor 5	IDA	7476890	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00012	Cadherin signaling pathway	P00465	TCF/LEF	PANTR|Ensembl=ENSPTRG00000012128|UniProtKB=H2QI87	Uncharacterized protein	ISS	9118222	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00056	VEGF signaling pathway	P01407	Erk	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00036	Interleukin signaling pathway	P00976	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DANRE|ZFIN=ZDB-GENE-040718-93|UniProtKB=Q6DGZ5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000000931|UniProtKB=H2PZC4	Protein kinase N2	ISS	11880265	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00020	FAS signaling pathway	P00601	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	11840290	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00006	Apoptosis signaling pathway	P00269	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	IC	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00006	Apoptosis signaling pathway	P00307	ELF2alpha	CAEEL|WormBase=WBGene00021351|UniProtKB=Q9BKU3	Uncharacterized protein	ISS			PTHR10602:SF0	EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	ASHGO|EnsemblGenome=AGOS_ACR225C|UniProtKB=Q75BP6	ACR225Cp	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00034	Integrin signalling pathway	P00923	Arf1	MACMU|Ensembl=ENSMMUG00000002792|UniProtKB=F7H235	ADP-ribosylation factor 1	ISS	12932731	PubMed	PTHR11711:SF294	ADP-RIBOSYLATION FACTOR 3
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	DANRE|ZFIN=ZDB-GENE-030910-1|UniProtKB=X1WBR1	Uncharacterized protein	ISS	2039532	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00021	FGF signaling pathway	P00647	SHP2	TAKRU|Ensembl=ENSTRUG00000018529|UniProtKB=H2VDZ2	Tyrosine-protein phosphatase non-receptor type	ISS	14534538	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P04393	Ras Pathway	P04558	p38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IDA	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00029	Huntington disease	P00796	Kainate receptor	ORNAN|Ensembl=ENSOANG00000002061|UniProtKB=F7ANC6	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00059	p53 pathway	G04697	B99	PANTR|Ensembl=ENSPTRG00000014509|UniProtKB=H2QLW6	G-2 and S-phase expressed 1	ISS	12750368	PubMed	PTHR21584:SF10	G2 AND S PHASE-EXPRESSED PROTEIN 1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000005862|UniProtKB=F1PL99	Phosphoinositide phospholipase C	ISS			PTHR10336:SF84	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	DROME|FlyBase=FBgn0004837|UniProtKB=P28159	Suppressor of hairless protein	NAS			PTHR10665:SF0	SUPPRESSOR OF HAIRLESS PROTEIN
P04393	Ras Pathway	P04550	Ral	CANLF|Ensembl=ENSCAFG00000004844|UniProtKB=E2RLB2	Uncharacterized protein	ISS	7687439	PubMed	PTHR24070:SF199	RAS-RELATED PROTEIN RAL-B
P05916	Opioid prodynorphin pathway	P06002	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MOUSE|MGI=MGI=88179|UniProtKB=Q8BHE5	Bone morphogenetic protein 3	TAS	9759503	PubMed	PTHR11848:SF144	BONE MORPHOGENETIC PROTEIN 3
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00034	Integrin signalling pathway	P00947	Laminin	CANLF|Ensembl=ENSCAFG00000013234|UniProtKB=F1PHK9	Uncharacterized protein	ISS	2538453	PubMed	PTHR10574:SF270	LAMININ SUBUNIT GAMMA-1
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	TAS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00056	VEGF signaling pathway	P01407	Erk	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01142	p90RSK	HUMAN|HGNC=10431|UniProtKB=Q15349	Ribosomal protein S6 kinase alpha-2	ISS	6755374	gi	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	BOVIN|Ensembl=ENSBTAG00000010402|UniProtKB=F1MQ37	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF317	MYOSIN-9
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000022886|UniProtKB=E1BE29	Uncharacterized protein	ISS	15858232	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	CAEEL|WormBase=WBGene00001985|UniProtKB=O02100	Presenilin hop-1	TAS	98004548	PubMed	PTHR10202:SF14	PRESENILIN HOP-1
P00047	PDGF signaling pathway	P01154	Ras	MONDO|Gene=KRAS|UniProtKB=Q07983	GTPase KRas	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ORNAN|Ensembl=ENSOANG00000000460|UniProtKB=F7F4W9	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04542	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00046	Oxidative stress response	P01128	MEF-2	MOUSE|MGI=MGI=99458|UniProtKB=Q8CFN5	Myocyte-specific enhancer factor 2C	TAS	11274345	PubMed	PTHR11945:SF25	MYOCYTE-SPECIFIC ENHANCER FACTOR 2C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00917	ELMO	BOVIN|Gene=ELMO2|UniProtKB=A4FUD6	Engulfment and cell motility protein 2	ISS	12879077	PubMed	PTHR12771:SF8	ENGULFMENT AND CELL MOTILITY PROTEIN 2
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IDA	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00004	Alzheimer disease-presenilin pathway	P00170	Aph-1	RAT|RGD=1311546|UniProtKB=A0A0G2K6H8	Anterior pharynx defective 1a homolog (C. elegans), isoform CRA_a	IDA	12110170	PubMed	PTHR12889:SF3	GAMMA-SECRETASE SUBUNIT APH-1A
P00018	EGF receptor signaling pathway	P00540	MKK3,6	RAT|RGD=1306620|UniProtKB=B1H230	Map2k3 protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04393	Ras Pathway	P04558	p38	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	IDA	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00018	EGF receptor signaling pathway	P00562	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00570	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	IDA	91298951	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P02753	Methionine biosynthesis	P03024	Homocysteine transmethylase	ANOGA|Gene=AgaP_AGAP008537|UniProtKB=Q7PNI0	AGAP008537-PA (Fragment)	ISS			PTHR21091:SF123	FI01821P
P00049	Parkinson disease	P01235	Fyn kinase	TAKRU|Ensembl=ENSTRUG00000014739|UniProtKB=H2UL58	Tyrosine-protein kinase	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01238	14-3-3	MONDO|Ensembl=ENSMODG00000015951|UniProtKB=F7FRT9	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000016758|UniProtKB=H2QQP7	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF290	CADHERIN-10
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00025	Hedgehog signaling pathway	P00682	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00391	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01332	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04413	K+ channel	PANTR|Ensembl=ENSPTRG00000020614|UniProtKB=H2QWR7	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00084	X11alpha	MACMU|Ensembl=ENSMMUG00000009672|UniProtKB=F6YCI6	Uncharacterized protein	ISS	9614075	PubMed	PTHR12345:SF9	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 3
P05915	Opioid proenkephalin pathway	P05994	G-protein	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05943	GRK2	RAT|RGD=2062|UniProtKB=P26817	Beta-adrenergic receptor kinase 1	RCA	8288567	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8972|UniProtKB=O00750	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P05915	Opioid proenkephalin pathway	P05992	met-Enkephalin	DANRE|ZFIN=ZDB-GENE-030729-3|UniProtKB=F1QTD1	Uncharacterized protein (Fragment)	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	RAT|RGD=2746|UniProtKB=P31424	Metabotropic glutamate receptor 5	ISS	12351712	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00011	Blood coagulation	P00411	PAI-1	CANLF|Ensembl=ENSCAFG00000013909|UniProtKB=F1PUI4	Uncharacterized protein	ISS	10692390	PubMed	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00021	FGF signaling pathway	P00636	FGFR1-4	RAT|RGD=2612|UniProtKB=Q498D6	Fibroblast growth factor receptor 4	ISS	92146274	PubMed	PTHR24416:SF343	FIBROBLAST GROWTH FACTOR RECEPTOR 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	DROME|FlyBase=FBgn0003079|UniProtKB=P11346	Raf homolog serine/threonine-protein kinase phl	ISS			PTHR44000:SF2	RAF HOMOLOG SERINE/THREONINE-PROTEIN KINASE PHL
P00010	B cell activation	P00379	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	IDA	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_79607|UniProtKB=C3ZHN4	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P06959	CCKR signaling map	P07228	MAPK1/3	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	RCA	9324163	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00779	TBP	HALSA|EnsemblGenome=VNG_2243G|UniProtKB=Q9HN56	TATA-box-binding protein E	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00898	FKHR	RAT|RGD=1309196|UniProtKB=D3ZBQ1	Forkhead box O3a (Predicted)	ISS	15031210	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00059	p53 pathway	P01486	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00045	Notch signaling pathway	P01099	Notch	BOVIN|Ensembl=ENSBTAG00000007909|UniProtKB=F1MPE9	Uncharacterized protein	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	YARLI|EnsemblGenome=YALI0_D08272g|UniProtKB=Q9UVF3	Actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00047	PDGF signaling pathway	P01146	Ikk	CANLF|Ensembl=ENSCAFG00000005526|UniProtKB=E2RKR0	Uncharacterized protein	RCA			PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P05913	Enkephalin release	P05974	G-Protein (i)	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00018	EGF receptor signaling pathway	P00558	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00046	Oxidative stress response	P01135	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	TAS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00638	PLCgamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00018	EGF receptor signaling pathway	P00563	Gab	MACMU|Ensembl=ENSMMUG00000000694|UniProtKB=F6YZI6	Uncharacterized protein	ISS			PTHR12156:SF21	PLECKSTRIN HOMOLOGY-LIKE DOMAIN FAMILY B MEMBER 2
P00021	FGF signaling pathway	P00627	ERK1-2	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MONDO|Ensembl=ENSMODG00000018204|UniProtKB=F6PGX6	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00049	Parkinson disease	P01212	p38 MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04393	Ras Pathway	P04556	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONBE|Gene=37852|UniProtKB=A9V489	Predicted protein	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	ISS	11535291	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00004	Alzheimer disease-presenilin pathway	P00126	Fe65	MACMU|Ensembl=ENSMMUG00000012563|UniProtKB=F7F3M6	Uncharacterized protein	ISS			PTHR14058:SF11	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 2
P00021	FGF signaling pathway	P00636	FGFR1-4	MONDO|Ensembl=ENSMODG00000008525|UniProtKB=F7DHF8	Fibroblast growth factor receptor	ISS	14507786	PubMed	PTHR24416:SF130	FIBROBLAST GROWTH FACTOR RECEPTOR 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00049	Parkinson disease	P01225	Synphilin	HUMAN|HGNC=11139|UniProtKB=Q9Y6H5	Synphilin-1	IDA	10319874	PubMed	PTHR22882:SF3	SYNPHILIN-1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01095	beta	DROME|FlyBase=FBgn0000038|UniProtKB=P04755	Acetylcholine receptor subunit beta-like 1	ISS	22213672	PubMed	PTHR18945:SF771	ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 1
P00021	FGF signaling pathway	P00624	14-3-3	CANLF|Ensembl=ENSCAFG00000009514|UniProtKB=F1PKW7	Uncharacterized protein	ISS	12618428	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	21150461	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CHICK|Ensembl=ENSGALG00000011809|UniProtKB=F1NMB0	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	176892	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01438	PP2A	MOUSE|MGI=MGI=2388480|UniProtKB=Q6PD28	Protein Ppp2r5b	ISS	10092233	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P06664	Gonadotropin-releasing hormone receptor pathway	P06852	nPKCs	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	RCA	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	RAT|RGD=3251|UniProtKB=Q62829	Serine/threonine-protein kinase PAK 3	ISS	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANAL|CGD=CAL0006065|UniProtKB=Q59LC4	Phosphoinositide phospholipase C	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00019	Endothelin signaling pathway	P00575	furin	CANLF|Ensembl=ENSCAFG00000007882|UniProtKB=E2QX69	Uncharacterized protein	ISS			PTHR42884:SF14	NEUROENDOCRINE CONVERTASE 1
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	IDA	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	HUMAN|HGNC=11331|UniProtKB=P30874	Somatostatin receptor type 2	IDA			PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P00047	PDGF signaling pathway	P01164	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	15210700	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MACMU|Ensembl=ENSMMUG00000021442|UniProtKB=F7EAQ8	Muscarinic acetylcholine receptor	ISS	12915051	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	LEIMA|EnsemblGenome=LmjF.04.1230|UniProtKB=Q9U1E8	Actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00018	EGF receptor signaling pathway	P00565	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	RAT|RGD=1308692|UniProtKB=A0A0G2JTY4	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 (Predicted), isoform CRA_b	ISS	12787506	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	ARATH|TAIR=AT3G06640|UniProtKB=F4JC18	PAS domain-containing tyrosine kinase-like protein	ISS			PTHR44676:SF2	PAS DOMAIN-CONTAINING PROTEIN TYROSINE KINASE-RELATED
P00045	Notch signaling pathway	P01104	Serrate	ORNAN|Ensembl=ENSOANG00000008425|UniProtKB=F6VUQ4	Delta-like protein	ISS	8955070	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04393	Ras Pathway	P04552	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00029	Huntington disease	P00770	N-CoR	MOUSE|MGI=MGI=1337080|UniProtKB=Q9WU42	Nuclear receptor corepressor 2	IPI	11112321	PubMed	PTHR13992:SF21	NUCLEAR RECEPTOR COREPRESSOR 2
P00020	FAS signaling pathway	P00603	Pro-Caspase9	MACMU|Ensembl=ENSMMUG00000018163|UniProtKB=F7FNC1	Caspase	ISS			PTHR10454:SF157	CASPASE-9
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	PANTR|Ensembl=ENSPTRG00000001368|UniProtKB=H2Q045	Uncharacterized protein	ISS	1354612	PubMed	PTHR22952:SF105	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 4
P00057	Wnt signaling pathway	P01471	alpha-catenin	CANLF|Ensembl=ENSCAFG00000001315|UniProtKB=E2R9S7	Uncharacterized protein	ISS	10456847	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00013	Cell cycle	P00480	Proteasome	RAT|RGD=1359305|UniProtKB=Q5XIC6	Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 12	ISS	12477932	PubMed	PTHR10855:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12
P00019	Endothelin signaling pathway	P00567	PKG	TAKRU|Ensembl=ENSTRUG00000010554|UniProtKB=H2TPN4	cGMP-dependent protein kinase	ISS			PTHR24353:SF68	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01433	SIAH-1	RAT|RGD=620449|UniProtKB=Q920M9	E3 ubiquitin-protein ligase SIAH1	ISS	14985507	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PHYPA|Gene=PHYPADRAFT_226658|UniProtKB=A9TYG3	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P06664	Gonadotropin-releasing hormone receptor pathway	P06852	nPKCs	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00048	PI3 kinase pathway	P01202	p85	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	TAS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00053	T cell activation	P01300	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00015	Circadian clock system	G01497	cry	RAT|RGD=735083|UniProtKB=Q32Q86	Cryptochrome-1	IDA	10428031	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	MOUSE|MGI=MGI=95602|UniProtKB=P39688	Tyrosine-protein kinase Fyn	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	TAS	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00059	p53 pathway	P04633	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00801	Fos protein	MACMU|Ensembl=ENSMMUG00000010574|UniProtKB=A5A6H2	C-fos	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	ENTHI|EnsemblGenome=EHI_070730|UniProtKB=C4M5T0	Rho family GTPase	ISS	12932731	PubMed	PTHR24072:SF117	RHO-RELATED PROTEIN RACC
P00057	Wnt signaling pathway	P01452	NFAT	MOUSE|MGI=MGI=103296|UniProtKB=P97305	Nuclear factor of activated T-cells, cytoplasmic 3	IDA	12015605	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_127488|UniProtKB=C3XYC7	Putative uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00005	Angiogenesis	P00213	FGF	MACMU|Ensembl=ENSMMUG00000023509|UniProtKB=F7E243	Fibroblast growth factor	ISS	12799194	PubMed	PTHR11486:SF86	FIBROBLAST GROWTH FACTOR 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04395	Vasopressin synthesis	P04589	Signal Peptidase	DROME|FlyBase=FBgn0039172|UniProtKB=Q9VCA9	Signal peptidase complex subunit 3	IC	1546959	PubMed	PTHR12804:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 3
P00018	EGF receptor signaling pathway	P00545	JNK1-3	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MACMU|Ensembl=ENSMMUG00000018272|UniProtKB=F7HEB8	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	MACMU|Ensembl=ENSMMUG00000022978|UniProtKB=F6U605	Uncharacterized protein	ISS			PTHR23036:SF98	INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	ARATH|TAIR=AT4G34460|UniProtKB=P49177	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF48	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CAEBR|Gene=CBG05858|UniProtKB=A8X1H0	Protein CBR-EGL-19 (Fragment)	ISS	9199552	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PHANO|EnsemblGenome=SNOG_01139|UniProtKB=H2KNE6	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00010	B cell activation	P00400	Btk	ORNAN|Ensembl=ENSOANG00000004224|UniProtKB=F7BKT0	Tyrosine-protein kinase	ISS	10521450	PubMed	PTHR24418:SF92	TYROSINE-PROTEIN KINASE BTK
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	PANTR|Ensembl=ENSPTRG00000000880|UniProtKB=H2R2P9	Uncharacterized protein	ISS			PTHR23359:SF79	ADENYLATE KINASE ISOENZYME 5
P00047	PDGF signaling pathway	P01155	Jak	PANTR|Ensembl=ENSPTRG00000010685|UniProtKB=H2R074	Tyrosine-protein kinase	ISS	15179321	PubMed	PTHR24418:SF233	TYROSINE-PROTEIN KINASE JAK3
P05731	GABA-B receptor II signaling	P05755	Gbeta	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	RCA	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	RCA	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00029	Huntington disease	P00775	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00053	T cell activation	P01305	Calmodulin	ANOGA|EnsemblGenome=AGAP010957|UniProtKB=Q7QGY7	AGAP010957-PA (Fragment)	ISS	10487978	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	CAEEL|WormBase=WBGene00004769|UniProtKB=P52166	Presenilin sel-12	IDA	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	RAT|RGD=620027|UniProtKB=P08911	Muscarinic acetylcholine receptor M5	TAS	11166329	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01199	Galpha	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00047	PDGF signaling pathway	P01167	Ets	PANTR|Ensembl=ENSPTRG00000018065|UniProtKB=H2QSV0	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF182	SAM POINTED DOMAIN-CONTAINING ETS TRANSCRIPTION FACTOR
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00575	furin	CHICK|Ensembl=ENSGALG00000008341|UniProtKB=Q91000	Trans Golgi network protease furin	ISS	10956649	PubMed	PTHR42884:SF1	FURIN
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00181	SHP2	BOVIN|Ensembl=ENSBTAG00000020294|UniProtKB=A5D980	Tyrosine-protein phosphatase non-receptor type	ISS			PTHR19134:SF65	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 6
P00006	Apoptosis signaling pathway	P00269	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02920	dCTP deaminase	BOVIN|Ensembl=ENSBTAG00000026519|UniProtKB=Q5E9J7	tRNA-specific adenosine deaminase 2	ISS			PTHR11079:SF92	TRNA-SPECIFIC ADENOSINE DEAMINASE 2
P00049	Parkinson disease	P01218	alpha-Synuclein	BOVIN|Ensembl=ENSBTAG00000024957|UniProtKB=Q3T0G8	Alpha-synuclein	ISS	9278044	PubMed	PTHR13820:SF5	ALPHA-SYNUCLEIN
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS			PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00111	C99	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P02743	Formyltetrahydroformate biosynthesis	P02952	Methylene tetrahydrofolate dehydrogenase	MACMU|Ensembl=ENSMMUG00000015554|UniProtKB=F6Q8U4	Uncharacterized protein	ISS			PTHR10025:SF42	BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE 2-RELATED
P00004	Alzheimer disease-presenilin pathway	P00127	APP	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00018	EGF receptor signaling pathway	P00554	Shc	MACMU|Ensembl=ENSMMUG00000020357|UniProtKB=F6W915	SHC-transforming protein 3	ISS	9507002	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02738	De novo purine biosynthesis	P02894	IMP cyclohydrolase	CHICK|Gene=ATIC|UniProtKB=P31335	Bifunctional purine biosynthesis protein PURH	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P00023	General transcription regulation	P00668	TFIIB	ORNAN|Ensembl=ENSOANG00000012116|UniProtKB=F7F9P9	Uncharacterized protein	ISS			PTHR12458:SF8	CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MOUSE|MGI=MGI=1351342|UniProtKB=Q3UVX5	Metabotropic glutamate receptor 5	ISS	92317054	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00018	EGF receptor signaling pathway	P00547	PP2A	SCHPO|PomBase=SPBC16H5.07c|UniProtKB=P23636	Major serine/threonine-protein phosphatase PP2A-2 catalytic subunit	ISS			PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00581	Guanylate cyclase	RAT|RGD=2770|UniProtKB=P22717	Guanylate cyclase soluble subunit beta-2	IGI	11406623	PubMed	PTHR11920:SF451	GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IDA	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00010	B cell activation	P00398	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00029	Huntington disease	P00780	Microtubule	DAPPU|EnsemblGenome=DAPPUDRAFT_300845|UniProtKB=E9HEX5	Putative uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF250	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00564	Rac	TAKRU|Ensembl=ENSTRUG00000009931|UniProtKB=H2TJU4	Uncharacterized protein	ISS			PTHR24072:SF150	RAS HOMOLOG GENE FAMILY, MEMBER GA-RELATED
P00017	DNA replication	P00528	Primase	METAC|EnsemblGenome=MA_0648|UniProtKB=Q8TSZ5	DNA primase small subunit PriS	ISS	21929760	PubMed	PTHR10536:SF0	DNA PRIMASE SMALL SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04380	Cortocotropin releasing factor receptor signaling pathway	G04671	proopiomelanocortin	RAT|RGD=3366|UniProtKB=P01194	Pro-opiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	RAT|RGD=2736|UniProtKB=P35439	Glutamate receptor ionotropic, NMDA 1	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00037	Ionotropic glutamate receptor pathway	P01020	NSF	XENTR|Ensembl=ENSXETG00000031364|UniProtKB=F6PIV9	Uncharacterized protein	ISS	11348590	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P02782	Triacylglycerol metabolism	P03205	Triacylglycerol lipase	HUMAN|HGNC=6619|UniProtKB=P11150	Hepatic triacylglycerol lipase	RCA			PTHR11610:SF2	HEPATIC TRIACYLGLYCEROL LIPASE
P00021	FGF signaling pathway	P00623	FGF	RAT|RGD=61805|UniProtKB=Q02195	Fibroblast growth factor 7	ISS	12215437	PubMed	PTHR11486:SF20	FIBROBLAST GROWTH FACTOR 7
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00759	PDEalphabeta	PANTR|Ensembl=ENSPTRG00000017404|UniProtKB=H2QRS2	Phosphodiesterase	ISS	7493036	PubMed	PTHR11347:SF115	ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	NAS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000004896|UniProtKB=F7C2C6	Uncharacterized protein (Fragment)	ISS	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02761	Pantothenate biosynthesis	P03067	3-methyl-2-oxobutanoate hydroxymethyltransferase	SCHPO|PomBase=SPAC5H10.09c|UniProtKB=Q09672	Probable 3-methyl-2-oxobutanoate hydroxymethyltransferase	ISS			PTHR20881:SF0	3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE
P00056	VEGF signaling pathway	P01414	PLC-gamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00021	FGF signaling pathway	P00647	SHP2	DANRE|ZFIN=ZDB-GENE-030131-5911|UniProtKB=F1QZU5	Tyrosine-protein phosphatase non-receptor type	ISS	7681589	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00552	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00050	Plasminogen activating cascade	P01258	Fibrin C-terminal truncation	HUMAN|HGNC=3661|UniProtKB=P02671	Fibrinogen alpha chain	ISS	4503689	gi	PTHR19143:SF232	FIBRINOGEN ALPHA CHAIN
P00036	Interleukin signaling pathway	P00990	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	TAS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	PANTR|Ensembl=ENSPTRG00000013902|UniProtKB=H2RCL0	Uncharacterized protein	ISS	12374786	PubMed	PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=30035|UniProtKB=Q8WYR1	Phosphoinositide 3-kinase regulatory subunit 5	ISS	129387	gi	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00050	Plasminogen activating cascade	P01255	Plasminogen	BOVIN|Gene=PLG|UniProtKB=P06868	Plasminogen	ISS	85203906	PubMed	PTHR24261:SF5	PLASMINOGEN
P00010	B cell activation	P00383	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	94313981	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00030	Hypoxia response via HIF activation	P00819	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01129	JNK1/2	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01001	KA4	MONDO|Ensembl=ENSMODG00000013079|UniProtKB=F7FB74	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	MOUSE|MGI=MGI=1338938|UniProtKB=P36895	Bone morphogenetic protein receptor type-1A	TAS	9395284	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06855	Inha	MOUSE|MGI=MGI=96569|UniProtKB=Q04997	Inhibin alpha chain	RCA			PTHR11848:SF117	INHIBIN ALPHA CHAIN
P00034	Integrin signalling pathway	P00924	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04397	p53 pathway by glucose deprivation	P04641	Akt	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	ISS	12089061	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	BOVIN|Ensembl=ENSBTAG00000010837|UniProtKB=F1N3N9	Uncharacterized protein	ISS	15118808	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P00019	Endothelin signaling pathway	P00580	ET-RA/B	MOUSE|MGI=MGI=105923|UniProtKB=Q61614	Endothelin-1 receptor	ISS	12875994	PubMed	PTHR24243:SF31	ENDOTHELIN-1 RECEPTOR
P00053	T cell activation	P01312	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	RCA	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00054	Toll receptor signaling pathway	P01355	AP1	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00018	EGF receptor signaling pathway	P00544	c-Cbl	RAT|RGD=1561386|UniProtKB=D3ZV15	Protein Cbl	ISS	6680858	gi	PTHR23007:SF5	E3 UBIQUITIN-PROTEIN LIGASE CBL
P00011	Blood coagulation	P00422	FIXa	PANTR|Gene=F9|UniProtKB=Q95ND7	Coagulation factor IX	ISS	14270099	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P00010	B cell activation	P00371	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00046	Oxidative stress response	P01121	MKK3/6	RAT|RGD=620666|UniProtKB=Q925D6	Mitogen-activated protein kinase kinase 6	RCA			PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P06664	Gonadotropin-releasing hormone receptor pathway	P06797	Csda	MOUSE|MGI=MGI=2137670|UniProtKB=Q9JKB3	Y-box-binding protein 3	RCA			PTHR11544:SF14	Y-BOX-BINDING PROTEIN 3
P00034	Integrin signalling pathway	P00938	Cdc42	DROME|FlyBase=FBgn0010341|UniProtKB=P40793	Cdc42 homolog	IDA	9658176	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=12781|UniProtKB=Q93097	Protein Wnt-2b	IDA	8717036	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00047	PDGF signaling pathway	P01153	GSK3	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00029	Huntington disease	P00799	JNK-2	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00007	Axon guidance mediated by semaphorins	P00339	CRMP	HUMAN|HGNC=2365|UniProtKB=Q14194	Dihydropyrimidinase-related protein 1	ISS	96424532	PubMed	PTHR11647:SF54	DIHYDROPYRIMIDINASE-RELATED PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	RAT|RGD=2735|UniProtKB=Q63273	Glutamate receptor ionotropic, kainate 5	ISS	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00036	Interleukin signaling pathway	P00965	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00046	Oxidative stress response	P01124	Myc	RAT|RGD=3130|UniProtKB=P09416	Myc proto-oncogene protein	TAS	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P05913	Enkephalin release	P05972	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P05915	Opioid proenkephalin pathway	P05993	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P02734	Chorismate biosynthesis	P02868	Chorismate synthase	GLOVI|EnsemblGenome=BAC91334|UniProtKB=Q7NFY1	Chorismate synthase	ISS			PTHR21085:SF0	CHORISMATE SYNTHASE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	HUMAN|HGNC=5291|UniProtKB=P28566	5-hydroxytryptamine receptor 1E	ISS	12441358	PubMed	PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	YEAST|SGD=S000006239|UniProtKB=P32288	Glutamine synthetase	ISS			PTHR20852:SF57	GLUTAMINE SYNTHETASE 2 CYTOPLASMIC
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	STRCO|Gene=CAB76355|UniProtKB=Q9L124	Probable aldehyde dehydrogenase	IC			PTHR42986:SF2	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P02738	De novo purine biosynthesis	P02909	GDP reductase	BOVIN|Ensembl=ENSBTAG00000013111|UniProtKB=F1MSF1	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2344|UniProtKB=P08485	Muscarinic acetylcholine receptor M4	IDA	91373358	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IDA	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01153	GSK3	MOUSE|MGI=MGI=105108|UniProtKB=Q61043	Ninein	ISS			PTHR18905:SF11	NINEIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	RCA	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00012	Cadherin signaling pathway	P00475	Frizzled	BOVIN|Ensembl=ENSBTAG00000035084|UniProtKB=F1MLG5	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF22	FRIZZLED-3
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01465	Ggamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00006	Apoptosis signaling pathway	P00303	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	P17325	SPACC	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00018	EGF receptor signaling pathway	P00558	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IGI	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00029	Huntington disease	P00801	Fos protein	MACMU|Ensembl=ENSMMUG00000010574|UniProtKB=A5A6H2	C-fos	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00056	VEGF signaling pathway	P01411	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00021	FGF signaling pathway	P00632	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05916	Opioid prodynorphin pathway	P06000	vasopressin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00011	Blood coagulation	P00437	Kallikrein	MOUSE|MGI=MGI=102849|UniProtKB=P26262	Plasma kallikrein	ISS	6680584	gi	PTHR44459:SF2	PLASMA KALLIKREIN
P00056	VEGF signaling pathway	P01425	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04393	Ras Pathway	P04542	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P06959	CCKR signaling map	G06999	ITGAV	HUMAN|HGNC=6150|UniProtKB=P06756	Integrin alpha-V	RCA	22110279	PubMed	PTHR23220:SF4	INTEGRIN ALPHA-V
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	MOUSE|MGI=MGI=1351340|UniProtKB=Q9QYS2	Metabotropic glutamate receptor 3	ISS	12488551	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00036	Interleukin signaling pathway	P00996	STAT	HUMAN|HGNC=11366|UniProtKB=P42229	Signal transducer and activator of transcription 5A	IDA	96210005	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P05913	Enkephalin release	P05971	CREB	CHICK|Ensembl=ENSGALG00000008494|UniProtKB=Q7SX83	CAMP response element-binding protein	ISS	11390664	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00005	Angiogenesis	P00256	PLC-gamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00020	FAS signaling pathway	P00594	Caspase8	MACMU|Ensembl=ENSMMUG00000012310|UniProtKB=F7DL95	CASP8 and FADD-like apoptosis regulator isoform 1	ISS	9217161	PubMed	PTHR10454:SF8	CASP8 AND FADD-LIKE APOPTOSIS REGULATOR
P05915	Opioid proenkephalin pathway	P05988	peptide E	DANRE|ZFIN=ZDB-GENE-030729-3|UniProtKB=F1QTD1	Uncharacterized protein (Fragment)	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00386	Calcineurin	CANLF|Ensembl=ENSCAFG00000010644|UniProtKB=F2Z4P5	Serine/threonine-protein phosphatase	ISS	12015605	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00546	GAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00056	VEGF signaling pathway	P01408	Akt/PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	14744463	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00025	Hedgehog signaling pathway	P00682	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	7925653	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=1346069|UniProtKB=Q9Z0M3	Cadherin-20	IDA	8120095	PubMed	PTHR24027:SF84	CADHERIN-20
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	XENTR|Ensembl=ENSXETG00000021375|UniProtKB=F6T423	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00006	Apoptosis signaling pathway	P00302	ATF	MONDO|Ensembl=ENSMODG00000009514|UniProtKB=F7EVK3	Uncharacterized protein	ISS	10487205	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04398	p53 pathway feedback loops 2	P04660	SIAH-1	HUMAN|HGNC=10857|UniProtKB=Q8IUQ4	E3 ubiquitin-protein ligase SIAH1	ISS	14985507	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00017	DNA replication	P00538	RNase H	MACMU|Ensembl=ENSMMUG00000014475|UniProtKB=F7GJR4	Ribonuclease H1	ISS	12473655	PubMed	PTHR10642:SF0	RIBONUCLEASE H1
P00059	p53 pathway	G01563	MDM-2	DANRE|ZFIN=ZDB-GENE-990415-153|UniProtKB=O42354	E3 ubiquitin-protein ligase Mdm2	IGI	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_56687|UniProtKB=C3YC50	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01407	Erk	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	BOVIN|Ensembl=ENSBTAG00000005345|UniProtKB=Q3T035	Actin-related protein 2/3 complex subunit 3	ISS	12473693	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00023	General transcription regulation	P00658	TBP-associated factors	PANTR|Ensembl=ENSPTRG00000017345|UniProtKB=H2QRN4	TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa	ISS			PTHR12228:SF6	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 7
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	MOUSE|MGI=MGI=96522|UniProtKB=P31266	Recombining binding protein suppressor of hairless	NAS	15187023	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04393	Ras Pathway	P04566	Stat 1/3	TAKRU|Ensembl=ENSTRUG00000000102|UniProtKB=H2RJA9	Signal transducer and activator of transcription	ISS	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00048	PI3 kinase pathway	P01179	PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00302	ATF	CHICK|Ensembl=ENSGALG00000009287|UniProtKB=O93602	Cyclic AMP-dependent transcription factor ATF-2	ISS	10664585	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	XENTR|Xenbase=XB-GENE-941426|UniProtKB=Q28HZ4	Novel Rho protein	ISS	15668138	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P04393	Ras Pathway	P04547	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00107	kinesin	CAEEL|WormBase=WBGene00002215|UniProtKB=P46822	Kinesin light chain	IDA	11740561	PubMed	PTHR19959:SF207	KINESIN LIGHT CHAIN
P00012	Cadherin signaling pathway	P00465	TCF/LEF	HUMAN|HGNC=11641|UniProtKB=Q9NQB0	Transcription factor 7-like 2	ISS	11266476	PubMed	PTHR10373:SF32	TRANSCRIPTION FACTOR 7-LIKE 2
P00025	Hedgehog signaling pathway	P00682	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	BOVIN|Ensembl=ENSBTAG00000018445|UniProtKB=E1BK87	Uncharacterized protein	ISS	11554549	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	RAT|RGD=621705|UniProtKB=Q8VHN2	Glutamate receptor ionotropic, NMDA 3B	ISS	11319238	PubMed	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P00046	Oxidative stress response	P01129	JNK1/2	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	91056091	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=11438|UniProtKB=Q13277	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00014	Cholesterol biosynthesis	P00491	Hydroxymethyl glutaryl CoA reductase	RAT|RGD=2803|UniProtKB=P51639	3-hydroxy-3-methylglutaryl-coenzyme A reductase	ISS	Q29512	SPACC	PTHR10572:SF2	3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	TAS	98269030	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00775	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P02726	Aminobutyrate degradation	P02824	Succinate semi-aldehyde dehydrogenase	YEAST|SGD=S000000210|UniProtKB=P38067	Succinate-semialdehyde dehydrogenase [NADP(+)]	ISS	12891648	PubMed	PTHR43353:SF5	SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL
P00059	p53 pathway	G04689	Cyclin G	RAT|RGD=2295|UniProtKB=P39950	Cyclin-G1	ISS	11983168	PubMed	PTHR10177:SF59	CYCLIN-G1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00015	Circadian clock system	G01497	cry	PANTR|Ensembl=ENSPTRG00000003537|UniProtKB=H2Q3H0	Uncharacterized protein	ISS	10217146	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01300	ERK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	PANTR|Ensembl=ENSPTRG00000015485|UniProtKB=H2R800	Transient receptor potential cation channel, subfamily C, member 1	ISS	11055438	PubMed	PTHR10117:SF56	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04393	Ras Pathway	P04570	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06703	IGF-1R	MOUSE|MGI=MGI=96433|UniProtKB=Q60751	Insulin-like growth factor 1 receptor	RCA	2877871	PubMed	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00252	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12748278	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00021	FGF signaling pathway	P00645	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12874273	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	XENTR|Xenbase=XB-GENE-944026|UniProtKB=F6VZM7	Adenosine receptor A1 (Fragment)	ISS	12515326	PubMed	PTHR24246:SF1	ADENOSINE RECEPTOR A1
P00029	Huntington disease	P00810	GAPDH	YEAST|SGD=S000003424|UniProtKB=P00359	Glyceraldehyde-3-phosphate dehydrogenase 3	ISS			PTHR10836:SF52	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01093	AChE	MOUSE|MGI=MGI=87876|UniProtKB=P21836	Acetylcholinesterase	IC			PTHR43918:SF3	ACETYLCHOLINESTERASE
P00048	PI3 kinase pathway	P01199	Galpha	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00045	Notch signaling pathway	P01103	Next	CANLF|Ensembl=ENSCAFG00000005627|UniProtKB=E2QUR0	Delta-like protein	ISS	1286675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00012	Cadherin signaling pathway	P00474	Wnt	MACMU|Ensembl=ENSMMUG00000009980|UniProtKB=F6R3A1	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=19663|UniProtKB=Q9UBI6	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=107924|UniProtKB=Q64527	Protein Wnt-8a	IDA	11266476	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00056	VEGF signaling pathway	P01407	Erk	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00036	Interleukin signaling pathway	P00973	PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00470	F-actin	TRIVA|Gene=TVAG_337240|UniProtKB=P90623	Actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-990415-257|UniProtKB=O42376	Mitogen-activated protein kinase 12	IDA	10514528	PubMed	PTHR24055:SF339	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00056	VEGF signaling pathway	P01411	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=2443376|UniProtKB=Q8BIZ0	Protocadherin-20	ISS	8120095	PubMed	PTHR43912:SF7	PROTOCADHERIN-20
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000009594|UniProtKB=G2HFH4	Somatostatin receptor type 2	ISS	12562507	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P00046	Oxidative stress response	P01125	Stat1	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	RCA	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00049	Parkinson disease	P01242	Casein kinase I	ARATH|TAIR=AT3G23340|UniProtKB=Q9LW62	AT3g23340/MLM24_21	IDA	10617630	PubMed	PTHR11909:SF178	CASEIN KINASE 1-LIKE PROTEIN 8
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00003	Alzheimer disease-amyloid secretase pathway	P00095	Nicastrin	MOUSE|MGI=MGI=1891700|UniProtKB=P57716	Nicastrin	IDA	10993067	PubMed	PTHR21092:SF0	NICASTRIN
P00048	PI3 kinase pathway	P01199	Galpha	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BOVIN|Ensembl=ENSBTAG00000014614|UniProtKB=P62739	Actin, aortic smooth muscle	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00019	Endothelin signaling pathway	P00586	Gq	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	CHICK|Ensembl=ENSGALG00000009368|UniProtKB=F1P0K9	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF27	REGULATOR OF G-PROTEIN SIGNALING 6
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	RAT|RGD=1566107|UniProtKB=D3ZBH0	Protein Creb5	RCA			PTHR19304:SF8	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 5
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	EMENI|EnsemblGenome=CADANIAG00002685|UniProtKB=Q5BHB3	Ribonucleotide reductase [Source:UniProtKB/TrEMBLAcc:Q9HEW8]	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00035	Interferon-gamma signaling pathway	P00960	PTP	MONDO|Ensembl=ENSMODG00000018156|UniProtKB=F7CWQ1	Tyrosine-protein phosphatase non-receptor type	ISS	14525967	PubMed	PTHR19134:SF65	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 6
P00044	Nicotinic acetylcholine receptor signaling pathway	P01095	beta	BOVIN|Ensembl=ENSBTAG00000007517|UniProtKB=F1MUN1	Uncharacterized protein	ISS	22213672	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00205	GAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	11847220	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00048	PI3 kinase pathway	P01179	PKB	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CAEEL|WormBase=WBGene00003774|UniProtKB=G5EGQ9	NMDA class glutamate Receptor	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00053	T cell activation	P01324	rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IGI	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00054	Toll receptor signaling pathway	P01369	MKK1	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=69426|UniProtKB=P34975	Kappa-type opioid receptor	IDA	11259498	PubMed	PTHR24229:SF1	KAPPA-TYPE OPIOID RECEPTOR
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHICK|Ensembl=ENSGALG00000009621|UniProtKB=P60706	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00030	Hypoxia response via HIF activation	P00819	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	DROME|Gene=Dmel_CG7904|UniProtKB=A0A0B4KG59	Serine/threonine-protein kinase receptor	TAS	http://flybase.org/reports/FBgn0003169.html	Website	PTHR23255:SF70	SERINE/THREONINE-PROTEIN KINASE RECEPTOR
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00010	B cell activation	P00367	NFAT	MACMU|Ensembl=ENSMMUG00000012657|UniProtKB=F7E7J1	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00055	Transcription regulation by bZIP transcription factor	P01398	TFIIEalpha	RAT|RGD=1306851|UniProtKB=G3V992	General transcription factor II E, polypeptide 1 (Alpha subunit)	ISS	189962	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00029	Huntington disease	P00778	NMDA receptor	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	BOVIN|Ensembl=ENSBTAG00000010119|UniProtKB=G3X6U1	Uncharacterized protein	ISS	14724059	PubMed	PTHR11699:SF102	RETINAL DEHYDROGENASE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00019	Endothelin signaling pathway	P00568	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IGI	22533439	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00018	EGF receptor signaling pathway	P00563	Gab	MACMU|Ensembl=ENSMMUG00000017477|UniProtKB=F6VIK2	Uncharacterized protein	ISS	6753932	gi	PTHR12156:SF4	GRB2-ASSOCIATED-BINDING PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	RAT|RGD=628852|UniProtKB=Q02294	Voltage-dependent N-type calcium channel subunit alpha-1B	IDA	11976940	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00034	Integrin signalling pathway	P00948	Rho	PANTR|Ensembl=ENSPTRG00000040414|UniProtKB=H2RH27	Ras homolog gene family, member B	ISS	11973360	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	MACMU|Ensembl=ENSMMUG00000022577|UniProtKB=Q866A2	Neuronal acetylcholine receptor subunit alpha-7	ISS	85270494	PubMed	PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05915	Opioid proenkephalin pathway	P05994	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00029	Huntington disease	P00767	Pro-caspase 8	PANTR|Ensembl=ENSPTRG00000012801|UniProtKB=H2QJ86	Caspase 8, apoptosis-related cysteine peptidase	ISS	11917123	PubMed	PTHR10454:SF162	CASPASE-8
P00053	T cell activation	P01331	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	HUMAN|HGNC=13735|UniProtKB=P49795	Regulator of G-protein signaling 19	ISS	8756726	PubMed	PTHR10845:SF145	REGULATOR OF G-PROTEIN SIGNALING 19
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04393	Ras Pathway	P04578	Rho	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	IDA	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00036	Interleukin signaling pathway	P00973	PKB	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00898	FKHR	MACMU|Ensembl=ENSMMUG00000020369|UniProtKB=F6UMX8	Uncharacterized protein	ISS	15031210	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P04376	5HT4 type receptor mediated signaling pathway	P04427	5HT4 Receptor	CHICK|Ensembl=ENSGALG00000001383|UniProtKB=F1NJL4	Uncharacterized protein	ISS	12181435	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P04393	Ras Pathway	P04570	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01193	IRS	BOVIN|Ensembl=ENSBTAG00000021308|UniProtKB=F1MYE0	Uncharacterized protein	ISS	5031805	gi	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00056	VEGF signaling pathway	P01410	Caspase9	MACMU|Ensembl=ENSMMUG00000018163|UniProtKB=F7FNC1	Caspase	ISS	8663294	PubMed	PTHR10454:SF157	CASPASE-9
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05734	Synaptic vesicle trafficking	P05779	Synaptobrevin	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	XENTR|Xenbase=XB-GENE-1005779|UniProtKB=F7E3I6	Uncharacterized protein	ISS	11861492	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00057	Wnt signaling pathway	P01446	Calcineurin	MOUSE|MGI=MGI=107162|UniProtKB=P48455	Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform	IDA	12091710	PubMed	PTHR11668:SF186	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT GAMMA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00021	FGF signaling pathway	P00626	Spry	CANLF|Ensembl=ENSCAFG00000006250|UniProtKB=F1Q4C2	Uncharacterized protein	ISS	12027893	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=109356|UniProtKB=O09044	Synaptosomal-associated protein 23	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00019	Endothelin signaling pathway	P00566	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00559	MEK1-2	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00049	Parkinson disease	P01208	Hsp70	ORNAN|Ensembl=ENSOANG00000013291|UniProtKB=F6S4U9	Uncharacterized protein	ISS	10934466	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02916	dTMP kinase	DROME|FlyBase=FBgn0034299|UniProtKB=A1ZB29	CG5757, isoform A	ISS			PTHR10344:SF1	THYMIDYLATE KINASE
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00037	Ionotropic glutamate receptor pathway	P01012	PICK	MOUSE|MGI=MGI=894645|UniProtKB=Q62083	PRKCA-binding protein	ISS	12941441	PubMed	PTHR12141:SF1	PRKCA-BINDING PROTEIN
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00052	TGF-beta signaling pathway	P01286	TGFbeta	PANTR|Ensembl=ENSPTRG00000013439|UniProtKB=H2QK94	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF44	GROWTH/DIFFERENTIATION FACTOR 5
P00052	TGF-beta signaling pathway	P01286	TGFbeta	HUMAN|HGNC=21650|UniProtKB=Q7Z5Y6	Bone morphogenetic protein 8A	TAS	9759503	PubMed	PTHR11848:SF119	BONE MORPHOGENETIC PROTEIN 8A
P05731	GABA-B receptor II signaling	P05754	Ggamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	RCA	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00029	Huntington disease	P00790	beta-Tubulin	CHICK|Ensembl=ENSGALG00000012821|UniProtKB=P32882	Tubulin beta-2 chain	TAS	9454836	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00036	Interleukin signaling pathway	P00977	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	DANRE|ZFIN=ZDB-GENE-000906-4|UniProtKB=B0S5E7	Frizzled homolog 9	TAS	8717036	PubMed	PTHR11309:SF79	FRIZZLED-9
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	IDA	15668138	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	DANRE|ZFIN=ZDB-GENE-040718-414|UniProtKB=D7RVR6	Excitatory amino acid transporter SLC1A1	ISS	94365697	PubMed	PTHR11958:SF69	EXCITATORY AMINO ACID TRANSPORTER 3
P00029	Huntington disease	P00807	Actin	MOUSE|MGI=MGI=2444552|UniProtKB=Q8BFZ3	Beta-actin-like protein 2	IDA	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00024	Glycolysis	P00680	Phosphoglyceromutase	CANLF|Ensembl=ENSCAFG00000003165|UniProtKB=E2QYX1	Uncharacterized protein	ISS	87055234	PubMed	PTHR11931:SF11	BISPHOSPHOGLYCERATE MUTASE
P00049	Parkinson disease	P01226	CDCrel-1	PANTR|Ensembl=ENSPTRG00000023481|UniProtKB=H2R3C4	Septin 2	ISS			PTHR18884:SF67	SEPTIN-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00047	PDGF signaling pathway	P01147	Nck	HUMAN|HGNC=7665|UniProtKB=O43639	Cytoplasmic protein NCK2	ISS	12874226	PubMed	PTHR44108:SF1	CYTOPLASMIC PROTEIN NCK2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00828	Galphai	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	RCA			PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00057	Wnt signaling pathway	P01444	Wnt	XENTR|Xenbase=XB-GENE-485280|UniProtKB=F6X3B2	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00896	Insulin IGF	RAT|RGD=2916|UniProtKB=P01323	Insulin-2	ISS			PTHR11454:SF29	INSULIN-2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=102705|UniProtKB=P63213	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MOUSE|MGI=MGI=1346874|UniProtKB=Q61084	Mitogen-activated protein kinase kinase kinase 3	ISS	11730323	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MACMU|Ensembl=ENSMMUG00000017431|UniProtKB=F7HPP3	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00056	VEGF signaling pathway	P01408	Akt/PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00933	Crk	PANTR|Ensembl=ENSPTRG00000014094|UniProtKB=H2R472	Uncharacterized protein	ISS	8649368	PubMed	PTHR19969:SF9	CRK-LIKE PROTEIN
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P00999	PSD95	MOUSE|MGI=MGI=1930016|UniProtKB=Q4ACU6	SH3 and multiple ankyrin repeat domains protein 3	ISS	20020275	PubMed	PTHR24135:SF4	SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN 3
P00009	Axon guidance mediated by netrin	P00363	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	MOUSE|MGI=MGI=106217|UniProtKB=Q61290	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	11976940	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00053	T cell activation	P01306	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00019	Endothelin signaling pathway	P00591	PLCbeta	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00047	PDGF signaling pathway	P01160	IP3 receptor	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00011	Blood coagulation	P00458	GP IIIa	HUMAN|Ensembl=ENSG00000259753|UniProtKB=H3BM21	Integrin beta (Fragment)	ISS	124968	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IDA	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000012922|UniProtKB=H2QJF2	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P04393	Ras Pathway	P04546	GSK3	CANLF|Ensembl=ENSCAFG00000004882|UniProtKB=F1PAE3	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	CANLF|Ensembl=ENSCAFG00000015094|UniProtKB=F1PT97	Uncharacterized protein	ISS	12473693	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P05916	Opioid prodynorphin pathway	P06002	G-protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01162	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00648	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IGI	22040490	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00059	p53 pathway	G01568	KILLER/DR5	PANTR|Ensembl=ENSPTRG00000020070|UniProtKB=H2QVV8	Uncharacterized protein	ISS	11498783	PubMed	PTHR23097:SF88	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10B
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CANLF|Ensembl=ENSCAFG00000003333|UniProtKB=F1PWT6	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00029	Huntington disease	P00790	beta-Tubulin	TRIVA|Gene=TVAG_008680|UniProtKB=A2DC16	Beta-tubulin, putative	TAS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00019	Endothelin signaling pathway	P00572	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IGI	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00766	Htt	MACMU|Ensembl=ENSMMUG00000008392|UniProtKB=F6VQZ3	Uncharacterized protein	ISS	9462744	PubMed	PTHR10170:SF10	HUNTINGTIN
P02738	De novo purine biosynthesis	P02909	GDP reductase	MACMU|Ensembl=ENSMMUG00000020765|UniProtKB=F7HEG5	Ribonucleoside-diphosphate reductase subunit M2 B	ISS			PTHR23409:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 B
P00021	FGF signaling pathway	P00640	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05918	p38 MAPK pathway	P06013	ELK	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	14670631	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00054	Toll receptor signaling pathway	P01375	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	10540223	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00034	Integrin signalling pathway	P00915	PTP-PEST	PANTR|Ensembl=ENSPTRG00000019337|UniProtKB=H2QUU0	Protein tyrosine phosphatase, non-receptor type 12	ISS	8887669	PubMed	PTHR19134:SF283	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 12
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00211	GSK3beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00046	Oxidative stress response	P01129	JNK1/2	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01444	Wnt	XENTR|Xenbase=XB-GENE-480396|UniProtKB=F7DI28	Protein Wnt (Fragment)	ISS	8717036	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	CAEEL|WormBase=WBGene00016162|UniProtKB=Q4JFH9	CREB Homolog	ISS			PTHR22952:SF147	CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN A
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=621089|UniProtKB=F1LMI3	Cadherin 3, type 1, P-cadherin (Placental)	ISS	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000015241|UniProtKB=Q5IS72	D(3) dopamine receptor	ISS	11861492	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00052	TGF-beta signaling pathway	P01292	RSmads	MACMU|Ensembl=ENSMMUG00000015455|UniProtKB=F6QB58	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF25	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS			PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	HUMAN|HGNC=4584|UniProtKB=Q05586	Glutamate receptor ionotropic, NMDA 1	IC	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	MOUSE|MGI=MGI=106217|UniProtKB=Q61290	Voltage-dependent R-type calcium channel subunit alpha-1E	IDA	14624853	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	XENTR|Xenbase=XB-GENE-478483|UniProtKB=F6W2E6	Glycoprotein hormones alpha chain	ISS	1099091	PubMed	PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P00006	Apoptosis signaling pathway	P00274	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04398	p53 pathway feedback loops 2	P04665	AKT	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	ISS	12719720	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P04376	5HT4 type receptor mediated signaling pathway	P04426	K+ channel	HUMAN|HGNC=6283|UniProtKB=Q9NPC2	Potassium channel subfamily K member 9	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P05916	Opioid prodynorphin pathway	P06000	vasopressin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00054	Toll receptor signaling pathway	P01341	Elk1	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	11151091	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00057	Wnt signaling pathway	P01451	Galpha	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	IDA	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01205	NOS	MOUSE|MGI=MGI=97361|UniProtKB=P29477	Nitric oxide synthase, inducible	ISS	11846418	PubMed	PTHR19384:SF56	NITRIC OXIDE SYNTHASE, INDUCIBLE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CHICK|Gene=ACTG2|UniProtKB=P63270	Actin, gamma-enteric smooth muscle	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00053	T cell activation	P01336	Jnk	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IGI	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00036	Interleukin signaling pathway	P00965	ERK	CANLF|Ensembl=ENSCAFG00000018202|UniProtKB=E2RPJ2	Mitogen-activated protein kinase	ISS	15085193	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P05913	Enkephalin release	P05974	G-Protein (i)	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P06959	CCKR signaling map	G06972	CXCL2	HUMAN|HGNC=4603|UniProtKB=P19875	C-X-C motif chemokine 2	RCA	20671197	PubMed	PTHR10179:SF46	C-X-C MOTIF CHEMOKINE 2
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00036	Interleukin signaling pathway	P00973	PKB	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00624	14-3-3	ORYSJ|EnsemblGenome=OS08G0430500|UniProtKB=Q6ZKC0	14-3-3-like protein GF14-C	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00034	Integrin signalling pathway	P00927	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000010526|UniProtKB=F7B1S0	Uncharacterized protein	ISS			PTHR11824:SF7	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00260	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00049	Parkinson disease	P01242	Casein kinase I	TAKRU|Ensembl=ENSTRUG00000000304|UniProtKB=H2RKM1	Uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00006	Apoptosis signaling pathway	P00276	TRAIL-R	PANTR|Ensembl=ENSPTRG00000020070|UniProtKB=H2QVV8	Uncharacterized protein	ISS	11498783	PubMed	PTHR23097:SF88	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10B
P00054	Toll receptor signaling pathway	P01352	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04398	p53 pathway feedback loops 2	P04657	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	IDA	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01457	GBeta	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	6264430	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	HUMAN|HGNC=9509|UniProtKB=P49810	Presenilin-2	TAS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CAEEL|WormBase=WBGene00001187|UniProtKB=Q8MQA1	Uncharacterized protein	IC	91056091	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00025	Hedgehog signaling pathway	P00685	Smoothened	MACMU|Ensembl=ENSMMUG00000012110|UniProtKB=F7H8W1	Uncharacterized protein	ISS	10021362	PubMed	PTHR11309:SF35	SMOOTHENED HOMOLOG
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	DANRE|ZFIN=ZDB-GENE-020125-5|UniProtKB=A2CG69	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF356	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00737	Rap1GAP	MACMU|Ensembl=ENSMMUG00000002218|UniProtKB=F6W7R2	Uncharacterized protein	ISS	10419452	PubMed	PTHR15711:SF3	RAP1 GTPASE-ACTIVATING PROTEIN 1
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000015178|UniProtKB=F6WI86	Neural cadherin	ISS	8120095	PubMed	PTHR24027:SF79	CADHERIN-2
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00059	p53 pathway	P01480	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00057	Wnt signaling pathway	P01428	Frizzled	XENTR|Xenbase=XB-GENE-483731|UniProtKB=Q5BL72	Frizzled-7	ISS	11212302	PubMed	PTHR11309:SF31	FRIZZLED-7
P00053	T cell activation	P01329	CD45	RAT|RGD=3451|UniProtKB=P04157	Receptor-type tyrosine-protein phosphatase C	IGI	8940015	PubMed	PTHR19134:SF284	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	SCHPO|PomBase=SPBC12D12.04c|UniProtKB=P36583	Protein kinase C-like 2	IC	8491190	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	BOVIN|Gene=FURIN|UniProtKB=Q28193	Furin	IDA	10956649	PubMed	PTHR42884:SF1	FURIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00034	Integrin signalling pathway	P00925	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00241	VEGF	MOUSE|MGI=MGI=103178|UniProtKB=Q00731	Vascular endothelial growth factor A	ISS			PTHR12025:SF5	VASCULAR ENDOTHELIAL GROWTH FACTOR A
P00021	FGF signaling pathway	P00645	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P05734	Synaptic vesicle trafficking	P05780	Rab3A	BOVIN|Ensembl=ENSBTAG00000010635|UniProtKB=P11023	Ras-related protein Rab-3A	RCA			PTHR24073:SF532	RAS-RELATED PROTEIN RAB-3A
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	PANTR|Gene=CHRM2|UniProtKB=Q9N2A7	Muscarinic acetylcholine receptor M2 (Fragment)	ISS	12181435	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	TAKRU|Ensembl=ENSTRUG00000016101|UniProtKB=H2UW32	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CAEBR|Gene=CBG23091|UniProtKB=A8Y4Q9	Protein CBR-ACT-2	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00021	FGF signaling pathway	P00643	Raf-1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	ENTHI|EnsemblGenome=EHI_181250|UniProtKB=C4M5Z7	Rho family GTPase	ISS	8649368	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	MOUSE|MGI=MGI=88296|UniProtKB=O55017	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	15079861	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00005	Angiogenesis	P00243	Raf	MOUSE|MGI=MGI=88190|UniProtKB=P28028	Serine/threonine-protein kinase B-raf	ISS	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02788	Xanthine and guanine salvage pathway	P03247	Xanthine phosphoribosyl transferase	BOVIN|Ensembl=ENSBTAG00000046220|UniProtKB=G3N0T0	Uncharacterized protein	ISS			PTHR43340:SF6	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE
P02762	Pentose phosphate pathway	P03077	D-Ribulo Kinase	ECOLI|EcoGene=EG10053|UniProtKB=P08204	Ribulokinase	RCA			PTHR43435:SF3	RIBULOKINASE
P00047	PDGF signaling pathway	P01152	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	14707121	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00390	Blk	MOUSE|MGI=MGI=88169|UniProtKB=P16277	Tyrosine-protein kinase Blk	IDA	9013950	PubMed	PTHR24418:SF181	TYROSINE-PROTEIN KINASE BLK
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MACMU|Ensembl=ENSMMUG00000012387|UniProtKB=F7EB20	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P05913	Enkephalin release	P05977	G-Protein (s)	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	MOUSE|MGI=MGI=1919519|UniProtKB=P56389	Cytidine deaminase	ISS			PTHR11644:SF2	CYTIDINE DEAMINASE
P00018	EGF receptor signaling pathway	P00539	14-3-3	ORYSJ|EnsemblGenome=OS08G0480800|UniProtKB=Q84J55	14-3-3-like protein GF14-A	ISS	10918058	PubMed	PTHR18860:SF26	14-3-3 FAMILY PROTEIN-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00048	PI3 kinase pathway	P01194	S6K	HUMAN|HGNC=10436|UniProtKB=P23443	Ribosomal protein S6 kinase beta-1	ISS	11861821	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00643	Raf-1	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	ISS			PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	CHICK|Ensembl=ENSGALG00000002098|UniProtKB=F1P0L4	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00052	TGF-beta signaling pathway	P01286	TGFbeta	RAT|RGD=2677|UniProtKB=Q07731	Glial cell line-derived neurotrophic factor	ISS	10779363	PubMed	PTHR12173:SF1	GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR
P05731	GABA-B receptor II signaling	P05755	Gbeta	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00018	EGF receptor signaling pathway	P00554	Shc	ANOGA|EnsemblGenome=AGAP011463|UniProtKB=Q7Q334	AGAP011463-PA	ISS			PTHR10337:SF11	DSHC PROTEIN
P06959	CCKR signaling map	P07194	MAP2K1	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	RCA	15153424	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02785	Valine biosynthesis	P03216	Acetolactate synthase	SULSO|EnsemblGenome=SSO0170|UniProtKB=Q980V7	Acetolactate synthase large subunit homolog (IlvB-1)	ISS			PTHR18968:SF13	ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	CAEBR|Gene=CBG05984|UniProtKB=A8X165	10-formyltetrahydrofolate dehydrogenase	ISS			PTHR11699:SF190	10-FORMYLTETRAHYDROFOLATE DEHYDROGENASE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	IDA	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Gene=CHRM3|UniProtKB=Q9N2A4	Muscarinic acetylcholine receptor M3	IDA			PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00049	Parkinson disease	P01238	14-3-3	DROME|FlyBase=FBgn0004907|UniProtKB=P29310	14-3-3 protein zeta	IDA	10407019	PubMed	PTHR18860:SF13	14-3-3 PROTEIN ZETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	RAT|RGD=628852|UniProtKB=Q02294	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	14624853	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00005	Angiogenesis	P00228	Grb7	MACMU|Ensembl=ENSMMUG00000020775|UniProtKB=F7HC81	Uncharacterized protein	ISS	10521483	PubMed	PTHR11243:SF25	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 7
P00016	Cytoskeletal regulation by Rho GTPase	P00525	N-WASP	MACMU|Ensembl=ENSMMUG00000011544|UniProtKB=F7BU81	Neural Wiskott-Aldrich syndrome protein	ISS	12932731	PubMed	PTHR23202:SF39	NEURAL WISKOTT-ALDRICH SYNDROME PROTEIN
P00005	Angiogenesis	P00236	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01190	PDK1 ACT	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	IGI	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04496	Mdm2	BOVIN|Ensembl=ENSBTAG00000010422|UniProtKB=F1MYE6	Uncharacterized protein	ISS	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00006	Apoptosis signaling pathway	P00274	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02757	O-antigen biosynthesis	P03045	dTDP-glucose 4,6-dehydratase	BACTN|EnsemblGenome=BT_0466|UniProtKB=Q8AAJ8	dTDP-glucose 4,6-dehydratase	ISS			PTHR43000:SF7	DTDP-D-GLUCOSE 4,6-DEHYDRATASE
P00056	VEGF signaling pathway	P01417	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01336	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IGI	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04557	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02738	De novo purine biosynthesis	P02892	5-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase	ECOLI|EcoGene=EG11314|UniProtKB=P0AB89	Adenylosuccinate lyase	ISS			PTHR43411:SF3	ADENYLOSUCCINATE LYASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00020	FAS signaling pathway	P00612	Fas	BOVIN|Ensembl=ENSBTAG00000010785|UniProtKB=P51867	Tumor necrosis factor receptor superfamily member 6	ISS	10327065	PubMed	PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	HUMAN|HGNC=9299|UniProtKB=P67775	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000012922|UniProtKB=H2QJF2	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04633	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00205	GAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	88318957	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05913	Enkephalin release	P05974	G-Protein (i)	RAT|RGD=621516|UniProtKB=G3V6P8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01407	Erk	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	G01529	Proline oxidase	SCHPO|PomBase=SPCC70.03c|UniProtKB=O74524	Probable proline dehydrogenase, mitochondrial	NAS			PTHR13914:SF0	PROLINE DEHYDROGENASE 1, MITOCHONDRIAL
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00012	Cadherin signaling pathway	P00475	Frizzled	HUMAN|HGNC=4047|UniProtKB=O00144	Frizzled-9	IDA	11212302	PubMed	PTHR11309:SF79	FRIZZLED-9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	BOVIN|Ensembl=ENSBTAG00000016352|UniProtKB=E1BQ02	Uncharacterized protein	ISS	10839363	PubMed	PTHR19957:SF106	SYNTAXIN-10
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00628	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00036	Interleukin signaling pathway	P00973	PKB	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01472	Histone deacetylase	ORNAN|Ensembl=ENSOANG00000003631|UniProtKB=F7FJQ1	Histone deacetylase	ISS	10485845	PubMed	PTHR10625:SF171	HISTONE DEACETYLASE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DICDI|dictyBase=DDB_G0279413|UniProtKB=P05987	cAMP-dependent protein kinase regulatory subunit	IC	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00572	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IGI	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00005	Angiogenesis	P00221	JNK1	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05915	Opioid proenkephalin pathway	P05991	Enkephalin	HUMAN|HGNC=8831|UniProtKB=P01210	Proenkephalin-A	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	MOUSE|MGI=MGI=109482|UniProtKB=P97445	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	14507926	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	RAT|RGD=2027|UniProtKB=P63269	Actin, gamma-enteric smooth muscle	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00034	Integrin signalling pathway	P00920	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00023	General transcription regulation	P00666	TFIIE	CANLF|Ensembl=ENSCAFG00000006489|UniProtKB=E2R5J2	Transcription initiation factor IIE subunit beta	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	BOVIN|Ensembl=ENSBTAG00000007599|UniProtKB=Q95KV0	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000003236|UniProtKB=F7DNS6	Uncharacterized protein	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01408	Akt/PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00050	Plasminogen activating cascade	P01254	pro-MMP-13	MOUSE|MGI=MGI=1202395|UniProtKB=O70138	Neutrophil collagenase	ISS			PTHR10201:SF137	NEUTROPHIL COLLAGENASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00038	JAK/STAT signaling pathway	P01027	STAT	CANLF|Ensembl=ENSCAFG00000015346|UniProtKB=E2RE22	Signal transducer and activator of transcription	ISS	14662325	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00005	Angiogenesis	P00193	SOS-1	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IGI	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00011	Blood coagulation	P00458	GP IIIa	HUMAN|Ensembl=ENSG00000259753|UniProtKB=H3BM21	Integrin beta (Fragment)	ISS	7949057	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00049	Parkinson disease	P01208	Hsp70	SCHMA|EnsemblGenome=Smp_106930|UniProtKB=G4V8L4	Putative heat shock protein 70	IDA	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00021	FGF signaling pathway	P00624	14-3-3	PANTR|Ensembl=ENSPTRG00000008521|UniProtKB=G2HI54	14-3-3 protein epsilon	ISS	9450960	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	HUMAN|HGNC=4579|UniProtKB=P39086	Glutamate receptor ionotropic, kainate 1	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	RAT|RGD=2520|UniProtKB=P61169	D(2) dopamine receptor	ISS	2137198	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00003	Alzheimer disease-amyloid secretase pathway	P00094	BACE-1 pro-domain	MACMU|Ensembl=ENSMMUG00000007785|UniProtKB=F7CQI1	Beta-secretase 1 isoform A preproprotein	ISS	10956649	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00021	FGF signaling pathway	P00644	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	ISS	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04393	Ras Pathway	P04561	SRF	BOVIN|Ensembl=ENSBTAG00000012777|UniProtKB=E1BJP4	Uncharacterized protein	ISS	15647354	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00021	FGF signaling pathway	P00638	PLCgamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04398	p53 pathway feedback loops 2	P04657	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00805	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IDA	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	7565716	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00057	Wnt signaling pathway	P01443	Phospholipase C	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00048	PI3 kinase pathway	P01179	PKB	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00646	RasGAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	2574500	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	IC	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	CAEEL|WormBase=WBGene00004769|UniProtKB=P52166	Presenilin sel-12	TAS	7566091	PubMed	PTHR10202:SF13	PRESENILIN-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00577	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	MONDO|Ensembl=ENSMODG00000024440|UniProtKB=F7DJJ2	Muscarinic acetylcholine receptor	ISS	10069496	PubMed	PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00006	Apoptosis signaling pathway	P00310	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IDA	129387	gi	PTHR10048:SF14	PI-3 KINASE
P00056	VEGF signaling pathway	P01411	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00048	PI3 kinase pathway	P01199	Galpha	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	RCA			PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02779	Thiamin biosynthesis	P03175	1-Deoxyxylulose-5-phosphate synthase	STRCO|EnsemblGenome=CAB39701|UniProtKB=Q9X7W3	1-deoxy-D-xylulose-5-phosphate synthase 1	ISS			PTHR43322:SF6	1-DEOXY-D-XYLULOSE-5-PHOSPHATE SYNTHASE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	PANTR|Ensembl=ENSPTRG00000003745|UniProtKB=H2R5D3	Uncharacterized protein	ISS			PTHR10024:SF344	SYNAPTOTAGMIN-7
P04393	Ras Pathway	P04547	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IDA	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	DROME|FlyBase=FBgn0000253|UniProtKB=P62152	Calmodulin	ISS	10487978	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00057	Wnt signaling pathway	P01444	Wnt	CANLF|Ensembl=ENSCAFG00000005291|UniProtKB=E2QXQ3	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00049	Parkinson disease	P01212	p38 MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00005	Angiogenesis	P00240	FRS-2	MONDO|Ensembl=ENSMODG00000020378|UniProtKB=F7F6D5	Uncharacterized protein	ISS	12571252	PubMed	PTHR21258:SF40	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2
P00048	PI3 kinase pathway	P01192	p110	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00144	Ire-1	HUMAN|HGNC=3449|UniProtKB=O75460	Serine/threonine-protein kinase/endoribonuclease IRE1	IDA	10619423	PubMed	PTHR13954:SF17	SERINE/THREONINE-PROTEIN KINASE/ENDORIBONUCLEASE IRE1
P00030	Hypoxia response via HIF activation	P00819	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	BOVIN|Ensembl=ENSBTAG00000011579|UniProtKB=F1N5C5	Muscarinic acetylcholine receptor	ISS	12181435	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00019	Endothelin signaling pathway	P00587	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MONDO|Ensembl=ENSMODG00000006594|UniProtKB=F7AKA6	Uncharacterized protein	ISS	12878610	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	PANTR|Ensembl=ENSPTRG00000014365|UniProtKB=H2R0C8	Casein kinase 1, epsilon	ISS	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	IDA	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	STRCO|Gene=CAA19247|UniProtKB=O69865	Putative lysine/ornithine decarboxylase	ISS			PTHR11482:SF6	ORNITHINE DECARBOXYLASE 1-RELATED
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000008867|UniProtKB=H2QCF3	Mitogen-activated protein kinase	ISS	15085193	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	PLAF7|EnsemblGenome=PFL1110c|UniProtKB=Q7KQK0	CAMP-dependent protein kinase regulatory subunit, putative	ISS	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00624	14-3-3	ENTHI|EnsemblGenome=EHI_025360|UniProtKB=C4M323	14-3-3 protein 1	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00055	Transcription regulation by bZIP transcription factor	P01390	TFIIA complex	DANRE|ZFIN=ZDB-GENE-050522-513|UniProtKB=Q503H9	Transcription initiation factor IIA subunit 2	ISS			PTHR10966:SF0	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00010	B cell activation	P00383	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IDA	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00021	FGF signaling pathway	P00642	MEK1-2	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00010	B cell activation	P00394	BLNK	CHICK|Ensembl=ENSGALG00000006973|UniProtKB=Q9YGC1	B-cell linker protein	IGI	11274146	PubMed	PTHR14098:SF3	B-CELL LINKER PROTEIN
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	RAT|RGD=70487|UniProtKB=Q9WU82	Catenin beta-1	IDA	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P04398	p53 pathway feedback loops 2	P04651	Ras	MONDO|Ensembl=ENSMODG00000025248|UniProtKB=F7F5X1	Uncharacterized protein	ISS	3023884	PubMed	PTHR24070:SF186	GTPASE KRAS
P05731	GABA-B receptor II signaling	P05752	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	XENTR|Xenbase=XB-GENE-480347|UniProtKB=Q6P640	Actin, alpha cardiac muscle 1	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	ORNAN|Ensembl=ENSOANG00000000818|UniProtKB=F6PLI7	Uncharacterized protein	ISS	11431030	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	TAS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00021	FGF signaling pathway	P00642	MEK1-2	CAEBR|Gene=CBG04190|UniProtKB=A8WWD7	Protein CBR-MEK-2	ISS	176872	OMIM	PTHR24361:SF629	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1
P00018	EGF receptor signaling pathway	P00547	PP2A	RAT|RGD=1308022|UniProtKB=D3ZDI7	Protein Ppp2r5a	ISS	10092233	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04546	GSK3	MOUSE|MGI=MGI=2152453|UniProtKB=Q2NL51	Glycogen synthase kinase-3 alpha	ISS	11995474	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P02741	Flavin biosynthesis	P02940	Riboflavin synthase	THEMA|EnsemblGenome=TM_1827|UniProtKB=Q9X2E7	Riboflavin synthase alpha chain	ISS			PTHR21098:SF0	RIBOFLAVIN SYNTHASE
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01146	Ikk	RAT|RGD=620072|UniProtKB=Q8VHU4	Elongator complex protein 1	ISS			PTHR12747:SF0	ELONGATOR COMPLEX PROTEIN 1
P00048	PI3 kinase pathway	P01192	p110	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00005	Angiogenesis	P00223	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00058	mRNA splicing	P01478	U2	BOVIN|Ensembl=ENSBTAG00000027506|UniProtKB=G5E5Y0	Uncharacterized protein	ISS			PTHR10501:SF21	U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B''
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P01486	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00057	Wnt signaling pathway	P01448	CBP	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00036	Interleukin signaling pathway	P00964	p90RSK	HUMAN|HGNC=10435|UniProtKB=Q9UK32	Ribosomal protein S6 kinase alpha-6	IC	6755374	gi	PTHR24351:SF98	RIBOSOMAL PROTEIN S6 KINASE ALPHA-6
P00005	Angiogenesis	P00204	PLD	MACMU|Ensembl=ENSMMUG00000005666|UniProtKB=F6VWY6	Uncharacterized protein	ISS	12615079	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00547	PP2A	CANLF|Ensembl=ENSCAFG00000006453|UniProtKB=F6X958	Serine/threonine-protein phosphatase	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00030	Hypoxia response via HIF activation	P00817	TOR	MACMU|Ensembl=ENSMMUG00000019325|UniProtKB=F6RVV5	Uncharacterized protein	ISS	8662507	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P05915	Opioid proenkephalin pathway	P05994	G-protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	ISS	1482697	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00034	Integrin signalling pathway	P00912	Arp2/3	PANTR|Ensembl=ENSPTRG00000001767|UniProtKB=G2HG81	Actin-related protein 2/3 complex subunit 5	ISS	9230079	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04397	p53 pathway by glucose deprivation	P04641	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01411	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IGI	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P02741	Flavin biosynthesis	P02936	FAD synthetase	FUSNN|EnsemblGenome=FN0707|UniProtKB=Q8RFI9	Riboflavin biosynthesis protein	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	ANOGA|EnsemblGenome=AGAP006475|UniProtKB=Q5TQX0	AGAP006475-PA	ISS	4262086	gi	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00017	DNA replication	P00530	Top	HUMAN|HGNC=11986|UniProtKB=P11387	DNA topoisomerase 1	RCA			PTHR10290:SF5	DNA TOPOISOMERASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	TAS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00005	Angiogenesis	P00201	FVIIa	PANTR|Gene=F7|UniProtKB=Q2F9P2	Coagulation factor VII	ISS	10518503	gi	PTHR44064:SF1	COAGULATION FACTOR VII
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	TAS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00920	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00005	Angiogenesis	P00215	Nck	CANLF|Ensembl=ENSCAFG00000007451|UniProtKB=E2RHV6	Uncharacterized protein	ISS	11689432	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CAEBR|Gene=CBG17587|UniProtKB=A8XRA5	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000006307|UniProtKB=H2SSM1	Uncharacterized protein	ISS			PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00006	Apoptosis signaling pathway	P00269	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DANRE|ZFIN=ZDB-GENE-040426-2564|UniProtKB=F1QX22	Uncharacterized protein	ISS	11067767	PubMed	PTHR19957:SF30	SYNTAXIN-11
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	CAEBR|Gene=CBG05056|UniProtKB=A8WZ27	Protein CBR-GLT-4	ISS	96032356	PubMed	PTHR11958:SF56	SODIUM-DEPENDENT EXCITATORY AMINO ACID TRANSPORTER GLT-4-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00899	IRS 1-4	CANLF|Ensembl=ENSCAFG00000010397|UniProtKB=E2RDB5	Uncharacterized protein	ISS	15110093	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00203	Erk	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00041	Metabotropic glutamate receptor group I pathway	P01062	mGluR1	MACMU|Ensembl=ENSMMUG00000010184|UniProtKB=F6SR09	Uncharacterized protein	ISS			PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00628	JNK1-3	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00648	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05912	Dopamine receptor mediated signaling pathway	P05945	Gsalpha	CHICK|Ensembl=ENSGALG00000007509|UniProtKB=F1NM72	Uncharacterized protein	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DICDI|dictyBase=DDB_G0268622|UniProtKB=P34145	Rho-related protein rac1B	ISS	4757952	gi	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00020	FAS signaling pathway	P00611	Gelsolin	MACMU|Ensembl=ENSMMUG00000000880|UniProtKB=F6T8Z7	Scinderin	ISS	9323209	PubMed	PTHR11977:SF78	ADSEVERIN
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	HUMAN|HGNC=7572|UniProtKB=Q9UKX2	Myosin-2	ISS	10938134	PubMed	PTHR13140:SF385	MYOSIN-2
P05915	Opioid proenkephalin pathway	P05995	proenkephalin	BOVIN|Ensembl=ENSBTAG00000004924|UniProtKB=P01211	Proenkephalin-A	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	GIAIC|EnsemblGenome=GL50803_40817|UniProtKB=A8BV70	Actin related protein	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Ensembl=ENSBTAG00000000914|UniProtKB=Q2KIP6	Kappa-type opioid receptor	ISS	11259487	PubMed	PTHR24229:SF1	KAPPA-TYPE OPIOID RECEPTOR
P00029	Huntington disease	P00777	CBP	BOVIN|Ensembl=ENSBTAG00000016198|UniProtKB=E1B8D6	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00010	B cell activation	P00379	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00049	Parkinson disease	P01237	Complex I	MACMU|Ensembl=ENSMMUG00000001354|UniProtKB=F7D6T1	Uncharacterized protein	ISS	3100899	PubMed	PTHR10371:SF3	NADH DEHYDROGENASE  UBIQUINONE  FLAVOPROTEIN 2, MITOCHONDRIAL
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g188243|UniProtKB=A7SCN8	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00059	p53 pathway	P04630	PP2A	DANRE|ZFIN=ZDB-GENE-040426-2487|UniProtKB=Q803G3	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	RAT|RGD=620683|UniProtKB=P67999	Ribosomal protein S6 kinase beta-1	ISS	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	TAS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00048	PI3 kinase pathway	P01205	NOS	CANLF|Gene=NOS3|UniProtKB=Q9TUX8	Nitric oxide synthase, endothelial	ISS	9837777	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00021	FGF signaling pathway	P00648	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00006	Apoptosis signaling pathway	P00302	ATF	HUMAN|HGNC=785|UniProtKB=P18847	Cyclic AMP-dependent transcription factor ATF-3	ISS	11390664	PubMed	PTHR23351:SF23	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-3
P00018	EGF receptor signaling pathway	P00550	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	8479536	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	LEIMA|EnsemblGenome=LmjF.18.1080|UniProtKB=Q27687	Protein kinase A catalytic subunit	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00036	Interleukin signaling pathway	P00990	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00053	T cell activation	P01305	Calmodulin	BOVIN|Ensembl=ENSBTAG00000001575|UniProtKB=F1N6C0	Uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF311	CALMODULIN
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	HUMAN|HGNC=234|UniProtKB=O60266	Adenylate cyclase type 3	IGI	12623444	PubMed	PTHR11920:SF291	ADENYLATE CYCLASE TYPE 3
P02746	Heme biosynthesis	P02979	porphobilinogen synthase	STRCO|EnsemblGenome=CAB45345|UniProtKB=P54919	Delta-aminolevulinic acid dehydratase	ISS			PTHR11458:SF0	DELTA-AMINOLEVULINIC ACID DEHYDRATASE
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DANRE|ZFIN=ZDB-GENE-030131-55|UniProtKB=Q6XNL8	Actin	IC	10974003	PubMed	PTHR11937:SF263	ACTIN
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	CANLF|Ensembl=ENSCAFG00000003156|UniProtKB=F1PYS6	Uncharacterized protein	ISS			PTHR13140:SF462	MYOSIN-14
P00005	Angiogenesis	P00190	RasGAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	ISS	2842690	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00053	T cell activation	P01322	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	ANOGA|EnsemblGenome=AGAP004476|UniProtKB=Q7QA16	AGAP004476-PA	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00029	Huntington disease	P00786	ARF	BOVIN|Ensembl=ENSBTAG00000007725|UniProtKB=P84080	ADP-ribosylation factor 1	ISS	12932731	PubMed	PTHR11711:SF294	ADP-RIBOSYLATION FACTOR 3
P04397	p53 pathway by glucose deprivation	P04636	S6K	BOVIN|Ensembl=ENSBTAG00000009175|UniProtKB=E1BLQ5	Uncharacterized protein	ISS	6755374	gi	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00019	Endothelin signaling pathway	P00576	Pre-pro ET1-4	CANLF|Ensembl=ENSCAFG00000009794|UniProtKB=P13206	Endothelin-1	ISS			PTHR13874:SF10	ENDOTHELIN-1
P05913	Enkephalin release	P05978	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00049	Parkinson disease	P01230	Src kinase	CANLF|Ensembl=ENSCAFG00000017945|UniProtKB=E2RFF7	Tyrosine-protein kinase	ISS	12665526	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P04397	p53 pathway by glucose deprivation	P04639	AMPK	CANLF|Ensembl=ENSCAFG00000010859|UniProtKB=E2R145	Uncharacterized protein	ISS			PTHR10343:SF45	5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2
P06664	Gonadotropin-releasing hormone receptor pathway	P06786	ERK1/2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	RCA	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	XENTR|Xenbase=XB-GENE-957248|UniProtKB=Q6GLE6	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05731	GABA-B receptor II signaling	P05752	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01162	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05918	p38 MAPK pathway	P06025	SRF	MOUSE|MGI=MGI=106658|UniProtKB=Q9JM73	Serum response factor	ISS	8660892	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00057	Wnt signaling pathway	P01430	p53	HUMAN|HGNC=11998|UniProtKB=P04637	Cellular tumor antigen p53	IDA	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00057	Wnt signaling pathway	P01433	SIAH-1	MOUSE|MGI=MGI=108063|UniProtKB=Q06985	E3 ubiquitin-protein ligase SIAH1B	ISS	15326481	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P05730	Endogenous cannabinoid signaling	P05751	Galpha	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	RCA	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	TAS	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	RAT|RGD=2733|UniProtKB=P42260	Glutamate receptor ionotropic, kainate 2	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P04393	Ras Pathway	P04546	GSK3	RAT|RGD=620351|UniProtKB=P18265	Glycogen synthase kinase-3 alpha	IDA	12086949	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00047	PDGF signaling pathway	P01153	GSK3	RAT|RGD=620351|UniProtKB=P18265	Glycogen synthase kinase-3 alpha	ISS	21361340	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00638	PLCgamma	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	HUMAN|HGNC=143|UniProtKB=P68032	Actin, alpha cardiac muscle 1	IC	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01167	Ets	MACMU|Ensembl=ENSMMUG00000020706|UniProtKB=F6PU72	Uncharacterized protein	ISS	3060801	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00920	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	PANTR|Gene=HTR1E|UniProtKB=Q9N2B6	5-hydroxytryptamine receptor 1E (Fragment)	ISS	11701344	PubMed	PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P00057	Wnt signaling pathway	P01433	SIAH-1	MACMU|Ensembl=ENSMMUG00000015590|UniProtKB=F6TED2	E3 ubiquitin-protein ligase	ISS			PTHR10315:SF11	E3 UBIQUITIN-PROTEIN LIGASE SIAH2
P00018	EGF receptor signaling pathway	P00557	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00021	FGF signaling pathway	P00646	RasGAP	BOVIN|Ensembl=ENSBTAG00000015413|UniProtKB=F1N795	Uncharacterized protein	ISS	20475167	gi	PTHR10194:SF21	RAS GTPASE-ACTIVATING PROTEIN 2
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	BOVIN|Ensembl=ENSBTAG00000035697|UniProtKB=Q28024	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00223	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01465	Ggamma	MONDO|Ensembl=ENSMODG00000000771|UniProtKB=F6SSS3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00012	Cadherin signaling pathway	P00475	Frizzled	PANTR|Ensembl=ENSPTRG00000020122|UniProtKB=H2QVZ0	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF22	FRIZZLED-3
P00003	Alzheimer disease-amyloid secretase pathway	P00095	Nicastrin	ARATH|TAIR=AT3G52640|UniProtKB=Q8GUM5	Nicastrin	IDA	10993067	PubMed	PTHR21092:SF0	NICASTRIN
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04393	Ras Pathway	P04572	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04565	MKK4/7	CHICK|Ensembl=ENSGALG00000001001|UniProtKB=F1P3T1	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	TAKRU|Ensembl=ENSTRUG00000007893|UniProtKB=H2T4Q4	Uncharacterized protein	ISS			PTHR18945:SF751	SUBFAMILY NOT NAMED
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MONDO|Ensembl=ENSMODG00000008900|UniProtKB=F7B4C1	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P02755	Methylmalonyl pathway	P03033	Propionyl-CoA carboxylase	STRCO|Gene=CAC37885|UniProtKB=Q93S05	Putative decarboxylase	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	TAKRU|Ensembl=ENSTRUG00000014690|UniProtKB=H2UKR9	Uncharacterized protein	IDA	11248120	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00048	PI3 kinase pathway	P01199	Galpha	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00053	T cell activation	P01300	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00010	B cell activation	P00397	IKK	PANTR|Ensembl=ENSPTRG00000033948|UniProtKB=H2RBD4	Conserved helix-loop-helix ubiquitous kinase	ISS	12813046	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P02747	Histidine biosynthesis	P02991	Histidinephosphate aminotransferase	SYNY3|EnsemblGenome=BAA17861|UniProtKB=P73807	Histidinol-phosphate aminotransferase	ISS			PTHR42885:SF2	HISTIDINOL-PHOSPHATE AMINOTRANSFERASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	15621031	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04393	Ras Pathway	P04578	Rho	CHICK|Ensembl=ENSGALG00000001569|UniProtKB=Q9PSX7	Rho-related GTP-binding protein RhoC	ISS	12090470	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00049	Parkinson disease	P01211	ERK	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	IDA	20032362	PubMed	PTHR24055:SF330	SUBFAMILY NOT NAMED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	BRAFL|Gene=BRAFLDRAFT_59748|UniProtKB=C3ZEW2	Putative uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF263	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01179	PKB	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	DANRE|ZFIN=ZDB-GENE-000330-9|UniProtKB=Q90ZE4	Presenilin-2	TAS	12424519	PubMed	PTHR10202:SF13	PRESENILIN-2
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	RCA	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00944	Actin	MACMU|Ensembl=ENSMMUG00000012054|UniProtKB=F6TII3	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P04395	Vasopressin synthesis	P04593	Glycopeptide	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01015	Glu4	MACMU|Ensembl=ENSMMUG00000010987|UniProtKB=F7GCX9	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MACMU|Ensembl=ENSMMUG00000022347|UniProtKB=F6ZCH5	Uncharacterized protein	ISS	1648176	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00059	p53 pathway	P04616	PDK1/2	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	TAS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	TAS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00049	Parkinson disease	P01238	14-3-3	CANLF|Ensembl=ENSCAFG00000009514|UniProtKB=F1PKW7	Uncharacterized protein	ISS	9055384	gi	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00056	VEGF signaling pathway	P01421	Rac	HUMAN|HGNC=673|UniProtKB=Q07960	Rho GTPase-activating protein 1	IDA			PTHR23176:SF28	RHO GTPASE-ACTIVATING PROTEIN 1
P00010	B cell activation	P00367	NFAT	PANTR|Ensembl=ENSPTRG00000013628|UniProtKB=H2R4F5	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00054	Toll receptor signaling pathway	P01369	MKK1	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00049	Parkinson disease	P01208	Hsp70	YEAST|SGD=S000003806|UniProtKB=P0CS90	Heat shock protein SSC1, mitochondrial	IDA	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P00059	p53 pathway	P04628	14-3-3	RAT|RGD=1359510|UniProtKB=Q5EBB0	Protein LOC298795	ISS	10407019	PubMed	PTHR18860:SF14	14-3-3 PROTEIN SIGMA
P02757	O-antigen biosynthesis	P03050	dTDP-4-dehydrorhamnose reductase	PSEAE|EnsemblGenome=PA5162|UniProtKB=Q9HU23	dTDP-4-dehydrorhamnose reductase	ISS			PTHR10491:SF4	METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA
P00053	T cell activation	P01298	NFkappaB	MOUSE|MGI=MGI=1099800|UniProtKB=Q9WTK5	Nuclear factor NF-kappa-B p100 subunit	IGI	9133421	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	TAKRU|Ensembl=ENSTRUG00000000321|UniProtKB=H2RKQ7	Uncharacterized protein (Fragment)	ISS			PTHR11606:SF13	GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00830	Lipoxygenase	MOUSE|MGI=MGI=107498|UniProtKB=Q60860	Leukotriene C4 synthase	TAS	11897981	PubMed	PTHR10250:SF4	LEUKOTRIENE C4 SYNTHASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05915	Opioid proenkephalin pathway	P05994	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	HUMAN|HGNC=11534|UniProtKB=Q15572	TATA box-binding protein-associated factor RNA polymerase I subunit C	ISS	20355009	PubMed	PTHR15319:SF1	TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT C
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	HUMAN|HGNC=9300|UniProtKB=P62714	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04543	MEKK1/4	RAT|RGD=1311192|UniProtKB=A0A0G2K3R1	Protein Map3k4	ISS	9079650	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	MOUSE|MGI=MGI=88398|UniProtKB=Q9ERZ3	Muscarinic acetylcholine receptor M3	ISS	8100450	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P02768	Proline biosynthesis	P03112	Glutamate semialdehyde dehydrogenase	STRCO|EnsemblGenome=CAB66263|UniProtKB=Q9RDK1	Gamma-glutamyl phosphate reductase	ISS			PTHR11063:SF8	DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	BOVIN|Ensembl=ENSBTAG00000011723|UniProtKB=E1BKL6	Uncharacterized protein	ISS	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00057	Wnt signaling pathway	P01435	SWI/SNF	DANRE|ZFIN=ZDB-GENE-041114-5|UniProtKB=Q5U379	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1-A	ISS	11532957	PubMed	PTHR10019:SF5	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY B MEMBER 1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	RCA	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05913	Enkephalin release	P05972	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P05731	GABA-B receptor II signaling	P05760	AC	HUMAN|HGNC=235|UniProtKB=Q8NFM4	Adenylate cyclase type 4	ISS	1946437	PubMed	PTHR11920:SF286	ADENYLATE CYCLASE TYPE 4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01155	Jak	MOUSE|MGI=MGI=96629|UniProtKB=Q62120	Tyrosine-protein kinase JAK2	ISS	12686512	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P04384	Gamma-aminobutyric acid synthesis	P04481	Succinic semialdehyde dehydrogenase	BACSU|EnsemblGenome=BSU03910|UniProtKB=P94428	Succinate-semialdehyde dehydrogenase [NADP(+)]	IC	12891648	PubMed	PTHR43353:SF5	SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL
P00053	T cell activation	P01322	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	10477300	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	DICDI|dictyBase=DDB_G0292804|UniProtKB=O96624	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00005	Angiogenesis	P00219	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04392	P53 pathway feedback loops 1	G04682	MDM-2	DANRE|ZFIN=ZDB-GENE-990415-153|UniProtKB=O42354	E3 ubiquitin-protein ligase Mdm2	IGI	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g169611|UniProtKB=A7SEB1	Predicted protein	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	ORNAN|Ensembl=ENSOANG00000007724|UniProtKB=F6QTB5	Uncharacterized protein	ISS	12963527	gi	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00059	p53 pathway	P01486	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	TAS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01219	SAPK	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	NAS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04398	p53 pathway feedback loops 2	P04661	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00558	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00018	EGF receptor signaling pathway	P00543	ERK1-2	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	TAS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04393	Ras Pathway	P04578	Rho	TAKRU|Ensembl=ENSTRUG00000011944|UniProtKB=H2TZX5	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00047	PDGF signaling pathway	P01154	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	ORNAN|Ensembl=ENSOANG00000000999|UniProtKB=F6WN02	Actin-related protein 2/3 complex subunit 5	ISS	10322212	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00006	Apoptosis signaling pathway	P00277	Bi1	ORYSJ|EnsemblGenome=OS02G0125300|UniProtKB=Q9MBD8	Bax inhibitor 1	ISS			PTHR23291:SF34	BAX INHIBITOR 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IDA	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00019	Endothelin signaling pathway	P00588	ET1-4	MOUSE|MGI=MGI=95283|UniProtKB=P22387	Endothelin-1	ISS	15117818	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P00047	PDGF signaling pathway	P01142	p90RSK	PANTR|Ensembl=ENSPTRG00000000387|UniProtKB=H2PYE3	Ribosomal protein S6 kinase	ISS	15226426	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	PANTR|Ensembl=ENSPTRG00000012613|UniProtKB=H2QIY0	Uncharacterized protein	ISS	11907044	PubMed	PTHR44025:SF5	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00011	Blood coagulation	P00419	FXIIIa	HUMAN|HGNC=3534|UniProtKB=P05160	Coagulation factor XIII B chain	ISS	9961357	gi	PTHR19325:SF314	COAGULATION FACTOR XIII B CHAIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	YEAST|SGD=S000005902|UniProtKB=P07262	NADP-specific glutamate dehydrogenase 1	ISS			PTHR43571:SF1	NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	CHICK|Gene=BMPR1B|UniProtKB=Q05438	Bone morphogenetic protein receptor type-1B	IDA			PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P00053	T cell activation	P01319	PAK	PANTR|Ensembl=ENSPTRG00000015787|UniProtKB=H2QP14	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00467	alpha-catenin	MOUSE|MGI=MGI=88274|UniProtKB=P26231	Catenin alpha-1	IDA	1904011	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IGI	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	ANOGA|EnsemblGenome=AGAP002578|UniProtKB=F5HKU8	AGAP002578-PB	ISS	8386525	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P00059	p53 pathway	P01486	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	ANOGA|EnsemblGenome=AGAP001478|UniProtKB=Q7PXM3	AGAP001478-PA	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04542	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00205	GAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	ISS	2842690	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00005	Angiogenesis	P00256	PLC-gamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04393	Ras Pathway	P04567	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IDA	129387	gi	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00036	Interleukin signaling pathway	P00996	STAT	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	15825084	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	8170357	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00021	FGF signaling pathway	P00634	MEKK1-5	MOUSE|MGI=MGI=1346875|UniProtKB=O08648	Mitogen-activated protein kinase kinase kinase 4	IGI	97236778	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00021	FGF signaling pathway	P00633	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IGI	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DROME|FlyBase=FBgn0000044|UniProtKB=P53501	Actin-57B	IC	10974003	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MOUSE|MGI=MGI=99673|UniProtKB=P84309	Adenylate cyclase type 5	ISS	2491850	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P02752	Mannose metabolism	P03018	Mannose 1-P guanylyl transferase	RAT|RGD=1560458|UniProtKB=D4A746	GDP-mannose pyrophosphorylase B (Predicted), isoform CRA_a	ISS	11082198	PubMed	PTHR22572:SF15	MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_56698|UniProtKB=C3XYC3	Putative uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P02779	Thiamin biosynthesis	P03175	1-Deoxyxylulose-5-phosphate synthase	ECOLI|EcoGene=EG13612|UniProtKB=P77488	1-deoxy-D-xylulose-5-phosphate synthase	ISS			PTHR43322:SF6	1-DEOXY-D-XYLULOSE-5-PHOSPHATE SYNTHASE
P00012	Cadherin signaling pathway	P00474	Wnt	BRAFL|Gene=BRAFLDRAFT_113720|UniProtKB=C3YYJ8	Protein Wnt	IDA	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00049	Parkinson disease	P01238	14-3-3	PANTR|Ensembl=ENSPTRG00000014281|UniProtKB=H2QLJ0	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	ISS	10407019	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9441|UniProtKB=P51817	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00005	Angiogenesis	P00221	JNK1	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12176041	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00010	B cell activation	P00391	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01308	ZAP-70	HUMAN|HGNC=12858|UniProtKB=P43403	Tyrosine-protein kinase ZAP-70	IPI	1423621	PubMed	PTHR24418:SF369	TYROSINE-PROTEIN KINASE ZAP-70
P00021	FGF signaling pathway	P00632	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	RAT|RGD=1309504|UniProtKB=D3ZRN3	Protein Actbl2	ISS	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P04393	Ras Pathway	P04541	p90RSK	MONDO|Ensembl=ENSMODG00000006241|UniProtKB=F7FRY0	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00060	Ubiquitin proteasome pathway	P01491	E2	ARATH|TAIR=AT3G55380|UniProtKB=P42747	Ubiquitin-conjugating enzyme E2 14	ISS			PTHR24067:SF174	UBIQUITIN-CONJUGATING ENZYME E2 14
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00038	JAK/STAT signaling pathway	P01034	Jak	DANRE|ZFIN=ZDB-GENE-980526-481|UniProtKB=F1QWX8	Tyrosine-protein kinase	ISS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P06587	Nicotine pharmacodynamics pathway	P06596	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	10521483	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00048	PI3 kinase pathway	P01206	14-3-3	RAT|RGD=3980|UniProtKB=P63102	14-3-3 protein zeta/delta	ISS	1499718	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00705	Gsalpha	BOVIN|Ensembl=ENSBTAG00000002125|UniProtKB=F1N461	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00010	B cell activation	P00402	Jnk	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00036	Interleukin signaling pathway	P00980	IRS1/2	CANLF|Ensembl=ENSCAFG00000010397|UniProtKB=E2RDB5	Uncharacterized protein	ISS	1311924	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	XENTR|Xenbase=XB-GENE-494200|UniProtKB=F7CS79	Uncharacterized protein	ISS	11554554	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00021	FGF signaling pathway	P00631	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	7689150	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00029	Huntington disease	P00790	beta-Tubulin	HUMAN|HGNC=12412|UniProtKB=Q13885	Tubulin beta-2A chain	TAS	12932731	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P00021	FGF signaling pathway	P00627	ERK1-2	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00048	PI3 kinase pathway	P01192	p110	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	HUMAN|HGNC=236|UniProtKB=O95622	Adenylate cyclase type 5	IDA	94139935	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00029	Huntington disease	P00796	Kainate receptor	MONDO|Ensembl=ENSMODG00000013079|UniProtKB=F7FB74	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00006	Apoptosis signaling pathway	P00272	ASK1	MACMU|Ensembl=ENSMMUG00000016376|UniProtKB=F7G2W1	Uncharacterized protein	ISS	8974401	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00010	B cell activation	P00374	Lyn	MOUSE|MGI=MGI=96892|UniProtKB=P25911	Tyrosine-protein kinase Lyn	IDA	1371009	PubMed	PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P00034	Integrin signalling pathway	P00928	alpha actinin	XENTR|Xenbase=XB-GENE-493909|UniProtKB=F7B6G0	Uncharacterized protein	ISS	2116421	PubMed	PTHR43947:SF3	ALPHA-ACTININ-1
P00030	Hypoxia response via HIF activation	P00817	TOR	RAT|RGD=68371|UniProtKB=P42346	Serine/threonine-protein kinase mTOR	TAS	7518356	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	ORYSJ|EnsemblGenome=OS05G0491100|UniProtKB=Q6F332	Calmodulin-2	ISS	3885394	PubMed	PTHR23050:SF324	CALMODULIN-2-RELATED
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	IDA	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	BOVIN|Ensembl=ENSBTAG00000018681|UniProtKB=F1MR49	Uncharacterized protein	ISS	12356903	PubMed	PTHR11267:SF83	BRACHYURY PROTEIN
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00060	Ubiquitin proteasome pathway	P01491	E2	ORYSJ|EnsemblGenome=OS02G0634800|UniProtKB=Q6H7I5	Os02g0634800 protein	ISS			PTHR43902:SF1	UBIQUITIN-CONJUGATING ENZYME E2-21 KDA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ORYSJ|EnsemblGenome=OS03G0285800|UniProtKB=Q10N20	Mitogen-activated protein kinase 5	ISS	10851062	PubMed	PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00591	PLCbeta	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05913	Enkephalin release	P05977	G-Protein (s)	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00012	Cadherin signaling pathway	P00470	F-actin	DICPU|Gene=DICPUDRAFT_46519|UniProtKB=F0Z796	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000035697|UniProtKB=Q28024	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IDA	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=109356|UniProtKB=O09044	Synaptosomal-associated protein 23	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04393	Ras Pathway	P04578	Rho	XENTR|Xenbase=XB-GENE-489222|UniProtKB=Q28GJ8	Ras homolog gene family, member A	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	ANOGA|EnsemblGenome=AGAP010457|UniProtKB=Q7QDW7	AGAP010457-PA	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00053	T cell activation	P01305	Calmodulin	STRPU|EnsemblGenome=SPU_017814|UniProtKB=W4YPT6	Uncharacterized protein	ISS			PTHR23050:SF263	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00251	cPLA2	BOVIN|Ensembl=ENSBTAG00000013298|UniProtKB=A4IFJ5	Cytosolic phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	XENTR|Xenbase=XB-GENE-479599|UniProtKB=F7DHT4	Uncharacterized protein	ISS	9362521	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	BOVIN|Ensembl=ENSBTAG00000000438|UniProtKB=P32236	Gonadotropin-releasing hormone receptor	ISS	12629106	PubMed	PTHR24241:SF22	GONADOTROPIN-RELEASING HORMONE RECEPTOR
P00056	VEGF signaling pathway	P01414	PLC-gamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00036	Interleukin signaling pathway	P00981	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00057	Wnt signaling pathway	P01447	Dishevelled	BOVIN|Ensembl=ENSBTAG00000003075|UniProtKB=E1BK34	Uncharacterized protein	ISS	10409711	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	IC	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00012	Cadherin signaling pathway	P00474	Wnt	MONDO|Ensembl=ENSMODG00000013810|UniProtKB=F6SXE3	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P00060	Ubiquitin proteasome pathway	P01491	E2	SCLS1|EnsemblGenome=SS1G_02922|UniProtKB=A7EC83	Ubiquitin-conjugating enzyme E2	ISS			PTHR43898:SF1	UBIQUITIN-CONJUGATING ENZYME E2-17 KDA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00011	Blood coagulation	P00455	GP IX	PANTR|Ensembl=ENSPTRG00000041466|UniProtKB=H2RF34	Uncharacterized protein	ISS			PTHR22650:SF6	PLATELET GLYCOPROTEIN IX
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	BOVIN|Ensembl=ENSBTAG00000014655|UniProtKB=P10568	Unconventional myosin-Ia	IC			PTHR13140:SF291	UNCONVENTIONAL MYOSIN-IA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	MOUSE|MGI=MGI=1321159|UniProtKB=P63330	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONBE|Gene=37852|UniProtKB=A9V489	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00047	PDGF signaling pathway	P01143	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05913	Enkephalin release	P05974	G-Protein (i)	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01449	Nemo-like Kinase	MOUSE|MGI=MGI=1201387|UniProtKB=O54949	Serine/threonine-protein kinase NLK	ISS	10683140	PubMed	PTHR24055:SF179	SERINE/THREONINE-PROTEIN KINASE NLK
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02729	Ascorbate degradation	P02852	L-xylulose-5-phosphate-3-epimerase	BACSU|EnsemblGenome=BSU15790|UniProtKB=O34557	Ribulose-phosphate 3-epimerase	ISS			PTHR11749:SF3	RIBULOSE-PHOSPHATE 3-EPIMERASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MOUSE|MGI=MGI=1918979|UniProtKB=Q8CGE9	Regulator of G-protein signaling 12	ISS	8756726	PubMed	PTHR10845:SF149	REGULATOR OF G-PROTEIN SIGNALING 12
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	CHICK|Ensembl=ENSGALG00000008058|UniProtKB=F1N8W8	Uncharacterized protein	ISS	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00020	FAS signaling pathway	P00602	DAXX	HUMAN|HGNC=2681|UniProtKB=Q9UER7	Death domain-associated protein 6	IGI	9215629	PubMed	PTHR12766:SF7	DEATH DOMAIN-ASSOCIATED PROTEIN 6
P00009	Axon guidance mediated by netrin	P00361	Ena	MACMU|Ensembl=ENSMMUG00000022938|UniProtKB=F6U702	Uncharacterized protein	ISS			PTHR11202:SF12	VASODILATOR-STIMULATED PHOSPHOPROTEIN
P00053	T cell activation	P01320	PLC-gamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	YARLI|EnsemblGenome=YALI0_D08272g|UniProtKB=Q9UVF3	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00050	Plasminogen activating cascade	P01253	Fibrin	MACMU|Ensembl=ENSMMUG00000021302|UniProtKB=F6UZ87	Uncharacterized protein	ISS	6575700	PubMed	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00057	Wnt signaling pathway	P01437	TCF	MONDO|Ensembl=ENSMODG00000020603|UniProtKB=F6ZBJ4	Uncharacterized protein	ISS	9039917	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00049	Parkinson disease	P01208	Hsp70	TRYB2|Gene=Tb11.02.5450|UniProtKB=Q384Q5	Glucose-regulated protein 78, putative	ISS	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00017	DNA replication	P00529	RFC	MOUSE|MGI=MGI=1341868|UniProtKB=Q9WUK4	Replication factor C subunit 2	RCA			PTHR11669:SF5	REPLICATION FACTOR C SUBUNIT 2
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02772	Pyruvate metabolism	P03136	Malic enzyme	RAT|RGD=3074|UniProtKB=P13697	NADP-dependent malic enzyme	ISS	9954437	gi	PTHR23406:SF17	NADP-DEPENDENT MALIC ENZYME
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IC	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	HUMAN|HGNC=8528|UniProtKB=P01178	Oxytocin-neurophysin 1	ISS	6717565	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06769	Gbeta	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	RCA	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	TAS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02750	Lipoate_biosynthesis	P03004	Lipoate synthase	ORYSJ|Gene=LOC_Os01g56310|UniProtKB=Q5ZAQ2	Lipoyl synthase 1, chloroplastic	ISS			PTHR10949:SF0	LIPOYL SYNTHASE, MITOCHONDRIAL
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00010	B cell activation	P00373	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IGI	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00587	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00047	PDGF signaling pathway	P01161	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01447	Dishevelled	DANRE|ZFIN=ZDB-GENE-010319-1|UniProtKB=B8JMI2	Uncharacterized protein	ISS	10409711	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P00005	Angiogenesis	P00223	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	DANRE|ZFIN=ZDB-GENE-051202-1|UniProtKB=E7F101	Uncharacterized protein	ISS	11319238	PubMed	PTHR44391:SF2	SUBFAMILY NOT NAMED
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	ARATH|TAIR=AT3G17820|UniProtKB=Q9LVI8	Glutamine synthetase cytosolic isozyme 1-3	ISS			PTHR20852:SF79	GLUTAMINE SYNTHETASE CYTOSOLIC ISOZYME 1-1-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000019904|UniProtKB=H2QVN5	Uncharacterized protein	ISS	12181435	PubMed	PTHR24247:SF108	5-HYDROXYTRYPTAMINE RECEPTOR 5A
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	12805548	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02738	De novo purine biosynthesis	P02889	dGDP kinase	SYNY3|EnsemblGenome=BAA18596|UniProtKB=P74494	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00057	Wnt signaling pathway	P01451	Galpha	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00059	p53 pathway	P04609	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00047	PDGF signaling pathway	P01142	p90RSK	RAT|RGD=1563860|UniProtKB=D3Z8E0	Ribosomal protein S6 kinase	ISS	10480933	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00046	Oxidative stress response	P01121	MKK3/6	MOUSE|MGI=MGI=1346870|UniProtKB=P70236	Dual specificity mitogen-activated protein kinase kinase 6	RCA			PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P00046	Oxidative stress response	P01135	p38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	TAS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00628	JNK1-3	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS			PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00046	Oxidative stress response	P01135	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	TAS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00036	Interleukin signaling pathway	P00965	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-990415-257|UniProtKB=O42376	Mitogen-activated protein kinase 12	TAS	10514528	PubMed	PTHR24055:SF339	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00029	Huntington disease	P00790	beta-Tubulin	CAEEL|WormBase=WBGene00006538|UniProtKB=P41937	Tubulin beta-4 chain	TAS	9454836	PubMed	PTHR11588:SF89	TUBULIN BETA-4 CHAIN
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00006	Apoptosis signaling pathway	P00270	Bcl-2	BOVIN|Gene=BCL2|UniProtKB=O02718	Apoptosis regulator Bcl-2	ISS	11323415	PubMed	PTHR11256:SF11	APOPTOSIS REGULATOR BCL-2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00054	Toll receptor signaling pathway	P01352	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00256	PLC-gamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00514	MLCK	RAT|RGD=620934|UniProtKB=P20689	Myosin light chain kinase 2, skeletal/cardiac muscle	TAS	600922	OMIM	PTHR45210:SF1	MYOSIN LIGHT CHAIN KINASE 2, SKELETAL/CARDIAC MUSCLE
P00047	PDGF signaling pathway	P01168	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	14526383	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000010612|UniProtKB=E1C6T4	Serine/threonine-protein kinase	ISS	12676944	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P00034	Integrin signalling pathway	P00951	Jnk	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00052	TGF-beta signaling pathway	P01281	SARA	CANLF|Ensembl=ENSCAFG00000003759|UniProtKB=F6UTI1	Uncharacterized protein	ISS	10733523	PubMed	PTHR22835:SF265	ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PLAF7|EnsemblGenome=PF14_0124|UniProtKB=Q8ILW9	Actin-2	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00021	FGF signaling pathway	P00628	JNK1-3	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	ORNAN|Ensembl=ENSOANG00000013961|UniProtKB=F6VPY1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	CANLF|Ensembl=ENSCAFG00000003333|UniProtKB=F1PWT6	Uncharacterized protein	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P06959	CCKR signaling map	P07039	uPA	HUMAN|HGNC=9052|UniProtKB=P00749	Urokinase-type plasminogen activator	RCA	17575684	PubMed	PTHR24264:SF38	UROKINASE-TYPE PLASMINOGEN ACTIVATOR
P00059	p53 pathway	P04611	P300	MACMU|Ensembl=ENSMMUG00000000893|UniProtKB=F6T7D0	Histone acetyltransferase p300	ISS	10769018	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	XENTR|Xenbase=XB-GENE-488460|UniProtKB=Q6DIY4	TATA box-binding protein-like protein 1	ISS	10470030	PubMed	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05731	GABA-B receptor II signaling	P05752	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	TAS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12912997	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00207	Crk	MACMU|Ensembl=ENSMMUG00000020477|UniProtKB=F6VK11	Crk-like protein	ISS	8649368	PubMed	PTHR19969:SF9	CRK-LIKE PROTEIN
P00018	EGF receptor signaling pathway	P00556	PLCgamma	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00059	p53 pathway	P04633	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	G04702	p53	DANRE|ZFIN=ZDB-GENE-990415-270|UniProtKB=P79734	Cellular tumor antigen p53	TAS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00006	Apoptosis signaling pathway	P00269	MAPK	ORYSJ|EnsemblGenome=OS03G0285800|UniProtKB=Q10N20	Mitogen-activated protein kinase 5	ISS	10527417	PubMed	PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	HUMAN|HGNC=10435|UniProtKB=Q9UK32	Ribosomal protein S6 kinase alpha-6	ISS	15632195	PubMed	PTHR24351:SF98	RIBOSOMAL PROTEIN S6 KINASE ALPHA-6
P00053	T cell activation	P01316	MHC-antigen	HUMAN|HGNC=4943|UniProtKB=P01906	HLA class II histocompatibility antigen, DQ alpha 2 chain	IPI	73139	PubMed	PTHR19944:SF54	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DQ ALPHA 2 CHAIN
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P05916	Opioid prodynorphin pathway	P06001	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	ISS	8557110	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P02748	Isoleucine biosynthesis	P02997	Acetolactate synthase	YEAST|SGD=S000004714|UniProtKB=P07342	Acetolactate synthase catalytic subunit, mitochondrial	ISS			PTHR18968:SF13	ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	11840290	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06738	PLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	RCA	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	CANLF|Ensembl=ENSCAFG00000004381|UniProtKB=J9JH96	Uncharacterized protein	ISS	14614461	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MACMU|Ensembl=ENSMMUG00000009341|UniProtKB=F6UA54	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000024633|UniProtKB=F1MBU9	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00107	kinesin	MONDO|Ensembl=ENSMODG00000013523|UniProtKB=F7D6S9	Uncharacterized protein	ISS	11740561	PubMed	PTHR19959:SF203	KINESIN LIGHT CHAIN 1
P02770	Pyridoxal phosphate salvage pathway	P03120	Pyridoxamine-5-phosphate oxidase	CANLF|Ensembl=ENSCAFG00000016814|UniProtKB=E2QTE2	Uncharacterized protein	ISS	9601034	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00053	T cell activation	P01305	Calmodulin	HUMAN|HGNC=1442|UniProtKB=P62158	Calmodulin	IDA	10487978	PubMed	PTHR23050:SF311	CALMODULIN
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	XENTR|Xenbase=XB-GENE-484012|UniProtKB=F6R871	Serine/threonine-protein kinase receptor	ISS	9395284	PubMed	PTHR23255:SF64	ACTIVIN RECEPTOR TYPE-2A
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05925	beta-ARR1	RAT|RGD=2156|UniProtKB=P29066	Beta-arrestin-1	RCA	9388255	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P04393	Ras Pathway	P04572	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DANRE|ZFIN=ZDB-GENE-040625-35|UniProtKB=Q6IQL9	Novel actin protein	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00057	Wnt signaling pathway	P01471	alpha-catenin	HUMAN|HGNC=2511|UniProtKB=Q9UI47	Catenin alpha-3	IDA	9362521	PubMed	PTHR18914:SF21	CATENIN ALPHA-3
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	RAT|RGD=620340|UniProtKB=O35921	Excitatory amino acid transporter 4	IC	94365697	PubMed	PTHR11958:SF67	EXCITATORY AMINO ACID TRANSPORTER 4
P04387	Histamine synthesis	P04493	Histidine decarboxylase	PANTR|Ensembl=ENSPTRG00000007063|UniProtKB=H2Q9E8	Uncharacterized protein	ISS	1702422	PubMed	PTHR11999:SF68	HISTIDINE DECARBOXYLASE
P00006	Apoptosis signaling pathway	P00260	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01414	PLC-gamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05913	Enkephalin release	P05974	G-Protein (i)	DAPPU|EnsemblGenome=DAPPUDRAFT_59367|UniProtKB=E9H7Z0	Guanine nucleotide-binding protein G(O) subunit alpha 1	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P06664	Gonadotropin-releasing hormone receptor pathway	G06677	Junc	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	RCA	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00054	Toll receptor signaling pathway	P01375	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01145	c-fos	HUMAN|HGNC=11291|UniProtKB=P11831	Serum response factor	ISS			PTHR11945:SF221	SERUM RESPONSE FACTOR
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	12855688	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P02748	Isoleucine biosynthesis	P02994	Branched chain amino acid aminotransferase	HUMAN|HGNC=976|UniProtKB=P54687	Branched-chain-amino-acid aminotransferase, cytosolic	ISS			PTHR11825:SF51	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, CYTOSOLIC
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	8920915	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IC	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00056	VEGF signaling pathway	P01413	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	ISS	8700226	PubMed	PTHR10048:SF14	PI-3 KINASE
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	DANRE|ZFIN=ZDB-GENE-021003-1|UniProtKB=F1QH44	Receptor protein serine/threonine kinase	ISS			PTHR23255:SF66	SERINE/THREONINE-PROTEIN KINASE RECEPTOR R3
P00045	Notch signaling pathway	P01110	Presenilin	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	ISS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00047	PDGF signaling pathway	P01174	Rho	RAT|RGD=1560770|UniProtKB=D4A5B9	Protein Stard8	ISS	8288572	PubMed	PTHR12659:SF3	STAR-RELATED LIPID TRANSFER PROTEIN 8
P00051	TCA cycle	P01270	Malate Dehydrogenase	ORYSJ|EnsemblGenome=OS10G0478200|UniProtKB=Q7XDC8	Malate dehydrogenase, cytoplasmic	IDA	15620222	PubMed	PTHR23382:SF3	MALATE DEHYDROGENASE, CYTOPLASMIC
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00628	JNK1-3	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00049	Parkinson disease	P01211	ERK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	IDA	94131270	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00059	p53 pathway	P04625	Cdk2	PANTR|Ensembl=ENSPTRG00000005070|UniProtKB=H2Q670	Cyclin-dependent kinase 2	ISS	15660127	PubMed	PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P00054	Toll receptor signaling pathway	P01338	IkappaB	RAT|RGD=3171|UniProtKB=Q63746	NF-kappa-B inhibitor alpha	ISS	99081292	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P04398	p53 pathway feedback loops 2	P04651	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P06664	Gonadotropin-releasing hormone receptor pathway	G06902	Atf3	MOUSE|MGI=MGI=109384|UniProtKB=Q60765	Cyclic AMP-dependent transcription factor ATF-3	RCA	11390664	PubMed	PTHR23351:SF23	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-3
P04393	Ras Pathway	P04570	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IDA	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	RAT|RGD=2739|UniProtKB=Q00961	Glutamate receptor ionotropic, NMDA 2C	IC	14698601	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P02757	O-antigen biosynthesis	P03052	N-acetylglucosamine-1-phosphate uridyltransferase	BACSU|EnsemblGenome=BSU00500|UniProtKB=P14192	Bifunctional protein GlmU	ISS			PTHR43584:SF3	BIFUNCTIONAL PROTEIN GLMU
P00018	EGF receptor signaling pathway	P00562	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IGI	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02751	Lysine biosynthesis	P03011	N-succinyldiaminopimelate  aminotransferase	METJA|EnsemblGenome=MJ_0721|UniProtKB=Q58131	Acetylornithine aminotransferase	IDA			PTHR11986:SF79	ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	YEAST|SGD=S000001295|UniProtKB=P07278	cAMP-dependent protein kinase regulatory subunit	IC	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01175	Shc	CANLF|Ensembl=ENSCAFG00000002201|UniProtKB=F1PPW0	Uncharacterized protein	ISS	8760305	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00021	FGF signaling pathway	P00640	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00059	p53 pathway	P01486	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	DANRE|ZFIN=ZDB-GENE-980526-137|UniProtKB=Q98880	Acetylcholine receptor subunit alpha	IC	85270494	PubMed	PTHR18945:SF74	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	ARATH|TAIR=AT5G61210|UniProtKB=Q9S7P9	SNAP25 homologous protein SNAP33	IC			PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04393	Ras Pathway	P04559	Rac	DICDI|dictyBase=DDB_G0279605|UniProtKB=P34148	Rho-related protein racB	ISS	4757952	gi	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00057	Wnt signaling pathway	P01468	APC	RAT|RGD=2123|UniProtKB=P70478	Adenomatous polyposis coli protein	IDA	8259518	PubMed	PTHR12607:SF11	ADENOMATOUS POLYPOSIS COLI PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00054	Toll receptor signaling pathway	P01360	IKKbeta	CANLF|Ensembl=ENSCAFG00000005526|UniProtKB=E2RKR0	Uncharacterized protein	ISS	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P04393	Ras Pathway	P04541	p90RSK	BOVIN|Ensembl=ENSBTAG00000017639|UniProtKB=F1MZW8	Ribosomal protein S6 kinase	ISS	10558991	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00059	p53 pathway	P04623	CBP	ARATH|TAIR=AT1G55970|UniProtKB=Q9LG11	Histone acetyltransferase HAC4	IDA	8413673	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00010	B cell activation	P00383	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00021	FGF signaling pathway	P00629	PP2A	BOVIN|Ensembl=ENSBTAG00000019784|UniProtKB=A4FV68	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	ISS	10092233	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00018	EGF receptor signaling pathway	P00558	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000006307|UniProtKB=H2SSM1	Uncharacterized protein	IC			PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	TAKRU|Ensembl=ENSTRUG00000011297|UniProtKB=H2TV18	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01196	PDK1	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	BOVIN|Ensembl=ENSBTAG00000018705|UniProtKB=F1MPC9	Uncharacterized protein	ISS	12623444	PubMed	PTHR11920:SF291	ADENYLATE CYCLASE TYPE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00626	Spry	HUMAN|HGNC=11271|UniProtKB=O43610	Protein sprouty homolog 3	ISS			PTHR12365:SF9	PROTEIN SPROUTY HOMOLOG 3
P00056	VEGF signaling pathway	P01413	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=1953|UniProtKB=P08173	Muscarinic acetylcholine receptor M4	IDA	11166329	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00010	B cell activation	P00391	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IPI	1171954	gi	PTHR10048:SF14	PI-3 KINASE
P04397	p53 pathway by glucose deprivation	P04639	AMPK	MOUSE|MGI=MGI=108411|UniProtKB=O54950	5'-AMP-activated protein kinase subunit gamma-1	ISS			PTHR13780:SF38	5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1
P00018	EGF receptor signaling pathway	P00551	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IGI	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P02744	Fructose galactose metabolism	P02960	Galactokinase	RAT|RGD=1305375|UniProtKB=Q5RKH2	Galactokinase 1	IDA	14741191	PubMed	PTHR10457:SF6	GALACTOKINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00048	PI3 kinase pathway	P01192	p110	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00011	Blood coagulation	P00420	GP V	RAT|RGD=2724|UniProtKB=O08770	Platelet glycoprotein V	ISS	6980974	gi	PTHR24373:SF144	PLATELET GLYCOPROTEIN V
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CIOIN|Ensembl=ENSCING00000000848|UniProtKB=F6SCP4	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MACMU|Ensembl=ENSMMUG00000022114|UniProtKB=F7H7V5	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF81	FRIZZLED-1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	IC	11956331	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P05916	Opioid prodynorphin pathway	P05999	provasopressin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00018	EGF receptor signaling pathway	P00547	PP2A	MOUSE|MGI=MGI=1349473|UniProtKB=Q61151	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	ISS	11007767	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00054	Toll receptor signaling pathway	P01354	NFkappaB	MACMU|Ensembl=ENSMMUG00000002990|UniProtKB=F7GVV0	Uncharacterized protein	ISS	20151924	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P02738	De novo purine biosynthesis	P02891	GDP kinase	MOUSE|MGI=MGI=1861676|UniProtKB=O88425	Nucleoside diphosphate kinase 6	ISS			PTHR11349:SF70	NUCLEOSIDE DIPHOSPHATE KINASE 6
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	DROME|FlyBase=FBgn0039580|UniProtKB=Q9VAW3	GH12731p	ISS			PTHR10937:SF0	GH12731P-RELATED
P04393	Ras Pathway	P04542	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01326	CD3 delta	CHICK|Ensembl=ENSGALG00000007418|UniProtKB=F1N9E2	Uncharacterized protein	ISS			PTHR10570:SF8	T-CELL SURFACE GLYCOPROTEIN CD3 GAMMA CHAIN
P02749	Leucine biosynthesis	P03001	3-Isopropylmalate dehydrogenase	SCHPO|PomBase=SPBC1A4.02c|UniProtKB=P18869	3-isopropylmalate dehydrogenase	ISS			PTHR42979:SF1	3-ISOPROPYLMALATE DEHYDROGENASE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014555|UniProtKB=F7GT55	Syntaxin-1A isoform 1	ISS	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ANOGA|EnsemblGenome=AGAP000651|UniProtKB=P84185	Actin-5C	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04580	TRH Receptor	HUMAN|HGNC=12299|UniProtKB=P34981	Thyrotropin-releasing hormone receptor	ISS	14599121	PubMed	PTHR24243:SF115	THYROTROPIN-RELEASING HORMONE RECEPTOR
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	TAS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02787	Vitamin B6 metabolism	P03229	Pyridoxal reductase	SCHPO|PomBase=SPCC1281.04|UniProtKB=O94521	Probable pyridoxal reductase 2	ISS	11859360	PubMed	PTHR43625:SF14	PYRIDOXAL REDUCTASE-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00006	Apoptosis signaling pathway	P00268	GCK	MOUSE|MGI=MGI=1346882|UniProtKB=P70218	Mitogen-activated protein kinase kinase kinase kinase 1	ISS			PTHR24361:SF88	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P06959	CCKR signaling map	P07019	RHOA-GDP	HUMAN|HGNC=667|UniProtKB=P61586	Transforming protein RhoA	RCA	15331357	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00036	Interleukin signaling pathway	P00981	SOS	CHICK|Ensembl=ENSGALG00000013224|UniProtKB=F1NMA4	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02788	Xanthine and guanine salvage pathway	P03247	Xanthine phosphoribosyl transferase	MYCTU|EnsemblGenome=Rv3624c|UniProtKB=P9WHQ9	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	SCHPO|PomBase=SPBC1778.10c|UniProtKB=Q9Y7J6	Serine/threonine-protein kinase ppk21	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	CHICK|Ensembl=ENSGALG00000015434|UniProtKB=F1NU20	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IDA	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00057	Wnt signaling pathway	P01427	Naked	RAT|RGD=1308491|UniProtKB=D4AAV5	Protein Nkd1	ISS	11356022	PubMed	PTHR22611:SF2	PROTEIN NAKED CUTICLE HOMOLOG 1
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00941	Integrin alpha	RAT|RGD=1310333|UniProtKB=D3ZQM3	Integrin alpha 3 variant B	ISS	3487386	PubMed	PTHR23220:SF89	INTEGRIN ALPHA-3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00029	Huntington disease	P00807	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g210933|UniProtKB=A7SEA7	Predicted protein	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00036	Interleukin signaling pathway	P00975	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	14707121	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02723	Adenine and hypoxanthine salvage pathway	P02807	Deoxyadenosine deaminase	ARATH|TAIR=AT4G04880|UniProtKB=Q8LPL7	Adenosine deaminase-like protein	ISS			PTHR11409:SF42	ADENOSINE DEAMINASE-LIKE PROTEIN
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CHICK|Ensembl=ENSGALG00000000059|UniProtKB=F1NMU4	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1170702	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05966	EPB41	MACMU|Ensembl=ENSMMUG00000019418|UniProtKB=F6R9F7	Uncharacterized protein	ISS	12181426	PubMed	PTHR23280:SF20	BAND 4.1-LIKE PROTEIN 3
P00018	EGF receptor signaling pathway	P00551	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	IGI	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00470	F-actin	ORYSJ|EnsemblGenome=OS03G0836000|UniProtKB=Q10AZ4	Actin-3	IC	14684598	PubMed	PTHR11937:SF254	ACTIN-1-RELATED
P06209	ALP23B signaling pathway	P06219	LACK	DROME|FlyBase=FBgn0029006|UniProtKB=Q9V853	E3 ubiquitin-protein ligase Smurf1	IEA	11252892	PubMed	PTHR11254:SF395	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00048	PI3 kinase pathway	P01192	p110	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01238	14-3-3	PANTR|Ensembl=ENSPTRG00000008521|UniProtKB=G2HI54	14-3-3 protein epsilon	ISS	98119747	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00034	Integrin signalling pathway	P00940	Src	MOUSE|MGI=MGI=98397|UniProtKB=P05480	Neuronal proto-oncogene tyrosine-protein kinase Src	ISS	8054685	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000000323|UniProtKB=H2PYA3	Uncharacterized protein	ISS	12181435	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00036	Interleukin signaling pathway	P00983	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00925	MEK	DROME|FlyBase=FBgn0024326|UniProtKB=O61444	MAP kinase kinase 4, isoform A	IDA	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00008	Axon guidance mediated by Slit/Robo	P00348	Robo	XENTR|Xenbase=XB-GENE-948809|UniProtKB=F6WF30	Uncharacterized protein	ISS			PTHR44096:SF1	ROUNDABOUT HOMOLOG 1
P00003	Alzheimer disease-amyloid secretase pathway	P00108	ADAM10	DROME|FlyBase=FBgn0259984|UniProtKB=Q9VJW9	Kuzbanian, isoform A	IDA	10097139	PubMed	PTHR11905:SF209	KUZBANIAN, ISOFORM A
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MACMU|Ensembl=ENSMMUG00000005441|UniProtKB=F7GQ00	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF29	INHIBIN BETA B CHAIN
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	DANRE|ZFIN=ZDB-GENE-991119-4|UniProtKB=Q9W6T7	Presenilin-1	IDA	12101103	PubMed	PTHR10202:SF18	PRESENILIN-1
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	TAS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04453	ACTH	PANTR|Ensembl=ENSPTRG00000011721|UniProtKB=H2R8Y3	Uncharacterized protein	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00053	T cell activation	P01294	NFAT	RAT|RGD=1308692|UniProtKB=A0A0G2JTY4	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 (Predicted), isoform CRA_b	ISS	9462517	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00021	FGF signaling pathway	P00646	RasGAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	IPI	8262392	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04393	Ras Pathway	P04558	p38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IDA	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00018	EGF receptor signaling pathway	P00564	Rac	BOVIN|Ensembl=ENSBTAG00000004110|UniProtKB=E1BLE9	Uncharacterized protein	ISS			PTHR24072:SF150	RAS HOMOLOG GENE FAMILY, MEMBER GA-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04379	Beta3 adrenergic receptor signaling pathway	P04449	Beta3	MACMU|Ensembl=ENSMMUG00000005876|UniProtKB=Q28524	Beta-3 adrenergic receptor	ISS	12063255	PubMed	PTHR24248:SF3	BETA-3 ADRENERGIC RECEPTOR
P00046	Oxidative stress response	P01131	MKP5	ANOGA|EnsemblGenome=AGAP002108|UniProtKB=F5HMZ9	AGAP002108-PB	ISS			PTHR10159:SF418	LD31102P
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	IC	91072385	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	RAT|RGD=2831|UniProtKB=P25102	Histamine H2 receptor	IDA	11841575	PubMed	PTHR43893:SF5	HISTAMINE H2 RECEPTOR
P00034	Integrin signalling pathway	P00951	Jnk	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00059	p53 pathway	P01486	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	TAS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	RCA	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00627	ERK1-2	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000000440|UniProtKB=H2PYH8	Uncharacterized protein	ISS	11259498	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00053	T cell activation	P01312	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04393	Ras Pathway	P04546	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00047	PDGF signaling pathway	P01174	Rho	PANTR|Ensembl=ENSPTRG00000023245|UniProtKB=H2R481	Uncharacterized protein	ISS			PTHR14166:SF8	SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 3
P00029	Huntington disease	P00811	Arp2/3 complex	DANRE|ZFIN=ZDB-GENE-040120-7|UniProtKB=Q7ZWH4	Actin-related protein 2/3 complex subunit 5	TAS	12932731	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	RAT|RGD=2944|UniProtKB=P24898	Transcription factor jun-B	TAS	10664585	PubMed	PTHR11462:SF37	TRANSCRIPTION FACTOR JUN-B
P00048	PI3 kinase pathway	P01179	PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	CAEEL|WormBase=WBGene00006570|UniProtKB=O16273	TransformIng Growth factor beta family	TAS	9759503	PubMed	PTHR11848:SF54	PROTEIN 60A-RELATED
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04395	Vasopressin synthesis	P04597	Signal Peptide	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00012	Cadherin signaling pathway	P00470	F-actin	DICDI|dictyBase=DDB_G0289487|UniProtKB=P07829	Actin-3	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02788	Xanthine and guanine salvage pathway	P03250	Guanosine phosphorylase	DROME|FlyBase=FBgn0035348|UniProtKB=M9PE19	Uncharacterized protein, isoform H	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00057	Wnt signaling pathway	P01457	GBeta	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	DANRE|ZFIN=ZDB-GENE-030131-688|UniProtKB=Q7T2P7	Glutamine synthetase	ISS			PTHR20852:SF43	GLUTAMINE SYNTHETASE
P00056	VEGF signaling pathway	P01409	cPLA2	BOVIN|Ensembl=ENSBTAG00000013298|UniProtKB=A4IFJ5	Cytosolic phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	XENTR|Xenbase=XB-GENE-957124|UniProtKB=F7BDN8	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00010	B cell activation	P00384	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IDA	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	MONDO|Ensembl=ENSMODG00000019823|UniProtKB=F6SB23	Uncharacterized protein (Fragment)	ISS	94365697	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	IDA	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00023	General transcription regulation	P00658	TBP-associated factors	BOVIN|Ensembl=ENSBTAG00000030966|UniProtKB=Q58DG7	TBP-associated factor 6 isoform alpha	ISS			PTHR10221:SF12	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01465	Ggamma	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00018	EGF receptor signaling pathway	P00565	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00056	VEGF signaling pathway	P01411	Ras	DICPU|Gene=DICPUDRAFT_57324|UniProtKB=F0ZVH9	Putative uncharacterized protein rasS	ISS	8290260	PubMed	PTHR24070:SF380	RAS-LIKE PROTEIN RASS
P00021	FGF signaling pathway	P00642	MEK1-2	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	ISS	3487386	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P02738	De novo purine biosynthesis	P02889	dGDP kinase	ORNAN|Ensembl=ENSOANG00000011750|UniProtKB=F6TWB9	Nucleoside diphosphate kinase	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P00060	Ubiquitin proteasome pathway	P01494	19S proteasome	BOVIN|Gene=PSMC4|UniProtKB=Q3T030	26S protease regulatory subunit 6B	ISS			PTHR23073:SF8	26S PROTEASE REGULATORY SUBUNIT 6B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00049	Parkinson disease	P01219	SAPK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	HUMAN|HGNC=4580|UniProtKB=Q13002	Glutamate receptor ionotropic, kainate 2	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P02731	Biotin biosynthesis	P02858	8-Amino-7-oxononanoate synthase	BACTN|EnsemblGenome=BT_1443|UniProtKB=Q8A7T1	8-amino-7-oxononanoate synthase	ISS			PTHR13693:SF59	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00970	Interleukin	HUMAN|HGNC=5962|UniProtKB=P22301	Interleukin-10	IC			PTHR44875:SF1	INTERLEUKIN-10
P06959	CCKR signaling map	P07088	RYR1/2/3	HUMAN|HGNC=10484|UniProtKB=Q92736	Ryanodine receptor 2	RCA	10590314	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00056	VEGF signaling pathway	P01414	PLC-gamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	RAT|RGD=620594|UniProtKB=G3V7C3	CCR4-NOT transcription complex subunit 6	IC	12009564	PubMed	PTHR10489:SF608	C-C CHEMOKINE RECEPTOR TYPE 4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	HUMAN|HGNC=1389|UniProtKB=Q00975	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	8386525	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	XENTR|Xenbase=XB-GENE-491356|UniProtKB=Q28J24	Transcription initiation factor TFIID subunit 8	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	DANRE|ZFIN=ZDB-GENE-020125-5|UniProtKB=A2CG69	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF356	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04558	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	IDA	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00543	ERK1-2	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00052	TGF-beta signaling pathway	P01284	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00049	Parkinson disease	P01227	20S proteasome	HUMAN|HGNC=9536|UniProtKB=O14818	Proteasome subunit alpha type-7	ISS	12859888	PubMed	PTHR11599:SF40	PROTEASOME SUBUNIT ALPHA TYPE-7
P00005	Angiogenesis	P00190	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	88318957	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06768	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	RCA	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	IDA	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-010705-1|UniProtKB=Q90Z40	Guanine nucleotide-binding protein subunit gamma	IC	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00057	Wnt signaling pathway	P01457	GBeta	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IDA	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P02725	Allantoin degradation	P02817	Glycerate kinase II	STRCO|Gene=CAB39872|UniProtKB=Q9X804	Putative glycerate kinase	ISS			PTHR21599:SF0	SUBFAMILY NOT NAMED
P06664	Gonadotropin-releasing hormone receptor pathway	P06819	SMAD2-4	MOUSE|MGI=MGI=894293|UniProtKB=P97471	Mothers against decapentaplegic homolog 4	RCA	10693808	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	MACMU|Ensembl=ENSMMUG00000008722|UniProtKB=F7E161	Uncharacterized protein	ISS			PTHR43382:SF2	BIFUNCTIONAL GLUTAMATE/PROLINE--TRNA LIGASE
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=7572|UniProtKB=Q9UKX2	Myosin-2	IC	10938134	PubMed	PTHR13140:SF385	MYOSIN-2
P00049	Parkinson disease	P01208	Hsp70	PANTR|Ensembl=ENSPTRG00000000563|UniProtKB=H2PYQ3	Heat shock 70kDa protein 5 (Glucose-regulated protein, 78kDa)	ISS	10934466	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00047	PDGF signaling pathway	P01143	ERK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MOUSE|MGI=MGI=98328|UniProtKB=P30875	Somatostatin receptor type 2	ISS			PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=99218|UniProtKB=P39038	Cadherin-4	IDA	8120095	PubMed	PTHR24027:SF81	CADHERIN-4
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00898	FKHR	MOUSE|MGI=MGI=1890081|UniProtKB=Q9WVH4	Forkhead box protein O3	ISS	15031210	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P04393	Ras Pathway	P04547	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000009607|UniProtKB=F7A586	5-hydroxytryptamine receptor 2C	ISS			PTHR24247:SF32	5-HYDROXYTRYPTAMINE RECEPTOR 2C
P00050	Plasminogen activating cascade	P01254	pro-MMP-13	PANTR|Ensembl=ENSPTRG00000004222|UniProtKB=H2Q4N4	Uncharacterized protein	ISS	8207000	PubMed	PTHR10201:SF165	COLLAGENASE 3
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	HUMAN|HGNC=4587|UniProtKB=Q14957	Glutamate receptor ionotropic, NMDA 2C	ISS	11554549	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02738	De novo purine biosynthesis	P02902	ADP reductase	METAC|EnsemblGenome=MA_1665|UniProtKB=Q8TQ86	Ribonucleotide reductase	ISS			PTHR43371:SF1	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04546	GSK3	PANTR|Ensembl=ENSPTRG00000011049|UniProtKB=H2QGF9	Glycogen synthase kinase 3 alpha	ISS	11995474	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00019	Endothelin signaling pathway	P00589	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00474	Wnt	MACMU|Ensembl=ENSMMUG00000017346|UniProtKB=F7H9B8	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P00029	Huntington disease	P00790	beta-Tubulin	TRIAD|EnsemblGenome=TriadG63686|UniProtKB=B3RQ31	Beta-tubulin	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000001384|UniProtKB=F7GL73	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	PANTR|Ensembl=ENSPTRG00000007489|UniProtKB=H2QA49	Tyrosine-protein kinase receptor	ISS	249616	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	AQUAE|EnsemblGenome=aq_2104|UniProtKB=O67872	Acetyl-coenzyme A synthetase	ISS			PTHR24095:SF14	ACETYL-COENZYME A SYNTHETASE 1
P05915	Opioid proenkephalin pathway	P05995	proenkephalin	RAT|RGD=68946|UniProtKB=P04094	Proenkephalin-A	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00005	Angiogenesis	P00190	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	11847220	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00057	Wnt signaling pathway	P01440	Cadherin	ANOGA|EnsemblGenome=AGAP006732|UniProtKB=Q7PT75	AGAP006732-PA	ISS	8120095	PubMed	PTHR24026:SF71	FAT-LIKE CADHERIN-RELATED TUMOR SUPPRESSOR HOMOLOG
P04376	5HT4 type receptor mediated signaling pathway	P04426	K+ channel	MOUSE|MGI=MGI=1100509|UniProtKB=O35111	Potassium channel subfamily K member 3	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	MOUSE|MGI=MGI=1931052|UniProtKB=A6ZI47	Fructose-bisphosphate aldolase	ISS	3391172	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	8787761	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00053	T cell activation	P01312	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	PANTR|Ensembl=ENSPTRG00000003699|UniProtKB=H2Q3R5	Syntaxin 3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	PANTR|Ensembl=ENSPTRG00000018684|UniProtKB=C7G3M7	Glutamate receptor, metabotropic 1	ISS	9407094	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00053	T cell activation	P01311	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00036	Interleukin signaling pathway	P00996	STAT	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	IC	12461178	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000011757|UniProtKB=Q9XT97	Presenilin-1	IDA	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00051	TCA cycle	P01268	Aconitase	PANTR|Ensembl=ENSPTRG00000014428|UniProtKB=H2QLS4	Uncharacterized protein	RCA			PTHR43160:SF3	ACONITATE HYDRATASE, MITOCHONDRIAL
P00006	Apoptosis signaling pathway	P00284	Flip	PANTR|Ensembl=ENSPTRG00000012798|UniProtKB=H2R695	CASP8 and FADD-like apoptosis regulator	ISS	8681376	PubMed	PTHR10454:SF8	CASP8 AND FADD-LIKE APOPTOSIS REGULATOR
P00046	Oxidative stress response	P01131	MKP5	BOVIN|Ensembl=ENSBTAG00000020961|UniProtKB=A6H7A7	DUSP19 protein	ISS			PTHR10159:SF402	DUAL SPECIFICITY PROTEIN PHOSPHATASE 19
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IDA	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00022	General transcription by RNA polymerase I	P00652	RNA Polymerase I  Complex	SCHPO|PomBase=SPAC18G6.11c|UniProtKB=Q10110	RNA polymerase I-specific transcription initiation factor rrn3	ISS			PTHR12790:SF0	RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN3-RELATED
P00059	p53 pathway	G04702	p53	RAT|RGD=3889|UniProtKB=P10361	Cellular tumor antigen p53	TAS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00011	Blood coagulation	P00418	Fibrin monomer	RAT|RGD=2603|UniProtKB=P06399	Fibrinogen alpha chain	ISS	87134033	PubMed	PTHR19143:SF232	FIBRINOGEN ALPHA CHAIN
P02755	Methylmalonyl pathway	P03034	Methylmalonyl-CoA mutase	ORNAN|Ensembl=ENSOANG00000008261|UniProtKB=F6YLX9	Uncharacterized protein	ISS			PTHR42710:SF1	METHYLMALONYL-COA MUTASE, MITOCHONDRIAL
P00029	Huntington disease	P00780	Microtubule	RAT|RGD=1305887|UniProtKB=Q4QQV0	Protein Tubb6	IDA	12932731	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00036	Interleukin signaling pathway	P00981	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04393	Ras Pathway	P04547	Ras	MACMU|Ensembl=ENSMMUG00000015381|UniProtKB=F6SFG7	Uncharacterized protein	ISS	6287573	PubMed	PTHR24070:SF186	GTPASE KRAS
P00029	Huntington disease	P00775	Rac	MONDO|Ensembl=ENSMODG00000024005|UniProtKB=F7A4B3	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF158	RHO-RELATED GTP-BINDING PROTEIN RHOG
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	PANTR|Ensembl=ENSPTRG00000003795|UniProtKB=H2Q3X5	Muscarinic acetylcholine receptor	ISS	8100450	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00021	FGF signaling pathway	P00633	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00018	EGF receptor signaling pathway	P00563	Gab	RAT|RGD=1311085|UniProtKB=A0A0G2JZD5	Protein Gab1	ISS	12584127	gi	PTHR12156:SF18	GRB2-ASSOCIATED-BINDING PROTEIN 1
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00054	Toll receptor signaling pathway	P01358	ERK1	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	IPI	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00029	Huntington disease	P00796	Kainate receptor	BOVIN|Ensembl=ENSBTAG00000011723|UniProtKB=E1BKL6	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P05915	Opioid proenkephalin pathway	P05990	K+ channel	MOUSE|MGI=MGI=1100509|UniProtKB=O35111	Potassium channel subfamily K member 3	ISS	15282272	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	DANRE|ZFIN=ZDB-GENE-000210-28|UniProtKB=Q9PTS6	Chico protein	IDA	9783586	PubMed	PTHR10814:SF4	AMINO-TERMINAL ENHANCER OF SPLIT-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04397	p53 pathway by glucose deprivation	P04639	AMPK	MOUSE|MGI=MGI=1336173|UniProtKB=Q8BRK8	5'-AMP-activated protein kinase catalytic subunit alpha-2	ISS			PTHR24343:SF303	5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-2
P00056	VEGF signaling pathway	P01408	Akt/PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01167	Ets	PANTR|Ensembl=ENSPTRG00000005811|UniProtKB=H2Q7G8	E74-like factor 1 (Ets domain transcription factor)	ISS	15298723	PubMed	PTHR11849:SF156	ETS-RELATED TRANSCRIPTION FACTOR ELF-1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00012	Cadherin signaling pathway	P00477	GSK3beta	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00048	PI3 kinase pathway	P01205	NOS	RAT|RGD=3186|UniProtKB=Q62600	Nitric oxide synthase, endothelial	ISS	9837777	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P06959	CCKR signaling map	P07146	ELK1	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	RCA	20843811	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	DROME|FlyBase=FBgn0022710|UniProtKB=M9PEP2	Adenylyl cyclase 35C, isoform C	IDA	97431620	PubMed	PTHR11920:SF319	ADENYLATE CYCLASE TYPE 9
P00034	Integrin signalling pathway	P00922	Collagen	MONDO|Ensembl=ENSMODG00000002306|UniProtKB=F6YDU5	Uncharacterized protein	ISS	10778855	PubMed	PTHR44057:SF2	COLLAGEN ALPHA-1 VIII  CHAIN
P00021	FGF signaling pathway	P00642	MEK1-2	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MONDO|Ensembl=ENSMODG00000001303|UniProtKB=F7BZM9	Uncharacterized protein (Fragment)	ISS	12932731	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P05915	Opioid proenkephalin pathway	P05989	leu-Enkephalin	PANTR|Ensembl=ENSPTRG00000020270|UniProtKB=H2QW70	Proenkephalin	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MACMU|Ensembl=ENSMMUG00000021442|UniProtKB=F7EAQ8	Muscarinic acetylcholine receptor	ISS	8100450	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	DROME|FlyBase=FBgn0010051|UniProtKB=P29993	Inositol 1,4,5-trisphosphate receptor	ISS	4262086	gi	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00014	Cholesterol biosynthesis	P00498	Hydroxymethyl glutaryl CoA synthase	MOUSE|MGI=MGI=107592|UniProtKB=Q8JZK9	Hydroxymethylglutaryl-CoA synthase, cytoplasmic	ISS	123332	gi	PTHR43323:SF4	HYDROXYMETHYLGLUTARYL-COA SYNTHASE, CYTOPLASMIC
P04393	Ras Pathway	P04570	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00269	MAPK	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DANRE|ZFIN=ZDB-GENE-040426-1178|UniProtKB=Q7SY24	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IDA	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	ARATH|TAIR=AT4G34340|UniProtKB=Q9SYZ9	Transcription initiation factor TFIID subunit 8	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00018	EGF receptor signaling pathway	P00562	p38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00012	Cadherin signaling pathway	P00471	Cadherin	MONDO|Ensembl=ENSMODG00000004059|UniProtKB=F7BIQ7	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF290	CADHERIN-10
P00053	T cell activation	P01300	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00059	p53 pathway	P04609	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000022175|UniProtKB=F6XHY0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P02749	Leucine biosynthesis	P03000	Branched chain amino acid aminotransferase	MACMU|Ensembl=ENSMMUG00000012223|UniProtKB=F6VFZ3	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF51	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, CYTOSOLIC
P04398	p53 pathway feedback loops 2	P04657	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00983	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	IC	14744463	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00053	T cell activation	P01324	rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00053	T cell activation	P01335	jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IC	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00036	Interleukin signaling pathway	P00987	SRF	RAT|RGD=1559787|UniProtKB=D3ZHH8	Protein Srf	ISS	15170389	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	BOVIN|Ensembl=ENSBTAG00000008026|UniProtKB=P01175	Oxytocin-neurophysin 1	ISS	3768139	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00054	Toll receptor signaling pathway	P01372	IKKepsilon	MACMU|Ensembl=ENSMMUG00000002526|UniProtKB=F7GM52	Uncharacterized protein	ISS			PTHR22969:SF10	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT EPSILON
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04454	CRF	XENTR|Ensembl=ENSXETG00000030233|UniProtKB=F6XHX7	Uncharacterized protein	ISS	122560	OMIM	PTHR15035:SF9	CORTICOLIBERIN
P00024	Glycolysis	P00673	Triosephosphate isomerase	MOUSE|MGI=MGI=98797|UniProtKB=P17751	Triosephosphate isomerase	RCA			PTHR21139:SF15	TRIOSEPHOSPHATE ISOMERASE
P00048	PI3 kinase pathway	P01202	p85	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05913	Enkephalin release	P05974	G-Protein (i)	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	IC	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02738	De novo purine biosynthesis	P02891	GDP kinase	MOUSE|MGI=MGI=97356|UniProtKB=Q01768	Nucleoside diphosphate kinase B	ISS			PTHR11349:SF57	NUCLEOSIDE DIPHOSPHATE KINASE B
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00012	Cadherin signaling pathway	P00466	EGFR	HUMAN|HGNC=3430|UniProtKB=P04626	Receptor tyrosine-protein kinase erbB-2	ISS	4758298	gi	PTHR24416:SF137	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00629	PP2A	PANTR|Ensembl=ENSPTRG00000042450|UniProtKB=H2R9V8	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B	ISS	11956189	PubMed	PTHR11871:SF2	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B ALPHA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	TAS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05913	Enkephalin release	P05974	G-Protein (i)	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00852	PYK2	MACMU|Ensembl=ENSMMUG00000019159|UniProtKB=F6SS49	Uncharacterized protein	ISS	12640026	PubMed	PTHR24418:SF94	PROTEIN-TYROSINE KINASE 2-BETA
P00045	Notch signaling pathway	P01114	Ntm	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	TAKRU|Ensembl=ENSTRUG00000005300|UniProtKB=H2SJZ5	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00056	VEGF signaling pathway	P01411	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05917	Opioid proopiomelanocortin pathway	P06006	beta-Endorphin	RAT|RGD=3366|UniProtKB=P01194	Pro-opiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Gene=ACTA2|UniProtKB=P08023	Actin, aortic smooth muscle	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00005	Angiogenesis	P00203	Erk	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00054	Toll receptor signaling pathway	P01346	TLR	MACMU|Gene=TLR2|UniProtKB=B3Y618	Toll-like receptor 2	ISS			PTHR24365:SF17	TOLL-LIKE RECEPTOR 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00896	Insulin IGF	BOVIN|Ensembl=ENSBTAG00000011082|UniProtKB=P07455	Insulin-like growth factor I	ISS			PTHR11454:SF4	INSULIN-LIKE GROWTH FACTOR I
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IC	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01275	P38	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	TAS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04393	Ras Pathway	P04560	AP1	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00056	VEGF signaling pathway	P01414	PLC-gamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00017	DNA replication	P00527	Histones	PHANO|Gene=SNOG_03319|UniProtKB=Q0UY45	Histone H3	ISS	12413958	PubMed	PTHR11426:SF169	HISTONE H3
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00054	Toll receptor signaling pathway	P01344	TRIF	PANTR|Ensembl=ENSPTRG00000039473|UniProtKB=B3Y699	TIR domain-containing adaptor molecule 2	ISS	22716271	PubMed	PTHR22811:SF75	TIR DOMAIN-CONTAINING ADAPTER MOLECULE 2
P00053	T cell activation	P01300	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00752	cGMP-gated ion channel	HUMAN|HGNC=2153|UniProtKB=Q9NQW8	Cyclic nucleotide-gated cation channel beta-3	IDA	12432397	PubMed	PTHR10217:SF385	CYCLIC NUCLEOTIDE-GATED CATION CHANNEL BETA-3
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	PANTR|Ensembl=ENSPTRG00000020490|UniProtKB=H2R2C6	Frizzled homolog 6	ISS	8717036	PubMed	PTHR11309:SF75	FRIZZLED-6
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000040496|UniProtKB=H2RF32	Uncharacterized protein	ISS	8120095	PubMed	PTHR43912:SF3	PROTOCADHERIN-1
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00211	GSK3beta	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ASHGO|EnsemblGenome=AGOS_ABR222W|UniProtKB=Q75D00	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00589	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01020	NSF	XENTR|Ensembl=ENSXETG00000031364|UniProtKB=F6PIV9	Uncharacterized protein	ISS	601633	OMIM	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00010	B cell activation	P00384	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00029	Huntington disease	P00805	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	RAT|RGD=619712|UniProtKB=Q63651	Rhodopsin kinase	IDA	8260489	PubMed	PTHR24355:SF11	RHODOPSIN KINASE
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00048	PI3 kinase pathway	P01181	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IPI	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05918	p38 MAPK pathway	P06039	MSK2	BOVIN|Ensembl=ENSBTAG00000039153|UniProtKB=F1MQE1	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF41	RIBOSOMAL PROTEIN S6 KINASE ALPHA-4
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	ISS	10704417	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00015	Circadian clock system	P00502	Casein kinase I	DANRE|ZFIN=ZDB-GENE-030131-825|UniProtKB=Q7T2E3	Casein kinase I isoform delta-A	ISS	11437445	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00012	Cadherin signaling pathway	P00464	Fyn	TAKRU|Ensembl=ENSTRUG00000003538|UniProtKB=H2S7D1	Tyrosine-protein kinase	ISS	9741627	PubMed	PTHR24418:SF242	TYROSINE-PROTEIN KINASE FYNB
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	RCA	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01015	Glu4	MONDO|Ensembl=ENSMODG00000014746|UniProtKB=F6YN64	Uncharacterized protein (Fragment)	ISS	12941441	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	DANRE|ZFIN=ZDB-GENE-030407-2|UniProtKB=F8W5D0	Uncharacterized protein (Fragment)	ISS			PTHR11681:SF13	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00547	PP2A	CANLF|Ensembl=ENSCAFG00000015787|UniProtKB=F6V7D9	Uncharacterized protein	ISS	11007767	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04552	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00036	Interleukin signaling pathway	P00965	ERK	RAT|RGD=628675|UniProtKB=Q9Z2A6	Mitogen-activated protein kinase 15	TAS	10851062	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00048	PI3 kinase pathway	P01188	Gbetagamma	DROME|FlyBase=FBgn0004623|UniProtKB=P29829	Guanine nucleotide-binding protein subunit beta-2	ISS	9754712	PubMed	PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00049	Parkinson disease	P01224	UbcH7	BOVIN|Gene=UBE2L3|UniProtKB=Q3MHP1	Ubiquitin-conjugating enzyme E2 L3	ISS	10888878	PubMed	PTHR24068:SF67	UBIQUITIN-CONJUGATING ENZYME E2 L3
P04393	Ras Pathway	P04578	Rho	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00021	FGF signaling pathway	P00623	FGF	MACMU|Ensembl=ENSMMUG00000007419|UniProtKB=F6SXE2	Fibroblast growth factor	ISS	91095983	PubMed	PTHR11486:SF83	FIBROBLAST GROWTH FACTOR 2
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IGI	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	CHICK|Ensembl=ENSGALG00000008058|UniProtKB=F1N8W8	Uncharacterized protein	ISS	7559398	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00005	Angiogenesis	P00238	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00018	EGF receptor signaling pathway	P00562	p38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	TAS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00021	FGF signaling pathway	P00627	ERK1-2	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00110	Ire-1 N-terminal fragment	CANLF|Ensembl=ENSCAFG00000011784|UniProtKB=F1P7G9	Uncharacterized protein	ISS	10619423	PubMed	PTHR13954:SF17	SERINE/THREONINE-PROTEIN KINASE/ENDORIBONUCLEASE IRE1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000017374|UniProtKB=F7H6T7	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P06664	Gonadotropin-releasing hormone receptor pathway	P06768	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	RCA	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	CAEEL|WormBase=WBGene00000195|UniProtKB=P51485	Probable beta-arrestin	IC	11742073	PubMed	PTHR11792:SF17	KURTZ ARRESTIN
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	XENTR|Xenbase=XB-GENE-481480|UniProtKB=Q5XGI6	Casein kinase 1, epsilon	ISS	11865049	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	PANTR|Gene=HTR2C|UniProtKB=Q5IS66	5-hydroxytryptamine receptor 2C	ISS	12181435	PubMed	PTHR24247:SF32	5-HYDROXYTRYPTAMINE RECEPTOR 2C
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00023	General transcription regulation	P00664	TFIIH complex	HUMAN|HGNC=4655|UniProtKB=P32780	General transcription factor IIH subunit 1	ISS			PTHR12856:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MACMU|Ensembl=ENSMMUG00000022347|UniProtKB=F6ZCH5	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01171	PLCgamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00052	TGF-beta signaling pathway	P01275	P38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	TAS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01199	Galpha	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	IC	8838318	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9062|UniProtKB=Q9BRC7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	10934033	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02749	Leucine biosynthesis	P03000	Branched chain amino acid aminotransferase	SYNY3|EnsemblGenome=BAA10792|UniProtKB=P54691	Probable branched-chain-amino-acid aminotransferase	ISS			PTHR42743:SF4	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IC	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MACMU|Ensembl=ENSMMUG00000018272|UniProtKB=F7HEB8	Uncharacterized protein	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT3G45640|UniProtKB=Q39023	Mitogen-activated protein kinase 3	ISS	11707292	PubMed	PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00645	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00578	eNOS	HUMAN|HGNC=7876|UniProtKB=P29474	Nitric oxide synthase, endothelial	ISS	22462730	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEEL|WormBase=WBGene00004033|UniProtKB=P90980	Protein kinase C-like 2	ISS	3045562	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00054	Toll receptor signaling pathway	P01341	Elk1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	ISS	14670631	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00037	Ionotropic glutamate receptor pathway	P01026	KA	PANTR|Ensembl=ENSPTRG00000011042|UniProtKB=H2QGF5	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00019	Endothelin signaling pathway	P00572	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00029	Huntington disease	P00771	Sin3A	BOVIN|Ensembl=ENSBTAG00000009330|UniProtKB=E1BGW5	Uncharacterized protein	ISS	10441327	PubMed	PTHR12346:SF1	PAIRED AMPHIPATHIC HELIX PROTEIN SIN3B
P00048	PI3 kinase pathway	P01181	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00019	Endothelin signaling pathway	P00567	PKG	PANTR|Ensembl=ENSPTRG00000016212|UniProtKB=H2QPS4	cGMP-dependent protein kinase	ISS	12775716	PubMed	PTHR24353:SF24	SUBFAMILY NOT NAMED
P05730	Endogenous cannabinoid signaling	P05746	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00005	Angiogenesis	P00214	HIF-1	HUMAN|HGNC=4910|UniProtKB=Q16665	Hypoxia-inducible factor 1-alpha	IGI	14526383	PubMed	PTHR23043:SF7	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA
P00018	EGF receptor signaling pathway	P00547	PP2A	HUMAN|HGNC=9300|UniProtKB=P62714	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	NAS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00015	Circadian clock system	G01501	cry	BOVIN|Ensembl=ENSBTAG00000021223|UniProtKB=F1N0J9	Uncharacterized protein	ISS	14507900	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	IPI	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00013	Cell cycle	P00480	Proteasome	BOVIN|Ensembl=ENSBTAG00000006101|UniProtKB=Q58DA0	26S proteasome non-ATPase regulatory subunit 4	ISS	10505793	PubMed	PTHR10223:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4
P00005	Angiogenesis	P00181	SHP2	PANTR|Ensembl=ENSPTRG00000042397|UniProtKB=H2RIH8	Tyrosine-protein phosphatase non-receptor type	ISS	8096088	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00021	FGF signaling pathway	P00623	FGF	CANLF|Ensembl=ENSCAFG00000016903|UniProtKB=E2RTC7	Fibroblast growth factor	ISS	12738892	PubMed	PTHR11486:SF4	FIBROBLAST GROWTH FACTOR 18
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00019	Endothelin signaling pathway	P00566	ERK	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MONDO|Ensembl=ENSMODG00000020977|UniProtKB=F6S5B1	Uncharacterized protein (Fragment)	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00778	NMDA receptor	MOUSE|MGI=MGI=2150393|UniProtKB=Q91ZU9	Glutamate receptor ionotropic, NMDA 3B	IDA	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	10218114	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00034	Integrin signalling pathway	P00948	Rho	BOVIN|Ensembl=ENSBTAG00000018773|UniProtKB=Q2HJ68	Rho-related GTP-binding protein Rho6	ISS	11973360	PubMed	PTHR24072:SF23	RHO-RELATED GTP-BINDING PROTEIN RHO6
P00059	p53 pathway	P01486	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00053	T cell activation	P01307	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00012	Cadherin signaling pathway	P00470	F-actin	DICDI|dictyBase=DDB_G0268744|UniProtKB=Q55EU6	Putative actin-23	IC	10974003	PubMed	PTHR11937:SF154	ACTIN-17-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	HUMAN|HGNC=4579|UniProtKB=P39086	Glutamate receptor ionotropic, kainate 1	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	RAT|RGD=1304575|UniProtKB=B5DF98	Map3k3 protein	ISS	8649450	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	ARATH|TAIR=AT5G07880|UniProtKB=Q9SD96	SNAP25 homologous protein SNAP29	IC			PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00029	Huntington disease	P00790	beta-Tubulin	XENTR|Xenbase=XB-GENE-491459|UniProtKB=L7N3Q3	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00030	Hypoxia response via HIF activation	P00819	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	TAS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00470	F-actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347736|UniProtKB=E9FRT1	Muscle-specific actin	ISS	10974003	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00005	Angiogenesis	P00206	Wnt	CHICK|Ensembl=ENSGALG00000005123|UniProtKB=Q9DEB8	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00059	p53 pathway	G01572	NOXA	MOUSE|MGI=MGI=1918611|UniProtKB=Q8BUE4	Apoptosis-inducing factor 2	ISS			PTHR43735:SF9	APOPTOSIS-INDUCING FACTOR 2
P00029	Huntington disease	P00798	Clathrin	RAT|RGD=621353|UniProtKB=P08082	Clathrin light chain B	ISS	11889126	PubMed	PTHR10639:SF2	CLATHRIN LIGHT CHAIN B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00025	Hedgehog signaling pathway	P00692	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DANRE|ZFIN=ZDB-GENE-030131-55|UniProtKB=Q6XNL8	Actin	ISS	11889126	PubMed	PTHR11937:SF263	ACTIN
P00045	Notch signaling pathway	P01119	NIct	CANLF|Ensembl=ENSCAFG00000010476|UniProtKB=F1PS94	Uncharacterized protein	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000012777|UniProtKB=F7EIF1	Uncharacterized protein	ISS	8120095	PubMed	PTHR43912:SF1	PROTOCADHERIN-11 X-LINKED-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=88399|UniProtKB=P32211	Muscarinic acetylcholine receptor M4	IDA	12181435	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00778	NMDA receptor	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	IDA	14698601	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00010	B cell activation	P00381	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	IC	91298951	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P05916	Opioid prodynorphin pathway	P06002	G-protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01151	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	DROME|FlyBase=FBgn0040508|UniProtKB=Q9VK53	ACXC, isoform A	ISS			PTHR11920:SF338	ACXA, ISOFORM A-RELATED
P00053	T cell activation	P01307	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00057	Wnt signaling pathway	P01456	beta-arrestin	RAT|RGD=2157|UniProtKB=P29067	Beta-arrestin-2	IDA	11742073	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00053	T cell activation	P01336	Jnk	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00029	Huntington disease	P00777	CBP	HUMAN|HGNC=3373|UniProtKB=Q09472	Histone acetyltransferase p300	IDA	8413673	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00057	Wnt signaling pathway	P01428	Frizzled	DANRE|ZFIN=ZDB-GENE-000328-3|UniProtKB=Q9YI00	Frizzled 8a protein	IDA	8717036	PubMed	PTHR11309:SF90	FRIZZLED-8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00057	Wnt signaling pathway	P01446	Calcineurin	DROME|FlyBase=FBgn0010014|UniProtKB=P48451	Calcineurin subunit B type 1	IDA	12015605	PubMed	PTHR23056:SF4	PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1
P00029	Huntington disease	P00807	Actin	XENTR|Xenbase=XB-GENE-490883|UniProtKB=Q6NVA9	Actin, cytoplasmic 1	ISS	11889139	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P05730	Endogenous cannabinoid signaling	P05743	CB1	ORNAN|Ensembl=ENSOANG00000000534|UniProtKB=F7CUB0	Uncharacterized protein	ISS	114610	OMIM	PTHR22750:SF47	CANNABINOID RECEPTOR 1
P05734	Synaptic vesicle trafficking	P05779	Synaptobrevin	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IDA	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	XENTR|Xenbase=XB-GENE-966302|UniProtKB=F6T2E7	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00013	Cell cycle	P00489	CdkC	CAEEL|WormBase=WBGene00009650|UniProtKB=O17869	CyCliN K	ISS			PTHR10026:SF51	CYCLIN-K
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00010	B cell activation	P00376	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04393	Ras Pathway	P04568	MKK3/6	ORNAN|Ensembl=ENSOANG00000007732|UniProtKB=F6PXH5	Uncharacterized protein (Fragment)	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01312	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	BOVIN|Gene=CTNNA1|UniProtKB=Q3MHM6	Catenin alpha-1	ISS	1904011	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00059	p53 pathway	G01581	BAX	MACMU|Ensembl=ENSMMUG00000003907|UniProtKB=F6ZV96	Apoptosis regulator BAX isoform alpha	ISS	11099028	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	IPI	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00551	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00557	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IGI	14526383	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00036	Interleukin signaling pathway	P00981	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	TAS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00021	FGF signaling pathway	P00638	PLCgamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00021	FGF signaling pathway	P00627	ERK1-2	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00018	EGF receptor signaling pathway	P00565	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	PANTR|Ensembl=ENSPTRG00000016293|UniProtKB=H2QPW8	Serine/threonine-protein kinase receptor	ISS	10683140	PubMed	PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P00034	Integrin signalling pathway	P00951	Jnk	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IDA	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CHICK|Ensembl=ENSGALG00000006576|UniProtKB=E1BUE5	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	RAT|RGD=619965|UniProtKB=P26769	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00029	Huntington disease	P00779	TBP	DICDI|dictyBase=DDB_G0275617|UniProtKB=P26355	TATA-box-binding protein	IPI	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P02763	Peptidoglycan biosynthesis	P03088	UDP-N-acetylmuramate dehydrogenase	CHLTR|EnsemblGenome=CT_831|UniProtKB=P0CD77	UDP-N-acetylenolpyruvoylglucosamine reductase	ISS			PTHR21071:SF4	UDP-N-ACETYLENOLPYRUVOYLGLUCOSAMINE REDUCTASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	BOVIN|Ensembl=ENSBTAG00000014674|UniProtKB=P41985	Muscarinic acetylcholine receptor M2	ISS	10069496	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	DAPPU|EnsemblGenome=DAPPUDRAFT_306746|UniProtKB=E9GYE9	Putative uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	MONDO|Ensembl=ENSMODG00000015573|UniProtKB=F7AIP6	Uncharacterized protein (Fragment)	ISS	11266476	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00029	Huntington disease	P00778	NMDA receptor	HUMAN|HGNC=4588|UniProtKB=O15399	Glutamate receptor ionotropic, NMDA 2D	IDA	11554549	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P02772	Pyruvate metabolism	P03141	Citrate Synthetase	NEUCR|EnsemblGenome=EFNCRG00000001885|UniProtKB=P34085	Citrate synthase, mitochondrial	NAS	11268307	gi	PTHR11739:SF8	CITRATE SYNTHASE, MITOCHONDRIAL
P00046	Oxidative stress response	P01125	Stat1	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	14755057	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	TAS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00866	Cytokine receptor	CHICK|Ensembl=ENSGALG00000015942|UniProtKB=F1P5Q0	Uncharacterized protein	IDA	12163451	PubMed	PTHR20859:SF54	INTERFERON ALPHA/BETA RECEPTOR 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	ISS	11956331	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	MACMU|Ensembl=ENSMMUG00000011773|UniProtKB=F7HQF4	Uncharacterized protein	ISS	12441358	PubMed	PTHR24247:SF31	5-HYDROXYTRYPTAMINE RECEPTOR 2B
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	IC	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00005	Angiogenesis	P00189	Fzd	MOUSE|MGI=MGI=108571|UniProtKB=Q9EQD0	Frizzled-5	ISS	11212302	PubMed	PTHR11309:SF126	FRIZZLED-5
P00037	Ionotropic glutamate receptor pathway	P01026	KA	CHICK|Ensembl=ENSGALG00000015835|UniProtKB=F1NZT2	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00005	Angiogenesis	P00236	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01171	PLCgamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00005	Angiogenesis	P00238	Ras	TAKRU|Ensembl=ENSTRUG00000005329|UniProtKB=H2SK54	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00011	Blood coagulation	P00418	Fibrin monomer	MOUSE|MGI=MGI=99501|UniProtKB=Q8K0E8	Fibrinogen beta chain	ISS	1706801	gi	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00010	B cell activation	P00402	Jnk	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IDA	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05916	Opioid prodynorphin pathway	P06002	G-protein	BOVIN|Ensembl=ENSBTAG00000006495|UniProtKB=P11017	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00057	Wnt signaling pathway	P01440	Cadherin	XENTR|Xenbase=XB-GENE-983603|UniProtKB=F6ZXH1	Uncharacterized protein	ISS	8120095	PubMed	PTHR43912:SF3	PROTOCADHERIN-1
P00054	Toll receptor signaling pathway	P01352	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04393	Ras Pathway	P04566	Stat 1/3	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	IDA	14984365	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00018	EGF receptor signaling pathway	P00550	Grb2	HUMAN|HGNC=4562|UniProtKB=Q13588	GRB2-related adapter protein	ISS	51702266	gi	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	9094314	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04397	p53 pathway by glucose deprivation	P04647	LKB1	HUMAN|HGNC=11389|UniProtKB=Q15831	Serine/threonine-protein kinase STK11	ISS			PTHR44214:SF1	SERINE/THREONINE-PROTEIN KINASE STK11
P00052	TGF-beta signaling pathway	P01275	P38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	TAS	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00001	Adrenaline and noradrenaline biosynthesis	P00061	PNMT	CAEEL|WormBase=WBGene00018340|UniProtKB=Q20308	Amine N-MethylTransferase	ISS			PTHR10867:SF30	AMINE N-METHYLTRANSFERASE
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	PANTR|Ensembl=ENSPTRG00000022245|UniProtKB=H2QZ29	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00016	Cytoskeletal regulation by Rho GTPase	P00514	MLCK	HUMAN|HGNC=7590|UniProtKB=Q15746	Myosin light chain kinase, smooth muscle	TAS	11157482	PubMed	PTHR45480:SF1	MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE
P00057	Wnt signaling pathway	P01455	Smad4	RAT|RGD=3030|UniProtKB=P97588	Mothers against decapentaplegic homolog 1	IDA	12736218	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00047	PDGF signaling pathway	P01162	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00777	CBP	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	IDA	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DANRE|ZFIN=ZDB-GENE-000329-3|UniProtKB=Q7ZVF9	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00047	PDGF signaling pathway	P01143	ERK	RAT|RGD=628675|UniProtKB=Q9Z2A6	Mitogen-activated protein kinase 15	ISS	10514528	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00057	Wnt signaling pathway	P01457	GBeta	DROME|FlyBase=FBgn0004623|UniProtKB=P29829	Guanine nucleotide-binding protein subunit beta-2	ISS	10391901	PubMed	PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00056	VEGF signaling pathway	P01425	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00023	General transcription regulation	P00658	TBP-associated factors	ARATH|TAIR=AT3G02160|UniProtKB=Q9S7R9	At3g02160	ISS	604903	OMIM	PTHR12321:SF53	BROMODOMAIN TRANSCRIPTION FACTOR
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P06664	Gonadotropin-releasing hormone receptor pathway	P06710	Junc	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	RCA	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	ARATH|TAIR=AT1G50360|UniProtKB=F4I507	Myosin-3	IC			PTHR13140:SF685	MYOSIN-1-RELATED
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00029	Huntington disease	P00807	Actin	PANTR|Ensembl=ENSPTRG00000009762|UniProtKB=H2QE24	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MOUSE|MGI=MGI=1309999|UniProtKB=Q922R0	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00702	CPB	PANTR|Ensembl=ENSPTRG00000001368|UniProtKB=H2Q045	Uncharacterized protein	ISS			PTHR22952:SF105	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 4
P00036	Interleukin signaling pathway	P00965	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00221	JNK1	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00048	PI3 kinase pathway	P01192	p110	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04397	p53 pathway by glucose deprivation	P04636	S6K	PANTR|Ensembl=ENSPTRG00000009477|UniProtKB=H2QDK7	Ribosomal protein S6 kinase	ISS	15116068	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00049	Parkinson disease	P01211	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	21150461	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05730	Endogenous cannabinoid signaling	P05746	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00053	T cell activation	P01309	fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	TAS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	ISS	12805548	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04393	Ras Pathway	P04565	MKK4/7	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	ISS	176910	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00049	Parkinson disease	P01219	SAPK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00034	Integrin signalling pathway	P00947	Laminin	PANTR|Ensembl=ENSPTRG00000001762|UniProtKB=H2Q0R2	Laminin, gamma 2	ISS	2538453	PubMed	PTHR10574:SF313	LAMININ SUBUNIT GAMMA-2
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	IDA	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00006	Apoptosis signaling pathway	P00274	JNK	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04392	P53 pathway feedback loops 1	P04538	Pirh-2	RAT|RGD=1359180|UniProtKB=Q5XIE4	Protein Rchy1	ISS	607680	OMIM	PTHR21319:SF20	RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00322	Cytochrome C	CHICK|Ensembl=ENSGALG00000011020|UniProtKB=P67881	Cytochrome c	ISS			PTHR11961:SF12	CYTOCHROME C
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00006	Apoptosis signaling pathway	P00271	Bax	HUMAN|HGNC=959|UniProtKB=Q07812	Apoptosis regulator BAX	ISS	14963330	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P02747	Histidine biosynthesis	P02984	Imidazol glycerol phosphate dehydratase	SCHPO|PomBase=SPBC21H7.07c|UniProtKB=P40374	Imidazoleglycerol-phosphate dehydratase	ISS			PTHR23133:SF2	IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	HUMAN|HGNC=7852|UniProtKB=O00746	Nucleoside diphosphate kinase, mitochondrial	ISS			PTHR11349:SF49	NUCLEOSIDE DIPHOSPHATE KINASE, MITOCHONDRIAL
P00005	Angiogenesis	P00207	Crk	RAT|RGD=2405|UniProtKB=Q63768	Adapter molecule crk	ISS	8649368	PubMed	PTHR19969:SF8	ADAPTER MOLECULE CRK
P00059	p53 pathway	P01480	PTEN	CAEEL|WormBase=WBGene00000913|UniProtKB=G5EE01	DAF-18	ISS	9885576	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000000365|UniProtKB=F6R9F4	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P05916	Opioid prodynorphin pathway	P06002	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	8170357	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04398	p53 pathway feedback loops 2	P04657	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00054	Toll receptor signaling pathway	P01369	MKK1	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_58093|UniProtKB=C3Z4K3	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00005	Angiogenesis	P00231	HSP27	DANRE|ZFIN=ZDB-GENE-020508-1|UniProtKB=Q8UUZ6	Alpha A crystallin	ISS			PTHR11527:SF36	ALPHA-CRYSTALLIN A CHAIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CAEEL|WormBase=WBGene00006372|UniProtKB=Q20574	Putative syntaxin-2	IC			PTHR19957:SF113	SYNTAXIN-2-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	IDA	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00029	Huntington disease	P00790	beta-Tubulin	CANLF|Ensembl=ENSCAFG00000000443|UniProtKB=E2QSF4	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00004	Alzheimer disease-presenilin pathway	P00165	E-cadherin N-terminal fragment	XENTR|Xenbase=XB-GENE-482277|UniProtKB=F6QAX3	Uncharacterized protein	ISS	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	TAS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000009871|UniProtKB=H2QE95	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	CHLTR|EnsemblGenome=CT_183|UniProtKB=Q59321	CTP synthase	ISS			PTHR11550:SF0	CTP SYNTHASE
P00025	Hedgehog signaling pathway	P00688	Hedgehog	HUMAN|HGNC=10848|UniProtKB=Q15465	Sonic hedgehog protein	IDA	8896571	PubMed	PTHR11889:SF36	SONIC HEDGEHOG PROTEIN
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	ISS	176892	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	MONDO|Ensembl=ENSMODG00000011857|UniProtKB=F7GDB2	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF76	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=621025|UniProtKB=Q62711	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	10934033	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	ARATH|TAIR=AT5G58670|UniProtKB=Q39032	Phosphoinositide phospholipase C 1	ISS			PTHR10336:SF105	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE
P00001	Adrenaline and noradrenaline biosynthesis	P00067	MAO	PANTR|Ensembl=ENSPTRG00000021816|UniProtKB=H2QYH5	Amine oxidase [flavin-containing]	ISS	90344230	PubMed	PTHR43563:SF3	AMINE OXIDASE  FLAVIN-CONTAINING  A
P05918	p38 MAPK pathway	P06044	GADD45	MACMU|Ensembl=ENSMMUG00000014808|UniProtKB=F6W540	Growth arrest and DNA damage-inducible protein GADD45 alpha isoform 1	ISS	9827804	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P05915	Opioid proenkephalin pathway	P05987	peptide F	MACMU|Ensembl=ENSMMUG00000006775|UniProtKB=F7H3N8	Uncharacterized protein	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00059	p53 pathway	P04623	CBP	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	MOUSE|MGI=MGI=1916603|UniProtKB=Q9D2A5	Cyclic AMP-responsive element-binding protein 3-like protein 4	ISS	608986	OMIM	PTHR22952:SF105	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 4
P04398	p53 pathway feedback loops 2	P04668	p53	CHICK|Ensembl=ENSGALG00000007324|UniProtKB=F1N8Z7	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00036	Interleukin signaling pathway	P00973	PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02771	Pyrimidine Metabolism	P03126	Nucleoside Phosphorylase	STRCO|Gene=CAC33055|UniProtKB=Q9AK36	Thymidine phosphorylase	ISS	12000953	PubMed	PTHR10515:SF0	THYMIDINE PHOSPHORYLASE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00053	T cell activation	P01307	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	IPI	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04393	Ras Pathway	P04541	p90RSK	MOUSE|MGI=MGI=104557|UniProtKB=P18654	Ribosomal protein S6 kinase alpha-3	IDA	2779569	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P04398	p53 pathway feedback loops 2	P04663	Mdm2	PANTR|Ensembl=ENSPTRG00000001889|UniProtKB=H2R875	Mdm4 p53 binding protein homolog	ISS			PTHR13844:SF20	PROTEIN MDM4
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	PANTR|Ensembl=ENSPTRG00000015241|UniProtKB=Q5IS72	D(3) dopamine receptor	ISS	2137198	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00010	B cell activation	P00373	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IGI	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	DANRE|ZFIN=ZDB-GENE-030407-1|UniProtKB=F1QC27	Uncharacterized protein	ISS			PTHR11681:SF14	SUBFAMILY NOT NAMED
P00029	Huntington disease	G01535	PIG3	RAT|RGD=1311639|UniProtKB=Q6AYT0	Quinone oxidoreductase	ISS	12932731	PubMed	PTHR44154:SF1	QUINONE OXIDOREDUCTASE
P00017	DNA replication	P00538	RNase H	PYRAE|EnsemblGenome=PAE1216|UniProtKB=Q8ZXL6	Ribonuclease HII	ISS	21664397	PubMed	PTHR10954:SF7	RIBONUCLEASE H2 SUBUNIT A
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	ARATH|TAIR=AT2G31300|UniProtKB=Q9SJW6	Actin-related protein 2/3 complex subunit 1B	ISS	12932731	PubMed	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P00018	EGF receptor signaling pathway	P00565	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	IGI	10395542	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00021	FGF signaling pathway	P00633	Ras	DANRE|ZFIN=ZDB-GENE-990415-166|UniProtKB=P79737	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00012	Cadherin signaling pathway	P00470	F-actin	PLAF7|EnsemblGenome=PFL2215w|UniProtKB=Q8I4X0	Actin-1	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	RAT|RGD=3694|UniProtKB=Q01827	Synaptic vesicular amine transporter	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	IDA	11707292	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01205	NOS	CANLF|Gene=NOS3|UniProtKB=Q9TUX8	Nitric oxide synthase, endothelial	ISS	93055452	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00019	Endothelin signaling pathway	P00570	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PANTR|Ensembl=ENSPTRG00000023562|UniProtKB=H2R1F1	Myosin VA (Heavy chain 12, myoxin)	ISS			PTHR13140:SF273	UNCONVENTIONAL MYOSIN-VA
P00045	Notch signaling pathway	P01110	Presenilin	DROME|FlyBase=FBgn0019947|UniProtKB=O02194	Presenilin homolog	TAS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00034	Integrin signalling pathway	P00912	Arp2/3	CHICK|Ensembl=ENSGALG00000004693|UniProtKB=Q5ZJI7	Uncharacterized protein	ISS	12932731	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00029	Huntington disease	P00778	NMDA receptor	MOUSE|MGI=MGI=1933206|UniProtKB=A2AIR5	Protein Grin3a	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P05912	Dopamine receptor mediated signaling pathway	P05960	VAT2	MACMU|Ensembl=ENSMMUG00000014817|UniProtKB=F6VXD8	Uncharacterized protein	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00036	Interleukin signaling pathway	P00990	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00941	Integrin alpha	ANOGA|EnsemblGenome=AGAP004303|UniProtKB=Q7QAC8	AGAP004303-PA	IPI	3487386	PubMed	PTHR23220:SF83	INTEGRIN ALPHA-PS3-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=107469|UniProtKB=Q8K3R3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	12860966	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P02744	Fructose galactose metabolism	P02963	Ketohexokinase	PANTR|Ensembl=ENSPTRG00000011746|UniProtKB=H2QHL3	Uncharacterized protein	ISS	9799106	PubMed	PTHR43085:SF1	KETOHEXOKINASE
P00014	Cholesterol biosynthesis	P00499	Farnesyl-diphosphate farnesyltransferase	CANLF|Ensembl=ENSCAFG00000007948|UniProtKB=E2R6N6	Uncharacterized protein	ISS			PTHR11626:SF2	SQUALENE SYNTHASE
P00057	Wnt signaling pathway	P01451	Galpha	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	IDA	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	HUMAN|HGNC=1885|UniProtKB=P01215	Glycoprotein hormones alpha chain	ISS	1099091	PubMed	PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P00023	General transcription regulation	P00670	TBP	MOUSE|MGI=MGI=1339946|UniProtKB=P62340	TATA box-binding protein-like protein 1	ISS	10082669	PubMed	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00047	PDGF signaling pathway	P01143	ERK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00021	FGF signaling pathway	P00632	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	DROME|FlyBase=FBgn0019985|UniProtKB=P91685	Metabotropic glutamate receptor	IDA	12488551	PubMed	PTHR24060:SF137	METABOTROPIC GLUTAMATE RECEPTOR
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IDA	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=109356|UniProtKB=O09044	Synaptosomal-associated protein 23	IC	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00018	EGF receptor signaling pathway	P00547	PP2A	MONDO|Ensembl=ENSMODG00000014177|UniProtKB=F6U7A6	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000002016|UniProtKB=F1P3G1	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00272	ASK1	MACMU|Ensembl=ENSMMUG00000016376|UniProtKB=F7G2W1	Uncharacterized protein	ISS	11730323	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00053	T cell activation	P01300	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02751	Lysine biosynthesis	P03008	Dihydrodipicolinate synthase	STRCO|Gene=CAB46390|UniProtKB=Q9X9Y3	Putative dihydropicolinate synthase	ISS			PTHR12128:SF19	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8671|UniProtKB=Q9Y5H7	Protocadherin alpha-5	IDA	8120095	PubMed	PTHR24028:SF111	PROTOCADHERIN ALPHA-5
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01311	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	RCA	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00010	B cell activation	P00386	Calcineurin	BOVIN|Ensembl=ENSBTAG00000016005|UniProtKB=P48452	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	IDA	12015605	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	ARATH|TAIR=AT1G13890|UniProtKB=Q9LMG8	Putative SNAP25 homologous protein SNAP30	IC			PTHR19305:SF7	SNAP25 HOMOLOGOUS PROTEIN SNAP30-RELATED
P00011	Blood coagulation	P00439	Prekallikrein	HUMAN|HGNC=6371|UniProtKB=P03952	Plasma kallikrein	ISS	4504877	gi	PTHR44459:SF2	PLASMA KALLIKREIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4404|UniProtKB=P59768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	XENTR|Xenbase=XB-GENE-490883|UniProtKB=Q6NVA9	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00577	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IGI	12660731	PubMed	PTHR10048:SF14	PI-3 KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CHICK|Ensembl=ENSGALG00000012511|UniProtKB=F1NCH1	Uncharacterized protein	ISS			PTHR11824:SF7	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4
P00006	Apoptosis signaling pathway	P00260	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IDA	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00507	Rho	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g243859|UniProtKB=A7S9Y5	Predicted protein	ISS	11973360	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00057	Wnt signaling pathway	P01446	Calcineurin	CHICK|Ensembl=ENSGALG00000005243|UniProtKB=E1C2T7	Serine/threonine-protein phosphatase	ISS	7532676	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IDA	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	HUMAN|HGNC=9299|UniProtKB=P67775	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00401	jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00638	PLCgamma	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00034	Integrin signalling pathway	P00931	Integrin beta	HUMAN|HGNC=6161|UniProtKB=P18564	Integrin beta-6	IDA	3487386	PubMed	PTHR10082:SF11	INTEGRIN BETA-6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	RAT|RGD=620859|UniProtKB=O70239	Axin-1	IEP	9554852	PubMed	PTHR10845:SF11	AXIN-1
P00053	T cell activation	P01336	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05918	p38 MAPK pathway	P05920	MAPKAP-K2	BOVIN|Ensembl=ENSBTAG00000038107|UniProtKB=F1MCX5	Uncharacterized protein	ISS	9628873	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00049	Parkinson disease	P01240	hSel10	RAT|RGD=1309121|UniProtKB=A0A0G2JVE0	Protein Fbxw11	ISS			PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	12488551	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DANRE|ZFIN=ZDB-GENE-030131-8225|UniProtKB=Q7SZZ5	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	CHICK|Ensembl=ENSGALG00000006197|UniProtKB=P21868	Casein kinase II subunit alpha	IDA	10617630	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00056	VEGF signaling pathway	P01423	p38MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00566	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	TAS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P06959	CCKR signaling map	P07188	RHOA-GTP	HUMAN|HGNC=667|UniProtKB=P61586	Transforming protein RhoA	RCA	12105855	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	CANLF|Ensembl=ENSCAFG00000013148|UniProtKB=Q5R1P3	Glutamate receptor ionotropic, NMDA 2B	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MOUSE|MGI=MGI=108571|UniProtKB=Q9EQD0	Frizzled-5	TAS	11212302	PubMed	PTHR11309:SF126	FRIZZLED-5
P00018	EGF receptor signaling pathway	P00552	Ras	HUMAN|HGNC=7227|UniProtKB=O14807	Ras-related protein M-Ras	ISS			PTHR24070:SF268	RAS-RELATED PROTEIN M-RAS
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00012	Cadherin signaling pathway	P00464	Fyn	PANTR|Ensembl=ENSPTRG00000018511|UniProtKB=H2QTK7	Tyrosine-protein kinase	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00038	JAK/STAT signaling pathway	P01027	STAT	BOVIN|Gene=STAT5B|UniProtKB=Q9TUM3	Signal transducer and activator of transcription 5B	ISS	22320921	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	MACMU|Ensembl=ENSMMUG00000006702|UniProtKB=F7HJS7	Serine/threonine-protein kinase receptor	ISS			PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00047	PDGF signaling pathway	P01162	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IGI	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	8170357	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	15210700	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00005	Angiogenesis	P00187	beta catenin	TAKRU|Ensembl=ENSTRUG00000003520|UniProtKB=H2S791	Uncharacterized protein	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P00052	TGF-beta signaling pathway	P01275	P38	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	TAS	10995439	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=30035|UniProtKB=Q8WYR1	Phosphoinositide 3-kinase regulatory subunit 5	ISS	12507995	PubMed	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00012	Cadherin signaling pathway	P00463	betacatenin	MACMU|Ensembl=ENSMMUG00000014627|UniProtKB=F7GNE4	Catenin beta-1	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00046	Oxidative stress response	P01129	JNK1/2	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MOUSE|MGI=MGI=95821|UniProtKB=Q01097	Glutamate receptor ionotropic, NMDA 2B	IC	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00046	Oxidative stress response	P01129	JNK1/2	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00060	Ubiquitin proteasome pathway	P01490	E3	PANTR|Ensembl=ENSPTRG00000005425|UniProtKB=H2Q6U5	Uncharacterized protein	ISS			PTHR11254:SF352	UBIQUITIN-PROTEIN LIGASE E3B
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	MACMU|Ensembl=ENSMMUG00000017431|UniProtKB=F7HPP3	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P02738	De novo purine biosynthesis	P02908	Phosphoribosylamine glycine ligase	HUMAN|HGNC=4163|UniProtKB=P22102	Trifunctional purine biosynthetic protein adenosine-3	ISS			PTHR10520:SF10	TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3
P00048	PI3 kinase pathway	P01190	PDK1 ACT	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	9094314	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	XENTR|Xenbase=XB-GENE-491618|UniProtKB=Q6P378	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00018	EGF receptor signaling pathway	P00551	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	20855874	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05960	VAT2	BOVIN|Gene=SLC18A2|UniProtKB=Q27963	Synaptic vesicular amine transporter	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00047	PDGF signaling pathway	P01150	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02786	Vitamin B6 biosynthesis	P03225	1-Deoxyxylulose-5-phosphate synthase	CHLRE|EnsemblGenome=CHLREDRAFT_196568|UniProtKB=A8JFW4	1-deoxy-D-xylulose 5-phosphate synthase (Fragment)	ISS			PTHR43322:SF5	1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE 1-RELATED
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01444	Wnt	ANOGA|EnsemblGenome=AGAP009734|UniProtKB=Q5TP56	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008422|UniProtKB=F6VUT7	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=1563261|UniProtKB=D4A4I3	Protein Pik3r5	ISS			PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00049	Parkinson disease	P01226	CDCrel-1	BOVIN|Gene=SEPT5|UniProtKB=Q0VC68	Septin-5	ISS	11078524	PubMed	PTHR18884:SF68	SEPTIN-5
P00018	EGF receptor signaling pathway	P00562	p38	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	SCHPO|PomBase=SPBC32H8.07|UniProtKB=Q10282	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00025	Hedgehog signaling pathway	P00692	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IGI	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	ORYSJ|EnsemblGenome=OS07G0495100|UniProtKB=Q84RS4	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_94959|UniProtKB=C3XYC4	Putative uncharacterized protein	IDA	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	HUMAN|HGNC=14250|UniProtKB=Q9H306	Matrix metalloproteinase-27	TAS	12834808	PubMed	PTHR10201:SF115	MATRIX METALLOPROTEINASE-27
P00034	Integrin signalling pathway	P00910	Grb2	DANRE|ZFIN=ZDB-GENE-040426-1975|UniProtKB=Q6PC73	Growth factor receptor-bound protein 2	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P02758	Ornithine degradation	P03055	Aminobutyraldehyde dehydrogenase	GLOVI|Gene=BAC90148|UniProtKB=Q7NIH6	Gll2207 protein	ISS			PTHR43104:SF2	L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00828	Galphai	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	RCA			PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01275	P38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00221	JNK1	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	DROME|FlyBase=FBgn0001291|UniProtKB=P18289	Transcription factor AP-1	TAS	10664585	PubMed	PTHR11462:SF35	TRANSCRIPTION FACTOR AP-1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9063|UniProtKB=Q15111	Inactive phospholipase C-like protein 1	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00018	EGF receptor signaling pathway	P00564	Rac	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS	12874273	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00551	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02749	Leucine biosynthesis	P03002	Isopropylmalate isomerase	METAC|EnsemblGenome=MA_3085|UniProtKB=Q8TLF1	Probable methanogen homoaconitase large subunit	ISS			PTHR43822:SF4	SUBFAMILY NOT NAMED
P04395	Vasopressin synthesis	P04597	Signal Peptide	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P02728	Arginine biosynthesis	P02841	argininosuccinate lyase	ARATH|TAIR=AT5G10920|UniProtKB=Q9LEU8	Argininosuccinate lyase, chloroplastic	ISS			PTHR43814:SF1	ARGININOSUCCINATE LYASE
P00036	Interleukin signaling pathway	P00970	Interleukin	CANLF|Ensembl=ENSCAFG00000004008|UniProtKB=Q29416	Interleukin-2	ISS	7622066	PubMed	PTHR45426:SF1	INTERLEUKIN-2
P00049	Parkinson disease	P01215	Syntaxin	MACMU|Ensembl=ENSMMUG00000012252|UniProtKB=F7GMG0	Syntaxin-12	ISS	14570579	PubMed	PTHR19957:SF88	SYNTAXIN-12
P00009	Axon guidance mediated by netrin	P00366	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	10540223	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00034	Integrin signalling pathway	P00916	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00054	Toll receptor signaling pathway	P01369	MKK1	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00021	FGF signaling pathway	P00641	SOS	DROME|FlyBase=FBgn0001965|UniProtKB=P26675	Protein son of sevenless	ISS	476780	gi	PTHR23113:SF99	PROTEIN SON OF SEVENLESS
P04398	p53 pathway feedback loops 2	P04657	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01335	jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00038	JAK/STAT signaling pathway	P01027	STAT	BOVIN|Gene=STAT5B|UniProtKB=Q9TUM3	Signal transducer and activator of transcription 5B	ISS	96210005	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00010	B cell activation	P00379	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02736	Coenzyme A biosynthesis	P02883	Pantothenoylcysteine decarboxylase	ARATH|TAIR=AT3G18030|UniProtKB=Q9SWE5	Phosphopantothenoylcysteine decarboxylase	ISS			PTHR14359:SF6	PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE
P00019	Endothelin signaling pathway	P00566	ERK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	NAS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00057	Wnt signaling pathway	P01444	Wnt	BOVIN|Ensembl=ENSBTAG00000001668|UniProtKB=F1N6L8	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P04398	p53 pathway feedback loops 2	P04665	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02740	De novo pyrimidine ribonucleotides biosythesis	P02927	Dihydrooratate oxidase	SYNY3|EnsemblGenome=BAA18627|UniProtKB=P74782	Dihydroorotate dehydrogenase (quinone)	ISS			PTHR43517:SF1	DIHYDROOROTATE DEHYDROGENASE  QUINONE , MITOCHONDRIAL
P00020	FAS signaling pathway	P00615	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01174	Rho	HUMAN|HGNC=14130|UniProtKB=Q9BRR9	Rho GTPase-activating protein 9	ISS	8288572	PubMed	PTHR23181:SF4	RHO GTPASE-ACTIVATING PROTEIN 9
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00047	PDGF signaling pathway	P01173	STAT	TAKRU|Ensembl=ENSTRUG00000015348|UniProtKB=H2UQK9	Signal transducer and activator of transcription	ISS	15452141	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00048	PI3 kinase pathway	P01192	p110	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	IC	15621031	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00059	p53 pathway	P04626	GADD45	MACMU|Ensembl=ENSMMUG00000014808|UniProtKB=F6W540	Growth arrest and DNA damage-inducible protein GADD45 alpha isoform 1	ISS	10097101	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P06664	Gonadotropin-releasing hormone receptor pathway	P06753	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	RCA	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P05731	GABA-B receptor II signaling	P05760	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	RCA	8557110	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MOUSE|MGI=MGI=104557|UniProtKB=P18654	Ribosomal protein S6 kinase alpha-3	ISS	10480933	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00048	PI3 kinase pathway	P01185	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00005	Angiogenesis	P00227	PLA2	PANTR|Ensembl=ENSPTRG00000001787|UniProtKB=H2Q0T0	Phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT2G43790|UniProtKB=Q39026	Mitogen-activated protein kinase 6	IDA			PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008026|UniProtKB=H2QAZ2	Syntaxin 1B	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IGI	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P06587	Nicotine pharmacodynamics pathway	P06593	CHRNA5	BOVIN|Ensembl=ENSBTAG00000013657|UniProtKB=Q8SPU7	Neuronal acetylcholine receptor subunit alpha-5	ISS	85270494	PubMed	PTHR18945:SF76	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5
P00029	Huntington disease	P00774	Dynein complex	PANTR|Ensembl=ENSPTRG00000018129|UniProtKB=H2QZX0	Uncharacterized protein	ISS	9454836	PubMed	PTHR10676:SF344	DYNEIN HEAVY CHAIN 8, AXONEMAL
P05913	Enkephalin release	P05974	G-Protein (i)	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00029	Huntington disease	P00807	Actin	CHLRE|EnsemblGenome=CHLREDRAFT_24392|UniProtKB=A8JAV1	Actin	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00021	FGF signaling pathway	P00627	ERK1-2	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	IGI	9836510	gi	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	ORNAN|Ensembl=ENSOANG00000006811|UniProtKB=F6WBD5	Uncharacterized protein	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00029	Huntington disease	G01535	PIG3	STRCO|Gene=CAB65629|UniProtKB=Q9RCW3	Putative oxidoreductase	TAS			PTHR43482:SF1	RETICULON-4-INTERACTING PROTEIN 1 HOMOLOG, MITOCHONDRIAL
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	IDA	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	PANTR|Ensembl=ENSPTRG00000020589|UniProtKB=H2QWQ6	Uncharacterized protein	ISS	12890691	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	MYCTU|EnsemblGenome=Rv1843c|UniProtKB=P9WKI3	Uncharacterized oxidoreductase Rv1843c	ISS			PTHR43170:SF4	GMP REDUCTASE 2
P00057	Wnt signaling pathway	P01440	Cadherin	CHICK|Ensembl=ENSGALG00000012941|UniProtKB=E1C235	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF96	CADHERIN-12
P00047	PDGF signaling pathway	P01163	c-Jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00011	Blood coagulation	P00448	vWF	PANTR|Ensembl=ENSPTRG00000004566|UniProtKB=H2Q597	Uncharacterized protein	ISS	193400	OMIM	PTHR11339:SF361	VON WILLEBRAND FACTOR-RELATED
P00059	p53 pathway	G04691	IGF-BP3	DANRE|ZFIN=ZDB-GENE-040412-1|UniProtKB=Q66I28	Insulin-like growth factor binding protein 3	ISS			PTHR11551:SF3	INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 3
P00036	Interleukin signaling pathway	P00994	FKHRL1	HUMAN|HGNC=3821|UniProtKB=O43524	Forkhead box protein O3	IC	10102273	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	IDA	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	ANOGA|EnsemblGenome=AGAP006718|UniProtKB=Q7QI86	AGAP006718-PA	ISS	94365697	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	HUMAN|HGNC=1388|UniProtKB=O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	IDA	15699344	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00053	T cell activation	P01306	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00029	Huntington disease	P00799	JNK-2	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P02783	Tryptophan biosynthesis	P03209	Anthranilate phosphoribosyl transferase	AQUAE|EnsemblGenome=aq_549|UniProtKB=O66825	Anthranilate synthase component II	ISS			PTHR43418:SF4	MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00048	PI3 kinase pathway	P01179	PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00859	NFkappaB	MOUSE|MGI=MGI=97312|UniProtKB=P25799	Nuclear factor NF-kappa-B p105 subunit	IDA	11739545	PubMed	PTHR24169:SF9	NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00188	Ets	ORNAN|Ensembl=ENSOANG00000012104|UniProtKB=F7FH70	Uncharacterized protein	ISS	3060801	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00021	FGF signaling pathway	P00632	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	TAS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00049	Parkinson disease	P01227	20S proteasome	MOUSE|MGI=MGI=1347006|UniProtKB=Q9QUM9	Proteasome subunit alpha type-6	TAS	12859888	PubMed	PTHR11599:SF11	PROTEASOME SUBUNIT ALPHA TYPE-6
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DROME|FlyBase=FBgn0000046|UniProtKB=P10981	Actin-87E	IDA	11889126	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00047	PDGF signaling pathway	P01154	Ras	CHICK|Ensembl=ENSGALG00000006885|UniProtKB=P08642	GTPase HRas	ISS	87226391	PubMed	PTHR24070:SF385	GTPASE HRAS
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DROME|FlyBase=FBgn0001105|UniProtKB=P26308	Guanine nucleotide-binding protein subunit beta-1	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00047	PDGF signaling pathway	P01145	c-fos	MONDO|Ensembl=ENSMODG00000018981|UniProtKB=F7FP88	Uncharacterized protein	ISS			PTHR11945:SF221	SERUM RESPONSE FACTOR
P00021	FGF signaling pathway	P00628	JNK1-3	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS			PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=620308|UniProtKB=P30936	Somatostatin receptor type 3	IDA	12181435	PubMed	PTHR24229:SF42	SOMATOSTATIN RECEPTOR TYPE 3
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00623	FGF	MACMU|Ensembl=ENSMMUG00000011744|UniProtKB=F7GWY6	Fibroblast growth factor	ISS	12851399	PubMed	PTHR11486:SF27	FIBROBLAST GROWTH FACTOR 16
P00057	Wnt signaling pathway	P01437	TCF	PANTR|Ensembl=ENSPTRG00000017236|UniProtKB=H2QRH6	Uncharacterized protein	ISS	12356903	PubMed	PTHR10373:SF33	TRANSCRIPTION FACTOR 7
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TAKRU|Ensembl=ENSTRUG00000014318|UniProtKB=H2UI49	Uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IDA	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	TAKRU|Ensembl=ENSTRUG00000001556|UniProtKB=H2RTU5	Uncharacterized protein (Fragment)	ISS			PTHR43893:SF11	SUBFAMILY NOT NAMED
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	SYNY3|EnsemblGenome=BAA16643|UniProtKB=P72641	Adenylate kinase 2	ISS			PTHR23359:SF22	GTP:AMP PHOSPHOTRANSFERASE, MITOCHONDRIAL
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	STRCO|Gene=CAC33054|UniProtKB=Q9AK37	Putative cytidine deaminase	ISS			PTHR11644:SF2	CYTIDINE DEAMINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	XENTR|Xenbase=XB-GENE-6067221|UniProtKB=F6Z0J4	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01440	Cadherin	BOVIN|Ensembl=ENSBTAG00000001739|UniProtKB=E1BAM8	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF84	CADHERIN-20
P00004	Alzheimer disease-presenilin pathway	P00113	Erb-B4 transmembrane fragment	CHICK|Ensembl=ENSGALG00000003126|UniProtKB=F1P258	Receptor protein-tyrosine kinase	ISS	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00018	EGF receptor signaling pathway	P00539	14-3-3	HUMAN|HGNC=12854|UniProtKB=P27348	14-3-3 protein theta	IGI	7603573	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P00016	Cytoskeletal regulation by Rho GTPase	P00519	ROCK	PANTR|Ensembl=ENSPTRG00000011658|UniProtKB=H2RCA0	Rho-associated protein kinase	ISS			PTHR22988:SF28	RHO-ASSOCIATED PROTEIN KINASE 2
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	PANTR|Ensembl=ENSPTRG00000010617|UniProtKB=H2QFL8	Notch 3	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MACMU|Ensembl=ENSMMUG00000012054|UniProtKB=F6TII3	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00029	Huntington disease	P00786	ARF	PANTR|Ensembl=ENSPTRG00000009244|UniProtKB=H2QD50	ADP-ribosylation factor-like 4D	ISS	12932731	PubMed	PTHR11711:SF137	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 4D
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00559	MEK1-2	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00019	Endothelin signaling pathway	P00566	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	CHICK|Ensembl=ENSGALG00000004796|UniProtKB=Q90694	Cell division control protein 42 homolog	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00034	Integrin signalling pathway	P00906	Rap1	DROME|FlyBase=FBgn0283666|UniProtKB=O96692	RE63021p	IC			PTHR24070:SF295	RE63021P
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=16265|UniProtKB=Q9H1J7	Protein Wnt-5b	IDA	11266476	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00004	Alzheimer disease-presenilin pathway	P00162	Pro-BACE-1	HUMAN|HGNC=933|UniProtKB=P56817	Beta-secretase 1	IDA	10956649	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00509	Slingshot	MOUSE|MGI=MGI=2679255|UniProtKB=Q5SW75	Protein phosphatase Slingshot homolog 2	ISS			PTHR10159:SF106	PROTEIN PHOSPHATASE SLINGSHOT HOMOLOG 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00045	Notch signaling pathway	G01541	E(spl)-C genes	HUMAN|HGNC=24149|UniProtKB=Q9HCC6	Transcription factor HES-4	TAS	14973298	PubMed	PTHR10985:SF125	TRANSCRIPTION FACTOR HES-4
P00034	Integrin signalling pathway	P00941	Integrin alpha	MOUSE|MGI=MGI=96606|UniProtKB=P24063	Integrin alpha-L	IPI	3487386	PubMed	PTHR23220:SF84	INTEGRIN ALPHA-L
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CAEBR|Gene=CBG07339|UniProtKB=A8X4Z4	Protein CBR-SYX-2	ISS			PTHR19957:SF113	SYNTAXIN-2-RELATED
P00005	Angiogenesis	P00205	GAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00021	FGF signaling pathway	P00640	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00051	TCA cycle	P01273	Succinate Dehydrogenase	BRADU|Gene=BAC45777|UniProtKB=H7C7T8	Succinate dehydrogenase cytochrome B-556 subunit	IDA	99350437	PubMed	PTHR10978:SF10	SUBFAMILY NOT NAMED
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00590	IP3 R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IGI	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00059	p53 pathway	G01579	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	IGI	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	TAKRU|Ensembl=ENSTRUG00000000002|UniProtKB=H2RIN9	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF236	SUBFAMILY NOT NAMED
P00010	B cell activation	P00375	Calmodulin	TRIAD|EnsemblGenome=TriadG37105|UniProtKB=B3RJX8	Calmodulin	ISS			PTHR23050:SF245	AT16150P-RELATED
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04387	Histamine synthesis	P04493	Histidine decarboxylase	MOUSE|MGI=MGI=96062|UniProtKB=P23738	Histidine decarboxylase	ISS	1702422	PubMed	PTHR11999:SF68	HISTIDINE DECARBOXYLASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05913	Enkephalin release	G06045	preproenkephalin	BOVIN|Gene=PDYN|UniProtKB=Q95104	Proenkephalin-B	IC	131330	OMIM	PTHR11438:SF4	PROENKEPHALIN-B
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	CHICK|Ensembl=ENSGALG00000009640|UniProtKB=F1P0I0	Muscarinic acetylcholine receptor	TAS	8100450	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2521|UniProtKB=P19020	D(3) dopamine receptor	IDA	1319557	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00054	Toll receptor signaling pathway	P01347	MD-2	MACMU|Ensembl=ENSMMUG00000003018|UniProtKB=B3Y6B1	Lymphocyte antigen 96	ISS			PTHR15218:SF0	LYMPHOCYTE ANTIGEN 96
P05913	Enkephalin release	P05972	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00021	FGF signaling pathway	P00623	FGF	DANRE|ZFIN=ZDB-GENE-050221-6|UniProtKB=Q5TKR3	Fibroblast growth factor	ISS	9232594	PubMed	PTHR11486:SF17	FIBROBLAST GROWTH FACTOR 12
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	HUMAN|HGNC=903|UniProtKB=O15169	Axin-1	IEP	9554852	PubMed	PTHR10845:SF11	AXIN-1
P00034	Integrin signalling pathway	P00925	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00557	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00034	Integrin signalling pathway	P00907	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	IDA	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00029	Huntington disease	P00805	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P06587	Nicotine pharmacodynamics pathway	P06606	ADCY2	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04393	Ras Pathway	P04542	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IDA	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00012	Cadherin signaling pathway	P00470	F-actin	CANLF|Ensembl=ENSCAFG00000015708|UniProtKB=F2Z4N0	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00048	PI3 kinase pathway	P01199	Galpha	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	HUMAN|HGNC=4572|UniProtKB=P42262	Glutamate receptor 2	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=619858|UniProtKB=P70579	Metabotropic glutamate receptor 8	IDA	9407094	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P05918	p38 MAPK pathway	P06015	p38gamma	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	RCA	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CIOIN|Ensembl=ENSCING00000007153|UniProtKB=L7N0T1	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00059	p53 pathway	G04694	p110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04398	p53 pathway feedback loops 2	P04652	E2F-1	DROME|FlyBase=FBgn0011766|UniProtKB=Q27368	Transcription factor E2f1	ISS	20196006	PubMed	PTHR12081:SF52	TRANSCRIPTION FACTOR E2F2-RELATED
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	CAEEL|WormBase=WBGene00001622|UniProtKB=Q22682	Putative sodium-dependent excitatory amino acid transporter glt-4	ISS	96032356	PubMed	PTHR11958:SF56	SODIUM-DEPENDENT EXCITATORY AMINO ACID TRANSPORTER GLT-4-RELATED
P00019	Endothelin signaling pathway	P00580	ET-RA/B	BOVIN|Ensembl=ENSBTAG00000013674|UniProtKB=P21450	Endothelin-1 receptor	IPI	91080923	PubMed	PTHR24243:SF31	ENDOTHELIN-1 RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	BOVIN|Gene=ARRB2|UniProtKB=P32120	Beta-arrestin-2	ISS	12464600	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P06210	Activin beta signaling pathway	P06233	MED	DROME|FlyBase=FBgn0011655|UniProtKB=O62609	Mothers against decapentaplegic homolog	IEA	http://flybase.org/reports/FBgn0011655.html	Website	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IDA	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00010	B cell activation	P00398	IP3R	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	IGI	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00048	PI3 kinase pathway	P01181	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	MACMU|Ensembl=ENSMMUG00000017022|UniProtKB=F7HQZ9	Uncharacterized protein	ISS	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00021	FGF signaling pathway	P00634	MEKK1-5	HUMAN|HGNC=6857|UniProtKB=Q99683	Mitogen-activated protein kinase kinase kinase 5	IGI	12697749	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	TRYB2|Gene=Tb927.7.5480|UniProtKB=Q582G3	Bifunctional dihydrofolate reductase-thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00018	EGF receptor signaling pathway	P00547	PP2A	HUMAN|HGNC=9310|UniProtKB=Q15173	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform	ISS	11531413	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00049	Parkinson disease	P01219	SAPK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00369	MEKK	BOVIN|Ensembl=ENSBTAG00000008151|UniProtKB=F1MH06	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	HUMAN|HGNC=17780|UniProtKB=Q562R1	Beta-actin-like protein 2	IC	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00005	Angiogenesis	P00221	JNK1	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00766	Htt	RAT|RGD=68337|UniProtKB=P51111	Huntingtin	IDA	9462744	PubMed	PTHR10170:SF10	HUNTINGTIN
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	PANTR|Ensembl=ENSPTRG00000015968|UniProtKB=H2R2Q6	Uncharacterized protein	ISS	12145413	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00046	Oxidative stress response	P01135	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT1G59580|UniProtKB=Q39022	Mitogen-activated protein kinase 2	ISS	11707292	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00057	Wnt signaling pathway	P01451	Galpha	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IDA	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00019	Endothelin signaling pathway	P00586	Gq	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	CANLF|Ensembl=ENSCAFG00000015081|UniProtKB=E2RMT4	Uncharacterized protein	ISS	12932731	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P05915	Opioid proenkephalin pathway	P05994	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	FUSNN|EnsemblGenome=FN0422|UniProtKB=Q8RG86	Carbamoyl-phosphate synthase large chain	ISS			PTHR11405:SF5	CAD PROTEIN
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	ARATH|TAIR=AT4G38530|UniProtKB=Q56W08	Phosphoinositide phospholipase C 3	ISS			PTHR10336:SF105	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	IGI	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00644	p38	CAEEL|WormBase=WBGene00004056|UniProtKB=Q8MXI4	Mitogen-activated protein kinase pmk-2	ISS	11274345	PubMed	PTHR24055:SF154	MITOGEN-ACTIVATED PROTEIN KINASE PMK-2
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	MOUSE|MGI=MGI=109367|UniProtKB=P24547	Inosine-5'-monophosphate dehydrogenase 2	ISS			PTHR11911:SF121	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2
P00047	PDGF signaling pathway	P01154	Ras	SCHPO|PomBase=SPAC17H9.09c|UniProtKB=P08647	Ras-like protein 1	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12805548	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=4401|UniProtKB=O14775	Guanine nucleotide-binding protein subunit beta-5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00059	p53 pathway	P01483	Mdm2	CANLF|Ensembl=ENSCAFG00000009669|UniProtKB=E2RDT3	Uncharacterized protein	ISS			PTHR13844:SF20	PROTEIN MDM4
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	HUMAN|HGNC=143|UniProtKB=P68032	Actin, alpha cardiac muscle 1	IEP	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	PANTR|Ensembl=ENSPTRG00000033819|UniProtKB=H2QV00	Actin related protein 2/3 complex, subunit 1A, 41kDa	ISS	12473693	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00057	Wnt signaling pathway	P01443	Phospholipase C	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00005	Angiogenesis	P00243	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00586	Gq	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IGI	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P06959	CCKR signaling map	P07237	GRB2	HUMAN|HGNC=4566|UniProtKB=P62993	Growth factor receptor-bound protein 2	RCA		PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00029	Huntington disease	P00785	Cytochrome c	IXOSC|EnsemblGenome=ISCW016731|UniProtKB=B7P8B3	Cytochrome c1, putative	ISS	9027315	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P04393	Ras Pathway	P04548	ATF2	CHICK|Ensembl=ENSGALG00000009287|UniProtKB=O93602	Cyclic AMP-dependent transcription factor ATF-2	IDA	11390664	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P05730	Endogenous cannabinoid signaling	P05751	Galpha	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CHICK|Ensembl=ENSGALG00000009405|UniProtKB=F1NKF1	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IDA	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	10218114	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00047	PDGF signaling pathway	P01161	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CAEBR|Gene=CBG23091|UniProtKB=A8Y4Q9	Protein CBR-ACT-2	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00010	B cell activation	P00379	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04393	Ras Pathway	P04567	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00038	JAK/STAT signaling pathway	P01031	PIAS	MOUSE|MGI=MGI=1913126|UniProtKB=O54714	E3 SUMO-protein ligase PIAS3	ISS	8682149	PubMed	PTHR10782:SF10	E3 SUMO-PROTEIN LIGASE PIAS3
P00057	Wnt signaling pathway	P01440	Cadherin	DROME|FlyBase=FBgn0000497|UniProtKB=Q24292	Protein dachsous	IDA	8120095	PubMed	PTHR24026:SF54	PROTEIN DACHSOUS
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CANLF|Ensembl=ENSCAFG00000000332|UniProtKB=F1P8E3	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MACMU|Ensembl=ENSMMUG00000010031|UniProtKB=F6Q193	TGF-beta receptor type-2	ISS	9759503	PubMed	PTHR23255:SF55	TGF-BETA RECEPTOR TYPE-2
P00012	Cadherin signaling pathway	P00477	GSK3beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	MACMU|Ensembl=ENSMMUG00000017022|UniProtKB=F7HQZ9	Uncharacterized protein	ISS	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00005	Angiogenesis	P00220	c-Jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00005	Angiogenesis	P00219	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00018	EGF receptor signaling pathway	P00558	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	BOVIN|Ensembl=ENSBTAG00000000219|UniProtKB=F1MCL3	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00010	B cell activation	P00367	NFAT	HUMAN|HGNC=7778|UniProtKB=Q14934	Nuclear factor of activated T-cells, cytoplasmic 4	IDA	9462517	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	10395542	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	CHICK|Ensembl=ENSGALG00000006885|UniProtKB=P08642	GTPase HRas	ISS	87226391	PubMed	PTHR24070:SF385	GTPASE HRAS
P00005	Angiogenesis	P00227	PLA2	MACMU|Ensembl=ENSMMUG00000003842|UniProtKB=F7HAF3	Phospholipase A2	ISS			PTHR10728:SF32	CYTOSOLIC PHOSPHOLIPASE A2 BETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	PANTR|Ensembl=ENSPTRG00000010617|UniProtKB=H2QFL8	Notch 3	ISS	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	CANLF|Ensembl=ENSCAFG00000014736|UniProtKB=F1PGV0	Clathrin heavy chain	ISS	9388255	PubMed	PTHR10292:SF6	CLATHRIN HEAVY CHAIN 2
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00012	Cadherin signaling pathway	P00475	Frizzled	RAT|RGD=631406|UniProtKB=Q8CHL0	Frizzled-5	ISS	11212302	PubMed	PTHR11309:SF126	FRIZZLED-5
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000007882|UniProtKB=G3X7Z2	Uncharacterized protein	ISS	11976940	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00020	FAS signaling pathway	P00610	MKK4	HUMAN|HGNC=6844|UniProtKB=P45985	Dual specificity mitogen-activated protein kinase kinase 4	TAS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00034	Integrin signalling pathway	P00951	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05730	Endogenous cannabinoid signaling	P05746	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000003497|UniProtKB=F7E6Z1	Uncharacterized protein	ISS	8120095	PubMed	PTHR24026:SF37	PROTOCADHERIN FAT 2
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	10802295	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00057	Wnt signaling pathway	P01465	Ggamma	PANTR|Ensembl=ENSPTRG00000000843|UniProtKB=H2QZN8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00047	PDGF signaling pathway	P01143	ERK	RAT|RGD=628675|UniProtKB=Q9Z2A6	Mitogen-activated protein kinase 15	ISS	12787066	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	XENTR|Xenbase=XB-GENE-5801166|UniProtKB=F6ZE26	Uncharacterized protein	ISS	8576107	PubMed	PTHR24070:SF382	RAS-RELATED PROTEIN RAP-1B
P00059	p53 pathway	G04694	p110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00034	Integrin signalling pathway	P00920	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00006	Apoptosis signaling pathway	P00295	Caspase 10	HUMAN|HGNC=1500|UniProtKB=Q92851	Caspase-10	IDA	11717445	PubMed	PTHR10454:SF26	CASPASE-10
P00054	Toll receptor signaling pathway	P01352	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P06211	BMP/activin signaling pathway-drosophila	P06256	Full-length  BMP orthologous ligand	DROME|FlyBase=FBgn0026199|UniProtKB=Q9V4F4	LD29161p	RCA	16098524	PubMed	PTHR11848:SF176	LD29161P
P00018	EGF receptor signaling pathway	P00557	PI3K	CAEEL|WormBase=WBGene00006932|UniProtKB=Q9TXI7	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	STRPU|EnsemblGenome=SPU_012282|UniProtKB=W4Y969	Uncharacterized protein	IDA	14684598	PubMed	PTHR11937:SF369	ACTIN-42A
P00005	Angiogenesis	P00184	Src	PANTR|Ensembl=ENSPTRG00000013474|UniProtKB=H2QKB4	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00056	VEGF signaling pathway	P01409	cPLA2	MACMU|Ensembl=ENSMMUG00000003842|UniProtKB=F7HAF3	Phospholipase A2	ISS	1709551	gi	PTHR10728:SF32	CYTOSOLIC PHOSPHOLIPASE A2 BETA
P00048	PI3 kinase pathway	P01205	NOS	RAT|RGD=3186|UniProtKB=Q62600	Nitric oxide synthase, endothelial	ISS	93055452	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05731	GABA-B receptor II signaling	P05754	Ggamma	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00004	Alzheimer disease-presenilin pathway	P00111	C99	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00010	B cell activation	P00384	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00190	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00021	FGF signaling pathway	P00634	MEKK1-5	BOVIN|Ensembl=ENSBTAG00000008151|UniProtKB=F1MH06	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	PANTR|Ensembl=ENSPTRG00000010617|UniProtKB=H2QFL8	Notch 3	ISS	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P06664	Gonadotropin-releasing hormone receptor pathway	P06830	AMPK	MOUSE|MGI=MGI=1336185|UniProtKB=Q6PAM0	5'-AMP-activated protein kinase subunit beta-2	RCA			PTHR10343:SF45	5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2
P00011	Blood coagulation	P00440	ATIII	MOUSE|MGI=MGI=88095|UniProtKB=P32261	Antithrombin-III	ISS	18252782	gi	PTHR11461:SF53	ANTITHROMBIN-III
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9441|UniProtKB=P51817	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00056	VEGF signaling pathway	P01407	Erk	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00646	RasGAP	HUMAN|HGNC=9872|UniProtKB=Q15283	Ras GTPase-activating protein 2	ISS	20475167	gi	PTHR10194:SF21	RAS GTPASE-ACTIVATING PROTEIN 2
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00034	Integrin signalling pathway	P00907	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	IDA	98269030	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ANOGA|EnsemblGenome=AGAP000651|UniProtKB=P84185	Actin-5C	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00021	FGF signaling pathway	P00638	PLCgamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BOVIN|Ensembl=ENSBTAG00000022671|UniProtKB=F1MZV4	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00644	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	IPI	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00036	Interleukin signaling pathway	P00996	STAT	RAT|RGD=3772|UniProtKB=P52631	Signal transducer and activator of transcription 3	IC	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TRYB2|Gene=Tb09.211.0620|UniProtKB=Q38E94	Actin A	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00012	Cadherin signaling pathway	P00463	betacatenin	CHICK|Ensembl=ENSGALG00000011905|UniProtKB=F1NHT7	Uncharacterized protein	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00056	VEGF signaling pathway	P01411	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00004	Alzheimer disease-presenilin pathway	P00167	CD44 transmembrane fragment	RAT|RGD=2307|UniProtKB=P26051	CD44 antigen	IDA	14871815	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P00034	Integrin signalling pathway	P00925	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00053	T cell activation	P01315	Calcineurin	CANLF|Ensembl=ENSCAFG00000010644|UniProtKB=F2Z4P5	Serine/threonine-protein phosphatase	ISS	12015605	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	HUMAN|HGNC=1392|UniProtKB=Q15878	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	14624853	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	IC	15621031	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	RAT|RGD=71012|UniProtKB=Q08464	Frizzled-2	TAS	8717036	PubMed	PTHR11309:SF34	FRIZZLED-2
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	MACMU|Ensembl=ENSMMUG00000000135|UniProtKB=F7H624	Excitatory amino acid transporter 3	ISS	94365697	PubMed	PTHR11958:SF69	EXCITATORY AMINO ACID TRANSPORTER 3
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01284	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00036	Interleukin signaling pathway	P00996	STAT	RAT|RGD=3772|UniProtKB=P52631	Signal transducer and activator of transcription 3	IC	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	ANOGA|EnsemblGenome=AGAP010064|UniProtKB=Q7PJW8	AGAP010064-PA	ISS	11313498	PubMed	PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	RAT|RGD=2735|UniProtKB=Q63273	Glutamate receptor ionotropic, kainate 5	ISS	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00004	Alzheimer disease-presenilin pathway	P00137	Tip60	MOUSE|MGI=MGI=2182799|UniProtKB=Q5SVQ0	Histone acetyltransferase KAT7	ISS			PTHR10615:SF102	HISTONE ACETYLTRANSFERASE KAT7
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MONDO|Ensembl=ENSMODG00000018065|UniProtKB=F7G485	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02738	De novo purine biosynthesis	P02892	5-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase	AQUAE|EnsemblGenome=aq_597|UniProtKB=O66856	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00006	Apoptosis signaling pathway	P00310	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	DROME|FlyBase=FBgn0040206|UniProtKB=Q9V393	Kurtz arrestin	ISS	11742073	PubMed	PTHR11792:SF17	KURTZ ARRESTIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00059	p53 pathway	P04609	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02747	Histidine biosynthesis	P02990	Histidinol-phosphatase	BACTN|EnsemblGenome=BT_1478|UniProtKB=Q8A7P6	Putative histidinol-phosphatase	ISS			PTHR21039:SF0	HISTIDINOL-PHOSPHATASE
P00021	FGF signaling pathway	P00644	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IGI	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IGI	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	MACMU|Ensembl=ENSMMUG00000009054|UniProtKB=F7F735	Uncharacterized protein	ISS	20112749	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00005	Angiogenesis	P00200	Dsh	DANRE|ZFIN=ZDB-GENE-010319-1|UniProtKB=B8JMI2	Uncharacterized protein	ISS	10409711	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P05913	Enkephalin release	P05974	G-Protein (i)	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00053	T cell activation	P01312	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P05730	Endogenous cannabinoid signaling	P05748	mGluR	PANTR|Ensembl=ENSPTRG00000018684|UniProtKB=C7G3M7	Glutamate receptor, metabotropic 1	ISS	14614461	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	DICDI|dictyBase=DDB_G0282813|UniProtKB=O96623	Actin-related protein 2/3 complex subunit 2	ISS			PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P02753	Methionine biosynthesis	P03024	Homocysteine transmethylase	CANLF|Ensembl=ENSCAFG00000010464|UniProtKB=E2R716	Uncharacterized protein	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00018	EGF receptor signaling pathway	P00564	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	DROME|FlyBase=FBgn0004509|UniProtKB=P26016	Furin-like protease 1, isoforms 1/1-X/2	IDA	7737999	PubMed	PTHR42884:SF3	FURIN-LIKE PROTEASE 1, ISOFORMS 1/1-X/2
P00049	Parkinson disease	P01215	Syntaxin	PANTR|Ensembl=ENSPTRG00000000416|UniProtKB=H2PYG1	Syntaxin 12	ISS	10321247	PubMed	PTHR19957:SF88	SYNTAXIN-12
P00036	Interleukin signaling pathway	P00983	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00941	Integrin alpha	RAT|RGD=1593249|UniProtKB=D3ZMQ3	Protein Itga4	ISS	11035110	PubMed	PTHR23220:SF78	INTEGRIN ALPHA-4
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00036	Interleukin signaling pathway	P00990	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	SCHPO|PomBase=SPAC1486.04c|UniProtKB=Q9UTK5	Abnormal long morphology protein 1	IC			PTHR18898:SF2	NUCLEOPROTEIN TPR
P00050	Plasminogen activating cascade	P01253	Fibrin	HUMAN|HGNC=3694|UniProtKB=P02679	Fibrinogen gamma chain	IDA	223170	gi	PTHR19143:SF338	FIBRINOGEN GAMMA CHAIN
P02728	Arginine biosynthesis	P02841	argininosuccinate lyase	ANOGA|Gene=AgaP_AGAP008141|UniProtKB=Q7Q410	AGAP008141-PA (Fragment)	ISS			PTHR43814:SF1	ARGININOSUCCINATE LYASE
P00006	Apoptosis signaling pathway	P00269	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04397	p53 pathway by glucose deprivation	P04641	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01162	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	CAEBR|Gene=CBG_05938|UniProtKB=H8WGV2	Protein CBR-ITR-1, isoform a	ISS	11007872	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00012	Cadherin signaling pathway	P00470	F-actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	TAS	11707292	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00006	Apoptosis signaling pathway	P00269	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00200	Dsh	BOVIN|Ensembl=ENSBTAG00000003075|UniProtKB=E1BK34	Uncharacterized protein	ISS	10409711	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	SCHPO|PomBase=SPAC17H9.09c|UniProtKB=P08647	Ras-like protein 1	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IGI	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P06959	CCKR signaling map	P07088	RYR1/2/3	HUMAN|HGNC=10483|UniProtKB=P21817	Ryanodine receptor 1	RCA	2008014	PubMed	PTHR13715:SF15	RYANODINE RECEPTOR 1
P00048	PI3 kinase pathway	P01202	p85	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00036	Interleukin signaling pathway	P00964	p90RSK	CHICK|Ensembl=ENSGALG00000011473|UniProtKB=F1P1H2	Ribosomal protein S6 kinase	ISS	1922062	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MONDO|Ensembl=ENSMODG00000001430|UniProtKB=F7BCI5	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00012	Cadherin signaling pathway	P00474	Wnt	BOVIN|Ensembl=ENSBTAG00000009217|UniProtKB=F1MEW8	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00029	Huntington disease	P00774	Dynein complex	DANRE|ZFIN=ZDB-GENE-050320-132|UniProtKB=Q5BL99	Dnl2l protein	ISS	9454836	PubMed	PTHR11886:SF35	DYNEIN LIGHT CHAIN 2, CYTOPLASMIC
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	CANLF|Ensembl=ENSCAFG00000013283|UniProtKB=E2RIZ9	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF74	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA
P00029	Huntington disease	P00775	Rac	CHICK|Ensembl=ENSGALG00000002859|UniProtKB=F6UBD2	Uncharacterized protein	ISS	9252344	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000008826|UniProtKB=F6XUU0	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01411	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	RAT|RGD=619879|UniProtKB=G3V816	Nucleoside diphosphate kinase	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00562	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04393	Ras Pathway	P04552	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00034	Integrin signalling pathway	P00951	Jnk	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IDA	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	BOVIN|Gene=CHRNA3|UniProtKB=Q07263	Neuronal acetylcholine receptor subunit alpha-3	ISS	12098588	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00057	Wnt signaling pathway	P01437	TCF	DANRE|ZFIN=ZDB-GENE-980605-30|UniProtKB=Q9YHE8	Transcription factor 7-like 1-A	IDA	11266476	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00059	p53 pathway	P04626	GADD45	HUMAN|HGNC=4097|UniProtKB=O95257	Growth arrest and DNA damage-inducible protein GADD45 gamma	IGI	10097101	PubMed	PTHR10411:SF4	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 GAMMA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	BOVIN|Ensembl=ENSBTAG00000006495|UniProtKB=P11017	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00056	VEGF signaling pathway	P01407	Erk	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04546	GSK3	DICDI|dictyBase=DDB_G0272110|UniProtKB=P51136	Glycogen synthase kinase-3	IDA	12615961	PubMed	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	SCHPO|PomBase=SPAC15E1.04|UniProtKB=Q9UTI7	Probable thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00034	Integrin signalling pathway	P00924	Raf	MOUSE|MGI=MGI=88190|UniProtKB=P28028	Serine/threonine-protein kinase B-raf	IPI	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MONDO|Ensembl=ENSMODG00000023683|UniProtKB=F6T0L6	Uncharacterized protein (Fragment)	ISS			PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P04396	Vitamin D metabolism and pathway	P04604	FdxR	MACMU|Ensembl=ENSMMUG00000015648|UniProtKB=F6RKZ7	NADPH:adrenodoxin oxidoreductase, mitochondrial	ISS	2845396	PubMed	PTHR11938:SF91	NADPH:ADRENODOXIN OXIDOREDUCTASE, MITOCHONDRIAL
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MONDO|Ensembl=ENSMODG00000004648|UniProtKB=F6UN99	Metalloendopeptidase (Fragment)	ISS			PTHR43978:SF1	TOLLOID-LIKE PROTEIN 2
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00046	Oxidative stress response	P01129	JNK1/2	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	MOUSE|MGI=MGI=1278315|UniProtKB=Q91VN0	Low-density lipoprotein receptor-related protein 5	ISS	11029006	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00029	Huntington disease	P00807	Actin	ORYSJ|Gene=Os01g0866100|UniProtKB=P0C540	Actin-7	IDA	14684598	PubMed	PTHR11937:SF205	SUBFAMILY NOT NAMED
P02741	Flavin biosynthesis	P02936	FAD synthetase	MOUSE|MGI=MGI=1914688|UniProtKB=Q8CFV9	Riboflavin kinase	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=109356|UniProtKB=O09044	Synaptosomal-associated protein 23	IC	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00057	Wnt signaling pathway	P01465	Ggamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00006	Apoptosis signaling pathway	P00303	c-Jun	XENTR|Xenbase=XB-GENE-482228|UniProtKB=F6RYL1	Uncharacterized protein	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00056	VEGF signaling pathway	P01417	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00059	p53 pathway	G04704	KAI	MACMU|Ensembl=ENSMMUG00000019268|UniProtKB=F6SIU0	Tetraspanin	ISS	12474542	PubMed	PTHR19282:SF44	CD82 ANTIGEN
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000005917|UniProtKB=F6QM53	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00048	PI3 kinase pathway	P01202	p85	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00001	Adrenaline and noradrenaline biosynthesis	P00066	DOPA decarb.	DROME|FlyBase=FBgn0000422|UniProtKB=P05031	Aromatic-L-amino-acid decarboxylase	ISS	7567987	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00047	PDGF signaling pathway	P01167	Ets	MOUSE|MGI=MGI=1101781|UniProtKB=Q3UPW2	ETS-related transcription factor Elf-3	ISS	15298723	PubMed	PTHR11849:SF13	ETS-RELATED TRANSCRIPTION FACTOR ELF-3
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04393	Ras Pathway	P04552	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P02783	Tryptophan biosynthesis	P03209	Anthranilate phosphoribosyl transferase	STRCO|Gene=CAB38584|UniProtKB=Q9Z4W8	Probable anthranilate synthase component II	ISS			PTHR43418:SF4	MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	RAT|RGD=3381|UniProtKB=P62716	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	MONDO|Ensembl=ENSMODG00000017515|UniProtKB=F7F0J5	Uncharacterized protein	ISS	600075	OMIM	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00021	FGF signaling pathway	P00641	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00053	T cell activation	P01333	cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00021	FGF signaling pathway	P00638	PLCgamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00005	Angiogenesis	P00223	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00194	Paxillin	HUMAN|HGNC=9718|UniProtKB=P49023	Paxillin	ISS	7579684	PubMed	PTHR24216:SF11	PAXILLIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CAEEL|WormBase=WBGene00002037|UniProtKB=Q20456	Heavy chain, Unconventional Myosin	IC			PTHR13140:SF709	PERICENTRIN-LIKE PROTEIN, ISOFORM F
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00012	Cadherin signaling pathway	P00470	F-actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	IC	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04398	p53 pathway feedback loops 2	G04714	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00034	Integrin signalling pathway	P00948	Rho	BOVIN|Ensembl=ENSBTAG00000014299|UniProtKB=Q1RMJ6	Rho-related GTP-binding protein RhoC	ISS	12090470	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00047	PDGF signaling pathway	P01171	PLCgamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	BOVIN|Ensembl=ENSBTAG00000004242|UniProtKB=Q1JP79	Actin-related protein 2/3 complex subunit 1A	ISS	12473693	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00005	Angiogenesis	P00211	GSK3beta	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00020	FAS signaling pathway	P00611	Gelsolin	RAT|RGD=735034|UniProtKB=E9PU64	Protein Scin	ISS	9323209	PubMed	PTHR11977:SF78	ADSEVERIN
P00009	Axon guidance mediated by netrin	P00363	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00962	ELK	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	IDA	14670631	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P05731	GABA-B receptor II signaling	P05758	K channel	PANTR|Ensembl=ENSPTRG00000012547|UniProtKB=H2QIU3	Uncharacterized protein	ISS	2433589	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000018853|UniProtKB=F6XSK8	Uncharacterized protein	ISS	12562507	PubMed	PTHR24229:SF42	SOMATOSTATIN RECEPTOR TYPE 3
P00018	EGF receptor signaling pathway	P00554	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	95096035	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P02783	Tryptophan biosynthesis	P03208	Tryptophan synthase B	BACSU|EnsemblGenome=BSU22640|UniProtKB=P07600	Tryptophan synthase beta chain	ISS			PTHR42882:SF1	TRYPTOPHAN SYNTHASE
P02762	Pentose phosphate pathway	P03070	Gluconate Dehydrogenase	BOVIN|Ensembl=ENSBTAG00000013527|UniProtKB=Q3ZCI4	6-phosphogluconate dehydrogenase, decarboxylating	ISS	8978909	PubMed	PTHR11811:SF25	6-PHOSPHOGLUCONATE DEHYDROGENASE, DECARBOXYLATING
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000001384|UniProtKB=F7GL73	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00010	B cell activation	P00384	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00048	PI3 kinase pathway	P01192	p110	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01230	Src kinase	CANLF|Ensembl=ENSCAFG00000003995|UniProtKB=E2RC09	Tyrosine-protein kinase	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00029	Huntington disease	P00780	Microtubule	PRIPA|Gene=PPA21758|UniProtKB=H3FHL1	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF89	TUBULIN BETA-4 CHAIN
P00009	Axon guidance mediated by netrin	P00363	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00001	Adrenaline and noradrenaline biosynthesis	P00068	amine translocator	PANTR|Ensembl=ENSPTRG00000016695|UniProtKB=H2R3L2	Transporter	ISS	12719981	PubMed	PTHR11616:SF109	SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER B 0 AT3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	HUMAN|HGNC=4616|UniProtKB=P49840	Glycogen synthase kinase-3 alpha	TAS	12086949	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00005	Angiogenesis	P00211	GSK3beta	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04542	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00631	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	15210125	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00269	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01315	Calcineurin	MOUSE|MGI=MGI=107162|UniProtKB=P48455	Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform	IGI	7532676	PubMed	PTHR11668:SF186	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT GAMMA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	CHICK|Ensembl=ENSGALG00000015835|UniProtKB=F1NZT2	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00019	Endothelin signaling pathway	P00566	ERK	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00047	PDGF signaling pathway	P01160	IP3 receptor	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00057	Wnt signaling pathway	P01446	Calcineurin	MONDO|Ensembl=ENSMODG00000020679|UniProtKB=F7DKU1	Serine/threonine-protein phosphatase	ISS	12015605	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	CAEEL|WormBase=WBGene00000201|UniProtKB=Q9U1R7	ARp2/3 compleX component	ISS	12932731	PubMed	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P00018	EGF receptor signaling pathway	P00541	Spry	MACMU|Ensembl=ENSMMUG00000014175|UniProtKB=F7ALK4	Uncharacterized protein	ISS	22024232	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05918	p38 MAPK pathway	P06023	MEF	PANTR|Ensembl=ENSPTRG00000007496|UniProtKB=H2QA54	Uncharacterized protein	ISS	11274345	PubMed	PTHR11945:SF145	MYOCYTE-SPECIFIC ENHANCER FACTOR 2A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CHICK|Ensembl=ENSGALG00000019382|UniProtKB=E1BWK1	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00048	PI3 kinase pathway	P01179	PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00623	FGF	HUMAN|HGNC=3682|UniProtKB=P08620	Fibroblast growth factor 4	ISS	96032369	PubMed	PTHR11486:SF31	FIBROBLAST GROWTH FACTOR 4
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	ARATH|TAIR=AT4G37930|UniProtKB=Q9SZJ5	Serine hydroxymethyltransferase 1, mitochondrial	ISS			PTHR11680:SF21	SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IDA	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00018	EGF receptor signaling pathway	P00552	Ras	CHICK|Ensembl=ENSGALG00000014033|UniProtKB=E1BTS2	Uncharacterized protein	ISS	3023884	PubMed	PTHR24070:SF186	GTPASE KRAS
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00052	TGF-beta signaling pathway	P01275	P38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00006	Apoptosis signaling pathway	P00318	PKCs	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00558	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000016755|UniProtKB=H2QQP6	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF96	CADHERIN-12
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=3025|UniProtKB=P21917	D(4) dopamine receptor	IDA	11248120	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ASHGO|EnsemblGenome=AGOS_ABR222W|UniProtKB=Q75D00	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00021	FGF signaling pathway	P00634	MEKK1-5	RAT|RGD=1311192|UniProtKB=A0A0G2K3R1	Protein Map3k4	ISS	602425	OMIM	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00477	GSK3beta	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	IDA	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	ARATH|TAIR=AT2G21790|UniProtKB=Q9SJ20	Ribonucleoside-diphosphate reductase large subunit	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00021	FGF signaling pathway	P00628	JNK1-3	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00013	Cell cycle	P00480	Proteasome	DROME|FlyBase=FBgn0028691|UniProtKB=Q7KMP8	26S proteasome regulatory complex subunit p39A	ISS	20351422	PubMed	PTHR10539:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13
P02783	Tryptophan biosynthesis	P03206	Anthranilate synthase	YEAST|SGD=S000001694|UniProtKB=P00937	Multifunctional tryptophan biosynthesis protein	RCA			PTHR43418:SF4	MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN
P05913	Enkephalin release	P05974	G-Protein (i)	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00402	Jnk	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	176892	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P05731	GABA-B receptor II signaling	P05752	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CHICK|Ensembl=ENSGALG00000006576|UniProtKB=E1BUE5	Uncharacterized protein	ISS	20012997	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	HUMAN|HGNC=4383|UniProtKB=P30679	Guanine nucleotide-binding protein subunit alpha-15	IDA	11359849	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P00029	Huntington disease	P00780	Microtubule	ORYSJ|EnsemblGenome=OS03G0780600|UniProtKB=P37832	Tubulin beta-7 chain	IDA	9454836	PubMed	PTHR11588:SF146	SUBFAMILY NOT NAMED
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	XENTR|Ensembl=ENSXETG00000030140|UniProtKB=F7EP58	Uncharacterized protein (Fragment)	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	HUMAN|HGNC=10483|UniProtKB=P21817	Ryanodine receptor 1	ISS	15858232	PubMed	PTHR13715:SF15	RYANODINE RECEPTOR 1
P02736	Coenzyme A biosynthesis	P02884	Dephospho-CoA kinase	DROME|FlyBase=FBgn0037469|UniProtKB=Q9VI57	Dephospho-CoA kinase	ISS			PTHR10695:SF35	DEPHOSPHO-COA KINASE DOMAIN-CONTAINING PROTEIN
P00029	Huntington disease	P00807	Actin	BOVIN|Gene=ACTG2|UniProtKB=Q5E9B5	Actin, gamma-enteric smooth muscle	ISS	3487386	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00056	VEGF signaling pathway	P01411	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00049	Parkinson disease	P01238	14-3-3	RAT|RGD=62002|UniProtKB=P61983	14-3-3 protein gamma	ISS	99360936	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P02741	Flavin biosynthesis	P02933	Pyrimidine deaminase	CHLTR|EnsemblGenome=CT_730|UniProtKB=O84735	Riboflavin biosynthesis protein RibD	ISS			PTHR44288:SF1	RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBD
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	MACMU|Ensembl=ENSMMUG00000001661|UniProtKB=F7GR69	Uncharacterized protein	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00034	Integrin signalling pathway	P00916	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CAEEL|WormBase=WBGene00001612|UniProtKB=P34299	Glutamate receptor 1	IC	10331083	PubMed	PTHR18966:SF297	GLUTAMATE RECEPTOR 1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CAEEL|WormBase=WBGene00004037|UniProtKB=Q9XWB7	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF9	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	PANTR|Ensembl=ENSPTRG00000009552|UniProtKB=H2QDP8	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF170	REGULATOR OF G-PROTEIN SIGNALING 9
P00052	TGF-beta signaling pathway	P01292	RSmads	BOVIN|Ensembl=ENSBTAG00000002835|UniProtKB=Q1JQA2	Mothers against decapentaplegic homolog 1	ISS	9395284	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P00012	Cadherin signaling pathway	P00475	Frizzled	PANTR|Ensembl=ENSPTRG00000028542|UniProtKB=H2R591	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF79	FRIZZLED-9
P04375	5HT3 type receptor mediated signaling pathway	P04422	5HT3 Rec	MOUSE|MGI=MGI=1861899|UniProtKB=Q9JHJ5	5-hydroxytryptamine receptor 3B	IC	7509203	PubMed	PTHR18945:SF53	5-HYDROXYTRYPTAMINE RECEPTOR 3B
P00057	Wnt signaling pathway	P01444	Wnt	ORNAN|Ensembl=ENSOANG00000011077|UniProtKB=F7FK62	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IC	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00006	Apoptosis signaling pathway	P00298	Caspase 9	HUMAN|HGNC=1511|UniProtKB=P55211	Caspase-9	IDA	8663294	PubMed	PTHR10454:SF157	CASPASE-9
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00892	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	4504111	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00021	FGF signaling pathway	P00644	p38	CAEBR|Gene=CBG01555|UniProtKB=A8WRD7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CAEBR|Gene=CBG01555|UniProtKB=A8WRD7	Mitogen-activated protein kinase	ISS			PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	PANTR|Ensembl=ENSPTRG00000022053|UniProtKB=H2R4N5	Uncharacterized protein	ISS			PTHR12595:SF3	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 9B
P00056	VEGF signaling pathway	P01425	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	10644715	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	14765990	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IDA	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04542	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	XENTR|Xenbase=XB-GENE-962073|UniProtKB=Q08D63	Syntaxin 2	ISS			PTHR19957:SF36	SYNTAXIN-2
P04393	Ras Pathway	P04543	MEKK1/4	BOVIN|Ensembl=ENSBTAG00000013790|UniProtKB=E1B847	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00029	Huntington disease	P00797	p53	HUMAN|HGNC=15979|UniProtKB=Q9H3D4	Tumor protein 63	TAS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P02744	Fructose galactose metabolism	P02966	Hexokinase	MACMU|Ensembl=ENSMMUG00000003849|UniProtKB=F7HAC6	Uncharacterized protein	RCA			PTHR19443:SF28	HEXOKINASE HKDC1-RELATED
P00010	B cell activation	P00402	Jnk	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9060|UniProtKB=P51178	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	15611108	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00021	FGF signaling pathway	P00624	14-3-3	XENTR|Xenbase=XB-GENE-970616|UniProtKB=Q6P4Z5	14-3-3 protein zeta	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00060	Ubiquitin proteasome pathway	P01491	E2	DROME|FlyBase=FBgn0015321|UniProtKB=P52486	Ubiquitin-conjugating enzyme E2-22 kDa	ISS			PTHR44020:SF2	UBIQUITIN-CONJUGATING ENZYME E2 K
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00018	EGF receptor signaling pathway	P00547	PP2A	RAT|RGD=1308022|UniProtKB=D3ZDI7	Protein Ppp2r5a	ISS	12110603	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00302	ATF	HUMAN|HGNC=784|UniProtKB=P15336	Cyclic AMP-dependent transcription factor ATF-2	ISS	11390664	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BOVIN|Ensembl=ENSBTAG00000014291|UniProtKB=A6H6X8	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P04393	Ras Pathway	P04559	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00539	14-3-3	HUMAN|HGNC=12854|UniProtKB=P27348	14-3-3 protein theta	IGI	5803227	gi	PTHR18860:SF3	14-3-3 PROTEIN THETA
P05918	p38 MAPK pathway	P06033	TAB2	MACMU|Ensembl=ENSMMUG00000014995|UniProtKB=F6VE69	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2	ISS			PTHR10351:SF27	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00059	p53 pathway	P04635	Sumo-1 ligase	CHICK|Ensembl=ENSGALG00000008435|UniProtKB=Q8QGH2	Small ubiquitin-related modifier 1	ISS			PTHR10562:SF52	SMALL UBIQUITIN-RELATED MODIFIER 1
P00054	Toll receptor signaling pathway	P01376	Uev1A	CAEBR|Gene=CBG19710|UniProtKB=A8XWI0	Protein CBR-UEV-1	ISS			PTHR43915:SF5	LD28904P
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	BOVIN|Gene=CSNK2A2|UniProtKB=P20427	Casein kinase II subunit alpha'	IDA	10806215	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P02772	Pyruvate metabolism	P03141	Citrate Synthetase	ECOLI|EcoGene=EG10402|UniProtKB=P0ABH7	Citrate synthase	ISS	11206551	PubMed	PTHR42871:SF1	CITRATE SYNTHASE
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00005	Angiogenesis	P00182	p38MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00011	Blood coagulation	P00443	Fibrin polymer cross-linked	HUMAN|HGNC=3661|UniProtKB=P02671	Fibrinogen alpha chain	ISS	6575700	PubMed	PTHR19143:SF232	FIBRINOGEN ALPHA CHAIN
P00029	Huntington disease	P00805	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12539654	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01159	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	MACMU|Ensembl=ENSMMUG00000000042|UniProtKB=F7HPH2	Serine/threonine-protein kinase receptor	ISS	9395284	PubMed	PTHR23255:SF64	ACTIVIN RECEPTOR TYPE-2A
P00005	Angiogenesis	P00236	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01322	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	IGI	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04393	Ras Pathway	P04570	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01313	CD28	MACMU|Ensembl=ENSMMUG00000006017|UniProtKB=F7CGP5	Uncharacterized protein	ISS	7534617	PubMed	PTHR11494:SF7	T-CELL-SPECIFIC SURFACE GLYCOPROTEIN CD28
P00054	Toll receptor signaling pathway	P01360	IKKbeta	HUMAN|HGNC=5960|UniProtKB=O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00035	Interferon-gamma signaling pathway	P00952	Jak2	BOVIN|Ensembl=ENSBTAG00000012047|UniProtKB=E1BCP6	Tyrosine-protein kinase	ISS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=8156|UniProtKB=P35372	Mu-type opioid receptor	IDA	11259487	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04558	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00015	Circadian clock system	G01497	cry	RAT|RGD=620935|UniProtKB=Q923I8	Cryptochrome-2	IDA	11804325	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	IDA	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00018	EGF receptor signaling pathway	P00564	Rac	MACMU|Ensembl=ENSMMUG00000021075|UniProtKB=F7GY91	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	RAT|RGD=1309504|UniProtKB=D3ZRN3	Protein Actbl2	ISS	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_206575|UniProtKB=E9FUX0	Guanine nucleotide binding protein, beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	ISS	10553940	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00029	Huntington disease	P00811	Arp2/3 complex	MONDO|Ensembl=ENSMODG00000007194|UniProtKB=F6X9N6	Actin-related protein 2/3 complex subunit 5	ISS	10322212	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00029	Huntington disease	P00796	Kainate receptor	MOUSE|MGI=MGI=95814|UniProtKB=Q60934	Glutamate receptor ionotropic, kainate 1	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00047	PDGF signaling pathway	P01163	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04393	Ras Pathway	P04558	p38	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	IDA	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00021	FGF signaling pathway	P00639	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	7798194	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=11438|UniProtKB=Q13277	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00053	T cell activation	P01324	rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01153	GSK3	ARATH|TAIR=AT1G57870|UniProtKB=Q9FVS6	Shaggy-related protein kinase delta	ISS	12615961	PubMed	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00021	FGF signaling pathway	P00633	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	PANTR|Ensembl=ENSPTRG00000040283|UniProtKB=H2RII6	Suppressor of cytokine signaling 5	ISS	22247722	PubMed	PTHR44282:SF3	SUPPRESSOR OF CYTOKINE SIGNALING 5
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00047	PDGF signaling pathway	P01161	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00047	PDGF signaling pathway	P01161	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00006	Apoptosis signaling pathway	P00260	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	TAKRU|Ensembl=ENSTRUG00000015125|UniProtKB=H2UNW4	Uncharacterized protein	ISS	9783586	PubMed	PTHR10814:SF24	TRANSDUCIN-LIKE ENHANCER PROTEIN 3
P00057	Wnt signaling pathway	P01451	Galpha	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IDA	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00990	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00912	Arp2/3	RAT|RGD=2155|UniProtKB=O88656	Actin-related protein 2/3 complex subunit 1B	IPI	12473693	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00018	EGF receptor signaling pathway	P00565	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	IGI	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008422|UniProtKB=F6VUT7	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00010	B cell activation	P00401	jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00059	p53 pathway	G04694	p110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	ANOGA|Gene=AgaP_AGAP009315|UniProtKB=A0NC47	AGAP009315-PA (Fragment)	ISS			PTHR11920:SF291	ADENYLATE CYCLASE TYPE 3
P00047	PDGF signaling pathway	P01168	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	MOUSE|MGI=MGI=102891|UniProtKB=P51829	Adenylate cyclase type 7	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00045	Notch signaling pathway	P01120	NIcs	CANLF|Ensembl=ENSCAFG00000010476|UniProtKB=F1PS94	Uncharacterized protein	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	IDA	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P04393	Ras Pathway	P04557	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IDA	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00018	EGF receptor signaling pathway	P00564	Rac	CHICK|Ensembl=ENSGALG00000002859|UniProtKB=F6UBD2	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	ARATH|TAIR=AT4G32520|UniProtKB=Q94JQ3	Serine hydroxymethyltransferase 3, chloroplastic	ISS			PTHR11680:SF20	SERINE HYDROXYMETHYLTRANSFERASE 3, CHLOROPLASTIC
P00059	p53 pathway	G04694	p110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	TAS	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00034	Integrin signalling pathway	P00907	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	IDA	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00010	B cell activation	P00383	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	ANOGA|Gene=AgaP_AGAP010198|UniProtKB=Q5TNU6	Ribonucleoside-diphosphate reductase (Fragment)	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01437	TCF	HUMAN|HGNC=11641|UniProtKB=Q9NQB0	Transcription factor 7-like 2	IDA	12356903	PubMed	PTHR10373:SF32	TRANSCRIPTION FACTOR 7-LIKE 2
P00053	T cell activation	P01331	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P02766	Phenylethylamine degradation	P03103	Phenylethylamine oxidase	SULSO|EnsemblGenome=SSO1692|UniProtKB=Q97XM1	Amine oxidase	ISS			PTHR10638:SF41	AMINE OXIDASE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CAEBR|Gene=CBG17587|UniProtKB=A8XRA5	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00018	EGF receptor signaling pathway	P00564	Rac	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS	15470041	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	DROME|FlyBase=FBgn0004623|UniProtKB=P29829	Guanine nucleotide-binding protein subunit beta-2	ISS			PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00057	Wnt signaling pathway	P01435	SWI/SNF	MONDO|Ensembl=ENSMODG00000000391|UniProtKB=F6R7X3	Uncharacterized protein	ISS	11532957	PubMed	PTHR10799:SF887	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5
P00034	Integrin signalling pathway	P00948	Rho	HUMAN|HGNC=669|UniProtKB=P08134	Rho-related GTP-binding protein RhoC	ISS	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04397	p53 pathway by glucose deprivation	P04645	TSC1	PANTR|Ensembl=ENSPTRG00000021504|UniProtKB=H2QY35	Tuberous sclerosis 1	ISS	12820960	PubMed	PTHR15154:SF2	HAMARTIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00878	INFgamma	MOUSE|MGI=MGI=107656|UniProtKB=P01580	Interferon gamma	TAS	10553079	PubMed	PTHR11419:SF0	INTERFERON GAMMA
P00034	Integrin signalling pathway	P00920	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IPI	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Ensembl=ENSGALG00000013781|UniProtKB=F1P1D5	Uncharacterized protein	IEP	89264452	PubMed	PTHR13140:SF344	MYOSIN-7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	HUMAN|HGNC=7776|UniProtKB=Q13469	Nuclear factor of activated T-cells, cytoplasmic 2	ISS	9462517	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P04395	Vasopressin synthesis	P04593	Glycopeptide	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	IC	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00011	Blood coagulation	P00406	Fibrinogen	BOVIN|Gene=FGB|UniProtKB=P02676	Fibrinogen beta chain	ISS			PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00021	FGF signaling pathway	P00644	p38	DROME|FlyBase=FBgn0024846|UniProtKB=O61443	Mitogen-activated protein kinase 14B	ISS	11707292	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00011	Blood coagulation	P00456	HCII	MOUSE|MGI=MGI=96051|UniProtKB=P49182	Heparin cofactor 2	ISS	13242285	gi	PTHR11461:SF30	HEPARIN COFACTOR 2
P00025	Hedgehog signaling pathway	P00691	CBP	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00036	Interleukin signaling pathway	P00990	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00590	IP3 R	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04393	Ras Pathway	P04556	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01192	p110	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05913	Enkephalin release	P05972	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01438	PP2A	CHICK|Ensembl=ENSGALG00000010273|UniProtKB=P48463	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	IDA	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04541	p90RSK	BOVIN|Ensembl=ENSBTAG00000021741|UniProtKB=F1MNR5	Ribosomal protein S6 kinase	ISS	1922062	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	CAEBR|Gene=CBG13820|UniProtKB=A8XIS2	Glutamine synthetase	ISS			PTHR20852:SF64	GLUTAMINE SYNTHETASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=7605|UniProtKB=Q9UM54	Unconventional myosin-VI	IC			PTHR13140:SF706	UNCONVENTIONAL MYOSIN-VI
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IGI	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00244	MAPKAPK2/3	MACMU|Ensembl=ENSMMUG00000023567|UniProtKB=F7HHY8	Uncharacterized protein	ISS	8262198	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	MACMU|Ensembl=ENSMMUG00000019999|UniProtKB=F7FNE2	Uncharacterized protein	ISS	92370677	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00053	T cell activation	P01307	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	ISS	1482697	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00021	FGF signaling pathway	P00629	PP2A	CANLF|Ensembl=ENSCAFG00000008850|UniProtKB=E2R0J6	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B	ISS	11956189	PubMed	PTHR11871:SF2	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B ALPHA ISOFORM
P00021	FGF signaling pathway	P00640	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	10799299	PubMed	PTHR10048:SF14	PI-3 KINASE
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	11313908	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00056	VEGF signaling pathway	P01425	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00589	Akt	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	IGI	22084520	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00052	TGF-beta signaling pathway	P01286	TGFbeta	HUMAN|HGNC=4223|UniProtKB=O14793	Growth/differentiation factor 8	TAS	9759503	PubMed	PTHR11848:SF150	GROWTH/DIFFERENTIATION FACTOR 8
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ORNAN|Ensembl=ENSOANG00000007716|UniProtKB=F6UDX9	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00021	FGF signaling pathway	P00632	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	PANTR|Ensembl=ENSPTRG00000011042|UniProtKB=H2QGF5	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00011	Blood coagulation	P00438	Bradykinin	BOVIN|Gene=KNG1|UniProtKB=P01044	Kininogen-1	ISS	125505	gi	PTHR13814:SF12	KININOGEN-1
P05730	Endogenous cannabinoid signaling	P05748	mGluR	CANLF|Ensembl=ENSCAFG00000004381|UniProtKB=J9JH96	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	RAT|RGD=1309329|UniProtKB=F1MAD0	Protein Lrp5	ISS	11907044	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	PANTR|Ensembl=ENSPTRG00000023062|UniProtKB=H2R2U1	Catenin (Cadherin-associated protein), beta 1, 88kDa	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P04395	Vasopressin synthesis	P04594	Neurophysin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00029	Huntington disease	P00807	Actin	SCHMA|EnsemblGenome=Smp_046600|UniProtKB=G4VLW2	Putative actin-1	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00034	Integrin signalling pathway	P00944	Actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000002775|UniProtKB=H2RB55	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IGI	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00034	Integrin signalling pathway	P00938	Cdc42	IXOSC|EnsemblGenome=ISCW003614|UniProtKB=B7PHY7	Cdc42 protein, putative	ISS	4757952	gi	PTHR24072:SF192	CDC42 HOMOLOG
P00029	Huntington disease	P00797	p53	CHICK|Ensembl=ENSGALG00000016736|UniProtKB=E1BW56	Uncharacterized protein	ISS			PTHR12195:SF2	CYTOPLASMIC FMR1-INTERACTING PROTEIN 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05935	AngII	RAT|RGD=2069|UniProtKB=P01015	Angiotensinogen	RCA			PTHR11461:SF13	ANGIOTENSINOGEN
P00010	B cell activation	P00371	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00018	EGF receptor signaling pathway	P00560	Raf-1	DROME|FlyBase=FBgn0003079|UniProtKB=P11346	Raf homolog serine/threonine-protein kinase phl	ISS			PTHR44000:SF2	RAF HOMOLOG SERINE/THREONINE-PROTEIN KINASE PHL
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	TAS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-977853|UniProtKB=F7EBE7	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01451	Galpha	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00059	p53 pathway	P01486	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	LEIMA|EnsemblGenome=LmjF.35.3960|UniProtKB=E9AFM1	Protein kinase A catalytic subunit isoform 2	ISS	14744463	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00259	TNF	MOUSE|MGI=MGI=104797|UniProtKB=P09225	Lymphotoxin-alpha	ISS			PTHR11471:SF31	LYMPHOTOXIN-ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONBE|Gene=37852|UniProtKB=A9V489	Predicted protein	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9060|UniProtKB=P51178	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	7822322	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P02742	Tetrahydrofolate biosynthesis	P02951	GTP cyclohydrolase	DICDI|dictyBase=DDB_G0288481|UniProtKB=Q94465	GTP cyclohydrolase 1	ISS			PTHR11109:SF0	GTP CYCLOHYDROLASE 1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	HUMAN|HGNC=7852|UniProtKB=O00746	Nucleoside diphosphate kinase, mitochondrial	ISS			PTHR11349:SF49	NUCLEOSIDE DIPHOSPHATE KINASE, MITOCHONDRIAL
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	RAT|RGD=1359278|UniProtKB=Q5UEM7	Cyclic AMP-responsive element-binding protein 3-like protein 4	RCA			PTHR22952:SF105	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 4
P00059	p53 pathway	P04633	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00036	Interleukin signaling pathway	P00983	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	RAT|RGD=621375|UniProtKB=Q9QY78	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00024	Glycolysis	P00675	Pyruvate kinase	MACMU|Ensembl=ENSMMUG00000023143|UniProtKB=F7FI39	Pyruvate kinase	RCA			PTHR11817:SF31	PYRUVATE KINASE PKLR
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00057	Wnt signaling pathway	P01432	Beta-Catenin	RAT|RGD=70487|UniProtKB=Q9WU82	Catenin beta-1	IDA	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	IDA	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01439	C-terminal Binding Protein	MACMU|Ensembl=ENSMMUG00000008323|UniProtKB=F7HTZ1	C-terminal-binding protein 1 isoform 1	ISS	10375506	PubMed	PTHR10996:SF128	C-TERMINAL-BINDING PROTEIN 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	BOVIN|Gene=GRK7|UniProtKB=Q8WMV0	Rhodopsin kinase	IDA	8288567	PubMed	PTHR24355:SF12	RHODOPSIN KINASE
P00029	Huntington disease	P00807	Actin	HUMAN|HGNC=144|UniProtKB=P63261	Actin, cytoplasmic 2	IDA	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P05916	Opioid prodynorphin pathway	P06000	vasopressin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	RCA	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	YARLI|EnsemblGenome=YALI0_D08272g|UniProtKB=Q9UVF3	Actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00037	Ionotropic glutamate receptor pathway	P01026	KA	HUMAN|HGNC=4582|UniProtKB=Q16099	Glutamate receptor ionotropic, kainate 4	ISS	12871085	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00034	Integrin signalling pathway	P00951	Jnk	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	IDA	11707292	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	HUMAN|HGNC=7571|UniProtKB=Q9UKX3	Myosin-13	IEP	89264452	PubMed	PTHR13140:SF504	MYOSIN-13
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS			PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05731	GABA-B receptor II signaling	P05754	Ggamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P05913	Enkephalin release	P05974	G-Protein (i)	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DANRE|ZFIN=ZDB-GENE-040625-11|UniProtKB=A5PMJ7	Uncharacterized protein	ISS	14570579	PubMed	PTHR19957:SF88	SYNTAXIN-12
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00048	PI3 kinase pathway	P01177	P110ACT	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00010	B cell activation	P00379	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00054	Toll receptor signaling pathway	P01364	TPL2	CANLF|Ensembl=ENSCAFG00000003980|UniProtKB=E2RCV5	Uncharacterized protein	ISS	92019818	PubMed	PTHR24361:SF94	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 8
P00054	Toll receptor signaling pathway	P01346	TLR	ANOGA|EnsemblGenome=AGAP012387|UniProtKB=Q7Q0C5	AGAP012387-PA	ISS			PTHR44740:SF2	TOLL-LIKE RECEPTOR 6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00629	PP2A	MOUSE|MGI=MGI=1321161|UniProtKB=P62715	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT3G18040|UniProtKB=Q9LV37	Mitogen-activated protein kinase 9	ISS	176948	OMIM	PTHR24055:SF246	MITOGEN-ACTIVATED PROTEIN KINASE 15-RELATED
P00029	Huntington disease	P00781	Dynactin	HUMAN|HGNC=2711|UniProtKB=Q14203	Dynactin subunit 1	IPI	9454836	PubMed	PTHR18916:SF40	DYNACTIN SUBUNIT 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	TAS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00049	Parkinson disease	P01232	CASK	CHICK|Ensembl=ENSGALG00000016226|UniProtKB=E1BWL4	Uncharacterized protein	ISS	11430913	PubMed	PTHR23122:SF40	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00029	Huntington disease	P00774	Dynein complex	ANOGA|EnsemblGenome=AGAP003226|UniProtKB=Q7QBD1	AGAP003226-PA (Fragment)	IPI	9454836	PubMed	PTHR10676:SF339	DYNEIN HEAVY CHAIN 6, AXONEMAL
P00054	Toll receptor signaling pathway	P01367	MKK3	CANLF|Ensembl=ENSCAFG00000018530|UniProtKB=F1PXD3	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00005	Angiogenesis	P00189	Fzd	RAT|RGD=71012|UniProtKB=Q08464	Frizzled-2	ISS	8717036	PubMed	PTHR11309:SF34	FRIZZLED-2
P00048	PI3 kinase pathway	P01189	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P05917	Opioid proopiomelanocortin pathway	P06004	Mu or Delta receptor	HUMAN|HGNC=8153|UniProtKB=P41143	Delta-type opioid receptor	RCA	11259498	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P04393	Ras Pathway	P04573	Elk-1	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	9644975	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00005	Angiogenesis	P00219	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00052	TGF-beta signaling pathway	P01279	Smurfs	MACMU|Ensembl=ENSMMUG00000009183|UniProtKB=F7HPB2	Uncharacterized protein	ISS	11252892	PubMed	PTHR11254:SF293	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	PSEAE|EnsemblGenome=PA3807|UniProtKB=Q59636	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_116948|UniProtKB=C3YKS6	Putative uncharacterized protein	ISS			PTHR11937:SF359	SUBFAMILY NOT NAMED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	LEIMA|EnsemblGenome=LmjF.04.1230|UniProtKB=Q9U1E8	Actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00919	Arf6	XENTR|Xenbase=XB-GENE-967358|UniProtKB=F6V4X2	Uncharacterized protein (Fragment)	ISS	11752622	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00005	Angiogenesis	P00203	Erk	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	DROME|FlyBase=FBgn0032151|UniProtKB=Q7KTF8	Nicotinic acetylcholine receptor alpha6, isoform E	IC	85270494	PubMed	PTHR18945:SF763	NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA6, ISOFORM E
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	MOUSE|MGI=MGI=1921575|UniProtKB=Q6IRU5	Clathrin light chain B	ISS	9388255	PubMed	PTHR10639:SF2	CLATHRIN LIGHT CHAIN B
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06758	DRD2	MOUSE|MGI=MGI=94924|UniProtKB=P61168	D(2) dopamine receptor	RCA	2137198	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P02757	O-antigen biosynthesis	P03045	dTDP-glucose 4,6-dehydratase	ARATH|TAIR=AT1G78570|UniProtKB=Q9SYM5	Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM1	ISS			PTHR43000:SF8	TRIFUNCTIONAL UDP-GLUCOSE 4,6-DEHYDRATASE/UDP-4-KETO-6-DEOXY-D-GLUCOSE 3,5-EPIMERASE/UDP-4-KETO-L-RHAMNOSE-REDUCTASE RHM1-RELATED
P02734	Chorismate biosynthesis	P02872	3-Dehydroquinate synthase	DEIRA|EnsemblGenome=DR_0777|UniProtKB=Q9RW92	3-dehydroquinate synthase	ISS			PTHR43622:SF1	3-DEHYDROQUINATE SYNTHASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04453	ACTH	BOVIN|Ensembl=ENSBTAG00000007897|UniProtKB=P01190	Pro-opiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P04393	Ras Pathway	P04572	JNK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	ISS	10514528	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00029	Huntington disease	P00799	JNK-2	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00046	Oxidative stress response	P01135	p38	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	TAS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P02738	De novo purine biosynthesis	P02907	dADP kinase	BACSU|EnsemblGenome=BSU22730|UniProtKB=P31103	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P04393	Ras Pathway	P04574	PLD	MACMU|Ensembl=ENSMMUG00000023289|UniProtKB=F7FFD2	Uncharacterized protein	ISS	10497874	PubMed	PTHR18896:SF57	PHOSPHOLIPASE D1
P04398	p53 pathway feedback loops 2	P04651	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00047	PDGF signaling pathway	P01173	STAT	MONDO|Ensembl=ENSMODG00000014816|UniProtKB=F7CHH2	Signal transducer and activator of transcription	ISS	95236292	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00053	T cell activation	P01330	IKK	CANLF|Ensembl=ENSCAFG00000005526|UniProtKB=E2RKR0	Uncharacterized protein	ISS	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CIOIN|Ensembl=ENSCING00000000848|UniProtKB=F6SCP4	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00805	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00819	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01331	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IDA	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02783	Tryptophan biosynthesis	P03207	Tryptophan synthase A	THEMA|EnsemblGenome=TM_0137|UniProtKB=P50908	Tryptophan synthase alpha chain	ISS			PTHR43455:SF1	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00589	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00985	PDK1/2	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	IDA	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DROME|FlyBase=FBgn0000044|UniProtKB=P53501	Actin-57B	ISS	11889126	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00520	Rho GAPs	CANLF|Ensembl=ENSCAFG00000009147|UniProtKB=A4GT58	Cdc42 GTPase-activating protein	ISS	14724572	PubMed	PTHR23176:SF28	RHO GTPASE-ACTIVATING PROTEIN 1
P00025	Hedgehog signaling pathway	P00692	GSK3	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	IC	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00624	14-3-3	MOUSE|MGI=MGI=109194|UniProtKB=P68510	14-3-3 protein eta	IGI	6756037	gi	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00029	Huntington disease	P00778	NMDA receptor	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00004	Alzheimer disease-presenilin pathway	P00110	Ire-1 N-terminal fragment	PANTR|Ensembl=ENSPTRG00000009535|UniProtKB=H2QDP0	Uncharacterized protein	ISS	10619423	PubMed	PTHR13954:SF17	SERINE/THREONINE-PROTEIN KINASE/ENDORIBONUCLEASE IRE1
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00645	Rac	DICDI|dictyBase=DDB_G0286555|UniProtKB=P34147	Rho-related protein racA	ISS	4757952	gi	PTHR24072:SF183	RHO-RELATED PROTEIN RACA
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	BOVIN|Ensembl=ENSBTAG00000020079|UniProtKB=F1N3T0	Uncharacterized protein	ISS	12052864	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	MACMU|Ensembl=ENSMMUG00000004886|UniProtKB=F7AGT9	Uncharacterized protein	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00057	Wnt signaling pathway	P01457	GBeta	ANOGA|EnsemblGenome=AGAP001506|UniProtKB=Q7PXP3	AGAP001506-PA	ISS	10391901	PubMed	PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CAEEL|WormBase=WBGene00001613|UniProtKB=Q10914	Glutamate receptor 2	IC	http://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF270	GLUTAMATE RECEPTOR 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MOUSE|MGI=MGI=107717|UniProtKB=Q8VDD5	Myosin-9	ISS	89264452	PubMed	PTHR13140:SF317	MYOSIN-9
P00020	FAS signaling pathway	P00615	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	RAT|RGD=1589741|UniProtKB=P56700	Regulator of G-protein signaling 16	ISS	8756726	PubMed	PTHR10845:SF187	REGULATOR OF G-PROTEIN SIGNALING 16
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01219	SAPK	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	ISS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	CHICK|Ensembl=ENSGALG00000015835|UniProtKB=F1NZT2	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00005	Angiogenesis	P00206	Wnt	HUMAN|HGNC=12780|UniProtKB=P09544	Protein Wnt-2	ISS	11266476	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02913	Thymidylate synthase	DEIRA|EnsemblGenome=DR_2630|UniProtKB=Q9RR67	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00048	PI3 kinase pathway	P01188	Gbetagamma	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	CHICK|Ensembl=ENSGALG00000001383|UniProtKB=F1NJL4	Uncharacterized protein	ISS	12441358	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	11956331	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00048	PI3 kinase pathway	P01181	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00034	Integrin signalling pathway	P00923	Arf1	CANLF|Ensembl=ENSCAFG00000010433|UniProtKB=E2RNQ7	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF294	ADP-RIBOSYLATION FACTOR 3
P00029	Huntington disease	P00796	Kainate receptor	MONDO|Ensembl=ENSMODG00000013079|UniProtKB=F7FB74	Uncharacterized protein	ISS	1648176	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00012	Cadherin signaling pathway	P00470	F-actin	RAT|RGD=2025|UniProtKB=P68136	Actin, alpha skeletal muscle	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00047	PDGF signaling pathway	P01174	Rho	BOVIN|Ensembl=ENSBTAG00000011892|UniProtKB=F1MFS4	Uncharacterized protein	ISS			PTHR14166:SF15	SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 1
P00036	Interleukin signaling pathway	P00985	PDK1/2	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	9094314	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02754	Methylcitrate cycle	P03028	Aconitase	CANLF|Ensembl=ENSCAFG00000001786|UniProtKB=E2RMX9	Aconitate hydratase	ISS			PTHR11670:SF32	CYTOPLASMIC ACONITATE HYDRATASE
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	IC	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	7937853	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04396	Vitamin D metabolism and pathway	P04607	FDX	PANTR|Ensembl=ENSPTRG00000004260|UniProtKB=H2Q4Q7	Ferredoxin 1	ISS	2969697	PubMed	PTHR23426:SF26	ADRENODOXIN, MITOCHONDRIAL
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04393	Ras Pathway	P04547	Ras	CHICK|Ensembl=ENSGALG00000006885|UniProtKB=P08642	GTPase HRas	ISS	87226391	PubMed	PTHR24070:SF385	GTPASE HRAS
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06007	alpha-MSH	MACMU|Ensembl=ENSMMUG00000016463|UniProtKB=F7GBI0	Uncharacterized protein	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00012	Cadherin signaling pathway	P00474	Wnt	RAT|RGD=1309574|UniProtKB=D3ZFS0	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF84	PROTEIN WNT-9B
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00037	Ionotropic glutamate receptor pathway	P01005	NR2D	HUMAN|HGNC=4588|UniProtKB=O15399	Glutamate receptor ionotropic, NMDA 2D	ISS	11554549	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	IPI	12701063	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=1351342|UniProtKB=Q3UVX5	Metabotropic glutamate receptor 5	ISS			PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	TAS	12707323	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00052	TGF-beta signaling pathway	P01284	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000002775|UniProtKB=H2RB55	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	DROME|FlyBase=FBgn0038516|UniProtKB=Q9VEJ3	Pyrroline-5-carboxylate reductase	ISS			PTHR11645:SF46	PYRROLINE-5-CARBOXYLATE REDUCTASE
P00034	Integrin signalling pathway	P00927	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	HUMAN|HGNC=2323|UniProtKB=P31327	Carbamoyl-phosphate synthase [ammonia], mitochondrial	ISS			PTHR11405:SF38	CARBAMOYL-PHOSPHATE SYNTHASE  AMMONIA , MITOCHONDRIAL
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	RCA	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	CAEEL|WormBase=WBGene00002173|UniProtKB=Q9Y0A1	Inositol 1,4,5-trisphosphate receptor itr-1	ISS	11007872	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P02721	ATP synthesis	P02794	F1 beta	DAPPU|EnsemblGenome=DAPPUDRAFT_309746|UniProtKB=E9FQP0	ATP synthase subunit beta	ISS	2896550	PubMed	PTHR15184:SF44	ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CHICK|Ensembl=ENSGALG00000008898|UniProtKB=F1P2J9	Uncharacterized protein	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	NEUCR|EnsemblGenome=EFNCRG00000008076|UniProtKB=Q7RVR1	Mitogen-activated protein kinase	ISS			PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00005	Angiogenesis	P00238	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00005	Angiogenesis	P00212	EphR	HUMAN|HGNC=3387|UniProtKB=P29320	Ephrin type-A receptor 3	ISS			PTHR24416:SF18	EPHRIN TYPE-A RECEPTOR 3
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=1310389|UniProtKB=D3ZTF6	Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Predicted), isoform CRA_a	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	MYCTU|EnsemblGenome=Rv2763c|UniProtKB=P9WNX1	Dihydrofolate reductase	ISS			PTHR22778:SF16	DIHYDROFOLATE REDUCTASE
P00005	Angiogenesis	P00255	Notch	CANLF|Ensembl=ENSCAFG00000019633|UniProtKB=F1PDC7	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04395	Vasopressin synthesis	P04594	Neurophysin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00006	Apoptosis signaling pathway	P00260	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01332	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	DICDI|dictyBase=DDB_G0276617|UniProtKB=P42522	Myosin IC heavy chain	IC			PTHR13140:SF663	HEAVY CHAIN, UNCONVENTIONAL MYOSIN
P05916	Opioid prodynorphin pathway	P06002	G-protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	TAS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00561	STAT	HUMAN|HGNC=11364|UniProtKB=P40763	Signal transducer and activator of transcription 3	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	IXOSC|EnsemblGenome=ISCW014459|UniProtKB=B7QIS2	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00049	Parkinson disease	P01236	Casein kinase II	BOVIN|Gene=CSNK2A1|UniProtKB=P68399	Casein kinase II subunit alpha	ISS	10806215	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00005	Angiogenesis	P00200	Dsh	PANTR|Gene=DVL1|UniProtKB=Q5IS48	Segment polarity protein dishevelled homolog DVL-1	ISS	11212302	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P00057	Wnt signaling pathway	P01432	Beta-Catenin	MOUSE|MGI=MGI=88276|UniProtKB=Q02248	Catenin beta-1	IDA	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00011	Blood coagulation	P00409	PAI-2	HUMAN|HGNC=8584|UniProtKB=P05120	Plasminogen activator inhibitor 2	ISS	4505595	gi	PTHR11461:SF61	PLASMINOGEN ACTIVATOR INHIBITOR 2
P00053	T cell activation	P01315	Calcineurin	ORNAN|Ensembl=ENSOANG00000010781|UniProtKB=F6X434	Serine/threonine-protein phosphatase	ISS	12091710	PubMed	PTHR11668:SF186	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT GAMMA ISOFORM
P04393	Ras Pathway	P04547	Ras	CHICK|Ensembl=ENSGALG00000014033|UniProtKB=E1BTS2	Uncharacterized protein	ISS	99084794	PubMed	PTHR24070:SF186	GTPASE KRAS
P00018	EGF receptor signaling pathway	P00561	STAT	HUMAN|HGNC=11364|UniProtKB=P40763	Signal transducer and activator of transcription 3	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	METAC|EnsemblGenome=MA_0179|UniProtKB=Q8TU94	TATA-box-binding protein 2	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00049	Parkinson disease	P01219	SAPK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00005	Angiogenesis	P00219	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	DROME|FlyBase=FBgn0001123|UniProtKB=P20354	G protein alpha s subunit	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01401	HIF-1	HUMAN|HGNC=4910|UniProtKB=Q16665	Hypoxia-inducible factor 1-alpha	IGI	14526383	PubMed	PTHR23043:SF7	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	BOVIN|Ensembl=ENSBTAG00000037985|UniProtKB=F1MCK3	Muscarinic acetylcholine receptor	ISS	11166329	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00006	Apoptosis signaling pathway	P00314	MKK3	HUMAN|HGNC=6843|UniProtKB=P46734	Dual specificity mitogen-activated protein kinase kinase 3	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00047	PDGF signaling pathway	P01142	p90RSK	HUMAN|HGNC=10432|UniProtKB=P51812	Ribosomal protein S6 kinase alpha-3	ISS	2779569	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P04395	Vasopressin synthesis	P04593	Glycopeptide	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	IC	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00054	Toll receptor signaling pathway	P01357	MEKK1	BOVIN|Ensembl=ENSBTAG00000013790|UniProtKB=E1B847	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04393	Ras Pathway	P04556	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	RAT|RGD=2732|UniProtKB=P22756	Glutamate receptor ionotropic, kainate 1	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00029	Huntington disease	P00805	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	RAT|RGD=2155|UniProtKB=O88656	Actin-related protein 2/3 complex subunit 1B	ISS	12963527	gi	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ANOGA|EnsemblGenome=AGAP001676|UniProtKB=Q7PXZ8	AGAP001676-PA	IDA	11889126	PubMed	PTHR11937:SF368	ACTIN, INDIRECT FLIGHT MUSCLE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014262|UniProtKB=F7BYS8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00005	Angiogenesis	P00219	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	MACMU|Ensembl=ENSMMUG00000014817|UniProtKB=F6VXD8	Uncharacterized protein	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00059	p53 pathway	P04635	Sumo-1 ligase	RAT|RGD=621761|UniProtKB=P61959	Small ubiquitin-related modifier 2	ISS			PTHR10562:SF11	SMALL UBIQUITIN-RELATED MODIFIER 2-RELATED
P00045	Notch signaling pathway	P01114	Ntm	HUMAN|HGNC=7882|UniProtKB=Q04721	Neurogenic locus notch homolog protein 2	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00059	p53 pathway	P01486	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00568	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	22533439	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00015	Circadian clock system	P00501	Clock	PANTR|Ensembl=ENSPTRG00000016072|UniProtKB=H2QPH9	Clock homolog	ISS	10198158	PubMed	PTHR23042:SF2	CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT
P00029	Huntington disease	P00778	NMDA receptor	MOUSE|MGI=MGI=95822|UniProtKB=Q01098	Glutamate receptor ionotropic, NMDA 2C	IDA	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05913	Enkephalin release	P05977	G-Protein (s)	ANOGA|EnsemblGenome=AGAP005911|UniProtKB=Q7Q6D4	AGAP005911-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00049	Parkinson disease	P01215	Syntaxin	MACMU|Ensembl=ENSMMUG00000012252|UniProtKB=F7GMG0	Syntaxin-12	ISS	10321247	PubMed	PTHR19957:SF88	SYNTAXIN-12
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01076	CAT	CAEBR|Gene=CBG08305|UniProtKB=A8X694	Protein CBR-CHA-1	ISS	92155737	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P00012	Cadherin signaling pathway	P00467	alpha-catenin	CHICK|Gene=CTNNA2|UniProtKB=P30997	Catenin alpha-2	IDA	9362521	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P00019	Endothelin signaling pathway	P00590	IP3 R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00641	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IGI	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Gene=MYH3|UniProtKB=P02565	Myosin-1B	IEP	10938134	PubMed	PTHR13140:SF657	MYOSIN-4
P00048	PI3 kinase pathway	P01192	p110	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	CHICK|Gene=ODC1|UniProtKB=P27118	Ornithine decarboxylase (Fragment)	ISS			PTHR11482:SF42	ORNITHINE DECARBOXYLASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	MACMU|Ensembl=ENSMMUG00000010122|UniProtKB=F7HF84	Casein kinase I isoform epsilon	ISS	11865049	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04547	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00004	Alzheimer disease-presenilin pathway	P00111	C99	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	CANLF|Ensembl=ENSCAFG00000014736|UniProtKB=F1PGV0	Clathrin heavy chain	ISS	9388255	PubMed	PTHR10292:SF6	CLATHRIN HEAVY CHAIN 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00747	Rhodopsin	ANOGA|EnsemblGenome=AGAP002462|UniProtKB=Q7QC57	AGAP002462-PA	ISS	1634520	PubMed	PTHR24240:SF85	OPSIN RH1-RELATED
P05915	Opioid proenkephalin pathway	P05994	G-protein	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P02778	Sulfate assimilation	P03164	Adenylylsulfate kinase	YEAST|SGD=S000001484|UniProtKB=Q02196	Adenylyl-sulfate kinase	ISS			PTHR11055:SF1	PAPS SYNTHETASE, ISOFORM D
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00036	Interleukin signaling pathway	P00985	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=1890219|UniProtKB=Q99PF4	Cadherin-23	IDA	8120095	PubMed	PTHR43956:SF3	CADHERIN-23
P00037	Ionotropic glutamate receptor pathway	P01015	Glu4	TAKRU|Ensembl=ENSTRUG00000011517|UniProtKB=H2TWL9	Uncharacterized protein (Fragment)	ISS	12871085	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P02747	Histidine biosynthesis	P02985	Histidinol dehydrogenase	THEMA|EnsemblGenome=TM_1041|UniProtKB=Q9X0D1	Histidinol dehydrogenase	ISS			PTHR21256:SF2	HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00922	Collagen	HUMAN|HGNC=2217|UniProtKB=P20849	Collagen alpha-1(IX) chain	IDA	10778855	PubMed	PTHR44652:SF3	COLLAGEN ALPHA-1 IX  CHAIN
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	RCA	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04396	Vitamin D metabolism and pathway	P04604	FdxR	CANLF|Ensembl=ENSCAFG00000004638|UniProtKB=E2RDC3	NADPH:adrenodoxin oxidoreductase, mitochondrial	ISS	2845396	PubMed	PTHR11938:SF91	NADPH:ADRENODOXIN OXIDOREDUCTASE, MITOCHONDRIAL
P00007	Axon guidance mediated by semaphorins	P00340	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00047	PDGF signaling pathway	P01140	ELK	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	ISS	11279280	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00054	Toll receptor signaling pathway	P01375	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000004690|UniProtKB=Q5F3W3	Mitogen-activated protein kinase 6	ISS	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CAEEL|WormBase=WBGene00000064|UniProtKB=P10984	Actin-2	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00038	JAK/STAT signaling pathway	P01027	STAT	HUMAN|HGNC=11367|UniProtKB=P51692	Signal transducer and activator of transcription 5B	ISS	95236292	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	XENTR|Xenbase=XB-GENE-999257|UniProtKB=F7CEX4	Uncharacterized protein	ISS	97228584	PubMed	PTHR11920:SF319	ADENYLATE CYCLASE TYPE 9
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	YEAST|SGD=S000001857|UniProtKB=P02557	Tubulin beta chain	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00018	EGF receptor signaling pathway	P00542	EGFR	HUMAN|HGNC=3236|UniProtKB=P00533	Epidermal growth factor receptor	ISS	21100872	PubMed	PTHR24416:SF91	EPIDERMAL GROWTH FACTOR RECEPTOR
P00005	Angiogenesis	P00220	c-Jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04393	Ras Pathway	P04569	Cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P02772	Pyruvate metabolism	P03132	Pyruvate Kinase	ARATH|TAIR=AT5G63680|UniProtKB=Q9FFP6	Pyruvate kinase	TAS	15242863	gi	PTHR11817:SF3	AT14039P-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	1650351	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	HUMAN|HGNC=20778|UniProtKB=P07437	Tubulin beta chain	ISS	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P04393	Ras Pathway	P04557	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00046	Oxidative stress response	P01138	MKK4	MACMU|Ensembl=ENSMMUG00000019842|UniProtKB=F7FU91	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	IC	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00049	Parkinson disease	P01212	p38 MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01440	Cadherin	CAEEL|WormBase=WBGene00001980|UniProtKB=Q967F4	Cadherin-related hmr-1	IDA	8120095	PubMed	PTHR24026:SF69	PROTOCADHERIN FAT 4
P05916	Opioid prodynorphin pathway	P06002	G-protein	CHICK|Ensembl=ENSGALG00000027629|UniProtKB=Q5ZJ03	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00047	PDGF signaling pathway	P01170	PDGF	CANLF|Gene=PDGFB|UniProtKB=Q6Q7I7	Platelet-derived growth factor subunit B	ISS			PTHR11633:SF2	PLATELET-DERIVED GROWTH FACTOR SUBUNIT B
P00029	Huntington disease	P00796	Kainate receptor	RAT|RGD=2734|UniProtKB=Q01812	Glutamate receptor ionotropic, kainate 4	IDA	12871085	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05731	GABA-B receptor II signaling	P05755	Gbeta	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00048	PI3 kinase pathway	P01182	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00018	EGF receptor signaling pathway	P00547	PP2A	MACMU|Ensembl=ENSMMUG00000008205|UniProtKB=F7GWP9	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	ISS	10092233	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00029	Huntington disease	P00790	beta-Tubulin	ORYSJ|EnsemblGenome=OS01G0805900|UniProtKB=P45960	Tubulin beta-4 chain	TAS	9454836	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00034	Integrin signalling pathway	P00936	PI3K	CANAL|CGD=CAL0068551|UniProtKB=Q5AAR9	Phosphatidylinositol 3-kinase	IC	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00021	FGF signaling pathway	P00626	Spry	MOUSE|MGI=MGI=1345139|UniProtKB=Q9QXV9	Protein sprouty homolog 1	IGI	12882970	PubMed	PTHR12365:SF10	PROTEIN SPROUTY HOMOLOG 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00059	p53 pathway	P04625	Cdk2	HUMAN|HGNC=1771|UniProtKB=P24941	Cyclin-dependent kinase 2	ISS	15660127	PubMed	PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00047	PDGF signaling pathway	P01172	c-Myc	HUMAN|HGNC=7554|UniProtKB=Q99417	C-Myc-binding protein	ISS	15094771	PubMed	PTHR13168:SF0	C-MYC-BINDING PROTEIN
P00059	p53 pathway	P04609	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00025	Hedgehog signaling pathway	P00683	Slimb	PANTR|Ensembl=ENSPTRG00000017526|UniProtKB=H2QS02	Uncharacterized protein	ISS	12628165	PubMed	PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P00021	FGF signaling pathway	P00638	PLCgamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00053	T cell activation	P01318	PKC-theta	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IGI	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	ORNAN|Ensembl=ENSOANG00000013961|UniProtKB=F6VPY1	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00029	Huntington disease	P00811	Arp2/3 complex	ORNAN|Ensembl=ENSOANG00000000999|UniProtKB=F6WN02	Actin-related protein 2/3 complex subunit 5	ISS	12932731	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P05915	Opioid proenkephalin pathway	P05985	Mu or Delta receptor	MACMU|Ensembl=ENSMMUG00000009389|UniProtKB=F7HEV7	Uncharacterized protein	ISS	12093103	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00053	T cell activation	P01332	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04393	Ras Pathway	P04570	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00054	Toll receptor signaling pathway	P01368	MKK2	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00049	Parkinson disease	P01223	UbcH8	DROME|FlyBase=FBgn0026316|UniProtKB=Q7K738	EG:52C10.4 protein	IDA			PTHR24068:SF116	AT26201P-RELATED
P02734	Chorismate biosynthesis	P02869	3-Dehydroquinate dehydratase	DEIRA|EnsemblGenome=DR_0778|UniProtKB=Q9RW91	3-dehydroquinate dehydratase	ISS			PTHR21272:SF3	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00775	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	TAS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000022550|UniProtKB=F6Y9I6	Serine/threonine-protein kinase	ISS	8078925	PubMed	PTHR22968:SF9	SERINE/THREONINE-PROTEIN KINASE D1
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00025	Hedgehog signaling pathway	P00691	CBP	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	CANLF|Ensembl=ENSCAFG00000000676|UniProtKB=E2RSE5	Uncharacterized protein	ISS	9718352	PubMed	PTHR11647:SF50	DIHYDROPYRIMIDINASE
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P06587	Nicotine pharmacodynamics pathway	P06595	CHRNA3	BOVIN|Gene=CHRNA3|UniProtKB=Q07263	Neuronal acetylcholine receptor subunit alpha-3	ISS	18005395	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P00009	Axon guidance mediated by netrin	P00357	Netrin	MOUSE|MGI=MGI=1934028|UniProtKB=Q8R4G0	Netrin-G1	ISS			PTHR10574:SF28	NETRIN-G1
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	IPI	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BOVIN|Ensembl=ENSBTAG00000014614|UniProtKB=P62739	Actin, aortic smooth muscle	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00047	PDGF signaling pathway	P01164	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	12855688	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P02779	Thiamin biosynthesis	P03175	1-Deoxyxylulose-5-phosphate synthase	PLAF7|EnsemblGenome=MAL13P1.186|UniProtKB=Q8IDW0	1-deoxy-D-xylulose 5-phosphate synthase	ISS			PTHR43322:SF5	1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE 1-RELATED
P00021	FGF signaling pathway	P00634	MEKK1-5	RAT|RGD=620967|UniProtKB=F1M9D0	Protein Map3k2	ISS	8649450	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P02723	Adenine and hypoxanthine salvage pathway	P02811	Adenosine deaminase	MOUSE|MGI=MGI=87916|UniProtKB=P03958	Adenosine deaminase	ISS			PTHR11409:SF43	ADENOSINE DEAMINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00047	PDGF signaling pathway	P01173	STAT	RAT|RGD=3772|UniProtKB=P52631	Signal transducer and activator of transcription 3	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P02772	Pyruvate metabolism	P03134	Aminotransefrase	PSEAE|EnsemblGenome=PA0132|UniProtKB=Q9I700	Beta-alanine--pyruvate aminotransferase	ISS	10984043	PubMed	PTHR42684:SF1	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00206	Wnt	HUMAN|HGNC=12787|UniProtKB=P56706	Protein Wnt-7b	ISS	8717036	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	HUMAN|HGNC=5295|UniProtKB=P28335	5-hydroxytryptamine receptor 2C	IDA			PTHR24247:SF32	5-HYDROXYTRYPTAMINE RECEPTOR 2C
P00049	Parkinson disease	P01211	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	IDA	9603989	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01173	STAT	RAT|RGD=3772|UniProtKB=P52631	Signal transducer and activator of transcription 3	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	TAS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00036	Interleukin signaling pathway	P00976	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	HUMAN|HGNC=6696|UniProtKB=O75096	Low-density lipoprotein receptor-related protein 4	IDA	11907044	PubMed	PTHR44017:SF4	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4
P00010	B cell activation	P00372	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12748278	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	MOUSE|MGI=MGI=97838|UniProtKB=Q8CGC7	Bifunctional glutamate/proline--tRNA ligase	ISS			PTHR43382:SF2	BIFUNCTIONAL GLUTAMATE/PROLINE--TRNA LIGASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MACMU|Ensembl=ENSMMUG00000010184|UniProtKB=F6SR09	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01443	Phospholipase C	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IDA	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000008368|UniProtKB=F7CX62	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF61	PROTOCADHERIN BETA-13
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	TAS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00297	NFkappaB	MOUSE|MGI=MGI=97897|UniProtKB=P15307	Proto-oncogene c-Rel	IDA	9480976	PubMed	PTHR24169:SF4	PROTO-ONCOGENE C-REL
P00005	Angiogenesis	P00238	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P06959	CCKR signaling map	P07233	MAP2K6	HUMAN|HGNC=6846|UniProtKB=P52564	Dual specificity mitogen-activated protein kinase kinase 6	RCA	12239223	PubMed	PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P05913	Enkephalin release	P05974	G-Protein (i)	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00020	FAS signaling pathway	P00596	Caspase6	DROME|FlyBase=FBgn0028381|UniProtKB=Q9VET9	AT03047p	IGI	11463840	PubMed	PTHR10454:SF205	AT03047P
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00464	Fyn	HUMAN|HGNC=4037|UniProtKB=P06241	Tyrosine-protein kinase Fyn	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00017	DNA replication	P00536	DNA Topisomerase	CHICK|Gene=TOP2B|UniProtKB=O42131	DNA topoisomerase 2-beta	ISS			PTHR10169:SF36	DNA TOPOISOMERASE 2-BETA
P00006	Apoptosis signaling pathway	P00260	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	9199552	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	CIOIN|Ensembl=ENSCING00000001821|UniProtKB=Q9NL43	Glycogen synthase kinase	TAS			PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05913	Enkephalin release	P05972	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00049	Parkinson disease	P01208	Hsp70	DEIRA|EnsemblGenome=DR_0129|UniProtKB=Q9RY23	Chaperone protein DnaK	IDA	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CHICK|Ensembl=ENSGALG00000009621|UniProtKB=P60706	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P02738	De novo purine biosynthesis	P02892	5-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase	ARATH|TAIR=AT1G36280|UniProtKB=Q8GUN7	Adenylosuccinate lyase	ISS			PTHR43411:SF1	ADENYLOSUCCINATE LYASE
P04398	p53 pathway feedback loops 2	G04711	SIAH-1	BOVIN|Ensembl=ENSBTAG00000010868|UniProtKB=F1N5G3	E3 ubiquitin-protein ligase	ISS	14985507	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	HUMAN|HGNC=6266|UniProtKB=P48544	G protein-activated inward rectifier potassium channel 4	ISS	12374786	PubMed	PTHR11767:SF52	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 4
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	11313908	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P02734	Chorismate biosynthesis	P02873	Shikimate dehydrogenase	ECOLI|EcoGene=EG10077|UniProtKB=P15770	Shikimate dehydrogenase (NADP(+))	ISS			PTHR21089:SF1	BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE/SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC
P05731	GABA-B receptor II signaling	P05755	Gbeta	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00029	Huntington disease	P00807	Actin	ARATH|TAIR=AT3G46520|UniProtKB=P53497	Actin-12	IDA	14684598	PubMed	PTHR11937:SF276	ACTIN-12
P00053	T cell activation	P01322	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00048	PI3 kinase pathway	P01199	Galpha	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02781	Threonine biosynthesis	P03190	Threonine synthase	PANTR|Ensembl=ENSPTRG00000002368|UniProtKB=H2Q1Q9	Uncharacterized protein	ISS			PTHR43515:SF1	THREONINE SYNTHASE-LIKE 1
P00021	FGF signaling pathway	P00644	p38	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	IGI	20451058	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00048	PI3 kinase pathway	P01185	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00057	Wnt signaling pathway	P01428	Frizzled	DANRE|ZFIN=ZDB-GENE-990415-220|UniProtKB=Q9W6E3	Frizzled homolog 10	IDA	11212302	PubMed	PTHR11309:SF86	FRIZZLED-10
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8971|UniProtKB=O00443	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00053	T cell activation	P01312	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IDA	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00010	B cell activation	P00385	Rac	MACMU|Ensembl=ENSMMUG00000021075|UniProtKB=F7GY91	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	BOVIN|Ensembl=ENSBTAG00000000820|UniProtKB=Q5E9F0	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	ISS	2122451	PubMed	PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DROME|FlyBase=FBgn0024846|UniProtKB=O61443	Mitogen-activated protein kinase 14B	IDA	10851062	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04393	Ras Pathway	P04547	Ras	MONDO|Gene=KRAS|UniProtKB=Q07983	GTPase KRas	ISS	9869449	PubMed	PTHR24070:SF186	GTPASE KRAS
P02754	Methylcitrate cycle	P03027	2-methylisocitrate lyase	ECOLI|EcoGene=EG13601|UniProtKB=P77541	2-methylisocitrate lyase	ISS			PTHR42905:SF5	2-METHYLISOCITRATE LYASE
P00018	EGF receptor signaling pathway	P00539	14-3-3	HUMAN|HGNC=12854|UniProtKB=P27348	14-3-3 protein theta	IGI	10407019	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P00019	Endothelin signaling pathway	P00570	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	2372396	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P06664	Gonadotropin-releasing hormone receptor pathway	P06849	Sos	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	RCA	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04398	p53 pathway feedback loops 2	P04657	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	HUMAN|HGNC=15781|UniProtKB=Q494W8	CHRNA7-FAM7A fusion protein	ISS	85270494	PubMed	PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Ensembl=ENSCAFG00000013755|UniProtKB=Q49LX5	Somatostatin receptor type 1	ISS	12562507	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TAKRU|Ensembl=ENSTRUG00000014318|UniProtKB=H2UI49	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00018	EGF receptor signaling pathway	P00552	Ras	DANRE|ZFIN=ZDB-GENE-990415-166|UniProtKB=P79737	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00045	Notch signaling pathway	P01113	Pen-2	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00009	Axon guidance mediated by netrin	P00359	NFAT	BOVIN|Ensembl=ENSBTAG00000018270|UniProtKB=F1MGR9	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	BOVIN|Ensembl=ENSBTAG00000034854|UniProtKB=F1N246	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	MOUSE|MGI=MGI=1201678|UniProtKB=Q5SUF7	Protein Cacna1g	ISS	14526084	PubMed	PTHR10037:SF137	VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1G
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00049	Parkinson disease	P01212	p38 MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P06664	Gonadotropin-releasing hormone receptor pathway	P06841	gnaq/11	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	RCA	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01443	Phospholipase C	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00005	Angiogenesis	P00219	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P04398	p53 pathway feedback loops 2	P04657	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	ECOLI|EcoGene=EG10383|UniProtKB=P0A9C5	Glutamine synthetase	ISS			PTHR43407:SF1	LENGSIN
P00005	Angiogenesis	P00224	PDGF	BOVIN|Ensembl=ENSBTAG00000034827|UniProtKB=A4IFC0	PDGFD protein	ISS	12629513	PubMed	PTHR11633:SF4	PLATELET-DERIVED GROWTH FACTOR D
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	MACMU|Ensembl=ENSMMUG00000020134|UniProtKB=F6U055	Uncharacterized protein	ISS	11266476	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MONDO|Ensembl=ENSMODG00000020204|UniProtKB=F6SED9	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00053	T cell activation	P01305	Calmodulin	BRAFL|Gene=BRAFLDRAFT_124869|UniProtKB=C3ZEW0	Putative uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF263	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01451	Galpha	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MOUSE|MGI=MGI=108520|UniProtKB=Q61088	Frizzled-4	TAS	11212302	PubMed	PTHR11309:SF23	FRIZZLED-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00010	B cell activation	P00373	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01452	NFAT	RAT|RGD=1308692|UniProtKB=A0A0G2JTY4	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 (Predicted), isoform CRA_b	ISS	12015605	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	ISS	14744463	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00023	General transcription regulation	P00668	TFIIB	MOUSE|MGI=MGI=1919558|UniProtKB=Q8CFK2	Transcription factor IIIB 90 kDa subunit	ISS			PTHR11618:SF4	TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=1351340|UniProtKB=Q9QYS2	Metabotropic glutamate receptor 3	IDA	12488551	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00016	Cytoskeletal regulation by Rho GTPase	P00510	mDia	RAT|RGD=1310707|UniProtKB=F1M775	Protein Diaph1	ISS			PTHR23213:SF17	PROTEIN DIAPHANOUS HOMOLOG 1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CHICK|Ensembl=ENSGALG00000007447|UniProtKB=P09207	Tubulin beta-6 chain	ISS	12932731	PubMed	PTHR11588:SF112	TUBULIN BETA-1 CHAIN
P00018	EGF receptor signaling pathway	P00564	Rac	ARATH|TAIR=AT5G62880|UniProtKB=O82481	Rac-like GTP-binding protein ARAC10	ISS			PTHR24072:SF255	RAC-LIKE GTP-BINDING PROTEIN ARAC10-RELATED
P00056	VEGF signaling pathway	P01425	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P02749	Leucine biosynthesis	P02999	2-Isopropylmalate synthase	BACTN|EnsemblGenome=BT_1861|UniProtKB=Q8A6L6	2-isopropylmalate synthase	ISS			PTHR10277:SF9	2-ISOPROPYLMALATE SYNTHASE 1, CHLOROPLASTIC-RELATED
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	XENTR|Xenbase=XB-GENE-854877|UniProtKB=F7C949	Presenilin	ISS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P02775	Salvage pyrimidine ribonucleotides	P03153	Cytidylate kinase	RAT|RGD=1303144|UniProtKB=Q68FP8	Adenylate kinase 8	ISS			PTHR23359:SF102	ADENYLATE KINASE 8
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00016	Cytoskeletal regulation by Rho GTPase	P00508	Cofilin	BOVIN|Ensembl=ENSBTAG00000015053|UniProtKB=Q148F1	Cofilin-2	ISS			PTHR11913:SF15	COFILIN-2
P00057	Wnt signaling pathway	P01465	Ggamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01098	CHT1	HUMAN|HGNC=14025|UniProtKB=Q9GZV3	High affinity choline transporter 1	RCA			PTHR11819:SF129	HIGH AFFINITY CHOLINE TRANSPORTER 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	YEAST|SGD=S000006124|UniProtKB=P06245	cAMP-dependent protein kinase type 2	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MOUSE|MGI=MGI=1930076|UniProtKB=Q9Z2B9	Ribosomal protein S6 kinase alpha-4	ISS	9792677	PubMed	PTHR24351:SF41	RIBOSOMAL PROTEIN S6 KINASE ALPHA-4
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00009	Axon guidance mediated by netrin	P00364	cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00010	B cell activation	P00383	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IDA	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05913	Enkephalin release	P05974	G-Protein (i)	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00057	Wnt signaling pathway	P01435	SWI/SNF	YEAST|SGD=S000002742|UniProtKB=Q05471	Helicase SWR1	IDA	11532957	PubMed	PTHR10799:SF832	HELICASE DOMINO
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	PANTR|Ensembl=ENSPTRG00000014576|UniProtKB=H2QLZ9	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00018	EGF receptor signaling pathway	P00562	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IGI	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	STRPU|EnsemblGenome=SPU_018419|UniProtKB=W4YRI6	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01203	p101	CANLF|Ensembl=ENSCAFG00000017387|UniProtKB=E2RLD1	Uncharacterized protein	ISS	129387	gi	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PANTR|Ensembl=ENSPTRG00000006890|UniProtKB=H2Q943	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	HUMAN|HGNC=5302|UniProtKB=P34969	5-hydroxytryptamine receptor 7	IDA	12181435	PubMed	PTHR24247:SF116	5-HYDROXYTRYPTAMINE RECEPTOR 7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	HUMAN|HGNC=143|UniProtKB=P68032	Actin, alpha cardiac muscle 1	IC	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	MACMU|Ensembl=ENSMMUG00000015381|UniProtKB=F6SFG7	Uncharacterized protein	ISS	6287573	PubMed	PTHR24070:SF186	GTPASE KRAS
P00052	TGF-beta signaling pathway	P01286	TGFbeta	BRAFL|Gene=BRAFLDRAFT_129112|UniProtKB=C3Z3V6	Putative uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF234	PROTEIN DECAPENTAPLEGIC
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000001962|UniProtKB=F6V2H6	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	HUMAN|HGNC=4583|UniProtKB=Q16478	Glutamate receptor ionotropic, kainate 5	ISS	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IDA	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DANRE|ZFIN=ZDB-GENE-000329-1|UniProtKB=Q7ZVI7	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00049	Parkinson disease	P01238	14-3-3	CRYNJ|EnsemblGenome=CNL03930|UniProtKB=Q5K8Z6	14-3-3 protein, putative	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00036	Interleukin signaling pathway	P00968	Ikk	PANTR|Ensembl=ENSPTRG00000033948|UniProtKB=H2RBD4	Conserved helix-loop-helix ubiquitous kinase	ISS	12813046	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P06959	CCKR signaling map	G06969	HDC	HUMAN|HGNC=4855|UniProtKB=P19113	Histidine decarboxylase	RCA	9341140	PubMed	PTHR11999:SF68	HISTIDINE DECARBOXYLASE
P02776	Serine glycine biosynthesis	P03157	Phosphoserine aminotransferase	ECOLI|EcoGene=EG10946|UniProtKB=P23721	Phosphoserine aminotransferase	ISS	11206551	PubMed	PTHR43247:SF2	PHOSPHOSERINE AMINOTRANSFERASE
P00052	TGF-beta signaling pathway	P01284	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00003	Alzheimer disease-amyloid secretase pathway	P00079	alpha7 nicotinic acetylcholine receptor	MOUSE|MGI=MGI=99779|UniProtKB=P49582	Neuronal acetylcholine receptor subunit alpha-7	IDA	11404397	PubMed	PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P00021	FGF signaling pathway	P00636	FGFR1-4	MOUSE|MGI=MGI=95525|UniProtKB=Q03142	Fibroblast growth factor receptor 4	IGI	92146274	PubMed	PTHR24416:SF343	FIBROBLAST GROWTH FACTOR RECEPTOR 4
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	CHICK|Ensembl=ENSGALG00000009320|UniProtKB=Q4JIM4	Presenilin-1	TAS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00010	B cell activation	P00397	IKK	BOVIN|Ensembl=ENSBTAG00000007599|UniProtKB=Q95KV0	Inhibitor of nuclear factor kappa-B kinase subunit beta	IGI	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MONDO|Ensembl=ENSMODG00000010505|UniProtKB=F7E9U1	Uncharacterized protein (Fragment)	ISS	8717036	PubMed	PTHR11309:SF81	FRIZZLED-1
P00034	Integrin signalling pathway	P00912	Arp2/3	MACMU|Ensembl=ENSMMUG00000001458|UniProtKB=F7BKH1	Uncharacterized protein	ISS	9618202	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00009	Axon guidance mediated by netrin	P00360	DCC/UNC-40	MOUSE|MGI=MGI=94869|UniProtKB=P70211	Netrin receptor DCC	IDA	12798294	PubMed	PTHR44146:SF3	NETRIN RECEPTOR DCC
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00057	Wnt signaling pathway	P01451	Galpha	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	IDA	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	MOUSE|MGI=MGI=96610|UniProtKB=P09055	Integrin beta-1	ISS	3487386	PubMed	PTHR10082:SF28	INTEGRIN BETA-1
P00029	Huntington disease	P00775	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12874273	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DANRE|ZFIN=ZDB-GENE-030131-55|UniProtKB=Q6XNL8	Actin	IC	10974003	PubMed	PTHR11937:SF263	ACTIN
P00047	PDGF signaling pathway	P01160	IP3 receptor	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00005	Angiogenesis	P00238	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P00048	PI3 kinase pathway	P01179	PKB	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P05731	GABA-B receptor II signaling	P05760	AC	MOUSE|MGI=MGI=99674|UniProtKB=Q91WF3	Adenylate cyclase type 4	RCA	9870949	PubMed	PTHR11920:SF286	ADENYLATE CYCLASE TYPE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-1712|UniProtKB=Q6PBY0	Guanine nucleotide binding protein (G protein), beta 5	ISS	11313908	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02763	Peptidoglycan biosynthesis	P03086	N-acetylglucosamine-1-phosphate uridyltransferase	AQUAE|EnsemblGenome=aq_607|UniProtKB=O66863	Bifunctional protein GlmU	ISS			PTHR43584:SF3	BIFUNCTIONAL PROTEIN GLMU
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05915	Opioid proenkephalin pathway	P05994	G-protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	ISS	11535291	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00010	B cell activation	P00401	jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00054	Toll receptor signaling pathway	P01358	ERK1	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MONDO|Gene=KRAS|UniProtKB=Q07983	GTPase KRas	ISS	9869449	PubMed	PTHR24070:SF186	GTPASE KRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00021	FGF signaling pathway	P00627	ERK1-2	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	CAEEL|WormBase=WBGene00002232|UniProtKB=O17798	Furin-like protease kpc-1	IDA	10956649	PubMed	PTHR42884:SF3	FURIN-LIKE PROTEASE 1, ISOFORMS 1/1-X/2
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ARATH|TAIR=AT2G42880|UniProtKB=Q9SJG9	Mitogen-activated protein kinase 20	IDA	10514528	PubMed	PTHR24055:SF158	MITOGEN-ACTIVATED PROTEIN KINASE 20
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DANRE|ZFIN=ZDB-GENE-000329-3|UniProtKB=Q7ZVF9	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	RCA	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000009626|UniProtKB=F6ZYQ0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P05916	Opioid prodynorphin pathway	P06002	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00046	Oxidative stress response	P01129	JNK1/2	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00012	Cadherin signaling pathway	P00470	F-actin	PANTR|Ensembl=ENSPTRG00000002086|UniProtKB=H2Q1A9	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04397	p53 pathway by glucose deprivation	P04641	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P05918	p38 MAPK pathway	P06037	TAK1	MACMU|Ensembl=ENSMMUG00000006512|UniProtKB=F7H6S1	Mitogen-activated protein kinase kinase kinase 7 isoform B	ISS	10683140	PubMed	PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000010612|UniProtKB=E1C6T4	Serine/threonine-protein kinase	ISS	12676944	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00036	Interleukin signaling pathway	P00990	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00976	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8674|UniProtKB=Q9Y5H6	Protocadherin alpha-8	IDA	8120095	PubMed	PTHR24028:SF147	PROTOCADHERIN ALPHA-8
P00038	JAK/STAT signaling pathway	P01027	STAT	MOUSE|MGI=MGI=103034|UniProtKB=P52633	Signal transducer and transcription activator 6	ISS	12039028	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00990	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04398	p53 pathway feedback loops 2	P04650	WIP-1	HUMAN|HGNC=9277|UniProtKB=O15297	Protein phosphatase 1D	ISS			PTHR13832:SF359	PROTEIN PHOSPHATASE 1D
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00047	PDGF signaling pathway	P01153	GSK3	PANTR|Ensembl=ENSPTRG00000011049|UniProtKB=H2QGF9	Glycogen synthase kinase 3 alpha	ISS	11995474	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P02738	De novo purine biosynthesis	P02894	IMP cyclohydrolase	PANTR|Ensembl=ENSPTRG00000012891|UniProtKB=H2R0X5	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95818|UniProtKB=Q61626	Glutamate receptor ionotropic, kainate 5	ISS	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00057	Wnt signaling pathway	P01465	Ggamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	RAT|RGD=61863|UniProtKB=P19493	Glutamate receptor 4	ISS	12941441	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00019	Endothelin signaling pathway	P00587	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00269	MAPK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	ISS	94131269	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P02743	Formyltetrahydroformate biosynthesis	P02954	Thymidylate synthase	FUSNN|EnsemblGenome=FN0240|UniProtKB=Q8RGP6	Thymidylate synthase	ISS			PTHR11548:SF1	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000022936|UniProtKB=F6U709	Uncharacterized protein	ISS	11861492	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00020	FAS signaling pathway	P00615	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00011	Blood coagulation	P00415	Plasmin	MACMU|Gene=PLG|UniProtKB=P12545	Plasminogen	ISS	2318848	PubMed	PTHR24261:SF6	PLASMINOGEN
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00036	Interleukin signaling pathway	P00968	Ikk	RAT|RGD=621375|UniProtKB=Q9QY78	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01163	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00010	B cell activation	P00402	Jnk	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00047	PDGF signaling pathway	P01174	Rho	PANTR|Ensembl=ENSPTRG00000005170|UniProtKB=H2R1I1	SLIT-ROBO Rho GTPase activating protein 1	ISS			PTHR14166:SF15	SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 1
P00057	Wnt signaling pathway	P01438	PP2A	BOVIN|Ensembl=ENSBTAG00000007061|UniProtKB=Q08DP7	Protein phosphatase 2, regulatory subunit B', beta isoform	ISS	10092233	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01284	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00034	Integrin signalling pathway	P00922	Collagen	CANLF|Gene=COL1A2|UniProtKB=O46392	Collagen alpha-2(I) chain	IDA	10778855	PubMed	PTHR24023:SF568	COLLAGEN ALPHA-2 I  CHAIN
P00047	PDGF signaling pathway	P01161	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05754	Ggamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00047	PDGF signaling pathway	P01142	p90RSK	HUMAN|HGNC=10436|UniProtKB=P23443	Ribosomal protein S6 kinase beta-1	ISS	11861821	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	FUSNN|EnsemblGenome=FN0102|UniProtKB=Q8RH18	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PLAF7|EnsemblGenome=PFB0480w|UniProtKB=O96189	Qa-SNARE protein	IC			PTHR19957:SF41	SYNTAXIN-1A
P00049	Parkinson disease	P01238	14-3-3	PANTR|Ensembl=ENSPTRG00000013529|UniProtKB=H2R8X6	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00010	B cell activation	P00379	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00036	Interleukin signaling pathway	P00968	Ikk	MOUSE|MGI=MGI=99484|UniProtKB=Q60680	Inhibitor of nuclear factor kappa-B kinase subunit alpha	ISS	12235208	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DROME|FlyBase=FBgn0013343|UniProtKB=Q24547	Syntaxin-1A	ISS	12624525	PubMed	PTHR19957:SF41	SYNTAXIN-1A
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	RAT|RGD=619966|UniProtKB=F1LQT1	Adenylate cyclase 7	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00052	TGF-beta signaling pathway	P01275	P38	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	8925912	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00012	Cadherin signaling pathway	P00470	F-actin	DAPPU|EnsemblGenome=DAPPUDRAFT_228751|UniProtKB=E9HGF5	Cytoplasmatic actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	P01428	Frizzled	PANTR|Ensembl=ENSPTRG00000028511|UniProtKB=H2R570	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF81	FRIZZLED-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00048	PI3 kinase pathway	P01179	PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00402	Jnk	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05913	Enkephalin release	P05975	GPCR (s)	MOUSE|MGI=MGI=97441|UniProtKB=P42866	Mu-type opioid receptor	ISS	11259487	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	TAS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	MACMU|Ensembl=ENSMMUG00000018375|UniProtKB=F7H1D5	Neurogenic locus notch homolog protein 2 isoform 1 preproprotein	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00010	B cell activation	P00392	I kappa B	BOVIN|Ensembl=ENSBTAG00000014492|UniProtKB=Q5EAC4	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1	ISS	10811867	PubMed	PTHR15263:SF1	NF-KAPPA-B INHIBITOR-LIKE PROTEIN 1
P00005	Angiogenesis	P00206	Wnt	DANRE|ZFIN=ZDB-GENE-081006-1|UniProtKB=F1Q9W3	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00023	General transcription regulation	P00660	RNA Polymerase II	TAKRU|Ensembl=ENSTRUG00000008482|UniProtKB=H2T992	Uncharacterized protein	ISS	6522685	gi	PTHR10773:SF12	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	CAEEL|WormBase=WBGene00000913|UniProtKB=G5EE01	DAF-18	ISS	9885576	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04393	Ras Pathway	P04569	Cdc42	BRAFL|Gene=BRAFLDRAFT_122664|UniProtKB=C3ZIB9	Putative uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00034	Integrin signalling pathway	P00927	Rac	ENTHI|EnsemblGenome=EHI_197840|UniProtKB=C4M8K6	Rho family GTPase	IGI	97082968	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P04371	5-Hydroxytryptamine biosynthesis	P04399	Tryptophan hydroxylase	XENTR|Xenbase=XB-GENE-996926|UniProtKB=F6ZR26	Uncharacterized protein (Fragment)	ISS	14597720	PubMed	PTHR11473:SF23	TRYPTOPHAN 5-HYDROXYLASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	CHICK|Ensembl=ENSGALG00000006576|UniProtKB=E1BUE5	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04375	5HT3 type receptor mediated signaling pathway	P04425	K+ channel	RAT|RGD=61997|UniProtKB=O54912	Potassium channel subfamily K member 3	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00402	Jnk	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	DANRE|ZFIN=ZDB-GENE-030131-8783|UniProtKB=Q52WY2	Ras-like protein Cdc42a	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00029	Huntington disease	P00778	NMDA receptor	RAT|RGD=2740|UniProtKB=Q62645	Glutamate receptor ionotropic, NMDA 2D	IDA	14698601	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P02746	Heme biosynthesis	P02982	Protoheme IX farnesyl transferase	PANTR|Ensembl=ENSPTRG00000008790|UniProtKB=H2QCB0	Protoheme IX farnesyltransferase, mitochondrial	ISS			PTHR43448:SF2	PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL
P00029	Huntington disease	G01531	BDNF	DANRE|ZFIN=ZDB-GENE-000412-1|UniProtKB=Q6NZ01	Bdnf protein	IDA	11724916	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00021	FGF signaling pathway	P00632	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00629	PP2A	RAT|RGD=3380|UniProtKB=P63331	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	PANTR|Ensembl=ENSPTRG00000033764|UniProtKB=H2R1H0	Syntaxin 6	ISS	10839363	PubMed	PTHR19957:SF104	SYNTAXIN-6
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	SCHPO|PomBase=SPAC22F8.11|UniProtKB=P40977	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P04398	p53 pathway feedback loops 2	G04708	WIP-1	MACMU|Ensembl=ENSMMUG00000018049|UniProtKB=F7HUA9	Uncharacterized protein	ISS			PTHR13832:SF359	PROTEIN PHOSPHATASE 1D
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	ISS	8170357	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00047	PDGF signaling pathway	P01153	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00021	FGF signaling pathway	P00629	PP2A	CHICK|Ensembl=ENSGALG00000007565|UniProtKB=F1NS72	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B	ISS	1849734	PubMed	PTHR11871:SF1	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	IC	http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00047	PDGF signaling pathway	P01160	IP3 receptor	CAEBR|Gene=CBG_05938|UniProtKB=H8WGV2	Protein CBR-ITR-1, isoform a	ISS	1849282	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00049	Parkinson disease	P01211	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	IDA	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00383	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00051	TCA cycle	P01266	Pyruvate Dehydrogenase	CHLTR|EnsemblGenome=CT_245|UniProtKB=O84247	Pyruvate dehydrogenase E1 component subunit alpha	ISS	15604966	gi	PTHR11516:SF53	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ORYSJ|EnsemblGenome=OS02G0148100|UniProtKB=Q6Z437	Mitogen-activated protein kinase 3	ISS	10514528	PubMed	PTHR24055:SF216	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01152	RasGAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00006	Apoptosis signaling pathway	P00269	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	HUMAN|HGNC=2212|UniProtKB=P12110	Collagen alpha-2(VI) chain	IC	10778855	PubMed	PTHR44172:SF1	COLLAGEN ALPHA-2 VI  CHAIN
P00047	PDGF signaling pathway	P01167	Ets	BOVIN|Ensembl=ENSBTAG00000002341|UniProtKB=A5PJG9	ETS1 protein	ISS	15298723	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00018	EGF receptor signaling pathway	P00544	c-Cbl	RAT|RGD=620535|UniProtKB=Q8K4S7	E3 ubiquitin-protein ligase CBL-B	ISS	95303504	PubMed	PTHR23007:SF3	E3 UBIQUITIN-PROTEIN LIGASE CBL-B
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00036	Interleukin signaling pathway	P00965	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MOUSE|MGI=MGI=88399|UniProtKB=P32211	Muscarinic acetylcholine receptor M4	TAS	91373358	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MOUSE|MGI=MGI=109248|UniProtKB=Q920H4	Muscarinic acetylcholine receptor M5	TAS	10069496	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00036	Interleukin signaling pathway	P00996	STAT	MONDO|Ensembl=ENSMODG00000014816|UniProtKB=F7CHH2	Signal transducer and activator of transcription	ISS	95236292	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MOUSE|MGI=MGI=108460|UniProtKB=Q61091	Frizzled-8	TAS	8717036	PubMed	PTHR11309:SF90	FRIZZLED-8
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000012820|UniProtKB=F1MDL3	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	BOVIN|Ensembl=ENSBTAG00000010191|UniProtKB=Q08E52	Serine/threonine-protein kinase PAK 1	ISS	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	DANRE|ZFIN=ZDB-GENE-040718-93|UniProtKB=Q6DGZ5	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00021	FGF signaling pathway	P00644	p38	CAEEL|WormBase=WBGene00004055|UniProtKB=Q17446	Mitogen-activated protein kinase pmk-1	IGI	11703092	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00049	Parkinson disease	P01242	Casein kinase I	MACMU|Ensembl=ENSMMUG00000005012|UniProtKB=F7AM42	Casein kinase I isoform alpha-like protein	ISS	10617630	PubMed	PTHR11909:SF139	CASEIN KINASE I ISOFORM ALPHA-LIKE
P00047	PDGF signaling pathway	P01161	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	15621031	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01465	Ggamma	MOUSE|MGI=MGI=102705|UniProtKB=P63213	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IDA	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00049	Parkinson disease	P01208	Hsp70	HUMAN|HGNC=5241|UniProtKB=P11142	Heat shock cognate 71 kDa protein	IDA	12150907	PubMed	PTHR19375:SF239	HEAT SHOCK COGNATE 71 KDA PROTEIN
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IGI	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P06587	Nicotine pharmacodynamics pathway	P06604	SLC18A2	PANTR|Ensembl=ENSPTRG00000002979|UniProtKB=H2Q2M8	Uncharacterized protein	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	XENTR|Xenbase=XB-GENE-480347|UniProtKB=Q6P640	Actin, alpha cardiac muscle 1	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05917	Opioid proopiomelanocortin pathway	P06010	proopiomelanocortin	RAT|RGD=3366|UniProtKB=P01194	Pro-opiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00057	Wnt signaling pathway	P01472	Histone deacetylase	ARATH|TAIR=AT3G44680|UniProtKB=Q8H0W2	Histone deacetylase 9	IDA	10485845	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000017612|UniProtKB=C7G3N0	Glutamate receptor, metabotropic 6	ISS	11431030	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00047	PDGF signaling pathway	P01162	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	LEIMA|EnsemblGenome=LmjF.04.0960|UniProtKB=Q9U1D3	Putative adenylate kinase	ISS			PTHR23359:SF107	UMP-CMP KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	PANTR|Ensembl=ENSPTRG00000022726|UniProtKB=H2R3V0	Cholinergic receptor, nicotinic, gamma	ISS	95224005	PubMed	PTHR18945:SF60	ACETYLCHOLINE RECEPTOR SUBUNIT GAMMA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01208	Hsp70	HUMAN|HGNC=5233|UniProtKB=P0DMV9	Heat shock 70 kDa protein 1B	IDA	12150907	PubMed	PTHR19375:SF223	HEAT SHOCK 70 KDA PROTEIN 1A-RELATED
P04375	5HT3 type receptor mediated signaling pathway	P04425	K+ channel	BOVIN|Ensembl=ENSBTAG00000018193|UniProtKB=E1BHX8	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	TAKRU|Ensembl=ENSTRUG00000008018|UniProtKB=H2T5N4	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IDA	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02762	Pentose phosphate pathway	P03077	D-Ribulo Kinase	GLOVI|Gene=BAC90063|UniProtKB=Q7NIR0	Phosphoribulokinase	ISS			PTHR10285:SF6	ATP-DEPENDENT KINASE TDA10-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	TAKRU|Ensembl=ENSTRUG00000009259|UniProtKB=H2TF39	Uncharacterized protein	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	IGI	12701063	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	IC	8838325	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00052	TGF-beta signaling pathway	P01284	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01148	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	8051109	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	RCA	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00200	Dsh	MOUSE|MGI=MGI=94941|UniProtKB=P51141	Segment polarity protein dishevelled homolog DVL-1	ISS	11212302	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P00010	B cell activation	P00385	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00011	Blood coagulation	P00420	GP V	MOUSE|MGI=MGI=1096363|UniProtKB=O08742	Platelet glycoprotein V	ISS	6449037	gi	PTHR24373:SF144	PLATELET GLYCOPROTEIN V
P00005	Angiogenesis	P00203	Erk	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00017	DNA replication	P00536	DNA Topisomerase	TAKRU|Ensembl=ENSTRUG00000000575|UniProtKB=H2RMK7	Uncharacterized protein	ISS			PTHR10290:SF13	TOPOISOMERASE  DNA  I, LIKE
P00021	FGF signaling pathway	P00642	MEK1-2	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IGI	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00048	PI3 kinase pathway	P01199	Galpha	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS			PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04398	p53 pathway feedback loops 2	P04651	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00053	T cell activation	P01315	Calcineurin	BOVIN|Ensembl=ENSBTAG00000020133|UniProtKB=A5D7T5	Serine/threonine-protein phosphatase	ISS	12015605	PubMed	PTHR11668:SF186	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT GAMMA ISOFORM
P00011	Blood coagulation	P00429	PN2	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	ISS	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01451	Galpha	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00007	Axon guidance mediated by semaphorins	P00336	Cdk5	MACMU|Ensembl=ENSMMUG00000020451|UniProtKB=F6VZU3	Uncharacterized protein	ISS	10604473,	PubMed	PTHR24056:SF46	CYCLIN-DEPENDENT-LIKE KINASE 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00017	DNA replication	P00527	Histones	STRPU|EnsemblGenome=SPU_021279|UniProtKB=W4YZJ8	Uncharacterized protein	ISS	12413958	PubMed	PTHR11426:SF20	HISTONE H3-LIKE CENTROMERIC PROTEIN A
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	FUSNN|EnsemblGenome=FN1340|UniProtKB=Q8RDZ8	Glutamate--tRNA ligase	ISS			PTHR43311:SF2	GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00029	Huntington disease	P00780	Microtubule	STRPU|EnsemblGenome=SPU_000062|UniProtKB=W4X9L8	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CAEEL|WormBase=WBGene00006374|UniProtKB=P91409	Putative syntaxin-4	IC			PTHR19957:SF142	SYNTAXIN-4-RELATED
P00060	Ubiquitin proteasome pathway	P01492	E1	CANLF|Ensembl=ENSCAFG00000014944|UniProtKB=E2RGH5	Uncharacterized protein	ISS			PTHR10953:SF155	UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 1
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	CANLF|Ensembl=ENSCAFG00000005035|UniProtKB=F1PGW4	Serine/threonine-protein kinase receptor	ISS	9395284	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P00047	PDGF signaling pathway	P01159	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	IC	14744463	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P05918	p38 MAPK pathway	P06024	eIF4E	CHICK|Ensembl=ENSGALG00000028828|UniProtKB=R4GGL4	Uncharacterized protein	ISS			PTHR11960:SF14	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	RCA	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000014576|UniProtKB=H2QLZ9	Uncharacterized protein	ISS	11431030	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	MACMU|Ensembl=ENSMMUG00000020819|UniProtKB=F7HSM1	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05730	Endogenous cannabinoid signaling	P05746	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00036	Interleukin signaling pathway	P00990	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04393	Ras Pathway	P04570	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00219	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00018	EGF receptor signaling pathway	P00539	14-3-3	MOUSE|MGI=MGI=108109|UniProtKB=P61982	14-3-3 protein gamma	ISS	10407019	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P04392	P53 pathway feedback loops 1	P04539	p53	MACMU|Ensembl=ENSMMUG00000008639|UniProtKB=P56424	Cellular tumor antigen p53	TAS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00021	FGF signaling pathway	P00623	FGF	CANLF|Ensembl=ENSCAFG00000015361|UniProtKB=E2REX2	Fibroblast growth factor	ISS	11801566	PubMed	PTHR11486:SF25	FIBROBLAST GROWTH FACTOR 6
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	MOUSE|MGI=MGI=1921575|UniProtKB=Q6IRU5	Clathrin light chain B	ISS	9388255	PubMed	PTHR10639:SF2	CLATHRIN LIGHT CHAIN B
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00009	Axon guidance mediated by netrin	P00364	cdc42	BRAFL|Gene=BRAFLDRAFT_122664|UniProtKB=C3ZIB9	Putative uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P04393	Ras Pathway	P04557	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	MOUSE|MGI=MGI=98848|UniProtKB=P12656	Thyrotropin subunit beta	ISS	3017658	PubMed	PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00059	p53 pathway	P01486	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00029	Huntington disease	P00778	NMDA receptor	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00004	Alzheimer disease-presenilin pathway	P00126	Fe65	MONDO|Ensembl=ENSMODG00000020566|UniProtKB=F7APL6	Uncharacterized protein (Fragment)	ISS			PTHR14058:SF11	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 2
P04398	p53 pathway feedback loops 2	P04661	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	ISS	9620264	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	BOVIN|Gene=SLC18A2|UniProtKB=Q27963	Synaptic vesicular amine transporter	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02785	Valine biosynthesis	P03215	Branched chain amino acid aminotransferase	ARATH|TAIR=AT3G19710|UniProtKB=Q9LE06	Methionine aminotransferase BCAT4	ISS			PTHR42825:SF4	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 6-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	CHICK|Ensembl=ENSGALG00000014033|UniProtKB=E1BTS2	Uncharacterized protein	ISS	99084794	PubMed	PTHR24070:SF186	GTPASE KRAS
P05913	Enkephalin release	P05972	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	GIAIC|EnsemblGenome=GL50803_40817|UniProtKB=A8BV70	Actin related protein	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00048	PI3 kinase pathway	P01199	Galpha	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00034	Integrin signalling pathway	P00936	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IPI	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	BOVIN|Ensembl=ENSBTAG00000009269|UniProtKB=F1MCM2	Uncharacterized protein	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00021	FGF signaling pathway	P00636	FGFR1-4	MOUSE|MGI=MGI=95525|UniProtKB=Q03142	Fibroblast growth factor receptor 4	IEP	92146274	PubMed	PTHR24416:SF343	FIBROBLAST GROWTH FACTOR RECEPTOR 4
P00053	T cell activation	P01312	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	ENTHI|EnsemblGenome=EHI_181250|UniProtKB=C4M5Z7	Rho family GTPase	ISS	12932731	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00034	Integrin signalling pathway	P00938	Cdc42	DAPPU|EnsemblGenome=DAPPUDRAFT_306746|UniProtKB=E9GYE9	Putative uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00036	Interleukin signaling pathway	P00965	ERK	PANTR|Ensembl=ENSPTRG00000020224|UniProtKB=H2Q9G3	Mitogen-activated protein kinase 6	ISS	8444355	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P02783	Tryptophan biosynthesis	P03208	Tryptophan synthase B	SYNY3|EnsemblGenome=BAA10837|UniProtKB=Q59992	Tryptophan synthase beta chain	ISS			PTHR42882:SF3	TRYPTOPHAN SYNTHASE BETA CHAIN 1, CHLOROPLASTIC-RELATED
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IPI	8787761	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04578	Rho	PANTR|Ensembl=ENSPTRG00000001112|UniProtKB=H2PZP2	Ras homolog gene family, member C	ISS	14871999	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00059	p53 pathway	P04633	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00013	Cell cycle	P00489	CdkC	PANTR|Ensembl=ENSPTRG00000020433|UniProtKB=H2R9R9	Uncharacterized protein	RCA			PTHR10177:SF70	G1/S-SPECIFIC CYCLIN-E2
P00030	Hypoxia response via HIF activation	P00819	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04558	p38	TAKRU|Ensembl=ENSTRUG00000008723|UniProtKB=H2TB66	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF331	SUBFAMILY NOT NAMED
P00012	Cadherin signaling pathway	P00470	F-actin	CHICK|Ensembl=ENSGALG00000009844|UniProtKB=P68034	Actin, alpha cardiac muscle 1	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00059	p53 pathway	G04694	p110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CAEBR|Gene=CBG05858|UniProtKB=A8X1H0	Protein CBR-EGL-19 (Fragment)	ISS	11956331	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IDA	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P02774	Salvage pyrimidine deoxyribonucleotides	P03148	Thymidine phosphorylase	METJA|EnsemblGenome=MJ_0667|UniProtKB=Q58081	AMP phosphorylase	ISS	8688087	PubMed	PTHR10515:SF0	THYMIDINE PHOSPHORYLASE
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	IXOSC|EnsemblGenome=ISCW003614|UniProtKB=B7PHY7	Cdc42 protein, putative	ISS	4757952	gi	PTHR24072:SF192	CDC42 HOMOLOG
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00260	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00586	Gq	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00641	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00005	Angiogenesis	P00206	Wnt	HUMAN|HGNC=12784|UniProtKB=P41221	Protein Wnt-5a	ISS	11266476	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P02781	Threonine biosynthesis	P03191	Homoserine kinase	ARATH|TAIR=AT2G17265|UniProtKB=Q8L7R2	Homoserine kinase	ISS			PTHR20861:SF1	HOMOSERINE KINASE
P00005	Angiogenesis	P00207	Crk	BOVIN|Ensembl=ENSBTAG00000005665|UniProtKB=E1BQ32	Uncharacterized protein	ISS	8649368	PubMed	PTHR19969:SF8	ADAPTER MOLECULE CRK
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00036	Interleukin signaling pathway	P00981	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	RAT|RGD=621060|UniProtKB=O88777	Presenilin-2	IDA	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IGI	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01005	NR2D	RAT|RGD=2740|UniProtKB=Q62645	Glutamate receptor ionotropic, NMDA 2D	ISS	14698601	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00057	Wnt signaling pathway	P01465	Ggamma	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00006	Apoptosis signaling pathway	P00269	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	21186066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PLAF7|EnsemblGenome=PF14_0124|UniProtKB=Q8ILW9	Actin-2	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00559	MEK1-2	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	PANTR|Ensembl=ENSPTRG00000011307|UniProtKB=H2QGV8	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF245	RAS-RELATED PROTEIN R-RAS
P00049	Parkinson disease	P01238	14-3-3	MOUSE|MGI=MGI=894689|UniProtKB=P62259	14-3-3 protein epsilon	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	IDA	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00010	B cell activation	P00392	I kappa B	CANLF|Ensembl=ENSCAFG00000030599|UniProtKB=Q5WR08	NFKBIL1	ISS	10811867	PubMed	PTHR15263:SF1	NF-KAPPA-B INHIBITOR-LIKE PROTEIN 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02913	Thymidylate synthase	DANRE|ZFIN=ZDB-GENE-040426-59|UniProtKB=Q6P045	Tyms protein	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P02763	Peptidoglycan biosynthesis	P03086	N-acetylglucosamine-1-phosphate uridyltransferase	DEIRA|EnsemblGenome=DR_0808|UniProtKB=Q9RW61	Bifunctional protein GlmU	ISS			PTHR43584:SF3	BIFUNCTIONAL PROTEIN GLMU
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IDA			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00627	ERK1-2	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00634	MEKK1-5	BOVIN|Ensembl=ENSBTAG00000009065|UniProtKB=F1MXH6	Uncharacterized protein	ISS	11730323	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000023202|UniProtKB=F7EU36	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00748	Gbeta5L	MOUSE|MGI=MGI=101848|UniProtKB=P62881	Guanine nucleotide-binding protein subunit beta-5	IDA	9754712	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	EMENI|EnsemblGenome=CADANIAG00002670|UniProtKB=Q5BH99	G-protein beta subunit [Source:UniProtKB/TrEMBLAcc:O74214]	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P06211	BMP/activin signaling pathway-drosophila	P06241	TGFbetaR I	DROME|FlyBase=FBgn0011300|UniProtKB=A1Z7L8	Receptor protein serine/threonine kinase	RCA	http://www.reactome.org/	Website	PTHR23255:SF71	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P02787	Vitamin B6 metabolism	P03242	Threonine synthase	AQUAE|EnsemblGenome=aq_608|UniProtKB=O66864	Threonine synthase	ISS	9537320	PubMed	PTHR10314:SF96	SUBFAMILY NOT NAMED
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	IC	2372396	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00020	FAS signaling pathway	P00615	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	IDA	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	MOUSE|MGI=MGI=109284|UniProtKB=Q61144	Presenilin-2	TAS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00047	PDGF signaling pathway	P01161	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00474	Wnt	DROME|FlyBase=FBgn0010194|UniProtKB=P28466	Protein Wnt-5	IDA	11266476	PubMed	PTHR12027:SF77	PROTEIN WNT-5
P04398	p53 pathway feedback loops 2	P04665	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01241	TH	BOVIN|Gene=TH|UniProtKB=P17289	Tyrosine 3-monooxygenase	TAS	12814656	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00048	PI3 kinase pathway	P01177	P110ACT	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00402	Jnk	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01472	Histone deacetylase	HUMAN|HGNC=4852|UniProtKB=Q13547	Histone deacetylase 1	IDA	12665570	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P00047	PDGF signaling pathway	P01154	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	BOVIN|Ensembl=ENSBTAG00000005714|UniProtKB=Q3ZC07	Actin, alpha cardiac muscle 1	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04398	p53 pathway feedback loops 2	P04665	AKT	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	ISS	12655147	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00632	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	DROME|FlyBase=FBgn0025743|UniProtKB=Q9VXE5	Serine/threonine-protein kinase PAK mbt	ISS			PTHR24361:SF345	SERINE/THREONINE-PROTEIN KINASE PAK 4
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	ORYSJ|EnsemblGenome=OS03G0661300|UniProtKB=Q76FS2	Tubulin beta-8 chain	ISS	12932731	PubMed	PTHR11588:SF246	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00577	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	129387	gi	PTHR10048:SF14	PI-3 KINASE
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04395	Vasopressin synthesis	P04597	Signal Peptide	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00023	General transcription regulation	P00658	TBP-associated factors	BOVIN|Gene=TAF7|UniProtKB=Q2HJG8	Transcription initiation factor TFIID subunit 7	ISS			PTHR12228:SF6	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 7
P00005	Angiogenesis	P00223	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00641	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00833	RGS	PANTR|Ensembl=ENSPTRG00000001791|UniProtKB=H2R8B2	Uncharacterized protein	ISS	12193720	PubMed	PTHR10845:SF32	REGULATOR OF G-PROTEIN SIGNALING 13
P00005	Angiogenesis	P00206	Wnt	BRAFL|Gene=BRAFLDRAFT_118160|UniProtKB=C3Z2P0	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF77	PROTEIN WNT-5
P00057	Wnt signaling pathway	P01443	Phospholipase C	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00012	Cadherin signaling pathway	P00470	F-actin	CIOIN|Ensembl=ENSCING00000001377|UniProtKB=F6SDC9	Uncharacterized protein	ISS			PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00005	Angiogenesis	P00219	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00056	VEGF signaling pathway	P01417	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000005917|UniProtKB=F6QM53	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MACMU|Ensembl=ENSMMUG00000020084|UniProtKB=F7GP56	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF427	MYOSIN-3
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	MOUSE|MGI=MGI=2447811|UniProtKB=A6ZI46	Fructose-bisphosphate aldolase	ISS	74094688	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P05915	Opioid proenkephalin pathway	P05985	Mu or Delta receptor	RAT|RGD=3233|UniProtKB=P33533	Delta-type opioid receptor	RCA	11259487	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00057	Wnt signaling pathway	P01451	Galpha	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IDA	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00010	B cell activation	P00391	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02723	Adenine and hypoxanthine salvage pathway	P02811	Adenosine deaminase	BOVIN|Gene=ADA|UniProtKB=P56658	Adenosine deaminase	ISS			PTHR11409:SF43	ADENOSINE DEAMINASE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MOUSE|MGI=MGI=1309999|UniProtKB=Q922R0	cAMP-dependent protein kinase catalytic subunit PRKX	IC	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MOUSE|MGI=MGI=1276116|UniProtKB=B2RWS6	Histone acetyltransferase p300	ISS	10823891	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00006	Apoptosis signaling pathway	P00302	ATF	MONDO|Ensembl=ENSMODG00000015970|UniProtKB=F7FD05	Uncharacterized protein	ISS	14604761	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00029	Huntington disease	P00796	Kainate receptor	RAT|RGD=71027|UniProtKB=P42264	Glutamate receptor ionotropic, kainate 3	IDA	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00053	T cell activation	P01332	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	IDA	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00036	Interleukin signaling pathway	P00965	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IC	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00018	EGF receptor signaling pathway	P00546	GAP	HUMAN|HGNC=9871|UniProtKB=P20936	Ras GTPase-activating protein 1	IGI	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00018	EGF receptor signaling pathway	P00558	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00020	FAS signaling pathway	P00615	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	TAS	7600581	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=1351340|UniProtKB=Q9QYS2	Metabotropic glutamate receptor 3	IDA	20012997	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P04398	p53 pathway feedback loops 2	P04665	AKT	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05915	Opioid proenkephalin pathway	P05991	Enkephalin	XENTR|Xenbase=XB-GENE-942760|UniProtKB=F6Y5F6	Uncharacterized protein	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-478663|UniProtKB=F7EG64	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00037	Ionotropic glutamate receptor pathway	P00998	stargazin	PANTR|Ensembl=ENSPTRG00000009559|UniProtKB=H2RDX3	Voltage-dependent calcium channel gamma subunit	ISS	11140673	PubMed	PTHR12107:SF4	VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-5 SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	IXOSC|EnsemblGenome=ISCW009711|UniProtKB=B7Q3T6	THO complex subunit, putative	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MONDO|Ensembl=ENSMODG00000017165|UniProtKB=F6QDH4	Uncharacterized protein	ISS	15155845	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	PANTR|Ensembl=ENSPTRG00000010931|UniProtKB=H2R650	Uncharacterized protein	ISS	15226293	PubMed	PTHR13715:SF15	RYANODINE RECEPTOR 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06812	L-type Ca2+	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	RCA	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MACMU|Ensembl=ENSMMUG00000004475|UniProtKB=F7GIP9	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF29	72 KDA TYPE IV COLLAGENASE
P05730	Endogenous cannabinoid signaling	P05746	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00034	Integrin signalling pathway	P00906	Rap1	MONDO|Ensembl=ENSMODG00000015869|UniProtKB=F7F073	Uncharacterized protein	ISS			PTHR24073:SF269	DNAJ HOMOLOG SUBFAMILY C MEMBER 27
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	DANRE|ZFIN=ZDB-GENE-030616-563|UniProtKB=Q7SXL3	TATA-box-binding protein	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	RAT|RGD=621060|UniProtKB=O88777	Presenilin-2	TAS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00056	VEGF signaling pathway	P01408	Akt/PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	METAC|EnsemblGenome=MA_1919|UniProtKB=Q8TPJ2	Adenylosuccinate synthetase 1	IEP	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	RCA	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00034	Integrin signalling pathway	P00925	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IDA	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-030131-9966|UniProtKB=Q6TH03	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00047	PDGF signaling pathway	P01150	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00006	Apoptosis signaling pathway	P00322	Cytochrome C	SCHPO|PomBase=SPCC191.07|UniProtKB=P00046	Cytochrome c	ISS			PTHR11961:SF12	CYTOCHROME C
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CIOIN|Ensembl=ENSCING00000000848|UniProtKB=F6SCP4	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04398	p53 pathway feedback loops 2	G04709	MDM-2	RAT|RGD=1305332|UniProtKB=A0A0G2JVC1	Protein Mdm2	ISS	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00036	Interleukin signaling pathway	P00975	RasGAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04393	Ras Pathway	P04564	MAPKAP	HUMAN|HGNC=6888|UniProtKB=Q16644	MAP kinase-activated protein kinase 3	IDA	11335727	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	MOUSE|MGI=MGI=1351343|UniProtKB=Q5NCH9	Metabotropic glutamate receptor 6	ISS	12488551	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DROME|FlyBase=FBgn0000047|UniProtKB=P83967	Actin, indirect flight muscle	IDA	14684598	PubMed	PTHR11937:SF368	ACTIN, INDIRECT FLIGHT MUSCLE
P00053	T cell activation	P01304	Csk	BOVIN|Ensembl=ENSBTAG00000021424|UniProtKB=Q0VBZ0	Tyrosine-protein kinase CSK	ISS	11078745	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00034	Integrin signalling pathway	P00912	Arp2/3	TAKRU|Ensembl=ENSTRUG00000014419|UniProtKB=H2UIU6	Uncharacterized protein	ISS	10940259	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	RCA	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00048	PI3 kinase pathway	P01202	p85	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	RAT|RGD=1305515|UniProtKB=F1M0G0	Protein Rgs17	ISS	8756726	PubMed	PTHR10845:SF196	REGULATOR OF G-PROTEIN SIGNALING 17
P00005	Angiogenesis	P00223	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=18539|UniProtKB=P61266	Syntaxin-1B	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P04396	Vitamin D metabolism and pathway	P04605	P450 reductase	PANTR|Ensembl=ENSPTRG00000019313|UniProtKB=H2QUS7	NADPH--cytochrome P450 reductase	ISS	2513880	PubMed	PTHR19384:SF17	NADPH--CYTOCHROME P450 REDUCTASE
P00057	Wnt signaling pathway	P01438	PP2A	PANTR|Ensembl=ENSPTRG00000017238|UniProtKB=H2QRH7	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MACMU|Ensembl=ENSMMUG00000010266|UniProtKB=F6PV18	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00047	PDGF signaling pathway	P01154	Ras	CHICK|Ensembl=ENSGALG00000014033|UniProtKB=E1BTS2	Uncharacterized protein	ISS	99084794	PubMed	PTHR24070:SF186	GTPASE KRAS
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	EMENI|EnsemblGenome=CADANIAG00006296|UniProtKB=Q5ASG1	Putative synaptobrevin homologue SNC1/2 (Eurofung)	ISS			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	CANLF|Ensembl=ENSCAFG00000004658|UniProtKB=Q8MJW8	C-C chemokine receptor type 4	ISS	11698495	PubMed	PTHR10489:SF608	C-C CHEMOKINE RECEPTOR TYPE 4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	BOVIN|Ensembl=ENSBTAG00000013657|UniProtKB=Q8SPU7	Neuronal acetylcholine receptor subunit alpha-5	IC	12388584	PubMed	PTHR18945:SF76	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5
P05913	Enkephalin release	P05972	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04570	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	METJA|EnsemblGenome=MJ_1174|UniProtKB=Q58574	CTP synthase	ISS			PTHR11550:SF0	CTP SYNTHASE
P00004	Alzheimer disease-presenilin pathway	P00163	Erb-B4 C-terminal fragment	ORNAN|Ensembl=ENSOANG00000007021|UniProtKB=F7GAV2	Receptor protein-tyrosine kinase	ISS	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	TAKRU|Ensembl=ENSTRUG00000007253|UniProtKB=H2SZQ1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P02747	Histidine biosynthesis	P02985	Histidinol dehydrogenase	ARATH|TAIR=AT5G63890|UniProtKB=Q9C5U8	Histidinol dehydrogenase, chloroplastic	ISS			PTHR21256:SF2	HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00036	Interleukin signaling pathway	P00997	Shc	MOUSE|MGI=MGI=98296|UniProtKB=P98083	SHC-transforming protein 1	IGI	8264585	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MACMU|Ensembl=ENSMMUG00000023588|UniProtKB=F7HFQ4	Uncharacterized protein	ISS	6753462	gi	PTHR10489:SF664	C-C CHEMOKINE RECEPTOR TYPE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	EMENI|EnsemblGenome=CADANIAG00002113|UniProtKB=O93937	Protein pyrABCN	ISS			PTHR11405:SF5	CAD PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_56698|UniProtKB=C3XYC3	Putative uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	DROME|FlyBase=FBgn0004611|UniProtKB=P25455	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II	ISS	10934033	PubMed	PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P05915	Opioid proenkephalin pathway	P05994	G-protein	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00048	PI3 kinase pathway	P01202	p85	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01179	PKB	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IGI	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00830	Lipoxygenase	MOUSE|MGI=MGI=107505|UniProtKB=P30355	Arachidonate 5-lipoxygenase-activating protein	IDA	11937571	PubMed	PTHR10250:SF2	ARACHIDONATE 5-LIPOXYGENASE-ACTIVATING PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00139	E-cadherin transmembrane fragment	MOUSE|MGI=MGI=88356|UniProtKB=P10287	Cadherin-3	IDA	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Ensembl=ENSBTAG00000007635|UniProtKB=F1MLS3	Phosphoinositide phospholipase C	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	MOUSE|MGI=MGI=2151136|UniProtKB=Q9JI18	Low-density lipoprotein receptor-related protein 1B	IDA	11907044	PubMed	PTHR44025:SF7	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	RAT|RGD=1309504|UniProtKB=D3ZRN3	Protein Actbl2	ISS	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00036	Interleukin signaling pathway	P00973	PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00134	Nectin 1alpha transmembrane fragment	CANLF|Ensembl=ENSCAFG00000012012|UniProtKB=F1PCB6	Uncharacterized protein	ISS	12376527	PubMed	PTHR23277:SF69	NECTIN-1
P00053	T cell activation	P01306	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00048	PI3 kinase pathway	P01190	PDK1 ACT	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00060	Ubiquitin proteasome pathway	P01491	E2	DANRE|ZFIN=ZDB-GENE-040426-2919|UniProtKB=Q6PEH5	Ubiquitin-conjugating enzyme E2 variant 2	ISS			PTHR43915:SF3	UBIQUITIN-CONJUGATING ENZYME E2 VARIANT 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DROME|FlyBase=FBgn0000044|UniProtKB=P53501	Actin-57B	IC	10974003	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	CANLF|Gene=PSEN1|UniProtKB=Q6RH31	Presenilin-1	TAS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00034	Integrin signalling pathway	P00938	Cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00053	T cell activation	P01312	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	CANLF|Ensembl=ENSCAFG00000007780|UniProtKB=F1PZH9	Uncharacterized protein	ISS			PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00018	EGF receptor signaling pathway	P00554	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	10982827	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01435	SWI/SNF	PANTR|Ensembl=ENSPTRG00000005081|UniProtKB=H2Q680	Uncharacterized protein	ISS	11532957	PubMed	PTHR12802:SF38	SWI/SNF COMPLEX SUBUNIT SMARCC2
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IGI	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00047	PDGF signaling pathway	P01154	Ras	MONDO|Gene=KRAS|UniProtKB=Q07983	GTPase KRas	ISS	9869449	PubMed	PTHR24070:SF186	GTPASE KRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00045	Notch signaling pathway	P01116	Delta	MOUSE|MGI=MGI=94900|UniProtKB=Q09163	Protein delta homolog 1	ISS			PTHR24052:SF11	PROTEIN DELTA HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00046	Oxidative stress response	P01125	Stat1	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	IC	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	MOUSE|MGI=MGI=1931052|UniProtKB=A6ZI47	Fructose-bisphosphate aldolase	ISS	84261525	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00059	p53 pathway	P04609	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	TAS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00047	PDGF signaling pathway	P01153	GSK3	CANLF|Ensembl=ENSCAFG00000004882|UniProtKB=F1PAE3	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00018	EGF receptor signaling pathway	P00547	PP2A	DANRE|ZFIN=ZDB-GENE-040426-2487|UniProtKB=Q803G3	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P02734	Chorismate biosynthesis	P02873	Shikimate dehydrogenase	LEPIN|EnsemblGenome=LA_0638|UniProtKB=Q8F8C0	Shikimate dehydrogenase (NADP(+))	ISS			PTHR21089:SF1	BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE/SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00030	Hypoxia response via HIF activation	P00819	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	HUMAN|HGNC=10616|UniProtKB=P55774	C-C motif chemokine 18	TAS	12401480	PubMed	PTHR12015:SF94	C-C MOTIF CHEMOKINE 18
P00020	FAS signaling pathway	P00602	DAXX	MOUSE|MGI=MGI=1197015|UniProtKB=O35613	Death domain-associated protein 6	IGI	9215629	PubMed	PTHR12766:SF7	DEATH DOMAIN-ASSOCIATED PROTEIN 6
P00012	Cadherin signaling pathway	P00475	Frizzled	MACMU|Ensembl=ENSMMUG00000007486|UniProtKB=F6QL95	Frizzled-3	ISS	8717036	PubMed	PTHR11309:SF22	FRIZZLED-3
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	MACMU|Ensembl=ENSMMUG00000019999|UniProtKB=F7FNE2	Uncharacterized protein	ISS	92370677	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00018	EGF receptor signaling pathway	P00543	ERK1-2	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	HUMAN|HGNC=1952|UniProtKB=P20309	Muscarinic acetylcholine receptor M3	IDA	12915051	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P06211	BMP/activin signaling pathway-drosophila	P06241	TGFbetaR I	DROME|Gene=Dmel_CG1891|UniProtKB=A0A0B4K7J3	Receptor protein serine/threonine kinase	RCA	8134837	PubMed	PTHR23255:SF72	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00243	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01227	20S proteasome	TRYB2|Gene=Tb927.7.4420|UniProtKB=Q57X58	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF13	PROTEASOME SUBUNIT ALPHA TYPE-4
P00034	Integrin signalling pathway	P00943	Talin	BOVIN|Ensembl=ENSBTAG00000025868|UniProtKB=F1MDH3	Uncharacterized protein	ISS	14702644	PubMed	PTHR19981:SF7	MESODERM DEVELOPMENT CANDIDATE 1-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02757	O-antigen biosynthesis	P03046	dTDP-glucose pyrophosphorylase	GLOVI|Gene=BAC89724|UniProtKB=Q7NJP9	Glucose-1-phosphate thymidylyltransferase	ISS			PTHR43532:SF1	GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000016097|UniProtKB=E1B9S9	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P01480	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	PHYIT|EnsemblGenome=PITG_06376|UniProtKB=D0N4Q3	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta, putative	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00034	Integrin signalling pathway	P00919	Arf6	DANRE|ZFIN=ZDB-GENE-030131-8007|UniProtKB=Q6P2U5	Uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00054	Toll receptor signaling pathway	P01346	TLR	PANTR|Ensembl=ENSPTRG00000028318|UniProtKB=H2R4T7	Uncharacterized protein	ISS			PTHR44312:SF1	TOLL-LIKE RECEPTOR 7
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	HUMAN|HGNC=465|UniProtKB=Q16671	Anti-Muellerian hormone type-2 receptor	TAS	9759503	PubMed	PTHR23255:SF49	ANTI-MUELLERIAN HORMONE TYPE-2 RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BRAFL|Gene=BRAFLDRAFT_220697|UniProtKB=C3ZSF0	Putative uncharacterized protein	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00048	PI3 kinase pathway	P01192	p110	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	TAS	15210700	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	IDA	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00021	FGF signaling pathway	P00647	SHP2	CHICK|Ensembl=ENSGALG00000004821|UniProtKB=Q90687	Tyrosine-protein phosphatase non-receptor type 11	ISS	95163101	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04557	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MOUSE|MGI=MGI=1351338|UniProtKB=P97772	Metabotropic glutamate receptor 1	IDA	7476890	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00787	MAPKK4	MACMU|Ensembl=ENSMMUG00000019842|UniProtKB=F7FU91	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	MOUSE|MGI=MGI=105062|UniProtKB=Q8K592	Anti-Muellerian hormone type-2 receptor	TAS	9759503	PubMed	PTHR23255:SF49	ANTI-MUELLERIAN HORMONE TYPE-2 RECEPTOR
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00046	Oxidative stress response	P01129	JNK1/2	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	TAS	11007936	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014262|UniProtKB=F7BYS8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05972	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	RAT|RGD=1309318|UniProtKB=D4A3N4	Adenylate cyclase 1 (Predicted)	ISS	2491850	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P00021	FGF signaling pathway	P00638	PLCgamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00019	Endothelin signaling pathway	P00586	Gq	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	ISS	2574500	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	RAT|RGD=2342|UniProtKB=P08482	Muscarinic acetylcholine receptor M1	IDA	11166329	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00034	Integrin signalling pathway	P00923	Arf1	CHLRE|EnsemblGenome=CHLREDRAFT_186126|UniProtKB=A8IL29	Small ARF-related GTPase	IPI	12932731	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	MOUSE|MGI=MGI=94941|UniProtKB=P51141	Segment polarity protein dishevelled homolog DVL-1	TAS	12549854	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P00029	Huntington disease	P00807	Actin	CHICK|Gene=ACTA2|UniProtKB=P08023	Actin, aortic smooth muscle	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	11035810	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	CAEBR|Gene=CBG_05938|UniProtKB=H8WGV2	Protein CBR-ITR-1, isoform a	ISS	12880387	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00001	Adrenaline and noradrenaline biosynthesis	P00068	amine translocator	HUMAN|HGNC=31399|UniProtKB=Q9H1V8	Sodium-dependent neutral amino acid transporter SLC6A17	IC	12719981	PubMed	PTHR11616:SF102	SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER SLC6A17
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00034	Integrin signalling pathway	P00925	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IDA	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00011	Blood coagulation	P00420	GP V	HUMAN|HGNC=4443|UniProtKB=P40197	Platelet glycoprotein V	ISS	4758460	gi	PTHR24373:SF144	PLATELET GLYCOPROTEIN V
P00019	Endothelin signaling pathway	P00566	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04552	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P02774	Salvage pyrimidine deoxyribonucleotides	P03145	Uracil phosphorylase	ECOLI|EcoGene=EG10219|UniProtKB=P07650	Thymidine phosphorylase	ISS	11206551	PubMed	PTHR10515:SF0	THYMIDINE PHOSPHORYLASE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	TAKRU|Ensembl=ENSTRUG00000009259|UniProtKB=H2TF39	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00008	Axon guidance mediated by Slit/Robo	P00355	Rho	DAPPU|EnsemblGenome=DAPPUDRAFT_301996|UniProtKB=E9HL06	Putative uncharacterized protein	ISS	7798239	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P04393	Ras Pathway	P04543	MEKK1/4	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00021	FGF signaling pathway	P00633	Ras	CHICK|Ensembl=ENSGALG00000014033|UniProtKB=E1BTS2	Uncharacterized protein	ISS	3023884	PubMed	PTHR24070:SF186	GTPASE KRAS
P00021	FGF signaling pathway	P00629	PP2A	BOVIN|Ensembl=ENSBTAG00000005533|UniProtKB=F1N1S8	Uncharacterized protein	ISS	96161994	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	LEIMA|EnsemblGenome=LmjF.04.1230|UniProtKB=Q9U1E8	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	HUMAN|HGNC=4596|UniProtKB=Q14833	Metabotropic glutamate receptor 4	IC	12351712	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	CANLF|Ensembl=ENSCAFG00000010092|UniProtKB=P01321	Insulin	ISS			PTHR11454:SF9	INSULIN-RELATED
P00012	Cadherin signaling pathway	P00466	EGFR	MACMU|Ensembl=ENSMMUG00000001674|UniProtKB=F7G3H1	Receptor protein-tyrosine kinase	ISS	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00006	Apoptosis signaling pathway	P00291	MEKK1	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	ISS	8940199	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06710	Junc	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	RCA	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P05913	Enkephalin release	P05977	G-Protein (s)	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00095	Nicastrin	HUMAN|HGNC=17091|UniProtKB=Q92542	Nicastrin	IDA	16096062	PubMed	PTHR21092:SF0	NICASTRIN
P06664	Gonadotropin-releasing hormone receptor pathway	P06832	c-Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	RCA	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04397	p53 pathway by glucose deprivation	G04706	TSC2	TAKRU|Ensembl=ENSTRUG00000008958|UniProtKB=H2TCY4	Uncharacterized protein	ISS	12150915	PubMed	PTHR10063:SF0	TUBERIN
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00046	Oxidative stress response	P01124	Myc	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	IC			PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	RCA	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1170702	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	METAC|EnsemblGenome=MA_3407|UniProtKB=Q8TKJ8	Cytidine/deoxycytidylate deaminase family protein	ISS			PTHR44192:SF2	SUBFAMILY NOT NAMED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DROME|FlyBase=FBgn0003093|UniProtKB=P13678	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00052	TGF-beta signaling pathway	P01292	RSmads	CHICK|Ensembl=ENSGALG00000006309|UniProtKB=Q56I99	Mothers against decapentaplegic homolog 5	ISS	9395284	PubMed	PTHR13703:SF36	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ORYSJ|EnsemblGenome=OS02G0148100|UniProtKB=Q6Z437	Mitogen-activated protein kinase 3	ISS	12787066	PubMed	PTHR24055:SF216	SUBFAMILY NOT NAMED
P00010	B cell activation	P00375	Calmodulin	ARATH|TAIR=AT3G43810|UniProtKB=P59220	Calmodulin-7	ISS	3885394	PubMed	PTHR23050:SF250	CALMODULIN-7
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MOUSE|MGI=MGI=2139279|UniProtKB=P58406	Histamine H3 receptor	IDA			PTHR44152:SF4	HISTAMINE H3 RECEPTOR
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	12707323	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04393	Ras Pathway	P04558	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IDA	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00018	EGF receptor signaling pathway	P00562	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00029	Huntington disease	P00775	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	15470041	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00068	amine translocator	MOUSE|MGI=MGI=1921588|UniProtKB=Q9D687	Sodium-dependent neutral amino acid transporter B(0)AT1	IC	12719981	PubMed	PTHR11616:SF125	SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER B 0 AT1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000001384|UniProtKB=F7GL73	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00010	B cell activation	P00381	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00580	ET-RA/B	MOUSE|MGI=MGI=105923|UniProtKB=Q61614	Endothelin-1 receptor	ISS	12538737	PubMed	PTHR24243:SF31	ENDOTHELIN-1 RECEPTOR
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	BOVIN|Ensembl=ENSBTAG00000009269|UniProtKB=F1MCM2	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00006	Apoptosis signaling pathway	P00311	GCKR	MOUSE|MGI=MGI=1346882|UniProtKB=P70218	Mitogen-activated protein kinase kinase kinase kinase 1	ISS			PTHR24361:SF88	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 1
P00053	T cell activation	P01324	rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	DROME|FlyBase=FBgn0014011|UniProtKB=P48554	Ras-related protein Rac2	ISS			PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05913	Enkephalin release	P05974	G-Protein (i)	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00005	Angiogenesis	P00203	Erk	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00020	FAS signaling pathway	P00598	Pro-Caspase10	HUMAN|HGNC=1500|UniProtKB=Q92851	Caspase-10	IGI	11717445	PubMed	PTHR10454:SF26	CASPASE-10
P00057	Wnt signaling pathway	P01471	alpha-catenin	BOVIN|Gene=CTNNA1|UniProtKB=Q3MHM6	Catenin alpha-1	ISS	9362521	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	TAS	7937853	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00018	EGF receptor signaling pathway	P00552	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00018	EGF receptor signaling pathway	P00539	14-3-3	HUMAN|HGNC=12849|UniProtKB=P31946	14-3-3 protein beta/alpha	IGI	12618428	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	3755548	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	ORNAN|Ensembl=ENSOANG00000004058|UniProtKB=F6TYP9	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P06587	Nicotine pharmacodynamics pathway	P06613	CHRNB2	HUMAN|HGNC=1962|UniProtKB=P17787	Neuronal acetylcholine receptor subunit beta-2	TAS	22213672	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	XENTR|Xenbase=XB-GENE-923233|UniProtKB=Q6AZK9	Nucleoside diphosphate kinase	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P00060	Ubiquitin proteasome pathway	P01491	E2	PANTR|Ensembl=ENSPTRG00000015998|UniProtKB=G2HEI6	Ubiquitin-conjugating enzyme E2-25 kDa	ISS			PTHR44020:SF2	UBIQUITIN-CONJUGATING ENZYME E2 K
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	METJA|EnsemblGenome=MJ_1346|UniProtKB=Q60182	Glutamine synthetase	ISS			PTHR43785:SF1	TYPE-1 GLUTAMINE SYNTHETASE 2
P02781	Threonine biosynthesis	P03190	Threonine synthase	THEMA|EnsemblGenome=TM_0546|UniProtKB=Q9WZ16	Threonine synthase	ISS			PTHR10314:SF5	THREONINE SYNTHASE 1, CHLOROPLASTIC
P00060	Ubiquitin proteasome pathway	P01491	E2	HUMAN|HGNC=12479|UniProtKB=Q969T4	Ubiquitin-conjugating enzyme E2 E3	ISS			PTHR24068:SF63	UBIQUITIN-CONJUGATING ENZYME E2 E3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01412	HSP27	MOUSE|MGI=MGI=96240|UniProtKB=P14602	Heat shock protein beta-1	RCA			PTHR11527:SF114	HEAT SHOCK PROTEIN BETA-1
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	CAEEL|WormBase=WBGene00004769|UniProtKB=P52166	Presenilin sel-12	TAS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00018	EGF receptor signaling pathway	P00547	PP2A	HUMAN|HGNC=9309|UniProtKB=Q15172	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform	ISS	10092233	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00034	Integrin signalling pathway	P00942	Fyn	MOUSE|MGI=MGI=95602|UniProtKB=P39688	Tyrosine-protein kinase Fyn	IPI	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00054	Toll receptor signaling pathway	P01358	ERK1	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00006	Apoptosis signaling pathway	P00321	HSP70	PLAF7|EnsemblGenome=PF08_0054|UniProtKB=Q8IB24	Heat shock protein 70	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MACMU|Ensembl=ENSMMUG00000030028|UniProtKB=F7H0X2	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IC	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Gene=PLCD4|UniProtKB=P21671	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	7822322	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00046	Oxidative stress response	P01134	cPLA2	BOVIN|Ensembl=ENSBTAG00000013298|UniProtKB=A4IFJ5	Cytosolic phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P05730	Endogenous cannabinoid signaling	P05746	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02786	Vitamin B6 biosynthesis	P03225	1-Deoxyxylulose-5-phosphate synthase	ARATH|TAIR=AT4G15560|UniProtKB=Q38854	1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic	ISS			PTHR43322:SF5	1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE 1-RELATED
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04556	Raf	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00053	T cell activation	P01335	jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	HUMAN|HGNC=2561|UniProtKB=P61073	C-X-C chemokine receptor type 4	IDA	11943720	PubMed	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	ISS	15860573	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00010	B cell activation	P00384	p38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	RAT|RGD=621534|UniProtKB=P43144	Neuronal acetylcholine receptor subunit alpha-9	IC			PTHR18945:SF489	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-9
P00036	Interleukin signaling pathway	P00996	STAT	TAKRU|Ensembl=ENSTRUG00000015348|UniProtKB=H2UQK9	Signal transducer and activator of transcription	ISS	15452141	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00046	Oxidative stress response	P01129	JNK1/2	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05730	Endogenous cannabinoid signaling	P05746	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IC	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00045	Notch signaling pathway	P01113	Pen-2	CHICK|Gene=PSEN2|UniProtKB=Q90X07	Presenilin-2	ISS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	ARATH|TAIR=AT2G29900|UniProtKB=Q9SIK7	Presenilin-like protein At2g29900	TAS	12834808	PubMed	PTHR10202:SF22	SUBFAMILY NOT NAMED
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	RCA	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00046	Oxidative stress response	P01125	Stat1	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	12191995	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P06664	Gonadotropin-releasing hormone receptor pathway	P06839	PLD	MOUSE|MGI=MGI=106604|UniProtKB=O70362	Phosphatidylinositol-glycan-specific phospholipase D	RCA			PTHR23221:SF7	PHOSPHATIDYLINOSITOL-GLYCAN-SPECIFIC PHOSPHOLIPASE D
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MONDO|Ensembl=ENSMODG00000015246|UniProtKB=F6UJF5	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	TAS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00049	Parkinson disease	P01242	Casein kinase I	ORYSJ|EnsemblGenome=OS01G0772600|UniProtKB=Q8S1J0	Os01g0772600 protein	IDA	10617630	PubMed	PTHR11909:SF153	SUBFAMILY NOT NAMED
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	MONDO|Ensembl=ENSMODG00000007421|UniProtKB=F6XBV3	Uncharacterized protein	ISS	8930069	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00029	Huntington disease	P00790	beta-Tubulin	STRPU|EnsemblGenome=SPU_007424|UniProtKB=W4XVG8	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF155	TUBULIN BETA-2 CHAIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000015241|UniProtKB=Q5IS72	D(3) dopamine receptor	ISS	7651368	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00053	T cell activation	P01330	IKK	PANTR|Ensembl=ENSPTRG00000020202|UniProtKB=H2QW34	Uncharacterized protein	ISS	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P04393	Ras Pathway	P04570	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MONDO|Ensembl=ENSMODG00000005136|UniProtKB=F7EQH3	Uncharacterized protein (Fragment)	ISS	9230079	PubMed	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CHICK|Ensembl=ENSGALG00000026802|UniProtKB=G1K338	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	HUMAN|HGNC=7881|UniProtKB=P46531	Neurogenic locus notch homolog protein 1	IDA	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01161	Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02756	N-acetylglucosamine metabolism	P03041	Glucosamine-6-phosphate deaminase	GIAIC|EnsemblGenome=GL50803_8245|UniProtKB=E2RU05	Glucosamine-6-phosphate isomerase	ISS			PTHR11280:SF5	GLUCOSAMINE-6-PHOSPHATE ISOMERASE
P00006	Apoptosis signaling pathway	P00302	ATF	XENTR|Xenbase=XB-GENE-945015|UniProtKB=F6QA46	Uncharacterized protein	ISS	11752053	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00016	Cytoskeletal regulation by Rho GTPase	P00521	Profilin	DICDI|dictyBase=DDB_G0286187|UniProtKB=P26200	Profilin-2	ISS			PTHR11604:SF3	PROFILIN-2
P00021	FGF signaling pathway	P00648	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	CANLF|Ensembl=ENSCAFG00000007935|UniProtKB=E2R6Q9	Uncharacterized protein	ISS	11055438	PubMed	PTHR10117:SF56	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	TAS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P06664	Gonadotropin-releasing hormone receptor pathway	P06850	PKCs(3)	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	RCA	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	BOVIN|Ensembl=ENSBTAG00000034854|UniProtKB=F1N246	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IGI	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00005	Angiogenesis	P00203	Erk	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01215	Syntaxin	PANTR|Ensembl=ENSPTRG00000000416|UniProtKB=H2PYG1	Syntaxin 12	ISS	14570579	PubMed	PTHR19957:SF88	SYNTAXIN-12
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05914	Nicotine degradation	P05981	INMT	PANTR|Ensembl=ENSPTRG00000019045|UniProtKB=H2QUD4	Uncharacterized protein	ISS			PTHR10867:SF6	INDOLETHYLAMINE N-METHYLTRANSFERASE-RELATED
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8701|UniProtKB=Q9Y5H0	Protocadherin gamma-A3	IDA	8120095	PubMed	PTHR24028:SF232	PROTOCADHERIN GAMMA-A3
P00053	T cell activation	P01332	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	IDA	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00546	GAP	MACMU|Ensembl=ENSMMUG00000004639|UniProtKB=F6TDB7	Disabled homolog 2-interacting protein isoform 2	ISS	14735459	gi	PTHR10194:SF26	DISABLED HOMOLOG 2-INTERACTING PROTEIN
P04393	Ras Pathway	P04558	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	IDA	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	HUMAN|HGNC=4571|UniProtKB=P42261	Glutamate receptor 1	ISS	10331083	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00010	B cell activation	P00369	MEKK	RAT|RGD=620967|UniProtKB=F1M9D0	Protein Map3k2	ISS	8649450	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00010	B cell activation	P00371	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00054	Toll receptor signaling pathway	P01375	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00047	PDGF signaling pathway	P01154	Ras	CHICK|Ensembl=ENSGALG00000000613|UniProtKB=Q5F3R8	Uncharacterized protein	ISS			PTHR24073:SF335	RAS-RELATED PROTEIN RAB-11B
P00048	PI3 kinase pathway	P01188	Gbetagamma	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	IC	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CHICK|Ensembl=ENSGALG00000002098|UniProtKB=F1P0L4	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P05913	Enkephalin release	P05974	G-Protein (i)	CRYNJ|EnsemblGenome=CND03830|UniProtKB=Q5KI86	Uncharacterized protein	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00048	PI3 kinase pathway	P01177	P110ACT	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IDA	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TRYB2|Gene=Tb09.211.0620|UniProtKB=Q38E94	Actin A	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	ORYSJ|EnsemblGenome=OS05G0106600|UniProtKB=Q65XH8	Os05g0106600 protein	IC	14684598	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P04393	Ras Pathway	P04567	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IDA	10799299	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01076	CAT	PANTR|Ensembl=ENSPTRG00000002489|UniProtKB=H2RAF8	Uncharacterized protein	ISS	97225904	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P00006	Apoptosis signaling pathway	P00260	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00562	p38	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	IGI	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT4G01370|UniProtKB=Q39024	Mitogen-activated protein kinase 4	ISS	10527417	PubMed	PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P02761	Pantothenate biosynthesis	P03069	2-Dehydropantoate reductase	LEPIN|EnsemblGenome=LA_3613|UniProtKB=Q8F083	2-dehydropantoate 2-reductase	ISS			PTHR43765:SF1	2-DEHYDROPANTOATE 2-REDUCTASE
P00057	Wnt signaling pathway	P01465	Ggamma	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00021	FGF signaling pathway	P00627	ERK1-2	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PHYPA|Gene=PHYPADRAFT_223215|UniProtKB=Q6TYR8	Beta-tubulin 6	ISS	12932731	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MOUSE|MGI=MGI=1309999|UniProtKB=Q922R0	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04393	Ras Pathway	P04570	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00025	Hedgehog signaling pathway	P00693	Ubiquitin ligase	XENTR|Ensembl=ENSXETG00000031995|UniProtKB=F6ZM01	Uncharacterized protein	ISS			PTHR11254:SF402	E3 UBIQUITIN-PROTEIN LIGASE UBR5
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P06959	CCKR signaling map	P07155	CDC42-GTP	HUMAN|HGNC=1736|UniProtKB=P60953	Cell division control protein 42 homolog	RCA	15331357	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05730	Endogenous cannabinoid signaling	P05751	Galpha	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000008806|UniProtKB=H2QCB5	Adenosine receptor A2	ISS			PTHR24246:SF18	ADENOSINE RECEPTOR A2B
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-050417-59|UniProtKB=Q15KE4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00036	Interleukin signaling pathway	P00987	SRF	BOVIN|Ensembl=ENSBTAG00000012777|UniProtKB=E1BJP4	Uncharacterized protein	ISS	15326221	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	CAEEL|WormBase=WBGene00002173|UniProtKB=Q9Y0A1	Inositol 1,4,5-trisphosphate receptor itr-1	ISS	12880387	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05731	GABA-B receptor II signaling	P05760	AC	CANLF|Gene=ADCY6|UniProtKB=P30804	Adenylate cyclase type 6	RCA	2491850	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01161	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00010	B cell activation	P00394	BLNK	MACMU|Ensembl=ENSMMUG00000008687|UniProtKB=F7EYN2	Uncharacterized protein	ISS	11274146	PubMed	PTHR14098:SF3	B-CELL LINKER PROTEIN
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00005	Angiogenesis	P00189	Fzd	MACMU|Ensembl=ENSMMUG00000007486|UniProtKB=F6QL95	Frizzled-3	ISS	12549854	PubMed	PTHR11309:SF22	FRIZZLED-3
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00634	MEKK1-5	RAT|RGD=620966|UniProtKB=Q62925	Mitogen-activated protein kinase kinase kinase 1	IGI	12168099	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02722	Acetate utilization	P02802	Phosphate acetyltransferase	METAC|EnsemblGenome=MA_3607|UniProtKB=Q8TK18	Phosphate acetyltransferase	ISS			PTHR43356:SF3	PHOSPHATE ACETYLTRANSFERASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	MOUSE|MGI=MGI=96433|UniProtKB=Q60751	Insulin-like growth factor 1 receptor	ISS	2877871	PubMed	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	DANRE|ZFIN=ZDB-GENE-040426-2385|UniProtKB=Q6P3K7	Casein kinase I isoform delta-B	ISS	11437445	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04559	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12176041	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CHICK|Ensembl=ENSGALG00000008512|UniProtKB=F1P0S6	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ANOGA|EnsemblGenome=AGAP000651|UniProtKB=P84185	Actin-5C	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	CANLF|Gene=GRIN1|UniProtKB=Q5R1P0	Glutamate receptor ionotropic, NMDA 1	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	BOVIN|Ensembl=ENSBTAG00000008026|UniProtKB=P01175	Oxytocin-neurophysin 1	ISS	192340	OMIM	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00005	Angiogenesis	P00223	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IDA	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	PANTR|Ensembl=ENSPTRG00000018449|UniProtKB=H2QTG5	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00005	Angiogenesis	P00236	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	BOVIN|Gene=KCNJ5|UniProtKB=F1MYR9	G protein-activated inward rectifier potassium channel 4	ISS	2433589	PubMed	PTHR11767:SF52	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 4
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00054	Toll receptor signaling pathway	P01358	ERK1	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	RAT|RGD=2732|UniProtKB=P22756	Glutamate receptor ionotropic, kainate 1	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00048	PI3 kinase pathway	P01192	p110	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04372	5-Hydroxytryptamine degredation	P04401	Monoamine Oxidase	RAT|RGD=3041|UniProtKB=P19643	Amine oxidase [flavin-containing] B	ISS	90344230	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00025	Hedgehog signaling pathway	P00687	Cubitus interruptus repressor	MACMU|Ensembl=ENSMMUG00000013614|UniProtKB=F7GN18	Uncharacterized protein	ISS	15994174	PubMed	PTHR19818:SF5	TRANSCRIPTIONAL ACTIVATOR GLI3
P05913	Enkephalin release	P05972	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P02782	Triacylglycerol metabolism	P03205	Triacylglycerol lipase	RAT|RGD=3010|UniProtKB=P15304	Hormone-sensitive lipase	ISS			PTHR23025:SF3	HORMONE-SENSITIVE LIPASE
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	8836152	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00020	FAS signaling pathway	P00615	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00046	Oxidative stress response	P01129	JNK1/2	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04393	Ras Pathway	P04558	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00007	Axon guidance mediated by semaphorins	P00340	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P02728	Arginine biosynthesis	P02841	argininosuccinate lyase	SCHPO|PomBase=SPBC1539.03c|UniProtKB=P50514	Probable argininosuccinate lyase	ISS			PTHR43814:SF1	ARGININOSUCCINATE LYASE
P00047	PDGF signaling pathway	P01159	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00736	CalDAG-GEF	HUMAN|HGNC=9879|UniProtKB=Q7LDG7	RAS guanyl-releasing protein 2	IDA	10835426	PubMed	PTHR23113:SF16	RAS GUANYL-RELEASING PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CIOIN|Ensembl=ENSCING00000000407|UniProtKB=Q9U6V0	Protein Wnt	TAS	11266476	PubMed	PTHR12027:SF77	PROTEIN WNT-5
P00047	PDGF signaling pathway	P01168	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05994	G-protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	DROME|FlyBase=FBgn0087012|UniProtKB=Q8IPN2	5-hydroxytryptamine (Serotonin) receptor 2A, isoform B	ISS	11859080	PubMed	PTHR24247:SF125	5-HYDROXYTRYPTAMINE  SEROTONIN  RECEPTOR 2A, ISOFORM B
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	88241036	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00045	Notch signaling pathway	G01541	E(spl)-C genes	HUMAN|HGNC=16005|UniProtKB=Q9Y543	Transcription factor HES-2	IC			PTHR10985:SF15	TRANSCRIPTION FACTOR HES-2
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01227	20S proteasome	MACMU|Ensembl=ENSMMUG00000019919|UniProtKB=F7GNS6	Proteasome subunit beta type	ISS	12859888	PubMed	PTHR11599:SF59	PROTEASOME SUBUNIT BETA TYPE-1
P00011	Blood coagulation	P00429	PN2	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	ISS	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00052	TGF-beta signaling pathway	P01275	P38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	TAS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02743	Formyltetrahydroformate biosynthesis	P02952	Methylene tetrahydrofolate dehydrogenase	PSEAE|EnsemblGenome=PA1796|UniProtKB=Q9I2U6	Bifunctional protein FolD	ISS			PTHR10025:SF46	BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, MITOCHONDRIAL
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ARATH|TAIR=AT2G42880|UniProtKB=Q9SJG9	Mitogen-activated protein kinase 20	IDA	12787066	PubMed	PTHR24055:SF158	MITOGEN-ACTIVATED PROTEIN KINASE 20
P00049	Parkinson disease	P01239	Cul-1	ORNAN|Ensembl=ENSOANG00000000278|UniProtKB=F6X2V7	Uncharacterized protein	ISS	12628165	PubMed	PTHR11932:SF81	CULLIN-1
P00052	TGF-beta signaling pathway	P01275	P38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P06959	CCKR signaling map	P07117	BCL2L1	HUMAN|HGNC=992|UniProtKB=Q07817	Bcl-2-like protein 1	RCA	15474972	PubMed	PTHR11256:SF12	BCL-2-LIKE PROTEIN 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MACMU|Ensembl=ENSMMUG00000017683|UniProtKB=F6UA63	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT4G01370|UniProtKB=Q39024	Mitogen-activated protein kinase 4	ISS	10851062	PubMed	PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P00047	PDGF signaling pathway	P01168	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01300	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01143	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10557357	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	HUMAN|HGNC=11364|UniProtKB=P40763	Signal transducer and activator of transcription 3	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00019	Endothelin signaling pathway	P00589	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IGI	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01080	AChE	CANLF|Ensembl=ENSCAFG00000014054|UniProtKB=E2RP98	Carboxylic ester hydrolase	ISS	86008285	PubMed	PTHR11559:SF356	ACETYLCHOLINESTERASE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04556	Raf	TAKRU|Ensembl=ENSTRUG00000011625|UniProtKB=H2TXG3	Uncharacterized protein	ISS	3043188	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	ANOGA|EnsemblGenome=AGAP005912|UniProtKB=Q7Q6D3	AGAP005912-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00005	Angiogenesis	P00234	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	4504111	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04395	Vasopressin synthesis	P04590	Vasopressin	HUMAN|HGNC=8528|UniProtKB=P01178	Oxytocin-neurophysin 1	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00048	PI3 kinase pathway	P01188	Gbetagamma	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00254	GTPase	RAT|RGD=621309|UniProtKB=P62747	Rho-related GTP-binding protein RhoB	ISS	11973360	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P06959	CCKR signaling map	P07121	MAP2K2	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	RCA	7611406	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CANLF|Ensembl=ENSCAFG00000010298|UniProtKB=P11616	Adenosine receptor A1	ISS	12515326	PubMed	PTHR24246:SF1	ADENOSINE RECEPTOR A1
P02775	Salvage pyrimidine ribonucleotides	P03156	CDP kinase	DEIRA|EnsemblGenome=DR_0159|UniProtKB=Q9RXZ5	Uridine kinase	ISS			PTHR10285:SF6	ATP-DEPENDENT KINASE TDA10-RELATED
P00006	Apoptosis signaling pathway	P00298	Caspase 9	HUMAN|HGNC=1511|UniProtKB=P55211	Caspase-9	IDA	9390557	PubMed	PTHR10454:SF157	CASPASE-9
P00011	Blood coagulation	P00437	Kallikrein	RAT|RGD=67382|UniProtKB=P14272	Plasma kallikrein	ISS	6981134	gi	PTHR44459:SF2	PLASMA KALLIKREIN
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MOUSE|MGI=MGI=1346089|UniProtKB=O54829	Regulator of G-protein signaling 7	IDA	8756726	PubMed	PTHR10845:SF26	REGULATOR OF G-PROTEIN SIGNALING 7
P00016	Cytoskeletal regulation by Rho GTPase	P00514	MLCK	MACMU|Ensembl=ENSMMUG00000019786|UniProtKB=F7G5G3	Uncharacterized protein	ISS	11157482	PubMed	PTHR45411:SF1	MYOSIN LIGHT CHAIN KINASE 3
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00047	PDGF signaling pathway	P01157	MAPKAPK2	MACMU|Ensembl=ENSMMUG00000023567|UniProtKB=F7HHY8	Uncharacterized protein	ISS	9628873	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	ARATH|TAIR=AT3G06030|UniProtKB=O22042	Mitogen-activated protein kinase kinase kinase 3	ISS			PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P04397	p53 pathway by glucose deprivation	P04641	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00965	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	TAKRU|Ensembl=ENSTRUG00000002245|UniProtKB=H2RYC6	Uncharacterized protein (Fragment)	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00470	F-actin	CANAL|CGD=CAL0064759|UniProtKB=Q5AKX0	Uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	XENTR|Xenbase=XB-GENE-488998|UniProtKB=Q5BL41	Actin-related protein 2	ISS	11889126	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00036	Interleukin signaling pathway	P00990	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	HUMAN|HGNC=4401|UniProtKB=O14775	Guanine nucleotide-binding protein subunit beta-5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	IDA	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	CAEEL|WormBase=WBGene00002189|UniProtKB=P21137	cAMP-dependent protein kinase catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00059	p53 pathway	G01575	GADD45	BOVIN|Ensembl=ENSBTAG00000003033|UniProtKB=Q2KIX1	Growth arrest and DNA damage-inducible protein GADD45 gamma	ISS	10097101	PubMed	PTHR10411:SF4	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 GAMMA
P00019	Endothelin signaling pathway	P00589	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IGI	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05918	p38 MAPK pathway	P06016	HSP27	MOUSE|MGI=MGI=96240|UniProtKB=P14602	Heat shock protein beta-1	ISS			PTHR11527:SF114	HEAT SHOCK PROTEIN BETA-1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00059	p53 pathway	P01486	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=18539|UniProtKB=P61266	Syntaxin-1B	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00053	T cell activation	P01314	nck	BOVIN|Ensembl=ENSBTAG00000018427|UniProtKB=Q1LZB2	NCK adaptor protein 1	ISS	11689432	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	CANLF|Ensembl=ENSCAFG00000002067|UniProtKB=F1PUW7	Uncharacterized protein	ISS	94365697	PubMed	PTHR11958:SF69	EXCITATORY AMINO ACID TRANSPORTER 3
P00053	T cell activation	P01336	Jnk	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00056	VEGF signaling pathway	P01408	Akt/PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	TAS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01448	CBP	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P05913	Enkephalin release	P05972	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00047	PDGF signaling pathway	P01153	GSK3	MOUSE|MGI=MGI=2152453|UniProtKB=Q2NL51	Glycogen synthase kinase-3 alpha	ISS	11995474	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00059	p53 pathway	P04619	HMG1	RAT|RGD=2802|UniProtKB=P63159	High mobility group protein B1	ISS			PTHR13711:SF164	HIGH MOBILITY GROUP PROTEIN B1-RELATED
P02747	Histidine biosynthesis	P02989	Phosphoribosyl AMP cyclohydrolase	DEIRA|EnsemblGenome=DR_0733|UniProtKB=Q9RWD6	Histidine biosynthesis bifunctional protein HisIE	ISS			PTHR42945:SF1	HISTIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN HISIE, CHLOROPLASTIC
P04393	Ras Pathway	P04552	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	PANTR|Ensembl=ENSPTRG00000016210|UniProtKB=H2QPS3	Bone morphogenetic protein 3	ISS	9759503	PubMed	PTHR11848:SF144	BONE MORPHOGENETIC PROTEIN 3
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	DROME|FlyBase=FBgn0011703|UniProtKB=P48591	Ribonucleoside-diphosphate reductase large subunit	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IDA	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P02744	Fructose galactose metabolism	P02965	UDP Glucose 4 epimerase	TRYB2|Gene=Tb11.02.0330|UniProtKB=Q386N7	UDP-galactose 4-epimerase	ISS			PTHR43349:SF11	UDP-ARABINOSE 4-EPIMERASE 1-RELATED
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=12778|UniProtKB=O14904	Protein Wnt-9a	TAS	8717036	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	IC	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00036	Interleukin signaling pathway	P00987	SRF	MOUSE|MGI=MGI=106658|UniProtKB=Q9JM73	Serum response factor	ISS	15170389	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	PANTR|Ensembl=ENSPTRG00000013189|UniProtKB=H2QJV1	Uncharacterized protein	ISS	192340	OMIM	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00021	FGF signaling pathway	P00630	RKIP	RAT|RGD=62017|UniProtKB=P31044	Phosphatidylethanolamine-binding protein 1	IDA	12591138	PubMed	PTHR11362:SF10	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04398	p53 pathway feedback loops 2	P04657	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	CANLF|Ensembl=ENSCAFG00000008293|UniProtKB=E2R9M9	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF22	FRIZZLED-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	PANTR|Ensembl=ENSPTRG00000000416|UniProtKB=H2PYG1	Syntaxin 12	ISS	14570579	PubMed	PTHR19957:SF88	SYNTAXIN-12
P00047	PDGF signaling pathway	P01148	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12162872	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00047	PDGF signaling pathway	P01161	Raf	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00194	Paxillin	RAT|RGD=620173|UniProtKB=Q99PD6	Transforming growth factor beta-1-induced transcript 1 protein	ISS			PTHR24216:SF27	TRANSFORMING GROWTH FACTOR BETA-1-INDUCED TRANSCRIPT 1 PROTEIN
P00049	Parkinson disease	P01211	ERK	ORYSJ|EnsemblGenome=OS02G0148100|UniProtKB=Q6Z437	Mitogen-activated protein kinase 3	IDA	12787066	PubMed	PTHR24055:SF216	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=12776|UniProtKB=O96014	Protein Wnt-11	IDA	11266476	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00059	p53 pathway	G04702	p53	PANTR|Ensembl=ENSPTRG00000008703|UniProtKB=H2QC53	Cellular tumor antigen p53	ISS	11313951	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CAEBR|Gene=CBG02161|UniProtKB=A8WS32	Protein CBG02161	ISS	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00125	Ire-1 C-terminal fragment	ARATH|TAIR=AT2G17520|UniProtKB=Q9C5S2	Serine/threonine-protein kinase/endoribonuclease IRE1a	IDA	10619423	PubMed	PTHR13954:SF6	INOSITOL-REQUIRING ENZYME-1
P00049	Parkinson disease	G01547	DAT	MOUSE|MGI=MGI=94862|UniProtKB=Q61327	Sodium-dependent dopamine transporter	IDA	92107910	PubMed	PTHR11616:SF38	SODIUM-DEPENDENT DOPAMINE TRANSPORTER
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00021	FGF signaling pathway	P00646	RasGAP	ANOGA|EnsemblGenome=AGAP002729|UniProtKB=Q7QCN5	AGAP002729-PA	ISS	21296043	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DROME|FlyBase=FBgn0000042|UniProtKB=P10987	Actin-5C	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00048	PI3 kinase pathway	P01202	p85	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00006	Apoptosis signaling pathway	P00274	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00182	p38MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00547	PP2A	RAT|RGD=3380|UniProtKB=P63331	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	IGI	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00805	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	HUMAN|HGNC=12023|UniProtKB=P56180	Putative tyrosine-protein phosphatase TPTE	ISS			PTHR12305:SF32	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE TPTE2-RELATED
P00053	T cell activation	P01320	PLC-gamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05918	p38 MAPK pathway	P06040	MSK1	HUMAN|HGNC=10434|UniProtKB=O75582	Ribosomal protein S6 kinase alpha-5	RCA	6755374	gi	PTHR24351:SF115	RIBOSOMAL PROTEIN S6 KINASE ALPHA-5
P04393	Ras Pathway	P04555	PDK	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IC	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00029	Huntington disease	P00807	Actin	ORNAN|Ensembl=ENSOANG00000000460|UniProtKB=F7F4W9	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	HUMAN|HGNC=1389|UniProtKB=Q00975	Voltage-dependent N-type calcium channel subunit alpha-1B	TAS	11976940	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00019	Endothelin signaling pathway	P00566	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00006	Apoptosis signaling pathway	P00303	c-Jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	PYRAE|EnsemblGenome=PAE2969|UniProtKB=Q8ZU33	Glutamate--tRNA ligase	ISS			PTHR43097:SF5	GLUTAMATE--TRNA LIGASE, CYTOPLASMIC
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00054	Toll receptor signaling pathway	G01550	Gene trancription	RAT|RGD=2889|UniProtKB=P97636	Interleukin-18	ISS	9702748	PubMed	PTHR45200:SF1	INTERLEUKIN-18
P00016	Cytoskeletal regulation by Rho GTPase	P00513	Op18/stathmin	MOUSE|MGI=MGI=96739|UniProtKB=P54227	Stathmin	ISS			PTHR10104:SF5	STATHMIN
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	ARATH|TAIR=AT5G61210|UniProtKB=Q9S7P9	SNAP25 homologous protein SNAP33	IC			PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00055	Transcription regulation by bZIP transcription factor	P01396	TFIIFbeta	MONDO|Ensembl=ENSMODG00000025484|UniProtKB=F6QZ41	General transcription factor IIF subunit 2	ISS	92020241	PubMed	PTHR10445:SF0	GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2
P00059	p53 pathway	P01485	p53	MOUSE|MGI=MGI=1336991|UniProtKB=Q9JJP2	Tumor protein p73	TAS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00059	p53 pathway	G04702	p53	DANRE|ZFIN=ZDB-GENE-990415-270|UniProtKB=P79734	Cellular tumor antigen p53	TAS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	RAT|RGD=2958|UniProtKB=P63251	G protein-activated inward rectifier potassium channel 1	ISS	2433589	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04452	proopiomelanocortin	MACMU|Ensembl=ENSMMUG00000016463|UniProtKB=F7GBI0	Uncharacterized protein	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00376	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00006	Apoptosis signaling pathway	P00277	Bi1	MACMU|Ensembl=ENSMMUG00000005960|UniProtKB=F7GWD0	Bax inhibitor 1	ISS			PTHR23291:SF34	BAX INHIBITOR 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	XENTR|Xenbase=XB-GENE-976753|UniProtKB=Q0VFR6	Syntaxin 1A (Brain)	ISS	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00053	T cell activation	P01312	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00019	Endothelin signaling pathway	P00568	PKC	DANRE|ZFIN=ZDB-GENE-040426-1354|UniProtKB=Q7T2C5	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00049	Parkinson disease	P01219	SAPK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	NAS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00005	Angiogenesis	P00200	Dsh	RAT|RGD=1309725|UniProtKB=D3ZB71	Protein Dvl2	ISS	11212302	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000006307|UniProtKB=H2SSM1	Uncharacterized protein	IC			PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	CAEBR|Gene=CBG12820|UniProtKB=A8XFP5	Protein CBR-KIN-3	ISS	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00005	Angiogenesis	P00221	JNK1	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04397	p53 pathway by glucose deprivation	P04641	Akt	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	ISS	98382502	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04541	p90RSK	BOVIN|Ensembl=ENSBTAG00000021741|UniProtKB=F1MNR5	Ribosomal protein S6 kinase	ISS	15526037	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00637	MKK4,7	MACMU|Ensembl=ENSMMUG00000019842|UniProtKB=F7FU91	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00059	p53 pathway	G04694	p110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	PANTR|Ensembl=ENSPTRG00000002795|UniProtKB=H2Q2C0	Metalloendopeptidase	ISS	9759503	PubMed	PTHR43978:SF1	TOLLOID-LIKE PROTEIN 2
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ORYSJ|Gene=Os01g0866100|UniProtKB=P0C540	Actin-7	IDA			PTHR11937:SF205	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8972|UniProtKB=O00750	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	HUMAN|HGNC=4037|UniProtKB=P06241	Tyrosine-protein kinase Fyn	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	NAS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=88356|UniProtKB=P10287	Cadherin-3	IDA	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P00060	Ubiquitin proteasome pathway	P01490	E3	DANRE|ZFIN=ZDB-GENE-040426-2744|UniProtKB=F1QEG9	Uncharacterized protein	ISS	11252892	PubMed	PTHR11254:SF293	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	HUMAN|HGNC=7553|UniProtKB=P01106	Myc proto-oncogene protein	IEP	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00057	Wnt signaling pathway	P01437	TCF	MOUSE|MGI=MGI=1202876|UniProtKB=Q9Z1J1	Transcription factor 7-like 1	IDA	11266476	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00034	Integrin signalling pathway	P00907	ERK	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS			PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00049	Parkinson disease	P01211	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00777	CBP	MOUSE|MGI=MGI=1276116|UniProtKB=B2RWS6	Histone acetyltransferase p300	ISS	10823891	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00626	Spry	CANLF|Ensembl=ENSCAFG00000005260|UniProtKB=E2RGU9	Uncharacterized protein	ISS	12225946	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P00018	EGF receptor signaling pathway	P00558	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00021	FGF signaling pathway	P00639	Shc	MOUSE|MGI=MGI=98296|UniProtKB=P98083	SHC-transforming protein 1	IGI	95096035	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	BOVIN|Gene=GRK7|UniProtKB=Q8WMV0	Rhodopsin kinase	RCA			PTHR24355:SF12	RHODOPSIN KINASE
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	HUMAN|HGNC=15576|UniProtKB=Q8WXR4	Myosin-IIIb	ISS			PTHR13140:SF311	MYOSIN-IIIB
P00034	Integrin signalling pathway	P00916	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	91232861	PubMed	PTHR24070:SF385	GTPASE HRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	DROME|FlyBase=FBgn0023179|UniProtKB=Q9VBC7	Amontillado	IDA			PTHR42884:SF13	NEUROENDOCRINE CONVERTASE 2
P05731	GABA-B receptor II signaling	P05755	Gbeta	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00057	Wnt signaling pathway	P01455	Smad4	DROME|FlyBase=FBgn0011648|UniProtKB=P42003	Protein mothers against dpp	IDA	9395284	PubMed	PTHR13703:SF40	PROTEIN MOTHERS AGAINST DPP
P04398	p53 pathway feedback loops 2	P04663	Mdm2	MOUSE|MGI=MGI=96952|UniProtKB=P23804	E3 ubiquitin-protein ligase Mdm2	IGI	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P05918	p38 MAPK pathway	P06023	MEF	ORNAN|Ensembl=ENSOANG00000011076|UniProtKB=F7FK48	Uncharacterized protein	ISS	11274345	PubMed	PTHR11945:SF25	MYOCYTE-SPECIFIC ENHANCER FACTOR 2C
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00543	ERK1-2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00012	Cadherin signaling pathway	P00462	Casein kinase II	MOUSE|MGI=MGI=88547|UniProtKB=O54833	Casein kinase II subunit alpha'	ISS	10617630	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00047	PDGF signaling pathway	P01160	IP3 receptor	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	TAKRU|Ensembl=ENSTRUG00000002223|UniProtKB=H2RY75	Uncharacterized protein (Fragment)	ISS			PTHR18945:SF761	ALPHA8 SUBUNIT OF NICOTINIC ACETYLCHOLINE RECEPTOR
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	10395542	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	HUMAN|HGNC=7567|UniProtKB=P12882	Myosin-1	IEP	89264452	PubMed	PTHR13140:SF484	MYOSIN-1
P00009	Axon guidance mediated by netrin	P00359	NFAT	HUMAN|HGNC=7778|UniProtKB=Q14934	Nuclear factor of activated T-cells, cytoplasmic 4	IDA	9133421	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00059	p53 pathway	P01486	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	YEAST|SGD=S000005854|UniProtKB=P33328	Synaptobrevin homolog 2	ISS	14997396	PubMed	PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00645	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT4G01370|UniProtKB=Q39024	Mitogen-activated protein kinase 4	IDA	10527417	PubMed	PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	BOVIN|Ensembl=ENSBTAG00000004216|UniProtKB=F1MSX4	Uncharacterized protein	ISS	8621389	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00029	Huntington disease	P00810	GAPDH	CANLF|Ensembl=ENSCAFG00000023617|UniProtKB=F1PFN3	Glyceraldehyde-3-phosphate dehydrogenase	ISS	8612237	PubMed	PTHR10836:SF51	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	ISS	2303451	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P04393	Ras Pathway	P04557	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04393	Ras Pathway	P04570	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00916	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00005	Angiogenesis	P00208	MEKK1	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	ISS	12049732	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P05731	GABA-B receptor II signaling	P05752	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DANRE|ZFIN=ZDB-GENE-041001-104|UniProtKB=Q5TZD4	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05731	GABA-B receptor II signaling	P05755	Gbeta	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000003399|UniProtKB=H2Q383	Phosphoinositide-3-kinase, class 2, alpha polypeptide	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00054	Toll receptor signaling pathway	P01361	TBK1	MOUSE|MGI=MGI=1929658|UniProtKB=Q9WUN2	Serine/threonine-protein kinase TBK1	ISS			PTHR22969:SF14	SERINE/THREONINE-PROTEIN KINASE TBK1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05734	Synaptic vesicle trafficking	P05779	Synaptobrevin	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	RCA	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00049	Parkinson disease	P01211	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	IDA	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	SULSO|EnsemblGenome=SSO0093|UniProtKB=P95968	Glutamate--tRNA ligase	ISS			PTHR43097:SF5	GLUTAMATE--TRNA LIGASE, CYTOPLASMIC
P05918	p38 MAPK pathway	P06032	MKK6	BOVIN|Ensembl=ENSBTAG00000001609|UniProtKB=Q5E9X2	Dual specificity mitogen-activated protein kinase kinase 6	ISS	8622669	PubMed	PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P00053	T cell activation	P01316	MHC-antigen	MACMU|Ensembl=ENSMMUG00000022626|UniProtKB=F6Z0N4	HLA class II histocompatibility antigen, DM beta chain	ISS	3112582	PubMed	PTHR19944:SF65	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DM BETA CHAIN
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000013587|UniProtKB=F7AZ16	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF33	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-3
P00056	VEGF signaling pathway	P01417	Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	ISS	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00018	EGF receptor signaling pathway	P00546	GAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	88318957	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	CAEEL|WormBase=WBGene00001679|UniProtKB=P17343	Guanine nucleotide-binding protein subunit beta-1	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	15737619	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00029	Huntington disease	P00779	TBP	ORYSJ|EnsemblGenome=OS12G0580300|UniProtKB=Q2QN41	Os12g0580300 protein	ISS	11988536	PubMed	PTHR10126:SF36	TATA-BOX-BINDING PROTEIN 1-RELATED
P05731	GABA-B receptor II signaling	P05754	Ggamma	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00018	EGF receptor signaling pathway	P00547	PP2A	DANRE|ZFIN=ZDB-GENE-030904-6|UniProtKB=Q7ZUQ2	Ppp2r5e1 protein	ISS	10092233	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00018	EGF receptor signaling pathway	P00558	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IGI	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000000931|UniProtKB=H2PZC4	Protein kinase N2	ISS	125549	gi	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	PANTR|Ensembl=ENSPTRG00000009822|UniProtKB=G2HEY4	Fibronectin 1	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00047	PDGF signaling pathway	P01160	IP3 receptor	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00007	Axon guidance mediated by semaphorins	P00340	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	10802295	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P02748	Isoleucine biosynthesis	P02995	Threonine dehydratase	ANOGA|EnsemblGenome=AGAP003571|UniProtKB=F5HLA9	AGAP003571-PA	ISS			PTHR43419:SF8	THREONINE AMMONIA-LYASE
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	ORNAN|Ensembl=ENSOANG00000004783|UniProtKB=F7FN72	Actin-related protein 2/3 complex subunit 3	ISS	12473693	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	MOUSE|MGI=MGI=106677|UniProtKB=Q8BRU6	Synaptic vesicular amine transporter	ISS	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00056	VEGF signaling pathway	P01410	Caspase9	PANTR|Ensembl=ENSPTRG00000000200|UniProtKB=H2PY35	Caspase	ISS	11440972	PubMed	PTHR10454:SF157	CASPASE-9
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01021	Vglut	RAT|RGD=628870|UniProtKB=Q7TSF2	Vesicular glutamate transporter 3	ISS	12815758	PubMed	PTHR11662:SF207	VESICULAR GLUTAMATE TRANSPORTER 3
P00029	Huntington disease	P00807	Actin	DROME|FlyBase=FBgn0011743|UniProtKB=P45891	Actin-like protein 53D	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01444	Wnt	RAT|RGD=69250|UniProtKB=Q9QXQ7	Protein Wnt-5a	IDA	11266476	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000020224|UniProtKB=H2Q9G3	Mitogen-activated protein kinase 6	ISS	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TRIAD|EnsemblGenome=TriadG56111|UniProtKB=B3RX77	Non-muscle actin 6.2	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00053	T cell activation	P01311	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	RAT|RGD=620577|UniProtKB=Q62636	Ras-related protein Rap-1b	IDA	1904317	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00235	c-Fos	CANLF|Ensembl=ENSCAFG00000017040|UniProtKB=E2QYK5	Uncharacterized protein	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00052	TGF-beta signaling pathway	P01292	RSmads	PANTR|Ensembl=ENSPTRG00000005788|UniProtKB=H2RCQ5	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF41	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 9
P00029	Huntington disease	P00786	ARF	ORNAN|Ensembl=ENSOANG00000012039|UniProtKB=F7DMS9	Uncharacterized protein	ISS			PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00057	Wnt signaling pathway	P01451	Galpha	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05918	p38 MAPK pathway	P06020	p38delta	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IPI	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	PANTR|Ensembl=ENSPTRG00000005066|UniProtKB=H2Q667	Matrix metallopeptidase 19	ISS	12834808	PubMed	PTHR10201:SF166	MATRIX METALLOPROTEINASE-19
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	RAT|RGD=621005|UniProtKB=Q08849	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00048	PI3 kinase pathway	P01177	P110ACT	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00964	p90RSK	MOUSE|MGI=MGI=104558|UniProtKB=P18653	Ribosomal protein S6 kinase alpha-1	IGI	12769834	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	ISS	11554549	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00007	Axon guidance mediated by semaphorins	P00340	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000011757|UniProtKB=Q9XT97	Presenilin-1	TAS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00019	Endothelin signaling pathway	P00591	PLCbeta	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	MACMU|Ensembl=ENSMMUG00000004657|UniProtKB=G7MVY8	Furin	ISS	10956649	PubMed	PTHR42884:SF1	FURIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04392	P53 pathway feedback loops 1	P04539	p53	CANLF|Gene=TP53|UniProtKB=Q29537	Cellular tumor antigen p53	TAS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	RCA	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	ANOGA|EnsemblGenome=AGAP009731|UniProtKB=Q7PM77	Protein Wnt	TAS	8717036	PubMed	PTHR12027:SF98	PROTEIN WNT-RELATED
P00056	VEGF signaling pathway	P01425	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00047	PDGF signaling pathway	P01173	STAT	PANTR|Ensembl=ENSPTRG00000005121|UniProtKB=H2Q6A5	Uncharacterized protein	ISS	8085155	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00057	Wnt signaling pathway	P01456	beta-arrestin	HUMAN|HGNC=711|UniProtKB=P49407	Beta-arrestin-1	IDA	11742073	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00006	Apoptosis signaling pathway	P00269	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01443	Phospholipase C	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IDA	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	HUMAN|HGNC=4588|UniProtKB=O15399	Glutamate receptor ionotropic, NMDA 2D	ISS	14698601	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00018	EGF receptor signaling pathway	P00564	Rac	DANRE|ZFIN=ZDB-GENE-040724-272|UniProtKB=Q5TZD5	Uncharacterized protein	ISS			PTHR24072:SF17	RHO-RELATED GTP-BINDING PROTEIN RHOJ
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	BOVIN|Ensembl=ENSBTAG00000018445|UniProtKB=E1BK87	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	RAT|RGD=1310096|UniProtKB=B2RZ72	Actin-related protein 2/3 complex subunit 4	ISS	5031595	gi	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00199	JNKK1	HUMAN|HGNC=6844|UniProtKB=P45985	Dual specificity mitogen-activated protein kinase kinase 4	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00833	RGS	HUMAN|HGNC=10000|UniProtKB=P49798	Regulator of G-protein signaling 4	ISS	9774420	PubMed	PTHR10845:SF184	REGULATOR OF G-PROTEIN SIGNALING 4
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01444	Wnt	RAT|RGD=69346|UniProtKB=G3V7U3	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00029	Huntington disease	P00778	NMDA receptor	DROME|FlyBase=FBgn0010399|UniProtKB=Q24418	Glutamate [NMDA] receptor subunit 1	IDA	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P05730	Endogenous cannabinoid signaling	P05748	mGluR	MACMU|Ensembl=ENSMMUG00000016428|UniProtKB=F7GU00	Metabotropic glutamate receptor 1 isoform alpha	ISS	7476890	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00019	Endothelin signaling pathway	P00566	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00799	JNK-2	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	IDA	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00057	Wnt signaling pathway	P01444	Wnt	PANTR|Ensembl=ENSPTRG00000009322|UniProtKB=H2REI3	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF84	PROTEIN WNT-9B
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	PANTR|Ensembl=ENSPTRG00000024326|UniProtKB=H2R231	Uncharacterized protein	ISS	8974401	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P05730	Endogenous cannabinoid signaling	P05748	mGluR	HUMAN|HGNC=4593|UniProtKB=Q13255	Metabotropic glutamate receptor 1	ISS	7476890	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00018	EGF receptor signaling pathway	P00557	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DANRE|ZFIN=ZDB-GENE-040426-1178|UniProtKB=Q7SY24	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04384	Gamma-aminobutyric acid synthesis	P04480	GABA aminotransferase	MOUSE|MGI=MGI=2443582|UniProtKB=P61922	4-aminobutyrate aminotransferase, mitochondrial	RCA			PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	PANTR|Ensembl=ENSPTRG00000012660|UniProtKB=H2QJ07	Activating transcription factor 2	ISS	15218628	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	PANTR|Ensembl=ENSPTRG00000011349|UniProtKB=H2QGY3	Uncharacterized protein	ISS			PTHR10024:SF176	SYNAPTOTAGMIN-3
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT1G10210|UniProtKB=Q39021	Mitogen-activated protein kinase 1	ISS	176948	OMIM	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00048	PI3 kinase pathway	P01200	SHIP	RAT|RGD=68396|UniProtKB=Q9WVR3	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	IDA	10610720	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00047	PDGF signaling pathway	P01153	GSK3	MOUSE|MGI=MGI=2152453|UniProtKB=Q2NL51	Glycogen synthase kinase-3 alpha	ISS	2164470	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02788	Xanthine and guanine salvage pathway	P03245	Guanine phosphoribosyl transferase	AQUAE|EnsemblGenome=aq_544|UniProtKB=O66821	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P04393	Ras Pathway	P04572	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	TAKRU|Ensembl=ENSTRUG00000010022|UniProtKB=H2TKL1	Actin-related protein 2/3 complex subunit 4	ISS	9230079	PubMed	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHLRE|EnsemblGenome=CHLREDRAFT_193901|UniProtKB=Q9FXT7	Mitogen-activated protein kinase	TAS			PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P04393	Ras Pathway	P04558	p38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	IDA	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	P01465	Ggamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CHICK|Ensembl=ENSGALG00000015835|UniProtKB=F1NZT2	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=619748|UniProtKB=P55281	Cadherin-17	IDA	8120095	PubMed	PTHR44603:SF2	CADHERIN-17
P00011	Blood coagulation	P00406	Fibrinogen	PANTR|Ensembl=ENSPTRG00000016534|UniProtKB=H2QQB4	Uncharacterized protein	ISS	6575700	PubMed	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00045	Notch signaling pathway	P01120	NIcs	PANTR|Ensembl=ENSPTRG00000010617|UniProtKB=H2QFL8	Notch 3	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05913	Enkephalin release	P05976	Enkephalin	RAT|RGD=68946|UniProtKB=P04094	Proenkephalin-A	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00048	PI3 kinase pathway	P01199	Galpha	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00271	Bax	RAT|RGD=2192|UniProtKB=Q63690	Apoptosis regulator BAX	ISS	14963330	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00034	Integrin signalling pathway	P00913	Csk	BOVIN|Ensembl=ENSBTAG00000021424|UniProtKB=Q0VBZ0	Tyrosine-protein kinase CSK	ISS	7687537	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00018	EGF receptor signaling pathway	P00564	Rac	DROME|FlyBase=FBgn0010333|UniProtKB=P40792	Ras-related protein Rac1	IGI	12932731	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P02743	Formyltetrahydroformate biosynthesis	P02954	Thymidylate synthase	CAEEL|WormBase=WBGene00022455|UniProtKB=Q9N588	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00005	Angiogenesis	P00187	beta catenin	MOUSE|MGI=MGI=88276|UniProtKB=Q02248	Catenin beta-1	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00010	B cell activation	P00373	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IGI	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	HUMAN|HGNC=6697|UniProtKB=O75197	Low-density lipoprotein receptor-related protein 5	IDA	11029006	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	TAS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00004	Alzheimer disease-presenilin pathway	P00114	actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g242065|UniProtKB=A7S0V7	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00029	Huntington disease	P00785	Cytochrome c	NEUCR|EnsemblGenome=EFNCRG00000009557|UniProtKB=P07142	Cytochrome c1, heme protein, mitochondrial	IDA	9027315	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00029	Huntington disease	P00805	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01159	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02738	De novo purine biosynthesis	P02901	Adenosuccinate lyase	BACSU|EnsemblGenome=BSU06440|UniProtKB=P12047	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CAEEL|WormBase=WBGene00003774|UniProtKB=G5EGQ9	NMDA class glutamate Receptor	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00048	PI3 kinase pathway	P01181	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	TAS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00972	MNK1/2	MOUSE|MGI=MGI=894316|UniProtKB=O08605	MAP kinase-interacting serine/threonine-protein kinase 1	IC	97299868	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000008536|UniProtKB=F6WBZ5	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P04398	p53 pathway feedback loops 2	P04662	cyclin G	MONDO|Ensembl=ENSMODG00000007651|UniProtKB=F7FZG0	Uncharacterized protein	ISS	7957050	PubMed	PTHR10177:SF59	CYCLIN-G1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	HUMAN|HGNC=18856|UniProtKB=Q96BA8	Cyclic AMP-responsive element-binding protein 3-like protein 1	ISS	608972	OMIM	PTHR22952:SF24	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00050	Plasminogen activating cascade	P01254	pro-MMP-13	MACMU|Ensembl=ENSMMUG00000004253|UniProtKB=F6YQ28	Uncharacterized protein	ISS	98180967	PubMed	PTHR10201:SF165	COLLAGENASE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ORYSJ|EnsemblGenome=OS10G0510000|UniProtKB=A3C6D7	Actin-2	ISS	14684598	PubMed	PTHR11937:SF252	SUBFAMILY NOT NAMED
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04543	MEKK1/4	BOVIN|Ensembl=ENSBTAG00000013790|UniProtKB=E1B847	Uncharacterized protein	ISS	8940199	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00203	Erk	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00018	EGF receptor signaling pathway	P00558	SOS	CHICK|Ensembl=ENSGALG00000013224|UniProtKB=F1NMA4	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00059	p53 pathway	P04633	P110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	88107662	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P02738	De novo purine biosynthesis	P02899	GMP synthase	STRCO|EnsemblGenome=CAB82024|UniProtKB=Q9L0H2	GMP synthase [glutamine-hydrolyzing]	ISS			PTHR11922:SF2	GMP SYNTHASE  GLUTAMINE-HYDROLYZING
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=101848|UniProtKB=P62881	Guanine nucleotide-binding protein subunit beta-5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00053	T cell activation	P01332	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	IDA	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	NEUCR|EnsemblGenome=EFNCRG00000004240|UniProtKB=Q01386	cAMP-dependent protein kinase regulatory subunit	ISS	91298951	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00005	Angiogenesis	P00219	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	11591316	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00005	Angiogenesis	P00243	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00053	T cell activation	P01307	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000010521|UniProtKB=F7DQK7	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	BOVIN|Ensembl=ENSBTAG00000009065|UniProtKB=F1MXH6	Uncharacterized protein	ISS	12566458	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000005727|UniProtKB=F6TQT6	Uncharacterized protein	ISS	11554554	PubMed	PTHR24356:SF246	SERINE/THREONINE-PROTEIN KINASE N1
P00036	Interleukin signaling pathway	P00981	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IDA	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00053	T cell activation	P01299	TCR Beta	BOVIN|Ensembl=ENSBTAG00000048016|UniProtKB=G3N2B5	Uncharacterized protein	IDA			PTHR23268:SF6	SUBFAMILY NOT NAMED
P02738	De novo purine biosynthesis	P02909	GDP reductase	TRYB2|Gene=Tb11.02.5720|UniProtKB=Q384N4	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000024633|UniProtKB=F1MBU9	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P04393	Ras Pathway	P04567	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04393	Ras Pathway	P04556	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IDA	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01135	p38	DROME|FlyBase=FBgn0024846|UniProtKB=O61443	Mitogen-activated protein kinase 14B	TAS	10851062	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	MOUSE|MGI=MGI=88296|UniProtKB=O55017	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	14507926	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00029	Huntington disease	P00810	GAPDH	PHYPA|Gene=PHYPADRAFT_150010|UniProtKB=A9TSX3	Glyceraldehyde-3-phosphate dehydrogenase	IPI			PTHR10836:SF52	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	PANTR|Ensembl=ENSPTRG00000005015|UniProtKB=H2Q624	Anti-Muellerian hormone type-2 receptor	ISS	9759503	PubMed	PTHR23255:SF49	ANTI-MUELLERIAN HORMONE TYPE-2 RECEPTOR
P00059	p53 pathway	G04702	p53	RAT|RGD=3889|UniProtKB=P10361	Cellular tumor antigen p53	TAS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	HUMAN|HGNC=1958|UniProtKB=P43681	Neuronal acetylcholine receptor subunit alpha-4	IC	85270494	PubMed	PTHR18945:SF401	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4
P00057	Wnt signaling pathway	P01452	NFAT	MACMU|Ensembl=ENSMMUG00000022596|UniProtKB=F6Z7T2	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF5	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 1
P00036	Interleukin signaling pathway	P00965	ERK	CHICK|Ensembl=ENSGALG00000004690|UniProtKB=Q5F3W3	Mitogen-activated protein kinase 6	ISS	8444355	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	PANTR|Ensembl=ENSPTRG00000006510|UniProtKB=H2Q8K1	Presenilin	ISS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P02752	Mannose metabolism	P03019	P-Mannose mutase	HUMAN|HGNC=9115|UniProtKB=O15305	Phosphomannomutase 2	TAS	11891694	PubMed	PTHR10466:SF2	PHOSPHOMANNOMUTASE 2
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00006	Apoptosis signaling pathway	P00311	GCKR	CAEBR|Gene=CBG19019|UniProtKB=A8XUK9	Protein CBR-GCK-2	ISS			PTHR24361:SF413	HAPPYHOUR, ISOFORM A
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IGI	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01199	Galpha	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00471	Cadherin	XENTR|Xenbase=XB-GENE-482277|UniProtKB=F6QAX3	Uncharacterized protein	ISS	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	TAS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00019	Endothelin signaling pathway	P00568	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00056	VEGF signaling pathway	P01407	Erk	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00936	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IPI	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MACMU|Ensembl=ENSMMUG00000020084|UniProtKB=F7GP56	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF427	MYOSIN-3
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IPI	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01173	STAT	HUMAN|HGNC=11366|UniProtKB=P42229	Signal transducer and activator of transcription 5A	ISS	96210005	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	MONDO|Ensembl=ENSMODG00000015604|UniProtKB=F6Z5L3	S-adenosylmethionine synthase	ISS			PTHR11964:SF12	S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00057	Wnt signaling pathway	P01428	Frizzled	PANTR|Ensembl=ENSPTRG00000012855|UniProtKB=H2QJA9	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF126	FRIZZLED-5
P02752	Mannose metabolism	P03018	Mannose 1-P guanylyl transferase	ARATH|TAIR=AT1G74910|UniProtKB=Q9C9P3	ADP-glucose pyrophosphorylase family protein	TAS	15222037	gi	PTHR22572:SF104	MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE ALPHA
P00010	B cell activation	P00391	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01150	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04393	Ras Pathway	P04558	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	IDA	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	9395335	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	BOVIN|Ensembl=ENSBTAG00000015910|UniProtKB=P53712	Integrin beta-1	ISS	10706722	PubMed	PTHR10082:SF28	INTEGRIN BETA-1
P00036	Interleukin signaling pathway	P00964	p90RSK	CHICK|Ensembl=ENSGALG00000011473|UniProtKB=F1P1H2	Ribosomal protein S6 kinase	ISS	15526037	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00034	Integrin signalling pathway	P00916	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00010	B cell activation	P00392	I kappa B	MACMU|Ensembl=ENSMMUG00000008842|UniProtKB=Q5TM19	NF-kappa-B inhibitor-like protein 1	ISS	10811867	PubMed	PTHR15263:SF1	NF-KAPPA-B INHIBITOR-LIKE PROTEIN 1
P00036	Interleukin signaling pathway	P00968	Ikk	RAT|RGD=1306661|UniProtKB=G3V926	Conserved helix-loop-helix ubiquitous kinase (Predicted)	ISS	12813046	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	BOVIN|Ensembl=ENSBTAG00000018445|UniProtKB=E1BK87	Uncharacterized protein	ISS	11554549	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	8787761	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00912	Arp2/3	MOUSE|MGI=MGI=1928896|UniProtKB=Q9R0Q6	Actin-related protein 2/3 complex subunit 1A	IPI	12963527	gi	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	RCA	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00038	JAK/STAT signaling pathway	P01027	STAT	MONDO|Ensembl=ENSMODG00000011767|UniProtKB=F7CW94	Signal transducer and activator of transcription	ISS	12496413	PubMed	PTHR11801:SF19	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 4
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IDA	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	HUMAN|HGNC=130|UniProtKB=P62736	Actin, aortic smooth muscle	IC	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P04375	5HT3 type receptor mediated signaling pathway	P04421	5HT transporter	PANTR|Ensembl=ENSPTRG00000008958|UniProtKB=H2QCL1	Transporter	ISS	7681602	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P00005	Angiogenesis	P00223	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00034	Integrin signalling pathway	P00909	ASAP1	MACMU|Ensembl=ENSMMUG00000015911|UniProtKB=F7AMJ0	ADP-ribosylation factor GTPase-activating protein 1 isoform b	ISS			PTHR23180:SF35	ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1
P00053	T cell activation	P01307	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00015	Circadian clock system	G01501	cry	MACMU|Ensembl=ENSMMUG00000021808|UniProtKB=F7ENG9	Cryptochrome-1	ISS	14507900	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00035	Interferon-gamma signaling pathway	P00958	PIAS	CANLF|Ensembl=ENSCAFG00000017463|UniProtKB=F1PQ60	Uncharacterized protein	ISS	8682149	PubMed	PTHR10782:SF11	E3 SUMO-PROTEIN LIGASE PIAS1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Ensembl=ENSPTRG00000022245|UniProtKB=H2QZ29	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00006	Apoptosis signaling pathway	P00274	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00029	Huntington disease	P00805	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01167	Ets	DANRE|ZFIN=ZDB-GENE-011010-2|UniProtKB=Q9I9E8	E4tf1-60 transcription factor	ISS	15298723	PubMed	PTHR11849:SF195	GA-BINDING PROTEIN ALPHA CHAIN
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	DROME|FlyBase=FBgn0011286|UniProtKB=Q24498	Ryanodine receptor	ISS	8930069	PubMed	PTHR13715:SF79	RYANODINE RECEPTOR
P04393	Ras Pathway	P04572	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	CHICK|Ensembl=ENSGALG00000006576|UniProtKB=E1BUE5	Uncharacterized protein	ISS	20012997	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00057	Wnt signaling pathway	P01443	Phospholipase C	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00038	JAK/STAT signaling pathway	P01034	Jak	CANLF|Ensembl=ENSCAFG00000002102|UniProtKB=E2RPW6	Tyrosine-protein kinase	ISS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04395	Vasopressin synthesis	P04593	Glycopeptide	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	IC	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00045	Notch signaling pathway	P01109	Aph-1	DROME|FlyBase=FBgn0031458|UniProtKB=Q9VQG2	Gamma-secretase subunit Aph-1	IDA	12110170	PubMed	PTHR12889:SF0	GAMMA-SECRETASE SUBUNIT APH-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00857	IkappaB	MOUSE|MGI=MGI=104741|UniProtKB=Q9Z1E3	NF-kappa-B inhibitor alpha	ISS	14665694	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	ISS	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00839	SHIP	MOUSE|MGI=MGI=1333787|UniProtKB=Q6P549	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	ISS	10610720	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	MOUSE|MGI=MGI=109284|UniProtKB=Q61144	Presenilin-2	IDA	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00057	Wnt signaling pathway	P01435	SWI/SNF	MACMU|Ensembl=ENSMMUG00000012042|UniProtKB=F7GWD7	Uncharacterized protein	ISS	11532957	PubMed	PTHR10799:SF76	TRANSCRIPTION ACTIVATOR BRG1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01407	Erk	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00213	FGF	MOUSE|MGI=MGI=95516|UniProtKB=P15655	Fibroblast growth factor 2	ISS	12917328	PubMed	PTHR11486:SF83	FIBROBLAST GROWTH FACTOR 2
P00011	Blood coagulation	P00458	GP IIIa	XENTR|Xenbase=XB-GENE-1009964|UniProtKB=F6SRR1	Integrin beta (Fragment)	ISS	3487386	PubMed	PTHR10082:SF25	INTEGRIN BETA-3
P00034	Integrin signalling pathway	P00907	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9836512	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	STRPU|EnsemblGenome=SPU_026078|UniProtKB=W4ZD41	Uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF277	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00780	Microtubule	TAKRU|Ensembl=ENSTRUG00000012143|UniProtKB=H2U1C0	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04375	5HT3 type receptor mediated signaling pathway	P04422	5HT3 Rec	HUMAN|HGNC=24003|UniProtKB=Q8WXA8	5-hydroxytryptamine receptor 3C	IC	7509203	PubMed	PTHR18945:SF764	5-HYDROXYTRYPTAMINE RECEPTOR 3C
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	TAS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00012	Cadherin signaling pathway	P00475	Frizzled	RAT|RGD=628817|UniProtKB=Q8K4C8	Frizzled homolog 9 (Drosophila)	ISS	8717036	PubMed	PTHR11309:SF79	FRIZZLED-9
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	RAT|RGD=61863|UniProtKB=P19493	Glutamate receptor 4	ISS	12497607	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P05913	Enkephalin release	P05972	PKA	MOUSE|MGI=MGI=1309999|UniProtKB=Q922R0	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	9166716	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P05918	p38 MAPK pathway	P06025	SRF	HUMAN|HGNC=11291|UniProtKB=P11831	Serum response factor	RCA	8660892	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00057	Wnt signaling pathway	P01455	Smad4	MOUSE|MGI=MGI=1328787|UniProtKB=P97454	Mothers against decapentaplegic homolog 5	IDA	12736218	PubMed	PTHR13703:SF36	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000010392|UniProtKB=F7ASR8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00029	Huntington disease	P00780	Microtubule	RAT|RGD=628595|UniProtKB=Q4QRB4	Tubulin beta-3 chain	IDA	9454836	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00643	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01197	Caspase-9	PANTR|Ensembl=ENSPTRG00000000200|UniProtKB=H2PY35	Caspase	ISS	9390557	PubMed	PTHR10454:SF157	CASPASE-9
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	HUMAN|HGNC=4404|UniProtKB=P59768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IDA	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00018	EGF receptor signaling pathway	P00559	MEK1-2	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00006	Apoptosis signaling pathway	P00321	HSP70	BOVIN|Ensembl=ENSBTAG00000039035|UniProtKB=F1MWU9	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF168	HEAT SHOCK 70 KDA PROTEIN 6-RELATED
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00056	VEGF signaling pathway	P01415	MAPKAPK2/3	BOVIN|Ensembl=ENSBTAG00000016532|UniProtKB=Q3SYZ2	MAP kinase-activated protein kinase 3	ISS	11335727	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	SCHMA|EnsemblGenome=Smp_183710|UniProtKB=G4VLW1	Putative actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05913	Enkephalin release	P05974	G-Protein (i)	DROME|FlyBase=FBgn0001122|UniProtKB=P16378	G protein alpha o subunit	IC	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00046	Oxidative stress response	P01129	JNK1/2	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000009900|UniProtKB=F1NHL1	Serine/threonine-protein kinase	ISS	12393506	PubMed	PTHR22968:SF9	SERINE/THREONINE-PROTEIN KINASE D1
P04398	p53 pathway feedback loops 2	P04649	Myc	HUMAN|HGNC=7553|UniProtKB=P01106	Myc proto-oncogene protein	TAS	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04395	Vasopressin synthesis	P04594	Neurophysin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P02721	ATP synthesis	P02796	F1 gamma	STRCO|EnsemblGenome=CAB94543|UniProtKB=Q9K4D4	ATP synthase gamma chain	ISS	7828915	PubMed	PTHR11693:SF22	ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL
P04372	5-Hydroxytryptamine degredation	P04401	Monoamine Oxidase	XENTR|Xenbase=XB-GENE-5749883|UniProtKB=F6V922	Uncharacterized protein (Fragment)	ISS	90344230	PubMed	PTHR43563:SF2	AMINE OXIDASE  FLAVIN-CONTAINING
P00056	VEGF signaling pathway	P01414	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	RAT|RGD=2026|UniProtKB=P68035	Actin, alpha cardiac muscle 1	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04374	5HT2 type receptor mediated signaling pathway	P04417	5HT transporter	MACMU|Gene=SLC6A4|UniProtKB=Q9MYX0	Sodium-dependent serotonin transporter	ISS	7681602	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P02741	Flavin biosynthesis	P02937	3,4-Dihydroxy-2-butanone-4-phosphate synthase	YEAST|SGD=S000002895|UniProtKB=Q99258	3,4-dihydroxy-2-butanone 4-phosphate synthase	ISS			PTHR21327:SF18	3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE
P00012	Cadherin signaling pathway	P00470	F-actin	DROME|FlyBase=FBgn0000043|UniProtKB=P02572	Actin-42A	ISS	14684598	PubMed	PTHR11937:SF369	ACTIN-42A
P00034	Integrin signalling pathway	P00916	Ras	EMENI|EnsemblGenome=CADANIAG00002552|UniProtKB=Q12526	Ras-like protein	ISS	7997267	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00047	PDGF signaling pathway	P01162	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00046	Oxidative stress response	P01132	c-jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	11840290	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00049	Parkinson disease	P01235	Fyn kinase	XENTR|Xenbase=XB-GENE-6053489|UniProtKB=F6S8L5	Tyrosine-protein kinase	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05913	Enkephalin release	P05978	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12701063	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00010	B cell activation	P00379	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00049	Parkinson disease	P01242	Casein kinase I	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g161273|UniProtKB=A7RPJ6	Predicted protein	ISS	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00048	PI3 kinase pathway	P01199	Galpha	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02744	Fructose galactose metabolism	P02963	Ketohexokinase	MACMU|Ensembl=ENSMMUG00000016047|UniProtKB=F7GPR3	Uncharacterized protein	ISS	9799106	PubMed	PTHR43085:SF1	KETOHEXOKINASE
P00034	Integrin signalling pathway	P00916	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IPI	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=69424|UniProtKB=Q99P84	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	12176394	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00047	PDGF signaling pathway	P01153	GSK3	CANLF|Ensembl=ENSCAFG00000004882|UniProtKB=F1PAE3	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00012	Cadherin signaling pathway	P00477	GSK3beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00054	Toll receptor signaling pathway	P01369	MKK1	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_114535|UniProtKB=C3ZHN2	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	MACMU|Ensembl=ENSMMUG00000023046|UniProtKB=F6V829	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05913	Enkephalin release	P05977	G-Protein (s)	CHICK|Ensembl=ENSGALG00000007509|UniProtKB=F1NM72	Uncharacterized protein	ISS	87005246	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00054	Toll receptor signaling pathway	P01368	MKK2	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P06664	Gonadotropin-releasing hormone receptor pathway	P06794	MAP2K1/2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	RCA	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	SCHPO|PomBase=SPAC6G9.07c|UniProtKB=Q92352	Actin-related protein 2/3 complex subunit 4	ISS	5031595	gi	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00018	EGF receptor signaling pathway	P00539	14-3-3	DANRE|ZFIN=ZDB-GENE-030131-779|UniProtKB=Q7ZW20	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00044	Nicotinic acetylcholine receptor signaling pathway	P01095	beta	CAEEL|WormBase=WBGene00000043|UniProtKB=Q93149	Acetylcholine receptor subunit beta-type acr-3	ISS	22213672	PubMed	PTHR18945:SF771	ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 1
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	RAT|RGD=2736|UniProtKB=P35439	Glutamate receptor ionotropic, NMDA 1	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	6264430	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00018	EGF receptor signaling pathway	P00558	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00041	Metabotropic glutamate receptor group I pathway	P01062	mGluR1	MOUSE|MGI=MGI=1351338|UniProtKB=P97772	Metabotropic glutamate receptor 1	ISS	8314195	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00048	PI3 kinase pathway	P01206	14-3-3	ORNAN|Ensembl=ENSOANG00000007305|UniProtKB=F6XW91	Uncharacterized protein	ISS	12615066	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00005	Angiogenesis	P00219	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DICDI|dictyBase=DDB_G0277143|UniProtKB=P36408	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00006	Apoptosis signaling pathway	P00297	NFkappaB	CHICK|Ensembl=ENSGALG00000012304|UniProtKB=Q04861	Nuclear factor NF-kappa-B p105 subunit	ISS	9133421	PubMed	PTHR24169:SF9	NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	CHICK|Ensembl=ENSGALG00000028967|UniProtKB=Q6IMM1	DnaJ homolog subfamily C member 27	ISS			PTHR24073:SF269	DNAJ HOMOLOG SUBFAMILY C MEMBER 27
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	DICDI|dictyBase=DDB_G0286557|UniProtKB=Q8T9S7	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI			PTHR12305:SF79	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P05731	GABA-B receptor II signaling	P05760	AC	HUMAN|HGNC=240|UniProtKB=O60503	Adenylate cyclase type 9	RCA	2491850	PubMed	PTHR11920:SF319	ADENYLATE CYCLASE TYPE 9
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	RAT|RGD=2342|UniProtKB=P08482	Muscarinic acetylcholine receptor M1	IDA	12915051	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	XENTR|Xenbase=XB-GENE-976753|UniProtKB=Q0VFR6	Syntaxin 1A (Brain)	ISS	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P04393	Ras Pathway	P04558	p38	BOVIN|Ensembl=ENSBTAG00000030182|UniProtKB=G3X793	Mitogen-activated protein kinase	ISS	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00006	Apoptosis signaling pathway	P00317	Fos	CANLF|Ensembl=ENSCAFG00000017040|UniProtKB=E2QYK5	Uncharacterized protein	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04393	Ras Pathway	P04552	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IDA	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00049	Parkinson disease	P01208	Hsp70	MONDO|Ensembl=ENSMODG00000012958|UniProtKB=F7DC98	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF239	HEAT SHOCK COGNATE 71 KDA PROTEIN
P00006	Apoptosis signaling pathway	P00260	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00947	Laminin	PANTR|Ensembl=ENSPTRG00000009849|UniProtKB=H2QE84	Laminin, alpha 1	ISS	2538453	PubMed	PTHR10574:SF299	LAMININ SUBUNIT ALPHA-1
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00066	DOPA decarb.	MOUSE|MGI=MGI=94876|UniProtKB=O88533	Aromatic-L-amino-acid decarboxylase	ISS	7567987	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P06587	Nicotine pharmacodynamics pathway	P06604	SLC18A2	MOUSE|MGI=MGI=106677|UniProtKB=Q8BRU6	Synaptic vesicular amine transporter	TAS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00053	T cell activation	P01330	IKK	PANTR|Ensembl=ENSPTRG00000020202|UniProtKB=H2QW34	Uncharacterized protein	ISS	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TRIVA|Gene=TVAG_054030|UniProtKB=A2G1K5	Actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00010	B cell activation	P00398	IP3R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P02725	Allantoin degradation	P02821	Allantoate amidohydrolase	NEUCR|EnsemblGenome=EFNCRG00000001650|UniProtKB=P18407	Allantoicase	ISS			PTHR12045:SF3	ALLANTOICASE-RELATED
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	BOVIN|Ensembl=ENSBTAG00000016420|UniProtKB=Q0VCX4	Catenin beta-1	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P00054	Toll receptor signaling pathway	P01355	AP1	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	HUMAN|HGNC=15916|UniProtKB=Q9P286	Serine/threonine-protein kinase PAK 7	ISS			PTHR24361:SF183	SERINE/THREONINE-PROTEIN KINASE PAK 7
P02723	Adenine and hypoxanthine salvage pathway	P02804	Hypoxanthine phosphoribosyl transferase	MACMU|Ensembl=ENSMMUG00000008303|UniProtKB=F7H6Y5	Uncharacterized protein	ISS			PTHR43340:SF6	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DANRE|ZFIN=ZDB-GENE-030131-1229|UniProtKB=Q6DHS1	Actin, alpha 2, smooth muscle, aorta	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DANRE|ZFIN=ZDB-GENE-000322-1|UniProtKB=Q9I8V1	Actin, alpha 1, skeletal muscle	IEP	14684598	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	MACMU|Ensembl=ENSMMUG00000010173|UniProtKB=F7AGU8	Presenilin	ISS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	RAT|RGD=620137|UniProtKB=P35411	CX3C chemokine receptor 1	ISS	12569158	PubMed	PTHR10489:SF637	CX3C CHEMOKINE RECEPTOR 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	BRAFL|Gene=BRAFLDRAFT_59748|UniProtKB=C3ZEW2	Putative uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF263	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05994	G-protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00554	Shc	MOUSE|MGI=MGI=98296|UniProtKB=P98083	SHC-transforming protein 1	IGI	7798194	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2048|UniProtKB=P25099	Adenosine receptor A1	ISS	11781138	PubMed	PTHR24246:SF1	ADENOSINE RECEPTOR A1
P00057	Wnt signaling pathway	P01434	sFRP	ORNAN|Ensembl=ENSOANG00000005292|UniProtKB=F6Q2D0	Uncharacterized protein	ISS	9096311	PubMed	PTHR11309:SF45	SECRETED FRIZZLED-RELATED PROTEIN 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00029	Huntington disease	P00807	Actin	PHYPA|Gene=PHYPADRAFT_226658|UniProtKB=A9TYG3	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CANLF|Ensembl=ENSCAFG00000008756|UniProtKB=F2Z4N8	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00047	PDGF signaling pathway	P01162	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00010	B cell activation	P00383	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IDA	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00034	Integrin signalling pathway	P00951	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	BOVIN|Ensembl=ENSBTAG00000004093|UniProtKB=Q6B856	Tubulin beta-2B chain	ISS	12932731	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P02771	Pyrimidine Metabolism	P03131	5'-Nucleotidase	MACMU|Ensembl=ENSMMUG00000005442|UniProtKB=F7GPZ7	Uncharacterized protein	RCA	3219501	gi	PTHR11575:SF25	5'-NUCLEOTIDASE
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	CAEEL|WormBase=WBGene00004273|UniProtKB=Q94148	RAB family	ISS			PTHR24073:SF316	IP08727P-RELATED
P00021	FGF signaling pathway	P00627	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	97449291	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00054	Toll receptor signaling pathway	P01352	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	SCHMA|EnsemblGenome=Smp_202970|UniProtKB=G4VLN1	Putative uncharacterized protein Smp_202970	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00048	PI3 kinase pathway	P01199	Galpha	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00053	T cell activation	P01307	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MONDO|Ensembl=ENSMODG00000015246|UniProtKB=F6UJF5	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00057	Wnt signaling pathway	P01443	Phospholipase C	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DICDI|dictyBase=DDB_G0275023|UniProtKB=Q553U6	Putative actin-22	IC	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00019	Endothelin signaling pathway	P00586	Gq	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00029	Huntington disease	P00805	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04578	Rho	PANTR|Ensembl=ENSPTRG00000001112|UniProtKB=H2PZP2	Ras homolog gene family, member C	ISS	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	11591316	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TAKRU|Ensembl=ENSTRUG00000007989|UniProtKB=P68140	Actin, alpha skeletal muscle A	IC	10974003	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P04393	Ras Pathway	P04557	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	IDA	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	IDA	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00005	Angiogenesis	P00243	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	HUMAN|HGNC=1952|UniProtKB=P20309	Muscarinic acetylcholine receptor M3	IDA	11166329	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	DROME|FlyBase=FBgn0013308|UniProtKB=P40808	Ornithine decarboxylase 2	ISS			PTHR11482:SF6	ORNITHINE DECARBOXYLASE 1-RELATED
P00029	Huntington disease	P00805	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000029807|UniProtKB=F6UY56	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF54	PROTOCADHERIN BETA-10
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00049	Parkinson disease	P01219	SAPK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02748	Isoleucine biosynthesis	P02998	Dihydroxyacid dehydratase	STRCO|EnsemblGenome=CAB42671|UniProtKB=O69198	Dihydroxy-acid dehydratase	ISS			PTHR43661:SF3	DIHYDROXY-ACID DEHYDRATASE
P00021	FGF signaling pathway	P00629	PP2A	CHICK|Ensembl=ENSGALG00000009828|UniProtKB=E1C5A3	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01292	RSmads	MOUSE|MGI=MGI=109452|UniProtKB=P70340	Mothers against decapentaplegic homolog 1	TAS	9395284	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	RAT|RGD=1309329|UniProtKB=F1MAD0	Protein Lrp5	ISS	11907044	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00010	B cell activation	P00384	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P02777	Succinate to proprionate conversion	P03161	Methylmalonyl-CoA mutase	THEKO|EnsemblGenome=TK1149|UniProtKB=Q5JIG4	Methylmalonyl-CoA mutase, N-terminus of large subunit	ISS			PTHR43589:SF2	SUBFAMILY NOT NAMED
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CANLF|Ensembl=ENSCAFG00000005662|UniProtKB=E2R907	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	BOVIN|Ensembl=ENSBTAG00000020087|UniProtKB=Q08E45	Calcium/calmodulin-dependent protein kinase II alpha	ISS	12888804	PubMed	PTHR43940:SF5	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	DROME|FlyBase=FBgn0003204|UniProtKB=Q07152	Inosine-5'-monophosphate dehydrogenase	ISS			PTHR11911:SF111	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE
P00048	PI3 kinase pathway	P01196	PDK1	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	11956331	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00029	Huntington disease	P00786	ARF	MACMU|Ensembl=ENSMMUG00000015642|UniProtKB=F6RLV0	ADP-ribosylation factor 6	ISS	11752622	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00049	Parkinson disease	P01211	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02746	Heme biosynthesis	P02982	Protoheme IX farnesyl transferase	SCHPO|PomBase=SPBC365.02c|UniProtKB=Q9Y7Y4	Protoheme IX farnesyltransferase, mitochondrial	ISS			PTHR43448:SF2	PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL
P02738	De novo purine biosynthesis	P02902	ADP reductase	MYCTU|EnsemblGenome=Rv0570|UniProtKB=P9WH77	Vitamin B12-dependent ribonucleoside-diphosphate reductase	ISS			PTHR43371:SF1	SUBFAMILY NOT NAMED
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-7595|UniProtKB=Q6PBR4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00053	T cell activation	P01305	Calmodulin	BOVIN|Ensembl=ENSBTAG00000001575|UniProtKB=F1N6C0	Uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF311	CALMODULIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00557	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	ISS	10799299	PubMed	PTHR10048:SF14	PI-3 KINASE
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	ARATH|TAIR=AT1G36370|UniProtKB=Q84WV0	Serine hydroxymethyltransferase 7	ISS			PTHR11680:SF7	SERINE HYDROXYMETHYLTRANSFERASE 6-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00047	PDGF signaling pathway	P01153	GSK3	DANRE|ZFIN=ZDB-GENE-990714-3|UniProtKB=Q9YH61	Glycogen synthase kinase 3 alpha	ISS	21361340	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IGI	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	MOUSE|MGI=MGI=1321161|UniProtKB=P62715	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	EMENI|EnsemblGenome=CADANIAG00002670|UniProtKB=Q5BH99	G-protein beta subunit [Source:UniProtKB/TrEMBLAcc:O74214]	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00036	Interleukin signaling pathway	P00981	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	CANLF|Ensembl=ENSCAFG00000010476|UniProtKB=F1PS94	Uncharacterized protein	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CAEBR|Gene=CBG20196|UniProtKB=A8XX81	Protein CBR-TBB-2	ISS	12932731	PubMed	PTHR11588:SF84	TUBULIN BETA-2 CHAIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IDA	10693759	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05731	GABA-B receptor II signaling	P05755	Gbeta	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P02785	Valine biosynthesis	P03216	Acetolactate synthase	PYRAE|EnsemblGenome=PAE3300|UniProtKB=Q8ZTD9	Acetolactate synthase	ISS			PTHR18968:SF13	ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	PANTR|Ensembl=ENSPTRG00000015787|UniProtKB=H2QP14	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	RAT|RGD=2520|UniProtKB=P61169	D(2) dopamine receptor	ISS	2137198	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00021	FGF signaling pathway	P00624	14-3-3	RAT|RGD=3980|UniProtKB=P63102	14-3-3 protein zeta/delta	ISS	92362864	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00012	Cadherin signaling pathway	P00470	F-actin	XENTR|Xenbase=XB-GENE-6469705|UniProtKB=Q6P8G3	Actin, alpha sarcomeric/skeletal	ISS	11889126	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05918	p38 MAPK pathway	P06039	MSK2	MACMU|Ensembl=ENSMMUG00000007610|UniProtKB=F6SDH6	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF41	RIBOSOMAL PROTEIN S6 KINASE ALPHA-4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05941	GRK3	MACMU|Ensembl=ENSMMUG00000023790|UniProtKB=F7HT93	Protein-serine/threonine kinase	ISS	10852916	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P00046	Oxidative stress response	P01135	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MONDO|Ensembl=ENSMODG00000023470|UniProtKB=F6T6U1	Uncharacterized protein	ISS	12181435	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P00057	Wnt signaling pathway	P01440	Cadherin	BOVIN|Ensembl=ENSBTAG00000021846|UniProtKB=F1MHH5	Uncharacterized protein	ISS	8120095	PubMed	PTHR24026:SF38	CADHERIN EGF LAG SEVEN-PASS G-TYPE RECEPTOR 3
P04392	P53 pathway feedback loops 1	P04539	p53	BOVIN|Ensembl=ENSBTAG00000005812|UniProtKB=G3X6J7	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00048	PI3 kinase pathway	P01179	PKB	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04572	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CAEEL|WormBase=WBGene00000067|UniProtKB=O45815	ACTin	IC	3487386	PubMed	PTHR11937:SF352	ACTIN
P00054	Toll receptor signaling pathway	P01358	ERK1	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00050	Plasminogen activating cascade	P01251	MMP-3	HUMAN|HGNC=7173|UniProtKB=P08254	Stromelysin-1	IDA	3477804	PubMed	PTHR10201:SF215	STROMELYSIN-1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05731	GABA-B receptor II signaling	P05752	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00057	Wnt signaling pathway	P01456	beta-arrestin	HUMAN|HGNC=10521|UniProtKB=P10523	S-arrestin	IC	11742073	PubMed	PTHR11792:SF15	S-ARRESTIN
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00020	FAS signaling pathway	P00601	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	12972619	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IGI	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00006	Apoptosis signaling pathway	P00314	MKK3	CANLF|Ensembl=ENSCAFG00000018530|UniProtKB=F1PXD3	Uncharacterized protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00048	PI3 kinase pathway	P01206	14-3-3	ORNAN|Ensembl=ENSOANG00000007305|UniProtKB=F6XW91	Uncharacterized protein	ISS	92283271	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00892	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	8235613	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P05913	Enkephalin release	P05976	Enkephalin	BOVIN|Ensembl=ENSBTAG00000004924|UniProtKB=P01211	Proenkephalin-A	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00019	Endothelin signaling pathway	P00590	IP3 R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00006	Apoptosis signaling pathway	P00269	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00012	Cadherin signaling pathway	P00465	TCF/LEF	XENTR|Xenbase=XB-GENE-1031985|UniProtKB=Q6GL68	Transcription factor 7-like 1	ISS	9118222	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	BOVIN|Ensembl=ENSBTAG00000016887|UniProtKB=Q3ZBP7	TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa	ISS			PTHR13218:SF8	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MACMU|Ensembl=ENSMMUG00000017431|UniProtKB=F7HPP3	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04398	p53 pathway feedback loops 2	P04665	AKT	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	ISS	7876156	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00059	p53 pathway	G01575	GADD45	PANTR|Ensembl=ENSPTRG00000021095|UniProtKB=H2QXF6	Growth arrest and DNA-damage-inducible, gamma	ISS	10097101	PubMed	PTHR10411:SF4	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 GAMMA
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	HUMAN|HGNC=1388|UniProtKB=O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	11976940	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P05913	Enkephalin release	P05974	G-Protein (i)	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	IC	12488551	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00060	Ubiquitin proteasome pathway	P01492	E1	MOUSE|MGI=MGI=98891|UniProtKB=P31254	Ubiquitin-like modifier-activating enzyme 1 Y	ISS			PTHR10953:SF169	UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 1 Y
P05915	Opioid proenkephalin pathway	P05993	AC	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	10074940	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	DROME|FlyBase=FBgn0011704|UniProtKB=P48592	Ribonucleoside-diphosphate reductase subunit M2	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	STRPU|Gene=CYIIIA|UniProtKB=P53474	Actin, cytoskeletal 3A	IC	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	DROME|FlyBase=FBgn0004647|UniProtKB=P07207	Neurogenic locus Notch protein	IDA	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00019	Endothelin signaling pathway	P00589	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	XENTR|Xenbase=XB-GENE-961764|UniProtKB=F6W3Y0	Uncharacterized protein	ISS	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MACMU|Ensembl=ENSMMUG00000003405|UniProtKB=F7FE85	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF143	MATRILYSIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	MOUSE|MGI=MGI=96600|UniProtKB=Q62469	Integrin alpha-2	IDA	3487386	PubMed	PTHR23220:SF23	INTEGRIN ALPHA-2
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	RAT|RGD=68376|UniProtKB=Q63150	Dihydropyrimidinase	IDA	9718352	PubMed	PTHR11647:SF50	DIHYDROPYRIMIDINASE
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00018	EGF receptor signaling pathway	P00540	MKK3,6	CANLF|Ensembl=ENSCAFG00000010758|UniProtKB=E2R7W7	Uncharacterized protein	ISS	8622669	PubMed	PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	YEAST|SGD=S000005853|UniProtKB=P19524	Myosin-2	IC			PTHR13140:SF725	DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=1351341|UniProtKB=Q68EF4	Metabotropic glutamate receptor 4	ISS	12351712	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MONDO|Ensembl=ENSMODG00000018204|UniProtKB=F6PGX6	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000008536|UniProtKB=F6WBZ5	Mitogen-activated protein kinase	ISS	12912994	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=15576|UniProtKB=Q8WXR4	Myosin-IIIb	IC			PTHR13140:SF311	MYOSIN-IIIB
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHLRE|EnsemblGenome=CHLREDRAFT_193901|UniProtKB=Q9FXT7	Mitogen-activated protein kinase	IDA			PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00029	Huntington disease	P00790	beta-Tubulin	MOUSE|MGI=MGI=107861|UniProtKB=Q7TMM9	Tubulin beta-2A chain	ISS	9454836	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P00052	TGF-beta signaling pathway	P01275	P38	DROME|FlyBase=FBgn0267339|UniProtKB=P83100	Putative mitogen-activated protein kinase 14C	TAS	11707292	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	ORYSJ|EnsemblGenome=OS05G0491100|UniProtKB=Q6F332	Calmodulin-2	ISS	7514101	PubMed	PTHR23050:SF324	CALMODULIN-2-RELATED
P00010	B cell activation	P00391	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00947	Laminin	HUMAN|HGNC=6486|UniProtKB=P07942	Laminin subunit beta-1	IPI	2538453	PubMed	PTHR10574:SF233	LAMININ SUBUNIT BETA-1
P04398	p53 pathway feedback loops 2	P04658	PTEN	HUMAN|HGNC=12023|UniProtKB=P56180	Putative tyrosine-protein phosphatase TPTE	IGI			PTHR12305:SF32	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE TPTE2-RELATED
P00019	Endothelin signaling pathway	P00591	PLCbeta	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05916	Opioid prodynorphin pathway	P06002	G-protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	ISS	12488551	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00047	PDGF signaling pathway	P01161	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00046	Oxidative stress response	P01135	p38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	TAS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00060	Ubiquitin proteasome pathway	P01491	E2	SCHPO|PomBase=SPBC119.02|UniProtKB=P46595	Ubiquitin-conjugating enzyme E2 4	ISS			PTHR24068:SF74	FI16911P1-RELATED
P00054	Toll receptor signaling pathway	P01346	TLR	HUMAN|HGNC=15633|UniProtKB=Q9NR96	Toll-like receptor 9	ISS			PTHR24373:SF37	TOLL-LIKE RECEPTOR 9
P04393	Ras Pathway	P04556	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01335	jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MONDO|Ensembl=ENSMODG00000001775|UniProtKB=F6WJB1	Uncharacterized protein	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02738	De novo purine biosynthesis	P02898	Phosphoribosylformylglycinamide  synthase	DROME|FlyBase=FBgn0000052|UniProtKB=P35421	Phosphoribosylformylglycinamidine synthase	ISS			PTHR10099:SF1	PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IDA	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00045	Notch signaling pathway	P01113	Pen-2	MOUSE|MGI=MGI=109284|UniProtKB=Q61144	Presenilin-2	IGI	12885769	PubMed	PTHR10202:SF13	PRESENILIN-2
P06587	Nicotine pharmacodynamics pathway	P06604	SLC18A2	RAT|RGD=3694|UniProtKB=Q01827	Synaptic vesicular amine transporter	TAS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00056	VEGF signaling pathway	P01423	p38MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05918	p38 MAPK pathway	P06025	SRF	RAT|RGD=1559787|UniProtKB=D3ZHH8	Protein Srf	ISS	8660892	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P04384	Gamma-aminobutyric acid synthesis	P04482	Glutamate decarboxylase	RAT|RGD=2652|UniProtKB=P18088	Glutamate decarboxylase 1	ISS	2247446	PubMed	PTHR11999:SF57	GLUTAMATE DECARBOXYLASE 1
P02738	De novo purine biosynthesis	P02899	GMP synthase	METAC|EnsemblGenome=MA_4590|UniProtKB=Q8THC7	GMP synthase [glutamine-hydrolyzing] subunit A	ISS			PTHR11922:SF2	GMP SYNTHASE  GLUTAMINE-HYDROLYZING
P00007	Axon guidance mediated by semaphorins	P00340	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BOVIN|Gene=ACTB|UniProtKB=P60712	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00006	Apoptosis signaling pathway	P00260	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	PANTR|Ensembl=ENSPTRG00000000750|UniProtKB=H2PZ19	Uncharacterized protein	ISS	94365697	PubMed	PTHR11958:SF22	EXCITATORY AMINO ACID TRANSPORTER 5
P00005	Angiogenesis	P00227	PLA2	BOVIN|Ensembl=ENSBTAG00000013298|UniProtKB=A4IFJ5	Cytosolic phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IDA	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	TAS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ARATH|TAIR=AT3G18780|UniProtKB=Q96292	Actin-2	IC	11889126	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00807	Actin	PRIPA|Gene=PPA17339|UniProtKB=H3F5B4	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF352	ACTIN
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P02723	Adenine and hypoxanthine salvage pathway	P02807	Deoxyadenosine deaminase	PSEAE|EnsemblGenome=PA0148|UniProtKB=Q9I6Y4	Adenine deaminase	ISS			PTHR43114:SF2	ADENINE DEAMINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04393	Ras Pathway	P04558	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	CHICK|Ensembl=ENSGALG00000009320|UniProtKB=Q4JIM4	Presenilin-1	IDA	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00206	Wnt	BOVIN|Ensembl=ENSBTAG00000014291|UniProtKB=A6H6X8	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00215	Nck	RAT|RGD=1305965|UniProtKB=D4A3M8	Non-catalytic region of tyrosine kinase adaptor protein 2 (Predicted)	ISS	12874226	PubMed	PTHR44108:SF1	CYTOPLASMIC PROTEIN NCK2
P00019	Endothelin signaling pathway	P00587	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P01486	Akt	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	TAS	22081553	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01153	GSK3	PANTR|Ensembl=ENSPTRG00000011049|UniProtKB=H2QGF9	Glycogen synthase kinase 3 alpha	ISS	2164470	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00005	Angiogenesis	P00203	Erk	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00778	NMDA receptor	PANTR|Ensembl=ENSPTRG00000023608|UniProtKB=H2QZZ2	Uncharacterized protein	ISS	11554549	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00053	T cell activation	P01300	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	IXOSC|EnsemblGenome=ISCW009711|UniProtKB=B7Q3T6	THO complex subunit, putative	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P02785	Valine biosynthesis	P03216	Acetolactate synthase	METAC|EnsemblGenome=MA_1354|UniProtKB=Q8TR30	Acetolactate synthase, large subunit	ISS			PTHR18968:SF129	SUBFAMILY NOT NAMED
P00015	Circadian clock system	P00505	Cry	RAT|RGD=735083|UniProtKB=Q32Q86	Cryptochrome-1	ISS	14507900	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CAEEL|WormBase=WBGene00006536|UniProtKB=O17921	TuBulin, Beta	ISS	12932731	PubMed	PTHR11588:SF157	TUBULIN, BETA
P02751	Lysine biosynthesis	P03011	N-succinyldiaminopimelate  aminotransferase	AQUAE|EnsemblGenome=aq_023|UniProtKB=O66442	Acetylornithine aminotransferase	IDA			PTHR11986:SF79	ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL
P00015	Circadian clock system	G01497	cry	HUMAN|HGNC=2385|UniProtKB=Q49AN0	Cryptochrome-2	IEP	14507900	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00021	FGF signaling pathway	P00629	PP2A	MACMU|Ensembl=ENSMMUG00000022443|UniProtKB=F6X3A7	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B	ISS			PTHR11871:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B DELTA ISOFORM
P00049	Parkinson disease	P01212	p38 MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02721	ATP synthesis	P02796	F1 gamma	PANTR|Ensembl=ENSPTRG00000002277|UniProtKB=H2R2Y8	ATP synthase subunit gamma	ISS	2526651	PubMed	PTHR11693:SF22	ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00642	MEK1-2	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000008536|UniProtKB=F6WBZ5	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00758	Phosducin	PANTR|Ensembl=ENSPTRG00000001785|UniProtKB=H2Q0S8	Uncharacterized protein	ISS	10360181	PubMed	PTHR21148:SF17	PHOSDUCIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=1351340|UniProtKB=Q9QYS2	Metabotropic glutamate receptor 3	IDA	9407094	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05941	GRK3	HUMAN|HGNC=290|UniProtKB=P35626	Beta-adrenergic receptor kinase 2	RCA	8288567	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00547	PP2A	ARATH|TAIR=AT2G42500|UniProtKB=Q07100	Serine/threonine-protein phosphatase PP2A-4 catalytic subunit	ISS			PTHR11668:SF318	SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-4 CATALYTIC SUBUNIT
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00018	EGF receptor signaling pathway	P00546	GAP	BOVIN|Ensembl=ENSBTAG00000011829|UniProtKB=F1MHW1	Uncharacterized protein	ISS	90304909	PubMed	PTHR10194:SF60	NEUROFIBROMIN
P00019	Endothelin signaling pathway	P00581	Guanylate cyclase	HUMAN|HGNC=4684|UniProtKB=P33402	Guanylate cyclase soluble subunit alpha-2	RCA			PTHR11920:SF276	GUANYLATE CYCLASE SOLUBLE SUBUNIT ALPHA-2
P00049	Parkinson disease	P01211	ERK	ORYSJ|EnsemblGenome=OS02G0148100|UniProtKB=Q6Z437	Mitogen-activated protein kinase 3	IDA	10514528	PubMed	PTHR24055:SF216	SUBFAMILY NOT NAMED
P02738	De novo purine biosynthesis	P02909	GDP reductase	NEUCR|EnsemblGenome=EFNCRG00000002605|UniProtKB=Q9UW15	Ribonucleoside-diphosphate reductase large chain	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00005	Angiogenesis	P00221	JNK1	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00786	ARF	CANLF|Ensembl=ENSCAFG00000006992|UniProtKB=E2RG67	Uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P00020	FAS signaling pathway	P00611	Gelsolin	MOUSE|MGI=MGI=95851|UniProtKB=P13020	Gelsolin	IGI	9323209	PubMed	PTHR11977:SF29	GELSOLIN
P00050	Plasminogen activating cascade	P01246	Plasmin	PANTR|Ensembl=ENSPTRG00000018774|UniProtKB=H2QU06	Plasminogen	ISS	2318848	PubMed	PTHR24261:SF6	PLASMINOGEN
P00021	FGF signaling pathway	P00641	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05913	Enkephalin release	P05974	G-Protein (i)	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	CHICK|Ensembl=ENSGALG00000006885|UniProtKB=P08642	GTPase HRas	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00034	Integrin signalling pathway	P00922	Collagen	DROME|FlyBase=FBgn0016075|UniProtKB=Q9VMV5	Viking, isoform A	IDA			PTHR24023:SF674	COLLAGEN ALPHA-1 IV  CHAIN-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	HUMAN|HGNC=9508|UniProtKB=P49768	Presenilin-1	IDA	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00029	Huntington disease	P00799	JNK-2	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9441|UniProtKB=P51817	cAMP-dependent protein kinase catalytic subunit PRKX	IC	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00036	Interleukin signaling pathway	P00996	STAT	MOUSE|MGI=MGI=103035|UniProtKB=P42232	Signal transducer and activator of transcription 5B	IC	14662325	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05917	Opioid proopiomelanocortin pathway	P06011	AC	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	DROME|FlyBase=FBgn0010341|UniProtKB=P40793	Cdc42 homolog	ISS	9658176	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00029	Huntington disease	P00807	Actin	ARATH|TAIR=AT5G59370|UniProtKB=P53494	Actin-4	IDA	10974003	PubMed	PTHR11937:SF366	ACTIN-4
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CRYNJ|EnsemblGenome=CNA04650|UniProtKB=Q5KP06	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PHYIT|EnsemblGenome=PITG_06376|UniProtKB=D0N4Q3	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta, putative	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	CHICK|Gene=CHRM4|UniProtKB=P17200	Muscarinic acetylcholine receptor M4	TAS	91373358	PubMed	PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P04398	p53 pathway feedback loops 2	P04657	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	HUMAN|HGNC=5287|UniProtKB=P28222	5-hydroxytryptamine receptor 1B	ISS	11454663	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P04397	p53 pathway by glucose deprivation	P04639	AMPK	CANLF|Ensembl=ENSCAFG00000009986|UniProtKB=E2RH75	Uncharacterized protein	ISS			PTHR10343:SF16	5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1
P00006	Apoptosis signaling pathway	P00269	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	PANTR|Ensembl=ENSPTRG00000013273|UniProtKB=H2QJZ8	Uncharacterized protein	ISS			PTHR42884:SF13	NEUROENDOCRINE CONVERTASE 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	DANRE|ZFIN=ZDB-GENE-050417-59|UniProtKB=Q15KE4	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P05918	p38 MAPK pathway	P06028	MLK2	HUMAN|HGNC=6849|UniProtKB=Q02779	Mitogen-activated protein kinase kinase kinase 10	IDA	9639556	PubMed	PTHR43997:SF5	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 10
P00011	Blood coagulation	P00411	PAI-1	MOUSE|MGI=MGI=97608|UniProtKB=P22777	Plasminogen activator inhibitor 1	ISS	10692390	PubMed	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00019	Endothelin signaling pathway	P00566	ERK	ORYSJ|EnsemblGenome=OS06G0154500|UniProtKB=Q84UI5	Mitogen-activated protein kinase 1	ISS			PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00020	FAS signaling pathway	P00615	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05913	Enkephalin release	P05974	G-Protein (i)	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	XENTR|Xenbase=XB-GENE-957124|UniProtKB=F7BDN8	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00019	Endothelin signaling pathway	P00572	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	94313981	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	STRPU|EnsemblGenome=SPU_006797|UniProtKB=W4XTP5	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00056	VEGF signaling pathway	P01418	Paxillin	HUMAN|HGNC=9718|UniProtKB=P49023	Paxillin	ISS	9182576	PubMed	PTHR24216:SF11	PAXILLIN
P00049	Parkinson disease	P01219	SAPK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00036	Interleukin signaling pathway	P00962	ELK	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	11151091	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04398	p53 pathway feedback loops 2	P04667	p21	PANTR|Ensembl=ENSPTRG00000018107|UniProtKB=H2RFJ9	Uncharacterized protein	ISS	7774811	PubMed	PTHR10265:SF16	CYCLIN-DEPENDENT KINASE INHIBITOR 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	DROME|FlyBase=FBgn0039817|UniProtKB=Q9VA14	Uncharacterized protein	ISS			PTHR23507:SF1	GH23453P-RELATED
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05915	Opioid proenkephalin pathway	P05992	met-Enkephalin	HUMAN|HGNC=8831|UniProtKB=P01210	Proenkephalin-A	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00049	Parkinson disease	P01212	p38 MAPK	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	HALSA|EnsemblGenome=VNG_1153G|UniProtKB=Q9HQI1	Glutamate--tRNA ligase	ISS			PTHR43097:SF5	GLUTAMATE--TRNA LIGASE, CYTOPLASMIC
P04398	p53 pathway feedback loops 2	P04665	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00008	Axon guidance mediated by Slit/Robo	P00355	Rho	ASHGO|EnsemblGenome=AGOS_ABR183W|UniProtKB=Q9HF54	GTP-binding protein RHO1	ISS	11973360	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	HUMAN|HGNC=1402|UniProtKB=Q08289	Voltage-dependent L-type calcium channel subunit beta-2	IDA	20088160	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00048	PI3 kinase pathway	P01200	SHIP	BOVIN|Ensembl=ENSBTAG00000009181|UniProtKB=F1MHB9	Uncharacterized protein	ISS			PTHR12997:SF2	TYPE I INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE
P00003	Alzheimer disease-amyloid secretase pathway	P00093	Tip60	MACMU|Ensembl=ENSMMUG00000009672|UniProtKB=F6YCI6	Uncharacterized protein	ISS			PTHR12345:SF9	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 3
P05914	Nicotine degradation	P05982	UGT1A4	HUMAN|HGNC=12536|UniProtKB=P22310	UDP-glucuronosyltransferase 1-4	TAS	12433823	PubMed	PTHR11926:SF173	UDP-GLUCURONOSYLTRANSFERASE 1-3-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00025	Hedgehog signaling pathway	P00691	CBP	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00018	EGF receptor signaling pathway	P00539	14-3-3	ANOGA|EnsemblGenome=AGAP001151|UniProtKB=Q7PX08	AGAP001151-PA	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	TAKRU|Ensembl=ENSTRUG00000005446|UniProtKB=H2SKZ5	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	PANTR|Ensembl=ENSPTRG00000002413|UniProtKB=H2Q1T1	Integrin beta	ISS	10706722	PubMed	PTHR10082:SF28	INTEGRIN BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000020887|UniProtKB=F1MP22	Uncharacterized protein	ISS	14507926	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01153	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	3755548	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04393	Ras Pathway	P04567	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00049	Parkinson disease	P01241	TH	RAT|RGD=3853|UniProtKB=P04177	Tyrosine 3-monooxygenase	TAS	12480184	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	BOVIN|Ensembl=ENSBTAG00000012927|UniProtKB=A6QLL8	Fructose-bisphosphate aldolase	ISS	6086339	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	CANLF|Ensembl=ENSCAFG00000016077|UniProtKB=E2QW66	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00006	Apoptosis signaling pathway	P00305	Caspase 3	CHICK|Ensembl=ENSGALG00000010638|UniProtKB=O93417	Caspase-3	ISS	9323209	PubMed	PTHR10454:SF198	CASPASE-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	BOVIN|Ensembl=ENSBTAG00000043994|UniProtKB=E1BP29	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04393	Ras Pathway	P04570	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P06002	G-protein	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04398	p53 pathway feedback loops 2	P04651	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P05915	Opioid proenkephalin pathway	P05985	Mu or Delta receptor	MONDO|Ensembl=ENSMODG00000008382|UniProtKB=F7CDR6	Uncharacterized protein (Fragment)	ISS	11259487	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00004	Alzheimer disease-presenilin pathway	P00123	CD44 C-terminal fragment	MOUSE|MGI=MGI=88338|UniProtKB=P15379	CD44 antigen	IDA	14871815	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	BOVIN|Ensembl=ENSBTAG00000006495|UniProtKB=P11017	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00047	PDGF signaling pathway	P01142	p90RSK	HUMAN|HGNC=10430|UniProtKB=Q15418	Ribosomal protein S6 kinase alpha-1	ISS	6755374	gi	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00059	p53 pathway	P01483	Mdm2	MACMU|Ensembl=ENSMMUG00000014193|UniProtKB=F7AKR9	Uncharacterized protein	ISS	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00034	Integrin signalling pathway	P00944	Actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	ISS	14684598	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00006	Apoptosis signaling pathway	P00310	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01020	NSF	PLAF7|EnsemblGenome=PFC0140c|UniProtKB=O77313	N-ethylmaleimide-sensitive fusion protein	ISS	11348590	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00019	Endothelin signaling pathway	P00591	PLCbeta	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	ANOGA|EnsemblGenome=AGAP001478|UniProtKB=Q7PXM3	AGAP001478-PA	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00057	Wnt signaling pathway	P01451	Galpha	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	IDA	9166716	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00029	Huntington disease	P00774	Dynein complex	CANLF|Ensembl=ENSCAFG00000014962|UniProtKB=E2RDH6	Uncharacterized protein	ISS	9454836	PubMed	PTHR10676:SF352	CYTOPLASMIC DYNEIN 2 HEAVY CHAIN 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P06664	Gonadotropin-releasing hormone receptor pathway	P06727	GnRHR	MOUSE|MGI=MGI=95790|UniProtKB=Q01776	Gonadotropin-releasing hormone receptor	RCA	12629106	PubMed	PTHR24241:SF22	GONADOTROPIN-RELEASING HORMONE RECEPTOR
P00006	Apoptosis signaling pathway	P00260	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00048	PI3 kinase pathway	P01202	p85	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000021900|UniProtKB=F1MFK1	Uncharacterized protein	ISS	11880265	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P02725	Allantoin degradation	P02821	Allantoate amidohydrolase	HUMAN|HGNC=17377|UniProtKB=Q8N6M5	Probable allantoicase	ISS			PTHR12045:SF3	ALLANTOICASE-RELATED
P05916	Opioid prodynorphin pathway	P06002	G-protein	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00048	PI3 kinase pathway	G01546	Cyclin d	BOVIN|Ensembl=ENSBTAG00000017514|UniProtKB=Q2KI22	G1/S-specific cyclin-D1	ISS	93330551	PubMed	PTHR10177:SF67	G1/S-SPECIFIC CYCLIN-D1
P00035	Interferon-gamma signaling pathway	P00953	Jak1	MACMU|Ensembl=ENSMMUG00000018566|UniProtKB=F6YLX1	Tyrosine-protein kinase	ISS	11929133	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CHICK|Ensembl=ENSGALG00000011809|UniProtKB=F1NMB0	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MOUSE|MGI=MGI=1346868|UniProtKB=O09110	Dual specificity mitogen-activated protein kinase kinase 3	IC	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	ANOGA|Gene=AgaP_AGAP011360|UniProtKB=Q7Q2V9	AGAP011360-PA (Fragment)	ISS	11742073	PubMed	PTHR11792:SF17	KURTZ ARRESTIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	ORNAN|Ensembl=ENSOANG00000003489|UniProtKB=F7FSE3	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	HUMAN|HGNC=704|UniProtKB=O15143	Actin-related protein 2/3 complex subunit 1B	ISS	9618202	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00057	Wnt signaling pathway	P01456	beta-arrestin	PANTR|Ensembl=ENSPTRG00000004079|UniProtKB=H2R1Z2	Uncharacterized protein	ISS	4757780	gi	PTHR11792:SF22	BETA-ARRESTIN-1
P00029	Huntington disease	P00785	Cytochrome c	SCHPO|PomBase=SPBC29A3.18|UniProtKB=O59680	Cytochrome c1, heme protein, mitochondrial	IDA	15163634	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00034	Integrin signalling pathway	P00916	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00021	FGF signaling pathway	P00623	FGF	HUMAN|HGNC=3679|UniProtKB=Q9HCT0	Fibroblast growth factor 22	ISS			PTHR11486:SF41	FIBROBLAST GROWTH FACTOR 22
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	BOVIN|Ensembl=ENSBTAG00000019988|UniProtKB=F1N2V3	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00010	B cell activation	P00379	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00047	PDGF signaling pathway	P01160	IP3 receptor	CAEBR|Gene=CBG_05938|UniProtKB=H8WGV2	Protein CBR-ITR-1, isoform a	ISS	11007872	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	CHICK|Ensembl=ENSGALG00000001301|UniProtKB=F1NYC4	Clathrin heavy chain	ISS	9388255	PubMed	PTHR10292:SF6	CLATHRIN HEAVY CHAIN 2
P00036	Interleukin signaling pathway	P00983	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	HUMAN|HGNC=4586|UniProtKB=Q13224	Glutamate receptor ionotropic, NMDA 2B	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00025	Hedgehog signaling pathway	P00691	CBP	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	IC	2372396	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P02788	Xanthine and guanine salvage pathway	P03245	Guanine phosphoribosyl transferase	RAT|RGD=1310177|UniProtKB=B2RYS6	Phosphoribosyl transferase domain containing 1	ISS			PTHR43340:SF5	PHOSPHORIBOSYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05944	COMT	MACMU|Ensembl=ENSMMUG00000017152|UniProtKB=F6QFW9	Catechol O-methyltransferase isoform MB-COMT	ISS	12842307	PubMed	PTHR43836:SF3	CATECHOL O-METHYLTRANSFERASE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00029	Huntington disease	P00790	beta-Tubulin	TRIVA|Gene=TVAG_034440|UniProtKB=A2EM81	Beta-tubulin, putative	TAS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00034	Integrin signalling pathway	P00916	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00010	B cell activation	P00376	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	DANRE|ZFIN=ZDB-GENE-031110-4|UniProtKB=Q6NW90	Tubulin, beta 5	ISS	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	HUMAN|HGNC=6093|UniProtKB=P14616	Insulin receptor-related protein	TAS	6754360	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	PANTR|Ensembl=ENSPTRG00000013893|UniProtKB=H2PZY5	Uncharacterized protein	ISS	13645506	gi	PTHR10223:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	RAT|RGD=3188|UniProtKB=Q9QW30	Neurogenic locus notch homolog protein 2	IDA	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CAEEL|WormBase=WBGene00004037|UniProtKB=Q9XWB7	Phosphoinositide phospholipase C	ISS			PTHR10336:SF9	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00012	Cadherin signaling pathway	P00470	F-actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347742|UniProtKB=E9FZ00	Cytoplasmatic actin	ISS	14684598	PubMed	PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00047	PDGF signaling pathway	P01173	STAT	PANTR|Ensembl=ENSPTRG00000009200|UniProtKB=H2QD20	Signal transducer and activator of transcription	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	BOVIN|Ensembl=ENSBTAG00000008059|UniProtKB=P41984	Muscarinic acetylcholine receptor M3	IDA	10069496	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	ISS	10553940	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	IC	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00029	Huntington disease	P00796	Kainate receptor	ORNAN|Ensembl=ENSOANG00000010302|UniProtKB=F6TDQ6	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04398	p53 pathway feedback loops 2	P04665	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02738	De novo purine biosynthesis	P02900	AICAR transformylase	BACSU|EnsemblGenome=BSU06520|UniProtKB=P12048	Bifunctional purine biosynthesis protein PurH	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P02741	Flavin biosynthesis	P02935	GTP cyclohydrolase	GLOVI|Gene=BAC88929|UniProtKB=Q7NLY1	Riboflavin biosynthesis protein RibBA	ISS			PTHR21327:SF32	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	RAT|RGD=2738|UniProtKB=Q00960	Glutamate receptor ionotropic, NMDA 2B	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00019	Endothelin signaling pathway	P00577	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	ISS	96320556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00006	Apoptosis signaling pathway	P00274	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	IC	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04580	TRH Receptor	MOUSE|MGI=MGI=98824|UniProtKB=P21761	Thyrotropin-releasing hormone receptor	ISS	14599121	PubMed	PTHR24243:SF115	THYROTROPIN-RELEASING HORMONE RECEPTOR
P00006	Apoptosis signaling pathway	P00303	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	8837781	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	DROME|FlyBase=FBgn0264492|UniProtKB=P08181	Casein kinase II subunit alpha	ISS	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MOUSE|MGI=MGI=108408|UniProtKB=Q8BXT1	Regulator of G-protein signaling 8	ISS	8756726	PubMed	PTHR10845:SF147	REGULATOR OF G-PROTEIN SIGNALING 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MACMU|Ensembl=ENSMMUG00000010729|UniProtKB=F7G4Y1	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF26	REGULATOR OF G-PROTEIN SIGNALING 7
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00054	Toll receptor signaling pathway	P01365	TAB1	MACMU|Ensembl=ENSMMUG00000012103|UniProtKB=F7H8X1	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform alpha	ISS	10838074	PubMed	PTHR13832:SF533	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00019	Endothelin signaling pathway	P00589	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	IGI	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01465	Ggamma	TAKRU|Ensembl=ENSTRUG00000007253|UniProtKB=H2SZQ1	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P02738	De novo purine biosynthesis	P02889	dGDP kinase	HUMAN|HGNC=7851|UniProtKB=Q13232	Nucleoside diphosphate kinase 3	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P05918	p38 MAPK pathway	P06029	p38beta	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	RCA	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00008	Axon guidance mediated by Slit/Robo	P00351	Cxcr4	RAT|RGD=620465|UniProtKB=O08565	C-X-C chemokine receptor type 4	ISS	4503175	gi	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P00034	Integrin signalling pathway	P00912	Arp2/3	CHICK|Ensembl=ENSGALG00000003820|UniProtKB=E1C8Y3	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00047	PDGF signaling pathway	P01161	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01294	NFAT	MACMU|Ensembl=ENSMMUG00000021843|UniProtKB=F6RNI3	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	XENTR|Xenbase=XB-GENE-492001|UniProtKB=F7BQF6	Uncharacterized protein	ISS			PTHR43521:SF1	ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ARATH|TAIR=AT5G57950|UniProtKB=Q8LAJ4	26S proteasome non-ATPase regulatory subunit 9	ISS			PTHR12651:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9
P00021	FGF signaling pathway	P00633	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P04393	Ras Pathway	P04552	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Ensembl=ENSGALG00000026748|UniProtKB=F1P493	Uncharacterized protein	IEP	10938134	PubMed	PTHR13140:SF728	MYOSIN HEAVY CHAIN, SKELETAL MUSCLE, ADULT
P00053	T cell activation	P01312	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00054	Toll receptor signaling pathway	P01376	Uev1A	PANTR|Ensembl=ENSPTRG00000034248|UniProtKB=H2RE03	Uncharacterized protein	ISS			PTHR43915:SF2	UBIQUITIN-CONJUGATING ENZYME E2 VARIANT 1
P00021	FGF signaling pathway	P00624	14-3-3	XENTR|Xenbase=XB-GENE-970616|UniProtKB=Q6P4Z5	14-3-3 protein zeta	ISS	12865427	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MACMU|Ensembl=ENSMMUG00000012252|UniProtKB=F7GMG0	Syntaxin-12	ISS	10321247	PubMed	PTHR19957:SF88	SYNTAXIN-12
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00927	Rac	ENTHI|EnsemblGenome=EHI_129750|UniProtKB=C4M5Q7	Rho family GTPase	IGI	12932731	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00034	Integrin signalling pathway	P00938	Cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2746|UniProtKB=P31424	Metabotropic glutamate receptor 5	IDA			PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00931	Integrin beta	HUMAN|HGNC=6155|UniProtKB=P05107	Integrin beta-2	IDA	3487386	PubMed	PTHR10082:SF15	INTEGRIN BETA-2
P00012	Cadherin signaling pathway	P00470	F-actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	IC	10974003	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00029	Huntington disease	P00807	Actin	MACMU|Ensembl=ENSMMUG00000002263|UniProtKB=F6VEE0	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00029	Huntington disease	P00805	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04384	Gamma-aminobutyric acid synthesis	P04480	GABA aminotransferase	BOVIN|Gene=ABAT|UniProtKB=Q9BGI0	4-aminobutyrate aminotransferase, mitochondrial	ISS	10989446	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00057	Wnt signaling pathway	P01448	CBP	CAEEL|WormBase=WBGene00010545|UniProtKB=G5EBG3	CBP/p300 homolog	ISS	10664585	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	RCA	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00021	FGF signaling pathway	P00641	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MOUSE|MGI=MGI=95817|UniProtKB=Q8BMF5	Glutamate receptor ionotropic, kainate 4	ISS	12778120	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00054	Toll receptor signaling pathway	P01368	MKK2	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00048	PI3 kinase pathway	P01177	P110ACT	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00023	General transcription regulation	P00668	TFIIB	ARATH|TAIR=AT3G57370|UniProtKB=Q9M2L0	Cyclin family protein	ISS			PTHR11618:SF37	CYCLIN FAMILY PROTEIN-RELATED
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	PANTR|Ensembl=ENSPTRG00000023318|UniProtKB=H2Q4N3	Matrix metallopeptidase 1 (Interstitial collagenase)	ISS	12834808	PubMed	PTHR10201:SF151	INTERSTITIAL COLLAGENASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	TAS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00010	B cell activation	P00402	Jnk	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00056	VEGF signaling pathway	P01419	Ets	MOUSE|MGI=MGI=95455|UniProtKB=P27577	Protein C-ets-1	ISS	15699632	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P02743	Formyltetrahydroformate biosynthesis	P02952	Methylene tetrahydrofolate dehydrogenase	RAT|RGD=1311313|UniProtKB=D4A1Y5	Protein Mthfd2	ISS			PTHR10025:SF39	BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, MITOCHONDRIAL
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IGI	12707323	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01211	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IPI	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CHICK|Ensembl=ENSGALG00000012894|UniProtKB=P30372	Muscarinic acetylcholine receptor M2	IDA	8100450	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00048	PI3 kinase pathway	P01179	PKB	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00045	Notch signaling pathway	P01116	Delta	RAT|RGD=1309740|UniProtKB=D3ZHH1	Delta-like protein 4	ISS	11798067	PubMed	PTHR24044:SF320	DELTA-LIKE PROTEIN 4
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	IC	15621031	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	HUMAN|HGNC=8109|UniProtKB=P11926	Ornithine decarboxylase	ISS			PTHR11482:SF42	ORNITHINE DECARBOXYLASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00018	EGF receptor signaling pathway	P00539	14-3-3	RAT|RGD=61998|UniProtKB=P35213	14-3-3 protein beta/alpha	ISS	1671102	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	TAS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04395	Vasopressin synthesis	P04597	Signal Peptide	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00060	Ubiquitin proteasome pathway	P01491	E2	HUMAN|HGNC=15937|UniProtKB=O00762	Ubiquitin-conjugating enzyme E2 C	ISS			PTHR44189:SF1	UBIQUITIN-CONJUGATING ENZYME E2 C
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	HUMAN|HGNC=3013|UniProtKB=Q14117	Dihydropyrimidinase	IDA	9718352	PubMed	PTHR11647:SF50	DIHYDROPYRIMIDINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00005	Angiogenesis	P00236	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	BOVIN|Ensembl=ENSBTAG00000002295|UniProtKB=F1N177	Uncharacterized protein	ISS	10487205	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00048	PI3 kinase pathway	P01188	Gbetagamma	XENTR|Xenbase=XB-GENE-977853|UniProtKB=F7EBE7	Uncharacterized protein	ISS	10051575	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00057	Wnt signaling pathway	P01465	Ggamma	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00057	Wnt signaling pathway	P01458	Protein Kinase C	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	CANLF|Ensembl=ENSCAFG00000018170|UniProtKB=E2RPM8	Tyrosine-protein kinase receptor	ISS	249616	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00047	PDGF signaling pathway	P01142	p90RSK	CHICK|Ensembl=ENSGALG00000005198|UniProtKB=F1P4J0	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00034	Integrin signalling pathway	P00948	Rho	MONDO|Ensembl=ENSMODG00000000981|UniProtKB=F7ES59	Uncharacterized protein	ISS	12090470	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00030	Hypoxia response via HIF activation	P00819	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00810	GAPDH	ECOLI|EcoGene=EG10367|UniProtKB=P0A9B2	Glyceraldehyde-3-phosphate dehydrogenase A	ISS			PTHR10836:SF76	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE A
P05918	p38 MAPK pathway	P06015	p38gamma	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00007	Axon guidance mediated by semaphorins	P00330	CRAM	HUMAN|HGNC=20637|UniProtKB=Q9BPU6	Dihydropyrimidinase-related protein 5	IEP	10851247	PubMed	PTHR11647:SF58	DIHYDROPYRIMIDINASE-RELATED PROTEIN 5
P04373	5HT1 type receptor mediated signaling pathway	P04407	K+ channel	PANTR|Ensembl=ENSPTRG00000020614|UniProtKB=H2QWR7	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000001187|UniProtKB=F6R8N9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2846|UniProtKB=P28564	5-hydroxytryptamine receptor 1B	IDA	12441358	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P00018	EGF receptor signaling pathway	P00543	ERK1-2	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00053	T cell activation	P01322	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02787	Vitamin B6 metabolism	P03244	Pyridoxal kinase	ECOLI|EcoGene=EG13940|UniProtKB=P77150	Pyridoxal kinase PdxY	TAS	11677609	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05731	GABA-B receptor II signaling	P05754	Ggamma	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	12660731	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00021	FGF signaling pathway	P00624	14-3-3	SCHMA|EnsemblGenome=Smp_002410|UniProtKB=Q95W36	14-3-3 epsilon 2	IGI	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P04393	Ras Pathway	P04568	MKK3/6	MONDO|Ensembl=ENSMODG00000001404|UniProtKB=F7BD74	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P05916	Opioid prodynorphin pathway	P06002	G-protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	IGI	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00036	Interleukin signaling pathway	P00990	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MONDO|Ensembl=ENSMODG00000016310|UniProtKB=F7A659	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF31	FRIZZLED-7
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05752	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	XENTR|Xenbase=XB-GENE-1003788|UniProtKB=Q28GI6	Polymerase (RNA) II (DNA directed) polypeptide L	ISS			PTHR23431:SF3	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5
P00036	Interleukin signaling pathway	P00967	c-fos	CANLF|Ensembl=ENSCAFG00000017040|UniProtKB=E2QYK5	Uncharacterized protein	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04393	Ras Pathway	P04559	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00011	Blood coagulation	P00431	tPA	RAT|RGD=3342|UniProtKB=P19637	Tissue-type plasminogen activator	ISS	137121	gi	PTHR44617:SF1	TISSUE-TYPE PLASMINOGEN ACTIVATOR
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	ARATH|TAIR=AT5G61210|UniProtKB=Q9S7P9	SNAP25 homologous protein SNAP33	IC			PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00019	Endothelin signaling pathway	P00589	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	TAS	12660731	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IGI	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	PANTR|Ensembl=ENSPTRG00000019407|UniProtKB=H2QUY0	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P00012	Cadherin signaling pathway	P00471	Cadherin	MONDO|Ensembl=ENSMODG00000016675|UniProtKB=F7E6I8	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF81	CADHERIN-4
P00021	FGF signaling pathway	P00624	14-3-3	CHICK|Gene_ORFName=RCJMB04_5e12|UniProtKB=Q5F3W6	14-3-3 protein gamma	ISS	1317796	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	RAT|RGD=2746|UniProtKB=P31424	Metabotropic glutamate receptor 5	ISS	8314195	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P04393	Ras Pathway	P04541	p90RSK	PANTR|Ensembl=ENSPTRG00000000387|UniProtKB=H2PYE3	Ribosomal protein S6 kinase	ISS	2779569	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	DANRE|ZFIN=ZDB-GENE-051202-1|UniProtKB=E7F101	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF2	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	IC	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00053	T cell activation	P01300	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CANLF|Ensembl=ENSCAFG00000005662|UniProtKB=E2R907	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00006	Apoptosis signaling pathway	P00302	ATF	RAT|RGD=1304940|UniProtKB=G3V7X9	Activating transcription factor 7 (Predicted), isoform CRA_a	ISS	11390664	PubMed	PTHR19304:SF10	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-7
P00046	Oxidative stress response	P01135	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	TAS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00052	TGF-beta signaling pathway	P01275	P38	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	TAS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MONDO|Ensembl=ENSMODG00000012546|UniProtKB=F6PM16	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00009	Axon guidance mediated by netrin	P00360	DCC/UNC-40	CANLF|Ensembl=ENSCAFG00000000157|UniProtKB=F1PAZ4	Uncharacterized protein	ISS	12798294	PubMed	PTHR44146:SF3	NETRIN RECEPTOR DCC
P00059	p53 pathway	P04630	PP2A	PANTR|Ensembl=ENSPTRG00000017238|UniProtKB=H2QRH7	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00629	PP2A	ARATH|TAIR=AT3G54930|UniProtKB=Q9SV41	Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' epsilon isoform	ISS			PTHR10257:SF3	PP2A-B', ISOFORM B
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	IC	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	IDA	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PANTR|Ensembl=ENSPTRG00000009044|UniProtKB=H2QCR4	Myosin XIX	ISS			PTHR13140:SF289	UNCONVENTIONAL MYOSIN-XIX
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	PANTR|Ensembl=ENSPTRG00000030255|UniProtKB=H2R8C2	Uncharacterized protein	ISS			PTHR10489:SF730	CHEMOKINE XC RECEPTOR 1
P00034	Integrin signalling pathway	P00910	Grb2	DANRE|ZFIN=ZDB-GENE-040426-1975|UniProtKB=Q6PC73	Growth factor receptor-bound protein 2	ISS	http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd	Website	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00047	PDGF signaling pathway	P01173	STAT	RAT|RGD=3772|UniProtKB=P52631	Signal transducer and activator of transcription 3	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04393	Ras Pathway	P04558	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00029	Huntington disease	P00790	beta-Tubulin	DANRE|ZFIN=ZDB-GENE-050522-384|UniProtKB=F1QKY8	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Ensembl=ENSCAFG00000009203|UniProtKB=F1PVZ1	Muscarinic acetylcholine receptor	ISS	91373358	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1203729|UniProtKB=Q61194	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00047	PDGF signaling pathway	P01153	GSK3	STRPU|EnsemblGenome=SPU_009263|UniProtKB=W4Y0P1	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05915	Opioid proenkephalin pathway	P05988	peptide E	HUMAN|HGNC=8831|UniProtKB=P01210	Proenkephalin-A	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00057	Wnt signaling pathway	P01454	betaTrCP	CHICK|Ensembl=ENSGALG00000002229|UniProtKB=F1P5E8	Uncharacterized protein	ISS	10074433	PubMed	PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P00005	Angiogenesis	P00211	GSK3beta	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00049	Parkinson disease	P01214	CHIP	CAEEL|WormBase=WBGene00000500|UniProtKB=G5ECY6	C-term of Hsp70-iNteracting protein (CHIP family)	IDA	12150907	PubMed	PTHR44284:SF1	E3 UBIQUITIN-PROTEIN LIGASE CHIP
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01425	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MACMU|Ensembl=ENSMMUG00000009054|UniProtKB=F7F735	Uncharacterized protein	ISS	20112749	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00036	Interleukin signaling pathway	P00967	c-fos	CANLF|Ensembl=ENSCAFG00000017040|UniProtKB=E2QYK5	Uncharacterized protein	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00009	Axon guidance mediated by netrin	P00359	NFAT	PANTR|Ensembl=ENSPTRG00000013628|UniProtKB=H2R4F5	Uncharacterized protein	ISS	12787506	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P04398	p53 pathway feedback loops 2	P04665	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05731	GABA-B receptor II signaling	P05752	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00968	Ikk	RAT|RGD=621375|UniProtKB=Q9QY78	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	PANTR|Ensembl=ENSPTRG00000008601|UniProtKB=H2QBY1	Arrestin, beta 2	ISS	11742073	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00029	Huntington disease	P00774	Dynein complex	BOVIN|Ensembl=ENSBTAG00000020802|UniProtKB=F1MKJ3	Uncharacterized protein	ISS	9454836	PubMed	PTHR10676:SF255	DYNEIN HEAVY CHAIN 12, AXONEMAL
P00011	Blood coagulation	P00447	FVIIa	PANTR|Gene=F7|UniProtKB=Q2F9P2	Coagulation factor VII	ISS	10518503	gi	PTHR44064:SF1	COAGULATION FACTOR VII
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00012	Cadherin signaling pathway	P00474	Wnt	MACMU|Ensembl=ENSMMUG00000017345|UniProtKB=F7H9C0	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P05916	Opioid prodynorphin pathway	P06000	vasopressin	MOUSE|MGI=MGI=97453|UniProtKB=P35454	Oxytocin-neurophysin 1	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P02725	Allantoin degradation	P02817	Glycerate kinase II	BACSU|EnsemblGenome=BSU40040|UniProtKB=P42100	Glycerate kinase	ISS			PTHR21599:SF0	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01332	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00025	Hedgehog signaling pathway	P00682	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	PANTR|Ensembl=ENSPTRG00000009209|UniProtKB=H2QD27	PSMC3 interacting protein	ISS	20267852	PubMed	PTHR15938:SF0	HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG
P00046	Oxidative stress response	P01135	p38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	TAS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00036	Interleukin signaling pathway	P00965	ERK	RAT|RGD=62087|UniProtKB=P27704	Mitogen-activated protein kinase 6	ISS	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00005	Angiogenesis	P00219	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	RAT|RGD=3425|UniProtKB=P97887	Presenilin-1	TAS	12736250	PubMed	PTHR10202:SF18	PRESENILIN-1
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IDA	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00053	T cell activation	P01332	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IDA	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00008	Axon guidance mediated by Slit/Robo	P00342	Slit	MONDO|Ensembl=ENSMODG00000007165|UniProtKB=F6RCT0	Uncharacterized protein	ISS			PTHR24373:SF15	SLIT HOMOLOG 3 PROTEIN
P04384	Gamma-aminobutyric acid synthesis	P04481	Succinic semialdehyde dehydrogenase	HUMAN|HGNC=408|UniProtKB=P51649	Succinate-semialdehyde dehydrogenase, mitochondrial	IC	12891648	PubMed	PTHR43353:SF5	SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL
P05913	Enkephalin release	P05974	G-Protein (i)	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	YEAST|SGD=S000000467|UniProtKB=P37292	Serine hydroxymethyltransferase, mitochondrial	ISS			PTHR11680:SF21	SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00021	FGF signaling pathway	P00640	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00046	Oxidative stress response	P01135	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	TAS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P02725	Allantoin degradation	P02818	Ureidoglycolate hydrolase	YEAST|SGD=S000001471|UniProtKB=P32459	Ureidoglycolate lyase	ISS			PTHR21221:SF1	UREIDOGLYCOLATE LYASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05734	Synaptic vesicle trafficking	P05776	RIM1alpha/2alpha	BOVIN|Ensembl=ENSBTAG00000020238|UniProtKB=F1N7B7	Uncharacterized protein	ISS	11343654	PubMed	PTHR12157:SF19	REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MONDO|Ensembl=ENSMODG00000001775|UniProtKB=F6WJB1	Uncharacterized protein	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00005	Angiogenesis	P00243	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	BRAFL|Gene=BRAFLDRAFT_121413|UniProtKB=C3ZME5	Putative uncharacterized protein	IEP	12356903	PubMed	PTHR11267:SF106	T-RELATED PROTEIN
P00006	Apoptosis signaling pathway	P00269	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	11204774	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	HUMAN|HGNC=4582|UniProtKB=Q16099	Glutamate receptor ionotropic, kainate 4	ISS	12941441	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00010	B cell activation	P00398	IP3R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00019	Endothelin signaling pathway	P00587	Raf-1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IGI	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01154	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	TAS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01332	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01080	AChE	BRAFL|Gene=BRAFLDRAFT_132597|UniProtKB=C3ZRW7	Carboxylic ester hydrolase	ISS	86008285	PubMed	PTHR11559:SF356	ACETYLCHOLINESTERASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	RAT|RGD=3784|UniProtKB=P61265	Syntaxin-1B	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	MOUSE|MGI=MGI=95809|UniProtKB=P23819	Glutamate receptor 2	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=12782|UniProtKB=P56703	Proto-oncogene Wnt-3	TAS	8717036	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	RAT|RGD=1304556|UniProtKB=P63259	Actin, cytoplasmic 2	ISS	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	IXOSC|EnsemblGenome=ISCW009711|UniProtKB=B7Q3T6	THO complex subunit, putative	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	1333286	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00005	Angiogenesis	P00255	Notch	DROME|FlyBase=FBgn0004647|UniProtKB=P07207	Neurogenic locus Notch protein	ISS			PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P06664	Gonadotropin-releasing hormone receptor pathway	P06779	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	RCA	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00564	Rac	CAEEL|WormBase=WBGene00000424|UniProtKB=Q03206	Ras-related protein ced-10	ISS	12932731	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00060	Ubiquitin proteasome pathway	P01494	19S proteasome	PHYPA|Gene=PHYPADRAFT_170404|UniProtKB=A9TJC3	Predicted protein	ISS			PTHR23073:SF8	26S PROTEASE REGULATORY SUBUNIT 6B
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00007	Axon guidance mediated by semaphorins	P00331	PAK	MOUSE|MGI=MGI=1339975|UniProtKB=O88643	Serine/threonine-protein kinase PAK 1	IDA	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	HUMAN|HGNC=4572|UniProtKB=P42262	Glutamate receptor 2	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00019	Endothelin signaling pathway	P00566	ERK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	ANOGA|EnsemblGenome=AGAP011152|UniProtKB=Q7QHE3	Phosphoinositide phospholipase C	ISS			PTHR10336:SF91	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00047	PDGF signaling pathway	P01157	MAPKAPK2	HUMAN|HGNC=6887|UniProtKB=P49137	MAP kinase-activated protein kinase 2	ISS	9628873	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P04393	Ras Pathway	P04578	Rho	MONDO|Ensembl=ENSMODG00000012981|UniProtKB=F7CS91	Uncharacterized protein	ISS	10556059	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00048	PI3 kinase pathway	P01181	GSK3	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00045	Notch signaling pathway	P01119	NIct	PANTR|Ensembl=ENSPTRG00000010617|UniProtKB=H2QFL8	Notch 3	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	ISS	10974003	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	BOVIN|Gene=PLCD4|UniProtKB=P21671	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	10934033	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IPI	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	TAS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00050	Plasminogen activating cascade	P01255	Plasminogen	BOVIN|Gene=PLG|UniProtKB=P06868	Plasminogen	ISS	2507247	gi	PTHR24261:SF5	PLASMINOGEN
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=2685045|UniProtKB=E9QAN8	Protein Pik3c2b	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00052	TGF-beta signaling pathway	P01292	RSmads	DROME|FlyBase=FBgn0025800|UniProtKB=O96660	Mothers against decapentaplegic homolog	TAS	http://flybase.org/reports/FBrf0190369.html	Website	PTHR13703:SF25	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3
P00011	Blood coagulation	P00429	PN2	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04568	MKK3/6	CHICK|Ensembl=ENSGALG00000004735|UniProtKB=F1NHE1	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00059	p53 pathway	G04694	p110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01395	TFIIE	YEAST|SGD=S000001511|UniProtKB=P36100	Transcription initiation factor IIE subunit alpha	ISS			PTHR13097:SF7	NOVEL PROTEIN SIMILAR TO VERTEBRATE GENERAL TRANSCRIPTION FACTOR IIE POLYPEPTIDE 1 ALPHA 56KDA  GTF2E1
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	TAS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00059	p53 pathway	P04626	GADD45	HUMAN|HGNC=4095|UniProtKB=P24522	Growth arrest and DNA damage-inducible protein GADD45 alpha	IGI	10097101	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P05915	Opioid proenkephalin pathway	P05994	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	DANRE|ZFIN=ZDB-GENE-020125-3|UniProtKB=E7F1V8	Uncharacterized protein	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P05913	Enkephalin release	P05972	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	YEAST|SGD=S000000028|UniProtKB=P31109	Synaptobrevin homolog 1	IC			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00010	B cell activation	P00397	IKK	BOVIN|Ensembl=ENSBTAG00000007599|UniProtKB=Q95KV0	Inhibitor of nuclear factor kappa-B kinase subunit beta	IGI	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00057	Wnt signaling pathway	P01435	SWI/SNF	ANOGA|Gene=AgaP_AGAP010462|UniProtKB=Q7PRH5	AGAP010462-PA (Fragment)	ISS	11532957	PubMed	PTHR10799:SF854	ATP-DEPENDENT HELICASE BRM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	TAS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	ARATH|TAIR=AT5G07880|UniProtKB=Q9SD96	SNAP25 homologous protein SNAP29	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	ANOGA|EnsemblGenome=AGAP005912|UniProtKB=Q7Q6D3	AGAP005912-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00010	B cell activation	P00398	IP3R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00023	General transcription regulation	P00660	RNA Polymerase II	ANOGA|EnsemblGenome=AGAP010321|UniProtKB=Q7Q2H6	AGAP010321-PA	ISS	2187864	PubMed	PTHR11800:SF2	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=893577|UniProtKB=P70452	Syntaxin-4	ISS			PTHR19957:SF97	SYNTAXIN-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01465	Ggamma	MOUSE|MGI=MGI=1336171|UniProtKB=Q9DAS9	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IDA	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04559	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P06959	CCKR signaling map	P07088	RYR1/2/3	HUMAN|HGNC=10483|UniProtKB=P21817	Ryanodine receptor 1	RCA	10590314	PubMed	PTHR13715:SF15	RYANODINE RECEPTOR 1
P00049	Parkinson disease	P01213	Cyclin E	PANTR|Ensembl=ENSPTRG00000020433|UniProtKB=H2R9R9	Uncharacterized protein	ISS	12628165	PubMed	PTHR10177:SF70	G1/S-SPECIFIC CYCLIN-E2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IDA	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P02770	Pyridoxal phosphate salvage pathway	P03123	Pyridoxine-5-phosphate oxidase	YEAST|SGD=S000000239|UniProtKB=P38075	Pyridoxamine 5'-phosphate oxidase	ISS	8849441	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00029	Huntington disease	P00763	Hip-12	MOUSE|MGI=MGI=1921166|UniProtKB=Q8BXG3	Intraflagellar transport protein 57 homolog	IDA			PTHR16011:SF0	INTRAFLAGELLAR TRANSPORT PROTEIN 57 HOMOLOG
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	IDA	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05915	Opioid proenkephalin pathway	P05994	G-protein	NEUCR|EnsemblGenome=EFNCRG00000000159|UniProtKB=F5HH30	Guanine nucleotide-binding protein beta subunit	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	IPI	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00046	Oxidative stress response	P01131	MKP5	HUMAN|HGNC=3074|UniProtKB=Q13202	Dual specificity protein phosphatase 8	TAS			PTHR10159:SF108	DUAL SPECIFICITY PROTEIN PHOSPHATASE 8
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	XENTR|Xenbase=XB-GENE-957124|UniProtKB=F7BDN8	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00034	Integrin signalling pathway	P00922	Collagen	MACMU|Ensembl=ENSMMUG00000019261|UniProtKB=F6SIX4	Uncharacterized protein	ISS	10778855	PubMed	PTHR45047:SF2	COLLAGEN ALPHA-1 XII  CHAIN
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	CANLF|Ensembl=ENSCAFG00000013324|UniProtKB=F1PCS0	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	ORNAN|Ensembl=ENSOANG00000006877|UniProtKB=F7CQF2	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6880|UniProtKB=Q13164	Mitogen-activated protein kinase 7	ISS	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00056	VEGF signaling pathway	P01425	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04393	Ras Pathway	P04556	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02753	Methionine biosynthesis	P03026	O-Succinyl homoserine lyase	SCHPO|PomBase=SPAC23A1.14c|UniProtKB=O42851	Uncharacterized trans-sulfuration enzyme C23A1.14c	ISS			PTHR11808:SF35	SUBFAMILY NOT NAMED
P00023	General transcription regulation	P00660	RNA Polymerase II	SCHPO|PomBase=SPBC337.14|UniProtKB=O74825	DNA-directed RNA polymerase II subunit rpb4	ISS			PTHR21297:SF0	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB4
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	TAKRU|Ensembl=ENSTRUG00000015413|UniProtKB=H2UR30	Uncharacterized protein	ISS			PTHR11681:SF13	SUBFAMILY NOT NAMED
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	STRPU|EnsemblGenome=SPU_026078|UniProtKB=W4ZD41	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF277	SUBFAMILY NOT NAMED
P05918	p38 MAPK pathway	P06020	p38delta	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00059	p53 pathway	P04623	CBP	CAEEL|WormBase=WBGene00010545|UniProtKB=G5EBG3	CBP/p300 homolog	ISS	10664585	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00054	Toll receptor signaling pathway	P01358	ERK1	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00256	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P02726	Aminobutyrate degradation	P02825	4-aminobutyrate aminotransferase	CANLF|Ensembl=ENSCAFG00000019030|UniProtKB=E2R776	Uncharacterized protein	ISS	8133261	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	MONDO|Ensembl=ENSMODG00000018204|UniProtKB=F6PGX6	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00046	Oxidative stress response	P01127	eEF2K	HUMAN|HGNC=24615|UniProtKB=O00418	Eukaryotic elongation factor 2 kinase	TAS	11500363	PubMed	PTHR14187:SF56	EUKARYOTIC ELONGATION FACTOR 2 KINASE
P00008	Axon guidance mediated by Slit/Robo	P00352	DCC	MOUSE|MGI=MGI=94869|UniProtKB=P70211	Netrin receptor DCC	ISS	12798294	PubMed	PTHR44146:SF3	NETRIN RECEPTOR DCC
P00006	Apoptosis signaling pathway	P00269	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000024992|UniProtKB=F6TUR3	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P02749	Leucine biosynthesis	P02999	2-Isopropylmalate synthase	BACTN|EnsemblGenome=BT_1858|UniProtKB=Q8A6L9	2-isopropylmalate synthase	ISS			PTHR10277:SF9	2-ISOPROPYLMALATE SYNTHASE 1, CHLOROPLASTIC-RELATED
P00005	Angiogenesis	P00217	STAT3	HUMAN|HGNC=11364|UniProtKB=P40763	Signal transducer and activator of transcription 3	IDA	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00021	FGF signaling pathway	P00629	PP2A	TAKRU|Ensembl=ENSTRUG00000008018|UniProtKB=H2T5N4	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	DANRE|ZFIN=ZDB-GENE-081006-1|UniProtKB=F1Q9W3	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	BOVIN|Ensembl=ENSBTAG00000006495|UniProtKB=P11017	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IDA			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00053	T cell activation	P01306	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	HUMAN|HGNC=5293|UniProtKB=P28223	5-hydroxytryptamine receptor 2A	ISS	12181435	PubMed	PTHR24247:SF30	5-HYDROXYTRYPTAMINE RECEPTOR 2A
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	BOVIN|Ensembl=ENSBTAG00000000469|UniProtKB=P67774	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	RAT|RGD=3647|UniProtKB=P50229	C-C motif chemokine 3	ISS			PTHR12015:SF91	C-C MOTIF CHEMOKINE 3-RELATED
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04393	Ras Pathway	P04543	MEKK1/4	HUMAN|HGNC=6848|UniProtKB=Q13233	Mitogen-activated protein kinase kinase kinase 1	ISS	12049732	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MACMU|Ensembl=ENSMMUG00000017374|UniProtKB=F7H6T7	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04393	Ras Pathway	P04553	PAK	BOVIN|Ensembl=ENSBTAG00000015670|UniProtKB=E1B7J7	Uncharacterized protein	ISS	7559398	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	RAT|RGD=3380|UniProtKB=P63331	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01173	STAT	MOUSE|MGI=MGI=103035|UniProtKB=P42232	Signal transducer and activator of transcription 5B	ISS	14662325	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00010	B cell activation	P00393	CD19	PANTR|Ensembl=ENSPTRG00000007944|UniProtKB=H2RA93	Uncharacterized protein	ISS	9653091	PubMed	PTHR16674:SF2	B-LYMPHOCYTE ANTIGEN CD19
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MACMU|Ensembl=ENSMMUG00000001458|UniProtKB=F7BKH1	Uncharacterized protein	ISS	12963527	gi	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00034	Integrin signalling pathway	P00925	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04393	Ras Pathway	P04579	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	7680960	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00034	Integrin signalling pathway	P00944	Actin	BOVIN|Gene=ACTG2|UniProtKB=Q5E9B5	Actin, gamma-enteric smooth muscle	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00021	FGF signaling pathway	P00628	JNK1-3	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00037	Ionotropic glutamate receptor pathway	P01015	Glu4	MONDO|Ensembl=ENSMODG00000014746|UniProtKB=F6YN64	Uncharacterized protein (Fragment)	ISS	12497607	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00013	Cell cycle	P00480	Proteasome	YEAST|SGD=S000002255|UniProtKB=Q12377	26S proteasome regulatory subunit RPN6	ISS	97002444	PubMed	PTHR10678:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	MOUSE|MGI=MGI=99578|UniProtKB=Q61616	D(1A) dopamine receptor	ISS	15328036	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00059	p53 pathway	P01486	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	RCA	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04393	Ras Pathway	P04548	ATF2	MOUSE|MGI=MGI=109349|UniProtKB=P16951	Cyclic AMP-dependent transcription factor ATF-2	IDA	7875593	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	CAEEL|WormBase=WBGene00018569|UniProtKB=Q7JP68	cAMP-dependent protein kinase, catalytic subunit-like	IDA	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00046	Oxidative stress response	P01134	cPLA2	PANTR|Ensembl=ENSPTRG00000001787|UniProtKB=H2Q0T0	Phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00030	Hypoxia response via HIF activation	P00818	HIF-1alpha	PANTR|Ensembl=ENSPTRG00000006419|UniProtKB=H2Q8F3	Uncharacterized protein	ISS	9606183	PubMed	PTHR23043:SF7	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA
P04393	Ras Pathway	P04556	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00474	Wnt	MACMU|Ensembl=ENSMMUG00000001325|UniProtKB=F7BGU5	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00036	Interleukin signaling pathway	P00997	Shc	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	IC	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04395	Vasopressin synthesis	P04597	Signal Peptide	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	XENTR|Xenbase=XB-GENE-999257|UniProtKB=F7CEX4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF319	ADENYLATE CYCLASE TYPE 9
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT1G59580|UniProtKB=Q39022	Mitogen-activated protein kinase 2	ISS	9836510	gi	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P02775	Salvage pyrimidine ribonucleotides	P03156	CDP kinase	ARATH|TAIR=AT3G27440|UniProtKB=Q9LTY6	Uridine kinase-like protein 5	ISS			PTHR10285:SF75	URIDINE KINASE-LIKE PROTEIN 5
P00011	Blood coagulation	P00429	PN2	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	ISS	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	IC	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00054	Toll receptor signaling pathway	P01375	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CAEEL|WormBase=WBGene00000063|UniProtKB=P0DM41	Actin-1	IC	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00049	Parkinson disease	P01227	20S proteasome	YEAST|SGD=S000005889|UniProtKB=P21242	Probable proteasome subunit alpha type-7	TAS	12859888	PubMed	PTHR11599:SF10	PROTEASOME SUBUNIT ALPHA TYPE-3
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00048	PI3 kinase pathway	P01197	Caspase-9	PANTR|Ensembl=ENSPTRG00000000200|UniProtKB=H2PY35	Caspase	ISS	8663294	PubMed	PTHR10454:SF157	CASPASE-9
P00006	Apoptosis signaling pathway	P00310	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00591	PLCbeta	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04393	Ras Pathway	P04556	Raf	TAKRU|Ensembl=ENSTRUG00000011625|UniProtKB=H2TXG3	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00059	p53 pathway	P04632	SIRT-1	MACMU|Ensembl=ENSMMUG00000030531|UniProtKB=F7FBX2	Uncharacterized protein	ISS	12006491	PubMed	PTHR11085:SF15	NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	TAKRU|Ensembl=ENSTRUG00000017138|UniProtKB=H2V3X9	Protein Wnt	TAS	11266476	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00021	FGF signaling pathway	P00629	PP2A	HUMAN|HGNC=9310|UniProtKB=Q15173	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform	IGI	11531413	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P05918	p38 MAPK pathway	P06031	p38alpha	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	RCA	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00021	FGF signaling pathway	P00645	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	10802295	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00048	PI3 kinase pathway	P01202	p85	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12701063	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	IC	9199552	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00025	Hedgehog signaling pathway	P00689	Patched	MONDO|Ensembl=ENSMODG00000002769|UniProtKB=F6YGY2	Uncharacterized protein	ISS	8647801	PubMed	PTHR10796:SF61	PROTEIN PATCHED HOMOLOG 1
P04393	Ras Pathway	P04568	MKK3/6	MOUSE|MGI=MGI=1346868|UniProtKB=O09110	Dual specificity mitogen-activated protein kinase kinase 3	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00021	FGF signaling pathway	P00627	ERK1-2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00375	Calmodulin	RAT|RGD=2257|UniProtKB=P62161	Calmodulin	ISS	10487978	PubMed	PTHR23050:SF311	CALMODULIN
P02756	N-acetylglucosamine metabolism	P03036	N-acetylglucosamine-6-phosphate deacetylase	MOUSE|MGI=MGI=2443978|UniProtKB=Q8JZV7	N-acetylglucosamine-6-phosphate deacetylase	ISS			PTHR11113:SF14	N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	CHICK|Ensembl=ENSGALG00000009405|UniProtKB=F1NKF1	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00034	Integrin signalling pathway	P00907	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01414	PLC-gamma	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00046	Oxidative stress response	P01129	JNK1/2	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00034	Integrin signalling pathway	P00922	Collagen	CHICK|Ensembl=ENSGALG00000014965|UniProtKB=F1NRH2	Uncharacterized protein	IDA	10778855	PubMed	PTHR44057:SF5	COLLAGEN ALPHA-1 X  CHAIN
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MONDO|Ensembl=ENSMODG00000012279|UniProtKB=F6YFY5	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF67	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TRIVA|Gene=TVAG_090470|UniProtKB=A2FA04	Actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00021	FGF signaling pathway	P00636	FGFR1-4	PANTR|Ensembl=ENSPTRG00000003003|UniProtKB=H2Q2P3	Fibroblast growth factor receptor	ISS	8089146	PubMed	PTHR24416:SF130	FIBROBLAST GROWTH FACTOR RECEPTOR 2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06779	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	RCA	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00060	Ubiquitin proteasome pathway	P01490	E3	RAT|RGD=1311626|UniProtKB=D3ZXS8	Huntingtin interacting protein 2 (Predicted), isoform CRA_a	ISS			PTHR44020:SF2	UBIQUITIN-CONJUGATING ENZYME E2 K
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DANRE|ZFIN=ZDB-GENE-030131-1229|UniProtKB=Q6DHS1	Actin, alpha 2, smooth muscle, aorta	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02771	Pyrimidine Metabolism	P03126	Nucleoside Phosphorylase	METAC|EnsemblGenome=MA_3242|UniProtKB=Q8TL01	AMP phosphorylase	ISS	11932238	PubMed	PTHR10515:SF0	THYMIDINE PHOSPHORYLASE
P00047	PDGF signaling pathway	P01160	IP3 receptor	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00052	TGF-beta signaling pathway	P01286	TGFbeta	XENTR|Xenbase=XB-GENE-855954|UniProtKB=Q6F2B8	BMP7	ISS	9759503	PubMed	PTHR11848:SF135	BONE MORPHOGENETIC PROTEIN 7
P00010	B cell activation	P00379	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00021	FGF signaling pathway	P00640	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IGI	1171954	gi	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	18021322	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00046	Oxidative stress response	P01135	p38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	TAS	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CANLF|Ensembl=ENSCAFG00000017522|UniProtKB=Q076A4	Myosin-8	ISS	10938134	PubMed	PTHR13140:SF368	MYOSIN-8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MOUSE|MGI=MGI=1915153|UniProtKB=Q9CX84	Regulator of G-protein signaling 19	IDA	8756726	PubMed	PTHR10845:SF145	REGULATOR OF G-PROTEIN SIGNALING 19
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00006	Apoptosis signaling pathway	P00289	FAS	MOUSE|MGI=MGI=95484|UniProtKB=P25446	Tumor necrosis factor receptor superfamily member 6	ISS	10327065	PubMed	PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P00005	Angiogenesis	P00233	CSL	MOUSE|MGI=MGI=96522|UniProtKB=P31266	Recombining binding protein suppressor of hairless	ISS	15187023	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00005	Angiogenesis	P00195	APC	RAT|RGD=2123|UniProtKB=P70478	Adenomatous polyposis coli protein	ISS	8259518	PubMed	PTHR12607:SF11	ADENOMATOUS POLYPOSIS COLI PROTEIN
P00034	Integrin signalling pathway	P00931	Integrin beta	RAT|RGD=1305581|UniProtKB=B2RYB8	Integrin beta	ISS	10330002	PubMed	PTHR10082:SF15	INTEGRIN BETA-2
P00059	p53 pathway	P01480	PTEN	DICDI|dictyBase=DDB_G0286557|UniProtKB=Q8T9S7	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI			PTHR12305:SF79	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00018	EGF receptor signaling pathway	P00539	14-3-3	DANRE|ZFIN=ZDB-GENE-030131-6583|UniProtKB=Q5PRD0	14-3-3 protein beta/alpha-A	ISS	9055384	gi	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P05731	GABA-B receptor II signaling	P05760	AC	MACMU|Ensembl=ENSMMUG00000006253|UniProtKB=F7H582	Uncharacterized protein	ISS	92409599	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	BACSU|EnsemblGenome=BSU00180|UniProtKB=P21335	tRNA-specific adenosine deaminase	ISS			PTHR11079:SF149	TRNA-SPECIFIC ADENOSINE DEAMINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	PHYIT|EnsemblGenome=PITG_06514|UniProtKB=D0N511	Calmodulin	ISS	3885394	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MOUSE|MGI=MGI=95692|UniProtKB=Q07105	Growth/differentiation factor 9	TAS	9759503	PubMed	PTHR11848:SF19	GROWTH/DIFFERENTIATION FACTOR 9
P00021	FGF signaling pathway	P00629	PP2A	MACMU|Ensembl=ENSMMUG00000020819|UniProtKB=F7HSM1	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	SCHMA|EnsemblGenome=Smp_202970|UniProtKB=G4VLN1	Putative uncharacterized protein Smp_202970	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MOUSE|MGI=MGI=95823|UniProtKB=Q03391	Glutamate receptor ionotropic, NMDA 2D	IC	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00057	Wnt signaling pathway	P01443	Phospholipase C	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	IDA	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	RAT|RGD=2732|UniProtKB=P22756	Glutamate receptor ionotropic, kainate 1	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00051	TCA cycle	P01270	Malate Dehydrogenase	METJA|EnsemblGenome=MJ_1425|UniProtKB=Q58820	L-sulfolactate dehydrogenase	IDA	8688087	PubMed	PTHR11091:SF0	SUBFAMILY NOT NAMED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	TAS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04397	p53 pathway by glucose deprivation	P04641	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01443	Phospholipase C	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	IDA	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00021	FGF signaling pathway	P00644	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02726	Aminobutyrate degradation	P02824	Succinate semi-aldehyde dehydrogenase	GLOVI|Gene=BAC90746|UniProtKB=Q7NGT3	Succinate-semialdehyde dehydrogenase	ISS			PTHR43217:SF1	SUCCINATE SEMIALDEHYDE DEHYDROGENASE  NAD P +  SAD
P02738	De novo purine biosynthesis	P02891	GDP kinase	HUMAN|HGNC=20461|UniProtKB=Q9Y5B8	Nucleoside diphosphate kinase 7	ISS			PTHR43109:SF2	NUCLEOSIDE DIPHOSPHATE KINASE 7
P00005	Angiogenesis	P00256	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TAKRU|Ensembl=ENSTRUG00000007989|UniProtKB=P68140	Actin, alpha skeletal muscle A	ISS	11889126	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	RAT|RGD=62004|UniProtKB=Q62915	Peripheral plasma membrane protein CASK	ISS	11430913	PubMed	PTHR23122:SF40	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00046	Oxidative stress response	P01129	JNK1/2	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01447	Dishevelled	MOUSE|MGI=MGI=106613|UniProtKB=Q60838	Segment polarity protein dishevelled homolog DVL-2	ISS	10409711	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P00047	PDGF signaling pathway	P01170	PDGF	CHICK|Ensembl=ENSGALG00000003642|UniProtKB=F1NJJ2	Uncharacterized protein	ISS			PTHR11633:SF3	PLATELET-DERIVED GROWTH FACTOR SUBUNIT A
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	CHICK|Ensembl=ENSGALG00000001301|UniProtKB=F1NYC4	Clathrin heavy chain	ISS	9388255	PubMed	PTHR10292:SF6	CLATHRIN HEAVY CHAIN 2
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000000658|UniProtKB=F6WZD8	Uncharacterized protein	ISS	8120095	PubMed	PTHR44506:SF1	CADHERIN-RELATED FAMILY MEMBER 1
P00012	Cadherin signaling pathway	P00470	F-actin	MACMU|Ensembl=ENSMMUG00000017683|UniProtKB=F6UA63	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00029	Huntington disease	P00796	Kainate receptor	HUMAN|HGNC=4581|UniProtKB=Q13003	Glutamate receptor ionotropic, kainate 3	IDA	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00019	Endothelin signaling pathway	P00587	Raf-1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01162	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347740|UniProtKB=E9FXV8	Cytoplasmatic actin	ISS	14684598	PubMed	PTHR11937:SF277	SUBFAMILY NOT NAMED
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=1306541|UniProtKB=D3ZVF3	Phosphoinositide-3-kinase, class 2, beta polypeptide (Predicted)	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00029	Huntington disease	P00774	Dynein complex	DROME|FlyBase=FBgn0261797|UniProtKB=P37276	Dynein heavy chain, cytoplasmic	IPI	9454836	PubMed	PTHR10676:SF314	CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1
P00021	FGF signaling pathway	P00627	ERK1-2	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	IGI	11707292	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	TAS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00029	Huntington disease	P00786	ARF	RAT|RGD=621279|UniProtKB=P62332	ADP-ribosylation factor 6	ISS	11752622	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	PANTR|Ensembl=ENSPTRG00000018827|UniProtKB=H2RD22	Uncharacterized protein	ISS	600075	OMIM	PTHR10126:SF20	TATA-BOX-BINDING PROTEIN
P00057	Wnt signaling pathway	P01432	Beta-Catenin	PANTR|Ensembl=ENSPTRG00000023062|UniProtKB=H2R2U1	Catenin (Cadherin-associated protein), beta 1, 88kDa	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00036	Interleukin signaling pathway	P00983	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00018	EGF receptor signaling pathway	P00547	PP2A	XENTR|Xenbase=XB-GENE-484003|UniProtKB=Q6P365	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	21071228	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00052	TGF-beta signaling pathway	P01292	RSmads	TAKRU|Ensembl=ENSTRUG00000014344|UniProtKB=H2UI95	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	RAT|RGD=2522|UniProtKB=P30729	D(4) dopamine receptor	IDA	1319557	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P04397	p53 pathway by glucose deprivation	P04641	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IC	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00029	Huntington disease	P00786	ARF	HUMAN|HGNC=692|UniProtKB=P40616	ADP-ribosylation factor-like protein 1	IPI	12932731	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	CAEEL|WormBase=WBGene00002173|UniProtKB=Q9Y0A1	Inositol 1,4,5-trisphosphate receptor itr-1	ISS	1849282	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P04398	p53 pathway feedback loops 2	P04665	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00547	PP2A	IXOSC|EnsemblGenome=ISCW014549|UniProtKB=B7QGY5	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00059	p53 pathway	G04699	BAI-1	RAT|RGD=1309431|UniProtKB=D3ZN99	Brain-specific angiogenesis inhibitor 2 (Predicted)	ISS			PTHR12011:SF41	ADHESION G PROTEIN-COUPLED RECEPTOR B2
P00030	Hypoxia response via HIF activation	P00819	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00007	Axon guidance mediated by semaphorins	P00340	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	RCA	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00036	Interleukin signaling pathway	P00996	STAT	PANTR|Ensembl=ENSPTRG00000009200|UniProtKB=H2QD20	Signal transducer and activator of transcription	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04396	Vitamin D metabolism and pathway	P04606	VDR	RAT|RGD=3959|UniProtKB=P13053	Vitamin D3 receptor	IDA	11705326	PubMed	PTHR24082:SF38	VITAMIN D3 RECEPTOR
P00019	Endothelin signaling pathway	P00566	ERK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	NAS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00045	Notch signaling pathway	P01119	NIct	MOUSE|MGI=MGI=99460|UniProtKB=Q61982	Neurogenic locus notch homolog protein 3	IC	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	CAEEL|WormBase=WBGene00001336|UniProtKB=O62431	Probable glutamine--tRNA ligase	ISS			PTHR43097:SF4	GLUTAMINE--TRNA LIGASE-RELATED
P00005	Angiogenesis	P00223	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01332	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01457	GBeta	DROME|FlyBase=FBgn0004623|UniProtKB=P29829	Guanine nucleotide-binding protein subunit beta-2	ISS	11313908	PubMed	PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00047	PDGF signaling pathway	P01167	Ets	MACMU|Ensembl=ENSMMUG00000008999|UniProtKB=F7EK73	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF30	ETS TRANSLOCATION VARIANT 3
P00029	Huntington disease	P00801	Fos protein	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	TAS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P05912	Dopamine receptor mediated signaling pathway	P05960	VAT2	MOUSE|MGI=MGI=106677|UniProtKB=Q8BRU6	Synaptic vesicular amine transporter	IC	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00021	FGF signaling pathway	P00642	MEK1-2	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00048	PI3 kinase pathway	P01192	p110	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	MOUSE|MGI=MGI=1321159|UniProtKB=P63330	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P02773	S-adenosylmethionine biosynthesis	P03142	Cobalamin-dependent homocysteine transmethylase	CAEEL|WormBase=WBGene00010988|UniProtKB=Q09582	Probable methionine synthase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P02744	Fructose galactose metabolism	P02966	Hexokinase	DROME|FlyBase=FBgn0001186|UniProtKB=Q9W330	Phosphotransferase	RCA			PTHR19443:SF53	HEXOKINASE TYPE 1-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	HUMAN|HGNC=4616|UniProtKB=P49840	Glycogen synthase kinase-3 alpha	TAS	21361340	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00047	PDGF signaling pathway	P01143	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00054	Toll receptor signaling pathway	P01369	MKK1	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P02738	De novo purine biosynthesis	P02908	Phosphoribosylamine glycine ligase	DEIRA|EnsemblGenome=DR_1431|UniProtKB=Q9RUF5	Phosphoribosylamine--glycine ligase	ISS			PTHR43472:SF1	PHOSPHORIBOSYLAMINE--GLYCINE LIGASE
P00019	Endothelin signaling pathway	P00589	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IDA	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00059	p53 pathway	G01579	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	IGI	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CAEEL|WormBase=WBGene00004039|UniProtKB=Q21754	Phosphoinositide phospholipase C	ISS			PTHR10336:SF147	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	ECOLI|EcoGene=EG20257|UniProtKB=P39452	Ribonucleoside-diphosphate reductase 2 subunit alpha	ISS			PTHR11573:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00007	Axon guidance mediated by semaphorins	P00340	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00048	PI3 kinase pathway	P01185	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04393	Ras Pathway	P04542	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00219	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00021	FGF signaling pathway	P00629	PP2A	BOVIN|Ensembl=ENSBTAG00000020598|UniProtKB=F1MY94	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B	ISS	12191994	PubMed	PTHR11871:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B GAMMA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	ANOGA|EnsemblGenome=AGAP001478|UniProtKB=Q7PXM3	AGAP001478-PA	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	RAT|RGD=2026|UniProtKB=P68035	Actin, alpha cardiac muscle 1	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P02721	ATP synthesis	P02791	F1 alpha	BOVIN|Gene=ATP5A1|UniProtKB=P19483	ATP synthase subunit alpha, mitochondrial	ISS	11479684	PubMed	PTHR43089:SF4	ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL
P00019	Endothelin signaling pathway	P00570	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IGI	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	ISS	15621031	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	PANTR|Ensembl=ENSPTRG00000008601|UniProtKB=H2QBY1	Arrestin, beta 2	ISS	9388255	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00010	B cell activation	P00373	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00048	PI3 kinase pathway	P01202	p85	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	IGI	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00005	Angiogenesis	P00188	Ets	XENTR|Xenbase=XB-GENE-6465484|UniProtKB=B3DM35	LOC100170599 protein	ISS	15298723	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00036	Interleukin signaling pathway	P00981	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	DROME|FlyBase=FBgn0002938|UniProtKB=P10676	Neither inactivation nor afterpotential protein C	ISS			PTHR13140:SF666	NEITHER INACTIVATION NOR AFTERPOTENTIAL PROTEIN C
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01181	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00591	PLCbeta	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00019	Endothelin signaling pathway	P00570	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04372	5-Hydroxytryptamine degredation	P04401	Monoamine Oxidase	CANLF|Ensembl=ENSCAFG00000014435|UniProtKB=P58027	Amine oxidase [flavin-containing] A	ISS	90344230	PubMed	PTHR43563:SF3	AMINE OXIDASE  FLAVIN-CONTAINING  A
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	CANLF|Ensembl=ENSCAFG00000004882|UniProtKB=F1PAE3	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00036	Interleukin signaling pathway	P00990	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IC	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	ARATH|TAIR=AT1G13890|UniProtKB=Q9LMG8	Putative SNAP25 homologous protein SNAP30	ISS	10414292	PubMed	PTHR19305:SF7	SNAP25 HOMOLOGOUS PROTEIN SNAP30-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01153	GSK3	DICDI|dictyBase=DDB_G0272110|UniProtKB=P51136	Glycogen synthase kinase-3	ISS	12615961	PubMed	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	ISS	176892	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00029	Huntington disease	P00775	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00799	JNK-2	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MONDO|Ensembl=ENSMODG00000024440|UniProtKB=F7DJJ2	Muscarinic acetylcholine receptor	ISS	91373358	PubMed	PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	RAT|RGD=2739|UniProtKB=Q00961	Glutamate receptor ionotropic, NMDA 2C	ISS	14698601	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00025	Hedgehog signaling pathway	P00692	GSK3	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00057	Wnt signaling pathway	P01443	Phospholipase C	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	IDA	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00036	Interleukin signaling pathway	P00965	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00302	ATF	MOUSE|MGI=MGI=88096|UniProtKB=Q06507	Cyclic AMP-dependent transcription factor ATF-4	ISS	11390664	PubMed	PTHR13044:SF2	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-4
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	P01446	Calcineurin	LEIMA|EnsemblGenome=LmjF.21.1630|UniProtKB=Q4QC21	Putative calcineurin B subunit	IDA	12015605	PubMed	PTHR23056:SF4	PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	TAKRU|Ensembl=ENSTRUG00000002793|UniProtKB=H2S271	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF676	MYOSIN, HEAVY POLYPEPTIDE 2, FAST MUSCLE SPECIFIC
P00008	Axon guidance mediated by Slit/Robo	P00348	Robo	MACMU|Ensembl=ENSMMUG00000002327|UniProtKB=F7C6B3	Uncharacterized protein	ISS			PTHR44096:SF1	ROUNDABOUT HOMOLOG 1
P00049	Parkinson disease	P01227	20S proteasome	MOUSE|MGI=MGI=104885|UniProtKB=P49722	Proteasome subunit alpha type-2	ISS	12859888	PubMed	PTHR11599:SF16	PROTEASOME SUBUNIT ALPHA TYPE-2
P00005	Angiogenesis	P00189	Fzd	MOUSE|MGI=MGI=1888513|UniProtKB=Q9JIP6	Frizzled-2	ISS	11212302	PubMed	PTHR11309:SF34	FRIZZLED-2
P06959	CCKR signaling map	P07236	G17 - Gly	HUMAN|HGNC=4164|UniProtKB=P01350	Gastrin	RCA	9074765	PubMed	PTHR19309:SF0	GASTRIN
P00049	Parkinson disease	P01238	14-3-3	MONDO|Ensembl=ENSMODG00000013658|UniProtKB=F6TY10	Uncharacterized protein	ISS	22165492	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00021	FGF signaling pathway	P00629	PP2A	SCHPO|PomBase=SPCC1739.12|UniProtKB=P36614	Serine/threonine-protein phosphatase ppe1	ISS			PTHR11668:SF24	SERINE/THREONINE-PROTEIN PHOSPHATASE 6 CATALYTIC SUBUNIT
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00038	JAK/STAT signaling pathway	P01027	STAT	MACMU|Ensembl=ENSMMUG00000010705|UniProtKB=F7G8V4	Signal transducer and activator of transcription	ISS	10835485	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00019	Endothelin signaling pathway	P00572	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	RCA	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00564	Rac	ENTHI|EnsemblGenome=EHI_129750|UniProtKB=C4M5Q7	Rho family GTPase	IGI	9601102	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05918	p38 MAPK pathway	P06021	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000005917|UniProtKB=F6QM53	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	TAS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	PANTR|Ensembl=ENSPTRG00000000416|UniProtKB=H2PYG1	Syntaxin 12	ISS	10321247	PubMed	PTHR19957:SF88	SYNTAXIN-12
P00006	Apoptosis signaling pathway	P00291	MEKK1	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	MOUSE|MGI=MGI=102522|UniProtKB=Q8R3Z5	Voltage-dependent L-type calcium channel subunit beta-1	ISS	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00030	Hypoxia response via HIF activation	P00819	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04395	Vasopressin synthesis	P04599	Amidating Enzyme	DROME|FlyBase=FBgn0283510|UniProtKB=Q9V5E1	Peptidyl-alpha-hydroxyglycine alpha-amidating lyase 1	IC	3153462	PubMed	PTHR10680:SF24	PEPTIDYL-ALPHA-HYDROXYGLYCINE ALPHA-AMIDATING LYASE 1
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04456	ProCRF (Pro Corticotropin-Releasing Factor)	BOVIN|Ensembl=ENSBTAG00000033128|UniProtKB=Q95MI6	Corticoliberin	ISS	122560	OMIM	PTHR15035:SF9	CORTICOLIBERIN
P00017	DNA replication	P00538	RNase H	MOUSE|MGI=MGI=1335073|UniProtKB=O70338	Ribonuclease H1	IDA	12667461	PubMed	PTHR10642:SF0	RIBONUCLEASE H1
P04393	Ras Pathway	P04551	RalGDS	MACMU|Ensembl=ENSMMUG00000016399|UniProtKB=F7FZA2	Ral guanine nucleotide dissociation stimulator-like 1	ISS			PTHR23113:SF199	RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 1
P00034	Integrin signalling pathway	P00941	Integrin alpha	RAT|RGD=1596428|UniProtKB=D3ZAC0	Protein Itga2b	ISS	3487386	PubMed	PTHR23220:SF73	INTEGRIN ALPHA-IIB
P00005	Angiogenesis	P00231	HSP27	BOVIN|Ensembl=ENSBTAG00000000434|UniProtKB=P02510	Alpha-crystallin B chain	ISS			PTHR11527:SF37	ALPHA-CRYSTALLIN B CHAIN
P02783	Tryptophan biosynthesis	P03208	Tryptophan synthase B	METAC|EnsemblGenome=MA_3198|UniProtKB=Q8TL44	Tryptophan synthase beta chain 2	ISS			PTHR43565:SF1	TRYPTOPHAN SYNTHASE BETA CHAIN
P00018	EGF receptor signaling pathway	P00557	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00007	Axon guidance mediated by semaphorins	P00338	Neuropilin 1	XENTR|Xenbase=XB-GENE-480688|UniProtKB=A4III3	Nrp1 protein	ISS			PTHR44185:SF1	NEUROPILIN-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=3025|UniProtKB=P21917	D(4) dopamine receptor	IDA	2039532	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00010	B cell activation	P00371	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01162	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00057	Wnt signaling pathway	P01446	Calcineurin	YEAST|SGD=S000001673|UniProtKB=P25296	Calcineurin subunit B	IDA	12015605	PubMed	PTHR23056:SF4	PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1
P06216	SCW signaling pathway	P06329	SAX	DROME|Gene=Dmel_CG1891|UniProtKB=A0A0B4K7J3	Receptor protein serine/threonine kinase	IDA	8134837	PubMed	PTHR23255:SF72	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00019	Endothelin signaling pathway	P00580	ET-RA/B	CHICK|Ensembl=ENSGALG00000007466|UniProtKB=F6SB94	Uncharacterized protein	ISS	9501209	PubMed	PTHR24243:SF103	SUBFAMILY NOT NAMED
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CANLF|Ensembl=ENSCAFG00000008653|UniProtKB=F1PE26	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MOUSE|MGI=MGI=95818|UniProtKB=Q61626	Glutamate receptor ionotropic, kainate 5	ISS	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MONDO|Ensembl=ENSMODG00000009618|UniProtKB=F6REU0	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	STRPU|EnsemblGenome=SPU_002788|UniProtKB=W4XHC0	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=621516|UniProtKB=G3V6P8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	DICDI|dictyBase=DDB_G0269222|UniProtKB=Q8IS21	Ras guanine nucleotide exchange factor B	ISS			PTHR23113:SF163	RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR B
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DICDI|dictyBase=DDB_G0289489|UniProtKB=P07828	Actin-18	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00019	Endothelin signaling pathway	P00572	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	CANLF|Ensembl=ENSCAFG00000003604|UniProtKB=E2R5G6	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF245	RAS-RELATED PROTEIN R-RAS
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	SULSO|EnsemblGenome=SSO0951|UniProtKB=P58178	TATA-box-binding protein	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00053	T cell activation	P01332	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02738	De novo purine biosynthesis	P02891	GDP kinase	CAEEL|WormBase=WBGene00009119|UniProtKB=Q93576	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00047	PDGF signaling pathway	P01148	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	9763606	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00006	Apoptosis signaling pathway	P00297	NFkappaB	HUMAN|HGNC=9955|UniProtKB=Q04206	Transcription factor p65	IDA	10049353	PubMed	PTHR24169:SF1	TRANSCRIPTION FACTOR P65
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DANRE|ZFIN=ZDB-GENE-000322-1|UniProtKB=Q9I8V1	Actin, alpha 1, skeletal muscle	IC	14684598	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00036	Interleukin signaling pathway	P00965	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IC	9298898	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00996	STAT	RAT|RGD=3772|UniProtKB=P52631	Signal transducer and activator of transcription 3	IC	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00053	T cell activation	P01298	NFkappaB	MOUSE|MGI=MGI=97312|UniProtKB=P25799	Nuclear factor NF-kappa-B p105 subunit	IGI	8598461	PubMed	PTHR24169:SF9	NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	CAEBR|Gene=CBG18932|UniProtKB=A8XUD6	Aldehyde dehydrogenase	ISS			PTHR43570:SF16	ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00805	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TRIAD|EnsemblGenome=TriadG56111|UniProtKB=B3RX77	Non-muscle actin 6.2	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00008	Axon guidance mediated by Slit/Robo	P00355	Rho	CHICK|Ensembl=ENSGALG00000016485|UniProtKB=O93468	GTP-binding protein	ISS	13679859	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=1333877|UniProtKB=O88495	Melatonin-related receptor	IDA			PTHR45535:SF1	MELATONIN-RELATED RECEPTOR
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	CAEBR|Gene=CBG_05938|UniProtKB=H8WGV2	Protein CBR-ITR-1, isoform a	ISS	1849282	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00047	PDGF signaling pathway	P01154	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CHICK|Ensembl=ENSGALG00000009844|UniProtKB=P68034	Actin, alpha cardiac muscle 1	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	PANTR|Ensembl=ENSPTRG00000014908|UniProtKB=H2R178	Inosine-5'-monophosphate dehydrogenase	ISS			PTHR11911:SF121	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01072	CHT1	MOUSE|MGI=MGI=1927126|UniProtKB=Q8BGY9	High affinity choline transporter 1	IC			PTHR11819:SF129	HIGH AFFINITY CHOLINE TRANSPORTER 1
P00034	Integrin signalling pathway	P00919	Arf6	PANTR|Ensembl=ENSPTRG00000006324|UniProtKB=H2Q894	ADP-ribosylation factor 6	ISS	12932731	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	IC	91072385	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P02786	Vitamin B6 biosynthesis	P03225	1-Deoxyxylulose-5-phosphate synthase	SYNY3|EnsemblGenome=BAA17089|UniProtKB=P73067	1-deoxy-D-xylulose-5-phosphate synthase	ISS			PTHR43322:SF5	1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MOUSE|MGI=MGI=104589|UniProtKB=P63268	Actin, gamma-enteric smooth muscle	IC	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CAEBR|Gene=CBG01555|UniProtKB=A8WRD7	Mitogen-activated protein kinase	ISS	22138445	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00029	Huntington disease	P00779	TBP	STRPU|EnsemblGenome=SPU_012621|UniProtKB=W4YA56	Uncharacterized protein	IPI	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	10188796	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01150	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	IC	1319556	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	IDA	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04393	Ras Pathway	P04572	JNK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00029	Huntington disease	P00780	Microtubule	DROME|FlyBase=FBgn0003888|UniProtKB=P08841	Tubulin beta-3 chain	IDA	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00054	Toll receptor signaling pathway	P01369	MKK1	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	G01540	BDNF	BOVIN|Ensembl=ENSBTAG00000008134|UniProtKB=Q95106	Brain-derived neurotrophic factor	ISS	11724916	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00036	Interleukin signaling pathway	P00983	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	STRPU|EnsemblGenome=SPU_011000|UniProtKB=W4Y5K3	Uncharacterized protein	ISS			PTHR12458:SF8	CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20
P00049	Parkinson disease	P01211	ERK	MACMU|Ensembl=ENSMMUG00000001187|UniProtKB=F6R8N9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P05916	Opioid prodynorphin pathway	P06002	G-protein	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00010	B cell activation	P00379	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	NEUCR|EnsemblGenome=EFNCRG00000004240|UniProtKB=Q01386	cAMP-dependent protein kinase regulatory subunit	IC	2372396	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00010	B cell activation	P00398	IP3R	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	IGI	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00053	T cell activation	P01330	IKK	CANLF|Ensembl=ENSCAFG00000009588|UniProtKB=E2RNA9	Uncharacterized protein	ISS	14499113	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	RAT|RGD=2740|UniProtKB=Q62645	Glutamate receptor ionotropic, NMDA 2D	ISS	11554549	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P02770	Pyridoxal phosphate salvage pathway	P03122	Pyridoxamine kinase	YEAST|SGD=S000000755|UniProtKB=P39988	Putative pyridoxal kinase BUD16	ISS			PTHR10534:SF2	PYRIDOXAL KINASE
P00047	PDGF signaling pathway	P01150	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00036	Interleukin signaling pathway	P00981	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	TAS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MACMU|Ensembl=ENSMMUG00000023170|UniProtKB=F7FDC0	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF159	NODAL HOMOLOG
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P02769	Purine metabolism	P03117	5'-AMP Deaminase	LEIMA|EnsemblGenome=LmjF.13.0980|UniProtKB=Q4QG56	Putative AMP deaminase	ISS	9477341	PubMed	PTHR11359:SF0	AMP DEAMINASE, ISOFORM K
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	ECOLI|EcoGene=EG11448|UniProtKB=P27550	Acetyl-coenzyme A synthetase	ISS			PTHR24095:SF243	ACETYL-COENZYME A SYNTHETASE
P04393	Ras Pathway	P04546	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00005	Angiogenesis	P00233	CSL	DROME|FlyBase=FBgn0004837|UniProtKB=P28159	Suppressor of hairless protein	ISS			PTHR10665:SF0	SUPPRESSOR OF HAIRLESS PROTEIN
P00019	Endothelin signaling pathway	P00568	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IGI	21157398	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MOUSE|MGI=MGI=1888513|UniProtKB=Q9JIP6	Frizzled-2	TAS	11212302	PubMed	PTHR11309:SF34	FRIZZLED-2
P00049	Parkinson disease	P01236	Casein kinase II	RAT|RGD=621663|UniProtKB=P19139	Casein kinase II subunit alpha	IDA	10617630	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	RAT|RGD=621375|UniProtKB=Q9QY78	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00645	Rac	ORYSJ|Gene=Os01g0229400|UniProtKB=Q9SSX0	Rac-like GTP-binding protein 1	IGI	99415960	PubMed	PTHR24072:SF154	SUBFAMILY NOT NAMED
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	XENTR|Xenbase=XB-GENE-6035431|UniProtKB=F6RJ06	Uncharacterized protein	ISS	9700720	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	TAS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	DICPU|Gene=DICPUDRAFT_47179|UniProtKB=F0ZI47	Putative uncharacterized protein rasB	ISS	7997267	PubMed	PTHR24070:SF206	RAS-LIKE PROTEIN RASB
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00056	VEGF signaling pathway	P01408	Akt/PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00475	Frizzled	PANTR|Ensembl=ENSPTRG00000005632|UniProtKB=H2Q772	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF86	FRIZZLED-10
P00057	Wnt signaling pathway	P01456	beta-arrestin	CANLF|Ensembl=ENSCAFG00000015905|UniProtKB=E2QUH6	Uncharacterized protein	ISS	11742073	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	PSEAE|EnsemblGenome=PA2444|UniProtKB=Q9I138	Serine hydroxymethyltransferase 2	ISS			PTHR11680:SF19	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	HUMAN|HGNC=8590|UniProtKB=Q13153	Serine/threonine-protein kinase PAK 1	ISS	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P02753	Methionine biosynthesis	P03024	Homocysteine transmethylase	PSEAE|EnsemblGenome=PA1843|UniProtKB=Q9I2Q2	Methionine synthase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P00005	Angiogenesis	P00235	c-Fos	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	IDA	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P05731	GABA-B receptor II signaling	P05755	Gbeta	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	BOVIN|Gene=RGS9|UniProtKB=O46469	Regulator of G-protein signaling 9	IDA	9459445	PubMed	PTHR10845:SF170	REGULATOR OF G-PROTEIN SIGNALING 9
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	ISS	12805548	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00029	Huntington disease	P00778	NMDA receptor	XENTR|Xenbase=XB-GENE-494200|UniProtKB=F7CS79	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00059	p53 pathway	P04633	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P02738	De novo purine biosynthesis	P02907	dADP kinase	MACMU|Ensembl=ENSMMUG00000021079|UniProtKB=F7GY40	Uncharacterized protein	ISS			PTHR43109:SF2	NUCLEOSIDE DIPHOSPHATE KINASE 7
P00015	Circadian clock system	G01503	per	CHICK|Ensembl=ENSGALG00000000573|UniProtKB=E1C8E2	Uncharacterized protein	ISS			PTHR11269:SF13	PERIOD CIRCADIAN PROTEIN HOMOLOG 3
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	TAS	12701063	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00053	T cell activation	P01305	Calmodulin	BRAFL|Gene=BRAFLDRAFT_87235|UniProtKB=C3ZEV9	Putative uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00021	FGF signaling pathway	P00638	PLCgamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P06211	BMP/activin signaling pathway-drosophila	P06256	Full-length  BMP orthologous ligand	DROME|FlyBase=FBgn0005590|UniProtKB=P54631	Protein screw	RCA	7958918	PubMed	PTHR11848:SF54	PROTEIN 60A-RELATED
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TRIVA|Gene=TVAG_512800|UniProtKB=A2HNG1	Actin (Fragment)	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	MACMU|Ensembl=ENSMMUG00000010574|UniProtKB=A5A6H2	C-fos	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00047	PDGF signaling pathway	P01145	c-fos	MONDO|Ensembl=ENSMODG00000005927|UniProtKB=F6WX28	Uncharacterized protein	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00015	Circadian clock system	G01503	per	BOVIN|Ensembl=ENSBTAG00000003889|UniProtKB=F1MDK3	Uncharacterized protein	ISS	20570170	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P04373	5HT1 type receptor mediated signaling pathway	P04409	5HT transporter	MACMU|Gene=SLC6A4|UniProtKB=Q9MYX0	Sodium-dependent serotonin transporter	ISS	7681602	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P00055	Transcription regulation by bZIP transcription factor	P01390	TFIIA complex	ORNAN|Ensembl=ENSOANG00000000808|UniProtKB=F6QGV9	Uncharacterized protein	ISS	600519	OMIM	PTHR12694:SF7	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1
P00021	FGF signaling pathway	P00644	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	PANTR|Gene=DRD2|UniProtKB=P60026	D(2) dopamine receptor	ISS	11248120	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P04398	p53 pathway feedback loops 2	P04651	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=620657|UniProtKB=Q8R508	Protocadherin Fat 3	IDA	8120095	PubMed	PTHR24026:SF49	PROTOCADHERIN FAT 3
P00053	T cell activation	P01305	Calmodulin	MOUSE|MGI=MGI=103249|UniProtKB=P62204	Calmodulin	ISS	3885394	PubMed	PTHR23050:SF311	CALMODULIN
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	PANTR|Ensembl=ENSPTRG00000001749|UniProtKB=H2Q0Q4	Uncharacterized protein	ISS	8386525	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00048	PI3 kinase pathway	P01177	P110ACT	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	2837282	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00018	EGF receptor signaling pathway	P00562	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DICDI|dictyBase=DDB_G0286555|UniProtKB=P34147	Rho-related protein racA	ISS	4757952	gi	PTHR24072:SF183	RHO-RELATED PROTEIN RACA
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04393	Ras Pathway	P04570	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12539654	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	HUMAN|HGNC=7884|UniProtKB=Q99466	Neurogenic locus notch homolog protein 4	IDA	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	MACMU|Ensembl=ENSMMUG00000010574|UniProtKB=A5A6H2	C-fos	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	PANTR|Ensembl=ENSPTRG00000015787|UniProtKB=H2QP14	Uncharacterized protein	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	CANLF|Ensembl=ENSCAFG00000009967|UniProtKB=F1PGZ2	Muscarinic acetylcholine receptor	ISS	8100450	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00029	Huntington disease	P00790	beta-Tubulin	STRPU|EnsemblGenome=SPU_007425|UniProtKB=W4XVG9	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00019	Endothelin signaling pathway	P00589	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01179	PKB	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PHYPA|Gene=PHYPADRAFT_225906|UniProtKB=A9TVP1	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00034	Integrin signalling pathway	P00915	PTP-PEST	HUMAN|HGNC=9645|UniProtKB=Q05209	Tyrosine-protein phosphatase non-receptor type 12	IDA	8887669	PubMed	PTHR19134:SF283	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 12
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02748	Isoleucine biosynthesis	P02995	Threonine dehydratase	ORYSJ|Gene=Os03g0713000|UniProtKB=Q8W314	Threonine dehydratase	ISS			PTHR43714:SF1	THREONINE DEHYDRATASE, MITOCHONDRIAL
P00004	Alzheimer disease-presenilin pathway	P00117	E-cadherin C-terminal fragment	XENTR|Xenbase=XB-GENE-482277|UniProtKB=F6QAX3	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P00022	General transcription by RNA polymerase I	P00652	RNA Polymerase I  Complex	DROME|FlyBase=FBgn0003278|UniProtKB=P20028	DNA-directed RNA polymerase I subunit RPA2	ISS	15691654	PubMed	PTHR20856:SF5	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA2
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	ARATH|TAIR=AT4G09320|UniProtKB=P39207	Nucleoside diphosphate kinase 1	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00644	p38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	IGI	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00036	Interleukin signaling pathway	P00976	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00030	Hypoxia response via HIF activation	P00819	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04563	Ets	MONDO|Ensembl=ENSMODG00000004730|UniProtKB=F6Y1Z2	Uncharacterized protein	ISS	15699632	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	RCA			PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00923	Arf1	TAKRU|Ensembl=ENSTRUG00000006254|UniProtKB=H2SS82	Uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00053	T cell activation	P01336	Jnk	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IGI	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05730	Endogenous cannabinoid signaling	P05751	Galpha	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IDA	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00053	T cell activation	P01307	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04393	Ras Pathway	P04548	ATF2	HUMAN|HGNC=784|UniProtKB=P15336	Cyclic AMP-dependent transcription factor ATF-2	ISS	10664585	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00053	T cell activation	P01319	PAK	CHICK|Ensembl=ENSGALG00000000681|UniProtKB=E1C3P6	Uncharacterized protein	ISS	14580336	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00054	Toll receptor signaling pathway	P01367	MKK3	HUMAN|HGNC=6843|UniProtKB=P46734	Dual specificity mitogen-activated protein kinase kinase 3	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00018	EGF receptor signaling pathway	P00547	PP2A	NEUCR|EnsemblGenome=EFNCRG00000003366|UniProtKB=Q7S7P2	Serine/threonine protein phosphatase 2A	ISS			PTHR10257:SF3	PP2A-B', ISOFORM B
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00178	BACE-1 pro-domain	PANTR|Ensembl=ENSPTRG00000004324|UniProtKB=H2Q4U8	Beta-site APP-cleaving enzyme 1	ISS	10956649	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MOUSE|MGI=MGI=2152453|UniProtKB=Q2NL51	Glycogen synthase kinase-3 alpha	ISS	183955	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DROME|FlyBase=FBgn0000042|UniProtKB=P10987	Actin-5C	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	P01457	GBeta	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IDA	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00012	Cadherin signaling pathway	P00465	TCF/LEF	HUMAN|HGNC=11640|UniProtKB=Q9HCS4	Transcription factor 7-like 1	ISS	11266476	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00920	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	ORNAN|Ensembl=ENSOANG00000013961|UniProtKB=F6VPY1	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00034	Integrin signalling pathway	P00922	Collagen	MACMU|Ensembl=ENSMMUG00000011582|UniProtKB=F6PPA4	Uncharacterized protein	ISS	10778855	PubMed	PTHR44929:SF1	COLLAGEN ALPHA-1 XV  CHAIN
P00054	Toll receptor signaling pathway	P01369	MKK1	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	MOUSE|MGI=MGI=105083|UniProtKB=P51906	Excitatory amino acid transporter 3	ISS	94365697	PubMed	PTHR11958:SF69	EXCITATORY AMINO ACID TRANSPORTER 3
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IDA	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MACMU|Ensembl=ENSMMUG00000014754|UniProtKB=F7G124	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF721	MYOSIN-6
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	MOUSE|MGI=MGI=1353451|UniProtKB=P47739	Aldehyde dehydrogenase, dimeric NADP-preferring	IC	14724059	PubMed	PTHR43570:SF15	ALDEHYDE DEHYDROGENASE, DIMERIC NADP-PREFERRING
P00029	Huntington disease	P00810	GAPDH	ORYSJ|EnsemblGenome=OS04G0459500|UniProtKB=Q7X8A1	Glyceraldehyde-3-phosphate dehydrogenase	ISS			PTHR43148:SF5	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE GAPA1, CHLOROPLASTIC-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04558	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00029	Huntington disease	G01531	BDNF	CHICK|Ensembl=ENSGALG00000012163|UniProtKB=P25429	Brain-derived neurotrophic factor	IDA	11724916	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00054	Toll receptor signaling pathway	P01349	ECSIT	HUMAN|HGNC=29548|UniProtKB=Q9BQ95	Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial	ISS			PTHR13113:SF1	EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAY, MITOCHONDRIAL
P00005	Angiogenesis	P00243	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00018	EGF receptor signaling pathway	P00562	p38	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	4506785	gi	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00021	FGF signaling pathway	P00644	p38	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	4506785	gi	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00005	Angiogenesis	P00219	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00005	Angiogenesis	P00223	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	IDA	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000020588|UniProtKB=F7C0E0	Uncharacterized protein	ISS	11554554	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P04398	p53 pathway feedback loops 2	P04657	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00972	MNK1/2	BOVIN|Gene=MKNK1|UniProtKB=Q58D94	MAP kinase-interacting serine/threonine-protein kinase 1	ISS	97299868	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	IDA	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00034	Integrin signalling pathway	P00951	Jnk	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00053	T cell activation	P01298	NFkappaB	BOVIN|Ensembl=ENSBTAG00000006017|UniProtKB=F6Q9X9	Uncharacterized protein	ISS	9133421	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BOVIN|Ensembl=ENSBTAG00000005714|UniProtKB=Q3ZC07	Actin, alpha cardiac muscle 1	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00006	Apoptosis signaling pathway	P00310	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00219	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=71083|UniProtKB=P30940	5-hydroxytryptamine receptor 1F	IDA	12441358	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=8153|UniProtKB=P41143	Delta-type opioid receptor	IDA	12093103	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	HUMAN|HGNC=4044|UniProtKB=O60353	Frizzled-6	TAS	8717036	PubMed	PTHR11309:SF75	FRIZZLED-6
P04398	p53 pathway feedback loops 2	P04657	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04393	Ras Pathway	P04572	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01446	Calcineurin	PANTR|Ensembl=ENSPTRG00000016315|UniProtKB=H2QPY6	Serine/threonine-protein phosphatase	ISS	12015605	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02788	Xanthine and guanine salvage pathway	P03248	Deoxyguanosine phosphorylase	SCHPO|PomBase=SPAC1805.16c|UniProtKB=Q9UTG1	Putative purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00010	B cell activation	P00373	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	RAT|RGD=2735|UniProtKB=Q63273	Glutamate receptor ionotropic, kainate 5	ISS	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P05915	Opioid proenkephalin pathway	P05989	leu-Enkephalin	BOVIN|Ensembl=ENSBTAG00000004924|UniProtKB=P01211	Proenkephalin-A	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=2136757|UniProtKB=Q91Y01	MCG141286	IDA	8120095	PubMed	PTHR24028:SF91	PROTOCADHERIN BETA-11
P00047	PDGF signaling pathway	P01162	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00010	B cell activation	P00369	MEKK	MACMU|Ensembl=ENSMMUG00000016751|UniProtKB=F7AIB6	Mitogen-activated protein kinase kinase kinase 3 isoform 1	ISS	11730323	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00034	Integrin signalling pathway	P00906	Rap1	RAT|RGD=620577|UniProtKB=Q62636	Ras-related protein Rap-1b	IPI	10476970	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	RAT|RGD=620761|UniProtKB=Q9R172	Neurogenic locus notch homolog protein 3	IDA	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00019	Endothelin signaling pathway	P00580	ET-RA/B	MACMU|Ensembl=ENSMMUG00000003659|UniProtKB=F7HSF3	Endothelin-1 receptor isoform a	ISS	91080923	PubMed	PTHR24243:SF31	ENDOTHELIN-1 RECEPTOR
P02729	Ascorbate degradation	P02851	L-ribulose-5-phosphate-4-epimerase	ECOLI|EcoGene=EG12287|UniProtKB=P37680	L-ribulose-5-phosphate 4-epimerase SgbE	ISS			PTHR22789:SF8	L-RIBULOSE-5-PHOSPHATE 4-EPIMERASE SGBE
P04397	p53 pathway by glucose deprivation	P04641	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	PANTR|Ensembl=ENSPTRG00000018511|UniProtKB=H2QTK7	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT3G45640|UniProtKB=Q39023	Mitogen-activated protein kinase 3	ISS	9836510	gi	PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05730	Endogenous cannabinoid signaling	P05751	Galpha	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02741	Flavin biosynthesis	P02934	Riboflavin kinase	SCHPO|PomBase=SPCC18.16c|UniProtKB=O74866	Riboflavin kinase	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	PSEAE|EnsemblGenome=PA3504|UniProtKB=Q9HYA5	Probable aldehyde dehydrogenase	IC			PTHR11699:SF222	PHENYLACETALDEHYDE DEHYDROGENASE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	IXOSC|EnsemblGenome=ISCW009711|UniProtKB=B7Q3T6	THO complex subunit, putative	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00012	Cadherin signaling pathway	P00474	Wnt	DANRE|ZFIN=ZDB-GENE-990415-279|UniProtKB=P51029	Protein Wnt-8b	IDA	11266476	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	MACMU|Ensembl=ENSMMUG00000010173|UniProtKB=F7AGU8	Presenilin	ISS	12736250	PubMed	PTHR10202:SF18	PRESENILIN-1
P00034	Integrin signalling pathway	P00907	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	97442349	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ARATH|TAIR=AT3G46520|UniProtKB=P53497	Actin-12	IDA			PTHR11937:SF276	ACTIN-12
P02724	Alanine biosynthesis	P02815	Branched chain amino acid aminotransferase	PANTR|Ensembl=ENSPTRG00000011258|UniProtKB=H2QGS7	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF39	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, MITOCHONDRIAL
P06214	GBB signaling pathway	P06303	LACK	DROME|FlyBase=FBgn0029006|UniProtKB=Q9V853	E3 ubiquitin-protein ligase Smurf1	IEA	11252892	PubMed	PTHR11254:SF395	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	DANRE|ZFIN=ZDB-GENE-991119-4|UniProtKB=Q9W6T7	Presenilin-1	IDA	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00021	FGF signaling pathway	P00638	PLCgamma	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	MACMU|Ensembl=ENSMMUG00000019817|UniProtKB=F7FY63	Protein-serine/threonine kinase	RCA			PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	RAT|RGD=1306522|UniProtKB=Q4L0E8	Regulator of G-protein signaling 18	ISS	8756726	PubMed	PTHR10845:SF155	REGULATOR OF G-PROTEIN SIGNALING 18
P00010	B cell activation	P00380	fos	RAT|RGD=2626|UniProtKB=P12841	Proto-oncogene c-Fos	TAS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00036	Interleukin signaling pathway	P00989	Ets	XENTR|Xenbase=XB-GENE-479615|UniProtKB=C0KXH8	SPIB	ISS	8970723	PubMed	PTHR11849:SF174	TRANSCRIPTION FACTOR SPI-B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	PANTR|Ensembl=ENSPTRG00000001102|UniProtKB=H2QZR9	RAP1A, member of RAS oncogene family	ISS	8576107	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Ensembl=ENSPTRG00000013825|UniProtKB=H2RAK4	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	DROME|FlyBase=FBgn0002938|UniProtKB=P10676	Neither inactivation nor afterpotential protein C	ISS			PTHR13140:SF666	NEITHER INACTIVATION NOR AFTERPOTENTIAL PROTEIN C
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01242	Casein kinase I	MOUSE|MGI=MGI=1920014|UniProtKB=Q8BVP5	Casein kinase I isoform gamma-2	IDA	10617630	PubMed	PTHR11909:SF157	CASEIN KINASE I ISOFORM GAMMA-2
P02763	Peptidoglycan biosynthesis	P03084	UDP-N-acetylmuramoylalanyl-D-glutamate 2,6-diaminopimelate ligase	GLOVI|Gene=BAC92267|UniProtKB=Q7NDB0	Cyanophycin synthetase	ISS			PTHR23135:SF18	SUBFAMILY NOT NAMED
P05731	GABA-B receptor II signaling	P05760	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00011	Blood coagulation	P00404	PAR-1	MOUSE|MGI=MGI=101802|UniProtKB=P30558	Proteinase-activated receptor 1	ISS	2506485	gi	PTHR24232:SF20	PROTEINASE-ACTIVATED RECEPTOR 1
P04395	Vasopressin synthesis	P04594	Neurophysin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00641	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00049	Parkinson disease	P01211	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	11251832	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00059	p53 pathway	P04635	Sumo-1 ligase	TAKRU|Ensembl=ENSTRUG00000011501|UniProtKB=H2TWH7	Small ubiquitin-related modifier	ISS			PTHR10562:SF11	SMALL UBIQUITIN-RELATED MODIFIER 2-RELATED
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MACMU|Ensembl=ENSMMUG00000012252|UniProtKB=F7GMG0	Syntaxin-12	ISS	14570579	PubMed	PTHR19957:SF88	SYNTAXIN-12
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	IDA	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P02738	De novo purine biosynthesis	P02905	Amidophosphoribosyl transferase	PSEAE|EnsemblGenome=PA3108|UniProtKB=Q51342	Amidophosphoribosyltransferase	ISS			PTHR11907:SF13	AMIDOPHOSPHORIBOSYLTRANSFERASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	11832947	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05913	Enkephalin release	P05972	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	TAKRU|Ensembl=ENSTRUG00000002793|UniProtKB=H2S271	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF676	MYOSIN, HEAVY POLYPEPTIDE 2, FAST MUSCLE SPECIFIC
P00036	Interleukin signaling pathway	P00980	IRS1/2	HUMAN|HGNC=6125|UniProtKB=P35568	Insulin receptor substrate 1	IC	15110093	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00010	B cell activation	P00371	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	MACMU|Ensembl=ENSMMUG00000020513|UniProtKB=F7B2V1	Phosphorylase b kinase regulatory subunit alpha, liver isoform	ISS	10487978	PubMed	PTHR10749:SF5	PHOSPHORYLASE B KINASE REGULATORY SUBUNIT ALPHA, LIVER ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00049	Parkinson disease	P01227	20S proteasome	DROME|FlyBase=FBgn0263121|UniProtKB=Q9XZJ4	Proteasome subunit alpha type-6	TAS	12859888	PubMed	PTHR11599:SF11	PROTEASOME SUBUNIT ALPHA TYPE-6
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	STRPU|Gene=CYIIIB|UniProtKB=P18499	Actin, cytoskeletal 3B	IC	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01286	TGFbeta	HUMAN|HGNC=11843|UniProtKB=O43897	Tolloid-like protein 1	TAS	9759503	PubMed	PTHR43978:SF4	TOLLOID-LIKE PROTEIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00021	FGF signaling pathway	P00634	MEKK1-5	MACMU|Ensembl=ENSMMUG00000016751|UniProtKB=F7AIB6	Mitogen-activated protein kinase kinase kinase 3 isoform 1	ISS	11730323	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00018	EGF receptor signaling pathway	P00559	MEK1-2	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IGI	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00797	p53	MOUSE|MGI=MGI=98834|UniProtKB=P02340	Cellular tumor antigen p53	TAS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	IDA	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00047	PDGF signaling pathway	P01168	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04393	Ras Pathway	P04556	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01161	Raf	TAKRU|Ensembl=ENSTRUG00000006611|UniProtKB=H2SV11	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00018	EGF receptor signaling pathway	P00546	GAP	ORNAN|Ensembl=ENSOANG00000014753|UniProtKB=F7EPN2	Uncharacterized protein (Fragment)	ISS	15489039	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00048	PI3 kinase pathway	P01192	p110	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01145	c-fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00018	EGF receptor signaling pathway	P00549	EGF	MOUSE|MGI=MGI=88068|UniProtKB=P31955	Amphiregulin	IGI	6753108	gi	PTHR10740:SF12	AMPHIREGULIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P02787	Vitamin B6 metabolism	P03236	Pyridoxamine phosphate oxidase	MACMU|Ensembl=ENSMMUG00000003325|UniProtKB=F7EHD9	Pyridoxine-5'-phosphate oxidase	ISS	15182361	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IGI	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00006	Apoptosis signaling pathway	P00310	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01320	PLC-gamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00036	Interleukin signaling pathway	P00970	Interleukin	BOVIN|Ensembl=ENSBTAG00000015953|UniProtKB=Q9XSV9	Interleukin-13	IC			PTHR45413:SF1	INTERLEUKIN-13
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00568	PKC	DANRE|ZFIN=ZDB-GENE-041001-104|UniProtKB=Q5TZD4	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00005	Angiogenesis	P00219	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05913	Enkephalin release	P05972	PKA	CAEEL|WormBase=WBGene00002189|UniProtKB=P21137	cAMP-dependent protein kinase catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P06959	CCKR signaling map	P07119	MAPK3	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	RCA	12488236	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P06959	CCKR signaling map	P07090	MAPK8-10	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	RCA	20150185	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01095	beta	CAEBR|Gene=CBG01814|UniProtKB=A8WQR5	Protein CBR-LEV-1	ISS	22213672	PubMed	PTHR18945:SF747	ACETYLCHOLINE RECEPTOR SUBUNIT BETA-TYPE LEV-1
P00036	Interleukin signaling pathway	P00965	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IC	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00807	Actin	SCHMA|EnsemblGenome=Smp_161920|UniProtKB=G4VSW5	Putative actin	IDA	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00005	Angiogenesis	P00238	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00049	Parkinson disease	P01230	Src kinase	PANTR|Ensembl=ENSPTRG00000013474|UniProtKB=H2QKB4	Tyrosine-protein kinase	ISS	8054685	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	PANTR|Ensembl=ENSPTRG00000020535|UniProtKB=H2R9Q1	TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa	ISS			PTHR15137:SF9	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	MACMU|Ensembl=ENSMMUG00000013664|UniProtKB=F7GFT6	Serine/threonine-protein phosphatase	ISS	8392016	PubMed	PTHR11668:SF204	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-GAMMA CATALYTIC SUBUNIT
P04395	Vasopressin synthesis	P04593	Glycopeptide	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	IC	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00021	FGF signaling pathway	P00643	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00020	FAS signaling pathway	P00599	Caspase3	HUMAN|HGNC=1504|UniProtKB=P42574	Caspase-3	IGI	7983002	PubMed	PTHR10454:SF198	CASPASE-3
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	PANTR|Ensembl=ENSPTRG00000006890|UniProtKB=H2Q943	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00005	Angiogenesis	P00186	FGFR-1	BOVIN|Ensembl=ENSBTAG00000015457|UniProtKB=A4IFL5	Fibroblast growth factor receptor	ISS	2544996	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00947	Laminin	MOUSE|MGI=MGI=99913|UniProtKB=Q61092	Laminin subunit gamma-2	IPI	2538453	PubMed	PTHR10574:SF313	LAMININ SUBUNIT GAMMA-2
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_114976|UniProtKB=C3YP58	Putative uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00018	EGF receptor signaling pathway	P00551	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01135	p38	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	TAS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	10395542	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	IDA	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00219	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	IC	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	CAEBR|Gene=CBG02162|UniProtKB=A8WS33	Protein CBG02162	ISS	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00019	Endothelin signaling pathway	P00566	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	10875333	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	RAT|RGD=628816|UniProtKB=G3V6L1	Frizzled homolog 6 (Drosophila)	ISS	11212302	PubMed	PTHR11309:SF75	FRIZZLED-6
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	MOUSE|MGI=MGI=95818|UniProtKB=Q61626	Glutamate receptor ionotropic, kainate 5	ISS	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00034	Integrin signalling pathway	P00916	Ras	MOUSE|MGI=MGI=98179|UniProtKB=P10833	Ras-related protein R-Ras	IPI	7997267	PubMed	PTHR24070:SF245	RAS-RELATED PROTEIN R-RAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05731	GABA-B receptor II signaling	P05760	AC	BOVIN|Ensembl=ENSBTAG00000014600|UniProtKB=E1BQ12	Uncharacterized protein	ISS	8163524	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00036	Interleukin signaling pathway	P00965	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00219	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	CHICK|Ensembl=ENSGALG00000027629|UniProtKB=Q5ZJ03	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00029	Huntington disease	P00777	CBP	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MOUSE|MGI=MGI=1928896|UniProtKB=Q9R0Q6	Actin-related protein 2/3 complex subunit 1A	ISS	12473693	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00005	Angiogenesis	P00206	Wnt	HUMAN|HGNC=13829|UniProtKB=Q9GZT5	Protein Wnt-10a	ISS	11266476	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P02734	Chorismate biosynthesis	P02874	Shikimate kinase	ARATH|TAIR=AT4G39540|UniProtKB=Q8GY88	Shikimate kinase 2, chloroplastic	ISS			PTHR21087:SF16	SHIKIMATE KINASE 1, CHLOROPLASTIC-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	XENTR|Xenbase=XB-GENE-6035431|UniProtKB=F6RJ06	Uncharacterized protein	ISS	11861492	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00034	Integrin signalling pathway	P00944	Actin	PANTR|Ensembl=ENSPTRG00000009762|UniProtKB=H2QE24	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00009	Axon guidance mediated by netrin	P00357	Netrin	MONDO|Ensembl=ENSMODG00000008479|UniProtKB=F7G4D6	Uncharacterized protein	ISS	11356879	PubMed	PTHR10574:SF365	NETRIN-1
P04397	p53 pathway by glucose deprivation	P04641	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00163	Erb-B4 C-terminal fragment	MACMU|Ensembl=ENSMMUG00000001674|UniProtKB=F7G3H1	Receptor protein-tyrosine kinase	ISS	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00018	EGF receptor signaling pathway	P00558	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	IDA	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PUCGT|EnsemblGenome=PGTG_05488|UniProtKB=E3K4I1	Actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	RAT|RGD=620761|UniProtKB=Q9R172	Neurogenic locus notch homolog protein 3	IDA	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00034	Integrin signalling pathway	P00920	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00045	Notch signaling pathway	P01116	Delta	HUMAN|HGNC=2910|UniProtKB=Q9NR61	Delta-like protein 4	ISS	11798067	PubMed	PTHR24044:SF320	DELTA-LIKE PROTEIN 4
P00005	Angiogenesis	P00212	EphR	MOUSE|MGI=MGI=1096337|UniProtKB=Q8CBF3	Ephrin type-B receptor 1	RCA			PTHR24416:SF173	EPHRIN TYPE-B RECEPTOR 1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IDA	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00012	Cadherin signaling pathway	P00474	Wnt	MACMU|Ensembl=ENSMMUG00000018445|UniProtKB=F7HEW6	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00833	RGS	MOUSE|MGI=MGI=1354694|UniProtKB=Q9JL25	Regulator of G-protein signaling 1	IDA	8756726	PubMed	PTHR10845:SF34	REGULATOR OF G-PROTEIN SIGNALING 1
P00010	B cell activation	P00402	Jnk	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00048	PI3 kinase pathway	P01177	P110ACT	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01160	IP3 receptor	CAEBR|Gene=CBG_05938|UniProtKB=H8WGV2	Protein CBR-ITR-1, isoform a	ISS	12880387	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00037	Ionotropic glutamate receptor pathway	P01018	Glu1	MONDO|Ensembl=ENSMODG00000008900|UniProtKB=F7B4C1	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P04393	Ras Pathway	P04542	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	G06894	c-fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	RCA	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00005	Angiogenesis	P00193	SOS-1	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00006	Apoptosis signaling pathway	P00302	ATF	MONDO|Ensembl=ENSMODG00000006900|UniProtKB=F6PUU3	Uncharacterized protein	ISS			PTHR22952:SF97	CAMP-RESPONSIVE ELEMENT MODULATOR
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00560	Raf-1	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS			PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02740	De novo pyrimidine ribonucleotides biosythesis	P02927	Dihydrooratate oxidase	MOUSE|MGI=MGI=1928378|UniProtKB=O35435	Dihydroorotate dehydrogenase (quinone), mitochondrial	ISS			PTHR43517:SF1	DIHYDROOROTATE DEHYDROGENASE  QUINONE , MITOCHONDRIAL
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	DROME|FlyBase=FBgn0019985|UniProtKB=P91685	Metabotropic glutamate receptor	IDA	9407094	PubMed	PTHR24060:SF137	METABOTROPIC GLUTAMATE RECEPTOR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05731	GABA-B receptor II signaling	P05754	Ggamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	RCA	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	HUMAN|HGNC=1712|UniProtKB=P32320	Cytidine deaminase	ISS	12844405	PubMed	PTHR11644:SF2	CYTIDINE DEAMINASE
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00586	Gq	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P06959	CCKR signaling map	G06982	MCL1	HUMAN|HGNC=6943|UniProtKB=Q07820	Induced myeloid leukemia cell differentiation protein Mcl-1	RCA	18719002	PubMed	PTHR11256:SF46	INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN MCL-1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	HUMAN|HGNC=20771|UniProtKB=P68371	Tubulin beta-4B chain	ISS	9454836	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P02729	Ascorbate degradation	P02849	L-xylulose kinase	YEAST|SGD=S000003426|UniProtKB=P42826	Xylulose kinase	ISS			PTHR10196:SF57	XYLULOSE KINASE
P00047	PDGF signaling pathway	P01160	IP3 receptor	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00010	B cell activation	P00402	Jnk	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00034	Integrin signalling pathway	P00934	VASP	RAT|RGD=1311542|UniProtKB=A0A0G2K9C0	Protein Vasp	ISS	8836115	PubMed	PTHR11202:SF12	VASODILATOR-STIMULATED PHOSPHOPROTEIN
P00012	Cadherin signaling pathway	P00471	Cadherin	CANLF|Ensembl=ENSCAFG00000000086|UniProtKB=F1PVD5	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF84	CADHERIN-20
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	PANTR|Gene=CXCR1|UniProtKB=P55920	C-X-C chemokine receptor type 1	ISS	4504683	gi	PTHR10489:SF916	C-X-C CHEMOKINE RECEPTOR TYPE 1
P05913	Enkephalin release	P05977	G-Protein (s)	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00036	Interleukin signaling pathway	P00977	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IC	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00052	TGF-beta signaling pathway	P01275	P38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	TAS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05915	Opioid proenkephalin pathway	P05994	G-protein	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00029	Huntington disease	P00790	beta-Tubulin	SCHMA|EnsemblGenome=Smp_030730|UniProtKB=G4LW34	Tubulin beta chain,putative	ISS	12932731	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00038	JAK/STAT signaling pathway	P01027	STAT	PANTR|Ensembl=ENSPTRG00000009199|UniProtKB=H2QD19	Signal transducer and activator of transcription	ISS	7514531	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IDA	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	RAT|RGD=620761|UniProtKB=Q9R172	Neurogenic locus notch homolog protein 3	IDA	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00019	Endothelin signaling pathway	P00589	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	IC	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DICDI|dictyBase=DDB_G0279413|UniProtKB=P05987	cAMP-dependent protein kinase regulatory subunit	IC	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00053	T cell activation	P01332	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IDA	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	CANLF|Ensembl=ENSCAFG00000017522|UniProtKB=Q076A4	Myosin-8	ISS	10938134	PubMed	PTHR13140:SF368	MYOSIN-8
P00034	Integrin signalling pathway	P00938	Cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00047	PDGF signaling pathway	P01159	SOS	DICDI|dictyBase=DDB_G0269252|UniProtKB=Q8IS18	Ras guanine nucleotide exchange factor E	ISS			PTHR23113:SF209	RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR E
P00029	Huntington disease	P00761	Truncated Htt	CANLF|Ensembl=ENSCAFG00000014682|UniProtKB=F1P7Y7	Uncharacterized protein	ISS	7620118	PubMed	PTHR10170:SF10	HUNTINGTIN
P00054	Toll receptor signaling pathway	P01358	ERK1	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05918	p38 MAPK pathway	P06023	MEF	MACMU|Ensembl=ENSMMUG00000018122|UniProtKB=F7FGA1	Uncharacterized protein	ISS	11274345	PubMed	PTHR11945:SF145	MYOCYTE-SPECIFIC ENHANCER FACTOR 2A
P00021	FGF signaling pathway	P00638	PLCgamma	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	BOVIN|Gene=ARPC5|UniProtKB=Q3SYX9	Actin-related protein 2/3 complex subunit 5	ISS	12473693	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6880|UniProtKB=Q13164	Mitogen-activated protein kinase 7	ISS	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	DROME|FlyBase=FBgn0004611|UniProtKB=P25455	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	RAT|RGD=2036|UniProtKB=P40146	Adenylate cyclase type 8	IDA	2491850	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00057	Wnt signaling pathway	P01451	Galpha	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IDA	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00034	Integrin signalling pathway	P00920	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00010	B cell activation	P00379	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00021	FGF signaling pathway	P00627	ERK1-2	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	IGI	10851062	PubMed	PTHR24055:SF330	SUBFAMILY NOT NAMED
P00060	Ubiquitin proteasome pathway	P01492	E1	SCHPO|PomBase=SPAC24H6.12c|UniProtKB=Q09765	NEDD8-activating enzyme E1 catalytic subunit	ISS			PTHR10953:SF6	NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	PANTR|Ensembl=ENSPTRG00000004718|UniProtKB=H2Q5I0	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00005	Angiogenesis	P00249	PAK	RAT|RGD=3250|UniProtKB=P35465	Serine/threonine-protein kinase PAK 1	ISS	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	ARATH|TAIR=AT1G13890|UniProtKB=Q9LMG8	Putative SNAP25 homologous protein SNAP30	ISS	10327594	PubMed	PTHR19305:SF7	SNAP25 HOMOLOGOUS PROTEIN SNAP30-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00078	Alpha1A/1B/1C	HUMAN|HGNC=278|UniProtKB=P35368	Alpha-1B adrenergic receptor	IC	6323229	PubMed	PTHR24248:SF17	ALPHA-1B ADRENERGIC RECEPTOR
P00006	Apoptosis signaling pathway	P00306	TRAF2	DROME|FlyBase=FBgn0265464|UniProtKB=Q9W3I9	GH01161p	ISS			PTHR10131:SF111	TNF RECEPTOR-ASSOCIATED FACTOR 6
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00004	Alzheimer disease-presenilin pathway	P00131	HAC1	MOUSE|MGI=MGI=1860040|UniProtKB=Q9R1R2	Tripartite motif-containing protein 3	IDA			PTHR44028:SF1	TRIPARTITE MOTIF-CONTAINING PROTEIN 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04557	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00795	BDNF	HUMAN|HGNC=1033|UniProtKB=P23560	Brain-derived neurotrophic factor	ISS	11408619	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00056	VEGF signaling pathway	P01423	p38MAPK	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00034	Integrin signalling pathway	P00951	Jnk	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	TAS	12471242	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00017	DNA replication	P00535	5' to 3' Exoribonulcease	ORNAN|Ensembl=ENSOANG00000015673|UniProtKB=F7EXN5	Uncharacterized protein	ISS	99339991	PubMed	PTHR12341:SF41	5'-3' EXORIBONUCLEASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	TAS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00046	Oxidative stress response	P01123	Bcl-2	MACMU|Ensembl=ENSMMUG00000006577|UniProtKB=F7HPT9	Uncharacterized protein	ISS	11323415	PubMed	PTHR11256:SF11	APOPTOSIS REGULATOR BCL-2
P00047	PDGF signaling pathway	P01174	Rho	CHICK|Ensembl=ENSGALG00000012421|UniProtKB=Q5ZMM3	Rho GTPase-activating protein 15	ISS	8288572	PubMed	PTHR23181:SF5	RHO GTPASE-ACTIVATING PROTEIN 15
P00011	Blood coagulation	P00433	uPAR	MACMU|Ensembl=ENSMMUG00000009906|UniProtKB=F6YDX7	Uncharacterized protein	ISS			PTHR24264:SF38	UROKINASE-TYPE PLASMINOGEN ACTIVATOR
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	TAKRU|Ensembl=ENSTRUG00000005608|UniProtKB=H2SM93	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P02738	De novo purine biosynthesis	P02900	AICAR transformylase	HALSA|EnsemblGenome=VNG_0414G|UniProtKB=Q9HS43	Phosphoribosylaminoimidazole-succinocarboxamide formyltransferase	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P00023	General transcription regulation	P00668	TFIIB	ARATH|TAIR=AT3G29380|UniProtKB=Q9LIA6	Plant-specific TFIIB-related protein 2	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MOUSE|MGI=MGI=2444552|UniProtKB=Q8BFZ3	Beta-actin-like protein 2	IDA	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P04393	Ras Pathway	P04558	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P06664	Gonadotropin-releasing hormone receptor pathway	P06798	PKCe/theta	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	RCA	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00108	ADAM10	MONDO|Ensembl=ENSMODG00000008735|UniProtKB=F6PTE7	Uncharacterized protein	ISS	10097139	PubMed	PTHR11905:SF4	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 10
P00003	Alzheimer disease-amyloid secretase pathway	P00094	BACE-1 pro-domain	HUMAN|HGNC=934|UniProtKB=Q9Y5Z0	Beta-secretase 2	IDA			PTHR13683:SF262	BETA-SECRETASE 2
P00034	Integrin signalling pathway	P00911	B-Raf	MOUSE|MGI=MGI=88190|UniProtKB=P28028	Serine/threonine-protein kinase B-raf	IDA	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00636	FGFR1-4	MONDO|Ensembl=ENSMODG00000008525|UniProtKB=F7DHF8	Fibroblast growth factor receptor	ISS	8089146	PubMed	PTHR24416:SF130	FIBROBLAST GROWTH FACTOR RECEPTOR 2
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-010705-1|UniProtKB=Q90Z40	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00049	Parkinson disease	P01236	Casein kinase II	CAEEL|WormBase=WBGene00002196|UniProtKB=P28548	Casein kinase II subunit beta	IDA	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00628	JNK1-3	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IGI	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	3035212	PubMed	PTHR24070:SF385	GTPASE HRAS
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DANRE|ZFIN=ZDB-GENE-041001-104|UniProtKB=Q5TZD4	Protein kinase C	ISS	11880265	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IDA	2372396	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00030	Hypoxia response via HIF activation	P00824	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	TAS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01136	Elk-1	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	10487205	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00004	Alzheimer disease-presenilin pathway	P00178	BACE-1 pro-domain	MONDO|Ensembl=ENSMODG00000013692|UniProtKB=F6QP52	Uncharacterized protein	ISS	10956649	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00047	PDGF signaling pathway	P01155	Jak	HUMAN|HGNC=6192|UniProtKB=O60674	Tyrosine-protein kinase JAK2	ISS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00048	PI3 kinase pathway	P01185	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	10644715	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	RAT|RGD=3238|UniProtKB=P01179	Oxytocin-neurophysin 1	ISS	192340	OMIM	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	CANLF|Ensembl=ENSCAFG00000015662|UniProtKB=E2RHY4	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MOUSE|MGI=MGI=102522|UniProtKB=Q8R3Z5	Voltage-dependent L-type calcium channel subunit beta-1	IC	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	3136397	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	BACSU|EnsemblGenome=BSU19310|UniProtKB=O34660	Putative aldehyde dehydrogenase DhaS	IC			PTHR11699:SF211	ALDEHYDE DEHYDROGENASE 5, MITOCHONDRIAL
P00045	Notch signaling pathway	P01099	Notch	RAT|RGD=3188|UniProtKB=Q9QW30	Neurogenic locus notch homolog protein 2	IEP	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00047	PDGF signaling pathway	P01145	c-fos	MACMU|Ensembl=ENSMMUG00000000033|UniProtKB=F7G4D2	Uncharacterized protein	ISS			PTHR11945:SF221	SERUM RESPONSE FACTOR
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	PANTR|Ensembl=ENSPTRG00000029908|UniProtKB=H2R050	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF90	FRIZZLED-8
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	ORNAN|Ensembl=ENSOANG00000004058|UniProtKB=F6TYP9	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00006	Apoptosis signaling pathway	P00269	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00786	ARF	XENTR|Xenbase=XB-GENE-961332|UniProtKB=Q5BJ82	ADP-ribosylation factor-like 1	ISS	11752622	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00018	EGF receptor signaling pathway	P00558	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	IGI	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05730	Endogenous cannabinoid signaling	P05746	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00047	PDGF signaling pathway	P01159	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000025373|UniProtKB=F6ZZG9	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00012	Cadherin signaling pathway	P00470	F-actin	TRIAD|EnsemblGenome=TriadG49626|UniProtKB=B3RKR4	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	XENTR|Xenbase=XB-GENE-491938|UniProtKB=Q6DIV8	Actin, alpha 1, skeletal muscle	ISS	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04393	Ras Pathway	P04572	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PLAF7|EnsemblGenome=PF11_0147|UniProtKB=Q7KQK7	Mitogen-activated protein kinase	IGI	10514528	PubMed	PTHR24055:SF189	SUBFAMILY NOT NAMED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00010	B cell activation	P00375	Calmodulin	MONDO|Ensembl=ENSMODG00000002696|UniProtKB=F7CY56	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF335	CALMODULIN, STRIATED MUSCLE
P00012	Cadherin signaling pathway	P00466	EGFR	ORNAN|Ensembl=ENSOANG00000007021|UniProtKB=F7GAV2	Receptor protein-tyrosine kinase	ISS	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00053	T cell activation	P01311	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01159	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00047	PDGF signaling pathway	P01154	Ras	DICPU|Gene=DICPUDRAFT_47179|UniProtKB=F0ZI47	Putative uncharacterized protein rasB	ISS	7997267	PubMed	PTHR24070:SF206	RAS-LIKE PROTEIN RASB
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=1922542|UniProtKB=Q8K1Y2	Serine/threonine-protein kinase D3	ISS	12676944	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P00019	Endothelin signaling pathway	P00590	IP3 R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IGI	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00005	Angiogenesis	P00219	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00013	Cell cycle	P00480	Proteasome	HUMAN|HGNC=9558|UniProtKB=Q9UNM6	26S proteasome non-ATPase regulatory subunit 13	ISS	10225435	PubMed	PTHR10539:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13
P00047	PDGF signaling pathway	P01145	c-fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05916	Opioid prodynorphin pathway	P06000	vasopressin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00049	Parkinson disease	P01219	SAPK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	NAS	10514528	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00627	ERK1-2	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CANLF|Ensembl=ENSCAFG00000024807|UniProtKB=F6XNB0	Uncharacterized protein	ISS	95224005	PubMed	PTHR18945:SF60	ACETYLCHOLINE RECEPTOR SUBUNIT GAMMA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CHICK|Ensembl=ENSGALG00000006576|UniProtKB=E1BUE5	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00005	Angiogenesis	P00203	Erk	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	MACMU|Ensembl=ENSMMUG00000000893|UniProtKB=F6T7D0	Histone acetyltransferase p300	ISS	10823891	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	IDA	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00516	Ena/VASP	RAT|RGD=1311542|UniProtKB=A0A0G2K9C0	Protein Vasp	ISS	8836115	PubMed	PTHR11202:SF12	VASODILATOR-STIMULATED PHOSPHOPROTEIN
P00018	EGF receptor signaling pathway	P00560	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00806	TAFII130	CAEEL|WormBase=WBGene00006385|UniProtKB=O61707	TAF (TBP-associated transcription factor) family	IDA	10973244	PubMed	PTHR15138:SF14	IP01149P-RELATED
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CAEEL|WormBase=WBGene00003774|UniProtKB=G5EGQ9	NMDA class glutamate Receptor	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00010	B cell activation	P00380	fos	RAT|RGD=2626|UniProtKB=P12841	Proto-oncogene c-Fos	TAS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P02752	Mannose metabolism	P03018	Mannose 1-P guanylyl transferase	LEIMA|EnsemblGenome=LmjF.23.0110|UniProtKB=Q4QBG5	Mannose-1-phosphate guanyltransferase	IEA	9477341	PubMed	PTHR22572:SF15	MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE BETA
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	ARATH|TAIR=AT3G02160|UniProtKB=Q9S7R9	At3g02160	ISS	604905	OMIM	PTHR12321:SF53	BROMODOMAIN TRANSCRIPTION FACTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	DROME|FlyBase=FBgn0003416|UniProtKB=Q9VXH3	Phosphoinositide phospholipase C	TAS			PTHR10336:SF91	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00036	Interleukin signaling pathway	P00996	STAT	PANTR|Ensembl=ENSPTRG00000005121|UniProtKB=H2Q6A5	Uncharacterized protein	ISS	8085155	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00029	Huntington disease	P00778	NMDA receptor	CANLF|Ensembl=ENSCAFG00000002617|UniProtKB=E2QUL1	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	DANRE|ZFIN=ZDB-GENE-041114-26|UniProtKB=F1RE11	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P02788	Xanthine and guanine salvage pathway	P03249	Guanine deaminase	DEIRA|EnsemblGenome=DR_A0180|UniProtKB=Q9RYX4	Probable guanine deaminase	ISS			PTHR11271:SF6	GUANINE DEAMINASE
P04397	p53 pathway by glucose deprivation	P04640	p53	CHICK|Ensembl=ENSGALG00000007324|UniProtKB=F1N8Z7	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00018	EGF receptor signaling pathway	P00561	STAT	MONDO|Ensembl=ENSMODG00000014816|UniProtKB=F7CHH2	Signal transducer and activator of transcription	ISS	14662325	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02762	Pentose phosphate pathway	P03079	Hexokinase	RAT|RGD=2797|UniProtKB=P27881	Hexokinase-2	RCA			PTHR19443:SF4	HEXOKINASE-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	MACMU|Ensembl=ENSMMUG00000021843|UniProtKB=F6RNI3	Uncharacterized protein	ISS	12787506	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00037	Ionotropic glutamate receptor pathway	P01026	KA	BOVIN|Ensembl=ENSBTAG00000034854|UniProtKB=F1N246	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	RAT|RGD=1562253|UniProtKB=D4A3K6	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P00017	DNA replication	P00536	DNA Topisomerase	ORNAN|Ensembl=ENSOANG00000012235|UniProtKB=F7FGH6	DNA topoisomerase 2	ISS			PTHR10169:SF36	DNA TOPOISOMERASE 2-BETA
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	RAT|RGD=2522|UniProtKB=P30729	D(4) dopamine receptor	ISS	1319557	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	CAEEL|WormBase=WBGene00001623|UniProtKB=O18210	Amino acid transporter	ISS			PTHR11958:SF45	AMINO ACID TRANSPORTER
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IDA	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00056	VEGF signaling pathway	P01425	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00006	Apoptosis signaling pathway	P00260	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	PANTR|Ensembl=ENSPTRG00000005006|UniProtKB=H2Q615	Integrin beta	ISS	3487386	PubMed	PTHR10082:SF36	INTEGRIN BETA-7
P00047	PDGF signaling pathway	P01168	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	ISS	96009592	PubMed	PTHR10048:SF14	PI-3 KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00053	T cell activation	P01311	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	PANTR|Ensembl=ENSPTRG00000011049|UniProtKB=H2QGF9	Glycogen synthase kinase 3 alpha	ISS	183955	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00029	Huntington disease	P00790	beta-Tubulin	PHYPA|Gene=PHYPADRAFT_213086|UniProtKB=A9SJR1	Beta-tubulin 4	ISS	12932731	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MONDO|Ensembl=ENSMODG00000001273|UniProtKB=F7CIF4	Uncharacterized protein	ISS			PTHR13140:SF438	SUBFAMILY NOT NAMED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00011	Blood coagulation	P00423	APC	RAT|RGD=3411|UniProtKB=P31394	Vitamin K-dependent protein C	ISS	6981412	gi	PTHR24278:SF0	VITAMIN K-DEPENDENT PROTEIN C
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00006	Apoptosis signaling pathway	P00318	PKCs	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	89186920	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	DANRE|Ensembl=ENSDARG00000071640|UniProtKB=E7F359	Uncharacterized protein	ISS			PTHR43893:SF9	SUBFAMILY NOT NAMED
P05915	Opioid proenkephalin pathway	P05989	leu-Enkephalin	RAT|RGD=68946|UniProtKB=P04094	Proenkephalin-A	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	ANOGA|Gene=AgaP_AGAP009443|UniProtKB=Q5TXC3	AGAP009443-PA (Fragment)	ISS	96032356	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P00005	Angiogenesis	P00234	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8235613	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00018	EGF receptor signaling pathway	P00543	ERK1-2	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IGI	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	YEAST|SGD=S000003870|UniProtKB=P03965	Carbamoyl-phosphate synthase arginine-specific large chain	ISS			PTHR11405:SF48	CARBAMOYL-PHOSPHATE SYNTHASE ARGININE-SPECIFIC LARGE CHAIN
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PHYPA|Gene=PHYPADRAFT_107830|UniProtKB=A9TBG2	Actin 7	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05915	Opioid proenkephalin pathway	P05994	G-protein	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DROME|FlyBase=FBgn0015765|UniProtKB=O62618	Mitogen-activated protein kinase 14A	TAS			PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00046	Oxidative stress response	P01121	MKK3/6	MACMU|Ensembl=ENSMMUG00000010904|UniProtKB=F7GLY5	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00049	Parkinson disease	P01242	Casein kinase I	ARATH|TAIR=AT5G57015|UniProtKB=Q8VYK9	Casein kinase 1-like protein 12	IDA	10617630	PubMed	PTHR11909:SF298	CASEIN KINASE 1-LIKE PROTEIN 12-RELATED
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000002775|UniProtKB=H2RB55	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=14257|UniProtKB=Q8N6Y1	Protocadherin-20	IDA	8120095	PubMed	PTHR43912:SF7	PROTOCADHERIN-20
P04398	p53 pathway feedback loops 2	P04665	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	G01544	GADD45	HUMAN|HGNC=4095|UniProtKB=P24522	Growth arrest and DNA damage-inducible protein GADD45 alpha	ISS	9827804	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CHICK|Ensembl=ENSGALG00000014539|UniProtKB=F1N861	Uncharacterized protein	ISS	1321498	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00790	beta-Tubulin	DAPPU|EnsemblGenome=DAPPUDRAFT_305638|UniProtKB=E9FWY0	Putative uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF252	BETA-TUBULIN AT 97EF, ISOFORM B
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	RAT|RGD=2739|UniProtKB=Q00961	Glutamate receptor ionotropic, NMDA 2C	IC	11554549	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	TAKRU|Ensembl=ENSTRUG00000000304|UniProtKB=H2RKM1	Uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MACMU|Ensembl=ENSMMUG00000014754|UniProtKB=F7G124	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF721	MYOSIN-6
P04397	p53 pathway by glucose deprivation	P04639	AMPK	MACMU|Ensembl=ENSMMUG00000015713|UniProtKB=F6SF90	Uncharacterized protein	ISS			PTHR13780:SF38	5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1
P00024	Glycolysis	P00680	Phosphoglyceromutase	MONDO|Ensembl=ENSMODG00000014127|UniProtKB=F6XLJ9	Uncharacterized protein	ISS	87055234	PubMed	PTHR11931:SF11	BISPHOSPHOGLYCERATE MUTASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	HUMAN|HGNC=15963|UniProtKB=Q15825	Neuronal acetylcholine receptor subunit alpha-6	ISS	15155845	PubMed	PTHR18945:SF82	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-6
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	TAS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00647	SHP2	PANTR|Ensembl=ENSPTRG00000042397|UniProtKB=H2RIH8	Tyrosine-protein phosphatase non-receptor type	ISS	1382983	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00038	JAK/STAT signaling pathway	P01027	STAT	PANTR|Ensembl=ENSPTRG00000009199|UniProtKB=H2QD19	Signal transducer and activator of transcription	ISS	8732682	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00036	Interleukin signaling pathway	P00981	SOS	CHICK|Ensembl=ENSGALG00000013224|UniProtKB=F1NMA4	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CRYNJ|EnsemblGenome=CNA04650|UniProtKB=Q5KP06	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00048	PI3 kinase pathway	P01182	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00004	Alzheimer disease-presenilin pathway	P00160	Nectin 1alpha	RAT|RGD=620791|UniProtKB=F1LNP8	Poliovirus receptor-related 1	ISS	12376527	PubMed	PTHR23277:SF69	NECTIN-1
P00021	FGF signaling pathway	P00638	PLCgamma	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CAEBR|Gene=CBG17587|UniProtKB=A8XRA5	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00051	TCA cycle	P01267	Citrate Synthase	ECOLI|EcoGene=EG10402|UniProtKB=P0ABH7	Citrate synthase	ISS	15800424	gi	PTHR42871:SF1	CITRATE SYNTHASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ARATH|TAIR=AT3G18780|UniProtKB=Q96292	Actin-2	ISS	10974003	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00021	FGF signaling pathway	P00645	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00047	PDGF signaling pathway	P01175	Shc	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	ISS	95096035	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00018	EGF receptor signaling pathway	P00552	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05915	Opioid proenkephalin pathway	P05995	proenkephalin	PANTR|Ensembl=ENSPTRG00000020270|UniProtKB=H2QW70	Proenkephalin	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00019	Endothelin signaling pathway	P00586	Gq	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05918	p38 MAPK pathway	P06043	ASK1	PANTR|Ensembl=ENSPTRG00000024326|UniProtKB=H2R231	Uncharacterized protein	ISS	12697749	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MACMU|Ensembl=ENSMMUG00000012164|UniProtKB=F7GW57	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	SCLS1|EnsemblGenome=SS1G_03482|UniProtKB=A7EDU2	Guanine nucleotide-binding protein beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00012	Cadherin signaling pathway	P00465	TCF/LEF	HUMAN|HGNC=6551|UniProtKB=Q9UJU2	Lymphoid enhancer-binding factor 1	ISS	11266476	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00006	Apoptosis signaling pathway	P00302	ATF	MOUSE|MGI=MGI=109349|UniProtKB=P16951	Cyclic AMP-dependent transcription factor ATF-2	ISS	10207617	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00045	Notch signaling pathway	P01099	Notch	BOVIN|Ensembl=ENSBTAG00000043971|UniProtKB=E1BPT8	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01444	Wnt	CANLF|Ensembl=ENSCAFG00000014987|UniProtKB=E2RH98	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	PANTR|Ensembl=ENSPTRG00000012660|UniProtKB=H2QJ07	Activating transcription factor 2	ISS	7875593	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P05731	GABA-B receptor II signaling	P05755	Gbeta	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P05918	p38 MAPK pathway	P06021	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	20264070	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014262|UniProtKB=F7BYS8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MONDO|Ensembl=ENSMODG00000006594|UniProtKB=F7AKA6	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	RAT|RGD=61863|UniProtKB=P19493	Glutamate receptor 4	ISS	12871085	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CHICK|Gene=CHRM4|UniProtKB=P17200	Muscarinic acetylcholine receptor M4	IDA	12181435	PubMed	PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00049	Parkinson disease	P01241	TH	MACMU|Ensembl=ENSMMUG00000003912|UniProtKB=F6ZV38	Uncharacterized protein	ISS	12480184	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04564	MAPKAP	BOVIN|Ensembl=ENSBTAG00000038107|UniProtKB=F1MCX5	Uncharacterized protein	ISS	9628873	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00029	Huntington disease	P00763	Hip-12	RAT|RGD=1305947|UniProtKB=D4A1V1	Intraflagellar transport 57 homolog (Chlamydomonas) (Predicted)	ISS			PTHR16011:SF0	INTRAFLAGELLAR TRANSPORT PROTEIN 57 HOMOLOG
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05916	Opioid prodynorphin pathway	P06002	G-protein	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00029	Huntington disease	P00790	beta-Tubulin	PHYPA|Gene=PHYPADRAFT_165677|UniProtKB=Q6TYR3	Beta-tubulin 5	ISS	9454836	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	TAS	3045562	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00053	T cell activation	P01336	Jnk	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02738	De novo purine biosynthesis	P02909	GDP reductase	NEUCR|EnsemblGenome=EFNCRG00000007504|UniProtKB=Q9C167	Ribonucleoside-diphosphate reductase small chain	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00019	Endothelin signaling pathway	P00568	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06722	PITX	MOUSE|MGI=MGI=107374|UniProtKB=P70314	Pituitary homeobox 1	RCA			PTHR24329:SF263	PITUITARY HOMEOBOX 1
P00047	PDGF signaling pathway	P01150	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00539	14-3-3	ARATH|TAIR=AT1G78220|UniProtKB=F4IA59	General regulatory factor 13	ISS			PTHR18860:SF32	14-3-3 FAMILY PROTEIN-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=619858|UniProtKB=P70579	Metabotropic glutamate receptor 8	IDA	12488551	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00059	p53 pathway	G01571	FAS	MOUSE|MGI=MGI=95484|UniProtKB=P25446	Tumor necrosis factor receptor superfamily member 6	IGI	10327065	PubMed	PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	CHLRE|EnsemblGenome=CHLREDRAFT_15736|UniProtKB=Q8W1K7	Serine/threonine protein kinase	IDA	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05753	Ca channel	RAT|RGD=628852|UniProtKB=Q02294	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	14624853	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000011761|UniProtKB=F1MDE1	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00006	Apoptosis signaling pathway	P00318	PKCs	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00018	EGF receptor signaling pathway	P00557	PI3K	CANAL|CGD=CAL0068551|UniProtKB=Q5AAR9	Phosphatidylinositol 3-kinase	IGI	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00036	Interleukin signaling pathway	P00990	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00011	Blood coagulation	P00408	Plasminogen	PANTR|Ensembl=ENSPTRG00000018774|UniProtKB=H2QU06	Plasminogen	ISS	4505881	gi	PTHR24261:SF6	PLASMINOGEN
P00037	Ionotropic glutamate receptor pathway	P01026	KA	BOVIN|Ensembl=ENSBTAG00000009269|UniProtKB=F1MCM2	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00023	General transcription regulation	P00663	TFIIFalpha	MOUSE|MGI=MGI=1923848|UniProtKB=Q3THK3	General transcription factor IIF subunit 1	ISS	12732728	PubMed	PTHR13011:SF0	GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06807	gnai	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00029	Huntington disease	P00786	ARF	MONDO|Ensembl=ENSMODG00000024451|UniProtKB=F6Z8M9	Uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF234	ADP-RIBOSYLATION FACTOR 1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00927	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	20010089	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04398	p53 pathway feedback loops 2	G04714	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01457	GBeta	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	BACSU|EnsemblGenome=BSU15510|UniProtKB=P25993	Carbamoyl-phosphate synthase pyrimidine-specific small chain	ISS			PTHR11405:SF4	CARBAMOYL-PHOSPHATE SYNTHASE ARGININE-SPECIFIC SMALL CHAIN
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IGI	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P02738	De novo purine biosynthesis	P02899	GMP synthase	BACSU|EnsemblGenome=BSU06360|UniProtKB=P29727	GMP synthase [glutamine-hydrolyzing]	ISS			PTHR11922:SF2	GMP SYNTHASE  GLUTAMINE-HYDROLYZING
P06664	Gonadotropin-releasing hormone receptor pathway	G06885	Follistatin	MOUSE|MGI=MGI=95586|UniProtKB=P47931	Follistatin	RCA			PTHR10913:SF6	FOLLISTATIN
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	STRPU|Gene=CYIIIA|UniProtKB=P53474	Actin, cytoskeletal 3A	ISS	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	LEIMA|EnsemblGenome=LmjF.25.1120|UniProtKB=Q4Q9Y1	Aldehyde dehydrogenase, mitochondrial	ISS			PTHR11699:SF211	ALDEHYDE DEHYDROGENASE 5, MITOCHONDRIAL
P00034	Integrin signalling pathway	P00906	Rap1	XENTR|Xenbase=XB-GENE-493696|UniProtKB=Q28G68	RAP2B, member of RAS oncogene family	ISS	8576107	PubMed	PTHR24070:SF194	RAS-RELATED PROTEIN RAP-2B
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	USTMA|Gene=UMAG_11232|UniProtKB=A0A0D1DMT3	Chromosome 22, whole genome shotgun sequence	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00019	Endothelin signaling pathway	P00589	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DANRE|ZFIN=ZDB-GENE-000330-4|UniProtKB=Q1MTI1	Uncharacterized protein	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P05731	GABA-B receptor II signaling	P05753	Ca channel	MOUSE|MGI=MGI=109482|UniProtKB=P97445	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	14507926	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00012	Cadherin signaling pathway	P00475	Frizzled	HUMAN|HGNC=4043|UniProtKB=Q13467	Frizzled-5	IDA	8717036	PubMed	PTHR11309:SF126	FRIZZLED-5
P00018	EGF receptor signaling pathway	P00543	ERK1-2	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	IGI	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IDA	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00015	Circadian clock system	G01497	cry	CANLF|Ensembl=ENSCAFG00000009379|UniProtKB=F1PNC9	Uncharacterized protein	ISS	11533252	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P05915	Opioid proenkephalin pathway	P05994	G-protein	BOVIN|Ensembl=ENSBTAG00000003762|UniProtKB=A5PJS1	GNB5 protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00047	PDGF signaling pathway	P01162	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00035	Interferon-gamma signaling pathway	P00958	PIAS	HUMAN|HGNC=17311|UniProtKB=O75928	E3 SUMO-protein ligase PIAS2	TAS	8682149	PubMed	PTHR10782:SF12	E3 SUMO-PROTEIN LIGASE PIAS2
P00018	EGF receptor signaling pathway	P00562	p38	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	IGI	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00006	Apoptosis signaling pathway	P00318	PKCs	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	MOUSE|MGI=MGI=1298218|UniProtKB=O88572	Low-density lipoprotein receptor-related protein 6	IDA	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00003	Alzheimer disease-amyloid secretase pathway	P00095	Nicastrin	MACMU|Ensembl=ENSMMUG00000021856|UniProtKB=F7EHX8	Nicastrin	ISS	16096062	PubMed	PTHR21092:SF0	NICASTRIN
P00034	Integrin signalling pathway	P00948	Rho	HUMAN|HGNC=669|UniProtKB=P08134	Rho-related GTP-binding protein RhoC	ISS	14871999	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	MOUSE|MGI=MGI=1916603|UniProtKB=Q9D2A5	Cyclic AMP-responsive element-binding protein 3-like protein 4	RCA			PTHR22952:SF105	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	HUMAN|HGNC=10611|UniProtKB=Q99616	C-C motif chemokine 13	ISS			PTHR12015:SF147	C-C MOTIF CHEMOKINE 13
P00019	Endothelin signaling pathway	P00568	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00012	Cadherin signaling pathway	P00474	Wnt	CANLF|Ensembl=ENSCAFG00000032632|UniProtKB=J9P2Q5	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P04393	Ras Pathway	P04557	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IDA	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00007	Axon guidance mediated by semaphorins	P00331	PAK	CANLF|Ensembl=ENSCAFG00000004956|UniProtKB=E2REH3	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00009	Axon guidance mediated by netrin	P00366	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	8649368	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	15621031	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00019	Endothelin signaling pathway	P00572	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	IGI	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00029	Huntington disease	P00807	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g188243|UniProtKB=A7SCN8	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00049	Parkinson disease	P01242	Casein kinase I	ARATH|TAIR=AT3G03940|UniProtKB=Q9SQR8	Protein kinase family protein	IDA	11437445	PubMed	PTHR11909:SF131	CASEIN KINASE-LIKE PROTEIN-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04398	p53 pathway feedback loops 2	P04665	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00996	STAT	HUMAN|HGNC=11366|UniProtKB=P42229	Signal transducer and activator of transcription 5A	IC	96210005	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00048	PI3 kinase pathway	P01199	Galpha	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05915	Opioid proenkephalin pathway	P05994	G-protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=4598|UniProtKB=O15303	Metabotropic glutamate receptor 6	IDA	11431030	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00054	Toll receptor signaling pathway	P01375	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00243	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	TAKRU|Ensembl=ENSTRUG00000016101|UniProtKB=H2UW32	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	MOUSE|MGI=MGI=104781|UniProtKB=P48542	G protein-activated inward rectifier potassium channel 2	IDA	12374786	PubMed	PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000011078|UniProtKB=F7FX79	Protocadherin-19 isoform c	ISS	8120095	PubMed	PTHR24028:SF40	PROTOCADHERIN-19
P00048	PI3 kinase pathway	P01182	Ras	DICDI|dictyBase=DDB_G0292996|UniProtKB=P03967	Ras-like protein rasD	ISS	85024887	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00019	Endothelin signaling pathway	P00586	Gq	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00059	p53 pathway	G04694	p110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00371	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	MOUSE|MGI=MGI=1916998|UniProtKB=Q571I9	Aldehyde dehydrogenase family 16 member A1	IC			PTHR11699:SF98	ALDEHYDE DEHYDROGENASE FAMILY 16 MEMBER A1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	PANTR|Ensembl=ENSPTRG00000000843|UniProtKB=H2QZN8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00006	Apoptosis signaling pathway	P00303	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00007	Axon guidance mediated by semaphorins	P00340	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	20010089	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00052	TGF-beta signaling pathway	P01286	TGFbeta	HUMAN|HGNC=6066|UniProtKB=P08476	Inhibin beta A chain	TAS	9395284	PubMed	PTHR11848:SF133	INHIBIN BETA A CHAIN
P00006	Apoptosis signaling pathway	P00322	Cytochrome C	DICDI|dictyBase=DDB_G0275537|UniProtKB=Q869N1	Cytochrome c	ISS			PTHR11961:SF12	CYTOCHROME C
P00046	Oxidative stress response	P01134	cPLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	TAS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	MOUSE|MGI=MGI=98848|UniProtKB=P12656	Thyrotropin subunit beta	ISS	5101174	PubMed	PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS			PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00012	Cadherin signaling pathway	P00470	F-actin	PHYPA|Gene=PHYPADRAFT_109052|UniProtKB=A9TZ58	Actin 5	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00007	Axon guidance mediated by semaphorins	P00341	Rho	XENTR|Xenbase=XB-GENE-489222|UniProtKB=Q28GJ8	Ras homolog gene family, member A	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00790	beta-Tubulin	BOVIN|Gene=TUBB6|UniProtKB=Q2HJ81	Tubulin beta-6 chain	ISS	12932731	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	IDA	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00562	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IGI	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05731	GABA-B receptor II signaling	P05753	Ca channel	HUMAN|HGNC=1394|UniProtKB=O43497	Voltage-dependent T-type calcium channel subunit alpha-1G	TAS	18021322	PubMed	PTHR10037:SF137	VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1G
P02741	Flavin biosynthesis	P02935	GTP cyclohydrolase	BACSU|EnsemblGenome=BSU23260|UniProtKB=P17620	Riboflavin biosynthesis protein RibBA	ISS			PTHR21327:SF32	SUBFAMILY NOT NAMED
P00010	B cell activation	P00373	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	HUMAN|HGNC=1030|UniProtKB=P30411	B2 bradykinin receptor	IDA	12130679	PubMed	PTHR24228:SF25	B2 BRADYKININ RECEPTOR
P02748	Isoleucine biosynthesis	P02998	Dihydroxyacid dehydratase	YEAST|SGD=S000003777|UniProtKB=P39522	Dihydroxy-acid dehydratase, mitochondrial	ISS			PTHR21000:SF5	DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	XENTR|Xenbase=XB-GENE-1002222|UniProtKB=F6YTJ1	Uncharacterized protein	ISS			PTHR13140:SF317	MYOSIN-9
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02916	dTMP kinase	MOUSE|MGI=MGI=108396|UniProtKB=P97930	Thymidylate kinase	ISS			PTHR10344:SF1	THYMIDYLATE KINASE
P05915	Opioid proenkephalin pathway	P05993	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IDA	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00011	Blood coagulation	P00413	HMWK	MOUSE|MGI=MGI=1097705|UniProtKB=O08677	Kininogen-1	ISS	12643495	gi	PTHR13814:SF12	KININOGEN-1
P00053	T cell activation	P01320	PLC-gamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00034	Integrin signalling pathway	P00936	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IPI	12660731	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01413	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01305	Calmodulin	CANLF|Ensembl=ENSCAFG00000030049|UniProtKB=J9NWQ5	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF311	CALMODULIN
P00018	EGF receptor signaling pathway	P00546	GAP	CHICK|Ensembl=ENSGALG00000004323|UniProtKB=F1NW82	Uncharacterized protein	ISS	9877179	PubMed	PTHR10194:SF52	RAS GTPASE-ACTIVATING PROTEIN NGAP
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	IDA	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	TAS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00006	Apoptosis signaling pathway	P00269	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00045	Notch signaling pathway	P01120	NIcs	MOUSE|MGI=MGI=99460|UniProtKB=Q61982	Neurogenic locus notch homolog protein 3	IC	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P04374	5HT2 type receptor mediated signaling pathway	P04413	K+ channel	MONDO|Ensembl=ENSMODG00000015769|UniProtKB=F6ZSC2	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	7492337	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	BOVIN|Ensembl=ENSBTAG00000014470|UniProtKB=E1BMG9	10-formyltetrahydrofolate dehydrogenase	ISS			PTHR11699:SF120	CYTOSOLIC 10-FORMYLTETRAHYDROFOLATE DEHYDROGENASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CAEBR|Gene=CBG17587|UniProtKB=A8XRA5	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00053	T cell activation	P01336	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	MOUSE|MGI=MGI=104756|UniProtKB=B8JK39	Integrin alpha-9	IDA	3487386	PubMed	PTHR23220:SF69	INTEGRIN ALPHA-9
P00010	B cell activation	P00398	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05754	Ggamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00021	FGF signaling pathway	P00632	Akt	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	IGI	22081553	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00833	RGS	RAT|RGD=620003|UniProtKB=O08773	Regulator of G-protein signaling 14	ISS	10779778	PubMed	PTHR10845:SF179	REGULATOR OF G-PROTEIN SIGNALING 14
P00057	Wnt signaling pathway	P01464	Pygo	MONDO|Ensembl=ENSMODG00000017142|UniProtKB=F6TM66	Uncharacterized protein	ISS	11955446	PubMed	PTHR23194:SF7	PYGOPUS HOMOLOG 2
P00034	Integrin signalling pathway	P00941	Integrin alpha	HUMAN|HGNC=6148|UniProtKB=P20701	Integrin alpha-L	IPI	11163192	PubMed	PTHR23220:SF84	INTEGRIN ALPHA-L
P04393	Ras Pathway	P04559	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00019	Endothelin signaling pathway	P00587	Raf-1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P05915	Opioid proenkephalin pathway	P05994	G-protein	MACMU|Ensembl=ENSMMUG00000014807|UniProtKB=F6W548	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00007	Axon guidance mediated by semaphorins	P00340	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00047	PDGF signaling pathway	P01161	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Ensembl=ENSPTRG00000018449|UniProtKB=H2QTG5	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	CHICK|Gene=PSEN2|UniProtKB=Q90X07	Presenilin-2	IDA	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00049	Parkinson disease	P01219	SAPK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01458	Protein Kinase C	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00034	Integrin signalling pathway	P00921	PINCH	MOUSE|MGI=MGI=1195263|UniProtKB=Q99JW4	LIM and senescent cell antigen-like-containing domain protein 1	IPI	10022929	PubMed	PTHR24210:SF11	LIM AND SENESCENT CELL ANTIGEN-LIKE-CONTAINING DOMAIN PROTEIN 1-RELATED
P00054	Toll receptor signaling pathway	P01357	MEKK1	BOVIN|Ensembl=ENSBTAG00000013790|UniProtKB=E1B847	Uncharacterized protein	ISS	8940199	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	HUMAN|HGNC=1736|UniProtKB=P60953	Cell division control protein 42 homolog	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00019	Endothelin signaling pathway	P00586	Gq	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00057	Wnt signaling pathway	P01430	p53	BOVIN|Ensembl=ENSBTAG00000001069|UniProtKB=P67939	Cellular tumor antigen p53	IDA	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IGI	7937853	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00017	DNA replication	P00535	5' to 3' Exoribonulcease	ORYSJ|EnsemblGenome=OS01G0872700|UniProtKB=Q5N739	Os01g0872700 protein	NAS	19571126	gi	PTHR12341:SF30	5'-3' EXORIBONUCLEASE 2-RELATED
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00371	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01336	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IGI	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00009	Axon guidance mediated by netrin	P00363	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P02723	Adenine and hypoxanthine salvage pathway	P02809	Xanthine dehydrogenase	MACMU|Ensembl=ENSMMUG00000000561|UniProtKB=F6Y3F0	Uncharacterized protein	ISS	8708081	PubMed	PTHR11908:SF80	XANTHINE DEHYDROGENASE/OXIDASE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MOUSE|MGI=MGI=1933206|UniProtKB=A2AIR5	Protein Grin3a	ISS	14698601	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P05913	Enkephalin release	P05977	G-Protein (s)	CHICK|Ensembl=ENSGALG00000007509|UniProtKB=F1NM72	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00056	VEGF signaling pathway	P01413	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01208	Hsp70	HUMAN|HGNC=5244|UniProtKB=P38646	Stress-70 protein, mitochondrial	IDA	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IC	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00049	Parkinson disease	P01211	ERK	MACMU|Ensembl=ENSMMUG00000001187|UniProtKB=F6R8N9	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DROME|FlyBase=FBgn0001122|UniProtKB=P16378	G protein alpha o subunit	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IPI	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01451	Galpha	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00846	JAK	RAT|RGD=2320469|UniProtKB=D3ZD03	Tyrosine-protein kinase	ISS	21866139	PubMed	PTHR24418:SF244	NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01289	I-Smads	XENTR|Xenbase=XB-GENE-481307|UniProtKB=F6S4W2	Mothers against decapentaplegic homolog	ISS	9335505	PubMed	PTHR13703:SF28	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 6
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	TAKRU|Ensembl=ENSTRUG00000017585|UniProtKB=H2V788	Uncharacterized protein	ISS			PTHR43521:SF1	ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	DROME|FlyBase=FBgn0032650|UniProtKB=Q9VJC2	CG7094	ISS	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00019	Endothelin signaling pathway	P00586	Gq	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	BOVIN|Ensembl=ENSBTAG00000037985|UniProtKB=F1MCK3	Muscarinic acetylcholine receptor	ISS	8100450	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P02721	ATP synthesis	P02796	F1 gamma	ORNAN|Ensembl=ENSOANG00000015444|UniProtKB=F6TI82	ATP synthase subunit gamma	ISS	9525963	PubMed	PTHR11693:SF22	ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	RAT|RGD=3425|UniProtKB=P97887	Presenilin-1	TAS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00050	Plasminogen activating cascade	P01253	Fibrin	PANTR|Ensembl=ENSPTRG00000016534|UniProtKB=H2QQB4	Uncharacterized protein	ISS	223002	gi	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	TAS	12089061	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00375	Calmodulin	STRPU|EnsemblGenome=SPU_005033|UniProtKB=W4XNQ0	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF263	SUBFAMILY NOT NAMED
P00053	T cell activation	P01307	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05916	Opioid prodynorphin pathway	P05999	provasopressin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00049	Parkinson disease	P01230	Src kinase	DANRE|ZFIN=ZDB-GENE-030903-5|UniProtKB=Q6EWH2	Tyrosine-protein kinase fyna	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00019	Endothelin signaling pathway	P00591	PLCbeta	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IGI	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00049	Parkinson disease	P01230	Src kinase	RAT|RGD=2785|UniProtKB=P50545	Tyrosine-protein kinase HCK	IDA	11078745	PubMed	PTHR24418:SF245	TYROSINE-PROTEIN KINASE HCK
P00012	Cadherin signaling pathway	P00474	Wnt	MACMU|Ensembl=ENSMMUG00000006621|UniProtKB=F7HKD3	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00729	Goalpha	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	IDA	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01457	GBeta	ANOGA|EnsemblGenome=AGAP001506|UniProtKB=Q7PXP3	AGAP001506-PA	ISS	11313908	PubMed	PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=2685951|UniProtKB=Q5DU14	Unconventional myosin-XVI	ISS			PTHR13140:SF345	UNCONVENTIONAL MYOSIN-XVI
P00055	Transcription regulation by bZIP transcription factor	P01395	TFIIE	PANTR|Ensembl=ENSPTRG00000015273|UniProtKB=H2QN66	General transcription factor IIE, polypeptide 1, alpha 56kDa	ISS	189962	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MOUSE|MGI=MGI=103307|UniProtKB=P54285	Voltage-dependent L-type calcium channel subunit beta-3	IC			PTHR11824:SF8	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-3
P00057	Wnt signaling pathway	P01443	Phospholipase C	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00030	Hypoxia response via HIF activation	P00819	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01188	Gbetagamma	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00015	Circadian clock system	P00505	Cry	HUMAN|HGNC=2385|UniProtKB=Q49AN0	Cryptochrome-2	IEP	10428031	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00052	TGF-beta signaling pathway	P01275	P38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	TAS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00185	JAK1	MOUSE|MGI=MGI=96628|UniProtKB=P52332	Tyrosine-protein kinase JAK1	ISS	11929133	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P02742	Tetrahydrofolate biosynthesis	P02944	Phosphoribosylglycinamide formyltransferase	MYCTU|EnsemblGenome=Rv0956|UniProtKB=P9WHM5	Phosphoribosylglycinamide formyltransferase	ISS			PTHR43369:SF2	PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	XENTR|Xenbase=XB-GENE-6050844|UniProtKB=F6WNJ9	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00034	Integrin signalling pathway	P00923	Arf1	CANLF|Ensembl=ENSCAFG00000006992|UniProtKB=E2RG67	Uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	HUMAN|HGNC=7155|UniProtKB=P03956	Interstitial collagenase	TAS	12834808	PubMed	PTHR10201:SF151	INTERSTITIAL COLLAGENASE
P00019	Endothelin signaling pathway	P00590	IP3 R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00034	Integrin signalling pathway	P00927	Rac	DICPU|Gene=DICPUDRAFT_92985|UniProtKB=F1A084	Putative uncharacterized protein rac1A	ISS	21127961	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00018	EGF receptor signaling pathway	P00558	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00057	Wnt signaling pathway	P01438	PP2A	HUMAN|HGNC=9299|UniProtKB=P67775	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04393	Ras Pathway	P04574	PLD	PANTR|Ensembl=ENSPTRG00000015626|UniProtKB=H2R1L6	Phospholipase D1, phosphatidylcholine-specific	ISS	9307024	PubMed	PTHR18896:SF57	PHOSPHOLIPASE D1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00053	T cell activation	P01305	Calmodulin	CANLF|Ensembl=ENSCAFG00000016335|UniProtKB=J9NXY2	Uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF322	SUBFAMILY NOT NAMED
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04393	Ras Pathway	P04548	ATF2	CANLF|Ensembl=ENSCAFG00000013332|UniProtKB=F1PCQ4	Uncharacterized protein	ISS	10207617	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00057	Wnt signaling pathway	P01430	p53	PANTR|Ensembl=ENSPTRG00000008703|UniProtKB=H2QC53	Cellular tumor antigen p53	ISS	11313951	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00036	Interleukin signaling pathway	P00990	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00205	GAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00059	p53 pathway	P04623	CBP	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00012	Cadherin signaling pathway	P00470	F-actin	DROME|FlyBase=FBgn0000047|UniProtKB=P83967	Actin, indirect flight muscle	IC	11889126	PubMed	PTHR11937:SF368	ACTIN, INDIRECT FLIGHT MUSCLE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CAEEL|WormBase=WBGene00004037|UniProtKB=Q9XWB7	Phosphoinositide phospholipase C	ISS			PTHR10336:SF9	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	TAS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00021	FGF signaling pathway	P00623	FGF	HUMAN|HGNC=3687|UniProtKB=P31371	Fibroblast growth factor 9	ISS			PTHR11486:SF28	FIBROBLAST GROWTH FACTOR 9
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	PANTR|Ensembl=ENSPTRG00000002339|UniProtKB=H2R368	Uncharacterized protein	ISS	20088160	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00029	Huntington disease	P00777	CBP	ARATH|TAIR=AT1G16710|UniProtKB=Q9FWQ5	Histone acetyltransferase HAC12	IDA	10769018	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00048	PI3 kinase pathway	P01188	Gbetagamma	DICPU|Gene=DICPUDRAFT_93216|UniProtKB=F1A421	Guanine nucleotide-binding protein subunit beta	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00056	VEGF signaling pathway	P01411	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	SCHPO|PomBase=SPBC14C8.06|UniProtKB=P78774	Actin-related protein 2/3 complex subunit 1	ISS	12932731	PubMed	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	MOUSE|MGI=MGI=891996|UniProtKB=Q8C196	Carbamoyl-phosphate synthase [ammonia], mitochondrial	ISS			PTHR11405:SF38	CARBAMOYL-PHOSPHATE SYNTHASE  AMMONIA , MITOCHONDRIAL
P06664	Gonadotropin-releasing hormone receptor pathway	G06895	mPer1	MOUSE|MGI=MGI=1098283|UniProtKB=O35973	Period circadian protein homolog 1	RCA	20570170	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05939	GRK6	MACMU|Ensembl=ENSMMUG00000019817|UniProtKB=F7FY63	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P00012	Cadherin signaling pathway	P00475	Frizzled	CANLF|Ensembl=ENSCAFG00000013159|UniProtKB=E2RAF3	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF79	FRIZZLED-9
P00034	Integrin signalling pathway	P00925	MEK	RAT|RGD=1306620|UniProtKB=B1H230	Map2k3 protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04393	Ras Pathway	P04557	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05917	Opioid proopiomelanocortin pathway	P06011	AC	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00641	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00034	Integrin signalling pathway	P00925	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00059	p53 pathway	P04633	P110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00219	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05915	Opioid proenkephalin pathway	P05994	G-protein	HUMAN|HGNC=4401|UniProtKB=O14775	Guanine nucleotide-binding protein subunit beta-5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00053	T cell activation	P01307	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00049	Parkinson disease	P01242	Casein kinase I	CANLF|Ensembl=ENSCAFG00000000557|UniProtKB=J9P9W3	Uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF151	CASEIN KINASE I ISOFORM GAMMA-3
P05913	Enkephalin release	P05974	G-Protein (i)	XENTR|Xenbase=XB-GENE-963560|UniProtKB=Q0VFC4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00054	Toll receptor signaling pathway	P01368	MKK2	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	RAT|RGD=67385|UniProtKB=Q8VGC3	Voltage-dependent L-type calcium channel subunit beta-2	IC	20088160	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00029	Huntington disease	P00805	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04558	p38	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	IDA	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00021	FGF signaling pathway	P00624	14-3-3	CAEEL|WormBase=WBGene00003920|UniProtKB=P41932	14-3-3-like protein 1	IGI	10407019	PubMed	PTHR18860:SF21	14-3-3-LIKE PROTEIN 1
P00021	FGF signaling pathway	P00628	JNK1-3	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00045	Notch signaling pathway	P01099	Notch	MOUSE|MGI=MGI=97364|UniProtKB=O35516	Neurogenic locus notch homolog protein 2	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00049	Parkinson disease	P01230	Src kinase	HUMAN|HGNC=4037|UniProtKB=P06241	Tyrosine-protein kinase Fyn	IDA	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHICK|Gene=ACTG2|UniProtKB=P63270	Actin, gamma-enteric smooth muscle	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IDA	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00007	Axon guidance mediated by semaphorins	P00331	PAK	CANLF|Ensembl=ENSCAFG00000004956|UniProtKB=E2REH3	Uncharacterized protein	ISS	14580336	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PHYIT|EnsemblGenome=PITG_15117|UniProtKB=D0NRP9	Actin-like protein	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04393	Ras Pathway	P04547	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	BOVIN|Gene=CACNB1|UniProtKB=Q9MZL7	Voltage-dependent L-type calcium channel subunit beta-1	ISS	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P02775	Salvage pyrimidine ribonucleotides	P03149	Cytidine kinase	ARATH|TAIR=AT1G26190|UniProtKB=Q9C664	Phosphoribulokinase/uridine kinase-like protein	ISS			PTHR10285:SF122	URIDINE-CYTIDINE KINASE C
P00057	Wnt signaling pathway	P01443	Phospholipase C	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00839	SHIP	RAT|RGD=68396|UniProtKB=Q9WVR3	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	ISS	10610720	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IDA	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000016067|UniProtKB=F7GIQ3	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF195	BETA-CENTRACTIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01320	PLC-gamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00045	Notch signaling pathway	P01116	Delta	MOUSE|MGI=MGI=104659|UniProtKB=Q61483	Delta-like protein 1	IEP	12175503	PubMed	PTHR24044:SF380	DELTA-LIKE PROTEIN 1
P00029	Huntington disease	P00770	N-CoR	HUMAN|HGNC=7672|UniProtKB=O75376	Nuclear receptor corepressor 1	IPI	10441327	PubMed	PTHR13992:SF5	NUCLEAR RECEPTOR COREPRESSOR 1
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Gene=CHRM2|UniProtKB=Q9N2A7	Muscarinic acetylcholine receptor M2 (Fragment)	ISS	11166329	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00018	EGF receptor signaling pathway	P00557	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IGI	1171954	gi	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	MACMU|Ensembl=ENSMMUG00000011773|UniProtKB=F7HQF4	Uncharacterized protein	ISS	11859080	PubMed	PTHR24247:SF31	5-HYDROXYTRYPTAMINE RECEPTOR 2B
P00047	PDGF signaling pathway	P01173	STAT	CANLF|Ensembl=ENSCAFG00000015346|UniProtKB=E2RE22	Signal transducer and activator of transcription	ISS	95236292	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00010	B cell activation	P00377	Ig-beta	PANTR|Ensembl=ENSPTRG00000009531|UniProtKB=H2QDN8	Uncharacterized protein	ISS	11136817	PubMed	PTHR14334:SF2	B-CELL ANTIGEN RECEPTOR COMPLEX-ASSOCIATED PROTEIN BETA CHAIN
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	RAT|RGD=628852|UniProtKB=Q02294	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	11976940	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P02728	Arginine biosynthesis	P02848	N-acetylglutamate synthase	MOUSE|MGI=MGI=2387600|UniProtKB=Q8R4H7	N-acetylglutamate synthase, mitochondrial	ISS			PTHR23342:SF0	N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL
P00059	p53 pathway	P04610	Cyclin E	RAT|RGD=2294|UniProtKB=P39949	G1/S-specific cyclin-E1	IDA	6671698	gi	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00057	Wnt signaling pathway	P01465	Ggamma	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01161	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	PANTR|Ensembl=ENSPTRG00000009871|UniProtKB=H2QE95	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05916	Opioid prodynorphin pathway	P06002	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00006	Apoptosis signaling pathway	P00260	AKT	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	ISS	95181376	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Ensembl=ENSGALG00000028896|UniProtKB=R4GMK5	Uncharacterized protein	IEP	10938134	PubMed	PTHR13140:SF728	MYOSIN HEAVY CHAIN, SKELETAL MUSCLE, ADULT
P00059	p53 pathway	P04616	PDK1/2	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	TAS	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	7565716	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	TAS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06778	TGFbeta	MOUSE|MGI=MGI=98726|UniProtKB=P27090	Transforming growth factor beta-2	RCA	9759503	PubMed	PTHR11848:SF141	TRANSFORMING GROWTH FACTOR BETA-2
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00034	Integrin signalling pathway	P00907	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00037	Ionotropic glutamate receptor pathway	P01020	NSF	MACMU|Ensembl=ENSMMUG00000005548|UniProtKB=F6YT14	Uncharacterized protein	ISS	11348590	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IC	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00168	E-cadherin intracellular fragment	PANTR|Ensembl=ENSPTRG00000008270|UniProtKB=H2QBE5	Uncharacterized protein	ISS	12834808	PubMed	PTHR24027:SF319	CADHERIN-1
P00005	Angiogenesis	P00249	PAK	CHICK|Ensembl=ENSGALG00000000681|UniProtKB=E1C3P6	Uncharacterized protein	ISS	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	HUMAN|HGNC=10013|UniProtKB=Q15835	Rhodopsin kinase	IDA	8288567	PubMed	PTHR24355:SF11	RHODOPSIN KINASE
P00054	Toll receptor signaling pathway	P01355	AP1	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	8837781	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00023	General transcription regulation	P00670	TBP	ORNAN|Ensembl=ENSOANG00000013097|UniProtKB=F6UVN1	Uncharacterized protein	ISS	600075	OMIM	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00018	EGF receptor signaling pathway	P00547	PP2A	YEAST|SGD=S000002482|UniProtKB=P32345	Serine/threonine-protein phosphatase 4 catalytic subunit	ISS			PTHR11668:SF22	SERINE/THREONINE-PROTEIN PHOSPHATASE 4 CATALYTIC SUBUNIT
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	IDA	8557110	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00006	Apoptosis signaling pathway	P00271	Bax	MOUSE|MGI=MGI=99702|UniProtKB=Q07813	Apoptosis regulator BAX	IDA	8358790	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	CHICK|Ensembl=ENSGALG00000009320|UniProtKB=Q4JIM4	Presenilin-1	TAS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01067	AChE	PANTR|Ensembl=ENSPTRG00000015593|UniProtKB=H2QNP1	Carboxylic ester hydrolase	ISS	87080761	PubMed	PTHR43918:SF5	CHOLINESTERASE
P00049	Parkinson disease	P01233	Elk-1	STRPU|EnsemblGenome=SPU_012469|UniProtKB=Q95UJ1	Transcription factor Elk	IDA	11279280	PubMed	PTHR11849:SF133	LIN-1
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05995	proenkephalin	MACMU|Ensembl=ENSMMUG00000006775|UniProtKB=F7H3N8	Uncharacterized protein	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00029	Huntington disease	P00796	Kainate receptor	MACMU|Ensembl=ENSMMUG00000009679|UniProtKB=F6YBQ8	Uncharacterized protein	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00256	PLC-gamma	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00048	PI3 kinase pathway	P01198	FOXO	MACMU|Ensembl=ENSMMUG00000020369|UniProtKB=F6UMX8	Uncharacterized protein	ISS	12884295	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00053	T cell activation	P01303	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	4504111	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IDA	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	YEAST|SGD=S000001855|UniProtKB=P60010	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Ensembl=ENSCAFG00000010787|UniProtKB=E2R3W6	Uncharacterized protein	ISS	2137198	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IDA	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	IDA	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	ORNAN|Ensembl=ENSOANG00000015652|UniProtKB=F7FY70	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	CHLRE|EnsemblGenome=CHLREDRAFT_194461|UniProtKB=Q8W4V3	Serine hydroxymethyltransferase	ISS			PTHR11680:SF21	SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC
P02752	Mannose metabolism	P03018	Mannose 1-P guanylyl transferase	ARATH|TAIR=AT2G04650|UniProtKB=F4IFA4	ADP-glucose pyrophosphorylase-like protein	NAS	17064890	gi	PTHR22572:SF123	ADP-GLUCOSE PYROPHOSPHORYLASE-LIKE PROTEIN
P00035	Interferon-gamma signaling pathway	P00956	SOCS	MACMU|Ensembl=ENSMMUG00000000304|UniProtKB=F6YVE7	Suppressor of cytokine signaling 4	ISS	10500304	PubMed	PTHR44282:SF2	SUPPRESSOR OF CYTOKINE SIGNALING 4
P05913	Enkephalin release	P05972	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	ISS	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00890	ELK	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	ISS	10487205	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CHICK|Ensembl=ENSGALG00000009621|UniProtKB=P60706	Actin, cytoplasmic 1	ISS	11889139	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	BOVIN|Ensembl=ENSBTAG00000000992|UniProtKB=E1B8X7	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF39	BONE MORPHOGENETIC PROTEIN 10
P00018	EGF receptor signaling pathway	P00543	ERK1-2	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	HUMAN|HGNC=7850|UniProtKB=P22392	Nucleoside diphosphate kinase B	ISS			PTHR11349:SF57	NUCLEOSIDE DIPHOSPHATE KINASE B
P00059	p53 pathway	P01485	p53	MOUSE|MGI=MGI=98834|UniProtKB=P02340	Cellular tumor antigen p53	TAS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00048	PI3 kinase pathway	P01188	Gbetagamma	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P05915	Opioid proenkephalin pathway	P05993	AC	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00029	Huntington disease	P00807	Actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347736|UniProtKB=E9FRT1	Muscle-specific actin	ISS	14684598	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MACMU|Ensembl=ENSMMUG00000019112|UniProtKB=F6T8S6	N-methyl D-aspartate receptor subtype 2B	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	PANTR|Ensembl=ENSPTRG00000004718|UniProtKB=H2Q5I0	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00265	Granzyme B	HUMAN|HGNC=4710|UniProtKB=P20718	Granzyme H	ISS			PTHR24271:SF15	GRANZYME H
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00546	GAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00052	TGF-beta signaling pathway	P01284	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Gene=OPRM1|UniProtKB=Q5IS39	Mu-type opioid receptor	ISS	11259498	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00018	EGF receptor signaling pathway	P00552	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00036	Interleukin signaling pathway	P00990	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05918	p38 MAPK pathway	P06032	MKK6	MONDO|Ensembl=ENSMODG00000006330|UniProtKB=F7AGV5	Uncharacterized protein	ISS	8622669	PubMed	PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P00045	Notch signaling pathway	P01102	Sel 10	PANTR|Ensembl=ENSPTRG00000016514|UniProtKB=H2QQA2	F-box and WD repeat domain containing 7	ISS			PTHR44007:SF6	F-BOX/WD REPEAT-CONTAINING PROTEIN 7
P00005	Angiogenesis	P00223	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00021	FGF signaling pathway	P00627	ERK1-2	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IGI	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00643	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04559	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12960248	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	MOUSE|MGI=MGI=1351340|UniProtKB=Q9QYS2	Metabotropic glutamate receptor 3	ISS	12351712	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00050	Plasminogen activating cascade	P01256	uPAR	HUMAN|HGNC=9053|UniProtKB=Q03405	Urokinase plasminogen activator surface receptor	IEA	4505865	gi	PTHR10624:SF6	UROKINASE PLASMINOGEN ACTIVATOR SURFACE RECEPTOR
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	IC	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00045	Notch signaling pathway	P01120	NIcs	HUMAN|HGNC=7884|UniProtKB=Q99466	Neurogenic locus notch homolog protein 4	ISS	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ARATH|TAIR=AT2G42100|UniProtKB=Q8RYC2	Putative actin-5	IC	10974003	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	1650351	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04395	Vasopressin synthesis	P04597	Signal Peptide	MOUSE|MGI=MGI=97453|UniProtKB=P35454	Oxytocin-neurophysin 1	ISS	3768139	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	IDA	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04397	p53 pathway by glucose deprivation	P04641	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01423	p38MAPK	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02743	Formyltetrahydroformate biosynthesis	P02954	Thymidylate synthase	YEAST|SGD=S000005600|UniProtKB=P06785	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00203	Erk	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00012	Cadherin signaling pathway	P00470	F-actin	ORYSJ|EnsemblGenome=OS11G0163100|UniProtKB=Q67G20	Actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	P01461	FrzB	XENTR|Xenbase=XB-GENE-876718|UniProtKB=Q6F2E8	Frzb2	ISS	10960783	PubMed	PTHR11309:SF12	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01286	TGFbeta	PANTR|Ensembl=ENSPTRG00000013656|UniProtKB=H2QKM7	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF135	BONE MORPHOGENETIC PROTEIN 7
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04393	Ras Pathway	P04542	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P02724	Alanine biosynthesis	P02815	Branched chain amino acid aminotransferase	PSEAE|EnsemblGenome=PA5013|UniProtKB=O86428	Branched-chain-amino-acid aminotransferase	ISS			PTHR42743:SF3	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE-LIKE PROTEIN 1-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	RCA	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01457	GBeta	DICPU|Gene=DICPUDRAFT_93216|UniProtKB=F1A421	Guanine nucleotide-binding protein subunit beta	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00049	Parkinson disease	P01211	ERK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	IDA	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	RAT|RGD=620967|UniProtKB=F1M9D0	Protein Map3k2	ISS	8621389	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00006	Apoptosis signaling pathway	P00316	Bcl-w	MONDO|Ensembl=ENSMODG00000004539|UniProtKB=F6U940	Uncharacterized protein	ISS	8761287	PubMed	PTHR11256:SF13	BCL-2-LIKE PROTEIN 2
P00049	Parkinson disease	P01237	Complex I	CAEBR|Gene=CBG11518|UniProtKB=A8XCT2	Protein CBG11518	ISS	3100899	PubMed	PTHR10371:SF3	NADH DEHYDROGENASE  UBIQUINONE  FLAVOPROTEIN 2, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DANRE|ZFIN=ZDB-GENE-030131-172|UniProtKB=Q6IQR3	Actin, alpha, cardiac muscle 1a	IC	14684598	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04371	5-Hydroxytryptamine biosynthesis	P04400	Aromatic L-amino acid decarboxylase	ORYSJ|EnsemblGenome=OS01G0770200|UniProtKB=Q94EE9	Os01g0770200 protein	ISS			PTHR11999:SF96	SUBFAMILY NOT NAMED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BOVIN|Gene=ACTB|UniProtKB=P60712	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00057	Wnt signaling pathway	P01435	SWI/SNF	RAT|RGD=1310500|UniProtKB=D4A3E3	Protein Arid1a	ISS	11532957	PubMed	PTHR12656:SF12	AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 1A
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05960	VAT2	MOUSE|MGI=MGI=106677|UniProtKB=Q8BRU6	Synaptic vesicular amine transporter	IC	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	ANOGA|EnsemblGenome=AGAP002440|UniProtKB=Q17031	Cdc42 homolog	ISS	9658176	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00010	B cell activation	P00381	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00019	Endothelin signaling pathway	P00572	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT1G01560|UniProtKB=Q9LMM5	Mitogen-activated protein kinase 11	ISS	11707292	PubMed	PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	P01448	CBP	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00034	Integrin signalling pathway	P00951	Jnk	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04393	Ras Pathway	P04572	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IDA	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BOVIN|Ensembl=ENSBTAG00000006189|UniProtKB=P63258	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P04393	Ras Pathway	P04572	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	BOVIN|Ensembl=ENSBTAG00000013657|UniProtKB=Q8SPU7	Neuronal acetylcholine receptor subunit alpha-5	ISS	12388584	PubMed	PTHR18945:SF76	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5
P00005	Angiogenesis	P00255	Notch	MACMU|Ensembl=ENSMMUG00000017022|UniProtKB=F7HQZ9	Uncharacterized protein	ISS	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	NAS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05915	Opioid proenkephalin pathway	P05994	G-protein	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00006	Apoptosis signaling pathway	P00269	MAPK	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF330	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	MOUSE|MGI=MGI=106217|UniProtKB=Q61290	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	14624853	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CANLF|Ensembl=ENSCAFG00000002617|UniProtKB=E2QUL1	Uncharacterized protein	ISS	11319238	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	PSEAE|EnsemblGenome=PA3134|UniProtKB=Q9XCL6	Glutamate--tRNA ligase	ISS			PTHR43311:SF2	GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED
P00010	B cell activation	P00371	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	PANTR|Ensembl=ENSPTRG00000003554|UniProtKB=H2Q3I3	Low density lipoprotein receptor-related protein 4	ISS	11907044	PubMed	PTHR44017:SF4	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02738	De novo purine biosynthesis	P02909	GDP reductase	THEMA|EnsemblGenome=TM_0118|UniProtKB=G4FH33	Ribonucleotide reductase of class II (Coenzyme B12-dependent)	ISS			PTHR43371:SF1	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IPI	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01194	S6K	CANLF|Ensembl=ENSCAFG00000017679|UniProtKB=E2RMD8	Ribosomal protein S6 kinase	ISS	11861821	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00021	FGF signaling pathway	P00629	PP2A	TRIAD|EnsemblGenome=TriadG63380|UniProtKB=B3S653	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P01486	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01417	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00256	PLC-gamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	IXOSC|EnsemblGenome=ISCW024111|UniProtKB=B7PBG2	Actin, putative (Fragment)	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00019	Endothelin signaling pathway	P00572	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04398	p53 pathway feedback loops 2	P04665	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P06587	Nicotine pharmacodynamics pathway	P06611	CLIC6	HUMAN|HGNC=2065|UniProtKB=Q96NY7	Chloride intracellular channel protein 6	RCA	14499480	PubMed	PTHR45476:SF1	CHLORIDE INTRACELLULAR CHANNEL PROTEIN 6
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00036	Interleukin signaling pathway	P00983	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IC	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01164	PDK1/2	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00018	EGF receptor signaling pathway	P00542	EGFR	MONDO|Ensembl=ENSMODG00000015755|UniProtKB=F6ZSZ9	Uncharacterized protein (Fragment)	ISS	4884676	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00057	Wnt signaling pathway	P01465	Ggamma	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00010	B cell activation	P00391	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	IGI	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P06664	Gonadotropin-releasing hormone receptor pathway	G06684	Annexin A5	MOUSE|MGI=MGI=106008|UniProtKB=P48036	Annexin A5	RCA			PTHR10502:SF26	ANNEXIN A5
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	IC	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CANLF|Gene=GRIN1|UniProtKB=Q5R1P0	Glutamate receptor ionotropic, NMDA 1	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00053	T cell activation	P01312	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IDA	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00049	Parkinson disease	P01242	Casein kinase I	YEAST|SGD=S000000925|UniProtKB=P39962	Casein kinase I homolog 3	IDA	10617630	PubMed	PTHR11909:SF155	GILGAMESH, ISOFORM L
P04393	Ras Pathway	P04570	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P02774	Salvage pyrimidine deoxyribonucleotides	P03147	Thymidine kinase	ARATH|TAIR=AT3G07800|UniProtKB=Q9S750	Thymidine kinase a	ISS			PTHR11441:SF0	THYMIDINE KINASE, CYTOSOLIC
P00048	PI3 kinase pathway	P01206	14-3-3	MOUSE|MGI=MGI=109484|UniProtKB=P63101	14-3-3 protein zeta/delta	ISS	92362864	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00059	p53 pathway	P04630	PP2A	BOVIN|Ensembl=ENSBTAG00000000469|UniProtKB=P67774	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IPI	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00385	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00046	Oxidative stress response	P01125	Stat1	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	15825084	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04559	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00029	Huntington disease	P00775	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12676940	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00056	VEGF signaling pathway	P01407	Erk	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00022	General transcription by RNA polymerase I	P00657	TBP	SCHPO|PomBase=SPAC29E6.08|UniProtKB=P17871	TATA-box-binding protein	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00012	Cadherin signaling pathway	P00474	Wnt	RAT|RGD=69346|UniProtKB=G3V7U3	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00012	Cadherin signaling pathway	P00474	Wnt	PANTR|Ensembl=ENSPTRG00000009322|UniProtKB=H2REI3	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF84	PROTEIN WNT-9B
P04393	Ras Pathway	P04558	p38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	BOVIN|Ensembl=ENSBTAG00000035370|UniProtKB=Q32LB1	TATA box-binding protein-like protein 1	ISS	600075	OMIM	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00049	Parkinson disease	P01211	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=12788|UniProtKB=Q9H1J5	Protein Wnt-8a	TAS	8717036	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00029	Huntington disease	P00807	Actin	CANLF|Ensembl=ENSCAFG00000015708|UniProtKB=F2Z4N0	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00029	Huntington disease	P00807	Actin	RAT|RGD=628837|UniProtKB=P60711	Actin, cytoplasmic 1	IDA	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00045	Notch signaling pathway	P01114	Ntm	RAT|RGD=1303282|UniProtKB=Q6MG89	Notch homolog 4, [Drosophila]	ISS	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000022319|UniProtKB=F6XDA0	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00046	Oxidative stress response	P01135	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00029	Huntington disease	P00780	Microtubule	MOUSE|MGI=MGI=107848|UniProtKB=Q9D6F9	Tubulin beta-4A chain	IDA	9454836	PubMed	PTHR11588:SF253	TUBULIN BETA-4A CHAIN
P00029	Huntington disease	P00786	ARF	PLAF7|EnsemblGenome=PF10_0203|UniProtKB=Q7KQL3	ADP-ribosylation factor 1	IPI	12932731	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00924	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00805	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	PANTR|Ensembl=ENSPTRG00000023062|UniProtKB=H2R2U1	Catenin (Cadherin-associated protein), beta 1, 88kDa	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	XENTR|Xenbase=XB-GENE-491938|UniProtKB=Q6DIV8	Actin, alpha 1, skeletal muscle	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00012	Cadherin signaling pathway	P00471	Cadherin	BOVIN|Ensembl=ENSBTAG00000014169|UniProtKB=E1BDF9	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF40	PROTOCADHERIN-19
P00053	T cell activation	P01300	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	MOUSE|MGI=MGI=103296|UniProtKB=P97305	Nuclear factor of activated T-cells, cytoplasmic 3	ISS	9133421	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00047	PDGF signaling pathway	P01159	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00056	VEGF signaling pathway	P01423	p38MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01458	Protein Kinase C	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	IDA	15572354	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ORYSJ|EnsemblGenome=OS05G0106600|UniProtKB=Q65XH8	Os05g0106600 protein	IDA	11889126	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04580	TRH Receptor	CAEEL|WormBase=WBGene00016265|UniProtKB=Q95YD7	NMUR (NeuroMedin U Receptor) homolog	ISS			PTHR24243:SF197	NMUR  NEUROMEDIN U RECEPTOR  HOMOLOG
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	176910	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04561	SRF	RAT|RGD=1559787|UniProtKB=D3ZHH8	Protein Srf	ISS	15170389	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00048	PI3 kinase pathway	P01182	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	HUMAN|HGNC=3373|UniProtKB=Q09472	Histone acetyltransferase p300	ISS	10769018	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00049	Parkinson disease	P01240	hSel10	ORNAN|Ensembl=ENSOANG00000007791|UniProtKB=F6YUQ2	Uncharacterized protein	ISS			PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DROME|FlyBase=FBgn0010223|UniProtKB=Q05337	Guanine nucleotide-binding protein G(f) subunit alpha	IC	2106672	PubMed	PTHR10218:SF229	GUANINE NUCLEOTIDE-BINDING PROTEIN G F  SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00469	Fer	BOVIN|Ensembl=ENSBTAG00000003051|UniProtKB=E1BNE0	Tyrosine-protein kinase	ISS	9742093	PubMed	PTHR24418:SF227	TYROSINE-PROTEIN KINASE FER
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00640	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00226	Delta/Serrate	HUMAN|HGNC=2908|UniProtKB=O00548	Delta-like protein 1	ISS			PTHR24044:SF380	DELTA-LIKE PROTEIN 1
P04397	p53 pathway by glucose deprivation	P04641	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P02751	Lysine biosynthesis	P03008	Dihydrodipicolinate synthase	THEMA|EnsemblGenome=TM_1521|UniProtKB=Q9X1K9	4-hydroxy-tetrahydrodipicolinate synthase	ISS			PTHR12128:SF15	4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	RAT|RGD=2089|UniProtKB=P05065	Fructose-bisphosphate aldolase A	ISS	6086339	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00006	Apoptosis signaling pathway	P00274	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01173	STAT	PANTR|Ensembl=ENSPTRG00000009199|UniProtKB=H2QD19	Signal transducer and activator of transcription	ISS	96210005	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00012	Cadherin signaling pathway	P00467	alpha-catenin	MACMU|Ensembl=ENSMMUG00000000293|UniProtKB=F6YFG3	Uncharacterized protein	ISS	1768802	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	HUMAN|HGNC=5291|UniProtKB=P28566	5-hydroxytryptamine receptor 1E	ISS	1608964	PubMed	PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P00053	T cell activation	P01329	CD45	CHICK|Ensembl=ENSGALG00000002192|UniProtKB=F1NVB1	Uncharacterized protein	IGI	1672451	PubMed	PTHR19134:SF284	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MACMU|Ensembl=ENSMMUG00000017374|UniProtKB=F7H6T7	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00057	Wnt signaling pathway	P01458	Protein Kinase C	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	IDA	10747026	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	TAKRU|Ensembl=ENSTRUG00000001238|UniProtKB=H2RRV9	Glutamine synthetase	ISS			PTHR20852:SF45	GLUTAMINE SYNTHETASE
P00057	Wnt signaling pathway	P01437	TCF	MACMU|Ensembl=ENSMMUG00000023256|UniProtKB=F7HPX5	Uncharacterized protein	ISS	9039917	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P02738	De novo purine biosynthesis	P02905	Amidophosphoribosyl transferase	DROME|FlyBase=FBgn0041194|UniProtKB=Q967S0	Amidophosphoribosyltransferase	ISS			PTHR11907:SF18	AMIDOPHOSPHORIBOSYLTRANSFERASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02734	Chorismate biosynthesis	P02868	Chorismate synthase	FUSNN|EnsemblGenome=FN0934|UniProtKB=Q8REZ6	Chorismate synthase	ISS			PTHR21085:SF0	CHORISMATE SYNTHASE
P04397	p53 pathway by glucose deprivation	P04641	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	12655147	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04572	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	IDA	7600581	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	MOUSE|MGI=MGI=97356|UniProtKB=Q01768	Nucleoside diphosphate kinase B	ISS			PTHR11349:SF57	NUCLEOSIDE DIPHOSPHATE KINASE B
P00049	Parkinson disease	P01208	Hsp70	DROME|FlyBase=FBgn0001230|UniProtKB=O97125	Heat shock protein 68	IDA	12150907	PubMed	PTHR19375:SF256	HSP70 PROTEIN-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00009	Axon guidance mediated by netrin	P00363	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00010	B cell activation	P00371	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	CANLF|Ensembl=ENSCAFG00000004930|UniProtKB=E2RFB5	Uncharacterized protein	ISS	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	TAKRU|Ensembl=ENSTRUG00000007989|UniProtKB=P68140	Actin, alpha skeletal muscle A	IDA	11889139	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00005	Angiogenesis	P00220	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05943	GRK2	PANTR|Ensembl=ENSPTRG00000003946|UniProtKB=H2Q482	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P00012	Cadherin signaling pathway	P00474	Wnt	RAT|RGD=69250|UniProtKB=Q9QXQ7	Protein Wnt-5a	IDA	11266476	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	YEAST|SGD=S000003272|UniProtKB=P14681	Mitogen-activated protein kinase KSS1	ISS	10851062	PubMed	PTHR24055:SF338	MITOGEN-ACTIVATED PROTEIN KINASE KSS1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00565	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IGI	22040490	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	ISS	11554549	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00029	Huntington disease	P00796	Kainate receptor	XENTR|Xenbase=XB-GENE-957124|UniProtKB=F7BDN8	Uncharacterized protein	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00057	Wnt signaling pathway	P01457	GBeta	CAEEL|WormBase=WBGene00001679|UniProtKB=P17343	Guanine nucleotide-binding protein subunit beta-1	IDA	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00560	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_206575|UniProtKB=E9FUX0	Guanine nucleotide binding protein, beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00047	PDGF signaling pathway	P01148	Grb2	CAEBR|Gene=CBG16856|UniProtKB=A8XPY6	Protein CBR-SEM-5	ISS	51702266	gi	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	RAT|RGD=3784|UniProtKB=P61265	Syntaxin-1B	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P04397	p53 pathway by glucose deprivation	P04641	Akt	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	ISS	14526383	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00160	Nectin 1alpha	HUMAN|HGNC=9706|UniProtKB=Q15223	Nectin-1	ISS	12376527	PubMed	PTHR23277:SF69	NECTIN-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00034	Integrin signalling pathway	P00944	Actin	PANTR|Ensembl=ENSPTRG00000009762|UniProtKB=H2QE24	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00207	Crk	PANTR|Ensembl=ENSPTRG00000008522|UniProtKB=H2QBT8	Uncharacterized protein	ISS	8649368	PubMed	PTHR19969:SF8	ADAPTER MOLECULE CRK
P00034	Integrin signalling pathway	P00941	Integrin alpha	BOVIN|Ensembl=ENSBTAG00000017266|UniProtKB=E1BFQ6	Uncharacterized protein	ISS	3487386	PubMed	PTHR23220:SF9	INTEGRIN ALPHA-6
P00017	DNA replication	P00527	Histones	DROME|FlyBase=FBgn0004828|UniProtKB=P84249	Histone H3.3	ISS	20448842	PubMed	PTHR11426:SF179	HISTONE H3.3
P00019	Endothelin signaling pathway	P00566	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00056	VEGF signaling pathway	P01408	Akt/PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00050	Plasminogen activating cascade	P01247	TAFI	MOUSE|MGI=MGI=1891837|UniProtKB=Q9JHH6	Carboxypeptidase B2	IDA	22305040	PubMed	PTHR11705:SF17	CARBOXYPEPTIDASE B2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS			PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00049	Parkinson disease	P01236	Casein kinase II	DAPPU|EnsemblGenome=DAPPUDRAFT_305830|UniProtKB=E9GTE8	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00047	PDGF signaling pathway	P01142	p90RSK	HUMAN|HGNC=10431|UniProtKB=Q15349	Ribosomal protein S6 kinase alpha-2	ISS	1922062	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	HUMAN|HGNC=11641|UniProtKB=Q9NQB0	Transcription factor 7-like 2	IEP	9118222	PubMed	PTHR10373:SF32	TRANSCRIPTION FACTOR 7-LIKE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P02775	Salvage pyrimidine ribonucleotides	P03156	CDP kinase	RAT|RGD=620742|UniProtKB=Q9QYG8	Uridine-cytidine kinase 2	ISS			PTHR10285:SF70	URIDINE-CYTIDINE KINASE 2
P00036	Interleukin signaling pathway	P00964	p90RSK	HUMAN|HGNC=10430|UniProtKB=Q15418	Ribosomal protein S6 kinase alpha-1	ISS	15226426	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	2837282	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00049	Parkinson disease	P01236	Casein kinase II	DANRE|ZFIN=ZDB-GENE-040625-181|UniProtKB=Q6IQV0	Uncharacterized protein	ISS	10806215	PubMed	PTHR24054:SF28	CASEIN KINASE 2 ALPHA 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DANRE|ZFIN=ZDB-GENE-040426-1178|UniProtKB=Q7SY24	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00034	Integrin signalling pathway	P00920	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	TAKRU|Ensembl=ENSTRUG00000011280|UniProtKB=H2TUW3	Protein Wnt	TAS	11266476	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00015	Circadian clock system	P00504	Per	MACMU|Ensembl=ENSMMUG00000021798|UniProtKB=F7ESU2	Uncharacterized protein	ISS	12782655	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	DROME|FlyBase=FBgn0040509|UniProtKB=Q9VK52	ACXB	IGI			PTHR11920:SF338	ACXA, ISOFORM A-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	RAT|RGD=3274|UniProtKB=P23377	Furin	IDA	11861638	PubMed	PTHR42884:SF1	FURIN
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	RAT|RGD=621534|UniProtKB=P43144	Neuronal acetylcholine receptor subunit alpha-9	IC			PTHR18945:SF489	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-9
P00023	General transcription regulation	P00658	TBP-associated factors	DROME|FlyBase=FBgn0010280|UniProtKB=P47825	Transcription initiation factor TFIID subunit 4	ISS	10973244	PubMed	PTHR15138:SF14	IP01149P-RELATED
P00049	Parkinson disease	P01208	Hsp70	SCHMA|EnsemblGenome=Smp_049550|UniProtKB=G4V910	Putative heat shock protein 70 (Hsp70)	ISS	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P02788	Xanthine and guanine salvage pathway	P03247	Xanthine phosphoribosyl transferase	MOUSE|MGI=MGI=96217|UniProtKB=P00493	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF6	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE
P05734	Synaptic vesicle trafficking	P05775	Synapsin	TAKRU|Ensembl=ENSTRUG00000006203|UniProtKB=H2SRR1	Uncharacterized protein	ISS	600755	OMIM	PTHR10841:SF20	SYNAPSIN-2
P00018	EGF receptor signaling pathway	P00564	Rac	ORYSJ|EnsemblGenome=OS02G0120800|UniProtKB=Q6ZHA3	Rac-like GTP-binding protein 6	ISS	21948222	PubMed	PTHR24072:SF261	SUBFAMILY NOT NAMED
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT2G43790|UniProtKB=Q39026	Mitogen-activated protein kinase 6	ISS	10514528	PubMed	PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	HUMAN|HGNC=6267|UniProtKB=P48051	G protein-activated inward rectifier potassium channel 2	ISS	2433589	PubMed	PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	PANTR|Ensembl=ENSPTRG00000006175|UniProtKB=H2R2N7	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF721	MYOSIN-6
P04393	Ras Pathway	P04570	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	IDA	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	BOVIN|Ensembl=ENSBTAG00000005800|UniProtKB=F1N3G8	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	HUMAN|HGNC=10610|UniProtKB=P51671	Eotaxin	ISS			PTHR12015:SF146	EOTAXIN
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	NEUCR|EnsemblGenome=EFNCRG00000000159|UniProtKB=F5HH30	Guanine nucleotide-binding protein beta subunit	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04393	Ras Pathway	P04579	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	95096035	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	IDA	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00036	Interleukin signaling pathway	P00973	PKB	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00046	Oxidative stress response	P01131	MKP5	CANLF|Ensembl=ENSCAFG00000018142|UniProtKB=E2RB57	Uncharacterized protein	ISS			PTHR10159:SF338	DUAL SPECIFICITY PROTEIN PHOSPHATASE 14
P02738	De novo purine biosynthesis	P02889	dGDP kinase	ARATH|TAIR=AT4G11010|UniProtKB=O49203	Nucleoside diphosphate kinase III, chloroplastic/mitochondrial	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00004	Alzheimer disease-presenilin pathway	P00137	Tip60	HUMAN|HGNC=5275|UniProtKB=Q92993	Histone acetyltransferase KAT5	IDA	11441186	PubMed	PTHR10615:SF124	HISTONE ACETYLTRANSFERASE KAT5
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MONDO|Ensembl=ENSMODG00000007194|UniProtKB=F6X9N6	Actin-related protein 2/3 complex subunit 5	ISS	9230079	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00005	Angiogenesis	P00243	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00542	EGFR	PANTR|Ensembl=ENSPTRG00000012883|UniProtKB=H2QJC5	Receptor protein-tyrosine kinase	ISS	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00045	Notch signaling pathway	P01104	Serrate	MONDO|Ensembl=ENSMODG00000004910|UniProtKB=F7C1Q4	Delta-like protein	ISS	12826675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00054	Toll receptor signaling pathway	P01358	ERK1	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00056	VEGF signaling pathway	P01411	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000023940|UniProtKB=F6RFW8	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00010	B cell activation	P00380	fos	MACMU|Ensembl=ENSMMUG00000010574|UniProtKB=A5A6H2	C-fos	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	HUMAN|HGNC=411|UniProtKB=P48448	Aldehyde dehydrogenase family 3 member B2	IC			PTHR43570:SF6	ALDEHYDE DEHYDROGENASE FAMILY 3 MEMBER B2
P05913	Enkephalin release	P05974	G-Protein (i)	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00238	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00054	Toll receptor signaling pathway	P01355	AP1	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00047	PDGF signaling pathway	P01154	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	ORNAN|Ensembl=ENSOANG00000008907|UniProtKB=F7EDR2	Receptor protein serine/threonine kinase	ISS			PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	88241036	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00048	PI3 kinase pathway	P01192	p110	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00046	Oxidative stress response	P01129	JNK1/2	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P02743	Formyltetrahydroformate biosynthesis	P02954	Thymidylate synthase	DROME|FlyBase=FBgn0024920|UniProtKB=O76511	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PANTR|Ensembl=ENSPTRG00000009214|UniProtKB=H2QD31	Uncharacterized protein	ISS			PTHR22903:SF17	PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY H MEMBER 3
P02729	Ascorbate degradation	P02849	L-xylulose kinase	THEMA|EnsemblGenome=TM_0443|UniProtKB=Q9WYS4	Gluconate kinase	ISS			PTHR43095:SF2	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00587	Raf-1	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS			PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	RCA	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00048	PI3 kinase pathway	P01177	P110ACT	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00821	Prolyl Hydroxylase	MACMU|Ensembl=ENSMMUG00000005247|UniProtKB=F7BR59	Uncharacterized protein	ISS	12912907	PubMed	PTHR12907:SF4	EGL NINE HOMOLOG 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	BOVIN|Ensembl=ENSBTAG00000013498|UniProtKB=Q75Z89	5-hydroxytryptamine receptor 2A	ISS			PTHR24247:SF30	5-HYDROXYTRYPTAMINE RECEPTOR 2A
P05918	p38 MAPK pathway	P06020	p38delta	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	RCA	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00054	Toll receptor signaling pathway	P01358	ERK1	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00056	VEGF signaling pathway	P01418	Paxillin	MOUSE|MGI=MGI=2147677|UniProtKB=Q99N69	Leupaxin	ISS			PTHR24216:SF23	LEUPAXIN
P00005	Angiogenesis	P00215	Nck	MONDO|Ensembl=ENSMODG00000018540|UniProtKB=F7GD33	Uncharacterized protein	ISS	12874226	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P05918	p38 MAPK pathway	P06015	p38gamma	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	RCA	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04395	Vasopressin synthesis	P04597	Signal Peptide	TAKRU|Ensembl=ENSTRUG00000015631|UniProtKB=H2USP0	Uncharacterized protein	ISS	9756087	PubMed	PTHR11681:SF14	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04398	p53 pathway feedback loops 2	G04714	PTEN	CAEEL|WormBase=WBGene00000913|UniProtKB=G5EE01	DAF-18	ISS	9885576	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00049	Parkinson disease	P01230	Src kinase	CANLF|Ensembl=ENSCAFG00000003995|UniProtKB=E2RC09	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P04393	Ras Pathway	P04557	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04542	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MOUSE|MGI=MGI=1915115|UniProtKB=Q9CQE5	Regulator of G-protein signaling 10	IDA	8756726	PubMed	PTHR10845:SF182	REGULATOR OF G-PROTEIN SIGNALING 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	ARATH|TAIR=AT3G43810|UniProtKB=P59220	Calmodulin-7	ISS			PTHR23050:SF250	CALMODULIN-7
P04393	Ras Pathway	P04543	MEKK1/4	HUMAN|HGNC=6856|UniProtKB=Q9Y6R4	Mitogen-activated protein kinase kinase kinase 4	IDA	12878610	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P05734	Synaptic vesicle trafficking	P05775	Synapsin	DROME|FlyBase=FBgn0004575|UniProtKB=Q24546	Synapsin	TAS	8627354	PubMed	PTHR10841:SF17	SYNAPSIN
P00005	Angiogenesis	P00251	cPLA2	BOVIN|Ensembl=ENSBTAG00000013298|UniProtKB=A4IFJ5	Cytosolic phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00019	Endothelin signaling pathway	P00568	PKC	DANRE|ZFIN=ZDB-GENE-040426-1354|UniProtKB=Q7T2C5	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=96273|UniProtKB=Q64264	5-hydroxytryptamine receptor 1A	IDA	12441358	PubMed	PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=1930705|UniProtKB=P61264	Syntaxin-1B	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MOUSE|MGI=MGI=2444552|UniProtKB=Q8BFZ3	Beta-actin-like protein 2	IDA	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00056	VEGF signaling pathway	P01423	p38MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00226	Delta/Serrate	DROME|FlyBase=FBgn0000463|UniProtKB=P10041	Neurogenic locus protein delta	ISS			PTHR24044:SF320	DELTA-LIKE PROTEIN 4
P00056	VEGF signaling pathway	P01417	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	3449797	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01093	AChE	HUMAN|HGNC=983|UniProtKB=P06276	Cholinesterase	IC			PTHR43918:SF5	CHOLINESTERASE
P00021	FGF signaling pathway	P00642	MEK1-2	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IGI	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=3595|UniProtKB=Q14517	Protocadherin Fat 1	IDA	8120095	PubMed	PTHR24026:SF42	PROTOCADHERIN FAT 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00462	Casein kinase II	MONDO|Ensembl=ENSMODG00000014080|UniProtKB=F6R511	Uncharacterized protein (Fragment)	ISS	10617630	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00053	T cell activation	P01322	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	IGI	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00012	Cadherin signaling pathway	P00470	F-actin	MOUSE|MGI=MGI=87909|UniProtKB=P62737	Actin, aortic smooth muscle	IC	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=12776|UniProtKB=O96014	Protein Wnt-11	IDA	11266476	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00025	Hedgehog signaling pathway	P00682	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	IDA	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00642	MEK1-2	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00053	T cell activation	P01312	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00056	VEGF signaling pathway	P01417	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P04393	Ras Pathway	P04546	GSK3	PANTR|Ensembl=ENSPTRG00000011049|UniProtKB=H2QGF9	Glycogen synthase kinase 3 alpha	ISS	14698990	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00011	Blood coagulation	P00453	FXIII	PANTR|Ensembl=ENSPTRG00000001806|UniProtKB=H2Q0U3	Uncharacterized protein	ISS	9961357	gi	PTHR19325:SF314	COAGULATION FACTOR XIII B CHAIN
P02738	De novo purine biosynthesis	P02908	Phosphoribosylamine glycine ligase	MACMU|Ensembl=ENSMMUG00000022702|UniProtKB=F7GSL0	Uncharacterized protein	ISS			PTHR10520:SF10	TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00013	Cell cycle	P00480	Proteasome	CANLF|Ensembl=ENSCAFG00000016267|UniProtKB=E2QUY7	Uncharacterized protein	ISS	4506229	gi	PTHR10758:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3
P05730	Endogenous cannabinoid signaling	P05746	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00560	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	RAT|RGD=619965|UniProtKB=P26769	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P05913	Enkephalin release	P05974	G-Protein (i)	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	IC	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DROME|FlyBase=FBgn0261854|UniProtKB=A1Z9X0	Atypical protein kinase C	ISS	15572354	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	MOUSE|MGI=MGI=894315|UniProtKB=Q99JI6	Ras-related protein Rap-1b	ISS	10476970	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00034	Integrin signalling pathway	P00936	PI3K	CAEEL|WormBase=WBGene00006932|UniProtKB=Q9TXI7	Phosphatidylinositol 3-kinase catalytic subunit type 3	IPI	21924698	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00021	FGF signaling pathway	P00629	PP2A	PANTR|Ensembl=ENSPTRG00000003853|UniProtKB=H2Q411	Protein phosphatase 2, regulatory subunit B', beta	ISS	96161994	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	10540223	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00054	Toll receptor signaling pathway	P01367	MKK3	MACMU|Ensembl=ENSMMUG00000010904|UniProtKB=F7GLY5	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P05730	Endogenous cannabinoid signaling	P05751	Galpha	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00059	p53 pathway	P01486	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	RAT|RGD=3425|UniProtKB=P97887	Presenilin-1	IDA	12736250	PubMed	PTHR10202:SF18	PRESENILIN-1
P02788	Xanthine and guanine salvage pathway	P03249	Guanine deaminase	NEUCR|Gene=NCU09621|UniProtKB=Q1K8M4	Guanine deaminase	ISS			PTHR11271:SF38	SUBFAMILY NOT NAMED
P00059	p53 pathway	P04626	GADD45	MOUSE|MGI=MGI=107799|UniProtKB=P48316	Growth arrest and DNA damage-inducible protein GADD45 alpha	IDA	10097101	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01152	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	8270251	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05915	Opioid proenkephalin pathway	P05994	G-protein	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	ISS	12655147	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00996	STAT	MONDO|Ensembl=ENSMODG00000014836|UniProtKB=F7D2D3	Signal transducer and activator of transcription	ISS	95236292	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00036	Interleukin signaling pathway	P00967	c-fos	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	TAS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000025373|UniProtKB=F6ZZG9	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00624	14-3-3	SCHMA|EnsemblGenome=Smp_009760|UniProtKB=G4LUI9	14-3-3 protein, putative	ISS	96123403	PubMed	PTHR18860:SF13	14-3-3 PROTEIN ZETA
P00020	FAS signaling pathway	P00600	PARP	HUMAN|HGNC=271|UniProtKB=Q9UKK3	Poly [ADP-ribose] polymerase 4	TAS	12101391	PubMed	PTHR10338:SF127	POLY  ADP-RIBOSE  POLYMERASE 4
P00056	VEGF signaling pathway	P01425	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02763	Peptidoglycan biosynthesis	P03087	Glutamate racemase	DEIRA|EnsemblGenome=DR_1586|UniProtKB=Q9RU10	Glutamate racemase	ISS			PTHR21198:SF2	GLUTAMATE RACEMASE
P04392	P53 pathway feedback loops 1	P04539	p53	HUMAN|HGNC=11998|UniProtKB=P04637	Cellular tumor antigen p53	TAS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	IGI	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00057	Wnt signaling pathway	P01428	Frizzled	HUMAN|HGNC=4045|UniProtKB=O75084	Frizzled-7	IDA	11212302	PubMed	PTHR11309:SF31	FRIZZLED-7
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IDA			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P02730	Asparagine and aspartate biosynthesis	P02853	Asparagine synthetase	CAEEL|WormBase=WBGene00003816|UniProtKB=O16924	Asparagine synthetase	ISS			PTHR11772:SF35	ASPARAGINE SYNTHETASE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04393	Ras Pathway	P04570	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00773	Duo	MONDO|Ensembl=ENSMODG00000018350|UniProtKB=F6VPX9	Uncharacterized protein	ISS	9285789	PubMed	PTHR22826:SF49	KALIRIN
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00006	Apoptosis signaling pathway	P00258	Bik	HUMAN|HGNC=1051|UniProtKB=Q13323	Bcl-2-interacting killer	IDA	11884414	PubMed	PTHR15018:SF1	BCL-2-INTERACTING KILLER
P00059	p53 pathway	P04609	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	7565716	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00036	Interleukin signaling pathway	P00975	RasGAP	HUMAN|HGNC=9871|UniProtKB=P20936	Ras GTPase-activating protein 1	IC	11847220	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00057	Wnt signaling pathway	P01428	Frizzled	MOUSE|MGI=MGI=108474|UniProtKB=Q61089	Frizzled-6	IDA	8717036	PubMed	PTHR11309:SF75	FRIZZLED-6
P02723	Adenine and hypoxanthine salvage pathway	P02809	Xanthine dehydrogenase	RAT|RGD=62043|UniProtKB=P22985	Xanthine dehydrogenase/oxidase	ISS	12969896	PubMed	PTHR11908:SF80	XANTHINE DEHYDROGENASE/OXIDASE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ENTHI|EnsemblGenome=EHI_107290|UniProtKB=B1N2P0	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	IC	15313841	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	THEKO|EnsemblGenome=TK0260|UniProtKB=O93744	Aspartate aminotransferase	ISS			PTHR43795:SF24	SUBFAMILY NOT NAMED
P00008	Axon guidance mediated by Slit/Robo	P00344	Netrin	MACMU|Ensembl=ENSMMUG00000009397|UniProtKB=F7HEU6	Uncharacterized protein	ISS	11356879	PubMed	PTHR10574:SF365	NETRIN-1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	HUMAN|HGNC=16257|UniProtKB=Q9H4B7	Tubulin beta-1 chain	ISS	9454836	PubMed	PTHR11588:SF112	TUBULIN BETA-1 CHAIN
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	PANTR|Ensembl=ENSPTRG00000009871|UniProtKB=H2QE95	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	TAKRU|Ensembl=ENSTRUG00000010005|UniProtKB=H2TKG8	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01179	PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P06959	CCKR signaling map	P07212	p85	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	RCA	15530849	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	RCA	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	TAS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	CHICK|Ensembl=ENSGALG00000003820|UniProtKB=E1C8Y3	Actin-related protein 2/3 complex subunit 3	ISS	12473693	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00045	Notch signaling pathway	P01113	Pen-2	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	ISS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DANRE|ZFIN=ZDB-GENE-041001-104|UniProtKB=Q5TZD4	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	MACMU|Ensembl=ENSMMUG00000014334|UniProtKB=F7CYY6	Uncharacterized protein	ISS	2137198	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00053	T cell activation	P01324	rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00047	PDGF signaling pathway	P01169	Vav	HUMAN|HGNC=12658|UniProtKB=P52735	Guanine nucleotide exchange factor VAV2	ISS	14623913	PubMed	PTHR22826:SF95	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00046	Oxidative stress response	P01124	Myc	TAKRU|Ensembl=ENSTRUG00000000102|UniProtKB=H2RJA9	Signal transducer and activator of transcription	ISS			PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00629	PP2A	DICDI|dictyBase=DDB_G0272116|UniProtKB=Q9Y0B7	Serine/threonine-protein phosphatase 4 catalytic subunit	ISS			PTHR11668:SF22	SERINE/THREONINE-PROTEIN PHOSPHATASE 4 CATALYTIC SUBUNIT
P00021	FGF signaling pathway	P00643	Raf-1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00047	PDGF signaling pathway	P01172	c-Myc	ARATH|TAIR=AT2G14045|UniProtKB=Q8GW13	At2g14045	ISS	15094771	PubMed	PTHR13168:SF0	C-MYC-BINDING PROTEIN
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00629	PP2A	XENTR|Xenbase=XB-GENE-957526|UniProtKB=K9J7P6	Uncharacterized protein	ISS	11007767	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	IDA			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00029	Huntington disease	P00775	Rac	MOUSE|MGI=MGI=1931553|UniProtKB=Q8R527	Rho-related GTP-binding protein RhoQ	ISS	12932731	PubMed	PTHR24072:SF13	RHO-RELATED GTP-BINDING PROTEIN RHOQ
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CAEBR|Gene=CBG18715|UniProtKB=A8XTZ1	Phosphoinositide phospholipase C	ISS			PTHR10336:SF91	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00010	B cell activation	P00402	Jnk	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00052	TGF-beta signaling pathway	P01275	P38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	TAS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	IC	1333286	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00049	Parkinson disease	P01211	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9836512	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00011	Blood coagulation	P00406	Fibrinogen	CHICK|Ensembl=ENSGALG00000009268|UniProtKB=E1BV78	Uncharacterized protein	ISS	3641556	gi	PTHR19143:SF338	FIBRINOGEN GAMMA CHAIN
P04393	Ras Pathway	P04572	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04553	PAK	CHICK|Ensembl=ENSGALG00000008058|UniProtKB=F1N8W8	Uncharacterized protein	ISS	11259591	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00010	B cell activation	P00376	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01204	GPCR	MOUSE|MGI=MGI=97793|UniProtKB=P35375	Prostaglandin E2 receptor EP1 subtype	IC	14607241	PubMed	PTHR11866:SF3	PROSTAGLANDIN E2 RECEPTOR EP1 SUBTYPE
P05912	Dopamine receptor mediated signaling pathway	P05966	EPB41	PANTR|Ensembl=ENSPTRG00000000442|UniProtKB=H2R0C4	Uncharacterized protein	ISS	12181426	PubMed	PTHR23280:SF12	PROTEIN 4.1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00011	Blood coagulation	P00416	Prothrombin	MOUSE|MGI=MGI=88380|UniProtKB=P19221	Prothrombin	ISS	12621076	gi	PTHR24254:SF10	PROTHROMBIN
P02787	Vitamin B6 metabolism	P03244	Pyridoxal kinase	RAT|RGD=1566085|UniProtKB=D3Z8P5	Protein RGD1566085	ISS	20344886	gi	PTHR10534:SF2	PYRIDOXAL KINASE
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	9094314	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00583	cPLA2	CHICK|Ensembl=ENSGALG00000005065|UniProtKB=P49147	Cytosolic phospholipase A2	IGI	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00018	EGF receptor signaling pathway	P00543	ERK1-2	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00005	Angiogenesis	P00227	PLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	IDA	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MACMU|Ensembl=ENSMMUG00000009341|UniProtKB=F6UA54	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00011	Blood coagulation	P00406	Fibrinogen	CHICK|Gene=FGA|UniProtKB=P14448	Fibrinogen alpha chain	ISS	1706798	gi	PTHR19143:SF232	FIBRINOGEN ALPHA CHAIN
P00038	JAK/STAT signaling pathway	P01030	SOCS	PANTR|Ensembl=ENSPTRG00000007765|UniProtKB=H2QAK6	Suppressor of cytokine signaling 1	ISS			PTHR44621:SF2	SUPPRESSOR OF CYTOKINE SIGNALING 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P02723	Adenine and hypoxanthine salvage pathway	P02807	Deoxyadenosine deaminase	CAEEL|WormBase=WBGene00016630|UniProtKB=Q18599	ACEtyl-CoA Regulator	ISS			PTHR21432:SF19	ACETYL-COA REGULATOR
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	HUMAN|HGNC=6694|UniProtKB=P98164	Low-density lipoprotein receptor-related protein 2	IDA	11907044	PubMed	PTHR44025:SF5	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2
P00006	Apoptosis signaling pathway	P00260	AKT	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	12086862	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MONDO|Ensembl=ENSMODG00000018204|UniProtKB=F6PGX6	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00018	EGF receptor signaling pathway	P00541	Spry	HUMAN|HGNC=11269|UniProtKB=O43609	Protein sprouty homolog 1	ISS	98117253	PubMed	PTHR12365:SF10	PROTEIN SPROUTY HOMOLOG 1
P06664	Gonadotropin-releasing hormone receptor pathway	G06890	Glut1	MOUSE|MGI=MGI=95755|UniProtKB=P17809	Solute carrier family 2, facilitated glucose transporter member 1	RCA			PTHR23503:SF51	SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 1
P00057	Wnt signaling pathway	P01443	Phospholipase C	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	RAT|RGD=1359485|UniProtKB=Q5U302	Catenin (Cadherin associated protein), alpha 1	ISS	9362521	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P02723	Adenine and hypoxanthine salvage pathway	P02807	Deoxyadenosine deaminase	MOUSE|MGI=MGI=1923144|UniProtKB=Q80SY6	Adenosine deaminase-like protein	ISS			PTHR11409:SF42	ADENOSINE DEAMINASE-LIKE PROTEIN
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	RAT|RGD=68385|UniProtKB=D4A055	Calcium channel, voltage-dependent, beta 4 subunit, isoform CRA_b	IC			PTHR11824:SF7	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01444	Wnt	MACMU|Ensembl=ENSMMUG00000017345|UniProtKB=F7H9C0	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00018	EGF receptor signaling pathway	P00540	MKK3,6	CHICK|Ensembl=ENSGALG00000004735|UniProtKB=F1NHE1	Uncharacterized protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00019	Endothelin signaling pathway	P00582	COX-2	PANTR|Ensembl=ENSPTRG00000001786|UniProtKB=H2Q0S9	Prostaglandin-endoperoxide synthase 2 (Prostaglandin G/H synthase and cyclooxygenase)	ISS	11861541	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P05731	GABA-B receptor II signaling	P05760	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05734	Synaptic vesicle trafficking	P05778	SNAP-25	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02729	Ascorbate degradation	P02852	L-xylulose-5-phosphate-3-epimerase	LEPIN|EnsemblGenome=LA_2394|UniProtKB=Q8F3K8	Ribulose-phosphate 3-epimerase	ISS			PTHR11749:SF3	RIBULOSE-PHOSPHATE 3-EPIMERASE
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1170702	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00047	PDGF signaling pathway	P01154	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P04398	p53 pathway feedback loops 2	P04668	p53	DANRE|ZFIN=ZDB-GENE-990415-270|UniProtKB=P79734	Cellular tumor antigen p53	TAS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT1G01560|UniProtKB=Q9LMM5	Mitogen-activated protein kinase 11	IDA	9836510	gi	PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000013316|UniProtKB=H2QK23	Uncharacterized protein	ISS	12181435	PubMed	PTHR24229:SF52	SOMATOSTATIN RECEPTOR TYPE 4
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04578	Rho	CANLF|Ensembl=ENSCAFG00000013413|UniProtKB=E2RMM5	Uncharacterized protein	ISS	10556059	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00047	PDGF signaling pathway	P01173	STAT	BOVIN|Gene=STAT3|UniProtKB=P61635	Signal transducer and activator of transcription 3	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00030	Hypoxia response via HIF activation	P00814	P300	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	DANRE|ZFIN=ZDB-GENE-070524-2|UniProtKB=B6E506	Dopamine receptor D1	ISS			PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00018	EGF receptor signaling pathway	P00562	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00049	Parkinson disease	P01238	14-3-3	CANAL|CGD=CAL0000198341|UniProtKB=O42766	14-3-3 protein homolog	IDA	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	TAS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00047	PDGF signaling pathway	P01142	p90RSK	RAT|RGD=1307277|UniProtKB=D3ZSB7	Ribosomal protein S6 kinase	ISS	9792677	PubMed	PTHR24351:SF41	RIBOSOMAL PROTEIN S6 KINASE ALPHA-4
P00018	EGF receptor signaling pathway	P00564	Rac	DICPU|Gene=DICPUDRAFT_55703|UniProtKB=F0ZN94	Putative uncharacterized protein racC	ISS	12932731	PubMed	PTHR24072:SF117	RHO-RELATED PROTEIN RACC
P00036	Interleukin signaling pathway	P00975	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	8270251	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04393	Ras Pathway	P04570	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	1170702	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00049	Parkinson disease	P01236	Casein kinase II	DICPU|Gene=DICPUDRAFT_26270|UniProtKB=F0Z8A7	Protein serine/threonine kinase	ISS	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01171	PLCgamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	TAS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	9332390	PubMed	PTHR10202:SF13	PRESENILIN-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MACMU|Ensembl=ENSMMUG00000022111|UniProtKB=F7H7W3	Ribosomal protein S6 kinase	ISS	7688567	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	TAS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000010143|UniProtKB=F6QXA9	Uncharacterized protein	ISS	10644715	PubMed	PTHR24356:SF175	SERINE/THREONINE-PROTEIN KINASE N3
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1354946|UniProtKB=Q61532	Mitogen-activated protein kinase 6	IDA	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00029	Huntington disease	P00780	Microtubule	CANLF|Ensembl=ENSCAFG00000018634|UniProtKB=E2RFV2	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF253	TUBULIN BETA-4A CHAIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05938	RhoA	XENTR|Xenbase=XB-GENE-489222|UniProtKB=Q28GJ8	Ras homolog gene family, member A	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00037	Ionotropic glutamate receptor pathway	P01026	KA	CANLF|Ensembl=ENSCAFG00000003333|UniProtKB=F1PWT6	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00591	PLCbeta	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00005	Angiogenesis	P00204	PLD	MACMU|Ensembl=ENSMMUG00000005666|UniProtKB=F6VWY6	Uncharacterized protein	ISS	15030398	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P00048	PI3 kinase pathway	P01202	p85	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00559	MEK1-2	YEAST|SGD=S000005757|UniProtKB=P32490	MAP kinase kinase MKK1/SSP32	ISS			PTHR24361:SF351	MAP KINASE KINASE MKK1/SSP32-RELATED
P00034	Integrin signalling pathway	P00922	Collagen	PANTR|Ensembl=ENSPTRG00000012992|UniProtKB=H2QJJ5	Uncharacterized protein	ISS	10778855	PubMed	PTHR24023:SF435	COLLAGEN ALPHA-3 IV  CHAIN
P00018	EGF receptor signaling pathway	P00539	14-3-3	BOVIN|Gene=YWHAB|UniProtKB=P68250	14-3-3 protein beta/alpha	IGI	91108808	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00029	Huntington disease	P00780	Microtubule	THAPS|Gene=Thaps8069|UniProtKB=B8C8B4	Tubulin beta	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Ensembl=ENSBTAG00000008059|UniProtKB=P41984	Muscarinic acetylcholine receptor M3	IDA			PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00010	B cell activation	P00368	vav	PANTR|Ensembl=ENSPTRG00000010378|UniProtKB=H2QF58	Uncharacterized protein	ISS	10661401	PubMed	PTHR22826:SF112	PROTO-ONCOGENE VAV
P00047	PDGF signaling pathway	P01140	ELK	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	ISS	14670631	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00007	Axon guidance mediated by semaphorins	P00340	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P05916	Opioid prodynorphin pathway	P06002	G-protein	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00012	Cadherin signaling pathway	P00470	F-actin	ANOGA|EnsemblGenome=AGAP001676|UniProtKB=Q7PXZ8	AGAP001676-PA	IC	14684598	PubMed	PTHR11937:SF368	ACTIN, INDIRECT FLIGHT MUSCLE
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CAEEL|WormBase=WBGene00009595|UniProtKB=Q7JMS5	Uncharacterized protein	TAS	10823891	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	TAS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MACMU|Ensembl=ENSMMUG00000009778|UniProtKB=F6Y1M7	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF385	MYOSIN-2
P00059	p53 pathway	G04694	p110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00054	Toll receptor signaling pathway	P01368	MKK2	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00005	Angiogenesis	P00243	Raf	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00034	Integrin signalling pathway	P00948	Rho	PANTR|Ensembl=ENSPTRG00000014922|UniProtKB=H2QML4	Uncharacterized protein	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=99842|UniProtKB=Q02284	5-hydroxytryptamine receptor 1F	IDA	11701344	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00053	T cell activation	P01322	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IGI	9516481	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	DROME|FlyBase=FBgn0030087|UniProtKB=Q9W391	Probable phosphorylase b kinase regulatory subunit alpha	IDA	10487978	PubMed	PTHR10749:SF7	PHOSPHORYLASE B KINASE REGULATORY SUBUNIT ALPHA-RELATED
P00049	Parkinson disease	P01242	Casein kinase I	RAT|RGD=621404|UniProtKB=Q62761	Casein kinase I isoform gamma-1	ISS	10617630	PubMed	PTHR11909:SF156	CASEIN KINASE I ISOFORM GAMMA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01177	P110ACT	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	G01529	Proline oxidase	EMENI|EnsemblGenome=CADANIAG00008376|UniProtKB=Q5BCJ9	Proline oxidase [Source:UniProtKB/TrEMBLAcc:Q9P8H9]	NAS			PTHR13914:SF0	PROLINE DEHYDROGENASE 1, MITOCHONDRIAL
P00034	Integrin signalling pathway	P00951	Jnk	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00019	Endothelin signaling pathway	P00586	Gq	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04393	Ras Pathway	P04567	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MOUSE|MGI=MGI=1915021|UniProtKB=Q9CPW4	Actin-related protein 2/3 complex subunit 5	ISS	9230079	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000021808|UniProtKB=Q9MZL3	Voltage-dependent L-type calcium channel subunit beta-3	IC			PTHR11824:SF8	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-3
P00018	EGF receptor signaling pathway	P00559	MEK1-2	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00034	Integrin signalling pathway	P00924	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02721	ATP synthesis	P02791	F1 alpha	CANLF|Ensembl=ENSCAFG00000017648|UniProtKB=E2RNG2	ATP synthase subunit alpha	ISS	2527557	PubMed	PTHR43089:SF3	ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00010	B cell activation	P00375	Calmodulin	ORYSJ|EnsemblGenome=OS05G0491100|UniProtKB=Q6F332	Calmodulin-2	ISS	9753452	PubMed	PTHR23050:SF324	CALMODULIN-2-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04393	Ras Pathway	P04546	GSK3	CANLF|Ensembl=ENSCAFG00000004882|UniProtKB=F1PAE3	Uncharacterized protein	ISS	14698990	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00021	FGF signaling pathway	P00624	14-3-3	MOUSE|MGI=MGI=891963|UniProtKB=P68254	14-3-3 protein theta	IDA	9211421	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00021	FGF signaling pathway	P00635	FRS2	MONDO|Ensembl=ENSMODG00000020378|UniProtKB=F7F6D5	Uncharacterized protein	ISS	10464310	PubMed	PTHR21258:SF40	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2
P00036	Interleukin signaling pathway	P00976	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04393	Ras Pathway	P04561	SRF	MOUSE|MGI=MGI=106658|UniProtKB=Q9JM73	Serum response factor	IDA	15170389	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00057	Wnt signaling pathway	P01443	Phospholipase C	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	MOUSE|MGI=MGI=1920431|UniProtKB=Q8K120	Nuclear factor of activated T-cells, cytoplasmic 4	ISS	9133421	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=1748|UniProtKB=P12830	Cadherin-1	IDA	12834808	PubMed	PTHR24027:SF319	CADHERIN-1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=17175|UniProtKB=Q9P212	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	15611108	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P04393	Ras Pathway	P04542	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	12471242	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00936	PI3K	DROME|FlyBase=FBgn0015278|UniProtKB=Q7K3H0	LD28067p	IPI	8662856	PubMed	PTHR10048:SF64	LD28067P
P00006	Apoptosis signaling pathway	P00302	ATF	MOUSE|MGI=MGI=105121|UniProtKB=O35451	Cyclic AMP-dependent transcription factor ATF-6 beta	ISS	11390664	PubMed	PTHR22952:SF168	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-6 BETA
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	SCHPO|PomBase=SPBC3H7.15|UniProtKB=P40235	Casein kinase I homolog hhp1	IDA	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	RAT|RGD=2087|UniProtKB=P51647	Retinal dehydrogenase 1	IC			PTHR11699:SF140	RETINAL DEHYDROGENASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=3234|UniProtKB=P33535	Mu-type opioid receptor	IDA	11259498	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00045	Notch signaling pathway	P01103	Next	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=620023|UniProtKB=P10980	Muscarinic acetylcholine receptor M2	IDA	91373358	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00010	B cell activation	P00391	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	MOUSE|MGI=MGI=99460|UniProtKB=Q61982	Neurogenic locus notch homolog protein 3	IDA	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00010	B cell activation	P00371	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01153	GSK3	ARATH|TAIR=AT3G05840|UniProtKB=P43289	Shaggy-related protein kinase gamma	ISS	12615961	PubMed	PTHR24057:SF13	SHAGGY-RELATED PROTEIN KINASE ALPHA-RELATED
P00052	TGF-beta signaling pathway	P01284	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02753	Methionine biosynthesis	P03024	Homocysteine transmethylase	DROME|FlyBase=FBgn0032727|UniProtKB=Q9VJ31	CG10623 protein	ISS			PTHR21091:SF123	FI01821P
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05730	Endogenous cannabinoid signaling	P05751	Galpha	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00059	p53 pathway	P04609	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=1759|UniProtKB=P19022	Cadherin-2	ISS	8120095	PubMed	PTHR24027:SF79	CADHERIN-2
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	CHICK|Ensembl=ENSGALG00000008339|UniProtKB=E1BQS9	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00005	Angiogenesis	P00238	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P05915	Opioid proenkephalin pathway	P05994	G-protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	ISS	8170357	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00029	Huntington disease	P00805	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00047	PDGF signaling pathway	P01161	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02741	Flavin biosynthesis	P02935	GTP cyclohydrolase	NEUCR|Gene=NCU01449|UniProtKB=V5ILK6	GTP cyclohydrolase II	ISS			PTHR21327:SF16	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DICDI|dictyBase=DDB_G0283907|UniProtKB=P34099	cAMP-dependent protein kinase catalytic subunit	IC	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	ISS	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00113	Erb-B4 transmembrane fragment	MOUSE|MGI=MGI=104771|UniProtKB=Q61527	Receptor tyrosine-protein kinase erbB-4	ISS	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CAEEL|WormBase=WBGene00006765|UniProtKB=P48181	Acetylcholine receptor subunit beta-type unc-29	IC	22213672	PubMed	PTHR18945:SF471	ACETYLCHOLINE RECEPTOR SUBUNIT BETA-TYPE UNC-29
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MONDO|Ensembl=ENSMODG00000001807|UniProtKB=F6Y7R9	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00030	Hypoxia response via HIF activation	P00814	P300	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00029	Huntington disease	P00776	c-Jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	3136397	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=98961|UniProtKB=P24383	Protein Wnt-7a	TAS	11266476	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000011757|UniProtKB=Q9XT97	Presenilin-1	IDA	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06798	PKCe/theta	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	RCA	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00048	PI3 kinase pathway	P01188	Gbetagamma	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P02738	De novo purine biosynthesis	P02889	dGDP kinase	CAEBR|Gene=CBG02247|UniProtKB=A8WS68	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	IXOSC|EnsemblGenome=ISCW021482|UniProtKB=B7Q717	Beta-tubulin, putative (Fragment)	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00048	PI3 kinase pathway	P01192	p110	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00052	TGF-beta signaling pathway	P01275	P38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00013	Cell cycle	P00485	Cdk2	PANTR|Ensembl=ENSPTRG00000006741|UniProtKB=H2Q8Y1	Cyclin-dependent kinase 2 interacting protein	ISS	12477932	PubMed	PTHR15827:SF2	CYCLIN-DEPENDENT KINASE 2-INTERACTING PROTEIN
P00034	Integrin signalling pathway	P00920	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IPI	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00047	PDGF signaling pathway	P01153	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04398	p53 pathway feedback loops 2	P04657	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	TAS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00018	EGF receptor signaling pathway	P00540	MKK3,6	MONDO|Ensembl=ENSMODG00000001404|UniProtKB=F7BD74	Uncharacterized protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	RAT|RGD=620138|UniProtKB=G3V830	Interleukin 10 receptor, alpha	ISS	11594787	PubMed	PTHR20859:SF43	INTERLEUKIN-10 RECEPTOR SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00223	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01451	Galpha	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IDA	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01408	Akt/PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=12781|UniProtKB=Q93097	Protein Wnt-2b	TAS	12549854	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00057	Wnt signaling pathway	P01471	alpha-catenin	CHICK|Gene=CTNNA2|UniProtKB=P30997	Catenin alpha-2	IDA	1638632	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P00045	Notch signaling pathway	P01104	Serrate	BOVIN|Ensembl=ENSBTAG00000012817|UniProtKB=E1BDN7	Delta-like protein	ISS	10551863	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	ORNAN|Ensembl=ENSOANG00000000467|UniProtKB=F7F4P1	Uncharacterized protein	ISS	10391901	PubMed	PTHR15936:SF2	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-13
P00018	EGF receptor signaling pathway	P00547	PP2A	DICPU|Gene=DICPUDRAFT_91511|UniProtKB=F0ZDJ1	Serine/threonine-protein phosphatase	ISS	10452519	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00465	TCF/LEF	MONDO|Ensembl=ENSMODG00000015573|UniProtKB=F7AIP6	Uncharacterized protein (Fragment)	ISS	9118222	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00034	Integrin signalling pathway	P00941	Integrin alpha	PANTR|Ensembl=ENSPTRG00000005040|UniProtKB=H2Q644	Uncharacterized protein	ISS	3487386	PubMed	PTHR23220:SF3	INTEGRIN ALPHA-5
P04393	Ras Pathway	P04544	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12186904	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P06664	Gonadotropin-releasing hormone receptor pathway	P06798	PKCe/theta	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	RCA	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IGI	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000003399|UniProtKB=H2Q383	Phosphoinositide-3-kinase, class 2, alpha polypeptide	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P02738	De novo purine biosynthesis	P02902	ADP reductase	MYCTU|EnsemblGenome=Rv3048c|UniProtKB=P9WH71	Ribonucleoside-diphosphate reductase subunit beta nrdF2	ISS			PTHR23409:SF32	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT BETA
P00029	Huntington disease	P00807	Actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00029	Huntington disease	P00794	Hippi	MOUSE|MGI=MGI=1921166|UniProtKB=Q8BXG3	Intraflagellar transport protein 57 homolog	IDA	11889126	PubMed	PTHR16011:SF0	INTRAFLAGELLAR TRANSPORT PROTEIN 57 HOMOLOG
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000005917|UniProtKB=F6QM53	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	HUMAN|HGNC=7574|UniProtKB=Q9Y623	Myosin-4	IEP	89264452	PubMed	PTHR13140:SF681	MYOSIN-4
P00005	Angiogenesis	P00208	MEKK1	MACMU|Ensembl=ENSMMUG00000012387|UniProtKB=F7EB20	Uncharacterized protein	ISS	12049732	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CAEBR|Gene=CBG02167|UniProtKB=A8WS37	Protein CBG02167	ISS	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	DROME|FlyBase=FBgn0024846|UniProtKB=O61443	Mitogen-activated protein kinase 14B	ISS	10851062	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00008	Axon guidance mediated by Slit/Robo	P00352	DCC	HUMAN|HGNC=2701|UniProtKB=P43146	Netrin receptor DCC	ISS	12810718	PubMed	PTHR44146:SF3	NETRIN RECEPTOR DCC
P04397	p53 pathway by glucose deprivation	P04640	p53	DANRE|ZFIN=ZDB-GENE-030819-1|UniProtKB=E9QG65	Uncharacterized protein	TAS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IC	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CHICK|Ensembl=ENSGALG00000006638|UniProtKB=R4GGL9	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00053	T cell activation	P01332	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00274	JNK	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	ISS	10851062	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00053	T cell activation	P01312	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04395	Vasopressin synthesis	P04593	Glycopeptide	MOUSE|MGI=MGI=97453|UniProtKB=P35454	Oxytocin-neurophysin 1	IC	3768139	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	IDA	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CAEEL|WormBase=WBGene00004036|UniProtKB=G5EFI8	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01275	P38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	TAS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00049	Parkinson disease	P01242	Casein kinase I	HUMAN|HGNC=2451|UniProtKB=P48729	Casein kinase I isoform alpha	IDA	11437445	PubMed	PTHR11909:SF84	CASEIN KINASE I ISOFORM ALPHA
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P02754	Methylcitrate cycle	P03028	Aconitase	RHOBA|EnsemblGenome=RB2114|UniProtKB=Q7UWD2	Aconitate hydratase	ISS			PTHR11670:SF1	ACONITATE HYDRATASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=3023|UniProtKB=P14416	D(2) dopamine receptor	IDA	11861492	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00047	PDGF signaling pathway	P01152	RasGAP	HUMAN|HGNC=9871|UniProtKB=P20936	Ras GTPase-activating protein 1	ISS	11847220	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00059	p53 pathway	P04633	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01318	PKC-theta	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02750	Lipoate_biosynthesis	P03004	Lipoate synthase	MYCTU|EnsemblGenome=Rv2218|UniProtKB=P9WK91	Lipoyl synthase	ISS			PTHR10949:SF0	LIPOYL SYNTHASE, MITOCHONDRIAL
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00624	14-3-3	PANTR|Ensembl=ENSPTRG00000030723|UniProtKB=H2RC87	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF14	14-3-3 PROTEIN SIGMA
P00053	T cell activation	P01332	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00025	Hedgehog signaling pathway	P00692	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02788	Xanthine and guanine salvage pathway	P03247	Xanthine phosphoribosyl transferase	PSEAE|EnsemblGenome=PA4645|UniProtKB=Q9HVE7	Probable purine/pyrimidine phosphoribosyl transferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	HUMAN|HGNC=7176|UniProtKB=P14780	Matrix metalloproteinase-9	TAS	12834808	PubMed	PTHR10201:SF30	MATRIX METALLOPROTEINASE-9
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00029	Huntington disease	P00790	beta-Tubulin	DROME|FlyBase=FBgn0052396|UniProtKB=Q9VRX3	Probable tubulin beta chain CG32396	TAS	9454836	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	CHICK|Ensembl=ENSGALG00000001334|UniProtKB=F1NLV4	Uncharacterized protein	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	ISS	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	MOUSE|MGI=MGI=88397|UniProtKB=Q9ERZ4	Muscarinic acetylcholine receptor M2	ISS	10069496	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00048	PI3 kinase pathway	P01192	p110	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00807	Actin	MOUSE|MGI=MGI=87905|UniProtKB=P68033	Actin, alpha cardiac muscle 1	IDA	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00007	Axon guidance mediated by semaphorins	P00331	PAK	HUMAN|HGNC=8590|UniProtKB=Q13153	Serine/threonine-protein kinase PAK 1	ISS	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00005	Angiogenesis	P00238	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P04393	Ras Pathway	P04570	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00912	Arp2/3	BOVIN|Gene=ARPC5|UniProtKB=Q3SYX9	Actin-related protein 2/3 complex subunit 5	IPI	12473693	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	HUMAN|HGNC=4403|UniProtKB=P61952	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	IC			PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00010	B cell activation	P00376	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00029	Huntington disease	P00805	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00006	Apoptosis signaling pathway	P00318	PKCs	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	ISS	11535291	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00006	Apoptosis signaling pathway	P00274	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	ISS	10514528	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	1764995	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P02783	Tryptophan biosynthesis	P03210	Indole-3-glycerol phosphate synthase	METAC|EnsemblGenome=MA_2992|UniProtKB=Q8TLP2	Indole-3-glycerol phosphate synthase	ISS			PTHR22854:SF2	TRYPTOPHAN BIOSYNTHESIS PROTEIN TRPCF
P00021	FGF signaling pathway	P00645	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00006	Apoptosis signaling pathway	P00269	MAPK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	ISS	11707292	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P02744	Fructose galactose metabolism	P02964	Hexose 1-P uridyltransferase	BOVIN|Ensembl=ENSBTAG00000015807|UniProtKB=Q58CX1	Galactose-1-phosphate uridylyltransferase	ISS	1427861	PubMed	PTHR11943:SF1	GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00056	VEGF signaling pathway	P01415	MAPKAPK2/3	BOVIN|Ensembl=ENSBTAG00000016532|UniProtKB=Q3SYZ2	MAP kinase-activated protein kinase 3	ISS	11157753	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00916	Ras	CHICK|Ensembl=ENSGALG00000006885|UniProtKB=P08642	GTPase HRas	ISS	87226391	PubMed	PTHR24070:SF385	GTPASE HRAS
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	ORYSJ|EnsemblGenome=OS07G0492000|UniProtKB=Q07661	Nucleoside diphosphate kinase 1	ISS			PTHR11349:SF66	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00632	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MOUSE|MGI=MGI=87890|UniProtKB=P09690	Acetylcholine receptor subunit beta	IC	22213672	PubMed	PTHR18945:SF477	ACETYLCHOLINE RECEPTOR SUBUNIT BETA
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00004	Alzheimer disease-presenilin pathway	P00111	C99	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	RCA	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00010	B cell activation	P00383	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00019	Endothelin signaling pathway	P00580	ET-RA/B	DANRE|ZFIN=ZDB-GENE-980526-16|UniProtKB=Q9DGM2	Endothelin receptor B	IGI	20525582	PubMed	PTHR24243:SF30	ENDOTHELIN B RECEPTOR
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	PANTR|Gene=HTR1F|UniProtKB=Q9N2D9	5-hydroxytryptamine receptor 1F (Fragment)	ISS	12181435	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P02751	Lysine biosynthesis	P03011	N-succinyldiaminopimelate  aminotransferase	BACSU|EnsemblGenome=BSU11220|UniProtKB=P36839	Acetylornithine aminotransferase	IDA			PTHR11986:SF79	ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL
P00004	Alzheimer disease-presenilin pathway	P00114	actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g210933|UniProtKB=A7SEA7	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=17175|UniProtKB=Q9P212	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	7822322	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04545	Sec5	MOUSE|MGI=MGI=1913732|UniProtKB=Q9D4H1	Exocyst complex component 2	ISS			PTHR13043:SF1	EXOCYST COMPLEX COMPONENT 2
P00053	T cell activation	P01319	PAK	CHICK|Ensembl=ENSGALG00000000681|UniProtKB=E1C3P6	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00029	Huntington disease	P00786	ARF	BOVIN|Ensembl=ENSBTAG00000009366|UniProtKB=A4IFP7	ARF5 protein	ISS	12932731	PubMed	PTHR11711:SF308	ADP-RIBOSYLATION FACTOR 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_125401|UniProtKB=C3ZTX6	Putative uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MOUSE|MGI=MGI=87902|UniProtKB=P68134	Actin, alpha skeletal muscle	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00019	Endothelin signaling pathway	P00572	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00052	TGF-beta signaling pathway	P01276	Co-Smads	MACMU|Ensembl=ENSMMUG00000018334|UniProtKB=F7H894	Mothers against decapentaplegic homolog	ISS	10693808	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P05913	Enkephalin release	P05971	CREB	MONDO|Ensembl=ENSMODG00000015970|UniProtKB=F7FD05	Uncharacterized protein	ISS	11390664	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P05916	Opioid prodynorphin pathway	P05998	Kappa Receptor	CANLF|Ensembl=ENSCAFG00000032542|UniProtKB=J9P639	Uncharacterized protein	ISS	11259487	PubMed	PTHR24229:SF1	KAPPA-TYPE OPIOID RECEPTOR
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IDA	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	PANTR|Ensembl=ENSPTRG00000020439|UniProtKB=H2QWG4	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF43	GROWTH/DIFFERENTIATION FACTOR 6
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	DROME|FlyBase=FBgn0001965|UniProtKB=P26675	Protein son of sevenless	ISS	476780	gi	PTHR23113:SF99	PROTEIN SON OF SEVENLESS
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	NEUCR|EnsemblGenome=EFNCRG00000006002|UniProtKB=Q7SBR2	Phosphoinositide phospholipase C	ISS			PTHR10336:SF82	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00990	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8972|UniProtKB=O00750	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00036	Interleukin signaling pathway	P00973	PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00238	Ras	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	IC	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00029	Huntington disease	P00780	Microtubule	DICDI|dictyBase=DDB_G0269196|UniProtKB=P32256	Tubulin beta chain	IDA	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04398	p53 pathway feedback loops 2	P04657	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	PANTR|Ensembl=ENSPTRG00000016548|UniProtKB=H2QQC5	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00018	EGF receptor signaling pathway	P00551	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IGI	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00011	Blood coagulation	P00458	GP IIIa	MOUSE|MGI=MGI=96612|UniProtKB=O54890	Integrin beta-3	ISS	386150	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00047	PDGF signaling pathway	P01171	PLCgamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IC	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04546	GSK3	MOUSE|MGI=MGI=2152453|UniProtKB=Q2NL51	Glycogen synthase kinase-3 alpha	ISS	14698990	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00059	p53 pathway	P04630	PP2A	ANOGA|EnsemblGenome=AGAP010172|UniProtKB=Q7PD38	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01192	p110	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	BOVIN|Ensembl=ENSBTAG00000020957|UniProtKB=F1MGM1	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF126	FRIZZLED-5
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DROME|FlyBase=FBgn0000489|UniProtKB=P16912	Protein kinase DC2	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02738	De novo purine biosynthesis	P02893	ATP reductase	METAC|EnsemblGenome=MA_0072|UniProtKB=Q8TUJ5	Anaerobic ribonucleoside-triphosphate reductase	ISS			PTHR21075:SF0	ANAEROBIC RIBONUCLEOSIDE-TRIPHOSPHATE REDUCTASE
P00018	EGF receptor signaling pathway	P00564	Rac	DICDI|dictyBase=DDB_G0269178|UniProtKB=Q9GPS0	Rho-related protein racG	ISS			PTHR24072:SF192	CDC42 HOMOLOG
P02772	Pyruvate metabolism	P03140	Pyruvate Carboxylase	PANTR|Ensembl=ENSPTRG00000023133|UniProtKB=H2R399	Pyruvate carboxylase	ISS	200246	gi	PTHR43778:SF2	PYRUVATE CARBOXYLASE, MITOCHONDRIAL
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00034	Integrin signalling pathway	P00931	Integrin beta	RAT|RGD=1303119|UniProtKB=Q6AYF4	Integrin beta-6	ISS	3487386	PubMed	PTHR10082:SF11	INTEGRIN BETA-6
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00046	Oxidative stress response	P01131	MKP5	PANTR|Ensembl=ENSPTRG00000014988|UniProtKB=H2QMQ8	Dual specificity protein phosphatase	ISS			PTHR10159:SF305	DUAL SPECIFICITY PROTEIN PHOSPHATASE 7
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05943	GRK2	HUMAN|HGNC=289|UniProtKB=P25098	Beta-adrenergic receptor kinase 1	RCA	8288567	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P00018	EGF receptor signaling pathway	P00548	RKIP	DROME|FlyBase=FBgn0037432|UniProtKB=Q9VI08	GH28351p	ISS			PTHR11362:SF28	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P00034	Integrin signalling pathway	P00907	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00274	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	TAKRU|Ensembl=ENSTRUG00000016144|UniProtKB=H2UWE3	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00048	PI3 kinase pathway	P01192	p110	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05994	G-protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00049	Parkinson disease	P01226	CDCrel-1	BOVIN|Gene=SEPT2|UniProtKB=Q2NKY7	Septin-2	ISS			PTHR18884:SF67	SEPTIN-2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	MOUSE|MGI=MGI=95698|UniProtKB=P47856	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1	ISS			PTHR10937:SF2	GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE  ISOMERIZING  1
P00053	T cell activation	P01322	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	IGI	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04398	p53 pathway feedback loops 2	P04668	p53	RAT|RGD=3889|UniProtKB=P10361	Cellular tumor antigen p53	TAS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	IPI	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00036	Interleukin signaling pathway	P00996	STAT	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	ORNAN|Ensembl=ENSOANG00000006811|UniProtKB=F6WBD5	Uncharacterized protein	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00054	Toll receptor signaling pathway	P01361	TBK1	RAT|RGD=1588588|UniProtKB=D4A7D3	Protein Tbk1	ISS			PTHR22969:SF14	SERINE/THREONINE-PROTEIN KINASE TBK1
P00020	FAS signaling pathway	P00611	Gelsolin	RAT|RGD=1311724|UniProtKB=Q6AYC4	Macrophage-capping protein	ISS	9323209	PubMed	PTHR11977:SF13	MACROPHAGE-CAPPING PROTEIN
P00020	FAS signaling pathway	P00596	Caspase6	CHICK|Ensembl=ENSGALG00000012186|UniProtKB=F1NEL6	Uncharacterized protein	IGI	10770929	PubMed	PTHR10454:SF164	CASPASE-6
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95817|UniProtKB=Q8BMF5	Glutamate receptor ionotropic, kainate 4	ISS	12871085	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00029	Huntington disease	P00794	Hippi	RAT|RGD=1305947|UniProtKB=D4A1V1	Intraflagellar transport 57 homolog (Chlamydomonas) (Predicted)	ISS	11788820	PubMed	PTHR16011:SF0	INTRAFLAGELLAR TRANSPORT PROTEIN 57 HOMOLOG
P05730	Endogenous cannabinoid signaling	P05746	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00029	Huntington disease	P00807	Actin	RAT|RGD=2025|UniProtKB=P68136	Actin, alpha skeletal muscle	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	TAS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000000843|UniProtKB=H2QZN8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00053	T cell activation	P01331	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00507	Rho	MOUSE|MGI=MGI=1931551|UniProtKB=Q9ER71	Rho-related GTP-binding protein RhoJ	ISS	12932731	PubMed	PTHR24072:SF17	RHO-RELATED GTP-BINDING PROTEIN RHOJ
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	DANRE|ZFIN=ZDB-GENE-051202-1|UniProtKB=E7F101	Uncharacterized protein	ISS	11554554	PubMed	PTHR44391:SF2	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00568	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	3045562	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00059	p53 pathway	P04609	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	14526383	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00046	Oxidative stress response	P01126	ATF2	BOVIN|Ensembl=ENSBTAG00000002295|UniProtKB=F1N177	Uncharacterized protein	ISS	7875593	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00046	Oxidative stress response	P01137	MNK1/2	MACMU|Ensembl=ENSMMUG00000011265|UniProtKB=F6WP09	Uncharacterized protein	ISS	11463832	PubMed	PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	MACMU|Ensembl=ENSMMUG00000001060|UniProtKB=F6QN17	Uncharacterized protein	ISS	15226293	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00053	T cell activation	P01309	fos	CANLF|Ensembl=ENSCAFG00000017040|UniProtKB=E2QYK5	Uncharacterized protein	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00018	EGF receptor signaling pathway	P00543	ERK1-2	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00034	Integrin signalling pathway	P00907	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	IDA	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IGI	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANAL|CGD=CAL0068551|UniProtKB=Q5AAR9	Phosphatidylinositol 3-kinase	TAS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00034	Integrin signalling pathway	P00944	Actin	BOVIN|Gene=ACTG2|UniProtKB=Q5E9B5	Actin, gamma-enteric smooth muscle	ISS	3487386	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00053	T cell activation	P01300	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00254	GTPase	PANTR|Ensembl=ENSPTRG00000001112|UniProtKB=H2PZP2	Ras homolog gene family, member C	ISS	12090470	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00021	FGF signaling pathway	P00633	Ras	DICPU|Gene=DICPUDRAFT_57324|UniProtKB=F0ZVH9	Putative uncharacterized protein rasS	ISS	94119591	PubMed	PTHR24070:SF380	RAS-LIKE PROTEIN RASS
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00047	PDGF signaling pathway	P01160	IP3 receptor	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00010	B cell activation	P00384	p38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IDA	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00274	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00029	Huntington disease	G01535	PIG3	STRCO|Gene=CAB61611|UniProtKB=Q9RJX1	Putative oxidoreductase	TAS	12932731	PubMed	PTHR43677:SF4	QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05760	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000021900|UniProtKB=F1MFK1	Uncharacterized protein	ISS	11554554	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00017	DNA replication	P00527	Histones	CRYNJ|EnsemblGenome=CNJ02540|UniProtKB=P0CO04	Histone H3	ISS	12413958	PubMed	PTHR11426:SF47	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01275	P38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	TAS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	NEUCR|EnsemblGenome=EFNCRG00000003547|UniProtKB=Q1K615	Beta-apo-4'-carotenal oxygenase	IC			PTHR43570:SF11	SUBFAMILY NOT NAMED
P00053	T cell activation	P01336	Jnk	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=1560161|UniProtKB=D3ZTI3	Protein Cdh24	ISS	8120095	PubMed	PTHR24027:SF272	CADHERIN-24
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	MOUSE|MGI=MGI=96607|UniProtKB=P05555	Integrin alpha-M	IDA	12060491	PubMed	PTHR23220:SF120	INTEGRIN ALPHA-M
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	MOUSE|MGI=MGI=109284|UniProtKB=Q61144	Presenilin-2	TAS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=1305811|UniProtKB=F2Z3R8	Protein Pcdhb15	ISS	8120095	PubMed	PTHR24028:SF69	PROTOCADHERIN BETA-7
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00010	B cell activation	P00391	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02788	Xanthine and guanine salvage pathway	P03247	Xanthine phosphoribosyl transferase	PANTR|Ensembl=ENSPTRG00000002366|UniProtKB=H2R333	Phosphoribosyl transferase domain containing 1	ISS			PTHR43340:SF5	PHOSPHORIBOSYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	IC	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	TAS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00052	TGF-beta signaling pathway	P01284	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00034	Integrin signalling pathway	P00925	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	RAT|RGD=2343|UniProtKB=P08483	Muscarinic acetylcholine receptor M3	IDA	8100450	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00047	PDGF signaling pathway	P01151	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01236	Casein kinase II	HUMAN|HGNC=2458|UniProtKB=Q8NEV1	Casein kinase II subunit alpha 3	IDA	10806215	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P04393	Ras Pathway	P04558	p38	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	IDA	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00005	Angiogenesis	P00223	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	ARATH|TAIR=AT2G19470|UniProtKB=Q9ZUP4	At2g19470	IDA	11437445	PubMed	PTHR11909:SF298	CASEIN KINASE 1-LIKE PROTEIN 12-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	MYCTU|EnsemblGenome=Rv2763c|UniProtKB=P9WNX1	Dihydrofolate reductase	ISS			PTHR22778:SF16	DIHYDROFOLATE REDUCTASE
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IDA	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00053	T cell activation	P01331	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00048	PI3 kinase pathway	P01190	PDK1 ACT	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	IDA	11256888	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00056	VEGF signaling pathway	P01408	Akt/PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00053	T cell activation	P01330	IKK	BOVIN|Ensembl=ENSBTAG00000007599|UniProtKB=Q95KV0	Inhibitor of nuclear factor kappa-B kinase subunit beta	IGI	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00021	FGF signaling pathway	P00642	MEK1-2	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00640	PI3K	CANAL|CGD=CAL0068551|UniProtKB=Q5AAR9	Phosphatidylinositol 3-kinase	IGI	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	8836152	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IDA	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00059	p53 pathway	P04613	B99	MOUSE|MGI=MGI=1352755|UniProtKB=Q8R080	G2 and S phase-expressed protein 1	ISS	20127556	gi	PTHR21584:SF10	G2 AND S PHASE-EXPRESSED PROTEIN 1
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	RAT|RGD=1549703|UniProtKB=P82808	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1	ISS			PTHR10937:SF2	GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE  ISOMERIZING  1
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=69424|UniProtKB=Q99P84	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	12176394	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P05916	Opioid prodynorphin pathway	P06002	G-protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	IDA	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00056	VEGF signaling pathway	P01417	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	XENTR|Xenbase=XB-GENE-494200|UniProtKB=F7CS79	Uncharacterized protein	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00020	FAS signaling pathway	P00597	Apaf1	HUMAN|HGNC=576|UniProtKB=O14727	Apoptotic protease-activating factor 1	ISS	10364241	PubMed	PTHR22845:SF5	APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00022	General transcription by RNA polymerase I	P00657	TBP	HUMAN|HGNC=11588|UniProtKB=P20226	TATA-box-binding protein	ISS	11988536	PubMed	PTHR10126:SF20	TATA-BOX-BINDING PROTEIN
P04393	Ras Pathway	P04556	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00060	Ubiquitin proteasome pathway	P01491	E2	YEAST|SGD=S000002499|UniProtKB=P52490	Ubiquitin-conjugating enzyme E2 13	ISS			PTHR43902:SF2	UBIQUITIN-CONJUGATING ENZYME E2 N
P00018	EGF receptor signaling pathway	P00552	Ras	DROME|FlyBase=FBgn0003205|UniProtKB=P08646	Ras-like protein 1	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00046	Oxidative stress response	P01121	MKK3/6	HUMAN|HGNC=6843|UniProtKB=P46734	Dual specificity mitogen-activated protein kinase kinase 3	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00034	Integrin signalling pathway	P00927	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	RAT|RGD=620966|UniProtKB=Q62925	Mitogen-activated protein kinase kinase kinase 1	IGI	8643568	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P04393	Ras Pathway	P04558	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05913	Enkephalin release	P05974	G-Protein (i)	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	IC	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00011	Blood coagulation	P00429	PN2	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	ISS	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04393	Ras Pathway	P04563	Ets	MACMU|Ensembl=ENSMMUG00000020706|UniProtKB=F6PU72	Uncharacterized protein	ISS	3060801	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06755	CBP	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	RCA	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	PANTR|Ensembl=ENSPTRG00000020956|UniProtKB=H2QXA8	Aldehyde dehydrogenase 1 family, member B1	ISS			PTHR11699:SF207	ALDEHYDE DEHYDROGENASE X, MITOCHONDRIAL
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014262|UniProtKB=F7BYS8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00013	Cell cycle	P00480	Proteasome	PANTR|Ensembl=ENSPTRG00000009109|UniProtKB=G2HF36	26S proteasome non-ATPase regulatory subunit 3	ISS	2568889	PubMed	PTHR10758:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00018	EGF receptor signaling pathway	P00564	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	HUMAN|HGNC=9857|UniProtKB=P61224	Ras-related protein Rap-1b	IDA	10476970	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00059	p53 pathway	P01480	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04397	p53 pathway by glucose deprivation	P04641	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00047	PDGF signaling pathway	P01154	Ras	TAKRU|Ensembl=ENSTRUG00000018273|UniProtKB=H2VC15	Uncharacterized protein	ISS			PTHR24073:SF581	SUBFAMILY NOT NAMED
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00021	FGF signaling pathway	P00633	Ras	BOVIN|Ensembl=ENSBTAG00000009778|UniProtKB=E1BMX0	Uncharacterized protein	ISS	9869449	PubMed	PTHR24070:SF186	GTPASE KRAS
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	15621031	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02738	De novo purine biosynthesis	P02889	dGDP kinase	SCHPO|PomBase=SPAC806.07|UniProtKB=P49740	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P02748	Isoleucine biosynthesis	P02995	Threonine dehydratase	NEUCR|EnsemblGenome=EFNCRG00000003325|UniProtKB=Q1K7R8	Threonine dehydratase catabolic	ISS			PTHR43050:SF1	SERINE RACEMASE
P00013	Cell cycle	P00480	Proteasome	BOVIN|Ensembl=ENSBTAG00000018897|UniProtKB=Q2KI42	26S proteasome non-ATPase regulatory subunit 11	ISS	97227943	PubMed	PTHR10678:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	BOVIN|Ensembl=ENSBTAG00000047202|UniProtKB=G3N3K3	Uncharacterized protein	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P05918	p38 MAPK pathway	P06026	MEKK4	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS	12878610	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00011	Blood coagulation	P00457	Thrombomodulin	MOUSE|MGI=MGI=98736|UniProtKB=P15306	Thrombomodulin	ISS	6678339	gi	PTHR24036:SF5	THROMBOMODULIN
P05916	Opioid prodynorphin pathway	P05999	provasopressin	HUMAN|HGNC=8528|UniProtKB=P01178	Oxytocin-neurophysin 1	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DROME|FlyBase=FBgn0261854|UniProtKB=A1Z9X0	Atypical protein kinase C	ISS	2837282	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00048	PI3 kinase pathway	P01177	P110ACT	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06847	JNK1/2	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	RCA	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00005	Angiogenesis	P00190	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01001	KA4	RAT|RGD=2734|UniProtKB=Q01812	Glutamate receptor ionotropic, kainate 4	IC	12871085	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00367	NFAT	BOVIN|Ensembl=ENSBTAG00000018270|UniProtKB=F1MGR9	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00025	Hedgehog signaling pathway	P00682	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00053	T cell activation	P01307	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	IPI	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00029	Huntington disease	P00774	Dynein complex	PANTR|Ensembl=ENSPTRG00000019422|UniProtKB=H2QUY9	Uncharacterized protein	ISS	9454836	PubMed	PTHR12442:SF34	CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00021	FGF signaling pathway	P00647	SHP2	PANTR|Ensembl=ENSPTRG00000042397|UniProtKB=H2RIH8	Tyrosine-protein phosphatase non-receptor type	ISS	14525967	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00005	Angiogenesis	P00223	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01181	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00029	Huntington disease	P00807	Actin	PHYIT|EnsemblGenome=PITG_15078|UniProtKB=D0NRL5	Actin-like protein	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	PANTR|Ensembl=ENSPTRG00000004718|UniProtKB=H2Q5I0	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00025	Hedgehog signaling pathway	P00691	CBP	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01457	GBeta	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00057	Wnt signaling pathway	P01437	TCF	MOUSE|MGI=MGI=1202879|UniProtKB=Q924A0	Transcription factor 7-like 2	IDA	11266476	PubMed	PTHR10373:SF32	TRANSCRIPTION FACTOR 7-LIKE 2
P05730	Endogenous cannabinoid signaling	P05746	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00045	Notch signaling pathway	P01119	NIct	HUMAN|HGNC=7884|UniProtKB=Q99466	Neurogenic locus notch homolog protein 4	ISS	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	PANTR|Ensembl=ENSPTRG00000004079|UniProtKB=H2R1Z2	Uncharacterized protein	ISS	11742073	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00047	PDGF signaling pathway	P01173	STAT	MACMU|Ensembl=ENSMMUG00000010707|UniProtKB=F7G8G5	Signal transducer and activator of transcription	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04456	ProCRF (Pro Corticotropin-Releasing Factor)	MOUSE|MGI=MGI=88496|UniProtKB=Q8CIT0	Corticoliberin	ISS	122560	OMIM	PTHR15035:SF9	CORTICOLIBERIN
P00025	Hedgehog signaling pathway	P00682	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	HUMAN|HGNC=7850|UniProtKB=P22392	Nucleoside diphosphate kinase B	ISS			PTHR11349:SF57	NUCLEOSIDE DIPHOSPHATE KINASE B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01219	SAPK	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	ISS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00018	EGF receptor signaling pathway	P00539	14-3-3	BOVIN|Ensembl=ENSBTAG00000000236|UniProtKB=P63103	14-3-3 protein zeta/delta	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P05731	GABA-B receptor II signaling	P05752	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00005	Angiogenesis	P00255	Notch	MOUSE|MGI=MGI=107471|UniProtKB=P31695	Neurogenic locus notch homolog protein 4	ISS	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00644	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02754	Methylcitrate cycle	P03028	Aconitase	BOVIN|Gene=ACO1|UniProtKB=Q0VCU1	Cytoplasmic aconitate hydratase	ISS			PTHR11670:SF32	CYTOPLASMIC ACONITATE HYDRATASE
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DICDI|dictyBase=DDB_G0283907|UniProtKB=P34099	cAMP-dependent protein kinase catalytic subunit	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04397	p53 pathway by glucose deprivation	P04641	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02749	Leucine biosynthesis	P02999	2-Isopropylmalate synthase	GLOVI|EnsemblGenome=BAC90231|UniProtKB=Q7NI93	2-isopropylmalate synthase	ISS			PTHR10277:SF9	2-ISOPROPYLMALATE SYNTHASE 1, CHLOROPLASTIC-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	BOVIN|Ensembl=ENSBTAG00000007661|UniProtKB=F1MMC7	Uncharacterized protein	ISS			PTHR13140:SF288	UNCONVENTIONAL MYOSIN-IF
P00005	Angiogenesis	P00192	PAR	HUMAN|HGNC=3537|UniProtKB=P25116	Proteinase-activated receptor 1	RCA			PTHR24232:SF20	PROTEINASE-ACTIVATED RECEPTOR 1
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	DROME|FlyBase=FBgn0004598|UniProtKB=P30432	Furin-like protease 2	IDA	10956649	PubMed	PTHR42884:SF2	FURIN-LIKE PROTEASE 2
P00015	Circadian clock system	G01499	per	DANRE|ZFIN=ZDB-GENE-000804-1|UniProtKB=F1RDZ4	Uncharacterized protein	ISS			PTHR11269:SF13	PERIOD CIRCADIAN PROTEIN HOMOLOG 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MACMU|Ensembl=ENSMMUG00000009600|UniProtKB=F7AC65	Uncharacterized protein	ISS	12623444	PubMed	PTHR11920:SF291	ADENYLATE CYCLASE TYPE 3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	IC	2372396	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00025	Hedgehog signaling pathway	P00682	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00059	p53 pathway	P04630	PP2A	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	MACMU|Ensembl=ENSMMUG00000014817|UniProtKB=F6VXD8	Uncharacterized protein	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P02776	Serine glycine biosynthesis	P03160	Phosphoglycerate dehydrogenase	SYNY3|Gene=BAA18060|UniProtKB=P73990	D-isomer specific 2-hydroxyacid dehydrogenase family	ISS			PTHR10996:SF203	2-HYDROXYACID DEHYDROGENASE YGL185C-RELATED
P00005	Angiogenesis	P00254	GTPase	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000024633|UniProtKB=F1MBU9	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IC	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02728	Arginine biosynthesis	P02847	N-actetylornithine deacetylase	SCHPO|PomBase=SPCC757.05c|UniProtKB=O74916	Peptidase M20 domain-containing protein C757.05c	ISS			PTHR43808:SF8	SUBFAMILY NOT NAMED
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DICPU|Gene=DICPUDRAFT_93216|UniProtKB=F1A421	Guanine nucleotide-binding protein subunit beta	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00029	Huntington disease	P00807	Actin	TAKRU|Ensembl=ENSTRUG00000005494|UniProtKB=P53483	Actin, alpha anomalous	IDA	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00059	p53 pathway	P04609	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P06959	CCKR signaling map	P07139	MAP3K11	HUMAN|HGNC=6850|UniProtKB=Q16584	Mitogen-activated protein kinase kinase kinase 11	RCA	20150185	PubMed	PTHR43997:SF1	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 11
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	IC	http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00029	Huntington disease	P00780	Microtubule	MOUSE|MGI=MGI=107812|UniProtKB=P99024	Tubulin beta-5 chain	IDA	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	MACMU|Ensembl=ENSMMUG00000003857|UniProtKB=F7HA84	Nucleoside diphosphate kinase	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	ISS	8700226	PubMed	PTHR10048:SF14	PI-3 KINASE
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=69280|UniProtKB=Q9Z1Y3	Cadherin-2	IDA	8120095	PubMed	PTHR24027:SF79	CADHERIN-2
P02755	Methylmalonyl pathway	P03034	Methylmalonyl-CoA mutase	DEIRA|EnsemblGenome=DR_2032|UniProtKB=Q9RSU1	Methylmalonyl-CoA mutase	ISS			PTHR23408:SF19	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	CHICK|Ensembl=ENSGALG00000006426|UniProtKB=E1BS97	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00046	Oxidative stress response	P01135	p38	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	TAS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	CHICK|Ensembl=ENSGALG00000011905|UniProtKB=F1NHT7	Uncharacterized protein	TAS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00021	FGF signaling pathway	P00629	PP2A	HUMAN|HGNC=9306|UniProtKB=Q9Y2T4	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform	ISS	7918404	PubMed	PTHR11871:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B GAMMA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ORNAN|Ensembl=ENSOANG00000000460|UniProtKB=F7F4W9	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00052	TGF-beta signaling pathway	P01292	RSmads	RAT|RGD=3030|UniProtKB=P97588	Mothers against decapentaplegic homolog 1	TAS	9395284	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00056	VEGF signaling pathway	P01411	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	87226391	PubMed	PTHR24070:SF385	GTPASE HRAS
P04393	Ras Pathway	P04542	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT2G43790|UniProtKB=Q39026	Mitogen-activated protein kinase 6	ISS	12787066	PubMed	PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P04393	Ras Pathway	P04547	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00036	Interleukin signaling pathway	P00987	SRF	BOVIN|Ensembl=ENSBTAG00000012777|UniProtKB=E1BJP4	Uncharacterized protein	ISS	15647354	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00006	Apoptosis signaling pathway	P00260	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00644	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00021	FGF signaling pathway	P00644	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IGI	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00048	PI3 kinase pathway	P01188	Gbetagamma	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00005	Angiogenesis	P00238	Ras	DICPU|Gene=DICPUDRAFT_92731|UniProtKB=F0ZWE6	Putative uncharacterized protein rasG	ISS			PTHR24070:SF282	RAS GTPASE-RELATED
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	YEAST|SGD=S000005762|UniProtKB=P07807	Dihydrofolate reductase	ISS			PTHR11548:SF3	DIHYDROFOLATE REDUCTASE
P00005	Angiogenesis	P00199	JNKK1	MONDO|Ensembl=ENSMODG00000008266|UniProtKB=F6Z879	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P02775	Salvage pyrimidine ribonucleotides	P03150	Uridine kinase	MOUSE|MGI=MGI=1931744|UniProtKB=Q99PM9	Uridine-cytidine kinase 2	ISS			PTHR10285:SF70	URIDINE-CYTIDINE KINASE 2
P00054	Toll receptor signaling pathway	P01358	ERK1	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00006	Apoptosis signaling pathway	P00269	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	PANTR|Gene=CHRM5|UniProtKB=Q5IS53	Muscarinic acetylcholine receptor M5	ISS	12181435	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	IDA	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00021	FGF signaling pathway	P00630	RKIP	MACMU|Ensembl=ENSMMUG00000005098|UniProtKB=F5CI18	Phosphatidylethanolamine-binding protein	ISS	94311839	PubMed	PTHR11362:SF28	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IDA	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00021	FGF signaling pathway	P00627	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	97102671	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	HUMAN|HGNC=4586|UniProtKB=Q13224	Glutamate receptor ionotropic, NMDA 2B	IC	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=11334|UniProtKB=P35346	Somatostatin receptor type 5	IDA	12562507	PubMed	PTHR24229:SF20	SOMATOSTATIN RECEPTOR TYPE 5
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00057	Wnt signaling pathway	P01452	NFAT	MACMU|Ensembl=ENSMMUG00000022596|UniProtKB=F6Z7T2	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF5	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00029	Huntington disease	G01530	HTT	CANLF|Ensembl=ENSCAFG00000014682|UniProtKB=F1P7Y7	Uncharacterized protein	ISS	9462744	PubMed	PTHR10170:SF10	HUNTINGTIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IDA	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04393	Ras Pathway	P04565	MKK4/7	CHICK|Ensembl=ENSGALG00000001001|UniProtKB=F1P3T1	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00021	FGF signaling pathway	P00642	MEK1-2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	CANLF|Ensembl=ENSCAFG00000015905|UniProtKB=E2QUH6	Uncharacterized protein	ISS	4757780	gi	PTHR11792:SF20	BETA-ARRESTIN-2
P00003	Alzheimer disease-amyloid secretase pathway	P00101	BACE-1	MONDO|Ensembl=ENSMODG00000013692|UniProtKB=F6QP52	Uncharacterized protein	ISS	10956649	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00004	Alzheimer disease-presenilin pathway	P00141	Membrane metalloprotease	MACMU|Ensembl=ENSMMUG00000007052|UniProtKB=F7F147	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF25	MATRIX METALLOPROTEINASE-15
P00053	T cell activation	P01306	Ras	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	IDA	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00019	Endothelin signaling pathway	P00586	Gq	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IDA	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00385	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00018	EGF receptor signaling pathway	P00545	JNK1-3	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS			PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05731	GABA-B receptor II signaling	P05755	Gbeta	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00049	Parkinson disease	P01242	Casein kinase I	MONDO|Ensembl=ENSMODG00000009937|UniProtKB=F6R812	Uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00048	PI3 kinase pathway	P01185	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00030	Hypoxia response via HIF activation	P00821	Prolyl Hydroxylase	BOVIN|Ensembl=ENSBTAG00000008172|UniProtKB=A7MBA0	EGLN3 protein	ISS	12912907	PubMed	PTHR12907:SF5	EGL NINE HOMOLOG 3
P00047	PDGF signaling pathway	P01151	PKB	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IGI	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00036	Interleukin signaling pathway	P00981	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04375	5HT3 type receptor mediated signaling pathway	P04425	K+ channel	MONDO|Ensembl=ENSMODG00000015769|UniProtKB=F6ZSC2	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	DICDI|dictyBase=DDB_G0283537|UniProtKB=P32254	Ras-like protein rasS	ISS	94119591	PubMed	PTHR24070:SF380	RAS-LIKE PROTEIN RASS
P00053	T cell activation	P01307	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00036	Interleukin signaling pathway	P00986	eNOS	MACMU|Ensembl=ENSMMUG00000020437|UniProtKB=F6WEB2	Nitric oxide synthase	ISS	9837777	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P05913	Enkephalin release	P05977	G-Protein (s)	MONDO|Ensembl=ENSMODG00000016595|UniProtKB=F6ZDB2	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IDA	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04397	p53 pathway by glucose deprivation	P04641	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00737	Rap1GAP	MOUSE|MGI=MGI=2139309|UniProtKB=Q3V0G7	GTPase-activating Rap/Ran-GAP domain-like protein 3	ISS	10419452	PubMed	PTHR15711:SF31	GTPASE-ACTIVATING RAP/RAN-GAP DOMAIN-LIKE PROTEIN 3
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00018	EGF receptor signaling pathway	P00556	PLCgamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IGI	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00006	Apoptosis signaling pathway	P00321	HSP70	CAEBR|Gene=CBG00457|UniProtKB=A8WN50	Protein CBR-HSP-1	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00053	T cell activation	P01306	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MOUSE|MGI=MGI=99674|UniProtKB=Q91WF3	Adenylate cyclase type 4	IDA	9870949	PubMed	PTHR11920:SF286	ADENYLATE CYCLASE TYPE 4
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DANRE|ZFIN=ZDB-GENE-030131-172|UniProtKB=Q6IQR3	Actin, alpha, cardiac muscle 1a	IEP	14684598	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00810	GAPDH	CAEEL|WormBase=WBGene00001685|UniProtKB=P17330	Glyceraldehyde-3-phosphate dehydrogenase 3	IPI			PTHR10836:SF52	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	DANRE|ZFIN=ZDB-GENE-020125-4|UniProtKB=F1QKT1	Uncharacterized protein	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	RCA	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00056	VEGF signaling pathway	P01425	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	89186920	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	DANRE|ZFIN=ZDB-GENE-030131-5541|UniProtKB=Q7ZYX7	Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog)	ISS			PTHR10540:SF7	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	PANTR|Ensembl=ENSPTRG00000016800|UniProtKB=H2QQS3	Solute carrier family 1 (Glial high affinity glutamate transporter), member 3	ISS	96032356	PubMed	PTHR11958:SF24	EXCITATORY AMINO ACID TRANSPORTER 1
P04397	p53 pathway by glucose deprivation	P04640	p53	PANTR|Ensembl=ENSPTRG00000015733|UniProtKB=H2QNY5	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	PANTR|Ensembl=ENSPTRG00000013825|UniProtKB=H2RAK4	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00006	Apoptosis signaling pathway	P00269	MAPK	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=708420|UniProtKB=Q62688	Inactive phospholipase C-like protein 1	TAS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P00034	Integrin signalling pathway	P00925	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000020588|UniProtKB=F7C0E0	Uncharacterized protein	ISS	11880265	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00008	Axon guidance mediated by Slit/Robo	P00355	Rho	CANAL|CGD=CAL0000192659|UniProtKB=O42825	GTP-binding protein RHO1	ISS	11973360	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00021	FGF signaling pathway	P00630	RKIP	DROME|FlyBase=FBgn0037433|UniProtKB=Q9VI09	GH14494p	ISS			PTHR11362:SF75	GH14494P
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00060	Ubiquitin proteasome pathway	P01491	E2	MOUSE|MGI=MGI=2384911|UniProtKB=P61080	Ubiquitin-conjugating enzyme E2 D1	ISS			PTHR24068:SF36	UBIQUITIN-CONJUGATING ENZYME E2 D1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00848	Grb	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8479536	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CANLF|Gene=ADORA2B|UniProtKB=Q6W3F4	Adenosine receptor A2b	ISS			PTHR24246:SF18	ADENOSINE RECEPTOR A2B
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	DANRE|ZFIN=ZDB-GENE-980526-416|UniProtKB=Q92048	Protein Wnt-2	TAS	8717036	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00044	Nicotinic acetylcholine receptor signaling pathway	P01093	AChE	BRAFL|Gene=BRAFLDRAFT_116869|UniProtKB=C3ZD75	Carboxylic ester hydrolase	ISS	86008285	PubMed	PTHR11559:SF356	ACETYLCHOLINESTERASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CANLF|Ensembl=ENSCAFG00000005662|UniProtKB=E2R907	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01407	Erk	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00021	FGF signaling pathway	P00643	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01470	Frodo	XENTR|Xenbase=XB-GENE-478639|UniProtKB=Q66KC9	Dapper 1	ISS	11970895	PubMed	PTHR15919:SF12	DAPPER HOMOLOG 1
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	HALSA|EnsemblGenome=VNG_0006G|UniProtKB=Q9HT00	Glutamine--fructose-6-phosphate aminotransferase [isomerizing]	ISS			PTHR10937:SF0	GH12731P-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT2G18170|UniProtKB=Q39027	Mitogen-activated protein kinase 7	ISS	9836510	gi	PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P00054	Toll receptor signaling pathway	P01368	MKK2	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04398	p53 pathway feedback loops 2	P04654	Rb	PANTR|Ensembl=ENSPTRG00000005864|UniProtKB=H2Q7K0	Retinoblastoma 1	ISS			PTHR13742:SF17	RETINOBLASTOMA-ASSOCIATED PROTEIN
P04397	p53 pathway by glucose deprivation	P04642	Rheb	MACMU|Ensembl=ENSMMUG00000006250|UniProtKB=F7H5C5	GTP-binding protein Rheb	ISS	12842888	PubMed	PTHR24070:SF264	GTP-BINDING PROTEIN RHEB
P00057	Wnt signaling pathway	P01444	Wnt	DANRE|ZFIN=ZDB-GENE-990415-279|UniProtKB=P51029	Protein Wnt-8b	IDA	11266476	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF330	SUBFAMILY NOT NAMED
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	CHICK|Ensembl=ENSGALG00000006426|UniProtKB=E1BS97	Uncharacterized protein	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00016	Cytoskeletal regulation by Rho GTPase	P00519	ROCK	MONDO|Ensembl=ENSMODG00000011938|UniProtKB=F7DDX8	Uncharacterized protein (Fragment)	ISS			PTHR22988:SF28	RHO-ASSOCIATED PROTEIN KINASE 2
P00059	p53 pathway	P01486	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00056	VEGF signaling pathway	P01407	Erk	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00778	NMDA receptor	MONDO|Ensembl=ENSMODG00000018204|UniProtKB=F6PGX6	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	MACMU|Ensembl=ENSMMUG00000020322|UniProtKB=F6WHL1	Fructose-bisphosphate aldolase	ISS	2350361	PubMed	PTHR11627:SF3	FRUCTOSE-BISPHOSPHATE ALDOLASE C
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P02774	Salvage pyrimidine deoxyribonucleotides	P03145	Uracil phosphorylase	THEMA|EnsemblGenome=TM_1653|UniProtKB=Q9S5X9	Pyrimidine-nucleoside phosphorylase	ISS	8824600	PubMed	PTHR10515:SF0	THYMIDINE PHOSPHORYLASE
P00029	Huntington disease	P00812	Caspase 3	MOUSE|MGI=MGI=107739|UniProtKB=P70677	Caspase-3	ISS	9323209	PubMed	PTHR10454:SF198	CASPASE-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000015240|UniProtKB=F6VUY3	Uncharacterized protein	ISS	11431030	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00034	Integrin signalling pathway	P00923	Arf1	XENTR|Xenbase=XB-GENE-961332|UniProtKB=Q5BJ82	ADP-ribosylation factor-like 1	ISS	11752622	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P00020	FAS signaling pathway	P00615	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	MONDO|Ensembl=ENSMODG00000018204|UniProtKB=F6PGX6	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P02762	Pentose phosphate pathway	P03079	Hexokinase	MOUSE|MGI=MGI=1315197|UniProtKB=O08528	Hexokinase-2	RCA			PTHR19443:SF4	HEXOKINASE-2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00010	B cell activation	P00384	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	ISS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00034	Integrin signalling pathway	P00951	Jnk	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	PANTR|Ensembl=ENSPTRG00000009279|UniProtKB=H2QD74	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF34	FRIZZLED-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	TAS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	DROME|FlyBase=FBgn0001991|UniProtKB=Q24270	Voltage-dependent calcium channel type D subunit alpha-1	ISS	15621031	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00211	GSK3beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00019	Endothelin signaling pathway	P00577	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00054	Toll receptor signaling pathway	P01375	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00012	Cadherin signaling pathway	P00470	F-actin	STRPU|EnsemblGenome=SPU_012282|UniProtKB=W4Y969	Uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF369	ACTIN-42A
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DICDI|dictyBase=DDB_G0283907|UniProtKB=P34099	cAMP-dependent protein kinase catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	DROME|FlyBase=FBgn0010341|UniProtKB=P40793	Cdc42 homolog	ISS			PTHR24072:SF192	CDC42 HOMOLOG
P04398	p53 pathway feedback loops 2	P04665	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00628	JNK1-3	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IGI	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00024	Glycolysis	P00679	Aldolase	DROME|FlyBase=FBgn0000064|UniProtKB=P07764	Fructose-bisphosphate aldolase	ISS	96063611	PubMed	PTHR11627:SF20	FRUCTOSE-BISPHOSPHATE ALDOLASE
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	PHYPA|Gene=PHYPADRAFT_146516|UniProtKB=A9TJH4	S-adenosylmethionine synthase	ISS			PTHR11964:SF1	S-ADENOSYLMETHIONINE SYNTHASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	BRAFL|Gene=BRAFLDRAFT_115565|UniProtKB=C3XYD3	Putative uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00056	VEGF signaling pathway	P01415	MAPKAPK2/3	HUMAN|HGNC=6887|UniProtKB=P49137	MAP kinase-activated protein kinase 2	ISS	10779545	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	RAT|RGD=1564914|UniProtKB=D3ZUE4	Protein Socs5	ISS	15032587	PubMed	PTHR44282:SF3	SUPPRESSOR OF CYTOKINE SIGNALING 5
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	BOVIN|Ensembl=ENSBTAG00000026580|UniProtKB=F1MB93	Uncharacterized protein	ISS	11701344	PubMed	PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P00036	Interleukin signaling pathway	P00996	STAT	BOVIN|Gene=STAT3|UniProtKB=P61635	Signal transducer and activator of transcription 3	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	DROME|FlyBase=FBgn0004611|UniProtKB=P25455	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00054	Toll receptor signaling pathway	P01370	TAK1	MONDO|Ensembl=ENSMODG00000018170|UniProtKB=F7CCD5	Uncharacterized protein	ISS	10683140	PubMed	PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P02747	Histidine biosynthesis	P02986	Phosphoribosyl ATP pyrophosphatase	BACTN|EnsemblGenome=BT_1377|UniProtKB=Q8A7Z7	Histidine biosynthesis bifunctional protein HisIE	ISS			PTHR42945:SF1	HISTIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN HISIE, CHLOROPLASTIC
P00019	Endothelin signaling pathway	P00566	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	RAT|RGD=1311985|UniProtKB=B2GV73	Actin-related protein 2/3 complex subunit 3	ISS	9359840	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ORNAN|Ensembl=ENSOANG00000007405|UniProtKB=F7CIV4	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00059	p53 pathway	P04609	PI3K	DROME|FlyBase=FBgn0015278|UniProtKB=Q7K3H0	LD28067p	ISS	14526383	PubMed	PTHR10048:SF64	LD28067P
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00010	B cell activation	P00373	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00059	p53 pathway	G04701	PML	MACMU|Ensembl=ENSMMUG00000002569|UniProtKB=F7HSN6	Uncharacterized protein	ISS	14992722	PubMed	PTHR45211:SF1	PROTEIN PML
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05915	Opioid proenkephalin pathway	P05994	G-protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	ISS	1482697	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	CANLF|Ensembl=ENSCAFG00000005109|UniProtKB=Q3LSL6	C-X-C chemokine receptor type 4	ISS	11943720	PubMed	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	10395542	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	HUMAN|HGNC=2456|UniProtKB=Q9Y6M4	Casein kinase I isoform gamma-3	IDA	11437445	PubMed	PTHR11909:SF151	CASEIN KINASE I ISOFORM GAMMA-3
P00021	FGF signaling pathway	P00643	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	RAT|RGD=621515|UniProtKB=P61954	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	ISS			PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00049	Parkinson disease	P01238	14-3-3	CHICK|Gene_ORFName=RCJMB04_5e12|UniProtKB=Q5F3W6	14-3-3 protein gamma	ISS	91108808	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00037	Ionotropic glutamate receptor pathway	P01021	Vglut	HUMAN|HGNC=16703|UniProtKB=Q9P2U8	Vesicular glutamate transporter 2	ISS	12815758	PubMed	PTHR11662:SF201	VESICULAR GLUTAMATE TRANSPORTER 2
P00011	Blood coagulation	P00418	Fibrin monomer	HUMAN|HGNC=3661|UniProtKB=P02671	Fibrinogen alpha chain	ISS	6575700	PubMed	PTHR19143:SF232	FIBRINOGEN ALPHA CHAIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01072	CHT1	CAEBR|Gene=CBG01811|UniProtKB=A8WQR8	Protein CBR-CHO-1	ISS	12675135	PubMed	PTHR11819:SF12	HIGH-AFFINITY CHOLINE TRANSPORTER 1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P06959	CCKR signaling map	P07165	STAT3	HUMAN|HGNC=11364|UniProtKB=P40763	Signal transducer and activator of transcription 3	RCA	15530849	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00019	Endothelin signaling pathway	P00566	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01457	GBeta	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00010	B cell activation	P00370	NFkappaB	CANLF|Ensembl=ENSCAFG00000010155|UniProtKB=E2RLL2	Uncharacterized protein	ISS	12574369	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00019	Endothelin signaling pathway	P00572	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CHICK|Ensembl=ENSGALG00000027629|UniProtKB=Q5ZJ03	Guanine nucleotide-binding protein subunit gamma	IDA	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00021	FGF signaling pathway	P00632	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00111	C99	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00034	Integrin signalling pathway	P00911	B-Raf	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00029	Huntington disease	P00790	beta-Tubulin	DAPPU|EnsemblGenome=DAPPUDRAFT_302845|UniProtKB=E9GER1	Putative uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	CANLF|Ensembl=ENSCAFG00000016077|UniProtKB=E2QW66	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CAEBR|Gene=CBG18256|UniProtKB=A8XS95	Protein CBR-ACT-5	ISS	11889126	PubMed	PTHR11937:SF352	ACTIN
P00019	Endothelin signaling pathway	P00570	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00049	Parkinson disease	P01238	14-3-3	CHICK|Ensembl=ENSGALG00000004143|UniProtKB=Q5ZLQ6	14-3-3 protein beta/alpha	ISS	1671102	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00021	FGF signaling pathway	P00641	SOS	DICDI|dictyBase=DDB_G0284329|UniProtKB=Q54PQ4	Ras guanine nucleotide exchange factor A	IGI			PTHR23113:SF236	RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR A
P04393	Ras Pathway	P04542	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00029	Huntington disease	P00780	Microtubule	MOUSE|MGI=MGI=107814|UniProtKB=A2AQ07	Tubulin beta-1 chain	IDA	12932731	PubMed	PTHR11588:SF112	TUBULIN BETA-1 CHAIN
P00010	B cell activation	P00386	Calcineurin	MONDO|Ensembl=ENSMODG00000020679|UniProtKB=F7DKU1	Serine/threonine-protein phosphatase	ISS	7532676	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	BOVIN|Ensembl=ENSBTAG00000005464|UniProtKB=E1B9K3	Uncharacterized protein	ISS	10978539	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00021	FGF signaling pathway	P00629	PP2A	YEAST|SGD=S000005540|UniProtKB=P38903	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	ISS			PTHR10257:SF3	PP2A-B', ISOFORM B
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	IDA	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02776	Serine glycine biosynthesis	P03157	Phosphoserine aminotransferase	STRCO|Gene=CAC08322|UniProtKB=Q9F2Y1	Phosphoserine aminotransferase	ISS			PTHR21152:SF24	SUBFAMILY NOT NAMED
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS	88311074	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00057	Wnt signaling pathway	P01428	Frizzled	MOUSE|MGI=MGI=1196625|UniProtKB=O70421	Frizzled-1	IDA	11212302	PubMed	PTHR11309:SF81	FRIZZLED-1
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	PANTR|Ensembl=ENSPTRG00000005448|UniProtKB=H2Q6V8	Serine/threonine-protein phosphatase	ISS	8392016	PubMed	PTHR11668:SF204	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-GAMMA CATALYTIC SUBUNIT
P00046	Oxidative stress response	P01126	ATF2	BOVIN|Ensembl=ENSBTAG00000002295|UniProtKB=F1N177	Uncharacterized protein	ISS	15218628	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00057	Wnt signaling pathway	P01443	Phospholipase C	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04393	Ras Pathway	P04556	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00035	Interferon-gamma signaling pathway	P00960	PTP	CANLF|Ensembl=ENSCAFG00000008894|UniProtKB=F1Q3J6	Tyrosine-protein phosphatase non-receptor type	ISS	7681589	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00036	Interleukin signaling pathway	P00962	ELK	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	IDA	11279280	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00051	TCA cycle	P01266	Pyruvate Dehydrogenase	CHLTR|EnsemblGenome=CT_245|UniProtKB=O84247	Pyruvate dehydrogenase E1 component subunit alpha	ISS	10684935	PubMed	PTHR11516:SF53	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01170	PDGF	RAT|RGD=3282|UniProtKB=P28576	Platelet-derived growth factor subunit A	ISS			PTHR11633:SF3	PLATELET-DERIVED GROWTH FACTOR SUBUNIT A
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00642	MEK1-2	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00560	Raf-1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02759	Pyridoxal-5-phosphate biosynthesis	P03058	Phosphohydroxythreonine aminotransferase	BOVIN|Ensembl=ENSBTAG00000013960|UniProtKB=A6QR28	Phosphoserine aminotransferase	ISS	20886743	gi	PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P00047	PDGF signaling pathway	P01151	PKB	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05918	p38 MAPK pathway	P06029	p38beta	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ENTHI|EnsemblGenome=EHI_107290|UniProtKB=B1N2P0	Actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	IDA	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P02756	N-acetylglucosamine metabolism	P03041	Glucosamine-6-phosphate deaminase	BOVIN|Ensembl=ENSBTAG00000000287|UniProtKB=Q17QL1	Glucosamine-6-phosphate isomerase 2	ISS			PTHR11280:SF9	GLUCOSAMINE-6-PHOSPHATE ISOMERASE 2
P00021	FGF signaling pathway	P00633	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00006	Apoptosis signaling pathway	P00269	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04570	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00023	General transcription regulation	P00660	RNA Polymerase II	CHICK|Ensembl=ENSGALG00000008534|UniProtKB=E1BSD8	Uncharacterized protein	ISS	606023	OMIM	PTHR10917:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MACMU|Ensembl=ENSMMUG00000016049|UniProtKB=Q95JG1	Gonadotropin-releasing hormone II receptor	IDA			PTHR24241:SF116	GONADOTROPIN-RELEASING HORMONE II RECEPTOR-RELATED
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	BOVIN|Ensembl=ENSBTAG00000014674|UniProtKB=P41985	Muscarinic acetylcholine receptor M2	ISS	10069496	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P05912	Dopamine receptor mediated signaling pathway	P05970	TH	MACMU|Ensembl=ENSMMUG00000003912|UniProtKB=F6ZV38	Uncharacterized protein	ISS	12814656	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P04393	Ras Pathway	P04572	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00114	actin	RAT|RGD=1304556|UniProtKB=P63259	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00047	PDGF signaling pathway	P01161	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	3449797	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00023	General transcription regulation	P00658	TBP-associated factors	CAEEL|WormBase=WBGene00006390|UniProtKB=Q7YTH5	TAF (TBP-associated transcription factor) family	ISS	604903	OMIM	PTHR12321:SF78	TAF  TBP-ASSOCIATED TRANSCRIPTION FACTOR  FAMILY
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CANLF|Ensembl=ENSCAFG00000013283|UniProtKB=E2RIZ9	Uncharacterized protein	IC	85270494	PubMed	PTHR18945:SF74	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA
P00029	Huntington disease	P00805	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00025	Hedgehog signaling pathway	P00682	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01438	PP2A	CANLF|Ensembl=ENSCAFG00000015787|UniProtKB=F6V7D9	Uncharacterized protein	ISS	8703017	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DANRE|ZFIN=ZDB-GENE-040426-1489|UniProtKB=Q6PHV0	Syntaxin 3A	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MONDO|Ensembl=ENSMODG00000020742|UniProtKB=F7A026	Uncharacterized protein	ISS	12629106	PubMed	PTHR24241:SF22	GONADOTROPIN-RELEASING HORMONE RECEPTOR
P00018	EGF receptor signaling pathway	P00546	GAP	MOUSE|MGI=MGI=1330842|UniProtKB=Q9Z268	RasGAP-activating-like protein 1	ISS	13529338	gi	PTHR10194:SF3	RASGAP-ACTIVATING-LIKE PROTEIN 1
P00029	Huntington disease	P00810	GAPDH	THEMA|EnsemblGenome=TM_0688|UniProtKB=P17721	Glyceraldehyde-3-phosphate dehydrogenase	IPI			PTHR43148:SF2	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE C-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	PANTR|Ensembl=ENSPTRG00000004079|UniProtKB=H2R1Z2	Uncharacterized protein	ISS	9388255	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00052	TGF-beta signaling pathway	P01276	Co-Smads	MACMU|Ensembl=ENSMMUG00000018334|UniProtKB=F7H894	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00018	EGF receptor signaling pathway	P00543	ERK1-2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DROME|FlyBase=FBgn0000045|UniProtKB=P02574	Actin, larval muscle	IDA	10974003	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	CHICK|Gene=CHRM3|UniProtKB=P49578	Muscarinic acetylcholine receptor M3	ISS	8100450	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P04398	p53 pathway feedback loops 2	P04665	AKT	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00810	GAPDH	GIAIC|EnsemblGenome=GL50803_17043|UniProtKB=E2RU88	Glyceraldehyde-3-phosphate dehydrogenase	IPI			PTHR10836:SF52	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	YEAST|SGD=S000005460|UniProtKB=Q12236	Serine/threonine-protein kinase PKH2	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	IC	188830	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	BOVIN|Gene=CHRNA3|UniProtKB=Q07263	Neuronal acetylcholine receptor subunit alpha-3	IC	12098588	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P00018	EGF receptor signaling pathway	P00563	Gab	MOUSE|MGI=MGI=2444981|UniProtKB=Q8K1N2	Pleckstrin homology-like domain family B member 2	ISS			PTHR12156:SF21	PLECKSTRIN HOMOLOGY-LIKE DOMAIN FAMILY B MEMBER 2
P00029	Huntington disease	G01533	Bax	RAT|RGD=2192|UniProtKB=Q63690	Apoptosis regulator BAX	ISS	11099028	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P06213	DPP signaling pathway	P06286	TKV	DROME|FlyBase=FBgn0003716|UniProtKB=Q9VMT1	Receptor protein serine/threonine kinase	TAS	9395284	PubMed	PTHR23255:SF68	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02738	De novo purine biosynthesis	P02907	dADP kinase	METAC|EnsemblGenome=MA_1524|UniProtKB=Q8TQL6	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	IDA	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00037	Ionotropic glutamate receptor pathway	P01020	NSF	MACMU|Ensembl=ENSMMUG00000005548|UniProtKB=F6YT14	Uncharacterized protein	ISS	601633	OMIM	PTHR23078:SF3	VESICLE-FUSING ATPASE
P02738	De novo purine biosynthesis	P02899	GMP synthase	PLAF7|EnsemblGenome=PF10_0123|UniProtKB=Q8IJR9	GMP synthase [glutamine-hydrolyzing]	ISS			PTHR11922:SF2	GMP SYNTHASE  GLUTAMINE-HYDROLYZING
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	IC	11035810	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00052	TGF-beta signaling pathway	P01275	P38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	PANTR|Ensembl=ENSPTRG00000003699|UniProtKB=H2Q3R5	Syntaxin 3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	MOUSE|MGI=MGI=106677|UniProtKB=Q8BRU6	Synaptic vesicular amine transporter	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	RCA	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02723	Adenine and hypoxanthine salvage pathway	P02811	Adenosine deaminase	ARATH|TAIR=AT4G04880|UniProtKB=Q8LPL7	Adenosine deaminase-like protein	ISS			PTHR11409:SF42	ADENOSINE DEAMINASE-LIKE PROTEIN
P00048	PI3 kinase pathway	P01196	PDK1	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	IDA	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00010	B cell activation	P00383	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IDA	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00007	Axon guidance mediated by semaphorins	P00340	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	8649368	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04398	p53 pathway feedback loops 2	P04657	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	NEUCR|EnsemblGenome=EFNCRG00000000525|UniProtKB=Q7SF97	Myosin type-2 heavy chain 2	IC			PTHR13140:SF555	MYOSIN HEAVY CHAIN, MUSCLE
P00021	FGF signaling pathway	P00640	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	DROME|FlyBase=FBgn0024150|UniProtKB=M9PID8	Adenylyl cyclase 78C, isoform E	IGI	20070553	PubMed	PTHR11920:SF453	ADENYLYL CYCLASE 78C, ISOFORM E
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00018	EGF receptor signaling pathway	P00551	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00624	14-3-3	CHICK|Gene_ORFName=RCJMB04_1e8|UniProtKB=Q5ZMT0	14-3-3 protein epsilon	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	9860142	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00020	FAS signaling pathway	P00615	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00054	Toll receptor signaling pathway	P01355	AP1	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00057	Wnt signaling pathway	P01452	NFAT	HUMAN|HGNC=7776|UniProtKB=Q13469	Nuclear factor of activated T-cells, cytoplasmic 2	IDA	12787506	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00053	T cell activation	P01336	Jnk	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	CANLF|Ensembl=ENSCAFG00000019633|UniProtKB=F1PDC7	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00010	B cell activation	P00379	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00006	Apoptosis signaling pathway	P00291	MEKK1	RAT|RGD=620966|UniProtKB=Q62925	Mitogen-activated protein kinase kinase kinase 1	ISS	12168099	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00047	PDGF signaling pathway	P01149	MNK1/2	RAT|RGD=1559603|UniProtKB=Q4G050	MAP kinase-interacting serine/threonine-protein kinase 1	ISS	11575158	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00021	FGF signaling pathway	P00628	JNK1-3	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04398	p53 pathway feedback loops 2	P04651	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00034	Integrin signalling pathway	P00916	Ras	CHICK|Ensembl=ENSGALG00000014033|UniProtKB=E1BTS2	Uncharacterized protein	ISS	99084794	PubMed	PTHR24070:SF186	GTPASE KRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MOUSE|MGI=MGI=1339967|UniProtKB=B1AR69	Protein Myh13	ISS	89264452	PubMed	PTHR13140:SF504	MYOSIN-13
P00020	FAS signaling pathway	P00615	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04559	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	10891487	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00009	Axon guidance mediated by netrin	P00363	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	DROME|FlyBase=FBgn0032151|UniProtKB=Q7KTF8	Nicotinic acetylcholine receptor alpha6, isoform E	ISS	85270494	PubMed	PTHR18945:SF763	NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA6, ISOFORM E
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00049	Parkinson disease	P01232	CASK	HUMAN|HGNC=1497|UniProtKB=O14936	Peripheral plasma membrane protein CASK	IPI	11679592	PubMed	PTHR23122:SF40	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MONDO|Ensembl=ENSMODG00000000771|UniProtKB=F6SSS3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00059	p53 pathway	G01579	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P05918	p38 MAPK pathway	P06040	MSK1	MOUSE|MGI=MGI=1920336|UniProtKB=Q8C050	Ribosomal protein S6 kinase alpha-5	RCA	9687510	PubMed	PTHR24351:SF115	RIBOSOMAL PROTEIN S6 KINASE ALPHA-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CAEEL|WormBase=WBGene00000067|UniProtKB=O45815	ACTin	IC	11889126	PubMed	PTHR11937:SF352	ACTIN
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95818|UniProtKB=Q61626	Glutamate receptor ionotropic, kainate 5	ISS	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00056	VEGF signaling pathway	P01413	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00779	TBP	PANTR|Ensembl=ENSPTRG00000018827|UniProtKB=H2RD22	Uncharacterized protein	ISS	11988536	PubMed	PTHR10126:SF20	TATA-BOX-BINDING PROTEIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Gene=DRD2|UniProtKB=Q9GJU1	D(2) dopamine receptor	IDA	2137198	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05918	p38 MAPK pathway	P06021	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	CANLF|Ensembl=ENSCAFG00000019633|UniProtKB=F1PDC7	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P04393	Ras Pathway	P04555	PDK	SCHPO|PomBase=SPBC1778.10c|UniProtKB=Q9Y7J6	Serine/threonine-protein kinase ppk21	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01305	Calmodulin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g239788|UniProtKB=A7RPI8	Predicted protein	ISS			PTHR23050:SF245	AT16150P-RELATED
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01472	Histone deacetylase	ORYSJ|EnsemblGenome=OS08G0344100|UniProtKB=Q6ZB59	Histone deacetylase	ISS	10485845	PubMed	PTHR10625:SF144	HISTONE DEACETYLASE 6-RELATED
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00778	NMDA receptor	XENTR|Xenbase=XB-GENE-494200|UniProtKB=F7CS79	Uncharacterized protein	ISS	11554554	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=98958|UniProtKB=P22725	Protein Wnt-5a	TAS	8717036	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P05916	Opioid prodynorphin pathway	P06002	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00005	Angiogenesis	P00206	Wnt	MOUSE|MGI=MGI=1261834|UniProtKB=O70283	Protein Wnt-2b	ISS	12549854	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	PANTR|Ensembl=ENSPTRG00000014922|UniProtKB=H2QML4	Uncharacterized protein	ISS	12169092	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	CAEEL|WormBase=WBGene00001613|UniProtKB=Q10914	Glutamate receptor 2	ISS	8804111	PubMed	PTHR18966:SF270	GLUTAMATE RECEPTOR 1-RELATED
P04392	P53 pathway feedback loops 1	P04539	p53	BOVIN|Ensembl=ENSBTAG00000001069|UniProtKB=P67939	Cellular tumor antigen p53	TAS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_127490|UniProtKB=C3XYC5	Putative uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00005	Angiogenesis	P00227	PLA2	MONDO|Ensembl=ENSMODG00000011791|UniProtKB=F7CBU9	Phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00060	Ubiquitin proteasome pathway	P01491	E2	DROME|FlyBase=FBgn0004436|UniProtKB=P25153	Ubiquitin-conjugating enzyme E2-17 kDa	ISS			PTHR43898:SF1	UBIQUITIN-CONJUGATING ENZYME E2-17 KDA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00006	Apoptosis signaling pathway	P00273	p53	PANTR|Ensembl=ENSPTRG00000008703|UniProtKB=H2QC53	Cellular tumor antigen p53	ISS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00002	Alpha adrenergic receptor signaling pathway	P00078	Alpha1A/1B/1C	RAT|RGD=2057|UniProtKB=P19328	Alpha-2B adrenergic receptor	IC	11781138	PubMed	PTHR24248:SF26	ALPHA-2B ADRENERGIC RECEPTOR
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000016097|UniProtKB=E1B9S9	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00057	Wnt signaling pathway	P01472	Histone deacetylase	TAKRU|Ensembl=ENSTRUG00000005364|UniProtKB=H2SKE2	Histone deacetylase	IDA	10485845	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P00060	Ubiquitin proteasome pathway	P01491	E2	ARATH|TAIR=AT2G36060|UniProtKB=Q9SJ44	Ubiquitin-conjugating enzyme E2 variant 1C	ISS			PTHR43915:SF6	UBIQUITIN-CONJUGATING ENZYME E2 VARIANT 1C
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MACMU|Ensembl=ENSMMUG00000010367|UniProtKB=F6R0F5	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF335	MYOSIN-11
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	ORYSJ|EnsemblGenome=OS12G0236400|UniProtKB=Q08479	Adenylate kinase 3	ISS			PTHR23359:SF22	GTP:AMP PHOSPHOTRANSFERASE, MITOCHONDRIAL
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000012036|UniProtKB=F7ALP1	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00005	Angiogenesis	P00222	VEGFR-2	MOUSE|MGI=MGI=96683|UniProtKB=P35918	Vascular endothelial growth factor receptor 2	ISS			PTHR24416:SF45	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00050	Plasminogen activating cascade	P01245	PAI-1	MACMU|Ensembl=ENSMMUG00000009926|UniProtKB=F6Y5D7	Uncharacterized protein	ISS	18092159	gi	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00029	Huntington disease	P00775	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00049	Parkinson disease	P01211	ERK	HUMAN|HGNC=24667|UniProtKB=Q8TD08	Mitogen-activated protein kinase 15	IDA	10514528	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	NEUCR|EnsemblGenome=EFNCRG00000002723|UniProtKB=Q1K5B4	Actin-related protein 2/3 complex subunit 5	ISS			PTHR12644:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	DANRE|ZFIN=ZDB-GENE-060531-50|UniProtKB=F1R6C7	Uncharacterized protein	ISS			PTHR13140:SF676	MYOSIN, HEAVY POLYPEPTIDE 2, FAST MUSCLE SPECIFIC
P00047	PDGF signaling pathway	P01173	STAT	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00034	Integrin signalling pathway	P00916	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P02763	Peptidoglycan biosynthesis	P03088	UDP-N-acetylmuramate dehydrogenase	LEPIN|EnsemblGenome=LA_3930|UniProtKB=Q8EZC5	UDP-N-acetylenolpyruvoylglucosamine reductase	ISS			PTHR21071:SF4	UDP-N-ACETYLENOLPYRUVOYLGLUCOSAMINE REDUCTASE
P00045	Notch signaling pathway	G01541	E(spl)-C genes	MOUSE|MGI=MGI=104853|UniProtKB=P35428	Transcription factor HES-1	ISS	14973298	PubMed	PTHR10985:SF19	TRANSCRIPTION FACTOR HES-1
P00034	Integrin signalling pathway	P00921	PINCH	XENTR|Xenbase=XB-GENE-967923|UniProtKB=F6UCA3	Uncharacterized protein	ISS			PTHR24210:SF0	AT21926P
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00059	p53 pathway	P04616	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00021	FGF signaling pathway	P00641	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00057	Wnt signaling pathway	P01455	Smad4	RAT|RGD=620158|UniProtKB=Q9R1V3	Mothers against decapentaplegic homolog 5	ISS	12736218	PubMed	PTHR13703:SF36	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CAEBR|Gene=CBG17587|UniProtKB=A8XRA5	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	IXOSC|EnsemblGenome=ISCW024111|UniProtKB=B7PBG2	Actin, putative (Fragment)	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	DROME|FlyBase=FBgn0039747|UniProtKB=Q9VAA2	Adenosine receptor, isoform A	IDA	12106606	PubMed	PTHR24246:SF27	ADENOSINE RECEPTOR A2A
P00006	Apoptosis signaling pathway	P00269	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10755300	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00021	FGF signaling pathway	P00639	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00048	PI3 kinase pathway	P01179	PKB	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=1768|UniProtKB=Q9ULB4	Cadherin-9	IDA	8120095	PubMed	PTHR24027:SF99	CADHERIN-9
P00019	Endothelin signaling pathway	P00568	PKC	DANRE|ZFIN=ZDB-GENE-040426-1178|UniProtKB=Q7SY24	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01143	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	G01540	BDNF	HUMAN|HGNC=1033|UniProtKB=P23560	Brain-derived neurotrophic factor	ISS	12117585	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02920	dCTP deaminase	SYNY3|Gene=BAA17764|UniProtKB=P73717	tRNA-specific adenosine deaminase	ISS			PTHR11079:SF149	TRNA-SPECIFIC ADENOSINE DEAMINASE
P00053	T cell activation	P01322	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	IGI	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	PANTR|Ensembl=ENSPTRG00000013825|UniProtKB=H2RAK4	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00051	TCA cycle	P01269	alphaketoglutarate Dehydrogenase	MACMU|Ensembl=ENSMMUG00000002651|UniProtKB=F7H508	Uncharacterized protein	ISS	12477932	PubMed	PTHR23152:SF7	2-OXOGLUTARATE DEHYDROGENASE, MITOCHONDRIAL
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	RAT|RGD=70958|UniProtKB=P19492	Glutamate receptor 3	IC	10331083	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00006	Apoptosis signaling pathway	P00308	Mcl1	MACMU|Ensembl=ENSMMUG00000008221|UniProtKB=F7HUE9	Induced myeloid leukemia cell differentiation protein Mcl-1 isoform 1	ISS	11877256	PubMed	PTHR11256:SF46	INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN MCL-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IDA	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00025	Hedgehog signaling pathway	P00689	Patched	CAEEL|WormBase=WBGene00004208|UniProtKB=Q09614	Protein patched homolog 1	ISS			PTHR10796:SF77	PROTEIN PATCHED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANAL|CGD=CAL0003231|UniProtKB=Q5ANK2	Protein kinase C	TAS	96408767	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00036	Interleukin signaling pathway	P00990	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008018|UniProtKB=F7EPG4	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00052	TGF-beta signaling pathway	P01284	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04579	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	10982827	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P05734	Synaptic vesicle trafficking	P05774	NSF	MONDO|Ensembl=ENSMODG00000011031|UniProtKB=F7F4B9	Uncharacterized protein	ISS	7969419	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	ISS	96320556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00050	Plasminogen activating cascade	P01245	PAI-1	HUMAN|HGNC=8583|UniProtKB=P05121	Plasminogen activator inhibitor 1	ISS	10692390	PubMed	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00018	EGF receptor signaling pathway	P00546	GAP	BOVIN|Ensembl=ENSBTAG00000015537|UniProtKB=E1B800	Uncharacterized protein	ISS	9877179	PubMed	PTHR10194:SF52	RAS GTPASE-ACTIVATING PROTEIN NGAP
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00053	T cell activation	P01333	cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00056	VEGF signaling pathway	P01415	MAPKAPK2/3	MOUSE|MGI=MGI=109298|UniProtKB=P49138	MAP kinase-activated protein kinase 2	ISS	9628873	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00049	Parkinson disease	P01230	Src kinase	HUMAN|HGNC=11283|UniProtKB=P12931	Proto-oncogene tyrosine-protein kinase Src	IDA	8054685	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	IC	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	15572354	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00019	Endothelin signaling pathway	P00583	cPLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BOVIN|Gene=ACTB|UniProtKB=P60712	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	DANRE|ZFIN=ZDB-GENE-980526-216|UniProtKB=Q04896	Homeobox protein engrailed-1a	IEP	12356903	PubMed	PTHR24341:SF4	HOMEOBOX PROTEIN ENGRAILED-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01192	p110	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02772	Pyruvate metabolism	P03137	Citrate Lyase	BOVIN|Ensembl=ENSBTAG00000004165|UniProtKB=A6QL68	CLYBL protein	ISS			PTHR11105:SF0	CITRATE LYASE SUBUNIT BETA-LIKE PROTEIN, MITOCHONDRIAL
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	MACMU|Ensembl=ENSMMUG00000008569|UniProtKB=F6UPU0	Uncharacterized protein	ISS	604905	OMIM	PTHR15319:SF1	TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT C
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MOUSE|MGI=MGI=1928896|UniProtKB=Q9R0Q6	Actin-related protein 2/3 complex subunit 1A	ISS	12963527	gi	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CHICK|Ensembl=ENSGALG00000003157|UniProtKB=E1C523	Uncharacterized protein	IC	89264452	PubMed	PTHR13140:SF358	MYOSIN-7B
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01471	alpha-catenin	RAT|RGD=1359485|UniProtKB=Q5U302	Catenin (Cadherin associated protein), alpha 1	ISS	1904011	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00059	p53 pathway	P04633	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	PANTR|Ensembl=ENSPTRG00000009085|UniProtKB=H2RDQ2	Uncharacterized protein	ISS	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04398	p53 pathway feedback loops 2	P04651	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CANLF|Ensembl=ENSCAFG00000003333|UniProtKB=F1PWT6	Uncharacterized protein	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00019	Endothelin signaling pathway	P00570	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P06215	MYO signaling pathway	P06313	SARA	DROME|FlyBase=FBgn0026369|UniProtKB=Q7K9H6	FI05490p	IEA	12040180	PubMed	PTHR22835:SF299	FI05490P
P02725	Allantoin degradation	P02823	Tartronate semi-aldehyde dehydrogenase	ECOLI|EcoGene=EG13265|UniProtKB=P77161	2-hydroxy-3-oxopropionate reductase	ISS			PTHR43060:SF7	3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	ARATH|TAIR=AT1G54100|UniProtKB=Q9SYG7	Aldehyde dehydrogenase family 7 member B4	IC			PTHR43521:SF1	ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE
P00025	Hedgehog signaling pathway	P00683	Slimb	CHICK|Ensembl=ENSGALG00000002229|UniProtKB=F1P5E8	Uncharacterized protein	ISS	10074433	PubMed	PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P00021	FGF signaling pathway	P00624	14-3-3	ORYSJ|EnsemblGenome=OS03G0710800|UniProtKB=Q06967	14-3-3-like protein GF14-F	ISS	10407019	PubMed	PTHR18860:SF40	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	MACMU|Ensembl=ENSMMUG00000015240|UniProtKB=F6VUY3	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P04397	p53 pathway by glucose deprivation	P04641	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00017	DNA replication	P00533	Pol delta	PANTR|Ensembl=ENSPTRG00000019138|UniProtKB=G2HH55	DNA polymerase subunit delta 2	ISS	96079106	PubMed	PTHR10416:SF0	DNA POLYMERASE DELTA SUBUNIT 2
P00050	Plasminogen activating cascade	P01253	Fibrin	PANTR|Ensembl=ENSPTRG00000016535|UniProtKB=H2QQB5	Uncharacterized protein	ISS	6575700	PubMed	PTHR19143:SF232	FIBRINOGEN ALPHA CHAIN
P00040	Metabotropic glutamate receptor group II pathway	G01540	BDNF	PANTR|Ensembl=ENSPTRG00000028696|UniProtKB=Q5IS78	Brain-derived neurotrophic factor	ISS	11724916	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	ARATH|TAIR=AT4G28880|UniProtKB=Q93Z18	Protein CASEIN KINASE I-LIKE 3	ISS	11437445	PubMed	PTHR11909:SF97	PROTEIN CASEIN KINASE I-LIKE 3-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00008	Axon guidance mediated by Slit/Robo	P00342	Slit	CANLF|Ensembl=ENSCAFG00000017027|UniProtKB=F1Q3G2	Uncharacterized protein	ISS			PTHR24373:SF15	SLIT HOMOLOG 3 PROTEIN
P04393	Ras Pathway	P04541	p90RSK	MONDO|Ensembl=ENSMODG00000006241|UniProtKB=F7FRY0	Ribosomal protein S6 kinase	ISS	1922062	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00056	VEGF signaling pathway	P01409	cPLA2	DANRE|ZFIN=ZDB-GENE-990415-45|UniProtKB=P50392	Cytosolic phospholipase A2	ISS	94299545	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	HUMAN|HGNC=2451|UniProtKB=P48729	Casein kinase I isoform alpha	ISS	10617630	PubMed	PTHR11909:SF84	CASEIN KINASE I ISOFORM ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	CANLF|Ensembl=ENSCAFG00000000132|UniProtKB=J9P309	Actin-related protein 2/3 complex subunit 3	ISS	12473693	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00021	FGF signaling pathway	P00634	MEKK1-5	RAT|RGD=1311192|UniProtKB=A0A0G2K3R1	Protein Map3k4	ISS	11730323	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	BOVIN|Ensembl=ENSBTAG00000019210|UniProtKB=F1MJV4	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000006307|UniProtKB=H2SSM1	Uncharacterized protein	IC			PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00641	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IGI	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	ARATH|TAIR=AT3G55940|UniProtKB=Q9LY51	Phosphoinositide phospholipase C 7	ISS			PTHR10336:SF92	PHOSPHOINOSITIDE PHOSPHOLIPASE C 2-RELATED
P00052	TGF-beta signaling pathway	P01284	JNK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	TAS	10514528	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00010	B cell activation	P00397	IKK	CANLF|Ensembl=ENSCAFG00000005526|UniProtKB=E2RKR0	Uncharacterized protein	ISS	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MACMU|Ensembl=ENSMMUG00000001661|UniProtKB=F7GR69	Uncharacterized protein	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06754	Ggamma	MOUSE|MGI=MGI=102705|UniProtKB=P63213	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	RCA	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00046	Oxidative stress response	P01135	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	TAS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00057	Wnt signaling pathway	P01444	Wnt	MACMU|Ensembl=ENSMMUG00000001325|UniProtKB=F7BGU5	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00049	Parkinson disease	P01242	Casein kinase I	HUMAN|HGNC=20289|UniProtKB=Q8N752	Casein kinase I isoform alpha-like	ISS	11437445	PubMed	PTHR11909:SF139	CASEIN KINASE I ISOFORM ALPHA-LIKE
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00047	PDGF signaling pathway	P01174	Rho	HUMAN|HGNC=675|UniProtKB=Q13017	Rho GTPase-activating protein 5	ISS			PTHR15377:SF4	RHO GTPASE-ACTIVATING PROTEIN 5
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	RCA	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9060|UniProtKB=P51178	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	10934033	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05918	p38 MAPK pathway	P06021	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CRYNJ|EnsemblGenome=CNA04650|UniProtKB=Q5KP06	Actin	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	ARATH|TAIR=AT1G28490|UniProtKB=Q946Y7	Syntaxin-61	ISS			PTHR19957:SF124	HL02043P
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CHICK|Gene=ACTG2|UniProtKB=P63270	Actin, gamma-enteric smooth muscle	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01087	CAT	DROME|FlyBase=FBgn0000303|UniProtKB=P07668	Choline O-acetyltransferase	IC	97225904	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05934	ELK1	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	10487205	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00024	Glycolysis	P00676	Glyceraldehyde 3-phosphate dehydrogenase	MOUSE|MGI=MGI=95640|UniProtKB=P16858	Glyceraldehyde-3-phosphate dehydrogenase	RCA			PTHR10836:SF51	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE
P00048	PI3 kinase pathway	P01192	p110	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MACMU|Ensembl=ENSMMUG00000001353|UniProtKB=F7D6T8	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P02741	Flavin biosynthesis	P02935	GTP cyclohydrolase	ARATH|TAIR=AT2G22450|UniProtKB=Q6NLQ7	Monofunctional riboflavin biosynthesis protein RIBA 2, chloroplastic	ISS			PTHR21327:SF31	MONOFUNCTIONAL RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBA 2, CHLOROPLASTIC
P00047	PDGF signaling pathway	P01167	Ets	MOUSE|MGI=MGI=95415|UniProtKB=P81270	Transcriptional regulator ERG	ISS	15298723	PubMed	PTHR11849:SF216	TRANSCRIPTIONAL REGULATOR ERG
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	HUMAN|HGNC=8528|UniProtKB=P01178	Oxytocin-neurophysin 1	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00012	Cadherin signaling pathway	P00467	alpha-catenin	MACMU|Ensembl=ENSMMUG00000017985|UniProtKB=F7DN31	Uncharacterized protein	ISS	1904011	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	LEPIN|EnsemblGenome=LA_1929|UniProtKB=Q8CXT1	CAP family transcription factor	IC	2372396	PubMed	PTHR45452:SF1	SUBFAMILY NOT NAMED
P00049	Parkinson disease	P01238	14-3-3	ORNAN|Ensembl=ENSOANG00000003572|UniProtKB=F7DGH9	Uncharacterized protein	ISS	14593000	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P05916	Opioid prodynorphin pathway	P06002	G-protein	RAT|RGD=621516|UniProtKB=G3V6P8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P05915	Opioid proenkephalin pathway	P05994	G-protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00540	MKK3,6	MOUSE|MGI=MGI=1346868|UniProtKB=O09110	Dual specificity mitogen-activated protein kinase kinase 3	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04398	p53 pathway feedback loops 2	P04651	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02920	dCTP deaminase	MYCTU|EnsemblGenome=LH57_20445|UniProtKB=O69719	tRNA-specific adenosine deaminase	ISS			PTHR11079:SF149	TRNA-SPECIFIC ADENOSINE DEAMINASE
P05917	Opioid proopiomelanocortin pathway	P06011	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00029	Huntington disease	P00807	Actin	DAPPU|EnsemblGenome=DAPPUDRAFT_228751|UniProtKB=E9HGF5	Cytoplasmatic actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00053	T cell activation	P01332	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00023	General transcription regulation	P00658	TBP-associated factors	MOUSE|MGI=MGI=1921719|UniProtKB=Q9D3R9	Transcription initiation factor TFIID subunit 7-like	ISS			PTHR12228:SF5	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 7-LIKE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DANRE|ZFIN=ZDB-GENE-040426-1354|UniProtKB=Q7T2C5	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00211	GSK3beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00057	Wnt signaling pathway	P01457	GBeta	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	ARATH|TAIR=AT5G43320|UniProtKB=Q9LSX4	Casein kinase 1-like protein 8	IDA	10617630	PubMed	PTHR11909:SF178	CASEIN KINASE 1-LIKE PROTEIN 8
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00056	VEGF signaling pathway	P01407	Erk	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	BOVIN|Ensembl=ENSBTAG00000011851|UniProtKB=A0JNB0	Tyrosine-protein kinase Fyn	ISS	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CAEBR|Gene=CBG17587|UniProtKB=A8XRA5	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00059	p53 pathway	P04633	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_115566|UniProtKB=C3XYC8	Putative uncharacterized protein	IDA	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00021	FGF signaling pathway	P00638	PLCgamma	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00059	p53 pathway	P04609	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	14505573	PubMed	PTHR10048:SF14	PI-3 KINASE
P00034	Integrin signalling pathway	P00927	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=2136746|UniProtKB=Q91UZ8	MCG141285	IDA	8120095	PubMed	PTHR24028:SF58	MCG141285
P00018	EGF receptor signaling pathway	P00559	MEK1-2	DROME|FlyBase=FBgn0010269|UniProtKB=Q24324	Dual specificity mitogen-activated protein kinase kinase dSOR1	ISS	176872	OMIM	PTHR24361:SF629	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P05918	p38 MAPK pathway	P06017	MNK2	RAT|RGD=1305728|UniProtKB=Q5U2N4	MAP kinase-interacting serine/threonine-protein kinase 2	ISS	11463832	PubMed	PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00030	Hypoxia response via HIF activation	P00818	HIF-1alpha	CANLF|Ensembl=ENSCAFG00000015718|UniProtKB=F1PZ54	Uncharacterized protein	ISS	14526383	PubMed	PTHR23043:SF7	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA
P00034	Integrin signalling pathway	P00916	Ras	MONDO|Gene=KRAS|UniProtKB=Q07983	GTPase KRas	ISS	9869449	PubMed	PTHR24070:SF186	GTPASE KRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00052	TGF-beta signaling pathway	P01286	TGFbeta	XENTR|Xenbase=XB-GENE-478930|UniProtKB=F6QUF3	Metalloendopeptidase	ISS	9759503	PubMed	PTHR43978:SF1	TOLLOID-LIKE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00923	Arf1	MONDO|Ensembl=ENSMODG00000024451|UniProtKB=F6Z8M9	Uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF234	ADP-RIBOSYLATION FACTOR 1
P00053	T cell activation	P01312	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00049	Parkinson disease	P01219	SAPK	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P02738	De novo purine biosynthesis	P02905	Amidophosphoribosyl transferase	PYRAE|EnsemblGenome=PAE0218|UniProtKB=Q8ZZK3	Amidophosphoribosyltransferase (PurF)	ISS			PTHR11907:SF17	SUBFAMILY NOT NAMED
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	ARATH|TAIR=AT3G27740|UniProtKB=Q9LVW7	Carbamoyl-phosphate synthase small chain, chloroplastic	ISS			PTHR11405:SF4	CARBAMOYL-PHOSPHATE SYNTHASE ARGININE-SPECIFIC SMALL CHAIN
P00005	Angiogenesis	P00227	PLA2	CHICK|Ensembl=ENSGALG00000005065|UniProtKB=P49147	Cytosolic phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P06664	Gonadotropin-releasing hormone receptor pathway	P06769	Gbeta	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	RCA	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	RAT|RGD=1566107|UniProtKB=D3ZBH0	Protein Creb5	RCA			PTHR19304:SF8	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 5
P00003	Alzheimer disease-amyloid secretase pathway	P00107	kinesin	MOUSE|MGI=MGI=1277971|UniProtKB=Q91W40	Kinesin light chain 3	IDA	11740561	PubMed	PTHR19959:SF125	KINESIN LIGHT CHAIN 3
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P01484	Chk2	MACMU|Ensembl=ENSMMUG00000020486|UniProtKB=F6ST42	Uncharacterized protein	ISS	12356735	PubMed	PTHR44167:SF1	SERINE/THREONINE-PROTEIN KINASE CHK2
P02747	Histidine biosynthesis	P02992	Imidazol glycerol phosphate synthase	THEMA|EnsemblGenome=TM_1038|UniProtKB=Q9X0C8	Imidazole glycerol phosphate synthase subunit HisH	ISS			PTHR42701:SF1	IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISH
P00029	Huntington disease	P00780	Microtubule	PHYPA|Gene=PHYPADRAFT_110341|UniProtKB=Q6TYR6	Beta-tubulin 2	ISS	12932731	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P05913	Enkephalin release	P05974	G-Protein (i)	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	IC	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	91056091	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00036	Interleukin signaling pathway	P00990	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00921	PINCH	BOVIN|Ensembl=ENSBTAG00000010971|UniProtKB=A4FV50	MGC142792 protein	ISS	10022929	PubMed	PTHR24210:SF11	LIM AND SENESCENT CELL ANTIGEN-LIKE-CONTAINING DOMAIN PROTEIN 1-RELATED
P00013	Cell cycle	P00481	APC	RAT|RGD=1308936|UniProtKB=B5DEP3	Anaphase-promoting complex subunit 10	ISS	7657035	gi	PTHR12936:SF0	ANAPHASE-PROMOTING COMPLEX SUBUNIT 10
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	IC	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00554	Shc	RAT|RGD=1307137|UniProtKB=O70142	SHC-transforming protein 2	ISS	600560	OMIM	PTHR10337:SF5	SHC-TRANSFORMING PROTEIN 2
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	PYRAE|EnsemblGenome=PAE0794|UniProtKB=Q8ZYG2	Cytidine deaminase	ISS			PTHR11644:SF2	CYTIDINE DEAMINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MOUSE|MGI=MGI=1915339|UniProtKB=P59999	Actin-related protein 2/3 complex subunit 4	ISS	9230079	PubMed	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEEL|WormBase=WBGene00018620|UniProtKB=O44588	Uncharacterized protein	IC	11880265	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P00057	Wnt signaling pathway	P01438	PP2A	ORNAN|Ensembl=ENSOANG00000008492|UniProtKB=F6XL57	Uncharacterized protein	ISS	12110603	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P02756	N-acetylglucosamine metabolism	P03041	Glucosamine-6-phosphate deaminase	PANTR|Ensembl=ENSPTRG00000017357|UniProtKB=H2QRP1	Glucosamine-6-phosphate isomerase	ISS			PTHR11280:SF8	GLUCOSAMINE-6-PHOSPHATE ISOMERASE 1
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02765	Phenylalanine biosynthesis	P03099	Prephenate dehydratase	SCHPO|PomBase=SPBC30D10.16|UniProtKB=O14361	Putative prephenate dehydratase	ISS			PTHR21022:SF0	PREPHENATE DEHYDRATASE-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	HUMAN|HGNC=10002|UniProtKB=P49758	Regulator of G-protein signaling 6	IDA	8756726	PubMed	PTHR10845:SF27	REGULATOR OF G-PROTEIN SIGNALING 6
P00029	Huntington disease	P00807	Actin	PANTR|Ensembl=ENSPTRG00000002086|UniProtKB=H2Q1A9	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	DROME|FlyBase=FBgn0260798|UniProtKB=P32865	G protein-coupled receptor kinase 1	IDA	8288567	PubMed	PTHR24355:SF18	PROTEIN-SERINE/THREONINE KINASE
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	MOUSE|MGI=MGI=1345146|UniProtKB=Q9WVL4	Rhodopsin kinase	ISS	8260489	PubMed	PTHR24355:SF11	RHODOPSIN KINASE
P00036	Interleukin signaling pathway	P00996	STAT	MACMU|Ensembl=ENSMMUG00000010707|UniProtKB=F7G8G5	Signal transducer and activator of transcription	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01307	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IPI	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00021	FGF signaling pathway	P00648	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00223	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	RCA			PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00554	Shc	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	ISS	8264585	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00049	Parkinson disease	P01227	20S proteasome	CHICK|Ensembl=ENSGALG00000019598|UniProtKB=E1C006	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF16	PROTEASOME SUBUNIT ALPHA TYPE-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00004	Alzheimer disease-presenilin pathway	P00114	actin	RAT|RGD=2027|UniProtKB=P63269	Actin, gamma-enteric smooth muscle	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00017	DNA replication	P00537	RPA	BOVIN|Ensembl=ENSBTAG00000006225|UniProtKB=Q2KI86	Replication protein A2, 32kDa	ISS	11731442	PubMed	PTHR13989:SF10	REPLICATION PROTEIN A 32 KDA SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	PANTR|Ensembl=ENSPTRG00000029367|UniProtKB=H2R6V7	Regulator of G-protein signaling 17	ISS	8756726	PubMed	PTHR10845:SF196	REGULATOR OF G-PROTEIN SIGNALING 17
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00005	Angiogenesis	P00252	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	8051109	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04398	p53 pathway feedback loops 2	G04709	MDM-2	BOVIN|Ensembl=ENSBTAG00000010422|UniProtKB=F1MYE6	Uncharacterized protein	ISS	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	HUMAN|HGNC=2452|UniProtKB=P48730	Casein kinase I isoform delta	IDA	11437445	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00034	Integrin signalling pathway	P00906	Rap1	BOVIN|Ensembl=ENSBTAG00000014710|UniProtKB=P62833	Ras-related protein Rap-1A	ISS	10476970	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00004	Alzheimer disease-presenilin pathway	P00172	BACE-1	MOUSE|MGI=MGI=1346542|UniProtKB=P56818	Beta-secretase 1	IDA	10956649	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P06664	Gonadotropin-releasing hormone receptor pathway	P06753	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	RCA	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P00053	T cell activation	P01294	NFAT	MACMU|Ensembl=ENSMMUG00000021843|UniProtKB=F6RNI3	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P04393	Ras Pathway	P04558	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00012	Cadherin signaling pathway	P00465	TCF/LEF	MACMU|Ensembl=ENSMMUG00000020134|UniProtKB=F6U055	Uncharacterized protein	ISS	9118222	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P02755	Methylmalonyl pathway	P03033	Propionyl-CoA carboxylase	HALSA|EnsemblGenome=VNG_0623G|UniProtKB=Q9HRN1	Propionyl-CoA carboxylase homolog	ISS			PTHR22855:SF13	METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P00036	Interleukin signaling pathway	P00996	STAT	CANLF|Ensembl=ENSCAFG00000015346|UniProtKB=E2RE22	Signal transducer and activator of transcription	ISS	95236292	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00037	Ionotropic glutamate receptor pathway	P01026	KA	PANTR|Ensembl=ENSPTRG00000013825|UniProtKB=H2RAK4	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00049	Parkinson disease	P01227	20S proteasome	MOUSE|MGI=MGI=104884|UniProtKB=O09061	Proteasome subunit beta type-1	TAS	12859888	PubMed	PTHR11599:SF59	PROTEASOME SUBUNIT BETA TYPE-1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9062|UniProtKB=Q9BRC7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	7822322	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00021	FGF signaling pathway	P00632	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MACMU|Ensembl=ENSMMUG00000010987|UniProtKB=F7GCX9	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00005	Angiogenesis	P00206	Wnt	DANRE|ZFIN=ZDB-GENE-980526-526|UniProtKB=P24257	Protein Wnt-1	ISS	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00006	Apoptosis signaling pathway	P00326	FAS ligand	PANTR|Ensembl=ENSPTRG00000001690|UniProtKB=H2Q0M2	Uncharacterized protein	ISS	12787569	PubMed	PTHR11471:SF33	TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 6
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	88234494	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00583	cPLA2	RAT|RGD=67366|UniProtKB=P50393	Cytosolic phospholipase A2	IGI	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	LEIMA|EnsemblGenome=LmjF.32.2950|UniProtKB=Q9U1E1	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04542	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01189	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P05912	Dopamine receptor mediated signaling pathway	P05970	TH	PANTR|Ensembl=ENSPTRG00000003173|UniProtKB=H2Q2W7	Uncharacterized protein	ISS	191290	OMIM	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00021	FGF signaling pathway	P00645	Rac	ARATH|TAIR=AT4G35020|UniProtKB=Q38912	Rac-like GTP-binding protein ARAC3	ISS			PTHR24072:SF249	RAC-LIKE GTP-BINDING PROTEIN ARAC3
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00048	PI3 kinase pathway	P01177	P110ACT	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00047	PDGF signaling pathway	P01142	p90RSK	RAT|RGD=1563860|UniProtKB=D3Z8E0	Ribosomal protein S6 kinase	ISS	10558991	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	PANTR|Ensembl=ENSPTRG00000034469|UniProtKB=H2Q2V0	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00053	T cell activation	P01332	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	IDA	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06812	L-type Ca2+	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	RCA	9199552	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00021	FGF signaling pathway	P00648	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00641	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00029	Huntington disease	P00794	Hippi	RAT|RGD=1305947|UniProtKB=D4A1V1	Intraflagellar transport 57 homolog (Chlamydomonas) (Predicted)	ISS	11889126	PubMed	PTHR16011:SF0	INTRAFLAGELLAR TRANSPORT PROTEIN 57 HOMOLOG
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05731	GABA-B receptor II signaling	P05754	Ggamma	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00021	FGF signaling pathway	P00632	Akt	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	ISS	14526383	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	IC	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04398	p53 pathway feedback loops 2	P04657	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00015	Circadian clock system	G01501	cry	DANRE|ZFIN=ZDB-GENE-010426-5|UniProtKB=F1QU08	Uncharacterized protein	ISS			PTHR11455:SF10	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00049	Parkinson disease	P01211	ERK	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	IDA	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	IDA	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00019	Endothelin signaling pathway	P00583	cPLA2	BOVIN|Ensembl=ENSBTAG00000013298|UniProtKB=A4IFJ5	Cytosolic phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00047	PDGF signaling pathway	P01153	GSK3	PANTR|Ensembl=ENSPTRG00000013342|UniProtKB=H2QK45	Uncharacterized protein	ISS			PTHR18905:SF12	NINEIN-LIKE PROTEIN
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	8925912	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00005	Angiogenesis	P00223	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	TAKRU|Ensembl=ENSTRUG00000015811|UniProtKB=H2UTX1	Serine/threonine-protein phosphatase	ISS	8392016	PubMed	PTHR11668:SF402	SERINE/THREONINE-PROTEIN PHOSPHATASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	IDA	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00049	Parkinson disease	P01227	20S proteasome	MOUSE|MGI=MGI=107637|UniProtKB=P70195	Proteasome subunit beta type-7	ISS	12859888	PubMed	PTHR11599:SF42	PROTEASOME SUBUNIT BETA TYPE-7
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CAEEL|WormBase=WBGene00004039|UniProtKB=Q21754	Phosphoinositide phospholipase C	ISS			PTHR10336:SF147	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00034	Integrin signalling pathway	P00923	Arf1	HUMAN|HGNC=692|UniProtKB=P40616	ADP-ribosylation factor-like protein 1	IPI	12932731	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P04398	p53 pathway feedback loops 2	P04668	p53	MACMU|Ensembl=ENSMMUG00000016569|UniProtKB=F6VXE7	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P05918	p38 MAPK pathway	P06021	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12912997	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IDA	2372396	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01192	p110	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	CHICK|Gene=ACTA2|UniProtKB=P08023	Actin, aortic smooth muscle	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	7925653	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	IC	15737619	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6879|UniProtKB=Q16659	Mitogen-activated protein kinase 6	IDA	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CANLF|Ensembl=ENSCAFG00000005662|UniProtKB=E2R907	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00047	PDGF signaling pathway	P01161	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00054	Toll receptor signaling pathway	P01341	Elk1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	ISS	11279280	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00021	FGF signaling pathway	P00630	RKIP	ORYSJ|EnsemblGenome=OS01G0111600|UniProtKB=Q9ASJ1	Protein MOTHER of FT and TFL1 homolog 2	ISS			PTHR11362:SF42	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	RAT|RGD=3187|UniProtKB=Q07008	Neurogenic locus notch homolog protein 1	IDA	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00057	Wnt signaling pathway	P01446	Calcineurin	HUMAN|HGNC=9318|UniProtKB=Q96LZ3	Calcineurin subunit B type 2	IDA	12015605	PubMed	PTHR23056:SF42	CALCINEURIN SUBUNIT B TYPE 2
P00034	Integrin signalling pathway	P00951	Jnk	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00640	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	ISS	10799299	PubMed	PTHR10048:SF14	PI-3 KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	HUMAN|HGNC=5960|UniProtKB=O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P06664	Gonadotropin-releasing hormone receptor pathway	P06834	MAP3Ks	MOUSE|MGI=MGI=1346875|UniProtKB=O08648	Mitogen-activated protein kinase kinase kinase 4	RCA	10207617	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	CANLF|Ensembl=ENSCAFG00000013143|UniProtKB=E2REE0	Uncharacterized protein	ISS			PTHR42884:SF12	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 7
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00029	Huntington disease	P00788	Calpain	HUMAN|HGNC=1486|UniProtKB=O14815	Calpain-9	IDA	11675509	PubMed	PTHR10183:SF385	CALPAIN-9
P00057	Wnt signaling pathway	P01444	Wnt	MACMU|Ensembl=ENSMMUG00000006621|UniProtKB=F7HKD3	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=621025|UniProtKB=Q62711	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	15611108	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00006	Apoptosis signaling pathway	P00302	ATF	RAT|RGD=621863|UniProtKB=Q9ES19	Cyclic AMP-dependent transcription factor ATF-4	ISS	11390664	PubMed	PTHR13044:SF2	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-4
P00029	Huntington disease	P00790	beta-Tubulin	PANTR|Ensembl=ENSPTRG00000017939|UniProtKB=Q7JJU6	Tubulin beta chain	ISS	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00051	TCA cycle	P01271	Fumarase	PANTR|Ensembl=ENSPTRG00000002163|UniProtKB=H2Q1E9	Uncharacterized protein	ISS	227665	gi	PTHR11444:SF1	FUMARATE HYDRATASE, MITOCHONDRIAL
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MONDO|Ensembl=ENSMODG00000023429|UniProtKB=F6XI83	Uncharacterized protein	ISS	11701344	PubMed	PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P02746	Heme biosynthesis	P02981	Glutamate-1-semialdehyde aminotransferase	PYRAE|EnsemblGenome=PAE0594|UniProtKB=Q8ZYW1	Glutamate-1-semialdehyde 2,1-aminomutase	ISS			PTHR43713:SF3	GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00053	T cell activation	P01312	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00048	PI3 kinase pathway	P01199	Galpha	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000001067|UniProtKB=E1BAB4	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02774	Salvage pyrimidine deoxyribonucleotides	P03146	Deoxyuridine kinase	THEMA|EnsemblGenome=TM_0401|UniProtKB=Q9WYN2	Thymidine kinase	ISS			PTHR11441:SF0	THYMIDINE KINASE, CYTOSOLIC
P02778	Sulfate assimilation	P03167	Sulfate adenylyltransferase	SCHPO|PomBase=SPBC27.08c|UniProtKB=P78937	Sulfate adenylyltransferase	ISS			PTHR42700:SF1	SULFATE ADENYLYLTRANSFERASE
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MOUSE|MGI=MGI=109349|UniProtKB=P16951	Cyclic AMP-dependent transcription factor ATF-2	TAS	10207617	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	RAT|RGD=3910|UniProtKB=P04652	Thyrotropin subunit beta	ISS	5101174	PubMed	PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P00015	Circadian clock system	G01499	per	RAT|RGD=61945|UniProtKB=Q9Z301	Period circadian protein homolog 2	ISS			PTHR11269:SF9	PERIOD CIRCADIAN PROTEIN HOMOLOG 2
P00011	Blood coagulation	P00458	GP IIIa	MACMU|Ensembl=ENSMMUG00000003289|UniProtKB=F7FG54	Integrin beta	ISS	386150	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00049	Parkinson disease	P01230	Src kinase	HUMAN|HGNC=6524|UniProtKB=P06239	Tyrosine-protein kinase Lck	IDA	1505025	PubMed	PTHR24418:SF39	TYROSINE-PROTEIN KINASE LCK
P00056	VEGF signaling pathway	P01423	p38MAPK	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	ISS	20451058	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04393	Ras Pathway	P04553	PAK	RAT|RGD=3251|UniProtKB=Q62829	Serine/threonine-protein kinase PAK 3	IDA	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P05730	Endogenous cannabinoid signaling	P05748	mGluR	MOUSE|MGI=MGI=1351338|UniProtKB=P97772	Metabotropic glutamate receptor 1	ISS	12488551	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	HUMAN|HGNC=20774|UniProtKB=P04350	Tubulin beta-4A chain	ISS	12932731	PubMed	PTHR11588:SF253	TUBULIN BETA-4A CHAIN
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	CANLF|Ensembl=ENSCAFG00000009967|UniProtKB=F1PGZ2	Muscarinic acetylcholine receptor	ISS	10069496	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	DROME|FlyBase=FBgn0028743|UniProtKB=Q8T017	Double hit, isoform B	IDA	8756726	PubMed	PTHR10845:SF192	AXIN-RELATED
P02761	Pantothenate biosynthesis	P03069	2-Dehydropantoate reductase	STRCO|Gene=CAB56722|UniProtKB=Q9RJH2	2-dehydropantoate 2-reductase	ISS			PTHR21708:SF26	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01149	MNK1/2	MOUSE|MGI=MGI=894279|UniProtKB=Q8CDB0	MAP kinase-interacting serine/threonine-protein kinase 2	ISS	11463832	PubMed	PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P00047	PDGF signaling pathway	P01163	c-Jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00018	EGF receptor signaling pathway	G01511	SPRY	PANTR|Ensembl=ENSPTRG00000016424|UniProtKB=H2QQ50	Sprouty homolog 1, antagonist of FGF signaling	ISS	98117253	PubMed	PTHR12365:SF10	PROTEIN SPROUTY HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	CAEBR|Gene=CBG20938|UniProtKB=A8XZ02	Protein CBR-RAS-1	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IGI	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00006	Apoptosis signaling pathway	P00313	IKK	MACMU|Ensembl=ENSMMUG00000008351|UniProtKB=F7HRV5	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00005	Angiogenesis	P00233	CSL	MONDO|Ensembl=ENSMODG00000000129|UniProtKB=F6YB95	Uncharacterized protein	ISS	12145413	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	DROME|FlyBase=FBgn0265434|UniProtKB=Q99323	Myosin heavy chain, non-muscle	ISS	89264452	PubMed	PTHR13140:SF574	MYOSIN HEAVY CHAIN, NON-MUSCLE
P00034	Integrin signalling pathway	P00912	Arp2/3	PANTR|Ensembl=ENSPTRG00000001767|UniProtKB=G2HG81	Actin-related protein 2/3 complex subunit 5	ISS	12932731	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	176910	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	MOUSE|MGI=MGI=1351339|UniProtKB=Q14BI2	Metabotropic glutamate receptor 2	ISS	9407094	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P05916	Opioid prodynorphin pathway	P06002	G-protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00012	Cadherin signaling pathway	P00475	Frizzled	HUMAN|HGNC=4038|UniProtKB=Q9UP38	Frizzled-1	IDA	12549854	PubMed	PTHR11309:SF81	FRIZZLED-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000003043|UniProtKB=P63212	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	HUMAN|HGNC=2558|UniProtKB=P49238	CX3C chemokine receptor 1	ISS	11960641	PubMed	PTHR10489:SF637	CX3C CHEMOKINE RECEPTOR 1
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=2683547|UniProtKB=Q4KWH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1	ISS	10934033	PubMed	PTHR10336:SF51	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-1
P00005	Angiogenesis	P00182	p38MAPK	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	TAS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01167	Ets	TAKRU|Ensembl=ENSTRUG00000010730|UniProtKB=H2TQW8	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF195	GA-BINDING PROTEIN ALPHA CHAIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PANTR|Ensembl=ENSPTRG00000018890|UniProtKB=Q5R1X3	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01411	Ras	DANRE|ZFIN=ZDB-GENE-040808-67|UniProtKB=Q6AZA4	K-ras	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	RAT|RGD=1306312|UniProtKB=D4A9D7	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	CANLF|Gene=ADCY6|UniProtKB=P30804	Adenylate cyclase type 6	IDA	2491850	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00056	VEGF signaling pathway	P01417	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00625	MKK3,6	MACMU|Ensembl=ENSMMUG00000001051|UniProtKB=F6QNB5	Dual specificity mitogen-activated protein kinase kinase 6	RCA			PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P02751	Lysine biosynthesis	P03009	Aspartokinase	ECOLI|EcoGene=EG10550|UniProtKB=P08660	Lysine-sensitive aspartokinase 3	ISS			PTHR21499:SF38	ASPARTOKINASE 1, CHLOROPLASTIC
P06664	Gonadotropin-releasing hormone receptor pathway	P06860	Rac1	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	RCA	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	PLAF7|EnsemblGenome=PF14_0352|UniProtKB=Q8IL94	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MACMU|Ensembl=ENSMMUG00000023587|UniProtKB=Q9XT45	C-X-C chemokine receptor type 6	ISS	11238560	PubMed	PTHR10489:SF705	C-X-C CHEMOKINE RECEPTOR TYPE 6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00009	Axon guidance mediated by netrin	P00364	cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01193	IRS	PANTR|Ensembl=ENSPTRG00000012989|UniProtKB=H2QJJ4	Insulin receptor substrate 1	ISS	1311924	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9062|UniProtKB=Q9BRC7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	15611108	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P06587	Nicotine pharmacodynamics pathway	P06605	KCNK3/9	HUMAN|HGNC=6283|UniProtKB=Q9NPC2	Potassium channel subfamily K member 9	RCA	15282272	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00018	EGF receptor signaling pathway	P00563	Gab	PANTR|Ensembl=ENSPTRG00000016471|UniProtKB=H2QQ79	GRB2-associated binding protein 1	ISS	4503851	gi	PTHR12156:SF18	GRB2-ASSOCIATED-BINDING PROTEIN 1
P00024	Glycolysis	P00679	Aldolase	XENTR|Xenbase=XB-GENE-1005023|UniProtKB=Q6NVQ9	Fructose-bisphosphate aldolase	ISS	99023741	PubMed	PTHR11627:SF3	FRUCTOSE-BISPHOSPHATE ALDOLASE C
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04541	p90RSK	BOVIN|Ensembl=ENSBTAG00000017639|UniProtKB=F1MZW8	Ribosomal protein S6 kinase	ISS	10480933	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	BOVIN|Ensembl=ENSBTAG00000013105|UniProtKB=E1BJ13	Uncharacterized protein	ISS			PTHR10024:SF176	SYNAPTOTAGMIN-3
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P02738	De novo purine biosynthesis	P02889	dGDP kinase	ARATH|TAIR=AT4G23900|UniProtKB=Q8LAH8	Nucleoside diphosphate kinase IV, chloroplastic/mitochondrial	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00049	Parkinson disease	P01208	Hsp70	ANOGA|EnsemblGenome=AGAP004944|UniProtKB=Q7Q7Y8	AGAP004944-PA	IDA	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00005	Angiogenesis	P00220	c-Jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8669|UniProtKB=Q9Y5H8	Protocadherin alpha-3	IDA	8120095	PubMed	PTHR24028:SF93	PROTOCADHERIN ALPHA-3
P00034	Integrin signalling pathway	P00924	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00924	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IPI	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00034	Integrin signalling pathway	P00912	Arp2/3	HUMAN|HGNC=704|UniProtKB=O15143	Actin-related protein 2/3 complex subunit 1B	IPI	9618202	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00060	Ubiquitin proteasome pathway	P01492	E1	ORNAN|Ensembl=ENSOANG00000000489|UniProtKB=F7EP98	Uncharacterized protein	ISS			PTHR10953:SF6	NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MONDO|Ensembl=ENSMODG00000011857|UniProtKB=F7GDB2	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF76	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5
P00054	Toll receptor signaling pathway	P01360	IKKbeta	RAT|RGD=621375|UniProtKB=Q9QY78	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00056	VEGF signaling pathway	P01408	Akt/PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00203	Erk	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	TRYB2|Gene=Tb927.7.5480|UniProtKB=Q582G3	Bifunctional dihydrofolate reductase-thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00012	Cadherin signaling pathway	P00474	Wnt	CANLF|Ensembl=ENSCAFG00000014987|UniProtKB=E2RH98	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P04396	Vitamin D metabolism and pathway	P04605	P450 reductase	YEAST|SGD=S000001084|UniProtKB=P16603	NADPH--cytochrome P450 reductase	TAS	2513880	PubMed	PTHR19384:SF17	NADPH--CYTOCHROME P450 REDUCTASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	TAS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	12885769	PubMed	PTHR10202:SF13	PRESENILIN-2
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	CRYNJ|EnsemblGenome=CNJ01230|UniProtKB=P0CS12	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P05916	Opioid prodynorphin pathway	P06002	G-protein	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=97438|UniProtKB=P32300	Delta-type opioid receptor	IDA	12093103	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00059	p53 pathway	P04609	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01429	Axin	DANRE|ZFIN=ZDB-GENE-000403-1|UniProtKB=P57094	Axin-1	IDA	9554852	PubMed	PTHR10845:SF11	AXIN-1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00011	Blood coagulation	P00440	ATIII	CANLF|Ensembl=ENSCAFG00000014470|UniProtKB=E2RES2	Uncharacterized protein	ISS	1082955	gi	PTHR11461:SF53	ANTITHROMBIN-III
P00029	Huntington disease	P00790	beta-Tubulin	IXOSC|EnsemblGenome=ISCW017136|UniProtKB=B7PA95	Beta tubulin	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P05730	Endogenous cannabinoid signaling	P05751	Galpha	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00048	PI3 kinase pathway	P01194	S6K	MACMU|Ensembl=ENSMMUG00000005483|UniProtKB=F7G271	Uncharacterized protein	ISS	15116068	PubMed	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01202	p85	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00049	Parkinson disease	P01211	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	97442349	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT2G18170|UniProtKB=Q39027	Mitogen-activated protein kinase 7	IDA	11707292	PubMed	PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	LEIMA|EnsemblGenome=LmjF.35.4010|UniProtKB=Q9GNR4	Protein kinase A catalytic subunit isoform 1	IC	10553940	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04558	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IDA	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00054	Toll receptor signaling pathway	P01345	IKKalpha	PANTR|Ensembl=ENSPTRG00000033948|UniProtKB=H2RBD4	Conserved helix-loop-helix ubiquitous kinase	ISS	12813046	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00221	JNK1	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00015	Circadian clock system	P00505	Cry	DANRE|ZFIN=ZDB-GENE-010426-3|UniProtKB=F1R1X1	Uncharacterized protein	ISS			PTHR11455:SF27	CRY1A PROTEIN
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00029	Huntington disease	P00778	NMDA receptor	CANLF|Ensembl=ENSCAFG00000002617|UniProtKB=E2QUL1	Uncharacterized protein	ISS	11554554	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00057	Wnt signaling pathway	P01465	Ggamma	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00021	FGF signaling pathway	P00644	p38	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	IDA	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00020	FAS signaling pathway	P00612	Fas	MACMU|Gene=FAS|UniProtKB=Q9BDP2	Tumor necrosis factor receptor superfamily member 6	TAS	10327065	PubMed	PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P00029	Huntington disease	P00786	ARF	MOUSE|MGI=MGI=1933155|UniProtKB=Q99PE9	ADP-ribosylation factor-like protein 4D	ISS	12932731	PubMed	PTHR11711:SF137	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 4D
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	ORNAN|Ensembl=ENSOANG00000005936|UniProtKB=F6PQC9	Uncharacterized protein	ISS	8576107	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	RCA			PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00562	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00629	PP2A	MONDO|Ensembl=ENSMODG00000019001|UniProtKB=F7CP86	Serine/threonine-protein phosphatase	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00034	Integrin signalling pathway	P00951	Jnk	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00005	Angiogenesis	P00182	p38MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	HUMAN|HGNC=16061|UniProtKB=Q9NQU5	Serine/threonine-protein kinase PAK 6	ISS			PTHR24361:SF182	SERINE/THREONINE-PROTEIN KINASE PAK 6
P04393	Ras Pathway	P04567	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	RAT|RGD=2735|UniProtKB=Q63273	Glutamate receptor ionotropic, kainate 5	ISS	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00012	Cadherin signaling pathway	P00475	Frizzled	CANLF|Gene=FZD6|UniProtKB=Q8WMU5	Frizzled-6	IDA	11212302	PubMed	PTHR11309:SF75	FRIZZLED-6
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00010	B cell activation	P00381	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00797	p53	MOUSE|MGI=MGI=1336991|UniProtKB=Q9JJP2	Tumor protein p73	TAS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000019277|UniProtKB=H2QUQ1	Uncharacterized protein	ISS	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P02747	Histidine biosynthesis	P02989	Phosphoribosyl AMP cyclohydrolase	LEPIN|EnsemblGenome=LB_079|UniProtKB=Q8EXX8	Phosphoribosyl-ATP pyrophosphatase	ISS			PTHR42945:SF1	HISTIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN HISIE, CHLOROPLASTIC
P00047	PDGF signaling pathway	P01161	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00020	FAS signaling pathway	P00615	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00010	B cell activation	P00384	p38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IDA	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00034	Integrin signalling pathway	P00907	ERK	BOVIN|Ensembl=ENSBTAG00000020079|UniProtKB=F1N3T0	Uncharacterized protein	ISS			PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IDA	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00034	Integrin signalling pathway	P00924	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00020	FAS signaling pathway	P00594	Caspase8	CHICK|Ensembl=ENSGALG00000008355|UniProtKB=F1NXP6	Uncharacterized protein	IGI	8681376	PubMed	PTHR10454:SF162	CASPASE-8
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CANLF|Ensembl=ENSCAFG00000014846|UniProtKB=E2RIZ5	Uncharacterized protein	ISS	10485843	PubMed	PTHR10005:SF3	SKI-LIKE PROTEIN
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MACMU|Ensembl=ENSMMUG00000006421|UniProtKB=F6U2K7	Uncharacterized protein	ISS	89298382	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P00029	Huntington disease	P00805	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01345	IKKalpha	MOUSE|MGI=MGI=99484|UniProtKB=Q60680	Inhibitor of nuclear factor kappa-B kinase subunit alpha	ISS	12235208	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01199	Galpha	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	MONDO|Ensembl=ENSMODG00000002696|UniProtKB=F7CY56	Uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF335	CALMODULIN, STRIATED MUSCLE
P00057	Wnt signaling pathway	P01444	Wnt	CANLF|Ensembl=ENSCAFG00000032632|UniProtKB=J9P2Q5	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=621025|UniProtKB=Q62711	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	7822322	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00029	Huntington disease	P00807	Actin	CHICK|Ensembl=ENSGALG00000009844|UniProtKB=P68034	Actin, alpha cardiac muscle 1	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01159	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00019	Endothelin signaling pathway	P00591	PLCbeta	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	IGI	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00018	EGF receptor signaling pathway	P00547	PP2A	BOVIN|Ensembl=ENSBTAG00000000469|UniProtKB=P67774	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IDA	10693759	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00037	Ionotropic glutamate receptor pathway	P01006	NR2C	RAT|RGD=2739|UniProtKB=Q00961	Glutamate receptor ionotropic, NMDA 2C	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00004	Alzheimer disease-presenilin pathway	P00159	Nectin 1alpha intracellular fragment	BOVIN|Ensembl=ENSBTAG00000015939|UniProtKB=F1MQJ3	Uncharacterized protein	ISS	12376527	PubMed	PTHR23277:SF69	NECTIN-1
P00036	Interleukin signaling pathway	P00990	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	TAS	3755548	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000023202|UniProtKB=F7EU36	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	CHICK|Ensembl=ENSGALG00000010812|UniProtKB=F1NLZ9	Uncharacterized protein	ISS	8930069	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00004	Alzheimer disease-presenilin pathway	P00117	E-cadherin C-terminal fragment	HUMAN|HGNC=1748|UniProtKB=P12830	Cadherin-1	IDA	8120095	PubMed	PTHR24027:SF319	CADHERIN-1
P05730	Endogenous cannabinoid signaling	P05746	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DICDI|dictyBase=DDB_G0275023|UniProtKB=Q553U6	Putative actin-22	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BRAFL|Gene=BRAFLDRAFT_220697|UniProtKB=C3ZSF0	Putative uncharacterized protein	ISS	9740024	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P02751	Lysine biosynthesis	P03012	N-succinyl-diaminopimelate desuccinylase	SULSO|EnsemblGenome=SSO1538|UniProtKB=Q97Y12	Succinyl-diaminopimelate desuccinylase (DapE)	ISS			PTHR43808:SF3	ACETYLORNITHINE DEACETYLASE
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MOUSE|MGI=MGI=1346874|UniProtKB=Q61084	Mitogen-activated protein kinase kinase kinase 3	ISS	8649450	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01179	PKB	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00269	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04395	Vasopressin synthesis	P04597	Signal Peptide	TAKRU|Ensembl=ENSTRUG00000015631|UniProtKB=H2USP0	Uncharacterized protein	ISS	6717565	PubMed	PTHR11681:SF14	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00647	SHP2	BOVIN|Ensembl=ENSBTAG00000020294|UniProtKB=A5D980	Tyrosine-protein phosphatase non-receptor type	ISS	14525967	PubMed	PTHR19134:SF65	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 6
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00057	Wnt signaling pathway	P01446	Calcineurin	ARATH|TAIR=AT5G47100|UniProtKB=Q9LTB8	Calcineurin B-like protein 9	IDA	12015605	PubMed	PTHR23056:SF41	CALCINEURIN B-LIKE PROTEIN 9
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	DROME|FlyBase=FBgn0001991|UniProtKB=Q24270	Voltage-dependent calcium channel type D subunit alpha-1	IC	11956331	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00048	PI3 kinase pathway	P01179	PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000018059|UniProtKB=C7G3M9	Glutamate receptor, metabotropic 4	ISS	9407094	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MACMU|Ensembl=ENSMMUG00000007052|UniProtKB=F7F147	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF25	MATRIX METALLOPROTEINASE-15
P00021	FGF signaling pathway	P00645	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01067	AChE	MACMU|Ensembl=ENSMMUG00000021257|UniProtKB=F7HPD6	Carboxylic ester hydrolase	ISS	87080761	PubMed	PTHR43918:SF3	ACETYLCHOLINESTERASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00859	NFkappaB	RAT|RGD=1589465|UniProtKB=D3ZQF8	Protein Bcl3	ISS			PTHR24118:SF51	B-CELL LYMPHOMA 3 PROTEIN
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IPI	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	PANTR|Gene=CXCR1|UniProtKB=P55920	C-X-C chemokine receptor type 1	ISS	9110929	PubMed	PTHR10489:SF916	C-X-C CHEMOKINE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01427	Naked	RAT|RGD=1311459|UniProtKB=D4A182	Naked cuticle 2 homolog (Drosophila) (Predicted)	ISS	11356022	PubMed	PTHR22611:SF1	PROTEIN NAKED CUTICLE HOMOLOG 2
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04393	Ras Pathway	P04569	Cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00029	Huntington disease	P00790	beta-Tubulin	PANTR|Ensembl=ENSPTRG00000017675|UniProtKB=H2QS81	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P00029	Huntington disease	P00777	CBP	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	RAT|RGD=619729|UniProtKB=O88204	Low-density lipoprotein receptor-related protein 3	IDA	11907044	PubMed	PTHR44062:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00572	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00018	EGF receptor signaling pathway	P00551	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00256	PLC-gamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00047	PDGF signaling pathway	P01143	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	21150461	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	8170357	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02744	Fructose galactose metabolism	P02965	UDP Glucose 4 epimerase	HUMAN|HGNC=4116|UniProtKB=Q14376	UDP-glucose 4-epimerase	RCA			PTHR43725:SF8	UDP-GLUCOSE 4-EPIMERASE
P00059	p53 pathway	P04609	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00005	Angiogenesis	P00222	VEGFR-2	CANLF|Ensembl=ENSCAFG00000002079|UniProtKB=Q2XPT7	Uncharacterized protein	ISS	11824379	PubMed	PTHR24416:SF45	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2
P02738	De novo purine biosynthesis	P02909	GDP reductase	HUMAN|HGNC=10451|UniProtKB=P23921	Ribonucleoside-diphosphate reductase large subunit	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000000289|UniProtKB=F7A9T0	Uncharacterized protein	ISS	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P02751	Lysine biosynthesis	P03008	Dihydrodipicolinate synthase	STRCO|EnsemblGenome=CAB46413|UniProtKB=Q9X9W0	4-hydroxy-tetrahydrodipicolinate synthase 1	ISS			PTHR12128:SF15	4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL
P04373	5HT1 type receptor mediated signaling pathway	P04409	5HT transporter	HUMAN|HGNC=11050|UniProtKB=P31645	Sodium-dependent serotonin transporter	IEA	14653308	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P00029	Huntington disease	P00775	Rac	PHYPA|Gene=PHYPADRAFT_170715|UniProtKB=A9TLC7	Rop-family small GTPase	TAS			PTHR24072:SF194	RAC-LIKE GTP-BINDING PROTEIN ARAC4-RELATED
P02772	Pyruvate metabolism	P03133	Pyruvate Dehydrogenase	CHLTR|EnsemblGenome=CT_245|UniProtKB=O84247	Pyruvate dehydrogenase E1 component subunit alpha	ISS	9784136	PubMed	PTHR11516:SF53	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00233	CSL	CAEEL|WormBase=WBGene00002245|UniProtKB=V6CLJ5	Lin-12 And Glp-1 phenotype	ISS			PTHR10665:SF0	SUPPRESSOR OF HAIRLESS PROTEIN
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	BOVIN|Ensembl=ENSBTAG00000003043|UniProtKB=P63212	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00046	Oxidative stress response	P01129	JNK1/2	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00049	Parkinson disease	P01211	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02728	Arginine biosynthesis	P02840	Argininosuccinate synthase	ECOLI|EcoGene=EG10068|UniProtKB=P0A6E4	Argininosuccinate synthase	ISS			PTHR11587:SF2	ARGININOSUCCINATE SYNTHASE
P00003	Alzheimer disease-amyloid secretase pathway	P00101	BACE-1	PANTR|Ensembl=ENSPTRG00000004324|UniProtKB=H2Q4U8	Beta-site APP-cleaving enzyme 1	ISS	10956649	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MACMU|Ensembl=ENSMMUG00000001458|UniProtKB=F7BKH1	Uncharacterized protein	ISS	12473693	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00019	Endothelin signaling pathway	P00591	PLCbeta	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IGI	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P02748	Isoleucine biosynthesis	P02994	Branched chain amino acid aminotransferase	MOUSE|MGI=MGI=104861|UniProtKB=P24288	Branched-chain-amino-acid aminotransferase, cytosolic	ISS			PTHR11825:SF51	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, CYTOSOLIC
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00019	Endothelin signaling pathway	P00591	PLCbeta	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00030	Hypoxia response via HIF activation	P00821	Prolyl Hydroxylase	MOUSE|MGI=MGI=1932286|UniProtKB=Q91YE3	Egl nine homolog 1	IDA	12912907	PubMed	PTHR12907:SF4	EGL NINE HOMOLOG 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P05916	Opioid prodynorphin pathway	P06002	G-protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00643	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01147	Nck	BOVIN|Ensembl=ENSBTAG00000018427|UniProtKB=Q1LZB2	NCK adaptor protein 1	ISS	11689432	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P00005	Angiogenesis	P00243	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00048	PI3 kinase pathway	P01188	Gbetagamma	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00053	T cell activation	P01312	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	DROME|FlyBase=FBgn0010399|UniProtKB=Q24418	Glutamate [NMDA] receptor subunit 1	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00005	Angiogenesis	P00188	Ets	MONDO|Ensembl=ENSMODG00000004730|UniProtKB=F6Y1Z2	Uncharacterized protein	ISS	15579511	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04570	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	RCA	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00029	Huntington disease	P00777	CBP	ARATH|TAIR=AT1G67220|UniProtKB=Q9FYH1	Histone acetyltransferase HAC2	IDA	8413673	PubMed	PTHR13808:SF6	HISTONE ACETYLTRANSFERASE HAC2
P05731	GABA-B receptor II signaling	P05752	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P06664	Gonadotropin-releasing hormone receptor pathway	G06897	Annexin A5	MOUSE|MGI=MGI=106008|UniProtKB=P48036	Annexin A5	RCA			PTHR10502:SF26	ANNEXIN A5
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00011	Blood coagulation	P00443	Fibrin polymer cross-linked	MOUSE|MGI=MGI=99501|UniProtKB=Q8K0E8	Fibrinogen beta chain	ISS	1706801	gi	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00054	Toll receptor signaling pathway	P01354	NFkappaB	MOUSE|MGI=MGI=97897|UniProtKB=P15307	Proto-oncogene c-Rel	ISS	11884420	PubMed	PTHR24169:SF4	PROTO-ONCOGENE C-REL
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00018	EGF receptor signaling pathway	P00552	Ras	DICPU|Gene=DICPUDRAFT_57324|UniProtKB=F0ZVH9	Putative uncharacterized protein rasS	ISS	94119591	PubMed	PTHR24070:SF380	RAS-LIKE PROTEIN RASS
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	MOUSE|MGI=MGI=1339656|UniProtKB=Q61036	Serine/threonine-protein kinase PAK 3	ISS	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	BOVIN|Gene=SLC1A1|UniProtKB=Q95135	Excitatory amino acid transporter 3	ISS	96032356	PubMed	PTHR11958:SF69	EXCITATORY AMINO ACID TRANSPORTER 3
P00057	Wnt signaling pathway	P01446	Calcineurin	BOVIN|Ensembl=ENSBTAG00000016005|UniProtKB=P48452	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	IDA	7532676	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IDA	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00006	Apoptosis signaling pathway	P00260	AKT	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	ISS	12655147	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02913	Thymidylate synthase	MACMU|Ensembl=ENSMMUG00000004046|UniProtKB=F6ZR77	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00060	Ubiquitin proteasome pathway	P01491	E2	ARATH|TAIR=AT5G42990|UniProtKB=Q9FMM0	Probable ubiquitin-conjugating enzyme E2 18	ISS			PTHR44452:SF1	UBIQUITIN-CONJUGATING ENZYME 15-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00010	B cell activation	P00386	Calcineurin	CHICK|Ensembl=ENSGALG00000005243|UniProtKB=E1C2T7	Serine/threonine-protein phosphatase	ISS	12015605	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00029	Huntington disease	P00807	Actin	DICDI|dictyBase=DDB_G0269234|UniProtKB=P07830	Major actin	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00029	Huntington disease	P00807	Actin	HUMAN|HGNC=132|UniProtKB=P60709	Actin, cytoplasmic 1	IDA	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00030	Hypoxia response via HIF activation	P00819	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	TAS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00005	Angiogenesis	P00219	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	CHICK|Ensembl=ENSGALG00000000366|UniProtKB=P18652	Ribosomal protein S6 kinase 2 alpha	ISS	6755374	gi	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000019277|UniProtKB=H2QUQ1	Uncharacterized protein	ISS	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=105372|UniProtKB=P49660	Somatostatin receptor type 4	IDA	12562507	PubMed	PTHR24229:SF52	SOMATOSTATIN RECEPTOR TYPE 4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000015717|UniProtKB=F6SFA9	Serotonin receptor type 1B	ISS	11701344	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P04373	5HT1 type receptor mediated signaling pathway	P04407	K+ channel	RAT|RGD=621451|UniProtKB=Q9ES08	Potassium channel subfamily K member 9	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00046	Oxidative stress response	P01126	ATF2	PANTR|Ensembl=ENSPTRG00000012660|UniProtKB=H2QJ07	Activating transcription factor 2	ISS	10487205	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00029	Huntington disease	P00786	ARF	TAKRU|Ensembl=ENSTRUG00000006254|UniProtKB=H2SS82	Uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	YEAST|SGD=S000000028|UniProtKB=P31109	Synaptobrevin homolog 1	IC			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	MOUSE|MGI=MGI=1917675|UniProtKB=Q8C4X2	Casein kinase I isoform gamma-3	ISS	10617630	PubMed	PTHR11909:SF151	CASEIN KINASE I ISOFORM GAMMA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	RAT|RGD=3562|UniProtKB=P49806	Regulator of G-protein signaling 10	ISS	8756726	PubMed	PTHR10845:SF182	REGULATOR OF G-PROTEIN SIGNALING 10
P00057	Wnt signaling pathway	P01440	Cadherin	CANLF|Ensembl=ENSCAFG00000018996|UniProtKB=E2R858	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF290	CADHERIN-10
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P02759	Pyridoxal-5-phosphate biosynthesis	P03058	Phosphohydroxythreonine aminotransferase	MACMU|Ensembl=ENSMMUG00000011868|UniProtKB=F7H2J8	Phosphoserine aminotransferase	ISS	2682527	PubMed	PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P00059	p53 pathway	P04609	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CHICK|Ensembl=ENSGALG00000002098|UniProtKB=F1P0L4	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00038	JAK/STAT signaling pathway	P01027	STAT	HUMAN|HGNC=11366|UniProtKB=P42229	Signal transducer and activator of transcription 5A	ISS	8732682	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P02775	Salvage pyrimidine ribonucleotides	P03149	Cytidine kinase	SCHPO|PomBase=SPCC162.11c|UniProtKB=O74427	Uridine kinase	ISS			PTHR10285:SF123	URIDINE KINASE
P00053	T cell activation	P01318	PKC-theta	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	SCHPO|PomBase=SPAC6G9.11|UniProtKB=Q92356	Synaptobrevin homolog 1	ISS			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	ISS	13430383	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P06959	CCKR signaling map	P07088	RYR1/2/3	HUMAN|HGNC=10485|UniProtKB=Q15413	Ryanodine receptor 3	RCA	10590314	PubMed	PTHR13715:SF16	RYANODINE RECEPTOR 3
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT1G18150|UniProtKB=Q9LM33	Mitogen-activated protein kinase 8	IDA			PTHR24055:SF246	MITOGEN-ACTIVATED PROTEIN KINASE 15-RELATED
P00020	FAS signaling pathway	P00601	c-Jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00057	Wnt signaling pathway	P01448	CBP	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	HUMAN|HGNC=7568|UniProtKB=P35580	Myosin-10	ISS	89264452	PubMed	PTHR13140:SF328	MYOSIN-10
P02788	Xanthine and guanine salvage pathway	P03249	Guanine deaminase	MACMU|Ensembl=ENSMMUG00000019196|UniProtKB=F7CWS1	Guanine deaminase isoform b	ISS	7533042	gi	PTHR11271:SF6	GUANINE DEAMINASE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00048	PI3 kinase pathway	P01198	FOXO	RAT|RGD=1309196|UniProtKB=D3ZBQ1	Forkhead box O3a (Predicted)	ISS	12884295	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	2837282	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00036	Interleukin signaling pathway	P00976	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00005	Angiogenesis	P00254	GTPase	RAT|RGD=735071|UniProtKB=Q5XIM3	Protein RSA-14-44	ISS			PTHR24072:SF165	PROTEIN 4930544G11RIK
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00059	p53 pathway	P04612	HDAC1	PANTR|Ensembl=ENSPTRG00000039785|UniProtKB=H2RGL2	Histone deacetylase	ISS	10485845	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	BRADU|EnsemblGenome=BAC49434|UniProtKB=P04772	Glutamine synthetase 2	ISS			PTHR20852:SF57	GLUTAMINE SYNTHETASE 2 CYTOPLASMIC
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IGI	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	HUMAN|HGNC=4588|UniProtKB=O15399	Glutamate receptor ionotropic, NMDA 2D	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2D.html	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MOUSE|MGI=MGI=1934582|UniProtKB=Q9EQ16	C-X-C chemokine receptor type 6	ISS	2209288	gi	PTHR10489:SF705	C-X-C CHEMOKINE RECEPTOR TYPE 6
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=1310389|UniProtKB=D3ZTF6	Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Predicted), isoform CRA_a	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00021	FGF signaling pathway	P00646	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	BOVIN|Ensembl=ENSBTAG00000003043|UniProtKB=P63212	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	BOVIN|Ensembl=ENSBTAG00000005464|UniProtKB=E1B9K3	Uncharacterized protein	ISS	93028552	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00223	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00309	Smac/Diablo	HUMAN|HGNC=21528|UniProtKB=Q9NR28	Diablo homolog, mitochondrial	ISS			PTHR32247:SF3	DIABLO HOMOLOG, MITOCHONDRIAL
P00049	Parkinson disease	P01234	GRK	MACMU|Ensembl=ENSMMUG00000023790|UniProtKB=F7HT93	Protein-serine/threonine kinase	ISS	10852916	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P06213	DPP signaling pathway	P06279	MED	DROME|FlyBase=FBgn0011655|UniProtKB=O62609	Mothers against decapentaplegic homolog	IEA	http://flybase.org/reports/FBgn0011655.html	Website	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	MACMU|Ensembl=ENSMMUG00000010678|UniProtKB=F7AXI7	Uncharacterized protein	ISS	192340	OMIM	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P02743	Formyltetrahydroformate biosynthesis	P02954	Thymidylate synthase	ARATH|TAIR=AT2G21550|UniProtKB=Q9SIK4	Bifunctional dihydrofolate reductase-thymidylate synthase	ISS			PTHR11548:SF7	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	DANRE|ZFIN=ZDB-GENE-060531-50|UniProtKB=F1R6C7	Uncharacterized protein	IC			PTHR13140:SF676	MYOSIN, HEAVY POLYPEPTIDE 2, FAST MUSCLE SPECIFIC
P00005	Angiogenesis	P00189	Fzd	HUMAN|HGNC=4038|UniProtKB=Q9UP38	Frizzled-1	IDA	8717036	PubMed	PTHR11309:SF81	FRIZZLED-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	YEAST|SGD=S000001295|UniProtKB=P07278	cAMP-dependent protein kinase regulatory subunit	IC	176892	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00633	Ras	DROME|FlyBase=FBgn0003205|UniProtKB=P08646	Ras-like protein 1	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00045	Notch signaling pathway	P01100	CoA	ORYSJ|EnsemblGenome=OS10G0415900|UniProtKB=Q338B9	Histone acetyltransferase GCN5	ISS	11112321	PubMed	PTHR22880:SF137	NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF
P00006	Apoptosis signaling pathway	P00321	HSP70	LEIMA|EnsemblGenome=LmjF.28.2770|UniProtKB=Q4Q7Y4	Putative heat-shock protein hsp70	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	PLAF7|EnsemblGenome=PF13_0287|UniProtKB=Q8IDF6	Adenylosuccinate synthetase	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	DANRE|ZFIN=ZDB-GENE-040625-35|UniProtKB=Q6IQL9	Novel actin protein	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00018	EGF receptor signaling pathway	P00559	MEK1-2	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CAEBR|Gene=CBG02401|UniProtKB=A8WUE7	Protein CBR-NMR-1	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	MOUSE|MGI=MGI=108100|UniProtKB=Q61062	Segment polarity protein dishevelled homolog DVL-3	TAS	10409711	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P00010	B cell activation	P00381	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00971	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8479536	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04413	K+ channel	HUMAN|HGNC=6278|UniProtKB=O14649	Potassium channel subfamily K member 3	ISS	15282272	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P02742	Tetrahydrofolate biosynthesis	P02945	Dihydropteroate synthase	LEPIN|EnsemblGenome=LA_0057|UniProtKB=Q8F9Y0	Dihydropteroate synthase	ISS			PTHR20941:SF1	FOLIC ACID SYNTHESIS PROTEIN FOL1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00036	Interleukin signaling pathway	P00996	STAT	PANTR|Ensembl=ENSPTRG00000009199|UniProtKB=H2QD19	Signal transducer and activator of transcription	ISS	96210005	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00041	Metabotropic glutamate receptor group I pathway	P01062	mGluR1	PANTR|Ensembl=ENSPTRG00000018684|UniProtKB=C7G3M7	Glutamate receptor, metabotropic 1	ISS	7476890	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00018	EGF receptor signaling pathway	P00564	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00223	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05913	Enkephalin release	P05977	G-Protein (s)	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	PANTR|Ensembl=ENSPTRG00000004701|UniProtKB=H2Q5G9	Low density lipoprotein receptor-related protein 6	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00018	EGF receptor signaling pathway	P00539	14-3-3	RAT|RGD=3979|UniProtKB=P68255	14-3-3 protein theta	ISS	10407019	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	LEIMA|EnsemblGenome=LmjF.18.1080|UniProtKB=Q27687	Protein kinase A catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00036	Interleukin signaling pathway	P00969	Signaling subunit	RAT|RGD=2903|UniProtKB=P40190	Interleukin-6 receptor subunit beta	TAS	10210178	PubMed	PTHR23036:SF83	INTERLEUKIN-6 RECEPTOR SUBUNIT BETA
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04556	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	PHYPA|Gene=PHYPADRAFT_210000|UniProtKB=A9S9L5	Predicted protein	ISS	9753452	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00046	Oxidative stress response	P01135	p38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00048	PI3 kinase pathway	P01192	p110	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	CHICK|Ensembl=ENSGALG00000003157|UniProtKB=E1C523	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF358	MYOSIN-7B
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CAEEL|WormBase=WBGene00001187|UniProtKB=Q8MQA1	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00021	FGF signaling pathway	P00638	PLCgamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00018	EGF receptor signaling pathway	P00557	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00558	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1354946|UniProtKB=Q61532	Mitogen-activated protein kinase 6	ISS	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00139	E-cadherin transmembrane fragment	RAT|RGD=69279|UniProtKB=Q9R0T4	Cadherin-1	IDA	11953314	PubMed	PTHR24027:SF319	CADHERIN-1
P00001	Adrenaline and noradrenaline biosynthesis	P00064	NET	CHICK|Ensembl=ENSGALG00000003560|UniProtKB=Q9DGN5	Transporter	ISS	97248649	PubMed	PTHR11616:SF37	SODIUM-DEPENDENT NORADRENALINE TRANSPORTER
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	MONDO|Ensembl=ENSMODG00000011192|UniProtKB=F6SRK5	Uncharacterized protein	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P06959	CCKR signaling map	P07146	ELK1	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	RCA	12239223	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CHICK|Ensembl=ENSGALG00000008898|UniProtKB=F1P2J9	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=96283|UniProtKB=P30966	5-hydroxytryptamine receptor 5A	IDA	12181435	PubMed	PTHR24247:SF108	5-HYDROXYTRYPTAMINE RECEPTOR 5A
P00029	Huntington disease	P00780	Microtubule	ORYSJ|EnsemblGenome=OS03G0105600|UniProtKB=Q8H7U1	Tubulin beta-2 chain	IDA	9454836	PubMed	PTHR11588:SF178	TUBULIN BETA-7 CHAIN
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04371	5-Hydroxytryptamine biosynthesis	P04400	Aromatic L-amino acid decarboxylase	RAT|RGD=2494|UniProtKB=P14173	Aromatic-L-amino-acid decarboxylase	IEA	90339966	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00047	PDGF signaling pathway	P01160	IP3 receptor	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00047	PDGF signaling pathway	P01167	Ets	XENTR|Xenbase=XB-GENE-6465484|UniProtKB=B3DM35	LOC100170599 protein	ISS	2205841	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04494	TSC2	MACMU|Ensembl=ENSMMUG00000002808|UniProtKB=F7H034	Uncharacterized protein	ISS	15249583	PubMed	PTHR10063:SF0	TUBERIN
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00007	Axon guidance mediated by semaphorins	P00339	CRMP	PANTR|Ensembl=ENSPTRG00000015878|UniProtKB=H2RDF9	Uncharacterized protein	ISS	96424532	PubMed	PTHR11647:SF54	DIHYDROPYRIMIDINASE-RELATED PROTEIN 1
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	CANLF|Ensembl=ENSCAFG00000003333|UniProtKB=F1PWT6	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00021	FGF signaling pathway	P00627	ERK1-2	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	11790551	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	IC	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00807	Actin	CANLF|Ensembl=ENSCAFG00000008756|UniProtKB=F2Z4N8	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00047	PDGF signaling pathway	P01154	Ras	DICDI|dictyBase=DDB_G0283537|UniProtKB=P32254	Ras-like protein rasS	ISS	94119591	PubMed	PTHR24070:SF380	RAS-LIKE PROTEIN RASS
P00047	PDGF signaling pathway	P01173	STAT	MONDO|Ensembl=ENSMODG00000014836|UniProtKB=F7D2D3	Signal transducer and activator of transcription	ISS	95236292	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00059	p53 pathway	P01486	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01192	p110	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00794	Hippi	MOUSE|MGI=MGI=1921166|UniProtKB=Q8BXG3	Intraflagellar transport protein 57 homolog	IDA	11788820	PubMed	PTHR16011:SF0	INTRAFLAGELLAR TRANSPORT PROTEIN 57 HOMOLOG
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DANRE|ZFIN=ZDB-GENE-040426-1354|UniProtKB=Q7T2C5	Protein kinase C	ISS	11880265	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00050	Plasminogen activating cascade	P01253	Fibrin	RAT|RGD=2603|UniProtKB=P06399	Fibrinogen alpha chain	IEP	1706800	gi	PTHR19143:SF232	FIBRINOGEN ALPHA CHAIN
P00045	Notch signaling pathway	P01111	LNXp80	HUMAN|HGNC=6657|UniProtKB=Q8TBB1	E3 ubiquitin-protein ligase LNX	IC			PTHR19964:SF14	E3 UBIQUITIN-PROTEIN LIGASE LNX
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00045	Notch signaling pathway	P01110	Presenilin	CAEEL|WormBase=WBGene00001985|UniProtKB=O02100	Presenilin hop-1	IGI	8755489	PubMed	PTHR10202:SF14	PRESENILIN HOP-1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00020	FAS signaling pathway	P00615	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00029	Huntington disease	P00807	Actin	DANRE|ZFIN=ZDB-GENE-030131-1229|UniProtKB=Q6DHS1	Actin, alpha 2, smooth muscle, aorta	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00021	FGF signaling pathway	P00623	FGF	BOVIN|Ensembl=ENSBTAG00000004013|UniProtKB=E1BEB9	Fibroblast growth factor	ISS	14527678	PubMed	PTHR11486:SF20	FIBROBLAST GROWTH FACTOR 7
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04398	p53 pathway feedback loops 2	G04714	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000004170|UniProtKB=H2R515	Uncharacterized protein	ISS			PTHR43962:SF6	MELATONIN RECEPTOR TYPE 1B
P00005	Angiogenesis	P00219	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00012	Cadherin signaling pathway	P00464	Fyn	HUMAN|HGNC=4037|UniProtKB=P06241	Tyrosine-protein kinase Fyn	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00018	EGF receptor signaling pathway	P00552	Ras	BOVIN|Ensembl=ENSBTAG00000009778|UniProtKB=E1BMX0	Uncharacterized protein	ISS	9869449	PubMed	PTHR24070:SF186	GTPASE KRAS
P00009	Axon guidance mediated by netrin	P00366	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	4757952	gi	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00045	Notch signaling pathway	P01115	Neurotic	MACMU|Ensembl=ENSMMUG00000008979|UniProtKB=F7HIR8	Uncharacterized protein	RCA			PTHR21420:SF3	GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	CANLF|Ensembl=ENSCAFG00000013778|UniProtKB=F6UQ33	Phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1203729|UniProtKB=Q61194	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MACMU|Ensembl=ENSMMUG00000009341|UniProtKB=F6UA54	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	DANRE|ZFIN=ZDB-GENE-030821-1|UniProtKB=Q8JH70	Fructose-bisphosphate aldolase C-B	ISS	1703244	gi	PTHR11627:SF3	FRUCTOSE-BISPHOSPHATE ALDOLASE C
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00047	PDGF signaling pathway	P01159	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00021	FGF signaling pathway	P00634	MEKK1-5	HUMAN|HGNC=6857|UniProtKB=Q99683	Mitogen-activated protein kinase kinase kinase 5	IGI	8974401	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	TAS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02772	Pyruvate metabolism	P03132	Pyruvate Kinase	ARATH|TAIR=AT5G08570|UniProtKB=Q9FNN1	Pyruvate kinase	TAS	15242863	gi	PTHR11817:SF3	AT14039P-RELATED
P00007	Axon guidance mediated by semaphorins	P00336	Cdk5	PANTR|Ensembl=ENSPTRG00000019872|UniProtKB=H2QVM3	Cyclin-dependent kinase 5	ISS			PTHR24056:SF46	CYCLIN-DEPENDENT-LIKE KINASE 5
P00049	Parkinson disease	P01211	ERK	HUMAN|HGNC=24667|UniProtKB=Q8TD08	Mitogen-activated protein kinase 15	IDA	12787066	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00010	B cell activation	P00402	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	BOVIN|Ensembl=ENSBTAG00000020136|UniProtKB=A5D7B9	CASK protein	ISS	11679592	PubMed	PTHR23122:SF40	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P00005	Angiogenesis	P00226	Delta/Serrate	ORNAN|Ensembl=ENSOANG00000008425|UniProtKB=F6VUQ4	Delta-like protein	ISS	1286675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04397	p53 pathway by glucose deprivation	P04641	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P02738	De novo purine biosynthesis	P02900	AICAR transformylase	FUSNN|EnsemblGenome=FN0982|UniProtKB=Q8REV6	Bifunctional purine biosynthesis protein PurH	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00845	Cyclooxygenase	CANLF|Ensembl=ENSCAFG00000013762|UniProtKB=Q8SPQ9	Cyclooxygenase 2	ISS	11861541	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P05913	Enkephalin release	P05972	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	RAT|RGD=620023|UniProtKB=P10980	Muscarinic acetylcholine receptor M2	TAS	12181435	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00005	Angiogenesis	P00206	Wnt	HUMAN|HGNC=12781|UniProtKB=Q93097	Protein Wnt-2b	IEA	11266476	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00059	p53 pathway	G04694	p110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00054	Toll receptor signaling pathway	P01375	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00036	Interleukin signaling pathway	P00981	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANAL|CGD=CAL0068551|UniProtKB=Q5AAR9	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00056	VEGF signaling pathway	P01411	Ras	DICPU|Gene=DICPUDRAFT_47179|UniProtKB=F0ZI47	Putative uncharacterized protein rasB	ISS	93205383	PubMed	PTHR24070:SF206	RAS-LIKE PROTEIN RASB
P00029	Huntington disease	G01532	PolyQ HTT	HUMAN|HGNC=4851|UniProtKB=P42858	Huntingtin	TAS	9462744	PubMed	PTHR10170:SF10	HUNTINGTIN
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04552	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	IDA	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00004	Alzheimer disease-presenilin pathway	P00163	Erb-B4 C-terminal fragment	MONDO|Ensembl=ENSMODG00000015755|UniProtKB=F6ZSZ9	Uncharacterized protein (Fragment)	ISS	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CIOIN|Ensembl=ENSCING00000001377|UniProtKB=F6SDC9	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	PANTR|Ensembl=ENSPTRG00000002007|UniProtKB=H2Q165	TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa	ISS	600075	OMIM	PTHR32122:SF1	TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT A
P00034	Integrin signalling pathway	P00944	Actin	MONDO|Ensembl=ENSMODG00000023202|UniProtKB=F7EU36	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00034	Integrin signalling pathway	P00916	Ras	NEUCR|EnsemblGenome=EFNCRG00000008769|UniProtKB=P22126	Protein ras-1	IPI	7997267	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00006	Apoptosis signaling pathway	P00291	MEKK1	MACMU|Ensembl=ENSMMUG00000012387|UniProtKB=F7EB20	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00057	Wnt signaling pathway	P01465	Ggamma	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00052	TGF-beta signaling pathway	P01275	P38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MACMU|Ensembl=ENSMMUG00000010367|UniProtKB=F6R0F5	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF335	MYOSIN-11
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	XENTR|Xenbase=XB-GENE-1012455|UniProtKB=F6TKH3	Uncharacterized protein (Fragment)	ISS			PTHR11824:SF7	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4
P00019	Endothelin signaling pathway	P00589	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00011	Blood coagulation	P00421	alpha1-antitrypsin	HUMAN|HGNC=8941|UniProtKB=P01009	Alpha-1-antitrypsin	ISS	112888	gi	PTHR11461:SF165	ALPHA-1-ANTITRYPSIN-RELATED
P00019	Endothelin signaling pathway	P00566	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01336	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00558	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00018	EGF receptor signaling pathway	P00549	EGF	RAT|RGD=1559678|UniProtKB=F1M182	Protein Nrg3	RCA			PTHR11100:SF18	PRO-NEUREGULIN-3, MEMBRANE-BOUND ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95815|UniProtKB=P39087	Glutamate receptor ionotropic, kainate 2	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00053	T cell activation	P01331	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00036	Interleukin signaling pathway	P00965	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	IC	11790551	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04375	5HT3 type receptor mediated signaling pathway	P04421	5HT transporter	MOUSE|MGI=MGI=96285|UniProtKB=Q60857	Sodium-dependent serotonin transporter	ISS	14653308	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TRIAD|EnsemblGenome=TriadG35956|UniProtKB=Q7YTV5	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00005	Angiogenesis	P00219	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	HUMAN|HGNC=4586|UniProtKB=Q13224	Glutamate receptor ionotropic, NMDA 2B	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DANRE|ZFIN=ZDB-GENE-040426-1354|UniProtKB=Q7T2C5	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	227170	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	LEIMA|Gene=LmjF13.1190|UniProtKB=Q4QG35	Adenylosuccinate synthetase	ISS			PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01444	Wnt	MACMU|Ensembl=ENSMMUG00000018445|UniProtKB=F7HEW6	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P02726	Aminobutyrate degradation	P02824	Succinate semi-aldehyde dehydrogenase	DEIRA|EnsemblGenome=DR_A0003|UniProtKB=Q9RZE6	Succinate-semialdehyde dehydrogenase	ISS	12891648	PubMed	PTHR43353:SF5	SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PHYPA|Gene=PHYPADRAFT_172686|UniProtKB=A9TYG6	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05915	Opioid proenkephalin pathway	P05994	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00047	PDGF signaling pathway	P01171	PLCgamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	HUMAN|HGNC=129|UniProtKB=P68133	Actin, alpha skeletal muscle	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00012	Cadherin signaling pathway	P00470	F-actin	DROME|FlyBase=FBgn0000046|UniProtKB=P10981	Actin-87E	IC	14684598	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	MACMU|Ensembl=ENSMMUG00000022596|UniProtKB=F6Z7T2	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF5	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04580	TRH Receptor	XENTR|Xenbase=XB-GENE-6492473|UniProtKB=F7C4A2	Uncharacterized protein	ISS			PTHR24243:SF119	SUBFAMILY NOT NAMED
P00059	p53 pathway	G01579	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	176910	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05916	Opioid prodynorphin pathway	P06002	G-protein	DAPPU|EnsemblGenome=DAPPUDRAFT_59367|UniProtKB=E9H7Z0	Guanine nucleotide-binding protein G(O) subunit alpha 1	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01238	14-3-3	DAPPU|EnsemblGenome=DAPPUDRAFT_326737|UniProtKB=E9H8M4	Putative uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00005	Angiogenesis	P00187	beta catenin	PANTR|Ensembl=ENSPTRG00000023062|UniProtKB=H2R2U1	Catenin (Cadherin-associated protein), beta 1, 88kDa	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00057	Wnt signaling pathway	P01451	Galpha	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	IPI	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	PANTR|Ensembl=ENSPTRG00000011042|UniProtKB=H2QGF5	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00047	PDGF signaling pathway	P01168	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00059	p53 pathway	P04623	CBP	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	STRPU|EnsemblGenome=SPU_005033|UniProtKB=W4XNQ0	Uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF263	SUBFAMILY NOT NAMED
P02738	De novo purine biosynthesis	P02889	dGDP kinase	MOUSE|MGI=MGI=1930182|UniProtKB=Q9WV85	Nucleoside diphosphate kinase 3	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P02749	Leucine biosynthesis	P03001	3-Isopropylmalate dehydrogenase	ARATH|TAIR=AT5G14200|UniProtKB=Q9FMT1	3-isopropylmalate dehydrogenase 3, chloroplastic	ISS			PTHR42979:SF3	3-ISOPROPYLMALATE DEHYDROGENASE 1, CHLOROPLASTIC-RELATED
P00052	TGF-beta signaling pathway	P01286	TGFbeta	BOVIN|Ensembl=ENSBTAG00000005176|UniProtKB=F6S0Q2	Uncharacterized protein	ISS	10779363	PubMed	PTHR12173:SF1	GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR
P00036	Interleukin signaling pathway	P00966	mTOR	CANLF|Ensembl=ENSCAFG00000016648|UniProtKB=E2R2L2	Uncharacterized protein	ISS	8662507	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	DANRE|ZFIN=ZDB-GENE-030425-5|UniProtKB=A8E5L7	Cited3 protein	TAS	9865691	PubMed	PTHR17045:SF5	CBP/P300-INTERACTING TRANSACTIVATOR 4
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MONDO|Ensembl=ENSMODG00000012546|UniProtKB=F6PM16	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	PANTR|Ensembl=ENSPTRG00000017238|UniProtKB=H2QRH7	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00547	PP2A	MONDO|Ensembl=ENSMODG00000019001|UniProtKB=F7CP86	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	MACMU|Ensembl=ENSMMUG00000022009|UniProtKB=F6RBZ7	Cell division control protein 42 homolog isoform 2	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04397	p53 pathway by glucose deprivation	P04640	p53	MACMU|Ensembl=ENSMMUG00000016569|UniProtKB=F6VXE7	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P02746	Heme biosynthesis	P02970	Coproporphyrinogen oxidase (oxygen independent)	AQUAE|EnsemblGenome=aq_1424|UniProtKB=O67418	Oxygen-independent coproporphyrinogen III oxidase	ISS			PTHR13932:SF5	OXYGEN-INDEPENDENT COPROPORPHYRINOGEN-III OXIDASE-LIKE PROTEIN YGGW
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IDA	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	89186920	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MONDO|Ensembl=ENSMODG00000006594|UniProtKB=F7AKA6	Uncharacterized protein	ISS	602425	OMIM	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00006	Apoptosis signaling pathway	P00270	Bcl-2	RAT|RGD=2199|UniProtKB=P49950	Apoptosis regulator Bcl-2	IDA	2250705	PubMed	PTHR11256:SF11	APOPTOSIS REGULATOR BCL-2
P00008	Axon guidance mediated by Slit/Robo	P00343	Ptp10D	DROME|FlyBase=FBgn0004370|UniProtKB=P35992	Tyrosine-protein phosphatase 10D	ISS	10648238	PubMed	PTHR19134:SF360	PROTEIN TYROSINE PHOSPHATASE 4E, ISOFORM A-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	PANTR|Ensembl=ENSPTRG00000017267|UniProtKB=H2QRJ4	Uncharacterized protein	ISS	11055438	PubMed	PTHR10117:SF9	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 7
P04393	Ras Pathway	P04553	PAK	MONDO|Ensembl=ENSMODG00000018459|UniProtKB=F7CU42	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02770	Pyridoxal phosphate salvage pathway	P03121	Pyridoxal kinase	HUMAN|HGNC=8819|UniProtKB=O00764	Pyridoxal kinase	ISS	9099727	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P00049	Parkinson disease	P01211	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	IDA	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02738	De novo purine biosynthesis	P02901	Adenosuccinate lyase	CHICK|Gene=ADSL|UniProtKB=P21265	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=16265|UniProtKB=Q9H1J7	Protein Wnt-5b	IDA	11266476	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00053	T cell activation	P01307	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00005	Angiogenesis	P00182	p38MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00005	Angiogenesis	P00226	Delta/Serrate	CHICK|Ensembl=ENSGALG00000009020|UniProtKB=E1BTW5	Delta-like protein	ISS	8631496	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	TAS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000008189|UniProtKB=H2QB91	Cadherin 11, type 2, OB-cadherin (Osteoblast)	ISS	8120095	PubMed	PTHR24027:SF85	CADHERIN-11
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05916	Opioid prodynorphin pathway	P06002	G-protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000020887|UniProtKB=F1MP22	Uncharacterized protein	ISS	8386525	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00034	Integrin signalling pathway	P00911	B-Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P04391	Oxytocin receptor mediated signaling pathway	P04531	Oxytocin Receptor	BOVIN|Ensembl=ENSBTAG00000019772|UniProtKB=P56449	Oxytocin receptor	ISS	11006161	PubMed	PTHR24241:SF19	OXYTOCIN RECEPTOR
P04398	p53 pathway feedback loops 2	P04649	Myc	PANTR|Gene=MYC|UniProtKB=P23583	Myc proto-oncogene protein	TAS	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	15572354	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IDA	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00048	PI3 kinase pathway	P01181	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05915	Opioid proenkephalin pathway	P05985	Mu or Delta receptor	PANTR|Ensembl=ENSPTRG00000000440|UniProtKB=H2PYH8	Uncharacterized protein	ISS	11259487	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00047	PDGF signaling pathway	P01160	IP3 receptor	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05923	beta-ARR2	MACMU|Ensembl=ENSMMUG00000017654|UniProtKB=F6UI32	Beta-arrestin-2 isoform 1	ISS	12464600	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00007	Axon guidance mediated by semaphorins	P00339	CRMP	RAT|RGD=2517|UniProtKB=P47942	Dihydropyrimidinase-related protein 2	ISS	7637782	PubMed	PTHR11647:SF56	DIHYDROPYRIMIDINASE-RELATED PROTEIN 2
P00048	PI3 kinase pathway	P01202	p85	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00034	Integrin signalling pathway	P00941	Integrin alpha	PANTR|Ensembl=ENSPTRG00000014748|UniProtKB=H2QMA4	Uncharacterized protein	ISS	3487386	PubMed	PTHR23220:SF69	INTEGRIN ALPHA-9
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	ANOGA|EnsemblGenome=AGAP005773|UniProtKB=A0NEH6	AGAP005773-PA	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01471	alpha-catenin	HUMAN|HGNC=2509|UniProtKB=P35221	Catenin alpha-1	IDA	1904011	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00219	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00236	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00048	PI3 kinase pathway	P01188	Gbetagamma	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00057	Wnt signaling pathway	P01428	Frizzled	RAT|RGD=71017|UniProtKB=Q9QZH0	Frizzled-4	IDA	8717036	PubMed	PTHR11309:SF23	FRIZZLED-4
P00034	Integrin signalling pathway	P00941	Integrin alpha	RAT|RGD=621634|UniProtKB=B5DEG1	Protein Itga8	ISS	10778855	PubMed	PTHR23220:SF5	INTEGRIN ALPHA-8
P00019	Endothelin signaling pathway	P00572	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8440264	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05731	GABA-B receptor II signaling	P05755	Gbeta	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MOUSE|MGI=MGI=108570|UniProtKB=Q61090	Frizzled-7	TAS	11212302	PubMed	PTHR11309:SF31	FRIZZLED-7
P00029	Huntington disease	P00796	Kainate receptor	MONDO|Ensembl=ENSMODG00000013079|UniProtKB=F7FB74	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	HUMAN|HGNC=1389|UniProtKB=Q00975	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	15079861	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00021	FGF signaling pathway	P00625	MKK3,6	BOVIN|Ensembl=ENSBTAG00000010576|UniProtKB=A4IFH7	MAP2K3 protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	DROME|FlyBase=FBgn0001991|UniProtKB=Q24270	Voltage-dependent calcium channel type D subunit alpha-1	ISS	11956331	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00054	Toll receptor signaling pathway	P01352	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00045	Notch signaling pathway	P01099	Notch	MACMU|Ensembl=ENSMMUG00000017022|UniProtKB=F7HQZ9	Uncharacterized protein	ISS	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IGI	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05913	Enkephalin release	P05976	Enkephalin	PANTR|Ensembl=ENSPTRG00000013172|UniProtKB=H2QJT9	Uncharacterized protein	ISS	131330	OMIM	PTHR11438:SF4	PROENKEPHALIN-B
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DROME|FlyBase=FBgn0003093|UniProtKB=P13678	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	IDA	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04393	Ras Pathway	P04547	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MACMU|Ensembl=ENSMMUG00000014807|UniProtKB=F6W548	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00049	Parkinson disease	P01211	ERK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	IDA	13430383	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04393	Ras Pathway	P04558	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000018059|UniProtKB=C7G3M9	Glutamate receptor, metabotropic 4	ISS	12488551	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00047	PDGF signaling pathway	P01143	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	11251832	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00018	EGF receptor signaling pathway	P00547	PP2A	RAT|RGD=3381|UniProtKB=P62716	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01154	Ras	RAT|RGD=1562829|UniProtKB=F1M2G3	Protein Rerg	ISS			PTHR24070:SF373	RAS-RELATED AND ESTROGEN-REGULATED GROWTH INHIBITOR
P02781	Threonine biosynthesis	P03189	Aspartate kinase	GLOVI|Gene=BAC89715|UniProtKB=Q7NJQ8	Aspartate kinase	ISS			PTHR21499:SF3	ASPARTOKINASE
P00010	B cell activation	P00373	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00546	GAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	227170	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00005	Angiogenesis	P00252	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12162872	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	MONDO|Ensembl=ENSMODG00000024440|UniProtKB=F7DJJ2	Muscarinic acetylcholine receptor	ISS	91373358	PubMed	PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00025	Hedgehog signaling pathway	P00692	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00053	T cell activation	P01332	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00199	JNKK1	MACMU|Ensembl=ENSMMUG00000019842|UniProtKB=F7FU91	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02913	Thymidylate synthase	ANOGA|EnsemblGenome=AGAP010457|UniProtKB=Q7QDW7	AGAP010457-PA	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P04398	p53 pathway feedback loops 2	P04654	Rb	CHICK|Gene=RB1|UniProtKB=Q90600	Retinoblastoma-associated protein	ISS			PTHR13742:SF17	RETINOBLASTOMA-ASSOCIATED PROTEIN
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00053	T cell activation	P01300	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00038	JAK/STAT signaling pathway	P01029	Serine kinase	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	ISS			PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00034	Integrin signalling pathway	P00920	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00005	Angiogenesis	P00254	GTPase	PANTR|Ensembl=ENSPTRG00000040414|UniProtKB=H2RH27	Ras homolog gene family, member B	ISS	13679859	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P04393	Ras Pathway	P04570	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	HUMAN|HGNC=4593|UniProtKB=Q13255	Metabotropic glutamate receptor 1	IDA	12488551	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00047	PDGF signaling pathway	P01151	PKB	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00364	cdc42	MACMU|Ensembl=ENSMMUG00000002924|UniProtKB=F7H1Q7	Rho-related GTP-binding protein RhoU	ISS			PTHR24072:SF148	RHO-RELATED GTP-BINDING PROTEIN RHOU
P00010	B cell activation	P00376	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00053	T cell activation	P01300	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00637	MKK4,7	PANTR|Ensembl=ENSPTRG00000010409|UniProtKB=H2RBC8	Uncharacterized protein	RCA			PTHR24361:SF387	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00020	FAS signaling pathway	P00615	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MACMU|Ensembl=ENSMMUG00000007027|UniProtKB=F7F210	Alpha-cardiac actin	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00561	STAT	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00056	VEGF signaling pathway	P01411	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Ensembl=ENSCAFG00000004381|UniProtKB=J9JH96	Uncharacterized protein	ISS			PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P04398	p53 pathway feedback loops 2	P04665	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04392	P53 pathway feedback loops 1	P04539	p53	BOVIN|Ensembl=ENSBTAG00000015460|UniProtKB=F1MKA9	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	MACMU|Ensembl=ENSMMUG00000022009|UniProtKB=F6RBZ7	Cell division control protein 42 homolog isoform 2	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00005	Angiogenesis	P00188	Ets	PANTR|Ensembl=ENSPTRG00000004466|UniProtKB=H2RCM3	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00029	Huntington disease	P00811	Arp2/3 complex	MACMU|Ensembl=ENSMMUG00000019342|UniProtKB=F6PVY4	Uncharacterized protein	ISS	12963527	gi	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00029	Huntington disease	P00799	JNK-2	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00050	Plasminogen activating cascade	P01256	uPAR	BOVIN|Ensembl=ENSBTAG00000013125|UniProtKB=Q05588	Urokinase plasminogen activator surface receptor	ISS	465002	gi	PTHR10624:SF6	UROKINASE PLASMINOGEN ACTIVATOR SURFACE RECEPTOR
P00006	Apoptosis signaling pathway	P00302	ATF	MONDO|Ensembl=ENSMODG00000009514|UniProtKB=F7EVK3	Uncharacterized protein	ISS	10207617	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00018	EGF receptor signaling pathway	P00552	Ras	DAPPU|EnsemblGenome=DAPPUDRAFT_301818|UniProtKB=E9I1I7	Putative uncharacterized protein	ISS	20148920	PubMed	PTHR24070:SF385	GTPASE HRAS
P00047	PDGF signaling pathway	P01175	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	8264585	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P02770	Pyridoxal phosphate salvage pathway	P03122	Pyridoxamine kinase	DROME|FlyBase=FBgn0085484|UniProtKB=Q7KUC2	FI04467p	ISS			PTHR10534:SF2	PYRIDOXAL KINASE
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00627	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	20331588	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00019	Endothelin signaling pathway	P00572	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00047	PDGF signaling pathway	P01142	p90RSK	XENTR|Xenbase=XB-GENE-479496|UniProtKB=F6S876	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00054	Toll receptor signaling pathway	P01375	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	HUMAN|HGNC=4583|UniProtKB=Q16478	Glutamate receptor ionotropic, kainate 5	ISS	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2850|UniProtKB=Q62758	5-hydroxytryptamine receptor 4	IDA			PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00805	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	PANTR|Ensembl=ENSPTRG00000006510|UniProtKB=H2Q8K1	Presenilin	ISS	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	NAS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00047	PDGF signaling pathway	P01151	PKB	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	10477300	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	HUMAN|HGNC=712|UniProtKB=P32121	Beta-arrestin-2	IDA	12464600	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00021	FGF signaling pathway	P00644	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00056	VEGF signaling pathway	P01415	MAPKAPK2/3	MACMU|Ensembl=ENSMMUG00000023567|UniProtKB=F7HHY8	Uncharacterized protein	ISS	10779545	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00054	Toll receptor signaling pathway	P01360	IKKbeta	RAT|RGD=621375|UniProtKB=Q9QY78	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P02761	Pantothenate biosynthesis	P03068	Pantoate-beta-alanine ligase	NEUCR|EnsemblGenome=EFNCRG00000004042|UniProtKB=Q7S8P2	Pantoate-beta-alanine ligase	ISS			PTHR21299:SF1	PANTOATE--BETA-ALANINE LIGASE
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00003	Alzheimer disease-amyloid secretase pathway	P00092	TACE	PANTR|Ensembl=ENSPTRG00000011640|UniProtKB=H2R900	Uncharacterized protein	ISS	12834808	PubMed	PTHR11905:SF171	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00010	B cell activation	P00381	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01134	cPLA2	MONDO|Ensembl=ENSMODG00000011791|UniProtKB=F7CBU9	Phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00029	Huntington disease	P00780	Microtubule	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g245773|UniProtKB=A7SJX9	Predicted protein	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00012	Cadherin signaling pathway	P00474	Wnt	ANOGA|EnsemblGenome=AGAP009734|UniProtKB=Q5TP56	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00038	JAK/STAT signaling pathway	P01027	STAT	RAT|RGD=3774|UniProtKB=P52632	Signal transducer and activator of transcription 5B	ISS	96102059	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00047	PDGF signaling pathway	P01142	p90RSK	MOUSE|MGI=MGI=104558|UniProtKB=P18653	Ribosomal protein S6 kinase alpha-1	ISS	6755374	gi	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05918	p38 MAPK pathway	P06043	ASK1	BOVIN|Ensembl=ENSBTAG00000009065|UniProtKB=F1MXH6	Uncharacterized protein	ISS	12566458	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00029	Huntington disease	P00810	GAPDH	LEIMA|EnsemblGenome=LmjF.30.2970|UniProtKB=Q4Q6Z5	Glyceraldehyde-3-phosphate dehydrogenase	ISS			PTHR10836:SF52	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED
P00019	Endothelin signaling pathway	P00570	PKA	LEIMA|EnsemblGenome=LmjF.35.4010|UniProtKB=Q9GNR4	Protein kinase A catalytic subunit isoform 1	ISS	10553940	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00057	Wnt signaling pathway	P01465	Ggamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BOVIN|Ensembl=ENSBTAG00000003762|UniProtKB=A5PJS1	GNB5 protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00047	PDGF signaling pathway	P01154	Ras	CAEEL|WormBase=WBGene00002335|UniProtKB=P22981	Ras protein let-60	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P04393	Ras Pathway	P04572	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CHICK|Ensembl=ENSGALG00000015835|UniProtKB=F1NZT2	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	MACMU|Ensembl=ENSMMUG00000013047|UniProtKB=F7H808	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06786	ERK1/2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	RCA	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00398	IP3R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	IGI	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00811	Arp2/3 complex	RAT|RGD=2155|UniProtKB=O88656	Actin-related protein 2/3 complex subunit 1B	TAS	12932731	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00029	Huntington disease	P00777	CBP	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04393	Ras Pathway	P04547	Ras	EMENI|EnsemblGenome=CADANIAG00002552|UniProtKB=Q12526	Ras-like protein	ISS	7997267	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00053	T cell activation	P01331	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00005	Angiogenesis	P00231	HSP27	CANLF|Ensembl=ENSCAFG00000010584|UniProtKB=P68280	Alpha-crystallin A chain	ISS			PTHR11527:SF36	ALPHA-CRYSTALLIN A CHAIN
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00029	Huntington disease	P00807	Actin	TRIVA|Gene=TVAG_337240|UniProtKB=P90623	Actin	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	IC	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04393	Ras Pathway	P04566	Stat 1/3	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	IDA	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05731	GABA-B receptor II signaling	P05760	AC	CANLF|Ensembl=ENSCAFG00000019237|UniProtKB=E2R4W4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF319	ADENYLATE CYCLASE TYPE 9
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CANLF|Ensembl=ENSCAFG00000007782|UniProtKB=F1PWZ2	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF358	MYOSIN-7B
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00049	Parkinson disease	P01221	Torsin A	MACMU|Ensembl=ENSMMUG00000003794|UniProtKB=F7GVH0	Uncharacterized protein	ISS	12421356	PubMed	PTHR10760:SF15	TORSIN-1A
P00056	VEGF signaling pathway	P01414	PLC-gamma	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00010	B cell activation	P00376	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00045	Notch signaling pathway	P01113	Pen-2	HUMAN|HGNC=9509|UniProtKB=P49810	Presenilin-2	IPI	12846562	PubMed	PTHR10202:SF13	PRESENILIN-2
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00006	Apoptosis signaling pathway	P00313	IKK	MACMU|Ensembl=ENSMMUG00000008351|UniProtKB=F7HRV5	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01063	CAT	DROME|FlyBase=FBgn0000303|UniProtKB=P07668	Choline O-acetyltransferase	IC	97225904	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P00010	B cell activation	P00402	Jnk	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IDA	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00046	Oxidative stress response	P01126	ATF2	HUMAN|HGNC=784|UniProtKB=P15336	Cyclic AMP-dependent transcription factor ATF-2	TAS	10664585	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00053	T cell activation	P01303	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	8235613	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00034	Integrin signalling pathway	P00942	Fyn	XENTR|Xenbase=XB-GENE-6053489|UniProtKB=F6S8L5	Tyrosine-protein kinase	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00021	FGF signaling pathway	P00643	Raf-1	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS			PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00057	Wnt signaling pathway	P01447	Dishevelled	PANTR|Ensembl=ENSPTRG00000008665|UniProtKB=H2QC24	Dishevelled, dsh homolog 2	ISS	11212302	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	RAT|RGD=620876|UniProtKB=O55193	C-C chemokine receptor type 2	ISS	12495638	PubMed	PTHR10489:SF913	C-C CHEMOKINE RECEPTOR TYPE 2
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	BOVIN|Ensembl=ENSBTAG00000013958|UniProtKB=G5E5G9	Uncharacterized protein	ISS			PTHR24361:SF345	SERINE/THREONINE-PROTEIN KINASE PAK 4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01446	Calcineurin	CANLF|Ensembl=ENSCAFG00000014818|UniProtKB=E2RJ59	Serine/threonine-protein phosphatase	ISS	12091710	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04427	5HT4 Receptor	CHICK|Ensembl=ENSGALG00000001383|UniProtKB=F1NJL4	Uncharacterized protein	ISS	12441358	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00057	Wnt signaling pathway	P01457	GBeta	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	BOVIN|Ensembl=ENSBTAG00000019210|UniProtKB=F1MJV4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=94924|UniProtKB=P61168	D(2) dopamine receptor	IDA	11861492	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P06664	Gonadotropin-releasing hormone receptor pathway	P06739	MEK1/2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	RCA	94313981	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00005	Angiogenesis	P00221	JNK1	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00025	Hedgehog signaling pathway	P00690	Cubitus interruptus	PANTR|Gene=GLI3|UniProtKB=Q5IS56	Transcriptional activator GLI3	ISS	15994174	PubMed	PTHR19818:SF5	TRANSCRIPTIONAL ACTIVATOR GLI3
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	CHICK|Ensembl=ENSGALG00000008414|UniProtKB=F1P5N3	Uncharacterized protein	ISS	11212302	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	91232861	PubMed	PTHR24070:SF385	GTPASE HRAS
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00005	Angiogenesis	P00182	p38MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	HUMAN|HGNC=240|UniProtKB=O60503	Adenylate cyclase type 9	IDA	2491850	PubMed	PTHR11920:SF319	ADENYLATE CYCLASE TYPE 9
P06664	Gonadotropin-releasing hormone receptor pathway	P06827	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	RCA	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P06664	Gonadotropin-releasing hormone receptor pathway	P06703	IGF-1R	MOUSE|MGI=MGI=96433|UniProtKB=Q60751	Insulin-like growth factor 1 receptor	RCA	6754360	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00013	Cell cycle	P00489	CdkC	HUMAN|HGNC=1589|UniProtKB=P24864	G1/S-specific cyclin-E1	RCA			PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00005	Angiogenesis	P00193	SOS-1	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IDA	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	BOVIN|Ensembl=ENSBTAG00000016198|UniProtKB=E1B8D6	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=621019|UniProtKB=Q08850	Syntaxin-4	ISS			PTHR19957:SF97	SYNTAXIN-4
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_79607|UniProtKB=C3ZHN4	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00046	Oxidative stress response	P01129	JNK1/2	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00021	FGF signaling pathway	P00637	MKK4,7	HUMAN|HGNC=6844|UniProtKB=P45985	Dual specificity mitogen-activated protein kinase kinase 4	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00549	EGF	MACMU|Ensembl=ENSMMUG00000002313|UniProtKB=F7D8Y3	Proepiregulin	ISS			PTHR10740:SF11	PROEPIREGULIN
P00037	Ionotropic glutamate receptor pathway	P01023	CaMKII	TAKRU|Ensembl=ENSTRUG00000007478|UniProtKB=H2T1I6	Uncharacterized protein	ISS	12888804	PubMed	PTHR43940:SF5	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01448	CBP	MACMU|Ensembl=ENSMMUG00000000893|UniProtKB=F6T7D0	Histone acetyltransferase p300	ISS	10664585	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00052	TGF-beta signaling pathway	P01288	FKBP12	PANTR|Ensembl=ENSPTRG00000003826|UniProtKB=H2Q3Z2	Peptidyl-prolyl cis-trans isomerase	ISS			PTHR10516:SF333	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP2
P00050	Plasminogen activating cascade	P01260	pro-MMP-3	RAT|RGD=621317|UniProtKB=P03957	Stromelysin-1	IEP	3875482	PubMed	PTHR10201:SF215	STROMELYSIN-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	PANTR|Ensembl=ENSPTRG00000021362|UniProtKB=H2QXW1	Actin-related protein 2/3 complex subunit 5	ISS	12932731	PubMed	PTHR12644:SF2	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5-LIKE PROTEIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	P00551	Akt	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	ISS	12655147	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00840	GPRK	CANLF|Ensembl=ENSCAFG00000016388|UniProtKB=F6X9W7	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00029	Huntington disease	P00786	ARF	YEAST|SGD=S000005620|UniProtKB=P40994	ADP-ribosylation factor 3	IPI	12932731	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IC	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MOUSE|MGI=MGI=1339711|UniProtKB=Q5SX40	Myosin-1	IEP	89264452	PubMed	PTHR13140:SF484	MYOSIN-1
P02777	Succinate to proprionate conversion	P03163	Methylmalonyl-CoA decarboxylase	MOUSE|MGI=MGI=1914154|UniProtKB=Q99MN9	Propionyl-CoA carboxylase beta chain, mitochondrial	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P00036	Interleukin signaling pathway	P00996	STAT	HUMAN|HGNC=11368|UniProtKB=P42226	Signal transducer and activator of transcription 6	IC	8085155	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00017	DNA replication	P00536	DNA Topisomerase	MOUSE|MGI=MGI=1920210|UniProtKB=Q8R4U6	DNA topoisomerase I, mitochondrial	ISS			PTHR10290:SF1	DNA TOPOISOMERASE I, MITOCHONDRIAL
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	IC	15860573	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	BOVIN|Ensembl=ENSBTAG00000021208|UniProtKB=E1BFQ8	Uncharacterized protein	ISS			PTHR23409:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 B
P00053	T cell activation	P01333	cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	TAS	7937853	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00019	Endothelin signaling pathway	P00587	Raf-1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00586	Gq	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	MOUSE|MGI=MGI=106684|UniProtKB=Q8R090	Chromaffin granule amine transporter	ISS	11443533	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00012	Cadherin signaling pathway	P00470	F-actin	MOUSE|MGI=MGI=2444552|UniProtKB=Q8BFZ3	Beta-actin-like protein 2	IC	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	BACSU|EnsemblGenome=BSU17460|UniProtKB=P12425	Glutamine synthetase	ISS			PTHR43785:SF1	TYPE-1 GLUTAMINE SYNTHETASE 2
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04393	Ras Pathway	P04558	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IDA	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00047	PDGF signaling pathway	P01160	IP3 receptor	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05730	Endogenous cannabinoid signaling	P05748	mGluR	MOUSE|MGI=MGI=1351342|UniProtKB=Q3UVX5	Metabotropic glutamate receptor 5	ISS	9407094	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	ORNAN|Ensembl=ENSOANG00000000493|UniProtKB=F7EPA8	Uncharacterized protein	ISS	11701344	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P05917	Opioid proopiomelanocortin pathway	P06004	Mu or Delta receptor	MOUSE|MGI=MGI=97438|UniProtKB=P32300	Delta-type opioid receptor	RCA	11259498	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00047	PDGF signaling pathway	P01162	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00006	Apoptosis signaling pathway	P00274	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02748	Isoleucine biosynthesis	P02995	Threonine dehydratase	STRCO|Gene=CAD30948|UniProtKB=Q9EWG3	Putative amino acid deaminase	ISS			PTHR43419:SF8	THREONINE AMMONIA-LYASE
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	CANLF|Ensembl=ENSCAFG00000000178|UniProtKB=J9P315	Uncharacterized protein	ISS	11907044	PubMed	PTHR44025:SF2	PROLOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000017387|UniProtKB=E2RLD1	Uncharacterized protein	ISS	12507995	PubMed	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00012	Cadherin signaling pathway	P00474	Wnt	BOVIN|Ensembl=ENSBTAG00000001668|UniProtKB=F1N6L8	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Ensembl=ENSPTRG00000016548|UniProtKB=H2QQC5	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00012	Cadherin signaling pathway	P00470	F-actin	ORNAN|Ensembl=ENSOANG00000000460|UniProtKB=F7F4W9	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00019	Endothelin signaling pathway	P00588	ET1-4	MACMU|Ensembl=ENSMMUG00000007263|UniProtKB=F7FGG2	Preproendothelin-1	ISS	12907686	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P00019	Endothelin signaling pathway	P00572	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00048	PI3 kinase pathway	P01185	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01284	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P02772	Pyruvate metabolism	P03137	Citrate Lyase	CHICK|Ensembl=ENSGALG00000003475|UniProtKB=F1P269	ATP-citrate synthase	ISS			PTHR23118:SF0	ATP-CITRATE SYNTHASE
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01143	ERK	RAT|RGD=62087|UniProtKB=P27704	Mitogen-activated protein kinase 6	ISS	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	7937853	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CAEEL|WormBase=WBGene00004969|UniProtKB=Q9TZI9	Uncharacterized protein	IC			PTHR13140:SF719	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00924	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00369	MEKK	HUMAN|HGNC=6854|UniProtKB=Q9Y2U5	Mitogen-activated protein kinase kinase kinase 2	IDA	21735556	gi	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00046	Oxidative stress response	P01122	TRX	ANOGA|EnsemblGenome=AGAP009584|UniProtKB=Q9NGZ1	Thioredoxin	TAS	12115731	PubMed	PTHR10438:SF359	THIOREDOXIN
P00052	TGF-beta signaling pathway	P01275	P38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	XENTR|Xenbase=XB-GENE-1031985|UniProtKB=Q6GL68	Transcription factor 7-like 1	ISS	11266476	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00005	Angiogenesis	P00230	PDGFR	MOUSE|MGI=MGI=97531|UniProtKB=P05622	Platelet-derived growth factor receptor beta	ISS			PTHR24416:SF53	PLATELET-DERIVED GROWTH FACTOR RECEPTOR BETA
P00007	Axon guidance mediated by semaphorins	P00341	Rho	HUMAN|HGNC=667|UniProtKB=P61586	Transforming protein RhoA	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00005	Angiogenesis	P00205	GAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	8262392	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	RAT|RGD=3693|UniProtKB=Q01818	Chromaffin granule amine transporter	ISS	11443533	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00017	DNA replication	P00534	PCNA	SULSO|EnsemblGenome=SSO0405|UniProtKB=P57765	DNA polymerase sliding clamp 3	ISS	99370062	PubMed	PTHR11352:SF0	PROLIFERATING CELL NUCLEAR ANTIGEN
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	BOVIN|Ensembl=ENSBTAG00000014828|UniProtKB=F1N1E0	Uncharacterized protein	ISS	11976940	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04395	Vasopressin synthesis	P04596	Endo Peptidase	MYCTU|EnsemblGenome=Rv0782|UniProtKB=P71834	Probable protease II PtrBb [second part] (Oligopeptidase B)	ISS			PTHR11757:SF3	PROTEASE 2
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	HUMAN|HGNC=17175|UniProtKB=Q9P212	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	12176394	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P04393	Ras Pathway	P04542	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9836512	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00055	Transcription regulation by bZIP transcription factor	P01392	TFIIH complex	YEAST|SGD=S000006043|UniProtKB=Q02939	RNA polymerase II transcription factor B subunit 2	ISS			PTHR13152:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	CHICK|Ensembl=ENSGALG00000015434|UniProtKB=F1NU20	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P04397	p53 pathway by glucose deprivation	P04636	S6K	BOVIN|Gene=RPS6KB1|UniProtKB=Q6TJY3	Ribosomal protein S6 kinase beta-1	IDA	15116068	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00049	Parkinson disease	P01219	SAPK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000002775|UniProtKB=H2RB55	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00020	FAS signaling pathway	P00604	Pro-Caspase8	PANTR|Ensembl=ENSPTRG00000012798|UniProtKB=H2R695	CASP8 and FADD-like apoptosis regulator	ISS			PTHR10454:SF8	CASP8 AND FADD-LIKE APOPTOSIS REGULATOR
P00056	VEGF signaling pathway	P01411	Ras	DANRE|ZFIN=ZDB-GENE-040808-67|UniProtKB=Q6AZA4	K-ras	ISS	10825661	PubMed	PTHR24070:SF186	GTPASE KRAS
P00046	Oxidative stress response	P01135	p38	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	8925912	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00006	Apoptosis signaling pathway	P00321	HSP70	ARATH|TAIR=AT1G16030|UniProtKB=Q9S9N1	Heat shock 70 kDa protein 5	ISS	12150907	PubMed	PTHR19375:SF321	HEAT SHOCK 70 KDA PROTEIN 5
P00012	Cadherin signaling pathway	P00470	F-actin	PHYPA|Gene=PHYPADRAFT_226658|UniProtKB=A9TYG3	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04392	P53 pathway feedback loops 1	G04686	p73	MACMU|Ensembl=ENSMMUG00000016569|UniProtKB=F6VXE7	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	IC	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P00029	Huntington disease	P00809	Caspase 6	CHICK|Ensembl=ENSGALG00000012186|UniProtKB=F1NEL6	Uncharacterized protein	IDA	10770929	PubMed	PTHR10454:SF164	CASPASE-6
P04393	Ras Pathway	P04556	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01451	Galpha	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00010	B cell activation	P00368	vav	CHICK|Ensembl=ENSGALG00000002699|UniProtKB=F1NG51	Uncharacterized protein	IGI	14623913	PubMed	PTHR22826:SF95	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV2
P06959	CCKR signaling map	P07062	CCK-G	HUMAN|HGNC=1569|UniProtKB=P06307	Cholecystokinin	RCA	12479974	PubMed	PTHR10786:SF0	CHOLECYSTOKININ
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00391	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01177	P110ACT	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00009	Axon guidance mediated by netrin	P00364	cdc42	HUMAN|HGNC=17794|UniProtKB=Q7L0Q8	Rho-related GTP-binding protein RhoU	ISS			PTHR24072:SF148	RHO-RELATED GTP-BINDING PROTEIN RHOU
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	RAT|RGD=619965|UniProtKB=P26769	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00029	Huntington disease	P00780	Microtubule	PANTR|Ensembl=ENSPTRG00000023373|UniProtKB=G2HHT2	Tubulin beta-2C chain	ISS	12932731	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00005	Angiogenesis	P00223	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	RCA			PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00005	Angiogenesis	P00193	SOS-1	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	TAS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00006	Apoptosis signaling pathway	P00260	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CAEEL|WormBase=WBGene00000065|UniProtKB=P0DM42	Actin-3	IC	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	PANTR|Gene=MYC|UniProtKB=P23583	Myc proto-oncogene protein	IEP	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00047	PDGF signaling pathway	P01169	Vav	HUMAN|HGNC=12657|UniProtKB=P15498	Proto-oncogene vav	ISS	14623913	PubMed	PTHR22826:SF112	PROTO-ONCOGENE VAV
P00015	Circadian clock system	G01501	cry	MOUSE|MGI=MGI=1270859|UniProtKB=Q9R194	Cryptochrome-2	IDA	10217146	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	DANRE|ZFIN=ZDB-GENE-051202-1|UniProtKB=E7F101	Uncharacterized protein	ISS	92049750	PubMed	PTHR44391:SF2	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00573	signal peptidase	ARATH|TAIR=AT3G15710|UniProtKB=Q9LW08	Signal peptidase I	ISS	2092035	PubMed	PTHR10806:SF6	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	188830	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00260	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00057	Wnt signaling pathway	P01435	SWI/SNF	BACSU|EnsemblGenome=BSU24580|UniProtKB=P54509	Uncharacterized ATP-dependent helicase YqhH	IDA	11532957	PubMed	PTHR10799:SF949	CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1-LIKE
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	DROME|FlyBase=FBgn0264000|UniProtKB=M9PHV5	Glutamate receptor IB, isoform B	ISS	10331083	PubMed	PTHR18966:SF270	GLUTAMATE RECEPTOR 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=15813|UniProtKB=Q9BZA8	Protocadherin-11 Y-linked	IDA	8120095	PubMed	PTHR43912:SF1	PROTOCADHERIN-11 X-LINKED-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	RCA			PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00018	EGF receptor signaling pathway	P00547	PP2A	BRAFL|Gene=BRAFLDRAFT_123893|UniProtKB=C3XQF4	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00045	Notch signaling pathway	P01103	Next	PANTR|Ensembl=ENSPTRG00000013250|UniProtKB=H2QJZ0	Delta-like protein	ISS	1286675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	TAS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00029	Huntington disease	P00780	Microtubule	MOUSE|MGI=MGI=1915201|UniProtKB=Q922F4	Tubulin beta-6 chain	IDA	12932731	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04393	Ras Pathway	P04559	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12874273	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000005792|UniProtKB=F6VTR8	Uncharacterized protein	ISS	129387	gi	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00018	EGF receptor signaling pathway	P00560	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00626	Spry	CANLF|Ensembl=ENSCAFG00000005260|UniProtKB=E2RGU9	Uncharacterized protein	ISS	12815057	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00046	Oxidative stress response	P01129	JNK1/2	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00059	p53 pathway	G04691	IGF-BP3	MACMU|Ensembl=ENSMMUG00000013764|UniProtKB=F6RF33	Uncharacterized protein	ISS			PTHR11551:SF3	INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	TAS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00005	Angiogenesis	P00196	VRAP	MOUSE|MGI=MGI=1351596|UniProtKB=Q9QXK9	SH2 domain-containing protein 2A	IDA	Q9NP31	SPACC	PTHR14388:SF9	SH2 DOMAIN-CONTAINING PROTEIN 2A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00802	PACSIN-1	CANLF|Ensembl=ENSCAFG00000001221|UniProtKB=E2RGK6	Uncharacterized protein	ISS	12354780	PubMed	PTHR23065:SF16	PROTEIN KINASE C AND CASEIN KINASE SUBSTRATE IN NEURONS PROTEIN 1
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P05913	Enkephalin release	P05977	G-Protein (s)	PANTR|Ensembl=ENSPTRG00000007084|UniProtKB=H2Q9G5	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00048	PI3 kinase pathway	P01193	IRS	HUMAN|HGNC=6125|UniProtKB=P35568	Insulin receptor substrate 1	IGI	15110093	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00048	PI3 kinase pathway	P01192	p110	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00944	Actin	MOUSE|MGI=MGI=2444552|UniProtKB=Q8BFZ3	Beta-actin-like protein 2	ISS	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00047	PDGF signaling pathway	P01173	STAT	CHICK|Ensembl=ENSGALG00000003267|UniProtKB=Q6DV79	Signal transducer and activator of transcription 3	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00920	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00004	Alzheimer disease-presenilin pathway	P00121	CD44 intracellular fragment	RAT|RGD=2307|UniProtKB=P26051	CD44 antigen	IDA	12223485	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P00019	Endothelin signaling pathway	P00570	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	TRIAD|EnsemblGenome=TriadG63380|UniProtKB=B3S653	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05918	p38 MAPK pathway	P06043	ASK1	PANTR|Ensembl=ENSPTRG00000024326|UniProtKB=H2R231	Uncharacterized protein	ISS	8974401	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00013	Cell cycle	P00480	Proteasome	RAT|RGD=1311470|UniProtKB=Q5U2S7	Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 3	ISS	4506229	gi	PTHR10758:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00019	Endothelin signaling pathway	P00572	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=69279|UniProtKB=Q9R0T4	Cadherin-1	IDA	11953314	PubMed	PTHR24027:SF319	CADHERIN-1
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MOUSE|MGI=MGI=95819|UniProtKB=P35438	Glutamate receptor ionotropic, NMDA 1	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	MACMU|Ensembl=ENSMMUG00000012305|UniProtKB=F7DLC9	Tyrosine-protein kinase receptor	ISS	2877871	PubMed	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00029	Huntington disease	P00807	Actin	DROME|FlyBase=FBgn0000043|UniProtKB=P02572	Actin-42A	ISS	10974003	PubMed	PTHR11937:SF369	ACTIN-42A
P00018	EGF receptor signaling pathway	P00539	14-3-3	RAT|RGD=3978|UniProtKB=P68511	14-3-3 protein eta	ISS	6756037	gi	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MOUSE|MGI=MGI=1913316|UniProtKB=P61953	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	ISS			PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	PANTR|Ensembl=ENSPTRG00000014845|UniProtKB=H2QMG4	Uncharacterized protein	ISS	9886417	PubMed	PTHR10489:SF711	C-C CHEMOKINE RECEPTOR TYPE 1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	TAS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_114535|UniProtKB=C3ZHN2	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	HUMAN|HGNC=1394|UniProtKB=O43497	Voltage-dependent T-type calcium channel subunit alpha-1G	IDA	14526084	PubMed	PTHR10037:SF137	VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1G
P00019	Endothelin signaling pathway	P00589	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IGI	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01319	PAK	HUMAN|HGNC=8592|UniProtKB=O75914	Serine/threonine-protein kinase PAK 3	IDA	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	MACMU|Ensembl=ENSMMUG00000000042|UniProtKB=F7HPH2	Serine/threonine-protein kinase receptor	ISS	11252892	PubMed	PTHR23255:SF64	ACTIVIN RECEPTOR TYPE-2A
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000001384|UniProtKB=F7GL73	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00019	Endothelin signaling pathway	P00591	PLCbeta	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	IC	15572354	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04547	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	91232861	PubMed	PTHR24070:SF385	GTPASE HRAS
P02772	Pyruvate metabolism	P03133	Pyruvate Dehydrogenase	ARATH|TAIR=AT1G01090|UniProtKB=O24457	Pyruvate dehydrogenase E1 component subunit alpha-3, chloroplastic	ISS	6715645	gi	PTHR11516:SF25	PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA-3, CHLOROPLASTIC
P00010	B cell activation	P00388	PLC gamma2	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000011461|UniProtKB=P28190	Adenosine receptor A1	ISS	12515326	PubMed	PTHR24246:SF1	ADENOSINE RECEPTOR A1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000012820|UniProtKB=F1MDL3	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	EMENI|EnsemblGenome=CADANIAG00002552|UniProtKB=Q12526	Ras-like protein	ISS	7997267	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00019	Endothelin signaling pathway	P00586	Gq	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00021	FGF signaling pathway	P00628	JNK1-3	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IGI	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01093	AChE	BOVIN|Ensembl=ENSBTAG00000011139|UniProtKB=P32749	Cholinesterase	ISS	87080761	PubMed	PTHR43918:SF5	CHOLINESTERASE
P00054	Toll receptor signaling pathway	P01381	Ubc13	MOUSE|MGI=MGI=1934835|UniProtKB=P61089	Ubiquitin-conjugating enzyme E2 N	ISS			PTHR43902:SF2	UBIQUITIN-CONJUGATING ENZYME E2 N
P00057	Wnt signaling pathway	P01443	Phospholipase C	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00021	FGF signaling pathway	P00644	p38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000002016|UniProtKB=F1P3G1	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g195622|UniProtKB=A7T2Q5	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04547	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00019	Endothelin signaling pathway	P00566	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00020	FAS signaling pathway	P00617	FasL	PANTR|Ensembl=ENSPTRG00000001690|UniProtKB=H2Q0M2	Uncharacterized protein	ISS	12787569	PubMed	PTHR11471:SF33	TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 6
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00878	INFgamma	CHICK|Ensembl=ENSGALG00000009903|UniProtKB=P49708	Interferon gamma	TAS	11175845	PubMed	PTHR11419:SF0	INTERFERON GAMMA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00035	Interferon-gamma signaling pathway	P00956	SOCS	CANLF|Ensembl=ENSCAFG00000015004|UniProtKB=E2RGD0	Uncharacterized protein	ISS	15032587	PubMed	PTHR44282:SF2	SUPPRESSOR OF CYTOKINE SIGNALING 4
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00049	Parkinson disease	P01211	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	IDA	98269030	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00029	Huntington disease	P00796	Kainate receptor	MACMU|Ensembl=ENSMMUG00000004886|UniProtKB=F7AGT9	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	RCA	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00005	Angiogenesis	P00246	Ang-2	RAT|RGD=621861|UniProtKB=O35462	Angiopoietin-2	ISS			PTHR19143:SF199	ANGIOPOIETIN-2
P00019	Endothelin signaling pathway	P00581	Guanylate cyclase	PANTR|Ensembl=ENSPTRG00000016541|UniProtKB=H2QQB9	Uncharacterized protein	RCA			PTHR11920:SF226	GUANYLATE CYCLASE SOLUBLE SUBUNIT ALPHA-3
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Gene=PCDHB7|UniProtKB=Q5DRC7	Protocadherin beta-7	ISS	8120095	PubMed	PTHR24028:SF69	PROTOCADHERIN BETA-7
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00005	Angiogenesis	P00218	STAT1	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	MACMU|Ensembl=ENSMMUG00000009782|UniProtKB=F6Y1Q0	C-C motif chemokine	ISS			PTHR12015:SF78	C-C MOTIF CHEMOKINE 7
P00029	Huntington disease	P00786	ARF	CANLF|Ensembl=ENSCAFG00000010433|UniProtKB=E2RNQ7	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF294	ADP-RIBOSYLATION FACTOR 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MONDO|Ensembl=ENSMODG00000020204|UniProtKB=F6SED9	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00012	Cadherin signaling pathway	P00470	F-actin	PHANO|EnsemblGenome=SNOG_01139|UniProtKB=H2KNE6	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	ARATH|TAIR=AT3G53180|UniProtKB=F4J9A0	Nodulin/glutamine synthase-like protein	ISS			PTHR43785:SF2	TYPE-1 GLUTAMINE SYNTHETASE 1
P04393	Ras Pathway	P04566	Stat 1/3	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	IDA	12191995	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P04393	Ras Pathway	P04560	AP1	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	8837781	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	IC	10747026	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	MOUSE|MGI=MGI=108007|UniProtKB=P48543	G protein-activated inward rectifier potassium channel 3	ISS	12374786	PubMed	PTHR11767:SF17	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 3
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12805548	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	TAS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	HUMAN|HGNC=4580|UniProtKB=Q13002	Glutamate receptor ionotropic, kainate 2	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9060|UniProtKB=P51178	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	7822322	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00029	Huntington disease	P00775	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	10891487	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00005	Angiogenesis	P00191	TF	PANTR|Ensembl=ENSPTRG00000000977|UniProtKB=H2R022	Tissue factor	ISS	4503641	gi	PTHR20859:SF22	TISSUE FACTOR
P00036	Interleukin signaling pathway	P00975	RasGAP	ORNAN|Ensembl=ENSOANG00000014753|UniProtKB=F7EPN2	Uncharacterized protein (Fragment)	ISS	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	IDA	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00014	Cholesterol biosynthesis	P00494	Squalene monooxygenas	ARATH|TAIR=AT2G22830|UniProtKB=O81000	Squalene epoxidase 2, mitochondrial	ISS			PTHR10835:SF0	SQUALENE MONOOXYGENASE
P00018	EGF receptor signaling pathway	P00558	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00060	Ubiquitin proteasome pathway	P01491	E2	ANOGA|EnsemblGenome=AGAP000145|UniProtKB=Q7PRY1	AGAP000145-PA	ISS			PTHR24068:SF74	FI16911P1-RELATED
P00047	PDGF signaling pathway	P01167	Ets	HUMAN|HGNC=3446|UniProtKB=P11308	Transcriptional regulator ERG	ISS	15298723	PubMed	PTHR11849:SF216	TRANSCRIPTIONAL REGULATOR ERG
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00047	PDGF signaling pathway	P01154	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000002775|UniProtKB=H2RB55	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	BOVIN|Ensembl=ENSBTAG00000004242|UniProtKB=Q1JP79	Actin-related protein 2/3 complex subunit 1A	ISS	12963527	gi	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	RAT|RGD=1309504|UniProtKB=D3ZRN3	Protein Actbl2	ISS	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00846	JAK	MOUSE|MGI=MGI=96629|UniProtKB=Q62120	Tyrosine-protein kinase JAK2	IDA	12686512	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00045	Notch signaling pathway	P01103	Next	CHICK|Ensembl=ENSGALG00000011696|UniProtKB=F1NMD6	Delta-like protein	IEP	9032054	PubMed	PTHR44097:SF1	PROTEIN JAGGED-2
P00018	EGF receptor signaling pathway	P00558	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00012	Cadherin signaling pathway	P00463	betacatenin	XENTR|Xenbase=XB-GENE-487200|UniProtKB=Q28GC2	Catenin (Cadherin associated protein), beta 1, 88kDa	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01324	rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00010	B cell activation	P00391	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	MOUSE|MGI=MGI=95814|UniProtKB=Q60934	Glutamate receptor ionotropic, kainate 1	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00021	FGF signaling pathway	P00645	Rac	ORYSJ|Gene=Os01g0229400|UniProtKB=Q9SSX0	Rac-like GTP-binding protein 1	IGI	12932731	PubMed	PTHR24072:SF154	SUBFAMILY NOT NAMED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	HUMAN|HGNC=15963|UniProtKB=Q15825	Neuronal acetylcholine receptor subunit alpha-6	IC	15155845	PubMed	PTHR18945:SF82	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-6
P00021	FGF signaling pathway	P00648	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02756	N-acetylglucosamine metabolism	P03040	N-acetylneuraminate lyase	ANOGA|EnsemblGenome=AGAP007700|UniProtKB=Q7PTG5	AGAP007700-PA	ISS			PTHR12128:SF21	N-ACETYLNEURAMINATE LYASE
P00059	p53 pathway	P04623	CBP	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P05913	Enkephalin release	P05977	G-Protein (s)	YEAST|SGD=S000005738|UniProtKB=P18851	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00540	MKK3,6	ORNAN|Ensembl=ENSOANG00000007732|UniProtKB=F6PXH5	Uncharacterized protein (Fragment)	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	EMENI|EnsemblGenome=CADANIAG00007315|UniProtKB=P20359	Actin, gamma	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	BOVIN|Ensembl=ENSBTAG00000008837|UniProtKB=P67868	Casein kinase II subunit beta	IDA	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00034	Integrin signalling pathway	P00948	Rho	MONDO|Ensembl=ENSMODG00000015141|UniProtKB=F7CZP3	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF21	RHO-RELATED GTP-BINDING PROTEIN RHON
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	129387	gi	PTHR10048:SF14	PI-3 KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	ANOGA|EnsemblGenome=AGAP001394|UniProtKB=F5HMS4	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	BOVIN|Gene=SLC18A2|UniProtKB=Q27963	Synaptic vesicular amine transporter	ISS	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CAEEL|WormBase=WBGene00001187|UniProtKB=Q8MQA1	Uncharacterized protein	IC	10514528	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00029	Huntington disease	P00780	Microtubule	SCHPO|PomBase=SPBC26H8.07c|UniProtKB=P05219	Tubulin beta chain	IDA	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00018	EGF receptor signaling pathway	P00560	Raf-1	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS			PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00019	Endothelin signaling pathway	P00566	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00036	Interleukin signaling pathway	P00987	SRF	CANLF|Ensembl=ENSCAFG00000001829|UniProtKB=F1PH12	Uncharacterized protein	ISS	15170389	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ORNAN|Ensembl=ENSOANG00000007581|UniProtKB=F6QWB7	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00057	Wnt signaling pathway	P01465	Ggamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IDA	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00056	VEGF signaling pathway	P01407	Erk	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00036	Interleukin signaling pathway	P00975	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	20908895	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00035	Interferon-gamma signaling pathway	P00957	IFNGR2	PANTR|Ensembl=ENSPTRG00000013868|UniProtKB=H2QKZ0	Interferon gamma receptor 2 (Interferon gamma transducer 1)	ISS	14525967	PubMed	PTHR20859:SF46	INTERFERON GAMMA RECEPTOR 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	97442349	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IDA	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT2G18170|UniProtKB=Q39027	Mitogen-activated protein kinase 7	ISS	11707292	PubMed	PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P04398	p53 pathway feedback loops 2	G04711	SIAH-1	CHICK|Ensembl=ENSGALG00000003916|UniProtKB=F1P2G0	E3 ubiquitin-protein ligase	ISS	14985507	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00057	Wnt signaling pathway	P01435	SWI/SNF	DROME|FlyBase=FBgn0020306|UniProtKB=Q9NDJ2	Helicase domino	IDA	11532957	PubMed	PTHR10799:SF832	HELICASE DOMINO
P00047	PDGF signaling pathway	P01162	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00025	Hedgehog signaling pathway	P00682	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	TAS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEEL|WormBase=WBGene00004033|UniProtKB=P90980	Protein kinase C-like 2	ISS	3755548	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P05918	p38 MAPK pathway	P06026	MEKK4	BOVIN|Ensembl=ENSBTAG00000020079|UniProtKB=F1N3T0	Uncharacterized protein	ISS	9305639	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00019	Endothelin signaling pathway	P00590	IP3 R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00646	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF330	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00925	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00047	PDGF signaling pathway	P01154	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P05913	Enkephalin release	P05972	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00034	Integrin signalling pathway	P00927	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00012	Cadherin signaling pathway	P00475	Frizzled	PANTR|Ensembl=ENSPTRG00000004148|UniProtKB=H2Q4I6	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF23	FRIZZLED-4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MOUSE|MGI=MGI=1278319|UniProtKB=O88536	Formyl peptide receptor 2	IC			PTHR24225:SF0	N-FORMYL PEPTIDE RECEPTOR 2
P00029	Huntington disease	P00807	Actin	SCHPO|PomBase=SPBC32H8.12c|UniProtKB=P10989	Actin	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02740	De novo pyrimidine ribonucleotides biosythesis	P02928	Dihydroorotase	THEMA|EnsemblGenome=TM_0335|UniProtKB=Q9WYH0	Dihydroorotase	ISS			PTHR43668:SF1	SUBFAMILY NOT NAMED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00010	B cell activation	P00381	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00906	Rap1	CANLF|Ensembl=ENSCAFG00000000415|UniProtKB=E2R2K4	Uncharacterized protein	ISS	1904317	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P06664	Gonadotropin-releasing hormone receptor pathway	P06700	Inhba/b	MOUSE|MGI=MGI=96571|UniProtKB=Q04999	Inhibin beta B chain	RCA			PTHR11848:SF29	INHIBIN BETA B CHAIN
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02738	De novo purine biosynthesis	P02907	dADP kinase	DICDI|dictyBase=DDB_G0273069|UniProtKB=P22887	Nucleoside diphosphate kinase, cytosolic	ISS			PTHR11349:SF64	NUCLEOSIDE DIPHOSPHATE KINASE HOMOLOG 5
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	94280860	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6880|UniProtKB=Q13164	Mitogen-activated protein kinase 7	IDA	15085193	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00056	VEGF signaling pathway	P01402	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	RCA			PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00009	Axon guidance mediated by netrin	P00359	NFAT	BOVIN|Ensembl=ENSBTAG00000018270|UniProtKB=F1MGR9	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04398	p53 pathway feedback loops 2	P04665	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00006	Apoptosis signaling pathway	P00321	HSP70	DANRE|ZFIN=ZDB-GENE-031001-11|UniProtKB=Q6P3L3	Heat shock protein 5	ISS	10934466	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02772	Pyruvate metabolism	P03140	Pyruvate Carboxylase	SCHPO|PomBase=SPBC17G9.11c|UniProtKB=Q9UUE1	Pyruvate carboxylase	NAS	1695643	gi	PTHR43778:SF2	PYRUVATE CARBOXYLASE, MITOCHONDRIAL
P00049	Parkinson disease	P01215	Syntaxin	ARATH|TAIR=AT4G17730|UniProtKB=O04378	Syntaxin-23	IPI			PTHR19957:SF38	T-SNARE DOMAIN-CONTAINING PROTEIN 1
P00057	Wnt signaling pathway	P01452	NFAT	RAT|RGD=1308692|UniProtKB=A0A0G2JTY4	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 (Predicted), isoform CRA_b	ISS	9462517	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_116948|UniProtKB=C3YKS6	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF359	SUBFAMILY NOT NAMED
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95808|UniProtKB=P23818	Glutamate receptor 1	ISS	10331083	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00057	Wnt signaling pathway	P01465	Ggamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P05915	Opioid proenkephalin pathway	P05994	G-protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04397	p53 pathway by glucose deprivation	P04647	LKB1	MOUSE|MGI=MGI=1341870|UniProtKB=Q9WTK7	Serine/threonine-protein kinase STK11	IDA	14985505	PubMed	PTHR44214:SF1	SERINE/THREONINE-PROTEIN KINASE STK11
P05915	Opioid proenkephalin pathway	P05994	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ORNAN|Ensembl=ENSOANG00000007716|UniProtKB=F6UDX9	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04395	Vasopressin synthesis	P04589	Signal Peptidase	CANLF|Ensembl=ENSCAFG00000000100|UniProtKB=P13679	Signal peptidase complex catalytic subunit SEC11C	IC	2092035	PubMed	PTHR10806:SF12	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11C
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	IDA	8946915	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	DROME|FlyBase=FBgn0264607|UniProtKB=Q00168	Calcium/calmodulin-dependent protein kinase type II alpha chain	ISS	12888804	PubMed	PTHR43940:SF1	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN
P00018	EGF receptor signaling pathway	P00562	p38	CAEBR|Gene=CBG01555|UniProtKB=A8WRD7	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	TAKRU|Ensembl=ENSTRUG00000015959|UniProtKB=H2UV27	Uncharacterized protein	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IDA	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00012	Cadherin signaling pathway	P00470	F-actin	MOUSE|MGI=MGI=87902|UniProtKB=P68134	Actin, alpha skeletal muscle	ISS	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS			PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=1339710|UniProtKB=G3UW82	MCG140437, isoform CRA_d	IC	89264452	PubMed	PTHR13140:SF385	MYOSIN-2
P02775	Salvage pyrimidine ribonucleotides	P03150	Uridine kinase	MONDO|Ensembl=ENSMODG00000017036|UniProtKB=F6Y033	Uridine kinase	ISS			PTHR10285:SF68	URIDINE-CYTIDINE KINASE-LIKE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00475	Frizzled	MONDO|Ensembl=ENSMODG00000011428|UniProtKB=F6RKF7	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF34	FRIZZLED-2
P00006	Apoptosis signaling pathway	P00318	PKCs	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00004	Alzheimer disease-presenilin pathway	P00117	E-cadherin C-terminal fragment	HUMAN|HGNC=1762|UniProtKB=P22223	Cadherin-3	IDA	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P00029	Huntington disease	P00767	Pro-caspase 8	PANTR|Ensembl=ENSPTRG00000012801|UniProtKB=H2QJ86	Caspase 8, apoptosis-related cysteine peptidase	ISS	11788820	PubMed	PTHR10454:SF162	CASPASE-8
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	CANLF|Ensembl=ENSCAFG00000015662|UniProtKB=E2RHY4	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00049	Parkinson disease	P01227	20S proteasome	YEAST|SGD=S000002979|UniProtKB=P21243	Proteasome subunit alpha type-1	TAS	12859888	PubMed	PTHR11599:SF11	PROTEASOME SUBUNIT ALPHA TYPE-6
P00018	EGF receptor signaling pathway	P00565	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	IGI	2837282	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	G04701	PML	MACMU|Ensembl=ENSMMUG00000002569|UniProtKB=F7HSN6	Uncharacterized protein	ISS	12810724	PubMed	PTHR45211:SF1	PROTEIN PML
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00010	B cell activation	P00372	Grb2	RAT|RGD=619758|UniProtKB=P62994	Growth factor receptor-bound protein 2	RCA			PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P02744	Fructose galactose metabolism	P02964	Hexose 1-P uridyltransferase	MACMU|Ensembl=ENSMMUG00000020789|UniProtKB=F7HA02	Galactose-1-phosphate uridylyltransferase	ISS	1427861	PubMed	PTHR11943:SF1	GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MONDO|Ensembl=ENSMODG00000004799|UniProtKB=F6VM87	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MACMU|Ensembl=ENSMMUG00000017374|UniProtKB=F7H6T7	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00049	Parkinson disease	P01231	gamma-Synuclein	BOVIN|Ensembl=ENSBTAG00000003515|UniProtKB=Q9NZ50	Gamma-synuclein	ISS			PTHR13820:SF10	GAMMA-SYNUCLEIN
P00037	Ionotropic glutamate receptor pathway	P01005	NR2D	RAT|RGD=2740|UniProtKB=Q62645	Glutamate receptor ionotropic, NMDA 2D	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2D.html	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	HUMAN|HGNC=16767|UniProtKB=Q8TCU5	Glutamate receptor ionotropic, NMDA 3A	ISS	11319238	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00021	FGF signaling pathway	P00643	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04393	Ras Pathway	P04558	p38	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	IDA	10995439	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00048	PI3 kinase pathway	P01202	p85	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g236559|UniProtKB=A7RRG4	Actin-related protein 2/3 complex subunit 4	ISS	9230079	PubMed	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9060|UniProtKB=P51178	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	15611108	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	TAKRU|Ensembl=ENSTRUG00000015631|UniProtKB=H2USP0	Uncharacterized protein	ISS			PTHR11681:SF14	SUBFAMILY NOT NAMED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-486685|UniProtKB=F6VT32	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00054	Toll receptor signaling pathway	P01369	MKK1	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02772	Pyruvate metabolism	P03140	Pyruvate Carboxylase	BOVIN|Ensembl=ENSBTAG00000019700|UniProtKB=Q29RK2	Pyruvate carboxylase, mitochondrial	ISS	8048912	PubMed	PTHR43778:SF2	PYRUVATE CARBOXYLASE, MITOCHONDRIAL
P00010	B cell activation	P00373	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IGI	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P06214	GBB signaling pathway	P06304	PUT	DROME|Gene=Dmel_CG7904|UniProtKB=A0A0B4KG59	Serine/threonine-protein kinase receptor	IEA	9395284	PubMed	PTHR23255:SF70	SERINE/THREONINE-PROTEIN KINASE RECEPTOR
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00759	PDEalphabeta	MACMU|Ensembl=ENSMMUG00000004752|UniProtKB=F6SMY5	Phosphodiesterase	ISS	7493036	PubMed	PTHR11347:SF115	ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00036	Interleukin signaling pathway	P00996	STAT	CANLF|Ensembl=ENSCAFG00000015213|UniProtKB=E2RB82	Signal transducer and activator of transcription	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	ARATH|TAIR=AT1G08700|UniProtKB=O64668	Presenilin-like protein At1g08700	TAS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00007	Axon guidance mediated by semaphorins	P00331	PAK	BOVIN|Ensembl=ENSBTAG00000010191|UniProtKB=Q08E52	Serine/threonine-protein kinase PAK 1	ISS	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00029	Huntington disease	P00796	Kainate receptor	MOUSE|MGI=MGI=95816|UniProtKB=B1AS29	Glutamate receptor ionotropic, kainate 3	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_127489|UniProtKB=C3XYC6	Putative uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00049	Parkinson disease	P01238	14-3-3	ORYSJ|EnsemblGenome=OS11G0546900|UniProtKB=Q2R2W2	14-3-3-like protein GF14-D	ISS	20493542	PubMed	PTHR18860:SF34	SUBFAMILY NOT NAMED
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	HUMAN|HGNC=8592|UniProtKB=O75914	Serine/threonine-protein kinase PAK 3	ISS	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00034	Integrin signalling pathway	P00920	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00006	Apoptosis signaling pathway	P00297	NFkappaB	HUMAN|HGNC=7795|UniProtKB=Q00653	Nuclear factor NF-kappa-B p100 subunit	ISS	20151924	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00029	Huntington disease	P00810	GAPDH	MACMU|Ensembl=ENSMMUG00000000837|UniProtKB=F6Q1J4	Glyceraldehyde-3-phosphate dehydrogenase	ISS			PTHR10836:SF79	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE, TESTIS-SPECIFIC
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DANRE|ZFIN=ZDB-GENE-000329-1|UniProtKB=Q7ZVI7	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00047	PDGF signaling pathway	P01143	ERK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00053	T cell activation	P01300	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01142	p90RSK	HUMAN|HGNC=10431|UniProtKB=Q15349	Ribosomal protein S6 kinase alpha-2	ISS	15526037	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00004	Alzheimer disease-presenilin pathway	P00117	E-cadherin C-terminal fragment	MOUSE|MGI=MGI=88354|UniProtKB=P09803	Cadherin-1	IDA	12834808	PubMed	PTHR24027:SF319	CADHERIN-1
P02768	Proline biosynthesis	P03112	Glutamate semialdehyde dehydrogenase	SCHPO|PomBase=SPAC821.11|UniProtKB=Q9UT44	Probable gamma-glutamyl phosphate reductase	ISS			PTHR11063:SF8	DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00583	cPLA2	BOVIN|Ensembl=ENSBTAG00000013298|UniProtKB=A4IFJ5	Cytosolic phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	IDA	11360179	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P04398	p53 pathway feedback loops 2	P04668	p53	PANTR|Ensembl=ENSPTRG00000015733|UniProtKB=H2QNY5	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00010	B cell activation	P00371	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00318	PKCs	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00006	Apoptosis signaling pathway	P00297	NFkappaB	MACMU|Ensembl=ENSMMUG00000010834|UniProtKB=F7GNW3	Uncharacterized protein	ISS			PTHR24169:SF4	PROTO-ONCOGENE C-REL
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	RAT|RGD=619966|UniProtKB=F1LQT1	Adenylate cyclase 7	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	IC	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00036	Interleukin signaling pathway	P00973	PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00644	p38	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00034	Integrin signalling pathway	P00912	Arp2/3	MACMU|Ensembl=ENSMMUG00000022808|UniProtKB=F6UWC3	Actin-related protein 2/3 complex subunit 2	ISS	12473693	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00046	Oxidative stress response	P01129	JNK1/2	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P02738	De novo purine biosynthesis	P02902	ADP reductase	MACMU|Ensembl=ENSMMUG00000003962|UniProtKB=F6Z9D7	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00056	VEGF signaling pathway	P01412	HSP27	HUMAN|HGNC=2388|UniProtKB=P02489	Alpha-crystallin A chain	IDA			PTHR11527:SF36	ALPHA-CRYSTALLIN A CHAIN
P00029	Huntington disease	P00777	CBP	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	IDA	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04393	Ras Pathway	P04556	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00583	cPLA2	RAT|RGD=67366|UniProtKB=P50393	Cytosolic phospholipase A2	IGI	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=621025|UniProtKB=Q62711	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	10934033	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00029	Huntington disease	P00778	NMDA receptor	MOUSE|MGI=MGI=95821|UniProtKB=Q01097	Glutamate receptor ionotropic, NMDA 2B	IDA	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00002	Alpha adrenergic receptor signaling pathway	P00078	Alpha1A/1B/1C	CANLF|Ensembl=ENSCAFG00000006805|UniProtKB=F1Q1Q4	Uncharacterized protein	ISS	11781138	PubMed	PTHR24248:SF26	ALPHA-2B ADRENERGIC RECEPTOR
P00052	TGF-beta signaling pathway	P01292	RSmads	MOUSE|MGI=MGI=1328787|UniProtKB=P97454	Mothers against decapentaplegic homolog 5	TAS	9395284	PubMed	PTHR13703:SF36	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5
P00047	PDGF signaling pathway	P01159	SOS	NEUCR|EnsemblGenome=EFNCRG00000006179|UniProtKB=Q7RYH5	Cell division control protein 25	ISS			PTHR23113:SF315	CELL DIVISION CONTROL PROTEIN 25-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	MACMU|Ensembl=ENSMMUG00000013450|UniProtKB=F6YGY4	Uncharacterized protein	ISS			PTHR10221:SF12	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	TAKRU|Ensembl=ENSTRUG00000015213|UniProtKB=H2UPJ1	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF356	SUBFAMILY NOT NAMED
P00035	Interferon-gamma signaling pathway	P00956	SOCS	HUMAN|HGNC=19391|UniProtKB=O14543	Suppressor of cytokine signaling 3	ISS	15032587	PubMed	PTHR44534:SF3	SUPPRESSOR OF CYTOKINE SIGNALING 3
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	HUMAN|HGNC=11839|UniProtKB=Q04726	Transducin-like enhancer protein 3	IDA	9783586	PubMed	PTHR10814:SF24	TRANSDUCIN-LIKE ENHANCER PROTEIN 3
P00018	EGF receptor signaling pathway	P00551	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00646	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	IPI	2574500	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00030	Hypoxia response via HIF activation	P00818	HIF-1alpha	BOVIN|Gene=HIF1A|UniProtKB=Q9XTA5	Hypoxia-inducible factor 1-alpha	TAS	14526383	PubMed	PTHR23043:SF7	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA
P00054	Toll receptor signaling pathway	P01381	Ubc13	DANRE|ZFIN=ZDB-GENE-040426-1291|UniProtKB=Q7T3F3	Ubiquitin-conjugating enzyme E2N-like	ISS			PTHR43902:SF2	UBIQUITIN-CONJUGATING ENZYME E2 N
P00010	B cell activation	P00384	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	ARATH|TAIR=AT5G58670|UniProtKB=Q39032	Phosphoinositide phospholipase C 1	ISS			PTHR10336:SF105	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00021	FGF signaling pathway	P00643	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P01486	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	DANRE|ZFIN=ZDB-GENE-050417-441|UniProtKB=Q567Y8	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01238	14-3-3	DANRE|ZFIN=ZDB-GENE-061023-2|UniProtKB=E7F354	Uncharacterized protein	ISS	22165492	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	TAKRU|Ensembl=ENSTRUG00000007253|UniProtKB=H2SZQ1	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF31	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	NEUCR|EnsemblGenome=EFNCRG00000000159|UniProtKB=F5HH30	Guanine nucleotide-binding protein beta subunit	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	USTMA|Gene=UMAG_03910|UniProtKB=A0A0D1DU81	Chromosome 11, whole genome shotgun sequence	ISS	10487978	PubMed	PTHR23050:SF245	AT16150P-RELATED
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	ARATH|TAIR=AT4G34460|UniProtKB=P49177	Guanine nucleotide-binding protein subunit beta	ISS	9754712	PubMed	PTHR19850:SF48	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA
P04398	p53 pathway feedback loops 2	G04715	CYCLIN G	MACMU|Ensembl=ENSMMUG00000019550|UniProtKB=F7CKQ1	Uncharacterized protein	ISS	7957050	PubMed	PTHR10177:SF59	CYCLIN-G1
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00029	Huntington disease	P00807	Actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347742|UniProtKB=E9FZ00	Cytoplasmatic actin	ISS	10974003	PubMed	PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00009	Axon guidance mediated by netrin	P00366	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00047	PDGF signaling pathway	P01164	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	11256888	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	RAT|RGD=1308692|UniProtKB=A0A0G2JTY4	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 (Predicted), isoform CRA_b	ISS	9133421	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00047	PDGF signaling pathway	P01154	Ras	MACMU|Ensembl=ENSMMUG00000010225|UniProtKB=F6S443	Ras-related protein Rab-11B	ISS			PTHR24073:SF335	RAS-RELATED PROTEIN RAB-11B
P00005	Angiogenesis	P00237	FRP	MACMU|Ensembl=ENSMMUG00000022114|UniProtKB=F7H7V5	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF81	FRIZZLED-1
P05912	Dopamine receptor mediated signaling pathway	P05970	TH	MOUSE|MGI=MGI=98735|UniProtKB=P24529	Tyrosine 3-monooxygenase	ISS	12814656	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00047	PDGF signaling pathway	P01152	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	20908895	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	AQUAE|EnsemblGenome=aq_903|UniProtKB=O67050	tRNA-specific adenosine deaminase	ISS			PTHR11079:SF149	TRNA-SPECIFIC ADENOSINE DEAMINASE
P00005	Angiogenesis	P00226	Delta/Serrate	HUMAN|HGNC=2910|UniProtKB=Q9NR61	Delta-like protein 4	IDA	11798067	PubMed	PTHR24044:SF320	DELTA-LIKE PROTEIN 4
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00052	TGF-beta signaling pathway	P01275	P38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00057	Wnt signaling pathway	P01432	Beta-Catenin	TAKRU|Ensembl=ENSTRUG00000003520|UniProtKB=H2S791	Uncharacterized protein	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CANLF|Ensembl=ENSCAFG00000019608|UniProtKB=E2R7K4	Uncharacterized protein	ISS	10391901	PubMed	PTHR15936:SF2	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-13
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00049	Parkinson disease	P01211	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04393	Ras Pathway	P04556	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	PANTR|Ensembl=ENSPTRG00000008175|UniProtKB=H2RA57	Uncharacterized protein	ISS	10617630	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P05913	Enkephalin release	P05974	G-Protein (i)	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	XENTR|Xenbase=XB-GENE-493937|UniProtKB=Q5M8T9	Actin, alpha 2, smooth muscle, aorta	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00057	Wnt signaling pathway	P01451	Galpha	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IDA	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	DROME|FlyBase=FBgn0036790|UniProtKB=Q9VVQ1	Allatostatin C receptor 1	IDA	12562507	PubMed	PTHR24229:SF51	ALLATOSTATIN C RECEPTOR 1-RELATED
P02749	Leucine biosynthesis	P03000	Branched chain amino acid aminotransferase	BACSU|EnsemblGenome=BSU38550|UniProtKB=P39576	Branched-chain-amino-acid aminotransferase 2	ISS			PTHR11825:SF44	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01292	RSmads	PANTR|Ensembl=ENSPTRG00000010005|UniProtKB=H2QEH9	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF42	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 2
P00007	Axon guidance mediated by semaphorins	P00340	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CAEBR|Gene=CBG18112|UniProtKB=A8XT20	Protein CBR-GLR-1	ISS	10331083	PubMed	PTHR18966:SF297	GLUTAMATE RECEPTOR 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01368	MKK2	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	MOUSE|MGI=MGI=1351339|UniProtKB=Q14BI2	Metabotropic glutamate receptor 2	ISS	20012997	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P02729	Ascorbate degradation	P02852	L-xylulose-5-phosphate-3-epimerase	PANTR|Ensembl=ENSPTRG00000002906|UniProtKB=Q2QD11	RcRPE (Fragment)	ISS			PTHR11749:SF6	RIBULOSE-PHOSPHATE 3-EPIMERASE-LIKE PROTEIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=109355|UniProtKB=O35526	Syntaxin-1A	ISS	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	PHYPA|Gene=PHYPADRAFT_162963|UniProtKB=A9S5I6	Predicted protein	ISS			PTHR23073:SF13	26S PROTEASE REGULATORY SUBUNIT 7
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014555|UniProtKB=F7GT55	Syntaxin-1A isoform 1	ISS	1321498	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00019	Endothelin signaling pathway	P00586	Gq	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P06587	Nicotine pharmacodynamics pathway	P06596	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8479536	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P05918	p38 MAPK pathway	P06021	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00047	PDGF signaling pathway	P01154	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00018	EGF receptor signaling pathway	P00559	MEK1-2	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IGI	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00057	Wnt signaling pathway	P01444	Wnt	RAT|RGD=1309574|UniProtKB=D3ZFS0	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF84	PROTEIN WNT-9B
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	RCA	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	ORNAN|Ensembl=ENSOANG00000004162|UniProtKB=F6UU33	Uncharacterized protein	ISS			PTHR13140:SF273	UNCONVENTIONAL MYOSIN-VA
P00013	Cell cycle	P00488	E2F	XENTR|Xenbase=XB-GENE-974737|UniProtKB=F6VW96	Uncharacterized protein	ISS	20337912	PubMed	PTHR12081:SF44	TRANSCRIPTION FACTOR E2F3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00049	Parkinson disease	P01238	14-3-3	TAKRU|Ensembl=ENSTRUG00000004697|UniProtKB=H2SFG7	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00029	Huntington disease	P00797	p53	XENTR|Xenbase=XB-GENE-1194389|UniProtKB=F7A5M9	Uncharacterized protein	ISS			PTHR12195:SF2	CYTOPLASMIC FMR1-INTERACTING PROTEIN 1
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	HUMAN|HGNC=784|UniProtKB=P15336	Cyclic AMP-dependent transcription factor ATF-2	TAS	11390664	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CANLF|Ensembl=ENSCAFG00000007690|UniProtKB=J9NYA0	Uncharacterized protein	ISS	14570579	PubMed	PTHR21230:SF26	VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1B
P00047	PDGF signaling pathway	P01171	PLCgamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00019	Endothelin signaling pathway	P00566	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00983	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00778	NMDA receptor	RAT|RGD=2740|UniProtKB=Q62645	Glutamate receptor ionotropic, NMDA 2D	IDA	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2D.html	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CRYNJ|EnsemblGenome=CNA05510|UniProtKB=Q5KNS1	cAMP-dependent protein kinase regulatory subunit	ISS	188830	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00057	Wnt signaling pathway	P01454	betaTrCP	PANTR|Ensembl=ENSPTRG00000017526|UniProtKB=H2QS02	Uncharacterized protein	ISS	12628165	PubMed	PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P00057	Wnt signaling pathway	P01457	GBeta	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MOUSE|MGI=MGI=87906|UniProtKB=P63260	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P02762	Pentose phosphate pathway	P03081	Transaldolase	BOVIN|Gene=TALDO1|UniProtKB=Q2TBL6	Transaldolase	ISS	8300619	PubMed	PTHR10683:SF18	TRANSALDOLASE
P00053	T cell activation	P01312	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	RAT|RGD=620676|UniProtKB=F1M7N7	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00046	Oxidative stress response	P01137	MNK1/2	HUMAN|HGNC=7111|UniProtKB=Q9HBH9	MAP kinase-interacting serine/threonine-protein kinase 2	IDA	11463832	PubMed	PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P00023	General transcription regulation	P00667	TFIIFbeta	MONDO|Ensembl=ENSMODG00000025484|UniProtKB=F6QZ41	General transcription factor IIF subunit 2	ISS	92020241	PubMed	PTHR10445:SF0	GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MOUSE|MGI=MGI=87909|UniProtKB=P62737	Actin, aortic smooth muscle	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00010	B cell activation	P00391	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00048	PI3 kinase pathway	P01176	JAK	HUMAN|HGNC=6192|UniProtKB=O60674	Tyrosine-protein kinase JAK2	ISS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00021	FGF signaling pathway	P00629	PP2A	BOVIN|Ensembl=ENSBTAG00000018317|UniProtKB=F1MG56	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B	ISS	11956189	PubMed	PTHR11871:SF2	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00056	VEGF signaling pathway	P01408	Akt/PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01208	Hsp70	ARATH|TAIR=AT3G12580|UniProtKB=Q9LHA8	Probable mediator of RNA polymerase II transcription subunit 37c	IDA	12150907	PubMed	PTHR19375:SF255	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 37C-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	IC	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	CAEEL|WormBase=WBGene00001680|UniProtKB=Q20636	Guanine nucleotide-binding protein subunit beta-2	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	CANLF|Ensembl=ENSCAFG00000007782|UniProtKB=F1PWZ2	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF358	MYOSIN-7B
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	PANTR|Ensembl=ENSPTRG00000003554|UniProtKB=H2Q3I3	Low density lipoprotein receptor-related protein 4	ISS	11907044	PubMed	PTHR44017:SF4	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4
P04398	p53 pathway feedback loops 2	P04661	PI3K	CAEEL|WormBase=WBGene00006932|UniProtKB=Q9TXI7	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00056	VEGF signaling pathway	P01408	Akt/PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00029	Huntington disease	P00780	Microtubule	PHYPA|Gene=PHYPADRAFT_186458|UniProtKB=Q6TYR7	Beta-tubulin 1	ISS	9454836	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000014334|UniProtKB=F7CYY6	Uncharacterized protein	ISS	11861492	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00021	FGF signaling pathway	P00648	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00048	PI3 kinase pathway	P01188	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000006495|UniProtKB=P11017	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000019904|UniProtKB=H2QVN5	Uncharacterized protein	ISS	12441358	PubMed	PTHR24247:SF108	5-HYDROXYTRYPTAMINE RECEPTOR 5A
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IPI	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00020	FAS signaling pathway	P00610	MKK4	MACMU|Ensembl=ENSMMUG00000019842|UniProtKB=F7FU91	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00049	Parkinson disease	P01235	Fyn kinase	XENTR|Xenbase=XB-GENE-6053489|UniProtKB=F6S8L5	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00046	Oxidative stress response	P01138	MKK4	MOUSE|MGI=MGI=1346875|UniProtKB=O08648	Mitogen-activated protein kinase kinase kinase 4	TAS	10207617	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00018	EGF receptor signaling pathway	P00543	ERK1-2	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	TAS	9516481	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00057	Wnt signaling pathway	P01465	Ggamma	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02762	Pentose phosphate pathway	P03079	Hexokinase	PANTR|Ensembl=ENSPTRG00000012104|UniProtKB=H2QI73	Hexokinase 2	RCA			PTHR19443:SF4	HEXOKINASE-2
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	BOVIN|Ensembl=ENSBTAG00000020873|UniProtKB=A7E3T7	S-adenosylmethionine synthase	ISS			PTHR11964:SF12	S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	DICPU|Gene=DICPUDRAFT_93216|UniProtKB=F1A421	Guanine nucleotide-binding protein subunit beta	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01173	STAT	PANTR|Ensembl=ENSPTRG00000009199|UniProtKB=H2QD19	Signal transducer and activator of transcription	ISS	95188889	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00054	Toll receptor signaling pathway	P01345	IKKalpha	RAT|RGD=1306661|UniProtKB=G3V926	Conserved helix-loop-helix ubiquitous kinase (Predicted)	ISS	12813046	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00049	Parkinson disease	P01211	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	IDA	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00047	PDGF signaling pathway	P01152	RasGAP	ORNAN|Ensembl=ENSOANG00000014753|UniProtKB=F7EPN2	Uncharacterized protein (Fragment)	ISS	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00059	p53 pathway	P01486	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P06002	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	CAEBR|Gene=CBG20206|UniProtKB=A8XX71	Protein CBR-KIN-19	ISS	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00052	TGF-beta signaling pathway	P01279	Smurfs	HUMAN|HGNC=16809|UniProtKB=Q9HAU4	E3 ubiquitin-protein ligase SMURF2	TAS	11252892	PubMed	PTHR11254:SF300	E3 UBIQUITIN-PROTEIN LIGASE SMURF2
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	CAEEL|WormBase=WBGene00006390|UniProtKB=Q7YTH5	TAF (TBP-associated transcription factor) family	ISS	604905	OMIM	PTHR12321:SF78	TAF  TBP-ASSOCIATED TRANSCRIPTION FACTOR  FAMILY
P00012	Cadherin signaling pathway	P00470	F-actin	PRIPA|Gene=PPA17339|UniProtKB=H3F5B4	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF352	ACTIN
P00034	Integrin signalling pathway	P00951	Jnk	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	IDA	8946915	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00057	Wnt signaling pathway	P01455	Smad4	MOUSE|MGI=MGI=109452|UniProtKB=P70340	Mothers against decapentaplegic homolog 1	IDA	12736218	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P00011	Blood coagulation	P00454	FVII	HUMAN|HGNC=3544|UniProtKB=P08709	Coagulation factor VII	ISS	4503645	gi	PTHR44064:SF1	COAGULATION FACTOR VII
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IPI	9514948	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	TAS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P02734	Chorismate biosynthesis	P02873	Shikimate dehydrogenase	BACTN|EnsemblGenome=BT_4215|UniProtKB=Q8A006	Shikimate 5-dehydrogenase	ISS			PTHR21089:SF1	BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE/SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00049	Parkinson disease	P01242	Casein kinase I	ARATH|TAIR=AT4G08800|UniProtKB=F4JID0	Protein kinase family protein	IDA	10617630	PubMed	PTHR11909:SF298	CASEIN KINASE 1-LIKE PROTEIN 12-RELATED
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IDA	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01162	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00047	PDGF signaling pathway	P01156	PDGF receptor B	HUMAN|HGNC=8804|UniProtKB=P09619	Platelet-derived growth factor receptor beta	RCA			PTHR24416:SF53	PLATELET-DERIVED GROWTH FACTOR RECEPTOR BETA
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P06664	Gonadotropin-releasing hormone receptor pathway	P06812	L-type Ca2+	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	RCA	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IC	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	HUMAN|HGNC=9509|UniProtKB=P49810	Presenilin-2	TAS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P06664	Gonadotropin-releasing hormone receptor pathway	P06849	Sos	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	RCA	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01160	IP3 receptor	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	RAT|RGD=621705|UniProtKB=Q8VHN2	Glutamate receptor ionotropic, NMDA 3B	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P00029	Huntington disease	P00796	Kainate receptor	DANRE|Ensembl=ENSDARG00000070511|UniProtKB=E7F5R2	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF282	GLUTAMATE RECEPTOR-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00029	Huntington disease	P00805	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00046	Oxidative stress response	P01129	JNK1/2	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	PANTR|Ensembl=ENSPTRG00000033819|UniProtKB=H2QV00	Actin related protein 2/3 complex, subunit 1A, 41kDa	ISS	12963527	gi	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00005	Angiogenesis	P00243	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04564	MAPKAP	HUMAN|HGNC=6887|UniProtKB=P49137	MAP kinase-activated protein kinase 2	IDA	9628873	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IDA	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MACMU|Ensembl=ENSMMUG00000032222|UniProtKB=F7FW05	Uncharacterized protein	ISS	14645495	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P04393	Ras Pathway	P04551	RalGDS	HUMAN|HGNC=9842|UniProtKB=Q12967	Ral guanine nucleotide dissociation stimulator	IDA	7809086	PubMed	PTHR23113:SF35	RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR
P00053	T cell activation	P01318	PKC-theta	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00048	PI3 kinase pathway	P01177	P110ACT	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00562	p38	CAEEL|WormBase=WBGene00004056|UniProtKB=Q8MXI4	Mitogen-activated protein kinase pmk-2	ISS	10851062	PubMed	PTHR24055:SF154	MITOGEN-ACTIVATED PROTEIN KINASE PMK-2
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	STRPU|EnsemblGenome=SPU_018419|UniProtKB=W4YRI6	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00057	Wnt signaling pathway	P01451	Galpha	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00064	NET	HUMAN|HGNC=11048|UniProtKB=P23975	Sodium-dependent noradrenaline transporter	ISS	97248649	PubMed	PTHR11616:SF37	SODIUM-DEPENDENT NORADRENALINE TRANSPORTER
P00056	VEGF signaling pathway	P01423	p38MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00047	PDGF signaling pathway	P01153	GSK3	DROME|FlyBase=FBgn0046332|UniProtKB=P83101	Putative glycogen synthase kinase-3 homolog	ISS	12615961	PubMed	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	CHICK|Ensembl=ENSGALG00000002098|UniProtKB=F1P0L4	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00200	Dsh	CANLF|Ensembl=ENSCAFG00000019275|UniProtKB=E2QY91	Uncharacterized protein	ISS	7906389	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	TAKRU|Ensembl=ENSTRUG00000017773|UniProtKB=H2V8M1	Uncharacterized protein (Fragment)	IDA	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P02775	Salvage pyrimidine ribonucleotides	P03149	Cytidine kinase	DANRE|ZFIN=ZDB-GENE-030131-7158|UniProtKB=Q7SYM0	Uridine-cytidine kinase 2-A	ISS			PTHR10285:SF70	URIDINE-CYTIDINE KINASE 2
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00565	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	IGI	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00010	B cell activation	P00391	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00542	EGFR	CANLF|Gene=ERBB2|UniProtKB=O18735	Receptor tyrosine-protein kinase erbB-2	ISS	4758298	gi	PTHR24416:SF137	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2
P00045	Notch signaling pathway	P01103	Next	MACMU|Ensembl=ENSMMUG00000018116|UniProtKB=F7FGM9	Delta-like protein	ISS	1286675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P04397	p53 pathway by glucose deprivation	P04637	4E-BP1	HUMAN|HGNC=3288|UniProtKB=Q13541	Eukaryotic translation initiation factor 4E-binding protein 1	IDA	12820960	PubMed	PTHR12669:SF14	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1
P00059	p53 pathway	G04693	WIP-1	PANTR|Ensembl=ENSPTRG00000009487|UniProtKB=H2RBB5	Uncharacterized protein	ISS			PTHR13832:SF359	PROTEIN PHOSPHATASE 1D
P00034	Integrin signalling pathway	P00947	Laminin	RAT|RGD=621053|UniProtKB=F1LRH4	Protein Lamc2	ISS	2538453	PubMed	PTHR10574:SF313	LAMININ SUBUNIT GAMMA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9062|UniProtKB=Q9BRC7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	10934033	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00004	Alzheimer disease-presenilin pathway	P00114	actin	XENTR|Xenbase=XB-GENE-491938|UniProtKB=Q6DIV8	Actin, alpha 1, skeletal muscle	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P02741	Flavin biosynthesis	P02934	Riboflavin kinase	RHOBA|EnsemblGenome=RB8286|UniProtKB=Q7UFW8	Riboflavin biosynthesis protein	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P00036	Interleukin signaling pathway	P00985	PDK1/2	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	ISS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00640	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IGI	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00019	Endothelin signaling pathway	P00590	IP3 R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00047	PDGF signaling pathway	P01154	Ras	EMENI|EnsemblGenome=CADANIAG00002552|UniProtKB=Q12526	Ras-like protein	ISS	7997267	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00048	PI3 kinase pathway	P01202	p85	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P05916	Opioid prodynorphin pathway	P06001	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BOVIN|Ensembl=ENSBTAG00000020267|UniProtKB=F1MKX1	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00029	Huntington disease	P00775	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00009	Axon guidance mediated by netrin	P00356	UNC-5	BOVIN|Ensembl=ENSBTAG00000010241|UniProtKB=F1MHX0	Uncharacterized protein	ISS			PTHR12582:SF5	NETRIN RECEPTOR UNC5D
P06959	CCKR signaling map	G07274	E-cadherin	HUMAN|HGNC=1748|UniProtKB=P12830	Cadherin-1	RCA		PubMed	PTHR24027:SF319	CADHERIN-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00641	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IDA	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00052	TGF-beta signaling pathway	P01285	TAK	CANLF|Ensembl=ENSCAFG00000003123|UniProtKB=E2R3R6	Uncharacterized protein	RCA			PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P00057	Wnt signaling pathway	P01431	LRP5/6	HUMAN|HGNC=6697|UniProtKB=O75197	Low-density lipoprotein receptor-related protein 5	IDA	11907044	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00006	Apoptosis signaling pathway	P00274	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	PANTR|Ensembl=ENSPTRG00000012508|UniProtKB=H2QIS5	Uncharacterized protein	ISS	11907044	PubMed	PTHR44025:SF7	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	RAT|RGD=2738|UniProtKB=Q00960	Glutamate receptor ionotropic, NMDA 2B	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00056	VEGF signaling pathway	P01425	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	2837282	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	BOVIN|Ensembl=ENSBTAG00000009702|UniProtKB=F1N775	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF368	MYOSIN-8
P00016	Cytoskeletal regulation by Rho GTPase	P00513	Op18/stathmin	CANLF|Ensembl=ENSCAFG00000029191|UniProtKB=J9NVP2	Stathmin	ISS	http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=3925	Website	PTHR10104:SF5	STATHMIN
P00047	PDGF signaling pathway	P01154	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00049	Parkinson disease	P01242	Casein kinase I	MOUSE|MGI=MGI=1351660|UniProtKB=Q9JMK2	Casein kinase I isoform epsilon	IDA	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00030	Hypoxia response via HIF activation	P00824	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	CANLF|Ensembl=ENSCAFG00000010787|UniProtKB=E2R3W6	Uncharacterized protein	ISS	11861492	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	CAEEL|WormBase=WBGene00002335|UniProtKB=P22981	Ras protein let-60	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00057	Wnt signaling pathway	P01440	Cadherin	ANOGA|Gene=AgaP_AGAP007924|UniProtKB=Q7Q3K5	AGAP007924-PA (Fragment)	IDA	8120095	PubMed	PTHR24026:SF69	PROTOCADHERIN FAT 4
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	TAS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00005	Angiogenesis	P00238	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	IC	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MOUSE|MGI=MGI=87904|UniProtKB=P60710	Actin, cytoplasmic 1	IC	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	BOVIN|Gene=PPP1CA|UniProtKB=Q3T0E7	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit	ISS	10433257	PubMed	PTHR11668:SF377	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-ALPHA CATALYTIC SUBUNIT
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	PANTR|Ensembl=ENSPTRG00000006342|UniProtKB=H2Q8A8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00029	Huntington disease	P00807	Actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	ISS	14684598	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	RAT|RGD=621440|UniProtKB=Q63511	G protein-activated inward rectifier potassium channel 3	ISS	12374786	PubMed	PTHR11767:SF17	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 3
P00057	Wnt signaling pathway	P01435	SWI/SNF	CAEEL|WormBase=WBGene00004204|UniProtKB=G5EF53	SWI/SNF nucleosome remodeling complex component	IDA	11532957	PubMed	PTHR10799:SF854	ATP-DEPENDENT HELICASE BRM
P00005	Angiogenesis	P00253	Axin	CHICK|Gene=AXIN1|UniProtKB=O42400	Axin-1	ISS	12356903	PubMed	PTHR10845:SF11	AXIN-1
P05915	Opioid proenkephalin pathway	P05994	G-protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	IDA	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00010	B cell activation	P00397	IKK	CANLF|Ensembl=ENSCAFG00000009588|UniProtKB=E2RNA9	Uncharacterized protein	ISS	12235208	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	DANRE|ZFIN=ZDB-GENE-030131-7741|UniProtKB=Q6PE34	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF93	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00627	ERK1-2	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	IGI	94131269	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	HUMAN|HGNC=4579|UniProtKB=P39086	Glutamate receptor ionotropic, kainate 1	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00052	TGF-beta signaling pathway	P01292	RSmads	DROME|FlyBase=FBgn0011648|UniProtKB=P42003	Protein mothers against dpp	TAS	12736218	PubMed	PTHR13703:SF40	PROTEIN MOTHERS AGAINST DPP
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	TAS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	DANRE|ZFIN=ZDB-GENE-040116-1|UniProtKB=Q7ZUQ0	Actin related protein 2/3 complex, subunit 1A	ISS	12932731	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00049	Parkinson disease	P01208	Hsp70	RAT|RGD=621725|UniProtKB=P63018	Heat shock cognate 71 kDa protein	IDA	12150907	PubMed	PTHR19375:SF239	HEAT SHOCK COGNATE 71 KDA PROTEIN
P00054	Toll receptor signaling pathway	P01353	TANK	MOUSE|MGI=MGI=107676|UniProtKB=P70347	TRAF family member-associated NF-kappa-B activator	ISS			PTHR15249:SF0	TRAF FAMILY MEMBER-ASSOCIATED NF-KAPPA-B ACTIVATOR
P00018	EGF receptor signaling pathway	P00562	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IGI	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	ARATH|TAIR=AT4G38530|UniProtKB=Q56W08	Phosphoinositide phospholipase C 3	ISS			PTHR10336:SF105	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	CHICK|Ensembl=ENSGALG00000010273|UniProtKB=P48463	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06743	Cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	RCA	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P02748	Isoleucine biosynthesis	P02994	Branched chain amino acid aminotransferase	PYRAE|EnsemblGenome=PAE3297|UniProtKB=Q8ZTE2	Branched-chain amino acid aminotransferase (IlvE)	ISS			PTHR42743:SF3	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE-LIKE PROTEIN 1-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	DICPU|Gene=DICPUDRAFT_93216|UniProtKB=F1A421	Guanine nucleotide-binding protein subunit beta	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04393	Ras Pathway	P04559	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	15470041	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00049	Parkinson disease	P01227	20S proteasome	ARATH|TAIR=AT5G42790|UniProtKB=P34066	Proteasome subunit alpha type-1-A	TAS	12859888	PubMed	PTHR11599:SF12	PROTEASOME SUBUNIT ALPHA TYPE-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01190	PDK1 ACT	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	IDA	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00018	EGF receptor signaling pathway	P00558	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	CANLF|Gene=PSEN1|UniProtKB=Q6RH31	Presenilin-1	ISS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00012	Cadherin signaling pathway	P00475	Frizzled	MOUSE|MGI=MGI=108476|UniProtKB=Q61086	Frizzled-3	IDA	8717036	PubMed	PTHR11309:SF22	FRIZZLED-3
P00018	EGF receptor signaling pathway	P00552	Ras	BOVIN|Ensembl=ENSBTAG00000001497|UniProtKB=A5D7L6	MRAS protein	ISS			PTHR24070:SF268	RAS-RELATED PROTEIN M-RAS
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	IC	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00059	p53 pathway	P04616	PDK1/2	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	TAS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	8946911	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00059	p53 pathway	P04622	Sin3	MONDO|Ensembl=ENSMODG00000008922|UniProtKB=F7BFR8	Uncharacterized protein	ISS	10441327	PubMed	PTHR12346:SF2	PAIRED AMPHIPATHIC HELIX PROTEIN SIN3A
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	PANTR|Ensembl=ENSPTRG00000015681|UniProtKB=H2QNU7	Dishevelled, dsh homolog 3	ISS	11212302	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P00012	Cadherin signaling pathway	P00463	betacatenin	DANRE|ZFIN=ZDB-GENE-040426-2575|UniProtKB=E7FC99	Uncharacterized protein	ISS	116806	OMIM	PTHR23315:SF68	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01198	FOXO	BOVIN|Ensembl=ENSBTAG00000011234|UniProtKB=F1N4K5	Uncharacterized protein	ISS	10102273	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01154	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	91232861	PubMed	PTHR24070:SF385	GTPASE HRAS
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00060	Ubiquitin proteasome pathway	P01491	E2	MOUSE|MGI=MGI=2384997|UniProtKB=Q91W82	Ubiquitin-conjugating enzyme E2 E2	ISS			PTHR24068:SF62	UBIQUITIN-CONJUGATING ENZYME E2 E2
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT2G18170|UniProtKB=Q39027	Mitogen-activated protein kinase 7	IDA	9836510	gi	PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P00047	PDGF signaling pathway	P01159	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00010	B cell activation	P00383	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00012	Cadherin signaling pathway	P00474	Wnt	ORNAN|Ensembl=ENSOANG00000011077|UniProtKB=F7FK62	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00006	Apoptosis signaling pathway	P00313	IKK	MACMU|Ensembl=ENSMMUG00000018476|UniProtKB=F6X938	Uncharacterized protein	ISS	12813046	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00570	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00005	Angiogenesis	P00223	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00814	P300	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00005	Angiogenesis	P00254	GTPase	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00059	p53 pathway	P04609	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00048	PI3 kinase pathway	P01179	PKB	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00552	Ras	DICPU|Gene=DICPUDRAFT_51488|UniProtKB=F1A411	Putative uncharacterized protein rasC	ISS	94119591	PubMed	PTHR24070:SF251	RAS-LIKE PROTEIN RASC
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	RAT|RGD=2061|UniProtKB=P26255	Beta-3 adrenergic receptor	IDA	11943840	PubMed	PTHR24248:SF3	BETA-3 ADRENERGIC RECEPTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	MACMU|Ensembl=ENSMMUG00000018136|UniProtKB=F7DHW8	G protein-activated inward rectifier potassium channel 2	ISS			PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	PANTR|Ensembl=ENSPTRG00000015853|UniProtKB=H2QP48	Protein-serine/threonine kinase	RCA			PTHR24355:SF14	G PROTEIN-COUPLED RECEPTOR KINASE 4
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	HUMAN|HGNC=4388|UniProtKB=P38405	Guanine nucleotide-binding protein G(olf) subunit alpha	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	MACMU|Ensembl=ENSMMUG00000021423|UniProtKB=F7EEZ1	Phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=3231|UniProtKB=Q9HCU4	Cadherin EGF LAG seven-pass G-type receptor 2	IDA	8120095	PubMed	PTHR24026:SF32	CADHERIN EGF LAG SEVEN-PASS G-TYPE RECEPTOR 2
P04393	Ras Pathway	P04563	Ets	MONDO|Ensembl=ENSMODG00000004730|UniProtKB=F6Y1Z2	Uncharacterized protein	ISS	9157999	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	CHICK|Ensembl=ENSGALG00000012511|UniProtKB=F1NCH1	Uncharacterized protein	ISS			PTHR11824:SF7	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4
P00006	Apoptosis signaling pathway	P00289	FAS	BOVIN|Ensembl=ENSBTAG00000010785|UniProtKB=P51867	Tumor necrosis factor receptor superfamily member 6	ISS	14585074	PubMed	PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00006	Apoptosis signaling pathway	P00287	TNFR2	HUMAN|HGNC=11917|UniProtKB=P20333	Tumor necrosis factor receptor superfamily member 1B	IDA	11907583	PubMed	PTHR23097:SF120	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1B
P00029	Huntington disease	P00800	PolyQ Htt	MOUSE|MGI=MGI=96067|UniProtKB=P42859	Huntingtin	TAS	7620118	PubMed	PTHR10170:SF10	HUNTINGTIN
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	TAS	8946915	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	DANRE|ZFIN=ZDB-GENE-051202-2|UniProtKB=Q6ZM67	Uncharacterized protein	ISS	14698601	PubMed	PTHR44391:SF3	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00562	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	IPI	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00049	Parkinson disease	P01227	20S proteasome	CANLF|Ensembl=ENSCAFG00000013409|UniProtKB=E2RMN2	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF11	PROTEASOME SUBUNIT ALPHA TYPE-6
P00005	Angiogenesis	P00256	PLC-gamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DICPU|Gene=DICPUDRAFT_90232|UniProtKB=F1A175	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00053	T cell activation	P01332	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01230	Src kinase	BOVIN|Ensembl=ENSBTAG00000021424|UniProtKB=Q0VBZ0	Tyrosine-protein kinase CSK	ISS	12665526	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00049	Parkinson disease	P01212	p38 MAPK	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	NAS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	MONDO|Ensembl=ENSMODG00000020977|UniProtKB=F6S5B1	Uncharacterized protein (Fragment)	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00005	Angiogenesis	P00180	Dok-R	HUMAN|HGNC=24583|UniProtKB=Q7L591	Docking protein 3	ISS			PTHR21258:SF42	DOCKING PROTEIN 3
P00048	PI3 kinase pathway	P01205	NOS	MONDO|Ensembl=ENSMODG00000003903|UniProtKB=F6S3S1	Nitric oxide synthase	ISS	9837777	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_188187|UniProtKB=E9GJ31	Guanine nucleotide binding protein, q polypeptide	ISS	1333286	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00111	C99	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01182	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00790	beta-Tubulin	RAT|RGD=628596|UniProtKB=P69897	Tubulin beta-5 chain	ISS	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00005	Angiogenesis	P00203	Erk	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Ensembl=ENSGALG00000009621|UniProtKB=P60706	Actin, cytoplasmic 1	ISS	11889139	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00054	Toll receptor signaling pathway	P01338	IkappaB	PANTR|Ensembl=ENSPTRG00000006265|UniProtKB=H2Q867	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	ISS	10811867	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00054	Toll receptor signaling pathway	P01338	IkappaB	RAT|RGD=3171|UniProtKB=Q63746	NF-kappa-B inhibitor alpha	ISS	14665694	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00052	TGF-beta signaling pathway	P01292	RSmads	CANLF|Ensembl=ENSCAFG00000017567|UniProtKB=E2RP23	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF42	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 2
P00045	Notch signaling pathway	P01107	Fringe	MOUSE|MGI=MGI=894275|UniProtKB=O09009	Beta-1,3-N-acetylglucosaminyltransferase radical fringe	IEP	9207795	PubMed	PTHR10811:SF1	BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE RADICAL FRINGE
P00005	Angiogenesis	P00190	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	8262392	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00034	Integrin signalling pathway	P00948	Rho	BOVIN|Ensembl=ENSBTAG00000039731|UniProtKB=A5PKJ7	RND3 protein	ISS	11973360	PubMed	PTHR24072:SF24	RHO-RELATED GTP-BINDING PROTEIN RHOE
P00010	B cell activation	P00397	IKK	CANLF|Ensembl=ENSCAFG00000005526|UniProtKB=E2RKR0	Uncharacterized protein	ISS	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P05918	p38 MAPK pathway	P06031	p38alpha	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	RAT|RGD=2344|UniProtKB=P08485	Muscarinic acetylcholine receptor M4	TAS	8100450	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00025	Hedgehog signaling pathway	P00682	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	BOVIN|Ensembl=ENSBTAG00000005800|UniProtKB=F1N3G8	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00054	Toll receptor signaling pathway	P01352	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IPI	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IC	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IGI	14526383	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00029	Huntington disease	P00807	Actin	ARATH|TAIR=AT5G09810|UniProtKB=P53492	Actin-7	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	TAS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05731	GABA-B receptor II signaling	P05752	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P02738	De novo purine biosynthesis	P02902	ADP reductase	MOUSE|MGI=MGI=2155865|UniProtKB=Q6PEE3	Ribonucleoside-diphosphate reductase subunit M2 B	ISS			PTHR23409:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 B
P00035	Interferon-gamma signaling pathway	P00958	PIAS	CAEEL|WormBase=WBGene00001574|UniProtKB=Q94361	E3 SUMO-protein ligase gei-17	ISS			PTHR10782:SF4	SUPPRESSOR OF VARIEGATION 2-10, ISOFORM I
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	RAT|RGD=2733|UniProtKB=P42260	Glutamate receptor ionotropic, kainate 2	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	TAS	96009592	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00005	Angiogenesis	P00189	Fzd	XENTR|Xenbase=XB-GENE-484322|UniProtKB=F6RPG1	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF22	FRIZZLED-3
P00004	Alzheimer disease-presenilin pathway	P00127	APP	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04397	p53 pathway by glucose deprivation	P04641	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00570	PKA	LEPIN|EnsemblGenome=LA_1929|UniProtKB=Q8CXT1	CAP family transcription factor	ISS	2372396	PubMed	PTHR45452:SF1	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	BOVIN|Ensembl=ENSBTAG00000005464|UniProtKB=E1B9K3	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	PANTR|Ensembl=ENSPTRG00000003946|UniProtKB=H2Q482	Protein-serine/threonine kinase	RCA			PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P02769	Purine metabolism	P03118	Guanine Deaminase	PANTR|Ensembl=ENSPTRG00000021020|UniProtKB=H2R3N5	Uncharacterized protein	ISS	11962625	PubMed	PTHR11271:SF6	GUANINE DEAMINASE
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P02746	Heme biosynthesis	P02972	Ferrochelatase	SCHPO|PomBase=SPCC320.09|UniProtKB=O59786	Ferrochelatase, mitochondrial	ISS			PTHR11108:SF1	FERROCHELATASE, MITOCHONDRIAL
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	MACMU|Ensembl=ENSMMUG00000028962|UniProtKB=F7EWG5	Uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF322	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DANRE|ZFIN=ZDB-GENE-020604-1|UniProtKB=Q6IQX1	Myosin, heavy polypeptide 2, fast muscle specific	IEP	10938134	PubMed	PTHR13140:SF676	MYOSIN, HEAVY POLYPEPTIDE 2, FAST MUSCLE SPECIFIC
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00036	Interleukin signaling pathway	P00976	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	BOVIN|Ensembl=ENSBTAG00000011283|UniProtKB=E1BDE8	Uncharacterized protein	ISS			PTHR10665:SF2	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS-LIKE PROTEIN
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02762	Pentose phosphate pathway	P03079	Hexokinase	MOUSE|MGI=MGI=96103|UniProtKB=P17710	Hexokinase-1	RCA			PTHR19443:SF10	HEXOKINASE-1
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	15621031	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00021	FGF signaling pathway	P00629	PP2A	PANTR|Ensembl=ENSPTRG00000018180|UniProtKB=H2QT14	Protein phosphatase 2, regulatory subunit B', delta	ISS	12110603	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	MONDO|Ensembl=ENSMODG00000012761|UniProtKB=F6SJA3	Tyrosine-protein kinase receptor (Fragment)	ISS	11182407	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00046	Oxidative stress response	P01137	MNK1/2	BOVIN|Ensembl=ENSBTAG00000018049|UniProtKB=E1BCH7	Uncharacterized protein	ISS	9155017	PubMed	PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	TAS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	TAS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	IXOSC|EnsemblGenome=ISCW016048|UniProtKB=B7P690	Serine hydroxymethyltransferase (Fragment)	ISS			PTHR11680:SF19	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	DANRE|ZFIN=ZDB-GENE-070705-74|UniProtKB=B8A569	Uncharacterized protein	ISS			PTHR13140:SF676	MYOSIN, HEAVY POLYPEPTIDE 2, FAST MUSCLE SPECIFIC
P00019	Endothelin signaling pathway	P00572	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IGI	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00019	Endothelin signaling pathway	P00590	IP3 R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00005	Angiogenesis	P00219	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00014	Cholesterol biosynthesis	P00496	Diphosphomevalonate decarboxylase	HUMAN|HGNC=7529|UniProtKB=P53602	Diphosphomevalonate decarboxylase	TAS	P53602	SPACC	PTHR10977:SF3	DIPHOSPHOMEVALONATE DECARBOXYLASE
P04398	p53 pathway feedback loops 2	P04654	Rb	CANLF|Ensembl=ENSCAFG00000008696|UniProtKB=E2RQ78	Uncharacterized protein	ISS			PTHR13742:SF20	RETINOBLASTOMA-LIKE PROTEIN 1
P00053	T cell activation	P01332	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MONDO|Ensembl=ENSMODG00000004799|UniProtKB=F6VM87	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	HUMAN|HGNC=4582|UniProtKB=Q16099	Glutamate receptor ionotropic, kainate 4	ISS	12778120	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	MOUSE|MGI=MGI=88296|UniProtKB=O55017	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	8386525	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00034	Integrin signalling pathway	P00936	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00020	FAS signaling pathway	P00611	Gelsolin	HUMAN|HGNC=1474|UniProtKB=P40121	Macrophage-capping protein	IGI	9323209	PubMed	PTHR11977:SF13	MACROPHAGE-CAPPING PROTEIN
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000002245|UniProtKB=H2RYC6	Uncharacterized protein (Fragment)	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00048	PI3 kinase pathway	P01192	p110	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00034	Integrin signalling pathway	P00922	Collagen	MACMU|Ensembl=ENSMMUG00000014642|UniProtKB=F7G2A9	Uncharacterized protein	ISS	10778855	PubMed	PTHR44057:SF5	COLLAGEN ALPHA-1 X  CHAIN
P06959	CCKR signaling map	P07084	MEN1	HUMAN|HGNC=7010|UniProtKB=O00255	Menin	RCA	19074642	PubMed	PTHR12693:SF3	MENIN
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	XENTR|Xenbase=XB-GENE-490883|UniProtKB=Q6NVA9	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P02723	Adenine and hypoxanthine salvage pathway	P02804	Hypoxanthine phosphoribosyl transferase	PANTR|Gene=HPRT1|UniProtKB=A5A6I1	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF6	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00056	VEGF signaling pathway	P01411	Ras	MONDO|Ensembl=ENSMODG00000025248|UniProtKB=F7F5X1	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P05913	Enkephalin release	P05977	G-Protein (s)	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01084	CHT1	CAEEL|WormBase=WBGene00004905|UniProtKB=O76689	Sodium-dependent acetylcholine transporter	IC			PTHR11616:SF158	SODIUM- AND CHLORIDE-DEPENDENT GLYCINE TRANSPORTER 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00799	JNK-2	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00006	Apoptosis signaling pathway	P00318	PKCs	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04393	Ras Pathway	P04560	AP1	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00048	PI3 kinase pathway	P01192	p110	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04398	p53 pathway feedback loops 2	P04661	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	96009592	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00049	Parkinson disease	P01219	SAPK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MOUSE|MGI=MGI=2448176|UniProtKB=Q3SXG2	Formyl peptide receptor-related sequence 6	IC			PTHR24225:SF17	FORMYL PEPTIDE RECEPTOR-RELATED SEQUENCE 6-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01072	CHT1	RAT|RGD=69270|UniProtKB=Q9JMD7	High affinity choline transporter 1	IC			PTHR11819:SF129	HIGH AFFINITY CHOLINE TRANSPORTER 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MOUSE|MGI=MGI=97255|UniProtKB=Q02566	Myosin-6	ISS	89264452	PubMed	PTHR13140:SF721	MYOSIN-6
P00029	Huntington disease	P00807	Actin	ORYSJ|EnsemblGenome=OS03G0836000|UniProtKB=Q10AZ4	Actin-3	IDA	10974003	PubMed	PTHR11937:SF254	ACTIN-1-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	CAEEL|WormBase=WBGene00004287|UniProtKB=Q94124	Ras-related protein rac-2	ISS	12932731	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	ISS	96149441	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04395	Vasopressin synthesis	P04590	Vasopressin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00009	Axon guidance mediated by netrin	P00360	DCC/UNC-40	HUMAN|HGNC=2701|UniProtKB=P43146	Netrin receptor DCC	IDA	12810718	PubMed	PTHR44146:SF3	NETRIN RECEPTOR DCC
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	ISS	10851062	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00012	Cadherin signaling pathway	P00462	Casein kinase II	HUMAN|HGNC=2459|UniProtKB=P19784	Casein kinase II subunit alpha'	ISS	10617630	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P05731	GABA-B receptor II signaling	P05760	AC	MOUSE|MGI=MGI=99673|UniProtKB=P84309	Adenylate cyclase type 5	ISS	93156838	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P02751	Lysine biosynthesis	P03009	Aspartokinase	ARATH|TAIR=AT1G31230|UniProtKB=Q9SA18	Bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic	ISS			PTHR43070:SF3	HOMOSERINE DEHYDROGENASE
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00005	Angiogenesis	P00223	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00572	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	IDA	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00006	Apoptosis signaling pathway	P00318	PKCs	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00029	Huntington disease	P00780	Microtubule	ORYSJ|EnsemblGenome=OS01G0282800|UniProtKB=Q43594	Tubulin beta-1 chain	IDA	9454836	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00981	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00021	FGF signaling pathway	P00628	JNK1-3	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IGI			PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MOUSE|MGI=MGI=1339710|UniProtKB=G3UW82	MCG140437, isoform CRA_d	ISS	89264452	PubMed	PTHR13140:SF385	MYOSIN-2
P00029	Huntington disease	P00780	Microtubule	ORNAN|Ensembl=ENSOANG00000004797|UniProtKB=F7FFR0	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	HUMAN|HGNC=4584|UniProtKB=Q05586	Glutamate receptor ionotropic, NMDA 1	IC	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	PANTR|Ensembl=ENSPTRG00000021812|UniProtKB=H2R4R8	Uncharacterized protein	ISS	11679592	PubMed	PTHR23122:SF40	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P06587	Nicotine pharmacodynamics pathway	P06613	CHRNB2	RAT|RGD=2350|UniProtKB=P12390	Neuronal acetylcholine receptor subunit beta-2	TAS	22213672	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	13620175	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00017	DNA replication	P00527	Histones	RAT|RGD=1306445|UniProtKB=D3ZJ08	Histone H3	ISS	20448842	PubMed	PTHR11426:SF161	HISTONE H3.2-RELATED
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04547	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P06959	CCKR signaling map	P07044	CDC42-GDP	HUMAN|HGNC=1736|UniProtKB=P60953	Cell division control protein 42 homolog	RCA	18565785	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00029	Huntington disease	P00775	Rac	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS			PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	IDA	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000000323|UniProtKB=H2PYA3	Uncharacterized protein	ISS	12441358	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	TAS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P02748	Isoleucine biosynthesis	P02995	Threonine dehydratase	CAEEL|WormBase=WBGene00021787|UniProtKB=Q95XY8	Uncharacterized protein	ISS			PTHR43419:SF8	THREONINE AMMONIA-LYASE
P04393	Ras Pathway	P04566	Stat 1/3	HUMAN|HGNC=11362|UniProtKB=P42224	Signal transducer and activator of transcription 1-alpha/beta	IDA	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00057	Wnt signaling pathway	P01444	Wnt	BOVIN|Ensembl=ENSBTAG00000009217|UniProtKB=F1MEW8	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IPI	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	RCA	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	RAT|RGD=1309514|UniProtKB=D4AA42	Guanine nucleotide binding protein, alpha transducing 2 (Predicted), isoform CRA_b	ISS	10188796	PubMed	PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P00052	TGF-beta signaling pathway	P01275	P38	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	TAS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	PANTR|Ensembl=ENSPTRG00000008026|UniProtKB=H2QAZ2	Syntaxin 1B	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04393	Ras Pathway	P04547	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00034	Integrin signalling pathway	P00941	Integrin alpha	MOUSE|MGI=MGI=96608|UniProtKB=P43406	Integrin alpha-V	IPI	3487386	PubMed	PTHR23220:SF4	INTEGRIN ALPHA-V
P05731	GABA-B receptor II signaling	P05752	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00189	Fzd	XENTR|Xenbase=XB-GENE-487022|UniProtKB=F6SH04	Uncharacterized protein (Fragment)	ISS	8717036	PubMed	PTHR11309:SF34	FRIZZLED-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00057	Wnt signaling pathway	P01465	Ggamma	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	IC	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P05730	Endogenous cannabinoid signaling	P05748	mGluR	MACMU|Ensembl=ENSMMUG00000010184|UniProtKB=F6SR09	Uncharacterized protein	ISS	14614461	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IC	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04542	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01407	Erk	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00046	Oxidative stress response	P01128	MEF-2	CHICK|Gene=MEF2A|UniProtKB=Q9W6U8	Myocyte-specific enhancer factor 2A	TAS	11274345	PubMed	PTHR11945:SF145	MYOCYTE-SPECIFIC ENHANCER FACTOR 2A
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	8838325	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00010	B cell activation	P00383	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02738	De novo purine biosynthesis	P02909	GDP reductase	HUMAN|HGNC=10452|UniProtKB=P31350	Ribonucleoside-diphosphate reductase subunit M2	ISS			PTHR23409:SF20	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	DROME|FlyBase=FBgn0003687|UniProtKB=P20227	TATA-box-binding protein	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00010	B cell activation	P00386	Calcineurin	PANTR|Ensembl=ENSPTRG00000016315|UniProtKB=H2QPY6	Serine/threonine-protein phosphatase	ISS	7532676	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00548	RKIP	RAT|RGD=62017|UniProtKB=P31044	Phosphatidylethanolamine-binding protein 1	IGI	12591138	PubMed	PTHR11362:SF10	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P00049	Parkinson disease	P01211	ERK	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	IDA	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00007	Axon guidance mediated by semaphorins	P00339	CRMP	RAT|RGD=2409|UniProtKB=Q62951	Dihydropyrimidinase-related protein 4 (Fragment)	ISS			PTHR11647:SF55	DIHYDROPYRIMIDINASE-RELATED PROTEIN 4
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00057	Wnt signaling pathway	P01457	GBeta	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IDA	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04373	5HT1 type receptor mediated signaling pathway	P04407	K+ channel	MACMU|Ensembl=ENSMMUG00000005826|UniProtKB=F6VE51	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00543	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	10875333	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DICPU|Gene=DICPUDRAFT_46519|UniProtKB=F0Z796	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00056	VEGF signaling pathway	P01408	Akt/PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00034	Integrin signalling pathway	P00922	Collagen	PANTR|Ensembl=ENSPTRG00000002921|UniProtKB=H2Q2J4	Uncharacterized protein	ISS	10778855	PubMed	PTHR44606:SF1	COLLAGEN ALPHA-1 XVII  CHAIN
P00048	PI3 kinase pathway	P01188	Gbetagamma	DICPU|Gene=DICPUDRAFT_93216|UniProtKB=F1A421	Guanine nucleotide-binding protein subunit beta	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	DROME|FlyBase=FBgn0027341|UniProtKB=Q7PLC7	Glutamine:fructose-6-phosphate aminotransferase 1, isoform A	ISS			PTHR10937:SF0	GH12731P-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	NEUCR|EnsemblGenome=EFNCRG00000000159|UniProtKB=F5HH30	Guanine nucleotide-binding protein beta subunit	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	20216076	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	LEIMA|EnsemblGenome=LmjF.18.1080|UniProtKB=Q27687	Protein kinase A catalytic subunit	IC	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	RAT|RGD=68385|UniProtKB=D4A055	Calcium channel, voltage-dependent, beta 4 subunit, isoform CRA_b	IC			PTHR11824:SF7	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IDA	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00224	PDGF	MACMU|Ensembl=ENSMMUG00000002739|UniProtKB=F7HKP4	Uncharacterized protein	ISS			PTHR11633:SF2	PLATELET-DERIVED GROWTH FACTOR SUBUNIT B
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	BOVIN|Ensembl=ENSBTAG00000004154|UniProtKB=E1BJ37	Uncharacterized protein	ISS	10485843	PubMed	PTHR10005:SF3	SKI-LIKE PROTEIN
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05917	Opioid proopiomelanocortin pathway	P06004	Mu or Delta receptor	RAT|RGD=3234|UniProtKB=P33535	Mu-type opioid receptor	RCA	12093103	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P04393	Ras Pathway	P04560	AP1	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	XENTR|Xenbase=XB-GENE-481916|UniProtKB=F6YF14	Presenilin	ISS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	BOVIN|Ensembl=ENSBTAG00000000219|UniProtKB=F1MCL3	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MACMU|Ensembl=ENSMMUG00000009763|UniProtKB=F6ZIC3	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF368	MYOSIN-8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	RAT|RGD=3910|UniProtKB=P04652	Thyrotropin subunit beta	ISS	3017658	PubMed	PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00005	Angiogenesis	P00243	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IPI	7937853	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00056	VEGF signaling pathway	P01417	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	DROME|FlyBase=FBgn0046332|UniProtKB=P83101	Putative glycogen synthase kinase-3 homolog	ISS	11995474	gi	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00006	Apoptosis signaling pathway	P00321	HSP70	CAEEL|WormBase=WBGene00009691|UniProtKB=G5ECU5	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF256	HSP70 PROTEIN-RELATED
P00005	Angiogenesis	P00223	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00509	Slingshot	RAT|RGD=1308679|UniProtKB=Q5XIS1	Protein phosphatase Slingshot homolog 3	ISS			PTHR10159:SF349	PROTEIN PHOSPHATASE SLINGSHOT HOMOLOG 3
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P02743	Formyltetrahydroformate biosynthesis	P02952	Methylene tetrahydrofolate dehydrogenase	MACMU|Ensembl=ENSMMUG00000019774|UniProtKB=F7G8N5	Uncharacterized protein	ISS			PTHR43274:SF3	MONOFUNCTIONAL C1-TETRAHYDROFOLATE SYNTHASE, MITOCHONDRIAL
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CANLF|Ensembl=ENSCAFG00000013148|UniProtKB=Q5R1P3	Glutamate receptor ionotropic, NMDA 2B	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04393	Ras Pathway	P04557	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00034	Integrin signalling pathway	P00924	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TAKRU|Ensembl=ENSTRUG00000005447|UniProtKB=P68142	Actin, cytoplasmic 1	IC	14684598	PubMed	PTHR11937:SF354	SUBFAMILY NOT NAMED
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00049	Parkinson disease	P01219	SAPK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05913	Enkephalin release	P05974	G-Protein (i)	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	9395335	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00574	Big ET1-4	HUMAN|HGNC=3176|UniProtKB=P05305	Endothelin-1	ISS	15117818	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P00012	Cadherin signaling pathway	P00466	EGFR	BOVIN|Ensembl=ENSBTAG00000021798|UniProtKB=F1MCQ7	Receptor protein-tyrosine kinase	ISS	4758298	gi	PTHR24416:SF137	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2
P00006	Apoptosis signaling pathway	P00291	MEKK1	MACMU|Ensembl=ENSMMUG00000012387|UniProtKB=F7EB20	Uncharacterized protein	ISS	8940199	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00126	Fe65	BOVIN|Ensembl=ENSBTAG00000027569|UniProtKB=F1MDE6	Uncharacterized protein	ISS			PTHR14058:SF11	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 2
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	RAT|RGD=621060|UniProtKB=O88777	Presenilin-2	IDA	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00036	Interleukin signaling pathway	P00977	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	MOUSE|MGI=MGI=1351660|UniProtKB=Q9JMK2	Casein kinase I isoform epsilon	ISS	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00025	Hedgehog signaling pathway	P00682	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00470	F-actin	HUMAN|HGNC=129|UniProtKB=P68133	Actin, alpha skeletal muscle	IC	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	RCA	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	NEUCR|EnsemblGenome=EFNCRG00000003893|UniProtKB=P78711	Actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P06959	CCKR signaling map	P07074	MAP2K4	HUMAN|HGNC=6844|UniProtKB=P45985	Dual specificity mitogen-activated protein kinase kinase 4	RCA	9003778	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IGI	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MACMU|Ensembl=ENSMMUG00000018853|UniProtKB=F6XSK8	Uncharacterized protein	ISS			PTHR24229:SF42	SOMATOSTATIN RECEPTOR TYPE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00049	Parkinson disease	P01219	SAPK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05915	Opioid proenkephalin pathway	P05994	G-protein	IXOSC|EnsemblGenome=ISCW009711|UniProtKB=B7Q3T6	THO complex subunit, putative	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06812	L-type Ca2+	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	RCA	9199552	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00049	Parkinson disease	P01212	p38 MAPK	DROME|FlyBase=FBgn0024846|UniProtKB=O61443	Mitogen-activated protein kinase 14B	NAS	10851062	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	MACMU|Ensembl=ENSMMUG00000017431|UniProtKB=F7HPP3	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04393	Ras Pathway	P04570	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00807	Actin	MACMU|Ensembl=ENSMMUG00000017683|UniProtKB=F6UA63	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	IDA	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P05731	GABA-B receptor II signaling	P05752	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00644	p38	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	IGI	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	SCHPO|PomBase=SPBC215.08c|UniProtKB=O94313	Carbamoyl-phosphate synthase arginine-specific large chain	ISS			PTHR11405:SF48	CARBAMOYL-PHOSPHATE SYNTHASE ARGININE-SPECIFIC LARGE CHAIN
P00021	FGF signaling pathway	P00634	MEKK1-5	BOVIN|Ensembl=ENSBTAG00000004216|UniProtKB=F1MSX4	Uncharacterized protein	ISS	8649450	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00030	Hypoxia response via HIF activation	P00814	P300	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00047	PDGF signaling pathway	P01161	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000021808|UniProtKB=Q9MZL3	Voltage-dependent L-type calcium channel subunit beta-3	IC			PTHR11824:SF8	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-3
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01443	Phospholipase C	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02730	Asparagine and aspartate biosynthesis	P02853	Asparagine synthetase	ARATH|TAIR=AT5G65010|UniProtKB=Q9LV77	Asparagine synthetase [glutamine-hydrolyzing] 2	ISS			PTHR11772:SF13	ASPARAGINE SYNTHETASE  GLUTAMINE-HYDROLYZING  2-RELATED
P00021	FGF signaling pathway	P00633	Ras	DAPPU|EnsemblGenome=DAPPUDRAFT_301818|UniProtKB=E9I1I7	Putative uncharacterized protein	ISS	20148920	PubMed	PTHR24070:SF385	GTPASE HRAS
P02744	Fructose galactose metabolism	P02964	Hexose 1-P uridyltransferase	MOUSE|MGI=MGI=95638|UniProtKB=Q03249	Galactose-1-phosphate uridylyltransferase	ISS	8400361	PubMed	PTHR11943:SF1	GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE
P00060	Ubiquitin proteasome pathway	P01491	E2	MONDO|Ensembl=ENSMODG00000006958|UniProtKB=F6QW29	Uncharacterized protein	ISS			PTHR24068:SF48	UBIQUITIN-CONJUGATING ENZYME E2 D3
P00005	Angiogenesis	P00203	Erk	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	10218114	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00021	FGF signaling pathway	P00640	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IGI	14526383	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04393	Ras Pathway	P04552	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00021	FGF signaling pathway	P00645	Rac	DICDI|dictyBase=DDB_G0293526|UniProtKB=P34149	Rho-related protein racC	ISS	94124042	PubMed	PTHR24072:SF117	RHO-RELATED PROTEIN RACC
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000008867|UniProtKB=H2QCF3	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00053	T cell activation	P01319	PAK	BOVIN|Ensembl=ENSBTAG00000015670|UniProtKB=E1B7J7	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04542	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	97442349	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01173	STAT	CANLF|Ensembl=ENSCAFG00000015213|UniProtKB=E2RB82	Signal transducer and activator of transcription	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00049	Parkinson disease	P01238	14-3-3	BOVIN|Ensembl=ENSBTAG00000000236|UniProtKB=P63103	14-3-3 protein zeta/delta	ISS	12615066	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00006	Apoptosis signaling pathway	P00311	GCKR	CAEEL|WormBase=WBGene00022603|UniProtKB=Q23290	Mitogen-activated protein kinase kinase kinase kinase	ISS			PTHR24361:SF413	HAPPYHOUR, ISOFORM A
P00040	Metabotropic glutamate receptor group II pathway	P01052	AC	MACMU|Ensembl=ENSMMUG00000010380|UniProtKB=F7D9M6	Uncharacterized protein	ISS	10915626	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P00048	PI3 kinase pathway	P01192	p110	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	ISS	96009592	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00034	Integrin signalling pathway	P00942	Fyn	CHICK|Gene=FYN|UniProtKB=Q05876	Tyrosine-protein kinase Fyn	IPI	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_126324|UniProtKB=C3XYC2	Putative uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00047	PDGF signaling pathway	P01171	PLCgamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00053	T cell activation	P01330	IKK	HUMAN|HGNC=1974|UniProtKB=O15111	Inhibitor of nuclear factor kappa-B kinase subunit alpha	IGI	12813046	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DICPU|Gene=DICPUDRAFT_48914|UniProtKB=F0ZK40	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF154	ACTIN-17-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P02749	Leucine biosynthesis	P02999	2-Isopropylmalate synthase	YEAST|SGD=S000005048|UniProtKB=P06208	2-isopropylmalate synthase	ISS			PTHR10277:SF31	2-ISOPROPYLMALATE SYNTHASE-RELATED
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00023	General transcription regulation	P00668	TFIIB	SCHPO|PomBase=SPAC16E8.16|UniProtKB=O13749	Transcription initiation factor IIB	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P04398	p53 pathway feedback loops 2	P04651	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P04393	Ras Pathway	P04569	Cdc42	TAKRU|Ensembl=ENSTRUG00000008289|UniProtKB=H2T7U8	Uncharacterized protein	ISS	11027488	PubMed	PTHR24072:SF129	CDC42L PROTEIN
P00029	Huntington disease	P00786	ARF	CHLRE|EnsemblGenome=CHLREDRAFT_186126|UniProtKB=A8IL29	Small ARF-related GTPase	IPI	12932731	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	PANTR|Ensembl=ENSPTRG00000029896|UniProtKB=H2R7Q4	Uncharacterized protein	ISS			PTHR10024:SF234	SYNAPTOTAGMIN-15
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ORNAN|Ensembl=ENSOANG00000007716|UniProtKB=F6UDX9	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	CIOIN|Ensembl=ENSCING00000008616|UniProtKB=F6T2A6	Uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00057	Wnt signaling pathway	P01443	Phospholipase C	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00053	T cell activation	P01300	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00054	Toll receptor signaling pathway	P01358	ERK1	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00022	General transcription by RNA polymerase I	P00655	UBF1	MOUSE|MGI=MGI=98512|UniProtKB=P25976	Nucleolar transcription factor 1	IGI	14612424	PubMed	PTHR13711:SF216	NUCLEOLAR TRANSCRIPTION FACTOR 1
P00057	Wnt signaling pathway	P01465	Ggamma	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04392	P53 pathway feedback loops 1	P04537	p73DeltaN	MOUSE|MGI=MGI=1330810|UniProtKB=O88898	Tumor protein 63	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	RAT|RGD=70958|UniProtKB=P19492	Glutamate receptor 3	ISS	10331083	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P04371	5-Hydroxytryptamine biosynthesis	P04400	Aromatic L-amino acid decarboxylase	ARATH|TAIR=AT4G28680|UniProtKB=Q9M0G4	Probable tyrosine decarboxylase 2	ISS			PTHR11999:SF70	MIP05841P
P00007	Axon guidance mediated by semaphorins	P00340	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05913	Enkephalin release	P05972	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	DANRE|ZFIN=ZDB-GENE-040426-2487|UniProtKB=Q803G3	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01407	Erk	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	CHICK|Ensembl=ENSGALG00000014975|UniProtKB=F1NTE9	Uncharacterized protein	ISS	11248120	PubMed	PTHR43893:SF8	D 1B  DOPAMINE RECEPTOR
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DICDI|dictyBase=DDB_G0268622|UniProtKB=P34145	Rho-related protein rac1B	ISS	12932731	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00977	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00887	IRS 1-4	MOUSE|MGI=MGI=99454|UniProtKB=P35569	Insulin receptor substrate 1	ISS	11701440	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05918	p38 MAPK pathway	P06015	p38gamma	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	4506785	gi	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00057	Wnt signaling pathway	P01443	Phospholipase C	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00047	PDGF signaling pathway	P01148	Grb2	CAEBR|Gene=CBG16856|UniProtKB=A8XPY6	Protein CBR-SEM-5	ISS	11457149	PubMed	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00040	Metabotropic glutamate receptor group II pathway	P01052	AC	MACMU|Ensembl=ENSMMUG00000010380|UniProtKB=F7D9M6	Uncharacterized protein	ISS	11744988	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00466	EGFR	MACMU|Ensembl=ENSMMUG00000020758|UniProtKB=F7HEH3	Uncharacterized protein	ISS	17432904	gi	PTHR24416:SF88	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3
P00005	Angiogenesis	P00211	GSK3beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	PANTR|Gene=HTR1F|UniProtKB=Q9N2D9	5-hydroxytryptamine receptor 1F (Fragment)	ISS	1608964	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P02775	Salvage pyrimidine ribonucleotides	P03150	Uridine kinase	BACSU|EnsemblGenome=BSU27330|UniProtKB=O32033	Uridine kinase	ISS			PTHR10285:SF6	ATP-DEPENDENT KINASE TDA10-RELATED
P04393	Ras Pathway	P04558	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00029	Huntington disease	G01533	Bax	HUMAN|HGNC=959|UniProtKB=Q07812	Apoptosis regulator BAX	ISS	11099028	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00928	alpha actinin	RAT|RGD=1308097|UniProtKB=D3ZCV0	Protein Actn2	ISS	2116421	PubMed	PTHR43947:SF4	ALPHA-ACTININ-2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00634	MEKK1-5	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS	12052864	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00018	EGF receptor signaling pathway	P00563	Gab	DROME|FlyBase=FBgn0016794|UniProtKB=Q9VZZ9	Protein daughter of sevenless	ISS			PTHR12156:SF14	PROTEIN DAUGHTER OF SEVENLESS
P02741	Flavin biosynthesis	P02935	GTP cyclohydrolase	THEMA|EnsemblGenome=TM_1826|UniProtKB=Q9X2E6	Riboflavin biosynthesis protein RibBA	ISS			PTHR21327:SF30	GTP CYCLOHYDROLASE-2
P00005	Angiogenesis	P00255	Notch	RAT|RGD=3188|UniProtKB=Q9QW30	Neurogenic locus notch homolog protein 2	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P04398	p53 pathway feedback loops 2	P04668	p53	DANRE|ZFIN=ZDB-GENE-030819-1|UniProtKB=E9QG65	Uncharacterized protein	TAS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00010	B cell activation	P00383	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00005	Angiogenesis	P00219	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00053	T cell activation	P01312	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00019	Endothelin signaling pathway	P00587	Raf-1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	RCA	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P02727	Androgen/estrogene/progesterone biosynthesis	P02830	Cholesterol esterase	MACMU|Ensembl=ENSMMUG00000022551|UniProtKB=F7EC56	Lipase	ISS	8146180	PubMed	PTHR11005:SF26	LYSOSOMAL ACID LIPASE/CHOLESTERYL ESTER HYDROLASE
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00060	Ubiquitin proteasome pathway	P01491	E2	HUMAN|HGNC=25009|UniProtKB=Q9NPD8	Ubiquitin-conjugating enzyme E2 T	ISS			PTHR44511:SF1	UBIQUITIN-CONJUGATING ENZYME E2 T
P04393	Ras Pathway	P04565	MKK4/7	BOVIN|Ensembl=ENSBTAG00000012103|UniProtKB=A5PJP8	MAP2K4 protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P02759	Pyridoxal-5-phosphate biosynthesis	P03058	Phosphohydroxythreonine aminotransferase	CAEEL|WormBase=WBGene00009177|UniProtKB=P91856	Probable phosphoserine aminotransferase	ISS			PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P00029	Huntington disease	P00807	Actin	HUMAN|HGNC=144|UniProtKB=P63261	Actin, cytoplasmic 2	IDA	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00010	B cell activation	P00379	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04397	p53 pathway by glucose deprivation	P04641	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	RAT|RGD=3694|UniProtKB=Q01827	Synaptic vesicular amine transporter	ISS	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00029	Huntington disease	P00805	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P06587	Nicotine pharmacodynamics pathway	P06605	KCNK3/9	BOVIN|Ensembl=ENSBTAG00000047488|UniProtKB=G3N1D1	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00036	Interleukin signaling pathway	P00970	Interleukin	PANTR|Ensembl=ENSPTRG00000017217|UniProtKB=H2QRG5	Uncharacterized protein	ISS			PTHR45421:SF1	INTERLEUKIN-5
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P06959	CCKR signaling map	P07086	PLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	RCA	7540841	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00006	Apoptosis signaling pathway	P00274	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00036	Interleukin signaling pathway	P00977	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00006	Apoptosis signaling pathway	P00321	HSP70	CHLRE|EnsemblGenome=CHLREDRAFT_185673|UniProtKB=A8JEU4	Heat shock protein 70A	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P02752	Mannose metabolism	P03015	GDP-Mannose 4,6-dehydratase	XENTR|Xenbase=XB-GENE-943015|UniProtKB=Q6P621	GDP-mannose 4,6-dehydratase (Fragment)	ISS	9603974	PubMed	PTHR43715:SF1	GDP-MANNOSE 4,6 DEHYDRATASE
P00047	PDGF signaling pathway	P01142	p90RSK	CHICK|Gene_ORFName=RCJMB04_14g1|UniProtKB=Q5F3L1	Ribosomal protein S6 kinase alpha-5	ISS	6755374	gi	PTHR24351:SF115	RIBOSOMAL PROTEIN S6 KINASE ALPHA-5
P00047	PDGF signaling pathway	P01154	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	DROME|FlyBase=FBgn0283499|UniProtKB=P09208	Insulin-like receptor	ISS	11943559	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P05916	Opioid prodynorphin pathway	P06002	G-protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	CIOIN|Ensembl=ENSCING00000003902|UniProtKB=Q967X2	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P02776	Serine glycine biosynthesis	P03159	Phosphoserine phosphatase	METJA|EnsemblGenome=MJ_1594|UniProtKB=Q58989	Phosphoserine phosphatase	ISS			PTHR43344:SF2	PHOSPHOSERINE PHOSPHATASE
P00050	Plasminogen activating cascade	P01246	Plasmin	MOUSE|MGI=MGI=97620|UniProtKB=P20918	Plasminogen	ISS	11928811	PubMed	PTHR24261:SF5	PLASMINOGEN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	RCA	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PHYPA|Gene=PHYPADRAFT_198730|UniProtKB=Q6TYS2	Actin 1	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00018	EGF receptor signaling pathway	P00564	Rac	ARATH|TAIR=AT2G44690|UniProtKB=Q9XGU0	Rac-like GTP-binding protein ARAC9	ISS			PTHR24072:SF160	RAC-LIKE GTP-BINDING PROTEIN ARAC9
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	MACMU|Ensembl=ENSMMUG00000023317|UniProtKB=F6Y514	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00048	PI3 kinase pathway	P01192	p110	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00034	Integrin signalling pathway	P00920	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00059	p53 pathway	P04630	PP2A	HUMAN|HGNC=9300|UniProtKB=P62714	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	RAT|RGD=3646|UniProtKB=P97884	C-C motif chemokine 20	IDA	12067311	PubMed	PTHR12015:SF108	C-C MOTIF CHEMOKINE 20
P00036	Interleukin signaling pathway	P00996	STAT	PANTR|Ensembl=ENSPTRG00000009199|UniProtKB=H2QD19	Signal transducer and activator of transcription	ISS	95188889	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00020	FAS signaling pathway	P00620	CytochromeC	TRYB2|Gene=Tb927.8.1890|UniProtKB=D6XKS6	Cytochrome c1, heme protein, mitochondrial	ISS	9027315	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ARATH|TAIR=AT2G42090|UniProtKB=P93738	Putative actin-9	IDA	10974003	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00057	Wnt signaling pathway	P01446	Calcineurin	MOUSE|MGI=MGI=107171|UniProtKB=Q63811	Calcineurin subunit B type 2	IDA	12015605	PubMed	PTHR23056:SF42	CALCINEURIN SUBUNIT B TYPE 2
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00023	General transcription regulation	P00663	TFIIFalpha	MACMU|Ensembl=ENSMMUG00000007904|UniProtKB=F6PSB1	General transcription factor IIF subunit 1	ISS	12732728	PubMed	PTHR13011:SF0	GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1
P05916	Opioid prodynorphin pathway	P06002	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00018	EGF receptor signaling pathway	P00562	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00562	p38	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	IGI	8920915	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00005	Angiogenesis	P00236	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04558	p38	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	4506785	gi	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00004	Alzheimer disease-presenilin pathway	P00118	E-cadherin	MOUSE|MGI=MGI=88354|UniProtKB=P09803	Cadherin-1	IDA	11953314	PubMed	PTHR24027:SF319	CADHERIN-1
P00059	p53 pathway	P04633	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00951	Jnk	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00049	Parkinson disease	P01208	Hsp70	RAT|RGD=1593284|UniProtKB=P0DMW0	Heat shock 70 kDa protein 1A	IDA	12150907	PubMed	PTHR19375:SF223	HEAT SHOCK 70 KDA PROTEIN 1A-RELATED
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00021	FGF signaling pathway	P00642	MEK1-2	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=12775|UniProtKB=O00744	Protein Wnt-10b	TAS	11266476	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	RCA	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P02778	Sulfate assimilation	P03167	Sulfate adenylyltransferase	MONDO|Ensembl=ENSMODG00000016494|UniProtKB=F6WHV8	Uncharacterized protein	ISS			PTHR11055:SF16	BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE 2
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P02770	Pyridoxal phosphate salvage pathway	P03120	Pyridoxamine-5-phosphate oxidase	CANLF|Ensembl=ENSCAFG00000016814|UniProtKB=E2QTE2	Uncharacterized protein	ISS	14697241	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00059	p53 pathway	P04609	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00796	Kainate receptor	ORNAN|Ensembl=ENSOANG00000002061|UniProtKB=F7ANC6	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00034	Integrin signalling pathway	P00925	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00049	Parkinson disease	P01230	Src kinase	DANRE|ZFIN=ZDB-GENE-030903-5|UniProtKB=Q6EWH2	Tyrosine-protein kinase fyna	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00037	Ionotropic glutamate receptor pathway	P01018	Glu1	DROME|FlyBase=FBgn0004619|UniProtKB=Q03445	Glutamate receptor 1	ISS	10331083	PubMed	PTHR18966:SF270	GLUTAMATE RECEPTOR 1-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04393	Ras Pathway	P04546	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	IDA	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	CAEBR|Gene=CBG18174|UniProtKB=A8XT67	Protein CBR-ARX-3	ISS	12932731	PubMed	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MOUSE|MGI=MGI=894644|UniProtKB=Q8CC27	Voltage-dependent L-type calcium channel subunit beta-2	IDA	20088160	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DANRE|ZFIN=ZDB-GENE-070112-342|UniProtKB=A1L271	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00029	Huntington disease	P00768	Apaf-1	PANTR|Ensembl=ENSPTRG00000005335|UniProtKB=H2R1S6	Apoptotic protease-activating factor 1	ISS	9267021	PubMed	PTHR22845:SF5	APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
P00020	FAS signaling pathway	P00615	JNK	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00525	N-WASP	MOUSE|MGI=MGI=1920428|UniProtKB=Q91YD9	Neural Wiskott-Aldrich syndrome protein	ISS	12932731	PubMed	PTHR23202:SF39	NEURAL WISKOTT-ALDRICH SYNDROME PROTEIN
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00049	Parkinson disease	P01211	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04570	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00364	cdc42	TAKRU|Ensembl=ENSTRUG00000008289|UniProtKB=H2T7U8	Uncharacterized protein	ISS	11027488	PubMed	PTHR24072:SF129	CDC42L PROTEIN
P00019	Endothelin signaling pathway	P00591	PLCbeta	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00047	PDGF signaling pathway	P01171	PLCgamma	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	TAS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00046	Oxidative stress response	P01138	MKK4	HUMAN|HGNC=6844|UniProtKB=P45985	Dual specificity mitogen-activated protein kinase kinase 4	TAS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CHICK|Ensembl=ENSGALG00000027629|UniProtKB=Q5ZJ03	Guanine nucleotide-binding protein subunit gamma	IC	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00018	EGF receptor signaling pathway	P00539	14-3-3	XENTR|Xenbase=XB-GENE-996375|UniProtKB=F7DY42	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00017	DNA replication	P00527	Histones	ORYSJ|EnsemblGenome=OS03G0390600|UniProtKB=Q0JCT1	Histone H3.3	ISS	12413958	PubMed	PTHR11426:SF164	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00627	ERK1-2	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	P04633	P110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06587	Nicotine pharmacodynamics pathway	P06599	EPB41L1	HUMAN|HGNC=3378|UniProtKB=Q9H4G0	Band 4.1-like protein 1	IDA	12181426	PubMed	PTHR23280:SF24	BAND 4.1-LIKE PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	PANTR|Ensembl=ENSPTRG00000014922|UniProtKB=H2QML4	Uncharacterized protein	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	HUMAN|HGNC=16844|UniProtKB=Q02930	Cyclic AMP-responsive element-binding protein 5	RCA			PTHR19304:SF8	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	HUMAN|HGNC=6205|UniProtKB=P17275	Transcription factor jun-B	ISS	10664585	PubMed	PTHR11462:SF37	TRANSCRIPTION FACTOR JUN-B
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	IC	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00057	Wnt signaling pathway	P01438	PP2A	BOVIN|Ensembl=ENSBTAG00000000469|UniProtKB=P67774	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00015	Circadian clock system	P00504	Per	MOUSE|MGI=MGI=1195265|UniProtKB=O54943	Period circadian protein homolog 2	ISS			PTHR11269:SF9	PERIOD CIRCADIAN PROTEIN HOMOLOG 2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00023	General transcription regulation	P00662	TFIIA complex	ORNAN|Ensembl=ENSOANG00000000808|UniProtKB=F6QGV9	Uncharacterized protein	ISS	600519	OMIM	PTHR12694:SF7	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1
P05731	GABA-B receptor II signaling	P05753	Ca channel	BOVIN|Ensembl=ENSBTAG00000007882|UniProtKB=G3X7Z2	Uncharacterized protein	ISS	14624853	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00547	PP2A	CANLF|Ensembl=ENSCAFG00000001753|UniProtKB=F1P714	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P02749	Leucine biosynthesis	P03002	Isopropylmalate isomerase	ECOLI|EcoGene=EG11575|UniProtKB=P30126	3-isopropylmalate dehydratase small subunit	ISS			PTHR43345:SF2	3-ISOPROPYLMALATE DEHYDRATASE SMALL SUBUNIT
P00053	T cell activation	P01322	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01236	Casein kinase II	PHYPA|Gene=PHYPADRAFT_145621|UniProtKB=A9THD0	Predicted protein	ISS	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01084	CHT1	CAEEL|WormBase=WBGene00000501|UniProtKB=O02228	High-affinity choline transporter 1	RCA			PTHR11819:SF12	HIGH-AFFINITY CHOLINE TRANSPORTER 1
P00018	EGF receptor signaling pathway	P00565	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05918	p38 MAPK pathway	P06021	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12874273	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02743	Formyltetrahydroformate biosynthesis	P02953	Cobalamin dependent homocysteine transmethylase	DROME|FlyBase=FBgn0032726|UniProtKB=Q9VJ32	FI01821p	ISS			PTHR21091:SF123	FI01821P
P04398	p53 pathway feedback loops 2	P04658	PTEN	XENTR|Xenbase=XB-GENE-491433|UniProtKB=B1H2U0	Pten protein	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00021	FGF signaling pathway	P00642	MEK1-2	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CHICK|Gene=ACTA2|UniProtKB=P08023	Actin, aortic smooth muscle	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00059	p53 pathway	G01571	FAS	HUMAN|HGNC=11920|UniProtKB=P25445	Tumor necrosis factor receptor superfamily member 6	IGI	14676844	PubMed	PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P00021	FGF signaling pathway	P00648	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00018	EGF receptor signaling pathway	P00551	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12539654	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00624	14-3-3	CHICK|Ensembl=ENSGALG00000010725|UniProtKB=Q5ZKC9	14-3-3 protein zeta	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IDA	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00197	Grb14	PANTR|Ensembl=ENSPTRG00000012587|UniProtKB=H2QIW7	Uncharacterized protein	ISS	10521483	PubMed	PTHR11243:SF22	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 14
P00004	Alzheimer disease-presenilin pathway	P00111	C99	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00036	Interleukin signaling pathway	P00983	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05915	Opioid proenkephalin pathway	P05994	G-protein	ORNAN|Ensembl=ENSOANG00000003489|UniProtKB=F7FSE3	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04393	Ras Pathway	P04578	Rho	ORNAN|Ensembl=ENSOANG00000008835|UniProtKB=F7FR08	Uncharacterized protein	ISS	13679859	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04674	Mdm2	HUMAN|HGNC=6973|UniProtKB=Q00987	E3 ubiquitin-protein ligase Mdm2	IGI	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT1G01560|UniProtKB=Q9LMM5	Mitogen-activated protein kinase 11	ISS	9836510	gi	PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MACMU|Ensembl=ENSMMUG00000009778|UniProtKB=F6Y1M7	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF385	MYOSIN-2
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	ORNAN|Ensembl=ENSOANG00000015652|UniProtKB=F7FY70	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	HALSA|EnsemblGenome=VNG_1644G|UniProtKB=Q9HPG8	Ribonucleoside reductase large chain	ISS			PTHR43371:SF1	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	RAT|RGD=71098|UniProtKB=P97633	Casein kinase I isoform alpha	IDA	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P05913	Enkephalin release	P05971	CREB	RAT|RGD=620218|UniProtKB=P15337	Cyclic AMP-responsive element-binding protein 1	ISS	11390664	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	G01571	FAS	HUMAN|HGNC=11920|UniProtKB=P25445	Tumor necrosis factor receptor superfamily member 6	IGI	1375228	PubMed	PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P04393	Ras Pathway	P04557	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	IDA	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	BOVIN|Ensembl=ENSBTAG00000019986|UniProtKB=P35508	Casein kinase I isoform delta	ISS	11437445	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000005917|UniProtKB=F6QM53	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00059	p53 pathway	G01579	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00057	Wnt signaling pathway	P01446	Calcineurin	YEAST|SGD=S000004521|UniProtKB=P14747	Serine/threonine-protein phosphatase 2B catalytic subunit A2	IDA	12015605	PubMed	PTHR11668:SF118	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED
P00005	Angiogenesis	P00185	JAK1	CANLF|Ensembl=ENSCAFG00000018615|UniProtKB=F1PIY7	Tyrosine-protein kinase	ISS	9637709	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DROME|FlyBase=FBgn0004921|UniProtKB=P38040	Guanine nucleotide-binding protein subunit gamma-1	IC			PTHR13809:SF3	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA-RELATED
P00010	B cell activation	P00367	NFAT	MACMU|Ensembl=ENSMMUG00000012657|UniProtKB=F7E7J1	Uncharacterized protein	ISS	12787506	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	IC	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05918	p38 MAPK pathway	P06031	p38alpha	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00020	FAS signaling pathway	P00599	Caspase3	DANRE|ZFIN=ZDB-GENE-011210-1|UniProtKB=B8JK21	Uncharacterized protein	IGI	11675509	PubMed	PTHR10454:SF198	CASPASE-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	TAS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	PANTR|Ensembl=ENSPTRG00000018684|UniProtKB=C7G3M7	Glutamate receptor, metabotropic 1	ISS	12351712	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P04397	p53 pathway by glucose deprivation	G04706	TSC2	MOUSE|MGI=MGI=102548|UniProtKB=Q61037	Tuberin	IDA	15249583	PubMed	PTHR10063:SF0	TUBERIN
P02783	Tryptophan biosynthesis	P03208	Tryptophan synthase B	THEMA|EnsemblGenome=TM_0138|UniProtKB=P50909	Tryptophan synthase beta chain 1	ISS			PTHR42882:SF1	TRYPTOPHAN SYNTHASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00049	Parkinson disease	P01236	Casein kinase II	DAPPU|EnsemblGenome=DAPPUDRAFT_223674|UniProtKB=E9GCV0	Putative uncharacterized protein	ISS	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00578	eNOS	RAT|RGD=3186|UniProtKB=Q62600	Nitric oxide synthase, endothelial	ISS	9837777	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00020	FAS signaling pathway	P00609	FAF1	RAT|RGD=70987|UniProtKB=Q924K2	FAS-associated factor 1	IGI	8524870	PubMed	PTHR23322:SF52	FAS-ASSOCIATED FACTOR 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00057	Wnt signaling pathway	P01431	LRP5/6	BOVIN|Ensembl=ENSBTAG00000011761|UniProtKB=F1MDE1	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00034	Integrin signalling pathway	P00927	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00029	Huntington disease	P00790	beta-Tubulin	MACMU|Ensembl=ENSMMUG00000032572|UniProtKB=F7D7Y7	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12912997	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P05916	Opioid prodynorphin pathway	P06002	G-protein	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MOUSE|MGI=MGI=95823|UniProtKB=Q03391	Glutamate receptor ionotropic, NMDA 2D	IC	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	NEUCR|EnsemblGenome=EFNCRG00000000159|UniProtKB=F5HH30	Guanine nucleotide-binding protein beta subunit	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	RAT|RGD=621789|UniProtKB=P70539	Activin receptor type-1C	IDA			PTHR23255:SF58	ACTIVIN RECEPTOR TYPE-1C
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000002245|UniProtKB=H2RYC6	Uncharacterized protein (Fragment)	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P05918	p38 MAPK pathway	P06034	MKK4	HUMAN|HGNC=6844|UniProtKB=P45985	Dual specificity mitogen-activated protein kinase kinase 4	IDA	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00018	EGF receptor signaling pathway	P00562	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	IPI	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00572	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=1762|UniProtKB=P22223	Cadherin-3	IDA	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P00048	PI3 kinase pathway	P01199	Galpha	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00052	TGF-beta signaling pathway	P01279	Smurfs	MONDO|Ensembl=ENSMODG00000001079|UniProtKB=F7GHZ3	Uncharacterized protein	ISS	11252892	PubMed	PTHR11254:SF293	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00049	Parkinson disease	P01211	ERK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	IDA	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00025	Hedgehog signaling pathway	P00682	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05960	VAT2	BOVIN|Gene=SLC18A2|UniProtKB=Q27963	Synaptic vesicular amine transporter	ISS	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00029	Huntington disease	G01535	PIG3	GLOVI|Gene=BAC90800|UniProtKB=Q7NCW7	Glr2859 protein	TAS	12932731	PubMed	PTHR43677:SF4	QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2
P00006	Apoptosis signaling pathway	P00280	PACT	BOVIN|Ensembl=ENSBTAG00000001096|UniProtKB=Q2HJ92	Interferon-inducible double-stranded RNA-dependent protein kinase activator A	ISS	10988289	PubMed	PTHR10910:SF8	INTERFERON-INDUCIBLE DOUBLE-STRANDED RNA-DEPENDENT PROTEIN KINASE ACTIVATOR A
P00057	Wnt signaling pathway	P01457	GBeta	CAEEL|WormBase=WBGene00001679|UniProtKB=P17343	Guanine nucleotide-binding protein subunit beta-1	IDA	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	DANRE|ZFIN=ZDB-GENE-030729-1|UniProtKB=B3DGN0	Opioid receptor, kappa 1	IDA	11259487	PubMed	PTHR24229:SF1	KAPPA-TYPE OPIOID RECEPTOR
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MACMU|Ensembl=ENSMMUG00000011029|UniProtKB=F7DCY3	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00010	B cell activation	P00402	Jnk	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04559	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	21244534	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00057	Wnt signaling pathway	P01431	LRP5/6	MOUSE|MGI=MGI=1298218|UniProtKB=O88572	Low-density lipoprotein receptor-related protein 6	IDA	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00049	Parkinson disease	P01221	Torsin A	HUMAN|HGNC=3098|UniProtKB=O14656	Torsin-1A	ISS	12421356	PubMed	PTHR10760:SF15	TORSIN-1A
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	RAT|RGD=2246|UniProtKB=Q07652	Voltage-dependent R-type calcium channel subunit alpha-1E	IDA	14624853	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00018	EGF receptor signaling pathway	P00561	STAT	CANLF|Ensembl=ENSCAFG00000015346|UniProtKB=E2RE22	Signal transducer and activator of transcription	ISS	14662325	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00005	Angiogenesis	P00252	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	9763606	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00047	PDGF signaling pathway	P01152	RasGAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	ISS	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00057	Wnt signaling pathway	P01428	Frizzled	BOVIN|Ensembl=ENSBTAG00000020590|UniProtKB=G3N2W8	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF34	FRIZZLED-2
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	ORNAN|Ensembl=ENSOANG00000008874|UniProtKB=F7F2K2	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF23	FRIZZLED-4
P00034	Integrin signalling pathway	P00920	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	IPI	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MOUSE|MGI=MGI=87938|UniProtKB=P18762	Beta-2 adrenergic receptor	IDA	7669252	PubMed	PTHR24248:SF21	BETA-2 ADRENERGIC RECEPTOR
P04393	Ras Pathway	P04570	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00542	EGFR	DROME|FlyBase=FBgn0003731|UniProtKB=P04412	Epidermal growth factor receptor	IGI	6175066	gi	PTHR24416:SF95	EPIDERMAL GROWTH FACTOR RECEPTOR
P06959	CCKR signaling map	P07086	PLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	RCA	8760101	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04398	p53 pathway feedback loops 2	G04714	PTEN	DICDI|dictyBase=DDB_G0286557|UniProtKB=Q8T9S7	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI			PTHR12305:SF79	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00046	Oxidative stress response	P01121	MKK3/6	CANLF|Ensembl=ENSCAFG00000018530|UniProtKB=F1PXD3	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00052	TGF-beta signaling pathway	P01284	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00805	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	BOVIN|Ensembl=ENSBTAG00000018777|UniProtKB=E1BHU9	Uncharacterized protein	ISS	94139935	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00060	Ubiquitin proteasome pathway	P01491	E2	MACMU|Ensembl=ENSMMUG00000020634|UniProtKB=F6VYS3	Uncharacterized protein	ISS			PTHR43902:SF2	UBIQUITIN-CONJUGATING ENZYME E2 N
P00010	B cell activation	P00402	Jnk	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00057	Wnt signaling pathway	P01465	Ggamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05731	GABA-B receptor II signaling	P05752	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	RCA	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00899	IRS 1-4	MOUSE|MGI=MGI=1338009|UniProtKB=Q9Z0Y7	Insulin receptor substrate 4	ISS	5031805	gi	PTHR10614:SF2	INSULIN RECEPTOR SUBSTRATE 4
P05918	p38 MAPK pathway	P06031	p38alpha	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00586	Gq	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00005	Angiogenesis	P00200	Dsh	MONDO|Ensembl=ENSMODG00000003229|UniProtKB=F6TYA8	Uncharacterized protein (Fragment)	ISS	11212302	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00034	Integrin signalling pathway	P00927	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00005	Angiogenesis	P00223	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	MOUSE|MGI=MGI=94925|UniProtKB=P30728	D(3) dopamine receptor	ISS	11861492	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00053	T cell activation	P01318	PKC-theta	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IGI	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00045	Notch signaling pathway	P01103	Next	RAT|RGD=620761|UniProtKB=Q9R172	Neurogenic locus notch homolog protein 3	ISS	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00030	Hypoxia response via HIF activation	P00823	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	10799299	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	RAT|RGD=2246|UniProtKB=Q07652	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	11976940	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00049	Parkinson disease	P01236	Casein kinase II	DANRE|ZFIN=ZDB-GENE-990415-28|UniProtKB=Q7ZU33	Ck2a2 protein	IDA	10617630	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00034	Integrin signalling pathway	P00951	Jnk	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00017	DNA replication	P00527	Histones	CRYNJ|EnsemblGenome=CNB00570|UniProtKB=Q5KMT3	Histone H3	ISS	12413958	PubMed	PTHR11426:SF47	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01001	KA4	MONDO|Ensembl=ENSMODG00000013079|UniProtKB=F7FB74	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00310	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00916	Ras	DICPU|Gene=DICPUDRAFT_47179|UniProtKB=F0ZI47	Putative uncharacterized protein rasB	ISS	7997267	PubMed	PTHR24070:SF206	RAS-LIKE PROTEIN RASB
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04580	TRH Receptor	BOVIN|Ensembl=ENSBTAG00000019997|UniProtKB=O46639	Thyrotropin-releasing hormone receptor	ISS	7509436	PubMed	PTHR24243:SF115	THYROTROPIN-RELEASING HORMONE RECEPTOR
P02747	Histidine biosynthesis	P02991	Histidinephosphate aminotransferase	PSEAE|EnsemblGenome=PA4447|UniProtKB=Q9HVX0	Histidinol-phosphate aminotransferase 1	ISS			PTHR42885:SF2	HISTIDINOL-PHOSPHATE AMINOTRANSFERASE
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00023	General transcription regulation	P00664	TFIIH complex	YEAST|SGD=S000006260|UniProtKB=Q12004	RNA polymerase II transcription factor B subunit 4	ISS			PTHR12831:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3
P04393	Ras Pathway	P04570	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00566	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00554	Shc	HUMAN|HGNC=29869|UniProtKB=P98077	SHC-transforming protein 2	ISS	600560	OMIM	PTHR10337:SF5	SHC-TRANSFORMING PROTEIN 2
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	10218114	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00018	EGF receptor signaling pathway	P00558	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	IGI	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00046	Oxidative stress response	P01137	MNK1/2	MACMU|Ensembl=ENSMMUG00000020162|UniProtKB=F6TJV6	Uncharacterized protein	ISS	9155018	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00010	B cell activation	P00400	Btk	PANTR|Ensembl=ENSPTRG00000022104|UniProtKB=H2QYW8	Tyrosine-protein kinase	ISS	10521450	PubMed	PTHR24418:SF92	TYROSINE-PROTEIN KINASE BTK
P06587	Nicotine pharmacodynamics pathway	P06592	CHRNA6	MACMU|Ensembl=ENSMMUG00000000163|UniProtKB=F7HLV0	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF82	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-6
P00010	B cell activation	P00383	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IDA	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	TAS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00041	Metabotropic glutamate receptor group I pathway	P01062	mGluR1	MACMU|Ensembl=ENSMMUG00000016428|UniProtKB=F7GU00	Metabotropic glutamate receptor 1 isoform alpha	ISS	14614461	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00034	Integrin signalling pathway	P00907	ERK	MACMU|Ensembl=ENSMMUG00000008503|UniProtKB=F6TGJ6	Uncharacterized protein	ISS	8444355	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00010	B cell activation	P00402	Jnk	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00005	Angiogenesis	P00251	cPLA2	BOVIN|Ensembl=ENSBTAG00000013298|UniProtKB=A4IFJ5	Cytosolic phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1712|UniProtKB=Q6PBY0	Guanine nucleotide binding protein (G protein), beta 5	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00047	PDGF signaling pathway	P01146	Ikk	RAT|RGD=621375|UniProtKB=Q9QY78	Inhibitor of nuclear factor kappa-B kinase subunit beta	RCA			PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	RAT|RGD=2732|UniProtKB=P22756	Glutamate receptor ionotropic, kainate 1	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00018	EGF receptor signaling pathway	P00557	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	IDA	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00034	Integrin signalling pathway	P00951	Jnk	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00029	Huntington disease	P00796	Kainate receptor	CHICK|Ensembl=ENSGALG00000001172|UniProtKB=P19439	Probable glutamate receptor	IDA	12871085	PubMed	PTHR18966:SF282	GLUTAMATE RECEPTOR-RELATED
P00059	p53 pathway	P01485	p53	HUMAN|HGNC=15979|UniProtKB=Q9H3D4	Tumor protein 63	TAS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MONDO|Ensembl=ENSMODG00000001430|UniProtKB=F7BCI5	Uncharacterized protein	ISS	12890691	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	ANOGA|EnsemblGenome=AGAP004613|UniProtKB=Q7Q7P1	AGAP004613-PA (Fragment)	ISS	9700720	PubMed	PTHR43893:SF6	DOPAMINE RECEPTOR 1
P00053	T cell activation	P01324	rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	10802295	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P05918	p38 MAPK pathway	P06031	p38alpha	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	RCA	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00048	PI3 kinase pathway	P01176	JAK	MOUSE|MGI=MGI=96629|UniProtKB=Q62120	Tyrosine-protein kinase JAK2	IDA	12686512	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	TAS	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00047	PDGF signaling pathway	P01159	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MACMU|Ensembl=ENSMMUG00000005688|UniProtKB=F6U5C5	Transcription factor jun-B	ISS	10664585	PubMed	PTHR11462:SF37	TRANSCRIPTION FACTOR JUN-B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05913	Enkephalin release	P05972	PKA	DICDI|dictyBase=DDB_G0283907|UniProtKB=P34099	cAMP-dependent protein kinase catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PANTR|Ensembl=ENSPTRG00000017674|UniProtKB=H2Q189	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	12657601	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00029	Huntington disease	P00779	TBP	CHICK|Gene=TBP|UniProtKB=O13270	TATA-box-binding protein	IPI	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00709	Glycogen synthase D	HUMAN|HGNC=4706|UniProtKB=P13807	Glycogen [starch] synthase, muscle	IDA	4212312	PubMed	PTHR10176:SF2	GLYCOGEN  STARCH  SYNTHASE, MUSCLE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P02726	Aminobutyrate degradation	P02824	Succinate semi-aldehyde dehydrogenase	NEUCR|EnsemblGenome=EFNCRG00000004180|UniProtKB=Q7S8W6	Betaine aldehyde dehydrogenase 2	ISS			PTHR11699:SF65	ALDEHYDE DEHYDROGENASE
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MOUSE|MGI=MGI=3710243|UniProtKB=A2AQP0	Myosin-7B	ISS	10938134	PubMed	PTHR13140:SF358	MYOSIN-7B
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	BOVIN|Ensembl=ENSBTAG00000001067|UniProtKB=E1BAB4	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Gene=PLCD4|UniProtKB=P21671	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	7822322	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	RCA	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00005	Angiogenesis	P00223	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01236	Casein kinase II	TAKRU|Ensembl=ENSTRUG00000000811|UniProtKB=H2RP90	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00034	Integrin signalling pathway	P00941	Integrin alpha	MACMU|Ensembl=ENSMMUG00000021927|UniProtKB=F6T4B4	Uncharacterized protein	ISS	3487386	PubMed	PTHR23220:SF69	INTEGRIN ALPHA-9
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	HUMAN|HGNC=3978|UniProtKB=O75891	Cytosolic 10-formyltetrahydrofolate dehydrogenase	IC			PTHR11699:SF120	CYTOSOLIC 10-FORMYLTETRAHYDROFOLATE DEHYDROGENASE
P02775	Salvage pyrimidine ribonucleotides	P03155	Cytosine deaminase	STRCO|Gene=CAC32309|UniProtKB=Q9AK79	tRNA-specific adenosine deaminase	ISS			PTHR11079:SF149	TRNA-SPECIFIC ADENOSINE DEAMINASE
P00056	VEGF signaling pathway	P01419	Ets	MOUSE|MGI=MGI=95455|UniProtKB=P27577	Protein C-ets-1	ISS	9157999	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00799	JNK-2	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00057	Wnt signaling pathway	P01451	Galpha	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IDA	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CANLF|Gene=MYH9|UniProtKB=Q258K2	Myosin-9	ISS	89264452	PubMed	PTHR13140:SF317	MYOSIN-9
P00047	PDGF signaling pathway	P01142	p90RSK	BOVIN|Ensembl=ENSBTAG00000039153|UniProtKB=F1MQE1	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF41	RIBOSOMAL PROTEIN S6 KINASE ALPHA-4
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00034	Integrin signalling pathway	P00920	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00021	FGF signaling pathway	P00629	PP2A	XENTR|Xenbase=XB-GENE-957248|UniProtKB=Q6GLE6	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00974	Receptor subunit beta	MACMU|Ensembl=ENSMMUG00000003959|UniProtKB=F6ZFB3	Uncharacterized protein	ISS			PTHR20859:SF50	INTERLEUKIN-10 RECEPTOR SUBUNIT BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00303	c-Jun	CHICK|Gene=JUN|UniProtKB=P18870	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00019	Endothelin signaling pathway	P00572	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05913	Enkephalin release	G06045	preproenkephalin	RAT|RGD=68946|UniProtKB=P04094	Proenkephalin-A	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	ORYSJ|EnsemblGenome=OS01G0296100|UniProtKB=Q94IZ2	Os01g0296100 protein	TAS			PTHR24057:SF34	SUBFAMILY NOT NAMED
P05917	Opioid proopiomelanocortin pathway	P06010	proopiomelanocortin	HUMAN|HGNC=9201|UniProtKB=P01189	Pro-opiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P02738	De novo purine biosynthesis	P02907	dADP kinase	ORYSJ|EnsemblGenome=OS10G0563700|UniProtKB=Q7XC37	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00059	p53 pathway	P04633	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00236	PI3K	DROME|FlyBase=FBgn0015278|UniProtKB=Q7K3H0	LD28067p	ISS			PTHR10048:SF64	LD28067P
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00828	Galphai	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	RCA			PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00046	Oxidative stress response	P01131	MKP5	PANTR|Ensembl=ENSPTRG00000017534|UniProtKB=H2QS06	Dual specificity protein phosphatase	ISS			PTHR10159:SF309	DUAL SPECIFICITY PROTEIN PHOSPHATASE 1
P00029	Huntington disease	P00774	Dynein complex	CANLF|Ensembl=ENSCAFG00000017986|UniProtKB=F1PGY9	Uncharacterized protein	ISS	9454836	PubMed	PTHR10676:SF314	CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1
P04393	Ras Pathway	P04564	MAPKAP	HUMAN|HGNC=6888|UniProtKB=Q16644	MAP kinase-activated protein kinase 3	IDA	11157753	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01435	SWI/SNF	MOUSE|MGI=MGI=1915392|UniProtKB=Q6ZPV2	DNA helicase INO80	ISS	11532957	PubMed	PTHR10799:SF868	DNA HELICASE INO80
P00059	p53 pathway	P04611	P300	MOUSE|MGI=MGI=1276116|UniProtKB=B2RWS6	Histone acetyltransferase p300	ISS	8413673	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00041	Metabotropic glutamate receptor group I pathway	P01062	mGluR1	HUMAN|HGNC=4593|UniProtKB=Q13255	Metabotropic glutamate receptor 1	ISS	14614461	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00056	VEGF signaling pathway	P01408	Akt/PKB	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CANLF|Ensembl=ENSCAFG00000028654|UniProtKB=J9P702	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00005	Angiogenesis	P00221	JNK1	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	ISS	97102676	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	ANOGA|EnsemblGenome=AGAP002156|UniProtKB=Q7QK53	AGAP002156-PA	IDA	12629106	PubMed	PTHR24241:SF59	ADIPOKINETIC HORMONE RECEPTOR, ISOFORM C
P00054	Toll receptor signaling pathway	P01368	MKK2	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00807	Actin	BOVIN|Gene=ACTG2|UniProtKB=Q5E9B5	Actin, gamma-enteric smooth muscle	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	XENTR|Xenbase=XB-GENE-488460|UniProtKB=Q6DIY4	TATA box-binding protein-like protein 1	ISS	600075	OMIM	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00059	p53 pathway	P04630	PP2A	HUMAN|HGNC=9299|UniProtKB=P67775	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01451	Galpha	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00624	14-3-3	CAEEL|WormBase=WBGene00003920|UniProtKB=P41932	14-3-3-like protein 1	IGI	21643941	PubMed	PTHR18860:SF21	14-3-3-LIKE PROTEIN 1
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	CANLF|Gene=DRD2|UniProtKB=Q9GJU1	D(2) dopamine receptor	ISS	11861492	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00025	Hedgehog signaling pathway	P00692	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00012	Cadherin signaling pathway	P00477	GSK3beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008422|UniProtKB=F6VUT7	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	BOVIN|Ensembl=ENSBTAG00000011757|UniProtKB=Q9XT97	Presenilin-1	TAS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MACMU|Ensembl=ENSMMUG00000000223|UniProtKB=F6XHK8	Uncharacterized protein	ISS	12441358	PubMed	PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P00004	Alzheimer disease-presenilin pathway	P00127	APP	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00048	PI3 kinase pathway	P01177	P110ACT	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DANRE|ZFIN=ZDB-GENE-030131-55|UniProtKB=Q6XNL8	Actin	IDA	11889139	PubMed	PTHR11937:SF263	ACTIN
P00021	FGF signaling pathway	P00640	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00059	p53 pathway	P04620	TRAF	CANLF|Ensembl=ENSCAFG00000019541|UniProtKB=J9NS71	Uncharacterized protein	ISS	8069916	PubMed	PTHR10131:SF21	TNF RECEPTOR-ASSOCIATED FACTOR 2
P05731	GABA-B receptor II signaling	P05753	Ca channel	MOUSE|MGI=MGI=109482|UniProtKB=P97445	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	8386525	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04393	Ras Pathway	P04542	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01465	Ggamma	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	XENTR|Xenbase=XB-GENE-490883|UniProtKB=Q6NVA9	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00577	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	IGI	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00057	Wnt signaling pathway	P01440	Cadherin	MONDO|Ensembl=ENSMODG00000003670|UniProtKB=F7ABP2	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF106	CADHERIN-18
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06860	Rac1	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	RCA	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	RAT|RGD=2027|UniProtKB=P63269	Actin, gamma-enteric smooth muscle	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P05730	Endogenous cannabinoid signaling	P05746	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	PANTR|Ensembl=ENSPTRG00000006175|UniProtKB=H2R2N7	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF721	MYOSIN-6
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	HUMAN|HGNC=1964|UniProtKB=P30926	Neuronal acetylcholine receptor subunit beta-4	IC	22213672	PubMed	PTHR18945:SF385	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-4
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000014807|UniProtKB=F6W548	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	RAT|RGD=2746|UniProtKB=P31424	Metabotropic glutamate receptor 5	ISS	9407094	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	RAT|RGD=70487|UniProtKB=Q9WU82	Catenin beta-1	IDA	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CAEBR|Gene=CBG05896|UniProtKB=A8X1E0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF147	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-2
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04374	5HT2 type receptor mediated signaling pathway	P04413	K+ channel	BOVIN|Ensembl=ENSBTAG00000018193|UniProtKB=E1BHX8	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	RCA	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04633	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02738	De novo purine biosynthesis	P02889	dGDP kinase	SULSO|EnsemblGenome=SSO0230|UniProtKB=Q980Q7	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00053	T cell activation	P01332	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	IDA	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00029	Huntington disease	P00807	Actin	TRIAD|EnsemblGenome=TriadG49626|UniProtKB=B3RKR4	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	P01431	LRP5/6	ORNAN|Ensembl=ENSOANG00000006877|UniProtKB=F7CQF2	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P04374	5HT2 type receptor mediated signaling pathway	P04413	K+ channel	RAT|RGD=61997|UniProtKB=O54912	Potassium channel subfamily K member 3	ISS	11875121	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00005	Angiogenesis	P00221	JNK1	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02743	Formyltetrahydroformate biosynthesis	P02956	Formyl tetrahydrofolate deformylase	HALSA|EnsemblGenome=VNG_1946G|UniProtKB=Q9HNU0	Formyltetrahydrofolate deformylase	ISS			PTHR42706:SF1	FORMYLTETRAHYDROFOLATE DEFORMYLASE 1, MITOCHONDRIAL-RELATED
P00021	FGF signaling pathway	P00640	PI3K	CAEEL|WormBase=WBGene00006932|UniProtKB=Q9TXI7	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	ANOGA|EnsemblGenome=AGAP005912|UniProtKB=Q7Q6D3	AGAP005912-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02770	Pyridoxal phosphate salvage pathway	P03123	Pyridoxine-5-phosphate oxidase	STRCO|EnsemblGenome=CAB95898|UniProtKB=Q9K3V7	Pyridoxine/pyridoxamine 5'-phosphate oxidase	ISS	12000953	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=109246|UniProtKB=P97288	5-hydroxytryptamine receptor 4	IDA			PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P02761	Pantothenate biosynthesis	P03066	Aspartate decarboxylase	BACTN|EnsemblGenome=BT_4309|UniProtKB=Q89ZR7	Aspartate 1-decarboxylase	ISS			PTHR21012:SF0	ASPARTATE 1-DECARBOXYLASE
P00048	PI3 kinase pathway	P01177	P110ACT	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	HUMAN|HGNC=10485|UniProtKB=Q15413	Ryanodine receptor 3	ISS	15858232	PubMed	PTHR13715:SF16	RYANODINE RECEPTOR 3
P04393	Ras Pathway	P04541	p90RSK	CHICK|Ensembl=ENSGALG00000016406|UniProtKB=F1NLJ3	Uncharacterized protein	ISS	6755374	gi	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	BOVIN|Ensembl=ENSBTAG00000015670|UniProtKB=E1B7J7	Uncharacterized protein	ISS	11259591	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00005	Angiogenesis	P00242	TCF	MOUSE|MGI=MGI=1202879|UniProtKB=Q924A0	Transcription factor 7-like 2	ISS	12356903	PubMed	PTHR10373:SF32	TRANSCRIPTION FACTOR 7-LIKE 2
P00053	T cell activation	P01336	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	TRYB2|Gene=Tb11.01.7800|UniProtKB=Q381H3	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P06959	CCKR signaling map	P07041	SP3	HUMAN|HGNC=11208|UniProtKB=Q02447	Transcription factor Sp3	RCA	17463184	PubMed	PTHR23235:SF3	TRANSCRIPTION FACTOR SP3
P00020	FAS signaling pathway	P00608	Pro-Caspase3	CHICK|Ensembl=ENSGALG00000010638|UniProtKB=O93417	Caspase-3	IGI	11675509	PubMed	PTHR10454:SF198	CASPASE-3
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	BOVIN|Ensembl=ENSBTAG00000025274|UniProtKB=Q3MHM5	Tubulin beta-4B chain	ISS	9454836	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00034	Integrin signalling pathway	P00951	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	CANLF|Ensembl=ENSCAFG00000024151|UniProtKB=E2R795	Tyrosine-protein kinase receptor	ISS	12644000	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00018	EGF receptor signaling pathway	P00560	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00925	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05913	Enkephalin release	P05972	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	176910	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04393	Ras Pathway	P04567	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IDA	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	ANOGA|EnsemblGenome=AGAP004142|UniProtKB=Q7QB79	Aspartate aminotransferase	ISS			PTHR11879:SF22	ASPARTATE AMINOTRANSFERASE
P00029	Huntington disease	P00774	Dynein complex	BOVIN|Ensembl=ENSBTAG00000016784|UniProtKB=F1N5R7	Uncharacterized protein	ISS	9454836	PubMed	PTHR10676:SF310	DYNEIN HEAVY CHAIN 7, AXONEMAL
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00034	Integrin signalling pathway	P00932	FAK	MONDO|Ensembl=ENSMODG00000015932|UniProtKB=F6Z395	Uncharacterized protein	ISS	12640026	PubMed	PTHR24418:SF94	PROTEIN-TYROSINE KINASE 2-BETA
P02740	De novo pyrimidine ribonucleotides biosythesis	P02926	Aspartate carbamoyltransferase	LEIMA|EnsemblGenome=LmjF.16.0540|UniProtKB=Q4QEW6	Putative aspartate carbamoyltransferase	ISS			PTHR11405:SF16	ASPARTATE CARBAMOYLTRANSFERASE, CHLOROPLASTIC
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	DROME|FlyBase=FBgn0260798|UniProtKB=P32865	G protein-coupled receptor kinase 1	RCA			PTHR24355:SF18	PROTEIN-SERINE/THREONINE KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00006	Apoptosis signaling pathway	P00269	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	2574500	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00029	Huntington disease	P00788	Calpain	HUMAN|HGNC=1477|UniProtKB=Q9HC96	Calpain-10	IDA	11675509	PubMed	PTHR10183:SF30	CALPAIN-10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	HUMAN|HGNC=9855|UniProtKB=P62834	Ras-related protein Rap-1A	IDA	8576107	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00020	FAS signaling pathway	P00615	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	P01438	PP2A	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00922	Collagen	MACMU|Ensembl=ENSMMUG00000002595|UniProtKB=F7HQD8	Uncharacterized protein	ISS	10778855	PubMed	PTHR44557:SF1	COLLAGEN ALPHA-1 XIV  CHAIN
P00018	EGF receptor signaling pathway	P00541	Spry	PANTR|Ensembl=ENSPTRG00000017360|UniProtKB=H2QRP3	Uncharacterized protein	ISS	22024232	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P00035	Interferon-gamma signaling pathway	P00953	Jak1	BOVIN|Ensembl=ENSBTAG00000003147|UniProtKB=F1N0D6	Tyrosine-protein kinase	ISS	11929133	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00022	General transcription by RNA polymerase I	P00657	TBP	HUMAN|HGNC=11589|UniProtKB=P62380	TATA box-binding protein-like protein 1	ISS	10082669	PubMed	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00010	B cell activation	P00383	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00053	T cell activation	P01332	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00008	Axon guidance mediated by Slit/Robo	P00348	Robo	MONDO|Ensembl=ENSMODG00000016857|UniProtKB=F6QGK3	Uncharacterized protein	ISS			PTHR44096:SF1	ROUNDABOUT HOMOLOG 1
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	PANTR|Ensembl=ENSPTRG00000008851|UniProtKB=H2QCE4	Serine hydroxymethyltransferase	ISS			PTHR11680:SF21	SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01457	GBeta	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	IDA	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	HUMAN|HGNC=7776|UniProtKB=Q13469	Nuclear factor of activated T-cells, cytoplasmic 2	ISS	12015605	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P06664	Gonadotropin-releasing hormone receptor pathway	P06850	PKCs(3)	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	RCA	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	NAS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P02753	Methionine biosynthesis	P03024	Homocysteine transmethylase	PANTR|Ensembl=ENSPTRG00000002145|UniProtKB=H2R7Z7	5-methyltetrahydrofolate-homocysteine methyltransferase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	PANTR|Ensembl=ENSPTRG00000016293|UniProtKB=H2QPW8	Serine/threonine-protein kinase receptor	ISS	10683140	PubMed	PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P00034	Integrin signalling pathway	P00907	ERK	BOVIN|Ensembl=ENSBTAG00000005865|UniProtKB=G5E577	Uncharacterized protein	ISS	8444355	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	RCA	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00807	Actin	CHICK|Gene=ACTR2|UniProtKB=P53488	Actin-related protein 2	ISS	10974003	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00115	Nicastrin	ARATH|TAIR=AT3G52640|UniProtKB=Q8GUM5	Nicastrin	IDA	16096062	PubMed	PTHR21092:SF0	NICASTRIN
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	ANOGA|EnsemblGenome=AGAP002176|UniProtKB=Q7QK68	AGAP002176-PA	IDA			PTHR42884:SF13	NEUROENDOCRINE CONVERTASE 2
P02751	Lysine biosynthesis	P03009	Aspartokinase	NEUCR|EnsemblGenome=EFNCRG00000003951|UniProtKB=Q1K7N1	Aspartokinase	ISS			PTHR21499:SF3	ASPARTOKINASE
P02741	Flavin biosynthesis	P02936	FAD synthetase	MACMU|Ensembl=ENSMMUG00000014829|UniProtKB=F6VQM7	Uncharacterized protein	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00025	Hedgehog signaling pathway	P00682	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00846	JAK	HUMAN|HGNC=6192|UniProtKB=O60674	Tyrosine-protein kinase JAK2	ISS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Ensembl=ENSPTRG00000013825|UniProtKB=H2RAK4	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	RCA	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00049	Parkinson disease	P01211	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05913	Enkephalin release	P05975	GPCR (s)	RAT|RGD=3234|UniProtKB=P33535	Mu-type opioid receptor	ISS	12093103	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IPI	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT1G07880|UniProtKB=Q9LQQ9	Mitogen-activated protein kinase 13	ISS	10851062	PubMed	PTHR24055:SF185	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	IC	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	CANAL|CGD=CAL0068551|UniProtKB=Q5AAR9	Phosphatidylinositol 3-kinase	IGI	20330542	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00010	B cell activation	P00368	vav	CANLF|Ensembl=ENSCAFG00000018590|UniProtKB=E2RGT8	Uncharacterized protein	ISS	10661401	PubMed	PTHR22826:SF112	PROTO-ONCOGENE VAV
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01084	CHT1	CAEBR|Gene=CBG01811|UniProtKB=A8WQR8	Protein CBR-CHO-1	RCA			PTHR11819:SF12	HIGH-AFFINITY CHOLINE TRANSPORTER 1
P00021	FGF signaling pathway	P00644	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00056	VEGF signaling pathway	P01414	PLC-gamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00049	Parkinson disease	P01219	SAPK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	NAS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00029	Huntington disease	P00805	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04661	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00056	VEGF signaling pathway	P01403	VEGFR-2	HUMAN|HGNC=6307|UniProtKB=P35968	Vascular endothelial growth factor receptor 2	IDA	11824379	PubMed	PTHR24416:SF45	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2
P00019	Endothelin signaling pathway	P00586	Gq	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00047	PDGF signaling pathway	P01173	STAT	HUMAN|HGNC=11368|UniProtKB=P42226	Signal transducer and activator of transcription 6	ISS	8085155	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	TAS	7492337	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	MACMU|Gene=HTR2A|UniProtKB=P50128	5-hydroxytryptamine receptor 2A	ISS	8143856	PubMed	PTHR24247:SF30	5-HYDROXYTRYPTAMINE RECEPTOR 2A
P00005	Angiogenesis	P00238	Ras	BOVIN|Ensembl=ENSBTAG00000009778|UniProtKB=E1BMX0	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	IDA	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00059	p53 pathway	P01480	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00050	Plasminogen activating cascade	P01256	uPAR	MOUSE|MGI=MGI=97612|UniProtKB=P35456	Urokinase plasminogen activator surface receptor	ISS	7242179	gi	PTHR10624:SF6	UROKINASE PLASMINOGEN ACTIVATOR SURFACE RECEPTOR
P00057	Wnt signaling pathway	P01435	SWI/SNF	MOUSE|MGI=MGI=1915344|UniProtKB=Q6PDG5	SWI/SNF complex subunit SMARCC2	ISS	11532957	PubMed	PTHR12802:SF38	SWI/SNF COMPLEX SUBUNIT SMARCC2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	9516481	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	ANOGA|EnsemblGenome=AGAP004613|UniProtKB=Q7Q7P1	AGAP004613-PA (Fragment)	ISS	11861492	PubMed	PTHR43893:SF6	DOPAMINE RECEPTOR 1
P00045	Notch signaling pathway	P01103	Next	CANLF|Ensembl=ENSCAFG00000010476|UniProtKB=F1PS94	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00053	T cell activation	P01305	Calmodulin	MONDO|Ensembl=ENSMODG00000023174|UniProtKB=F7D7P2	Uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF197	CALMODULIN-LIKE PROTEIN 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ORYSJ|EnsemblGenome=OS12G0163700|UniProtKB=Q0IPW3	Os12g0163700 protein	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05913	Enkephalin release	P05974	G-Protein (i)	ANOGA|EnsemblGenome=AGAP005773|UniProtKB=A0NEH6	AGAP005773-PA	IC	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	3045562	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	PANTR|Ensembl=ENSPTRG00000020589|UniProtKB=H2QWQ6	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=30035|UniProtKB=Q8WYR1	Phosphoinositide 3-kinase regulatory subunit 5	ISS	12507995	PubMed	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00034	Integrin signalling pathway	P00918	Caveolin	PANTR|Ensembl=ENSPTRG00000019613|UniProtKB=Q2QLF2	Caveolin-1	ISS	9741627	PubMed	PTHR10844:SF18	CAVEOLIN-1
P00057	Wnt signaling pathway	P01443	Phospholipase C	ANOGA|Gene=AgaP_AGAP009115|UniProtKB=Q7PW25	Phosphoinositide phospholipase C (Fragment)	ISS	10934033	PubMed	PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00010	B cell activation	P00372	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	TAS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00036	Interleukin signaling pathway	P00975	RasGAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	ISS	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	10693759	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00046	Oxidative stress response	P01129	JNK1/2	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00045	Notch signaling pathway	P01118	Numb	PANTR|Ensembl=ENSPTRG00000006513|UniProtKB=H2R3J4	Uncharacterized protein	ISS	10468633	PubMed	PTHR11232:SF33	PROTEIN NUMB HOMOLOG
P00029	Huntington disease	P00774	Dynein complex	CANLF|Ensembl=ENSCAFG00000020409|UniProtKB=F1P6V8	Uncharacterized protein	ISS	9454836	PubMed	PTHR12688:SF1	CYTOPLASMIC DYNEIN 1 LIGHT INTERMEDIATE CHAIN 2
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04384	Gamma-aminobutyric acid synthesis	P04482	Glutamate decarboxylase	CHICK|Ensembl=ENSGALG00000009589|UniProtKB=Q9YI58	Glutamate decarboxylase 1	ISS	2247446	PubMed	PTHR11999:SF57	GLUTAMATE DECARBOXYLASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00717	Phosphorylase b	MACMU|Ensembl=ENSMMUG00000022604|UniProtKB=F6Z728	Alpha-1,4 glucan phosphorylase	ISS	4318782	PubMed	PTHR11468:SF13	GLYCOGEN PHOSPHORYLASE, MUSCLE FORM
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00788	Calpain	HUMAN|HGNC=13249|UniProtKB=Q6ZSI9	Calpain-12	IDA	11675509	PubMed	PTHR10183:SF280	CALPAIN-12
P02738	De novo purine biosynthesis	P02894	IMP cyclohydrolase	CAEEL|WormBase=WBGene00016957|UniProtKB=Q95QQ4	5-Aminoimidazole-4-carboxamide ribonucleotide formylTransferase/IMP Cyclohydrolase homolog	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P00034	Integrin signalling pathway	P00931	Integrin beta	BOVIN|Ensembl=ENSBTAG00000009987|UniProtKB=F1MTN1	Integrin beta	ISS	124968	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	CHICK|Gene=ADCY9|UniProtKB=Q9DGG6	Adenylate cyclase type 9	IGI	2491850	PubMed	PTHR11920:SF319	ADENYLATE CYCLASE TYPE 9
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00539	14-3-3	CANLF|Ensembl=ENSCAFG00000007716|UniProtKB=E2QZT7	Uncharacterized protein	ISS	93387487	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DROME|FlyBase=FBgn0003093|UniProtKB=P13678	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P02775	Salvage pyrimidine ribonucleotides	P03149	Cytidine kinase	DROME|FlyBase=FBgn0022029|UniProtKB=Q8MQK4	Uridine kinase	ISS			PTHR10285:SF123	URIDINE KINASE
P04393	Ras Pathway	P04572	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04398	p53 pathway feedback loops 2	P04657	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00223	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1718748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00560	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00467	alpha-catenin	MONDO|Ensembl=ENSMODG00000012050|UniProtKB=F7ALE8	Uncharacterized protein	ISS	9362521	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P02781	Threonine biosynthesis	P03189	Aspartate kinase	ARATH|TAIR=AT5G13280|UniProtKB=Q9LYU8	Aspartokinase 1, chloroplastic	ISS			PTHR21499:SF38	ASPARTOKINASE 1, CHLOROPLASTIC
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00018	EGF receptor signaling pathway	P00539	14-3-3	HUMAN|HGNC=12853|UniProtKB=Q04917	14-3-3 protein eta	ISS	10407019	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P04393	Ras Pathway	P04570	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00054	Toll receptor signaling pathway	P01375	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CHICK|Ensembl=ENSGALG00000009640|UniProtKB=F1P0I0	Muscarinic acetylcholine receptor	IDA			PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P06959	CCKR signaling map	P07088	RYR1/2/3	HUMAN|HGNC=10485|UniProtKB=Q15413	Ryanodine receptor 3	RCA	2008014	PubMed	PTHR13715:SF16	RYANODINE RECEPTOR 3
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	BOVIN|Gene=DRD2|UniProtKB=P20288	D(2) dopamine receptor	ISS	2039532	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=88354|UniProtKB=P09803	Cadherin-1	IDA	8120095	PubMed	PTHR24027:SF319	CADHERIN-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CHICK|Ensembl=ENSGALG00000011086|UniProtKB=P68139	Actin, alpha skeletal muscle	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P04384	Gamma-aminobutyric acid synthesis	P04482	Glutamate decarboxylase	ANOGA|EnsemblGenome=AGAP005866|UniProtKB=Q7PNL7	AGAP005866-PA	ISS	2247446	PubMed	PTHR11999:SF137	GLUTAMATE DECARBOXYLASE
P00029	Huntington disease	P00780	Microtubule	HUMAN|HGNC=20776|UniProtKB=Q9BUF5	Tubulin beta-6 chain	IDA	12932731	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00048	PI3 kinase pathway	P01192	p110	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00029	Huntington disease	P00790	beta-Tubulin	ARATH|TAIR=AT5G44340|UniProtKB=P24636	Tubulin beta-4 chain	TAS	12932731	PubMed	PTHR11588:SF245	TUBULIN BETA-4 CHAIN-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Ensembl=ENSCAFG00000014602|UniProtKB=F1PAI8	Uncharacterized protein	ISS	11781138	PubMed	PTHR24248:SF25	ALPHA-2C ADRENERGIC RECEPTOR
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00021	FGF signaling pathway	P00630	RKIP	ORYSJ|EnsemblGenome=OS11G0152500|UniProtKB=Q53Q71	CEN-like protein 2, putative, expressed	ISS			PTHR11362:SF13	PROTEIN TERMINAL FLOWER 1
P00029	Huntington disease	P00775	Rac	MONDO|Ensembl=ENSMODG00000024005|UniProtKB=F7A4B3	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF158	RHO-RELATED GTP-BINDING PROTEIN RHOG
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000003762|UniProtKB=A5PJS1	GNB5 protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P06959	CCKR signaling map	G07281	PAI1	HUMAN|HGNC=8583|UniProtKB=P05121	Plasminogen activator inhibitor 1	RCA	21193525	PubMed	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00020	FAS signaling pathway	P00615	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00774	Dynein complex	RAT|RGD=71072|UniProtKB=Q9QXU8	Cytoplasmic dynein 1 light intermediate chain 1	IPI	9454836	PubMed	PTHR12688:SF2	CYTOPLASMIC DYNEIN 1 LIGHT INTERMEDIATE CHAIN 1
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00046	Oxidative stress response	P01132	c-jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00046	Oxidative stress response	P01125	Stat1	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	14984365	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00005	Angiogenesis	P00256	PLC-gamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01448	CBP	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P02779	Thiamin biosynthesis	P03175	1-Deoxyxylulose-5-phosphate synthase	THEMA|EnsemblGenome=TM_1770|UniProtKB=Q9X291	1-deoxy-D-xylulose-5-phosphate synthase	ISS			PTHR43322:SF5	1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE 1-RELATED
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	PANTR|Ensembl=ENSPTRG00000024326|UniProtKB=H2R231	Uncharacterized protein	ISS	12697749	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00047	PDGF signaling pathway	P01142	p90RSK	PANTR|Ensembl=ENSPTRG00000000387|UniProtKB=H2PYE3	Ribosomal protein S6 kinase	ISS	7688567	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IGI	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00019	Endothelin signaling pathway	P00580	ET-RA/B	MOUSE|MGI=MGI=102720|UniProtKB=P48302	Endothelin B receptor	IGI	12812796	PubMed	PTHR24243:SF30	ENDOTHELIN B RECEPTOR
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P02734	Chorismate biosynthesis	P02872	3-Dehydroquinate synthase	THEMA|EnsemblGenome=TM_0348|UniProtKB=Q9WYI3	Bifunctional shikimate kinase/3-dehydroquinate synthase	ISS			PTHR43622:SF1	3-DEHYDROQUINATE SYNTHASE
P00047	PDGF signaling pathway	P01159	SOS	DICDI|dictyBase=DDB_G0274605|UniProtKB=Q8SSQ0	Ras guanine nucleotide exchange factor R	ISS			PTHR23113:SF162	RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR R
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	MONDO|Ensembl=ENSMODG00000007100|UniProtKB=F6SWY2	Uncharacterized protein	ISS	13642251	gi	PTHR15071:SF17	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
P00029	Huntington disease	P00782	alpha-Adaptin	MACMU|Ensembl=ENSMMUG00000011612|UniProtKB=F6PL38	Uncharacterized protein	ISS	11532990	PubMed	PTHR22780:SF19	AP-2 COMPLEX SUBUNIT ALPHA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00029	Huntington disease	P00775	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	TAS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P02752	Mannose metabolism	P03019	P-Mannose mutase	PANTR|Ensembl=ENSPTRG00000007748|UniProtKB=H2QAJ6	Phosphomannomutase	ISS	12477932	PubMed	PTHR10466:SF2	PHOSPHOMANNOMUTASE 2
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	BOVIN|Ensembl=ENSBTAG00000008409|UniProtKB=Q2HJ27	Myc proto-oncogene protein	ISS	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	PANTR|Ensembl=ENSPTRG00000017635|UniProtKB=H2QS64	Uncharacterized protein	ISS			PTHR10937:SF10	GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE  ISOMERIZING  2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P02769	Purine metabolism	P03119	5'-Nucleotidase	RAT|RGD=61956|UniProtKB=P21588	5'-nucleotidase	NAS	3219501	gi	PTHR11575:SF25	5'-NUCLEOTIDASE
P00048	PI3 kinase pathway	P01198	FOXO	PANTR|Ensembl=ENSPTRG00000018476|UniProtKB=H2R710	Forkhead box O3	ISS	10102273	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00034	Integrin signalling pathway	P00907	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	IDA	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000031262|UniProtKB=H2RAB4	Uncharacterized protein	ISS			PTHR43893:SF8	D 1B  DOPAMINE RECEPTOR
P00029	Huntington disease	P00774	Dynein complex	ARATH|TAIR=AT4G27360|UniProtKB=Q8VZW5	Dynein light chain type 1 family protein	IPI	9454836	PubMed	PTHR11886:SF22	DYNEIN LIGHT CHAIN TYPE 1 FAMILY PROTEIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-9966|UniProtKB=Q6TH03	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	RCA	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00053	T cell activation	P01324	rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000008867|UniProtKB=H2QCF3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95810|UniProtKB=Q9Z2W9	Glutamate receptor 3	ISS	12871085	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	XENTR|Xenbase=XB-GENE-854877|UniProtKB=F7C949	Presenilin	ISS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00021	FGF signaling pathway	P00627	ERK1-2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00025	Hedgehog signaling pathway	P00683	Slimb	HUMAN|HGNC=13607|UniProtKB=Q9UKB1	F-box/WD repeat-containing protein 11	ISS	10074433	PubMed	PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	10514528	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04393	Ras Pathway	P04541	p90RSK	MONDO|Ensembl=ENSMODG00000006241|UniProtKB=F7FRY0	Ribosomal protein S6 kinase	ISS	15526037	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	9395335	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01423	p38MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	YEAST|SGD=S000005587|UniProtKB=P19454	Casein kinase II subunit alpha'	IDA	10617630	PubMed	PTHR24054:SF27	CASEIN KINASE II SUBUNIT ALPHA'
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	EMENI|EnsemblGenome=CADANIAG00006296|UniProtKB=Q5ASG1	Putative synaptobrevin homologue SNC1/2 (Eurofung)	ISS			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00056	VEGF signaling pathway	P01408	Akt/PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	DROME|FlyBase=FBgn0087012|UniProtKB=Q8IPN2	5-hydroxytryptamine (Serotonin) receptor 2A, isoform B	IDA	11859080	PubMed	PTHR24247:SF125	5-HYDROXYTRYPTAMINE  SEROTONIN  RECEPTOR 2A, ISOFORM B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2344|UniProtKB=P08485	Muscarinic acetylcholine receptor M4	IDA	10069496	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00021	FGF signaling pathway	P00623	FGF	BOVIN|Ensembl=ENSBTAG00000006800|UniProtKB=E1BHC1	Fibroblast growth factor	ISS			PTHR11486:SF25	FIBROBLAST GROWTH FACTOR 6
P05731	GABA-B receptor II signaling	P05754	Ggamma	BOVIN|Ensembl=ENSBTAG00000000820|UniProtKB=Q5E9F0	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	ISS	2122451	PubMed	PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	TAS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BOVIN|Ensembl=ENSBTAG00000013017|UniProtKB=P04696	Guanine nucleotide-binding protein G(t) subunit alpha-2	ISS	10188796	PubMed	PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P05731	GABA-B receptor II signaling	P05755	Gbeta	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	RCA	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00005	Angiogenesis	P00203	Erk	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00012	Cadherin signaling pathway	P00466	EGFR	PANTR|Ensembl=ENSPTRG00000012883|UniProtKB=H2QJC5	Receptor protein-tyrosine kinase	ISS	4884676	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00054	Toll receptor signaling pathway	P01365	TAB1	PANTR|Ensembl=ENSPTRG00000014395|UniProtKB=H2QLQ4	Uncharacterized protein	ISS	10838074	PubMed	PTHR13832:SF533	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01026	KA	TAKRU|Ensembl=ENSTRUG00000009259|UniProtKB=H2TF39	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00053	T cell activation	P01312	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00021	FGF signaling pathway	P00643	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01179	PKB	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	BOVIN|Ensembl=ENSBTAG00000034854|UniProtKB=F1N246	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MACMU|Ensembl=ENSMMUG00000009763|UniProtKB=F6ZIC3	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF368	MYOSIN-8
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	DROME|FlyBase=FBgn0042094|UniProtKB=Q9VGU6	GTP:AMP phosphotransferase, mitochondrial	ISS			PTHR23359:SF145	GTP:AMP PHOSPHOTRANSFERASE, MITOCHONDRIAL
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	14564011	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00036	Interleukin signaling pathway	P00968	Ikk	HUMAN|HGNC=5960|UniProtKB=O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	IC	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00029	Huntington disease	P00807	Actin	CAEBR|Gene=CBG02162|UniProtKB=A8WS33	Protein CBG02162	ISS	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00019	Endothelin signaling pathway	P00566	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01448	CBP	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00056	VEGF signaling pathway	P01407	Erk	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	PANTR|Ensembl=ENSPTRG00000018511|UniProtKB=H2QTK7	Tyrosine-protein kinase	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P02738	De novo purine biosynthesis	P02898	Phosphoribosylformylglycinamide  synthase	METAC|EnsemblGenome=MA_4055|UniProtKB=Q8TIT6	Phosphoribosylformylglycinamidine synthase subunit PurL	ISS			PTHR43555:SF1	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00572	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00054	Toll receptor signaling pathway	P01380	TLR1,2,6	HUMAN|HGNC=16711|UniProtKB=Q9Y2C9	Toll-like receptor 6	ISS			PTHR24365:SF422	TOLL-LIKE RECEPTOR 6
P00052	TGF-beta signaling pathway	P01275	P38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000003236|UniProtKB=F7DNS6	Uncharacterized protein	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	XENTR|Xenbase=XB-GENE-480379|UniProtKB=Q6GL20	Frizzled homolog 10	ISS	8717036	PubMed	PTHR11309:SF86	FRIZZLED-10
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	P01438	PP2A	ANOGA|EnsemblGenome=AGAP010172|UniProtKB=Q7PD38	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00243	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00034	Integrin signalling pathway	P00931	Integrin beta	MOUSE|MGI=MGI=96612|UniProtKB=O54890	Integrin beta-3	IDA	386150	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00029	Huntington disease	P00772	FIP-2	PANTR|Ensembl=ENSPTRG00000002298|UniProtKB=H2R099	Uncharacterized protein	TAS			PTHR31553:SF2	OPTINEURIN
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00050	Plasminogen activating cascade	P01253	Fibrin	PANTR|Ensembl=ENSPTRG00000016536|UniProtKB=H2RDH7	Uncharacterized protein	ISS	80015086	PubMed	PTHR19143:SF338	FIBRINOGEN GAMMA CHAIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	PANTR|Ensembl=ENSPTRG00000001749|UniProtKB=H2Q0Q4	Uncharacterized protein	ISS	14507926	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00050	Plasminogen activating cascade	P01249	pro-tPA	HUMAN|HGNC=9051|UniProtKB=P00750	Tissue-type plasminogen activator	IDA	6572897	PubMed	PTHR44617:SF1	TISSUE-TYPE PLASMINOGEN ACTIVATOR
P02723	Adenine and hypoxanthine salvage pathway	P02809	Xanthine dehydrogenase	HUMAN|HGNC=12805|UniProtKB=P47989	Xanthine dehydrogenase/oxidase	ISS	8135849	PubMed	PTHR11908:SF80	XANTHINE DEHYDROGENASE/OXIDASE
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00805	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	HUMAN|HGNC=667|UniProtKB=P61586	Transforming protein RhoA	ISS	12039949	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05938	RhoA	XENTR|Xenbase=XB-GENE-941426|UniProtKB=Q28HZ4	Novel Rho protein	ISS	12024019	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05918	p38 MAPK pathway	P06021	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	15470041	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00010	B cell activation	P00367	NFAT	HUMAN|HGNC=7778|UniProtKB=Q14934	Nuclear factor of activated T-cells, cytoplasmic 4	IDA	12015605	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00047	PDGF signaling pathway	P01159	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P02746	Heme biosynthesis	P02981	Glutamate-1-semialdehyde aminotransferase	DEIRA|EnsemblGenome=DR_0555|UniProtKB=Q9RWW0	Glutamate-1-semialdehyde 2,1-aminomutase	ISS			PTHR43713:SF3	GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE
P00048	PI3 kinase pathway	P01188	Gbetagamma	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00310	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	RAT|RGD=3250|UniProtKB=P35465	Serine/threonine-protein kinase PAK 1	ISS	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P02788	Xanthine and guanine salvage pathway	P03250	Guanosine phosphorylase	HUMAN|HGNC=7892|UniProtKB=P00491	Purine nucleoside phosphorylase	ISS			PTHR11904:SF12	PURINE NUCLEOSIDE PHOSPHORYLASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	RAT|RGD=2155|UniProtKB=O88656	Actin-related protein 2/3 complex subunit 1B	ISS	12473693	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	SULSO|EnsemblGenome=SSO1457|UniProtKB=Q97Y81	Glutamate dehydrogenase	ISS			PTHR11606:SF13	GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00008	Axon guidance mediated by Slit/Robo	P00351	Cxcr4	HUMAN|HGNC=2561|UniProtKB=P61073	C-X-C chemokine receptor type 4	ISS	11943720	PubMed	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P00048	PI3 kinase pathway	P01188	Gbetagamma	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00034	Integrin signalling pathway	P00935	ILK	HUMAN|HGNC=6040|UniProtKB=Q13418	Integrin-linked protein kinase	ISS			PTHR44344:SF1	INTEGRIN-LINKED PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	RAT|RGD=1311108|UniProtKB=D3ZLZ7	Inosine-5'-monophosphate dehydrogenase 1	ISS			PTHR11911:SF74	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	CANLF|Gene=PSEN1|UniProtKB=Q6RH31	Presenilin-1	ISS	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P00060	Ubiquitin proteasome pathway	P01491	E2	HUMAN|HGNC=12475|UniProtKB=P62837	Ubiquitin-conjugating enzyme E2 D2	ISS			PTHR24068:SF40	UBIQUITIN-CONJUGATING ENZYME E2 D2-RELATED
P00057	Wnt signaling pathway	P01430	p53	MACMU|Ensembl=ENSMMUG00000008639|UniProtKB=P56424	Cellular tumor antigen p53	IDA	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P04393	Ras Pathway	P04567	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00052	TGF-beta signaling pathway	P01286	TGFbeta	PANTR|Ensembl=ENSPTRG00000002592|UniProtKB=H2Q215	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF159	NODAL HOMOLOG
P00017	DNA replication	P00533	Pol delta	SULSO|EnsemblGenome=SSO0081|UniProtKB=P95979	DNA polymerase 3	ISS	21332296	PubMed	PTHR10322:SF21	DNA POLYMERASE ALPHA CATALYTIC SUBUNIT
P00045	Notch signaling pathway	G01541	E(spl)-C genes	HUMAN|HGNC=4882|UniProtKB=Q9NQ87	Hairy/enhancer-of-split related with YRPW motif-like protein	IC	10860664	PubMed	PTHR10985:SF79	HAIRY/ENHANCER-OF-SPLIT RELATED WITH YRPW MOTIF-LIKE PROTEIN
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00029	Huntington disease	P00790	beta-Tubulin	SCHMA|EnsemblGenome=Smp_079970|UniProtKB=G4VTA5	Putative tubulin beta chain	ISS	12932731	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00029	Huntington disease	P00801	Fos protein	CANLF|Ensembl=ENSCAFG00000017040|UniProtKB=E2QYK5	Uncharacterized protein	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00005	Angiogenesis	P00223	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT1G73670|UniProtKB=Q9C9U4	Mitogen-activated protein kinase 15	ISS	10851062	PubMed	PTHR24055:SF246	MITOGEN-ACTIVATED PROTEIN KINASE 15-RELATED
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	HUMAN|HGNC=8528|UniProtKB=P01178	Oxytocin-neurophysin 1	ISS	1706187	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00019	Endothelin signaling pathway	P00586	Gq	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DROME|FlyBase=FBgn0031106|UniProtKB=Q9VR90	Syntaxin 16	IC			PTHR19957:SF83	SYNTAXIN-16
P00048	PI3 kinase pathway	P01182	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00005	Angiogenesis	P00233	CSL	BOVIN|Ensembl=ENSBTAG00000003602|UniProtKB=Q3SZ41	Recombining binding protein suppressor of hairless	ISS	12145413	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00056	VEGF signaling pathway	P01414	PLC-gamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00021	FGF signaling pathway	P00627	ERK1-2	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P02723	Adenine and hypoxanthine salvage pathway	P02807	Deoxyadenosine deaminase	ECOLI|EcoGene=EG10030|UniProtKB=P22333	Adenosine deaminase	ISS			PTHR11409:SF43	ADENOSINE DEAMINASE
P00006	Apoptosis signaling pathway	P00269	MAPK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	ISS	9836510	gi	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	CANLF|Gene=MYH9|UniProtKB=Q258K2	Myosin-9	ISS	89264452	PubMed	PTHR13140:SF317	MYOSIN-9
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	BOVIN|Ensembl=ENSBTAG00000000219|UniProtKB=F1MCL3	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00012	Cadherin signaling pathway	P00462	Casein kinase II	CHICK|Ensembl=ENSGALG00000000889|UniProtKB=R9PXL1	Uncharacterized protein	ISS	10617630	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00010	B cell activation	P00368	vav	PANTR|Ensembl=ENSPTRG00000021525|UniProtKB=H2QY48	Uncharacterized protein	ISS	14623913	PubMed	PTHR22826:SF95	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV2
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04398	p53 pathway feedback loops 2	P04651	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IGI	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00054	Toll receptor signaling pathway	P01375	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	ISS	10851062	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00053	T cell activation	P01332	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02746	Heme biosynthesis	P02972	Ferrochelatase	STRCO|EnsemblGenome=CAA15816|UniProtKB=O50533	Probable ferrochelatase	ISS			PTHR11108:SF1	FERROCHELATASE, MITOCHONDRIAL
P00059	p53 pathway	P04633	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IGI	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00034	Integrin signalling pathway	P00936	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IPI	96009592	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00005	Angiogenesis	P00219	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05915	Opioid proenkephalin pathway	P05994	G-protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00557	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	10799299	PubMed	PTHR10048:SF14	PI-3 KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	IDA	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00059	p53 pathway	G01581	BAX	BOVIN|Ensembl=ENSBTAG00000013340|UniProtKB=O02703	Apoptosis regulator BAX	ISS	8358790	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P00047	PDGF signaling pathway	P01167	Ets	BOVIN|Ensembl=ENSBTAG00000020594|UniProtKB=F1N599	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF10	ETS-RELATED TRANSCRIPTION FACTOR ELF-2
P00012	Cadherin signaling pathway	P00470	F-actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g188243|UniProtKB=A7SCN8	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00114	actin	HUMAN|HGNC=130|UniProtKB=P62736	Actin, aortic smooth muscle	IDA	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	PANTR|Ensembl=ENSPTRG00000017236|UniProtKB=H2QRH6	Uncharacterized protein	ISS	9118222	PubMed	PTHR10373:SF33	TRANSCRIPTION FACTOR 7
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=3710243|UniProtKB=A2AQP0	Myosin-7B	ISS	10938134	PubMed	PTHR13140:SF358	MYOSIN-7B
P00059	p53 pathway	G04694	p110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	RAT|RGD=620314|UniProtKB=B0LPN4	Ryanodine receptor 2	ISS	15858232	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	CANLF|Ensembl=ENSCAFG00000023265|UniProtKB=F1PK01	Uncharacterized protein	ISS	10851247	PubMed	PTHR11647:SF58	DIHYDROPYRIMIDINASE-RELATED PROTEIN 5
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DANRE|ZFIN=ZDB-GENE-050417-267|UniProtKB=F1QUN8	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF263	ACTIN
P00056	VEGF signaling pathway	P01408	Akt/PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1718748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00516	Ena/VASP	CANLF|Gene=VASP|UniProtKB=P50551	Vasodilator-stimulated phosphoprotein	ISS	8836115	PubMed	PTHR11202:SF12	VASODILATOR-STIMULATED PHOSPHOPROTEIN
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	HUMAN|HGNC=5291|UniProtKB=P28566	5-hydroxytryptamine receptor 1E	ISS	12181435	PubMed	PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00013	Cell cycle	P00480	Proteasome	ORNAN|Ensembl=ENSOANG00000008054|UniProtKB=F7CV41	Uncharacterized protein	ISS	12477932	PubMed	PTHR10855:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12
P00021	FGF signaling pathway	P00633	Ras	DICPU|Gene=DICPUDRAFT_51488|UniProtKB=F1A411	Putative uncharacterized protein rasC	ISS	94119591	PubMed	PTHR24070:SF251	RAS-LIKE PROTEIN RASC
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00054	Toll receptor signaling pathway	P01368	MKK2	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00036	Interleukin signaling pathway	P00996	STAT	CHICK|Ensembl=ENSGALG00000003267|UniProtKB=Q6DV79	Signal transducer and activator of transcription 3	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DANRE|ZFIN=ZDB-GENE-041210-195|UniProtKB=F1R506	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000003236|UniProtKB=F7DNS6	Uncharacterized protein	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00037	Ionotropic glutamate receptor pathway	P01026	KA	CHICK|Ensembl=ENSGALG00000002098|UniProtKB=F1P0L4	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	RCA	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00012	Cadherin signaling pathway	P00466	EGFR	MONDO|Ensembl=ENSMODG00000015755|UniProtKB=F6ZSZ9	Uncharacterized protein (Fragment)	ISS	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00018	EGF receptor signaling pathway	P00550	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12186904	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04393	Ras Pathway	P04558	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	IDA	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00053	T cell activation	P01306	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS			PTHR24072:SF248	SUBFAMILY NOT NAMED
P00002	Alpha adrenergic receptor signaling pathway	P00078	Alpha1A/1B/1C	PANTR|Ensembl=ENSPTRG00000020100|UniProtKB=H2R0T2	Uncharacterized protein	ISS	11781138	PubMed	PTHR24248:SF16	ALPHA-1A ADRENERGIC RECEPTOR
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00990	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05913	Enkephalin release	P05972	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00052	TGF-beta signaling pathway	P01284	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	YEAST|SGD=S000005738|UniProtKB=P18851	Guanine nucleotide-binding protein subunit beta	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000017256|UniProtKB=F7GWW5	Uncharacterized protein	ISS	14526084	PubMed	PTHR10037:SF137	VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1G
P00056	VEGF signaling pathway	P01423	p38MAPK	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00045	Notch signaling pathway	P01111	LNXp80	MOUSE|MGI=MGI=2155959|UniProtKB=Q91XL2	Ligand of Numb protein X 2	ISS			PTHR19964:SF33	LIGAND OF NUMB PROTEIN X 2
P00018	EGF receptor signaling pathway	P00559	MEK1-2	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	XENTR|Xenbase=XB-GENE-493706|UniProtKB=Q28IC7	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P00048	PI3 kinase pathway	P01206	14-3-3	XENTR|Xenbase=XB-GENE-970616|UniProtKB=Q6P4Z5	14-3-3 protein zeta	ISS	12861023	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00034	Integrin signalling pathway	P00920	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	HUMAN|HGNC=1401|UniProtKB=Q02641	Voltage-dependent L-type calcium channel subunit beta-1	IC	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MOUSE|MGI=MGI=95815|UniProtKB=P39087	Glutamate receptor ionotropic, kainate 2	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	MACMU|Ensembl=ENSMMUG00000014498|UniProtKB=F7GEI8	Uncharacterized protein	ISS	11976940	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P04397	p53 pathway by glucose deprivation	P04641	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008422|UniProtKB=F6VUT7	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	MOUSE|MGI=MGI=2447811|UniProtKB=A6ZI46	Fructose-bisphosphate aldolase	ISS	3391172	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	CAEEL|WormBase=WBGene00001337|UniProtKB=Q23315	Glutamyl(E) Amino-acyl tRNA Synthetase	ISS			PTHR43382:SF1	GLUTAMYL E  AMINO-ACYL TRNA SYNTHETASE
P00009	Axon guidance mediated by netrin	P00358	Ablim	HUMAN|HGNC=78|UniProtKB=O14639	Actin-binding LIM protein 1	ISS	602330	OMIM	PTHR24213:SF18	ACTIN-BINDING LIM PROTEIN 1
P05731	GABA-B receptor II signaling	P05760	AC	RAT|RGD=2036|UniProtKB=P40146	Adenylate cyclase type 8	RCA	2491850	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P04393	Ras Pathway	P04541	p90RSK	HUMAN|HGNC=10430|UniProtKB=Q15418	Ribosomal protein S6 kinase alpha-1	ISS	12213813	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00010	B cell activation	P00371	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00256	PLC-gamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00057	Wnt signaling pathway	P01457	GBeta	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00578	eNOS	CANLF|Gene=NOS3|UniProtKB=Q9TUX8	Nitric oxide synthase, endothelial	ISS	9837777	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04393	Ras Pathway	P04572	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00624	14-3-3	CAEEL|WormBase=WBGene00003920|UniProtKB=P41932	14-3-3-like protein 1	IGI	22318813	PubMed	PTHR18860:SF21	14-3-3-LIKE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	TAS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05730	Endogenous cannabinoid signaling	P05746	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00021	FGF signaling pathway	P00636	FGFR1-4	BOVIN|Ensembl=ENSBTAG00000007164|UniProtKB=F6PVB0	Fibroblast growth factor receptor	ISS			PTHR24416:SF505	FIBROBLAST GROWTH FACTOR RECEPTOR 3
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	HUMAN|HGNC=17928|UniProtKB=Q9P2W1	Homologous-pairing protein 2 homolog	ISS			PTHR15938:SF0	HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DANRE|ZFIN=ZDB-GENE-000329-3|UniProtKB=Q7ZVF9	Actin, cytoplasmic 2	ISS	3487386	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P06959	CCKR signaling map	P07228	MAPK1/3	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	RCA	7943237	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01414	PLC-gamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IGI	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00053	T cell activation	P01307	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	HUMAN|HGNC=7881|UniProtKB=P46531	Neurogenic locus notch homolog protein 1	IDA	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P05915	Opioid proenkephalin pathway	P05987	peptide F	PANTR|Ensembl=ENSPTRG00000020270|UniProtKB=H2QW70	Proenkephalin	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00029	Huntington disease	P00807	Actin	PANTR|Ensembl=ENSPTRG00000009762|UniProtKB=H2QE24	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00036	Interleukin signaling pathway	P00965	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00009	Axon guidance mediated by netrin	P00357	Netrin	CIOIN|Ensembl=ENSCING00000004654|UniProtKB=Q9NL28	Netrin	ISS			PTHR10574:SF357	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01444	Wnt	DROME|FlyBase=FBgn0010194|UniProtKB=P28466	Protein Wnt-5	IDA	11266476	PubMed	PTHR12027:SF77	PROTEIN WNT-5
P00011	Blood coagulation	P00413	HMWK	MACMU|Ensembl=ENSMMUG00000003700|UniProtKB=F6SG43	Uncharacterized protein	ISS	386852	gi	PTHR13814:SF12	KININOGEN-1
P00005	Angiogenesis	P00206	Wnt	MACMU|Ensembl=ENSMMUG00000007765|UniProtKB=F7CW57	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00013	Cell cycle	P00480	Proteasome	RAT|RGD=1594532|UniProtKB=Q4V8E2	Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14	ISS	9727008	PubMed	PTHR10410:SF5	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 14
P00047	PDGF signaling pathway	P01143	ERK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02729	Ascorbate degradation	P02849	L-xylulose kinase	DROME|FlyBase=FBgn0031279|UniProtKB=Q9VPT2	CG3544, isoform A	ISS			PTHR10196:SF57	XYLULOSE KINASE
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	RAT|RGD=621516|UniProtKB=G3V6P8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00010	B cell activation	P00391	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00558	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00052	TGF-beta signaling pathway	P01288	FKBP12	HUMAN|HGNC=3711|UniProtKB=P62942	Peptidyl-prolyl cis-trans isomerase FKBP1A	ISS	7518616	PubMed	PTHR10516:SF301	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000003043|UniProtKB=P63212	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00507	Rho	TRIAD|EnsemblGenome=TriadG20369|UniProtKB=B3RIM6	Putative uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P02742	Tetrahydrofolate biosynthesis	P02944	Phosphoribosylglycinamide formyltransferase	YEAST|SGD=S000002816|UniProtKB=P04161	Phosphoribosylglycinamide formyltransferase	ISS			PTHR43369:SF2	PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE
P05912	Dopamine receptor mediated signaling pathway	P05966	EPB41	HUMAN|HGNC=3378|UniProtKB=Q9H4G0	Band 4.1-like protein 1	IPI	12181426	PubMed	PTHR23280:SF24	BAND 4.1-LIKE PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00056	VEGF signaling pathway	P01414	PLC-gamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00005	Angiogenesis	P00219	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS			PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00018	EGF receptor signaling pathway	P00562	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	CANLF|Ensembl=ENSCAFG00000005035|UniProtKB=F1PGW4	Serine/threonine-protein kinase receptor	ISS	11252892	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	PSEAE|EnsemblGenome=PA2709|UniProtKB=Q9I0D3	Cysteine synthase	ISS			PTHR10314:SF159	CYSTEINE SYNTHASE A
P05730	Endogenous cannabinoid signaling	P05746	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DANRE|ZFIN=ZDB-GENE-000329-1|UniProtKB=Q7ZVI7	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00021	FGF signaling pathway	P00644	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00018	EGF receptor signaling pathway	P00554	Shc	MOUSE|MGI=MGI=98296|UniProtKB=P98083	SHC-transforming protein 1	IGI	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01275	P38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	TAS	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	CANLF|Ensembl=ENSCAFG00000010107|UniProtKB=E2RA74	Serine/threonine-protein kinase receptor	ISS			PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P00029	Huntington disease	P00807	Actin	MOUSE|MGI=MGI=104589|UniProtKB=P63268	Actin, gamma-enteric smooth muscle	IDA	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00021	FGF signaling pathway	P00623	FGF	XENTR|Xenbase=XB-GENE-480496|UniProtKB=F6WY95	Fibroblast growth factor (Fragment)	ISS	92315916	PubMed	PTHR11486:SF31	FIBROBLAST GROWTH FACTOR 4
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	HUMAN|HGNC=1958|UniProtKB=P43681	Neuronal acetylcholine receptor subunit alpha-4	ISS	85270494	PubMed	PTHR18945:SF401	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00045	Notch signaling pathway	P01110	Presenilin	RAT|RGD=3425|UniProtKB=P97887	Presenilin-1	IEP	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	MACMU|Ensembl=ENSMMUG00000013100|UniProtKB=F6ZUP6	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF4	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04674	Mdm2	PANTR|Ensembl=ENSPTRG00000005203|UniProtKB=H2R792	Mdm2 p53 binding protein homolog	ISS	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00015	Circadian clock system	P00504	Per	DROME|FlyBase=FBgn0003068|UniProtKB=P07663	Period circadian protein	IDA	574095	PubMed	PTHR11269:SF16	PERIOD CIRCADIAN PROTEIN
P00010	B cell activation	P00369	MEKK	BOVIN|Ensembl=ENSBTAG00000004216|UniProtKB=F1MSX4	Uncharacterized protein	ISS	8649450	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000002016|UniProtKB=F1P3G1	Protein kinase C delta type	ISS	11880265	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00045	Notch signaling pathway	G01541	E(spl)-C genes	MOUSE|MGI=MGI=1098624|UniProtKB=O54792	Transcription factor HES-2	IC			PTHR10985:SF15	TRANSCRIPTION FACTOR HES-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000000365|UniProtKB=F6R9F4	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00029	Huntington disease	P00796	Kainate receptor	MONDO|Ensembl=ENSMODG00000018065|UniProtKB=F7G485	Uncharacterized protein	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00021	FGF signaling pathway	P00641	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P06959	CCKR signaling map	G07290	MMP7	HUMAN|HGNC=7174|UniProtKB=P09237	Matrilysin	RCA	20150185	PubMed	PTHR10201:SF143	MATRILYSIN
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000002016|UniProtKB=F1P3G1	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00034	Integrin signalling pathway	P00907	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	IDA	9603989	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02748	Isoleucine biosynthesis	P02996	Ketol-acid reductoisomerase	RHOBA|EnsemblGenome=RB9869|UniProtKB=Q7UKY0	Ketol-acid reductoisomerase	ISS			PTHR21371:SF1	KETOL-ACID REDUCTOISOMERASE, CHLOROPLASTIC
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	RCA	176910	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT1G01560|UniProtKB=Q9LMM5	Mitogen-activated protein kinase 11	IDA	11707292	PubMed	PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	MOUSE|MGI=MGI=95821|UniProtKB=Q01097	Glutamate receptor ionotropic, NMDA 2B	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_127488|UniProtKB=C3XYC7	Putative uncharacterized protein	IDA	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00019	Endothelin signaling pathway	P00591	PLCbeta	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00589	Akt	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	IGI	12719720	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	IC	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	ISS	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01188	Gbetagamma	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00049	Parkinson disease	P01238	14-3-3	BOVIN|Ensembl=ENSBTAG00000000236|UniProtKB=P63103	14-3-3 protein zeta/delta	ISS	92283271	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	HUMAN|HGNC=1885|UniProtKB=P01215	Glycoprotein hormones alpha chain	ISS	15927770	PubMed	PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P00049	Parkinson disease	P01212	p38 MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=1306541|UniProtKB=D3ZVF3	Phosphoinositide-3-kinase, class 2, beta polypeptide (Predicted)	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00029	Huntington disease	P00780	Microtubule	CHICK|GeneID=396254|UniProtKB=P09244	Tubulin beta-7 chain	IDA	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P06959	CCKR signaling map	P07228	MAPK1/3	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	RCA	12488236	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02728	Arginine biosynthesis	P02840	Argininosuccinate synthase	THEMA|EnsemblGenome=TM_1780|UniProtKB=Q9X2A1	Argininosuccinate synthase	ISS			PTHR11587:SF2	ARGININOSUCCINATE SYNTHASE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00052	TGF-beta signaling pathway	P01275	P38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	TAS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00047	PDGF signaling pathway	P01154	Ras	HUMAN|HGNC=9761|UniProtKB=Q15907	Ras-related protein Rab-11B	ISS			PTHR24073:SF335	RAS-RELATED PROTEIN RAB-11B
P00029	Huntington disease	P00780	Microtubule	CAEEL|WormBase=WBGene00006539|UniProtKB=G5EF01	TuBulin, Beta	IDA	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00556	PLCgamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00029	Huntington disease	P00779	TBP	DANRE|ZFIN=ZDB-GENE-030616-563|UniProtKB=Q7SXL3	TATA-box-binding protein	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P05913	Enkephalin release	G06045	preproenkephalin	BOVIN|Ensembl=ENSBTAG00000004924|UniProtKB=P01211	Proenkephalin-A	IC	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00037	Ionotropic glutamate receptor pathway	P00999	PSD95	CAEEL|WormBase=WBGene00006444|UniProtKB=B7WN72	SHaNk (SH3/ankyrin domain scaffold protein) related	ISS	20020275	PubMed	PTHR24172:SF9	CUTICULAR PROTEIN 73D, ISOFORM B
P05917	Opioid proopiomelanocortin pathway	P06010	proopiomelanocortin	MOUSE|MGI=MGI=97742|UniProtKB=P01193	Pro-opiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IPI	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00206	Wnt	PANTR|Ensembl=ENSPTRG00000004893|UniProtKB=H2Q5U4	Protein Wnt	ISS	14644163	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g169611|UniProtKB=A7SEB1	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00059	p53 pathway	P04623	CBP	MACMU|Ensembl=ENSMMUG00000000893|UniProtKB=F6T7D0	Histone acetyltransferase p300	ISS	10664585	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02920	dCTP deaminase	YEAST|SGD=S000003572|UniProtKB=P47058	tRNA-specific adenosine deaminase subunit TAD2	ISS			PTHR11079:SF92	TRNA-SPECIFIC ADENOSINE DEAMINASE 2
P00054	Toll receptor signaling pathway	G01550	Gene trancription	HUMAN|HGNC=9605|UniProtKB=P35354	Prostaglandin G/H synthase 2	ISS	12871860	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P00011	Blood coagulation	P00440	ATIII	PANTR|Ensembl=ENSPTRG00000001701|UniProtKB=H2Q0N0	Uncharacterized protein	ISS	1082955	gi	PTHR11461:SF53	ANTITHROMBIN-III
P00004	Alzheimer disease-presenilin pathway	P00115	Nicastrin	MOUSE|MGI=MGI=1891700|UniProtKB=P57716	Nicastrin	IDA	16096062	PubMed	PTHR21092:SF0	NICASTRIN
P00018	EGF receptor signaling pathway	P00565	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01168	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	10704417	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00018	EGF receptor signaling pathway	P00552	Ras	CAEEL|WormBase=WBGene00004311|UniProtKB=G5EGA7	GTP binding protein	ISS			PTHR24070:SF268	RAS-RELATED PROTEIN M-RAS
P02775	Salvage pyrimidine ribonucleotides	P03150	Uridine kinase	YEAST|SGD=S000005295|UniProtKB=P27515	Uridine kinase	ISS			PTHR10285:SF123	URIDINE KINASE
P06587	Nicotine pharmacodynamics pathway	P06601	FLNA	RAT|RGD=1560614|UniProtKB=C0JPT7	Filamin alpha	ISS	11911837	PubMed	PTHR43998:SF6	FILAMIN-A
P00049	Parkinson disease	P01226	CDCrel-1	MOUSE|MGI=MGI=97298|UniProtKB=P42208	Septin-2	IDA			PTHR18884:SF67	SEPTIN-2
P00005	Angiogenesis	P00233	CSL	TAKRU|Ensembl=ENSTRUG00000014798|UniProtKB=H2ULI5	Uncharacterized protein	ISS	9043084	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P04398	p53 pathway feedback loops 2	P04651	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00018	EGF receptor signaling pathway	P00551	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	IGI	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00508	Cofilin	MACMU|Ensembl=ENSMMUG00000018331|UniProtKB=F7H8A1	Uncharacterized protein	ISS			PTHR11913:SF15	COFILIN-2
P00045	Notch signaling pathway	P01114	Ntm	CANLF|Ensembl=ENSCAFG00000019633|UniProtKB=F1PDC7	Uncharacterized protein	ISS	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CANLF|Ensembl=ENSCAFG00000013148|UniProtKB=Q5R1P3	Glutamate receptor ionotropic, NMDA 2B	IC	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00019	Endothelin signaling pathway	P00591	PLCbeta	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IGI	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00759	PDEalphabeta	RAT|RGD=1306835|UniProtKB=D3Z8C9	Phosphodiesterase	ISS	7493036	PubMed	PTHR11347:SF115	ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA
P00059	p53 pathway	P01486	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00018	EGF receptor signaling pathway	P00554	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	7680960	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04559	Rac	DICDI|dictyBase=DDB_G0279605|UniProtKB=P34148	Rho-related protein racB	ISS	12932731	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00034	Integrin signalling pathway	P00931	Integrin beta	BOVIN|Ensembl=ENSBTAG00000009987|UniProtKB=F1MTN1	Integrin beta	ISS	7949057	gi	PTHR10082:SF25	INTEGRIN BETA-3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00006	Apoptosis signaling pathway	P00313	IKK	BOVIN|Ensembl=ENSBTAG00000007599|UniProtKB=Q95KV0	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00047	PDGF signaling pathway	P01150	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000004742|UniProtKB=H2Q5K1	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P00010	B cell activation	P00397	IKK	PANTR|Ensembl=ENSPTRG00000020202|UniProtKB=H2QW34	Uncharacterized protein	ISS	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P04393	Ras Pathway	P04541	p90RSK	ORNAN|Ensembl=ENSOANG00000010658|UniProtKB=F6V2V1	Uncharacterized protein	ISS	10480933	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000000985|UniProtKB=F6VRS9	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	TAS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00034	Integrin signalling pathway	P00927	Rac	DICDI|dictyBase=DDB_G0293526|UniProtKB=P34149	Rho-related protein racC	IGI	94124042	PubMed	PTHR24072:SF117	RHO-RELATED PROTEIN RACC
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IC	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00047	PDGF signaling pathway	P01162	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00632	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IGI	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01177	P110ACT	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MOUSE|MGI=MGI=109248|UniProtKB=Q920H4	Muscarinic acetylcholine receptor M5	IDA	10069496	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IC	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00942	Fyn	MACMU|Ensembl=ENSMMUG00000017017|UniProtKB=F7FVL2	Tyrosine-protein kinase	ISS	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000017338|UniProtKB=H2QRN3	Protocadherin beta-17	ISS	8120095	PubMed	PTHR24028:SF71	PROTOCADHERIN BETA-16
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	XENTR|Xenbase=XB-GENE-484003|UniProtKB=Q6P365	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	BOVIN|Ensembl=ENSBTAG00000021741|UniProtKB=F1MNR5	Ribosomal protein S6 kinase	ISS	15526037	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00047	PDGF signaling pathway	P01171	PLCgamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00036	Interleukin signaling pathway	P00974	Receptor subunit beta	MOUSE|MGI=MGI=1339760|UniProtKB=P26954	Interleukin-3 receptor class 2 subunit beta	ISS	1386365	PubMed	PTHR23037:SF22	CYTOKINE RECEPTOR COMMON SUBUNIT BETA
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00038	JAK/STAT signaling pathway	P01027	STAT	MACMU|Ensembl=ENSMMUG00000010707|UniProtKB=F7G8G5	Signal transducer and activator of transcription	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00025	Hedgehog signaling pathway	P00690	Cubitus interruptus	RAT|RGD=621673|UniProtKB=G3V6X8	GLI-Kruppel family member GLI1	ISS			PTHR19818:SF2	ZINC FINGER PROTEIN GLI1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IC	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00059	p53 pathway	P04616	PDK1/2	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	TAS	11256888	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00053	T cell activation	P01320	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	DANRE|ZFIN=ZDB-GENE-051202-2|UniProtKB=Q6ZM67	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF3	SUBFAMILY NOT NAMED
P06587	Nicotine pharmacodynamics pathway	P06606	ADCY2	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	RCA	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00920	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	BOVIN|Ensembl=ENSBTAG00000014710|UniProtKB=P62833	Ras-related protein Rap-1A	ISS	10476970	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00057	Wnt signaling pathway	P01451	Galpha	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05913	Enkephalin release	P05977	G-Protein (s)	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00034	Integrin signalling pathway	P00920	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00898	FKHR	BOVIN|Ensembl=ENSBTAG00000011234|UniProtKB=F1N4K5	Uncharacterized protein	ISS	12884295	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	CHICK|Ensembl=ENSGALG00000002003|UniProtKB=F1P3H0	Receptor protein serine/threonine kinase	IDA			PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	ANOGA|EnsemblGenome=AGAP001394|UniProtKB=F5HMS4	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00012	Cadherin signaling pathway	P00474	Wnt	PANTR|Ensembl=ENSPTRG00000004519|UniProtKB=H2Q569	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	TAS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	MOUSE|MGI=MGI=2651588|UniProtKB=Q8VHQ2	Suppressor of cytokine signaling 7	TAS	12645661	PubMed	PTHR45052:SF1	SUPPRESSOR OF CYTOKINE SIGNALING 7
P00005	Angiogenesis	P00206	Wnt	XENTR|Xenbase=XB-GENE-960148|UniProtKB=F6XMD3	Protein Wnt (Fragment)	ISS	8717036	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000002016|UniProtKB=F1P3G1	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05941	GRK3	TAKRU|Ensembl=ENSTRUG00000018612|UniProtKB=H2VEM3	Protein-serine/threonine kinase	ISS	10852916	PubMed	PTHR24355:SF18	PROTEIN-SERINE/THREONINE KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00018	EGF receptor signaling pathway	P00550	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	9763606	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00036	Interleukin signaling pathway	P00968	Ikk	HUMAN|HGNC=5960|UniProtKB=O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	IC	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00564	Rac	ENTHI|EnsemblGenome=EHI_181250|UniProtKB=C4M5Z7	Rho family GTPase	IGI	12932731	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00029	Huntington disease	P00805	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02727	Androgen/estrogene/progesterone biosynthesis	P02829	Cholesterol acyltransferase	PLAF7|EnsemblGenome=PFC0995c|UniProtKB=O97295	O-acyltransferase	ISS			PTHR10408:SF7	DIACYLGLYCEROL O-ACYLTRANSFERASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01316	MHC-antigen	BOVIN|Ensembl=ENSBTAG00000037605|UniProtKB=F6Q9J4	Uncharacterized protein	IPI	73139	PubMed	PTHR19944:SF59	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DQ ALPHA 1 CHAIN
P00006	Apoptosis signaling pathway	P00310	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=109356|UniProtKB=O09044	Synaptosomal-associated protein 23	IC	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00053	T cell activation	P01331	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IPI	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	IXOSC|EnsemblGenome=ISCW014549|UniProtKB=B7QGY5	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	MOUSE|MGI=MGI=109161|UniProtKB=Q8VEB1	G protein-coupled receptor kinase 5	IDA	8288567	PubMed	PTHR24355:SF27	G PROTEIN-COUPLED RECEPTOR KINASE 5
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8971|UniProtKB=O00443	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00729	Goalpha	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00965	ERK	PANTR|Ensembl=ENSPTRG00000008867|UniProtKB=H2QCF3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00037	Ionotropic glutamate receptor pathway	P01026	KA	CHICK|Ensembl=ENSGALG00000015835|UniProtKB=F1NZT2	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00219	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05913	Enkephalin release	P05974	G-Protein (i)	CAEEL|WormBase=WBGene00001680|UniProtKB=Q20636	Guanine nucleotide-binding protein subunit beta-2	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00047	PDGF signaling pathway	P01142	p90RSK	HUMAN|HGNC=10430|UniProtKB=Q15418	Ribosomal protein S6 kinase alpha-1	ISS	12769834	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00038	JAK/STAT signaling pathway	P01034	Jak	BOVIN|Ensembl=ENSBTAG00000012047|UniProtKB=E1BCP6	Tyrosine-protein kinase	ISS	22482294	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	PANTR|Ensembl=ENSPTRG00000002979|UniProtKB=H2Q2M8	Uncharacterized protein	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01431	LRP5/6	ORNAN|Ensembl=ENSOANG00000006877|UniProtKB=F7CQF2	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00059	p53 pathway	P01480	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00054	Toll receptor signaling pathway	P01381	Ubc13	PANTR|Ensembl=ENSPTRG00000028180|UniProtKB=H2R4I1	Uncharacterized protein	ISS			PTHR43902:SF3	UBIQUITIN-CONJUGATING ENZYME E2 N-LIKE-RELATED
P00006	Apoptosis signaling pathway	P00289	FAS	MOUSE|MGI=MGI=95484|UniProtKB=P25446	Tumor necrosis factor receptor superfamily member 6	ISS	14585074	PubMed	PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P00029	Huntington disease	P00775	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	20264070	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00021	FGF signaling pathway	P00633	Ras	DANRE|ZFIN=ZDB-GENE-990415-166|UniProtKB=P79737	GTPase NRas	ISS	9116869	PubMed	PTHR24070:SF189	GTPASE NRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Gene=DRD2|UniProtKB=Q9GJU1	D(2) dopamine receptor	IDA	2039532	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00030	Hypoxia response via HIF activation	P00823	PI3K	DROME|FlyBase=FBgn0015278|UniProtKB=Q7K3H0	LD28067p	ISS			PTHR10048:SF64	LD28067P
P00006	Apoptosis signaling pathway	P00310	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00030	Hypoxia response via HIF activation	P00819	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00302	ATF	HUMAN|HGNC=2352|UniProtKB=Q03060	cAMP-responsive element modulator	ISS			PTHR22952:SF97	CAMP-RESPONSIVE ELEMENT MODULATOR
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IDA	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00056	VEGF signaling pathway	P01410	Caspase9	HUMAN|HGNC=1511|UniProtKB=P55211	Caspase-9	IDA	11440972	PubMed	PTHR10454:SF157	CASPASE-9
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	TAKRU|Ensembl=ENSTRUG00000010005|UniProtKB=H2TKG8	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00034	Integrin signalling pathway	P00948	Rho	HUMAN|HGNC=669|UniProtKB=P08134	Rho-related GTP-binding protein RhoC	ISS	12090470	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00012	Cadherin signaling pathway	P00465	TCF/LEF	MOUSE|MGI=MGI=1202879|UniProtKB=Q924A0	Transcription factor 7-like 2	ISS	11266476	PubMed	PTHR10373:SF32	TRANSCRIPTION FACTOR 7-LIKE 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00890	ELK	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	ISS	10487205	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	TAKRU|Ensembl=ENSTRUG00000015413|UniProtKB=H2UR30	Uncharacterized protein	ISS			PTHR11681:SF13	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00632	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01203	p101	MACMU|Ensembl=ENSMMUG00000005792|UniProtKB=F6VTR8	Uncharacterized protein	ISS	12507995	PubMed	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00018	EGF receptor signaling pathway	P00558	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	IGI	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00057	Wnt signaling pathway	P01440	Cadherin	CANLF|Ensembl=ENSCAFG00000011398|UniProtKB=E2QX22	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF272	CADHERIN-24
P00047	PDGF signaling pathway	P01159	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05734	Synaptic vesicle trafficking	P05774	NSF	DROME|FlyBase=FBgn0266464|UniProtKB=P54351	Vesicle-fusing ATPase 2	TAS	601633	OMIM	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00057	Wnt signaling pathway	P01428	Frizzled	ORNAN|Ensembl=ENSOANG00000004982|UniProtKB=F7DIA9	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF34	FRIZZLED-2
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00054	Toll receptor signaling pathway	P01369	MKK1	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00047	PDGF signaling pathway	P01153	GSK3	DANRE|ZFIN=ZDB-GENE-990714-3|UniProtKB=Q9YH61	Glycogen synthase kinase 3 alpha	ISS	11995474	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00057	Wnt signaling pathway	P01435	SWI/SNF	PANTR|Ensembl=ENSPTRG00000009526|UniProtKB=H2QDN6	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2	ISS	11532957	PubMed	PTHR13844:SF2	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D MEMBER 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	NEUCR|EnsemblGenome=EFNCRG00000000159|UniProtKB=F5HH30	Guanine nucleotide-binding protein beta subunit	IC	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	PANTR|Ensembl=ENSPTRG00000001477|UniProtKB=H2Q0A5	Tyrosine-protein kinase receptor	ISS	11182407	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02729	Ascorbate degradation	P02849	L-xylulose kinase	BACSU|EnsemblGenome=BSU18550|UniProtKB=O34861	Putative sugar kinase YoaC	ISS			PTHR43095:SF1	AUTOINDUCER-2 KINASE
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IDA	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	CHICK|Ensembl=ENSGALG00000006885|UniProtKB=P08642	GTPase HRas	ISS	3035212	PubMed	PTHR24070:SF385	GTPASE HRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	ARATH|TAIR=AT1G01560|UniProtKB=Q9LMM5	Mitogen-activated protein kinase 11	TAS			PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00038	JAK/STAT signaling pathway	P01027	STAT	BOVIN|Ensembl=ENSBTAG00000006335|UniProtKB=F1MGJ4	Signal transducer and activator of transcription	ISS	8085155	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00048	PI3 kinase pathway	G01546	Cyclin d	HUMAN|HGNC=1583|UniProtKB=P30279	G1/S-specific cyclin-D2	ISS	93275661	PubMed	PTHR10177:SF66	G1/S-SPECIFIC CYCLIN-D2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00049	Parkinson disease	P01230	Src kinase	HUMAN|HGNC=6524|UniProtKB=P06239	Tyrosine-protein kinase Lck	IDA	11078745	PubMed	PTHR24418:SF39	TYROSINE-PROTEIN KINASE LCK
P02751	Lysine biosynthesis	P03013	Aspartate semialdehyde dehydrogenase	DEIRA|EnsemblGenome=DR_2008|UniProtKB=Q9RSW3	Aspartate-semialdehyde dehydrogenase	ISS			PTHR10174:SF2	ASPARTATE-SEMIALDEHYDE DEHYDROGENASE
P00053	T cell activation	P01318	PKC-theta	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	DANRE|ZFIN=ZDB-GENE-990415-162|UniProtKB=P52160	Transcriptional regulator Myc-A	IEP	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04396	Vitamin D metabolism and pathway	P04601	25-Hydroxylase	MOUSE|MGI=MGI=1098274|UniProtKB=O35084	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	ISS	11013342	PubMed	PTHR24291:SF3	25-HYDROXYVITAMIN D-1 ALPHA HYDROXYLASE, MITOCHONDRIAL
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04665	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00024	Glycolysis	P00679	Aldolase	BOVIN|Ensembl=ENSBTAG00000012927|UniProtKB=A6QLL8	Fructose-bisphosphate aldolase	ISS	4812352	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00018	EGF receptor signaling pathway	P00554	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	8264585	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P06959	CCKR signaling map	P07166	MAPK1	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	RCA	12239223	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00007	Axon guidance mediated by semaphorins	P00334	PlexinA1	BOVIN|Ensembl=ENSBTAG00000009159|UniProtKB=E1BFR4	Uncharacterized protein	ISS	10520995	PubMed	PTHR22625:SF35	PLEXIN-A1
P00053	T cell activation	P01312	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00019	Endothelin signaling pathway	P00583	cPLA2	RAT|RGD=67366|UniProtKB=P50393	Cytosolic phospholipase A2	IGI	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	IC	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P02754	Methylcitrate cycle	P03028	Aconitase	PANTR|Ensembl=ENSPTRG00000007342|UniProtKB=H2Q9W5	Iron-responsive element binding protein 2	ISS			PTHR11670:SF31	IRON-RESPONSIVE ELEMENT-BINDING PROTEIN 2
P00005	Angiogenesis	P00206	Wnt	DANRE|ZFIN=ZDB-GENE-980526-87|UniProtKB=Q92050	Protein Wnt-5b	ISS	8717036	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05730	Endogenous cannabinoid signaling	P05746	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	SULSO|EnsemblGenome=SSO0951|UniProtKB=P58178	TATA-box-binding protein	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00021	FGF signaling pathway	P00628	JNK1-3	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00029	Huntington disease	P00810	GAPDH	XENTR|Ensembl=ENSXETG00000033975|UniProtKB=Q28HJ8	Glyceraldehyde-3-phosphate dehydrogenase	ISS	8612237	PubMed	PTHR10836:SF51	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE
P02736	Coenzyme A biosynthesis	P02884	Dephospho-CoA kinase	DEIRA|EnsemblGenome=DR_1892|UniProtKB=Q9RT73	Dephospho-CoA kinase	ISS			PTHR10695:SF26	BIFUNCTIONAL COENZYME A SYNTHASE
P00018	EGF receptor signaling pathway	P00541	Spry	MOUSE|MGI=MGI=1345139|UniProtKB=Q9QXV9	Protein sprouty homolog 1	IGI	12882970	PubMed	PTHR12365:SF10	PROTEIN SPROUTY HOMOLOG 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000010521|UniProtKB=F7DQK7	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=2652894|UniProtKB=Q80Y86	Mitogen-activated protein kinase 15	ISS	10514528	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MONDO|Ensembl=ENSMODG00000008463|UniProtKB=F7GET1	Uncharacterized protein	ISS	21240406	PubMed	PTHR10845:SF196	REGULATOR OF G-PROTEIN SIGNALING 17
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00049	Parkinson disease	P01238	14-3-3	MOUSE|MGI=MGI=109194|UniProtKB=P68510	14-3-3 protein eta	IDA	6756037	gi	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00005	Angiogenesis	P00182	p38MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008026|UniProtKB=H2QAZ2	Syntaxin 1B	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	HUMAN|HGNC=4588|UniProtKB=O15399	Glutamate receptor ionotropic, NMDA 2D	IC	11319238	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00056	VEGF signaling pathway	P01417	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01332	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00081	Pro-BACE-1	HUMAN|HGNC=933|UniProtKB=P56817	Beta-secretase 1	IDA	10531052	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00034	Integrin signalling pathway	P00907	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00562	p38	DROME|FlyBase=FBgn0024846|UniProtKB=O61443	Mitogen-activated protein kinase 14B	ISS	10514528	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P02749	Leucine biosynthesis	P03001	3-Isopropylmalate dehydrogenase	PSEAE|EnsemblGenome=PA3118|UniProtKB=Q51375	3-isopropylmalate dehydrogenase	ISS			PTHR42979:SF1	3-ISOPROPYLMALATE DEHYDROGENASE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00475	Frizzled	CHICK|Gene=FZD10|UniProtKB=Q9PWH2	Frizzled-10	IDA	8717036	PubMed	PTHR11309:SF86	FRIZZLED-10
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00210	eNOS	MOUSE|MGI=MGI=97362|UniProtKB=P70313	Nitric oxide synthase, endothelial	ISS	10435050	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00019	Endothelin signaling pathway	P00576	Pre-pro ET1-4	RAT|RGD=2532|UniProtKB=P22388	Endothelin-1	ISS	15117818	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	BOVIN|Ensembl=ENSBTAG00000005326|UniProtKB=P67827	Casein kinase I isoform alpha	ISS	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	BOVIN|Ensembl=ENSBTAG00000037726|UniProtKB=P10895	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	10934033	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IPI	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00009	Axon guidance mediated by netrin	P00361	Ena	HUMAN|HGNC=12652|UniProtKB=P50552	Vasodilator-stimulated phosphoprotein	RCA			PTHR11202:SF12	VASODILATOR-STIMULATED PHOSPHOPROTEIN
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	DROME|FlyBase=FBgn0031995|UniProtKB=Q9VLS1	Probable phosphorylase b kinase regulatory subunit beta	IDA	10487978	PubMed	PTHR10749:SF8	PHOSPHORYLASE B KINASE REGULATORY SUBUNIT BETA
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P06959	CCKR signaling map	P07167	FOXO1	HUMAN|HGNC=3819|UniProtKB=Q12778	Forkhead box protein O1	RCA	15351698	PubMed	PTHR11829:SF159	FORKHEAD BOX PROTEIN O1
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	RAT|RGD=621109|UniProtKB=O88321	Antisecretory factor	ISS	13645506	gi	PTHR10223:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4
P00047	PDGF signaling pathway	P01159	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DICDI|dictyBase=DDB_G0275023|UniProtKB=Q553U6	Putative actin-22	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=102705|UniProtKB=P63213	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00057	Wnt signaling pathway	P01457	GBeta	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00021	FGF signaling pathway	P00632	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	IGI	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02748	Isoleucine biosynthesis	P02997	Acetolactate synthase	ARATH|TAIR=AT3G48560|UniProtKB=P17597	Acetolactate synthase, chloroplastic	ISS			PTHR18968:SF112	ACETOLACTATE SYNTHASE, CHLOROPLASTIC
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	DROME|FlyBase=FBgn0052301|UniProtKB=Q9W037	Uncharacterized protein, isoform C	ISS			PTHR11920:SF338	ACXA, ISOFORM A-RELATED
P04384	Gamma-aminobutyric acid synthesis	P04480	GABA aminotransferase	CANLF|Ensembl=ENSCAFG00000019030|UniProtKB=E2R776	Uncharacterized protein	ISS	2496985	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00014	Cholesterol biosynthesis	P00490	Dimethylallyl trans-transferase	MOUSE|MGI=MGI=1341724|UniProtKB=Q9WTN0	Geranylgeranyl pyrophosphate synthase	RCA			PTHR12001:SF44	GERANYLGERANYL PYROPHOSPHATE SYNTHASE
P00017	DNA replication	P00534	PCNA	MOUSE|MGI=MGI=97503|UniProtKB=P17918	Proliferating cell nuclear antigen	ISS	12893285	PubMed	PTHR11352:SF0	PROLIFERATING CELL NUCLEAR ANTIGEN
P00029	Huntington disease	P00805	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01440	Cadherin	XENTR|Xenbase=XB-GENE-5887886|UniProtKB=F6VDD4	Uncharacterized protein (Fragment)	ISS	8120095	PubMed	PTHR24028:SF46	PROTOCADHERIN-8
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00050	Plasminogen activating cascade	P01250	MMP-13	PANTR|Ensembl=ENSPTRG00000004222|UniProtKB=H2Q4N4	Uncharacterized protein	ISS	8207000	PubMed	PTHR10201:SF165	COLLAGENASE 3
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00009	Axon guidance mediated by netrin	P00366	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	1764995	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	IC	8836152	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=1303000|UniProtKB=Q75NI5	Cadherin 15	ISS	8120095	PubMed	PTHR24027:SF300	CADHERIN-15
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	MACMU|Ensembl=ENSMMUG00000014555|UniProtKB=F7GT55	Syntaxin-1A isoform 1	ISS	1321498	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00054	Toll receptor signaling pathway	P01358	ERK1	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00034	Integrin signalling pathway	P00922	Collagen	XENTR|Xenbase=XB-GENE-6258379|UniProtKB=L7N2N3	Uncharacterized protein	ISS	10778855	PubMed	PTHR24023:SF569	COLLAGEN ALPHA-1 I  CHAIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	IDA	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00025	Hedgehog signaling pathway	P00692	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00045	Notch signaling pathway	P01113	Pen-2	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	ISS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P02755	Methylmalonyl pathway	P03032	Methylmalonyl-CoA epimerase	PANTR|Ensembl=ENSPTRG00000012044|UniProtKB=H2QI34	Uncharacterized protein	ISS			PTHR43048:SF3	METHYLMALONYL-COA EPIMERASE, MITOCHONDRIAL
P00021	FGF signaling pathway	P00645	Rac	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS	12606638	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00023	General transcription regulation	P00658	TBP-associated factors	MONDO|Ensembl=ENSMODG00000012785|UniProtKB=F6S0M5	Uncharacterized protein	ISS	604904	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01161	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00037	Ionotropic glutamate receptor pathway	P01015	Glu4	MONDO|Ensembl=ENSMODG00000014746|UniProtKB=F6YN64	Uncharacterized protein (Fragment)	ISS	12871085	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=1306348|UniProtKB=F1LS01	Protein Pcdh9	ISS	8120095	PubMed	PTHR43912:SF5	PROTOCADHERIN-9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IDA	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	ARATH|TAIR=AT1G48470|UniProtKB=Q8GXW5	Glutamine synthetase cytosolic isozyme 1-5	ISS			PTHR20852:SF79	GLUTAMINE SYNTHETASE CYTOSOLIC ISOZYME 1-1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MACMU|Ensembl=ENSMMUG00000019351|UniProtKB=Q2YEG0	C-X-C chemokine receptor type 1	ISS	1840701	PubMed	PTHR10489:SF916	C-X-C CHEMOKINE RECEPTOR TYPE 1
P00029	Huntington disease	P00774	Dynein complex	CANLF|Ensembl=ENSCAFG00000005390|UniProtKB=E2RH71	Uncharacterized protein	ISS	9454836	PubMed	PTHR12688:SF2	CYTOPLASMIC DYNEIN 1 LIGHT INTERMEDIATE CHAIN 1
P00052	TGF-beta signaling pathway	P01284	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MONDO|Ensembl=ENSMODG00000000771|UniProtKB=F6SSS3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=18539|UniProtKB=P61266	Syntaxin-1B	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00029	Huntington disease	P00780	Microtubule	MACMU|Ensembl=ENSMMUG00000032572|UniProtKB=F7D7Y7	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00833	RGS	MOUSE|MGI=MGI=1859709|UniProtKB=P97492	Regulator of G-protein signaling 14	IDA	10779778	PubMed	PTHR10845:SF179	REGULATOR OF G-PROTEIN SIGNALING 14
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MACMU|Ensembl=ENSMMUG00000019305|UniProtKB=F6S3T8	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P06959	CCKR signaling map	G06978	CHGA	HUMAN|HGNC=1929|UniProtKB=P10645	Chromogranin-A	RCA	12456801	PubMed	PTHR10583:SF1	CHROMOGRANIN-A
P00013	Cell cycle	P00480	Proteasome	CANLF|Ensembl=ENSCAFG00000011453|UniProtKB=J9JHD9	Uncharacterized protein	ISS	9426256	PubMed	PTHR10855:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12
P00010	B cell activation	P00384	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	12810719	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00018	EGF receptor signaling pathway	P00558	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	RAT|RGD=2742|UniProtKB=P23385	Metabotropic glutamate receptor 1	ISS	12488551	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00973	PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00546	GAP	RAT|RGD=3168|UniProtKB=P97526	Neurofibromin	ISS	18587532	gi	PTHR10194:SF60	NEUROFIBROMIN
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	MOUSE|MGI=MGI=107428|UniProtKB=Q8BTU1	Cilia- and flagella-associated protein 20	ISS			PTHR12458:SF8	CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008018|UniProtKB=F7EPG4	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00034	Integrin signalling pathway	P00936	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04375	5HT3 type receptor mediated signaling pathway	P04421	5HT transporter	BOVIN|Gene=SLC6A4|UniProtKB=Q9XT49	Sodium-dependent serotonin transporter	ISS	14653308	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P04393	Ras Pathway	P04542	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01153	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	CHICK|Ensembl=ENSGALG00000007509|UniProtKB=F1NM72	Uncharacterized protein	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P02769	Purine metabolism	P03116	Xanthine Oxidase	HUMAN|HGNC=12805|UniProtKB=P47989	Xanthine dehydrogenase/oxidase	ISS	12969896	PubMed	PTHR11908:SF80	XANTHINE DEHYDROGENASE/OXIDASE
P00010	B cell activation	P00384	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00019	Endothelin signaling pathway	P00567	PKG	PANTR|Ensembl=ENSPTRG00000002509|UniProtKB=H2Q1X0	cGMP-dependent protein kinase	ISS	10565812	PubMed	PTHR24353:SF68	SUBFAMILY NOT NAMED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00053	T cell activation	P01324	rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12912997	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00010	B cell activation	P00375	Calmodulin	RAT|RGD=2257|UniProtKB=P62161	Calmodulin	ISS	7514101	PubMed	PTHR23050:SF311	CALMODULIN
P00004	Alzheimer disease-presenilin pathway	P00114	actin	SCHPO|PomBase=SPBC32H8.12c|UniProtKB=P10989	Actin	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	IC	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IDA	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00010	B cell activation	P00402	Jnk	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00036	Interleukin signaling pathway	P00990	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00547	PP2A	HUMAN|HGNC=9300|UniProtKB=P62714	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	IGI	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00243	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01052	AC	RAT|RGD=708450|UniProtKB=Q9Z286	Adenylate cyclase type 10	ISS	11744988	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P00057	Wnt signaling pathway	P01433	SIAH-1	MOUSE|MGI=MGI=108062|UniProtKB=Q06986	E3 ubiquitin-protein ligase SIAH2	IDA			PTHR10315:SF11	E3 UBIQUITIN-PROTEIN LIGASE SIAH2
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00005	Angiogenesis	P00226	Delta/Serrate	DANRE|ZFIN=ZDB-GENE-011128-4|UniProtKB=Q90Y54	Protein jagged-1b	ISS			PTHR44097:SF3	PROTEIN JAGGED-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MACMU|Ensembl=ENSMMUG00000031972|UniProtKB=F7GWC3	Actin-related protein 2/3 complex subunit 4	ISS	5031595	gi	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00059	p53 pathway	P01486	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	RAT|RGD=1595475|UniProtKB=D4AAI1	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF26	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT GAMMA-T1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	DANRE|ZFIN=ZDB-GENE-030616-382|UniProtKB=B5LZ08	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF18	PROTEIN-SERINE/THREONINE KINASE
P00036	Interleukin signaling pathway	P00983	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00034	Integrin signalling pathway	P00947	Laminin	HUMAN|HGNC=6490|UniProtKB=Q13751	Laminin subunit beta-3	IPI	2538453	PubMed	PTHR10574:SF268	LAMININ SUBUNIT BETA-3
P05734	Synaptic vesicle trafficking	P05780	Rab3A	RAT|RGD=3528|UniProtKB=P63012	Ras-related protein Rab-3A	ISS	9194562	PubMed	PTHR24073:SF532	RAS-RELATED PROTEIN RAB-3A
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	BOVIN|Ensembl=ENSBTAG00000000219|UniProtKB=F1MCL3	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000016097|UniProtKB=E1B9S9	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00004	Alzheimer disease-presenilin pathway	P00118	E-cadherin	XENTR|Xenbase=XB-GENE-482277|UniProtKB=F6QAX3	Uncharacterized protein	ISS	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P05913	Enkephalin release	G06046	preproenkephalin mRNA	HUMAN|HGNC=8831|UniProtKB=P01210	Proenkephalin-A	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_114976|UniProtKB=C3YP58	Putative uncharacterized protein	IDA	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00010	B cell activation	P00391	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00025	Hedgehog signaling pathway	P00682	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P02738	De novo purine biosynthesis	P02903	Phosphoribosylglycinamide  formyltransferase	SCHPO|PomBase=SPCC569.08c|UniProtKB=Q9UUK7	Phosphoribosylglycinamide formyltransferase	ISS			PTHR43369:SF2	PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	MACMU|Ensembl=ENSMMUG00000021423|UniProtKB=F7EEZ1	Phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00012	Cadherin signaling pathway	P00470	F-actin	SCHMA|EnsemblGenome=Smp_161920|UniProtKB=G4VSW5	Putative actin	IC	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00877	MLCK	HUMAN|HGNC=7590|UniProtKB=Q15746	Myosin light chain kinase, smooth muscle	IDA	11157482	PubMed	PTHR45480:SF1	MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008026|UniProtKB=H2QAZ2	Syntaxin 1B	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00049	Parkinson disease	P01219	SAPK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01095	beta	BOVIN|Gene=CHRNB4|UniProtKB=Q8SPU6	Neuronal acetylcholine receptor subunit beta-4	ISS	22213672	PubMed	PTHR18945:SF385	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-4
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00013	Cell cycle	P00489	CdkC	MOUSE|MGI=MGI=1329034|UniProtKB=Q9Z238	G1/S-specific cyclin-E2	RCA			PTHR10177:SF70	G1/S-SPECIFIC CYCLIN-E2
P02736	Coenzyme A biosynthesis	P02885	Pantothenate kinase	CAEEL|WormBase=WBGene00004068|UniProtKB=H2KYP7	PaNtothenate Kinase	ISS			PTHR12280:SF20	PANTOTHENATE KINASE 4
P00021	FGF signaling pathway	P00629	PP2A	RAT|RGD=6503746|UniProtKB=Q80W83	Protein LOC100909468	ISS	10092233	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P00010	B cell activation	P00383	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00023	General transcription regulation	P00666	TFIIE	MOUSE|MGI=MGI=1921447|UniProtKB=Q9D0D5	General transcription factor IIE subunit 1	ISS	189964	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P05915	Opioid proenkephalin pathway	P05993	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	ISS	8557110	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00023	General transcription regulation	P00662	TFIIA complex	RAT|RGD=620720|UniProtKB=O08950	Transcription initiation factor IIA subunit 2	ISS			PTHR10966:SF0	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00055	Transcription regulation by bZIP transcription factor	P01396	TFIIFbeta	MOUSE|MGI=MGI=1915955|UniProtKB=Q8R0A0	General transcription factor IIF subunit 2	ISS	92020241	PubMed	PTHR10445:SF0	GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2
P00034	Integrin signalling pathway	P00925	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00006	Apoptosis signaling pathway	P00260	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00466	EGFR	HUMAN|HGNC=3432|UniProtKB=Q15303	Receptor tyrosine-protein kinase erbB-4	ISS	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	RAT|RGD=2845|UniProtKB=P19327	5-hydroxytryptamine receptor 1A	IDA			PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	PANTR|Ensembl=ENSPTRG00000003974|UniProtKB=H2R571	Uncharacterized protein	ISS			PTHR43570:SF6	ALDEHYDE DEHYDROGENASE FAMILY 3 MEMBER B2
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00050	Plasminogen activating cascade	P01253	Fibrin	HUMAN|HGNC=3662|UniProtKB=P02675	Fibrinogen beta chain	IDA	6575700	PubMed	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	XENTR|Xenbase=XB-GENE-491433|UniProtKB=B1H2U0	Pten protein	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00048	PI3 kinase pathway	P01196	PDK1	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	IDA	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00005	Angiogenesis	P00219	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS			PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	MACMU|Ensembl=ENSMMUG00000022596|UniProtKB=F6Z7T2	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF5	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 1
P00034	Integrin signalling pathway	P00924	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IPI	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00313	IKK	BOVIN|Ensembl=ENSBTAG00000007599|UniProtKB=Q95KV0	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	MONDO|Ensembl=ENSMODG00000012785|UniProtKB=F6S0M5	Uncharacterized protein	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MACMU|Ensembl=ENSMMUG00000009341|UniProtKB=F6UA54	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00049	Parkinson disease	P01242	Casein kinase I	YEAST|SGD=S000005098|UniProtKB=P23292	Casein kinase I homolog 2	IDA	11437445	PubMed	PTHR11909:SF117	CASEIN KINASE I HOMOLOG 1-RELATED
P04395	Vasopressin synthesis	P04589	Signal Peptidase	MACMU|Ensembl=ENSMMUG00000023608|UniProtKB=F7HD92	Uncharacterized protein	ISS	7788527	PubMed	PTHR13085:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 2
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	MACMU|Ensembl=ENSMMUG00000010122|UniProtKB=F7HF84	Casein kinase I isoform epsilon	ISS	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00006	Apoptosis signaling pathway	P00269	MAPK	ORYSJ|EnsemblGenome=OS02G0148100|UniProtKB=Q6Z437	Mitogen-activated protein kinase 3	ISS	10851062	PubMed	PTHR24055:SF216	SUBFAMILY NOT NAMED
P00049	Parkinson disease	P01211	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	MACMU|Ensembl=ENSMMUG00000009054|UniProtKB=F7F735	Uncharacterized protein	ISS	20112749	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00009	Axon guidance mediated by netrin	P00366	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12960248	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00047	PDGF signaling pathway	P01163	c-Jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00059	p53 pathway	P04629	PCAF	PANTR|Ensembl=ENSPTRG00000014685|UniProtKB=H2QM64	Uncharacterized protein	ISS	12724314	PubMed	PTHR22880:SF116	HISTONE ACETYLTRANSFERASE KAT2B
P00021	FGF signaling pathway	P00641	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	PANTR|Ensembl=ENSPTRG00000018827|UniProtKB=H2RD22	Uncharacterized protein	ISS	11988536	PubMed	PTHR10126:SF20	TATA-BOX-BINDING PROTEIN
P00006	Apoptosis signaling pathway	P00302	ATF	PANTR|Ensembl=ENSPTRG00000034357|UniProtKB=H2RCD1	Uncharacterized protein	ISS	11390664	PubMed	PTHR22952:SF168	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-6 BETA
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00005	Angiogenesis	P00222	VEGFR-2	BOVIN|Ensembl=ENSBTAG00000000782|UniProtKB=F1MWF1	Uncharacterized protein	ISS	11221852	PubMed	PTHR24416:SF45	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00833	RGS	MOUSE|MGI=MGI=1927469|UniProtKB=Q9QZB0	Regulator of G-protein signaling 17	IDA	21240406	PubMed	PTHR10845:SF196	REGULATOR OF G-PROTEIN SIGNALING 17
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	DANRE|ZFIN=ZDB-GENE-020125-3|UniProtKB=E7F1V8	Uncharacterized protein	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00021	FGF signaling pathway	P00629	PP2A	MOUSE|MGI=MGI=2442660|UniProtKB=Q8BG02	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform	ISS	7918404	PubMed	PTHR11871:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B GAMMA ISOFORM
P00010	B cell activation	P00381	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00025	Hedgehog signaling pathway	P00682	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00780	Microtubule	TRIVA|Gene=TVAG_008680|UniProtKB=A2DC16	Beta-tubulin, putative	IDA	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CHICK|Ensembl=ENSGALG00000009405|UniProtKB=F1NKF1	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00021	FGF signaling pathway	P00637	MKK4,7	MOUSE|MGI=MGI=1346869|UniProtKB=P47809	Dual specificity mitogen-activated protein kinase kinase 4	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00005	Angiogenesis	P00189	Fzd	RAT|RGD=631406|UniProtKB=Q8CHL0	Frizzled-5	ISS	11212302	PubMed	PTHR11309:SF126	FRIZZLED-5
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00629	PP2A	MACMU|Ensembl=ENSMMUG00000020819|UniProtKB=F7HSM1	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P04629	PCAF	CANLF|Ensembl=ENSCAFG00000005810|UniProtKB=F1PN31	Uncharacterized protein	ISS			PTHR22880:SF116	HISTONE ACETYLTRANSFERASE KAT2B
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04398	p53 pathway feedback loops 2	P04649	Myc	DANRE|ZFIN=ZDB-GENE-990415-162|UniProtKB=P52160	Transcriptional regulator Myc-A	TAS	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00005	Angiogenesis	P00200	Dsh	CAEEL|WormBase=WBGene00001102|UniProtKB=Q18239	DiSHevelled related	ISS			PTHR10878:SF25	SEGMENT POLARITY PROTEIN DISHEVELLED
P00020	FAS signaling pathway	P00615	JNK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00057	Wnt signaling pathway	P01439	C-terminal Binding Protein	ORNAN|Ensembl=ENSOANG00000000244|UniProtKB=F6YV22	Uncharacterized protein	ISS	10375506	PubMed	PTHR10996:SF128	C-TERMINAL-BINDING PROTEIN 1
P00011	Blood coagulation	P00406	Fibrinogen	BOVIN|Gene=FGG|UniProtKB=P12799	Fibrinogen gamma-B chain	ISS	89366676	PubMed	PTHR19143:SF338	FIBRINOGEN GAMMA CHAIN
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05731	GABA-B receptor II signaling	P05753	Ca channel	MOUSE|MGI=MGI=88296|UniProtKB=O55017	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	11976940	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CAEEL|WormBase=WBGene00000366|UniProtKB=P34545	Protein cbp-1	TAS	10664585	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00030	Hypoxia response via HIF activation	P00823	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=2141917|UniProtKB=Q8BZ03	Serine/threonine-protein kinase D2	ISS	11062248	PubMed	PTHR22968:SF12	SERINE/THREONINE-PROTEIN KINASE D2
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MOUSE|MGI=MGI=1346875|UniProtKB=O08648	Mitogen-activated protein kinase kinase kinase 4	IGI	11730323	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01080	AChE	BRAFL|Gene=BRAFLDRAFT_132597|UniProtKB=C3ZRW7	Carboxylic ester hydrolase	ISS	87080761	PubMed	PTHR11559:SF356	ACETYLCHOLINESTERASE
P00019	Endothelin signaling pathway	P00591	PLCbeta	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IGI	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05915	Opioid proenkephalin pathway	P05995	proenkephalin	XENTR|Xenbase=XB-GENE-942760|UniProtKB=F6Y5F6	Uncharacterized protein	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00036	Interleukin signaling pathway	P00966	mTOR	CANLF|Ensembl=ENSCAFG00000016648|UniProtKB=E2R2L2	Uncharacterized protein	ISS	14526383	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04393	Ras Pathway	P04558	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	IDA	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00046	Oxidative stress response	P01138	MKK4	RAT|RGD=1311192|UniProtKB=A0A0G2K3R1	Protein Map3k4	ISS	602425	OMIM	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00023	General transcription regulation	P00663	TFIIFalpha	DROME|FlyBase=FBgn0010282|UniProtKB=Q05913	General transcription factor IIF subunit 1	ISS			PTHR13011:SF0	GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	DANRE|ZFIN=ZDB-GENE-020503-1|UniProtKB=Q1LWJ4	Tyrosine-protein kinase receptor	ISS	11182407	gi	PTHR24416:SF498	TYROSINE-PROTEIN KINASE RECEPTOR
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01076	CAT	HUMAN|HGNC=1912|UniProtKB=P28329	Choline O-acetyltransferase	ISS	92155737	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P00047	PDGF signaling pathway	P01153	GSK3	PANTR|Ensembl=ENSPTRG00000011049|UniProtKB=H2QGF9	Glycogen synthase kinase 3 alpha	ISS	12086949	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00006	Apoptosis signaling pathway	P00321	HSP70	EMENI|EnsemblGenome=CADANIAG00008731|UniProtKB=Q5BBL8	GR78_NEUCR 78 kDa GLUCOSE-REGULATED PROTEIN HOMOLOG (GRP 78) (IMMUNOGLOBULIN HEAVY CHAIN BINDING PROTEIN HOMOLOG) (BIP)	ISS	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00010	B cell activation	P00391	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02771	Pyrimidine Metabolism	P03126	Nucleoside Phosphorylase	ECOLI|EcoGene=EG10219|UniProtKB=P07650	Thymidine phosphorylase	ISS	9278503	PubMed	PTHR10515:SF0	THYMIDINE PHOSPHORYLASE
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00029	Huntington disease	P00780	Microtubule	CHICK|Ensembl=ENSGALG00000012821|UniProtKB=P32882	Tubulin beta-2 chain	IDA	12932731	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00059	p53 pathway	P01485	p53	PANTR|Ensembl=ENSPTRG00000008703|UniProtKB=H2QC53	Cellular tumor antigen p53	ISS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00059	p53 pathway	P04609	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	ISS	9620264	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00012	Cadherin signaling pathway	P00470	F-actin	CHICK|Ensembl=ENSGALG00000014620|UniProtKB=F1N8P3	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00302	ATF	PANTR|Ensembl=ENSPTRG00000012660|UniProtKB=H2QJ07	Activating transcription factor 2	ISS	9819389	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95809|UniProtKB=P23819	Glutamate receptor 2	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MOUSE|MGI=MGI=109165|UniProtKB=Q61012	Guanine nucleotide-binding protein G(T) subunit gamma-T1	ISS	3100519	PubMed	PTHR13809:SF26	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT GAMMA-T1
P04393	Ras Pathway	P04547	Ras	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	IDA	12104050	PubMed	PTHR24070:SF189	GTPASE NRAS
P04393	Ras Pathway	P04556	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01419	Ets	RAT|RGD=2583|UniProtKB=P41156	Protein C-ets-1	ISS	15298723	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00012	Cadherin signaling pathway	P00470	F-actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g242065|UniProtKB=A7S0V7	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04393	Ras Pathway	P04546	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00010	B cell activation	P00386	Calcineurin	RAT|RGD=3383|UniProtKB=P20651	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	IDA	12091710	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00391	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	ISS	8170357	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	RAT|RGD=2736|UniProtKB=P35439	Glutamate receptor ionotropic, NMDA 1	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00012	Cadherin signaling pathway	P00473	P120	BOVIN|Ensembl=ENSBTAG00000002411|UniProtKB=E1BQ11	Uncharacterized protein	ISS			PTHR10372:SF6	CATENIN DELTA-1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	TAKRU|Ensembl=ENSTRUG00000002863|UniProtKB=H2S2N9	Uncharacterized protein	ISS	1638632	PubMed	PTHR18914:SF29	CATENIN ALPHA-2
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00006	Apoptosis signaling pathway	P00257	Bcl-xL	BOVIN|Ensembl=ENSBTAG00000006526|UniProtKB=Q05KJ0	BCL2-like 1	ISS	7828536	PubMed	PTHR11256:SF12	BCL-2-LIKE PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	BOVIN|Gene=MYH2|UniProtKB=Q9BE41	Myosin-2	ISS	89264452	PubMed	PTHR13140:SF385	MYOSIN-2
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CHICK|Ensembl=ENSGALG00000005410|UniProtKB=Q9YGX6	Protein Wnt	TAS	11266476	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12874273	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	HUMAN|HGNC=4572|UniProtKB=P42262	Glutamate receptor 2	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MOUSE|MGI=MGI=1858210|UniProtKB=O70439	Syntaxin-7	ISS	14570579	PubMed	PTHR19957:SF90	SYNTAXIN-7
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00019	Endothelin signaling pathway	P00570	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01177	P110ACT	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00983	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IC	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01143	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	93028473	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BOVIN|Ensembl=ENSBTAG00000014291|UniProtKB=A6H6X8	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00034	Integrin signalling pathway	P00916	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00010	B cell activation	P00384	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04393	Ras Pathway	P04546	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00059	p53 pathway	P04627	E2F-1	DROME|FlyBase=FBgn0011766|UniProtKB=Q27368	Transcription factor E2f1	ISS	20196006	PubMed	PTHR12081:SF52	TRANSCRIPTION FACTOR E2F2-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05731	GABA-B receptor II signaling	P05755	Gbeta	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	RCA	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	PANTR|Ensembl=ENSPTRG00000006216|UniProtKB=H2Q832	Adenylate cyclase 4	ISS	2491850	PubMed	PTHR11920:SF286	ADENYLATE CYCLASE TYPE 4
P00006	Apoptosis signaling pathway	P00272	ASK1	HUMAN|HGNC=6857|UniProtKB=Q99683	Mitogen-activated protein kinase kinase kinase 5	IDA	8974401	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00056	VEGF signaling pathway	P01413	PI3K	CAEEL|WormBase=WBGene00006932|UniProtKB=Q9TXI7	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	11927551	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00019	Endothelin signaling pathway	P00590	IP3 R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	PANTR|Ensembl=ENSPTRG00000034469|UniProtKB=H2Q2V0	Uncharacterized protein	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	HUMAN|HGNC=129|UniProtKB=P68133	Actin, alpha skeletal muscle	IC	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	IC	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00948	Rho	BOVIN|Ensembl=ENSBTAG00000014299|UniProtKB=Q1RMJ6	Rho-related GTP-binding protein RhoC	ISS	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00005	Angiogenesis	P00238	Ras	XENTR|Xenbase=XB-GENE-494548|UniProtKB=F7EC26	Uncharacterized protein	ISS	20362513	PubMed	PTHR24070:SF186	GTPASE KRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	HUMAN|HGNC=19392|UniProtKB=Q8WXH5	Suppressor of cytokine signaling 4	TAS	10500304	PubMed	PTHR44282:SF2	SUPPRESSOR OF CYTOKINE SIGNALING 4
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000018202|UniProtKB=E2RPJ2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00047	PDGF signaling pathway	P01162	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	DANRE|ZFIN=ZDB-GENE-000502-1|UniProtKB=Q1RLX1	Receptor protein serine/threonine kinase	IDA			PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04547	Ras	CHICK|Ensembl=ENSGALG00000006885|UniProtKB=P08642	GTPase HRas	ISS	3035212	PubMed	PTHR24070:SF385	GTPASE HRAS
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	CANLF|Ensembl=ENSCAFG00000019435|UniProtKB=E2QX25	Uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF157	CASEIN KINASE I ISOFORM GAMMA-2
P02781	Threonine biosynthesis	P03191	Homoserine kinase	AQUAE|EnsemblGenome=aq_1309|UniProtKB=O67332	Homoserine kinase	ISS			PTHR20861:SF1	HOMOSERINE KINASE
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	CHICK|Gene=FZD7|UniProtKB=O57329	Frizzled-7	TAS	8717036	PubMed	PTHR11309:SF31	FRIZZLED-7
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_79607|UniProtKB=C3ZHN4	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00020	FAS signaling pathway	P00611	Gelsolin	MACMU|Ensembl=ENSMMUG00000002675|UniProtKB=F7HQ21	Macrophage-capping protein	ISS	9323209	PubMed	PTHR11977:SF13	MACROPHAGE-CAPPING PROTEIN
P00012	Cadherin signaling pathway	P00466	EGFR	PANTR|Ensembl=ENSPTRG00000009100|UniProtKB=H2QCV1	Receptor protein-tyrosine kinase	ISS	2575867	gi	PTHR24416:SF137	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2
P00049	Parkinson disease	P01230	Src kinase	MOUSE|MGI=MGI=99147|UniProtKB=Q04736	Tyrosine-protein kinase Yes	IDA	11078745	PubMed	PTHR24418:SF90	TYROSINE-PROTEIN KINASE YES
P05915	Opioid proenkephalin pathway	P05994	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	RAT|RGD=2025|UniProtKB=P68136	Actin, alpha skeletal muscle	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	MACMU|Ensembl=ENSMMUG00000017431|UniProtKB=F7HPP3	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ORYSJ|EnsemblGenome=OS03G0718100|UniProtKB=Q10DV7	Actin-1	ISS	10974003	PubMed	PTHR11937:SF364	ACTIN-11
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	HUMAN|HGNC=4046|UniProtKB=Q9H461	Frizzled-8	TAS	8717036	PubMed	PTHR11309:SF90	FRIZZLED-8
P04393	Ras Pathway	P04567	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=97441|UniProtKB=P42866	Mu-type opioid receptor	IDA	12093103	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00056	VEGF signaling pathway	P01409	cPLA2	PANTR|Ensembl=ENSPTRG00000001787|UniProtKB=H2Q0T0	Phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00010	B cell activation	P00385	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00053	T cell activation	P01304	Csk	MOUSE|MGI=MGI=88537|UniProtKB=P41241	Tyrosine-protein kinase CSK	IDA	11078745	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P02749	Leucine biosynthesis	P03000	Branched chain amino acid aminotransferase	PSEAE|EnsemblGenome=PA5013|UniProtKB=O86428	Branched-chain-amino-acid aminotransferase	ISS			PTHR42743:SF3	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE-LIKE PROTEIN 1-RELATED
P04393	Ras Pathway	P04578	Rho	PANTR|Ensembl=ENSPTRG00000040414|UniProtKB=H2RH27	Ras homolog gene family, member B	ISS	13679859	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00004	Alzheimer disease-presenilin pathway	P00172	BACE-1	MACMU|Ensembl=ENSMMUG00000007785|UniProtKB=F7CQI1	Beta-secretase 1 isoform A preproprotein	ISS	10956649	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00018	EGF receptor signaling pathway	P00542	EGFR	MONDO|Ensembl=ENSMODG00000015755|UniProtKB=F6ZSZ9	Uncharacterized protein (Fragment)	ISS	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00011	Blood coagulation	P00419	FXIIIa	MOUSE|MGI=MGI=88379|UniProtKB=Q07968	Coagulation factor XIII B chain	ISS	13624321	gi	PTHR19325:SF314	COAGULATION FACTOR XIII B CHAIN
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	RAT|RGD=61862|UniProtKB=P19491	Glutamate receptor 2	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00034	Integrin signalling pathway	P00936	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	IC	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00012	Cadherin signaling pathway	P00474	Wnt	PANTR|Ensembl=ENSPTRG00000019617|UniProtKB=Q2QLE7	Protein Wnt-2	ISS	11266476	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00034	Integrin signalling pathway	P00916	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	MONDO|Ensembl=ENSMODG00000005255|UniProtKB=F7G800	Uncharacterized protein	ISS	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00018	EGF receptor signaling pathway	P00554	Shc	RAT|RGD=69348|UniProtKB=O70143	SHC-transforming protein 3	ISS	9507002	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P00053	T cell activation	P01311	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CANLF|Ensembl=ENSCAFG00000005460|UniProtKB=F1PN73	Uncharacterized protein	ISS	15155845	PubMed	PTHR18945:SF75	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-3
P00053	T cell activation	P01305	Calmodulin	CANLF|Ensembl=ENSCAFG00000017516|UniProtKB=E2REK6	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF311	CALMODULIN
P00034	Integrin signalling pathway	P00941	Integrin alpha	MACMU|Ensembl=ENSMMUG00000000300|UniProtKB=F6Z0X3	Uncharacterized protein	ISS	3487386	PubMed	PTHR23220:SF78	INTEGRIN ALPHA-4
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P02754	Methylcitrate cycle	P03028	Aconitase	CANLF|Ensembl=ENSCAFG00000001766|UniProtKB=E2RCI0	Uncharacterized protein	ISS			PTHR11670:SF31	IRON-RESPONSIVE ELEMENT-BINDING PROTEIN 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	10755300	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00005	Angiogenesis	P00255	Notch	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CAEBR|Gene=CBG05858|UniProtKB=A8X1H0	Protein CBR-EGL-19 (Fragment)	ISS	11956331	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000018202|UniProtKB=E2RPJ2	Mitogen-activated protein kinase	ISS	12912994	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00463	betacatenin	MONDO|Ensembl=ENSMODG00000011192|UniProtKB=F6SRK5	Uncharacterized protein	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P02738	De novo purine biosynthesis	P02907	dADP kinase	DANRE|ZFIN=ZDB-GENE-000210-35|UniProtKB=F1QQX1	Nucleoside diphosphate kinase	ISS			PTHR43109:SF2	NUCLEOSIDE DIPHOSPHATE KINASE 7
P00054	Toll receptor signaling pathway	P01368	MKK2	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00050	Plasminogen activating cascade	P01244	PAI-2	MOUSE|MGI=MGI=97609|UniProtKB=P12388	Plasminogen activator inhibitor 2, macrophage	ISS	6755098	gi	PTHR11461:SF61	PLASMINOGEN ACTIVATOR INHIBITOR 2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00037	Ionotropic glutamate receptor pathway	P00998	stargazin	MOUSE|MGI=MGI=2157946|UniProtKB=Q8VHW4	Voltage-dependent calcium channel gamma-5 subunit	ISS	11140673	PubMed	PTHR12107:SF4	VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-5 SUBUNIT
P00018	EGF receptor signaling pathway	P00552	Ras	BOVIN|Ensembl=ENSBTAG00000009778|UniProtKB=E1BMX0	Uncharacterized protein	ISS	99084794	PubMed	PTHR24070:SF186	GTPASE KRAS
P00009	Axon guidance mediated by netrin	P00359	NFAT	MACMU|Ensembl=ENSMMUG00000012657|UniProtKB=F7E7J1	Uncharacterized protein	ISS	12787506	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00049	Parkinson disease	P01219	SAPK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00561	STAT	RAT|RGD=3774|UniProtKB=P52632	Signal transducer and activator of transcription 5B	IGI	8584036	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000001056|UniProtKB=H2PZL0	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	BOVIN|Ensembl=ENSBTAG00000011579|UniProtKB=F1N5C5	Muscarinic acetylcholine receptor	ISS	8100450	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	MACMU|Ensembl=ENSMMUG00000020531|UniProtKB=F7D8G7	Uncharacterized protein	ISS	15032587	PubMed	PTHR45052:SF1	SUPPRESSOR OF CYTOKINE SIGNALING 7
P00005	Angiogenesis	P00211	GSK3beta	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02742	Tetrahydrofolate biosynthesis	P02951	GTP cyclohydrolase	PLAF7|EnsemblGenome=PFL1155w|UniProtKB=Q8I5H7	GTP cyclohydrolase I	ISS			PTHR11109:SF0	GTP CYCLOHYDROLASE 1
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00012	Cadherin signaling pathway	P00474	Wnt	CANLF|Ensembl=ENSCAFG00000008760|UniProtKB=E2RTG8	Protein Wnt	ISS	14644163	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	CANLF|Ensembl=ENSCAFG00000013778|UniProtKB=F6UQ33	Phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00010	B cell activation	P00384	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_125401|UniProtKB=C3ZTX6	Putative uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	HUMAN|HGNC=7572|UniProtKB=Q9UKX2	Myosin-2	IEP	10938134	PubMed	PTHR13140:SF385	MYOSIN-2
P00018	EGF receptor signaling pathway	P00564	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MACMU|Ensembl=ENSMMUG00000022808|UniProtKB=F6UWC3	Actin-related protein 2/3 complex subunit 2	ISS	10940259	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00049	Parkinson disease	P01238	14-3-3	MOUSE|MGI=MGI=894689|UniProtKB=P62259	14-3-3 protein epsilon	ISS	98119747	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00046	Oxidative stress response	P01131	MKP5	MACMU|Ensembl=ENSMMUG00000002975|UniProtKB=F7GXT5	Dual specificity protein phosphatase 14	ISS			PTHR10159:SF338	DUAL SPECIFICITY PROTEIN PHOSPHATASE 14
P00048	PI3 kinase pathway	P01179	PKB	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	TAS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	RAT|RGD=2917|UniProtKB=P15127	Insulin receptor	ISS	11182407	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	TAKRU|Ensembl=ENSTRUG00000006307|UniProtKB=H2SSM1	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	G01511	SPRY	MOUSE|MGI=MGI=1345144|UniProtKB=Q9WTP2	Protein sprouty homolog 4	ISS	12027893	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00973	PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02733	Carnitine metabolism	P02866	Carnitine dehydratase	ECOLI|EcoGene=EG13284|UniProtKB=P76518	Acetyl-CoA:oxalate CoA-transferase	ISS			PTHR43949:SF1	ACETYL-COA:OXALATE COA-TRANSFERASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	NEUCR|EnsemblGenome=EFNCRG00000004240|UniProtKB=Q01386	cAMP-dependent protein kinase regulatory subunit	IC	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	PANTR|Ensembl=ENSPTRG00000015968|UniProtKB=H2R2Q6	Uncharacterized protein	ISS	8406481	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04397	p53 pathway by glucose deprivation	G04706	TSC2	BOVIN|Ensembl=ENSBTAG00000020617|UniProtKB=E1BNT2	Uncharacterized protein	ISS	12150915	PubMed	PTHR10063:SF0	TUBERIN
P00018	EGF receptor signaling pathway	P00562	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	IPI	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00570	PKA	LEIMA|EnsemblGenome=LmjF.35.4010|UniProtKB=Q9GNR4	Protein kinase A catalytic subunit isoform 1	ISS	10218114	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04557	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00054	Toll receptor signaling pathway	P01369	MKK1	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00047	PDGF signaling pathway	P01151	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000002349|UniProtKB=P61267	Syntaxin-1B	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P05918	p38 MAPK pathway	P06020	p38delta	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00018	EGF receptor signaling pathway	P00561	STAT	MONDO|Ensembl=ENSMODG00000028212|UniProtKB=F7BYN4	Signal transducer and activator of transcription	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00013	Cell cycle	P00480	Proteasome	CHICK|Ensembl=ENSGALG00000011128|UniProtKB=E1C6N0	Uncharacterized protein	ISS	9727008	PubMed	PTHR10410:SF5	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 14
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	MOUSE|MGI=MGI=96575|UniProtKB=P15208	Insulin receptor	TAS	11182407	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IDA	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00046	Oxidative stress response	P01129	JNK1/2	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00058	mRNA splicing	P01478	U2	RAT|RGD=1310194|UniProtKB=B5DEQ4	Protein Snrpb2	ISS			PTHR10501:SF21	U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B''
P04397	p53 pathway by glucose deprivation	P04641	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	IC	11554549	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	HUMAN|HGNC=10000|UniProtKB=P49798	Regulator of G-protein signaling 4	ISS	8756726	PubMed	PTHR10845:SF184	REGULATOR OF G-PROTEIN SIGNALING 4
P00029	Huntington disease	P00777	CBP	CAEEL|WormBase=WBGene00010545|UniProtKB=G5EBG3	CBP/p300 homolog	IDA	10823891	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00057	Wnt signaling pathway	P01440	Cadherin	BOVIN|Gene=PCDH18|UniProtKB=A7MB46	Protocadherin-18	ISS	8120095	PubMed	PTHR24028:SF9	PROTOCADHERIN-18
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	MACMU|Ensembl=ENSMMUG00000001661|UniProtKB=F7GR69	Uncharacterized protein	ISS	11554554	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04393	Ras Pathway	P04567	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00018	EGF receptor signaling pathway	P00551	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IGI	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	RAT|RGD=628852|UniProtKB=Q02294	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	15079861	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00030	Hypoxia response via HIF activation	P00819	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00990	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02787	Vitamin B6 metabolism	P03229	Pyridoxal reductase	SCHPO|PomBase=SPAC9E9.11|UniProtKB=O14295	Pyridoxal reductase	IEA	9501991	PubMed	PTHR43625:SF14	PYRIDOXAL REDUCTASE-RELATED
P00021	FGF signaling pathway	P00624	14-3-3	CANLF|Ensembl=ENSCAFG00000000580|UniProtKB=F1PBL1	Uncharacterized protein	ISS	12615066	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	RAT|RGD=621705|UniProtKB=Q8VHN2	Glutamate receptor ionotropic, NMDA 3B	ISS	14698601	PubMed	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	PANTR|Ensembl=ENSPTRG00000006865|UniProtKB=H2Q930	Uncharacterized protein	ISS	11404397	PubMed	PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CAEBR|Gene=CBG23090|UniProtKB=A8Y4R0	Protein CBG23090	ISS	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	PANTR|Ensembl=ENSPTRG00000009871|UniProtKB=H2QE95	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00011	Blood coagulation	P00418	Fibrin monomer	PANTR|Ensembl=ENSPTRG00000016535|UniProtKB=H2QQB5	Uncharacterized protein	ISS	4503689	gi	PTHR19143:SF232	FIBRINOGEN ALPHA CHAIN
P04398	p53 pathway feedback loops 2	P04668	p53	CANLF|Gene=TP53|UniProtKB=Q29537	Cellular tumor antigen p53	TAS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	TAKRU|Ensembl=ENSTRUG00000010005|UniProtKB=H2TKG8	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT4G01370|UniProtKB=Q39024	Mitogen-activated protein kinase 4	ISS	12787066	PubMed	PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00047	PDGF signaling pathway	P01168	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	ISS	7565716	PubMed	PTHR10048:SF14	PI-3 KINASE
P02747	Histidine biosynthesis	P02991	Histidinephosphate aminotransferase	SCHPO|PomBase=SPBC11B10.02c|UniProtKB=P36605	Histidinol-phosphate aminotransferase	ISS			PTHR42885:SF2	HISTIDINOL-PHOSPHATE AMINOTRANSFERASE
P04397	p53 pathway by glucose deprivation	P04641	Akt	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	ISS	14526383	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00566	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04570	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00036	Interleukin signaling pathway	P00990	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00021	FGF signaling pathway	P00638	PLCgamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	IDA	6319455	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00001	Adrenaline and noradrenaline biosynthesis	P00062	TH	RAT|RGD=3853|UniProtKB=P04177	Tyrosine 3-monooxygenase	ISS	12480184	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00036	Interleukin signaling pathway	P00989	Ets	RAT|RGD=1359607|UniProtKB=Q6BDS1	Transcription factor PU.1	ISS	8970723	PubMed	PTHR11849:SF16	TRANSCRIPTION FACTOR PU.1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00866	Cytokine receptor	BOVIN|Ensembl=ENSBTAG00000021819|UniProtKB=Q04790	Interferon alpha/beta receptor 1	IDA	12163451	PubMed	PTHR20859:SF54	INTERFERON ALPHA/BETA RECEPTOR 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MACMU|Ensembl=ENSMMUG00000001761|UniProtKB=F7GLJ7	Uncharacterized protein	ISS			PTHR13140:SF277	UNCONVENTIONAL MYOSIN-IB
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IDA	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00006	Apoptosis signaling pathway	P00274	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=2652894|UniProtKB=Q80Y86	Mitogen-activated protein kinase 15	ISS	12787066	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00029	Huntington disease	P00775	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	MACMU|Ensembl=ENSMMUG00000010184|UniProtKB=F6SR09	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	RCA			PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	HUMAN|HGNC=7881|UniProtKB=P46531	Neurogenic locus notch homolog protein 1	IDA	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	CHICK|Ensembl=ENSGALG00000010273|UniProtKB=P48463	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	2461222	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	BOVIN|Ensembl=ENSBTAG00000013790|UniProtKB=E1B847	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DICDI|dictyBase=DDB_G0279413|UniProtKB=P05987	cAMP-dependent protein kinase regulatory subunit	IC	2372396	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01173	STAT	MACMU|Ensembl=ENSMMUG00000010705|UniProtKB=F7G8V4	Signal transducer and activator of transcription	ISS	95236292	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00047	PDGF signaling pathway	P01154	Ras	PANTR|Ensembl=ENSPTRG00000034469|UniProtKB=H2Q2V0	Uncharacterized protein	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P06215	MYO signaling pathway	P06310	BABO	DROME|FlyBase=FBgn0011300|UniProtKB=A1Z7L8	Receptor protein serine/threonine kinase	IEA	http://flybase.org/reports/FBgn0011300.html	Website	PTHR23255:SF71	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00052	TGF-beta signaling pathway	P01275	P38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	HUMAN|HGNC=2509|UniProtKB=P35221	Catenin alpha-1	TAS	1768802	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00059	p53 pathway	G01579	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P02786	Vitamin B6 biosynthesis	P03225	1-Deoxyxylulose-5-phosphate synthase	FUSNN|EnsemblGenome=FN1464|UniProtKB=Q8R606	1-deoxy-D-xylulose-5-phosphate synthase	ISS			PTHR43322:SF1	SUBFAMILY NOT NAMED
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04393	Ras Pathway	P04553	PAK	MACMU|Ensembl=ENSMMUG00000012033|UniProtKB=F7GWI2	Serine/threonine-protein kinase PAK 2	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00036	Interleukin signaling pathway	P00964	p90RSK	MOUSE|MGI=MGI=104558|UniProtKB=P18653	Ribosomal protein S6 kinase alpha-1	IGI	6755374	gi	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	CANLF|Ensembl=ENSCAFG00000018144|UniProtKB=F1PNI3	Uncharacterized protein	ISS	74094688	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00629	PP2A	HUMAN|HGNC=9311|UniProtKB=Q13362	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	ISS	8576224	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P00010	B cell activation	P00398	IP3R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00005	Angiogenesis	P00203	Erk	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00056	VEGF signaling pathway	P01425	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04393	Ras Pathway	P04541	p90RSK	HUMAN|HGNC=10435|UniProtKB=Q9UK32	Ribosomal protein S6 kinase alpha-6	IDA	15632195	PubMed	PTHR24351:SF98	RIBOSOMAL PROTEIN S6 KINASE ALPHA-6
P00048	PI3 kinase pathway	P01199	Galpha	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00050	Plasminogen activating cascade	P01243	uPA	MACMU|Ensembl=ENSMMUG00000009906|UniProtKB=F6YDX7	Uncharacterized protein	ISS	137114	gi	PTHR24264:SF38	UROKINASE-TYPE PLASMINOGEN ACTIVATOR
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=88356|UniProtKB=P10287	Cadherin-3	IDA	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P06959	CCKR signaling map	P07059	BCL2	HUMAN|HGNC=990|UniProtKB=P10415	Apoptosis regulator Bcl-2	RCA	17936584	PubMed	PTHR11256:SF11	APOPTOSIS REGULATOR BCL-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IDA	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04398	p53 pathway feedback loops 2	P04651	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P04393	Ras Pathway	P04546	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P02728	Arginine biosynthesis	P02840	Argininosuccinate synthase	BACSU|EnsemblGenome=BSU29450|UniProtKB=O34347	Argininosuccinate synthase	ISS			PTHR11587:SF2	ARGININOSUCCINATE SYNTHASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00219	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00046	Oxidative stress response	P01128	MEF-2	CANLF|Ensembl=ENSCAFG00000008302|UniProtKB=F1PAY8	Uncharacterized protein	ISS	11274345	PubMed	PTHR11945:SF25	MYOCYTE-SPECIFIC ENHANCER FACTOR 2C
P04395	Vasopressin synthesis	P04590	Vasopressin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04393	Ras Pathway	P04546	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IDA	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	P00565	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	CAEEL|WormBase=WBGene00003822|UniProtKB=Q21029	Mitogen-activated protein kinase kinase kinase nsy-1	ISS			PTHR11584:SF369	APOPTOTIC SIGNAL-REGULATING KINASE 1, ISOFORM C
P00048	PI3 kinase pathway	P01178	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00005	Angiogenesis	P00252	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12186904	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00896	Insulin IGF	BOVIN|Ensembl=ENSBTAG00000013066|UniProtKB=P07456	Insulin-like growth factor II	ISS	4504609	gi	PTHR11454:SF10	INSULIN-LIKE GROWTH FACTOR II
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IGI	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00562	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	ISS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000022550|UniProtKB=F6Y9I6	Serine/threonine-protein kinase	ISS	12393506	PubMed	PTHR22968:SF9	SERINE/THREONINE-PROTEIN KINASE D1
P05915	Opioid proenkephalin pathway	P05987	peptide F	DANRE|ZFIN=ZDB-GENE-030729-31|UniProtKB=A8E7S2	Uncharacterized protein	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	CHLTR|EnsemblGenome=CT_827|UniProtKB=O84834	Ribonucleoside-diphosphate reductase subunit alpha	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MACMU|Ensembl=ENSMMUG00000014762|UniProtKB=F7G0R4	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF344	MYOSIN-7
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00006	Apoptosis signaling pathway	P00269	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12701063	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	MACMU|Ensembl=ENSMMUG00000002595|UniProtKB=F7HQD8	Uncharacterized protein	ISS	10778855	PubMed	PTHR44557:SF1	COLLAGEN ALPHA-1 XIV  CHAIN
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	MACMU|Ensembl=ENSMMUG00000022884|UniProtKB=F7CAM5	Glutamine synthetase	ISS			PTHR20852:SF45	GLUTAMINE SYNTHETASE
P00057	Wnt signaling pathway	P01457	GBeta	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04398	p53 pathway feedback loops 2	P04661	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00036	Interleukin signaling pathway	P00990	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01433	SIAH-1	XENTR|Xenbase=XB-GENE-1004950|UniProtKB=A4IIN1	E3 ubiquitin-protein ligase	ISS			PTHR10315:SF11	E3 UBIQUITIN-PROTEIN LIGASE SIAH2
P04393	Ras Pathway	P04567	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	IDA	11292874	PubMed	PTHR10048:SF14	PI-3 KINASE
P04393	Ras Pathway	P04552	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	TAKRU|Ensembl=ENSTRUG00000011297|UniProtKB=H2TV18	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00034	Integrin signalling pathway	P00907	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00564	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P05915	Opioid proenkephalin pathway	P05994	G-protein	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	IC	89107990	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	ISS	14698601	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00030	Hypoxia response via HIF activation	P00825	Thioredoxin	ANOGA|EnsemblGenome=AGAP009584|UniProtKB=Q9NGZ1	Thioredoxin	ISS	12115731	PubMed	PTHR10438:SF359	THIOREDOXIN
P00021	FGF signaling pathway	P00627	ERK1-2	ARATH|TAIR=AT4G01370|UniProtKB=Q39024	Mitogen-activated protein kinase 4	IGI			PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=88399|UniProtKB=P32211	Muscarinic acetylcholine receptor M4	IDA	91373358	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P06664	Gonadotropin-releasing hormone receptor pathway	P06812	L-type Ca2+	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	RCA	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00182	p38MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00036	Interleukin signaling pathway	P00973	PKB	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04393	Ras Pathway	P04553	PAK	CANLF|Ensembl=ENSCAFG00000004956|UniProtKB=E2REH3	Uncharacterized protein	ISS	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00019	Endothelin signaling pathway	P00566	ERK	ARATH|TAIR=AT3G45640|UniProtKB=Q39023	Mitogen-activated protein kinase 3	ISS			PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02738	De novo purine biosynthesis	P02891	GDP kinase	HUMAN|HGNC=7850|UniProtKB=P22392	Nucleoside diphosphate kinase B	ISS			PTHR11349:SF57	NUCLEOSIDE DIPHOSPHATE KINASE B
P00029	Huntington disease	P00777	CBP	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00020	FAS signaling pathway	P00594	Caspase8	PANTR|Ensembl=ENSPTRG00000012801|UniProtKB=H2QJ86	Caspase 8, apoptosis-related cysteine peptidase	ISS	11788820	PubMed	PTHR10454:SF162	CASPASE-8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	IDA	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01472	Histone deacetylase	HUMAN|HGNC=4853|UniProtKB=Q92769	Histone deacetylase 2	IDA	10485845	PubMed	PTHR10625:SF171	HISTONE DEACETYLASE 2
P00021	FGF signaling pathway	P00628	JNK1-3	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IGI	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00034	Integrin signalling pathway	P00951	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00256	PLC-gamma	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00019	Endothelin signaling pathway	P00590	IP3 R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00019	Endothelin signaling pathway	P00580	ET-RA/B	PANTR|Ensembl=ENSPTRG00000016494|UniProtKB=H2QQ94	Endothelin receptor type A	ISS	12538737	PubMed	PTHR24243:SF31	ENDOTHELIN-1 RECEPTOR
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	DANRE|ZFIN=ZDB-GENE-990415-278|UniProtKB=P43446	Protein Wnt-10a	TAS	8717036	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00054	Toll receptor signaling pathway	P01358	ERK1	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00590	IP3 R	CAEEL|WormBase=WBGene00002173|UniProtKB=Q9Y0A1	Inositol 1,4,5-trisphosphate receptor itr-1	ISS	11007872	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	CANLF|Ensembl=ENSCAFG00000001738|UniProtKB=E2RDG9	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	ISS	9166716	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IC	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-2280|UniProtKB=Q6P025	Gnb3 protein	ISS			PTHR19850:SF35	GNB3 PROTEIN
P00010	B cell activation	P00379	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	ISS	11889126	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_188187|UniProtKB=E9GJ31	Guanine nucleotide binding protein, q polypeptide	ISS	14765990	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P02738	De novo purine biosynthesis	P02909	GDP reductase	TRYB2|Gene=Tb11.v4.0004|UniProtKB=Q382Q3	Ribonucleoside-diphosphate reductase small chain	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00053	T cell activation	P01332	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=109356|UniProtKB=O09044	Synaptosomal-associated protein 23	IC	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000019846|UniProtKB=F7GUW1	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF99	CADHERIN-9
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00624	14-3-3	CANLF|Ensembl=ENSCAFG00000000580|UniProtKB=F1PBL1	Uncharacterized protein	ISS	92283271	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	HUMAN|HGNC=1401|UniProtKB=Q02641	Voltage-dependent L-type calcium channel subunit beta-1	IC	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00021	FGF signaling pathway	P00640	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=264|UniProtKB=P29275	Adenosine receptor A2b	IDA			PTHR24246:SF18	ADENOSINE RECEPTOR A2B
P00029	Huntington disease	P00774	Dynein complex	MACMU|Ensembl=ENSMMUG00000005622|UniProtKB=F7GEW1	Uncharacterized protein	ISS	9454836	PubMed	PTHR10676:SF310	DYNEIN HEAVY CHAIN 7, AXONEMAL
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	PANTR|Ensembl=ENSPTRG00000006510|UniProtKB=H2Q8K1	Presenilin	ISS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00034	Integrin signalling pathway	P00907	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02763	Peptidoglycan biosynthesis	P03090	N-Acetylglucosaminyl transferase	DEIRA|EnsemblGenome=DR_1076|UniProtKB=Q9RVF3	Cell wall synthesis protein, putative	ISS			PTHR43025:SF4	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	CAEBR|Gene=CBG14305|UniProtKB=A8XJQ6	cAMP-dependent protein kinase, catalytic subunit-like	ISS	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05934	ELK1	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	11151091	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00034	Integrin signalling pathway	P00912	Arp2/3	ORNAN|Ensembl=ENSOANG00000000999|UniProtKB=F6WN02	Actin-related protein 2/3 complex subunit 5	ISS	12473693	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	HUMAN|HGNC=232|UniProtKB=Q08828	Adenylate cyclase type 1	ISS	2491850	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	DROME|FlyBase=FBgn0260964|UniProtKB=Q8IH57	GH10249p	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00017	DNA replication	P00533	Pol delta	PLAF7|EnsemblGenome=PFC0340w|UniProtKB=O77321	DNA polymerase delta small subunit, putative	ISS	99376085	PubMed	PTHR10416:SF0	DNA POLYMERASE DELTA SUBUNIT 2
P02775	Salvage pyrimidine ribonucleotides	P03155	Cytosine deaminase	HUMAN|HGNC=21172|UniProtKB=Q7Z6V5	tRNA-specific adenosine deaminase 2	ISS			PTHR11079:SF92	TRNA-SPECIFIC ADENOSINE DEAMINASE 2
P06587	Nicotine pharmacodynamics pathway	P06593	CHRNA5	MOUSE|MGI=MGI=87889|UniProtKB=Q2MKA5	Neuronal acetylcholine receptor subunit alpha-5	ISS	85270494	PubMed	PTHR18945:SF76	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5
P00057	Wnt signaling pathway	P01458	Protein Kinase C	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	11591316	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00004	Alzheimer disease-presenilin pathway	P00149	Pen-2	CANLF|Ensembl=ENSCAFG00000032463|UniProtKB=J9P0J9	Presenilin enhancer	ISS	12110170	PubMed	PTHR16318:SF0	GAMMA-SECRETASE SUBUNIT PEN-2
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	RAT|RGD=2028|UniProtKB=P38445	Activin receptor type-2B	TAS	11252892	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00053	T cell activation	P01315	Calcineurin	PANTR|Ensembl=ENSPTRG00000016315|UniProtKB=H2QPY6	Serine/threonine-protein phosphatase	ISS	12091710	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01275	P38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00586	Gq	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	9166716	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04398	p53 pathway feedback loops 2	P04657	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	11256888	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	DROME|FlyBase=FBgn0001961|UniProtKB=O97182	Actin related complex p41 subunit	ISS	12473693	PubMed	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P02736	Coenzyme A biosynthesis	P02882	Pantothenate cysteine ligase	LEPIN|EnsemblGenome=LA_3936|UniProtKB=Q8EZB9	Flavoprotein	ISS			PTHR14359:SF6	PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04393	Ras Pathway	P04542	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00586	Gq	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05915	Opioid proenkephalin pathway	P05994	G-protein	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF31	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01465	Ggamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00047	PDGF signaling pathway	P01153	GSK3	CANLF|Ensembl=ENSCAFG00000004882|UniProtKB=F1PAE3	Uncharacterized protein	ISS	12086949	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	RAT|RGD=2735|UniProtKB=Q63273	Glutamate receptor ionotropic, kainate 5	ISS	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-030131-9966|UniProtKB=Q6TH03	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00008	Axon guidance mediated by Slit/Robo	P00355	Rho	CAEBR|Gene=CBG13664|UniProtKB=A8XIF5	Protein CBR-RHO-1	ISS	7798239	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00049	Parkinson disease	P01208	Hsp70	TRIVA|Gene=TVAG_237140|UniProtKB=A2DCR4	Mitochondrial-type HSP70, putative	IDA	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IDA	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00013	Cell cycle	P00484	Cyclin D	BOVIN|Ensembl=ENSBTAG00000016649|UniProtKB=Q0P5D3	G1/S-specific cyclin-D2	ISS	93275661	PubMed	PTHR10177:SF66	G1/S-SPECIFIC CYCLIN-D2
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P06664	Gonadotropin-releasing hormone receptor pathway	P06856	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	RCA	8479536	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	CANLF|Ensembl=ENSCAFG00000028654|UniProtKB=J9P702	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00559	MEK1-2	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IGI	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P06587	Nicotine pharmacodynamics pathway	P06602	PPP1CA	DANRE|ZFIN=ZDB-GENE-040516-3|UniProtKB=Q6NSN6	Serine/threonine-protein phosphatase	ISS	10433257	PubMed	PTHR11668:SF191	SERINE/THREONINE-PROTEIN PHOSPHATASE
P00005	Angiogenesis	P00249	PAK	CHICK|Ensembl=ENSGALG00000008058|UniProtKB=F1N8W8	Uncharacterized protein	ISS	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IGI	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00010	B cell activation	P00376	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00005	Angiogenesis	P00203	Erk	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	HUMAN|HGNC=30788|UniProtKB=Q9H808	Transducin-like enhancer protein 6	ISS	9783586	PubMed	PTHR10814:SF2	TRANSDUCIN-LIKE ENHANCER PROTEIN 6
P00018	EGF receptor signaling pathway	P00557	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	IGI	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	TAS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00036	Interleukin signaling pathway	P00983	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00790	beta-Tubulin	RAT|RGD=1305887|UniProtKB=Q4QQV0	Protein Tubb6	TAS	9454836	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00558	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DICDI|dictyBase=DDB_G0289487|UniProtKB=P07829	Actin-3	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00034	Integrin signalling pathway	P00931	Integrin beta	CANLF|Ensembl=ENSCAFG00000013735|UniProtKB=F1PPG5	Integrin beta	IDA	7949057	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00021	FGF signaling pathway	P00632	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00034	Integrin signalling pathway	P00916	Ras	DICPU|Gene=DICPUDRAFT_92731|UniProtKB=F0ZWE6	Putative uncharacterized protein rasG	ISS	7997267	PubMed	PTHR24070:SF282	RAS GTPASE-RELATED
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00047	PDGF signaling pathway	P01162	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00048	PI3 kinase pathway	P01177	P110ACT	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00709	Glycogen synthase D	PANTR|Ensembl=ENSPTRG00000004761|UniProtKB=H2Q5L0	Uncharacterized protein	ISS	4212312	PubMed	PTHR10176:SF1	GLYCOGEN  STARCH  SYNTHASE, LIVER
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	CAEEL|WormBase=WBGene00000203|UniProtKB=Q9XWV3	Probable actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00029	Huntington disease	P00780	Microtubule	SCHMA|EnsemblGenome=Smp_079970|UniProtKB=G4VTA5	Putative tubulin beta chain	ISS	12932731	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00011	Blood coagulation	P00458	GP IIIa	MACMU|Ensembl=ENSMMUG00000003289|UniProtKB=F7FG54	Integrin beta	ISS	4206165	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00034	Integrin signalling pathway	P00944	Actin	MONDO|Ensembl=ENSMODG00000012036|UniProtKB=F7ALP1	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00047	PDGF signaling pathway	P01161	Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	ISS	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CANLF|Ensembl=ENSCAFG00000012181|UniProtKB=F2Z4N7	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	YEAST|SGD=S000005854|UniProtKB=P33328	Synaptobrevin homolog 2	IC			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	BRAFL|Gene=BRAFLDRAFT_128184|UniProtKB=C4A0B6	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF402	INSULIN RECEPTOR
P04393	Ras Pathway	P04561	SRF	MONDO|Ensembl=ENSMODG00000018981|UniProtKB=F7FP88	Uncharacterized protein	ISS	15647354	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IDA	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	XENTR|Xenbase=XB-GENE-957124|UniProtKB=F7BDN8	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	IDA	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176910	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05917	Opioid proopiomelanocortin pathway	P06006	beta-Endorphin	MONDO|Ensembl=ENSMODG00000015853|UniProtKB=Q95J84	Proopiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P04398	p53 pathway feedback loops 2	P04660	SIAH-1	DANRE|ZFIN=ZDB-GENE-010319-31|UniProtKB=Q7ZVG6	E3 ubiquitin-protein ligase Siah1	ISS	14985507	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	IC	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	HUMAN|HGNC=2453|UniProtKB=P49674	Casein kinase I isoform epsilon	IDA	11865049	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	MACMU|Ensembl=ENSMMUG00000005530|UniProtKB=F7GFB1	Synaptotagmin I	ISS	1589771	PubMed	PTHR10024:SF239	SYNAPTOTAGMIN-1
P00036	Interleukin signaling pathway	P00965	ERK	PANTR|Ensembl=ENSPTRG00000008867|UniProtKB=H2QCF3	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00048	PI3 kinase pathway	P01199	Galpha	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000008751|UniProtKB=H2QC89	Uncharacterized protein	ISS	129387	gi	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00018	EGF receptor signaling pathway	P00562	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04393	Ras Pathway	P04578	Rho	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	TAS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00056	VEGF signaling pathway	P01408	Akt/PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00052	TGF-beta signaling pathway	P01275	P38	CAEEL|WormBase=WBGene00004055|UniProtKB=Q17446	Mitogen-activated protein kinase pmk-1	TAS	11703092	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	ARATH|TAIR=AT1G79000|UniProtKB=Q9C5X9	Histone acetyltransferase HAC1	TAS	10823891	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00059	p53 pathway	G04702	p53	HUMAN|HGNC=11998|UniProtKB=P04637	Cellular tumor antigen p53	TAS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IGI	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00057	Wnt signaling pathway	P01432	Beta-Catenin	CANLF|Ensembl=ENSCAFG00000005204|UniProtKB=B6V8E6	Catenin beta-1	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00018	EGF receptor signaling pathway	P00564	Rac	DICDI|dictyBase=DDB_G0279605|UniProtKB=P34148	Rho-related protein racB	IGI	4757952	gi	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	MOUSE|MGI=MGI=104756|UniProtKB=B8JK39	Integrin alpha-9	IDA	10209034	PubMed	PTHR23220:SF69	INTEGRIN ALPHA-9
P00059	p53 pathway	P04625	Cdk2	MACMU|Ensembl=ENSMMUG00000018817|UniProtKB=F6ZHC1	Uncharacterized protein	ISS	15660127	PubMed	PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P00005	Angiogenesis	P00256	PLC-gamma	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IDA	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF31	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	CANLF|Ensembl=ENSCAFG00000001097|UniProtKB=E2RCX6	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MACMU|Ensembl=ENSMMUG00000017431|UniProtKB=F7HPP3	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00021	FGF signaling pathway	P00647	SHP2	CANLF|Ensembl=ENSCAFG00000008894|UniProtKB=F1Q3J6	Tyrosine-protein phosphatase non-receptor type	ISS	1382983	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P05913	Enkephalin release	P05972	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04393	Ras Pathway	P04566	Stat 1/3	CHICK|Ensembl=ENSGALG00000003267|UniProtKB=Q6DV79	Signal transducer and activator of transcription 3	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MOUSE|MGI=MGI=102705|UniProtKB=P63213	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IDA	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04393	Ras Pathway	P04566	Stat 1/3	CHICK|Ensembl=ENSGALG00000003267|UniProtKB=Q6DV79	Signal transducer and activator of transcription 3	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P02778	Sulfate assimilation	P03165	Sulfite reductase	BACSU|EnsemblGenome=BSU33440|UniProtKB=O32214	Sulfite reductase [NADPH] flavoprotein alpha-component	ISS			PTHR19384:SF89	SULFITE REDUCTASE  NADPH  FLAVOPROTEIN COMPONENT
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00053	T cell activation	P01298	NFkappaB	MOUSE|MGI=MGI=1099800|UniProtKB=Q9WTK5	Nuclear factor NF-kappa-B p100 subunit	IGI	12574369	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	HUMAN|HGNC=1950|UniProtKB=P11229	Muscarinic acetylcholine receptor M1	ISS	8100450	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00049	Parkinson disease	P01208	Hsp70	TAKRU|Ensembl=ENSTRUG00000003346|UniProtKB=H2S609	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00164	Nectin 1alpha N-terminal fragment	RAT|RGD=620791|UniProtKB=F1LNP8	Poliovirus receptor-related 1	ISS	12376527	PubMed	PTHR23277:SF69	NECTIN-1
P00019	Endothelin signaling pathway	P00590	IP3 R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	IGI	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00052	TGF-beta signaling pathway	P01275	P38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00036	Interleukin signaling pathway	P00964	p90RSK	BOVIN|Ensembl=ENSBTAG00000014447|UniProtKB=A4IFF4	Ribosomal protein S6 kinase	ISS	2779569	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	RAT|RGD=62388|UniProtKB=P35365	5-hydroxytryptamine receptor 5B	IDA			PTHR24247:SF14	5-HYDROXYTRYPTAMINE RECEPTOR 5B
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=1336171|UniProtKB=Q9DAS9	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00057	Wnt signaling pathway	P01452	NFAT	MACMU|Ensembl=ENSMMUG00000022596|UniProtKB=F6Z7T2	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF5	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00056	VEGF signaling pathway	P01417	Raf	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00048	PI3 kinase pathway	P01192	p110	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04393	Ras Pathway	P04543	MEKK1/4	BOVIN|Ensembl=ENSBTAG00000020079|UniProtKB=F1N3T0	Uncharacterized protein	ISS	12052864	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	MACMU|Ensembl=ENSMMUG00000023317|UniProtKB=F6Y514	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	IDA	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	BOVIN|Ensembl=ENSBTAG00000010529|UniProtKB=F1MP23	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF75	FRIZZLED-6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	TAS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00054	Toll receptor signaling pathway	P01358	ERK1	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	CANLF|Ensembl=ENSCAFG00000017040|UniProtKB=E2QYK5	Uncharacterized protein	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00912	Arp2/3	MACMU|Ensembl=ENSMMUG00000006492|UniProtKB=F7H998	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00059	p53 pathway	P04619	HMG1	RAT|Ensembl=ENSRNOG00000058908|UniProtKB=D3ZXR5	Uncharacterized protein	ISS			PTHR13711:SF164	HIGH MOBILITY GROUP PROTEIN B1-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	CAEBR|Gene=CBG05011|UniProtKB=A8WYZ3	Aspartate aminotransferase	ISS			PTHR11879:SF10	ASPARTATE AMINOTRANSFERASE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00018	EGF receptor signaling pathway	P00551	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02778	Sulfate assimilation	P03167	Sulfate adenylyltransferase	SULSO|EnsemblGenome=SSO2912|UniProtKB=Q97UT2	Sulfate adenylyltransferase (Sat)	ISS			PTHR43509:SF1	SUBFAMILY NOT NAMED
P00010	B cell activation	P00379	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ARATH|TAIR=AT1G01560|UniProtKB=Q9LMM5	Mitogen-activated protein kinase 11	IDA			PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05918	p38 MAPK pathway	P05920	MAPKAP-K2	MACMU|Ensembl=ENSMMUG00000023567|UniProtKB=F7HHY8	Uncharacterized protein	ISS	10779545	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00057	Wnt signaling pathway	P01443	Phospholipase C	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	8838325	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00054	Toll receptor signaling pathway	P01369	MKK1	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00056	VEGF signaling pathway	P01420	FAK	CHICK|Ensembl=ENSGALG00000016171|UniProtKB=Q00944	Focal adhesion kinase 1	ISS	9182576	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ORNAN|Ensembl=ENSOANG00000007405|UniProtKB=F7CIV4	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P05731	GABA-B receptor II signaling	P05755	Gbeta	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P02788	Xanthine and guanine salvage pathway	P03247	Xanthine phosphoribosyl transferase	PLAF7|EnsemblGenome=PF10_0121|UniProtKB=Q8IJS1	Hypoxanthine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00053	T cell activation	P01311	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	TAS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05730	Endogenous cannabinoid signaling	P05751	Galpha	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	ISS	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00401	jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	TAS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000018202|UniProtKB=E2RPJ2	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04569	Cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04398	p53 pathway feedback loops 2	P04660	SIAH-1	HUMAN|HGNC=10857|UniProtKB=Q8IUQ4	E3 ubiquitin-protein ligase SIAH1	ISS	11389839	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	PANTR|Ensembl=ENSPTRG00000019449|UniProtKB=H2QV01	Actin related protein 2/3 complex, subunit 1B, 41kDa	ISS	12932731	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00059	p53 pathway	G01579	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00034	Integrin signalling pathway	P00916	Ras	CHICK|Ensembl=ENSGALG00000014033|UniProtKB=E1BTS2	Uncharacterized protein	ISS	9869449	PubMed	PTHR24070:SF186	GTPASE KRAS
P02781	Threonine biosynthesis	P03188	Homoserine dehydrogenase	GLOVI|Gene=BAC92236|UniProtKB=Q7NDE0	Homoserine dehydrogenase	ISS			PTHR43331:SF1	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01146	Ikk	PANTR|Ensembl=ENSPTRG00000033948|UniProtKB=H2RBD4	Conserved helix-loop-helix ubiquitous kinase	RCA			PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01456	beta-arrestin	BOVIN|Gene=ARRB2|UniProtKB=P32120	Beta-arrestin-2	IDA	9388255	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	DANRE|ZFIN=ZDB-GENE-050417-441|UniProtKB=Q567Y8	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P05730	Endogenous cannabinoid signaling	P05748	mGluR	MACMU|Ensembl=ENSMMUG00000010184|UniProtKB=F6SR09	Uncharacterized protein	ISS	92317054	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00046	Oxidative stress response	P01129	JNK1/2	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00012	Cadherin signaling pathway	P00474	Wnt	CAEEL|WormBase=WBGene00003029|UniProtKB=Q27886	Abnormal cell lineage protein 44	ISS	8717036	PubMed	PTHR12027:SF102	PROTEIN WNT-4
P00019	Endothelin signaling pathway	P00572	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00071	VAT1	DROME|FlyBase=FBgn0260964|UniProtKB=Q8IH57	GH10249p	ISS			PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	DEIRA|EnsemblGenome=DR_0485|UniProtKB=Q9RX30	Glutamate--tRNA ligase	ISS			PTHR43311:SF2	GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED
P00057	Wnt signaling pathway	P01431	LRP5/6	BOVIN|Ensembl=ENSBTAG00000011761|UniProtKB=F1MDE1	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PHYIT|EnsemblGenome=PITG_15117|UniProtKB=D0NRP9	Actin-like protein	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	9199552	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	HUMAN|HGNC=703|UniProtKB=Q92747	Actin-related protein 2/3 complex subunit 1A	ISS	12473693	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00034	Integrin signalling pathway	P00923	Arf1	TAKRU|Ensembl=ENSTRUG00000007465|UniProtKB=H2T1E8	Uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF291	ADP-RIBOSYLATION FACTOR 1
P00019	Endothelin signaling pathway	P00591	PLCbeta	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	IGI	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00006	Apoptosis signaling pathway	P00310	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CHICK|Gene=ACTG2|UniProtKB=P63270	Actin, gamma-enteric smooth muscle	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00029	Huntington disease	P00780	Microtubule	HUMAN|HGNC=12412|UniProtKB=Q13885	Tubulin beta-2A chain	IDA	9454836	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00012	Cadherin signaling pathway	P00470	F-actin	MACMU|Ensembl=ENSMMUG00000001353|UniProtKB=F7D6T8	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00037	Ionotropic glutamate receptor pathway	P01026	KA	HUMAN|HGNC=4582|UniProtKB=Q16099	Glutamate receptor ionotropic, kainate 4	ISS	12941441	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	PANTR|Ensembl=ENSPTRG00000012128|UniProtKB=H2QI87	Uncharacterized protein	ISS	12356903	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00034	Integrin signalling pathway	P00907	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00627	ERK1-2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00053	T cell activation	P01309	fos	RAT|RGD=2626|UniProtKB=P12841	Proto-oncogene c-Fos	TAS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	HUMAN|HGNC=1952|UniProtKB=P20309	Muscarinic acetylcholine receptor M3	TAS	12915051	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00021	FGF signaling pathway	P00628	JNK1-3	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00183	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	7798194	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00029	Huntington disease	P00807	Actin	MOUSE|MGI=MGI=87906|UniProtKB=P63260	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00047	PDGF signaling pathway	P01142	p90RSK	MACMU|Ensembl=ENSMMUG00000005483|UniProtKB=F7G271	Uncharacterized protein	ISS	6755374	gi	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000025240|UniProtKB=F7A7I3	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00053	T cell activation	P01307	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00057	Wnt signaling pathway	P01444	Wnt	PANTR|Ensembl=ENSPTRG00000000313|UniProtKB=H2PY99	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01171	PLCgamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	MACMU|Ensembl=ENSMMUG00000007096|UniProtKB=F7ERG6	G protein-activated inward rectifier potassium channel 1	ISS	12374786	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04393	Ras Pathway	P04570	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	IDA	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00060	Ubiquitin proteasome pathway	P01492	E1	HUMAN|HGNC=12471|UniProtKB=P41226	Ubiquitin-like modifier-activating enzyme 7	ISS			PTHR10953:SF143	UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 7
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00057	Wnt signaling pathway	P01431	LRP5/6	MOUSE|MGI=MGI=1298218|UniProtKB=O88572	Low-density lipoprotein receptor-related protein 6	IDA	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00005	Angiogenesis	P00182	p38MAPK	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4401|UniProtKB=O14775	Guanine nucleotide-binding protein subunit beta-5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00025	Hedgehog signaling pathway	P00682	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04398	p53 pathway feedback loops 2	P04665	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02752	Mannose metabolism	P03017	Mannose 6-P isomerase	HUMAN|HGNC=7216|UniProtKB=P34949	Mannose-6-phosphate isomerase	TAS	20563689	gi	PTHR10309:SF0	MANNOSE-6-PHOSPHATE ISOMERASE
P02769	Purine metabolism	P03118	Guanine Deaminase	MACMU|Ensembl=ENSMMUG00000019196|UniProtKB=F7CWS1	Guanine deaminase isoform b	ISS	11837778	gi	PTHR11271:SF6	GUANINE DEAMINASE
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	BACSU|EnsemblGenome=BSU17680|UniProtKB=P0CI79	Thymidylate synthase 1	ISS			PTHR11548:SF1	SUBFAMILY NOT NAMED
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	XENTR|Xenbase=XB-GENE-5932067|UniProtKB=F6RLM5	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF74	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	PANTR|Ensembl=ENSPTRG00000003795|UniProtKB=H2Q3X5	Muscarinic acetylcholine receptor	ISS	12181435	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00045	Notch signaling pathway	P01103	Next	MONDO|Ensembl=ENSMODG00000004910|UniProtKB=F7C1Q4	Delta-like protein	ISS	1286675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00034	Integrin signalling pathway	P00925	MEK	BOVIN|Ensembl=ENSBTAG00000010576|UniProtKB=A4IFH7	MAP2K3 protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00018	EGF receptor signaling pathway	P00564	Rac	MACMU|Ensembl=ENSMMUG00000021075|UniProtKB=F7GY91	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04556	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	PANTR|Ensembl=ENSPTRG00000000387|UniProtKB=H2PYE3	Ribosomal protein S6 kinase	ISS	2779569	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	CANLF|Ensembl=ENSCAFG00000006453|UniProtKB=F6X958	Serine/threonine-protein phosphatase	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IC	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	RAT|RGD=67399|UniProtKB=Q64716	Insulin receptor-related protein	ISS	11182407	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	XENTR|Xenbase=XB-GENE-1031985|UniProtKB=Q6GL68	Transcription factor 7-like 1	ISS	9118222	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05731	GABA-B receptor II signaling	P05754	Ggamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1718748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00542	EGFR	HUMAN|HGNC=3236|UniProtKB=P00533	Epidermal growth factor receptor	ISS	90258888	PubMed	PTHR24416:SF91	EPIDERMAL GROWTH FACTOR RECEPTOR
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	IC	15313841	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00029	Huntington disease	P00786	ARF	MOUSE|MGI=MGI=99436|UniProtKB=P61211	ADP-ribosylation factor-like protein 1	IPI	11752622	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	SCHPO|PomBase=SPAC8C9.03|UniProtKB=P36600	cAMP-dependent protein kinase regulatory subunit	ISS	88234494	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00053	T cell activation	P01324	rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MONDO|Ensembl=ENSMODG00000013820|UniProtKB=F6SF10	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PANTR|Ensembl=ENSPTRG00000032449|UniProtKB=H2R293	Uncharacterized protein	ISS			PTHR22692:SF16	PROTEIN MYO15B
P04398	p53 pathway feedback loops 2	P04665	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00030	Hypoxia response via HIF activation	P00819	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01425	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	7492337	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00053	T cell activation	P01307	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05941	GRK3	BOVIN|Gene=ADRBK2|UniProtKB=P26818	Beta-adrenergic receptor kinase 2	RCA	8288567	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00036	Interleukin signaling pathway	P00990	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00819	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CANLF|Ensembl=ENSCAFG00000016020|UniProtKB=O18840	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CAEEL|WormBase=WBGene00000067|UniProtKB=O45815	ACTin	ISS	14684598	PubMed	PTHR11937:SF352	ACTIN
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	15470041	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00011	Blood coagulation	P00424	uPA	HUMAN|HGNC=9052|UniProtKB=P00749	Urokinase-type plasminogen activator	ISS	137114	gi	PTHR24264:SF38	UROKINASE-TYPE PLASMINOGEN ACTIVATOR
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	RCA	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00034	Integrin signalling pathway	P00907	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00039	Metabotropic glutamate receptor group III pathway	P01043	AC	LEPIN|EnsemblGenome=LA_4008|UniProtKB=Q8EZ52	Adenylate/guanylate cyclase	IC	9874775	PubMed	PTHR16305:SF38	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00018	EGF receptor signaling pathway	P00551	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IGI	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00231	HSP27	MOUSE|MGI=MGI=88515|UniProtKB=P24622	Alpha-crystallin A chain	ISS			PTHR11527:SF36	ALPHA-CRYSTALLIN A CHAIN
P00048	PI3 kinase pathway	P01192	p110	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00965	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IC	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04397	p53 pathway by glucose deprivation	P04641	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	PANTR|Ensembl=ENSPTRG00000012911|UniProtKB=H2QJE2	Uncharacterized protein	ISS	10940259	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IC	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00047	PDGF signaling pathway	P01142	p90RSK	RAT|RGD=1563860|UniProtKB=D3Z8E0	Ribosomal protein S6 kinase	ISS	2779569	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00010	B cell activation	P00397	IKK	PANTR|Ensembl=ENSPTRG00000033948|UniProtKB=H2RBD4	Conserved helix-loop-helix ubiquitous kinase	ISS	9346484	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P06587	Nicotine pharmacodynamics pathway	P06592	CHRNA6	HUMAN|HGNC=15963|UniProtKB=Q15825	Neuronal acetylcholine receptor subunit alpha-6	TAS	15155845	PubMed	PTHR18945:SF82	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-6
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	CANLF|Ensembl=ENSCAFG00000018170|UniProtKB=E2RPM8	Tyrosine-protein kinase receptor	ISS	2983222	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P04397	p53 pathway by glucose deprivation	P04641	Akt	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	G01571	FAS	MOUSE|MGI=MGI=95484|UniProtKB=P25446	Tumor necrosis factor receptor superfamily member 6	IGI	14585074	PubMed	PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT4G01370|UniProtKB=Q39024	Mitogen-activated protein kinase 4	ISS	10514528	PubMed	PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P06959	CCKR signaling map	P07228	MAPK1/3	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	RCA	15153424	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00590	IP3 R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	RAT|RGD=2342|UniProtKB=P08482	Muscarinic acetylcholine receptor M1	TAS	11166329	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00012	Cadherin signaling pathway	P00471	Cadherin	XENTR|Xenbase=XB-GENE-482277|UniProtKB=F6QAX3	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CANLF|Ensembl=ENSCAFG00000010764|UniProtKB=Q28300	Guanine nucleotide-binding protein G(t) subunit alpha-1	ISS	6264430	PubMed	PTHR10218:SF67	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00256	PLC-gamma	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00048	PI3 kinase pathway	P01199	Galpha	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00047	PDGF signaling pathway	P01159	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04395	Vasopressin synthesis	P04597	Signal Peptide	DANRE|ZFIN=ZDB-GENE-030407-2|UniProtKB=F8W5D0	Uncharacterized protein (Fragment)	ISS	6717565	PubMed	PTHR11681:SF13	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00223	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	HUMAN|HGNC=145|UniProtKB=P63267	Actin, gamma-enteric smooth muscle	IC	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P04393	Ras Pathway	P04573	Elk-1	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	11050086	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01418	Paxillin	CAEBR|Gene=CBG09041|UniProtKB=A8X7Y4	Protein CBR-PXL-1	ISS			PTHR24216:SF8	PAXILLIN, ISOFORM F
P00018	EGF receptor signaling pathway	P00546	GAP	BOVIN|Ensembl=ENSBTAG00000011829|UniProtKB=F1MHW1	Uncharacterized protein	ISS	95047432	PubMed	PTHR10194:SF60	NEUROFIBROMIN
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	12810719	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ARATH|TAIR=AT2G42100|UniProtKB=Q8RYC2	Putative actin-5	IC	14684598	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P04393	Ras Pathway	P04558	p38	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	IDA	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00015	Circadian clock system	P00505	Cry	MONDO|Ensembl=ENSMODG00000001579|UniProtKB=F7BWW8	Uncharacterized protein	ISS	14507900	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00053	T cell activation	P01336	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00053	T cell activation	P01300	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00020	FAS signaling pathway	P00615	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	12707323	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00016	Cytoskeletal regulation by Rho GTPase	P00521	Profilin	CHICK|Ensembl=ENSGALG00000010410|UniProtKB=F1NUH4	Profilin	ISS			PTHR13936:SF15	PROFILIN-2
P00017	DNA replication	P00527	Histones	MOUSE|MGI=MGI=2145541|UniProtKB=P68433	Histone H3.1	IDA	12413958	PubMed	PTHR11426:SF167	HISTONE H3.1
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00009	Axon guidance mediated by netrin	P00359	NFAT	HUMAN|HGNC=7778|UniProtKB=Q14934	Nuclear factor of activated T-cells, cytoplasmic 4	IDA	12015605	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00029	Huntington disease	P00794	Hippi	MACMU|Ensembl=ENSMMUG00000008786|UniProtKB=F7F6A6	Intraflagellar transport protein 57 homolog	ISS	11889126	PubMed	PTHR16011:SF0	INTRAFLAGELLAR TRANSPORT PROTEIN 57 HOMOLOG
P02751	Lysine biosynthesis	P03013	Aspartate semialdehyde dehydrogenase	GLOVI|Gene=BAC88958|UniProtKB=Q7NLV2	Aspartate-semialdehyde dehydrogenase	ISS			PTHR10174:SF2	ASPARTATE-SEMIALDEHYDE DEHYDROGENASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	XENTR|Xenbase=XB-GENE-6469705|UniProtKB=Q6P8G3	Actin, alpha sarcomeric/skeletal	ISS	10974003	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P00045	Notch signaling pathway	P01108	Nicastrin	DROME|FlyBase=FBgn0039234|UniProtKB=Q9VC27	Nicastrin	TAS	10993067	PubMed	PTHR21092:SF0	NICASTRIN
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	IDA	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	TAS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00053	T cell activation	P01305	Calmodulin	ANOGA|EnsemblGenome=AGAP010957|UniProtKB=Q7QGY7	AGAP010957-PA (Fragment)	ISS	3885394	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IPI	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IGI	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00009	Axon guidance mediated by netrin	P00364	cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BOVIN|Ensembl=ENSBTAG00000014614|UniProtKB=P62739	Actin, aortic smooth muscle	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	RCA	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04395	Vasopressin synthesis	P04597	Signal Peptide	DANRE|ZFIN=ZDB-GENE-030407-1|UniProtKB=F1QC27	Uncharacterized protein	ISS	6717565	PubMed	PTHR11681:SF14	SUBFAMILY NOT NAMED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CAEEL|WormBase=WBGene00000048|UniProtKB=Q18556	AcetylCholine Receptor	IC	11404397	PubMed	PTHR18945:SF528	ACETYLCHOLINE RECEPTOR
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	G04700	PAI	HUMAN|HGNC=8583|UniProtKB=P05121	Plasminogen activator inhibitor 1	ISS	18092159	gi	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01164	PDK1/2	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	ISS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00052	TGF-beta signaling pathway	P01275	P38	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	TAS	20451058	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00012	Cadherin signaling pathway	P00464	Fyn	PANTR|Ensembl=ENSPTRG00000018521|UniProtKB=H2QTL3	Tyrosine-protein kinase	ISS			PTHR24418:SF296	TYROSINE-PROTEIN KINASE FRK
P06211	BMP/activin signaling pathway-drosophila	P06241	TGFbetaR I	DROME|FlyBase=FBgn0011300|UniProtKB=A1Z7L8	Receptor protein serine/threonine kinase	RCA	9395284	PubMed	PTHR23255:SF71	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IDA	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00539	14-3-3	MOUSE|MGI=MGI=1891917|UniProtKB=Q9CQV8	14-3-3 protein beta/alpha	ISS	1671102	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00048	PI3 kinase pathway	P01177	P110ACT	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00641	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04393	Ras Pathway	P04556	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	8170357	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00053	T cell activation	P01298	NFkappaB	MACMU|Ensembl=ENSMMUG00000002990|UniProtKB=F7GVV0	Uncharacterized protein	ISS	20151924	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00047	PDGF signaling pathway	P01143	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06734	COX2	MOUSE|MGI=MGI=102503|UniProtKB=P00405	Cytochrome c oxidase subunit 2	RCA			PTHR22888:SF9	CYTOCHROME C OXIDASE SUBUNIT 2
P02785	Valine biosynthesis	P03217	Dihydroxy isovalerate reductoisomerase	ARATH|TAIR=AT3G58610|UniProtKB=Q05758	Ketol-acid reductoisomerase, chloroplastic	ISS			PTHR21371:SF1	KETOL-ACID REDUCTOISOMERASE, CHLOROPLASTIC
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CANLF|Ensembl=ENSCAFG00000015708|UniProtKB=F2Z4N0	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00059	p53 pathway	G04694	p110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01300	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	CANLF|Ensembl=ENSCAFG00000008977|UniProtKB=J9P7Q4	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF4	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4
P00029	Huntington disease	P00780	Microtubule	CAEEL|WormBase=WBGene00006538|UniProtKB=P41937	Tubulin beta-4 chain	IDA	12932731	PubMed	PTHR11588:SF89	TUBULIN BETA-4 CHAIN
P06211	BMP/activin signaling pathway-drosophila	P06241	TGFbetaR I	DROME|Gene=Dmel_CG1891|UniProtKB=A0A0B4K7J3	Receptor protein serine/threonine kinase	RCA	9395284	PubMed	PTHR23255:SF72	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	LEIMA|EnsemblGenome=LmjF.18.1080|UniProtKB=Q27687	Protein kinase A catalytic subunit	IC	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00024	Glycolysis	P00680	Phosphoglyceromutase	MYCTU|EnsemblGenome=Rv0489|UniProtKB=P9WIC9	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase	ISS	98295987	PubMed	PTHR11931:SF31	SUBFAMILY NOT NAMED
P00010	B cell activation	P00369	MEKK	MOUSE|MGI=MGI=1346873|UniProtKB=Q61083	Mitogen-activated protein kinase kinase kinase 2	IDA	21735556	gi	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P04398	p53 pathway feedback loops 2	P04665	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02743	Formyltetrahydroformate biosynthesis	P02953	Cobalamin dependent homocysteine transmethylase	DEIRA|EnsemblGenome=DR_0966|UniProtKB=Q9RVQ6	5-methyltetrahydrofolate--homocysteine methyltransferase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000011757|UniProtKB=Q9XT97	Presenilin-1	IDA	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06850	PKCs(3)	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06847	JNK1/2	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	RCA	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00059	p53 pathway	G04700	PAI	MACMU|Ensembl=ENSMMUG00000009926|UniProtKB=F6Y5D7	Uncharacterized protein	ISS	10692390	PubMed	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	ARATH|TAIR=AT4G28860|UniProtKB=Q8LPI7	Protein CASEIN KINASE I-LIKE 4	ISS	10617630	PubMed	PTHR11909:SF97	PROTEIN CASEIN KINASE I-LIKE 3-RELATED
P00021	FGF signaling pathway	P00632	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00049	Parkinson disease	P01229	Pael-R	RAT|RGD=619848|UniProtKB=Q9QYC6	Prosaposin receptor GPR37	IDA	12150907	PubMed	PTHR24243:SF32	PROSAPOSIN RECEPTOR GPR37
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00591	PLCbeta	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	PANTR|Ensembl=ENSPTRG00000011042|UniProtKB=H2QGF5	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00589	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IGI	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05752	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01199	Galpha	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS			PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95817|UniProtKB=Q8BMF5	Glutamate receptor ionotropic, kainate 4	ISS	12778120	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	RAT|RGD=61863|UniProtKB=P19493	Glutamate receptor 4	ISS	12497607	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00019	Endothelin signaling pathway	P00590	IP3 R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	IXOSC|EnsemblGenome=ISCW024111|UniProtKB=B7PBG2	Actin, putative (Fragment)	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IGI	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00036	Interleukin signaling pathway	P00996	STAT	DANRE|ZFIN=ZDB-GENE-030820-2|UniProtKB=Q68SP3	Signal transducer and activator of transcription	IC			PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05912	Dopamine receptor mediated signaling pathway	P05964	GNAZ	TAKRU|Ensembl=ENSTRUG00000008249|UniProtKB=H2T7L2	Uncharacterized protein (Fragment)	ISS	16814816	PubMed	PTHR10218:SF65	GUANINE NUCLEOTIDE-BINDING PROTEIN G Z  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00034	Integrin signalling pathway	P00916	Ras	MONDO|Gene=KRAS|UniProtKB=Q07983	GTPase KRas	ISS	99084794	PubMed	PTHR24070:SF186	GTPASE KRAS
P02728	Arginine biosynthesis	P02842	N-acetylornithine aminotransferase	PYRAE|EnsemblGenome=PAE2515|UniProtKB=Q8ZV07	Acetylornithine/acetyl-lysine aminotransferase	ISS	10074354	PubMed	PTHR11986:SF79	ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01067	AChE	ANOGA|EnsemblGenome=AGAP000466|UniProtKB=Q7QFG0	Carboxylic ester hydrolase	ISS	86008285	PubMed	PTHR43918:SF4	ACETYLCHOLINESTERASE
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00115	Nicastrin	HUMAN|HGNC=17091|UniProtKB=Q92542	Nicastrin	IDA	16096062	PubMed	PTHR21092:SF0	NICASTRIN
P00047	PDGF signaling pathway	P01153	GSK3	MOUSE|MGI=MGI=2152453|UniProtKB=Q2NL51	Glycogen synthase kinase-3 alpha	ISS	12086949	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P06587	Nicotine pharmacodynamics pathway	P06605	KCNK3/9	MACMU|Ensembl=ENSMMUG00000005826|UniProtKB=F6VE51	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-040426-2427|UniProtKB=F1Q6C0	Uncharacterized protein (Fragment)	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	ISS	15860573	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000003872|UniProtKB=E1BIQ3	Uncharacterized protein	ISS			PTHR19957:SF83	SYNTAXIN-16
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00010	B cell activation	P00373	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IGI	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BOVIN|Gene=ACTB|UniProtKB=P60712	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00056	VEGF signaling pathway	P01413	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	ISS	1171954	gi	PTHR10048:SF14	PI-3 KINASE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	ANOGA|EnsemblGenome=AGAP011808|UniProtKB=Q7PZA0	AGAP011808-PA	ISS			PTHR11482:SF6	ORNITHINE DECARBOXYLASE 1-RELATED
P00053	T cell activation	P01324	rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	PANTR|Ensembl=ENSPTRG00000006342|UniProtKB=H2Q8A8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DANRE|ZFIN=ZDB-GENE-030131-172|UniProtKB=Q6IQR3	Actin, alpha, cardiac muscle 1a	IC	10974003	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00046	Oxidative stress response	P01135	p38	CAEEL|WormBase=WBGene00004055|UniProtKB=Q17446	Mitogen-activated protein kinase pmk-1	TAS	10514528	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00021	FGF signaling pathway	P00644	p38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00648	PKC	SCHPO|PomBase=SPAC17G8.14c|UniProtKB=P36582	Protein kinase C-like 1	IGI	8491190	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00019	Endothelin signaling pathway	P00590	IP3 R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	PANTR|Ensembl=ENSPTRG00000022245|UniProtKB=H2QZ29	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01433	SIAH-1	RAT|RGD=620449|UniProtKB=Q920M9	E3 ubiquitin-protein ligase SIAH1	ISS	11389839	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00060	Ubiquitin proteasome pathway	P01492	E1	ARATH|TAIR=AT4G24940|UniProtKB=Q8VY78	SUMO-activating enzyme subunit 1A	ISS			PTHR10953:SF162	SUMO-ACTIVATING ENZYME SUBUNIT 1
P00047	PDGF signaling pathway	P01154	Ras	CHICK|Ensembl=ENSGALG00000006885|UniProtKB=P08642	GTPase HRas	ISS	3035212	PubMed	PTHR24070:SF385	GTPASE HRAS
P00036	Interleukin signaling pathway	P00983	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00018	EGF receptor signaling pathway	P00551	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IGI	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01465	Ggamma	ORNAN|Ensembl=ENSOANG00000013961|UniProtKB=F6VPY1	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00034	Integrin signalling pathway	P00931	Integrin beta	CANLF|Ensembl=ENSCAFG00000013735|UniProtKB=F1PPG5	Integrin beta	IDA	124968	gi	PTHR10082:SF25	INTEGRIN BETA-3
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	HUMAN|HGNC=2861|UniProtKB=P00374	Dihydrofolate reductase	ISS			PTHR22778:SF39	DIHYDROFOLATE REDUCTASE
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	DROME|FlyBase=FBgn0004509|UniProtKB=P26016	Furin-like protease 1, isoforms 1/1-X/2	IDA	7737999	PubMed	PTHR42884:SF3	FURIN-LIKE PROTEASE 1, ISOFORMS 1/1-X/2
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00011	Blood coagulation	P00429	PN2	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	ISS	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04397	p53 pathway by glucose deprivation	P04639	AMPK	RAT|RGD=3388|UniProtKB=P80385	5'-AMP-activated protein kinase subunit gamma-1	ISS			PTHR13780:SF38	5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1
P00019	Endothelin signaling pathway	P00590	IP3 R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01465	Ggamma	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00021	FGF signaling pathway	P00624	14-3-3	MOUSE|MGI=MGI=894689|UniProtKB=P62259	14-3-3 protein epsilon	ISS	9450960	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00852	PYK2	PANTR|Ensembl=ENSPTRG00000020104|UniProtKB=H2QVX8	PTK2B protein tyrosine kinase 2 beta	ISS	12640026	PubMed	PTHR24418:SF94	PROTEIN-TYROSINE KINASE 2-BETA
P00060	Ubiquitin proteasome pathway	P01490	E3	PANTR|Ensembl=ENSPTRG00000013415|UniProtKB=H2R1E1	Uncharacterized protein	ISS			PTHR11254:SF66	E3 UBIQUITIN-PROTEIN LIGASE ITCHY HOMOLOG
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04397	p53 pathway by glucose deprivation	P04636	S6K	DROME|FlyBase=FBgn0283472|UniProtKB=Q94533	Ribosomal protein S6 kinase	IGI			PTHR24351:SF166	RIBOSOMAL PROTEIN S6 KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	CANLF|Ensembl=ENSCAFG00000005685|UniProtKB=E2R481	Uncharacterized protein	ISS			PTHR24361:SF183	SERINE/THREONINE-PROTEIN KINASE PAK 7
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	TAKRU|Ensembl=ENSTRUG00000005608|UniProtKB=H2SM93	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00006	Apoptosis signaling pathway	P00299	Caspase 8	MOUSE|MGI=MGI=1261423|UniProtKB=O89110	Caspase-8	ISS	8681376	PubMed	PTHR10454:SF162	CASPASE-8
P00019	Endothelin signaling pathway	P00590	IP3 R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IGI	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00624	14-3-3	DANRE|ZFIN=ZDB-GENE-011115-1|UniProtKB=Q6PC29	14-3-3 protein gamma-1	ISS	1317796	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P04395	Vasopressin synthesis	P04597	Signal Peptide	DANRE|ZFIN=ZDB-GENE-030407-2|UniProtKB=F8W5D0	Uncharacterized protein (Fragment)	ISS	9756087	PubMed	PTHR11681:SF13	SUBFAMILY NOT NAMED
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	PANTR|Ensembl=ENSPTRG00000039733|UniProtKB=H2RDP9	Actin-related protein 2/3 complex subunit 4	ISS	5031595	gi	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00046	Oxidative stress response	P01131	MKP5	MACMU|Ensembl=ENSMMUG00000015266|UniProtKB=F7DVA0	Dual specificity protein phosphatase 21	ISS			PTHR10159:SF386	DUAL SPECIFICITY PROTEIN PHOSPHATASE 21
P00057	Wnt signaling pathway	P01428	Frizzled	DANRE|ZFIN=ZDB-GENE-990415-218|UniProtKB=B3DIG4	Frizzled homolog 8c	IDA	8717036	PubMed	PTHR11309:SF126	FRIZZLED-5
P00021	FGF signaling pathway	P00629	PP2A	ARATH|TAIR=AT3G25800|UniProtKB=Q38950	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform	ISS			PTHR10648:SF4	PROTEIN PHOSPHATASE 2  FORMERLY 2A , REGULATORY SUBUNIT A, BETA ISOFORM
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00049	Parkinson disease	P01230	Src kinase	PANTR|Ensembl=ENSPTRG00000013474|UniProtKB=H2QKB4	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IDA	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEEL|WormBase=WBGene00004033|UniProtKB=P90980	Protein kinase C-like 2	ISS	2837282	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CAEEL|WormBase=WBGene00000066|UniProtKB=P10986	Actin-4	IDA	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00018	EGF receptor signaling pathway	P00561	STAT	CHICK|Ensembl=ENSGALG00000003282|UniProtKB=O93378	Signal transducer and activator of transcription	IGI	20119183	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	HUMAN|HGNC=4587|UniProtKB=Q14957	Glutamate receptor ionotropic, NMDA 2C	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	CANLF|Ensembl=ENSCAFG00000028654|UniProtKB=J9P702	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00005	Angiogenesis	P00213	FGF	RAT|RGD=2609|UniProtKB=P13109	Fibroblast growth factor 2	ISS	12788918	PubMed	PTHR11486:SF83	FIBROBLAST GROWTH FACTOR 2
P00053	T cell activation	P01318	PKC-theta	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00048	PI3 kinase pathway	P01181	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00057	Wnt signaling pathway	P01443	Phospholipase C	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P06664	Gonadotropin-releasing hormone receptor pathway	P06726	GC	MOUSE|MGI=MGI=2660873|UniProtKB=Q8BXH3	Protein Gucy1b2	RCA			PTHR11920:SF451	GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1354946|UniProtKB=Q61532	Mitogen-activated protein kinase 6	ISS	8444355	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00029	Huntington disease	P00807	Actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	IDA	10974003	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	DICDI|dictyBase=DDB_G0288679|UniProtKB=Q03479	Myosin IE heavy chain	IC			PTHR13140:SF729	MYOSIN 95E, ISOFORM E
P00018	EGF receptor signaling pathway	P00561	STAT	CANLF|Ensembl=ENSCAFG00000000163|UniProtKB=F1PAY3	Signal transducer and activator of transcription	ISS	8085155	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00029	Huntington disease	P00780	Microtubule	CHLRE|EnsemblGenome=CHLREDRAFT_129868|UniProtKB=A8IXZ0	Beta tubulin 1	IDA	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04393	Ras Pathway	P04555	PDK	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	IDA	15210700	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00045	Notch signaling pathway	P01115	Neurotic	CANLF|Gene=FUT8|UniProtKB=Q659X0	Alpha-(1,6)-fucosyltransferase	ISS			PTHR13132:SF29	ALPHA- 1,6 -FUCOSYLTRANSFERASE
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DROME|FlyBase=FBgn0030011|UniProtKB=Q9W3J1	Gbeta5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	PANTR|Ensembl=ENSPTRG00000008185|UniProtKB=H2QB89	Aspartate aminotransferase	ISS			PTHR11879:SF32	ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05916	Opioid prodynorphin pathway	P06001	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	DANRE|ZFIN=ZDB-GENE-040426-1013|UniProtKB=Q6P0T2	Transcription initiation factor TFIID subunit 8	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00056	VEGF signaling pathway	P01420	FAK	MONDO|Ensembl=ENSMODG00000000707|UniProtKB=F6WLE6	Uncharacterized protein	ISS	12640026	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00017	DNA replication	P00527	Histones	TAKRU|Ensembl=ENSTRUG00000012002|UniProtKB=H2U0B9	Histone H3	ISS	12413958	PubMed	PTHR11426:SF184	HISTONE H3.1T
P00057	Wnt signaling pathway	P01438	PP2A	BOVIN|Ensembl=ENSBTAG00000000469|UniProtKB=P67774	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00052	TGF-beta signaling pathway	P01284	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IDA	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00059	p53 pathway	G04694	p110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CAEBR|Gene=CBG02167|UniProtKB=A8WS37	Protein CBG02167	ISS	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2747|UniProtKB=P35349	Metabotropic glutamate receptor 6	IDA	12351712	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00047	PDGF signaling pathway	P01159	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CHICK|Ensembl=ENSGALG00000009640|UniProtKB=F1P0I0	Muscarinic acetylcholine receptor	IDA	8100450	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	15210700	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00029	Huntington disease	P00775	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00059	p53 pathway	G04694	p110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	IDA	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00005	Angiogenesis	P00182	p38MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00047	PDGF signaling pathway	P01157	MAPKAPK2	BOVIN|Ensembl=ENSBTAG00000038107|UniProtKB=F1MCX5	Uncharacterized protein	ISS	10779545	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	8170357	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=620146|UniProtKB=O08874	Serine/threonine-protein kinase N2	ISS	11554554	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00048	PI3 kinase pathway	P01177	P110ACT	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	IDA	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00034	Integrin signalling pathway	P00942	Fyn	DANRE|ZFIN=ZDB-GENE-050706-89|UniProtKB=F1RDG9	Tyrosine-protein kinase fynb	ISS	9741627	PubMed	PTHR24418:SF242	TYROSINE-PROTEIN KINASE FYNB
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04393	Ras Pathway	P04563	Ets	BOVIN|Ensembl=ENSBTAG00000002341|UniProtKB=A5PJG9	ETS1 protein	ISS	15579511	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06773	gnai/o	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00030	Hypoxia response via HIF activation	P00824	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	DICPU|Gene=DICPUDRAFT_26270|UniProtKB=F0Z8A7	Protein serine/threonine kinase	ISS	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01451	Galpha	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04393	Ras Pathway	P04558	p38	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	IDA	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00048	PI3 kinase pathway	P01199	Galpha	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	RCA			PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01189	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	TAS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	10693759	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MACMU|Gene=CCR2|UniProtKB=O18793	C-C chemokine receptor type 2	ISS			PTHR10489:SF913	C-C CHEMOKINE RECEPTOR TYPE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00059	p53 pathway	P01486	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00015	Circadian clock system	G01501	cry	CHICK|Gene=CRY1|UniProtKB=Q8QG61	Cryptochrome-1	ISS			PTHR11455:SF16	CRYPTOCHROME-1
P00004	Alzheimer disease-presenilin pathway	P00126	Fe65	MOUSE|MGI=MGI=107765|UniProtKB=Q9QXJ1	Amyloid beta A4 precursor protein-binding family B member 1	IDA	15115822	PubMed	PTHR14058:SF5	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1
P00018	EGF receptor signaling pathway	P00561	STAT	RAT|RGD=1309063|UniProtKB=Q1KQ07	Signal transducer and activator of transcription	ISS	12039028	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	HUMAN|HGNC=1401|UniProtKB=Q02641	Voltage-dependent L-type calcium channel subunit beta-1	IDA	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00034	Integrin signalling pathway	P00945	Parvin	DANRE|ZFIN=ZDB-GENE-040721-2|UniProtKB=Q6DRM4	Actopaxin	ISS	11331308	PubMed	PTHR12114:SF6	ALPHA-PARVIN
P05915	Opioid proenkephalin pathway	P05994	G-protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CAEBR|Gene=CBG23090|UniProtKB=A8Y4R0	Protein CBG23090	ISS	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	HUMAN|HGNC=237|UniProtKB=O43306	Adenylate cyclase type 6	IDA	2491850	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00005	Angiogenesis	P00205	GAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	ISS	88318957	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00205	GAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00047	PDGF signaling pathway	P01143	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MACMU|Ensembl=ENSMMUG00000013656|UniProtKB=F7GI70	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF126	FRIZZLED-5
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00036	Interleukin signaling pathway	P00996	STAT	MACMU|Ensembl=ENSMMUG00000010705|UniProtKB=F7G8V4	Signal transducer and activator of transcription	ISS	95236292	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=1197020|UniProtKB=O35468	Protein Wnt-9b	IDA	8717036	PubMed	PTHR12027:SF84	PROTEIN WNT-9B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00870	IL2	HUMAN|HGNC=6001|UniProtKB=P60568	Interleukin-2	RCA			PTHR45426:SF1	INTERLEUKIN-2
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	TAKRU|Ensembl=ENSTRUG00000003442|UniProtKB=H2S6Q5	Uncharacterized protein	ISS			PTHR23050:SF197	CALMODULIN-LIKE PROTEIN 3
P00018	EGF receptor signaling pathway	P00562	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00010	B cell activation	P00380	fos	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	TAS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P02783	Tryptophan biosynthesis	P03209	Anthranilate phosphoribosyl transferase	SCHPO|PomBase=SPBC16G5.08|UniProtKB=O60122	Anthranilate phosphoribosyltransferase	ISS			PTHR43285:SF2	ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	IXOSC|EnsemblGenome=ISCW017133|UniProtKB=B7PA92	Beta tubulin	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	HUMAN|HGNC=705|UniProtKB=O15144	Actin-related protein 2/3 complex subunit 2	ISS	10940259	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	PANTR|Ensembl=ENSPTRG00000022187|UniProtKB=Q7YQL4	Serine/threonine-protein kinase PAK 3	ISS	11259591	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00016	Cytoskeletal regulation by Rho GTPase	P00521	Profilin	YEAST|SGD=S000005648|UniProtKB=P07274	Profilin	ISS			PTHR11604:SF0	PROFILIN
P00018	EGF receptor signaling pathway	P00545	JNK1-3	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IGI	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01161	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	ORNAN|Ensembl=ENSOANG00000004058|UniProtKB=F6TYP9	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00948	Rho	MONDO|Ensembl=ENSMODG00000000981|UniProtKB=F7ES59	Uncharacterized protein	ISS	14871999	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=5291|UniProtKB=P28566	5-hydroxytryptamine receptor 1E	IDA	1608964	PubMed	PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	CAEEL|WormBase=WBGene00000055|UniProtKB=P48180	Acetylcholine receptor subunit alpha-type acr-16	ISS	11404397	PubMed	PTHR18945:SF578	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-TYPE ACR-16
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00552	Ras	DANRE|ZFIN=ZDB-GENE-990415-166|UniProtKB=P79737	GTPase NRas	ISS	9116869	PubMed	PTHR24070:SF189	GTPASE NRAS
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MOUSE|MGI=MGI=87902|UniProtKB=P68134	Actin, alpha skeletal muscle	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00470	F-actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g210933|UniProtKB=A7SEA7	Predicted protein	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04393	Ras Pathway	P04542	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00021	FGF signaling pathway	P00629	PP2A	TAKRU|Ensembl=ENSTRUG00000011169|UniProtKB=H2TU36	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00038	JAK/STAT signaling pathway	P01031	PIAS	PANTR|Ensembl=ENSPTRG00000001206|UniProtKB=H2PZU2	Uncharacterized protein	ISS	8682149	PubMed	PTHR10782:SF10	E3 SUMO-PROTEIN LIGASE PIAS3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00055	Transcription regulation by bZIP transcription factor	P01398	TFIIEalpha	MACMU|Ensembl=ENSMMUG00000001596|UniProtKB=F7GV34	General transcription factor IIE subunit 1	ISS	189964	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00717	Phosphorylase b	CANLF|Ensembl=ENSCAFG00000014595|UniProtKB=F1PB77	Alpha-1,4 glucan phosphorylase	ISS	4318782	PubMed	PTHR11468:SF12	GLYCOGEN PHOSPHORYLASE, LIVER FORM
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	HUMAN|HGNC=15471|UniProtKB=Q9H2A2	Aldehyde dehydrogenase family 8 member A1	IC			PTHR43720:SF2	ALDEHYDE DEHYDROGENASE FAMILY 8 MEMBER A1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=1339709|UniProtKB=P13541	Myosin-3	ISS	89264452	PubMed	PTHR13140:SF427	MYOSIN-3
P00048	PI3 kinase pathway	P01202	p85	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00007	Axon guidance mediated by semaphorins	P00339	CRMP	BOVIN|Ensembl=ENSBTAG00000018373|UniProtKB=O02675	Dihydropyrimidinase-related protein 2	ISS	Q90635	SPACC	PTHR11647:SF56	DIHYDROPYRIMIDINASE-RELATED PROTEIN 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00931	Integrin beta	PANTR|Ensembl=ENSPTRG00000024336|UniProtKB=H2R464	Integrin, beta-like 1 (With EGF-like repeat domains)	ISS	3487386	PubMed	PTHR10082:SF3	INTEGRIN BETA-LIKE PROTEIN 1
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MOUSE|MGI=MGI=1858210|UniProtKB=O70439	Syntaxin-7	ISS	10321247	PubMed	PTHR19957:SF90	SYNTAXIN-7
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00023	General transcription regulation	P00666	TFIIE	RAT|RGD=1310134|UniProtKB=D3ZCP9	Transcription initiation factor IIE subunit beta	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	176910	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00565	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IC	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00025	Hedgehog signaling pathway	P00692	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00221	JNK1	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00774	Dynein complex	CANLF|Ensembl=ENSCAFG00000017436|UniProtKB=E2RFR5	Uncharacterized protein	ISS	9454836	PubMed	PTHR11886:SF35	DYNEIN LIGHT CHAIN 2, CYTOPLASMIC
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	CANLF|Gene=ADCY6|UniProtKB=P30804	Adenylate cyclase type 6	IDA	92409599	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02730	Asparagine and aspartate biosynthesis	P02853	Asparagine synthetase	HUMAN|HGNC=753|UniProtKB=P08243	Asparagine synthetase [glutamine-hydrolyzing]	ISS			PTHR11772:SF23	ASPARAGINE SYNTHETASE  GLUTAMINE-HYDROLYZING
P00034	Integrin signalling pathway	P00912	Arp2/3	PANTR|Ensembl=ENSPTRG00000012911|UniProtKB=H2QJE2	Uncharacterized protein	ISS	17943202	gi	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MACMU|Ensembl=ENSMMUG00000005238|UniProtKB=F7BWT2	Uncharacterized protein	ISS	11701344	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00048	PI3 kinase pathway	P01177	P110ACT	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04407	K+ channel	BOVIN|Ensembl=ENSBTAG00000047488|UniProtKB=G3N1D1	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00019	Endothelin signaling pathway	P00566	ERK	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	NAS	12001934	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	MOUSE|MGI=MGI=87912|UniProtKB=P27040	Activin receptor type-2B	TAS	9395284	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IDA	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00025	Hedgehog signaling pathway	P00691	CBP	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00029	Huntington disease	P00811	Arp2/3 complex	HUMAN|HGNC=703|UniProtKB=Q92747	Actin-related protein 2/3 complex subunit 1A	TAS	12932731	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00034	Integrin signalling pathway	P00932	FAK	BOVIN|Ensembl=ENSBTAG00000005958|UniProtKB=F1N0Z0	Uncharacterized protein	ISS	10753828	PubMed	PTHR24418:SF94	PROTEIN-TYROSINE KINASE 2-BETA
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00001	Adrenaline and noradrenaline biosynthesis	P00071	VAT1	PANTR|Ensembl=ENSPTRG00000002979|UniProtKB=H2Q2M8	Uncharacterized protein	ISS			PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	IC	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	MACMU|Ensembl=ENSMMUG00000014486|UniProtKB=F7GH95	Ras-related protein Rap-1A	ISS	8576107	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00035	Interferon-gamma signaling pathway	P00956	SOCS	PANTR|Ensembl=ENSPTRG00000010105|UniProtKB=H2QEP3	Suppressor of cytokine signaling 6	ISS	12645661	PubMed	PTHR44562:SF1	SUPPRESSOR OF CYTOKINE SIGNALING 6
P00009	Axon guidance mediated by netrin	P00363	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02751	Lysine biosynthesis	P03009	Aspartokinase	METAC|EnsemblGenome=MA_0131|UniProtKB=Q8TUD6	Aspartokinase	ISS			PTHR21499:SF37	SUBFAMILY NOT NAMED
P00020	FAS signaling pathway	P00600	PARP	RAT|RGD=1305189|UniProtKB=Q5U2U3	Poly [ADP-ribose] polymerase	ISS	12101391	PubMed	PTHR10459:SF66	POLY  ADP-RIBOSE  POLYMERASE 3
P00049	Parkinson disease	P01219	SAPK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00036	Interleukin signaling pathway	P00979	MAPKAPK2	PANTR|Ensembl=ENSPTRG00000001915|UniProtKB=H2Q104	Mitogen-activated protein kinase-activated protein kinase 2	ISS	9628873	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	RAT|RGD=2732|UniProtKB=P22756	Glutamate receptor ionotropic, kainate 1	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P05731	GABA-B receptor II signaling	P05754	Ggamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	MACMU|Ensembl=ENSMMUG00000014334|UniProtKB=F7CYY6	Uncharacterized protein	ISS	2039532	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MONDO|Ensembl=ENSMODG00000025248|UniProtKB=F7F5X1	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00018	EGF receptor signaling pathway	P00545	JNK1-3	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00029	Huntington disease	P00790	beta-Tubulin	PANTR|Ensembl=ENSPTRG00000023373|UniProtKB=G2HHT2	Tubulin beta-2C chain	ISS	12932731	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00034	Integrin signalling pathway	P00945	Parvin	RAT|RGD=1311485|UniProtKB=D3ZKG5	Protein Parvb	ISS	11331308	PubMed	PTHR12114:SF7	BETA-PARVIN
P00046	Oxidative stress response	P01138	MKK4	PANTR|Ensembl=ENSPTRG00000008783|UniProtKB=H2QCA7	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00047	PDGF signaling pathway	P01154	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P05731	GABA-B receptor II signaling	P05754	Ggamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	RCA	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00021	FGF signaling pathway	P00640	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00020	FAS signaling pathway	P00594	Caspase8	HUMAN|HGNC=1876|UniProtKB=O15519	CASP8 and FADD-like apoptosis regulator	IGI	9217161	PubMed	PTHR10454:SF8	CASP8 AND FADD-LIKE APOPTOSIS REGULATOR
P00034	Integrin signalling pathway	P00925	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-486685|UniProtKB=F6VT32	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00045	Notch signaling pathway	P01116	Delta	HUMAN|HGNC=2909|UniProtKB=Q9NYJ7	Delta-like protein 3	IC	10742114	PubMed	PTHR24044:SF308	DELTA-LIKE PROTEIN 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	DROME|FlyBase=FBgn0039157|UniProtKB=Q4AB27	Myosin 95E, isoform E	IC			PTHR13140:SF729	MYOSIN 95E, ISOFORM E
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CANLF|Ensembl=ENSCAFG00000013148|UniProtKB=Q5R1P3	Glutamate receptor ionotropic, NMDA 2B	IC	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06783	Zeb1	MOUSE|MGI=MGI=1344313|UniProtKB=Q64318	Zinc finger E-box-binding homeobox 1	RCA			PTHR24391:SF17	ZINC FINGER E-BOX-BINDING HOMEOBOX 1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	PANTR|Ensembl=ENSPTRG00000007605|UniProtKB=H2QAA6	Nucleoside diphosphate kinase	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P00057	Wnt signaling pathway	P01431	LRP5/6	HUMAN|HGNC=6697|UniProtKB=O75197	Low-density lipoprotein receptor-related protein 5	IDA	11029006	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00047	PDGF signaling pathway	P01154	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	91232861	PubMed	PTHR24070:SF385	GTPASE HRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00056	VEGF signaling pathway	P01418	Paxillin	MACMU|Ensembl=ENSMMUG00000000896|UniProtKB=F6T778	Uncharacterized protein	ISS			PTHR24216:SF27	TRANSFORMING GROWTH FACTOR BETA-1-INDUCED TRANSCRIPT 1 PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BOVIN|Gene=ACTG2|UniProtKB=Q5E9B5	Actin, gamma-enteric smooth muscle	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01161	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00048	PI3 kinase pathway	P01185	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IDA	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00029	Huntington disease	P00788	Calpain	HUMAN|HGNC=1483|UniProtKB=Q9Y6Q1	Calpain-6	IDA	11675509	PubMed	PTHR10183:SF381	CALPAIN-6
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IDA	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01331	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00010	B cell activation	P00383	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IDA	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00049	Parkinson disease	P01211	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	CHICK|Gene=PSEN2|UniProtKB=Q90X07	Presenilin-2	IDA	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-9966|UniProtKB=Q6TH03	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00010	B cell activation	P00383	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06812	L-type Ca2+	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	RCA	15621031	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00009	Axon guidance mediated by netrin	P00366	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	10891487	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00029	Huntington disease	P00766	Htt	HUMAN|HGNC=4851|UniProtKB=P42858	Huntingtin	IDA	9462744	PubMed	PTHR10170:SF10	HUNTINGTIN
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CAEEL|WormBase=WBGene00006454|UniProtKB=G5EEN8	AEX-4	IC			PTHR19305:SF10	AEX-4
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00243	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01181	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00024	Glycolysis	P00680	Phosphoglyceromutase	MOUSE|MGI=MGI=1098242|UniProtKB=P15327	Bisphosphoglycerate mutase	ISS	2542247	PubMed	PTHR11931:SF11	BISPHOSPHOGLYCERATE MUTASE
P04393	Ras Pathway	P04570	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IDA	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00057	Wnt signaling pathway	P01465	Ggamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	MOUSE|MGI=MGI=1920431|UniProtKB=Q8K120	Nuclear factor of activated T-cells, cytoplasmic 4	ISS	9462517	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00019	Endothelin signaling pathway	P00577	PI3K	DROME|FlyBase=FBgn0015278|UniProtKB=Q7K3H0	LD28067p	IGI	96278830	PubMed	PTHR10048:SF64	LD28067P
P00018	EGF receptor signaling pathway	P00551	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12539654	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00475	Frizzled	MACMU|Ensembl=ENSMMUG00000007486|UniProtKB=F6QL95	Frizzled-3	ISS	12549854	PubMed	PTHR11309:SF22	FRIZZLED-3
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00017	DNA replication	P00527	Histones	IXOSC|EnsemblGenome=ISCW002300|UniProtKB=B7P7T4	Histone H3	ISS	12413958	PubMed	PTHR11426:SF179	HISTONE H3.3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ORYSJ|EnsemblGenome=OS03G0718100|UniProtKB=Q10DV7	Actin-1	IC	11889126	PubMed	PTHR11937:SF364	ACTIN-11
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MONDO|Ensembl=ENSMODG00000005623|UniProtKB=F7CFG8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00029	Huntington disease	P00796	Kainate receptor	RAT|RGD=2734|UniProtKB=Q01812	Glutamate receptor ionotropic, kainate 4	IDA	12941441	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00059	p53 pathway	P04630	PP2A	HUMAN|HGNC=9299|UniProtKB=P67775	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PHYPA|Gene=PHYPADRAFT_172686|UniProtKB=A9TYG6	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00047	PDGF signaling pathway	P01169	Vav	MOUSE|MGI=MGI=102718|UniProtKB=Q60992	Guanine nucleotide exchange factor VAV2	ISS	14623913	PubMed	PTHR22826:SF95	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV2
P00019	Endothelin signaling pathway	P00587	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	MOUSE|MGI=MGI=1929772|UniProtKB=Q9EQF6	Dihydropyrimidinase-related protein 5	IPI	11034345	PubMed	PTHR11647:SF58	DIHYDROPYRIMIDINASE-RELATED PROTEIN 5
P00005	Angiogenesis	P00254	GTPase	ORNAN|Ensembl=ENSOANG00000008835|UniProtKB=F7FR08	Uncharacterized protein	ISS	13679859	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00566	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00385	Rac	MACMU|Ensembl=ENSMMUG00000021075|UniProtKB=F7GY91	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	MYCTU|EnsemblGenome=Rv1384|UniProtKB=P9WPK3	Carbamoyl-phosphate synthase large chain	ISS			PTHR11405:SF5	CAD PROTEIN
P00021	FGF signaling pathway	P00638	PLCgamma	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00059	p53 pathway	P01480	PTEN	XENTR|Xenbase=XB-GENE-491433|UniProtKB=B1H2U0	Pten protein	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04395	Vasopressin synthesis	P04597	Signal Peptide	DANRE|ZFIN=ZDB-GENE-030407-1|UniProtKB=F1QC27	Uncharacterized protein	ISS	9756087	PubMed	PTHR11681:SF14	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	PANTR|Ensembl=ENSPTRG00000017236|UniProtKB=H2QRH6	Uncharacterized protein	ISS	11266476	PubMed	PTHR10373:SF33	TRANSCRIPTION FACTOR 7
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00018	EGF receptor signaling pathway	P00551	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00565	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04567	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00019	Endothelin signaling pathway	P00567	PKG	DROME|FlyBase=FBgn0000442|UniProtKB=Q03042	cGMP-dependent protein kinase, isozyme 1	ISS			PTHR24353:SF90	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01015	Glu4	TAKRU|Ensembl=ENSTRUG00000011517|UniProtKB=H2TWL9	Uncharacterized protein (Fragment)	ISS	12941441	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	HUMAN|HGNC=4401|UniProtKB=O14775	Guanine nucleotide-binding protein subunit beta-5	RCA	10051575	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P02738	De novo purine biosynthesis	P02909	GDP reductase	CAEEL|WormBase=WBGene00004391|UniProtKB=Q03604	Ribonucleoside-diphosphate reductase large subunit	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00126	Fe65	MOUSE|MGI=MGI=108404|UniProtKB=Q8R1C9	Amyloid beta A4 precursor protein-binding family B member 3	IDA			PTHR14058:SF10	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 3
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00056	VEGF signaling pathway	P01413	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00589	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00967	c-fos	MACMU|Ensembl=ENSMMUG00000010574|UniProtKB=A5A6H2	C-fos	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00007	Axon guidance mediated by semaphorins	P00340	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04393	Ras Pathway	P04557	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00047	PDGF signaling pathway	P01153	GSK3	ARATH|TAIR=AT4G18710|UniProtKB=Q39011	Shaggy-related protein kinase eta	ISS	21361340	gi	PTHR24057:SF5	SHAGGY-RELATED PROTEIN KINASE ETA
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MOUSE|MGI=MGI=96273|UniProtKB=Q64264	5-hydroxytryptamine receptor 1A	ISS	12441358	PubMed	PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TRIAD|EnsemblGenome=TriadG35956|UniProtKB=Q7YTV5	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00034	Integrin signalling pathway	P00951	Jnk	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05918	p38 MAPK pathway	P05919	MAPKAP-K3	MACMU|Ensembl=ENSMMUG00000010495|UniProtKB=F7BFL2	MAP kinase-activated protein kinase 3	ISS	11335727	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01451	Galpha	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00019	Endothelin signaling pathway	P00587	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00007	Axon guidance mediated by semaphorins	P00341	Rho	CHICK|Ensembl=ENSGALG00000003806|UniProtKB=O93467	GTP-binding protein	ISS	12169092	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00012	Cadherin signaling pathway	P00467	alpha-catenin	HUMAN|HGNC=2509|UniProtKB=P35221	Catenin alpha-1	ISS	9362521	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02776	Serine glycine biosynthesis	P03159	Phosphoserine phosphatase	YEAST|SGD=S000003440|UniProtKB=P42941	Phosphoserine phosphatase	ISS			PTHR43344:SF2	PHOSPHOSERINE PHOSPHATASE
P00005	Angiogenesis	P00221	JNK1	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01154	Ras	BOVIN|Ensembl=ENSBTAG00000009778|UniProtKB=E1BMX0	Uncharacterized protein	ISS	3023884	PubMed	PTHR24070:SF186	GTPASE KRAS
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00034	Integrin signalling pathway	P00912	Arp2/3	DROME|FlyBase=FBgn0001961|UniProtKB=O97182	Actin related complex p41 subunit	IPI	12963527	gi	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P06664	Gonadotropin-releasing hormone receptor pathway	P06817	BMP2/4/15	MOUSE|MGI=MGI=88180|UniProtKB=P21275	Bone morphogenetic protein 4	RCA	9759503	PubMed	PTHR11848:SF165	BONE MORPHOGENETIC PROTEIN 4
P00010	B cell activation	P00381	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02728	Arginine biosynthesis	P02841	argininosuccinate lyase	CANAL|CGD=CAL0004142|UniProtKB=Q59R31	Argininosuccinate lyase	ISS			PTHR43814:SF1	ARGININOSUCCINATE LYASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00018	EGF receptor signaling pathway	P00550	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12162872	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	CHICK|Ensembl=ENSGALG00000011621|UniProtKB=F1NVD2	Uncharacterized protein	ISS	13642251	gi	PTHR15071:SF17	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PANTR|Ensembl=ENSPTRG00000013428|UniProtKB=H2QK88	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF358	MYOSIN-7B
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00015	Circadian clock system	P00502	Casein kinase I	PANTR|Ensembl=ENSPTRG00000014365|UniProtKB=H2R0C8	Casein kinase 1, epsilon	ISS	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	DEIRA|EnsemblGenome=DR_0668|UniProtKB=Q9RWK0	Carbamoyl-phosphate synthase large chain	ISS			PTHR11405:SF5	CAD PROTEIN
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	ISS	15313841	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MACMU|Ensembl=ENSMMUG00000020810|UniProtKB=F7H7P6	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF84	PROTEIN WNT-9B
P00019	Endothelin signaling pathway	P00572	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00034	Integrin signalling pathway	P00947	Laminin	MOUSE|MGI=MGI=96743|UniProtKB=P02469	Laminin subunit beta-1	IPI	2538453	PubMed	PTHR10574:SF233	LAMININ SUBUNIT BETA-1
P00036	Interleukin signaling pathway	P00983	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	TAS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	XENTR|Xenbase=XB-GENE-6067221|UniProtKB=F6Z0J4	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MOUSE|MGI=MGI=95770|UniProtKB=P30678	Guanine nucleotide-binding protein subunit alpha-15	IC	10629036	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P00060	Ubiquitin proteasome pathway	P01491	E2	BOVIN|Ensembl=ENSBTAG00000048291|UniProtKB=G3MY62	Uncharacterized protein	ISS			PTHR24068:SF48	UBIQUITIN-CONJUGATING ENZYME E2 D3
P00018	EGF receptor signaling pathway	P00562	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Ensembl=ENSCAFG00000010787|UniProtKB=E2R3W6	Uncharacterized protein	ISS	2039532	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00005	Angiogenesis	P00249	PAK	HUMAN|HGNC=8590|UniProtKB=Q13153	Serine/threonine-protein kinase PAK 1	IDA	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00059	p53 pathway	P01486	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	TAS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01128	MEF-2	CAEBR|Gene=CBG12442|UniProtKB=A8XFG0	Protein CBR-MEF-2	ISS	11274345	PubMed	PTHR11945:SF277	MYOCYTE-SPECIFIC ENHANCER FACTOR 2
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	18021322	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00034	Integrin signalling pathway	P00925	MEK	HUMAN|HGNC=6844|UniProtKB=P45985	Dual specificity mitogen-activated protein kinase kinase 4	IDA	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04398	p53 pathway feedback loops 2	P04651	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00047	PDGF signaling pathway	P01174	Rho	MOUSE|MGI=MGI=2152936|UniProtKB=Q91Z69	SLIT-ROBO Rho GTPase-activating protein 1	ISS			PTHR14166:SF15	SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 1
P00006	Apoptosis signaling pathway	P00300	Caspase 7	HUMAN|HGNC=1508|UniProtKB=P55210	Caspase-7	ISS	14583630	PubMed	PTHR10454:SF31	CASPASE-7
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04393	Ras Pathway	P04556	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	HUMAN|HGNC=2458|UniProtKB=Q8NEV1	Casein kinase II subunit alpha 3	IDA	10617630	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	ARATH|TAIR=AT1G75780|UniProtKB=P12411	Tubulin beta-1 chain	ISS	9454836	PubMed	PTHR11588:SF116	TUBULIN BETA-1 CHAIN-RELATED
P00054	Toll receptor signaling pathway	P01353	TANK	HUMAN|HGNC=11562|UniProtKB=Q92844	TRAF family member-associated NF-kappa-B activator	ISS			PTHR15249:SF0	TRAF FAMILY MEMBER-ASSOCIATED NF-KAPPA-B ACTIVATOR
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	15313841	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CANLF|Ensembl=ENSCAFG00000008756|UniProtKB=F2Z4N8	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P05731	GABA-B receptor II signaling	P05754	Ggamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	XENTR|Xenbase=XB-GENE-972398|UniProtKB=F7CS21	Uncharacterized protein	ISS			PTHR10943:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MOUSE|MGI=MGI=104617|UniProtKB=P51676	C-C chemokine receptor 1-like protein 1	IC			PTHR10489:SF923	C-C CHEMOKINE RECEPTOR 1-LIKE PROTEIN 1
P00010	B cell activation	P00402	Jnk	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IDA	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00015	Circadian clock system	P00501	Clock	PANTR|Ensembl=ENSPTRG00000016072|UniProtKB=H2QPH9	Clock homolog	ISS	8171325	PubMed	PTHR23042:SF2	CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT
P00020	FAS signaling pathway	P00620	CytochromeC	SCHPO|PomBase=SPBC29A3.18|UniProtKB=O59680	Cytochrome c1, heme protein, mitochondrial	IGI	9027315	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06794	MAP2K1/2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	RCA	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	BOVIN|Ensembl=ENSBTAG00000020887|UniProtKB=F1MP22	Uncharacterized protein	ISS	14624853	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00050	Plasminogen activating cascade	P01254	pro-MMP-13	MOUSE|MGI=MGI=1340026|UniProtKB=P33435	Collagenase 3	ISS	1383028	PubMed	PTHR10201:SF165	COLLAGENASE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00052	TGF-beta signaling pathway	P01275	P38	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	4506785	gi	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04393	Ras Pathway	P04566	Stat 1/3	TAKRU|Ensembl=ENSTRUG00000015348|UniProtKB=H2UQK9	Signal transducer and activator of transcription	ISS	11879641	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00005	Angiogenesis	P00190	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	2842690	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P06959	CCKR signaling map	P07042	CCK2R	HUMAN|HGNC=1571|UniProtKB=P32239	Gastrin/cholecystokinin type B receptor	RCA	21156802	PubMed	PTHR24243:SF45	GASTRIN/CHOLECYSTOKININ TYPE B RECEPTOR
P00036	Interleukin signaling pathway	P00983	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	12411479	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P02721	ATP synthesis	P02798	Cyt C	HUMAN|HGNC=19986|UniProtKB=P99999	Cytochrome c	RCA			PTHR11961:SF15	CYTOCHROME C
P00018	EGF receptor signaling pathway	P00543	ERK1-2	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00056	VEGF signaling pathway	P01425	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	11591316	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04393	Ras Pathway	P04553	PAK	BOVIN|Ensembl=ENSBTAG00000047856|UniProtKB=G3MZE2	Uncharacterized protein	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00054	Toll receptor signaling pathway	P01375	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00010	B cell activation	P00391	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00034	Integrin signalling pathway	P00944	Actin	BOVIN|Ensembl=ENSBTAG00000005714|UniProtKB=Q3ZC07	Actin, alpha cardiac muscle 1	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00029	Huntington disease	P00790	beta-Tubulin	CHICK|Ensembl=ENSGALG00000027684|UniProtKB=P09653	Tubulin beta-5 chain	TAS	9454836	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00010	B cell activation	P00367	NFAT	BOVIN|Ensembl=ENSBTAG00000018270|UniProtKB=F1MGR9	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IDA	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ORNAN|Ensembl=ENSOANG00000006175|UniProtKB=F7AZ85	Uncharacterized protein	ISS	9727008	PubMed	PTHR10410:SF5	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 14
P00057	Wnt signaling pathway	P01443	Phospholipase C	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	9860142	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00057	Wnt signaling pathway	P01457	GBeta	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	IDA	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00047	PDGF signaling pathway	P01145	c-fos	MACMU|Ensembl=ENSMMUG00000011291|UniProtKB=F6W9Y2	Uncharacterized protein	ISS			PTHR12565:SF11	UPSTREAM STIMULATORY FACTOR 2
P02772	Pyruvate metabolism	P03132	Pyruvate Kinase	MOUSE|MGI=MGI=97604|UniProtKB=P53657	Pyruvate kinase PKLR	RCA			PTHR11817:SF31	PYRUVATE KINASE PKLR
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02748	Isoleucine biosynthesis	P02995	Threonine dehydratase	YEAST|SGD=S000000888|UniProtKB=P00927	Threonine dehydratase, mitochondrial	ISS			PTHR43714:SF1	THREONINE DEHYDRATASE, MITOCHONDRIAL
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04393	Ras Pathway	P04557	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	IDA	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00807	Actin	DICPU|Gene=DICPUDRAFT_46519|UniProtKB=F0Z796	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00060	Ubiquitin proteasome pathway	P01490	E3	NEUCR|EnsemblGenome=EFNCRG00000003732|UniProtKB=Q7RV01	E3 ubiquitin-protein ligase	ISS			PTHR11254:SF67	E3 UBIQUITIN-PROTEIN LIGASE NEDD-4
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	XENTR|Ensembl=ENSXETG00000024231|UniProtKB=F6TCQ4	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	BOVIN|Ensembl=ENSBTAG00000011579|UniProtKB=F1N5C5	Muscarinic acetylcholine receptor	ISS	12915051	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	THEMA|EnsemblGenome=TM_0846|UniProtKB=Q9WZV0	Cytidine/deoxycytidine deaminase	ISS			PTHR11644:SF2	CYTIDINE DEAMINASE
P06959	CCKR signaling map	P07194	MAP2K1	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	RCA	9324163	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	LEIMA|EnsemblGenome=LmjF.18.1080|UniProtKB=Q27687	Protein kinase A catalytic subunit	IC	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00052	TGF-beta signaling pathway	P01275	P38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	TAS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PANTR|Ensembl=ENSPTRG00000018890|UniProtKB=Q5R1X3	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=1921305|UniProtKB=Q8K4S1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	12860966	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00005	Angiogenesis	P00203	Erk	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	9298898	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ORYSJ|EnsemblGenome=OS06G0154500|UniProtKB=Q84UI5	Mitogen-activated protein kinase 1	ISS	9836510	gi	PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P00018	EGF receptor signaling pathway	P00539	14-3-3	DANRE|ZFIN=ZDB-GENE-011115-1|UniProtKB=Q6PC29	14-3-3 protein gamma-1	ISS	9507245	gi	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00010	B cell activation	P00376	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IDA	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P00052	TGF-beta signaling pathway	P01275	P38	DANRE|ZFIN=ZDB-GENE-990415-257|UniProtKB=O42376	Mitogen-activated protein kinase 12	TAS	10851062	PubMed	PTHR24055:SF339	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00059	p53 pathway	P04610	Cyclin E	HUMAN|HGNC=1589|UniProtKB=P24864	G1/S-specific cyclin-E1	IPI	12729791	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	TAKRU|Ensembl=ENSTRUG00000007253|UniProtKB=H2SZQ1	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00029	Huntington disease	P00774	Dynein complex	ORYSJ|EnsemblGenome=OS01G0256400|UniProtKB=Q9SDK0	Os01g0256400 protein	IPI	9454836	PubMed	PTHR11886:SF35	DYNEIN LIGHT CHAIN 2, CYTOPLASMIC
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00256	PLC-gamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00049	Parkinson disease	P01222	Ubc6	DROME|FlyBase=FBgn0038515|UniProtKB=Q9VEJ4	CG5823, isoform A	TAS	12859888	PubMed	PTHR43972:SF1	UBIQUITIN-CONJUGATING ENZYME E2 J2
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	CAEEL|WormBase=WBGene00004960|UniProtKB=Q95PZ9	Serine/threonine-protein kinase spe-6	ISS	10617630	PubMed	PTHR11909:SF72	SERINE/THREONINE-PROTEIN KINASE SPE-6
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Ensembl=ENSPTRG00000017441|UniProtKB=H2QRU7	Glutamate receptor, ionotropic, AMPA 1	ISS	10331083	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00047	PDGF signaling pathway	P01150	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00030	Hypoxia response via HIF activation	P00821	Prolyl Hydroxylase	MACMU|Ensembl=ENSMMUG00000001197|UniProtKB=F7DAI9	Egl nine homolog 2	ISS	12912907	PubMed	PTHR12907:SF6	EGL NINE HOMOLOG 2
P00049	Parkinson disease	P01236	Casein kinase II	TAKRU|Ensembl=ENSTRUG00000016144|UniProtKB=H2UWE3	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00059	p53 pathway	P04635	Sumo-1 ligase	MOUSE|MGI=MGI=2158813|UniProtKB=P61957	Small ubiquitin-related modifier 2	ISS			PTHR10562:SF11	SMALL UBIQUITIN-RELATED MODIFIER 2-RELATED
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	HUMAN|HGNC=129|UniProtKB=P68133	Actin, alpha skeletal muscle	IEP	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00025	Hedgehog signaling pathway	P00699	Su(fu)	MOUSE|MGI=MGI=1345643|UniProtKB=Q9Z0P7	Suppressor of fused homolog	IDA	10920228	PubMed	PTHR10928:SF2	SUPPRESSOR OF FUSED HOMOLOG
P00018	EGF receptor signaling pathway	P00539	14-3-3	ARATH|TAIR=AT5G10450|UniProtKB=P48349	14-3-3-like protein GF14 lambda	NAS	10407019	PubMed	PTHR18860:SF27	14-3-3-LIKE PROTEIN GF14 LAMBDA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MOUSE|MGI=MGI=87889|UniProtKB=Q2MKA5	Neuronal acetylcholine receptor subunit alpha-5	IC	12388584	PubMed	PTHR18945:SF76	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	IC	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05731	GABA-B receptor II signaling	P05758	K channel	BOVIN|Ensembl=ENSBTAG00000006159|UniProtKB=E1BNE9	G protein-activated inward rectifier potassium channel 1	ISS	2433589	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00729	Goalpha	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	ISS	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01173	STAT	DANRE|ZFIN=ZDB-GENE-030820-2|UniProtKB=Q68SP3	Signal transducer and activator of transcription	ISS			PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00029	Huntington disease	P00790	beta-Tubulin	LEIMA|EnsemblGenome=LmjF.33.0792|UniProtKB=Q4Q4C4	Beta tubulin	TAS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P02727	Androgen/estrogene/progesterone biosynthesis	P02833	3beta-Hydroxysteroid dehydrogenase	MOUSE|MGI=MGI=96236|UniProtKB=Q61767	3 beta-hydroxysteroid dehydrogenase type 4	ISS	7491113	PubMed	PTHR10366:SF297	3 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 4-RELATED
P00047	PDGF signaling pathway	P01153	GSK3	MACMU|Ensembl=ENSMMUG00000014658|UniProtKB=F7FYS2	Uncharacterized protein	ISS			PTHR18905:SF11	NINEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	XENTR|Xenbase=XB-GENE-481480|UniProtKB=Q5XGI6	Casein kinase 1, epsilon	ISS	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	RAT|RGD=2342|UniProtKB=P08482	Muscarinic acetylcholine receptor M1	ISS	12181435	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P05918	p38 MAPK pathway	P06038	TRAF6	PANTR|Ensembl=ENSPTRG00000003510|UniProtKB=H2Q3F3	TNF receptor-associated factor 6	ISS			PTHR10131:SF111	TNF RECEPTOR-ASSOCIATED FACTOR 6
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00046	Oxidative stress response	P01129	JNK1/2	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00049	Parkinson disease	P01208	Hsp70	RAT|RGD=1311806|UniProtKB=P48721	Stress-70 protein, mitochondrial	IDA	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00037	Ionotropic glutamate receptor pathway	P01001	KA4	PANTR|Gene=GRIK4|UniProtKB=Q5IS46	Glutamate receptor ionotropic, kainate 4	ISS	12778120	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00022	General transcription by RNA polymerase I	P00650	TAF-IB	HUMAN|HGNC=11533|UniProtKB=Q53T94	TATA box-binding protein-associated factor RNA polymerase I subunit B	RCA			PTHR31576:SF2	TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	ARATH|TAIR=AT3G09360|UniProtKB=Q0WVQ3	Cyclin/Brf1-like TBP-binding protein	ISS			PTHR11618:SF4	TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT
P04393	Ras Pathway	P04544	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	8051109	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	MACMU|Ensembl=ENSMMUG00000014627|UniProtKB=F7GNE4	Catenin beta-1	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	PANTR|Ensembl=ENSPTRG00000000843|UniProtKB=H2QZN8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00014	Cholesterol biosynthesis	P00493	Geranyl trans-transferase	DROME|FlyBase=FBgn0025373|UniProtKB=Q7KN61	Farnesyl pyrophosphate synthase	ISS	O64905	SPACC	PTHR11525:SF0	FARNESYL PYROPHOSPHATE SYNTHASE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	TAS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00206	Wnt	CAEBR|Gene=CBG03422|UniProtKB=A8WV10	Protein CBR-CWN-2	ISS	11266476	PubMed	PTHR12027:SF77	PROTEIN WNT-5
P05734	Synaptic vesicle trafficking	P05773	Munc13	MOUSE|MGI=MGI=1917700|UniProtKB=B2RUP2	Protein unc-13 homolog D	ISS	608897	OMIM	PTHR10774:SF98	PROTEIN UNC-13 HOMOLOG D
P00021	FGF signaling pathway	P00644	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00011	Blood coagulation	P00456	HCII	RAT|RGD=619854|UniProtKB=Q64268	Heparin cofactor 2	ISS	13242285	gi	PTHR11461:SF30	HEPARIN COFACTOR 2
P00059	p53 pathway	P04616	PDK1/2	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	TAS	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00056	VEGF signaling pathway	P01425	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00019	Endothelin signaling pathway	P00577	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MOUSE|MGI=MGI=104558|UniProtKB=P18653	Ribosomal protein S6 kinase alpha-1	ISS	12213813	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	MOUSE|MGI=MGI=2150309|UniProtKB=Q4VA61	Down syndrome cell adhesion molecule-like protein 1 homolog	ISS			PTHR44107:SF3	DOWN SYNDROME CELL ADHESION MOLECULE-LIKE PROTEIN 1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00539	14-3-3	ENTHI|EnsemblGenome=EHI_006810|UniProtKB=C4M0F4	14-3-3 protein 3	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00010	B cell activation	P00391	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	XENTR|Xenbase=XB-GENE-5923225|UniProtKB=F6RVZ6	Glutamine synthetase (Fragment)	ISS			PTHR20852:SF43	GLUTAMINE SYNTHETASE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00049	Parkinson disease	P01211	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01433	SIAH-1	RAT|RGD=620778|UniProtKB=Q8R4T2	E3 ubiquitin-protein ligase SIAH2	ISS			PTHR10315:SF11	E3 UBIQUITIN-PROTEIN LIGASE SIAH2
P00021	FGF signaling pathway	P00633	Ras	BOVIN|Ensembl=ENSBTAG00000009778|UniProtKB=E1BMX0	Uncharacterized protein	ISS	99084794	PubMed	PTHR24070:SF186	GTPASE KRAS
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000024992|UniProtKB=F6TUR3	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	MACMU|Ensembl=ENSMMUG00000003236|UniProtKB=F7DNS6	Uncharacterized protein	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	YEAST|SGD=S000002634|UniProtKB=P07170	Adenylate kinase	ISS			PTHR23359:SF117	ADENYLATE KINASE 2, MITOCHONDRIAL
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00034	Integrin signalling pathway	P00948	Rho	CHICK|Ensembl=ENSGALG00000003806|UniProtKB=O93467	GTP-binding protein	ISS	12039949	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	HUMAN|HGNC=6266|UniProtKB=P48544	G protein-activated inward rectifier potassium channel 4	IDA			PTHR11767:SF52	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 4
P00005	Angiogenesis	P00204	PLD	MOUSE|MGI=MGI=109585|UniProtKB=Q9Z280	Phospholipase D1	ISS	9307024	PubMed	PTHR18896:SF57	PHOSPHOLIPASE D1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MACMU|Ensembl=ENSMMUG00000009287|UniProtKB=F7H3T9	Glutamate receptor 1 isoform 1	ISS	10331083	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00019	Endothelin signaling pathway	P00568	PKC	CANAL|CGD=CAL0003231|UniProtKB=Q5ANK2	Protein kinase C	IGI	11554554	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IGI	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=12774|UniProtKB=P04628	Proto-oncogene Wnt-1	IDA	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00029	Huntington disease	P00805	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02783	Tryptophan biosynthesis	P03208	Tryptophan synthase B	STRCO|EnsemblGenome=CAB51429|UniProtKB=O05625	Tryptophan synthase beta chain	ISS			PTHR42882:SF1	TRYPTOPHAN SYNTHASE
P00021	FGF signaling pathway	P00641	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=19663|UniProtKB=Q9UBI6	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	DROME|FlyBase=FBgn0019947|UniProtKB=O02194	Presenilin homolog	TAS	12369105	PubMed	PTHR10202:SF13	PRESENILIN-2
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	MACMU|Ensembl=ENSMMUG00000015828|UniProtKB=F7CE90	Recombining binding protein suppressor of hairless isoform 4	ISS	15187023	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00047	PDGF signaling pathway	P01154	Ras	CRYNJ|EnsemblGenome=CNA02810|UniProtKB=P0CQ42	Ras-like protein	ISS	7997267	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00052	TGF-beta signaling pathway	P01284	JNK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00010	B cell activation	P00397	IKK	CANLF|Ensembl=ENSCAFG00000005526|UniProtKB=E2RKR0	Uncharacterized protein	ISS	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00057	Wnt signaling pathway	P01435	SWI/SNF	HUMAN|HGNC=11958|UniProtKB=Q96L91	E1A-binding protein p400	IDA	11532957	PubMed	PTHR10799:SF599	E1A-BINDING PROTEIN P400
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02913	Thymidylate synthase	CAEEL|WormBase=WBGene00022455|UniProtKB=Q9N588	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00053	T cell activation	P01306	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00020	FAS signaling pathway	P00615	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00385	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	TAS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MOUSE|MGI=MGI=1336171|UniProtKB=Q9DAS9	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IDA	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P02786	Vitamin B6 biosynthesis	P03225	1-Deoxyxylulose-5-phosphate synthase	DEIRA|EnsemblGenome=DR_1475|UniProtKB=Q9RUB5	1-deoxy-D-xylulose-5-phosphate synthase	ISS			PTHR43322:SF5	1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE 1-RELATED
P04393	Ras Pathway	P04567	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00046	Oxidative stress response	P01124	Myc	MOUSE|MGI=MGI=97250|UniProtKB=P01108	Myc proto-oncogene protein	TAS	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00012	Cadherin signaling pathway	P00470	F-actin	ARATH|TAIR=AT5G59370|UniProtKB=P53494	Actin-4	IC	10974003	PubMed	PTHR11937:SF366	ACTIN-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	PANTR|Ensembl=ENSPTRG00000001202|UniProtKB=H2PZT8	Uncharacterized protein	ISS	1333052	PubMed	PTHR24241:SF116	GONADOTROPIN-RELEASING HORMONE II RECEPTOR-RELATED
P00018	EGF receptor signaling pathway	P00562	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	CHICK|Ensembl=ENSGALG00000011699|UniProtKB=F1NEC3	Uncharacterized protein	IDA	2491850	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P04393	Ras Pathway	P04572	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IGI	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04393	Ras Pathway	P04547	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	BOVIN|Ensembl=ENSBTAG00000043994|UniProtKB=E1BP29	Protein-serine/threonine kinase	ISS	12032308	PubMed	PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CAEEL|WormBase=WBGene00001187|UniProtKB=Q8MQA1	Uncharacterized protein	IC	8838325	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00023	General transcription regulation	P00658	TBP-associated factors	DANRE|ZFIN=ZDB-GENE-040426-1013|UniProtKB=Q6P0T2	Transcription initiation factor TFIID subunit 8	ISS	604904	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P02752	Mannose metabolism	P03019	P-Mannose mutase	RAT|RGD=1310897|UniProtKB=Q5RK25	Phosphomannomutase	ISS	11042159	PubMed	PTHR10466:SF1	PHOSPHOMANNOMUTASE 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	HUMAN|HGNC=4583|UniProtKB=Q16478	Glutamate receptor ionotropic, kainate 5	ISS	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00029	Huntington disease	P00790	beta-Tubulin	EMENI|EnsemblGenome=CADANIAG00007636|UniProtKB=P10874	Tubulin beta-2 chain	TAS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	XENTR|GeneID=394982|UniProtKB=P20399	Actin, alpha cardiac muscle 2	ISS	11889139	PubMed	PTHR11937:SF263	ACTIN
P00018	EGF receptor signaling pathway	P00558	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00059	p53 pathway	P01486	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00046	Oxidative stress response	P01138	MKK4	CANLF|Ensembl=ENSCAFG00000017851|UniProtKB=F1PBB6	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00272	ASK1	PANTR|Ensembl=ENSPTRG00000024326|UniProtKB=H2R231	Uncharacterized protein	ISS	12697749	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00006	Apoptosis signaling pathway	P00321	HSP70	YEAST|SGD=S000000004|UniProtKB=P10591	Heat shock protein SSA1	ISS	12150907	PubMed	PTHR19375:SF309	HEAT SHOCK PROTEIN SSA1-RELATED
P04393	Ras Pathway	P04572	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00019	Endothelin signaling pathway	P00566	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00629	PP2A	MOUSE|MGI=MGI=1289252|UniProtKB=Q925E7	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform	ISS			PTHR11871:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B DELTA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04495	TSC1	RAT|RGD=620124|UniProtKB=Q9Z136	Hamartin	ISS	12820960	PubMed	PTHR15154:SF2	HAMARTIN
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00021	FGF signaling pathway	P00629	PP2A	RAT|RGD=708356|UniProtKB=P56932	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform	ISS			PTHR11871:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B DELTA ISOFORM
P00049	Parkinson disease	P01238	14-3-3	MOUSE|MGI=MGI=109484|UniProtKB=P63101	14-3-3 protein zeta/delta	ISS	92362864	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00006	Apoptosis signaling pathway	P00318	PKCs	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00053	T cell activation	P01307	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IDA	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	ISS	19114921	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	RCA			PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00029	Huntington disease	P00776	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	11840290	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00057	Wnt signaling pathway	P01447	Dishevelled	HUMAN|HGNC=3084|UniProtKB=O14640	Segment polarity protein dishevelled homolog DVL-1	ISS	11212302	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P05918	p38 MAPK pathway	P06020	p38delta	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	RCA	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00034	Integrin signalling pathway	P00925	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	XENTR|Xenbase=XB-GENE-6258657|UniProtKB=F6WX39	Uncharacterized protein (Fragment)	ISS	12488551	PubMed	PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	TAS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00029	Huntington disease	P00780	Microtubule	RAT|RGD=1309427|UniProtKB=Q3KRE8	Tubulin beta-2B chain	IDA	12932731	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P06664	Gonadotropin-releasing hormone receptor pathway	P06834	MAP3Ks	MOUSE|MGI=MGI=1346876|UniProtKB=O35099	Mitogen-activated protein kinase kinase kinase 5	RCA	8974401	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_114958|UniProtKB=C3XZ13	Putative uncharacterized protein	ISS			PTHR11937:SF359	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	CHICK|Ensembl=ENSGALG00000015358|UniProtKB=F1NM49	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF575	MYOSIN-15
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00049	Parkinson disease	P01211	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00402	Jnk	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05731	GABA-B receptor II signaling	P05754	Ggamma	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P02762	Pentose phosphate pathway	P03079	Hexokinase	MACMU|Ensembl=ENSMMUG00000015302|UniProtKB=F6Q724	Uncharacterized protein	RCA			PTHR19443:SF10	HEXOKINASE-1
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	DROME|FlyBase=FBgn0000253|UniProtKB=P62152	Calmodulin	ISS	3885394	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	DANRE|ZFIN=ZDB-GENE-000330-9|UniProtKB=Q90ZE4	Presenilin-2	IDA	12424519	PubMed	PTHR10202:SF13	PRESENILIN-2
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00018	EGF receptor signaling pathway	P00551	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01407	Erk	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00750	Rhodopsin kinase	BOVIN|Ensembl=ENSBTAG00000019963|UniProtKB=P28327	Rhodopsin kinase	IDA	8260489	PubMed	PTHR24355:SF11	RHODOPSIN KINASE
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	ARATH|TAIR=AT3G59760|UniProtKB=Q43725	Cysteine synthase, mitochondrial	ISS			PTHR10314:SF131	CYSTEINE SYNTHASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	12488551	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	HUMAN|HGNC=4600|UniProtKB=O00222	Metabotropic glutamate receptor 8	IDA			PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00019	Endothelin signaling pathway	P00589	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	RAT|RGD=61863|UniProtKB=P19493	Glutamate receptor 4	ISS	12871085	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00025	Hedgehog signaling pathway	P00682	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00949	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	7798194	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00898	FKHR	PANTR|Ensembl=ENSPTRG00000018476|UniProtKB=H2R710	Forkhead box O3	ISS	12884295	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00005	Angiogenesis	P00189	Fzd	MACMU|Ensembl=ENSMMUG00000007486|UniProtKB=F6QL95	Frizzled-3	ISS	8717036	PubMed	PTHR11309:SF22	FRIZZLED-3
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	XENTR|Ensembl=ENSXETG00000030140|UniProtKB=F7EP58	Uncharacterized protein (Fragment)	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00029	Huntington disease	P00790	beta-Tubulin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g245773|UniProtKB=A7SJX9	Predicted protein	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95818|UniProtKB=Q61626	Glutamate receptor ionotropic, kainate 5	ISS	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00049	Parkinson disease	P01227	20S proteasome	CAEBR|Gene=CBG02289|UniProtKB=A8WUP0	Proteasome subunit beta type	ISS	12859888	PubMed	PTHR11599:SF62	PROTEASOME SUBUNIT BETA TYPE-3
P00018	EGF receptor signaling pathway	P00564	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P04398	p53 pathway feedback loops 2	P04651	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00006	Apoptosis signaling pathway	P00279	endoG	MOUSE|MGI=MGI=1261433|UniProtKB=O08600	Endonuclease G, mitochondrial	ISS	9324313	PubMed	PTHR13966:SF5	ENDONUCLEASE G, MITOCHONDRIAL
P00056	VEGF signaling pathway	P01423	p38MAPK	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00049	Parkinson disease	P01211	ERK	YEAST|SGD=S000003272|UniProtKB=P14681	Mitogen-activated protein kinase KSS1	IDA			PTHR24055:SF338	MITOGEN-ACTIVATED PROTEIN KINASE KSS1
P04393	Ras Pathway	P04569	Cdc42	PRIPA|Gene=PPA22610|UniProtKB=H3FK05	Uncharacterized protein	ISS	11412997	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00056	VEGF signaling pathway	P01414	PLC-gamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	8170357	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00053	T cell activation	P01333	cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	PANTR|Ensembl=ENSPTRG00000002979|UniProtKB=H2Q2M8	Uncharacterized protein	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00019	Endothelin signaling pathway	P00589	Akt	CAEEL|WormBase=WBGene00000103|UniProtKB=Q9XTG7	Serine/threonine-protein kinase akt-2	ISS	12089061	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01129	JNK1/2	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00010	B cell activation	P00371	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00807	Actin	HUMAN|HGNC=130|UniProtKB=P62736	Actin, aortic smooth muscle	IDA	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00025	Hedgehog signaling pathway	P00682	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000013632|UniProtKB=E1B965	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P02755	Methylmalonyl pathway	P03033	Propionyl-CoA carboxylase	MACMU|Ensembl=ENSMMUG00000004493|UniProtKB=F7HD53	Uncharacterized protein	ISS			PTHR18866:SF104	PROPIONYL-COA CARBOXYLASE ALPHA CHAIN, MITOCHONDRIAL
P00018	EGF receptor signaling pathway	P00558	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04384	Gamma-aminobutyric acid synthesis	P04482	Glutamate decarboxylase	CIOIN|Ensembl=ENSCING00000001989|UniProtKB=F6XG08	Uncharacterized protein	ISS	2247446	PubMed	PTHR11999:SF137	GLUTAMATE DECARBOXYLASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	YEAST|SGD=S000001855|UniProtKB=P60010	Actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04393	Ras Pathway	P04559	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	4757952	gi	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_127490|UniProtKB=C3XYC5	Putative uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=18539|UniProtKB=P61266	Syntaxin-1B	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	IC	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00018	EGF receptor signaling pathway	P00564	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04393	Ras Pathway	P04565	MKK4/7	HUMAN|HGNC=6844|UniProtKB=P45985	Dual specificity mitogen-activated protein kinase kinase 4	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00015	Circadian clock system	G01497	cry	MONDO|Ensembl=ENSMODG00000001579|UniProtKB=F7BWW8	Uncharacterized protein	ISS	10428031	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00056	VEGF signaling pathway	P01414	PLC-gamma	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00060	Ubiquitin proteasome pathway	P01491	E2	ORYSJ|EnsemblGenome=OS01G0658400|UniProtKB=Q8S920	Ubiquitin-conjugating enzyme E2 5A	ISS			PTHR24068:SF122	SUBFAMILY NOT NAMED
P00009	Axon guidance mediated by netrin	P00363	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	BOVIN|Ensembl=ENSBTAG00000000231|UniProtKB=F1MCE7	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	HUMAN|HGNC=5960|UniProtKB=O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	CANLF|Ensembl=ENSCAFG00000032530|UniProtKB=J9P2I5	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF155	REGULATOR OF G-PROTEIN SIGNALING 18
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	CRYNJ|EnsemblGenome=CNA02810|UniProtKB=P0CQ42	Ras-like protein	ISS	7997267	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00036	Interleukin signaling pathway	P00965	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01148	Grb2	MACMU|Ensembl=ENSMMUG00000005327|UniProtKB=F7GJG7	GRB2-related adapter protein	ISS	8647802	PubMed	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P00049	Parkinson disease	P01235	Fyn kinase	DANRE|ZFIN=ZDB-GENE-050706-89|UniProtKB=F1RDG9	Tyrosine-protein kinase fynb	ISS	11078745	PubMed	PTHR24418:SF242	TYROSINE-PROTEIN KINASE FYNB
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	RCA	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00029	Huntington disease	P00799	JNK-2	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	RAT|RGD=2500|UniProtKB=Q920D2	Dihydrofolate reductase	ISS			PTHR22778:SF16	DIHYDROFOLATE REDUCTASE
P02747	Histidine biosynthesis	P02992	Imidazol glycerol phosphate synthase	BACSU|EnsemblGenome=BSU34870|UniProtKB=O34727	Imidazole glycerol phosphate synthase subunit HisF	ISS			PTHR21235:SF2	IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF
P00029	Huntington disease	P00811	Arp2/3 complex	CHICK|Ensembl=ENSGALG00000004693|UniProtKB=Q5ZJI7	Uncharacterized protein	ISS	12473693	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PHYPA|Gene=PHYPADRAFT_109052|UniProtKB=A9TZ58	Actin 5	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	TAS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	PANTR|Ensembl=ENSPTRG00000006510|UniProtKB=H2Q8K1	Presenilin	ISS	12736250	PubMed	PTHR10202:SF18	PRESENILIN-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00018	EGF receptor signaling pathway	P00547	PP2A	CANLF|Ensembl=ENSCAFG00000015787|UniProtKB=F6V7D9	Uncharacterized protein	ISS	8703017	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P02775	Salvage pyrimidine ribonucleotides	P03151	Uracil phosphoribosyl  transferase	SULSO|EnsemblGenome=SSO0231|UniProtKB=Q980Q4	Uracil phosphoribosyltransferase	ISS			PTHR10285:SF46	URACIL PHOSPHORIBOSYLTRANSFERASE, CHLOROPLASTIC
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=107433|UniProtKB=P70407	Cadherin-9	ISS	8120095	PubMed	PTHR24027:SF99	CADHERIN-9
P00053	T cell activation	P01319	PAK	PANTR|Ensembl=ENSPTRG00000022187|UniProtKB=Q7YQL4	Serine/threonine-protein kinase PAK 3	ISS	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00019	Endothelin signaling pathway	P00586	Gq	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01188	Gbetagamma	PANTR|Ensembl=ENSPTRG00000007084|UniProtKB=H2Q9G5	Uncharacterized protein	ISS	10051575	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	TAS	2837282	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P02775	Salvage pyrimidine ribonucleotides	P03153	Cytidylate kinase	ANOGA|EnsemblGenome=AGAP003968|UniProtKB=Q7Q292	UMP-CMP kinase	ISS			PTHR23359:SF107	UMP-CMP KINASE
P00005	Angiogenesis	P00255	Notch	PANTR|Ensembl=ENSPTRG00000034379|UniProtKB=H2RDK4	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P00006	Apoptosis signaling pathway	P00269	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00035	Interferon-gamma signaling pathway	P00956	SOCS	MOUSE|MGI=MGI=3642840|UniProtKB=D3Z193	MCG128463	ISS	15032587	PubMed	PTHR44396:SF2	SUPPRESSOR OF CYTOKINE SIGNALING 2
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	20331588	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00023	General transcription regulation	P00658	TBP-associated factors	HUMAN|HGNC=11541|UniProtKB=Q15545	Transcription initiation factor TFIID subunit 7	ISS			PTHR12228:SF6	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 7
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	DANRE|ZFIN=ZDB-GENE-040808-67|UniProtKB=Q6AZA4	K-ras	ISS	10825661	PubMed	PTHR24070:SF186	GTPASE KRAS
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	RCA	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00006	Apoptosis signaling pathway	P00302	ATF	MOUSE|MGI=MGI=109349|UniProtKB=P16951	Cyclic AMP-dependent transcription factor ATF-2	ISS	11390664	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	IDA	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IC	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00052	TGF-beta signaling pathway	P01284	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05918	p38 MAPK pathway	P06029	p38beta	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	RCA	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00059	p53 pathway	P04630	PP2A	BRAFL|Gene=BRAFLDRAFT_123893|UniProtKB=C3XQF4	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04564	MAPKAP	BOVIN|Ensembl=ENSBTAG00000016532|UniProtKB=Q3SYZ2	MAP kinase-activated protein kinase 3	ISS	11157753	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	G04671	proopiomelanocortin	MONDO|Ensembl=ENSMODG00000015853|UniProtKB=Q95J84	Proopiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	RAT|RGD=1309750|UniProtKB=D4A7X9	Myosin IF (Predicted)	ISS			PTHR13140:SF288	UNCONVENTIONAL MYOSIN-IF
P00049	Parkinson disease	P01207	PLD2	MOUSE|MGI=MGI=892877|UniProtKB=P97813	Phospholipase D2	IDA	15030398	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04393	Ras Pathway	P04541	p90RSK	MOUSE|MGI=MGI=1342290|UniProtKB=Q9WUT3	Ribosomal protein S6 kinase alpha-2	IDA	15526037	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00045	Notch signaling pathway	P01104	Serrate	MONDO|Ensembl=ENSMODG00000004910|UniProtKB=F7C1Q4	Delta-like protein	ISS	8631496	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MOUSE|MGI=MGI=102705|UniProtKB=P63213	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00056	VEGF signaling pathway	P01411	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P00021	FGF signaling pathway	P00644	p38	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	IGI	10995439	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00565	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IGI	2837282	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	DROME|FlyBase=FBgn0004852|UniProtKB=Q9VW60	Adenylate cyclase type 2	ISS			PTHR11920:SF352	ADENYLATE CYCLASE TYPE 2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	11832947	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00029	Huntington disease	P00790	beta-Tubulin	ORNAN|Ensembl=ENSOANG00000004797|UniProtKB=F7FFR0	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P00006	Apoptosis signaling pathway	P00260	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	YEAST|SGD=S000001328|UniProtKB=P21672	Ribonucleoside-diphosphate reductase large chain 2	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00021	FGF signaling pathway	P00626	Spry	MACMU|Ensembl=ENSMMUG00000014175|UniProtKB=F7ALK4	Uncharacterized protein	ISS	22024232	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	TAKRU|Ensembl=ENSTRUG00000016241|UniProtKB=H2UX35	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF305	PROTEIN KINASE C
P02778	Sulfate assimilation	P03167	Sulfate adenylyltransferase	DEIRA|EnsemblGenome=DR_A0016|UniProtKB=P56864	Sulfate adenylyltransferase	ISS			PTHR43509:SF1	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00059	p53 pathway	G04700	PAI	RAT|RGD=3249|UniProtKB=P20961	Plasminogen activator inhibitor 1	ISS	6981332	gi	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00045	Notch signaling pathway	P01107	Fringe	HUMAN|HGNC=6560|UniProtKB=Q8NES3	Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe	ISS			PTHR10811:SF7	BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE LUNATIC FRINGE
P00005	Angiogenesis	P00204	PLD	PANTR|Ensembl=ENSPTRG00000008610|UniProtKB=H2QBY9	Uncharacterized protein	ISS	15030398	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P00050	Plasminogen activating cascade	P01256	uPAR	HUMAN|HGNC=9053|UniProtKB=Q03405	Urokinase plasminogen activator surface receptor	IEA	11875699	gi	PTHR10624:SF6	UROKINASE PLASMINOGEN ACTIVATOR SURFACE RECEPTOR
P00059	p53 pathway	G04702	p53	BOVIN|Ensembl=ENSBTAG00000001069|UniProtKB=P67939	Cellular tumor antigen p53	TAS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	HUMAN|HGNC=4587|UniProtKB=Q14957	Glutamate receptor ionotropic, NMDA 2C	IC	11319238	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P05730	Endogenous cannabinoid signaling	P05751	Galpha	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	TAKRU|Ensembl=ENSTRUG00000009259|UniProtKB=H2TF39	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00006	Apoptosis signaling pathway	P00318	PKCs	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00005	Angiogenesis	P00203	Erk	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00015	Circadian clock system	G01501	cry	MOUSE|MGI=MGI=1270841|UniProtKB=P97784	Cryptochrome-1	IDA	10217146	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	DICDI|dictyBase=DDB_G0279413|UniProtKB=P05987	cAMP-dependent protein kinase regulatory subunit	ISS	91298951	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	YEAST|SGD=S000006189|UniProtKB=P32383	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1	TAS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BOVIN|Ensembl=ENSBTAG00000006189|UniProtKB=P63258	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P05918	p38 MAPK pathway	P06025	SRF	BOVIN|Ensembl=ENSBTAG00000012777|UniProtKB=E1BJP4	Uncharacterized protein	ISS	15647354	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	12805548	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00575	furin	XENTR|Xenbase=XB-GENE-999035|UniProtKB=F7CEB1	Uncharacterized protein	ISS	10956649	PubMed	PTHR42884:SF1	FURIN
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00167	CD44 transmembrane fragment	RAT|RGD=2307|UniProtKB=P26051	CD44 antigen	IDA	12223485	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P06664	Gonadotropin-releasing hormone receptor pathway	P06786	ERK1/2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	RCA	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00091	Aph-1	CAEEL|WormBase=WBGene00000147|UniProtKB=O45876	Gamma-secretase subunit aph-1	IDA	12471034	PubMed	PTHR12889:SF0	GAMMA-SECRETASE SUBUNIT APH-1
P00006	Apoptosis signaling pathway	P00260	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00799	JNK-2	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00036	Interleukin signaling pathway	P00973	PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00053	T cell activation	P01305	Calmodulin	HUMAN|HGNC=1442|UniProtKB=P62158	Calmodulin	IDA	3885394	PubMed	PTHR23050:SF311	CALMODULIN
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=15983|UniProtKB=P56704	Protein Wnt-3a	TAS	8717036	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	PANTR|Ensembl=ENSPTRG00000004090|UniProtKB=H2Q4F7	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	MOUSE|MGI=MGI=105367|UniProtKB=P16382	Interleukin-4 receptor subunit alpha	IDA	2805066	PubMed	PTHR23037:SF32	INTERLEUKIN-4 RECEPTOR SUBUNIT ALPHA
P04396	Vitamin D metabolism and pathway	P04607	FDX	ANOGA|EnsemblGenome=AGAP003212|UniProtKB=Q7QBE1	AGAP003212-PA	IDA	2969697	PubMed	PTHR23426:SF25	FERREDOXIN 2
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05913	Enkephalin release	P05971	CREB	RAT|RGD=2402|UniProtKB=Q03061	cAMP-responsive element modulator	ISS			PTHR22952:SF97	CAMP-RESPONSIVE ELEMENT MODULATOR
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00010	B cell activation	P00391	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05916	Opioid prodynorphin pathway	P06000	vasopressin	HUMAN|HGNC=8528|UniProtKB=P01178	Oxytocin-neurophysin 1	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	BOVIN|Ensembl=ENSBTAG00000009245|UniProtKB=Q0P594	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01472	Histone deacetylase	TRYB2|Gene=Tb10.70.6220|UniProtKB=Q38C74	Histone deacetylase	ISS	10485845	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00030	Hypoxia response via HIF activation	P00819	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04611	P300	PANTR|Ensembl=ENSPTRG00000014418|UniProtKB=H2QLS0	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00006	Apoptosis signaling pathway	P00318	PKCs	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DANRE|ZFIN=ZDB-GENE-040718-93|UniProtKB=Q6DGZ5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00059	p53 pathway	G04694	p110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00060	Ubiquitin proteasome pathway	P01491	E2	PANTR|Ensembl=ENSPTRG00000013564|UniProtKB=H2QKH0	Ubiquitin-conjugating enzyme E2C	ISS			PTHR44189:SF1	UBIQUITIN-CONJUGATING ENZYME E2 C
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00049	Parkinson disease	P01211	ERK	MOUSE|MGI=MGI=2652894|UniProtKB=Q80Y86	Mitogen-activated protein kinase 15	ISS	10851062	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IC	15572354	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00056	VEGF signaling pathway	P01414	PLC-gamma	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00046	Oxidative stress response	P01138	MKK4	CHICK|Ensembl=ENSGALG00000001001|UniProtKB=F1P3T1	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00021	FGF signaling pathway	P00640	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00045	Notch signaling pathway	P01099	Notch	MACMU|Ensembl=ENSMMUG00000018375|UniProtKB=F7H1D5	Neurogenic locus notch homolog protein 2 isoform 1 preproprotein	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01430	p53	BOVIN|Ensembl=ENSBTAG00000001069|UniProtKB=P67939	Cellular tumor antigen p53	IDA	14744434	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	BOVIN|Ensembl=ENSBTAG00000009778|UniProtKB=E1BMX0	Uncharacterized protein	ISS	3023884	PubMed	PTHR24070:SF186	GTPASE KRAS
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00048	PI3 kinase pathway	P01182	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04570	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04635	Sumo-1 ligase	DANRE|ZFIN=ZDB-GENE-040426-2133|UniProtKB=Q6NV25	Small ubiquitin-related modifier 3-like	ISS			PTHR10562:SF50	SMALL UBIQUITIN-RELATED MODIFIER 3
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	PSEAE|EnsemblGenome=PA0870|UniProtKB=P43336	Aromatic-amino-acid aminotransferase	ISS			PTHR11879:SF11	ASPARTATE AMINOTRANSFERASE
P00054	Toll receptor signaling pathway	P01345	IKKalpha	PANTR|Ensembl=ENSPTRG00000033948|UniProtKB=H2RBD4	Conserved helix-loop-helix ubiquitous kinase	ISS	14499113	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00038	JAK/STAT signaling pathway	P01027	STAT	RAT|RGD=1309063|UniProtKB=Q1KQ07	Signal transducer and activator of transcription	ISS	14598258	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00018	EGF receptor signaling pathway	P00543	ERK1-2	YEAST|SGD=S000001644|UniProtKB=P36005	Serine/threonine-protein kinase KDX1	ISS			PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P00010	B cell activation	P00391	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01095	beta	MOUSE|MGI=MGI=87892|UniProtKB=Q8R493	Neuronal acetylcholine receptor subunit beta-4	ISS	22213672	PubMed	PTHR18945:SF385	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-4
P00005	Angiogenesis	P00243	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P06002	G-protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01413	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	14526383	PubMed	PTHR10048:SF14	PI-3 KINASE
P04393	Ras Pathway	P04553	PAK	MOUSE|MGI=MGI=1339975|UniProtKB=O88643	Serine/threonine-protein kinase PAK 1	IDA	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00052	TGF-beta signaling pathway	P01292	RSmads	DANRE|ZFIN=ZDB-GENE-030128-4|UniProtKB=Q66HX9	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF48	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	CAEEL|WormBase=WBGene00000109|UniProtKB=G5ECV9	10-formyltetrahydrofolate dehydrogenase	IC			PTHR11699:SF190	10-FORMYLTETRAHYDROFOLATE DEHYDROGENASE
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IDA	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MOUSE|MGI=MGI=1339709|UniProtKB=P13541	Myosin-3	ISS	89264452	PubMed	PTHR13140:SF427	MYOSIN-3
P00004	Alzheimer disease-presenilin pathway	P00163	Erb-B4 C-terminal fragment	MONDO|Ensembl=ENSMODG00000015755|UniProtKB=F6ZSZ9	Uncharacterized protein (Fragment)	ISS	4884676	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P02725	Allantoin degradation	P02821	Allantoate amidohydrolase	YEAST|SGD=S000001468|UniProtKB=P25335	Allantoicase	ISS			PTHR12045:SF3	ALLANTOICASE-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00054	Toll receptor signaling pathway	P01360	IKKbeta	RAT|RGD=621375|UniProtKB=Q9QY78	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04572	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00025	Hedgehog signaling pathway	P00682	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00236	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00029	Huntington disease	P00786	ARF	CANAL|CGD=CAL0003401|UniProtKB=Q5AND9	ADP-ribosylation factor 1	ISS	11752622	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P05915	Opioid proenkephalin pathway	P05994	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00005	Angiogenesis	P00243	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00011	Blood coagulation	P00415	Plasmin	MACMU|Gene=PLG|UniProtKB=P12545	Plasminogen	ISS	4505881	gi	PTHR24261:SF6	PLASMINOGEN
P00029	Huntington disease	P00794	Hippi	MACMU|Ensembl=ENSMMUG00000008786|UniProtKB=F7F6A6	Intraflagellar transport protein 57 homolog	ISS	11788820	PubMed	PTHR16011:SF0	INTRAFLAGELLAR TRANSPORT PROTEIN 57 HOMOLOG
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IC	10747026	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IDA	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P05731	GABA-B receptor II signaling	P05754	Ggamma	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	1171954	gi	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04393	Ras Pathway	P04552	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CHICK|Ensembl=ENSGALG00000012511|UniProtKB=F1NCH1	Uncharacterized protein	ISS			PTHR11824:SF7	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04674	Mdm2	BOVIN|Ensembl=ENSBTAG00000010422|UniProtKB=F1MYE6	Uncharacterized protein	ISS	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00049	Parkinson disease	P01234	GRK	DROME|FlyBase=FBgn0260798|UniProtKB=P32865	G protein-coupled receptor kinase 1	IDA	8260489	PubMed	PTHR24355:SF18	PROTEIN-SERINE/THREONINE KINASE
P02738	De novo purine biosynthesis	P02898	Phosphoribosylformylglycinamide  synthase	SCHPO|PomBase=SPAC6F12.10c|UniProtKB=O14228	Probable phosphoribosylformylglycinamidine synthase	ISS			PTHR10099:SF1	PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DANRE|ZFIN=ZDB-GENE-030131-172|UniProtKB=Q6IQR3	Actin, alpha, cardiac muscle 1a	ISS	11889126	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CAEEL|WormBase=WBGene00004036|UniProtKB=G5EFI8	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P05913	Enkephalin release	P05974	G-Protein (i)	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00021	FGF signaling pathway	P00624	14-3-3	CHICK|Ensembl=ENSGALG00000004143|UniProtKB=Q5ZLQ6	14-3-3 protein beta/alpha	ISS	10407019	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	HUMAN|HGNC=6855|UniProtKB=Q99759	Mitogen-activated protein kinase kinase kinase 3	IGI	9006902	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00627	ERK1-2	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	12846562	PubMed	PTHR10202:SF13	PRESENILIN-2
P05918	p38 MAPK pathway	P06015	p38gamma	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	RCA	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00053	T cell activation	P01320	PLC-gamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	HUMAN|HGNC=6407|UniProtKB=P01116	GTPase KRas	ISS	6287573	PubMed	PTHR24070:SF186	GTPASE KRAS
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00205	GAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	2842690	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04398	p53 pathway feedback loops 2	P04661	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01194	S6K	PANTR|Ensembl=ENSPTRG00000009477|UniProtKB=H2QDK7	Ribosomal protein S6 kinase	ISS	11861821	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P02747	Histidine biosynthesis	P02988	Histidinal dehydrogenase	SCHPO|PomBase=SPBC1711.13|UniProtKB=Q9P777	Histidinol dehydrogenase	ISS			PTHR21256:SF2	HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN
P04393	Ras Pathway	P04566	Stat 1/3	BOVIN|Gene=STAT3|UniProtKB=P61635	Signal transducer and activator of transcription 3	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CANLF|Ensembl=ENSCAFG00000016020|UniProtKB=O18840	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04393	Ras Pathway	P04547	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	91232861	PubMed	PTHR24070:SF385	GTPASE HRAS
P00005	Angiogenesis	P00220	c-Jun	CHICK|Gene=JUN|UniProtKB=P18870	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00010	B cell activation	P00381	Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	IGI	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00019	Endothelin signaling pathway	P00590	IP3 R	CAEEL|WormBase=WBGene00002173|UniProtKB=Q9Y0A1	Inositol 1,4,5-trisphosphate receptor itr-1	ISS	12880387	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00021	FGF signaling pathway	P00640	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00021	FGF signaling pathway	P00642	MEK1-2	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	MACMU|Ensembl=ENSMMUG00000021796|UniProtKB=F7ET64	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF74	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA
P05913	Enkephalin release	P05972	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00009	Axon guidance mediated by netrin	P00357	Netrin	DROME|FlyBase=FBgn0015773|UniProtKB=Q24567	Netrin-A	ISS			PTHR10574:SF365	NETRIN-1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	TAS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01396	TFIIFbeta	SCHPO|PomBase=SPBC1198.13c|UniProtKB=O94424	Transcription initiation factor IIF subunit beta	ISS			PTHR10445:SF0	GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2
P02749	Leucine biosynthesis	P02999	2-Isopropylmalate synthase	METAC|EnsemblGenome=MA_3793|UniProtKB=Q8TJJ1	Putative (R)-citramalate synthase CimA	ISS			PTHR42880:SF1	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00551	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PANTR|Ensembl=ENSPTRG00000009762|UniProtKB=H2QE24	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00045	Notch signaling pathway	P01110	Presenilin	CAEEL|WormBase=WBGene00004769|UniProtKB=P52166	Presenilin sel-12	IGI	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00019	Endothelin signaling pathway	P00567	PKG	MONDO|Ensembl=ENSMODG00000020783|UniProtKB=F6YKH9	cGMP-dependent protein kinase	ISS	12764134	PubMed	PTHR24353:SF24	SUBFAMILY NOT NAMED
P00020	FAS signaling pathway	P00622	FADD	PANTR|Ensembl=ENSPTRG00000004004|UniProtKB=H2Q4B6	FAS-associated death domain protein	ISS	7538907	PubMed	PTHR15077:SF8	FAS-ASSOCIATED DEATH DOMAIN PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02746	Heme biosynthesis	P02982	Protoheme IX farnesyl transferase	YEAST|SGD=S000006093|UniProtKB=P21592	Protoheme IX farnesyltransferase, mitochondrial	ISS			PTHR43448:SF2	PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	PANTR|Ensembl=ENSPTRG00000012613|UniProtKB=H2QIY0	Uncharacterized protein	ISS	11907044	PubMed	PTHR44025:SF5	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P06587	Nicotine pharmacodynamics pathway	P06590	GNG	HUMAN|HGNC=4404|UniProtKB=P59768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00021	FGF signaling pathway	P00632	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	12655147	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00944	Actin	MONDO|Ensembl=ENSMODG00000023940|UniProtKB=F6RFW8	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00029	Huntington disease	P00780	Microtubule	RAT|RGD=628596|UniProtKB=P69897	Tubulin beta-5 chain	ISS	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04393	Ras Pathway	P04542	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00964	p90RSK	BOVIN|Ensembl=ENSBTAG00000017639|UniProtKB=F1MZW8	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00036	Interleukin signaling pathway	P00983	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04665	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01341	Elk1	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	ISS	11279280	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00034	Integrin signalling pathway	P00941	Integrin alpha	MOUSE|MGI=MGI=109442|UniProtKB=A2ARA8	Integrin alpha-8	IPI	3487386	PubMed	PTHR23220:SF5	INTEGRIN ALPHA-8
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05916	Opioid prodynorphin pathway	P06002	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	TAS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01153	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000008269|UniProtKB=H2QBE4	Cadherin 3, type 1, P-cadherin (Placental)	ISS	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P00029	Huntington disease	P00778	NMDA receptor	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	PANTR|Ensembl=ENSPTRG00000002643|UniProtKB=H2Q244	Uncharacterized protein	ISS	12888804	PubMed	PTHR43940:SF7	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT GAMMA
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	IGI	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00009	Axon guidance mediated by netrin	P00356	UNC-5	MACMU|Ensembl=ENSMMUG00000010638|UniProtKB=F7BCW0	Uncharacterized protein	ISS			PTHR12582:SF5	NETRIN RECEPTOR UNC5D
P02728	Arginine biosynthesis	P02840	Argininosuccinate synthase	DEIRA|EnsemblGenome=DR_0674|UniProtKB=Q9RWJ4	Argininosuccinate synthase	ISS			PTHR11587:SF2	ARGININOSUCCINATE SYNTHASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DANRE|ZFIN=ZDB-GENE-000322-1|UniProtKB=Q9I8V1	Actin, alpha 1, skeletal muscle	IDA	11889139	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00036	Interleukin signaling pathway	P00977	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	IC	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	8787761	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P05916	Opioid prodynorphin pathway	P06002	G-protein	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00018	EGF receptor signaling pathway	P00563	Gab	MACMU|Ensembl=ENSMMUG00000000828|UniProtKB=F6Q223	GRB2-associated-binding protein 1 isoform a	ISS	15356145	PubMed	PTHR12156:SF18	GRB2-ASSOCIATED-BINDING PROTEIN 1
P00005	Angiogenesis	P00223	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	ARATH|TAIR=AT3G23580|UniProtKB=P50651	Ribonucleoside-diphosphate reductase small chain A	ISS			PTHR23409:SF24	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN A
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	ORYSJ|EnsemblGenome=OS05G0491100|UniProtKB=Q6F332	Calmodulin-2	ISS	10487978	PubMed	PTHR23050:SF324	CALMODULIN-2-RELATED
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04547	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00030	Hypoxia response via HIF activation	P00814	P300	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	MOUSE|MGI=MGI=95819|UniProtKB=P35438	Glutamate receptor ionotropic, NMDA 1	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00047	PDGF signaling pathway	P01167	Ets	ORNAN|Ensembl=ENSOANG00000006418|UniProtKB=F6WHZ1	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF161	FRIEND LEUKEMIA INTEGRATION 1 TRANSCRIPTION FACTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00012	Cadherin signaling pathway	P00476	Yes	RAT|RGD=3977|UniProtKB=F1LM93	Tyrosine-protein kinase Yes	ISS	11078745	PubMed	PTHR24418:SF90	TYROSINE-PROTEIN KINASE YES
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	XENTR|Xenbase=XB-GENE-484032|UniProtKB=F6QWD3	Tyrosine-protein kinase receptor	ISS	11182407	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00060	Ubiquitin proteasome pathway	P01492	E1	LEIMA|EnsemblGenome=LmjF.23.0550|UniProtKB=Q9NF77	Putative ubiquitin-activating enzyme e1	ISS			PTHR10953:SF4	GH24511P
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00018	EGF receptor signaling pathway	P00547	PP2A	ORNAN|Ensembl=ENSOANG00000008492|UniProtKB=F6XL57	Uncharacterized protein	ISS	12110603	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00321	HSP70	TAKRU|Ensembl=ENSTRUG00000000384|UniProtKB=H2RL84	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF256	HSP70 PROTEIN-RELATED
P00034	Integrin signalling pathway	P00925	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IDA	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MOUSE|MGI=MGI=1933206|UniProtKB=A2AIR5	Protein Grin3a	ISS	11319238	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00044	Nicotinic acetylcholine receptor signaling pathway	P01095	beta	RAT|RGD=2350|UniProtKB=P12390	Neuronal acetylcholine receptor subunit beta-2	ISS	15155845	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00790	beta-Tubulin	PHYPA|Gene=PHYPADRAFT_186458|UniProtKB=Q6TYR7	Beta-tubulin 1	ISS	9454836	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00030	Hypoxia response via HIF activation	P00814	P300	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00021	FGF signaling pathway	P00644	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IGI	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00036	Interleukin signaling pathway	P00987	SRF	HUMAN|HGNC=11291|UniProtKB=P11831	Serum response factor	IC	15326221	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00049	Parkinson disease	P01238	14-3-3	DANRE|ZFIN=ZDB-GENE-011115-1|UniProtKB=Q6PC29	14-3-3 protein gamma-1	ISS	8381897	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P04393	Ras Pathway	P04570	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02726	Aminobutyrate degradation	P02824	Succinate semi-aldehyde dehydrogenase	DEIRA|EnsemblGenome=DR_A0343|UniProtKB=O32507	Succinate-semialdehyde dehydrogenase [NADP(+)]	ISS			PTHR43217:SF2	SUBFAMILY NOT NAMED
P00020	FAS signaling pathway	P00620	CytochromeC	NEUCR|EnsemblGenome=EFNCRG00000009557|UniProtKB=P07142	Cytochrome c1, heme protein, mitochondrial	IGI	15163634	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	BRAFL|Gene=BRAFLDRAFT_220697|UniProtKB=C3ZSF0	Putative uncharacterized protein	ISS	9740024	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04393	Ras Pathway	P04573	Elk-1	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	3183861	gi	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00053	T cell activation	P01298	NFkappaB	CHICK|Ensembl=ENSGALG00000012304|UniProtKB=Q04861	Nuclear factor NF-kappa-B p105 subunit	IGI	9133421	PubMed	PTHR24169:SF9	NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00029	Huntington disease	P00796	Kainate receptor	CHICK|Ensembl=ENSGALG00000015434|UniProtKB=F1NU20	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MOUSE|MGI=MGI=99842|UniProtKB=Q02284	5-hydroxytryptamine receptor 1F	ISS	11701344	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04630	PP2A	MONDO|Ensembl=ENSMODG00000019001|UniProtKB=F7CP86	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00052	TGF-beta signaling pathway	P01292	RSmads	HUMAN|HGNC=6771|UniProtKB=Q99717	Mothers against decapentaplegic homolog 5	TAS	9395284	PubMed	PTHR13703:SF36	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P06959	CCKR signaling map	P07100	Dynamin	HUMAN|HGNC=2972|UniProtKB=Q05193	Dynamin-1	RCA	21156802	PubMed	PTHR11566:SF32	DYNAMIN-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-963560|UniProtKB=Q0VFC4	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00004	Alzheimer disease-presenilin pathway	P00163	Erb-B4 C-terminal fragment	PANTR|Ensembl=ENSPTRG00000012883|UniProtKB=H2QJC5	Receptor protein-tyrosine kinase	ISS	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00013	Cell cycle	P00480	Proteasome	TAKRU|Ensembl=ENSTRUG00000002031|UniProtKB=H2RX03	Uncharacterized protein	ISS	97227943	PubMed	PTHR10678:SF4	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00729	Goalpha	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	ISS	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00640	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06796	Npr2	MOUSE|MGI=MGI=97372|UniProtKB=Q6VVW5	Atrial natriuretic peptide receptor 2	RCA			PTHR11920:SF305	ATRIAL NATRIURETIC PEPTIDE RECEPTOR 2
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	DAPPU|EnsemblGenome=DAPPUDRAFT_305830|UniProtKB=E9GTE8	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00047	PDGF signaling pathway	P01165	SRF	PANTR|Ensembl=ENSPTRG00000018189|UniProtKB=H2QT21	Uncharacterized protein	ISS	15326221	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000018511|UniProtKB=F7A8W3	Cadherin-8	ISS	8120095	PubMed	PTHR24027:SF273	CADHERIN-8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	CANLF|Ensembl=ENSCAFG00000010255|UniProtKB=E2RPY4	Uncharacterized protein	ISS	2433589	PubMed	PTHR11767:SF52	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	BOVIN|Ensembl=ENSBTAG00000007882|UniProtKB=G3X7Z2	Uncharacterized protein	IDA	8386525	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00006	Apoptosis signaling pathway	P00260	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00463	betacatenin	PANTR|Ensembl=ENSPTRG00000023062|UniProtKB=H2R2U1	Catenin (Cadherin-associated protein), beta 1, 88kDa	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	CAEEL|WormBase=WBGene00000391|UniProtKB=Q22922	CytiDine Deaminase	ISS	17551074	gi	PTHR11644:SF11	CYTIDINE DEAMINASE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	PANTR|Ensembl=ENSPTRG00000018449|UniProtKB=H2QTG5	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P06959	CCKR signaling map	P07063	MAP3K14	HUMAN|HGNC=6853|UniProtKB=Q99558	Mitogen-activated protein kinase kinase kinase 14	RCA	12740336	PubMed	PTHR24361:SF226	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 14
P00057	Wnt signaling pathway	P01451	Galpha	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	IDA	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00046	Oxidative stress response	P01135	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	91232861	PubMed	PTHR24070:SF385	GTPASE HRAS
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CHICK|Ensembl=ENSGALG00000008512|UniProtKB=F1P0S6	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IGI	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	DANRE|ZFIN=ZDB-GENE-040625-181|UniProtKB=Q6IQV0	Uncharacterized protein	ISS	10617630	PubMed	PTHR24054:SF28	CASEIN KINASE 2 ALPHA 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	RCA	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00010	B cell activation	P00381	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00056	VEGF signaling pathway	P01408	Akt/PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00047	PDGF signaling pathway	P01153	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	MOUSE|MGI=MGI=109482|UniProtKB=P97445	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	11976940	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	RAT|RGD=1561842|UniProtKB=D3Z8B1	Homeobox protein engrailed-like	ISS	12356903	PubMed	PTHR24341:SF5	HOMEOBOX PROTEIN ENGRAILED-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000002339|UniProtKB=H2R368	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00018	EGF receptor signaling pathway	P00562	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000007754|UniProtKB=F7BXD9	Uncharacterized protein	ISS	8120095	PubMed	PTHR43956:SF6	PROTOCADHERIN-16
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00572	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95815|UniProtKB=P39087	Glutamate receptor ionotropic, kainate 2	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00052	TGF-beta signaling pathway	P01284	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00006	Apoptosis signaling pathway	P00269	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00049	Parkinson disease	P01212	p38 MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00059	p53 pathway	P04626	GADD45	CANLF|Ensembl=ENSCAFG00000019386|UniProtKB=E2R2S2	Uncharacterized protein	ISS	10097101	PubMed	PTHR10411:SF5	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00029	Huntington disease	P00797	p53	MACMU|Ensembl=ENSMMUG00000003890|UniProtKB=F7H5L4	Uncharacterized protein	ISS			PTHR12195:SF2	CYTOPLASMIC FMR1-INTERACTING PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	TAS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00036	Interleukin signaling pathway	P00983	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	12068308	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00052	TGF-beta signaling pathway	P01289	I-Smads	PANTR|Ensembl=ENSPTRG00000007198|UniProtKB=H2Q9N7	Mothers against decapentaplegic homolog	ISS	9335505	PubMed	PTHR13703:SF28	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 6
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02920	dCTP deaminase	DROME|FlyBase=FBgn0038491|UniProtKB=Q9VEM0	CG5292, isoform A	ISS			PTHR11079:SF92	TRNA-SPECIFIC ADENOSINE DEAMINASE 2
P00057	Wnt signaling pathway	P01472	Histone deacetylase	USTMA|Gene=UMAG_11308|UniProtKB=A0A0D1CEH3	Chromosome 2, whole genome shotgun sequence	IDA	10485845	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01150	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00638	PLCgamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	BOVIN|Ensembl=ENSBTAG00000000219|UniProtKB=F1MCL3	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00021	FGF signaling pathway	P00632	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	PANTR|Ensembl=ENSPTRG00000002086|UniProtKB=H2Q1A9	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	15313841	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	STRPU|EnsemblGenome=SPU_013273|UniProtKB=W4YBZ7	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00047	PDGF signaling pathway	P01163	c-Jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	BOVIN|Ensembl=ENSBTAG00000003043|UniProtKB=P63212	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00006	Apoptosis signaling pathway	P00274	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00048	PI3 kinase pathway	P01185	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00059	p53 pathway	P04630	PP2A	RAT|RGD=3381|UniProtKB=P62716	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00373	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01451	Galpha	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	IDA	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ORNAN|Ensembl=ENSOANG00000007405|UniProtKB=F7CIV4	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Ensembl=ENSPTRG00000013825|UniProtKB=H2RAK4	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=4594|UniProtKB=Q14416	Metabotropic glutamate receptor 2	IDA	9407094	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	LEIMA|EnsemblGenome=LmjF.35.4010|UniProtKB=Q9GNR4	Protein kinase A catalytic subunit isoform 1	ISS	14744463	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02776	Serine glycine biosynthesis	P03160	Phosphoglycerate dehydrogenase	HUMAN|HGNC=8923|UniProtKB=O43175	D-3-phosphoglycerate dehydrogenase	ISS			PTHR42938:SF5	D-3-PHOSPHOGLYCERATE DEHYDROGENASE
P00021	FGF signaling pathway	P00629	PP2A	MACMU|Ensembl=ENSMMUG00000013047|UniProtKB=F7H808	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04556	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04547	Ras	BOVIN|Ensembl=ENSBTAG00000009778|UniProtKB=E1BMX0	Uncharacterized protein	ISS	3023884	PubMed	PTHR24070:SF186	GTPASE KRAS
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	BRADU|EnsemblGenome=BAC50298|UniProtKB=P24060	Serine hydroxymethyltransferase	ISS			PTHR11680:SF19	SUBFAMILY NOT NAMED
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	RAT|RGD=2847|UniProtKB=P28565	5-hydroxytryptamine receptor 1D	IEA	12181435	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000010591|UniProtKB=H2R6B7	Uncharacterized protein	ISS	11554554	PubMed	PTHR24356:SF246	SERINE/THREONINE-PROTEIN KINASE N1
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	7937853	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00056	VEGF signaling pathway	P01407	Erk	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00557	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	BOVIN|Ensembl=ENSBTAG00000019988|UniProtKB=F1N2V3	Uncharacterized protein	ISS	11534853	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00890	ELK	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	ISS	11151091	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00010	B cell activation	P00402	Jnk	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00025	Hedgehog signaling pathway	P00682	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00046	Oxidative stress response	P01135	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	BRAFL|Gene=BRAFLDRAFT_57361|UniProtKB=C3XRD1	Putative uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF263	SUBFAMILY NOT NAMED
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P02738	De novo purine biosynthesis	P02902	ADP reductase	SYNY3|EnsemblGenome=BAA18334|UniProtKB=P74240	Ribonucleoside-diphosphate reductase subunit alpha	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	87218499	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01171	PLCgamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00036	Interleukin signaling pathway	P00981	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	TAS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P01486	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	BOVIN|Ensembl=ENSBTAG00000019210|UniProtKB=F1MJV4	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P02772	Pyruvate metabolism	P03139	Lactate Dehydrogenase	TRIVA|Gene=TVAG_495880|UniProtKB=O96445	L-lactate dehydrogenase	IDA	10339579	PubMed	PTHR23382:SF0	MALATE DEHYDROGENASE 2, MITOCHONDRIAL-RELATED
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DICDI|dictyBase=DDB_G0289811|UniProtKB=Q54GX7	Actin-10	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00021	FGF signaling pathway	P00629	PP2A	HUMAN|HGNC=23732|UniProtKB=Q66LE6	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform	ISS			PTHR11871:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B DELTA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00644	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IGI	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	ISS	1482697	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	ARATH|TAIR=AT4G34460|UniProtKB=P49177	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF48	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	TAS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ENTHI|EnsemblGenome=EHI_107290|UniProtKB=B1N2P0	Actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00018	EGF receptor signaling pathway	P00545	JNK1-3	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IGI	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	DANRE|ZFIN=ZDB-GENE-040426-2879|UniProtKB=Q6IQJ2	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00052	TGF-beta signaling pathway	P01284	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00023	General transcription regulation	P00660	RNA Polymerase II	CHICK|Ensembl=ENSGALG00000012291|UniProtKB=Q9PT88	RNA polymerase common subunit RPB6	ISS	6522685	gi	PTHR10773:SF12	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04393	Ras Pathway	P04566	Stat 1/3	CANLF|Ensembl=ENSCAFG00000015213|UniProtKB=E2RB82	Signal transducer and activator of transcription	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00054	Toll receptor signaling pathway	P01357	MEKK1	RAT|RGD=620966|UniProtKB=Q62925	Mitogen-activated protein kinase kinase kinase 1	ISS	12049732	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00046	Oxidative stress response	P01129	JNK1/2	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00018	EGF receptor signaling pathway	P00547	PP2A	BRAFL|Gene=BRAFLDRAFT_113834|UniProtKB=C3ZG26	Serine/threonine-protein phosphatase	ISS			PTHR11668:SF24	SERINE/THREONINE-PROTEIN PHOSPHATASE 6 CATALYTIC SUBUNIT
P00057	Wnt signaling pathway	P01444	Wnt	CAEEL|WormBase=WBGene00000858|UniProtKB=P34889	Protein Wnt-2	IDA	11266476	PubMed	PTHR12027:SF77	PROTEIN WNT-5
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	MOUSE|MGI=MGI=106217|UniProtKB=Q61290	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	14507926	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	PANTR|Ensembl=ENSPTRG00000013542|UniProtKB=H2QKF3	Uncharacterized protein	ISS			PTHR10665:SF2	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS-LIKE PROTEIN
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	DROME|FlyBase=FBgn0260964|UniProtKB=Q8IH57	GH10249p	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00811	Arp2/3 complex	MOUSE|MGI=MGI=3648102|UniProtKB=E9Q2K4	Actin-related protein 2/3 complex subunit 5	TAS	12473693	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	TAS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00056	VEGF signaling pathway	P01411	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P04393	Ras Pathway	P04566	Stat 1/3	CANLF|Ensembl=ENSCAFG00000015213|UniProtKB=E2RB82	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	ORNAN|Ensembl=ENSOANG00000012083|UniProtKB=F7FPY5	Actin-related protein 2/3 complex subunit 4	ISS	9230079	PubMed	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00012	Cadherin signaling pathway	P00470	F-actin	DROME|FlyBase=FBgn0011743|UniProtKB=P45891	Actin-like protein 53D	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00778	NMDA receptor	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00056	VEGF signaling pathway	P01414	PLC-gamma	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00054	Toll receptor signaling pathway	P01368	MKK2	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IC	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	BOVIN|Ensembl=ENSBTAG00000009269|UniProtKB=F1MCM2	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00057	Wnt signaling pathway	P01443	Phospholipase C	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	CANLF|Ensembl=ENSCAFG00000008653|UniProtKB=F1PE26	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00019	Endothelin signaling pathway	P00591	PLCbeta	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01189	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	TAS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	IDA	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00049	Parkinson disease	P01238	14-3-3	XENTR|Xenbase=XB-GENE-1006026|UniProtKB=Q5XGC8	14-3-3 protein beta/alpha	ISS	10407019	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01307	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00022	General transcription by RNA polymerase I	P00652	RNA Polymerase I  Complex	CAEEL|WormBase=WBGene00010230|UniProtKB=P34476	Probable DNA-directed RNA polymerases I and III subunit RPAC2	ISS			PTHR13946:SF28	DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2
P00047	PDGF signaling pathway	P01161	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00973	PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Gene=HTR1F|UniProtKB=Q9N2D9	5-hydroxytryptamine receptor 1F (Fragment)	IDA	12181435	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00053	T cell activation	P01332	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12539654	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00775	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	3755548	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	MOUSE|MGI=MGI=103296|UniProtKB=P97305	Nuclear factor of activated T-cells, cytoplasmic 3	ISS	9462517	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00006	Apoptosis signaling pathway	P00297	NFkappaB	MOUSE|MGI=MGI=1099800|UniProtKB=Q9WTK5	Nuclear factor NF-kappa-B p100 subunit	IDA	9133421	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00022	General transcription by RNA polymerase I	P00650	TAF-IB	SCHPO|PomBase=SPCC1259.06|UniProtKB=O94706	Transcription initiation factor TFIID subunit 8	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=98962|UniProtKB=P28047	Protein Wnt-7b	IDA	11266476	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00010	B cell activation	P00376	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P00018	EGF receptor signaling pathway	P00549	EGF	MACMU|Ensembl=ENSMMUG00000002314|UniProtKB=F7D8W9	Amphiregulin	ISS	4502199	gi	PTHR10740:SF12	AMPHIREGULIN
P05913	Enkephalin release	P05975	GPCR (s)	HUMAN|HGNC=8156|UniProtKB=P35372	Mu-type opioid receptor	ISS	12093103	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P04379	Beta3 adrenergic receptor signaling pathway	P04449	Beta3	BOVIN|Ensembl=ENSBTAG00000017981|UniProtKB=P46626	Beta-3 adrenergic receptor	ISS	12063255	PubMed	PTHR24248:SF3	BETA-3 ADRENERGIC RECEPTOR
P00048	PI3 kinase pathway	P01177	P110ACT	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02752	Mannose metabolism	P03019	P-Mannose mutase	BOVIN|Ensembl=ENSBTAG00000004009|UniProtKB=Q0VC17	Phosphomannomutase	ISS	11042159	PubMed	PTHR10466:SF1	PHOSPHOMANNOMUTASE 1
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00117	E-cadherin C-terminal fragment	XENTR|Xenbase=XB-GENE-482277|UniProtKB=F6QAX3	Uncharacterized protein	ISS	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	PSEAE|EnsemblGenome=PA3637|UniProtKB=Q9HXZ4	CTP synthase	ISS			PTHR11550:SF0	CTP SYNTHASE
P00021	FGF signaling pathway	P00634	MEKK1-5	CANLF|Ensembl=ENSCAFG00000000760|UniProtKB=E2R9L4	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02742	Tetrahydrofolate biosynthesis	P02951	GTP cyclohydrolase	ANOGA|EnsemblGenome=AGAP006441|UniProtKB=Q7Q5H2	AGAP006441-PA	ISS			PTHR11109:SF0	GTP CYCLOHYDROLASE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01177	P110ACT	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04396	Vitamin D metabolism and pathway	P04603	1alpha-Hydroxylase	PANTR|Ensembl=ENSPTRG00000012928|UniProtKB=H2QJF6	Uncharacterized protein	ISS	11013342	PubMed	PTHR24291:SF6	STEROL 26-HYDROXYLASE, MITOCHONDRIAL
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01154	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00048	PI3 kinase pathway	P01182	Ras	DICPU|Gene=DICPUDRAFT_91367|UniProtKB=F0ZB76	Putative uncharacterized protein rasD	ISS	6091907	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	LEIMA|EnsemblGenome=LmjF.35.1000|UniProtKB=Q9NHE2	Casein kinase 1 isoform 1	IDA	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	DANRE|ZFIN=ZDB-GENE-030131-825|UniProtKB=Q7T2E3	Casein kinase I isoform delta-A	ISS	10617630	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00906	Rap1	MOUSE|MGI=MGI=894315|UniProtKB=Q99JI6	Ras-related protein Rap-1b	ISS	10476970	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	MOUSE|MGI=MGI=109482|UniProtKB=P97445	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	IDA	14624853	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00018	EGF receptor signaling pathway	P00556	PLCgamma	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00034	Integrin signalling pathway	P00951	Jnk	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IDA	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02748	Isoleucine biosynthesis	P02994	Branched chain amino acid aminotransferase	HALSA|EnsemblGenome=VNG_2122G|UniProtKB=Q9HNF8	Branched-chain amino acid aminotransferase	ISS			PTHR42743:SF3	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE-LIKE PROTEIN 1-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00190	RasGAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	ISS	88318957	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00005	Angiogenesis	P00190	RasGAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00018	EGF receptor signaling pathway	P00547	PP2A	HUMAN|HGNC=9313|UniProtKB=Q16537	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	ISS	8703017	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DROME|FlyBase=FBgn0003093|UniProtKB=P13678	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00025	Hedgehog signaling pathway	P00682	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	10514528	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P05731	GABA-B receptor II signaling	P05754	Ggamma	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	RCA	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00057	Wnt signaling pathway	P01428	Frizzled	ANOGA|Gene=AgaP_AGAP011382|UniProtKB=Q7Q2X0	AGAP011382-PA (Fragment)	ISS	8717036	PubMed	PTHR11309:SF47	FRIZZLED
P05918	p38 MAPK pathway	P06040	MSK1	CHICK|Gene_ORFName=RCJMB04_14g1|UniProtKB=Q5F3L1	Ribosomal protein S6 kinase alpha-5	ISS	9687510	PubMed	PTHR24351:SF115	RIBOSOMAL PROTEIN S6 KINASE ALPHA-5
P00049	Parkinson disease	P01230	Src kinase	PANTR|Ensembl=ENSPTRG00000018511|UniProtKB=H2QTK7	Tyrosine-protein kinase	ISS	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	PANTR|Ensembl=ENSPTRG00000013428|UniProtKB=H2QK88	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF358	MYOSIN-7B
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P04396	Vitamin D metabolism and pathway	P04603	1alpha-Hydroxylase	MACMU|Ensembl=ENSMMUG00000022144|UniProtKB=F7H3A6	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	ISS	11013342	PubMed	PTHR24291:SF3	25-HYDROXYVITAMIN D-1 ALPHA HYDROXYLASE, MITOCHONDRIAL
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	BOVIN|Ensembl=ENSBTAG00000034854|UniProtKB=F1N246	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=12789|UniProtKB=Q93098	Protein Wnt-8b	IDA	8717036	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00047	PDGF signaling pathway	P01175	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	7680960	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01179	PKB	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00371	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00060	Ubiquitin proteasome pathway	P01492	E1	CAEEL|WormBase=WBGene00004341|UniProtKB=Q19360	NEDD8-activating enzyme E1 catalytic subunit	ISS			PTHR10953:SF6	NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00059	p53 pathway	G04694	p110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MOUSE|MGI=MGI=88399|UniProtKB=P32211	Muscarinic acetylcholine receptor M4	TAS	12181435	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00024	Glycolysis	P00679	Aldolase	PANTR|Gene=ALDOA|UniProtKB=A5A6I5	Fructose-bisphosphate aldolase A	ISS	84261525	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00005	Angiogenesis	P00181	SHP2	MONDO|Ensembl=ENSMODG00000003120|UniProtKB=F6WVD2	Tyrosine-protein phosphatase non-receptor type	ISS	95163101	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	RAT|RGD=628852|UniProtKB=Q02294	Voltage-dependent N-type calcium channel subunit alpha-1B	IDA	14507926	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00023	General transcription regulation	P00662	TFIIA complex	ARATH|TAIR=AT1G07470|UniProtKB=Q93VP4	At1g07470/F22G5_13	ISS	600519	OMIM	PTHR12694:SF13	TFIIA-L3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	IDA	19114921	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	ANOGA|EnsemblGenome=AGAP010278|UniProtKB=Q7Q0L5	AGAP010278-PA	ISS			PTHR22778:SF16	DIHYDROFOLATE REDUCTASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	NEUCR|EnsemblGenome=EFNCRG00000002727|UniProtKB=Q1K5E9	Aldehyde dehydrogenase	IC			PTHR11699:SF211	ALDEHYDE DEHYDROGENASE 5, MITOCHONDRIAL
P02778	Sulfate assimilation	P03167	Sulfate adenylyltransferase	ARATH|TAIR=AT5G43780|UniProtKB=Q9S7D8	ATP sulfurylase 4, chloroplastic	ISS			PTHR11055:SF18	ATP SULFURYLASE 1, CHLOROPLASTIC-RELATED
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	MONDO|Ensembl=ENSMODG00000019262|UniProtKB=F6Q8L1	Receptor protein serine/threonine kinase	ISS			PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P00048	PI3 kinase pathway	P01199	Galpha	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05918	p38 MAPK pathway	P06031	p38alpha	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00976	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00011	Blood coagulation	P00458	GP IIIa	MOUSE|MGI=MGI=96612|UniProtKB=O54890	Integrin beta-3	ISS	4206165	gi	PTHR10082:SF25	INTEGRIN BETA-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	HUMAN|HGNC=1392|UniProtKB=Q15878	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	8386525	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00056	VEGF signaling pathway	P01407	Erk	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	HUMAN|HGNC=14656|UniProtKB=Q8TD84	Down syndrome cell adhesion molecule-like protein 1	ISS			PTHR44107:SF3	DOWN SYNDROME CELL ADHESION MOLECULE-LIKE PROTEIN 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04395	Vasopressin synthesis	P04597	Signal Peptide	TAKRU|Ensembl=ENSTRUG00000015413|UniProtKB=H2UR30	Uncharacterized protein	ISS	9756087	PubMed	PTHR11681:SF13	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00181	SHP2	MACMU|Ensembl=ENSMMUG00000010203|UniProtKB=F6SIN0	Tyrosine-protein phosphatase non-receptor type	ISS			PTHR19134:SF65	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 6
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05918	p38 MAPK pathway	P06021	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	15470041	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05943	GRK2	RAT|RGD=2062|UniProtKB=P26817	Beta-adrenergic receptor kinase 1	RCA	10852916	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	CHLRE|EnsemblGenome=CHLREDRAFT_133971|UniProtKB=A8I305	Glutamine synthetase	ISS			PTHR20852:SF79	GLUTAMINE SYNTHETASE CYTOSOLIC ISOZYME 1-1-RELATED
P05734	Synaptic vesicle trafficking	P05779	Synaptobrevin	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	RCA	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	IDA	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00005	Angiogenesis	P00184	Src	PANTR|Ensembl=ENSPTRG00000013474|UniProtKB=H2QKB4	Tyrosine-protein kinase	ISS	8054685	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	ORYSJ|EnsemblGenome=OS03G0285800|UniProtKB=Q10N20	Mitogen-activated protein kinase 5	TAS			PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	MOUSE|MGI=MGI=3584516|UniProtKB=E9Q1T6	Protein Lrp3	ISS	11907044	PubMed	PTHR44062:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IDA	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CHICK|Ensembl=ENSGALG00000014539|UniProtKB=F1N861	Uncharacterized protein	ISS	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	DANRE|ZFIN=ZDB-GENE-090312-91|UniProtKB=F1QR92	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF82	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-6
P00056	VEGF signaling pathway	P01422	eNOS	MONDO|Ensembl=ENSMODG00000003903|UniProtKB=F6S3S1	Nitric oxide synthase	ISS	9837777	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00627	ERK1-2	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01336	Jnk	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IGI	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IC	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MACMU|Ensembl=ENSMMUG00000004982|UniProtKB=F7AU14	Serine/threonine-protein kinase receptor	ISS	9395284	PubMed	PTHR23255:SF66	SERINE/THREONINE-PROTEIN KINASE RECEPTOR R3
P00018	EGF receptor signaling pathway	P00551	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IPI	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00053	T cell activation	P01319	PAK	MONDO|Ensembl=ENSMODG00000005255|UniProtKB=F7G800	Uncharacterized protein	ISS	7559398	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00053	T cell activation	P01300	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00970	Interleukin	HUMAN|HGNC=5977|UniProtKB=P40933	Interleukin-15	IC	7568001	PubMed	PTHR45114:SF1	INTERLEUKIN-15
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02913	Thymidylate synthase	FUSNN|EnsemblGenome=FN0240|UniProtKB=Q8RGP6	Thymidylate synthase	ISS			PTHR11548:SF1	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00780	Microtubule	ARATH|TAIR=AT5G23860|UniProtKB=P29516	Tubulin beta-8 chain	IDA	12932731	PubMed	PTHR11588:SF264	TUBULIN BETA-8 CHAIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-8225|UniProtKB=Q7SZZ5	Uncharacterized protein	ISS			PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DANRE|ZFIN=ZDB-GENE-040426-1178|UniProtKB=Q7SY24	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05918	p38 MAPK pathway	P05920	MAPKAP-K2	HUMAN|HGNC=6887|UniProtKB=P49137	MAP kinase-activated protein kinase 2	RCA	7923354	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00029	Huntington disease	P00805	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01352	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00059	p53 pathway	P04609	PI3K	RAT|RGD=1306541|UniProtKB=D3ZVF3	Phosphoinositide-3-kinase, class 2, beta polypeptide (Predicted)	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00012	Cadherin signaling pathway	P00470	F-actin	MACMU|Ensembl=ENSMMUG00000012054|UniProtKB=F6TII3	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MACMU|Ensembl=ENSMMUG00000022229|UniProtKB=F6Z2A8	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF16	MATRIX METALLOPROTEINASE-28
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00005	Angiogenesis	P00238	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	RAT|RGD=619966|UniProtKB=F1LQT1	Adenylate cyclase 7	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IDA	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00010	B cell activation	P00376	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P06216	SCW signaling pathway	P06329	SAX	DROME|Gene=Dmel_CG1891|UniProtKB=A0A0B4K7J3	Receptor protein serine/threonine kinase	IDA	9395284	PubMed	PTHR23255:SF72	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CHICK|Ensembl=ENSGALG00000011086|UniProtKB=P68139	Actin, alpha skeletal muscle	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P06959	CCKR signaling map	P07194	MAP2K1	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	RCA	9230117	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MOUSE|MGI=MGI=98179|UniProtKB=P10833	Ras-related protein R-Ras	ISS	7997267	PubMed	PTHR24070:SF245	RAS-RELATED PROTEIN R-RAS
P00004	Alzheimer disease-presenilin pathway	P00139	E-cadherin transmembrane fragment	PANTR|Ensembl=ENSPTRG00000008269|UniProtKB=H2QBE4	Cadherin 3, type 1, P-cadherin (Placental)	ISS	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P02753	Methionine biosynthesis	P03024	Homocysteine transmethylase	HUMAN|HGNC=7468|UniProtKB=Q99707	Methionine synthase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00021	FGF signaling pathway	P00629	PP2A	TAKRU|Ensembl=ENSTRUG00000006171|UniProtKB=H2SRH6	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B	ISS			PTHR11871:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B DELTA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00091	Aph-1	ANOGA|EnsemblGenome=AGAP009816|UniProtKB=Q7PM79	AGAP009816-PA	IDA	12110170	PubMed	PTHR12889:SF0	GAMMA-SECRETASE SUBUNIT APH-1
P00018	EGF receptor signaling pathway	P00565	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IGI	94179345	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00036	Interleukin signaling pathway	P00975	RasGAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	ISS	2842690	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00054	Toll receptor signaling pathway	P01365	TAB1	CANLF|Ensembl=ENSCAFG00000001332|UniProtKB=F1PLP7	Uncharacterized protein	ISS	10838074	PubMed	PTHR13832:SF533	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	HUMAN|HGNC=4597|UniProtKB=P41594	Metabotropic glutamate receptor 5	IDA	12488551	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	DANRE|ZFIN=ZDB-GENE-030131-6206|UniProtKB=F1Q5K4	Uncharacterized protein	IC	10938134	PubMed	PTHR13140:SF676	MYOSIN, HEAVY POLYPEPTIDE 2, FAST MUSCLE SPECIFIC
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000010095|UniProtKB=H2QEN8	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF323	CADHERIN-19
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01312	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IDA	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00030	Hypoxia response via HIF activation	P00814	P300	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	IDA	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00055	Transcription regulation by bZIP transcription factor	P01390	TFIIA complex	ARATH|TAIR=AT5G59230|UniProtKB=Q9FIF4	TFIIA-L3	ISS	600519	OMIM	PTHR12694:SF13	TFIIA-L3
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05915	Opioid proenkephalin pathway	P05991	Enkephalin	PANTR|Ensembl=ENSPTRG00000020270|UniProtKB=H2QW70	Proenkephalin	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000023940|UniProtKB=F6RFW8	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=98953|UniProtKB=P04426	Proto-oncogene Wnt-1	IDA	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	BOVIN|Gene=IGF2R|UniProtKB=P08169	Cation-independent mannose-6-phosphate receptor	ISS	11081635	PubMed	PTHR15071:SF17	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
P06213	DPP signaling pathway	P06290	FUR1	DROME|FlyBase=FBgn0004509|UniProtKB=P26016	Furin-like protease 1, isoforms 1/1-X/2	IEA	7737999	PubMed	PTHR42884:SF3	FURIN-LIKE PROTEASE 1, ISOFORMS 1/1-X/2
P00048	PI3 kinase pathway	P01189	PTEN	DROME|FlyBase=FBgn0026379|UniProtKB=Q7KMQ6	IP16020p	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MOUSE|MGI=MGI=87904|UniProtKB=P60710	Actin, cytoplasmic 1	IC	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	IDA	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	ISS	14765990	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00049	Parkinson disease	P01238	14-3-3	SCHMA|EnsemblGenome=Smp_002410|UniProtKB=Q95W36	14-3-3 epsilon 2	IDA	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_188187|UniProtKB=E9GJ31	Guanine nucleotide binding protein, q polypeptide	ISS	9166716	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00019	Endothelin signaling pathway	P00590	IP3 R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00019	Endothelin signaling pathway	P00572	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CANLF|Ensembl=ENSCAFG00000028654|UniProtKB=J9P702	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00034	Integrin signalling pathway	P00924	Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	IPI	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00986	eNOS	MOUSE|MGI=MGI=97362|UniProtKB=P70313	Nitric oxide synthase, endothelial	ISS	22462730	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CANLF|Ensembl=ENSCAFG00000015708|UniProtKB=F2Z4N0	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	RAT|RGD=628837|UniProtKB=P60711	Actin, cytoplasmic 1	IDA	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00034	Integrin signalling pathway	P00948	Rho	MONDO|Ensembl=ENSMODG00000000981|UniProtKB=F7ES59	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00586	Gq	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MOUSE|MGI=MGI=103307|UniProtKB=P54285	Voltage-dependent L-type calcium channel subunit beta-3	IC			PTHR11824:SF8	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-3
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF31	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IDA	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000014807|UniProtKB=F6W548	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	IDA	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	HALSA|EnsemblGenome=VNG_1160G|UniProtKB=P61136	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00005	Angiogenesis	P00203	Erk	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00108	ADAM10	PANTR|Ensembl=ENSPTRG00000007116|UniProtKB=H2Q9I4	ADAM metallopeptidase domain 10	ISS	12354787	PubMed	PTHR11905:SF4	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 10
P00006	Apoptosis signaling pathway	P00269	MAPK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95817|UniProtKB=Q8BMF5	Glutamate receptor ionotropic, kainate 4	ISS	1648176	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	IC	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P02733	Carnitine metabolism	P02866	Carnitine dehydratase	BOVIN|Ensembl=ENSBTAG00000032121|UniProtKB=A6QQD0	LOC100125578 protein	ISS			PTHR43949:SF6	SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	XENTR|Xenbase=XB-GENE-976753|UniProtKB=Q0VFR6	Syntaxin 1A (Brain)	ISS	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00029	Huntington disease	P00807	Actin	ORYSJ|EnsemblGenome=OS05G0106600|UniProtKB=Q65XH8	Os05g0106600 protein	IDA	14684598	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00057	Wnt signaling pathway	P01443	Phospholipase C	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	IDA	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00029	Huntington disease	P00790	beta-Tubulin	PHYPA|Gene=PHYPADRAFT_110341|UniProtKB=Q6TYR6	Beta-tubulin 2	ISS	12932731	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00580	ET-RA/B	CANLF|Gene=EDNRA|UniProtKB=Q5KSU9	Endothelin-1 receptor	ISS	91080923	PubMed	PTHR24243:SF31	ENDOTHELIN-1 RECEPTOR
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00030	Hypoxia response via HIF activation	P00819	AKT	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	TAS	12086862	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02765	Phenylalanine biosynthesis	P03100	Chorismate mutase	RHOBA|EnsemblGenome=RB8741|UniProtKB=Q7UMM1	Chorismate mutase	ISS			PTHR21164:SF0	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00219	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00047	PDGF signaling pathway	P01161	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00017	DNA replication	P00527	Histones	CHLRE|EnsemblGenome=CHLREDRAFT_100021|UniProtKB=A8HSA7	Histone H3	ISS	12413958	PubMed	PTHR11426:SF169	HISTONE H3
P00053	T cell activation	P01335	jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	CHICK|Ensembl=ENSGALG00000000681|UniProtKB=E1C3P6	Uncharacterized protein	ISS	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00021	FGF signaling pathway	P00643	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00203	Erk	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	XENTR|Xenbase=XB-GENE-6469705|UniProtKB=Q6P8G3	Actin, alpha sarcomeric/skeletal	ISS	10974003	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00005	Angiogenesis	P00221	JNK1	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	ISS	11707292	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00010	B cell activation	P00369	MEKK	HUMAN|HGNC=6855|UniProtKB=Q99759	Mitogen-activated protein kinase kinase kinase 3	IDA	9006902	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00019	Endothelin signaling pathway	P00588	ET1-4	MOUSE|MGI=MGI=95283|UniProtKB=P22387	Endothelin-1	ISS	12893655	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	TAS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00021	FGF signaling pathway	P00632	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00005	Angiogenesis	P00188	Ets	BOVIN|Ensembl=ENSBTAG00000002341|UniProtKB=A5PJG9	ETS1 protein	ISS	9157999	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00018	EGF receptor signaling pathway	P00551	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	BOVIN|Ensembl=ENSBTAG00000014614|UniProtKB=P62739	Actin, aortic smooth muscle	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00018	EGF receptor signaling pathway	P00557	PI3K	DROME|FlyBase=FBgn0015278|UniProtKB=Q7K3H0	LD28067p	IGI	7937853	PubMed	PTHR10048:SF64	LD28067P
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000014751|UniProtKB=H2R8D8	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	CAEEL|WormBase=WBGene00012929|UniProtKB=Q9NAH6	Ribosomal protein S6 kinase beta	ISS			PTHR24351:SF166	RIBOSOMAL PROTEIN S6 KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MOUSE|MGI=MGI=1336171|UniProtKB=Q9DAS9	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CHICK|Ensembl=ENSGALG00000015835|UniProtKB=F1NZT2	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04393	Ras Pathway	P04569	Cdc42	CAEBR|Gene=CBG13013|UniProtKB=A8XGW3	Protein CBR-CDC-42	ISS	11412997	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	DEIRA|EnsemblGenome=DR_1207|UniProtKB=Q9RV23	tRNA(Ile)-lysidine synthase	ISS			PTHR43033:SF1	TRNA ILE -LYSIDINE SYNTHASE
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00060	Ubiquitin proteasome pathway	P01491	E2	ARATH|TAIR=AT1G45050|UniProtKB=P42743	Ubiquitin-conjugating enzyme 15	ISS			PTHR44452:SF1	UBIQUITIN-CONJUGATING ENZYME 15-RELATED
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	HUMAN|HGNC=4579|UniProtKB=P39086	Glutamate receptor ionotropic, kainate 1	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00019	Endothelin signaling pathway	P00566	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	9298898	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	IDA	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P06959	CCKR signaling map	P07126	TCF7L2	HUMAN|HGNC=11634|UniProtKB=P15884	Transcription factor 4	RCA	17167838	PubMed	PTHR11793:SF10	TRANSCRIPTION FACTOR 4
P00020	FAS signaling pathway	P00611	Gelsolin	DROME|FlyBase=FBgn0010225|UniProtKB=Q07171	Gelsolin	IGI	9323209	PubMed	PTHR11977:SF39	GELSOLIN
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	AQUAE|EnsemblGenome=aq_1290|UniProtKB=O67321	Adenylosuccinate synthetase	IEP	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00049	Parkinson disease	P01211	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00017	DNA replication	P00527	Histones	TRIAD|EnsemblGenome=TriadG36142|UniProtKB=B3RZQ5	Histone H3	ISS	12413958	PubMed	PTHR11426:SF169	HISTONE H3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00796	Kainate receptor	MONDO|Ensembl=ENSMODG00000020977|UniProtKB=F6S5B1	Uncharacterized protein (Fragment)	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P02759	Pyridoxal-5-phosphate biosynthesis	P03058	Phosphohydroxythreonine aminotransferase	YEAST|SGD=S000005710|UniProtKB=P33330	Phosphoserine aminotransferase	ISS	9169874	PubMed	PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000022548|UniProtKB=F6Y9J9	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00270	Bcl-2	BOVIN|Gene=BCL2|UniProtKB=O02718	Apoptosis regulator Bcl-2	ISS	2250705	PubMed	PTHR11256:SF11	APOPTOSIS REGULATOR BCL-2
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04398	p53 pathway feedback loops 2	P04665	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01236	Casein kinase II	YEAST|SGD=S000005587|UniProtKB=P19454	Casein kinase II subunit alpha'	IDA	10806215	PubMed	PTHR24054:SF27	CASEIN KINASE II SUBUNIT ALPHA'
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000020947|UniProtKB=F7CY46	Uncharacterized protein	ISS	12181435	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P00052	TGF-beta signaling pathway	P01290	TAB	HUMAN|HGNC=18157|UniProtKB=Q15750	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1	IGI	8638164	PubMed	PTHR13832:SF533	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P02741	Flavin biosynthesis	P02940	Riboflavin synthase	YEAST|SGD=S000000460|UniProtKB=P38145	Riboflavin synthase	ISS			PTHR21098:SF0	RIBOFLAVIN SYNTHASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	ISS	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000000820|UniProtKB=Q5E9F0	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	ISS			PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Ensembl=ENSBTAG00000013632|UniProtKB=E1B965	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	BOVIN|Ensembl=ENSBTAG00000000820|UniProtKB=Q5E9F0	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	ISS	2122451	PubMed	PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P00006	Apoptosis signaling pathway	P00260	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000014577|UniProtKB=F7GRQ1	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF118	PROTOCADHERIN BETA-3
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	RAT|RGD=2746|UniProtKB=P31424	Metabotropic glutamate receptor 5	ISS	7476890	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CHICK|Ensembl=ENSGALG00000028749|UniProtKB=Q5ZMQ2	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000025373|UniProtKB=F6ZZG9	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00009	Axon guidance mediated by netrin	P00366	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12874273	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00005	Angiogenesis	P00203	Erk	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00970	Interleukin	BOVIN|Ensembl=ENSBTAG00000000277|UniProtKB=Q9TU73	Interleukin-18	IDA	10547157	PubMed	PTHR45200:SF1	INTERLEUKIN-18
P04393	Ras Pathway	P04547	Ras	HUMAN|HGNC=6407|UniProtKB=P01116	GTPase KRas	IDA	6287573	PubMed	PTHR24070:SF186	GTPASE KRAS
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00036	Interleukin signaling pathway	P00965	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01192	p110	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00054	Toll receptor signaling pathway	P01378	IRAKM	PANTR|Ensembl=ENSPTRG00000005187|UniProtKB=H2Q6E9	Interleukin-1 receptor-associated kinase 3	ISS			PTHR24419:SF7	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 3
P00023	General transcription regulation	P00666	TFIIE	CANLF|Ensembl=ENSCAFG00000011306|UniProtKB=E2R3P2	Uncharacterized protein	ISS	189962	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	XENTR|Xenbase=XB-GENE-491618|UniProtKB=Q6P378	Actin, cytoplasmic 2	ISS	3487386	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00048	PI3 kinase pathway	P01185	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	CHICK|Gene=CSNK1A1|UniProtKB=P67962	Casein kinase I isoform alpha	IDA	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00054	Toll receptor signaling pathway	P01375	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	P01443	Phospholipase C	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IDA	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01078	VAChT	SCHPO|PomBase=SPCC18.02|UniProtKB=O74852	Uncharacterized MFS-type transporter C18.02	IC	21863848	PubMed	PTHR23506:SF25	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	TAKRU|Ensembl=ENSTRUG00000017773|UniProtKB=H2V8M1	Uncharacterized protein (Fragment)	IDA	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	SCHMA|EnsemblGenome=Smp_059340|UniProtKB=C4QDC7	Guanine nucleotide-binding protein G(S) subunit alpha (Adenylate cyclase-stimulating G alpha protein),putative	ISS			PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00249	PAK	XENTR|Xenbase=XB-GENE-961764|UniProtKB=F6W3Y0	Uncharacterized protein	ISS	7559398	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	IDA	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P02738	De novo purine biosynthesis	P02898	Phosphoribosylformylglycinamide  synthase	MYCTU|EnsemblGenome=Rv0803|UniProtKB=P9WHL7	Phosphoribosylformylglycinamidine synthase subunit PurL	ISS			PTHR43555:SF1	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00550	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	8051109	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04398	p53 pathway feedback loops 2	P04651	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IDA	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00313	IKK	MACMU|Ensembl=ENSMMUG00000008351|UniProtKB=F7HRV5	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00019	Endothelin signaling pathway	P00572	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000001962|UniProtKB=F6V2H6	Uncharacterized protein	ISS	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IGI	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00021	FGF signaling pathway	P00641	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	CAEEL|WormBase=WBGene00017830|UniProtKB=Q19826	Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3	ISS	606023	OMIM	PTHR10917:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3
P00019	Endothelin signaling pathway	P00589	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	IGI	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00647	SHP2	DANRE|ZFIN=ZDB-GENE-030131-5911|UniProtKB=F1QZU5	Tyrosine-protein phosphatase non-receptor type	ISS	95163101	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00019	Endothelin signaling pathway	P00566	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04393	Ras Pathway	P04566	Stat 1/3	CANLF|Ensembl=ENSCAFG00000015213|UniProtKB=E2RB82	Signal transducer and activator of transcription	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1170702	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	DROME|FlyBase=FBgn0010399|UniProtKB=Q24418	Glutamate [NMDA] receptor subunit 1	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00053	T cell activation	P01336	Jnk	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ORYSJ|EnsemblGenome=OS06G0154500|UniProtKB=Q84UI5	Mitogen-activated protein kinase 1	ISS	11707292	PubMed	PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	176910	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00560	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06838	CTNNB1	MOUSE|MGI=MGI=88276|UniProtKB=Q02248	Catenin beta-1	RCA	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00060	Ubiquitin proteasome pathway	P01494	19S proteasome	DICPU|Gene=DICPUDRAFT_92867|UniProtKB=F0ZYD1	Putative uncharacterized protein	ISS			PTHR23073:SF8	26S PROTEASE REGULATORY SUBUNIT 6B
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01446	Calcineurin	PHANO|EnsemblGenome=SNOG_01980|UniProtKB=Q0V1Y4	Uncharacterized protein	ISS	12015605	PubMed	PTHR23056:SF4	PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Ensembl=ENSPTRG00000011042|UniProtKB=H2QGF5	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00047	PDGF signaling pathway	P01160	IP3 receptor	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	ARATH|TAIR=AT1G17580|UniProtKB=Q39160	Myosin-5	IC			PTHR13140:SF510	MYOSIN-17-RELATED
P00034	Integrin signalling pathway	P00925	MEK	MACMU|Ensembl=ENSMMUG00000019842|UniProtKB=F7FU91	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	BOVIN|Ensembl=ENSBTAG00000047202|UniProtKB=G3N3K3	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00059	p53 pathway	P01486	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04544	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12162872	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00036	Interleukin signaling pathway	P00976	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MOUSE|MGI=MGI=95823|UniProtKB=Q03391	Glutamate receptor ionotropic, NMDA 2D	IC	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2D.html	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P02780	Thiamin metabolism	P03184	Thiamine triphosphatase	RAT|RGD=727917|UniProtKB=Q8CGV7	Thiamine-triphosphatase	ISS	12466851	PubMed	PTHR14586:SF1	THIAMINE-TRIPHOSPHATASE
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00013	Cell cycle	P00480	Proteasome	MONDO|Ensembl=ENSMODG00000003986|UniProtKB=F7DST4	Uncharacterized protein	ISS	9426256	PubMed	PTHR10855:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12
P00010	B cell activation	P00376	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00060	Ubiquitin proteasome pathway	P01491	E2	PHYPA|Gene=PHYPADRAFT_165589|UniProtKB=A9SLJ8	Predicted protein	ISS			PTHR43898:SF1	UBIQUITIN-CONJUGATING ENZYME E2-17 KDA
P00059	p53 pathway	G01579	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00009	Axon guidance mediated by netrin	P00363	PI3K	ORNAN|Ensembl=ENSOANG00000005917|UniProtKB=F6QM53	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00019	Endothelin signaling pathway	P00570	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00047	PDGF signaling pathway	P01174	Rho	BOVIN|Ensembl=ENSBTAG00000027151|UniProtKB=E1BNB7	Uncharacterized protein	ISS	8649427	PubMed	PTHR12552:SF4	RHO GTPASE-ACTIVATING PROTEIN 26
P00021	FGF signaling pathway	P00637	MKK4,7	PANTR|Ensembl=ENSPTRG00000008783|UniProtKB=H2QCA7	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00023	General transcription regulation	P00669	TFIIEalpha	MACMU|Ensembl=ENSMMUG00000001596|UniProtKB=F7GV34	General transcription factor IIE subunit 1	ISS	92065982	PubMed	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05917	Opioid proopiomelanocortin pathway	P06009	K+ channel	RAT|RGD=61997|UniProtKB=O54912	Potassium channel subfamily K member 3	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00037	Ionotropic glutamate receptor pathway	P01015	Glu4	TAKRU|Ensembl=ENSTRUG00000011517|UniProtKB=H2TWL9	Uncharacterized protein (Fragment)	ISS	12497607	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00017	DNA replication	P00527	Histones	RAT|RGD=2321290|UniProtKB=D3ZK97	Histone H3	ISS	12413958	PubMed	PTHR11426:SF44	HISTONE H3.3C
P00018	EGF receptor signaling pathway	P00543	ERK1-2	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00920	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	IPI	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00029	Huntington disease	P00807	Actin	CANAL|CGD=CAL0064759|UniProtKB=Q5AKX0	Uncharacterized protein	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	CHICK|Gene=CHRM4|UniProtKB=P17200	Muscarinic acetylcholine receptor M4	TAS	12181435	PubMed	PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MONDO|Ensembl=ENSMODG00000005623|UniProtKB=F7CFG8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05917	Opioid proopiomelanocortin pathway	P06009	K+ channel	BOVIN|Ensembl=ENSBTAG00000018193|UniProtKB=E1BHX8	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00054	Toll receptor signaling pathway	P01375	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00054	Toll receptor signaling pathway	P01353	TANK	RAT|RGD=628859|UniProtKB=F1M101	Protein Tank	ISS			PTHR15249:SF0	TRAF FAMILY MEMBER-ASSOCIATED NF-KAPPA-B ACTIVATOR
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MACMU|Ensembl=ENSMMUG00000022347|UniProtKB=F6ZCH5	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00017	DNA replication	P00530	Top	MOUSE|MGI=MGI=98791|UniProtKB=Q64511	DNA topoisomerase 2-beta	RCA			PTHR10169:SF36	DNA TOPOISOMERASE 2-BETA
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00047	PDGF signaling pathway	P01154	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00056	VEGF signaling pathway	P01414	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BOVIN|Ensembl=ENSBTAG00000018020|UniProtKB=P04695	Guanine nucleotide-binding protein G(t) subunit alpha-1	ISS	10188796	PubMed	PTHR10218:SF67	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-1
P00045	Notch signaling pathway	P01104	Serrate	MACMU|Ensembl=ENSMMUG00000018116|UniProtKB=F7FGM9	Delta-like protein	ISS	12826675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	IDA	12039949	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00012	Cadherin signaling pathway	P00474	Wnt	RAT|RGD=621348|UniProtKB=Q9QXQ5	Protein Wnt-4	IDA	8717036	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	HUMAN|HGNC=5960|UniProtKB=O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00005	Angiogenesis	P00246	Ang-2	MOUSE|MGI=MGI=1202890|UniProtKB=O35608	Angiopoietin-2	ISS			PTHR19143:SF199	ANGIOPOIETIN-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02736	Coenzyme A biosynthesis	P02885	Pantothenate kinase	MACMU|Ensembl=ENSMMUG00000019956|UniProtKB=F6QZB9	Uncharacterized protein	ISS			PTHR12280:SF25	PANTOTHENATE KINASE 2, MITOCHONDRIAL
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00053	T cell activation	P01294	NFAT	RAT|RGD=1308692|UniProtKB=A0A0G2JTY4	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 (Predicted), isoform CRA_b	ISS	12787506	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	CANLF|Ensembl=ENSCAFG00000015094|UniProtKB=F1PT97	Uncharacterized protein	ISS	12932731	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P04393	Ras Pathway	P04557	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	IDA	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00006	Apoptosis signaling pathway	P00269	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	20216076	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	DANRE|Ensembl=ENSDARG00000059090|UniProtKB=E7FDL0	Uncharacterized protein	ISS	12441358	PubMed	PTHR24229:SF75	SUBFAMILY NOT NAMED
P00022	General transcription by RNA polymerase I	P00650	TAF-IB	MONDO|Ensembl=ENSMODG00000012785|UniProtKB=F6S0M5	Uncharacterized protein	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P05918	p38 MAPK pathway	P06031	p38alpha	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	RCA	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00037	Ionotropic glutamate receptor pathway	P01001	KA4	RAT|RGD=2734|UniProtKB=Q01812	Glutamate receptor ionotropic, kainate 4	IC	1648176	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00006	Apoptosis signaling pathway	P00321	HSP70	DANRE|ZFIN=ZDB-GENE-121214-31|UniProtKB=F1R9V3	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF239	HEAT SHOCK COGNATE 71 KDA PROTEIN
P00007	Axon guidance mediated by semaphorins	P00340	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	DICPU|Gene=DICPUDRAFT_47179|UniProtKB=F0ZI47	Putative uncharacterized protein rasB	ISS	93205383	PubMed	PTHR24070:SF206	RAS-LIKE PROTEIN RASB
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	PANTR|Ensembl=ENSPTRG00000002149|UniProtKB=H2R0U9	Uncharacterized protein	ISS	15226293	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00034	Integrin signalling pathway	P00925	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	HUMAN|HGNC=6856|UniProtKB=Q9Y6R4	Mitogen-activated protein kinase kinase kinase 4	IGI	9305639	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00057	Wnt signaling pathway	P01443	Phospholipase C	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	IDA	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00018	EGF receptor signaling pathway	P00543	ERK1-2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04548	ATF2	CHICK|Ensembl=ENSGALG00000009287|UniProtKB=O93602	Cyclic AMP-dependent transcription factor ATF-2	IDA	10207617	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P04393	Ras Pathway	P04557	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00005	Angiogenesis	P00200	Dsh	BOVIN|Ensembl=ENSBTAG00000019336|UniProtKB=F1MMW6	Uncharacterized protein	ISS	11212302	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IC	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00057	Wnt signaling pathway	P01472	Histone deacetylase	ANOGA|EnsemblGenome=AGAP006511|UniProtKB=Q7Q5D2	Histone deacetylase	ISS	10485845	PubMed	PTHR10625:SF171	HISTONE DEACETYLASE 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	ARATH|TAIR=AT2G18170|UniProtKB=Q39027	Mitogen-activated protein kinase 7	TAS			PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	11591316	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	9754712	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CHICK|Ensembl=ENSGALG00000012894|UniProtKB=P30372	Muscarinic acetylcholine receptor M2	IDA	10069496	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00010	B cell activation	P00385	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	IGI	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00009	Axon guidance mediated by netrin	P00364	cdc42	ASHGO|EnsemblGenome=AGOS_AGL093W|UniProtKB=Q9HF56	Cell division control protein 42	ISS	12932731	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	LEIMA|EnsemblGenome=LmjF.36.1260|UniProtKB=Q4Q1V0	Fructose-bisphosphate aldolase	ISS	20017533	PubMed	PTHR11627:SF20	FRUCTOSE-BISPHOSPHATE ALDOLASE
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01202	p85	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	IDA	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00023	General transcription regulation	P00660	RNA Polymerase II	NEUCR|EnsemblGenome=EFNCRG00000001712|UniProtKB=Q1K5K1	DNA-directed RNA polymerase II polypeptide	ISS	2187864	PubMed	PTHR11800:SF2	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00205	GAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	14707121	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05731	GABA-B receptor II signaling	P05754	Ggamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	HUMAN|HGNC=19663|UniProtKB=Q9UBI6	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IDA			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00007	Axon guidance mediated by semaphorins	P00331	PAK	RAT|RGD=3250|UniProtKB=P35465	Serine/threonine-protein kinase PAK 1	ISS	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	HUMAN|HGNC=4579|UniProtKB=P39086	Glutamate receptor ionotropic, kainate 1	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00398	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IGI	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04651	Ras	PANTR|Ensembl=ENSPTRG00000004775|UniProtKB=H2Q5M1	Uncharacterized protein	ISS	6287573	PubMed	PTHR24070:SF186	GTPASE KRAS
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00006	Apoptosis signaling pathway	P00310	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	G06682	Isl-1	RAT|RGD=61957|UniProtKB=P61374	Insulin gene enhancer protein ISL-1	RCA			PTHR24204:SF3	INSULIN GENE ENHANCER PROTEIN ISL-1
P00048	PI3 kinase pathway	P01179	PKB	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	IDA	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00050	Plasminogen activating cascade	P01263	pro-MMP-1	MACMU|Ensembl=ENSMMUG00000002037|UniProtKB=F6WYF2	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF151	INTERSTITIAL COLLAGENASE
P00049	Parkinson disease	P01242	Casein kinase I	CAEEL|WormBase=WBGene00002202|UniProtKB=P42168	Casein kinase I isoform alpha	ISS	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	TAS	89186920	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00029	Huntington disease	P00780	Microtubule	DAPPU|EnsemblGenome=DAPPUDRAFT_302845|UniProtKB=E9GER1	Putative uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00059	p53 pathway	P04633	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_127489|UniProtKB=C3XYC6	Putative uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000002339|UniProtKB=H2R368	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00976	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IPI	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01411	Ras	PANTR|Ensembl=ENSPTRG00000034469|UniProtKB=H2Q2V0	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00053	T cell activation	P01305	Calmodulin	BOVIN|Ensembl=ENSBTAG00000014583|UniProtKB=P62157	Calmodulin	ISS	9753452	PubMed	PTHR23050:SF335	CALMODULIN, STRIATED MUSCLE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	8787761	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01152	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	88318957	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	PANTR|Ensembl=ENSPTRG00000004701|UniProtKB=H2Q5G9	Low density lipoprotein receptor-related protein 6	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00057	Wnt signaling pathway	P01438	PP2A	HUMAN|HGNC=9299|UniProtKB=P67775	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00471	Cadherin	BOVIN|Ensembl=ENSBTAG00000018804|UniProtKB=E1BJ11	Uncharacterized protein	ISS	8120095	PubMed	PTHR24026:SF32	CADHERIN EGF LAG SEVEN-PASS G-TYPE RECEPTOR 2
P00018	EGF receptor signaling pathway	P00561	STAT	HUMAN|HGNC=11362|UniProtKB=P42224	Signal transducer and activator of transcription 1-alpha/beta	IGI	15825084	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P04393	Ras Pathway	P04579	Shc	BOVIN|Ensembl=ENSBTAG00000019838|UniProtKB=Q0IIE2	SHC-transforming protein 1	ISS	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	MOUSE|MGI=MGI=1859547|UniProtKB=Q9R0N3	Synaptotagmin-11	RCA			PTHR10024:SF115	SYNAPTOTAGMIN-11
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	METJA|EnsemblGenome=MJ_0561|UniProtKB=Q57981	Adenylosuccinate synthetase	IEP	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00048	PI3 kinase pathway	P01188	Gbetagamma	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000000365|UniProtKB=F6R9F4	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00010	B cell activation	P00383	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00005	Angiogenesis	P00219	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	PHANO|EnsemblGenome=SNOG_12991|UniProtKB=Q0U5H3	Uncharacterized protein	ISS			PTHR24072:SF192	CDC42 HOMOLOG
P00020	FAS signaling pathway	P00616	Nuclear Lamin	CAEBR|Gene=CBG12363|UniProtKB=A8XF91	Protein CBR-LMN-1	ISS	11165516	PubMed	PTHR23239:SF234	LAMIN DM0-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00056	VEGF signaling pathway	P01415	MAPKAPK2/3	HUMAN|HGNC=6888|UniProtKB=Q16644	MAP kinase-activated protein kinase 3	IDA	11157753	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	MACMU|Ensembl=ENSMMUG00000004657|UniProtKB=G7MVY8	Furin	ISS	10956649	PubMed	PTHR42884:SF1	FURIN
P04393	Ras Pathway	P04573	Elk-1	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	IDA	12660819	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00021	FGF signaling pathway	P00631	Grb2	RAT|RGD=1306884|UniProtKB=Q4KM68	GRB2-related adaptor protein	ISS	51702266	gi	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P00018	EGF receptor signaling pathway	P00543	ERK1-2	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	IGI	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P02754	Methylcitrate cycle	P03028	Aconitase	STRCO|Gene=CAC37548|UniProtKB=Q7AKF3	Aconitate hydratase	ISS			PTHR11670:SF1	ACONITATE HYDRATASE
P05918	p38 MAPK pathway	P06020	p38delta	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	RCA	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00059	p53 pathway	G04703	Apaf	MOUSE|MGI=MGI=1306796|UniProtKB=O88879	Apoptotic protease-activating factor 1	ISS	14526190	PubMed	PTHR22845:SF5	APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
P00006	Apoptosis signaling pathway	P00269	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	12657601	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	CHICK|Ensembl=ENSGALG00000002639|UniProtKB=Q6DMS2	Transient receptor potential cation channel subfamily C member 1 isoform alpha	IDA	11055438	PubMed	PTHR10117:SF56	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 1
P00020	FAS signaling pathway	P00622	FADD	HUMAN|HGNC=3573|UniProtKB=Q13158	FAS-associated death domain protein	IGI	9506948	PubMed	PTHR15077:SF8	FAS-ASSOCIATED DEATH DOMAIN PROTEIN
P05730	Endogenous cannabinoid signaling	P05746	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00010	B cell activation	P00385	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	MACMU|Ensembl=ENSMMUG00000010269|UniProtKB=F6PVP0	Uncharacterized protein	ISS			PTHR11405:SF5	CAD PROTEIN
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	DANRE|ZFIN=ZDB-GENE-040808-67|UniProtKB=Q6AZA4	K-ras	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00054	Toll receptor signaling pathway	P01375	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00036	Interleukin signaling pathway	P00990	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06959	CCKR signaling map	P07114	JUN	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	RCA	20637111	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	IDA	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	CAEEL|WormBase=WBGene00011867|UniProtKB=P34574	Probable clathrin heavy chain 1	IDA	9388255	PubMed	PTHR10292:SF1	CLATHRIN HEAVY CHAIN
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	RAT|RGD=1586637|UniProtKB=F1LMY4	Ryanodine receptor 1	ISS	15226293	PubMed	PTHR13715:SF15	RYANODINE RECEPTOR 1
P00045	Notch signaling pathway	P01099	Notch	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00010	B cell activation	P00392	I kappa B	MACMU|Ensembl=ENSMMUG00000020374|UniProtKB=F6UMS2	NF-kappa-B inhibitor alpha	ISS	10811867	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00019	Endothelin signaling pathway	P00587	Raf-1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00005	Angiogenesis	P00237	FRP	PANTR|Ensembl=ENSPTRG00000028511|UniProtKB=H2R570	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF81	FRIZZLED-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00021	FGF signaling pathway	P00642	MEK1-2	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IGI	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MACMU|Ensembl=ENSMMUG00000005185|UniProtKB=F7CYN6	Uncharacterized protein	ISS	9774420	PubMed	PTHR10845:SF184	REGULATOR OF G-PROTEIN SIGNALING 4
P00006	Apoptosis signaling pathway	P00269	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_60743|UniProtKB=C3XYD4	Putative uncharacterized protein	ISS			PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000004168|UniProtKB=H2R0J8	Uncharacterized protein	ISS	8120095	PubMed	PTHR24026:SF49	PROTOCADHERIN FAT 3
P00047	PDGF signaling pathway	P01161	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00021	FGF signaling pathway	P00648	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00034	Integrin signalling pathway	P00922	Collagen	CANLF|Ensembl=ENSCAFG00000002589|UniProtKB=F1PPQ7	Uncharacterized protein	ISS	10778855	PubMed	PTHR44652:SF3	COLLAGEN ALPHA-1 IX  CHAIN
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04393	Ras Pathway	P04542	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01206	14-3-3	BOVIN|Ensembl=ENSBTAG00000000236|UniProtKB=P63103	14-3-3 protein zeta/delta	ISS	12615066	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00057	Wnt signaling pathway	P01451	Galpha	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	IDA	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00019	Endothelin signaling pathway	P00586	Gq	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	TAS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00543	ERK1-2	LEIMA|EnsemblGenome=LmjF.10.0490|UniProtKB=Q4QHG6	Mitogen-activated protein kinase	ISS			PTHR24055:SF234	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00021	FGF signaling pathway	P00644	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IGI	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00053	T cell activation	P01312	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	XENTR|Xenbase=XB-GENE-493937|UniProtKB=Q5M8T9	Actin, alpha 2, smooth muscle, aorta	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00020	FAS signaling pathway	P00593	Caspase9	RAT|RGD=61867|UniProtKB=Q9JHK1	Caspase	IGI	9390557	PubMed	PTHR10454:SF157	CASPASE-9
P00018	EGF receptor signaling pathway	P00545	JNK1-3	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	ARATH|TAIR=AT5G61210|UniProtKB=Q9S7P9	SNAP25 homologous protein SNAP33	ISS			PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	BOVIN|Ensembl=ENSBTAG00000005464|UniProtKB=E1B9K3	Uncharacterized protein	ISS	92409599	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MOUSE|MGI=MGI=102522|UniProtKB=Q8R3Z5	Voltage-dependent L-type calcium channel subunit beta-1	IC	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00050	Plasminogen activating cascade	P01246	Plasmin	PANTR|Ensembl=ENSPTRG00000018774|UniProtKB=H2QU06	Plasminogen	ISS	4505881	gi	PTHR24261:SF6	PLASMINOGEN
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00010	B cell activation	P00398	IP3R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04393	Ras Pathway	P04557	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00034	Integrin signalling pathway	P00920	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00024	Glycolysis	P00671	Phosphoglycerate kinase	HUMAN|HGNC=8896|UniProtKB=P00558	Phosphoglycerate kinase 1	ISS	79199779	PubMed	PTHR11406:SF14	PHOSPHOGLYCERATE KINASE 1
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00965	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02762	Pentose phosphate pathway	P03070	Gluconate Dehydrogenase	ORNAN|Ensembl=ENSOANG00000002801|UniProtKB=F7AC35	6-phosphogluconate dehydrogenase, decarboxylating	ISS	8978909	PubMed	PTHR11811:SF25	6-PHOSPHOGLUCONATE DEHYDROGENASE, DECARBOXYLATING
P05913	Enkephalin release	P05972	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00029	Huntington disease	P00769	N-Wasp	BOVIN|Ensembl=ENSBTAG00000004643|UniProtKB=Q95107	Neural Wiskott-Aldrich syndrome protein	TAS	12932731	PubMed	PTHR23202:SF39	NEURAL WISKOTT-ALDRICH SYNDROME PROTEIN
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	PANTR|Ensembl=ENSPTRG00000005449|UniProtKB=H2Q6V7	Serine/threonine-protein phosphatase	ISS	10433257	PubMed	PTHR11668:SF377	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-ALPHA CATALYTIC SUBUNIT
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	XENTR|Xenbase=XB-GENE-960148|UniProtKB=F6XMD3	Protein Wnt (Fragment)	ISS	11266476	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00029	Huntington disease	P00799	JNK-2	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00048	PI3 kinase pathway	P01181	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00012	Cadherin signaling pathway	P00469	Fer	MACMU|Ensembl=ENSMMUG00000013582|UniProtKB=F7GUD3	Tyrosine-protein kinase	ISS	9742093	PubMed	PTHR24418:SF227	TYROSINE-PROTEIN KINASE FER
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-040426-2427|UniProtKB=F1Q6C0	Uncharacterized protein (Fragment)	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00960	PTP	PANTR|Ensembl=ENSPTRG00000004601|UniProtKB=H2R7K2	Tyrosine-protein phosphatase non-receptor type	ISS	14525967	PubMed	PTHR19134:SF65	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 6
P00029	Huntington disease	P00805	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02726	Aminobutyrate degradation	P02825	4-aminobutyrate aminotransferase	BACSU|EnsemblGenome=BSU03900|UniProtKB=P94427	Probable 4-aminobutyrate aminotransferase	ISS			PTHR43206:SF2	4-AMINOBUTYRATE AMINOTRANSFERASE GABT
P00006	Apoptosis signaling pathway	P00274	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	TAS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00020	FAS signaling pathway	P00600	PARP	PANTR|Ensembl=ENSPTRG00000014981|UniProtKB=H2QMQ4	Poly [ADP-ribose] polymerase	ISS	12101391	PubMed	PTHR10459:SF66	POLY  ADP-RIBOSE  POLYMERASE 3
P00056	VEGF signaling pathway	P01414	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00025	Hedgehog signaling pathway	P00692	GSK3	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04393	Ras Pathway	P04569	Cdc42	ASHGO|EnsemblGenome=AGOS_AGL093W|UniProtKB=Q9HF56	Cell division control protein 42	ISS	12932731	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P02732	Coenzyme A linked carnitine metabolism	P02864	L-carnitine dehydratase	STRCO|Gene=CAB52867|UniProtKB=Q9S2Y3	Uncharacterized protein	ISS			PTHR43949:SF1	ACETYL-COA:OXALATE COA-TRANSFERASE
P00054	Toll receptor signaling pathway	P01358	ERK1	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00568	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00036	Interleukin signaling pathway	P00986	eNOS	BOVIN|Gene=NOS3|UniProtKB=P29473	Nitric oxide synthase, endothelial	ISS	9837777	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00036	Interleukin signaling pathway	P00973	PKB	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00053	T cell activation	P01315	Calcineurin	BOVIN|Ensembl=ENSBTAG00000016005|UniProtKB=P48452	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	IGI	7532676	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00470	F-actin	CANLF|Ensembl=ENSCAFG00000012181|UniProtKB=F2Z4N7	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00012	Cadherin signaling pathway	P00471	Cadherin	XENTR|Xenbase=XB-GENE-1011620|UniProtKB=F7BBY2	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF84	CADHERIN-20
P00021	FGF signaling pathway	P00634	MEKK1-5	CANLF|Ensembl=ENSCAFG00000012934|UniProtKB=F1P750	Uncharacterized protein	ISS	9006902	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00034	Integrin signalling pathway	P00950	Paxillin	RAT|RGD=1305759|UniProtKB=Q66H76	Paxillin	ISS	9182576	PubMed	PTHR24216:SF11	PAXILLIN
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	DICDI|dictyBase=DDB_G0272110|UniProtKB=P51136	Glycogen synthase kinase-3	IDA	12615961	PubMed	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	HUMAN|HGNC=4616|UniProtKB=P49840	Glycogen synthase kinase-3 alpha	TAS	2164470	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	BACSU|EnsemblGenome=BSU20040|UniProtKB=O30601	SPBc2 prophage-derived ribonucleoside-diphosphate reductase subunit beta	ISS			PTHR23409:SF32	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00057	Wnt signaling pathway	P01465	Ggamma	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00046	Oxidative stress response	P01125	Stat1	TAKRU|Ensembl=ENSTRUG00000000102|UniProtKB=H2RJA9	Signal transducer and activator of transcription	ISS	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	ARATH|TAIR=AT1G13890|UniProtKB=Q9LMG8	Putative SNAP25 homologous protein SNAP30	IC			PTHR19305:SF7	SNAP25 HOMOLOGOUS PROTEIN SNAP30-RELATED
P00030	Hypoxia response via HIF activation	P00819	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	ISS	11889126	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IDA	1504106	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01023	CaMKII	MACMU|Ensembl=ENSMMUG00000021393|UniProtKB=F7FD86	Calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 1	ISS	12888804	PubMed	PTHR43940:SF7	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT GAMMA
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	RCA	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IDA	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MACMU|Ensembl=ENSMMUG00000010440|UniProtKB=F7CRV6	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00052	TGF-beta signaling pathway	P01288	FKBP12	MOUSE|MGI=MGI=95541|UniProtKB=P26883	Peptidyl-prolyl cis-trans isomerase FKBP1A	ISS			PTHR10516:SF301	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	TAS			PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00006	Apoptosis signaling pathway	P00259	TNF	BOVIN|Ensembl=ENSBTAG00000000016|UniProtKB=Q06600	Lymphotoxin-alpha	ISS			PTHR11471:SF31	LYMPHOTOXIN-ALPHA
P00001	Adrenaline and noradrenaline biosynthesis	P00068	amine translocator	MACMU|Ensembl=ENSMMUG00000010935|UniProtKB=F7GJ89	Transporter	ISS	12719981	PubMed	PTHR11616:SF125	SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER B 0 AT1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	METAC|EnsemblGenome=MA_0179|UniProtKB=Q8TU94	TATA-box-binding protein 2	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000022175|UniProtKB=F6XHY0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347736|UniProtKB=E9FRT1	Muscle-specific actin	ISS	11889126	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00005	Angiogenesis	P00243	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=4594|UniProtKB=Q14416	Metabotropic glutamate receptor 2	IDA	12488551	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P05912	Dopamine receptor mediated signaling pathway	P05968	CLIC6	RAT|RGD=727938|UniProtKB=Q811Q2	Chloride intracellular channel protein 6	IPI	14499480	PubMed	PTHR45476:SF1	CHLORIDE INTRACELLULAR CHANNEL PROTEIN 6
P00021	FGF signaling pathway	P00629	PP2A	TRIAD|EnsemblGenome=TriadG63380|UniProtKB=B3S653	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00927	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2057|UniProtKB=P19328	Alpha-2B adrenergic receptor	IDA	11781138	PubMed	PTHR24248:SF26	ALPHA-2B ADRENERGIC RECEPTOR
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00052	TGF-beta signaling pathway	P01275	P38	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=107451|UniProtKB=Q8K2J0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3	ISS	12860966	PubMed	PTHR10336:SF33	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-3
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P06959	CCKR signaling map	G07286	BIRC3	HUMAN|HGNC=591|UniProtKB=Q13489	Baculoviral IAP repeat-containing protein 3	RCA	17704804	PubMed	PTHR10044:SF99	BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 3
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000001583|UniProtKB=F7BBM1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00021	FGF signaling pathway	P00627	ERK1-2	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IDA	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Gene=HTR1F|UniProtKB=Q9N2D9	5-hydroxytryptamine receptor 1F (Fragment)	IDA	1608964	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TAKRU|Ensembl=ENSTRUG00000004787|UniProtKB=P53480	Actin, alpha cardiac	IC	11889126	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00047	PDGF signaling pathway	P01171	PLCgamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00047	PDGF signaling pathway	P01152	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	11847220	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00059	p53 pathway	P01486	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	PANTR|Ensembl=ENSPTRG00000014760|UniProtKB=H2QMB3	Serine/threonine-protein kinase receptor	ISS	11252892	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P00004	Alzheimer disease-presenilin pathway	P00149	Pen-2	MOUSE|MGI=MGI=1913590|UniProtKB=Q9CQR7	Gamma-secretase subunit PEN-2	IDA	12110170	PubMed	PTHR16318:SF0	GAMMA-SECRETASE SUBUNIT PEN-2
P04393	Ras Pathway	P04566	Stat 1/3	BOVIN|Gene=STAT3|UniProtKB=P61635	Signal transducer and activator of transcription 3	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	ANOGA|EnsemblGenome=AGAP006521|UniProtKB=Q7Q5C3	AGAP006521-PA	IC			PTHR10218:SF229	GUANINE NUCLEOTIDE-BINDING PROTEIN G F  SUBUNIT ALPHA
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	MOUSE|MGI=MGI=1346037|UniProtKB=Q9WTL4	Insulin receptor-related protein	ISS	11182407	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P04398	p53 pathway feedback loops 2	P04665	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04566	Stat 1/3	BOVIN|Gene=STAT3|UniProtKB=P61635	Signal transducer and activator of transcription 3	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	TAS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05913	Enkephalin release	P05974	G-Protein (i)	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	MOUSE|MGI=MGI=88276|UniProtKB=Q02248	Catenin beta-1	TAS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2343|UniProtKB=P08483	Muscarinic acetylcholine receptor M3	IDA			PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00951	Jnk	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00059	p53 pathway	P04630	PP2A	BOVIN|Ensembl=ENSBTAG00000000469|UniProtKB=P67774	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Ensembl=ENSCAFG00000009203|UniProtKB=F1PVZ1	Muscarinic acetylcholine receptor	ISS	12181435	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00046	Oxidative stress response	P01131	MKP5	ORNAN|Ensembl=ENSOANG00000001348|UniProtKB=F7F2Q8	Uncharacterized protein	ISS			PTHR10159:SF385	SERINE/THREONINE/TYROSINE-INTERACTING PROTEIN
P00047	PDGF signaling pathway	P01175	Shc	CANLF|Ensembl=ENSCAFG00000002201|UniProtKB=F1PPW0	Uncharacterized protein	ISS	96330343	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P00036	Interleukin signaling pathway	P00990	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00053	T cell activation	P01335	jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	P17325	SPACC	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00034	Integrin signalling pathway	P00938	Cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00054	Toll receptor signaling pathway	P01358	ERK1	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02751	Lysine biosynthesis	P03007	Diaminopimelate decarboxylase	THEMA|EnsemblGenome=TM_1517|UniProtKB=Q9X1K5	Diaminopimelate decarboxylase	ISS			PTHR43727:SF2	DIAMINOPIMELATE DECARBOXYLASE 1, CHLOROPLASTIC-RELATED
P04393	Ras Pathway	P04552	SOS	DROME|FlyBase=FBgn0001965|UniProtKB=P26675	Protein son of sevenless	ISS	476780	gi	PTHR23113:SF99	PROTEIN SON OF SEVENLESS
P00011	Blood coagulation	P00411	PAI-1	MACMU|Ensembl=ENSMMUG00000009926|UniProtKB=F6Y5D7	Uncharacterized protein	ISS	189578	gi	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	HUMAN|HGNC=3020|UniProtKB=P21728	D(1A) dopamine receptor	ISS	11248120	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00029	Huntington disease	P00796	Kainate receptor	RAT|RGD=71027|UniProtKB=P42264	Glutamate receptor ionotropic, kainate 3	IDA	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P05734	Synaptic vesicle trafficking	P05778	SNAP-25	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	DROME|FlyBase=FBgn0023179|UniProtKB=Q9VBC7	Amontillado	IDA			PTHR42884:SF13	NEUROENDOCRINE CONVERTASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	BOVIN|Ensembl=ENSBTAG00000013790|UniProtKB=E1B847	Uncharacterized protein	ISS	8940199	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00059	p53 pathway	P01486	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00637	MKK4,7	CANLF|Ensembl=ENSCAFG00000017851|UniProtKB=F1PBB6	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P02728	Arginine biosynthesis	P02846	Ornithine carbamoyl transferase	CHICK|Gene=OTC|UniProtKB=Q9YHY9	Ornithine carbamoyltransferase, mitochondrial	ISS			PTHR11405:SF1	ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL
P00012	Cadherin signaling pathway	P00474	Wnt	CAEBR|Gene=CBG03476|UniProtKB=A8WV58	Protein CBR-EGL-20	ISS	8717036	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P06664	Gonadotropin-releasing hormone receptor pathway	P06742	NF-Y	MOUSE|MGI=MGI=97316|UniProtKB=P23708	Nuclear transcription factor Y subunit alpha	RCA			PTHR12632:SF6	NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05925	beta-ARR1	DANRE|ZFIN=ZDB-GENE-060824-1|UniProtKB=C3PTE8	Beta-arrestin 1	ISS	9388255	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	DROME|Gene=Dmel_CG7904|UniProtKB=A0A0B4KG59	Serine/threonine-protein kinase receptor	TAS	9395284	PubMed	PTHR23255:SF70	SERINE/THREONINE-PROTEIN KINASE RECEPTOR
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04393	Ras Pathway	P04565	MKK4/7	MOUSE|MGI=MGI=1346871|UniProtKB=Q8CE90	Dual specificity mitogen-activated protein kinase kinase 7	IDA	15039780	PubMed	PTHR24361:SF387	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7
P00034	Integrin signalling pathway	P00931	Integrin beta	MOUSE|MGI=MGI=96612|UniProtKB=O54890	Integrin beta-3	IDA	4206165	gi	PTHR10082:SF25	INTEGRIN BETA-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=17175|UniProtKB=Q9P212	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	12176394	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00021	FGF signaling pathway	P00648	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	BOVIN|Ensembl=ENSBTAG00000011579|UniProtKB=F1N5C5	Muscarinic acetylcholine receptor	ISS	11166329	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00006	Apoptosis signaling pathway	P00302	ATF	HUMAN|HGNC=784|UniProtKB=P15336	Cyclic AMP-dependent transcription factor ATF-2	ISS	10207617	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00047	PDGF signaling pathway	P01154	Ras	ORNAN|Ensembl=ENSOANG00000008835|UniProtKB=F7FR08	Uncharacterized protein	ISS	13679859	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04393	Ras Pathway	P04552	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	IDA	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=5291|UniProtKB=P28566	5-hydroxytryptamine receptor 1E	IDA	12181435	PubMed	PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	TAS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	ISS			PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02783	Tryptophan biosynthesis	P03206	Anthranilate synthase	LEPIN|EnsemblGenome=LA_3629|UniProtKB=Q8F067	Anthranilate synthase component II	RCA			PTHR43418:SF4	MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IDA	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00898	FKHR	MACMU|Ensembl=ENSMMUG00000030780|UniProtKB=F6ZVZ0	Uncharacterized protein	TAS			PTHR11829:SF159	FORKHEAD BOX PROTEIN O1
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	CHICK|Ensembl=ENSGALG00000006576|UniProtKB=E1BUE5	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00036	Interleukin signaling pathway	P00990	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00024	Glycolysis	P00680	Phosphoglyceromutase	BOVIN|Ensembl=ENSBTAG00000037625|UniProtKB=E1B959	Uncharacterized protein	ISS	2542247	PubMed	PTHR11931:SF11	BISPHOSPHOGLYCERATE MUTASE
P05918	p38 MAPK pathway	P06021	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12874273	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00048	PI3 kinase pathway	P01198	FOXO	HUMAN|HGNC=3821|UniProtKB=O43524	Forkhead box protein O3	TAS	14775847	gi	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00047	PDGF signaling pathway	P01161	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_126324|UniProtKB=C3XYC2	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04395	Vasopressin synthesis	P04590	Vasopressin	MOUSE|MGI=MGI=97453|UniProtKB=P35454	Oxytocin-neurophysin 1	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00030	Hypoxia response via HIF activation	P00819	AKT	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	TAS	95181376	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00050	Plasminogen activating cascade	P01255	Plasminogen	MOUSE|MGI=MGI=97620|UniProtKB=P20918	Plasminogen	ISS	16758216	gi	PTHR24261:SF5	PLASMINOGEN
P06959	CCKR signaling map	P07108	Caspase-3	HUMAN|HGNC=1504|UniProtKB=P42574	Caspase-3	RCA	12674216	PubMed	PTHR10454:SF198	CASPASE-3
P00056	VEGF signaling pathway	P01414	PLC-gamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00054	Toll receptor signaling pathway	P01355	AP1	XENTR|Xenbase=XB-GENE-482228|UniProtKB=F6RYL1	Uncharacterized protein	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00053	T cell activation	P01307	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P02746	Heme biosynthesis	P02973	Uroporphyrinogen methyltransferase	STRCO|Gene=CAB76072|UniProtKB=Q9L1C9	Putative uroporphyrin-III methyltransferase	ISS			PTHR21091:SF16	SIROHEME SYNTHASE
P00053	T cell activation	P01307	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00029	Huntington disease	P00805	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IDA	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	G01579	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	BOVIN|Ensembl=ENSBTAG00000014638|UniProtKB=F1N3B2	Uncharacterized protein	ISS	11055438	PubMed	PTHR10117:SF9	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 7
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF31	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	DANRE|ZFIN=ZDB-GENE-030131-7595|UniProtKB=Q6PBR4	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	TAS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CHICK|Ensembl=ENSGALG00000008586|UniProtKB=F1NYB1	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00021	FGF signaling pathway	P00641	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P02756	N-acetylglucosamine metabolism	P03038	N-acetylmannosamine kinase	ECOLI|EcoGene=EG12815|UniProtKB=P45425	N-acetylmannosamine kinase	ISS			PTHR18964:SF145	N-ACETYLMANNOSAMINE KINASE
P05918	p38 MAPK pathway	P05921	MKP5	ORNAN|Ensembl=ENSOANG00000001437|UniProtKB=F7GDU1	Uncharacterized protein	ISS	11856337	PubMed	PTHR10159:SF299	DUAL SPECIFICITY PROTEIN PHOSPHATASE 10
P04393	Ras Pathway	P04552	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00021	FGF signaling pathway	P00645	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00010	B cell activation	P00386	Calcineurin	MOUSE|MGI=MGI=107162|UniProtKB=P48455	Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform	IDA	12015605	PubMed	PTHR11668:SF186	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT GAMMA ISOFORM
P00056	VEGF signaling pathway	P01423	p38MAPK	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05731	GABA-B receptor II signaling	P05755	Gbeta	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	MACMU|Ensembl=ENSMMUG00000020878|UniProtKB=F7HL70	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform	ISS	1370475	PubMed	PTHR44087:SF2	PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, LIVER/TESTIS ISOFORM
P05731	GABA-B receptor II signaling	P05760	AC	MACMU|Ensembl=ENSMMUG00000002230|UniProtKB=F6W0C8	Uncharacterized protein	ISS			PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=3784|UniProtKB=P61265	Syntaxin-1B	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00006	Apoptosis signaling pathway	P00303	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	PANTR|Ensembl=ENSPTRG00000006342|UniProtKB=H2Q8A8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04398	p53 pathway feedback loops 2	P04651	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P00036	Interleukin signaling pathway	P00975	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	11847220	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	XENTR|Xenbase=XB-GENE-1012455|UniProtKB=F6TKH3	Uncharacterized protein (Fragment)	ISS			PTHR11824:SF7	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4
P00029	Huntington disease	P00797	p53	CHICK|Ensembl=ENSGALG00000003818|UniProtKB=F1NE09	Uncharacterized protein	ISS			PTHR12195:SF1	CYTOPLASMIC FMR1-INTERACTING PROTEIN 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	XENTR|Xenbase=XB-GENE-961282|UniProtKB=Q6DF43	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04393	Ras Pathway	P04568	MKK3/6	MACMU|Ensembl=ENSMMUG00000010904|UniProtKB=F7GLY5	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00568	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00012	Cadherin signaling pathway	P00464	Fyn	CHICK|Gene=FYN|UniProtKB=Q05876	Tyrosine-protein kinase Fyn	ISS	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00019	Endothelin signaling pathway	P00572	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10875333	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00006	Apoptosis signaling pathway	P00298	Caspase 9	PANTR|Ensembl=ENSPTRG00000000200|UniProtKB=H2PY35	Caspase	ISS	8663294	PubMed	PTHR10454:SF157	CASPASE-9
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PHYPA|Gene=PHYPADRAFT_198730|UniProtKB=Q6TYS2	Actin 1	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_188187|UniProtKB=E9GJ31	Guanine nucleotide binding protein, q polypeptide	ISS	8836152	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00050	Plasminogen activating cascade	P01257	tPA	MACMU|Ensembl=ENSMMUG00000014432|UniProtKB=F7BHV7	Tissue-type plasminogen activator	ISS	6572897	PubMed	PTHR44617:SF1	TISSUE-TYPE PLASMINOGEN ACTIVATOR
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	DANRE|ZFIN=ZDB-GENE-030131-6206|UniProtKB=F1Q5K4	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF676	MYOSIN, HEAVY POLYPEPTIDE 2, FAST MUSCLE SPECIFIC
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00215	Nck	CHICK|Ensembl=ENSGALG00000016799|UniProtKB=F1P4Q4	Uncharacterized protein	ISS	12874226	PubMed	PTHR44108:SF1	CYTOPLASMIC PROTEIN NCK2
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00029	Huntington disease	P00775	Rac	MOUSE|MGI=MGI=1928370|UniProtKB=P84096	Rho-related GTP-binding protein RhoG	TAS	4757952	gi	PTHR24072:SF158	RHO-RELATED GTP-BINDING PROTEIN RHOG
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_56687|UniProtKB=C3YC50	Putative uncharacterized protein	IC	3487386	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00012	Cadherin signaling pathway	P00475	Frizzled	DANRE|ZFIN=ZDB-GENE-000906-4|UniProtKB=B0S5E7	Frizzled homolog 9	IDA	8717036	PubMed	PTHR11309:SF79	FRIZZLED-9
P02736	Coenzyme A biosynthesis	P02885	Pantothenate kinase	BOVIN|Ensembl=ENSBTAG00000010442|UniProtKB=E1BCR9	Uncharacterized protein	ISS			PTHR12280:SF23	PANTOTHENATE KINASE 1
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12912997	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00048	PI3 kinase pathway	P01196	PDK1	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	IDA	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06849	Sos	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	RCA	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00056	VEGF signaling pathway	P01408	Akt/PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00049	Parkinson disease	P01238	14-3-3	XENTR|Xenbase=XB-GENE-970616|UniProtKB=Q6P4Z5	14-3-3 protein zeta	ISS	12861023	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P05913	Enkephalin release	P05972	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00035	Interferon-gamma signaling pathway	P00952	Jak2	CANLF|Ensembl=ENSCAFG00000002102|UniProtKB=E2RPW6	Tyrosine-protein kinase	ISS	22482294	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CHICK|Ensembl=ENSGALG00000014620|UniProtKB=F1N8P3	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	BOVIN|Ensembl=ENSBTAG00000009269|UniProtKB=F1MCM2	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000011231|UniProtKB=F6WXV4	Uncharacterized protein	ISS	11431030	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DROME|FlyBase=FBgn0000489|UniProtKB=P16912	Protein kinase DC2	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00754	PDEgamma	DANRE|ZFIN=ZDB-GENE-030904-1|UniProtKB=Q7ZVI5	Pde6g protein	ISS			PTHR12122:SF4	RETINAL ROD RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT GAMMA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	ANOGA|EnsemblGenome=AGAP000445|UniProtKB=Q7PRU8	AGAP000445-PA	IDA	12515326	PubMed	PTHR24246:SF27	ADENOSINE RECEPTOR A2A
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TAKRU|Ensembl=ENSTRUG00000005447|UniProtKB=P68142	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF354	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00115	Nicastrin	MACMU|Ensembl=ENSMMUG00000021856|UniProtKB=F7EHX8	Nicastrin	ISS	16096062	PubMed	PTHR21092:SF0	NICASTRIN
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	IDA	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01446	Calcineurin	BOVIN|Ensembl=ENSBTAG00000020133|UniProtKB=A5D7T5	Serine/threonine-protein phosphatase	ISS	12091710	PubMed	PTHR11668:SF186	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT GAMMA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00029	Huntington disease	P00796	Kainate receptor	MOUSE|MGI=MGI=95814|UniProtKB=Q60934	Glutamate receptor ionotropic, kainate 1	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	HUMAN|HGNC=4583|UniProtKB=Q16478	Glutamate receptor ionotropic, kainate 5	ISS	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CHICK|Gene=WNT2B|UniProtKB=Q98SN7	Protein Wnt-2b	TAS	8717036	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00004	Alzheimer disease-presenilin pathway	P00114	actin	RAT|RGD=2025|UniProtKB=P68136	Actin, alpha skeletal muscle	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00010	B cell activation	P00388	PLC gamma2	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00006	Apoptosis signaling pathway	P00259	TNF	MACMU|Ensembl=ENSMMUG00000008849|UniProtKB=Q5TM22	Lymphotoxin-beta	ISS	1908877	PubMed	PTHR11471:SF29	LYMPHOTOXIN-BETA
P00053	T cell activation	P01336	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00010	B cell activation	P00369	MEKK	CANLF|Ensembl=ENSCAFG00000012934|UniProtKB=F1P750	Uncharacterized protein	ISS	9006902	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00018	EGF receptor signaling pathway	P00556	PLCgamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P02748	Isoleucine biosynthesis	P02995	Threonine dehydratase	BACSU|EnsemblGenome=BSU21770|UniProtKB=P37946	L-threonine dehydratase biosynthetic IlvA	ISS			PTHR43714:SF1	THREONINE DEHYDRATASE, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MONDO|Ensembl=ENSMODG00000000771|UniProtKB=F6SSS3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	XENTR|Xenbase=XB-GENE-963560|UniProtKB=Q0VFC4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	HUMAN|HGNC=1952|UniProtKB=P20309	Muscarinic acetylcholine receptor M3	ISS	12181435	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00006	Apoptosis signaling pathway	P00301	Apaf-1	BOVIN|Ensembl=ENSBTAG00000021661|UniProtKB=F1MUW4	Apoptotic protease-activating factor 1	ISS	10364241	PubMed	PTHR22845:SF5	APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
P00034	Integrin signalling pathway	P00912	Arp2/3	BOVIN|Ensembl=ENSBTAG00000046248|UniProtKB=Q58CQ2	Actin-related protein 2/3 complex subunit 1B	IPI	9618202	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MACMU|Ensembl=ENSMMUG00000007920|UniProtKB=F7HT21	Uncharacterized protein	ISS			PTHR13140:SF289	UNCONVENTIONAL MYOSIN-XIX
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	CANLF|Gene=PSEN1|UniProtKB=Q6RH31	Presenilin-1	ISS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P05918	p38 MAPK pathway	P06043	ASK1	MACMU|Ensembl=ENSMMUG00000016376|UniProtKB=F7G2W1	Uncharacterized protein	ISS	11730323	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00011	Blood coagulation	P00406	Fibrinogen	MACMU|Ensembl=ENSMMUG00000021304|UniProtKB=F6UYY8	Uncharacterized protein	ISS	80015086	PubMed	PTHR19143:SF338	FIBRINOGEN GAMMA CHAIN
P00018	EGF receptor signaling pathway	P00554	Shc	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	ISS	7680960	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00056	VEGF signaling pathway	P01408	Akt/PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	CHICK|Ensembl=ENSGALG00000002591|UniProtKB=F1NHV9	Uncharacterized protein	ISS			PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	IDA	11956331	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00114	actin	TAKRU|Ensembl=ENSTRUG00000005494|UniProtKB=P53483	Actin, alpha anomalous	IDA	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00009	Axon guidance mediated by netrin	P00366	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	15470041	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00019	Endothelin signaling pathway	P00568	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IGI	10395542	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00052	TGF-beta signaling pathway	P01275	P38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	TAS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00559	MEK1-2	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	METAC|EnsemblGenome=MA_3023|UniProtKB=Q8TLL3	Glutamine--fructose-6-phosphate aminotransferase [isomerizing]	ISS			PTHR10937:SF0	GH12731P-RELATED
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00190	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	14707121	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00036	Interleukin signaling pathway	P00990	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02751	Lysine biosynthesis	P03008	Dihydrodipicolinate synthase	SULSO|EnsemblGenome=SSO3072|UniProtKB=Q97UF0	Dihydrodipicolinate synthase (DapA-3)	ISS			PTHR12128:SF15	4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04393	Ras Pathway	P04547	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02740	De novo pyrimidine ribonucleotides biosythesis	P02928	Dihydroorotase	PSEAE|EnsemblGenome=PA0401|UniProtKB=Q51551	Dihydroorotase-like protein	ISS			PTHR43668:SF1	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	HUMAN|HGNC=4047|UniProtKB=O00144	Frizzled-9	TAS	11212302	PubMed	PTHR11309:SF79	FRIZZLED-9
P00019	Endothelin signaling pathway	P00590	IP3 R	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	14744428	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00557	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	IGI	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	PANTR|Ensembl=ENSPTRG00000007489|UniProtKB=H2QA49	Tyrosine-protein kinase receptor	ISS	11182407	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00056	VEGF signaling pathway	P01407	Erk	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	20384797	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00230	PDGFR	MOUSE|MGI=MGI=97530|UniProtKB=P26618	Platelet-derived growth factor receptor alpha	ISS	12374780	PubMed	PTHR24416:SF52	PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA
P00017	DNA replication	P00538	RNase H	SCHPO|PomBase=SPBC336.06c|UniProtKB=Q9UST8	Ribonuclease H	ISS	21848401	PubMed	PTHR10642:SF0	RIBONUCLEASE H1
P00056	VEGF signaling pathway	P01409	cPLA2	BOVIN|Ensembl=ENSBTAG00000013298|UniProtKB=A4IFJ5	Cytosolic phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P05731	GABA-B receptor II signaling	P05754	Ggamma	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00749	RGS9	PANTR|Ensembl=ENSPTRG00000009552|UniProtKB=H2QDP8	Uncharacterized protein	ISS	9459445	PubMed	PTHR10845:SF170	REGULATOR OF G-PROTEIN SIGNALING 9
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	DICDI|dictyBase=DDB_G0279413|UniProtKB=P05987	cAMP-dependent protein kinase regulatory subunit	IGI	176910	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01432	Beta-Catenin	MACMU|Ensembl=ENSMMUG00000014627|UniProtKB=F7GNE4	Catenin beta-1	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	10693759	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00029	Huntington disease	P00810	GAPDH	TRIVA|Gene=TVAG_412780|UniProtKB=A2GA05	Glyceraldehyde-3-phosphate dehydrogenase	IPI			PTHR43148:SF2	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE C-RELATED
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	METAC|EnsemblGenome=MA_2720|UniProtKB=Q8TMD8	Cysteine synthase	ISS			PTHR10314:SF159	CYSTEINE SYNTHASE A
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04393	Ras Pathway	P04560	AP1	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	TAS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01443	Phospholipase C	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00054	Toll receptor signaling pathway	P01369	MKK1	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00269	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P06664	Gonadotropin-releasing hormone receptor pathway	P06739	MEK1/2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	RCA	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	DANRE|ZFIN=ZDB-GENE-040108-1|UniProtKB=F1QKS3	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF535	SUBFAMILY NOT NAMED
P00017	DNA replication	P00527	Histones	ORNAN|Ensembl=ENSOANG00000000225|UniProtKB=F7CMG6	Histone H3	ISS	12413958	PubMed	PTHR11426:SF167	HISTONE H3.1
P00030	Hypoxia response via HIF activation	P00819	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P05731	GABA-B receptor II signaling	P05754	Ggamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	RCA	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P05916	Opioid prodynorphin pathway	P06002	G-protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00565	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00057	Wnt signaling pathway	P01438	PP2A	RAT|RGD=3381|UniProtKB=P62716	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MONDO|Ensembl=ENSMODG00000009618|UniProtKB=F6REU0	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00019	Endothelin signaling pathway	P00570	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00561	STAT	MACMU|Ensembl=ENSMMUG00000017527|UniProtKB=F6UMM2	Signal transducer and activator of transcription	ISS	8085155	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00054	Toll receptor signaling pathway	P01345	IKKalpha	RAT|RGD=1306661|UniProtKB=G3V926	Conserved helix-loop-helix ubiquitous kinase (Predicted)	ISS	14499113	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00896	Insulin IGF	CHICK|Ensembl=ENSGALG00000012755|UniProtKB=P18254	Insulin-like growth factor I	ISS			PTHR11454:SF4	INSULIN-LIKE GROWTH FACTOR I
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00221	JNK1	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00010	B cell activation	P00384	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Ensembl=ENSBTAG00000016187|UniProtKB=F1N213	Uncharacterized protein	ISS	11431030	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00057	Wnt signaling pathway	P01435	SWI/SNF	CANLF|Ensembl=ENSCAFG00000002013|UniProtKB=J9P5P2	Uncharacterized protein	ISS	11532957	PubMed	PTHR10799:SF541	GLOBAL TRANSCRIPTION ACTIVATOR SNF2L2-RELATED
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	RAT|RGD=69319|UniProtKB=P54313	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02916	dTMP kinase	MACMU|Ensembl=ENSMMUG00000008049|UniProtKB=F7H337	Uncharacterized protein	ISS			PTHR10344:SF1	THYMIDYLATE KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	PANTR|Ensembl=ENSPTRG00000006342|UniProtKB=H2Q8A8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	TAS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ORNAN|Ensembl=ENSOANG00000007581|UniProtKB=F6QWB7	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00015	Circadian clock system	P00505	Cry	HUMAN|HGNC=2384|UniProtKB=Q16526	Cryptochrome-1	IEP	10428031	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00021	FGF signaling pathway	P00629	PP2A	DANRE|ZFIN=ZDB-GENE-050417-441|UniProtKB=Q567Y8	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04393	Ras Pathway	P04572	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00029	Huntington disease	G01531	BDNF	ORNAN|Ensembl=ENSOANG00000013030|UniProtKB=O02795	Brain-derived neurotrophic factor (Fragment)	ISS	11408619	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00019	Endothelin signaling pathway	P00587	Raf-1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IGI	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CANLF|Ensembl=ENSCAFG00000010787|UniProtKB=E2R3W6	Uncharacterized protein	ISS	11248120	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00021	FGF signaling pathway	P00641	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02736	Coenzyme A biosynthesis	P02884	Dephospho-CoA kinase	ARATH|TAIR=AT2G27490|UniProtKB=Q9ZQH0	Dephospho-CoA kinase	ISS			PTHR10695:SF35	DEPHOSPHO-COA KINASE DOMAIN-CONTAINING PROTEIN
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00048	PI3 kinase pathway	P01188	Gbetagamma	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	6264430	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	CAEEL|WormBase=WBGene00000295|UniProtKB=Q9GNP0	Uncharacterized protein	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00020	FAS signaling pathway	P00615	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	RAT|RGD=2871|UniProtKB=G3V824	Insulin-like growth factor 2 receptor, isoform CRA_b	ISS	11081635	PubMed	PTHR15071:SF17	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
P06212	DPP-SCW signaling pathway	P06264	TLD	DROME|FlyBase=FBgn0003719|UniProtKB=P25723	Dorsal-ventral patterning protein tolloid	IDA	12925593	PubMed	PTHR43978:SF2	DORSAL-VENTRAL PATTERNING PROTEIN TOLLOID-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01395	TFIIE	RAT|RGD=1306851|UniProtKB=G3V992	General transcription factor II E, polypeptide 1 (Alpha subunit)	ISS	92065982	PubMed	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00049	Parkinson disease	P01236	Casein kinase II	CIOIN|Ensembl=ENSCING00000003902|UniProtKB=Q967X2	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00057	Wnt signaling pathway	P01444	Wnt	RAT|RGD=69346|UniProtKB=G3V7U3	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BOVIN|Ensembl=ENSBTAG00000005714|UniProtKB=Q3ZC07	Actin, alpha cardiac muscle 1	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04393	Ras Pathway	P04578	Rho	PANTR|Ensembl=ENSPTRG00000001112|UniProtKB=H2PZP2	Ras homolog gene family, member C	ISS	12090470	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00036	Interleukin signaling pathway	P00975	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	88318957	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04398	p53 pathway feedback loops 2	P04649	Myc	RAT|RGD=3130|UniProtKB=P09416	Myc proto-oncogene protein	TAS	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00021	FGF signaling pathway	P00637	MKK4,7	CHICK|Ensembl=ENSGALG00000001001|UniProtKB=F1P3T1	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DANRE|ZFIN=ZDB-GENE-040625-35|UniProtKB=Q6IQL9	Novel actin protein	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02757	O-antigen biosynthesis	P03045	dTDP-glucose 4,6-dehydratase	PANTR|Ensembl=ENSPTRG00000005967|UniProtKB=H2Q7P8	TDP-glucose 4,6-dehydratase	ISS			PTHR43000:SF7	DTDP-D-GLUCOSE 4,6-DEHYDRATASE
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00050	Plasminogen activating cascade	P01245	PAI-1	CANLF|Ensembl=ENSCAFG00000013909|UniProtKB=F1PUI4	Uncharacterized protein	ISS	1709561	gi	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00056	VEGF signaling pathway	P01407	Erk	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00048	PI3 kinase pathway	P01192	p110	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01161	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	CHICK|Ensembl=ENSGALG00000003806|UniProtKB=O93467	GTP-binding protein	ISS	12039949	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00010	B cell activation	P00402	Jnk	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04371	5-Hydroxytryptamine biosynthesis	P04399	Tryptophan hydroxylase	MACMU|Ensembl=ENSMMUG00000006096|UniProtKB=F7B7G4	Uncharacterized protein	ISS	14597720	PubMed	PTHR11473:SF23	TRYPTOPHAN 5-HYDROXYLASE 1
P05912	Dopamine receptor mediated signaling pathway	P05970	TH	DROME|FlyBase=FBgn0005626|UniProtKB=P18459	Tyrosine 3-monooxygenase	ISS	12480184	PubMed	PTHR11473:SF15	TYROSINE 3-MONOOXYGENASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00877	MLCK	PANTR|Ensembl=ENSPTRG00000008081|UniProtKB=H2QB15	Uncharacterized protein	ISS	600922	OMIM	PTHR45411:SF1	MYOSIN LIGHT CHAIN KINASE 3
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00019	Endothelin signaling pathway	P00587	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05972	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00005	Angiogenesis	P00221	JNK1	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00050	Plasminogen activating cascade	P01244	PAI-2	HUMAN|HGNC=8584|UniProtKB=P05120	Plasminogen activator inhibitor 2	IDA	11929770	PubMed	PTHR11461:SF61	PLASMINOGEN ACTIVATOR INHIBITOR 2
P00053	T cell activation	P01330	IKK	MOUSE|MGI=MGI=1338071|UniProtKB=O88351	Inhibitor of nuclear factor kappa-B kinase subunit beta	IGI	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DICDI|dictyBase=DDB_G0283907|UniProtKB=P34099	cAMP-dependent protein kinase catalytic subunit	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00057	Wnt signaling pathway	P01438	PP2A	MONDO|Ensembl=ENSMODG00000019001|UniProtKB=F7CP86	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P05731	GABA-B receptor II signaling	P05754	Ggamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	RCA	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00004	Alzheimer disease-presenilin pathway	P00114	actin	HUMAN|HGNC=169|UniProtKB=P61160	Actin-related protein 2	IDA	11889126	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P05917	Opioid proopiomelanocortin pathway	P06008	ACTH	BOVIN|Ensembl=ENSBTAG00000007897|UniProtKB=P01190	Pro-opiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=1306800|UniProtKB=Q7TSK3	Protocadherin-8	ISS	8120095	PubMed	PTHR24028:SF46	PROTOCADHERIN-8
P00005	Angiogenesis	P00223	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00023	General transcription regulation	P00660	RNA Polymerase II	BOVIN|Gene=POLR2F|UniProtKB=Q32PE0	DNA-directed RNA polymerases I, II, and III subunit RPABC2	ISS	415387	gi	PTHR10773:SF12	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	10218114	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00021	FGF signaling pathway	P00633	Ras	DAPPU|EnsemblGenome=DAPPUDRAFT_301818|UniProtKB=E9I1I7	Putative uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00048	PI3 kinase pathway	P01206	14-3-3	BOVIN|Ensembl=ENSBTAG00000000236|UniProtKB=P63103	14-3-3 protein zeta/delta	ISS	92283271	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	CANLF|Ensembl=ENSCAFG00000005449|UniProtKB=F1PNA9	TGF-beta receptor type-2	ISS	9395284	PubMed	PTHR23255:SF55	TGF-BETA RECEPTOR TYPE-2
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00047	PDGF signaling pathway	P01162	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04398	p53 pathway feedback loops 2	P04658	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00053	T cell activation	P01322	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04633	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00006	Apoptosis signaling pathway	P00269	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ORNAN|Ensembl=ENSOANG00000007716|UniProtKB=F6UDX9	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00046	Oxidative stress response	P01135	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	10074940	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01173	STAT	BOVIN|Gene=STAT5A|UniProtKB=Q95115	Signal transducer and activator of transcription 5A	ISS	8584036	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00029	Huntington disease	P00780	Microtubule	PLAF7|EnsemblGenome=PF10_0084|UniProtKB=Q7KQL5	Tubulin beta chain	IDA	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	IDA			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	HUMAN|HGNC=15906|UniProtKB=A7E2Y1	Myosin-7B	ISS	89264452	PubMed	PTHR13140:SF358	MYOSIN-7B
P04398	p53 pathway feedback loops 2	P04657	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P02788	Xanthine and guanine salvage pathway	P03249	Guanine deaminase	RAT|RGD=621617|UniProtKB=Q9WTT6	Guanine deaminase	ISS	7533042	gi	PTHR11271:SF6	GUANINE DEAMINASE
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	9199552	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00034	Integrin signalling pathway	P00951	Jnk	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	PANTR|Ensembl=ENSPTRG00000006342|UniProtKB=H2Q8A8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00049	Parkinson disease	P01208	Hsp70	SCHPO|PomBase=SPAC664.11|UniProtKB=P22774	Heat shock 70 kDa protein, mitochondrial	IDA	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00035	Interferon-gamma signaling pathway	P00956	SOCS	HUMAN|HGNC=19382|UniProtKB=O14508	Suppressor of cytokine signaling 2	ISS	15032587	PubMed	PTHR44396:SF2	SUPPRESSOR OF CYTOKINE SIGNALING 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01284	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00256	PLC-gamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00018	EGF receptor signaling pathway	P00557	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05730	Endogenous cannabinoid signaling	P05751	Galpha	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	MOUSE|MGI=MGI=1201678|UniProtKB=Q5SUF7	Protein Cacna1g	ISS	18021322	PubMed	PTHR10037:SF137	VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1G
P00010	B cell activation	P00375	Calmodulin	MONDO|Ensembl=ENSMODG00000004410|UniProtKB=F6SV58	Uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF322	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00780	Microtubule	IXOSC|EnsemblGenome=ISCW017136|UniProtKB=B7PA95	Beta tubulin	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000000289|UniProtKB=F7A9T0	Uncharacterized protein	ISS	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MOUSE|MGI=MGI=95790|UniProtKB=Q01776	Gonadotropin-releasing hormone receptor	IDA	12629106	PubMed	PTHR24241:SF22	GONADOTROPIN-RELEASING HORMONE RECEPTOR
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	CANLF|Ensembl=ENSCAFG00000002617|UniProtKB=E2QUL1	Uncharacterized protein	ISS	11319238	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05915	Opioid proenkephalin pathway	P05994	G-protein	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	HALSA|EnsemblGenome=VNG_0629G|UniProtKB=Q9HRM6	Aspartate aminotransferase	ISS			PTHR11751:SF306	SUBFAMILY NOT NAMED
P06211	BMP/activin signaling pathway-drosophila	P06252	SOG	DROME|FlyBase=FBgn0003463|UniProtKB=Q24025	Dorsal-ventral patterning protein Sog	IDA	16781701	PubMed	PTHR11339:SF357	DORSAL-VENTRAL PATTERNING PROTEIN SOG
P00045	Notch signaling pathway	P01104	Serrate	PANTR|Ensembl=ENSPTRG00000013250|UniProtKB=H2QJZ0	Delta-like protein	ISS	12826675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00005	Angiogenesis	P00245	Rac	DROME|FlyBase=FBgn0036257|UniProtKB=Q9VTU3	Rho GTPase-activating protein 68F	ISS			PTHR23176:SF0	RHO GTPASE-ACTIVATING PROTEIN 68F
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00021	FGF signaling pathway	P00630	RKIP	ANOGA|EnsemblGenome=AGAP013036|UniProtKB=F5HM76	AGAP013036-PA	ISS			PTHR11362:SF28	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P02738	De novo purine biosynthesis	P02898	Phosphoribosylformylglycinamide  synthase	PSEAE|EnsemblGenome=PA3763|UniProtKB=Q9HXN2	Phosphoribosylformylglycinamidine synthase	ISS			PTHR10099:SF5	PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	DICDI|dictyBase=DDB_G0279413|UniProtKB=P05987	cAMP-dependent protein kinase regulatory subunit	ISS	91072385	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	MACMU|Ensembl=ENSMMUG00000009607|UniProtKB=F7A586	5-hydroxytryptamine receptor 2C	ISS	12441358	PubMed	PTHR24247:SF32	5-HYDROXYTRYPTAMINE RECEPTOR 2C
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00644	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	ISS	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00010	B cell activation	P00383	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IDA	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MONDO|Ensembl=ENSMODG00000001303|UniProtKB=F7BZM9	Uncharacterized protein (Fragment)	ISS	12473693	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P05730	Endogenous cannabinoid signaling	P05748	mGluR	CHICK|Ensembl=ENSGALG00000017238|UniProtKB=F1NWG3	Uncharacterized protein	ISS	7476890	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MOUSE|MGI=MGI=1339712|UniProtKB=P13542	Myosin-8	ISS	89264452	PubMed	PTHR13140:SF368	MYOSIN-8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	CANLF|Ensembl=ENSCAFG00000005415|UniProtKB=F1PQM2	Uncharacterized protein	ISS	4757780	gi	PTHR11792:SF22	BETA-ARRESTIN-1
P02732	Coenzyme A linked carnitine metabolism	P02864	L-carnitine dehydratase	PSEAE|EnsemblGenome=PA0446|UniProtKB=Q9I672	Uncharacterized protein	ISS			PTHR43949:SF6	SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE
P00049	Parkinson disease	P01215	Syntaxin	MOUSE|MGI=MGI=1858210|UniProtKB=O70439	Syntaxin-7	ISS	10321247	PubMed	PTHR19957:SF90	SYNTAXIN-7
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	8387895	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00322	Cytochrome C	BOVIN|Ensembl=ENSBTAG00000022613|UniProtKB=P62894	Cytochrome c	ISS	5968568	PubMed	PTHR11961:SF15	CYTOCHROME C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00056	VEGF signaling pathway	P01408	Akt/PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00786	ARF	MONDO|Ensembl=ENSMODG00000023914|UniProtKB=F7FYA6	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00047	PDGF signaling pathway	P01142	p90RSK	MONDO|Ensembl=ENSMODG00000008086|UniProtKB=F6YJ34	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	IC	15313841	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00045	Notch signaling pathway	P01109	Aph-1	MACMU|Ensembl=ENSMMUG00000017856|UniProtKB=F7DK04	Uncharacterized protein	ISS	12763021	PubMed	PTHR12889:SF1	GAMMA-SECRETASE SUBUNIT APH-1B
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	IDA	10553940	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00057	Wnt signaling pathway	P01470	Frodo	MACMU|Ensembl=ENSMMUG00000001090|UniProtKB=F6QLT3	Uncharacterized protein	RCA			PTHR15919:SF12	DAPPER HOMOLOG 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000040329|UniProtKB=F1MMU1	Uncharacterized protein	ISS	14645495	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	CANLF|Ensembl=ENSCAFG00000024324|UniProtKB=E2QVZ3	Uncharacterized protein	ISS			PTHR12264:SF21	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BRAFL|Gene=BRAFLDRAFT_56711|UniProtKB=C3XPR5	Protein Wnt	TAS	11266476	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00055	Transcription regulation by bZIP transcription factor	P01392	TFIIH complex	BOVIN|Ensembl=ENSBTAG00000005160|UniProtKB=Q2KJ73	General transcription factor IIH, polypeptide 1, 62kDa	ISS			PTHR12856:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 1
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	DROME|FlyBase=FBgn0004396|UniProtKB=P29747	Cyclic AMP response element-binding protein A	ISS			PTHR22952:SF147	CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN A
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	DAPPU|EnsemblGenome=DAPPUDRAFT_223674|UniProtKB=E9GCV0	Putative uncharacterized protein	ISS	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00034	Integrin signalling pathway	P00947	Laminin	RAT|RGD=621023|UniProtKB=F1MAN8	Laminin, alpha 5, isoform CRA_a	ISS	2538453	PubMed	PTHR10574:SF261	LAMININ SUBUNIT ALPHA-5
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	PANTR|Ensembl=ENSPTRG00000013273|UniProtKB=H2QJZ8	Uncharacterized protein	ISS			PTHR42884:SF13	NEUROENDOCRINE CONVERTASE 2
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	DICPU|Gene=DICPUDRAFT_93216|UniProtKB=F1A421	Guanine nucleotide-binding protein subunit beta	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00046	Oxidative stress response	P01135	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00005	Angiogenesis	P00203	Erk	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	IGI	96149441	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00034	Integrin signalling pathway	P00925	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IDA	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05731	GABA-B receptor II signaling	P05755	Gbeta	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	DROME|FlyBase=FBgn0031437|UniProtKB=Q9VQD8	Actin-related protein 2/3 complex subunit 5	ISS	12473693	PubMed	PTHR12644:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00021	FGF signaling pathway	P00642	MEK1-2	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00034	Integrin signalling pathway	P00911	B-Raf	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	DROME|FlyBase=FBgn0004118|UniProtKB=P25162	Acetylcholine receptor subunit beta-like 2	IC	85270494	PubMed	PTHR18945:SF505	ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 2
P00018	EGF receptor signaling pathway	P00565	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00059	p53 pathway	P04625	Cdk2	STRPU|EnsemblGenome=SPU_007655|UniProtKB=W4XW48	Uncharacterized protein	ISS			PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04396	Vitamin D metabolism and pathway	P04608	24-Hydroxylase	MOUSE|MGI=MGI=88593|UniProtKB=Q64441	1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	IDA	11686044	PubMed	PTHR24291:SF5	1,25-DIHYDROXYVITAMIN D 3  24-HYDROXYLASE, MITOCHONDRIAL
P00036	Interleukin signaling pathway	P00973	PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01331	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IDA	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00625	MKK3,6	RAT|RGD=1306620|UniProtKB=B1H230	Map2k3 protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CAEEL|WormBase=WBGene00001187|UniProtKB=Q8MQA1	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00018	EGF receptor signaling pathway	P00554	Shc	PANTR|Ensembl=ENSPTRG00000021091|UniProtKB=H2QXF3	Uncharacterized protein	ISS	98175964	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IGI	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P02743	Formyltetrahydroformate biosynthesis	P02954	Thymidylate synthase	DANRE|ZFIN=ZDB-GENE-040426-59|UniProtKB=Q6P045	Tyms protein	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00005	Angiogenesis	P00219	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00898	FKHR	MACMU|Ensembl=ENSMMUG00000020369|UniProtKB=F6UMX8	Uncharacterized protein	ISS	10102273	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00057	Wnt signaling pathway	P01433	SIAH-1	ARATH|TAIR=AT5G37870|UniProtKB=Q9FKD9	Putative E3 ubiquitin-protein ligase SINA-like 6	ISS	11389839	PubMed	PTHR10315:SF43	E3 UBIQUITIN-PROTEIN LIGASE SINA-LIKE 1-RELATED
P04393	Ras Pathway	P04556	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	BOVIN|Ensembl=ENSBTAG00000021741|UniProtKB=F1MNR5	Ribosomal protein S6 kinase	ISS	1922062	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	YEAST|SGD=S000001612|UniProtKB=P36006	Myosin-3	IC			PTHR13140:SF663	HEAVY CHAIN, UNCONVENTIONAL MYOSIN
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Ensembl=ENSGALG00000028102|UniProtKB=F1P3X4	Uncharacterized protein	IEP	10938134	PubMed	PTHR13140:SF657	MYOSIN-4
P00021	FGF signaling pathway	P00627	ERK1-2	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00057	Wnt signaling pathway	P01428	Frizzled	DANRE|ZFIN=ZDB-GENE-990415-223|UniProtKB=Q6NV44	Frizzled homolog 7a	IDA	11212302	PubMed	PTHR11309:SF31	FRIZZLED-7
P06664	Gonadotropin-releasing hormone receptor pathway	P06769	Gbeta	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	RCA	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00010	B cell activation	P00398	IP3R	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00005	Angiogenesis	P00217	STAT3	PANTR|Ensembl=ENSPTRG00000009200|UniProtKB=H2QD20	Signal transducer and activator of transcription	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	TAS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01451	Galpha	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00557	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IGI	10799299	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00011	Blood coagulation	P00446	FVIIIa	HUMAN|HGNC=3546|UniProtKB=P00451	Coagulation factor VIII	ISS	4503647	gi	PTHR45309:SF1	COAGULATION FACTOR VIII
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00029	Huntington disease	P00780	Microtubule	PANTR|Ensembl=ENSPTRG00000017675|UniProtKB=H2QS81	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	DANRE|ZFIN=ZDB-GENE-990603-12|UniProtKB=O73864	Protein Wnt-11	TAS	11266476	PubMed	PTHR12027:SF34	PROTEIN WNT
P00053	T cell activation	P01331	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=4594|UniProtKB=Q14416	Metabotropic glutamate receptor 2	IDA	20012997	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00018	EGF receptor signaling pathway	P00548	RKIP	DROME|FlyBase=FBgn0038972|UniProtKB=Q9VD02	CG7054	ISS			PTHR11362:SF28	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	HUMAN|HGNC=4572|UniProtKB=P42262	Glutamate receptor 2	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00006	Apoptosis signaling pathway	P00313	IKK	MACMU|Ensembl=ENSMMUG00000018476|UniProtKB=F6X938	Uncharacterized protein	ISS	14499113	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P02772	Pyruvate metabolism	P03137	Citrate Lyase	CAEEL|WormBase=WBGene00007234|UniProtKB=Q93167	Uncharacterized protein	TAS			PTHR32308:SF0	CITRATE LYASE SUBUNIT BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	XENTR|Xenbase=XB-GENE-479036|UniProtKB=Q640R7	Ras-related protein Rap-1b	ISS	8576107	PubMed	PTHR24070:SF382	RAS-RELATED PROTEIN RAP-1B
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MONDO|Ensembl=ENSMODG00000010521|UniProtKB=F7DQK7	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00019	Endothelin signaling pathway	P00566	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01185	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	HUMAN|HGNC=4582|UniProtKB=Q16099	Glutamate receptor ionotropic, kainate 4	ISS	12871085	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P02772	Pyruvate metabolism	P03137	Citrate Lyase	RAT|RGD=2018|UniProtKB=P16638	ATP-citrate synthase	TAS			PTHR23118:SF0	ATP-CITRATE SYNTHASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	TAS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02724	Alanine biosynthesis	P02815	Branched chain amino acid aminotransferase	BACSU|EnsemblGenome=BSU38550|UniProtKB=P39576	Branched-chain-amino-acid aminotransferase 2	ISS			PTHR11825:SF44	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	IDA	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	PHYPA|Gene=PHYPADRAFT_145621|UniProtKB=A9THD0	Predicted protein	ISS	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P05915	Opioid proenkephalin pathway	P05989	leu-Enkephalin	HUMAN|HGNC=8831|UniProtKB=P01210	Proenkephalin-A	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	XENTR|Xenbase=XB-GENE-482409|UniProtKB=F6UK84	Uncharacterized protein (Fragment)	ISS	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00029	Huntington disease	P00801	Fos protein	TAKRU|Ensembl=ENSTRUG00000010579|UniProtKB=H2TPU7	Uncharacterized protein	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MACMU|Ensembl=ENSMMUG00000007027|UniProtKB=F7F210	Alpha-cardiac actin	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P02749	Leucine biosynthesis	P03001	3-Isopropylmalate dehydrogenase	LEPIN|EnsemblGenome=LA_2152|UniProtKB=P24015	3-isopropylmalate dehydrogenase	ISS			PTHR42979:SF1	3-ISOPROPYLMALATE DEHYDROGENASE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	DICPU|Gene=DICPUDRAFT_47166|UniProtKB=F0ZI20	Beta tubulin	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00005	Angiogenesis	P00223	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01392	TFIIH complex	MONDO|Ensembl=ENSMODG00000015851|UniProtKB=F7F0D8	Uncharacterized protein	ISS			PTHR13152:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00057	Wnt signaling pathway	P01446	Calcineurin	ORNAN|Ensembl=ENSOANG00000010781|UniProtKB=F6X434	Serine/threonine-protein phosphatase	ISS	12015605	PubMed	PTHR11668:SF186	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT GAMMA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ARATH|TAIR=AT2G18170|UniProtKB=Q39027	Mitogen-activated protein kinase 7	IDA			PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P00057	Wnt signaling pathway	P01448	CBP	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04371	5-Hydroxytryptamine biosynthesis	P04400	Aromatic L-amino acid decarboxylase	DROME|FlyBase=FBgn0000422|UniProtKB=P05031	Aromatic-L-amino-acid decarboxylase	ISS	90339966	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	RAT|RGD=2518|UniProtKB=P18901	D(1A) dopamine receptor	ISS	15328036	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P02740	De novo pyrimidine ribonucleotides biosythesis	P02922	Orotate phosphoribosyltransferase	MYCTU|EnsemblGenome=Rv0382c|UniProtKB=P9WHK9	Orotate phosphoribosyltransferase	ISS			PTHR19278:SF9	URIDINE 5'-MONOPHOSPHATE SYNTHASE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00055	Transcription regulation by bZIP transcription factor	P01386	TFIIEbeta	BOVIN|Gene=GTF2E2|UniProtKB=Q2KJF9	General transcription factor IIE subunit 2	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01181	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00012	Cadherin signaling pathway	P00470	F-actin	ARATH|TAIR=AT3G46520|UniProtKB=P53497	Actin-12	IC	14684598	PubMed	PTHR11937:SF276	ACTIN-12
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02740	De novo pyrimidine ribonucleotides biosythesis	P02922	Orotate phosphoribosyltransferase	YEAST|SGD=S000004574|UniProtKB=P13298	Orotate phosphoribosyltransferase 1	ISS			PTHR19278:SF9	URIDINE 5'-MONOPHOSPHATE SYNTHASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g234494|UniProtKB=A7RU31	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00029	Huntington disease	P00807	Actin	BOVIN|Ensembl=ENSBTAG00000005714|UniProtKB=Q3ZC07	Actin, alpha cardiac muscle 1	ISS	3487386	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P02770	Pyridoxal phosphate salvage pathway	P03123	Pyridoxine-5-phosphate oxidase	HUMAN|HGNC=30260|UniProtKB=Q9NVS9	Pyridoxine-5'-phosphate oxidase	ISS	14697241	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	DANRE|ZFIN=ZDB-GENE-040718-134|UniProtKB=Q6DH55	Guanine nucleotide binding protein (G protein), beta polypeptide 3, like	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00005	Angiogenesis	P00207	Crk	RAT|RGD=1308531|UniProtKB=Q5U2U2	Crk-like protein	ISS	8649368	PubMed	PTHR19969:SF9	CRK-LIKE PROTEIN
P04393	Ras Pathway	P04559	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	AQUAE|EnsemblGenome=aq_186|UniProtKB=O66573	Aldehyde dehydrogenase	IC	14724059	PubMed	PTHR42991:SF1	ALDEHYDE DEHYDROGENASE
P05734	Synaptic vesicle trafficking	P05778	SNAP-25	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01451	Galpha	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	IDA	14765990	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF31	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	PANTR|Ensembl=ENSPTRG00000008746|UniProtKB=H2QC84	Myosin, heavy chain 10, non-muscle	ISS	89264452	PubMed	PTHR13140:SF328	MYOSIN-10
P00006	Apoptosis signaling pathway	P00310	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	IDA	14526383	PubMed	PTHR10048:SF14	PI-3 KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00846	JAK	MOUSE|MGI=MGI=96629|UniProtKB=Q62120	Tyrosine-protein kinase JAK2	IDA	22482294	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MOUSE|MGI=MGI=87905|UniProtKB=P68033	Actin, alpha cardiac muscle 1	IDA	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00021	FGF signaling pathway	P00629	PP2A	DICDI|dictyBase=DDB_G0272118|UniProtKB=Q9U9A3	Serine/threonine-protein phosphatase 6 catalytic subunit	NAS			PTHR11668:SF24	SERINE/THREONINE-PROTEIN PHOSPHATASE 6 CATALYTIC SUBUNIT
P00059	p53 pathway	P04609	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04543	MEKK1/4	RAT|RGD=620966|UniProtKB=Q62925	Mitogen-activated protein kinase kinase kinase 1	IDA	12168099	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01322	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	XENTR|Xenbase=XB-GENE-969601|UniProtKB=Q28H40	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CANLF|Gene=GRIN1|UniProtKB=Q5R1P0	Glutamate receptor ionotropic, NMDA 1	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00012	Cadherin signaling pathway	P00475	Frizzled	MACMU|Ensembl=ENSMMUG00000013215|UniProtKB=F6X7X4	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF31	FRIZZLED-7
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00059	p53 pathway	P04609	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01286	TGFbeta	RAT|RGD=2211|UniProtKB=P49001	Bone morphogenetic protein 2	TAS	9759503	PubMed	PTHR11848:SF143	BONE MORPHOGENETIC PROTEIN 2
P00010	B cell activation	P00385	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12960248	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00023	General transcription regulation	P00658	TBP-associated factors	MOUSE|MGI=MGI=1916026|UniProtKB=Q99JX1	Transcription initiation factor TFIID subunit 11	ISS			PTHR13218:SF8	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IPI	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00005	Angiogenesis	P00222	VEGFR-2	PANTR|Ensembl=ENSPTRG00000016069|UniProtKB=H2QPH6	Uncharacterized protein	ISS	11221852	PubMed	PTHR24416:SF45	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2
P00005	Angiogenesis	P00186	FGFR-1	MOUSE|MGI=MGI=95522|UniProtKB=P16092	Fibroblast growth factor receptor 1	ISS	9989949	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P02778	Sulfate assimilation	P03167	Sulfate adenylyltransferase	CAEEL|WormBase=WBGene00004091|UniProtKB=A0A061AE05	3'-Phosphoadenosine 5'-Phosphosulfate Synthetase	ISS			PTHR11055:SF1	PAPS SYNTHETASE, ISOFORM D
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=3784|UniProtKB=P61265	Syntaxin-1B	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P05731	GABA-B receptor II signaling	P05754	Ggamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	RCA	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P02740	De novo pyrimidine ribonucleotides biosythesis	P02922	Orotate phosphoribosyltransferase	DROME|FlyBase=FBgn0003257|UniProtKB=Q01637	Uridine 5'-monophosphate synthase	ISS			PTHR19278:SF9	URIDINE 5'-MONOPHOSPHATE SYNTHASE
P00036	Interleukin signaling pathway	P00973	PKB	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	8170357	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00025	Hedgehog signaling pathway	P00682	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176910	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	RAT|RGD=2746|UniProtKB=P31424	Metabotropic glutamate receptor 5	ISS	8314195	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00049	Parkinson disease	P01242	Casein kinase I	CHICK|Ensembl=ENSGALG00000002719|UniProtKB=E1BVW0	Uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	TAKRU|Ensembl=ENSTRUG00000000811|UniProtKB=H2RP90	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MONDO|Ensembl=ENSMODG00000001775|UniProtKB=F6WJB1	Uncharacterized protein	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02755	Methylmalonyl pathway	P03034	Methylmalonyl-CoA mutase	CANLF|Ensembl=ENSCAFG00000002111|UniProtKB=E2RKY4	Uncharacterized protein	ISS			PTHR42710:SF1	METHYLMALONYL-COA MUTASE, MITOCHONDRIAL
P00025	Hedgehog signaling pathway	P00692	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00005	Angiogenesis	P00223	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00005	Angiogenesis	P00219	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04393	Ras Pathway	P04542	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	ORNAN|Ensembl=ENSOANG00000010227|UniProtKB=F7B5P0	Uncharacterized protein	ISS			PTHR10937:SF10	GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE  ISOMERIZING  2
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	IPI	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01438	PP2A	BRAFL|Gene=BRAFLDRAFT_123893|UniProtKB=C3XQF4	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	BOVIN|Gene=DRD2|UniProtKB=P20288	D(2) dopamine receptor	ISS	2137198	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00047	PDGF signaling pathway	P01152	RasGAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	ISS	2842690	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00029	Huntington disease	P00780	Microtubule	PANTR|Ensembl=ENSPTRG00000017939|UniProtKB=Q7JJU6	Tubulin beta chain	ISS	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00047	PDGF signaling pathway	P01164	PDK1/2	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	ISS	11256888	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04393	Ras Pathway	P04542	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02774	Salvage pyrimidine deoxyribonucleotides	P03146	Deoxyuridine kinase	PANTR|Ensembl=ENSPTRG00000009704|UniProtKB=H2QDZ3	Thymidine kinase	ISS			PTHR11441:SF0	THYMIDINE KINASE, CYTOSOLIC
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=8156|UniProtKB=P35372	Mu-type opioid receptor	IDA	11259498	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	IC	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P06664	Gonadotropin-releasing hormone receptor pathway	P06861	MAP4Ks	MOUSE|MGI=MGI=1925503|UniProtKB=Q8BPM2	Mitogen-activated protein kinase kinase kinase kinase 5	RCA	10702802	PubMed	PTHR24361:SF324	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 5
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	EMENI|EnsemblGenome=CADANIAG00006588|UniProtKB=Q9HFQ2	Serine/threonine-protein phosphatase PP2A catalytic subunit	ISS			PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	IDA	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00045	Notch signaling pathway	P01110	Presenilin	XENTR|Xenbase=XB-GENE-481916|UniProtKB=F6YF14	Presenilin	ISS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00543	ERK1-2	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00941	Integrin alpha	PANTR|Ensembl=ENSPTRG00000012719|UniProtKB=H2R6C3	Integrin, alpha V (Vitronectin receptor, alpha polypeptide, antigen CD51)	ISS	3487386	PubMed	PTHR23220:SF4	INTEGRIN ALPHA-V
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	HUMAN|HGNC=10003|UniProtKB=P49802	Regulator of G-protein signaling 7	IDA	8756726	PubMed	PTHR10845:SF26	REGULATOR OF G-PROTEIN SIGNALING 7
P00048	PI3 kinase pathway	P01181	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IGI	12707323	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00006	Apoptosis signaling pathway	P00269	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	PANTR|Ensembl=ENSPTRG00000004718|UniProtKB=H2Q5I0	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00006	Apoptosis signaling pathway	P00316	Bcl-w	PANTR|Ensembl=ENSPTRG00000006167|UniProtKB=H2Q805	BCL2-like 2	ISS	8761287	PubMed	PTHR11256:SF13	BCL-2-LIKE PROTEIN 2
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MACMU|Ensembl=ENSMMUG00000019112|UniProtKB=F6T8S6	N-methyl D-aspartate receptor subtype 2B	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DICDI|dictyBase=DDB_G0283907|UniProtKB=P34099	cAMP-dependent protein kinase catalytic subunit	IC	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	PANTR|Ensembl=ENSPTRG00000012134|UniProtKB=H2QI93	S-adenosylmethionine synthase	ISS			PTHR11964:SF12	S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00012	Cadherin signaling pathway	P00465	TCF/LEF	XENTR|Xenbase=XB-GENE-485517|UniProtKB=F6WCX0	Uncharacterized protein	ISS	9039917	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MACMU|Ensembl=ENSMMUG00000014262|UniProtKB=F7BYS8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MACMU|Ensembl=ENSMMUG00000001661|UniProtKB=F7GR69	Uncharacterized protein	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00049	Parkinson disease	P01238	14-3-3	CANLF|Ensembl=ENSCAFG00000013549|UniProtKB=E2QVP6	Uncharacterized protein	ISS	22165492	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00010	B cell activation	P00379	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02746	Heme biosynthesis	P02972	Ferrochelatase	PSEAE|EnsemblGenome=PA4655|UniProtKB=Q9HVD7	Ferrochelatase	ISS			PTHR11108:SF1	FERROCHELATASE, MITOCHONDRIAL
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	CHICK|Ensembl=ENSGALG00000015835|UniProtKB=F1NZT2	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00030	Hypoxia response via HIF activation	P00819	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00048	PI3 kinase pathway	P01182	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00034	Integrin signalling pathway	P00916	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	HUMAN|HGNC=9509|UniProtKB=P49810	Presenilin-2	TAS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CAEEL|WormBase=WBGene00003777|UniProtKB=G5EBY3	Non-muscle MYosin	IC			PTHR13140:SF287	NON-MUSCLE MYOSIN
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CHICK|Ensembl=ENSGALG00000004790|UniProtKB=P49337	Protein Wnt-4	TAS	11266476	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MOUSE|MGI=MGI=102705|UniProtKB=P63213	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IDA	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	RAT|RGD=3130|UniProtKB=P09416	Myc proto-oncogene protein	IEP	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P05913	Enkephalin release	P05972	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00965	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00193	SOS-1	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00005	Angiogenesis	P00251	cPLA2	BOVIN|Ensembl=ENSBTAG00000013298|UniProtKB=A4IFJ5	Cytosolic phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	DANRE|ZFIN=ZDB-GENE-990415-28|UniProtKB=Q7ZU33	Ck2a2 protein	IDA	10806215	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00049	Parkinson disease	P01219	SAPK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00053	T cell activation	P01331	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	BRAFL|Gene=BRAFLDRAFT_279431|UniProtKB=C3ZME6	Putative uncharacterized protein	IEP	12356903	PubMed	PTHR11267:SF106	T-RELATED PROTEIN
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	IXOSC|EnsemblGenome=ISCW014549|UniProtKB=B7QGY5	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	DANRE|ZFIN=ZDB-GENE-030616-563|UniProtKB=Q7SXL3	TATA-box-binding protein	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	MOUSE|MGI=MGI=109161|UniProtKB=Q8VEB1	G protein-coupled receptor kinase 5	RCA			PTHR24355:SF27	G PROTEIN-COUPLED RECEPTOR KINASE 5
P00056	VEGF signaling pathway	P01425	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	3755548	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS			PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00036	Interleukin signaling pathway	P00973	PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01414	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00029	Huntington disease	P00790	beta-Tubulin	HUMAN|HGNC=20773|UniProtKB=Q3ZCM7	Tubulin beta-8 chain	TAS	12932731	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01182	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00034	Integrin signalling pathway	P00925	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	BOVIN|Ensembl=ENSBTAG00000004305|UniProtKB=O46471	Regulator of G-protein signaling 16	IDA	8756726	PubMed	PTHR10845:SF187	REGULATOR OF G-PROTEIN SIGNALING 16
P00047	PDGF signaling pathway	P01162	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00025	Hedgehog signaling pathway	P00692	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MOUSE|MGI=MGI=87909|UniProtKB=P62737	Actin, aortic smooth muscle	IC	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00023	General transcription regulation	P00660	RNA Polymerase II	XENTR|Xenbase=XB-GENE-491773|UniProtKB=F7CRN2	Uncharacterized protein	ISS	606023	OMIM	PTHR10917:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3
P00054	Toll receptor signaling pathway	P01355	AP1	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00005	Angiogenesis	P00219	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05730	Endogenous cannabinoid signaling	P05746	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IC	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00046	Oxidative stress response	P01132	c-jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00045	Notch signaling pathway	P01103	Next	HUMAN|HGNC=7882|UniProtKB=Q04721	Neurogenic locus notch homolog protein 2	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	BOVIN|Ensembl=ENSBTAG00000010191|UniProtKB=Q08E52	Serine/threonine-protein kinase PAK 1	ISS	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00018	EGF receptor signaling pathway	P00547	PP2A	ANOGA|EnsemblGenome=AGAP010172|UniProtKB=Q7PD38	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05918	p38 MAPK pathway	P06025	SRF	CANLF|Ensembl=ENSCAFG00000001829|UniProtKB=F1PH12	Uncharacterized protein	ISS	15170389	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P04393	Ras Pathway	P04556	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DANRE|ZFIN=ZDB-GENE-070705-73|UniProtKB=B8A561	Uncharacterized protein	IEP	10938134	PubMed	PTHR13140:SF676	MYOSIN, HEAVY POLYPEPTIDE 2, FAST MUSCLE SPECIFIC
P00049	Parkinson disease	P01211	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00898	FKHR	RAT|RGD=1309196|UniProtKB=D3ZBQ1	Forkhead box O3a (Predicted)	ISS	10102273	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00034	Integrin signalling pathway	P00925	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	PANTR|Ensembl=ENSPTRG00000023608|UniProtKB=H2QZZ2	Uncharacterized protein	ISS	11319238	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00005	Angiogenesis	P00238	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	SCHPO|PomBase=SPAPB1A10.11c|UniProtKB=Q9HDX9	Glutamate--tRNA ligase, mitochondrial	ISS			PTHR43311:SF2	GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED
P00004	Alzheimer disease-presenilin pathway	P00126	Fe65	BOVIN|Ensembl=ENSBTAG00000001450|UniProtKB=F1N3C4	Uncharacterized protein	ISS			PTHR14058:SF10	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 3
P00012	Cadherin signaling pathway	P00475	Frizzled	RAT|RGD=1560525|UniProtKB=Q498S8	Frizzled-8	ISS	8717036	PubMed	PTHR11309:SF90	FRIZZLED-8
P00023	General transcription regulation	P00658	TBP-associated factors	MOUSE|MGI=MGI=109576|UniProtKB=Q6PDZ2	TATA box-binding protein-associated factor RNA polymerase I subunit C	ISS	604905	OMIM	PTHR15319:SF1	TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT C
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04558	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IDA	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	RAT|RGD=2342|UniProtKB=P08482	Muscarinic acetylcholine receptor M1	TAS	12915051	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00029	Huntington disease	P00768	Apaf-1	MACMU|Ensembl=ENSMMUG00000022404|UniProtKB=F6U0K7	Apoptotic protease-activating factor 1	ISS	9267021	PubMed	PTHR22845:SF5	APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
P00012	Cadherin signaling pathway	P00474	Wnt	MACMU|Ensembl=ENSMMUG00000018445|UniProtKB=F7HEW6	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	DROME|FlyBase=FBgn0015024|UniProtKB=P54367	Casein kinase I isoform alpha	IDA	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00053	T cell activation	P01324	rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	7925653	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P02777	Succinate to proprionate conversion	P03163	Methylmalonyl-CoA decarboxylase	STRCO|Gene=CAA19983|UniProtKB=O86517	Putative carboxyl transferase	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	CANLF|Ensembl=ENSCAFG00000029969|UniProtKB=J9P4G6	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF184	REGULATOR OF G-PROTEIN SIGNALING 4
P00021	FGF signaling pathway	P00643	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00318	PKCs	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IDA	3045562	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00025	Hedgehog signaling pathway	P00682	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	15313841	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P05915	Opioid proenkephalin pathway	P05992	met-Enkephalin	BOVIN|Ensembl=ENSBTAG00000004924|UniProtKB=P01211	Proenkephalin-A	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	RCA	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00005	Angiogenesis	P00238	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	YEAST|SGD=S000000825|UniProtKB=P32263	Pyrroline-5-carboxylate reductase	ISS			PTHR11645:SF0	PYRROLINE-5-CARBOXYLATE REDUCTASE
P00018	EGF receptor signaling pathway	P00564	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12960248	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CAEBR|Gene=CBG02401|UniProtKB=A8WUE7	Protein CBR-NMR-1	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IDA	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MONDO|Ensembl=ENSMODG00000012546|UniProtKB=F6PM16	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00012	Cadherin signaling pathway	P00466	EGFR	HUMAN|HGNC=3431|UniProtKB=P21860	Receptor tyrosine-protein kinase erbB-3	ISS	20477399	gi	PTHR24416:SF88	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IDA	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00049	Parkinson disease	P01236	Casein kinase II	PANTR|Ensembl=ENSPTRG00000008175|UniProtKB=H2RA57	Uncharacterized protein	ISS	10806215	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04496	Mdm2	MACMU|Ensembl=ENSMMUG00000011236|UniProtKB=F6WXF0	Uncharacterized protein	ISS			PTHR13844:SF20	PROTEIN MDM4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00012	Cadherin signaling pathway	P00470	F-actin	SCHMA|EnsemblGenome=Smp_046600|UniProtKB=G4VLW2	Putative actin-1	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	DANRE|ZFIN=ZDB-GENE-040120-7|UniProtKB=Q7ZWH4	Actin-related protein 2/3 complex subunit 5	ISS	12932731	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P02785	Valine biosynthesis	P03216	Acetolactate synthase	THEMA|EnsemblGenome=TM_0548|UniProtKB=Q9WZ18	Acetolactate synthase	ISS			PTHR18968:SF116	ACETOLACTATE SYNTHASE ISOZYME 3 LARGE SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00024	Glycolysis	P00680	Phosphoglyceromutase	ECOLI|EcoGene=EG11699|UniProtKB=P62707	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase	ISS	21534947	PubMed	PTHR11931:SF20	2,3-BISPHOSPHOGLYCERATE-DEPENDENT PHOSPHOGLYCERATE MUTASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	PANTR|Ensembl=ENSPTRG00000000843|UniProtKB=H2QZN8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00053	T cell activation	P01332	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00632	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IGI	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DANRE|ZFIN=ZDB-GENE-041001-104|UniProtKB=Q5TZD4	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00020	FAS signaling pathway	P00615	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00034	Integrin signalling pathway	P00924	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	IPI	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00040	Metabotropic glutamate receptor group II pathway	G01540	BDNF	MOUSE|MGI=MGI=88145|UniProtKB=P21237	Brain-derived neurotrophic factor	ISS	11408619	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00057	Wnt signaling pathway	P01435	SWI/SNF	YEAST|SGD=S000001934|UniProtKB=P43610	Uncharacterized ATP-dependent helicase IRC5	ISS	11532957	PubMed	PTHR10799:SF812	LYMPHOID-SPECIFIC HELICASE
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	PANTR|Ensembl=ENSPTRG00000019277|UniProtKB=H2QUQ1	Uncharacterized protein	ISS	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00053	T cell activation	P01330	IKK	HUMAN|HGNC=1974|UniProtKB=O15111	Inhibitor of nuclear factor kappa-B kinase subunit alpha	IGI	14499113	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00054	Toll receptor signaling pathway	P01369	MKK1	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00775	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	HUMAN|HGNC=4383|UniProtKB=P30679	Guanine nucleotide-binding protein subunit alpha-15	IC	8838318	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P00047	PDGF signaling pathway	P01153	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	DANRE|ZFIN=ZDB-GENE-030407-2|UniProtKB=F8W5D0	Uncharacterized protein (Fragment)	ISS			PTHR11681:SF13	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	TAKRU|Ensembl=ENSTRUG00000016101|UniProtKB=H2UW32	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00052	TGF-beta signaling pathway	P01286	TGFbeta	BOVIN|Ensembl=ENSBTAG00000015362|UniProtKB=F1MLT0	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF135	BONE MORPHOGENETIC PROTEIN 7
P00010	B cell activation	P00370	NFkappaB	RAT|RGD=1307189|UniProtKB=Q5U2Z4	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	ISS	20151924	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01082	AC	DICDI|dictyBase=DDB_G0276269|UniProtKB=Q551V8	Guanylyl cyclase	IC	9874775	PubMed	PTHR43642:SF2	GUANYLYL CYCLASE
P02723	Adenine and hypoxanthine salvage pathway	P02809	Xanthine dehydrogenase	CHICK|Gene=XDH|UniProtKB=P47990	Xanthine dehydrogenase/oxidase	ISS	7852355	PubMed	PTHR11908:SF80	XANTHINE DEHYDROGENASE/OXIDASE
P02752	Mannose metabolism	P03017	Mannose 6-P isomerase	LEIMA|EnsemblGenome=LmjF.32.1580|UniProtKB=Q4Q5C3	Mannose-6-phosphate isomerase	ISS	11084042	PubMed	PTHR10309:SF0	MANNOSE-6-PHOSPHATE ISOMERASE
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00049	Parkinson disease	P01242	Casein kinase I	MACMU|Ensembl=ENSMMUG00000001758|UniProtKB=F6TN15	Uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF84	CASEIN KINASE I ISOFORM ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00906	Rap1	ENTHI|EnsemblGenome=EHI_058090|UniProtKB=C4M8B0	Ras family GTPase	IC	8576107	PubMed	PTHR24070:SF263	RAS-LIKE PROTEIN 3
P00036	Interleukin signaling pathway	P00996	STAT	BOVIN|Gene=STAT5A|UniProtKB=Q95115	Signal transducer and activator of transcription 5A	IC	8584036	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	BOVIN|Ensembl=ENSBTAG00000025337|UniProtKB=F1MZX6	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF504	MYOSIN-13
P00049	Parkinson disease	P01219	SAPK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000000985|UniProtKB=F6VRS9	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00021	FGF signaling pathway	P00632	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04651	Ras	DANRE|ZFIN=ZDB-GENE-040808-67|UniProtKB=Q6AZA4	K-ras	ISS	20362513	PubMed	PTHR24070:SF186	GTPASE KRAS
P04393	Ras Pathway	P04567	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IDA	14526383	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00014	Cholesterol biosynthesis	P00494	Squalene monooxygenas	ARATH|TAIR=AT1G58440|UniProtKB=Q9SM02	Squalene epoxidase 1	ISS			PTHR10835:SF0	SQUALENE MONOOXYGENASE
P00057	Wnt signaling pathway	P01472	Histone deacetylase	MOUSE|MGI=MGI=1343091|UniProtKB=O88895	Histone deacetylase 3	IDA	10485845	PubMed	PTHR10625:SF132	HISTONE DEACETYLASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	TAKRU|Ensembl=ENSTRUG00000007253|UniProtKB=H2SZQ1	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P02751	Lysine biosynthesis	P03006	Dihydrodipicolinate  reductase	ECOLI|EcoGene=EG10206|UniProtKB=P04036	4-hydroxy-tetrahydrodipicolinate reductase	ISS			PTHR20836:SF0	DIHYDRODIPICOLINATE REDUCTASE-LIKE PROTEIN CRR1, CHLOROPLASTIC
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	MONDO|Ensembl=ENSMODG00000012141|UniProtKB=F7DI08	Aldehyde dehydrogenase	ISS			PTHR11699:SF209	ALDEHYDE DEHYDROGENASE FAMILY 1 MEMBER A3
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	MONDO|Ensembl=ENSMODG00000014177|UniProtKB=F6U7A6	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	ORYSJ|EnsemblGenome=OS01G0267900|UniProtKB=Q0JNS6	Calmodulin-1	ISS			PTHR23050:SF245	AT16150P-RELATED
P04397	p53 pathway by glucose deprivation	P04644	TSC2	HUMAN|HGNC=12363|UniProtKB=P49815	Tuberin	ISS	15249583	PubMed	PTHR10063:SF0	TUBERIN
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00009	Axon guidance mediated by netrin	P00363	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	1171954	gi	PTHR10048:SF14	PI-3 KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00021	FGF signaling pathway	P00632	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IGI	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	HUMAN|HGNC=1951|UniProtKB=P08172	Muscarinic acetylcholine receptor M2	ISS	10069496	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT4G01370|UniProtKB=Q39024	Mitogen-activated protein kinase 4	IDA	10514528	PubMed	PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Ensembl=ENSBTAG00000037726|UniProtKB=P10895	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	7822322	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00054	Toll receptor signaling pathway	P01355	AP1	XENTR|Xenbase=XB-GENE-482228|UniProtKB=F6RYL1	Uncharacterized protein	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00025	Hedgehog signaling pathway	P00682	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MONDO|Ensembl=ENSMODG00000014736|UniProtKB=F6ZC55	Phosphoinositide phospholipase C	ISS			PTHR10336:SF84	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000012036|UniProtKB=F7ALP1	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DANRE|ZFIN=ZDB-GENE-050417-267|UniProtKB=F1QUN8	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF263	ACTIN
P02777	Succinate to proprionate conversion	P03163	Methylmalonyl-CoA decarboxylase	BACSU|EnsemblGenome=BSU18210|UniProtKB=O31825	Uncharacterized carboxylase YngE	ISS			PTHR22855:SF36	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	NEUCR|EnsemblGenome=EFNCRG00000000159|UniProtKB=F5HH30	Guanine nucleotide-binding protein beta subunit	IC	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	HUMAN|HGNC=1952|UniProtKB=P20309	Muscarinic acetylcholine receptor M3	TAS	11166329	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00049	Parkinson disease	P01211	ERK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	IDA	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04393	Ras Pathway	P04570	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	IDA	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00539	14-3-3	XENTR|Xenbase=XB-GENE-951350|UniProtKB=Q0V9W8	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	ISS	9507245	gi	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00052	TGF-beta signaling pathway	P01275	P38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	HUMAN|HGNC=7577|UniProtKB=P12883	Myosin-7	ISS	89264452	PubMed	PTHR13140:SF344	MYOSIN-7
P00019	Endothelin signaling pathway	P00583	cPLA2	BOVIN|Ensembl=ENSBTAG00000013298|UniProtKB=A4IFJ5	Cytosolic phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00237	FRP	HUMAN|HGNC=4041|UniProtKB=Q9NPG1	Frizzled-3	IC	11212302	PubMed	PTHR11309:SF22	FRIZZLED-3
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00006	Apoptosis signaling pathway	P00274	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04407	K+ channel	HUMAN|HGNC=6283|UniProtKB=Q9NPC2	Potassium channel subfamily K member 9	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04558	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00005	Angiogenesis	P00256	PLC-gamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05915	Opioid proenkephalin pathway	P05987	peptide F	MOUSE|MGI=MGI=104629|UniProtKB=P22005	Proenkephalin-A	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00034	Integrin signalling pathway	P00925	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CHICK|Ensembl=ENSGALG00000011248|UniProtKB=F1P354	Phosphoinositide phospholipase C	ISS			PTHR10336:SF84	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MONDO|Ensembl=ENSMODG00000006559|UniProtKB=F7BUU3	Adenylosuccinate synthetase isozyme 2	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=102705|UniProtKB=P63213	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_115566|UniProtKB=C3XYC8	Putative uncharacterized protein	IDA	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DANRE|ZFIN=ZDB-GENE-000329-1|UniProtKB=Q7ZVI7	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P06959	CCKR signaling map	P07227	KLF4	HUMAN|HGNC=6348|UniProtKB=O43474	Krueppel-like factor 4	RCA	9341140	PubMed	PTHR44778:SF1	KRUEPPEL-LIKE FACTOR 4
P00005	Angiogenesis	P00236	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	8787761	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TAKRU|Ensembl=ENSTRUG00000004787|UniProtKB=P53480	Actin, alpha cardiac	ISS	10974003	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	HUMAN|HGNC=4586|UniProtKB=Q13224	Glutamate receptor ionotropic, NMDA 2B	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IC	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00048	PI3 kinase pathway	P01192	p110	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06587	Nicotine pharmacodynamics pathway	P06614	TH	RAT|RGD=3853|UniProtKB=P04177	Tyrosine 3-monooxygenase	RCA	12814656	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00021	FGF signaling pathway	P00644	p38	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	IGI	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05912	Dopamine receptor mediated signaling pathway	P05949	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	7689150	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P02776	Serine glycine biosynthesis	P03157	Phosphoserine aminotransferase	BACSU|EnsemblGenome=BSU10020|UniProtKB=P80862	Phosphoserine aminotransferase	ISS	9384377	PubMed	PTHR43247:SF2	PHOSPHOSERINE AMINOTRANSFERASE
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	CHICK|Ensembl=ENSGALG00000012894|UniProtKB=P30372	Muscarinic acetylcholine receptor M2	TAS	8100450	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000002647|UniProtKB=F7DIB7	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MOUSE|MGI=MGI=1336171|UniProtKB=Q9DAS9	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IDA	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00054	Toll receptor signaling pathway	P01368	MKK2	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00012	Cadherin signaling pathway	P00470	F-actin	HUMAN|HGNC=144|UniProtKB=P63261	Actin, cytoplasmic 2	IC	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00049	Parkinson disease	P01242	Casein kinase I	SCHPO|PomBase=SPBC1347.06c|UniProtKB=P40233	Casein kinase I homolog 1	IDA	11437445	PubMed	PTHR11909:SF155	GILGAMESH, ISOFORM L
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	PANTR|Ensembl=ENSPTRG00000006216|UniProtKB=H2Q832	Adenylate cyclase 4	ISS	1946437	PubMed	PTHR11920:SF286	ADENYLATE CYCLASE TYPE 4
P00036	Interleukin signaling pathway	P00983	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04623	CBP	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00011	Blood coagulation	P00408	Plasminogen	PANTR|Ensembl=ENSPTRG00000018774|UniProtKB=H2QU06	Plasminogen	ISS	2318848	PubMed	PTHR24261:SF6	PLASMINOGEN
P04393	Ras Pathway	P04564	MAPKAP	MACMU|Ensembl=ENSMMUG00000023567|UniProtKB=F7HHY8	Uncharacterized protein	ISS	10779545	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00048	PI3 kinase pathway	P01199	Galpha	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	IC	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	IC	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04398	p53 pathway feedback loops 2	G04714	PTEN	ARATH|TAIR=AT5G39400|UniProtKB=Q9FLZ5	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN1	ISS			PTHR12305:SF80	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND PROTEIN-TYROSINE-PHOSPHATASE PTEN1
P00017	DNA replication	P00534	PCNA	SULSO|EnsemblGenome=SSO1047|UniProtKB=Q97Z84	DNA polymerase sliding clamp 2	ISS	21332296	PubMed	PTHR11352:SF0	PROLIFERATING CELL NUCLEAR ANTIGEN
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	ANOGA|EnsemblGenome=AGAP011761|UniProtKB=Q7PZ71	AGAP011761-PA	ISS			PTHR23431:SF3	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5
P00036	Interleukin signaling pathway	P00981	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	TAS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00046	Oxidative stress response	P01122	TRX	PANTR|Ensembl=ENSPTRG00000021245|UniProtKB=H2QXP0	Thioredoxin	ISS	12115731	PubMed	PTHR10438:SF18	THIOREDOXIN
P04393	Ras Pathway	P04557	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IDA	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00049	Parkinson disease	P01230	Src kinase	BOVIN|Ensembl=ENSBTAG00000011851|UniProtKB=A0JNB0	Tyrosine-protein kinase Fyn	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00010	B cell activation	P00384	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05913	Enkephalin release	P05976	Enkephalin	HUMAN|HGNC=8831|UniProtKB=P01210	Proenkephalin-A	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00037	Ionotropic glutamate receptor pathway	P01023	CaMKII	CHICK|Gene_ORFName=RCJMB04_10k21|UniProtKB=Q5ZKI0	Calcium/calmodulin-dependent protein kinase type II delta chain	ISS	12888804	PubMed	PTHR43940:SF4	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT DELTA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00643	Raf-1	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS			PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00059	p53 pathway	P04633	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00541	Spry	CANLF|Ensembl=ENSCAFG00000005260|UniProtKB=E2RGU9	Uncharacterized protein	ISS	12225946	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04398	p53 pathway feedback loops 2	P04657	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00327	FADD	MOUSE|MGI=MGI=109324|UniProtKB=Q61160	FAS-associated death domain protein	IDA	8565075	PubMed	PTHR15077:SF8	FAS-ASSOCIATED DEATH DOMAIN PROTEIN
P00029	Huntington disease	P00807	Actin	RAT|RGD=2027|UniProtKB=P63269	Actin, gamma-enteric smooth muscle	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	DANRE|ZFIN=ZDB-GENE-030407-1|UniProtKB=F1QC27	Uncharacterized protein	ISS			PTHR11681:SF14	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04668	p53	MACMU|Ensembl=ENSMMUG00000008639|UniProtKB=P56424	Cellular tumor antigen p53	TAS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P06664	Gonadotropin-releasing hormone receptor pathway	P06807	gnai	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	RCA	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PANTR|Ensembl=ENSPTRG00000002086|UniProtKB=H2Q1A9	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00053	T cell activation	P01319	PAK	MACMU|Ensembl=ENSMMUG00000001387|UniProtKB=F7D0B4	Uncharacterized protein	ISS	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CANAL|CGD=CAL0000190895|UniProtKB=Q9HEW1	cAMP-dependent protein kinase regulatory subunit	ISS	176892	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00590	IP3 R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P05913	Enkephalin release	P05974	G-Protein (i)	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00056	VEGF signaling pathway	P01407	Erk	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g169611|UniProtKB=A7SEB1	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00037	Ionotropic glutamate receptor pathway	P01026	KA	RAT|RGD=2732|UniProtKB=P22756	Glutamate receptor ionotropic, kainate 1	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P02738	De novo purine biosynthesis	P02900	AICAR transformylase	HUMAN|HGNC=794|UniProtKB=P31939	Bifunctional purine biosynthesis protein PURH	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00009	Axon guidance mediated by netrin	P00366	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	21244534	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00049	Parkinson disease	P01208	Hsp70	PANTR|Ensembl=ENSPTRG00000029753|UniProtKB=H2RF71	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF223	HEAT SHOCK 70 KDA PROTEIN 1A-RELATED
P00038	JAK/STAT signaling pathway	P01027	STAT	MONDO|Ensembl=ENSMODG00000014816|UniProtKB=F7CHH2	Signal transducer and activator of transcription	ISS	10835485	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	RCA	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06852	nPKCs	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	RCA	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00021	FGF signaling pathway	P00629	PP2A	XENTR|Xenbase=XB-GENE-950078|UniProtKB=F7C2I9	Uncharacterized protein (Fragment)	ISS			PTHR10648:SF9	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 65 KDA REGULATORY SUBUNIT A BETA ISOFORM
P00059	p53 pathway	G01572	NOXA	PANTR|Ensembl=ENSPTRG00000002582|UniProtKB=H2Q210	Apoptosis-inducing factor, mitochondrion-associated, 2	ISS			PTHR43735:SF9	APOPTOSIS-INDUCING FACTOR 2
P02723	Adenine and hypoxanthine salvage pathway	P02810	Adenine phosphoribosyl transferase	BACSU|EnsemblGenome=BSU27610|UniProtKB=O34443	Adenine phosphoribosyltransferase	ISS			PTHR11776:SF0	ADENINE PHOSPHORIBOSYLTRANSFERASE-RELATED
P00047	PDGF signaling pathway	P01160	IP3 receptor	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	87226391	PubMed	PTHR24070:SF385	GTPASE HRAS
P00056	VEGF signaling pathway	P01411	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P04398	p53 pathway feedback loops 2	G04711	SIAH-1	RAT|RGD=620449|UniProtKB=Q920M9	E3 ubiquitin-protein ligase SIAH1	ISS	11389839	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CHICK|Ensembl=ENSGALG00000008898|UniProtKB=F1P2J9	Uncharacterized protein	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P05731	GABA-B receptor II signaling	P05760	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00012	Cadherin signaling pathway	P00462	Casein kinase II	CANLF|Ensembl=ENSCAFG00000006946|UniProtKB=E2RHZ1	Uncharacterized protein	ISS	10806215	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P02738	De novo purine biosynthesis	P02898	Phosphoribosylformylglycinamide  synthase	MACMU|Ensembl=ENSMMUG00000013536|UniProtKB=F7FV75	Uncharacterized protein	ISS			PTHR10099:SF1	PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE
P00018	EGF receptor signaling pathway	P00547	PP2A	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05916	Opioid prodynorphin pathway	P06002	G-protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	1482697	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00046	Oxidative stress response	P01129	JNK1/2	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00004	Alzheimer disease-presenilin pathway	P00139	E-cadherin transmembrane fragment	MOUSE|MGI=MGI=88356|UniProtKB=P10287	Cadherin-3	IDA	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P00059	p53 pathway	P04616	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	12855688	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IDA	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	ISS	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00047	PDGF signaling pathway	P01159	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	CAEEL|WormBase=WBGene00004958|UniProtKB=Q01608	Presenilin spe-4	TAS	12834808	PubMed	PTHR10202:SF17	PRESENILIN SPE-4
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MOUSE|MGI=MGI=1933206|UniProtKB=A2AIR5	Protein Grin3a	ISS	11554554	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P02746	Heme biosynthesis	P02980	Coproporphyrinogen Oxidase (oxygen dependent)	DROME|FlyBase=FBgn0021944|UniProtKB=Q9V3D2	Oxygen-dependent coproporphyrinogen-III oxidase	ISS			PTHR10755:SF0	OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00005	Angiogenesis	P00238	Ras	DICPU|Gene=DICPUDRAFT_47179|UniProtKB=F0ZI47	Putative uncharacterized protein rasB	ISS			PTHR24070:SF206	RAS-LIKE PROTEIN RASB
P00005	Angiogenesis	P00246	Ang-2	DANRE|ZFIN=ZDB-GENE-010817-2|UniProtKB=Q1LWR7	Angiopoietin 2	ISS			PTHR19143:SF243	ANGIOPOIETIN 2
P00046	Oxidative stress response	P01135	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	3755548	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00023	General transcription regulation	P00658	TBP-associated factors	YEAST|SGD=S000000638|UniProtKB=P23255	Transcription initiation factor TFIID subunit 2	ISS			PTHR15137:SF9	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00005	Angiogenesis	P00254	GTPase	YARLI|EnsemblGenome=YALI0_D01045g|UniProtKB=Q6CAP4	YALI0D01045p	ISS			PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	RAT|RGD=1308692|UniProtKB=A0A0G2JTY4	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 (Predicted), isoform CRA_b	ISS	9462517	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CAEBR|Gene=CBG03422|UniProtKB=A8WV10	Protein CBR-CWN-2	ISS	8717036	PubMed	PTHR12027:SF77	PROTEIN WNT-5
P00003	Alzheimer disease-amyloid secretase pathway	P00107	kinesin	MACMU|Ensembl=ENSMMUG00000021891|UniProtKB=F6TC28	Uncharacterized protein	ISS	11740561	PubMed	PTHR19959:SF125	KINESIN LIGHT CHAIN 3
P00047	PDGF signaling pathway	P01168	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	129387	gi	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	1170702	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06852	nPKCs	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	RCA	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000000985|UniProtKB=F6VRS9	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BRAFL|Gene=BRAFLDRAFT_113720|UniProtKB=C3YYJ8	Protein Wnt	TAS	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MONDO|Ensembl=ENSMODG00000000771|UniProtKB=F6SSS3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00047	PDGF signaling pathway	P01168	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	DROME|FlyBase=FBgn0001991|UniProtKB=Q24270	Voltage-dependent calcium channel type D subunit alpha-1	ISS	9199552	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00047	PDGF signaling pathway	P01165	SRF	DICDI|dictyBase=DDB_G0281387|UniProtKB=Q54TY7	Serum response factor homolog A	ISS			PTHR11945:SF221	SERUM RESPONSE FACTOR
P00029	Huntington disease	P00810	GAPDH	PLAF7|EnsemblGenome=PF14_0598|UniProtKB=Q8IKK7	Glyceraldehyde-3-phosphate dehydrogenase	IPI			PTHR10836:SF76	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE A
P00029	Huntington disease	P00777	CBP	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	IDA	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04398	p53 pathway feedback loops 2	G04709	MDM-2	PANTR|Ensembl=ENSPTRG00000005203|UniProtKB=H2R792	Mdm2 p53 binding protein homolog	ISS	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P04393	Ras Pathway	P04560	AP1	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	ISS	http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00047	PDGF signaling pathway	P01160	IP3 receptor	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00047	PDGF signaling pathway	P01153	GSK3	CANLF|Ensembl=ENSCAFG00000004882|UniProtKB=F1PAE3	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01275	P38	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	TAS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00034	Integrin signalling pathway	P00909	ASAP1	HUMAN|HGNC=2720|UniProtKB=Q9ULH1	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1	RCA			PTHR23180:SF192	ARF-GAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	RAT|RGD=620241|UniProtKB=Q9QXN1	Lymphoid enhancer-binding factor 1	TAS	9039917	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Ensembl=ENSBTAG00000037726|UniProtKB=P10895	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	15611108	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P02738	De novo purine biosynthesis	P02901	Adenosuccinate lyase	ECOLI|EcoGene=EG11314|UniProtKB=P0AB89	Adenylosuccinate lyase	ISS			PTHR43411:SF3	ADENYLOSUCCINATE LYASE
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	TAKRU|Ensembl=ENSTRUG00000008289|UniProtKB=H2T7U8	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF129	CDC42L PROTEIN
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	HUMAN|HGNC=7882|UniProtKB=Q04721	Neurogenic locus notch homolog protein 2	IDA	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	YEAST|SGD=S000000872|UniProtKB=P21524	Ribonucleoside-diphosphate reductase large chain 1	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-040426-2427|UniProtKB=F1Q6C0	Uncharacterized protein (Fragment)	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12701063	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DROME|FlyBase=FBgn0010333|UniProtKB=P40792	Ras-related protein Rac1	ISS	12932731	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00046	Oxidative stress response	P01138	MKK4	MOUSE|MGI=MGI=1346869|UniProtKB=P47809	Dual specificity mitogen-activated protein kinase kinase 4	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	MACMU|Ensembl=ENSMMUG00000006659|UniProtKB=F7H3Z0	Aldehyde dehydrogenase family 1 member A3	ISS			PTHR11699:SF209	ALDEHYDE DEHYDROGENASE FAMILY 1 MEMBER A3
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05730	Endogenous cannabinoid signaling	P05746	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00012	Cadherin signaling pathway	P00474	Wnt	CANLF|Ensembl=ENSCAFG00000032632|UniProtKB=J9P2Q5	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00012	Cadherin signaling pathway	P00474	Wnt	MACMU|Ensembl=ENSMMUG00000015709|UniProtKB=F6SLX4	Protein Wnt	ISS	14644163	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000005620|UniProtKB=F6WDU9	Protocadherin-9	ISS	8120095	PubMed	PTHR43912:SF5	PROTOCADHERIN-9
P00005	Angiogenesis	P00193	SOS-1	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IDA	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00019	Endothelin signaling pathway	P00572	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05915	Opioid proenkephalin pathway	P05988	peptide E	BOVIN|Ensembl=ENSBTAG00000004924|UniProtKB=P01211	Proenkephalin-A	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01142	p90RSK	PANTR|Ensembl=ENSPTRG00000022064|UniProtKB=H2QYE0	Uncharacterized protein	ISS	6755374	gi	PTHR24351:SF98	RIBOSOMAL PROTEIN S6 KINASE ALPHA-6
P00053	T cell activation	P01312	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00015	Circadian clock system	G01501	cry	PANTR|Ensembl=ENSPTRG00000003537|UniProtKB=H2Q3H0	Uncharacterized protein	ISS	14507900	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	CAEEL|WormBase=WBGene00002245|UniProtKB=V6CLJ5	Lin-12 And Glp-1 phenotype	NAS	8625826	PubMed	PTHR10665:SF0	SUPPRESSOR OF HAIRLESS PROTEIN
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00049	Parkinson disease	P01242	Casein kinase I	CAEEL|WormBase=WBGene00013709|UniProtKB=Q8WQ99	Casein kinase I gamma	IDA	10617630	PubMed	PTHR11909:SF155	GILGAMESH, ISOFORM L
P00019	Endothelin signaling pathway	P00586	Gq	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00007	Axon guidance mediated by semaphorins	P00341	Rho	XENTR|Xenbase=XB-GENE-489222|UniProtKB=Q28GJ8	Ras homolog gene family, member A	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	IDA	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00019	Endothelin signaling pathway	P00590	IP3 R	CAEEL|WormBase=WBGene00002173|UniProtKB=Q9Y0A1	Inositol 1,4,5-trisphosphate receptor itr-1	ISS	1849282	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00060	Ubiquitin proteasome pathway	P01490	E3	HUMAN|HGNC=16804|UniProtKB=O00308	NEDD4-like E3 ubiquitin-protein ligase WWP2	ISS			PTHR11254:SF396	NEDD4-LIKE E3 UBIQUITIN-PROTEIN LIGASE WWP2
P00022	General transcription by RNA polymerase I	P00649	TAF-IC	RAT|RGD=1308423|UniProtKB=D3ZY89	Protein Taf8	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00052	TGF-beta signaling pathway	P01284	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	IDA	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	MONDO|Ensembl=ENSMODG00000028212|UniProtKB=F7BYN4	Signal transducer and activator of transcription	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00006	Apoptosis signaling pathway	P00269	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00034	Integrin signalling pathway	P00951	Jnk	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00053	T cell activation	P01315	Calcineurin	MONDO|Ensembl=ENSMODG00000020679|UniProtKB=F7DKU1	Serine/threonine-protein phosphatase	ISS	12091710	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	MACMU|Ensembl=ENSMMUG00000017921|UniProtKB=F7EDG8	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF335	CALMODULIN, STRIATED MUSCLE
P00021	FGF signaling pathway	P00648	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IGI	3045562	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02751	Lysine biosynthesis	P03008	Dihydrodipicolinate synthase	PYRAE|EnsemblGenome=PAE2915|UniProtKB=Q8ZU75	Uncharacterized DapA-like lyase PAE2915	ISS			PTHR12128:SF15	4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CHICK|Gene=CHRM4|UniProtKB=P17200	Muscarinic acetylcholine receptor M4	IDA	91373358	PubMed	PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	DROME|FlyBase=FBgn0019947|UniProtKB=O02194	Presenilin homolog	IDA	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IDA	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=103077|UniProtKB=Q64704	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	MACMU|Ensembl=ENSMMUG00000021423|UniProtKB=F7EEZ1	Phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00008	Axon guidance mediated by Slit/Robo	P00342	Slit	MOUSE|MGI=MGI=1315202|UniProtKB=Q9WVB4	Slit homolog 3 protein	ISS			PTHR24373:SF15	SLIT HOMOLOG 3 PROTEIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHICK|Ensembl=ENSGALG00000028749|UniProtKB=Q5ZMQ2	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00036	Interleukin signaling pathway	P00990	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	STRPU|EnsemblGenome=SPU_018419|UniProtKB=W4YRI6	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P02744	Fructose galactose metabolism	P02960	Galactokinase	BOVIN|Ensembl=ENSBTAG00000004011|UniProtKB=F1MFK7	Uncharacterized protein	ISS			PTHR10457:SF7	N-ACETYLGALACTOSAMINE KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00006	Apoptosis signaling pathway	P00269	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05957	K+ channel	BOVIN|Ensembl=ENSBTAG00000018193|UniProtKB=E1BHX8	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00053	T cell activation	P01332	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01021	Vglut	ORNAN|Ensembl=ENSOANG00000013126|UniProtKB=F6T3N3	Uncharacterized protein	ISS	12815758	PubMed	PTHR11662:SF201	VESICULAR GLUTAMATE TRANSPORTER 2
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00003	Alzheimer disease-amyloid secretase pathway	P00101	BACE-1	BOVIN|Ensembl=ENSBTAG00000019365|UniProtKB=Q2HJ40	Beta-secretase 1	ISS	10531052	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00833	RGS	MACMU|Ensembl=ENSMMUG00000001672|UniProtKB=F7G3M7	Uncharacterized protein	ISS	12193720	PubMed	PTHR10845:SF32	REGULATOR OF G-PROTEIN SIGNALING 13
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04397	p53 pathway by glucose deprivation	P04637	4E-BP1	MOUSE|MGI=MGI=103267|UniProtKB=Q60876	Eukaryotic translation initiation factor 4E-binding protein 1	IDA	15494402	PubMed	PTHR12669:SF14	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MACMU|Ensembl=ENSMMUG00000014762|UniProtKB=F7G0R4	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF344	MYOSIN-7
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	MOUSE|MGI=MGI=109284|UniProtKB=Q61144	Presenilin-2	TAS	12885769	PubMed	PTHR10202:SF13	PRESENILIN-2
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P06959	CCKR signaling map	P07156	JAK2	HUMAN|HGNC=6192|UniProtKB=O60674	Tyrosine-protein kinase JAK2	RCA	15530849	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00056	VEGF signaling pathway	P01417	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00022	General transcription by RNA polymerase I	P00657	TBP	HUMAN|HGNC=19841|UniProtKB=Q6SJ96	TATA box-binding protein-like protein 2	ISS	600075	OMIM	PTHR10126:SF34	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 2
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	ANOGA|EnsemblGenome=AGAP001506|UniProtKB=Q7PXP3	AGAP001506-PA	IC			PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	PANTR|Ensembl=ENSPTRG00000016800|UniProtKB=H2QQS3	Solute carrier family 1 (Glial high affinity glutamate transporter), member 3	ISS	94365697	PubMed	PTHR11958:SF24	EXCITATORY AMINO ACID TRANSPORTER 1
P00049	Parkinson disease	P01238	14-3-3	BOVIN|Gene=YWHAG|UniProtKB=P68252	14-3-3 protein gamma	ISS	99360936	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	IC	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04397	p53 pathway by glucose deprivation	P04641	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00200	Dsh	HUMAN|HGNC=3084|UniProtKB=O14640	Segment polarity protein dishevelled homolog DVL-1	IDA	11212302	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	CANLF|Ensembl=ENSCAFG00000005204|UniProtKB=B6V8E6	Catenin beta-1	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_115291|UniProtKB=C3ZMR2	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF359	SUBFAMILY NOT NAMED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01080	AChE	CANLF|Ensembl=ENSCAFG00000014054|UniProtKB=E2RP98	Carboxylic ester hydrolase	ISS	87080761	PubMed	PTHR11559:SF356	ACETYLCHOLINESTERASE
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00030	Hypoxia response via HIF activation	P00819	AKT	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	TAS	12655147	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00020	FAS signaling pathway	P00620	CytochromeC	MACMU|Ensembl=ENSMMUG00000007149|UniProtKB=F7DMP6	Uncharacterized protein	ISS	9027315	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P05730	Endogenous cannabinoid signaling	P05748	mGluR	MOUSE|MGI=MGI=1351342|UniProtKB=Q3UVX5	Metabotropic glutamate receptor 5	ISS	8314195	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	PANTR|Ensembl=ENSPTRG00000010806|UniProtKB=H2QG00	Low density lipoprotein receptor-related protein 3	ISS	11907044	PubMed	PTHR44062:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 3
P04393	Ras Pathway	P04541	p90RSK	MOUSE|MGI=MGI=1342290|UniProtKB=Q9WUT3	Ribosomal protein S6 kinase alpha-2	IDA	1922062	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00048	PI3 kinase pathway	P01192	p110	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00009	Axon guidance mediated by netrin	P00363	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00907	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00047	PDGF signaling pathway	P01147	Nck	MOUSE|MGI=MGI=1306821|UniProtKB=O55033	Cytoplasmic protein NCK2	ISS	12874226	PubMed	PTHR44108:SF1	CYTOPLASMIC PROTEIN NCK2
P04393	Ras Pathway	P04572	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00045	Notch signaling pathway	P01104	Serrate	HUMAN|HGNC=6188|UniProtKB=P78504	Protein jagged-1	IGI	8955070	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00054	Toll receptor signaling pathway	P01352	p38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	XENTR|Xenbase=XB-GENE-479707|UniProtKB=F6QAW3	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF126	FRIZZLED-5
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	IC	1650351	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00054	Toll receptor signaling pathway	P01351	TLR2,4,7	CHICK|Gene=TLR2-2|UniProtKB=Q9DGB6	Toll-like receptor 2 type-2	ISS			PTHR24365:SF17	TOLL-LIKE RECEPTOR 2
P05912	Dopamine receptor mediated signaling pathway	P05957	K+ channel	RAT|RGD=61997|UniProtKB=O54912	Potassium channel subfamily K member 3	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	RAT|RGD=621060|UniProtKB=O88777	Presenilin-2	IDA	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P02744	Fructose galactose metabolism	P02963	Ketohexokinase	HUMAN|HGNC=6315|UniProtKB=P50053	Ketohexokinase	TAS	9799106	PubMed	PTHR43085:SF1	KETOHEXOKINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00010	B cell activation	P00369	MEKK	PANTR|Ensembl=ENSPTRG00000012427|UniProtKB=H2QIN7	Mitogen-activated protein kinase kinase kinase 2	ISS	11730323	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	P01444	Wnt	XENTR|Xenbase=XB-GENE-484098|UniProtKB=F6ZQ88	Protein Wnt (Fragment)	ISS	11266476	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02744	Fructose galactose metabolism	P02964	Hexose 1-P uridyltransferase	THEMA|EnsemblGenome=TM_1191|UniProtKB=O33836	Galactose-1-phosphate uridylyltransferase	NAS	3252900	gi	PTHR11943:SF2	GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	IDA	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	PANTR|Ensembl=ENSPTRG00000005858|UniProtKB=H2Q7J6	Uncharacterized protein	ISS	12441358	PubMed	PTHR24247:SF30	5-HYDROXYTRYPTAMINE RECEPTOR 2A
P00053	T cell activation	P01332	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04397	p53 pathway by glucose deprivation	P04641	Akt	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	ISS	9716402	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	BOVIN|Ensembl=ENSBTAG00000034854|UniProtKB=F1N246	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHICK|Ensembl=ENSGALG00000011086|UniProtKB=P68139	Actin, alpha skeletal muscle	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00034	Integrin signalling pathway	P00944	Actin	MONDO|Ensembl=ENSMODG00000002647|UniProtKB=F7DIB7	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P05918	p38 MAPK pathway	P06031	p38alpha	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	RCA	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00037	Ionotropic glutamate receptor pathway	P01006	NR2C	RAT|RGD=2739|UniProtKB=Q00961	Glutamate receptor ionotropic, NMDA 2C	ISS	14698601	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P04393	Ras Pathway	P04547	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	CANAL|CGD=CAL0000182839|UniProtKB=P78599	Ornithine decarboxylase	ISS			PTHR11482:SF6	ORNITHINE DECARBOXYLASE 1-RELATED
P00029	Huntington disease	P00807	Actin	RAT|RGD=1304556|UniProtKB=P63259	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00019	Endothelin signaling pathway	P00587	Raf-1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IGI	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	HUMAN|HGNC=6264|UniProtKB=P48549	G protein-activated inward rectifier potassium channel 1	IDA	12374786	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00047	PDGF signaling pathway	P01148	Grb2	HUMAN|HGNC=4562|UniProtKB=Q13588	GRB2-related adapter protein	ISS	51702266	gi	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	CAEEL|WormBase=WBGene00004310|UniProtKB=G5EBK8	GTP binding protein	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00020	FAS signaling pathway	P00615	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00036	Interleukin signaling pathway	P00986	eNOS	HUMAN|HGNC=7876|UniProtKB=P29474	Nitric oxide synthase, endothelial	ISS	10435050	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	IC	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	XENTR|Ensembl=ENSXETG00000021375|UniProtKB=F6T423	Uncharacterized protein	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00865	Shc	MOUSE|MGI=MGI=98296|UniProtKB=P98083	SHC-transforming protein 1	ISS	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	CANAL|CGD=CAL0000192612|UniProtKB=P0CY33	Cell division control protein 42 homolog	ISS			PTHR24072:SF192	CDC42 HOMOLOG
P00003	Alzheimer disease-amyloid secretase pathway	P00079	alpha7 nicotinic acetylcholine receptor	HUMAN|HGNC=15781|UniProtKB=Q494W8	CHRNA7-FAM7A fusion protein	IDA			PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	PANTR|Ensembl=ENSPTRG00000004718|UniProtKB=H2Q5I0	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00006	Apoptosis signaling pathway	P00303	c-Jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00021	FGF signaling pathway	P00644	p38	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	8925912	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00005	Angiogenesis	P00243	Raf	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00021	FGF signaling pathway	P00648	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00025	Hedgehog signaling pathway	P00682	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00035	Interferon-gamma signaling pathway	P00952	Jak2	HUMAN|HGNC=6192|UniProtKB=O60674	Tyrosine-protein kinase JAK2	TAS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P02741	Flavin biosynthesis	P02939	Lumazine synthase	DEIRA|EnsemblGenome=DR_0156|UniProtKB=Q9RXZ8	6,7-dimethyl-8-ribityllumazine synthase	ISS			PTHR21058:SF0	6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ORYSJ|EnsemblGenome=OS12G0163700|UniProtKB=Q0IPW3	Os12g0163700 protein	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04393	Ras Pathway	P04557	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00001	Adrenaline and noradrenaline biosynthesis	P00068	amine translocator	MOUSE|MGI=MGI=2143484|UniProtKB=Q8BG16	Sodium-dependent neutral amino acid transporter B(0)AT2	IC	12719981	PubMed	PTHR11616:SF101	SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER B 0 AT2
P06210	Activin beta signaling pathway	P06231	BABO	DROME|FlyBase=FBgn0011300|UniProtKB=A1Z7L8	Receptor protein serine/threonine kinase	IEA	http://flybase.org/reports/FBgn0011300.html	Website	PTHR23255:SF71	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MOUSE|MGI=MGI=95818|UniProtKB=Q61626	Glutamate receptor ionotropic, kainate 5	ISS	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00807	Actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	IDA	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00019	Endothelin signaling pathway	P00586	Gq	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00057	Wnt signaling pathway	P01446	Calcineurin	CANLF|Ensembl=ENSCAFG00000010644|UniProtKB=F2Z4P5	Serine/threonine-protein phosphatase	ISS	12091710	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P06959	CCKR signaling map	P07135	ARHGAP4	HUMAN|HGNC=674|UniProtKB=P98171	Rho GTPase-activating protein 4	RCA	19940064	PubMed	PTHR14166:SF16	RHO GTPASE-ACTIVATING PROTEIN 4
P00049	Parkinson disease	P01230	Src kinase	CHICK|Gene=FYN|UniProtKB=Q05876	Tyrosine-protein kinase Fyn	IDA	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00034	Integrin signalling pathway	P00948	Rho	BOVIN|Ensembl=ENSBTAG00000014299|UniProtKB=Q1RMJ6	Rho-related GTP-binding protein RhoC	ISS	14871999	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P02762	Pentose phosphate pathway	P03071	Ribulose 5-P Isomerase	MOUSE|MGI=MGI=103254|UniProtKB=P47968	Ribose-5-phosphate isomerase	RCA			PTHR11934:SF0	RIBOSE-5-PHOSPHATE ISOMERASE
P00047	PDGF signaling pathway	P01153	GSK3	MOUSE|MGI=MGI=2152453|UniProtKB=Q2NL51	Glycogen synthase kinase-3 alpha	ISS	21361340	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00019	Endothelin signaling pathway	P00568	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	ORYSJ|Gene=Os01g0866100|UniProtKB=P0C540	Actin-7	IC	14684598	PubMed	PTHR11937:SF205	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CAEBR|Gene=CBG18319|UniProtKB=A8XSF1	Protein CBR-TBB-1	ISS	12932731	PubMed	PTHR11588:SF157	TUBULIN, BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P05912	Dopamine receptor mediated signaling pathway	P05949	Grb2	XENTR|Xenbase=XB-GENE-6070000|UniProtKB=Q66II3	Growth factor receptor-bound protein 2	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	HUMAN|HGNC=11772|UniProtKB=P36897	TGF-beta receptor type-1	TAS	9395284	PubMed	PTHR23255:SF61	TGF-BETA RECEPTOR TYPE-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00848	Grb	RAT|RGD=1306884|UniProtKB=Q4KM68	GRB2-related adaptor protein	ISS	11971956	PubMed	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	97102671	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00048	PI3 kinase pathway	P01193	IRS	MOUSE|MGI=MGI=99454|UniProtKB=P35569	Insulin receptor substrate 1	IDA	11701440	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00048	PI3 kinase pathway	P01202	p85	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CANLF|Gene=GRIN1|UniProtKB=Q5R1P0	Glutamate receptor ionotropic, NMDA 1	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04393	Ras Pathway	P04556	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IDA	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06760	MKK4/7	MOUSE|MGI=MGI=1346869|UniProtKB=P47809	Dual specificity mitogen-activated protein kinase kinase 4	RCA	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01285	TAK	HUMAN|HGNC=6859|UniProtKB=O43318	Mitogen-activated protein kinase kinase kinase 7	RCA			PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P00049	Parkinson disease	P01213	Cyclin E	DANRE|ZFIN=ZDB-GENE-980526-168|UniProtKB=P47794	G1/S-specific cyclin-E1	IDA	12628165	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00021	FGF signaling pathway	P00623	FGF	CANLF|Ensembl=ENSCAFG00000032672|UniProtKB=J9NVW4	Fibroblast growth factor	ISS	97376484	PubMed	PTHR11486:SF77	FIBROBLAST GROWTH FACTOR 13
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	IPI	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P02723	Adenine and hypoxanthine salvage pathway	P02813	Inosine phosphorylase	CAEEL|WormBase=WBGene00019298|UniProtKB=U4PSA1	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IDA	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	ISS	10704417	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	9395335	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02747	Histidine biosynthesis	P02992	Imidazol glycerol phosphate synthase	ARATH|TAIR=AT4G26900|UniProtKB=Q9SZ30	Imidazole glycerol phosphate synthase hisHF, chloroplastic	ISS			PTHR21235:SF2	IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	HUMAN|HGNC=4571|UniProtKB=P42261	Glutamate receptor 1	ISS	10331083	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04542	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00260	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01174	Rho	CANLF|Ensembl=ENSCAFG00000005535|UniProtKB=F1PJZ0	Uncharacterized protein	ISS			PTHR14166:SF8	SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 3
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00539	14-3-3	ORNAN|Ensembl=ENSOANG00000007305|UniProtKB=F6XW91	Uncharacterized protein	ISS	1499718	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00034	Integrin signalling pathway	P00907	ERK	BOVIN|Ensembl=ENSBTAG00000005865|UniProtKB=G5E577	Uncharacterized protein	ISS	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00034	Integrin signalling pathway	P00925	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00029	Huntington disease	P00777	CBP	HUMAN|HGNC=3373|UniProtKB=Q09472	Histone acetyltransferase p300	IDA	10769018	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00029	Huntington disease	P00779	TBP	DICDI|dictyBase=DDB_G0275617|UniProtKB=P26355	TATA-box-binding protein	IPI	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00029	Huntington disease	P00807	Actin	CAEBR|Gene=CBG18256|UniProtKB=A8XS95	Protein CBR-ACT-5	ISS	14684598	PubMed	PTHR11937:SF352	ACTIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	ARATH|TAIR=AT1G60430|UniProtKB=Q1ECJ7	Actin-related protein 2/3 complex subunit 3	ISS			PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	RAT|RGD=67385|UniProtKB=Q8VGC3	Voltage-dependent L-type calcium channel subunit beta-2	IC	20088160	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	TAS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P06216	SCW signaling pathway	P06323	MED	DROME|FlyBase=FBgn0011648|UniProtKB=P42003	Protein mothers against dpp	RCA			PTHR13703:SF40	PROTEIN MOTHERS AGAINST DPP
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00017	DNA replication	P00527	Histones	CAEEL|WormBase=WBGene00001876|UniProtKB=P08898	Histone H3	ISS	20448842	PubMed	PTHR11426:SF167	HISTONE H3.1
P05916	Opioid prodynorphin pathway	P06002	G-protein	DAPPU|EnsemblGenome=DAPPUDRAFT_59367|UniProtKB=E9H7Z0	Guanine nucleotide-binding protein G(O) subunit alpha 1	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04393	Ras Pathway	P04546	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04393	Ras Pathway	P04566	Stat 1/3	CHICK|Ensembl=ENSGALG00000003267|UniProtKB=Q6DV79	Signal transducer and activator of transcription 3	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00005	Angiogenesis	P00181	SHP2	CANLF|Ensembl=ENSCAFG00000008894|UniProtKB=F1Q3J6	Tyrosine-protein phosphatase non-receptor type	ISS	8096088	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DANRE|ZFIN=ZDB-GENE-040426-1489|UniProtKB=Q6PHV0	Syntaxin 3A	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P02728	Arginine biosynthesis	P02847	N-actetylornithine deacetylase	DEIRA|EnsemblGenome=DR_2025|UniProtKB=Q9RSU7	ArgE/DapE/Acy1 family protein	ISS			PTHR43270:SF4	RE11562P
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DICPU|Gene=DICPUDRAFT_90232|UniProtKB=F1A175	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00018	EGF receptor signaling pathway	P00563	Gab	CANLF|Ensembl=ENSCAFG00000003613|UniProtKB=F1P7F6	Uncharacterized protein	ISS	15356145	PubMed	PTHR12156:SF18	GRB2-ASSOCIATED-BINDING PROTEIN 1
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MOUSE|MGI=MGI=1915021|UniProtKB=Q9CPW4	Actin-related protein 2/3 complex subunit 5	ISS	12473693	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00034	Integrin signalling pathway	P00920	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04393	Ras Pathway	P04557	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00006	Apoptosis signaling pathway	P00310	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04544	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	9763606	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MACMU|Ensembl=ENSMMUG00000022937|UniProtKB=F6U717	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P04393	Ras Pathway	P04561	SRF	MACMU|Ensembl=ENSMMUG00000000033|UniProtKB=F7G4D2	Uncharacterized protein	ISS	15647354	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P02738	De novo purine biosynthesis	P02891	GDP kinase	PYRAE|EnsemblGenome=PAE1561|UniProtKB=Q8ZWY4	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00010	B cell activation	P00392	I kappa B	MOUSE|MGI=MGI=104741|UniProtKB=Q9Z1E3	NF-kappa-B inhibitor alpha	ISS	12637573	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00048	PI3 kinase pathway	P01202	p85	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	IDA	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00053	T cell activation	P01307	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P02785	Valine biosynthesis	P03215	Branched chain amino acid aminotransferase	BOVIN|Ensembl=ENSBTAG00000013825|UniProtKB=A4IFQ7	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF51	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, CYTOSOLIC
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	PANTR|Ensembl=ENSPTRG00000020891|UniProtKB=H2QX72	Uncharacterized protein	ISS	11801633	PubMed	PTHR12015:SF72	C-C MOTIF CHEMOKINE 21
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	RAT|RGD=2869|UniProtKB=P24062	Insulin-like growth factor 1 receptor	ISS	11182407	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00018	EGF receptor signaling pathway	P00557	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05731	GABA-B receptor II signaling	P05760	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00046	Oxidative stress response	P01129	JNK1/2	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00046	Oxidative stress response	P01135	p38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01312	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	CANLF|Ensembl=ENSCAFG00000013778|UniProtKB=F6UQ33	Phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00053	T cell activation	P01336	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IGI	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	IC	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	IDA	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00034	Integrin signalling pathway	P00944	Actin	MOUSE|MGI=MGI=87906|UniProtKB=P63260	Actin, cytoplasmic 2	ISS	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P04396	Vitamin D metabolism and pathway	P04602	RXR	CANLF|Gene=RARA|UniProtKB=Q5FBR4	Retinoic acid receptor alpha	ISS			PTHR24082:SF115	RETINOIC ACID RECEPTOR ALPHA
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00049	Parkinson disease	P01227	20S proteasome	DANRE|ZFIN=ZDB-GENE-040625-96|UniProtKB=Q6TGV6	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF14	PROTEASOME SUBUNIT ALPHA TYPE-5
P00003	Alzheimer disease-amyloid secretase pathway	P00107	kinesin	MONDO|Ensembl=ENSMODG00000018988|UniProtKB=F7FP03	Uncharacterized protein	ISS	11740561	PubMed	PTHR19959:SF139	KINESIN LIGHT CHAIN 4
P00022	General transcription by RNA polymerase I	P00650	TAF-IB	DANRE|ZFIN=ZDB-GENE-040426-1013|UniProtKB=Q6P0T2	Transcription initiation factor TFIID subunit 8	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P06959	CCKR signaling map	P07038	14-3-3 beta/alpha	HUMAN|HGNC=12849|UniProtKB=P31946	14-3-3 protein beta/alpha	RCA	9069260	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00021	FGF signaling pathway	P00640	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	MACMU|Ensembl=ENSMMUG00000009885|UniProtKB=F6YL51	Uncharacterized protein	ISS	11907044	PubMed	PTHR44025:SF7	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00015	Circadian clock system	G01501	cry	XENTR|Xenbase=XB-GENE-946007|UniProtKB=F6X865	Uncharacterized protein	ISS			PTHR11455:SF16	CRYPTOCHROME-1
P00034	Integrin signalling pathway	P00919	Arf6	HUMAN|HGNC=659|UniProtKB=P62330	ADP-ribosylation factor 6	IPI	12932731	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_94959|UniProtKB=C3XYC4	Putative uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00021	FGF signaling pathway	P00643	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00009	Axon guidance mediated by netrin	P00363	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01142	p90RSK	MONDO|Ensembl=ENSMODG00000014313|UniProtKB=F7BTW0	Ribosomal protein S6 kinase	ISS	11861821	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01470	Frodo	RAT|RGD=1564008|UniProtKB=D4A3W8	Protein Dact1	RCA			PTHR15919:SF12	DAPPER HOMOLOG 1
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	BOVIN|Ensembl=ENSBTAG00000016629|UniProtKB=E1BM79	Adenylyl CYclase family member (Acy-1)-like	ISS	2491850	PubMed	PTHR11920:SF319	ADENYLATE CYCLASE TYPE 9
P00011	Blood coagulation	P00458	GP IIIa	CANLF|Ensembl=ENSCAFG00000013735|UniProtKB=F1PPG5	Integrin beta	ISS	124968	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00034	Integrin signalling pathway	P00907	ERK	MACMU|Ensembl=ENSMMUG00000008503|UniProtKB=F6TGJ6	Uncharacterized protein	ISS	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	IC	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	HUMAN|HGNC=417|UniProtKB=P05062	Fructose-bisphosphate aldolase B	ISS	8086469	PubMed	PTHR11627:SF2	FRUCTOSE-BISPHOSPHATE ALDOLASE B
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05913	Enkephalin release	P05972	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00020	FAS signaling pathway	P00620	CytochromeC	CAEBR|Gene=CBG08212|UniProtKB=A8X623	Protein CBR-CYC-1	ISS	9027315	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00057	Wnt signaling pathway	P01465	Ggamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00005	Angiogenesis	P00199	JNKK1	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=1763|UniProtKB=P55283	Cadherin-4	IDA	8120095	PubMed	PTHR24027:SF81	CADHERIN-4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	DROME|FlyBase=FBgn0004623|UniProtKB=P29829	Guanine nucleotide-binding protein subunit beta-2	IC			PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	SCHPO|PomBase=SPCC1259.06|UniProtKB=O94706	Transcription initiation factor TFIID subunit 8	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00010	B cell activation	P00373	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04397	p53 pathway by glucose deprivation	P04636	S6K	HUMAN|HGNC=10436|UniProtKB=P23443	Ribosomal protein S6 kinase beta-1	IDA	15116068	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04398	p53 pathway feedback loops 2	P04657	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	10644715	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DROME|FlyBase=FBgn0261854|UniProtKB=A1Z9X0	Atypical protein kinase C	ISS	3755548	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00021	FGF signaling pathway	P00629	PP2A	MONDO|Ensembl=ENSMODG00000019007|UniProtKB=F7C5Z9	Uncharacterized protein	ISS	96161994	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00182	p38MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	METAC|EnsemblGenome=MA_1385|UniProtKB=Q8TR00	Aspartate aminotransferase	ISS			PTHR11751:SF430	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	PANTR|Ensembl=ENSPTRG00000018659|UniProtKB=H2QTU5	Uncharacterized protein	ISS	9865691	PubMed	PTHR17045:SF7	CBP/P300-INTERACTING TRANSACTIVATOR 2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00049	Parkinson disease	P01215	Syntaxin	MOUSE|MGI=MGI=1858210|UniProtKB=O70439	Syntaxin-7	ISS	14570579	PubMed	PTHR19957:SF90	SYNTAXIN-7
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05916	Opioid prodynorphin pathway	P06003	dynorphin	PANTR|Ensembl=ENSPTRG00000013172|UniProtKB=H2QJT9	Uncharacterized protein	ISS	131330	OMIM	PTHR11438:SF4	PROENKEPHALIN-B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00942	Fyn	MONDO|Ensembl=ENSMODG00000017905|UniProtKB=F7FG65	Tyrosine-protein kinase	ISS	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	BOVIN|Ensembl=ENSBTAG00000004322|UniProtKB=O77628	Proto-oncogene c-Fos	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04398	p53 pathway feedback loops 2	P04665	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g234494|UniProtKB=A7RU31	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	DANRE|Ensembl=ENSDARG00000015050|UniProtKB=Q6PI52	Calmodulin	ISS	3885394	PubMed	PTHR23050:SF326	CALMODULIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000000271|UniProtKB=Q5IS65	5-hydroxytryptamine receptor 6	ISS			PTHR24247:SF114	5-HYDROXYTRYPTAMINE RECEPTOR 6
P00049	Parkinson disease	P01219	SAPK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	NAS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02744	Fructose galactose metabolism	P02960	Galactokinase	HUMAN|HGNC=4119|UniProtKB=Q01415	N-acetylgalactosamine kinase	ISS			PTHR10457:SF7	N-ACETYLGALACTOSAMINE KINASE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P05915	Opioid proenkephalin pathway	P05990	K+ channel	MONDO|Ensembl=ENSMODG00000015769|UniProtKB=F6ZSC2	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00017	DNA replication	P00527	Histones	TAKRU|Ensembl=ENSTRUG00000004281|UniProtKB=H2SCM3	Uncharacterized protein	ISS	12413958	PubMed	PTHR11426:SF180	SUBFAMILY NOT NAMED
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	MOUSE|MGI=MGI=102891|UniProtKB=P51829	Adenylate cyclase type 7	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MONDO|Ensembl=ENSMODG00000021434|UniProtKB=F7CB49	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANAL|CGD=CAL0003231|UniProtKB=Q5ANK2	Protein kinase C	ISS	125549	gi	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00049	Parkinson disease	P01238	14-3-3	XENTR|Xenbase=XB-GENE-951350|UniProtKB=Q0V9W8	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	ISS	8381897	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P05913	Enkephalin release	P05972	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00249	PAK	MACMU|Ensembl=ENSMMUG00000001387|UniProtKB=F7D0B4	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04570	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00060	Ubiquitin proteasome pathway	P01491	E2	MOUSE|MGI=MGI=102944|UniProtKB=P63147	Ubiquitin-conjugating enzyme E2 B	ISS			PTHR43898:SF6	UBIQUITIN-CONJUGATING ENZYME E2 B
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	HUMAN|HGNC=5465|UniProtKB=P08069	Insulin-like growth factor 1 receptor	ISS	11182407	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00048	PI3 kinase pathway	P01192	p110	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	CHLRE|EnsemblGenome=CHLREDRAFT_24392|UniProtKB=A8JAV1	Actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P06587	Nicotine pharmacodynamics pathway	P06590	GNG	MACMU|Ensembl=ENSMMUG00000010392|UniProtKB=F7ASR8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04393	Ras Pathway	P04543	MEKK1/4	MONDO|Ensembl=ENSMODG00000006594|UniProtKB=F7AKA6	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CAEEL|WormBase=WBGene00004055|UniProtKB=Q17446	Mitogen-activated protein kinase pmk-1	IDA	10514528	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00056	VEGF signaling pathway	P01407	Erk	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01160	IP3 receptor	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04392	P53 pathway feedback loops 1	P04540	Cop-1	MACMU|Ensembl=ENSMMUG00000002072|UniProtKB=F6QR11	E3 ubiquitin-protein ligase RFWD2 isoform a	ISS	15103385	PubMed	PTHR44080:SF1	E3 UBIQUITIN-PROTEIN LIGASE RFWD2
P00036	Interleukin signaling pathway	P00964	p90RSK	CHICK|Ensembl=ENSGALG00000016406|UniProtKB=F1NLJ3	Uncharacterized protein	ISS	10480933	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00046	Oxidative stress response	P01121	MKK3/6	MONDO|Ensembl=ENSMODG00000001404|UniProtKB=F7BD74	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	YEAST|SGD=S000005738|UniProtKB=P18851	Guanine nucleotide-binding protein subunit beta	IC	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00047	PDGF signaling pathway	P01171	PLCgamma	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	ORYSJ|EnsemblGenome=OS11G0312220|UniProtKB=Q08480	Adenylate kinase 4	ISS			PTHR23359:SF22	GTP:AMP PHOSPHOTRANSFERASE, MITOCHONDRIAL
P00046	Oxidative stress response	P01129	JNK1/2	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	RAT|RGD=70487|UniProtKB=Q9WU82	Catenin beta-1	TAS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00021	FGF signaling pathway	P00641	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DICDI|dictyBase=DDB_G0269234|UniProtKB=P07830	Major actin	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00004	Alzheimer disease-presenilin pathway	P00114	actin	HUMAN|HGNC=132|UniProtKB=P60709	Actin, cytoplasmic 1	IDA	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00053	T cell activation	P01300	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05731	GABA-B receptor II signaling	P05760	AC	HUMAN|HGNC=236|UniProtKB=O95622	Adenylate cyclase type 5	ISS	1409703	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00011	Blood coagulation	P00443	Fibrin polymer cross-linked	XENTR|Xenbase=XB-GENE-483216|UniProtKB=B0JZ09	Fgb protein	ISS	95369693	PubMed	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00018	EGF receptor signaling pathway	P00559	MEK1-2	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00049	Parkinson disease	P01230	Src kinase	RAT|RGD=1308859|UniProtKB=Q4KM97	Tyrosine-protein kinase	ISS	9013950	PubMed	PTHR24418:SF181	TYROSINE-PROTEIN KINASE BLK
P00019	Endothelin signaling pathway	P00589	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	XENTR|Xenbase=XB-GENE-488998|UniProtKB=Q5BL41	Actin-related protein 2	ISS	10974003	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00005	Angiogenesis	P00233	CSL	ORNAN|Ensembl=ENSOANG00000006699|UniProtKB=F6ULE6	Uncharacterized protein	ISS	9043084	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P02738	De novo purine biosynthesis	P02898	Phosphoribosylformylglycinamide  synthase	ECOLI|EcoGene=EG10797|UniProtKB=P15254	Phosphoribosylformylglycinamidine synthase	ISS			PTHR10099:SF5	PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE
P04398	p53 pathway feedback loops 2	G04709	MDM-2	HUMAN|HGNC=6973|UniProtKB=Q00987	E3 ubiquitin-protein ligase Mdm2	IGI	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00023	General transcription regulation	P00668	TFIIB	ANOGA|EnsemblGenome=AGAP009558|UniProtKB=Q7QG89	AGAP009558-PA	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05913	Enkephalin release	P05972	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00021	FGF signaling pathway	P00648	PKC	SCHPO|PomBase=SPBC12D12.04c|UniProtKB=P36583	Protein kinase C-like 2	IGI	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04393	Ras Pathway	P04566	Stat 1/3	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	ORNAN|Ensembl=ENSOANG00000013961|UniProtKB=F6VPY1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00018	EGF receptor signaling pathway	P00562	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=7577|UniProtKB=P12883	Myosin-7	IC	89264452	PubMed	PTHR13140:SF344	MYOSIN-7
P00029	Huntington disease	P00790	beta-Tubulin	CHICK|GeneID=431043|UniProtKB=P09652	Tubulin beta-4 chain	TAS	12932731	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	12660731	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DANRE|ZFIN=ZDB-GENE-041001-104|UniProtKB=Q5TZD4	Protein kinase C	ISS	11880265	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00056	VEGF signaling pathway	P01417	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IDA	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	20384797	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	IC	8557110	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00018	EGF receptor signaling pathway	P00562	p38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	IGI	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00011	Blood coagulation	P00423	APC	MOUSE|MGI=MGI=97771|UniProtKB=P33587	Vitamin K-dependent protein C	ISS	6679477	gi	PTHR24278:SF0	VITAMIN K-DEPENDENT PROTEIN C
P04398	p53 pathway feedback loops 2	P04657	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	BOVIN|Gene=SLC1A1|UniProtKB=Q95135	Excitatory amino acid transporter 3	ISS	94365697	PubMed	PTHR11958:SF69	EXCITATORY AMINO ACID TRANSPORTER 3
P00019	Endothelin signaling pathway	P00570	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00029	Huntington disease	P00780	Microtubule	MOUSE|MGI=MGI=1915472|UniProtKB=P68372	Tubulin beta-4B chain	IDA	9454836	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P05913	Enkephalin release	P05974	G-Protein (i)	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02728	Arginine biosynthesis	P02846	Ornithine carbamoyl transferase	METJA|EnsemblGenome=MJ_0881|UniProtKB=Q58291	Ornithine carbamoyltransferase	ISS			PTHR11405:SF1	ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL
P00052	TGF-beta signaling pathway	P01284	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00181	SHP2	RAT|RGD=3447|UniProtKB=P41499	Tyrosine-protein phosphatase non-receptor type 11	ISS	14525967	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00025	Hedgehog signaling pathway	P00682	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00011	Blood coagulation	P00446	FVIIIa	MACMU|Ensembl=ENSMMUG00000010245|UniProtKB=F6QMC6	Uncharacterized protein	ISS	4503647	gi	PTHR45309:SF1	COAGULATION FACTOR VIII
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01440	Cadherin	BOVIN|Ensembl=ENSBTAG00000000061|UniProtKB=E1BCK4	Uncharacterized protein	ISS	8120095	PubMed	PTHR43912:SF8	PROTOCADHERIN-7
P02738	De novo purine biosynthesis	P02909	GDP reductase	DANRE|ZFIN=ZDB-GENE-990415-247|UniProtKB=P79732	Ribonucleoside-diphosphate reductase large subunit	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00049	Parkinson disease	P01227	20S proteasome	TAKRU|Ensembl=ENSTRUG00000007430|UniProtKB=H2T133	Proteasome subunit beta type	ISS	12859888	PubMed	PTHR11599:SF59	PROTEASOME SUBUNIT BETA TYPE-1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01150	PKC	MOUSE|MGI=MGI=109211|UniProtKB=Q8BWW9	Serine/threonine-protein kinase N2	ISS	125549	gi	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00015	Circadian clock system	G01503	per	PANTR|Ensembl=ENSPTRG00000000099|UniProtKB=H2R1W8	Uncharacterized protein	ISS	15700718	PubMed	PTHR11269:SF13	PERIOD CIRCADIAN PROTEIN HOMOLOG 3
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	ARATH|TAIR=AT4G38970|UniProtKB=Q944G9	Probable fructose-bisphosphate aldolase 2, chloroplastic	TAS	18420348	gi	PTHR11627:SF22	FRUCTOSE-BISPHOSPHATE ALDOLASE 1, CHLOROPLASTIC-RELATED
P00005	Angiogenesis	P00243	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00012	Cadherin signaling pathway	P00470	F-actin	XENTR|GeneID=394982|UniProtKB=P20399	Actin, alpha cardiac muscle 2	ISS	14684598	PubMed	PTHR11937:SF263	ACTIN
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04552	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1712|UniProtKB=Q6PBY0	Guanine nucleotide binding protein (G protein), beta 5	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00047	PDGF signaling pathway	P01150	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00006	Apoptosis signaling pathway	P00322	Cytochrome C	DROME|FlyBase=FBgn0086907|UniProtKB=P04657	Cytochrome c-1	ISS			PTHR11961:SF22	CYTOCHROME C-1
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MONDO|Ensembl=ENSMODG00000024440|UniProtKB=F7DJJ2	Muscarinic acetylcholine receptor	ISS	12181435	PubMed	PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	IC	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	CANLF|Ensembl=ENSCAFG00000008517|UniProtKB=E2R3J4	Uncharacterized protein	ISS			PTHR12458:SF8	CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20
P00046	Oxidative stress response	P01135	p38	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00021	FGF signaling pathway	P00634	MEKK1-5	PANTR|Ensembl=ENSPTRG00000012427|UniProtKB=H2QIN7	Mitogen-activated protein kinase kinase kinase 2	ISS	11730323	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00053	T cell activation	P01311	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IGI	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00012	Cadherin signaling pathway	P00475	Frizzled	DROME|FlyBase=FBgn0001085|UniProtKB=P18537	Frizzled	IDA	11212302	PubMed	PTHR11309:SF47	FRIZZLED
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04393	Ras Pathway	P04546	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IDA	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00049	Parkinson disease	P01211	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06812	L-type Ca2+	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	RCA	15621031	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00030	Hypoxia response via HIF activation	P00819	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01174	Rho	RAT|RGD=1566016|UniProtKB=D4A208	SLIT-ROBO Rho GTPase-activating protein 2	ISS			PTHR14166:SF6	SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 2-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01392	TFIIH complex	BOVIN|Ensembl=ENSBTAG00000046757|UniProtKB=A6H7G8	GTF2H4 protein	ISS			PTHR13152:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00021	FGF signaling pathway	P00640	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	IGI	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00759	PDEalphabeta	CANLF|Ensembl=ENSCAFG00000016782|UniProtKB=P33726	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	ISS			PTHR11347:SF73	ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00559	MEK1-2	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00629	PP2A	PANTR|Ensembl=ENSPTRG00000017377|UniProtKB=H2RCR7	Uncharacterized protein	ISS	12716901	PubMed	PTHR11871:SF1	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05923	beta-ARR2	PANTR|Ensembl=ENSPTRG00000008601|UniProtKB=H2QBY1	Arrestin, beta 2	ISS	12464600	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	MOUSE|MGI=MGI=95602|UniProtKB=P39688	Tyrosine-protein kinase Fyn	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00010	B cell activation	P00371	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00629	PP2A	MOUSE|MGI=MGI=1321161|UniProtKB=P62715	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P02743	Formyltetrahydroformate biosynthesis	P02954	Thymidylate synthase	DEIRA|EnsemblGenome=DR_2630|UniProtKB=Q9RR67	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00062	TH	BOVIN|Gene=TH|UniProtKB=P17289	Tyrosine 3-monooxygenase	ISS	12814656	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00029	Huntington disease	P00768	Apaf-1	BOVIN|Ensembl=ENSBTAG00000021661|UniProtKB=F1MUW4	Apoptotic protease-activating factor 1	ISS	14526190	PubMed	PTHR22845:SF5	APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	G06683	miR-132/212	MOUSE|MGI=MGI=96244|UniProtKB=Q61696	Heat shock 70 kDa protein 1A	RCA	12150907	PubMed	PTHR19375:SF223	HEAT SHOCK 70 KDA PROTEIN 1A-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	RAT|RGD=621005|UniProtKB=Q08849	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	BOVIN|Gene=ARPC5|UniProtKB=Q3SYX9	Actin-related protein 2/3 complex subunit 5	IDA	12932731	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00046	Oxidative stress response	P01129	JNK1/2	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00010	B cell activation	P00375	Calmodulin	PHYPA|Gene=PHYPADRAFT_210000|UniProtKB=A9S9L5	Predicted protein	ISS			PTHR23050:SF245	AT16150P-RELATED
P04393	Ras Pathway	P04558	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	IDA	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00023	General transcription regulation	P00662	TFIIA complex	MOUSE|MGI=MGI=1919078|UniProtKB=Q8R4I4	TFIIA-alpha and beta-like factor	ISS			PTHR12694:SF9	PROTEIN STON1-GTF2A1L-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	RCA	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04393	Ras Pathway	P04546	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04393	Ras Pathway	P04570	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00923	Arf1	IXOSC|EnsemblGenome=ISCW022927|UniProtKB=B7QCW2	ADP-ribosylation factor	ISS	12932731	PubMed	PTHR11711:SF304	ADP-RIBOSYLATION FACTOR 1
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	RAT|RGD=69319|UniProtKB=P54313	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00045	Notch signaling pathway	P01115	Neurotic	MACMU|Ensembl=ENSMMUG00000013848|UniProtKB=F7BVV0	Alpha-(1,6)-fucosyltransferase	ISS			PTHR13132:SF29	ALPHA- 1,6 -FUCOSYLTRANSFERASE
P00057	Wnt signaling pathway	P01451	Galpha	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	IDA	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00021	FGF signaling pathway	P00624	14-3-3	YEAST|SGD=S000000979|UniProtKB=P29311	Protein BMH1	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00010	B cell activation	P00384	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	ARATH|TAIR=AT3G47220|UniProtKB=Q6NMA7	Phosphoinositide phospholipase C 9	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00053	T cell activation	P01300	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04552	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00059	p53 pathway	P04633	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01160	IP3 receptor	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P06664	Gonadotropin-releasing hormone receptor pathway	P06847	JNK1/2	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	RCA	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MOUSE|MGI=MGI=106923|UniProtKB=Q62381	Tolloid-like protein 1	TAS	9759503	PubMed	PTHR43978:SF4	TOLLOID-LIKE PROTEIN 1
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1693|UniProtKB=Q6P967	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00059	p53 pathway	G01565	PERP	MACMU|Ensembl=ENSMMUG00000000997|UniProtKB=F6SQT8	Uncharacterized protein	ISS			PTHR14399:SF4	P53 APOPTOSIS EFFECTOR RELATED TO PMP-22
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2049|UniProtKB=P30543	Adenosine receptor A2a	IDA			PTHR24246:SF27	ADENOSINE RECEPTOR A2A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MONDO|Ensembl=ENSMODG00000007194|UniProtKB=F6X9N6	Actin-related protein 2/3 complex subunit 5	ISS	12473693	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P04393	Ras Pathway	P04558	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00054	Toll receptor signaling pathway	P01375	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000016752|UniProtKB=H2QQP5	Cadherin 18, type 2	ISS	8120095	PubMed	PTHR24027:SF106	CADHERIN-18
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IDA	15572354	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00047	PDGF signaling pathway	P01171	PLCgamma	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00013	Cell cycle	P00483	Cyclin E	HUMAN|HGNC=1589|UniProtKB=P24864	G1/S-specific cyclin-E1	IPI	12729791	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00021	FGF signaling pathway	P00646	RasGAP	HUMAN|HGNC=23181|UniProtKB=O43374	Ras GTPase-activating protein 4	ISS	6635197	gi	PTHR10194:SF4	RAS GTPASE-ACTIVATING PROTEIN 4-RELATED
P00018	EGF receptor signaling pathway	P00552	Ras	DAPPU|EnsemblGenome=DAPPUDRAFT_301818|UniProtKB=E9I1I7	Putative uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00144	Ire-1	ARATH|TAIR=AT2G17520|UniProtKB=Q9C5S2	Serine/threonine-protein kinase/endoribonuclease IRE1a	IDA	10619423	PubMed	PTHR13954:SF6	INOSITOL-REQUIRING ENZYME-1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00034	Integrin signalling pathway	P00907	ERK	CANLF|Ensembl=ENSCAFG00000015640|UniProtKB=E2QVF3	Uncharacterized protein	ISS	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00048	PI3 kinase pathway	P01199	Galpha	MOUSE|MGI=MGI=95779|UniProtKB=P50149	Guanine nucleotide-binding protein G(t) subunit alpha-2	ISS			PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00047	PDGF signaling pathway	P01161	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02734	Chorismate biosynthesis	P02872	3-Dehydroquinate synthase	BACSU|EnsemblGenome=BSU22700|UniProtKB=P31102	3-dehydroquinate synthase	ISS			PTHR43622:SF1	3-DEHYDROQUINATE SYNTHASE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	IC	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00046	Oxidative stress response	P01121	MKK3/6	CHICK|Ensembl=ENSGALG00000004735|UniProtKB=F1NHE1	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05915	Opioid proenkephalin pathway	P05992	met-Enkephalin	RAT|RGD=68946|UniProtKB=P04094	Proenkephalin-A	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00059	p53 pathway	P04633	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01329	CD45	CHICK|Ensembl=ENSGALG00000002192|UniProtKB=F1NVB1	Uncharacterized protein	IGI	8940015	PubMed	PTHR19134:SF284	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00029	Huntington disease	P00796	Kainate receptor	BOVIN|Ensembl=ENSBTAG00000033153|UniProtKB=F1MG21	Uncharacterized protein	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00589	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02775	Salvage pyrimidine ribonucleotides	P03151	Uracil phosphoribosyl  transferase	DROME|FlyBase=FBgn0035639|UniProtKB=M9PHI7	CG5537, isoform B	ISS			PTHR10285:SF90	URACIL PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00012	Cadherin signaling pathway	P00474	Wnt	ANOGA|EnsemblGenome=AGAP009731|UniProtKB=Q7PM77	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF98	PROTEIN WNT-RELATED
P00018	EGF receptor signaling pathway	P00560	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00018	EGF receptor signaling pathway	P00564	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	PANTR|Ensembl=ENSPTRG00000017551|UniProtKB=P60021	Histamine H2 receptor	ISS	11841575	PubMed	PTHR43893:SF5	HISTAMINE H2 RECEPTOR
P00056	VEGF signaling pathway	P01413	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	ISS	14526383	PubMed	PTHR10048:SF14	PI-3 KINASE
P00053	T cell activation	P01336	Jnk	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00011	Blood coagulation	P00443	Fibrin polymer cross-linked	RAT|RGD=2603|UniProtKB=P06399	Fibrinogen alpha chain	ISS	1706800	gi	PTHR19143:SF232	FIBRINOGEN ALPHA CHAIN
P05731	GABA-B receptor II signaling	P05755	Gbeta	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00036	Interleukin signaling pathway	P00968	Ikk	HUMAN|HGNC=5960|UniProtKB=O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	IC	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P02738	De novo purine biosynthesis	P02907	dADP kinase	RAT|RGD=70497|UniProtKB=Q05982	Nucleoside diphosphate kinase A	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CANLF|Ensembl=ENSCAFG00000008756|UniProtKB=F2Z4N8	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00053	T cell activation	P01312	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IC	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MACMU|Ensembl=ENSMMUG00000007027|UniProtKB=F7F210	Alpha-cardiac actin	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01306	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00037	Ionotropic glutamate receptor pathway	P01018	Glu1	MONDO|Ensembl=ENSMODG00000008900|UniProtKB=F7B4C1	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	XENTR|Xenbase=XB-GENE-967585|UniProtKB=Q28BZ0	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000007084|UniProtKB=H2Q9G5	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00036	Interleukin signaling pathway	P00990	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00123	CD44 C-terminal fragment	MOUSE|MGI=MGI=88338|UniProtKB=P15379	CD44 antigen	IDA	12223485	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	10395542	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00021	FGF signaling pathway	P00642	MEK1-2	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	TAS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05964	GNAZ	XENTR|Xenbase=XB-GENE-980745|UniProtKB=Q05B25	Uncharacterized protein	ISS	16814816	PubMed	PTHR10218:SF65	GUANINE NUCLEOTIDE-BINDING PROTEIN G Z  SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS	12606638	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00010	B cell activation	P00402	Jnk	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IDA	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IDA	10747026	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	MOUSE|MGI=MGI=97852|UniProtKB=P62835	Ras-related protein Rap-1A	ISS	10476970	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00006	Apoptosis signaling pathway	P00310	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	IDA	1171954	gi	PTHR10048:SF14	PI-3 KINASE
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	HUMAN|HGNC=4040|UniProtKB=Q14332	Frizzled-2	TAS	11212302	PubMed	PTHR11309:SF34	FRIZZLED-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	BOVIN|Ensembl=ENSBTAG00000024507|UniProtKB=E1BNF2	Uncharacterized protein	ISS	2433589	PubMed	PTHR11767:SF17	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 3
P00018	EGF receptor signaling pathway	P00561	STAT	MONDO|Ensembl=ENSMODG00000028212|UniProtKB=F7BYN4	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00059	p53 pathway	G01579	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=1336171|UniProtKB=Q9DAS9	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00717	Phosphorylase b	MOUSE|MGI=MGI=97829|UniProtKB=Q9ET01	Glycogen phosphorylase, liver form	IDA	4318782	PubMed	PTHR11468:SF12	GLYCOGEN PHOSPHORYLASE, LIVER FORM
P00011	Blood coagulation	P00453	FXIII	MACMU|Ensembl=ENSMMUG00000000244|UniProtKB=F6XAB8	Uncharacterized protein	ISS	9961357	gi	PTHR19325:SF314	COAGULATION FACTOR XIII B CHAIN
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	IGI	93028473	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00018	EGF receptor signaling pathway	P00539	14-3-3	ORNAN|Ensembl=ENSOANG00000004145|UniProtKB=F7A0H3	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	RAT|RGD=2732|UniProtKB=P22756	Glutamate receptor ionotropic, kainate 1	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=107924|UniProtKB=Q64527	Protein Wnt-8a	TAS	11266476	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P00018	EGF receptor signaling pathway	P00561	STAT	MONDO|Ensembl=ENSMODG00000028212|UniProtKB=F7BYN4	Signal transducer and activator of transcription	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P02741	Flavin biosynthesis	P02940	Riboflavin synthase	SCHPO|PomBase=SPCC1450.13c|UniProtKB=Q9Y7P0	Riboflavin synthase	ISS			PTHR21098:SF0	RIBOFLAVIN SYNTHASE
P00029	Huntington disease	P00807	Actin	PRIPA|Gene=PPA23459|UniProtKB=H3FMF2	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00054	Toll receptor signaling pathway	P01375	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT4G01370|UniProtKB=Q39024	Mitogen-activated protein kinase 4	IDA	12787066	PubMed	PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	DANRE|ZFIN=ZDB-GENE-010406-5|UniProtKB=A2BGQ1	Uncharacterized protein	ISS			PTHR22778:SF37	SUBFAMILY NOT NAMED
P00045	Notch signaling pathway	P01110	Presenilin	RAT|RGD=3425|UniProtKB=P97887	Presenilin-1	IEP	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00049	Parkinson disease	P01235	Fyn kinase	TAKRU|Ensembl=ENSTRUG00000014739|UniProtKB=H2UL58	Tyrosine-protein kinase	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P04398	p53 pathway feedback loops 2	P04664	cyclin E	RAT|RGD=2294|UniProtKB=P39949	G1/S-specific cyclin-E1	NAS	12628165	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	CAEEL|WormBase=WBGene00000295|UniProtKB=Q9GNP0	Uncharacterized protein	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P06215	MYO signaling pathway	P06313	SARA	DROME|FlyBase=FBgn0026369|UniProtKB=Q7K9H6	FI05490p	IEA	http://flybase.org/reports/FBgn0026369.html	Website	PTHR22835:SF299	FI05490P
P04398	p53 pathway feedback loops 2	P04665	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00059	p53 pathway	G04702	p53	HUMAN|HGNC=15979|UniProtKB=Q9H3D4	Tumor protein 63	TAS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	CAEEL|WormBase=WBGene00011867|UniProtKB=P34574	Probable clathrin heavy chain 1	IDA	9388255	PubMed	PTHR10292:SF1	CLATHRIN HEAVY CHAIN
P05913	Enkephalin release	P05972	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04555	PDK	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	11256888	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	TAS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TAKRU|Ensembl=ENSTRUG00000005447|UniProtKB=P68142	Actin, cytoplasmic 1	IC	10974003	PubMed	PTHR11937:SF354	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00805	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	MONDO|Ensembl=ENSMODG00000018204|UniProtKB=F6PGX6	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	HUMAN|HGNC=4586|UniProtKB=Q13224	Glutamate receptor ionotropic, NMDA 2B	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01452	NFAT	RAT|RGD=1308692|UniProtKB=A0A0G2JTY4	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 (Predicted), isoform CRA_b	ISS	9133421	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00038	JAK/STAT signaling pathway	P01027	STAT	MACMU|Ensembl=ENSMMUG00000010707|UniProtKB=F7G8G5	Signal transducer and activator of transcription	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00006	Apoptosis signaling pathway	P00298	Caspase 9	PANTR|Ensembl=ENSPTRG00000000200|UniProtKB=H2PY35	Caspase	ISS	9390557	PubMed	PTHR10454:SF157	CASPASE-9
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P02723	Adenine and hypoxanthine salvage pathway	P02813	Inosine phosphorylase	MOUSE|MGI=MGI=97365|UniProtKB=P23492	Purine nucleoside phosphorylase	ISS	7903568	PubMed	PTHR11904:SF12	PURINE NUCLEOSIDE PHOSPHORYLASE
P00047	PDGF signaling pathway	P01153	GSK3	PANTR|Ensembl=ENSPTRG00000011049|UniProtKB=H2QGF9	Glycogen synthase kinase 3 alpha	ISS	21361340	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	XENTR|Xenbase=XB-GENE-6050844|UniProtKB=F6WNJ9	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00046	Oxidative stress response	P01129	JNK1/2	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00754	PDEgamma	HUMAN|HGNC=8789|UniProtKB=P18545	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	ISS	P54827	SPACC	PTHR12122:SF4	RETINAL ROD RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT GAMMA
P00034	Integrin signalling pathway	P00941	Integrin alpha	BOVIN|Ensembl=ENSBTAG00000019498|UniProtKB=F1MMS9	Integrin alpha-3	ISS	3487386	PubMed	PTHR23220:SF89	INTEGRIN ALPHA-3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	RCA	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00011	Blood coagulation	P00438	Bradykinin	HUMAN|HGNC=6383|UniProtKB=P01042	Kininogen-1	ISS	386852	gi	PTHR13814:SF12	KININOGEN-1
P00038	JAK/STAT signaling pathway	P01027	STAT	MACMU|Ensembl=ENSMMUG00000010707|UniProtKB=F7G8G5	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04393	Ras Pathway	P04564	MAPKAP	RAT|RGD=1304980|UniProtKB=Q66H84	MAP kinase-activated protein kinase 3	IDA	11335727	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ORNAN|Ensembl=ENSOANG00000007581|UniProtKB=F6QWB7	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	PANTR|Ensembl=ENSPTRG00000014576|UniProtKB=H2QLZ9	Uncharacterized protein	ISS			PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IGI	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00018	EGF receptor signaling pathway	P00551	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00009	Axon guidance mediated by netrin	P00359	NFAT	BOVIN|Ensembl=ENSBTAG00000018270|UniProtKB=F1MGR9	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00005	Angiogenesis	P00198	Survivin	CANLF|Ensembl=ENSCAFG00000005302|UniProtKB=Q8I009	Baculoviral IAP repeat-containing protein 5	ISS	9256286	PubMed	PTHR10044:SF99	BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	TAS			PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MONDO|Ensembl=ENSMODG00000023470|UniProtKB=F6T6U1	Uncharacterized protein	ISS	12441358	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	NEUCR|EnsemblGenome=EFNCRG00000003893|UniProtKB=P78711	Actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04384	Gamma-aminobutyric acid synthesis	P04482	Glutamate decarboxylase	MACMU|Ensembl=ENSMMUG00000012233|UniProtKB=F6VEZ9	Glutamate decarboxylase 2	ISS	2247446	PubMed	PTHR11999:SF77	GLUTAMATE DECARBOXYLASE 2
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00019	Endothelin signaling pathway	P00591	PLCbeta	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IGI	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00020	FAS signaling pathway	P00615	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P06959	CCKR signaling map	P07232	CREB1	HUMAN|HGNC=2345|UniProtKB=P16220	Cyclic AMP-responsive element-binding protein 1	RCA	9770464	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P04393	Ras Pathway	P04542	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00060	Ubiquitin proteasome pathway	P01491	E2	HUMAN|HGNC=12474|UniProtKB=P51668	Ubiquitin-conjugating enzyme E2 D1	ISS			PTHR24068:SF36	UBIQUITIN-CONJUGATING ENZYME E2 D1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	PANTR|Gene=CHRM2|UniProtKB=Q9N2A7	Muscarinic acetylcholine receptor M2 (Fragment)	ISS	10069496	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	MONDO|Ensembl=ENSMODG00000020981|UniProtKB=F6S570	Uncharacterized protein	ISS	2433589	PubMed	PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01275	P38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	TAS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	IXOSC|EnsemblGenome=ISCW009711|UniProtKB=B7Q3T6	THO complex subunit, putative	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	MONDO|Ensembl=ENSMODG00000003295|UniProtKB=F7EG01	Serine/threonine-protein kinase receptor	ISS	9395284	PubMed	PTHR23255:SF64	ACTIVIN RECEPTOR TYPE-2A
P00034	Integrin signalling pathway	P00913	Csk	MOUSE|MGI=MGI=88537|UniProtKB=P41241	Tyrosine-protein kinase CSK	IDA	7687537	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00047	PDGF signaling pathway	P01146	Ikk	RAT|RGD=1306661|UniProtKB=G3V926	Conserved helix-loop-helix ubiquitous kinase (Predicted)	RCA			PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01408	Akt/PKB	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00007	Axon guidance mediated by semaphorins	P00333	RhoGEF	HUMAN|HGNC=681|UniProtKB=Q92888	Rho guanine nucleotide exchange factor 1	ISS	12123608	PubMed	PTHR12673:SF122	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 1
P00036	Interleukin signaling pathway	P00997	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	7798194	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00561	STAT	MACMU|Ensembl=ENSMMUG00000010705|UniProtKB=F7G8V4	Signal transducer and activator of transcription	ISS	14662325	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PRIPA|Gene=PPA21756|UniProtKB=H3FHK9	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF255	TUBA7L PROTEIN
P00015	Circadian clock system	G01497	cry	HUMAN|HGNC=2384|UniProtKB=Q16526	Cryptochrome-1	IEP	14507900	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P02779	Thiamin biosynthesis	P03175	1-Deoxyxylulose-5-phosphate synthase	MYCTU|EnsemblGenome=LH57_18455|UniProtKB=O50408	1-deoxy-D-xylulose-5-phosphate synthase	ISS			PTHR43322:SF6	1-DEOXY-D-XYLULOSE-5-PHOSPHATE SYNTHASE
P00054	Toll receptor signaling pathway	P01340	TLR3	PANTR|Ensembl=ENSPTRG00000016658|UniProtKB=B3Y620	Toll-like receptor 3	ISS			PTHR44599:SF1	TOLL-LIKE RECEPTOR 3
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IGI	7937853	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	TAS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	CHICK|Ensembl=ENSGALG00000011809|UniProtKB=F1NMB0	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00029	Huntington disease	P00801	Fos protein	RAT|RGD=2626|UniProtKB=P12841	Proto-oncogene c-Fos	TAS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00030	Hypoxia response via HIF activation	P00819	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01152	RasGAP	BOVIN|Ensembl=ENSBTAG00000005448|UniProtKB=F1N4Y6	Uncharacterized protein	ISS	6635197	gi	PTHR10194:SF4	RAS GTPASE-ACTIVATING PROTEIN 4-RELATED
P00021	FGF signaling pathway	P00647	SHP2	RAT|RGD=3447|UniProtKB=P41499	Tyrosine-protein phosphatase non-receptor type 11	IGI	1382983	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00021	FGF signaling pathway	P00641	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04393	Ras Pathway	P04542	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01461	FrzB	PANTR|Ensembl=ENSPTRG00000012708|UniProtKB=H2QJ36	Frizzled-related protein	ISS	9118218	PubMed	PTHR11309:SF97	SECRETED FRIZZLED-RELATED PROTEIN 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05913	Enkephalin release	P05972	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	DEIRA|EnsemblGenome=DR_A0348|UniProtKB=Q9RYG9	Aldehyde dehydrogenase	IC			PTHR43111:SF1	ALDEHYDE DEHYDROGENASE B
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00774	Dynein complex	RAT|RGD=619860|UniProtKB=Q78P75	Dynein light chain 2, cytoplasmic	ISS	9454836	PubMed	PTHR11886:SF35	DYNEIN LIGHT CHAIN 2, CYTOPLASMIC
P00021	FGF signaling pathway	P00648	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00010	B cell activation	P00397	IKK	RAT|RGD=1306661|UniProtKB=G3V926	Conserved helix-loop-helix ubiquitous kinase (Predicted)	ISS	9346484	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DICPU|Gene=DICPUDRAFT_48914|UniProtKB=F0ZK40	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF154	ACTIN-17-RELATED
P00048	PI3 kinase pathway	P01192	p110	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05730	Endogenous cannabinoid signaling	P05751	Galpha	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05924	AT1-R	MACMU|Ensembl=ENSMMUG00000020680|UniProtKB=F6WLD6	Uncharacterized protein	ISS			PTHR24228:SF11	TYPE-1 ANGIOTENSIN II RECEPTOR
P02772	Pyruvate metabolism	P03133	Pyruvate Dehydrogenase	STRCO|Gene=CAB99150|UniProtKB=Q9K3H0	Putative pyruvate dehydrogenase alpha subunit	ISS	21219778	gi	PTHR11516:SF2	SUBFAMILY NOT NAMED
P04395	Vasopressin synthesis	P04590	Vasopressin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P02740	De novo pyrimidine ribonucleotides biosythesis	P02928	Dihydroorotase	AQUAE|EnsemblGenome=aq_806|UniProtKB=O66990	Dihydroorotase	ISS			PTHR43668:SF1	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00373	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00021	FGF signaling pathway	P00645	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00054	Toll receptor signaling pathway	P01351	TLR2,4,7	BOVIN|Gene=TLR2|UniProtKB=Q95LA9	Toll-like receptor 2	ISS			PTHR24365:SF17	TOLL-LIKE RECEPTOR 2
P02740	De novo pyrimidine ribonucleotides biosythesis	P02927	Dihydrooratate oxidase	MYCTU|EnsemblGenome=Rv2139|UniProtKB=P9WHL1	Dihydroorotate dehydrogenase (quinone)	ISS			PTHR43517:SF1	DIHYDROOROTATE DEHYDROGENASE  QUINONE , MITOCHONDRIAL
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	IC	10074940	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	7492337	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	CHICK|Ensembl=ENSGALG00000001334|UniProtKB=F1NLV4	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00011	Blood coagulation	P00458	GP IIIa	CANLF|Ensembl=ENSCAFG00000013735|UniProtKB=F1PPG5	Integrin beta	ISS	7949057	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CAEEL|WormBase=WBGene00000065|UniProtKB=P0DM42	Actin-3	ISS	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P05913	Enkephalin release	P05972	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00005	Angiogenesis	P00193	SOS-1	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=2685045|UniProtKB=E9QAN8	Protein Pik3c2b	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P04398	p53 pathway feedback loops 2	P04665	AKT	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	20855874	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01435	SWI/SNF	PANTR|Ensembl=ENSPTRG00000001220|UniProtKB=H2R494	Chromodomain helicase DNA binding protein 1-like	ISS	11532957	PubMed	PTHR10799:SF949	CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1-LIKE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00029	Huntington disease	P00805	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05756	GABA-B receptor	HUMAN|HGNC=4070|UniProtKB=Q9UBS5	Gamma-aminobutyric acid type B receptor subunit 1	IDA	9872315	PubMed	PTHR10519:SF42	GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 1
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	BOVIN|Ensembl=ENSBTAG00000008059|UniProtKB=P41984	Muscarinic acetylcholine receptor M3	TAS	10069496	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00059	p53 pathway	G01579	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	MACMU|Ensembl=ENSMMUG00000022872|UniProtKB=F6WMJ4	Low-density lipoprotein receptor-related protein 3	ISS	11907044	PubMed	PTHR44062:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 3
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=19218|UniProtKB=Q86YW0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1	ISS	12860966	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04393	Ras Pathway	P04542	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IDA	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Ensembl=ENSPTRG00000018449|UniProtKB=H2QTG5	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02746	Heme biosynthesis	P02981	Glutamate-1-semialdehyde aminotransferase	SYNY3|EnsemblGenome=BAA10185|UniProtKB=Q55665	Glutamate-1-semialdehyde 2,1-aminomutase	ISS			PTHR43713:SF2	GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE 1, CHLOROPLASTIC-RELATED
P02787	Vitamin B6 metabolism	P03236	Pyridoxamine phosphate oxidase	BOVIN|Ensembl=ENSBTAG00000012259|UniProtKB=Q5E9K3	Pyridoxine-5'-phosphate oxidase	ISS	14697241	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00010	B cell activation	P00379	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05913	Enkephalin release	P05977	G-Protein (s)	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00010	B cell activation	P00373	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04398	p53 pathway feedback loops 2	P04651	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00029	Huntington disease	P00807	Actin	DICDI|dictyBase=DDB_G0268744|UniProtKB=Q55EU6	Putative actin-23	IDA	10974003	PubMed	PTHR11937:SF154	ACTIN-17-RELATED
P00005	Angiogenesis	P00243	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04395	Vasopressin synthesis	P04597	Signal Peptide	TAKRU|Ensembl=ENSTRUG00000015413|UniProtKB=H2UR30	Uncharacterized protein	ISS	6717565	PubMed	PTHR11681:SF13	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00189	Fzd	HUMAN|HGNC=4040|UniProtKB=Q14332	Frizzled-2	ISS	11212302	PubMed	PTHR11309:SF34	FRIZZLED-2
P00018	EGF receptor signaling pathway	P00554	Shc	RAT|RGD=69348|UniProtKB=O70143	SHC-transforming protein 3	ISS	96404502	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00046	Oxidative stress response	P01131	MKP5	RAT|RGD=1310844|UniProtKB=D3ZBG7	Dual specificity phosphatase 10 (Predicted)	ISS	10597297	PubMed	PTHR10159:SF299	DUAL SPECIFICITY PROTEIN PHOSPHATASE 10
P00057	Wnt signaling pathway	P01451	Galpha	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00029	Huntington disease	P00793	Arfaptin-2	BOVIN|Ensembl=ENSBTAG00000003566|UniProtKB=Q3ZCL5	Arfaptin-2	ISS	11854752	PubMed	PTHR12141:SF3	ARFAPTIN-2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	HALSA|EnsemblGenome=VNG_2383G|UniProtKB=Q9HMU4	Ribonucleoside reductase small chain	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	TAS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	XENTR|Xenbase=XB-GENE-868520|UniProtKB=K9J7V0	Uncharacterized protein	ISS	12888804	PubMed	PTHR43940:SF7	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT GAMMA
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	ORYSJ|EnsemblGenome=OS07G0694000|UniProtKB=Q6Z3Y9	Phosphoinositide phospholipase C	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00010	B cell activation	P00398	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P02723	Adenine and hypoxanthine salvage pathway	P02813	Inosine phosphorylase	MYCTU|EnsemblGenome=Rv3307|UniProtKB=P9WP01	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00053	T cell activation	P01332	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01151	PKB	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01134	cPLA2	MACMU|Ensembl=ENSMMUG00000003842|UniProtKB=F7HAF3	Phospholipase A2	ISS	1709551	gi	PTHR10728:SF32	CYTOSOLIC PHOSPHOLIPASE A2 BETA
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	CAEEL|WormBase=WBGene00000897|UniProtKB=P20792	Cell surface receptor daf-1	TAS	9395284	PubMed	PTHR23255:SF95	CELL SURFACE RECEPTOR DAF-1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00995	c-Myc	CANLF|Gene=MYC|UniProtKB=Q28350	Myc proto-oncogene protein	ISS	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	RAT|RGD=3569|UniProtKB=P49801	Regulator of G-protein signaling 6 (Fragment)	ISS	8756726	PubMed	PTHR10845:SF27	REGULATOR OF G-PROTEIN SIGNALING 6
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	XENTR|Xenbase=XB-GENE-854877|UniProtKB=F7C949	Presenilin	ISS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00005	Angiogenesis	P00203	Erk	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01208	Hsp70	RAT|RGD=620664|UniProtKB=P14659	Heat shock-related 70 kDa protein 2	IDA	12150907	PubMed	PTHR19375:SF216	HEAT SHOCK-RELATED 70 KDA PROTEIN 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00053	T cell activation	P01322	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PHYPA|Gene=PHYPADRAFT_198730|UniProtKB=Q6TYS2	Actin 1	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00048	PI3 kinase pathway	P01188	Gbetagamma	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04373	5HT1 type receptor mediated signaling pathway	P04407	K+ channel	MOUSE|MGI=MGI=1100509|UniProtKB=O35111	Potassium channel subfamily K member 3	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	RAT|RGD=2732|UniProtKB=P22756	Glutamate receptor ionotropic, kainate 1	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00005	Angiogenesis	P00253	Axin	MOUSE|MGI=MGI=1096327|UniProtKB=O35625	Axin-1	ISS	9554852	PubMed	PTHR10845:SF11	AXIN-1
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00036	Interleukin signaling pathway	P00964	p90RSK	ORNAN|Ensembl=ENSOANG00000010658|UniProtKB=F6V2V1	Uncharacterized protein	ISS	6755374	gi	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CANLF|Gene=DRD2|UniProtKB=Q9GJU1	D(2) dopamine receptor	IDA	11248120	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MACMU|Ensembl=ENSMMUG00000017358|UniProtKB=F7H957	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF22	BONE MORPHOGENETIC PROTEIN 15
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00036	Interleukin signaling pathway	P00990	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	YEAST|SGD=S000001496|UniProtKB=P33204	Actin-related protein 2/3 complex subunit 4	ISS	5031595	gi	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P02783	Tryptophan biosynthesis	P03209	Anthranilate phosphoribosyl transferase	STRCO|Gene=CAB45218|UniProtKB=Q9XA13	Putative glutamine amidotransferase	ISS			PTHR43418:SF4	MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN
P00049	Parkinson disease	P01211	ERK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	92020947	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02746	Heme biosynthesis	P02981	Glutamate-1-semialdehyde aminotransferase	CHLTR|EnsemblGenome=CT_210|UniProtKB=O84212	Glutamate-1-semialdehyde 2,1-aminomutase	ISS			PTHR43713:SF3	GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	RAT|RGD=3381|UniProtKB=P62716	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02752	Mannose metabolism	P03015	GDP-Mannose 4,6-dehydratase	PANTR|Ensembl=ENSPTRG00000017663|UniProtKB=H2QS74	Uncharacterized protein	ISS	9603974	PubMed	PTHR43715:SF1	GDP-MANNOSE 4,6 DEHYDRATASE
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	HUMAN|HGNC=19663|UniProtKB=Q9UBI6	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00035	Interferon-gamma signaling pathway	P00956	SOCS	HUMAN|HGNC=16833|UniProtKB=O14544	Suppressor of cytokine signaling 6	TAS	12645661	PubMed	PTHR44562:SF1	SUPPRESSOR OF CYTOKINE SIGNALING 6
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	CANLF|Ensembl=ENSCAFG00000000415|UniProtKB=E2R2K4	Uncharacterized protein	ISS	1904317	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00049	Parkinson disease	P01242	Casein kinase I	MOUSE|MGI=MGI=1355272|UniProtKB=Q9DC28	Casein kinase I isoform delta	IDA	11437445	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	IC	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00570	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00790	beta-Tubulin	CANLF|Ensembl=ENSCAFG00000018634|UniProtKB=E2RFV2	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF253	TUBULIN BETA-4A CHAIN
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	21157398	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	TAS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P02763	Peptidoglycan biosynthesis	P03088	UDP-N-acetylmuramate dehydrogenase	GLOVI|EnsemblGenome=BAC90258|UniProtKB=Q7NI66	UDP-N-acetylenolpyruvoylglucosamine reductase	ISS			PTHR21071:SF4	UDP-N-ACETYLENOLPYRUVOYLGLUCOSAMINE REDUCTASE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00039	Metabotropic glutamate receptor group III pathway	P01043	AC	MOUSE|MGI=MGI=2660854|UniProtKB=Q8C0T9	Adenylate cyclase type 10	IC	9874775	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P00048	PI3 kinase pathway	P01176	JAK	MOUSE|MGI=MGI=96629|UniProtKB=Q62120	Tyrosine-protein kinase JAK2	IDA	22482294	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P04397	p53 pathway by glucose deprivation	P04639	AMPK	MACMU|Ensembl=ENSMMUG00000019860|UniProtKB=F7GTI4	5'-AMP-activated protein kinase subunit beta-1	ISS			PTHR10343:SF16	5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1
P00047	PDGF signaling pathway	P01142	p90RSK	MACMU|Ensembl=ENSMMUG00000022111|UniProtKB=F7H7W3	Ribosomal protein S6 kinase	ISS	2779569	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00029	Huntington disease	P00780	Microtubule	EMENI|EnsemblGenome=CADANIAG00001443|UniProtKB=P10653	Tubulin beta-1 chain	IDA	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00056	VEGF signaling pathway	P01411	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00060	Ubiquitin proteasome pathway	P01491	E2	BATDJ|Gene=BATDEDRAFT_14888|UniProtKB=F4PEG9	Putative uncharacterized protein	ISS			PTHR24068:SF74	FI16911P1-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CAEBR|Gene=CBG18715|UniProtKB=A8XTZ1	Phosphoinositide phospholipase C	ISS			PTHR10336:SF91	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	MOUSE|MGI=MGI=1339946|UniProtKB=P62340	TATA box-binding protein-like protein 1	ISS	10082669	PubMed	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	XENTR|Xenbase=XB-GENE-487200|UniProtKB=Q28GC2	Catenin (Cadherin associated protein), beta 1, 88kDa	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P00012	Cadherin signaling pathway	P00466	EGFR	PANTR|Ensembl=ENSPTRG00000012883|UniProtKB=H2QJC5	Receptor protein-tyrosine kinase	ISS	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00049	Parkinson disease	P01219	SAPK	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	NAS	10514528	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00037	Ionotropic glutamate receptor pathway	P01026	KA	BOVIN|Ensembl=ENSBTAG00000034854|UniProtKB=F1N246	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00018	EGF receptor signaling pathway	P00565	PKC	CANAL|CGD=CAL0003231|UniProtKB=Q5ANK2	Protein kinase C	IGI	8813761	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00052	TGF-beta signaling pathway	P01284	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	IC	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05734	Synaptic vesicle trafficking	P05779	Synaptobrevin	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	RCA	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00029	Huntington disease	P00790	beta-Tubulin	THAPS|Gene=Thaps8069|UniProtKB=B8C8B4	Tubulin beta	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00009	Axon guidance mediated by netrin	P00357	Netrin	MACMU|Ensembl=ENSMMUG00000006923|UniProtKB=F7EUX0	Uncharacterized protein	ISS			PTHR10574:SF27	NETRIN-G2
P00006	Apoptosis signaling pathway	P00269	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	8946911	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00023	General transcription regulation	P00658	TBP-associated factors	XENTR|Xenbase=XB-GENE-943294|UniProtKB=B0BLT7	Uncharacterized protein	ISS			PTHR12264:SF21	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12
P00034	Integrin signalling pathway	P00907	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01219	SAPK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	NAS	10851062	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	PANTR|Ensembl=ENSPTRG00000014848|UniProtKB=P56440	C-C chemokine receptor type 5	ISS			PTHR10489:SF686	C-C CHEMOKINE RECEPTOR TYPE 5
P00047	PDGF signaling pathway	P01162	MEK	CAEBR|Gene=CBG04190|UniProtKB=A8WWD7	Protein CBR-MEK-2	ISS	22022015	PubMed	PTHR24361:SF629	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00313	IKK	BOVIN|Ensembl=ENSBTAG00000007599|UniProtKB=Q95KV0	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	MACMU|Ensembl=ENSMMUG00000010392|UniProtKB=F7ASR8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00047	PDGF signaling pathway	P01153	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00059	p53 pathway	P04609	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	12660731	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	SCHPO|PomBase=SPAC458.05|UniProtKB=P50520	Phosphatidylinositol 3-kinase vps34	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	RCA	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	RAT|RGD=2743|UniProtKB=P31421	Metabotropic glutamate receptor 2	ISS	12351712	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00055	Transcription regulation by bZIP transcription factor	P01390	TFIIA complex	RAT|RGD=69246|UniProtKB=O08949	Transcription initiation factor IIA subunit 1	ISS	600519	OMIM	PTHR12694:SF7	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00029	Huntington disease	P00807	Actin	PLAF7|EnsemblGenome=PFL2215w|UniProtKB=Q8I4X0	Actin-1	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P02738	De novo purine biosynthesis	P02909	GDP reductase	PSEAE|EnsemblGenome=PA1156|UniProtKB=Q9I4I1	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	METAC|EnsemblGenome=MA_1096|UniProtKB=Q8TRS3	Adenylate kinase	ISS			PTHR23359:SF22	GTP:AMP PHOSPHOTRANSFERASE, MITOCHONDRIAL
P00034	Integrin signalling pathway	P00941	Integrin alpha	MACMU|Ensembl=ENSMMUG00000001753|UniProtKB=F7GLR9	Uncharacterized protein	ISS	3487386	PubMed	PTHR23220:SF22	INTEGRIN ALPHA-1
P05913	Enkephalin release	P05972	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00010	B cell activation	P00381	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IGI	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01438	PP2A	CANLF|Ensembl=ENSCAFG00000001753|UniProtKB=F1P714	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2521|UniProtKB=P19020	D(3) dopamine receptor	IDA	11861492	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00037	Ionotropic glutamate receptor pathway	P01026	KA	BOVIN|Ensembl=ENSBTAG00000009269|UniProtKB=F1MCM2	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00047	PDGF signaling pathway	P01154	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00049	Parkinson disease	P01236	Casein kinase II	BOVIN|Ensembl=ENSBTAG00000008837|UniProtKB=P67868	Casein kinase II subunit beta	IDA	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00052	TGF-beta signaling pathway	P01287	BAMBI	MOUSE|MGI=MGI=1915260|UniProtKB=Q9D0L6	BMP and activin membrane-bound inhibitor homolog	ISS	10519551	PubMed	PTHR15505:SF1	BMP AND ACTIVIN MEMBRANE-BOUND INHIBITOR HOMOLOG
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00053	T cell activation	P01332	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00557	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00053	T cell activation	P01322	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01199	Galpha	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	IC	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00547	PP2A	BOVIN|Ensembl=ENSBTAG00000000469|UniProtKB=P67774	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	EMENI|EnsemblGenome=CADANIAG00007315|UniProtKB=P20359	Actin, gamma	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02770	Pyridoxal phosphate salvage pathway	P03123	Pyridoxine-5-phosphate oxidase	MACMU|Ensembl=ENSMMUG00000003325|UniProtKB=F7EHD9	Pyridoxine-5'-phosphate oxidase	ISS	14697241	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00036	Interleukin signaling pathway	P00990	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00057	Wnt signaling pathway	P01443	Phospholipase C	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IDA	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P05915	Opioid proenkephalin pathway	P05988	peptide E	RAT|RGD=68946|UniProtKB=P04094	Proenkephalin-A	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00047	PDGF signaling pathway	P01171	PLCgamma	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P02762	Pentose phosphate pathway	P03080	Glucose-P-Isomerase	HUMAN|HGNC=4458|UniProtKB=P06744	Glucose-6-phosphate isomerase	ISS	2248981	PubMed	PTHR11469:SF4	GLUCOSE-6-PHOSPHATE ISOMERASE
P00047	PDGF signaling pathway	P01160	IP3 receptor	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00004	Alzheimer disease-presenilin pathway	P00113	Erb-B4 transmembrane fragment	RAT|RGD=620486|UniProtKB=Q62956	Receptor tyrosine-protein kinase erbB-4	IDA	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	MOUSE|MGI=MGI=1351344|UniProtKB=Q68ED2	Metabotropic glutamate receptor 7	ISS	9407094	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	ARATH|TAIR=AT1G30820|UniProtKB=F4I6G9	CTP synthase	ISS			PTHR11550:SF23	CTP SYNTHASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P05913	Enkephalin release	P05977	G-Protein (s)	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	RAT|RGD=61863|UniProtKB=P19493	Glutamate receptor 4	ISS	12941441	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	LEIMA|EnsemblGenome=LmjF.35.4010|UniProtKB=Q9GNR4	Protein kinase A catalytic subunit isoform 1	IC	10218114	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P02748	Isoleucine biosynthesis	P02998	Dihydroxyacid dehydratase	SCHPO|PomBase=SPAC17G8.06c|UniProtKB=Q10318	Putative dihydroxy-acid dehydratase, mitochondrial	ISS			PTHR21000:SF5	DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P06959	CCKR signaling map	P07086	PLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	RCA	10080535	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00029	Huntington disease	P00808	Caspase 8	HUMAN|HGNC=1509|UniProtKB=Q14790	Caspase-8	IDA	11788820	PubMed	PTHR10454:SF162	CASPASE-8
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IGI	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04393	Ras Pathway	P04578	Rho	TAKRU|Ensembl=ENSTRUG00000010405|UniProtKB=H2TNE6	Uncharacterized protein (Fragment)	ISS			PTHR24072:SF260	RHO-RELATED GTP-BINDING PROTEIN RHOA-A-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MONDO|Ensembl=ENSMODG00000001303|UniProtKB=F7BZM9	Uncharacterized protein (Fragment)	ISS	12963527	gi	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00057	Wnt signaling pathway	P01455	Smad4	TAKRU|Ensembl=ENSTRUG00000014344|UniProtKB=H2UI95	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00029	Huntington disease	P00775	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	15470041	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00021	FGF signaling pathway	P00638	PLCgamma	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00014	Cholesterol biosynthesis	P00492	Mevalonate kinase	PANTR|Ensembl=ENSPTRG00000005428|UniProtKB=H2Q6U7	Mevalonate kinase	ISS	4557769	gi	PTHR43290:SF2	MEVALONATE KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04585	TRH	DANRE|ZFIN=ZDB-GENE-030513-3|UniProtKB=B3DJU0	Thyroid stimulating hormone, beta subunit	ISS			PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000008751|UniProtKB=H2QC89	Uncharacterized protein	ISS	12507995	PubMed	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00010	B cell activation	P00402	Jnk	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00034	Integrin signalling pathway	P00920	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00054	Toll receptor signaling pathway	P01367	MKK3	CHICK|Ensembl=ENSGALG00000004735|UniProtKB=F1NHE1	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00006	Apoptosis signaling pathway	P00310	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00542	EGFR	ORNAN|Ensembl=ENSOANG00000007021|UniProtKB=F7GAV2	Receptor protein-tyrosine kinase	ISS	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00030	Hypoxia response via HIF activation	P00819	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00566	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CAEEL|WormBase=WBGene00006932|UniProtKB=Q9TXI7	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	21924698	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=620023|UniProtKB=P10980	Muscarinic acetylcholine receptor M2	IDA	12181435	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ORNAN|Ensembl=ENSOANG00000007581|UniProtKB=F6QWB7	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00029	Huntington disease	P00780	Microtubule	STRPU|EnsemblGenome=SPU_007425|UniProtKB=W4XVG9	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00009	Axon guidance mediated by netrin	P00356	UNC-5	CANLF|Ensembl=ENSCAFG00000014319|UniProtKB=E2RC29	Uncharacterized protein	ISS			PTHR12582:SF6	NETRIN RECEPTOR UNC5B
P00029	Huntington disease	P00779	TBP	CHICK|Gene=TBP|UniProtKB=O13270	TATA-box-binding protein	IPI	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00023	General transcription regulation	P00659	TFIIEbeta	ANOGA|EnsemblGenome=AGAP005382|UniProtKB=Q7Q7C7	Transcription initiation factor IIE subunit beta	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	TAS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	HUMAN|HGNC=6843|UniProtKB=P46734	Dual specificity mitogen-activated protein kinase kinase 3	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	ANOGA|Gene=AgaP_AGAP009115|UniProtKB=Q7PW25	Phosphoinositide phospholipase C (Fragment)	ISS	12176394	PubMed	PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00048	PI3 kinase pathway	P01177	P110ACT	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00646	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	IPI	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00633	Ras	MONDO|Gene=KRAS|UniProtKB=Q07983	GTPase KRas	ISS	3023884	PubMed	PTHR24070:SF186	GTPASE KRAS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02783	Tryptophan biosynthesis	P03211	Phosphribosyl anthranilate isomerase	YEAST|SGD=S000002414|UniProtKB=P00912	N-(5'-phosphoribosyl)anthranilate isomerase	ISS			PTHR42894:SF1	N- 5'-PHOSPHORIBOSYL ANTHRANILATE ISOMERASE
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	DANRE|ZFIN=ZDB-GENE-051202-1|UniProtKB=E7F101	Uncharacterized protein	ISS	14698601	PubMed	PTHR44391:SF2	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00057	Wnt signaling pathway	P01440	Cadherin	ORNAN|Ensembl=ENSOANG00000002500|UniProtKB=F6VEV5	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF96	CADHERIN-12
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	HUMAN|HGNC=4411|UniProtKB=P63211	Guanine nucleotide-binding protein G(T) subunit gamma-T1	IDA	3100519	PubMed	PTHR13809:SF26	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT GAMMA-T1
P00005	Angiogenesis	P00236	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00254	GTPase	PANTR|Ensembl=ENSPTRG00000001112|UniProtKB=H2PZP2	Ras homolog gene family, member C	ISS	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MACMU|Ensembl=ENSMMUG00000032222|UniProtKB=F7FW05	Uncharacterized protein	ISS			PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00009	Axon guidance mediated by netrin	P00357	Netrin	BOVIN|Ensembl=ENSBTAG00000012137|UniProtKB=F1N0C7	Uncharacterized protein	ISS	9427245	PubMed	PTHR10574:SF365	NETRIN-1
P00030	Hypoxia response via HIF activation	P00814	P300	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IDA	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	MOUSE|MGI=MGI=1929612|UniProtKB=Q9R0T8	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	IDA	11238099	PubMed	PTHR22969:SF10	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT EPSILON
P00005	Angiogenesis	P00190	RasGAP	HUMAN|HGNC=9871|UniProtKB=P20936	Ras GTPase-activating protein 1	IDA	11847220	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00055	Transcription regulation by bZIP transcription factor	P01395	TFIIE	CANLF|Ensembl=ENSCAFG00000006489|UniProtKB=E2R5J2	Transcription initiation factor IIE subunit beta	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00561	STAT	CANLF|Ensembl=ENSCAFG00000015509|UniProtKB=F1PNW8	Signal transducer and activator of transcription	ISS	96210005	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=1351339|UniProtKB=Q14BI2	Metabotropic glutamate receptor 2	ISS	20012997	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P02785	Valine biosynthesis	P03216	Acetolactate synthase	SULSO|EnsemblGenome=SSO3210|UniProtKB=Q97U16	Acetolactate synthase large subunit homolog (IlvB-6)	ISS			PTHR18968:SF135	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01177	P110ACT	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00796	Kainate receptor	MACMU|Ensembl=ENSMMUG00000004886|UniProtKB=F7AGT9	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P02741	Flavin biosynthesis	P02933	Pyrimidine deaminase	BACSU|EnsemblGenome=BSU23280|UniProtKB=P17618	Riboflavin biosynthesis protein RibD	ISS			PTHR44288:SF1	RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBD
P00021	FGF signaling pathway	P00632	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-2280|UniProtKB=Q6P025	Gnb3 protein	ISS			PTHR19850:SF35	GNB3 PROTEIN
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	ORNAN|Ensembl=ENSOANG00000015652|UniProtKB=F7FY70	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00018	EGF receptor signaling pathway	P00552	Ras	YEAST|SGD=S000005627|UniProtKB=P01119	Ras-like protein 1	ISS	7997267	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00736	CalDAG-GEF	MACMU|Ensembl=ENSMMUG00000022598|UniProtKB=F6Z7B1	Uncharacterized protein	ISS	10835426	PubMed	PTHR23113:SF16	RAS GUANYL-RELEASING PROTEIN 2
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00057	Wnt signaling pathway	P01444	Wnt	CAEBR|Gene=CBG03476|UniProtKB=A8WV58	Protein CBR-EGL-20	ISS	8717036	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P00021	FGF signaling pathway	P00629	PP2A	ARATH|TAIR=AT3G09880|UniProtKB=O04376	Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' beta isoform	ISS			PTHR10257:SF3	PP2A-B', ISOFORM B
P00049	Parkinson disease	P01227	20S proteasome	HUMAN|HGNC=9538|UniProtKB=P40306	Proteasome subunit beta type-10	TAS	12859888	PubMed	PTHR11599:SF41	PROTEASOME SUBUNIT BETA TYPE-10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Gene=HTR2C|UniProtKB=Q5IS66	5-hydroxytryptamine receptor 2C	ISS			PTHR24247:SF32	5-HYDROXYTRYPTAMINE RECEPTOR 2C
P00048	PI3 kinase pathway	P01179	PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	G04694	p110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05755	Gbeta	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00005	Angiogenesis	P00206	Wnt	RAT|RGD=1307015|UniProtKB=D3ZRW5	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00004	Alzheimer disease-presenilin pathway	P00117	E-cadherin C-terminal fragment	MOUSE|MGI=MGI=88354|UniProtKB=P09803	Cadherin-1	IDA	8120095	PubMed	PTHR24027:SF319	CADHERIN-1
P00010	B cell activation	P00385	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00036	Interleukin signaling pathway	P00972	MNK1/2	MACMU|Ensembl=ENSMMUG00000020162|UniProtKB=F6TJV6	Uncharacterized protein	ISS	Q9BUB5	SPACC	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04393	Ras Pathway	P04569	Cdc42	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g189251|UniProtKB=A7SFJ1	Predicted protein	ISS	15723050	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04393	Ras Pathway	P04563	Ets	ORNAN|Ensembl=ENSOANG00000012104|UniProtKB=F7FH70	Uncharacterized protein	ISS	3284179	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	MONDO|Ensembl=ENSMODG00000015869|UniProtKB=F7F073	Uncharacterized protein	ISS			PTHR24073:SF269	DNAJ HOMOLOG SUBFAMILY C MEMBER 27
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	18021322	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00057	Wnt signaling pathway	P01451	Galpha	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00005	Angiogenesis	P00226	Delta/Serrate	DANRE|ZFIN=ZDB-GENE-980526-29|UniProtKB=Q6DI48	Delta-like protein A	ISS			PTHR24044:SF409	DELTA-LIKE PROTEIN A
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-050417-59|UniProtKB=Q15KE4	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04371	5-Hydroxytryptamine biosynthesis	P04399	Tryptophan hydroxylase	HUMAN|HGNC=12008|UniProtKB=P17752	Tryptophan 5-hydroxylase 1	ISS	14597720	PubMed	PTHR11473:SF23	TRYPTOPHAN 5-HYDROXYLASE 1
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00518	Rho GEFs	RAT|RGD=620951|UniProtKB=Q9Z1I6	Rho guanine nucleotide exchange factor 1	ISS	12024019	PubMed	PTHR12673:SF122	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 1
P00009	Axon guidance mediated by netrin	P00364	cdc42	DROME|FlyBase=FBgn0010341|UniProtKB=P40793	Cdc42 homolog	ISS	4757952	gi	PTHR24072:SF192	CDC42 HOMOLOG
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	YEAST|SGD=S000001324|UniProtKB=P40518	Actin-related protein 2/3 complex subunit 5	ISS			PTHR12644:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01185	SOS	CHICK|Ensembl=ENSGALG00000013224|UniProtKB=F1NMA4	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Gene=SSTR2|UniProtKB=P34993	Somatostatin receptor type 2	ISS	12441358	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00047	PDGF signaling pathway	P01154	Ras	CHICK|Ensembl=ENSGALG00000014033|UniProtKB=E1BTS2	Uncharacterized protein	ISS	9869449	PubMed	PTHR24070:SF186	GTPASE KRAS
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	XENTR|Xenbase=XB-GENE-1012455|UniProtKB=F6TKH3	Uncharacterized protein (Fragment)	ISS			PTHR11824:SF7	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	HUMAN|HGNC=130|UniProtKB=P62736	Actin, aortic smooth muscle	IEP	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_56687|UniProtKB=C3YC50	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00924	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	3449797	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00006	Apoptosis signaling pathway	P00302	ATF	RAT|RGD=621611|UniProtKB=Q78E65	Jun dimerization protein 2	ISS			PTHR23351:SF10	JUN DIMERIZATION PROTEIN 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	IC	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00019	Endothelin signaling pathway	P00591	PLCbeta	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00005	Angiogenesis	P00223	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04556	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P06959	CCKR signaling map	P07094	EIF4E	HUMAN|HGNC=3287|UniProtKB=P06730	Eukaryotic translation initiation factor 4E	RCA	9619831	PubMed	PTHR11960:SF14	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E
P00047	PDGF signaling pathway	P01159	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P04611	P300	MOUSE|MGI=MGI=1276116|UniProtKB=B2RWS6	Histone acetyltransferase p300	ISS	10769018	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00054	Toll receptor signaling pathway	P01347	MD-2	PANTR|Ensembl=ENSPTRG00000020351|UniProtKB=B3Y6A6	Lymphocyte antigen 96	ISS			PTHR15218:SF0	LYMPHOCYTE ANTIGEN 96
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	PLAF7|EnsemblGenome=PF14_0164|UniProtKB=Q8ILT0	Glutamate dehydrogenase	ISS			PTHR43571:SF1	NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED
P04393	Ras Pathway	P04547	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P02734	Chorismate biosynthesis	P02872	3-Dehydroquinate synthase	ARATH|TAIR=AT5G66120|UniProtKB=Q8VYV7	3-dehydroquinate synthase, chloroplastic	ISS			PTHR43622:SF4	3-DEHYDROQUINATE SYNTHASE, CHLOROPLASTIC
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P06664	Gonadotropin-releasing hormone receptor pathway	P06807	gnai	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	RCA	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00561	STAT	CANLF|Ensembl=ENSCAFG00000015509|UniProtKB=F1PNW8	Signal transducer and activator of transcription	ISS	22320921	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00006	Apoptosis signaling pathway	P00310	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00013	Cell cycle	P00480	Proteasome	NEUCR|EnsemblGenome=EFNCRG00000001793|UniProtKB=Q1K564	26S proteasome non-ATPase regulatory subunit 11	NAS	11280491	gi	PTHR10678:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00047	PDGF signaling pathway	P01161	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	SCHPO|PomBase=SPAC458.05|UniProtKB=P50520	Phosphatidylinositol 3-kinase vps34	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01443	Phospholipase C	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IDA	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00009	Axon guidance mediated by netrin	P00356	UNC-5	BOVIN|Ensembl=ENSBTAG00000014897|UniProtKB=F1MQ73	Uncharacterized protein	ISS			PTHR12582:SF4	NETRIN RECEPTOR UNC5A
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	RAT|RGD=620761|UniProtKB=Q9R172	Neurogenic locus notch homolog protein 3	IDA	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	CAEEL|WormBase=WBGene00001679|UniProtKB=P17343	Guanine nucleotide-binding protein subunit beta-1	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00021	FGF signaling pathway	P00634	MEKK1-5	CANLF|Ensembl=ENSCAFG00000000760|UniProtKB=E2R9L4	Uncharacterized protein	ISS	602425	OMIM	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00059	p53 pathway	G01574	ARF	PANTR|Ensembl=ENSPTRG00000010477|UniProtKB=H2QFC1	Uncharacterized protein	ISS			PTHR24148:SF47	CYCLIN-DEPENDENT KINASE 4 INHIBITOR B-RELATED
P00019	Endothelin signaling pathway	P00580	ET-RA/B	RAT|RGD=2535|UniProtKB=P26684	Endothelin-1 receptor	IGI	91195317	PubMed	PTHR24243:SF31	ENDOTHELIN-1 RECEPTOR
P00025	Hedgehog signaling pathway	P00682	PKA	NEUCR|EnsemblGenome=EFNCRG00000004240|UniProtKB=Q01386	cAMP-dependent protein kinase regulatory subunit	ISS	2372396	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00916	Ras	CHICK|Ensembl=ENSGALG00000006885|UniProtKB=P08642	GTPase HRas	ISS	3035212	PubMed	PTHR24070:SF385	GTPASE HRAS
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05938	RhoA	XENTR|Xenbase=XB-GENE-489222|UniProtKB=Q28GJ8	Ras homolog gene family, member A	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	MOUSE|MGI=MGI=104589|UniProtKB=P63268	Actin, gamma-enteric smooth muscle	IC	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00029	Huntington disease	P00811	Arp2/3 complex	PANTR|Ensembl=ENSPTRG00000001767|UniProtKB=G2HG81	Actin-related protein 2/3 complex subunit 5	ISS	12473693	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00050	Plasminogen activating cascade	P01252	MMP-1	MACMU|Ensembl=ENSMMUG00000002037|UniProtKB=F6WYF2	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF151	INTERSTITIAL COLLAGENASE
P00003	Alzheimer disease-amyloid secretase pathway	P00084	X11alpha	MOUSE|MGI=MGI=1860297|UniProtKB=B2RUJ5	Amyloid beta A4 precursor protein-binding family A member 1	ISS	9614075	PubMed	PTHR12345:SF14	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 1
P00054	Toll receptor signaling pathway	P01375	JNK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00010	B cell activation	P00398	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00049	Parkinson disease	P01208	Hsp70	MONDO|Ensembl=ENSMODG00000012827|UniProtKB=F7DD51	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF239	HEAT SHOCK COGNATE 71 KDA PROTEIN
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MOUSE|MGI=MGI=103077|UniProtKB=Q64704	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	BOVIN|Ensembl=ENSBTAG00000047202|UniProtKB=G3N3K3	Uncharacterized protein	ISS	11554554	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00018	EGF receptor signaling pathway	P00551	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IGI	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00546	GAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	8270251	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01367	MKK3	MONDO|Ensembl=ENSMODG00000001404|UniProtKB=F7BD74	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	CHLTR|EnsemblGenome=CT_500|UniProtKB=O84508	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MACMU|Ensembl=ENSMMUG00000021796|UniProtKB=F7ET64	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF74	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	LEIMA|EnsemblGenome=LmjF.04.1230|UniProtKB=Q9U1E8	Actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P05918	p38 MAPK pathway	P05921	MKP5	MOUSE|MGI=MGI=1927070|UniProtKB=Q9ESS0	Dual specificity protein phosphatase 10	RCA	11856337	PubMed	PTHR10159:SF299	DUAL SPECIFICITY PROTEIN PHOSPHATASE 10
P00030	Hypoxia response via HIF activation	P00824	PTEN	DROME|FlyBase=FBgn0026379|UniProtKB=Q7KMQ6	IP16020p	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00036	Interleukin signaling pathway	P00973	PKB	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00052	TGF-beta signaling pathway	P01287	BAMBI	XENTR|Xenbase=XB-GENE-495359|UniProtKB=Q6F2E0	BMP and activin membrane-bound inhibitor homolog	ISS	10519551	PubMed	PTHR15505:SF1	BMP AND ACTIVIN MEMBRANE-BOUND INHIBITOR HOMOLOG
P05916	Opioid prodynorphin pathway	P06002	G-protein	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00011	Blood coagulation	P00421	alpha1-antitrypsin	MACMU|Ensembl=ENSMMUG00000020426|UniProtKB=F6SEN6	Alpha-1-antitrypsin	ISS	1942629	gi	PTHR11461:SF165	ALPHA-1-ANTITRYPSIN-RELATED
P00010	B cell activation	P00385	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	SCHPO|PomBase=SPBC32H8.07|UniProtKB=Q10282	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00053	T cell activation	P01306	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IDA	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00010	B cell activation	P00376	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P00005	Angiogenesis	P00219	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	RCA	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04393	Ras Pathway	P04547	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONBE|Gene=37852|UniProtKB=A9V489	Predicted protein	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06959	CCKR signaling map	P07214	RAC1-GTP	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	RCA	19940064	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00029	Huntington disease	P00775	Rac	RAT|RGD=621310|UniProtKB=Q32PX6	Protein Rhog	ISS	4757952	gi	PTHR24072:SF158	RHO-RELATED GTP-BINDING PROTEIN RHOG
P00053	T cell activation	P01336	Jnk	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00034	Integrin signalling pathway	P00936	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	ANOGA|EnsemblGenome=AGAP010278|UniProtKB=Q7Q0L5	AGAP010278-PA	ISS			PTHR22778:SF16	DIHYDROFOLATE REDUCTASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00012	Cadherin signaling pathway	P00465	TCF/LEF	HUMAN|HGNC=11641|UniProtKB=Q9NQB0	Transcription factor 7-like 2	ISS	12356903	PubMed	PTHR10373:SF32	TRANSCRIPTION FACTOR 7-LIKE 2
P00005	Angiogenesis	P00243	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	ARATH|TAIR=AT3G45640|UniProtKB=Q39023	Mitogen-activated protein kinase 3	TAS			PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00012	Cadherin signaling pathway	P00475	Frizzled	HUMAN|HGNC=4039|UniProtKB=Q9ULW2	Frizzled-10	IDA	11212302	PubMed	PTHR11309:SF86	FRIZZLED-10
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	RCA	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CANLF|Ensembl=ENSCAFG00000019823|UniProtKB=E2R4I7	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	RAT|RGD=1306661|UniProtKB=G3V926	Conserved helix-loop-helix ubiquitous kinase (Predicted)	RCA			PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00048	PI3 kinase pathway	P01192	p110	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00054	Toll receptor signaling pathway	P01355	AP1	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	YARLI|EnsemblGenome=YALI0_D08272g|UniProtKB=Q9UVF3	Actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00047	PDGF signaling pathway	P01154	Ras	MONDO|Gene=KRAS|UniProtKB=Q07983	GTPase KRas	ISS	99084794	PubMed	PTHR24070:SF186	GTPASE KRAS
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00045	Notch signaling pathway	P01102	Sel 10	HUMAN|HGNC=16712|UniProtKB=Q969H0	F-box/WD repeat-containing protein 7	ISS			PTHR44007:SF6	F-BOX/WD REPEAT-CONTAINING PROTEIN 7
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	MACMU|Ensembl=ENSMMUG00000017256|UniProtKB=F7GWW5	Uncharacterized protein	ISS	18021322	PubMed	PTHR10037:SF137	VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1G
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00034	Integrin signalling pathway	P00941	Integrin alpha	MACMU|Ensembl=ENSMMUG00000021927|UniProtKB=F6T4B4	Uncharacterized protein	ISS	10209034	PubMed	PTHR23220:SF69	INTEGRIN ALPHA-9
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	HUMAN|HGNC=4598|UniProtKB=O15303	Metabotropic glutamate receptor 6	ISS	12488551	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00049	Parkinson disease	P01211	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00975	RasGAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	2842690	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04393	Ras Pathway	P04569	Cdc42	DROME|FlyBase=FBgn0010341|UniProtKB=P40793	Cdc42 homolog	ISS	4757952	gi	PTHR24072:SF192	CDC42 HOMOLOG
P05913	Enkephalin release	P05974	G-Protein (i)	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02738	De novo purine biosynthesis	P02904	Guanylate kinase	STRCO|EnsemblGenome=CAB93359|UniProtKB=Q9KXS0	Guanylate kinase	ISS			PTHR23117:SF13	GUANYLATE KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02785	Valine biosynthesis	P03217	Dihydroxy isovalerate reductoisomerase	THEMA|EnsemblGenome=TM_0550|UniProtKB=Q9WZ20	Ketol-acid reductoisomerase	ISS			PTHR21371:SF1	KETOL-ACID REDUCTOISOMERASE, CHLOROPLASTIC
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	RAT|RGD=3274|UniProtKB=P23377	Furin	IDA	11861638	PubMed	PTHR42884:SF1	FURIN
P02781	Threonine biosynthesis	P03188	Homoserine dehydrogenase	DEIRA|EnsemblGenome=DR_1278|UniProtKB=Q9RUV3	Homoserine dehydrogenase	ISS			PTHR43331:SF1	SUBFAMILY NOT NAMED
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00005	Angiogenesis	P00223	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01182	Ras	CANAL|EnsemblGenome=CaO19.1760|UniProtKB=Q59XU5	Ras-like protein 1	ISS	10515923	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P06664	Gonadotropin-releasing hormone receptor pathway	G06881	Rap1b	MOUSE|MGI=MGI=894315|UniProtKB=Q99JI6	Ras-related protein Rap-1b	RCA	10476970	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00018	EGF receptor signaling pathway	P00545	JNK1-3	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS			PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00016	Cytoskeletal regulation by Rho GTPase	P00519	ROCK	MACMU|Ensembl=ENSMMUG00000004656|UniProtKB=F6T5Y1	Uncharacterized protein	ISS	10779382	PubMed	PTHR22988:SF33	RHO-ASSOCIATED PROTEIN KINASE 1
P06959	CCKR signaling map	P07019	RHOA-GDP	HUMAN|HGNC=667|UniProtKB=P61586	Transforming protein RhoA	RCA	19074642	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00059	p53 pathway	P04619	HMG1	RAT|RGD=6491580|UniProtKB=M0R7R5	Protein LOC100911637	ISS			PTHR13711:SF164	HIGH MOBILITY GROUP PROTEIN B1-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02723	Adenine and hypoxanthine salvage pathway	P02805	Adenine phosphorylase	SCHPO|PomBase=SPAC1805.16c|UniProtKB=Q9UTG1	Putative purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PANTR|Ensembl=ENSPTRG00000008524|UniProtKB=H2QBT9	Uncharacterized protein	ISS			PTHR13140:SF255	UNCONVENTIONAL MYOSIN-IC
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	TAKRU|Ensembl=ENSTRUG00000010005|UniProtKB=H2TKG8	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00467	alpha-catenin	XENTR|Xenbase=XB-GENE-479599|UniProtKB=F7DHT4	Uncharacterized protein	ISS	9362521	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00024	Glycolysis	P00672	Phosphofructokinase-1	SYNY3|EnsemblGenome=BAA10770|UniProtKB=Q55988	ATP-dependent 6-phosphofructokinase 2	ISS	97061201	PubMed	PTHR13697:SF51	ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE 1-RELATED
P00034	Integrin signalling pathway	P00936	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05913	Enkephalin release	P05977	G-Protein (s)	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P02771	Pyrimidine Metabolism	P03129	Aminotransferase	MOUSE|MGI=MGI=2443582|UniProtKB=P61922	4-aminobutyrate aminotransferase, mitochondrial	IDA	10989446	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00048	PI3 kinase pathway	P01179	PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04559	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	10540223	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00005	Angiogenesis	P00243	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00206	Wnt	RAT|RGD=1597195|UniProtKB=D4A9J2	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00017	DNA replication	P00527	Histones	THAPS|Gene=Thaps29950|UniProtKB=B8CC53	Histone H3	ISS	12413958	PubMed	PTHR11426:SF101	HISTONE H3-LIKE CENTROMERIC PROTEIN CID
P00049	Parkinson disease	P01208	Hsp70	BRADU|EnsemblGenome=BAC45944|UniProtKB=P94317	Chaperone protein DnaK	IDA	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	MOUSE|MGI=MGI=109323|UniProtKB=Q02152	5-hydroxytryptamine receptor 2B	ISS	8143856	PubMed	PTHR24247:SF31	5-HYDROXYTRYPTAMINE RECEPTOR 2B
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	TAS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IDA	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	PANTR|Ensembl=ENSPTRG00000002007|UniProtKB=H2Q165	TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa	ISS	10894955	PubMed	PTHR32122:SF1	TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT A
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CAEEL|WormBase=WBGene00001681|UniProtKB=P54406	Guanine nucleotide-binding protein subunit gamma	IC	9754712	PubMed	PTHR13809:SF3	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA-RELATED
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PHANO|EnsemblGenome=SNOG_01139|UniProtKB=H2KNE6	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=12781|UniProtKB=Q93097	Protein Wnt-2b	TAS	8717036	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00924	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00021	FGF signaling pathway	P00629	PP2A	XENTR|Xenbase=XB-GENE-957248|UniProtKB=Q6GLE6	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05914	Nicotine degradation	P05979	FMO3	HUMAN|HGNC=3771|UniProtKB=P31513	Dimethylaniline monooxygenase [N-oxide-forming] 3	TAS	1446003	PubMed	PTHR23023:SF44	DIMETHYLANILINE MONOOXYGENASE  N-OXIDE-FORMING  3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_56698|UniProtKB=C3XYC3	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_127488|UniProtKB=C3XYC7	Putative uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00020	FAS signaling pathway	P00603	Pro-Caspase9	PANTR|Ensembl=ENSPTRG00000000200|UniProtKB=H2PY35	Caspase	ISS	11440972	PubMed	PTHR10454:SF157	CASPASE-9
P04398	p53 pathway feedback loops 2	P04661	PI3K	DROME|FlyBase=FBgn0015278|UniProtKB=Q7K3H0	LD28067p	ISS	14526383	PubMed	PTHR10048:SF64	LD28067P
P00057	Wnt signaling pathway	P01461	FrzB	RAT|RGD=621075|UniProtKB=Q9JLS4	Secreted frizzled-related protein 4	IDA	9118218	PubMed	PTHR11309:SF7	SECRETED FRIZZLED-RELATED PROTEIN 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=17175|UniProtKB=Q9P212	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	12176394	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00048	PI3 kinase pathway	P01199	Galpha	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00034	Integrin signalling pathway	P00948	Rho	PANTR|Ensembl=ENSPTRG00000014922|UniProtKB=H2QML4	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P04393	Ras Pathway	P04557	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	IDA	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	CAEBR|Gene=CBG18112|UniProtKB=A8XT20	Protein CBR-GLR-1	ISS	10331083	PubMed	PTHR18966:SF297	GLUTAMATE RECEPTOR 1
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00006	Apoptosis signaling pathway	P00269	MAPK	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	RCA	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	MONDO|Ensembl=ENSMODG00000009618|UniProtKB=F6REU0	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P06664	Gonadotropin-releasing hormone receptor pathway	P06738	PLA2	MOUSE|MGI=MGI=1196403|UniProtKB=Q08EC7	Pla2g4c protein	RCA			PTHR10728:SF39	CYTOSOLIC PHOSPHOLIPASE A2 GAMMA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MONDO|Ensembl=ENSMODG00000013970|UniProtKB=F6R6X5	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P04393	Ras Pathway	P04566	Stat 1/3	PANTR|Ensembl=ENSPTRG00000009200|UniProtKB=H2QD20	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	TAS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00572	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00021	FGF signaling pathway	P00645	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12912997	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01192	p110	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00383	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IDA	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000011761|UniProtKB=F1MDE1	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00945	Parvin	BOVIN|Ensembl=ENSBTAG00000021978|UniProtKB=F1MC75	Uncharacterized protein	ISS	11331308	PubMed	PTHR12114:SF7	BETA-PARVIN
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	PANTR|Ensembl=ENSPTRG00000002775|UniProtKB=H2RB55	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	ARATH|TAIR=AT5G61210|UniProtKB=Q9S7P9	SNAP25 homologous protein SNAP33	IC			PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04393	Ras Pathway	P04557	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	IDA	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02787	Vitamin B6 metabolism	P03242	Threonine synthase	ECOLI|EcoGene=EG11000|UniProtKB=P00934	Threonine synthase	ISS	11677608	PubMed	PTHR43455:SF2	THREONINE SYNTHASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04566	Stat 1/3	PANTR|Ensembl=ENSPTRG00000009200|UniProtKB=H2QD20	Signal transducer and activator of transcription	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	MYCTU|EnsemblGenome=Rv2445c|UniProtKB=P9WJH7	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00053	T cell activation	P01321	SLP-76	CHICK|Ensembl=ENSGALG00000002113|UniProtKB=Q9DG07	SLP-76 adaptor protein	IGI	9665884	PubMed	PTHR14098:SF1	LYMPHOCYTE CYTOSOLIC PROTEIN 2
P05912	Dopamine receptor mediated signaling pathway	P05963	MAO	DANRE|ZFIN=ZDB-GENE-040329-3|UniProtKB=Q6NSN2	Amine oxidase [flavin-containing]	ISS	8602220	PubMed	PTHR43563:SF2	AMINE OXIDASE  FLAVIN-CONTAINING
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00025	Hedgehog signaling pathway	P00682	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TRYB2|Gene=Tb09.211.0620|UniProtKB=Q38E94	Actin A	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00049	Parkinson disease	P01238	14-3-3	CHICK|Gene_ORFName=RCJMB04_1e8|UniProtKB=Q5ZMT0	14-3-3 protein epsilon	ISS	9450960	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MONDO|Ensembl=ENSMODG00000018204|UniProtKB=F6PGX6	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00020	FAS signaling pathway	P00601	c-Jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00055	Transcription regulation by bZIP transcription factor	P01392	TFIIH complex	RAT|RGD=1303309|UniProtKB=Q6MG20	General transcription factor II H, polypeptide 4	ISS			PTHR13152:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	RAT|RGD=3140|UniProtKB=Q62812	Myosin-9	ISS	89264452	PubMed	PTHR13140:SF317	MYOSIN-9
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00805	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00648	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00021	FGF signaling pathway	P00637	MKK4,7	DROME|FlyBase=FBgn0024326|UniProtKB=O61444	MAP kinase kinase 4, isoform A	NAS	7600581	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00005	Angiogenesis	P00244	MAPKAPK2/3	CANLF|Ensembl=ENSCAFG00000011432|UniProtKB=F1PZ82	Uncharacterized protein	ISS			PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DROME|FlyBase=FBgn0261854|UniProtKB=A1Z9X0	Atypical protein kinase C	ISS	15572354	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00047	PDGF signaling pathway	P01160	IP3 receptor	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CHICK|Ensembl=ENSGALG00000011809|UniProtKB=F1NMB0	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00010	B cell activation	P00385	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	IGI	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	MOUSE|MGI=MGI=1298218|UniProtKB=O88572	Low-density lipoprotein receptor-related protein 6	IDA	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	SCHPO|PomBase=SPBC32H8.07|UniProtKB=Q10282	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CHICK|Ensembl=ENSGALG00000008591|UniProtKB=E1BZF6	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00005	Angiogenesis	P00242	TCF	HUMAN|HGNC=11641|UniProtKB=Q9NQB0	Transcription factor 7-like 2	IDA	12356903	PubMed	PTHR10373:SF32	TRANSCRIPTION FACTOR 7-LIKE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04393	Ras Pathway	P04542	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00269	MAPK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	PHYIT|EnsemblGenome=PITG_06376|UniProtKB=D0N4Q3	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta, putative	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05754	Ggamma	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	IC	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000012539|UniProtKB=H2RC03	Uncharacterized protein	ISS			PTHR11824:SF7	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	MONDO|Ensembl=ENSMODG00000001775|UniProtKB=F6WJB1	Uncharacterized protein	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02724	Alanine biosynthesis	P02815	Branched chain amino acid aminotransferase	SYNY3|EnsemblGenome=BAA10792|UniProtKB=P54691	Probable branched-chain-amino-acid aminotransferase	ISS			PTHR42743:SF4	SUBFAMILY NOT NAMED
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P02738	De novo purine biosynthesis	P02891	GDP kinase	HUMAN|HGNC=7852|UniProtKB=O00746	Nucleoside diphosphate kinase, mitochondrial	ISS			PTHR11349:SF49	NUCLEOSIDE DIPHOSPHATE KINASE, MITOCHONDRIAL
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P06587	Nicotine pharmacodynamics pathway	P06612	CHRNB3	BOVIN|Ensembl=ENSBTAG00000014050|UniProtKB=F1MF30	Uncharacterized protein	ISS	15155845	PubMed	PTHR18945:SF75	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-3
P04398	p53 pathway feedback loops 2	P04657	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IDA	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	SCLS1|Gene=SS1G_08733|UniProtKB=A7ETS6	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00018	EGF receptor signaling pathway	P00547	PP2A	RAT|RGD=3380|UniProtKB=P63331	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	IGI	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00046	Oxidative stress response	P01135	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	TAS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	HUMAN|HGNC=4583|UniProtKB=Q16478	Glutamate receptor ionotropic, kainate 5	ISS	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	14505573	PubMed	PTHR10048:SF14	PI-3 KINASE
P00059	p53 pathway	G01579	PTEN	TAKRU|Ensembl=ENSTRUG00000009851|UniProtKB=H2TJ90	Uncharacterized protein	IGI	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	NAS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00056	VEGF signaling pathway	P01422	eNOS	RAT|RGD=3186|UniProtKB=Q62600	Nitric oxide synthase, endothelial	ISS	93055452	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P06664	Gonadotropin-releasing hormone receptor pathway	P06806	TBRIII	MOUSE|MGI=MGI=104637|UniProtKB=O88393	Transforming growth factor beta receptor type 3	RCA			PTHR14002:SF7	TRANSFORMING GROWTH FACTOR BETA RECEPTOR TYPE 3
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	DANRE|ZFIN=ZDB-GENE-040426-2487|UniProtKB=Q803G3	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IDA	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000000289|UniProtKB=F7A9T0	Uncharacterized protein	ISS	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05913	Enkephalin release	P05971	CREB	MONDO|Ensembl=ENSMODG00000015970|UniProtKB=F7FD05	Uncharacterized protein	ISS	1354612	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	CANLF|Gene=MMP9|UniProtKB=O18733	Matrix metalloproteinase-9	TAS	12834808	PubMed	PTHR10201:SF30	MATRIX METALLOPROTEINASE-9
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MOUSE|MGI=MGI=102891|UniProtKB=P51829	Adenylate cyclase type 7	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P04393	Ras Pathway	P04574	PLD	RAT|RGD=3349|UniProtKB=P70496	Phospholipase D1	ISS	15668389	PubMed	PTHR18896:SF57	PHOSPHOLIPASE D1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000039151|UniProtKB=F6R5F6	Uncharacterized protein	ISS	11701344	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00036	Interleukin signaling pathway	P00990	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04570	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	HUMAN|HGNC=132|UniProtKB=P60709	Actin, cytoplasmic 1	IDA	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P02723	Adenine and hypoxanthine salvage pathway	P02810	Adenine phosphoribosyl transferase	FUSNN|EnsemblGenome=FN1483|UniProtKB=Q8RDM9	Adenine phosphoribosyltransferase	ISS			PTHR32315:SF3	ADENINE PHOSPHORIBOSYLTRANSFERASE
P04398	p53 pathway feedback loops 2	G04714	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P02771	Pyrimidine Metabolism	P03124	Methylmalonate Semialdehyde Dehydrogenase	RAT|RGD=621556|UniProtKB=Q02253	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	IPI	1527093	PubMed	PTHR43866:SF3	METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE  ACYLATING , MITOCHONDRIAL
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	IC	176892	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00049	Parkinson disease	P01227	20S proteasome	TAKRU|Ensembl=ENSTRUG00000017560|UniProtKB=H2V726	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF16	PROTEASOME SUBUNIT ALPHA TYPE-2
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00057	Wnt signaling pathway	P01444	Wnt	RAT|RGD=621348|UniProtKB=Q9QXQ5	Protein Wnt-4	IDA	8717036	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00053	T cell activation	P01304	Csk	PANTR|Ensembl=ENSPTRG00000007282|UniProtKB=H2Q9T1	Tyrosine-protein kinase	ISS	7687537	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00010	B cell activation	P00398	IP3R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	IGI	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	BOVIN|Ensembl=ENSBTAG00000018035|UniProtKB=O46680	TGF-beta receptor type-1	IDA			PTHR23255:SF61	TGF-BETA RECEPTOR TYPE-1
P00010	B cell activation	P00385	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	8649368	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00034	Integrin signalling pathway	P00916	Ras	PANTR|Ensembl=ENSPTRG00000034469|UniProtKB=H2Q2V0	Uncharacterized protein	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P06959	CCKR signaling map	P07059	BCL2	HUMAN|HGNC=990|UniProtKB=P10415	Apoptosis regulator Bcl-2	RCA	15351698	PubMed	PTHR11256:SF11	APOPTOSIS REGULATOR BCL-2
P02781	Threonine biosynthesis	P03189	Aspartate kinase	ORYSJ|EnsemblGenome=OS09G0294000|UniProtKB=Q69LG7	Aspartate kinase-homoserine dehydrogenase	ISS			PTHR43070:SF3	HOMOSERINE DEHYDROGENASE
P00006	Apoptosis signaling pathway	P00302	ATF	MONDO|Ensembl=ENSMODG00000009514|UniProtKB=F7EVK3	Uncharacterized protein	ISS	11390664	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P06215	MYO signaling pathway	P06314	SMOX	DROME|FlyBase=FBgn0025800|UniProtKB=O96660	Mothers against decapentaplegic homolog	IEA	9395284	PubMed	PTHR13703:SF25	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3
P04393	Ras Pathway	P04548	ATF2	BOVIN|Ensembl=ENSBTAG00000002295|UniProtKB=F1N177	Uncharacterized protein	ISS	9819389	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P05730	Endogenous cannabinoid signaling	P05746	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00048	PI3 kinase pathway	P01199	Galpha	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS			PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	94280860	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P06664	Gonadotropin-releasing hormone receptor pathway	P06794	MAP2K1/2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	RCA	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00054	Toll receptor signaling pathway	P01368	MKK2	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00021	FGF signaling pathway	P00624	14-3-3	CANAL|CGD=CAL0000198341|UniProtKB=O42766	14-3-3 protein homolog	IGI	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00035	Interferon-gamma signaling pathway	P00960	PTP	CHICK|Ensembl=ENSGALG00000004821|UniProtKB=Q90687	Tyrosine-protein phosphatase non-receptor type 11	TAS	95163101	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	MACMU|Ensembl=ENSMMUG00000006646|UniProtKB=F7H415	Uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF151	CASEIN KINASE I ISOFORM GAMMA-3
P00012	Cadherin signaling pathway	P00464	Fyn	MOUSE|MGI=MGI=95602|UniProtKB=P39688	Tyrosine-protein kinase Fyn	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00005	Angiogenesis	P00249	PAK	MACMU|Ensembl=ENSMMUG00000001387|UniProtKB=F7D0B4	Uncharacterized protein	ISS	14580336	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00019	Endothelin signaling pathway	P00570	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00005	Angiogenesis	P00254	GTPase	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=69424|UniProtKB=Q99P84	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	7822322	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00012	Cadherin signaling pathway	P00465	TCF/LEF	DANRE|ZFIN=ZDB-GENE-980605-30|UniProtKB=Q9YHE8	Transcription factor 7-like 1-A	ISS	11266476	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00020	FAS signaling pathway	P00604	Pro-Caspase8	MOUSE|MGI=MGI=1336166|UniProtKB=O35732	CASP8 and FADD-like apoptosis regulator	IGI			PTHR10454:SF8	CASP8 AND FADD-LIKE APOPTOSIS REGULATOR
P00049	Parkinson disease	P01227	20S proteasome	SCHPO|PomBase=SPCC63.12c|UniProtKB=Q9Y7T8	Probable proteasome subunit beta type-3	TAS	12859888	PubMed	PTHR11599:SF62	PROTEASOME SUBUNIT BETA TYPE-3
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	15737619	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CAEEL|WormBase=WBGene00003186|UniProtKB=Q10664	Dual specificity mitogen-activated protein kinase kinase mek-2	IGI	176872	OMIM	PTHR24361:SF629	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1
P00030	Hypoxia response via HIF activation	P00819	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	CHICK|Ensembl=ENSGALG00000015176|UniProtKB=F1NU41	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00034	Integrin signalling pathway	P00911	B-Raf	MOUSE|MGI=MGI=88190|UniProtKB=P28028	Serine/threonine-protein kinase B-raf	IDA	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DANRE|ZFIN=ZDB-GENE-040426-1178|UniProtKB=Q7SY24	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04398	p53 pathway feedback loops 2	P04665	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=98953|UniProtKB=P04426	Proto-oncogene Wnt-1	IDA	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	PANTR|Ensembl=ENSPTRG00000002775|UniProtKB=H2RB55	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00056	VEGF signaling pathway	P01411	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	3035212	PubMed	PTHR24070:SF385	GTPASE HRAS
P00049	Parkinson disease	P01219	SAPK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00875	GEF	PANTR|Ensembl=ENSPTRG00000010378|UniProtKB=H2QF58	Uncharacterized protein	ISS	14623913	PubMed	PTHR22826:SF112	PROTO-ONCOGENE VAV
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IDA	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00059	p53 pathway	P01486	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05754	Ggamma	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P06587	Nicotine pharmacodynamics pathway	P06605	KCNK3/9	CHICK|Ensembl=ENSGALG00000016193|UniProtKB=E1BYI0	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	IDA	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00025	Hedgehog signaling pathway	P00693	Ubiquitin ligase	BOVIN|Ensembl=ENSBTAG00000021209|UniProtKB=F1N0L2	Uncharacterized protein	ISS			PTHR11254:SF402	E3 UBIQUITIN-PROTEIN LIGASE UBR5
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04558	p38	DROME|FlyBase=FBgn0024846|UniProtKB=O61443	Mitogen-activated protein kinase 14B	ISS	10514528	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00036	Interleukin signaling pathway	P00966	mTOR	CANLF|Ensembl=ENSCAFG00000016648|UniProtKB=E2R2L2	Uncharacterized protein	ISS	7518356	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00018	EGF receptor signaling pathway	P00550	Grb2	CAEBR|Gene=CBG16856|UniProtKB=A8XPY6	Protein CBR-SEM-5	ISS	11457149	PubMed	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IDA	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	HUMAN|HGNC=4580|UniProtKB=Q13002	Glutamate receptor ionotropic, kainate 2	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00057	Wnt signaling pathway	P01452	NFAT	MOUSE|MGI=MGI=103296|UniProtKB=P97305	Nuclear factor of activated T-cells, cytoplasmic 3	IDA	12787506	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P04393	Ras Pathway	P04567	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00049	Parkinson disease	P01227	20S proteasome	MACMU|Ensembl=ENSMMUG00000003509|UniProtKB=F7E2S4	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF10	PROTEASOME SUBUNIT ALPHA TYPE-3
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00643	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00055	Transcription regulation by bZIP transcription factor	P01390	TFIIA complex	RAT|RGD=620720|UniProtKB=O08950	Transcription initiation factor IIA subunit 2	ISS			PTHR10966:SF0	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00021	FGF signaling pathway	P00624	14-3-3	ENTHI|EnsemblGenome=EHI_098280|UniProtKB=C4LXB1	14-3-3 protein 2	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P04397	p53 pathway by glucose deprivation	P04636	S6K	BOVIN|Ensembl=ENSBTAG00000009175|UniProtKB=E1BLQ5	Uncharacterized protein	ISS	15116068	PubMed	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	MOUSE|MGI=MGI=103016|UniProtKB=P62137	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit	ISS	10433257	PubMed	PTHR11668:SF377	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-ALPHA CATALYTIC SUBUNIT
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04567	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CHICK|Ensembl=ENSGALG00000007509|UniProtKB=F1NM72	Uncharacterized protein	ISS	6309844	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00060	Ubiquitin proteasome pathway	P01491	E2	DANRE|ZFIN=ZDB-GENE-120312-1|UniProtKB=Q6PBX6	Ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)	ISS			PTHR24068:SF120	UBIQUITIN-CONJUGATING ENZYME E2D 2  UBC4/5 HOMOLOG, YEAST
P04393	Ras Pathway	P04570	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00011	Blood coagulation	P00456	HCII	XENTR|Xenbase=XB-GENE-6085731|UniProtKB=F6SP26	Uncharacterized protein (Fragment)	ISS	3132621	gi	PTHR11461:SF30	HEPARIN COFACTOR 2
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	ANOGA|EnsemblGenome=AGAP005913|UniProtKB=Q7Q6D2	AGAP005913-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	NEUCR|EnsemblGenome=EFNCRG00000008769|UniProtKB=P22126	Protein ras-1	ISS	7997267	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00025	Hedgehog signaling pathway	P00692	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02787	Vitamin B6 metabolism	P03236	Pyridoxamine phosphate oxidase	DEIRA|EnsemblGenome=DR_0495|UniProtKB=Q9RX20	Pyridoxine/pyridoxamine 5'-phosphate oxidase	ISS	10567266	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00029	Huntington disease	P00807	Actin	CHICK|Ensembl=ENSGALG00000014620|UniProtKB=F1N8P3	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	PANTR|Ensembl=ENSPTRG00000030907|UniProtKB=H2RDM0	C-C motif chemokine	ISS			PTHR12015:SF103	C-C MOTIF CHEMOKINE 4-RELATED
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IGI	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	EMENI|EnsemblGenome=CADANIAG00002670|UniProtKB=Q5BH99	G-protein beta subunit [Source:UniProtKB/TrEMBLAcc:O74214]	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00056	VEGF signaling pathway	P01407	Erk	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00034	Integrin signalling pathway	P00936	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IPI	7565716	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P02787	Vitamin B6 metabolism	P03242	Threonine synthase	METJA|EnsemblGenome=MJ_1465|UniProtKB=Q58860	Threonine synthase	ISS	8688087	PubMed	PTHR10314:SF5	THREONINE SYNTHASE 1, CHLOROPLASTIC
P00016	Cytoskeletal regulation by Rho GTPase	P00507	Rho	SCHPO|PomBase=SPAC20H4.11c|UniProtKB=Q9HE04	GTP-binding protein rho5	ISS	11973360	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00047	PDGF signaling pathway	P01159	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P06959	CCKR signaling map	P07042	CCK2R	HUMAN|HGNC=1571|UniProtKB=P32239	Gastrin/cholecystokinin type B receptor	RCA	18184106	PubMed	PTHR24243:SF45	GASTRIN/CHOLECYSTOKININ TYPE B RECEPTOR
P04393	Ras Pathway	P04555	PDK	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	12855688	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	8787761	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00010	B cell activation	P00370	NFkappaB	MACMU|Ensembl=ENSMMUG00000002990|UniProtKB=F7GVV0	Uncharacterized protein	ISS	9133421	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00005	Angiogenesis	P00219	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00036	Interleukin signaling pathway	P00973	PKB	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00034	Integrin signalling pathway	P00925	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	IDA	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DROME|FlyBase=FBgn0011743|UniProtKB=P45891	Actin-like protein 53D	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	SCHPO|PomBase=SPBC582.07c|UniProtKB=Q10335	Probable 26S proteasome regulatory subunit rpn7	ISS			PTHR14145:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00047	PDGF signaling pathway	P01152	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00021	FGF signaling pathway	P00640	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00011	Blood coagulation	P00460	FXI	HUMAN|HGNC=3551|UniProtKB=P00740	Coagulation factor IX	ISS	182609	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P05918	p38 MAPK pathway	P06021	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01154	Ras	DICPU|Gene=DICPUDRAFT_92731|UniProtKB=F0ZWE6	Putative uncharacterized protein rasG	ISS	7997267	PubMed	PTHR24070:SF282	RAS GTPASE-RELATED
P00056	VEGF signaling pathway	P01412	HSP27	ANOGA|EnsemblGenome=AGAP005547|UniProtKB=Q7Q724	AGAP005547-PA	ISS			PTHR11527:SF252	HEAT SHOCK PROTEIN BETA-11
P00011	Blood coagulation	P00422	FIXa	MACMU|Ensembl=ENSMMUG00000020064|UniProtKB=F7GHR4	Uncharacterized protein	ISS	182609	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00045	Notch signaling pathway	P01120	NIcs	HUMAN|HGNC=7882|UniProtKB=Q04721	Neurogenic locus notch homolog protein 2	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	BOVIN|Ensembl=ENSBTAG00000005800|UniProtKB=F1N3G8	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00036	Interleukin signaling pathway	P00981	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CHICK|Ensembl=ENSGALG00000015835|UniProtKB=F1NZT2	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00046	Oxidative stress response	P01129	JNK1/2	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00760	Gtalpha	PANTR|Ensembl=ENSPTRG00000014949|UniProtKB=H2QMN3	Uncharacterized protein	ISS	6264430	PubMed	PTHR10218:SF67	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DROME|FlyBase=FBgn0030011|UniProtKB=Q9W3J1	Gbeta5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P02726	Aminobutyrate degradation	P02824	Succinate semi-aldehyde dehydrogenase	PANTR|Gene=ALDH5A1|UniProtKB=Q6A2H0	Succinate-semialdehyde dehydrogenase, mitochondrial	ISS	12891648	PubMed	PTHR43353:SF5	SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL
P00034	Integrin signalling pathway	P00920	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	IC	10477300	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00015	Circadian clock system	P00502	Casein kinase I	CANLF|Ensembl=ENSCAFG00000006059|UniProtKB=F1Q126	Uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00057	Wnt signaling pathway	P01457	GBeta	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IDA	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00059	p53 pathway	P01486	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00228	Grb7	RAT|RGD=619759|UniProtKB=Q9QZC5	Growth factor receptor-bound protein 7	ISS	10521483	PubMed	PTHR11243:SF25	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 7
P00047	PDGF signaling pathway	P01143	ERK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IDA	7937853	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00047	PDGF signaling pathway	P01153	GSK3	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P02740	De novo pyrimidine ribonucleotides biosythesis	P02928	Dihydroorotase	METJA|EnsemblGenome=MJ_1490|UniProtKB=Q58885	Dihydroorotase	ISS			PTHR43668:SF2	ALLANTOINASE
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	HUMAN|HGNC=4599|UniProtKB=Q14831	Metabotropic glutamate receptor 7	ISS	12351712	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P02740	De novo pyrimidine ribonucleotides biosythesis	P02924	Uridylate kinase	SCHPO|PomBase=SPCC1795.05c|UniProtKB=O59771	Uridylate kinase	ISS			PTHR23359:SF107	UMP-CMP KINASE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	RCA	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00012	Cadherin signaling pathway	P00477	GSK3beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01438	PP2A	RAT|RGD=1308022|UniProtKB=D3ZDI7	Protein Ppp2r5a	ISS	12110603	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01177	P110ACT	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00005	Angiogenesis	P00220	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	8837781	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00034	Integrin signalling pathway	P00927	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00057	Wnt signaling pathway	P01455	Smad4	ORNAN|Ensembl=ENSOANG00000008117|UniProtKB=F7F4A2	Mothers against decapentaplegic homolog	ISS	10693808	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=69424|UniProtKB=Q99P84	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	15611108	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00944	Actin	HUMAN|HGNC=17780|UniProtKB=Q562R1	Beta-actin-like protein 2	IPI	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	DANRE|ZFIN=ZDB-GENE-010705-1|UniProtKB=Q90Z40	Guanine nucleotide-binding protein subunit gamma	IDA	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00020	FAS signaling pathway	P00611	Gelsolin	HUMAN|HGNC=4620|UniProtKB=P06396	Gelsolin	IGI	9323209	PubMed	PTHR11977:SF29	GELSOLIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MACMU|Ensembl=ENSMMUG00000010339|UniProtKB=F6R9V5	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF67	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-1
P00052	TGF-beta signaling pathway	P01275	P38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P06213	DPP signaling pathway	P06288	MAD	DROME|FlyBase=FBgn0011648|UniProtKB=P42003	Protein mothers against dpp	IGI	7768443	PubMed	PTHR13703:SF40	PROTEIN MOTHERS AGAINST DPP
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00048	PI3 kinase pathway	P01188	Gbetagamma	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00047	PDGF signaling pathway	P01153	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS			PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	MOUSE|MGI=MGI=1338071|UniProtKB=O88351	Inhibitor of nuclear factor kappa-B kinase subunit beta	IDA	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	RAT|RGD=1308692|UniProtKB=A0A0G2JTY4	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 (Predicted), isoform CRA_b	ISS	12015605	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P05915	Opioid proenkephalin pathway	P05987	peptide F	XENTR|Xenbase=XB-GENE-942760|UniProtKB=F6Y5F6	Uncharacterized protein	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00036	Interleukin signaling pathway	P00983	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IC	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	RAT|RGD=3375|UniProtKB=P62138	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit	ISS	10433257	PubMed	PTHR11668:SF377	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-ALPHA CATALYTIC SUBUNIT
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00053	T cell activation	P01306	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P02721	ATP synthesis	P02791	F1 alpha	MACMU|Ensembl=ENSMMUG00000003570|UniProtKB=F7ETD0	ATP synthase subunit alpha	ISS	11479684	PubMed	PTHR43089:SF4	ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00035	Interferon-gamma signaling pathway	P00956	SOCS	BOVIN|Ensembl=ENSBTAG00000022622|UniProtKB=Q2HJ53	Cytokine-inducible SH2-containing protein	ISS	15032587	PubMed	PTHR44649:SF1	CYTOKINE-INDUCIBLE SH2-CONTAINING PROTEIN
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	RAT|RGD=69430|UniProtKB=P32851	Syntaxin-1A	TAS	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00029	Huntington disease	P00779	TBP	MOUSE|MGI=MGI=101838|UniProtKB=P29037	TATA-box-binding protein	ISS	11988536	PubMed	PTHR10126:SF20	TATA-BOX-BINDING PROTEIN
P00005	Angiogenesis	P00187	beta catenin	MACMU|Ensembl=ENSMMUG00000014627|UniProtKB=F7GNE4	Catenin beta-1	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P04393	Ras Pathway	P04547	Ras	CHICK|Ensembl=ENSGALG00000014033|UniProtKB=E1BTS2	Uncharacterized protein	ISS	9869449	PubMed	PTHR24070:SF186	GTPASE KRAS
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	IDA	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00047	PDGF signaling pathway	P01142	p90RSK	MOUSE|MGI=MGI=104558|UniProtKB=P18653	Ribosomal protein S6 kinase alpha-1	ISS	12769834	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00049	Parkinson disease	P01208	Hsp70	CAEBR|Gene=CBG22024|UniProtKB=A8Y1C9	Protein CBR-HSP-70	ISS	12150907	PubMed	PTHR19375:SF207	HEAT SHOCK PROTEIN
P02741	Flavin biosynthesis	P02933	Pyrimidine deaminase	LEPIN|EnsemblGenome=LA_1144|UniProtKB=Q8F704	Pyrimidine deaminase, riboflavin biosynthesis	ISS			PTHR45091:SF1	SUBFAMILY NOT NAMED
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00019	Endothelin signaling pathway	P00566	ERK	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	ISS	6319455	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00006	Apoptosis signaling pathway	P00272	ASK1	BOVIN|Ensembl=ENSBTAG00000009065|UniProtKB=F1MXH6	Uncharacterized protein	ISS	12566458	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00047	PDGF signaling pathway	P01159	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00019	Endothelin signaling pathway	P00566	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05731	GABA-B receptor II signaling	P05755	Gbeta	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000005917|UniProtKB=F6QM53	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00034	Integrin signalling pathway	P00936	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	IPI	8700226	PubMed	PTHR10048:SF14	PI-3 KINASE
P00021	FGF signaling pathway	P00645	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P02747	Histidine biosynthesis	P02991	Histidinephosphate aminotransferase	SULSO|EnsemblGenome=SSO0448|UniProtKB=Q97ZX4	Histidinol-phosphate aminotransferase, putative (HisC-like)	ISS			PTHR43643:SF3	SUBFAMILY NOT NAMED
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00020	FAS signaling pathway	P00599	Caspase3	CANLF|Ensembl=ENSCAFG00000007750|UniProtKB=Q8MKI5	Caspase-3	IGI	9323209	PubMed	PTHR10454:SF198	CASPASE-3
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02765	Phenylalanine biosynthesis	P03100	Chorismate mutase	NEUCR|EnsemblGenome=EFNCRG00000008062|UniProtKB=Q7S8R4	Chorismate mutase	ISS			PTHR21145:SF0	CHORISMATE MUTASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	XENTR|Xenbase=XB-GENE-491618|UniProtKB=Q6P378	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	RCA	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00050	Plasminogen activating cascade	P01254	pro-MMP-13	RAT|RGD=620196|UniProtKB=P23097	Collagenase 3 (Fragment)	ISS	12834808	PubMed	PTHR10201:SF165	COLLAGENASE 3
P05730	Endogenous cannabinoid signaling	P05751	Galpha	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04661	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00047	PDGF signaling pathway	P01154	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00006	Apoptosis signaling pathway	P00310	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00775	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12874273	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00057	Wnt signaling pathway	P01438	PP2A	MONDO|Ensembl=ENSMODG00000014177|UniProtKB=F6U7A6	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	MOUSE|MGI=MGI=103307|UniProtKB=P54285	Voltage-dependent L-type calcium channel subunit beta-3	IC			PTHR11824:SF8	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-3
P05915	Opioid proenkephalin pathway	P05994	G-protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	12488551	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IGI	129387	gi	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P06959	CCKR signaling map	P07117	BCL2L1	HUMAN|HGNC=992|UniProtKB=Q07817	Bcl-2-like protein 1	RCA	18719002	PubMed	PTHR11256:SF12	BCL-2-LIKE PROTEIN 1
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	MACMU|Ensembl=ENSMMUG00000012470|UniProtKB=F7G0B2	Uncharacterized protein	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P02761	Pantothenate biosynthesis	P03068	Pantoate-beta-alanine ligase	ORYSJ|EnsemblGenome=OS03G0851800|UniProtKB=O24210	Pantoate--beta-alanine ligase	ISS			PTHR21299:SF1	PANTOATE--BETA-ALANINE LIGASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00199	JNKK1	BOVIN|Ensembl=ENSBTAG00000012103|UniProtKB=A5PJP8	MAP2K4 protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00054	Toll receptor signaling pathway	P01352	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00780	Microtubule	BOVIN|Gene=TUBB6|UniProtKB=Q2HJ81	Tubulin beta-6 chain	ISS	12932731	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00005	Angiogenesis	P00254	GTPase	MONDO|Ensembl=ENSMODG00000012981|UniProtKB=F7CS91	Uncharacterized protein	ISS	10556059	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01138	MKK4	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00036	Interleukin signaling pathway	P00975	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04393	Ras Pathway	P04542	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00093	Tip60	MACMU|Ensembl=ENSMMUG00000019339|UniProtKB=F6PW11	Uncharacterized protein	ISS			PTHR12345:SF12	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 2
P00018	EGF receptor signaling pathway	P00564	Rac	ENTHI|EnsemblGenome=EHI_129750|UniProtKB=C4M5Q7	Rho family GTPase	IGI	98264868	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00034	Integrin signalling pathway	P00947	Laminin	PANTR|Ensembl=ENSPTRG00000021480|UniProtKB=H2R4F9	Uncharacterized protein	ISS	2538453	PubMed	PTHR10574:SF240	LAMININ SUBUNIT GAMMA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	IDA	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04398	p53 pathway feedback loops 2	P04658	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MONDO|Ensembl=ENSMODG00000018204|UniProtKB=F6PGX6	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00005	Angiogenesis	P00223	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	MONDO|Ensembl=ENSMODG00000020977|UniProtKB=F6S5B1	Uncharacterized protein (Fragment)	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ARATH|TAIR=AT3G45640|UniProtKB=Q39023	Mitogen-activated protein kinase 3	IDA			PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01305	Calmodulin	MONDO|Ensembl=ENSMODG00000023174|UniProtKB=F7D7P2	Uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF197	CALMODULIN-LIKE PROTEIN 3
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00034	Integrin signalling pathway	P00924	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IPI	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00557	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00020	FAS signaling pathway	P00615	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00005	Angiogenesis	P00217	STAT3	MACMU|Ensembl=ENSMMUG00000010707|UniProtKB=F7G8G5	Signal transducer and activator of transcription	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P02722	Acetate utilization	P02802	Phosphate acetyltransferase	DEIRA|EnsemblGenome=DR_0073|UniProtKB=Q9RY77	Phosphate acetyltransferase	ISS			PTHR43356:SF3	PHOSPHATE ACETYLTRANSFERASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00056	VEGF signaling pathway	P01423	p38MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P06664	Gonadotropin-releasing hormone receptor pathway	P06850	PKCs(3)	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	RCA	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00034	Integrin signalling pathway	P00948	Rho	EMENI|EnsemblGenome=CADANIAG00003322|UniProtKB=Q9C3Y4	GTP-binding protein rhoA	ISS	11973360	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	PANTR|Ensembl=ENSPTRG00000016548|UniProtKB=H2QQC5	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01446	Calcineurin	CAEEL|WormBase=WBGene00006527|UniProtKB=Q0G819	Serine/threonine-protein phosphatase 2B catalytic subunit	IDA	12015605	PubMed	PTHR11668:SF118	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	DICPU|Gene=DICPUDRAFT_92731|UniProtKB=F0ZWE6	Putative uncharacterized protein rasG	ISS	7997267	PubMed	PTHR24070:SF282	RAS GTPASE-RELATED
P00013	Cell cycle	P00480	Proteasome	MACMU|Ensembl=ENSMMUG00000011906|UniProtKB=F7HMX1	26S proteasome non-ATPase regulatory subunit 14	ISS	9727008	PubMed	PTHR10410:SF5	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 14
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	XENTR|Xenbase=XB-GENE-969601|UniProtKB=Q28H40	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P05918	p38 MAPK pathway	P06034	MKK4	CHICK|Ensembl=ENSGALG00000001001|UniProtKB=F1P3T1	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P02723	Adenine and hypoxanthine salvage pathway	P02813	Inosine phosphorylase	STRCO|Gene=CAD30908|UniProtKB=Q9EWV2	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00056	VEGF signaling pathway	P01413	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	ISS	1171954	gi	PTHR10048:SF14	PI-3 KINASE
P04393	Ras Pathway	P04552	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	DANRE|ZFIN=ZDB-GENE-051202-2|UniProtKB=Q6ZM67	Uncharacterized protein	ISS	92049750	PubMed	PTHR44391:SF3	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01456	beta-arrestin	CANLF|Ensembl=ENSCAFG00000005415|UniProtKB=F1PQM2	Uncharacterized protein	ISS	11742073	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00036	Interleukin signaling pathway	P00970	Interleukin	MOUSE|MGI=MGI=1270855|UniProtKB=O54824	Pro-interleukin-16	IC			PTHR11324:SF2	PRO-INTERLEUKIN-16
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	ORNAN|Ensembl=ENSOANG00000007724|UniProtKB=F6QTB5	Uncharacterized protein	ISS	12932731	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	MOUSE|MGI=MGI=1346037|UniProtKB=Q9WTL4	Insulin receptor-related protein	ISS	6754360	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01149	MNK1/2	MACMU|Ensembl=ENSMMUG00000020162|UniProtKB=F6TJV6	Uncharacterized protein	ISS	9155018	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P04393	Ras Pathway	P04558	p38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	IDA	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00036	Interleukin signaling pathway	P00973	PKB	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04393	Ras Pathway	P04541	p90RSK	RAT|RGD=620676|UniProtKB=F1M7N7	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	ORNAN|Ensembl=ENSOANG00000006877|UniProtKB=F7CQF2	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00012	Cadherin signaling pathway	P00475	Frizzled	MACMU|Ensembl=ENSMMUG00000006912|UniProtKB=F7EZ48	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF86	FRIZZLED-10
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	HUMAN|HGNC=5975|UniProtKB=Q14627	Interleukin-13 receptor subunit alpha-2	IC	12816724	PubMed	PTHR23036:SF101	INTERLEUKIN-13 RECEPTOR SUBUNIT ALPHA-2
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01148	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12186904	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P02775	Salvage pyrimidine ribonucleotides	P03151	Uracil phosphoribosyl  transferase	PANTR|Ensembl=ENSPTRG00000022040|UniProtKB=H2QYT7	Uncharacterized protein	ISS			PTHR10285:SF90	URACIL PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	DROME|FlyBase=FBgn0004598|UniProtKB=P30432	Furin-like protease 2	IDA	10956649	PubMed	PTHR42884:SF2	FURIN-LIKE PROTEASE 2
P00006	Apoptosis signaling pathway	P00267	MADD	MOUSE|MGI=MGI=2444672|UniProtKB=Q80U28	MAP kinase-activating death domain protein	ISS	9115275	PubMed	PTHR13008:SF7	MAP KINASE-ACTIVATING DEATH DOMAIN PROTEIN
P00049	Parkinson disease	P01236	Casein kinase II	IXOSC|EnsemblGenome=ISCW014459|UniProtKB=B7QIS2	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P02772	Pyruvate metabolism	P03136	Malic enzyme	MOUSE|MGI=MGI=97043|UniProtKB=P06801	NADP-dependent malic enzyme	ISS	9954437	gi	PTHR23406:SF17	NADP-DEPENDENT MALIC ENZYME
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	BOVIN|Gene=CSNK2A1|UniProtKB=P68399	Casein kinase II subunit alpha	ISS	10617630	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00053	T cell activation	P01332	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01425	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	3045562	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	RAT|RGD=62029|UniProtKB=P02563	Myosin-6	ISS	89264452	PubMed	PTHR13140:SF721	MYOSIN-6
P00053	T cell activation	P01336	Jnk	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	SCLS1|EnsemblGenome=SS1G_03482|UniProtKB=A7EDU2	Guanine nucleotide-binding protein beta subunit	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00059	p53 pathway	P04616	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	11256888	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00018	EGF receptor signaling pathway	P00564	Rac	MACMU|Ensembl=ENSMMUG00000021075|UniProtKB=F7GY91	Uncharacterized protein	ISS	11756405	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00010	B cell activation	P00398	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IGI	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01142	p90RSK	BOVIN|Gene=RPS6KB1|UniProtKB=Q6TJY3	Ribosomal protein S6 kinase beta-1	ISS	11861821	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06010	proopiomelanocortin	DANRE|ZFIN=ZDB-GENE-041014-294|UniProtKB=Q5SPP4	Uncharacterized protein	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00012	Cadherin signaling pathway	P00471	Cadherin	DROME|FlyBase=FBgn0024836|UniProtKB=Q9V5N8	Protocadherin-like wing polarity protein stan	ISS	8120095	PubMed	PTHR24026:SF51	PROTOCADHERIN-LIKE WING POLARITY PROTEIN STAN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04393	Ras Pathway	P04570	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00779	TBP	DANRE|ZFIN=ZDB-GENE-030616-563|UniProtKB=Q7SXL3	TATA-box-binding protein	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00021	FGF signaling pathway	P00631	Grb2	MOUSE|MGI=MGI=1918770|UniProtKB=Q9CX99	GRB2-related adapter protein	ISS	51702266	gi	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00049	Parkinson disease	P01211	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00780	Microtubule	PHYPA|Gene=PHYPADRAFT_213086|UniProtKB=A9SJR1	Beta-tubulin 4	ISS	12932731	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00552	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IGI	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P04393	Ras Pathway	P04542	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000016097|UniProtKB=E1B9S9	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00020	FAS signaling pathway	P00594	Caspase8	RAT|RGD=620945|UniProtKB=Q9JHX4	Caspase-8	IGI	8681376	PubMed	PTHR10454:SF162	CASPASE-8
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00055	Transcription regulation by bZIP transcription factor	P01398	TFIIEalpha	CANLF|Ensembl=ENSCAFG00000011306|UniProtKB=E2R3P2	Uncharacterized protein	ISS	92065982	PubMed	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00018	EGF receptor signaling pathway	P00563	Gab	MACMU|Ensembl=ENSMMUG00000017477|UniProtKB=F6VIK2	Uncharacterized protein	ISS	18105042	gi	PTHR12156:SF4	GRB2-ASSOCIATED-BINDING PROTEIN 2
P06959	CCKR signaling map	P07119	MAPK3	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	RCA	15153424	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01446	Calcineurin	CRYNJ|EnsemblGenome=CND00260|UniProtKB=P0CM54	Calcineurin subunit B	ISS	12015605	PubMed	PTHR23056:SF4	PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1
P04396	Vitamin D metabolism and pathway	P04600	DBP	MACMU|Ensembl=ENSMMUG00000023241|UniProtKB=F6WR34	Uncharacterized protein	ISS	11799400	PubMed	PTHR11385:SF11	VITAMIN D-BINDING PROTEIN
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00057	Wnt signaling pathway	P01443	Phospholipase C	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00219	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00924	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	12068308	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00577	PI3K	DANRE|ZFIN=ZDB-GENE-040426-1128|UniProtKB=F1RB17	Uncharacterized protein	ISS			PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_188187|UniProtKB=E9GJ31	Guanine nucleotide binding protein, q polypeptide	ISS	1333286	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	RAT|RGD=61858|UniProtKB=P70507	G protein-coupled receptor kinase 4	IDA	8288567	PubMed	PTHR24355:SF14	G PROTEIN-COUPLED RECEPTOR KINASE 4
P00034	Integrin signalling pathway	P00948	Rho	CANAL|CGD=CAL0000192659|UniProtKB=O42825	GTP-binding protein RHO1	IGI	11973360	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=1351339|UniProtKB=Q14BI2	Metabotropic glutamate receptor 2	ISS	12488551	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00019	Endothelin signaling pathway	P00589	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IGI	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00047	PDGF signaling pathway	P01171	PLCgamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00034	Integrin signalling pathway	P00922	Collagen	MONDO|Ensembl=ENSMODG00000011945|UniProtKB=F7CV32	Uncharacterized protein	ISS	10778855	PubMed	PTHR24023:SF569	COLLAGEN ALPHA-1 I  CHAIN
P00005	Angiogenesis	P00219	PKC	RAT|RGD=1308054|UniProtKB=Q5XIS9	Serine/threonine-protein kinase D2	ISS	11062248	PubMed	PTHR22968:SF12	SERINE/THREONINE-PROTEIN KINASE D2
P00006	Apoptosis signaling pathway	P00310	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00566	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00036	Interleukin signaling pathway	P00977	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00047	PDGF signaling pathway	P01150	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02738	De novo purine biosynthesis	P02902	ADP reductase	SCHPO|PomBase=SPAC1F7.05|UniProtKB=P36602	Ribonucleoside-diphosphate reductase large chain	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00010	B cell activation	P00383	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IDA	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00009	Axon guidance mediated by netrin	P00366	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00011	Blood coagulation	P00422	FIXa	HUMAN|HGNC=3551|UniProtKB=P00740	Coagulation factor IX	ISS	182609	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00013	Cell cycle	P00483	Cyclin E	MOUSE|MGI=MGI=88316|UniProtKB=Q61457	G1/S-specific cyclin-E1	ISS	12628165	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P02738	De novo purine biosynthesis	P02909	GDP reductase	BACSU|EnsemblGenome=BSU20060|UniProtKB=O31875	Ribonucleoside-diphosphate reductase NrdEB subunit alpha	ISS			PTHR11573:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT ALPHA
P00017	DNA replication	P00533	Pol delta	SCHPO|PomBase=SPAC27E2.05|UniProtKB=P87324	DNA polymerase subunit delta-2	ISS	21848401	PubMed	PTHR10416:SF0	DNA POLYMERASE DELTA SUBUNIT 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00310	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01457	GBeta	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IDA	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00029	Huntington disease	G01532	PolyQ HTT	RAT|RGD=68337|UniProtKB=P51111	Huntingtin	TAS	9462744	PubMed	PTHR10170:SF10	HUNTINGTIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00557	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	IGI	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	IC	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04380	Cortocotropin releasing factor receptor signaling pathway	P04452	proopiomelanocortin	XENTR|Xenbase=XB-GENE-483703|UniProtKB=Q5M8F2	Proopiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MACMU|Ensembl=ENSMMUG00000016675|UniProtKB=F6VTB5	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00047	PDGF signaling pathway	P01150	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00056	VEGF signaling pathway	P01415	MAPKAPK2/3	HUMAN|HGNC=6888|UniProtKB=Q16644	MAP kinase-activated protein kinase 3	IDA	11335727	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P00049	Parkinson disease	P01211	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00645	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	PANTR|Ensembl=ENSPTRG00000001477|UniProtKB=H2Q0A5	Tyrosine-protein kinase receptor	ISS	10226785	PubMed	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00025	Hedgehog signaling pathway	P00683	Slimb	MOUSE|MGI=MGI=2144023|UniProtKB=Q5SRY7	F-box/WD repeat-containing protein 11	ISS	10074433	PubMed	PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P00011	Blood coagulation	P00460	FXI	MACMU|Ensembl=ENSMMUG00000020064|UniProtKB=F7GHR4	Uncharacterized protein	ISS	182609	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	RAT|RGD=2845|UniProtKB=P19327	5-hydroxytryptamine receptor 1A	IEA	12441358	PubMed	PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	CANLF|Ensembl=ENSCAFG00000006455|UniProtKB=E2R5N5	Uncharacterized protein	ISS	10225435	PubMed	PTHR10539:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00029	Huntington disease	P00780	Microtubule	PHYPA|Gene=PHYPADRAFT_165677|UniProtKB=Q6TYR3	Beta-tubulin 5	ISS	9454836	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01154	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00007	Axon guidance mediated by semaphorins	P00340	Rac	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00005	Angiogenesis	P00219	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CAEEL|WormBase=WBGene00000055|UniProtKB=P48180	Acetylcholine receptor subunit alpha-type acr-16	IC	11404397	PubMed	PTHR18945:SF578	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-TYPE ACR-16
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00036	Interleukin signaling pathway	P00983	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00048	PI3 kinase pathway	P01177	P110ACT	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04384	Gamma-aminobutyric acid synthesis	P04481	Succinic semialdehyde dehydrogenase	ARATH|TAIR=AT1G79440|UniProtKB=Q9SAK4	Succinate-semialdehyde dehydrogenase, mitochondrial	IC	12891648	PubMed	PTHR43353:SF5	SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00019	Endothelin signaling pathway	P00573	signal peptidase	PANTR|Ensembl=ENSPTRG00000007404|UniProtKB=H2QA06	Signal peptidase complex catalytic subunit SEC11	ISS	2674115	PubMed	PTHR10806:SF8	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11A-RELATED
P00034	Integrin signalling pathway	P00919	Arf6	CANLF|Ensembl=ENSCAFG00000024150|UniProtKB=E2RHL4	Uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00009	Axon guidance mediated by netrin	P00360	DCC/UNC-40	MONDO|Ensembl=ENSMODG00000011028|UniProtKB=F7F4D5	Uncharacterized protein	ISS	12798294	PubMed	PTHR44146:SF3	NETRIN RECEPTOR DCC
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00012	Cadherin signaling pathway	P00477	GSK3beta	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00311	GCKR	RAT|RGD=1305463|UniProtKB=D3Z8I4	Mitogen-activated protein kinase kinase kinase kinase	ISS			PTHR24361:SF88	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 1
P06959	CCKR signaling map	P07153	RSK1/2	HUMAN|HGNC=10430|UniProtKB=Q15418	Ribosomal protein S6 kinase alpha-1	RCA	7697796	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	TAS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00034	Integrin signalling pathway	P00906	Rap1	MACMU|Ensembl=ENSMMUG00000016588|UniProtKB=F6VPD5	Ras-related protein Rap-2c	ISS	8576107	PubMed	PTHR24070:SF200	RAS-RELATED PROTEIN RAP-2C
P00056	VEGF signaling pathway	P01423	p38MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00024	Glycolysis	P00672	Phosphofructokinase-1	MOUSE|MGI=MGI=97547|UniProtKB=P12382	ATP-dependent 6-phosphofructokinase, liver type	RCA			PTHR13697:SF14	ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE, LIVER TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04398	p53 pathway feedback loops 2	P04669	ATM	YEAST|SGD=S000000340|UniProtKB=P38111	Serine/threonine-protein kinase MEC1	ISS			PTHR11139:SF69	SERINE/THREONINE-PROTEIN KINASE ATR
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	11035810	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	ORNAN|Ensembl=ENSOANG00000013961|UniProtKB=F6VPY1	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=5289|UniProtKB=P28221	5-hydroxytryptamine receptor 1D	IDA	11701344	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DANRE|ZFIN=ZDB-GENE-030131-55|UniProtKB=Q6XNL8	Actin	IEP	14684598	PubMed	PTHR11937:SF263	ACTIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IDA	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	XENTR|Xenbase=XB-GENE-976753|UniProtKB=Q0VFR6	Syntaxin 1A (Brain)	ISS	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P04393	Ras Pathway	P04547	Ras	MONDO|Gene=KRAS|UniProtKB=Q07983	GTPase KRas	ISS	99084794	PubMed	PTHR24070:SF186	GTPASE KRAS
P00021	FGF signaling pathway	P00627	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	21071228	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00007	Axon guidance mediated by semaphorins	P00340	Rac	CHICK|Ensembl=ENSGALG00000002859|UniProtKB=F6UBD2	Uncharacterized protein	ISS	15470041	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=98329|UniProtKB=P30935	Somatostatin receptor type 3	IDA	12562507	PubMed	PTHR24229:SF42	SOMATOSTATIN RECEPTOR TYPE 3
P00045	Notch signaling pathway	P01119	NIct	HUMAN|HGNC=7882|UniProtKB=Q04721	Neurogenic locus notch homolog protein 2	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00021	FGF signaling pathway	P00632	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01307	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CAEBR|Gene=CBG23091|UniProtKB=A8Y4Q9	Protein CBR-ACT-2	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	MOUSE|MGI=MGI=97453|UniProtKB=P35454	Oxytocin-neurophysin 1	ISS	1706187	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P02742	Tetrahydrofolate biosynthesis	P02941	Dihydroneopterin aldolase	GLOVI|Gene=BAC89428|UniProtKB=Q7NKJ0	7,8-dihydroneopterin aldolase	ISS			PTHR42844:SF1	DIHYDRONEOPTERIN ALDOLASE
P00052	TGF-beta signaling pathway	P01275	P38	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02723	Adenine and hypoxanthine salvage pathway	P02809	Xanthine dehydrogenase	BOVIN|Gene=XDH|UniProtKB=P80457	Xanthine dehydrogenase/oxidase	ISS	4336760	gi	PTHR11908:SF80	XANTHINE DEHYDROGENASE/OXIDASE
P00019	Endothelin signaling pathway	P00566	ERK	ARATH|TAIR=AT1G01560|UniProtKB=Q9LMM5	Mitogen-activated protein kinase 11	ISS			PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P00052	TGF-beta signaling pathway	P01285	TAK	PANTR|Ensembl=ENSPTRG00000018427|UniProtKB=H2RCY2	Mitogen-activated protein kinase kinase kinase 7	RCA			PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	PYRAE|EnsemblGenome=PAE0974|UniProtKB=Q8ZY26	Adenylosuccinate synthetase	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00005	Angiogenesis	P00187	beta catenin	CHICK|Ensembl=ENSGALG00000011905|UniProtKB=F1NHT7	Uncharacterized protein	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00057	Wnt signaling pathway	P01438	PP2A	CANLF|Ensembl=ENSCAFG00000015787|UniProtKB=F6V7D9	Uncharacterized protein	ISS	11007767	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00049	Parkinson disease	P01212	p38 MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00047	PDGF signaling pathway	P01174	Rho	RAT|RGD=735202|UniProtKB=Q6TLK4	Rho GTPase-activating protein 27	ISS	8288572	PubMed	PTHR23181:SF2	RHO GTPASE-ACTIVATING PROTEIN 27
P00011	Blood coagulation	P00445	FXa	RAT|RGD=61850|UniProtKB=Q63207	Coagulation factor X	ISS	8393340	gi	PTHR44064:SF3	COAGULATION FACTOR X
P00048	PI3 kinase pathway	P01177	P110ACT	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	IGI	14505573	PubMed	PTHR10048:SF14	PI-3 KINASE
P00057	Wnt signaling pathway	P01452	NFAT	MOUSE|MGI=MGI=1920431|UniProtKB=Q8K120	Nuclear factor of activated T-cells, cytoplasmic 4	IDA	12787506	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00586	Gq	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	HUMAN|HGNC=17780|UniProtKB=Q562R1	Beta-actin-like protein 2	IC	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00054	Toll receptor signaling pathway	P01339	TLR4	RAT|RGD=3870|UniProtKB=Q9QX05	Toll-like receptor 4	ISS			PTHR44568:SF1	TOLL-LIKE RECEPTOR 4
P00006	Apoptosis signaling pathway	P00321	HSP70	HUMAN|HGNC=5239|UniProtKB=P17066	Heat shock 70 kDa protein 6	ISS	12150907	PubMed	PTHR19375:SF168	HEAT SHOCK 70 KDA PROTEIN 6-RELATED
P00018	EGF receptor signaling pathway	P00551	Akt	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	IGI	12655147	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00046	Oxidative stress response	P01137	MNK1/2	HUMAN|HGNC=7110|UniProtKB=Q9BUB5	MAP kinase-interacting serine/threonine-protein kinase 1	RCA	Q9BUB5	SPACC	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00005	Angiogenesis	P00181	SHP2	RAT|RGD=3447|UniProtKB=P41499	Tyrosine-protein phosphatase non-receptor type 11	ISS	1382983	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	RAT|RGD=2736|UniProtKB=P35439	Glutamate receptor ionotropic, NMDA 1	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00010	B cell activation	P00375	Calmodulin	TAKRU|Ensembl=ENSTRUG00000003442|UniProtKB=H2S6Q5	Uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF197	CALMODULIN-LIKE PROTEIN 3
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00005	Angiogenesis	P00203	Erk	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00944	Actin	MOUSE|MGI=MGI=87906|UniProtKB=P63260	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00046	Oxidative stress response	P01131	MKP5	HUMAN|HGNC=3071|UniProtKB=Q16690	Dual specificity protein phosphatase 5	TAS			PTHR10159:SF40	DUAL SPECIFICITY PROTEIN PHOSPHATASE 5
P05918	p38 MAPK pathway	P06025	SRF	BOVIN|Ensembl=ENSBTAG00000012777|UniProtKB=E1BJP4	Uncharacterized protein	ISS	15326221	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00029	Huntington disease	P00807	Actin	HUMAN|HGNC=129|UniProtKB=P68133	Actin, alpha skeletal muscle	IDA	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00019	Endothelin signaling pathway	P00566	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IGI	7937853	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	RAT|RGD=3140|UniProtKB=Q62812	Myosin-9	IC	89264452	PubMed	PTHR13140:SF317	MYOSIN-9
P00051	TCA cycle	P01274	Succinyl CoA Synthetase	ECOLI|EcoGene=EG10982|UniProtKB=P0AGE9	Succinyl-CoA ligase [ADP-forming] subunit alpha	ISS	21534948	PubMed	PTHR11117:SF11	SUCCINYL-COA LIGASE  ADP-FORMING  SUBUNIT ALPHA
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	ORNAN|Ensembl=ENSOANG00000003489|UniProtKB=F7FSE3	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00014	Cholesterol biosynthesis	P00494	Squalene monooxygenas	MACMU|Ensembl=ENSMMUG00000003535|UniProtKB=F7EXV9	Uncharacterized protein	ISS			PTHR10835:SF0	SQUALENE MONOOXYGENASE
P02728	Arginine biosynthesis	P02841	argininosuccinate lyase	MYCTU|EnsemblGenome=Rv1659|UniProtKB=P9WPY7	Argininosuccinate lyase	ISS			PTHR43814:SF1	ARGININOSUCCINATE LYASE
P02751	Lysine biosynthesis	P03011	N-succinyldiaminopimelate  aminotransferase	ECOLI|EcoGene=EG13999|UniProtKB=P77581	Succinylornithine transaminase	IDA	10074354	PubMed	PTHR11986:SF113	SUCCINYLORNITHINE TRANSAMINASE
P00021	FGF signaling pathway	P00648	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	BACSU|EnsemblGenome=BSU07350|UniProtKB=O06478	Putative aldehyde dehydrogenase YfmT	IC			PTHR42986:SF1	SUBFAMILY NOT NAMED
P00059	p53 pathway	P01486	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	PANTR|Ensembl=ENSPTRG00000000750|UniProtKB=H2PZ19	Uncharacterized protein	ISS	96032356	PubMed	PTHR11958:SF22	EXCITATORY AMINO ACID TRANSPORTER 5
P00010	B cell activation	P00402	Jnk	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00013	Cell cycle	P00481	APC	PANTR|Ensembl=ENSPTRG00000021597|UniProtKB=H2QY82	Uncharacterized protein	ISS	7019327	gi	PTHR11932:SF5	ANAPHASE-PROMOTING COMPLEX SUBUNIT 2
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02741	Flavin biosynthesis	P02935	GTP cyclohydrolase	ARATH|TAIR=AT5G59750|UniProtKB=Q9FN89	Monofunctional riboflavin biosynthesis protein RIBA 3, chloroplastic	ISS			PTHR21327:SF29	MONOFUNCTIONAL RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBA 3, CHLOROPLASTIC
P00020	FAS signaling pathway	P00600	PARP	CAEEL|WormBase=WBGene00004050|UniProtKB=Q09525	Poly(ADP-ribose) polymerase pme-2	TAS	12101391	PubMed	PTHR10459:SF60	POLY  ADP-RIBOSE  POLYMERASE 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01076	CAT	CAEEL|WormBase=WBGene00000481|UniProtKB=P32756	Choline O-acetyltransferase	ISS	92155737	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00702	CPB	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	RCA			PTHR13808:SF5	CREB-BINDING PROTEIN
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00054	Toll receptor signaling pathway	P01360	IKKbeta	HUMAN|HGNC=5960|UniProtKB=O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00057	Wnt signaling pathway	P01438	PP2A	CHICK|Ensembl=ENSGALG00000010273|UniProtKB=P48463	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	YEAST|SGD=S000003666|UniProtKB=P07259	Protein URA2	ISS			PTHR11405:SF5	CAD PROTEIN
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IDA	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00018	EGF receptor signaling pathway	P00556	PLCgamma	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P06959	CCKR signaling map	P07153	RSK1/2	HUMAN|HGNC=10432|UniProtKB=P51812	Ribosomal protein S6 kinase alpha-3	RCA	12239223	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P06959	CCKR signaling map	P07176	NFAT1	HUMAN|HGNC=7776|UniProtKB=Q13469	Nuclear factor of activated T-cells, cytoplasmic 2	RCA	17978097	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00047	PDGF signaling pathway	P01159	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00009	Axon guidance mediated by netrin	P00363	PI3K	MONDO|Ensembl=ENSMODG00000001583|UniProtKB=F7BBM1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00057	Wnt signaling pathway	P01457	GBeta	DAPPU|EnsemblGenome=DAPPUDRAFT_206575|UniProtKB=E9FUX0	Guanine nucleotide binding protein, beta subunit	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00034	Integrin signalling pathway	P00927	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00054	Toll receptor signaling pathway	P01352	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00036	Interleukin signaling pathway	P00973	PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00052	TGF-beta signaling pathway	P01286	TGFbeta	RAT|RGD=620743|UniProtKB=G3V6W8	Bone morphogenetic protein 7	ISS	9759503	PubMed	PTHR11848:SF135	BONE MORPHOGENETIC PROTEIN 7
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	RCA	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00049	Parkinson disease	P01227	20S proteasome	ARATH|TAIR=AT3G22110|UniProtKB=O81148	Proteasome subunit alpha type-4-A	TAS	12859888	PubMed	PTHR11599:SF13	PROTEASOME SUBUNIT ALPHA TYPE-4
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01181	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00037	Ionotropic glutamate receptor pathway	P01001	KA4	RAT|RGD=2734|UniProtKB=Q01812	Glutamate receptor ionotropic, kainate 4	IC	12941441	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	MOUSE|MGI=MGI=102522|UniProtKB=Q8R3Z5	Voltage-dependent L-type calcium channel subunit beta-1	IC	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00054	Toll receptor signaling pathway	P01380	TLR1,2,6	HUMAN|HGNC=11848|UniProtKB=O60603	Toll-like receptor 2	ISS			PTHR24365:SF17	TOLL-LIKE RECEPTOR 2
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	FUSNN|EnsemblGenome=FN0355|UniProtKB=Q8RGE5	S-adenosylmethionine synthase	ISS			PTHR11964:SF1	S-ADENOSYLMETHIONINE SYNTHASE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MACMU|Ensembl=ENSMMUG00000016675|UniProtKB=F6VTB5	Uncharacterized protein	ISS	11554549	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00048	PI3 kinase pathway	P01193	IRS	MACMU|Ensembl=ENSMMUG00000019467|UniProtKB=F6SUL3	Uncharacterized protein	ISS	1311924	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00021	FGF signaling pathway	P00642	MEK1-2	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	PANTR|Ensembl=ENSPTRG00000017182|UniProtKB=H2RAT8	Casein kinase 1, gamma 3	ISS	10617630	PubMed	PTHR11909:SF151	CASEIN KINASE I ISOFORM GAMMA-3
P00047	PDGF signaling pathway	P01152	RasGAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	2842690	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	MOUSE|MGI=MGI=99685|UniProtKB=E9Q401	Ryanodine receptor 2	ISS	15858232	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00021	FGF signaling pathway	P00629	PP2A	MOUSE|MGI=MGI=1321159|UniProtKB=P63330	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00226	Delta/Serrate	PANTR|Ensembl=ENSPTRG00000018824|UniProtKB=H2QU26	Delta-like protein	ISS			PTHR24044:SF380	DELTA-LIKE PROTEIN 1
P00005	Angiogenesis	P00203	Erk	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00645	Rac	ARATH|TAIR=AT2G17800|UniProtKB=Q38902	Rac-like GTP-binding protein ARAC1	ISS	12932731	PubMed	PTHR24072:SF179	RAC-LIKE GTP-BINDING PROTEIN ARAC1-RELATED
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	XENTR|Xenbase=XB-GENE-480347|UniProtKB=Q6P640	Actin, alpha cardiac muscle 1	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	BOVIN|Ensembl=ENSBTAG00000033153|UniProtKB=F1MG21	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	STRCO|Gene=CAB50991|UniProtKB=Q9S2H1	Putative cysteine synthase	ISS			PTHR10314:SF136	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01173	STAT	BOVIN|Gene=STAT5B|UniProtKB=Q9TUM3	Signal transducer and activator of transcription 5B	ISS	96102059	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IDA	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00005	Angiogenesis	P00220	c-Jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06732	ATF2	MOUSE|MGI=MGI=109349|UniProtKB=P16951	Cyclic AMP-dependent transcription factor ATF-2	RCA	7875593	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	IC	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00915	PTP-PEST	CANLF|Ensembl=ENSCAFG00000025333|UniProtKB=F1PZ23	Uncharacterized protein	ISS	8887669	PubMed	PTHR19134:SF283	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 12
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000022175|UniProtKB=F6XHY0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MONDO|Gene=KRAS|UniProtKB=Q07983	GTPase KRas	ISS	99084794	PubMed	PTHR24070:SF186	GTPASE KRAS
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	RCA	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IPI	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01407	Erk	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00049	Parkinson disease	P01227	20S proteasome	MACMU|Ensembl=ENSMMUG00000007358|UniProtKB=F7E9M5	Proteasome subunit beta type	ISS	12859888	PubMed	PTHR11599:SF42	PROTEASOME SUBUNIT BETA TYPE-7
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=107451|UniProtKB=Q8K2J0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3	ISS	12860966	PubMed	PTHR10336:SF33	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-3
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00049	Parkinson disease	P01227	20S proteasome	PANTR|Ensembl=ENSPTRG00000006390|UniProtKB=H2Q8D7	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF10	PROTEASOME SUBUNIT ALPHA TYPE-3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	TAS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00020	FAS signaling pathway	P00611	Gelsolin	PANTR|Ensembl=ENSPTRG00000021313|UniProtKB=H2QXT3	Gelsolin	ISS	9323209	PubMed	PTHR11977:SF29	GELSOLIN
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00019	Endothelin signaling pathway	P00585	ECE1-3	CAEEL|WormBase=WBGene00020293|UniProtKB=O16652	NEPrilysin metallopeptidase family	ISS			PTHR11733:SF7	NEPRILYSIN METALLOPEPTIDASE FAMILY
P00021	FGF signaling pathway	P00624	14-3-3	CHICK|Gene_ORFName=RCJMB04_1e8|UniProtKB=Q5ZMT0	14-3-3 protein epsilon	ISS	98119747	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P04393	Ras Pathway	P04569	Cdc42	ASHGO|EnsemblGenome=AGOS_AGL093W|UniProtKB=Q9HF56	Cell division control protein 42	ISS	11156982	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00036	Interleukin signaling pathway	P00962	ELK	CANLF|Ensembl=ENSCAFG00000006454|UniProtKB=E2QVW3	Uncharacterized protein	ISS			PTHR11849:SF172	ETS DOMAIN-CONTAINING PROTEIN ELK-3
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=101848|UniProtKB=P62881	Guanine nucleotide-binding protein subunit beta-5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00006	Apoptosis signaling pathway	P00322	Cytochrome C	YEAST|SGD=S000003809|UniProtKB=P00044	Cytochrome c iso-1	ISS			PTHR11961:SF12	CYTOCHROME C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	CANLF|Ensembl=ENSCAFG00000005606|UniProtKB=E2RE16	Uncharacterized protein	ISS			PTHR24361:SF345	SERINE/THREONINE-PROTEIN KINASE PAK 4
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00047	PDGF signaling pathway	P01174	Rho	MONDO|Ensembl=ENSMODG00000004712|UniProtKB=F6QGZ1	Uncharacterized protein	ISS			PTHR14166:SF8	SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 3
P00056	VEGF signaling pathway	P01407	Erk	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00059	p53 pathway	P04609	PI3K	CANAL|CGD=CAL0068551|UniProtKB=Q5AAR9	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CAEEL|WormBase=WBGene00022247|UniProtKB=V6CJ96	Ligand-Gated ion Channel	IC			PTHR18945:SF774	LIGAND-GATED ION CHANNEL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05913	Enkephalin release	P05974	G-Protein (i)	DROME|FlyBase=FBgn0001122|UniProtKB=P16378	G protein alpha o subunit	IC	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00047	PDGF signaling pathway	P01160	IP3 receptor	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P06959	CCKR signaling map	P07171	E-cadherin	HUMAN|HGNC=1748|UniProtKB=P12830	Cadherin-1	RCA	18515095	PubMed	PTHR24027:SF319	CADHERIN-1
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	MONDO|Ensembl=ENSMODG00000020977|UniProtKB=F6S5B1	Uncharacterized protein (Fragment)	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	BOVIN|Ensembl=ENSBTAG00000010191|UniProtKB=Q08E52	Serine/threonine-protein kinase PAK 1	ISS	14580336	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00046	Oxidative stress response	P01135	p38	CAEEL|WormBase=WBGene00004056|UniProtKB=Q8MXI4	Mitogen-activated protein kinase pmk-2	TAS	10514528	PubMed	PTHR24055:SF154	MITOGEN-ACTIVATED PROTEIN KINASE PMK-2
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	TAS	14526383	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	IC	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00887	IRS 1-4	BOVIN|Ensembl=ENSBTAG00000021308|UniProtKB=F1MYE0	Uncharacterized protein	ISS	15110093	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P04393	Ras Pathway	P04567	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00023	General transcription regulation	P00667	TFIIFbeta	MOUSE|MGI=MGI=1915955|UniProtKB=Q8R0A0	General transcription factor IIF subunit 2	ISS	92020241	PubMed	PTHR10445:SF0	GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04398	p53 pathway feedback loops 2	P04665	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12539654	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02747	Histidine biosynthesis	P02991	Histidinephosphate aminotransferase	METAC|EnsemblGenome=MA_0118|UniProtKB=Q8TUE9	Histidinol-phosphate aminotransferase	ISS			PTHR42885:SF2	HISTIDINOL-PHOSPHATE AMINOTRANSFERASE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00021	FGF signaling pathway	P00645	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	IPI	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00029	Huntington disease	P00807	Actin	CHICK|Ensembl=ENSGALG00000028749|UniProtKB=Q5ZMQ2	Actin, cytoplasmic 2	ISS	11889139	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00012	Cadherin signaling pathway	P00470	F-actin	XENTR|Xenbase=XB-GENE-491938|UniProtKB=Q6DIV8	Actin, alpha 1, skeletal muscle	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P06664	Gonadotropin-releasing hormone receptor pathway	G06675	Glut1	MOUSE|MGI=MGI=95755|UniProtKB=P17809	Solute carrier family 2, facilitated glucose transporter member 1	RCA			PTHR23503:SF51	SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 1
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01020	NSF	DROME|FlyBase=FBgn0000346|UniProtKB=P46461	Vesicle-fusing ATPase 1	ISS	7969419	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00011	Blood coagulation	P00423	APC	PANTR|Ensembl=ENSPTRG00000012428|UniProtKB=H2QIN8	Uncharacterized protein	ISS	4506115	gi	PTHR24278:SF0	VITAMIN K-DEPENDENT PROTEIN C
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	HUMAN|HGNC=784|UniProtKB=P15336	Cyclic AMP-dependent transcription factor ATF-2	TAS	10207617	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00056	VEGF signaling pathway	P01417	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00920	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00049	Parkinson disease	P01238	14-3-3	CAEEL|WormBase=WBGene00003920|UniProtKB=P41932	14-3-3-like protein 1	IDA	10407019	PubMed	PTHR18860:SF21	14-3-3-LIKE PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	HUMAN|HGNC=12338|UniProtKB=Q9Y210	Short transient receptor potential channel 6	IDA	11055438	PubMed	PTHR10117:SF7	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 6
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	IDA			PTHR13808:SF5	CREB-BINDING PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MONDO|Ensembl=ENSMODG00000015364|UniProtKB=F6WHM2	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	TAKRU|Ensembl=ENSTRUG00000000584|UniProtKB=H2RMN2	Uncharacterized protein	IDA	11248120	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00048	PI3 kinase pathway	P01188	Gbetagamma	CAEEL|WormBase=WBGene00001679|UniProtKB=P17343	Guanine nucleotide-binding protein subunit beta-1	IC	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008018|UniProtKB=F7EPG4	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00019	Endothelin signaling pathway	P00572	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	TAS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	DROME|FlyBase=FBgn0264000|UniProtKB=M9PHV5	Glutamate receptor IB, isoform B	IC	10331083	PubMed	PTHR18966:SF270	GLUTAMATE RECEPTOR 1-RELATED
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000012036|UniProtKB=F7ALP1	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00012	Cadherin signaling pathway	P00474	Wnt	RAT|RGD=69346|UniProtKB=G3V7U3	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P04393	Ras Pathway	P04568	MKK3/6	PANTR|Ensembl=ENSPTRG00000009588|UniProtKB=H2QZW5	Mitogen-activated protein kinase kinase 6	RCA			PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P00049	Parkinson disease	P01242	Casein kinase I	PLAF7|EnsemblGenome=PF11_0377|UniProtKB=Q8IHZ9	Casein kinase I	IDA	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	BOVIN|Ensembl=ENSBTAG00000003626|UniProtKB=F1MDE3	Uncharacterized protein	ISS			PTHR13140:SF311	MYOSIN-IIIB
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IC	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	DROME|FlyBase=FBgn0000150|UniProtKB=P08879	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00057	Wnt signaling pathway	P01438	PP2A	HUMAN|HGNC=9311|UniProtKB=Q13362	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	IDA	10092233	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00059	p53 pathway	P04633	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00023	General transcription regulation	P00668	TFIIB	BOVIN|Ensembl=ENSBTAG00000013874|UniProtKB=Q6B857	Cilia- and flagella-associated protein 20	ISS			PTHR12458:SF8	CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20
P00018	EGF receptor signaling pathway	P00539	14-3-3	ORNAN|Ensembl=ENSOANG00000007305|UniProtKB=F6XW91	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00052	TGF-beta signaling pathway	P01286	TGFbeta	ORNAN|Ensembl=ENSOANG00000010700|UniProtKB=F6SCP7	Uncharacterized protein	ISS	11451570	PubMed	PTHR11848:SF133	INHIBIN BETA A CHAIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05931	EGR	MOUSE|MGI=MGI=95295|UniProtKB=P08046	Early growth response protein 1	RCA			PTHR44685:SF1	EARLY GROWTH RESPONSE PROTEIN 1
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00049	Parkinson disease	P01228	DAT	MACMU|Ensembl=ENSMMUG00000005198|UniProtKB=Q7JHP9	Transporter	TAS	15135042	PubMed	PTHR11616:SF38	SODIUM-DEPENDENT DOPAMINE TRANSPORTER
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IDA	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	CAEEL|WormBase=WBGene00011283|UniProtKB=Q22033	Uncharacterized protein	IDA	11437445	PubMed	PTHR11909:SF19	ASATOR, ISOFORM D
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	TAS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00054	Toll receptor signaling pathway	P01354	NFkappaB	PANTR|Ensembl=ENSPTRG00000003889|UniProtKB=G2HHW9	Transcription factor p65	ISS	10049353	PubMed	PTHR24169:SF1	TRANSCRIPTION FACTOR P65
P02770	Pyridoxal phosphate salvage pathway	P03121	Pyridoxal kinase	ECOLI|EcoGene=EG12642|UniProtKB=P40191	Pyridoxine/pyridoxal/pyridoxamine kinase	ISS	11206551	PubMed	PTHR10534:SF13	PYRIDOXINE/PYRIDOXAL/PYRIDOXAMINE KINASE
P00019	Endothelin signaling pathway	P00568	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IGI	2837282	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PANTR|Ensembl=ENSPTRG00000006890|UniProtKB=H2Q943	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00048	PI3 kinase pathway	P01179	PKB	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	TAS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MACMU|Ensembl=ENSMMUG00000019112|UniProtKB=F6T8S6	N-methyl D-aspartate receptor subtype 2B	ISS	11554554	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P02771	Pyrimidine Metabolism	P03131	5'-Nucleotidase	RAT|RGD=61956|UniProtKB=P21588	5'-nucleotidase	RCA	8224905	PubMed	PTHR11575:SF25	5'-NUCLEOTIDASE
P00023	General transcription regulation	P00658	TBP-associated factors	MACMU|Ensembl=ENSMMUG00000012470|UniProtKB=F7G0B2	Uncharacterized protein	ISS	604904	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00057	Wnt signaling pathway	P01456	beta-arrestin	PANTR|Ensembl=ENSPTRG00000021993|UniProtKB=H2QYR2	Uncharacterized protein	ISS	11742073	PubMed	PTHR11792:SF19	ARRESTIN-C
P00048	PI3 kinase pathway	P01185	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	PANTR|Ensembl=ENSPTRG00000004718|UniProtKB=H2Q5I0	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00021	FGF signaling pathway	P00639	Shc	DROME|FlyBase=FBgn0015296|UniProtKB=Q9V3C8	DShc protein	ISS	8491186	PubMed	PTHR10337:SF11	DSHC PROTEIN
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	METAC|EnsemblGenome=MA_3169|UniProtKB=Q8TL71	Glutamate dehydrogenase	ISS			PTHR11606:SF13	GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	BOVIN|Ensembl=ENSBTAG00000023730|UniProtKB=Q2T9S0	Tubulin beta-3 chain	ISS	12932731	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P06664	Gonadotropin-releasing hormone receptor pathway	P06831	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	RCA	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00059	p53 pathway	P04630	PP2A	XENTR|Xenbase=XB-GENE-484003|UniProtKB=Q6P365	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01140	ELK	MACMU|Ensembl=ENSMMUG00000001024|UniProtKB=F6XTS0	ETS domain-containing protein Elk-4 isoform a	ISS	11846562	PubMed	PTHR11849:SF21	ETS DOMAIN-CONTAINING PROTEIN ELK-4
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01422	eNOS	CANLF|Gene=NOS3|UniProtKB=Q9TUX8	Nitric oxide synthase, endothelial	ISS	93055452	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	TAS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04542	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	G01581	BAX	MOUSE|MGI=MGI=99702|UniProtKB=Q07813	Apoptosis regulator BAX	IGI	8358790	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P00012	Cadherin signaling pathway	P00475	Frizzled	BOVIN|Ensembl=ENSBTAG00000002283|UniProtKB=F1N4K7	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF31	FRIZZLED-7
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	HUMAN|HGNC=11772|UniProtKB=P36897	TGF-beta receptor type-1	TAS	9395284	PubMed	PTHR23255:SF61	TGF-BETA RECEPTOR TYPE-1
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00034	Integrin signalling pathway	P00949	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95817|UniProtKB=Q8BMF5	Glutamate receptor ionotropic, kainate 4	ISS	12941441	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ANOGA|EnsemblGenome=AGAP005911|UniProtKB=Q7Q6D4	AGAP005911-PA	IC	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P06959	CCKR signaling map	P07100	Dynamin	HUMAN|HGNC=2972|UniProtKB=Q05193	Dynamin-1	RCA	18184106	PubMed	PTHR11566:SF32	DYNAMIN-1
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	RCA	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P06959	CCKR signaling map	G07283	MOB1	HUMAN|HGNC=16015|UniProtKB=Q9H8S9	MOB kinase activator 1A	RCA	10409110	PubMed	PTHR22599:SF30	MOB KINASE ACTIVATOR 1A
P04398	p53 pathway feedback loops 2	P04669	ATM	BOVIN|Ensembl=ENSBTAG00000003111|UniProtKB=E1BEI6	Uncharacterized protein	ISS	10196661	PubMed	PTHR11139:SF72	SERINE-PROTEIN KINASE ATM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	CANLF|Ensembl=ENSCAFG00000009812|UniProtKB=E2RIA0	Uncharacterized protein	ISS			PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00009	Axon guidance mediated by netrin	P00356	UNC-5	PANTR|Ensembl=ENSPTRG00000020154|UniProtKB=H2R9V2	Uncharacterized protein	ISS			PTHR12582:SF5	NETRIN RECEPTOR UNC5D
P00005	Angiogenesis	P00243	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00012	Cadherin signaling pathway	P00470	F-actin	HUMAN|HGNC=144|UniProtKB=P63261	Actin, cytoplasmic 2	IC	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	CANLF|Gene=DRD2|UniProtKB=Q9GJU1	D(2) dopamine receptor	ISS	1319557	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MACMU|Ensembl=ENSMMUG00000010392|UniProtKB=F7ASR8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	PANTR|Ensembl=ENSPTRG00000014760|UniProtKB=H2QMB3	Serine/threonine-protein kinase receptor	ISS	9395284	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P00009	Axon guidance mediated by netrin	P00364	cdc42	ASHGO|EnsemblGenome=AGOS_AGL093W|UniProtKB=Q9HF56	Cell division control protein 42	ISS	11156982	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	TAS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00054	Toll receptor signaling pathway	P01365	TAB1	MOUSE|MGI=MGI=1913763|UniProtKB=Q8CF89	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1	ISS	8638164	PubMed	PTHR13832:SF533	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06834	MAP3Ks	MOUSE|MGI=MGI=1346876|UniProtKB=O35099	Mitogen-activated protein kinase kinase kinase 5	RCA	12697749	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P06213	DPP signaling pathway	P06285	DPP	DROME|FlyBase=FBgn0000490|UniProtKB=P07713	Protein decapentaplegic	IEA	9759503	PubMed	PTHR11848:SF234	PROTEIN DECAPENTAPLEGIC
P00048	PI3 kinase pathway	P01181	GSK3	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CAEBR|Gene=CBG23195|UniProtKB=A8Y4H0	Protein CBR-DES-2	ISS			PTHR18945:SF410	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-TYPE DES-2
P05917	Opioid proopiomelanocortin pathway	P06007	alpha-MSH	PANTR|Ensembl=ENSPTRG00000011721|UniProtKB=H2R8Y3	Uncharacterized protein	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00018	EGF receptor signaling pathway	P00555	MKK4,7	MOUSE|MGI=MGI=1346869|UniProtKB=P47809	Dual specificity mitogen-activated protein kinase kinase 4	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IDA	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00021	FGF signaling pathway	P00629	PP2A	DROME|FlyBase=FBgn0003139|UniProtKB=Q27884	Serine/threonine-protein phosphatase 6 catalytic subunit	ISS			PTHR11668:SF24	SERINE/THREONINE-PROTEIN PHOSPHATASE 6 CATALYTIC SUBUNIT
P00018	EGF receptor signaling pathway	P00555	MKK4,7	XENTR|Xenbase=XB-GENE-487078|UniProtKB=Q4QQQ5	Mitogen-activated protein kinase kinase 7	ISS			PTHR24361:SF387	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7
P02727	Androgen/estrogene/progesterone biosynthesis	P02828	Aromatase	HUMAN|HGNC=2594|UniProtKB=P11511	Aromatase	RCA			PTHR24291:SF43	AROMATASE
P00019	Endothelin signaling pathway	P00568	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04375	5HT3 type receptor mediated signaling pathway	P04422	5HT3 Rec	MACMU|Ensembl=ENSMMUG00000007079|UniProtKB=F7ESG7	Uncharacterized protein	ISS	7509203	PubMed	PTHR18945:SF53	5-HYDROXYTRYPTAMINE RECEPTOR 3B
P06959	CCKR signaling map	G06979	MYC	HUMAN|HGNC=7553|UniProtKB=P01106	Myc proto-oncogene protein	RCA	17167838	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	BOVIN|Ensembl=ENSBTAG00000007882|UniProtKB=G3X7Z2	Uncharacterized protein	ISS	15079861	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	XENTR|Xenbase=XB-GENE-5733929|UniProtKB=Q6P647	Casein kinase I isoform delta	ISS	11437445	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	MACMU|Ensembl=ENSMMUG00000010173|UniProtKB=F7AGU8	Presenilin	ISS	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P00017	DNA replication	P00527	Histones	MACMU|Ensembl=ENSMMUG00000031506|UniProtKB=F7GHH9	Histone H3	ISS	20448842	PubMed	PTHR11426:SF184	HISTONE H3.1T
P00018	EGF receptor signaling pathway	P00543	ERK1-2	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	IGI	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00005	Angiogenesis	P00217	STAT3	BOVIN|Gene=STAT3|UniProtKB=P61635	Signal transducer and activator of transcription 3	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	IDA	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04393	Ras Pathway	P04542	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04558	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00057	Wnt signaling pathway	P01465	Ggamma	CANLF|Ensembl=ENSCAFG00000028654|UniProtKB=J9P702	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DANRE|ZFIN=ZDB-GENE-050417-267|UniProtKB=F1QUN8	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF263	ACTIN
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00059	p53 pathway	P04630	PP2A	IXOSC|EnsemblGenome=ISCW014549|UniProtKB=B7QGY5	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P06587	Nicotine pharmacodynamics pathway	P06612	CHRNB3	PANTR|Gene=CHRNB3|UniProtKB=Q5IS75	Neuronal acetylcholine receptor subunit beta-3	ISS	15155845	PubMed	PTHR18945:SF75	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-3
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06707	FAK	MOUSE|MGI=MGI=95481|UniProtKB=P34152	Focal adhesion kinase 1	RCA	12640026	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P04393	Ras Pathway	P04543	MEKK1/4	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	IDA	11730323	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00117	E-cadherin C-terminal fragment	HUMAN|HGNC=1762|UniProtKB=P22223	Cadherin-3	IDA	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P00036	Interleukin signaling pathway	P00981	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00021	FGF signaling pathway	P00648	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	11591316	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00005	Angiogenesis	P00205	GAP	HUMAN|HGNC=9871|UniProtKB=P20936	Ras GTPase-activating protein 1	IDA	11847220	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04393	Ras Pathway	P04579	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	8264585	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	RAT|RGD=621375|UniProtKB=Q9QY78	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00047	PDGF signaling pathway	P01165	SRF	PANTR|Ensembl=ENSPTRG00000018189|UniProtKB=H2QT21	Uncharacterized protein	ISS	15647354	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00021	FGF signaling pathway	P00648	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00005	Angiogenesis	P00194	Paxillin	CANLF|Ensembl=ENSCAFG00000016896|UniProtKB=E2RTE0	Uncharacterized protein	ISS			PTHR24216:SF27	TRANSFORMING GROWTH FACTOR BETA-1-INDUCED TRANSCRIPT 1 PROTEIN
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00002	Alpha adrenergic receptor signaling pathway	P00078	Alpha1A/1B/1C	MOUSE|MGI=MGI=106673|UniProtKB=P97714	Alpha-1D adrenergic receptor	IC	11781138	PubMed	PTHR24248:SF14	ALPHA-1D ADRENERGIC RECEPTOR
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00925	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00006	Apoptosis signaling pathway	P00272	ASK1	PANTR|Ensembl=ENSPTRG00000024326|UniProtKB=H2R231	Uncharacterized protein	ISS	8974401	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	MOUSE|MGI=MGI=87889|UniProtKB=Q2MKA5	Neuronal acetylcholine receptor subunit alpha-5	ISS	12388584	PubMed	PTHR18945:SF76	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5
P00018	EGF receptor signaling pathway	P00540	MKK3,6	MACMU|Ensembl=ENSMMUG00000010904|UniProtKB=F7GLY5	Uncharacterized protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P06959	CCKR signaling map	G07294	TAC1	HUMAN|HGNC=11517|UniProtKB=P20366	Protachykinin-1	RCA	20007404	PubMed	PTHR11250:SF3	PROTACHYKININ-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	RAT|RGD=620537|UniProtKB=O55197	C3a anaphylatoxin chemotactic receptor	IDA	12421977	PubMed	PTHR24225:SF28	C3A ANAPHYLATOXIN CHEMOTACTIC RECEPTOR
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	IC	9199552	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00059	p53 pathway	P04609	PI3K	RAT|RGD=1310389|UniProtKB=D3ZTF6	Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Predicted), isoform CRA_a	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00021	FGF signaling pathway	P00647	SHP2	RAT|RGD=3447|UniProtKB=P41499	Tyrosine-protein phosphatase non-receptor type 11	IGI	14525967	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00476	Yes	RAT|RGD=621017|UniProtKB=Q07014	Tyrosine-protein kinase Lyn	ISS			PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01163	c-Jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00021	FGF signaling pathway	P00640	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	MOUSE|MGI=MGI=94925|UniProtKB=P30728	D(3) dopamine receptor	ISS	1319557	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	RCA			PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P02759	Pyridoxal-5-phosphate biosynthesis	P03062	1-Deoxyxylulose-5-phosphate synthase	AQUAE|EnsemblGenome=aq_881|UniProtKB=O67036	1-deoxy-D-xylulose-5-phosphate synthase	ISS			PTHR43322:SF6	1-DEOXY-D-XYLULOSE-5-PHOSPHATE SYNTHASE
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00023	General transcription regulation	P00658	TBP-associated factors	RAT|RGD=621116|UniProtKB=Q62880	Transcription initiation factor TFIID subunit 9B	ISS			PTHR12595:SF3	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 9B
P00036	Interleukin signaling pathway	P00976	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00019	Endothelin signaling pathway	P00584	Gs	CHICK|Ensembl=ENSGALG00000007509|UniProtKB=F1NM72	Uncharacterized protein	ISS	87005246	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00006	Apoptosis signaling pathway	P00274	JNK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	ISS	10851062	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00564	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	91298951	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01154	Ras	MOUSE|MGI=MGI=99425|UniProtKB=P46638	Ras-related protein Rab-11B	ISS			PTHR24073:SF335	RAS-RELATED PROTEIN RAB-11B
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	CHICK|Ensembl=ENSGALG00000014033|UniProtKB=E1BTS2	Uncharacterized protein	ISS	9869449	PubMed	PTHR24070:SF186	GTPASE KRAS
P05913	Enkephalin release	P05974	G-Protein (i)	DICDI|dictyBase=DDB_G0277143|UniProtKB=P36408	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00052	TGF-beta signaling pathway	P01286	TGFbeta	RAT|RGD=2913|UniProtKB=P17491	Inhibin beta B chain	TAS	11451570	PubMed	PTHR11848:SF29	INHIBIN BETA B CHAIN
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=14546|UniProtKB=Q9NRJ7	Protocadherin beta-16	IDA	8120095	PubMed	PTHR24028:SF71	PROTOCADHERIN BETA-16
P02785	Valine biosynthesis	P03218	Dihydroxy isovalerate dehydratase	STRCO|Gene=CAB46389|UniProtKB=Q9X9Y4	Putative dihydroxy-acid dehydratase	ISS			PTHR43183:SF2	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00056	VEGF signaling pathway	P01408	Akt/PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00048	PI3 kinase pathway	P01179	PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	HUMAN|HGNC=4588|UniProtKB=O15399	Glutamate receptor ionotropic, NMDA 2D	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00019	Endothelin signaling pathway	P00585	ECE1-3	PANTR|Ensembl=ENSPTRG00000000298|UniProtKB=H2R1S0	Endothelin converting enzyme 1	ISS	8034569	PubMed	PTHR11733:SF130	ENDOTHELIN-CONVERTING ENZYME 1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	IDA	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00029	Huntington disease	P00780	Microtubule	SCHMA|EnsemblGenome=Smp_030730|UniProtKB=G4LW34	Tubulin beta chain,putative	ISS	12932731	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	TAS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=98327|UniProtKB=P30873	Somatostatin receptor type 1	IDA	12562507	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01093	AChE	BOVIN|Ensembl=ENSBTAG00000011139|UniProtKB=P32749	Cholinesterase	ISS	86008285	PubMed	PTHR43918:SF5	CHOLINESTERASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00206	Wnt	MOUSE|MGI=MGI=108061|UniProtKB=P48614	Protein Wnt-10b	ISS	11266476	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00021	FGF signaling pathway	P00635	FRS2	BOVIN|Ensembl=ENSBTAG00000019155|UniProtKB=E1B7I9	Uncharacterized protein	ISS	12571252	PubMed	PTHR21258:SF40	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2
P00005	Angiogenesis	P00208	MEKK1	BOVIN|Ensembl=ENSBTAG00000013790|UniProtKB=E1B847	Uncharacterized protein	ISS	12168099	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02755	Methylmalonyl pathway	P03033	Propionyl-CoA carboxylase	STRCO|Gene=CAD30916|UniProtKB=Q7AKI7	Propionyl-CoA carboxylase complex B subunit	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P00018	EGF receptor signaling pathway	P00552	Ras	MONDO|Gene=KRAS|UniProtKB=Q07983	GTPase KRas	ISS	3023884	PubMed	PTHR24070:SF186	GTPASE KRAS
P04398	p53 pathway feedback loops 2	G04711	SIAH-1	MOUSE|MGI=MGI=108064|UniProtKB=P61092	E3 ubiquitin-protein ligase SIAH1A	IDA	11389839	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00034	Integrin signalling pathway	P00906	Rap1	XENTR|Xenbase=XB-GENE-5801166|UniProtKB=F6ZE26	Uncharacterized protein	ISS	8576107	PubMed	PTHR24070:SF382	RAS-RELATED PROTEIN RAP-1B
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000033526|UniProtKB=E1B8Q3	Guanine nucleotide binding protein 13, gamma-like	ISS	10391901	PubMed	PTHR15936:SF2	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-13
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT1G10210|UniProtKB=Q39021	Mitogen-activated protein kinase 1	ISS	11707292	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00747	Rhodopsin	MACMU|Ensembl=ENSMMUG00000012734|UniProtKB=F7ETG0	Rhodopsin	ISS	1634520	PubMed	PTHR24240:SF15	RHODOPSIN
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8688|UniProtKB=Q9Y5E6	Protocadherin beta-3	IDA	8120095	PubMed	PTHR24028:SF118	PROTOCADHERIN BETA-3
P00053	T cell activation	P01337	B7	BOVIN|Ensembl=ENSBTAG00000013118|UniProtKB=Q1JPC5	CD86 antigen	IDA	7694363	PubMed	PTHR25466:SF2	T-LYMPHOCYTE ACTIVATION ANTIGEN CD86
P00049	Parkinson disease	P01211	ERK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DANRE|ZFIN=ZDB-GENE-010705-1|UniProtKB=Q90Z40	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00049	Parkinson disease	P01223	UbcH8	DROME|FlyBase=FBgn0017456|UniProtKB=P52487	Ubiquitin-conjugating enzyme E2-18 kDa	IDA			PTHR24068:SF116	AT26201P-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	DROME|FlyBase=FBgn0001123|UniProtKB=P20354	G protein alpha s subunit	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00034	Integrin signalling pathway	P00922	Collagen	HUMAN|HGNC=2201|UniProtKB=P02461	Collagen alpha-1(III) chain	IDA	10778855	PubMed	PTHR24023:SF604	COLLAGEN ALPHA-1 III  CHAIN
P00054	Toll receptor signaling pathway	P01369	MKK1	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ARATH|TAIR=AT5G64760|UniProtKB=Q8VWK0	26S proteasome non-ATPase regulatory subunit 12 homolog B	ISS			PTHR10855:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00034	Integrin signalling pathway	P00925	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00048	PI3 kinase pathway	P01199	Galpha	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	IC	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00017	DNA replication	P00538	RNase H	PSEAE|EnsemblGenome=PA1815|UniProtKB=Q9I2S9	Ribonuclease HI	ISS	20437337	PubMed	PTHR10642:SF0	RIBONUCLEASE H1
P00059	p53 pathway	G04694	p110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00057	Wnt signaling pathway	P01465	Ggamma	CANLF|Ensembl=ENSCAFG00000019608|UniProtKB=E2R7K4	Uncharacterized protein	ISS	10391901	PubMed	PTHR15936:SF2	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-13
P00025	Hedgehog signaling pathway	P00682	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	8787761	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04558	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00012	Cadherin signaling pathway	P00475	Frizzled	HUMAN|HGNC=4038|UniProtKB=Q9UP38	Frizzled-1	IDA	8717036	PubMed	PTHR11309:SF81	FRIZZLED-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P02760	PRPP biosynthesis	P03064	Phosphopentose mutase	BACSU|EnsemblGenome=BSU23500|UniProtKB=P46353	Phosphopentomutase	ISS			PTHR21110:SF0	PHOSPHOPENTOMUTASE
P00005	Angiogenesis	P00219	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000009907|UniProtKB=F1MVV5	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF25	MITOGEN-ACTIVATED PROTEIN KINASE 4
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	BACSU|EnsemblGenome=BSU17680|UniProtKB=P0CI79	Thymidylate synthase 1	ISS			PTHR11548:SF1	SUBFAMILY NOT NAMED
P00009	Axon guidance mediated by netrin	P00363	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	ISS	14526383	PubMed	PTHR10048:SF14	PI-3 KINASE
P00035	Interferon-gamma signaling pathway	P00954	Interferongamma	MOUSE|MGI=MGI=107656|UniProtKB=P01580	Interferon gamma	TAS	11929133	PubMed	PTHR11419:SF0	INTERFERON GAMMA
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02746	Heme biosynthesis	P02980	Coproporphyrinogen Oxidase (oxygen dependent)	MACMU|Ensembl=ENSMMUG00000010833|UniProtKB=F7GNW9	Uncharacterized protein	ISS			PTHR10755:SF0	OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL
P00036	Interleukin signaling pathway	P00990	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04558	p38	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	IDA	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00006	Apoptosis signaling pathway	P00310	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04651	Ras	XENTR|Xenbase=XB-GENE-6085898|UniProtKB=F6WDS0	Uncharacterized protein	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00005	Angiogenesis	P00206	Wnt	PANTR|Ensembl=ENSPTRG00000015034|UniProtKB=H2QMT4	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P04393	Ras Pathway	P04547	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P05915	Opioid proenkephalin pathway	P05994	G-protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	ISS	15860573	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P04393	Ras Pathway	P04570	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IDA	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00049	Parkinson disease	P01227	20S proteasome	ORYSJ|EnsemblGenome=OS09G0538200|UniProtKB=Q0J006	Proteasome subunit alpha type-7-B	ISS	12859888	PubMed	PTHR11599:SF15	PROTEASOME SUBUNIT ALPHA TYPE
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=14268|UniProtKB=Q9HCL0	Protocadherin-18	ISS	8120095	PubMed	PTHR24028:SF9	PROTOCADHERIN-18
P00019	Endothelin signaling pathway	P00568	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00034	Integrin signalling pathway	P00906	Rap1	BOVIN|Ensembl=ENSBTAG00000020412|UniProtKB=E1BNQ3	Uncharacterized protein	ISS	8576107	PubMed	PTHR24070:SF221	RAS-RELATED PROTEIN RAP-2A
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P06664	Gonadotropin-releasing hormone receptor pathway	P06834	MAP3Ks	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	RCA	12168099	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	BOVIN|Ensembl=ENSBTAG00000016198|UniProtKB=E1B8D6	Uncharacterized protein	ISS			PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00029	Huntington disease	P00786	ARF	IXOSC|EnsemblGenome=ISCW022927|UniProtKB=B7QCW2	ADP-ribosylation factor	ISS	12932731	PubMed	PTHR11711:SF304	ADP-RIBOSYLATION FACTOR 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00006	Apoptosis signaling pathway	P00264	c-IAP1,2	HUMAN|HGNC=590|UniProtKB=Q13490	Baculoviral IAP repeat-containing protein 2	ISS			PTHR10044:SF79	BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 2
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00049	Parkinson disease	P01227	20S proteasome	SCHPO|PomBase=SPAC6G10.04c|UniProtKB=O14250	Probable proteasome subunit alpha type-6	TAS	12859888	PubMed	PTHR11599:SF12	PROTEASOME SUBUNIT ALPHA TYPE-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IC	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00057	Wnt signaling pathway	P01427	Naked	BOVIN|Ensembl=ENSBTAG00000012295|UniProtKB=A7Z042	NKD1 protein	ISS	11356022	PubMed	PTHR22611:SF2	PROTEIN NAKED CUTICLE HOMOLOG 1
P00057	Wnt signaling pathway	P01438	PP2A	DANRE|ZFIN=ZDB-GENE-040426-2487|UniProtKB=Q803G3	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00046	Oxidative stress response	P01135	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	TAS	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00012	Cadherin signaling pathway	P00470	F-actin	ARATH|TAIR=AT5G09810|UniProtKB=P53492	Actin-7	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00047	PDGF signaling pathway	P01162	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01179	PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	HUMAN|HGNC=5467|UniProtKB=P11717	Cation-independent mannose-6-phosphate receptor	TAS	6382022	PubMed	PTHR15071:SF17	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01321	SLP-76	RAT|RGD=619743|UniProtKB=Q920L0	Lymphocyte cytosolic protein 2	IGI	9665884	PubMed	PTHR14098:SF1	LYMPHOCYTE CYTOSOLIC PROTEIN 2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ASHGO|EnsemblGenome=AGOS_ABR222W|UniProtKB=Q75D00	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00048	PI3 kinase pathway	P01202	p85	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P06587	Nicotine pharmacodynamics pathway	P06613	CHRNB2	MACMU|Ensembl=ENSMMUG00000016089|UniProtKB=F7GMZ4	Neuronal acetylcholine receptor subunit beta-2	ISS	15155845	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P04393	Ras Pathway	P04556	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	IDA	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	DROME|FlyBase=FBgn0003887|UniProtKB=Q24560	Tubulin beta-1 chain	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01320	PLC-gamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00021	FGF signaling pathway	P00640	PI3K	DROME|FlyBase=FBgn0015278|UniProtKB=Q7K3H0	LD28067p	IGI	7937853	PubMed	PTHR10048:SF64	LD28067P
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IDA	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00006	Apoptosis signaling pathway	P00260	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IDA	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04556	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00034	Integrin signalling pathway	P00947	Laminin	MACMU|Ensembl=ENSMMUG00000002952|UniProtKB=F7GZQ3	Laminin subunit beta-2	ISS	2538453	PubMed	PTHR10574:SF36	LAMININ SUBUNIT BETA-2
P00047	PDGF signaling pathway	P01149	MNK1/2	BOVIN|Ensembl=ENSBTAG00000018049|UniProtKB=E1BCH7	Uncharacterized protein	ISS	9155017	PubMed	PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	IC	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	ISS	9199552	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	ORNAN|Ensembl=ENSOANG00000004342|UniProtKB=F6S3B9	Uncharacterized protein	ISS	12441358	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	ANOGA|EnsemblGenome=AGAP001478|UniProtKB=Q7PXM3	AGAP001478-PA	IC	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	RAT|RGD=3139|UniProtKB=Q29RW1	Myosin-4	ISS	89264452	PubMed	PTHR13140:SF657	MYOSIN-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	TAKRU|Ensembl=ENSTRUG00000011655|UniProtKB=H2TXP5	Uncharacterized protein	ISS	11430913	PubMed	PTHR23122:SF40	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P00045	Notch signaling pathway	P01113	Pen-2	MOUSE|MGI=MGI=109284|UniProtKB=Q61144	Presenilin-2	IGI	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	CHICK|Ensembl=ENSGALG00000009320|UniProtKB=Q4JIM4	Presenilin-1	TAS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00644	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IGI	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	IC	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05913	Enkephalin release	P05977	G-Protein (s)	XENTR|Xenbase=XB-GENE-977853|UniProtKB=F7EBE7	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00053	T cell activation	P01300	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	ARATH|TAIR=AT5G62690|UniProtKB=Q56YW9	Tubulin beta-2 chain	ISS	9454836	PubMed	PTHR11588:SF259	TUBULIN BETA-2 CHAIN-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DICPU|Gene=DICPUDRAFT_92985|UniProtKB=F1A084	Putative uncharacterized protein rac1A	ISS	12932731	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P02738	De novo purine biosynthesis	P02892	5-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase	SCHPO|PomBase=SPBC14F5.09c|UniProtKB=O60105	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P00059	p53 pathway	G04694	p110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CAEBR|Gene=CBG02401|UniProtKB=A8WUE7	Protein CBR-NMR-1	ISS	11554554	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P02723	Adenine and hypoxanthine salvage pathway	P02804	Hypoxanthine phosphoribosyl transferase	DANRE|ZFIN=ZDB-GENE-040426-1918|UniProtKB=Q7ZV49	Hprt1 protein	ISS			PTHR43340:SF6	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02748	Isoleucine biosynthesis	P02996	Ketol-acid reductoisomerase	NEUCR|EnsemblGenome=EFNCRG00000003422|UniProtKB=P38674	Ketol-acid reductoisomerase, mitochondrial	ISS			PTHR21371:SF13	KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL
P02783	Tryptophan biosynthesis	P03208	Tryptophan synthase B	SULSO|EnsemblGenome=SSO1145|UniProtKB=Q97TX6	Tryptophan synthase beta chain 2	ISS			PTHR43565:SF1	TRYPTOPHAN SYNTHASE BETA CHAIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF330	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	HUMAN|HGNC=5299|UniProtKB=Q13639	5-hydroxytryptamine receptor 4	IDA	12181435	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P00009	Axon guidance mediated by netrin	P00364	cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00021	FGF signaling pathway	P00633	Ras	YEAST|SGD=S000005627|UniProtKB=P01119	Ras-like protein 1	ISS	7997267	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04665	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00023	General transcription regulation	P00658	TBP-associated factors	ARATH|TAIR=AT5G15570|UniProtKB=Q9LF25	Bromodomain transcription factor	ISS	604903	OMIM	PTHR12321:SF53	BROMODOMAIN TRANSCRIPTION FACTOR
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	ISS	14698601	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04372	5-Hydroxytryptamine degredation	P04401	Monoamine Oxidase	MOUSE|MGI=MGI=96916|UniProtKB=Q8BW75	Amine oxidase [flavin-containing] B	ISS	90344230	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00010	B cell activation	P00385	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05913	Enkephalin release	P05973	GPCR (i)	DANRE|ZFIN=ZDB-GENE-990415-199|UniProtKB=A3QJX7	Uncharacterized protein	ISS	11259487	PubMed	PTHR24229:SF74	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00631	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8235613	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	PANTR|Ensembl=ENSPTRG00000012501|UniProtKB=P61072	C-X-C chemokine receptor type 4	ISS	11591799	PubMed	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	TAS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MACMU|Ensembl=ENSMMUG00000029059|UniProtKB=F6QAX2	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00520	Rho GAPs	MOUSE|MGI=MGI=1924714|UniProtKB=Q812A5	Proline-rich protein 5	ISS			PTHR32428:SF4	PROLINE-RICH PROTEIN 5
P04393	Ras Pathway	P04570	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01199	Galpha	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	IC	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	XENTR|Xenbase=XB-GENE-1014077|UniProtKB=F6TKJ2	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IDA	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	HUMAN|HGNC=130|UniProtKB=P62736	Actin, aortic smooth muscle	IC	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=23112|UniProtKB=Q8TDW7	Protocadherin Fat 3	ISS	8120095	PubMed	PTHR24026:SF49	PROTOCADHERIN FAT 3
P00047	PDGF signaling pathway	P01140	ELK	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	ISS	11279280	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=95779|UniProtKB=P50149	Guanine nucleotide-binding protein G(t) subunit alpha-2	ISS	10188796	PubMed	PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P00049	Parkinson disease	P01211	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02781	Threonine biosynthesis	P03191	Homoserine kinase	ECOLI|EcoGene=EG10999|UniProtKB=P00547	Homoserine kinase	ISS			PTHR20861:SF1	HOMOSERINE KINASE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MACMU|Ensembl=ENSMMUG00000007765|UniProtKB=F7CW57	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00005	Angiogenesis	P00220	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MOUSE|MGI=MGI=1933206|UniProtKB=A2AIR5	Protein Grin3a	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MOUSE|MGI=MGI=1927343|UniProtKB=Q9Z1M4	Ribosomal protein S6 kinase beta-2	ISS	6755374	gi	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00036	Interleukin signaling pathway	P00965	ERK	MACMU|Ensembl=ENSMMUG00000008536|UniProtKB=F6WBZ5	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04397	p53 pathway by glucose deprivation	P04641	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04393	Ras Pathway	P04564	MAPKAP	RAT|RGD=1304980|UniProtKB=Q66H84	MAP kinase-activated protein kinase 3	IDA	11157753	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00053	T cell activation	P01332	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00470	F-actin	ORYSJ|EnsemblGenome=OS03G0836000|UniProtKB=Q10AZ4	Actin-3	IC	10974003	PubMed	PTHR11937:SF254	ACTIN-1-RELATED
P00006	Apoptosis signaling pathway	P00274	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00054	Toll receptor signaling pathway	P01358	ERK1	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	MACMU|Ensembl=ENSMMUG00000012305|UniProtKB=F7DLC9	Tyrosine-protein kinase receptor	ISS	249616	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	SCLS1|Gene=SS1G_08733|UniProtKB=A7ETS6	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00023	General transcription regulation	P00667	TFIIFbeta	SCHPO|PomBase=SPBC1198.13c|UniProtKB=O94424	Transcription initiation factor IIF subunit beta	ISS			PTHR10445:SF0	GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00029	Huntington disease	P00807	Actin	BOVIN|Ensembl=ENSBTAG00000005714|UniProtKB=Q3ZC07	Actin, alpha cardiac muscle 1	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g234494|UniProtKB=A7RU31	Predicted protein	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00005	Angiogenesis	P00223	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00819	AKT	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	MACMU|Ensembl=ENSMMUG00000022936|UniProtKB=F6U709	Uncharacterized protein	ISS	11248120	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00021	FGF signaling pathway	P00648	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00018	EGF receptor signaling pathway	P00547	PP2A	PANTR|Ensembl=ENSPTRG00000017238|UniProtKB=H2QRH7	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	BOVIN|Ensembl=ENSBTAG00000011723|UniProtKB=E1BKL6	Uncharacterized protein	ISS	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00059	p53 pathway	G04699	BAI-1	CHICK|Ensembl=ENSGALG00000016176|UniProtKB=E1BZ18	Uncharacterized protein	ISS			PTHR12011:SF40	ADHESION G PROTEIN-COUPLED RECEPTOR B3
P05913	Enkephalin release	P05972	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	MOUSE|MGI=MGI=105083|UniProtKB=P51906	Excitatory amino acid transporter 3	ISS	96032356	PubMed	PTHR11958:SF69	EXCITATORY AMINO ACID TRANSPORTER 3
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	BOVIN|Ensembl=ENSBTAG00000014113|UniProtKB=Q09141	C-C motif chemokine 8	ISS			PTHR12015:SF144	C-C MOTIF CHEMOKINE 8
P00036	Interleukin signaling pathway	P00965	ERK	MACMU|Ensembl=ENSMMUG00000008536|UniProtKB=F6WBZ5	Mitogen-activated protein kinase	ISS	12912994	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P02747	Histidine biosynthesis	P02989	Phosphoribosyl AMP cyclohydrolase	GLOVI|EnsemblGenome=BAC89152|UniProtKB=Q7NLB5	Histidine biosynthesis bifunctional protein HisIE	ISS			PTHR42945:SF1	HISTIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN HISIE, CHLOROPLASTIC
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04558	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00054	Toll receptor signaling pathway	P01375	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00052	TGF-beta signaling pathway	P01284	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	TAS	10851062	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000010521|UniProtKB=F7DQK7	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P04398	p53 pathway feedback loops 2	P04665	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01298	NFkappaB	HUMAN|HGNC=7795|UniProtKB=Q00653	Nuclear factor NF-kappa-B p100 subunit	IGI	20151924	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00047	PDGF signaling pathway	P01172	c-Myc	CANLF|Ensembl=ENSCAFG00000030622|UniProtKB=J9P9G9	Uncharacterized protein	ISS	15094771	PubMed	PTHR13168:SF0	C-MYC-BINDING PROTEIN
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=628675|UniProtKB=Q9Z2A6	Mitogen-activated protein kinase 15	TAS	9891064	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00006	Apoptosis signaling pathway	P00260	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00648	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IGI	3755548	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000022548|UniProtKB=F6Y9J9	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ANOGA|EnsemblGenome=AGAP000651|UniProtKB=P84185	Actin-5C	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00029	Huntington disease	P00812	Caspase 3	CHICK|Ensembl=ENSGALG00000010638|UniProtKB=O93417	Caspase-3	IDA	11675509	PubMed	PTHR10454:SF198	CASPASE-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	CHICK|Ensembl=ENSGALG00000012357|UniProtKB=F1NAF4	Uncharacterized protein	ISS	4503175	gi	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00010	B cell activation	P00379	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00057	Wnt signaling pathway	P01444	Wnt	MACMU|Ensembl=ENSMMUG00000015709|UniProtKB=F6SLX4	Protein Wnt	ISS	14644163	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00057	Wnt signaling pathway	P01444	Wnt	CANLF|Ensembl=ENSCAFG00000032632|UniProtKB=J9P2Q5	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P06664	Gonadotropin-releasing hormone receptor pathway	P06841	gnaq/11	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	RCA	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00034	Integrin signalling pathway	P00916	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PANTR|Ensembl=ENSPTRG00000010369|UniProtKB=H2QF52	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF253	TUBULIN BETA-4A CHAIN
P00005	Angiogenesis	P00203	Erk	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00269	MAPK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	IC	15621031	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	MONDO|Ensembl=ENSMODG00000002071|UniProtKB=F6UZX8	10-formyltetrahydrofolate dehydrogenase	ISS			PTHR11699:SF131	MITOCHONDRIAL 10-FORMYLTETRAHYDROFOLATE DEHYDROGENASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	RAT|RGD=2732|UniProtKB=P22756	Glutamate receptor ionotropic, kainate 1	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00012	Cadherin signaling pathway	P00474	Wnt	XENTR|Xenbase=XB-GENE-484098|UniProtKB=F6ZQ88	Protein Wnt (Fragment)	ISS	11266476	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00056	VEGF signaling pathway	P01413	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02736	Coenzyme A biosynthesis	P02885	Pantothenate kinase	MACMU|Ensembl=ENSMMUG00000012521|UniProtKB=F7ECS7	Uncharacterized protein	ISS			PTHR12280:SF21	PANTOTHENATE KINASE 3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000014334|UniProtKB=F7CYY6	Uncharacterized protein	ISS	1319557	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00029	Huntington disease	P00790	beta-Tubulin	TAKRU|Ensembl=ENSTRUG00000012143|UniProtKB=H2U1C0	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P04393	Ras Pathway	P04567	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00052	TGF-beta signaling pathway	P01286	TGFbeta	PANTR|Ensembl=ENSPTRG00000010707|UniProtKB=H2QFT1	Growth differentiation factor 15	ISS	9326641	PubMed	PTHR11848:SF78	GROWTH/DIFFERENTIATION FACTOR 15
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	CANLF|Ensembl=ENSCAFG00000015856|UniProtKB=J9P3S5	Nucleoside diphosphate kinase	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P00049	Parkinson disease	P01219	SAPK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P02738	De novo purine biosynthesis	P02903	Phosphoribosylglycinamide  formyltransferase	ARATH|TAIR=AT5G47435|UniProtKB=Q93YQ3	Formyltetrahydrofolate deformylase 1, mitochondrial	ISS			PTHR42706:SF1	FORMYLTETRAHYDROFOLATE DEFORMYLASE 1, MITOCHONDRIAL-RELATED
P05731	GABA-B receptor II signaling	P05752	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	176910	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CAEEL|WormBase=WBGene00003776|UniProtKB=Q20641	Non-muscle MYosin	IC			PTHR13140:SF574	MYOSIN HEAVY CHAIN, NON-MUSCLE
P00056	VEGF signaling pathway	P01423	p38MAPK	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	ISS	10995439	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00052	TGF-beta signaling pathway	P01284	JNK	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	TAS	10514528	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00010	B cell activation	P00367	NFAT	HUMAN|HGNC=7778|UniProtKB=Q14934	Nuclear factor of activated T-cells, cytoplasmic 4	IDA	9133421	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00591	PLCbeta	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00050	Plasminogen activating cascade	P01249	pro-tPA	RAT|RGD=3342|UniProtKB=P19637	Tissue-type plasminogen activator	ISS	137121	gi	PTHR44617:SF1	TISSUE-TYPE PLASMINOGEN ACTIVATOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00010	B cell activation	P00379	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	NAS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00029	Huntington disease	P00775	Rac	MOUSE|MGI=MGI=1931551|UniProtKB=Q9ER71	Rho-related GTP-binding protein RhoJ	TAS	12932731	PubMed	PTHR24072:SF17	RHO-RELATED GTP-BINDING PROTEIN RHOJ
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00053	T cell activation	P01311	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00021	FGF signaling pathway	P00634	MEKK1-5	MACMU|Ensembl=ENSMMUG00000016376|UniProtKB=F7G2W1	Uncharacterized protein	ISS	12566458	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P05912	Dopamine receptor mediated signaling pathway	P05951	CDK5	MACMU|Ensembl=ENSMMUG00000020451|UniProtKB=F6VZU3	Uncharacterized protein	ISS	12372285	PubMed	PTHR24056:SF46	CYCLIN-DEPENDENT-LIKE KINASE 5
P00059	p53 pathway	P04609	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02736	Coenzyme A biosynthesis	P02885	Pantothenate kinase	CHICK|Ensembl=ENSGALG00000001895|UniProtKB=E1BWU5	Uncharacterized protein	ISS			PTHR12280:SF21	PANTOTHENATE KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00057	Wnt signaling pathway	P01446	Calcineurin	DANRE|ZFIN=ZDB-GENE-040912-18|UniProtKB=Q66HZ0	Uncharacterized protein	ISS	12015605	PubMed	PTHR23056:SF4	PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1
P00029	Huntington disease	G01533	Bax	XENTR|Xenbase=XB-GENE-486067|UniProtKB=Q6P4Y4	BCL2-associated X protein	ISS	8358790	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00049	Parkinson disease	P01222	Ubc6	XENTR|Xenbase=XB-GENE-956512|UniProtKB=A9JTQ9	Ube2j2 protein	ISS	12859888	PubMed	PTHR43972:SF1	UBIQUITIN-CONJUGATING ENZYME E2 J2
P00021	FGF signaling pathway	P00641	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00048	PI3 kinase pathway	P01199	Galpha	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00021	FGF signaling pathway	P00627	ERK1-2	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IGI	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04569	Cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00030	Hypoxia response via HIF activation	P00819	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01275	P38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	TAS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IC	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04380	Cortocotropin releasing factor receptor signaling pathway	P04454	CRF	MACMU|Ensembl=ENSMMUG00000021587|UniProtKB=F7E8Q2	Uncharacterized protein	ISS	122560	OMIM	PTHR15035:SF9	CORTICOLIBERIN
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MOUSE|MGI=MGI=95823|UniProtKB=Q03391	Glutamate receptor ionotropic, NMDA 2D	ISS	11554549	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04392	P53 pathway feedback loops 1	P04539	p53	MOUSE|MGI=MGI=1330810|UniProtKB=O88898	Tumor protein 63	TAS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P05730	Endogenous cannabinoid signaling	P05746	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06861	MAP4Ks	MOUSE|MGI=MGI=1925503|UniProtKB=Q8BPM2	Mitogen-activated protein kinase kinase kinase kinase 5	RCA	11316611	PubMed	PTHR24361:SF324	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 5
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=88354|UniProtKB=P09803	Cadherin-1	IDA	12834808	PubMed	PTHR24027:SF319	CADHERIN-1
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	ECOLI|EcoGene=EG10421|UniProtKB=P0ADG7	Inosine-5'-monophosphate dehydrogenase	ISS			PTHR11911:SF6	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IDA	12707323	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00019	Endothelin signaling pathway	P00572	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00053	T cell activation	P01305	Calmodulin	PHYPA|Gene=PHYPADRAFT_185037|UniProtKB=A9SHH7	Predicted protein	ISS			PTHR23050:SF245	AT16150P-RELATED
P00024	Glycolysis	P00677	Hexokinase	HUMAN|HGNC=23302|UniProtKB=Q2TB90	Putative hexokinase HKDC1	RCA			PTHR19443:SF28	HEXOKINASE HKDC1-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02743	Formyltetrahydroformate biosynthesis	P02954	Thymidylate synthase	ANOGA|EnsemblGenome=AGAP010457|UniProtKB=Q7QDW7	AGAP010457-PA	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	TAKRU|Ensembl=ENSTRUG00000013411|UniProtKB=H2UB84	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	IDA	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00015	Circadian clock system	P00505	Cry	PANTR|Ensembl=ENSPTRG00000005396|UniProtKB=H2Q6S7	Cryptochrome 1 (Photolyase-like)	ISS	10217146	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DANRE|ZFIN=ZDB-GENE-040625-35|UniProtKB=Q6IQL9	Novel actin protein	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P02749	Leucine biosynthesis	P03001	3-Isopropylmalate dehydrogenase	ARATH|TAIR=AT1G31180|UniProtKB=Q9SA14	3-isopropylmalate dehydrogenase 1, chloroplastic	ISS			PTHR42979:SF3	3-ISOPROPYLMALATE DEHYDROGENASE 1, CHLOROPLASTIC-RELATED
P00034	Integrin signalling pathway	P00941	Integrin alpha	MOUSE|MGI=MGI=96602|UniProtKB=Q62470	Integrin alpha-3	IPI	3487386	PubMed	PTHR23220:SF89	INTEGRIN ALPHA-3
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	MACMU|Ensembl=ENSMMUG00000017431|UniProtKB=F7HPP3	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00010	B cell activation	P00391	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00048	PI3 kinase pathway	P01199	Galpha	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	XENTR|Xenbase=XB-GENE-5932067|UniProtKB=F6RLM5	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF74	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA
P04393	Ras Pathway	P04546	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	RAT|RGD=2034|UniProtKB=P26770	Adenylate cyclase type 4	IGI	2491850	PubMed	PTHR11920:SF286	ADENYLATE CYCLASE TYPE 4
P00019	Endothelin signaling pathway	P00582	COX-2	CHICK|Gene=PTGS2|UniProtKB=P27607	Prostaglandin G/H synthase 2	IGI	1849272	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P00049	Parkinson disease	P01235	Fyn kinase	DANRE|ZFIN=ZDB-GENE-050706-89|UniProtKB=F1RDG9	Tyrosine-protein kinase fynb	ISS	11162638	PubMed	PTHR24418:SF242	TYROSINE-PROTEIN KINASE FYNB
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=97614|UniProtKB=Q8R3B1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	15611108	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00001	Adrenaline and noradrenaline biosynthesis	P00070	VAT2	HUMAN|HGNC=10935|UniProtKB=Q05940	Synaptic vesicular amine transporter	IC	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00052	TGF-beta signaling pathway	P01286	TGFbeta	CHICK|Ensembl=ENSGALG00000009256|UniProtKB=F1P5H1	Uncharacterized protein	TAS	9759503	PubMed	PTHR11848:SF7	SIGNALING MOLECULE LEFTY1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04674	Mdm2	RAT|RGD=1305332|UniProtKB=A0A0G2JVC1	Protein Mdm2	ISS	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00056	VEGF signaling pathway	P01409	cPLA2	CHICK|Ensembl=ENSGALG00000005065|UniProtKB=P49147	Cytosolic phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	RCA			PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	ISS	http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00019	Endothelin signaling pathway	P00585	ECE1-3	MACMU|Ensembl=ENSMMUG00000018955|UniProtKB=F6U0N1	Uncharacterized protein	ISS	95318093	PubMed	PTHR11733:SF127	ENDOTHELIN-CONVERTING ENZYME 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00036	Interleukin signaling pathway	P00968	Ikk	PANTR|Ensembl=ENSPTRG00000033948|UniProtKB=H2RBD4	Conserved helix-loop-helix ubiquitous kinase	ISS	14499113	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00010	B cell activation	P00383	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	ARATH|TAIR=AT1G55880|UniProtKB=Q6NKY5	At1g55880	ISS			PTHR10314:SF35	CYSTEINE SYNTHASE-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	MOUSE|MGI=MGI=106217|UniProtKB=Q61290	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	8386525	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00021	FGF signaling pathway	P00627	ERK1-2	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	NEUCR|EnsemblGenome=EFNCRG00000003957|UniProtKB=V5ILY7	Protein kinase gsk3	TAS			PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00005	Angiogenesis	P00189	Fzd	HUMAN|HGNC=4038|UniProtKB=Q9UP38	Frizzled-1	IDA	12549854	PubMed	PTHR11309:SF81	FRIZZLED-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MOUSE|MGI=MGI=99675|UniProtKB=Q8VHH7	Adenylate cyclase type 3	IDA	2491850	PubMed	PTHR11920:SF291	ADENYLATE CYCLASE TYPE 3
P00058	mRNA splicing	P01476	U4	CANLF|Ensembl=ENSCAFG00000011820|UniProtKB=E2R4I0	Uncharacterized protein	ISS	9328476	PubMed	PTHR14212:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3
P02738	De novo purine biosynthesis	P02889	dGDP kinase	BOVIN|Ensembl=ENSBTAG00000016552|UniProtKB=A5PK70	Nucleoside diphosphate kinase	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	BOVIN|Ensembl=ENSBTAG00000016198|UniProtKB=E1B8D6	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	CAEEL|WormBase=WBGene00000552|UniProtKB=O16305	Calmodulin	ISS	3885394	PubMed	PTHR23050:SF236	CALMODULIN
P00029	Huntington disease	P00788	Calpain	CAEEL|WormBase=WBGene00006606|UniProtKB=Q22036	Calpain-5	IDA	11675509	PubMed	PTHR10183:SF281	CALPAIN-5
P00017	DNA replication	P00527	Histones	BOVIN|Ensembl=ENSBTAG00000045914|UniProtKB=G3MYD7	Histone H3	ISS	12413958	PubMed	PTHR11426:SF179	HISTONE H3.3
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00010	B cell activation	P00369	MEKK	PANTR|Ensembl=ENSPTRG00000009518|UniProtKB=H2QDN0	Mitogen-activated protein kinase kinase kinase 3	ISS	8649450	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00020	FAS signaling pathway	P00601	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PLAF7|EnsemblGenome=PF14_0124|UniProtKB=Q8ILW9	Actin-2	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04392	P53 pathway feedback loops 1	P04540	Cop-1	XENTR|Xenbase=XB-GENE-1014311|UniProtKB=F7CIC4	Uncharacterized protein (Fragment)	ISS	15103385	PubMed	PTHR44080:SF1	E3 UBIQUITIN-PROTEIN LIGASE RFWD2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00052	TGF-beta signaling pathway	P01284	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	RAT|RGD=1311101|UniProtKB=D4AC20	Cytidine deaminase (Predicted)	ISS			PTHR11644:SF2	CYTIDINE DEAMINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2743|UniProtKB=P31421	Metabotropic glutamate receptor 2	IDA	9407094	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_56687|UniProtKB=C3YC50	Putative uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01162	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P06587	Nicotine pharmacodynamics pathway	P06596	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8617307	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00010	B cell activation	P00397	IKK	BOVIN|Ensembl=ENSBTAG00000007599|UniProtKB=Q95KV0	Inhibitor of nuclear factor kappa-B kinase subunit beta	IGI	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00036	Interleukin signaling pathway	P00980	IRS1/2	MOUSE|MGI=MGI=99454|UniProtKB=P35569	Insulin receptor substrate 1	IDA	5031805	gi	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	HUMAN|HGNC=1953|UniProtKB=P08173	Muscarinic acetylcholine receptor M4	ISS	10069496	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ORYSJ|EnsemblGenome=OS11G0163100|UniProtKB=Q67G20	Actin	IDA			PTHR11937:SF155	ACTIN-5C-RELATED
P00048	PI3 kinase pathway	P01192	p110	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	TAS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00643	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=62087|UniProtKB=P27704	Mitogen-activated protein kinase 6	ISS	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	PANTR|Ensembl=ENSPTRG00000017581|UniProtKB=H2QS37	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF179	REGULATOR OF G-PROTEIN SIGNALING 14
P00029	Huntington disease	P00780	Microtubule	NEUCR|EnsemblGenome=EFNCRG00000003612|UniProtKB=P05220	Tubulin beta chain	IDA	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	MOUSE|MGI=MGI=103038|UniProtKB=P42227	Signal transducer and activator of transcription 3	TAS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	IDA	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00021	FGF signaling pathway	P00644	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CAEBR|Gene=CBG18715|UniProtKB=A8XTZ1	Phosphoinositide phospholipase C	ISS			PTHR10336:SF91	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00011	Blood coagulation	P00409	PAI-2	MOUSE|MGI=MGI=97609|UniProtKB=P12388	Plasminogen activator inhibitor 2, macrophage	ISS	6755098	gi	PTHR11461:SF61	PLASMINOGEN ACTIVATOR INHIBITOR 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00036	Interleukin signaling pathway	P00973	PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00107	kinesin	PANTR|Ensembl=ENSPTRG00000018187|UniProtKB=H2QT19	Uncharacterized protein	ISS	11740561	PubMed	PTHR19959:SF139	KINESIN LIGHT CHAIN 4
P00021	FGF signaling pathway	P00629	PP2A	MACMU|Ensembl=ENSMMUG00000021986|UniProtKB=F6RRV0	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform	ISS	11994459	PubMed	PTHR10648:SF2	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 65 KDA REGULATORY SUBUNIT A ALPHA ISOFORM
P02751	Lysine biosynthesis	P03008	Dihydrodipicolinate synthase	SULSO|EnsemblGenome=SSO2274|UniProtKB=Q97WF2	Dihydrodipicolinate synthase (DapA-1)	ISS			PTHR12128:SF15	4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL
P00010	B cell activation	P00383	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00034	Integrin signalling pathway	P00941	Integrin alpha	PANTR|Ensembl=ENSPTRG00000014748|UniProtKB=H2QMA4	Uncharacterized protein	ISS	10209034	PubMed	PTHR23220:SF69	INTEGRIN ALPHA-9
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	RAT|RGD=2959|UniProtKB=P48550	G protein-activated inward rectifier potassium channel 2	IDA	2433589	PubMed	PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P00052	TGF-beta signaling pathway	P01284	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TAKRU|Ensembl=ENSTRUG00000005447|UniProtKB=P68142	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF354	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00183	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	DANRE|ZFIN=ZDB-GENE-040426-2575|UniProtKB=E7FC99	Uncharacterized protein	ISS			PTHR23315:SF68	SUBFAMILY NOT NAMED
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01199	Galpha	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	7565716	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P06959	CCKR signaling map	P07034	CaMKK	HUMAN|HGNC=1469|UniProtKB=Q8N5S9	Calcium/calmodulin-dependent protein kinase kinase 1	RCA	10838169	PubMed	PTHR44035:SF1	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE 1
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	IDA	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P05731	GABA-B receptor II signaling	P05760	AC	HUMAN|HGNC=237|UniProtKB=O43306	Adenylate cyclase type 6	RCA	2491850	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04393	Ras Pathway	P04558	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00056	VEGF signaling pathway	P01408	Akt/PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	CANLF|Ensembl=ENSCAFG00000010787|UniProtKB=E2R3W6	Uncharacterized protein	ISS	1319557	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00056	VEGF signaling pathway	P01418	Paxillin	DROME|FlyBase=FBgn0041789|UniProtKB=Q2PDT4	Paxillin, isoform F	ISS			PTHR24216:SF8	PAXILLIN, ISOFORM F
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	MONDO|Ensembl=ENSMODG00000003295|UniProtKB=F7EG01	Serine/threonine-protein kinase receptor	ISS	11252892	PubMed	PTHR23255:SF64	ACTIVIN RECEPTOR TYPE-2A
P00029	Huntington disease	P00775	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01185	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00006	Apoptosis signaling pathway	P00321	HSP70	PANTR|Ensembl=ENSPTRG00000000563|UniProtKB=H2PYQ3	Heat shock 70kDa protein 5 (Glucose-regulated protein, 78kDa)	ISS	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00036	Interleukin signaling pathway	P00964	p90RSK	CANLF|Ensembl=ENSCAFG00000000828|UniProtKB=F6UWI0	Ribosomal protein S6 kinase	ISS	1922062	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00010	B cell activation	P00371	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P02756	N-acetylglucosamine metabolism	P03036	N-acetylglucosamine-6-phosphate deacetylase	MYCTU|EnsemblGenome=LH57_18215|UniProtKB=O53382	N-acetylglucosamine-6-phosphate deacetylase	ISS			PTHR11113:SF1	N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DANRE|ZFIN=ZDB-GENE-040426-1354|UniProtKB=Q7T2C5	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	RAT|RGD=1593806|UniProtKB=G3V8Y0	Protein Gng13	ISS	10391901	PubMed	PTHR15936:SF2	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-13
P00054	Toll receptor signaling pathway	P01369	MKK1	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00049	Parkinson disease	P01211	ERK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	IDA	6466184	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00049	Parkinson disease	P01236	Casein kinase II	BOVIN|Gene=CSNK2A2|UniProtKB=P20427	Casein kinase II subunit alpha'	IDA	10617630	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P05731	GABA-B receptor II signaling	P05752	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00932	FAK	MONDO|Ensembl=ENSMODG00000000707|UniProtKB=F6WLE6	Uncharacterized protein	ISS	12640026	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P02783	Tryptophan biosynthesis	P03209	Anthranilate phosphoribosyl transferase	GLOVI|EnsemblGenome=BAC90736|UniProtKB=Q7NGU2	Anthranilate phosphoribosyltransferase	ISS			PTHR43285:SF2	ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00011	Blood coagulation	P00406	Fibrinogen	BOVIN|Gene=FGG|UniProtKB=P12799	Fibrinogen gamma-B chain	ISS	120140	gi	PTHR19143:SF338	FIBRINOGEN GAMMA CHAIN
P00053	T cell activation	P01300	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000037985|UniProtKB=F1MCK3	Muscarinic acetylcholine receptor	ISS			PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	NEUCR|EnsemblGenome=EFNCRG00000003164|UniProtKB=V5ILP2	MAP kinase kinase kinase	ISS			PTHR24361:SF611	SERINE/THREONINE-PROTEIN KINASE BCK1/SLK1/SSP31
P00021	FGF signaling pathway	P00648	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CHICK|Ensembl=ENSGALG00000001462|UniProtKB=F1NSB8	Adenosine receptor A3	IDA	12515326	PubMed	PTHR24246:SF2	ADENOSINE RECEPTOR A3
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-030131-9966|UniProtKB=Q6TH03	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	HUMAN|HGNC=1392|UniProtKB=Q15878	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	14507926	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	CHICK|Ensembl=ENSGALG00000002098|UniProtKB=F1P0L4	Uncharacterized protein	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	CANLF|Ensembl=ENSCAFG00000015815|UniProtKB=F1Q4F5	Adenylosuccinate synthetase isozyme 2	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04393	Ras Pathway	P04570	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05734	Synaptic vesicle trafficking	P05770	Munc18	MONDO|Ensembl=ENSMODG00000004636|UniProtKB=F6XL12	Uncharacterized protein	ISS	8108429	PubMed	PTHR11679:SF35	SYNTAXIN-BINDING PROTEIN 1
P00005	Angiogenesis	P00227	PLA2	DANRE|ZFIN=ZDB-GENE-990415-45|UniProtKB=P50392	Cytosolic phospholipase A2	ISS	94299545	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	ORYSJ|EnsemblGenome=OS07G0694000|UniProtKB=Q6Z3Y9	Phosphoinositide phospholipase C	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	3045562	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00004	Alzheimer disease-presenilin pathway	P00118	E-cadherin	HUMAN|HGNC=1762|UniProtKB=P22223	Cadherin-3	IDA	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	HUMAN|HGNC=19663|UniProtKB=Q9UBI6	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IDA	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	RAT|RGD=628852|UniProtKB=Q02294	Voltage-dependent N-type calcium channel subunit alpha-1B	IDA	8386525	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	IDA	97320448	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	BOVIN|Gene=CACNB1|UniProtKB=Q9MZL7	Voltage-dependent L-type calcium channel subunit beta-1	IC	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P04392	P53 pathway feedback loops 1	P04539	p53	RAT|RGD=1307083|UniProtKB=D4AA88	Protein Tp73	ISS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P06664	Gonadotropin-releasing hormone receptor pathway	P06807	gnai	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00036	Interleukin signaling pathway	P00965	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IC	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	TAS	7565716	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	HUMAN|HGNC=7776|UniProtKB=Q13469	Nuclear factor of activated T-cells, cytoplasmic 2	ISS	9133421	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	8925912	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00034	Integrin signalling pathway	P00920	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CHLRE|EnsemblGenome=CHLREDRAFT_193901|UniProtKB=Q9FXT7	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	PANTR|Ensembl=ENSPTRG00000015241|UniProtKB=Q5IS72	D(3) dopamine receptor	ISS	2039532	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00047	PDGF signaling pathway	P01168	PI3K	XENTR|Xenbase=XB-GENE-6067221|UniProtKB=F6Z0J4	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P05731	GABA-B receptor II signaling	P05760	AC	CANLF|Gene=ADCY6|UniProtKB=P30804	Adenylate cyclase type 6	RCA	92409599	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	BRAFL|Gene=BRAFLDRAFT_120208|UniProtKB=C3YMF1	Putative uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF89	TUBULIN BETA-4 CHAIN
P05731	GABA-B receptor II signaling	P05754	Ggamma	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	RCA	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	DANRE|ZFIN=ZDB-GENE-030729-1|UniProtKB=B3DGN0	Opioid receptor, kappa 1	IDA	11259498	PubMed	PTHR24229:SF1	KAPPA-TYPE OPIOID RECEPTOR
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00221	JNK1	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00036	Interleukin signaling pathway	P00996	STAT	BOVIN|Gene=STAT5B|UniProtKB=Q9TUM3	Signal transducer and activator of transcription 5B	IC	96102059	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000016815|UniProtKB=F7C9S6	Uncharacterized protein	ISS	12181435	PubMed	PTHR24229:SF52	SOMATOSTATIN RECEPTOR TYPE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	TAS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	SCHPO|PomBase=SPAC8C9.03|UniProtKB=P36600	cAMP-dependent protein kinase regulatory subunit	IC	176892	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P06959	CCKR signaling map	G06986	CCND1	HUMAN|HGNC=1582|UniProtKB=P24385	G1/S-specific cyclin-D1	RCA	17167838	PubMed	PTHR10177:SF67	G1/S-SPECIFIC CYCLIN-D1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=97614|UniProtKB=Q8R3B1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	7822322	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01444	Wnt	MACMU|Ensembl=ENSMMUG00000018445|UniProtKB=F7HEW6	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00054	Toll receptor signaling pathway	P01369	MKK1	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02763	Peptidoglycan biosynthesis	P03084	UDP-N-acetylmuramoylalanyl-D-glutamate 2,6-diaminopimelate ligase	STRCO|EnsemblGenome=CAB51998|UniProtKB=Q9S2W7	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase	ISS			PTHR23135:SF4	UDP-N-ACETYLMUAMOYLALANYL-D-GLUTAMATE-2,6-DIAMINOPIMELATE LIGASE-RELATED
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00004	Alzheimer disease-presenilin pathway	P00141	Membrane metalloprotease	MACMU|Ensembl=ENSMMUG00000013665|UniProtKB=F7GFT1	Matrix metalloproteinase-14 preproprotein	ISS	12834808	PubMed	PTHR10201:SF24	MATRIX METALLOPROTEINASE-14
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00053	T cell activation	P01336	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00584	Gs	CHICK|Ensembl=ENSGALG00000007509|UniProtKB=F1NM72	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CAEEL|WormBase=WBGene00003774|UniProtKB=G5EGQ9	NMDA class glutamate Receptor	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00021	FGF signaling pathway	P00644	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IGI	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00054	Toll receptor signaling pathway	P01368	MKK2	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	CANLF|Ensembl=ENSCAFG00000013324|UniProtKB=F1PCS0	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-8225|UniProtKB=Q7SZZ5	Uncharacterized protein	ISS			PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00047	PDGF signaling pathway	P01155	Jak	CANLF|Ensembl=ENSCAFG00000018615|UniProtKB=F1PIY7	Tyrosine-protein kinase	ISS	11929133	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00029	Huntington disease	P00796	Kainate receptor	MOUSE|MGI=MGI=95816|UniProtKB=B1AS29	Glutamate receptor ionotropic, kainate 3	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00053	T cell activation	P01306	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	XENTR|Xenbase=XB-GENE-854877|UniProtKB=F7C949	Presenilin	ISS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	TAKRU|Ensembl=ENSTRUG00000015631|UniProtKB=H2USP0	Uncharacterized protein	ISS			PTHR11681:SF14	SUBFAMILY NOT NAMED
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IDA	3755548	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	TAS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00778	NMDA receptor	CANLF|Ensembl=ENSCAFG00000002617|UniProtKB=E2QUL1	Uncharacterized protein	ISS	14698601	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00005	Angiogenesis	P00256	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Ensembl=ENSBTAG00000013047|UniProtKB=E1BLE8	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00034	Integrin signalling pathway	P00927	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	XENTR|Xenbase=XB-GENE-483731|UniProtKB=Q5BL72	Frizzled-7	ISS	11212302	PubMed	PTHR11309:SF31	FRIZZLED-7
P00048	PI3 kinase pathway	P01188	Gbetagamma	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_56698|UniProtKB=C3XYC3	Putative uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	BOVIN|Ensembl=ENSBTAG00000007882|UniProtKB=G3X7Z2	Uncharacterized protein	IDA	14507926	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00045	Notch signaling pathway	P01114	Ntm	RAT|RGD=620761|UniProtKB=Q9R172	Neurogenic locus notch homolog protein 3	ISS	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IDA	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00018	EGF receptor signaling pathway	P00551	Akt	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	IGI	95181376	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00006	Apoptosis signaling pathway	P00274	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DROME|FlyBase=FBgn0000044|UniProtKB=P53501	Actin-57B	IC	14684598	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00059	p53 pathway	P04609	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	DROME|FlyBase=FBgn0001123|UniProtKB=P20354	G protein alpha s subunit	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00019	Endothelin signaling pathway	P00577	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01199	Galpha	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01411	Ras	CHICK|Ensembl=ENSGALG00000006885|UniProtKB=P08642	GTPase HRas	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00021	FGF signaling pathway	P00632	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00034	Integrin signalling pathway	P00913	Csk	XENTR|Xenbase=XB-GENE-5771921|UniProtKB=F6UTP2	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00018	EGF receptor signaling pathway	P00560	Raf-1	TAKRU|Ensembl=ENSTRUG00000006611|UniProtKB=H2SV11	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02784	Tyrosine biosynthesis	P03213	Aromatic amino acid aminotransferase	MOUSE|MGI=MGI=98487|UniProtKB=Q8QZR1	Tyrosine aminotransferase	ISS			PTHR11751:SF368	TYROSINE AMINOTRANSFERASE
P00029	Huntington disease	G01532	PolyQ HTT	CANLF|Ensembl=ENSCAFG00000014682|UniProtKB=F1P7Y7	Uncharacterized protein	ISS	8268927	PubMed	PTHR10170:SF10	HUNTINGTIN
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00060	Ubiquitin proteasome pathway	P01490	E3	RAT|RGD=3157|UniProtKB=Q62940	E3 ubiquitin-protein ligase NEDD4	ISS			PTHR11254:SF282	E3 UBIQUITIN-PROTEIN LIGASE NEDD4
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	9298898	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01320	PLC-gamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	CAEEL|WormBase=WBGene00000048|UniProtKB=Q18556	AcetylCholine Receptor	IC	11404397	PubMed	PTHR18945:SF528	ACETYLCHOLINE RECEPTOR
P00029	Huntington disease	P00778	NMDA receptor	PANTR|Ensembl=ENSPTRG00000004718|UniProtKB=H2Q5I0	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P02781	Threonine biosynthesis	P03190	Threonine synthase	BRADU|Gene=BAC46446|UniProtKB=Q89V75	Threonine synthase	ISS			PTHR42690:SF1	THREONINE SYNTHASE-LIKE 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00752	cGMP-gated ion channel	HUMAN|HGNC=2151|UniProtKB=Q14028	Cyclic nucleotide-gated cation channel beta-1	IDA	12432397	PubMed	PTHR10217:SF386	CYCLIC NUCLEOTIDE-GATED CATION CHANNEL BETA-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	PANTR|Ensembl=ENSPTRG00000004718|UniProtKB=H2Q5I0	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	IDA	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	TAS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IDA	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00029	Huntington disease	P00763	Hip-12	HUMAN|HGNC=18415|UniProtKB=O75146	Huntingtin-interacting protein 1-related protein	RCA			PTHR10407:SF10	HUNTINGTIN-INTERACTING PROTEIN 1-RELATED PROTEIN
P00005	Angiogenesis	P00226	Delta/Serrate	BOVIN|Ensembl=ENSBTAG00000012817|UniProtKB=E1BDN7	Delta-like protein	ISS	1286675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01162	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	RAT|RGD=620023|UniProtKB=P10980	Muscarinic acetylcholine receptor M2	TAS	91373358	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00059	p53 pathway	P04610	Cyclin E	HUMAN|HGNC=1589|UniProtKB=P24864	G1/S-specific cyclin-E1	IPI	12628165	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT2G43790|UniProtKB=Q39026	Mitogen-activated protein kinase 6	ISS	10851062	PubMed	PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P00023	General transcription regulation	P00658	TBP-associated factors	HUMAN|HGNC=11537|UniProtKB=O00268	Transcription initiation factor TFIID subunit 4	ISS	10973244	PubMed	PTHR15138:SF18	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4
P00052	TGF-beta signaling pathway	P01288	FKBP12	MOUSE|MGI=MGI=95542|UniProtKB=P45878	Peptidyl-prolyl cis-trans isomerase FKBP2	ISS			PTHR10516:SF333	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP2
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00729	Goalpha	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	IDA	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	12805548	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00010	B cell activation	P00383	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00019	Endothelin signaling pathway	P00572	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT1G07880|UniProtKB=Q9LQQ9	Mitogen-activated protein kinase 13	IDA	10514528	PubMed	PTHR24055:SF185	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00005	Angiogenesis	P00193	SOS-1	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00056	VEGF signaling pathway	P01409	cPLA2	MONDO|Ensembl=ENSMODG00000011791|UniProtKB=F7CBU9	Phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	RAT|RGD=1588452|UniProtKB=P85108	Tubulin beta-2A chain	ISS	9454836	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01435	SWI/SNF	YEAST|SGD=S000005816|UniProtKB=P22082	Transcription regulatory protein SNF2	IDA	11532957	PubMed	PTHR10799:SF854	ATP-DEPENDENT HELICASE BRM
P00057	Wnt signaling pathway	P01465	Ggamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02771	Pyrimidine Metabolism	P03129	Aminotransferase	PANTR|Ensembl=ENSPTRG00000007746|UniProtKB=H2QAJ4	4-aminobutyrate aminotransferase	ISS	10989446	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00037	Ionotropic glutamate receptor pathway	P01018	Glu1	CHICK|Ensembl=ENSGALG00000004083|UniProtKB=Q90855	AMPA receptor GluR1/A	ISS	10331083	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IGI	2372396	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00024	Glycolysis	P00678	Enolase	CHICK|Gene=ENO1|UniProtKB=P51913	Alpha-enolase	ISS	99439677	PubMed	PTHR11902:SF12	ALPHA-ENOLASE
P00019	Endothelin signaling pathway	P00589	Akt	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	ISS	12719720	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00049	Parkinson disease	P01209	19S proteasome	YEAST|SGD=S000002835|UniProtKB=Q04062	26S proteasome regulatory subunit RPN9	TAS	12859888	PubMed	PTHR10539:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00036	Interleukin signaling pathway	P00995	c-Myc	BOVIN|Ensembl=ENSBTAG00000008409|UniProtKB=Q2HJ27	Myc proto-oncogene protein	ISS	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00019	Endothelin signaling pathway	P00571	Pro ET1-4	MOUSE|MGI=MGI=95284|UniProtKB=P22389	Endothelin-2	ISS			PTHR13874:SF9	ENDOTHELIN-2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	PANTR|Ensembl=ENSPTRG00000020481|UniProtKB=H2QWI9	Ribonucleotide reductase M2 B (TP53 inducible)	ISS			PTHR23409:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 B
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00053	T cell activation	P01307	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	CHICK|Ensembl=ENSGALG00000002550|UniProtKB=O57340	Thyrotropin subunit beta	ISS	3017658	PubMed	PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P00022	General transcription by RNA polymerase I	P00652	RNA Polymerase I  Complex	NEUCR|EnsemblGenome=EFNCRG00000008647|UniProtKB=O74633	DNA-directed RNA polymerase I subunit RPA2	ISS	15691654	PubMed	PTHR20856:SF5	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P02775	Salvage pyrimidine ribonucleotides	P03149	Cytidine kinase	BOVIN|Ensembl=ENSBTAG00000015798|UniProtKB=E1BP85	Uridine kinase	ISS			PTHR10285:SF68	URIDINE-CYTIDINE KINASE-LIKE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	CHICK|Ensembl=ENSGALG00000009705|UniProtKB=F1NSR9	Uncharacterized protein	ISS	15226293	PubMed	PTHR13715:SF16	RYANODINE RECEPTOR 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P05918	p38 MAPK pathway	P06021	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	MACMU|Ensembl=ENSMMUG00000005008|UniProtKB=F6VJI3	Cyclic AMP-responsive element-binding protein 3-like protein 4	ISS	1354612	PubMed	PTHR22952:SF105	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 4
P04398	p53 pathway feedback loops 2	G04712	P21	PANTR|Ensembl=ENSPTRG00000018107|UniProtKB=H2RFJ9	Uncharacterized protein	ISS	7774811	PubMed	PTHR10265:SF16	CYCLIN-DEPENDENT KINASE INHIBITOR 1
P00006	Apoptosis signaling pathway	P00269	MAPK	YEAST|SGD=S000003272|UniProtKB=P14681	Mitogen-activated protein kinase KSS1	ISS	10514528	PubMed	PTHR24055:SF338	MITOGEN-ACTIVATED PROTEIN KINASE KSS1
P04398	p53 pathway feedback loops 2	G04714	PTEN	XENTR|Xenbase=XB-GENE-491433|UniProtKB=B1H2U0	Pten protein	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04395	Vasopressin synthesis	P04596	Endo Peptidase	HUMAN|HGNC=30228|UniProtKB=Q4J6C6	Prolyl endopeptidase-like	IC	9695945	PubMed	PTHR11757:SF12	PROLYL ENDOPEPTIDASE-LIKE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	TAS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00046	Oxidative stress response	P01134	cPLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	TAS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	XENTR|Xenbase=XB-GENE-956713|UniProtKB=Q5XGD8	Guanine nucleotide binding protein, beta 3	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00048	PI3 kinase pathway	P01182	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00010	B cell activation	P00385	Rac	MACMU|Ensembl=ENSMMUG00000021075|UniProtKB=F7GY91	Uncharacterized protein	ISS	11756405	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P02723	Adenine and hypoxanthine salvage pathway	P02810	Adenine phosphoribosyl transferase	RAT|RGD=1307758|UniProtKB=P36972	Adenine phosphoribosyltransferase	ISS			PTHR32315:SF3	ADENINE PHOSPHORIBOSYLTRANSFERASE
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	PANTR|Ensembl=ENSPTRG00000003946|UniProtKB=H2Q482	Protein-serine/threonine kinase	ISS	10852916	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00018	EGF receptor signaling pathway	P00551	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IGI	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	TAKRU|Ensembl=ENSTRUG00000009259|UniProtKB=H2TF39	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	TAS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	RAT|RGD=3868|UniProtKB=Q07141	Transducin-like enhancer protein 4	IDA	9783586	PubMed	PTHR10814:SF21	TRANSDUCIN-LIKE ENHANCER PROTEIN 4
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	IDA	97320448	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02727	Androgen/estrogene/progesterone biosynthesis	P02829	Cholesterol acyltransferase	PANTR|Ensembl=ENSPTRG00000005002|UniProtKB=H2Q613	O-acyltransferase	ISS	9756918	PubMed	PTHR10408:SF10	STEROL O-ACYLTRANSFERASE 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12880387	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Ensembl=ENSBTAG00000037726|UniProtKB=P10895	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	15611108	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00048	PI3 kinase pathway	P01188	Gbetagamma	SCHPO|PomBase=SPBC32H8.07|UniProtKB=Q10282	Guanine nucleotide-binding protein subunit beta	IC	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05994	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00010	B cell activation	P00379	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00046	Oxidative stress response	P01138	MKK4	RAT|RGD=1311192|UniProtKB=A0A0G2K3R1	Protein Map3k4	ISS	11730323	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00036	Interleukin signaling pathway	P00985	PDK1/2	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	IDA	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00057	Wnt signaling pathway	P01428	Frizzled	MACMU|Ensembl=ENSMMUG00000022114|UniProtKB=F7H7V5	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF81	FRIZZLED-1
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MOUSE|MGI=MGI=1346875|UniProtKB=O08648	Mitogen-activated protein kinase kinase kinase 4	IGI	602425	OMIM	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00034	Integrin signalling pathway	P00947	Laminin	MOUSE|MGI=MGI=1918264|UniProtKB=Q8BH27	Multiple epidermal growth factor-like domains protein 9	IPI	2538453	PubMed	PTHR10574:SF298	MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN 9
P00018	EGF receptor signaling pathway	P00551	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	CHICK|Ensembl=ENSGALG00000016406|UniProtKB=F1NLJ3	Uncharacterized protein	ISS	6755374	gi	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000000985|UniProtKB=F6VRS9	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00057	Wnt signaling pathway	P01471	alpha-catenin	PANTR|Ensembl=ENSPTRG00000017291|UniProtKB=H2QRK9	Catenin (Cadherin-associated protein), alpha 1, 102kDa	ISS	10456847	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00036	Interleukin signaling pathway	P00965	ERK	MACMU|Ensembl=ENSMMUG00000008536|UniProtKB=F6WBZ5	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00029	Huntington disease	P00780	Microtubule	DANRE|ZFIN=ZDB-GENE-050522-384|UniProtKB=F1QKY8	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00010	B cell activation	P00391	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DROME|FlyBase=FBgn0015765|UniProtKB=O62618	Mitogen-activated protein kinase 14A	IDA	10851062	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	HUMAN|HGNC=14131|UniProtKB=Q9P2W3	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13	IC	10391901	PubMed	PTHR15936:SF2	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-13
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	HUMAN|HGNC=143|UniProtKB=P68032	Actin, alpha cardiac muscle 1	IC	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MOUSE|MGI=MGI=87905|UniProtKB=P68033	Actin, alpha cardiac muscle 1	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00034	Integrin signalling pathway	P00922	Collagen	MOUSE|MGI=MGI=88455|UniProtKB=P08122	Collagen alpha-2(IV) chain	IDA	10778855	PubMed	PTHR24023:SF588	COLLAGEN ALPHA-2 IV  CHAIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00778	NMDA receptor	XENTR|Xenbase=XB-GENE-494200|UniProtKB=F7CS79	Uncharacterized protein	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P02769	Purine metabolism	P03117	5'-AMP Deaminase	CANLF|Ensembl=ENSCAFG00000007562|UniProtKB=E2R740	Uncharacterized protein	ISS	1420359	PubMed	PTHR11359:SF2	AMP DEAMINASE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	HUMAN|HGNC=1389|UniProtKB=Q00975	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	11976940	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00011	Blood coagulation	P00421	alpha1-antitrypsin	MACMU|Ensembl=ENSMMUG00000020426|UniProtKB=F6SEN6	Alpha-1-antitrypsin	ISS	2116650	gi	PTHR11461:SF165	ALPHA-1-ANTITRYPSIN-RELATED
P00006	Apoptosis signaling pathway	P00313	IKK	CANLF|Ensembl=ENSCAFG00000005526|UniProtKB=E2RKR0	Uncharacterized protein	ISS	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	BOVIN|Ensembl=ENSBTAG00000046248|UniProtKB=Q58CQ2	Actin-related protein 2/3 complex subunit 1B	ISS	9618202	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00057	Wnt signaling pathway	P01456	beta-arrestin	BOVIN|Gene=ARR3|UniProtKB=Q9N0H5	Arrestin-C	IC	11742073	PubMed	PTHR11792:SF19	ARRESTIN-C
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=4404|UniProtKB=P59768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00049	Parkinson disease	P01211	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	MACMU|Ensembl=ENSMMUG00000004982|UniProtKB=F7AU14	Serine/threonine-protein kinase receptor	ISS	9395284	PubMed	PTHR23255:SF66	SERINE/THREONINE-PROTEIN KINASE RECEPTOR R3
P00012	Cadherin signaling pathway	P00467	alpha-catenin	MONDO|Ensembl=ENSMODG00000015456|UniProtKB=F6S406	Uncharacterized protein	ISS	1768802	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04393	Ras Pathway	P04561	SRF	MONDO|Ensembl=ENSMODG00000018981|UniProtKB=F7FP88	Uncharacterized protein	ISS	15326221	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P06664	Gonadotropin-releasing hormone receptor pathway	P06850	PKCs(3)	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	RCA	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04393	Ras Pathway	P04558	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04397	p53 pathway by glucose deprivation	P04640	p53	MOUSE|MGI=MGI=98834|UniProtKB=P02340	Cellular tumor antigen p53	TAS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CAEEL|WormBase=WBGene00001187|UniProtKB=Q8MQA1	Uncharacterized protein	IC	15737619	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=628675|UniProtKB=Q9Z2A6	Mitogen-activated protein kinase 15	IDA	9891064	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00009	Axon guidance mediated by netrin	P00366	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12176041	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00050	Plasminogen activating cascade	P01255	Plasminogen	RAT|RGD=619893|UniProtKB=Q01177	Plasminogen	IDA	16758216	gi	PTHR24261:SF5	PLASMINOGEN
P00046	Oxidative stress response	P01124	Myc	MACMU|Ensembl=ENSMMUG00000014601|UniProtKB=B8XIA5	Myc proto-oncogene protein	ISS	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DANRE|ZFIN=ZDB-GENE-030131-55|UniProtKB=Q6XNL8	Actin	IC	14684598	PubMed	PTHR11937:SF263	ACTIN
P00057	Wnt signaling pathway	P01428	Frizzled	DANRE|ZFIN=ZDB-GENE-990415-229|UniProtKB=Q8QFM3	Frizzled 7a	IDA	11212302	PubMed	PTHR11309:SF31	FRIZZLED-7
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	ISS	11535291	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00036	Interleukin signaling pathway	P00965	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00059	p53 pathway	G04694	p110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01242	Casein kinase I	HUMAN|HGNC=2455|UniProtKB=P78368	Casein kinase I isoform gamma-2	IDA	10617630	PubMed	PTHR11909:SF157	CASEIN KINASE I ISOFORM GAMMA-2
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014262|UniProtKB=F7BYS8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00006	Apoptosis signaling pathway	P00318	PKCs	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MACMU|Ensembl=ENSMMUG00000010440|UniProtKB=F7CRV6	Uncharacterized protein	ISS	12890691	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	CHICK|Ensembl=ENSGALG00000005621|UniProtKB=F1NGS8	Uncharacterized protein	ISS	10092204	PubMed	PTHR43940:SF5	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA
P00010	B cell activation	P00391	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01446	Calcineurin	TAKRU|Ensembl=ENSTRUG00000000891|UniProtKB=H2RPR0	Uncharacterized protein	ISS	12015605	PubMed	PTHR23056:SF4	PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00049	Parkinson disease	P01208	Hsp70	MOUSE|MGI=MGI=105384|UniProtKB=P63017	Heat shock cognate 71 kDa protein	IDA	12150907	PubMed	PTHR19375:SF239	HEAT SHOCK COGNATE 71 KDA PROTEIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00048	PI3 kinase pathway	P01198	FOXO	HUMAN|HGNC=3819|UniProtKB=Q12778	Forkhead box protein O1	ISS	10347145	PubMed	PTHR11829:SF159	FORKHEAD BOX PROTEIN O1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	14744428	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Ensembl=ENSBTAG00000006582|UniProtKB=E1BFV6	Uncharacterized protein	ISS	12181435	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00021	FGF signaling pathway	P00636	FGFR1-4	HUMAN|HGNC=3688|UniProtKB=P11362	Fibroblast growth factor receptor 1	IGI	9989949	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P00014	Cholesterol biosynthesis	P00499	Farnesyl-diphosphate farnesyltransferase	ORYSJ|EnsemblGenome=OS03G0805100|UniProtKB=O22105	Os03g0805100 protein	ISS			PTHR11626:SF2	SQUALENE SYNTHASE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00003	Alzheimer disease-amyloid secretase pathway	P00087	Fe65	CANLF|Ensembl=ENSCAFG00000006420|UniProtKB=E2QWV4	Uncharacterized protein	ISS	15115822	PubMed	PTHR14058:SF5	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1
P00006	Apoptosis signaling pathway	P00321	HSP70	ORNAN|Ensembl=ENSOANG00000013291|UniProtKB=F6S4U9	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00005	Angiogenesis	P00238	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P04393	Ras Pathway	P04570	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	PANTR|Ensembl=ENSPTRG00000011718|UniProtKB=H2QHJ5	Adenylate cyclase 3	ISS	12623444	PubMed	PTHR11920:SF291	ADENYLATE CYCLASE TYPE 3
P00048	PI3 kinase pathway	P01179	PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	RCA	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00565	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00029	Huntington disease	P00807	Actin	PHYPA|Gene=PHYPADRAFT_107830|UniProtKB=A9TBG2	Actin 7	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00906	Rap1	DANRE|ZFIN=ZDB-GENE-041024-1|UniProtKB=F1R684	Uncharacterized protein	ISS	8576107	PubMed	PTHR24070:SF200	RAS-RELATED PROTEIN RAP-2C
P00057	Wnt signaling pathway	P01465	Ggamma	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IDA	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04393	Ras Pathway	P04553	PAK	PANTR|Ensembl=ENSPTRG00000022187|UniProtKB=Q7YQL4	Serine/threonine-protein kinase PAK 3	ISS	7559398	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04393	Ras Pathway	P04568	MKK3/6	HUMAN|HGNC=6843|UniProtKB=P46734	Dual specificity mitogen-activated protein kinase kinase 3	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	DROME|FlyBase=FBgn0003687|UniProtKB=P20227	TATA-box-binding protein	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P04373	5HT1 type receptor mediated signaling pathway	P04407	K+ channel	DANRE|ZFIN=ZDB-GENE-040724-171|UniProtKB=Q5TZ59	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00034	Integrin signalling pathway	P00906	Rap1	DANRE|ZFIN=ZDB-GENE-040426-2818|UniProtKB=Q7SY59	RAP2B, member of RAS oncogene family	ISS	8576107	PubMed	PTHR24070:SF194	RAS-RELATED PROTEIN RAP-2B
P00011	Blood coagulation	P00443	Fibrin polymer cross-linked	PANTR|Ensembl=ENSPTRG00000016535|UniProtKB=H2QQB5	Uncharacterized protein	ISS	4503689	gi	PTHR19143:SF232	FIBRINOGEN ALPHA CHAIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00036	Interleukin signaling pathway	P00965	ERK	PANTR|Ensembl=ENSPTRG00000020224|UniProtKB=H2Q9G3	Mitogen-activated protein kinase 6	ISS	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	CAEEL|WormBase=WBGene00001985|UniProtKB=O02100	Presenilin hop-1	TAS	12834808	PubMed	PTHR10202:SF14	PRESENILIN HOP-1
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	CAEEL|WormBase=WBGene00004769|UniProtKB=P52166	Presenilin sel-12	TAS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P06959	CCKR signaling map	P07168	p66 SHC1	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	RCA	10400698	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01429	Axin	CHICK|Gene=AXIN1|UniProtKB=O42400	Axin-1	IDA	12356903	PubMed	PTHR10845:SF11	AXIN-1
P00046	Oxidative stress response	P01135	p38	CAEBR|Gene=CBG01555|UniProtKB=A8WRD7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00034	Integrin signalling pathway	P00916	Ras	BOVIN|Ensembl=ENSBTAG00000009778|UniProtKB=E1BMX0	Uncharacterized protein	ISS	3023884	PubMed	PTHR24070:SF186	GTPASE KRAS
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MACMU|Ensembl=ENSMMUG00000010266|UniProtKB=F6PV18	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P06959	CCKR signaling map	G07292	COX2	HUMAN|HGNC=9605|UniProtKB=P35354	Prostaglandin G/H synthase 2	RCA		PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00029	Huntington disease	P00805	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	CHLTR|EnsemblGenome=CT_445|UniProtKB=O84451	Glutamate--tRNA ligase	ISS			PTHR43311:SF2	GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED
P00006	Apoptosis signaling pathway	P00318	PKCs	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	TAS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	CANLF|Ensembl=ENSCAFG00000004090|UniProtKB=F1PNQ0	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF291	ADENYLATE CYCLASE TYPE 3
P00048	PI3 kinase pathway	P01185	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00005	Angiogenesis	P00224	PDGF	CHICK|Ensembl=ENSGALG00000009378|UniProtKB=Q9I946	Platelet-derived growth factor C	ISS			PTHR11633:SF5	PLATELET-DERIVED GROWTH FACTOR C
P00018	EGF receptor signaling pathway	P00545	JNK1-3	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	HUMAN|HGNC=9991|UniProtKB=Q08116	Regulator of G-protein signaling 1	IDA	8756726	PubMed	PTHR10845:SF34	REGULATOR OF G-PROTEIN SIGNALING 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00053	T cell activation	P01332	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	CAEEL|WormBase=WBGene00007969|UniProtKB=Q18496	Acetyl-coenzyme A synthetase	ISS			PTHR24095:SF244	ACETYL-COENZYME A SYNTHETASE
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	ANOGA|Gene=AgaP_AGAP009443|UniProtKB=Q5TXC3	AGAP009443-PA (Fragment)	ISS	94365697	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00022	General transcription by RNA polymerase I	P00656	PTRF	MOUSE|MGI=MGI=1277968|UniProtKB=O54724	Polymerase I and transcript release factor	ISS	603198	OMIM	PTHR15240:SF3	POLYMERASE I AND TRANSCRIPT RELEASE FACTOR
P00006	Apoptosis signaling pathway	P00269	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02783	Tryptophan biosynthesis	P03206	Anthranilate synthase	NEUCR|EnsemblGenome=EFNCRG00000000483|UniProtKB=P00908	Multifunctional tryptophan biosynthesis protein	RCA			PTHR43418:SF4	MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN
P00052	TGF-beta signaling pathway	P01275	P38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	TAS	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	RAT|RGD=2869|UniProtKB=P24062	Insulin-like growth factor 1 receptor	ISS	6754360	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	DROME|FlyBase=FBgn0046332|UniProtKB=P83101	Putative glycogen synthase kinase-3 homolog	ISS	21361340	gi	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	4506785	gi	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P05731	GABA-B receptor II signaling	P05753	Ca channel	BOVIN|Ensembl=ENSBTAG00000009835|UniProtKB=F1MR37	Uncharacterized protein	ISS	18021322	PubMed	PTHR10037:SF137	VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1G
P05916	Opioid prodynorphin pathway	P05999	provasopressin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04379	Beta3 adrenergic receptor signaling pathway	P04449	Beta3	HUMAN|HGNC=288|UniProtKB=P13945	Beta-3 adrenergic receptor	ISS	12063255	PubMed	PTHR24248:SF3	BETA-3 ADRENERGIC RECEPTOR
P00053	T cell activation	P01336	Jnk	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IGI	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CAEEL|WormBase=WBGene00003774|UniProtKB=G5EGQ9	NMDA class glutamate Receptor	IC	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05918	p38 MAPK pathway	P06021	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	10891487	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00054	Toll receptor signaling pathway	P01338	IkappaB	PANTR|Ensembl=ENSPTRG00000018219|UniProtKB=H2QT35	Uncharacterized protein	ISS			PTHR24118:SF37	NF-KAPPA-B INHIBITOR EPSILON
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05918	p38 MAPK pathway	P06031	p38alpha	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	RCA	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00049	Parkinson disease	P01211	ERK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IGI	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	USTMA|Gene=UMAG_03910|UniProtKB=A0A0D1DU81	Chromosome 11, whole genome shotgun sequence	ISS	7514101	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00011	Blood coagulation	P00414	Thrombin	HUMAN|HGNC=3535|UniProtKB=P00734	Prothrombin	IC	176930	OMIM	PTHR24254:SF10	PROTHROMBIN
P06212	DPP-SCW signaling pathway	P06272	DPP	DROME|FlyBase=FBgn0000490|UniProtKB=P07713	Protein decapentaplegic	IEA	9759503	PubMed	PTHR11848:SF234	PROTEIN DECAPENTAPLEGIC
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Ensembl=ENSBTAG00000037726|UniProtKB=P10895	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	7822322	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00012	Cadherin signaling pathway	P00470	F-actin	SCHPO|PomBase=SPBC32H8.12c|UniProtKB=P10989	Actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00036	Interleukin signaling pathway	P00973	PKB	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS			PTHR24356:SF310	SUBFAMILY NOT NAMED
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00005	Angiogenesis	P00243	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00830	Lipoxygenase	MOUSE|MGI=MGI=87997|UniProtKB=P39654	Arachidonate 15-lipoxygenase	TAS	12432925	PubMed	PTHR11771:SF33	ARACHIDONATE 15-LIPOXYGENASE
P00036	Interleukin signaling pathway	P00965	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P06959	CCKR signaling map	P07228	MAPK1/3	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	RCA	11546808	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02763	Peptidoglycan biosynthesis	P03087	Glutamate racemase	ECOLI|EcoGene=EG11204|UniProtKB=P22634	Glutamate racemase	ISS			PTHR21198:SF2	GLUTAMATE RACEMASE
P04397	p53 pathway by glucose deprivation	P04636	S6K	CANLF|Ensembl=ENSCAFG00000017679|UniProtKB=E2RMD8	Ribosomal protein S6 kinase	ISS	15116068	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00060	Ubiquitin proteasome pathway	P01491	E2	TAKRU|Ensembl=ENSTRUG00000008268|UniProtKB=H2T7P3	Uncharacterized protein	ISS			PTHR43898:SF6	UBIQUITIN-CONJUGATING ENZYME E2 B
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	XENTR|Xenbase=XB-GENE-480347|UniProtKB=Q6P640	Actin, alpha cardiac muscle 1	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	14526383	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00010	B cell activation	P00381	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05731	GABA-B receptor II signaling	P05755	Gbeta	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00059	p53 pathway	P01481	ATM/ATR	CANLF|Ensembl=ENSCAFG00000007863|UniProtKB=E2QXA4	Uncharacterized protein	ISS	10196661	PubMed	PTHR11139:SF69	SERINE/THREONINE-PROTEIN KINASE ATR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000000223|UniProtKB=F6XHK8	Uncharacterized protein	ISS	1608964	PubMed	PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P04398	p53 pathway feedback loops 2	P04665	AKT	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	ISS	12655147	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	DROME|FlyBase=FBgn0026379|UniProtKB=Q7KMQ6	IP16020p	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00059	p53 pathway	P01486	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000000985|UniProtKB=F6VRS9	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00047	PDGF signaling pathway	P01159	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01417	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00005	Angiogenesis	P00223	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01185	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00019	Endothelin signaling pathway	P00590	IP3 R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	IGI	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00559	MEK1-2	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00057	Wnt signaling pathway	P01438	PP2A	MACMU|Ensembl=ENSMMUG00000008205|UniProtKB=F7GWP9	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	ISS	10092233	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00048	PI3 kinase pathway	P01192	p110	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	1171954	gi	PTHR10048:SF14	PI-3 KINASE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	XENTR|Xenbase=XB-GENE-493937|UniProtKB=Q5M8T9	Actin, alpha 2, smooth muscle, aorta	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00021	FGF signaling pathway	P00633	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IGI	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00045	Notch signaling pathway	P01114	Ntm	CANLF|Ensembl=ENSCAFG00000010476|UniProtKB=F1PS94	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	RAT|RGD=3250|UniProtKB=P35465	Serine/threonine-protein kinase PAK 1	ISS	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00054	Toll receptor signaling pathway	P01358	ERK1	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	RCA	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00010	B cell activation	P00391	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	MACMU|Ensembl=ENSMMUG00000013797|UniProtKB=F6TDC4	Uncharacterized protein	ISS			PTHR10937:SF2	GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE  ISOMERIZING  1
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	RAT|RGD=3139|UniProtKB=Q29RW1	Myosin-4	ISS	89264452	PubMed	PTHR13140:SF657	MYOSIN-4
P05915	Opioid proenkephalin pathway	P05991	Enkephalin	HUMAN|HGNC=8820|UniProtKB=P01213	Proenkephalin-B	ISS	131330	OMIM	PTHR11438:SF4	PROENKEPHALIN-B
P00053	T cell activation	P01307	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	ORNAN|Ensembl=ENSOANG00000000818|UniProtKB=F6PLI7	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P04393	Ras Pathway	P04556	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02785	Valine biosynthesis	P03216	Acetolactate synthase	RAT|RGD=1307988|UniProtKB=D4ACG2	IlvB (Bacterial acetolactate synthase)-like (Predicted), isoform CRA_c	ISS			PTHR18968:SF155	ACETOLACTATE SYNTHASE-LIKE PROTEIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00020	FAS signaling pathway	P00596	Caspase6	CHICK|Ensembl=ENSGALG00000012186|UniProtKB=F1NEL6	Uncharacterized protein	IGI	11463840	PubMed	PTHR10454:SF164	CASPASE-6
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00037	Ionotropic glutamate receptor pathway	P01026	KA	PANTR|Ensembl=ENSPTRG00000013825|UniProtKB=H2RAK4	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00001	Adrenaline and noradrenaline biosynthesis	P00067	MAO	BOVIN|Gene=MAOB|UniProtKB=P56560	Amine oxidase [flavin-containing] B	ISS	8602220	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_58093|UniProtKB=C3Z4K3	Putative uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00059	p53 pathway	P01486	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	HUMAN|HGNC=6697|UniProtKB=O75197	Low-density lipoprotein receptor-related protein 5	IDA	11907044	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P05918	p38 MAPK pathway	P06018	MNK1	HUMAN|HGNC=7110|UniProtKB=Q9BUB5	MAP kinase-interacting serine/threonine-protein kinase 1	IDA	Q9BUB5	SPACC	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00983	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IC	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MACMU|Ensembl=ENSMMUG00000017237|UniProtKB=F7HBZ1	Regulator of G-protein signaling 2	ISS	8756726	PubMed	PTHR10845:SF43	REGULATOR OF G-PROTEIN SIGNALING 2
P04393	Ras Pathway	P04546	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	IDA	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04398	p53 pathway feedback loops 2	P04665	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00011	Blood coagulation	P00428	alpha2-antiplasmin	BOVIN|Ensembl=ENSBTAG00000020859|UniProtKB=P28800	Alpha-2-antiplasmin	ISS	1168249	gi	PTHR11461:SF20	ALPHA-2-ANTIPLASMIN
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1170702	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	ARATH|TAIR=AT5G09920|UniProtKB=O48890	DNA-directed RNA polymerase II subunit 4	ISS			PTHR21297:SF0	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB4
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00021	FGF signaling pathway	P00634	MEKK1-5	PANTR|Ensembl=ENSPTRG00000009518|UniProtKB=H2QDN0	Mitogen-activated protein kinase kinase kinase 3	ISS	8649450	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000019277|UniProtKB=H2QUQ1	Uncharacterized protein	ISS	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	RAT|RGD=1304887|UniProtKB=D3ZPL7	Down syndrome cell adhesion molecule-like 1 (Predicted)	ISS			PTHR44107:SF3	DOWN SYNDROME CELL ADHESION MOLECULE-LIKE PROTEIN 1
P00034	Integrin signalling pathway	P00907	ERK	CANLF|Ensembl=ENSCAFG00000012934|UniProtKB=F1P750	Uncharacterized protein	ISS			PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	ANOGA|EnsemblGenome=AGAP010172|UniProtKB=Q7PD38	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00547	PP2A	PHYPA|Gene=PHYPADRAFT_165449|UniProtKB=A9SKN8	Serine/threonine-protein phosphatase	ISS			PTHR11668:SF318	SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-4 CATALYTIC SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	HUMAN|HGNC=1389|UniProtKB=Q00975	Voltage-dependent N-type calcium channel subunit alpha-1B	IDA	14624853	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	RAT|RGD=2343|UniProtKB=P08483	Muscarinic acetylcholine receptor M3	TAS	8100450	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P05730	Endogenous cannabinoid signaling	P05748	mGluR	CANLF|Ensembl=ENSCAFG00000004381|UniProtKB=J9JH96	Uncharacterized protein	ISS	8314195	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	GIAIC|EnsemblGenome=GL50803_40817|UniProtKB=A8BV70	Actin related protein	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05918	p38 MAPK pathway	P06015	p38gamma	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	RCA	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00010	B cell activation	P00391	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MONDO|Ensembl=ENSMODG00000009540|UniProtKB=F7C435	Metalloendopeptidase (Fragment)	ISS	9759503	PubMed	PTHR43978:SF3	BONE MORPHOGENETIC PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	RAT|RGD=70958|UniProtKB=P19492	Glutamate receptor 3	ISS	10331083	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00046	Oxidative stress response	P01131	MKP5	ANOGA|EnsemblGenome=AGAP008228|UniProtKB=Q7PNB0	AGAP008228-PA	ISS			PTHR10159:SF493	DUAL SPECIFICITY PROTEIN PHOSPHATASE PPS1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	TAS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00010	B cell activation	P00391	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06758	DRD2	MOUSE|MGI=MGI=94924|UniProtKB=P61168	D(2) dopamine receptor	RCA	2039532	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00030	Hypoxia response via HIF activation	P00814	P300	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00005	Angiogenesis	P00234	Grb2	HUMAN|HGNC=4566|UniProtKB=P62993	Growth factor receptor-bound protein 2	RCA			PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00005	Angiogenesis	P00211	GSK3beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00053	T cell activation	P01332	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00321	HSP70	CHICK|Ensembl=ENSGALG00000011715|UniProtKB=Q7SX63	Heat shock protein 70	ISS	12150907	PubMed	PTHR19375:SF216	HEAT SHOCK-RELATED 70 KDA PROTEIN 2
P04376	5HT4 type receptor mediated signaling pathway	P04426	K+ channel	HUMAN|HGNC=6278|UniProtKB=O14649	Potassium channel subfamily K member 3	ISS	11875121	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00010	B cell activation	P00373	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05913	Enkephalin release	P05972	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00543	ERK1-2	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02770	Pyridoxal phosphate salvage pathway	P03120	Pyridoxamine-5-phosphate oxidase	ANOGA|EnsemblGenome=AGAP002227|UniProtKB=Q7QK95	AGAP002227-PA	ISS			PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00052	TGF-beta signaling pathway	P01284	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=94924|UniProtKB=P61168	D(2) dopamine receptor	IDA	1319557	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01067	AChE	BOVIN|Gene=ACHE|UniProtKB=P23795	Acetylcholinesterase	IC			PTHR43142:SF1	CARBOXYLIC ESTER HYDROLASE
P00021	FGF signaling pathway	P00627	ERK1-2	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF330	SUBFAMILY NOT NAMED
P00046	Oxidative stress response	P01135	p38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	TAS	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00021	FGF signaling pathway	P00626	Spry	HUMAN|HGNC=11269|UniProtKB=O43609	Protein sprouty homolog 1	ISS	98117253	PubMed	PTHR12365:SF10	PROTEIN SPROUTY HOMOLOG 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MONDO|Ensembl=ENSMODG00000006241|UniProtKB=F7FRY0	Ribosomal protein S6 kinase	ISS	15526037	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00006	Apoptosis signaling pathway	P00260	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00638	PLCgamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00021	FGF signaling pathway	P00640	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01428	Frizzled	PANTR|Ensembl=ENSPTRG00000020490|UniProtKB=H2R2C6	Frizzled homolog 6	ISS	8717036	PubMed	PTHR11309:SF75	FRIZZLED-6
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PHYPA|Gene=PHYPADRAFT_223212|UniProtKB=Q6TYR5	Beta-tubulin 3	ISS	12932731	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00564	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	8649368	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	HUMAN|HGNC=6854|UniProtKB=Q9Y2U5	Mitogen-activated protein kinase kinase kinase 2	NAS	21735556	gi	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04565	MKK4/7	MACMU|Ensembl=ENSMMUG00000019842|UniProtKB=F7FU91	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00728	RhoGEF	RAT|RGD=620951|UniProtKB=Q9Z1I6	Rho guanine nucleotide exchange factor 1	IDA	12024019	PubMed	PTHR12673:SF122	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 1
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	TAS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04392	P53 pathway feedback loops 1	G04685	p73DeltaN	MOUSE|MGI=MGI=1330810|UniProtKB=O88898	Tumor protein 63	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00005	Angiogenesis	P00194	Paxillin	DICDI|dictyBase=DDB_G0274109|UniProtKB=Q8MML5	Paxillin-B	ISS			PTHR24216:SF47	PAXILLIN-B
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00034	Integrin signalling pathway	P00951	Jnk	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00034	Integrin signalling pathway	P00924	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01235	Fyn kinase	HUMAN|HGNC=3955|UniProtKB=P42685	Tyrosine-protein kinase FRK	IDA			PTHR24418:SF296	TYROSINE-PROTEIN KINASE FRK
P00008	Axon guidance mediated by Slit/Robo	P00348	Robo	ORNAN|Ensembl=ENSOANG00000013804|UniProtKB=F7DL02	Uncharacterized protein	ISS			PTHR44096:SF1	ROUNDABOUT HOMOLOG 1
P00010	B cell activation	P00376	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P04398	p53 pathway feedback loops 2	P04668	p53	MACMU|Ensembl=ENSMMUG00000016466|UniProtKB=F7GBH1	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00019	Endothelin signaling pathway	P00566	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00005	Angiogenesis	P00238	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	9199552	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00049	Parkinson disease	P01214	CHIP	BOVIN|Ensembl=ENSBTAG00000019136|UniProtKB=E1B7G3	Uncharacterized protein	ISS	12150907	PubMed	PTHR44284:SF1	E3 UBIQUITIN-PROTEIN LIGASE CHIP
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=1762|UniProtKB=P22223	Cadherin-3	IDA	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	PANTR|Ensembl=ENSPTRG00000034379|UniProtKB=H2RDK4	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	MACMU|Ensembl=ENSMMUG00000018375|UniProtKB=F7H1D5	Neurogenic locus notch homolog protein 2 isoform 1 preproprotein	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00018	EGF receptor signaling pathway	P00564	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00048	PI3 kinase pathway	P01190	PDK1 ACT	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	15210700	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	TAS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00021	FGF signaling pathway	P00638	PLCgamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00047	PDGF signaling pathway	P01162	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	MACMU|Ensembl=ENSMMUG00000014627|UniProtKB=F7GNE4	Catenin beta-1	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	RAT|RGD=621060|UniProtKB=O88777	Presenilin-2	TAS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00226	Delta/Serrate	RAT|RGD=619931|UniProtKB=O70534	Delta-like 1 homolog (Drosophila)	ISS			PTHR24052:SF11	PROTEIN DELTA HOMOLOG 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	TRYB2|Gene=Tb10.6k15.2790|UniProtKB=Q38AI6	Mitogen-activated protein kinase	ISS			PTHR24055:SF178	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01198	FOXO	MOUSE|MGI=MGI=1891915|UniProtKB=Q9WVH3	Forkhead box protein O4	ISS			PTHR11829:SF188	FORKHEAD BOX PROTEIN O4
P00057	Wnt signaling pathway	P01443	Phospholipase C	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	CAEEL|WormBase=WBGene00000115|UniProtKB=P46562	Putative aldehyde dehydrogenase family 7 member A1 homolog	IC			PTHR43521:SF1	ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	ARATH|TAIR=AT1G13890|UniProtKB=Q9LMG8	Putative SNAP25 homologous protein SNAP30	ISS	12475239	PubMed	PTHR19305:SF7	SNAP25 HOMOLOGOUS PROTEIN SNAP30-RELATED
P00057	Wnt signaling pathway	P01428	Frizzled	DROME|FlyBase=FBgn0027343|UniProtKB=O77438	Frizzled-3	IDA	8717036	PubMed	PTHR11309:SF125	FRIZZLED-3
P00012	Cadherin signaling pathway	P00470	F-actin	MACMU|Ensembl=ENSMMUG00000012054|UniProtKB=F6TII3	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P04397	p53 pathway by glucose deprivation	P04641	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00644	p38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	IGI	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05730	Endogenous cannabinoid signaling	P05751	Galpha	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00010	B cell activation	P00367	NFAT	PANTR|Ensembl=ENSPTRG00000013628|UniProtKB=H2R4F5	Uncharacterized protein	ISS	12787506	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	PANTR|Ensembl=ENSPTRG00000034379|UniProtKB=H2RDK4	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P00038	JAK/STAT signaling pathway	P01031	PIAS	HUMAN|HGNC=2752|UniProtKB=O75925	E3 SUMO-protein ligase PIAS1	ISS	8682149	PubMed	PTHR10782:SF11	E3 SUMO-PROTEIN LIGASE PIAS1
P00034	Integrin signalling pathway	P00931	Integrin beta	BOVIN|Ensembl=ENSBTAG00000015910|UniProtKB=P53712	Integrin beta-1	IDA	10706722	PubMed	PTHR10082:SF28	INTEGRIN BETA-1
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_115291|UniProtKB=C3ZMR2	Putative uncharacterized protein	ISS			PTHR11937:SF359	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00927	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	TAKRU|Ensembl=ENSTRUG00000014763|UniProtKB=H2ULB2	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF728	MYOSIN HEAVY CHAIN, SKELETAL MUSCLE, ADULT
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P02749	Leucine biosynthesis	P02999	2-Isopropylmalate synthase	LEPIN|EnsemblGenome=LA_2202|UniProtKB=Q8F445	2-isopropylmalate synthase	ISS			PTHR10277:SF9	2-ISOPROPYLMALATE SYNTHASE 1, CHLOROPLASTIC-RELATED
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	ECOLI|EcoGene=EG13179|UniProtKB=P80668	Phenylacetaldehyde dehydrogenase	IC	14724059	PubMed	PTHR11699:SF222	PHENYLACETALDEHYDE DEHYDROGENASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DANRE|ZFIN=ZDB-GENE-040426-1178|UniProtKB=Q7SY24	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MOUSE|MGI=MGI=95823|UniProtKB=Q03391	Glutamate receptor ionotropic, NMDA 2D	IC	14698601	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	MOUSE|MGI=MGI=1860835|UniProtKB=Q9WTP7	GTP:AMP phosphotransferase AK3, mitochondrial	ISS			PTHR23359:SF68	GTP:AMP PHOSPHOTRANSFERASE AK3, MITOCHONDRIAL
P00005	Angiogenesis	P00237	FRP	RAT|RGD=61916|UniProtKB=Q08463	Frizzled-1	ISS	11212302	PubMed	PTHR11309:SF81	FRIZZLED-1
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	HUMAN|HGNC=11773|UniProtKB=P37173	TGF-beta receptor type-2	TAS	9395284	PubMed	PTHR23255:SF55	TGF-BETA RECEPTOR TYPE-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00057	Wnt signaling pathway	P01456	beta-arrestin	RAT|RGD=3619|UniProtKB=P15887	S-arrestin	IC	11742073	PubMed	PTHR11792:SF15	S-ARRESTIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	9860142	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00049	Parkinson disease	P01227	20S proteasome	MONDO|Ensembl=ENSMODG00000002034|UniProtKB=F6QW93	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF14	PROTEASOME SUBUNIT ALPHA TYPE-5
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	IC	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00012	Cadherin signaling pathway	P00466	EGFR	MOUSE|MGI=MGI=95410|UniProtKB=P70424	Receptor tyrosine-protein kinase erbB-2	ISS	94193007	PubMed	PTHR24416:SF137	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2
P00021	FGF signaling pathway	P00638	PLCgamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00640	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	CANLF|Ensembl=ENSCAFG00000003333|UniProtKB=F1PWT6	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00019	Endothelin signaling pathway	P00590	IP3 R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000023940|UniProtKB=F6RFW8	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P05913	Enkephalin release	P05977	G-Protein (s)	XENTR|Xenbase=XB-GENE-961282|UniProtKB=Q6DF43	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	9094314	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00047	PDGF signaling pathway	P01161	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	PANTR|Ensembl=ENSPTRG00000015576|UniProtKB=H2QNN3	Uncharacterized protein	ISS			PTHR45311:SF1	INTERLEUKIN-12 SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00053	T cell activation	P01315	Calcineurin	CANLF|Ensembl=ENSCAFG00000014818|UniProtKB=E2RJ59	Serine/threonine-protein phosphatase	ISS	12015605	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00970	Interleukin	CANLF|Ensembl=ENSCAFG00000002588|UniProtKB=F1PPR5	Uncharacterized protein	ISS			PTHR16922:SF0	INTERLEUKIN-11
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	12972619	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00012	Cadherin signaling pathway	P00463	betacatenin	ORNAN|Ensembl=ENSOANG00000006811|UniProtKB=F6WBD5	Uncharacterized protein	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	TAS	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00020	FAS signaling pathway	P00615	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=11431|UniProtKB=O14662	Syntaxin-16	IC			PTHR19957:SF83	SYNTAXIN-16
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	RAT|RGD=628837|UniProtKB=P60711	Actin, cytoplasmic 1	IDA	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P05913	Enkephalin release	P05978	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P02761	Pantothenate biosynthesis	P03069	2-Dehydropantoate reductase	YEAST|SGD=S000001105|UniProtKB=P38787	2-dehydropantoate 2-reductase	ISS			PTHR43765:SF2	2-DEHYDROPANTOATE 2-REDUCTASE-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	RAT|RGD=621060|UniProtKB=O88777	Presenilin-2	IDA	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00057	Wnt signaling pathway	P01465	Ggamma	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05734	Synaptic vesicle trafficking	P05777	Synaptophysin	XENTR|Xenbase=XB-GENE-943861|UniProtKB=F7DFQ7	Uncharacterized protein (Fragment)	ISS	313475	OMIM	PTHR10306:SF10	SYNAPTOPHYSIN
P00021	FGF signaling pathway	P00624	14-3-3	PANTR|Ensembl=ENSPTRG00000013529|UniProtKB=H2R8X6	Uncharacterized protein	ISS	1671102	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	IDA	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00049	Parkinson disease	P01236	Casein kinase II	ORYSJ|EnsemblGenome=OS07G0495100|UniProtKB=Q84RS4	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	MOUSE|MGI=MGI=109284|UniProtKB=Q61144	Presenilin-2	IDA	12885769	PubMed	PTHR10202:SF13	PRESENILIN-2
P05731	GABA-B receptor II signaling	P05755	Gbeta	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CAEBR|Gene=CBG17587|UniProtKB=A8XRA5	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT1G07880|UniProtKB=Q9LQQ9	Mitogen-activated protein kinase 13	IDA	12787066	PubMed	PTHR24055:SF185	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00005	Angiogenesis	P00206	Wnt	MOUSE|MGI=MGI=1261834|UniProtKB=O70283	Protein Wnt-2b	ISS	8717036	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	MOUSE|MGI=MGI=1345192|UniProtKB=Q9WVJ2	26S proteasome non-ATPase regulatory subunit 13	ISS	10225435	PubMed	PTHR10539:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13
P00047	PDGF signaling pathway	P01163	c-Jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DANRE|ZFIN=ZDB-GENE-040426-1178|UniProtKB=Q7SY24	Protein kinase C beta type	ISS	11880265	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00045	Notch signaling pathway	G01541	E(spl)-C genes	RAT|RGD=621405|UniProtKB=G3V7S6	Hairy/enhancer-of-split related with YRPW motif 2	ISS			PTHR10985:SF88	HAIRY/ENHANCER-OF-SPLIT RELATED WITH YRPW MOTIF PROTEIN 2
P00047	PDGF signaling pathway	P01171	PLCgamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00057	Wnt signaling pathway	P01446	Calcineurin	CHICK|Ensembl=ENSGALG00000023648|UniProtKB=Q6VN51	Protein phospatase 3 regulatory subunit B alpha isoform type 1	ISS	12015605	PubMed	PTHR23056:SF4	PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1
P00021	FGF signaling pathway	P00640	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IGI	10799299	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00056	VEGF signaling pathway	P01408	Akt/PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01332	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	MOUSE|MGI=MGI=109284|UniProtKB=Q61144	Presenilin-2	TAS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	15860573	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00047	PDGF signaling pathway	P01143	ERK	RAT|RGD=621505|UniProtKB=P0C865	Mitogen-activated protein kinase 7	ISS	15085193	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00057	Wnt signaling pathway	P01444	Wnt	ANOGA|EnsemblGenome=AGAP009731|UniProtKB=Q7PM77	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF98	PROTEIN WNT-RELATED
P00004	Alzheimer disease-presenilin pathway	P00114	actin	SCHMA|EnsemblGenome=Smp_161920|UniProtKB=G4VSW5	Putative actin	IDA	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04393	Ras Pathway	P04561	SRF	CANLF|Ensembl=ENSCAFG00000001829|UniProtKB=F1PH12	Uncharacterized protein	ISS	8660892	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00045	Notch signaling pathway	G01541	E(spl)-C genes	PANTR|Ensembl=ENSPTRG00000020364|UniProtKB=H2QWB8	Uncharacterized protein	ISS			PTHR10985:SF78	HAIRY/ENHANCER-OF-SPLIT RELATED WITH YRPW MOTIF PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95815|UniProtKB=P39087	Glutamate receptor ionotropic, kainate 2	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00018	EGF receptor signaling pathway	P00565	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00048	PI3 kinase pathway	P01179	PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05915	Opioid proenkephalin pathway	P05991	Enkephalin	MACMU|Ensembl=ENSMMUG00000006775|UniProtKB=F7H3N8	Uncharacterized protein	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P05913	Enkephalin release	P05972	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	14744463	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01390	TFIIA complex	ARATH|TAIR=AT1G07470|UniProtKB=Q93VP4	At1g07470/F22G5_13	ISS	600519	OMIM	PTHR12694:SF13	TFIIA-L3
P00006	Apoptosis signaling pathway	P00260	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	HUMAN|HGNC=3086|UniProtKB=O14641	Segment polarity protein dishevelled homolog DVL-2	TAS	11212302	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P00020	FAS signaling pathway	P00616	Nuclear Lamin	BRAFL|Gene=BRAFLDRAFT_121709|UniProtKB=C3ZXL7	Putative uncharacterized protein	ISS	11165516	PubMed	PTHR23239:SF234	LAMIN DM0-RELATED
P00053	T cell activation	P01333	cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00047	PDGF signaling pathway	P01151	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MACMU|Ensembl=ENSMMUG00000013665|UniProtKB=F7GFT1	Matrix metalloproteinase-14 preproprotein	ISS	12834808	PubMed	PTHR10201:SF24	MATRIX METALLOPROTEINASE-14
P00006	Apoptosis signaling pathway	P00269	MAPK	YEAST|SGD=S000003272|UniProtKB=P14681	Mitogen-activated protein kinase KSS1	ISS	12787066	PubMed	PTHR24055:SF338	MITOGEN-ACTIVATED PROTEIN KINASE KSS1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	TAS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00020	FAS signaling pathway	P00601	c-Jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00289	FAS	BOVIN|Ensembl=ENSBTAG00000010785|UniProtKB=P51867	Tumor necrosis factor receptor superfamily member 6	ISS	10327065	PubMed	PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04393	Ras Pathway	P04552	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00049	Parkinson disease	P01236	Casein kinase II	CHICK|Ensembl=ENSGALG00000006197|UniProtKB=P21868	Casein kinase II subunit alpha	IDA	10806215	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	XENTR|Xenbase=XB-GENE-481766|UniProtKB=F6TIF1	Uncharacterized protein	ISS	9783586	PubMed	PTHR10814:SF21	TRANSDUCIN-LIKE ENHANCER PROTEIN 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	TAS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	RAT|RGD=3188|UniProtKB=Q9QW30	Neurogenic locus notch homolog protein 2	IDA	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	ENTHI|EnsemblGenome=EHI_197840|UniProtKB=C4M8K6	Rho family GTPase	ISS	97082968	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00034	Integrin signalling pathway	P00924	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00585	ECE1-3	DROME|FlyBase=FBgn0031678|UniProtKB=Q9VMU6	LD31822p	ISS			PTHR11733:SF160	FI17316P1-RELATED
P04393	Ras Pathway	P04546	GSK3	RAT|RGD=620351|UniProtKB=P18265	Glycogen synthase kinase-3 alpha	IDA	14698990	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01286	TGFbeta	DANRE|ZFIN=ZDB-GENE-050221-7|UniProtKB=Q32PR5	Growth differentiation factor 9	ISS	9759503	PubMed	PTHR11848:SF19	GROWTH/DIFFERENTIATION FACTOR 9
P00055	Transcription regulation by bZIP transcription factor	P01392	TFIIH complex	NEUCR|EnsemblGenome=EFNCRG00000001651|UniProtKB=Q1K4W6	Transcription factor TFIIH subunit Tfb4	ISS			PTHR12831:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3
P00018	EGF receptor signaling pathway	P00543	ERK1-2	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00551	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	ANOGA|EnsemblGenome=AGAP001478|UniProtKB=Q7PXM3	AGAP001478-PA	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04586	ProTRH (Pro Thyrotropin-releasing Hormone)	RAT|RGD=3903|UniProtKB=P01150	Pro-thyrotropin-releasing hormone	ISS	2126343	PubMed	PTHR17530:SF2	PRO-THYROTROPIN-RELEASING HORMONE
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	RAT|RGD=67385|UniProtKB=Q8VGC3	Voltage-dependent L-type calcium channel subunit beta-2	IC	20088160	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PANTR|Ensembl=ENSPTRG00000027750|UniProtKB=H2QS82	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IC	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00029	Huntington disease	P00795	BDNF	MOUSE|MGI=MGI=88145|UniProtKB=P21237	Brain-derived neurotrophic factor	ISS	12117585	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00047	PDGF signaling pathway	P01159	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000022175|UniProtKB=F6XHY0	Phosphoinositide phospholipase C	ISS			PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	TAS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00018	EGF receptor signaling pathway	P00547	PP2A	BOVIN|Ensembl=ENSBTAG00000007061|UniProtKB=Q08DP7	Protein phosphatase 2, regulatory subunit B', beta isoform	ISS	10092233	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P02738	De novo purine biosynthesis	P02902	ADP reductase	DEIRA|EnsemblGenome=DR_2374|UniProtKB=Q9RRW1	Ribonucleoside-diphosphate reductase	ISS			PTHR43371:SF1	SUBFAMILY NOT NAMED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CHICK|Ensembl=ENSGALG00000002098|UniProtKB=F1P0L4	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	97449291	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00012	Cadherin signaling pathway	P00475	Frizzled	PANTR|Ensembl=ENSPTRG00000012813|UniProtKB=H2QJ90	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF31	FRIZZLED-7
P06959	CCKR signaling map	P07138	SHC1	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	RCA	11607835	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00047	PDGF signaling pathway	P01174	Rho	PANTR|Ensembl=ENSPTRG00000016497|UniProtKB=H2QQ97	Uncharacterized protein	ISS	8649427	PubMed	PTHR12552:SF5	RHO GTPASE-ACTIVATING PROTEIN 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	MACMU|Ensembl=ENSMMUG00000019261|UniProtKB=F6SIX4	Uncharacterized protein	ISS	10778855	PubMed	PTHR45047:SF2	COLLAGEN ALPHA-1 XII  CHAIN
P00023	General transcription regulation	P00669	TFIIEalpha	MOUSE|MGI=MGI=1921447|UniProtKB=Q9D0D5	General transcription factor IIE subunit 1	ISS	189962	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHICK|Ensembl=ENSGALG00000009621|UniProtKB=P60706	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01472	Histone deacetylase	XENTR|Xenbase=XB-GENE-479583|UniProtKB=F6ULG8	Histone deacetylase	ISS	12665570	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P00057	Wnt signaling pathway	P01443	Phospholipase C	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	TAS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	CANLF|Ensembl=ENSCAFG00000013143|UniProtKB=E2REE0	Uncharacterized protein	ISS			PTHR42884:SF12	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 7
P00057	Wnt signaling pathway	P01471	alpha-catenin	MOUSE|MGI=MGI=88274|UniProtKB=P26231	Catenin alpha-1	IDA	9362521	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P05731	GABA-B receptor II signaling	P05752	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	CANLF|Ensembl=ENSCAFG00000010476|UniProtKB=F1PS94	Uncharacterized protein	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	IXOSC|EnsemblGenome=ISCW009711|UniProtKB=B7Q3T6	THO complex subunit, putative	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	XENTR|Xenbase=XB-GENE-6469705|UniProtKB=Q6P8G3	Actin, alpha sarcomeric/skeletal	ISS	11889139	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00093	Tip60	CANLF|Ensembl=ENSCAFG00000001897|UniProtKB=E2RG71	Uncharacterized protein	ISS			PTHR12345:SF14	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	IC	1650351	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00705	Gsalpha	CHICK|Ensembl=ENSGALG00000007509|UniProtKB=F1NM72	Uncharacterized protein	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P05912	Dopamine receptor mediated signaling pathway	P05949	Grb2	XENTR|Xenbase=XB-GENE-6070000|UniProtKB=Q66II3	Growth factor receptor-bound protein 2	ISS	12748278	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00019	Endothelin signaling pathway	P00591	PLCbeta	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04393	Ras Pathway	P04572	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	14526383	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00054	Toll receptor signaling pathway	P01346	TLR	PANTR|Gene=TLR2|UniProtKB=B3Y613	Toll-like receptor 2	ISS			PTHR24365:SF17	TOLL-LIKE RECEPTOR 2
P00025	Hedgehog signaling pathway	P00692	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00627	ERK1-2	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	RAT|RGD=2739|UniProtKB=Q00961	Glutamate receptor ionotropic, NMDA 2C	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	ARATH|TAIR=AT1G04950|UniProtKB=Q9MAU3	Transcription initiation factor TFIID subunit 6	ISS	15220358	gi	PTHR10221:SF13	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BOVIN|Ensembl=ENSBTAG00000014614|UniProtKB=P62739	Actin, aortic smooth muscle	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P04395	Vasopressin synthesis	P04592	Exopeptidase	BOVIN|Ensembl=ENSBTAG00000016514|UniProtKB=P04836	Carboxypeptidase E	ISS	1778303	PubMed	PTHR11532:SF59	CARBOXYPEPTIDASE E
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01317	CD3 gamma	RAT|RGD=1307718|UniProtKB=Q64159	T-cell surface glycoprotein CD3 gamma chain	IGI	9886373	PubMed	PTHR10570:SF8	T-CELL SURFACE GLYCOPROTEIN CD3 GAMMA CHAIN
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	XENTR|Gene=wnt11b-1|UniProtKB=Q66II0	Protein Wnt-11b-1	ISS	11266476	PubMed	PTHR12027:SF34	PROTEIN WNT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	SCHPO|PomBase=SPAC17G8.14c|UniProtKB=P36582	Protein kinase C-like 1	TAS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	XENTR|Xenbase=XB-GENE-491618|UniProtKB=Q6P378	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00053	T cell activation	P01336	Jnk	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MOUSE|MGI=MGI=95822|UniProtKB=Q01098	Glutamate receptor ionotropic, NMDA 2C	ISS	11554549	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01417	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	RAT|RGD=1309329|UniProtKB=F1MAD0	Protein Lrp5	ISS	11029006	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00021	FGF signaling pathway	P00629	PP2A	ARATH|TAIR=AT5G55260|UniProtKB=P48528	Serine/threonine-protein phosphatase PP-X isozyme 2	ISS			PTHR11668:SF22	SERINE/THREONINE-PROTEIN PHOSPHATASE 4 CATALYTIC SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	IC	11554549	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00056	VEGF signaling pathway	P01421	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	RCA			PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01437	TCF	PANTR|Ensembl=ENSPTRG00000016352|UniProtKB=H2QQ05	Uncharacterized protein	ISS	11266476	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00012	Cadherin signaling pathway	P00470	F-actin	TRIVA|Gene=TVAG_337240|UniProtKB=P90623	Actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00025	Hedgehog signaling pathway	P00692	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DROME|FlyBase=FBgn0261854|UniProtKB=A1Z9X0	Atypical protein kinase C	ISS	3045562	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	HUMAN|HGNC=10430|UniProtKB=Q15418	Ribosomal protein S6 kinase alpha-1	ISS	12213813	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00053	T cell activation	P01332	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	TAS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04556	Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	IDA	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00006	Apoptosis signaling pathway	P00302	ATF	CANLF|Ensembl=ENSCAFG00000013332|UniProtKB=F1PCQ4	Uncharacterized protein	ISS	10664585	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00050	Plasminogen activating cascade	P01251	MMP-3	PANTR|Ensembl=ENSPTRG00000004220|UniProtKB=H2Q4N2	Matrix metallopeptidase 3 (Stromelysin 1, progelatinase)	ISS	3477804	PubMed	PTHR10201:SF215	STROMELYSIN-1
P00012	Cadherin signaling pathway	P00462	Casein kinase II	DANRE|ZFIN=ZDB-GENE-990415-29|UniProtKB=Q91398	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P05918	p38 MAPK pathway	P06031	p38alpha	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	RCA	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00020	FAS signaling pathway	P00605	Pro-Caspase7	MOUSE|MGI=MGI=109383|UniProtKB=P97864	Caspase-7	IGI	14583630	PubMed	PTHR10454:SF31	CASPASE-7
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00012	Cadherin signaling pathway	P00471	Cadherin	CAEEL|EnsemblGenome=WBGene00001475|UniProtKB=G5EDK5	FlaMIngo (Cadherin plus 7TM domain) homolog	IDA	8120095	PubMed	PTHR24026:SF51	PROTOCADHERIN-LIKE WING POLARITY PROTEIN STAN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	YEAST|SGD=S000000201|UniProtKB=P24583	Protein kinase C-like 1	IC	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00053	T cell activation	P01322	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	BOVIN|Ensembl=ENSBTAG00000034854|UniProtKB=F1N246	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02776	Serine glycine biosynthesis	P03159	Phosphoserine phosphatase	CAEEL|WormBase=WBGene00013379|UniProtKB=A0A061ACK7	Uncharacterized protein	ISS			PTHR43344:SF2	PHOSPHOSERINE PHOSPHATASE
P00057	Wnt signaling pathway	P01465	Ggamma	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	RCA	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	BOVIN|Ensembl=ENSBTAG00000007943|UniProtKB=A3KMV9	AZIN1 protein	ISS			PTHR11482:SF7	ANTIZYME INHIBITOR 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	IDA	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00010	B cell activation	P00373	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00780	Microtubule	MOUSE|MGI=MGI=107861|UniProtKB=Q7TMM9	Tubulin beta-2A chain	ISS	9454836	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00916	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	91232861	PubMed	PTHR24070:SF385	GTPASE HRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IDA	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P06587	Nicotine pharmacodynamics pathway	P06597	CDK5	MACMU|Ensembl=ENSMMUG00000020451|UniProtKB=F6VZU3	Uncharacterized protein	ISS	10604473,	PubMed	PTHR24056:SF46	CYCLIN-DEPENDENT-LIKE KINASE 5
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	ORNAN|Ensembl=ENSOANG00000010658|UniProtKB=F6V2V1	Uncharacterized protein	ISS	10480933	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00049	Parkinson disease	P01238	14-3-3	CIOIN|Ensembl=ENSCING00000008609|UniProtKB=F6TNW3	Uncharacterized protein	IDA	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00034	Integrin signalling pathway	P00928	alpha actinin	MONDO|Ensembl=ENSMODG00000010180|UniProtKB=F6SUP3	Uncharacterized protein	ISS	2116421	PubMed	PTHR43947:SF3	ALPHA-ACTININ-1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	IDA	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MACMU|Ensembl=ENSMMUG00000010266|UniProtKB=F6PV18	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00629	PP2A	XENTR|Xenbase=XB-GENE-957526|UniProtKB=K9J7P6	Uncharacterized protein	ISS	8703017	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00047	PDGF signaling pathway	P01174	Rho	XENTR|Ensembl=ENSXETG00000013666|UniProtKB=F6RTT3	Uncharacterized protein (Fragment)	ISS	8288572	PubMed	PTHR12659:SF4	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01455	Smad4	ORNAN|Ensembl=ENSOANG00000008117|UniProtKB=F7F4A2	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IPI	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00052	TGF-beta signaling pathway	P01284	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01171	PLCgamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00371	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00545	JNK1-3	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	NAS			PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00018	EGF receptor signaling pathway	P00564	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00840	GPRK	CANLF|Ensembl=ENSCAFG00000016388|UniProtKB=F6X9W7	Protein-serine/threonine kinase	ISS	12032308	PubMed	PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P00059	p53 pathway	P01486	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00045	Notch signaling pathway	P01103	Next	CANLF|Ensembl=ENSCAFG00000019633|UniProtKB=F1PDC7	Uncharacterized protein	ISS	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	CANLF|Gene=PSEN1|UniProtKB=Q6RH31	Presenilin-1	TAS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P02738	De novo purine biosynthesis	P02899	GMP synthase	BOVIN|Ensembl=ENSBTAG00000013013|UniProtKB=F1MC86	Uncharacterized protein	ISS			PTHR11922:SF2	GMP SYNTHASE  GLUTAMINE-HYDROLYZING
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	2837282	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IGI	12707323	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	BOVIN|Ensembl=ENSBTAG00000009269|UniProtKB=F1MCM2	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00951	Jnk	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00029	Huntington disease	P00807	Actin	MOUSE|MGI=MGI=2444552|UniProtKB=Q8BFZ3	Beta-actin-like protein 2	IDA	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	PANTR|Ensembl=ENSPTRG00000001749|UniProtKB=H2Q0Q4	Uncharacterized protein	ISS	14624853	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	BOVIN|Ensembl=ENSBTAG00000018777|UniProtKB=E1BHU9	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	RAT|RGD=621516|UniProtKB=G3V6P8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8686|UniProtKB=Q9Y5E8	Protocadherin beta-15	IDA	8120095	PubMed	PTHR24028:SF97	PROTOCADHERIN BETA-15
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00965	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IC	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00048	PI3 kinase pathway	P01179	PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00034	Integrin signalling pathway	P00916	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	TAS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00566	ERK	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	ISS	19114921	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	TAS	97320448	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	HUMAN|HGNC=1077|UniProtKB=O00238	Bone morphogenetic protein receptor type-1B	IDA			PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00551	Akt	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	IGI	12086862	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04558	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	IDA	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000004690|UniProtKB=Q5F3W3	Mitogen-activated protein kinase 6	ISS	8444355	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00006	Apoptosis signaling pathway	P00272	ASK1	HUMAN|HGNC=6857|UniProtKB=Q99683	Mitogen-activated protein kinase kinase kinase 5	IDA	12697749	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	CANLF|Ensembl=ENSCAFG00000012565|UniProtKB=F1PRW0	Uncharacterized protein	ISS	10505793	PubMed	PTHR10223:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	90172230	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00828	Galphai	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	RCA			PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00004	Alzheimer disease-presenilin pathway	P00178	BACE-1 pro-domain	BOVIN|Ensembl=ENSBTAG00000019365|UniProtKB=Q2HJ40	Beta-secretase 1	ISS	10531052	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	BOVIN|Ensembl=ENSBTAG00000004775|UniProtKB=F1MBY1	Uncharacterized protein	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	RAT|RGD=2028|UniProtKB=P38445	Activin receptor type-2B	TAS	9395284	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P00036	Interleukin signaling pathway	P00971	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8617307	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00034	Integrin signalling pathway	P00912	Arp2/3	HUMAN|HGNC=705|UniProtKB=O15144	Actin-related protein 2/3 complex subunit 2	IPI	10940259	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P06664	Gonadotropin-releasing hormone receptor pathway	P06786	ERK1/2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	RCA	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00036	Interleukin signaling pathway	P00967	c-fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00006	Apoptosis signaling pathway	P00268	GCK	RAT|RGD=1308199|UniProtKB=D3ZXB1	Mitogen-activated protein kinase kinase kinase kinase	ISS			PTHR24361:SF392	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 2
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01332	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	1170702	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00034	Integrin signalling pathway	P00909	ASAP1	MACMU|Ensembl=ENSMMUG00000012145|UniProtKB=F7GZM3	Uncharacterized protein	RCA			PTHR23180:SF192	ARF-GAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1
P00029	Huntington disease	P00782	alpha-Adaptin	PANTR|Ensembl=ENSPTRG00000011315|UniProtKB=H2R0B2	Uncharacterized protein	ISS	11532990	PubMed	PTHR22780:SF19	AP-2 COMPLEX SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=1305870|UniProtKB=F7EKI5	Protein Pcdh18	ISS	8120095	PubMed	PTHR24028:SF9	PROTOCADHERIN-18
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MACMU|Ensembl=ENSMMUG00000006492|UniProtKB=F7H998	Actin-related protein 2/3 complex subunit 3	ISS	12473693	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01143	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00568	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01428	Frizzled	CANLF|Ensembl=ENSCAFG00000013547|UniProtKB=E2QVP7	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF126	FRIZZLED-5
P00034	Integrin signalling pathway	P00920	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	IC	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00053	T cell activation	P01305	Calmodulin	TAKRU|Ensembl=ENSTRUG00000008685|UniProtKB=H2TXN3	Uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF326	CALMODULIN
P00005	Angiogenesis	P00203	Erk	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00001	Adrenaline and noradrenaline biosynthesis	P00064	NET	BOVIN|Gene=SLC6A2|UniProtKB=P51143	Sodium-dependent noradrenaline transporter	ISS	97248649	PubMed	PTHR11616:SF37	SODIUM-DEPENDENT NORADRENALINE TRANSPORTER
P00047	PDGF signaling pathway	P01146	Ikk	HUMAN|HGNC=5960|UniProtKB=O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	RCA			PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00054	Toll receptor signaling pathway	P01369	MKK1	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	RCA	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00054	Toll receptor signaling pathway	P01352	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	ANOGA|EnsemblGenome=AGAP006718|UniProtKB=Q7QI86	AGAP006718-PA	ISS	96032356	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P00057	Wnt signaling pathway	P01444	Wnt	PANTR|Ensembl=ENSPTRG00000019617|UniProtKB=Q2QLE7	Protein Wnt-2	ISS	11266476	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P02785	Valine biosynthesis	P03216	Acetolactate synthase	MYCTU|EnsemblGenome=Rv3470c|UniProtKB=O06335	Putative acetolactate synthase large subunit IlvB2	ISS			PTHR18968:SF116	ACETOLACTATE SYNTHASE ISOZYME 3 LARGE SUBUNIT
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	IDA	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00034	Integrin signalling pathway	P00906	Rap1	PANTR|Ensembl=ENSPTRG00000001102|UniProtKB=H2QZR9	RAP1A, member of RAS oncogene family	ISS	8576107	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P02746	Heme biosynthesis	P02979	porphobilinogen synthase	MOUSE|MGI=MGI=96853|UniProtKB=P10518	Delta-aminolevulinic acid dehydratase	ISS			PTHR11458:SF0	DELTA-AMINOLEVULINIC ACID DEHYDRATASE
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	ISS			PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	MOUSE|MGI=MGI=1921575|UniProtKB=Q6IRU5	Clathrin light chain B	ISS	11889126	PubMed	PTHR10639:SF2	CLATHRIN LIGHT CHAIN B
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CANLF|Gene=GRIN1|UniProtKB=Q5R1P0	Glutamate receptor ionotropic, NMDA 1	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00048	PI3 kinase pathway	P01177	P110ACT	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00107	kinesin	PANTR|Ensembl=ENSPTRG00000011148|UniProtKB=H2QGL3	Uncharacterized protein	ISS	11740561	PubMed	PTHR19959:SF125	KINESIN LIGHT CHAIN 3
P00012	Cadherin signaling pathway	P00470	F-actin	DICDI|dictyBase=DDB_G0269234|UniProtKB=P07830	Major actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	HUMAN|HGNC=132|UniProtKB=P60709	Actin, cytoplasmic 1	IC	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00038	JAK/STAT signaling pathway	P01027	STAT	RAT|RGD=3772|UniProtKB=P52631	Signal transducer and activator of transcription 3	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04393	Ras Pathway	P04570	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1170702	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00023	General transcription regulation	P00659	TFIIEbeta	MOUSE|MGI=MGI=1915403|UniProtKB=Q9D902	General transcription factor IIE subunit 2	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	MONDO|Ensembl=ENSMODG00000001807|UniProtKB=F6Y7R9	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01177	P110ACT	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	DROME|FlyBase=FBgn0000038|UniProtKB=P04755	Acetylcholine receptor subunit beta-like 1	IC	22213672	PubMed	PTHR18945:SF771	ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	IDA	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MACMU|Ensembl=ENSMMUG00000003405|UniProtKB=F7FE85	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF143	MATRILYSIN
P00047	PDGF signaling pathway	P01143	ERK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00049	Parkinson disease	P01238	14-3-3	CANLF|Ensembl=ENSCAFG00000003386|UniProtKB=F6Y478	Uncharacterized protein	ISS	5803227	gi	PTHR18860:SF3	14-3-3 PROTEIN THETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	HUMAN|HGNC=703|UniProtKB=Q92747	Actin-related protein 2/3 complex subunit 1A	ISS	12963527	gi	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	HUMAN|HGNC=1401|UniProtKB=Q02641	Voltage-dependent L-type calcium channel subunit beta-1	IC	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	IDA	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	ARATH|TAIR=AT4G10680|UniProtKB=O82494	Putative uncharacterized protein AT4g10680	ISS			PTHR11618:SF4	TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT
P00048	PI3 kinase pathway	P01178	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12748278	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	BOVIN|Ensembl=ENSBTAG00000000231|UniProtKB=F1MCE7	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	CANLF|Gene=MYH1|UniProtKB=Q076A6	Myosin-1	ISS	10938134	PubMed	PTHR13140:SF484	MYOSIN-1
P00025	Hedgehog signaling pathway	P00692	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00060	Ubiquitin proteasome pathway	P01492	E1	DANRE|ZFIN=ZDB-GENE-040426-2009|UniProtKB=F1RCA1	Uncharacterized protein	ISS			PTHR10953:SF144	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00539	14-3-3	CANLF|Ensembl=ENSCAFG00000009514|UniProtKB=F1PKW7	Uncharacterized protein	ISS	21864508	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00542	EGFR	MACMU|Ensembl=ENSMMUG00000001674|UniProtKB=F7G3H1	Receptor protein-tyrosine kinase	ISS	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=1748|UniProtKB=P12830	Cadherin-1	IDA	8120095	PubMed	PTHR24027:SF319	CADHERIN-1
P00005	Angiogenesis	P00210	eNOS	RAT|RGD=3186|UniProtKB=Q62600	Nitric oxide synthase, endothelial	ISS	9837777	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00049	Parkinson disease	P01211	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00038	JAK/STAT signaling pathway	P01031	PIAS	MACMU|Ensembl=ENSMMUG00000016733|UniProtKB=F6V666	Uncharacterized protein	ISS	8682149	PubMed	PTHR10782:SF10	E3 SUMO-PROTEIN LIGASE PIAS3
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00006	Apoptosis signaling pathway	P00260	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	DROME|FlyBase=FBgn0004647|UniProtKB=P07207	Neurogenic locus Notch protein	IDA	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P04393	Ras Pathway	P04543	MEKK1/4	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	IDA	8940199	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00047	PDGF signaling pathway	P01162	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	TAKRU|Ensembl=ENSTRUG00000004676|UniProtKB=H2SFB7	Uncharacterized protein	ISS	2187864	PubMed	PTHR11800:SF2	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04393	Ras Pathway	P04542	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00274	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00046	Oxidative stress response	P01131	MKP5	CAEEL|WormBase=WBGene00003043|UniProtKB=V6CIV8	Lateral-signal-Induced Phosphatase	ISS			PTHR10159:SF489	DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3
P00034	Integrin signalling pathway	P00936	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	IPI	129387	gi	PTHR10048:SF14	PI-3 KINASE
P00019	Endothelin signaling pathway	P00586	Gq	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	IDA	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DANRE|ZFIN=ZDB-GENE-050417-267|UniProtKB=F1QUN8	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF263	ACTIN
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00018	EGF receptor signaling pathway	P00561	STAT	HUMAN|HGNC=11362|UniProtKB=P42224	Signal transducer and activator of transcription 1-alpha/beta	IGI	14755057	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT1G07880|UniProtKB=Q9LQQ9	Mitogen-activated protein kinase 13	ISS	12787066	PubMed	PTHR24055:SF185	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00010	B cell activation	P00367	NFAT	BOVIN|Ensembl=ENSBTAG00000018270|UniProtKB=F1MGR9	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00046	Oxidative stress response	P01131	MKP5	ORNAN|Ensembl=ENSOANG00000001437|UniProtKB=F7GDU1	Uncharacterized protein	ISS	11856337	PubMed	PTHR10159:SF299	DUAL SPECIFICITY PROTEIN PHOSPHATASE 10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	MOUSE|MGI=MGI=108007|UniProtKB=P48543	G protein-activated inward rectifier potassium channel 3	IDA			PTHR11767:SF17	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 3
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Ensembl=ENSPTRG00000016548|UniProtKB=H2QQC5	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000025373|UniProtKB=F6ZZG9	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P04398	p53 pathway feedback loops 2	P04661	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00053	T cell activation	P01322	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02743	Formyltetrahydroformate biosynthesis	P02953	Cobalamin dependent homocysteine transmethylase	ARATH|TAIR=AT3G63250|UniProtKB=Q9M1W4	Homocysteine S-methyltransferase 2	ISS			PTHR21091:SF123	FI01821P
P04393	Ras Pathway	P04568	MKK3/6	CANLF|Ensembl=ENSCAFG00000018530|UniProtKB=F1PXD3	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P02738	De novo purine biosynthesis	P02902	ADP reductase	EMENI|EnsemblGenome=CADANIAG00002685|UniProtKB=Q5BHB3	Ribonucleotide reductase [Source:UniProtKB/TrEMBLAcc:Q9HEW8]	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00029	Huntington disease	P00790	beta-Tubulin	STRPU|EnsemblGenome=SPU_000062|UniProtKB=W4X9L8	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IDA	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	DANRE|ZFIN=ZDB-GENE-051202-2|UniProtKB=Q6ZM67	Uncharacterized protein	ISS	11554554	PubMed	PTHR44391:SF3	SUBFAMILY NOT NAMED
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MACMU|Ensembl=ENSMMUG00000019112|UniProtKB=F6T8S6	N-methyl D-aspartate receptor subtype 2B	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	BOVIN|Gene=ALDOB|UniProtKB=Q3T0S5	Fructose-bisphosphate aldolase B	ISS	8086469	PubMed	PTHR11627:SF2	FRUCTOSE-BISPHOSPHATE ALDOLASE B
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00035	Interferon-gamma signaling pathway	P00956	SOCS	CHICK|Ensembl=ENSGALG00000013731|UniProtKB=B2WUP2	Suppressor of cytokine signaling 6	ISS	15032587	PubMed	PTHR44562:SF1	SUPPRESSOR OF CYTOKINE SIGNALING 6
P04398	p53 pathway feedback loops 2	P04665	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04393	Ras Pathway	P04553	PAK	MONDO|Ensembl=ENSMODG00000005255|UniProtKB=F7G800	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00024	Glycolysis	P00677	Hexokinase	MOUSE|MGI=MGI=2384910|UniProtKB=Q91W97	Putative hexokinase HKDC1	RCA			PTHR19443:SF28	HEXOKINASE HKDC1-RELATED
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	IGI	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CHLRE|EnsemblGenome=CHLREDRAFT_193901|UniProtKB=Q9FXT7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00046	Oxidative stress response	P01135	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	TAS	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P02763	Peptidoglycan biosynthesis	P03085	N-acetylglucosamine-enoylpyruvoyl transferase	THEMA|EnsemblGenome=TM_0108|UniProtKB=Q9WXW3	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	ISS			PTHR43783:SF1	UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE
P02756	N-acetylglucosamine metabolism	P03041	Glucosamine-6-phosphate deaminase	PANTR|Ensembl=ENSPTRG00000016023|UniProtKB=H2QPE3	Glucosamine-6-phosphate isomerase	ISS			PTHR11280:SF9	GLUCOSAMINE-6-PHOSPHATE ISOMERASE 2
P02783	Tryptophan biosynthesis	P03208	Tryptophan synthase B	SULSO|EnsemblGenome=SSO0888|UniProtKB=P50383	Tryptophan synthase beta chain 1	ISS			PTHR43565:SF1	TRYPTOPHAN SYNTHASE BETA CHAIN
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	CAEEL|WormBase=WBGene00001679|UniProtKB=P17343	Guanine nucleotide-binding protein subunit beta-1	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01196	PDK1	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	15210700	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04452	proopiomelanocortin	PANTR|Ensembl=ENSPTRG00000011721|UniProtKB=H2R8Y3	Uncharacterized protein	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	6264430	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	TRIAD|EnsemblGenome=TriadG37105|UniProtKB=B3RJX8	Calmodulin	ISS	9753452	PubMed	PTHR23050:SF245	AT16150P-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00001	Adrenaline and noradrenaline biosynthesis	P00068	amine translocator	MOUSE|MGI=MGI=1336892|UniProtKB=O88576	Sodium-dependent neutral amino acid transporter B(0)AT3	IC	12719981	PubMed	PTHR11616:SF109	SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER B 0 AT3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00012	Cadherin signaling pathway	P00467	alpha-catenin	MOUSE|MGI=MGI=88275|UniProtKB=Q61301	Catenin alpha-2	ISS	1768802	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_94959|UniProtKB=C3XYC4	Putative uncharacterized protein	IDA	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CAEBR|Gene=CBG03145|UniProtKB=A8WSP3	Protein CBG03145	ISS	14684598	PubMed	PTHR11937:SF46	ALPHA-CENTRACTIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=3025|UniProtKB=P21917	D(4) dopamine receptor	IDA	2137198	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	MOUSE|MGI=MGI=97453|UniProtKB=P35454	Oxytocin-neurophysin 1	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00060	Ubiquitin proteasome pathway	P01490	E3	RAT|RGD=1310067|UniProtKB=F1M3F2	Protein Smurf2	ISS	11252892	PubMed	PTHR11254:SF300	E3 UBIQUITIN-PROTEIN LIGASE SMURF2
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00025	Hedgehog signaling pathway	P00692	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	ARATH|TAIR=AT5G39400|UniProtKB=Q9FLZ5	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN1	ISS			PTHR12305:SF80	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND PROTEIN-TYROSINE-PHOSPHATASE PTEN1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CAEEL|WormBase=WBGene00006454|UniProtKB=G5EEN8	AEX-4	IC			PTHR19305:SF10	AEX-4
P00029	Huntington disease	P00778	NMDA receptor	HUMAN|HGNC=16767|UniProtKB=Q8TCU5	Glutamate receptor ionotropic, NMDA 3A	IDA	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00005	Angiogenesis	P00235	c-Fos	MONDO|Ensembl=ENSMODG00000005927|UniProtKB=F6WX28	Uncharacterized protein	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	IC	1482697	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MACMU|Ensembl=ENSMMUG00000005186|UniProtKB=F7CYA2	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF42	REGULATOR OF G-PROTEIN SIGNALING 5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Gene=OPRM1|UniProtKB=Q5IS39	Mu-type opioid receptor	ISS	11259487	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	ORNAN|Ensembl=ENSOANG00000002406|UniProtKB=F7BAS2	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	RAT|RGD=2523|UniProtKB=P25115	D(1B) dopamine receptor	ISS	15328036	PubMed	PTHR43893:SF8	D 1B  DOPAMINE RECEPTOR
P00034	Integrin signalling pathway	P00943	Talin	ORNAN|Ensembl=ENSOANG00000007148|UniProtKB=F7CLM4	Uncharacterized protein	ISS	14702644	PubMed	PTHR19981:SF7	MESODERM DEVELOPMENT CANDIDATE 1-RELATED
P00057	Wnt signaling pathway	P01444	Wnt	CANLF|Ensembl=ENSCAFG00000008760|UniProtKB=E2RTG8	Protein Wnt	ISS	14644163	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00021	FGF signaling pathway	P00643	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00318	PKCs	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	7492337	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01211	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04542	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01464	Pygo	RAT|RGD=1594620|UniProtKB=F1M5T3	Protein Pygo1	ISS	11955446	PubMed	PTHR23194:SF3	PYGOPUS HOMOLOG 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00056	VEGF signaling pathway	P01421	Rac	MONDO|Ensembl=ENSMODG00000019894|UniProtKB=F6W5V4	Uncharacterized protein	ISS			PTHR23176:SF28	RHO GTPASE-ACTIVATING PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00053	T cell activation	P01300	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00796	Kainate receptor	MONDO|Ensembl=ENSMODG00000013079|UniProtKB=F7FB74	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00019	Endothelin signaling pathway	P00572	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02746	Heme biosynthesis	P02980	Coproporphyrinogen Oxidase (oxygen dependent)	YEAST|SGD=S000002451|UniProtKB=P11353	Oxygen-dependent coproporphyrinogen-III oxidase	ISS			PTHR10755:SF0	OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	RAT|RGD=71083|UniProtKB=P30940	5-hydroxytryptamine receptor 1F	ISS	12441358	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02734	Chorismate biosynthesis	P02870	3-Phosphoshikimate-1-carboxyvinyl transferase	BACSU|EnsemblGenome=BSU22600|UniProtKB=P20691	3-phosphoshikimate 1-carboxyvinyltransferase	ISS			PTHR21090:SF5	PENTAFUNCTIONAL AROM POLYPEPTIDE
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00047	PDGF signaling pathway	P01153	GSK3	ARATH|TAIR=AT4G00720|UniProtKB=Q96287	Shaggy-related protein kinase theta	ISS	7529201	PubMed	PTHR24057:SF19	SHAGGY-RELATED PROTEIN KINASE BETA-RELATED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00559	MEK1-2	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00025	Hedgehog signaling pathway	P00692	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P02738	De novo purine biosynthesis	P02900	AICAR transformylase	ECOLI|EcoGene=EG10795|UniProtKB=P15639	Bifunctional purine biosynthesis protein PurH	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00038	JAK/STAT signaling pathway	P01027	STAT	MONDO|Ensembl=ENSMODG00000014836|UniProtKB=F7D2D3	Signal transducer and activator of transcription	ISS	10835485	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P02783	Tryptophan biosynthesis	P03209	Anthranilate phosphoribosyl transferase	BACTN|EnsemblGenome=BT_0530|UniProtKB=Q8AAD5	Anthranilate phosphoribosyltransferase	ISS			PTHR43285:SF2	ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IDA	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00628	JNK1-3	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IGI	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01155	Jak	MOUSE|MGI=MGI=96628|UniProtKB=P52332	Tyrosine-protein kinase JAK1	ISS	9637709	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00021	FGF signaling pathway	P00633	Ras	DICDI|dictyBase=DDB_G0292998|UniProtKB=P32252	Ras-like protein rasB	ISS	93205383	PubMed	PTHR24070:SF206	RAS-LIKE PROTEIN RASB
P05915	Opioid proenkephalin pathway	P05994	G-protein	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00047	PDGF signaling pathway	P01154	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IGI	12464394	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00054	Toll receptor signaling pathway	P01375	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	10553940	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00015	Circadian clock system	G01501	cry	CANLF|Ensembl=ENSCAFG00000001797|UniProtKB=E2RMX4	Uncharacterized protein	ISS	10428031	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00018	EGF receptor signaling pathway	P00557	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00057	Wnt signaling pathway	P01457	GBeta	BOVIN|Ensembl=ENSBTAG00000006495|UniProtKB=P11017	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IDA	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00023	General transcription regulation	P00662	TFIIA complex	ARATH|TAIR=AT5G59230|UniProtKB=Q9FIF4	TFIIA-L3	ISS	600519	OMIM	PTHR12694:SF13	TFIIA-L3
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04665	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00012	Cadherin signaling pathway	P00475	Frizzled	XENTR|Xenbase=XB-GENE-487022|UniProtKB=F6SH04	Uncharacterized protein (Fragment)	ISS	8717036	PubMed	PTHR11309:SF34	FRIZZLED-2
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	CAEEL|WormBase=WBGene00001622|UniProtKB=Q22682	Putative sodium-dependent excitatory amino acid transporter glt-4	ISS	94365697	PubMed	PTHR11958:SF56	SODIUM-DEPENDENT EXCITATORY AMINO ACID TRANSPORTER GLT-4-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00217	STAT3	CHICK|Ensembl=ENSGALG00000003267|UniProtKB=Q6DV79	Signal transducer and activator of transcription 3	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05730	Endogenous cannabinoid signaling	P05751	Galpha	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02741	Flavin biosynthesis	P02936	FAD synthetase	DEIRA|EnsemblGenome=DR_1008|UniProtKB=Q9RVL9	Riboflavin biosynthesis protein	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P05731	GABA-B receptor II signaling	P05752	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04668	p53	HUMAN|HGNC=11998|UniProtKB=P04637	Cellular tumor antigen p53	TAS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=109248|UniProtKB=Q920H4	Muscarinic acetylcholine receptor M5	IDA			PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01298	NFkappaB	RAT|RGD=70498|UniProtKB=Q63369	Nuclear factor NF-kappa-B p105 subunit (Fragment)	ISS	11739545	PubMed	PTHR24169:SF9	NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	MOUSE|MGI=MGI=87941|UniProtKB=Q3UYH7	Beta-adrenergic receptor kinase 2	IDA			PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00381	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00779	TBP	PANTR|Ensembl=ENSPTRG00000018827|UniProtKB=H2RD22	Uncharacterized protein	ISS	600075	OMIM	PTHR10126:SF20	TATA-BOX-BINDING PROTEIN
P05730	Endogenous cannabinoid signaling	P05748	mGluR	HUMAN|HGNC=4597|UniProtKB=P41594	Metabotropic glutamate receptor 5	ISS	7476890	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00748	Gbeta5L	MACMU|Ensembl=ENSMMUG00000017374|UniProtKB=F7H6T7	Uncharacterized protein	ISS	10051575	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00056	VEGF signaling pathway	P01411	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	10477300	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00010	B cell activation	P00402	Jnk	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	CAEEL|WormBase=WBGene00002196|UniProtKB=P28548	Casein kinase II subunit beta	IDA	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04398	p53 pathway feedback loops 2	P04657	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12805548	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00012	Cadherin signaling pathway	P00475	Frizzled	XENTR|Xenbase=XB-GENE-484322|UniProtKB=F6RPG1	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF22	FRIZZLED-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00859	NFkappaB	HUMAN|HGNC=7795|UniProtKB=Q00653	Nuclear factor NF-kappa-B p100 subunit	ISS	12574369	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00965	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IC	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01153	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00021	FGF signaling pathway	P00644	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IGI	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00029	Huntington disease	P00807	Actin	DROME|FlyBase=FBgn0000046|UniProtKB=P10981	Actin-87E	IDA	14684598	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	TAS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	89186920	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00010	B cell activation	P00402	Jnk	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00049	Parkinson disease	P01208	Hsp70	SCHPO|PomBase=SPBC1709.05|UniProtKB=Q10284	Heat shock protein sks2	IDA	12150907	PubMed	PTHR19375:SF256	HSP70 PROTEIN-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P02759	Pyridoxal-5-phosphate biosynthesis	P03058	Phosphohydroxythreonine aminotransferase	CAEBR|Gene=CBG22021|UniProtKB=A8Y1C7	Phosphoserine aminotransferase	ISS			PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P00054	Toll receptor signaling pathway	P01375	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	DANRE|ZFIN=ZDB-GENE-030121-1|UniProtKB=Q801V3	Uncharacterized protein	ISS			PTHR11482:SF7	ANTIZYME INHIBITOR 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	BOVIN|Ensembl=ENSBTAG00000019076|UniProtKB=E1BA03	Uncharacterized protein	ISS			PTHR24361:SF182	SERINE/THREONINE-PROTEIN KINASE PAK 6
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000035697|UniProtKB=Q28024	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IDA	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	TAKRU|Ensembl=ENSTRUG00000014690|UniProtKB=H2UKR9	Uncharacterized protein	ISS	11861492	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00047	PDGF signaling pathway	P01143	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CAEEL|WormBase=WBGene00001187|UniProtKB=Q8MQA1	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	RAT|RGD=67399|UniProtKB=Q64716	Insulin receptor-related protein	ISS	6754360	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00054	Toll receptor signaling pathway	P01368	MKK2	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00881	ROCK	MACMU|Ensembl=ENSMMUG00000004656|UniProtKB=F6T5Y1	Uncharacterized protein	ISS	10779382	PubMed	PTHR22988:SF33	RHO-ASSOCIATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01435	SWI/SNF	ORNAN|Ensembl=ENSOANG00000014884|UniProtKB=F6WZ81	Uncharacterized protein	ISS	11532957	PubMed	PTHR12656:SF11	AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 1B
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00013	Cell cycle	P00478	Pre-replication Complex	PANTR|Ensembl=ENSPTRG00000018927|UniProtKB=H2QU67	Replication protein A3, 14kDa	ISS	8454588	PubMed	PTHR15114:SF1	REPLICATION PROTEIN A 14 KDA SUBUNIT
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IDA	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00717	Phosphorylase b	RAT|RGD=620687|UniProtKB=P09811	Glycogen phosphorylase, liver form	IDA	4318782	PubMed	PTHR11468:SF12	GLYCOGEN PHOSPHORYLASE, LIVER FORM
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IDA	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05915	Opioid proenkephalin pathway	P05994	G-protein	XENTR|Xenbase=XB-GENE-6050844|UniProtKB=F6WNJ9	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04393	Ras Pathway	P04556	Raf	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00029	Huntington disease	P00799	JNK-2	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00981	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	TAS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01135	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00019	Endothelin signaling pathway	P00586	Gq	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IGI	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	NEUCR|EnsemblGenome=EFNCRG00000000159|UniProtKB=F5HH30	Guanine nucleotide-binding protein beta subunit	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05918	p38 MAPK pathway	P06031	p38alpha	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	RCA	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02763	Peptidoglycan biosynthesis	P03083	UDP-N-acetylmuramoylalanine-D-glutamate ligase	BACSU|EnsemblGenome=BSU15200|UniProtKB=Q03522	UDP-N-acetylmuramoylalanine--D-glutamate ligase	ISS			PTHR43692:SF1	UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	CAEBR|Gene=CBG01937|UniProtKB=A8WRM3	Protein CBR-CBS-2	ISS			PTHR10314:SF8	CYSTATHIONINE BETA-SYNTHASE-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00644	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	ISS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00048	PI3 kinase pathway	P01199	Galpha	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00006	Apoptosis signaling pathway	P00269	MAPK	ORYSJ|EnsemblGenome=OS02G0148100|UniProtKB=Q6Z437	Mitogen-activated protein kinase 3	ISS	6491800	gi	PTHR24055:SF216	SUBFAMILY NOT NAMED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	RAT|RGD=2257|UniProtKB=P62161	Calmodulin	ISS	9753452	PubMed	PTHR23050:SF311	CALMODULIN
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	13430383	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000000223|UniProtKB=F6XHK8	Uncharacterized protein	ISS	12181435	PubMed	PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P00049	Parkinson disease	P01212	p38 MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04393	Ras Pathway	P04570	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	ISS	1333286	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	MOUSE|MGI=MGI=1351339|UniProtKB=Q14BI2	Metabotropic glutamate receptor 2	ISS	12488551	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04393	Ras Pathway	P04543	MEKK1/4	MONDO|Ensembl=ENSMODG00000006594|UniProtKB=F7AKA6	Uncharacterized protein	ISS	602425	OMIM	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00048	PI3 kinase pathway	P01182	Ras	CAEBR|Gene=CBG06092|UniProtKB=A8X0X5	Protein CBR-LET-60	ISS	12024031	PubMed	PTHR24070:SF385	GTPASE HRAS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00572	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IGI	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00644	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	ISS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2743|UniProtKB=P31421	Metabotropic glutamate receptor 2	IDA	20012997	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	XENTR|Xenbase=XB-GENE-491121|UniProtKB=Q6P367	Tubulin, beta 2B	ISS	12932731	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	ARATH|TAIR=AT3G66658|UniProtKB=Q0WSF1	Aldehyde dehydrogenase 22A1	IC			PTHR11699:SF25	ALDEHYDE DEHYDROGENASE-LIKE PROTEIN YHR039C-RELATED
P00021	FGF signaling pathway	P00627	ERK1-2	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IGI	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00059	p53 pathway	P04609	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00007	Axon guidance mediated by semaphorins	P00340	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00048	PI3 kinase pathway	P01199	Galpha	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	IC	9009705	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00875	GEF	PANTR|Ensembl=ENSPTRG00000011238|UniProtKB=H2QGR4	Uncharacterized protein	ISS	11747824	PubMed	PTHR43935:SF4	CYTOHESIN-2
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	ECOLI|EcoGene=EG13766|UniProtKB=P77674	Gamma-aminobutyraldehyde dehydrogenase	IC	14724059	PubMed	PTHR11699:SF109	GAMMA-AMINOBUTYRALDEHYDE DEHYDROGENASE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MACMU|Ensembl=ENSMMUG00000031822|UniProtKB=F7H9S4	Activin beta-C chain	ISS	9759503	PubMed	PTHR11848:SF130	INHIBIN BETA C CHAIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	RCA	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00012	Cadherin signaling pathway	P00465	TCF/LEF	MONDO|Ensembl=ENSMODG00000020603|UniProtKB=F6ZBJ4	Uncharacterized protein	ISS	9039917	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00046	Oxidative stress response	P01135	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00006	Apoptosis signaling pathway	P00303	c-Jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04451	CRHR1	CANLF|Ensembl=ENSCAFG00000003097|UniProtKB=E2R4R1	Uncharacterized protein	ISS	11145609	PubMed	PTHR12011:SF274	CORTICOTROPIN-RELEASING FACTOR RECEPTOR 2
P02757	O-antigen biosynthesis	P03046	dTDP-glucose pyrophosphorylase	BACTN|EnsemblGenome=BT_0463|UniProtKB=Q8AAK1	Glucose-1-phosphate thymidylyltransferase	ISS			PTHR43532:SF3	GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE 2
P00057	Wnt signaling pathway	P01457	GBeta	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00006	Apoptosis signaling pathway	P00269	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00057	Wnt signaling pathway	P01435	SWI/SNF	MOUSE|MGI=MGI=1933623|UniProtKB=Q61466	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1	IDA	11532957	PubMed	PTHR13844:SF1	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D MEMBER 1
P00021	FGF signaling pathway	P00629	PP2A	MACMU|Ensembl=ENSMMUG00000013416|UniProtKB=F6Z2Q9	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B	ISS	7918404	PubMed	PTHR11871:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B GAMMA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	TETTS|EnsemblGenome=TTHERM_00630500|UniProtKB=Q241P0	Calmodulin 1	ISS			PTHR23050:SF245	AT16150P-RELATED
P00036	Interleukin signaling pathway	P00968	Ikk	RAT|RGD=1306661|UniProtKB=G3V926	Conserved helix-loop-helix ubiquitous kinase (Predicted)	ISS	14499113	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00021	FGF signaling pathway	P00648	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	HUMAN|HGNC=7573|UniProtKB=P11055	Myosin-3	ISS	89264452	PubMed	PTHR13140:SF427	MYOSIN-3
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DROME|FlyBase=FBgn0259680|UniProtKB=P83099	Putative protein kinase C delta type homolog	IC	2837282	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DANRE|ZFIN=ZDB-GENE-041210-195|UniProtKB=F1R506	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00034	Integrin signalling pathway	P00927	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04393	Ras Pathway	P04548	ATF2	CANLF|Ensembl=ENSCAFG00000013332|UniProtKB=F1PCQ4	Uncharacterized protein	ISS	11390664	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00059	p53 pathway	P04633	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00020	FAS signaling pathway	P00620	CytochromeC	ARATH|TAIR=AT3G27240|UniProtKB=Q9LK29	Cytochrome c1 1, heme protein, mitochondrial	ISS	15163634	PubMed	PTHR10266:SF6	CYTOCHROME C1 1, HEME PROTEIN, MITOCHONDRIAL-RELATED
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	METAC|EnsemblGenome=MA_4079|UniProtKB=Q8TIR3	Aldehyde dehydrogenase (NAD(P)+)	IC			PTHR43521:SF2	DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 12A1, MITOCHONDRIAL
P00047	PDGF signaling pathway	P01152	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	227170	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	BRAFL|Gene=BRAFLDRAFT_128184|UniProtKB=C4A0B6	Tyrosine-protein kinase receptor	ISS	11182407	gi	PTHR24416:SF402	INSULIN RECEPTOR
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00050	Plasminogen activating cascade	P01256	uPAR	HUMAN|HGNC=9053|UniProtKB=Q03405	Urokinase plasminogen activator surface receptor	IEA	1689240	PubMed	PTHR10624:SF6	UROKINASE PLASMINOGEN ACTIVATOR SURFACE RECEPTOR
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04397	p53 pathway by glucose deprivation	P04640	p53	MACMU|Ensembl=ENSMMUG00000016466|UniProtKB=F7GBH1	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00047	PDGF signaling pathway	P01171	PLCgamma	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00021	FGF signaling pathway	P00645	Rac	ENTHI|EnsemblGenome=EHI_197840|UniProtKB=C4M8K6	Rho family GTPase	ISS	97082968	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00009	Axon guidance mediated by netrin	P00363	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	ISS	1171954	gi	PTHR10048:SF14	PI-3 KINASE
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00010	B cell activation	P00402	Jnk	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00029	Huntington disease	P00775	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12912997	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-486685|UniProtKB=F6VT32	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	RAT|RGD=1307015|UniProtKB=D3ZRW5	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00006	Apoptosis signaling pathway	P00257	Bcl-xL	PANTR|Ensembl=ENSPTRG00000013359|UniProtKB=H2QK53	BCL2-like 1	ISS	7828536	PubMed	PTHR11256:SF12	BCL-2-LIKE PROTEIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00011	Blood coagulation	P00414	Thrombin	RAT|RGD=61996|UniProtKB=P18292	Prothrombin	ISS	12621076	gi	PTHR24254:SF10	PROTHROMBIN
P02741	Flavin biosynthesis	P02939	Lumazine synthase	AQUAE|EnsemblGenome=aq_132|UniProtKB=O66529	6,7-dimethyl-8-ribityllumazine synthase	ISS			PTHR21058:SF0	6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05915	Opioid proenkephalin pathway	P05994	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	HUMAN|HGNC=7569|UniProtKB=P35749	Myosin-11	ISS	89264452	PubMed	PTHR13140:SF335	MYOSIN-11
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00010	B cell activation	P00371	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MONDO|Ensembl=ENSMODG00000004799|UniProtKB=F6VM87	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00059	p53 pathway	P04610	Cyclin E	MOUSE|MGI=MGI=88316|UniProtKB=Q61457	G1/S-specific cyclin-E1	ISS	12628165	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	98189216	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000005791|UniProtKB=F6UB42	Uncharacterized protein	ISS			PTHR15593:SF1	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00859	NFkappaB	CANLF|Ensembl=ENSCAFG00000013334|UniProtKB=F1PCU1	Uncharacterized protein	RCA			PTHR24169:SF1	TRANSCRIPTION FACTOR P65
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00297	NFkappaB	PANTR|Ensembl=ENSPTRG00000002888|UniProtKB=H2Q2H2	Uncharacterized protein	ISS	9133421	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00012	Cadherin signaling pathway	P00475	Frizzled	MOUSE|MGI=MGI=108476|UniProtKB=Q61086	Frizzled-3	IDA	12549854	PubMed	PTHR11309:SF22	FRIZZLED-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00029	Huntington disease	P00778	NMDA receptor	MOUSE|MGI=MGI=95819|UniProtKB=P35438	Glutamate receptor ionotropic, NMDA 1	IDA	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	XENTR|Xenbase=XB-GENE-957248|UniProtKB=Q6GLE6	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00035	Interferon-gamma signaling pathway	P00960	PTP	PANTR|Ensembl=ENSPTRG00000042397|UniProtKB=H2RIH8	Tyrosine-protein phosphatase non-receptor type	ISS	7681589	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00034	Integrin signalling pathway	P00944	Actin	MONDO|Ensembl=ENSMODG00000025373|UniProtKB=F6ZZG9	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P04393	Ras Pathway	P04552	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	IDA	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00049	Parkinson disease	P01211	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04569	Cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	HUMAN|HGNC=19260|UniProtKB=Q9NPC1	Leukotriene B4 receptor 2	ISS	10048442	gi	PTHR24230:SF8	LEUKOTRIENE B4 RECEPTOR 2
P05917	Opioid proopiomelanocortin pathway	P06009	K+ channel	MONDO|Ensembl=ENSMODG00000015769|UniProtKB=F6ZSC2	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	RAT|RGD=1311791|UniProtKB=Q4KLF8	Actin-related protein 2/3 complex subunit 5	ISS	12932731	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00046	Oxidative stress response	P01136	Elk-1	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	11151091	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P04393	Ras Pathway	P04542	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00036	Interleukin signaling pathway	P00997	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P05913	Enkephalin release	G06045	preproenkephalin	HUMAN|HGNC=8831|UniProtKB=P01210	Proenkephalin-A	IC	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00011	Blood coagulation	P00418	Fibrin monomer	RAT|RGD=2603|UniProtKB=P06399	Fibrinogen alpha chain	ISS	1706800	gi	PTHR19143:SF232	FIBRINOGEN ALPHA CHAIN
P00048	PI3 kinase pathway	P01199	Galpha	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00006	Apoptosis signaling pathway	P00317	Fos	MONDO|Ensembl=ENSMODG00000005927|UniProtKB=F6WX28	Uncharacterized protein	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IPI	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00029	Huntington disease	P00778	NMDA receptor	BOVIN|Ensembl=ENSBTAG00000000219|UniProtKB=F1MCL3	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00009	Axon guidance mediated by netrin	P00357	Netrin	MOUSE|MGI=MGI=105088|UniProtKB=O09118	Netrin-1	ISS	9427245	PubMed	PTHR10574:SF365	NETRIN-1
P00029	Huntington disease	P00807	Actin	CANLF|Ensembl=ENSCAFG00000012181|UniProtKB=F2Z4N7	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	BOVIN|Ensembl=ENSBTAG00000000219|UniProtKB=F1MCL3	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	DROME|FlyBase=FBgn0001961|UniProtKB=O97182	Actin related complex p41 subunit	ISS	12963527	gi	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P00005	Angiogenesis	P00252	Grb2	MACMU|Ensembl=ENSMMUG00000005327|UniProtKB=F7GJG7	GRB2-related adapter protein	ISS			PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TRIAD|EnsemblGenome=TriadG63375|UniProtKB=B3S5E4	Non-muscle actin 6.2	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00046	Oxidative stress response	P01122	TRX	DROME|FlyBase=FBgn0036442|UniProtKB=Q9VUG9	IP04051p	TAS	12115731	PubMed	PTHR10438:SF359	THIOREDOXIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BOVIN|Ensembl=ENSBTAG00000006189|UniProtKB=P63258	Actin, cytoplasmic 2	ISS	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00046	Oxidative stress response	P01135	p38	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	4506785	gi	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	RAT|RGD=61858|UniProtKB=P70507	G protein-coupled receptor kinase 4	RCA			PTHR24355:SF14	G PROTEIN-COUPLED RECEPTOR KINASE 4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	TAS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04397	p53 pathway by glucose deprivation	P04639	AMPK	MACMU|Ensembl=ENSMMUG00000012221|UniProtKB=F6VMA7	5'-AMP-activated protein kinase subunit beta-2	ISS			PTHR10343:SF45	5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2
P00059	p53 pathway	P04633	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00922	Collagen	MOUSE|MGI=MGI=88461|UniProtKB=E9PWQ3	Protein Col6a3	IDA	10778855	PubMed	PTHR44105:SF2	COLLAGEN ALPHA-3 VI  CHAIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	IC	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P05917	Opioid proopiomelanocortin pathway	P06010	proopiomelanocortin	DANRE|ZFIN=ZDB-GENE-030513-2|UniProtKB=Q7ZT18	Pro-opiomelanocortin protein	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	PANTR|Ensembl=ENSPTRG00000018764|UniProtKB=H2QU01	Uncharacterized protein	ISS	11081635	PubMed	PTHR15071:SF17	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00048	PI3 kinase pathway	P01185	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MACMU|Ensembl=ENSMMUG00000007610|UniProtKB=F6SDH6	Ribosomal protein S6 kinase	ISS	9792677	PubMed	PTHR24351:SF41	RIBOSOMAL PROTEIN S6 KINASE ALPHA-4
P05918	p38 MAPK pathway	P06041	Cdc42	CHICK|Ensembl=ENSGALG00000004796|UniProtKB=Q90694	Cell division control protein 42 homolog	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	10553940	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00049	Parkinson disease	P01242	Casein kinase I	CAEBR|Gene=CBG09510|UniProtKB=A8X8Y1	Protein CBG09510	ISS	10617630	PubMed	PTHR11909:SF19	ASATOR, ISOFORM D
P00015	Circadian clock system	P00505	Cry	CANLF|Ensembl=ENSCAFG00000009379|UniProtKB=F1PNC9	Uncharacterized protein	ISS	14507900	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00057	Wnt signaling pathway	P01443	Phospholipase C	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	CAEEL|WormBase=WBGene00000068|UniProtKB=Q19523	Adenylyl CYclase	IGI	2491850	PubMed	PTHR11920:SF319	ADENYLATE CYCLASE TYPE 9
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	CANLF|Ensembl=ENSCAFG00000004956|UniProtKB=E2REH3	Uncharacterized protein	ISS	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00047	PDGF signaling pathway	P01174	Rho	PANTR|Ensembl=ENSPTRG00000005134|UniProtKB=H2Q6B4	Uncharacterized protein	ISS	8288572	PubMed	PTHR23181:SF4	RHO GTPASE-ACTIVATING PROTEIN 9
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	ANOGA|EnsemblGenome=AGAP003718|UniProtKB=Q7QG26	AGAP003718-PA	IDA	8756726	PubMed	PTHR10845:SF151	LP21163P
P04397	p53 pathway by glucose deprivation	P04640	p53	MACMU|Ensembl=ENSMMUG00000008639|UniProtKB=P56424	Cellular tumor antigen p53	TAS	11313951	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00034	Integrin signalling pathway	P00920	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00010	B cell activation	P00398	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IGI	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00048	PI3 kinase pathway	P01202	p85	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00019	Endothelin signaling pathway	P00568	PKC	SCHPO|PomBase=SPBC12D12.04c|UniProtKB=P36583	Protein kinase C-like 2	IGI	125549	gi	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00059	p53 pathway	P04626	GADD45	PANTR|Ensembl=ENSPTRG00000024024|UniProtKB=H2R6I0	Growth arrest and DNA-damage-inducible, beta	ISS	10097101	PubMed	PTHR10411:SF5	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 BETA
P00049	Parkinson disease	P01211	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1712|UniProtKB=Q6PBY0	Guanine nucleotide binding protein (G protein), beta 5	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P05917	Opioid proopiomelanocortin pathway	P06007	alpha-MSH	XENTR|Xenbase=XB-GENE-483703|UniProtKB=Q5M8F2	Proopiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CAEEL|WormBase=WBGene00012437|UniProtKB=Q9XWR0	Heavy chain, Unconventional Myosin	IC			PTHR13140:SF388	COILED-COIL DOMAIN-CONTAINING PROTEIN 171
P04393	Ras Pathway	P04561	SRF	MACMU|Ensembl=ENSMMUG00000000033|UniProtKB=F7G4D2	Uncharacterized protein	ISS	15326221	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	RAT|RGD=1307535|UniProtKB=G3V928	Protein Lrp1	ISS	11907044	PubMed	PTHR44025:SF2	PROLOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	TAS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00052	TGF-beta signaling pathway	P01279	Smurfs	ORNAN|Ensembl=ENSOANG00000008046|UniProtKB=F7EF57	Uncharacterized protein	ISS	11252892	PubMed	PTHR11254:SF300	E3 UBIQUITIN-PROTEIN LIGASE SMURF2
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00030	Hypoxia response via HIF activation	P00819	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02761	Pantothenate biosynthesis	P03068	Pantoate-beta-alanine ligase	AQUAE|EnsemblGenome=aq_2132|UniProtKB=O67891	Pantothenate synthetase	ISS			PTHR21299:SF1	PANTOATE--BETA-ALANINE LIGASE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	BOVIN|Ensembl=ENSBTAG00000020458|UniProtKB=A2VE18	STX6 protein	ISS	10839363	PubMed	PTHR19957:SF104	SYNTAXIN-6
P02741	Flavin biosynthesis	P02939	Lumazine synthase	YEAST|SGD=S000005503|UniProtKB=P50861	6,7-dimethyl-8-ribityllumazine synthase	ISS			PTHR21058:SF0	6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00058	mRNA splicing	P01473	U6	CANLF|Ensembl=ENSCAFG00000011820|UniProtKB=E2R4I0	Uncharacterized protein	ISS	9328476	PubMed	PTHR14212:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	RAT|RGD=1597195|UniProtKB=D4A9J2	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00047	PDGF signaling pathway	P01154	Ras	MONDO|Ensembl=ENSMODG00000003841|UniProtKB=F7EBP6	Uncharacterized protein	ISS			PTHR24073:SF335	RAS-RELATED PROTEIN RAB-11B
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00010	B cell activation	P00371	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PANTR|Ensembl=ENSPTRG00000019155|UniProtKB=H2R110	Uncharacterized protein	ISS			PTHR13140:SF381	UNCONVENTIONAL MYOSIN-IG
P00059	p53 pathway	P01486	Akt	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	TAS	14526383	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00053	T cell activation	P01300	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00200	Dsh	MACMU|Ensembl=ENSMMUG00000010542|UniProtKB=F7D0L2	Segment polarity protein dishevelled homolog DVL-2	ISS	11212302	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P00010	B cell activation	P00373	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00056	VEGF signaling pathway	P01423	p38MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00047	PDGF signaling pathway	P01161	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01275	P38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	TAS	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00060	Ubiquitin proteasome pathway	P01490	E3	HUMAN|HGNC=16807|UniProtKB=Q9HCE7	E3 ubiquitin-protein ligase SMURF1	ISS	11252892	PubMed	PTHR11254:SF293	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000025240|UniProtKB=F7A7I3	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	11840290	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00048	PI3 kinase pathway	P01188	Gbetagamma	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P02772	Pyruvate metabolism	P03141	Citrate Synthetase	BOVIN|Ensembl=ENSBTAG00000004371|UniProtKB=Q29RK1	Citrate synthase, mitochondrial	ISS	2337600	PubMed	PTHR11739:SF8	CITRATE SYNTHASE, MITOCHONDRIAL
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	IDA	12736250	PubMed	PTHR10202:SF18	PRESENILIN-1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00029	Huntington disease	P00786	ARF	TAKRU|Ensembl=ENSTRUG00000007465|UniProtKB=H2T1E8	Uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF291	ADP-RIBOSYLATION FACTOR 1
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	IC	10514528	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00056	VEGF signaling pathway	P01407	Erk	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DANRE|ZFIN=ZDB-GENE-030131-6503|UniProtKB=Q7ZUC5	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF297	PROTEIN KINASE C DELTA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IC	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01330	IKK	PANTR|Ensembl=ENSPTRG00000020202|UniProtKB=H2QW34	Uncharacterized protein	ISS	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CHICK|Ensembl=ENSGALG00000008339|UniProtKB=E1BQS9	Uncharacterized protein	ISS			PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-010705-1|UniProtKB=Q90Z40	Guanine nucleotide-binding protein subunit gamma	IC	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00005	Angiogenesis	P00220	c-Jun	XENTR|Xenbase=XB-GENE-482228|UniProtKB=F6RYL1	Uncharacterized protein	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00053	T cell activation	P01336	Jnk	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04393	Ras Pathway	P04560	AP1	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00046	Oxidative stress response	P01137	MNK1/2	MOUSE|MGI=MGI=894279|UniProtKB=Q8CDB0	MAP kinase-interacting serine/threonine-protein kinase 2	ISS	11463832	PubMed	PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00018	EGF receptor signaling pathway	P00564	Rac	DICDI|dictyBase=DDB_G0268622|UniProtKB=P34145	Rho-related protein rac1B	IGI	12932731	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04572	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	DANRE|ZFIN=ZDB-GENE-010406-5|UniProtKB=A2BGQ1	Uncharacterized protein	ISS			PTHR22778:SF37	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01219	SAPK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00034	Integrin signalling pathway	P00951	Jnk	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IDA	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	MOUSE|MGI=MGI=1920431|UniProtKB=Q8K120	Nuclear factor of activated T-cells, cytoplasmic 4	ISS	12015605	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=1757|UniProtKB=Q13634	Cadherin-18	IDA	8120095	PubMed	PTHR24027:SF106	CADHERIN-18
P00052	TGF-beta signaling pathway	P01284	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00057	Wnt signaling pathway	P01444	Wnt	PANTR|Ensembl=ENSPTRG00000004519|UniProtKB=H2Q569	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05913	Enkephalin release	P05972	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	94280860	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00011	Blood coagulation	P00446	FVIIIa	CANLF|Gene=F8|UniProtKB=O18806	Coagulation factor VIII	ISS	2645493	gi	PTHR45309:SF1	COAGULATION FACTOR VIII
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00034	Integrin signalling pathway	P00924	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	RAT|RGD=1591873|UniProtKB=D3ZWC5	Protein Bmp8b	ISS	9759503	PubMed	PTHR11848:SF132	BONE MORPHOGENETIC PROTEIN 8B
P00059	p53 pathway	P04630	PP2A	DANRE|ZFIN=ZDB-GENE-040426-2487|UniProtKB=Q803G3	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P06587	Nicotine pharmacodynamics pathway	P06601	FLNA	MACMU|Ensembl=ENSMMUG00000013668|UniProtKB=F7GCM2	Uncharacterized protein	ISS	9722563	PubMed	PTHR43998:SF6	FILAMIN-A
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	CANLF|Ensembl=ENSCAFG00000001315|UniProtKB=E2R9S7	Uncharacterized protein	ISS	1768802	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P04398	p53 pathway feedback loops 2	P04669	ATM	XENTR|Xenbase=XB-GENE-1012722|UniProtKB=F7DU67	Uncharacterized protein	ISS	10196661	PubMed	PTHR11139:SF69	SERINE/THREONINE-PROTEIN KINASE ATR
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000002016|UniProtKB=F1P3G1	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	MACMU|Ensembl=ENSMMUG00000001661|UniProtKB=F7GR69	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	RAT|RGD=621544|UniProtKB=P12391	Neuronal acetylcholine receptor subunit beta-3	IC	85270494	PubMed	PTHR18945:SF75	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-3
P04385	Histamine H1 receptor mediated signaling pathway	P04485	H1	BOVIN|Gene=HRH1|UniProtKB=P30546	Histamine H1 receptor	ISS	11841575	PubMed	PTHR43914:SF2	HISTAMINE H1 RECEPTOR
P04393	Ras Pathway	P04567	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	CHICK|Ensembl=ENSGALG00000015434|UniProtKB=F1NU20	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00006	Apoptosis signaling pathway	P00292	IkappaB	CHICK|Gene=NFKBIA|UniProtKB=Q91974	NF-kappa-B inhibitor alpha	ISS	14665694	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00048	PI3 kinase pathway	P01177	P110ACT	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	IC	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	SCHPO|PomBase=SPBC32H8.07|UniProtKB=Q10282	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00011	Blood coagulation	P00418	Fibrin monomer	XENTR|Xenbase=XB-GENE-483216|UniProtKB=B0JZ09	Fgb protein	ISS	95369693	PubMed	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00057	Wnt signaling pathway	P01465	Ggamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P02781	Threonine biosynthesis	P03190	Threonine synthase	RAT|RGD=1564213|UniProtKB=E9PTK4	Protein Thnsl1	ISS			PTHR43515:SF1	THREONINE SYNTHASE-LIKE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00010	B cell activation	P00381	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00056	VEGF signaling pathway	P01417	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00046	Oxidative stress response	P01134	cPLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	TAS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	SCLS1|EnsemblGenome=SS1G_05445|UniProtKB=A7EJF2	Mitogen-activated protein kinase	ISS			PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	TAS	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00887	IRS 1-4	BOVIN|Ensembl=ENSBTAG00000021308|UniProtKB=F1MYE0	Uncharacterized protein	ISS	5031805	gi	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00056	VEGF signaling pathway	P01425	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	HUMAN|HGNC=10433|UniProtKB=O75676	Ribosomal protein S6 kinase alpha-4	ISS	6755374	gi	PTHR24351:SF41	RIBOSOMAL PROTEIN S6 KINASE ALPHA-4
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	BOVIN|Ensembl=ENSBTAG00000037794|UniProtKB=E1BP87	Uncharacterized protein	IEP	89264452	PubMed	PTHR13140:SF681	MYOSIN-4
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00203	Erk	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00009	Axon guidance mediated by netrin	P00364	cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00048	PI3 kinase pathway	P01188	Gbetagamma	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04393	Ras Pathway	P04553	PAK	MOUSE|MGI=MGI=1339975|UniProtKB=O88643	Serine/threonine-protein kinase PAK 1	IDA	14580336	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00234	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	15210125	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00052	TGF-beta signaling pathway	P01275	P38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00036	Interleukin signaling pathway	P00990	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00243	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00005	Angiogenesis	P00187	beta catenin	CANLF|Ensembl=ENSCAFG00000005204|UniProtKB=B6V8E6	Catenin beta-1	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000011757|UniProtKB=Q9XT97	Presenilin-1	TAS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	PANTR|Ensembl=ENSPTRG00000004222|UniProtKB=H2Q4N4	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF165	COLLAGENASE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	CAEEL|WormBase=WBGene00001679|UniProtKB=P17343	Guanine nucleotide-binding protein subunit beta-1	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	PANTR|Ensembl=ENSPTRG00000001144|UniProtKB=H2PZR0	Uncharacterized protein	ISS	15927770	PubMed	PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P00021	FGF signaling pathway	P00629	PP2A	ORNAN|Ensembl=ENSOANG00000005732|UniProtKB=F6X0X1	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	BRAFL|Gene=BRAFLDRAFT_219190|UniProtKB=C3Z434	Serine/threonine-protein phosphatase (Fragment)	ISS	10433257	PubMed	PTHR11668:SF402	SERINE/THREONINE-PROTEIN PHOSPHATASE
P02747	Histidine biosynthesis	P02985	Histidinol dehydrogenase	RHOBA|EnsemblGenome=RB1584|UniProtKB=Q7UX39	Histidinol dehydrogenase	ISS			PTHR21256:SF2	HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN
P00049	Parkinson disease	P01211	ERK	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	IDA	12787066	PubMed	PTHR24055:SF330	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT1G10210|UniProtKB=Q39021	Mitogen-activated protein kinase 1	ISS	9836510	gi	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00056	VEGF signaling pathway	P01405	VRAP	MACMU|Ensembl=ENSMMUG00000010917|UniProtKB=F7GLS8	Uncharacterized protein	ISS	Q9NP31	SPACC	PTHR14388:SF9	SH2 DOMAIN-CONTAINING PROTEIN 2A
P00005	Angiogenesis	P00211	GSK3beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02788	Xanthine and guanine salvage pathway	P03247	Xanthine phosphoribosyl transferase	STRCO|Gene=CAB42758|UniProtKB=Q9X8I5	Putative hypoxanthine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00034	Integrin signalling pathway	P00944	Actin	MONDO|Ensembl=ENSMODG00000023940|UniProtKB=F6RFW8	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00036	Interleukin signaling pathway	P00977	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P06664	Gonadotropin-releasing hormone receptor pathway	P06740	BMPR-IA/IB/II	MOUSE|MGI=MGI=1338938|UniProtKB=P36895	Bone morphogenetic protein receptor type-1A	RCA	9395284	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=3765|UniProtKB=P30938	Somatostatin receptor type 5	IDA	12562507	PubMed	PTHR24229:SF20	SOMATOSTATIN RECEPTOR TYPE 5
P00018	EGF receptor signaling pathway	G01511	SPRY	DROME|FlyBase=FBgn0014388|UniProtKB=O44783	Protein sprouty	IGI	98117253	PubMed	PTHR12365:SF7	PROTEIN SPROUTY
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	IDA	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P02751	Lysine biosynthesis	P03008	Dihydrodipicolinate synthase	METJA|EnsemblGenome=MJ_0244|UniProtKB=Q57695	4-hydroxy-tetrahydrodipicolinate synthase	ISS			PTHR12128:SF15	4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01352	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	IC	9199552	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00566	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	XENTR|Xenbase=XB-GENE-957124|UniProtKB=F7BDN8	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00056	VEGF signaling pathway	P01419	Ets	MACMU|Ensembl=ENSMMUG00000020706|UniProtKB=F6PU72	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00034	Integrin signalling pathway	P00924	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00524	LIMK	BOVIN|Ensembl=ENSBTAG00000044083|UniProtKB=E1BC64	Uncharacterized protein	ISS			PTHR44124:SF1	LIM DOMAIN KINASE 1
P00005	Angiogenesis	P00254	GTPase	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00047	PDGF signaling pathway	P01153	GSK3	RAT|RGD=620351|UniProtKB=P18265	Glycogen synthase kinase-3 alpha	ISS	14698990	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00053	T cell activation	P01318	PKC-theta	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	USTMA|Gene=UMAG_11232|UniProtKB=A0A0D1DMT3	Chromosome 22, whole genome shotgun sequence	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00054	Toll receptor signaling pathway	P01361	TBK1	CANLF|Ensembl=ENSCAFG00000000356|UniProtKB=E2R4G3	Uncharacterized protein	ISS			PTHR22969:SF14	SERINE/THREONINE-PROTEIN KINASE TBK1
P00056	VEGF signaling pathway	P01407	Erk	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00034	Integrin signalling pathway	P00935	ILK	PANTR|Ensembl=ENSPTRG00000003298|UniProtKB=H2Q325	Integrin-linked kinase	ISS			PTHR44344:SF1	INTEGRIN-LINKED PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04398	p53 pathway feedback loops 2	P04665	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-040718-134|UniProtKB=Q6DH55	Guanine nucleotide binding protein (G protein), beta polypeptide 3, like	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00256	PLC-gamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00029	Huntington disease	P00796	Kainate receptor	DANRE|Ensembl=ENSDARG00000070511|UniProtKB=E7F5R2	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF282	GLUTAMATE RECEPTOR-RELATED
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	ARATH|TAIR=AT5G15570|UniProtKB=Q9LF25	Bromodomain transcription factor	ISS	604905	OMIM	PTHR12321:SF53	BROMODOMAIN TRANSCRIPTION FACTOR
P00010	B cell activation	P00397	IKK	HUMAN|HGNC=1974|UniProtKB=O15111	Inhibitor of nuclear factor kappa-B kinase subunit alpha	IGI	12235208	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P04393	Ras Pathway	P04541	p90RSK	MACMU|Ensembl=ENSMMUG00000022111|UniProtKB=F7H7W3	Ribosomal protein S6 kinase	ISS	7688567	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00006	Apoptosis signaling pathway	P00260	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00058	mRNA splicing	P01474	U5	CHICK|Ensembl=ENSGALG00000000615|UniProtKB=F1NUK8	Uncharacterized protein	ISS	9774689	PubMed	PTHR44006:SF1	U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MOUSE|MGI=MGI=1338027|UniProtKB=Q9Z1W4	Growth/differentiation factor 11	TAS	9759503	PubMed	PTHR11848:SF166	GROWTH/DIFFERENTIATION FACTOR 11
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	CHICK|Ensembl=ENSGALG00000011442|UniProtKB=Q90999	TGF-beta receptor type-2	TAS	9395284	PubMed	PTHR23255:SF55	TGF-BETA RECEPTOR TYPE-2
P00049	Parkinson disease	P01208	Hsp70	TRIVA|Gene=TVAG_137250|UniProtKB=A2FNS7	Cytosolic heat shock protein 70, putative	IDA	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P05916	Opioid prodynorphin pathway	P06000	vasopressin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00053	T cell activation	P01319	PAK	ORNAN|Ensembl=ENSOANG00000002406|UniProtKB=F7BAS2	Uncharacterized protein	ISS	11259591	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	BOVIN|Ensembl=ENSBTAG00000011579|UniProtKB=F1N5C5	Muscarinic acetylcholine receptor	ISS	10069496	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00021	FGF signaling pathway	P00632	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00046	Oxidative stress response	P01129	JNK1/2	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02913	Thymidylate synthase	ARATH|TAIR=AT2G21550|UniProtKB=Q9SIK4	Bifunctional dihydrofolate reductase-thymidylate synthase	ISS			PTHR11548:SF7	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE
P00023	General transcription regulation	P00658	TBP-associated factors	DROME|FlyBase=FBgn0010417|UniProtKB=P49847	Transcription initiation factor TFIID subunit 6	ISS			PTHR10221:SF12	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347740|UniProtKB=E9FXV8	Cytoplasmatic actin	ISS	11889126	PubMed	PTHR11937:SF277	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00005	Angiogenesis	P00238	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TRIVA|Gene=TVAG_090470|UniProtKB=A2FA04	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00006	Apoptosis signaling pathway	P00282	IGFR2	BOVIN|Gene=IGF2R|UniProtKB=P08169	Cation-independent mannose-6-phosphate receptor	IDA	13642251	gi	PTHR15071:SF17	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
P00036	Interleukin signaling pathway	P00965	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04431	5HT transporter	HUMAN|HGNC=11050|UniProtKB=P31645	Sodium-dependent serotonin transporter	ISS	14653308	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04380	Cortocotropin releasing factor receptor signaling pathway	P04455	beta-endorphin	BOVIN|Ensembl=ENSBTAG00000007897|UniProtKB=P01190	Pro-opiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00029	Huntington disease	P00775	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00019	Endothelin signaling pathway	P00586	Gq	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00057	Wnt signaling pathway	P01435	SWI/SNF	CANLF|Ensembl=ENSCAFG00000014105|UniProtKB=E2RMD3	Uncharacterized protein	ISS	11532957	PubMed	PTHR10019:SF5	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY B MEMBER 1
P00021	FGF signaling pathway	P00642	MEK1-2	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05730	Endogenous cannabinoid signaling	P05746	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014555|UniProtKB=F7GT55	Syntaxin-1A isoform 1	ISS	1321498	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	SCHPO|PomBase=SPBC12D12.04c|UniProtKB=P36583	Protein kinase C-like 2	TAS	8491190	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00057	Wnt signaling pathway	P01452	NFAT	MACMU|Ensembl=ENSMMUG00000021843|UniProtKB=F6RNI3	Uncharacterized protein	ISS	12787506	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	IC	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00006	Apoptosis signaling pathway	P00317	Fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P02762	Pentose phosphate pathway	P03081	Transaldolase	MACMU|Ensembl=ENSMMUG00000007510|UniProtKB=F7CBD5	Transaldolase	ISS	8300619	PubMed	PTHR10683:SF18	TRANSALDOLASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00047	PDGF signaling pathway	P01167	Ets	MOUSE|MGI=MGI=1350926|UniProtKB=Q8R4Z4	ETS translocation variant 3	ISS	15298723	PubMed	PTHR11849:SF30	ETS TRANSLOCATION VARIANT 3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	SCHMA|EnsemblGenome=Smp_046600|UniProtKB=G4VLW2	Putative actin-1	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	RAT|RGD=621440|UniProtKB=Q63511	G protein-activated inward rectifier potassium channel 3	IDA			PTHR11767:SF17	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MOUSE|MGI=MGI=1354734|UniProtKB=Q9DC04	Regulator of G-protein signaling 3	IDA	8756726	PubMed	PTHR10845:SF4	REGULATOR OF G-PROTEIN SIGNALING 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00018	EGF receptor signaling pathway	P00555	MKK4,7	PANTR|Ensembl=ENSPTRG00000008783|UniProtKB=H2QCA7	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00016	Cytoskeletal regulation by Rho GTPase	P00521	Profilin	TRYB2|Gene=Tb11.01.5350|UniProtKB=Q382F9	Profilin	ISS			PTHR11604:SF0	PROFILIN
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	BOVIN|Ensembl=ENSBTAG00000003532|UniProtKB=F1MWR6	Uncharacterized protein	ISS	9783586	PubMed	PTHR10814:SF21	TRANSDUCIN-LIKE ENHANCER PROTEIN 4
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00645	Rac	DICPU|Gene=DICPUDRAFT_92985|UniProtKB=F1A084	Putative uncharacterized protein rac1A	ISS	12932731	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00010	B cell activation	P00384	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	MONDO|Ensembl=ENSMODG00000024440|UniProtKB=F7DJJ2	Muscarinic acetylcholine receptor	ISS	12181435	PubMed	PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CAEEL|WormBase=WBGene00000063|UniProtKB=P0DM41	Actin-1	ISS	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00168	E-cadherin intracellular fragment	PANTR|Ensembl=ENSPTRG00000008270|UniProtKB=H2QBE5	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF319	CADHERIN-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05918	p38 MAPK pathway	P06021	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04542	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	CANLF|Ensembl=ENSCAFG00000013148|UniProtKB=Q5R1P3	Glutamate receptor ionotropic, NMDA 2B	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P05731	GABA-B receptor II signaling	P05755	Gbeta	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P06664	Gonadotropin-releasing hormone receptor pathway	P06850	PKCs(3)	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	RCA	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02728	Arginine biosynthesis	P02846	Ornithine carbamoyl transferase	HUMAN|HGNC=8512|UniProtKB=P00480	Ornithine carbamoyltransferase, mitochondrial	ISS			PTHR11405:SF1	ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL
P00039	Metabotropic glutamate receptor group III pathway	P01043	AC	PANTR|Ensembl=ENSPTRG00000001638|UniProtKB=H2Q0J3	Adenylate cyclase type 10	ISS	10915626	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MACMU|Ensembl=ENSMMUG00000018568|UniProtKB=F6YLW2	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00019	Endothelin signaling pathway	P00587	Raf-1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IGI	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00007	Axon guidance mediated by semaphorins	P00341	Rho	HUMAN|HGNC=667|UniProtKB=P61586	Transforming protein RhoA	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P02726	Aminobutyrate degradation	P02825	4-aminobutyrate aminotransferase	MOUSE|MGI=MGI=2443582|UniProtKB=P61922	4-aminobutyrate aminotransferase, mitochondrial	ISS	8133261	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00010	B cell activation	P00373	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IGI	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00045	Notch signaling pathway	P01114	Ntm	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00029	Huntington disease	P00778	NMDA receptor	CANLF|Ensembl=ENSCAFG00000013148|UniProtKB=Q5R1P3	Glutamate receptor ionotropic, NMDA 2B	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00034	Integrin signalling pathway	P00944	Actin	BOVIN|Ensembl=ENSBTAG00000005714|UniProtKB=Q3ZC07	Actin, alpha cardiac muscle 1	ISS	3487386	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	9298898	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00628	JNK1-3	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00193	SOS-1	DROME|FlyBase=FBgn0001965|UniProtKB=P26675	Protein son of sevenless	ISS			PTHR23113:SF99	PROTEIN SON OF SEVENLESS
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	SCHMA|EnsemblGenome=Smp_183710|UniProtKB=G4VLW1	Putative actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00004	Alzheimer disease-presenilin pathway	P00118	E-cadherin	HUMAN|HGNC=1748|UniProtKB=P12830	Cadherin-1	IDA	11953314	PubMed	PTHR24027:SF319	CADHERIN-1
P00015	Circadian clock system	P00502	Casein kinase I	ORNAN|Ensembl=ENSOANG00000010562|UniProtKB=F6TBG4	Uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00057	Wnt signaling pathway	P01438	PP2A	CHICK|Ensembl=ENSGALG00000010273|UniProtKB=P48463	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	IDA	2461222	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00591	PLCbeta	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02757	O-antigen biosynthesis	P03045	dTDP-glucose 4,6-dehydratase	MOUSE|MGI=MGI=1923605|UniProtKB=Q8VDR7	dTDP-D-glucose 4,6-dehydratase	ISS			PTHR43000:SF7	DTDP-D-GLUCOSE 4,6-DEHYDRATASE
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00023	General transcription regulation	P00658	TBP-associated factors	ANOGA|Gene=AgaP_AGAP010493|UniProtKB=Q7Q8X9	AGAP010493-PA (Fragment)	ISS			PTHR12228:SF0	TAF7 RNA POLYMERASE II, TATA BOX BINDING PROTEIN  TBP -ASSOCIATED FACTOR
P00019	Endothelin signaling pathway	P00584	Gs	CAEEL|WormBase=WBGene00001745|UniProtKB=Q7KPV0	G protein, Subunit Alpha	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01081	Ca2+ channel	HUMAN|HGNC=1399|UniProtKB=P54289	Voltage-dependent calcium channel subunit alpha-2/delta-1	ISS	92228762	PubMed	PTHR10166:SF6	VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-1
P00049	Parkinson disease	P01235	Fyn kinase	RAT|RGD=2641|UniProtKB=Q62844	Tyrosine-protein kinase Fyn	IDA	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00006	Apoptosis signaling pathway	P00318	PKCs	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00009	Axon guidance mediated by netrin	P00366	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00020	FAS signaling pathway	P00593	Caspase9	PANTR|Ensembl=ENSPTRG00000000200|UniProtKB=H2PY35	Caspase	ISS	9390557	PubMed	PTHR10454:SF157	CASPASE-9
P00047	PDGF signaling pathway	P01154	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P06664	Gonadotropin-releasing hormone receptor pathway	P06850	PKCs(3)	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02743	Formyltetrahydroformate biosynthesis	P02954	Thymidylate synthase	MACMU|Ensembl=ENSMMUG00000004046|UniProtKB=F6ZR77	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	RAT|RGD=2917|UniProtKB=P15127	Insulin receptor	ISS	6754360	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00045	Notch signaling pathway	P01101	Su(H)	CHICK|Ensembl=ENSGALG00000014365|UniProtKB=F1NIJ8	Uncharacterized protein	ISS	9043084	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	IC	8836152	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00036	Interleukin signaling pathway	P00973	PKB	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	ISS	6466184	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05915	Opioid proenkephalin pathway	P05994	G-protein	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	MACMU|Ensembl=ENSMMUG00000017654|UniProtKB=F6UI32	Beta-arrestin-2 isoform 1	ISS	9388255	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00170	Aph-1	MACMU|Ensembl=ENSMMUG00000017856|UniProtKB=F7DK04	Uncharacterized protein	ISS	12110170	PubMed	PTHR12889:SF1	GAMMA-SECRETASE SUBUNIT APH-1B
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01438	PP2A	DANRE|ZFIN=ZDB-GENE-030904-6|UniProtKB=Q7ZUQ2	Ppp2r5e1 protein	ISS	10092233	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00034	Integrin signalling pathway	P00914	Filamin	RAT|RGD=1311915|UniProtKB=A0A0G2JXT8	Protein Flnb	ISS	9722563	PubMed	PTHR43998:SF3	FILAMIN-B
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00049	Parkinson disease	P01215	Syntaxin	HUMAN|HGNC=11430|UniProtKB=Q86Y82	Syntaxin-12	IPI	14570579	PubMed	PTHR19957:SF88	SYNTAXIN-12
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	THEMA|EnsemblGenome=TM_1873|UniProtKB=Q9X2I6	Ornithine decarboxylase	ISS			PTHR11482:SF6	ORNITHINE DECARBOXYLASE 1-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P02772	Pyruvate metabolism	P03138	Malate Dehydrogenase	METJA|EnsemblGenome=MJ_1425|UniProtKB=Q58820	L-sulfolactate dehydrogenase	ISS	20309698	PubMed	PTHR11091:SF0	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00170	Aph-1	CANLF|Ensembl=ENSCAFG00000011777|UniProtKB=E2R5H5	Anterior pharynx defective 1 homolog A	ISS	12110170	PubMed	PTHR12889:SF3	GAMMA-SECRETASE SUBUNIT APH-1A
P00017	DNA replication	P00534	PCNA	BOVIN|Ensembl=ENSBTAG00000006065|UniProtKB=Q3ZBW4	Proliferating cell nuclear antigen	ISS	12893285	PubMed	PTHR11352:SF0	PROLIFERATING CELL NUCLEAR ANTIGEN
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	MONDO|Ensembl=ENSMODG00000002696|UniProtKB=F7CY56	Uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF335	CALMODULIN, STRIATED MUSCLE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00057	Wnt signaling pathway	P01433	SIAH-1	DROME|FlyBase=FBgn0003410|UniProtKB=P21461	E3 ubiquitin-protein ligase sina	ISS	11389839	PubMed	PTHR10315:SF70	E3 UBIQUITIN-PROTEIN LIGASE SINA-RELATED
P02759	Pyridoxal-5-phosphate biosynthesis	P03061	Pyridoxine-5-phosphate oxidase	CANLF|Ensembl=ENSCAFG00000016814|UniProtKB=E2QTE2	Uncharacterized protein	ISS	9601034	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00023	General transcription regulation	P00670	TBP	HUMAN|HGNC=11589|UniProtKB=P62380	TATA box-binding protein-like protein 1	IGI	600075	OMIM	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00012	Cadherin signaling pathway	P00467	alpha-catenin	PANTR|Ensembl=ENSPTRG00000017291|UniProtKB=H2QRK9	Catenin (Cadherin-associated protein), alpha 1, 102kDa	ISS	1768802	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	CHICK|Ensembl=ENSGALG00000007039|UniProtKB=F1NG99	Tyrosine-protein kinase receptor	ISS	249616	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02738	De novo purine biosynthesis	P02904	Guanylate kinase	ARATH|TAIR=AT2G41880|UniProtKB=P93757	Guanylate kinase 1	ISS			PTHR23117:SF13	GUANYLATE KINASE
P00018	EGF receptor signaling pathway	G01511	SPRY	RAT|RGD=1305324|UniProtKB=D3ZJA3	Protein Spry4	ISS	10330503	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00020	FAS signaling pathway	P00612	Fas	MACMU|Gene=FAS|UniProtKB=Q9BDP2	Tumor necrosis factor receptor superfamily member 6	TAS	14585074	PubMed	PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P00029	Huntington disease	P00777	CBP	ARATH|TAIR=AT1G67220|UniProtKB=Q9FYH1	Histone acetyltransferase HAC2	IDA	10769018	PubMed	PTHR13808:SF6	HISTONE ACETYLTRANSFERASE HAC2
P00003	Alzheimer disease-amyloid secretase pathway	P00092	TACE	BOVIN|Ensembl=ENSBTAG00000001141|UniProtKB=G3MZB3	Uncharacterized protein	ISS	9774383	PubMed	PTHR11905:SF171	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17
P00057	Wnt signaling pathway	P01440	Cadherin	CHICK|Ensembl=ENSGALG00000012917|UniProtKB=Q90762	Cadherin-6	IDA	8120095	PubMed	PTHR24027:SF322	CADHERIN-6
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	PANTR|Ensembl=ENSPTRG00000019310|UniProtKB=H2QUS4	C-C motif chemokine	ISS	5174671	gi	PTHR12015:SF73	C-C MOTIF CHEMOKINE 26
P02736	Coenzyme A biosynthesis	P02885	Pantothenate kinase	ANOGA|EnsemblGenome=AGAP011715|UniProtKB=Q7PVC2	AGAP011715-PA (Fragment)	ISS			PTHR12280:SF30	FUMBLE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CANLF|Ensembl=ENSCAFG00000002617|UniProtKB=E2QUL1	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00018	EGF receptor signaling pathway	P00543	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00524	LIMK	MOUSE|MGI=MGI=104572|UniProtKB=P53668	LIM domain kinase 1	ISS			PTHR44124:SF1	LIM DOMAIN KINASE 1
P00047	PDGF signaling pathway	P01162	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00256	PLC-gamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=3234|UniProtKB=P33535	Mu-type opioid receptor	IDA	11259487	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00036	Interleukin signaling pathway	P00965	ERK	CHICK|Ensembl=ENSGALG00000004690|UniProtKB=Q5F3W3	Mitogen-activated protein kinase 6	ISS	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00717	Phosphorylase b	RAT|RGD=3460|UniProtKB=P53534	Glycogen phosphorylase, brain form (Fragment)	IDA	4318782	PubMed	PTHR11468:SF1	GLYCOGEN PHOSPHORYLASE, BRAIN FORM
P04393	Ras Pathway	P04553	PAK	RAT|RGD=61953|UniProtKB=Q64303	Serine/threonine-protein kinase PAK 2	IDA	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00029	Huntington disease	P00775	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00024	Glycolysis	P00672	Phosphofructokinase-1	MACMU|Ensembl=ENSMMUG00000002045|UniProtKB=F7H6E6	ATP-dependent 6-phosphofructokinase	RCA			PTHR13697:SF13	ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE, MUSCLE TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	IC	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00059	p53 pathway	P04634	Cdc2	RAT|RGD=2319|UniProtKB=P39951	Cyclin-dependent kinase 1	ISS			PTHR24056:SF334	CYCLIN-DEPENDENT KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000024992|UniProtKB=F6TUR3	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DICDI|dictyBase=DDB_G0274383|UniProtKB=Q8MLZ3	cGMP-dependent 3',5'-cGMP phosphodiesterase A	IC	91298951	PubMed	PTHR45452:SF1	SUBFAMILY NOT NAMED
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00053	T cell activation	P01312	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01043	AC	PANTR|Ensembl=ENSPTRG00000001638|UniProtKB=H2Q0J3	Adenylate cyclase type 10	ISS	11744988	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P00004	Alzheimer disease-presenilin pathway	P00110	Ire-1 N-terminal fragment	HUMAN|HGNC=3449|UniProtKB=O75460	Serine/threonine-protein kinase/endoribonuclease IRE1	IDA	10619423	PubMed	PTHR13954:SF17	SERINE/THREONINE-PROTEIN KINASE/ENDORIBONUCLEASE IRE1
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00011	Blood coagulation	P00408	Plasminogen	MOUSE|MGI=MGI=97620|UniProtKB=P20918	Plasminogen	ISS	11928811	PubMed	PTHR24261:SF5	PLASMINOGEN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	IDA	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00015	Circadian clock system	P00502	Casein kinase I	HUMAN|HGNC=2452|UniProtKB=P48730	Casein kinase I isoform delta	ISS	10617630	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00018	EGF receptor signaling pathway	P00549	EGF	MACMU|Ensembl=ENSMMUG00000010043|UniProtKB=F6TFM0	Uncharacterized protein	RCA			PTHR44717:SF1	PRO-EPIDERMAL GROWTH FACTOR
P00048	PI3 kinase pathway	P01192	p110	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	TAKRU|Ensembl=ENSTRUG00000015213|UniProtKB=H2UPJ1	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF356	SUBFAMILY NOT NAMED
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	ECOLI|EcoGene=EG10407|UniProtKB=P04805	Glutamate--tRNA ligase	ISS			PTHR43311:SF2	GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED
P00012	Cadherin signaling pathway	P00474	Wnt	PANTR|Ensembl=ENSPTRG00000000313|UniProtKB=H2PY99	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00005	Angiogenesis	P00189	Fzd	MONDO|Ensembl=ENSMODG00000011428|UniProtKB=F6RKF7	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF34	FRIZZLED-2
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00021	FGF signaling pathway	P00642	MEK1-2	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00005	Angiogenesis	P00219	PKC	CANLF|Ensembl=ENSCAFG00000006119|UniProtKB=E2R428	Serine/threonine-protein kinase	ISS	12676944	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=106598|UniProtKB=P21271	Unconventional myosin-Vb	ISS			PTHR13140:SF356	UNCONVENTIONAL MYOSIN-VB
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	PANTR|Ensembl=ENSPTRG00000018684|UniProtKB=C7G3M7	Glutamate receptor, metabotropic 1	ISS			PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00052	TGF-beta signaling pathway	P01289	I-Smads	HUMAN|HGNC=6773|UniProtKB=O15105	Mothers against decapentaplegic homolog 7	IGI	9335505	PubMed	PTHR13703:SF27	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 7
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00057	Wnt signaling pathway	P01444	Wnt	CAEEL|WormBase=WBGene00003029|UniProtKB=Q27886	Abnormal cell lineage protein 44	ISS	8717036	PubMed	PTHR12027:SF102	PROTEIN WNT-4
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	BOVIN|Ensembl=ENSBTAG00000007047|UniProtKB=A3KMX5	FZD10 protein	ISS	8717036	PubMed	PTHR11309:SF86	FRIZZLED-10
P04393	Ras Pathway	P04572	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	DROME|FlyBase=FBgn0014006|UniProtKB=Q9VDS9	Apoptotic signal-regulating kinase 1, isoform C	ISS			PTHR11584:SF369	APOPTOTIC SIGNAL-REGULATING KINASE 1, ISOFORM C
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12676940	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00029	Huntington disease	P00793	Arfaptin-2	RAT|RGD=1303204|UniProtKB=Q6AY65	Arfaptin-2	ISS	11854752	PubMed	PTHR12141:SF3	ARFAPTIN-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MACMU|Ensembl=ENSMMUG00000018805|UniProtKB=F6ZI45	Uncharacterized protein	ISS	12356903	PubMed	PTHR11514:SF3	N-MYC PROTO-ONCOGENE PROTEIN
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	DROME|FlyBase=FBgn0033010|UniProtKB=Q8SX87	Atf6, isoform C	ISS			PTHR22952:SF367	ATF6, ISOFORM C
P00006	Apoptosis signaling pathway	P00268	GCK	HUMAN|HGNC=6864|UniProtKB=Q12851	Mitogen-activated protein kinase kinase kinase kinase 2	ISS			PTHR24361:SF392	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 2
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05731	GABA-B receptor II signaling	P05755	Gbeta	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	IC	9199552	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00021	FGF signaling pathway	P00627	ERK1-2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	RAT|RGD=3425|UniProtKB=P97887	Presenilin-1	IDA	12736250	PubMed	PTHR10202:SF18	PRESENILIN-1
P00047	PDGF signaling pathway	P01175	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	95096035	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00005	Angiogenesis	P00238	Ras	CAEEL|WormBase=WBGene00002335|UniProtKB=P22981	Ras protein let-60	ISS			PTHR24070:SF385	GTPASE HRAS
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	HUMAN|HGNC=7174|UniProtKB=P09237	Matrilysin	TAS	12834808	PubMed	PTHR10201:SF143	MATRILYSIN
P00005	Angiogenesis	P00199	JNKK1	CHICK|Ensembl=ENSGALG00000001001|UniProtKB=F1P3T1	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00029	Huntington disease	P00805	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00990	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00626	Spry	PANTR|Ensembl=ENSPTRG00000017360|UniProtKB=H2QRP3	Uncharacterized protein	ISS	22024232	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MACMU|Ensembl=ENSMMUG00000003296|UniProtKB=F7FG01	Uncharacterized protein	ISS	9865691	PubMed	PTHR17045:SF6	CBP/P300-INTERACTING TRANSACTIVATOR 1
P00004	Alzheimer disease-presenilin pathway	P00126	Fe65	HUMAN|HGNC=20708|UniProtKB=O95704	Amyloid beta A4 precursor protein-binding family B member 3	IDA			PTHR14058:SF10	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 3
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00018	EGF receptor signaling pathway	P00557	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	G04702	p53	MOUSE|MGI=MGI=1336991|UniProtKB=Q9JJP2	Tumor protein p73	TAS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00049	Parkinson disease	P01238	14-3-3	CANLF|Ensembl=ENSCAFG00000003386|UniProtKB=F6Y478	Uncharacterized protein	ISS	7603573	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P00007	Axon guidance mediated by semaphorins	P00330	CRAM	ORNAN|Ensembl=ENSOANG00000000514|UniProtKB=F7CVF2	Uncharacterized protein	ISS	10851247	PubMed	PTHR11647:SF58	DIHYDROPYRIMIDINASE-RELATED PROTEIN 5
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00763	Hip-12	MACMU|Ensembl=ENSMMUG00000008786|UniProtKB=F7F6A6	Intraflagellar transport protein 57 homolog	ISS			PTHR16011:SF0	INTRAFLAGELLAR TRANSPORT PROTEIN 57 HOMOLOG
P00034	Integrin signalling pathway	P00910	Grb2	MOUSE|MGI=MGI=1918770|UniProtKB=Q9CX99	GRB2-related adapter protein	ISS	8051109	PubMed	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00045	Notch signaling pathway	P01104	Serrate	BOVIN|Ensembl=ENSBTAG00000012817|UniProtKB=E1BDN7	Delta-like protein	ISS	7697721	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P02753	Methionine biosynthesis	P03026	O-Succinyl homoserine lyase	PYRAE|EnsemblGenome=PAE2420|UniProtKB=Q8ZV75	Cystathionine gamma-synthase	ISS			PTHR11808:SF15	CYSTATHIONINE GAMMA-LYASE
P00029	Huntington disease	P00786	ARF	GIAIC|EnsemblGenome=GL50803_7789|UniProtKB=A8BSW7	ADP-ribosylation factor	IPI	12932731	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	15528206	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00375	Calmodulin	ORYSJ|EnsemblGenome=OS01G0267900|UniProtKB=Q0JNS6	Calmodulin-1	ISS	3885394	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00019	Endothelin signaling pathway	P00566	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00780	Microtubule	STRPU|EnsemblGenome=SPU_007424|UniProtKB=W4XVG8	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF155	TUBULIN BETA-2 CHAIN
P00003	Alzheimer disease-amyloid secretase pathway	P00095	Nicastrin	MOUSE|MGI=MGI=1891700|UniProtKB=P57716	Nicastrin	IDA	16096062	PubMed	PTHR21092:SF0	NICASTRIN
P00034	Integrin signalling pathway	P00931	Integrin beta	DROME|FlyBase=FBgn0004657|UniProtKB=P11584	Integrin beta-PS	IDA	3487386	PubMed	PTHR10082:SF41	INTEGRIN BETA-PS
P00045	Notch signaling pathway	P01113	Pen-2	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	12885769	PubMed	PTHR10202:SF13	PRESENILIN-2
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00947	Laminin	HUMAN|HGNC=6482|UniProtKB=P24043	Laminin subunit alpha-2	IPI	2538453	PubMed	PTHR10574:SF291	LAMININ SUBUNIT ALPHA-2
P00053	T cell activation	P01322	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	PANTR|Ensembl=ENSPTRG00000024086|UniProtKB=H2R1M3	Uncharacterized protein	ISS	11943840	PubMed	PTHR24248:SF3	BETA-3 ADRENERGIC RECEPTOR
P00053	T cell activation	P01313	CD28	HUMAN|HGNC=1653|UniProtKB=P10747	T-cell-specific surface glycoprotein CD28	ISS	7534617	PubMed	PTHR11494:SF7	T-CELL-SPECIFIC SURFACE GLYCOPROTEIN CD28
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000028172|UniProtKB=H2R4H9	Uncharacterized protein	ISS			PTHR45535:SF1	MELATONIN-RELATED RECEPTOR
P00053	T cell activation	P01332	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IDA	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00756	Recoverin	MOUSE|MGI=MGI=97883|UniProtKB=P34057	Recoverin	ISS	7608179	PubMed	PTHR23055:SF20	RECOVERIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CANLF|Ensembl=ENSCAFG00000003333|UniProtKB=F1PWT6	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00046	Oxidative stress response	P01137	MNK1/2	RAT|RGD=1559603|UniProtKB=Q4G050	MAP kinase-interacting serine/threonine-protein kinase 1	ISS	11575158	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	HUMAN|HGNC=144|UniProtKB=P63261	Actin, cytoplasmic 2	IDA	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P02738	De novo purine biosynthesis	P02907	dADP kinase	ORNAN|Ensembl=ENSOANG00000011750|UniProtKB=F6TWB9	Nucleoside diphosphate kinase	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P00021	FGF signaling pathway	P00642	MEK1-2	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	MOUSE|MGI=MGI=103296|UniProtKB=P97305	Nuclear factor of activated T-cells, cytoplasmic 3	ISS	12015605	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00047	PDGF signaling pathway	P01175	Shc	MOUSE|MGI=MGI=98296|UniProtKB=P98083	SHC-transforming protein 1	ISS	10982827	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00006	Apoptosis signaling pathway	P00317	Fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=1760|UniProtKB=Q9HBT6	Cadherin-20	IDA	8120095	PubMed	PTHR24027:SF84	CADHERIN-20
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00005	Angiogenesis	P00189	Fzd	DANRE|ZFIN=ZDB-GENE-990415-224|UniProtKB=F1QBI2	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF34	FRIZZLED-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CANLF|Gene=MYH1|UniProtKB=Q076A6	Myosin-1	ISS	10938134	PubMed	PTHR13140:SF484	MYOSIN-1
P02757	O-antigen biosynthesis	P03045	dTDP-glucose 4,6-dehydratase	BACSU|EnsemblGenome=BSU37830|UniProtKB=P39630	dTDP-glucose 4,6-dehydratase	ISS			PTHR43000:SF7	DTDP-D-GLUCOSE 4,6-DEHYDRATASE
P00009	Axon guidance mediated by netrin	P00366	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT1G07880|UniProtKB=Q9LQQ9	Mitogen-activated protein kinase 13	ISS	10514528	PubMed	PTHR24055:SF185	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IDA	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00019	Endothelin signaling pathway	P00566	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02738	De novo purine biosynthesis	P02909	GDP reductase	SULSO|EnsemblGenome=SSO0929|UniProtKB=Q97ZH9	Ribonucleotide reductase (Nrd)	ISS			PTHR43371:SF1	SUBFAMILY NOT NAMED
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05731	GABA-B receptor II signaling	P05752	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CHICK|Ensembl=ENSGALG00000015434|UniProtKB=F1NU20	Uncharacterized protein	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00029	Huntington disease	P00805	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01067	AChE	PANTR|Ensembl=ENSPTRG00000015593|UniProtKB=H2QNP1	Carboxylic ester hydrolase	ISS	86008285	PubMed	PTHR43918:SF5	CHOLINESTERASE
P00045	Notch signaling pathway	P01112	CoR	MOUSE|MGI=MGI=1337080|UniProtKB=Q9WU42	Nuclear receptor corepressor 2	TAS	10441327	PubMed	PTHR13992:SF21	NUCLEAR RECEPTOR COREPRESSOR 2
P00029	Huntington disease	P00780	Microtubule	MOUSE|MGI=MGI=107813|UniProtKB=Q9ERD7	Tubulin beta-3 chain	IDA	12932731	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	DANRE|ZFIN=ZDB-GENE-020503-1|UniProtKB=Q1LWJ4	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF498	TYROSINE-PROTEIN KINASE RECEPTOR
P04398	p53 pathway feedback loops 2	P04651	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	ORNAN|Ensembl=ENSOANG00000003049|UniProtKB=F7B0P2	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	HUMAN|HGNC=5287|UniProtKB=P28222	5-hydroxytryptamine receptor 1B	IDA			PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P00018	EGF receptor signaling pathway	P00554	Shc	BOVIN|Ensembl=ENSBTAG00000019838|UniProtKB=Q0IIE2	SHC-transforming protein 1	ISS	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	IDA	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00059	p53 pathway	P04609	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	9516481	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	CHICK|Ensembl=ENSGALG00000012617|UniProtKB=Q06900	Receptor protein serine/threonine kinase	IDA			PTHR23255:SF61	TGF-BETA RECEPTOR TYPE-1
P00005	Angiogenesis	P00210	eNOS	CANLF|Gene=NOS3|UniProtKB=Q9TUX8	Nitric oxide synthase, endothelial	ISS	9837777	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00059	p53 pathway	P04609	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00024	Glycolysis	P00672	Phosphofructokinase-1	PANTR|Ensembl=ENSPTRG00000004874|UniProtKB=H2RBN9	ATP-dependent 6-phosphofructokinase	RCA			PTHR13697:SF13	ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE, MUSCLE TYPE
P05913	Enkephalin release	P05974	G-Protein (i)	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TAKRU|Ensembl=ENSTRUG00000007989|UniProtKB=P68140	Actin, alpha skeletal muscle A	IC	14684598	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00036	Interleukin signaling pathway	P00975	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	227170	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00019	Endothelin signaling pathway	P00568	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IGI	15572354	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_115566|UniProtKB=C3XYC8	Putative uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04393	Ras Pathway	P04547	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P02738	De novo purine biosynthesis	P02908	Phosphoribosylamine glycine ligase	HALSA|EnsemblGenome=VNG_1305G|UniProtKB=Q9HQ67	Phosphoribosylamine--glycine ligase	ISS			PTHR43472:SF1	PHOSPHORIBOSYLAMINE--GLYCINE LIGASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	PANTR|Ensembl=ENSPTRG00000017551|UniProtKB=P60021	Histamine H2 receptor	ISS	8817552	PubMed	PTHR43893:SF5	HISTAMINE H2 RECEPTOR
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DANRE|ZFIN=ZDB-GENE-030131-172|UniProtKB=Q6IQR3	Actin, alpha, cardiac muscle 1a	IDA	11889139	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00001	Adrenaline and noradrenaline biosynthesis	P00063	DBH	HUMAN|HGNC=2689|UniProtKB=P09172	Dopamine beta-hydroxylase	ISS	90219125	PubMed	PTHR10157:SF29	DOPAMINE BETA-HYDROXYLASE
P05916	Opioid prodynorphin pathway	P05999	provasopressin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	HUMAN|HGNC=2520|UniProtKB=Q9NRF8	CTP synthase 2	ISS			PTHR11550:SF2	CTP SYNTHASE 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02747	Histidine biosynthesis	P02992	Imidazol glycerol phosphate synthase	ECOLI|EcoGene=EG10450|UniProtKB=P60595	Imidazole glycerol phosphate synthase subunit HisH	ISS			PTHR42701:SF1	IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISH
P00034	Integrin signalling pathway	P00931	Integrin beta	MOUSE|MGI=MGI=96610|UniProtKB=P09055	Integrin beta-1	IDA	3487386	PubMed	PTHR10082:SF28	INTEGRIN BETA-1
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00046	Oxidative stress response	P01132	c-jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04398	p53 pathway feedback loops 2	P04665	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-486685|UniProtKB=F6VT32	Protein kinase C	ISS	11880265	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=7573|UniProtKB=P11055	Myosin-3	IC	89264452	PubMed	PTHR13140:SF427	MYOSIN-3
P05915	Opioid proenkephalin pathway	P05987	peptide F	DANRE|ZFIN=ZDB-GENE-030729-3|UniProtKB=F1QTD1	Uncharacterized protein (Fragment)	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P05917	Opioid proopiomelanocortin pathway	P06011	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	ISS	8557110	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	ANOGA|EnsemblGenome=AGAP004476|UniProtKB=Q7QA16	AGAP004476-PA	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00057	Wnt signaling pathway	P01443	Phospholipase C	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MOUSE|MGI=MGI=95770|UniProtKB=P30678	Guanine nucleotide-binding protein subunit alpha-15	IC	8838318	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P06959	CCKR signaling map	P07212	p85	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	RCA	16297869	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00005	Angiogenesis	P00235	c-Fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=1306297|UniProtKB=D4ADD1	Protein Pcdh20	ISS	8120095	PubMed	PTHR43912:SF7	PROTOCADHERIN-20
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MONDO|Ensembl=ENSMODG00000016595|UniProtKB=F6ZDB2	Uncharacterized protein	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	TAS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	IC	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IGI	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00025	Hedgehog signaling pathway	P00692	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000020224|UniProtKB=H2Q9G3	Mitogen-activated protein kinase 6	ISS	8444355	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00555	MKK4,7	CANLF|Ensembl=ENSCAFG00000017851|UniProtKB=F1PBB6	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00018	EGF receptor signaling pathway	P00546	GAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	20908895	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	RAT|RGD=621663|UniProtKB=P19139	Casein kinase II subunit alpha	IDA	10806215	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	MOUSE|MGI=MGI=101863|UniProtKB=P05063	Fructose-bisphosphate aldolase C	ISS	7768978	PubMed	PTHR11627:SF3	FRUCTOSE-BISPHOSPHATE ALDOLASE C
P00018	EGF receptor signaling pathway	P00557	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000002775|UniProtKB=H2RB55	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00056	VEGF signaling pathway	P01425	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000017435|UniProtKB=H2QRU2	Uncharacterized protein	ISS	8120095	PubMed	PTHR24026:SF37	PROTOCADHERIN FAT 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MOUSE|MGI=MGI=1339713|UniProtKB=Q5SX39	Myosin-4	IEP	89264452	PubMed	PTHR13140:SF657	MYOSIN-4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02920	dCTP deaminase	CAEEL|WormBase=WBGene00010436|UniProtKB=Q95QD6	Uncharacterized protein	ISS			PTHR11079:SF92	TRNA-SPECIFIC ADENOSINE DEAMINASE 2
P00029	Huntington disease	P00778	NMDA receptor	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	IDA	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	SCHPO|PomBase=SPBC16G5.01|UniProtKB=P50524	26S proteasome regulatory subunit rpn12	ISS			PTHR12387:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8
P00021	FGF signaling pathway	P00645	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	IPI	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=7569|UniProtKB=P35749	Myosin-11	IC	89264452	PubMed	PTHR13140:SF335	MYOSIN-11
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	MOUSE|MGI=MGI=96603|UniProtKB=Q00651	Integrin alpha-4	IDA	11035110	PubMed	PTHR23220:SF78	INTEGRIN ALPHA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00848	Grb	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8617307	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P06959	CCKR signaling map	P07119	MAPK3	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	RCA	16816139	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	RAT|RGD=621332|UniProtKB=Q99MF4	Interleukin-11 receptor subunit alpha	IEP	11570967	PubMed	PTHR23036:SF29	INTERLEUKIN-11 RECEPTOR SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00038	JAK/STAT signaling pathway	P01027	STAT	TAKRU|Ensembl=ENSTRUG00000011114|UniProtKB=H2TTP1	Signal transducer and activator of transcription	ISS			PTHR11801:SF19	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 4
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00049	Parkinson disease	P01242	Casein kinase I	ARATH|TAIR=AT1G04440|UniProtKB=Q5XF24	At1g04440	IDA	10617630	PubMed	PTHR11909:SF178	CASEIN KINASE 1-LIKE PROTEIN 8
P00036	Interleukin signaling pathway	P00994	FKHRL1	BOVIN|Ensembl=ENSBTAG00000011234|UniProtKB=F1N4K5	Uncharacterized protein	ISS	15031210	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00010	B cell activation	P00381	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IDA	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	HUMAN|HGNC=7576|UniProtKB=P13533	Myosin-6	ISS	10938134	PubMed	PTHR13140:SF721	MYOSIN-6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DROME|FlyBase=FBgn0000042|UniProtKB=P10987	Actin-5C	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00058	mRNA splicing	P01477	U2AF35	RAT|RGD=1561824|UniProtKB=Q5RK33	Protein Zrsr1	ISS			PTHR12620:SF2	U2 SMALL NUCLEAR RIBONUCLEOPROTEIN AUXILIARY FACTOR 35 KDA SUBUNIT-RELATED PROTEIN 1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00030	Hypoxia response via HIF activation	P00823	PI3K	SCHPO|PomBase=SPAC458.05|UniProtKB=P50520	Phosphatidylinositol 3-kinase vps34	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CAEBR|Gene=CBG02161|UniProtKB=A8WS32	Protein CBG02161	ISS	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000013047|UniProtKB=E1BLE8	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00018	EGF receptor signaling pathway	P00539	14-3-3	XENTR|Xenbase=XB-GENE-996375|UniProtKB=F7DY42	Uncharacterized protein	ISS	98119747	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=7608|UniProtKB=B2RTY4	Unconventional myosin-IXa	IC			PTHR13140:SF9	UNCONVENTIONAL MYOSIN-IXA
P00021	FGF signaling pathway	P00643	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00010	B cell activation	P00397	IKK	MACMU|Ensembl=ENSMMUG00000008351|UniProtKB=F7HRV5	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00564	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12176041	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00057	Wnt signaling pathway	P01433	SIAH-1	MOUSE|MGI=MGI=108064|UniProtKB=P61092	E3 ubiquitin-protein ligase SIAH1A	IDA	11389839	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00019	Endothelin signaling pathway	P00589	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	IGI	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MOUSE|MGI=MGI=104589|UniProtKB=P63268	Actin, gamma-enteric smooth muscle	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	STRPU|EnsemblGenome=SPU_005033|UniProtKB=W4XNQ0	Uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF263	SUBFAMILY NOT NAMED
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	BOVIN|Ensembl=ENSBTAG00000047202|UniProtKB=G3N3K3	Uncharacterized protein	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00019	Endothelin signaling pathway	P00586	Gq	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IDA	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00589	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04392	P53 pathway feedback loops 1	P04539	p53	DANRE|ZFIN=ZDB-GENE-990415-270|UniProtKB=P79734	Cellular tumor antigen p53	TAS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	1718748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	DANRE|ZFIN=ZDB-GENE-990415-224|UniProtKB=F1QBI2	Uncharacterized protein	TAS	8717036	PubMed	PTHR11309:SF34	FRIZZLED-2
P00059	p53 pathway	P04623	CBP	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	IDA	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MONDO|Ensembl=ENSMODG00000004799|UniProtKB=F6VM87	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00057	Wnt signaling pathway	P01465	Ggamma	MONDO|Ensembl=ENSMODG00000000771|UniProtKB=F6SSS3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	MACMU|Ensembl=ENSMMUG00000011442|UniProtKB=F7B9T3	Ras-related protein Rap-1b	ISS	10476970	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DANRE|ZFIN=ZDB-GENE-000322-1|UniProtKB=Q9I8V1	Actin, alpha 1, skeletal muscle	ISS	11889126	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00029	Huntington disease	P00807	Actin	STRPU|EnsemblGenome=SPU_012282|UniProtKB=W4Y969	Uncharacterized protein	IDA	11889126	PubMed	PTHR11937:SF369	ACTIN-42A
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IC	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00021	FGF signaling pathway	P00640	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00476	Yes	ORNAN|Ensembl=ENSOANG00000005501|UniProtKB=F6X6I5	Tyrosine-protein kinase	ISS			PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MONDO|Ensembl=ENSMODG00000004360|UniProtKB=F7FAW0	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF335	MYOSIN-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01297	MEKK	PANTR|Ensembl=ENSPTRG00000016891|UniProtKB=H2R5K3	Uncharacterized protein	RCA	12168099	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00052	TGF-beta signaling pathway	P01275	P38	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	TAS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DICDI|dictyBase=DDB_G0289489|UniProtKB=P07828	Actin-18	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00005	Angiogenesis	P00256	PLC-gamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00034	Integrin signalling pathway	P00922	Collagen	DROME|FlyBase=FBgn0000299|UniProtKB=P08120	Collagen alpha-1(IV) chain	IDA	10778855	PubMed	PTHR24023:SF674	COLLAGEN ALPHA-1 IV  CHAIN-RELATED
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00630	RKIP	CAEEL|WormBase=WBGene00013477|UniProtKB=Q9XW37	Uncharacterized protein	ISS			PTHR11362:SF44	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00757	beta-arrestin	PANTR|Ensembl=ENSPTRG00000013052|UniProtKB=H2QJM8	Uncharacterized protein	ISS	10206946	PubMed	PTHR11792:SF15	S-ARRESTIN
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00053	T cell activation	P01332	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	IDA	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	MACMU|Ensembl=ENSMMUG00000000135|UniProtKB=F7H624	Excitatory amino acid transporter 3	ISS	96032356	PubMed	PTHR11958:SF69	EXCITATORY AMINO ACID TRANSPORTER 3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	HUMAN|HGNC=145|UniProtKB=P63267	Actin, gamma-enteric smooth muscle	IDA	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	TAS	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00018	EGF receptor signaling pathway	P00539	14-3-3	ORNAN|Ensembl=ENSOANG00000007305|UniProtKB=F6XW91	Uncharacterized protein	ISS	12865427	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00572	MEK	CAEBR|Gene=CBG04190|UniProtKB=A8WWD7	Protein CBR-MEK-2	ISS	12024031	PubMed	PTHR24361:SF629	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1
P00034	Integrin signalling pathway	P00938	Cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00047	PDGF signaling pathway	P01142	p90RSK	MACMU|Ensembl=ENSMMUG00000002134|UniProtKB=F6UNV6	Ribosomal protein S6 kinase	ISS	10480933	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	CHICK|Ensembl=ENSGALG00000002447|UniProtKB=E1C7M7	Uncharacterized protein	ISS	9362521	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P02741	Flavin biosynthesis	P02939	Lumazine synthase	THEMA|EnsemblGenome=TM_1825|UniProtKB=Q9X2E5	6,7-dimethyl-8-ribityllumazine synthase	ISS			PTHR21058:SF0	6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00005	Angiogenesis	P00223	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	BOVIN|Gene=CACNB1|UniProtKB=Q9MZL7	Voltage-dependent L-type calcium channel subunit beta-1	IC	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IGI	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00029	Huntington disease	P00778	NMDA receptor	MOUSE|MGI=MGI=2150393|UniProtKB=Q91ZU9	Glutamate receptor ionotropic, NMDA 3B	IDA	14698601	PubMed	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00056	VEGF signaling pathway	P01414	PLC-gamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00053	T cell activation	P01337	B7	CANLF|Ensembl=ENSCAFG00000010997|UniProtKB=Q9TQX1	B7-1 protein	IDA	1650475	PubMed	PTHR25466:SF4	T-LYMPHOCYTE ACTIVATION ANTIGEN CD80
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00049	Parkinson disease	P01211	ERK	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	IDA	10514528	PubMed	PTHR24055:SF330	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00983	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	RAT|RGD=69424|UniProtKB=Q99P84	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	12176394	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00012	Cadherin signaling pathway	P00470	F-actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g210933|UniProtKB=A7SEA7	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P02727	Androgen/estrogene/progesterone biosynthesis	P02829	Cholesterol acyltransferase	HUMAN|HGNC=11178|UniProtKB=O75908	Sterol O-acyltransferase 2	ISS	9756918	PubMed	PTHR10408:SF10	STEROL O-ACYLTRANSFERASE 2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-486685|UniProtKB=F6VT32	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IC	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9441|UniProtKB=P51817	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04393	Ras Pathway	P04558	p38	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	IDA	20451058	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00036	Interleukin signaling pathway	P00967	c-fos	RAT|RGD=2626|UniProtKB=P12841	Proto-oncogene c-Fos	TAS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P05915	Opioid proenkephalin pathway	P05994	G-protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00238	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00095	Nicastrin	ARATH|TAIR=AT3G52640|UniProtKB=Q8GUM5	Nicastrin	IDA	16096062	PubMed	PTHR21092:SF0	NICASTRIN
P00046	Oxidative stress response	P01131	MKP5	MOUSE|MGI=MGI=1923821|UniProtKB=Q9DAR2	Protein Styxl1	ISS			PTHR10159:SF336	SERINE/THREONINE/TYROSINE-INTERACTING-LIKE PROTEIN 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	9514948	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00055	Transcription regulation by bZIP transcription factor	P01392	TFIIH complex	DICDI|dictyBase=DDB_G0275517|UniProtKB=Q86IB5	General transcription factor IIH subunit 3	ISS			PTHR12831:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3
P00005	Angiogenesis	P00204	PLD	BOVIN|Gene=PLD2|UniProtKB=Q0V8L6	Phospholipase D2	ISS	15030398	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00916	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00053	T cell activation	P01332	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	20855874	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00182	p38MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00036	Interleukin signaling pathway	P00968	Ikk	RAT|RGD=621375|UniProtKB=Q9QY78	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	PYRAE|EnsemblGenome=PAE1645|UniProtKB=Q8ZWS3	Transcription initiation factor IIB	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P00036	Interleukin signaling pathway	P00967	c-fos	RAT|RGD=2626|UniProtKB=P12841	Proto-oncogene c-Fos	TAS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00056	VEGF signaling pathway	P01423	p38MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1346876|UniProtKB=O35099	Mitogen-activated protein kinase kinase kinase 5	ISS			PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4401|UniProtKB=O14775	Guanine nucleotide-binding protein subunit beta-5	IC	11313908	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00046	Oxidative stress response	P01135	p38	DROME|FlyBase=FBgn0015765|UniProtKB=O62618	Mitogen-activated protein kinase 14A	TAS	10851062	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	RAT|RGD=2156|UniProtKB=P29066	Beta-arrestin-1	IDA	11742073	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	PANTR|Gene=CHRM2|UniProtKB=Q9N2A7	Muscarinic acetylcholine receptor M2 (Fragment)	ISS	10069496	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12805548	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00056	VEGF signaling pathway	P01415	MAPKAPK2/3	BOVIN|Ensembl=ENSBTAG00000038107|UniProtKB=F1MCX5	Uncharacterized protein	ISS	9628873	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00047	PDGF signaling pathway	P01174	Rho	CAEEL|WormBase=WBGene00015303|UniProtKB=O01443	Rho GTPase Activating protein	ISS			PTHR12635:SF7	RHO GTPASE ACTIVATING PROTEIN AT 102A, ISOFORM D
P02723	Adenine and hypoxanthine salvage pathway	P02813	Inosine phosphorylase	THEMA|EnsemblGenome=TM_1737|UniProtKB=Q9X259	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00053	T cell activation	P01322	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IGI	14526383	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05916	Opioid prodynorphin pathway	P06002	G-protein	ANOGA|EnsemblGenome=AGAP005913|UniProtKB=Q7Q6D2	AGAP005913-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00021	FGF signaling pathway	P00632	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	PANTR|Ensembl=ENSPTRG00000019739|UniProtKB=H2QVG0	Uncharacterized protein	ISS	608972	OMIM	PTHR22952:SF96	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 2
P02746	Heme biosynthesis	P02974	Uroporphyrinogen-III synthase	SCHPO|PomBase=SPAC31G5.08|UniProtKB=P87214	Uroporphyrinogen-III synthase	ISS			PTHR12390:SF0	UROPORPHYRINOGEN-III SYNTHASE
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	IDA	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P06959	CCKR signaling map	G06996	MMP7	HUMAN|HGNC=7174|UniProtKB=P09237	Matrilysin	RCA	20637111	PubMed	PTHR10201:SF143	MATRILYSIN
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P06587	Nicotine pharmacodynamics pathway	P06611	CLIC6	PANTR|Ensembl=ENSPTRG00000013882|UniProtKB=H2QZZ0	Chloride intracellular channel protein	ISS	14499480	PubMed	PTHR45476:SF1	CHLORIDE INTRACELLULAR CHANNEL PROTEIN 6
P00059	p53 pathway	P04609	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00006	Apoptosis signaling pathway	P00310	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	IDA	1171954	gi	PTHR10048:SF14	PI-3 KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CHICK|Ensembl=ENSGALG00000008339|UniProtKB=E1BQS9	Uncharacterized protein	ISS			PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	PANTR|Ensembl=ENSPTRG00000018684|UniProtKB=C7G3M7	Glutamate receptor, metabotropic 1	ISS	12351712	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2743|UniProtKB=P31421	Metabotropic glutamate receptor 2	IDA	12488551	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00048	PI3 kinase pathway	P01199	Galpha	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	IC	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05730	Endogenous cannabinoid signaling	P05746	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00047	PDGF signaling pathway	P01143	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01455	Smad4	CHICK|Ensembl=ENSGALG00000006309|UniProtKB=Q56I99	Mothers against decapentaplegic homolog 5	ISS	9395284	PubMed	PTHR13703:SF36	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5
P00019	Endothelin signaling pathway	P00589	Akt	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	IGI	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	IDA	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00022	General transcription by RNA polymerase I	P00649	TAF-IC	CANLF|Ensembl=ENSCAFG00000001622|UniProtKB=E2RN76	Uncharacterized protein	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00029	Huntington disease	P00786	ARF	MOUSE|MGI=MGI=99435|UniProtKB=P62331	ADP-ribosylation factor 6	ISS	12932731	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P02777	Succinate to proprionate conversion	P03163	Methylmalonyl-CoA decarboxylase	DEIRA|EnsemblGenome=DR_1316|UniProtKB=Q9RUR6	Methylmalonyl-CoA carboxyltransferase	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	BOVIN|Ensembl=ENSBTAG00000009245|UniProtKB=Q0P594	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CHICK|Ensembl=ENSGALG00000017238|UniProtKB=F1NWG3	Uncharacterized protein	IDA	12488551	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00053	T cell activation	P01306	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00004	Alzheimer disease-presenilin pathway	P00148	Erb-B4 N-terminal fragment	MOUSE|MGI=MGI=104771|UniProtKB=Q61527	Receptor tyrosine-protein kinase erbB-4	ISS	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00021	FGF signaling pathway	P00636	FGFR1-4	MOUSE|MGI=MGI=95522|UniProtKB=P16092	Fibroblast growth factor receptor 1	IPI	9989949	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P00012	Cadherin signaling pathway	P00465	TCF/LEF	MOUSE|MGI=MGI=1202876|UniProtKB=Q9Z1J1	Transcription factor 7-like 1	ISS	11266476	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00030	Hypoxia response via HIF activation	P00819	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00049	Parkinson disease	P01239	Cul-1	HUMAN|HGNC=2551|UniProtKB=Q13616	Cullin-1	IDA	12628165	PubMed	PTHR11932:SF81	CULLIN-1
P00059	p53 pathway	P04612	HDAC1	MONDO|Ensembl=ENSMODG00000017455|UniProtKB=F6Z5R3	Uncharacterized protein (Fragment)	ISS	12665570	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	CANLF|Ensembl=ENSCAFG00000003995|UniProtKB=E2RC09	Tyrosine-protein kinase	ISS	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	IXOSC|EnsemblGenome=ISCW009711|UniProtKB=B7Q3T6	THO complex subunit, putative	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P05912	Dopamine receptor mediated signaling pathway	P05968	CLIC6	MACMU|Ensembl=ENSMMUG00000004605|UniProtKB=F6Q8V4	Chloride intracellular channel protein	ISS	14499480	PubMed	PTHR45476:SF1	CHLORIDE INTRACELLULAR CHANNEL PROTEIN 6
P00022	General transcription by RNA polymerase I	P00650	TAF-IB	MACMU|Ensembl=ENSMMUG00000012470|UniProtKB=F7G0B2	Uncharacterized protein	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IC	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00053	T cell activation	P01324	rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00029	Huntington disease	P00775	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	10540223	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	PANTR|Ensembl=ENSPTRG00000020674|UniProtKB=H2QWV4	Uncharacterized protein	ISS			PTHR23291:SF16	PROTEIN LIFEGUARD 1
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	HUMAN|HGNC=9508|UniProtKB=P49768	Presenilin-1	IDA	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00705	Gsalpha	CHICK|Ensembl=ENSGALG00000013785|UniProtKB=E1BS74	Uncharacterized protein	ISS	6309844	PubMed	PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	BOVIN|Ensembl=ENSBTAG00000005800|UniProtKB=F1N3G8	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00004	Alzheimer disease-presenilin pathway	P00141	Membrane metalloprotease	MOUSE|MGI=MGI=1341867|UniProtKB=Q9R0S2	Matrix metalloproteinase-24	RCA			PTHR10201:SF138	MATRIX METALLOPROTEINASE-24
P02738	De novo purine biosynthesis	P02907	dADP kinase	SYNY3|EnsemblGenome=BAA18596|UniProtKB=P74494	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	GIAIC|EnsemblGenome=GL50803_101291|UniProtKB=A8BEI6	Beta tubulin	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00005	Angiogenesis	P00223	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00019	Endothelin signaling pathway	P00581	Guanylate cyclase	MACMU|Ensembl=ENSMMUG00000013419|UniProtKB=F6Z2P2	Uncharacterized protein	RCA			PTHR11920:SF276	GUANYLATE CYCLASE SOLUBLE SUBUNIT ALPHA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00005	Angiogenesis	P00212	EphR	MOUSE|MGI=MGI=104770|UniProtKB=P54754	Ephrin type-B receptor 3	IGI	9990854	PubMed	PTHR24416:SF506	EPHRIN TYPE-B RECEPTOR 3
P05913	Enkephalin release	P05974	G-Protein (i)	DROME|FlyBase=FBgn0001105|UniProtKB=P26308	Guanine nucleotide-binding protein subunit beta-1	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00005	Angiogenesis	P00200	Dsh	MONDO|Ensembl=ENSMODG00000006553|UniProtKB=F7BUW7	Uncharacterized protein	ISS	11212302	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	METAC|EnsemblGenome=MA_1665|UniProtKB=Q8TQ86	Ribonucleotide reductase	ISS			PTHR43371:SF1	SUBFAMILY NOT NAMED
P00059	p53 pathway	G01579	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00021	FGF signaling pathway	P00636	FGFR1-4	BOVIN|Ensembl=ENSBTAG00000014064|UniProtKB=F1MNW2	Fibroblast growth factor receptor	ISS	14507786	PubMed	PTHR24416:SF130	FIBROBLAST GROWTH FACTOR RECEPTOR 2
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	PANTR|Ensembl=ENSPTRG00000001477|UniProtKB=H2Q0A5	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P04398	p53 pathway feedback loops 2	P04653	cdk2	CANLF|Ensembl=ENSCAFG00000000082|UniProtKB=E2QW70	Uncharacterized protein	ISS	15660127	PubMed	PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P00005	Angiogenesis	P00256	PLC-gamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00036	Interleukin signaling pathway	P00981	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	CANLF|Ensembl=ENSCAFG00000018144|UniProtKB=F1PNI3	Uncharacterized protein	ISS	3391172	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00049	Parkinson disease	P01211	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01151	PKB	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	22081553	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04556	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000005917|UniProtKB=F6QM53	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	DROME|FlyBase=FBgn0010051|UniProtKB=P29993	Inositol 1,4,5-trisphosphate receptor	IDA	11007872	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00798	Clathrin	RAT|RGD=621353|UniProtKB=P08082	Clathrin light chain B	ISS	9388255	PubMed	PTHR10639:SF2	CLATHRIN LIGHT CHAIN B
P00025	Hedgehog signaling pathway	P00699	Su(fu)	HUMAN|HGNC=16466|UniProtKB=Q9UMX1	Suppressor of fused homolog	IDA	12068298	PubMed	PTHR10928:SF2	SUPPRESSOR OF FUSED HOMOLOG
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MONDO|Ensembl=ENSMODG00000015573|UniProtKB=F7AIP6	Uncharacterized protein (Fragment)	ISS	9118222	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00019	Endothelin signaling pathway	P00585	ECE1-3	HUMAN|HGNC=3147|UniProtKB=O95672	Endothelin-converting enzyme-like 1	ISS	9931490	PubMed	PTHR11733:SF195	ENDOTHELIN-CONVERTING ENZYME-LIKE 1
P00029	Huntington disease	P00805	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00235	c-Fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00056	VEGF signaling pathway	P01414	PLC-gamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	DROME|FlyBase=FBgn0024179|UniProtKB=M9PE88	Receptor protein serine/threonine kinase	ISS	11856529	PubMed	PTHR23255:SF52	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00865	Shc	MOUSE|MGI=MGI=98296|UniProtKB=P98083	SHC-transforming protein 1	ISS	7798194	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00060	Ubiquitin proteasome pathway	P01494	19S proteasome	XENTR|Xenbase=XB-GENE-5855370|UniProtKB=Q66JJ6	OTTXETP00000006803	ISS			PTHR23073:SF8	26S PROTEASE REGULATORY SUBUNIT 6B
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00005	Angiogenesis	P00253	Axin	DANRE|ZFIN=ZDB-GENE-000403-1|UniProtKB=P57094	Axin-1	ISS	9554852	PubMed	PTHR10845:SF11	AXIN-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IC	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000001962|UniProtKB=F6V2H6	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00005	Angiogenesis	P00193	SOS-1	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00053	T cell activation	P01332	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IGI	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00024	Glycolysis	P00679	Aldolase	RAT|RGD=2089|UniProtKB=P05065	Fructose-bisphosphate aldolase A	ISS	4812352	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	RCA	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00048	PI3 kinase pathway	P01179	PKB	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	TAS	22084520	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	MACMU|Ensembl=ENSMMUG00000009607|UniProtKB=F7A586	5-hydroxytryptamine receptor 2C	ISS	11859080	PubMed	PTHR24247:SF32	5-HYDROXYTRYPTAMINE RECEPTOR 2C
P00021	FGF signaling pathway	P00643	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	IDA	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00049	Parkinson disease	P01238	14-3-3	DANRE|ZFIN=ZDB-GENE-011115-1|UniProtKB=Q6PC29	14-3-3 protein gamma-1	ISS	91108808	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00037	Ionotropic glutamate receptor pathway	P01006	NR2C	RAT|RGD=2740|UniProtKB=Q62645	Glutamate receptor ionotropic, NMDA 2D	ISS			PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00059	p53 pathway	P04633	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01095	beta	HUMAN|HGNC=1962|UniProtKB=P17787	Neuronal acetylcholine receptor subunit beta-2	ISS	15155845	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P00048	PI3 kinase pathway	P01199	Galpha	PANTR|Ensembl=ENSPTRG00000001056|UniProtKB=H2PZL0	Uncharacterized protein	ISS			PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P00059	p53 pathway	G04702	p53	CANLF|Gene=TP53|UniProtKB=Q29537	Cellular tumor antigen p53	TAS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00030	Hypoxia response via HIF activation	P00819	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	IPI	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MACMU|Ensembl=ENSMMUG00000016376|UniProtKB=F7G2W1	Uncharacterized protein	ISS	11730323	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	CHLTR|EnsemblGenome=CT_844|UniProtKB=O84851	tRNA-specific adenosine deaminase	ISS			PTHR11079:SF149	TRNA-SPECIFIC ADENOSINE DEAMINASE
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	YEAST|SGD=S000001081|UniProtKB=P38694	Putative aldehyde dehydrogenase-like protein YHR039C	IC			PTHR11699:SF25	ALDEHYDE DEHYDROGENASE-LIKE PROTEIN YHR039C-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	EMENI|EnsemblGenome=CADANIAG00006296|UniProtKB=Q5ASG1	Putative synaptobrevin homologue SNC1/2 (Eurofung)	ISS			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00010	B cell activation	P00371	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01067	AChE	MOUSE|MGI=MGI=894278|UniProtKB=Q03311	Cholinesterase	IC			PTHR43918:SF5	CHOLINESTERASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=1351339|UniProtKB=Q14BI2	Metabotropic glutamate receptor 2	ISS	9407094	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00005	Angiogenesis	P00254	GTPase	PANTR|Ensembl=ENSPTRG00000001112|UniProtKB=H2PZP2	Ras homolog gene family, member C	ISS	14871999	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	PANTR|Ensembl=ENSPTRG00000010617|UniProtKB=H2QFL8	Notch 3	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00049	Parkinson disease	P01235	Fyn kinase	TAKRU|Ensembl=ENSTRUG00000014739|UniProtKB=H2UL58	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00041	Metabotropic glutamate receptor group I pathway	P01062	mGluR1	MOUSE|MGI=MGI=1351338|UniProtKB=P97772	Metabotropic glutamate receptor 1	ISS	9407094	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04393	Ras Pathway	P04561	SRF	DANRE|ZFIN=ZDB-GENE-990714-29|UniProtKB=A8HAM3	Uncharacterized protein	ISS	10330504	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CRYNJ|EnsemblGenome=CNA04650|UniProtKB=Q5KP06	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00624	14-3-3	IXOSC|EnsemblGenome=ISCW011376|UniProtKB=B7Q5I4	Multifunctional chaperone, putative	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01471	alpha-catenin	CHICK|Ensembl=ENSGALG00000002447|UniProtKB=E1C7M7	Uncharacterized protein	ISS	1904011	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00054	Toll receptor signaling pathway	P01381	Ubc13	HUMAN|HGNC=12492|UniProtKB=P61088	Ubiquitin-conjugating enzyme E2 N	ISS			PTHR43902:SF5	UBIQUITIN-CONJUGATING ENZYME E2 N
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00005	Angiogenesis	P00249	PAK	MOUSE|MGI=MGI=1339975|UniProtKB=O88643	Serine/threonine-protein kinase PAK 1	ISS	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00018	EGF receptor signaling pathway	P00557	PI3K	CAEEL|WormBase=WBGene00004879|UniProtKB=O01510	Serine/threonine-protein kinase smg-1	ISS			PTHR11139:SF71	SERINE/THREONINE-PROTEIN KINASE SMG1
P00018	EGF receptor signaling pathway	P00558	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	15621031	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	RAT|RGD=69319|UniProtKB=P54313	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000035697|UniProtKB=Q28024	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00012	Cadherin signaling pathway	P00470	F-actin	MACMU|Ensembl=ENSMMUG00000001353|UniProtKB=F7D6T8	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00010	B cell activation	P00402	Jnk	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	TAS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000025240|UniProtKB=F7A7I3	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=12774|UniProtKB=P04628	Proto-oncogene Wnt-1	IDA	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00029	Huntington disease	P00775	Rac	SCLS1|Gene=SS1G_13726|UniProtKB=A7F7Z6	Uncharacterized protein	ISS			PTHR24072:SF192	CDC42 HOMOLOG
P00034	Integrin signalling pathway	P00923	Arf1	CANAL|CGD=CAL0003401|UniProtKB=Q5AND9	ADP-ribosylation factor 1	ISS	11752622	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P04393	Ras Pathway	P04570	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	IDA	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IDA	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01192	p110	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00807	Actin	MOUSE|MGI=MGI=87906|UniProtKB=P63260	Actin, cytoplasmic 2	ISS	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	MONDO|Ensembl=ENSMODG00000011796|UniProtKB=F7CBS8	Uncharacterized protein (Fragment)	ISS			PTHR10937:SF2	GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE  ISOMERIZING  1
P06213	DPP signaling pathway	P06293	SOG	DROME|FlyBase=FBgn0003463|UniProtKB=Q24025	Dorsal-ventral patterning protein Sog	IDA	16781701	PubMed	PTHR11339:SF357	DORSAL-VENTRAL PATTERNING PROTEIN SOG
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00057	Wnt signaling pathway	P01446	Calcineurin	MOUSE|MGI=MGI=107162|UniProtKB=P48455	Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform	IDA	7532676	PubMed	PTHR11668:SF186	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT GAMMA ISOFORM
P00017	DNA replication	P00527	Histones	MONDO|Ensembl=ENSMODG00000023677|UniProtKB=F6PGA3	Histone H3	ISS	12413958	PubMed	PTHR11426:SF180	SUBFAMILY NOT NAMED
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=5300|UniProtKB=P47898	5-hydroxytryptamine receptor 5A	IDA	12441358	PubMed	PTHR24247:SF108	5-HYDROXYTRYPTAMINE RECEPTOR 5A
P00047	PDGF signaling pathway	P01143	ERK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00019	Endothelin signaling pathway	P00570	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	MACMU|Ensembl=ENSMMUG00000022596|UniProtKB=F6Z7T2	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF5	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 1
P00019	Endothelin signaling pathway	P00571	Pro ET1-4	PANTR|Ensembl=ENSPTRG00000017730|UniProtKB=H2QSB1	Uncharacterized protein	ISS	15117818	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P00021	FGF signaling pathway	P00632	Akt	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	IGI	14526383	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00049	Parkinson disease	P01212	p38 MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00030	Hypoxia response via HIF activation	P00819	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	CHICK|Ensembl=ENSGALG00000001168|UniProtKB=E1BV97	Uncharacterized protein	ISS	2187864	PubMed	PTHR11800:SF2	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00018	EGF receptor signaling pathway	P00550	Grb2	CAEBR|Gene=CBG16856|UniProtKB=A8XPY6	Protein CBR-SEM-5	ISS	51702266	gi	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00003	Alzheimer disease-amyloid secretase pathway	P00079	alpha7 nicotinic acetylcholine receptor	DROME|FlyBase=FBgn0032151|UniProtKB=Q7KTF8	Nicotinic acetylcholine receptor alpha6, isoform E	IDA			PTHR18945:SF763	NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA6, ISOFORM E
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95818|UniProtKB=Q61626	Glutamate receptor ionotropic, kainate 5	ISS	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	RCA	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	14526383	PubMed	PTHR10048:SF14	PI-3 KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04393	Ras Pathway	P04569	Cdc42	IXOSC|EnsemblGenome=ISCW003614|UniProtKB=B7PHY7	Cdc42 protein, putative	ISS	9658176	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00034	Integrin signalling pathway	P00944	Actin	RAT|RGD=1304556|UniProtKB=P63259	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05913	Enkephalin release	P05977	G-Protein (s)	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00019	Endothelin signaling pathway	P00591	PLCbeta	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00046	Oxidative stress response	P01123	Bcl-2	PANTR|Ensembl=ENSPTRG00000010079|UniProtKB=H2QEM8	B-cell CLL/lymphoma 2	ISS	2250705	PubMed	PTHR11256:SF11	APOPTOSIS REGULATOR BCL-2
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000002647|UniProtKB=F7DIB7	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00013	Cell cycle	P00480	Proteasome	MACMU|Ensembl=ENSMMUG00000020382|UniProtKB=F6UFI7	26S proteasome non-ATPase regulatory subunit 3	ISS	4506229	gi	PTHR10758:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	MACMU|Ensembl=ENSMMUG00000020791|UniProtKB=F7H9Z6	Small-inducible cytokine A27	ISS	11821900	PubMed	PTHR17502:SF4	C-C MOTIF CHEMOKINE 27
P00018	EGF receptor signaling pathway	G01511	SPRY	MOUSE|MGI=MGI=1345144|UniProtKB=Q9WTP2	Protein sprouty homolog 4	ISS	22024232	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04393	Ras Pathway	P04567	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IDA	1171954	gi	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01309	fos	MACMU|Ensembl=ENSMMUG00000010574|UniProtKB=A5A6H2	C-fos	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00005	Angiogenesis	P00223	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CANLF|Ensembl=ENSCAFG00000016020|UniProtKB=O18840	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00017	DNA replication	P00536	DNA Topisomerase	PANTR|Ensembl=ENSPTRG00000014699|UniProtKB=H2QM73	DNA topoisomerase 2	ISS			PTHR10169:SF36	DNA TOPOISOMERASE 2-BETA
P00048	PI3 kinase pathway	P01188	Gbetagamma	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	IC	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000017387|UniProtKB=E2RLD1	Uncharacterized protein	ISS	12507995	PubMed	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00020	FAS signaling pathway	P00611	Gelsolin	CAEEL|WormBase=WBGene00010593|UniProtKB=Q21253	Gelsolin-like protein 1	IGI	9323209	PubMed	PTHR11977:SF39	GELSOLIN
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00627	ERK1-2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00796	Kainate receptor	ORNAN|Ensembl=ENSOANG00000002061|UniProtKB=F7ANC6	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P06664	Gonadotropin-releasing hormone receptor pathway	P06740	BMPR-IA/IB/II	MOUSE|MGI=MGI=1095407|UniProtKB=O35607	Bone morphogenetic protein receptor type-2	RCA	9395284	PubMed	PTHR23255:SF63	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-2
P00034	Integrin signalling pathway	P00912	Arp2/3	MOUSE|MGI=MGI=3648102|UniProtKB=E9Q2K4	Actin-related protein 2/3 complex subunit 5	IPI	12932731	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00223	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01451	Galpha	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00049	Parkinson disease	P01227	20S proteasome	MACMU|Ensembl=ENSMMUG00000005813|UniProtKB=F6VLE9	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF14	PROTEASOME SUBUNIT ALPHA TYPE-5
P00005	Angiogenesis	P00221	JNK1	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00029	Huntington disease	P00784	MAPKK7	PANTR|Ensembl=ENSPTRG00000010409|UniProtKB=H2RBC8	Uncharacterized protein	RCA	15039780	PubMed	PTHR24361:SF387	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04393	Ras Pathway	P04572	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00052	TGF-beta signaling pathway	P01279	Smurfs	CANLF|Ensembl=ENSCAFG00000015133|UniProtKB=F1PQT6	Uncharacterized protein	ISS	11252892	PubMed	PTHR11254:SF293	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P00059	p53 pathway	P01483	Mdm2	HUMAN|HGNC=6974|UniProtKB=O15151	Protein Mdm4	ISS			PTHR13844:SF20	PROTEIN MDM4
P00010	B cell activation	P00402	Jnk	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DROME|FlyBase=FBgn0004623|UniProtKB=P29829	Guanine nucleotide-binding protein subunit beta-2	IC			PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01098	CHT1	RAT|RGD=619711|UniProtKB=P28570	Sodium- and chloride-dependent creatine transporter 1	ISS			PTHR11616:SF96	SODIUM- AND CHLORIDE-DEPENDENT CREATINE TRANSPORTER 1
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	RAT|RGD=1588606|UniProtKB=D4A8A0	DNA fragmentation factor subunit beta	ISS			PTHR11405:SF5	CAD PROTEIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01067	AChE	MACMU|Ensembl=ENSMMUG00000021257|UniProtKB=F7HPD6	Carboxylic ester hydrolase	ISS	86008285	PubMed	PTHR43918:SF3	ACETYLCHOLINESTERASE
P00050	Plasminogen activating cascade	P01254	pro-MMP-13	CANLF|Ensembl=ENSCAFG00000015043|UniProtKB=F1PVS9	Uncharacterized protein	TAS	12834808	PubMed	PTHR10201:SF165	COLLAGENASE 3
P00019	Endothelin signaling pathway	P00572	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00059	p53 pathway	P04609	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	7937853	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000012922|UniProtKB=H2QJF2	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Gene=HTR1E|UniProtKB=Q9N2B6	5-hydroxytryptamine receptor 1E (Fragment)	ISS	11701344	PubMed	PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P00058	mRNA splicing	P01478	U2	CANLF|Ensembl=ENSCAFG00000005520|UniProtKB=E2R2A8	Uncharacterized protein	ISS			PTHR10501:SF21	U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B''
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	IDA	91056091	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00012	Cadherin signaling pathway	P00470	F-actin	RAT|RGD=2027|UniProtKB=P63269	Actin, gamma-enteric smooth muscle	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	HUMAN|HGNC=18539|UniProtKB=P61266	Syntaxin-1B	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P05913	Enkephalin release	P05974	G-Protein (i)	BRAFL|Gene=BRAFLDRAFT_220697|UniProtKB=C3ZSF0	Putative uncharacterized protein	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01425	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00010	B cell activation	P00384	p38	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	RCA			PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	XENTR|Xenbase=XB-GENE-484032|UniProtKB=F6QWD3	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	PANTR|Ensembl=ENSPTRG00000033948|UniProtKB=H2RBD4	Conserved helix-loop-helix ubiquitous kinase	RCA			PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00916	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00004	Alzheimer disease-presenilin pathway	P00117	E-cadherin C-terminal fragment	HUMAN|HGNC=1748|UniProtKB=P12830	Cadherin-1	IDA	12834808	PubMed	PTHR24027:SF319	CADHERIN-1
P04372	5-Hydroxytryptamine degredation	P04401	Monoamine Oxidase	PANTR|Ensembl=ENSPTRG00000021817|UniProtKB=H2QYH6	Amine oxidase [flavin-containing]	ISS	90344230	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00049	Parkinson disease	P01238	14-3-3	ORNAN|Ensembl=ENSOANG00000007305|UniProtKB=F6XW91	Uncharacterized protein	ISS	12615066	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00052	TGF-beta signaling pathway	P01275	P38	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	TAS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00005	Angiogenesis	P00212	EphR	XENTR|Xenbase=XB-GENE-488644|UniProtKB=F7CRM0	Uncharacterized protein (Fragment)	ISS			PTHR24416:SF120	EPHRIN TYPE-B RECEPTOR 3
P00001	Adrenaline and noradrenaline biosynthesis	P00067	MAO	HUMAN|HGNC=6833|UniProtKB=P21397	Amine oxidase [flavin-containing] A	ISS	90344230	PubMed	PTHR43563:SF3	AMINE OXIDASE  FLAVIN-CONTAINING  A
P00048	PI3 kinase pathway	P01189	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00049	Parkinson disease	P01230	Src kinase	MOUSE|MGI=MGI=88537|UniProtKB=P41241	Tyrosine-protein kinase CSK	IDA	12665526	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=3023|UniProtKB=P14416	D(2) dopamine receptor	IDA	1319557	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	TAKRU|Ensembl=ENSTRUG00000008018|UniProtKB=H2T5N4	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	IDA	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00046	Oxidative stress response	P01129	JNK1/2	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00047	PDGF signaling pathway	P01152	RasGAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	14707121	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00029	Huntington disease	P00809	Caspase 6	CHICK|Ensembl=ENSGALG00000012186|UniProtKB=F1NEL6	Uncharacterized protein	IDA	11463840	PubMed	PTHR10454:SF164	CASPASE-6
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	RCA	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00470	F-actin	PHYIT|EnsemblGenome=PITG_15078|UniProtKB=D0NRL5	Actin-like protein	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	PANTR|Ensembl=ENSPTRG00000008770|UniProtKB=H2QC99	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF385	MYOSIN-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	MONDO|Ensembl=ENSMODG00000023683|UniProtKB=F6T0L6	Uncharacterized protein (Fragment)	ISS	11248120	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00022	General transcription by RNA polymerase I	P00657	TBP	SCHPO|PomBase=SPAC29E6.08|UniProtKB=P17871	TATA-box-binding protein	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	CAEEL|WormBase=WBGene00009119|UniProtKB=Q93576	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00021	FGF signaling pathway	P00629	PP2A	RAT|RGD=3380|UniProtKB=P63331	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00164	Nectin 1alpha N-terminal fragment	HUMAN|HGNC=9706|UniProtKB=Q15223	Nectin-1	ISS	12376527	PubMed	PTHR23277:SF69	NECTIN-1
P00021	FGF signaling pathway	P00631	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	4504111	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00053	T cell activation	P01305	Calmodulin	CANLF|Ensembl=ENSCAFG00000016335|UniProtKB=J9NXY2	Uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF322	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00936	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IPI	129387	gi	PTHR10048:SF14	PI-3 KINASE
P05731	GABA-B receptor II signaling	P05754	Ggamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00029	Huntington disease	P00799	JNK-2	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00048	PI3 kinase pathway	P01199	Galpha	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	IC	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CANLF|Ensembl=ENSCAFG00000018832|UniProtKB=E2QYC2	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P02736	Coenzyme A biosynthesis	P02884	Dephospho-CoA kinase	ECOLI|EcoGene=EG12312|UniProtKB=P0A6I9	Dephospho-CoA kinase	ISS			PTHR10695:SF26	BIFUNCTIONAL COENZYME A SYNTHASE
P00010	B cell activation	P00385	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12176041	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00053	T cell activation	P01309	fos	MACMU|Ensembl=ENSMMUG00000010574|UniProtKB=A5A6H2	C-fos	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	HUMAN|HGNC=3373|UniProtKB=Q09472	Histone acetyltransferase p300	ISS	8413673	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	CAEEL|WormBase=WBGene00004860|UniProtKB=Q09488	Serine/threonine-protein kinase sma-6	IDA			PTHR23255:SF68	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00006	Apoptosis signaling pathway	P00269	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00017	DNA replication	P00527	Histones	BOVIN|Ensembl=ENSBTAG00000032452|UniProtKB=P84227	Histone H3.2	ISS	20448842	PubMed	PTHR11426:SF161	HISTONE H3.2-RELATED
P00005	Angiogenesis	P00205	GAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	ISS	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00020	FAS signaling pathway	P00609	FAF1	DANRE|ZFIN=ZDB-GENE-040426-2863|UniProtKB=F1R212	Uncharacterized protein	IGI	8524870	PubMed	PTHR23322:SF52	FAS-ASSOCIATED FACTOR 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	TAKRU|Ensembl=ENSTRUG00000000584|UniProtKB=H2RMN2	Uncharacterized protein	IDA	2039532	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00054	Toll receptor signaling pathway	P01352	p38	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00627	ERK1-2	ARATH|TAIR=AT4G36450|UniProtKB=O23236	Mitogen-activated protein kinase 14	ISS			PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	IGI	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IDA	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00034	Integrin signalling pathway	P00925	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ARATH|TAIR=AT5G05780|UniProtKB=O24412	26S proteasome non-ATPase regulatory subunit 7 homolog A	ISS	15229710	gi	PTHR10540:SF7	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7
P00006	Apoptosis signaling pathway	P00318	PKCs	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00049	Parkinson disease	P01208	Hsp70	CAEEL|WormBase=WBGene00002026|UniProtKB=O45246	Heat Shock Protein	IDA	12150907	PubMed	PTHR19375:SF207	HEAT SHOCK PROTEIN
P00021	FGF signaling pathway	P00640	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IC	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04393	Ras Pathway	P04557	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IDA	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04396	Vitamin D metabolism and pathway	P04603	1alpha-Hydroxylase	BOVIN|Ensembl=ENSBTAG00000016906|UniProtKB=E1BN35	Uncharacterized protein	ISS	10232681	PubMed	PTHR24291:SF3	25-HYDROXYVITAMIN D-1 ALPHA HYDROXYLASE, MITOCHONDRIAL
P00057	Wnt signaling pathway	P01437	TCF	HUMAN|HGNC=6551|UniProtKB=Q9UJU2	Lymphoid enhancer-binding factor 1	IDA	11266476	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00030	Hypoxia response via HIF activation	P00819	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	ANOGA|EnsemblGenome=AGAP012308|UniProtKB=Q7Q083	AGAP012308-PA	ISS			PTHR11482:SF6	ORNITHINE DECARBOXYLASE 1-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00009	Axon guidance mediated by netrin	P00364	cdc42	IXOSC|EnsemblGenome=ISCW003614|UniProtKB=B7PHY7	Cdc42 protein, putative	ISS	9658176	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00052	TGF-beta signaling pathway	P01279	Smurfs	MOUSE|MGI=MGI=1913563|UniProtKB=A2A5Z6	E3 ubiquitin-protein ligase SMURF2	TAS	11252892	PubMed	PTHR11254:SF300	E3 UBIQUITIN-PROTEIN LIGASE SMURF2
P00049	Parkinson disease	P01238	14-3-3	CAEEL|WormBase=WBGene00003920|UniProtKB=P41932	14-3-3-like protein 1	IDA	22318813	PubMed	PTHR18860:SF21	14-3-3-LIKE PROTEIN 1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02913	Thymidylate synthase	DROME|FlyBase=FBgn0024920|UniProtKB=O76511	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00013	Cell cycle	P00484	Cyclin D	BOVIN|Ensembl=ENSBTAG00000017514|UniProtKB=Q2KI22	G1/S-specific cyclin-D1	ISS	12356903	PubMed	PTHR10177:SF67	G1/S-SPECIFIC CYCLIN-D1
P02757	O-antigen biosynthesis	P03049	Glucosamine-1-phosphate acetyltransferase	AQUAE|EnsemblGenome=aq_607|UniProtKB=O66863	Bifunctional protein GlmU	ISS			PTHR43584:SF3	BIFUNCTIONAL PROTEIN GLMU
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	12855688	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00010	B cell activation	P00381	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00018	EGF receptor signaling pathway	P00551	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IGI	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04393	Ras Pathway	P04542	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	NAS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00049	Parkinson disease	P01227	20S proteasome	BOVIN|Ensembl=ENSBTAG00000006564|UniProtKB=Q3T0X5	Proteasome subunit alpha type-1	ISS	12859888	PubMed	PTHR11599:SF12	PROTEASOME SUBUNIT ALPHA TYPE-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2344|UniProtKB=P08485	Muscarinic acetylcholine receptor M4	IDA	8100450	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00021	FGF signaling pathway	P00638	PLCgamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IGI	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	SCHMA|EnsemblGenome=Smp_192110|UniProtKB=G4VHK8	Putative tubulin beta chain	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04633	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	MOUSE|MGI=MGI=1278315|UniProtKB=Q91VN0	Low-density lipoprotein receptor-related protein 5	ISS	11907044	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P05918	p38 MAPK pathway	P06015	p38gamma	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	8925912	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	IC	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	HUMAN|HGNC=414|UniProtKB=P04075	Fructose-bisphosphate aldolase A	ISS	84261525	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00007	Axon guidance mediated by semaphorins	P00340	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06737	p300	MOUSE|MGI=MGI=1276116|UniProtKB=B2RWS6	Histone acetyltransferase p300	RCA	10823891	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P02775	Salvage pyrimidine ribonucleotides	P03151	Uracil phosphoribosyl  transferase	STRCO|EnsemblGenome=CAC32312|UniProtKB=Q9AK76	Uracil phosphoribosyltransferase	ISS			PTHR10285:SF46	URACIL PHOSPHORIBOSYLTRANSFERASE, CHLOROPLASTIC
P00056	VEGF signaling pathway	P01417	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	YEAST|SGD=S000001589|UniProtKB=Q01802	Aspartate aminotransferase, mitochondrial	ISS			PTHR11879:SF10	ASPARTATE AMINOTRANSFERASE
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00046	Oxidative stress response	P01129	JNK1/2	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02742	Tetrahydrofolate biosynthesis	P02951	GTP cyclohydrolase	MOUSE|MGI=MGI=95675|UniProtKB=Q05915	GTP cyclohydrolase 1	ISS			PTHR11109:SF0	GTP CYCLOHYDROLASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	STRPU|EnsemblGenome=SPU_006797|UniProtKB=W4XTP5	Uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00021	FGF signaling pathway	P00634	MEKK1-5	PANTR|Ensembl=ENSPTRG00000016891|UniProtKB=H2R5K3	Uncharacterized protein	ISS	12168099	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	MYCTU|EnsemblGenome=Rv1077|UniProtKB=P9WP51	Putative cystathionine beta-synthase Rv1077	ISS			PTHR10314:SF8	CYSTATHIONINE BETA-SYNTHASE-RELATED
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	DROME|FlyBase=FBgn0030407|UniProtKB=Q9VYL1	Folylpolyglutamate synthase	ISS			PTHR11136:SF5	FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00717	Phosphorylase b	CHICK|Ensembl=ENSGALG00000008508|UniProtKB=E1BSN7	Alpha-1,4 glucan phosphorylase	ISS	4318782	PubMed	PTHR11468:SF1	GLYCOGEN PHOSPHORYLASE, BRAIN FORM
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014555|UniProtKB=F7GT55	Syntaxin-1A isoform 1	ISS	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00029	Huntington disease	P00774	Dynein complex	MACMU|Ensembl=ENSMMUG00000023381|UniProtKB=F7E3Q3	Uncharacterized protein	ISS	9454836	PubMed	PTHR10676:SF344	DYNEIN HEAVY CHAIN 8, AXONEMAL
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P06211	BMP/activin signaling pathway-drosophila	P06244	Furin	DROME|FlyBase=FBgn0004509|UniProtKB=P26016	Furin-like protease 1, isoforms 1/1-X/2	IEA	10956649	PubMed	PTHR42884:SF3	FURIN-LIKE PROTEASE 1, ISOFORMS 1/1-X/2
P00029	Huntington disease	P00805	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00015	Circadian clock system	G01497	cry	CANLF|Ensembl=ENSCAFG00000009379|UniProtKB=F1PNC9	Uncharacterized protein	ISS	10428031	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P05912	Dopamine receptor mediated signaling pathway	P05957	K+ channel	MONDO|Ensembl=ENSMODG00000015769|UniProtKB=F6ZSC2	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MACMU|Ensembl=ENSMMUG00000021610|UniProtKB=F7E433	Regulator of G-protein signaling 10 isoform a	ISS	8756726	PubMed	PTHR10845:SF182	REGULATOR OF G-PROTEIN SIGNALING 10
P00047	PDGF signaling pathway	P01149	MNK1/2	MACMU|Ensembl=ENSMMUG00000011265|UniProtKB=F6WP09	Uncharacterized protein	ISS	11463832	PubMed	PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P00030	Hypoxia response via HIF activation	P00824	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	TAS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00057	Wnt signaling pathway	P01451	Galpha	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	DAPPU|EnsemblGenome=DAPPUDRAFT_206575|UniProtKB=E9FUX0	Guanine nucleotide binding protein, beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00012	Cadherin signaling pathway	P00470	F-actin	TAKRU|Ensembl=ENSTRUG00000005494|UniProtKB=P53483	Actin, alpha anomalous	IC	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00018	EGF receptor signaling pathway	P00551	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IGI	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TRIAD|EnsemblGenome=TriadG63375|UniProtKB=B3S5E4	Non-muscle actin 6.2	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00007	Axon guidance mediated by semaphorins	P00337	Sema3A	XENTR|Xenbase=XB-GENE-966369|UniProtKB=F6XF66	Uncharacterized protein (Fragment)	ISS			PTHR11036:SF23	SEMAPHORIN-3A
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	IC	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00019	Endothelin signaling pathway	P00589	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00021	FGF signaling pathway	P00644	p38	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	IGI	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00036	Interleukin signaling pathway	P00970	Interleukin	MACMU|Ensembl=ENSMMUG00000006691|UniProtKB=F7HK33	Interleukin-17F	ISS			PTHR45214:SF1	INTERLEUKIN-17F
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000005520|UniProtKB=F7GFF0	Cadherin-11 preproprotein	ISS	8120095	PubMed	PTHR24027:SF85	CADHERIN-11
P00052	TGF-beta signaling pathway	P01284	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00036	Interleukin signaling pathway	P00983	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05918	p38 MAPK pathway	P05921	MKP5	RAT|RGD=1310844|UniProtKB=D3ZBG7	Dual specificity phosphatase 10 (Predicted)	ISS	10597297	PubMed	PTHR10159:SF299	DUAL SPECIFICITY PROTEIN PHOSPHATASE 10
P00046	Oxidative stress response	P01129	JNK1/2	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	TAS	7600581	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00049	Parkinson disease	P01211	ERK	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	IDA	12787066	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00012	Cadherin signaling pathway	P00465	TCF/LEF	CANLF|Ensembl=ENSCAFG00000011252|UniProtKB=F1Q334	Uncharacterized protein	ISS	11266476	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P06959	CCKR signaling map	P07033	ROCK1	HUMAN|HGNC=10251|UniProtKB=Q13464	Rho-associated protein kinase 1	RCA	17936584	PubMed	PTHR22988:SF33	RHO-ASSOCIATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	BOVIN|Ensembl=ENSBTAG00000018705|UniProtKB=F1MPC9	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF291	ADENYLATE CYCLASE TYPE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IDA	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00018	EGF receptor signaling pathway	P00556	PLCgamma	CAEBR|Gene=CBG18715|UniProtKB=A8XTZ1	Phosphoinositide phospholipase C	ISS			PTHR10336:SF91	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00021	FGF signaling pathway	P00642	MEK1-2	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IGI	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	BOVIN|Ensembl=ENSBTAG00000003512|UniProtKB=E1BPX8	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF358	MYOSIN-7B
P00047	PDGF signaling pathway	P01164	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	RAT|RGD=621005|UniProtKB=Q08849	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00052	TGF-beta signaling pathway	P01284	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02777	Succinate to proprionate conversion	P03163	Methylmalonyl-CoA decarboxylase	MYCTU|EnsemblGenome=Rv2247|UniProtKB=P9WQH5	Probable propionyl-CoA carboxylase beta chain 6	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CANLF|Ensembl=ENSCAFG00000012125|UniProtKB=E2RR72	Uncharacterized protein	ISS			PTHR19957:SF83	SYNTAXIN-16
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	BOVIN|Gene=ARRB2|UniProtKB=P32120	Beta-arrestin-2	IDA	4757780	gi	PTHR11792:SF20	BETA-ARRESTIN-2
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01351	TLR2,4,7	BOVIN|Gene=TLR4|UniProtKB=Q9GL65	Toll-like receptor 4	ISS			PTHR44568:SF1	TOLL-LIKE RECEPTOR 4
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00006	Apoptosis signaling pathway	P00274	JNK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=19663|UniProtKB=Q9UBI6	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00006	Apoptosis signaling pathway	P00269	MAPK	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04392	P53 pathway feedback loops 1	P04539	p53	HUMAN|HGNC=12003|UniProtKB=O15350	Tumor protein p73	TAS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT1G59580|UniProtKB=Q39022	Mitogen-activated protein kinase 2	ISS	176948	OMIM	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00004	Alzheimer disease-presenilin pathway	P00121	CD44 intracellular fragment	RAT|RGD=2307|UniProtKB=P26051	CD44 antigen	IDA	14871815	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	MACMU|Ensembl=ENSMMUG00000017654|UniProtKB=F6UI32	Beta-arrestin-2 isoform 1	ISS	11742073	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000006999|UniProtKB=E1BDQ4	Uncharacterized protein	ISS	15858232	PubMed	PTHR13715:SF15	RYANODINE RECEPTOR 1
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	CAEBR|Gene=CBG18256|UniProtKB=A8XS95	Protein CBR-ACT-5	ISS	10974003	PubMed	PTHR11937:SF352	ACTIN
P00030	Hypoxia response via HIF activation	P00823	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P06959	CCKR signaling map	P07158	NOS1	HUMAN|HGNC=7872|UniProtKB=P29475	Nitric oxide synthase, brain	RCA	22300432	PubMed	PTHR19384:SF63	NITRIC OXIDE SYNTHASE, BRAIN
P00021	FGF signaling pathway	P00642	MEK1-2	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00053	T cell activation	P01307	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	IPI	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00029	Huntington disease	P00796	Kainate receptor	CHICK|Ensembl=ENSGALG00000001172|UniProtKB=P19439	Probable glutamate receptor	IDA	12941441	PubMed	PTHR18966:SF282	GLUTAMATE RECEPTOR-RELATED
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	SYNY3|EnsemblGenome=BAA17450|UniProtKB=P73410	Cysteine synthase	ISS			PTHR10314:SF159	CYSTEINE SYNTHASE A
P00056	VEGF signaling pathway	P01425	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00321	HSP70	XENTR|Xenbase=XB-GENE-5842877|UniProtKB=F6TJ80	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF310	HEAT SHOCK COGNATE 71 KDA PROTEIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05923	beta-ARR2	BOVIN|Gene=ARRB2|UniProtKB=P32120	Beta-arrestin-2	RCA	12464600	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00034	Integrin signalling pathway	P00927	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P02775	Salvage pyrimidine ribonucleotides	P03149	Cytidine kinase	CAEEL|WormBase=WBGene00008948|UniProtKB=H2L2A8	Uridine kinase	ISS			PTHR10285:SF123	URIDINE KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00245	Rac	HUMAN|HGNC=677|UniProtKB=P85298	Rho GTPase-activating protein 8	ISS			PTHR23176:SF3	PROTEIN PRR5-ARHGAP8-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MONDO|Ensembl=ENSMODG00000005623|UniProtKB=F7CFG8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	RAT|RGD=1309329|UniProtKB=F1MAD0	Protein Lrp5	ISS	11029006	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P06664	Gonadotropin-releasing hormone receptor pathway	P06765	RICS	MOUSE|MGI=MGI=2450166|UniProtKB=Q811P8	Rho GTPase-activating protein 32	RCA			PTHR15729:SF9	RHO GTPASE-ACTIVATING PROTEIN 32
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000029806|UniProtKB=F6V4U3	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF72	PROTOCADHERIN GAMMA-A8
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	HUMAN|HGNC=5967|UniProtKB=Q14626	Interleukin-11 receptor subunit alpha	IC	12569176	PubMed	PTHR23036:SF29	INTERLEUKIN-11 RECEPTOR SUBUNIT ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	9199552	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	STRPU|Gene=CYIIIB|UniProtKB=P18499	Actin, cytoskeletal 3B	IC	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	CANLF|Ensembl=ENSCAFG00000001097|UniProtKB=E2RCX6	Uncharacterized protein	ISS	12890691	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00059	p53 pathway	P01486	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00200	Dsh	HUMAN|HGNC=3087|UniProtKB=Q92997	Segment polarity protein dishevelled homolog DVL-3	ISS	11212302	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DANRE|ZFIN=ZDB-GENE-050417-59|UniProtKB=Q15KE4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00053	T cell activation	P01332	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-486685|UniProtKB=F6VT32	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	TAS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00052	TGF-beta signaling pathway	P01275	P38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00056	VEGF signaling pathway	P01414	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P05918	p38 MAPK pathway	P06041	Cdc42	DANRE|ZFIN=ZDB-GENE-030131-8783|UniProtKB=Q52WY2	Ras-like protein Cdc42a	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CAEBR|Gene=CBG17587|UniProtKB=A8XRA5	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00021	FGF signaling pathway	P00646	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	2574500	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	HUMAN|HGNC=21016|UniProtKB=Q5TDP6	Lengsin	ISS			PTHR43407:SF1	LENGSIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05940	GRK5	HUMAN|HGNC=4544|UniProtKB=P34947	G protein-coupled receptor kinase 5	RCA	8288567	PubMed	PTHR24355:SF27	G PROTEIN-COUPLED RECEPTOR KINASE 5
P00004	Alzheimer disease-presenilin pathway	P00128	Erb-B4	MOUSE|MGI=MGI=104771|UniProtKB=Q61527	Receptor tyrosine-protein kinase erbB-4	ISS	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00029	Huntington disease	P00780	Microtubule	CANLF|Ensembl=ENSCAFG00000000443|UniProtKB=E2QSF4	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P05918	p38 MAPK pathway	P06013	ELK	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	RCA	12660819	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00057	Wnt signaling pathway	P01447	Dishevelled	PANTR|Ensembl=ENSPTRG00000015681|UniProtKB=H2QNU7	Dishevelled, dsh homolog 3	ISS	10409711	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P04398	p53 pathway feedback loops 2	P04651	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P04393	Ras Pathway	P04565	MKK4/7	MONDO|Ensembl=ENSMODG00000008266|UniProtKB=F6Z879	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00470	F-actin	RAT|RGD=1304556|UniProtKB=P63259	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00023	General transcription regulation	P00658	TBP-associated factors	ORYSJ|EnsemblGenome=OS01G0510800|UniProtKB=Q8LRG9	Os01g0510800 protein	ISS	12447438	PubMed	PTHR10221:SF9	TAF6-LIKE RNA POLYMERASE II P300/CBP-ASSOCIATED FACTOR-ASSOCIATED FACTOR 65 KDA SUBUNIT 6L
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	PANTR|Ensembl=ENSPTRG00000015034|UniProtKB=H2QMT4	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00048	PI3 kinase pathway	P01206	14-3-3	DROME|FlyBase=FBgn0004907|UniProtKB=P29310	14-3-3 protein zeta	ISS	10407019	PubMed	PTHR18860:SF13	14-3-3 PROTEIN ZETA
P02736	Coenzyme A biosynthesis	P02882	Pantothenate cysteine ligase	STRCO|Gene=CAD55280|UniProtKB=Q8CK27	Putative flavoprotein homologue (Partial)	ISS			PTHR14359:SF6	PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE
P00052	TGF-beta signaling pathway	P01284	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PRIPA|Gene=PPA19914|UniProtKB=H3FCG4	Uncharacterized protein	ISS			PTHR11937:SF359	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	CAEBR|Gene=CBG_05938|UniProtKB=H8WGV2	Protein CBR-ITR-1, isoform a	ISS	9065779	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00057	Wnt signaling pathway	P01465	Ggamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00036	Interleukin signaling pathway	P00962	ELK	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	10487205	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00009	Axon guidance mediated by netrin	P00363	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02747	Histidine biosynthesis	P02987	ATP phosphoribosyl transferase	THEMA|EnsemblGenome=TM_1042|UniProtKB=Q9X0D2	ATP phosphoribosyltransferase	ISS			PTHR21403:SF4	ATP PHOSPHORIBOSYLTRANSFERASE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00629	PP2A	BOVIN|Ensembl=ENSBTAG00000020192|UniProtKB=A4FV55	PPP2R5C protein	ISS	8576224	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P04384	Gamma-aminobutyric acid synthesis	P04482	Glutamate decarboxylase	DROME|FlyBase=FBgn0004516|UniProtKB=P20228	Glutamate decarboxylase	ISS	2247446	PubMed	PTHR11999:SF137	GLUTAMATE DECARBOXYLASE
P04393	Ras Pathway	P04555	PDK	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P06664	Gonadotropin-releasing hormone receptor pathway	P06773	gnai/o	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	RCA	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P02761	Pantothenate biosynthesis	P03068	Pantoate-beta-alanine ligase	YEAST|SGD=S000001407|UniProtKB=P40459	Pantoate--beta-alanine ligase	ISS			PTHR21299:SF1	PANTOATE--BETA-ALANINE LIGASE
P00053	T cell activation	P01322	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00924	Raf	MOUSE|MGI=MGI=88190|UniProtKB=P28028	Serine/threonine-protein kinase B-raf	IPI	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00037	Ionotropic glutamate receptor pathway	P01023	CaMKII	XENTR|Xenbase=XB-GENE-868293|UniProtKB=F6UQZ6	Uncharacterized protein	ISS	12888804	PubMed	PTHR43940:SF4	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT DELTA
P00037	Ionotropic glutamate receptor pathway	P01005	NR2D	RAT|RGD=2740|UniProtKB=Q62645	Glutamate receptor ionotropic, NMDA 2D	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00004	Alzheimer disease-presenilin pathway	P00114	actin	XENTR|Xenbase=XB-GENE-493937|UniProtKB=Q5M8T9	Actin, alpha 2, smooth muscle, aorta	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00048	PI3 kinase pathway	P01199	Galpha	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00046	Oxidative stress response	P01127	eEF2K	CAEEL|WormBase=WBGene00001160|UniProtKB=O01991	Eukaryotic elongation factor 2 kinase	TAS	11500363	PubMed	PTHR14187:SF56	EUKARYOTIC ELONGATION FACTOR 2 KINASE
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00046	Oxidative stress response	P01129	JNK1/2	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00702	CPB	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	RCA			PTHR13808:SF5	CREB-BINDING PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	DANRE|ZFIN=ZDB-GENE-040718-276|UniProtKB=F1Q9W6	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF26	REGULATOR OF G-PROTEIN SIGNALING 7
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P02746	Heme biosynthesis	P02980	Coproporphyrinogen Oxidase (oxygen dependent)	ARATH|TAIR=AT1G03475|UniProtKB=Q9LR75	Coproporphyrinogen-III oxidase 1, chloroplastic	ISS			PTHR10755:SF0	OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PANTR|Ensembl=ENSPTRG00000008766|UniProtKB=H2QC97	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF504	MYOSIN-13
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	PANTR|Ensembl=ENSPTRG00000013825|UniProtKB=H2RAK4	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	IGI	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00054	Toll receptor signaling pathway	P01352	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00049	Parkinson disease	P01238	14-3-3	ORNAN|Ensembl=ENSOANG00000003572|UniProtKB=F7DGH9	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00021	FGF signaling pathway	P00643	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04665	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01461	FrzB	HUMAN|HGNC=10778|UniProtKB=Q6FHJ7	Secreted frizzled-related protein 4	IDA	9118218	PubMed	PTHR11309:SF7	SECRETED FRIZZLED-RELATED PROTEIN 4
P00049	Parkinson disease	G01547	DAT	RAT|RGD=3715|UniProtKB=P23977	Sodium-dependent dopamine transporter	IDA	92107910	PubMed	PTHR11616:SF38	SODIUM-DEPENDENT DOPAMINE TRANSPORTER
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02776	Serine glycine biosynthesis	P03160	Phosphoglycerate dehydrogenase	BACSU|EnsemblGenome=BSU23070|UniProtKB=P35136	D-3-phosphoglycerate dehydrogenase	ISS			PTHR42938:SF9	FORMATE DEHYDROGENASE 1-RELATED
P00049	Parkinson disease	P01236	Casein kinase II	DROME|FlyBase=FBgn0264492|UniProtKB=P08181	Casein kinase II subunit alpha	ISS	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P04393	Ras Pathway	P04546	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PUCGT|EnsemblGenome=PGTG_05488|UniProtKB=E3K4I1	Actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00051	TCA cycle	P01267	Citrate Synthase	YEAST|SGD=S000000598|UniProtKB=P08679	Citrate synthase, peroxisomal	ISS	3540614	PubMed	PTHR11739:SF8	CITRATE SYNTHASE, MITOCHONDRIAL
P04395	Vasopressin synthesis	P04597	Signal Peptide	HUMAN|HGNC=8528|UniProtKB=P01178	Oxytocin-neurophysin 1	ISS	3768139	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00053	T cell activation	P01330	IKK	CANLF|Ensembl=ENSCAFG00000009588|UniProtKB=E2RNA9	Uncharacterized protein	ISS	12813046	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	176910	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00807	Actin	ANOGA|EnsemblGenome=AGAP001676|UniProtKB=Q7PXZ8	AGAP001676-PA	IDA	14684598	PubMed	PTHR11937:SF368	ACTIN, INDIRECT FLIGHT MUSCLE
P00049	Parkinson disease	P01234	GRK	TAKRU|Ensembl=ENSTRUG00000018612|UniProtKB=H2VEM3	Protein-serine/threonine kinase	ISS	10852916	PubMed	PTHR24355:SF18	PROTEIN-SERINE/THREONINE KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	IDA	12787066	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00019	Endothelin signaling pathway	P00591	PLCbeta	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00021	FGF signaling pathway	P00634	MEKK1-5	HUMAN|HGNC=6856|UniProtKB=Q9Y6R4	Mitogen-activated protein kinase kinase kinase 4	IGI	12878610	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05913	Enkephalin release	P05972	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00010	B cell activation	P00368	vav	MACMU|Ensembl=ENSMMUG00000017214|UniProtKB=F7HEA0	Uncharacterized protein	ISS	14623913	PubMed	PTHR22826:SF95	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DROME|FlyBase=FBgn0024846|UniProtKB=O61443	Mitogen-activated protein kinase 14B	TAS			PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00018	EGF receptor signaling pathway	P00562	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00047	PDGF signaling pathway	P01145	c-fos	CANLF|Ensembl=ENSCAFG00000017040|UniProtKB=E2QYK5	Uncharacterized protein	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04393	Ras Pathway	P04558	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IDA	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05918	p38 MAPK pathway	P06025	SRF	MOUSE|MGI=MGI=106658|UniProtKB=Q9JM73	Serum response factor	ISS	15170389	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02727	Androgen/estrogene/progesterone biosynthesis	P02828	Aromatase	MOUSE|MGI=MGI=88587|UniProtKB=P28649	Aromatase	RCA			PTHR24291:SF43	AROMATASE
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01314	nck	MOUSE|MGI=MGI=1306821|UniProtKB=O55033	Cytoplasmic protein NCK2	ISS	12874226	PubMed	PTHR44108:SF1	CYTOPLASMIC PROTEIN NCK2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ORYSJ|EnsemblGenome=OS05G0438800|UniProtKB=Q75HX0	Actin	IDA	10974003	PubMed	PTHR11937:SF248	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	DANRE|ZFIN=ZDB-GENE-991207-24|UniProtKB=Q9PVF8	Catenin (Cadherin-associated protein), alpha	TAS	9362521	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00053	T cell activation	P01318	PKC-theta	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12701063	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00029	Huntington disease	P00786	ARF	PUCGT|EnsemblGenome=PGTG_00026|UniProtKB=E3JPY7	ADP-ribosylation factor	ISS	12932731	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00018	EGF receptor signaling pathway	P00564	Rac	CAEEL|WormBase=WBGene00000424|UniProtKB=Q03206	Ras-related protein ced-10	ISS	21643963	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IDA	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00054	Toll receptor signaling pathway	P01354	NFkappaB	RAT|RGD=1307189|UniProtKB=Q5U2Z4	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	ISS	12574369	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	MOUSE|MGI=MGI=95602|UniProtKB=P39688	Tyrosine-protein kinase Fyn	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00053	T cell activation	P01320	PLC-gamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00005	Angiogenesis	P00249	PAK	BOVIN|Ensembl=ENSBTAG00000010191|UniProtKB=Q08E52	Serine/threonine-protein kinase PAK 1	ISS	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00019	Endothelin signaling pathway	P00566	ERK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	NAS	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	CANLF|Gene=CGA|UniProtKB=Q9XSW8	Glycoprotein hormones alpha chain	ISS	89325834	PubMed	PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P00056	VEGF signaling pathway	P01408	Akt/PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	CANLF|Ensembl=ENSCAFG00000003333|UniProtKB=F1PWT6	Uncharacterized protein	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	IDA	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00020	FAS signaling pathway	P00615	JNK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	TAS	11007936	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00059	p53 pathway	P01481	ATM/ATR	SCHPO|PomBase=SPCC23B6.03c|UniProtKB=O74630	Serine/threonine-protein kinase tel1	ISS			PTHR11139:SF72	SERINE-PROTEIN KINASE ATM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00046	Oxidative stress response	P01126	ATF2	MOUSE|MGI=MGI=109349|UniProtKB=P16951	Cyclic AMP-dependent transcription factor ATF-2	TAS	10664585	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00056	VEGF signaling pathway	P01408	Akt/PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00944	Actin	MONDO|Ensembl=ENSMODG00000012036|UniProtKB=F7ALP1	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00036	Interleukin signaling pathway	P00980	IRS1/2	HUMAN|HGNC=6126|UniProtKB=Q9Y4H2	Insulin receptor substrate 2	IC	5031805	gi	PTHR10614:SF7	INSULIN RECEPTOR SUBSTRATE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	TAKRU|Ensembl=ENSTRUG00000014419|UniProtKB=H2UIU6	Uncharacterized protein	ISS	12473693	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00047	PDGF signaling pathway	P01174	Rho	MACMU|Ensembl=ENSMMUG00000022603|UniProtKB=F6Z7C0	Uncharacterized protein	ISS			PTHR12552:SF3	RHO GTPASE-ACTIVATING PROTEIN 42
P04393	Ras Pathway	P04556	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	MOUSE|MGI=MGI=95794|UniProtKB=A2ARV4	Low-density lipoprotein receptor-related protein 2	ISS	11907044	PubMed	PTHR44025:SF5	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02918	dUTP pyrophosphatase	PANTR|Ensembl=ENSPTRG00000007044|UniProtKB=H2R8E7	Deoxyuridine triphosphatase	ISS			PTHR11241:SF6	DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE, MITOCHONDRIAL
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	PANTR|Ensembl=ENSPTRG00000005858|UniProtKB=H2Q7J6	Uncharacterized protein	ISS	11859080	PubMed	PTHR24247:SF30	5-HYDROXYTRYPTAMINE RECEPTOR 2A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00875	GEF	CANLF|Ensembl=ENSCAFG00000018590|UniProtKB=E2RGT8	Uncharacterized protein	ISS	14623913	PubMed	PTHR22826:SF112	PROTO-ONCOGENE VAV
P04393	Ras Pathway	P04550	Ral	TAKRU|Ensembl=ENSTRUG00000013360|UniProtKB=H2UAT5	Uncharacterized protein	ISS			PTHR24070:SF174	RAS-RELATED PROTEIN RAL-A
P05731	GABA-B receptor II signaling	P05754	Ggamma	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000002016|UniProtKB=F1P3G1	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	EMENI|EnsemblGenome=CADANIAG00000041|UniProtKB=G5EB79	Pyrroline-5-carboxylate reductase	ISS			PTHR11645:SF0	PYRROLINE-5-CARBOXYLATE REDUCTASE
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95777|UniProtKB=Q6R0H7	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas	IC	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00017	DNA replication	P00527	Histones	MACMU|Ensembl=ENSMMUG00000029868|UniProtKB=F7CPH7	Histone H3	ISS	20448842	PubMed	PTHR11426:SF161	HISTONE H3.2-RELATED
P00011	Blood coagulation	P00430	FX	ORNAN|Ensembl=ENSOANG00000015639|UniProtKB=F7FYL8	Uncharacterized protein	ISS	9837158	gi	PTHR44064:SF3	COAGULATION FACTOR X
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	IDA	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P04398	p53 pathway feedback loops 2	P04657	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04561	SRF	HUMAN|HGNC=11291|UniProtKB=P11831	Serum response factor	IDA	15326221	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MONDO|Ensembl=ENSMODG00000006241|UniProtKB=F7FRY0	Ribosomal protein S6 kinase	ISS	1922062	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P04393	Ras Pathway	P04564	MAPKAP	BOVIN|Ensembl=ENSBTAG00000016532|UniProtKB=Q3SYZ2	MAP kinase-activated protein kinase 3	ISS	11335727	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P02788	Xanthine and guanine salvage pathway	P03245	Guanine phosphoribosyl transferase	LEIMA|EnsemblGenome=LmjF.21.0850|UniProtKB=Q4QCC2	Xanthine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00059	p53 pathway	P01480	PTEN	ARATH|TAIR=AT5G39400|UniProtKB=Q9FLZ5	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN1	ISS			PTHR12305:SF80	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND PROTEIN-TYROSINE-PHOSPHATASE PTEN1
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	DROME|FlyBase=FBgn0001269|UniProtKB=P05527	Homeobox protein invected	IEP	12356903	PubMed	PTHR24341:SF6	HOMEOBOX PROTEIN INVECTED-RELATED
P00018	EGF receptor signaling pathway	P00560	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	MONDO|Ensembl=ENSMODG00000004410|UniProtKB=F6SV58	Uncharacterized protein	ISS			PTHR23050:SF322	SUBFAMILY NOT NAMED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05938	RhoA	XENTR|Xenbase=XB-GENE-941426|UniProtKB=Q28HZ4	Novel Rho protein	ISS	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00049	Parkinson disease	P01219	SAPK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02734	Chorismate biosynthesis	P02869	3-Dehydroquinate dehydratase	METAC|EnsemblGenome=MA_4593|UniProtKB=Q8THC4	3-dehydroquinate dehydratase	ISS			PTHR43699:SF1	3-DEHYDROQUINATE DEHYDRATASE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	RCA	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00029	Huntington disease	P00777	CBP	ARATH|TAIR=AT1G16710|UniProtKB=Q9FWQ5	Histone acetyltransferase HAC12	IDA	8413673	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00012	Cadherin signaling pathway	P00475	Frizzled	RAT|RGD=2321905|UniProtKB=D4ACM8	Protein Fzd7	ISS	11212302	PubMed	PTHR11309:SF31	FRIZZLED-7
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000005792|UniProtKB=F6VTR8	Uncharacterized protein	ISS	129387	gi	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	88234494	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	HUMAN|HGNC=4594|UniProtKB=Q14416	Metabotropic glutamate receptor 2	ISS	12351712	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00010	B cell activation	P00384	p38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	MOUSE|MGI=MGI=101931|UniProtKB=P43006	Excitatory amino acid transporter 2	ISS	94365697	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P02751	Lysine biosynthesis	P03006	Dihydrodipicolinate  reductase	BACTN|EnsemblGenome=BT_3320|UniProtKB=Q8A2I5	Dihydrodipicolinate reductase	ISS			PTHR20836:SF0	DIHYDRODIPICOLINATE REDUCTASE-LIKE PROTEIN CRR1, CHLOROPLASTIC
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CHICK|Ensembl=ENSGALG00000028612|UniProtKB=F1P3X1	Uncharacterized protein	IC	10938134	PubMed	PTHR13140:SF728	MYOSIN HEAVY CHAIN, SKELETAL MUSCLE, ADULT
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MACMU|Ensembl=ENSMMUG00000006921|UniProtKB=F7EV26	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02770	Pyridoxal phosphate salvage pathway	P03121	Pyridoxal kinase	RAT|RGD=1566085|UniProtKB=D3Z8P5	Protein RGD1566085	ISS	20344886	gi	PTHR10534:SF2	PYRIDOXAL KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS			PTHR13808:SF5	CREB-BINDING PROTEIN
P02751	Lysine biosynthesis	P03006	Dihydrodipicolinate  reductase	BACSU|EnsemblGenome=BSU22490|UniProtKB=P42976	4-hydroxy-tetrahydrodipicolinate reductase	ISS			PTHR20836:SF0	DIHYDRODIPICOLINATE REDUCTASE-LIKE PROTEIN CRR1, CHLOROPLASTIC
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00011	Blood coagulation	P00404	PAR-1	PANTR|Ensembl=ENSPTRG00000017004|UniProtKB=H2QR41	Coagulation factor II (Thrombin) receptor	ISS	3024720	gi	PTHR24232:SF20	PROTEINASE-ACTIVATED RECEPTOR 1
P06959	CCKR signaling map	G07270	PAI2	HUMAN|HGNC=8584|UniProtKB=P05120	Plasminogen activator inhibitor 2	RCA	14996729	PubMed	PTHR11461:SF61	PLASMINOGEN ACTIVATOR INHIBITOR 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CHICK|Ensembl=ENSGALG00000013785|UniProtKB=E1BS74	Uncharacterized protein	ISS	2106672	PubMed	PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00029	Huntington disease	P00786	ARF	ORYSJ|EnsemblGenome=OS03G0811900|UniProtKB=Q7XZG0	ADP-ribosylation factor	IPI	12932731	PubMed	PTHR11711:SF215	SUBFAMILY NOT NAMED
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00021	FGF signaling pathway	P00645	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01318	PKC-theta	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	7937853	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IDA	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00541	Spry	CANLF|Ensembl=ENSCAFG00000005260|UniProtKB=E2RGU9	Uncharacterized protein	ISS	12815057	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00018	EGF receptor signaling pathway	P00558	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CAEBR|Gene=CBG17587|UniProtKB=A8XRA5	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00053	T cell activation	P01294	NFAT	MACMU|Ensembl=ENSMMUG00000021843|UniProtKB=F6RNI3	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00217	STAT3	CANLF|Ensembl=ENSCAFG00000015213|UniProtKB=E2RB82	Signal transducer and activator of transcription	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P06664	Gonadotropin-releasing hormone receptor pathway	P06841	gnaq/11	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	RCA	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00029	Huntington disease	P00780	Microtubule	XENTR|Xenbase=XB-GENE-491459|UniProtKB=L7N3Q3	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=620146|UniProtKB=O08874	Serine/threonine-protein kinase N2	ISS	11880265	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00005	Angiogenesis	P00243	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	BOVIN|Ensembl=ENSBTAG00000006136|UniProtKB=E1BNY1	Uncharacterized protein	ISS			PTHR11644:SF2	CYTIDINE DEAMINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	IC	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	YEAST|SGD=S000000028|UniProtKB=P31109	Synaptobrevin homolog 1	ISS	14997396	PubMed	PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00034	Integrin signalling pathway	P00927	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00048	PI3 kinase pathway	P01177	P110ACT	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=1197020|UniProtKB=O35468	Protein Wnt-9b	IDA	8717036	PubMed	PTHR12027:SF84	PROTEIN WNT-9B
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000020887|UniProtKB=F1MP22	Uncharacterized protein	ISS	14624853	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P04397	p53 pathway by glucose deprivation	P04636	S6K	MONDO|Ensembl=ENSMODG00000014313|UniProtKB=F7BTW0	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	MOUSE|MGI=MGI=87905|UniProtKB=P68033	Actin, alpha cardiac muscle 1	IC	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P05916	Opioid prodynorphin pathway	P06002	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00924	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00059	p53 pathway	P04609	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00005	Angiogenesis	P00206	Wnt	MACMU|Ensembl=ENSMMUG00000007765|UniProtKB=F7CW57	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02913	Thymidylate synthase	YEAST|SGD=S000005600|UniProtKB=P06785	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P02762	Pentose phosphate pathway	P03081	Transaldolase	ECOLI|EcoGene=EG11905|UniProtKB=P32669	Fructose-6-phosphate aldolase 2	IDA			PTHR10683:SF18	TRANSALDOLASE
P02750	Lipoate_biosynthesis	P03003	Lipoyl-protein ligase	ARATH|TAIR=AT4G31050|UniProtKB=Q948J9	Plastidial lipoyltransferase 2	ISS			PTHR10993:SF11	PLASTIDIAL LIPOYLTRANSFERASE 2-RELATED
P00054	Toll receptor signaling pathway	P01360	IKKbeta	HUMAN|HGNC=5960|UniProtKB=O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01179	PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	IDA	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	MOUSE|MGI=MGI=94926|UniProtKB=P51436	D(4) dopamine receptor	ISS	11248120	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00021	FGF signaling pathway	P00629	PP2A	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g195622|UniProtKB=A7T2Q5	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00057	Wnt signaling pathway	P01437	TCF	PANTR|Ensembl=ENSPTRG00000012128|UniProtKB=H2QI87	Uncharacterized protein	ISS	9118222	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P04393	Ras Pathway	P04557	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	IDA	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	CHICK|Ensembl=ENSGALG00000023961|UniProtKB=O42220	Growth/differentiation factor 8	TAS	9759503	PubMed	PTHR11848:SF150	GROWTH/DIFFERENTIATION FACTOR 8
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00053	T cell activation	P01333	cdc42	TAKRU|Ensembl=ENSTRUG00000008289|UniProtKB=H2T7U8	Uncharacterized protein	ISS	11027488	PubMed	PTHR24072:SF129	CDC42L PROTEIN
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	IPI	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05913	Enkephalin release	P05974	G-Protein (i)	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	11535291	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00057	Wnt signaling pathway	P01457	GBeta	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IDA	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04393	Ras Pathway	P04552	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DROME|FlyBase=FBgn0030011|UniProtKB=Q9W3J1	Gbeta5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00005	Angiogenesis	P00206	Wnt	DROME|FlyBase=FBgn0004360|UniProtKB=P28465	Protein Wnt-2	ISS	11266476	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00047	PDGF signaling pathway	P01143	ERK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS			PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00036	Interleukin signaling pathway	P00981	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00057	Wnt signaling pathway	P01472	Histone deacetylase	DANRE|ZFIN=ZDB-GENE-020419-32|UniProtKB=F1R653	Histone deacetylase	IDA	10485845	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00005	Angiogenesis	P00243	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	BOVIN|Ensembl=ENSBTAG00000000917|UniProtKB=E1BEV7	Metalloendopeptidase	ISS	9759503	PubMed	PTHR43978:SF3	BONE MORPHOGENETIC PROTEIN 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02749	Leucine biosynthesis	P03001	3-Isopropylmalate dehydrogenase	YEAST|SGD=S000000523|UniProtKB=P04173	3-isopropylmalate dehydrogenase	ISS			PTHR42979:SF1	3-ISOPROPYLMALATE DEHYDROGENASE
P04397	p53 pathway by glucose deprivation	P04645	TSC1	MOUSE|MGI=MGI=1929183|UniProtKB=Q9EP53	Hamartin	ISS	12820960	PubMed	PTHR15154:SF2	HAMARTIN
P05918	p38 MAPK pathway	P06021	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12676940	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00048	PI3 kinase pathway	P01185	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00052	TGF-beta signaling pathway	P01275	P38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00045	Notch signaling pathway	P01110	Presenilin	MACMU|Ensembl=ENSMMUG00000010173|UniProtKB=F7AGU8	Presenilin	ISS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00010	B cell activation	P00384	p38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IDA	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00059	p53 pathway	P04609	PI3K	CAEEL|WormBase=WBGene00006932|UniProtKB=Q9TXI7	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00007	Axon guidance mediated by semaphorins	P00333	RhoGEF	PANTR|Ensembl=ENSPTRG00000011039|UniProtKB=H2QGF2	Uncharacterized protein	ISS	12123608	PubMed	PTHR12673:SF122	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00029	Huntington disease	P00788	Calpain	PANTR|Ensembl=ENSPTRG00000002016|UniProtKB=H2Q170	Calpain 2, (M/II) large subunit	ISS	11675509	PubMed	PTHR10183:SF268	CALPAIN-2 CATALYTIC SUBUNIT
P00049	Parkinson disease	P01219	SAPK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00845	Cyclooxygenase	RAT|RGD=620349|UniProtKB=P35355	Prostaglandin G/H synthase 2	ISS	93357029	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	RAT|RGD=2846|UniProtKB=P28564	5-hydroxytryptamine receptor 1B	ISS	12441358	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DANRE|ZFIN=ZDB-GENE-000322-1|UniProtKB=Q9I8V1	Actin, alpha 1, skeletal muscle	IC	10974003	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00005	Angiogenesis	P00223	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00380	fos	CANLF|Ensembl=ENSCAFG00000017040|UniProtKB=E2QYK5	Uncharacterized protein	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MONDO|Ensembl=ENSMODG00000012331|UniProtKB=F7E2P1	Phosphoinositide phospholipase C	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P00005	Angiogenesis	P00186	FGFR-1	BOVIN|Ensembl=ENSBTAG00000015457|UniProtKB=A4IFL5	Fibroblast growth factor receptor	ISS	9763444	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04393	Ras Pathway	P04566	Stat 1/3	PANTR|Ensembl=ENSPTRG00000009200|UniProtKB=H2QD20	Signal transducer and activator of transcription	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00034	Integrin signalling pathway	P00941	Integrin alpha	BOVIN|Ensembl=ENSBTAG00000009256|UniProtKB=F1MEF6	Uncharacterized protein	IPI	3487386	PubMed	PTHR23220:SF78	INTEGRIN ALPHA-4
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00029	Huntington disease	P00778	NMDA receptor	DANRE|ZFIN=ZDB-GENE-051202-2|UniProtKB=Q6ZM67	Uncharacterized protein	ISS	11319238	PubMed	PTHR44391:SF3	SUBFAMILY NOT NAMED
P00016	Cytoskeletal regulation by Rho GTPase	P00510	mDia	MOUSE|MGI=MGI=1927222|UniProtKB=Q9Z207	Protein diaphanous homolog 3	ISS			PTHR23213:SF198	PROTEIN DIAPHANOUS HOMOLOG 3
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00005	Angiogenesis	P00256	PLC-gamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04393	Ras Pathway	P04560	AP1	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00010	B cell activation	P00401	jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	12972619	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PHYPA|Gene=PHYPADRAFT_121199|UniProtKB=A9RY37	Predicted protein	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00012	Cadherin signaling pathway	P00474	Wnt	CAEEL|WormBase=WBGene00000858|UniProtKB=P34889	Protein Wnt-2	IDA	11266476	PubMed	PTHR12027:SF77	PROTEIN WNT-5
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	LEIMA|EnsemblGenome=LmjF.04.1210|UniProtKB=O96999	Putative casein kinase I	IDA	10617630	PubMed	PTHR11909:SF292	SUBFAMILY NOT NAMED
P00046	Oxidative stress response	P01129	JNK1/2	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01432	Beta-Catenin	CHICK|Ensembl=ENSGALG00000011905|UniProtKB=F1NHT7	Uncharacterized protein	IDA	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	TAS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04393	Ras Pathway	P04578	Rho	RAT|RGD=621309|UniProtKB=P62747	Rho-related GTP-binding protein RhoB	ISS	11973360	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00034	Integrin signalling pathway	P00942	Fyn	TAKRU|Ensembl=ENSTRUG00000014739|UniProtKB=H2UL58	Tyrosine-protein kinase	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CANLF|Ensembl=ENSCAFG00000018530|UniProtKB=F1PXD3	Uncharacterized protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02738	De novo purine biosynthesis	P02908	Phosphoribosylamine glycine ligase	MOUSE|MGI=MGI=95654|UniProtKB=Q64737	Trifunctional purine biosynthetic protein adenosine-3	ISS			PTHR10520:SF10	TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3
P00053	T cell activation	P01298	NFkappaB	RAT|RGD=1307189|UniProtKB=Q5U2Z4	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	ISS	9133421	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	DANRE|ZFIN=ZDB-GENE-021120-3|UniProtKB=Q90ZZ7	Aldehyde dehydrogenase	ISS			PTHR43570:SF2	ALDEHYDE DEHYDROGENASE FAMILY 3 MEMBER B1
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05977	G-Protein (s)	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MOUSE|MGI=MGI=1309999|UniProtKB=Q922R0	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00023	General transcription regulation	P00669	TFIIEalpha	CANLF|Ensembl=ENSCAFG00000011306|UniProtKB=E2R3P2	Uncharacterized protein	ISS	189964	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P05731	GABA-B receptor II signaling	P05755	Gbeta	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P02785	Valine biosynthesis	P03215	Branched chain amino acid aminotransferase	MACMU|Ensembl=ENSMMUG00000010079|UniProtKB=F6ZG15	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF39	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, MITOCHONDRIAL
P00019	Endothelin signaling pathway	P00591	PLCbeta	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04393	Ras Pathway	P04559	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	8649368	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00055	Transcription regulation by bZIP transcription factor	P01390	TFIIA complex	MOUSE|MGI=MGI=1919078|UniProtKB=Q8R4I4	TFIIA-alpha and beta-like factor	ISS			PTHR12694:SF9	PROTEIN STON1-GTF2A1L-RELATED
P00018	EGF receptor signaling pathway	P00558	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IGI	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00018	EGF receptor signaling pathway	P00560	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02728	Arginine biosynthesis	P02842	N-acetylornithine aminotransferase	SCHPO|PomBase=SPCC777.09c|UniProtKB=O74548	Probable acetylornithine aminotransferase, mitochondrial	ISS	10074354	PubMed	PTHR11986:SF79	ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00037	Ionotropic glutamate receptor pathway	P01006	NR2C	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	ISS			PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P06210	Activin beta signaling pathway	P06237	PPM1A	DROME|FlyBase=FBgn0086361|UniProtKB=Q961C5	Alphabet, isoform E	IEA	http://flybase.org/reports/FBgn0086361.html	Website	PTHR13832:SF524	PROTEIN PHOSPHATASE 1A, MAGNESIUM DEPENDENT, ALPHA ISOFORM-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	CAEEL|WormBase=WBGene00004860|UniProtKB=Q09488	Serine/threonine-protein kinase sma-6	TAS	10683140	PubMed	PTHR23255:SF68	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00012	Cadherin signaling pathway	P00470	F-actin	PRIPA|Gene=PPA23459|UniProtKB=H3FMF2	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00009	Axon guidance mediated by netrin	P00363	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00012	Cadherin signaling pathway	P00470	F-actin	RAT|RGD=628837|UniProtKB=P60711	Actin, cytoplasmic 1	IC	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00034	Integrin signalling pathway	P00907	ERK	HUMAN|HGNC=6879|UniProtKB=Q16659	Mitogen-activated protein kinase 6	ISS	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00036	Interleukin signaling pathway	P00964	p90RSK	CANLF|Ensembl=ENSCAFG00000000828|UniProtKB=F6UWI0	Ribosomal protein S6 kinase	ISS	15526037	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	CHICK|Ensembl=ENSGALG00000015896|UniProtKB=F1NX42	Uncharacterized protein	TAS	12834808	PubMed	PTHR10201:SF26	MATRIX METALLOPROTEINASE-16
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05913	Enkephalin release	P05972	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00049	Parkinson disease	P01211	ERK	ORYSJ|EnsemblGenome=OS03G0285800|UniProtKB=Q10N20	Mitogen-activated protein kinase 5	ISS			PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00048	PI3 kinase pathway	P01177	P110ACT	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00819	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00010	B cell activation	P00371	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01438	PP2A	IXOSC|EnsemblGenome=ISCW014549|UniProtKB=B7QGY5	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	STRPU|EnsemblGenome=SPU_014285|UniProtKB=W4YEV4	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01455	Smad4	BOVIN|Ensembl=ENSBTAG00000002835|UniProtKB=Q1JQA2	Mothers against decapentaplegic homolog 1	ISS	9395284	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P05913	Enkephalin release	P05974	G-Protein (i)	MACMU|Ensembl=ENSMMUG00000010392|UniProtKB=F7ASR8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DROME|FlyBase=FBgn0003093|UniProtKB=P13678	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00021	FGF signaling pathway	P00642	MEK1-2	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IGI	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00049	Parkinson disease	P01236	Casein kinase II	CAEBR|Gene=CBG12820|UniProtKB=A8XFP5	Protein CBR-KIN-3	ISS	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01161	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P05916	Opioid prodynorphin pathway	P05999	provasopressin	MOUSE|MGI=MGI=97453|UniProtKB=P35454	Oxytocin-neurophysin 1	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DEIRA|EnsemblGenome=DR_0035|UniProtKB=Q9RYB5	Adenylosuccinate synthetase	IEP	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00057	Wnt signaling pathway	P01437	TCF	HUMAN|HGNC=11640|UniProtKB=Q9HCS4	Transcription factor 7-like 1	IDA	11266476	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00021	FGF signaling pathway	P00647	SHP2	CANLF|Ensembl=ENSCAFG00000008894|UniProtKB=F1Q3J6	Tyrosine-protein phosphatase non-receptor type	ISS	14525967	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00029	Huntington disease	P00807	Actin	XENTR|GeneID=394982|UniProtKB=P20399	Actin, alpha cardiac muscle 2	ISS	10974003	PubMed	PTHR11937:SF263	ACTIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	BACSU|EnsemblGenome=BSU12910|UniProtKB=Q00777	Pyrroline-5-carboxylate reductase 3	ISS			PTHR11645:SF0	PYRROLINE-5-CARBOXYLATE REDUCTASE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P02780	Thiamin metabolism	P03184	Thiamine triphosphatase	BOVIN|Ensembl=ENSBTAG00000007097|UniProtKB=Q8MKF1	Thiamine-triphosphatase	IDA	11827967	PubMed	PTHR14586:SF1	THIAMINE-TRIPHOSPHATASE
P00013	Cell cycle	P00483	Cyclin E	HUMAN|HGNC=1589|UniProtKB=P24864	G1/S-specific cyclin-E1	IPI	12628165	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00021	FGF signaling pathway	P00627	ERK1-2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00049	Parkinson disease	P01237	Complex I	ECOLI|EcoGene=EG12086|UniProtKB=P0AFD1	NADH-quinone oxidoreductase subunit E	ISS	3100899	PubMed	PTHR10371:SF3	NADH DEHYDROGENASE  UBIQUINONE  FLAVOPROTEIN 2, MITOCHONDRIAL
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	IC	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02728	Arginine biosynthesis	P02841	argininosuccinate lyase	METJA|EnsemblGenome=MJ_0791|UniProtKB=Q58201	Argininosuccinate lyase	ISS			PTHR43814:SF1	ARGININOSUCCINATE LYASE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	IGI	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	DANRE|ZFIN=ZDB-GENE-090312-91|UniProtKB=F1QR92	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF82	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-6
P00012	Cadherin signaling pathway	P00472	Tyrosine phosphatases	PANTR|Ensembl=ENSPTRG00000023575|UniProtKB=H2R283	Tyrosine-protein phosphatase non-receptor type	ISS			PTHR19134:SF239	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	MOUSE|MGI=MGI=88296|UniProtKB=O55017	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	14624853	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	3045562	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00005	Angiogenesis	P00238	Ras	DICDI|dictyBase=DDB_G0283537|UniProtKB=P32254	Ras-like protein rasS	ISS			PTHR24070:SF380	RAS-LIKE PROTEIN RASS
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=12789|UniProtKB=Q93098	Protein Wnt-8b	IDA	8717036	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P02781	Threonine biosynthesis	P03191	Homoserine kinase	STRCO|EnsemblGenome=CAC33920|UniProtKB=Q9ADB2	Homoserine kinase	ISS			PTHR20861:SF1	HOMOSERINE KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TRIVA|Gene=TVAG_512800|UniProtKB=A2HNG1	Actin (Fragment)	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00557	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00030	Hypoxia response via HIF activation	P00814	P300	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00009	Axon guidance mediated by netrin	P00366	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P06959	CCKR signaling map	P07168	p66 SHC1	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	RCA	11607835	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00021	FGF signaling pathway	P00637	MKK4,7	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MONDO|Ensembl=ENSMODG00000013970|UniProtKB=F6R6X5	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02785	Valine biosynthesis	P03215	Branched chain amino acid aminotransferase	CAEBR|Gene=CBG00050|UniProtKB=A8WM75	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF44	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P00024	Glycolysis	P00675	Pyruvate kinase	PANTR|Ensembl=ENSPTRG00000001421|UniProtKB=H2RBP4	Pyruvate kinase	RCA			PTHR11817:SF31	PYRUVATE KINASE PKLR
P00036	Interleukin signaling pathway	P00973	PKB	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	YEAST|SGD=S000005854|UniProtKB=P33328	Synaptobrevin homolog 2	IC			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00012	Cadherin signaling pathway	P00470	F-actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g242065|UniProtKB=A7S0V7	Predicted protein	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95810|UniProtKB=Q9Z2W9	Glutamate receptor 3	ISS	12941441	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	HUMAN|HGNC=9871|UniProtKB=P20936	Ras GTPase-activating protein 1	TAS	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P06212	DPP-SCW signaling pathway	P06265	MED	DROME|FlyBase=FBgn0011655|UniProtKB=O62609	Mothers against decapentaplegic homolog	IEA	9395284	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	XENTR|Xenbase=XB-GENE-969601|UniProtKB=Q28H40	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00045	Notch signaling pathway	P01113	Pen-2	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	9332390	PubMed	PTHR10202:SF13	PRESENILIN-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IDA	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00020	FAS signaling pathway	P00615	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00010	B cell activation	P00392	I kappa B	MOUSE|MGI=MGI=104741|UniProtKB=Q9Z1E3	NF-kappa-B inhibitor alpha	ISS	10869418	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P04393	Ras Pathway	P04542	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00060	Ubiquitin proteasome pathway	P01491	E2	TAKRU|Ensembl=ENSTRUG00000015781|UniProtKB=H2UTP9	Uncharacterized protein	ISS			PTHR24067:SF88	UBE2G1 PROTEIN
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=98962|UniProtKB=P28047	Protein Wnt-7b	IDA	11266476	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00018	EGF receptor signaling pathway	P00557	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	ISS	96320556	PubMed	PTHR10048:SF14	PI-3 KINASE
P00057	Wnt signaling pathway	P01438	PP2A	XENTR|Xenbase=XB-GENE-484003|UniProtKB=Q6P365	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PANTR|Ensembl=ENSPTRG00000008770|UniProtKB=H2QC99	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF385	MYOSIN-2
P00054	Toll receptor signaling pathway	P01375	JNK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	ISS	10514528	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00006	Apoptosis signaling pathway	P00321	HSP70	THAPS|Gene=Thaps27656|UniProtKB=B8BWB9	Heat shock protein/chaperone	ISS	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	HUMAN|HGNC=234|UniProtKB=O60266	Adenylate cyclase type 3	IGI	2491850	PubMed	PTHR11920:SF291	ADENYLATE CYCLASE TYPE 3
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	8170357	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	HUMAN|HGNC=4600|UniProtKB=O00222	Metabotropic glutamate receptor 8	IC	9407094	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00012	Cadherin signaling pathway	P00477	GSK3beta	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	MOUSE|MGI=MGI=1921575|UniProtKB=Q6IRU5	Clathrin light chain B	ISS	11889126	PubMed	PTHR10639:SF2	CLATHRIN LIGHT CHAIN B
P00019	Endothelin signaling pathway	P00572	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05734	Synaptic vesicle trafficking	P05779	Synaptobrevin	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IDA	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00018	EGF receptor signaling pathway	P00562	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IGI	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00059	p53 pathway	P04633	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00020	FAS signaling pathway	P00614	ASK1	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS			PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04393	Ras Pathway	P04574	PLD	MOUSE|MGI=MGI=892877|UniProtKB=P97813	Phospholipase D2	IDA	15030398	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00644	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00010	B cell activation	P00384	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ORYSJ|EnsemblGenome=OS10G0510000|UniProtKB=A3C6D7	Actin-2	IC	11889126	PubMed	PTHR11937:SF252	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00029	Huntington disease	P00807	Actin	MOUSE|MGI=MGI=87909|UniProtKB=P62737	Actin, aortic smooth muscle	IDA	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	ARATH|TAIR=AT3G04940|UniProtKB=Q9S6Z7	Bifunctional L-3-cyanoalanine synthase/cysteine synthase D1	ISS			PTHR10314:SF97	BIFUNCTIONAL L-3-CYANOALANINE SYNTHASE/CYSTEINE SYNTHASE D1-RELATED
P05731	GABA-B receptor II signaling	P05760	AC	MACMU|Ensembl=ENSMMUG00000006253|UniProtKB=F7H582	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00006	Apoptosis signaling pathway	P00274	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00009	Axon guidance mediated by netrin	P00359	NFAT	HUMAN|HGNC=7778|UniProtKB=Q14934	Nuclear factor of activated T-cells, cytoplasmic 4	IDA	9462517	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P05918	p38 MAPK pathway	P05919	MAPKAP-K3	MACMU|Ensembl=ENSMMUG00000010495|UniProtKB=F7BFL2	MAP kinase-activated protein kinase 3	ISS	11157753	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P05913	Enkephalin release	P05971	CREB	RAT|RGD=620218|UniProtKB=P15337	Cyclic AMP-responsive element-binding protein 1	ISS	1354612	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	IC	8170357	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	CANLF|Ensembl=ENSCAFG00000002067|UniProtKB=F1PUW7	Uncharacterized protein	ISS	96032356	PubMed	PTHR11958:SF69	EXCITATORY AMINO ACID TRANSPORTER 3
P00049	Parkinson disease	P01229	Pael-R	HUMAN|HGNC=14923|UniProtKB=O60883	Prosaposin receptor GPR37L1	IDA			PTHR24243:SF33	PROSAPOSIN RECEPTOR GPR37L1
P04397	p53 pathway by glucose deprivation	G04706	TSC2	RAT|RGD=3908|UniProtKB=P49816	Tuberin	ISS	12150915	PubMed	PTHR10063:SF0	TUBERIN
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12932731	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00188	Ets	BOVIN|Ensembl=ENSBTAG00000002341|UniProtKB=A5PJG9	ETS1 protein	ISS	15699632	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00057	Wnt signaling pathway	P01463	Kremen	CANLF|Ensembl=ENSCAFG00000011994|UniProtKB=F1PCF1	Uncharacterized protein	ISS			PTHR24269:SF13	KREMEN PROTEIN 1
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	CANLF|Ensembl=ENSCAFG00000006453|UniProtKB=F6X958	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01311	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IDA	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00587	Raf-1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00203	Erk	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P02742	Tetrahydrofolate biosynthesis	P02951	GTP cyclohydrolase	MYCTU|EnsemblGenome=Rv3609c|UniProtKB=P9WN57	GTP cyclohydrolase 1	ISS			PTHR11109:SF0	GTP CYCLOHYDROLASE 1
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	91072385	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MACMU|Ensembl=ENSMMUG00000015240|UniProtKB=F6VUY3	Uncharacterized protein	ISS			PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	96009592	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04393	Ras Pathway	P04552	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00056	VEGF signaling pathway	P01414	PLC-gamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	BOVIN|Ensembl=ENSBTAG00000035697|UniProtKB=Q28024	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00049	Parkinson disease	P01230	Src kinase	CHICK|Gene=FYN|UniProtKB=Q05876	Tyrosine-protein kinase Fyn	IDA	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00021	FGF signaling pathway	P00640	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	IGI	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00010	B cell activation	P00388	PLC gamma2	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00049	Parkinson disease	P01238	14-3-3	CAEEL|WormBase=WBGene00003920|UniProtKB=P41932	14-3-3-like protein 1	IDA	21643941	PubMed	PTHR18860:SF21	14-3-3-LIKE PROTEIN 1
P00018	EGF receptor signaling pathway	P00551	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04556	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IDA	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	PANTR|Ensembl=ENSPTRG00000011042|UniProtKB=H2QGF5	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00005	Angiogenesis	P00207	Crk	MOUSE|MGI=MGI=104686|UniProtKB=P47941	Crk-like protein	ISS	8649368	PubMed	PTHR19969:SF9	CRK-LIKE PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=98955|UniProtKB=P17553	Proto-oncogene Wnt-3	TAS	8717036	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MACMU|Ensembl=ENSMMUG00000019399|UniProtKB=F6QFJ6	Frizzled-6	ISS	8717036	PubMed	PTHR11309:SF75	FRIZZLED-6
P00019	Endothelin signaling pathway	P00589	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01324	rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	BOVIN|Ensembl=ENSBTAG00000017639|UniProtKB=F1MZW8	Ribosomal protein S6 kinase	ISS	10480933	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PHYPA|Gene=PHYPADRAFT_225906|UniProtKB=A9TVP1	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	14744463	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00029	Huntington disease	P00778	NMDA receptor	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00018	EGF receptor signaling pathway	P00545	JNK1-3	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IGI	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00053	T cell activation	P01312	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01238	14-3-3	NEUCR|EnsemblGenome=EFNCRG00000002359|UniProtKB=Q7RVK6	14-3-3 family protein 7	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00048	PI3 kinase pathway	P01182	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00006	Apoptosis signaling pathway	P00310	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04557	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00017	DNA replication	P00527	Histones	ORNAN|Ensembl=ENSOANG00000002161|UniProtKB=F7AME5	Histone H3	ISS	20448842	PubMed	PTHR11426:SF163	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01447	Dishevelled	CHICK|Ensembl=ENSGALG00000008414|UniProtKB=F1P5N3	Uncharacterized protein	ISS	10409711	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P00036	Interleukin signaling pathway	P00994	FKHRL1	PANTR|Ensembl=ENSPTRG00000018476|UniProtKB=H2R710	Forkhead box O3	ISS	15031210	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00048	PI3 kinase pathway	P01194	S6K	CHICK|Ensembl=ENSGALG00000005198|UniProtKB=F1P4J0	Ribosomal protein S6 kinase	ISS	15116068	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	RAT|RGD=2746|UniProtKB=P31424	Metabotropic glutamate receptor 5	ISS	9407094	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00585	ECE1-3	RAT|RGD=61806|UniProtKB=Q9JHL3	Endothelin-converting enzyme-like 1	IGI	9931490	PubMed	PTHR11733:SF195	ENDOTHELIN-CONVERTING ENZYME-LIKE 1
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00047	PDGF signaling pathway	P01151	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00238	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	ANOGA|EnsemblGenome=AGAP009734|UniProtKB=Q5TP56	Protein Wnt	TAS	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P02741	Flavin biosynthesis	P02934	Riboflavin kinase	YEAST|SGD=S000002644|UniProtKB=Q03778	Riboflavin kinase	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=11333|UniProtKB=P31391	Somatostatin receptor type 4	IDA	12562507	PubMed	PTHR24229:SF52	SOMATOSTATIN RECEPTOR TYPE 4
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	RCA	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00018	EGF receptor signaling pathway	P00560	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	ANOGA|EnsemblGenome=AGAP004476|UniProtKB=Q7QA16	AGAP004476-PA	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00046	Oxidative stress response	P01132	c-jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	3136397	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	PANTR|Ensembl=ENSPTRG00000000323|UniProtKB=H2PYA3	Uncharacterized protein	ISS	12181435	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02740	De novo pyrimidine ribonucleotides biosythesis	P02927	Dihydrooratate oxidase	ORYSJ|EnsemblGenome=OS04G0676300|UniProtKB=Q7XKC8	Dihydroorotate dehydrogenase (quinone), mitochondrial	ISS			PTHR43517:SF1	DIHYDROOROTATE DEHYDROGENASE  QUINONE , MITOCHONDRIAL
P00057	Wnt signaling pathway	P01472	Histone deacetylase	MOUSE|MGI=MGI=3704479|UniProtKB=D3YYI8	Histone deacetylase	IDA	12665570	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P00012	Cadherin signaling pathway	P00462	Casein kinase II	CAEEL|WormBase=WBGene00002191|UniProtKB=P18334	Casein kinase II subunit alpha	ISS	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00022	General transcription by RNA polymerase I	P00657	TBP	HUMAN|HGNC=11588|UniProtKB=P20226	TATA-box-binding protein	ISS	600075	OMIM	PTHR10126:SF20	TATA-BOX-BINDING PROTEIN
P00029	Huntington disease	P00780	Microtubule	PANTR|Gene=TUBB8|UniProtKB=Q8WP14	Tubulin beta-8 chain	IDA	9454836	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BOVIN|Ensembl=ENSBTAG00000010820|UniProtKB=F1N4C0	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	PANTR|Ensembl=ENSPTRG00000008665|UniProtKB=H2QC24	Dishevelled, dsh homolog 2	ISS	10409711	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P00034	Integrin signalling pathway	P00907	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	CHICK|Gene=PSEN2|UniProtKB=Q90X07	Presenilin-2	TAS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P02746	Heme biosynthesis	P02970	Coproporphyrinogen oxidase (oxygen independent)	ARATH|TAIR=AT5G63290|UniProtKB=Q9FMJ4	At5g63290	ISS			PTHR13932:SF3	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00778	NMDA receptor	RAT|RGD=2740|UniProtKB=Q62645	Glutamate receptor ionotropic, NMDA 2D	IDA	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P04398	p53 pathway feedback loops 2	P04654	Rb	HUMAN|HGNC=9884|UniProtKB=P06400	Retinoblastoma-associated protein	ISS			PTHR13742:SF17	RETINOBLASTOMA-ASSOCIATED PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00548	RKIP	XENTR|Xenbase=XB-GENE-973798|UniProtKB=F6Y4G1	Uncharacterized protein	ISS			PTHR11362:SF28	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CAEEL|WormBase=WBGene00000057|UniProtKB=G5EG72	AcetylCholine Receptor	IC			PTHR18945:SF415	ACETYLCHOLINE RECEPTOR
P00044	Nicotinic acetylcholine receptor signaling pathway	P01093	AChE	BRAFL|Gene=BRAFLDRAFT_116869|UniProtKB=C3ZD75	Carboxylic ester hydrolase	ISS	87080761	PubMed	PTHR11559:SF356	ACETYLCHOLINESTERASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	IC	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Ensembl=ENSPTRG00000013825|UniProtKB=H2RAK4	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00010	B cell activation	P00380	fos	CANLF|Ensembl=ENSCAFG00000017040|UniProtKB=E2QYK5	Uncharacterized protein	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DANRE|ZFIN=ZDB-GENE-040625-35|UniProtKB=Q6IQL9	Novel actin protein	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	PANTR|Ensembl=ENSPTRG00000003957|UniProtKB=H2Q486	Ribosomal protein S6 kinase	ISS	15116068	PubMed	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00907	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00059	p53 pathway	P04630	PP2A	CHICK|Ensembl=ENSGALG00000010273|UniProtKB=P48463	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P06664	Gonadotropin-releasing hormone receptor pathway	P06755	CBP	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	RCA	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04393	Ras Pathway	P04571	Tiam1	MOUSE|MGI=MGI=103306|UniProtKB=Q60610	T-lymphoma invasion and metastasis-inducing protein 1	IDA	11130063	PubMed	PTHR22826:SF88	T-LYMPHOMA INVASION AND METASTASIS-INDUCING PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P06959	CCKR signaling map	P07088	RYR1/2/3	HUMAN|HGNC=10484|UniProtKB=Q92736	Ryanodine receptor 2	RCA	16786171	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00049	Parkinson disease	P01212	p38 MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IDA	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04546	GSK3	CIOIN|Ensembl=ENSCING00000001821|UniProtKB=Q9NL43	Glycogen synthase kinase	ISS	12615961	PubMed	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02762	Pentose phosphate pathway	P03079	Hexokinase	HUMAN|HGNC=4923|UniProtKB=P52789	Hexokinase-2	RCA			PTHR19443:SF4	HEXOKINASE-2
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	MOUSE|MGI=MGI=87912|UniProtKB=P27040	Activin receptor type-2B	TAS	11252892	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P00045	Notch signaling pathway	P01105	TACE	RAT|RGD=620404|UniProtKB=Q9Z1K9	Disintegrin and metalloproteinase domain-containing protein 17	ISS	12834808	PubMed	PTHR11905:SF171	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CAEEL|WormBase=WBGene00004056|UniProtKB=Q8MXI4	Mitogen-activated protein kinase pmk-2	IDA	10514528	PubMed	PTHR24055:SF154	MITOGEN-ACTIVATED PROTEIN KINASE PMK-2
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00034	Integrin signalling pathway	P00916	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IPI	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00021	FGF signaling pathway	P00623	FGF	ORNAN|Ensembl=ENSOANG00000011663|UniProtKB=F6RAU4	Fibroblast growth factor	ISS	97376484	PubMed	PTHR11486:SF77	FIBROBLAST GROWTH FACTOR 13
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00019	Endothelin signaling pathway	P00573	signal peptidase	BOVIN|Ensembl=ENSBTAG00000011239|UniProtKB=P67810	Signal peptidase complex catalytic subunit SEC11A	ISS	2674115	PubMed	PTHR10806:SF8	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11A-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000014674|UniProtKB=P41985	Muscarinic acetylcholine receptor M2	ISS	11166329	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01331	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IDA	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02742	Tetrahydrofolate biosynthesis	P02945	Dihydropteroate synthase	ARATH|TAIR=AT1G69190|UniProtKB=Q1ENB6	Folate synthesis bifunctional protein	ISS			PTHR20941:SF1	FOLIC ACID SYNTHESIS PROTEIN FOL1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01192	p110	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MOUSE|MGI=MGI=1309999|UniProtKB=Q922R0	cAMP-dependent protein kinase catalytic subunit PRKX	IC	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P05916	Opioid prodynorphin pathway	P06002	G-protein	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00030	Hypoxia response via HIF activation	P00814	P300	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P02746	Heme biosynthesis	P02983	Hydroxymethylbilane synthase	SCHPO|PomBase=SPAC24B11.13|UniProtKB=Q09899	Porphobilinogen deaminase	ISS			PTHR11557:SF0	PORPHOBILINOGEN DEAMINASE
P00030	Hypoxia response via HIF activation	P00824	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	TAS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00018	EGF receptor signaling pathway	P00549	EGF	HUMAN|HGNC=11765|UniProtKB=P01135	Protransforming growth factor alpha	IGI	4507461	gi	PTHR10740:SF1	PROTRANSFORMING GROWTH FACTOR ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01192	p110	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04633	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05916	Opioid prodynorphin pathway	P06002	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	BOVIN|Ensembl=ENSBTAG00000000219|UniProtKB=F1MCL3	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01081	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000020569|UniProtKB=F1N7F9	Uncharacterized protein	ISS	21601730	PubMed	PTHR10166:SF6	VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00046	Oxidative stress response	P01138	MKK4	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS	12052864	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000003236|UniProtKB=F7DNS6	Uncharacterized protein	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P04393	Ras Pathway	P04552	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IDA	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00011	Blood coagulation	P00444	FIX	PANTR|Gene=F9|UniProtKB=Q95ND7	Coagulation factor IX	ISS	14270099	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P00029	Huntington disease	P00796	Kainate receptor	RAT|RGD=2734|UniProtKB=Q01812	Glutamate receptor ionotropic, kainate 4	IDA	1648176	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00049	Parkinson disease	P01238	14-3-3	ORNAN|Ensembl=ENSOANG00000007305|UniProtKB=F6XW91	Uncharacterized protein	ISS	92283271	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	HUMAN|HGNC=6270|UniProtKB=Q92806	G protein-activated inward rectifier potassium channel 3	IDA	2433589	PubMed	PTHR11767:SF17	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	DANRE|ZFIN=ZDB-GENE-040718-144|UniProtKB=Q6DHE8	Rho-related GTP-binding protein RhoA-D	ISS	10556059	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05939	GRK6	MACMU|Ensembl=ENSMMUG00000019817|UniProtKB=F7FY63	Protein-serine/threonine kinase	ISS	12032308	PubMed	PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	IDA	91056091	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00036	Interleukin signaling pathway	P00983	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04634	Cdc2	DANRE|ZFIN=ZDB-GENE-010320-1|UniProtKB=Q7T3L7	Cell division control protein 2	ISS			PTHR24056:SF334	CYCLIN-DEPENDENT KINASE 1
P00001	Adrenaline and noradrenaline biosynthesis	P00065	DAT	HUMAN|HGNC=11049|UniProtKB=Q01959	Sodium-dependent dopamine transporter	ISS	15135042	PubMed	PTHR11616:SF38	SODIUM-DEPENDENT DOPAMINE TRANSPORTER
P00029	Huntington disease	P00807	Actin	DROME|FlyBase=FBgn0000047|UniProtKB=P83967	Actin, indirect flight muscle	IDA	11889126	PubMed	PTHR11937:SF368	ACTIN, INDIRECT FLIGHT MUSCLE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00029	Huntington disease	P00790	beta-Tubulin	PRIPA|Gene=PPA21758|UniProtKB=H3FHL1	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF89	TUBULIN BETA-4 CHAIN
P00059	p53 pathway	P04609	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	96009592	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00053	T cell activation	P01331	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P02752	Mannose metabolism	P03018	Mannose 1-P guanylyl transferase	CAEBR|Gene=CBG12186|UniProtKB=A8XF15	Protein CBG12186	ISS	17509979	gi	PTHR22572:SF104	MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05994	G-protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Ensembl=ENSPTRG00000018449|UniProtKB=H2QTG5	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00014	Cholesterol biosynthesis	P00496	Diphosphomevalonate decarboxylase	PANTR|Ensembl=ENSPTRG00000008459|UniProtKB=H2QBQ1	Mevalonate (Diphospho) decarboxylase	ISS	4505289	gi	PTHR10977:SF3	DIPHOSPHOMEVALONATE DECARBOXYLASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00887	IRS 1-4	HUMAN|HGNC=6125|UniProtKB=P35568	Insulin receptor substrate 1	TAS	1311924	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00012	Cadherin signaling pathway	P00471	Cadherin	DANRE|ZFIN=ZDB-GENE-030910-3|UniProtKB=F1RD80	Uncharacterized protein	IDA	8120095	PubMed	PTHR44603:SF2	CADHERIN-17
P00021	FGF signaling pathway	P00629	PP2A	BOVIN|Ensembl=ENSBTAG00000000754|UniProtKB=A2VDZ0	Protein phosphatase 2, regulatory subunit B', alpha isoform	ISS	12110603	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P02749	Leucine biosynthesis	P03000	Branched chain amino acid aminotransferase	PANTR|Ensembl=ENSPTRG00000011258|UniProtKB=H2QGS7	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF39	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, MITOCHONDRIAL
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	PANTR|Ensembl=ENSPTRG00000001609|UniProtKB=H2R8G6	Regulator of G-protein signaling 5	ISS	8756726	PubMed	PTHR10845:SF42	REGULATOR OF G-PROTEIN SIGNALING 5
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	TAS	10395542	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P06959	CCKR signaling map	P07019	RHOA-GDP	HUMAN|HGNC=667|UniProtKB=P61586	Transforming protein RhoA	RCA	18565785	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	ORNAN|Ensembl=ENSOANG00000013097|UniProtKB=F6UVN1	Uncharacterized protein	ISS	600075	OMIM	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	8270251	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CHICK|Ensembl=ENSGALG00000008591|UniProtKB=E1BZF6	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P02736	Coenzyme A biosynthesis	P02882	Pantothenate cysteine ligase	METAC|EnsemblGenome=MA_1280|UniProtKB=Q8TRA0	Pantothenate metabolism flavoprotein	ISS			PTHR14359:SF6	PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE
P00060	Ubiquitin proteasome pathway	P01491	E2	ARATH|TAIR=AT5G53300|UniProtKB=P35133	Ubiquitin-conjugating enzyme E2 10	ISS			PTHR24068:SF65	UBIQUITIN-CONJUGATING ENZYME E2 10-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000012539|UniProtKB=H2RC03	Uncharacterized protein	ISS			PTHR11824:SF7	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	MONDO|Ensembl=ENSMODG00000013354|UniProtKB=F7DTY4	Inosine-5'-monophosphate dehydrogenase	ISS			PTHR11911:SF121	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2
P00021	FGF signaling pathway	P00624	14-3-3	ORNAN|Ensembl=ENSOANG00000003572|UniProtKB=F7DGH9	Uncharacterized protein	ISS	6756037	gi	PTHR18860:SF16	14-3-3 PROTEIN ETA
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00629	PP2A	RAT|RGD=619798|UniProtKB=Q8VI02	Serine/threonine-protein phosphatase 4 regulatory subunit 1	ISS			PTHR10648:SF8	SERINE/THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000006289|UniProtKB=H2Q875	Uncharacterized protein	ISS	12562507	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P00029	Huntington disease	P00790	beta-Tubulin	DROME|FlyBase=FBgn0003889|UniProtKB=P61857	Tubulin beta-2 chain	TAS	9454836	PubMed	PTHR11588:SF155	TUBULIN BETA-2 CHAIN
P00018	EGF receptor signaling pathway	P00565	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IGI	10395542	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00057	Wnt signaling pathway	P01457	GBeta	DAPPU|EnsemblGenome=DAPPUDRAFT_206575|UniProtKB=E9FUX0	Guanine nucleotide binding protein, beta subunit	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P02743	Formyltetrahydroformate biosynthesis	P02953	Cobalamin dependent homocysteine transmethylase	BACSU|EnsemblGenome=BSU11010|UniProtKB=O06745	Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase	ISS			PTHR21091:SF166	SUBFAMILY NOT NAMED
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00005	Angiogenesis	P00190	RasGAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	ISS	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	BOVIN|Ensembl=ENSBTAG00000017514|UniProtKB=Q2KI22	G1/S-specific cyclin-D1	ISS	12356903	PubMed	PTHR10177:SF67	G1/S-SPECIFIC CYCLIN-D1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	ANOGA|EnsemblGenome=AGAP001506|UniProtKB=Q7PXP3	AGAP001506-PA	IC			PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00029	Huntington disease	P00805	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	11204774	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MOUSE|MGI=MGI=95815|UniProtKB=P39087	Glutamate receptor ionotropic, kainate 2	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00045	Notch signaling pathway	P01099	Notch	MACMU|Ensembl=ENSMMUG00000013637|UniProtKB=F7GL52	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-1712|UniProtKB=Q6PBY0	Guanine nucleotide binding protein (G protein), beta 5	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00049	Parkinson disease	P01208	Hsp70	ARATH|TAIR=AT5G09590|UniProtKB=Q9LDZ0	Heat shock 70 kDa protein 10, mitochondrial	IDA	12150907	PubMed	PTHR19375:SF319	HEAT SHOCK 70 KDA PROTEIN 10, MITOCHONDRIAL
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01084	CHT1	CANLF|Ensembl=ENSCAFG00000019243|UniProtKB=F1PZI9	Transporter	ISS			PTHR11616:SF96	SODIUM- AND CHLORIDE-DEPENDENT CREATINE TRANSPORTER 1
P00049	Parkinson disease	P01242	Casein kinase I	DROME|FlyBase=FBgn0002413|UniProtKB=O76324	Discs overgrown protein kinase	IDA	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00034	Integrin signalling pathway	P00912	Arp2/3	HUMAN|HGNC=703|UniProtKB=Q92747	Actin-related protein 2/3 complex subunit 1A	IPI	12473693	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00057	Wnt signaling pathway	P01438	PP2A	HUMAN|HGNC=9309|UniProtKB=Q15172	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform	IDA	12110603	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01179	PKB	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	DAPPU|EnsemblGenome=DAPPUDRAFT_206575|UniProtKB=E9FUX0	Guanine nucleotide binding protein, beta subunit	ISS	9740024	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00049	Parkinson disease	P01230	Src kinase	HUMAN|HGNC=11283|UniProtKB=P12931	Proto-oncogene tyrosine-protein kinase Src	IDA	11078745	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00006	Apoptosis signaling pathway	P00310	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IDA	1171954	gi	PTHR10048:SF14	PI-3 KINASE
P04376	5HT4 type receptor mediated signaling pathway	P04427	5HT4 Receptor	HUMAN|HGNC=5299|UniProtKB=Q13639	5-hydroxytryptamine receptor 4	ISS	12441358	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P00049	Parkinson disease	P01242	Casein kinase I	ARATH|TAIR=AT3G13670|UniProtKB=Q9LID3	Casein kinase-like protein	IDA	10617630	PubMed	PTHR11909:SF289	CASEIN KINASE-LIKE PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	DANRE|ZFIN=ZDB-GENE-991119-4|UniProtKB=Q9W6T7	Presenilin-1	IDA	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00253	Axin	PANTR|Ensembl=ENSPTRG00000007537|UniProtKB=H2R1H5	Uncharacterized protein	ISS	12356903	PubMed	PTHR10845:SF11	AXIN-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00005	Angiogenesis	P00206	Wnt	HUMAN|HGNC=12786|UniProtKB=O00755	Protein Wnt-7a	IEP	11266476	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00048	PI3 kinase pathway	P01188	Gbetagamma	CAEEL|WormBase=WBGene00001679|UniProtKB=P17343	Guanine nucleotide-binding protein subunit beta-1	IC	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MACMU|Ensembl=ENSMMUG00000010266|UniProtKB=F6PV18	Uncharacterized protein	ISS	6309844	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00030	Hypoxia response via HIF activation	P00819	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MACMU|Ensembl=ENSMMUG00000014246|UniProtKB=F7C4D3	Uncharacterized protein	ISS	9395284	PubMed	PTHR11848:SF133	INHIBIN BETA A CHAIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	SCHMA|EnsemblGenome=Smp_202970|UniProtKB=G4VLN1	Putative uncharacterized protein Smp_202970	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	EMENI|EnsemblGenome=CADANIAG00006296|UniProtKB=Q5ASG1	Putative synaptobrevin homologue SNC1/2 (Eurofung)	ISS			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000022175|UniProtKB=F6XHY0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00546	GAP	DROME|FlyBase=FBgn0003969|UniProtKB=Q8IR23	GH13542p	ISS	17737349	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00010	B cell activation	P00372	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	8479536	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	TAS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12912997	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	IC	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01453	Ebi	BOVIN|Ensembl=ENSBTAG00000018112|UniProtKB=B7TCI5	Transducin beta-like 1	ISS	11389839	PubMed	PTHR22846:SF2	F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN TBL1X
P00023	General transcription regulation	P00662	TFIIA complex	RAT|RGD=69246|UniProtKB=O08949	Transcription initiation factor IIA subunit 1	ISS	600519	OMIM	PTHR12694:SF7	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MOUSE|MGI=MGI=109349|UniProtKB=P16951	Cyclic AMP-dependent transcription factor ATF-2	TAS	11390664	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00005	Angiogenesis	P00229	SPK	RAT|RGD=1307757|UniProtKB=Q6AYB2	Protein Sphk2	ISS			PTHR12358:SF40	SPHINGOSINE KINASE 2
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05916	Opioid prodynorphin pathway	P06002	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00038	JAK/STAT signaling pathway	P01027	STAT	CANLF|Ensembl=ENSCAFG00000015346|UniProtKB=E2RE22	Signal transducer and activator of transcription	ISS	10835485	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	BOVIN|Ensembl=ENSBTAG00000021538|UniProtKB=F1MQ65	Uncharacterized protein	ISS			PTHR13140:SF341	UNCONVENTIONAL MYOSIN-IE
P04397	p53 pathway by glucose deprivation	P04641	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01215	Syntaxin	HUMAN|HGNC=11430|UniProtKB=Q86Y82	Syntaxin-12	IPI	10321247	PubMed	PTHR19957:SF88	SYNTAXIN-12
P00047	PDGF signaling pathway	P01143	ERK	ORYSJ|Gene=Os01g0665200|UniProtKB=Q5SN53	Mitogen-activated protein kinase 8	ISS	10851062	PubMed	PTHR24055:SF219	SUBFAMILY NOT NAMED
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00036	Interleukin signaling pathway	P00986	eNOS	PANTR|Ensembl=ENSPTRG00000019868|UniProtKB=H2QVM2	Nitric oxide synthase	ISS	93055452	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01179	PKB	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	SCHPO|PomBase=SPAC6G9.11|UniProtKB=Q92356	Synaptobrevin homolog 1	IC			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04395	Vasopressin synthesis	P04593	Glycopeptide	HUMAN|HGNC=8528|UniProtKB=P01178	Oxytocin-neurophysin 1	IC	3768139	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P02733	Carnitine metabolism	P02866	Carnitine dehydratase	SULSO|EnsemblGenome=SSO3144|UniProtKB=Q97U79	Carnitine dehydratase, putative	ISS			PTHR43949:SF6	SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	IC	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00020	FAS signaling pathway	P00615	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00056	VEGF signaling pathway	P01425	PKC	CAEEL|WormBase=WBGene00012019|UniProtKB=O45818	Serine/threonine-protein kinase dkf-2	ISS			PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P04384	Gamma-aminobutyric acid synthesis	P04482	Glutamate decarboxylase	HUMAN|HGNC=4092|UniProtKB=Q99259	Glutamate decarboxylase 1	ISS	2247446	PubMed	PTHR11999:SF57	GLUTAMATE DECARBOXYLASE 1
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00036	Interleukin signaling pathway	P00976	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00029	Huntington disease	P00778	NMDA receptor	MOUSE|MGI=MGI=95822|UniProtKB=Q01098	Glutamate receptor ionotropic, NMDA 2C	IDA	14698601	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MACMU|Ensembl=ENSMMUG00000008877|UniProtKB=F7DTM8	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00001	Adrenaline and noradrenaline biosynthesis	P00067	MAO	CANLF|Gene=MAOB|UniProtKB=Q7YRB7	Amine oxidase [flavin-containing] B	ISS	90344230	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00635	FRS2	MOUSE|MGI=MGI=1100860|UniProtKB=Q8C180	Fibroblast growth factor receptor substrate 2	ISS	10464310	PubMed	PTHR21258:SF40	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2
P00021	FGF signaling pathway	P00629	PP2A	PANTR|Ensembl=ENSPTRG00000006426|UniProtKB=H2Q8F8	Protein phosphatase 2, regulatory subunit B', epsilon isoform	ISS	10092233	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00036	Interleukin signaling pathway	P00975	RasGAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	14707121	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	RAT|RGD=2520|UniProtKB=P61169	D(2) dopamine receptor	ISS	2039532	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00020	FAS signaling pathway	P00593	Caspase9	PANTR|Ensembl=ENSPTRG00000000200|UniProtKB=H2PY35	Caspase	ISS	8663294	PubMed	PTHR10454:SF157	CASPASE-9
P00047	PDGF signaling pathway	P01151	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00182	p38MAPK	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00052	TGF-beta signaling pathway	P01275	P38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00045	Notch signaling pathway	P01116	Delta	MACMU|Ensembl=ENSMMUG00000014541|UniProtKB=F7G756	Delta-like protein	ISS	11798067	PubMed	PTHR24044:SF320	DELTA-LIKE PROTEIN 4
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00303	c-Jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	MOUSE|MGI=MGI=88275|UniProtKB=Q61301	Catenin alpha-2	TAS	9362521	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	IC	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00010	B cell activation	P00384	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P02743	Formyltetrahydroformate biosynthesis	P02956	Formyl tetrahydrofolate deformylase	PSEAE|EnsemblGenome=PA4314|UniProtKB=Q9HW87	Formyltetrahydrofolate deformylase	ISS			PTHR42706:SF1	FORMYLTETRAHYDROFOLATE DEFORMYLASE 1, MITOCHONDRIAL-RELATED
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MACMU|Ensembl=ENSMMUG00000020134|UniProtKB=F6U055	Uncharacterized protein	ISS	9118222	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	DROME|FlyBase=FBgn0019947|UniProtKB=O02194	Presenilin homolog	IDA	12369105	PubMed	PTHR10202:SF13	PRESENILIN-2
P00029	Huntington disease	P00774	Dynein complex	DROME|FlyBase=FBgn0034106|UniProtKB=A1ZAD3	CG9068	IPI	9454836	PubMed	PTHR22878:SF43	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04546	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	IDA	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00049	Parkinson disease	P01211	ERK	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	IDA	10514528	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00021	FGF signaling pathway	P00624	14-3-3	MACMU|Ensembl=ENSMMUG00000004125|UniProtKB=F6XLR8	14-3-3 protein gamma	ISS	10407019	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00029	Huntington disease	P00807	Actin	ORYSJ|EnsemblGenome=OS11G0163100|UniProtKB=Q67G20	Actin	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04393	Ras Pathway	P04570	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	PANTR|Ensembl=ENSPTRG00000002741|UniProtKB=H2Q292	Uncharacterized protein	ISS	12441358	PubMed	PTHR24247:SF116	5-HYDROXYTRYPTAMINE RECEPTOR 7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	PANTR|Ensembl=ENSPTRG00000008766|UniProtKB=H2QC97	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF504	MYOSIN-13
P00045	Notch signaling pathway	P01111	LNXp80	PANTR|Ensembl=ENSPTRG00000005733|UniProtKB=H2Q7C2	Ligand of numb-protein X 2	ISS			PTHR19964:SF33	LIGAND OF NUMB PROTEIN X 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	TAS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00012	Cadherin signaling pathway	P00463	betacatenin	BOVIN|Ensembl=ENSBTAG00000016420|UniProtKB=Q0VCX4	Catenin beta-1	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	BRAFL|Gene=BRAFLDRAFT_60807|UniProtKB=C3Y2F5	Putative uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	CAEEL|WormBase=WBGene00009119|UniProtKB=Q93576	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00029	Huntington disease	P00784	MAPKK7	MOUSE|MGI=MGI=1346871|UniProtKB=Q8CE90	Dual specificity mitogen-activated protein kinase kinase 7	RCA	15039780	PubMed	PTHR24361:SF387	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7
P04376	5HT4 type receptor mediated signaling pathway	P04426	K+ channel	RAT|RGD=61997|UniProtKB=O54912	Potassium channel subfamily K member 3	ISS	15282272	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00056	VEGF signaling pathway	P01417	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01159	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05915	Opioid proenkephalin pathway	P05990	K+ channel	BOVIN|Ensembl=ENSBTAG00000018193|UniProtKB=E1BHX8	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	ARATH|TAIR=AT3G08510|UniProtKB=Q39033	Phosphoinositide phospholipase C 2	ISS			PTHR10336:SF92	PHOSPHOINOSITIDE PHOSPHOLIPASE C 2-RELATED
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00021	FGF signaling pathway	P00629	PP2A	TRYB2|Gene=Tb11.01.8740|UniProtKB=Q380Z0	Serine/threonine-protein phosphatase	ISS			PTHR11668:SF22	SERINE/THREONINE-PROTEIN PHOSPHATASE 4 CATALYTIC SUBUNIT
P04376	5HT4 type receptor mediated signaling pathway	P04426	K+ channel	BOVIN|Ensembl=ENSBTAG00000018193|UniProtKB=E1BHX8	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	CHICK|Ensembl=ENSGALG00000002550|UniProtKB=O57340	Thyrotropin subunit beta	ISS	5101174	PubMed	PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	IDA	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00005	Angiogenesis	P00215	Nck	MOUSE|MGI=MGI=109601|UniProtKB=Q99M51	Cytoplasmic protein NCK1	ISS	11689432	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P00049	Parkinson disease	P01230	Src kinase	BOVIN|Ensembl=ENSBTAG00000011851|UniProtKB=A0JNB0	Tyrosine-protein kinase Fyn	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P05913	Enkephalin release	P05974	G-Protein (i)	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00053	T cell activation	P01322	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	TAKRU|Ensembl=ENSTRUG00000006464|UniProtKB=H2STT5	Uncharacterized protein	ISS	8576107	PubMed	PTHR24070:SF382	RAS-RELATED PROTEIN RAP-1B
P00048	PI3 kinase pathway	P01188	Gbetagamma	DAPPU|EnsemblGenome=DAPPUDRAFT_206575|UniProtKB=E9FUX0	Guanine nucleotide binding protein, beta subunit	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P02771	Pyrimidine Metabolism	P03124	Methylmalonate Semialdehyde Dehydrogenase	DROME|FlyBase=FBgn0023537|UniProtKB=Q7KW39	Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	TAS	7431479	gi	PTHR43866:SF3	METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE  ACYLATING , MITOCHONDRIAL
P00021	FGF signaling pathway	P00643	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05915	Opioid proenkephalin pathway	P05990	K+ channel	RAT|RGD=61997|UniProtKB=O54912	Potassium channel subfamily K member 3	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	CHICK|Ensembl=ENSGALG00000028612|UniProtKB=F1P3X1	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF728	MYOSIN HEAVY CHAIN, SKELETAL MUSCLE, ADULT
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01070	K+ channel	RAT|RGD=621504|UniProtKB=O88943	Potassium voltage-gated channel subfamily KQT member 2	ISS	12223552	PubMed	PTHR11537:SF6	POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 2
P00048	PI3 kinase pathway	P01181	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CAEBR|Gene=CBG02401|UniProtKB=A8WUE7	Protein CBR-NMR-1	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00012	Cadherin signaling pathway	P00463	betacatenin	RAT|RGD=70487|UniProtKB=Q9WU82	Catenin beta-1	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_59367|UniProtKB=E9H7Z0	Guanine nucleotide-binding protein G(O) subunit alpha 1	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MONDO|Ensembl=ENSMODG00000012546|UniProtKB=F6PM16	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00036	Interleukin signaling pathway	P00990	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	HUMAN|HGNC=19260|UniProtKB=Q9NPC1	Leukotriene B4 receptor 2	ISS	10934230	PubMed	PTHR24230:SF8	LEUKOTRIENE B4 RECEPTOR 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347740|UniProtKB=E9FXV8	Cytoplasmatic actin	ISS	10974003	PubMed	PTHR11937:SF277	SUBFAMILY NOT NAMED
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	MACMU|Ensembl=ENSMMUG00000001387|UniProtKB=F7D0B4	Uncharacterized protein	ISS	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DANRE|ZFIN=ZDB-GENE-041210-195|UniProtKB=F1R506	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	TAS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00034	Integrin signalling pathway	P00906	Rap1	CHICK|Ensembl=ENSGALG00000028967|UniProtKB=Q6IMM1	DnaJ homolog subfamily C member 27	ISS			PTHR24073:SF269	DNAJ HOMOLOG SUBFAMILY C MEMBER 27
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	RCA	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	8920915	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	PANTR|Ensembl=ENSPTRG00000014922|UniProtKB=H2QML4	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00049	Parkinson disease	P01208	Hsp70	HUMAN|HGNC=5235|UniProtKB=P54652	Heat shock-related 70 kDa protein 2	IDA	12150907	PubMed	PTHR19375:SF216	HEAT SHOCK-RELATED 70 KDA PROTEIN 2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TRIVA|Gene=TVAG_054030|UniProtKB=A2G1K5	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	HUMAN|HGNC=7882|UniProtKB=Q04721	Neurogenic locus notch homolog protein 2	IDA	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P02728	Arginine biosynthesis	P02846	Ornithine carbamoyl transferase	HALSA|EnsemblGenome=VNG_6315G|UniProtKB=Q48296	Ornithine carbamoyltransferase, catabolic	ISS			PTHR11405:SF1	ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000008826|UniProtKB=F6XUU0	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00562	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05918	p38 MAPK pathway	P06034	MKK4	MOUSE|MGI=MGI=1346869|UniProtKB=P47809	Dual specificity mitogen-activated protein kinase kinase 4	RCA	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P02738	De novo purine biosynthesis	P02908	Phosphoribosylamine glycine ligase	PSEAE|EnsemblGenome=PA4855|UniProtKB=Q9HUV8	Phosphoribosylamine--glycine ligase	ISS			PTHR43472:SF1	PHOSPHORIBOSYLAMINE--GLYCINE LIGASE
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	FUSNN|EnsemblGenome=FN0452|UniProtKB=Q8RG65	Glutamine--fructose-6-phosphate aminotransferase [isomerizing]	ISS			PTHR10937:SF0	GH12731P-RELATED
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=5287|UniProtKB=P28222	5-hydroxytryptamine receptor 1B	IDA	11454663	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	IC	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04393	Ras Pathway	P04542	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00017	DNA replication	P00536	DNA Topisomerase	ARATH|TAIR=AT5G55300|UniProtKB=P30181	DNA topoisomerase 1	ISS			PTHR10290:SF3	DNA TOPOISOMERASE 1
P04398	p53 pathway feedback loops 2	P04658	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04393	Ras Pathway	P04548	ATF2	MONDO|Ensembl=ENSMODG00000009514|UniProtKB=F7EVK3	Uncharacterized protein	ISS	10664585	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00034	Integrin signalling pathway	P00951	Jnk	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00034	Integrin signalling pathway	P00928	alpha actinin	CAEEL|WormBase=WBGene00000228|UniProtKB=Q23158	AcTiniN	IPI	2116421	PubMed	PTHR43947:SF1	ALPHA-ACTININ, SARCOMERIC
P00034	Integrin signalling pathway	P00951	Jnk	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IDA	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	BOVIN|Ensembl=ENSBTAG00000007517|UniProtKB=F1MUN1	Uncharacterized protein	ISS	22213672	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P00036	Interleukin signaling pathway	P00990	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00025	Hedgehog signaling pathway	P00691	CBP	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	TAS	10644715	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00017	DNA replication	P00527	Histones	BRAFL|Gene=BRAFLDRAFT_125364|UniProtKB=C3XUS0	Histone H3	ISS	12413958	PubMed	PTHR11426:SF110	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01026	KA	CHICK|Ensembl=ENSGALG00000002098|UniProtKB=F1P0L4	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00009	Axon guidance mediated by netrin	P00364	cdc42	HUMAN|HGNC=1736|UniProtKB=P60953	Cell division control protein 42 homolog	ISS	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00036	Interleukin signaling pathway	P00987	SRF	RAT|RGD=1559787|UniProtKB=D3ZHH8	Protein Srf	ISS	8660892	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00056	VEGF signaling pathway	P01425	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00010	B cell activation	P00398	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00521	Profilin	CAEEL|WormBase=WBGene00003991|UniProtKB=Q21193	Profilin-3	ISS			PTHR11604:SF0	PROFILIN
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	TAS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00796	Kainate receptor	MACMU|Ensembl=ENSMMUG00000009679|UniProtKB=F6YBQ8	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00034	Integrin signalling pathway	P00920	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000022175|UniProtKB=F6XHY0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P05731	GABA-B receptor II signaling	P05754	Ggamma	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	TAKRU|Ensembl=ENSTRUG00000016241|UniProtKB=H2UX35	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF305	PROTEIN KINASE C
P00029	Huntington disease	G01535	PIG3	DANRE|ZFIN=ZDB-GENE-030616-178|UniProtKB=Q8JFV8	Synaptic vesicle membrane protein VAT-1 homolog	ISS	12932731	PubMed	PTHR44054:SF1	SYNAPTIC VESICLE MEMBRANE PROTEIN VAT-1 HOMOLOG
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00049	Parkinson disease	P01238	14-3-3	CANLF|Ensembl=ENSCAFG00000003386|UniProtKB=F6Y478	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	RAT|RGD=2735|UniProtKB=Q63273	Glutamate receptor ionotropic, kainate 5	ISS	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00054	Toll receptor signaling pathway	P01346	TLR	PANTR|Ensembl=ENSPTRG00000015986|UniProtKB=B3Y641	Toll-like receptor	ISS			PTHR24365:SF422	TOLL-LIKE RECEPTOR 6
P00029	Huntington disease	P00775	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00047	PDGF signaling pathway	P01164	PDK1/2	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	ISS	15531926	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00034	Integrin signalling pathway	P00907	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01150	PKC	BOVIN|Ensembl=ENSBTAG00000021900|UniProtKB=F1MFK1	Uncharacterized protein	ISS	10644715	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P05918	p38 MAPK pathway	P06019	ATF1	PANTR|Ensembl=ENSPTRG00000004941|UniProtKB=H2Q5X1	Activating transcription factor 1	ISS	11390664	PubMed	PTHR22952:SF258	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-1
P00034	Integrin signalling pathway	P00913	Csk	PANTR|Ensembl=ENSPTRG00000007282|UniProtKB=H2Q9T1	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P06959	CCKR signaling map	G06988	CALCA	HUMAN|HGNC=1437|UniProtKB=P01258	Calcitonin	RCA	20671197	PubMed	PTHR10505:SF14	CALCITONIN
P00059	p53 pathway	P04630	PP2A	MONDO|Ensembl=ENSMODG00000014177|UniProtKB=F6U7A6	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	PSEAE|EnsemblGenome=PA4733|UniProtKB=Q9HV66	Acetyl-coenzyme A synthetase 2	ISS			PTHR24095:SF14	ACETYL-COENZYME A SYNTHETASE 1
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	HUMAN|HGNC=7882|UniProtKB=Q04721	Neurogenic locus notch homolog protein 2	IDA	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	TAS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00053	T cell activation	P01318	PKC-theta	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IGI	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	IDA	10514528	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	ANOGA|EnsemblGenome=AGAP002176|UniProtKB=Q7QK68	AGAP002176-PA	IDA			PTHR42884:SF13	NEUROENDOCRINE CONVERTASE 2
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IGI	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P02729	Ascorbate degradation	P02852	L-xylulose-5-phosphate-3-epimerase	MOUSE|MGI=MGI=1913896|UniProtKB=Q8VEE0	Ribulose-phosphate 3-epimerase	ISS			PTHR11749:SF3	RIBULOSE-PHOSPHATE 3-EPIMERASE
P00056	VEGF signaling pathway	P01414	PLC-gamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	BOVIN|Ensembl=ENSBTAG00000003512|UniProtKB=E1BPX8	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF358	MYOSIN-7B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00797	p53	PANTR|Ensembl=ENSPTRG00000008703|UniProtKB=H2QC53	Cellular tumor antigen p53	ISS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	RAT|RGD=2026|UniProtKB=P68035	Actin, alpha cardiac muscle 1	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00047	PDGF signaling pathway	P01147	Nck	HUMAN|HGNC=7664|UniProtKB=P16333	Cytoplasmic protein NCK1	ISS	11689432	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P02757	O-antigen biosynthesis	P03049	Glucosamine-1-phosphate acetyltransferase	DEIRA|EnsemblGenome=DR_0808|UniProtKB=Q9RW61	Bifunctional protein GlmU	ISS			PTHR43584:SF3	BIFUNCTIONAL PROTEIN GLMU
P04393	Ras Pathway	P04553	PAK	MACMU|Ensembl=ENSMMUG00000001387|UniProtKB=F7D0B4	Uncharacterized protein	ISS	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	ORNAN|Ensembl=ENSOANG00000007405|UniProtKB=F7CIV4	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00053	T cell activation	P01312	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	94313981	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04395	Vasopressin synthesis	P04593	Glycopeptide	DANRE|ZFIN=ZDB-GENE-030407-1|UniProtKB=F1QC27	Uncharacterized protein	IC			PTHR11681:SF14	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01417	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MOUSE|MGI=MGI=87889|UniProtKB=Q2MKA5	Neuronal acetylcholine receptor subunit alpha-5	IC	85270494	PubMed	PTHR18945:SF76	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	HUMAN|HGNC=4038|UniProtKB=Q9UP38	Frizzled-1	TAS	12549854	PubMed	PTHR11309:SF81	FRIZZLED-1
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00931	Integrin beta	PANTR|Ensembl=ENSPTRG00000002413|UniProtKB=H2Q1T1	Integrin beta	ISS	10706722	PubMed	PTHR10082:SF28	INTEGRIN BETA-1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04392	P53 pathway feedback loops 1	G04682	MDM-2	MOUSE|MGI=MGI=107934|UniProtKB=O35618	Protein Mdm4	ISS			PTHR13844:SF20	PROTEIN MDM4
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00059	p53 pathway	G04702	p53	MACMU|Ensembl=ENSMMUG00000008639|UniProtKB=P56424	Cellular tumor antigen p53	TAS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MOUSE|MGI=MGI=96273|UniProtKB=Q64264	5-hydroxytryptamine receptor 1A	ISS	12181435	PubMed	PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	MOUSE|MGI=MGI=1276116|UniProtKB=B2RWS6	Histone acetyltransferase p300	ISS	10823891	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	HUMAN|HGNC=10935|UniProtKB=Q05940	Synaptic vesicular amine transporter	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	IC	11535291	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00035	Interferon-gamma signaling pathway	P00961	STAT1	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=1764|UniProtKB=P33151	Cadherin-5	IDA	8120095	PubMed	PTHR24027:SF89	CADHERIN-5
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00046	Oxidative stress response	P01132	c-jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	12972619	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00004	Alzheimer disease-presenilin pathway	P00153	gammacatenin	MONDO|Ensembl=ENSMODG00000014681|UniProtKB=F7DNP7	Uncharacterized protein	ISS	9172160	PubMed	PTHR23315:SF12	JUNCTION PLAKOGLOBIN
P00010	B cell activation	P00388	PLC gamma2	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00004	Alzheimer disease-presenilin pathway	P00174	CD44 N-terminal fragment	MOUSE|MGI=MGI=88338|UniProtKB=P15379	CD44 antigen	IDA	12223485	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P00048	PI3 kinase pathway	P01196	PDK1	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	15531926	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05915	Opioid proenkephalin pathway	P05988	peptide E	MACMU|Ensembl=ENSMMUG00000006775|UniProtKB=F7H3N8	Uncharacterized protein	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00019	Endothelin signaling pathway	P00590	IP3 R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00565	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IGI	3045562	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P04395	Vasopressin synthesis	P04593	Glycopeptide	DANRE|ZFIN=ZDB-GENE-030407-2|UniProtKB=F8W5D0	Uncharacterized protein (Fragment)	ISS			PTHR11681:SF13	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8670|UniProtKB=Q9UN74	Protocadherin alpha-4	IDA	8120095	PubMed	PTHR24028:SF82	PROTOCADHERIN ALPHA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	BOVIN|Ensembl=ENSBTAG00000040329|UniProtKB=F1MMU1	Uncharacterized protein	ISS			PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00034	Integrin signalling pathway	P00925	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00054	Toll receptor signaling pathway	P01357	MEKK1	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=96273|UniProtKB=Q64264	5-hydroxytryptamine receptor 1A	IDA	2156831	PubMed	PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	RAT|RGD=2736|UniProtKB=P35439	Glutamate receptor ionotropic, NMDA 1	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00057	Wnt signaling pathway	P01451	Galpha	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	IDA	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P06664	Gonadotropin-releasing hormone receptor pathway	G06884	Zeb1	MOUSE|MGI=MGI=1344313|UniProtKB=Q64318	Zinc finger E-box-binding homeobox 1	RCA			PTHR24391:SF17	ZINC FINGER E-BOX-BINDING HOMEOBOX 1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00059	p53 pathway	G04694	p110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04580	TRH Receptor	XENTR|Xenbase=XB-GENE-992328|UniProtKB=F6X115	Uncharacterized protein	ISS	7509436	PubMed	PTHR24243:SF115	THYROTROPIN-RELEASING HORMONE RECEPTOR
P00048	PI3 kinase pathway	P01182	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00095	Nicastrin	HUMAN|HGNC=17091|UniProtKB=Q92542	Nicastrin	IDA	10993067	PubMed	PTHR21092:SF0	NICASTRIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00021	FGF signaling pathway	P00629	PP2A	CHICK|Ensembl=ENSGALG00000011840|UniProtKB=F1NLM6	Uncharacterized protein	ISS	11007767	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DANRE|ZFIN=ZDB-GENE-070112-342|UniProtKB=A1L271	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00034	Integrin signalling pathway	P00951	Jnk	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MOUSE|MGI=MGI=1351344|UniProtKB=Q68ED2	Metabotropic glutamate receptor 7	ISS			PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05913	Enkephalin release	P05977	G-Protein (s)	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00021	FGF signaling pathway	P00643	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00005	Angiogenesis	P00223	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	1718748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01360	IKKbeta	CANLF|Ensembl=ENSCAFG00000005526|UniProtKB=E2RKR0	Uncharacterized protein	ISS	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00005	Angiogenesis	P00252	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	8479536	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00036	Interleukin signaling pathway	P00965	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00624	14-3-3	DANRE|ZFIN=ZDB-GENE-030131-6583|UniProtKB=Q5PRD0	14-3-3 protein beta/alpha-A	ISS	10407019	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	PANTR|Ensembl=ENSPTRG00000012855|UniProtKB=H2QJA9	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF126	FRIZZLED-5
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05730	Endogenous cannabinoid signaling	P05746	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00057	Wnt signaling pathway	P01448	CBP	PANTR|Ensembl=ENSPTRG00000014418|UniProtKB=H2QLS0	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00053	T cell activation	P01300	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01417	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00970	Interleukin	HUMAN|HGNC=6018|UniProtKB=P05231	Interleukin-6	ISS			PTHR45110:SF1	INTERLEUKIN-6
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	IGI	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00047	PDGF signaling pathway	P01159	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	TAKRU|Ensembl=ENSTRUG00000009259|UniProtKB=H2TF39	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P04393	Ras Pathway	P04542	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	BOVIN|Ensembl=ENSBTAG00000019210|UniProtKB=F1MJV4	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00018	EGF receptor signaling pathway	P00551	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	RAT|RGD=1359133|UniProtKB=Q6AY07	Fructose-bisphosphate aldolase	ISS	4812352	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01182	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00059	p53 pathway	G04700	PAI	BOVIN|Ensembl=ENSBTAG00000014465|UniProtKB=P13909	Plasminogen activator inhibitor 1	ISS	10692390	PubMed	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00057	Wnt signaling pathway	P01465	Ggamma	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P05915	Opioid proenkephalin pathway	P05994	G-protein	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CANLF|Ensembl=ENSCAFG00000012181|UniProtKB=F2Z4N7	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00048	PI3 kinase pathway	P01187	IR	BOVIN|Ensembl=ENSBTAG00000012687|UniProtKB=F1MV64	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IDA	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P06664	Gonadotropin-releasing hormone receptor pathway	G06668	Rap1b	MOUSE|MGI=MGI=894315|UniProtKB=Q99JI6	Ras-related protein Rap-1b	RCA	10476970	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=99401|UniProtKB=Q60612	Adenosine receptor A1	ISS	11781138	PubMed	PTHR24246:SF1	ADENOSINE RECEPTOR A1
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00036	Interleukin signaling pathway	P00983	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DROME|FlyBase=FBgn0000489|UniProtKB=P16912	Protein kinase DC2	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	ORYSJ|EnsemblGenome=OS06G0154500|UniProtKB=Q84UI5	Mitogen-activated protein kinase 1	ISS			PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	ISS	14684598	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00034	Integrin signalling pathway	P00920	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00025	Hedgehog signaling pathway	P00682	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P02755	Methylmalonyl pathway	P03033	Propionyl-CoA carboxylase	CANLF|Ensembl=ENSCAFG00000007170|UniProtKB=F1PTU4	Uncharacterized protein	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MACMU|Ensembl=ENSMMUG00000016675|UniProtKB=F6VTB5	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=12781|UniProtKB=Q93097	Protein Wnt-2b	IDA	12549854	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014262|UniProtKB=F7BYS8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00632	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	IGI	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00774	Dynein complex	PANTR|Ensembl=ENSPTRG00000014379|UniProtKB=G2HG77	Dynein light chain 4, axonemal	ISS	9454836	PubMed	PTHR11886:SF2	DYNEIN LIGHT CHAIN 4, AXONEMAL
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=107469|UniProtKB=Q8K3R3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	15611108	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	DICPU|Gene=DICPUDRAFT_57324|UniProtKB=F0ZVH9	Putative uncharacterized protein rasS	ISS	8290260	PubMed	PTHR24070:SF380	RAS-LIKE PROTEIN RASS
P00054	Toll receptor signaling pathway	P01375	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00797	p53	CHICK|Ensembl=ENSGALG00000007324|UniProtKB=F1N8Z7	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00034	Integrin signalling pathway	P00951	Jnk	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IDA	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	IDA	12846562	PubMed	PTHR10202:SF13	PRESENILIN-2
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00059	p53 pathway	P04609	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	ISS	96320556	PubMed	PTHR10048:SF14	PI-3 KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MACMU|Ensembl=ENSMMUG00000009759|UniProtKB=F6ZIH3	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF504	MYOSIN-13
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	SCHMA|EnsemblGenome=Smp_042160|UniProtKB=G4VJT9	Fructose-bisphosphate aldolase	IDA	9794637	PubMed	PTHR11627:SF20	FRUCTOSE-BISPHOSPHATE ALDOLASE
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	DICDI|dictyBase=DDB_G0290263|UniProtKB=Q9XZE5	Serine/threonine-protein phosphatase 2A catalytic subunit A	ISS	10452519	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CHICK|Ensembl=ENSGALG00000011809|UniProtKB=F1NMB0	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01412	HSP27	ANOGA|EnsemblGenome=AGAP005548|UniProtKB=Q7Q723	AGAP005548-PA	ISS			PTHR11527:SF252	HEAT SHOCK PROTEIN BETA-11
P00018	EGF receptor signaling pathway	P00545	JNK1-3	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00038	JAK/STAT signaling pathway	P01027	STAT	MONDO|Ensembl=ENSMODG00000028212|UniProtKB=F7BYN4	Signal transducer and activator of transcription	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P05916	Opioid prodynorphin pathway	P06000	vasopressin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	18479080	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00036	Interleukin signaling pathway	P00973	PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P06959	CCKR signaling map	P07194	MAP2K1	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	RCA	12488236	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=894282|UniProtKB=O08858	Somatostatin receptor type 5	IDA	12562507	PubMed	PTHR24229:SF20	SOMATOSTATIN RECEPTOR TYPE 5
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CHLRE|EnsemblGenome=CHLREDRAFT_24392|UniProtKB=A8JAV1	Actin	IDA			PTHR11937:SF155	ACTIN-5C-RELATED
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=98961|UniProtKB=P24383	Protein Wnt-7a	IDA	11266476	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00048	PI3 kinase pathway	P01185	SOS	CHICK|Ensembl=ENSGALG00000013224|UniProtKB=F1NMA4	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IDA	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00034	Integrin signalling pathway	P00951	Jnk	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04555	PDK	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	IDA	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00034	Integrin signalling pathway	P00907	ERK	HUMAN|HGNC=6855|UniProtKB=Q99759	Mitogen-activated protein kinase kinase kinase 3	IC			PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P04393	Ras Pathway	P04560	AP1	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00916	Ras	CHICK|Ensembl=ENSGALG00000006885|UniProtKB=P08642	GTPase HRas	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P02725	Allantoin degradation	P02820	Ureidoglycolate dehydrogenase	ECOLI|EcoGene=EG13624|UniProtKB=P77555	Ureidoglycolate dehydrogenase (NAD(+))	ISS			PTHR11091:SF4	UREIDOGLYCOLATE DEHYDROGENASE  NAD +
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=12782|UniProtKB=P56703	Proto-oncogene Wnt-3	IDA	8717036	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	IC	11956331	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00029	Huntington disease	P00777	CBP	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00052	TGF-beta signaling pathway	P01286	TGFbeta	RAT|RGD=3115|UniProtKB=O35312	Growth/differentiation factor 8	TAS	9759503	PubMed	PTHR11848:SF150	GROWTH/DIFFERENTIATION FACTOR 8
P04397	p53 pathway by glucose deprivation	P04640	p53	MOUSE|MGI=MGI=98834|UniProtKB=P02340	Cellular tumor antigen p53	TAS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00005	Angiogenesis	P00229	SPK	HUMAN|HGNC=11240|UniProtKB=Q9NYA1	Sphingosine kinase 1	IDA	12391145	PubMed	PTHR12358:SF47	SPHINGOSINE KINASE 1
P00048	PI3 kinase pathway	P01182	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00021	FGF signaling pathway	P00644	p38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IGI	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00021	FGF signaling pathway	P00627	ERK1-2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01171	PLCgamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00060	Ubiquitin proteasome pathway	P01491	E2	HUMAN|HGNC=12473|UniProtKB=P63146	Ubiquitin-conjugating enzyme E2 B	ISS			PTHR43898:SF6	UBIQUITIN-CONJUGATING ENZYME E2 B
P05916	Opioid prodynorphin pathway	P06002	G-protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00590	IP3 R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00009	Axon guidance mediated by netrin	P00357	Netrin	MACMU|Ensembl=ENSMMUG00000008197|UniProtKB=F7H0F3	Uncharacterized protein	ISS			PTHR10574:SF28	NETRIN-G1
P04398	p53 pathway feedback loops 2	P04649	Myc	TAKRU|Ensembl=ENSTRUG00000000102|UniProtKB=H2RJA9	Signal transducer and activator of transcription	ISS			PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00057	Wnt signaling pathway	P01444	Wnt	MACMU|Ensembl=ENSMMUG00000006915|UniProtKB=F7EZ32	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00050	Plasminogen activating cascade	P01262	pro-uPA	HUMAN|HGNC=9052|UniProtKB=P00749	Urokinase-type plasminogen activator	ISS	137114	gi	PTHR24264:SF38	UROKINASE-TYPE PLASMINOGEN ACTIVATOR
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00045	Notch signaling pathway	P01118	Numb	MACMU|Ensembl=ENSMMUG00000020196|UniProtKB=F6WLR7	Uncharacterized protein	ISS	8755477	PubMed	PTHR11232:SF33	PROTEIN NUMB HOMOLOG
P00012	Cadherin signaling pathway	P00470	F-actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	IC	14684598	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00018	EGF receptor signaling pathway	P00564	Rac	DICDI|dictyBase=DDB_G0268622|UniProtKB=P34145	Rho-related protein rac1B	IGI	8649368	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	PANTR|Ensembl=ENSPTRG00000001102|UniProtKB=H2QZR9	RAP1A, member of RAS oncogene family	ISS	1904317	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00020	FAS signaling pathway	P00615	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MACMU|Ensembl=ENSMMUG00000010184|UniProtKB=F6SR09	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00010	B cell activation	P00367	NFAT	HUMAN|HGNC=7775|UniProtKB=O95644	Nuclear factor of activated T-cells, cytoplasmic 1	IDA	12015605	PubMed	PTHR12533:SF5	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00009	Axon guidance mediated by netrin	P00359	NFAT	MACMU|Ensembl=ENSMMUG00000012657|UniProtKB=F7E7J1	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P02740	De novo pyrimidine ribonucleotides biosythesis	P02928	Dihydroorotase	ECOLI|EcoGene=EG10806|UniProtKB=P05020	Dihydroorotase	RCA			PTHR43137:SF1	DIHYDROOROTASE
P00048	PI3 kinase pathway	P01179	PKB	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00010	B cell activation	P00379	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00018	EGF receptor signaling pathway	P00565	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	CHICK|Ensembl=ENSGALG00000017238|UniProtKB=F1NWG3	Uncharacterized protein	ISS	14614461	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00005	Angiogenesis	P00220	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	P17325	SPACC	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00046	Oxidative stress response	P01135	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P02723	Adenine and hypoxanthine salvage pathway	P02804	Hypoxanthine phosphoribosyl transferase	TRYB2|Gene=Tb10.70.6650|UniProtKB=Q38CA0	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PUCGT|EnsemblGenome=PGTG_12204|UniProtKB=E3KPL3	Tubulin beta chain	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00030	Hypoxia response via HIF activation	P00823	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P00034	Integrin signalling pathway	P00924	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02784	Tyrosine biosynthesis	P03212	Chorismate mutase	BACSU|EnsemblGenome=BSU22690|UniProtKB=P19080	Chorismate mutase AroH	ISS			PTHR21164:SF0	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00034	Integrin signalling pathway	P00918	Caveolin	RAT|RGD=2280|UniProtKB=P41350	Caveolin-1	IPI	9741627	PubMed	PTHR10844:SF18	CAVEOLIN-1
P04392	P53 pathway feedback loops 1	P04538	Pirh-2	MOUSE|MGI=MGI=1915348|UniProtKB=Q9CR50	RING finger and CHY zinc finger domain-containing protein 1	ISS	607680	OMIM	PTHR21319:SF20	RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1
P00019	Endothelin signaling pathway	P00587	Raf-1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IGI	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00034	Integrin signalling pathway	P00936	PI3K	XENTR|Xenbase=XB-GENE-6067221|UniProtKB=F6Z0J4	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00948	Rho	ORNAN|Ensembl=ENSOANG00000008835|UniProtKB=F7FR08	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00021	FGF signaling pathway	P00644	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	ISS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	CHICK|Ensembl=ENSGALG00000011905|UniProtKB=F1NHT7	Uncharacterized protein	IDA	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	15470041	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00005	Angiogenesis	P00244	MAPKAPK2/3	MOUSE|MGI=MGI=109298|UniProtKB=P49138	MAP kinase-activated protein kinase 2	ISS	8262198	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00045	Notch signaling pathway	P01115	Neurotic	MONDO|Ensembl=ENSMODG00000009731|UniProtKB=F6XAH5	Alpha-(1,6)-fucosyltransferase	ISS			PTHR13132:SF29	ALPHA- 1,6 -FUCOSYLTRANSFERASE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00047	PDGF signaling pathway	P01168	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	MACMU|Ensembl=ENSMMUG00000005147|UniProtKB=O77680	D(1A) dopamine receptor	ISS	15328036	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05918	p38 MAPK pathway	P06031	p38alpha	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00036	Interleukin signaling pathway	P00990	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000005917|UniProtKB=F6QM53	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	PANTR|Ensembl=ENSPTRG00000014576|UniProtKB=H2QLZ9	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P04393	Ras Pathway	P04553	PAK	CANLF|Ensembl=ENSCAFG00000013067|UniProtKB=E2RJA0	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00036	Interleukin signaling pathway	P00965	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IC	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	BOVIN|Ensembl=ENSBTAG00000021741|UniProtKB=F1MNR5	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00020	FAS signaling pathway	P00615	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02763	Peptidoglycan biosynthesis	P03088	UDP-N-acetylmuramate dehydrogenase	AQUAE|EnsemblGenome=aq_511|UniProtKB=O66799	UDP-N-acetylenolpyruvoylglucosamine reductase	ISS			PTHR21071:SF4	UDP-N-ACETYLENOLPYRUVOYLGLUCOSAMINE REDUCTASE
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	CANLF|Ensembl=ENSCAFG00000000588|UniProtKB=E2RQ99	Uncharacterized protein	ISS			PTHR43521:SF1	ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00564	Rac	ARATH|TAIR=AT3G48040|UniProtKB=Q9SU67	Rac-like GTP-binding protein ARAC8	ISS			PTHR24072:SF255	RAC-LIKE GTP-BINDING PROTEIN ARAC10-RELATED
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	RCA	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	BRAFL|Gene=BRAFLDRAFT_122664|UniProtKB=C3ZIB9	Putative uncharacterized protein	ISS			PTHR24072:SF192	CDC42 HOMOLOG
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01185	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00003	Alzheimer disease-amyloid secretase pathway	P00093	Tip60	MOUSE|MGI=MGI=1860297|UniProtKB=B2RUJ5	Amyloid beta A4 precursor protein-binding family A member 1	ISS			PTHR12345:SF14	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 1
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02774	Salvage pyrimidine deoxyribonucleotides	P03148	Thymidine phosphorylase	ECOLI|EcoGene=EG10219|UniProtKB=P07650	Thymidine phosphorylase	ISS	9278503	PubMed	PTHR10515:SF0	THYMIDINE PHOSPHORYLASE
P00047	PDGF signaling pathway	P01173	STAT	BOVIN|Gene=STAT5A|UniProtKB=Q95115	Signal transducer and activator of transcription 5A	ISS	95188889	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	CANLF|Gene=FZD6|UniProtKB=Q8WMU5	Frizzled-6	TAS	11212302	PubMed	PTHR11309:SF75	FRIZZLED-6
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00019	Endothelin signaling pathway	P00570	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	88234494	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	CANLF|Ensembl=ENSCAFG00000000760|UniProtKB=E2R9L4	Uncharacterized protein	ISS	9305639	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	IC	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	IDA	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CHICK|Ensembl=ENSGALG00000007794|UniProtKB=A9YZQ5	Dopamine receptor 2 protein transcript variant 1	ISS	11861492	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MONDO|Ensembl=ENSMODG00000018204|UniProtKB=F6PGX6	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00006	Apoptosis signaling pathway	P00269	MAPK	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	ISS	12001934	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	TAS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=1351341|UniProtKB=Q68EF4	Metabotropic glutamate receptor 4	ISS	12488551	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	ARATH|TAIR=AT4G34460|UniProtKB=P49177	Guanine nucleotide-binding protein subunit beta	ISS	11313908	PubMed	PTHR19850:SF48	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00057	Wnt signaling pathway	P01465	Ggamma	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=107469|UniProtKB=Q8K3R3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	7822322	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00057	Wnt signaling pathway	P01455	Smad4	HUMAN|HGNC=6771|UniProtKB=Q99717	Mothers against decapentaplegic homolog 5	ISS	12736218	PubMed	PTHR13703:SF36	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P02736	Coenzyme A biosynthesis	P02884	Dephospho-CoA kinase	YEAST|SGD=S000002604|UniProtKB=Q03941	Dephospho-CoA kinase CAB5	ISS			PTHR10695:SF35	DEPHOSPHO-COA KINASE DOMAIN-CONTAINING PROTEIN
P05913	Enkephalin release	P05972	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00023	General transcription regulation	P00658	TBP-associated factors	DROME|FlyBase=FBgn0022724|UniProtKB=Q9VWY6	Transcription initiation factor TFIID subunit 8	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00005	Angiogenesis	P00223	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=3233|UniProtKB=P33533	Delta-type opioid receptor	IDA	11259498	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00034	Integrin signalling pathway	P00931	Integrin beta	HUMAN|HGNC=6164|UniProtKB=O95965	Integrin beta-like protein 1	IDA	3487386	PubMed	PTHR10082:SF3	INTEGRIN BETA-LIKE PROTEIN 1
P00018	EGF receptor signaling pathway	P00552	Ras	DICDI|dictyBase=DDB_G0292996|UniProtKB=P03967	Ras-like protein rasD	IGI	6091907	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00029	Huntington disease	P00796	Kainate receptor	RAT|RGD=71027|UniProtKB=P42264	Glutamate receptor ionotropic, kainate 3	IDA	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00018	EGF receptor signaling pathway	P00564	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	10891487	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00021	FGF signaling pathway	P00628	JNK1-3	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00034	Integrin signalling pathway	P00910	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	4504111	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MOUSE|MGI=MGI=2150393|UniProtKB=Q91ZU9	Glutamate receptor ionotropic, NMDA 3B	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	STRPU|Gene=CYIIIB|UniProtKB=P18499	Actin, cytoskeletal 3B	ISS	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00030	Hypoxia response via HIF activation	P00819	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02781	Threonine biosynthesis	P03189	Aspartate kinase	RHOBA|EnsemblGenome=RB8926|UniProtKB=Q7UMB6	Probable aspartokinase	ISS			PTHR21499:SF3	ASPARTOKINASE
P00050	Plasminogen activating cascade	P01253	Fibrin	MOUSE|MGI=MGI=95526|UniProtKB=Q8VCM7	Fibrinogen gamma chain	IDA	11686323	PubMed	PTHR19143:SF338	FIBRINOGEN GAMMA CHAIN
P00005	Angiogenesis	P00235	c-Fos	XENTR|Xenbase=XB-GENE-866811|UniProtKB=F7EI91	Uncharacterized protein (Fragment)	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00010	B cell activation	P00371	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	9298898	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00629	PP2A	CAEBR|Gene=CBG03807|UniProtKB=A8WWS6	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B	ISS	12019228	PubMed	PTHR11871:SF0	PROTEIN PHOSPHATASE PP2A 55 KDA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00048	PI3 kinase pathway	P01192	p110	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00015	Circadian clock system	G01499	per	MACMU|Ensembl=ENSMMUG00000021798|UniProtKB=F7ESU2	Uncharacterized protein	ISS	20570170	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P02763	Peptidoglycan biosynthesis	P03086	N-acetylglucosamine-1-phosphate uridyltransferase	FUSNN|EnsemblGenome=FN1991|UniProtKB=Q8RHM3	Bifunctional protein GlmU	ISS			PTHR43584:SF3	BIFUNCTIONAL PROTEIN GLMU
P00011	Blood coagulation	P00443	Fibrin polymer cross-linked	PANTR|Ensembl=ENSPTRG00000016534|UniProtKB=H2QQB4	Uncharacterized protein	ISS	11761631	gi	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P02726	Aminobutyrate degradation	P02825	4-aminobutyrate aminotransferase	EMENI|EnsemblGenome=CADANIAG00008938|UniProtKB=P14010	4-aminobutyrate aminotransferase	ISS	2505051	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00038	JAK/STAT signaling pathway	P01034	Jak	PANTR|Ensembl=ENSPTRG00000000825|UniProtKB=H2PZ66	Tyrosine-protein kinase	ISS	11929133	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00053	T cell activation	P01332	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00632	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IGI	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00587	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00623	FGF	CHICK|Ensembl=ENSGALG00000007219|UniProtKB=Q9W6A1	Fibroblast growth factor	ISS	12815063	PubMed	PTHR11486:SF17	FIBROBLAST GROWTH FACTOR 12
P00047	PDGF signaling pathway	P01161	Raf	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS	12068308	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00012	Cadherin signaling pathway	P00470	F-actin	ARATH|TAIR=AT2G42090|UniProtKB=P93738	Putative actin-9	IC	11889126	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00005	Angiogenesis	P00239	Eph	DANRE|ZFIN=ZDB-GENE-990415-67|UniProtKB=O73874	Ephrin-B2a	ISS			PTHR11304:SF18	EPHRIN-B2
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	IDA	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00029	Huntington disease	P00796	Kainate receptor	CHICK|Ensembl=ENSGALG00000015434|UniProtKB=F1NU20	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00056	VEGF signaling pathway	P01407	Erk	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00207	Crk	DANRE|ZFIN=ZDB-GENE-040426-2951|UniProtKB=Q6PH06	Uncharacterized protein	ISS			PTHR19969:SF9	CRK-LIKE PROTEIN
P00012	Cadherin signaling pathway	P00462	Casein kinase II	ORNAN|Ensembl=ENSOANG00000012115|UniProtKB=F7F9Q9	Uncharacterized protein	ISS	10806215	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	RAT|RGD=3852|UniProtKB=P80204	TGF-beta receptor type-1	TAS	9395284	PubMed	PTHR23255:SF61	TGF-BETA RECEPTOR TYPE-1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	ISS	176892	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01447	Dishevelled	HUMAN|HGNC=3087|UniProtKB=Q92997	Segment polarity protein dishevelled homolog DVL-3	ISS	11212302	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P00005	Angiogenesis	P00220	c-Jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	MACMU|Ensembl=ENSMMUG00000020819|UniProtKB=F7HSM1	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	DROME|FlyBase=FBgn0003416|UniProtKB=Q9VXH3	Phosphoinositide phospholipase C	ISS			PTHR10336:SF91	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00015	Circadian clock system	P00501	Clock	DANRE|ZFIN=ZDB-GENE-030408-2|UniProtKB=B3DH92	Clock3 protein	ISS			PTHR23042:SF2	CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT
P04393	Ras Pathway	P04552	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IDA	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00047	PDGF signaling pathway	P01148	Grb2	BOVIN|Ensembl=ENSBTAG00000003707|UniProtKB=A6QLK6	GRB2-related adapter protein	ISS	51702266	gi	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P00021	FGF signaling pathway	P00629	PP2A	BOVIN|Ensembl=ENSBTAG00000000754|UniProtKB=A2VDZ0	Protein phosphatase 2, regulatory subunit B', alpha isoform	ISS	10092233	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	G04694	p110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	XENTR|Xenbase=XB-GENE-481530|UniProtKB=F6U298	Uncharacterized protein	ISS	10683140	PubMed	PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00047	PDGF signaling pathway	P01149	MNK1/2	HUMAN|HGNC=7111|UniProtKB=Q9HBH9	MAP kinase-interacting serine/threonine-protein kinase 2	ISS	11463832	PubMed	PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00546	GAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	IGI	2574500	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00057	Wnt signaling pathway	P01448	CBP	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00057	Wnt signaling pathway	P01428	Frizzled	CANLF|Ensembl=ENSCAFG00000008293|UniProtKB=E2R9M9	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF22	FRIZZLED-3
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	97449291	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00010	B cell activation	P00398	IP3R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	IGI	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P06587	Nicotine pharmacodynamics pathway	P06596	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	11384839	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P05915	Opioid proenkephalin pathway	P05992	met-Enkephalin	MACMU|Ensembl=ENSMMUG00000006775|UniProtKB=F7H3N8	Uncharacterized protein	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P04398	p53 pathway feedback loops 2	P04661	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	ISS	10799299	PubMed	PTHR10048:SF14	PI-3 KINASE
P00048	PI3 kinase pathway	P01176	JAK	PANTR|Ensembl=ENSPTRG00000020744|UniProtKB=H2QWZ4	Tyrosine-protein kinase	ISS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	STRPU|EnsemblGenome=SPU_006797|UniProtKB=W4XTP5	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00047	PDGF signaling pathway	P01161	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00048	PI3 kinase pathway	P01192	p110	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04568	MKK3/6	XENTR|Xenbase=XB-GENE-944183|UniProtKB=F7EJU0	Uncharacterized protein (Fragment)	RCA			PTHR24361:SF645	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	12810719	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00048	PI3 kinase pathway	P01188	Gbetagamma	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00051	TCA cycle	P01267	Citrate Synthase	ECOLI|EcoGene=EG10402|UniProtKB=P0ABH7	Citrate synthase	ISS	15829999	gi	PTHR42871:SF1	CITRATE SYNTHASE
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00045	Notch signaling pathway	P01118	Numb	MOUSE|MGI=MGI=107423|UniProtKB=Q9QZS3	Protein numb homolog	IEP	8755477	PubMed	PTHR11232:SF33	PROTEIN NUMB HOMOLOG
P02738	De novo purine biosynthesis	P02902	ADP reductase	FUSNN|EnsemblGenome=FN0102|UniProtKB=Q8RH18	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00048	PI3 kinase pathway	P01185	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02751	Lysine biosynthesis	P03009	Aspartokinase	BACSU|EnsemblGenome=BSU16760|UniProtKB=Q04795	Aspartokinase 1	ISS			PTHR21499:SF41	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01159	SOS	DICDI|dictyBase=DDB_G0281573|UniProtKB=Q54TK8	Ras guanine nucleotide exchange factor P	ISS			PTHR23113:SF309	RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR P
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01146	Ikk	MACMU|Ensembl=ENSMMUG00000019357|UniProtKB=F6TAF3	Elongator complex protein 1	ISS			PTHR12747:SF0	ELONGATOR COMPLEX PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CHICK|Ensembl=ENSGALG00000011086|UniProtKB=P68139	Actin, alpha skeletal muscle	ISS	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00025	Hedgehog signaling pathway	P00682	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00020	FAS signaling pathway	P00615	JNK	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	TAS	10514528	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00005	Angiogenesis	P00251	cPLA2	DANRE|ZFIN=ZDB-GENE-990415-45|UniProtKB=P50392	Cytosolic phospholipase A2	ISS	94299545	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04393	Ras Pathway	P04556	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00807	Actin	ARATH|TAIR=AT5G59370|UniProtKB=P53494	Actin-4	IDA	14684598	PubMed	PTHR11937:SF366	ACTIN-4
P00034	Integrin signalling pathway	P00916	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IPI	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00017	DNA replication	P00532	Hel	HUMAN|HGNC=2939|UniProtKB=P51530	DNA replication ATP-dependent helicase/nuclease DNA2	RCA			PTHR10887:SF14	DNA REPLICATION ATP-DEPENDENT HELICASE/NUCLEASE DNA2
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00049	Parkinson disease	P01227	20S proteasome	RAT|RGD=61846|UniProtKB=P21670	Proteasome subunit alpha type-4	ISS	12859888	PubMed	PTHR11599:SF13	PROTEASOME SUBUNIT ALPHA TYPE-4
P00057	Wnt signaling pathway	P01465	Ggamma	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00036	Interleukin signaling pathway	P00990	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	ARATH|TAIR=AT2G22250|UniProtKB=Q9SIE1	Bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase	ISS			PTHR43795:SF2	BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE
P04398	p53 pathway feedback loops 2	P04669	ATM	MACMU|Ensembl=ENSMMUG00000004153|UniProtKB=F6XCB4	Uncharacterized protein	ISS	10196661	PubMed	PTHR11139:SF72	SERINE-PROTEIN KINASE ATM
P00047	PDGF signaling pathway	P01160	IP3 receptor	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	TAS	12885769	PubMed	PTHR10202:SF13	PRESENILIN-2
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	XENTR|Xenbase=XB-GENE-483455|UniProtKB=Q0IHM5	Receptor protein serine/threonine kinase	ISS	10683140	PubMed	PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P00018	EGF receptor signaling pathway	P00564	Rac	ENTHI|EnsemblGenome=EHI_181250|UniProtKB=C4M5Z7	Rho family GTPase	IGI	4757952	gi	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05964	GNAZ	CANLF|Ensembl=ENSCAFG00000013663|UniProtKB=E2R3J3	Uncharacterized protein	ISS	16814816	PubMed	PTHR10218:SF65	GUANINE NUCLEOTIDE-BINDING PROTEIN G Z  SUBUNIT ALPHA
P00005	Angiogenesis	P00203	Erk	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00012	Cadherin signaling pathway	P00466	EGFR	PANTR|Ensembl=ENSPTRG00000019196|UniProtKB=H2QUL1	Receptor protein-tyrosine kinase	ISS	90258888	PubMed	PTHR24416:SF91	EPIDERMAL GROWTH FACTOR RECEPTOR
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	XENTR|Ensembl=ENSXETG00000030140|UniProtKB=F7EP58	Uncharacterized protein (Fragment)	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00011	Blood coagulation	P00405	FVIII	MOUSE|MGI=MGI=88383|UniProtKB=Q06194	Coagulation factor VIII	ISS	6679733	gi	PTHR45309:SF1	COAGULATION FACTOR VIII
P00059	p53 pathway	P04610	Cyclin E	DANRE|ZFIN=ZDB-GENE-980526-168|UniProtKB=P47794	G1/S-specific cyclin-E1	NAS	18858511	gi	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P05913	Enkephalin release	P05972	PKA	DANRE|ZFIN=ZDB-GENE-040426-2427|UniProtKB=F1Q6C0	Uncharacterized protein (Fragment)	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00020	FAS signaling pathway	P00615	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	TAS	10851062	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	IC	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	CHICK|Ensembl=ENSGALG00000006576|UniProtKB=E1BUE5	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00059	p53 pathway	P04623	CBP	CAEEL|WormBase=WBGene00009595|UniProtKB=Q7JMS5	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00019	Endothelin signaling pathway	P00589	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	NAS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00976	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IPI	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00009	Axon guidance mediated by netrin	P00359	NFAT	PANTR|Ensembl=ENSPTRG00000013628|UniProtKB=H2R4F5	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01150	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00021	FGF signaling pathway	P00629	PP2A	RAT|RGD=3380|UniProtKB=P63331	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00269	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	11251832	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	CANAL|EnsemblGenome=CaO19.1760|UniProtKB=Q59XU5	Ras-like protein 1	ISS	99445463	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	TRYB2|Gene=Tb11.01.7800|UniProtKB=Q381H3	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00012	Cadherin signaling pathway	P00470	F-actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347742|UniProtKB=E9FZ00	Cytoplasmatic actin	ISS	10974003	PubMed	PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CANLF|Ensembl=ENSCAFG00000015708|UniProtKB=F2Z4N0	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	CAEEL|WormBase=WBGene00000552|UniProtKB=O16305	Calmodulin	ISS	7514101	PubMed	PTHR23050:SF236	CALMODULIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	BOVIN|Ensembl=ENSBTAG00000008967|UniProtKB=P61223	Ras-related protein Rap-1b	ISS	10476970	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00018	EGF receptor signaling pathway	P00564	Rac	ARATH|TAIR=AT5G45970|UniProtKB=Q38903	Rac-like GTP-binding protein ARAC2	ISS	12932731	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00034	Integrin signalling pathway	P00941	Integrin alpha	RAT|RGD=1311711|UniProtKB=F1LUU1	Protein Itga11	ISS	3487386	PubMed	PTHR23220:SF21	INTEGRIN ALPHA-11
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MOUSE|MGI=MGI=88396|UniProtKB=P12657	Muscarinic acetylcholine receptor M1	TAS	8100450	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	ORNAN|Ensembl=ENSOANG00000006119|UniProtKB=F6WTY3	Uncharacterized protein	ISS	12374786	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	PANTR|Ensembl=ENSPTRG00000003554|UniProtKB=H2Q3I3	Low density lipoprotein receptor-related protein 4	ISS	11907044	PubMed	PTHR44017:SF4	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00059	p53 pathway	P04624	Cdc25C	MOUSE|MGI=MGI=88350|UniProtKB=P48967	M-phase inducer phosphatase 3	IDA	12937170	PubMed	PTHR10828:SF64	M-PHASE INDUCER PHOSPHATASE 3
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BOVIN|Ensembl=ENSBTAG00000012914|UniProtKB=F1MHG3	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	TAS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02785	Valine biosynthesis	P03218	Dihydroxy isovalerate dehydratase	BACTN|EnsemblGenome=BT_2078|UniProtKB=Q8A608	Dihydroxy-acid dehydratase	ISS			PTHR43661:SF3	DIHYDROXY-ACID DEHYDRATASE
P00006	Apoptosis signaling pathway	P00269	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01444	Wnt	PANTR|Ensembl=ENSPTRG00000001108|UniProtKB=H2PZP0	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00049	Parkinson disease	P01218	alpha-Synuclein	CANLF|Ensembl=ENSCAFG00000009880|UniProtKB=E2RDD9	Alpha-synuclein	ISS	9278044	PubMed	PTHR13820:SF5	ALPHA-SYNUCLEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Gene=OPRM1|UniProtKB=P79350	Mu-type opioid receptor	IDA	11259498	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00638	PLCgamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01192	p110	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	HUMAN|HGNC=1389|UniProtKB=Q00975	Voltage-dependent N-type calcium channel subunit alpha-1B	TAS	8386525	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00018	EGF receptor signaling pathway	G01511	SPRY	PANTR|Ensembl=ENSPTRG00000005951|UniProtKB=H2Q7P2	Sprouty homolog 2	ISS	12225946	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P00018	EGF receptor signaling pathway	P00563	Gab	MOUSE|MGI=MGI=108088|UniProtKB=Q9QYY0	GRB2-associated-binding protein 1	IGI	15356145	PubMed	PTHR12156:SF18	GRB2-ASSOCIATED-BINDING PROTEIN 1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00034	Integrin signalling pathway	P00925	MEK	MACMU|Ensembl=ENSMMUG00000019842|UniProtKB=F7FU91	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	TAS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00005	Angiogenesis	P00200	Dsh	PANTR|Ensembl=ENSPTRG00000015681|UniProtKB=H2QNU7	Dishevelled, dsh homolog 3	ISS	10409711	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	USTMA|Gene=UMAG_11232|UniProtKB=A0A0D1DMT3	Chromosome 22, whole genome shotgun sequence	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00056	VEGF signaling pathway	P01417	Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	ISS	12068308	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00022	General transcription by RNA polymerase I	P00657	TBP	METAC|EnsemblGenome=MA_4331|UniProtKB=Q8TI26	TATA-box-binding protein 1	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00036	Interleukin signaling pathway	P00980	IRS1/2	MOUSE|MGI=MGI=99454|UniProtKB=P35569	Insulin receptor substrate 1	IC	5031805	gi	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00057	Wnt signaling pathway	P01438	PP2A	HUMAN|HGNC=9309|UniProtKB=Q15172	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform	IDA	10092233	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00019	Endothelin signaling pathway	P00589	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00045	Notch signaling pathway	P01101	Su(H)	PANTR|Ensembl=ENSPTRG00000015968|UniProtKB=H2R2Q6	Uncharacterized protein	ISS	8406481	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00053	T cell activation	P01324	rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	10891487	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00057	Wnt signaling pathway	P01451	Galpha	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00010	B cell activation	P00383	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	TAKRU|Ensembl=ENSTRUG00000008018|UniProtKB=H2T5N4	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01446	Calcineurin	CHICK|Ensembl=ENSGALG00000005243|UniProtKB=E1C2T7	Serine/threonine-protein phosphatase	ISS	12091710	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00944	Actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	ISS	10974003	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000010953|UniProtKB=F1Q376	Phosphoinositide phospholipase C	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CAEEL|WormBase=WBGene00015478|UniProtKB=Q11179	Putative serine/threonine-protein kinase C05D10.2	IDA	10514528	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00049	Parkinson disease	P01211	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01411	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00029	Huntington disease	P00775	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	IDA	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00848	Grb	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8051109	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00572	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00947	Laminin	ANOGA|EnsemblGenome=AGAP001381|UniProtKB=Q7PXF5	AGAP001381-PA	IPI	2538453	PubMed	PTHR10574:SF303	LAMININ SUBUNIT BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	XENTR|Xenbase=XB-GENE-1004371|UniProtKB=F6R882	Uncharacterized protein	ISS	2433589	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00034	Integrin signalling pathway	P00916	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00021	FGF signaling pathway	P00633	Ras	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g247341|UniProtKB=A7STP5	Predicted protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00025	Hedgehog signaling pathway	P00692	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05912	Dopamine receptor mediated signaling pathway	P05962	DAT	MOUSE|MGI=MGI=94862|UniProtKB=Q61327	Sodium-dependent dopamine transporter	ISS	15135042	PubMed	PTHR11616:SF38	SODIUM-DEPENDENT DOPAMINE TRANSPORTER
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00623	FGF	CHICK|Gene=FGF8|UniProtKB=Q90722	Fibroblast growth factor 8	IGI	96232288	PubMed	PTHR11486:SF3	FIBROBLAST GROWTH FACTOR 8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	91298951	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00045	Notch signaling pathway	P01113	Pen-2	HUMAN|HGNC=9509|UniProtKB=P49810	Presenilin-2	IPI	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04564	MAPKAP	BOVIN|Ensembl=ENSBTAG00000038107|UniProtKB=F1MCX5	Uncharacterized protein	ISS	10779545	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IDA	3045562	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	IC	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00048	PI3 kinase pathway	P01181	GSK3	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00005	Angiogenesis	P00255	Notch	CANLF|Ensembl=ENSCAFG00000019633|UniProtKB=F1PDC7	Uncharacterized protein	ISS	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00018	EGF receptor signaling pathway	P00561	STAT	MACMU|Ensembl=ENSMMUG00000010707|UniProtKB=F7G8G5	Signal transducer and activator of transcription	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00010	B cell activation	P00397	IKK	RAT|RGD=1306661|UniProtKB=G3V926	Conserved helix-loop-helix ubiquitous kinase (Predicted)	ISS	14499113	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	LEIMA|EnsemblGenome=LmjF.32.2950|UniProtKB=Q9U1E1	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1693|UniProtKB=Q6P967	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	RCA	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	TAS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00005	Angiogenesis	P00238	Ras	MONDO|Gene=KRAS|UniProtKB=Q07983	GTPase KRas	ISS	3023884	PubMed	PTHR24070:SF186	GTPASE KRAS
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	RAT|RGD=621463|UniProtKB=G3V819	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	BOVIN|Ensembl=ENSBTAG00000009269|UniProtKB=F1MCM2	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00009	Axon guidance mediated by netrin	P00366	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	MOUSE|MGI=MGI=1934950|UniProtKB=Q8BK63	Casein kinase I isoform alpha	IDA	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01219	SAPK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	NAS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05913	Enkephalin release	P05975	GPCR (s)	DANRE|ZFIN=ZDB-GENE-010125-1|UniProtKB=B8JHS2	Uncharacterized protein	ISS	12093103	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	MOUSE|MGI=MGI=95819|UniProtKB=P35438	Glutamate receptor ionotropic, NMDA 1	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	CHICK|Ensembl=ENSGALG00000017178|UniProtKB=F1N982	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00188	Ets	HUMAN|HGNC=3488|UniProtKB=P14921	Protein C-ets-1	IDA	3060801	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05934	ELK1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	RCA	9644975	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	MOUSE|MGI=MGI=1349470|UniProtKB=Q9WVC5	Short transient receptor potential channel 7	IDA	11055438	PubMed	PTHR10117:SF9	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 7
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BOVIN|Ensembl=ENSBTAG00000006189|UniProtKB=P63258	Actin, cytoplasmic 2	ISS	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00029	Huntington disease	P00786	ARF	MACMU|Ensembl=ENSMMUG00000021324|UniProtKB=F6URI0	ADP-ribosylation factor-like protein 4D	ISS	12932731	PubMed	PTHR11711:SF137	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 4D
P00059	p53 pathway	P04615	MTA2	DROME|Gene=Dmel_CG2244|UniProtKB=A0A0B4KG70	Metastasis associated 1-like, isoform D	ISS			PTHR10865:SF29	METASTASIS ASSOCIATED 1-LIKE, ISOFORM D
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	IC	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	ISS	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00005	Angiogenesis	P00193	SOS-1	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01179	PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00317	Fos	XENTR|Xenbase=XB-GENE-866811|UniProtKB=F7EI91	Uncharacterized protein (Fragment)	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00925	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P05734	Synaptic vesicle trafficking	P05774	NSF	BOVIN|Ensembl=ENSBTAG00000008442|UniProtKB=F1MZU2	Uncharacterized protein	ISS	7969419	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00046	Oxidative stress response	P01131	MKP5	MACMU|Ensembl=ENSMMUG00000018580|UniProtKB=F6YFQ2	Uncharacterized protein	ISS			PTHR10159:SF37	DUAL SPECIFICITY PROTEIN PHOSPHATASE 16
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00507	Rho	PANTR|Ensembl=ENSPTRG00000001112|UniProtKB=H2PZP2	Ras homolog gene family, member C	ISS	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00029	Huntington disease	P00807	Actin	PRIPA|Gene=PPA17339|UniProtKB=H3F5B4	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF352	ACTIN
P00053	T cell activation	P01323	I kappa B	RAT|RGD=3171|UniProtKB=Q63746	NF-kappa-B inhibitor alpha	ISS	10869418	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00047	PDGF signaling pathway	P01155	Jak	RAT|RGD=2939|UniProtKB=Q62689	Tyrosine-protein kinase JAK2	ISS	12686512	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00056	VEGF signaling pathway	P01418	Paxillin	HUMAN|HGNC=14061|UniProtKB=O60711	Leupaxin	ISS			PTHR24216:SF23	LEUPAXIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01092	delta	DANRE|ZFIN=ZDB-GENE-030131-6665|UniProtKB=Q75XT1	Acetylcholine receptor delta subunit	ISS	85203892	PubMed	PTHR18945:SF61	ACETYLCHOLINE RECEPTOR SUBUNIT DELTA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01164	PDK1/2	CAEEL|WormBase=WBGene00021022|UniProtKB=Q9UA62	Uncharacterized protein	ISS			PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	YEAST|SGD=S000001295|UniProtKB=P07278	cAMP-dependent protein kinase regulatory subunit	IC	91298951	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00059	p53 pathway	P04623	CBP	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00049	Parkinson disease	P01230	Src kinase	BOVIN|Ensembl=ENSBTAG00000001523|UniProtKB=A7MB57	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF90	TYROSINE-PROTEIN KINASE YES
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00007	Axon guidance mediated by semaphorins	P00340	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05943	GRK2	HUMAN|HGNC=289|UniProtKB=P25098	Beta-adrenergic receptor kinase 1	RCA	10852916	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P00019	Endothelin signaling pathway	P00586	Gq	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00048	PI3 kinase pathway	P01181	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MACMU|Ensembl=ENSMMUG00000006253|UniProtKB=F7H582	Uncharacterized protein	ISS	10978539	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00624	14-3-3	BOVIN|Gene=YWHAB|UniProtKB=P68250	14-3-3 protein beta/alpha	IDA	10407019	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P05913	Enkephalin release	P05972	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04398	p53 pathway feedback loops 2	P04657	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00053	T cell activation	P01311	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05752	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	RCA	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02771	Pyrimidine Metabolism	P03130	Cytidine Deaminase	CAEEL|WormBase=WBGene00000391|UniProtKB=Q22922	CytiDine Deaminase	IEP	17551074	gi	PTHR11644:SF11	CYTIDINE DEAMINASE
P00019	Endothelin signaling pathway	P00566	ERK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	IGI	94131269	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00005	Angiogenesis	P00237	FRP	MOUSE|MGI=MGI=892032|UniProtKB=P97401	Secreted frizzled-related protein 3	ISS	9118218	PubMed	PTHR11309:SF97	SECRETED FRIZZLED-RELATED PROTEIN 3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00219	PKC	DROME|Gene=Dmel_CG7125|UniProtKB=A0A0B4KHC3	Serine/threonine-protein kinase	ISS			PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	XENTR|Xenbase=XB-GENE-977853|UniProtKB=F7EBE7	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MACMU|Ensembl=ENSMMUG00000016675|UniProtKB=F6VTB5	Uncharacterized protein	ISS	11554549	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00010	B cell activation	P00398	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	BOVIN|Ensembl=ENSBTAG00000034854|UniProtKB=F1N246	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00048	PI3 kinase pathway	P01177	P110ACT	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02724	Alanine biosynthesis	P02815	Branched chain amino acid aminotransferase	MOUSE|MGI=MGI=1276534|UniProtKB=O35855	Branched-chain-amino-acid aminotransferase, mitochondrial	ISS			PTHR11825:SF39	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	11035810	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	BOVIN|Ensembl=ENSBTAG00000002295|UniProtKB=F1N177	Uncharacterized protein	ISS	11390664	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P04393	Ras Pathway	P04557	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00056	VEGF signaling pathway	P01408	Akt/PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	1718748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00564	Rac	DROME|FlyBase=FBgn0010333|UniProtKB=P40792	Ras-related protein Rac1	IGI	95047333	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00053	T cell activation	P01316	MHC-antigen	HUMAN|HGNC=4935|UniProtKB=P28068	HLA class II histocompatibility antigen, DM beta chain	ISS	3112582	PubMed	PTHR19944:SF65	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DM BETA CHAIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00034	Integrin signalling pathway	P00948	Rho	CHICK|Ensembl=ENSGALG00000026313|UniProtKB=R4GI31	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF24	RHO-RELATED GTP-BINDING PROTEIN RHOE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	HUMAN|HGNC=9992|UniProtKB=O43665	Regulator of G-protein signaling 10	IDA	8756726	PubMed	PTHR10845:SF182	REGULATOR OF G-PROTEIN SIGNALING 10
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00048	PI3 kinase pathway	P01202	p85	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	IDA	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00561	STAT	BOVIN|Ensembl=ENSBTAG00000006335|UniProtKB=F1MGJ4	Signal transducer and activator of transcription	ISS	8085155	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00056	VEGF signaling pathway	P01419	Ets	BOVIN|Ensembl=ENSBTAG00000002341|UniProtKB=A5PJG9	ETS1 protein	ISS	3060801	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00018	EGF receptor signaling pathway	P00563	Gab	RAT|RGD=1311085|UniProtKB=A0A0G2JZD5	Protein Gab1	ISS	15356145	PubMed	PTHR12156:SF18	GRB2-ASSOCIATED-BINDING PROTEIN 1
P06216	SCW signaling pathway	P06333	FUR1	DROME|FlyBase=FBgn0004509|UniProtKB=P26016	Furin-like protease 1, isoforms 1/1-X/2	IEA	7737999	PubMed	PTHR42884:SF3	FURIN-LIKE PROTEASE 1, ISOFORMS 1/1-X/2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00013	Cell cycle	P00480	Proteasome	LEIMA|EnsemblGenome=LmjF.21.0760|UniProtKB=Q4QCD7	19S proteasome regulatory subunit	ISS	98146435	PubMed	PTHR10855:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12
P05915	Opioid proenkephalin pathway	P05989	leu-Enkephalin	DANRE|ZFIN=ZDB-GENE-030729-31|UniProtKB=A8E7S2	Uncharacterized protein	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IPI	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00020	FAS signaling pathway	P00600	PARP	MACMU|Ensembl=ENSMMUG00000016253|UniProtKB=F7GE72	Poly [ADP-ribose] polymerase	ISS	12101391	PubMed	PTHR10459:SF60	POLY  ADP-RIBOSE  POLYMERASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	MACMU|Ensembl=ENSMMUG00000006253|UniProtKB=F7H582	Uncharacterized protein	ISS	93028552	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8971|UniProtKB=O00443	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000010393|UniProtKB=F7D992	Uncharacterized protein	ISS	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000024992|UniProtKB=F6TUR3	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00048	PI3 kinase pathway	P01181	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	ECOLI|EcoGene=EG11372|UniProtKB=P68398	tRNA-specific adenosine deaminase	ISS			PTHR11079:SF149	TRNA-SPECIFIC ADENOSINE DEAMINASE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	HUMAN|HGNC=4584|UniProtKB=Q05586	Glutamate receptor ionotropic, NMDA 1	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00021	FGF signaling pathway	P00644	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00029	Huntington disease	P00807	Actin	PHANO|EnsemblGenome=SNOG_01139|UniProtKB=H2KNE6	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	CANAL|CGD=CAL0000855|UniProtKB=Q59XW4	Acetyl-coenzyme A synthetase	ISS			PTHR24095:SF14	ACETYL-COENZYME A SYNTHETASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00029	Huntington disease	P00780	Microtubule	TRIAD|EnsemblGenome=TriadG63686|UniProtKB=B3RQ31	Beta-tubulin	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04376	5HT4 type receptor mediated signaling pathway	P04431	5HT transporter	MACMU|Gene=SLC6A4|UniProtKB=Q9MYX0	Sodium-dependent serotonin transporter	ISS	14653308	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	HUMAN|HGNC=1401|UniProtKB=Q02641	Voltage-dependent L-type calcium channel subunit beta-1	ISS	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02748	Isoleucine biosynthesis	P02997	Acetolactate synthase	PSEAE|EnsemblGenome=PA2035|UniProtKB=Q9I280	Probable decarboxylase	ISS			PTHR18968:SF120	SUBFAMILY NOT NAMED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ARATH|TAIR=AT5G43010|UniProtKB=Q9SEI3	26S protease regulatory subunit 10B homolog A	ISS			PTHR23073:SF58	26S PROTEASE REGULATORY SUBUNIT 10B HOMOLOG A-RELATED
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000001384|UniProtKB=F7GL73	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00020	FAS signaling pathway	P00615	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_114535|UniProtKB=C3ZHN2	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P06959	CCKR signaling map	G06976	REG1A	HUMAN|HGNC=9951|UniProtKB=P05451	Lithostathine-1-alpha	RCA	17463184	PubMed	PTHR43993:SF7	LITHOSTATHINE-1-ALPHA
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CHICK|Ensembl=ENSGALG00000001334|UniProtKB=F1NLV4	Uncharacterized protein	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00019	Endothelin signaling pathway	P00568	PKC	CAEEL|WormBase=WBGene00018620|UniProtKB=O44588	Uncharacterized protein	ISS	15572354	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P00018	EGF receptor signaling pathway	P00539	14-3-3	XENTR|Xenbase=XB-GENE-951350|UniProtKB=Q0V9W8	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	ISS	10407019	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IGI	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00560	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	RAT|RGD=3851|UniProtKB=Q07258	Transforming growth factor beta-3	TAS	9759503	PubMed	PTHR11848:SF34	TRANSFORMING GROWTH FACTOR BETA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	HUMAN|HGNC=4574|UniProtKB=P48058	Glutamate receptor 4	ISS	12497607	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	SCHPO|PomBase=SPBC32H8.07|UniProtKB=Q10282	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00045	Notch signaling pathway	G01541	E(spl)-C genes	MACMU|Ensembl=ENSMMUG00000001081|UniProtKB=F6QM82	Uncharacterized protein	ISS			PTHR10985:SF8	HAIRY AND ENHANCER OF SPLIT-RELATED PROTEIN HELT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	RAT|RGD=2257|UniProtKB=P62161	Calmodulin	ISS			PTHR23050:SF311	CALMODULIN
P00022	General transcription by RNA polymerase I	P00649	TAF-IC	MONDO|Ensembl=ENSMODG00000012785|UniProtKB=F6S0M5	Uncharacterized protein	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00057	Wnt signaling pathway	P01435	SWI/SNF	HUMAN|HGNC=11106|UniProtKB=Q96GM5	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1	IDA	11532957	PubMed	PTHR13844:SF1	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D MEMBER 1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00006	Apoptosis signaling pathway	P00282	IGFR2	BOVIN|Gene=IGF2R|UniProtKB=P08169	Cation-independent mannose-6-phosphate receptor	IDA	11081635	PubMed	PTHR15071:SF17	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
P00034	Integrin signalling pathway	P00927	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00023	General transcription regulation	P00667	TFIIFbeta	PANTR|Ensembl=ENSPTRG00000005840|UniProtKB=H2R032	General transcription factor IIF subunit 2	ISS			PTHR10445:SF0	GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	BOVIN|Ensembl=ENSBTAG00000003054|UniProtKB=F1MC23	Tyrosine-protein kinase receptor	ISS	10226785	PubMed	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	1499560	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00049	Parkinson disease	P01233	Elk-1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	IDA	9644975	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00034	Integrin signalling pathway	P00931	Integrin beta	MOUSE|MGI=MGI=96615|UniProtKB=Q9Z0T9	Integrin beta-6	IDA	3487386	PubMed	PTHR10082:SF11	INTEGRIN BETA-6
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00010	B cell activation	P00371	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00747	Rhodopsin	HUMAN|HGNC=10012|UniProtKB=P08100	Rhodopsin	IDA	1634520	PubMed	PTHR24240:SF15	RHODOPSIN
P00005	Angiogenesis	P00221	JNK1	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01171	PLCgamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	DROME|FlyBase=FBgn0011286|UniProtKB=Q24498	Ryanodine receptor	ISS	15226293	PubMed	PTHR13715:SF79	RYANODINE RECEPTOR
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	DROME|FlyBase=FBgn0000043|UniProtKB=P02572	Actin-42A	ISS	10974003	PubMed	PTHR11937:SF369	ACTIN-42A
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	BOVIN|Ensembl=ENSBTAG00000021013|UniProtKB=Q3ZBU7	Tubulin beta-4A chain	ISS	9454836	PubMed	PTHR11588:SF253	TUBULIN BETA-4A CHAIN
P00005	Angiogenesis	P00204	PLD	HUMAN|HGNC=9068|UniProtKB=O14939	Phospholipase D2	ISS	9538008	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	BOVIN|Ensembl=ENSBTAG00000047202|UniProtKB=G3N3K3	Uncharacterized protein	ISS	11554554	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02756	N-acetylglucosamine metabolism	P03040	N-acetylneuraminate lyase	BOVIN|Ensembl=ENSBTAG00000002266|UniProtKB=Q29RY9	N-acetylneuraminate lyase	ISS			PTHR12128:SF21	N-ACETYLNEURAMINATE LYASE
P06959	CCKR signaling map	G07268	CXCL1	HUMAN|HGNC=4602|UniProtKB=P09341	Growth-regulated alpha protein	RCA	11518686	PubMed	PTHR10179:SF69	GROWTH-REGULATED ALPHA PROTEIN
P00057	Wnt signaling pathway	P01429	Axin	RAT|RGD=69259|UniProtKB=O70240	Axin-2	IDA	9554852	PubMed	PTHR10845:SF103	AXIN-2
P00005	Angiogenesis	P00181	SHP2	MOUSE|MGI=MGI=99511|UniProtKB=P35235	Tyrosine-protein phosphatase non-receptor type 11	ISS	8096088	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P04398	p53 pathway feedback loops 2	P04657	P110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01160	IP3 receptor	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	CANLF|Ensembl=ENSCAFG00000010787|UniProtKB=E2R3W6	Uncharacterized protein	ISS	1319557	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00034	Integrin signalling pathway	P00916	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	9332390	PubMed	PTHR10202:SF13	PRESENILIN-2
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00019	Endothelin signaling pathway	P00591	PLCbeta	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IGI	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01471	alpha-catenin	DANRE|ZFIN=ZDB-GENE-991207-24|UniProtKB=Q9PVF8	Catenin (Cadherin-associated protein), alpha	IDA	10456847	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	HUMAN|HGNC=11332|UniProtKB=P32745	Somatostatin receptor type 3	IDA			PTHR24229:SF42	SOMATOSTATIN RECEPTOR TYPE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01465	Ggamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00010	B cell activation	P00375	Calmodulin	DANRE|Ensembl=ENSDARG00000015050|UniProtKB=Q6PI52	Calmodulin	ISS	9753452	PubMed	PTHR23050:SF326	CALMODULIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	XENTR|Xenbase=XB-GENE-1005779|UniProtKB=F7E3I6	Uncharacterized protein	ISS	2039532	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	BACSU|EnsemblGenome=BSU37960|UniProtKB=P39616	Probable aldehyde dehydrogenase YwdH	IC	14724059	PubMed	PTHR43570:SF4	SUBFAMILY NOT NAMED
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00628	JNK1-3	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00049	Parkinson disease	P01242	Casein kinase I	MONDO|Ensembl=ENSMODG00000003587|UniProtKB=F7FPX9	Uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00059	p53 pathway	P04630	PP2A	CANLF|Ensembl=ENSCAFG00000006453|UniProtKB=F6X958	Serine/threonine-protein phosphatase	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	CANLF|Ensembl=ENSCAFG00000013778|UniProtKB=F6UQ33	Phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TAKRU|Ensembl=ENSTRUG00000007989|UniProtKB=P68140	Actin, alpha skeletal muscle A	IC	14684598	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P02772	Pyruvate metabolism	P03132	Pyruvate Kinase	HUMAN|HGNC=9020|UniProtKB=P30613	Pyruvate kinase PKLR	RCA			PTHR11817:SF31	PYRUVATE KINASE PKLR
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P05917	Opioid proopiomelanocortin pathway	P06004	Mu or Delta receptor	MONDO|Ensembl=ENSMODG00000008382|UniProtKB=F7CDR6	Uncharacterized protein (Fragment)	ISS	12093103	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00018	EGF receptor signaling pathway	P00547	PP2A	DANRE|ZFIN=ZDB-GENE-040426-2487|UniProtKB=Q803G3	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	XENTR|Xenbase=XB-GENE-491773|UniProtKB=F7CRN2	Uncharacterized protein	ISS	606023	OMIM	PTHR10917:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3
P00038	JAK/STAT signaling pathway	P01031	PIAS	BOVIN|Ensembl=ENSBTAG00000021634|UniProtKB=A6QQU9	PIAS3 protein	ISS	8682149	PubMed	PTHR10782:SF10	E3 SUMO-PROTEIN LIGASE PIAS3
P04393	Ras Pathway	P04552	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00049	Parkinson disease	P01212	p38 MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-070112-342|UniProtKB=A1L271	Uncharacterized protein	ISS	1499560	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04393	Ras Pathway	P04572	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MONDO|Ensembl=ENSMODG00000024440|UniProtKB=F7DJJ2	Muscarinic acetylcholine receptor	ISS	11166329	PubMed	PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00029	Huntington disease	P00807	Actin	PHYPA|Gene=PHYPADRAFT_226658|UniProtKB=A9TYG3	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05913	Enkephalin release	P05972	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00084	X11alpha	MACMU|Ensembl=ENSMMUG00000019339|UniProtKB=F6PW11	Uncharacterized protein	ISS	9614075	PubMed	PTHR12345:SF12	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 2
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00057	Wnt signaling pathway	P01428	Frizzled	MONDO|Ensembl=ENSMODG00000016310|UniProtKB=F7A659	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF31	FRIZZLED-7
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000018202|UniProtKB=E2RPJ2	Mitogen-activated protein kinase	ISS	15085193	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00047	PDGF signaling pathway	P01148	Grb2	CAEEL|WormBase=WBGene00004774|UniProtKB=P29355	Sex muscle abnormal protein 5	ISS	11457149	PubMed	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	TAS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00049	Parkinson disease	P01208	Hsp70	PANTR|Ensembl=ENSPTRG00000029754|UniProtKB=H2R7H0	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF210	HEAT SHOCK 70 KDA PROTEIN 1-LIKE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	TRYB2|Gene=Tb11.01.7800|UniProtKB=Q381H3	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00018	EGF receptor signaling pathway	P00565	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00006	Apoptosis signaling pathway	P00274	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	MACMU|Ensembl=ENSMMUG00000016675|UniProtKB=F6VTB5	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00012	Cadherin signaling pathway	P00464	Fyn	HUMAN|HGNC=4037|UniProtKB=P06241	Tyrosine-protein kinase Fyn	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DANRE|ZFIN=ZDB-GENE-000322-1|UniProtKB=Q9I8V1	Actin, alpha 1, skeletal muscle	IEP	10974003	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00057	Wnt signaling pathway	P01451	Galpha	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00539	14-3-3	ORNAN|Ensembl=ENSOANG00000006084|UniProtKB=F7BU66	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF14	14-3-3 PROTEIN SIGMA
P00004	Alzheimer disease-presenilin pathway	P00111	C99	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00008	Axon guidance mediated by Slit/Robo	P00342	Slit	RAT|RGD=69310|UniProtKB=Q9WVC1	Slit homolog 2 protein (Fragment)	ISS	10432110	PubMed	PTHR24373:SF107	SLIT HOMOLOG 2 PROTEIN
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014262|UniProtKB=F7BYS8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	CAEEL|WormBase=WBGene00002189|UniProtKB=P21137	cAMP-dependent protein kinase catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00020	FAS signaling pathway	P00594	Caspase8	CHICK|Ensembl=ENSGALG00000008355|UniProtKB=F1NXP6	Uncharacterized protein	IGI	11788820	PubMed	PTHR10454:SF162	CASPASE-8
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	RAT|RGD=2732|UniProtKB=P22756	Glutamate receptor ionotropic, kainate 1	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00006	Apoptosis signaling pathway	P00316	Bcl-w	BOVIN|Ensembl=ENSBTAG00000019692|UniProtKB=Q1RMX3	Bcl-2-like protein 2	ISS	8761287	PubMed	PTHR11256:SF13	BCL-2-LIKE PROTEIN 2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008026|UniProtKB=H2QAZ2	Syntaxin 1B	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00019	Endothelin signaling pathway	P00590	IP3 R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-2280|UniProtKB=Q6P025	Gnb3 protein	ISS			PTHR19850:SF35	GNB3 PROTEIN
P00048	PI3 kinase pathway	P01198	FOXO	CANLF|Ensembl=ENSCAFG00000005965|UniProtKB=E2R9H7	Uncharacterized protein	ISS			PTHR11829:SF159	FORKHEAD BOX PROTEIN O1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00049	Parkinson disease	P01227	20S proteasome	ANOGA|EnsemblGenome=AGAP005423|UniProtKB=Q7Q797	Proteasome subunit alpha type	TAS	12859888	PubMed	PTHR11599:SF15	PROTEASOME SUBUNIT ALPHA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	PANTR|Ensembl=ENSPTRG00000015241|UniProtKB=Q5IS72	D(3) dopamine receptor	ISS	2039532	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00012	Cadherin signaling pathway	P00474	Wnt	MONDO|Ensembl=ENSMODG00000015792|UniProtKB=Q2QL96	Protein Wnt-2	ISS	11266476	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00012	Cadherin signaling pathway	P00463	betacatenin	MONDO|Ensembl=ENSMODG00000011192|UniProtKB=F6SRK5	Uncharacterized protein	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P04398	p53 pathway feedback loops 2	P04665	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P02775	Salvage pyrimidine ribonucleotides	P03156	CDP kinase	MONDO|Ensembl=ENSMODG00000001349|UniProtKB=F7FW97	Uridine-cytidine kinase	ISS			PTHR10285:SF70	URIDINE-CYTIDINE KINASE 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01080	AChE	CAEBR|Gene=CBG14965|UniProtKB=A8XL40	Carboxylic ester hydrolase	ISS	86008285	PubMed	PTHR43918:SF6	CARBOXYLIC ESTER HYDROLASE
P00005	Angiogenesis	P00206	Wnt	MOUSE|MGI=MGI=108071|UniProtKB=P70701	Protein Wnt-10a	ISS	8717036	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MACMU|Ensembl=ENSMMUG00000009759|UniProtKB=F6ZIH3	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF504	MYOSIN-13
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00054	Toll receptor signaling pathway	P01355	AP1	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00019	Endothelin signaling pathway	P00566	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	20331588	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00053	T cell activation	P01330	IKK	HUMAN|HGNC=1974|UniProtKB=O15111	Inhibitor of nuclear factor kappa-B kinase subunit alpha	IGI	9346484	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00021	FGF signaling pathway	P00629	PP2A	TAKRU|Ensembl=ENSTRUG00000003840|UniProtKB=H2S9H8	Uncharacterized protein	ISS	11007767	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00552	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12874273	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	TRIAD|EnsemblGenome=TriadG37105|UniProtKB=B3RJX8	Calmodulin	ISS			PTHR23050:SF245	AT16150P-RELATED
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	CANLF|Ensembl=ENSCAFG00000031831|UniProtKB=J9P6R1	Uncharacterized protein	ISS			PTHR10540:SF7	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00005	Angiogenesis	P00193	SOS-1	DICDI|dictyBase=DDB_G0274605|UniProtKB=Q8SSQ0	Ras guanine nucleotide exchange factor R	ISS			PTHR23113:SF162	RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR R
P00036	Interleukin signaling pathway	P00971	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8051109	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P02738	De novo purine biosynthesis	P02894	IMP cyclohydrolase	DICDI|dictyBase=DDB_G0277087|UniProtKB=Q86L14	Bifunctional purine biosynthesis protein purH	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	CANLF|Ensembl=ENSCAFG00000015213|UniProtKB=E2RB82	Signal transducer and activator of transcription	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00045	Notch signaling pathway	G01541	E(spl)-C genes	MACMU|Ensembl=ENSMMUG00000001817|UniProtKB=F7GS86	Uncharacterized protein	ISS	14973298	PubMed	PTHR10985:SF125	TRANSCRIPTION FACTOR HES-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CAEEL|WormBase=WBGene00018569|UniProtKB=Q7JP68	cAMP-dependent protein kinase, catalytic subunit-like	ISS	1319556	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00029	Huntington disease	P00807	Actin	MOUSE|MGI=MGI=87902|UniProtKB=P68134	Actin, alpha skeletal muscle	ISS	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MOUSE|MGI=MGI=109248|UniProtKB=Q920H4	Muscarinic acetylcholine receptor M5	TAS	12181435	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00052	TGF-beta signaling pathway	P01284	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEEL|WormBase=WBGene00018620|UniProtKB=O44588	Uncharacterized protein	ISS	11880265	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	MACMU|Ensembl=ENSMMUG00000001498|UniProtKB=F7B5K3	Uncharacterized protein	ISS	12844405	PubMed	PTHR11644:SF2	CYTIDINE DEAMINASE
P05731	GABA-B receptor II signaling	P05755	Gbeta	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00019	Endothelin signaling pathway	P00572	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00036	Interleukin signaling pathway	P00995	c-Myc	CHICK|Ensembl=ENSGALG00000016308|UniProtKB=P01109	Myc proto-oncogene protein	ISS	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00059	p53 pathway	P04634	Cdc2	CHICK|Gene=CDK1|UniProtKB=P13863	Cyclin-dependent kinase 1	ISS			PTHR24056:SF334	CYCLIN-DEPENDENT KINASE 1
P00047	PDGF signaling pathway	P01171	PLCgamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00005	Angiogenesis	P00245	Rac	MACMU|Ensembl=ENSMMUG00000005364|UniProtKB=F6Y674	Proline-rich protein 5 isoform 1	ISS			PTHR32428:SF4	PROLINE-RICH PROTEIN 5
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	RAT|RGD=628873|UniProtKB=Q6P6R0	Protein lifeguard 1	ISS			PTHR23291:SF16	PROTEIN LIFEGUARD 1
P00059	p53 pathway	P01485	p53	DANRE|ZFIN=ZDB-GENE-030819-1|UniProtKB=E9QG65	Uncharacterized protein	TAS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00036	Interleukin signaling pathway	P00965	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00036	Interleukin signaling pathway	P00990	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00706	RGS-PX1	CANLF|Ensembl=ENSCAFG00000002467|UniProtKB=F1PSY8	Uncharacterized protein	ISS	11729322	PubMed	PTHR22775:SF30	SORTING NEXIN-13
P00036	Interleukin signaling pathway	P00977	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00048	PI3 kinase pathway	P01178	Grb2	CAEBR|Gene=CBG16856|UniProtKB=A8XPY6	Protein CBR-SEM-5	ISS	51702266	gi	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00047	PDGF signaling pathway	P01154	Ras	CANAL|EnsemblGenome=CaO19.1760|UniProtKB=Q59XU5	Ras-like protein 1	ISS	99445463	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01452	NFAT	HUMAN|HGNC=7776|UniProtKB=Q13469	Nuclear factor of activated T-cells, cytoplasmic 2	IDA	9462517	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DAPPU|EnsemblGenome=DAPPUDRAFT_59367|UniProtKB=E9H7Z0	Guanine nucleotide-binding protein G(O) subunit alpha 1	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P05730	Endogenous cannabinoid signaling	P05751	Galpha	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	8170357	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=18539|UniProtKB=P61266	Syntaxin-1B	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P05730	Endogenous cannabinoid signaling	P05751	Galpha	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00562	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00053	T cell activation	P01315	Calcineurin	MOUSE|MGI=MGI=107162|UniProtKB=P48455	Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform	IGI	12091710	PubMed	PTHR11668:SF186	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT GAMMA ISOFORM
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	CANLF|Ensembl=ENSCAFG00000005449|UniProtKB=F1PNA9	TGF-beta receptor type-2	ISS	9759503	PubMed	PTHR23255:SF55	TGF-BETA RECEPTOR TYPE-2
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	HUMAN|HGNC=4596|UniProtKB=Q14833	Metabotropic glutamate receptor 4	IC	9407094	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00056	VEGF signaling pathway	P01411	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	RCA	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IGI	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00010	B cell activation	P00379	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00060	Ubiquitin proteasome pathway	P01492	E1	PANTR|Ensembl=ENSPTRG00000014936|UniProtKB=H2QMM5	Uncharacterized protein	ISS			PTHR10953:SF143	UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 7
P04393	Ras Pathway	P04546	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	IDA	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	HUMAN|HGNC=7881|UniProtKB=P46531	Neurogenic locus notch homolog protein 1	IDA	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00029	Huntington disease	P00796	Kainate receptor	RAT|RGD=2734|UniProtKB=Q01812	Glutamate receptor ionotropic, kainate 4	IDA	11319238	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00005	Angiogenesis	P00182	p38MAPK	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	HUMAN|HGNC=10626|UniProtKB=Q9Y4X3	C-C motif chemokine 27	IDA	11821900	PubMed	PTHR17502:SF4	C-C MOTIF CHEMOKINE 27
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	SCHMA|EnsemblGenome=Smp_183710|UniProtKB=G4VLW1	Putative actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MACMU|Ensembl=ENSMMUG00000016675|UniProtKB=F6VTB5	Uncharacterized protein	ISS	14698601	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	RAT|RGD=3425|UniProtKB=P97887	Presenilin-1	IDA	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P05918	p38 MAPK pathway	P06043	ASK1	MACMU|Ensembl=ENSMMUG00000016376|UniProtKB=F7G2W1	Uncharacterized protein	ISS	12697749	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00973	PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00034	Integrin signalling pathway	P00913	Csk	RAT|RGD=1308800|UniProtKB=P32577	Tyrosine-protein kinase CSK	IDA	11078745	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00925	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04396	Vitamin D metabolism and pathway	P04601	25-Hydroxylase	HUMAN|HGNC=2606|UniProtKB=O15528	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	ISS	11013342	PubMed	PTHR24291:SF3	25-HYDROXYVITAMIN D-1 ALPHA HYDROXYLASE, MITOCHONDRIAL
P00049	Parkinson disease	P01219	SAPK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	NAS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00060	Ubiquitin proteasome pathway	P01490	E3	PANTR|Ensembl=ENSPTRG00000019444|UniProtKB=H2R545	Uncharacterized protein	ISS	11252892	PubMed	PTHR11254:SF293	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	HUMAN|HGNC=706|UniProtKB=O15145	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	DROME|FlyBase=FBgn0001991|UniProtKB=Q24270	Voltage-dependent calcium channel type D subunit alpha-1	ISS	9199552	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00029	Huntington disease	P00790	beta-Tubulin	CHICK|GeneID=396254|UniProtKB=P09244	Tubulin beta-7 chain	TAS	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00010	B cell activation	P00376	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IDA	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P04398	p53 pathway feedback loops 2	P04651	Ras	ANOGA|EnsemblGenome=AGAP002219|UniProtKB=Q7QK91	AGAP002219-PA	IDA	10684567	PubMed	PTHR24070:SF385	GTPASE HRAS
P00005	Angiogenesis	P00200	Dsh	CHICK|Ensembl=ENSGALG00000008414|UniProtKB=F1P5N3	Uncharacterized protein	ISS	10409711	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00053	T cell activation	P01306	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	RCA	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	BOVIN|Ensembl=ENSBTAG00000020983|UniProtKB=Q2TBH2	Related RAS viral (R-ras) oncogene homolog	ISS	7997267	PubMed	PTHR24070:SF245	RAS-RELATED PROTEIN R-RAS
P05915	Opioid proenkephalin pathway	P05994	G-protein	ANOGA|EnsemblGenome=AGAP005911|UniProtKB=Q7Q6D4	AGAP005911-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00059	p53 pathway	G01575	GADD45	HUMAN|HGNC=4096|UniProtKB=O75293	Growth arrest and DNA damage-inducible protein GADD45 beta	IGI	10097101	PubMed	PTHR10411:SF5	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 BETA
P05731	GABA-B receptor II signaling	P05755	Gbeta	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=97439|UniProtKB=P33534	Kappa-type opioid receptor	IDA	11259487	PubMed	PTHR24229:SF1	KAPPA-TYPE OPIOID RECEPTOR
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	91056091	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	CANLF|Ensembl=ENSCAFG00000018144|UniProtKB=F1PNI3	Uncharacterized protein	ISS	84261525	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00029	Huntington disease	P00790	beta-Tubulin	CAEEL|WormBase=WBGene00006539|UniProtKB=G5EF01	TuBulin, Beta	TAS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00048	PI3 kinase pathway	P01188	Gbetagamma	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00036	Interleukin signaling pathway	P00973	PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00021	FGF signaling pathway	P00648	PKC	CANAL|CGD=CAL0003231|UniProtKB=Q5ANK2	Protein kinase C	IGI	8813761	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00249	PAK	BOVIN|Ensembl=ENSBTAG00000015670|UniProtKB=E1B7J7	Uncharacterized protein	ISS	11259591	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P05913	Enkephalin release	P05977	G-Protein (s)	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00036	Interleukin signaling pathway	P00986	eNOS	PANTR|Ensembl=ENSPTRG00000019868|UniProtKB=H2QVM2	Nitric oxide synthase	ISS	9837777	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P04393	Ras Pathway	P04541	p90RSK	ORNAN|Ensembl=ENSOANG00000010658|UniProtKB=F6V2V1	Uncharacterized protein	ISS	2779569	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00053	T cell activation	P01324	rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00006	Apoptosis signaling pathway	P00291	MEKK1	BOVIN|Ensembl=ENSBTAG00000013790|UniProtKB=E1B847	Uncharacterized protein	ISS	8940199	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	USTMA|Gene=UMAG_03910|UniProtKB=A0A0D1DU81	Chromosome 11, whole genome shotgun sequence	ISS	3885394	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00047	PDGF signaling pathway	P01154	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00021	FGF signaling pathway	P00648	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00021	FGF signaling pathway	P00632	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00645	Rac	DICPU|Gene=DICPUDRAFT_92985|UniProtKB=F1A084	Putative uncharacterized protein rac1A	ISS	8649368	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00057	Wnt signaling pathway	P01437	TCF	MOUSE|MGI=MGI=1202876|UniProtKB=Q9Z1J1	Transcription factor 7-like 1	IDA	12356903	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00036	Interleukin signaling pathway	P00987	SRF	MACMU|Ensembl=ENSMMUG00000000033|UniProtKB=F7G4D2	Uncharacterized protein	ISS	15647354	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00056	VEGF signaling pathway	P01413	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	12660731	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	IDA	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00059	p53 pathway	P04630	PP2A	CHICK|Ensembl=ENSGALG00000010273|UniProtKB=P48463	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	2461222	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04398	p53 pathway feedback loops 2	P04664	cyclin E	CHICK|Gene=CCNE1|UniProtKB=P49707	G1/S-specific cyclin-E1	NAS	12628165	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00029	Huntington disease	P00802	PACSIN-1	MOUSE|MGI=MGI=1345181|UniProtKB=Q61644	Protein kinase C and casein kinase substrate in neurons protein 1	IDA	12354780	PubMed	PTHR23065:SF16	PROTEIN KINASE C AND CASEIN KINASE SUBSTRATE IN NEURONS PROTEIN 1
P06587	Nicotine pharmacodynamics pathway	P06594	CHRNA4	MACMU|Ensembl=ENSMMUG00000015916|UniProtKB=F7AT89	Uncharacterized protein	ISS	17597586	PubMed	PTHR18945:SF401	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4
P00047	PDGF signaling pathway	P01169	Vav	HUMAN|HGNC=12659|UniProtKB=Q9UKW4	Guanine nucleotide exchange factor VAV3	ISS	14623913	PubMed	PTHR22826:SF97	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00005	Angiogenesis	P00203	Erk	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02756	N-acetylglucosamine metabolism	P03040	N-acetylneuraminate lyase	HUMAN|HGNC=16781|UniProtKB=Q9BXD5	N-acetylneuraminate lyase	ISS			PTHR12128:SF21	N-ACETYLNEURAMINATE LYASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01465	Ggamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	ORNAN|Ensembl=ENSOANG00000008907|UniProtKB=F7EDR2	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CAEEL|WormBase=WBGene00015478|UniProtKB=Q11179	Putative serine/threonine-protein kinase C05D10.2	IDA	12787066	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00053	T cell activation	P01332	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00243	Raf	MOUSE|MGI=MGI=88190|UniProtKB=P28028	Serine/threonine-protein kinase B-raf	ISS	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00048	PI3 kinase pathway	P01198	FOXO	CANLF|Ensembl=ENSCAFG00000016925|UniProtKB=E2RTA1	Uncharacterized protein	ISS			PTHR11829:SF188	FORKHEAD BOX PROTEIN O4
P00021	FGF signaling pathway	P00625	MKK3,6	MONDO|Ensembl=ENSMODG00000001404|UniProtKB=F7BD74	Uncharacterized protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05913	Enkephalin release	G06045	preproenkephalin	XENTR|Xenbase=XB-GENE-942760|UniProtKB=F6Y5F6	Uncharacterized protein	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00020	FAS signaling pathway	P00615	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00021	FGF signaling pathway	P00644	p38	DANRE|ZFIN=ZDB-GENE-990415-257|UniProtKB=O42376	Mitogen-activated protein kinase 12	ISS	11274345	PubMed	PTHR24055:SF339	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00054	Toll receptor signaling pathway	P01368	MKK2	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P02787	Vitamin B6 metabolism	P03244	Pyridoxal kinase	HUMAN|HGNC=8819|UniProtKB=O00764	Pyridoxal kinase	IDA	9099727	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P00018	EGF receptor signaling pathway	P00550	Grb2	CAEEL|WormBase=WBGene00004774|UniProtKB=P29355	Sex muscle abnormal protein 5	IGI	17569445	gi	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Ensembl=ENSPTRG00000016548|UniProtKB=H2QQC5	Uncharacterized protein	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00011	Blood coagulation	P00429	PN2	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	ISS	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05731	GABA-B receptor II signaling	P05755	Gbeta	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P02727	Androgen/estrogene/progesterone biosynthesis	P02826	Estradiol 17beta-dehydrogenase	MOUSE|MGI=MGI=1351670|UniProtKB=Q9R092	17-beta-hydroxysteroid dehydrogenase type 6	RCA			PTHR43313:SF4	17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 6
P00059	p53 pathway	P04609	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	BOVIN|Ensembl=ENSBTAG00000006143|UniProtKB=E1BNX4	Uncharacterized protein	ISS	123810	OMIM	PTHR22952:SF24	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 1
P00021	FGF signaling pathway	P00640	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IGI	7565716	PubMed	PTHR10048:SF14	PI-3 KINASE
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-2280|UniProtKB=Q6P025	Gnb3 protein	ISS			PTHR19850:SF35	GNB3 PROTEIN
P00018	EGF receptor signaling pathway	P00564	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	PANTR|Ensembl=ENSPTRG00000017730|UniProtKB=H2QSB1	Uncharacterized protein	ISS	15117818	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00057	Wnt signaling pathway	P01438	PP2A	MOUSE|MGI=MGI=2388481|UniProtKB=Q91V89	Protein Ppp2r5d	ISS	96161994	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06006	beta-Endorphin	DANRE|ZFIN=ZDB-GENE-030513-2|UniProtKB=Q7ZT18	Pro-opiomelanocortin protein	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P04393	Ras Pathway	P04559	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12676940	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00048	PI3 kinase pathway	P01181	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	YEAST|SGD=S000005854|UniProtKB=P33328	Synaptobrevin homolog 2	IC			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	MOUSE|MGI=MGI=109355|UniProtKB=O35526	Syntaxin-1A	ISS	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00024	Glycolysis	P00671	Phosphoglycerate kinase	TETTS|EnsemblGenome=TTHERM_00929450|UniProtKB=Q24CJ7	Phosphoglycerate kinase	ISS	92292176	PubMed	PTHR11406:SF0	PHOSPHOGLYCERATE KINASE
P00046	Oxidative stress response	P01126	ATF2	BOVIN|Ensembl=ENSBTAG00000002295|UniProtKB=F1N177	Uncharacterized protein	ISS	10664585	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00892	Grb2	DANRE|ZFIN=ZDB-GENE-040426-1975|UniProtKB=Q6PC73	Growth factor receptor-bound protein 2	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00019	Endothelin signaling pathway	P00590	IP3 R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00023	General transcription regulation	P00666	TFIIE	PANTR|Ensembl=ENSPTRG00000015273|UniProtKB=H2QN66	General transcription factor IIE, polypeptide 1, alpha 56kDa	ISS	189962	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00059	p53 pathway	G04699	BAI-1	MOUSE|MGI=MGI=1933736|UniProtKB=Q3UHD1	Brain-specific angiogenesis inhibitor 1	IGI	9393972	PubMed	PTHR12011:SF39	BRAIN-SPECIFIC ANGIOGENESIS INHIBITOR 1
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00030	Hypoxia response via HIF activation	P00819	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	TAS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	CANLF|Ensembl=ENSCAFG00000015662|UniProtKB=E2RHY4	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P02762	Pentose phosphate pathway	P03080	Glucose-P-Isomerase	BOVIN|Ensembl=ENSBTAG00000006396|UniProtKB=Q3ZBD7	Glucose-6-phosphate isomerase	ISS	2248981	PubMed	PTHR11469:SF4	GLUCOSE-6-PHOSPHATE ISOMERASE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00057	Wnt signaling pathway	P01451	Galpha	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	BOVIN|Ensembl=ENSBTAG00000014828|UniProtKB=F1N1E0	Uncharacterized protein	ISS	14507926	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	BOVIN|Ensembl=ENSBTAG00000018445|UniProtKB=E1BK87	Uncharacterized protein	ISS	14698601	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00048	PI3 kinase pathway	P01192	p110	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	PSEAE|EnsemblGenome=PA2040|UniProtKB=Q9I275	Probable glutamine synthetase	ISS			PTHR43785:SF1	TYPE-1 GLUTAMINE SYNTHETASE 2
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	89107990	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=12776|UniProtKB=O96014	Protein Wnt-11	TAS	11266476	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P04398	p53 pathway feedback loops 2	P04657	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ORYSJ|EnsemblGenome=OS10G0510000|UniProtKB=A3C6D7	Actin-2	ISS	10974003	PubMed	PTHR11937:SF252	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	IDA	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P02763	Peptidoglycan biosynthesis	P03090	N-Acetylglucosaminyl transferase	BACSU|EnsemblGenome=BSU21920|UniProtKB=P54166	Processive diacylglycerol beta-glucosyltransferase	ISS			PTHR43025:SF4	SUBFAMILY NOT NAMED
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	CAEEL|WormBase=WBGene00001680|UniProtKB=Q20636	Guanine nucleotide-binding protein subunit beta-2	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00030	Hypoxia response via HIF activation	P00819	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	DANRE|ZFIN=ZDB-GENE-040718-93|UniProtKB=Q6DGZ5	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00591	PLCbeta	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05913	Enkephalin release	P05971	CREB	BOVIN|Gene=CREB1|UniProtKB=P27925	Cyclic AMP-responsive element-binding protein 1	ISS	11752053	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00059	p53 pathway	P04623	CBP	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	IDA	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00057	Wnt signaling pathway	P01465	Ggamma	MOUSE|MGI=MGI=102705|UniProtKB=P63213	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IDA	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IGI	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	MACMU|Ensembl=ENSMMUG00000028962|UniProtKB=F7EWG5	Uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF322	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Gene=HTR1F|UniProtKB=Q9N2D9	5-hydroxytryptamine receptor 1F (Fragment)	IDA	12441358	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00036	Interleukin signaling pathway	P00962	ELK	CHICK|Ensembl=ENSGALG00000011435|UniProtKB=Q5ZMM7	Uncharacterized protein	ISS			PTHR11849:SF172	ETS DOMAIN-CONTAINING PROTEIN ELK-3
P00018	EGF receptor signaling pathway	P00565	PKC	SCHPO|PomBase=SPBC12D12.04c|UniProtKB=P36583	Protein kinase C-like 2	IGI	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	TAS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05916	Opioid prodynorphin pathway	P05999	provasopressin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P06959	CCKR signaling map	G07262	HDC	HUMAN|HGNC=4855|UniProtKB=P19113	Histidine decarboxylase	RCA	10409643	PubMed	PTHR11999:SF68	HISTIDINE DECARBOXYLASE
P00009	Axon guidance mediated by netrin	P00363	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g242065|UniProtKB=A7S0V7	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	ORNAN|Ensembl=ENSOANG00000007732|UniProtKB=F6PXH5	Uncharacterized protein (Fragment)	ISS	97059154	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04397	p53 pathway by glucose deprivation	P04641	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01329	CD45	RAT|RGD=3451|UniProtKB=P04157	Receptor-type tyrosine-protein phosphatase C	IGI	1672451	PubMed	PTHR19134:SF284	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C
P00055	Transcription regulation by bZIP transcription factor	P01398	TFIIEalpha	HUMAN|HGNC=4650|UniProtKB=P29083	General transcription factor IIE subunit 1	IGI	92065982	PubMed	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00006	Apoptosis signaling pathway	P00321	HSP70	PHYPA|Gene=PHYPADRAFT_226216|UniProtKB=A9TWR9	Predicted protein	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00048	PI3 kinase pathway	P01192	p110	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00931	Integrin beta	BOVIN|Gene=ITGB5|UniProtKB=P80747	Integrin beta-5	IDA	3487386	PubMed	PTHR10082:SF26	INTEGRIN BETA-5
P00057	Wnt signaling pathway	P01438	PP2A	RAT|RGD=3381|UniProtKB=P62716	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CHICK|Ensembl=ENSGALG00000014620|UniProtKB=F1N8P3	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00047	PDGF signaling pathway	P01150	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	HUMAN|HGNC=1388|UniProtKB=O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	8386525	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00019	Endothelin signaling pathway	P00589	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00009	Axon guidance mediated by netrin	P00366	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00035	Interferon-gamma signaling pathway	P00956	SOCS	BOVIN|Ensembl=ENSBTAG00000021988|UniProtKB=Q0VC91	Suppressor of cytokine signaling 4	ISS	15032587	PubMed	PTHR44282:SF2	SUPPRESSOR OF CYTOKINE SIGNALING 4
P00005	Angiogenesis	P00219	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	PANTR|Ensembl=ENSPTRG00000017278|UniProtKB=H2QRJ8	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P00025	Hedgehog signaling pathway	P00688	Hedgehog	DROME|FlyBase=FBgn0004644|UniProtKB=Q02936	Protein hedgehog	IDA	8287482	PubMed	PTHR11889:SF31	PROTEIN HEDGEHOG
P00057	Wnt signaling pathway	P01472	Histone deacetylase	MOUSE|MGI=MGI=108086|UniProtKB=O09106	Histone deacetylase 1	IDA	10485845	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	RAT|RGD=2025|UniProtKB=P68136	Actin, alpha skeletal muscle	ISS	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	RCA			PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00021	FGF signaling pathway	P00627	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P02723	Adenine and hypoxanthine salvage pathway	P02812	Deoxyinosine phosphorylase	SCHPO|PomBase=SPAC1805.16c|UniProtKB=Q9UTG1	Putative purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	15210700	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00008	Axon guidance mediated by Slit/Robo	P00344	Netrin	CANLF|Ensembl=ENSCAFG00000019366|UniProtKB=E2R3Q6	Uncharacterized protein	ISS			PTHR10574:SF292	NETRIN-3
P00029	Huntington disease	P00775	Rac	DICDI|dictyBase=DDB_G0293526|UniProtKB=P34149	Rho-related protein racC	TAS			PTHR24072:SF117	RHO-RELATED PROTEIN RACC
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00054	Toll receptor signaling pathway	P01375	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00021	FGF signaling pathway	P00629	PP2A	DANRE|ZFIN=ZDB-GENE-030904-7|UniProtKB=Q8AXX6	Ppp2r5e2 protein	ISS	8703017	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05730	Endogenous cannabinoid signaling	P05743	CB1	RAT|RGD=2369|UniProtKB=P20272	Cannabinoid receptor 1	IDA	2165569	PubMed	PTHR22750:SF47	CANNABINOID RECEPTOR 1
P04393	Ras Pathway	P04566	Stat 1/3	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	15825084	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	HUMAN|HGNC=5286|UniProtKB=P08908	5-hydroxytryptamine receptor 1A	IDA			PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	RAT|RGD=1307277|UniProtKB=D3ZSB7	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF41	RIBOSOMAL PROTEIN S6 KINASE ALPHA-4
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MONDO|Ensembl=ENSMODG00000015246|UniProtKB=F6UJF5	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00634	MEKK1-5	PANTR|Ensembl=ENSPTRG00000016891|UniProtKB=H2R5K3	Uncharacterized protein	ISS	12049732	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00015	Circadian clock system	P00506	BMAL1	BOVIN|Ensembl=ENSBTAG00000013029|UniProtKB=E1BLF5	Uncharacterized protein	ISS	11163178	PubMed	PTHR23042:SF52	ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 1
P00005	Angiogenesis	P00206	Wnt	MOUSE|MGI=MGI=98954|UniProtKB=P21552	Protein Wnt-2	ISS	8717036	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00049	Parkinson disease	P01215	Syntaxin	CANLF|Ensembl=ENSCAFG00000000185|UniProtKB=E2R4Q2	Uncharacterized protein	ISS	14570579	PubMed	PTHR19957:SF90	SYNTAXIN-7
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	CHICK|Ensembl=ENSGALG00000007871|UniProtKB=F1NL65	Uncharacterized protein	ISS	94365697	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P05731	GABA-B receptor II signaling	P05754	Ggamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00029	Huntington disease	P00780	Microtubule	ARATH|TAIR=AT5G44340|UniProtKB=P24636	Tubulin beta-4 chain	IDA	9454836	PubMed	PTHR11588:SF245	TUBULIN BETA-4 CHAIN-RELATED
P00020	FAS signaling pathway	P00620	CytochromeC	DROME|FlyBase=FBgn0039651|UniProtKB=Q9VAM8	AT13706p	ISS	15163634	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	RAT|RGD=2847|UniProtKB=P28565	5-hydroxytryptamine receptor 1D	IEA	12441358	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00036	Interleukin signaling pathway	P00968	Ikk	MACMU|Ensembl=ENSMMUG00000008351|UniProtKB=F7HRV5	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	NEUCR|EnsemblGenome=EFNCRG00000003813|UniProtKB=Q1K7I3	Extracellular developmental signal biosynthesis protein FluG	ISS			PTHR43785:SF2	TYPE-1 GLUTAMINE SYNTHETASE 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	ISS	91298951	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01275	P38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00049	Parkinson disease	P01242	Casein kinase I	PANTR|Ensembl=ENSPTRG00000009796|UniProtKB=H2QE47	Casein kinase 1, delta	ISS	11437445	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04558	p38	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00021	FGF signaling pathway	P00627	ERK1-2	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MOUSE|MGI=MGI=1096327|UniProtKB=O35625	Axin-1	ISS	9554852	PubMed	PTHR10845:SF11	AXIN-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MOUSE|MGI=MGI=1351342|UniProtKB=Q3UVX5	Metabotropic glutamate receptor 5	ISS	14614461	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00021	FGF signaling pathway	P00625	MKK3,6	CHICK|Ensembl=ENSGALG00000004735|UniProtKB=F1NHE1	Uncharacterized protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00015	Circadian clock system	P00505	Cry	ORNAN|Ensembl=ENSOANG00000005350|UniProtKB=F6X852	Uncharacterized protein	ISS	14507900	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=3972|UniProtKB=Q12841	Follistatin-related protein 1	ISS	8717036	PubMed	PTHR10913:SF13	FOLLISTATIN-RELATED PROTEIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	BOVIN|Ensembl=ENSBTAG00000018445|UniProtKB=E1BK87	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9060|UniProtKB=P51178	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	12860966	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00015	Circadian clock system	G01504	bmal1	CHICK|Ensembl=ENSGALG00000005378|UniProtKB=Q9I8T7	Aryl hydrocarbon receptor nuclear translocator-like protein 1	ISS	11163178	PubMed	PTHR23042:SF52	ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 1
P02788	Xanthine and guanine salvage pathway	P03245	Guanine phosphoribosyl transferase	CHICK|Gene=HPRT1|UniProtKB=Q9W719	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF6	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE
P00034	Integrin signalling pathway	P00925	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IDA	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MACMU|Ensembl=ENSMMUG00000001458|UniProtKB=F7BKH1	Uncharacterized protein	ISS	12932731	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00029	Huntington disease	P00790	beta-Tubulin	HUMAN|HGNC=20776|UniProtKB=Q9BUF5	Tubulin beta-6 chain	TAS	9454836	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TRIVA|Gene=TVAG_512800|UniProtKB=A2HNG1	Actin (Fragment)	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00029	Huntington disease	P00807	Actin	ORNAN|Ensembl=ENSOANG00000000460|UniProtKB=F7F4W9	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00029	Huntington disease	P00781	Dynactin	PANTR|Ensembl=ENSPTRG00000030450|UniProtKB=H2QI59	Uncharacterized protein	ISS	9454836	PubMed	PTHR18916:SF40	DYNACTIN SUBUNIT 1
P00005	Angiogenesis	P00183	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	10982827	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00056	VEGF signaling pathway	P01407	Erk	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00564	Rac	DICDI|dictyBase=DDB_G0279605|UniProtKB=P34148	Rho-related protein racB	IGI	12932731	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	YEAST|SGD=S000006125|UniProtKB=P29295	Casein kinase I homolog HRR25	IDA	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	HUMAN|HGNC=1954|UniProtKB=P08912	Muscarinic acetylcholine receptor M5	IDA	8100450	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CAEEL|WormBase=WBGene00013168|UniProtKB=Q9NA98	Actin-Related Proteins	IC	14684598	PubMed	PTHR11937:SF46	ALPHA-CENTRACTIN
P00012	Cadherin signaling pathway	P00474	Wnt	TAKRU|Ensembl=ENSTRUG00000011280|UniProtKB=H2TUW3	Protein Wnt	IDA	11266476	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00057	Wnt signaling pathway	P01465	Ggamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	BOVIN|Ensembl=ENSBTAG00000004624|UniProtKB=E1B953	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00006	Apoptosis signaling pathway	P00274	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DROME|FlyBase=FBgn0000042|UniProtKB=P10987	Actin-5C	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00054	Toll receptor signaling pathway	P01370	TAK1	PANTR|Ensembl=ENSPTRG00000018427|UniProtKB=H2RCY2	Mitogen-activated protein kinase kinase kinase 7	ISS	10683140	PubMed	PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	IC	10477300	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00632	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01444	Wnt	PANTR|Ensembl=ENSPTRG00000004893|UniProtKB=H2Q5U4	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	RAT|RGD=3694|UniProtKB=Q01827	Synaptic vesicular amine transporter	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CAEBR|Gene=CBG02161|UniProtKB=A8WS32	Protein CBG02161	ISS	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00052	TGF-beta signaling pathway	P01292	RSmads	XENTR|Xenbase=XB-GENE-484686|UniProtKB=Q6DIZ6	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF41	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 9
P04372	5-Hydroxytryptamine degredation	P04401	Monoamine Oxidase	MACMU|Ensembl=ENSMMUG00000019492|UniProtKB=F7D3H3	Amine oxidase [flavin-containing]	ISS	90344230	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	ARATH|TAIR=AT1G57870|UniProtKB=Q9FVS6	Shaggy-related protein kinase delta	TAS			PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00059	p53 pathway	P04628	14-3-3	MACMU|Ensembl=ENSMMUG00000013855|UniProtKB=F6RM85	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF14	14-3-3 PROTEIN SIGMA
P04398	p53 pathway feedback loops 2	P04668	p53	HUMAN|HGNC=15979|UniProtKB=Q9H3D4	Tumor protein 63	TAS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00005	Angiogenesis	P00206	Wnt	CANLF|Ensembl=ENSCAFG00000029321|UniProtKB=J9P5H0	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00005	Angiogenesis	P00203	Erk	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	ISS	14526383	PubMed	PTHR10048:SF14	PI-3 KINASE
P00022	General transcription by RNA polymerase I	P00657	TBP	DROME|FlyBase=FBgn0010287|UniProtKB=Q27896	TBP-related factor	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MACMU|Ensembl=ENSMMUG00000011912|UniProtKB=F7HMT9	Bone morphogenetic protein 3	ISS	9759503	PubMed	PTHR11848:SF145	GROWTH/DIFFERENTIATION FACTOR 10
P00010	B cell activation	P00376	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P02738	De novo purine biosynthesis	P02902	ADP reductase	DROME|FlyBase=FBgn0011703|UniProtKB=P48591	Ribonucleoside-diphosphate reductase large subunit	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00036	Interleukin signaling pathway	P00996	STAT	TAKRU|Ensembl=ENSTRUG00000015454|UniProtKB=H2URF8	Signal transducer and activator of transcription	ISS			PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000005792|UniProtKB=F6VTR8	Uncharacterized protein	ISS	129387	gi	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P05918	p38 MAPK pathway	P06015	p38gamma	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00012	Cadherin signaling pathway	P00477	GSK3beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DICDI|dictyBase=DDB_G0289489|UniProtKB=P07828	Actin-18	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00029	Huntington disease	P00807	Actin	TAKRU|Ensembl=ENSTRUG00000004787|UniProtKB=P53480	Actin, alpha cardiac	IDA	11889139	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	RAT|RGD=69250|UniProtKB=Q9QXQ7	Protein Wnt-5a	TAS	11266476	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00036	Interleukin signaling pathway	P00965	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IC	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	15860573	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	RCA			PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00053	T cell activation	P01311	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	XENTR|Xenbase=XB-GENE-6067221|UniProtKB=F6Z0J4	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05943	GRK2	PANTR|Ensembl=ENSPTRG00000003946|UniProtKB=H2Q482	Protein-serine/threonine kinase	ISS	10852916	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P00012	Cadherin signaling pathway	P00473	P120	HUMAN|HGNC=2515|UniProtKB=O60716	Catenin delta-1	ISS			PTHR10372:SF6	CATENIN DELTA-1
P00005	Angiogenesis	P00223	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	CAEEL|WormBase=WBGene00022455|UniProtKB=Q9N588	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	TETTS|EnsemblGenome=TTHERM_00630500|UniProtKB=Q241P0	Calmodulin 1	ISS	9753452	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02736	Coenzyme A biosynthesis	P02885	Pantothenate kinase	MACMU|Ensembl=ENSMMUG00000010780|UniProtKB=F7GUZ3	Uncharacterized protein	ISS			PTHR12280:SF23	PANTOTHENATE KINASE 1
P00021	FGF signaling pathway	P00642	MEK1-2	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00048	PI3 kinase pathway	P01188	Gbetagamma	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00025	Hedgehog signaling pathway	P00692	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	P00562	p38	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	IGI	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CAEBR|Gene=CBG05858|UniProtKB=A8X1H0	Protein CBR-EGL-19 (Fragment)	ISS	15621031	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	DROME|FlyBase=FBgn0002842|UniProtKB=Q9VP40	Spermatocyte arrest	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00059	p53 pathway	P01480	PTEN	ARATH|TAIR=AT3G19420|UniProtKB=Q9LT75	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN2A	ISS			PTHR12305:SF32	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE TPTE2-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000002775|UniProtKB=H2RB55	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P05913	Enkephalin release	P05972	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00546	GAP	HUMAN|HGNC=9871|UniProtKB=P20936	Ras GTPase-activating protein 1	IGI	8270251	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05913	Enkephalin release	P05974	G-Protein (i)	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00590	IP3 R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04397	p53 pathway by glucose deprivation	P04641	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00585	ECE1-3	MACMU|Ensembl=ENSMMUG00000010942|UniProtKB=F7GIX6	Uncharacterized protein	ISS	12464614	PubMed	PTHR11733:SF130	ENDOTHELIN-CONVERTING ENZYME 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	BOVIN|Ensembl=ENSBTAG00000006489|UniProtKB=F1MHT3	Uncharacterized protein	ISS			PTHR13140:SF273	UNCONVENTIONAL MYOSIN-VA
P00017	DNA replication	P00527	Histones	ARATH|TAIR=AT5G65350|UniProtKB=Q9FKQ3	Histone H3-like 5	ISS	20448842	PubMed	PTHR11426:SF172	HISTONE H3-LIKE 5-RELATED
P00006	Apoptosis signaling pathway	P00302	ATF	MACMU|Ensembl=ENSMMUG00000002797|UniProtKB=F7AVE1	Uncharacterized protein	ISS			PTHR23351:SF10	JUN DIMERIZATION PROTEIN 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04451	CRHR1	BOVIN|Ensembl=ENSBTAG00000002749|UniProtKB=F1MCX2	Uncharacterized protein	ISS	11145609	PubMed	PTHR12011:SF175	CORTICOTROPIN-RELEASING FACTOR RECEPTOR 1
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00018	EGF receptor signaling pathway	P00552	Ras	CAEBR|Gene=CBG06092|UniProtKB=A8X0X5	Protein CBR-LET-60	ISS	22022015	PubMed	PTHR24070:SF385	GTPASE HRAS
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	HUMAN|HGNC=16767|UniProtKB=Q8TCU5	Glutamate receptor ionotropic, NMDA 3A	ISS	14698601	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	DICDI|dictyBase=DDB_G0275447|UniProtKB=P34109	Myosin ID heavy chain	IC			PTHR13140:SF513	MYOSIN ID HEAVY CHAIN
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00006	Apoptosis signaling pathway	P00269	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01173	STAT	HUMAN|HGNC=11362|UniProtKB=P42224	Signal transducer and activator of transcription 1-alpha/beta	ISS	15825084	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	HUMAN|HGNC=7883|UniProtKB=Q9UM47	Neurogenic locus notch homolog protein 3	IDA	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	IDA	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00053	T cell activation	P01311	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P02738	De novo purine biosynthesis	P02907	dADP kinase	BOVIN|Ensembl=ENSBTAG00000002689|UniProtKB=Q5E9Y9	Nucleoside diphosphate kinase 7	ISS			PTHR43109:SF2	NUCLEOSIDE DIPHOSPHATE KINASE 7
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=12788|UniProtKB=Q9H1J5	Protein Wnt-8a	IDA	8717036	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	XENTR|Xenbase=XB-GENE-491433|UniProtKB=B1H2U0	Pten protein	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000016759|UniProtKB=H2QQP8	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF99	CADHERIN-9
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00010	B cell activation	P00371	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01199	Galpha	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05734	Synaptic vesicle trafficking	P05779	Synaptobrevin	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	HUMAN|HGNC=4579|UniProtKB=P39086	Glutamate receptor ionotropic, kainate 1	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	RCA	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	8687404	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00005	Angiogenesis	P00205	GAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	8270251	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00021	FGF signaling pathway	P00627	ERK1-2	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00057	Wnt signaling pathway	P01444	Wnt	BOVIN|Gene=WNT16|UniProtKB=Q5E9U6	Protein Wnt-16	ISS	11266476	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P04392	P53 pathway feedback loops 1	P04537	p73DeltaN	CHICK|Ensembl=ENSGALG00000007324|UniProtKB=F1N8Z7	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	SCHPO|PomBase=SPCC1919.10c|UniProtKB=O94477	Myosin-52	IC			PTHR13140:SF725	DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	PSEAE|EnsemblGenome=PA0399|UniProtKB=Q9I6A1	Cystathionine beta-synthase	ISS			PTHR10314:SF8	CYSTATHIONINE BETA-SYNTHASE-RELATED
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00059	p53 pathway	P04609	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00060	Ubiquitin proteasome pathway	P01491	E2	PHYPA|Gene=PHYPADRAFT_106208|UniProtKB=A9SCM3	Predicted protein	ISS			PTHR43902:SF2	UBIQUITIN-CONJUGATING ENZYME E2 N
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MACMU|Ensembl=ENSMMUG00000012005|UniProtKB=F7H091	Metabotropic glutamate receptor 2 isoform a	ISS			PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00049	Parkinson disease	P01241	TH	BOVIN|Gene=TH|UniProtKB=P17289	Tyrosine 3-monooxygenase	TAS	12480184	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00006	Apoptosis signaling pathway	P00318	PKCs	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IDA	94179345	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-9966|UniProtKB=Q6TH03	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	RAT|RGD=619965|UniProtKB=P26769	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00029	Huntington disease	P00805	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	TAS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	HUMAN|HGNC=4574|UniProtKB=P48058	Glutamate receptor 4	ISS	12871085	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00019	Endothelin signaling pathway	P00575	furin	MACMU|Ensembl=ENSMMUG00000004657|UniProtKB=G7MVY8	Furin	ISS	11861638	PubMed	PTHR42884:SF1	FURIN
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00030	Hypoxia response via HIF activation	P00817	TOR	MACMU|Ensembl=ENSMMUG00000019325|UniProtKB=F6RVV5	Uncharacterized protein	ISS	14526383	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00009	Axon guidance mediated by netrin	P00363	PI3K	DROME|FlyBase=FBgn0015278|UniProtKB=Q7K3H0	LD28067p	ISS	8662856	PubMed	PTHR10048:SF64	LD28067P
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	CAEEL|WormBase=WBGene00011352|UniProtKB=Q21734	Putative ribosomal protein S6 kinase alpha-1	ISS	6755374	gi	PTHR24351:SF110	RIBOSOMAL PROTEIN S6 KINASE II, ISOFORM A
P00005	Angiogenesis	P00254	GTPase	TAKRU|Ensembl=ENSTRUG00000011944|UniProtKB=H2TZX5	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00047	PDGF signaling pathway	P01143	ERK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04547	Ras	XENTR|Xenbase=XB-GENE-494548|UniProtKB=F7EC26	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00059	p53 pathway	G01579	PTEN	XENTR|Xenbase=XB-GENE-491433|UniProtKB=B1H2U0	Pten protein	ISS	10555148	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00023	General transcription regulation	P00660	RNA Polymerase II	CHICK|Ensembl=ENSGALG00000002591|UniProtKB=F1NHV9	Uncharacterized protein	ISS			PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P00029	Huntington disease	P00810	GAPDH	SCHMA|EnsemblGenome=Smp_056970|UniProtKB=G4V5I2	Glyceraldehyde-3-phosphate dehydrogenase	ISS			PTHR10836:SF52	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED
P00029	Huntington disease	P00790	beta-Tubulin	MOUSE|MGI=MGI=1915201|UniProtKB=Q922F4	Tubulin beta-6 chain	TAS	9454836	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00049	Parkinson disease	P01238	14-3-3	DANRE|ZFIN=ZDB-GENE-061023-2|UniProtKB=E7F354	Uncharacterized protein	ISS	1317796	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P04398	p53 pathway feedback loops 2	P04651	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00034	Integrin signalling pathway	P00927	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00053	T cell activation	P01318	PKC-theta	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00047	PDGF signaling pathway	P01157	MAPKAPK2	MOUSE|MGI=MGI=109298|UniProtKB=P49138	MAP kinase-activated protein kinase 2	ISS	9628873	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P06664	Gonadotropin-releasing hormone receptor pathway	P06834	MAP3Ks	MOUSE|MGI=MGI=1346879|UniProtKB=Q66L42	Mitogen-activated protein kinase kinase kinase 10	RCA	9639556	PubMed	PTHR43997:SF5	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 10
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	LEIMA|EnsemblGenome=LmjF.18.1080|UniProtKB=Q27687	Protein kinase A catalytic subunit	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00021	FGF signaling pathway	P00625	MKK3,6	MOUSE|MGI=MGI=1346868|UniProtKB=O09110	Dual specificity mitogen-activated protein kinase kinase 3	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00018	EGF receptor signaling pathway	P00542	EGFR	ANOGA|Gene=AgaP_AGAP008819|UniProtKB=Q7PPN5	Receptor protein-tyrosine kinase (Fragment)	IGI	21901296	PubMed	PTHR24416:SF95	EPIDERMAL GROWTH FACTOR RECEPTOR
P05912	Dopamine receptor mediated signaling pathway	P05960	VAT2	HUMAN|HGNC=10935|UniProtKB=Q05940	Synaptic vesicular amine transporter	IC	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00056	VEGF signaling pathway	P01408	Akt/PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00189	Fzd	BOVIN|Ensembl=ENSBTAG00000002107|UniProtKB=A7MB15	FZD1 protein	ISS	11212302	PubMed	PTHR11309:SF81	FRIZZLED-1
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01294	NFAT	MACMU|Ensembl=ENSMMUG00000022596|UniProtKB=F6Z7T2	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF5	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 1
P00019	Endothelin signaling pathway	P00566	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00786	ARF	HUMAN|HGNC=652|UniProtKB=P84077	ADP-ribosylation factor 1	IPI	11752622	PubMed	PTHR11711:SF234	ADP-RIBOSYLATION FACTOR 1
P00057	Wnt signaling pathway	P01446	Calcineurin	HUMAN|HGNC=9316|UniProtKB=P48454	Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform	IDA	12091710	PubMed	PTHR11668:SF186	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT GAMMA ISOFORM
P00021	FGF signaling pathway	P00634	MEKK1-5	PANTR|Ensembl=ENSPTRG00000012427|UniProtKB=H2QIN7	Mitogen-activated protein kinase kinase kinase 2	ISS	8649450	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00047	PDGF signaling pathway	P01153	GSK3	CIOIN|Ensembl=ENSCING00000001821|UniProtKB=Q9NL43	Glycogen synthase kinase	ISS	12615961	PubMed	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IDA	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00054	Toll receptor signaling pathway	P01352	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04393	Ras Pathway	P04543	MEKK1/4	MOUSE|MGI=MGI=1346875|UniProtKB=O08648	Mitogen-activated protein kinase kinase kinase 4	IDA	9079650	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00047	PDGF signaling pathway	P01159	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00047	PDGF signaling pathway	P01154	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00034	Integrin signalling pathway	P00907	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00059	p53 pathway	P01485	p53	PANTR|Ensembl=ENSPTRG00000015733|UniProtKB=H2QNY5	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00029	Huntington disease	P00807	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g188243|UniProtKB=A7SCN8	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00005	Angiogenesis	P00181	SHP2	MACMU|Ensembl=ENSMMUG00000013253|UniProtKB=F6ZJD8	Tyrosine-protein phosphatase non-receptor type	ISS	14525967	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IDA	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	CAEBR|Gene=CBG05056|UniProtKB=A8WZ27	Protein CBR-GLT-4	ISS	94365697	PubMed	PTHR11958:SF56	SODIUM-DEPENDENT EXCITATORY AMINO ACID TRANSPORTER GLT-4-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00048	PI3 kinase pathway	P01179	PKB	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	11832947	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008026|UniProtKB=H2QAZ2	Syntaxin 1B	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	MACMU|Ensembl=ENSMMUG00000014498|UniProtKB=F7GEI8	Uncharacterized protein	ISS	14507926	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00030	Hypoxia response via HIF activation	P00814	P300	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00005	Angiogenesis	P00254	GTPase	CHICK|Ensembl=ENSGALG00000001569|UniProtKB=Q9PSX7	Rho-related GTP-binding protein RhoC	ISS	12090470	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00006	Apoptosis signaling pathway	P00310	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02741	Flavin biosynthesis	P02937	3,4-Dihydroxy-2-butanone-4-phosphate synthase	SCHPO|PomBase=SPBC23E6.06c|UniProtKB=O60181	3,4-dihydroxy-2-butanone 4-phosphate synthase	ISS			PTHR21327:SF18	3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00003	Alzheimer disease-amyloid secretase pathway	P00108	ADAM10	XENTR|Xenbase=XB-GENE-945388|UniProtKB=F6QEN9	Uncharacterized protein	ISS	10097139	PubMed	PTHR11905:SF4	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 10
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P02752	Mannose metabolism	P03015	GDP-Mannose 4,6-dehydratase	CAEEL|WormBase=WBGene00010166|UniProtKB=O45583	GDP-mannose 4,6 dehydratase 2	IEA	9851916	PubMed	PTHR43715:SF1	GDP-MANNOSE 4,6 DEHYDRATASE
P00036	Interleukin signaling pathway	P00965	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	IC	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00049	Parkinson disease	P01208	Hsp70	PHYIT|EnsemblGenome=PITG_11244|UniProtKB=D0NGJ2	Heat shock 70 kDa protein	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00019	Endothelin signaling pathway	P00570	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01168	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01435	SWI/SNF	DROME|FlyBase=FBgn0000212|UniProtKB=P25439	ATP-dependent helicase brm	IDA	11532957	PubMed	PTHR10799:SF854	ATP-DEPENDENT HELICASE BRM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	CANLF|Ensembl=ENSCAFG00000024151|UniProtKB=E2R795	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00054	Toll receptor signaling pathway	P01345	IKKalpha	RAT|RGD=1306661|UniProtKB=G3V926	Conserved helix-loop-helix ubiquitous kinase (Predicted)	ISS	9346484	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	IGI	11707292	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00006	Apoptosis signaling pathway	P00296	DAXX	PANTR|Ensembl=ENSPTRG00000018045|UniProtKB=H2QST5	Uncharacterized protein	ISS	10698492	PubMed	PTHR12766:SF7	DEATH DOMAIN-ASSOCIATED PROTEIN 6
P02785	Valine biosynthesis	P03218	Dihydroxy isovalerate dehydratase	THEMA|EnsemblGenome=TM_0551|UniProtKB=Q9WZ21	Dihydroxy-acid dehydratase	ISS			PTHR43661:SF3	DIHYDROXY-ACID DEHYDRATASE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TRIAD|EnsemblGenome=TriadG63375|UniProtKB=B3S5E4	Non-muscle actin 6.2	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02780	Thiamin metabolism	P03184	Thiamine triphosphatase	MACMU|Ensembl=ENSMMUG00000004142|UniProtKB=F6XKY8	Thiamine-triphosphatase	ISS	11827967	PubMed	PTHR14586:SF1	THIAMINE-TRIPHOSPHATASE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	MACMU|Ensembl=ENSMMUG00000003857|UniProtKB=F7HA84	Nucleoside diphosphate kinase	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P00057	Wnt signaling pathway	P01448	CBP	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	IDA	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00019	Endothelin signaling pathway	P00577	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	1171954	gi	PTHR10048:SF14	PI-3 KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01212	p38 MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00059	p53 pathway	P04622	Sin3	BOVIN|Ensembl=ENSBTAG00000009985|UniProtKB=F1MTR3	Uncharacterized protein	ISS	10441327	PubMed	PTHR12346:SF2	PAIRED AMPHIPATHIC HELIX PROTEIN SIN3A
P00057	Wnt signaling pathway	P01465	Ggamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT4G36450|UniProtKB=O23236	Mitogen-activated protein kinase 14	ISS	11707292	PubMed	PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	TAS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02731	Biotin biosynthesis	P02856	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	FUSNN|EnsemblGenome=FN1002|UniProtKB=Q8RET8	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	ISS			PTHR42684:SF3	ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05731	GABA-B receptor II signaling	P05754	Ggamma	HUMAN|HGNC=4403|UniProtKB=P61952	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	RCA	2122451	PubMed	PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	ANOGA|EnsemblGenome=AGAP002578|UniProtKB=F5HKU8	AGAP002578-PB	ISS	14624853	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P00004	Alzheimer disease-presenilin pathway	P00144	Ire-1	PANTR|Ensembl=ENSPTRG00000009535|UniProtKB=H2QDP0	Uncharacterized protein	ISS	10619423	PubMed	PTHR13954:SF17	SERINE/THREONINE-PROTEIN KINASE/ENDORIBONUCLEASE IRE1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=107716|UniProtKB=F8VQB6	Unconventional myosin-X	IC			PTHR13140:SF276	UNCONVENTIONAL MYOSIN-X
P00008	Axon guidance mediated by Slit/Robo	P00344	Netrin	MACMU|Ensembl=ENSMMUG00000000004|UniProtKB=F7GVW8	Uncharacterized protein	ISS			PTHR10574:SF292	NETRIN-3
P04395	Vasopressin synthesis	P04596	Endo Peptidase	ORNAN|Ensembl=ENSOANG00000004177|UniProtKB=F6TXM6	Uncharacterized protein	ISS	9695945	PubMed	PTHR42881:SF2	PROLYL ENDOPEPTIDASE
P00034	Integrin signalling pathway	P00925	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEEL|WormBase=WBGene00018620|UniProtKB=O44588	Uncharacterized protein	ISS	3045562	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IGI	10669416	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00018	EGF receptor signaling pathway	P00565	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MOUSE|MGI=MGI=1339711|UniProtKB=Q5SX40	Myosin-1	ISS	89264452	PubMed	PTHR13140:SF484	MYOSIN-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00034	Integrin signalling pathway	P00920	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00051	TCA cycle	P01267	Citrate Synthase	DICDI|dictyBase=DDB_G0267426|UniProtKB=Q8MQU6	Citrate synthase, peroxisomal	IDA	15225305	PubMed	PTHR11739:SF4	CITRATE SYNTHASE, PEROXISOMAL
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=4599|UniProtKB=Q14831	Metabotropic glutamate receptor 7	IDA	11431030	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	PANTR|Ensembl=ENSPTRG00000006510|UniProtKB=H2Q8K1	Presenilin	ISS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00016	Cytoskeletal regulation by Rho GTPase	P00521	Profilin	DROME|FlyBase=FBgn0000308|UniProtKB=P25843	Profilin	ISS			PTHR11604:SF0	PROFILIN
P00048	PI3 kinase pathway	P01177	P110ACT	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00034	Integrin signalling pathway	P00915	PTP-PEST	MACMU|Ensembl=ENSMMUG00000009004|UniProtKB=F7EGH9	Uncharacterized protein	ISS	8887669	PubMed	PTHR19134:SF283	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 12
P00049	Parkinson disease	P01227	20S proteasome	ORYSJ|EnsemblGenome=OS03G0387100|UniProtKB=Q10KF0	Proteasome subunit alpha type-2	ISS	12859888	PubMed	PTHR11599:SF16	PROTEASOME SUBUNIT ALPHA TYPE-2
P00049	Parkinson disease	P01227	20S proteasome	SCHPO|PomBase=SPAC323.02c|UniProtKB=Q9UT97	Probable proteasome subunit alpha type-5	TAS	12859888	PubMed	PTHR11599:SF14	PROTEASOME SUBUNIT ALPHA TYPE-5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	MOUSE|MGI=MGI=104742|UniProtKB=P63250	G protein-activated inward rectifier potassium channel 1	IDA			PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	STRPU|EnsemblGenome=SPU_006797|UniProtKB=W4XTP5	Uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00018	EGF receptor signaling pathway	P00547	PP2A	RAT|RGD=708460|UniProtKB=Q64620	Serine/threonine-protein phosphatase 6 catalytic subunit	ISS			PTHR11668:SF24	SERINE/THREONINE-PROTEIN PHOSPHATASE 6 CATALYTIC SUBUNIT
P00005	Angiogenesis	P00244	MAPKAPK2/3	MACMU|Ensembl=ENSMMUG00000010495|UniProtKB=F7BFL2	MAP kinase-activated protein kinase 3	ISS	11335727	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00775	Rac	DROME|FlyBase=FBgn0014011|UniProtKB=P48554	Ras-related protein Rac2	TAS			PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00059	p53 pathway	G04694	p110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00057	Wnt signaling pathway	P01451	Galpha	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IDA	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	RAT|RGD=2743|UniProtKB=P31421	Metabotropic glutamate receptor 2	ISS	12488551	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00057	Wnt signaling pathway	P01440	Cadherin	ANOGA|EnsemblGenome=AGAP003579|UniProtKB=Q7QAQ8	AGAP003579-PA	ISS	8120095	PubMed	PTHR43956:SF8	CADHERIN 88C-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00049	Parkinson disease	P01211	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	11204774	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ARATH|TAIR=AT3G18780|UniProtKB=Q96292	Actin-2	ISS	14684598	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01408	Akt/PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	G01540	BDNF	PANTR|Ensembl=ENSPTRG00000028696|UniProtKB=Q5IS78	Brain-derived neurotrophic factor	ISS	12117585	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00017	DNA replication	P00536	DNA Topisomerase	MONDO|Ensembl=ENSMODG00000014954|UniProtKB=F7D0D3	DNA topoisomerase 2	ISS			PTHR10169:SF36	DNA TOPOISOMERASE 2-BETA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8972|UniProtKB=O00750	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	IPI	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CRYNJ|EnsemblGenome=CNA04650|UniProtKB=Q5KP06	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00025	Hedgehog signaling pathway	P00691	CBP	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00049	Parkinson disease	P01208	Hsp70	LEIMA|EnsemblGenome=LmjF.30.2460|UniProtKB=Q4Q747	Putative heat shock 70-related protein 1,mitochondrial	IDA	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P00053	T cell activation	P01300	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	BOVIN|Gene=POLR2F|UniProtKB=Q32PE0	DNA-directed RNA polymerases I, II, and III subunit RPABC2	ISS	415387	gi	PTHR10773:SF12	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2
P00019	Endothelin signaling pathway	P00575	furin	BOVIN|Gene=FURIN|UniProtKB=Q28193	Furin	ISS	11861638	PubMed	PTHR42884:SF1	FURIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00634	MEKK1-5	HUMAN|HGNC=6858|UniProtKB=O95382	Mitogen-activated protein kinase kinase kinase 6	IPI	9875215	PubMed	PTHR11584:SF391	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 6
P00056	VEGF signaling pathway	P01417	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05974	G-Protein (i)	DAPPU|EnsemblGenome=DAPPUDRAFT_59367|UniProtKB=E9H7Z0	Guanine nucleotide-binding protein G(O) subunit alpha 1	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00045	Notch signaling pathway	G01541	E(spl)-C genes	DROME|FlyBase=FBgn0027788|UniProtKB=Q7KM13	Hairy/enhancer-of-split related with YRPW motif protein	IC			PTHR10985:SF97	HAIRY/ENHANCER-OF-SPLIT RELATED WITH YRPW MOTIF PROTEIN
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	PANTR|Ensembl=ENSPTRG00000004718|UniProtKB=H2Q5I0	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	ISS	11360179	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	RAT|RGD=2735|UniProtKB=Q63273	Glutamate receptor ionotropic, kainate 5	ISS	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00018	EGF receptor signaling pathway	P00543	ERK1-2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00029	Huntington disease	P00774	Dynein complex	YEAST|SGD=S000001762|UniProtKB=P36022	Dynein heavy chain, cytoplasmic	IPI	9454836	PubMed	PTHR10676:SF314	CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00019	Endothelin signaling pathway	P00589	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IGI	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01302	CD3 eta	MACMU|Ensembl=ENSMMUG00000017593|UniProtKB=G7NCB9	Uncharacterized protein	ISS	9886373	PubMed	PTHR10570:SF9	T-CELL SURFACE GLYCOPROTEIN CD3 EPSILON CHAIN
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00030	Hypoxia response via HIF activation	P00825	Thioredoxin	BACSU|EnsemblGenome=BSU28500|UniProtKB=P14949	Thioredoxin	ISS			PTHR10438:SF215	THIOREDOXIN DOMAIN-CONTAINING PROTEIN, MITOCHONDRIAL
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00239	Eph	DANRE|ZFIN=ZDB-GENE-010618-2|UniProtKB=Q90Z33	Ephrin B1	ISS			PTHR11304:SF17	EPHRIN-B1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00014	Cholesterol biosynthesis	P00496	Diphosphomevalonate decarboxylase	ANOGA|EnsemblGenome=AGAP001611|UniProtKB=Q7PXV2	AGAP001611-PA	ISS	4505289	gi	PTHR10977:SF3	DIPHOSPHOMEVALONATE DECARBOXYLASE
P00034	Integrin signalling pathway	P00947	Laminin	PANTR|Ensembl=ENSPTRG00000005315|UniProtKB=H2Q6M9	Uncharacterized protein	ISS	2538453	PubMed	PTHR10574:SF282	NETRIN-4
P00040	Metabotropic glutamate receptor group II pathway	G01540	BDNF	HUMAN|HGNC=1033|UniProtKB=P23560	Brain-derived neurotrophic factor	ISS	11724916	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PHYPA|Gene=PHYPADRAFT_107830|UniProtKB=A9TBG2	Actin 7	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	ANOGA|EnsemblGenome=AGAP003000|UniProtKB=Q7PGR0	AGAP003000-PA	ISS			PTHR23507:SF14	GH08173P
P00016	Cytoskeletal regulation by Rho GTPase	P00507	Rho	CAEEL|WormBase=WBGene00004357|UniProtKB=Q22038	Ras-like GTP-binding protein rhoA	ISS	11973360	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	RAT|RGD=3377|UniProtKB=P63088	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	ISS	8392016	PubMed	PTHR11668:SF204	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-GAMMA CATALYTIC SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00877	MLCK	CHICK|Ensembl=ENSGALG00000006273|UniProtKB=E1BX17	Uncharacterized protein	IDA	600922	OMIM	PTHR45210:SF1	MYOSIN LIGHT CHAIN KINASE 2, SKELETAL/CARDIAC MUSCLE
P00029	Huntington disease	P00790	beta-Tubulin	SCHPO|PomBase=SPBC26H8.07c|UniProtKB=P05219	Tubulin beta chain	TAS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00047	PDGF signaling pathway	P01154	Ras	PANTR|Ensembl=ENSPTRG00000004731|UniProtKB=H2Q5J1	RAS-like, estrogen-regulated, growth inhibitor	ISS			PTHR24070:SF373	RAS-RELATED AND ESTROGEN-REGULATED GROWTH INHIBITOR
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000025240|UniProtKB=F7A7I3	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02738	De novo purine biosynthesis	P02909	GDP reductase	HUMAN|HGNC=17296|UniProtKB=Q7LG56	Ribonucleoside-diphosphate reductase subunit M2 B	ISS			PTHR23409:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 B
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	CANLF|Gene=DRD2|UniProtKB=Q9GJU1	D(2) dopamine receptor	ISS	1319557	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	CIOIN|Ensembl=ENSCING00000008616|UniProtKB=F6T2A6	Uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00048	PI3 kinase pathway	P01177	P110ACT	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01199	Galpha	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00036	Interleukin signaling pathway	P00990	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00045	Notch signaling pathway	G01541	E(spl)-C genes	MACMU|Ensembl=ENSMMUG00000018861|UniProtKB=F6XRP0	Uncharacterized protein	ISS	10860664	PubMed	PTHR10985:SF79	HAIRY/ENHANCER-OF-SPLIT RELATED WITH YRPW MOTIF-LIKE PROTEIN
P00010	B cell activation	P00385	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00053	T cell activation	P01319	PAK	BOVIN|Ensembl=ENSBTAG00000010191|UniProtKB=Q08E52	Serine/threonine-protein kinase PAK 1	ISS	14580336	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00059	p53 pathway	P01486	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000001583|UniProtKB=F7BBM1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00012	Cadherin signaling pathway	P00470	F-actin	TAKRU|Ensembl=ENSTRUG00000014318|UniProtKB=H2UI49	Uncharacterized protein	IC	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04580	TRH Receptor	XENTR|Xenbase=XB-GENE-1018399|UniProtKB=F7ERM9	Uncharacterized protein	ISS			PTHR24243:SF51	PROTEIN TRHR2
P04393	Ras Pathway	P04570	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	YEAST|SGD=S000000028|UniProtKB=P31109	Synaptobrevin homolog 1	IC			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00149	Pen-2	XENTR|Xenbase=XB-GENE-854651|UniProtKB=Q28GF7	Presenilin enhancer 2 homolog	ISS	12110170	PubMed	PTHR16318:SF0	GAMMA-SECRETASE SUBUNIT PEN-2
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	XENTR|Xenbase=XB-GENE-478121|UniProtKB=F6VPH2	Uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8713|UniProtKB=Q9Y5F9	Protocadherin gamma-B6	IDA	8120095	PubMed	PTHR24028:SF66	PROTOCADHERIN GAMMA-B6
P00005	Angiogenesis	P00233	CSL	DANRE|ZFIN=ZDB-GENE-031117-1|UniProtKB=A4FTT3	Rbpja protein	ISS	12145413	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	HUMAN|HGNC=403|UniProtKB=P51648	Fatty aldehyde dehydrogenase	IC	14724059	PubMed	PTHR43570:SF9	FATTY ALDEHYDE DEHYDROGENASE
P02730	Asparagine and aspartate biosynthesis	P02853	Asparagine synthetase	YEAST|SGD=S000003356|UniProtKB=P49090	Asparagine synthetase [glutamine-hydrolyzing] 2	ISS			PTHR11772:SF2	ASPARAGINE SYNTHETASE
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P05731	GABA-B receptor II signaling	P05754	Ggamma	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00021	FGF signaling pathway	P00641	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	PANTR|Ensembl=ENSPTRG00000001749|UniProtKB=H2Q0Q4	Uncharacterized protein	ISS	11976940	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00747	Rhodopsin	TAKRU|Ensembl=ENSTRUG00000010617|UniProtKB=Q9IAH7	Rhodopsin	IDA	1634520	PubMed	PTHR24240:SF15	RHODOPSIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00053	T cell activation	P01297	MEKK	PANTR|Ensembl=ENSPTRG00000016891|UniProtKB=H2R5K3	Uncharacterized protein	RCA	12049732	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	USTMA|Gene=UMAG_11232|UniProtKB=A0A0D1DMT3	Chromosome 22, whole genome shotgun sequence	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04393	Ras Pathway	P04547	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00951	Jnk	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00046	Oxidative stress response	P01131	MKP5	ORNAN|Ensembl=ENSOANG00000014855|UniProtKB=F7B750	Dual specificity protein phosphatase	ISS			PTHR10159:SF305	DUAL SPECIFICITY PROTEIN PHOSPHATASE 7
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IC	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00634	MEKK1-5	MACMU|Ensembl=ENSMMUG00000018568|UniProtKB=F6YLW2	Uncharacterized protein	ISS	8621389	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	STRPU|Gene=CYIIIA|UniProtKB=P53474	Actin, cytoskeletal 3A	ISS	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01451	Galpha	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	G06882	RICS	MOUSE|MGI=MGI=2450166|UniProtKB=Q811P8	Rho GTPase-activating protein 32	RCA			PTHR15729:SF9	RHO GTPASE-ACTIVATING PROTEIN 32
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	MONDO|Ensembl=ENSMODG00000001807|UniProtKB=F6Y7R9	Uncharacterized protein	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MACMU|Ensembl=ENSMMUG00000017431|UniProtKB=F7HPP3	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00018	EGF receptor signaling pathway	P00565	PKC	CAEEL|WormBase=WBGene00012019|UniProtKB=O45818	Serine/threonine-protein kinase dkf-2	ISS			PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P00053	T cell activation	P01332	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00053	T cell activation	P01333	cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01192	p110	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05939	GRK6	BOVIN|Ensembl=ENSBTAG00000043994|UniProtKB=E1BP29	Protein-serine/threonine kinase	ISS	12032308	PubMed	PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MONDO|Ensembl=ENSMODG00000018065|UniProtKB=F7G485	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00814	P300	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00057	Wnt signaling pathway	P01435	SWI/SNF	YEAST|SGD=S000000449|UniProtKB=P38144	ISWI chromatin-remodeling complex ATPase ISW1	IDA	11532957	PubMed	PTHR10799:SF856	ISWI CHROMATIN-REMODELING COMPLEX ATPASE ISW1
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	ISS	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CHICK|Ensembl=ENSGALG00000007712|UniProtKB=F1NTJ5	Uncharacterized protein	ISS			PTHR13140:SF277	UNCONVENTIONAL MYOSIN-IB
P00018	EGF receptor signaling pathway	P00564	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	4757952	gi	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00057	Wnt signaling pathway	P01457	GBeta	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	PANTR|Ensembl=ENSPTRG00000009762|UniProtKB=H2QE24	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04452	proopiomelanocortin	BOVIN|Ensembl=ENSBTAG00000007897|UniProtKB=P01190	Pro-opiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00005	Angiogenesis	P00243	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00211	GSK3beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00057	Wnt signaling pathway	P01435	SWI/SNF	MACMU|Ensembl=ENSMMUG00000004005|UniProtKB=F6XQL7	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1	ISS	11532957	PubMed	PTHR13711:SF206	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY E MEMBER 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00030	Hypoxia response via HIF activation	P00819	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00226	Delta/Serrate	HUMAN|HGNC=2909|UniProtKB=Q9NYJ7	Delta-like protein 3	ISS	10742114	PubMed	PTHR24044:SF308	DELTA-LIKE PROTEIN 3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00059	p53 pathway	P04609	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	IC	10704417	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CANLF|Ensembl=ENSCAFG00000016020|UniProtKB=O18840	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02736	Coenzyme A biosynthesis	P02882	Pantothenate cysteine ligase	HUMAN|HGNC=25686|UniProtKB=Q9HAB8	Phosphopantothenate--cysteine ligase	ISS			PTHR12290:SF2	PHOSPHOPANTOTHENATE--CYSTEINE LIGASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	RAT|RGD=70989|UniProtKB=Q78EA7	Bone morphogenetic protein receptor type-1A	TAS	9395284	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P02747	Histidine biosynthesis	P02991	Histidinephosphate aminotransferase	MYCTU|EnsemblGenome=Rv1600|UniProtKB=P9WML7	Histidinol-phosphate aminotransferase	ISS			PTHR42885:SF2	HISTIDINOL-PHOSPHATE AMINOTRANSFERASE
P00057	Wnt signaling pathway	P01465	Ggamma	PANTR|Ensembl=ENSPTRG00000000843|UniProtKB=H2QZN8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00018	EGF receptor signaling pathway	P00557	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00586	Gq	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	TAS	9298898	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01409	cPLA2	BOVIN|Ensembl=ENSBTAG00000013298|UniProtKB=A4IFJ5	Cytosolic phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00846	JAK	PANTR|Ensembl=ENSPTRG00000020744|UniProtKB=H2QWZ4	Tyrosine-protein kinase	ISS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	CANLF|Ensembl=ENSCAFG00000009203|UniProtKB=F1PVZ1	Muscarinic acetylcholine receptor	ISS	11166329	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P02751	Lysine biosynthesis	P03007	Diaminopimelate decarboxylase	DEIRA|EnsemblGenome=DR_1758|UniProtKB=Q9RTK2	Diaminopimelate decarboxylase	ISS			PTHR43727:SF2	DIAMINOPIMELATE DECARBOXYLASE 1, CHLOROPLASTIC-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01157	MAPKAPK2	HUMAN|HGNC=6887|UniProtKB=P49137	MAP kinase-activated protein kinase 2	ISS	10779545	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00021	FGF signaling pathway	P00644	p38	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	8920915	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00021	FGF signaling pathway	P00644	p38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IGI	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00052	TGF-beta signaling pathway	P01289	I-Smads	MOUSE|MGI=MGI=1336883|UniProtKB=O35182	Mothers against decapentaplegic homolog 6	IGI	9335505	PubMed	PTHR13703:SF28	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 6
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	RAT|RGD=3567|UniProtKB=P49799	Regulator of G-protein signaling 4	ISS	8756726	PubMed	PTHR10845:SF184	REGULATOR OF G-PROTEIN SIGNALING 4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00737	Rap1GAP	MACMU|Ensembl=ENSMMUG00000012163|UniProtKB=F7GW56	Uncharacterized protein	ISS	10419452	PubMed	PTHR15711:SF31	GTPASE-ACTIVATING RAP/RAN-GAP DOMAIN-LIKE PROTEIN 3
P00021	FGF signaling pathway	P00645	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00056	VEGF signaling pathway	P01423	p38MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	MOUSE|MGI=MGI=94924|UniProtKB=P61168	D(2) dopamine receptor	RCA	2137198	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00021	FGF signaling pathway	P00644	p38	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	IGI	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	18021322	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00021	FGF signaling pathway	P00648	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IGI	94179345	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	RCA	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00053	T cell activation	P01312	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00030	Hypoxia response via HIF activation	P00824	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	TAS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00101	BACE-1	HUMAN|HGNC=933|UniProtKB=P56817	Beta-secretase 1	IDA	10531052	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	88241036	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	HUMAN|HGNC=1403|UniProtKB=P54284	Voltage-dependent L-type calcium channel subunit beta-3	IC			PTHR11824:SF8	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IDA	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00029	Huntington disease	P00780	Microtubule	MONDO|Ensembl=ENSMODG00000017213|UniProtKB=F6WYK8	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00015	Circadian clock system	P00502	Casein kinase I	BOVIN|Ensembl=ENSBTAG00000019986|UniProtKB=P35508	Casein kinase I isoform delta	ISS	10617630	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P04398	p53 pathway feedback loops 2	G04709	MDM-2	MACMU|Ensembl=ENSMMUG00000011236|UniProtKB=F6WXF0	Uncharacterized protein	ISS			PTHR13844:SF20	PROTEIN MDM4
P00021	FGF signaling pathway	P00641	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00007	Axon guidance mediated by semaphorins	P00340	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000009626|UniProtKB=F6ZYQ0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00054	Toll receptor signaling pathway	P01356	ERK2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00012	Cadherin signaling pathway	P00470	F-actin	CHICK|Gene=ACTR2|UniProtKB=P53488	Actin-related protein 2	ISS	10974003	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00057	Wnt signaling pathway	P01443	Phospholipase C	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	IDA	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00025	Hedgehog signaling pathway	P00692	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04398	p53 pathway feedback loops 2	P04665	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	RAT|RGD=2733|UniProtKB=P42260	Glutamate receptor ionotropic, kainate 2	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00050	Plasminogen activating cascade	P01257	tPA	MOUSE|MGI=MGI=97610|UniProtKB=P11214	Tissue-type plasminogen activator	ISS	137121	gi	PTHR44617:SF1	TISSUE-TYPE PLASMINOGEN ACTIVATOR
P00018	EGF receptor signaling pathway	P00547	PP2A	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00274	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00004	Alzheimer disease-presenilin pathway	P00153	gammacatenin	BOVIN|Ensembl=ENSBTAG00000017685|UniProtKB=Q8SPJ1	Junction plakoglobin	ISS	9172160	PubMed	PTHR23315:SF12	JUNCTION PLAKOGLOBIN
P05913	Enkephalin release	P05972	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05913	Enkephalin release	P05973	GPCR (i)	MOUSE|MGI=MGI=97438|UniProtKB=P32300	Delta-type opioid receptor	ISS	11259487	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00036	Interleukin signaling pathway	P00983	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	3449797	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04395	Vasopressin synthesis	P04597	Signal Peptide	HUMAN|HGNC=8528|UniProtKB=P01178	Oxytocin-neurophysin 1	ISS	192340	OMIM	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P06213	DPP signaling pathway	P06289	PPM1A	DROME|FlyBase=FBgn0086361|UniProtKB=Q961C5	Alphabet, isoform E	IEA	http://flybase.org/reports/FBgn0086361.html	Website	PTHR13832:SF524	PROTEIN PHOSPHATASE 1A, MAGNESIUM DEPENDENT, ALPHA ISOFORM-RELATED
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MACMU|Ensembl=ENSMMUG00000016376|UniProtKB=F7G2W1	Uncharacterized protein	ISS	8974401	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CAEEL|WormBase=WBGene00006454|UniProtKB=G5EEN8	AEX-4	IC			PTHR19305:SF10	AEX-4
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00059	p53 pathway	P04615	MTA2	PANTR|Ensembl=ENSPTRG00000003771|UniProtKB=H2Q3V9	Metastasis associated 1 family, member 2	ISS	11099047	PubMed	PTHR10865:SF4	METASTASIS-ASSOCIATED PROTEIN MTA2
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	SYNY3|EnsemblGenome=BAA17318|UniProtKB=P73290	Adenylosuccinate synthetase	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00010	B cell activation	P00373	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IGI	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000021442|UniProtKB=F7EAQ8	Muscarinic acetylcholine receptor	ISS			PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00045	Notch signaling pathway	P01101	Su(H)	MACMU|Ensembl=ENSMMUG00000015828|UniProtKB=F7CE90	Recombining binding protein suppressor of hairless isoform 4	ISS	15187023	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00018	EGF receptor signaling pathway	P00541	Spry	CANLF|Ensembl=ENSCAFG00000006250|UniProtKB=F1Q4C2	Uncharacterized protein	ISS	22024232	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P00034	Integrin signalling pathway	P00928	alpha actinin	RAT|RGD=621792|UniProtKB=Q8R4I6	Actinin alpha 3, isoform CRA_a	IPI	2116421	PubMed	PTHR43947:SF6	ALPHA-ACTININ-3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	9199552	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02913	Thymidylate synthase	BACSU|EnsemblGenome=BSU17680|UniProtKB=P0CI79	Thymidylate synthase 1	ISS			PTHR11548:SF1	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IDA	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	HUMAN|HGNC=4582|UniProtKB=Q16099	Glutamate receptor ionotropic, kainate 4	ISS	11319238	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	DANRE|ZFIN=ZDB-GENE-040718-414|UniProtKB=D7RVR6	Excitatory amino acid transporter SLC1A1	ISS	96032356	PubMed	PTHR11958:SF69	EXCITATORY AMINO ACID TRANSPORTER 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MONDO|Ensembl=ENSMODG00000008382|UniProtKB=F7CDR6	Uncharacterized protein (Fragment)	ISS	11259487	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00059	p53 pathway	P04633	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01300	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	11256888	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	DANRE|ZFIN=ZDB-GENE-020604-1|UniProtKB=Q6IQX1	Myosin, heavy polypeptide 2, fast muscle specific	IC	10938134	PubMed	PTHR13140:SF676	MYOSIN, HEAVY POLYPEPTIDE 2, FAST MUSCLE SPECIFIC
P00048	PI3 kinase pathway	P01190	PDK1 ACT	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	IGI	12855688	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00014	Cholesterol biosynthesis	P00500	Phosphomevalonate kinase	PANTR|Ensembl=ENSPTRG00000001393|UniProtKB=H2Q057	Phosphomevalonate kinase	ISS			PTHR13101:SF1	PHOSPHOMEVALONATE KINASE
P04393	Ras Pathway	P04570	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00587	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01306	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P05730	Endogenous cannabinoid signaling	P05746	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00018	EGF receptor signaling pathway	P00562	p38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00003	Alzheimer disease-amyloid secretase pathway	P00107	kinesin	MACMU|Ensembl=ENSMMUG00000011668|UniProtKB=F7HGT8	Uncharacterized protein	ISS	11740561	PubMed	PTHR19959:SF139	KINESIN LIGHT CHAIN 4
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04398	p53 pathway feedback loops 2	P04650	WIP-1	MACMU|Ensembl=ENSMMUG00000018049|UniProtKB=F7HUA9	Uncharacterized protein	ISS			PTHR13832:SF359	PROTEIN PHOSPHATASE 1D
P05731	GABA-B receptor II signaling	P05754	Ggamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00005	Angiogenesis	P00234	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	7689150	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00036	Interleukin signaling pathway	P00996	STAT	HUMAN|HGNC=11362|UniProtKB=P42224	Signal transducer and activator of transcription 1-alpha/beta	IC	15825084	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00015	Circadian clock system	P00504	Per	HUMAN|HGNC=8847|UniProtKB=P56645	Period circadian protein homolog 3	IDA	15700718	PubMed	PTHR11269:SF13	PERIOD CIRCADIAN PROTEIN HOMOLOG 3
P00005	Angiogenesis	P00223	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P06664	Gonadotropin-releasing hormone receptor pathway	P06798	PKCe/theta	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	RCA	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00049	Parkinson disease	P01236	Casein kinase II	PANTR|Ensembl=ENSPTRG00000013147|UniProtKB=H2QJS7	Uncharacterized protein	ISS	10806215	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00024	Glycolysis	P00673	Triosephosphate isomerase	YEAST|SGD=S000002457|UniProtKB=P00942	Triosephosphate isomerase	RCA			PTHR21139:SF15	TRIOSEPHOSPHATE ISOMERASE
P00034	Integrin signalling pathway	P00925	MEK	HUMAN|HGNC=6843|UniProtKB=P46734	Dual specificity mitogen-activated protein kinase kinase 3	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00047	PDGF signaling pathway	P01162	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04393	Ras Pathway	P04558	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DANRE|ZFIN=ZDB-GENE-030131-8225|UniProtKB=Q7SZZ5	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000035697|UniProtKB=Q28024	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	G06894	c-fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	RCA	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	ANOGA|EnsemblGenome=AGAP001478|UniProtKB=Q7PXM3	AGAP001478-PA	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	ORYSJ|EnsemblGenome=OS07G0492000|UniProtKB=Q07661	Nucleoside diphosphate kinase 1	ISS			PTHR11349:SF66	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01063	CAT	CANLF|Ensembl=ENSCAFG00000006672|UniProtKB=F1PR75	Uncharacterized protein	ISS	92155737	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P02785	Valine biosynthesis	P03217	Dihydroxy isovalerate reductoisomerase	SCHPO|PomBase=SPBC56F2.12|UniProtKB=P78827	Probable ketol-acid reductoisomerase, mitochondrial	ISS			PTHR21371:SF13	KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL
P00034	Integrin signalling pathway	P00949	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	10982827	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00015	Circadian clock system	G01499	per	HUMAN|HGNC=8846|UniProtKB=O15055	Period circadian protein homolog 2	IDA	11232563	PubMed	PTHR11269:SF9	PERIOD CIRCADIAN PROTEIN HOMOLOG 2
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P05918	p38 MAPK pathway	P05921	MKP5	MONDO|Ensembl=ENSMODG00000004672|UniProtKB=F6U725	Uncharacterized protein	ISS	10597297	PubMed	PTHR10159:SF299	DUAL SPECIFICITY PROTEIN PHOSPHATASE 10
P05731	GABA-B receptor II signaling	P05760	AC	MACMU|Ensembl=ENSMMUG00000006421|UniProtKB=F6U2K7	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02748	Isoleucine biosynthesis	P02994	Branched chain amino acid aminotransferase	ARATH|TAIR=AT1G50090|UniProtKB=Q9LPM8	Putative branched-chain-amino-acid aminotransferase 7	ISS			PTHR42825:SF4	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 6-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05938	RhoA	MONDO|Ensembl=ENSMODG00000012981|UniProtKB=F7CS91	Uncharacterized protein	ISS	10556059	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P02751	Lysine biosynthesis	P03009	Aspartokinase	ARATH|TAIR=AT5G14060|UniProtKB=O23653	Aspartokinase 2, chloroplastic	ISS			PTHR21499:SF47	ASPARTOKINASE 2, CHLOROPLASTIC-RELATED
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	BOVIN|Ensembl=ENSBTAG00000033153|UniProtKB=F1MG21	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05915	Opioid proenkephalin pathway	P05993	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00019	Endothelin signaling pathway	P00570	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	RAT|RGD=62030|UniProtKB=P02564	Myosin-7	ISS	10938134	PubMed	PTHR13140:SF344	MYOSIN-7
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	TRIAD|EnsemblGenome=TriadG49626|UniProtKB=B3RKR4	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00011	Blood coagulation	P00429	PN2	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	ISS	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	DANRE|ZFIN=ZDB-GENE-030616-53|UniProtKB=Q71E60	AMPA receptor subunit GluR3B	ISS	12941441	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	IC	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	HALSA|EnsemblGenome=VNG_6351G|UniProtKB=Q9HHK5	Transcription initiation factor IIB 3	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P00057	Wnt signaling pathway	P01451	Galpha	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00310	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MONDO|Ensembl=ENSMODG00000004799|UniProtKB=F6VM87	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00054	Toll receptor signaling pathway	P01352	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	PANTR|Ensembl=ENSPTRG00000020589|UniProtKB=H2QWQ6	Uncharacterized protein	ISS	8163524	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_115565|UniProtKB=C3XYD3	Putative uncharacterized protein	ISS			PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00047	PDGF signaling pathway	P01163	c-Jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00019	Endothelin signaling pathway	P00590	IP3 R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IGI	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00010	B cell activation	P00384	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00020	FAS signaling pathway	P00610	MKK4	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MACMU|Ensembl=ENSMMUG00000010266|UniProtKB=F6PV18	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00047	PDGF signaling pathway	P01159	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05731	GABA-B receptor II signaling	P05752	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	CHICK|Ensembl=ENSGALG00000015835|UniProtKB=F1NZT2	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04375	5HT3 type receptor mediated signaling pathway	P04425	K+ channel	MOUSE|MGI=MGI=1100509|UniProtKB=O35111	Potassium channel subfamily K member 3	ISS	15282272	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00006	Apoptosis signaling pathway	P00313	IKK	MACMU|Ensembl=ENSMMUG00000018476|UniProtKB=F6X938	Uncharacterized protein	ISS	9346484	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P02776	Serine glycine biosynthesis	P03160	Phosphoglycerate dehydrogenase	AQUAE|EnsemblGenome=aq_1905|UniProtKB=O67741	D-3-phosphoglycerate dehydrogenase	ISS			PTHR42938:SF9	FORMATE DEHYDROGENASE 1-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=23212|UniProtKB=Q7Z406	Myosin-14	IC	89264452	PubMed	PTHR13140:SF462	MYOSIN-14
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000001713|UniProtKB=F7FZG1	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF84	CADHERIN-20
P00012	Cadherin signaling pathway	P00470	F-actin	CAEBR|Gene=CBG02162|UniProtKB=A8WS33	Protein CBG02162	ISS	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	CANLF|Ensembl=ENSCAFG00000008027|UniProtKB=E2R0W8	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF44	GROWTH/DIFFERENTIATION FACTOR 5
P00038	JAK/STAT signaling pathway	P01027	STAT	CANLF|Ensembl=ENSCAFG00000000163|UniProtKB=F1PAY3	Signal transducer and activator of transcription	ISS	8085155	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P04398	p53 pathway feedback loops 2	G04708	WIP-1	HUMAN|HGNC=9277|UniProtKB=O15297	Protein phosphatase 1D	ISS			PTHR13832:SF359	PROTEIN PHOSPHATASE 1D
P00009	Axon guidance mediated by netrin	P00366	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	DICPU|Gene=DICPUDRAFT_93216|UniProtKB=F1A421	Guanine nucleotide-binding protein subunit beta	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_114976|UniProtKB=C3YP58	Putative uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	ISS	1504106	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	YEAST|SGD=S000001295|UniProtKB=P07278	cAMP-dependent protein kinase regulatory subunit	ISS	2372396	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	RAT|RGD=2739|UniProtKB=Q00961	Glutamate receptor ionotropic, NMDA 2C	IC	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P05916	Opioid prodynorphin pathway	P06002	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00029	Huntington disease	P00779	TBP	SULSO|EnsemblGenome=SSO0951|UniProtKB=P58178	TATA-box-binding protein	IPI	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P02754	Methylcitrate cycle	P03028	Aconitase	CAEEL|WormBase=WBGene00000040|UniProtKB=Q23500	Probable cytoplasmic aconitate hydratase	ISS			PTHR11670:SF1	ACONITATE HYDRATASE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00047	PDGF signaling pathway	P01168	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01445	Cerebus	CHICK|Ensembl=ENSGALG00000005434|UniProtKB=Q9PWB0	Cerberus	ISS	10067895	PubMed	PTHR15273:SF4	CERBERUS
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	DEIRA|EnsemblGenome=DR_0623|UniProtKB=Q9RWP3	Aspartate aminotransferase	ISS			PTHR11751:SF306	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00203	Erk	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000004896|UniProtKB=F7C2C6	Uncharacterized protein (Fragment)	ISS	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00059	p53 pathway	P01486	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00807	Actin	SCHMA|EnsemblGenome=Smp_161920|UniProtKB=G4VSW5	Putative actin	IDA	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P05913	Enkephalin release	P05974	G-Protein (i)	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	1482697	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00044	Nicotinic acetylcholine receptor signaling pathway	P01095	beta	MONDO|Ensembl=ENSMODG00000017165|UniProtKB=F6QDH4	Uncharacterized protein	ISS	15155845	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P06664	Gonadotropin-releasing hormone receptor pathway	P06759	IRS	MOUSE|MGI=MGI=109334|UniProtKB=P81122	Insulin receptor substrate 2	RCA			PTHR10614:SF7	INSULIN RECEPTOR SUBSTRATE 2
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	CANLF|Gene=PPP1CA|UniProtKB=Q8WMS6	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit	ISS	8392016	PubMed	PTHR11668:SF377	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-ALPHA CATALYTIC SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00004	Alzheimer disease-presenilin pathway	P00118	E-cadherin	PANTR|Ensembl=ENSPTRG00000008270|UniProtKB=H2QBE5	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF319	CADHERIN-1
P02783	Tryptophan biosynthesis	P03206	Anthranilate synthase	BACTN|EnsemblGenome=BT_0531|UniProtKB=Q8AAD4	Anthranilate synthase component II	RCA			PTHR43418:SF4	MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	TAS	9332390	PubMed	PTHR10202:SF13	PRESENILIN-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00045	Notch signaling pathway	P01120	NIcs	HUMAN|HGNC=7881|UniProtKB=P46531	Neurogenic locus notch homolog protein 1	IGI	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00018	EGF receptor signaling pathway	P00552	Ras	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g247341|UniProtKB=A7STP5	Predicted protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	YEAST|SGD=S000005738|UniProtKB=P18851	Guanine nucleotide-binding protein subunit beta	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00006	Apoptosis signaling pathway	P00260	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01311	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	STRPU|Gene=CYIIIB|UniProtKB=P18499	Actin, cytoskeletal 3B	IC	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00931	Integrin beta	PANTR|Ensembl=ENSPTRG00000005006|UniProtKB=H2Q615	Integrin beta	ISS	3487386	PubMed	PTHR10082:SF36	INTEGRIN BETA-7
P00034	Integrin signalling pathway	P00924	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000009626|UniProtKB=F6ZYQ0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	XENTR|Xenbase=XB-GENE-484248|UniProtKB=F7BH92	Serine/threonine-protein kinase receptor (Fragment)	ISS	9395284	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P00029	Huntington disease	P00775	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	10802295	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000011757|UniProtKB=Q9XT97	Presenilin-1	IDA	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00059	p53 pathway	G04694	p110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01447	Dishevelled	MACMU|Ensembl=ENSMMUG00000010542|UniProtKB=F7D0L2	Segment polarity protein dishevelled homolog DVL-2	ISS	11212302	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00005	Angiogenesis	P00210	eNOS	RAT|RGD=3186|UniProtKB=Q62600	Nitric oxide synthase, endothelial	ISS	93055452	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PANTR|Ensembl=ENSPTRG00000002086|UniProtKB=H2Q1A9	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01160	IP3 receptor	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00047	PDGF signaling pathway	P01171	PLCgamma	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00017	DNA replication	P00530	Top	TRYB2|Gene=Tb09.160.4090|UniProtKB=Q38EZ6	DNA topoisomerase 2	ISS	90205953	PubMed	PTHR10169:SF50	SUBFAMILY NOT NAMED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00005	Angiogenesis	P00236	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01026	KA	HUMAN|HGNC=4579|UniProtKB=P39086	Glutamate receptor ionotropic, kainate 1	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00018	EGF receptor signaling pathway	P00542	EGFR	RAT|RGD=69323|UniProtKB=Q62799	Receptor tyrosine-protein kinase erbB-3	IGI	17432904	gi	PTHR24416:SF88	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3
P02762	Pentose phosphate pathway	P03079	Hexokinase	DROME|FlyBase=FBgn0001186|UniProtKB=Q9W330	Phosphotransferase	RCA			PTHR19443:SF53	HEXOKINASE TYPE 1-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00021	FGF signaling pathway	P00647	SHP2	MACMU|Ensembl=ENSMMUG00000010203|UniProtKB=F6SIN0	Tyrosine-protein phosphatase non-receptor type	ISS	14525967	PubMed	PTHR19134:SF65	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 6
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CAEEL|WormBase=WBGene00002975|UniProtKB=Q93329	Uncharacterized protein	IC			PTHR18945:SF492	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	PANTR|Gene=HTR1A|UniProtKB=Q9N298	5-hydroxytryptamine receptor 1A	IDA			PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	RCA	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00049	Parkinson disease	P01234	GRK	MACMU|Ensembl=ENSMMUG00000023790|UniProtKB=F7HT93	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CANLF|Ensembl=ENSCAFG00000000332|UniProtKB=F1P8E3	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00019	Endothelin signaling pathway	P00567	PKG	CANLF|Ensembl=ENSCAFG00000008898|UniProtKB=F6Y448	cGMP-dependent protein kinase	ISS	12764134	PubMed	PTHR24353:SF24	SUBFAMILY NOT NAMED
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	HUMAN|HGNC=9299|UniProtKB=P67775	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00566	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P02778	Sulfate assimilation	P03167	Sulfate adenylyltransferase	MOUSE|MGI=MGI=1330587|UniProtKB=Q60967	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1	ISS			PTHR11055:SF17	BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	10799299	PubMed	PTHR10048:SF14	PI-3 KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MOUSE|MGI=MGI=1309999|UniProtKB=Q922R0	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00048	PI3 kinase pathway	P01188	Gbetagamma	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00023	General transcription regulation	P00668	TFIIB	SULSO|EnsemblGenome=SSO0446|UniProtKB=P58111	Transcription initiation factor IIB 1	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PRIPA|Gene=PPA19914|UniProtKB=H3FCG4	Uncharacterized protein	ISS			PTHR11937:SF359	SUBFAMILY NOT NAMED
P02753	Methionine biosynthesis	P03026	O-Succinyl homoserine lyase	STRCO|EnsemblGenome=CAB46958|UniProtKB=Q59829	Putative cystathionine gamma-lyase	ISS			PTHR11808:SF15	CYSTATHIONINE GAMMA-LYASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00006	Apoptosis signaling pathway	P00274	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05730	Endogenous cannabinoid signaling	P05746	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00057	Wnt signaling pathway	P01446	Calcineurin	DICPU|Gene=DICPUDRAFT_99718|UniProtKB=F1A1T3	Protein phosphatase 2B	ISS	12015605	PubMed	PTHR23056:SF4	PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	CHICK|Ensembl=ENSGALG00000002859|UniProtKB=F6UBD2	Uncharacterized protein	ISS	9252344	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	ARATH|TAIR=AT3G47290|UniProtKB=Q9STZ3	Phosphoinositide phospholipase C 8	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	PANTR|Ensembl=ENSPTRG00000011042|UniProtKB=H2QGF5	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04496	Mdm2	PANTR|Ensembl=ENSPTRG00000005203|UniProtKB=H2R792	Mdm2 p53 binding protein homolog	ISS	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00059	p53 pathway	P01486	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	TAS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	DANRE|ZFIN=ZDB-GENE-020125-4|UniProtKB=F1QKT1	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00034	Integrin signalling pathway	P00922	Collagen	CANLF|Ensembl=ENSCAFG00000014837|UniProtKB=F1PG08	Uncharacterized protein	ISS	10778855	PubMed	PTHR24023:SF539	COLLAGEN ALPHA-2 V  CHAIN
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	MONDO|Ensembl=ENSMODG00000023822|UniProtKB=F6Y6I2	Uncharacterized protein	ISS			PTHR11482:SF42	ORNITHINE DECARBOXYLASE
P00038	JAK/STAT signaling pathway	P01027	STAT	RAT|RGD=1309063|UniProtKB=Q1KQ07	Signal transducer and activator of transcription	ISS	12039028	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	CANLF|Ensembl=ENSCAFG00000018170|UniProtKB=E2RPM8	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	MACMU|Ensembl=ENSMMUG00000021843|UniProtKB=F6RNI3	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00010	B cell activation	P00384	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IDA	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P06664	Gonadotropin-releasing hormone receptor pathway	P06786	ERK1/2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	RCA	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00628	JNK1-3	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01152	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00274	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00047	PDGF signaling pathway	P01173	STAT	TAKRU|Ensembl=ENSTRUG00000015454|UniProtKB=H2URF8	Signal transducer and activator of transcription	ISS			PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00047	PDGF signaling pathway	P01168	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CAEBR|Gene=CBG01949|UniProtKB=A8WRN3	Protein CBR-MGL-1 (Fragment)	ISS			PTHR24060:SF137	METABOTROPIC GLUTAMATE RECEPTOR
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	HUMAN|HGNC=414|UniProtKB=P04075	Fructose-bisphosphate aldolase A	ISS	3391172	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P02752	Mannose metabolism	P03018	Mannose 1-P guanylyl transferase	ARATH|TAIR=AT2G39770|UniProtKB=O22287	Mannose-1-phosphate guanylyltransferase 1	TAS	15225553	gi	PTHR22572:SF136	MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE 1-RELATED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	IDA	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00007	Axon guidance mediated by semaphorins	P00340	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00036	Interleukin signaling pathway	P00979	MAPKAPK2	CHICK|Ensembl=ENSGALG00000000883|UniProtKB=F1NCY7	Uncharacterized protein	ISS			PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000013037|UniProtKB=F7HA59	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF46	PROTOCADHERIN-8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PUCGT|EnsemblGenome=PGTG_05488|UniProtKB=E3K4I1	Actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	PANTR|Ensembl=ENSPTRG00000005438|UniProtKB=H2RBJ1	Actin-related protein 2/3 complex subunit 3	ISS	12473693	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00168	E-cadherin intracellular fragment	HUMAN|HGNC=1748|UniProtKB=P12830	Cadherin-1	IDA	11953314	PubMed	PTHR24027:SF319	CADHERIN-1
P00005	Angiogenesis	P00223	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	ARATH|TAIR=AT3G12980|UniProtKB=Q9LE42	Histone acetyltransferase HAC5	TAS	10769018	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00046	Oxidative stress response	P01135	p38	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=619858|UniProtKB=P70579	Metabotropic glutamate receptor 8	IDA	12351712	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	MACMU|Ensembl=ENSMMUG00000019999|UniProtKB=F7FNE2	Uncharacterized protein	ISS	92370677	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00907	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00773	Duo	MOUSE|MGI=MGI=2685385|UniProtKB=A2CG49	Kalirin	ISS	9285789	PubMed	PTHR22826:SF49	KALIRIN
P00010	B cell activation	P00383	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IDA	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05938	RhoA	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	RCA	12039949	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	XENTR|Xenbase=XB-GENE-494548|UniProtKB=F7EC26	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00029	Huntington disease	P00810	GAPDH	ARATH|TAIR=AT1G16300|UniProtKB=Q5E924	Glyceraldehyde-3-phosphate dehydrogenase GAPCP2, chloroplastic	IPI			PTHR10836:SF52	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED
P00057	Wnt signaling pathway	P01446	Calcineurin	ARATH|TAIR=AT4G33000|UniProtKB=Q7FRS8	Calcineurin B-like protein 10	ISS	12015605	PubMed	PTHR23056:SF26	CALCINEURIN B-LIKE PROTEIN 10
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PANTR|Ensembl=ENSPTRG00000013680|UniProtKB=H2QKN9	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF112	TUBULIN BETA-1 CHAIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	ISS	12488551	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00059	p53 pathway	G04694	p110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	TAS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00398	IP3R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02783	Tryptophan biosynthesis	P03211	Phosphribosyl anthranilate isomerase	BACTN|EnsemblGenome=BT_0528|UniProtKB=Q8AAD7	N-(5'-phosphoribosyl)anthranilate isomerase	ISS			PTHR42894:SF1	N- 5'-PHOSPHORIBOSYL ANTHRANILATE ISOMERASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	RCA	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00045	Notch signaling pathway	P01103	Next	CHICK|Ensembl=ENSGALG00000009020|UniProtKB=E1BTW5	Delta-like protein	IEP	8631496	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00019	Endothelin signaling pathway	P00577	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00805	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=2135882|UniProtKB=Q9EQQ4	Probable G-protein coupled receptor 45	IDA			PTHR24245:SF4	G-PROTEIN COUPLED RECEPTOR 45-RELATED
P00019	Endothelin signaling pathway	P00566	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	G01563	MDM-2	MOUSE|MGI=MGI=107934|UniProtKB=O35618	Protein Mdm4	ISS			PTHR13844:SF20	PROTEIN MDM4
P00046	Oxidative stress response	P01132	c-jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	PANTR|Ensembl=ENSPTRG00000003383|UniProtKB=H2Q376	Uncharacterized protein	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00046	Oxidative stress response	P01121	MKK3/6	RAT|RGD=1306620|UniProtKB=B1H230	Map2k3 protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00029	Huntington disease	P00787	MAPKK4	MOUSE|MGI=MGI=1346869|UniProtKB=P47809	Dual specificity mitogen-activated protein kinase kinase 4	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CAEBR|Gene=CBG02161|UniProtKB=A8WS32	Protein CBG02161	ISS	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	PANTR|Ensembl=ENSPTRG00000008771|UniProtKB=H2QCA0	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF484	MYOSIN-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P06587	Nicotine pharmacodynamics pathway	P06602	PPP1CA	BRAFL|Gene=BRAFLDRAFT_219190|UniProtKB=C3Z434	Serine/threonine-protein phosphatase (Fragment)	ISS	10433257	PubMed	PTHR11668:SF402	SERINE/THREONINE-PROTEIN PHOSPHATASE
P00054	Toll receptor signaling pathway	P01368	MKK2	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	CANLF|Ensembl=ENSCAFG00000016077|UniProtKB=E2QW66	Receptor protein serine/threonine kinase	ISS			PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P06664	Gonadotropin-releasing hormone receptor pathway	P06798	PKCe/theta	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00054	Toll receptor signaling pathway	P01355	AP1	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00015	Circadian clock system	G01497	cry	ORNAN|Ensembl=ENSOANG00000005350|UniProtKB=F6X852	Uncharacterized protein	ISS	10428031	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	MONDO|Ensembl=ENSMODG00000019001|UniProtKB=F7CP86	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00060	Ubiquitin proteasome pathway	P01490	E3	MOUSE|MGI=MGI=1861728|UniProtKB=Q8BZZ3	NEDD4-like E3 ubiquitin-protein ligase WWP1	ISS			PTHR11254:SF299	NEDD4-LIKE E3 UBIQUITIN-PROTEIN LIGASE WWP1
P04393	Ras Pathway	P04553	PAK	HUMAN|HGNC=8591|UniProtKB=Q13177	Serine/threonine-protein kinase PAK 2	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ORYSJ|EnsemblGenome=OS10G0510000|UniProtKB=A3C6D7	Actin-2	IC	11889126	PubMed	PTHR11937:SF252	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00006	Apoptosis signaling pathway	P00269	MAPK	ORYSJ|EnsemblGenome=OS06G0699400|UniProtKB=Q5Z859	Mitogen-activated protein kinase 4	ISS	11707292	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00006	Apoptosis signaling pathway	P00318	PKCs	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00368	vav	BOVIN|Ensembl=ENSBTAG00000031575|UniProtKB=E1BBD2	Uncharacterized protein	ISS	14623913	PubMed	PTHR22826:SF97	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00037	Ionotropic glutamate receptor pathway	P01026	KA	CHICK|Ensembl=ENSGALG00000015835|UniProtKB=F1NZT2	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	RAT|RGD=620577|UniProtKB=Q62636	Ras-related protein Rap-1b	IDA	8576107	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00048	PI3 kinase pathway	P01200	SHIP	RAT|RGD=68396|UniProtKB=Q9WVR3	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	IDA	10381377	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05913	Enkephalin release	G06046	preproenkephalin mRNA	MOUSE|MGI=MGI=97535|UniProtKB=O35417	Proenkephalin-B	ISS	131330	OMIM	PTHR11438:SF4	PROENKEPHALIN-B
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	ARATH|TAIR=AT3G19420|UniProtKB=Q9LT75	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN2A	ISS			PTHR12305:SF32	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE TPTE2-RELATED
P06587	Nicotine pharmacodynamics pathway	P06605	KCNK3/9	MONDO|Ensembl=ENSMODG00000015769|UniProtKB=F6ZSC2	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00005	Angiogenesis	P00203	Erk	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	RCA	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	HUMAN|HGNC=5975|UniProtKB=Q14627	Interleukin-13 receptor subunit alpha-2	IDA	12816724	PubMed	PTHR23036:SF101	INTERLEUKIN-13 RECEPTOR SUBUNIT ALPHA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000000261|UniProtKB=F6X9C0	Adenosine receptor A2	ISS			PTHR24246:SF27	ADENOSINE RECEPTOR A2A
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00924	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01443	Phospholipase C	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PHYPA|Gene=PHYPADRAFT_225906|UniProtKB=A9TVP1	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MACMU|Ensembl=ENSMMUG00000004886|UniProtKB=F7AGT9	Uncharacterized protein	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	YEAST|SGD=S000000028|UniProtKB=P31109	Synaptobrevin homolog 1	IC			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00964	p90RSK	CHICK|Ensembl=ENSGALG00000016406|UniProtKB=F1NLJ3	Uncharacterized protein	ISS	10558991	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00010	B cell activation	P00379	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2051|UniProtKB=P28647	Adenosine receptor A3	ISS	11781138	PubMed	PTHR24246:SF2	ADENOSINE RECEPTOR A3
P00019	Endothelin signaling pathway	P00590	IP3 R	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	IGI	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00021	FGF signaling pathway	P00629	PP2A	YEAST|SGD=S000002205|UniProtKB=P20604	Serine/threonine-protein phosphatase PP1-1	ISS			PTHR11668:SF24	SERINE/THREONINE-PROTEIN PHOSPHATASE 6 CATALYTIC SUBUNIT
P00010	B cell activation	P00372	Grb2	MACMU|Ensembl=ENSMMUG00000005327|UniProtKB=F7GJG7	GRB2-related adapter protein	ISS			PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P00059	p53 pathway	P01480	PTEN	XENTR|Xenbase=XB-GENE-491433|UniProtKB=B1H2U0	Pten protein	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00059	p53 pathway	P04623	CBP	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P05918	p38 MAPK pathway	P06020	p38delta	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00036	Interleukin signaling pathway	P00983	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	TAS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00318	PKCs	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00036	Interleukin signaling pathway	P00975	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	MONDO|Ensembl=ENSMODG00000019823|UniProtKB=F6SB23	Uncharacterized protein (Fragment)	ISS	96032356	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	RAT|RGD=2736|UniProtKB=P35439	Glutamate receptor ionotropic, NMDA 1	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00047	PDGF signaling pathway	P01149	MNK1/2	HUMAN|HGNC=7110|UniProtKB=Q9BUB5	MAP kinase-interacting serine/threonine-protein kinase 1	ISS	11575158	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00558	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	CHICK|Ensembl=ENSGALG00000011809|UniProtKB=F1NMB0	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00005	Angiogenesis	P00219	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00010	B cell activation	P00379	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00029	Huntington disease	P00810	GAPDH	DANRE|ZFIN=ZDB-GENE-020913-1|UniProtKB=Q5MJ86	Glyceraldehyde-3-phosphate dehydrogenase 2	ISS			PTHR10836:SF79	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE, TESTIS-SPECIFIC
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	IC	14698601	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MACMU|Gene=CCR8|UniProtKB=O97665	C-C chemokine receptor type 8	TAS	12009564	PubMed	PTHR10489:SF627	C-C CHEMOKINE RECEPTOR TYPE 8
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	MONDO|Ensembl=ENSMODG00000012414|UniProtKB=F6PMC9	Uncharacterized protein	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00053	T cell activation	P01337	B7	MACMU|Ensembl=ENSMMUG00000000912|UniProtKB=F6R7U3	Uncharacterized protein	ISS	7694363	PubMed	PTHR25466:SF2	T-LYMPHOCYTE ACTIVATION ANTIGEN CD86
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MOUSE|MGI=MGI=96276|UniProtKB=Q61224	5-hydroxytryptamine receptor 1D	ISS	11701344	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00857	IkappaB	MOUSE|MGI=MGI=104741|UniProtKB=Q9Z1E3	NF-kappa-B inhibitor alpha	ISS	10811867	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00005	Angiogenesis	P00223	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01457	GBeta	DICPU|Gene=DICPUDRAFT_93216|UniProtKB=F1A421	Guanine nucleotide-binding protein subunit beta	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	RAT|RGD=2246|UniProtKB=Q07652	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	14507926	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00053	T cell activation	P01300	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00217	STAT3	MOUSE|MGI=MGI=103038|UniProtKB=P42227	Signal transducer and activator of transcription 3	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00056	VEGF signaling pathway	P01409	cPLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00049	Parkinson disease	P01232	CASK	ANOGA|EnsemblGenome=AGAP001683|UniProtKB=A0NGZ6	AGAP001683-PA	IPI	11679592	PubMed	PTHR23122:SF7	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00049	Parkinson disease	P01242	Casein kinase I	DROME|FlyBase=FBgn0037325|UniProtKB=Q7JWT4	AT15039p	IDA	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00054	Toll receptor signaling pathway	P01356	ERK2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	PANTR|Gene=CHRM3|UniProtKB=Q9N2A4	Muscarinic acetylcholine receptor M3	IDA	8100450	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	ISS	10553940	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00057	Wnt signaling pathway	P01451	Galpha	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00029	Huntington disease	P00761	Truncated Htt	HUMAN|HGNC=4851|UniProtKB=P42858	Huntingtin	TAS	9462744	PubMed	PTHR10170:SF10	HUNTINGTIN
P00024	Glycolysis	P00679	Aldolase	MONDO|Ensembl=ENSMODG00000015696|UniProtKB=F7E0Q7	Fructose-bisphosphate aldolase	ISS	6086339	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P04393	Ras Pathway	P04547	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00054	Toll receptor signaling pathway	G01550	Gene trancription	CANLF|Ensembl=ENSCAFG00000013762|UniProtKB=Q8SPQ9	Cyclooxygenase 2	ISS	11861541	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	RAT|RGD=3381|UniProtKB=P62716	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	IGI	10851062	PubMed	PTHR24055:SF330	SUBFAMILY NOT NAMED
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	CANLF|Ensembl=ENSCAFG00000004381|UniProtKB=J9JH96	Uncharacterized protein	ISS	92317054	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00865	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	7680960	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P02751	Lysine biosynthesis	P03011	N-succinyldiaminopimelate  aminotransferase	SYNY3|EnsemblGenome=BAA17159|UniProtKB=P73133	Acetylornithine aminotransferase	ISS			PTHR11986:SF79	ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL
P00010	B cell activation	P00383	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IDA	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04397	p53 pathway by glucose deprivation	P04641	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BOVIN|Ensembl=ENSBTAG00000005714|UniProtKB=Q3ZC07	Actin, alpha cardiac muscle 1	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=1339711|UniProtKB=Q5SX40	Myosin-1	IC	89264452	PubMed	PTHR13140:SF484	MYOSIN-1
P00048	PI3 kinase pathway	P01177	P110ACT	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	IGI	10799299	PubMed	PTHR10048:SF14	PI-3 KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00642	MEK1-2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	RAT|RGD=3694|UniProtKB=Q01827	Synaptic vesicular amine transporter	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	CANLF|Ensembl=ENSCAFG00000011148|UniProtKB=J9P1Y8	Uncharacterized protein	ISS	9459445	PubMed	PTHR10845:SF170	REGULATOR OF G-PROTEIN SIGNALING 9
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00010	B cell activation	P00381	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	IGI	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00057	Wnt signaling pathway	P01448	CBP	CAEEL|WormBase=WBGene00009595|UniProtKB=Q7JMS5	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CANLF|Ensembl=ENSCAFG00000013179|UniProtKB=E2RPU9	Uncharacterized protein	ISS	11259487	PubMed	PTHR24229:SF11	NOCICEPTIN RECEPTOR
P00049	Parkinson disease	P01215	Syntaxin	CANLF|Ensembl=ENSCAFG00000000185|UniProtKB=E2R4Q2	Uncharacterized protein	ISS	10321247	PubMed	PTHR19957:SF90	SYNTAXIN-7
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	MACMU|Ensembl=ENSMMUG00000006200|UniProtKB=F7HNS7	Receptor protein serine/threonine kinase	ISS	10683140	PubMed	PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P00036	Interleukin signaling pathway	P00996	STAT	BOVIN|Gene=STAT5A|UniProtKB=Q95115	Signal transducer and activator of transcription 5A	IC	95188889	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P04393	Ras Pathway	P04542	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	IDA	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00047	PDGF signaling pathway	P01145	c-fos	MONDO|Ensembl=ENSMODG00000005927|UniProtKB=F6WX28	Uncharacterized protein	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00034	Integrin signalling pathway	P00913	Csk	MACMU|Ensembl=ENSMMUG00000015267|UniProtKB=F7GRP2	Tyrosine-protein kinase	ISS	12665526	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P02738	De novo purine biosynthesis	P02889	dGDP kinase	BACSU|EnsemblGenome=BSU22730|UniProtKB=P31103	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P05731	GABA-B receptor II signaling	P05760	AC	HUMAN|HGNC=236|UniProtKB=O95622	Adenylate cyclase type 5	ISS	92317082	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00047	PDGF signaling pathway	P01154	Ras	XENTR|Xenbase=XB-GENE-494548|UniProtKB=F7EC26	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	ARATH|TAIR=AT2G17700|UniProtKB=O22558	Serine/threonine-protein kinase STY8	ISS			PTHR44012:SF3	SERINE/THREONINE-PROTEIN KINASE STY17-RELATED
P00037	Ionotropic glutamate receptor pathway	P01021	Vglut	PANTR|Ensembl=ENSPTRG00000005344|UniProtKB=H2Q6P5	Uncharacterized protein	ISS	12815758	PubMed	PTHR11662:SF207	VESICULAR GLUTAMATE TRANSPORTER 3
P00018	EGF receptor signaling pathway	P00562	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CHICK|Ensembl=ENSGALG00000019382|UniProtKB=E1BWK1	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00034	Integrin signalling pathway	P00912	Arp2/3	MOUSE|MGI=MGI=1928896|UniProtKB=Q9R0Q6	Actin-related protein 2/3 complex subunit 1A	IPI	12932731	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00010	B cell activation	P00375	Calmodulin	TAKRU|Ensembl=ENSTRUG00000003442|UniProtKB=H2S6Q5	Uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF197	CALMODULIN-LIKE PROTEIN 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	IC	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00034	Integrin signalling pathway	P00945	Parvin	PANTR|Ensembl=ENSPTRG00000014480|UniProtKB=H2RD24	Uncharacterized protein	ISS	11331308	PubMed	PTHR12114:SF7	BETA-PARVIN
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00274	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IDA	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00059	p53 pathway	G01566	TSP1	XENTR|Xenbase=XB-GENE-486189|UniProtKB=F6XC33	Uncharacterized protein (Fragment)	ISS	7521539	PubMed	PTHR10199:SF78	THROMBOSPONDIN-1
P00021	FGF signaling pathway	P00633	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT4G36450|UniProtKB=O23236	Mitogen-activated protein kinase 14	IDA	9836510	gi	PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P00036	Interleukin signaling pathway	P00985	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00037	Ionotropic glutamate receptor pathway	P01026	KA	PANTR|Ensembl=ENSPTRG00000011042|UniProtKB=H2QGF5	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	HUMAN|HGNC=9554|UniProtKB=Q99460	26S proteasome non-ATPase regulatory subunit 1	ISS			PTHR10943:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1
P00012	Cadherin signaling pathway	P00470	F-actin	BOVIN|Gene=ACTG2|UniProtKB=Q5E9B5	Actin, gamma-enteric smooth muscle	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TRIAD|EnsemblGenome=TriadG56111|UniProtKB=B3RX77	Non-muscle actin 6.2	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02738	De novo purine biosynthesis	P02902	ADP reductase	ARATH|TAIR=AT2G21790|UniProtKB=Q9SJ20	Ribonucleoside-diphosphate reductase large subunit	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00048	PI3 kinase pathway	P01189	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	TAS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00059	p53 pathway	P04610	Cyclin E	CHICK|Gene=CCNE1|UniProtKB=P49707	G1/S-specific cyclin-E1	NAS	1705768	gi	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DANRE|ZFIN=ZDB-GENE-000322-1|UniProtKB=Q9I8V1	Actin, alpha 1, skeletal muscle	IC	10974003	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DANRE|ZFIN=ZDB-GENE-040426-1489|UniProtKB=Q6PHV0	Syntaxin 3A	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02755	Methylmalonyl pathway	P03034	Methylmalonyl-CoA mutase	MYCTU|EnsemblGenome=Rv1493|UniProtKB=P9WJK5	Probable methylmalonyl-CoA mutase large subunit	ISS			PTHR42710:SF1	METHYLMALONYL-COA MUTASE, MITOCHONDRIAL
P00052	TGF-beta signaling pathway	P01286	TGFbeta	CANLF|Ensembl=ENSCAFG00000003550|UniProtKB=E2QW13	Uncharacterized protein	ISS	9395284	PubMed	PTHR11848:SF133	INHIBIN BETA A CHAIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	IC	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	BOVIN|Ensembl=ENSBTAG00000005410|UniProtKB=O46470	Regulator of G-protein signaling 7	IDA	8756726	PubMed	PTHR10845:SF26	REGULATOR OF G-PROTEIN SIGNALING 7
P00018	EGF receptor signaling pathway	P00564	Rac	DICDI|dictyBase=DDB_G0277869|UniProtKB=P34144	Rho-related protein rac1A	IGI	94124042	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00018	EGF receptor signaling pathway	P00547	PP2A	MACMU|Ensembl=ENSMMUG00000013047|UniProtKB=F7H808	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MONDO|Ensembl=ENSMODG00000011628|UniProtKB=F6U132	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DICDI|dictyBase=DDB_G0289489|UniProtKB=P07828	Actin-18	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MONDO|Ensembl=ENSMODG00000020977|UniProtKB=F6S5B1	Uncharacterized protein (Fragment)	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00048	PI3 kinase pathway	P01199	Galpha	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00010	B cell activation	P00391	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00012	Cadherin signaling pathway	P00462	Casein kinase II	HUMAN|HGNC=2460|UniProtKB=P67870	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P04395	Vasopressin synthesis	P04589	Signal Peptidase	ARATH|TAIR=AT3G15710|UniProtKB=Q9LW08	Signal peptidase I	IC	2674115	PubMed	PTHR10806:SF6	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11
P04380	Cortocotropin releasing factor receptor signaling pathway	P04455	beta-endorphin	PANTR|Ensembl=ENSPTRG00000011721|UniProtKB=H2R8Y3	Uncharacterized protein	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02738	De novo purine biosynthesis	P02891	GDP kinase	HALSA|EnsemblGenome=VNG_1160G|UniProtKB=P61136	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00059	p53 pathway	P04609	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	IGI	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	BOVIN|Ensembl=ENSBTAG00000004775|UniProtKB=F1MBY1	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00018	EGF receptor signaling pathway	P00548	RKIP	ORYSJ|EnsemblGenome=OS06G0157500|UniProtKB=Q8VWH2	Protein HEADING DATE 3B	NAS			PTHR11362:SF9	PROTEIN FLOWERING LOCUS T-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01443	Phospholipase C	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00053	T cell activation	P01336	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00057	Wnt signaling pathway	P01465	Ggamma	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MACMU|Ensembl=ENSMMUG00000022347|UniProtKB=F6ZCH5	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00045	Notch signaling pathway	P01119	NIct	HUMAN|HGNC=7881|UniProtKB=P46531	Neurogenic locus notch homolog protein 1	IGI	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00047	PDGF signaling pathway	P01154	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	BOVIN|Gene=RGS2|UniProtKB=Q0P5H5	Regulator of G-protein signaling 2	ISS	8756726	PubMed	PTHR10845:SF43	REGULATOR OF G-PROTEIN SIGNALING 2
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	DANRE|ZFIN=ZDB-GENE-030616-53|UniProtKB=Q71E60	AMPA receptor subunit GluR3B	ISS	12871085	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	PANTR|Ensembl=ENSPTRG00000014563|UniProtKB=H2QLZ0	Uncharacterized protein	ISS	1732409	PubMed	PTHR23036:SF17	INTERLEUKIN-5 RECEPTOR SUBUNIT ALPHA
P00029	Huntington disease	P00777	CBP	MACMU|Ensembl=ENSMMUG00000000893|UniProtKB=F6T7D0	Histone acetyltransferase p300	ISS	10823891	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00053	T cell activation	P01332	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IDA	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CAEBR|Gene=CBG02401|UniProtKB=A8WUE7	Protein CBR-NMR-1	ISS	11554554	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MONDO|Ensembl=ENSMODG00000019755|UniProtKB=F6WN64	Actin-related protein 2/3 complex subunit 5	ISS	12473693	PubMed	PTHR12644:SF2	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5-LIKE PROTEIN
P00010	B cell activation	P00371	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04397	p53 pathway by glucose deprivation	P04641	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00550	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12748278	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	PANTR|Ensembl=ENSPTRG00000017391|UniProtKB=D3K5P1	Adrenergic, beta-2-, receptor, surface	ISS	7669252	PubMed	PTHR24248:SF21	BETA-2 ADRENERGIC RECEPTOR
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00629	PP2A	MACMU|Ensembl=ENSMMUG00000013416|UniProtKB=F6Z2Q9	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B	ISS	12191994	PubMed	PTHR11871:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B GAMMA ISOFORM
P00012	Cadherin signaling pathway	P00474	Wnt	DANRE|ZFIN=ZDB-GENE-980526-416|UniProtKB=Q92048	Protein Wnt-2	IDA	8717036	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=2150308|UniProtKB=Q8K4D7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1	ISS	12860966	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P00053	T cell activation	P01324	rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00019	Endothelin signaling pathway	P00586	Gq	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	PANTR|Ensembl=ENSPTRG00000004701|UniProtKB=H2Q5G9	Low density lipoprotein receptor-related protein 6	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TRIVA|Gene=TVAG_512800|UniProtKB=A2HNG1	Actin (Fragment)	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00048	PI3 kinase pathway	P01192	p110	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01275	P38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00562	p38	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	IGI	20451058	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04580	TRH Receptor	CANLF|Ensembl=ENSCAFG00000000717|UniProtKB=E2R0P6	Uncharacterized protein	ISS	14599121	PubMed	PTHR24243:SF115	THYROTROPIN-RELEASING HORMONE RECEPTOR
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	PLAF7|EnsemblGenome=PF13_0287|UniProtKB=Q8IDF6	Adenylosuccinate synthetase	IEP	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P05731	GABA-B receptor II signaling	P05752	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00029	Huntington disease	P00774	Dynein complex	CHICK|Ensembl=ENSGALG00000005522|UniProtKB=F1NRI4	Uncharacterized protein	ISS	9454836	PubMed	PTHR11886:SF35	DYNEIN LIGHT CHAIN 2, CYTOPLASMIC
P02742	Tetrahydrofolate biosynthesis	P02945	Dihydropteroate synthase	STRCO|Gene=CAB42751|UniProtKB=Q9X8H8	Dihydropteroate synthase	ISS			PTHR20941:SF1	FOLIC ACID SYNTHESIS PROTEIN FOL1
P00012	Cadherin signaling pathway	P00464	Fyn	TAKRU|Ensembl=ENSTRUG00000003538|UniProtKB=H2S7D1	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF242	TYROSINE-PROTEIN KINASE FYNB
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04553	PAK	CANLF|Ensembl=ENSCAFG00000004956|UniProtKB=E2REH3	Uncharacterized protein	ISS	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00048	PI3 kinase pathway	P01185	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS			PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MOUSE|MGI=MGI=95823|UniProtKB=Q03391	Glutamate receptor ionotropic, NMDA 2D	IC	11554549	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	RAT|RGD=1305581|UniProtKB=B2RYB8	Integrin beta	ISS	10330002	PubMed	PTHR10082:SF15	INTEGRIN BETA-2
P00036	Interleukin signaling pathway	P00977	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IC	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01188	Gbetagamma	DICPU|Gene=DICPUDRAFT_93216|UniProtKB=F1A421	Guanine nucleotide-binding protein subunit beta	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00020	FAS signaling pathway	P00600	PARP	PANTR|Ensembl=ENSPTRG00000005711|UniProtKB=H2Q7A7	Poly [ADP-ribose] polymerase	ISS	12101391	PubMed	PTHR10338:SF127	POLY  ADP-RIBOSE  POLYMERASE 4
P00029	Huntington disease	P00796	Kainate receptor	PANTR|Gene=GRIK4|UniProtKB=Q5IS46	Glutamate receptor ionotropic, kainate 4	ISS	12778120	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00029	Huntington disease	P00775	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02734	Chorismate biosynthesis	P02872	3-Dehydroquinate synthase	YEAST|SGD=S000002534|UniProtKB=P08566	Pentafunctional AROM polypeptide	ISS			PTHR21090:SF5	PENTAFUNCTIONAL AROM POLYPEPTIDE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00023	General transcription regulation	P00660	RNA Polymerase II	CAEEL|WormBase=WBGene00017830|UniProtKB=Q19826	Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3	ISS	606023	OMIM	PTHR10917:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3
P00017	DNA replication	P00527	Histones	MACMU|Ensembl=ENSMMUG00000032235|UniProtKB=H9H5I5	Histone H3	ISS	20448842	PubMed	PTHR11426:SF179	HISTONE H3.3
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IGI	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00034	Integrin signalling pathway	P00925	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01026	KA	BOVIN|Ensembl=ENSBTAG00000009269|UniProtKB=F1MCM2	Uncharacterized protein	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	SCLS1|EnsemblGenome=SS1G_13801|UniProtKB=A7F871	Uncharacterized protein	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00030	Hypoxia response via HIF activation	P00819	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IPI	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	IDA	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P02738	De novo purine biosynthesis	P02891	GDP kinase	DEIRA|EnsemblGenome=DR_2499|UniProtKB=Q9RRJ1	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	MACMU|Ensembl=ENSMMUG00000017143|UniProtKB=F7H113	Uncharacterized protein	ISS	11907044	PubMed	PTHR44025:SF5	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	HUMAN|HGNC=13800|UniProtKB=Q9GZZ6	Neuronal acetylcholine receptor subunit alpha-10	IC			PTHR18945:SF768	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-10
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05924	AT1-R	RAT|RGD=2071|UniProtKB=P29089	Type-1B angiotensin II receptor	RCA			PTHR24228:SF32	TYPE-1B ANGIOTENSIN II RECEPTOR
P00021	FGF signaling pathway	P00638	PLCgamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04393	Ras Pathway	P04560	AP1	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00030	Hypoxia response via HIF activation	P00824	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	RCA	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	RCA	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00030	Hypoxia response via HIF activation	P00820	HIF-1beta	BOVIN|Gene=ARNT|UniProtKB=Q9BE97	Aryl hydrocarbon receptor nuclear translocator	ISS	7836384	PubMed	PTHR23042:SF50	ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR
P00029	Huntington disease	P00790	beta-Tubulin	ORYSJ|EnsemblGenome=OS01G0282800|UniProtKB=Q43594	Tubulin beta-1 chain	TAS	12932731	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P00046	Oxidative stress response	P01131	MKP5	DROME|FlyBase=FBgn0083992|UniProtKB=Q9NGL1	MAP kinase phosphatase-1	ISS			PTHR10159:SF402	DUAL SPECIFICITY PROTEIN PHOSPHATASE 19
P04398	p53 pathway feedback loops 2	P04657	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	IC	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01448	CBP	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	12885769	PubMed	PTHR10202:SF13	PRESENILIN-2
P00049	Parkinson disease	P01211	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00053	T cell activation	P01322	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00264	c-IAP1,2	CHICK|Gene=ITA|UniProtKB=Q90660	Inhibitor of apoptosis protein	ISS			PTHR10044:SF79	BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MONDO|Ensembl=ENSMODG00000007084|UniProtKB=F6UEK4	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF26	REGULATOR OF G-PROTEIN SIGNALING 7
P00047	PDGF signaling pathway	P01148	Grb2	MACMU|Ensembl=ENSMMUG00000005327|UniProtKB=F7GJG7	GRB2-related adapter protein	ISS	8051109	PubMed	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	RAT|RGD=2035|UniProtKB=Q03343	Adenylate cyclase type 6	IC	2491850	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00006	Apoptosis signaling pathway	P00286	AIF	BOVIN|Ensembl=ENSBTAG00000006838|UniProtKB=E1BJA2	Uncharacterized protein	ISS	9989411	PubMed	PTHR43557:SF4	APOPTOSIS-INDUCING FACTOR 1, MITOCHONDRIAL
P00012	Cadherin signaling pathway	P00465	TCF/LEF	HUMAN|HGNC=11640|UniProtKB=Q9HCS4	Transcription factor 7-like 1	ISS	12356903	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00029	Huntington disease	P00790	beta-Tubulin	DAPPU|EnsemblGenome=DAPPUDRAFT_300845|UniProtKB=E9HEX5	Putative uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF250	SUBFAMILY NOT NAMED
P02776	Serine glycine biosynthesis	P03160	Phosphoglycerate dehydrogenase	SULSO|EnsemblGenome=SSO0905|UniProtKB=Q97ZK1	D-3-phosphoglycerate dehydrogenase (SerA-1)	ISS			PTHR42938:SF9	FORMATE DEHYDROGENASE 1-RELATED
P00053	T cell activation	P01311	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IDA	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	7925653	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	DROME|FlyBase=FBgn0260798|UniProtKB=P32865	G protein-coupled receptor kinase 1	IDA	10852916	PubMed	PTHR24355:SF18	PROTEIN-SERINE/THREONINE KINASE
P02746	Heme biosynthesis	P02981	Glutamate-1-semialdehyde aminotransferase	ARATH|TAIR=AT5G63570|UniProtKB=P42799	Glutamate-1-semialdehyde 2,1-aminomutase 1, chloroplastic	ISS			PTHR43713:SF2	GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE 1, CHLOROPLASTIC-RELATED
P00053	T cell activation	P01331	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IDA	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00057	Wnt signaling pathway	P01444	Wnt	TAKRU|Ensembl=ENSTRUG00000017138|UniProtKB=H2V3X9	Protein Wnt	IDA	11266476	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MONDO|Ensembl=ENSMODG00000004799|UniProtKB=F6VM87	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00049	Parkinson disease	P01211	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	IC	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00045	Notch signaling pathway	P01101	Su(H)	PANTR|Ensembl=ENSPTRG00000013542|UniProtKB=H2QKF3	Uncharacterized protein	ISS			PTHR10665:SF2	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS-LIKE PROTEIN
P00029	Huntington disease	P00774	Dynein complex	TAKRU|Ensembl=ENSTRUG00000016434|UniProtKB=H2UYP9	Uncharacterized protein	ISS	9454836	PubMed	PTHR11886:SF62	DYNEIN, LIGHT CHAIN, LC8-TYPE 2
P00034	Integrin signalling pathway	P00928	alpha actinin	ORNAN|Ensembl=ENSOANG00000009397|UniProtKB=F7F6L1	Uncharacterized protein	ISS	2116421	PubMed	PTHR43947:SF4	ALPHA-ACTININ-2
P00018	EGF receptor signaling pathway	P00539	14-3-3	BOVIN|Gene=YWHAG|UniProtKB=P68252	14-3-3 protein gamma	ISS	10407019	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00060	Ubiquitin proteasome pathway	P01490	E3	BOVIN|Ensembl=ENSBTAG00000007118|UniProtKB=F1MLS5	Uncharacterized protein	ISS	11252892	PubMed	PTHR11254:SF293	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	IC	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00056	VEGF signaling pathway	P01407	Erk	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	HUMAN|HGNC=10941|UniProtKB=P43003	Excitatory amino acid transporter 1	ISS	94365697	PubMed	PTHR11958:SF24	EXCITATORY AMINO ACID TRANSPORTER 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	TAKRU|Ensembl=ENSTRUG00000014690|UniProtKB=H2UKR9	Uncharacterized protein	IDA	2137198	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00024	Glycolysis	P00679	Aldolase	PANTR|Gene=ALDOA|UniProtKB=A5A6I5	Fructose-bisphosphate aldolase A	ISS	74094688	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	PSEAE|EnsemblGenome=PA0350|UniProtKB=Q9I6E3	Dihydrofolate reductase	ISS			PTHR22778:SF16	DIHYDROFOLATE REDUCTASE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04393	Ras Pathway	P04559	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12932731	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00011	Blood coagulation	P00413	HMWK	HUMAN|HGNC=6383|UniProtKB=P01042	Kininogen-1	ISS	125507	gi	PTHR13814:SF12	KININOGEN-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IC	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00059	p53 pathway	P04623	CBP	PANTR|Ensembl=ENSPTRG00000014418|UniProtKB=H2QLS0	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00011	Blood coagulation	P00453	FXIII	MOUSE|MGI=MGI=1921395|UniProtKB=Q8BH61	Coagulation factor XIII A chain	ISS	11067435	gi	PTHR11590:SF42	COAGULATION FACTOR XIII A CHAIN
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	DROME|FlyBase=FBgn0001123|UniProtKB=P20354	G protein alpha s subunit	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	PANTR|Ensembl=ENSPTRG00000002706|UniProtKB=H2Q272	Receptor protein serine/threonine kinase	ISS	10683140	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00010	B cell activation	P00371	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00561	STAT	RAT|RGD=1309063|UniProtKB=Q1KQ07	Signal transducer and activator of transcription	ISS	14598258	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PHYPA|Gene=PHYPADRAFT_117822|UniProtKB=A9RQS1	Predicted protein	ISS	9454836	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00029	Huntington disease	P00796	Kainate receptor	HUMAN|HGNC=4579|UniProtKB=P39086	Glutamate receptor ionotropic, kainate 1	IDA	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P06587	Nicotine pharmacodynamics pathway	P06593	CHRNA5	MOUSE|MGI=MGI=87889|UniProtKB=Q2MKA5	Neuronal acetylcholine receptor subunit alpha-5	ISS	12388584	PubMed	PTHR18945:SF76	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00010	B cell activation	P00369	MEKK	MACMU|Ensembl=ENSMMUG00000018568|UniProtKB=F6YLW2	Uncharacterized protein	ISS	8621389	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00005	Angiogenesis	P00193	SOS-1	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02744	Fructose galactose metabolism	P02960	Galactokinase	BOVIN|Gene=GALK1|UniProtKB=A6H768	Galactokinase	ISS	12003984	gi	PTHR10457:SF6	GALACTOKINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Gene=PLCD4|UniProtKB=P21671	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	12860966	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00057	Wnt signaling pathway	P01428	Frizzled	RAT|RGD=628816|UniProtKB=G3V6L1	Frizzled homolog 6 (Drosophila)	ISS	11212302	PubMed	PTHR11309:SF75	FRIZZLED-6
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04398	p53 pathway feedback loops 2	P04662	cyclin G	MACMU|Ensembl=ENSMMUG00000019550|UniProtKB=F7CKQ1	Uncharacterized protein	ISS	7957050	PubMed	PTHR10177:SF59	CYCLIN-G1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	DANRE|ZFIN=ZDB-GENE-020604-1|UniProtKB=Q6IQX1	Myosin, heavy polypeptide 2, fast muscle specific	ISS	10938134	PubMed	PTHR13140:SF676	MYOSIN, HEAVY POLYPEPTIDE 2, FAST MUSCLE SPECIFIC
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04376	5HT4 type receptor mediated signaling pathway	P04426	K+ channel	RAT|RGD=621451|UniProtKB=Q9ES08	Potassium channel subfamily K member 9	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00015	Circadian clock system	G01503	per	PANTR|Ensembl=ENSPTRG00000008726|UniProtKB=H2QC70	Uncharacterized protein	ISS	12782655	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	MONDO|Ensembl=ENSMODG00000003229|UniProtKB=F6TYA8	Uncharacterized protein (Fragment)	ISS	10409711	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347740|UniProtKB=E9FXV8	Cytoplasmatic actin	ISS	10974003	PubMed	PTHR11937:SF277	SUBFAMILY NOT NAMED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00049	Parkinson disease	P01242	Casein kinase I	SCHPO|PomBase=SPAC1805.05|UniProtKB=O74135	Casein kinase I homolog 3	IDA	10617630	PubMed	PTHR11909:SF155	GILGAMESH, ISOFORM L
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	IC	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00047	PDGF signaling pathway	P01143	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00907	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00565	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04398	p53 pathway feedback loops 2	P04665	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00470	F-actin	MACMU|Ensembl=ENSMMUG00000017683|UniProtKB=F6UA63	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	BRAFL|Gene=BRAFLDRAFT_123893|UniProtKB=C3XQF4	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IDA	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	10693759	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P02725	Allantoin degradation	P02821	Allantoate amidohydrolase	SCHPO|PomBase=SPAC1F7.09c|UniProtKB=Q09913	Probable allantoicase	ISS			PTHR12045:SF3	ALLANTOICASE-RELATED
P05916	Opioid prodynorphin pathway	P06002	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00052	TGF-beta signaling pathway	P01275	P38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00053	T cell activation	P01307	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00022	General transcription by RNA polymerase I	P00649	TAF-IC	DANRE|ZFIN=ZDB-GENE-040426-1013|UniProtKB=Q6P0T2	Transcription initiation factor TFIID subunit 8	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00049	Parkinson disease	P01219	SAPK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06831	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	RCA	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00010	B cell activation	P00384	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04395	Vasopressin synthesis	P04593	Glycopeptide	HUMAN|HGNC=8528|UniProtKB=P01178	Oxytocin-neurophysin 1	IC	192340	OMIM	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00016	Cytoskeletal regulation by Rho GTPase	P00520	Rho GAPs	DROME|FlyBase=FBgn0036257|UniProtKB=Q9VTU3	Rho GTPase-activating protein 68F	ISS			PTHR23176:SF0	RHO GTPASE-ACTIVATING PROTEIN 68F
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04496	Mdm2	HUMAN|HGNC=6973|UniProtKB=Q00987	E3 ubiquitin-protein ligase Mdm2	IGI	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00030	Hypoxia response via HIF activation	P00819	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IDA	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05915	Opioid proenkephalin pathway	P05994	G-protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00010	B cell activation	P00373	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04393	Ras Pathway	P04558	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02785	Valine biosynthesis	P03216	Acetolactate synthase	AQUAE|EnsemblGenome=aq_451|UniProtKB=O66759	Acetolactate synthase	ISS			PTHR18968:SF116	ACETOLACTATE SYNTHASE ISOZYME 3 LARGE SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9441|UniProtKB=P51817	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IDA	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	RAT|RGD=3133|UniProtKB=P23999	Protein S-Myc	IEP	12356903	PubMed	PTHR11514:SF4	PROTEIN S-MYC
P00054	Toll receptor signaling pathway	P01358	ERK1	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05730	Endogenous cannabinoid signaling	P05748	mGluR	CANLF|Ensembl=ENSCAFG00000004381|UniProtKB=J9JH96	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	XENTR|GeneID=394982|UniProtKB=P20399	Actin, alpha cardiac muscle 2	ISS	11889126	PubMed	PTHR11937:SF263	ACTIN
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P06959	CCKR signaling map	P07155	CDC42-GTP	HUMAN|HGNC=1736|UniProtKB=P60953	Cell division control protein 42 homolog	RCA	18565785	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MONDO|Ensembl=ENSMODG00000001389|UniProtKB=F7BD45	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF657	MYOSIN-4
P00005	Angiogenesis	P00203	Erk	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00912	Arp2/3	CANLF|Ensembl=ENSCAFG00000015081|UniProtKB=E2RMT4	Uncharacterized protein	ISS	9618202	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	RAT|RGD=619729|UniProtKB=O88204	Low-density lipoprotein receptor-related protein 3	IDA	11907044	PubMed	PTHR44062:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 3
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	HUMAN|HGNC=11551|UniProtKB=Q92994	Transcription factor IIIB 90 kDa subunit	ISS			PTHR11618:SF4	TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00010	B cell activation	P00384	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	IDA	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	BOVIN|Ensembl=ENSBTAG00000014674|UniProtKB=P41985	Muscarinic acetylcholine receptor M2	ISS	12181435	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04395	Vasopressin synthesis	P04594	Neurophysin	DANRE|ZFIN=ZDB-GENE-030407-1|UniProtKB=F1QC27	Uncharacterized protein	ISS			PTHR11681:SF14	SUBFAMILY NOT NAMED
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00017	DNA replication	P00537	RPA	HUMAN|HGNC=10290|UniProtKB=P15927	Replication protein A 32 kDa subunit	IDA	11731442	PubMed	PTHR13989:SF10	REPLICATION PROTEIN A 32 KDA SUBUNIT
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=1921305|UniProtKB=Q8K4S1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	12176394	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00010	B cell activation	P00385	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	10891487	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00019	Endothelin signaling pathway	P00587	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	BOVIN|Ensembl=ENSBTAG00000011256|UniProtKB=A6QLD6	MYO1B protein	ISS			PTHR13140:SF277	UNCONVENTIONAL MYOSIN-IB
P02775	Salvage pyrimidine ribonucleotides	P03155	Cytosine deaminase	PANTR|Ensembl=ENSPTRG00000018669|UniProtKB=H2QTU8	Adenosine deaminase, tRNA-specific 2, TAD2 homolog	ISS			PTHR11079:SF92	TRNA-SPECIFIC ADENOSINE DEAMINASE 2
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IDA	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	ISS	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00005	Angiogenesis	P00210	eNOS	CANLF|Gene=NOS3|UniProtKB=Q9TUX8	Nitric oxide synthase, endothelial	ISS	93055452	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00020	FAS signaling pathway	P00611	Gelsolin	PANTR|Ensembl=ENSPTRG00000012132|UniProtKB=H2QI91	Uncharacterized protein	ISS	9323209	PubMed	PTHR11977:SF13	MACROPHAGE-CAPPING PROTEIN
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	HUMAN|HGNC=2514|UniProtKB=P35222	Catenin beta-1	IDA	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	RAT|RGD=2026|UniProtKB=P68035	Actin, alpha cardiac muscle 1	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=88399|UniProtKB=P32211	Muscarinic acetylcholine receptor M4	IDA	10069496	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00019	Endothelin signaling pathway	P00590	IP3 R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00047	PDGF signaling pathway	P01142	p90RSK	CHICK|Ensembl=ENSGALG00000005198|UniProtKB=F1P4J0	Ribosomal protein S6 kinase	ISS	15116068	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00021	FGF signaling pathway	P00627	ERK1-2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	8387895	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00060	Ubiquitin proteasome pathway	P01491	E2	BOVIN|Ensembl=ENSBTAG00000004161|UniProtKB=Q1RMX2	Ubiquitin-conjugating enzyme E2 D2	ISS			PTHR24068:SF40	UBIQUITIN-CONJUGATING ENZYME E2 D2-RELATED
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	NEUCR|EnsemblGenome=EFNCRG00000001712|UniProtKB=Q1K5K1	DNA-directed RNA polymerase II polypeptide	ISS	2187864	PubMed	PTHR11800:SF2	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00049	Parkinson disease	P01226	CDCrel-1	DROME|FlyBase=FBgn0011710|UniProtKB=P42207	Septin-1	IDA			PTHR18884:SF67	SEPTIN-2
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PANTR|Ensembl=ENSPTRG00000018890|UniProtKB=Q5R1X3	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00021	FGF signaling pathway	P00629	PP2A	MOUSE|MGI=MGI=1321161|UniProtKB=P62715	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04398	p53 pathway feedback loops 2	P04665	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MOUSE|MGI=MGI=1339710|UniProtKB=G3UW82	MCG140437, isoform CRA_d	IEP	89264452	PubMed	PTHR13140:SF385	MYOSIN-2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02747	Histidine biosynthesis	P02993	Phosphoribosylformimino-5-amino-1-phosphoribosyl-4 imadazol carboxamide isomerase	METAC|EnsemblGenome=MA_0218|UniProtKB=Q8TU55	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase	ISS			PTHR43090:SF2	1- 5-PHOSPHORIBOSYL -5-  5-PHOSPHORIBOSYLAMINO METHYLIDENEAMINO  IMIDAZOLE-4-CARBOXAMIDE ISOMERASE
P00006	Apoptosis signaling pathway	P00269	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04393	Ras Pathway	P04542	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CAEEL|WormBase=WBGene00003774|UniProtKB=G5EGQ9	NMDA class glutamate Receptor	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00056	VEGF signaling pathway	P01413	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	DROME|FlyBase=FBgn0003716|UniProtKB=Q9VMT1	Receptor protein serine/threonine kinase	TAS	9395284	PubMed	PTHR23255:SF68	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00029	Huntington disease	P00795	BDNF	BOVIN|Ensembl=ENSBTAG00000008134|UniProtKB=Q95106	Brain-derived neurotrophic factor	ISS	11408619	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P02772	Pyruvate metabolism	P03140	Pyruvate Carboxylase	YEAST|SGD=S000000422|UniProtKB=P32327	Pyruvate carboxylase 2	IDA	1921979	PubMed	PTHR43778:SF2	PYRUVATE CARBOXYLASE, MITOCHONDRIAL
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	CAEBR|Gene=CBG18000|UniProtKB=A8XSS7	Protein CBR-ACY-1	ISS	22013858	PubMed	PTHR11920:SF319	ADENYLATE CYCLASE TYPE 9
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	MOUSE|MGI=MGI=97364|UniProtKB=O35516	Neurogenic locus notch homolog protein 2	IDA	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	IDA	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00034	Integrin signalling pathway	P00924	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00053	T cell activation	P01336	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00034	Integrin signalling pathway	P00920	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04393	Ras Pathway	P04556	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	MONDO|Ensembl=ENSMODG00000004410|UniProtKB=F6SV58	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF322	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	YEAST|SGD=S000003272|UniProtKB=P14681	Mitogen-activated protein kinase KSS1	TAS			PTHR24055:SF338	MITOGEN-ACTIVATED PROTEIN KINASE KSS1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00004	Alzheimer disease-presenilin pathway	P00126	Fe65	MOUSE|MGI=MGI=107765|UniProtKB=Q9QXJ1	Amyloid beta A4 precursor protein-binding family B member 1	IDA	11441186	PubMed	PTHR14058:SF5	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1
P00018	EGF receptor signaling pathway	P00562	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00054	Toll receptor signaling pathway	P01361	TBK1	HUMAN|HGNC=11584|UniProtKB=Q9UHD2	Serine/threonine-protein kinase TBK1	ISS			PTHR22969:SF14	SERINE/THREONINE-PROTEIN KINASE TBK1
P00056	VEGF signaling pathway	P01408	Akt/PKB	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01307	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02744	Fructose galactose metabolism	P02966	Hexokinase	RAT|RGD=2797|UniProtKB=P27881	Hexokinase-2	RCA			PTHR19443:SF4	HEXOKINASE-2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	DROME|FlyBase=FBgn0032001|UniProtKB=Q9VLR3	CG8360, isoform A	ISS			PTHR11644:SF2	CYTIDINE DEAMINASE
P00005	Angiogenesis	P00190	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	8270251	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00057	Wnt signaling pathway	P01438	PP2A	HUMAN|HGNC=9310|UniProtKB=Q15173	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform	IDA	11531413	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00990	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00059	p53 pathway	P04634	Cdc2	TRYB2|Gene=Tb10.70.2210|UniProtKB=Q38BA2	Cell division related protein kinase 2, putative	ISS			PTHR24056:SF184	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	9298898	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00558	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	176910	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	HUMAN|HGNC=23212|UniProtKB=Q7Z406	Myosin-14	ISS	89264452	PubMed	PTHR13140:SF462	MYOSIN-14
P04393	Ras Pathway	P04558	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	IDA	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MACMU|Ensembl=ENSMMUG00000021231|UniProtKB=F6UHJ9	Uncharacterized protein	ISS			PTHR13140:SF345	UNCONVENTIONAL MYOSIN-XVI
P00036	Interleukin signaling pathway	P00990	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00035	Interferon-gamma signaling pathway	P00960	PTP	CANLF|Ensembl=ENSCAFG00000008894|UniProtKB=F1Q3J6	Tyrosine-protein phosphatase non-receptor type	ISS	95163101	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P04395	Vasopressin synthesis	P04589	Signal Peptidase	DICDI|dictyBase=DDB_G0276359|UniProtKB=Q86JD4	Signal peptidase complex catalytic subunit sec11	IC	2674115	PubMed	PTHR10806:SF6	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11
P02728	Arginine biosynthesis	P02841	argininosuccinate lyase	CHICK|Ensembl=ENSGALG00000002558|UniProtKB=P02521	Delta-1 crystallin	ISS			PTHR43814:SF1	ARGININOSUCCINATE LYASE
P00005	Angiogenesis	P00226	Delta/Serrate	CHICK|Ensembl=ENSGALG00000011696|UniProtKB=F1NMD6	Delta-like protein	ISS	9032054	PubMed	PTHR44097:SF1	PROTEIN JAGGED-2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	CAEEL|WormBase=WBGene00002173|UniProtKB=Q9Y0A1	Inositol 1,4,5-trisphosphate receptor itr-1	IDA	4262086	gi	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00059	p53 pathway	G04690	PAG608	BOVIN|Ensembl=ENSBTAG00000012463|UniProtKB=Q0IIC4	Zinc finger matrin-type protein 3	ISS			PTHR23067:SF5	ZINC FINGER MATRIN-TYPE PROTEIN 3
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	MOUSE|MGI=MGI=104644|UniProtKB=Q60819	Interleukin-15 receptor subunit alpha	IPI	7641685	PubMed	PTHR15060:SF0	INTERLEUKIN-15 RECEPTOR SUBUNIT ALPHA
P00021	FGF signaling pathway	P00648	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P06959	CCKR signaling map	P07098	p46 SHC1	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	RCA	8549807	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00029	Huntington disease	P00775	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	TAS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02736	Coenzyme A biosynthesis	P02883	Pantothenoylcysteine decarboxylase	BACTN|EnsemblGenome=BT_1362|UniProtKB=Q8A812	Flavoprotein	ISS			PTHR14359:SF6	PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE
P00053	T cell activation	P01312	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00049	Parkinson disease	P01212	p38 MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04398	p53 pathway feedback loops 2	P04657	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00243	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00057	Wnt signaling pathway	P01438	PP2A	CHICK|Ensembl=ENSGALG00000010273|UniProtKB=P48463	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	IDA	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00059	p53 pathway	G04694	p110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00046	Oxidative stress response	P01129	JNK1/2	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02785	Valine biosynthesis	P03215	Branched chain amino acid aminotransferase	PANTR|Ensembl=ENSPTRG00000004772|UniProtKB=H2Q5L8	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF51	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, CYTOSOLIC
P00019	Endothelin signaling pathway	P00588	ET1-4	MACMU|Ensembl=ENSMMUG00000016214|UniProtKB=F7GJV6	Uncharacterized protein	ISS	12516960	PubMed	PTHR13874:SF9	ENDOTHELIN-2
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	ORNAN|Ensembl=ENSOANG00000003489|UniProtKB=F7FSE3	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02778	Sulfate assimilation	P03167	Sulfate adenylyltransferase	MOUSE|MGI=MGI=1330223|UniProtKB=O88428	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2	ISS			PTHR11055:SF16	BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE 2
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	8649368	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00052	TGF-beta signaling pathway	P01286	TGFbeta	BOVIN|Ensembl=ENSBTAG00000012004|UniProtKB=A6QP91	TGFB3 protein	ISS	9759503	PubMed	PTHR11848:SF34	TRANSFORMING GROWTH FACTOR BETA-3
P00059	p53 pathway	P04633	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000024992|UniProtKB=F6TUR3	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00015	Circadian clock system	G01497	cry	CHICK|Gene=CRY2|UniProtKB=Q8QG60	Cryptochrome-2	ISS			PTHR11455:SF15	CRYPTOCHROME-2
P00005	Angiogenesis	P00183	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	95096035	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	SCHPO|PomBase=SPBC16D10.10|UniProtKB=O94642	tRNA-specific adenosine deaminase subunit tad2	ISS			PTHR11079:SF92	TRNA-SPECIFIC ADENOSINE DEAMINASE 2
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	MONDO|Ensembl=ENSMODG00000018065|UniProtKB=F7G485	Uncharacterized protein	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00012	Cadherin signaling pathway	P00467	alpha-catenin	BOVIN|Ensembl=ENSBTAG00000045699|UniProtKB=G3N018	Uncharacterized protein	ISS	9362521	PubMed	PTHR18914:SF21	CATENIN ALPHA-3
P00004	Alzheimer disease-presenilin pathway	P00144	Ire-1	CANLF|Ensembl=ENSCAFG00000011784|UniProtKB=F1P7G9	Uncharacterized protein	ISS	10619423	PubMed	PTHR13954:SF17	SERINE/THREONINE-PROTEIN KINASE/ENDORIBONUCLEASE IRE1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05730	Endogenous cannabinoid signaling	P05751	Galpha	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	RCA	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00572	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00047	PDGF signaling pathway	P01153	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00029	Huntington disease	P00801	Fos protein	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	TAS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P06959	CCKR signaling map	P07188	RHOA-GTP	HUMAN|HGNC=667|UniProtKB=P61586	Transforming protein RhoA	RCA	19940064	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04393	Ras Pathway	P04552	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04395	Vasopressin synthesis	P04594	Neurophysin	DANRE|ZFIN=ZDB-GENE-030407-2|UniProtKB=F8W5D0	Uncharacterized protein (Fragment)	ISS			PTHR11681:SF13	SUBFAMILY NOT NAMED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00199	JNKK1	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P05914	Nicotine degradation	P05979	FMO3	MACMU|Gene=FMO3|UniProtKB=Q8SPQ7	Dimethylaniline monooxygenase [N-oxide-forming] 3	ISS	1446003	PubMed	PTHR23023:SF44	DIMETHYLANILINE MONOOXYGENASE  N-OXIDE-FORMING  3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	G04671	proopiomelanocortin	DANRE|ZFIN=ZDB-GENE-030513-2|UniProtKB=Q7ZT18	Pro-opiomelanocortin protein	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	STRPU|EnsemblGenome=SPU_026078|UniProtKB=W4ZD41	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF277	SUBFAMILY NOT NAMED
P00014	Cholesterol biosynthesis	P00498	Hydroxymethyl glutaryl CoA synthase	MONDO|Ensembl=ENSMODG00000020279|UniProtKB=F7C0S7	Uncharacterized protein	ISS	123332	gi	PTHR43323:SF4	HYDROXYMETHYLGLUTARYL-COA SYNTHASE, CYTOPLASMIC
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01457	GBeta	CAEEL|WormBase=WBGene00001679|UniProtKB=P17343	Guanine nucleotide-binding protein subunit beta-1	IDA	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00053	T cell activation	P01312	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05913	Enkephalin release	P05972	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MOUSE|MGI=MGI=102522|UniProtKB=Q8R3Z5	Voltage-dependent L-type calcium channel subunit beta-1	ISS	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P02777	Succinate to proprionate conversion	P03161	Methylmalonyl-CoA mutase	SULSO|EnsemblGenome=SSO2425|UniProtKB=Q97W21	Methylmalonyl-CoA mutase, alpha-subunit, chain A (McmA1)	ISS			PTHR43589:SF2	SUBFAMILY NOT NAMED
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00010	B cell activation	P00369	MEKK	PANTR|Ensembl=ENSPTRG00000012427|UniProtKB=H2QIN7	Mitogen-activated protein kinase kinase kinase 2	ISS	8649450	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00029	Huntington disease	P00785	Cytochrome c	CANLF|Ensembl=ENSCAFG00000001529|UniProtKB=E2REM0	Uncharacterized protein	ISS	15163634	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00060	Ubiquitin proteasome pathway	P01490	E3	SCHPO|PomBase=SPAC19D5.04|UniProtKB=O13834	E3 ubiquitin-protein ligase ptr1	ISS			PTHR11254:SF291	E3 UBIQUITIN-PROTEIN LIGASE HUWE1
P00021	FGF signaling pathway	P00633	Ras	CAEBR|Gene=CBG06092|UniProtKB=A8X0X5	Protein CBR-LET-60	ISS	22022015	PubMed	PTHR24070:SF385	GTPASE HRAS
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	RCA	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00012	Cadherin signaling pathway	P00464	Fyn	PANTR|Ensembl=ENSPTRG00000018511|UniProtKB=H2QTK7	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P04374	5HT2 type receptor mediated signaling pathway	P04413	K+ channel	MOUSE|MGI=MGI=3521816|UniProtKB=Q3LS21	Potassium channel subfamily K member 9	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02736	Coenzyme A biosynthesis	P02882	Pantothenate cysteine ligase	RHOBA|EnsemblGenome=RB7087|UniProtKB=Q7UP94	DNA/pantothenate metabolism flavoprotein	ISS			PTHR14359:SF6	PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00052	TGF-beta signaling pathway	P01284	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	SCHMA|EnsemblGenome=Smp_202970|UniProtKB=G4VLN1	Putative uncharacterized protein Smp_202970	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00254	GTPase	XENTR|Xenbase=XB-GENE-489222|UniProtKB=Q28GJ8	Ras homolog gene family, member A	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00019	Endothelin signaling pathway	P00573	signal peptidase	BOVIN|Ensembl=ENSBTAG00000011954|UniProtKB=Q2KI36	Signal peptidase complex catalytic subunit SEC11	ISS	2674115	PubMed	PTHR10806:SF12	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11C
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	CHICK|Ensembl=ENSGALG00000003267|UniProtKB=Q6DV79	Signal transducer and activator of transcription 3	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MACMU|Ensembl=ENSMMUG00000007027|UniProtKB=F7F210	Alpha-cardiac actin	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00005	Angiogenesis	P00221	JNK1	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IC	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00056	VEGF signaling pathway	P01417	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=98958|UniProtKB=P22725	Protein Wnt-5a	IDA	8717036	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00021	FGF signaling pathway	P00628	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00057	Wnt signaling pathway	P01428	Frizzled	PANTR|Ensembl=ENSPTRG00000029908|UniProtKB=H2R050	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF90	FRIZZLED-8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00022	General transcription by RNA polymerase I	P00650	TAF-IB	RAT|RGD=1308423|UniProtKB=D3ZY89	Protein Taf8	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00057	Wnt signaling pathway	P01440	Cadherin	CANLF|Ensembl=ENSCAFG00000004935|UniProtKB=F1P802	Uncharacterized protein	ISS	8120095	PubMed	PTHR43912:SF7	PROTOCADHERIN-20
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	2372396	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P06959	CCKR signaling map	P07053	IKBalpha	HUMAN|HGNC=7797|UniProtKB=P25963	NF-kappa-B inhibitor alpha	RCA	12740336	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000006307|UniProtKB=H2SSM1	Uncharacterized protein	IC			PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00019	Endothelin signaling pathway	P00591	PLCbeta	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00004	Alzheimer disease-presenilin pathway	P00145	CD44	MOUSE|MGI=MGI=88338|UniProtKB=P15379	CD44 antigen	IDA	12223485	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DANRE|ZFIN=ZDB-GENE-030131-1229|UniProtKB=Q6DHS1	Actin, alpha 2, smooth muscle, aorta	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00029	Huntington disease	P00805	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	IDA	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	10644715	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00003	Alzheimer disease-amyloid secretase pathway	P00084	X11alpha	CANLF|Ensembl=ENSCAFG00000001897|UniProtKB=E2RG71	Uncharacterized protein	ISS	9614075	PubMed	PTHR12345:SF14	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06849	Sos	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	RCA	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	HUMAN|HGNC=1402|UniProtKB=Q08289	Voltage-dependent L-type calcium channel subunit beta-2	IC	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00020	FAS signaling pathway	P00594	Caspase8	PANTR|Ensembl=ENSPTRG00000012801|UniProtKB=H2QJ86	Caspase 8, apoptosis-related cysteine peptidase	ISS	11917123	PubMed	PTHR10454:SF162	CASPASE-8
P00010	B cell activation	P00376	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	ARATH|TAIR=AT1G72710|UniProtKB=Q9CAI5	At1g72710	IDA	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4404|UniProtKB=P59768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01199	Galpha	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IC	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000008270|UniProtKB=H2QBE5	Uncharacterized protein	ISS	11953314	PubMed	PTHR24027:SF319	CADHERIN-1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00057	Wnt signaling pathway	P01447	Dishevelled	MONDO|Ensembl=ENSMODG00000006553|UniProtKB=F7BUW7	Uncharacterized protein	ISS	11212302	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00006	Apoptosis signaling pathway	P00310	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-040426-1693|UniProtKB=Q6P967	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	XENTR|Xenbase=XB-GENE-1010483|UniProtKB=F7AF72	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	XENTR|Ensembl=ENSXETG00000030140|UniProtKB=F7EP58	Uncharacterized protein (Fragment)	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00019	Endothelin signaling pathway	P00570	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02749	Leucine biosynthesis	P03000	Branched chain amino acid aminotransferase	ORYSJ|EnsemblGenome=OS05G0558400|UniProtKB=Q6AT43	Branched-chain-amino-acid aminotransferase	ISS			PTHR42825:SF3	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IDA	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00005	Angiogenesis	P00184	Src	HUMAN|HGNC=11283|UniProtKB=P12931	Proto-oncogene tyrosine-protein kinase Src	ISS	8054685	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	RAT|RGD=1304988|UniProtKB=A0A0G2K6Q8	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00641	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00057	Wnt signaling pathway	P01451	Galpha	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MONDO|Ensembl=ENSMODG00000016595|UniProtKB=F6ZDB2	Uncharacterized protein	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	BOVIN|Ensembl=ENSBTAG00000000219|UniProtKB=F1MCL3	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00059	p53 pathway	P01485	p53	MACMU|Ensembl=ENSMMUG00000016569|UniProtKB=F6VXE7	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00010	B cell activation	P00398	IP3R	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00005	Angiogenesis	P00223	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00024	Glycolysis	P00679	Aldolase	MACMU|Ensembl=ENSMMUG00000000983|UniProtKB=F6SYL4	Fructose-bisphosphate aldolase	ISS	4812352	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01331	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00896	Insulin IGF	HUMAN|HGNC=5464|UniProtKB=P05019	Insulin-like growth factor I	ISS			PTHR11454:SF4	INSULIN-LIKE GROWTH FACTOR I
P02738	De novo purine biosynthesis	P02892	5-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase	CHICK|Gene=ADSL|UniProtKB=P21265	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P04393	Ras Pathway	P04553	PAK	PANTR|Ensembl=ENSPTRG00000022187|UniProtKB=Q7YQL4	Serine/threonine-protein kinase PAK 3	ISS	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	LEIMA|EnsemblGenome=LmjF.04.1230|UniProtKB=Q9U1E8	Actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00019	Endothelin signaling pathway	P00586	Gq	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	MACMU|Ensembl=ENSMMUG00000001304|UniProtKB=F7BNR8	Receptor protein serine/threonine kinase	ISS	10683140	PubMed	PTHR23255:SF61	TGF-BETA RECEPTOR TYPE-1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	MONDO|Ensembl=ENSMODG00000017515|UniProtKB=F7F0J5	Uncharacterized protein	ISS	10082669	PubMed	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00009	Axon guidance mediated by netrin	P00364	cdc42	ASHGO|EnsemblGenome=AGOS_AGL093W|UniProtKB=Q9HF56	Cell division control protein 42	ISS	4757952	gi	PTHR24072:SF192	CDC42 HOMOLOG
P00012	Cadherin signaling pathway	P00475	Frizzled	ANOGA|EnsemblGenome=AGAP010442|UniProtKB=Q7QDV6	AGAP010442-PA	ISS	8717036	PubMed	PTHR11309:SF90	FRIZZLED-8
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00008	Axon guidance mediated by Slit/Robo	P00355	Rho	SCLS1|EnsemblGenome=SS1G_03867|UniProtKB=A7EEX6	RhoA protein	ISS	11973360	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00036	Interleukin signaling pathway	P00987	SRF	MOUSE|MGI=MGI=106658|UniProtKB=Q9JM73	Serum response factor	ISS	8660892	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00010	B cell activation	P00398	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00011	Blood coagulation	P00411	PAI-1	MOUSE|MGI=MGI=97608|UniProtKB=P22777	Plasminogen activator inhibitor 1	ISS	6981332	gi	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00059	p53 pathway	G04694	p110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01437	TCF	HUMAN|HGNC=11641|UniProtKB=Q9NQB0	Transcription factor 7-like 2	IDA	11266476	PubMed	PTHR10373:SF32	TRANSCRIPTION FACTOR 7-LIKE 2
P00010	B cell activation	P00391	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	IDA	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CHICK|Ensembl=ENSGALG00000019382|UniProtKB=E1BWK1	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00021	FGF signaling pathway	P00625	MKK3,6	ORNAN|Ensembl=ENSOANG00000007732|UniProtKB=F6PXH5	Uncharacterized protein (Fragment)	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	YARLI|EnsemblGenome=YALI0_D08272g|UniProtKB=Q9UVF3	Actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02747	Histidine biosynthesis	P02991	Histidinephosphate aminotransferase	BACSU|EnsemblGenome=BSU22620|UniProtKB=P17731	Histidinol-phosphate aminotransferase	ISS			PTHR43643:SF3	SUBFAMILY NOT NAMED
P02742	Tetrahydrofolate biosynthesis	P02944	Phosphoribosylglycinamide formyltransferase	METAC|EnsemblGenome=MA_0316|UniProtKB=Q8TTV9	Phosphoribosylglycinamide formyltransferase	ISS			PTHR43369:SF2	PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE
P04398	p53 pathway feedback loops 2	P04658	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MONDO|Ensembl=ENSMODG00000001389|UniProtKB=F7BD45	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF657	MYOSIN-4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IC	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	RCA	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	RAT|RGD=1309237|UniProtKB=D3ZCM7	Protein Tle1	ISS	9783586	PubMed	PTHR10814:SF23	TRANSDUCIN-LIKE ENHANCER PROTEIN 1
P00034	Integrin signalling pathway	P00910	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	8235613	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	RAT|RGD=3784|UniProtKB=P61265	Syntaxin-1B	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONBE|Gene=37852|UniProtKB=A9V489	Predicted protein	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04558	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05917	Opioid proopiomelanocortin pathway	P06006	beta-Endorphin	DANRE|ZFIN=ZDB-GENE-041014-294|UniProtKB=Q5SPP4	Uncharacterized protein	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00019	Endothelin signaling pathway	P00587	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IC	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00629	PP2A	NEUCR|Gene=NCU09377|UniProtKB=V5IPN6	Protein phosphatase PP2A regulatory subunit B	IGI	9987122	PubMed	PTHR11871:SF0	PROTEIN PHOSPHATASE PP2A 55 KDA REGULATORY SUBUNIT
P04393	Ras Pathway	P04557	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IDA	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	RAT|RGD=735207|UniProtKB=P80202	Activin receptor type-1B	TAS	9395284	PubMed	PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01154	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	87226391	PubMed	PTHR24070:SF385	GTPASE HRAS
P06959	CCKR signaling map	P07067	AP2M1	HUMAN|HGNC=564|UniProtKB=Q96CW1	AP-2 complex subunit mu	RCA	21156802	PubMed	PTHR10529:SF236	AP-2 COMPLEX SUBUNIT MU
P02783	Tryptophan biosynthesis	P03206	Anthranilate synthase	SYNY3|EnsemblGenome=BAA18216|UniProtKB=P74130	Anthranilate synthase component I-like protein	ISS			PTHR11236:SF23	SUBFAMILY NOT NAMED
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01131	MKP5	PANTR|Ensembl=ENSPTRG00000014254|UniProtKB=H2QLH7	Dual specificity phosphatase 18	ISS			PTHR10159:SF313	DUAL SPECIFICITY PROTEIN PHOSPHATASE 18
P00012	Cadherin signaling pathway	P00474	Wnt	PANTR|Ensembl=ENSPTRG00000019627|UniProtKB=H2QVA4	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P00012	Cadherin signaling pathway	P00468	Src	CHICK|Ensembl=ENSGALG00000003855|UniProtKB=P00523	Proto-oncogene tyrosine-protein kinase Src	ISS	8054685	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02741	Flavin biosynthesis	P02936	FAD synthetase	NEUCR|EnsemblGenome=EFNCRG00000003534|UniProtKB=Q6M923	Riboflavin kinase	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P00053	T cell activation	P01336	Jnk	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00036	Interleukin signaling pathway	P00966	mTOR	MONDO|Ensembl=ENSMODG00000011138|UniProtKB=F7BA89	Uncharacterized protein	ISS	7518356	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02723	Adenine and hypoxanthine salvage pathway	P02804	Hypoxanthine phosphoribosyl transferase	LEIMA|EnsemblGenome=LmjF.21.0845|UniProtKB=Q4QCC3	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	TAS	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00034	Integrin signalling pathway	P00951	Jnk	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00029	Huntington disease	P00776	c-Jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00025	Hedgehog signaling pathway	P00682	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04570	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00629	PP2A	PANTR|Ensembl=ENSPTRG00000003853|UniProtKB=H2Q411	Protein phosphatase 2, regulatory subunit B', beta	ISS	11531413	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01087	CAT	CANLF|Ensembl=ENSCAFG00000006672|UniProtKB=F1PR75	Uncharacterized protein	ISS	92155737	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00053	T cell activation	P01319	PAK	MACMU|Ensembl=ENSMMUG00000001387|UniProtKB=F7D0B4	Uncharacterized protein	ISS	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00018	EGF receptor signaling pathway	P00551	Akt	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	IGI	12719720	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	DANRE|ZFIN=ZDB-GENE-030131-8013|UniProtKB=F1QBT6	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00005	Angiogenesis	P00223	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00385	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000012820|UniProtKB=F1MDL3	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	10669416	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	RAT|RGD=2156|UniProtKB=P29066	Beta-arrestin-1	ISS	9388255	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00012	Cadherin signaling pathway	P00470	F-actin	RAT|RGD=2025|UniProtKB=P68136	Actin, alpha skeletal muscle	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	NEUCR|EnsemblGenome=EFNCRG00000004240|UniProtKB=Q01386	cAMP-dependent protein kinase regulatory subunit	IC	176892	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	CAEEL|WormBase=WBGene00016729|UniProtKB=P91167	Probable actin-related protein 2/3 complex subunit 5	ISS			PTHR12644:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00398	IP3R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	RAT|RGD=2520|UniProtKB=P61169	D(2) dopamine receptor	ISS	2039532	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00010	B cell activation	P00383	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	IDA	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00054	Toll receptor signaling pathway	P01345	IKKalpha	PANTR|Ensembl=ENSPTRG00000033948|UniProtKB=H2RBD4	Conserved helix-loop-helix ubiquitous kinase	ISS	9346484	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P06959	CCKR signaling map	P07090	MAPK8-10	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	RCA		PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000013587|UniProtKB=F7AZ16	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF33	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-3
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CHICK|Gene=CHRM4|UniProtKB=P17200	Muscarinic acetylcholine receptor M4	IDA	10069496	PubMed	PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00054	Toll receptor signaling pathway	G01550	Gene trancription	MOUSE|MGI=MGI=107657|UniProtKB=P01575	Interferon beta	ISS			PTHR11691:SF43	INTERFERON BETA
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	PANTR|Ensembl=ENSPTRG00000007084|UniProtKB=H2Q9G5	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00052	TGF-beta signaling pathway	P01284	JNK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	TAS	11007936	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00644	p38	DROME|FlyBase=FBgn0015765|UniProtKB=O62618	Mitogen-activated protein kinase 14A	IGI	10514528	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P02746	Heme biosynthesis	P02975	Uroporphyrinogen decarboxylase	BACSU|EnsemblGenome=BSU10120|UniProtKB=P32395	Uroporphyrinogen decarboxylase	ISS			PTHR21091:SF2	UROPORPHYRINOGEN DECARBOXYLASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00560	Raf-1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	PANTR|Ensembl=ENSPTRG00000019161|UniProtKB=H2QUJ4	Uncharacterized protein	ISS	89298382	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00019	Endothelin signaling pathway	P00589	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	IGI	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00996	STAT	CHICK|Ensembl=ENSGALG00000003282|UniProtKB=O93378	Signal transducer and activator of transcription	IC	20119183	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P05913	Enkephalin release	G06046	preproenkephalin mRNA	DANRE|ZFIN=ZDB-GENE-030729-31|UniProtKB=A8E7S2	Uncharacterized protein	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P06959	CCKR signaling map	P07059	BCL2	HUMAN|HGNC=990|UniProtKB=P10415	Apoptosis regulator Bcl-2	RCA	10611223	PubMed	PTHR11256:SF11	APOPTOSIS REGULATOR BCL-2
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000024633|UniProtKB=F1MBU9	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	TAS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01336	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IGI	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00810	GAPDH	CAEBR|Gene=CBG00820|UniProtKB=A8WNX0	Glyceraldehyde-3-phosphate dehydrogenase	ISS			PTHR10836:SF65	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE 1-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05966	EPB41	HUMAN|HGNC=3380|UniProtKB=Q9Y2J2	Band 4.1-like protein 3	IPI	12181426	PubMed	PTHR23280:SF20	BAND 4.1-LIKE PROTEIN 3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CIOIN|Ensembl=ENSCING00000000848|UniProtKB=F6SCP4	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00976	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IPI	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00030	Hypoxia response via HIF activation	P00824	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	TAS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P06664	Gonadotropin-releasing hormone receptor pathway	P06773	gnai/o	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	RCA	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00022	General transcription by RNA polymerase I	P00651	TAF-IA	MOUSE|MGI=MGI=1926879|UniProtKB=Q9EQH4	Transcription initiation factor TFIID subunit 8	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P05915	Opioid proenkephalin pathway	P05991	Enkephalin	PANTR|Ensembl=ENSPTRG00000013172|UniProtKB=H2QJT9	Uncharacterized protein	ISS	131330	OMIM	PTHR11438:SF4	PROENKEPHALIN-B
P00053	T cell activation	P01332	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00774	Dynein complex	HUMAN|HGNC=18744|UniProtKB=Q9GZS0	Dynein intermediate chain 2, axonemal	IPI	9454836	PubMed	PTHR12442:SF7	DYNEIN INTERMEDIATE CHAIN 2, AXONEMAL
P00012	Cadherin signaling pathway	P00467	alpha-catenin	HUMAN|HGNC=2510|UniProtKB=P26232	Catenin alpha-2	IDA	1638632	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P04393	Ras Pathway	P04558	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IGI	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00381	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00005	Angiogenesis	P00223	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01149	MNK1/2	RAT|RGD=1559603|UniProtKB=Q4G050	MAP kinase-interacting serine/threonine-protein kinase 1	ISS	97299868	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06804	Id2	MOUSE|MGI=MGI=96397|UniProtKB=P41136	DNA-binding protein inhibitor ID-2	RCA			PTHR11723:SF5	DNA-BINDING PROTEIN INHIBITOR ID-2-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	9860142	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00018	EGF receptor signaling pathway	P00549	EGF	HORSE|Ensembl=ENSECAG00000010741|UniProtKB=F7B762	Uncharacterized protein	RCA			PTHR44717:SF1	PRO-EPIDERMAL GROWTH FACTOR
P00052	TGF-beta signaling pathway	P01286	TGFbeta	RAT|RGD=2673|UniProtKB=Q9Z217	Growth/differentiation factor 11 (Fragment)	ISS	9759503	PubMed	PTHR11848:SF166	GROWTH/DIFFERENTIATION FACTOR 11
P04393	Ras Pathway	P04569	Cdc42	ASHGO|EnsemblGenome=AGOS_AGL093W|UniProtKB=Q9HF56	Cell division control protein 42	ISS	4757952	gi	PTHR24072:SF192	CDC42 HOMOLOG
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	RAT|RGD=1309504|UniProtKB=D3ZRN3	Protein Actbl2	ISS	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00049	Parkinson disease	P01208	Hsp70	DROME|FlyBase=FBgn0001216|UniProtKB=P29843	Heat shock 70 kDa protein cognate 1	IDA	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P02741	Flavin biosynthesis	P02936	FAD synthetase	ARATH|TAIR=AT5G03430|UniProtKB=Q9LZE4	Phosphoadenosine phosphosulfate (PAPS) reductase family protein	RCA			PTHR23293:SF9	FAD SYNTHASE
P00049	Parkinson disease	P01241	TH	RAT|RGD=3853|UniProtKB=P04177	Tyrosine 3-monooxygenase	TAS	12814656	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P02784	Tyrosine biosynthesis	P03213	Aromatic amino acid aminotransferase	MACMU|Ensembl=ENSMMUG00000002018|UniProtKB=F6TMN5	Tyrosine aminotransferase	ISS			PTHR11751:SF368	TYROSINE AMINOTRANSFERASE
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	BOVIN|Ensembl=ENSBTAG00000019210|UniProtKB=F1MJV4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00057	Wnt signaling pathway	P01448	CBP	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00006	Apoptosis signaling pathway	P00310	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00379	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00056	VEGF signaling pathway	P01407	Erk	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	PANTR|Ensembl=ENSPTRG00000020485|UniProtKB=H2QWJ3	Antizyme inhibitor 1	ISS			PTHR11482:SF7	ANTIZYME INHIBITOR 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	DANRE|ZFIN=ZDB-GENE-040801-121|UniProtKB=Q6DEH3	Calcium/calmodulin-dependent protein kinase type II delta 1 chain	ISS	12888804	PubMed	PTHR43940:SF4	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT DELTA
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P06217	Toll pathway-drosophila	P06340	SPE	DROME|FlyBase=FBgn0039102|UniProtKB=Q9VCJ8	GH28857p	IDA	12032070	PubMed	PTHR24260:SF3	GH28857P-RELATED
P00020	FAS signaling pathway	P00615	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00205	GAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	ISS	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	PANTR|Ensembl=ENSPTRG00000013022|UniProtKB=H2QJL0	Uncharacterized protein	ISS	8143856	PubMed	PTHR24247:SF31	5-HYDROXYTRYPTAMINE RECEPTOR 2B
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	TAKRU|Ensembl=ENSTRUG00000016241|UniProtKB=H2UX35	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF305	PROTEIN KINASE C
P00010	B cell activation	P00384	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	IDA	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00036	Interleukin signaling pathway	P00983	Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	IC	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	3045562	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IGI	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00057	Wnt signaling pathway	P01446	Calcineurin	DROME|FlyBase=FBgn0010015|UniProtKB=P48456	Serine/threonine-protein phosphatase 2B catalytic subunit 1	IDA	12015605	PubMed	PTHR11668:SF118	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01190	PDK1 ACT	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	12855688	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Ensembl=ENSGALG00000014620|UniProtKB=F1N8P3	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01428	Frizzled	CHICK|Ensembl=ENSGALG00000017242|UniProtKB=Q9IA05	Frizzled-4	IDA	8717036	PubMed	PTHR11309:SF23	FRIZZLED-4
P00057	Wnt signaling pathway	P01461	FrzB	XENTR|Xenbase=XB-GENE-481353|UniProtKB=F6RNC2	Uncharacterized protein	ISS	9118218	PubMed	PTHR11309:SF96	FRIZZLED-RELATED PROTEIN
P00046	Oxidative stress response	P01121	MKK3/6	MOUSE|MGI=MGI=1346868|UniProtKB=O09110	Dual specificity mitogen-activated protein kinase kinase 3	TAS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00057	Wnt signaling pathway	P01454	betaTrCP	MACMU|Ensembl=ENSMMUG00000016008|UniProtKB=F7FVG8	Uncharacterized protein	ISS	12628165	PubMed	PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	DANRE|ZFIN=ZDB-GENE-000330-9|UniProtKB=Q90ZE4	Presenilin-2	IDA	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02721	ATP synthesis	P02798	Cyt C	CANLF|Ensembl=ENSCAFG00000002856|UniProtKB=P00011	Cytochrome c	ISS	4347193	PubMed	PTHR11961:SF15	CYTOCHROME C
P00010	B cell activation	P00402	Jnk	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04570	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MACMU|Ensembl=ENSMMUG00000000893|UniProtKB=F6T7D0	Histone acetyltransferase p300	ISS	10823891	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g167737|UniProtKB=A7S8I3	Predicted protein	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	IC	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P06211	BMP/activin signaling pathway-drosophila	P06251	BMP/activin orthologous ligand	DROME|FlyBase=FBgn0024913|UniProtKB=O61643	Inhibin beta chain	RCA	9618266	PubMed	PTHR11848:SF133	INHIBIN BETA A CHAIN
P00021	FGF signaling pathway	P00629	PP2A	MACMU|Ensembl=ENSMMUG00000020819|UniProtKB=F7HSM1	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00543	ERK1-2	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00046	Oxidative stress response	P01126	ATF2	HUMAN|HGNC=784|UniProtKB=P15336	Cyclic AMP-dependent transcription factor ATF-2	TAS	7875593	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P02759	Pyridoxal-5-phosphate biosynthesis	P03058	Phosphohydroxythreonine aminotransferase	DANRE|ZFIN=ZDB-GENE-030131-5723|UniProtKB=Q803I7	Phosphoserine aminotransferase	ISS			PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P00021	FGF signaling pathway	P00638	PLCgamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00060	Ubiquitin proteasome pathway	P01491	E2	PANTR|Ensembl=ENSPTRG00000017240|UniProtKB=H2R5C5	Ubiquitin-conjugating enzyme E2B (RAD6 homolog)	ISS			PTHR43898:SF6	UBIQUITIN-CONJUGATING ENZYME E2 B
P00053	T cell activation	P01332	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P06959	CCKR signaling map	P07156	JAK2	HUMAN|HGNC=6192|UniProtKB=O60674	Tyrosine-protein kinase JAK2	RCA	15640156	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00034	Integrin signalling pathway	P00944	Actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00029	Huntington disease	P00807	Actin	SCHMA|EnsemblGenome=Smp_046600|UniProtKB=G4VLW2	Putative actin-1	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	YEAST|SGD=S000005738|UniProtKB=P18851	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04547	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00165	E-cadherin N-terminal fragment	MOUSE|MGI=MGI=88356|UniProtKB=P10287	Cadherin-3	TAS	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00053	T cell activation	P01311	Raf	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	TAS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00981	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	TAS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00036	Interleukin signaling pathway	P00970	Interleukin	PANTR|Ensembl=ENSPTRG00000004284|UniProtKB=H2Q4S4	Uncharacterized protein	ISS	11331040	PubMed	PTHR45200:SF1	INTERLEUKIN-18
P00005	Angiogenesis	P00233	CSL	MACMU|Ensembl=ENSMMUG00000015828|UniProtKB=F7CE90	Recombining binding protein suppressor of hairless isoform 4	ISS	12145413	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00047	PDGF signaling pathway	P01160	IP3 receptor	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	RAT|RGD=1598310|UniProtKB=Q4KLN6	Ribonucleoside-diphosphate reductase subunit M2	ISS			PTHR23409:SF20	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00053	T cell activation	P01332	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	BOVIN|Ensembl=ENSBTAG00000000469|UniProtKB=P67774	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	RAT|RGD=3187|UniProtKB=Q07008	Neurogenic locus notch homolog protein 1	IDA	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00057	Wnt signaling pathway	P01448	CBP	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00049	Parkinson disease	P01208	Hsp70	MOUSE|MGI=MGI=96243|UniProtKB=P17156	Heat shock-related 70 kDa protein 2	IDA	12150907	PubMed	PTHR19375:SF216	HEAT SHOCK-RELATED 70 KDA PROTEIN 2
P00019	Endothelin signaling pathway	P00572	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05913	Enkephalin release	P05977	G-Protein (s)	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00053	T cell activation	P01332	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00629	PP2A	TAKRU|Ensembl=ENSTRUG00000008018|UniProtKB=H2T5N4	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00056	VEGF signaling pathway	P01407	Erk	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00051	TCA cycle	P01274	Succinyl CoA Synthetase	MACMU|Ensembl=ENSMMUG00000000908|UniProtKB=F6RE42	Uncharacterized protein	ISS	97407896	PubMed	PTHR11117:SF2	SUCCINYL-COA LIGASE  ADP/GDP-FORMING  SUBUNIT ALPHA, MITOCHONDRIAL
P00049	Parkinson disease	P01234	GRK	MOUSE|MGI=MGI=87940|UniProtKB=Q99MK8	Beta-adrenergic receptor kinase 1	IDA	10085131	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00081	Pro-BACE-1	BOVIN|Ensembl=ENSBTAG00000019365|UniProtKB=Q2HJ40	Beta-secretase 1	ISS	10531052	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00034	Integrin signalling pathway	P00907	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=5293|UniProtKB=P28223	5-hydroxytryptamine receptor 2A	IDA			PTHR24247:SF30	5-HYDROXYTRYPTAMINE RECEPTOR 2A
P00060	Ubiquitin proteasome pathway	P01491	E2	ARATH|TAIR=AT2G16740|UniProtKB=Q9SLE4	Ubiquitin-conjugating enzyme E2 29	ISS			PTHR24068:SF47	SUMO-CONJUGATING ENZYME UBC9-RELATED
P00020	FAS signaling pathway	P00615	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05734	Synaptic vesicle trafficking	P05776	RIM1alpha/2alpha	CANLF|Ensembl=ENSCAFG00000002640|UniProtKB=F1PM67	Uncharacterized protein	ISS	11343654	PubMed	PTHR12157:SF19	REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN 1
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	BOVIN|Ensembl=ENSBTAG00000001153|UniProtKB=G5E510	Uncharacterized protein	ISS	9783586	PubMed	PTHR10814:SF4	AMINO-TERMINAL ENHANCER OF SPLIT-RELATED
P00048	PI3 kinase pathway	P01199	Galpha	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	RAT|RGD=3380|UniProtKB=P63331	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	MOUSE|MGI=MGI=95818|UniProtKB=Q61626	Glutamate receptor ionotropic, kainate 5	ISS	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	MACMU|Ensembl=ENSMMUG00000020790|UniProtKB=F7H9Z9	Interleukin-11 receptor subunit alpha isoform 1	ISS	12569176	PubMed	PTHR23036:SF29	INTERLEUKIN-11 RECEPTOR SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000009766|UniProtKB=F6TFL4	Uncharacterized protein	ISS	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00717	Phosphorylase b	CANLF|Ensembl=ENSCAFG00000014281|UniProtKB=F1P832	Alpha-1,4 glucan phosphorylase	ISS	4318782	PubMed	PTHR11468:SF13	GLYCOGEN PHOSPHORYLASE, MUSCLE FORM
P00057	Wnt signaling pathway	P01444	Wnt	MONDO|Ensembl=ENSMODG00000001196|UniProtKB=F7GH85	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000013587|UniProtKB=F7AZ16	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF33	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-3
P00021	FGF signaling pathway	P00628	JNK1-3	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PLAF7|EnsemblGenome=PF14_0124|UniProtKB=Q8ILW9	Actin-2	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00020	FAS signaling pathway	P00615	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00938	Cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00015	Circadian clock system	P00502	Casein kinase I	RAT|RGD=62045|UniProtKB=Q99PS2	Casein kinase1 epsilon-2	ISS	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P04396	Vitamin D metabolism and pathway	G04688	24-Hydroxylase	CHICK|Ensembl=ENSGALG00000012070|UniProtKB=F1NUL6	Uncharacterized protein	IDA	11686044	PubMed	PTHR24291:SF5	1,25-DIHYDROXYVITAMIN D 3  24-HYDROXYLASE, MITOCHONDRIAL
P00005	Angiogenesis	P00211	GSK3beta	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04393	Ras Pathway	P04567	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01448	CBP	ARATH|TAIR=AT3G12980|UniProtKB=Q9LE42	Histone acetyltransferase HAC5	IDA	8413673	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00003	Alzheimer disease-amyloid secretase pathway	P00092	TACE	HUMAN|HGNC=195|UniProtKB=P78536	Disintegrin and metalloproteinase domain-containing protein 17	IDA	9774383	PubMed	PTHR11905:SF171	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00057	Wnt signaling pathway	P01471	alpha-catenin	CAEEL|WormBase=WBGene00000832|UniProtKB=H2L011	Alpha-CaTuliN (Catenin/vinculin related)	ISS	9362521	PubMed	PTHR18914:SF8	ALPHA-CATULIN
P02761	Pantothenate biosynthesis	P03067	3-methyl-2-oxobutanoate hydroxymethyltransferase	YEAST|SGD=S000000380|UniProtKB=P38122	3-methyl-2-oxobutanoate hydroxymethyltransferase	ISS			PTHR20881:SF0	3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	RAT|RGD=2521|UniProtKB=P19020	D(3) dopamine receptor	RCA	11248120	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00045	Notch signaling pathway	P01113	Pen-2	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	ISS	12846562	PubMed	PTHR10202:SF13	PRESENILIN-2
P00030	Hypoxia response via HIF activation	P00823	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	ISS	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00004	Alzheimer disease-presenilin pathway	P00141	Membrane metalloprotease	RAT|RGD=620202|UniProtKB=Q99PW6	Matrix metalloproteinase-24	RCA			PTHR10201:SF138	MATRIX METALLOPROTEINASE-24
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00047	PDGF signaling pathway	P01154	Ras	XENTR|Xenbase=XB-GENE-494548|UniProtKB=F7EC26	Uncharacterized protein	ISS	10825661	PubMed	PTHR24070:SF186	GTPASE KRAS
P00006	Apoptosis signaling pathway	P00291	MEKK1	BOVIN|Ensembl=ENSBTAG00000013790|UniProtKB=E1B847	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00034	Integrin signalling pathway	P00917	ELMO	MONDO|Ensembl=ENSMODG00000013914|UniProtKB=F6TR56	Uncharacterized protein	ISS	12879077	PubMed	PTHR12771:SF8	ENGULFMENT AND CELL MOTILITY PROTEIN 2
P02738	De novo purine biosynthesis	P02909	GDP reductase	SYNY3|Gene=BAA18852|UniProtKB=P74732	Ribonucleoside-diphosphate reductase subunit beta	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	ARATH|TAIR=AT1G67890|UniProtKB=F4HVH9	PAS domain-containing protein tyrosine kinase	ISS			PTHR44676:SF2	PAS DOMAIN-CONTAINING PROTEIN TYROSINE KINASE-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MACMU|Ensembl=ENSMMUG00000000163|UniProtKB=F7HLV0	Uncharacterized protein	ISS	15155845	PubMed	PTHR18945:SF82	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-6
P00014	Cholesterol biosynthesis	P00493	Geranyl trans-transferase	ORYSJ|EnsemblGenome=OS01G0703400|UniProtKB=O04882	Farnesyl diphosphate synthase	ISS	O64905	SPACC	PTHR11525:SF0	FARNESYL PYROPHOSPHATE SYNTHASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00019	Endothelin signaling pathway	P00566	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	97102671	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00047	PDGF signaling pathway	P01157	MAPKAPK2	MACMU|Ensembl=ENSMMUG00000023567|UniProtKB=F7HHY8	Uncharacterized protein	ISS	10779545	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00037	Ionotropic glutamate receptor pathway	P01012	PICK	PANTR|Ensembl=ENSPTRG00000014359|UniProtKB=H2QLN1	Protein interacting with PRKCA 1	ISS	12941441	PubMed	PTHR12141:SF1	PRKCA-BINDING PROTEIN
P00053	T cell activation	P01324	rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12676940	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	HUMAN|HGNC=3373|UniProtKB=Q09472	Histone acetyltransferase p300	IDA			PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000008826|UniProtKB=F6XUU0	Uncharacterized protein	ISS			PTHR11937:SF240	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	12972619	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	TAS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04558	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00010	B cell activation	P00381	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000001384|UniProtKB=F7GL73	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00045	Notch signaling pathway	P01110	Presenilin	CHICK|Ensembl=ENSGALG00000009320|UniProtKB=Q4JIM4	Presenilin-1	ISS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00025	Hedgehog signaling pathway	P00693	Ubiquitin ligase	MOUSE|MGI=MGI=1918040|UniProtKB=Q80TP3	E3 ubiquitin-protein ligase UBR5	ISS			PTHR11254:SF402	E3 UBIQUITIN-PROTEIN LIGASE UBR5
P00047	PDGF signaling pathway	P01170	PDGF	DANRE|ZFIN=ZDB-GENE-030918-2|UniProtKB=A5PMP7	Uncharacterized protein	ISS			PTHR11633:SF3	PLATELET-DERIVED GROWTH FACTOR SUBUNIT A
P00057	Wnt signaling pathway	P01443	Phospholipase C	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00012	Cadherin signaling pathway	P00470	F-actin	DROME|FlyBase=FBgn0000045|UniProtKB=P02574	Actin, larval muscle	IC	11889126	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P04395	Vasopressin synthesis	P04599	Amidating Enzyme	DROME|FlyBase=FBgn0283509|UniProtKB=O01404	Peptidylglycine alpha-hydroxylating monooxygenase	IC	3153462	PubMed	PTHR10680:SF14	PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00048	PI3 kinase pathway	P01188	Gbetagamma	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00012	Cadherin signaling pathway	P00470	F-actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	IC	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00057	Wnt signaling pathway	P01451	Galpha	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IDA	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05731	GABA-B receptor II signaling	P05754	Ggamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00057	Wnt signaling pathway	P01455	Smad4	CHICK|Ensembl=ENSGALG00000009977|UniProtKB=Q56IA0	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P00046	Oxidative stress response	P01132	c-jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02772	Pyruvate metabolism	P03137	Citrate Lyase	MYCTU|EnsemblGenome=Rv3075c|UniProtKB=I6YF40	Conserved protein	ISS			PTHR32308:SF0	CITRATE LYASE SUBUNIT BETA
P00030	Hypoxia response via HIF activation	P00825	Thioredoxin	CHICK|Ensembl=ENSGALG00000015704|UniProtKB=P08629	Thioredoxin	ISS	12115731	PubMed	PTHR10438:SF18	THIOREDOXIN
P00048	PI3 kinase pathway	P01188	Gbetagamma	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	BOVIN|Ensembl=ENSBTAG00000015278|UniProtKB=Q5E963	Actin-related protein 2/3 complex subunit 5-like protein	ISS	12473693	PubMed	PTHR12644:SF2	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5-LIKE PROTEIN
P04393	Ras Pathway	P04558	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	12810719	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=2136752|UniProtKB=Q91Y03	MCG141291	IDA	8120095	PubMed	PTHR24028:SF61	PROTOCADHERIN BETA-13
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CANLF|Ensembl=ENSCAFG00000000185|UniProtKB=E2R4Q2	Uncharacterized protein	ISS	10321247	PubMed	PTHR19957:SF90	SYNTAXIN-7
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IDA	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	HUMAN|HGNC=1951|UniProtKB=P08172	Muscarinic acetylcholine receptor M2	ISS	91373358	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00021	FGF signaling pathway	P00623	FGF	RAT|RGD=620165|UniProtKB=Q8R5L7	Fibroblast growth factor 14	ISS			PTHR11486:SF18	FIBROBLAST GROWTH FACTOR 14
P00049	Parkinson disease	P01207	PLD2	MOUSE|MGI=MGI=892877|UniProtKB=P97813	Phospholipase D2	IDA	12615079	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	3755548	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	CAEBR|Gene=CBG15746|UniProtKB=A8XMP5	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00006	Apoptosis signaling pathway	P00260	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00807	Actin	ORYSJ|Gene=Os01g0866100|UniProtKB=P0C540	Actin-7	IDA	10974003	PubMed	PTHR11937:SF205	SUBFAMILY NOT NAMED
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=109356|UniProtKB=O09044	Synaptosomal-associated protein 23	IC	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00056	VEGF signaling pathway	P01409	cPLA2	BOVIN|Ensembl=ENSBTAG00000013298|UniProtKB=A4IFJ5	Cytosolic phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P02771	Pyrimidine Metabolism	P03124	Methylmalonate Semialdehyde Dehydrogenase	MYCTU|EnsemblGenome=LH57_04085|UniProtKB=O53816	Methylmalonate-semialdehyde dehydrogenase	ISS	12218036	PubMed	PTHR43866:SF4	SUBFAMILY NOT NAMED
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04393	Ras Pathway	P04558	p38	DANRE|ZFIN=ZDB-GENE-990415-257|UniProtKB=O42376	Mitogen-activated protein kinase 12	ISS	10851062	PubMed	PTHR24055:SF339	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00005	Angiogenesis	P00256	PLC-gamma	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00059	p53 pathway	P01486	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	RAT|RGD=619965|UniProtKB=P26769	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	IC	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00046	Oxidative stress response	P01126	ATF2	CHICK|Ensembl=ENSGALG00000009287|UniProtKB=O93602	Cyclic AMP-dependent transcription factor ATF-2	TAS	10207617	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P02741	Flavin biosynthesis	P02936	FAD synthetase	GLOVI|Gene=BAC88158|UniProtKB=Q7NP41	Riboflavin biosynthesis protein	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P00048	PI3 kinase pathway	P01185	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00056	VEGF signaling pathway	P01413	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00204	PLD	PANTR|Ensembl=ENSPTRG00000008610|UniProtKB=H2QBY9	Uncharacterized protein	ISS	12615079	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04393	Ras Pathway	P04569	Cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00003	Alzheimer disease-amyloid secretase pathway	P00079	alpha7 nicotinic acetylcholine receptor	HUMAN|HGNC=1960|UniProtKB=P36544	Neuronal acetylcholine receptor subunit alpha-7	IDA	11404397	PubMed	PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P00029	Huntington disease	P00777	CBP	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00021	FGF signaling pathway	P00648	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00046	Oxidative stress response	P01124	Myc	PANTR|Gene=MYC|UniProtKB=P23583	Myc proto-oncogene protein	TAS	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	TAS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00034	Integrin signalling pathway	P00920	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00057	Wnt signaling pathway	P01440	Cadherin	DANRE|ZFIN=ZDB-GENE-980526-242|UniProtKB=F1REQ8	Uncharacterized protein	IDA	8120095	PubMed	PTHR24028:SF96	SUBFAMILY NOT NAMED
P02781	Threonine biosynthesis	P03190	Threonine synthase	RAT|RGD=1309144|UniProtKB=Q5M7T9	Threonine synthase-like 2	ISS			PTHR42690:SF1	THREONINE SYNTHASE-LIKE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	MONDO|Ensembl=ENSMODG00000007323|UniProtKB=F7EFD0	Uncharacterized protein	ISS	10476970	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00048	PI3 kinase pathway	P01182	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P06959	CCKR signaling map	P07103	PRKD1	HUMAN|HGNC=9407|UniProtKB=Q15139	Serine/threonine-protein kinase D1	RCA	21810446	PubMed	PTHR22968:SF9	SERINE/THREONINE-PROTEIN KINASE D1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P02754	Methylcitrate cycle	P03028	Aconitase	MACMU|Ensembl=ENSMMUG00000008196|UniProtKB=F7HA06	Aconitate hydratase	ISS			PTHR11670:SF32	CYTOPLASMIC ACONITATE HYDRATASE
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	TAKRU|Ensembl=ENSTRUG00000008723|UniProtKB=H2TB66	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF331	SUBFAMILY NOT NAMED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00007	Axon guidance mediated by semaphorins	P00330	CRAM	PANTR|Ensembl=ENSPTRG00000011741|UniProtKB=H2R8X1	Uncharacterized protein	ISS	10851247	PubMed	PTHR11647:SF58	DIHYDROPYRIMIDINASE-RELATED PROTEIN 5
P00011	Blood coagulation	P00434	FXIa	MACMU|Ensembl=ENSMMUG00000020064|UniProtKB=F7GHR4	Uncharacterized protein	ISS	14270123	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	HUMAN|HGNC=5967|UniProtKB=Q14626	Interleukin-11 receptor subunit alpha	IDA	12569176	PubMed	PTHR23036:SF29	INTERLEUKIN-11 RECEPTOR SUBUNIT ALPHA
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	10540223	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00057	Wnt signaling pathway	P01456	beta-arrestin	HUMAN|HGNC=712|UniProtKB=P32121	Beta-arrestin-2	IDA	11742073	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00047	PDGF signaling pathway	P01162	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00048	PI3 kinase pathway	P01177	P110ACT	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	RAT|RGD=620196|UniProtKB=P23097	Collagenase 3 (Fragment)	TAS	12834808	PubMed	PTHR10201:SF165	COLLAGENASE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	TAKRU|Ensembl=ENSTRUG00000016101|UniProtKB=H2UW32	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00060	Ubiquitin proteasome pathway	P01490	E3	CHICK|Ensembl=ENSGALG00000003566|UniProtKB=F1NJU6	Uncharacterized protein	ISS	11252892	PubMed	PTHR11254:SF300	E3 UBIQUITIN-PROTEIN LIGASE SMURF2
P05913	Enkephalin release	P05977	G-Protein (s)	MACMU|Ensembl=ENSMMUG00000014807|UniProtKB=F6W548	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Ensembl=ENSPTRG00000018449|UniProtKB=H2QTG5	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00034	Integrin signalling pathway	P00925	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00005	Angiogenesis	P00236	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	PANTR|Ensembl=ENSPTRG00000008771|UniProtKB=H2QCA0	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF484	MYOSIN-1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05916	Opioid prodynorphin pathway	P05999	provasopressin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00056	VEGF signaling pathway	P01414	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05918	p38 MAPK pathway	P06025	SRF	HUMAN|HGNC=11291|UniProtKB=P11831	Serum response factor	RCA	15170389	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	IC	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00050	Plasminogen activating cascade	P01255	Plasminogen	RAT|RGD=619893|UniProtKB=Q01177	Plasminogen	IDA	15928602	gi	PTHR24261:SF5	PLASMINOGEN
P00048	PI3 kinase pathway	P01199	Galpha	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04393	Ras Pathway	P04557	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	IDA	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05916	Opioid prodynorphin pathway	P06002	G-protein	CAEEL|WormBase=WBGene00001680|UniProtKB=Q20636	Guanine nucleotide-binding protein subunit beta-2	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00048	PI3 kinase pathway	P01192	p110	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04570	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00006	Apoptosis signaling pathway	P00321	HSP70	ORNAN|Ensembl=ENSOANG00000009457|UniProtKB=F6ZXI7	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF216	HEAT SHOCK-RELATED 70 KDA PROTEIN 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00749	RGS9	MOUSE|MGI=MGI=1338824|UniProtKB=O54828	Regulator of G-protein signaling 9	IDA	8756726	PubMed	PTHR10845:SF170	REGULATOR OF G-PROTEIN SIGNALING 9
P00057	Wnt signaling pathway	P01457	GBeta	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00006	Apoptosis signaling pathway	P00318	PKCs	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00049	Parkinson disease	P01242	Casein kinase I	DROME|FlyBase=FBgn0015024|UniProtKB=P54367	Casein kinase I isoform alpha	IDA	11955435	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00036	Interleukin signaling pathway	P00990	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01457	GBeta	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	PANTR|Ensembl=ENSPTRG00000022245|UniProtKB=H2QZ29	Uncharacterized protein	ISS	20112749	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00048	PI3 kinase pathway	P01199	Galpha	MACMU|Ensembl=ENSMMUG00000005819|UniProtKB=F6VKI4	Uncharacterized protein	ISS			PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=2443588|UniProtKB=Q5SW28	Phosphoinositide 3-kinase regulatory subunit 5	ISS			PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P02746	Heme biosynthesis	P02980	Coproporphyrinogen Oxidase (oxygen dependent)	ECOLI|EcoGene=EG12189|UniProtKB=P36553	Oxygen-dependent coproporphyrinogen-III oxidase	ISS			PTHR10755:SF0	OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT4G36450|UniProtKB=O23236	Mitogen-activated protein kinase 14	ISS	9836510	gi	PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00828	Galphai	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	RCA			PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	RAT|RGD=2732|UniProtKB=P22756	Glutamate receptor ionotropic, kainate 1	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00034	Integrin signalling pathway	P00941	Integrin alpha	HUMAN|HGNC=6143|UniProtKB=Q13683	Integrin alpha-7	IPI	3487386	PubMed	PTHR23220:SF90	INTEGRIN ALPHA-7
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	IDA	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	MOUSE|MGI=MGI=88256|UniProtKB=P11798	Calcium/calmodulin-dependent protein kinase type II subunit alpha	IDA	10092204	PubMed	PTHR43940:SF5	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA
P00005	Angiogenesis	P00254	GTPase	CAEBR|Gene=CBG13664|UniProtKB=A8XIF5	Protein CBR-RHO-1	ISS			PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CANLF|Ensembl=ENSCAFG00000013332|UniProtKB=F1PCQ4	Uncharacterized protein	ISS	9819389	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00012	Cadherin signaling pathway	P00474	Wnt	DROME|FlyBase=FBgn0010453|UniProtKB=P40589	Protein Wnt-4	ISS	8717036	PubMed	PTHR12027:SF102	PROTEIN WNT-4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00892	Grb2	DANRE|ZFIN=ZDB-GENE-040426-1975|UniProtKB=Q6PC73	Growth factor receptor-bound protein 2	ISS	http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd	Website	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00049	Parkinson disease	P01238	14-3-3	DANRE|ZFIN=ZDB-GENE-030131-6583|UniProtKB=Q5PRD0	14-3-3 protein beta/alpha-A	ISS	21864508	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TRYB2|Gene=Tb09.211.0620|UniProtKB=Q38E94	Actin A	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00025	Hedgehog signaling pathway	P00692	GSK3	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00053	T cell activation	P01315	Calcineurin	RAT|RGD=3383|UniProtKB=P20651	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	IGI	12015605	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IPI	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00023	General transcription regulation	P00658	TBP-associated factors	YEAST|SGD=S000003080|UniProtKB=P53040	Transcription initiation factor TFIID subunit 6	ISS			PTHR10221:SF9	TAF6-LIKE RNA POLYMERASE II P300/CBP-ASSOCIATED FACTOR-ASSOCIATED FACTOR 65 KDA SUBUNIT 6L
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IDA			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00321	HSP70	MACMU|Ensembl=ENSMMUG00000029822|UniProtKB=F7CZ86	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF210	HEAT SHOCK 70 KDA PROTEIN 1-LIKE
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	PANTR|Ensembl=ENSPTRG00000005858|UniProtKB=H2Q7J6	Uncharacterized protein	ISS	12181435	PubMed	PTHR24247:SF30	5-HYDROXYTRYPTAMINE RECEPTOR 2A
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000010195|UniProtKB=E1B7J3	Uncharacterized protein	ISS	10644715	PubMed	PTHR24356:SF175	SERINE/THREONINE-PROTEIN KINASE N3
P00011	Blood coagulation	P00451	Kininogen	PANTR|Ensembl=ENSPTRG00000015717|UniProtKB=H2QNX2	Uncharacterized protein	ISS	4504893	gi	PTHR13814:SF12	KININOGEN-1
P00004	Alzheimer disease-presenilin pathway	P00127	APP	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00029	Huntington disease	P00807	Actin	HUMAN|HGNC=145|UniProtKB=P63267	Actin, gamma-enteric smooth muscle	IDA	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00029	Huntington disease	P00790	beta-Tubulin	MOUSE|MGI=MGI=107814|UniProtKB=A2AQ07	Tubulin beta-1 chain	TAS	9454836	PubMed	PTHR11588:SF112	TUBULIN BETA-1 CHAIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	EMENI|EnsemblGenome=CADANIAG00006296|UniProtKB=Q5ASG1	Putative synaptobrevin homologue SNC1/2 (Eurofung)	ISS			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00054	Toll receptor signaling pathway	P01358	ERK1	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00640	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00383	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00059	p53 pathway	G04694	p110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06780	ActRII/IIB	MOUSE|MGI=MGI=102806|UniProtKB=P27038	Activin receptor type-2A	RCA	11252892	PubMed	PTHR23255:SF64	ACTIVIN RECEPTOR TYPE-2A
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00007	Axon guidance mediated by semaphorins	P00339	CRMP	HUMAN|HGNC=3014|UniProtKB=Q16555	Dihydropyrimidinase-related protein 2	IDA	7637782	PubMed	PTHR11647:SF56	DIHYDROPYRIMIDINASE-RELATED PROTEIN 2
P00021	FGF signaling pathway	P00624	14-3-3	RAT|RGD=61998|UniProtKB=P35213	14-3-3 protein beta/alpha	ISS	91108808	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00054	Toll receptor signaling pathway	P01375	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00049	Parkinson disease	P01212	p38 MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MONDO|Ensembl=ENSMODG00000009414|UniProtKB=F7C5D6	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF74	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00114	actin	STRPU|EnsemblGenome=SPU_012282|UniProtKB=W4Y969	Uncharacterized protein	IDA	10974003	PubMed	PTHR11937:SF369	ACTIN-42A
P00029	Huntington disease	P00788	Calpain	HUMAN|HGNC=1482|UniProtKB=O15484	Calpain-5	ISS	11675509	PubMed	PTHR10183:SF370	CALPAIN-5
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	DROME|FlyBase=FBgn0011582|UniProtKB=P41596	Dopamine receptor 1	IDA			PTHR43893:SF6	DOPAMINE RECEPTOR 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00095	Nicastrin	MACMU|Ensembl=ENSMMUG00000021856|UniProtKB=F7EHX8	Nicastrin	ISS	10993067	PubMed	PTHR21092:SF0	NICASTRIN
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01026	KA	ORNAN|Ensembl=ENSOANG00000010302|UniProtKB=F6TDQ6	Uncharacterized protein	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=13681|UniProtKB=Q96JQ0	Protocadherin-16	IDA	8120095	PubMed	PTHR43956:SF6	PROTOCADHERIN-16
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01471	alpha-catenin	DROME|Gene=Dmel_CG2987|UniProtKB=A0A0C4DHD7	Alpha-catenin related, isoform C	IDA	9362521	PubMed	PTHR18914:SF8	ALPHA-CATULIN
P00006	Apoptosis signaling pathway	P00302	ATF	HUMAN|HGNC=784|UniProtKB=P15336	Cyclic AMP-dependent transcription factor ATF-2	ISS	10487205	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00021	FGF signaling pathway	P00632	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IGI	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00015	Circadian clock system	G01501	cry	DANRE|ZFIN=ZDB-GENE-010426-8|UniProtKB=F1QHM9	Uncharacterized protein	ISS			PTHR11455:SF9	6-4 -PHOTOLYASE, ISOFORM A
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	IGI	9836510	gi	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00057	Wnt signaling pathway	P01432	Beta-Catenin	MACMU|Ensembl=ENSMMUG00000014627|UniProtKB=F7GNE4	Catenin beta-1	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MONDO|Ensembl=ENSMODG00000016595|UniProtKB=F6ZDB2	Uncharacterized protein	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P05913	Enkephalin release	P05972	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00540	MKK3,6	BOVIN|Ensembl=ENSBTAG00000010576|UniProtKB=A4IFH7	MAP2K3 protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00034	Integrin signalling pathway	P00942	Fyn	CHICK|Gene=FYN|UniProtKB=Q05876	Tyrosine-protein kinase Fyn	IPI	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P05913	Enkephalin release	P05977	G-Protein (s)	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DROME|FlyBase=FBgn0003093|UniProtKB=P13678	Protein kinase C	IC	3045562	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01219	SAPK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00024	Glycolysis	P00678	Enolase	MACMU|Ensembl=ENSMMUG00000022947|UniProtKB=F6U6Q6	Uncharacterized protein	ISS	89079778	PubMed	PTHR11902:SF12	ALPHA-ENOLASE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CANLF|Ensembl=ENSCAFG00000002617|UniProtKB=E2QUL1	Uncharacterized protein	ISS	11554549	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00018	EGF receptor signaling pathway	P00547	PP2A	MOUSE|MGI=MGI=2388480|UniProtKB=Q6PD28	Protein Ppp2r5b	ISS	10092233	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01437	TCF	DANRE|ZFIN=ZDB-GENE-980605-30|UniProtKB=Q9YHE8	Transcription factor 7-like 1-A	IDA	12356903	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00048	PI3 kinase pathway	P01179	PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000009626|UniProtKB=F6ZYQ0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	DANRE|ZFIN=ZDB-GENE-060824-1|UniProtKB=C3PTE8	Beta-arrestin 1	ISS	4757780	gi	PTHR11792:SF22	BETA-ARRESTIN-1
P00045	Notch signaling pathway	P01104	Serrate	CANLF|Ensembl=ENSCAFG00000005627|UniProtKB=E2QUR0	Delta-like protein	ISS	12826675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-040426-2427|UniProtKB=F1Q6C0	Uncharacterized protein (Fragment)	ISS	3037538	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01198	FOXO	PANTR|Ensembl=ENSPTRG00000018476|UniProtKB=H2R710	Forkhead box O3	ISS	15031210	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00029	Huntington disease	P00774	Dynein complex	MACMU|Ensembl=ENSMMUG00000004868|UniProtKB=F7AP66	Dynein light chain 4, axonemal	ISS	9454836	PubMed	PTHR11886:SF2	DYNEIN LIGHT CHAIN 4, AXONEMAL
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00053	T cell activation	P01332	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01408	Akt/PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01443	Phospholipase C	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05913	Enkephalin release	P05977	G-Protein (s)	BOVIN|Ensembl=ENSBTAG00000003762|UniProtKB=A5PJS1	GNB5 protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00059	p53 pathway	G04691	IGF-BP3	PANTR|Ensembl=ENSPTRG00000019166|UniProtKB=H2QUJ6	Uncharacterized protein	ISS			PTHR11551:SF3	INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 3
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00053	T cell activation	P01300	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05913	Enkephalin release	P05972	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00648	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00219	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00005	Angiogenesis	P00209	FAK	CHICK|Ensembl=ENSGALG00000016171|UniProtKB=Q00944	Focal adhesion kinase 1	ISS	12640026	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00006	Apoptosis signaling pathway	P00260	AKT	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IC	3045562	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00049	Parkinson disease	P01239	Cul-1	PANTR|Ensembl=ENSPTRG00000019836|UniProtKB=G2HEC7	Cullin 1	ISS	12628165	PubMed	PTHR11932:SF81	CULLIN-1
P00012	Cadherin signaling pathway	P00470	F-actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00009	Axon guidance mediated by netrin	P00364	cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00036	Interleukin signaling pathway	P00996	STAT	CANLF|Ensembl=ENSCAFG00000015509|UniProtKB=F1PNW8	Signal transducer and activator of transcription	ISS	8732682	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00056	VEGF signaling pathway	P01414	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00059	p53 pathway	P04619	HMG1	BOVIN|Ensembl=ENSBTAG00000018103|UniProtKB=P10103	High mobility group protein B1	ISS			PTHR13711:SF164	HIGH MOBILITY GROUP PROTEIN B1-RELATED
P06664	Gonadotropin-releasing hormone receptor pathway	G06680	c-fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	RCA	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00053	T cell activation	P01294	NFAT	RAT|RGD=1308692|UniProtKB=A0A0G2JTY4	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 (Predicted), isoform CRA_b	ISS	9133421	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P02770	Pyridoxal phosphate salvage pathway	P03123	Pyridoxine-5-phosphate oxidase	HUMAN|HGNC=30260|UniProtKB=Q9NVS9	Pyridoxine-5'-phosphate oxidase	ISS	9601034	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	TAS	12855688	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	3136397	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00048	PI3 kinase pathway	P01188	Gbetagamma	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00018	EGF receptor signaling pathway	P00558	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	IDA	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00010	B cell activation	P00402	Jnk	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	IDA	3487386	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00021	FGF signaling pathway	P00648	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04397	p53 pathway by glucose deprivation	P04641	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00010	B cell activation	P00376	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00020	FAS signaling pathway	P00609	FAF1	CHICK|Ensembl=ENSGALG00000010536|UniProtKB=F1NLG1	Uncharacterized protein	ISS	8524870	PubMed	PTHR23322:SF52	FAS-ASSOCIATED FACTOR 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	TRYB2|Gene=Tb11.v4.0006|UniProtKB=Q382Q1	Ribonucleoside-diphosphate reductase small chain	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00060	Ubiquitin proteasome pathway	P01491	E2	ARATH|TAIR=AT2G02760|UniProtKB=P42745	Ubiquitin-conjugating enzyme E2 2	ISS			PTHR43898:SF5	UBIQUITIN-CONJUGATING ENZYME E2 1-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	CHICK|Ensembl=ENSGALG00000012291|UniProtKB=Q9PT88	RNA polymerase common subunit RPB6	ISS	6522685	gi	PTHR10773:SF12	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00029	Huntington disease	P00775	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	HUMAN|HGNC=1402|UniProtKB=Q08289	Voltage-dependent L-type calcium channel subunit beta-2	IC	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00108	ADAM10	MACMU|Ensembl=ENSMMUG00000017507|UniProtKB=F6V4A7	Uncharacterized protein	ISS	10097139	PubMed	PTHR11905:SF4	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 10
P02775	Salvage pyrimidine ribonucleotides	P03149	Cytidine kinase	ARATH|TAIR=AT3G27190|UniProtKB=Q9LK34	Uridine kinase-like protein 2, chloroplastic	ISS			PTHR10285:SF70	URIDINE-CYTIDINE KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	BOVIN|Ensembl=ENSBTAG00000018204|UniProtKB=Q9BE40	Myosin-1	ISS	89264452	PubMed	PTHR13140:SF484	MYOSIN-1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00054	Toll receptor signaling pathway	P01345	IKKalpha	BOVIN|Ensembl=ENSBTAG00000007591|UniProtKB=Q95KV1	Inhibitor of nuclear factor kappa-B kinase subunit alpha	ISS	12235208	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	IC	11956331	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	BOVIN|Ensembl=ENSBTAG00000018777|UniProtKB=E1BHU9	Uncharacterized protein	ISS	1409703	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00048	PI3 kinase pathway	P01182	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	IC	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00005	Angiogenesis	P00206	Wnt	TAKRU|Ensembl=ENSTRUG00000011562|UniProtKB=H2TX02	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000018372|UniProtKB=F7H1J2	Uncharacterized protein	ISS	11259498	PubMed	PTHR24229:SF1	KAPPA-TYPE OPIOID RECEPTOR
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00045	Notch signaling pathway	P01114	Ntm	MOUSE|MGI=MGI=99460|UniProtKB=Q61982	Neurogenic locus notch homolog protein 3	IC	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CHICK|Ensembl=ENSGALG00000014539|UniProtKB=F1N861	Uncharacterized protein	ISS	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00046	Oxidative stress response	P01133	Max	ORNAN|Ensembl=ENSOANG00000005841|UniProtKB=F7BWL6	Uncharacterized protein	ISS	11274345	PubMed	PTHR10328:SF3	PROTEIN MAX
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	IC	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	MACMU|Ensembl=ENSMMUG00000016428|UniProtKB=F7GU00	Metabotropic glutamate receptor 1 isoform alpha	ISS	12488551	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04398	p53 pathway feedback loops 2	P04651	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	P01456	beta-arrestin	MOUSE|MGI=MGI=99474|UniProtKB=Q91YI4	Beta-arrestin-2	IDA	9388255	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00011	Blood coagulation	P00434	FXIa	HUMAN|HGNC=3551|UniProtKB=P00740	Coagulation factor IX	ISS	14270123	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P00010	B cell activation	P00398	IP3R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00006	Apoptosis signaling pathway	P00318	PKCs	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IDA	2837282	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P02769	Purine metabolism	P03116	Xanthine Oxidase	PANTR|Ensembl=ENSPTRG00000011806|UniProtKB=H2QHQ2	Uncharacterized protein	ISS	12969896	PubMed	PTHR11908:SF80	XANTHINE DEHYDROGENASE/OXIDASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	RCA	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00048	PI3 kinase pathway	P01192	p110	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00932	FAK	XENTR|Xenbase=XB-GENE-952025|UniProtKB=F7CW18	Uncharacterized protein	ISS	12640026	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	PANTR|Ensembl=ENSPTRG00000003699|UniProtKB=H2Q3R5	Syntaxin 3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	SCLS1|EnsemblGenome=SS1G_03482|UniProtKB=A7EDU2	Guanine nucleotide-binding protein beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00053	T cell activation	P01307	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04666	cyclin A	HUMAN|HGNC=1577|UniProtKB=P78396	Cyclin-A1	RCA			PTHR10177:SF254	CYCLIN-A1
P00036	Interleukin signaling pathway	P00981	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	PANTR|Ensembl=ENSPTRG00000018684|UniProtKB=C7G3M7	Glutamate receptor, metabotropic 1	ISS	8314195	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00034	Integrin signalling pathway	P00927	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	RCA	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02751	Lysine biosynthesis	P03009	Aspartokinase	DEIRA|EnsemblGenome=DR_1365|UniProtKB=Q9RUL9	Aspartokinase	ISS			PTHR21499:SF3	ASPARTOKINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MACMU|Ensembl=ENSMMUG00000012054|UniProtKB=F6TII3	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00006	Apoptosis signaling pathway	P00318	PKCs	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	RCA	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00049	Parkinson disease	P01227	20S proteasome	CAEEL|WormBase=WBGene00003923|UniProtKB=Q27488	Proteasome subunit alpha type-2	TAS	12859888	PubMed	PTHR11599:SF16	PROTEASOME SUBUNIT ALPHA TYPE-2
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00054	Toll receptor signaling pathway	P01375	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=1306541|UniProtKB=D3ZVF3	Phosphoinositide-3-kinase, class 2, beta polypeptide (Predicted)	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P04398	p53 pathway feedback loops 2	P04657	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00060	Ubiquitin proteasome pathway	P01491	E2	MOUSE|MGI=MGI=102959|UniProtKB=Q9Z255	Ubiquitin-conjugating enzyme E2 A	ISS			PTHR43898:SF4	UBIQUITIN-CONJUGATING ENZYME E2 A
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00048	PI3 kinase pathway	P01182	Ras	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P02741	Flavin biosynthesis	P02936	FAD synthetase	DROME|FlyBase=FBgn0014930|UniProtKB=O76206	Putative riboflavin kinase	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P00006	Apoptosis signaling pathway	P00269	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	DROME|FlyBase=FBgn0283494|UniProtKB=Q9U915	Adenylate kinase	ISS			PTHR23359:SF117	ADENYLATE KINASE 2, MITOCHONDRIAL
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00759	PDEalphabeta	MONDO|Ensembl=ENSMODG00000005968|UniProtKB=F6W037	Phosphodiesterase	ISS			PTHR11347:SF73	ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT BETA
P00019	Endothelin signaling pathway	P00590	IP3 R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IGI	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04393	Ras Pathway	P04578	Rho	DANRE|ZFIN=ZDB-GENE-040426-2150|UniProtKB=Q6NUX8	Rho-related GTP-binding protein RhoA-A	ISS	12024019	PubMed	PTHR24072:SF260	RHO-RELATED GTP-BINDING PROTEIN RHOA-A-RELATED
P00053	T cell activation	P01316	MHC-antigen	PANTR|Ensembl=ENSPTRG00000007020|UniProtKB=P61770	Beta-2-microglobulin	ISS			PTHR19944:SF62	BETA-2-MICROGLOBULIN
P06664	Gonadotropin-releasing hormone receptor pathway	P06831	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	RCA	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	PANTR|Ensembl=ENSPTRG00000020739|UniProtKB=H2R6U6	Solute carrier family 1 (Neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	ISS	94365697	PubMed	PTHR11958:SF69	EXCITATORY AMINO ACID TRANSPORTER 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	DROME|FlyBase=FBgn0266137|UniProtKB=Q24563	Dopamine receptor 2	IDA	11248120	PubMed	PTHR24248:SF56	DOPAMINE RECEPTOR 2
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00056	VEGF signaling pathway	P01408	Akt/PKB	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00321	HSP70	XENTR|Xenbase=XB-GENE-485626|UniProtKB=A9JTJ5	Hsp70 protein	ISS	12150907	PubMed	PTHR19375:SF315	SUBFAMILY NOT NAMED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=88355|UniProtKB=P15116	Cadherin-2	IDA	13678586	PubMed	PTHR24027:SF79	CADHERIN-2
P00035	Interferon-gamma signaling pathway	P00961	STAT1	HUMAN|HGNC=11362|UniProtKB=P42224	Signal transducer and activator of transcription 1-alpha/beta	TAS	15825084	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00018	EGF receptor signaling pathway	P00548	RKIP	HUMAN|HGNC=28319|UniProtKB=Q96S96	Phosphatidylethanolamine-binding protein 4	ISS			PTHR11362:SF70	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4
P05731	GABA-B receptor II signaling	P05760	AC	BOVIN|Ensembl=ENSBTAG00000014600|UniProtKB=E1BQ12	Uncharacterized protein	ISS	12890691	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00972	MNK1/2	RAT|RGD=1305728|UniProtKB=Q5U2N4	MAP kinase-interacting serine/threonine-protein kinase 2	ISS	9155017	PubMed	PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P00048	PI3 kinase pathway	P01177	P110ACT	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00642	MEK1-2	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04393	Ras Pathway	P04572	JNK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CAEBR|Gene=CBG23091|UniProtKB=A8Y4Q9	Protein CBR-ACT-2	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05918	p38 MAPK pathway	P06025	SRF	RAT|RGD=1559787|UniProtKB=D3ZHH8	Protein Srf	ISS	15170389	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	IC	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01185	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00057	Wnt signaling pathway	P01443	Phospholipase C	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02738	De novo purine biosynthesis	P02891	GDP kinase	BOVIN|Ensembl=ENSBTAG00000008752|UniProtKB=E1BDQ6	Uncharacterized protein	ISS			PTHR11349:SF64	NUCLEOSIDE DIPHOSPHATE KINASE HOMOLOG 5
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	XENTR|Xenbase=XB-GENE-494200|UniProtKB=F7CS79	Uncharacterized protein	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00029	Huntington disease	P00778	NMDA receptor	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	IDA	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	ARATH|TAIR=AT4G01850|UniProtKB=P17562	S-adenosylmethionine synthase 2	ISS			PTHR11964:SF21	S-ADENOSYLMETHIONINE SYNTHASE 1-RELATED
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	RAT|RGD=2721|UniProtKB=P13221	Aspartate aminotransferase, cytoplasmic	ISS			PTHR11879:SF3	ASPARTATE AMINOTRANSFERASE, CYTOPLASMIC
P00034	Integrin signalling pathway	P00907	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04559	Rac	HUMAN|HGNC=9803|UniProtKB=P60763	Ras-related C3 botulinum toxin substrate 3	ISS	15470041	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	HUMAN|HGNC=143|UniProtKB=P68032	Actin, alpha cardiac muscle 1	IEP	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00805	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00402	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00053	T cell activation	P01334	WASP	HUMAN|HGNC=12731|UniProtKB=P42768	Wiskott-Aldrich syndrome protein	IGI	10544204	PubMed	PTHR23202:SF35	WISKOTT-ALDRICH SYNDROME PROTEIN
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00017	DNA replication	P00538	RNase H	PANTR|Ensembl=ENSPTRG00000011614|UniProtKB=H2QHD3	Ribonuclease H1	ISS	12473655	PubMed	PTHR10642:SF0	RIBONUCLEASE H1
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04547	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	87226391	PubMed	PTHR24070:SF385	GTPASE HRAS
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	DROME|FlyBase=FBgn0019985|UniProtKB=P91685	Metabotropic glutamate receptor	IDA	12351712	PubMed	PTHR24060:SF137	METABOTROPIC GLUTAMATE RECEPTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MACMU|Ensembl=ENSMMUG00000014227|UniProtKB=P56490	Muscarinic acetylcholine receptor M5	IDA	11166329	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	10395542	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DANRE|ZFIN=ZDB-GENE-000330-4|UniProtKB=Q1MTI1	Uncharacterized protein	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00056	VEGF signaling pathway	P01411	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00019	Endothelin signaling pathway	P00586	Gq	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P06959	CCKR signaling map	P07088	RYR1/2/3	HUMAN|HGNC=10483|UniProtKB=P21817	Ryanodine receptor 1	RCA	16786171	PubMed	PTHR13715:SF15	RYANODINE RECEPTOR 1
P00021	FGF signaling pathway	P00648	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00012	Cadherin signaling pathway	P00471	Cadherin	BOVIN|Ensembl=ENSBTAG00000014488|UniProtKB=E1BF53	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF91	CADHERIN-7
P00057	Wnt signaling pathway	P01457	GBeta	DICPU|Gene=DICPUDRAFT_93216|UniProtKB=F1A421	Guanine nucleotide-binding protein subunit beta	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	SCHPO|PomBase=SPAC22F8.11|UniProtKB=P40977	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1	TAS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	HUMAN|HGNC=17780|UniProtKB=Q562R1	Beta-actin-like protein 2	IC	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	SCHMA|EnsemblGenome=Smp_059340|UniProtKB=C4QDC7	Guanine nucleotide-binding protein G(S) subunit alpha (Adenylate cyclase-stimulating G alpha protein),putative	IC	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00020	FAS signaling pathway	P00608	Pro-Caspase3	MACMU|Ensembl=ENSMMUG00000012053|UniProtKB=F7HFY2	Uncharacterized protein	ISS	9323209	PubMed	PTHR10454:SF198	CASPASE-3
P00009	Axon guidance mediated by netrin	P00363	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00010	B cell activation	P00381	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00566	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IGI	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00591	PLCbeta	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00187	beta catenin	XENTR|Xenbase=XB-GENE-487200|UniProtKB=Q28GC2	Catenin (Cadherin associated protein), beta 1, 88kDa	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P05918	p38 MAPK pathway	P06020	p38delta	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	14744428	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MACMU|Ensembl=ENSMMUG00000006611|UniProtKB=F7HMF6	Uncharacterized protein	ISS	12130679	PubMed	PTHR24228:SF25	B2 BRADYKININ RECEPTOR
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	PANTR|Gene=CHRM2|UniProtKB=Q9N2A7	Muscarinic acetylcholine receptor M2 (Fragment)	ISS	91373358	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00046	Oxidative stress response	P01131	MKP5	CANLF|Ensembl=ENSCAFG00000030565|UniProtKB=J9P4K8	Dual specificity protein phosphatase	ISS			PTHR10159:SF40	DUAL SPECIFICITY PROTEIN PHOSPHATASE 5
P00010	B cell activation	P00398	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IGI	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00012	Cadherin signaling pathway	P00470	F-actin	CANLF|Ensembl=ENSCAFG00000015708|UniProtKB=F2Z4N0	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	HUMAN|HGNC=4593|UniProtKB=Q13255	Metabotropic glutamate receptor 1	ISS	12488551	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P02762	Pentose phosphate pathway	P03079	Hexokinase	MACMU|Ensembl=ENSMMUG00000003849|UniProtKB=F7HAC6	Uncharacterized protein	RCA			PTHR19443:SF28	HEXOKINASE HKDC1-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05912	Dopamine receptor mediated signaling pathway	P05966	EPB41	HUMAN|HGNC=3377|UniProtKB=P11171	Protein 4.1	IPI	12181426	PubMed	PTHR23280:SF12	PROTEIN 4.1
P00029	Huntington disease	P00796	Kainate receptor	MOUSE|MGI=MGI=95818|UniProtKB=Q61626	Glutamate receptor ionotropic, kainate 5	IDA	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00053	T cell activation	P01331	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00037	Ionotropic glutamate receptor pathway	P01018	Glu1	MOUSE|MGI=MGI=95808|UniProtKB=P23818	Glutamate receptor 1	ISS	10331083	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00021	FGF signaling pathway	P00624	14-3-3	MACMU|Ensembl=ENSMMUG00000013206|UniProtKB=F6XFG9	14-3-3 protein beta/alpha	ISS	10407019	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00019	Endothelin signaling pathway	P00589	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12539654	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00814	P300	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00010	B cell activation	P00391	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00014	Cholesterol biosynthesis	P00491	Hydroxymethyl glutaryl CoA reductase	BOVIN|Ensembl=ENSBTAG00000007840|UniProtKB=A7Z064	3-hydroxy-3-methylglutaryl-coenzyme A reductase	ISS	P00347	SPACC	PTHR10572:SF2	3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CAEEL|WormBase=WBGene00003232|UniProtKB=Q09630	Probable metabotropic glutamate receptor mgl-1	IDA			PTHR24060:SF137	METABOTROPIC GLUTAMATE RECEPTOR
P00057	Wnt signaling pathway	P01465	Ggamma	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00059	p53 pathway	G01568	KILLER/DR5	HUMAN|HGNC=11904|UniProtKB=O00220	Tumor necrosis factor receptor superfamily member 10A	IGI	11498783	PubMed	PTHR23097:SF179	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10A
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	CHICK|Ensembl=ENSGALG00000026034|UniProtKB=Q9PWA0	Regulator of G-protein signaling 17	IDA	8756726	PubMed	PTHR10845:SF196	REGULATOR OF G-PROTEIN SIGNALING 17
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05918	p38 MAPK pathway	P06044	GADD45	MONDO|Ensembl=ENSMODG00000000788|UniProtKB=F6SSE6	Uncharacterized protein	ISS	10097101	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00584	Gs	CHICK|Ensembl=ENSGALG00000013785|UniProtKB=E1BS74	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	XENTR|Xenbase=XB-GENE-494548|UniProtKB=F7EC26	Uncharacterized protein	ISS	10825661	PubMed	PTHR24070:SF186	GTPASE KRAS
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MACMU|Ensembl=ENSMMUG00000019112|UniProtKB=F6T8S6	N-methyl D-aspartate receptor subtype 2B	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00011	Blood coagulation	P00429	PN2	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	ISS	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BOVIN|Ensembl=ENSBTAG00000014614|UniProtKB=P62739	Actin, aortic smooth muscle	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00010	B cell activation	P00381	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	IDA	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04393	Ras Pathway	P04570	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IDA	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	XENTR|Xenbase=XB-GENE-491618|UniProtKB=Q6P378	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00021	FGF signaling pathway	P00623	FGF	HUMAN|HGNC=3673|UniProtKB=O60258	Fibroblast growth factor 17	ISS	9514906	PubMed	PTHR11486:SF71	FIBROBLAST GROWTH FACTOR 17
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CAEEL|WormBase=WBGene00000043|UniProtKB=Q93149	Acetylcholine receptor subunit beta-type acr-3	IC	22213672	PubMed	PTHR18945:SF771	ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 1
P00052	TGF-beta signaling pathway	P01284	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	BOVIN|Ensembl=ENSBTAG00000009405|UniProtKB=P79100	Short transient receptor potential channel 4	IDA	11055438	PubMed	PTHR10117:SF25	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 4
P00006	Apoptosis signaling pathway	P00311	GCKR	MACMU|Ensembl=ENSMMUG00000013901|UniProtKB=F6QWT4	Mitogen-activated protein kinase kinase kinase kinase	ISS			PTHR24361:SF205	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 3
P00006	Apoptosis signaling pathway	P00314	MKK3	MOUSE|MGI=MGI=1346868|UniProtKB=O09110	Dual specificity mitogen-activated protein kinase kinase 3	IDA	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00048	PI3 kinase pathway	P01202	p85	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04393	Ras Pathway	P04570	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00011	Blood coagulation	P00409	PAI-2	HUMAN|HGNC=8584|UniProtKB=P05120	Plasminogen activator inhibitor 2	ISS	11929770	PubMed	PTHR11461:SF61	PLASMINOGEN ACTIVATOR INHIBITOR 2
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00049	Parkinson disease	P01230	Src kinase	STRPU|EnsemblGenome=SPU_013522|UniProtKB=Q8WQM5	Tyrosine-protein kinase	IDA	8054685	PubMed	PTHR24418:SF292	TYROSINE-PROTEIN KINASE SRC42A
P00047	PDGF signaling pathway	P01174	Rho	RAT|RGD=1306068|UniProtKB=D4A6C5	Protein Arhgap1	ISS	14724572	PubMed	PTHR23176:SF28	RHO GTPASE-ACTIVATING PROTEIN 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	IC	11956331	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	PANTR|Ensembl=ENSPTRG00000012514|UniProtKB=H2QIT0	Serine/threonine-protein kinase receptor	ISS	11252892	PubMed	PTHR23255:SF64	ACTIVIN RECEPTOR TYPE-2A
P00018	EGF receptor signaling pathway	P00558	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00013	Cell cycle	P00483	Cyclin E	DANRE|ZFIN=ZDB-GENE-980526-168|UniProtKB=P47794	G1/S-specific cyclin-E1	NAS	18858511	gi	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00003	Alzheimer disease-amyloid secretase pathway	P00094	BACE-1 pro-domain	MOUSE|MGI=MGI=1346542|UniProtKB=P56818	Beta-secretase 1	IDA	10956649	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00005	Angiogenesis	P00206	Wnt	DROME|FlyBase=FBgn0004009|UniProtKB=P09615	Protein wingless	ISS	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00018	EGF receptor signaling pathway	P00541	Spry	MACMU|Ensembl=ENSMMUG00000014175|UniProtKB=F7ALK4	Uncharacterized protein	ISS	99264295	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P00047	PDGF signaling pathway	P01154	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P06959	CCKR signaling map	P07148	Protein tyrosine sulfotransferase	HUMAN|HGNC=12020|UniProtKB=O60507	Protein-tyrosine sulfotransferase 1	RCA	12479974	PubMed	PTHR12788:SF4	PROTEIN-TYROSINE SULFOTRANSFERASE 1
P06959	CCKR signaling map	G06978	CHGA	HUMAN|HGNC=1929|UniProtKB=P10645	Chromogranin-A	RCA	17889508	PubMed	PTHR10583:SF1	CHROMOGRANIN-A
P00046	Oxidative stress response	P01131	MKP5	CHICK|Ensembl=ENSGALG00000009450|UniProtKB=F1NXH3	Uncharacterized protein	TAS	11856337	PubMed	PTHR10159:SF299	DUAL SPECIFICITY PROTEIN PHOSPHATASE 10
P00019	Endothelin signaling pathway	P00580	ET-RA/B	HUMAN|HGNC=3179|UniProtKB=P25101	Endothelin-1 receptor	IGI	12875994	PubMed	PTHR24243:SF31	ENDOTHELIN-1 RECEPTOR
P00034	Integrin signalling pathway	P00951	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01458	Protein Kinase C	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	RAT|RGD=2744|UniProtKB=P31422	Metabotropic glutamate receptor 3	IDA			PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9408|UniProtKB=O94806	Serine/threonine-protein kinase D3	ISS	12676944	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P06959	CCKR signaling map	G06969	HDC	HUMAN|HGNC=4855|UniProtKB=P19113	Histidine decarboxylase	RCA	8928792	PubMed	PTHR11999:SF68	HISTIDINE DECARBOXYLASE
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=102967|UniProtKB=Q61184	Melatonin receptor type 1A	ISS			PTHR43962:SF2	MELATONIN RECEPTOR TYPE 1A
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	ARATH|TAIR=AT4G14880|UniProtKB=P47998	Cysteine synthase 1	ISS			PTHR10314:SF160	CYSTEINE SYNTHASE 1-RELATED
P00017	DNA replication	P00527	Histones	MONBE|Gene=20088|UniProtKB=A9UTW8	Histone H3	ISS	12413958	PubMed	PTHR11426:SF169	HISTONE H3
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01164	PDK1/2	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00059	p53 pathway	P04633	P110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02736	Coenzyme A biosynthesis	P02884	Dephospho-CoA kinase	CAEEL|WormBase=WBGene00011500|UniProtKB=P34558	Uncharacterized protein T05G5.5	ISS			PTHR10695:SF35	DEPHOSPHO-COA KINASE DOMAIN-CONTAINING PROTEIN
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00049	Parkinson disease	P01211	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00790	beta-Tubulin	ORYSJ|EnsemblGenome=OS03G0105600|UniProtKB=Q8H7U1	Tubulin beta-2 chain	TAS	12932731	PubMed	PTHR11588:SF178	TUBULIN BETA-7 CHAIN
P00021	FGF signaling pathway	P00640	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000012820|UniProtKB=F1MDL3	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00053	T cell activation	P01312	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000008751|UniProtKB=H2QC89	Uncharacterized protein	ISS	129387	gi	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P02778	Sulfate assimilation	P03167	Sulfate adenylyltransferase	BOVIN|Ensembl=ENSBTAG00000012961|UniProtKB=Q3T0J0	3'-phosphoadenosine 5'-phosphosulfate synthase 1	ISS			PTHR11055:SF17	BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06807	gnai	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	RCA	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P02781	Threonine biosynthesis	P03188	Homoserine dehydrogenase	BACSU|EnsemblGenome=BSU32260|UniProtKB=P19582	Homoserine dehydrogenase	ISS			PTHR43331:SF1	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02749	Leucine biosynthesis	P02999	2-Isopropylmalate synthase	RHOBA|EnsemblGenome=RB12756|UniProtKB=Q7UI51	2-isopropylmalate synthase	ISS			PTHR10277:SF9	2-ISOPROPYLMALATE SYNTHASE 1, CHLOROPLASTIC-RELATED
P04392	P53 pathway feedback loops 1	P04539	p53	BOVIN|Ensembl=ENSBTAG00000001069|UniProtKB=P67939	Cellular tumor antigen p53	TAS	14744434	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00025	Hedgehog signaling pathway	P00682	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00013	Cell cycle	P00481	APC	XENTR|Xenbase=XB-GENE-947005|UniProtKB=Q28GX7	Anaphase-promoting complex subunit 10	ISS	14732115	gi	PTHR12936:SF0	ANAPHASE-PROMOTING COMPLEX SUBUNIT 10
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00029	Huntington disease	P00778	NMDA receptor	HUMAN|HGNC=4584|UniProtKB=Q05586	Glutamate receptor ionotropic, NMDA 1	IDA	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	CAEEL|WormBase=WBGene00004958|UniProtKB=Q01608	Presenilin spe-4	TAS	8755489	PubMed	PTHR10202:SF17	PRESENILIN SPE-4
P00029	Huntington disease	P00807	Actin	CHLRE|EnsemblGenome=CHLREDRAFT_24392|UniProtKB=A8JAV1	Actin	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00053	T cell activation	P01332	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01411	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P02749	Leucine biosynthesis	P03002	Isopropylmalate isomerase	MYCTU|EnsemblGenome=Rv2988c|UniProtKB=P9WQF5	3-isopropylmalate dehydratase large subunit	ISS			PTHR43822:SF2	HOMOACONITASE, MITOCHONDRIAL
P00029	Huntington disease	P00775	Rac	ORYSJ|Gene=Os01g0229400|UniProtKB=Q9SSX0	Rac-like GTP-binding protein 1	TAS			PTHR24072:SF154	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00591	PLCbeta	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00034	Integrin signalling pathway	P00912	Arp2/3	MOUSE|MGI=MGI=1923959|UniProtKB=Q9CVB6	Actin-related protein 2/3 complex subunit 2	ISS	12473693	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00048	PI3 kinase pathway	P01182	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00006	Apoptosis signaling pathway	P00268	GCK	RAT|RGD=1305463|UniProtKB=D3Z8I4	Mitogen-activated protein kinase kinase kinase kinase	ISS			PTHR24361:SF88	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MOUSE|MGI=MGI=106212|UniProtKB=Q8BMN3	Neuronal acetylcholine receptor subunit beta-3	IC	85270494	PubMed	PTHR18945:SF75	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CHICK|Ensembl=ENSGALG00000006576|UniProtKB=E1BUE5	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	10553940	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CANLF|Ensembl=ENSCAFG00000029321|UniProtKB=J9P5H0	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00034	Integrin signalling pathway	P00924	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	RAT|RGD=1311192|UniProtKB=A0A0G2K3R1	Protein Map3k4	ISS	97236778	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	MACMU|Ensembl=ENSMMUG00000000342|UniProtKB=F6YMR3	Uncharacterized protein	ISS	11055438	PubMed	PTHR10117:SF9	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 7
P00018	EGF receptor signaling pathway	P00564	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00019	Endothelin signaling pathway	P00586	Gq	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Ensembl=ENSGALG00000011086|UniProtKB=P68139	Actin, alpha skeletal muscle	ISS	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P05734	Synaptic vesicle trafficking	P05773	Munc13	RAT|RGD=628593|UniProtKB=Q9R189	Protein unc-13 homolog D	TAS	608897	OMIM	PTHR10774:SF98	PROTEIN UNC-13 HOMOLOG D
P00004	Alzheimer disease-presenilin pathway	P00168	E-cadherin intracellular fragment	HUMAN|HGNC=1762|UniProtKB=P22223	Cadherin-3	IDA	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00049	Parkinson disease	P01208	Hsp70	CHLTR|EnsemblGenome=CT_396|UniProtKB=P17821	Chaperone protein DnaK	IDA	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	P01437	TCF	PANTR|Ensembl=ENSPTRG00000017236|UniProtKB=H2QRH6	Uncharacterized protein	ISS	11266476	PubMed	PTHR10373:SF33	TRANSCRIPTION FACTOR 7
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00047	PDGF signaling pathway	P01167	Ets	BOVIN|Ensembl=ENSBTAG00000002341|UniProtKB=A5PJG9	ETS1 protein	ISS	15579511	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04396	Vitamin D metabolism and pathway	P04606	VDR	CANLF|Ensembl=ENSCAFG00000009103|UniProtKB=F1PKD9	Uncharacterized protein	ISS	11705326	PubMed	PTHR24082:SF38	VITAMIN D3 RECEPTOR
P05916	Opioid prodynorphin pathway	P06000	vasopressin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MOUSE|MGI=MGI=1202879|UniProtKB=Q924A0	Transcription factor 7-like 2	IEP	9118222	PubMed	PTHR10373:SF32	TRANSCRIPTION FACTOR 7-LIKE 2
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	MOUSE|MGI=MGI=94926|UniProtKB=P51436	D(4) dopamine receptor	ISS	11248120	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00048	PI3 kinase pathway	P01179	PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02743	Formyltetrahydroformate biosynthesis	P02954	Thymidylate synthase	TRYB2|Gene=Tb927.7.5480|UniProtKB=Q582G3	Bifunctional dihydrofolate reductase-thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00057	Wnt signaling pathway	P01444	Wnt	BOVIN|Ensembl=ENSBTAG00000013990|UniProtKB=F1MN70	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P00025	Hedgehog signaling pathway	P00692	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00048	PI3 kinase pathway	P01189	PTEN	DROME|FlyBase=FBgn0026379|UniProtKB=Q7KMQ6	IP16020p	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04384	Gamma-aminobutyric acid synthesis	P04482	Glutamate decarboxylase	DROME|FlyBase=FBgn0036975|UniProtKB=Q9VPH6	CG5618, isoform A	ISS			PTHR11999:SF114	CYSTEINE SULFINIC ACID DECARBOXYLASE
P00029	Huntington disease	P00778	NMDA receptor	MACMU|Ensembl=ENSMMUG00000001661|UniProtKB=F7GR69	Uncharacterized protein	ISS	11554554	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00047	PDGF signaling pathway	P01160	IP3 receptor	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05918	p38 MAPK pathway	P06040	MSK1	HUMAN|HGNC=10434|UniProtKB=O75582	Ribosomal protein S6 kinase alpha-5	RCA	9687510	PubMed	PTHR24351:SF115	RIBOSOMAL PROTEIN S6 KINASE ALPHA-5
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00056	VEGF signaling pathway	P01417	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PANTR|Ensembl=ENSPTRG00000015191|UniProtKB=H2QN23	Uncharacterized protein	ISS			PTHR13140:SF575	MYOSIN-15
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	CHICK|Ensembl=ENSGALG00000003498|UniProtKB=Q5ZMS1	Transcription initiation factor TFIID subunit 8	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	ARATH|TAIR=AT5G07880|UniProtKB=Q9SD96	SNAP25 homologous protein SNAP29	IC			PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00038	JAK/STAT signaling pathway	P01033	PTP	PANTR|Ensembl=ENSPTRG00000001817|UniProtKB=H2Q0U9	Uncharacterized protein	ISS	8940015	PubMed	PTHR19134:SF284	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C
P00036	Interleukin signaling pathway	P00990	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00015	Circadian clock system	G01500	bmal1	CHICK|Ensembl=ENSGALG00000005378|UniProtKB=Q9I8T7	Aryl hydrocarbon receptor nuclear translocator-like protein 1	ISS	11163178	PubMed	PTHR23042:SF52	ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CANLF|Gene=GRIN1|UniProtKB=Q5R1P0	Glutamate receptor ionotropic, NMDA 1	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00056	VEGF signaling pathway	P01411	Ras	DICPU|Gene=DICPUDRAFT_91367|UniProtKB=F0ZB76	Putative uncharacterized protein rasD	ISS	85024887	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00010	B cell activation	P00367	NFAT	MACMU|Ensembl=ENSMMUG00000012657|UniProtKB=F7E7J1	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	DROME|FlyBase=FBgn0032248|UniProtKB=Q9VKV8	Cilia- and flagella-associated protein 20	ISS			PTHR12458:SF8	CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20
P00048	PI3 kinase pathway	P01192	p110	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04398	p53 pathway feedback loops 2	P04668	p53	BOVIN|Ensembl=ENSBTAG00000001069|UniProtKB=P67939	Cellular tumor antigen p53	TAS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00019	Endothelin signaling pathway	P00572	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	CANLF|Ensembl=ENSCAFG00000000934|UniProtKB=E2RT85	Uncharacterized protein	ISS	10778855	PubMed	PTHR44557:SF1	COLLAGEN ALPHA-1 XIV  CHAIN
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00641	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00021	FGF signaling pathway	P00633	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05730	Endogenous cannabinoid signaling	P05746	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00005	Angiogenesis	P00254	GTPase	XENTR|Xenbase=XB-GENE-941426|UniProtKB=Q28HZ4	Novel Rho protein	ISS	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	8170357	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	MOUSE|MGI=MGI=88276|UniProtKB=Q02248	Catenin beta-1	TAS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000009389|UniProtKB=F7HEV7	Uncharacterized protein	ISS	12093103	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	PANTR|Ensembl=ENSPTRG00000009085|UniProtKB=H2RDQ2	Uncharacterized protein	ISS	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CANLF|Ensembl=ENSCAFG00000016787|UniProtKB=F6V9G5	Uncharacterized protein	ISS			PTHR19957:SF97	SYNTAXIN-4
P00018	EGF receptor signaling pathway	P00539	14-3-3	DANRE|ZFIN=ZDB-GENE-011115-1|UniProtKB=Q6PC29	14-3-3 protein gamma-1	ISS	10407019	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	HUMAN|HGNC=4597|UniProtKB=P41594	Metabotropic glutamate receptor 5	ISS	92317054	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00056	VEGF signaling pathway	P01411	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00048	PI3 kinase pathway	P01179	PKB	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00474	Wnt	BOVIN|Ensembl=ENSBTAG00000016012|UniProtKB=F1N5R1	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P06587	Nicotine pharmacodynamics pathway	P06606	ADCY2	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	CHICK|Ensembl=ENSGALG00000000707|UniProtKB=F1NR71	Uncharacterized protein	ISS			PTHR10540:SF7	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8668|UniProtKB=Q9Y5H9	Protocadherin alpha-2	IDA	8120095	PubMed	PTHR24028:SF60	PROTOCADHERIN ALPHA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01089	VAChT	ANOGA|EnsemblGenome=AGAP003684|UniProtKB=A0NDL1	AGAP003684-PA	IC	21863848	PubMed	PTHR23506:SF4	PORTABELLA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IDA	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00005	Angiogenesis	P00215	Nck	MACMU|Ensembl=ENSMMUG00000007389|UniProtKB=F7E0A3	Cytoplasmic protein NCK1 isoform 1	ISS	12874226	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P00021	FGF signaling pathway	P00648	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IGI	2837282	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00750	Rhodopsin kinase	MACMU|Ensembl=ENSMMUG00000007427|UniProtKB=F6SX33	Rhodopsin kinase	ISS	8260489	PubMed	PTHR24355:SF11	RHODOPSIN KINASE
P00011	Blood coagulation	P00403	EPCR	PANTR|Ensembl=ENSPTRG00000013431|UniProtKB=H2R909	Protein C receptor, endothelial	ISS	13626550	gi	PTHR15349:SF0	ENDOTHELIAL PROTEIN C RECEPTOR
P00059	p53 pathway	P04612	HDAC1	CHICK|Ensembl=ENSGALG00000003297|UniProtKB=P56517	Histone deacetylase 1	IDA	12665570	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00965	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	CANLF|Ensembl=ENSCAFG00000013148|UniProtKB=Q5R1P3	Glutamate receptor ionotropic, NMDA 2B	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MACMU|Gene=CHRM1|UniProtKB=P56489	Muscarinic acetylcholine receptor M1	IDA	8100450	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	GIAIC|EnsemblGenome=GL50803_40817|UniProtKB=A8BV70	Actin related protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00047	PDGF signaling pathway	P01143	ERK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00011	Blood coagulation	P00416	Prothrombin	MOUSE|MGI=MGI=88380|UniProtKB=P19221	Prothrombin	ISS	6753798	gi	PTHR24254:SF10	PROTHROMBIN
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	ISS	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014262|UniProtKB=F7BYS8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P02757	O-antigen biosynthesis	P03046	dTDP-glucose pyrophosphorylase	BACTN|EnsemblGenome=BT_2017|UniProtKB=Q8A669	Glucose-1-phosphate thymidylyltransferase	ISS			PTHR43532:SF1	GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE 1
P00049	Parkinson disease	P01238	14-3-3	RAT|RGD=3980|UniProtKB=P63102	14-3-3 protein zeta/delta	ISS	1499718	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00007	Axon guidance mediated by semaphorins	P00340	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PANTR|Ensembl=ENSPTRG00000006890|UniProtKB=H2Q943	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00029	Huntington disease	P00775	Rac	MOUSE|MGI=MGI=1928370|UniProtKB=P84096	Rho-related GTP-binding protein RhoG	TAS	12932731	PubMed	PTHR24072:SF158	RHO-RELATED GTP-BINDING PROTEIN RHOG
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	IC	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04397	p53 pathway by glucose deprivation	P04641	Akt	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	ISS	12089061	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04546	GSK3	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DROME|FlyBase=FBgn0000489|UniProtKB=P16912	Protein kinase DC2	IC	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04393	Ras Pathway	P04553	PAK	HUMAN|HGNC=8590|UniProtKB=Q13153	Serine/threonine-protein kinase PAK 1	IDA	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	RCA	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01135	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	TAS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	PANTR|Ensembl=ENSPTRG00000018511|UniProtKB=H2QTK7	Tyrosine-protein kinase	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00005	Angiogenesis	P00190	RasGAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	ISS	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00018	EGF receptor signaling pathway	P00562	p38	CAEEL|WormBase=WBGene00004055|UniProtKB=Q17446	Mitogen-activated protein kinase pmk-1	IGI	11274345	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00005	Angiogenesis	P00203	Erk	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00048	PI3 kinase pathway	P01196	PDK1	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	RCA	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	MONDO|Ensembl=ENSMODG00000015573|UniProtKB=F7AIP6	Uncharacterized protein (Fragment)	ISS	12356903	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF31	SUBFAMILY NOT NAMED
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P04626	GADD45	MONDO|Ensembl=ENSMODG00000000788|UniProtKB=F6SSE6	Uncharacterized protein	ISS	9827804	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	XENTR|Xenbase=XB-GENE-481916|UniProtKB=F6YF14	Presenilin	ISS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00029	Huntington disease	P00778	NMDA receptor	HUMAN|HGNC=16767|UniProtKB=Q8TCU5	Glutamate receptor ionotropic, NMDA 3A	IDA	11554549	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00038	JAK/STAT signaling pathway	P01027	STAT	MACMU|Ensembl=ENSMMUG00000017527|UniProtKB=F6UMM2	Signal transducer and activator of transcription	ISS	8085155	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	ARATH|TAIR=AT2G21550|UniProtKB=Q9SIK4	Bifunctional dihydrofolate reductase-thymidylate synthase	ISS			PTHR11548:SF7	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=109356|UniProtKB=O09044	Synaptosomal-associated protein 23	IC	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	ORYSJ|EnsemblGenome=OS01G0271200|UniProtKB=Q9LIZ8	Os01g0271200 protein	ISS			PTHR43097:SF9	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05957	K+ channel	CHICK|Ensembl=ENSGALG00000016193|UniProtKB=E1BYI0	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000007882|UniProtKB=G3X7Z2	Uncharacterized protein	ISS	8386525	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IDA	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00059	p53 pathway	P01481	ATM/ATR	YEAST|SGD=S000000184|UniProtKB=P38110	Serine/threonine-protein kinase TEL1	ISS			PTHR11139:SF72	SERINE-PROTEIN KINASE ATM
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04397	p53 pathway by glucose deprivation	P04641	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00020	FAS signaling pathway	P00608	Pro-Caspase3	RAT|RGD=2275|UniProtKB=P55213	Caspase-3	IGI	9323209	PubMed	PTHR10454:SF198	CASPASE-3
P00048	PI3 kinase pathway	P01179	PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	RAT|RGD=2735|UniProtKB=Q63273	Glutamate receptor ionotropic, kainate 5	ISS	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01281	SARA	HUMAN|HGNC=20756|UniProtKB=Q7Z3T8	Zinc finger FYVE domain-containing protein 16	TAS			PTHR22835:SF43	ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 16
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00875	GEF	HUMAN|HGNC=32594|UniProtKB=Q8TCU6	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein	IDA	11955434	PubMed	PTHR22829:SF6	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE-DEPENDENT RAC EXCHANGER 1 PROTEIN
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00034	Integrin signalling pathway	P00925	MEK	CANLF|Ensembl=ENSCAFG00000018530|UniProtKB=F1PXD3	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	ISS	11889139	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00020	FAS signaling pathway	P00616	Nuclear Lamin	DROME|FlyBase=FBgn0010397|UniProtKB=Q03427	Lamin-C	TAS	11165516	PubMed	PTHR23239:SF234	LAMIN DM0-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02788	Xanthine and guanine salvage pathway	P03249	Guanine deaminase	PSEAE|EnsemblGenome=PA1521|UniProtKB=Q9I3J2	Probable guanine deaminase	ISS	10984043	PubMed	PTHR11271:SF6	GUANINE DEAMINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	ORNAN|Ensembl=ENSOANG00000013961|UniProtKB=F6VPY1	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00060	Ubiquitin proteasome pathway	P01492	E1	SCHPO|PomBase=SPBC16H5.03c|UniProtKB=O42939	Ubiquitin-activating enzyme E1-like	ISS			PTHR10953:SF5	SUMO-ACTIVATING ENZYME SUBUNIT 2
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF31	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00012	Cadherin signaling pathway	P00470	F-actin	PLAF7|EnsemblGenome=PFL2215w|UniProtKB=Q8I4X0	Actin-1	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00004	Alzheimer disease-presenilin pathway	P00141	Membrane metalloprotease	RAT|RGD=620199|UniProtKB=O35548	Matrix metalloproteinase-16	RCA			PTHR10201:SF26	MATRIX METALLOPROTEINASE-16
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	DROME|FlyBase=FBgn0019947|UniProtKB=O02194	Presenilin homolog	IDA	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Gene=DRD2|UniProtKB=P60026	D(2) dopamine receptor	ISS	11861492	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Ensembl=ENSCAFG00000000332|UniProtKB=F1P8E3	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00053	T cell activation	P01300	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05915	Opioid proenkephalin pathway	P05987	peptide F	HUMAN|HGNC=8831|UniProtKB=P01210	Proenkephalin-A	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	BOVIN|Ensembl=ENSBTAG00000003054|UniProtKB=F1MC23	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00054	Toll receptor signaling pathway	P01341	Elk1	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	10487205	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00047	PDGF signaling pathway	P01173	STAT	RAT|RGD=3774|UniProtKB=P52632	Signal transducer and activator of transcription 5B	ISS	8584036	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00012	Cadherin signaling pathway	P00474	Wnt	MONDO|Ensembl=ENSMODG00000010644|UniProtKB=F7D4J8	Protein Wnt (Fragment)	ISS	11266476	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P04393	Ras Pathway	P04547	Ras	XENTR|Xenbase=XB-GENE-494548|UniProtKB=F7EC26	Uncharacterized protein	ISS	10825661	PubMed	PTHR24070:SF186	GTPASE KRAS
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05913	Enkephalin release	P05972	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00552	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IDA	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00011	Blood coagulation	P00454	FVII	DANRE|ZFIN=ZDB-GENE-010814-1|UniProtKB=F1QFP3	Uncharacterized protein	ISS	18858363	gi	PTHR44064:SF1	COAGULATION FACTOR VII
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Ensembl=ENSPTRG00000004233|UniProtKB=H2Q4N9	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00828	Galphai	MACMU|Ensembl=ENSMMUG00000023470|UniProtKB=F6V2U8	Uncharacterized protein	RCA			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	HUMAN|HGNC=4394|UniProtKB=P19087	Guanine nucleotide-binding protein G(t) subunit alpha-2	ISS	10188796	PubMed	PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT4G36450|UniProtKB=O23236	Mitogen-activated protein kinase 14	IDA	11707292	PubMed	PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	CAEEL|WormBase=WBGene00001679|UniProtKB=P17343	Guanine nucleotide-binding protein subunit beta-1	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MONDO|Ensembl=ENSMODG00000014746|UniProtKB=F6YN64	Uncharacterized protein (Fragment)	ISS	10331083	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	RAT|RGD=3187|UniProtKB=Q07008	Neurogenic locus notch homolog protein 1	IDA	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00007	Axon guidance mediated by semaphorins	P00339	CRMP	MACMU|Ensembl=ENSMMUG00000010761|UniProtKB=F7FXK5	Uncharacterized protein	ISS			PTHR11647:SF50	DIHYDROPYRIMIDINASE
P02738	De novo purine biosynthesis	P02900	AICAR transformylase	DROME|FlyBase=FBgn0039241|UniProtKB=Q9VC18	RE29555p	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04393	Ras Pathway	P04544	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12748278	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00029	Huntington disease	P00805	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	STRPU|EnsemblGenome=SPU_003894|UniProtKB=W4XKG7	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF155	TUBULIN BETA-2 CHAIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00577	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IGI	10799299	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00015	Circadian clock system	G01503	per	CANLF|Ensembl=ENSCAFG00000016984|UniProtKB=E2R0I6	Uncharacterized protein	ISS	20570170	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_58093|UniProtKB=C3Z4K3	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P02785	Valine biosynthesis	P03215	Branched chain amino acid aminotransferase	ARATH|TAIR=AT1G50110|UniProtKB=Q9LPM9	Branched-chain-amino-acid aminotransferase 6	ISS			PTHR42825:SF4	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 6-RELATED
P00052	TGF-beta signaling pathway	P01284	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	MACMU|Ensembl=ENSMMUG00000010173|UniProtKB=F7AGU8	Presenilin	ISS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	RAT|RGD=2155|UniProtKB=O88656	Actin-related protein 2/3 complex subunit 1B	ISS	12932731	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P04393	Ras Pathway	P04560	AP1	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	IGI	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P02744	Fructose galactose metabolism	P02960	Galactokinase	MOUSE|MGI=MGI=95730|UniProtKB=Q9R0N0	Galactokinase	IDA	12003984	gi	PTHR10457:SF6	GALACTOKINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06709	FOS	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	RCA	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00059	p53 pathway	P01486	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	TAS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00373	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00010	B cell activation	P00370	NFkappaB	CANLF|Ensembl=ENSCAFG00000010155|UniProtKB=E2RLL2	Uncharacterized protein	ISS	9133421	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00021	FGF signaling pathway	P00645	Rac	CHICK|Ensembl=ENSGALG00000002859|UniProtKB=F6UBD2	Uncharacterized protein	ISS	9252344	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00046	Oxidative stress response	P01129	JNK1/2	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04541	p90RSK	BOVIN|Ensembl=ENSBTAG00000017639|UniProtKB=F1MZW8	Ribosomal protein S6 kinase	ISS	2779569	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000005316|UniProtKB=F7GJQ0	Uncharacterized protein	ISS	11781138	PubMed	PTHR24248:SF24	ALPHA-2A ADRENERGIC RECEPTOR
P00005	Angiogenesis	P00204	PLD	MACMU|Ensembl=ENSMMUG00000023289|UniProtKB=F7FFD2	Uncharacterized protein	ISS	15668389	PubMed	PTHR18896:SF57	PHOSPHOLIPASE D1
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=1765|UniProtKB=P55285	Cadherin-6	IDA	8120095	PubMed	PTHR24027:SF322	CADHERIN-6
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00045	Notch signaling pathway	P01118	Numb	RAT|RGD=620107|UniProtKB=Q2LC84	Protein numb homolog	ISS	10468633	PubMed	PTHR11232:SF33	PROTEIN NUMB HOMOLOG
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	RAT|RGD=628852|UniProtKB=Q02294	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	14507926	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CHICK|Ensembl=ENSGALG00000014539|UniProtKB=F1N861	Uncharacterized protein	ISS	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00588	ET1-4	BOVIN|Ensembl=ENSBTAG00000021434|UniProtKB=Q867A9	Endothelin-2	ISS			PTHR13874:SF9	ENDOTHELIN-2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CAEEL|WormBase=WBGene00001665|UniProtKB=P28052	Guanine nucleotide-binding protein alpha-3 subunit	ISS	12488551	PubMed	PTHR10218:SF245	GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-2 SUBUNIT-RELATED
P00021	FGF signaling pathway	P00633	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IC	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00034	Integrin signalling pathway	P00951	Jnk	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ARATH|TAIR=AT5G59370|UniProtKB=P53494	Actin-4	IDA			PTHR11937:SF366	ACTIN-4
P06664	Gonadotropin-releasing hormone receptor pathway	P06838	CTNNB1	MOUSE|MGI=MGI=88276|UniProtKB=Q02248	Catenin beta-1	RCA	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00006	Apoptosis signaling pathway	P00274	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00048	PI3 kinase pathway	P01202	p85	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P02741	Flavin biosynthesis	P02933	Pyrimidine deaminase	DEIRA|EnsemblGenome=DR_0153|UniProtKB=Q9RY01	Riboflavin biosynthesis protein RibD	ISS			PTHR44288:SF1	RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBD
P00010	B cell activation	P00371	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	MACMU|Ensembl=ENSMMUG00000009054|UniProtKB=F7F735	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CHICK|Ensembl=ENSGALG00000003270|UniProtKB=F1NR31	Uncharacterized protein	IDA			PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P04393	Ras Pathway	P04541	p90RSK	CHICK|Ensembl=ENSGALG00000000366|UniProtKB=P18652	Ribosomal protein S6 kinase 2 alpha	IDA	6755374	gi	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CANLF|Ensembl=ENSCAFG00000012181|UniProtKB=F2Z4N7	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06834	MAP3Ks	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	RCA	12049732	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00059	p53 pathway	P01486	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	MACMU|Ensembl=ENSMMUG00000000289|UniProtKB=F7A9T0	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	CHICK|Ensembl=ENSGALG00000007794|UniProtKB=A9YZQ5	Dopamine receptor 2 protein transcript variant 1	ISS	2137198	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00053	T cell activation	P01309	fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	TAS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00036	Interleukin signaling pathway	P00970	Interleukin	RAT|RGD=68949|UniProtKB=P42203	Interleukin-13	ISS	7916615	PubMed	PTHR45413:SF1	INTERLEUKIN-13
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01465	Ggamma	PANTR|Ensembl=ENSPTRG00000006342|UniProtKB=H2Q8A8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	MACMU|Ensembl=ENSMMUG00000008351|UniProtKB=F7HRV5	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00006	Apoptosis signaling pathway	P00311	GCKR	PANTR|Ensembl=ENSPTRG00000011858|UniProtKB=H2QHS7	Mitogen-activated protein kinase kinase kinase kinase	ISS			PTHR24361:SF205	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 3
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008018|UniProtKB=F7EPG4	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	NEUCR|EnsemblGenome=EFNCRG00000000159|UniProtKB=F5HH30	Guanine nucleotide-binding protein beta subunit	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	BOVIN|Ensembl=ENSBTAG00000020485|UniProtKB=P17870	Beta-arrestin-1	IDA	4757780	gi	PTHR11792:SF22	BETA-ARRESTIN-1
P00046	Oxidative stress response	P01129	JNK1/2	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05918	p38 MAPK pathway	P06020	p38delta	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	87226391	PubMed	PTHR24070:SF385	GTPASE HRAS
P00020	FAS signaling pathway	P00593	Caspase9	MACMU|Ensembl=ENSMMUG00000018163|UniProtKB=F7FNC1	Caspase	ISS	11440972	PubMed	PTHR10454:SF157	CASPASE-9
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00627	ERK1-2	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02770	Pyridoxal phosphate salvage pathway	P03122	Pyridoxamine kinase	MACMU|Ensembl=ENSMMUG00000012300|UniProtKB=F7DLS4	Uncharacterized protein	ISS	15082224	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MOUSE|MGI=MGI=95818|UniProtKB=Q61626	Glutamate receptor ionotropic, kainate 5	ISS	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	RCA	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	PANTR|Ensembl=ENSPTRG00000020039|UniProtKB=H2R9W1	Uncharacterized protein	ISS	11443533	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04395	Vasopressin synthesis	P04594	Neurophysin	TAKRU|Ensembl=ENSTRUG00000015413|UniProtKB=H2UR30	Uncharacterized protein	ISS			PTHR11681:SF13	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00005	Angiogenesis	P00220	c-Jun	XENTR|Xenbase=XB-GENE-482228|UniProtKB=F6RYL1	Uncharacterized protein	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	MOUSE|MGI=MGI=109482|UniProtKB=P97445	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	14624853	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00005	Angiogenesis	P00203	Erk	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00641	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00013	Cell cycle	P00481	APC	TAKRU|Ensembl=ENSTRUG00000017519|UniProtKB=H2V6S6	Anaphase-promoting complex subunit 10	ISS	14732115	gi	PTHR12936:SF0	ANAPHASE-PROMOTING COMPLEX SUBUNIT 10
P00054	Toll receptor signaling pathway	P01368	MKK2	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02918	dUTP pyrophosphatase	MOUSE|MGI=MGI=1346051|UniProtKB=Q8VCG1	Deoxyuridine triphosphatase, isoform CRA_b	ISS			PTHR11241:SF6	DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE, MITOCHONDRIAL
P00034	Integrin signalling pathway	P00922	Collagen	BOVIN|Ensembl=ENSBTAG00000013103|UniProtKB=P02453	Collagen alpha-1(I) chain	ISS	10778855	PubMed	PTHR24023:SF569	COLLAGEN ALPHA-1 I  CHAIN
P00059	p53 pathway	G04694	p110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IDA			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00828	Galphai	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	RCA			PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	ISS	10188796	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02726	Aminobutyrate degradation	P02825	4-aminobutyrate aminotransferase	PANTR|Ensembl=ENSPTRG00000007746|UniProtKB=H2QAJ4	4-aminobutyrate aminotransferase	ISS	8133261	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P05915	Opioid proenkephalin pathway	P05990	K+ channel	MACMU|Ensembl=ENSMMUG00000005826|UniProtKB=F6VE51	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=621516|UniProtKB=G3V6P8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P06664	Gonadotropin-releasing hormone receptor pathway	P06831	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	RCA	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00005	Angiogenesis	P00193	SOS-1	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-2280|UniProtKB=Q6P025	Gnb3 protein	ISS			PTHR19850:SF35	GNB3 PROTEIN
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00029	Huntington disease	P00805	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=14265|UniProtKB=Q86UP0	Cadherin-24	IDA	8120095	PubMed	PTHR24027:SF272	CADHERIN-24
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00243	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00004	Alzheimer disease-presenilin pathway	P00128	Erb-B4	MOUSE|MGI=MGI=104771|UniProtKB=Q61527	Receptor tyrosine-protein kinase erbB-4	ISS	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	PYRAE|EnsemblGenome=PAE2865|UniProtKB=Q8ZUB3	Acetyl-coenzyme A synthetase	ISS			PTHR24095:SF232	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01421	Rac	RAT|RGD=1307954|UniProtKB=Q5FVG6	Proline-rich protein 5	ISS			PTHR32428:SF4	PROLINE-RICH PROTEIN 5
P04393	Ras Pathway	P04558	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	IDA	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00048	PI3 kinase pathway	P01194	S6K	BOVIN|Gene=RPS6KB1|UniProtKB=Q6TJY3	Ribosomal protein S6 kinase beta-1	ISS	11861821	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Ensembl=ENSGALG00000003157|UniProtKB=E1C523	Uncharacterized protein	IEP	89264452	PubMed	PTHR13140:SF358	MYOSIN-7B
P00054	Toll receptor signaling pathway	P01357	MEKK1	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	ISS	8940199	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	RAT|RGD=1304749|UniProtKB=A0A0G2K0H3	Protein Lrp6	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04578	Rho	HUMAN|HGNC=667|UniProtKB=P61586	Transforming protein RhoA	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00053	T cell activation	P01320	PLC-gamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00053	T cell activation	P01311	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04566	Stat 1/3	RAT|RGD=3772|UniProtKB=P52631	Signal transducer and activator of transcription 3	IDA	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04385	Histamine H1 receptor mediated signaling pathway	P04485	H1	BOVIN|Gene=HRH1|UniProtKB=P30546	Histamine H1 receptor	ISS	2670975	PubMed	PTHR43914:SF2	HISTAMINE H1 RECEPTOR
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01320	PLC-gamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	CANLF|Ensembl=ENSCAFG00000015662|UniProtKB=E2RHY4	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	MOUSE|MGI=MGI=1920334|UniProtKB=Q8C015	Serine/threonine-protein kinase PAK 7	ISS			PTHR24361:SF183	SERINE/THREONINE-PROTEIN KINASE PAK 7
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IC	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00547	PP2A	EMENI|EnsemblGenome=CADANIAG00006588|UniProtKB=Q9HFQ2	Serine/threonine-protein phosphatase PP2A catalytic subunit	NAS			PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MACMU|Ensembl=ENSMMUG00000017374|UniProtKB=F7H6T7	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	CHICK|Gene=ACVR2B|UniProtKB=Q90670	Activin receptor type-2B	TAS	11252892	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DANRE|ZFIN=ZDB-GENE-000920-1|UniProtKB=A5WW41	Uncharacterized protein	IEP	20393975	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MOUSE|MGI=MGI=95778|UniProtKB=P20612	Guanine nucleotide-binding protein G(t) subunit alpha-1	ISS	10188796	PubMed	PTHR10218:SF67	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-1
P00037	Ionotropic glutamate receptor pathway	P01021	Vglut	RAT|RGD=620531|UniProtKB=Q9JI12	Vesicular glutamate transporter 2	ISS	12815758	PubMed	PTHR11662:SF201	VESICULAR GLUTAMATE TRANSPORTER 2
P00056	VEGF signaling pathway	P01407	Erk	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00054	Toll receptor signaling pathway	P01375	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00223	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MONDO|Ensembl=ENSMODG00000023470|UniProtKB=F6T6U1	Uncharacterized protein	ISS	12181435	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P04376	5HT4 type receptor mediated signaling pathway	P04426	K+ channel	MACMU|Ensembl=ENSMMUG00000005826|UniProtKB=F6VE51	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00019	Endothelin signaling pathway	P00586	Gq	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04393	Ras Pathway	P04569	Cdc42	HUMAN|HGNC=1736|UniProtKB=P60953	Cell division control protein 42 homolog	IDA	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00029	Huntington disease	P00780	Microtubule	BOVIN|Ensembl=ENSBTAG00000006969|UniProtKB=Q2KJD0	Tubulin beta-5 chain	ISS	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00036	Interleukin signaling pathway	P00981	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ORNAN|Ensembl=ENSOANG00000007405|UniProtKB=F7CIV4	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	ARATH|TAIR=AT4G20890|UniProtKB=P29517	Tubulin beta-9 chain	ISS	12932731	PubMed	PTHR11588:SF245	TUBULIN BETA-4 CHAIN-RELATED
P00006	Apoptosis signaling pathway	P00269	MAPK	ORYSJ|EnsemblGenome=OS06G0699400|UniProtKB=Q5Z859	Mitogen-activated protein kinase 4	ISS	9836510	gi	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	MOUSE|MGI=MGI=96770|UniProtKB=P27782	Lymphoid enhancer-binding factor 1	TAS	9039917	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	14526383	PubMed	PTHR10048:SF14	PI-3 KINASE
P00005	Angiogenesis	P00203	Erk	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347736|UniProtKB=E9FRT1	Muscle-specific actin	ISS	14684598	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	DICDI|dictyBase=DDB_G0268744|UniProtKB=Q55EU6	Putative actin-23	IC	14684598	PubMed	PTHR11937:SF154	ACTIN-17-RELATED
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01189	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00019	Endothelin signaling pathway	P00590	IP3 R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00005	Angiogenesis	P00190	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	20908895	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-070112-342|UniProtKB=A1L271	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00029	Huntington disease	P00778	NMDA receptor	HUMAN|HGNC=4587|UniProtKB=Q14957	Glutamate receptor ionotropic, NMDA 2C	IDA	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	IDA	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00019	Endothelin signaling pathway	P00572	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00048	PI3 kinase pathway	P01188	Gbetagamma	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04393	Ras Pathway	P04542	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01443	Phospholipase C	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00059	p53 pathway	P01486	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	TAS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	SCLS1|Gene=SS1G_08733|UniProtKB=A7ETS6	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000021434|UniProtKB=F7CB49	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	BOVIN|Ensembl=ENSBTAG00000035697|UniProtKB=Q28024	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P02787	Vitamin B6 metabolism	P03236	Pyridoxamine phosphate oxidase	ECOLI|EcoGene=EG11487|UniProtKB=P0AFI7	Pyridoxine/pyridoxamine 5'-phosphate oxidase	IDA	11786019	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00057	Wnt signaling pathway	P01428	Frizzled	MONDO|Ensembl=ENSMODG00000010505|UniProtKB=F7E9U1	Uncharacterized protein (Fragment)	ISS	8717036	PubMed	PTHR11309:SF81	FRIZZLED-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g234494|UniProtKB=A7RU31	Predicted protein	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	HUMAN|HGNC=130|UniProtKB=P62736	Actin, aortic smooth muscle	IC	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00005	Angiogenesis	P00203	Erk	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01154	Ras	CHICK|Ensembl=ENSGALG00000014033|UniProtKB=E1BTS2	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	HUMAN|HGNC=10004|UniProtKB=O75916	Regulator of G-protein signaling 9	IDA	8756726	PubMed	PTHR10845:SF170	REGULATOR OF G-PROTEIN SIGNALING 9
P02757	O-antigen biosynthesis	P03045	dTDP-glucose 4,6-dehydratase	BOVIN|Ensembl=ENSBTAG00000005309|UniProtKB=A6QLW2	dTDP-D-glucose 4,6-dehydratase	ISS			PTHR43000:SF7	DTDP-D-GLUCOSE 4,6-DEHYDRATASE
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	CHICK|Ensembl=ENSGALG00000006638|UniProtKB=R4GGL9	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00559	MEK1-2	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00807	Actin	DANRE|ZFIN=ZDB-GENE-040625-35|UniProtKB=Q6IQL9	Novel actin protein	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00018	EGF receptor signaling pathway	P00560	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04392	P53 pathway feedback loops 1	P04539	p53	RAT|RGD=620863|UniProtKB=Q9JJP6	Tumor protein 63	TAS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00025	Hedgehog signaling pathway	P00692	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00047	PDGF signaling pathway	P01175	Shc	MOUSE|MGI=MGI=98296|UniProtKB=P98083	SHC-transforming protein 1	ISS	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00012	Cadherin signaling pathway	P00462	Casein kinase II	RAT|RGD=1306882|UniProtKB=B4F7A9	Casein kinase 2, alpha prime polypeptide	ISS	10806215	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DROME|FlyBase=FBgn0010333|UniProtKB=P40792	Ras-related protein Rac1	ISS	4757952	gi	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00005	Angiogenesis	P00256	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00053	T cell activation	P01331	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IDA	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00036	Interleukin signaling pathway	P00971	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	11384839	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	DANRE|Ensembl=ENSDARG00000059090|UniProtKB=E7FDL0	Uncharacterized protein	ISS	12181435	PubMed	PTHR24229:SF75	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00021	FGF signaling pathway	P00644	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IGI	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=7574|UniProtKB=Q9Y623	Myosin-4	IC	89264452	PubMed	PTHR13140:SF681	MYOSIN-4
P00047	PDGF signaling pathway	P01155	Jak	MONDO|Ensembl=ENSMODG00000015373|UniProtKB=F6WH53	Tyrosine-protein kinase	ISS	22482294	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	DROME|FlyBase=FBgn0002842|UniProtKB=Q9VP40	Spermatocyte arrest	ISS	604904	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CANLF|Ensembl=ENSCAFG00000000185|UniProtKB=E2R4Q2	Uncharacterized protein	ISS	14570579	PubMed	PTHR19957:SF90	SYNTAXIN-7
P00010	B cell activation	P00383	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00048	PI3 kinase pathway	P01198	FOXO	BOVIN|Ensembl=ENSBTAG00000011234|UniProtKB=F1N4K5	Uncharacterized protein	ISS	15031210	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	CHICK|Ensembl=ENSGALG00000011452|UniProtKB=F1P1K3	Uncharacterized protein	ISS	12473693	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00034	Integrin signalling pathway	P00907	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	RAT|RGD=619966|UniProtKB=F1LQT1	Adenylate cyclase 7	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MACMU|Ensembl=ENSMMUG00000007027|UniProtKB=F7F210	Alpha-cardiac actin	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00029	Huntington disease	P00790	beta-Tubulin	MOUSE|MGI=MGI=107848|UniProtKB=Q9D6F9	Tubulin beta-4A chain	TAS	12932731	PubMed	PTHR11588:SF253	TUBULIN BETA-4A CHAIN
P04393	Ras Pathway	P04552	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IDA	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	21071228	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	ISS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000010521|UniProtKB=F7DQK7	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	HUMAN|HGNC=7882|UniProtKB=Q04721	Neurogenic locus notch homolog protein 2	IDA	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	MONDO|Ensembl=ENSMODG00000018237|UniProtKB=F6PG65	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04495	TSC1	MOUSE|MGI=MGI=1929183|UniProtKB=Q9EP53	Hamartin	ISS	12167664	PubMed	PTHR15154:SF2	HAMARTIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ANOGA|EnsemblGenome=AGAP000651|UniProtKB=P84185	Actin-5C	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	DROME|FlyBase=FBgn0003944|UniProtKB=P83949	Homeotic protein ultrabithorax	IEP	12356903	PubMed	PTHR24326:SF144	HOMEOTIC PROTEIN ULTRABITHORAX
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00005	Angiogenesis	P00237	FRP	MOUSE|MGI=MGI=1196625|UniProtKB=O70421	Frizzled-1	ISS	11212302	PubMed	PTHR11309:SF81	FRIZZLED-1
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02738	De novo purine biosynthesis	P02899	GMP synthase	PYRAE|EnsemblGenome=PAE3369|UniProtKB=Q8ZT92	GMP synthase [glutamine-hydrolyzing]	ISS			PTHR11922:SF2	GMP SYNTHASE  GLUTAMINE-HYDROLYZING
P00047	PDGF signaling pathway	P01161	Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	DICPU|Gene=DICPUDRAFT_51488|UniProtKB=F1A411	Putative uncharacterized protein rasC	ISS	8290260	PubMed	PTHR24070:SF251	RAS-LIKE PROTEIN RASC
P06664	Gonadotropin-releasing hormone receptor pathway	P06786	ERK1/2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	RCA	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04398	p53 pathway feedback loops 2	P04665	AKT	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	ISS	12719720	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01407	Erk	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	XENTR|Xenbase=XB-GENE-957124|UniProtKB=F7BDN8	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00022	General transcription by RNA polymerase I	P00656	PTRF	BOVIN|Ensembl=ENSBTAG00000039684|UniProtKB=E1BNE7	Uncharacterized protein	ISS	603198	OMIM	PTHR15240:SF3	POLYMERASE I AND TRANSCRIPT RELEASE FACTOR
P00034	Integrin signalling pathway	P00940	Src	CANLF|Ensembl=ENSCAFG00000008755|UniProtKB=E2RSH8	Tyrosine-protein kinase	ISS	8054685	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00029	Huntington disease	P00777	CBP	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	IDA	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00018	EGF receptor signaling pathway	P00558	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00019	Endothelin signaling pathway	P00567	PKG	CAEEL|WormBase=WBGene00015650|UniProtKB=H2KYN2	Protein Kinase, cGMP-dependent	ISS			PTHR24353:SF91	PROTEIN KINASE, CGMP-DEPENDENT
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	MOUSE|MGI=MGI=1351342|UniProtKB=Q3UVX5	Metabotropic glutamate receptor 5	ISS	12488551	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	MONDO|Ensembl=ENSMODG00000007421|UniProtKB=F6XBV3	Uncharacterized protein	ISS	15226293	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00019	Endothelin signaling pathway	P00568	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IGI	3755548	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00010	B cell activation	P00381	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01143	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10755300	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00036	Interleukin signaling pathway	P00987	SRF	MONDO|Ensembl=ENSMODG00000018981|UniProtKB=F7FP88	Uncharacterized protein	ISS	15647354	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	ENTHI|Gene=EHI_112050|UniProtKB=C4M7H7	TATA-box-binding protein 2	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MOUSE|MGI=MGI=87939|UniProtKB=P25962	Beta-3 adrenergic receptor	IDA	12063255	PubMed	PTHR24248:SF3	BETA-3 ADRENERGIC RECEPTOR
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	BOVIN|Ensembl=ENSBTAG00000009269|UniProtKB=F1MCM2	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00047	PDGF signaling pathway	P01168	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00049	Parkinson disease	P01237	Complex I	BOVIN|Ensembl=ENSBTAG00000004871|UniProtKB=P04394	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	ISS	3100899	PubMed	PTHR10371:SF3	NADH DEHYDROGENASE  UBIQUINONE  FLAVOPROTEIN 2, MITOCHONDRIAL
P00029	Huntington disease	P00788	Calpain	MOUSE|MGI=MGI=88263|UniProtKB=O35350	Calpain-1 catalytic subunit	IDA	11675509	PubMed	PTHR10183:SF284	CALPAIN-1 CATALYTIC SUBUNIT
P00047	PDGF signaling pathway	P01169	Vav	MOUSE|MGI=MGI=1888518|UniProtKB=Q9R0C8	Guanine nucleotide exchange factor VAV3	ISS	14623913	PubMed	PTHR22826:SF97	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3
P00012	Cadherin signaling pathway	P00474	Wnt	CANLF|Ensembl=ENSCAFG00000009672|UniProtKB=E2RDT2	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00056	VEGF signaling pathway	P01417	Raf	MOUSE|MGI=MGI=88190|UniProtKB=P28028	Serine/threonine-protein kinase B-raf	ISS	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00059	p53 pathway	G01569	Maspin	HUMAN|HGNC=8949|UniProtKB=P36952	Serpin B5	TAS	10692390	PubMed	PTHR11461:SF55	SERPIN B5
P00034	Integrin signalling pathway	P00907	ERK	RAT|RGD=620966|UniProtKB=Q62925	Mitogen-activated protein kinase kinase kinase 1	IC			PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00036	Interleukin signaling pathway	P00965	ERK	MACMU|Ensembl=ENSMMUG00000008503|UniProtKB=F6TGJ6	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P02744	Fructose galactose metabolism	P02963	Ketohexokinase	MOUSE|MGI=MGI=1096353|UniProtKB=P97328	Ketohexokinase	ISS	9799106	PubMed	PTHR43085:SF1	KETOHEXOKINASE
P00006	Apoptosis signaling pathway	P00269	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00967	c-fos	BOVIN|Ensembl=ENSBTAG00000004322|UniProtKB=O77628	Proto-oncogene c-Fos	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P02753	Methionine biosynthesis	P03023	Homoserine succinyltransferase	BACSU|EnsemblGenome=BSU21910|UniProtKB=P54167	Homoserine O-succinyltransferase	ISS			PTHR20919:SF0	HOMOSERINE O-SUCCINYLTRANSFERASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CHICK|Ensembl=ENSGALG00000012894|UniProtKB=P30372	Muscarinic acetylcholine receptor M2	IDA	91373358	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	PANTR|Ensembl=ENSPTRG00000004701|UniProtKB=H2Q5G9	Low density lipoprotein receptor-related protein 6	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00020	FAS signaling pathway	P00615	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	IDA	12040174	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05917	Opioid proopiomelanocortin pathway	P06004	Mu or Delta receptor	MACMU|Ensembl=ENSMMUG00000009389|UniProtKB=F7HEV7	Uncharacterized protein	ISS	11259487	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00049	Parkinson disease	P01211	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	STRPU|EnsemblGenome=SPU_016007|UniProtKB=W4YJP3	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	RCA	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00590	IP3 R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	IDA	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05925	beta-ARR1	CANLF|Ensembl=ENSCAFG00000005415|UniProtKB=F1PQM2	Uncharacterized protein	ISS	11742073	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00054	Toll receptor signaling pathway	P01365	TAB1	CANLF|Ensembl=ENSCAFG00000001332|UniProtKB=F1PLP7	Uncharacterized protein	ISS	8638164	PubMed	PTHR13832:SF533	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1
P00012	Cadherin signaling pathway	P00470	F-actin	CANAL|CGD=CAL0064759|UniProtKB=Q5AKX0	Uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00025	Hedgehog signaling pathway	P00682	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01443	Phospholipase C	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	IDA	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	HALSA|EnsemblGenome=VNG_1414G|UniProtKB=Q9HPY5	Serine hydroxymethyltransferase	ISS			PTHR11680:SF21	SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	PANTR|Ensembl=ENSPTRG00000028511|UniProtKB=H2R570	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF81	FRIZZLED-1
P00053	T cell activation	P01304	Csk	RAT|RGD=1308800|UniProtKB=P32577	Tyrosine-protein kinase CSK	IDA	7687537	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	DICDI|dictyBase=DDB_G0272110|UniProtKB=P51136	Glycogen synthase kinase-3	TAS			PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00053	T cell activation	P01305	Calmodulin	TAKRU|Ensembl=ENSTRUG00000008685|UniProtKB=H2TXN3	Uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF326	CALMODULIN
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	BACSU|EnsemblGenome=BSU37150|UniProtKB=P13242	CTP synthase	ISS			PTHR11550:SF0	CTP SYNTHASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	DANRE|ZFIN=ZDB-GENE-050417-59|UniProtKB=Q15KE4	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	LEIMA|EnsemblGenome=LmjF.35.1010|UniProtKB=Q9NHE1	Casein kinase 1 isoform 2	IDA	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00048	PI3 kinase pathway	P01179	PKB	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00907	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	HUMAN|HGNC=4583|UniProtKB=Q16478	Glutamate receptor ionotropic, kainate 5	ISS	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00005	Angiogenesis	P00206	Wnt	MOUSE|MGI=MGI=98959|UniProtKB=P22726	Protein Wnt-5b	ISS	11266476	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00049	Parkinson disease	P01238	14-3-3	DANRE|ZFIN=ZDB-GENE-050306-44|UniProtKB=Q5CZQ1	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00632	Akt	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	ISS	12089061	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04455	beta-endorphin	XENTR|Xenbase=XB-GENE-483703|UniProtKB=Q5M8F2	Proopiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000020947|UniProtKB=F7CY46	Uncharacterized protein	ISS	12441358	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P05918	p38 MAPK pathway	P06032	MKK6	PANTR|Ensembl=ENSPTRG00000009588|UniProtKB=H2QZW5	Mitogen-activated protein kinase kinase 6	ISS	8622669	PubMed	PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	G04693	WIP-1	BOVIN|Ensembl=ENSBTAG00000009427|UniProtKB=E1BD03	Uncharacterized protein	ISS			PTHR13832:SF359	PROTEIN PHOSPHATASE 1D
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000023046|UniProtKB=F6V829	Uncharacterized protein	ISS	11431030	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00021	FGF signaling pathway	P00632	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IGI	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	CAEEL|WormBase=WBGene00007974|UniProtKB=Q93341	Putative dihydrofolate reductase	ISS			PTHR22778:SF16	DIHYDROFOLATE REDUCTASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	BOVIN|Ensembl=ENSBTAG00000039153|UniProtKB=F1MQE1	Ribosomal protein S6 kinase	ISS	9792677	PubMed	PTHR24351:SF41	RIBOSOMAL PROTEIN S6 KINASE ALPHA-4
P04393	Ras Pathway	P04547	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MACMU|Ensembl=ENSMMUG00000017431|UniProtKB=F7HPP3	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	ARATH|TAIR=AT3G03800|UniProtKB=Q9SRV7	Putative syntaxin-131	IC			PTHR19957:SF144	SYNTAXIN-132-RELATED
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04397	p53 pathway by glucose deprivation	P04636	S6K	PANTR|Ensembl=ENSPTRG00000009477|UniProtKB=H2QDK7	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P02723	Adenine and hypoxanthine salvage pathway	P02810	Adenine phosphoribosyl transferase	PSEAE|EnsemblGenome=PA1543|UniProtKB=Q04633	Adenine phosphoribosyltransferase	ISS			PTHR11776:SF0	ADENINE PHOSPHORIBOSYLTRANSFERASE-RELATED
P00034	Integrin signalling pathway	P00927	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	8649368	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00018	EGF receptor signaling pathway	P00559	MEK1-2	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00047	PDGF signaling pathway	P01160	IP3 receptor	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00964	p90RSK	PANTR|Ensembl=ENSPTRG00000000387|UniProtKB=H2PYE3	Ribosomal protein S6 kinase	ISS	12769834	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CANLF|Ensembl=ENSCAFG00000003333|UniProtKB=F1PWT6	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00053	T cell activation	P01311	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	XENTR|Xenbase=XB-GENE-487200|UniProtKB=Q28GC2	Catenin (Cadherin associated protein), beta 1, 88kDa	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00005	Angiogenesis	P00221	JNK1	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	HUMAN|HGNC=17376|UniProtKB=Q9UIJ7	GTP:AMP phosphotransferase AK3, mitochondrial	ISS			PTHR23359:SF68	GTP:AMP PHOSPHOTRANSFERASE AK3, MITOCHONDRIAL
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04380	Cortocotropin releasing factor receptor signaling pathway	G04671	proopiomelanocortin	DANRE|ZFIN=ZDB-GENE-041014-294|UniProtKB=Q5SPP4	Uncharacterized protein	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02746	Heme biosynthesis	P02979	porphobilinogen synthase	PHYPA|Gene=PHYPADRAFT_173375|UniProtKB=A9U2X5	Delta-aminolevulinic acid dehydratase	ISS			PTHR11458:SF0	DELTA-AMINOLEVULINIC ACID DEHYDRATASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	RCA	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=19300|UniProtKB=Q8N4C7	Syntaxin-19	IC	11067767	PubMed	PTHR19957:SF29	SYNTAXIN-19
P00047	PDGF signaling pathway	P01153	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05915	Opioid proenkephalin pathway	P05989	leu-Enkephalin	MOUSE|MGI=MGI=104629|UniProtKB=P22005	Proenkephalin-A	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00045	Notch signaling pathway	P01110	Presenilin	RAT|RGD=3425|UniProtKB=P97887	Presenilin-1	IEP	12736250	PubMed	PTHR10202:SF18	PRESENILIN-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00036	Interleukin signaling pathway	P00967	c-fos	BOVIN|Ensembl=ENSBTAG00000004322|UniProtKB=O77628	Proto-oncogene c-Fos	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P02747	Histidine biosynthesis	P02986	Phosphoribosyl ATP pyrophosphatase	RHOBA|EnsemblGenome=RB5601|UniProtKB=Q7URL1	Phosphoribosyl-ATP pyrophosphatase	ISS			PTHR42945:SF1	HISTIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN HISIE, CHLOROPLASTIC
P00011	Blood coagulation	P00448	vWF	PANTR|Ensembl=ENSPTRG00000004566|UniProtKB=H2Q597	Uncharacterized protein	ISS	11583304	PubMed	PTHR11339:SF361	VON WILLEBRAND FACTOR-RELATED
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MACMU|Ensembl=ENSMMUG00000001661|UniProtKB=F7GR69	Uncharacterized protein	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	TAS	10669416	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	BOVIN|Ensembl=ENSBTAG00000004775|UniProtKB=F1MBY1	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00053	T cell activation	P01332	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00029	Huntington disease	P00775	Rac	MONDO|Ensembl=ENSMODG00000000965|UniProtKB=F7ESZ6	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF13	RHO-RELATED GTP-BINDING PROTEIN RHOQ
P05731	GABA-B receptor II signaling	P05752	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01196	PDK1	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	IDA	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00029	Huntington disease	P00779	TBP	METAC|EnsemblGenome=MA_0179|UniProtKB=Q8TU94	TATA-box-binding protein 2	IPI	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00019	Endothelin signaling pathway	P00568	PKC	TAKRU|Ensembl=ENSTRUG00000016241|UniProtKB=H2UX35	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF305	PROTEIN KINASE C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	CHICK|Ensembl=ENSGALG00000000681|UniProtKB=E1C3P6	Uncharacterized protein	ISS	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=12778|UniProtKB=O14904	Protein Wnt-9a	IDA	8717036	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00021	FGF signaling pathway	P00629	PP2A	RAT|RGD=1305657|UniProtKB=A0A0G2JTA1	Protein Ppp2r5e	ISS	11007767	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00053	T cell activation	P01336	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00236	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DANRE|ZFIN=ZDB-GENE-030131-6503|UniProtKB=Q7ZUC5	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF297	PROTEIN KINASE C DELTA TYPE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00004	Alzheimer disease-presenilin pathway	P00114	actin	XENTR|GeneID=394982|UniProtKB=P20399	Actin, alpha cardiac muscle 2	ISS	11889126	PubMed	PTHR11937:SF263	ACTIN
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	DANRE|ZFIN=ZDB-GENE-030616-53|UniProtKB=Q71E60	AMPA receptor subunit GluR3B	ISS	12941441	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	XENTR|Xenbase=XB-GENE-5801166|UniProtKB=F6ZE26	Uncharacterized protein	ISS	1904317	PubMed	PTHR24070:SF382	RAS-RELATED PROTEIN RAP-1B
P00029	Huntington disease	P00788	Calpain	RAT|RGD=620085|UniProtKB=Q78EJ9	Calpain-8	IDA	11675509	PubMed	PTHR10183:SF374	CALPAIN-8
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	DICPU|Gene=DICPUDRAFT_91511|UniProtKB=F0ZDJ1	Serine/threonine-protein phosphatase	ISS	10452519	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	IDA	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	8838325	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DROME|FlyBase=FBgn0259680|UniProtKB=P83099	Putative protein kinase C delta type homolog	ISS	15572354	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00005	Angiogenesis	P00189	Fzd	MOUSE|MGI=MGI=108476|UniProtKB=Q61086	Frizzled-3	ISS	8717036	PubMed	PTHR11309:SF22	FRIZZLED-3
P00004	Alzheimer disease-presenilin pathway	P00139	E-cadherin transmembrane fragment	MACMU|Ensembl=ENSMMUG00000010393|UniProtKB=F7D992	Uncharacterized protein	ISS	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	TAKRU|Ensembl=ENSTRUG00000006611|UniProtKB=H2SV11	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	YEAST|SGD=S000005600|UniProtKB=P06785	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00021	FGF signaling pathway	P00643	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01145	c-fos	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P05918	p38 MAPK pathway	P06021	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04393	Ras Pathway	P04566	Stat 1/3	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	14984365	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00018	EGF receptor signaling pathway	P00563	Gab	HUMAN|HGNC=4066|UniProtKB=Q13480	GRB2-associated-binding protein 1	IGI	15356145	PubMed	PTHR12156:SF18	GRB2-ASSOCIATED-BINDING PROTEIN 1
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	DROME|FlyBase=FBgn0002413|UniProtKB=O76324	Discs overgrown protein kinase	IDA	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P04372	5-Hydroxytryptamine degredation	P04401	Monoamine Oxidase	BOVIN|Ensembl=ENSBTAG00000016206|UniProtKB=P21398	Amine oxidase [flavin-containing] A	ISS	90344230	PubMed	PTHR43563:SF3	AMINE OXIDASE  FLAVIN-CONTAINING  A
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	HUMAN|HGNC=7850|UniProtKB=P22392	Nucleoside diphosphate kinase B	ISS			PTHR11349:SF57	NUCLEOSIDE DIPHOSPHATE KINASE B
P00052	TGF-beta signaling pathway	P01286	TGFbeta	BOVIN|Gene=INHBB|UniProtKB=P42917	Inhibin beta B chain	TAS	11451570	PubMed	PTHR11848:SF29	INHIBIN BETA B CHAIN
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=19663|UniProtKB=Q9UBI6	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00034	Integrin signalling pathway	P00928	alpha actinin	BOVIN|Ensembl=ENSBTAG00000018255|UniProtKB=Q3B7N2	Alpha-actinin-1	ISS	2116421	PubMed	PTHR43947:SF3	ALPHA-ACTININ-1
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00021	FGF signaling pathway	P00624	14-3-3	MONDO|Ensembl=ENSMODG00000013658|UniProtKB=F6TY10	Uncharacterized protein	ISS	91108808	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00049	Parkinson disease	P01238	14-3-3	YEAST|SGD=S000002506|UniProtKB=P34730	Protein BMH2	IDA	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00018	EGF receptor signaling pathway	P00547	PP2A	RAT|RGD=3380|UniProtKB=P63331	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	IGI	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MACMU|Ensembl=ENSMMUG00000001672|UniProtKB=F7G3M7	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF32	REGULATOR OF G-PROTEIN SIGNALING 13
P00012	Cadherin signaling pathway	P00470	F-actin	ORYSJ|EnsemblGenome=OS05G0106600|UniProtKB=Q65XH8	Os05g0106600 protein	IC	10974003	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	BOVIN|Gene=STAT3|UniProtKB=P61635	Signal transducer and activator of transcription 3	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	9514948	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00056	VEGF signaling pathway	P01422	eNOS	RAT|RGD=3186|UniProtKB=Q62600	Nitric oxide synthase, endothelial	ISS	9837777	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	ISS	94280860	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00018	EGF receptor signaling pathway	P00546	GAP	DROME|FlyBase=FBgn0004390|UniProtKB=P48423	GTPase-activating protein	IGI	92191280	PubMed	PTHR10194:SF126	GTPASE-ACTIVATING PROTEIN
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	CHICK|Ensembl=ENSGALG00000013760|UniProtKB=F1P1F9	Uncharacterized protein	ISS			PTHR10937:SF10	GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE  ISOMERIZING  2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02785	Valine biosynthesis	P03218	Dihydroxy isovalerate dehydratase	NEUCR|EnsemblGenome=EFNCRG00000007655|UniProtKB=Q7SBQ5	Dihydroxy-acid dehydratase	ISS			PTHR21000:SF13	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00190	RasGAP	ORNAN|Ensembl=ENSOANG00000014753|UniProtKB=F7EPN2	Uncharacterized protein (Fragment)	ISS	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	MOUSE|MGI=MGI=102897|UniProtKB=F6XJP7	Protein Pcsk6	IDA			PTHR42884:SF8	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 6
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-7595|UniProtKB=Q6PBR4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01425	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01435	SWI/SNF	XENTR|Xenbase=XB-GENE-493598|UniProtKB=Q6DFM1	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1	ISS	11532957	PubMed	PTHR10019:SF5	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY B MEMBER 1
P00047	PDGF signaling pathway	P01168	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01290	TAB	HUMAN|HGNC=18157|UniProtKB=Q15750	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1	IGI	10838074	PubMed	PTHR13832:SF533	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1
P00010	B cell activation	P00373	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IGI	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00012	Cadherin signaling pathway	P00474	Wnt	MACMU|Ensembl=ENSMMUG00000021725|UniProtKB=F7E738	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00011	Blood coagulation	P00429	PN2	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	ISS	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00012	Cadherin signaling pathway	P00470	F-actin	CANLF|Ensembl=ENSCAFG00000008756|UniProtKB=F2Z4N8	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00004	Alzheimer disease-presenilin pathway	P00170	Aph-1	CANLF|Ensembl=ENSCAFG00000011777|UniProtKB=E2R5H5	Anterior pharynx defective 1 homolog A	ISS	12471034	PubMed	PTHR12889:SF3	GAMMA-SECRETASE SUBUNIT APH-1A
P02746	Heme biosynthesis	P02972	Ferrochelatase	RAT|RGD=1307556|UniProtKB=D3ZBM3	Ferrochelatase	ISS			PTHR11108:SF1	FERROCHELATASE, MITOCHONDRIAL
P04395	Vasopressin synthesis	P04593	Glycopeptide	TAKRU|Ensembl=ENSTRUG00000015413|UniProtKB=H2UR30	Uncharacterized protein	IC			PTHR11681:SF13	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00775	Rac	XENTR|Xenbase=XB-GENE-967585|UniProtKB=Q28BZ0	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS			PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00010	B cell activation	P00398	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	91072385	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	RAT|RGD=1359694|UniProtKB=P62836	Ras-related protein Rap-1A	ISS	10476970	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CAEEL|WormBase=WBGene00006932|UniProtKB=Q9TXI7	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	11927551	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	NAS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00470	F-actin	DANRE|ZFIN=ZDB-GENE-030131-1229|UniProtKB=Q6DHS1	Actin, alpha 2, smooth muscle, aorta	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ARATH|TAIR=AT2G39990|UniProtKB=O04202	Eukaryotic translation initiation factor 3 subunit F	ISS			PTHR10540:SF6	EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F
P00018	EGF receptor signaling pathway	P00545	JNK1-3	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00059	p53 pathway	P04626	GADD45	PANTR|Ensembl=ENSPTRG00000000842|UniProtKB=H2R902	Growth arrest and DNA-damage-inducible, alpha	ISS	10097101	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P04393	Ras Pathway	P04547	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00029	Huntington disease	P00780	Microtubule	PRIPA|Gene=PPA02893|UniProtKB=H3DZP2	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF120	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01199	Galpha	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IC	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00048	PI3 kinase pathway	P01179	PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IDA	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00048	PI3 kinase pathway	P01181	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	IDA	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CANLF|Ensembl=ENSCAFG00000009203|UniProtKB=F1PVZ1	Muscarinic acetylcholine receptor	ISS	8100450	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	HUMAN|HGNC=9508|UniProtKB=P49768	Presenilin-1	TAS	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P00059	p53 pathway	G04694	p110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00477	GSK3beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00005	Angiogenesis	P00223	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	HUMAN|HGNC=5465|UniProtKB=P08069	Insulin-like growth factor 1 receptor	TAS	11182407	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00057	Wnt signaling pathway	P01444	Wnt	CIOIN|Ensembl=ENSCING00000000407|UniProtKB=Q9U6V0	Protein Wnt	IDA	11266476	PubMed	PTHR12027:SF77	PROTEIN WNT-5
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00053	T cell activation	P01333	cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	CHICK|Ensembl=ENSGALG00000028896|UniProtKB=R4GMK5	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF728	MYOSIN HEAVY CHAIN, SKELETAL MUSCLE, ADULT
P00021	FGF signaling pathway	P00645	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12874273	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	CAEEL|WormBase=WBGene00001606|UniProtKB=Q9XVU2	GLutamiNe synthetase (Glutamate-ammonia ligase)	ISS			PTHR20852:SF39	GLUTAMINE SYNTHETASE  GLUTAMATE-AMMONIA LIGASE
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	MACMU|Ensembl=ENSMMUG00000008696|UniProtKB=F7E5W7	Uncharacterized protein	ISS			PTHR15138:SF18	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01455	Smad4	MONDO|Ensembl=ENSMODG00000000500|UniProtKB=F6TU68	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P02787	Vitamin B6 metabolism	P03236	Pyridoxamine phosphate oxidase	BOVIN|Ensembl=ENSBTAG00000012259|UniProtKB=Q5E9K3	Pyridoxine-5'-phosphate oxidase	ISS	9601034	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	BOVIN|Ensembl=ENSBTAG00000014447|UniProtKB=A4IFF4	Ribosomal protein S6 kinase	ISS	12769834	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	XENTR|Xenbase=XB-GENE-976753|UniProtKB=Q0VFR6	Syntaxin 1A (Brain)	ISS	1321498	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00022	General transcription by RNA polymerase I	P00649	TAF-IC	SCHPO|PomBase=SPCC1259.06|UniProtKB=O94706	Transcription initiation factor TFIID subunit 8	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00047	PDGF signaling pathway	P01164	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	9094314	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00053	T cell activation	P01318	PKC-theta	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00005	Angiogenesis	P00223	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS			PTHR24356:SF310	SUBFAMILY NOT NAMED
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00019	Endothelin signaling pathway	P00590	IP3 R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	CAEEL|WormBase=WBGene00000201|UniProtKB=Q9U1R7	ARp2/3 compleX component	ISS	12963527	gi	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00013	Cell cycle	P00483	Cyclin E	CHICK|Gene=CCNE1|UniProtKB=P49707	G1/S-specific cyclin-E1	NAS	1705768	gi	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P04393	Ras Pathway	P04579	Shc	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	IDA	7680960	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P05730	Endogenous cannabinoid signaling	P05751	Galpha	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02775	Salvage pyrimidine ribonucleotides	P03156	CDP kinase	CAEBR|Gene=CBG03314|UniProtKB=A8WUR5	Uridine kinase	ISS			PTHR10285:SF123	URIDINE KINASE
P00006	Apoptosis signaling pathway	P00272	ASK1	PANTR|Ensembl=ENSPTRG00000024326|UniProtKB=H2R231	Uncharacterized protein	ISS	11730323	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00057	Wnt signaling pathway	P01472	Histone deacetylase	CHICK|Gene=HDAC2|UniProtKB=P56519	Histone deacetylase 2	IDA	10485845	PubMed	PTHR10625:SF171	HISTONE DEACETYLASE 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00021	FGF signaling pathway	P00629	PP2A	XENTR|Xenbase=XB-GENE-990846|UniProtKB=F6QT86	Uncharacterized protein (Fragment)	ISS	11994459	PubMed	PTHR10648:SF2	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 65 KDA REGULATORY SUBUNIT A ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04665	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01187	IR	PANTR|Ensembl=ENSPTRG00000010386|UniProtKB=H2QF61	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=1754|UniProtKB=P55291	Cadherin-15	IDA	8120095	PubMed	PTHR24027:SF300	CADHERIN-15
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00025	Hedgehog signaling pathway	P00682	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00928	alpha actinin	PANTR|Ensembl=ENSPTRG00000002144|UniProtKB=H2Q1E4	Uncharacterized protein	ISS	2116421	PubMed	PTHR43947:SF4	ALPHA-ACTININ-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IDA	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	P01465	Ggamma	MOUSE|MGI=MGI=1336171|UniProtKB=Q9DAS9	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IDA	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	PANTR|Ensembl=ENSPTRG00000010931|UniProtKB=H2R650	Uncharacterized protein	ISS	8930069	PubMed	PTHR13715:SF15	RYANODINE RECEPTOR 1
P02778	Sulfate assimilation	P03164	Adenylylsulfate kinase	SCHPO|PomBase=SPAC1782.11|UniProtKB=Q9P7G9	Adenylyl-sulfate kinase	ISS			PTHR11055:SF1	PAPS SYNTHETASE, ISOFORM D
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00004	Alzheimer disease-presenilin pathway	P00148	Erb-B4 N-terminal fragment	MOUSE|MGI=MGI=104771|UniProtKB=Q61527	Receptor tyrosine-protein kinase erbB-4	ISS	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00021	FGF signaling pathway	P00627	ERK1-2	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	RCA	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	CANLF|Ensembl=ENSCAFG00000009282|UniProtKB=E2RLD6	Uncharacterized protein	ISS	123810	OMIM	PTHR22952:SF24	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1203729|UniProtKB=Q61194	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00054	Toll receptor signaling pathway	P01346	TLR	MOUSE|MGI=MGI=1341295|UniProtKB=Q9EPQ1	Toll-like receptor 1	ISS			PTHR24365:SF261	TOLL-LIKE RECEPTOR 1
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	HUMAN|HGNC=9751|UniProtKB=P47897	Glutamine--tRNA ligase	ISS			PTHR43097:SF1	GLUTAMINE--TRNA LIGASE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DROME|FlyBase=FBgn0000044|UniProtKB=P53501	Actin-57B	IC	14684598	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P04398	p53 pathway feedback loops 2	P04665	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-2555|UniProtKB=F8W3G9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00049	Parkinson disease	P01227	20S proteasome	CHICK|Ensembl=ENSGALG00000012039|UniProtKB=Q5ZLI2	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF10	PROTEASOME SUBUNIT ALPHA TYPE-3
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01160	IP3 receptor	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	IC	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00053	T cell activation	P01318	PKC-theta	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00047	PDGF signaling pathway	P01152	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	8262392	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_56698|UniProtKB=C3XYC3	Putative uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00049	Parkinson disease	P01208	Hsp70	BOVIN|Ensembl=ENSBTAG00000013162|UniProtKB=P19120	Heat shock cognate 71 kDa protein	IDA	12150907	PubMed	PTHR19375:SF239	HEAT SHOCK COGNATE 71 KDA PROTEIN
P00053	T cell activation	P01324	rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04384	Gamma-aminobutyric acid synthesis	P04480	GABA aminotransferase	RAT|RGD=620948|UniProtKB=P50554	4-aminobutyrate aminotransferase, mitochondrial	ISS	8133261	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	GIAIC|EnsemblGenome=GL50803_91056|UniProtKB=A8B1V5	Aspartate aminotransferase	ISS			PTHR11879:SF10	ASPARTATE AMINOTRANSFERASE
P00035	Interferon-gamma signaling pathway	P00956	SOCS	PANTR|Ensembl=ENSPTRG00000040283|UniProtKB=H2RII6	Suppressor of cytokine signaling 5	ISS	15032587	PubMed	PTHR44282:SF3	SUPPRESSOR OF CYTOKINE SIGNALING 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	CANLF|Ensembl=ENSCAFG00000010107|UniProtKB=E2RA74	Serine/threonine-protein kinase receptor	ISS	9395284	PubMed	PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04393	Ras Pathway	P04570	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01408	Akt/PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00819	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00581	Guanylate cyclase	HUMAN|HGNC=4687|UniProtKB=Q02153	Guanylate cyclase soluble subunit beta-1	RCA			PTHR11920:SF318	GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	PANTR|Ensembl=ENSPTRG00000005122|UniProtKB=H2Q6A6	Uncharacterized protein	ISS	11907044	PubMed	PTHR44025:SF2	PROLOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P02755	Methylmalonyl pathway	P03033	Propionyl-CoA carboxylase	IXOSC|EnsemblGenome=ISCW020770|UniProtKB=B7PXQ1	Propionyl-CoA carboxylase, putative (Fragment)	ISS			PTHR43842:SF1	SUBFAMILY NOT NAMED
P00010	B cell activation	P00385	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04395	Vasopressin synthesis	P04597	Signal Peptide	MACMU|Ensembl=ENSMMUG00000010678|UniProtKB=F7AXI7	Uncharacterized protein	ISS	1706187	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	MACMU|Ensembl=ENSMMUG00000018255|UniProtKB=F7DZJ9	Nuclear factor of activated T-cells 5 isoform c	ISS			PTHR12533:SF10	NUCLEAR FACTOR OF ACTIVATED T-CELLS 5
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	PANTR|Ensembl=ENSPTRG00000023608|UniProtKB=H2QZZ2	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	PANTR|Ensembl=ENSPTRG00000001787|UniProtKB=H2Q0T0	Phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P01482	ARF	PANTR|Ensembl=ENSPTRG00000010477|UniProtKB=H2QFC1	Uncharacterized protein	ISS			PTHR24148:SF47	CYCLIN-DEPENDENT KINASE 4 INHIBITOR B-RELATED
P06664	Gonadotropin-releasing hormone receptor pathway	P06798	PKCe/theta	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	RCA	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00059	p53 pathway	G04702	p53	CANLF|Gene=TP53|UniProtKB=Q29537	Cellular tumor antigen p53	TAS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	IDA	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00922	Collagen	MONDO|Ensembl=ENSMODG00000011359|UniProtKB=F6SPW3	Uncharacterized protein	ISS	10778855	PubMed	PTHR24023:SF539	COLLAGEN ALPHA-2 V  CHAIN
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05918	p38 MAPK pathway	P06044	GADD45	PANTR|Ensembl=ENSPTRG00000000842|UniProtKB=H2R902	Growth arrest and DNA-damage-inducible, alpha	ISS	9827804	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	CHICK|Gene=CCND1|UniProtKB=P55169	G1/S-specific cyclin-D1	IEP	12356903	PubMed	PTHR10177:SF67	G1/S-SPECIFIC CYCLIN-D1
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MOUSE|MGI=MGI=108476|UniProtKB=Q61086	Frizzled-3	TAS	8717036	PubMed	PTHR11309:SF22	FRIZZLED-3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=2685045|UniProtKB=E9QAN8	Protein Pik3c2b	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00029	Huntington disease	P00807	Actin	CHICK|Gene=ACTA2|UniProtKB=P08023	Actin, aortic smooth muscle	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IC	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DICPU|Gene=DICPUDRAFT_92985|UniProtKB=F1A084	Putative uncharacterized protein rac1A	ISS	8649368	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00029	Huntington disease	P00788	Calpain	BOVIN|Ensembl=ENSBTAG00000014872|UniProtKB=P13135	Calpain small subunit 1	ISS	11675509	PubMed	PTHR44408:SF3	CALPAIN SMALL SUBUNIT 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	MACMU|Ensembl=ENSMMUG00000010707|UniProtKB=F7G8G5	Signal transducer and activator of transcription	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P02775	Salvage pyrimidine ribonucleotides	P03149	Cytidine kinase	BOVIN|Ensembl=ENSBTAG00000044150|UniProtKB=E1BMA5	Uridine kinase	ISS			PTHR10285:SF70	URIDINE-CYTIDINE KINASE 2
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00561	STAT	MONDO|Ensembl=ENSMODG00000014816|UniProtKB=F7CHH2	Signal transducer and activator of transcription	ISS	10835485	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P05913	Enkephalin release	P05977	G-Protein (s)	NEUCR|EnsemblGenome=EFNCRG00000000159|UniProtKB=F5HH30	Guanine nucleotide-binding protein beta subunit	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	DROME|FlyBase=FBgn0050345|UniProtKB=Q1EC10	IP12271p	ISS			PTHR23507:SF1	GH23453P-RELATED
P04393	Ras Pathway	P04555	PDK	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	IDA	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00053	T cell activation	P01332	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02728	Arginine biosynthesis	P02842	N-acetylornithine aminotransferase	NEUCR|EnsemblGenome=EFNCRG00000006536|UniProtKB=Q9P3I3	Acetylornithine aminotransferase, mitochondrial	ISS	10074354	PubMed	PTHR11986:SF79	ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL
P05913	Enkephalin release	P05975	GPCR (s)	BOVIN|Gene=OPRM1|UniProtKB=P79350	Mu-type opioid receptor	ISS	12093103	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00057	Wnt signaling pathway	P01437	TCF	XENTR|Xenbase=XB-GENE-1031985|UniProtKB=Q6GL68	Transcription factor 7-like 1	ISS	9118222	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P06959	CCKR signaling map	P07054	PKCepsilon	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	RCA	15117677	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=1309999|UniProtKB=Q922R0	cAMP-dependent protein kinase catalytic subunit PRKX	IC	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00036	Interleukin signaling pathway	P00973	PKB	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00560	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02780	Thiamin metabolism	P03180	Nucleoside triphosphatase	PYRAE|EnsemblGenome=PAE2365|UniProtKB=Q8ZVB5	Non-canonical purine NTP pyrophosphatase	IEA	11792869	PubMed	PTHR11067:SF9	INOSINE TRIPHOSPHATE PYROPHOSPHATASE
P00049	Parkinson disease	P01241	TH	MACMU|Ensembl=ENSMMUG00000003912|UniProtKB=F6ZV38	Uncharacterized protein	ISS	12814656	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	MOUSE|MGI=MGI=97356|UniProtKB=Q01768	Nucleoside diphosphate kinase B	ISS			PTHR11349:SF57	NUCLEOSIDE DIPHOSPHATE KINASE B
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DICDI|dictyBase=DDB_G0279413|UniProtKB=P05987	cAMP-dependent protein kinase regulatory subunit	IC	176910	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00045	Notch signaling pathway	P01114	Ntm	PANTR|Ensembl=ENSPTRG00000010617|UniProtKB=H2QFL8	Notch 3	ISS	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00021	FGF signaling pathway	P00645	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	MACMU|Ensembl=ENSMMUG00000012895|UniProtKB=F6TMV9	Pyrroline-5-carboxylate reductase	ISS			PTHR11645:SF6	PYRROLINE-5-CARBOXYLATE REDUCTASE 1, MITOCHONDRIAL
P00029	Huntington disease	P00788	Calpain	DANRE|ZFIN=ZDB-GENE-040426-2814|UniProtKB=F1QI24	Uncharacterized protein	IDA	11675509	PubMed	PTHR10183:SF284	CALPAIN-1 CATALYTIC SUBUNIT
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IC	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00036	Interleukin signaling pathway	P00968	Ikk	MOUSE|MGI=MGI=1338071|UniProtKB=O88351	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	MACMU|Ensembl=ENSMMUG00000004450|UniProtKB=F7GN04	S-adenosylmethionine synthase	ISS			PTHR11964:SF12	S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000008719|UniProtKB=F1MZX0	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00006	Apoptosis signaling pathway	P00310	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000009626|UniProtKB=F6ZYQ0	Phosphoinositide phospholipase C	ISS			PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00019	Endothelin signaling pathway	P00566	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	11790551	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00029	Huntington disease	P00780	Microtubule	XENTR|Xenbase=XB-GENE-482185|UniProtKB=Q6GLE7	Tubulin beta chain	ISS	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00034	Integrin signalling pathway	P00942	Fyn	XENTR|Xenbase=XB-GENE-6053489|UniProtKB=F6S8L5	Tyrosine-protein kinase	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	IC	14744463	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	XENTR|Xenbase=XB-GENE-1005779|UniProtKB=F7E3I6	Uncharacterized protein	ISS	11248120	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00036	Interleukin signaling pathway	P00990	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04451	CRHR1	PANTR|Ensembl=ENSPTRG00000009311|UniProtKB=H2RDZ7	Uncharacterized protein	ISS	11145609	PubMed	PTHR12011:SF175	CORTICOTROPIN-RELEASING FACTOR RECEPTOR 1
P00030	Hypoxia response via HIF activation	P00814	P300	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	MOUSE|MGI=MGI=97577|UniProtKB=Q8BWJ3	Phosphorylase b kinase regulatory subunit alpha, liver isoform	ISS	10487978	PubMed	PTHR10749:SF5	PHOSPHORYLASE B KINASE REGULATORY SUBUNIT ALPHA, LIVER ISOFORM
P00029	Huntington disease	P00787	MAPKK4	CHICK|Ensembl=ENSGALG00000001001|UniProtKB=F1P3T1	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00057	Wnt signaling pathway	P01443	Phospholipase C	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00047	PDGF signaling pathway	P01150	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00036	Interleukin signaling pathway	P00965	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00009	Axon guidance mediated by netrin	P00363	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00570	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	ISS	10477300	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00019	Endothelin signaling pathway	P00568	PKC	YEAST|SGD=S000000201|UniProtKB=P24583	Protein kinase C-like 1	ISS	125549	gi	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00049	Parkinson disease	P01211	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04397	p53 pathway by glucose deprivation	P04640	p53	HUMAN|HGNC=15979|UniProtKB=Q9H3D4	Tumor protein 63	TAS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	BOVIN|Ensembl=ENSBTAG00000005714|UniProtKB=Q3ZC07	Actin, alpha cardiac muscle 1	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00056	VEGF signaling pathway	P01413	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04633	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00029	Huntington disease	P00779	TBP	ENTHI|Gene=EHI_020610|UniProtKB=P52653	TATA-box-binding protein 1	IPI	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00046	Oxidative stress response	P01126	ATF2	MONDO|Ensembl=ENSMODG00000009514|UniProtKB=F7EVK3	Uncharacterized protein	ISS	9819389	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00021	FGF signaling pathway	P00643	Raf-1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02770	Pyridoxal phosphate salvage pathway	P03123	Pyridoxine-5-phosphate oxidase	MACMU|Ensembl=ENSMMUG00000003325|UniProtKB=F7EHD9	Pyridoxine-5'-phosphate oxidase	ISS	9601034	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00057	Wnt signaling pathway	P01456	beta-arrestin	ANOGA|EnsemblGenome=AGAP010134|UniProtKB=Q95NF3	AGAP010134-PA	IC	11742073	PubMed	PTHR11792:SF16	PHOSRESTIN-2
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06807	gnai	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	RCA	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00010	B cell activation	P00397	IKK	PANTR|Ensembl=ENSPTRG00000033948|UniProtKB=H2RBD4	Conserved helix-loop-helix ubiquitous kinase	ISS	14499113	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04651	Ras	CAEEL|WormBase=WBGene00002335|UniProtKB=P22981	Ras protein let-60	IDA	12024031	PubMed	PTHR24070:SF385	GTPASE HRAS
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	MACMU|Ensembl=ENSMMUG00000023046|UniProtKB=F6V829	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	IC	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00034	Integrin signalling pathway	P00947	Laminin	DROME|FlyBase=FBgn0267348|UniProtKB=P15215	Laminin subunit gamma-1	IPI	2538453	PubMed	PTHR10574:SF79	LAMININ SUBUNIT GAMMA-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00012	Cadherin signaling pathway	P00474	Wnt	RAT|RGD=628850|UniProtKB=B1WBR9	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000023202|UniProtKB=F7EU36	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_56687|UniProtKB=C3YC50	Putative uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P06959	CCKR signaling map	P07032	MEF2	HUMAN|HGNC=6997|UniProtKB=Q14814	Myocyte-specific enhancer factor 2D	RCA	16376520	PubMed	PTHR11945:SF23	MYOCYTE-SPECIFIC ENHANCER FACTOR 2D
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00011	Blood coagulation	P00416	Prothrombin	CHICK|Ensembl=ENSGALG00000008332|UniProtKB=F1NXV6	Prothrombin	ISS	+176930	OMIM	PTHR24254:SF10	PROTHROMBIN
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	88241036	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	MACMU|Ensembl=ENSMMUG00000020322|UniProtKB=F6WHL1	Fructose-bisphosphate aldolase	ISS	3105602	PubMed	PTHR11627:SF3	FRUCTOSE-BISPHOSPHATE ALDOLASE C
P00046	Oxidative stress response	P01129	JNK1/2	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00034	Integrin signalling pathway	P00922	Collagen	HUMAN|HGNC=2212|UniProtKB=P12110	Collagen alpha-2(VI) chain	IDA	10778855	PubMed	PTHR44172:SF1	COLLAGEN ALPHA-2 VI  CHAIN
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00898	FKHR	HUMAN|HGNC=3821|UniProtKB=O43524	Forkhead box protein O3	ISS	12884295	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00029	Huntington disease	P00767	Pro-caspase 8	PANTR|Ensembl=ENSPTRG00000012801|UniProtKB=H2QJ86	Caspase 8, apoptosis-related cysteine peptidase	ISS	8681376	PubMed	PTHR10454:SF162	CASPASE-8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PLAF7|EnsemblGenome=PF14_0124|UniProtKB=Q8ILW9	Actin-2	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00047	PDGF signaling pathway	P01154	Ras	CAEBR|Gene=CBG06092|UniProtKB=A8X0X5	Protein CBR-LET-60	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	SCHMA|EnsemblGenome=Smp_020170|UniProtKB=G4V8E3	Voltage-dependent calcium channel (Fragment)	ISS	8386525	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P00007	Axon guidance mediated by semaphorins	P00340	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	MACMU|Ensembl=ENSMMUG00000006702|UniProtKB=F7HJS7	Serine/threonine-protein kinase receptor	ISS	9395284	PubMed	PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	HUMAN|HGNC=9509|UniProtKB=P49810	Presenilin-2	IDA	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	RCA	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00019	Endothelin signaling pathway	P00589	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	DANRE|ZFIN=ZDB-GENE-010125-1|UniProtKB=B8JHS2	Uncharacterized protein	IDA	11259498	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	BOVIN|Ensembl=ENSBTAG00000035697|UniProtKB=Q28024	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	HUMAN|HGNC=8569|UniProtKB=P29122	Proprotein convertase subtilisin/kexin type 6	IDA			PTHR42884:SF8	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 6
P04398	p53 pathway feedback loops 2	P04665	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05754	Ggamma	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04393	Ras Pathway	P04545	Sec5	PANTR|Ensembl=ENSPTRG00000017657|UniProtKB=H2QS72	Exocyst complex component 2	ISS			PTHR13043:SF1	EXOCYST COMPLEX COMPONENT 2
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04397	p53 pathway by glucose deprivation	P04641	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00056	VEGF signaling pathway	P01417	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00960	PTP	MONDO|Ensembl=ENSMODG00000003120|UniProtKB=F6WVD2	Tyrosine-protein phosphatase non-receptor type	ISS	8096088	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	CANLF|Ensembl=ENSCAFG00000032451|UniProtKB=J9NTI3	Actin-related protein 2/3 complex subunit 5	ISS			PTHR12644:SF2	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5-LIKE PROTEIN
P00012	Cadherin signaling pathway	P00470	F-actin	CHICK|Ensembl=ENSGALG00000009844|UniProtKB=P68034	Actin, alpha cardiac muscle 1	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	MYCTU|EnsemblGenome=Rv0570|UniProtKB=P9WH77	Vitamin B12-dependent ribonucleoside-diphosphate reductase	ISS			PTHR43371:SF1	SUBFAMILY NOT NAMED
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	HUMAN|HGNC=6017|UniProtKB=Q01344	Interleukin-5 receptor subunit alpha	IPI	1732409	PubMed	PTHR23036:SF17	INTERLEUKIN-5 RECEPTOR SUBUNIT ALPHA
P00020	FAS signaling pathway	P00620	CytochromeC	BRADU|EnsemblGenome=BAC47751|UniProtKB=P51131	Cytochrome b/c1	IGI	15163634	PubMed	PTHR19271:SF5	CYTOCHROME B
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00008	Axon guidance mediated by Slit/Robo	P00344	Netrin	PANTR|Ensembl=ENSPTRG00000001023|UniProtKB=H2R8U5	Uncharacterized protein	ISS			PTHR10574:SF28	NETRIN-G1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00036	Interleukin signaling pathway	P00985	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	15531926	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00996	STAT	RAT|RGD=3774|UniProtKB=P52632	Signal transducer and activator of transcription 5B	IC	8584036	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CAEBR|Gene=CBG05858|UniProtKB=A8X1H0	Protein CBR-EGL-19 (Fragment)	ISS	15621031	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IGI	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=1310389|UniProtKB=D3ZTF6	Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Predicted), isoform CRA_a	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02918	dUTP pyrophosphatase	CHLTR|EnsemblGenome=CT_292|UniProtKB=O84294	Deoxyuridine 5'-triphosphate nucleotidohydrolase	ISS			PTHR11241:SF0	BCDNA.LD08534
P00036	Interleukin signaling pathway	P00973	PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	RAT|RGD=619729|UniProtKB=O88204	Low-density lipoprotein receptor-related protein 3	IDA	11907044	PubMed	PTHR44062:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 3
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	RCA	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	PANTR|Ensembl=ENSPTRG00000006504|UniProtKB=H2R1H2	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF27	REGULATOR OF G-PROTEIN SIGNALING 6
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DROME|FlyBase=FBgn0000047|UniProtKB=P83967	Actin, indirect flight muscle	IDA	10974003	PubMed	PTHR11937:SF368	ACTIN, INDIRECT FLIGHT MUSCLE
P00048	PI3 kinase pathway	P01188	Gbetagamma	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00890	ELK	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	11279280	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00023	General transcription regulation	P00660	RNA Polymerase II	SCHPO|PomBase=SPAC23C4.15|UniProtKB=Q09191	DNA-directed RNA polymerases I, II, and III subunit RPABC1	ISS	11313498	PubMed	PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P00005	Angiogenesis	P00201	FVIIa	HUMAN|HGNC=3544|UniProtKB=P08709	Coagulation factor VII	IDA	10518503	gi	PTHR44064:SF1	COAGULATION FACTOR VII
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00045	Notch signaling pathway	P01114	Ntm	MOUSE|MGI=MGI=107471|UniProtKB=P31695	Neurogenic locus notch homolog protein 4	ISS	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	BOVIN|Ensembl=ENSBTAG00000008059|UniProtKB=P41984	Muscarinic acetylcholine receptor M3	IDA	12181435	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	HUMAN|HGNC=4586|UniProtKB=Q13224	Glutamate receptor ionotropic, NMDA 2B	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00006	Apoptosis signaling pathway	P00310	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000012314|UniProtKB=F7DGM2	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF81	CADHERIN-4
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	MOUSE|MGI=MGI=95792|UniProtKB=P05202	Aspartate aminotransferase, mitochondrial	ISS			PTHR11879:SF32	ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL
P00056	VEGF signaling pathway	P01425	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	PANTR|Ensembl=ENSPTRG00000006216|UniProtKB=H2Q832	Adenylate cyclase 4	ISS	9870949	PubMed	PTHR11920:SF286	ADENYLATE CYCLASE TYPE 4
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	TAKRU|Ensembl=ENSTRUG00000008289|UniProtKB=H2T7U8	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF129	CDC42L PROTEIN
P00034	Integrin signalling pathway	P00922	Collagen	RAT|RGD=1307148|UniProtKB=F1MA59	Protein Col4a1	ISS	10778855	PubMed	PTHR24023:SF854	COLLAGEN ALPHA-1 IV  CHAIN
P00034	Integrin signalling pathway	P00923	Arf1	XENTR|Xenbase=XB-GENE-950251|UniProtKB=Q6NT85	ADP-ribosylation factor 1	ISS	12932731	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00057	Wnt signaling pathway	P01465	Ggamma	TAKRU|Ensembl=ENSTRUG00000007253|UniProtKB=H2SZQ1	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	ORNAN|Ensembl=ENSOANG00000002406|UniProtKB=F7BAS2	Uncharacterized protein	ISS	11259591	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	DROME|FlyBase=FBgn0024920|UniProtKB=O76511	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	ARATH|TAIR=AT1G61290|UniProtKB=O64791	Syntaxin-124	IC			PTHR19957:SF80	SYNTAXIN-124-RELATED
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CAEBR|Gene=CBG01814|UniProtKB=A8WQR5	Protein CBR-LEV-1	ISS	22213672	PubMed	PTHR18945:SF747	ACETYLCHOLINE RECEPTOR SUBUNIT BETA-TYPE LEV-1
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	XENTR|Xenbase=XB-GENE-1010483|UniProtKB=F7AF72	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00021	FGF signaling pathway	P00629	PP2A	MACMU|Ensembl=ENSMMUG00000014001|UniProtKB=F6RRH0	Uncharacterized protein	ISS			PTHR10648:SF9	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 65 KDA REGULATORY SUBUNIT A BETA ISOFORM
P00057	Wnt signaling pathway	P01438	PP2A	MOUSE|MGI=MGI=1349473|UniProtKB=Q61151	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	ISS	11007767	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=1351343|UniProtKB=Q5NCH9	Metabotropic glutamate receptor 6	ISS	11431030	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00035	Interferon-gamma signaling pathway	P00960	PTP	DANRE|ZFIN=ZDB-GENE-030131-5911|UniProtKB=F1QZU5	Tyrosine-protein phosphatase non-receptor type	ISS	1382983	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00048	PI3 kinase pathway	P01199	Galpha	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02781	Threonine biosynthesis	P03189	Aspartate kinase	BACSU|EnsemblGenome=BSU28470|UniProtKB=P08495	Aspartokinase 2	ISS			PTHR21499:SF3	ASPARTOKINASE
P00047	PDGF signaling pathway	P01154	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00034	Integrin signalling pathway	P00948	Rho	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	IGI	10556059	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00047	PDGF signaling pathway	P01162	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00507	Rho	PANTR|Ensembl=ENSPTRG00000001112|UniProtKB=H2PZP2	Ras homolog gene family, member C	ISS	14871999	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00020	FAS signaling pathway	P00601	c-Jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	3136397	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00034	Integrin signalling pathway	P00937	Vinculin	HUMAN|HGNC=12665|UniProtKB=P18206	Vinculin	IPI	14702644	PubMed	PTHR18914:SF1	VINCULIN
P02743	Formyltetrahydroformate biosynthesis	P02953	Cobalamin dependent homocysteine transmethylase	RAT|RGD=621283|UniProtKB=Q9Z2Q4	Methionine synthase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	MOUSE|MGI=MGI=1351660|UniProtKB=Q9JMK2	Casein kinase I isoform epsilon	IDA	11865049	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00012	Cadherin signaling pathway	P00474	Wnt	ORNAN|Gene=WNT2|UniProtKB=Q07DZ8	Protein Wnt-2	ISS	8717036	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P02754	Methylcitrate cycle	P03028	Aconitase	DROME|FlyBase=FBgn0024957|UniProtKB=Q9VGZ3	Aconitate hydratase	ISS			PTHR11670:SF1	ACONITATE HYDRATASE
P00056	VEGF signaling pathway	P01413	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01172	c-Myc	XENTR|Xenbase=XB-GENE-6052814|UniProtKB=Q6P1T1	Uncharacterized protein	ISS	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000015092|UniProtKB=F6WUV0	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF96	CADHERIN-12
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	THEKO|EnsemblGenome=TK0132|UniProtKB=Q52366	TATA-box-binding protein	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12805548	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	15572354	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00629	PP2A	RAT|RGD=6503701|UniProtKB=F1MAA3	Protein LOC100909464	ISS	96161994	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00165	E-cadherin N-terminal fragment	PANTR|Ensembl=ENSPTRG00000008270|UniProtKB=H2QBE5	Uncharacterized protein	ISS	12834808	PubMed	PTHR24027:SF319	CADHERIN-1
P02787	Vitamin B6 metabolism	P03242	Threonine synthase	CRYNJ|EnsemblGenome=CNB01150|UniProtKB=Q5KMM7	Threonine synthase, putative	ISS	15077836	gi	PTHR42690:SF1	THREONINE SYNTHASE-LIKE 2
P04398	p53 pathway feedback loops 2	P04668	p53	HUMAN|HGNC=11998|UniProtKB=P04637	Cellular tumor antigen p53	TAS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IC	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00005	Angiogenesis	P00194	Paxillin	HUMAN|HGNC=11767|UniProtKB=O43294	Transforming growth factor beta-1-induced transcript 1 protein	ISS			PTHR24216:SF27	TRANSFORMING GROWTH FACTOR BETA-1-INDUCED TRANSCRIPT 1 PROTEIN
P00057	Wnt signaling pathway	P01452	NFAT	RAT|RGD=1308692|UniProtKB=A0A0G2JTY4	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 (Predicted), isoform CRA_b	ISS	12787506	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00006	Apoptosis signaling pathway	P00270	Bcl-2	RAT|RGD=2199|UniProtKB=P49950	Apoptosis regulator Bcl-2	IDA	11323415	PubMed	PTHR11256:SF11	APOPTOSIS REGULATOR BCL-2
P00037	Ionotropic glutamate receptor pathway	P01026	KA	XENTR|Xenbase=XB-GENE-957124|UniProtKB=F7BDN8	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00012	Cadherin signaling pathway	P00474	Wnt	MACMU|Ensembl=ENSMMUG00000020809|UniProtKB=F7H7P8	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	RAT|RGD=1308423|UniProtKB=D3ZY89	Protein Taf8	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P04396	Vitamin D metabolism and pathway	P04606	VDR	TAKRU|Ensembl=ENSTRUG00000011576|UniProtKB=H2TX49	Uncharacterized protein	ISS	11705326	PubMed	PTHR24082:SF38	VITAMIN D3 RECEPTOR
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	HUMAN|HGNC=7574|UniProtKB=Q9Y623	Myosin-4	ISS	89264452	PubMed	PTHR13140:SF681	MYOSIN-4
P00009	Axon guidance mediated by netrin	P00359	NFAT	BOVIN|Ensembl=ENSBTAG00000018270|UniProtKB=F1MGR9	Uncharacterized protein	ISS	12787506	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00018	EGF receptor signaling pathway	P00558	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IGI	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02785	Valine biosynthesis	P03215	Branched chain amino acid aminotransferase	MYCTU|EnsemblGenome=Rv2210c|UniProtKB=P9WQ75	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF44	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04569	Cdc42	TRIAD|EnsemblGenome=TriadG50431|UniProtKB=B3S037	Cdc42hs complexed with A peptide derived from P-21 activated kinase	ISS	15723050	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00006	Apoptosis signaling pathway	P00310	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IDA	12660731	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	CHICK|Ensembl=ENSGALG00000001334|UniProtKB=F1NLV4	Uncharacterized protein	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02723	Adenine and hypoxanthine salvage pathway	P02810	Adenine phosphoribosyl transferase	PSEAE|EnsemblGenome=PA5298|UniProtKB=Q9HTQ6	Xanthine phosphoribosyltransferase	ISS			PTHR43864:SF1	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	XENTR|Xenbase=XB-GENE-480347|UniProtKB=Q6P640	Actin, alpha cardiac muscle 1	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00006	Apoptosis signaling pathway	P00310	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	PANTR|Ensembl=ENSPTRG00000005793|UniProtKB=H2REV2	Uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF139	CASEIN KINASE I ISOFORM ALPHA-LIKE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04392	P53 pathway feedback loops 1	G04685	p73DeltaN	RAT|RGD=620863|UniProtKB=Q9JJP6	Tumor protein 63	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	HUMAN|HGNC=4574|UniProtKB=P48058	Glutamate receptor 4	ISS	12941441	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00056	VEGF signaling pathway	P01422	eNOS	CANLF|Gene=NOS3|UniProtKB=Q9TUX8	Nitric oxide synthase, endothelial	ISS	9837777	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P04393	Ras Pathway	P04555	PDK	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	15210700	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IDA	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05916	Opioid prodynorphin pathway	P05999	provasopressin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	CAEBR|Gene=CBG06092|UniProtKB=A8X0X5	Protein CBR-LET-60	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00006	Apoptosis signaling pathway	P00265	Granzyme B	PANTR|Ensembl=ENSPTRG00000006225|UniProtKB=H2Q840	Uncharacterized protein	ISS			PTHR24271:SF15	GRANZYME H
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	XENTR|Xenbase=XB-GENE-1010483|UniProtKB=F7AF72	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_58093|UniProtKB=C3Z4K3	Putative uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00045	Notch signaling pathway	P01100	CoA	YARLI|EnsemblGenome=YALI0_E02772g|UniProtKB=Q8WZM0	Histone acetyltransferase GCN5	TAS	11112321	PubMed	PTHR22880:SF137	NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	PANTR|Ensembl=ENSPTRG00000017612|UniProtKB=C7G3N0	Glutamate receptor, metabotropic 6	ISS	12488551	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	10747026	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=12775|UniProtKB=O00744	Protein Wnt-10b	IDA	11266476	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	BOVIN|Gene=CACNB1|UniProtKB=Q9MZL7	Voltage-dependent L-type calcium channel subunit beta-1	ISS	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P02771	Pyrimidine Metabolism	P03129	Aminotransferase	CAEEL|WormBase=WBGene00001794|UniProtKB=Q21217	Probable 4-aminobutyrate aminotransferase, mitochondrial	IMP	8133261	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00056	VEGF signaling pathway	P01417	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00059	p53 pathway	P01486	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	CANLF|Ensembl=ENSCAFG00000020209|UniProtKB=E2RPG1	Uncharacterized protein	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00012	Cadherin signaling pathway	P00467	alpha-catenin	DANRE|ZFIN=ZDB-GENE-991207-24|UniProtKB=Q9PVF8	Catenin (Cadherin-associated protein), alpha	IDA	1768802	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P06587	Nicotine pharmacodynamics pathway	P06602	PPP1CA	RAT|RGD=3375|UniProtKB=P62138	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit	ISS	10433257	PubMed	PTHR11668:SF377	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-ALPHA CATALYTIC SUBUNIT
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00020	FAS signaling pathway	P00600	PARP	BOVIN|Gene=PARP1|UniProtKB=P18493	Poly [ADP-ribose] polymerase 1	TAS	12101391	PubMed	PTHR10459:SF80	POLY  ADP-RIBOSE  POLYMERASE 1
P00021	FGF signaling pathway	P00640	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IGI	129387	gi	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01208	Hsp70	DROME|FlyBase=FBgn0001220|UniProtKB=P29845	Heat shock 70 kDa protein cognate 5	IDA	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P00021	FGF signaling pathway	P00632	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	IGI	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00923	Arf1	CHICK|Ensembl=ENSGALG00000011651|UniProtKB=E1BVB0	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P00005	Angiogenesis	P00223	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000002016|UniProtKB=F1P3G1	Protein kinase C delta type	IC	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05918	p38 MAPK pathway	P06020	p38delta	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	RCA	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00034	Integrin signalling pathway	P00933	Crk	CANLF|Ensembl=ENSCAFG00000015188|UniProtKB=E2RF98	Uncharacterized protein	ISS	8649368	PubMed	PTHR19969:SF9	CRK-LIKE PROTEIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=1351340|UniProtKB=Q9QYS2	Metabotropic glutamate receptor 3	IDA	12351712	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	CAEEL|WormBase=WBGene00019962|UniProtKB=O01592	Cysteine synthase 3	ISS			PTHR10314:SF71	CYSTEINE SYNTHASE-RELATED
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	GIAIC|EnsemblGenome=GL50803_40817|UniProtKB=A8BV70	Actin related protein	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00006	Apoptosis signaling pathway	P00302	ATF	MACMU|Ensembl=ENSMMUG00000012095|UniProtKB=F7HB38	Cyclic AMP-dependent transcription factor ATF-1	ISS	11390664	PubMed	PTHR22952:SF258	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04397	p53 pathway by glucose deprivation	P04641	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00475	Frizzled	MOUSE|MGI=MGI=108570|UniProtKB=Q61090	Frizzled-7	IDA	11212302	PubMed	PTHR11309:SF31	FRIZZLED-7
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04398	p53 pathway feedback loops 2	P04651	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-486685|UniProtKB=F6VT32	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P02757	O-antigen biosynthesis	P03046	dTDP-glucose pyrophosphorylase	LEPIN|EnsemblGenome=LA_1662|UniProtKB=G1UB20	Glucose-1-phosphate thymidylyltransferase	ISS			PTHR43532:SF1	GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00057	Wnt signaling pathway	P01457	GBeta	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IDA	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00186	FGFR-1	MACMU|Ensembl=ENSMMUG00000022478|UniProtKB=F7A4U3	Fibroblast growth factor receptor	ISS	12799194	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	MOUSE|MGI=MGI=97356|UniProtKB=Q01768	Nucleoside diphosphate kinase B	ISS			PTHR11349:SF57	NUCLEOSIDE DIPHOSPHATE KINASE B
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	ISS	1482697	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00059	p53 pathway	P04635	Sumo-1 ligase	MACMU|Ensembl=ENSMMUG00000005240|UniProtKB=F7BWQ2	Small ubiquitin-related modifier	ISS			PTHR10562:SF52	SMALL UBIQUITIN-RELATED MODIFIER 1
P00047	PDGF signaling pathway	P01174	Rho	CAEEL|WormBase=WBGene00020209|UniProtKB=H2KZV6	Uncharacterized protein	ISS			PTHR12552:SF1	GRAF ORTHOLOG, ISOFORM G
P00002	Alpha adrenergic receptor signaling pathway	P00078	Alpha1A/1B/1C	TAKRU|Ensembl=ENSTRUG00000012885|UniProtKB=H2U6T8	Uncharacterized protein (Fragment)	IC	11781138	PubMed	PTHR24248:SF0	ALPHA-2DA ADRENERGIC RECEPTOR-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	PANTR|Ensembl=ENSPTRG00000007084|UniProtKB=H2Q9G5	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00052	TGF-beta signaling pathway	P01286	TGFbeta	DROME|FlyBase=FBgn0004885|UniProtKB=Q9VC47	Metalloendopeptidase	TAS	9759503	PubMed	PTHR43978:SF2	DORSAL-VENTRAL PATTERNING PROTEIN TOLLOID-RELATED
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01238	14-3-3	MONDO|Ensembl=ENSMODG00000010174|UniProtKB=F6TA21	Uncharacterized protein	ISS	12917326	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00057	Wnt signaling pathway	P01451	Galpha	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00029	Huntington disease	P00768	Apaf-1	HUMAN|HGNC=576|UniProtKB=O14727	Apoptotic protease-activating factor 1	TAS	14526190	PubMed	PTHR22845:SF5	APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	TAS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000014828|UniProtKB=F1N1E0	Uncharacterized protein	ISS	14624853	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00059	p53 pathway	G01572	NOXA	RAT|RGD=1359266|UniProtKB=Q5U777	Phorbol-12-myristate-13-acetate-induced protein 1	RCA			PTHR14299:SF0	PHORBOL-12-MYRISTATE-13-ACETATE-INDUCED PROTEIN 1
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	FUSNN|EnsemblGenome=FN0240|UniProtKB=Q8RGP6	Thymidylate synthase	ISS			PTHR11548:SF1	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00907	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01167	Ets	ORNAN|Ensembl=ENSOANG00000007395|UniProtKB=F6PQA3	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF171	ETS HOMOLOGOUS FACTOR
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00049	Parkinson disease	P01226	CDCrel-1	CANLF|Ensembl=ENSCAFG00000014533|UniProtKB=F1PCZ0	Uncharacterized protein	ISS	11078524	PubMed	PTHR18884:SF68	SEPTIN-5
P00017	DNA replication	P00530	Top	HUMAN|HGNC=11989|UniProtKB=P11388	DNA topoisomerase 2-alpha	RCA			PTHR10169:SF46	DNA TOPOISOMERASE 2-ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	CANLF|Ensembl=ENSCAFG00000015081|UniProtKB=E2RMT4	Uncharacterized protein	ISS	12963527	gi	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	HUMAN|HGNC=4579|UniProtKB=P39086	Glutamate receptor ionotropic, kainate 1	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P02741	Flavin biosynthesis	P02934	Riboflavin kinase	BACSU|EnsemblGenome=BSU29300|UniProtKB=P94465	RNA-binding riboflavin kinase RibR	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00702	CPB	MACMU|Ensembl=ENSMMUG00000005008|UniProtKB=F6VJI3	Cyclic AMP-responsive element-binding protein 3-like protein 4	ISS			PTHR22952:SF105	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00317	Fos	BOVIN|Ensembl=ENSBTAG00000004322|UniProtKB=O77628	Proto-oncogene c-Fos	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04393	Ras Pathway	P04547	Ras	CHICK|Ensembl=ENSGALG00000014033|UniProtKB=E1BTS2	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P02738	De novo purine biosynthesis	P02902	ADP reductase	DROME|FlyBase=FBgn0011704|UniProtKB=P48592	Ribonucleoside-diphosphate reductase subunit M2	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00021	FGF signaling pathway	P00636	FGFR1-4	BOVIN|Ensembl=ENSBTAG00000014064|UniProtKB=F1MNW2	Fibroblast growth factor receptor	ISS	8089146	PubMed	PTHR24416:SF130	FIBROBLAST GROWTH FACTOR RECEPTOR 2
P00057	Wnt signaling pathway	P01465	Ggamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	CANLF|Ensembl=ENSCAFG00000005204|UniProtKB=B6V8E6	Catenin beta-1	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IDA	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00048	PI3 kinase pathway	P01202	p85	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00021	FGF signaling pathway	P00627	ERK1-2	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000016444|UniProtKB=H2QQ62	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF0	PROTOCADHERIN-10
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01408	Akt/PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	BATDJ|Gene=BATDEDRAFT_15405|UniProtKB=F4NUL6	Alpha-Beta tubulin	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=1351341|UniProtKB=Q68EF4	Metabotropic glutamate receptor 4	ISS	9407094	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P02747	Histidine biosynthesis	P02984	Imidazol glycerol phosphate dehydratase	DEIRA|EnsemblGenome=DR_0424|UniProtKB=Q9RX91	Imidazoleglycerol-phosphate dehydratase	ISS			PTHR23133:SF2	IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00056	VEGF signaling pathway	P01412	HSP27	MACMU|Ensembl=ENSMMUG00000022133|UniProtKB=F7H3G0	Alpha-crystallin B chain	ISS			PTHR11527:SF37	ALPHA-CRYSTALLIN B CHAIN
P00010	B cell activation	P00401	jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	11840290	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00012	Cadherin signaling pathway	P00470	F-actin	PANTR|Ensembl=ENSPTRG00000002086|UniProtKB=H2Q1A9	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P04393	Ras Pathway	P04552	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00018	EGF receptor signaling pathway	P00561	STAT	MACMU|Ensembl=ENSMMUG00000010707|UniProtKB=F7G8G5	Signal transducer and activator of transcription	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00053	T cell activation	P01319	PAK	CANLF|Ensembl=ENSCAFG00000004956|UniProtKB=E2REH3	Uncharacterized protein	ISS	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00034	Integrin signalling pathway	P00916	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	BOVIN|Ensembl=ENSBTAG00000008743|UniProtKB=P20000	Aldehyde dehydrogenase, mitochondrial	IC			PTHR11699:SF233	ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL
P00012	Cadherin signaling pathway	P00467	alpha-catenin	BOVIN|Gene=CTNNA1|UniProtKB=Q3MHM6	Catenin alpha-1	ISS	1904011	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DANRE|ZFIN=ZDB-GENE-000329-3|UniProtKB=Q7ZVF9	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00025	Hedgehog signaling pathway	P00682	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00053	T cell activation	P01336	Jnk	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00021	FGF signaling pathway	P00642	MEK1-2	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00057	Wnt signaling pathway	P01461	FrzB	MOUSE|MGI=MGI=892010|UniProtKB=Q9Z1N6	Secreted frizzled-related sequence protein 4	IDA	9118218	PubMed	PTHR11309:SF7	SECRETED FRIZZLED-RELATED PROTEIN 4
P00006	Apoptosis signaling pathway	P00310	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00057	Wnt signaling pathway	P01435	SWI/SNF	SCHPO|PomBase=SPAC23H3.10|UniProtKB=O14470	SWI/SNF and RSC complexes subunit ssr2	IDA	11532957	PubMed	PTHR12802:SF41	BRAHMA ASSOCIATED PROTEIN 155 KDA
P00053	T cell activation	P01307	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	DROME|FlyBase=FBgn0022724|UniProtKB=Q9VWY6	Transcription initiation factor TFIID subunit 8	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00021	FGF signaling pathway	P00627	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9441|UniProtKB=P51817	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00018	EGF receptor signaling pathway	P00561	STAT	MACMU|Ensembl=ENSMMUG00000010707|UniProtKB=F7G8G5	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	MONDO|Ensembl=ENSMODG00000012761|UniProtKB=F6SJA3	Tyrosine-protein kinase receptor (Fragment)	ISS	249616	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00047	PDGF signaling pathway	P01154	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00048	PI3 kinase pathway	P01202	p85	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	IGI	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	ISS	1171954	gi	PTHR10048:SF14	PI-3 KINASE
P00052	TGF-beta signaling pathway	P01275	P38	DROME|FlyBase=FBgn0015765|UniProtKB=O62618	Mitogen-activated protein kinase 14A	TAS	98079070	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00048	PI3 kinase pathway	P01192	p110	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00269	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00398	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	HUMAN|HGNC=4037|UniProtKB=P06241	Tyrosine-protein kinase Fyn	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	MACMU|Ensembl=ENSMMUG00000021423|UniProtKB=F7EEZ1	Phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DROME|FlyBase=FBgn0259680|UniProtKB=P83099	Putative protein kinase C delta type homolog	ISS	2837282	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00057	Wnt signaling pathway	P01435	SWI/SNF	BOVIN|Ensembl=ENSBTAG00000007494|UniProtKB=A5PKK5	SMARCA2 protein	ISS	11532957	PubMed	PTHR10799:SF541	GLOBAL TRANSCRIPTION ACTIVATOR SNF2L2-RELATED
P04375	5HT3 type receptor mediated signaling pathway	P04425	K+ channel	BOVIN|Ensembl=ENSBTAG00000047488|UniProtKB=G3N1D1	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00049	Parkinson disease	P01227	20S proteasome	TAKRU|Ensembl=ENSTRUG00000001922|UniProtKB=H2RWB3	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF14	PROTEASOME SUBUNIT ALPHA TYPE-5
P00021	FGF signaling pathway	P00638	PLCgamma	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04397	p53 pathway by glucose deprivation	P04639	AMPK	BOVIN|Ensembl=ENSBTAG00000000013|UniProtKB=F1MBG5	Uncharacterized protein	ISS			PTHR24343:SF306	5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	P01455	Smad4	DANRE|ZFIN=ZDB-GENE-110408-38|UniProtKB=E7FGT9	Mothers against decapentaplegic homolog	ISS			PTHR13703:SF34	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG
P05917	Opioid proopiomelanocortin pathway	P06004	Mu or Delta receptor	RAT|RGD=3233|UniProtKB=P33533	Delta-type opioid receptor	RCA	12093103	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P02775	Salvage pyrimidine ribonucleotides	P03156	CDP kinase	CHICK|Ensembl=ENSGALG00000003510|UniProtKB=F1NMM9	Uridine-cytidine kinase	ISS			PTHR10285:SF70	URIDINE-CYTIDINE KINASE 2
P02749	Leucine biosynthesis	P02999	2-Isopropylmalate synthase	SCHPO|PomBase=SPBC3E7.16c|UniProtKB=O59736	2-isopropylmalate synthase	ISS			PTHR10277:SF28	SUBFAMILY NOT NAMED
P00038	JAK/STAT signaling pathway	P01027	STAT	MACMU|Ensembl=ENSMMUG00000010705|UniProtKB=F7G8V4	Signal transducer and activator of transcription	ISS	14662325	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MOUSE|MGI=MGI=87886|UniProtKB=Q91X60	Neuronal acetylcholine receptor subunit alpha-2	IC	85270494	PubMed	PTHR18945:SF757	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	ARATH|TAIR=AT5G58700|UniProtKB=Q944C1	Phosphoinositide phospholipase C 4	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DANRE|ZFIN=ZDB-GENE-030131-55|UniProtKB=Q6XNL8	Actin	IC	14684598	PubMed	PTHR11937:SF263	ACTIN
P00059	p53 pathway	P04630	PP2A	RAT|RGD=3381|UniProtKB=P62716	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000002647|UniProtKB=F7DIB7	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00053	T cell activation	P01316	MHC-antigen	HUMAN|HGNC=914|UniProtKB=P61769	Beta-2-microglobulin	IPI			PTHR19944:SF62	BETA-2-MICROGLOBULIN
P00018	EGF receptor signaling pathway	P00542	EGFR	MACMU|Ensembl=ENSMMUG00000001674|UniProtKB=F7G3H1	Receptor protein-tyrosine kinase	ISS	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P02723	Adenine and hypoxanthine salvage pathway	P02813	Inosine phosphorylase	ANOGA|EnsemblGenome=AGAP005945|UniProtKB=A4Q998	AGAP005945-PA	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	RAT|RGD=69319|UniProtKB=P54313	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00046	Oxidative stress response	P01134	cPLA2	RAT|RGD=67366|UniProtKB=P50393	Cytosolic phospholipase A2	TAS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00019	Endothelin signaling pathway	P00591	PLCbeta	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00011	Blood coagulation	P00410	GP IIb	PANTR|Ensembl=ENSPTRG00000009277|UniProtKB=H2QD72	Uncharacterized protein	ISS	386753	gi	PTHR23220:SF73	INTEGRIN ALPHA-IIB
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04398	p53 pathway feedback loops 2	P04665	AKT	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00045	Notch signaling pathway	P01114	Ntm	MACMU|Ensembl=ENSMMUG00000017022|UniProtKB=F7HQZ9	Uncharacterized protein	ISS	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00029	Huntington disease	P00787	MAPKK4	CANLF|Ensembl=ENSCAFG00000017851|UniProtKB=F1PBB6	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00010	B cell activation	P00375	Calmodulin	ORYSJ|EnsemblGenome=OS01G0267900|UniProtKB=Q0JNS6	Calmodulin-1	ISS	7514101	PubMed	PTHR23050:SF245	AT16150P-RELATED
P06664	Gonadotropin-releasing hormone receptor pathway	P06786	ERK1/2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	RCA	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	HUMAN|HGNC=143|UniProtKB=P68032	Actin, alpha cardiac muscle 1	IC	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	ORNAN|Ensembl=ENSOANG00000009269|UniProtKB=F7ES15	Uncharacterized protein	ISS			PTHR19957:SF83	SYNTAXIN-16
P02738	De novo purine biosynthesis	P02907	dADP kinase	HUMAN|HGNC=7851|UniProtKB=Q13232	Nucleoside diphosphate kinase 3	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PANTR|Ensembl=ENSPTRG00000006890|UniProtKB=H2Q943	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00036	Interleukin signaling pathway	P00990	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IC	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05938	RhoA	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00057	Wnt signaling pathway	P01457	GBeta	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IDA	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P06664	Gonadotropin-releasing hormone receptor pathway	P06759	IRS	MOUSE|MGI=MGI=99454|UniProtKB=P35569	Insulin receptor substrate 1	RCA	11701440	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00018	EGF receptor signaling pathway	P00545	JNK1-3	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	DROME|FlyBase=FBgn0003206|UniProtKB=P04388	Ras-like protein 2	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P05730	Endogenous cannabinoid signaling	P05746	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00006	Apoptosis signaling pathway	P00269	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	MACMU|Ensembl=ENSMMUG00000018136|UniProtKB=F7DHW8	G protein-activated inward rectifier potassium channel 2	ISS	12374786	PubMed	PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	MOUSE|MGI=MGI=1321161|UniProtKB=P62715	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00014	Cholesterol biosynthesis	P00493	Geranyl trans-transferase	ANOGA|EnsemblGenome=AGAP007104|UniProtKB=Q7QIW5	AGAP007104-PA	ISS	O64905	SPACC	PTHR11525:SF0	FARNESYL PYROPHOSPHATE SYNTHASE
P00013	Cell cycle	P00480	Proteasome	MOUSE|MGI=MGI=1351511|UniProtKB=P26516	26S proteasome non-ATPase regulatory subunit 7	ISS	95275316	PubMed	PTHR10540:SF7	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7
P00060	Ubiquitin proteasome pathway	P01491	E2	MOUSE|MGI=MGI=1914500|UniProtKB=Q9QZU9	Ubiquitin/ISG15-conjugating enzyme E2 L6	ISS	11078524	PubMed	PTHR24068:SF43	UBIQUITIN/ISG15-CONJUGATING ENZYME E2 L6
P00010	B cell activation	P00386	Calcineurin	CANLF|Ensembl=ENSCAFG00000014818|UniProtKB=E2RJ59	Serine/threonine-protein phosphatase	ISS	12015605	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00551	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IGI	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01188	Gbetagamma	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	MACMU|Ensembl=ENSMMUG00000002235|UniProtKB=F6VZY3	Uncharacterized protein	ISS			PTHR11454:SF4	INSULIN-LIKE GROWTH FACTOR I
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00012	Cadherin signaling pathway	P00470	F-actin	DAPPU|EnsemblGenome=DAPPUDRAFT_228751|UniProtKB=E9HGF5	Cytoplasmatic actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00048	PI3 kinase pathway	P01185	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00036	Interleukin signaling pathway	P00975	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	8262392	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00036	Interleukin signaling pathway	P00965	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01173	STAT	CHICK|Ensembl=ENSGALG00000003282|UniProtKB=O93378	Signal transducer and activator of transcription	ISS	20119183	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	15531926	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P02757	O-antigen biosynthesis	P03052	N-acetylglucosamine-1-phosphate uridyltransferase	LEPIN|EnsemblGenome=LA_3823|UniProtKB=Q8EZM9	UDP-N-acetylglucosamine diphosphorylase	ISS			PTHR43584:SF3	BIFUNCTIONAL PROTEIN GLMU
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	NAS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	STRCO|Gene=CAB82009|UniProtKB=Q9L0I7	Inosine-5'-monophosphate dehydrogenase	ISS			PTHR11911:SF6	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE
P00034	Integrin signalling pathway	P00948	Rho	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	IGI	12169092	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	TAS	12040174	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00543	ERK1-2	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00552	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P00018	EGF receptor signaling pathway	P00565	PKC	SCHPO|PomBase=SPAC17G8.14c|UniProtKB=P36582	Protein kinase C-like 1	IGI	8491190	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00271	Bax	XENTR|Xenbase=XB-GENE-486067|UniProtKB=Q6P4Y4	BCL2-associated X protein	ISS	11099028	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P00018	EGF receptor signaling pathway	P00552	Ras	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	IGI	22097630	PubMed	PTHR24070:SF189	GTPASE NRAS
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Ensembl=ENSPTRG00000011042|UniProtKB=H2QGF5	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	DICDI|dictyBase=DDB_G0292736|UniProtKB=Q02158	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS			PTHR10336:SF105	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	IDA	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05918	p38 MAPK pathway	P06020	p38delta	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	RCA	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00006	Apoptosis signaling pathway	P00274	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02776	Serine glycine biosynthesis	P03160	Phosphoglycerate dehydrogenase	CAEBR|Gene=CBG20736|UniProtKB=A8XYH5	Protein CBG20736	ISS			PTHR42938:SF5	D-3-PHOSPHOGLYCERATE DEHYDROGENASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	HUMAN|HGNC=16852|UniProtKB=O75159	Suppressor of cytokine signaling 5	ISS	22247722	PubMed	PTHR44282:SF3	SUPPRESSOR OF CYTOKINE SIGNALING 5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	IDA	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DANRE|ZFIN=ZDB-GENE-030131-6503|UniProtKB=Q7ZUC5	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF297	PROTEIN KINASE C DELTA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	RAT|RGD=3784|UniProtKB=P61265	Syntaxin-1B	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P02724	Alanine biosynthesis	P02815	Branched chain amino acid aminotransferase	MACMU|Ensembl=ENSMMUG00000012223|UniProtKB=F6VFZ3	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF51	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, CYTOSOLIC
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	PANTR|Ensembl=ENSPTRG00000008411|UniProtKB=H2QBM1	Uncharacterized protein	ISS	604905	OMIM	PTHR15319:SF1	TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT C
P00021	FGF signaling pathway	P00645	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	15470041	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IDA	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	ANOGA|EnsemblGenome=AGAP010589|UniProtKB=Q7Q8S4	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF3	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA-RELATED
P00029	Huntington disease	P00790	beta-Tubulin	MOUSE|MGI=MGI=107812|UniProtKB=P99024	Tubulin beta-5 chain	TAS	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=5291|UniProtKB=P28566	5-hydroxytryptamine receptor 1E	IDA	12441358	PubMed	PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P05917	Opioid proopiomelanocortin pathway	P06009	K+ channel	CHICK|Ensembl=ENSGALG00000016193|UniProtKB=E1BYI0	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MONDO|Ensembl=ENSMODG00000001775|UniProtKB=F6WJB1	Uncharacterized protein	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CHICK|Ensembl=ENSGALG00000028896|UniProtKB=R4GMK5	Uncharacterized protein	IC	10938134	PubMed	PTHR13140:SF728	MYOSIN HEAVY CHAIN, SKELETAL MUSCLE, ADULT
P02788	Xanthine and guanine salvage pathway	P03247	Xanthine phosphoribosyl transferase	CAEEL|WormBase=WBGene00013690|UniProtKB=Q9NF11	Hypoxanthine PhosphoRibosylTransferase homolog	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00038	JAK/STAT signaling pathway	P01034	Jak	RAT|RGD=69056|UniProtKB=G3V9W2	Tyrosine-protein kinase	ISS	11929133	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	RCA	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	ISS	91072385	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04556	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01179	PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	YEAST|SGD=S000005738|UniProtKB=P18851	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	ORNAN|Ensembl=ENSOANG00000004058|UniProtKB=F6TYP9	Uncharacterized protein	ISS	20112749	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P04393	Ras Pathway	P04572	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00006	Apoptosis signaling pathway	P00274	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	HUMAN|HGNC=10630|UniProtKB=P13236	C-C motif chemokine 4	ISS			PTHR12015:SF103	C-C MOTIF CHEMOKINE 4-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	IC	88234494	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00050	Plasminogen activating cascade	P01258	Fibrin C-terminal truncation	PANTR|Ensembl=ENSPTRG00000016535|UniProtKB=H2QQB5	Uncharacterized protein	ISS	6575700	PubMed	PTHR19143:SF232	FIBRINOGEN ALPHA CHAIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MOUSE|MGI=MGI=1927498|UniProtKB=Q99PG4	Regulator of G-protein signaling 18	IDA	8756726	PubMed	PTHR10845:SF155	REGULATOR OF G-PROTEIN SIGNALING 18
P00029	Huntington disease	P00775	Rac	TAKRU|Ensembl=ENSTRUG00000008289|UniProtKB=H2T7U8	Uncharacterized protein	ISS			PTHR24072:SF129	CDC42L PROTEIN
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00019	Endothelin signaling pathway	P00570	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00045	Notch signaling pathway	P01103	Next	XENTR|Xenbase=XB-GENE-485662|UniProtKB=F7ENN2	Delta-like protein	ISS	11685570	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00012	Cadherin signaling pathway	P00474	Wnt	DANRE|ZFIN=ZDB-GENE-051129-1|UniProtKB=Q4JLT0	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	PANTR|Ensembl=ENSPTRG00000028958|UniProtKB=P79240	C5a anaphylatoxin chemotactic receptor 1	ISS	10352266	PubMed	PTHR24225:SF29	C5A ANAPHYLATOXIN CHEMOTACTIC RECEPTOR 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MACMU|Ensembl=ENSMMUG00000022347|UniProtKB=F6ZCH5	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P05916	Opioid prodynorphin pathway	P06001	AC	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00049	Parkinson disease	P01227	20S proteasome	HUMAN|HGNC=9535|UniProtKB=P60900	Proteasome subunit alpha type-6	TAS	12859888	PubMed	PTHR11599:SF11	PROTEASOME SUBUNIT ALPHA TYPE-6
P00046	Oxidative stress response	P01122	TRX	CAEEL|WormBase=WBGene00021548|UniProtKB=Q9TXY8	Thioredoxin	TAS	12115731	PubMed	PTHR10438:SF369	THIOREDOXIN
P04397	p53 pathway by glucose deprivation	G04706	TSC2	TAKRU|Ensembl=ENSTRUG00000008958|UniProtKB=H2TCY4	Uncharacterized protein	ISS	15249583	PubMed	PTHR10063:SF0	TUBERIN
P00048	PI3 kinase pathway	P01178	Grb2	CAEBR|Gene=CBG16856|UniProtKB=A8XPY6	Protein CBR-SEM-5	ISS	11457149	PubMed	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P04398	p53 pathway feedback loops 2	P04651	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IDA	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00029	Huntington disease	P00807	Actin	ARATH|TAIR=AT3G46520|UniProtKB=P53497	Actin-12	IDA	10974003	PubMed	PTHR11937:SF276	ACTIN-12
P00005	Angiogenesis	P00209	FAK	MONDO|Ensembl=ENSMODG00000000707|UniProtKB=F6WLE6	Uncharacterized protein	ISS	9182576	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00249	PAK	CHICK|Ensembl=ENSGALG00000006426|UniProtKB=E1BS97	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02729	Ascorbate degradation	P02849	L-xylulose kinase	BACSU|EnsemblGenome=BSU40060|UniProtKB=P12011	Gluconokinase	ISS			PTHR43095:SF2	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CHICK|Ensembl=ENSGALG00000009621|UniProtKB=P60706	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00648	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06004	Mu or Delta receptor	BOVIN|Gene=OPRM1|UniProtKB=P79350	Mu-type opioid receptor	RCA	12093103	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00038	JAK/STAT signaling pathway	P01030	SOCS	RAT|RGD=69272|UniProtKB=Q9QX78	Suppressor of cytokine signaling 1	ISS			PTHR44621:SF2	SUPPRESSOR OF CYTOKINE SIGNALING 1
P00054	Toll receptor signaling pathway	P01377	MyD88	MOUSE|MGI=MGI=108005|UniProtKB=P22366	Myeloid differentiation primary response protein MyD88	ISS			PTHR15079:SF3	MYELOID DIFFERENTIATION PRIMARY RESPONSE PROTEIN MYD88
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P02749	Leucine biosynthesis	P03001	3-Isopropylmalate dehydrogenase	AQUAE|EnsemblGenome=aq_244|UniProtKB=O66607	3-isopropylmalate dehydrogenase	ISS			PTHR42979:SF1	3-ISOPROPYLMALATE DEHYDROGENASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00053	T cell activation	P01332	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00047	PDGF signaling pathway	P01160	IP3 receptor	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00023	General transcription regulation	P00658	TBP-associated factors	MONDO|Ensembl=ENSMODG00000003943|UniProtKB=F7FZ67	Uncharacterized protein	ISS			PTHR15137:SF9	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2
P00057	Wnt signaling pathway	P01434	sFRP	BOVIN|Ensembl=ENSBTAG00000018566|UniProtKB=Q9XSC1	Secreted frizzled-related protein 5	ISS	9096311	PubMed	PTHR11309:SF46	SECRETED FRIZZLED-RELATED PROTEIN 5
P02732	Coenzyme A linked carnitine metabolism	P02864	L-carnitine dehydratase	PSEAE|EnsemblGenome=PA3592|UniProtKB=Q9HY34	Uncharacterized protein	ISS			PTHR43949:SF7	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00638	PLCgamma	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P06587	Nicotine pharmacodynamics pathway	P06612	CHRNB3	RAT|RGD=621544|UniProtKB=P12391	Neuronal acetylcholine receptor subunit beta-3	TAS	85270494	PubMed	PTHR18945:SF75	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-3
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00059	p53 pathway	G04694	p110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01006	NR2C	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS			PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04398	p53 pathway feedback loops 2	P04666	cyclin A	PANTR|Ensembl=ENSPTRG00000016410|UniProtKB=H2QQ40	Cyclin A2	ISS			PTHR10177:SF69	CYCLIN-A2
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00052	TGF-beta signaling pathway	P01275	P38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	TAS	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04398	p53 pathway feedback loops 2	P04657	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00951	Jnk	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	IDA	12040174	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00013	Cell cycle	P00486	Cyclin B	DICDI|dictyBase=DDB_G0275493|UniProtKB=P42524	G2/mitotic-specific cyclin-B	IDA	95213312	PubMed	PTHR10177:SF347	G2/MITOTIC-SPECIFIC CYCLIN-B
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	MOUSE|MGI=MGI=99460|UniProtKB=Q61982	Neurogenic locus notch homolog protein 3	IDA	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00057	Wnt signaling pathway	P01444	Wnt	XENTR|Xenbase=XB-GENE-492636|UniProtKB=F7D1A1	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IPI	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05731	GABA-B receptor II signaling	P05755	Gbeta	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	ORYSJ|EnsemblGenome=OS03G0174500|UniProtKB=Q10R17	Adenylosuccinate synthetase 1, chloroplastic	ISS	10636885	PubMed	PTHR11846:SF4	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01465	Ggamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	8687401	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04384	Gamma-aminobutyric acid synthesis	P04482	Glutamate decarboxylase	MACMU|Ensembl=ENSMMUG00000015153|UniProtKB=F6UDM0	Uncharacterized protein	ISS			PTHR11999:SF114	CYSTEINE SULFINIC ACID DECARBOXYLASE
P05917	Opioid proopiomelanocortin pathway	P06007	alpha-MSH	BOVIN|Ensembl=ENSBTAG00000007897|UniProtKB=P01190	Pro-opiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	DICDI|dictyBase=DDB_G0281385|UniProtKB=P32253	Ras-like protein rasC	ISS	8290260	PubMed	PTHR24070:SF251	RAS-LIKE PROTEIN RASC
P04393	Ras Pathway	P04559	Rac	DAPPU|EnsemblGenome=DAPPUDRAFT_299952|UniProtKB=E9FRC3	Putative uncharacterized protein	ISS	12588856	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BOVIN|Ensembl=ENSBTAG00000014614|UniProtKB=P62739	Actin, aortic smooth muscle	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	TAKRU|Ensembl=ENSTRUG00000002246|UniProtKB=H2RYC8	Uncharacterized protein	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P04393	Ras Pathway	P04570	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00219	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	HUMAN|HGNC=17780|UniProtKB=Q562R1	Beta-actin-like protein 2	ISS	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	XENTR|Xenbase=XB-GENE-6469705|UniProtKB=Q6P8G3	Actin, alpha sarcomeric/skeletal	ISS	11889139	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	DROME|FlyBase=FBgn0026136|UniProtKB=O96863	Casein kinase II subunit beta'	IDA	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00059	p53 pathway	P04633	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00221	JNK1	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P02752	Mannose metabolism	P03018	Mannose 1-P guanylyl transferase	MONDO|Ensembl=ENSMODG00000015078|UniProtKB=F7F3V5	Uncharacterized protein	ISS	12477932	PubMed	PTHR22572:SF104	MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE ALPHA
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P02736	Coenzyme A biosynthesis	P02882	Pantothenate cysteine ligase	RAT|RGD=1311399|UniProtKB=D4A6X7	Protein Ppcs	ISS			PTHR12290:SF2	PHOSPHOPANTOTHENATE--CYSTEINE LIGASE
P00046	Oxidative stress response	P01126	ATF2	HUMAN|HGNC=784|UniProtKB=P15336	Cyclic AMP-dependent transcription factor ATF-2	TAS	15218628	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00848	Grb	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	11384839	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IDA	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00034	Integrin signalling pathway	P00912	Arp2/3	CHICK|Ensembl=ENSGALG00000004693|UniProtKB=Q5ZJI7	Uncharacterized protein	ISS	12963527	gi	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00049	Parkinson disease	P01238	14-3-3	ANOGA|EnsemblGenome=AGAP007643|UniProtKB=A0NBC2	AGAP007643-PA	ISS	10407019	PubMed	PTHR18860:SF13	14-3-3 PROTEIN ZETA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12701063	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00036	Interleukin signaling pathway	P00985	PDK1/2	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	ISS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	BOVIN|Ensembl=ENSBTAG00000012628|UniProtKB=F1MUJ6	Uncharacterized protein	ISS	96032356	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P00057	Wnt signaling pathway	P01443	Phospholipase C	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00005	Angiogenesis	P00235	c-Fos	BOVIN|Ensembl=ENSBTAG00000004322|UniProtKB=O77628	Proto-oncogene c-Fos	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00004	Alzheimer disease-presenilin pathway	P00146	Afadin	MOUSE|MGI=MGI=1314653|UniProtKB=Q9QZQ1	Afadin	ISS	10974003	PubMed	PTHR10398:SF1	AFADIN
P00047	PDGF signaling pathway	P01151	PKB	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01155	Jak	BOVIN|Ensembl=ENSBTAG00000003147|UniProtKB=F1N0D6	Tyrosine-protein kinase	ISS	9637709	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	IDA	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00633	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00010	B cell activation	P00379	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00010	B cell activation	P00379	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00589	Akt	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	ISS	12655147	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01192	p110	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	DROME|FlyBase=FBgn0004619|UniProtKB=Q03445	Glutamate receptor 1	IC	10331083	PubMed	PTHR18966:SF270	GLUTAMATE RECEPTOR 1-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00005	Angiogenesis	P00205	GAP	ORNAN|Ensembl=ENSOANG00000014753|UniProtKB=F7EPN2	Uncharacterized protein (Fragment)	ISS	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00012	Cadherin signaling pathway	P00470	F-actin	CHLRE|EnsemblGenome=CHLREDRAFT_168932|UniProtKB=O24426	Actin-like protein	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	ARATH|TAIR=AT2G31300|UniProtKB=Q9SJW6	Actin-related protein 2/3 complex subunit 1B	ISS	12963527	gi	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	HUMAN|HGNC=6008|UniProtKB=P01589	Interleukin-2 receptor subunit alpha	IPI	11886175	PubMed	PTHR10573:SF0	INTERLEUKIN-2 RECEPTOR SUBUNIT ALPHA
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000015130|UniProtKB=H2QMZ0	Uncharacterized protein	ISS	11067767	PubMed	PTHR19957:SF29	SYNTAXIN-19
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05913	Enkephalin release	P05974	G-Protein (i)	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	IC	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00008	Axon guidance mediated by Slit/Robo	P00352	DCC	MONDO|Ensembl=ENSMODG00000011028|UniProtKB=F7F4D5	Uncharacterized protein	ISS	12798294	PubMed	PTHR44146:SF3	NETRIN RECEPTOR DCC
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00038	JAK/STAT signaling pathway	P01027	STAT	MONDO|Ensembl=ENSMODG00000028212|UniProtKB=F7BYN4	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00019	Endothelin signaling pathway	P00572	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	RAT|RGD=68942|UniProtKB=O54898	Voltage-dependent T-type calcium channel subunit alpha-1G	ISS	14526084	PubMed	PTHR10037:SF137	VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1G
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	MOUSE|MGI=MGI=1859867|UniProtKB=Q9R0N6	Synaptotagmin-8	RCA			PTHR10024:SF249	SYNAPTOTAGMIN-8
P00021	FGF signaling pathway	P00623	FGF	PANTR|Ensembl=ENSPTRG00000016209|UniProtKB=H2QPS2	Fibroblast growth factor	ISS			PTHR11486:SF23	FIBROBLAST GROWTH FACTOR 5
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00038	JAK/STAT signaling pathway	P01027	STAT	MONDO|Ensembl=ENSMODG00000028212|UniProtKB=F7BYN4	Signal transducer and activator of transcription	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00003	Alzheimer disease-amyloid secretase pathway	P00092	TACE	MOUSE|MGI=MGI=1096335|UniProtKB=Q9Z0F8	Disintegrin and metalloproteinase domain-containing protein 17	IDA	12834808	PubMed	PTHR11905:SF171	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P05734	Synaptic vesicle trafficking	P05774	NSF	CHICK|Ensembl=ENSGALG00000001055|UniProtKB=E1BQU4	Uncharacterized protein	ISS	7969419	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	94280860	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00019	Endothelin signaling pathway	P00587	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04454	CRF	HUMAN|HGNC=2355|UniProtKB=P06850	Corticoliberin	ISS	122560	OMIM	PTHR15035:SF9	CORTICOLIBERIN
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	BOVIN|Ensembl=ENSBTAG00000037726|UniProtKB=P10895	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	TAS			PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TAKRU|Ensembl=ENSTRUG00000014318|UniProtKB=H2UI49	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P02783	Tryptophan biosynthesis	P03210	Indole-3-glycerol phosphate synthase	LEPIN|EnsemblGenome=LA_0840|UniProtKB=Q8F7V2	Indole-3-glycerol phosphate synthase	ISS			PTHR22854:SF2	TRYPTOPHAN BIOSYNTHESIS PROTEIN TRPCF
P00053	T cell activation	P01311	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	IEA	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	MACMU|Ensembl=ENSMMUG00000021944|UniProtKB=F6T3U2	Transcription initiation factor TFIID subunit 7	ISS			PTHR12228:SF6	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 7
P00029	Huntington disease	P00807	Actin	ORYSJ|EnsemblGenome=OS05G0438800|UniProtKB=Q75HX0	Actin	IDA	11889126	PubMed	PTHR11937:SF248	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00005	Angiogenesis	P00255	Notch	RAT|RGD=1303282|UniProtKB=Q6MG89	Notch homolog 4, [Drosophila]	ISS	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P04380	Cortocotropin releasing factor receptor signaling pathway	P04453	ACTH	MACMU|Ensembl=ENSMMUG00000016463|UniProtKB=F7GBI0	Uncharacterized protein	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CANLF|Ensembl=ENSCAFG00000011689|UniProtKB=E2QZY2	Uncharacterized protein	ISS	11259487	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	HUMAN|HGNC=4404|UniProtKB=P59768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IDA	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00036	Interleukin signaling pathway	P00997	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	10982827	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00006	Apoptosis signaling pathway	P00318	PKCs	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CAEBR|Gene=CBG05858|UniProtKB=A8X1H0	Protein CBR-EGL-19 (Fragment)	ISS	11956331	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00047	PDGF signaling pathway	P01155	Jak	MACMU|Ensembl=ENSMMUG00000014558|UniProtKB=F7GT47	Tyrosine-protein kinase	ISS	22482294	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000010392|UniProtKB=F7ASR8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IC	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00047	PDGF signaling pathway	P01150	PKC	PANTR|Ensembl=ENSPTRG00000000931|UniProtKB=H2PZC4	Protein kinase N2	ISS	10644715	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	ORNAN|Ensembl=ENSOANG00000006415|UniProtKB=F6WIC7	Uncharacterized protein	ISS	12374786	PubMed	PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	TAKRU|Ensembl=ENSTRUG00000015959|UniProtKB=H2UV27	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00035	Interferon-gamma signaling pathway	P00960	PTP	MACMU|Ensembl=ENSMMUG00000013253|UniProtKB=F6ZJD8	Tyrosine-protein phosphatase non-receptor type	ISS	14534538	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00005	Angiogenesis	P00205	GAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	20908895	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	PANTR|Ensembl=ENSPTRG00000003502|UniProtKB=H2Q3E9	Uncharacterized protein	ISS	96032356	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04547	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	DEIRA|EnsemblGenome=DR_0302|UniProtKB=Q9RXK9	Glutamine--fructose-6-phosphate aminotransferase [isomerizing]	ISS			PTHR10937:SF0	GH12731P-RELATED
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00029	Huntington disease	P00786	ARF	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g166872|UniProtKB=A7S615	Predicted protein	ISS	12932731	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	MACMU|Ensembl=ENSMMUG00000020134|UniProtKB=F6U055	Uncharacterized protein	ISS	12356903	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00011	Blood coagulation	P00447	FVIIa	HUMAN|HGNC=3544|UniProtKB=P08709	Coagulation factor VII	ISS	10518503	gi	PTHR44064:SF1	COAGULATION FACTOR VII
P00059	p53 pathway	P01486	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00023	General transcription regulation	P00658	TBP-associated factors	RAT|RGD=1308423|UniProtKB=D3ZY89	Protein Taf8	ISS	604904	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00029	Huntington disease	P00787	MAPKK4	PANTR|Ensembl=ENSPTRG00000008783|UniProtKB=H2QCA7	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P06587	Nicotine pharmacodynamics pathway	P06596	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8051109	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00036	Interleukin signaling pathway	P00965	ERK	BOVIN|Ensembl=ENSBTAG00000005865|UniProtKB=G5E577	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00015	Circadian clock system	G01499	per	HUMAN|HGNC=8845|UniProtKB=O15534	Period circadian protein homolog 1	IDA	12782655	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P00009	Axon guidance mediated by netrin	P00357	Netrin	HUMAN|HGNC=8030|UniProtKB=O00634	Netrin-3	ISS			PTHR10574:SF292	NETRIN-3
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04393	Ras Pathway	P04567	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00047	PDGF signaling pathway	P01150	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	CHICK|Ensembl=ENSGALG00000014033|UniProtKB=E1BTS2	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	8836152	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P04393	Ras Pathway	P04565	MKK4/7	HUMAN|HGNC=6844|UniProtKB=P45985	Dual specificity mitogen-activated protein kinase kinase 4	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00057	Wnt signaling pathway	P01438	PP2A	CANLF|Ensembl=ENSCAFG00000006453|UniProtKB=F6X958	Serine/threonine-protein phosphatase	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04395	Vasopressin synthesis	P04593	Glycopeptide	MACMU|Ensembl=ENSMMUG00000010678|UniProtKB=F7AXI7	Uncharacterized protein	ISS	1706187	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00049	Parkinson disease	P01227	20S proteasome	RAT|RGD=621093|UniProtKB=Q9JHW0	Proteasome subunit beta type-7	ISS	12859888	PubMed	PTHR11599:SF42	PROTEASOME SUBUNIT BETA TYPE-7
P00047	PDGF signaling pathway	P01160	IP3 receptor	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00021	FGF signaling pathway	P00638	PLCgamma	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P02785	Valine biosynthesis	P03217	Dihydroxy isovalerate reductoisomerase	BACTN|EnsemblGenome=BT_2074|UniProtKB=Q8A612	Ketol-acid reductoisomerase (NADP(+))	ISS			PTHR21371:SF1	KETOL-ACID REDUCTOISOMERASE, CHLOROPLASTIC
P00005	Angiogenesis	P00251	cPLA2	HUMAN|HGNC=9036|UniProtKB=P0C869	Cytosolic phospholipase A2 beta	RCA			PTHR10728:SF32	CYTOSOLIC PHOSPHOLIPASE A2 BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CAEBR|Gene=CBG17587|UniProtKB=A8XRA5	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02738	De novo purine biosynthesis	P02905	Amidophosphoribosyl transferase	SULSO|EnsemblGenome=SSO0633|UniProtKB=Q7LXR3	Amidophosphoribosyltransferase (Glutamine phosphoribosylpyrophosphate amidotransferase) (ATase) (GPAT) (PurF-2)	ISS			PTHR11907:SF17	SUBFAMILY NOT NAMED
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02738	De novo purine biosynthesis	P02900	AICAR transformylase	STRCO|EnsemblGenome=CAB92677|UniProtKB=Q9KY50	Bifunctional purine biosynthesis protein PurH	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P00049	Parkinson disease	P01212	p38 MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04398	p53 pathway feedback loops 2	P04657	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P06959	CCKR signaling map	P07086	PLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	RCA	9462714	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04393	Ras Pathway	P04541	p90RSK	BOVIN|Ensembl=ENSBTAG00000014447|UniProtKB=A4IFF4	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00047	PDGF signaling pathway	P01148	Grb2	CAEEL|WormBase=WBGene00004774|UniProtKB=P29355	Sex muscle abnormal protein 5	ISS	51702266	gi	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	PANTR|Ensembl=ENSPTRG00000003983|UniProtKB=H2Q4A0	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IGI	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00059	p53 pathway	P04623	CBP	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P02768	Proline biosynthesis	P03114	Glutamyl kinase	STRCO|EnsemblGenome=CAB66265|UniProtKB=Q9RDJ9	Glutamate 5-kinase	ISS			PTHR43654:SF3	GLUTAMATE 5-KINASE
P00021	FGF signaling pathway	P00629	PP2A	CAEBR|Gene=CBG23076|UniProtKB=A8Y4R8	Protein CBR-PPTR-2	ISS	10092233	PubMed	PTHR10257:SF3	PP2A-B', ISOFORM B
P00029	Huntington disease	P00799	JNK-2	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00049	Parkinson disease	P01241	TH	PANTR|Ensembl=ENSPTRG00000003173|UniProtKB=H2Q2W7	Uncharacterized protein	ISS	191290	OMIM	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BOVIN|Ensembl=ENSBTAG00000005570|UniProtKB=E1BKL2	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P05913	Enkephalin release	P05974	G-Protein (i)	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00223	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04397	p53 pathway by glucose deprivation	P04641	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00552	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00047	PDGF signaling pathway	P01173	STAT	CANLF|Ensembl=ENSCAFG00000015509|UniProtKB=F1PNW8	Signal transducer and activator of transcription	ISS	8732682	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00034	Integrin signalling pathway	P00925	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IDA	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	DANRE|ZFIN=ZDB-GENE-040116-1|UniProtKB=Q7ZUQ0	Actin related protein 2/3 complex, subunit 1A	ISS	12473693	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	XENTR|Xenbase=XB-GENE-957124|UniProtKB=F7BDN8	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	DANRE|ZFIN=ZDB-GENE-020125-4|UniProtKB=F1QKT1	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00048	PI3 kinase pathway	P01192	p110	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00015	Circadian clock system	G01497	cry	MOUSE|MGI=MGI=1270859|UniProtKB=Q9R194	Cryptochrome-2	IDA	14507900	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00049	Parkinson disease	P01208	Hsp70	PHYPA|Gene=PHYPADRAFT_230273|UniProtKB=A9SNF1	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P05913	Enkephalin release	P05972	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00219	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00029	Huntington disease	P00790	beta-Tubulin	DICDI|dictyBase=DDB_G0269196|UniProtKB=P32256	Tubulin beta chain	TAS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00019	Endothelin signaling pathway	P00580	ET-RA/B	PANTR|Ensembl=ENSPTRG00000016494|UniProtKB=H2QQ94	Endothelin receptor type A	ISS	91195317	PubMed	PTHR24243:SF31	ENDOTHELIN-1 RECEPTOR
P00018	EGF receptor signaling pathway	P00564	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	MACMU|Ensembl=ENSMMUG00000009607|UniProtKB=F7A586	5-hydroxytryptamine receptor 2C	ISS	12181435	PubMed	PTHR24247:SF32	5-HYDROXYTRYPTAMINE RECEPTOR 2C
P04393	Ras Pathway	P04547	Ras	CAEBR|Gene=CBG06092|UniProtKB=A8X0X5	Protein CBR-LET-60	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00047	PDGF signaling pathway	P01155	Jak	MOUSE|MGI=MGI=96629|UniProtKB=Q62120	Tyrosine-protein kinase JAK2	ISS	22482294	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00055	Transcription regulation by bZIP transcription factor	P01390	TFIIA complex	SCHPO|PomBase=SPBC28F2.09|UniProtKB=Q9USU9	Transcription initiation factor IIA large subunit	ISS	600519	OMIM	PTHR12694:SF8	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	HUMAN|HGNC=1073|UniProtKB=P22004	Bone morphogenetic protein 6	TAS	9759503	PubMed	PTHR11848:SF137	BONE MORPHOGENETIC PROTEIN 6
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05918	p38 MAPK pathway	P05920	MAPKAP-K2	BOVIN|Ensembl=ENSBTAG00000038107|UniProtKB=F1MCX5	Uncharacterized protein	ISS	10779545	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00047	PDGF signaling pathway	P01143	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01153	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00005	Angiogenesis	P00254	GTPase	CHICK|Ensembl=ENSGALG00000003806|UniProtKB=O93467	GTP-binding protein	ISS	12169092	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00059	p53 pathway	P04623	CBP	ARATH|TAIR=AT3G12980|UniProtKB=Q9LE42	Histone acetyltransferase HAC5	IDA	8413673	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CAEEL|WormBase=WBGene00000064|UniProtKB=P10984	Actin-2	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00030	Hypoxia response via HIF activation	P00819	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	22246731	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00049	Parkinson disease	P01238	14-3-3	ARATH|TAIR=AT1G34760|UniProtKB=Q9S9Z8	14-3-3-like protein GF14 omicron	IDA	10407019	PubMed	PTHR18860:SF32	14-3-3 FAMILY PROTEIN-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	RAT|RGD=619966|UniProtKB=F1LQT1	Adenylate cyclase 7	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00054	Toll receptor signaling pathway	P01381	Ubc13	CHICK|Ensembl=ENSGALG00000011292|UniProtKB=F1NFT6	Uncharacterized protein	ISS			PTHR43902:SF2	UBIQUITIN-CONJUGATING ENZYME E2 N
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	IDA	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05913	Enkephalin release	P05974	G-Protein (i)	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05915	Opioid proenkephalin pathway	P05985	Mu or Delta receptor	MOUSE|MGI=MGI=97441|UniProtKB=P42866	Mu-type opioid receptor	RCA	12093103	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00057	Wnt signaling pathway	P01438	PP2A	RAT|RGD=1308022|UniProtKB=D3ZDI7	Protein Ppp2r5a	ISS	10092233	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P02785	Valine biosynthesis	P03215	Branched chain amino acid aminotransferase	CANLF|Ensembl=ENSCAFG00000011487|UniProtKB=F1PY28	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF51	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, CYTOSOLIC
P00021	FGF signaling pathway	P00634	MEKK1-5	HUMAN|HGNC=6856|UniProtKB=Q9Y6R4	Mitogen-activated protein kinase kinase kinase 4	IGI	11730323	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000017389|UniProtKB=H2R334	Uncharacterized protein	ISS			PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P00048	PI3 kinase pathway	P01179	PKB	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00775	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	TAS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00269	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	21150461	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00048	PI3 kinase pathway	P01206	14-3-3	MONDO|Ensembl=ENSMODG00000015951|UniProtKB=F7FRT9	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=620146|UniProtKB=O08874	Serine/threonine-protein kinase N2	ISS	125549	gi	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	XENTR|Xenbase=XB-GENE-5755296|UniProtKB=F7ELS1	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF76	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	IC	176892	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00029	Huntington disease	P00778	NMDA receptor	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=282|UniProtKB=P18089	Alpha-2B adrenergic receptor	IDA	11781138	PubMed	PTHR24248:SF26	ALPHA-2B ADRENERGIC RECEPTOR
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00219	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00021	FGF signaling pathway	P00632	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00030	Hypoxia response via HIF activation	P00819	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IC	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00539	14-3-3	PANTR|Ensembl=ENSPTRG00000013529|UniProtKB=H2R8X6	Uncharacterized protein	ISS	12618428	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00023	General transcription regulation	P00669	TFIIEalpha	HUMAN|HGNC=4650|UniProtKB=P29083	General transcription factor IIE subunit 1	IGI	189964	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00059	p53 pathway	P04609	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000001583|UniProtKB=F7BBM1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P05916	Opioid prodynorphin pathway	P06002	G-protein	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P05730	Endogenous cannabinoid signaling	P05751	Galpha	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000022319|UniProtKB=F6XDA0	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00029	Huntington disease	P00780	Microtubule	DROME|FlyBase=FBgn0052396|UniProtKB=Q9VRX3	Probable tubulin beta chain CG32396	IDA	12932731	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00056	VEGF signaling pathway	P01408	Akt/PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	PANTR|Ensembl=ENSPTRG00000021282|UniProtKB=H2R051	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF4	REGULATOR OF G-PROTEIN SIGNALING 3
P00023	General transcription regulation	P00658	TBP-associated factors	BOVIN|Ensembl=ENSBTAG00000015333|UniProtKB=F1MME0	Uncharacterized protein	ISS			PTHR15137:SF9	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	CAEBR|Gene=CBG04234|UniProtKB=A8WWH4	Protein CBR-CCB-2	ISS			PTHR11824:SF10	CALCIUM CHANNEL, BETA SUBUNIT
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	XENTR|Xenbase=XB-GENE-967585|UniProtKB=Q28BZ0	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	ORYSJ|EnsemblGenome=OS01G0570500|UniProtKB=Q656Y0	Os01g0570500 protein	IDA	10617630	PubMed	PTHR11909:SF162	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IDA	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01145	c-fos	PANTR|Ensembl=ENSPTRG00000006553|UniProtKB=A5A6H0	C-fos	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04393	Ras Pathway	P04572	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=2322|UniProtKB=P55280	Cadherin-6	IDA	8120095	PubMed	PTHR24027:SF322	CADHERIN-6
P05912	Dopamine receptor mediated signaling pathway	P05949	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	15210125	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	IC	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00021	FGF signaling pathway	P00644	p38	CAEEL|WormBase=WBGene00004055|UniProtKB=Q17446	Mitogen-activated protein kinase pmk-1	IGI	10851062	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00021	FGF signaling pathway	P00633	Ras	XENTR|Xenbase=XB-GENE-494548|UniProtKB=F7EC26	Uncharacterized protein	ISS	20362513	PubMed	PTHR24070:SF186	GTPASE KRAS
P00019	Endothelin signaling pathway	P00584	Gs	MACMU|Ensembl=ENSMMUG00000010266|UniProtKB=F6PV18	Uncharacterized protein	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=2136748|UniProtKB=Q91Y06	Protein Pcdhb13	IDA	8120095	PubMed	PTHR24028:SF104	PROTOCADHERIN BETA-6
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	HUMAN|HGNC=4573|UniProtKB=P42263	Glutamate receptor 3	ISS	12871085	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01305	Calmodulin	PUCGT|EnsemblGenome=PGTG_11337|UniProtKB=E3KLJ3	Calmodulin	ISS			PTHR23050:SF245	AT16150P-RELATED
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00019	Endothelin signaling pathway	P00591	PLCbeta	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00018	EGF receptor signaling pathway	G01511	SPRY	PANTR|Ensembl=ENSPTRG00000005951|UniProtKB=H2Q7P2	Sprouty homolog 2	ISS	12815057	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	SYNY3|EnsemblGenome=BAA10498|UniProtKB=Q55404	Acetyl-coenzyme A synthetase	ISS			PTHR24095:SF14	ACETYL-COENZYME A SYNTHETASE 1
P00029	Huntington disease	P00807	Actin	ORYSJ|EnsemblGenome=OS03G0836000|UniProtKB=Q10AZ4	Actin-3	IDA	14684598	PubMed	PTHR11937:SF254	ACTIN-1-RELATED
P04393	Ras Pathway	P04567	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01443	Phospholipase C	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	IDA	10571227	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P06959	CCKR signaling map	G07264	TFF2	HUMAN|HGNC=11756|UniProtKB=Q03403	Trefoil factor 2	RCA	17332476	PubMed	PTHR13826:SF17	TREFOIL FACTOR 2
P00059	p53 pathway	G04694	p110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	IC	14698601	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	DANRE|ZFIN=ZDB-GENE-020125-3|UniProtKB=E7F1V8	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P05730	Endogenous cannabinoid signaling	P05746	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	IDA	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	PANTR|Ensembl=ENSPTRG00000012427|UniProtKB=H2QIN7	Mitogen-activated protein kinase kinase kinase 2	ISS	8621389	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	RAT|RGD=2847|UniProtKB=P28565	5-hydroxytryptamine receptor 1D	IDA			PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	IDA	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	BOVIN|Ensembl=ENSBTAG00000019988|UniProtKB=F1N2V3	Uncharacterized protein	ISS	11359849	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	XENTR|Xenbase=XB-GENE-490883|UniProtKB=Q6NVA9	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IC	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	BOVIN|Gene=IGF2R|UniProtKB=P08169	Cation-independent mannose-6-phosphate receptor	ISS	13642251	gi	PTHR15071:SF17	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	CAEEL|WormBase=WBGene00004769|UniProtKB=P52166	Presenilin sel-12	IDA	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00037	Ionotropic glutamate receptor pathway	P01021	Vglut	CANLF|Ensembl=ENSCAFG00000010093|UniProtKB=F1PBW6	Uncharacterized protein	ISS	12815758	PubMed	PTHR11662:SF201	VESICULAR GLUTAMATE TRANSPORTER 2
P00029	Huntington disease	P00778	NMDA receptor	MOUSE|MGI=MGI=95821|UniProtKB=Q01097	Glutamate receptor ionotropic, NMDA 2B	IDA	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	RAT|RGD=2521|UniProtKB=P19020	D(3) dopamine receptor	ISS	2137198	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P05916	Opioid prodynorphin pathway	P06001	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00059	p53 pathway	P04609	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01439	C-terminal Binding Protein	CAEEL|WormBase=WBGene00006424|UniProtKB=Q20595	C-terminal-binding protein 1	IDA	10375506	PubMed	PTHR10996:SF173	C-TERMINAL-BINDING PROTEIN
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00036	Interleukin signaling pathway	P00962	ELK	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	IC	11279280	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00034	Integrin signalling pathway	P00925	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	ANOGA|EnsemblGenome=AGAP011166|UniProtKB=Q7PSR8	Serine/threonine-protein phosphatase	ISS	8392016	PubMed	PTHR11668:SF402	SERINE/THREONINE-PROTEIN PHOSPHATASE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P02730	Asparagine and aspartate biosynthesis	P02853	Asparagine synthetase	BACSU|EnsemblGenome=BSU39920|UniProtKB=P42113	Asparagine synthetase [glutamine-hydrolyzing] 2	ISS			PTHR43284:SF2	SUBFAMILY NOT NAMED
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01461	FrzB	DANRE|ZFIN=ZDB-GENE-990715-1|UniProtKB=Q9W6E0	Frizzled-related protein	IDA	9118218	PubMed	PTHR11309:SF96	FRIZZLED-RELATED PROTEIN
P00016	Cytoskeletal regulation by Rho GTPase	P00513	Op18/stathmin	BOVIN|Ensembl=ENSBTAG00000013761|UniProtKB=Q3T0C7	Stathmin	ISS	http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=3925	Website	PTHR10104:SF5	STATHMIN
P00047	PDGF signaling pathway	P01174	Rho	MOUSE|MGI=MGI=1923367|UniProtKB=Q811M1	Rho GTPase-activating protein 15	ISS	8288572	PubMed	PTHR23181:SF5	RHO GTPASE-ACTIVATING PROTEIN 15
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008422|UniProtKB=F6VUT7	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	RCA	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	HUMAN|HGNC=17780|UniProtKB=Q562R1	Beta-actin-like protein 2	ISS	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	TAS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00240	FRS-2	MOUSE|MGI=MGI=1100860|UniProtKB=Q8C180	Fibroblast growth factor receptor substrate 2	ISS	12571252	PubMed	PTHR21258:SF40	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00206	Wnt	RAT|RGD=621346|UniProtKB=Q2IBD1	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=3036262|UniProtKB=Q3USB7	Inactive phospholipase C-like protein 1	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	HUMAN|HGNC=6026|UniProtKB=P25024	C-X-C chemokine receptor type 1	IPI	6753456	gi	PTHR10489:SF916	C-X-C CHEMOKINE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00644	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	ISS	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	P01444	Wnt	DROME|FlyBase=FBgn0010453|UniProtKB=P40589	Protein Wnt-4	ISS	8717036	PubMed	PTHR12027:SF102	PROTEIN WNT-4
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	IDA	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00048	PI3 kinase pathway	P01197	Caspase-9	HUMAN|HGNC=1511|UniProtKB=P55211	Caspase-9	ISS	8663294	PubMed	PTHR10454:SF157	CASPASE-9
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00005	Angiogenesis	P00223	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02738	De novo purine biosynthesis	P02909	GDP reductase	MONDO|Ensembl=ENSMODG00000008391|UniProtKB=F7A4H4	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MACMU|Ensembl=ENSMMUG00000009600|UniProtKB=F7AC65	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF291	ADENYLATE CYCLASE TYPE 3
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MOUSE|MGI=MGI=88313|UniProtKB=P25322	G1/S-specific cyclin-D1	ISS	12356903	PubMed	PTHR10177:SF67	G1/S-SPECIFIC CYCLIN-D1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00385	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	IGI	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00017	DNA replication	P00527	Histones	MACMU|Ensembl=ENSMMUG00000029404|UniProtKB=F6XLZ2	Uncharacterized protein	ISS	12413958	PubMed	PTHR11426:SF173	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04665	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00521	Profilin	PANTR|Ensembl=ENSPTRG00000008616|UniProtKB=H2QBZ3	Profilin	ISS			PTHR13936:SF14	PROFILIN-1
P02726	Aminobutyrate degradation	P02825	4-aminobutyrate aminotransferase	SCHPO|PomBase=SPAC19D5.07|UniProtKB=O13837	4-aminobutyrate aminotransferase	ISS	8133261	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00024	Glycolysis	P00679	Aldolase	DROME|FlyBase=FBgn0000064|UniProtKB=P07764	Fructose-bisphosphate aldolase	ISS	2133662	gi	PTHR11627:SF20	FRUCTOSE-BISPHOSPHATE ALDOLASE
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IC	3755548	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00005	Angiogenesis	P00205	GAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00972	MNK1/2	BOVIN|Gene=MKNK1|UniProtKB=Q58D94	MAP kinase-interacting serine/threonine-protein kinase 1	ISS	11575158	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00983	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00049	Parkinson disease	P01227	20S proteasome	BOVIN|Ensembl=ENSBTAG00000020641|UniProtKB=Q5E987	Proteasome subunit alpha type-5	ISS	12859888	PubMed	PTHR11599:SF14	PROTEASOME SUBUNIT ALPHA TYPE-5
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00059	p53 pathway	P04630	PP2A	DANRE|ZFIN=ZDB-GENE-040426-2487|UniProtKB=Q803G3	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00010	B cell activation	P00391	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00729	Goalpha	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	PSEAE|EnsemblGenome=PA0350|UniProtKB=Q9I6E3	Dihydrofolate reductase	ISS			PTHR22778:SF16	DIHYDROFOLATE REDUCTASE
P02746	Heme biosynthesis	P02972	Ferrochelatase	BRADU|EnsemblGenome=BAC53017|UniProtKB=P28602	Ferrochelatase	ISS			PTHR11108:SF1	FERROCHELATASE, MITOCHONDRIAL
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IDA	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	PANTR|Ensembl=ENSPTRG00000010386|UniProtKB=H2QF61	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF402	INSULIN RECEPTOR
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	11956331	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00012	Cadherin signaling pathway	P00470	F-actin	MACMU|Ensembl=ENSMMUG00000002263|UniProtKB=F6VEE0	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00052	TGF-beta signaling pathway	P01284	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DROME|FlyBase=FBgn0003093|UniProtKB=P13678	Protein kinase C	IC	3755548	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CAEEL|WormBase=WBGene00001615|UniProtKB=Q17697	GLutamate Receptor family (AMPA)	IC	12941441	PubMed	PTHR18966:SF352	GLUTAMATE RECEPTOR FAMILY  AMPA
P00054	Toll receptor signaling pathway	P01360	IKKbeta	MOUSE|MGI=MGI=1338071|UniProtKB=O88351	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IDA	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	SCHPO|PomBase=SPBC32H8.07|UniProtKB=Q10282	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	RAT|RGD=620024|UniProtKB=P31325	Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	IDA	1370475	PubMed	PTHR44087:SF2	PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, LIVER/TESTIS ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00951	Jnk	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00046	Oxidative stress response	P01129	JNK1/2	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00018	EGF receptor signaling pathway	P00551	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IGI	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00870	IL2	MOUSE|MGI=MGI=107364|UniProtKB=Q62386	Interleukin-17A	TAS			PTHR44866:SF1	INTERLEUKIN-17A
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	MYCTU|EnsemblGenome=Rv1392|UniProtKB=P9WGV1	S-adenosylmethionine synthase	ISS			PTHR11964:SF1	S-ADENOSYLMETHIONINE SYNTHASE
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00056	VEGF signaling pathway	P01407	Erk	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	HUMAN|HGNC=1953|UniProtKB=P08173	Muscarinic acetylcholine receptor M4	ISS	91373358	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	IDA	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00590	IP3 R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	CHICK|Ensembl=ENSGALG00000006885|UniProtKB=P08642	GTPase HRas	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00052	TGF-beta signaling pathway	P01279	Smurfs	PANTR|Ensembl=ENSPTRG00000009546|UniProtKB=H2QDP6	SMAD specific E3 ubiquitin protein ligase 2	ISS	11252892	PubMed	PTHR11254:SF300	E3 UBIQUITIN-PROTEIN LIGASE SMURF2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	LEIMA|EnsemblGenome=LmjF.18.1080|UniProtKB=Q27687	Protein kinase A catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DANRE|ZFIN=ZDB-GENE-040718-134|UniProtKB=Q6DH55	Guanine nucleotide binding protein (G protein), beta polypeptide 3, like	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	RCA	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	IC	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00029	Huntington disease	P00807	Actin	DICDI|dictyBase=DDB_G0289487|UniProtKB=P07829	Actin-3	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00021	FGF signaling pathway	P00635	FRS2	HUMAN|HGNC=16970|UniProtKB=O43559	Fibroblast growth factor receptor substrate 3	IPI			PTHR21258:SF39	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	CANLF|Ensembl=ENSCAFG00000023094|UniProtKB=Q076A8	Developmental myosin heavy chain embryonic	ISS	89264452	PubMed	PTHR13140:SF427	MYOSIN-3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00896	Insulin IGF	XENTR|Xenbase=XB-GENE-485905|UniProtKB=A4IGV9	Ins protein	ISS			PTHR11454:SF9	INSULIN-RELATED
P00021	FGF signaling pathway	P00627	ERK1-2	ORYSJ|EnsemblGenome=OS06G0154500|UniProtKB=Q84UI5	Mitogen-activated protein kinase 1	ISS			PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P00020	FAS signaling pathway	P00615	JNK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00018	EGF receptor signaling pathway	P00558	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00055	Transcription regulation by bZIP transcription factor	P01396	TFIIFbeta	PANTR|Ensembl=ENSPTRG00000005840|UniProtKB=H2R032	General transcription factor IIF subunit 2	ISS			PTHR10445:SF0	GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	IDA	15528206	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01148	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	8479536	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	CAEEL|WormBase=WBGene00001985|UniProtKB=O02100	Presenilin hop-1	TAS	8755489	PubMed	PTHR10202:SF14	PRESENILIN HOP-1
P02738	De novo purine biosynthesis	P02904	Guanylate kinase	CHLTR|EnsemblGenome=CT_030|UniProtKB=O84033	Guanylate kinase	ISS			PTHR23117:SF13	GUANYLATE KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	HUMAN|HGNC=4336|UniProtKB=P49448	Glutamate dehydrogenase 2, mitochondrial	ISS			PTHR11606:SF15	GLUTAMATE DEHYDROGENASE 2, MITOCHONDRIAL
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00048	PI3 kinase pathway	P01179	PKB	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	22081553	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01292	RSmads	CANLF|Ensembl=ENSCAFG00000001094|UniProtKB=E2RCX7	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF36	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00790	beta-Tubulin	PHYPA|Gene=PHYPADRAFT_232451|UniProtKB=A9SKU2	Predicted protein	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00018	EGF receptor signaling pathway	P00551	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IGI	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	HUMAN|HGNC=17306|UniProtKB=Q9HBM6	Transcription initiation factor TFIID subunit 9B	ISS			PTHR12595:SF3	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 9B
P00029	Huntington disease	P00790	beta-Tubulin	DROME|FlyBase=FBgn0003888|UniProtKB=P08841	Tubulin beta-3 chain	TAS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04393	Ras Pathway	P04559	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	MONDO|Ensembl=ENSMODG00000012050|UniProtKB=F7ALE8	Uncharacterized protein	ISS	9362521	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P04393	Ras Pathway	P04547	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000003043|UniProtKB=P63212	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00010	B cell activation	P00379	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00048	PI3 kinase pathway	P01192	p110	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	MACMU|Ensembl=ENSMMUG00000014817|UniProtKB=F6VXD8	Uncharacterized protein	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00057	Wnt signaling pathway	P01452	NFAT	MOUSE|MGI=MGI=103296|UniProtKB=P97305	Nuclear factor of activated T-cells, cytoplasmic 3	IDA	9133421	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	HUMAN|HGNC=5299|UniProtKB=Q13639	5-hydroxytryptamine receptor 4	IDA	12441358	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00924	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	IPI	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04396	Vitamin D metabolism and pathway	P04601	25-Hydroxylase	PANTR|Ensembl=ENSPTRG00000005149|UniProtKB=H2Q6C4	Uncharacterized protein	ISS	11013342	PubMed	PTHR24291:SF3	25-HYDROXYVITAMIN D-1 ALPHA HYDROXYLASE, MITOCHONDRIAL
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	ISS	10799299	PubMed	PTHR10048:SF14	PI-3 KINASE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	XENTR|Xenbase=XB-GENE-923233|UniProtKB=Q6AZK9	Nucleoside diphosphate kinase	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P00019	Endothelin signaling pathway	P00568	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00254	GTPase	HUMAN|HGNC=667|UniProtKB=P61586	Transforming protein RhoA	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	RAT|RGD=620023|UniProtKB=P10980	Muscarinic acetylcholine receptor M2	TAS	10069496	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	HUMAN|HGNC=9855|UniProtKB=P62834	Ras-related protein Rap-1A	IDA	1904317	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	DICDI|dictyBase=DDB_G0277143|UniProtKB=P36408	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P05918	p38 MAPK pathway	P06029	p38beta	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	RCA	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00021	FGF signaling pathway	P00629	PP2A	ORYSJ|EnsemblGenome=OS01G0691700|UniProtKB=Q8RZZ3	Serine/threonine-protein phosphatase	ISS			PTHR11668:SF24	SERINE/THREONINE-PROTEIN PHOSPHATASE 6 CATALYTIC SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	CANLF|Ensembl=ENSCAFG00000019633|UniProtKB=F1PDC7	Uncharacterized protein	ISS	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00001	Adrenaline and noradrenaline biosynthesis	P00068	amine translocator	MOUSE|MGI=MGI=1336891|UniProtKB=O88575	Sodium- and chloride-dependent transporter XTRP3B	IC	12719981	PubMed	PTHR11616:SF44	SODIUM- AND CHLORIDE-DEPENDENT TRANSPORTER XTRP3
P05912	Dopamine receptor mediated signaling pathway	P05963	MAO	CANLF|Gene=MAOB|UniProtKB=Q7YRB7	Amine oxidase [flavin-containing] B	ISS	8602220	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P00021	FGF signaling pathway	P00645	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	10891487	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00055	Transcription regulation by bZIP transcription factor	P01392	TFIIH complex	SCHPO|PomBase=SPBC13G1.13|UniProtKB=P87303	RNA polymerase II transcription factor B subunit 2	ISS			PTHR13152:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00029	Huntington disease	P00788	Calpain	CAEEL|WormBase=WBGene00000543|UniProtKB=Q22143	CaLPain family	IDA	11675509	PubMed	PTHR10183:SF22	CALPAIN-7
P00029	Huntington disease	P00805	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IDA	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000004389|UniProtKB=F7FMS7	Cadherin-14	ISS	8120095	PubMed	PTHR24027:SF106	CADHERIN-18
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IDA	7492337	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00018	EGF receptor signaling pathway	P00539	14-3-3	CAEBR|Gene=CBG06174|UniProtKB=A8X0R4	Protein CBR-PAR-5	ISS	22318813	PubMed	PTHR18860:SF21	14-3-3-LIKE PROTEIN 1
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00029	Huntington disease	P00774	Dynein complex	XENTR|Xenbase=XB-GENE-960812|UniProtKB=F7BCN5	Uncharacterized protein	ISS	9454836	PubMed	PTHR12442:SF22	CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN 2
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	20331588	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04397	p53 pathway by glucose deprivation	P04641	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00047	PDGF signaling pathway	P01153	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00056	VEGF signaling pathway	P01413	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	7937853	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00029	Huntington disease	P00807	Actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	ISS	10974003	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	IGI	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008422|UniProtKB=F6VUT7	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MOUSE|MGI=MGI=87904|UniProtKB=P60710	Actin, cytoplasmic 1	IC	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00018	EGF receptor signaling pathway	P00539	14-3-3	ASHGO|EnsemblGenome=AGOS_AGR107C|UniProtKB=Q74ZU1	AGR107Cp	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00046	Oxidative stress response	P01135	p38	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	TAS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00037	Ionotropic glutamate receptor pathway	P01026	KA	PANTR|Ensembl=ENSPTRG00000013825|UniProtKB=H2RAK4	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	MACMU|Ensembl=ENSMMUG00000010184|UniProtKB=F6SR09	Uncharacterized protein	ISS	7476890	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	XENTR|Xenbase=XB-GENE-957248|UniProtKB=Q6GLE6	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00004	Alzheimer disease-presenilin pathway	P00162	Pro-BACE-1	MONDO|Ensembl=ENSMODG00000013692|UniProtKB=F6QP52	Uncharacterized protein	ISS	10531052	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	ORNAN|Ensembl=ENSOANG00000004342|UniProtKB=F6S3B9	Uncharacterized protein	ISS	12181435	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00049	Parkinson disease	P01238	14-3-3	CHICK|Ensembl=ENSGALG00000006743|UniProtKB=Q5ZKJ2	Uncharacterized protein	ISS	14593000	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00036	Interleukin signaling pathway	P00990	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	CANLF|Ensembl=ENSCAFG00000019633|UniProtKB=F1PDC7	Uncharacterized protein	ISS	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00006	Apoptosis signaling pathway	P00313	IKK	RAT|RGD=621375|UniProtKB=Q9QY78	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	HUMAN|HGNC=13800|UniProtKB=Q9GZZ6	Neuronal acetylcholine receptor subunit alpha-10	IC			PTHR18945:SF768	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-10
P00036	Interleukin signaling pathway	P00983	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02781	Threonine biosynthesis	P03190	Threonine synthase	PYRAE|EnsemblGenome=PAE2878|UniProtKB=Q8ZUA2	Threonine synthase	ISS			PTHR10314:SF5	THREONINE SYNTHASE 1, CHLOROPLASTIC
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	HUMAN|HGNC=9995|UniProtKB=O14921	Regulator of G-protein signaling 13	IDA	12193720	PubMed	PTHR10845:SF32	REGULATOR OF G-PROTEIN SIGNALING 13
P00060	Ubiquitin proteasome pathway	P01494	19S proteasome	DICDI|dictyBase=DDB_G0289003|UniProtKB=P34123	26S protease regulatory subunit 6B homolog	ISS			PTHR23073:SF8	26S PROTEASE REGULATORY SUBUNIT 6B
P00010	B cell activation	P00371	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CIOIN|Ensembl=ENSCING00000007153|UniProtKB=L7N0T1	Uncharacterized protein	ISS			PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	IC	12488551	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P04392	P53 pathway feedback loops 1	P04539	p53	CANLF|Ensembl=ENSCAFG00000013961|UniProtKB=F1PL57	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00020	FAS signaling pathway	P00612	Fas	BOVIN|Ensembl=ENSBTAG00000010785|UniProtKB=P51867	Tumor necrosis factor receptor superfamily member 6	ISS	14585074	PubMed	PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	HUMAN|HGNC=7884|UniProtKB=Q99466	Neurogenic locus notch homolog protein 4	IDA	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	G06045	preproenkephalin	DANRE|ZFIN=ZDB-GENE-030729-31|UniProtKB=A8E7S2	Uncharacterized protein	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00021	FGF signaling pathway	P00632	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01306	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00002	Alpha adrenergic receptor signaling pathway	P00078	Alpha1A/1B/1C	RAT|RGD=62064|UniProtKB=P23944	Alpha-1D adrenergic receptor	IC	6323229	PubMed	PTHR24248:SF14	ALPHA-1D ADRENERGIC RECEPTOR
P00054	Toll receptor signaling pathway	P01368	MKK2	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	PANTR|Ensembl=ENSPTRG00000012514|UniProtKB=H2QIT0	Serine/threonine-protein kinase receptor	ISS	9395284	PubMed	PTHR23255:SF64	ACTIVIN RECEPTOR TYPE-2A
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01448	CBP	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	BOVIN|Ensembl=ENSBTAG00000003054|UniProtKB=F1MC23	Tyrosine-protein kinase receptor	ISS	11182407	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT5G19010|UniProtKB=Q8W4J2	Mitogen-activated protein kinase 16	IDA			PTHR24055:SF211	MITOGEN-ACTIVATED PROTEIN KINASE 16
P00048	PI3 kinase pathway	P01189	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	TAS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=13733|UniProtKB=Q9H251	Cadherin-23	IDA	8120095	PubMed	PTHR43956:SF3	CADHERIN-23
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	CANLF|Ensembl=ENSCAFG00000013324|UniProtKB=F1PCS0	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	LEIMA|EnsemblGenome=LmjF.35.3960|UniProtKB=E9AFM1	Protein kinase A catalytic subunit isoform 2	ISS	10553940	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00219	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04393	Ras Pathway	P04570	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	IC	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CHICK|Gene=CHRM4|UniProtKB=P17200	Muscarinic acetylcholine receptor M4	IDA			PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	HUMAN|HGNC=784|UniProtKB=P15336	Cyclic AMP-dependent transcription factor ATF-2	TAS	10487205	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P04393	Ras Pathway	P04578	Rho	CANLF|Gene=RHOA|UniProtKB=P24406	Transforming protein RhoA	ISS	10556059	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00048	PI3 kinase pathway	P01200	SHIP	PANTR|Ensembl=ENSPTRG00000003079|UniProtKB=H2R3J5	Inositol polyphosphate-5-phosphatase, 40kDa	ISS			PTHR12997:SF2	TYPE I INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00020	FAS signaling pathway	P00620	CytochromeC	PANTR|Ensembl=ENSPTRG00000020679|UniProtKB=H2QWV8	Cytochrome c-1	ISS	9027315	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00035	Interferon-gamma signaling pathway	P00952	Jak2	RAT|RGD=2939|UniProtKB=Q62689	Tyrosine-protein kinase JAK2	TAS	22482294	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00029	Huntington disease	P00777	CBP	BOVIN|Ensembl=ENSBTAG00000016198|UniProtKB=E1B8D6	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P04398	p53 pathway feedback loops 2	P04658	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00048	PI3 kinase pathway	P01199	Galpha	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IC	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	MOUSE|MGI=MGI=97402|UniProtKB=P00860	Ornithine decarboxylase	ISS			PTHR11482:SF42	ORNITHINE DECARBOXYLASE
P00021	FGF signaling pathway	P00632	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IDA	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00029	Huntington disease	P00802	PACSIN-1	BOVIN|Ensembl=ENSBTAG00000016124|UniProtKB=A7MBI0	Protein kinase C and casein kinase substrate in neurons protein 1	ISS	12354780	PubMed	PTHR23065:SF16	PROTEIN KINASE C AND CASEIN KINASE SUBSTRATE IN NEURONS PROTEIN 1
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	CHICK|Gene=KCNJ3|UniProtKB=Q90854	G protein-activated inward rectifier potassium channel 1	ISS	2433589	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00048	PI3 kinase pathway	P01192	p110	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04633	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00060	Ubiquitin proteasome pathway	P01490	E3	SCHPO|PomBase=SPAC1805.15c|UniProtKB=Q9UTG2	E3 ubiquitin-protein ligase pub2	ISS			PTHR11254:SF67	E3 UBIQUITIN-PROTEIN LIGASE NEDD-4
P04398	p53 pathway feedback loops 2	P04657	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00021	FGF signaling pathway	P00643	Raf-1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IGI	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00927	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00038	JAK/STAT signaling pathway	P01031	PIAS	MOUSE|MGI=MGI=1913125|UniProtKB=O88907	E3 SUMO-protein ligase PIAS1	ISS	8682149	PubMed	PTHR10782:SF11	E3 SUMO-PROTEIN LIGASE PIAS1
P04395	Vasopressin synthesis	P04593	Glycopeptide	PANTR|Ensembl=ENSPTRG00000013189|UniProtKB=H2QJV1	Uncharacterized protein	ISS	1706187	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04395	Vasopressin synthesis	P04589	Signal Peptidase	CANLF|Ensembl=ENSCAFG00000032663|UniProtKB=Q28250	Signal peptidase complex subunit 2	ISS	2092035	PubMed	PTHR13085:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 2
P00025	Hedgehog signaling pathway	P00692	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00056	VEGF signaling pathway	P01418	Paxillin	DICDI|dictyBase=DDB_G0284863|UniProtKB=Q54NW4	LIM domain-containing protein B	ISS			PTHR24216:SF32	LIM DOMAIN-CONTAINING PROTEIN B
P00047	PDGF signaling pathway	P01145	c-fos	PANTR|Ensembl=ENSPTRG00000006553|UniProtKB=A5A6H0	C-fos	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	XENTR|Xenbase=XB-GENE-6259095|UniProtKB=Q5BL39	Tubulin, beta 2	ISS	12932731	PubMed	PTHR11588:SF93	SUBFAMILY NOT NAMED
P05731	GABA-B receptor II signaling	P05754	Ggamma	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00048	PI3 kinase pathway	P01182	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01179	PKB	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00010	B cell activation	P00398	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00019	Endothelin signaling pathway	P00572	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	RAT|RGD=2738|UniProtKB=Q00960	Glutamate receptor ionotropic, NMDA 2B	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P05917	Opioid proopiomelanocortin pathway	P06004	Mu or Delta receptor	PANTR|Ensembl=ENSPTRG00000000440|UniProtKB=H2PYH8	Uncharacterized protein	ISS	12093103	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00003	Alzheimer disease-amyloid secretase pathway	P00091	Aph-1	CAEEL|WormBase=WBGene00000147|UniProtKB=O45876	Gamma-secretase subunit aph-1	IDA	12110170	PubMed	PTHR12889:SF0	GAMMA-SECRETASE SUBUNIT APH-1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00056	VEGF signaling pathway	P01425	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MACMU|Ensembl=ENSMMUG00000018568|UniProtKB=F6YLW2	Uncharacterized protein	ISS	8649450	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	15572354	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	BRAFL|Gene=BRAFLDRAFT_59748|UniProtKB=C3ZEW2	Putative uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF263	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04657	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01185	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00049	Parkinson disease	P01211	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ARATH|TAIR=AT3G22420|UniProtKB=Q8S8Y9	Serine/threonine-protein kinase WNK2	IDA			PTHR13902:SF107	SERINE/THREONINE-PROTEIN KINASE WNK2-RELATED
P00036	Interleukin signaling pathway	P00973	PKB	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MOUSE|MGI=MGI=1202876|UniProtKB=Q9Z1J1	Transcription factor 7-like 1	IEP	9118222	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P04398	p53 pathway feedback loops 2	P04663	Mdm2	RAT|RGD=1309306|UniProtKB=Q5XIN1	Protein Mdm4	ISS			PTHR13844:SF20	PROTEIN MDM4
P00022	General transcription by RNA polymerase I	P00649	TAF-IC	MACMU|Ensembl=ENSMMUG00000012470|UniProtKB=F7G0B2	Uncharacterized protein	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00015	Circadian clock system	G01497	cry	MACMU|Ensembl=ENSMMUG00000002453|UniProtKB=F7HH05	Cryptochrome-2	ISS	10428031	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000017335|UniProtKB=Q5DRC8	Protocadherin beta-6	ISS	8120095	PubMed	PTHR24028:SF104	PROTOCADHERIN BETA-6
P00036	Interleukin signaling pathway	P00990	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01211	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01185	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00056	VEGF signaling pathway	P01418	Paxillin	PANTR|Ensembl=ENSPTRG00000005527|UniProtKB=H2Q704	Paxillin	ISS	7579684	PubMed	PTHR24216:SF11	PAXILLIN
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DICDI|dictyBase=DDB_G0283907|UniProtKB=P34099	cAMP-dependent protein kinase catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00019	Endothelin signaling pathway	P00591	PLCbeta	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00057	Wnt signaling pathway	P01432	Beta-Catenin	XENTR|Xenbase=XB-GENE-487200|UniProtKB=Q28GC2	Catenin (Cadherin associated protein), beta 1, 88kDa	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00005	Angiogenesis	P00220	c-Jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00057	Wnt signaling pathway	P01453	Ebi	DROME|FlyBase=FBgn0263933|UniProtKB=Q95RJ9	F-box-like/WD repeat-containing protein ebi	IDA	11389839	PubMed	PTHR22846:SF2	F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN TBL1X
P00056	VEGF signaling pathway	P01425	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00054	Toll receptor signaling pathway	P01357	MEKK1	MACMU|Ensembl=ENSMMUG00000012387|UniProtKB=F7EB20	Uncharacterized protein	ISS	8940199	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00059	p53 pathway	P04623	CBP	MOUSE|MGI=MGI=1276116|UniProtKB=B2RWS6	Histone acetyltransferase p300	ISS	10664585	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00012	Cadherin signaling pathway	P00470	F-actin	PRIPA|Gene=PPA17339|UniProtKB=H3F5B4	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF352	ACTIN
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05730	Endogenous cannabinoid signaling	P05746	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00591	PLCbeta	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04393	Ras Pathway	P04567	PI3K	XENTR|Xenbase=XB-GENE-6085226|UniProtKB=F6ZM84	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00021	FGF signaling pathway	P00627	ERK1-2	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01154	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00053	T cell activation	P01318	PKC-theta	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	METJA|EnsemblGenome=MJ_1597|UniProtKB=Q58992	Serine hydroxymethyltransferase	ISS			PTHR11680:SF21	SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	CANLF|Ensembl=ENSCAFG00000003333|UniProtKB=F1PWT6	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	10747026	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00019	Endothelin signaling pathway	P00577	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	ISS	1171954	gi	PTHR10048:SF14	PI-3 KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05918	p38 MAPK pathway	P06038	TRAF6	MACMU|Gene=TRAF6|UniProtKB=B6CJY5	TNF receptor-associated factor 6	ISS			PTHR10131:SF111	TNF RECEPTOR-ASSOCIATED FACTOR 6
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00048	PI3 kinase pathway	P01192	p110	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS			PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00029	Huntington disease	P00774	Dynein complex	BOVIN|Gene=DYNC1I2|UniProtKB=Q0III3	Cytoplasmic dynein 1 intermediate chain 2	ISS	9454836	PubMed	PTHR12442:SF22	CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN 2
P00049	Parkinson disease	P01208	Hsp70	ORYSJ|EnsemblGenome=OS03G0710500|UniProtKB=Q53RJ5	DnaK protein	IDA	12150907	PubMed	PTHR19375:SF215	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 37B-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00846	JAK	RAT|RGD=2939|UniProtKB=Q62689	Tyrosine-protein kinase JAK2	ISS	12686512	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04561	SRF	RAT|RGD=1559787|UniProtKB=D3ZHH8	Protein Srf	ISS	8660892	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00036	Interleukin signaling pathway	P00989	Ets	HUMAN|HGNC=11241|UniProtKB=P17947	Transcription factor PU.1	TAS	8970723	PubMed	PTHR11849:SF16	TRANSCRIPTION FACTOR PU.1
P00029	Huntington disease	P00799	JNK-2	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05934	ELK1	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	RCA	11050086	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00053	T cell activation	P01305	Calmodulin	BOVIN|Ensembl=ENSBTAG00000001575|UniProtKB=F1N6C0	Uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF311	CALMODULIN
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00018	EGF receptor signaling pathway	P00547	PP2A	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	TAKRU|Ensembl=ENSTRUG00000016241|UniProtKB=H2UX35	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF305	PROTEIN KINASE C
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	3755548	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IC	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	DROME|FlyBase=FBgn0019947|UniProtKB=O02194	Presenilin homolog	TAS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	ORNAN|Ensembl=ENSOANG00000007391|UniProtKB=F6PQH1	Uncharacterized protein	ISS	96032356	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00019	Endothelin signaling pathway	P00570	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DANRE|ZFIN=ZDB-GENE-050417-267|UniProtKB=F1QUN8	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF263	ACTIN
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	MACMU|Ensembl=ENSMMUG00000015240|UniProtKB=F6VUY3	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00047	PDGF signaling pathway	P01174	Rho	MACMU|Ensembl=ENSMMUG00000020014|UniProtKB=F7GJA5	Uncharacterized protein	ISS			PTHR14166:SF8	SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 3
P00009	Axon guidance mediated by netrin	P00364	cdc42	DROME|FlyBase=FBgn0010341|UniProtKB=P40793	Cdc42 homolog	ISS	12932731	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00003	Alzheimer disease-amyloid secretase pathway	P00108	ADAM10	BOVIN|Ensembl=ENSBTAG00000005481|UniProtKB=Q10741	Disintegrin and metalloproteinase domain-containing protein 10	IDA	12354787	PubMed	PTHR11905:SF4	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 10
P05915	Opioid proenkephalin pathway	P05994	G-protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04651	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IGI	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00037	Ionotropic glutamate receptor pathway	P01015	Glu4	MACMU|Ensembl=ENSMMUG00000010987|UniProtKB=F7GCX9	Uncharacterized protein	ISS	12497607	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	DROME|FlyBase=FBgn0001142|UniProtKB=P20477	Glutamine synthetase 1, mitochondrial	ISS			PTHR20852:SF44	GLUTAMINE SYNTHETASE 1, MITOCHONDRIAL
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	IC	11319238	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00057	Wnt signaling pathway	P01437	TCF	MACMU|Ensembl=ENSMMUG00000020134|UniProtKB=F6U055	Uncharacterized protein	ISS	9118222	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00047	PDGF signaling pathway	P01173	STAT	XENTR|Xenbase=XB-GENE-5913743|UniProtKB=F6T2X3	Signal transducer and activator of transcription	ISS	11472851	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TAKRU|Ensembl=ENSTRUG00000004787|UniProtKB=P53480	Actin, alpha cardiac	IC	11889126	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00053	T cell activation	P01322	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	IGI	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	RAT|RGD=2157|UniProtKB=P29067	Beta-arrestin-2	IDA	12464600	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00029	Huntington disease	P00810	GAPDH	RAT|Ensembl=ENSRNOG00000038610|UniProtKB=E9PTN6	Glyceraldehyde-3-phosphate dehydrogenase	ISS	8612237	PubMed	PTHR10836:SF51	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00005	Angiogenesis	P00249	PAK	PANTR|Ensembl=ENSPTRG00000015787|UniProtKB=H2QP14	Uncharacterized protein	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00029	Huntington disease	P00790	beta-Tubulin	PRIPA|Gene=PPA02894|UniProtKB=H3DZP3	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF120	SUBFAMILY NOT NAMED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00010	B cell activation	P00371	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00274	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CAEBR|Gene=CBG12415|UniProtKB=A8XFD7	Protein CBR-SYX-7	ISS	10321247	PubMed	PTHR19957:SF209	LD23667P
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00035	Interferon-gamma signaling pathway	P00956	SOCS	RAT|RGD=1304632|UniProtKB=D3ZS84	Protein Socs6	ISS	15032587	PubMed	PTHR44562:SF1	SUPPRESSOR OF CYTOKINE SIGNALING 6
P00012	Cadherin signaling pathway	P00474	Wnt	MONDO|Ensembl=ENSMODG00000001196|UniProtKB=F7GH85	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00010	B cell activation	P00396	CD45	PANTR|Ensembl=ENSPTRG00000001817|UniProtKB=H2Q0U9	Uncharacterized protein	ISS	1672451	PubMed	PTHR19134:SF284	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C
P00046	Oxidative stress response	P01136	Elk-1	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	TAS	12660819	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00037	Ionotropic glutamate receptor pathway	P01018	Glu1	CAEEL|WormBase=WBGene00001612|UniProtKB=P34299	Glutamate receptor 1	ISS	10331083	PubMed	PTHR18966:SF297	GLUTAMATE RECEPTOR 1
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00922	Collagen	HUMAN|HGNC=2210|UniProtKB=P05997	Collagen alpha-2(V) chain	IDA	10778855	PubMed	PTHR24023:SF539	COLLAGEN ALPHA-2 V  CHAIN
P00006	Apoptosis signaling pathway	P00314	MKK3	RAT|RGD=1306620|UniProtKB=B1H230	Map2k3 protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00053	T cell activation	P01312	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	XENTR|Xenbase=XB-GENE-491938|UniProtKB=Q6DIV8	Actin, alpha 1, skeletal muscle	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00048	PI3 kinase pathway	P01179	PKB	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02738	De novo purine biosynthesis	P02889	dGDP kinase	METAC|EnsemblGenome=MA_1524|UniProtKB=Q8TQL6	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=1767|UniProtKB=P55286	Cadherin-8	IDA	8120095	PubMed	PTHR24027:SF273	CADHERIN-8
P00005	Angiogenesis	P00254	GTPase	DANRE|ZFIN=ZDB-GENE-040426-2150|UniProtKB=Q6NUX8	Rho-related GTP-binding protein RhoA-A	ISS	11973360	PubMed	PTHR24072:SF260	RHO-RELATED GTP-BINDING PROTEIN RHOA-A-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04544	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00035	Interferon-gamma signaling pathway	P00960	PTP	DANRE|ZFIN=ZDB-GENE-030131-5911|UniProtKB=F1QZU5	Tyrosine-protein phosphatase non-receptor type	ISS	14525967	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00029	Huntington disease	P00807	Actin	XENTR|Xenbase=XB-GENE-6469705|UniProtKB=Q6P8G3	Actin, alpha sarcomeric/skeletal	ISS	11889126	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P00030	Hypoxia response via HIF activation	P00819	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	TAS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00057	Wnt signaling pathway	P01472	Histone deacetylase	DANRE|ZFIN=ZDB-GENE-040426-847|UniProtKB=Q803C3	Histone deacetylase 3	ISS	10485845	PubMed	PTHR10625:SF132	HISTONE DEACETYLASE 3
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00022	General transcription by RNA polymerase I	P00650	TAF-IB	CANLF|Ensembl=ENSCAFG00000001622|UniProtKB=E2RN76	Uncharacterized protein	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	MOUSE|MGI=MGI=2150393|UniProtKB=Q91ZU9	Glutamate receptor ionotropic, NMDA 3B	ISS	11319238	PubMed	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=2685045|UniProtKB=E9QAN8	Protein Pik3c2b	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P02736	Coenzyme A biosynthesis	P02885	Pantothenate kinase	HUMAN|HGNC=8598|UniProtKB=Q8TE04	Pantothenate kinase 1	ISS			PTHR12280:SF23	PANTOTHENATE KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000020887|UniProtKB=F1MP22	Uncharacterized protein	ISS	11976940	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04395	Vasopressin synthesis	P04589	Signal Peptidase	BOVIN|Ensembl=ENSBTAG00000006644|UniProtKB=E1BEI2	Uncharacterized protein	ISS	7788527	PubMed	PTHR13085:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 2
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	CANLF|Ensembl=ENSCAFG00000009967|UniProtKB=F1PGZ2	Muscarinic acetylcholine receptor	ISS	12181435	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95815|UniProtKB=P39087	Glutamate receptor ionotropic, kainate 2	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	RAT|RGD=621705|UniProtKB=Q8VHN2	Glutamate receptor ionotropic, NMDA 3B	IC	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P00050	Plasminogen activating cascade	P01253	Fibrin	RAT|RGD=2603|UniProtKB=P06399	Fibrinogen alpha chain	IEP	87134033	PubMed	PTHR19143:SF232	FIBRINOGEN ALPHA CHAIN
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01192	p110	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00973	PKB	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00520	Rho GAPs	HUMAN|HGNC=677|UniProtKB=P85298	Rho GTPase-activating protein 8	ISS			PTHR23176:SF3	PROTEIN PRR5-ARHGAP8-RELATED
P04393	Ras Pathway	P04574	PLD	MOUSE|MGI=MGI=892877|UniProtKB=P97813	Phospholipase D2	IDA	12615079	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	XENTR|Ensembl=ENSXETG00000021375|UniProtKB=F6T423	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00050	Plasminogen activating cascade	P01246	Plasmin	HUMAN|HGNC=9071|UniProtKB=P00747	Plasminogen	ISS	130317	gi	PTHR24261:SF6	PLASMINOGEN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05923	beta-ARR2	RAT|RGD=2157|UniProtKB=P29067	Beta-arrestin-2	RCA	4757780	gi	PTHR11792:SF20	BETA-ARRESTIN-2
P00006	Apoptosis signaling pathway	P00260	AKT	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	ISS	21291563	gi	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	BOVIN|Ensembl=ENSBTAG00000006844|UniProtKB=E1BJ93	Uncharacterized protein	ISS	11266476	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01171	PLCgamma	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000016815|UniProtKB=F7C9S6	Uncharacterized protein	ISS	12441358	PubMed	PTHR24229:SF52	SOMATOSTATIN RECEPTOR TYPE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00019	Endothelin signaling pathway	P00586	Gq	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00029	Huntington disease	P00807	Actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347742|UniProtKB=E9FZ00	Cytoplasmatic actin	ISS	14684598	PubMed	PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00006	Apoptosis signaling pathway	P00321	HSP70	MONDO|Ensembl=ENSMODG00000015173|UniProtKB=F6XFE0	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF223	HEAT SHOCK 70 KDA PROTEIN 1A-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00004	Alzheimer disease-presenilin pathway	P00163	Erb-B4 C-terminal fragment	PANTR|Ensembl=ENSPTRG00000012883|UniProtKB=H2QJC5	Receptor protein-tyrosine kinase	ISS	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00014	Cholesterol biosynthesis	P00500	Phosphomevalonate kinase	MOUSE|MGI=MGI=1915853|UniProtKB=Q9D1G2	Phosphomevalonate kinase	ISS			PTHR13101:SF1	PHOSPHOMEVALONATE KINASE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MACMU|Ensembl=ENSMMUG00000004904|UniProtKB=F7CJE4	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P06209	ALP23B signaling pathway	P06220	BABO	DROME|FlyBase=FBgn0011300|UniProtKB=A1Z7L8	Receptor protein serine/threonine kinase	IEA	http://flybase.org/reports/FBgn0011300.html	Website	PTHR23255:SF71	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00049	Parkinson disease	P01238	14-3-3	MACMU|Ensembl=ENSMMUG00000006489|UniProtKB=F7EFF6	14-3-3 protein zeta/delta	ISS	12615066	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00045	Notch signaling pathway	P01103	Next	RAT|RGD=3187|UniProtKB=Q07008	Neurogenic locus notch homolog protein 1	IEP	1764995	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	RAT|RGD=708446|UniProtKB=Q9JLY8	Chemokine (C-C motif) receptor 1	ISS	9329966	PubMed	PTHR10489:SF711	C-C CHEMOKINE RECEPTOR TYPE 1
P00048	PI3 kinase pathway	G01545	scl-1	CAEEL|WormBase=WBGene00009896|UniProtKB=G5EF50	SCP-Like extracellular protein	ISS			PTHR10334:SF161	SCP-LIKE EXTRACELLULAR PROTEIN
P00048	PI3 kinase pathway	P01177	P110ACT	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01444	Wnt	PANTR|Ensembl=ENSPTRG00000019627|UniProtKB=H2QVA4	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P00053	T cell activation	P01307	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00036	Interleukin signaling pathway	P00965	ERK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00383	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IDA	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04393	Ras Pathway	P04547	Ras	CHICK|Ensembl=ENSGALG00000006885|UniProtKB=P08642	GTPase HRas	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00050	Plasminogen activating cascade	P01245	PAI-1	PANTR|Ensembl=ENSPTRG00000019519|UniProtKB=H2QV47	Uncharacterized protein	ISS	10692390	PubMed	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02723	Adenine and hypoxanthine salvage pathway	P02809	Xanthine dehydrogenase	CAEEL|WormBase=WBGene00017487|UniProtKB=O61198	Uncharacterized protein	ISS			PTHR11908:SF102	ALDEHYDE OXIDASE GAD-3-RELATED
P00054	Toll receptor signaling pathway	P01358	ERK1	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	P01465	Ggamma	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00010	B cell activation	P00381	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	IGI	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00383	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	CHICK|Gene=ACVR2B|UniProtKB=Q90670	Activin receptor type-2B	TAS	9395284	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	IC	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00060	Ubiquitin proteasome pathway	P01492	E1	MONDO|Ensembl=ENSMODG00000003622|UniProtKB=F7BMV0	Uncharacterized protein	ISS			PTHR10953:SF6	NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00053	T cell activation	P01300	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	DROME|FlyBase=FBgn0000253|UniProtKB=P62152	Calmodulin	ISS	7514101	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000002647|UniProtKB=F7DIB7	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00048	PI3 kinase pathway	P01199	Galpha	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	IC	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00038	JAK/STAT signaling pathway	P01027	STAT	CANLF|Ensembl=ENSCAFG00000015509|UniProtKB=F1PNW8	Signal transducer and activator of transcription	ISS	96210005	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00046	Oxidative stress response	P01135	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00056	VEGF signaling pathway	P01407	Erk	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9836512	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT3G59790|UniProtKB=Q9M1Z5	Mitogen-activated protein kinase 10	ISS	12787066	PubMed	PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	DANRE|ZFIN=ZDB-GENE-030131-9662|UniProtKB=Q6TEN1	Ras-related protein Rap-1b	ISS	10476970	PubMed	PTHR24070:SF382	RAS-RELATED PROTEIN RAP-1B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	HUMAN|HGNC=7578|UniProtKB=P13535	Myosin-8	ISS	10938134	PubMed	PTHR13140:SF368	MYOSIN-8
P05730	Endogenous cannabinoid signaling	P05746	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IPI	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00036	Interleukin signaling pathway	P00973	PKB	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00560	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00572	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IGI	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00047	PDGF signaling pathway	P01143	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04567	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00025	Hedgehog signaling pathway	P00692	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MOUSE|MGI=MGI=894644|UniProtKB=Q8CC27	Voltage-dependent L-type calcium channel subunit beta-2	IC	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01095	beta	CAEEL|WormBase=WBGene00006765|UniProtKB=P48181	Acetylcholine receptor subunit beta-type unc-29	ISS	22213672	PubMed	PTHR18945:SF471	ACETYLCHOLINE RECEPTOR SUBUNIT BETA-TYPE UNC-29
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	BOVIN|Ensembl=ENSBTAG00000014828|UniProtKB=F1N1E0	Uncharacterized protein	ISS	8386525	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IC	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04393	Ras Pathway	P04578	Rho	XENTR|Xenbase=XB-GENE-941426|UniProtKB=Q28HZ4	Novel Rho protein	ISS	12024019	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P04397	p53 pathway by glucose deprivation	P04641	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DANRE|ZFIN=ZDB-GENE-070705-74|UniProtKB=B8A569	Uncharacterized protein	IEP	10938134	PubMed	PTHR13140:SF676	MYOSIN, HEAVY POLYPEPTIDE 2, FAST MUSCLE SPECIFIC
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	CANLF|Ensembl=ENSCAFG00000009203|UniProtKB=F1PVZ1	Muscarinic acetylcholine receptor	ISS	11166329	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00474	Wnt	DANRE|ZFIN=ZDB-GENE-001106-1|UniProtKB=F1QK98	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P00029	Huntington disease	P00775	Rac	RAT|RGD=621310|UniProtKB=Q32PX6	Protein Rhog	ISS	12932731	PubMed	PTHR24072:SF158	RHO-RELATED GTP-BINDING PROTEIN RHOG
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	LEPIN|EnsemblGenome=LA_1929|UniProtKB=Q8CXT1	CAP family transcription factor	IC	88234494	PubMed	PTHR45452:SF1	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_127489|UniProtKB=C3XYC6	Putative uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00020	FAS signaling pathway	P00595	Caspase7	HUMAN|HGNC=1508|UniProtKB=P55210	Caspase-7	IGI	14583630	PubMed	PTHR10454:SF31	CASPASE-7
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	RAT|RGD=2747|UniProtKB=P35349	Metabotropic glutamate receptor 6	ISS	11431030	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00005	Angiogenesis	P00243	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P06664	Gonadotropin-releasing hormone receptor pathway	P06794	MAP2K1/2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	RCA	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00011	Blood coagulation	P00416	Prothrombin	HUMAN|HGNC=3535|UniProtKB=P00734	Prothrombin	ISS	4503635	gi	PTHR24254:SF10	PROTHROMBIN
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00046	Oxidative stress response	P01129	JNK1/2	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00006	Apoptosis signaling pathway	P00260	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IGI	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00057	Wnt signaling pathway	P01471	alpha-catenin	DANRE|Ensembl=ENSDARG00000024785|UniProtKB=B7ZC77	Catenin alpha-2	ISS	1768802	PubMed	PTHR18914:SF29	CATENIN ALPHA-2
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MACMU|Ensembl=ENSMMUG00000002439|UniProtKB=F6PJN8	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P00010	B cell activation	P00371	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_60743|UniProtKB=C3XYD4	Putative uncharacterized protein	ISS			PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00238	Ras	DANRE|ZFIN=ZDB-GENE-990415-166|UniProtKB=P79737	GTPase NRas	ISS	9116869	PubMed	PTHR24070:SF189	GTPASE NRAS
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	PANTR|Ensembl=ENSPTRG00000022187|UniProtKB=Q7YQL4	Serine/threonine-protein kinase PAK 3	ISS	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04393	Ras Pathway	P04569	Cdc42	DANRE|ZFIN=ZDB-GENE-030131-6069|UniProtKB=Q7ZUQ1	Cdc42l protein	ISS			PTHR24072:SF129	CDC42L PROTEIN
P00053	T cell activation	P01332	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04557	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	IDA	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00005	Angiogenesis	P00187	beta catenin	CHICK|Ensembl=ENSGALG00000011905|UniProtKB=F1NHT7	Uncharacterized protein	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P05915	Opioid proenkephalin pathway	P05994	G-protein	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00546	GAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	2574500	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01435	SWI/SNF	MACMU|Ensembl=ENSMMUG00000012697|UniProtKB=F7DX53	Uncharacterized protein	ISS	11532957	PubMed	PTHR12656:SF12	AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 1A
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	HUMAN|HGNC=5467|UniProtKB=P11717	Cation-independent mannose-6-phosphate receptor	TAS	11081635	PubMed	PTHR15071:SF17	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
P00056	VEGF signaling pathway	P01411	Ras	MONDO|Ensembl=ENSMODG00000025248|UniProtKB=F7F5X1	Uncharacterized protein	ISS	99084794	PubMed	PTHR24070:SF186	GTPASE KRAS
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT1G10210|UniProtKB=Q39021	Mitogen-activated protein kinase 1	ISS	176948	OMIM	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MOUSE|MGI=MGI=87909|UniProtKB=P62737	Actin, aortic smooth muscle	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00011	Blood coagulation	P00425	ZPI	HUMAN|HGNC=15996|UniProtKB=Q9UK55	Protein Z-dependent protease inhibitor	ISS	7705879	gi	PTHR11461:SF191	PROTEIN Z-DEPENDENT PROTEASE INHIBITOR
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00020	FAS signaling pathway	P00610	MKK4	CHICK|Ensembl=ENSGALG00000001001|UniProtKB=F1P3T1	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01438	PP2A	CANLF|Ensembl=ENSCAFG00000001753|UniProtKB=F1P714	Uncharacterized protein	ISS	12110603	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01332	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IDA	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01407	Erk	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00562	p38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IGI	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00044	Nicotinic acetylcholine receptor signaling pathway	P01095	beta	MOUSE|MGI=MGI=87890|UniProtKB=P09690	Acetylcholine receptor subunit beta	ISS	22213672	PubMed	PTHR18945:SF477	ACETYLCHOLINE RECEPTOR SUBUNIT BETA
P00020	FAS signaling pathway	P00615	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00564	Rac	DICDI|dictyBase=DDB_G0282365|UniProtKB=P34146	Rho-related protein rac1C	IGI	94124042	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00053	T cell activation	P01307	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	XENTR|Xenbase=XB-GENE-480347|UniProtKB=Q6P640	Actin, alpha cardiac muscle 1	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04580	TRH Receptor	MACMU|Ensembl=ENSMMUG00000008734|UniProtKB=F7DWM0	Thyrotropin-releasing hormone receptor	ISS	7509436	PubMed	PTHR24243:SF115	THYROTROPIN-RELEASING HORMONE RECEPTOR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	IDA	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P05915	Opioid proenkephalin pathway	P05989	leu-Enkephalin	XENTR|Xenbase=XB-GENE-942760|UniProtKB=F6Y5F6	Uncharacterized protein	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P05730	Endogenous cannabinoid signaling	P05751	Galpha	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00036	Interleukin signaling pathway	P00973	PKB	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MOUSE|MGI=MGI=87906|UniProtKB=P63260	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	RCA	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04569	Cdc42	DROME|FlyBase=FBgn0010341|UniProtKB=P40793	Cdc42 homolog	ISS	12932731	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00049	Parkinson disease	P01219	SAPK	EMENI|EnsemblGenome=CADANIAG00001630|UniProtKB=Q9P419	Mitogen-activated protein kinase hog1	NAS			PTHR24055:SF247	MITOGEN-ACTIVATED PROTEIN KINASE HOG1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	MOUSE|MGI=MGI=2684334|UniProtKB=Q70UZ7	von Willebrand factor A domain-containing protein 2	IC	10778855	PubMed	PTHR44880:SF1	VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 2
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00038	JAK/STAT signaling pathway	P01027	STAT	CANLF|Ensembl=ENSCAFG00000015509|UniProtKB=F1PNW8	Signal transducer and activator of transcription	ISS	22320921	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05913	Enkephalin release	P05972	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	RCA	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00907	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02783	Tryptophan biosynthesis	P03208	Tryptophan synthase B	THEMA|EnsemblGenome=TM_0539|UniProtKB=Q9WZ09	Tryptophan synthase beta chain 2	ISS			PTHR43565:SF1	TRYPTOPHAN SYNTHASE BETA CHAIN
P00009	Axon guidance mediated by netrin	P00363	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00021	FGF signaling pathway	P00642	MEK1-2	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	DROME|FlyBase=FBgn0038837|UniProtKB=Q9VDH5	CG3822	IC	12941441	PubMed	PTHR18966:SF352	GLUTAMATE RECEPTOR FAMILY  AMPA
P00036	Interleukin signaling pathway	P00981	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	MOUSE|MGI=MGI=96434|UniProtKB=P09535	Insulin-like growth factor II	ISS	4504609	gi	PTHR11454:SF10	INSULIN-LIKE GROWTH FACTOR II
P00059	p53 pathway	P04609	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	HUMAN|HGNC=1388|UniProtKB=O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	14507926	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	ARATH|TAIR=AT1G73660|UniProtKB=Q9C9U5	MAPKKK-like kinase	ISS			PTHR44741:SF2	MAPKKK-LIKE KINASE-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=1310389|UniProtKB=D3ZTF6	Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Predicted), isoform CRA_a	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	XENTR|Xenbase=XB-GENE-493937|UniProtKB=Q5M8T9	Actin, alpha 2, smooth muscle, aorta	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05918	p38 MAPK pathway	P06029	p38beta	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P02749	Leucine biosynthesis	P03000	Branched chain amino acid aminotransferase	DEIRA|EnsemblGenome=DR_1626|UniProtKB=Q9RTX5	Branched-chain-amino-acid aminotransferase	ISS			PTHR42825:SF2	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 3, CHLOROPLASTIC
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-478663|UniProtKB=F7EG64	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P06215	MYO signaling pathway	P06311	MED	DROME|FlyBase=FBgn0011655|UniProtKB=O62609	Mothers against decapentaplegic homolog	IEA	9395284	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	9395335	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	MACMU|Ensembl=ENSMMUG00000018272|UniProtKB=F7HEB8	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	BOVIN|Ensembl=ENSBTAG00000019210|UniProtKB=F1MJV4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00018	EGF receptor signaling pathway	P00556	PLCgamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IGI	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	ISS	11256888	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00006	Apoptosis signaling pathway	P00321	HSP70	RAT|RGD=2843|UniProtKB=P06761	78 kDa glucose-regulated protein	ISS	10934466	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	SCHPO|PomBase=SPAC9E9.09c|UniProtKB=O14293	Putative aldehyde dehydrogenase-like protein C9E9.09c	IC			PTHR11699:SF211	ALDEHYDE DEHYDROGENASE 5, MITOCHONDRIAL
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00045	Notch signaling pathway	P01110	Presenilin	BOVIN|Ensembl=ENSBTAG00000011757|UniProtKB=Q9XT97	Presenilin-1	ISS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00034	Integrin signalling pathway	P00916	Ras	BOVIN|Ensembl=ENSBTAG00000020983|UniProtKB=Q2TBH2	Related RAS viral (R-ras) oncogene homolog	ISS	7997267	PubMed	PTHR24070:SF245	RAS-RELATED PROTEIN R-RAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00729	Goalpha	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00547	PP2A	BOVIN|Ensembl=ENSBTAG00000000469|UniProtKB=P67774	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	CANLF|Ensembl=ENSCAFG00000015662|UniProtKB=E2RHY4	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00018	EGF receptor signaling pathway	P00557	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IGI	129387	gi	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	MACMU|Ensembl=ENSMMUG00000019999|UniProtKB=F7FNE2	Uncharacterized protein	ISS	12135927	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00049	Parkinson disease	P01238	14-3-3	MACMU|Ensembl=ENSMMUG00000006489|UniProtKB=F7EFF6	14-3-3 protein zeta/delta	ISS	92283271	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00927	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01443	Phospholipase C	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00052	TGF-beta signaling pathway	P01276	Co-Smads	PANTR|Ensembl=ENSPTRG00000010028|UniProtKB=H2QEJ6	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P00021	FGF signaling pathway	P00648	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IGI	10395542	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	RAT|RGD=71083|UniProtKB=P30940	5-hydroxytryptamine receptor 1F	ISS	1608964	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00011	Blood coagulation	P00408	Plasminogen	RAT|RGD=619893|UniProtKB=Q01177	Plasminogen	ISS	11928811	PubMed	PTHR24261:SF5	PLASMINOGEN
P00004	Alzheimer disease-presenilin pathway	P00172	BACE-1	HUMAN|HGNC=934|UniProtKB=Q9Y5Z0	Beta-secretase 2	IDA			PTHR13683:SF262	BETA-SECRETASE 2
P02723	Adenine and hypoxanthine salvage pathway	P02810	Adenine phosphoribosyl transferase	YEAST|SGD=S000004484|UniProtKB=P49435	Adenine phosphoribosyltransferase 1	ISS			PTHR32315:SF3	ADENINE PHOSPHORIBOSYLTRANSFERASE
P04393	Ras Pathway	P04566	Stat 1/3	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	14755057	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00029	Huntington disease	P00786	ARF	BOVIN|Ensembl=ENSBTAG00000006785|UniProtKB=P84081	ADP-ribosylation factor 2	ISS	12932731	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00057	Wnt signaling pathway	P01465	Ggamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P06664	Gonadotropin-releasing hormone receptor pathway	P06825	IRS-1	MOUSE|MGI=MGI=99454|UniProtKB=P35569	Insulin receptor substrate 1	RCA	11701440	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00010	B cell activation	P00373	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00025	Hedgehog signaling pathway	P00682	PKA	STRPU|EnsemblGenome=SPU_018419|UniProtKB=W4YRI6	Uncharacterized protein	ISS	97210759	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	15621031	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00046	Oxidative stress response	P01128	MEF-2	BOVIN|Ensembl=ENSBTAG00000010649|UniProtKB=A2VDZ3	Myocyte-specific enhancer factor 2A	ISS	11274345	PubMed	PTHR11945:SF256	MYOCYTE-SPECIFIC ENHANCER FACTOR 2A
P00053	T cell activation	P01305	Calmodulin	HUMAN|HGNC=1442|UniProtKB=P62158	Calmodulin	IDA	7514101	PubMed	PTHR23050:SF311	CALMODULIN
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MACMU|Ensembl=ENSMMUG00000001789|UniProtKB=F7GIU0	5-hydroxytryptamine receptor 1A	ISS			PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	DROME|FlyBase=FBgn0065032|UniProtKB=Q9VX82	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04395	Vasopressin synthesis	P04597	Signal Peptide	PANTR|Ensembl=ENSPTRG00000013189|UniProtKB=H2QJV1	Uncharacterized protein	ISS	1706187	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00057	Wnt signaling pathway	P01440	Cadherin	MONDO|Ensembl=ENSMODG00000007312|UniProtKB=F7EXZ6	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF273	CADHERIN-8
P00005	Angiogenesis	P00219	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	2372396	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	MONDO|Ensembl=ENSMODG00000025188|UniProtKB=F7C1G3	Uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00053	T cell activation	P01322	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	IGI	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000007445|UniProtKB=F6SWI4	Uncharacterized protein	ISS	20088160	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ORNAN|Ensembl=ENSOANG00000007581|UniProtKB=F6QWB7	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	STRCO|EnsemblGenome=CAB90845|UniProtKB=P15106	Glutamine synthetase	ISS			PTHR43407:SF1	LENGSIN
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02766	Phenylethylamine degradation	P03103	Phenylethylamine oxidase	MOUSE|MGI=MGI=1306797|UniProtKB=O70423	Membrane primary amine oxidase	ISS			PTHR10638:SF23	MEMBRANE PRIMARY AMINE OXIDASE
P00023	General transcription regulation	P00660	RNA Polymerase II	CHICK|Ensembl=ENSGALG00000001168|UniProtKB=E1BV97	Uncharacterized protein	ISS	2187864	PubMed	PTHR11800:SF2	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3
P04393	Ras Pathway	P04543	MEKK1/4	MOUSE|MGI=MGI=1346875|UniProtKB=O08648	Mitogen-activated protein kinase kinase kinase 4	IDA	97236778	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00015	Circadian clock system	P00505	Cry	BOVIN|Ensembl=ENSBTAG00000010149|UniProtKB=F1MXB2	Uncharacterized protein	ISS	10428031	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00054	Toll receptor signaling pathway	P01381	Ubc13	MONDO|Ensembl=ENSMODG00000009451|UniProtKB=F7FZL4	Uncharacterized protein	ISS			PTHR43902:SF2	UBIQUITIN-CONJUGATING ENZYME E2 N
P04398	p53 pathway feedback loops 2	P04665	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00705	Gsalpha	MACMU|Ensembl=ENSMMUG00000010266|UniProtKB=F6PV18	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00005	Angiogenesis	P00219	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	CANLF|Ensembl=ENSCAFG00000028654|UniProtKB=J9P702	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00021	FGF signaling pathway	P00634	MEKK1-5	PANTR|Ensembl=ENSPTRG00000000404|UniProtKB=H2PYF3	Mitogen-activated protein kinase kinase kinase 6	ISS	9875215	PubMed	PTHR11584:SF391	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00046	Oxidative stress response	P01135	p38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P02738	De novo purine biosynthesis	P02902	ADP reductase	PLAF7|EnsemblGenome=PF14_0352|UniProtKB=Q8IL94	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P02779	Thiamin biosynthesis	P03170	Hydroxymethylpyrimidine phosphate kinase	NEUCR|Gene=NCU07849|UniProtKB=U9W4I4	Thiamine-4	ISS			PTHR20858:SF17	HYDROXYMETHYLPYRIMIDINE/PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED
P00047	PDGF signaling pathway	P01159	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00059	p53 pathway	P01486	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	MOUSE|MGI=MGI=88296|UniProtKB=O55017	Voltage-dependent N-type calcium channel subunit alpha-1B	IDA	14624853	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00021	FGF signaling pathway	P00627	ERK1-2	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00636	FGFR1-4	BOVIN|Ensembl=ENSBTAG00000015457|UniProtKB=A4IFL5	Fibroblast growth factor receptor	ISS	1708247	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P00005	Angiogenesis	P00217	STAT3	MONDO|Ensembl=ENSMODG00000028212|UniProtKB=F7BYN4	Signal transducer and activator of transcription	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01423	p38MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	PANTR|Ensembl=ENSPTRG00000013893|UniProtKB=H2PZY5	Uncharacterized protein	ISS	11827521	PubMed	PTHR10223:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_206575|UniProtKB=E9FUX0	Guanine nucleotide binding protein, beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00552	Ras	DICDI|dictyBase=DDB_G0281385|UniProtKB=P32253	Ras-like protein rasC	IGI	8290260	PubMed	PTHR24070:SF251	RAS-LIKE PROTEIN RASC
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	RAT|RGD=3250|UniProtKB=P35465	Serine/threonine-protein kinase PAK 1	ISS	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	CHICK|Ensembl=ENSGALG00000007509|UniProtKB=F1NM72	Uncharacterized protein	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00012	Cadherin signaling pathway	P00471	Cadherin	ORNAN|Ensembl=ENSOANG00000002498|UniProtKB=F6VFP8	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF106	CADHERIN-18
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008422|UniProtKB=F6VUT7	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04393	Ras Pathway	P04561	SRF	MOUSE|MGI=MGI=106658|UniProtKB=Q9JM73	Serum response factor	IDA	8660892	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DANRE|ZFIN=ZDB-GENE-040625-35|UniProtKB=Q6IQL9	Novel actin protein	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00030	Hypoxia response via HIF activation	P00824	PTEN	DROME|FlyBase=FBgn0026379|UniProtKB=Q7KMQ6	IP16020p	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000008186|UniProtKB=H2QB90	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF273	CADHERIN-8
P00018	EGF receptor signaling pathway	P00562	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01443	Phospholipase C	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01323	I kappa B	RAT|RGD=3171|UniProtKB=Q63746	NF-kappa-B inhibitor alpha	ISS	12637573	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	8687404	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P02751	Lysine biosynthesis	P03012	N-succinyl-diaminopimelate desuccinylase	METJA|EnsemblGenome=MJ_0457|UniProtKB=Q57899	Uncharacterized metallohydrolase MJ0457	ISS			PTHR43808:SF3	ACETYLORNITHINE DEACETYLASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BOVIN|Ensembl=ENSBTAG00000005714|UniProtKB=Q3ZC07	Actin, alpha cardiac muscle 1	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00981	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00006	Apoptosis signaling pathway	P00317	Fos	RAT|RGD=2626|UniProtKB=P12841	Proto-oncogene c-Fos	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000002658|UniProtKB=F7CB14	Uncharacterized protein	ISS	2039532	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P05918	p38 MAPK pathway	P06015	p38gamma	DANRE|ZFIN=ZDB-GENE-990415-257|UniProtKB=O42376	Mitogen-activated protein kinase 12	ISS	11274345	PubMed	PTHR24055:SF339	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IGI	98189216	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	MOUSE|MGI=MGI=1351339|UniProtKB=Q14BI2	Metabotropic glutamate receptor 2	ISS	12351712	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P02738	De novo purine biosynthesis	P02901	Adenosuccinate lyase	AQUAE|EnsemblGenome=aq_597|UniProtKB=O66856	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	TAS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	SULSO|EnsemblGenome=SSO0382|UniProtKB=Q980D3	Glutamine-fructose-6-phosphate transaminase (Isomerizing) (GlmS-1)	ISS			PTHR10937:SF0	GH12731P-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00023	General transcription regulation	P00668	TFIIB	CAEEL|WormBase=WBGene00006648|UniProtKB=O16991	Transcription initiation factor IIB	ISS	180660	OMIM	PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	RAT|RGD=1311791|UniProtKB=Q4KLF8	Actin-related protein 2/3 complex subunit 5	ISS	9230079	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00057	Wnt signaling pathway	P01451	Galpha	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	PYRAE|EnsemblGenome=PAE1964|UniProtKB=Q8ZW57	Aspartate aminotransferase (AspC), conjectural	ISS			PTHR43488:SF2	GLUTAMATE-PYRUVATE AMINOTRANSFERASE ALAA
P00060	Ubiquitin proteasome pathway	P01491	E2	MACMU|Ensembl=ENSMMUG00000030126|UniProtKB=F7HH32	Uncharacterized protein	ISS			PTHR43902:SF2	UBIQUITIN-CONJUGATING ENZYME E2 N
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	RAT|RGD=1309725|UniProtKB=D3ZB71	Protein Dvl2	ISS	10409711	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P00009	Axon guidance mediated by netrin	P00356	UNC-5	CHICK|Gene=UNC5C|UniProtKB=Q7T2Z5	Netrin receptor UNC5C	ISS			PTHR12582:SF7	NETRIN RECEPTOR UNC5C
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000001067|UniProtKB=E1BAB4	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	IGI	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00018	EGF receptor signaling pathway	P00559	MEK1-2	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IGI	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00019	Endothelin signaling pathway	P00584	Gs	DROME|FlyBase=FBgn0001123|UniProtKB=P20354	G protein alpha s subunit	ISS	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00020	FAS signaling pathway	P00615	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ORNAN|Ensembl=ENSOANG00000007716|UniProtKB=F6UDX9	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00053	T cell activation	P01312	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_116948|UniProtKB=C3YKS6	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF359	SUBFAMILY NOT NAMED
P00046	Oxidative stress response	P01131	MKP5	MACMU|Ensembl=ENSMMUG00000011570|UniProtKB=F7BLG8	Uncharacterized protein	ISS			PTHR10159:SF385	SERINE/THREONINE/TYROSINE-INTERACTING PROTEIN
P00019	Endothelin signaling pathway	P00590	IP3 R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	IC	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000010521|UniProtKB=F7DQK7	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00059	p53 pathway	P04633	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DICPU|Gene=DICPUDRAFT_48914|UniProtKB=F0ZK40	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF154	ACTIN-17-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CHICK|Ensembl=ENSGALG00000027629|UniProtKB=Q5ZJ03	Guanine nucleotide-binding protein subunit gamma	IDA	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00964	p90RSK	CHICK|Ensembl=ENSGALG00000000366|UniProtKB=P18652	Ribosomal protein S6 kinase 2 alpha	ISS	2779569	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00036	Interleukin signaling pathway	P00965	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02757	O-antigen biosynthesis	P03046	dTDP-glucose pyrophosphorylase	ECOLI|EcoGene=EG11454|UniProtKB=P61887	Glucose-1-phosphate thymidylyltransferase 2	ISS			PTHR43532:SF3	GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE 2
P00024	Glycolysis	P00679	Aldolase	MOUSE|MGI=MGI=87994|UniProtKB=P05064	Fructose-bisphosphate aldolase A	ISS	4812352	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00018	EGF receptor signaling pathway	P00549	EGF	PANTR|Ensembl=ENSPTRG00000012031|UniProtKB=H2QI26	Uncharacterized protein	ISS	4507461	gi	PTHR10740:SF1	PROTRANSFORMING GROWTH FACTOR ALPHA
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	XENTR|Xenbase=XB-GENE-484003|UniProtKB=Q6P365	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00944	Actin	MOUSE|MGI=MGI=2444552|UniProtKB=Q8BFZ3	Beta-actin-like protein 2	ISS	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P04393	Ras Pathway	P04557	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	IDA	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	DANRE|ZFIN=ZDB-GENE-000330-9|UniProtKB=Q90ZE4	Presenilin-2	IDA	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CANLF|Ensembl=ENSCAFG00000023094|UniProtKB=Q076A8	Developmental myosin heavy chain embryonic	ISS	89264452	PubMed	PTHR13140:SF427	MYOSIN-3
P05916	Opioid prodynorphin pathway	P06002	G-protein	DROME|FlyBase=FBgn0001105|UniProtKB=P26308	Guanine nucleotide-binding protein subunit beta-1	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	IC	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	IDA	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00029	Huntington disease	P00790	beta-Tubulin	BATDJ|Gene=BATDEDRAFT_37213|UniProtKB=F4P7H8	Alpha-Beta tubulin	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00049	Parkinson disease	P01231	gamma-Synuclein	RAT|RGD=70996|UniProtKB=Q63544	Gamma-synuclein	ISS			PTHR13820:SF10	GAMMA-SYNUCLEIN
P00057	Wnt signaling pathway	P01443	Phospholipase C	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04393	Ras Pathway	P04578	Rho	CHICK|Ensembl=ENSGALG00000001569|UniProtKB=Q9PSX7	Rho-related GTP-binding protein RhoC	ISS	14871999	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P02754	Methylcitrate cycle	P03028	Aconitase	BACSU|EnsemblGenome=BSU18000|UniProtKB=P09339	Aconitate hydratase A	ISS			PTHR11670:SF1	ACONITATE HYDRATASE
P00018	EGF receptor signaling pathway	P00562	p38	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00021	FGF signaling pathway	P00644	p38	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00047	PDGF signaling pathway	P01173	STAT	HUMAN|HGNC=11362|UniProtKB=P42224	Signal transducer and activator of transcription 1-alpha/beta	ISS	14755057	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Ensembl=ENSCAFG00000006805|UniProtKB=F1Q1Q4	Uncharacterized protein	ISS	11781138	PubMed	PTHR24248:SF26	ALPHA-2B ADRENERGIC RECEPTOR
P00018	EGF receptor signaling pathway	P00542	EGFR	MACMU|Ensembl=ENSMMUG00000020758|UniProtKB=F7HEH3	Uncharacterized protein	ISS	20477399	gi	PTHR24416:SF88	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	176910	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00054	Toll receptor signaling pathway	P01355	AP1	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00057	Wnt signaling pathway	P01458	Protein Kinase C	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04393	Ras Pathway	P04541	p90RSK	RAT|RGD=620676|UniProtKB=F1M7N7	Ribosomal protein S6 kinase	ISS	15526037	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00018	EGF receptor signaling pathway	P00564	Rac	DICDI|dictyBase=DDB_G0269176|UniProtKB=O96390	Rho-related protein racF1	ISS			PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P02781	Threonine biosynthesis	P03189	Aspartate kinase	THEMA|EnsemblGenome=TM_0547|UniProtKB=Q9WZ17	Aspartokinase II	ISS			PTHR21499:SF3	ASPARTOKINASE
P00005	Angiogenesis	P00206	Wnt	PANTR|Ensembl=ENSPTRG00000012931|UniProtKB=H2QJF8	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00752	cGMP-gated ion channel	RAT|RGD=621809|UniProtKB=F1LQB8	Protein Cngb1	IDA	12432397	PubMed	PTHR10217:SF386	CYCLIC NUCLEOTIDE-GATED CATION CHANNEL BETA-1
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	NAS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00587	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	DROME|FlyBase=FBgn0263111|UniProtKB=P91645	Voltage-dependent calcium channel type A subunit alpha-1	ISS	14624853	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P00060	Ubiquitin proteasome pathway	P01492	E1	HUMAN|HGNC=16935|UniProtKB=O95352	Ubiquitin-like modifier-activating enzyme ATG7	ISS			PTHR10953:SF3	UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Ensembl=ENSBTAG00000006582|UniProtKB=E1BFV6	Uncharacterized protein	ISS	12441358	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P04397	p53 pathway by glucose deprivation	P04641	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	HUMAN|HGNC=4588|UniProtKB=O15399	Glutamate receptor ionotropic, NMDA 2D	ISS	11319238	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	IDA	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00006	Apoptosis signaling pathway	P00317	Fos	RAT|RGD=2626|UniProtKB=P12841	Proto-oncogene c-Fos	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04395	Vasopressin synthesis	P04596	Endo Peptidase	MYCTU|EnsemblGenome=LH57_04235|UniProtKB=P71835	Peptidase	ISS			PTHR11757:SF3	PROTEASE 2
P05731	GABA-B receptor II signaling	P05754	Ggamma	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_56687|UniProtKB=C3YC50	Putative uncharacterized protein	IC	3487386	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	RCA	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00054	Toll receptor signaling pathway	P01368	MKK2	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000013693|UniProtKB=H2QKP9	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF81	CADHERIN-4
P00025	Hedgehog signaling pathway	P00691	CBP	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00011	Blood coagulation	P00406	Fibrinogen	HUMAN|HGNC=3662|UniProtKB=P02675	Fibrinogen beta chain	ISS	223002	gi	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00036	Interleukin signaling pathway	P00983	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00053	T cell activation	P01312	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8440264	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00020	FAS signaling pathway	P00615	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00029	Huntington disease	P00778	NMDA receptor	MACMU|Ensembl=ENSMMUG00000001661|UniProtKB=F7GR69	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00009	Axon guidance mediated by netrin	P00357	Netrin	BOVIN|Ensembl=ENSBTAG00000012137|UniProtKB=F1N0C7	Uncharacterized protein	ISS	11356879	PubMed	PTHR10574:SF365	NETRIN-1
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	IXOSC|EnsemblGenome=ISCW014549|UniProtKB=B7QGY5	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	PHYPA|Gene=PHYPADRAFT_226658|UniProtKB=A9TYG3	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00018	EGF receptor signaling pathway	P00539	14-3-3	MONDO|Ensembl=ENSMODG00000006158|UniProtKB=F7BS95	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00018	EGF receptor signaling pathway	P00555	MKK4,7	CANLF|Ensembl=ENSCAFG00000017851|UniProtKB=F1PBB6	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00049	Parkinson disease	P01242	Casein kinase I	MACMU|Ensembl=ENSMMUG00000010122|UniProtKB=F7HF84	Casein kinase I isoform epsilon	ISS	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00057	Wnt signaling pathway	P01444	Wnt	BOVIN|Ensembl=ENSBTAG00000016012|UniProtKB=F1N5R1	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P00021	FGF signaling pathway	P00628	JNK1-3	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS			PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	RCA			PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00012	Cadherin signaling pathway	P00475	Frizzled	MOUSE|MGI=MGI=108520|UniProtKB=Q61088	Frizzled-4	IDA	11212302	PubMed	PTHR11309:SF23	FRIZZLED-4
P02785	Valine biosynthesis	P03216	Acetolactate synthase	BACSU|EnsemblGenome=BSU36010|UniProtKB=Q04789	Acetolactate synthase	ISS			PTHR18968:SF129	SUBFAMILY NOT NAMED
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00951	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00539	14-3-3	CAEBR|Gene=CBG06174|UniProtKB=A8X0R4	Protein CBR-PAR-5	ISS	21643941	PubMed	PTHR18860:SF21	14-3-3-LIKE PROTEIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01443	Phospholipase C	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04393	Ras Pathway	P04557	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	RAT|RGD=1309329|UniProtKB=F1MAD0	Protein Lrp5	ISS	11907044	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00047	PDGF signaling pathway	P01167	Ets	HUMAN|HGNC=3444|UniProtKB=P50548	ETS domain-containing transcription factor ERF	ISS	15298723	PubMed	PTHR11849:SF31	ETS DOMAIN-CONTAINING TRANSCRIPTION FACTOR ERF
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00011	Blood coagulation	P00404	PAR-1	RAT|RGD=2586|UniProtKB=P26824	Proteinase-activated receptor 1	ISS	6978821	gi	PTHR24232:SF20	PROTEINASE-ACTIVATED RECEPTOR 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00005	Angiogenesis	P00213	FGF	BOVIN|Ensembl=ENSBTAG00000005198|UniProtKB=P03968	Fibroblast growth factor 1	ISS	87016918	PubMed	PTHR11486:SF86	FIBROBLAST GROWTH FACTOR 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	MONDO|Ensembl=ENSMODG00000017346|UniProtKB=F6WFF7	CTP synthase	ISS			PTHR11550:SF8	CTP SYNTHASE 1
P00047	PDGF signaling pathway	P01143	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	11204774	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00049	Parkinson disease	P01233	Elk-1	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	IDA	11050086	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00056	VEGF signaling pathway	P01407	Erk	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	MOUSE|MGI=MGI=88296|UniProtKB=O55017	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	11976940	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	ANOGA|EnsemblGenome=AGAP005731|UniProtKB=A7UTV1	AGAP005731-PA (Fragment)	ISS			PTHR15137:SF9	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	CANLF|Gene=HTR1D|UniProtKB=P11614	5-hydroxytryptamine receptor 1D	ISS	11701344	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P05913	Enkephalin release	P05974	G-Protein (i)	ANOGA|EnsemblGenome=AGAP005913|UniProtKB=Q7Q6D2	AGAP005913-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01444	Wnt	MONDO|Ensembl=ENSMODG00000010644|UniProtKB=F7D4J8	Protein Wnt (Fragment)	ISS	11266476	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00021	FGF signaling pathway	P00627	ERK1-2	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00549	EGF	MOUSE|MGI=MGI=1097165|UniProtKB=O35181	Pro-neuregulin-3, membrane-bound isoform	RCA			PTHR11100:SF18	PRO-NEUREGULIN-3, MEMBRANE-BOUND ISOFORM
P00021	FGF signaling pathway	P00629	PP2A	DAPPU|EnsemblGenome=DAPPUDRAFT_209708|UniProtKB=E9G8K4	Serine/threonine-protein phosphatase	ISS			PTHR11668:SF22	SERINE/THREONINE-PROTEIN PHOSPHATASE 4 CATALYTIC SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	HUMAN|HGNC=9508|UniProtKB=P49768	Presenilin-1	TAS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	DANRE|ZFIN=ZDB-GENE-000330-9|UniProtKB=Q90ZE4	Presenilin-2	TAS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00049	Parkinson disease	P01219	SAPK	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00005	Angiogenesis	P00187	beta catenin	MACMU|Ensembl=ENSMMUG00000014627|UniProtKB=F7GNE4	Catenin beta-1	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008422|UniProtKB=F6VUT7	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00012	Cadherin signaling pathway	P00463	betacatenin	TAKRU|Ensembl=ENSTRUG00000003520|UniProtKB=H2S791	Uncharacterized protein	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P06587	Nicotine pharmacodynamics pathway	P06612	CHRNB3	MOUSE|MGI=MGI=106212|UniProtKB=Q8BMN3	Neuronal acetylcholine receptor subunit beta-3	ISS	15155845	PubMed	PTHR18945:SF75	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-3
P00018	EGF receptor signaling pathway	P00547	PP2A	MOUSE|MGI=MGI=1321159|UniProtKB=P63330	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01298	NFkappaB	BOVIN|Ensembl=ENSBTAG00000006017|UniProtKB=F6Q9X9	Uncharacterized protein	ISS	12574369	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00047	PDGF signaling pathway	P01154	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00034	Integrin signalling pathway	P00928	alpha actinin	MONDO|Ensembl=ENSMODG00000013370|UniProtKB=F7DTH8	Uncharacterized protein	ISS	2116421	PubMed	PTHR43947:SF7	ALPHA-ACTININ-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000018059|UniProtKB=C7G3M9	Glutamate receptor, metabotropic 4	ISS	12351712	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	TAKRU|Ensembl=ENSTRUG00000010005|UniProtKB=H2TKG8	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00029	Huntington disease	G01533	Bax	XENTR|Xenbase=XB-GENE-486067|UniProtKB=Q6P4Y4	BCL2-associated X protein	ISS	14963330	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P00053	T cell activation	P01316	MHC-antigen	BOVIN|Ensembl=ENSBTAG00000010645|UniProtKB=Q30309	BoLA-DR-alpha	ISS	73139	PubMed	PTHR19944:SF63	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P05730	Endogenous cannabinoid signaling	P05746	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	9860142	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P02744	Fructose galactose metabolism	P02966	Hexokinase	MOUSE|MGI=MGI=96103|UniProtKB=P17710	Hexokinase-1	RCA			PTHR19443:SF10	HEXOKINASE-1
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	RAT|RGD=2871|UniProtKB=G3V824	Insulin-like growth factor 2 receptor, isoform CRA_b	ISS	13642251	gi	PTHR15071:SF17	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
P00036	Interleukin signaling pathway	P00965	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_114535|UniProtKB=C3ZHN2	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00020	FAS signaling pathway	P00610	MKK4	CANLF|Ensembl=ENSCAFG00000017851|UniProtKB=F1PBB6	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00059	p53 pathway	G04694	p110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00046	Oxidative stress response	P01134	cPLA2	BOVIN|Ensembl=ENSBTAG00000013298|UniProtKB=A4IFJ5	Cytosolic phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IGI	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00006	Apoptosis signaling pathway	P00269	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	ARATH|TAIR=AT3G05840|UniProtKB=P43289	Shaggy-related protein kinase gamma	TAS			PTHR24057:SF13	SHAGGY-RELATED PROTEIN KINASE ALPHA-RELATED
P00053	T cell activation	P01312	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	RAT|RGD=2735|UniProtKB=Q63273	Glutamate receptor ionotropic, kainate 5	ISS	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00029	Huntington disease	P00807	Actin	DROME|FlyBase=FBgn0000043|UniProtKB=P02572	Actin-42A	ISS	14684598	PubMed	PTHR11937:SF369	ACTIN-42A
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00011	Blood coagulation	P00446	FVIIIa	PANTR|Ensembl=ENSPTRG00000022455|UniProtKB=H2R1R6	Uncharacterized protein	ISS	4503647	gi	PTHR45309:SF1	COAGULATION FACTOR VIII
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8675|UniProtKB=Q9Y5H5	Protocadherin alpha-9	IDA	8120095	PubMed	PTHR24028:SF133	PROTOCADHERIN ALPHA-9
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	ORNAN|Ensembl=ENSOANG00000010302|UniProtKB=F6TDQ6	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	ISS	96149441	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P04398	p53 pathway feedback loops 2	G04714	PTEN	ARATH|TAIR=AT3G19420|UniProtKB=Q9LT75	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN2A	ISS			PTHR12305:SF32	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE TPTE2-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	RCA			PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	CANLF|Ensembl=ENSCAFG00000023338|UniProtKB=F1PKI6	Uncharacterized protein	ISS	10664585	PubMed	PTHR11462:SF7	TRANSCRIPTION FACTOR JUN-D
P00018	EGF receptor signaling pathway	P00564	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00057	Wnt signaling pathway	P01433	SIAH-1	MONDO|Ensembl=ENSMODG00000021275|UniProtKB=F7DVK7	E3 ubiquitin-protein ligase (Fragment)	ISS			PTHR10315:SF11	E3 UBIQUITIN-PROTEIN LIGASE SIAH2
P00021	FGF signaling pathway	P00626	Spry	CHICK|Gene=SPRY2|UniProtKB=Q9PTL2	Protein sprouty homolog 2	IGI	99429807	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=17175|UniProtKB=Q9P212	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	12860966	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00053	T cell activation	P01311	Raf	MOUSE|MGI=MGI=88190|UniProtKB=P28028	Serine/threonine-protein kinase B-raf	IDA	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00047	PDGF signaling pathway	P01142	p90RSK	MACMU|Ensembl=ENSMMUG00000002134|UniProtKB=F6UNV6	Ribosomal protein S6 kinase	ISS	10558991	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00034	Integrin signalling pathway	P00951	Jnk	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00019	Endothelin signaling pathway	P00590	IP3 R	ANOGA|EnsemblGenome=AGAP006475|UniProtKB=Q5TQX0	AGAP006475-PA	ISS	9065779	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00060	Ubiquitin proteasome pathway	P01491	E2	MONDO|Ensembl=ENSMODG00000010209|UniProtKB=F6SAT6	Uncharacterized protein	ISS			PTHR43898:SF4	UBIQUITIN-CONJUGATING ENZYME E2 A
P00052	TGF-beta signaling pathway	P01275	P38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	TAS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	TAKRU|Ensembl=ENSTRUG00000014376|UniProtKB=H2UII4	Uncharacterized protein	ISS			PTHR18945:SF60	ACETYLCHOLINE RECEPTOR SUBUNIT GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g234494|UniProtKB=A7RU31	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ARATH|TAIR=AT5G20000|UniProtKB=Q94BQ2	26S protease regulatory subunit 8 homolog B	ISS			PTHR23073:SF12	26S PROTEASE REGULATORY SUBUNIT 8
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00049	Parkinson disease	P01219	SAPK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	NAS	11007936	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00006	Apoptosis signaling pathway	P00303	c-Jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P02783	Tryptophan biosynthesis	P03211	Phosphribosyl anthranilate isomerase	METAC|EnsemblGenome=MA_2988|UniProtKB=Q8TLP6	N-(5'-phosphoribosyl)anthranilate isomerase	ISS			PTHR42894:SF1	N- 5'-PHOSPHORIBOSYL ANTHRANILATE ISOMERASE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02927	Dihydrooratate oxidase	CAEBR|Gene=CBG04047|UniProtKB=A8WW30	Protein CBR-DHOD-1	ISS			PTHR43517:SF1	DIHYDROOROTATE DEHYDROGENASE  QUINONE , MITOCHONDRIAL
P00053	T cell activation	P01300	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00398	IP3R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00199	JNKK1	CHICK|Ensembl=ENSGALG00000001001|UniProtKB=F1P3T1	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00006	Apoptosis signaling pathway	P00318	PKCs	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IDA	10395542	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00005	Angiogenesis	P00219	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MOUSE|MGI=MGI=95819|UniProtKB=P35438	Glutamate receptor ionotropic, NMDA 1	IC	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	RCA	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00047	PDGF signaling pathway	P01168	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00645	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CAEEL|WormBase=WBGene00000248|UniProtKB=Q18817	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF120	SUBFAMILY NOT NAMED
P00007	Axon guidance mediated by semaphorins	P00331	PAK	CHICK|Ensembl=ENSGALG00000000681|UniProtKB=E1C3P6	Uncharacterized protein	ISS	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	CANLF|Ensembl=ENSCAFG00000010107|UniProtKB=E2RA74	Serine/threonine-protein kinase receptor	ISS	9395284	PubMed	PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00010	B cell activation	P00373	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	12660731	PubMed	PTHR10048:SF14	PI-3 KINASE
P00059	p53 pathway	P04611	P300	MACMU|Ensembl=ENSMMUG00000000893|UniProtKB=F6T7D0	Histone acetyltransferase p300	ISS	8413673	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00047	PDGF signaling pathway	P01143	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00007	Axon guidance mediated by semaphorins	P00341	Rho	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04398	p53 pathway feedback loops 2	P04669	ATM	PANTR|Ensembl=ENSPTRG00000015483|UniProtKB=H2R801	Uncharacterized protein	ISS	10196661	PubMed	PTHR11139:SF69	SERINE/THREONINE-PROTEIN KINASE ATR
P00019	Endothelin signaling pathway	P00566	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	97449291	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	88241036	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00057	Wnt signaling pathway	P01463	Kremen	MACMU|Ensembl=ENSMMUG00000021370|UniProtKB=F7FIC8	Uncharacterized protein	ISS			PTHR24269:SF13	KREMEN PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	ANOGA|EnsemblGenome=AGAP005911|UniProtKB=Q7Q6D4	AGAP005911-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00053	T cell activation	P01320	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT3G59790|UniProtKB=Q9M1Z5	Mitogen-activated protein kinase 10	ISS	10514528	PubMed	PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P00049	Parkinson disease	P01238	14-3-3	MONDO|Ensembl=ENSMODG00000013658|UniProtKB=F6TY10	Uncharacterized protein	ISS	1317796	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02738	De novo purine biosynthesis	P02907	dADP kinase	ARATH|TAIR=AT4G23900|UniProtKB=Q8LAH8	Nucleoside diphosphate kinase IV, chloroplastic/mitochondrial	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P02765	Phenylalanine biosynthesis	P03099	Prephenate dehydratase	GLOVI|Gene=BAC88465|UniProtKB=Q7NN89	Prephenate dehydratase	ISS			PTHR21022:SF0	PREPHENATE DEHYDRATASE-RELATED
P00029	Huntington disease	P00807	Actin	TRIVA|Gene=TVAG_337240|UniProtKB=P90623	Actin	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	HUMAN|HGNC=4597|UniProtKB=P41594	Metabotropic glutamate receptor 5	ISS	14614461	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANAL|CGD=CAL0068551|UniProtKB=Q5AAR9	Phosphatidylinositol 3-kinase	ISS	10870104	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05913	Enkephalin release	P05978	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	ISS	8557110	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00057	Wnt signaling pathway	P01458	Protein Kinase C	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00057	Wnt signaling pathway	P01451	Galpha	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00010	B cell activation	P00373	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00872	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	RCA			PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANAL|CGD=CAL0003231|UniProtKB=Q5ANK2	Protein kinase C	ISS	96408767	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04393	Ras Pathway	P04566	Stat 1/3	MOUSE|MGI=MGI=103038|UniProtKB=P42227	Signal transducer and activator of transcription 3	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	MOUSE|MGI=MGI=1278315|UniProtKB=Q91VN0	Low-density lipoprotein receptor-related protein 5	ISS	11029006	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	BOVIN|Ensembl=ENSBTAG00000007172|UniProtKB=P12344	Aspartate aminotransferase, mitochondrial	ISS			PTHR11879:SF32	ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MOUSE|MGI=MGI=104798|UniProtKB=P06804	Tumor necrosis factor	ISS	11911478	PubMed	PTHR11471:SF23	TUMOR NECROSIS FACTOR
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	RAT|RGD=621705|UniProtKB=Q8VHN2	Glutamate receptor ionotropic, NMDA 3B	ISS	14698601	PubMed	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MACMU|Ensembl=ENSMMUG00000005819|UniProtKB=F6VKI4	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000009626|UniProtKB=F6ZYQ0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00036	Interleukin signaling pathway	P00983	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00186	FGFR-1	BOVIN|Ensembl=ENSBTAG00000015457|UniProtKB=A4IFL5	Fibroblast growth factor receptor	ISS	12799194	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P00005	Angiogenesis	P00219	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	PANTR|Ensembl=ENSPTRG00000007537|UniProtKB=H2R1H5	Uncharacterized protein	ISS	12356903	PubMed	PTHR10845:SF11	AXIN-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06768	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	RCA	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04547	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00513	Op18/stathmin	RAT|RGD=69349|UniProtKB=P63043	Stathmin-4	ISS			PTHR10104:SF6	STATHMIN-4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CAEEL|WormBase=WBGene00022500|UniProtKB=H2L0I2	Lin-5 (Five) Interacting protein	IC			PTHR23159:SF22	LIN-5  FIVE  INTERACTING PROTEIN
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05918	p38 MAPK pathway	P06029	p38beta	BOVIN|Ensembl=ENSBTAG00000030182|UniProtKB=G3X793	Mitogen-activated protein kinase	ISS	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CANLF|Ensembl=ENSCAFG00000012623|UniProtKB=F1PVP1	Uncharacterized protein	ISS	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00037	Ionotropic glutamate receptor pathway	P01026	KA	RAT|RGD=2735|UniProtKB=Q63273	Glutamate receptor ionotropic, kainate 5	ISS	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00030	Hypoxia response via HIF activation	P00824	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	CAEBR|Gene=CBG18174|UniProtKB=A8XT67	Protein CBR-ARX-3	ISS	12963527	gi	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MACMU|Ensembl=ENSMMUG00000016376|UniProtKB=F7G2W1	Uncharacterized protein	ISS	12697749	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00021	FGF signaling pathway	P00628	JNK1-3	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00029	Huntington disease	P00790	beta-Tubulin	CANLF|Ensembl=ENSCAFG00000019807|UniProtKB=F2Z4P1	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P05913	Enkephalin release	P05971	CREB	MACMU|Ensembl=ENSMMUG00000022601|UniProtKB=F6Z7G4	Cyclic AMP-responsive element-binding protein 1 isoform B	ISS	11752053	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00012	Cadherin signaling pathway	P00470	F-actin	ORNAN|Ensembl=ENSOANG00000000460|UniProtKB=F7F4W9	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00012	Cadherin signaling pathway	P00474	Wnt	BOVIN|Ensembl=ENSBTAG00000013990|UniProtKB=F1MN70	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=2136738|UniProtKB=Q91XZ6	Protein Pcdhb4	IDA	8120095	PubMed	PTHR24028:SF87	PROTEIN PCDHB4
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	LEPIN|EnsemblGenome=LA_0760|UniProtKB=Q9XD15	Adenylate kinase	ISS			PTHR23359:SF22	GTP:AMP PHOSPHOTRANSFERASE, MITOCHONDRIAL
P00019	Endothelin signaling pathway	P00575	furin	RAT|RGD=3274|UniProtKB=P23377	Furin	IGI	11861638	PubMed	PTHR42884:SF1	FURIN
P00047	PDGF signaling pathway	P01159	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	2837282	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	RAT|RGD=71014|UniProtKB=Q04400	Adenylate cyclase type 5	IC	2491850	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	PANTR|Ensembl=ENSPTRG00000000843|UniProtKB=H2QZN8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00019	Endothelin signaling pathway	P00589	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00545	JNK1-3	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	RAT|RGD=69079|UniProtKB=M0R9D3	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=16265|UniProtKB=Q9H1J7	Protein Wnt-5b	TAS	11266476	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00029	Huntington disease	P00790	beta-Tubulin	PRIPA|Gene=PPA21757|UniProtKB=H3FHL0	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	MOUSE|MGI=MGI=2444552|UniProtKB=Q8BFZ3	Beta-actin-like protein 2	IC	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00036	Interleukin signaling pathway	P00965	ERK	HUMAN|HGNC=6880|UniProtKB=Q13164	Mitogen-activated protein kinase 7	IC	15085193	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00648	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00005	Angiogenesis	P00182	p38MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00048	PI3 kinase pathway	P01199	Galpha	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	IC	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00005	Angiogenesis	P00186	FGFR-1	PANTR|Ensembl=ENSPTRG00000020176|UniProtKB=H2R210	Fibroblast growth factor receptor	ISS	9989949	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00235	c-Fos	RAT|RGD=2626|UniProtKB=P12841	Proto-oncogene c-Fos	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	94280860	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P02740	De novo pyrimidine ribonucleotides biosythesis	P02926	Aspartate carbamoyltransferase	THEMA|EnsemblGenome=TM_1642|UniProtKB=P96111	Protein PyrBI	ISS			PTHR11405:SF16	ASPARTATE CARBAMOYLTRANSFERASE, CHLOROPLASTIC
P05918	p38 MAPK pathway	P06034	MKK4	BOVIN|Ensembl=ENSBTAG00000012103|UniProtKB=A5PJP8	MAP2K4 protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00010	B cell activation	P00374	Lyn	HUMAN|HGNC=6735|UniProtKB=P07948	Tyrosine-protein kinase Lyn	IDA	1371009	PubMed	PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P00059	p53 pathway	P04623	CBP	ARATH|TAIR=AT1G55970|UniProtKB=Q9LG11	Histone acetyltransferase HAC4	IDA	10769018	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P05912	Dopamine receptor mediated signaling pathway	P05963	MAO	HUMAN|HGNC=6833|UniProtKB=P21397	Amine oxidase [flavin-containing] A	ISS	8602220	PubMed	PTHR43563:SF3	AMINE OXIDASE  FLAVIN-CONTAINING  A
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01219	SAPK	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00053	T cell activation	P01307	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000006495|UniProtKB=P11017	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00023	General transcription regulation	P00668	TFIIB	HALSA|EnsemblGenome=VNG_0869G|UniProtKB=Q9HR45	Transcription initiation factor IIB 4	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P00059	p53 pathway	P04616	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	15210700	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_79607|UniProtKB=C3ZHN4	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00011	Blood coagulation	P00440	ATIII	MACMU|Ensembl=ENSMMUG00000000629|UniProtKB=F6Y0N9	Uncharacterized protein	ISS	576554	gi	PTHR11461:SF53	ANTITHROMBIN-III
P00020	FAS signaling pathway	P00609	FAF1	MONDO|Ensembl=ENSMODG00000001243|UniProtKB=F7FWS4	Uncharacterized protein	ISS	8524870	PubMed	PTHR23322:SF52	FAS-ASSOCIATED FACTOR 1
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	MACMU|Ensembl=ENSMMUG00000010184|UniProtKB=F6SR09	Uncharacterized protein	ISS	8314195	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	MACMU|Ensembl=ENSMMUG00000014334|UniProtKB=F7CYY6	Uncharacterized protein	ISS	2039532	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8972|UniProtKB=O00750	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IDA	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00049	Parkinson disease	P01211	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00641	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IC	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	YEAST|SGD=S000000875|UniProtKB=P40047	Aldehyde dehydrogenase 5, mitochondrial	IC			PTHR11699:SF211	ALDEHYDE DEHYDROGENASE 5, MITOCHONDRIAL
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	IGI	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00056	VEGF signaling pathway	P01414	PLC-gamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00018	EGF receptor signaling pathway	P00560	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	MOUSE|MGI=MGI=97453|UniProtKB=P35454	Oxytocin-neurophysin 1	ISS	6717565	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P02755	Methylmalonyl pathway	P03034	Methylmalonyl-CoA mutase	BOVIN|Gene=MUT|UniProtKB=Q9GK13	Methylmalonyl-CoA mutase, mitochondrial	ISS			PTHR42710:SF1	METHYLMALONYL-COA MUTASE, MITOCHONDRIAL
P00053	T cell activation	P01332	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00024	Glycolysis	P00680	Phosphoglyceromutase	YEAST|SGD=S000001635|UniProtKB=P00950	Phosphoglycerate mutase 1	TAS	72161804	PubMed	PTHR11931:SF7	PHOSPHOGLYCERATE MUTASE 1
P00010	B cell activation	P00380	fos	PANTR|Ensembl=ENSPTRG00000006553|UniProtKB=A5A6H0	C-fos	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00047	PDGF signaling pathway	P01162	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MACMU|Ensembl=ENSMMUG00000006702|UniProtKB=F7HJS7	Serine/threonine-protein kinase receptor	ISS	9395284	PubMed	PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P00059	p53 pathway	G01579	PTEN	TAKRU|Ensembl=ENSTRUG00000009851|UniProtKB=H2TJ90	Uncharacterized protein	IGI	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00047	PDGF signaling pathway	P01161	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00010	B cell activation	P00383	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00223	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000019277|UniProtKB=H2QUQ1	Uncharacterized protein	ISS	1321498	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00010	B cell activation	P00402	Jnk	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00018	EGF receptor signaling pathway	P00563	Gab	BOVIN|Ensembl=ENSBTAG00000002813|UniProtKB=A6QLU3	GRB2-associated-binding protein 1	ISS	4503851	gi	PTHR12156:SF18	GRB2-ASSOCIATED-BINDING PROTEIN 1
P00005	Angiogenesis	P00235	c-Fos	RAT|RGD=2626|UniProtKB=P12841	Proto-oncogene c-Fos	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05925	beta-ARR1	HUMAN|HGNC=711|UniProtKB=P49407	Beta-arrestin-1	RCA	4757780	gi	PTHR11792:SF22	BETA-ARRESTIN-1
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00555	MKK4,7	PANTR|Ensembl=ENSPTRG00000008783|UniProtKB=H2QCA7	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00624	14-3-3	MONDO|Ensembl=ENSMODG00000015951|UniProtKB=F7FRT9	Uncharacterized protein	ISS	12861023	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00587	Raf-1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00956	SOCS	RAT|RGD=69261|UniProtKB=O70512	Cytokine-inducible SH2-containing protein (Fragment)	ISS	15032587	PubMed	PTHR44649:SF1	CYTOKINE-INDUCIBLE SH2-CONTAINING PROTEIN
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00054	Toll receptor signaling pathway	P01369	MKK1	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	ISS	22097630	PubMed	PTHR24070:SF189	GTPASE NRAS
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00045	Notch signaling pathway	P01113	Pen-2	XENTR|Xenbase=XB-GENE-854877|UniProtKB=F7C949	Presenilin	ISS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00048	PI3 kinase pathway	P01185	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05731	GABA-B receptor II signaling	P05760	AC	BOVIN|Ensembl=ENSBTAG00000005464|UniProtKB=E1B9K3	Uncharacterized protein	ISS	92357702	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04397	p53 pathway by glucose deprivation	P04641	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00047	PDGF signaling pathway	P01164	PDK1/2	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	ISS	9094314	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12805548	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	XENTR|Xenbase=XB-GENE-854877|UniProtKB=F7C949	Presenilin	ISS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05916	Opioid prodynorphin pathway	P06002	G-protein	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05730	Endogenous cannabinoid signaling	P05746	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00006	Apoptosis signaling pathway	P00318	PKCs	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00162	Pro-BACE-1	PANTR|Ensembl=ENSPTRG00000004324|UniProtKB=H2Q4U8	Beta-site APP-cleaving enzyme 1	ISS	10531052	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00029	Huntington disease	P00796	Kainate receptor	MOUSE|MGI=MGI=95816|UniProtKB=B1AS29	Glutamate receptor ionotropic, kainate 3	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00010	B cell activation	P00402	Jnk	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	XENTR|Xenbase=XB-GENE-1031985|UniProtKB=Q6GL68	Transcription factor 7-like 1	ISS	12356903	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04393	Ras Pathway	P04558	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02781	Threonine biosynthesis	P03190	Threonine synthase	METAC|EnsemblGenome=MA_1610|UniProtKB=Q8TQD4	Threonine synthase	ISS			PTHR10314:SF5	THREONINE SYNTHASE 1, CHLOROPLASTIC
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P06664	Gonadotropin-releasing hormone receptor pathway	P06841	gnaq/11	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	RCA	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04393	Ras Pathway	P04559	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12912997	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	PANTR|Ensembl=ENSPTRG00000018059|UniProtKB=C7G3M9	Glutamate receptor, metabotropic 4	ISS	11431030	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	12464394	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00020	FAS signaling pathway	P00615	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00013	Cell cycle	P00484	Cyclin D	MOUSE|MGI=MGI=88313|UniProtKB=P25322	G1/S-specific cyclin-D1	ISS	12356903	PubMed	PTHR10177:SF67	G1/S-SPECIFIC CYCLIN-D1
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	PANTR|Ensembl=ENSPTRG00000012128|UniProtKB=H2QI87	Uncharacterized protein	ISS	9118222	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P02775	Salvage pyrimidine ribonucleotides	P03152	Uridine phosphorylase	RAT|RGD=1308188|UniProtKB=D4A9N9	Uridine phosphorylase	ISS			PTHR43691:SF8	URIDINE PHOSPHORYLASE 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00190	RasGAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00020	FAS signaling pathway	P00610	MKK4	PANTR|Ensembl=ENSPTRG00000008783|UniProtKB=H2QCA7	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00048	PI3 kinase pathway	P01179	PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P06209	ALP23B signaling pathway	P06224	SMOX	DROME|FlyBase=FBgn0025800|UniProtKB=O96660	Mothers against decapentaplegic homolog	IEA	http://flybase.org/reports/FBrf0190369.html	Website	PTHR13703:SF25	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	IGI	94131269	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00029	Huntington disease	P00790	beta-Tubulin	PHYIT|EnsemblGenome=PITG_00156|UniProtKB=D0MT13	Beta-tubulin	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04395	Vasopressin synthesis	P04589	Signal Peptidase	XENTR|Xenbase=XB-GENE-950767|UniProtKB=F6WWE6	Uncharacterized protein	ISS	2092035	PubMed	PTHR12804:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 3
P06959	CCKR signaling map	G07002	VMAT2	HUMAN|HGNC=10935|UniProtKB=Q05940	Synaptic vesicular amine transporter	RCA	11459816	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000003399|UniProtKB=H2Q383	Phosphoinositide-3-kinase, class 2, alpha polypeptide	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00005	Angiogenesis	P00221	JNK1	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00053	T cell activation	P01311	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	G01579	PTEN	MOUSE|MGI=MGI=2446460|UniProtKB=G5E8H5	MCG118205, isoform CRA_c	IGI			PTHR12305:SF32	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE TPTE2-RELATED
P00053	T cell activation	P01332	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	RAT|RGD=1305848|UniProtKB=P85970	Actin-related protein 2/3 complex subunit 2	ISS	10940259	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00049	Parkinson disease	P01227	20S proteasome	CHICK|Ensembl=ENSGALG00000010060|UniProtKB=F1NEQ6	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF11	PROTEASOME SUBUNIT ALPHA TYPE-6
P00007	Axon guidance mediated by semaphorins	P00340	Rac	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00053	T cell activation	P01312	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00049	Parkinson disease	P01208	Hsp70	DANRE|ZFIN=ZDB-GENE-031001-11|UniProtKB=Q6P3L3	Heat shock protein 5	ISS	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00057	Wnt signaling pathway	P01451	Galpha	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00010	B cell activation	P00371	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05912	Dopamine receptor mediated signaling pathway	P05970	TH	TAKRU|Ensembl=ENSTRUG00000014467|UniProtKB=Q6IVY6	Tyrosine hydroxylase 2	ISS	12480184	PubMed	PTHR11473:SF35	SUBFAMILY NOT NAMED
P00025	Hedgehog signaling pathway	P00682	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00010	B cell activation	P00379	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00011	Blood coagulation	P00429	PN2	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	ISS	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P02788	Xanthine and guanine salvage pathway	P03250	Guanosine phosphorylase	CAEBR|Gene=CBG13501|UniProtKB=A8XI15	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00005	Angiogenesis	P00219	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1718748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	HUMAN|HGNC=5974|UniProtKB=P78552	Interleukin-13 receptor subunit alpha-1	TAS	8910586	PubMed	PTHR23036:SF89	INTERLEUKIN-13 RECEPTOR SUBUNIT ALPHA-1
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	HUMAN|HGNC=1389|UniProtKB=Q00975	Voltage-dependent N-type calcium channel subunit alpha-1B	TAS	14507926	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00024	Glycolysis	P00680	Phosphoglyceromutase	HUMAN|HGNC=1093|UniProtKB=P07738	Bisphosphoglycerate mutase	IDA	2542247	PubMed	PTHR11931:SF11	BISPHOSPHOGLYCERATE MUTASE
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MACMU|Ensembl=ENSMMUG00000007027|UniProtKB=F7F210	Alpha-cardiac actin	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P02744	Fructose galactose metabolism	P02966	Hexokinase	PANTR|Ensembl=ENSPTRG00000012104|UniProtKB=H2QI73	Hexokinase 2	RCA			PTHR19443:SF4	HEXOKINASE-2
P00048	PI3 kinase pathway	P01179	PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00021	FGF signaling pathway	P00642	MEK1-2	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	BOVIN|Ensembl=ENSBTAG00000014674|UniProtKB=P41985	Muscarinic acetylcholine receptor M2	ISS	12181435	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00019	Endothelin signaling pathway	P00586	Gq	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01154	Ras	CHICK|Ensembl=ENSGALG00000006885|UniProtKB=P08642	GTPase HRas	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00034	Integrin signalling pathway	P00941	Integrin alpha	RAT|RGD=2925|UniProtKB=A0A0G2K1E2	Integrin alpha 5 (Mapped)	ISS	3487386	PubMed	PTHR23220:SF3	INTEGRIN ALPHA-5
P06664	Gonadotropin-releasing hormone receptor pathway	P06780	ActRII/IIB	MOUSE|MGI=MGI=102806|UniProtKB=P27038	Activin receptor type-2A	RCA	9395284	PubMed	PTHR23255:SF64	ACTIVIN RECEPTOR TYPE-2A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	RCA			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	HUMAN|HGNC=4404|UniProtKB=P59768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IDA			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00056	VEGF signaling pathway	P01413	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	96009592	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00047	PDGF signaling pathway	P01162	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	PANTR|Ensembl=ENSPTRG00000013825|UniProtKB=H2RAK4	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	XENTR|Xenbase=XB-GENE-6067221|UniProtKB=F6Z0J4	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00887	IRS 1-4	PANTR|Ensembl=ENSPTRG00000012989|UniProtKB=H2QJJ4	Insulin receptor substrate 1	ISS	1311924	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00029	Huntington disease	P00774	Dynein complex	STRPU|EnsemblGenome=SPU_018567|UniProtKB=W4YRY2	Uncharacterized protein	ISS	9454836	PubMed	PTHR11886:SF52	DYNEIN LIGHT CHAIN 1, CYTOPLASMIC
P00034	Integrin signalling pathway	P00925	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IDA	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MONDO|Ensembl=ENSMODG00000000771|UniProtKB=F6SSS3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01452	NFAT	MOUSE|MGI=MGI=1920431|UniProtKB=Q8K120	Nuclear factor of activated T-cells, cytoplasmic 4	IDA	9133421	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00012	Cadherin signaling pathway	P00475	Frizzled	MOUSE|MGI=MGI=108460|UniProtKB=Q61091	Frizzled-8	IDA	8717036	PubMed	PTHR11309:SF90	FRIZZLED-8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00005	Angiogenesis	P00236	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P02738	De novo purine biosynthesis	P02894	IMP cyclohydrolase	CANLF|Ensembl=ENSCAFG00000014303|UniProtKB=F1P797	Uncharacterized protein	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	SCLS1|EnsemblGenome=SS1G_03482|UniProtKB=A7EDU2	Guanine nucleotide-binding protein beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_114976|UniProtKB=C3YP58	Putative uncharacterized protein	IDA	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	CHICK|Ensembl=ENSGALG00000007509|UniProtKB=F1NM72	Uncharacterized protein	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	PSEAE|EnsemblGenome=PA3807|UniProtKB=Q59636	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00036	Interleukin signaling pathway	P00986	eNOS	BOVIN|Gene=NOS3|UniProtKB=P29473	Nitric oxide synthase, endothelial	ISS	93055452	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	PANTR|Ensembl=ENSPTRG00000009200|UniProtKB=H2QD20	Signal transducer and activator of transcription	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	PYRAE|EnsemblGenome=PAE3518|UniProtKB=Q8ZSY7	CTP synthase	ISS			PTHR11550:SF0	CTP SYNTHASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	RCA	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00021	FGF signaling pathway	P00629	PP2A	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g195622|UniProtKB=A7T2Q5	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00385	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	IGI	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Gene=DRD2|UniProtKB=P20288	D(2) dopamine receptor	IDA	11861492	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	DEIRA|EnsemblGenome=DR_0789|UniProtKB=Q9RW80	Cysteine synthase	ISS			PTHR10314:SF159	CYSTEINE SYNTHASE A
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	RAT|RGD=71000|UniProtKB=Q9JLT0	Myosin-10	IC	89264452	PubMed	PTHR13140:SF328	MYOSIN-10
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	HUMAN|HGNC=1404|UniProtKB=O00305	Voltage-dependent L-type calcium channel subunit beta-4	IC			PTHR11824:SF7	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00870	IL2	MOUSE|MGI=MGI=96559|UniProtKB=P08505	Interleukin-6	IDA			PTHR45110:SF1	INTERLEUKIN-6
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04398	p53 pathway feedback loops 2	P04661	PI3K	XENTR|Xenbase=XB-GENE-6085226|UniProtKB=F6ZM84	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00021	FGF signaling pathway	P00629	PP2A	DICPU|Gene=DICPUDRAFT_47905|UniProtKB=F0ZLW0	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B	ISS			PTHR11871:SF0	PROTEIN PHOSPHATASE PP2A 55 KDA REGULATORY SUBUNIT
P00059	p53 pathway	G04702	p53	HUMAN|HGNC=11998|UniProtKB=P04637	Cellular tumor antigen p53	TAS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	MOUSE|MGI=MGI=99474|UniProtKB=Q91YI4	Beta-arrestin-2	IDA	4757780	gi	PTHR11792:SF20	BETA-ARRESTIN-2
P00048	PI3 kinase pathway	P01192	p110	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01211	ERK	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	IDA	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00005	Angiogenesis	P00238	Ras	BOVIN|Ensembl=ENSBTAG00000009778|UniProtKB=E1BMX0	Uncharacterized protein	ISS	99084794	PubMed	PTHR24070:SF186	GTPASE KRAS
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00057	Wnt signaling pathway	P01444	Wnt	RAT|RGD=628850|UniProtKB=B1WBR9	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00056	VEGF signaling pathway	P01407	Erk	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00053	T cell activation	P01325	LAT	RAT|RGD=620802|UniProtKB=O70601	Linker for activation of T-cells family member 1	ISS	9489702	PubMed	PTHR15586:SF0	LINKER FOR ACTIVATION OF T-CELLS FAMILY MEMBER 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	TAS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00034	Integrin signalling pathway	P00947	Laminin	MACMU|Ensembl=ENSMMUG00000000521|UniProtKB=F7A403	Netrin-4	ISS	2538453	PubMed	PTHR10574:SF282	NETRIN-4
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	TAKRU|Ensembl=ENSTRUG00000013411|UniProtKB=H2UB84	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DANRE|ZFIN=ZDB-GENE-000329-1|UniProtKB=Q7ZVI7	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	HUMAN|HGNC=1550|UniProtKB=P35520	Cystathionine beta-synthase	ISS			PTHR10314:SF8	CYSTATHIONINE BETA-SYNTHASE-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	HUMAN|HGNC=14088|UniProtKB=Q9UGC6	Regulator of G-protein signaling 17	IDA	8756726	PubMed	PTHR10845:SF196	REGULATOR OF G-PROTEIN SIGNALING 17
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CHICK|Ensembl=ENSGALG00000006638|UniProtKB=R4GGL9	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00011	Blood coagulation	P00431	tPA	HUMAN|HGNC=9051|UniProtKB=P00750	Tissue-type plasminogen activator	ISS	6572897	PubMed	PTHR44617:SF1	TISSUE-TYPE PLASMINOGEN ACTIVATOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IDA	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	MOUSE|MGI=MGI=1351338|UniProtKB=P97772	Metabotropic glutamate receptor 1	IC	7476890	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P04387	Histamine synthesis	P04493	Histidine decarboxylase	BOVIN|Ensembl=ENSBTAG00000009911|UniProtKB=Q5EA83	Histidine decarboxylase	ISS	1702422	PubMed	PTHR11999:SF68	HISTIDINE DECARBOXYLASE
P04393	Ras Pathway	P04564	MAPKAP	HUMAN|HGNC=6887|UniProtKB=P49137	MAP kinase-activated protein kinase 2	IDA	10779545	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	HUMAN|HGNC=18856|UniProtKB=Q96BA8	Cyclic AMP-responsive element-binding protein 3-like protein 1	RCA			PTHR22952:SF24	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00019	Endothelin signaling pathway	P00566	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	92020947	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00801	Fos protein	CANLF|Ensembl=ENSCAFG00000017040|UniProtKB=E2QYK5	Uncharacterized protein	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000011773|UniProtKB=F7HQF4	Uncharacterized protein	ISS			PTHR24247:SF31	5-HYDROXYTRYPTAMINE RECEPTOR 2B
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	TAS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	EMENI|EnsemblGenome=CADANIAG00006296|UniProtKB=Q5ASG1	Putative synaptobrevin homologue SNC1/2 (Eurofung)	ISS			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00052	TGF-beta signaling pathway	P01276	Co-Smads	PANTR|Ensembl=ENSPTRG00000010028|UniProtKB=H2QEJ6	Mothers against decapentaplegic homolog	ISS	10693808	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P00018	EGF receptor signaling pathway	P00552	Ras	XENTR|Xenbase=XB-GENE-494548|UniProtKB=F7EC26	Uncharacterized protein	ISS	20362513	PubMed	PTHR24070:SF186	GTPASE KRAS
P00021	FGF signaling pathway	P00629	PP2A	TRIAD|EnsemblGenome=TriadG63380|UniProtKB=B3S653	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04392	P53 pathway feedback loops 1	P04540	Cop-1	BOVIN|Ensembl=ENSBTAG00000031385|UniProtKB=F1MHX1	Uncharacterized protein	ISS	15103385	PubMed	PTHR44080:SF1	E3 UBIQUITIN-PROTEIN LIGASE RFWD2
P00048	PI3 kinase pathway	P01177	P110ACT	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	IC	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00586	Gq	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04397	p53 pathway by glucose deprivation	P04641	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00036	Interleukin signaling pathway	P00996	STAT	HUMAN|HGNC=11362|UniProtKB=P42224	Signal transducer and activator of transcription 1-alpha/beta	IC	14755057	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00048	PI3 kinase pathway	P01192	p110	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	ISS	12104050	PubMed	PTHR24070:SF189	GTPASE NRAS
P00054	Toll receptor signaling pathway	P01352	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00045	Notch signaling pathway	P01120	NIcs	RAT|RGD=3187|UniProtKB=Q07008	Neurogenic locus notch homolog protein 1	IEP	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00034	Integrin signalling pathway	P00907	ERK	PANTR|Ensembl=ENSPTRG00000020224|UniProtKB=H2Q9G3	Mitogen-activated protein kinase 6	ISS	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00848	Grb	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8316835	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00111	C99	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00018	EGF receptor signaling pathway	P00543	ERK1-2	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DROME|FlyBase=FBgn0010333|UniProtKB=P40792	Ras-related protein Rac1	ISS	8649368	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00005	Angiogenesis	P00221	JNK1	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MOUSE|MGI=MGI=108407|UniProtKB=P97428	Regulator of G-protein signaling 16	ISS	8756726	PubMed	PTHR10845:SF187	REGULATOR OF G-PROTEIN SIGNALING 16
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05923	beta-ARR2	MOUSE|MGI=MGI=99474|UniProtKB=Q91YI4	Beta-arrestin-2	RCA	12464600	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P04393	Ras Pathway	P04543	MEKK1/4	RAT|RGD=620966|UniProtKB=Q62925	Mitogen-activated protein kinase kinase kinase 1	IDA	12049732	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P02734	Chorismate biosynthesis	P02872	3-Dehydroquinate synthase	ECOLI|EcoGene=EG10074|UniProtKB=P07639	3-dehydroquinate synthase	ISS			PTHR43622:SF1	3-DEHYDROQUINATE SYNTHASE
P00017	DNA replication	P00530	Top	MOUSE|MGI=MGI=98788|UniProtKB=Q04750	DNA topoisomerase 1	RCA			PTHR10290:SF5	DNA TOPOISOMERASE 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02774	Salvage pyrimidine deoxyribonucleotides	P03147	Thymidine kinase	ECOLI|EcoGene=EG10994|UniProtKB=P23331	Thymidine kinase	ISS			PTHR11441:SF0	THYMIDINE KINASE, CYTOSOLIC
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05918	p38 MAPK pathway	P06015	p38gamma	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	8920915	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04393	Ras Pathway	P04558	p38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	DROME|FlyBase=FBgn0026379|UniProtKB=Q7KMQ6	IP16020p	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00022	General transcription by RNA polymerase I	P00657	TBP	ANOGA|EnsemblGenome=AGAP010958|UniProtKB=Q7PFI3	AGAP010958-PA	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00057	Wnt signaling pathway	P01444	Wnt	ORNAN|Gene=WNT2|UniProtKB=Q07DZ8	Protein Wnt-2	ISS	8717036	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00924	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	IGI	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	MOUSE|MGI=MGI=1926879|UniProtKB=Q9EQH4	Transcription initiation factor TFIID subunit 8	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	PANTR|Ensembl=ENSPTRG00000005197|UniProtKB=A5A6J7	Ras-related protein Rap-1b	ISS	10476970	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P06587	Nicotine pharmacodynamics pathway	P06598	EPB41L2	RAT|RGD=1563977|UniProtKB=D3ZM69	Protein Epb41l2	ISS	12181426	PubMed	PTHR23280:SF17	BAND 4.1-LIKE PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	XENTR|Xenbase=XB-GENE-493937|UniProtKB=Q5M8T9	Actin, alpha 2, smooth muscle, aorta	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00007	Axon guidance mediated by semaphorins	P00340	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	10891487	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00056	VEGF signaling pathway	P01423	p38MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	ARATH|TAIR=AT5G58700|UniProtKB=Q944C1	Phosphoinositide phospholipase C 4	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00018	EGF receptor signaling pathway	P00562	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00030	Hypoxia response via HIF activation	P00819	AKT	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00551	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01368	MKK2	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00057	Wnt signaling pathway	P01448	CBP	ARATH|TAIR=AT1G55970|UniProtKB=Q9LG11	Histone acetyltransferase HAC4	IDA	10769018	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00012	Cadherin signaling pathway	P00475	Frizzled	RAT|RGD=71012|UniProtKB=Q08464	Frizzled-2	IDA	8717036	PubMed	PTHR11309:SF34	FRIZZLED-2
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	NEUCR|EnsemblGenome=EFNCRG00000004595|UniProtKB=Q7RVB4	TATA-binding protein	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g169611|UniProtKB=A7SEB1	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	ARATH|TAIR=AT5G07880|UniProtKB=Q9SD96	SNAP25 homologous protein SNAP29	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00019	Endothelin signaling pathway	P00577	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	14526383	PubMed	PTHR10048:SF14	PI-3 KINASE
P00029	Huntington disease	P00790	beta-Tubulin	RAT|RGD=628595|UniProtKB=Q4QRB4	Tubulin beta-3 chain	TAS	12932731	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P05918	p38 MAPK pathway	P06021	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CAEBR|Gene=CBG12415|UniProtKB=A8XFD7	Protein CBR-SYX-7	ISS	14570579	PubMed	PTHR19957:SF209	LD23667P
P00047	PDGF signaling pathway	P01169	Vav	CHICK|Ensembl=ENSGALG00000001915|UniProtKB=R4GI39	Uncharacterized protein	ISS	14623913	PubMed	PTHR22826:SF97	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3
P00054	Toll receptor signaling pathway	P01338	IkappaB	RAT|RGD=3171|UniProtKB=Q63746	NF-kappa-B inhibitor alpha	ISS	10811867	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00054	Toll receptor signaling pathway	P01338	IkappaB	PANTR|Ensembl=ENSPTRG00000006265|UniProtKB=H2Q867	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	ISS	14665694	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	RCA	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00019	Endothelin signaling pathway	P00566	ERK	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	IGI	10851062	PubMed	PTHR24055:SF330	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00631	Grb2	MACMU|Ensembl=ENSMMUG00000005327|UniProtKB=F7GJG7	GRB2-related adapter protein	ISS	9741627	PubMed	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00047	PDGF signaling pathway	P01152	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P02755	Methylmalonyl pathway	P03033	Propionyl-CoA carboxylase	CAEEL|WormBase=WBGene00018701|UniProtKB=Q20676	Propionyl Coenzyme A Carboxylase Beta subunit	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00221	JNK1	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	ISS	97102675	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	RAT|RGD=3784|UniProtKB=P61265	Syntaxin-1B	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MACMU|Ensembl=ENSMMUG00000014807|UniProtKB=F6W548	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00053	T cell activation	P01300	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05734	Synaptic vesicle trafficking	P05779	Synaptobrevin	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IDA	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00047	PDGF signaling pathway	P01153	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00036	Interleukin signaling pathway	P00968	Ikk	HUMAN|HGNC=5960|UniProtKB=O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	IDA	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00053	T cell activation	P01312	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00036	Interleukin signaling pathway	P00990	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00762	HAP1	PANTR|Ensembl=ENSPTRG00000009177|UniProtKB=H2QD01	Uncharacterized protein	ISS	7477378	PubMed	PTHR15751:SF14	HUNTINGTIN-ASSOCIATED PROTEIN 1
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	PANTR|Ensembl=ENSPTRG00000006368|UniProtKB=H2Q8C3	Uncharacterized protein	ISS	10500304	PubMed	PTHR44282:SF2	SUPPRESSOR OF CYTOKINE SIGNALING 4
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	G01531	BDNF	DANRE|ZFIN=ZDB-GENE-000412-1|UniProtKB=Q6NZ01	Bdnf protein	IDA	12117585	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00019	Endothelin signaling pathway	P00572	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00057	Wnt signaling pathway	P01428	Frizzled	ORNAN|Ensembl=ENSOANG00000008874|UniProtKB=F7F2K2	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF23	FRIZZLED-4
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	BOVIN|Ensembl=ENSBTAG00000020590|UniProtKB=G3N2W8	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF34	FRIZZLED-2
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	MOUSE|MGI=MGI=1917497|UniProtKB=Q3TXS7	26S proteasome non-ATPase regulatory subunit 1	ISS			PTHR10943:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_127488|UniProtKB=C3XYC7	Putative uncharacterized protein	IDA	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00056	VEGF signaling pathway	P01425	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00056	VEGF signaling pathway	P01422	eNOS	MOUSE|MGI=MGI=97362|UniProtKB=P70313	Nitric oxide synthase, endothelial	ISS	10435050	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00729	Goalpha	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	IDA	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00010	B cell activation	P00384	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IDA	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	DROME|FlyBase=FBgn0012034|UniProtKB=Q9VP61	Acetyl-coenzyme A synthetase	ISS			PTHR24095:SF244	ACETYL-COENZYME A SYNTHETASE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00586	Gq	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	RAT|RGD=2740|UniProtKB=Q62645	Glutamate receptor ionotropic, NMDA 2D	IC	11319238	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00990	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CANAL|CGD=CAL0006348|UniProtKB=Q59Z23	Likely protein kinase	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	IC	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	8787761	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00204	PLD	BOVIN|Gene=PLD2|UniProtKB=Q0V8L6	Phospholipase D2	ISS	12615079	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	CAEEL|WormBase=WBGene00022455|UniProtKB=Q9N588	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00005	Angiogenesis	P00193	SOS-1	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00015	Circadian clock system	P00505	Cry	MACMU|Ensembl=ENSMMUG00000002453|UniProtKB=F7HH05	Cryptochrome-2	ISS	14507900	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00010	B cell activation	P00375	Calmodulin	RAT|RGD=2257|UniProtKB=P62161	Calmodulin	ISS	3885394	PubMed	PTHR23050:SF311	CALMODULIN
P00021	FGF signaling pathway	P00624	14-3-3	RAT|RGD=62000|UniProtKB=P62260	14-3-3 protein epsilon	ISS	98119747	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MOUSE|MGI=MGI=87909|UniProtKB=P62737	Actin, aortic smooth muscle	IC	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P06664	Gonadotropin-releasing hormone receptor pathway	P06847	JNK1/2	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	RCA	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	DANRE|ZFIN=ZDB-GENE-040116-1|UniProtKB=Q7ZUQ0	Actin related protein 2/3 complex, subunit 1A	ISS	12963527	gi	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	HUMAN|HGNC=7776|UniProtKB=Q13469	Nuclear factor of activated T-cells, cytoplasmic 2	ISS	12787506	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MOUSE|MGI=MGI=99673|UniProtKB=P84309	Adenylate cyclase type 5	ISS	94139935	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00021	FGF signaling pathway	P00624	14-3-3	MONDO|Ensembl=ENSMODG00000010174|UniProtKB=F6TA21	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	ARATH|TAIR=AT5G61210|UniProtKB=Q9S7P9	SNAP25 homologous protein SNAP33	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00019	Endothelin signaling pathway	P00590	IP3 R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00036	Interleukin signaling pathway	P00977	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01026	KA	CANLF|Ensembl=ENSCAFG00000003333|UniProtKB=F1PWT6	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=621505|UniProtKB=P0C865	Mitogen-activated protein kinase 7	ISS	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P04398	p53 pathway feedback loops 2	P04657	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00029	Huntington disease	P00788	Calpain	MOUSE|MGI=MGI=2181366|UniProtKB=Q91VA3	Calpain-8	IDA	11675509	PubMed	PTHR10183:SF374	CALPAIN-8
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT3G14720|UniProtKB=Q9LUC3	Mitogen-activated protein kinase 19	ISS	10851062	PubMed	PTHR24055:SF200	MITOGEN-ACTIVATED PROTEIN KINASE 18-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	HUMAN|HGNC=7579|UniProtKB=P35579	Myosin-9	ISS	89264452	PubMed	PTHR13140:SF317	MYOSIN-9
P04393	Ras Pathway	P04557	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Gene=PCDHB8|UniProtKB=Q5DRC6	Protocadherin beta-8	ISS	8120095	PubMed	PTHR24028:SF150	PROTOCADHERIN BETA-8
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	MOUSE|MGI=MGI=1351340|UniProtKB=Q9QYS2	Metabotropic glutamate receptor 3	ISS	9407094	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=621505|UniProtKB=P0C865	Mitogen-activated protein kinase 7	ISS	12912994	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P02736	Coenzyme A biosynthesis	P02885	Pantothenate kinase	BOVIN|Ensembl=ENSBTAG00000002479|UniProtKB=F1MLD0	Uncharacterized protein	ISS			PTHR12280:SF20	PANTOTHENATE KINASE 4
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00052	TGF-beta signaling pathway	P01284	JNK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00056	VEGF signaling pathway	P01407	Erk	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05913	Enkephalin release	P05974	G-Protein (i)	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	IC	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P02738	De novo purine biosynthesis	P02901	Adenosuccinate lyase	ARATH|TAIR=AT1G36280|UniProtKB=Q8GUN7	Adenylosuccinate lyase	ISS			PTHR43411:SF1	ADENYLOSUCCINATE LYASE
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05918	p38 MAPK pathway	P06043	ASK1	MACMU|Ensembl=ENSMMUG00000016376|UniProtKB=F7G2W1	Uncharacterized protein	ISS	8974401	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	RAT|RGD=2739|UniProtKB=Q00961	Glutamate receptor ionotropic, NMDA 2C	IC	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	PHYIT|EnsemblGenome=PITG_06514|UniProtKB=D0N511	Calmodulin	ISS	10487978	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00029	Huntington disease	P00786	ARF	CHICK|Ensembl=ENSGALG00000011651|UniProtKB=E1BVB0	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Gene=SSTR2|UniProtKB=P34993	Somatostatin receptor type 2	ISS	12181435	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P05916	Opioid prodynorphin pathway	P06002	G-protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	11535291	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P05731	GABA-B receptor II signaling	P05753	Ca channel	MOUSE|MGI=MGI=109482|UniProtKB=P97445	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	11976940	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00050	Plasminogen activating cascade	P01253	Fibrin	HUMAN|HGNC=3661|UniProtKB=P02671	Fibrinogen alpha chain	IDA	4503689	gi	PTHR19143:SF232	FIBRINOGEN ALPHA CHAIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	HUMAN|HGNC=236|UniProtKB=O95622	Adenylate cyclase type 5	IDA	2491850	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	IDA	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00034	Integrin signalling pathway	P00927	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00056	VEGF signaling pathway	P01407	Erk	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00036	Interleukin signaling pathway	P00983	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	TAS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04542	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05731	GABA-B receptor II signaling	P05754	Ggamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	RCA	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	1170702	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00462	Casein kinase II	BRAFL|Gene=BRAFLDRAFT_113587|UniProtKB=C3ZBE3	Putative uncharacterized protein	ISS	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00010	B cell activation	P00371	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=69426|UniProtKB=P34975	Kappa-type opioid receptor	IDA	11259487	PubMed	PTHR24229:SF1	KAPPA-TYPE OPIOID RECEPTOR
P02738	De novo purine biosynthesis	P02907	dADP kinase	ARATH|TAIR=AT4G11010|UniProtKB=O49203	Nucleoside diphosphate kinase III, chloroplastic/mitochondrial	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00030	Hypoxia response via HIF activation	P00817	TOR	MACMU|Ensembl=ENSMMUG00000019325|UniProtKB=F6RVV5	Uncharacterized protein	ISS	7518356	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00051	TCA cycle	P01266	Pyruvate Dehydrogenase	HUMAN|HGNC=8807|UniProtKB=P29803	Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial	RCA			PTHR11516:SF27	PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA, TESTIS-SPECIFIC FORM, MITOCHONDRIAL
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	RAT|RGD=2246|UniProtKB=Q07652	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	8386525	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P05915	Opioid proenkephalin pathway	P05985	Mu or Delta receptor	RAT|RGD=3234|UniProtKB=P33535	Mu-type opioid receptor	RCA	11259487	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00012	Cadherin signaling pathway	P00464	Fyn	PANTR|Ensembl=ENSPTRG00000018511|UniProtKB=H2QTK7	Tyrosine-protein kinase	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00034	Integrin signalling pathway	P00927	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00021	FGF signaling pathway	P00627	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	10875333	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	IC	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IGI	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04397	p53 pathway by glucose deprivation	G04706	TSC2	MOUSE|MGI=MGI=102548|UniProtKB=Q61037	Tuberin	IDA	12150915	PubMed	PTHR10063:SF0	TUBERIN
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00029	Huntington disease	P00807	Actin	PHYPA|Gene=PHYPADRAFT_109052|UniProtKB=A9TZ58	Actin 5	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04393	Ras Pathway	P04566	Stat 1/3	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00059	p53 pathway	P04609	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00591	PLCbeta	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	DROME|FlyBase=FBgn0010194|UniProtKB=P28466	Protein Wnt-5	TAS	11266476	PubMed	PTHR12027:SF77	PROTEIN WNT-5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00010	B cell activation	P00388	PLC gamma2	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	PANTR|Gene=CHRM5|UniProtKB=Q5IS53	Muscarinic acetylcholine receptor M5	ISS	10069496	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	SCHMA|EnsemblGenome=Smp_078040|UniProtKB=C4QIC0	Tubulin beta chain,putative	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	DROME|FlyBase=FBgn0031781|UniProtKB=Q9VMH2	Actin-related protein 2/3 complex subunit 4	ISS	5031595	gi	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00006	Apoptosis signaling pathway	P00277	Bi1	HUMAN|HGNC=11723|UniProtKB=P55061	Bax inhibitor 1	ISS			PTHR23291:SF34	BAX INHIBITOR 1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MOUSE|MGI=MGI=87905|UniProtKB=P68033	Actin, alpha cardiac muscle 1	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01447	Dishevelled	BOVIN|Ensembl=ENSBTAG00000019336|UniProtKB=F1MMW6	Uncharacterized protein	ISS	11212302	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P04395	Vasopressin synthesis	P04597	Signal Peptide	RAT|RGD=3238|UniProtKB=P01179	Oxytocin-neurophysin 1	ISS	1706187	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00010	B cell activation	P00386	Calcineurin	MONDO|Ensembl=ENSMODG00000020679|UniProtKB=F7DKU1	Serine/threonine-protein phosphatase	ISS	12091710	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000011757|UniProtKB=Q9XT97	Presenilin-1	IDA	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P02736	Coenzyme A biosynthesis	P02885	Pantothenate kinase	YEAST|SGD=S000002939|UniProtKB=Q04430	Pantothenate kinase CAB1	ISS			PTHR12280:SF20	PANTOTHENATE KINASE 4
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8700|UniProtKB=Q9Y5H1	Protocadherin gamma-A2	IDA	8120095	PubMed	PTHR24028:SF134	PROTOCADHERIN GAMMA-A2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DANRE|ZFIN=ZDB-GENE-050417-267|UniProtKB=F1QUN8	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF263	ACTIN
P00010	B cell activation	P00398	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04393	Ras Pathway	P04567	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00053	T cell activation	P01332	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IDA	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000010024|UniProtKB=H2QEJ2	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF25	MITOGEN-ACTIVATED PROTEIN KINASE 4
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00005	Angiogenesis	P00220	c-Jun	CHICK|Gene=JUN|UniProtKB=P18870	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00019	Endothelin signaling pathway	P00568	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	HUMAN|HGNC=10852|UniProtKB=P34897	Serine hydroxymethyltransferase, mitochondrial	ISS			PTHR11680:SF17	SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL
P00052	TGF-beta signaling pathway	P01275	P38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	CANLF|Ensembl=ENSCAFG00000004658|UniProtKB=Q8MJW8	C-C chemokine receptor type 4	ISS	12009564	PubMed	PTHR10489:SF608	C-C CHEMOKINE RECEPTOR TYPE 4
P00034	Integrin signalling pathway	P00937	Vinculin	MOUSE|MGI=MGI=98927|UniProtKB=Q64727	Vinculin	IPI	14702644	PubMed	PTHR18914:SF1	VINCULIN
P00018	EGF receptor signaling pathway	P00551	Akt	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	IGI	22084520	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04567	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05918	p38 MAPK pathway	P06021	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00052	TGF-beta signaling pathway	P01284	JNK	CAEEL|WormBase=WBGene00008200|UniProtKB=Q9U3L3	Uncharacterized protein	TAS			PTHR24055:SF253	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00589	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	HUMAN|HGNC=130|UniProtKB=P62736	Actin, aortic smooth muscle	IDA	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00012	Cadherin signaling pathway	P00470	F-actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g188243|UniProtKB=A7SCN8	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00021	FGF signaling pathway	P00624	14-3-3	ORYSJ|EnsemblGenome=OS11G0546900|UniProtKB=Q2R2W2	14-3-3-like protein GF14-D	ISS	10918058	PubMed	PTHR18860:SF34	SUBFAMILY NOT NAMED
P02741	Flavin biosynthesis	P02936	FAD synthetase	STRCO|Gene=CAB37472|UniProtKB=Q9Z530	Riboflavin biosynthesis protein	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	MOUSE|MGI=MGI=97453|UniProtKB=P35454	Oxytocin-neurophysin 1	ISS	9756087	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00005	Angiogenesis	P00204	PLD	RAT|RGD=3350|UniProtKB=P70498	Phospholipase D2	ISS	12615079	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00054	Toll receptor signaling pathway	P01355	AP1	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00018	EGF receptor signaling pathway	P00545	JNK1-3	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	HUMAN|HGNC=7567|UniProtKB=P12882	Myosin-1	ISS	89264452	PubMed	PTHR13140:SF484	MYOSIN-1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00021	FGF signaling pathway	P00634	MEKK1-5	MOUSE|MGI=MGI=1346873|UniProtKB=Q61083	Mitogen-activated protein kinase kinase kinase 2	ISS	21735556	gi	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	RCA			PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	TAKRU|Ensembl=ENSTRUG00000007912|UniProtKB=H2T4W3	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF83	PROTEIN WNT
P00053	T cell activation	P01324	rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	NAS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00047	PDGF signaling pathway	P01162	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01161	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01375	JNK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00004	Alzheimer disease-presenilin pathway	P00147	TACE	RAT|RGD=620404|UniProtKB=Q9Z1K9	Disintegrin and metalloproteinase domain-containing protein 17	TAS	12834808	PubMed	PTHR11905:SF171	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=12778|UniProtKB=O14904	Protein Wnt-9a	IDA	8717036	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00047	PDGF signaling pathway	P01143	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00048	PI3 kinase pathway	P01192	p110	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	BOVIN|Ensembl=ENSBTAG00000006159|UniProtKB=E1BNE9	G protein-activated inward rectifier potassium channel 1	ISS	2433589	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00059	p53 pathway	G04699	BAI-1	PANTR|Ensembl=ENSPTRG00000000465|UniProtKB=H2PYJ4	Uncharacterized protein	ISS			PTHR12011:SF41	ADHESION G PROTEIN-COUPLED RECEPTOR B2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=620023|UniProtKB=P10980	Muscarinic acetylcholine receptor M2	IDA	8100450	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00059	p53 pathway	P04609	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04564	MAPKAP	MOUSE|MGI=MGI=109298|UniProtKB=P49138	MAP kinase-activated protein kinase 2	IDA	9628873	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	DROME|FlyBase=FBgn0003719|UniProtKB=P25723	Dorsal-ventral patterning protein tolloid	TAS	12925593	PubMed	PTHR43978:SF2	DORSAL-VENTRAL PATTERNING PROTEIN TOLLOID-RELATED
P04393	Ras Pathway	P04546	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00017	DNA replication	P00533	Pol delta	SCHPO|PomBase=SPBC336.04|UniProtKB=P30316	DNA polymerase delta catalytic subunit	ISS	21848401	PubMed	PTHR10322:SF23	DNA POLYMERASE DELTA CATALYTIC SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00029	Huntington disease	P00780	Microtubule	MONDO|Ensembl=ENSMODG00000023805|UniProtKB=F7F082	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	ANOGA|EnsemblGenome=AGAP005911|UniProtKB=Q7Q6D4	AGAP005911-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04393	Ras Pathway	P04550	Ral	BOVIN|Ensembl=ENSBTAG00000006661|UniProtKB=Q3ZCK2	Uncharacterized protein	ISS	11025226	PubMed	PTHR24070:SF174	RAS-RELATED PROTEIN RAL-A
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00940	Src	MOUSE|MGI=MGI=98397|UniProtKB=P05480	Neuronal proto-oncogene tyrosine-protein kinase Src	ISS	11078745	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00034	Integrin signalling pathway	P00916	Ras	XENTR|Xenbase=XB-GENE-494548|UniProtKB=F7EC26	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	PANTR|Ensembl=ENSPTRG00000023608|UniProtKB=H2QZZ2	Uncharacterized protein	ISS	11554554	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CHICK|Ensembl=ENSGALG00000011086|UniProtKB=P68139	Actin, alpha skeletal muscle	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00054	Toll receptor signaling pathway	P01358	ERK1	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	DANRE|ZFIN=ZDB-GENE-051202-2|UniProtKB=Q6ZM67	Uncharacterized protein	ISS	11319238	PubMed	PTHR44391:SF3	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MOUSE|MGI=MGI=2429635|UniProtKB=Q91ZY2	Histamine H4 receptor	IDA			PTHR44152:SF1	HISTAMINE H4 RECEPTOR
P00048	PI3 kinase pathway	P01197	Caspase-9	HUMAN|HGNC=1511|UniProtKB=P55211	Caspase-9	ISS	9390557	PubMed	PTHR10454:SF157	CASPASE-9
P00056	VEGF signaling pathway	P01414	PLC-gamma	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00048	PI3 kinase pathway	P01176	JAK	RAT|RGD=2939|UniProtKB=Q62689	Tyrosine-protein kinase JAK2	ISS	12686512	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000008751|UniProtKB=H2QC89	Uncharacterized protein	ISS	129387	gi	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	IDA	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01286	TGFbeta	ANOGA|EnsemblGenome=AGAP011934|UniProtKB=Q7PZI7	AGAP011934-PA	TAS	9759503	PubMed	PTHR11848:SF54	PROTEIN 60A-RELATED
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00015	Circadian clock system	G01503	per	RAT|RGD=727863|UniProtKB=Q8CHI5	Period circadian protein homolog 1	ISS	20570170	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	11591316	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	RAT|RGD=2344|UniProtKB=P08485	Muscarinic acetylcholine receptor M4	ISS	11166329	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	PANTR|Ensembl=ENSPTRG00000028958|UniProtKB=P79240	C5a anaphylatoxin chemotactic receptor 1	ISS	6680818	gi	PTHR24225:SF29	C5A ANAPHYLATOXIN CHEMOTACTIC RECEPTOR 1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00049	Parkinson disease	P01211	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04397	p53 pathway by glucose deprivation	P04636	S6K	BOVIN|Gene=RPS6KB1|UniProtKB=Q6TJY3	Ribosomal protein S6 kinase beta-1	IDA	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	TAS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01457	GBeta	ANOGA|EnsemblGenome=AGAP001506|UniProtKB=Q7PXP3	AGAP001506-PA	ISS	9754712	PubMed	PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00057	Wnt signaling pathway	P01451	Galpha	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IDA	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00047	PDGF signaling pathway	P01142	p90RSK	BOVIN|Ensembl=ENSBTAG00000002015|UniProtKB=G5E5T2	Uncharacterized protein	ISS	6755374	gi	PTHR24351:SF98	RIBOSOMAL PROTEIN S6 KINASE ALPHA-6
P00016	Cytoskeletal regulation by Rho GTPase	P00507	Rho	ORNAN|Ensembl=ENSOANG00000008835|UniProtKB=F7FR08	Uncharacterized protein	ISS	13679859	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MACMU|Ensembl=ENSMMUG00000022347|UniProtKB=F6ZCH5	Uncharacterized protein	ISS	1648176	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	CANLF|Ensembl=ENSCAFG00000005526|UniProtKB=E2RKR0	Uncharacterized protein	ISS	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00052	TGF-beta signaling pathway	P01275	P38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00022	General transcription by RNA polymerase I	P00652	RNA Polymerase I  Complex	MACMU|Ensembl=ENSMMUG00000009468|UniProtKB=F7A8N8	DNA-directed RNA polymerase subunit beta	ISS	15691654	PubMed	PTHR20856:SF5	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA2
P00010	B cell activation	P00396	CD45	HUMAN|HGNC=9666|UniProtKB=P08575	Receptor-type tyrosine-protein phosphatase C	IGI	8940015	PubMed	PTHR19134:SF284	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C
P00049	Parkinson disease	P01238	14-3-3	CHLRE|EnsemblGenome=CHLREDRAFT_185967|UniProtKB=A8JGV6	14-3-3 protein	IDA	95359208	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	DANRE|ZFIN=ZDB-GENE-980526-40|UniProtKB=P31533	Homeobox protein engrailed-2b	IEP	12356903	PubMed	PTHR24341:SF5	HOMEOBOX PROTEIN ENGRAILED-2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04393	Ras Pathway	P04566	Stat 1/3	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	12191995	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P02723	Adenine and hypoxanthine salvage pathway	P02804	Hypoxanthine phosphoribosyl transferase	RAT|RGD=2826|UniProtKB=P27605	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF6	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MACMU|Ensembl=ENSMMUG00000017431|UniProtKB=F7HPP3	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	RAT|RGD=2869|UniProtKB=P24062	Insulin-like growth factor 1 receptor	ISS	2877871	PubMed	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00020	FAS signaling pathway	P00615	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	MOUSE|MGI=MGI=1353450|UniProtKB=P24549	Retinal dehydrogenase 1	IC			PTHR11699:SF140	RETINAL DEHYDROGENASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	BOVIN|Ensembl=ENSBTAG00000033153|UniProtKB=F1MG21	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT1G59580|UniProtKB=Q39022	Mitogen-activated protein kinase 2	ISS	9836510	gi	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00037	Ionotropic glutamate receptor pathway	P01001	KA4	RAT|RGD=2734|UniProtKB=Q01812	Glutamate receptor ionotropic, kainate 4	IC	11319238	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ORYSJ|EnsemblGenome=OS12G0163700|UniProtKB=Q0IPW3	Os12g0163700 protein	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04374	5HT2 type receptor mediated signaling pathway	P04413	K+ channel	BOVIN|Ensembl=ENSBTAG00000047488|UniProtKB=G3N1D1	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00021	FGF signaling pathway	P00629	PP2A	PANTR|Ensembl=ENSPTRG00000017377|UniProtKB=H2RCR7	Uncharacterized protein	ISS	9125135	PubMed	PTHR11871:SF1	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DANRE|ZFIN=ZDB-GENE-030131-7595|UniProtKB=Q6PBR4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00049	Parkinson disease	P01211	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00391	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00807	Actin	PANTR|Ensembl=ENSPTRG00000006890|UniProtKB=H2Q943	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00053	T cell activation	P01305	Calmodulin	MOUSE|MGI=MGI=103249|UniProtKB=P62204	Calmodulin	ISS	10487978	PubMed	PTHR23050:SF311	CALMODULIN
P00034	Integrin signalling pathway	P00951	Jnk	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02741	Flavin biosynthesis	P02934	Riboflavin kinase	BACTN|EnsemblGenome=BT_2543|UniProtKB=Q8A4Q4	Riboflavin biosynthesis protein	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	MACMU|Ensembl=ENSMMUG00000014817|UniProtKB=F6VXD8	Uncharacterized protein	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	RAT|RGD=69319|UniProtKB=P54313	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00025	Hedgehog signaling pathway	P00691	CBP	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	CANLF|Ensembl=ENSCAFG00000015081|UniProtKB=E2RMT4	Uncharacterized protein	ISS	12473693	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00010	B cell activation	P00373	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IGI	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00012	Cadherin signaling pathway	P00474	Wnt	CIOIN|Ensembl=ENSCING00000000407|UniProtKB=Q9U6V0	Protein Wnt	IDA	11266476	PubMed	PTHR12027:SF77	PROTEIN WNT-5
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000011838|UniProtKB=H2QHR7	Serine/threonine-protein kinase	ISS	12676944	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	MONDO|Ensembl=ENSMODG00000020977|UniProtKB=F6S5B1	Uncharacterized protein (Fragment)	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00029	Huntington disease	P00807	Actin	CAEBR|Gene=CBG02162|UniProtKB=A8WS33	Protein CBG02162	ISS	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00060	Ubiquitin proteasome pathway	P01490	E3	BOVIN|Ensembl=ENSBTAG00000020175|UniProtKB=P61085	Ubiquitin-conjugating enzyme E2 K	ISS			PTHR44020:SF2	UBIQUITIN-CONJUGATING ENZYME E2 K
P00025	Hedgehog signaling pathway	P00692	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00050	Plasminogen activating cascade	P01255	Plasminogen	MOUSE|MGI=MGI=97620|UniProtKB=P20918	Plasminogen	ISS	15928602	gi	PTHR24261:SF5	PLASMINOGEN
P00057	Wnt signaling pathway	P01444	Wnt	MACMU|Ensembl=ENSMMUG00000021725|UniProtKB=F7E738	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00624	14-3-3	CHICK|Gene_ORFName=RCJMB04_5e12|UniProtKB=Q5F3W6	14-3-3 protein gamma	ISS	22165492	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	XENTR|Xenbase=XB-GENE-491618|UniProtKB=Q6P378	Actin, cytoplasmic 2	ISS	11889139	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00054	Toll receptor signaling pathway	P01369	MKK1	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	HUMAN|HGNC=4404|UniProtKB=P59768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00776	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	12972619	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA			PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9836512	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CAEBR|Gene=CBG17587|UniProtKB=A8XRA5	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P05730	Endogenous cannabinoid signaling	P05746	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00059	p53 pathway	G01579	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	PANTR|Ensembl=ENSPTRG00000010386|UniProtKB=H2QF61	Tyrosine-protein kinase receptor	ISS	14500580	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	TAS	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00303	c-Jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00009	Axon guidance mediated by netrin	P00366	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12912997	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00036	Interleukin signaling pathway	P00972	MNK1/2	MOUSE|MGI=MGI=894316|UniProtKB=O08605	MAP kinase-interacting serine/threonine-protein kinase 1	IC	11575158	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00029	Huntington disease	P00796	Kainate receptor	ORNAN|Ensembl=ENSOANG00000002061|UniProtKB=F7ANC6	Uncharacterized protein	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00048	PI3 kinase pathway	G01545	scl-1	CAEEL|WormBase=WBGene00019179|UniProtKB=Q9N5N4	SCP-Like extracellular protein	ISS			PTHR10334:SF254	SCP-LIKE EXTRACELLULAR PROTEIN
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT1G53510|UniProtKB=Q9C5C0	Mitogen-activated protein kinase 18	ISS	10851062	PubMed	PTHR24055:SF200	MITOGEN-ACTIVATED PROTEIN KINASE 18-RELATED
P00005	Angiogenesis	P00242	TCF	MOUSE|MGI=MGI=1202879|UniProtKB=Q924A0	Transcription factor 7-like 2	ISS	11266476	PubMed	PTHR10373:SF32	TRANSCRIPTION FACTOR 7-LIKE 2
P00021	FGF signaling pathway	P00629	PP2A	PANTR|Ensembl=ENSPTRG00000017238|UniProtKB=H2QRH7	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	RCA	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00260	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00182	p38MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05918	p38 MAPK pathway	P06031	p38alpha	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00057	Wnt signaling pathway	P01447	Dishevelled	DROME|FlyBase=FBgn0000499|UniProtKB=P51140	Segment polarity protein dishevelled	ISS	7906389	PubMed	PTHR10878:SF25	SEGMENT POLARITY PROTEIN DISHEVELLED
P00010	B cell activation	P00385	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	XENTR|Xenbase=XB-GENE-487924|UniProtKB=F6WVD0	Casein kinase II subunit beta (Fragment)	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P06664	Gonadotropin-releasing hormone receptor pathway	G06690	CNP	MOUSE|MGI=MGI=97369|UniProtKB=Q61839	C-type natriuretic peptide	RCA			PTHR12167:SF2	C-TYPE NATRIURETIC PEPTIDE
P00006	Apoptosis signaling pathway	P00264	c-IAP1,2	MACMU|Ensembl=ENSMMUG00000003400|UniProtKB=F7FEH5	Baculoviral IAP repeat-containing protein 2	ISS			PTHR10044:SF79	BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	PANTR|Ensembl=ENSPTRG00000033819|UniProtKB=H2QV00	Actin related protein 2/3 complex, subunit 1A, 41kDa	ISS	12932731	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00048	PI3 kinase pathway	P01177	P110ACT	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00718	Phosphorylase a	MOUSE|MGI=MGI=97828|UniProtKB=Q8CI94	Glycogen phosphorylase, brain form	ISS	4318782	PubMed	PTHR11468:SF1	GLYCOGEN PHOSPHORYLASE, BRAIN FORM
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	HUMAN|HGNC=4584|UniProtKB=Q05586	Glutamate receptor ionotropic, NMDA 1	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00364	cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	EMENI|EnsemblGenome=CADANIAG00003444|UniProtKB=P16928	Acetyl-coenzyme A synthetase	ISS			PTHR24095:SF14	ACETYL-COENZYME A SYNTHETASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	RAT|RGD=3143|UniProtKB=Q9QYF3	Unconventional myosin-Va	IC			PTHR13140:SF273	UNCONVENTIONAL MYOSIN-VA
P02772	Pyruvate metabolism	P03140	Pyruvate Carboxylase	HUMAN|HGNC=8636|UniProtKB=P11498	Pyruvate carboxylase, mitochondrial	TAS	200246	gi	PTHR43778:SF2	PYRUVATE CARBOXYLASE, MITOCHONDRIAL
P02757	O-antigen biosynthesis	P03050	dTDP-4-dehydrorhamnose reductase	SULSO|EnsemblGenome=SSO0832|UniProtKB=Q7LXE6	dTDP-4-dehydrorhamnose reductase (RfbD-1)	ISS			PTHR43242:SF1	NAD P -BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN
P00048	PI3 kinase pathway	P01177	P110ACT	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00981	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DICPU|Gene=DICPUDRAFT_92985|UniProtKB=F1A084	Putative uncharacterized protein rac1A	ISS	4757952	gi	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00029	Huntington disease	P00807	Actin	DICDI|dictyBase=DDB_G0289811|UniProtKB=Q54GX7	Actin-10	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95817|UniProtKB=Q8BMF5	Glutamate receptor ionotropic, kainate 4	ISS	11319238	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01023	CaMKII	MOUSE|MGI=MGI=1341265|UniProtKB=Q6PHZ2	Calcium/calmodulin-dependent protein kinase type II subunit delta	ISS	12888804	PubMed	PTHR43940:SF4	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT DELTA
P00047	PDGF signaling pathway	P01168	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	10799299	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00047	PDGF signaling pathway	P01160	IP3 receptor	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12701063	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00015	Circadian clock system	G01501	cry	HUMAN|HGNC=2385|UniProtKB=Q49AN0	Cryptochrome-2	IDA	10428031	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	7492337	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000000914|UniProtKB=Q2KIP6	Kappa-type opioid receptor	ISS	11259498	PubMed	PTHR24229:SF1	KAPPA-TYPE OPIOID RECEPTOR
P00053	T cell activation	P01306	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P00053	T cell activation	P01332	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	TAS	14526383	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04393	Ras Pathway	P04570	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P06587	Nicotine pharmacodynamics pathway	P06597	CDK5	TAKRU|Ensembl=ENSTRUG00000004034|UniProtKB=H2SAY8	Uncharacterized protein	ISS	10604473	PubMed	PTHR24056:SF46	CYCLIN-DEPENDENT-LIKE KINASE 5
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00056	VEGF signaling pathway	P01414	PLC-gamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IGI	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00059	p53 pathway	G04694	p110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000026580|UniProtKB=F1MB93	Uncharacterized protein	ISS	11701344	PubMed	PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P00053	T cell activation	P01320	PLC-gamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BOVIN|Ensembl=ENSBTAG00000014614|UniProtKB=P62739	Actin, aortic smooth muscle	ISS	3487386	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00034	Integrin signalling pathway	P00925	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00021	FGF signaling pathway	P00647	SHP2	MONDO|Ensembl=ENSMODG00000003120|UniProtKB=F6WVD2	Tyrosine-protein phosphatase non-receptor type	ISS	14534538	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00629	PP2A	RAT|RGD=620919|UniProtKB=P36876	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform	IDA	12716901	PubMed	PTHR11871:SF2	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B ALPHA ISOFORM
P00046	Oxidative stress response	P01135	p38	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P06587	Nicotine pharmacodynamics pathway	P06605	KCNK3/9	RAT|RGD=61997|UniProtKB=O54912	Potassium channel subfamily K member 3	RCA	11875121	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P05731	GABA-B receptor II signaling	P05755	Gbeta	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00003	Alzheimer disease-amyloid secretase pathway	P00087	Fe65	CANLF|Ensembl=ENSCAFG00000006420|UniProtKB=E2QWV4	Uncharacterized protein	ISS	11441186	PubMed	PTHR14058:SF5	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1
P00059	p53 pathway	G01581	BAX	MOUSE|MGI=MGI=99702|UniProtKB=Q07813	Apoptosis regulator BAX	IGI	14963330	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	CANLF|Ensembl=ENSCAFG00000006607|UniProtKB=F1Q3Y2	Uncharacterized protein	ISS	3122041	gi	PTHR11647:SF57	DIHYDROPYRIMIDINASE-RELATED PROTEIN 3
P02747	Histidine biosynthesis	P02993	Phosphoribosylformimino-5-amino-1-phosphoribosyl-4 imadazol carboxamide isomerase	ARATH|TAIR=AT2G36230|UniProtKB=O82782	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic	ISS			PTHR43090:SF2	1- 5-PHOSPHORIBOSYL -5-  5-PHOSPHORIBOSYLAMINO METHYLIDENEAMINO  IMIDAZOLE-4-CARBOXAMIDE ISOMERASE
P00029	Huntington disease	P00807	Actin	TRIAD|EnsemblGenome=TriadG49626|UniProtKB=B3RKR4	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00797	p53	MOUSE|MGI=MGI=1924134|UniProtKB=Q5SQX6	Cytoplasmic FMR1-interacting protein 2	TAS			PTHR12195:SF1	CYTOPLASMIC FMR1-INTERACTING PROTEIN 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CHICK|Ensembl=ENSGALG00000026748|UniProtKB=F1P493	Uncharacterized protein	IC	10938134	PubMed	PTHR13140:SF728	MYOSIN HEAVY CHAIN, SKELETAL MUSCLE, ADULT
P00019	Endothelin signaling pathway	P00568	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IGI	3045562	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00024	Glycolysis	P00680	Phosphoglyceromutase	METAC|EnsemblGenome=MA_2400|UniProtKB=Q8TN93	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase	ISS	21929760	PubMed	PTHR11931:SF31	SUBFAMILY NOT NAMED
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	CANLF|Ensembl=ENSCAFG00000010617|UniProtKB=E2R543	Uncharacterized protein	ISS			PTHR11699:SF209	ALDEHYDE DEHYDROGENASE FAMILY 1 MEMBER A3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	DANRE|ZFIN=ZDB-GENE-021010-1|UniProtKB=Q90WY4	Alpha-2A adrenergic receptor	IDA	11781138	PubMed	PTHR24248:SF24	ALPHA-2A ADRENERGIC RECEPTOR
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	YEAST|SGD=S000003272|UniProtKB=P14681	Mitogen-activated protein kinase KSS1	ISS	6321477	gi	PTHR24055:SF338	MITOGEN-ACTIVATED PROTEIN KINASE KSS1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CHICK|Ensembl=ENSGALG00000028749|UniProtKB=Q5ZMQ2	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05731	GABA-B receptor II signaling	P05752	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	8838318	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00011	Blood coagulation	P00429	PN2	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	ISS	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05934	ELK1	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	RCA	3183861	gi	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00021	FGF signaling pathway	P00634	MEKK1-5	CANLF|Ensembl=ENSCAFG00000000760|UniProtKB=E2R9L4	Uncharacterized protein	ISS	12878610	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00049	Parkinson disease	P01238	14-3-3	RAT|RGD=3980|UniProtKB=P63102	14-3-3 protein zeta/delta	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00047	PDGF signaling pathway	P01142	p90RSK	MOUSE|MGI=MGI=1930076|UniProtKB=Q9Z2B9	Ribosomal protein S6 kinase alpha-4	ISS	6755374	gi	PTHR24351:SF41	RIBOSOMAL PROTEIN S6 KINASE ALPHA-4
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00023	General transcription regulation	P00669	TFIIEalpha	PANTR|Ensembl=ENSPTRG00000015273|UniProtKB=H2QN66	General transcription factor IIE, polypeptide 1, alpha 56kDa	ISS	189964	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	ORNAN|Ensembl=ENSOANG00000000943|UniProtKB=F6PJI8	Uncharacterized protein	ISS			PTHR13140:SF706	UNCONVENTIONAL MYOSIN-VI
P00057	Wnt signaling pathway	P01456	beta-arrestin	BOVIN|Ensembl=ENSBTAG00000020485|UniProtKB=P17870	Beta-arrestin-1	IDA	9388255	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P02748	Isoleucine biosynthesis	P02997	Acetolactate synthase	MYCTU|EnsemblGenome=Rv1820|UniProtKB=P9WG39	Acetolactate synthase large subunit IlvG	ISS			PTHR18968:SF156	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00046	Oxidative stress response	P01135	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05916	Opioid prodynorphin pathway	P06001	AC	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00006	Apoptosis signaling pathway	P00274	JNK	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	ISS	7600581	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01063	CAT	MACMU|Ensembl=ENSMMUG00000004692|UniProtKB=F6RM01	Uncharacterized protein	ISS	97225904	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01311	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000023525|UniProtKB=F7DX07	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF89	CADHERIN-5
P00021	FGF signaling pathway	P00641	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00057	Wnt signaling pathway	P01457	GBeta	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00049	Parkinson disease	P01238	14-3-3	PLAF7|EnsemblGenome=MAL8P1.69|UniProtKB=C0H4V6	14-3-3 protein	ISS	99404831	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	TAS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	DANRE|ZFIN=ZDB-GENE-020125-5|UniProtKB=A2CG69	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF356	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00916	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000000843|UniProtKB=H2QZN8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	RAT|RGD=619879|UniProtKB=G3V816	Nucleoside diphosphate kinase	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00048	PI3 kinase pathway	P01192	p110	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00020	FAS signaling pathway	P00614	ASK1	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS			PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00049	Parkinson disease	P01208	Hsp70	CAEBR|Gene=CBG08827|UniProtKB=A8X7H4	Protein CBR-HSP-6	ISS	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IGI	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00010	B cell activation	P00367	NFAT	HUMAN|HGNC=7778|UniProtKB=Q14934	Nuclear factor of activated T-cells, cytoplasmic 4	IDA	12787506	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00049	Parkinson disease	P01230	Src kinase	MACMU|Ensembl=ENSMMUG00000015267|UniProtKB=F7GRP2	Tyrosine-protein kinase	ISS	7687537	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00006	Apoptosis signaling pathway	P00269	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	BOVIN|Ensembl=ENSBTAG00000001067|UniProtKB=E1BAB4	Uncharacterized protein	ISS	20012997	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05916	Opioid prodynorphin pathway	P06002	G-protein	BRAFL|Gene=BRAFLDRAFT_220697|UniProtKB=C3ZSF0	Putative uncharacterized protein	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00053	T cell activation	P01331	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04393	Ras Pathway	P04546	GSK3	PANTR|Ensembl=ENSPTRG00000011049|UniProtKB=H2QGF9	Glycogen synthase kinase 3 alpha	ISS	21361340	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00057	Wnt signaling pathway	P01451	Galpha	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00976	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MOUSE|MGI=MGI=1933206|UniProtKB=A2AIR5	Protein Grin3a	ISS	11319238	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00056	VEGF signaling pathway	P01425	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01168	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00025	Hedgehog signaling pathway	P00689	Patched	DROME|FlyBase=FBgn0003892|UniProtKB=P18502	Protein patched	IDA	1653906	PubMed	PTHR10796:SF77	PROTEIN PATCHED
P00012	Cadherin signaling pathway	P00464	Fyn	TAKRU|Ensembl=ENSTRUG00000003538|UniProtKB=H2S7D1	Tyrosine-protein kinase	ISS	11162638	PubMed	PTHR24418:SF242	TYROSINE-PROTEIN KINASE FYNB
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	MOUSE|MGI=MGI=88397|UniProtKB=Q9ERZ4	Muscarinic acetylcholine receptor M2	ISS	12181435	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01444	Wnt	CANLF|Ensembl=ENSCAFG00000009672|UniProtKB=E2RDT2	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	BOVIN|Ensembl=ENSBTAG00000004279|UniProtKB=P61585	Transforming protein RhoA	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00018	EGF receptor signaling pathway	P00560	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MACMU|Ensembl=ENSMMUG00000022513|UniProtKB=F6YNZ0	Uncharacterized protein	ISS			PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P04398	p53 pathway feedback loops 2	P04665	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01437	TCF	MONDO|Ensembl=ENSMODG00000015573|UniProtKB=F7AIP6	Uncharacterized protein (Fragment)	ISS	9118222	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	G04715	CYCLIN G	MONDO|Ensembl=ENSMODG00000007651|UniProtKB=F7FZG0	Uncharacterized protein	ISS	7957050	PubMed	PTHR10177:SF59	CYCLIN-G1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DROME|FlyBase=FBgn0004623|UniProtKB=P29829	Guanine nucleotide-binding protein subunit beta-2	IC			PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P05915	Opioid proenkephalin pathway	P05994	G-protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01098	CHT1	DROME|FlyBase=FBgn0038641|UniProtKB=Q9VE46	High-affinity choline transporter 1	RCA			PTHR11819:SF12	HIGH-AFFINITY CHOLINE TRANSPORTER 1
P00047	PDGF signaling pathway	P01155	Jak	PANTR|Ensembl=ENSPTRG00000020744|UniProtKB=H2QWZ4	Tyrosine-protein kinase	ISS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00048	PI3 kinase pathway	P01192	p110	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04569	Cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00029	Huntington disease	P00774	Dynein complex	TAKRU|Ensembl=ENSTRUG00000003747|UniProtKB=H2S8S8	Uncharacterized protein	ISS	9454836	PubMed	PTHR11886:SF35	DYNEIN LIGHT CHAIN 2, CYTOPLASMIC
P00053	T cell activation	P01311	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IC	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00029	Huntington disease	P00790	beta-Tubulin	BRAFL|Gene=BRAFLDRAFT_120208|UniProtKB=C3YMF1	Putative uncharacterized protein	ISS			PTHR11588:SF89	TUBULIN BETA-4 CHAIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CANLF|Ensembl=ENSCAFG00000013148|UniProtKB=Q5R1P3	Glutamate receptor ionotropic, NMDA 2B	IC	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00049	Parkinson disease	P01211	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01230	Src kinase	MOUSE|MGI=MGI=103265|UniProtKB=Q922K9	Tyrosine-protein kinase FRK	IDA	9013950	PubMed	PTHR24418:SF296	TYROSINE-PROTEIN KINASE FRK
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	RCA	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IGI	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00021	FGF signaling pathway	P00647	SHP2	CHICK|Ensembl=ENSGALG00000004821|UniProtKB=Q90687	Tyrosine-protein phosphatase non-receptor type 11	ISS	7681589	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00019	Endothelin signaling pathway	P00590	IP3 R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	IGI	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	CAEBR|Gene=CBG17948|UniProtKB=A8XSM9	Actin-related protein 2/3 complex subunit 4	ISS	5031595	gi	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P06664	Gonadotropin-releasing hormone receptor pathway	P06742	NF-Y	MOUSE|MGI=MGI=107901|UniProtKB=P70353	Nuclear transcription factor Y subunit gamma	RCA			PTHR10252:SF8	NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA
P04395	Vasopressin synthesis	P04592	Exopeptidase	DANRE|ZFIN=ZDB-GENE-090313-68|UniProtKB=Q6NSM5	Uncharacterized protein	ISS	1778303	PubMed	PTHR11532:SF59	CARBOXYPEPTIDASE E
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00049	Parkinson disease	P01238	14-3-3	BOVIN|Ensembl=ENSBTAG00000005664|UniProtKB=P62261	14-3-3 protein epsilon	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P04398	p53 pathway feedback loops 2	P04668	p53	MOUSE|MGI=MGI=1336991|UniProtKB=Q9JJP2	Tumor protein p73	TAS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00036	Interleukin signaling pathway	P00990	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00011	Blood coagulation	P00429	PN2	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P02781	Threonine biosynthesis	P03190	Threonine synthase	STRCO|Gene=CAB93053|UniProtKB=Q9KXU8	Putative threonine synthase	ISS			PTHR10314:SF96	SUBFAMILY NOT NAMED
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00572	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00010	B cell activation	P00367	NFAT	PANTR|Ensembl=ENSPTRG00000013628|UniProtKB=H2R4F5	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00025	Hedgehog signaling pathway	P00682	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	9514948	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	RAT|RGD=71000|UniProtKB=Q9JLT0	Myosin-10	ISS	89264452	PubMed	PTHR13140:SF328	MYOSIN-10
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-961282|UniProtKB=Q6DF43	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05913	Enkephalin release	P05974	G-Protein (i)	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00036	Interleukin signaling pathway	P00983	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=621505|UniProtKB=P0C865	Mitogen-activated protein kinase 7	ISS	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00047	PDGF signaling pathway	P01148	Grb2	MOUSE|MGI=MGI=1333842|UniProtKB=O89100	GRB2-related adaptor protein 2	ISS	51702266	gi	PTHR24418:SF299	GRB2-RELATED ADAPTER PROTEIN 2
P05913	Enkephalin release	P05976	Enkephalin	XENTR|Xenbase=XB-GENE-942760|UniProtKB=F6Y5F6	Uncharacterized protein	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00057	Wnt signaling pathway	P01465	Ggamma	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	BOVIN|Ensembl=ENSBTAG00000000219|UniProtKB=F1MCL3	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	HUMAN|HGNC=17031|UniProtKB=Q8WTQ7	Rhodopsin kinase	IDA	8288567	PubMed	PTHR24355:SF12	RHODOPSIN KINASE
P00034	Integrin signalling pathway	P00941	Integrin alpha	RAT|RGD=71022|UniProtKB=Q63258	Integrin alpha-7	IPI	3487386	PubMed	PTHR23220:SF90	INTEGRIN ALPHA-7
P00021	FGF signaling pathway	P00642	MEK1-2	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02777	Succinate to proprionate conversion	P03161	Methylmalonyl-CoA mutase	SULSO|EnsemblGenome=SSO2266|UniProtKB=Q97WF7	Methylmalonyl-CoA mutase, alpha-subunit, chain B (McmA2)	ISS			PTHR23408:SF19	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	RAT|RGD=735207|UniProtKB=P80202	Activin receptor type-1B	TAS	9395284	PubMed	PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P00019	Endothelin signaling pathway	P00582	COX-2	DANRE|ZFIN=ZDB-GENE-020530-2|UniProtKB=Q6P4V3	Prostaglandin-endoperoxide synthase 2a	IGI	12011329	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P02751	Lysine biosynthesis	P03009	Aspartokinase	BACTN|EnsemblGenome=BT_1901|UniProtKB=Q8A6I3	Lysine-sensitive aspartokinase III	ISS			PTHR21499:SF38	ASPARTOKINASE 1, CHLOROPLASTIC
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=1306541|UniProtKB=D3ZVF3	Phosphoinositide-3-kinase, class 2, beta polypeptide (Predicted)	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9062|UniProtKB=Q9BRC7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	12860966	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00048	PI3 kinase pathway	P01190	PDK1 ACT	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	11256888	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05730	Endogenous cannabinoid signaling	P05751	Galpha	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00628	JNK1-3	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00023	General transcription regulation	P00660	RNA Polymerase II	TAKRU|Ensembl=ENSTRUG00000004676|UniProtKB=H2SFB7	Uncharacterized protein	ISS	2187864	PubMed	PTHR11800:SF2	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00034	Integrin signalling pathway	P00941	Integrin alpha	MOUSE|MGI=MGI=96606|UniProtKB=P24063	Integrin alpha-L	IPI	11457896	PubMed	PTHR23220:SF84	INTEGRIN ALPHA-L
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000018677|UniProtKB=H2QTV4	Syntaxin 11	ISS	11067767	PubMed	PTHR19957:SF30	SYNTAXIN-11
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MONDO|Ensembl=ENSMODG00000006241|UniProtKB=F7FRY0	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	SULSO|EnsemblGenome=SSO0530|UniProtKB=Q9UWT5	Serine hydroxymethyltransferase	ISS			PTHR11680:SF21	SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC
P00053	T cell activation	P01300	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	6264430	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00020	FAS signaling pathway	P00599	Caspase3	HUMAN|HGNC=1504|UniProtKB=P42574	Caspase-3	IGI	11675509	PubMed	PTHR10454:SF198	CASPASE-3
P00046	Oxidative stress response	P01131	MKP5	HUMAN|HGNC=18484|UniProtKB=Q8NEJ0	Dual specificity protein phosphatase 18	TAS			PTHR10159:SF313	DUAL SPECIFICITY PROTEIN PHOSPHATASE 18
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00782	alpha-Adaptin	PANTR|Ensembl=ENSPTRG00000003144|UniProtKB=H2Q2W5	Uncharacterized protein	ISS	11532990	PubMed	PTHR22780:SF4	AP-2 COMPLEX SUBUNIT ALPHA-2
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	DANRE|ZFIN=ZDB-GENE-990415-86|UniProtKB=O13166	Protein groucho-2	IDA	9783586	PubMed	PTHR10814:SF24	TRANSDUCIN-LIKE ENHANCER PROTEIN 3
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MACMU|Ensembl=ENSMMUG00000001304|UniProtKB=F7BNR8	Receptor protein serine/threonine kinase	ISS	10683140	PubMed	PTHR23255:SF61	TGF-BETA RECEPTOR TYPE-1
P04393	Ras Pathway	P04546	GSK3	CANLF|Ensembl=ENSCAFG00000004882|UniProtKB=F1PAE3	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01448	CBP	MOUSE|MGI=MGI=1276116|UniProtKB=B2RWS6	Histone acetyltransferase p300	ISS	10664585	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04393	Ras Pathway	P04543	MEKK1/4	MACMU|Ensembl=ENSMMUG00000012387|UniProtKB=F7EB20	Uncharacterized protein	ISS	8940199	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P02774	Salvage pyrimidine deoxyribonucleotides	P03147	Thymidine kinase	CAEBR|Gene=CBG04406|UniProtKB=A8WXG7	Thymidine kinase	ISS			PTHR11441:SF0	THYMIDINE KINASE, CYTOSOLIC
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04393	Ras Pathway	P04572	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	IDA	10851062	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00036	Interleukin signaling pathway	P00990	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02738	De novo purine biosynthesis	P02907	dADP kinase	SCHPO|PomBase=SPAC806.07|UniProtKB=P49740	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00019	Endothelin signaling pathway	P00577	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	BOVIN|Ensembl=ENSBTAG00000004242|UniProtKB=Q1JP79	Actin-related protein 2/3 complex subunit 1A	ISS	12932731	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00018	EGF receptor signaling pathway	P00561	STAT	DROME|FlyBase=FBgn0016917|UniProtKB=Q24151	Signal transducer and transcription activator	ISS			PTHR11801:SF43	SIGNAL TRANSDUCER AND TRANSCRIPTION ACTIVATOR
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	BOVIN|Ensembl=ENSBTAG00000010576|UniProtKB=A4IFH7	MAP2K3 protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00047	PDGF signaling pathway	P01171	PLCgamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00004	Alzheimer disease-presenilin pathway	P00111	C99	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00627	ERK1-2	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	NAS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00018	EGF receptor signaling pathway	P00562	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	CHICK|Ensembl=ENSGALG00000008339|UniProtKB=E1BQS9	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P06216	SCW signaling pathway	P06331	MAD	DROME|FlyBase=FBgn0011648|UniProtKB=P42003	Protein mothers against dpp	IGI	9395284	PubMed	PTHR13703:SF40	PROTEIN MOTHERS AGAINST DPP
P00053	T cell activation	P01319	PAK	MONDO|Ensembl=ENSMODG00000005255|UniProtKB=F7G800	Uncharacterized protein	ISS	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00046	Oxidative stress response	P01130	CHOP	MOUSE|MGI=MGI=109247|UniProtKB=P35639	DNA damage-inducible transcript 3 protein	TAS	10207617	PubMed	PTHR16833:SF0	DNA DAMAGE-INDUCIBLE TRANSCRIPT 3 PROTEIN
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02783	Tryptophan biosynthesis	P03211	Phosphribosyl anthranilate isomerase	LEPIN|EnsemblGenome=LA_2147|UniProtKB=Q8F495	N-(5'-phosphoribosyl)anthranilate isomerase	ISS			PTHR42894:SF1	N- 5'-PHOSPHORIBOSYL ANTHRANILATE ISOMERASE
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00029	Huntington disease	P00811	Arp2/3 complex	BOVIN|Ensembl=ENSBTAG00000046248|UniProtKB=Q58CQ2	Actin-related protein 2/3 complex subunit 1B	ISS	12473693	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MOUSE|MGI=MGI=1098271|UniProtKB=O08849	Regulator of G-protein signaling 2	ISS	8756726	PubMed	PTHR10845:SF43	REGULATOR OF G-PROTEIN SIGNALING 2
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P02723	Adenine and hypoxanthine salvage pathway	P02810	Adenine phosphoribosyl transferase	MOUSE|MGI=MGI=88061|UniProtKB=P08030	Adenine phosphoribosyltransferase	ISS			PTHR32315:SF3	ADENINE PHOSPHORIBOSYLTRANSFERASE
P00025	Hedgehog signaling pathway	P00683	Slimb	MACMU|Ensembl=ENSMMUG00000016008|UniProtKB=F7FVG8	Uncharacterized protein	ISS	12628165	PubMed	PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000018568|UniProtKB=F6YLW2	Uncharacterized protein	ISS			PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00059	p53 pathway	G04694	p110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	RAT|RGD=2845|UniProtKB=P19327	5-hydroxytryptamine receptor 1A	IEA	12181435	PubMed	PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00029	Huntington disease	P00805	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00541	Spry	PANTR|Ensembl=ENSPTRG00000017360|UniProtKB=H2QRP3	Uncharacterized protein	ISS	99264295	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P05913	Enkephalin release	P05974	G-Protein (i)	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00049	Parkinson disease	P01233	Elk-1	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	IDA	3183861	gi	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	DANRE|ZFIN=ZDB-GENE-991119-4|UniProtKB=Q9W6T7	Presenilin-1	TAS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00024	Glycolysis	P00671	Phosphoglycerate kinase	SULSO|EnsemblGenome=SSO0527|UniProtKB=P50317	Phosphoglycerate kinase	ISS	21332296	PubMed	PTHR11406:SF0	PHOSPHOGLYCERATE KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00566	ERK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	IGI	11707292	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00049	Parkinson disease	P01229	Pael-R	HUMAN|HGNC=4494|UniProtKB=O15354	Prosaposin receptor GPR37	IDA	12150907	PubMed	PTHR24243:SF32	PROSAPOSIN RECEPTOR GPR37
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	PANTR|Ensembl=ENSPTRG00000005635|UniProtKB=H2Q774	Syntaxin 2	ISS			PTHR19957:SF36	SYNTAXIN-2
P05917	Opioid proopiomelanocortin pathway	P06008	ACTH	PANTR|Ensembl=ENSPTRG00000011721|UniProtKB=H2R8Y3	Uncharacterized protein	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00049	Parkinson disease	P01236	Casein kinase II	MOUSE|MGI=MGI=88543|UniProtKB=Q60737	Casein kinase II subunit alpha	IDA	10806215	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00057	Wnt signaling pathway	P01457	GBeta	DROME|FlyBase=FBgn0004623|UniProtKB=P29829	Guanine nucleotide-binding protein subunit beta-2	ISS	9754712	PubMed	PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00057	Wnt signaling pathway	P01443	Phospholipase C	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00036	Interleukin signaling pathway	P00994	FKHRL1	HUMAN|HGNC=3821|UniProtKB=O43524	Forkhead box protein O3	IC	15031210	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00045	Notch signaling pathway	P01099	Notch	HUMAN|HGNC=7883|UniProtKB=Q9UM47	Neurogenic locus notch homolog protein 3	IC	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	TAKRU|Ensembl=ENSTRUG00000007253|UniProtKB=H2SZQ1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P06959	CCKR signaling map	P07151	p52 SHC1	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	RCA	8900204	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00060	Ubiquitin proteasome pathway	P01491	E2	ARATH|TAIR=AT3G46460|UniProtKB=Q42541	Ubiquitin-conjugating enzyme E2 13	ISS			PTHR24067:SF237	UBIQUITIN-CONJUGATING ENZYME E2 13-RELATED
P00029	Huntington disease	P00788	Calpain	CAEBR|Gene=CBG21580|UniProtKB=A8Y0F3	Protein CBR-TRA-3	ISS	11675509	PubMed	PTHR10183:SF281	CALPAIN-5
P05918	p38 MAPK pathway	P06018	MNK1	BOVIN|Gene=MKNK1|UniProtKB=Q58D94	MAP kinase-interacting serine/threonine-protein kinase 1	ISS	9155018	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00053	T cell activation	P01332	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00951	Jnk	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05913	Enkephalin release	P05977	G-Protein (s)	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	RAT|RGD=621005|UniProtKB=Q08849	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01375	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00012	Cadherin signaling pathway	P00465	TCF/LEF	MACMU|Ensembl=ENSMMUG00000023256|UniProtKB=F7HPX5	Uncharacterized protein	ISS	9039917	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00052	TGF-beta signaling pathway	P01284	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00047	PDGF signaling pathway	P01171	PLCgamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P06959	CCKR signaling map	P07077	CCK	HUMAN|HGNC=1569|UniProtKB=P06307	Cholecystokinin	RCA	12479974	PubMed	PTHR10786:SF0	CHOLECYSTOKININ
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00017	DNA replication	P00527	Histones	STRPU|EnsemblGenome=SPU_007637|UniProtKB=W4XW29	Histone H3	ISS	12413958	PubMed	PTHR11426:SF20	HISTONE H3-LIKE CENTROMERIC PROTEIN A
P06587	Nicotine pharmacodynamics pathway	P06599	EPB41L1	PANTR|Ensembl=ENSPTRG00000013455|UniProtKB=H2QKA1	Uncharacterized protein	ISS	12181426	PubMed	PTHR23280:SF24	BAND 4.1-LIKE PROTEIN 1
P00049	Parkinson disease	P01211	ERK	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	IDA	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MONDO|Ensembl=ENSMODG00000020204|UniProtKB=F6SED9	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00021	FGF signaling pathway	P00642	MEK1-2	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00859	NFkappaB	RAT|RGD=70498|UniProtKB=Q63369	Nuclear factor NF-kappa-B p105 subunit (Fragment)	ISS	12574369	PubMed	PTHR24169:SF9	NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	IC	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04393	Ras Pathway	P04558	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	TAS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	PSEAE|EnsemblGenome=PA5373|UniProtKB=Q9HTJ1	NAD/NADP-dependent betaine aldehyde dehydrogenase	IC			PTHR11699:SF115	NAD/NADP-DEPENDENT BETAINE ALDEHYDE DEHYDROGENASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00005	Angiogenesis	P00189	Fzd	MONDO|Ensembl=ENSMODG00000008701|UniProtKB=F6PWM3	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF22	FRIZZLED-3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	RCA	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00006	Apoptosis signaling pathway	P00318	PKCs	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	IGI	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04393	Ras Pathway	P04546	GSK3	RAT|RGD=620351|UniProtKB=P18265	Glycogen synthase kinase-3 alpha	IDA	2164470	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00019	Endothelin signaling pathway	P00591	PLCbeta	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IGI	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05913	Enkephalin release	P05977	G-Protein (s)	HUMAN|HGNC=4401|UniProtKB=O14775	Guanine nucleotide-binding protein subunit beta-5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02769	Purine metabolism	P03118	Guanine Deaminase	PANTR|Ensembl=ENSPTRG00000021020|UniProtKB=H2R3N5	Uncharacterized protein	ISS	7533042	gi	PTHR11271:SF6	GUANINE DEAMINASE
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000022548|UniProtKB=F6Y9J9	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00029	Huntington disease	P00799	JNK-2	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00018	EGF receptor signaling pathway	P00557	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS			PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00251	cPLA2	MACMU|Ensembl=ENSMMUG00000003842|UniProtKB=F7HAF3	Phospholipase A2	ISS	1709551	gi	PTHR10728:SF32	CYTOSOLIC PHOSPHOLIPASE A2 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	XENTR|Xenbase=XB-GENE-490534|UniProtKB=F7CQJ3	Uncharacterized protein (Fragment)	ISS	9230079	PubMed	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00034	Integrin signalling pathway	P00906	Rap1	ENTHI|EnsemblGenome=EHI_049030|UniProtKB=B1N4V4	Ras-like protein 3, putative	IPI	8576107	PubMed	PTHR24070:SF263	RAS-LIKE PROTEIN 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00015	Circadian clock system	P00501	Clock	MONDO|Ensembl=ENSMODG00000020678|UniProtKB=F7DL74	Uncharacterized protein	ISS	10198158	PubMed	PTHR23042:SF2	CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT
P00005	Angiogenesis	P00219	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00059	p53 pathway	P04633	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00011	Blood coagulation	P00418	Fibrin monomer	PANTR|Ensembl=ENSPTRG00000016534|UniProtKB=H2QQB4	Uncharacterized protein	ISS	11761631	gi	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MACMU|Ensembl=ENSMMUG00000008914|UniProtKB=F7DI64	Uncharacterized protein	ISS			PTHR13140:SF381	UNCONVENTIONAL MYOSIN-IG
P04393	Ras Pathway	P04542	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P06664	Gonadotropin-releasing hormone receptor pathway	P06768	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	RCA	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00010	B cell activation	P00384	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00012	Cadherin signaling pathway	P00474	Wnt	XENTR|Xenbase=XB-GENE-492636|UniProtKB=F7D1A1	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00029	Huntington disease	P00797	p53	MACMU|Ensembl=ENSMMUG00000016569|UniProtKB=F6VXE7	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	RAT|RGD=62010|UniProtKB=P34997	C-X-C chemokine receptor type 5	ISS	12101256	PubMed	PTHR10489:SF618	C-X-C CHEMOKINE RECEPTOR TYPE 5
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	ISS	8787761	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00642	MEK1-2	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	BOVIN|Ensembl=ENSBTAG00000009942|UniProtKB=E1BH60	Phosphoinositide phospholipase C	ISS			PTHR10336:SF84	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	TAS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	ANOGA|EnsemblGenome=AGAP001506|UniProtKB=Q7PXP3	AGAP001506-PA	IC			PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00019	Endothelin signaling pathway	P00566	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04657	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00048	PI3 kinase pathway	P01188	Gbetagamma	RAT|RGD=69319|UniProtKB=P54313	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00006	Apoptosis signaling pathway	P00297	NFkappaB	CHICK|Ensembl=ENSGALG00000012304|UniProtKB=Q04861	Nuclear factor NF-kappa-B p105 subunit	ISS	12574369	PubMed	PTHR24169:SF9	NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT
P00056	VEGF signaling pathway	P01415	MAPKAPK2/3	MACMU|Ensembl=ENSMMUG00000023567|UniProtKB=F7HHY8	Uncharacterized protein	ISS	9628873	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P05913	Enkephalin release	P05974	G-Protein (i)	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	MOUSE|MGI=MGI=87889|UniProtKB=Q2MKA5	Neuronal acetylcholine receptor subunit alpha-5	ISS	85270494	PubMed	PTHR18945:SF76	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	RAT|RGD=620351|UniProtKB=P18265	Glycogen synthase kinase-3 alpha	IDA	183955	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00004	Alzheimer disease-presenilin pathway	P00127	APP	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	ORYSJ|EnsemblGenome=OS01G0267900|UniProtKB=Q0JNS6	Calmodulin-1	ISS	9753452	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	BOVIN|Ensembl=ENSBTAG00000022000|UniProtKB=Q9MZL5	Voltage-dependent L-type calcium channel subunit beta-2	IDA	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P04396	Vitamin D metabolism and pathway	P04607	FDX	MOUSE|MGI=MGI=103224|UniProtKB=P46656	Adrenodoxin, mitochondrial	IDA	2969697	PubMed	PTHR23426:SF26	ADRENODOXIN, MITOCHONDRIAL
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P06959	CCKR signaling map	P07088	RYR1/2/3	HUMAN|HGNC=10485|UniProtKB=Q15413	Ryanodine receptor 3	RCA	16786171	PubMed	PTHR13715:SF16	RYANODINE RECEPTOR 3
P02766	Phenylethylamine degradation	P03103	Phenylethylamine oxidase	MOUSE|MGI=MGI=2668431|UniProtKB=Q812C9	Retina-specific copper amine oxidase	ISS			PTHR10638:SF4	RETINA-SPECIFIC COPPER AMINE OXIDASE
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P06587	Nicotine pharmacodynamics pathway	P06602	PPP1CA	PANTR|Ensembl=ENSPTRG00000005449|UniProtKB=H2Q6V7	Serine/threonine-protein phosphatase	ISS	10433257	PubMed	PTHR11668:SF377	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-ALPHA CATALYTIC SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01333	cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00019	Endothelin signaling pathway	P00589	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	20855874	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=7579|UniProtKB=P35579	Myosin-9	IC	89264452	PubMed	PTHR13140:SF317	MYOSIN-9
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00054	Toll receptor signaling pathway	P01375	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12676940	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00049	Parkinson disease	P01238	14-3-3	RAT|RGD=62000|UniProtKB=P62260	14-3-3 protein epsilon	ISS	9450960	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00057	Wnt signaling pathway	P01465	Ggamma	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	RAT|RGD=2740|UniProtKB=Q62645	Glutamate receptor ionotropic, NMDA 2D	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MACMU|Ensembl=ENSMMUG00000015717|UniProtKB=F6SFA9	Serotonin receptor type 1B	ISS	11701344	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01322	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	IGI	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01179	PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02725	Allantoin degradation	P02821	Allantoate amidohydrolase	STRCO|EnsemblGenome=CAB60167|UniProtKB=Q9RKU4	Probable allantoicase	ISS			PTHR12045:SF6	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01150	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00050	Plasminogen activating cascade	P01243	uPA	BOVIN|Ensembl=ENSBTAG00000005947|UniProtKB=Q05589	Urokinase-type plasminogen activator	ISS	465014	gi	PTHR24264:SF38	UROKINASE-TYPE PLASMINOGEN ACTIVATOR
P00021	FGF signaling pathway	P00629	PP2A	MACMU|Ensembl=ENSMMUG00000004873|UniProtKB=F7ANY9	Uncharacterized protein	ISS	96161994	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00057	Wnt signaling pathway	P01456	beta-arrestin	BOVIN|Ensembl=ENSBTAG00000021480|UniProtKB=P08168	S-arrestin	IC	11742073	PubMed	PTHR11792:SF15	S-ARRESTIN
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00629	PP2A	TAKRU|Ensembl=ENSTRUG00000011506|UniProtKB=H2TWI2	Serine/threonine-protein phosphatase	ISS			PTHR11668:SF22	SERINE/THREONINE-PROTEIN PHOSPHATASE 4 CATALYTIC SUBUNIT
P04395	Vasopressin synthesis	P04593	Glycopeptide	RAT|RGD=3238|UniProtKB=P01179	Oxytocin-neurophysin 1	IC	1706187	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00014	Cholesterol biosynthesis	P00491	Hydroxymethyl glutaryl CoA reductase	BOVIN|Ensembl=ENSBTAG00000007840|UniProtKB=A7Z064	3-hydroxy-3-methylglutaryl-coenzyme A reductase	ISS	Q29512	SPACC	PTHR10572:SF2	3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	MACMU|Ensembl=ENSMMUG00000014498|UniProtKB=F7GEI8	Uncharacterized protein	ISS	8386525	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MOUSE|MGI=MGI=95777|UniProtKB=Q6R0H7	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas	IC	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000004896|UniProtKB=F7C2C6	Uncharacterized protein (Fragment)	ISS	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	11035810	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00006	Apoptosis signaling pathway	P00322	Cytochrome C	DROME|FlyBase=FBgn0000409|UniProtKB=P84029	Cytochrome c-2	ISS			PTHR11961:SF12	CYTOCHROME C
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	IC	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00589	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	BOVIN|Ensembl=ENSBTAG00000017639|UniProtKB=F1MZW8	Ribosomal protein S6 kinase	ISS	10558991	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00029	Huntington disease	P00780	Microtubule	MACMU|Ensembl=ENSMMUG00000023785|UniProtKB=F7HTD6	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00014	Cholesterol biosynthesis	P00497	Anosterol synthase	SCHPO|PomBase=SPAC13G7.01c|UniProtKB=Q10231	Lanosterol synthase	ISS	P38604	SPACC	PTHR11764:SF20	LANOSTEROL SYNTHASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=94926|UniProtKB=P51436	D(4) dopamine receptor	IDA	1319557	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01171	PLCgamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00022	General transcription by RNA polymerase I	P00651	TAF-IA	CHICK|Ensembl=ENSGALG00000003498|UniProtKB=Q5ZMS1	Transcription initiation factor TFIID subunit 8	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00009	Axon guidance mediated by netrin	P00366	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	14564011	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00640	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=621025|UniProtKB=Q62711	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	12860966	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CHICK|Ensembl=ENSGALG00000014975|UniProtKB=F1NTE9	Uncharacterized protein	IDA			PTHR43893:SF8	D 1B  DOPAMINE RECEPTOR
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IGI	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00011	Blood coagulation	P00451	Kininogen	RAT|RGD=2980|UniProtKB=P08934	Kininogen-1	ISS	6981138	gi	PTHR13814:SF12	KININOGEN-1
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	HUMAN|HGNC=4594|UniProtKB=Q14416	Metabotropic glutamate receptor 2	ISS	12488551	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00018	EGF receptor signaling pathway	P00547	PP2A	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	88107662	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00568	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	15572354	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00249	PAK	XENTR|Xenbase=XB-GENE-961764|UniProtKB=F6W3Y0	Uncharacterized protein	ISS	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P05912	Dopamine receptor mediated signaling pathway	P05970	TH	MACMU|Ensembl=ENSMMUG00000003912|UniProtKB=F6ZV38	Uncharacterized protein	ISS	12480184	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	IDA	11889126	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P05916	Opioid prodynorphin pathway	P06002	G-protein	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	XENTR|Xenbase=XB-GENE-491902|UniProtKB=A9UMK9	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF46	ALPHA-CENTRACTIN
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	MYCTU|EnsemblGenome=Rv3048c|UniProtKB=P9WH71	Ribonucleoside-diphosphate reductase subunit beta nrdF2	ISS			PTHR23409:SF32	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT BETA
P00036	Interleukin signaling pathway	P00997	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	7680960	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=7567|UniProtKB=P12882	Myosin-1	IC	89264452	PubMed	PTHR13140:SF484	MYOSIN-1
P00047	PDGF signaling pathway	P01150	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00008	Axon guidance mediated by Slit/Robo	P00348	Robo	PANTR|Ensembl=ENSPTRG00000015118|UniProtKB=H2RD56	Uncharacterized protein	ISS			PTHR44096:SF1	ROUNDABOUT HOMOLOG 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IC	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	RAT|RGD=2739|UniProtKB=Q00961	Glutamate receptor ionotropic, NMDA 2C	ISS	11319238	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00036	Interleukin signaling pathway	P00976	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00048	PI3 kinase pathway	P01188	Gbetagamma	DROME|FlyBase=FBgn0004623|UniProtKB=P29829	Guanine nucleotide-binding protein subunit beta-2	ISS	10391901	PubMed	PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00020	FAS signaling pathway	P00616	Nuclear Lamin	CHICK|Gene=LMNB2|UniProtKB=P14732	Lamin-B2	TAS	11165516	PubMed	PTHR23239:SF152	LAMIN-B2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	IC	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P06664	Gonadotropin-releasing hormone receptor pathway	P06831	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	RCA	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	CHICK|Ensembl=ENSGALG00000001183|UniProtKB=Q789A6	Nonmuscle myosin heavy chain	ISS	89264452	PubMed	PTHR13140:SF328	MYOSIN-10
P02771	Pyrimidine Metabolism	P03131	5'-Nucleotidase	PANTR|Ensembl=ENSPTRG00000018391|UniProtKB=H2QTC9	5'-nucleotidase, ecto (CD73)	RCA	8224905	PubMed	PTHR11575:SF25	5'-NUCLEOTIDASE
P00029	Huntington disease	P00796	Kainate receptor	BOVIN|Ensembl=ENSBTAG00000011723|UniProtKB=E1BKL6	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00029	Huntington disease	P00807	Actin	CAEEL|WormBase=WBGene00000066|UniProtKB=P10986	Actin-4	IDA	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01242	Casein kinase I	XENTR|Xenbase=XB-GENE-481480|UniProtKB=Q5XGI6	Casein kinase 1, epsilon	ISS	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	HUMAN|HGNC=1401|UniProtKB=Q02641	Voltage-dependent L-type calcium channel subunit beta-1	ISS	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00053	T cell activation	P01311	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02730	Asparagine and aspartate biosynthesis	P02853	Asparagine synthetase	METJA|EnsemblGenome=MJ_1116|UniProtKB=Q58516	Putative asparagine synthetase [glutamine-hydrolyzing] 1	ISS			PTHR11772:SF2	ASPARAGINE SYNTHETASE
P00048	PI3 kinase pathway	P01182	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	P01430	p53	DANRE|ZFIN=ZDB-GENE-990415-270|UniProtKB=P79734	Cellular tumor antigen p53	IDA	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00057	Wnt signaling pathway	P01435	SWI/SNF	BOVIN|Ensembl=ENSBTAG00000009988|UniProtKB=Q5BIN2	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1	ISS	11532957	PubMed	PTHR10019:SF5	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY B MEMBER 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PHYPA|Gene=PHYPADRAFT_198730|UniProtKB=Q6TYS2	Actin 1	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	P01471	alpha-catenin	MONDO|Ensembl=ENSMODG00000012050|UniProtKB=F7ALE8	Uncharacterized protein	ISS	1904011	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00007	Axon guidance mediated by semaphorins	P00340	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	20010089	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04395	Vasopressin synthesis	P04590	Vasopressin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00049	Parkinson disease	P01227	20S proteasome	CANLF|Ensembl=ENSCAFG00000015287|UniProtKB=E2RKR4	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF10	PROTEASOME SUBUNIT ALPHA TYPE-3
P00006	Apoptosis signaling pathway	P00287	TNFR2	MACMU|Ensembl=ENSMMUG00000021447|UniProtKB=F7EAE4	Tumor necrosis factor receptor superfamily member 1B	ISS	11907583	PubMed	PTHR23097:SF120	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1B
P00059	p53 pathway	P04630	PP2A	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P05916	Opioid prodynorphin pathway	P06002	G-protein	MACMU|Ensembl=ENSMMUG00000010392|UniProtKB=F7ASR8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00029	Huntington disease	P00775	Rac	TAKRU|Ensembl=ENSTRUG00000013411|UniProtKB=H2UB84	Uncharacterized protein	ISS			PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00029	Huntington disease	P00786	ARF	CHICK|Ensembl=ENSGALG00000027757|UniProtKB=R4GGR6	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF139	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 4A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00005	Angiogenesis	P00243	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	IC	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00971	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8316835	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00021	FGF signaling pathway	P00646	RasGAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00036	Interleukin signaling pathway	P00996	STAT	XENTR|Xenbase=XB-GENE-5913743|UniProtKB=F6T2X3	Signal transducer and activator of transcription	ISS	11472851	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00034	Integrin signalling pathway	P00906	Rap1	CANLF|Ensembl=ENSCAFG00000000415|UniProtKB=E2R2K4	Uncharacterized protein	ISS	8576107	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	IDA	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00047	PDGF signaling pathway	P01153	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01236	Casein kinase II	MONDO|Ensembl=ENSMODG00000019523|UniProtKB=F6VCI6	Uncharacterized protein	ISS	10617630	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00053	T cell activation	P01306	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IDA	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P00006	Apoptosis signaling pathway	P00274	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00775	Rac	DROME|FlyBase=FBgn0010341|UniProtKB=P40793	Cdc42 homolog	TAS			PTHR24072:SF192	CDC42 HOMOLOG
P00034	Integrin signalling pathway	P00932	FAK	CHICK|Ensembl=ENSGALG00000016171|UniProtKB=Q00944	Focal adhesion kinase 1	IPI	12640026	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00048	PI3 kinase pathway	P01185	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	8925912	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00046	Oxidative stress response	P01131	MKP5	MONDO|Ensembl=ENSMODG00000004672|UniProtKB=F6U725	Uncharacterized protein	ISS	10597297	PubMed	PTHR10159:SF299	DUAL SPECIFICITY PROTEIN PHOSPHATASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=94925|UniProtKB=P30728	D(3) dopamine receptor	IDA	2039532	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	PANTR|Ensembl=ENSPTRG00000002062|UniProtKB=H2Q194	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	HUMAN|HGNC=17300|UniProtKB=Q7Z7C8	Transcription initiation factor TFIID subunit 8	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00029	Huntington disease	P00799	JNK-2	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00006	Apoptosis signaling pathway	P00297	NFkappaB	MOUSE|MGI=MGI=97312|UniProtKB=P25799	Nuclear factor NF-kappa-B p105 subunit	IDA	8598461	PubMed	PTHR24169:SF9	NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT
P00005	Angiogenesis	P00240	FRS-2	XENTR|Xenbase=XB-GENE-479760|UniProtKB=B5DE89	Frs2 protein	ISS	21826201	PubMed	PTHR21258:SF40	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04398	p53 pathway feedback loops 2	G04714	PTEN	XENTR|Xenbase=XB-GENE-491433|UniProtKB=B1H2U0	Pten protein	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P02757	O-antigen biosynthesis	P03045	dTDP-glucose 4,6-dehydratase	ORNAN|Ensembl=ENSOANG00000014920|UniProtKB=F6V878	Uncharacterized protein	ISS			PTHR43000:SF7	DTDP-D-GLUCOSE 4,6-DEHYDRATASE
P00057	Wnt signaling pathway	P01443	Phospholipase C	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04397	p53 pathway by glucose deprivation	P04641	Akt	XENTR|Xenbase=XB-GENE-484168|UniProtKB=B1WB72	Akt2 protein	ISS			PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01211	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00645	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00010	B cell activation	P00382	Syk	MACMU|Ensembl=ENSMMUG00000001748|UniProtKB=F7GLV6	Tyrosine-protein kinase	ISS	8137818	PubMed	PTHR24418:SF231	TYROSINE-PROTEIN KINASE SYK
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00056	VEGF signaling pathway	P01423	p38MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00047	PDGF signaling pathway	P01161	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	IC	176910	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05730	Endogenous cannabinoid signaling	P05751	Galpha	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00035	Interferon-gamma signaling pathway	P00956	SOCS	BOVIN|Ensembl=ENSBTAG00000008535|UniProtKB=E1BIS1	Uncharacterized protein	ISS	15032587	PubMed	PTHR45052:SF1	SUPPRESSOR OF CYTOKINE SIGNALING 7
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04440	Beta2	PANTR|Ensembl=ENSPTRG00000017391|UniProtKB=D3K5P1	Adrenergic, beta-2-, receptor, surface	ISS	12063255	PubMed	PTHR24248:SF21	BETA-2 ADRENERGIC RECEPTOR
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02738	De novo purine biosynthesis	P02907	dADP kinase	CAEBR|Gene=CBG02247|UniProtKB=A8WS68	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00591	PLCbeta	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00029	Huntington disease	P00811	Arp2/3 complex	RAT|RGD=2155|UniProtKB=O88656	Actin-related protein 2/3 complex subunit 1B	TAS	12963527	gi	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=1750|UniProtKB=P55287	Cadherin-11	IDA	8120095	PubMed	PTHR24027:SF85	CADHERIN-11
P00045	Notch signaling pathway	P01119	NIct	RAT|RGD=3187|UniProtKB=Q07008	Neurogenic locus notch homolog protein 1	IEP	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00036	Interleukin signaling pathway	P00981	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00015	Circadian clock system	P00504	Per	MACMU|Ensembl=ENSMMUG00000018930|UniProtKB=F6YLJ6	Uncharacterized protein	ISS	11232563	PubMed	PTHR11269:SF9	PERIOD CIRCADIAN PROTEIN HOMOLOG 2
P05731	GABA-B receptor II signaling	P05752	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01185	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00059	p53 pathway	P01486	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	1718748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01240	hSel10	BOVIN|Ensembl=ENSBTAG00000015376|UniProtKB=F1MLG0	Uncharacterized protein	ISS			PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P00029	Huntington disease	P00786	ARF	MACMU|Ensembl=ENSMMUG00000010846|UniProtKB=F7G3K5	ADP-ribosylation factor-like protein 4A	ISS	12932731	PubMed	PTHR11711:SF139	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 4A
P04398	p53 pathway feedback loops 2	P04668	p53	CANLF|Gene=TP53|UniProtKB=Q29537	Cellular tumor antigen p53	TAS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00057	Wnt signaling pathway	P01438	PP2A	BOVIN|Ensembl=ENSBTAG00000009245|UniProtKB=Q0P594	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	MONDO|Ensembl=ENSMODG00000006900|UniProtKB=F6PUU3	Uncharacterized protein	ISS			PTHR22952:SF97	CAMP-RESPONSIVE ELEMENT MODULATOR
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00053	T cell activation	P01336	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00206	Wnt	MACMU|Ensembl=ENSMMUG00000015705|UniProtKB=F6SM00	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	IDA	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00005	Angiogenesis	P00185	JAK1	DANRE|ZFIN=ZDB-GENE-980526-142|UniProtKB=O12990	Tyrosine-protein kinase JAK1	ISS	11929133	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00053	T cell activation	P01312	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01413	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00029	Huntington disease	P00805	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00796	Kainate receptor	MACMU|Ensembl=ENSMMUG00000017431|UniProtKB=F7HPP3	Uncharacterized protein	ISS	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00057	Wnt signaling pathway	P01444	Wnt	DANRE|ZFIN=ZDB-GENE-051129-1|UniProtKB=Q4JLT0	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00021	FGF signaling pathway	P00629	PP2A	DANRE|ZFIN=ZDB-GENE-050417-441|UniProtKB=Q567Y8	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	CANLF|Ensembl=ENSCAFG00000006694|UniProtKB=F1PR71	Uncharacterized protein	ISS			PTHR19957:SF36	SYNTAXIN-2
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00029	Huntington disease	P00786	ARF	CAEEL|WormBase=WBGene00000190|UniProtKB=Q94231	ADP-ribosylation factor 1-like 1	IPI	12932731	PubMed	PTHR11711:SF193	ADP-RIBOSYLATION FACTOR 1-LIKE 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00644	p38	CAEBR|Gene=CBG01555|UniProtKB=A8WRD7	Mitogen-activated protein kinase	ISS	11703092	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00034	Integrin signalling pathway	P00916	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02741	Flavin biosynthesis	P02935	GTP cyclohydrolase	SCHPO|PomBase=SPAP27G11.09c|UniProtKB=Q9P7M9	Probable GTP cyclohydrolase-2	ISS			PTHR21327:SF13	GTP CYCLOHYDROLASE-2
P00029	Huntington disease	P00779	TBP	HALSA|EnsemblGenome=VNG_2243G|UniProtKB=Q9HN56	TATA-box-binding protein E	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02746	Heme biosynthesis	P02975	Uroporphyrinogen decarboxylase	MOUSE|MGI=MGI=98916|UniProtKB=P70697	Uroporphyrinogen decarboxylase	ISS			PTHR21091:SF2	UROPORPHYRINOGEN DECARBOXYLASE
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00060	Ubiquitin proteasome pathway	P01494	19S proteasome	RAT|RGD=621102|UniProtKB=Q63570	26S protease regulatory subunit 6B	ISS			PTHR23073:SF8	26S PROTEASE REGULATORY SUBUNIT 6B
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	MACMU|Ensembl=ENSMMUG00000012422|UniProtKB=F7DJH4	Tyrosine-protein kinase receptor	ISS	10226785	PubMed	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00057	Wnt signaling pathway	P01446	Calcineurin	BOVIN|Ensembl=ENSBTAG00000016005|UniProtKB=P48452	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	IDA	12091710	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IDA	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IDA	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04393	Ras Pathway	P04546	GSK3	MOUSE|MGI=MGI=2152453|UniProtKB=Q2NL51	Glycogen synthase kinase-3 alpha	ISS	21361340	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P02738	De novo purine biosynthesis	P02909	GDP reductase	RAT|RGD=2323655|UniProtKB=D4A7M6	Protein LOC100359539	ISS			PTHR23409:SF20	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P05913	Enkephalin release	P05977	G-Protein (s)	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IDA	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00021	FGF signaling pathway	P00638	PLCgamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00029	Huntington disease	P00786	ARF	XENTR|Xenbase=XB-GENE-950251|UniProtKB=Q6NT85	ADP-ribosylation factor 1	ISS	12932731	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00029	Huntington disease	P00799	JNK-2	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00049	Parkinson disease	P01230	Src kinase	CANLF|Ensembl=ENSCAFG00000003995|UniProtKB=E2RC09	Tyrosine-protein kinase	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00220	c-Jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00475	Frizzled	MOUSE|MGI=MGI=108571|UniProtKB=Q9EQD0	Frizzled-5	IDA	11212302	PubMed	PTHR11309:SF126	FRIZZLED-5
P00006	Apoptosis signaling pathway	P00269	MAPK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01159	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8718|UniProtKB=Q9Y5F6	Protocadherin gamma-C5	IDA	8120095	PubMed	PTHR24028:SF234	PROTOCADHERIN GAMMA-C5
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ARATH|TAIR=AT2G42090|UniProtKB=P93738	Putative actin-9	IDA	14684598	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	RCA	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	CHICK|Ensembl=ENSGALG00000027629|UniProtKB=Q5ZJ03	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04393	Ras Pathway	P04558	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00049	Parkinson disease	P01211	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IDA	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00036	Interleukin signaling pathway	P00975	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00049	Parkinson disease	P01227	20S proteasome	CAEBR|Gene=CBG12349|UniProtKB=A8XFM4	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF15	PROTEASOME SUBUNIT ALPHA TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MOUSE|MGI=MGI=95686|UniProtKB=Q07104	Growth/differentiation factor 3	TAS	9759503	PubMed	PTHR11848:SF38	GROWTH/DIFFERENTIATION FACTOR 3
P02736	Coenzyme A biosynthesis	P02885	Pantothenate kinase	PANTR|Ensembl=ENSPTRG00000002738|UniProtKB=H2Q291	Uncharacterized protein	ISS			PTHR12280:SF23	PANTOTHENATE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	IDA	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01067	AChE	RAT|RGD=619996|UniProtKB=Q9JKC1	Carboxylic ester hydrolase	IC			PTHR43918:SF5	CHOLINESTERASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IDA	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	NEUCR|EnsemblGenome=EFNCRG00000003893|UniProtKB=P78711	Actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	MACMU|Ensembl=ENSMMUG00000010761|UniProtKB=F7FXK5	Uncharacterized protein	ISS	8679696	PubMed	PTHR11647:SF50	DIHYDROPYRIMIDINASE
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01026	KA	HUMAN|HGNC=4580|UniProtKB=Q13002	Glutamate receptor ionotropic, kainate 2	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00570	PKA	DICDI|dictyBase=DDB_G0283907|UniProtKB=P34099	cAMP-dependent protein kinase catalytic subunit	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P06587	Nicotine pharmacodynamics pathway	P06605	KCNK3/9	BOVIN|Ensembl=ENSBTAG00000018193|UniProtKB=E1BHX8	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	CANLF|Ensembl=ENSCAFG00000004381|UniProtKB=J9JH96	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TAKRU|Ensembl=ENSTRUG00000005447|UniProtKB=P68142	Actin, cytoplasmic 1	IC	10974003	PubMed	PTHR11937:SF354	SUBFAMILY NOT NAMED
P04397	p53 pathway by glucose deprivation	P04645	TSC1	RAT|RGD=620124|UniProtKB=Q9Z136	Hamartin	ISS	12167664	PubMed	PTHR15154:SF2	HAMARTIN
P00010	B cell activation	P00398	IP3R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00962	ELK	MOUSE|MGI=MGI=101762|UniProtKB=P41971	ETS domain-containing protein Elk-3	ISS			PTHR11849:SF172	ETS DOMAIN-CONTAINING PROTEIN ELK-3
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	BOVIN|Ensembl=ENSBTAG00000013631|UniProtKB=P15103	Glutamine synthetase	ISS			PTHR20852:SF45	GLUTAMINE SYNTHETASE
P04398	p53 pathway feedback loops 2	P04649	Myc	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	IC			PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00036	Interleukin signaling pathway	P00987	SRF	MACMU|Ensembl=ENSMMUG00000000033|UniProtKB=F7G4D2	Uncharacterized protein	ISS	15326221	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00029	Huntington disease	P00780	Microtubule	MONDO|Ensembl=ENSMODG00000024011|UniProtKB=F7CGM4	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P04398	p53 pathway feedback loops 2	P04661	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=12775|UniProtKB=O00744	Protein Wnt-10b	IDA	11266476	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00018	EGF receptor signaling pathway	P00545	JNK1-3	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000000440|UniProtKB=H2PYH8	Uncharacterized protein	ISS	11259487	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000002016|UniProtKB=F1P3G1	Protein kinase C delta type	IC	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00029	Huntington disease	P00771	Sin3A	PANTR|Ensembl=ENSPTRG00000007300|UniProtKB=H2R491	SIN3 homolog A, transcription regulator	ISS	10441327	PubMed	PTHR12346:SF2	PAIRED AMPHIPATHIC HELIX PROTEIN SIN3A
P00005	Angiogenesis	P00203	Erk	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00048	PI3 kinase pathway	P01194	S6K	MONDO|Ensembl=ENSMODG00000014313|UniProtKB=F7BTW0	Ribosomal protein S6 kinase	ISS	11861821	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MONDO|Ensembl=ENSMODG00000023429|UniProtKB=F6XI83	Uncharacterized protein	ISS	11701344	PubMed	PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P00034	Integrin signalling pathway	P00927	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00046	Oxidative stress response	P01135	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00647	SHP2	MACMU|Ensembl=ENSMMUG00000013253|UniProtKB=F6ZJD8	Tyrosine-protein phosphatase non-receptor type	ISS	8096088	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00021	FGF signaling pathway	P00636	FGFR1-4	DANRE|ZFIN=ZDB-GENE-980526-488|UniProtKB=Q90413	Fibroblast growth factor receptor 4	IEP	8589434	PubMed	PTHR24416:SF343	FIBROBLAST GROWTH FACTOR RECEPTOR 4
P00060	Ubiquitin proteasome pathway	P01490	E3	CANLF|Ensembl=ENSCAFG00000005158|UniProtKB=F1PB35	Uncharacterized protein	ISS			PTHR11254:SF357	UBIQUITIN-PROTEIN LIGASE E3C
P00015	Circadian clock system	G01497	cry	BOVIN|Ensembl=ENSBTAG00000010149|UniProtKB=F1MXB2	Uncharacterized protein	ISS	14507900	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00752	cGMP-gated ion channel	MACMU|Ensembl=ENSMMUG00000018340|UniProtKB=F7H666	Uncharacterized protein	ISS	12432397	PubMed	PTHR10217:SF386	CYCLIC NUCLEOTIDE-GATED CATION CHANNEL BETA-1
P00029	Huntington disease	P00790	beta-Tubulin	ORNAN|Ensembl=ENSOANG00000004061|UniProtKB=F6TYN8	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	IDA	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00045	Notch signaling pathway	P01116	Delta	RAT|RGD=619931|UniProtKB=O70534	Delta-like 1 homolog (Drosophila)	ISS			PTHR24052:SF11	PROTEIN DELTA HOMOLOG 1
P00029	Huntington disease	P00777	CBP	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	IDA	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	CHICK|Ensembl=ENSGALG00000026748|UniProtKB=F1P493	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF728	MYOSIN HEAVY CHAIN, SKELETAL MUSCLE, ADULT
P00010	B cell activation	P00379	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01444	Wnt	MACMU|Ensembl=ENSMMUG00000020809|UniProtKB=F7H7P8	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P06959	CCKR signaling map	P07220	A-Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	RCA	21810446	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CAEEL|WormBase=WBGene00004038|UniProtKB=Q22070	Phosphoinositide phospholipase C	ISS			PTHR10336:SF91	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00012	Cadherin signaling pathway	P00475	Frizzled	MONDO|Ensembl=ENSMODG00000008701|UniProtKB=F6PWM3	Uncharacterized protein	ISS	12549854	PubMed	PTHR11309:SF22	FRIZZLED-3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04451	CRHR1	HUMAN|HGNC=2357|UniProtKB=P34998	Corticotropin-releasing factor receptor 1	ISS	11145609	PubMed	PTHR12011:SF175	CORTICOTROPIN-RELEASING FACTOR RECEPTOR 1
P00047	PDGF signaling pathway	P01154	Ras	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	ISS	12104050	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	P01440	Cadherin	BOVIN|Ensembl=ENSBTAG00000011862|UniProtKB=G3X6Y5	Uncharacterized protein	ISS	8120095	PubMed	PTHR43912:SF7	PROTOCADHERIN-20
P00052	TGF-beta signaling pathway	P01279	Smurfs	MACMU|Ensembl=ENSMMUG00000009461|UniProtKB=F7A9B7	Uncharacterized protein	ISS	11252892	PubMed	PTHR11254:SF300	E3 UBIQUITIN-PROTEIN LIGASE SMURF2
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00211	GSK3beta	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05731	GABA-B receptor II signaling	P05752	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	RCA	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01449	Nemo-like Kinase	MACMU|Ensembl=ENSMMUG00000018719|UniProtKB=F6YC03	Mitogen-activated protein kinase	ISS	10683140	PubMed	PTHR24055:SF179	SERINE/THREONINE-PROTEIN KINASE NLK
P00053	T cell activation	P01333	cdc42	MACMU|Ensembl=ENSMMUG00000022009|UniProtKB=F6RBZ7	Cell division control protein 42 homolog isoform 2	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04392	P53 pathway feedback loops 1	P04536	Mdm2	DANRE|ZFIN=ZDB-GENE-990415-153|UniProtKB=O42354	E3 ubiquitin-protein ligase Mdm2	IGI	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DICPU|Gene=DICPUDRAFT_46519|UniProtKB=F0Z796	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00020	FAS signaling pathway	P00599	Caspase3	MOUSE|MGI=MGI=107739|UniProtKB=P70677	Caspase-3	ISS	9323209	PubMed	PTHR10454:SF198	CASPASE-3
P00034	Integrin signalling pathway	P00927	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	20010089	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00047	PDGF signaling pathway	P01153	GSK3	RAT|RGD=620351|UniProtKB=P18265	Glycogen synthase kinase-3 alpha	ISS	11995474	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00059	p53 pathway	P04630	PP2A	ANOGA|EnsemblGenome=AGAP010172|UniProtKB=Q7PD38	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	BOVIN|Ensembl=ENSBTAG00000019988|UniProtKB=F1N2V3	Uncharacterized protein	ISS	11534853	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P00015	Circadian clock system	G01501	cry	ARATH|TAIR=AT4G08920|UniProtKB=Q43125	Cryptochrome-1	ISS			PTHR11455:SF18	DEOXYRIBODIPYRIMIDINE PHOTO-LYASE, MITOCHONDRIAL
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	METAC|EnsemblGenome=MA_1919|UniProtKB=Q8TPJ2	Adenylosuccinate synthetase 1	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	IC	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04372	5-Hydroxytryptamine degredation	P04401	Monoamine Oxidase	MOUSE|MGI=MGI=96915|UniProtKB=Q64133	Amine oxidase [flavin-containing] A	ISS	90344230	PubMed	PTHR43563:SF3	AMINE OXIDASE  FLAVIN-CONTAINING  A
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8666|UniProtKB=Q9UN75	Protocadherin alpha-12	IDA	8120095	PubMed	PTHR24028:SF76	PROTOCADHERIN ALPHA-12
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00057	Wnt signaling pathway	P01456	beta-arrestin	DANRE|ZFIN=ZDB-GENE-060824-1|UniProtKB=C3PTE8	Beta-arrestin 1	ISS	9388255	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00053	T cell activation	P01312	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00036	Interleukin signaling pathway	P00962	ELK	MACMU|Ensembl=ENSMMUG00000001024|UniProtKB=F6XTS0	ETS domain-containing protein Elk-4 isoform a	ISS	11846562	PubMed	PTHR11849:SF21	ETS DOMAIN-CONTAINING PROTEIN ELK-4
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DICPU|Gene=DICPUDRAFT_48914|UniProtKB=F0ZK40	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF154	ACTIN-17-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	14744428	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P06211	BMP/activin signaling pathway-drosophila	P06255	TGFbetaR II	DROME|Gene=Dmel_CG7904|UniProtKB=A0A0B4KG59	Serine/threonine-protein kinase receptor	RCA	http://flybase.org/reports/FBgn0003169.html	Website	PTHR23255:SF70	SERINE/THREONINE-PROTEIN KINASE RECEPTOR
P04393	Ras Pathway	P04572	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IDA	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00005	Angiogenesis	P00229	SPK	MACMU|Ensembl=ENSMMUG00000022159|UniProtKB=F6XJ72	Sphingosine kinase 2 isoform a	ISS			PTHR12358:SF40	SPHINGOSINE KINASE 2
P00047	PDGF signaling pathway	P01143	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IDA	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014262|UniProtKB=F7BYS8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00029	Huntington disease	P00780	Microtubule	TRIVA|Gene=TVAG_034440|UniProtKB=A2EM81	Beta-tubulin, putative	IDA	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00050	Plasminogen activating cascade	P01250	MMP-13	MACMU|Ensembl=ENSMMUG00000004253|UniProtKB=F6YQ28	Uncharacterized protein	ISS	98180967	PubMed	PTHR10201:SF165	COLLAGENASE 3
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00053	T cell activation	P01295	vav	CANLF|Ensembl=ENSCAFG00000018590|UniProtKB=E2RGT8	Uncharacterized protein	ISS	14623913	PubMed	PTHR22826:SF112	PROTO-ONCOGENE VAV
P00021	FGF signaling pathway	P00638	PLCgamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00012	Cadherin signaling pathway	P00477	GSK3beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04454	CRF	DANRE|ZFIN=ZDB-GENE-041114-75|UniProtKB=A7LNS7	Corticotropin releasing factor	ISS	122560	OMIM	PTHR15035:SF9	CORTICOLIBERIN
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IDA	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00057	Wnt signaling pathway	P01428	Frizzled	XENTR|Xenbase=XB-GENE-480379|UniProtKB=Q6GL20	Frizzled homolog 10	ISS	8717036	PubMed	PTHR11309:SF86	FRIZZLED-10
P00054	Toll receptor signaling pathway	P01365	TAB1	MOUSE|MGI=MGI=1913763|UniProtKB=Q8CF89	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1	ISS	10838074	PubMed	PTHR13832:SF533	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1
P00010	B cell activation	P00376	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00010	B cell activation	P00367	NFAT	MACMU|Ensembl=ENSMMUG00000012657|UniProtKB=F7E7J1	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00036	Interleukin signaling pathway	P00964	p90RSK	MACMU|Ensembl=ENSMMUG00000022111|UniProtKB=F7H7W3	Ribosomal protein S6 kinase	ISS	12213813	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00053	T cell activation	P01305	Calmodulin	ANOGA|EnsemblGenome=AGAP010957|UniProtKB=Q7QGY7	AGAP010957-PA (Fragment)	ISS	7514101	PubMed	PTHR23050:SF245	AT16150P-RELATED
P05918	p38 MAPK pathway	P06021	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12912997	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	MACMU|Ensembl=ENSMMUG00000017921|UniProtKB=F7EDG8	Uncharacterized protein	ISS			PTHR23050:SF335	CALMODULIN, STRIATED MUSCLE
P00013	Cell cycle	P00480	Proteasome	SCHPO|PomBase=SPCC1682.10|UniProtKB=O74440	26S proteasome regulatory subunit rpn8	ISS	21848401	PubMed	PTHR10540:SF7	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7
P00053	T cell activation	P01330	IKK	RAT|RGD=1306661|UniProtKB=G3V926	Conserved helix-loop-helix ubiquitous kinase (Predicted)	ISS	12235208	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	IDA	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00048	PI3 kinase pathway	P01206	14-3-3	HUMAN|HGNC=12855|UniProtKB=P63104	14-3-3 protein zeta/delta	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	CHICK|Ensembl=ENSGALG00000001334|UniProtKB=F1NLV4	Uncharacterized protein	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00029	Huntington disease	P00811	Arp2/3 complex	MACMU|Ensembl=ENSMMUG00000019342|UniProtKB=F6PVY4	Uncharacterized protein	ISS	12932731	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00056	VEGF signaling pathway	P01423	p38MAPK	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00036	Interleukin signaling pathway	P00968	Ikk	RAT|RGD=1306661|UniProtKB=G3V926	Conserved helix-loop-helix ubiquitous kinase (Predicted)	ISS	9346484	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00589	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00045	Notch signaling pathway	P01103	Next	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P02788	Xanthine and guanine salvage pathway	P03247	Xanthine phosphoribosyl transferase	CAEBR|Gene=CBG19800|UniProtKB=A8XWA1	Protein CBG19800	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00022	General transcription by RNA polymerase I	P00652	RNA Polymerase I  Complex	PANTR|Ensembl=ENSPTRG00000012366|UniProtKB=H2R8N5	DNA-directed RNA polymerase subunit beta	ISS	15691654	PubMed	PTHR20856:SF5	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA2
P04393	Ras Pathway	P04558	p38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IDA	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00030	Hypoxia response via HIF activation	P00819	AKT	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	TAS	12719720	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04623	CBP	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00048	PI3 kinase pathway	P01177	P110ACT	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00053	T cell activation	P01295	vav	MONDO|Ensembl=ENSMODG00000002796|UniProtKB=F7EJL2	Uncharacterized protein	ISS	14623913	PubMed	PTHR22826:SF97	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3
P00029	Huntington disease	P00807	Actin	MACMU|Ensembl=ENSMMUG00000017683|UniProtKB=F6UA63	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P04398	p53 pathway feedback loops 2	P04667	p21	MOUSE|MGI=MGI=104556|UniProtKB=P39689	Cyclin-dependent kinase inhibitor 1	IGI	7774811	PubMed	PTHR10265:SF16	CYCLIN-DEPENDENT KINASE INHIBITOR 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00006	Apoptosis signaling pathway	P00269	MAPK	ORYSJ|EnsemblGenome=OS03G0285800|UniProtKB=Q10N20	Mitogen-activated protein kinase 5	ISS	12787066	PubMed	PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IDA	3755548	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	MOUSE|MGI=MGI=87886|UniProtKB=Q91X60	Neuronal acetylcholine receptor subunit alpha-2	ISS	85270494	PubMed	PTHR18945:SF757	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-2
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	CHICK|Gene=ADCY9|UniProtKB=Q9DGG6	Adenylate cyclase type 9	IGI	21222856	PubMed	PTHR11920:SF319	ADENYLATE CYCLASE TYPE 9
P00046	Oxidative stress response	P01131	MKP5	MONDO|Ensembl=ENSMODG00000024437|UniProtKB=F7DK42	Uncharacterized protein	ISS			PTHR10159:SF338	DUAL SPECIFICITY PROTEIN PHOSPHATASE 14
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	ORNAN|Ensembl=ENSOANG00000005936|UniProtKB=F6PQC9	Uncharacterized protein	ISS	1904317	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00029	Huntington disease	G01529	Proline oxidase	DROME|FlyBase=FBgn0003423|UniProtKB=Q04499	Proline dehydrogenase 1, mitochondrial	NAS			PTHR13914:SF0	PROLINE DEHYDROGENASE 1, MITOCHONDRIAL
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P02738	De novo purine biosynthesis	P02898	Phosphoribosylformylglycinamide  synthase	YEAST|SGD=S000003293|UniProtKB=P38972	Phosphoribosylformylglycinamidine synthase	ISS			PTHR10099:SF1	PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE
P02777	Succinate to proprionate conversion	P03163	Methylmalonyl-CoA decarboxylase	HALSA|EnsemblGenome=VNG_1529G|UniProtKB=Q9HPQ0	Methylmalonyl-CoA decarboxylase, subunit alpha	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P00006	Apoptosis signaling pathway	P00303	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P02759	Pyridoxal-5-phosphate biosynthesis	P03061	Pyridoxine-5-phosphate oxidase	CANLF|Ensembl=ENSCAFG00000016814|UniProtKB=E2QTE2	Uncharacterized protein	ISS	14697241	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00053	T cell activation	P01332	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	IDA	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00007	Axon guidance mediated by semaphorins	P00340	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00009	Axon guidance mediated by netrin	P00364	cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	PANTR|Ensembl=ENSPTRG00000006342|UniProtKB=H2Q8A8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00029	Huntington disease	P00807	Actin	HUMAN|HGNC=169|UniProtKB=P61160	Actin-related protein 2	IDA	10974003	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00054	Toll receptor signaling pathway	P01346	TLR	MOUSE|MGI=MGI=1341296|UniProtKB=Q9EPW9	Toll-like receptor 6	ISS			PTHR24365:SF422	TOLL-LIKE RECEPTOR 6
P00018	EGF receptor signaling pathway	P00562	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00046	Oxidative stress response	P01124	Myc	HUMAN|HGNC=7553|UniProtKB=P01106	Myc proto-oncogene protein	TAS	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	IC	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05970	TH	MOUSE|MGI=MGI=98735|UniProtKB=P24529	Tyrosine 3-monooxygenase	ISS	12480184	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06831	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	RCA	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00021	FGF signaling pathway	P00637	MKK4,7	DROME|FlyBase=FBgn0024326|UniProtKB=O61444	MAP kinase kinase 4, isoform A	NAS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IC	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Gene=PCDHB11|UniProtKB=Q5DRD8	Protocadherin beta-11	ISS	8120095	PubMed	PTHR24028:SF91	PROTOCADHERIN BETA-11
P00036	Interleukin signaling pathway	P00979	MAPKAPK2	MOUSE|MGI=MGI=109298|UniProtKB=P49138	MAP kinase-activated protein kinase 2	IC	14672329	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00029	Huntington disease	P00778	NMDA receptor	RAT|RGD=2738|UniProtKB=Q00960	Glutamate receptor ionotropic, NMDA 2B	IDA	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CHICK|Ensembl=ENSGALG00000011809|UniProtKB=F1NMB0	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04397	p53 pathway by glucose deprivation	P04640	p53	MOUSE|MGI=MGI=1336991|UniProtKB=Q9JJP2	Tumor protein p73	TAS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	BOVIN|Ensembl=ENSBTAG00000012687|UniProtKB=F1MV64	Tyrosine-protein kinase receptor	ISS	14500580	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P00005	Angiogenesis	P00245	Rac	MOUSE|MGI=MGI=1924714|UniProtKB=Q812A5	Proline-rich protein 5	ISS			PTHR32428:SF4	PROLINE-RICH PROTEIN 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02736	Coenzyme A biosynthesis	P02884	Dephospho-CoA kinase	SCHPO|PomBase=SPCC14G10.01|UniProtKB=O74414	Uncharacterized protein C14G10.01	ISS			PTHR10695:SF35	DEPHOSPHO-COA KINASE DOMAIN-CONTAINING PROTEIN
P00019	Endothelin signaling pathway	P00572	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00034	Integrin signalling pathway	P00925	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00034	Integrin signalling pathway	P00906	Rap1	CHICK|Ensembl=ENSGALG00000009927|UniProtKB=Q5ZHX1	Ras-related protein Rap-1b	ISS	10476970	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00008	Axon guidance mediated by Slit/Robo	P00351	Cxcr4	CHICK|Ensembl=ENSGALG00000012357|UniProtKB=F1NAF4	Uncharacterized protein	ISS	4503175	gi	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P00018	EGF receptor signaling pathway	P00562	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	12810719	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	BOVIN|Ensembl=ENSBTAG00000003075|UniProtKB=E1BK34	Uncharacterized protein	ISS	11212302	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P00005	Angiogenesis	P00223	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01357	MEKK1	RAT|RGD=620966|UniProtKB=Q62925	Mitogen-activated protein kinase kinase kinase 1	ISS	12168099	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P04393	Ras Pathway	P04567	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00562	p38	DANRE|ZFIN=ZDB-GENE-990415-257|UniProtKB=O42376	Mitogen-activated protein kinase 12	ISS	10851062	PubMed	PTHR24055:SF339	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00057	Wnt signaling pathway	P01458	Protein Kinase C	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CANLF|Ensembl=ENSCAFG00000004381|UniProtKB=J9JH96	Uncharacterized protein	ISS	14614461	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00053	T cell activation	P01309	fos	CANLF|Ensembl=ENSCAFG00000017040|UniProtKB=E2QYK5	Uncharacterized protein	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00025	Hedgehog signaling pathway	P00682	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00188	Ets	MONDO|Ensembl=ENSMODG00000004730|UniProtKB=F6Y1Z2	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04393	Ras Pathway	P04546	GSK3	CANLF|Ensembl=ENSCAFG00000004882|UniProtKB=F1PAE3	Uncharacterized protein	ISS	12086949	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	MACMU|Ensembl=ENSMMUG00000001060|UniProtKB=F6QN17	Uncharacterized protein	ISS	8930069	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00010	B cell activation	P00402	Jnk	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00021	FGF signaling pathway	P00638	PLCgamma	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CANLF|Ensembl=ENSCAFG00000004930|UniProtKB=E2RFB5	Uncharacterized protein	ISS	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00034	Integrin signalling pathway	P00926	GRAF	MONDO|Ensembl=ENSMODG00000010362|UniProtKB=F6TVC2	Uncharacterized protein	ISS	8649427	PubMed	PTHR12552:SF4	RHO GTPASE-ACTIVATING PROTEIN 26
P04398	p53 pathway feedback loops 2	P04657	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00627	ERK1-2	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00054	Toll receptor signaling pathway	P01375	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	ISS	7600581	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IGI	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04398	p53 pathway feedback loops 2	P04665	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	IC	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MACMU|Ensembl=ENSMMUG00000006200|UniProtKB=F7HNS7	Receptor protein serine/threonine kinase	ISS	10683140	PubMed	PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	HUMAN|HGNC=4388|UniProtKB=P38405	Guanine nucleotide-binding protein G(olf) subunit alpha	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00049	Parkinson disease	P01213	Cyclin E	MOUSE|MGI=MGI=1329034|UniProtKB=Q9Z238	G1/S-specific cyclin-E2	IDA	12628165	PubMed	PTHR10177:SF70	G1/S-SPECIFIC CYCLIN-E2
P00017	DNA replication	P00529	RFC	RAT|RGD=1310142|UniProtKB=B4F778	Protein Rfc4	RCA			PTHR11669:SF20	REPLICATION FACTOR C SUBUNIT 4
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IDA	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00107	kinesin	CANLF|Ensembl=ENSCAFG00000004502|UniProtKB=E2RN88	Uncharacterized protein	ISS	11740561	PubMed	PTHR19959:SF125	KINESIN LIGHT CHAIN 3
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	PANTR|Ensembl=ENSPTRG00000014365|UniProtKB=H2R0C8	Casein kinase 1, epsilon	ISS	11865049	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	IC	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05960	VAT2	HUMAN|HGNC=10935|UniProtKB=Q05940	Synaptic vesicular amine transporter	IC	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	ARATH|TAIR=AT4G28540|UniProtKB=Q8LPJ1	Casein kinase 1-like protein 6	IDA	10617630	PubMed	PTHR11909:SF114	ADK1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00060	Ubiquitin proteasome pathway	P01491	E2	BRAFL|Gene=BRAFLDRAFT_128294|UniProtKB=C3ZMI7	Putative uncharacterized protein	ISS			PTHR43898:SF1	UBIQUITIN-CONJUGATING ENZYME E2-17 KDA
P05918	p38 MAPK pathway	P06020	p38delta	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01286	TGFbeta	PANTR|Ensembl=ENSPTRG00000011021|UniProtKB=H2QGE0	Transforming growth factor, beta 1	ISS	9759503	PubMed	PTHR11848:SF125	TRANSFORMING GROWTH FACTOR BETA-1
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	HUMAN|HGNC=3023|UniProtKB=P14416	D(2) dopamine receptor	ISS	2039532	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	HUMAN|HGNC=13718|UniProtKB=P15407	Fos-related antigen 1	ISS	10664585	PubMed	PTHR23351:SF6	FOS-RELATED ANTIGEN 1
P02751	Lysine biosynthesis	P03011	N-succinyldiaminopimelate  aminotransferase	MYCTU|EnsemblGenome=Rv1655|UniProtKB=P9WPZ7	Acetylornithine aminotransferase	ISS			PTHR11986:SF79	ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01005	NR2D	HUMAN|HGNC=4588|UniProtKB=O15399	Glutamate receptor ionotropic, NMDA 2D	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	TAS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00059	p53 pathway	G04694	p110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00054	Toll receptor signaling pathway	P01368	MKK2	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PANTR|Ensembl=ENSPTRG00000018890|UniProtKB=Q5R1X3	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P02738	De novo purine biosynthesis	P02889	dGDP kinase	ORYSJ|EnsemblGenome=OS10G0563700|UniProtKB=Q7XC37	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00053	T cell activation	P01331	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	AQUAE|EnsemblGenome=aq_728|UniProtKB=O66940	Ornithine decarboxylase	ISS			PTHR11482:SF6	ORNITHINE DECARBOXYLASE 1-RELATED
P00053	T cell activation	P01312	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	CAEBR|Gene=CBG02059|UniProtKB=A8WRW6	Protein CBR-UNC-2 (Fragment)	ISS	14624853	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CAEEL|WormBase=WBGene00006454|UniProtKB=G5EEN8	AEX-4	ISS			PTHR19305:SF10	AEX-4
P00005	Angiogenesis	P00219	PKC	MONDO|Ensembl=ENSMODG00000008318|UniProtKB=F7FGD2	Serine/threonine-protein kinase	ISS	12676944	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P05913	Enkephalin release	P05971	CREB	CHICK|Ensembl=ENSGALG00000008494|UniProtKB=Q7SX83	CAMP response element-binding protein	ISS	1354612	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P05918	p38 MAPK pathway	P06041	Cdc42	CHICK|Ensembl=ENSGALG00000004796|UniProtKB=Q90694	Cell division control protein 42 homolog	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00052	TGF-beta signaling pathway	P01284	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	ISS	15313841	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00189	Fzd	HUMAN|HGNC=4043|UniProtKB=Q13467	Frizzled-5	ISS	8717036	PubMed	PTHR11309:SF126	FRIZZLED-5
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	DANRE|ZFIN=ZDB-GENE-040718-134|UniProtKB=Q6DH55	Guanine nucleotide binding protein (G protein), beta polypeptide 3, like	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P05914	Nicotine degradation	P05981	INMT	HUMAN|HGNC=6069|UniProtKB=O95050	Indolethylamine N-methyltransferase	TAS			PTHR10867:SF6	INDOLETHYLAMINE N-METHYLTRANSFERASE-RELATED
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00053	T cell activation	P01311	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01438	PP2A	BOVIN|Ensembl=ENSBTAG00000020192|UniProtKB=A4FV55	PPP2R5C protein	ISS	10092233	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P00036	Interleukin signaling pathway	P00970	Interleukin	HUMAN|HGNC=6029|UniProtKB=P15248	Interleukin-9	IC			PTHR16926:SF1	INTERLEUKIN-9
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00057	Wnt signaling pathway	P01451	Galpha	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IDA	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00029	Huntington disease	P00770	N-CoR	BOVIN|Ensembl=ENSBTAG00000013271|UniProtKB=F1MGM4	Uncharacterized protein	ISS	10441327	PubMed	PTHR13992:SF5	NUCLEAR RECEPTOR COREPRESSOR 1
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04569	Cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00006	Apoptosis signaling pathway	P00314	MKK3	ORNAN|Ensembl=ENSOANG00000007732|UniProtKB=F6PXH5	Uncharacterized protein (Fragment)	ISS	11971971	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00115	Nicastrin	ARATH|TAIR=AT3G52640|UniProtKB=Q8GUM5	Nicastrin	IDA	10993067	PubMed	PTHR21092:SF0	NICASTRIN
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00047	PDGF signaling pathway	P01162	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00048	PI3 kinase pathway	P01185	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05941	GRK3	HUMAN|HGNC=290|UniProtKB=P35626	Beta-adrenergic receptor kinase 2	RCA	10852916	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00036	Interleukin signaling pathway	P00966	mTOR	MONDO|Ensembl=ENSMODG00000011138|UniProtKB=F7BA89	Uncharacterized protein	ISS	14526383	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00047	PDGF signaling pathway	P01143	ERK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	MOUSE|MGI=MGI=1351340|UniProtKB=Q9QYS2	Metabotropic glutamate receptor 3	ISS	20012997	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00015	Circadian clock system	G01497	cry	ORYSJ|EnsemblGenome=OS02G0573200|UniProtKB=Q6YXC2	Cryptochrome 1a	ISS			PTHR11455:SF18	DEOXYRIBODIPYRIMIDINE PHOTO-LYASE, MITOCHONDRIAL
P00019	Endothelin signaling pathway	P00568	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00199	JNKK1	MOUSE|MGI=MGI=1346869|UniProtKB=P47809	Dual specificity mitogen-activated protein kinase kinase 4	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00049	Parkinson disease	P01242	Casein kinase I	DROME|FlyBase=FBgn0002413|UniProtKB=O76324	Discs overgrown protein kinase	IDA	14712927	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00052	TGF-beta signaling pathway	P01275	P38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	12810719	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00029	Huntington disease	P00790	beta-Tubulin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g229095|UniProtKB=A7S027	Predicted protein	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00029	Huntington disease	P00807	Actin	RAT|RGD=2025|UniProtKB=P68136	Actin, alpha skeletal muscle	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00054	Toll receptor signaling pathway	P01352	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	CAEEL|WormBase=WBGene00001052|UniProtKB=Q86ME6	DOPamine receptor	ISS	15328036	PubMed	PTHR24247:SF114	5-HYDROXYTRYPTAMINE RECEPTOR 6
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	CHICK|Ensembl=ENSGALG00000017238|UniProtKB=F1NWG3	Uncharacterized protein	ISS	92317054	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P05731	GABA-B receptor II signaling	P05754	Ggamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	RCA	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P02738	De novo purine biosynthesis	P02898	Phosphoribosylformylglycinamide  synthase	DEIRA|EnsemblGenome=DR_0222|UniProtKB=Q9RXT4	Phosphoribosylformylglycinamidine synthase subunit PurL	ISS			PTHR43555:SF1	SUBFAMILY NOT NAMED
P05915	Opioid proenkephalin pathway	P05991	Enkephalin	RAT|RGD=68946|UniProtKB=P04094	Proenkephalin-A	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00046	Oxidative stress response	P01123	Bcl-2	MACMU|Ensembl=ENSMMUG00000006577|UniProtKB=F7HPT9	Uncharacterized protein	ISS	2250705	PubMed	PTHR11256:SF11	APOPTOSIS REGULATOR BCL-2
P00053	T cell activation	P01304	Csk	CHICK|Gene=CSK|UniProtKB=P41239	Tyrosine-protein kinase CSK	IDA	7687537	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01335	jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	8837781	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P05913	Enkephalin release	G06046	preproenkephalin mRNA	MACMU|Ensembl=ENSMMUG00000009984|UniProtKB=F6R267	Beta-neoendorphin-dynorphin	ISS	131330	OMIM	PTHR11438:SF4	PROENKEPHALIN-B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=8154|UniProtKB=P41145	Kappa-type opioid receptor	IDA	11259498	PubMed	PTHR24229:SF1	KAPPA-TYPE OPIOID RECEPTOR
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00182	p38MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00060	Ubiquitin proteasome pathway	P01490	E3	CANLF|Ensembl=ENSCAFG00000008784|UniProtKB=E2RSE2	E3 ubiquitin-protein ligase	ISS			PTHR11254:SF299	NEDD4-LIKE E3 UBIQUITIN-PROTEIN LIGASE WWP1
P00021	FGF signaling pathway	P00634	MEKK1-5	HUMAN|HGNC=6856|UniProtKB=Q9Y6R4	Mitogen-activated protein kinase kinase kinase 4	IGI	602425	OMIM	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	1650351	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MONDO|Ensembl=ENSMODG00000008180|UniProtKB=F7E4E2	Uncharacterized protein (Fragment)	ISS	89264452	PubMed	PTHR13140:SF328	MYOSIN-10
P00005	Angiogenesis	P00181	SHP2	MACMU|Ensembl=ENSMMUG00000013253|UniProtKB=F6ZJD8	Tyrosine-protein phosphatase non-receptor type	ISS	1382983	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00541	Spry	CANLF|Ensembl=ENSCAFG00000006250|UniProtKB=F1Q4C2	Uncharacterized protein	ISS	12027893	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P00003	Alzheimer disease-amyloid secretase pathway	P00093	Tip60	HUMAN|HGNC=579|UniProtKB=Q99767	Amyloid beta A4 precursor protein-binding family A member 2	IC			PTHR12345:SF12	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 2
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	RAT|RGD=3425|UniProtKB=P97887	Presenilin-1	TAS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	DROME|FlyBase=FBgn0001105|UniProtKB=P26308	Guanine nucleotide-binding protein subunit beta-1	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	CANLF|Ensembl=ENSCAFG00000001622|UniProtKB=E2RN76	Uncharacterized protein	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	DANRE|ZFIN=ZDB-GENE-040426-2487|UniProtKB=Q803G3	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MONDO|Ensembl=ENSMODG00000008886|UniProtKB=F7BS20	Uncharacterized protein	ISS			PTHR13140:SF341	UNCONVENTIONAL MYOSIN-IE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01087	CAT	MACMU|Ensembl=ENSMMUG00000004692|UniProtKB=F6RM01	Uncharacterized protein	ISS	97225904	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P00018	EGF receptor signaling pathway	P00564	Rac	DICDI|dictyBase=DDB_G0268622|UniProtKB=P34145	Rho-related protein rac1B	IGI	4757952	gi	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00036	Interleukin signaling pathway	P00990	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	8457205	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01238	14-3-3	PANTR|Ensembl=ENSPTRG00000011641|UniProtKB=H2QHF1	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	ISS	10407019	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P00048	PI3 kinase pathway	P01182	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00048	PI3 kinase pathway	P01202	p85	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IDA	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00025	Hedgehog signaling pathway	P00699	Su(fu)	ANOGA|EnsemblGenome=AGAP001948|UniProtKB=Q7PYI0	Suppressor of fused homolog	ISS			PTHR10928:SF2	SUPPRESSOR OF FUSED HOMOLOG
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_116948|UniProtKB=C3YKS6	Putative uncharacterized protein	ISS			PTHR11937:SF359	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00640	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	CHICK|Gene=PSEN2|UniProtKB=Q90X07	Presenilin-2	TAS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01312	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IDA	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	MACMU|Ensembl=ENSMMUG00000021843|UniProtKB=F6RNI3	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00004	Alzheimer disease-presenilin pathway	P00128	Erb-B4	CHICK|Ensembl=ENSGALG00000003126|UniProtKB=F1P258	Receptor protein-tyrosine kinase	ISS	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00020	FAS signaling pathway	P00615	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04393	Ras Pathway	P04570	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00586	Gq	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P06959	CCKR signaling map	P07228	MAPK1/3	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	RCA	12184814	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT1G59580|UniProtKB=Q39022	Mitogen-activated protein kinase 2	ISS	11707292	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P05731	GABA-B receptor II signaling	P05760	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00747	Rhodopsin	DROME|FlyBase=FBgn0019940|UniProtKB=O01668	Opsin Rh6	IDA	1634520	PubMed	PTHR24240:SF85	OPSIN RH1-RELATED
P00057	Wnt signaling pathway	P01446	Calcineurin	CANLF|Ensembl=ENSCAFG00000014818|UniProtKB=E2RJ59	Serine/threonine-protein phosphatase	ISS	7532676	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00474	Wnt	PANTR|Ensembl=ENSPTRG00000001108|UniProtKB=H2PZP0	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00048	PI3 kinase pathway	P01176	JAK	MONDO|Ensembl=ENSMODG00000015373|UniProtKB=F6WH53	Tyrosine-protein kinase	ISS	22482294	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00054	Toll receptor signaling pathway	P01367	MKK3	RAT|RGD=1306620|UniProtKB=B1H230	Map2k3 protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=5300|UniProtKB=P47898	5-hydroxytryptamine receptor 5A	IDA	12181435	PubMed	PTHR24247:SF108	5-HYDROXYTRYPTAMINE RECEPTOR 5A
P00023	General transcription regulation	P00660	RNA Polymerase II	ARATH|TAIR=AT5G09920|UniProtKB=O48890	DNA-directed RNA polymerase II subunit 4	ISS			PTHR21297:SF0	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB4
P00036	Interleukin signaling pathway	P00987	SRF	MONDO|Ensembl=ENSMODG00000018981|UniProtKB=F7FP88	Uncharacterized protein	ISS	15326221	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00034	Integrin signalling pathway	P00907	ERK	CHICK|Ensembl=ENSGALG00000004690|UniProtKB=Q5F3W3	Mitogen-activated protein kinase 6	ISS	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00047	PDGF signaling pathway	P01153	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00054	Toll receptor signaling pathway	P01369	MKK1	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MOUSE|MGI=MGI=95689|UniProtKB=P43028	Growth/differentiation factor 6	TAS	9759503	PubMed	PTHR11848:SF43	GROWTH/DIFFERENTIATION FACTOR 6
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	IC	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00021	FGF signaling pathway	P00645	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12676940	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	RAT|RGD=3425|UniProtKB=P97887	Presenilin-1	IDA	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00008	Axon guidance mediated by Slit/Robo	P00351	Cxcr4	PANTR|Ensembl=ENSPTRG00000012501|UniProtKB=P61072	C-X-C chemokine receptor type 4	ISS	11591799	PubMed	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P00034	Integrin signalling pathway	P00951	Jnk	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	CHICK|Gene=MYH3|UniProtKB=P02565	Myosin-1B	ISS	10938134	PubMed	PTHR13140:SF657	MYOSIN-4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05941	GRK3	MACMU|Ensembl=ENSMMUG00000023790|UniProtKB=F7HT93	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P05917	Opioid proopiomelanocortin pathway	P06010	proopiomelanocortin	MONDO|Ensembl=ENSMODG00000015853|UniProtKB=Q95J84	Proopiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00057	Wnt signaling pathway	P01437	TCF	MOUSE|MGI=MGI=1202879|UniProtKB=Q924A0	Transcription factor 7-like 2	IDA	12356903	PubMed	PTHR10373:SF32	TRANSCRIPTION FACTOR 7-LIKE 2
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MONDO|Ensembl=ENSMODG00000025248|UniProtKB=F7F5X1	Uncharacterized protein	ISS	9869449	PubMed	PTHR24070:SF186	GTPASE KRAS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IC	7492337	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	IC	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00057	Wnt signaling pathway	P01454	betaTrCP	MOUSE|MGI=MGI=2144023|UniProtKB=Q5SRY7	F-box/WD repeat-containing protein 11	IDA	10074433	PubMed	PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00057	Wnt signaling pathway	P01465	Ggamma	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00008	Axon guidance mediated by Slit/Robo	P00348	Robo	MOUSE|MGI=MGI=1274781|UniProtKB=O89026	Roundabout homolog 1	ISS			PTHR44096:SF1	ROUNDABOUT HOMOLOG 1
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01238	14-3-3	PANTR|Ensembl=ENSPTRG00000008521|UniProtKB=G2HI54	14-3-3 protein epsilon	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	10693759	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00018	EGF receptor signaling pathway	P00551	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00053	T cell activation	P01295	vav	PANTR|Ensembl=ENSPTRG00000001024|UniProtKB=H2PZI8	Uncharacterized protein	ISS	14623913	PubMed	PTHR22826:SF97	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	BOVIN|Ensembl=ENSBTAG00000007909|UniProtKB=F1MPE9	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00029	Huntington disease	P00780	Microtubule	MONDO|Ensembl=ENSMODG00000016603|UniProtKB=F6ZCX3	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF112	TUBULIN BETA-1 CHAIN
P02738	De novo purine biosynthesis	P02892	5-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase	BACSU|EnsemblGenome=BSU06440|UniProtKB=P12047	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P00005	Angiogenesis	P00214	HIF-1	BOVIN|Gene=HIF1A|UniProtKB=Q9XTA5	Hypoxia-inducible factor 1-alpha	ISS	14526383	PubMed	PTHR23043:SF7	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01443	Phospholipase C	CAEEL|WormBase=WBGene00004037|UniProtKB=Q9XWB7	Phosphoinositide phospholipase C	IDA	12176394	PubMed	PTHR10336:SF9	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00021	FGF signaling pathway	P00644	p38	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	IGI	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=109356|UniProtKB=O09044	Synaptosomal-associated protein 23	IC	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	TAS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00005	Angiogenesis	P00189	Fzd	BOVIN|Ensembl=ENSBTAG00000035084|UniProtKB=F1MLG5	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF22	FRIZZLED-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=94925|UniProtKB=P30728	D(3) dopamine receptor	IDA	11248120	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P02746	Heme biosynthesis	P02979	porphobilinogen synthase	CANLF|Ensembl=ENSCAFG00000003246|UniProtKB=F1PZA0	Delta-aminolevulinic acid dehydratase	ISS			PTHR11458:SF0	DELTA-AMINOLEVULINIC ACID DEHYDRATASE
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CAEBR|Gene=CBG02401|UniProtKB=A8WUE7	Protein CBR-NMR-1	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00007	Axon guidance mediated by semaphorins	P00341	Rho	MONDO|Ensembl=ENSMODG00000012981|UniProtKB=F7CS91	Uncharacterized protein	ISS	10556059	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	PANTR|Ensembl=ENSPTRG00000010250|UniProtKB=H2QEX8	Uncharacterized protein	ISS	9783586	PubMed	PTHR10814:SF2	TRANSDUCIN-LIKE ENHANCER PROTEIN 6
P04393	Ras Pathway	P04559	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12874273	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00047	PDGF signaling pathway	P01153	GSK3	RAT|RGD=620351|UniProtKB=P18265	Glycogen synthase kinase-3 alpha	ISS	2164470	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MOUSE|MGI=MGI=95821|UniProtKB=Q01097	Glutamate receptor ionotropic, NMDA 2B	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00048	PI3 kinase pathway	P01188	Gbetagamma	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00010	B cell activation	P00371	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	PANTR|Ensembl=ENSPTRG00000018684|UniProtKB=C7G3M7	Glutamate receptor, metabotropic 1	ISS	9407094	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00047	PDGF signaling pathway	P01162	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=88397|UniProtKB=Q9ERZ4	Muscarinic acetylcholine receptor M2	IDA	11166329	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P02770	Pyridoxal phosphate salvage pathway	P03121	Pyridoxal kinase	ANOGA|EnsemblGenome=AGAP005929|UniProtKB=Q7Q6C1	AGAP005929-PA	ISS			PTHR10534:SF2	PYRIDOXAL KINASE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00057	Wnt signaling pathway	P01429	Axin	MOUSE|MGI=MGI=1270862|UniProtKB=O88566	Axin-2	IDA	9554852	PubMed	PTHR10845:SF103	AXIN-2
P00005	Angiogenesis	P00194	Paxillin	PANTR|Ensembl=ENSPTRG00000005527|UniProtKB=H2Q704	Paxillin	ISS	9182576	PubMed	PTHR24216:SF11	PAXILLIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00047	PDGF signaling pathway	P01140	ELK	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	10487205	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	MONDO|Ensembl=ENSMODG00000011791|UniProtKB=F7CBU9	Phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00049	Parkinson disease	P01238	14-3-3	BOVIN|Ensembl=ENSBTAG00000002108|UniProtKB=Q3SZI4	14-3-3 protein theta	ISS	10407019	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00561	STAT	MONDO|Ensembl=ENSMODG00000014836|UniProtKB=F7D2D3	Signal transducer and activator of transcription	ISS	10835485	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DANRE|ZFIN=ZDB-GENE-041001-104|UniProtKB=Q5TZD4	Protein kinase C	ISS	11880265	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	RAT|RGD=1305236|UniProtKB=B0BN93	26S proteasome non-ATPase regulatory subunit 13	ISS	10225435	PubMed	PTHR10539:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	HUMAN|HGNC=129|UniProtKB=P68133	Actin, alpha skeletal muscle	IC	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00029	Huntington disease	P00805	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04397	p53 pathway by glucose deprivation	P04641	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05957	K+ channel	MACMU|Ensembl=ENSMMUG00000005826|UniProtKB=F6VE51	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-030131-7595|UniProtKB=Q6PBR4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	HUMAN|HGNC=4043|UniProtKB=Q13467	Frizzled-5	TAS	8717036	PubMed	PTHR11309:SF126	FRIZZLED-5
P00036	Interleukin signaling pathway	P00993	p21CIP1	RAT|RGD=69328|UniProtKB=Q64315	Cyclin-dependent kinase inhibitor 1A	ISS	7774811	PubMed	PTHR10265:SF16	CYCLIN-DEPENDENT KINASE INHIBITOR 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00545	JNK1-3	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02734	Chorismate biosynthesis	P02872	3-Dehydroquinate synthase	NEUCR|EnsemblGenome=EFNCRG00000001777|UniProtKB=Q8X071	Pentafunctional AROM polypeptide	ISS			PTHR21090:SF5	PENTAFUNCTIONAL AROM POLYPEPTIDE
P00029	Huntington disease	P00807	Actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00019	Endothelin signaling pathway	P00570	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	176910	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000002775|UniProtKB=H2RB55	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00060	Ubiquitin proteasome pathway	P01491	E2	BOVIN|Ensembl=ENSBTAG00000021767|UniProtKB=Q0P5K3	Ubiquitin-conjugating enzyme E2 N	ISS			PTHR43902:SF2	UBIQUITIN-CONJUGATING ENZYME E2 N
P00055	Transcription regulation by bZIP transcription factor	P01398	TFIIEalpha	PANTR|Ensembl=ENSPTRG00000015273|UniProtKB=H2QN66	General transcription factor IIE, polypeptide 1, alpha 56kDa	ISS	92065982	PubMed	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	NEUCR|EnsemblGenome=EFNCRG00000003957|UniProtKB=V5ILY7	Protein kinase gsk3	ISS	21361340	gi	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00021	FGF signaling pathway	P00644	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CAEEL|WormBase=WBGene00001679|UniProtKB=P17343	Guanine nucleotide-binding protein subunit beta-1	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00029	Huntington disease	P00790	beta-Tubulin	RAT|RGD=735101|UniProtKB=Q6P9T8	Tubulin beta-4B chain	ISS	12932731	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	RAT|RGD=628852|UniProtKB=Q02294	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	8386525	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04393	Ras Pathway	P04546	GSK3	MOUSE|MGI=MGI=2152453|UniProtKB=Q2NL51	Glycogen synthase kinase-3 alpha	ISS	12086949	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00018	EGF receptor signaling pathway	P00555	MKK4,7	BOVIN|Ensembl=ENSBTAG00000012103|UniProtKB=A5PJP8	MAP2K4 protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00018	EGF receptor signaling pathway	P00564	Rac	ENTHI|EnsemblGenome=EHI_181250|UniProtKB=C4M5Z7	Rho family GTPase	IGI	8649368	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00010	B cell activation	P00391	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00547	PP2A	MOUSE|MGI=MGI=1349473|UniProtKB=Q61151	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	ISS	8703017	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00010	B cell activation	P00371	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00787	MAPKK4	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00012	Cadherin signaling pathway	P00474	Wnt	MACMU|Ensembl=ENSMMUG00000006915|UniProtKB=F7EZ32	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00037	Ionotropic glutamate receptor pathway	P01021	Vglut	MACMU|Ensembl=ENSMMUG00000020368|UniProtKB=F6UMW2	Uncharacterized protein	ISS	12815758	PubMed	PTHR11662:SF201	VESICULAR GLUTAMATE TRANSPORTER 2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01438	PP2A	SCHPO|PomBase=SPCC188.02|UniProtKB=Q10428	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta 1 isoform	ISS	10092233	PubMed	PTHR10257:SF3	PP2A-B', ISOFORM B
P00006	Apoptosis signaling pathway	P00269	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00623	FGF	MONDO|Ensembl=ENSMODG00000006480|UniProtKB=F7F2X9	Fibroblast growth factor	ISS	12738892	PubMed	PTHR11486:SF4	FIBROBLAST GROWTH FACTOR 18
P00056	VEGF signaling pathway	P01412	HSP27	MONDO|Ensembl=ENSMODG00000014448|UniProtKB=F7ATU3	Uncharacterized protein	ISS			PTHR11527:SF163	HEAT SHOCK PROTEIN BETA-2
P00047	PDGF signaling pathway	P01142	p90RSK	HUMAN|HGNC=10432|UniProtKB=P51812	Ribosomal protein S6 kinase alpha-3	ISS	10480933	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01173	STAT	HUMAN|HGNC=11364|UniProtKB=P40763	Signal transducer and activator of transcription 3	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF31	SUBFAMILY NOT NAMED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04393	Ras Pathway	P04541	p90RSK	MACMU|Ensembl=ENSMMUG00000022111|UniProtKB=F7H7W3	Ribosomal protein S6 kinase	ISS	15226426	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00018	EGF receptor signaling pathway	P00562	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04396	Vitamin D metabolism and pathway	P04602	RXR	HUMAN|HGNC=10477|UniProtKB=P19793	Retinoic acid receptor RXR-alpha	RCA			PTHR24083:SF39	RETINOIC ACID RECEPTOR RXR-ALPHA
P00018	EGF receptor signaling pathway	P00547	PP2A	ORNAN|Ensembl=ENSOANG00000008492|UniProtKB=F6XL57	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=12782|UniProtKB=P56703	Proto-oncogene Wnt-3	IDA	8717036	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P00034	Integrin signalling pathway	P00925	MEK	MACMU|Ensembl=ENSMMUG00000010904|UniProtKB=F7GLY5	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00115	Nicastrin	MOUSE|MGI=MGI=1891700|UniProtKB=P57716	Nicastrin	IDA	10993067	PubMed	PTHR21092:SF0	NICASTRIN
P00022	General transcription by RNA polymerase I	P00657	TBP	CAEEL|WormBase=WBGene00006542|UniProtKB=P32085	TATA-box-binding protein	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	PANTR|Ensembl=ENSPTRG00000002706|UniProtKB=H2Q272	Receptor protein serine/threonine kinase	ISS	10683140	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	DANRE|ZFIN=ZDB-GENE-040718-134|UniProtKB=Q6DH55	Guanine nucleotide binding protein (G protein), beta polypeptide 3, like	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	ORNAN|Ensembl=ENSOANG00000000493|UniProtKB=F7EPA8	Uncharacterized protein	ISS	11701344	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00023	General transcription regulation	P00668	TFIIB	XENTR|Xenbase=XB-GENE-946065|UniProtKB=F7BB98	Uncharacterized protein	ISS	180660	OMIM	PTHR11618:SF4	TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	FUSNN|EnsemblGenome=FN0240|UniProtKB=Q8RGP6	Thymidylate synthase	ISS			PTHR11548:SF1	SUBFAMILY NOT NAMED
P02777	Succinate to proprionate conversion	P03161	Methylmalonyl-CoA mutase	RAT|RGD=1587662|UniProtKB=D3ZKG1	Protein Mut	ISS			PTHR42710:SF1	METHYLMALONYL-COA MUTASE, MITOCHONDRIAL
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00632	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	IC	15313841	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	RCA	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00551	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IGI	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	IDA	10514528	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	RAT|RGD=67385|UniProtKB=Q8VGC3	Voltage-dependent L-type calcium channel subunit beta-2	ISS	20088160	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IGI	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00029	Huntington disease	P00780	Microtubule	ORYSJ|EnsemblGenome=OS01G0805900|UniProtKB=P45960	Tubulin beta-4 chain	IDA	12932731	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00023	General transcription regulation	P00658	TBP-associated factors	HUMAN|HGNC=17300|UniProtKB=Q7Z7C8	Transcription initiation factor TFIID subunit 8	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P06664	Gonadotropin-releasing hormone receptor pathway	P06786	ERK1/2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	RCA	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00045	Notch signaling pathway	P01104	Serrate	BOVIN|Ensembl=ENSBTAG00000012817|UniProtKB=E1BDN7	Delta-like protein	ISS	8955070	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000008710|UniProtKB=F7E1W0	Uncharacterized protein	ISS	8120095	PubMed	PTHR43912:SF3	PROTOCADHERIN-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	HUMAN|HGNC=1967|UniProtKB=P07510	Acetylcholine receptor subunit gamma	IC	95224005	PubMed	PTHR18945:SF60	ACETYLCHOLINE RECEPTOR SUBUNIT GAMMA
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	STRCO|Gene=CAD30959|UniProtKB=Q9ADJ9	Putative deaminase	ISS			PTHR44192:SF2	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00920	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MOUSE|MGI=MGI=87902|UniProtKB=P68134	Actin, alpha skeletal muscle	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	ARATH|TAIR=AT1G55970|UniProtKB=Q9LG11	Histone acetyltransferase HAC4	TAS	8413673	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_125401|UniProtKB=C3ZTX6	Putative uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CHICK|Gene=MYO5A|UniProtKB=Q02440	Unconventional myosin-Va	IC			PTHR13140:SF273	UNCONVENTIONAL MYOSIN-VA
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	DROME|FlyBase=FBgn0003716|UniProtKB=Q9VMT1	Receptor protein serine/threonine kinase	TAS	9395284	PubMed	PTHR23255:SF68	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	RCA	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01369	MKK1	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00053	T cell activation	P01332	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g210933|UniProtKB=A7SEA7	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	P01465	Ggamma	BOVIN|Ensembl=ENSBTAG00000035697|UniProtKB=Q28024	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IDA	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00017	DNA replication	P00527	Histones	ANOGA|EnsemblGenome=AGAP001813|UniProtKB=Q7PUQ8	Histone H3	ISS	20448842	PubMed	PTHR11426:SF179	HISTONE H3.3
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00034	Integrin signalling pathway	P00951	Jnk	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-977853|UniProtKB=F7EBE7	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	HUMAN|HGNC=4596|UniProtKB=Q14833	Metabotropic glutamate receptor 4	IDA			PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00048	PI3 kinase pathway	P01185	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00021	FGF signaling pathway	P00628	JNK1-3	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01407	Erk	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05963	MAO	BOVIN|Gene=MAOB|UniProtKB=P56560	Amine oxidase [flavin-containing] B	ISS	90344230	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P04392	P53 pathway feedback loops 1	G04685	p73DeltaN	MACMU|Ensembl=ENSMMUG00000016466|UniProtKB=F7GBH1	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	NAS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00778	NMDA receptor	DANRE|ZFIN=ZDB-GENE-051202-2|UniProtKB=Q6ZM67	Uncharacterized protein	ISS	92049750	PubMed	PTHR44391:SF3	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00221	JNK1	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	ISS	10207617	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00029	Huntington disease	P00777	CBP	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	TAS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	ORYSJ|EnsemblGenome=OS06G0671900|UniProtKB=Q40665	Tubulin beta-3 chain	ISS	12932731	PubMed	PTHR11588:SF245	TUBULIN BETA-4 CHAIN-RELATED
P00059	p53 pathway	P04609	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CAEBR|Gene=CBG23090|UniProtKB=A8Y4R0	Protein CBG23090	ISS	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS			PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	G01511	SPRY	MOUSE|MGI=MGI=1345138|UniProtKB=Q9QXV8	Protein sprouty homolog 2	IGI	12225946	PubMed	PTHR12365:SF8	PROTEIN SPROUTY HOMOLOG 2
P00010	B cell activation	P00383	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9060|UniProtKB=P51178	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	12860966	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00029	Huntington disease	P00807	Actin	MOUSE|MGI=MGI=87905|UniProtKB=P68033	Actin, alpha cardiac muscle 1	IDA	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	CANLF|Gene=PSEN1|UniProtKB=Q6RH31	Presenilin-1	ISS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00010	B cell activation	P00383	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00508	Cofilin	PANTR|Ensembl=ENSPTRG00000006254|UniProtKB=H2Q860	Cofilin 2 (Muscle)	ISS			PTHR11913:SF15	COFILIN-2
P00053	T cell activation	P01337	B7	PANTR|Ensembl=ENSPTRG00000015288|UniProtKB=H2QN76	Uncharacterized protein	ISS	7694363	PubMed	PTHR25466:SF2	T-LYMPHOCYTE ACTIVATION ANTIGEN CD86
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MACMU|Ensembl=ENSMMUG00000000289|UniProtKB=F7A9T0	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00006	Apoptosis signaling pathway	P00321	HSP70	ARATH|TAIR=AT1G09080|UniProtKB=Q8H1B3	Probable mediator of RNA polymerase II transcription subunit 37b	ISS	12150907	PubMed	PTHR19375:SF215	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 37B-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IDA	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	MOUSE|MGI=MGI=88296|UniProtKB=O55017	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	15079861	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00015	Circadian clock system	G01497	cry	PANTR|Ensembl=ENSPTRG00000003537|UniProtKB=H2Q3H0	Uncharacterized protein	ISS	11804325	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P04397	p53 pathway by glucose deprivation	P04641	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00249	PAK	BOVIN|Ensembl=ENSBTAG00000010191|UniProtKB=Q08E52	Serine/threonine-protein kinase PAK 1	ISS	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00018	EGF receptor signaling pathway	P00562	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04398	p53 pathway feedback loops 2	P04665	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P06214	GBB signaling pathway	P06299	MED	DROME|FlyBase=FBgn0011655|UniProtKB=O62609	Mothers against decapentaplegic homolog	IEA	9395284	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00018	EGF receptor signaling pathway	P00565	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IGI	3755548	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00004	Alzheimer disease-presenilin pathway	P00114	actin	TRIVA|Gene=TVAG_337240|UniProtKB=P90623	Actin	IDA			PTHR11937:SF155	ACTIN-5C-RELATED
P02738	De novo purine biosynthesis	P02899	GMP synthase	PANTR|Ensembl=ENSPTRG00000015555|UniProtKB=H2QNM5	Guanine monphosphate synthetase	ISS			PTHR11922:SF2	GMP SYNTHASE  GLUTAMINE-HYDROLYZING
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00019	Endothelin signaling pathway	P00587	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00987	SRF	CANLF|Ensembl=ENSCAFG00000001829|UniProtKB=F1PH12	Uncharacterized protein	ISS	8660892	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	TAS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00057	Wnt signaling pathway	P01443	Phospholipase C	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05916	Opioid prodynorphin pathway	P06002	G-protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	BOVIN|Ensembl=ENSBTAG00000010740|UniProtKB=P04975	Clathrin light chain B	ISS	9388255	PubMed	PTHR10639:SF2	CLATHRIN LIGHT CHAIN B
P00018	EGF receptor signaling pathway	G01511	SPRY	HUMAN|HGNC=15533|UniProtKB=Q9C004	Protein sprouty homolog 4	ISS	10330503	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000022550|UniProtKB=F6Y9I6	Serine/threonine-protein kinase	ISS	12393506	PubMed	PTHR22968:SF9	SERINE/THREONINE-PROTEIN KINASE D1
P00005	Angiogenesis	P00186	FGFR-1	CANLF|Ensembl=ENSCAFG00000005970|UniProtKB=E2R186	Fibroblast growth factor receptor	ISS	9989949	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00949	Shc	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	IPI	8264585	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00056	VEGF signaling pathway	P01425	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00012	Cadherin signaling pathway	P00470	F-actin	BOVIN|Gene=ACTG2|UniProtKB=Q5E9B5	Actin, gamma-enteric smooth muscle	ISS	3487386	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00021	FGF signaling pathway	P00633	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P05915	Opioid proenkephalin pathway	P05990	K+ channel	CHICK|Ensembl=ENSGALG00000016193|UniProtKB=E1BYI0	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00057	Wnt signaling pathway	P01457	GBeta	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00552	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MONDO|Ensembl=ENSMODG00000001430|UniProtKB=F7BCI5	Uncharacterized protein	ISS	8163524	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04393	Ras Pathway	P04552	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04397	p53 pathway by glucose deprivation	P04641	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	MOUSE|MGI=MGI=1278315|UniProtKB=Q91VN0	Low-density lipoprotein receptor-related protein 5	ISS	11029006	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P05918	p38 MAPK pathway	P06020	p38delta	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00012	Cadherin signaling pathway	P00470	F-actin	CAEEL|WormBase=WBGene00000064|UniProtKB=P10984	Actin-2	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	PSEAE|EnsemblGenome=PA5549|UniProtKB=Q9HT25	Glutamine--fructose-6-phosphate aminotransferase [isomerizing]	ISS			PTHR10937:SF0	GH12731P-RELATED
P02759	Pyridoxal-5-phosphate biosynthesis	P03058	Phosphohydroxythreonine aminotransferase	HUMAN|HGNC=19129|UniProtKB=Q9Y617	Phosphoserine aminotransferase	ISS	20886743	gi	PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00048	PI3 kinase pathway	P01177	P110ACT	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02771	Pyrimidine Metabolism	P03129	Aminotransferase	BOVIN|Gene=ABAT|UniProtKB=Q9BGI0	4-aminobutyrate aminotransferase, mitochondrial	ISS	2496985	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00030	Hypoxia response via HIF activation	P00819	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00570	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	BOVIN|Gene=MMP2|UniProtKB=Q9GLE5	72 kDa type IV collagenase	TAS	12834808	PubMed	PTHR10201:SF29	72 KDA TYPE IV COLLAGENASE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00019	Endothelin signaling pathway	P00589	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	BOVIN|Ensembl=ENSBTAG00000018576|UniProtKB=A8E641	DPYSL5 protein	ISS	10851247	PubMed	PTHR11647:SF58	DIHYDROPYRIMIDINASE-RELATED PROTEIN 5
P00053	T cell activation	P01316	MHC-antigen	MOUSE|MGI=MGI=95922|UniProtKB=P35737	Class II histocompatibility antigen, M beta 1 chain	IPI	3112582	PubMed	PTHR19944:SF65	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DM BETA CHAIN
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	IC	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00054	Toll receptor signaling pathway	P01375	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00053	T cell activation	P01332	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IDA	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	9754712	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	HUMAN|HGNC=7881|UniProtKB=P46531	Neurogenic locus notch homolog protein 1	IDA	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DICDI|dictyBase=DDB_G0283907|UniProtKB=P34099	cAMP-dependent protein kinase catalytic subunit	IC	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00018	EGF receptor signaling pathway	P00552	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	DROME|FlyBase=FBgn0010399|UniProtKB=Q24418	Glutamate [NMDA] receptor subunit 1	IC	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04393	Ras Pathway	P04546	GSK3	RAT|RGD=620351|UniProtKB=P18265	Glycogen synthase kinase-3 alpha	IDA	11995474	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00047	PDGF signaling pathway	P01163	c-Jun	XENTR|Xenbase=XB-GENE-482228|UniProtKB=F6RYL1	Uncharacterized protein	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MACMU|Ensembl=ENSMMUG00000009341|UniProtKB=F6UA54	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01284	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P06959	CCKR signaling map	P07154	HSP27	HUMAN|HGNC=5246|UniProtKB=P04792	Heat shock protein beta-1	RCA	9727040	PubMed	PTHR11527:SF114	HEAT SHOCK PROTEIN BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000003043|UniProtKB=P63212	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	XENTR|Xenbase=XB-GENE-5755296|UniProtKB=F7ELS1	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF76	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=109355|UniProtKB=O35526	Syntaxin-1A	ISS	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00021	FGF signaling pathway	P00644	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05731	GABA-B receptor II signaling	P05755	Gbeta	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00034	Integrin signalling pathway	P00907	ERK	MONDO|Ensembl=ENSMODG00000001962|UniProtKB=F6V2H6	Uncharacterized protein	ISS	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00011	Blood coagulation	P00421	alpha1-antitrypsin	BOVIN|Ensembl=ENSBTAG00000018843|UniProtKB=P34955	Alpha-1-antiproteinase	ISS	461442	gi	PTHR11461:SF165	ALPHA-1-ANTITRYPSIN-RELATED
P00007	Axon guidance mediated by semaphorins	P00339	CRMP	BOVIN|Ensembl=ENSBTAG00000018373|UniProtKB=O02675	Dihydropyrimidinase-related protein 2	ISS	7637782	PubMed	PTHR11647:SF56	DIHYDROPYRIMIDINASE-RELATED PROTEIN 2
P06959	CCKR signaling map	P07215	G17	HUMAN|HGNC=4164|UniProtKB=P01350	Gastrin	RCA	11181951	PubMed	PTHR19309:SF0	GASTRIN
P00037	Ionotropic glutamate receptor pathway	P01026	KA	CHICK|Ensembl=ENSGALG00000002098|UniProtKB=F1P0L4	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04393	Ras Pathway	P04541	p90RSK	RAT|RGD=620676|UniProtKB=F1M7N7	Ribosomal protein S6 kinase	ISS	1922062	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00019	Endothelin signaling pathway	P00586	Gq	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04393	Ras Pathway	P04552	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TRIAD|EnsemblGenome=TriadG35956|UniProtKB=Q7YTV5	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00029	Huntington disease	P00796	Kainate receptor	MACMU|Ensembl=ENSMMUG00000009679|UniProtKB=F6YBQ8	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00005	Angiogenesis	P00189	Fzd	ANOGA|Gene=AgaP_AGAP011382|UniProtKB=Q7Q2X0	AGAP011382-PA (Fragment)	ISS			PTHR11309:SF47	FRIZZLED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2344|UniProtKB=P08485	Muscarinic acetylcholine receptor M4	IDA	12181435	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00057	Wnt signaling pathway	P01431	LRP5/6	RAT|RGD=1304749|UniProtKB=A0A0G2K0H3	Protein Lrp6	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00004	Alzheimer disease-presenilin pathway	P00165	E-cadherin N-terminal fragment	RAT|RGD=69279|UniProtKB=Q9R0T4	Cadherin-1	TAS	8120095	PubMed	PTHR24027:SF319	CADHERIN-1
P00034	Integrin signalling pathway	P00916	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000007882|UniProtKB=G3X7Z2	Uncharacterized protein	ISS	14507926	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00012	Cadherin signaling pathway	P00475	Frizzled	BOVIN|Ensembl=ENSBTAG00000035084|UniProtKB=F1MLG5	Uncharacterized protein	ISS	12549854	PubMed	PTHR11309:SF22	FRIZZLED-3
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	10218114	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=98961|UniProtKB=P24383	Protein Wnt-7a	IDA	11266476	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00034	Integrin signalling pathway	P00936	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06773	gnai/o	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05913	Enkephalin release	P05974	G-Protein (i)	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00644	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=12781|UniProtKB=Q93097	Protein Wnt-2b	IDA	12549854	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	TAKRU|Ensembl=ENSTRUG00000017142|UniProtKB=H2V3Y5	Fructose-bisphosphate aldolase (Fragment)	ISS	2828145	gi	PTHR11627:SF3	FRUCTOSE-BISPHOSPHATE ALDOLASE C
P00021	FGF signaling pathway	P00629	PP2A	HUMAN|HGNC=9300|UniProtKB=P62714	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	IDA	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	SCHMA|EnsemblGenome=Smp_079960|UniProtKB=G4VTA4	Putative tubulin beta chain	ISS	12932731	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00010	B cell activation	P00391	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04397	p53 pathway by glucose deprivation	P04641	Akt	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	12655147	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CANLF|Ensembl=ENSCAFG00000005662|UniProtKB=E2R907	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	PANTR|Ensembl=ENSPTRG00000009085|UniProtKB=H2RDQ2	Uncharacterized protein	ISS	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00054	Toll receptor signaling pathway	P01375	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00562	p38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IGI	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00018	EGF receptor signaling pathway	P00551	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IDA	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00383	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00009	Axon guidance mediated by netrin	P00366	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	10540223	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00004	Alzheimer disease-presenilin pathway	P00126	Fe65	HUMAN|HGNC=582|UniProtKB=Q92870	Amyloid beta A4 precursor protein-binding family B member 2	IDA			PTHR14058:SF11	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 2
P00021	FGF signaling pathway	P00632	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00591	PLCbeta	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00006	Apoptosis signaling pathway	P00269	MAPK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00005	Angiogenesis	P00186	FGFR-1	ORNAN|Ensembl=ENSOANG00000003252|UniProtKB=F6SM70	Fibroblast growth factor receptor	ISS	9989949	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P00053	T cell activation	P01318	PKC-theta	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PHYPA|Gene=PHYPADRAFT_172686|UniProtKB=A9TYG6	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IDA	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	CHICK|Ensembl=ENSGALG00000005065|UniProtKB=P49147	Cytosolic phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00018	EGF receptor signaling pathway	P00546	GAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	IGI	2574500	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00046	Oxidative stress response	P01131	MKP5	RAT|RGD=620897|UniProtKB=Q64623	Dual specificity protein phosphatase 1	TAS			PTHR10159:SF309	DUAL SPECIFICITY PROTEIN PHOSPHATASE 1
P00012	Cadherin signaling pathway	P00470	F-actin	ANOGA|EnsemblGenome=AGAP001676|UniProtKB=Q7PXZ8	AGAP001676-PA	IC	10974003	PubMed	PTHR11937:SF368	ACTIN, INDIRECT FLIGHT MUSCLE
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IGI	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00018	EGF receptor signaling pathway	P00549	EGF	PANTR|Ensembl=ENSPTRG00000017311|UniProtKB=H2QRM1	Heparin-binding EGF-like growth factor	ISS	1346256	gi	PTHR10740:SF4	PROHEPARIN-BINDING EGF-LIKE GROWTH FACTOR
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04393	Ras Pathway	P04557	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	BOVIN|Ensembl=ENSBTAG00000001067|UniProtKB=E1BAB4	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00013	Cell cycle	P00480	Proteasome	BOVIN|Ensembl=ENSBTAG00000002423|UniProtKB=Q2KJ25	26S proteasome non-ATPase regulatory subunit 12	ISS	9426256	PubMed	PTHR10855:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	SCHMA|EnsemblGenome=Smp_059340|UniProtKB=C4QDC7	Guanine nucleotide-binding protein G(S) subunit alpha (Adenylate cyclase-stimulating G alpha protein),putative	ISS			PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00003	Alzheimer disease-amyloid secretase pathway	P00079	alpha7 nicotinic acetylcholine receptor	CHICK|Gene=CHRNA7|UniProtKB=P22770	Neuronal acetylcholine receptor subunit alpha-7	IDA	85270494	PubMed	PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CHICK|Ensembl=ENSGALG00000009405|UniProtKB=F1NKF1	Uncharacterized protein	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	XENTR|Xenbase=XB-GENE-992519|UniProtKB=F6VS22	Uncharacterized protein	ISS			PTHR43893:SF8	D 1B  DOPAMINE RECEPTOR
P05918	p38 MAPK pathway	P05922	MKP1	RAT|RGD=620897|UniProtKB=Q64623	Dual specificity protein phosphatase 1	RCA			PTHR10159:SF309	DUAL SPECIFICITY PROTEIN PHOSPHATASE 1
P00049	Parkinson disease	P01211	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	10755300	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00859	NFkappaB	MOUSE|MGI=MGI=1099800|UniProtKB=Q9WTK5	Nuclear factor NF-kappa-B p100 subunit	IDA	20151924	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00551	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04651	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	HUMAN|HGNC=7881|UniProtKB=P46531	Neurogenic locus notch homolog protein 1	IDA	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00018	EGF receptor signaling pathway	P00541	Spry	HUMAN|HGNC=11271|UniProtKB=O43610	Protein sprouty homolog 3	ISS			PTHR12365:SF9	PROTEIN SPROUTY HOMOLOG 3
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	BOVIN|Ensembl=ENSBTAG00000047202|UniProtKB=G3N3K3	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00057	Wnt signaling pathway	P01428	Frizzled	BOVIN|Ensembl=ENSBTAG00000020957|UniProtKB=F1MGM1	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF126	FRIZZLED-5
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CHICK|Ensembl=ENSGALG00000027629|UniProtKB=Q5ZJ03	Guanine nucleotide-binding protein subunit gamma	IC	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CANAL|CGD=CAL0064759|UniProtKB=Q5AKX0	Uncharacterized protein	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	DROME|FlyBase=FBgn0002413|UniProtKB=O76324	Discs overgrown protein kinase	IDA	11955435	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	HUMAN|HGNC=10620|UniProtKB=O00585	C-C motif chemokine 21	IDA	11801633	PubMed	PTHR12015:SF72	C-C MOTIF CHEMOKINE 21
P00048	PI3 kinase pathway	P01179	PKB	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	IDA	10514528	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00057	Wnt signaling pathway	P01444	Wnt	TAKRU|Ensembl=ENSTRUG00000011280|UniProtKB=H2TUW3	Protein Wnt	IDA	11266476	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	RAT|RGD=3694|UniProtKB=Q01827	Synaptic vesicular amine transporter	ISS	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00003	Alzheimer disease-amyloid secretase pathway	P00091	Aph-1	DROME|FlyBase=FBgn0031458|UniProtKB=Q9VQG2	Gamma-secretase subunit Aph-1	IDA	12110170	PubMed	PTHR12889:SF0	GAMMA-SECRETASE SUBUNIT APH-1
P04393	Ras Pathway	P04574	PLD	ARATH|TAIR=AT4G11850|UniProtKB=Q9T053	Phospholipase D gamma 1	ISS			PTHR18896:SF65	PHOSPHOLIPASE D BETA 1-RELATED
P00021	FGF signaling pathway	P00632	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00012	Cadherin signaling pathway	P00474	Wnt	PANTR|Ensembl=ENSPTRG00000004893|UniProtKB=H2Q5U4	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	XENTR|Xenbase=XB-GENE-480347|UniProtKB=Q6P640	Actin, alpha cardiac muscle 1	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P02765	Phenylalanine biosynthesis	P03099	Prephenate dehydratase	AQUAE|EnsemblGenome=aq_951|UniProtKB=O67085	P-protein	ISS			PTHR21022:SF0	PREPHENATE DEHYDRATASE-RELATED
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=3972|UniProtKB=Q12841	Follistatin-related protein 1	ISS	8717036	PubMed	PTHR10913:SF13	FOLLISTATIN-RELATED PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P06959	CCKR signaling map	G06984	ITGB1	HUMAN|HGNC=6153|UniProtKB=P05556	Integrin beta-1	RCA	16547500	PubMed	PTHR10082:SF28	INTEGRIN BETA-1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	ARATH|TAIR=AT4G09320|UniProtKB=P39207	Nucleoside diphosphate kinase 1	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	MACMU|Ensembl=ENSMMUG00000016675|UniProtKB=F6VTB5	Uncharacterized protein	ISS	11554554	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00005	Angiogenesis	P00221	JNK1	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P06587	Nicotine pharmacodynamics pathway	P06596	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8316835	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06832	c-Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	RCA	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00910	Grb2	MOUSE|MGI=MGI=1918770|UniProtKB=Q9CX99	GRB2-related adapter protein	ISS	8647802	PubMed	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01161	Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	RCA	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00029	Huntington disease	P00796	Kainate receptor	CANLF|Ensembl=ENSCAFG00000004930|UniProtKB=E2RFB5	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04393	Ras Pathway	P04548	ATF2	HUMAN|HGNC=784|UniProtKB=P15336	Cyclic AMP-dependent transcription factor ATF-2	ISS	15218628	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00021	FGF signaling pathway	P00629	PP2A	ANOGA|EnsemblGenome=AGAP003017|UniProtKB=Q7PR35	Serine/threonine-protein phosphatase	ISS			PTHR11668:SF24	SERINE/THREONINE-PROTEIN PHOSPHATASE 6 CATALYTIC SUBUNIT
P00020	FAS signaling pathway	P00615	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	RAT|RGD=2746|UniProtKB=P31424	Metabotropic glutamate receptor 5	ISS	12351712	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00049	Parkinson disease	P01230	Src kinase	DANRE|ZFIN=ZDB-GENE-030903-5|UniProtKB=Q6EWH2	Tyrosine-protein kinase fyna	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00057	Wnt signaling pathway	P01438	PP2A	ANOGA|EnsemblGenome=AGAP010172|UniProtKB=Q7PD38	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01151	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	TAS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02738	De novo purine biosynthesis	P02891	GDP kinase	CANLF|Ensembl=ENSCAFG00000015856|UniProtKB=J9P3S5	Nucleoside diphosphate kinase	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P00010	B cell activation	P00371	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	IC	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P02788	Xanthine and guanine salvage pathway	P03249	Guanine deaminase	MACMU|Ensembl=ENSMMUG00000019196|UniProtKB=F7CWS1	Guanine deaminase isoform b	ISS	11962625	PubMed	PTHR11271:SF6	GUANINE DEAMINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00056	VEGF signaling pathway	P01421	Rac	CAEBR|Gene=CBG02886|UniProtKB=A8WTA3	Protein CBR-RGA-1	ISS			PTHR23176:SF0	RHO GTPASE-ACTIVATING PROTEIN 68F
P00024	Glycolysis	P00675	Pyruvate kinase	ARATH|TAIR=AT5G52920|UniProtKB=Q9FLW9	Plastidial pyruvate kinase 2	ISS	15237303	gi	PTHR11817:SF2	PLASTIDIAL PYRUVATE KINASE 2
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00005	Angiogenesis	P00206	Wnt	RAT|RGD=69079|UniProtKB=M0R9D3	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00034	Integrin signalling pathway	P00951	Jnk	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	PANTR|Ensembl=ENSPTRG00000000323|UniProtKB=H2PYA3	Uncharacterized protein	ISS	12441358	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P02731	Biotin biosynthesis	P02858	8-Amino-7-oxononanoate synthase	BACSU|EnsemblGenome=BSU30220|UniProtKB=P53556	8-amino-7-oxononanoate synthase 2	ISS			PTHR13693:SF77	8-AMINO-7-OXONONANOATE SYNTHASE
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00057	Wnt signaling pathway	P01429	Axin	DANRE|ZFIN=ZDB-GENE-000403-2|UniProtKB=P57095	Axin-2	IDA	12356903	PubMed	PTHR10845:SF103	AXIN-2
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	TAKRU|Ensembl=ENSTRUG00000007253|UniProtKB=H2SZQ1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00057	Wnt signaling pathway	P01428	Frizzled	DROME|FlyBase=FBgn0016797|UniProtKB=Q9VVX3	Frizzled-2	IDA	8717036	PubMed	PTHR11309:SF90	FRIZZLED-8
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00046	Oxidative stress response	P01135	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	TAS	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=12788|UniProtKB=Q9H1J5	Protein Wnt-8a	IDA	8717036	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P00036	Interleukin signaling pathway	P00976	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00010	B cell activation	P00384	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00018	EGF receptor signaling pathway	P00558	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IGI	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	DROME|FlyBase=FBgn0046332|UniProtKB=P83101	Putative glycogen synthase kinase-3 homolog	TAS			PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000003236|UniProtKB=F7DNS6	Uncharacterized protein	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	CANLF|Ensembl=ENSCAFG00000013324|UniProtKB=F1PCS0	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00021	FGF signaling pathway	P00632	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IGI	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01407	Erk	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	DANRE|Ensembl=ENSDARG00000015050|UniProtKB=Q6PI52	Calmodulin	ISS	7514101	PubMed	PTHR23050:SF326	CALMODULIN
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00015	Circadian clock system	G01503	per	MOUSE|MGI=MGI=1098283|UniProtKB=O35973	Period circadian protein homolog 1	IDA	20570170	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00256	PLC-gamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00005	Angiogenesis	P00255	Notch	HUMAN|HGNC=7882|UniProtKB=Q04721	Neurogenic locus notch homolog protein 2	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00020	FAS signaling pathway	P00610	MKK4	MOUSE|MGI=MGI=1346869|UniProtKB=P47809	Dual specificity mitogen-activated protein kinase kinase 4	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00036	Interleukin signaling pathway	P00968	Ikk	BOVIN|Ensembl=ENSBTAG00000007591|UniProtKB=Q95KV1	Inhibitor of nuclear factor kappa-B kinase subunit alpha	ISS	12235208	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00053	T cell activation	P01312	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MONDO|Ensembl=ENSMODG00000008180|UniProtKB=F7E4E2	Uncharacterized protein (Fragment)	ISS	89264452	PubMed	PTHR13140:SF328	MYOSIN-10
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00648	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01177	P110ACT	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01306	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P05915	Opioid proenkephalin pathway	P05991	Enkephalin	BOVIN|Ensembl=ENSBTAG00000004924|UniProtKB=P01211	Proenkephalin-A	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05734	Synaptic vesicle trafficking	P05776	RIM1alpha/2alpha	MOUSE|MGI=MGI=2152972|UniProtKB=Q9EQZ7	Regulating synaptic membrane exocytosis protein 2	RCA			PTHR12157:SF15	REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN 2
P00047	PDGF signaling pathway	P01175	Shc	MOUSE|MGI=MGI=98296|UniProtKB=P98083	SHC-transforming protein 1	ISS	7798194	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	8787761	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00046	Oxidative stress response	P01134	cPLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	TAS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00019	Endothelin signaling pathway	P00586	Gq	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00005	Angiogenesis	P00203	Erk	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00016	Cytoskeletal regulation by Rho GTPase	P00508	Cofilin	ORNAN|Ensembl=ENSOANG00000014048|UniProtKB=F6PGG2	Uncharacterized protein (Fragment)	ISS			PTHR11913:SF15	COFILIN-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00054	Toll receptor signaling pathway	P01356	ERK2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05912	Dopamine receptor mediated signaling pathway	P05964	GNAZ	RAT|RGD=2717|UniProtKB=P19627	Guanine nucleotide-binding protein G(z) subunit alpha	RCA	16814816	PubMed	PTHR10218:SF65	GUANINE NUCLEOTIDE-BINDING PROTEIN G Z  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	PHYPA|Gene=PHYPADRAFT_183198|UniProtKB=A9SBU0	Predicted protein	ISS	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6856|UniProtKB=Q9Y6R4	Mitogen-activated protein kinase kinase kinase 4	ISS			PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00045	Notch signaling pathway	P01114	Ntm	CANLF|Ensembl=ENSCAFG00000019633|UniProtKB=F1PDC7	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=2685563|UniProtKB=Q80TF3	Protocadherin-19	ISS	8120095	PubMed	PTHR24028:SF40	PROTOCADHERIN-19
P05912	Dopamine receptor mediated signaling pathway	P05970	TH	CAEEL|WormBase=WBGene00000296|UniProtKB=P90986	Tyrosine 3-monooxygenase	ISS	12480184	PubMed	PTHR11473:SF15	TYROSINE 3-MONOOXYGENASE
P00034	Integrin signalling pathway	P00916	Ras	XENTR|Xenbase=XB-GENE-494548|UniProtKB=F7EC26	Uncharacterized protein	ISS	10825661	PubMed	PTHR24070:SF186	GTPASE KRAS
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	DROME|FlyBase=FBgn0010399|UniProtKB=Q24418	Glutamate [NMDA] receptor subunit 1	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00006	Apoptosis signaling pathway	P00272	ASK1	MOUSE|MGI=MGI=1346876|UniProtKB=O35099	Mitogen-activated protein kinase kinase kinase 5	ISS	12968034	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00053	T cell activation	P01300	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	TAS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00001	Adrenaline and noradrenaline biosynthesis	P00068	amine translocator	RAT|RGD=628664|UniProtKB=Q08469	Sodium-dependent neutral amino acid transporter B(0)AT2	IC	12719981	PubMed	PTHR11616:SF101	SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER B 0 AT2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	RAT|RGD=3571|UniProtKB=P49804	Regulator of G-protein signaling 8	IDA	8756726	PubMed	PTHR10845:SF147	REGULATOR OF G-PROTEIN SIGNALING 8
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00010	B cell activation	P00381	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00627	ERK1-2	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00010	B cell activation	P00380	fos	MACMU|Ensembl=ENSMMUG00000010574|UniProtKB=A5A6H2	C-fos	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P02747	Histidine biosynthesis	P02993	Phosphoribosylformimino-5-amino-1-phosphoribosyl-4 imadazol carboxamide isomerase	BACTN|EnsemblGenome=BT_1379|UniProtKB=Q8A7Z5	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase	ISS			PTHR43090:SF2	1- 5-PHOSPHORIBOSYL -5-  5-PHOSPHORIBOSYLAMINO METHYLIDENEAMINO  IMIDAZOLE-4-CARBOXAMIDE ISOMERASE
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00053	T cell activation	P01312	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00025	Hedgehog signaling pathway	P00692	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	MOUSE|MGI=MGI=1931148|UniProtKB=Q9WV84	Nucleoside diphosphate kinase, mitochondrial	ISS			PTHR11349:SF49	NUCLEOSIDE DIPHOSPHATE KINASE, MITOCHONDRIAL
P00056	VEGF signaling pathway	P01417	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01358	ERK1	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	MONDO|Ensembl=ENSMODG00000009988|UniProtKB=F6UST7	Uncharacterized protein	ISS	12374786	PubMed	PTHR11767:SF17	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 3
P00048	PI3 kinase pathway	P01202	p85	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	PHYIT|EnsemblGenome=PITG_06376|UniProtKB=D0N4Q3	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta, putative	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00035	Interferon-gamma signaling pathway	P00956	SOCS	RAT|RGD=1564914|UniProtKB=D3ZUE4	Protein Socs5	ISS	22247722	PubMed	PTHR44282:SF3	SUPPRESSOR OF CYTOKINE SIGNALING 5
P04395	Vasopressin synthesis	P04590	Vasopressin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	RCA	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00053	T cell activation	P01335	jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00019	Endothelin signaling pathway	P00578	eNOS	MOUSE|MGI=MGI=97362|UniProtKB=P70313	Nitric oxide synthase, endothelial	IGI	9837777	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=109356|UniProtKB=O09044	Synaptosomal-associated protein 23	IC	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P02743	Formyltetrahydroformate biosynthesis	P02953	Cobalamin dependent homocysteine transmethylase	BOVIN|Gene=MTR|UniProtKB=Q4JIJ3	Methionine synthase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00047	PDGF signaling pathway	P01142	p90RSK	BOVIN|Ensembl=ENSBTAG00000014447|UniProtKB=A4IFF4	Ribosomal protein S6 kinase	ISS	12213813	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00019	Endothelin signaling pathway	P00566	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	MACMU|Ensembl=ENSMMUG00000007605|UniProtKB=F6SJQ8	Uncharacterized protein	ISS	94365697	PubMed	PTHR11958:SF22	EXCITATORY AMINO ACID TRANSPORTER 5
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MACMU|Ensembl=ENSMMUG00000019112|UniProtKB=F6T8S6	N-methyl D-aspartate receptor subtype 2B	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00048	PI3 kinase pathway	P01194	S6K	MACMU|Ensembl=ENSMMUG00000005483|UniProtKB=F7G271	Uncharacterized protein	ISS	6755374	gi	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	XENTR|Xenbase=XB-GENE-969447|UniProtKB=Q0IIR4	Tubulin, beta 2C	ISS	12932731	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	PANTR|Ensembl=ENSPTRG00000004718|UniProtKB=H2Q5I0	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00059	p53 pathway	P04617	WRN	HUMAN|HGNC=12791|UniProtKB=Q14191	Werner syndrome ATP-dependent helicase	ISS			PTHR13710:SF120	WERNER SYNDROME ATP-DEPENDENT HELICASE
P00053	T cell activation	P01306	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00049	Parkinson disease	P01218	alpha-Synuclein	CHICK|Ensembl=ENSGALG00000010379|UniProtKB=Q9I9H1	Alpha-synuclein	TAS	9278044	PubMed	PTHR13820:SF5	ALPHA-SYNUCLEIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DICDI|dictyBase=DDB_G0283903|UniProtKB=Q54QB1	Extracellular signal-regulated kinase 2	TAS			PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00643	Raf-1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00269	MAPK	ORYSJ|EnsemblGenome=OS03G0285800|UniProtKB=Q10N20	Mitogen-activated protein kinase 5	ISS	10514528	PubMed	PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00013	Cell cycle	P00480	Proteasome	MOUSE|MGI=MGI=1916327|UniProtKB=Q8BG32	26S proteasome non-ATPase regulatory subunit 11	ISS	97227943	PubMed	PTHR10678:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	11554554	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000006342|UniProtKB=H2Q8A8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00019	Endothelin signaling pathway	P00581	Guanylate cyclase	CAEEL|WormBase=WBGene00020131|UniProtKB=Q86GV3	Receptor-type guanylate cyclase gcy-28	IC	97332697	PubMed	PTHR11920:SF296	RECEPTOR-TYPE GUANYLATE CYCLASE GCY-28
P00049	Parkinson disease	P01227	20S proteasome	CANLF|Ensembl=ENSCAFG00000016587|UniProtKB=E2QX17	Proteasome subunit beta type	ISS	12859888	PubMed	PTHR11599:SF62	PROTEASOME SUBUNIT BETA TYPE-3
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05734	Synaptic vesicle trafficking	P05773	Munc13	RAT|RGD=628592|UniProtKB=Q62770	Protein unc-13 homolog C	TAS	605836	OMIM	PTHR10480:SF2	PROTEIN UNC-13 HOMOLOG C
P00036	Interleukin signaling pathway	P00968	Ikk	HUMAN|HGNC=5960|UniProtKB=O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	IDA	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05913	Enkephalin release	P05977	G-Protein (s)	IXOSC|EnsemblGenome=ISCW009711|UniProtKB=B7Q3T6	THO complex subunit, putative	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	RCA	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00056	VEGF signaling pathway	P01405	VRAP	HUMAN|HGNC=10821|UniProtKB=Q9NP31	SH2 domain-containing protein 2A	IDA	Q9NP31	SPACC	PTHR14388:SF9	SH2 DOMAIN-CONTAINING PROTEIN 2A
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00034	Integrin signalling pathway	P00919	Arf6	ORNAN|Ensembl=ENSOANG00000013982|UniProtKB=F6URT1	Uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00034	Integrin signalling pathway	P00938	Cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P05916	Opioid prodynorphin pathway	P06002	G-protein	DICDI|dictyBase=DDB_G0277143|UniProtKB=P36408	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF31	SUBFAMILY NOT NAMED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	RCA	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CHICK|Ensembl=ENSGALG00000006540|UniProtKB=F1NW19	Uncharacterized protein	IDA			PTHR43893:SF13	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00797	p53	PANTR|Ensembl=ENSPTRG00000015733|UniProtKB=H2QNY5	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00057	Wnt signaling pathway	P01443	Phospholipase C	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00019	Endothelin signaling pathway	P00572	MEK	CAEBR|Gene=CBG04190|UniProtKB=A8WWD7	Protein CBR-MEK-2	ISS	17508425	gi	PTHR24361:SF629	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1
P00056	VEGF signaling pathway	P01415	MAPKAPK2/3	HUMAN|HGNC=6887|UniProtKB=P49137	MAP kinase-activated protein kinase 2	ISS	9628873	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	TAS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	XENTR|Xenbase=XB-GENE-491938|UniProtKB=Q6DIV8	Actin, alpha 1, skeletal muscle	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00007	Axon guidance mediated by semaphorins	P00330	CRAM	MOUSE|MGI=MGI=1929772|UniProtKB=Q9EQF6	Dihydropyrimidinase-related protein 5	ISS	11034345	PubMed	PTHR11647:SF58	DIHYDROPYRIMIDINASE-RELATED PROTEIN 5
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	HUMAN|HGNC=1389|UniProtKB=Q00975	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	14624853	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00034	Integrin signalling pathway	P00948	Rho	BOVIN|Ensembl=ENSBTAG00000004279|UniProtKB=P61585	Transforming protein RhoA	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00021	FGF signaling pathway	P00630	RKIP	ARATH|TAIR=AT2G27550|UniProtKB=Q9ZNV5	Protein CENTRORADIALIS-like	ISS			PTHR11362:SF48	PROTEIN CENTRORADIALIS-LIKE
P00034	Integrin signalling pathway	P00942	Fyn	CHICK|Gene=FYN|UniProtKB=Q05876	Tyrosine-protein kinase Fyn	IPI	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P06664	Gonadotropin-releasing hormone receptor pathway	P06841	gnaq/11	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	RCA	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05918	p38 MAPK pathway	P06026	MEKK4	CANLF|Ensembl=ENSCAFG00000000760|UniProtKB=E2R9L4	Uncharacterized protein	ISS	12052864	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00807	Actin	RAT|RGD=628837|UniProtKB=P60711	Actin, cytoplasmic 1	IDA	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00029	Huntington disease	P00807	Actin	CANLF|Ensembl=ENSCAFG00000015708|UniProtKB=F2Z4N0	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00057	Wnt signaling pathway	P01456	beta-arrestin	PANTR|Ensembl=ENSPTRG00000008601|UniProtKB=H2QBY1	Arrestin, beta 2	ISS	12464600	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	TAS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00545	JNK1-3	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00059	p53 pathway	P04630	PP2A	BOVIN|Ensembl=ENSBTAG00000009245|UniProtKB=Q0P594	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	DROME|FlyBase=FBgn0024920|UniProtKB=O76511	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00060	Ubiquitin proteasome pathway	P01491	E2	ORYSJ|EnsemblGenome=OS01G0273100|UniProtKB=Q9LIY1	Os01g0273100 protein	ISS			PTHR44189:SF1	UBIQUITIN-CONJUGATING ENZYME E2 C
P00018	EGF receptor signaling pathway	P00561	STAT	TAKRU|Ensembl=ENSTRUG00000011114|UniProtKB=H2TTP1	Signal transducer and activator of transcription	ISS			PTHR11801:SF19	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 4
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000023940|UniProtKB=F6RFW8	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00011	Blood coagulation	P00440	ATIII	BOVIN|Gene=SERPINC1|UniProtKB=P41361	Antithrombin-III	ISS	416622	gi	PTHR11461:SF53	ANTITHROMBIN-III
P04393	Ras Pathway	P04570	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00627	ERK1-2	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IDA	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00049	Parkinson disease	P01219	SAPK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P02788	Xanthine and guanine salvage pathway	P03245	Guanine phosphoribosyl transferase	HUMAN|HGNC=5157|UniProtKB=P00492	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF6	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02744	Fructose galactose metabolism	P02960	Galactokinase	MACMU|Ensembl=ENSMMUG00000009839|UniProtKB=F7G430	Uncharacterized protein	ISS			PTHR10457:SF7	N-ACETYLGALACTOSAMINE KINASE
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	HUMAN|HGNC=3084|UniProtKB=O14640	Segment polarity protein dishevelled homolog DVL-1	TAS	12549854	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00006	Apoptosis signaling pathway	P00260	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02772	Pyruvate metabolism	P03140	Pyruvate Carboxylase	MOUSE|MGI=MGI=97520|UniProtKB=Q05920	Pyruvate carboxylase, mitochondrial	ISS	12112657	PubMed	PTHR43778:SF2	PYRUVATE CARBOXYLASE, MITOCHONDRIAL
P00005	Angiogenesis	P00256	PLC-gamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MONDO|Ensembl=ENSMODG00000000771|UniProtKB=F6SSS3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00057	Wnt signaling pathway	P01451	Galpha	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00019	Endothelin signaling pathway	P00591	PLCbeta	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00518	Rho GEFs	MOUSE|MGI=MGI=1353510|UniProtKB=Q61210	Rho guanine nucleotide exchange factor 1	ISS	12024019	PubMed	PTHR12673:SF122	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P02756	N-acetylglucosamine metabolism	P03039	Glucosamine-1-phosphate acetyltransferase	LEPIN|EnsemblGenome=LA_3823|UniProtKB=Q8EZM9	UDP-N-acetylglucosamine diphosphorylase	ISS			PTHR43584:SF3	BIFUNCTIONAL PROTEIN GLMU
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00052	TGF-beta signaling pathway	P01284	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00010	B cell activation	P00391	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01188	Gbetagamma	DROME|FlyBase=FBgn0004623|UniProtKB=P29829	Guanine nucleotide-binding protein subunit beta-2	ISS	11313908	PubMed	PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00010	B cell activation	P00384	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	ISS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	TAS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MOUSE|MGI=MGI=1928896|UniProtKB=Q9R0Q6	Actin-related protein 2/3 complex subunit 1A	ISS	12932731	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00060	Ubiquitin proteasome pathway	P01491	E2	MONDO|Ensembl=ENSMODG00000013661|UniProtKB=F6TXY0	Uncharacterized protein	ISS			PTHR44189:SF1	UBIQUITIN-CONJUGATING ENZYME E2 C
P00005	Angiogenesis	P00181	SHP2	DANRE|ZFIN=ZDB-GENE-030131-5911|UniProtKB=F1QZU5	Tyrosine-protein phosphatase non-receptor type	ISS	14534538	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00004	Alzheimer disease-presenilin pathway	P00127	APP	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	RAT|RGD=70989|UniProtKB=Q78EA7	Bone morphogenetic protein receptor type-1A	TAS	9395284	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P02721	ATP synthesis	P02791	F1 alpha	HUMAN|HGNC=823|UniProtKB=P25705	ATP synthase subunit alpha, mitochondrial	ISS	11479684	PubMed	PTHR43089:SF4	ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL
P04393	Ras Pathway	P04559	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	15470041	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00053	T cell activation	P01322	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=2141917|UniProtKB=Q8BZ03	Serine/threonine-protein kinase D2	ISS	11062248	PubMed	PTHR22968:SF12	SERINE/THREONINE-PROTEIN KINASE D2
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	TAS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P05916	Opioid prodynorphin pathway	P06002	G-protein	DROME|FlyBase=FBgn0001122|UniProtKB=P16378	G protein alpha o subunit	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00951	Jnk	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	EMENI|EnsemblGenome=CADANIAG00002670|UniProtKB=Q5BH99	G-protein beta subunit [Source:UniProtKB/TrEMBLAcc:O74214]	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	RAT|RGD=2846|UniProtKB=P28564	5-hydroxytryptamine receptor 1B	ISS	12181435	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P00054	Toll receptor signaling pathway	P01357	MEKK1	MACMU|Ensembl=ENSMMUG00000012387|UniProtKB=F7EB20	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	RCA	1504106	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00060	Ubiquitin proteasome pathway	P01491	E2	IXOSC|EnsemblGenome=ISCW009979|UniProtKB=B7Q0U7	Ubiquitin protein ligase, putative	ISS			PTHR43898:SF1	UBIQUITIN-CONJUGATING ENZYME E2-17 KDA
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	G01545	scl-1	CAEEL|WormBase=WBGene00008625|UniProtKB=Q93444	SCP-Like extracellular protein	ISS			PTHR10334:SF171	SCP-LIKE EXTRACELLULAR PROTEIN
P00029	Huntington disease	P00774	Dynein complex	CHLRE|EnsemblGenome=CHLREDRAFT_60432|UniProtKB=A8JHU7	Flagellar inner arm dynein 1 heavy chain alpha	IPI	9454836	PubMed	PTHR10676:SF343	DYNEIN HEAVY CHAIN 10, AXONEMAL
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	RAT|RGD=621060|UniProtKB=O88777	Presenilin-2	TAS	9332390	PubMed	PTHR10202:SF13	PRESENILIN-2
P00056	VEGF signaling pathway	P01414	PLC-gamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CANLF|Ensembl=ENSCAFG00000018564|UniProtKB=E2RHU1	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	IC	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00059	p53 pathway	P04633	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00256	PLC-gamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	CHICK|Ensembl=ENSGALG00000014365|UniProtKB=F1NIJ8	Uncharacterized protein	ISS	9043084	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00057	Wnt signaling pathway	P01438	PP2A	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CHICK|Gene=MYH3|UniProtKB=P02565	Myosin-1B	IC	10938134	PubMed	PTHR13140:SF657	MYOSIN-4
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04550	Ral	XENTR|Xenbase=XB-GENE-485016|UniProtKB=Q28CF3	Uncharacterized protein	ISS	11025226	PubMed	PTHR24070:SF174	RAS-RELATED PROTEIN RAL-A
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00747	Rhodopsin	DROME|FlyBase=FBgn0003248|UniProtKB=P08099	Opsin Rh2	ISS	1634520	PubMed	PTHR24243:SF121	LEUCOKININ RECEPTOR-RELATED
P00029	Huntington disease	P00786	ARF	TAKRU|Ensembl=ENSTRUG00000017307|UniProtKB=H2VAQ1	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00019	Endothelin signaling pathway	P00566	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00035	Interferon-gamma signaling pathway	P00956	SOCS	MOUSE|MGI=MGI=1924885|UniProtKB=Q9JLY0	Suppressor of cytokine signaling 6	TAS	12645661	PubMed	PTHR44562:SF1	SUPPRESSOR OF CYTOKINE SIGNALING 6
P04393	Ras Pathway	P04542	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MONDO|Ensembl=ENSMODG00000003363|UniProtKB=F7CB79	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	CANLF|Ensembl=ENSCAFG00000004767|UniProtKB=E2RAV2	Uncharacterized protein	ISS			PTHR11405:SF5	CAD PROTEIN
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00018	EGF receptor signaling pathway	G01511	SPRY	BOVIN|Ensembl=ENSBTAG00000010245|UniProtKB=F1MIH6	Uncharacterized protein	ISS			PTHR12365:SF9	PROTEIN SPROUTY HOMOLOG 3
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	HUMAN|HGNC=9565|UniProtKB=P51665	26S proteasome non-ATPase regulatory subunit 7	ISS	95275316	PubMed	PTHR10540:SF7	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7
P06664	Gonadotropin-releasing hormone receptor pathway	P06834	MAP3Ks	MOUSE|MGI=MGI=1346876|UniProtKB=O35099	Mitogen-activated protein kinase kinase kinase 5	RCA	11730323	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P02723	Adenine and hypoxanthine salvage pathway	P02810	Adenine phosphoribosyl transferase	BACSU|EnsemblGenome=BSU22070|UniProtKB=P42085	Xanthine phosphoribosyltransferase	ISS			PTHR43864:SF1	SUBFAMILY NOT NAMED
P00020	FAS signaling pathway	P00602	DAXX	RAT|RGD=621227|UniProtKB=Q8VIB2	Death domain-associated protein 6	IGI	9215629	PubMed	PTHR12766:SF7	DEATH DOMAIN-ASSOCIATED PROTEIN 6
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	ANOGA|EnsemblGenome=AGAP005912|UniProtKB=Q7Q6D3	AGAP005912-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	STRPU|EnsemblGenome=SPU_018419|UniProtKB=W4YRI6	Uncharacterized protein	ISS	97210759	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P02749	Leucine biosynthesis	P03000	Branched chain amino acid aminotransferase	BOVIN|Ensembl=ENSBTAG00000009172|UniProtKB=Q5EA40	Branched-chain-amino-acid aminotransferase, mitochondrial	ISS			PTHR11825:SF39	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, MITOCHONDRIAL
P00047	PDGF signaling pathway	P01151	PKB	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00211	GSK3beta	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	ARATH|TAIR=AT2G36880|UniProtKB=Q9SJL8	S-adenosylmethionine synthase 3	ISS			PTHR11964:SF36	S-ADENOSYLMETHIONINE SYNTHASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00623	FGF	MOUSE|MGI=MGI=95517|UniProtKB=P05524	Fibroblast growth factor 3	IGI	12810586	PubMed	PTHR11486:SF26	FIBROBLAST GROWTH FACTOR 3
P04398	p53 pathway feedback loops 2	P04665	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	PANTR|Ensembl=ENSPTRG00000000290|UniProtKB=H2PY87	Cytidine deaminase	ISS	12844405	PubMed	PTHR11644:SF2	CYTIDINE DEAMINASE
P00012	Cadherin signaling pathway	P00475	Frizzled	MOUSE|MGI=MGI=1888513|UniProtKB=Q9JIP6	Frizzled-2	IDA	11212302	PubMed	PTHR11309:SF34	FRIZZLED-2
P00012	Cadherin signaling pathway	P00470	F-actin	ORYSJ|EnsemblGenome=OS11G0163100|UniProtKB=Q67G20	Actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00005	Angiogenesis	P00256	PLC-gamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IGI	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00564	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CANLF|Ensembl=ENSCAFG00000028654|UniProtKB=J9P702	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	HUMAN|HGNC=30829|UniProtKB=Q9BVA1	Tubulin beta-2B chain	ISS	9454836	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P02740	De novo pyrimidine ribonucleotides biosythesis	P02928	Dihydroorotase	HALSA|EnsemblGenome=VNG_2533G|UniProtKB=Q9HMH9	Dihydroorotase	ISS			PTHR43668:SF2	ALLANTOINASE
P00006	Apoptosis signaling pathway	P00260	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	RAT|RGD=621029|UniProtKB=Q924U0	Leukotriene B4 receptor 2	ISS	10934230	PubMed	PTHR24230:SF8	LEUKOTRIENE B4 RECEPTOR 2
P06587	Nicotine pharmacodynamics pathway	P06613	CHRNB2	PANTR|Ensembl=ENSPTRG00000001389|UniProtKB=H2Q056	Uncharacterized protein	ISS	15155845	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	HUMAN|HGNC=145|UniProtKB=P63267	Actin, gamma-enteric smooth muscle	IC	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000001583|UniProtKB=F7BBM1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	TAS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	ISS	10704417	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	TRYB2|Gene=Tb11.v4.0007|UniProtKB=Q382Q0	Ribonucleoside-diphosphate reductase small chain	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00012	Cadherin signaling pathway	P00463	betacatenin	MOUSE|MGI=MGI=88276|UniProtKB=Q02248	Catenin beta-1	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ARATH|TAIR=AT2G42100|UniProtKB=Q8RYC2	Putative actin-5	IC	14684598	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00048	PI3 kinase pathway	P01192	p110	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00572	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00049	Parkinson disease	P01219	SAPK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01444	Wnt	MONDO|Ensembl=ENSMODG00000015792|UniProtKB=Q2QL96	Protein Wnt-2	ISS	11266476	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MOUSE|MGI=MGI=101848|UniProtKB=P62881	Guanine nucleotide-binding protein subunit beta-5	ISS	10051575	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000032222|UniProtKB=F7FW05	Uncharacterized protein	ISS	14645495	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00029	Huntington disease	P00778	NMDA receptor	DANRE|ZFIN=ZDB-GENE-051202-1|UniProtKB=E7F101	Uncharacterized protein	ISS	14698601	PubMed	PTHR44391:SF2	SUBFAMILY NOT NAMED
P05918	p38 MAPK pathway	P06021	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DANRE|ZFIN=ZDB-GENE-040426-1489|UniProtKB=Q6PHV0	Syntaxin 3A	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00049	Parkinson disease	P01230	Src kinase	HUMAN|HGNC=6735|UniProtKB=P07948	Tyrosine-protein kinase Lyn	IDA	1371009	PubMed	PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00045	Notch signaling pathway	P01110	Presenilin	HUMAN|HGNC=9508|UniProtKB=P49768	Presenilin-1	IDA	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00021	FGF signaling pathway	P00645	Rac	DICPU|Gene=DICPUDRAFT_92985|UniProtKB=F1A084	Putative uncharacterized protein rac1A	ISS	4757952	gi	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	RCA	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00012	Cadherin signaling pathway	P00470	F-actin	XENTR|Xenbase=XB-GENE-490883|UniProtKB=Q6NVA9	Actin, cytoplasmic 1	ISS	11889139	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05915	Opioid proenkephalin pathway	P05989	leu-Enkephalin	DANRE|ZFIN=ZDB-GENE-030729-3|UniProtKB=F1QTD1	Uncharacterized protein (Fragment)	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00037	Ionotropic glutamate receptor pathway	P01001	KA4	MONDO|Ensembl=ENSMODG00000013079|UniProtKB=F7FB74	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P04398	p53 pathway feedback loops 2	P04657	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00046	Oxidative stress response	P01129	JNK1/2	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	TAS	10514528	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00049	Parkinson disease	P01219	SAPK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04625	Cdk2	TAKRU|Ensembl=ENSTRUG00000018471|UniProtKB=H2VDI9	Uncharacterized protein	ISS	15660127	PubMed	PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00029	Huntington disease	P00807	Actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347736|UniProtKB=E9FRT1	Muscle-specific actin	ISS	10974003	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04393	Ras Pathway	P04569	Cdc42	DAPPU|EnsemblGenome=DAPPUDRAFT_306746|UniProtKB=E9GYE9	Putative uncharacterized protein	ISS	9658176	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	97102671	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00048	PI3 kinase pathway	P01181	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	7667318	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00029	Huntington disease	P00796	Kainate receptor	CHICK|Ensembl=ENSGALG00000001172|UniProtKB=P19439	Probable glutamate receptor	IDA	11319238	PubMed	PTHR18966:SF282	GLUTAMATE RECEPTOR-RELATED
P04397	p53 pathway by glucose deprivation	P04647	LKB1	XENTR|Xenbase=XB-GENE-955279|UniProtKB=F6PM85	Uncharacterized protein	ISS			PTHR44214:SF1	SERINE/THREONINE-PROTEIN KINASE STK11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00865	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	95096035	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00057	Wnt signaling pathway	P01452	NFAT	MACMU|Ensembl=ENSMMUG00000021843|UniProtKB=F6RNI3	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	21588212	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00029	Huntington disease	P00775	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00049	Parkinson disease	P01242	Casein kinase I	SCHPO|PomBase=SPBP35G2.05c|UniProtKB=P40234	Casein kinase I homolog 2	IDA	10617630	PubMed	PTHR11909:SF155	GILGAMESH, ISOFORM L
P00035	Interferon-gamma signaling pathway	P00961	STAT1	HUMAN|HGNC=11362|UniProtKB=P42224	Signal transducer and activator of transcription 1-alpha/beta	TAS	14755057	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05915	Opioid proenkephalin pathway	P05994	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00010	B cell activation	P00391	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00009	Axon guidance mediated by netrin	P00366	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00034	Integrin signalling pathway	P00951	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00010	B cell activation	P00376	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	MACMU|Ensembl=ENSMMUG00000017985|UniProtKB=F7DN31	Uncharacterized protein	ISS	1904011	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00060	Ubiquitin proteasome pathway	P01490	E3	MOUSE|MGI=MGI=1914144|UniProtKB=Q9DBH0	NEDD4-like E3 ubiquitin-protein ligase WWP2	ISS			PTHR11254:SF396	NEDD4-LIKE E3 UBIQUITIN-PROTEIN LIGASE WWP2
P00005	Angiogenesis	P00247	Tie2	HUMAN|HGNC=11724|UniProtKB=Q02763	Angiopoietin-1 receptor	ISS	1630810	PubMed	PTHR24416:SF125	ANGIOPOIETIN-1 RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	TAS	88311074	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00048	PI3 kinase pathway	P01176	JAK	MACMU|Ensembl=ENSMMUG00000014558|UniProtKB=F7GT47	Tyrosine-protein kinase	ISS	22482294	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IDA	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P06959	CCKR signaling map	P07027	ICER	HUMAN|HGNC=2352|UniProtKB=Q03060	cAMP-responsive element modulator	RCA	10660591	PubMed	PTHR22952:SF97	CAMP-RESPONSIVE ELEMENT MODULATOR
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	IDA	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00019	Endothelin signaling pathway	P00577	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	TAS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00057	Wnt signaling pathway	P01451	Galpha	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	IDA	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04398	p53 pathway feedback loops 2	P04661	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00012	Cadherin signaling pathway	P00477	GSK3beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	MACMU|Ensembl=ENSMMUG00000001387|UniProtKB=F7D0B4	Uncharacterized protein	ISS	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00036	Interleukin signaling pathway	P00965	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05918	p38 MAPK pathway	P06026	MEKK4	MOUSE|MGI=MGI=1346875|UniProtKB=O08648	Mitogen-activated protein kinase kinase kinase 4	RCA	10207617	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00034	Integrin signalling pathway	P00916	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	87226391	PubMed	PTHR24070:SF385	GTPASE HRAS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00627	ERK1-2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	IXOSC|EnsemblGenome=ISCW024111|UniProtKB=B7PBG2	Actin, putative (Fragment)	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00182	p38MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01179	PKB	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00551	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01336	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04392	P53 pathway feedback loops 1	P04536	Mdm2	BOVIN|Gene=MDM4|UniProtKB=Q2HJ21	Protein Mdm4	ISS			PTHR13844:SF20	PROTEIN MDM4
P00053	T cell activation	P01311	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04376	5HT4 type receptor mediated signaling pathway	P04426	K+ channel	PANTR|Ensembl=ENSPTRG00000020614|UniProtKB=H2QWR7	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00865	Shc	MOUSE|MGI=MGI=98296|UniProtKB=P98083	SHC-transforming protein 1	ISS	10982827	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00056	VEGF signaling pathway	P01420	FAK	XENTR|Xenbase=XB-GENE-952025|UniProtKB=F7CW18	Uncharacterized protein	ISS	12640026	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00048	PI3 kinase pathway	P01202	p85	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	IC	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	PANTR|Ensembl=ENSPTRG00000002741|UniProtKB=H2Q292	Uncharacterized protein	ISS	12181435	PubMed	PTHR24247:SF116	5-HYDROXYTRYPTAMINE RECEPTOR 7
P00018	EGF receptor signaling pathway	P00544	c-Cbl	MOUSE|MGI=MGI=2146430|UniProtKB=Q3TTA7	E3 ubiquitin-protein ligase CBL-B	ISS	95303504	PubMed	PTHR23007:SF3	E3 UBIQUITIN-PROTEIN LIGASE CBL-B
P02772	Pyruvate metabolism	P03135	Phosphoenolpyruvate Carboxykinase	DROME|FlyBase=FBgn0003067|UniProtKB=P20007	Phosphoenolpyruvate carboxykinase [GTP]	TAS	87316942	PubMed	PTHR11561:SF0	PHOSPHOENOLPYRUVATE CARBOXYKINASE  GTP -RELATED
P05918	p38 MAPK pathway	P06031	p38alpha	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00057	Wnt signaling pathway	P01428	Frizzled	DANRE|ZFIN=ZDB-GENE-000328-4|UniProtKB=B0S6S2	Uncharacterized protein	IDA	11212302	PubMed	PTHR11309:SF90	FRIZZLED-8
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BOVIN|Ensembl=ENSBTAG00000006189|UniProtKB=P63258	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00021	FGF signaling pathway	P00648	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00005	Angiogenesis	P00254	GTPase	MOUSE|MGI=MGI=1914903|UniProtKB=Q9CR99	Protein 4930544G11Rik	ISS			PTHR24072:SF165	PROTEIN 4930544G11RIK
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	BRAFL|Gene=BRAFLDRAFT_118777|UniProtKB=C3ZB94	Putative uncharacterized protein	ISS			PTHR12458:SF8	CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20
P02772	Pyruvate metabolism	P03140	Pyruvate Carboxylase	CANLF|Ensembl=ENSCAFG00000012081|UniProtKB=F1P6G9	Pyruvate carboxylase	ISS	200246	gi	PTHR43778:SF2	PYRUVATE CARBOXYLASE, MITOCHONDRIAL
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00017	DNA replication	P00536	DNA Topisomerase	YEAST|SGD=S000005032|UniProtKB=P06786	DNA topoisomerase 2	ISS			PTHR10169:SF38	DNA TOPOISOMERASE 2
P02757	O-antigen biosynthesis	P03049	Glucosamine-1-phosphate acetyltransferase	PSEAE|EnsemblGenome=PA5552|UniProtKB=Q9HT22	Bifunctional protein GlmU	ISS			PTHR43584:SF3	BIFUNCTIONAL PROTEIN GLMU
P00047	PDGF signaling pathway	P01143	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00045	Notch signaling pathway	P01109	Aph-1	MACMU|Ensembl=ENSMMUG00000021386|UniProtKB=F7FDK4	Uncharacterized protein	ISS	12972157	PubMed	PTHR12889:SF3	GAMMA-SECRETASE SUBUNIT APH-1A
P02783	Tryptophan biosynthesis	P03206	Anthranilate synthase	SCHPO|PomBase=SPCC1442.09|UniProtKB=O94582	Probable anthranilate synthase component 1	ISS			PTHR11236:SF9	ANTHRANILATE SYNTHASE COMPONENT 1
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	NAS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00010	B cell activation	P00398	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P06959	CCKR signaling map	G07262	HDC	HUMAN|HGNC=4855|UniProtKB=P19113	Histidine decarboxylase	RCA	9142914	PubMed	PTHR11999:SF68	HISTIDINE DECARBOXYLASE
P00029	Huntington disease	P00786	ARF	RAT|RGD=2152|UniProtKB=P61214	ADP-ribosylation factor-like protein 4A	ISS	12932731	PubMed	PTHR11711:SF139	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 4A
P00029	Huntington disease	P00812	Caspase 3	TAKRU|Ensembl=ENSTRUG00000015915|UniProtKB=H2UUR6	Uncharacterized protein (Fragment)	IDA	11675509	PubMed	PTHR10454:SF198	CASPASE-3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	BOVIN|Ensembl=ENSBTAG00000005903|UniProtKB=F1N1K8	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	CHICK|Ensembl=ENSGALG00000013981|UniProtKB=Q9YGV8	TATA box-binding protein-like protein 1	ISS	600075	OMIM	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00059	p53 pathway	P04628	14-3-3	BOVIN|Ensembl=ENSBTAG00000009223|UniProtKB=Q0VC36	14-3-3 protein sigma	ISS			PTHR18860:SF14	14-3-3 PROTEIN SIGMA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BOVIN|Gene=ACTB|UniProtKB=P60712	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00025	Hedgehog signaling pathway	P00682	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00788	Calpain	MACMU|Ensembl=ENSMMUG00000018174|UniProtKB=F7EDT3	Uncharacterized protein	ISS	11675509	PubMed	PTHR10183:SF370	CALPAIN-5
P00057	Wnt signaling pathway	P01451	Galpha	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	IDA	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00005	Angiogenesis	P00223	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MACMU|Ensembl=ENSMMUG00000013031|UniProtKB=F7HAA9	Metalloendopeptidase	ISS	9759503	PubMed	PTHR43978:SF3	BONE MORPHOGENETIC PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DANRE|ZFIN=ZDB-GENE-030131-172|UniProtKB=Q6IQR3	Actin, alpha, cardiac muscle 1a	IC	10974003	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00018	EGF receptor signaling pathway	P00560	Raf-1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IGI	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	TAS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P02738	De novo purine biosynthesis	P02909	GDP reductase	AQUAE|EnsemblGenome=aq_094|UniProtKB=O66503	Ribonucleoside-diphosphate reductase subunit alpha	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PHYIT|EnsemblGenome=PITG_15117|UniProtKB=D0NRP9	Actin-like protein	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2520|UniProtKB=P61169	D(2) dopamine receptor	IDA	1319557	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00048	PI3 kinase pathway	P01178	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12162872	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00019	Endothelin signaling pathway	P00566	ERK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	IGI	9836510	gi	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00010	B cell activation	P00386	Calcineurin	PANTR|Ensembl=ENSPTRG00000016315|UniProtKB=H2QPY6	Serine/threonine-protein phosphatase	ISS	12091710	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHICK|Gene=ACTG2|UniProtKB=P63270	Actin, gamma-enteric smooth muscle	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00020	FAS signaling pathway	P00615	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	12855688	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00036	Interleukin signaling pathway	P00983	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IC	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	BOVIN|Ensembl=ENSBTAG00000035370|UniProtKB=Q32LB1	TATA box-binding protein-like protein 1	ISS	10082669	PubMed	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00012	Cadherin signaling pathway	P00475	Frizzled	XENTR|Xenbase=XB-GENE-478210|UniProtKB=F6V5F4	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF23	FRIZZLED-4
P04384	Gamma-aminobutyric acid synthesis	P04481	Succinic semialdehyde dehydrogenase	STRCO|Gene=CAD55522|UniProtKB=Q8CJL1	Succinate-semialdehyde dehydrogenase	IC	12891648	PubMed	PTHR43353:SF5	SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL
P05915	Opioid proenkephalin pathway	P05994	G-protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06769	Gbeta	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00005	Angiogenesis	P00219	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	88241036	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02746	Heme biosynthesis	P02972	Ferrochelatase	BACSU|EnsemblGenome=BSU10130|UniProtKB=P32396	Ferrochelatase	ISS			PTHR11108:SF1	FERROCHELATASE, MITOCHONDRIAL
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00005	Angiogenesis	P00181	SHP2	TAKRU|Ensembl=ENSTRUG00000018529|UniProtKB=H2VDZ2	Tyrosine-protein phosphatase non-receptor type	ISS	7681589	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00057	Wnt signaling pathway	P01465	Ggamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	YEAST|SGD=S000005600|UniProtKB=P06785	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00023	General transcription regulation	P00658	TBP-associated factors	HUMAN|HGNC=11544|UniProtKB=Q15544	Transcription initiation factor TFIID subunit 11	ISS			PTHR13218:SF16	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11
P00007	Axon guidance mediated by semaphorins	P00340	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00627	ERK1-2	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	NAS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00005	Angiogenesis	P00223	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01202	p85	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P02738	De novo purine biosynthesis	P02907	dADP kinase	SULSO|EnsemblGenome=SSO0230|UniProtKB=Q980Q7	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00029	Huntington disease	P00805	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04393	Ras Pathway	P04546	GSK3	PANTR|Ensembl=ENSPTRG00000011049|UniProtKB=H2QGF9	Glycogen synthase kinase 3 alpha	ISS	12086949	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00021	FGF signaling pathway	P00644	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	IDA	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04376	5HT4 type receptor mediated signaling pathway	P04427	5HT4 Receptor	HUMAN|HGNC=5299|UniProtKB=Q13639	5-hydroxytryptamine receptor 4	ISS	12181435	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CANLF|Ensembl=ENSCAFG00000005662|UniProtKB=E2R907	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00047	PDGF signaling pathway	P01153	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00009	Axon guidance mediated by netrin	P00364	cdc42	DAPPU|EnsemblGenome=DAPPUDRAFT_306746|UniProtKB=E9GYE9	Putative uncharacterized protein	ISS	9658176	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00010	B cell activation	P00384	p38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	IDA	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00007	Axon guidance mediated by semaphorins	P00341	Rho	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00046	Oxidative stress response	P01135	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	CANLF|Ensembl=ENSCAFG00000002960|UniProtKB=E2R521	Uncharacterized protein	ISS			PTHR10024:SF176	SYNAPTOTAGMIN-3
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IGI	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000025240|UniProtKB=F7A7I3	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000009766|UniProtKB=F6TFL4	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	XENTR|Ensembl=ENSXETG00000030140|UniProtKB=F7EP58	Uncharacterized protein (Fragment)	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00059	p53 pathway	G04694	p110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	CHICK|Ensembl=ENSGALG00000005139|UniProtKB=F1NW23	Clathrin heavy chain	IDA	9388255	PubMed	PTHR10292:SF7	CLATHRIN HEAVY CHAIN 1
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	MOUSE|MGI=MGI=1926879|UniProtKB=Q9EQH4	Transcription initiation factor TFIID subunit 8	ISS	604904	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00012	Cadherin signaling pathway	P00475	Frizzled	HUMAN|HGNC=4044|UniProtKB=O60353	Frizzled-6	IDA	8717036	PubMed	PTHR11309:SF75	FRIZZLED-6
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	SCHMA|EnsemblGenome=Smp_059340|UniProtKB=C4QDC7	Guanine nucleotide-binding protein G(S) subunit alpha (Adenylate cyclase-stimulating G alpha protein),putative	ISS			PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	XENTR|Xenbase=XB-GENE-960013|UniProtKB=F6U002	Uncharacterized protein	ISS			PTHR42884:SF13	NEUROENDOCRINE CONVERTASE 2
P00047	PDGF signaling pathway	P01153	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00056	VEGF signaling pathway	P01405	VRAP	PANTR|Ensembl=ENSPTRG00000001476|UniProtKB=H2R8K0	Uncharacterized protein	ISS	Q9NP31	SPACC	PTHR14388:SF9	SH2 DOMAIN-CONTAINING PROTEIN 2A
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00059	p53 pathway	G04702	p53	MACMU|Ensembl=ENSMMUG00000016466|UniProtKB=F7GBH1	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00047	PDGF signaling pathway	P01143	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05918	p38 MAPK pathway	P06031	p38alpha	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04393	Ras Pathway	P04567	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	YEAST|SGD=S000001855|UniProtKB=P60010	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00910	Grb2	BOVIN|Ensembl=ENSBTAG00000003707|UniProtKB=A6QLK6	GRB2-related adapter protein	ISS	9741627	PubMed	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	BOVIN|Ensembl=ENSBTAG00000018445|UniProtKB=E1BK87	Uncharacterized protein	ISS	11554554	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	HUMAN|HGNC=3023|UniProtKB=P14416	D(2) dopamine receptor	IDA	2039532	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	1171954	gi	PTHR10048:SF14	PI-3 KINASE
P00053	T cell activation	P01295	vav	PANTR|Ensembl=ENSPTRG00000010378|UniProtKB=H2QF58	Uncharacterized protein	ISS	14623913	PubMed	PTHR22826:SF112	PROTO-ONCOGENE VAV
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	DANRE|ZFIN=ZDB-GENE-980605-30|UniProtKB=Q9YHE8	Transcription factor 7-like 1-A	IEP	9118222	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00036	Interleukin signaling pathway	P00968	Ikk	PANTR|Ensembl=ENSPTRG00000033948|UniProtKB=H2RBD4	Conserved helix-loop-helix ubiquitous kinase	ISS	9346484	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00890	ELK	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	14670631	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00009	Axon guidance mediated by netrin	P00357	Netrin	MOUSE|MGI=MGI=105088|UniProtKB=O09118	Netrin-1	ISS	11356879	PubMed	PTHR10574:SF365	NETRIN-1
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	MONDO|Ensembl=ENSMODG00000019001|UniProtKB=F7CP86	Serine/threonine-protein phosphatase	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00005	Angiogenesis	P00193	SOS-1	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00053	T cell activation	P01330	IKK	PANTR|Ensembl=ENSPTRG00000033948|UniProtKB=H2RBD4	Conserved helix-loop-helix ubiquitous kinase	ISS	12235208	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00053	T cell activation	P01300	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	97442349	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	P04613	B99	HUMAN|HGNC=13698|UniProtKB=Q9NYZ3	G2 and S phase-expressed protein 1	TAS	12750368	PubMed	PTHR21584:SF10	G2 AND S PHASE-EXPRESSED PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00047	PDGF signaling pathway	P01155	Jak	MACMU|Ensembl=ENSMMUG00000018566|UniProtKB=F6YLX1	Tyrosine-protein kinase	ISS	9637709	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00056	VEGF signaling pathway	P01414	PLC-gamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	IDA	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=708420|UniProtKB=Q62688	Inactive phospholipase C-like protein 1	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P00018	EGF receptor signaling pathway	P00547	PP2A	ORNAN|Ensembl=ENSOANG00000009097|UniProtKB=F7G755	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P04398	p53 pathway feedback loops 2	P04666	cyclin A	CHICK|Ensembl=ENSGALG00000011881|UniProtKB=F1NJI2	Uncharacterized protein	ISS			PTHR10177:SF69	CYCLIN-A2
P00005	Angiogenesis	P00219	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00034	Integrin signalling pathway	P00936	PI3K	ARATH|TAIR=AT1G60490|UniProtKB=P42339	Phosphatidylinositol 3-kinase VPS34	IPI	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00048	PI3 kinase pathway	P01199	Galpha	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IC	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8711|UniProtKB=Q9UN71	Protocadherin gamma-B4	IDA	8120095	PubMed	PTHR24028:SF117	PROTOCADHERIN GAMMA-B4
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00029	Huntington disease	P00778	NMDA receptor	HUMAN|HGNC=4588|UniProtKB=O15399	Glutamate receptor ionotropic, NMDA 2D	IDA	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00036	Interleukin signaling pathway	P00973	PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00624	14-3-3	DANRE|ZFIN=ZDB-GENE-061023-2|UniProtKB=E7F354	Uncharacterized protein	ISS	91108808	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00923	Arf1	ARATH|TAIR=AT1G10630|UniProtKB=Q6ID97	ADP-ribosylation factor A1F	ISS	12932731	PubMed	PTHR11711:SF210	ADP-RIBOSYLATION FACTOR 2-A-RELATED
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	CANAL|CGD=CAL0001524|UniProtKB=Q5A0N3	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CANLF|Ensembl=ENSCAFG00000031321|UniProtKB=J9NZJ2	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P00034	Integrin signalling pathway	P00931	Integrin beta	MACMU|Ensembl=ENSMMUG00000003289|UniProtKB=F7FG54	Integrin beta	ISS	4206165	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00012	Cadherin signaling pathway	P00470	F-actin	PANTR|Ensembl=ENSPTRG00000009762|UniProtKB=H2QE24	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P05918	p38 MAPK pathway	P06034	MKK4	CHICK|Ensembl=ENSGALG00000001001|UniProtKB=F1P3T1	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00012	Cadherin signaling pathway	P00471	Cadherin	MONDO|Ensembl=ENSMODG00000010471|UniProtKB=F7ET26	Uncharacterized protein (Fragment)	ISS	8120095	PubMed	PTHR43912:SF3	PROTOCADHERIN-1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MACMU|Ensembl=ENSMMUG00000018272|UniProtKB=F7HEB8	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MACMU|Ensembl=ENSMMUG00000011466|UniProtKB=F7B2R8	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P06959	CCKR signaling map	P07044	CDC42-GDP	HUMAN|HGNC=1736|UniProtKB=P60953	Cell division control protein 42 homolog	RCA	15331357	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	MACMU|Ensembl=ENSMMUG00000022578|UniProtKB=F7BKQ5	Uncharacterized protein	ISS	11679592	PubMed	PTHR23122:SF40	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=621254|UniProtKB=A0A0G2K5L1	Protein Fat1	IDA	8120095	PubMed	PTHR24026:SF42	PROTOCADHERIN FAT 1
P00004	Alzheimer disease-presenilin pathway	P00125	Ire-1 C-terminal fragment	HUMAN|HGNC=3449|UniProtKB=O75460	Serine/threonine-protein kinase/endoribonuclease IRE1	IDA	10619423	PubMed	PTHR13954:SF17	SERINE/THREONINE-PROTEIN KINASE/ENDORIBONUCLEASE IRE1
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00627	ERK1-2	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01319	PAK	BOVIN|Ensembl=ENSBTAG00000010191|UniProtKB=Q08E52	Serine/threonine-protein kinase PAK 1	ISS	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=103077|UniProtKB=Q64704	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	CHICK|Ensembl=ENSGALG00000010772|UniProtKB=F1P0L1	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF26	REGULATOR OF G-PROTEIN SIGNALING 7
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	PANTR|Ensembl=ENSPTRG00000012931|UniProtKB=H2QJF8	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	10693759	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01082	AC	RAT|RGD=708450|UniProtKB=Q9Z286	Adenylate cyclase type 10	IC	11744988	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CANLF|Ensembl=ENSCAFG00000016020|UniProtKB=O18840	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04542	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00012	Cadherin signaling pathway	P00475	Frizzled	MOUSE|MGI=MGI=2136761|UniProtKB=Q8BKG4	Frizzled-10	ISS	8717036	PubMed	PTHR11309:SF86	FRIZZLED-10
P05915	Opioid proenkephalin pathway	P05995	proenkephalin	HUMAN|HGNC=8831|UniProtKB=P01210	Proenkephalin-A	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00057	Wnt signaling pathway	P01438	PP2A	ORNAN|Ensembl=ENSOANG00000005732|UniProtKB=F6X0X1	Uncharacterized protein	ISS	8576224	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P02779	Thiamin biosynthesis	P03175	1-Deoxyxylulose-5-phosphate synthase	ARATH|TAIR=AT5G11380|UniProtKB=Q9LFL9	1-D-deoxyxylulose 5-phosphate synthase-like protein	ISS			PTHR43322:SF3	1-D-DEOXYXYLULOSE 5-PHOSPHATE SYNTHASE-LIKE PROTEIN
P00047	PDGF signaling pathway	P01159	SOS	DROME|FlyBase=FBgn0001965|UniProtKB=P26675	Protein son of sevenless	ISS	8479536	PubMed	PTHR23113:SF99	PROTEIN SON OF SEVENLESS
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00059	p53 pathway	P04622	Sin3	HUMAN|HGNC=19353|UniProtKB=Q96ST3	Paired amphipathic helix protein Sin3a	ISS	10441327	PubMed	PTHR12346:SF2	PAIRED AMPHIPATHIC HELIX PROTEIN SIN3A
P00010	B cell activation	P00402	Jnk	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PRIPA|Gene=PPA23459|UniProtKB=H3FMF2	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	BOVIN|Ensembl=ENSBTAG00000047202|UniProtKB=G3N3K3	Uncharacterized protein	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P05731	GABA-B receptor II signaling	P05755	Gbeta	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	DANRE|ZFIN=ZDB-GENE-020125-5|UniProtKB=A2CG69	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF356	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000000223|UniProtKB=F6XHK8	Uncharacterized protein	ISS	12441358	PubMed	PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	SCHPO|PomBase=SPAC8C9.03|UniProtKB=P36600	cAMP-dependent protein kinase regulatory subunit	IC	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00078	Alpha1A/1B/1C	PANTR|Ensembl=ENSPTRG00000017482|UniProtKB=H2QRX4	Uncharacterized protein	ISS	11781138	PubMed	PTHR24248:SF17	ALPHA-1B ADRENERGIC RECEPTOR
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00297	NFkappaB	HUMAN|HGNC=9954|UniProtKB=Q04864	Proto-oncogene c-Rel	ISS			PTHR24169:SF4	PROTO-ONCOGENE C-REL
P00057	Wnt signaling pathway	P01438	PP2A	CANLF|Ensembl=ENSCAFG00000014047|UniProtKB=F1PV54	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01227	20S proteasome	BOVIN|Ensembl=ENSBTAG00000000990|UniProtKB=Q3T0Y5	Proteasome subunit alpha type-2	ISS	12859888	PubMed	PTHR11599:SF16	PROTEASOME SUBUNIT ALPHA TYPE-2
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00383	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	RAT|RGD=69319|UniProtKB=P54313	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00018	EGF receptor signaling pathway	P00556	PLCgamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00021	FGF signaling pathway	P00646	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	8270251	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	IC	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00029	Huntington disease	P00796	Kainate receptor	DANRE|Ensembl=ENSDARG00000070511|UniProtKB=E7F5R2	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF282	GLUTAMATE RECEPTOR-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00627	ERK1-2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00381	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04566	Stat 1/3	MOUSE|MGI=MGI=103038|UniProtKB=P42227	Signal transducer and activator of transcription 3	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04393	Ras Pathway	P04548	ATF2	MOUSE|MGI=MGI=109349|UniProtKB=P16951	Cyclic AMP-dependent transcription factor ATF-2	IDA	10664585	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	TAS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	IC	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	HUMAN|HGNC=414|UniProtKB=P04075	Fructose-bisphosphate aldolase A	ISS	74094688	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00054	Toll receptor signaling pathway	P01358	ERK1	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00007	Axon guidance mediated by semaphorins	P00340	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12676940	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P02772	Pyruvate metabolism	P03132	Pyruvate Kinase	MOUSE|MGI=MGI=97591|UniProtKB=P52480	Pyruvate kinase PKM	TAS	8193145	PubMed	PTHR11817:SF15	PYRUVATE KINASE PKM
P04393	Ras Pathway	P04543	MEKK1/4	MONDO|Ensembl=ENSMODG00000006594|UniProtKB=F7AKA6	Uncharacterized protein	ISS	12878610	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P05913	Enkephalin release	P05977	G-Protein (s)	DROME|FlyBase=FBgn0010223|UniProtKB=Q05337	Guanine nucleotide-binding protein G(f) subunit alpha	IC			PTHR10218:SF229	GUANINE NUCLEOTIDE-BINDING PROTEIN G F  SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04566	Stat 1/3	MOUSE|MGI=MGI=103038|UniProtKB=P42227	Signal transducer and activator of transcription 3	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04546	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	HUMAN|HGNC=4583|UniProtKB=Q16478	Glutamate receptor ionotropic, kainate 5	ISS	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04398	p53 pathway feedback loops 2	P04665	AKT	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00221	JNK1	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	HUMAN|HGNC=6026|UniProtKB=P25024	C-X-C chemokine receptor type 1	ISS	6753456	gi	PTHR10489:SF916	C-X-C CHEMOKINE RECEPTOR TYPE 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00059	p53 pathway	P04612	HDAC1	CANLF|Ensembl=ENSCAFG00000010597|UniProtKB=J9NUI0	Histone deacetylase	ISS	12665570	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P00034	Integrin signalling pathway	P00949	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	7680960	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00010	B cell activation	P00373	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IGI	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00034	Integrin signalling pathway	P00927	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00019	Endothelin signaling pathway	P00570	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000007445|UniProtKB=F6SWI4	Uncharacterized protein	ISS	20088160	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	IDA	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00029	Huntington disease	G01531	BDNF	CHICK|Ensembl=ENSGALG00000012163|UniProtKB=P25429	Brain-derived neurotrophic factor	IDA	12117585	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00052	TGF-beta signaling pathway	P01279	Smurfs	CHICK|Ensembl=ENSGALG00000004655|UniProtKB=F1NFN4	Uncharacterized protein	ISS	11252892	PubMed	PTHR11254:SF293	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00057	Wnt signaling pathway	P01471	alpha-catenin	MACMU|Ensembl=ENSMMUG00000017985|UniProtKB=F7DN31	Uncharacterized protein	ISS	9362521	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	BOVIN|Gene=MMP20|UniProtKB=O18767	Matrix metalloproteinase-20	TAS	12834808	PubMed	PTHR10201:SF125	MATRIX METALLOPROTEINASE-20
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P02738	De novo purine biosynthesis	P02900	AICAR transformylase	DEIRA|EnsemblGenome=DR_0868|UniProtKB=Q9RW01	Bifunctional purine biosynthesis protein PurH	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9836512	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00005	Angiogenesis	P00219	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00036	Interleukin signaling pathway	P00965	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IC	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00631	Grb2	CAEBR|Gene=CBG16856|UniProtKB=A8XPY6	Protein CBR-SEM-5	ISS	4504111	gi	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00012	Cadherin signaling pathway	P00470	F-actin	DROME|FlyBase=FBgn0000046|UniProtKB=P10981	Actin-87E	IC	10974003	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00017	DNA replication	P00527	Histones	BRAFL|Gene=BRAFLDRAFT_97692|UniProtKB=C3YMG9	Histone H3	ISS	12413958	PubMed	PTHR11426:SF180	SUBFAMILY NOT NAMED
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	HUMAN|HGNC=129|UniProtKB=P68133	Actin, alpha skeletal muscle	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P04397	p53 pathway by glucose deprivation	P04641	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00941	Integrin alpha	MOUSE|MGI=MGI=96604|UniProtKB=P11688	Integrin alpha-5	IPI	3487386	PubMed	PTHR23220:SF3	INTEGRIN ALPHA-5
P00049	Parkinson disease	P01238	14-3-3	BOVIN|Ensembl=ENSBTAG00000002108|UniProtKB=Q3SZI4	14-3-3 protein theta	ISS	7603573	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04625	Cdk2	DANRE|ZFIN=ZDB-GENE-040426-2741|UniProtKB=Q7ZWB1	Cyclin-dependent kinase 2	ISS	1846803	PubMed	PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	RAT|RGD=3697|UniProtKB=P31596	Excitatory amino acid transporter 2	IC	94365697	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P00046	Oxidative stress response	P01130	CHOP	MACMU|Ensembl=ENSMMUG00000011286|UniProtKB=F6WA37	DNA damage-inducible transcript 3 protein	ISS	10207617	PubMed	PTHR16833:SF0	DNA DAMAGE-INDUCIBLE TRANSCRIPT 3 PROTEIN
P00009	Axon guidance mediated by netrin	P00359	NFAT	PANTR|Ensembl=ENSPTRG00000013628|UniProtKB=H2R4F5	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PHYPA|Gene=PHYPADRAFT_172686|UniProtKB=A9TYG6	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04393	Ras Pathway	P04572	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MONDO|Ensembl=ENSMODG00000004422|UniProtKB=F6SCX2	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF344	MYOSIN-7
P00049	Parkinson disease	P01235	Fyn kinase	XENTR|Xenbase=XB-GENE-6053489|UniProtKB=F6S8L5	Tyrosine-protein kinase	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00036	Interleukin signaling pathway	P00970	Interleukin	HUMAN|HGNC=5977|UniProtKB=P40933	Interleukin-15	IDA	7568001	PubMed	PTHR45114:SF1	INTERLEUKIN-15
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05918	p38 MAPK pathway	P06041	Cdc42	DANRE|ZFIN=ZDB-GENE-030131-8783|UniProtKB=Q52WY2	Ras-like protein Cdc42a	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	ORNAN|Ensembl=ENSOANG00000007488|UniProtKB=F6RH86	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF317	MYOSIN-9
P00034	Integrin signalling pathway	P00907	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00777	CBP	ARATH|TAIR=AT1G79000|UniProtKB=Q9C5X9	Histone acetyltransferase HAC1	IDA	10664585	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ORYSJ|EnsemblGenome=OS03G0718100|UniProtKB=Q10DV7	Actin-1	IC	11889126	PubMed	PTHR11937:SF364	ACTIN-11
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MOUSE|MGI=MGI=104557|UniProtKB=P18654	Ribosomal protein S6 kinase alpha-3	ISS	2779569	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00053	T cell activation	P01331	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IDA	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00021	FGF signaling pathway	P00642	MEK1-2	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	ARATH|TAIR=AT2G21550|UniProtKB=Q9SIK4	Bifunctional dihydrofolate reductase-thymidylate synthase	ISS			PTHR11548:SF7	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	RAT|RGD=71083|UniProtKB=P30940	5-hydroxytryptamine receptor 1F	ISS	12181435	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	HUMAN|HGNC=10935|UniProtKB=Q05940	Synaptic vesicular amine transporter	ISS	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	CANLF|Ensembl=ENSCAFG00000015905|UniProtKB=E2QUH6	Uncharacterized protein	ISS	12464600	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00029	Huntington disease	P00810	GAPDH	CHLRE|EnsemblGenome=CHLREDRAFT_129019|UniProtKB=A8HP84	Glyceraldehyde-3-phosphate dehydrogenase	IPI			PTHR43148:SF5	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE GAPA1, CHLOROPLASTIC-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TRIAD|EnsemblGenome=TriadG35956|UniProtKB=Q7YTV5	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04375	5HT3 type receptor mediated signaling pathway	P04425	K+ channel	MOUSE|MGI=MGI=3521816|UniProtKB=Q3LS21	Potassium channel subfamily K member 9	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00049	Parkinson disease	P01211	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00017	DNA replication	P00530	Top	HUMAN|HGNC=11990|UniProtKB=Q02880	DNA topoisomerase 2-beta	RCA			PTHR10169:SF36	DNA TOPOISOMERASE 2-BETA
P00047	PDGF signaling pathway	P01160	IP3 receptor	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00005	Angiogenesis	P00219	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	MOUSE|MGI=MGI=95818|UniProtKB=Q61626	Glutamate receptor ionotropic, kainate 5	ISS	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P05918	p38 MAPK pathway	P06020	p38delta	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	RCA	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	MONDO|Ensembl=ENSMODG00000008920|UniProtKB=F7GL76	Uncharacterized protein	ISS	11404397	PubMed	PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=2652894|UniProtKB=Q80Y86	Mitogen-activated protein kinase 15	ISS	9891064	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	CHICK|Ensembl=ENSGALG00000002098|UniProtKB=F1P0L4	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MOUSE|MGI=MGI=95814|UniProtKB=Q60934	Glutamate receptor ionotropic, kainate 1	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00053	T cell activation	P01312	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00728	RhoGEF	MOUSE|MGI=MGI=1353510|UniProtKB=Q61210	Rho guanine nucleotide exchange factor 1	IDA	12024019	PubMed	PTHR12673:SF122	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 1
P00034	Integrin signalling pathway	P00944	Actin	MONDO|Ensembl=ENSMODG00000023202|UniProtKB=F7EU36	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P02738	De novo purine biosynthesis	P02889	dGDP kinase	DICDI|dictyBase=DDB_G0273069|UniProtKB=P22887	Nucleoside diphosphate kinase, cytosolic	ISS			PTHR11349:SF64	NUCLEOSIDE DIPHOSPHATE KINASE HOMOLOG 5
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CIOIN|Ensembl=ENSCING00000001377|UniProtKB=F6SDC9	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00047	PDGF signaling pathway	P01168	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MOUSE|MGI=MGI=1354730|UniProtKB=Q9Z2H2	Regulator of G-protein signaling 6	IDA	8756726	PubMed	PTHR10845:SF27	REGULATOR OF G-PROTEIN SIGNALING 6
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00053	T cell activation	P01300	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00021	FGF signaling pathway	P00632	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00634	MEKK1-5	PANTR|Ensembl=ENSPTRG00000009518|UniProtKB=H2QDN0	Mitogen-activated protein kinase kinase kinase 3	ISS	11730323	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P05731	GABA-B receptor II signaling	P05755	Gbeta	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	6264430	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04393	Ras Pathway	P04578	Rho	XENTR|Xenbase=XB-GENE-489222|UniProtKB=Q28GJ8	Ras homolog gene family, member A	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00053	T cell activation	P01324	rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00053	T cell activation	P01311	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01143	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01192	p110	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00547	PP2A	RAT|RGD=3381|UniProtKB=P62716	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	IXOSC|EnsemblGenome=ISCW009711|UniProtKB=B7Q3T6	THO complex subunit, putative	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	TAS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00025	Hedgehog signaling pathway	P00691	CBP	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00304	XIAP	HUMAN|HGNC=592|UniProtKB=P98170	E3 ubiquitin-protein ligase XIAP	ISS			PTHR10044:SF115	BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 8-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00010	B cell activation	P00368	vav	MACMU|Ensembl=ENSMMUG00000019714|UniProtKB=F7H0I2	Uncharacterized protein	ISS	14623913	PubMed	PTHR22826:SF97	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3
P00036	Interleukin signaling pathway	P00965	ERK	HUMAN|HGNC=6879|UniProtKB=Q16659	Mitogen-activated protein kinase 6	IC	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00012	Cadherin signaling pathway	P00463	betacatenin	RAT|RGD=70487|UniProtKB=Q9WU82	Catenin beta-1	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	NEUCR|EnsemblGenome=EFNCRG00000003822|UniProtKB=Q1K7J3	Syntaxin 2	IC			PTHR19957:SF147	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00970	Interleukin	MOUSE|MGI=MGI=96541|UniProtKB=P20109	Interleukin-13	IC	12589338	PubMed	PTHR45413:SF1	INTERLEUKIN-13
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00057	Wnt signaling pathway	P01443	Phospholipase C	DROME|FlyBase=FBgn0004611|UniProtKB=P25455	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II	IDA	12176394	PubMed	PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00551	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	IGI	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MONDO|Ensembl=ENSMODG00000021434|UniProtKB=F7CB49	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00385	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00005	Angiogenesis	P00238	Ras	DICDI|dictyBase=DDB_G0292996|UniProtKB=P03967	Ras-like protein rasD	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00059	p53 pathway	G04705	p48	MACMU|Ensembl=ENSMMUG00000022964|UniProtKB=F6ST49	DNA damage-binding protein 2	ISS	14560002	PubMed	PTHR15169:SF2	DNA DAMAGE-BINDING PROTEIN 2
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	TRYB2|Gene=TB927.1.2330|UniProtKB=Q4GYY6	Beta tubulin	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00010	B cell activation	P00376	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00029	Huntington disease	P00807	Actin	HUMAN|HGNC=132|UniProtKB=P60709	Actin, cytoplasmic 1	IDA	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	IC	91056091	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00010	B cell activation	P00384	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	RAT|RGD=1307994|UniProtKB=B6RK61	Myosin heavy chain 7B	ISS	89264452	PubMed	PTHR13140:SF358	MYOSIN-7B
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00049	Parkinson disease	P01219	SAPK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	NAS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MOUSE|MGI=MGI=103189|UniProtKB=Q10738	Matrilysin	IEP	12834808	PubMed	PTHR10201:SF143	MATRILYSIN
P00018	EGF receptor signaling pathway	P00550	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00012	Cadherin signaling pathway	P00463	betacatenin	BOVIN|Ensembl=ENSBTAG00000016420|UniProtKB=Q0VCX4	Catenin beta-1	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00029	Huntington disease	P00807	Actin	XENTR|Xenbase=XB-GENE-488998|UniProtKB=Q5BL41	Actin-related protein 2	ISS	11889126	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P05917	Opioid proopiomelanocortin pathway	P06009	K+ channel	MACMU|Ensembl=ENSMMUG00000005826|UniProtKB=F6VE51	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00021	FGF signaling pathway	P00631	Grb2	DANRE|ZFIN=ZDB-GENE-040426-1975|UniProtKB=Q6PC73	Growth factor receptor-bound protein 2	ISS	8479536	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	LEIMA|EnsemblGenome=LmjF.35.4010|UniProtKB=Q9GNR4	Protein kinase A catalytic subunit isoform 1	ISS	10218114	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	HUMAN|HGNC=1388|UniProtKB=O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	14624853	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	MOUSE|MGI=MGI=99659|UniProtKB=E9PZQ0	Ryanodine receptor 1	ISS	15858232	PubMed	PTHR13715:SF15	RYANODINE RECEPTOR 1
P00053	T cell activation	P01300	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	DROME|FlyBase=FBgn0004623|UniProtKB=P29829	Guanine nucleotide-binding protein subunit beta-2	IC			PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00049	Parkinson disease	P01242	Casein kinase I	PRIPA|Gene=PPA25500|UniProtKB=H3FT78	Uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P05917	Opioid proopiomelanocortin pathway	P06008	ACTH	XENTR|Xenbase=XB-GENE-483703|UniProtKB=Q5M8F2	Proopiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CAEEL|WormBase=WBGene00003171|UniProtKB=P12456	Tubulin beta-1 chain	ISS	12932731	PubMed	PTHR11588:SF255	TUBA7L PROTEIN
P00040	Metabotropic glutamate receptor group II pathway	G01540	BDNF	BOVIN|Ensembl=ENSBTAG00000008134|UniProtKB=Q95106	Brain-derived neurotrophic factor	ISS	12117585	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	MOUSE|MGI=MGI=2442093|UniProtKB=Q8BVM4	Antizyme inhibitor 2	ISS			PTHR11482:SF4	ANTIZYME INHIBITOR 2
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	MOUSE|MGI=MGI=2385191|UniProtKB=P62915	Transcription initiation factor IIB	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P02748	Isoleucine biosynthesis	P02997	Acetolactate synthase	CHLRE|EnsemblGenome=CHLREDRAFT_138180|UniProtKB=A8J1U3	Acetolactate synthase, large subunit	ISS			PTHR18968:SF112	ACETOLACTATE SYNTHASE, CHLOROPLASTIC
P00003	Alzheimer disease-amyloid secretase pathway	P00084	X11alpha	HUMAN|HGNC=579|UniProtKB=Q99767	Amyloid beta A4 precursor protein-binding family A member 2	IDA	9614075	PubMed	PTHR12345:SF12	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 2
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT1G18150|UniProtKB=Q9LM33	Mitogen-activated protein kinase 8	ISS	12787066	PubMed	PTHR24055:SF246	MITOGEN-ACTIVATED PROTEIN KINASE 15-RELATED
P00005	Angiogenesis	P00249	PAK	XENTR|Xenbase=XB-GENE-966302|UniProtKB=F6T2E7	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00005	Angiogenesis	P00240	FRS-2	BOVIN|Ensembl=ENSBTAG00000019155|UniProtKB=E1B7I9	Uncharacterized protein	ISS	10464310	PubMed	PTHR21258:SF40	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P06959	CCKR signaling map	P07067	AP2M1	HUMAN|HGNC=564|UniProtKB=Q96CW1	AP-2 complex subunit mu	RCA	18184106	PubMed	PTHR10529:SF236	AP-2 COMPLEX SUBUNIT MU
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	MOUSE|MGI=MGI=96575|UniProtKB=P15208	Insulin receptor	TAS	2983222	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=11332|UniProtKB=P32745	Somatostatin receptor type 3	IDA	12562507	PubMed	PTHR24229:SF42	SOMATOSTATIN RECEPTOR TYPE 3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00748	Gbeta5L	MOUSE|MGI=MGI=101848|UniProtKB=P62881	Guanine nucleotide-binding protein subunit beta-5	IDA	11313908	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00025	Hedgehog signaling pathway	P00691	CBP	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8667|UniProtKB=Q9Y5I0	Protocadherin alpha-13	IDA	8120095	PubMed	PTHR24028:SF101	PROTOCADHERIN ALPHA-13
P00047	PDGF signaling pathway	P01143	ERK	BOVIN|Ensembl=ENSBTAG00000005865|UniProtKB=G5E577	Uncharacterized protein	ISS	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	RAT|RGD=1311192|UniProtKB=A0A0G2K3R1	Protein Map3k4	ISS	9079650	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00046	Oxidative stress response	P01129	JNK1/2	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000017374|UniProtKB=F7H6T7	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CANLF|Ensembl=ENSCAFG00000003333|UniProtKB=F1PWT6	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00018	EGF receptor signaling pathway	P00564	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00019	Endothelin signaling pathway	P00572	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00020	FAS signaling pathway	P00616	Nuclear Lamin	MOUSE|MGI=MGI=96796|UniProtKB=P21619	Lamin-B2	TAS	11165516	PubMed	PTHR23239:SF152	LAMIN-B2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	XENTR|Xenbase=XB-GENE-5919679|UniProtKB=F6WET9	Uncharacterized protein	ISS			PTHR43893:SF11	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P06587	Nicotine pharmacodynamics pathway	P06605	KCNK3/9	HUMAN|HGNC=6278|UniProtKB=O14649	Potassium channel subfamily K member 3	RCA	15282272	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00030	Hypoxia response via HIF activation	P00824	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	TAS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	BOVIN|Gene=DRD2|UniProtKB=P20288	D(2) dopamine receptor	ISS	2137198	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	DANRE|ZFIN=ZDB-GENE-030102-4|UniProtKB=Q8AV68	Cholinergic receptor, nicotinic, beta polypeptide 3b	ISS	85270494	PubMed	PTHR18945:SF75	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-3
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	BOVIN|Ensembl=ENSBTAG00000003369|UniProtKB=E1BEH9	Uncharacterized protein	ISS			PTHR10024:SF252	SYNAPTOTAGMIN-12
P00021	FGF signaling pathway	P00645	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00054	Toll receptor signaling pathway	P01346	TLR	HUMAN|HGNC=15634|UniProtKB=Q9BXR5	Toll-like receptor 10	ISS			PTHR24365:SF23	TOLL-LIKE RECEPTOR 10
P00005	Angiogenesis	P00249	PAK	CHICK|Ensembl=ENSGALG00000008058|UniProtKB=F1N8W8	Uncharacterized protein	ISS	7559398	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01294	NFAT	MACMU|Ensembl=ENSMMUG00000021843|UniProtKB=F6RNI3	Uncharacterized protein	ISS	12787506	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	TAKRU|Ensembl=ENSTRUG00000007253|UniProtKB=H2SZQ1	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00747	Rhodopsin	ANOGA|EnsemblGenome=AGAP001161|UniProtKB=Q7PX14	AGAP001161-PA	ISS	1634520	PubMed	PTHR24240:SF85	OPSIN RH1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00828	Galphai	PHANO|EnsemblGenome=SNOG_10086|UniProtKB=Q0UDS8	G-alpha subunit	ISS			PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	IDA	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05730	Endogenous cannabinoid signaling	P05748	mGluR	MOUSE|MGI=MGI=1351342|UniProtKB=Q3UVX5	Metabotropic glutamate receptor 5	ISS	12351712	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00034	Integrin signalling pathway	P00941	Integrin alpha	HUMAN|HGNC=6144|UniProtKB=P53708	Integrin alpha-8	IPI	10778855	PubMed	PTHR23220:SF5	INTEGRIN ALPHA-8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	PANTR|Ensembl=ENSPTRG00000018764|UniProtKB=H2QU01	Uncharacterized protein	ISS	6382022	PubMed	PTHR15071:SF17	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
P00021	FGF signaling pathway	P00643	Raf-1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00210	eNOS	MONDO|Ensembl=ENSMODG00000003903|UniProtKB=F6S3S1	Nitric oxide synthase	ISS	9837777	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MONDO|Ensembl=ENSMODG00000018065|UniProtKB=F7G485	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00551	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00566	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	HALSA|EnsemblGenome=VNG_1089G|UniProtKB=Q9HQM6	Adenylosuccinate synthetase	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P02787	Vitamin B6 metabolism	P03244	Pyridoxal kinase	PANTR|Ensembl=ENSPTRG00000040962|UniProtKB=H2RGH3	Pyridoxal (Pyridoxine, vitamin B6) kinase	ISS	15082224	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P00035	Interferon-gamma signaling pathway	P00956	SOCS	MOUSE|MGI=MGI=2385459|UniProtKB=O54928	Suppressor of cytokine signaling 5	TAS	22247722	PubMed	PTHR44282:SF3	SUPPRESSOR OF CYTOKINE SIGNALING 5
P05912	Dopamine receptor mediated signaling pathway	P05953	EPB41L1	HUMAN|HGNC=3378|UniProtKB=Q9H4G0	Band 4.1-like protein 1	IPI	12181426	PubMed	PTHR23280:SF24	BAND 4.1-LIKE PROTEIN 1
P04393	Ras Pathway	P04557	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MOUSE|MGI=MGI=87902|UniProtKB=P68134	Actin, alpha skeletal muscle	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00012	Cadherin signaling pathway	P00467	alpha-catenin	RAT|RGD=1359485|UniProtKB=Q5U302	Catenin (Cadherin associated protein), alpha 1	ISS	9362521	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	RAT|RGD=2917|UniProtKB=P15127	Insulin receptor	ISS	2983222	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P05734	Synaptic vesicle trafficking	P05773	Munc13	MOUSE|MGI=MGI=1342278|UniProtKB=Q9Z1N9	Protein unc-13 homolog B	TAS	605836	OMIM	PTHR10480:SF8	PROTEIN UNC-13 HOMOLOG B
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	CANLF|Ensembl=ENSCAFG00000003271|UniProtKB=E2R889	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF39	BONE MORPHOGENETIC PROTEIN 10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Ensembl=ENSBTAG00000001067|UniProtKB=E1BAB4	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00056	VEGF signaling pathway	P01411	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00149	Pen-2	CAEEL|WormBase=WBGene00003975|UniProtKB=Q9U357	Gamma-secretase subunit pen-2	IDA	12110170	PubMed	PTHR16318:SF0	GAMMA-SECRETASE SUBUNIT PEN-2
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00054	Toll receptor signaling pathway	P01370	TAK1	HUMAN|HGNC=6859|UniProtKB=O43318	Mitogen-activated protein kinase kinase kinase 7	ISS	10683140	PubMed	PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P04397	p53 pathway by glucose deprivation	P04641	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00846	JAK	MONDO|Ensembl=ENSMODG00000015373|UniProtKB=F6WH53	Tyrosine-protein kinase	ISS	22482294	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00056	VEGF signaling pathway	P01401	HIF-1	BOVIN|Gene=HIF1A|UniProtKB=Q9XTA5	Hypoxia-inducible factor 1-alpha	ISS	14526383	PubMed	PTHR23043:SF7	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	HUMAN|HGNC=7172|UniProtKB=Q9Y5R2	Matrix metalloproteinase-24	TAS	12834808	PubMed	PTHR10201:SF138	MATRIX METALLOPROTEINASE-24
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	IDA	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	HUMAN|HGNC=6027|UniProtKB=P25025	C-X-C chemokine receptor type 2	IDA	10741397	PubMed	PTHR10489:SF689	C-X-C CHEMOKINE RECEPTOR TYPE 2
P05915	Opioid proenkephalin pathway	P05994	G-protein	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00047	PDGF signaling pathway	P01143	ERK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00012	Cadherin signaling pathway	P00466	EGFR	MACMU|Gene=EGFR|UniProtKB=P55245	Epidermal growth factor receptor	ISS	20540545	gi	PTHR24416:SF91	EPIDERMAL GROWTH FACTOR RECEPTOR
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	MONDO|Ensembl=ENSMODG00000020352|UniProtKB=F7FKB2	Uncharacterized protein	ISS	94365697	PubMed	PTHR11958:SF24	EXCITATORY AMINO ACID TRANSPORTER 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00019	Endothelin signaling pathway	P00580	ET-RA/B	RAT|RGD=2535|UniProtKB=P26684	Endothelin-1 receptor	IGI	12538737	PubMed	PTHR24243:SF31	ENDOTHELIN-1 RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00009	Axon guidance mediated by netrin	P00364	cdc42	IXOSC|EnsemblGenome=ISCW003614|UniProtKB=B7PHY7	Cdc42 protein, putative	ISS	15723050	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	BOVIN|Ensembl=ENSBTAG00000012687|UniProtKB=F1MV64	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000024992|UniProtKB=F6TUR3	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P05918	p38 MAPK pathway	P06031	p38alpha	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	RCA	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	DROME|FlyBase=FBgn0004623|UniProtKB=P29829	Guanine nucleotide-binding protein subunit beta-2	IC			PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00053	T cell activation	P01324	rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12874273	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00036	Interleukin signaling pathway	P00994	FKHRL1	HUMAN|HGNC=3821|UniProtKB=O43524	Forkhead box protein O3	TAS	14775847	gi	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00016	Cytoskeletal regulation by Rho GTPase	P00513	Op18/stathmin	MACMU|Ensembl=ENSMMUG00000000653|UniProtKB=F6WZM7	Stathmin	ISS	http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=3925	Website	PTHR10104:SF5	STATHMIN
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MONDO|Ensembl=ENSMODG00000008900|UniProtKB=F7B4C1	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	BOVIN|Gene=FURIN|UniProtKB=Q28193	Furin	IDA	10956649	PubMed	PTHR42884:SF1	FURIN
P00056	VEGF signaling pathway	P01425	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	10747026	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IDA	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P02744	Fructose galactose metabolism	P02966	Hexokinase	MOUSE|MGI=MGI=1315197|UniProtKB=O08528	Hexokinase-2	RCA			PTHR19443:SF4	HEXOKINASE-2
P00053	T cell activation	P01318	PKC-theta	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00059	p53 pathway	G04694	p110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00542	EGFR	RAT|RGD=620486|UniProtKB=Q62956	Receptor tyrosine-protein kinase erbB-4	IGI	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00036	Interleukin signaling pathway	P00968	Ikk	CANLF|Ensembl=ENSCAFG00000005526|UniProtKB=E2RKR0	Uncharacterized protein	ISS	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	DROME|FlyBase=FBgn0001991|UniProtKB=Q24270	Voltage-dependent calcium channel type D subunit alpha-1	IC	15621031	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IDA	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	MOUSE|MGI=MGI=109521|UniProtKB=P35363	5-hydroxytryptamine receptor 2A	ISS	8143856	PubMed	PTHR24247:SF30	5-HYDROXYTRYPTAMINE RECEPTOR 2A
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04398	p53 pathway feedback loops 2	P04658	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00045	Notch signaling pathway	P01105	TACE	CANLF|Ensembl=ENSCAFG00000003383|UniProtKB=F1PFZ9	Uncharacterized protein	ISS	9774383	PubMed	PTHR11905:SF171	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	8920915	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00107	kinesin	ORNAN|Ensembl=ENSOANG00000000786|UniProtKB=F6RDB4	Uncharacterized protein	ISS	11740561	PubMed	PTHR19959:SF203	KINESIN LIGHT CHAIN 1
P05731	GABA-B receptor II signaling	P05752	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00049	Parkinson disease	P01236	Casein kinase II	MACMU|Ensembl=ENSMMUG00000031224|UniProtKB=F7CKT2	Uncharacterized protein	ISS	10617630	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MONDO|Ensembl=ENSMODG00000021434|UniProtKB=F7CB49	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01177	P110ACT	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	IC	15210700	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00005	Angiogenesis	P00203	Erk	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	RAT|RGD=2733|UniProtKB=P42260	Glutamate receptor ionotropic, kainate 2	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P05913	Enkephalin release	P05972	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00054	Toll receptor signaling pathway	P01352	p38	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	XENTR|Xenbase=XB-GENE-494200|UniProtKB=F7CS79	Uncharacterized protein	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	MOUSE|MGI=MGI=99665|UniProtKB=O35681	Synaptotagmin-3	RCA			PTHR10024:SF176	SYNAPTOTAGMIN-3
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=7571|UniProtKB=Q9UKX3	Myosin-13	IC	89264452	PubMed	PTHR13140:SF504	MYOSIN-13
P04398	p53 pathway feedback loops 2	P04665	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02916	dTMP kinase	SYNY3|EnsemblGenome=BAA10099|UniProtKB=Q55593	Thymidylate kinase	ISS			PTHR10344:SF1	THYMIDYLATE KINASE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000010830|UniProtKB=E1BGJ0	Uncharacterized protein	ISS	11907044	PubMed	PTHR44025:SF2	PROLOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	ORNAN|Ensembl=ENSOANG00000008907|UniProtKB=F7EDR2	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	IDA	9094314	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	MOUSE|MGI=MGI=95811|UniProtKB=Q9Z2W8	Glutamate receptor 4	ISS	10331083	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00004	Alzheimer disease-presenilin pathway	P00163	Erb-B4 C-terminal fragment	HUMAN|HGNC=3432|UniProtKB=Q15303	Receptor tyrosine-protein kinase erbB-4	IDA	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	CAEEL|WormBase=WBGene00000222|UniProtKB=Q20435	ATF (CAMP-dependent transcription factor) family	ISS			PTHR22952:SF366	ATF  CAMP-DEPENDENT TRANSCRIPTION FACTOR  FAMILY
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04395	Vasopressin synthesis	P04590	Vasopressin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00029	Huntington disease	P00807	Actin	CIOIN|Ensembl=ENSCING00000001377|UniProtKB=F6SDC9	Uncharacterized protein	ISS			PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P04393	Ras Pathway	P04557	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	IDA	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00018	EGF receptor signaling pathway	P00549	EGF	RAT|RGD=2149|UniProtKB=P24338	Amphiregulin	IGI	2234093	PubMed	PTHR10740:SF12	AMPHIREGULIN
P04374	5HT2 type receptor mediated signaling pathway	P04413	K+ channel	HUMAN|HGNC=6283|UniProtKB=Q9NPC2	Potassium channel subfamily K member 9	ISS	15282272	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00057	Wnt signaling pathway	P01432	Beta-Catenin	CHICK|Ensembl=ENSGALG00000011905|UniProtKB=F1NHT7	Uncharacterized protein	IDA	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IGI	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MACMU|Ensembl=ENSMMUG00000010392|UniProtKB=F7ASR8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01095	beta	HUMAN|HGNC=1964|UniProtKB=P30926	Neuronal acetylcholine receptor subunit beta-4	ISS	22213672	PubMed	PTHR18945:SF385	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-4
P00056	VEGF signaling pathway	P01425	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	15572354	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00053	T cell activation	P01332	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	IDA	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	94179345	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00047	PDGF signaling pathway	P01153	GSK3	ORYSJ|EnsemblGenome=OS01G0296100|UniProtKB=Q94IZ2	Os01g0296100 protein	ISS	12615961	PubMed	PTHR24057:SF34	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00254	GTPase	DANRE|ZFIN=ZDB-GENE-040426-2150|UniProtKB=Q6NUX8	Rho-related GTP-binding protein RhoA-A	ISS	14871999	PubMed	PTHR24072:SF260	RHO-RELATED GTP-BINDING PROTEIN RHOA-A-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	DANRE|ZFIN=ZDB-GENE-040516-3|UniProtKB=Q6NSN6	Serine/threonine-protein phosphatase	ISS	10433257	PubMed	PTHR11668:SF191	SERINE/THREONINE-PROTEIN PHOSPHATASE
P05731	GABA-B receptor II signaling	P05755	Gbeta	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00510	mDia	PANTR|Ensembl=ENSPTRG00000022082|UniProtKB=H2R1G5	Uncharacterized protein	ISS			PTHR23213:SF174	PROTEIN DIAPHANOUS HOMOLOG 2
P00006	Apoptosis signaling pathway	P00310	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	LEIMA|EnsemblGenome=LmjF.35.3960|UniProtKB=E9AFM1	Protein kinase A catalytic subunit isoform 2	IC	10218114	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00011	Blood coagulation	P00442	FXII	HUMAN|HGNC=3530|UniProtKB=P00748	Coagulation factor XII	ISS	4503629	gi	PTHR44246:SF3	COAGULATION FACTOR XII
P00047	PDGF signaling pathway	P01161	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00029	Huntington disease	P00811	Arp2/3 complex	MOUSE|MGI=MGI=1928896|UniProtKB=Q9R0Q6	Actin-related protein 2/3 complex subunit 1A	TAS	12473693	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	CAEEL|WormBase=WBGene00002879|UniProtKB=P34346	Adenylate kinase	ISS			PTHR23359:SF117	ADENYLATE KINASE 2, MITOCHONDRIAL
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_114958|UniProtKB=C3XZ13	Putative uncharacterized protein	ISS			PTHR11937:SF359	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	CHICK|Ensembl=ENSGALG00000009320|UniProtKB=Q4JIM4	Presenilin-1	IDA	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P04393	Ras Pathway	P04565	MKK4/7	PANTR|Ensembl=ENSPTRG00000010409|UniProtKB=H2RBC8	Uncharacterized protein	ISS	15039780	PubMed	PTHR24361:SF387	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00010	B cell activation	P00372	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12186904	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	RAT|RGD=61862|UniProtKB=P19491	Glutamate receptor 2	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00021	FGF signaling pathway	P00644	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00010	B cell activation	P00384	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00048	PI3 kinase pathway	P01188	Gbetagamma	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00049	Parkinson disease	P01238	14-3-3	MONDO|Ensembl=ENSMODG00000006158|UniProtKB=F7BS95	Uncharacterized protein	ISS	12615066	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00012	Cadherin signaling pathway	P00475	Frizzled	BOVIN|Ensembl=ENSBTAG00000040128|UniProtKB=F1MLJ8	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF23	FRIZZLED-4
P00013	Cell cycle	P00480	Proteasome	DANRE|ZFIN=ZDB-GENE-030131-2711|UniProtKB=F6P3G4	26S proteasome non-ATPase regulatory subunit 11A	ISS	97227943	PubMed	PTHR10678:SF6	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11A
P00004	Alzheimer disease-presenilin pathway	P00127	APP	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P06587	Nicotine pharmacodynamics pathway	P06604	SLC18A2	HUMAN|HGNC=10935|UniProtKB=Q05940	Synaptic vesicular amine transporter	TAS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00054	Toll receptor signaling pathway	P01342	IRAK4	HUMAN|HGNC=17967|UniProtKB=Q9NWZ3	Interleukin-1 receptor-associated kinase 4	ISS			PTHR24419:SF22	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4
P00034	Integrin signalling pathway	P00907	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00006	Apoptosis signaling pathway	P00266	SEK1	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	TAS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000023202|UniProtKB=F7EU36	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00586	Gq	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00029	Huntington disease	P00807	Actin	CHICK|Ensembl=ENSGALG00000009844|UniProtKB=P68034	Actin, alpha cardiac muscle 1	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000003128|UniProtKB=H2Q2V4	Uncharacterized protein	ISS	11248120	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00056	VEGF signaling pathway	P01413	PI3K	CAEEL|WormBase=WBGene00006932|UniProtKB=Q9TXI7	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	21924698	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00021	FGF signaling pathway	P00632	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05915	Opioid proenkephalin pathway	P05994	G-protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01428	Frizzled	PANTR|Ensembl=ENSPTRG00000009279|UniProtKB=H2QD74	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF34	FRIZZLED-2
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00010	B cell activation	P00373	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00023	General transcription regulation	P00668	TFIIB	ORYSJ|EnsemblGenome=OS09G0534800|UniProtKB=Q8W0W3	Transcription initiation factor IIB	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	IDA	11790551	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00037	Ionotropic glutamate receptor pathway	P01015	Glu4	MACMU|Ensembl=ENSMMUG00000010987|UniProtKB=F7GCX9	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P04393	Ras Pathway	P04542	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	RAT|RGD=620351|UniProtKB=P18265	Glycogen synthase kinase-3 alpha	ISS	183955	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-8225|UniProtKB=Q7SZZ5	Uncharacterized protein	ISS			PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MONDO|Ensembl=ENSMODG00000016895|UniProtKB=F6XII5	Uncharacterized protein	ISS	10391901	PubMed	PTHR15936:SF2	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-13
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00052	TGF-beta signaling pathway	G01548	I-SMAD	CANLF|Ensembl=ENSCAFG00000019069|UniProtKB=F6XXN3	Mothers against decapentaplegic homolog	ISS	9335505	PubMed	PTHR13703:SF27	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 7
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g190658|UniProtKB=A7SJZ7	Predicted protein	ISS			PTHR12458:SF8	CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20
P02772	Pyruvate metabolism	P03137	Citrate Lyase	MACMU|Ensembl=ENSMMUG00000003558|UniProtKB=F7ETT5	Uncharacterized protein	ISS			PTHR11105:SF0	CITRATE LYASE SUBUNIT BETA-LIKE PROTEIN, MITOCHONDRIAL
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00019	Endothelin signaling pathway	P00566	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	LEIMA|EnsemblGenome=LmjF.35.4010|UniProtKB=Q9GNR4	Protein kinase A catalytic subunit isoform 1	IC	10218114	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	TRIAD|EnsemblGenome=TriadG63380|UniProtKB=B3S653	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04395	Vasopressin synthesis	P04597	Signal Peptide	BOVIN|Ensembl=ENSBTAG00000008026|UniProtKB=P01175	Oxytocin-neurophysin 1	ISS	1706187	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	CANLF|Ensembl=ENSCAFG00000004474|UniProtKB=E2RCN6	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00054	Toll receptor signaling pathway	P01346	TLR	CAEEL|WormBase=WBGene00006593|UniProtKB=Q9N5Z3	TOLl (Drosophila) family	ISS			PTHR44740:SF3	TOLL-LIKE RECEPTOR TOLLO
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DICDI|dictyBase=DDB_G0268744|UniProtKB=Q55EU6	Putative actin-23	IDA	11889126	PubMed	PTHR11937:SF154	ACTIN-17-RELATED
P00049	Parkinson disease	P01208	Hsp70	ORYSJ|EnsemblGenome=OS11G0703900|UniProtKB=Q53NM9	DnaK-type molecular chaperone hsp70-rice	IDA	12150907	PubMed	PTHR19375:SF325	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 37E-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000002658|UniProtKB=F7CB14	Uncharacterized protein	ISS	11248120	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00029	Huntington disease	P00778	NMDA receptor	BOVIN|Ensembl=ENSBTAG00000018445|UniProtKB=E1BK87	Uncharacterized protein	ISS	11319238	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IGI	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IPI	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00012	Cadherin signaling pathway	P00470	F-actin	CHICK|Gene=ACTA2|UniProtKB=P08023	Actin, aortic smooth muscle	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P05918	p38 MAPK pathway	P06020	p38delta	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	RCA	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04393	Ras Pathway	P04569	Cdc42	IXOSC|EnsemblGenome=ISCW003614|UniProtKB=B7PHY7	Cdc42 protein, putative	ISS	15723050	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00034	Integrin signalling pathway	P00951	Jnk	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IDA	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00053	T cell activation	P01336	Jnk	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00037	Ionotropic glutamate receptor pathway	P01026	KA	HUMAN|HGNC=4583|UniProtKB=Q16478	Glutamate receptor ionotropic, kainate 5	ISS	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00019	Endothelin signaling pathway	P00572	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00046	Oxidative stress response	P01126	ATF2	PANTR|Ensembl=ENSPTRG00000012660|UniProtKB=H2QJ07	Activating transcription factor 2	ISS	11390664	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	HUMAN|HGNC=4037|UniProtKB=P06241	Tyrosine-protein kinase Fyn	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00018	EGF receptor signaling pathway	P00546	GAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	14707121	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00572	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IGI	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00046	Oxidative stress response	P01129	JNK1/2	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00633	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9407|UniProtKB=Q15139	Serine/threonine-protein kinase D1	IGI	12393506	PubMed	PTHR22968:SF9	SERINE/THREONINE-PROTEIN KINASE D1
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	DICDI|dictyBase=DDB_G0292996|UniProtKB=P03967	Ras-like protein rasD	ISS	6091907	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00034	Integrin signalling pathway	P00912	Arp2/3	XENTR|Xenbase=XB-GENE-491571|UniProtKB=F6WW07	Uncharacterized protein (Fragment)	ISS	12473693	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	RAT|RGD=69319|UniProtKB=P54313	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=1352756|UniProtKB=Q8K394	Inactive phospholipase C-like protein 2	ISS			PTHR10336:SF84	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2
P00006	Apoptosis signaling pathway	P00310	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IDA	7937853	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00045	Notch signaling pathway	P01099	Notch	MACMU|Ensembl=ENSMMUG00000017022|UniProtKB=F7HQZ9	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	CHICK|Ensembl=ENSGALG00000010812|UniProtKB=F1NLZ9	Uncharacterized protein	ISS	15226293	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00021	FGF signaling pathway	P00644	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00018	EGF receptor signaling pathway	P00551	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=1921305|UniProtKB=Q8K4S1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	12176394	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00006	Apoptosis signaling pathway	P00276	TRAIL-R	HUMAN|HGNC=11905|UniProtKB=O14763	Tumor necrosis factor receptor superfamily member 10B	IDA	9242611	PubMed	PTHR23097:SF88	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10B
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00623	FGF	HUMAN|HGNC=3674|UniProtKB=O76093	Fibroblast growth factor 18	ISS	20368156	PubMed	PTHR11486:SF4	FIBROBLAST GROWTH FACTOR 18
P00005	Angiogenesis	P00226	Delta/Serrate	RAT|RGD=2938|UniProtKB=P97607	Protein jagged-2 (Fragment)	ISS	12826675	PubMed	PTHR44097:SF1	PROTEIN JAGGED-2
P00034	Integrin signalling pathway	P00907	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01431	LRP5/6	PANTR|Ensembl=ENSPTRG00000003983|UniProtKB=H2Q4A0	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00018	EGF receptor signaling pathway	P00552	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00010	B cell activation	P00367	NFAT	HUMAN|HGNC=7775|UniProtKB=O95644	Nuclear factor of activated T-cells, cytoplasmic 1	IDA	9462517	PubMed	PTHR12533:SF5	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00633	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00034	Integrin signalling pathway	P00920	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00057	Wnt signaling pathway	P01438	PP2A	DANRE|ZFIN=ZDB-GENE-040426-2487|UniProtKB=Q803G3	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01189	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	TAS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	DANRE|ZFIN=ZDB-GENE-020125-3|UniProtKB=E7F1V8	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00046	Oxidative stress response	P01131	MKP5	HUMAN|HGNC=3072|UniProtKB=Q16828	Dual specificity protein phosphatase 6	TAS			PTHR10159:SF45	DUAL SPECIFICITY PROTEIN PHOSPHATASE 6
P00009	Axon guidance mediated by netrin	P00363	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00029	Huntington disease	P00796	Kainate receptor	TAKRU|Ensembl=ENSTRUG00000009259|UniProtKB=H2TF39	Uncharacterized protein	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00012	Cadherin signaling pathway	P00474	Wnt	BOVIN|Gene=WNT16|UniProtKB=Q5E9U6	Protein Wnt-16	ISS	11266476	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P00014	Cholesterol biosynthesis	P00498	Hydroxymethyl glutaryl CoA synthase	BOVIN|Ensembl=ENSBTAG00000011839|UniProtKB=F6RJG0	Uncharacterized protein	ISS	600234	OMIM	PTHR43323:SF4	HYDROXYMETHYLGLUTARYL-COA SYNTHASE, CYTOPLASMIC
P00057	Wnt signaling pathway	P01450	Bcl9	RAT|RGD=1306934|UniProtKB=D4A7D6	Protein Bcl9	ISS	11955446	PubMed	PTHR15185:SF5	B-CELL CLL/LYMPHOMA 9 PROTEIN
P04393	Ras Pathway	P04548	ATF2	HUMAN|HGNC=784|UniProtKB=P15336	Cyclic AMP-dependent transcription factor ATF-2	ISS	7875593	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00053	T cell activation	P01306	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P02738	De novo purine biosynthesis	P02907	dADP kinase	MOUSE|MGI=MGI=1930182|UniProtKB=Q9WV85	Nucleoside diphosphate kinase 3	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P00011	Blood coagulation	P00449	GP Ibalpha	PANTR|Ensembl=ENSPTRG00000031002|UniProtKB=H2R9U1	Uncharacterized protein	ISS	91271273	PubMed	PTHR45534:SF1	PLATELET GLYCOPROTEIN IB ALPHA CHAIN
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	HUMAN|HGNC=4579|UniProtKB=P39086	Glutamate receptor ionotropic, kainate 1	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00055	Transcription regulation by bZIP transcription factor	P01392	TFIIH complex	NEUCR|EnsemblGenome=EFNCRG00000006577|UniProtKB=Q9P5N7	Putative RNA polymerase II transcription factor B subunit 1	ISS			PTHR12856:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 1
P00004	Alzheimer disease-presenilin pathway	P00111	C99	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	TAKRU|Ensembl=ENSTRUG00000010579|UniProtKB=H2TPU7	Uncharacterized protein	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00034	Integrin signalling pathway	P00951	Jnk	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00045	Notch signaling pathway	P01107	Fringe	DANRE|ZFIN=ZDB-GENE-980605-16|UniProtKB=Q8JHF2	Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe	ISS			PTHR10811:SF7	BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE LUNATIC FRINGE
P00047	PDGF signaling pathway	P01153	GSK3	CAEEL|WormBase=WBGene00001746|UniProtKB=Q9U2Q9	Glycogen synthase kinase-3	ISS	21361340	gi	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00034	Integrin signalling pathway	P00920	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00057	Wnt signaling pathway	P01446	Calcineurin	SCHMA|EnsemblGenome=Smp_064950|UniProtKB=G4VPT6	Putative calcineurin B	IDA	12015605	PubMed	PTHR23056:SF4	PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00053	T cell activation	P01335	jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00010	B cell activation	P00391	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00974	Receptor subunit beta	PANTR|Ensembl=ENSPTRG00000013866|UniProtKB=H2R1R1	Uncharacterized protein	ISS			PTHR20859:SF50	INTERLEUKIN-10 RECEPTOR SUBUNIT BETA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00274	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	MOUSE|MGI=MGI=94924|UniProtKB=P61168	D(2) dopamine receptor	ISS	11248120	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	RAT|RGD=619978|UniProtKB=P67874	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IGI	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00059	p53 pathway	P04635	Sumo-1 ligase	BOVIN|Ensembl=ENSBTAG00000009859|UniProtKB=Q5E9D1	Small ubiquitin-related modifier 1	ISS			PTHR10562:SF52	SMALL UBIQUITIN-RELATED MODIFIER 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PANTR|Ensembl=ENSPTRG00000018890|UniProtKB=Q5R1X3	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00005	Angiogenesis	P00221	JNK1	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04543	MEKK1/4	MACMU|Ensembl=ENSMMUG00000012387|UniProtKB=F7EB20	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00056	VEGF signaling pathway	P01407	Erk	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	BOVIN|Ensembl=ENSBTAG00000004279|UniProtKB=P61585	Transforming protein RhoA	ISS	12169092	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	HUMAN|HGNC=17031|UniProtKB=Q8WTQ7	Rhodopsin kinase	RCA			PTHR24355:SF12	RHODOPSIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Gene=PLCD4|UniProtKB=P21671	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	12860966	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00048	PI3 kinase pathway	P01177	P110ACT	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	12846562	PubMed	PTHR10202:SF13	PRESENILIN-2
P00010	B cell activation	P00373	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IGI	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00006	Apoptosis signaling pathway	P00274	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CHICK|Ensembl=ENSGALG00000008898|UniProtKB=F1P2J9	Uncharacterized protein	IC	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=11438|UniProtKB=Q13277	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00011	Blood coagulation	P00406	Fibrinogen	MACMU|Ensembl=ENSMMUG00000021304|UniProtKB=F6UYY8	Uncharacterized protein	ISS	223170	gi	PTHR19143:SF338	FIBRINOGEN GAMMA CHAIN
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	HUMAN|HGNC=4586|UniProtKB=Q13224	Glutamate receptor ionotropic, NMDA 2B	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00059	p53 pathway	G04690	PAG608	HUMAN|HGNC=29983|UniProtKB=Q9HA38	Zinc finger matrin-type protein 3	ISS			PTHR23067:SF5	ZINC FINGER MATRIN-TYPE PROTEIN 3
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	CAEEL|WormBase=WBGene00001187|UniProtKB=Q8MQA1	Uncharacterized protein	IDA			PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00054	Toll receptor signaling pathway	G01550	Gene trancription	PANTR|Ensembl=ENSPTRG00000001786|UniProtKB=H2Q0S9	Prostaglandin-endoperoxide synthase 2 (Prostaglandin G/H synthase and cyclooxygenase)	ISS	97393071	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	THEMA|EnsemblGenome=TM_0813|UniProtKB=Q9WZS0	Glucosamine-6-phosphate deaminase [isomerizing], alternative	ISS			PTHR10937:SF4	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04567	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IDA	96009592	PubMed	PTHR10048:SF14	PI-3 KINASE
P00034	Integrin signalling pathway	P00916	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00559	MEK1-2	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00047	PDGF signaling pathway	P01161	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00049	Parkinson disease	P01238	14-3-3	PANTR|Ensembl=ENSPTRG00000011641|UniProtKB=H2QHF1	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	ISS	7603573	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	RAT|RGD=2348|UniProtKB=Q05941	Neuronal acetylcholine receptor subunit alpha-7	ISS	85270494	PubMed	PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P00010	B cell activation	P00384	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01154	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00021	FGF signaling pathway	P00628	JNK1-3	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CHICK|Ensembl=ENSGALG00000013781|UniProtKB=F1P1D5	Uncharacterized protein	IC	89264452	PubMed	PTHR13140:SF344	MYOSIN-7
P04393	Ras Pathway	P04541	p90RSK	MOUSE|MGI=MGI=104557|UniProtKB=P18654	Ribosomal protein S6 kinase alpha-3	IDA	10480933	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	RAT|RGD=621029|UniProtKB=Q924U0	Leukotriene B4 receptor 2	ISS	10048442	gi	PTHR24230:SF8	LEUKOTRIENE B4 RECEPTOR 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00046	Oxidative stress response	P01129	JNK1/2	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00012	Cadherin signaling pathway	P00473	P120	MOUSE|MGI=MGI=1195966|UniProtKB=O35927	Catenin delta-2	ISS			PTHR10372:SF9	CATENIN DELTA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	CHICK|Ensembl=ENSGALG00000005139|UniProtKB=F1NW23	Clathrin heavy chain	IDA	9388255	PubMed	PTHR10292:SF7	CLATHRIN HEAVY CHAIN 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	IC	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00048	PI3 kinase pathway	P01181	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00052	TGF-beta signaling pathway	P01275	P38	DROME|FlyBase=FBgn0024846|UniProtKB=O61443	Mitogen-activated protein kinase 14B	TAS	10514528	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P04393	Ras Pathway	P04546	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00256	PLC-gamma	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	RCA	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00037	Ionotropic glutamate receptor pathway	P01023	CaMKII	PANTR|Ensembl=ENSPTRG00000017414|UniProtKB=H2QRT0	Uncharacterized protein	ISS	12888804	PubMed	PTHR43940:SF5	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	MOUSE|MGI=MGI=1351342|UniProtKB=Q3UVX5	Metabotropic glutamate receptor 5	ISS	92317054	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00036	Interleukin signaling pathway	P00973	PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEEL|WormBase=WBGene00018620|UniProtKB=O44588	Uncharacterized protein	ISS	3755548	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P02725	Allantoin degradation	P02818	Ureidoglycolate hydrolase	ECOLI|EcoGene=EG13615|UniProtKB=P77731	Ureidoglycolate lyase	ISS			PTHR21221:SF2	UREIDOGLYCOLATE LYASE
P02731	Biotin biosynthesis	P02859	Dethiobiotin synthase	AQUAE|EnsemblGenome=aq_557|UniProtKB=O66832	ATP-dependent dethiobiotin synthetase BioD	ISS			PTHR43210:SF2	DETHIOBIOTIN SYNTHETASE
P00029	Huntington disease	P00786	ARF	PANTR|Ensembl=ENSPTRG00000015051|UniProtKB=H2QMU4	ADP-ribosylation factor 4	ISS	12932731	PubMed	PTHR11711:SF110	ADP-RIBOSYLATION FACTOR 4
P06959	CCKR signaling map	P07163	SRC @Galphaq	HUMAN|HGNC=11283|UniProtKB=P12931	Proto-oncogene tyrosine-protein kinase Src	RCA	16874861	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00012	Cadherin signaling pathway	P00471	Cadherin	MONDO|Ensembl=ENSMODG00000021410|UniProtKB=F7CBX9	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF91	CADHERIN-7
P05734	Synaptic vesicle trafficking	P05776	RIM1alpha/2alpha	HUMAN|HGNC=17282|UniProtKB=Q86UR5	Regulating synaptic membrane exocytosis protein 1	IDA	11343654	PubMed	PTHR12157:SF19	REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN 1
P00022	General transcription by RNA polymerase I	P00657	TBP	CANLF|Ensembl=ENSCAFG00000004119|UniProtKB=F1PQA5	Uncharacterized protein	ISS	11988536	PubMed	PTHR10126:SF20	TATA-BOX-BINDING PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	TAS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00807	Actin	DAPPU|EnsemblGenome=DAPPUDRAFT_228751|UniProtKB=E9HGF5	Cytoplasmatic actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CHICK|Ensembl=ENSGALG00000008898|UniProtKB=F1P2J9	Uncharacterized protein	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00056	VEGF signaling pathway	P01414	PLC-gamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CAEBR|Gene=CBG05896|UniProtKB=A8X1E0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF147	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	SCLS1|EnsemblGenome=SS1G_04652|UniProtKB=A7EH60	Beta tubulin	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00029	Huntington disease	P00778	NMDA receptor	MOUSE|MGI=MGI=95819|UniProtKB=P35438	Glutamate receptor ionotropic, NMDA 1	IDA	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00048	PI3 kinase pathway	P01177	P110ACT	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01312	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00001	Adrenaline and noradrenaline biosynthesis	P00068	amine translocator	MONDO|Ensembl=ENSMODG00000020492|UniProtKB=F7F542	Transporter	ISS	12719981	PubMed	PTHR11616:SF101	SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER B 0 AT2
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00590	IP3 R	DROME|FlyBase=FBgn0010051|UniProtKB=P29993	Inositol 1,4,5-trisphosphate receptor	ISS	4262086	gi	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	MACMU|Ensembl=ENSMMUG00000012422|UniProtKB=F7DJH4	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	ANOGA|EnsemblGenome=AGAP005569|UniProtKB=Q7Q707	AGAP005569-PA	ISS	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00053	T cell activation	P01322	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01456	beta-arrestin	ANOGA|EnsemblGenome=AGAP006263|UniProtKB=Q7Q5Q8	AGAP006263-PA	IC	11742073	PubMed	PTHR11792:SF23	PHOSRESTIN-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00034	Integrin signalling pathway	P00947	Laminin	HUMAN|HGNC=6494|UniProtKB=Q9Y6N6	Laminin subunit gamma-3	IPI	2538453	PubMed	PTHR10574:SF240	LAMININ SUBUNIT GAMMA-3
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	BACSU|EnsemblGenome=BSU28080|UniProtKB=Q05865	Folylpolyglutamate synthase	ISS			PTHR11136:SF0	DIHYDROFOLATE SYNTHETASE-RELATED
P00047	PDGF signaling pathway	P01160	IP3 receptor	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	NEUCR|EnsemblGenome=EFNCRG00000004240|UniProtKB=Q01386	cAMP-dependent protein kinase regulatory subunit	IC	97076137	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00049	Parkinson disease	P01212	p38 MAPK	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MACMU|Ensembl=ENSMMUG00000001353|UniProtKB=F7D6T8	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00010	B cell activation	P00383	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00048	PI3 kinase pathway	P01179	PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02769	Purine metabolism	P03119	5'-Nucleotidase	MOUSE|MGI=MGI=99782|UniProtKB=Q61503	5'-nucleotidase	IDA	8224905	PubMed	PTHR11575:SF25	5'-NUCLEOTIDASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00702	CPB	MOUSE|MGI=MGI=88495|UniProtKB=P27699	cAMP-responsive element modulator	ISS			PTHR22952:SF97	CAMP-RESPONSIVE ELEMENT MODULATOR
P00018	EGF receptor signaling pathway	P00562	p38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IGI	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00006	Apoptosis signaling pathway	P00310	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00828	Galphai	NEUCR|EnsemblGenome=EFNCRG00000006213|UniProtKB=Q05425	Guanine nucleotide-binding protein alpha-1 subunit	ISS			PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00046	Oxidative stress response	P01129	JNK1/2	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CANLF|Ensembl=ENSCAFG00000015662|UniProtKB=E2RHY4	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MACMU|Ensembl=ENSMMUG00000015705|UniProtKB=F6SM00	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00006	Apoptosis signaling pathway	P00286	AIF	HUMAN|HGNC=8768|UniProtKB=O95831	Apoptosis-inducing factor 1, mitochondrial	IDA	9989411	PubMed	PTHR43557:SF4	APOPTOSIS-INDUCING FACTOR 1, MITOCHONDRIAL
P06664	Gonadotropin-releasing hormone receptor pathway	P06782	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	RCA	2372396	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01145	c-fos	BOVIN|Ensembl=ENSBTAG00000012777|UniProtKB=E1BJP4	Uncharacterized protein	ISS			PTHR11945:SF221	SERUM RESPONSE FACTOR
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	YEAST|SGD=S000003563|UniProtKB=P09938	Ribonucleoside-diphosphate reductase small chain 1	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00020	FAS signaling pathway	P00600	PARP	DROME|FlyBase=FBgn0010247|UniProtKB=P35875	Poly [ADP-ribose] polymerase	TAS	12101391	PubMed	PTHR10459:SF80	POLY  ADP-RIBOSE  POLYMERASE 1
P05912	Dopamine receptor mediated signaling pathway	P05959	FLNA	CANLF|Ensembl=ENSCAFG00000019521|UniProtKB=F1PWW0	Uncharacterized protein	ISS	11911837	PubMed	PTHR43998:SF6	FILAMIN-A
P02741	Flavin biosynthesis	P02936	FAD synthetase	PANTR|Ensembl=ENSPTRG00000001399|UniProtKB=H2Q060	FAD1 flavin adenine dinucleotide synthetase homolog	RCA			PTHR23293:SF9	FAD SYNTHASE
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8971|UniProtKB=O00443	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00928	alpha actinin	CAEBR|Gene=CBG23504|UniProtKB=A8Y3R8	Protein CBR-ATN-1	ISS	2116421	PubMed	PTHR43947:SF1	ALPHA-ACTININ, SARCOMERIC
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT1G18150|UniProtKB=Q9LM33	Mitogen-activated protein kinase 8	ISS	10514528	PubMed	PTHR24055:SF246	MITOGEN-ACTIVATED PROTEIN KINASE 15-RELATED
P04398	p53 pathway feedback loops 2	P04665	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	CHLRE|EnsemblGenome=CHLREDRAFT_189320|UniProtKB=A8ISA9	Cysteine synthase	ISS			PTHR10314:SF131	CYSTEINE SYNTHASE 1
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	IDA	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00018	EGF receptor signaling pathway	P00565	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00047	PDGF signaling pathway	P01142	p90RSK	XENTR|Xenbase=XB-GENE-480947|UniProtKB=F6ZM17	Uncharacterized protein (Fragment)	ISS	10558991	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00562	p38	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	IGI	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00030	Hypoxia response via HIF activation	P00824	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	TAS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00148	Erb-B4 N-terminal fragment	CHICK|Ensembl=ENSGALG00000003126|UniProtKB=F1P258	Receptor protein-tyrosine kinase	ISS	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	CANLF|Ensembl=ENSCAFG00000002046|UniProtKB=E2RBE7	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P00010	B cell activation	P00398	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IGI	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	HUMAN|HGNC=4403|UniProtKB=P61952	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	RCA	2122451	PubMed	PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P00057	Wnt signaling pathway	P01440	Cadherin	BOVIN|Ensembl=ENSBTAG00000019340|UniProtKB=F1MMW5	Uncharacterized protein	ISS	8120095	PubMed	PTHR43912:SF5	PROTOCADHERIN-9
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	ANOGA|EnsemblGenome=AGAP001506|UniProtKB=Q7PXP3	AGAP001506-PA	IC			PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00048	PI3 kinase pathway	P01189	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00049	Parkinson disease	P01230	Src kinase	DROME|FlyBase=FBgn0262733|UniProtKB=P00528	Tyrosine-protein kinase Src64B	IDA	8054685	PubMed	PTHR24418:SF283	TYROSINE-PROTEIN KINASE SRC64B
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CANLF|Ensembl=ENSCAFG00000002046|UniProtKB=E2RBE7	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P00019	Endothelin signaling pathway	P00572	MEK	CAEEL|WormBase=WBGene00003186|UniProtKB=Q10664	Dual specificity mitogen-activated protein kinase kinase mek-2	IGI	22022015	PubMed	PTHR24361:SF629	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=88396|UniProtKB=P12657	Muscarinic acetylcholine receptor M1	IDA			PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00049	Parkinson disease	P01211	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	DANRE|ZFIN=ZDB-GENE-030219-206|UniProtKB=Q5RGV1	Inosine-5'-monophosphate dehydrogenase 1b	ISS			PTHR11911:SF119	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 1B
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	TAS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	RCA	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	RAT|RGD=1307994|UniProtKB=B6RK61	Myosin heavy chain 7B	ISS	89264452	PubMed	PTHR13140:SF358	MYOSIN-7B
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	11956331	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00029	Huntington disease	P00807	Actin	PANTR|Ensembl=ENSPTRG00000002086|UniProtKB=H2Q1A9	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MONDO|Ensembl=ENSMODG00000008463|UniProtKB=F7GET1	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF196	REGULATOR OF G-PROTEIN SIGNALING 17
P00005	Angiogenesis	P00219	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00029	Huntington disease	P00805	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	ARATH|TAIR=AT5G16830|UniProtKB=Q39233	Syntaxin-21	IC			PTHR19957:SF38	T-SNARE DOMAIN-CONTAINING PROTEIN 1
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	CANLF|Ensembl=ENSCAFG00000005766|UniProtKB=F1PNW4	Uncharacterized protein	ISS	SYT1_BOVIN	SPACC	PTHR10024:SF239	SYNAPTOTAGMIN-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	CANLF|Ensembl=ENSCAFG00000018170|UniProtKB=E2RPM8	Tyrosine-protein kinase receptor	ISS	11182407	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	XENTR|Xenbase=XB-GENE-481916|UniProtKB=F6YF14	Presenilin	ISS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	RCA	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00025	Hedgehog signaling pathway	P00682	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P02748	Isoleucine biosynthesis	P02997	Acetolactate synthase	MYCTU|EnsemblGenome=Rv3003c|UniProtKB=P9WG41	Acetolactate synthase large subunit IlvB1	ISS			PTHR18968:SF116	ACETOLACTATE SYNTHASE ISOZYME 3 LARGE SUBUNIT
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	XENTR|Xenbase=XB-GENE-945015|UniProtKB=F6QA46	Uncharacterized protein	ISS	11752053	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	RAT|RGD=1303282|UniProtKB=Q6MG89	Notch homolog 4, [Drosophila]	ISS	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00011	Blood coagulation	P00433	uPAR	HUMAN|HGNC=9053|UniProtKB=Q03405	Urokinase plasminogen activator surface receptor	ISS	4505865	gi	PTHR10624:SF6	UROKINASE PLASMINOGEN ACTIVATOR SURFACE RECEPTOR
P04393	Ras Pathway	P04572	JNK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	ISS	11007936	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000001067|UniProtKB=E1BAB4	Uncharacterized protein	ISS	20012997	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00057	Wnt signaling pathway	P01471	alpha-catenin	HUMAN|HGNC=2510|UniProtKB=P26232	Catenin alpha-2	IDA	9362521	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	MACMU|Ensembl=ENSMMUG00000003962|UniProtKB=F6Z9D7	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	ARATH|TAIR=AT1G67220|UniProtKB=Q9FYH1	Histone acetyltransferase HAC2	IDA			PTHR13808:SF6	HISTONE ACETYLTRANSFERASE HAC2
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	HUMAN|HGNC=4586|UniProtKB=Q13224	Glutamate receptor ionotropic, NMDA 2B	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MOUSE|MGI=MGI=1340026|UniProtKB=P33435	Collagenase 3	TAS	1383028	PubMed	PTHR10201:SF165	COLLAGENASE 3
P00045	Notch signaling pathway	P01117	Neuralized	RAT|RGD=1308056|UniProtKB=D4A198	G protein pathway suppressor 2 (Predicted)	RCA			PTHR12429:SF14	NEURALIZED-LIKE PROTEIN 4
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=98958|UniProtKB=P22725	Protein Wnt-5a	IDA	8717036	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00021	FGF signaling pathway	P00624	14-3-3	RAT|RGD=3979|UniProtKB=P68255	14-3-3 protein theta	ISS	9211421	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P05915	Opioid proenkephalin pathway	P05992	met-Enkephalin	PANTR|Ensembl=ENSPTRG00000020270|UniProtKB=H2QW70	Proenkephalin	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05913	Enkephalin release	P05973	GPCR (i)	HUMAN|HGNC=8153|UniProtKB=P41143	Delta-type opioid receptor	ISS	11259487	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P02769	Purine metabolism	P03119	5'-Nucleotidase	HUMAN|HGNC=8021|UniProtKB=P21589	5'-nucleotidase	NAS	8224905	PubMed	PTHR11575:SF25	5'-NUCLEOTIDASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IDA	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00539	14-3-3	MACMU|Ensembl=ENSMMUG00000006489|UniProtKB=F7EFF6	14-3-3 protein zeta/delta	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00047	PDGF signaling pathway	P01142	p90RSK	CHICK|Gene_ORFName=RCJMB04_14g1|UniProtKB=Q5F3L1	Ribosomal protein S6 kinase alpha-5	ISS	9687510	PubMed	PTHR24351:SF115	RIBOSOMAL PROTEIN S6 KINASE ALPHA-5
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00021	FGF signaling pathway	P00642	MEK1-2	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	2574500	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00029	Huntington disease	P00778	NMDA receptor	CHICK|Ensembl=ENSGALG00000011809|UniProtKB=F1NMB0	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P02738	De novo purine biosynthesis	P02891	GDP kinase	MOUSE|MGI=MGI=2449121|UniProtKB=Q9QXL8	Nucleoside diphosphate kinase 7	ISS			PTHR43109:SF2	NUCLEOSIDE DIPHOSPHATE KINASE 7
P05913	Enkephalin release	G06045	preproenkephalin	MOUSE|MGI=MGI=104629|UniProtKB=P22005	Proenkephalin-A	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04392	P53 pathway feedback loops 1	G04686	p73	HUMAN|HGNC=12003|UniProtKB=O15350	Tumor protein p73	ISS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	CHICK|Ensembl=ENSGALG00000011809|UniProtKB=F1NMB0	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IDA	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	9754712	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	RAT|RGD=2733|UniProtKB=P42260	Glutamate receptor ionotropic, kainate 2	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00048	PI3 kinase pathway	P01199	Galpha	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	IC	1333286	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	BRAFL|Gene=BRAFLDRAFT_215305|UniProtKB=C3YPV2	Putative uncharacterized protein (Fragment)	ISS	5031595	gi	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00942	Fyn	XENTR|Xenbase=XB-GENE-6053489|UniProtKB=F6S8L5	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000005862|UniProtKB=F1PL99	Phosphoinositide phospholipase C	ISS			PTHR10336:SF84	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	MACMU|Ensembl=ENSMMUG00000019817|UniProtKB=F7FY63	Protein-serine/threonine kinase	ISS	12032308	PubMed	PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	RAT|RGD=1303282|UniProtKB=Q6MG89	Notch homolog 4, [Drosophila]	ISS	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	MOUSE|MGI=MGI=109284|UniProtKB=Q61144	Presenilin-2	IDA	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00049	Parkinson disease	P01212	p38 MAPK	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	NAS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	11591316	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	DANRE|ZFIN=ZDB-GENE-030616-382|UniProtKB=B5LZ08	Protein-serine/threonine kinase	RCA			PTHR24355:SF18	PROTEIN-SERINE/THREONINE KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00048	PI3 kinase pathway	P01199	Galpha	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04494	TSC2	MACMU|Ensembl=ENSMMUG00000002808|UniProtKB=F7H034	Uncharacterized protein	ISS	12150915	PubMed	PTHR10063:SF0	TUBERIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00034	Integrin signalling pathway	P00912	Arp2/3	HUMAN|HGNC=706|UniProtKB=O15145	Actin-related protein 2/3 complex subunit 3	IPI	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00036	Interleukin signaling pathway	P00990	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IC	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00916	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P05731	GABA-B receptor II signaling	P05754	Ggamma	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04393	Ras Pathway	P04578	Rho	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	IDA	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P02728	Arginine biosynthesis	P02846	Ornithine carbamoyl transferase	XENTR|Xenbase=XB-GENE-982300|UniProtKB=F7BNT2	Uncharacterized protein	ISS			PTHR11405:SF1	ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	IDA	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000012036|UniProtKB=F7ALP1	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00048	PI3 kinase pathway	P01199	Galpha	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	RCA	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00019	Endothelin signaling pathway	P00591	PLCbeta	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00887	IRS 1-4	MACMU|Ensembl=ENSMMUG00000021790|UniProtKB=F7DE94	Uncharacterized protein	ISS	5031805	gi	PTHR10614:SF7	INSULIN RECEPTOR SUBSTRATE 2
P00021	FGF signaling pathway	P00643	Raf-1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IGI	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	11591316	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Ensembl=ENSPTRG00000011042|UniProtKB=H2QGF5	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CAEBR|Gene=CBG05896|UniProtKB=A8X1E0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF147	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-2
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IC	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CHICK|Ensembl=ENSGALG00000002098|UniProtKB=F1P0L4	Uncharacterized protein	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00760	Gtalpha	HUMAN|HGNC=4393|UniProtKB=P11488	Guanine nucleotide-binding protein G(t) subunit alpha-1	IDA	10188796	PubMed	PTHR10218:SF67	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-1
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00030	Hypoxia response via HIF activation	P00823	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2522|UniProtKB=P30729	D(4) dopamine receptor	IDA	2137198	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_127490|UniProtKB=C3XYC5	Putative uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	TAKRU|Ensembl=ENSTRUG00000003442|UniProtKB=H2S6Q5	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF197	CALMODULIN-LIKE PROTEIN 3
P00006	Apoptosis signaling pathway	P00321	HSP70	CANLF|Ensembl=ENSCAFG00000000639|UniProtKB=L7N050	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF210	HEAT SHOCK 70 KDA PROTEIN 1-LIKE
P00059	p53 pathway	P04616	PDK1/2	SCHPO|PomBase=SPCC576.15c|UniProtKB=Q12701	Serine/threonine-protein kinase ksg1	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00059	p53 pathway	G01565	PERP	RAT|RGD=1310294|UniProtKB=B2GVC0	PERP, TP53 apoptosis effector	ISS			PTHR14399:SF4	P53 APOPTOSIS EFFECTOR RELATED TO PMP-22
P00034	Integrin signalling pathway	P00928	alpha actinin	PANTR|Ensembl=ENSPTRG00000014354|UniProtKB=H2QLM8	Uncharacterized protein	ISS			PTHR44664:SF1	MICAL-LIKE PROTEIN 1
P00011	Blood coagulation	P00454	FVII	PANTR|Gene=F7|UniProtKB=Q2F9P2	Coagulation factor VII	ISS	4503645	gi	PTHR44064:SF1	COAGULATION FACTOR VII
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MONDO|Ensembl=ENSMODG00000020977|UniProtKB=F6S5B1	Uncharacterized protein (Fragment)	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	YEAST|SGD=S000001855|UniProtKB=P60010	Actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00010	B cell activation	P00398	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00839	SHIP	RAT|RGD=68396|UniProtKB=Q9WVR3	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	ISS	10381377	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00034	Integrin signalling pathway	P00923	Arf1	HUMAN|HGNC=652|UniProtKB=P84077	ADP-ribosylation factor 1	IPI	11752622	PubMed	PTHR11711:SF234	ADP-RIBOSYLATION FACTOR 1
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00182	p38MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00004	Alzheimer disease-presenilin pathway	P00114	actin	XENTR|Xenbase=XB-GENE-491618|UniProtKB=Q6P378	Actin, cytoplasmic 2	ISS	11889139	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02776	Serine glycine biosynthesis	P03157	Phosphoserine aminotransferase	ARATH|TAIR=AT2G17630|UniProtKB=Q9SHP0	Phosphoserine aminotransferase 2, chloroplastic	ISS			PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P05913	Enkephalin release	P05972	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05731	GABA-B receptor II signaling	P05755	Gbeta	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MACMU|Ensembl=ENSMMUG00000022347|UniProtKB=F6ZCH5	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00168	E-cadherin intracellular fragment	XENTR|Xenbase=XB-GENE-482277|UniProtKB=F6QAX3	Uncharacterized protein	ISS	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P00054	Toll receptor signaling pathway	P01360	IKKbeta	MACMU|Ensembl=ENSMMUG00000008351|UniProtKB=F7HRV5	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00048	PI3 kinase pathway	P01178	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	9763606	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	IC	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00049	Parkinson disease	P01211	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01167	Ets	ORNAN|Ensembl=ENSOANG00000012104|UniProtKB=F7FH70	Uncharacterized protein	ISS	3284179	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04578	Rho	CHICK|Ensembl=ENSGALG00000001569|UniProtKB=Q9PSX7	Rho-related GTP-binding protein RhoC	ISS	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00012	Cadherin signaling pathway	P00474	Wnt	TAKRU|Ensembl=ENSTRUG00000017138|UniProtKB=H2V3X9	Protein Wnt	IDA	11266476	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00048	PI3 kinase pathway	P01202	p85	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	IGI	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05730	Endogenous cannabinoid signaling	P05751	Galpha	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00547	PP2A	TAKRU|Ensembl=ENSTRUG00000014295|UniProtKB=H2UHY7	Serine/threonine-protein phosphatase	ISS			PTHR11668:SF24	SERINE/THREONINE-PROTEIN PHOSPHATASE 6 CATALYTIC SUBUNIT
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DANRE|ZFIN=ZDB-GENE-040426-2427|UniProtKB=F1Q6C0	Uncharacterized protein (Fragment)	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	RAT|RGD=1304559|UniProtKB=D4A3W9	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	CAEEL|WormBase=WBGene00020146|UniProtKB=Q22067	Probable aspartate aminotransferase, cytoplasmic	ISS			PTHR11879:SF22	ASPARTATE AMINOTRANSFERASE
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000017332|UniProtKB=Q5DRD1	Protocadherin beta-3	ISS	8120095	PubMed	PTHR24028:SF118	PROTOCADHERIN BETA-3
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	12805548	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MONDO|Ensembl=ENSMODG00000004422|UniProtKB=F6SCX2	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF344	MYOSIN-7
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	IDA	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00019	Endothelin signaling pathway	P00568	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	IGI	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	10891487	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00034	Integrin signalling pathway	P00916	Ras	CAEBR|Gene=CBG06092|UniProtKB=A8X0X5	Protein CBR-LET-60	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00005	Angiogenesis	P00212	EphR	MACMU|Ensembl=ENSMMUG00000003304|UniProtKB=F7ELA0	Uncharacterized protein	ISS	9990854	PubMed	PTHR24416:SF120	EPHRIN TYPE-B RECEPTOR 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	RAT|RGD=620027|UniProtKB=P08911	Muscarinic acetylcholine receptor M5	IDA	11166329	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BOVIN|Ensembl=ENSBTAG00000006189|UniProtKB=P63258	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	PANTR|Gene=CHRM2|UniProtKB=Q9N2A7	Muscarinic acetylcholine receptor M2 (Fragment)	ISS	91373358	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00018	EGF receptor signaling pathway	P00561	STAT	CANLF|Ensembl=ENSCAFG00000015346|UniProtKB=E2RE22	Signal transducer and activator of transcription	ISS	10835485	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	PANTR|Ensembl=ENSPTRG00000008026|UniProtKB=H2QAZ2	Syntaxin 1B	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00006	Apoptosis signaling pathway	P00260	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00269	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10557357	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00052	TGF-beta signaling pathway	P01276	Co-Smads	ANOGA|EnsemblGenome=AGAP002902|UniProtKB=Q7QD16	Mothers against decapentaplegic homolog	ISS			PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04392	P53 pathway feedback loops 1	P04537	p73DeltaN	PANTR|Ensembl=ENSPTRG00000015733|UniProtKB=H2QNY5	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	PANTR|Ensembl=ENSPTRG00000023608|UniProtKB=H2QZZ2	Uncharacterized protein	ISS	11319238	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00024	Glycolysis	P00679	Aldolase	PANTR|Gene=ALDOA|UniProtKB=A5A6I5	Fructose-bisphosphate aldolase A	ISS	3391172	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00005	Angiogenesis	P00221	JNK1	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-8225|UniProtKB=Q7SZZ5	Uncharacterized protein	ISS			PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00056	VEGF signaling pathway	P01413	PI3K	DROME|FlyBase=FBgn0015278|UniProtKB=Q7K3H0	LD28067p	ISS	8662856	PubMed	PTHR10048:SF64	LD28067P
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	CANLF|Ensembl=ENSCAFG00000013966|UniProtKB=F1PJF3	Uncharacterized protein	ISS			PTHR11405:SF38	CARBAMOYL-PHOSPHATE SYNTHASE  AMMONIA , MITOCHONDRIAL
P00029	Huntington disease	P00803	Sp1	BOVIN|Ensembl=ENSBTAG00000002604|UniProtKB=E1BMR6	Uncharacterized protein	ISS			PTHR23235:SF25	TRANSCRIPTION FACTOR SP8
P00057	Wnt signaling pathway	P01458	Protein Kinase C	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00049	Parkinson disease	P01238	14-3-3	MONDO|Ensembl=ENSMODG00000006158|UniProtKB=F7BS95	Uncharacterized protein	ISS	92283271	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00053	T cell activation	P01305	Calmodulin	MONDO|Ensembl=ENSMODG00000025146|UniProtKB=F7CLC0	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF311	CALMODULIN
P02746	Heme biosynthesis	P02982	Protoheme IX farnesyl transferase	STRCO|EnsemblGenome=CAB50759|UniProtKB=Q9XAC2	Protoheme IX farnesyltransferase	ISS			PTHR43448:SF2	PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL
P04393	Ras Pathway	P04546	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	IDA	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00049	Parkinson disease	P01238	14-3-3	BOVIN|Ensembl=ENSBTAG00000002108|UniProtKB=Q3SZI4	14-3-3 protein theta	ISS	5803227	gi	PTHR18860:SF3	14-3-3 PROTEIN THETA
P00019	Endothelin signaling pathway	P00580	ET-RA/B	PANTR|Ensembl=ENSPTRG00000016494|UniProtKB=H2QQ94	Endothelin receptor type A	ISS	12875994	PubMed	PTHR24243:SF31	ENDOTHELIN-1 RECEPTOR
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	RAT|RGD=1359152|UniProtKB=Q9QXY8	C-C motif chemokine 7	ISS			PTHR12015:SF78	C-C MOTIF CHEMOKINE 7
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00305	Caspase 3	MOUSE|MGI=MGI=107739|UniProtKB=P70677	Caspase-3	ISS	11675509	PubMed	PTHR10454:SF198	CASPASE-3
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	MONDO|Ensembl=ENSMODG00000014177|UniProtKB=F6U7A6	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IDA	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	MACMU|Ensembl=ENSMMUG00000010173|UniProtKB=F7AGU8	Presenilin	ISS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CAEBR|Gene=CBG02401|UniProtKB=A8WUE7	Protein CBR-NMR-1	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P02742	Tetrahydrofolate biosynthesis	P02951	GTP cyclohydrolase	CAEBR|Gene=CBG09642|UniProtKB=A8X8K8	Protein CBR-CAT-4	ISS			PTHR11109:SF0	GTP CYCLOHYDROLASE 1
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00182	p38MAPK	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IDA	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02747	Histidine biosynthesis	P02992	Imidazol glycerol phosphate synthase	ECOLI|EcoGene=EG10448|UniProtKB=P60664	Imidazole glycerol phosphate synthase subunit HisF	ISS			PTHR21235:SF2	IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	BOVIN|Ensembl=ENSBTAG00000016198|UniProtKB=E1B8D6	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00005	Angiogenesis	P00189	Fzd	PANTR|Ensembl=ENSPTRG00000020122|UniProtKB=H2QVZ0	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF22	FRIZZLED-3
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00001	Adrenaline and noradrenaline biosynthesis	P00067	MAO	DANRE|ZFIN=ZDB-GENE-040329-3|UniProtKB=Q6NSN2	Amine oxidase [flavin-containing]	ISS	90344230	PubMed	PTHR43563:SF2	AMINE OXIDASE  FLAVIN-CONTAINING
P00021	FGF signaling pathway	P00629	PP2A	MOUSE|MGI=MGI=2442660|UniProtKB=Q8BG02	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform	ISS	12191994	PubMed	PTHR11871:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B GAMMA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014555|UniProtKB=F7GT55	Syntaxin-1A isoform 1	ISS	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00006	Apoptosis signaling pathway	P00322	Cytochrome C	CAEEL|WormBase=WBGene00017121|UniProtKB=P19974	Cytochrome c 2.1	ISS			PTHR11961:SF12	CYTOCHROME C
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	IDA	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00052	TGF-beta signaling pathway	P01275	P38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	ISS	12805548	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	22533439	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00516	Ena/VASP	HUMAN|HGNC=12652|UniProtKB=P50552	Vasodilator-stimulated phosphoprotein	ISS	8836115	PubMed	PTHR11202:SF12	VASODILATOR-STIMULATED PHOSPHOPROTEIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MOUSE|MGI=MGI=894282|UniProtKB=O08858	Somatostatin receptor type 5	IDA			PTHR24229:SF20	SOMATOSTATIN RECEPTOR TYPE 5
P00059	p53 pathway	P01485	p53	CHICK|Ensembl=ENSGALG00000007324|UniProtKB=F1N8Z7	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	DROME|FlyBase=FBgn0004103|UniProtKB=P12982	Serine/threonine-protein phosphatase alpha-2 isoform	ISS	8392016	PubMed	PTHR11668:SF402	SERINE/THREONINE-PROTEIN PHOSPHATASE
P04393	Ras Pathway	P04557	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00006	Apoptosis signaling pathway	P00298	Caspase 9	MACMU|Ensembl=ENSMMUG00000018163|UniProtKB=F7FNC1	Caspase	ISS	11440972	PubMed	PTHR10454:SF157	CASPASE-9
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	IDA	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00020	FAS signaling pathway	P00615	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00049	Parkinson disease	P01208	Hsp70	BACSU|EnsemblGenome=BSU25470|UniProtKB=P17820	Chaperone protein DnaK	IDA	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P00035	Interferon-gamma signaling pathway	P00952	Jak2	MOUSE|MGI=MGI=96629|UniProtKB=Q62120	Tyrosine-protein kinase JAK2	TAS	12686512	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P04396	Vitamin D metabolism and pathway	P04607	FDX	GIAIC|EnsemblGenome=GL50803_27266|UniProtKB=E2RU02	[2Fe-2S] ferredoxin	ISS			PTHR23426:SF25	FERREDOXIN 2
P06587	Nicotine pharmacodynamics pathway	P06594	CHRNA4	PANTR|Gene=CHRNA4|UniProtKB=Q5IS77	Neuronal acetylcholine receptor subunit alpha-4	ISS	85270494	PubMed	PTHR18945:SF401	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4
P00006	Apoptosis signaling pathway	P00310	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IDA	96009592	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00036	Interleukin signaling pathway	P00964	p90RSK	CANLF|Ensembl=ENSCAFG00000000828|UniProtKB=F6UWI0	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00059	p53 pathway	P04609	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	PSEAE|EnsemblGenome=PA0932|UniProtKB=Q9I526	Cysteine synthase B	ISS			PTHR10314:SF100	CYSTEINE SYNTHASE B
P00010	B cell activation	P00381	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	3449797	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ENTHI|EnsemblGenome=EHI_107290|UniProtKB=B1N2P0	Actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00048	PI3 kinase pathway	P01185	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00219	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00034	Integrin signalling pathway	P00938	Cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000008503|UniProtKB=F6TGJ6	Uncharacterized protein	ISS	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00877	MLCK	RAT|RGD=620934|UniProtKB=P20689	Myosin light chain kinase 2, skeletal/cardiac muscle	IDA	600922	OMIM	PTHR45210:SF1	MYOSIN LIGHT CHAIN KINASE 2, SKELETAL/CARDIAC MUSCLE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	RCA	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	PANTR|Gene=CXCR1|UniProtKB=P55920	C-X-C chemokine receptor type 1	ISS	1840701	PubMed	PTHR10489:SF916	C-X-C CHEMOKINE RECEPTOR TYPE 1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	DANRE|ZFIN=ZDB-GENE-990415-279|UniProtKB=P51029	Protein Wnt-8b	TAS	11266476	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00018	EGF receptor signaling pathway	P00539	14-3-3	CAEBR|Gene=CBG06174|UniProtKB=A8X0R4	Protein CBR-PAR-5	ISS	10407019	PubMed	PTHR18860:SF21	14-3-3-LIKE PROTEIN 1
P00047	PDGF signaling pathway	P01143	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	21186066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P02746	Heme biosynthesis	P02979	porphobilinogen synthase	ARATH|TAIR=AT1G44318|UniProtKB=Q94LA4	Probable delta-aminolevulinic acid dehydratase 2, chloroplastic	ISS			PTHR11458:SF0	DELTA-AMINOLEVULINIC ACID DEHYDRATASE
P00029	Huntington disease	P00775	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00010	B cell activation	P00373	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IGI	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02920	dCTP deaminase	BACSU|EnsemblGenome=BSU13170|UniProtKB=O34598	Guanine deaminase	ISS			PTHR44192:SF2	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CAEEL|WormBase=WBGene00010545|UniProtKB=G5EBG3	CBP/p300 homolog	TAS	10664585	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00053	T cell activation	P01324	rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	15470041	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00057	Wnt signaling pathway	P01444	Wnt	DANRE|ZFIN=ZDB-GENE-980526-416|UniProtKB=Q92048	Protein Wnt-2	IDA	8717036	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	HUMAN|HGNC=11773|UniProtKB=P37173	TGF-beta receptor type-2	TAS	9759503	PubMed	PTHR23255:SF55	TGF-BETA RECEPTOR TYPE-2
P00018	EGF receptor signaling pathway	P00557	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IGI	7565716	PubMed	PTHR10048:SF14	PI-3 KINASE
P00029	Huntington disease	G01532	PolyQ HTT	CANLF|Ensembl=ENSCAFG00000014682|UniProtKB=F1P7Y7	Uncharacterized protein	ISS	7620118	PubMed	PTHR10170:SF10	HUNTINGTIN
P00057	Wnt signaling pathway	P01435	SWI/SNF	RAT|RGD=1302988|UniProtKB=E9PTG1	Protein Smarca2	ISS	11532957	PubMed	PTHR10799:SF541	GLOBAL TRANSCRIPTION ACTIVATOR SNF2L2-RELATED
P00006	Apoptosis signaling pathway	P00269	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	8170357	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IDA	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	XENTR|Xenbase=XB-GENE-483455|UniProtKB=Q0IHM5	Receptor protein serine/threonine kinase	ISS	10683140	PubMed	PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	TAS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00906	Rap1	MACMU|Ensembl=ENSMMUG00000022747|UniProtKB=F7GCR4	Ras-related protein Rap-2a	ISS	8576107	PubMed	PTHR24070:SF221	RAS-RELATED PROTEIN RAP-2A
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	SCHMA|EnsemblGenome=Smp_020170|UniProtKB=G4V8E3	Voltage-dependent calcium channel (Fragment)	ISS	14507926	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00010	B cell activation	P00373	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IGI	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MONDO|Ensembl=ENSMODG00000020977|UniProtKB=F6S5B1	Uncharacterized protein (Fragment)	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00004	Alzheimer disease-presenilin pathway	P00127	APP	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	RCA	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04393	Ras Pathway	P04572	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00111	C99	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P06664	Gonadotropin-releasing hormone receptor pathway	P06849	Sos	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	RCA	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05918	p38 MAPK pathway	P06020	p38delta	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	RCA	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	RAT|RGD=3852|UniProtKB=P80204	TGF-beta receptor type-1	TAS	9395284	PubMed	PTHR23255:SF61	TGF-BETA RECEPTOR TYPE-1
P05915	Opioid proenkephalin pathway	P05994	G-protein	YEAST|SGD=S000005738|UniProtKB=P18851	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00019	Endothelin signaling pathway	P00586	Gq	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04580	TRH Receptor	MONDO|Ensembl=ENSMODG00000004935|UniProtKB=F7AUF1	Uncharacterized protein	ISS	7509436	PubMed	PTHR24243:SF115	THYROTROPIN-RELEASING HORMONE RECEPTOR
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	ECOLI|EcoGene=EG10589|UniProtKB=P0A817	S-adenosylmethionine synthase	ISS			PTHR11964:SF1	S-ADENOSYLMETHIONINE SYNTHASE
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00052	TGF-beta signaling pathway	P01284	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	HUMAN|HGNC=7571|UniProtKB=Q9UKX3	Myosin-13	ISS	89264452	PubMed	PTHR13140:SF504	MYOSIN-13
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	MOUSE|MGI=MGI=2155865|UniProtKB=Q6PEE3	Ribonucleoside-diphosphate reductase subunit M2 B	ISS			PTHR23409:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 B
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00057	Wnt signaling pathway	P01439	C-terminal Binding Protein	MOUSE|MGI=MGI=1201685|UniProtKB=O88712	C-terminal-binding protein 1	IDA	10375506	PubMed	PTHR10996:SF128	C-TERMINAL-BINDING PROTEIN 1
P00005	Angiogenesis	P00193	SOS-1	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00052	TGF-beta signaling pathway	P01275	P38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	TAS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00029	Huntington disease	P00795	BDNF	PANTR|Ensembl=ENSPTRG00000028696|UniProtKB=Q5IS78	Brain-derived neurotrophic factor	ISS	11408619	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00005	Angiogenesis	P00219	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00203	Erk	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	HUMAN|HGNC=1403|UniProtKB=P54284	Voltage-dependent L-type calcium channel subunit beta-3	IC			PTHR11824:SF8	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-3
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	STRPU|EnsemblGenome=SPU_003166|UniProtKB=W4XIE2	Uncharacterized protein	IEP	11274345	PubMed	PTHR11514:SF95	MYC PROTEIN
P00023	General transcription regulation	P00663	TFIIFalpha	BOVIN|Ensembl=ENSBTAG00000021016|UniProtKB=Q5EA53	General transcription factor IIF subunit 1	ISS	12732728	PubMed	PTHR13011:SF0	GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	15737619	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00019	Endothelin signaling pathway	P00572	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	MONDO|Ensembl=ENSMODG00000015970|UniProtKB=F7FD05	Uncharacterized protein	ISS	14604761	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00012	Cadherin signaling pathway	P00471	Cadherin	CANLF|Ensembl=ENSCAFG00000006229|UniProtKB=E2QX93	Uncharacterized protein	ISS	8120095	PubMed	PTHR43912:SF3	PROTOCADHERIN-1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00006	Apoptosis signaling pathway	P00272	ASK1	HUMAN|HGNC=6857|UniProtKB=Q99683	Mitogen-activated protein kinase kinase kinase 5	IDA	11730323	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	BACTN|EnsemblGenome=BT_4339|UniProtKB=Q89ZN8	Glutamine synthetase	ISS			PTHR42974:SF1	TYPE-3 GLUTAMINE SYNTHETASE
P00023	General transcription regulation	P00661	TTF2	MACMU|Ensembl=ENSMMUG00000022278|UniProtKB=F6XFN3	Uncharacterized protein	ISS	604718	OMIM	PTHR15437:SF1	TRANSCRIPTION TERMINATION FACTOR 2, MITOCHONDRIAL
P00048	PI3 kinase pathway	P01185	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04397	p53 pathway by glucose deprivation	P04639	AMPK	MACMU|Ensembl=ENSMMUG00000010406|UniProtKB=F7D386	Uncharacterized protein	ISS			PTHR24343:SF303	5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-2
P00009	Axon guidance mediated by netrin	P00363	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00023	General transcription regulation	P00662	TFIIA complex	SCHPO|PomBase=SPBC28F2.09|UniProtKB=Q9USU9	Transcription initiation factor IIA large subunit	ISS	600519	OMIM	PTHR12694:SF8	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04393	Ras Pathway	P04578	Rho	TAKRU|Ensembl=ENSTRUG00000011944|UniProtKB=H2TZX5	Uncharacterized protein	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	PANTR|Ensembl=ENSPTRG00000012660|UniProtKB=H2QJ07	Activating transcription factor 2	ISS	10664585	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	MACMU|Ensembl=ENSMMUG00000000163|UniProtKB=F7HLV0	Uncharacterized protein	ISS	15155845	PubMed	PTHR18945:SF82	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-6
P00056	VEGF signaling pathway	P01420	FAK	DANRE|ZFIN=ZDB-GENE-020114-1|UniProtKB=F1QT14	Uncharacterized protein	ISS	12640026	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00056	VEGF signaling pathway	P01425	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05915	Opioid proenkephalin pathway	P05988	peptide E	PANTR|Ensembl=ENSPTRG00000020270|UniProtKB=H2QW70	Proenkephalin	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00021	FGF signaling pathway	P00632	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000018563|UniProtKB=F6YMF6	Uncharacterized protein	ISS	12562507	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P00019	Endothelin signaling pathway	P00582	COX-2	MACMU|Ensembl=ENSMMUG00000016857|UniProtKB=F7BWZ9	Uncharacterized protein	ISS	12871860	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=4404|UniProtKB=P59768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00047	PDGF signaling pathway	P01142	p90RSK	PANTR|Ensembl=ENSPTRG00000009477|UniProtKB=H2QDK7	Ribosomal protein S6 kinase	ISS	11861821	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00846	JAK	MACMU|Ensembl=ENSMMUG00000014558|UniProtKB=F7GT47	Tyrosine-protein kinase	ISS	22482294	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02751	Lysine biosynthesis	P03011	N-succinyldiaminopimelate  aminotransferase	STRCO|EnsemblGenome=CAB76097|UniProtKB=Q9L1A4	Acetylornithine aminotransferase	IDA			PTHR11986:SF79	ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL
P05918	p38 MAPK pathway	P06029	p38beta	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	RCA	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00056	VEGF signaling pathway	P01407	Erk	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000005917|UniProtKB=F6QM53	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DROME|FlyBase=FBgn0000045|UniProtKB=P02574	Actin, larval muscle	IDA	14684598	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CANLF|Gene=GRIN1|UniProtKB=Q5R1P0	Glutamate receptor ionotropic, NMDA 1	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00054	Toll receptor signaling pathway	P01356	ERK2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9836512	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01238	14-3-3	PANTR|Ensembl=ENSPTRG00000011641|UniProtKB=H2QHF1	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	ISS	5803227	gi	PTHR18860:SF3	14-3-3 PROTEIN THETA
P00019	Endothelin signaling pathway	P00567	PKG	BOVIN|Ensembl=ENSBTAG00000018404|UniProtKB=P00516	cGMP-dependent protein kinase 1	IGI	9099696	PubMed	PTHR24353:SF68	SUBFAMILY NOT NAMED
P00010	B cell activation	P00375	Calmodulin	MONDO|Ensembl=ENSMODG00000004410|UniProtKB=F6SV58	Uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF322	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00591	PLCbeta	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IGI	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00006	Apoptosis signaling pathway	P00260	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00709	Glycogen synthase D	CANLF|Ensembl=ENSCAFG00000025047|UniProtKB=F1PR30	Uncharacterized protein	ISS	4212312	PubMed	PTHR10176:SF1	GLYCOGEN  STARCH  SYNTHASE, LIVER
P00046	Oxidative stress response	P01129	JNK1/2	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00053	T cell activation	P01300	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9836512	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	RAT|RGD=621276|UniProtKB=O35119	Short transient receptor potential channel 4	IDA	11055438	PubMed	PTHR10117:SF25	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 4
P00057	Wnt signaling pathway	P01465	Ggamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IDA	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=109355|UniProtKB=O35526	Syntaxin-1A	ISS	1321498	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000000289|UniProtKB=F7A9T0	Uncharacterized protein	ISS	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000000843|UniProtKB=H2QZN8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00056	VEGF signaling pathway	P01425	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014555|UniProtKB=F7GT55	Syntaxin-1A isoform 1	ISS	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00023	General transcription regulation	P00658	TBP-associated factors	CHICK|Ensembl=ENSGALG00000000991|UniProtKB=Q5ZKX3	Uncharacterized protein	ISS			PTHR12264:SF21	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12
P00034	Integrin signalling pathway	P00916	Ras	CHICK|Ensembl=ENSGALG00000014033|UniProtKB=E1BTS2	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P05917	Opioid proopiomelanocortin pathway	P06011	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	RAT|RGD=1359278|UniProtKB=Q5UEM7	Cyclic AMP-responsive element-binding protein 3-like protein 4	ISS	608972	OMIM	PTHR22952:SF105	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 4
P02783	Tryptophan biosynthesis	P03209	Anthranilate phosphoribosyl transferase	ARATH|TAIR=AT1G70570|UniProtKB=F4I5H7	Putative anthranilate phosphoribosyltransferase	ISS			PTHR11922:SF1	ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	NEMVE|Gene=v1g118944|UniProtKB=A7SHY4	Predicted protein (Fragment)	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00012	Cadherin signaling pathway	P00464	Fyn	BOVIN|Ensembl=ENSBTAG00000011851|UniProtKB=A0JNB0	Tyrosine-protein kinase Fyn	ISS	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00005	Angiogenesis	P00192	PAR	BOVIN|Gene=F2R|UniProtKB=A7YY44	Proteinase-activated receptor 1	RCA			PTHR24232:SF20	PROTEINASE-ACTIVATED RECEPTOR 1
P00054	Toll receptor signaling pathway	P01368	MKK2	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P06664	Gonadotropin-releasing hormone receptor pathway	P06847	JNK1/2	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	RCA	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00048	PI3 kinase pathway	P01182	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00048	PI3 kinase pathway	P01202	p85	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	IC	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00833	RGS	MOUSE|MGI=MGI=1927469|UniProtKB=Q9QZB0	Regulator of G-protein signaling 17	IDA	8756726	PubMed	PTHR10845:SF196	REGULATOR OF G-PROTEIN SIGNALING 17
P00019	Endothelin signaling pathway	P00586	Gq	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00010	B cell activation	P00369	MEKK	PANTR|Ensembl=ENSPTRG00000009518|UniProtKB=H2QDN0	Mitogen-activated protein kinase kinase kinase 3	ISS	11730323	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P04393	Ras Pathway	P04547	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	TAS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00828	Galphai	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	RCA			PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	FUSNN|EnsemblGenome=FN0103|UniProtKB=Q8RH17	Ribonucleoside-diphosphate reductase subunit beta	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00049	Parkinson disease	P01242	Casein kinase I	ORYSJ|Gene=Os01g0198200|UniProtKB=Q5QMY9	Os01g0198200 protein	IDA	11437445	PubMed	PTHR11909:SF288	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01407	Erk	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00774	Dynein complex	EMENI|EnsemblGenome=CADANIAG00002629|UniProtKB=P45444	Dynein heavy chain, cytoplasmic	IPI	9454836	PubMed	PTHR10676:SF314	CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	4757952	gi	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00048	PI3 kinase pathway	P01179	PKB	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	4506785	gi	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00036	Interleukin signaling pathway	P00996	STAT	HUMAN|HGNC=11364|UniProtKB=P40763	Signal transducer and activator of transcription 3	IC	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00019	Endothelin signaling pathway	P00586	Gq	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IGI	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00570	PKA	LEPIN|EnsemblGenome=LA_1929|UniProtKB=Q8CXT1	CAP family transcription factor	ISS	88234494	PubMed	PTHR45452:SF1	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	SCHPO|PomBase=SPBC14C8.06|UniProtKB=P78774	Actin-related protein 2/3 complex subunit 1	ISS	12963527	gi	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DANRE|ZFIN=ZDB-GENE-030131-172|UniProtKB=Q6IQR3	Actin, alpha, cardiac muscle 1a	IEP	10974003	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	CANAL|CGD=CAL0005264|UniProtKB=Q5ACW5	Casein kinase II subunit beta	IDA	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P04395	Vasopressin synthesis	P04593	Glycopeptide	BOVIN|Ensembl=ENSBTAG00000008026|UniProtKB=P01175	Oxytocin-neurophysin 1	IC	1706187	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	CANLF|Ensembl=ENSCAFG00000019275|UniProtKB=E2QY91	Uncharacterized protein	ISS	12549854	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05915	Opioid proenkephalin pathway	P05994	G-protein	PANTR|Ensembl=ENSPTRG00000007084|UniProtKB=H2Q9G5	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BOVIN|Ensembl=ENSBTAG00000002664|UniProtKB=F1N7G3	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF84	PROTEIN WNT-9B
P00015	Circadian clock system	P00502	Casein kinase I	DANRE|ZFIN=ZDB-GENE-040426-2385|UniProtKB=Q6P3K7	Casein kinase I isoform delta-B	ISS	10617630	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00005	Angiogenesis	P00227	PLA2	BOVIN|Ensembl=ENSBTAG00000013298|UniProtKB=A4IFJ5	Cytosolic phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	MACMU|Ensembl=ENSMMUG00000009009|UniProtKB=F7H249	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF63	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-2
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IC	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00047	PDGF signaling pathway	P01162	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00019	Endothelin signaling pathway	P00590	IP3 R	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	IGI	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	MOUSE|MGI=MGI=109482|UniProtKB=P97445	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	15699344	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	ENTHI|EnsemblGenome=EHI_042140|UniProtKB=C4M4G8	Aldehyde dehydrogenase	IC			PTHR43570:SF16	ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P06959	CCKR signaling map	P07059	BCL2	HUMAN|HGNC=990|UniProtKB=P10415	Apoptosis regulator Bcl-2	RCA	18565785	PubMed	PTHR11256:SF11	APOPTOSIS REGULATOR BCL-2
P00060	Ubiquitin proteasome pathway	P01491	E2	DANRE|ZFIN=ZDB-GENE-030131-408|UniProtKB=B0S6A7	Uncharacterized protein	ISS			PTHR24068:SF41	AT30415P-RELATED
P04393	Ras Pathway	P04557	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	IDA	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	ORNAN|Ensembl=ENSOANG00000010658|UniProtKB=F6V2V1	Uncharacterized protein	ISS	10558991	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00004	Alzheimer disease-presenilin pathway	P00178	BACE-1 pro-domain	HUMAN|HGNC=933|UniProtKB=P56817	Beta-secretase 1	IDA	10531052	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00006	Apoptosis signaling pathway	P00295	Caspase 10	PANTR|Ensembl=ENSPTRG00000012800|UniProtKB=H2R694	Uncharacterized protein	ISS	8755496	PubMed	PTHR10454:SF26	CASPASE-10
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00029	Huntington disease	P00777	CBP	CAEEL|WormBase=WBGene00000366|UniProtKB=P34545	Protein cbp-1	IDA	10823891	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	TAKRU|Ensembl=ENSTRUG00000016224|UniProtKB=H2UWZ9	Uncharacterized protein	ISS			PTHR18945:SF59	ACETYLCHOLINE RECEPTOR SUBUNIT EPSILON
P04393	Ras Pathway	P04570	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MOUSE|MGI=MGI=894644|UniProtKB=Q8CC27	Voltage-dependent L-type calcium channel subunit beta-2	IC	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000006307|UniProtKB=H2SSM1	Uncharacterized protein	ISS			PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000019443|UniProtKB=F6R0Q4	Syntaxin-11	ISS	11067767	PubMed	PTHR19957:SF30	SYNTAXIN-11
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IDA			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04570	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P02741	Flavin biosynthesis	P02940	Riboflavin synthase	DEIRA|EnsemblGenome=DR_0154|UniProtKB=Q9RY00	Riboflavin synthase subunit alpha	ISS			PTHR21098:SF0	RIBOFLAVIN SYNTHASE
P04393	Ras Pathway	P04542	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00375	Calmodulin	ARATH|TAIR=AT3G43810|UniProtKB=P59220	Calmodulin-7	ISS	10487978	PubMed	PTHR23050:SF250	CALMODULIN-7
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00034	Integrin signalling pathway	P00925	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IDA	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ORNAN|Ensembl=ENSOANG00000007405|UniProtKB=F7CIV4	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00034	Integrin signalling pathway	P00906	Rap1	XENTR|Xenbase=XB-GENE-489027|UniProtKB=Q28DY2	RAP2C, member of RAS oncogene family	ISS	8576107	PubMed	PTHR24070:SF200	RAS-RELATED PROTEIN RAP-2C
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00010	B cell activation	P00384	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000018050|UniProtKB=F7ER13	Uncharacterized protein	ISS			PTHR43962:SF2	MELATONIN RECEPTOR TYPE 1A
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	IDA	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00019	Endothelin signaling pathway	P00566	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00305	Caspase 3	RAT|RGD=2275|UniProtKB=P55213	Caspase-3	ISS	11675509	PubMed	PTHR10454:SF198	CASPASE-3
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00018	EGF receptor signaling pathway	P00547	PP2A	PHYPA|Gene=PHYPADRAFT_193894|UniProtKB=A9TD31	Serine/threonine-protein phosphatase	ISS			PTHR11668:SF24	SERINE/THREONINE-PROTEIN PHOSPHATASE 6 CATALYTIC SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	TAS	15572354	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00006	Apoptosis signaling pathway	P00261	Bok	MONDO|Ensembl=ENSMODG00000016075|UniProtKB=F7G9S0	Uncharacterized protein	ISS	9356461	PubMed	PTHR11256:SF48	BCL-2-RELATED OVARIAN KILLER PROTEIN
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000015640|UniProtKB=E2QVF3	Uncharacterized protein	ISS	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00056	VEGF signaling pathway	P01425	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00057	Wnt signaling pathway	P01440	Cadherin	BOVIN|Ensembl=ENSBTAG00000002845|UniProtKB=E1BIA5	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF290	CADHERIN-10
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	MACMU|Ensembl=ENSMMUG00000000293|UniProtKB=F6YFG3	Uncharacterized protein	ISS	1768802	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00752	cGMP-gated ion channel	RAT|RGD=621815|UniProtKB=Q62927	cGMP-gated cation channel alpha-1	IDA	12432397	PubMed	PTHR10217:SF387	CYCLIC NUCLEOTIDE-GATED CHANNEL ROD PHOTORECEPTOR SUBUNIT ALPHA
P00005	Angiogenesis	P00226	Delta/Serrate	MACMU|Ensembl=ENSMMUG00000014541|UniProtKB=F7G756	Delta-like protein	ISS	11798067	PubMed	PTHR24044:SF320	DELTA-LIKE PROTEIN 4
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	SCLS1|EnsemblGenome=SS1G_03482|UniProtKB=A7EDU2	Guanine nucleotide-binding protein beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	MACMU|Ensembl=ENSMMUG00000001758|UniProtKB=F6TN15	Uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF84	CASEIN KINASE I ISOFORM ALPHA
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	DANRE|ZFIN=ZDB-GENE-020125-5|UniProtKB=A2CG69	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF356	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MOUSE|MGI=MGI=88399|UniProtKB=P32211	Muscarinic acetylcholine receptor M4	IDA			PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04542	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00927	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	ARATH|TAIR=AT1G10210|UniProtKB=Q39021	Mitogen-activated protein kinase 1	ISS			PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00057	Wnt signaling pathway	P01452	NFAT	HUMAN|HGNC=7776|UniProtKB=Q13469	Nuclear factor of activated T-cells, cytoplasmic 2	IDA	12015605	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	BOVIN|Ensembl=ENSBTAG00000010740|UniProtKB=P04975	Clathrin light chain B	ISS	9388255	PubMed	PTHR10639:SF2	CLATHRIN LIGHT CHAIN B
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	XENTR|Xenbase=XB-GENE-484248|UniProtKB=F7BH92	Serine/threonine-protein kinase receptor (Fragment)	ISS	11252892	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	HUMAN|HGNC=7852|UniProtKB=O00746	Nucleoside diphosphate kinase, mitochondrial	ISS			PTHR11349:SF49	NUCLEOSIDE DIPHOSPHATE KINASE, MITOCHONDRIAL
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	RAT|RGD=3694|UniProtKB=Q01827	Synaptic vesicular amine transporter	ISS	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	HUMAN|HGNC=4580|UniProtKB=Q13002	Glutamate receptor ionotropic, kainate 2	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00015	Circadian clock system	G01497	cry	MACMU|Ensembl=ENSMMUG00000021808|UniProtKB=F7ENG9	Cryptochrome-1	ISS	10217146	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01163	c-Jun	XENTR|Xenbase=XB-GENE-482228|UniProtKB=F6RYL1	Uncharacterized protein	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	MOUSE|MGI=MGI=1914667|UniProtKB=Q9CXJ1	Probable glutamate--tRNA ligase, mitochondrial	ISS			PTHR43311:SF2	GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED
P00047	PDGF signaling pathway	P01167	Ets	CHICK|Ensembl=ENSGALG00000016058|UniProtKB=Q90837	Transcriptional regulator Erg	ISS	15298723	PubMed	PTHR11849:SF216	TRANSCRIPTIONAL REGULATOR ERG
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	TAS	10747026	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P02756	N-acetylglucosamine metabolism	P03041	Glucosamine-6-phosphate deaminase	HUMAN|HGNC=4417|UniProtKB=P46926	Glucosamine-6-phosphate isomerase 1	ISS			PTHR11280:SF8	GLUCOSAMINE-6-PHOSPHATE ISOMERASE 1
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	CHICK|Ensembl=ENSGALG00000010273|UniProtKB=P48463	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00019	Endothelin signaling pathway	P00591	PLCbeta	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IGI	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00029	Huntington disease	P00790	beta-Tubulin	ORYSJ|EnsemblGenome=OS03G0780600|UniProtKB=P37832	Tubulin beta-7 chain	TAS	12932731	PubMed	PTHR11588:SF146	SUBFAMILY NOT NAMED
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	XENTR|Xenbase=XB-GENE-957124|UniProtKB=F7BDN8	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00022	General transcription by RNA polymerase I	P00651	TAF-IA	DROME|FlyBase=FBgn0002842|UniProtKB=Q9VP40	Spermatocyte arrest	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P06664	Gonadotropin-releasing hormone receptor pathway	P06739	MEK1/2	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	RCA	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P06210	Activin beta signaling pathway	P06238	FUR1	DROME|FlyBase=FBgn0004509|UniProtKB=P26016	Furin-like protease 1, isoforms 1/1-X/2	IEA	7737999	PubMed	PTHR42884:SF3	FURIN-LIKE PROTEASE 1, ISOFORMS 1/1-X/2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	ISS	11535291	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00029	Huntington disease	P00775	Rac	ARATH|TAIR=AT4G35020|UniProtKB=Q38912	Rac-like GTP-binding protein ARAC3	ISS			PTHR24072:SF249	RAC-LIKE GTP-BINDING PROTEIN ARAC3
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	HUMAN|HGNC=145|UniProtKB=P63267	Actin, gamma-enteric smooth muscle	IEP	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00059	p53 pathway	P01486	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	TAS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00244	MAPKAPK2/3	MACMU|Ensembl=ENSMMUG00000010495|UniProtKB=F7BFL2	MAP kinase-activated protein kinase 3	ISS	11157753	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05913	Enkephalin release	P05972	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00019	Endothelin signaling pathway	P00587	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	ANOGA|EnsemblGenome=AGAP001506|UniProtKB=Q7PXP3	AGAP001506-PA	IC			PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00059	p53 pathway	P04633	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	BRAFL|Gene=BRAFLDRAFT_220697|UniProtKB=C3ZSF0	Putative uncharacterized protein	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05731	GABA-B receptor II signaling	P05752	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	MONDO|Ensembl=ENSMODG00000009414|UniProtKB=F7C5D6	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF74	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00006	Apoptosis signaling pathway	P00323	Bcl-xS	RAT|RGD=2200|UniProtKB=P53563	Bcl-2-like protein 1	RCA			PTHR11256:SF12	BCL-2-LIKE PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	MONDO|Ensembl=ENSMODG00000005255|UniProtKB=F7G800	Uncharacterized protein	ISS	7559398	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00021	FGF signaling pathway	P00647	SHP2	MOUSE|MGI=MGI=99511|UniProtKB=P35235	Tyrosine-protein phosphatase non-receptor type 11	IGI	8096088	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	CHICK|Ensembl=ENSGALG00000013781|UniProtKB=F1P1D5	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF344	MYOSIN-7
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-1712|UniProtKB=Q6PBY0	Guanine nucleotide binding protein (G protein), beta 5	ISS	9754712	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00045	Notch signaling pathway	P01110	Presenilin	CANLF|Gene=PSEN1|UniProtKB=Q6RH31	Presenilin-1	ISS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00010	B cell activation	P00397	IKK	HUMAN|HGNC=5960|UniProtKB=O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	IGI	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00254	GTPase	BOVIN|Ensembl=ENSBTAG00000046054|UniProtKB=Q3ZBW5	Rho-related GTP-binding protein RhoB	ISS	13679859	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P06664	Gonadotropin-releasing hormone receptor pathway	P06841	gnaq/11	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	RCA	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00011	Blood coagulation	P00420	GP V	PANTR|Ensembl=ENSPTRG00000015756|UniProtKB=H2QP01	Uncharacterized protein	ISS	4758460	gi	PTHR24373:SF144	PLATELET GLYCOPROTEIN V
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00018	EGF receptor signaling pathway	P00561	STAT	BOVIN|Gene=STAT5A|UniProtKB=Q95115	Signal transducer and activator of transcription 5A	ISS	95236292	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_115291|UniProtKB=C3ZMR2	Putative uncharacterized protein	ISS			PTHR11937:SF359	SUBFAMILY NOT NAMED
P06664	Gonadotropin-releasing hormone receptor pathway	P06847	JNK1/2	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	RCA	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00049	Parkinson disease	P01225	Synphilin	RAT|RGD=1309283|UniProtKB=D3ZWQ5	Protein Sncaip	ISS	10319874	PubMed	PTHR22882:SF3	SYNPHILIN-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	PANTR|Ensembl=ENSPTRG00000016548|UniProtKB=H2QQC5	Uncharacterized protein	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00059	p53 pathway	P01486	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	DICDI|dictyBase=DDB_G0273069|UniProtKB=P22887	Nucleoside diphosphate kinase, cytosolic	ISS			PTHR11349:SF64	NUCLEOSIDE DIPHOSPHATE KINASE HOMOLOG 5
P00019	Endothelin signaling pathway	P00570	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05915	Opioid proenkephalin pathway	P05994	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	IC	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00049	Parkinson disease	P01236	Casein kinase II	CAEEL|WormBase=WBGene00002191|UniProtKB=P18334	Casein kinase II subunit alpha	IDA	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	RCA	7925653	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=19218|UniProtKB=Q86YW0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1	ISS	10934033	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00020	FAS signaling pathway	P00615	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	CHICK|Ensembl=ENSGALG00000007509|UniProtKB=F1NM72	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05913	Enkephalin release	P05972	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04393	Ras Pathway	P04546	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	IDA	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00019	Endothelin signaling pathway	P00590	IP3 R	CAEBR|Gene=CBG_05938|UniProtKB=H8WGV2	Protein CBR-ITR-1, isoform a	ISS	11007872	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00560	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00054	Toll receptor signaling pathway	P01352	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00034	Integrin signalling pathway	P00936	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IPI	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00702	CPB	HUMAN|HGNC=2352|UniProtKB=Q03060	cAMP-responsive element modulator	IDA			PTHR22952:SF97	CAMP-RESPONSIVE ELEMENT MODULATOR
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	CANLF|Ensembl=ENSCAFG00000016066|UniProtKB=E2R7K2	Uncharacterized protein	ISS	11212302	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P05731	GABA-B receptor II signaling	P05755	Gbeta	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DANRE|ZFIN=ZDB-GENE-000330-4|UniProtKB=Q1MTI1	Uncharacterized protein	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IC	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05913	Enkephalin release	P05974	G-Protein (i)	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	G01563	MDM-2	HUMAN|HGNC=6973|UniProtKB=Q00987	E3 ubiquitin-protein ligase Mdm2	IGI	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01095	beta	MACMU|Ensembl=ENSMMUG00000016089|UniProtKB=F7GMZ4	Neuronal acetylcholine receptor subunit beta-2	ISS	22213672	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P02746	Heme biosynthesis	P02980	Coproporphyrinogen Oxidase (oxygen dependent)	NEUCR|EnsemblGenome=EFNCRG00000001909|UniProtKB=F5H9D4	Coproporphyrinogen III oxidase	ISS			PTHR10755:SF0	OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL
P00010	B cell activation	P00381	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	G06046	preproenkephalin mRNA	PANTR|Ensembl=ENSPTRG00000013172|UniProtKB=H2QJT9	Uncharacterized protein	ISS	131330	OMIM	PTHR11438:SF4	PROENKEPHALIN-B
P00057	Wnt signaling pathway	P01444	Wnt	DROME|FlyBase=FBgn0004009|UniProtKB=P09615	Protein wingless	IDA	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00057	Wnt signaling pathway	P01472	Histone deacetylase	PANTR|Ensembl=ENSPTRG00000039785|UniProtKB=H2RGL2	Histone deacetylase	ISS	10485845	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P00034	Integrin signalling pathway	P00947	Laminin	CHICK|Ensembl=ENSGALG00000006802|UniProtKB=E1C700	Uncharacterized protein	IPI	2538453	PubMed	PTHR10574:SF36	LAMININ SUBUNIT BETA-2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	ISS	10514528	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	8920915	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04393	Ras Pathway	P04556	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IDA	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00223	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00023	General transcription regulation	P00664	TFIIH complex	MOUSE|MGI=MGI=1277143|UniProtKB=Q8VD76	General transcription factor IIH subunit 3	ISS			PTHR12831:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00010	B cell activation	P00385	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00006	Apoptosis signaling pathway	P00274	JNK	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12176041	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00004	Alzheimer disease-presenilin pathway	P00148	Erb-B4 N-terminal fragment	PANTR|Ensembl=ENSPTRG00000012883|UniProtKB=H2QJC5	Receptor protein-tyrosine kinase	ISS	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	RCA	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00048	PI3 kinase pathway	P01185	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00023	General transcription regulation	P00662	TFIIA complex	DROME|FlyBase=FBgn0011289|UniProtKB=P52654	Transcription initiation factor IIA subunit 1	ISS	600519	OMIM	PTHR12694:SF8	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	XENTR|Xenbase=XB-GENE-487200|UniProtKB=Q28GC2	Catenin (Cadherin associated protein), beta 1, 88kDa	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00012	Cadherin signaling pathway	P00470	F-actin	BOVIN|Ensembl=ENSBTAG00000014614|UniProtKB=P62739	Actin, aortic smooth muscle	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00021	FGF signaling pathway	P00624	14-3-3	DANRE|ZFIN=ZDB-GENE-030131-779|UniProtKB=Q7ZW20	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1	ISS	12917326	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	BRAFL|Gene=BRAFLDRAFT_220697|UniProtKB=C3ZSF0	Putative uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P05731	GABA-B receptor II signaling	P05758	K channel	RAT|RGD=2958|UniProtKB=P63251	G protein-activated inward rectifier potassium channel 1	ISS	2433589	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00048	PI3 kinase pathway	P01188	Gbetagamma	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CAEEL|WormBase=WBGene00003774|UniProtKB=G5EGQ9	NMDA class glutamate Receptor	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P05918	p38 MAPK pathway	P06031	p38alpha	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	RCA	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00221	JNK1	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CHICK|Ensembl=ENSGALG00000028749|UniProtKB=Q5ZMQ2	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00005	Angiogenesis	P00203	Erk	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01164	PDK1/2	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	ISS	11256888	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04398	p53 pathway feedback loops 2	P04657	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00046	Oxidative stress response	P01129	JNK1/2	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	TAS	12040174	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00004	Alzheimer disease-presenilin pathway	P00123	CD44 C-terminal fragment	RAT|RGD=2307|UniProtKB=P26051	CD44 antigen	IDA	12223485	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P00048	PI3 kinase pathway	P01194	S6K	MACMU|Ensembl=ENSMMUG00000019305|UniProtKB=F6S3T8	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00004	Alzheimer disease-presenilin pathway	P00170	Aph-1	ARATH|TAIR=AT2G31440|UniProtKB=Q8L9G7	Gamma-secretase subunit APH1-like	IDA	12110170	PubMed	PTHR12889:SF0	GAMMA-SECRETASE SUBUNIT APH-1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01444	Wnt	XENTR|Gene=wnt11b-1|UniProtKB=Q66II0	Protein Wnt-11b-1	ISS	11266476	PubMed	PTHR12027:SF34	PROTEIN WNT
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	RAT|RGD=3227|UniProtKB=P09057	Ornithine decarboxylase	ISS			PTHR11482:SF42	ORNITHINE DECARBOXYLASE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	MOUSE|MGI=MGI=1338071|UniProtKB=O88351	Inhibitor of nuclear factor kappa-B kinase subunit beta	IDA	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	CAEBR|Gene=CBG16677|UniProtKB=A8XPA7	Protein CBG16677	ISS	10487978	PubMed	PTHR10749:SF7	PHOSPHORYLASE B KINASE REGULATORY SUBUNIT ALPHA-RELATED
P00012	Cadherin signaling pathway	P00466	EGFR	MOUSE|MGI=MGI=95411|UniProtKB=Q61526	Receptor tyrosine-protein kinase erbB-3	ISS	20477399	gi	PTHR24416:SF88	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3
P00047	PDGF signaling pathway	P01160	IP3 receptor	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P05916	Opioid prodynorphin pathway	P06002	G-protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05916	Opioid prodynorphin pathway	P06002	G-protein	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	TAS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05944	COMT	HUMAN|HGNC=2228|UniProtKB=P21964	Catechol O-methyltransferase	ISS	12842307	PubMed	PTHR43836:SF3	CATECHOL O-METHYLTRANSFERASE
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MOUSE|MGI=MGI=103189|UniProtKB=Q10738	Matrilysin	IEP	12356903	PubMed	PTHR10201:SF143	MATRILYSIN
P00048	PI3 kinase pathway	P01199	Galpha	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	IC	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	MOUSE|MGI=MGI=88547|UniProtKB=O54833	Casein kinase II subunit alpha'	IDA	10806215	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00049	Parkinson disease	P01223	UbcH8	PANTR|Ensembl=ENSPTRG00000003661|UniProtKB=H2Q3P2	Ubiquitin-conjugating enzyme E2L 6	ISS	11078524	PubMed	PTHR24068:SF43	UBIQUITIN/ISG15-CONJUGATING ENZYME E2 L6
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05730	Endogenous cannabinoid signaling	P05751	Galpha	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00047	PDGF signaling pathway	P01175	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	95096035	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	SCHPO|PomBase=SPAC6G9.11|UniProtKB=Q92356	Synaptobrevin homolog 1	ISS	10414292	PubMed	PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00048	PI3 kinase pathway	P01179	PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05752	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00568	PKC	CANAL|CGD=CAL0003231|UniProtKB=Q5ANK2	Protein kinase C	IGI	125549	gi	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	DROME|FlyBase=FBgn0028410|UniProtKB=Q9VK37	Pk34A	ISS			PTHR24056:SF7	PK34A
P00057	Wnt signaling pathway	P01444	Wnt	TAKRU|Ensembl=ENSTRUG00000011562|UniProtKB=H2TX02	Protein Wnt	IDA	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00029	Huntington disease	P00796	Kainate receptor	BOVIN|Ensembl=ENSBTAG00000034854|UniProtKB=F1N246	Uncharacterized protein	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=94925|UniProtKB=P30728	D(3) dopamine receptor	IDA	11861492	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00019	Endothelin signaling pathway	P00589	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IGI	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	PANTR|Ensembl=ENSPTRG00000017549|UniProtKB=H2QS18	Dopamine receptor D1	ISS	9700720	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	MACMU|Ensembl=ENSMMUG00000017143|UniProtKB=F7H113	Uncharacterized protein	ISS	11907044	PubMed	PTHR44025:SF5	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT1G01560|UniProtKB=Q9LMM5	Mitogen-activated protein kinase 11	ISS	12787066	PubMed	PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00047	PDGF signaling pathway	P01150	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	HUMAN|HGNC=10432|UniProtKB=P51812	Ribosomal protein S6 kinase alpha-3	ISS	10480933	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	IC	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHLRE|EnsemblGenome=CHLREDRAFT_168932|UniProtKB=O24426	Actin-like protein	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	NAS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	TAKRU|Ensembl=ENSTRUG00000011169|UniProtKB=H2TU36	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	DANRE|ZFIN=ZDB-GENE-030131-55|UniProtKB=Q6XNL8	Actin	IC	14684598	PubMed	PTHR11937:SF263	ACTIN
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00035	Interferon-gamma signaling pathway	P00960	PTP	CANLF|Ensembl=ENSCAFG00000008894|UniProtKB=F1Q3J6	Tyrosine-protein phosphatase non-receptor type	ISS	14525967	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	2372396	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000000365|UniProtKB=F6R9F4	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P05913	Enkephalin release	P05973	GPCR (i)	PANTR|Ensembl=ENSPTRG00000000440|UniProtKB=H2PYH8	Uncharacterized protein	ISS	11259487	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00021	FGF signaling pathway	P00633	Ras	CAEEL|WormBase=WBGene00002335|UniProtKB=P22981	Ras protein let-60	IGI	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00036	Interleukin signaling pathway	P00989	Ets	HUMAN|HGNC=29549|UniProtKB=Q8N5J4	Transcription factor Spi-C	TAS	8970723	PubMed	PTHR11849:SF17	TRANSCRIPTION FACTOR SPI-C
P00036	Interleukin signaling pathway	P00981	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	TAS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	11554554	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04393	Ras Pathway	P04542	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00552	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IGI	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P00048	PI3 kinase pathway	P01199	Galpha	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00001	Adrenaline and noradrenaline biosynthesis	P00061	PNMT	MOUSE|MGI=MGI=102963|UniProtKB=P40936	Indolethylamine N-methyltransferase	ISS			PTHR10867:SF6	INDOLETHYLAMINE N-METHYLTRANSFERASE-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00029	Huntington disease	P00807	Actin	CAEEL|WormBase=WBGene00000065|UniProtKB=P0DM42	Actin-3	IDA	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	PANTR|Ensembl=ENSPTRG00000014922|UniProtKB=H2QML4	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00057	Wnt signaling pathway	P01465	Ggamma	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P02775	Salvage pyrimidine ribonucleotides	P03152	Uridine phosphorylase	DROME|FlyBase=FBgn0034800|UniProtKB=Q8T8S2	Uridine phosphorylase	ISS			PTHR43691:SF3	URIDINE PHOSPHORYLASE 1
P00059	p53 pathway	P01486	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	BOVIN|Ensembl=ENSBTAG00000010386|UniProtKB=Q3MHR7	Actin-related protein 2/3 complex subunit 2	ISS	10940259	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00010	B cell activation	P00398	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00005	Angiogenesis	P00190	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00048	PI3 kinase pathway	P01203	p101	CANLF|Ensembl=ENSCAFG00000017387|UniProtKB=E2RLD1	Uncharacterized protein	ISS	12507995	PubMed	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00037	Ionotropic glutamate receptor pathway	P01026	KA	TAKRU|Ensembl=ENSTRUG00000009259|UniProtKB=H2TF39	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	IDA	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	SCHPO|PomBase=SPAC17H9.09c|UniProtKB=P08647	Ras-like protein 1	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00052	TGF-beta signaling pathway	P01284	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00049	Parkinson disease	P01230	Src kinase	DANRE|ZFIN=ZDB-GENE-050706-89|UniProtKB=F1RDG9	Tyrosine-protein kinase fynb	ISS	9741627	PubMed	PTHR24418:SF242	TYROSINE-PROTEIN KINASE FYNB
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PANTR|Ensembl=ENSPTRG00000017674|UniProtKB=H2Q189	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	RAT|RGD=619877|UniProtKB=P19804	Nucleoside diphosphate kinase B	ISS			PTHR11349:SF57	NUCLEOSIDE DIPHOSPHATE KINASE B
P05731	GABA-B receptor II signaling	P05754	Ggamma	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	ISS	11554549	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00005	Angiogenesis	P00219	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MOUSE|MGI=MGI=95822|UniProtKB=Q01098	Glutamate receptor ionotropic, NMDA 2C	IC	11554549	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	TAS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00025	Hedgehog signaling pathway	P00682	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00114	actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g169611|UniProtKB=A7SEB1	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05913	Enkephalin release	P05974	G-Protein (i)	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P04628	14-3-3	PANTR|Ensembl=ENSPTRG00000030723|UniProtKB=H2RC87	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF14	14-3-3 PROTEIN SIGMA
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01082	AC	MACMU|Ensembl=ENSMMUG00000010380|UniProtKB=F7D9M6	Uncharacterized protein	ISS	9874775	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=98953|UniProtKB=P04426	Proto-oncogene Wnt-1	TAS	14644163	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DAPPU|EnsemblGenome=DAPPUDRAFT_228751|UniProtKB=E9HGF5	Cytoplasmatic actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00005	Angiogenesis	P00189	Fzd	CANLF|Ensembl=ENSCAFG00000008293|UniProtKB=E2R9M9	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF22	FRIZZLED-3
P05731	GABA-B receptor II signaling	P05755	Gbeta	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00009	Axon guidance mediated by netrin	P00363	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001749|UniProtKB=H2Q0Q4	Uncharacterized protein	ISS	8386525	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00048	PI3 kinase pathway	P01188	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=620146|UniProtKB=O08874	Serine/threonine-protein kinase N2	ISS	125549	gi	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00047	PDGF signaling pathway	P01171	PLCgamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04397	p53 pathway by glucose deprivation	P04645	TSC1	PANTR|Ensembl=ENSPTRG00000021504|UniProtKB=H2QY35	Tuberous sclerosis 1	ISS	12167664	PubMed	PTHR15154:SF2	HAMARTIN
P02748	Isoleucine biosynthesis	P02995	Threonine dehydratase	CAEEL|WormBase=WBGene00010456|UniProtKB=Q21080	Uncharacterized protein	ISS			PTHR43419:SF10	SUBFAMILY NOT NAMED
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00049	Parkinson disease	P01211	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01446	Calcineurin	XENTR|Xenbase=XB-GENE-952299|UniProtKB=B0BLZ8	Serine/threonine-protein phosphatase	ISS	7532676	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	MACMU|Ensembl=ENSMMUG00000008569|UniProtKB=F6UPU0	Uncharacterized protein	ISS	604905	OMIM	PTHR15319:SF1	TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT C
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	BOVIN|Ensembl=ENSBTAG00000018035|UniProtKB=O46680	TGF-beta receptor type-1	TAS	9395284	PubMed	PTHR23255:SF61	TGF-BETA RECEPTOR TYPE-1
P04397	p53 pathway by glucose deprivation	P04641	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00848	Grb	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	DROME|FlyBase=FBgn0019947|UniProtKB=O02194	Presenilin homolog	TAS	12369105	PubMed	PTHR10202:SF13	PRESENILIN-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00589	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	DANRE|ZFIN=ZDB-GENE-020604-1|UniProtKB=Q6IQX1	Myosin, heavy polypeptide 2, fast muscle specific	IC	89264452	PubMed	PTHR13140:SF676	MYOSIN, HEAVY POLYPEPTIDE 2, FAST MUSCLE SPECIFIC
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	DICDI|dictyBase=DDB_G0275617|UniProtKB=P26355	TATA-box-binding protein	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00047	PDGF signaling pathway	P01155	Jak	CANLF|Ensembl=ENSCAFG00000002102|UniProtKB=E2RPW6	Tyrosine-protein kinase	ISS	22482294	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P02743	Formyltetrahydroformate biosynthesis	P02954	Thymidylate synthase	BACSU|EnsemblGenome=BSU21820|UniProtKB=P11044	Thymidylate synthase 2	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	TAS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00383	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	CAEEL|WormBase=WBGene00000117|UniProtKB=Q20352	ALdehyde deHydrogenase	IC			PTHR11699:SF228	4-TRIMETHYLAMINOBUTYRALDEHYDE DEHYDROGENASE
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00057	Wnt signaling pathway	P01438	PP2A	HUMAN|HGNC=9312|UniProtKB=Q14738	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	IDA	10092233	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00012	Cadherin signaling pathway	P00477	GSK3beta	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02723	Adenine and hypoxanthine salvage pathway	P02807	Deoxyadenosine deaminase	HUMAN|HGNC=186|UniProtKB=P00813	Adenosine deaminase	ISS			PTHR11409:SF43	ADENOSINE DEAMINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	BOVIN|Ensembl=ENSBTAG00000010191|UniProtKB=Q08E52	Serine/threonine-protein kinase PAK 1	ISS	14580336	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P06959	CCKR signaling map	P07134	PKCdelta	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	RCA	9230117	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	CANLF|Ensembl=ENSCAFG00000005606|UniProtKB=E2RE16	Uncharacterized protein	ISS			PTHR24361:SF345	SERINE/THREONINE-PROTEIN KINASE PAK 4
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00018	EGF receptor signaling pathway	P00544	c-Cbl	HUMAN|HGNC=1542|UniProtKB=Q13191	E3 ubiquitin-protein ligase CBL-B	IGI	95303504	PubMed	PTHR23007:SF3	E3 UBIQUITIN-PROTEIN LIGASE CBL-B
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04393	Ras Pathway	P04572	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04398	p53 pathway feedback loops 2	P04661	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01199	Galpha	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00561	STAT	DANRE|ZFIN=ZDB-GENE-980526-499|UniProtKB=Q6P943	Signal transducer and activator of transcription	IGI	10417824	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00010	B cell activation	P00371	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	MOUSE|MGI=MGI=99460|UniProtKB=Q61982	Neurogenic locus notch homolog protein 3	IDA	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	NEUCR|EnsemblGenome=EFNCRG00000000159|UniProtKB=F5HH30	Guanine nucleotide-binding protein beta subunit	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P06959	CCKR signaling map	P07031	p70S6K1	HUMAN|HGNC=10436|UniProtKB=P23443	Ribosomal protein S6 kinase beta-1	RCA	9252447	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	MOUSE|MGI=MGI=1339946|UniProtKB=P62340	TATA box-binding protein-like protein 1	ISS	600075	OMIM	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00760	Gtalpha	MONDO|Ensembl=ENSMODG00000012279|UniProtKB=F6YFY5	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF67	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-1
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00010	B cell activation	P00384	p38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	IDA	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00047	PDGF signaling pathway	P01162	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00049	Parkinson disease	P01212	p38 MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00047	PDGF signaling pathway	P01160	IP3 receptor	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05916	Opioid prodynorphin pathway	P06000	vasopressin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P05730	Endogenous cannabinoid signaling	P05746	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05913	Enkephalin release	P05974	G-Protein (i)	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00035	Interferon-gamma signaling pathway	P00958	PIAS	RAT|RGD=1308737|UniProtKB=B5DFF9	Pias4 protein	ISS	8682149	PubMed	PTHR10782:SF9	E3 SUMO-PROTEIN LIGASE PIAS4
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	TAS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	10693759	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00547	PP2A	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05917	Opioid proopiomelanocortin pathway	P06006	beta-Endorphin	MOUSE|MGI=MGI=97742|UniProtKB=P01193	Pro-opiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00010	B cell activation	P00391	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01457	GBeta	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00019	Endothelin signaling pathway	P00570	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00909	ASAP1	CAEEL|WormBase=WBGene00010500|UniProtKB=P90904	Uncharacterized protein	IPI			PTHR23180:SF35	ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00029	Huntington disease	P00777	CBP	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04395	Vasopressin synthesis	P04597	Signal Peptide	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00927	Rac	ENTHI|EnsemblGenome=EHI_197840|UniProtKB=C4M8K6	Rho family GTPase	IGI	12932731	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	PLAF7|EnsemblGenome=PF14_0124|UniProtKB=Q8ILW9	Actin-2	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00059	p53 pathway	G04702	p53	BOVIN|Ensembl=ENSBTAG00000005812|UniProtKB=G3X6J7	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	IC	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00053	T cell activation	P01320	PLC-gamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00053	T cell activation	P01332	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00243	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04395	Vasopressin synthesis	P04596	Endo Peptidase	CHICK|Gene_ORFName=RCJMB04_10c4|UniProtKB=Q5ZKL5	Prolyl endopeptidase-like	IC	9695945	PubMed	PTHR11757:SF12	PROLYL ENDOPEPTIDASE-LIKE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	MONDO|Ensembl=ENSMODG00000025146|UniProtKB=F7CLC0	Uncharacterized protein	ISS			PTHR23050:SF311	CALMODULIN
P00047	PDGF signaling pathway	P01162	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00046	Oxidative stress response	P01132	c-jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00018	EGF receptor signaling pathway	P00552	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00046	Oxidative stress response	P01131	MKP5	PANTR|Ensembl=ENSPTRG00000020129|UniProtKB=H2QVZ4	Dual specificity protein phosphatase	ISS			PTHR10159:SF111	DUAL SPECIFICITY PROTEIN PHOSPHATASE 4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IC	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHICK|Ensembl=ENSGALG00000009844|UniProtKB=P68034	Actin, alpha cardiac muscle 1	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00859	NFkappaB	RAT|RGD=1307189|UniProtKB=Q5U2Z4	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	ISS	12574369	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT1G10210|UniProtKB=Q39021	Mitogen-activated protein kinase 1	ISS	10851062	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00052	TGF-beta signaling pathway	P01275	P38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	TAS	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00018	EGF receptor signaling pathway	P00546	GAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00053	T cell activation	P01300	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	TAKRU|Ensembl=ENSTRUG00000013411|UniProtKB=H2UB84	Uncharacterized protein	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00011	Blood coagulation	P00430	FX	RAT|RGD=61850|UniProtKB=Q63207	Coagulation factor X	ISS	8393340	gi	PTHR44064:SF3	COAGULATION FACTOR X
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01160	IP3 receptor	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00057	Wnt signaling pathway	P01448	CBP	BOVIN|Ensembl=ENSBTAG00000016198|UniProtKB=E1B8D6	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	XENTR|Ensembl=ENSXETG00000030841|UniProtKB=F7C5A3	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF18	PROTEIN-SERINE/THREONINE KINASE
P00021	FGF signaling pathway	P00645	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00005	Angiogenesis	P00233	CSL	RAT|RGD=1304786|UniProtKB=D4AEG0	Protein Rbpjl	ISS	12681948	PubMed	PTHR10665:SF2	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS-LIKE PROTEIN
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	MOUSE|MGI=MGI=1933206|UniProtKB=A2AIR5	Protein Grin3a	ISS	14698601	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00057	Wnt signaling pathway	P01443	Phospholipase C	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=12780|UniProtKB=P09544	Protein Wnt-2	TAS	8717036	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00029	Huntington disease	P00790	beta-Tubulin	ARATH|TAIR=AT5G44340|UniProtKB=P24636	Tubulin beta-4 chain	TAS	9454836	PubMed	PTHR11588:SF245	TUBULIN BETA-4 CHAIN-RELATED
P00018	EGF receptor signaling pathway	P00547	PP2A	CHICK|Ensembl=ENSGALG00000011840|UniProtKB=F1NLM6	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	MACMU|Ensembl=ENSMMUG00000000893|UniProtKB=F6T7D0	Histone acetyltransferase p300	ISS	10664585	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	TAKRU|Ensembl=ENSTRUG00000015938|UniProtKB=H2UUX5	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00059	p53 pathway	P04623	CBP	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	IDA	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00054	Toll receptor signaling pathway	P01360	IKKbeta	HUMAN|HGNC=5960|UniProtKB=O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00049	Parkinson disease	P01242	Casein kinase I	DROME|FlyBase=FBgn0002413|UniProtKB=O76324	Discs overgrown protein kinase	IDA	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00005	Angiogenesis	P00206	Wnt	HUMAN|HGNC=12774|UniProtKB=P04628	Proto-oncogene Wnt-1	IDA	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	DROME|FlyBase=FBgn0027343|UniProtKB=O77438	Frizzled-3	TAS	8717036	PubMed	PTHR11309:SF125	FRIZZLED-3
P05915	Opioid proenkephalin pathway	P05994	G-protein	CAEEL|WormBase=WBGene00001679|UniProtKB=P17343	Guanine nucleotide-binding protein subunit beta-1	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00004	Alzheimer disease-presenilin pathway	P00149	Pen-2	HUMAN|HGNC=30100|UniProtKB=Q9NZ42	Gamma-secretase subunit PEN-2	IDA	12110170	PubMed	PTHR16318:SF0	GAMMA-SECRETASE SUBUNIT PEN-2
P00037	Ionotropic glutamate receptor pathway	P01001	KA4	MONDO|Ensembl=ENSMODG00000013079|UniProtKB=F7FB74	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00046	Oxidative stress response	P01135	p38	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	TAS	10995439	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00053	T cell activation	P01302	CD3 eta	PANTR|Ensembl=ENSPTRG00000004338|UniProtKB=H2Q4V9	Uncharacterized protein	ISS	9886373	PubMed	PTHR10570:SF9	T-CELL SURFACE GLYCOPROTEIN CD3 EPSILON CHAIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	HUMAN|HGNC=29419|UniProtKB=Q5JPH6	Probable glutamate--tRNA ligase, mitochondrial	ISS			PTHR43311:SF2	GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED
P00048	PI3 kinase pathway	P01177	P110ACT	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	HUMAN|HGNC=8746|UniProtKB=Q6UW60	Proprotein convertase subtilisin/kexin type 4	IDA			PTHR42884:SF16	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 4
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00624	14-3-3	MOUSE|MGI=MGI=1891917|UniProtKB=Q9CQV8	14-3-3 protein beta/alpha	ISS	10407019	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00034	Integrin signalling pathway	P00922	Collagen	PANTR|Ensembl=ENSPTRG00000020539|UniProtKB=H2QWM9	Collagen, type XIV, alpha 1	ISS	10778855	PubMed	PTHR44557:SF1	COLLAGEN ALPHA-1 XIV  CHAIN
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	TAKRU|Ensembl=ENSTRUG00000013411|UniProtKB=H2UB84	Uncharacterized protein	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CHICK|Ensembl=ENSGALG00000017178|UniProtKB=F1N982	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04665	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04398	p53 pathway feedback loops 2	P04665	AKT	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	BOVIN|Ensembl=ENSBTAG00000019337|UniProtKB=F1MMW7	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF58	ACTIVIN RECEPTOR TYPE-1C
P00005	Angiogenesis	P00210	eNOS	BOVIN|Gene=NOS3|UniProtKB=P29473	Nitric oxide synthase, endothelial	ISS	9837777	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MOUSE|MGI=MGI=95822|UniProtKB=Q01098	Glutamate receptor ionotropic, NMDA 2C	ISS	14698601	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00012	Cadherin signaling pathway	P00470	F-actin	DROME|FlyBase=FBgn0000044|UniProtKB=P53501	Actin-57B	IC	14684598	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	IDA	11956331	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=69430|UniProtKB=P32851	Syntaxin-1A	IC	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00049	Parkinson disease	P01211	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00059	p53 pathway	P04634	Cdc2	DANRE|ZFIN=ZDB-GENE-040426-2741|UniProtKB=Q7ZWB1	Cyclin-dependent kinase 2	ISS	15660127	PubMed	PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02746	Heme biosynthesis	P02975	Uroporphyrinogen decarboxylase	DEIRA|EnsemblGenome=DR_1133|UniProtKB=Q9RV96	Uroporphyrinogen decarboxylase	ISS			PTHR21091:SF2	UROPORPHYRINOGEN DECARBOXYLASE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MACMU|Ensembl=ENSMMUG00000018445|UniProtKB=F7HEW6	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00052	TGF-beta signaling pathway	P01279	Smurfs	DANRE|ZFIN=ZDB-GENE-030131-1830|UniProtKB=A9JRZ0	E3 ubiquitin-protein ligase SMURF2	ISS	11252892	PubMed	PTHR11254:SF300	E3 UBIQUITIN-PROTEIN LIGASE SMURF2
P00019	Endothelin signaling pathway	P00575	furin	MOUSE|MGI=MGI=97513|UniProtKB=P23188	Furin	ISS	95328031	PubMed	PTHR42884:SF1	FURIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MONDO|Ensembl=ENSMODG00000012009|UniProtKB=F7AMI2	Uncharacterized protein	ISS	12181435	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P00014	Cholesterol biosynthesis	P00495	Isopentenyl diphosphate delta-isomerase	MOUSE|MGI=MGI=2444315|UniProtKB=Q8BFZ6	Isopentenyl-diphosphate delta-isomerase 2	ISS	6225528	gi	PTHR10885:SF2	ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE 2
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00029	Huntington disease	P00807	Actin	PANTR|Ensembl=ENSPTRG00000018890|UniProtKB=Q5R1X3	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MONDO|Ensembl=ENSMODG00000012546|UniProtKB=F6PM16	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00912	Arp2/3	MONDO|Ensembl=ENSMODG00000001303|UniProtKB=F7BZM9	Uncharacterized protein (Fragment)	ISS	12473693	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00052	TGF-beta signaling pathway	P01284	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	TAS	11707292	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00018	EGF receptor signaling pathway	P00557	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IGI	129387	gi	PTHR10048:SF14	PI-3 KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ARATH|TAIR=AT5G53540|UniProtKB=Q9FJC9	26S proteasome regulatory particle chain RPT6-like protein	ISS			PTHR23074:SF20	GH08677P
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MOUSE|MGI=MGI=1338944|UniProtKB=Q61271	Activin receptor type-1B	TAS	10683140	PubMed	PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CAEEL|WormBase=WBGene00016509|UniProtKB=P91134	Adenylosuccinate synthetase	IEP	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00006	Apoptosis signaling pathway	P00259	TNF	BOVIN|Ensembl=ENSBTAG00000025471|UniProtKB=Q06599	Tumor necrosis factor	ISS	11911478	PubMed	PTHR11471:SF23	TUMOR NECROSIS FACTOR
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00047	PDGF signaling pathway	P01143	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01235	Fyn kinase	MOUSE|MGI=MGI=95602|UniProtKB=P39688	Tyrosine-protein kinase Fyn	IDA	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00591	PLCbeta	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT3G45640|UniProtKB=Q39023	Mitogen-activated protein kinase 3	IDA			PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	ANOGA|EnsemblGenome=AGAP001478|UniProtKB=Q7PXM3	AGAP001478-PA	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00006	Apoptosis signaling pathway	P00292	IkappaB	MOUSE|MGI=MGI=104741|UniProtKB=Q9Z1E3	NF-kappa-B inhibitor alpha	ISS	10811867	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00010	B cell activation	P00371	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	MOUSE|MGI=MGI=1930705|UniProtKB=P61264	Syntaxin-1B	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00005	Angiogenesis	P00238	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	BOVIN|Ensembl=ENSBTAG00000001067|UniProtKB=E1BAB4	Uncharacterized protein	ISS			PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00013	Cell cycle	P00480	Proteasome	ORNAN|Ensembl=ENSOANG00000006175|UniProtKB=F7AZ85	Uncharacterized protein	ISS	9727008	PubMed	PTHR10410:SF5	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 14
P00036	Interleukin signaling pathway	P00964	p90RSK	PANTR|Ensembl=ENSPTRG00000000387|UniProtKB=H2PYE3	Ribosomal protein S6 kinase	ISS	12213813	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	MONDO|Ensembl=ENSMODG00000019001|UniProtKB=F7CP86	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01230	Src kinase	HUMAN|HGNC=3697|UniProtKB=P09769	Tyrosine-protein kinase Fgr	IDA	11078745	PubMed	PTHR24418:SF224	TYROSINE-PROTEIN KINASE FGR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MACMU|Ensembl=ENSMMUG00000006421|UniProtKB=F6U2K7	Uncharacterized protein	ISS	89298382	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	MACMU|Ensembl=ENSMMUG00000022513|UniProtKB=F6YNZ0	Uncharacterized protein	ISS	20012997	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00021	FGF signaling pathway	P00623	FGF	XENTR|Xenbase=XB-GENE-484332|UniProtKB=L7N2H4	Fibroblast growth factor	ISS	12496262	PubMed	PTHR11486:SF77	FIBROBLAST GROWTH FACTOR 13
P00049	Parkinson disease	P01219	SAPK	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	4506785	gi	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1170702	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	RCA			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	P01451	Galpha	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	IDA	9166716	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	TAS	3045562	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00049	Parkinson disease	P01236	Casein kinase II	SCLS1|EnsemblGenome=SS1G_12241|UniProtKB=A7F2U3	Casein kinase II	ISS	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00059	p53 pathway	P04619	HMG1	RAT|RGD=1588759|UniProtKB=D3ZGW6	Protein Hmgb1-ps3	ISS			PTHR13711:SF164	HIGH MOBILITY GROUP PROTEIN B1-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00059	p53 pathway	G01563	MDM-2	PANTR|Ensembl=ENSPTRG00000005203|UniProtKB=H2R792	Mdm2 p53 binding protein homolog	ISS	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	ARATH|TAIR=AT4G01370|UniProtKB=Q39024	Mitogen-activated protein kinase 4	ISS			PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	YARLI|EnsemblGenome=YALI0_D16863g|UniProtKB=Q6C8U8	YALI0D16863p	IDA	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	MACMU|Ensembl=ENSMMUG00000001060|UniProtKB=F6QN17	Uncharacterized protein	ISS	15858232	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00048	PI3 kinase pathway	P01190	PDK1 ACT	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	IDA	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00048	PI3 kinase pathway	P01192	p110	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	LEIMA|EnsemblGenome=LmjF.04.1210|UniProtKB=O96999	Putative casein kinase I	IDA	11437445	PubMed	PTHR11909:SF292	SUBFAMILY NOT NAMED
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04393	Ras Pathway	P04570	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	IDA	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	DROME|FlyBase=FBgn0022710|UniProtKB=M9PEP2	Adenylyl cyclase 35C, isoform C	IGI	2491850	PubMed	PTHR11920:SF319	ADENYLATE CYCLASE TYPE 9
P00029	Huntington disease	P00807	Actin	MOUSE|MGI=MGI=87904|UniProtKB=P60710	Actin, cytoplasmic 1	IDA	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00019	Endothelin signaling pathway	P00572	MEK	CAEBR|Gene=CBG04190|UniProtKB=A8WWD7	Protein CBR-MEK-2	ISS	22022015	PubMed	PTHR24361:SF629	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	8687404	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00053	T cell activation	P01300	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02744	Fructose galactose metabolism	P02966	Hexokinase	ENTHI|EnsemblGenome=EHI_098560|UniProtKB=Q27648	Phosphotransferase	IDA	8577326	PubMed	PTHR19443:SF16	PHOSPHOTRANSFERASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00029	Huntington disease	P00780	Microtubule	CAEEL|WormBase=WBGene00006539|UniProtKB=G5EF01	TuBulin, Beta	IDA	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00049	Parkinson disease	P01217	beta-Synuclein	MOUSE|MGI=MGI=1889011|UniProtKB=Q91ZZ3	Beta-synuclein	IDA	11683992	PubMed	PTHR13820:SF4	BETA-SYNUCLEIN
P00005	Angiogenesis	P00233	CSL	HUMAN|HGNC=5724|UniProtKB=Q06330	Recombining binding protein suppressor of hairless	IDA	8406481	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00036	Interleukin signaling pathway	P00997	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P02762	Pentose phosphate pathway	P03071	Ribulose 5-P Isomerase	ECOLI|EcoGene=EG10055|UniProtKB=P08203	L-ribulose-5-phosphate 4-epimerase	ISS	11732895	PubMed	PTHR22789:SF15	L-RIBULOSE-5-PHOSPHATE 4-EPIMERASE
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	PANTR|Ensembl=ENSPTRG00000000843|UniProtKB=H2QZN8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00029	Huntington disease	P00807	Actin	PHYPA|Gene=PHYPADRAFT_172686|UniProtKB=A9TYG6	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00034	Integrin signalling pathway	P00922	Collagen	MOUSE|MGI=MGI=88467|UniProtKB=P11087	Collagen alpha-1(I) chain	IDA	10778855	PubMed	PTHR24023:SF569	COLLAGEN ALPHA-1 I  CHAIN
P00054	Toll receptor signaling pathway	P01356	ERK2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00965	ERK	MACMU|Ensembl=ENSMMUG00000001187|UniProtKB=F6R8N9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	BOVIN|Ensembl=ENSBTAG00000014447|UniProtKB=A4IFF4	Ribosomal protein S6 kinase	ISS	12213813	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CANLF|Ensembl=ENSCAFG00000008756|UniProtKB=F2Z4N8	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06704	GnRH	MOUSE|MGI=MGI=95789|UniProtKB=P13562	Progonadoliberin-1	RCA			PTHR10522:SF0	PROGONADOLIBERIN-1
P02738	De novo purine biosynthesis	P02906	N5-carboxyaminoimidazole ribonucleotide synthase	BACTN|EnsemblGenome=BT_2518|UniProtKB=Q8A4S9	N5-carboxyaminoimidazole ribonucleotide mutase	ISS			PTHR23046:SF2	N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE MUTASE
P00022	General transcription by RNA polymerase I	P00657	TBP	RAT|RGD=1597456|UniProtKB=D4A898	Protein Tbpl1	ISS	600075	OMIM	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00051	TCA cycle	P01266	Pyruvate Dehydrogenase	MOUSE|MGI=MGI=97532|UniProtKB=P35486	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial	RCA			PTHR11516:SF51	PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA, SOMATIC FORM, MITOCHONDRIAL
P00049	Parkinson disease	P01208	Hsp70	YEAST|SGD=S000003571|UniProtKB=P16474	78 kDa glucose-regulated protein homolog	IDA	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DANRE|ZFIN=ZDB-GENE-030131-1229|UniProtKB=Q6DHS1	Actin, alpha 2, smooth muscle, aorta	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00644	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00052	TGF-beta signaling pathway	P01275	P38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	TAS	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MONDO|Ensembl=ENSMODG00000001933|UniProtKB=F6W0P2	Uncharacterized protein (Fragment)	ISS	10188796	PubMed	PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P00012	Cadherin signaling pathway	P00474	Wnt	RAT|RGD=621346|UniProtKB=Q2IBD1	Protein Wnt	IDA	8717036	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	EMENI|EnsemblGenome=CADANIAG00006669|UniProtKB=G5EB74	Uncharacterized protein	IC			PTHR22914:SF16	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	IDA	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	PANTR|Ensembl=ENSPTRG00000013902|UniProtKB=H2RCL0	Uncharacterized protein	ISS	12374786	PubMed	PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P02747	Histidine biosynthesis	P02985	Histidinol dehydrogenase	BACTN|EnsemblGenome=BT_0201|UniProtKB=Q8ABA9	Histidinol dehydrogenase	ISS			PTHR21256:SF2	HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN
P00010	B cell activation	P00401	jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IDA	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00981	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00008	Axon guidance mediated by Slit/Robo	P00344	Netrin	MOUSE|MGI=MGI=105088|UniProtKB=O09118	Netrin-1	ISS	9427245	PubMed	PTHR10574:SF365	NETRIN-1
P00056	VEGF signaling pathway	P01413	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	ISS	96009592	PubMed	PTHR10048:SF14	PI-3 KINASE
P00029	Huntington disease	P00774	Dynein complex	PRIPA|Gene=PPA10291|UniProtKB=H3EKK6	Uncharacterized protein	ISS	9454836	PubMed	PTHR11886:SF35	DYNEIN LIGHT CHAIN 2, CYTOPLASMIC
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	BOVIN|Ensembl=ENSBTAG00000005464|UniProtKB=E1B9K3	Uncharacterized protein	ISS	93028552	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01067	AChE	CAEBR|Gene=CBG14965|UniProtKB=A8XL40	Carboxylic ester hydrolase	ISS	87080761	PubMed	PTHR43918:SF6	CARBOXYLIC ESTER HYDROLASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00010	B cell activation	P00400	Btk	MACMU|Ensembl=ENSMMUG00000019573|UniProtKB=F7BGK5	Tyrosine-protein kinase	ISS	10521450	PubMed	PTHR24418:SF92	TYROSINE-PROTEIN KINASE BTK
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00587	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	HUMAN|HGNC=11772|UniProtKB=P36897	TGF-beta receptor type-1	IDA			PTHR23255:SF61	TGF-BETA RECEPTOR TYPE-1
P00057	Wnt signaling pathway	P01444	Wnt	DANRE|ZFIN=ZDB-GENE-980526-249|UniProtKB=Q9I9I2	Protein Wnt	IDA	11266476	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00047	PDGF signaling pathway	P01152	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	8270251	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ARATH|TAIR=AT5G09810|UniProtKB=P53492	Actin-7	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00001	Adrenaline and noradrenaline biosynthesis	P00067	MAO	BOVIN|Ensembl=ENSBTAG00000016206|UniProtKB=P21398	Amine oxidase [flavin-containing] A	ISS	8602220	PubMed	PTHR43563:SF3	AMINE OXIDASE  FLAVIN-CONTAINING  A
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=109485|UniProtKB=Q9WUD6	Protein Wnt-8b	TAS	8717036	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00057	Wnt signaling pathway	P01465	Ggamma	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	IC	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00045	Notch signaling pathway	P01114	Ntm	PANTR|Ensembl=ENSPTRG00000010617|UniProtKB=H2QFL8	Notch 3	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00050	Plasminogen activating cascade	P01249	pro-tPA	MACMU|Ensembl=ENSMMUG00000014432|UniProtKB=F7BHV7	Tissue-type plasminogen activator	ISS	4505861	gi	PTHR44617:SF1	TISSUE-TYPE PLASMINOGEN ACTIVATOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00729	Goalpha	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	IDA	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00944	Actin	RAT|RGD=1309504|UniProtKB=D3ZRN3	Protein Actbl2	ISS	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00047	PDGF signaling pathway	P01168	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04393	Ras Pathway	P04547	Ras	RAT|RGD=2981|UniProtKB=P08644	GTPase KRas	ISS	6287573	PubMed	PTHR24070:SF186	GTPASE KRAS
P00021	FGF signaling pathway	P00627	ERK1-2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	IGI	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=19300|UniProtKB=Q8N4C7	Syntaxin-19	ISS	11067767	PubMed	PTHR19957:SF29	SYNTAXIN-19
P00009	Axon guidance mediated by netrin	P00363	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00020	FAS signaling pathway	P00614	ASK1	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS			PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	DANRE|ZFIN=ZDB-GENE-020604-1|UniProtKB=Q6IQX1	Myosin, heavy polypeptide 2, fast muscle specific	ISS	89264452	PubMed	PTHR13140:SF676	MYOSIN, HEAVY POLYPEPTIDE 2, FAST MUSCLE SPECIFIC
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P02738	De novo purine biosynthesis	P02889	dGDP kinase	HUMAN|HGNC=7852|UniProtKB=O00746	Nucleoside diphosphate kinase, mitochondrial	ISS			PTHR11349:SF49	NUCLEOSIDE DIPHOSPHATE KINASE, MITOCHONDRIAL
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00049	Parkinson disease	P01227	20S proteasome	ORYSJ|EnsemblGenome=OS02G0133800|UniProtKB=P52428	Proteasome subunit alpha type-1	TAS	12859888	PubMed	PTHR11599:SF12	PROTEASOME SUBUNIT ALPHA TYPE-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04393	Ras Pathway	P04570	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	G01581	BAX	DANRE|ZFIN=ZDB-GENE-000511-6|UniProtKB=I3ITC2	Uncharacterized protein	IGI			PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P00059	p53 pathway	P01486	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MACMU|Ensembl=ENSMMUG00000001661|UniProtKB=F7GR69	Uncharacterized protein	ISS	11554554	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00057	Wnt signaling pathway	P01443	Phospholipase C	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DROME|FlyBase=FBgn0000489|UniProtKB=P16912	Protein kinase DC2	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00005	Angiogenesis	P00188	Ets	MACMU|Ensembl=ENSMMUG00000020706|UniProtKB=F6PU72	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P05918	p38 MAPK pathway	P06023	MEF	BOVIN|Ensembl=ENSBTAG00000010649|UniProtKB=A2VDZ3	Myocyte-specific enhancer factor 2A	ISS	11274345	PubMed	PTHR11945:SF256	MYOCYTE-SPECIFIC ENHANCER FACTOR 2A
P00001	Adrenaline and noradrenaline biosynthesis	P00070	VAT2	RAT|RGD=3694|UniProtKB=Q01827	Synaptic vesicular amine transporter	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MACMU|Ensembl=ENSMMUG00000015709|UniProtKB=F6SLX4	Protein Wnt	ISS	14644163	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	TAS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00001	Adrenaline and noradrenaline biosynthesis	P00062	TH	HUMAN|HGNC=11782|UniProtKB=P07101	Tyrosine 3-monooxygenase	ISS	191290	OMIM	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	CANLF|Ensembl=ENSCAFG00000002044|UniProtKB=P63210	Guanine nucleotide-binding protein G(T) subunit gamma-T1	ISS	3100519	PubMed	PTHR13809:SF26	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT GAMMA-T1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00948	Rho	CANLF|Ensembl=ENSCAFG00000029252|UniProtKB=J9P4S7	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF24	RHO-RELATED GTP-BINDING PROTEIN RHOE
P00053	T cell activation	P01312	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05918	p38 MAPK pathway	P06024	eIF4E	HUMAN|HGNC=3287|UniProtKB=P06730	Eukaryotic translation initiation factor 4E	ISS			PTHR11960:SF14	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	TAS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02726	Aminobutyrate degradation	P02825	4-aminobutyrate aminotransferase	MOUSE|MGI=MGI=2443582|UniProtKB=P61922	4-aminobutyrate aminotransferase, mitochondrial	ISS	10989446	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P05913	Enkephalin release	P05978	AC	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P05731	GABA-B receptor II signaling	P05754	Ggamma	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00052	TGF-beta signaling pathway	P01292	RSmads	CANLF|Ensembl=ENSCAFG00000001094|UniProtKB=E2RCX7	Mothers against decapentaplegic homolog	ISS	12736218	PubMed	PTHR13703:SF36	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00010	B cell activation	P00367	NFAT	MACMU|Ensembl=ENSMMUG00000022596|UniProtKB=F6Z7T2	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF5	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 1
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	MONDO|Ensembl=ENSMODG00000011791|UniProtKB=F7CBU9	Phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00029	Huntington disease	P00778	NMDA receptor	MACMU|Ensembl=ENSMMUG00000019112|UniProtKB=F6T8S6	N-methyl D-aspartate receptor subtype 2B	ISS	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CHICK|Ensembl=ENSGALG00000001383|UniProtKB=F1NJL4	Uncharacterized protein	ISS			PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P00019	Endothelin signaling pathway	P00566	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IGI	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	BOVIN|Ensembl=ENSBTAG00000006495|UniProtKB=P11017	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00019	Endothelin signaling pathway	P00591	PLCbeta	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00049	Parkinson disease	P01230	Src kinase	CANLF|Ensembl=ENSCAFG00000007034|UniProtKB=E2RBB8	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00019	Endothelin signaling pathway	P00591	PLCbeta	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00047	PDGF signaling pathway	P01168	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00005	Angiogenesis	P00236	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000011757|UniProtKB=Q9XT97	Presenilin-1	TAS	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	MOUSE|MGI=MGI=104781|UniProtKB=P48542	G protein-activated inward rectifier potassium channel 2	ISS	12374786	PubMed	PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P00018	EGF receptor signaling pathway	P00545	JNK1-3	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IGI	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P02746	Heme biosynthesis	P02982	Protoheme IX farnesyl transferase	HUMAN|HGNC=2260|UniProtKB=Q12887	Protoheme IX farnesyltransferase, mitochondrial	ISS			PTHR43448:SF2	PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL
P00057	Wnt signaling pathway	P01456	beta-arrestin	CAEBR|Gene=CBG08085|UniProtKB=A8X5S0	Protein CBR-ARR-1	ISS	11742073	PubMed	PTHR11792:SF17	KURTZ ARRESTIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	RAT|RGD=2026|UniProtKB=P68035	Actin, alpha cardiac muscle 1	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00056	VEGF signaling pathway	P01425	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	2837282	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00020	FAS signaling pathway	P00615	JNK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00045	Notch signaling pathway	P01107	Fringe	XENTR|Xenbase=XB-GENE-487975|UniProtKB=F6UP69	Beta-1,3-N-acetylglucosaminyltransferase	ISS			PTHR10811:SF7	BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE LUNATIC FRINGE
P02768	Proline biosynthesis	P03114	Glutamyl kinase	SYNY3|EnsemblGenome=BAA17096|UniProtKB=P73071	Glutamate 5-kinase	ISS			PTHR43654:SF2	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8971|UniProtKB=O00443	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MONDO|Ensembl=ENSMODG00000001389|UniProtKB=F7BD45	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF657	MYOSIN-4
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	HUMAN|HGNC=16767|UniProtKB=Q8TCU5	Glutamate receptor ionotropic, NMDA 3A	ISS	11554549	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00021	FGF signaling pathway	P00641	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	XENTR|Xenbase=XB-GENE-489222|UniProtKB=Q28GJ8	Ras homolog gene family, member A	ISS	11360179	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00018	EGF receptor signaling pathway	P00539	14-3-3	DAPPU|EnsemblGenome=DAPPUDRAFT_326737|UniProtKB=E9H8M4	Putative uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00056	VEGF signaling pathway	P01417	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01320	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00807	Actin	BOVIN|Gene=ACTB|UniProtKB=P60712	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P05731	GABA-B receptor II signaling	P05753	Ca channel	HUMAN|HGNC=1389|UniProtKB=Q00975	Voltage-dependent N-type calcium channel subunit alpha-1B	TAS	8386525	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P05734	Synaptic vesicle trafficking	P05773	Munc13	MACMU|Ensembl=ENSMMUG00000016308|UniProtKB=F6TLL7	Uncharacterized protein	ISS	605836	OMIM	PTHR10480:SF8	PROTEIN UNC-13 HOMOLOG B
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	IDA	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00034	Integrin signalling pathway	P00931	Integrin beta	BOVIN|Ensembl=ENSBTAG00000009987|UniProtKB=F1MTN1	Integrin beta	ISS	20069419	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	PANTR|Ensembl=ENSPTRG00000005463|UniProtKB=H2Q6W4	Uncharacterized protein	ISS			PTHR11699:SF233	ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04396	Vitamin D metabolism and pathway	P04606	VDR	MACMU|Ensembl=ENSMMUG00000006727|UniProtKB=F7HFI3	Uncharacterized protein	ISS	11705326	PubMed	PTHR24082:SF38	VITAMIN D3 RECEPTOR
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	MACMU|Ensembl=ENSMMUG00000001731|UniProtKB=F7GN87	Uncharacterized protein	ISS			PTHR10937:SF10	GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE  ISOMERIZING  2
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	ORYSJ|EnsemblGenome=OS10G0563700|UniProtKB=Q7XC37	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	XENTR|Xenbase=XB-GENE-478945|UniProtKB=F6VJF3	Uncharacterized protein	ISS			PTHR11482:SF42	ORNITHINE DECARBOXYLASE
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=3231|UniProtKB=Q9HCU4	Cadherin EGF LAG seven-pass G-type receptor 2	IDA	8120095	PubMed	PTHR24026:SF32	CADHERIN EGF LAG SEVEN-PASS G-TYPE RECEPTOR 2
P00011	Blood coagulation	P00415	Plasmin	HUMAN|HGNC=9071|UniProtKB=P00747	Plasminogen	ISS	2318848	PubMed	PTHR24261:SF6	PLASMINOGEN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	CANLF|Ensembl=ENSCAFG00000010595|UniProtKB=F1PUM1	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF43	REGULATOR OF G-PROTEIN SIGNALING 2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00566	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00059	p53 pathway	P01486	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04542	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	94280860	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01304	Csk	CANLF|Ensembl=ENSCAFG00000017945|UniProtKB=E2RFF7	Tyrosine-protein kinase	ISS	7687537	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00029	Huntington disease	P00807	Actin	NEUCR|EnsemblGenome=EFNCRG00000003893|UniProtKB=P78711	Actin	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04398	p53 pathway feedback loops 2	P04651	Ras	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	IDA	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	CAEBR|Gene=CBG09138|UniProtKB=A8X861	Protein CBR-TBP-1	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04494	TSC2	TAKRU|Ensembl=ENSTRUG00000008958|UniProtKB=H2TCY4	Uncharacterized protein	ISS	15249583	PubMed	PTHR10063:SF0	TUBERIN
P00004	Alzheimer disease-presenilin pathway	P00118	E-cadherin	RAT|RGD=69279|UniProtKB=Q9R0T4	Cadherin-1	IDA	8120095	PubMed	PTHR24027:SF319	CADHERIN-1
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MACMU|Ensembl=ENSMMUG00000010992|UniProtKB=F7GS64	Uncharacterized protein	ISS			PTHR16290:SF5	MRNA-DECAPPING ENZYME 1B
P00054	Toll receptor signaling pathway	P01375	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04398	p53 pathway feedback loops 2	P04657	P110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	RAT|RGD=2733|UniProtKB=P42260	Glutamate receptor ionotropic, kainate 2	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00057	Wnt signaling pathway	P01428	Frizzled	BOVIN|Ensembl=ENSBTAG00000002107|UniProtKB=A7MB15	FZD1 protein	ISS	11212302	PubMed	PTHR11309:SF81	FRIZZLED-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347736|UniProtKB=E9FRT1	Muscle-specific actin	ISS	14684598	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	XENTR|Xenbase=XB-GENE-491938|UniProtKB=Q6DIV8	Actin, alpha 1, skeletal muscle	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	ARATH|TAIR=AT5G61210|UniProtKB=Q9S7P9	SNAP25 homologous protein SNAP33	IC			PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	YEAST|SGD=S000005738|UniProtKB=P18851	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00006	Apoptosis signaling pathway	P00302	ATF	CHICK|Ensembl=ENSGALG00000008494|UniProtKB=Q7SX83	CAMP response element-binding protein	ISS	11390664	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05734	Synaptic vesicle trafficking	P05779	Synaptobrevin	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00018	EGF receptor signaling pathway	P00557	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=104773|UniProtKB=P97718	Alpha-1A adrenergic receptor	IDA			PTHR24248:SF16	ALPHA-1A ADRENERGIC RECEPTOR
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00047	PDGF signaling pathway	P01162	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05734	Synaptic vesicle trafficking	P05770	Munc18	BOVIN|Ensembl=ENSBTAG00000003525|UniProtKB=P61763	Syntaxin-binding protein 1	ISS	8108429	PubMed	PTHR11679:SF35	SYNTAXIN-BINDING PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02744	Fructose galactose metabolism	P02964	Hexose 1-P uridyltransferase	RAT|RGD=1306483|UniProtKB=P43424	Galactose-1-phosphate uridylyltransferase	IDA	1610789	PubMed	PTHR11943:SF1	GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01330	IKK	PANTR|Ensembl=ENSPTRG00000033948|UniProtKB=H2RBD4	Conserved helix-loop-helix ubiquitous kinase	ISS	9346484	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00049	Parkinson disease	P01212	p38 MAPK	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00047	PDGF signaling pathway	P01148	Grb2	DANRE|ZFIN=ZDB-GENE-040426-1975|UniProtKB=Q6PC73	Growth factor receptor-bound protein 2	ISS	4504111	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	CAEEL|WormBase=WBGene00001603|UniProtKB=P34497	Probable glutamine synthetase	ISS			PTHR20852:SF57	GLUTAMINE SYNTHETASE 2 CYTOPLASMIC
P00049	Parkinson disease	P01238	14-3-3	RAT|RGD=3979|UniProtKB=P68255	14-3-3 protein theta	ISS	10407019	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P05730	Endogenous cannabinoid signaling	P05746	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MOUSE|MGI=MGI=102705|UniProtKB=P63213	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IDA	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04542	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05730	Endogenous cannabinoid signaling	P05748	mGluR	CHICK|Ensembl=ENSGALG00000017238|UniProtKB=F1NWG3	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00047	PDGF signaling pathway	P01143	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00187	beta catenin	CANLF|Ensembl=ENSCAFG00000005204|UniProtKB=B6V8E6	Catenin beta-1	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P00047	PDGF signaling pathway	P01150	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IGI	98189216	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00629	PP2A	ARATH|TAIR=AT3G26030|UniProtKB=Q9ZQY6	Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B' delta isoform	ISS			PTHR10257:SF46	SERINE/THREONINE PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B' DELTA ISOFORM-RELATED
P00036	Interleukin signaling pathway	P00990	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MOUSE|MGI=MGI=95819|UniProtKB=P35438	Glutamate receptor ionotropic, NMDA 1	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	14526383	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01284	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01143	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05913	Enkephalin release	P05972	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IDA	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00591	PLCbeta	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04393	Ras Pathway	P04558	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00641	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	2837282	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P02755	Methylmalonyl pathway	P03032	Methylmalonyl-CoA epimerase	HUMAN|HGNC=16732|UniProtKB=Q96PE7	Methylmalonyl-CoA epimerase, mitochondrial	ISS			PTHR43048:SF3	METHYLMALONYL-COA EPIMERASE, MITOCHONDRIAL
P00046	Oxidative stress response	P01131	MKP5	HUMAN|HGNC=18894|UniProtKB=Q8WTR2	Dual specificity protein phosphatase 19	TAS			PTHR10159:SF402	DUAL SPECIFICITY PROTEIN PHOSPHATASE 19
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	MONDO|Ensembl=ENSMODG00000020977|UniProtKB=F6S5B1	Uncharacterized protein (Fragment)	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00057	Wnt signaling pathway	P01456	beta-arrestin	DANRE|ZFIN=ZDB-GENE-060824-1|UniProtKB=C3PTE8	Beta-arrestin 1	ISS	11742073	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00051	TCA cycle	P01266	Pyruvate Dehydrogenase	MOUSE|MGI=MGI=97533|UniProtKB=P35487	Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial	RCA			PTHR11516:SF23	PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA, TESTIS-SPECIFIC FORM, MITOCHONDRIAL
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02748	Isoleucine biosynthesis	P02994	Branched chain amino acid aminotransferase	AQUAE|EnsemblGenome=aq_1893|UniProtKB=O67733	Probable branched-chain-amino-acid aminotransferase	ISS			PTHR42743:SF4	SUBFAMILY NOT NAMED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MACMU|Ensembl=ENSMMUG00000009759|UniProtKB=F6ZIH3	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF504	MYOSIN-13
P04374	5HT2 type receptor mediated signaling pathway	P04413	K+ channel	BOVIN|Ensembl=ENSBTAG00000018193|UniProtKB=E1BHX8	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00059	p53 pathway	P04633	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00805	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DAPPU|EnsemblGenome=DAPPUDRAFT_228751|UniProtKB=E9HGF5	Cytoplasmatic actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	PANTR|Ensembl=ENSPTRG00000007084|UniProtKB=H2Q9G5	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00019	Endothelin signaling pathway	P00590	IP3 R	CAEBR|Gene=CBG_05938|UniProtKB=H8WGV2	Protein CBR-ITR-1, isoform a	ISS	12880387	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IDA			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P02722	Acetate utilization	P02802	Phosphate acetyltransferase	RHOBA|EnsemblGenome=RB9654|UniProtKB=Q7UL90	Phosphate acetyltransferase	ISS			PTHR43356:SF3	PHOSPHATE ACETYLTRANSFERASE
P00005	Angiogenesis	P00254	GTPase	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	ISS	10556059	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00021	FGF signaling pathway	P00642	MEK1-2	DROME|FlyBase=FBgn0010269|UniProtKB=Q24324	Dual specificity mitogen-activated protein kinase kinase dSOR1	ISS	176872	OMIM	PTHR24361:SF629	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	CANLF|Ensembl=ENSCAFG00000012416|UniProtKB=E2RD29	CTP synthase	ISS			PTHR11550:SF2	CTP SYNTHASE 2
P04393	Ras Pathway	P04544	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8316835	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00006	Apoptosis signaling pathway	P00321	HSP70	CAEEL|WormBase=WBGene00002007|UniProtKB=P27420	Heat shock 70 kDa protein C	ISS	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00558	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00029	Huntington disease	P00777	CBP	MOUSE|MGI=MGI=1276116|UniProtKB=B2RWS6	Histone acetyltransferase p300	ISS	10664585	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00005	Angiogenesis	P00188	Ets	HUMAN|HGNC=3488|UniProtKB=P14921	Protein C-ets-1	IDA	15699632	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00045	Notch signaling pathway	P01114	Ntm	MOUSE|MGI=MGI=99460|UniProtKB=Q61982	Neurogenic locus notch homolog protein 3	IC	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00034	Integrin signalling pathway	P00947	Laminin	MACMU|Ensembl=ENSMMUG00000001479|UniProtKB=F7BDD8	Uncharacterized protein	ISS	2538453	PubMed	PTHR10574:SF313	LAMININ SUBUNIT GAMMA-2
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00045	Notch signaling pathway	P01113	Pen-2	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P04374	5HT2 type receptor mediated signaling pathway	P04413	K+ channel	RAT|RGD=61997|UniProtKB=O54912	Potassium channel subfamily K member 3	ISS	15282272	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00008	Axon guidance mediated by Slit/Robo	P00345	Mena	MOUSE|MGI=MGI=108360|UniProtKB=Q03173	Protein enabled homolog	ISS			PTHR11202:SF1	PROTEIN ENABLED HOMOLOG
P00021	FGF signaling pathway	P00644	p38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PLAF7|EnsemblGenome=PFL2215w|UniProtKB=Q8I4X0	Actin-1	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	P01451	Galpha	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	IDA	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00057	Wnt signaling pathway	P01469	Dapper	MOUSE|MGI=MGI=1891740|UniProtKB=Q8R4A3	Dapper homolog 1	IDA	11970895	PubMed	PTHR15919:SF12	DAPPER HOMOLOG 1
P00054	Toll receptor signaling pathway	P01352	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02721	ATP synthesis	P02794	F1 beta	DROME|FlyBase=FBgn0010217|UniProtKB=Q05825	ATP synthase subunit beta, mitochondrial	ISS	2896550	PubMed	PTHR15184:SF44	ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL
P04393	Ras Pathway	P04559	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	10802295	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00034	Integrin signalling pathway	P00928	alpha actinin	MACMU|Ensembl=ENSMMUG00000010767|UniProtKB=F7GV42	Uncharacterized protein	ISS	2116421	PubMed	PTHR43947:SF3	ALPHA-ACTININ-1
P00036	Interleukin signaling pathway	P00990	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IPI	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000019361|UniProtKB=H2QUV3	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000015640|UniProtKB=E2QVF3	Uncharacterized protein	ISS	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00017	DNA replication	P00527	Histones	MACMU|Ensembl=ENSMMUG00000001441|UniProtKB=F7BRX2	Histone H3	ISS	12413958	PubMed	PTHR11426:SF183	HISTONE H3.1
P02776	Serine glycine biosynthesis	P03160	Phosphoglycerate dehydrogenase	CAEEL|WormBase=WBGene00007836|UniProtKB=O17626	Uncharacterized protein	ISS			PTHR42938:SF5	D-3-PHOSPHOGLYCERATE DEHYDROGENASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	TAS	1169551	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00005	Angiogenesis	P00203	Erk	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Gene=CHRM2|UniProtKB=Q9N2A7	Muscarinic acetylcholine receptor M2 (Fragment)	ISS	91373358	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00045	Notch signaling pathway	P01113	Pen-2	MOUSE|MGI=MGI=109284|UniProtKB=Q61144	Presenilin-2	IGI	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P02744	Fructose galactose metabolism	P02963	Ketohexokinase	RAT|RGD=2966|UniProtKB=Q02974	Ketohexokinase	ISS	9799106	PubMed	PTHR43085:SF1	KETOHEXOKINASE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000012922|UniProtKB=H2QJF2	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00054	Toll receptor signaling pathway	P01375	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P02761	Pantothenate biosynthesis	P03069	2-Dehydropantoate reductase	YEAST|SGD=S000002303|UniProtKB=Q07589	Uncharacterized protein YDL144C	ISS			PTHR21708:SF35	SUBFAMILY NOT NAMED
P00010	B cell activation	P00401	jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00018	EGF receptor signaling pathway	P00556	PLCgamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04393	Ras Pathway	P04547	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00005	Angiogenesis	P00203	Erk	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05730	Endogenous cannabinoid signaling	P05751	Galpha	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04649	Myc	HUMAN|HGNC=7553|UniProtKB=P01106	Myc proto-oncogene protein	TAS	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00010	B cell activation	P00371	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04395	Vasopressin synthesis	P04597	Signal Peptide	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000001583|UniProtKB=F7BBM1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	ARATH|TAIR=AT5G07880|UniProtKB=Q9SD96	SNAP25 homologous protein SNAP29	IC			PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	BOVIN|Ensembl=ENSBTAG00000003762|UniProtKB=A5PJS1	GNB5 protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	HUMAN|HGNC=4583|UniProtKB=Q16478	Glutamate receptor ionotropic, kainate 5	ISS	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00034	Integrin signalling pathway	P00925	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00057	Wnt signaling pathway	P01446	Calcineurin	ARATH|TAIR=AT4G01420|UniProtKB=Q7FZF1	Calcineurin B-like protein 5	IDA	12015605	PubMed	PTHR23056:SF44	CALCINEURIN B-LIKE PROTEIN 5
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00053	T cell activation	P01307	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05913	Enkephalin release	P05972	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00047	PDGF signaling pathway	P01145	c-fos	RAT|RGD=2626|UniProtKB=P12841	Proto-oncogene c-Fos	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00003	Alzheimer disease-amyloid secretase pathway	P00081	Pro-BACE-1	MOUSE|MGI=MGI=1346542|UniProtKB=P56818	Beta-secretase 1	IDA	10956649	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	IC	10477300	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00010	B cell activation	P00380	fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	TAS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00046	Oxidative stress response	P01135	p38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	TAS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P02787	Vitamin B6 metabolism	P03244	Pyridoxal kinase	ARATH|TAIR=AT5G37850|UniProtKB=Q8W1X2	Pyridoxal kinase	IDA	11910005	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00976	GSK3	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	IC	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P02738	De novo purine biosynthesis	P02901	Adenosuccinate lyase	SCHMA|EnsemblGenome=Smp_038030|UniProtKB=G4VQX9	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	MACMU|Ensembl=ENSMMUG00000005134|UniProtKB=F7DCC0	Uncharacterized protein	ISS			PTHR42884:SF14	NEUROENDOCRINE CONVERTASE 1
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	HUMAN|HGNC=16767|UniProtKB=Q8TCU5	Glutamate receptor ionotropic, NMDA 3A	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00034	Integrin signalling pathway	P00944	Actin	DANRE|ZFIN=ZDB-GENE-000329-3|UniProtKB=Q7ZVF9	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MACMU|Ensembl=ENSMMUG00000019112|UniProtKB=F6T8S6	N-methyl D-aspartate receptor subtype 2B	ISS	11554554	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00005	Angiogenesis	P00249	PAK	BOVIN|Ensembl=ENSBTAG00000015670|UniProtKB=E1B7J7	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00029	Huntington disease	P00805	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	15737619	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P04398	p53 pathway feedback loops 2	P04657	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00557	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	12660731	PubMed	PTHR10048:SF14	PI-3 KINASE
P02723	Adenine and hypoxanthine salvage pathway	P02813	Inosine phosphorylase	THEMA|EnsemblGenome=TM_1596|UniProtKB=Q9X1T2	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IGI	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MOUSE|MGI=MGI=102522|UniProtKB=Q8R3Z5	Voltage-dependent L-type calcium channel subunit beta-1	IC	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000011838|UniProtKB=H2QHR7	Serine/threonine-protein kinase	ISS	12676944	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P02783	Tryptophan biosynthesis	P03209	Anthranilate phosphoribosyl transferase	RHOBA|EnsemblGenome=RB410|UniProtKB=Q7UYS5	Anthranilate phosphoribosyltransferase	ISS			PTHR43285:SF2	ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	STRPU|EnsemblGenome=SPU_018419|UniProtKB=W4YRI6	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00941	Integrin alpha	CAEEL|WormBase=WBGene00002081|UniProtKB=Q03600	Integrin alpha ina-1	IPI	3487386	PubMed	PTHR23220:SF121	INTEGRIN ALPHA INA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00010	B cell activation	P00398	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	1718748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IDA	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	IEA			PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05730	Endogenous cannabinoid signaling	P05743	CB1	PANTR|Ensembl=ENSPTRG00000018411|UniProtKB=Q5IS73	Cannabinoid receptor 1	ISS	9888857	PubMed	PTHR22750:SF47	CANNABINOID RECEPTOR 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000012922|UniProtKB=H2QJF2	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00057	Wnt signaling pathway	P01438	PP2A	MOUSE|MGI=MGI=2388481|UniProtKB=Q91V89	Protein Ppp2r5d	ISS	12110603	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00865	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	7798194	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00021	FGF signaling pathway	P00646	RasGAP	HUMAN|HGNC=9871|UniProtKB=P20936	Ras GTPase-activating protein 1	IGI	11847220	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00819	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00470	F-actin	HUMAN|HGNC=17780|UniProtKB=Q562R1	Beta-actin-like protein 2	IC	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	TAS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IDA	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00011	Blood coagulation	P00460	FXI	PANTR|Gene=F9|UniProtKB=Q95ND7	Coagulation factor IX	ISS	14270123	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P00034	Integrin signalling pathway	P00922	Collagen	BOVIN|Gene=COL10A1|UniProtKB=P23206	Collagen alpha-1(X) chain	IDA	10778855	PubMed	PTHR44057:SF5	COLLAGEN ALPHA-1 X  CHAIN
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	PANTR|Ensembl=ENSPTRG00000008123|UniProtKB=H2QB41	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF29	72 KDA TYPE IV COLLAGENASE
P02781	Threonine biosynthesis	P03189	Aspartate kinase	ECOLI|EcoGene=EG10550|UniProtKB=P08660	Lysine-sensitive aspartokinase 3	ISS			PTHR21499:SF38	ASPARTOKINASE 1, CHLOROPLASTIC
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00747	Rhodopsin	ANOGA|EnsemblGenome=AGAP001162|UniProtKB=A0NH90	AGAP001162-PA	ISS	1634520	PubMed	PTHR24240:SF85	OPSIN RH1-RELATED
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	DANRE|ZFIN=ZDB-GENE-030407-2|UniProtKB=F8W5D0	Uncharacterized protein (Fragment)	ISS			PTHR11681:SF13	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00780	Microtubule	MOUSE|MGI=MGI=1915201|UniProtKB=Q922F4	Tubulin beta-6 chain	IDA	9454836	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CHICK|Gene=JUN|UniProtKB=P18870	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P02738	De novo purine biosynthesis	P02902	ADP reductase	ECOLI|EcoGene=EG10661|UniProtKB=P69924	Ribonucleoside-diphosphate reductase 1 subunit beta	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P06216	SCW signaling pathway	P06331	MAD	DROME|FlyBase=FBgn0011648|UniProtKB=P42003	Protein mothers against dpp	IGI	12736218	PubMed	PTHR13703:SF40	PROTEIN MOTHERS AGAINST DPP
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	MACMU|Ensembl=ENSMMUG00000020765|UniProtKB=F7HEG5	Ribonucleoside-diphosphate reductase subunit M2 B	ISS			PTHR23409:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 B
P00029	Huntington disease	G01530	HTT	RAT|RGD=68337|UniProtKB=P51111	Huntingtin	IDA	7620118	PubMed	PTHR10170:SF10	HUNTINGTIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00729	Goalpha	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00045	Notch signaling pathway	P01101	Su(H)	MOUSE|MGI=MGI=1196616|UniProtKB=O08674	Recombining binding protein suppressor of hairless-like protein	TAS	12681948	PubMed	PTHR10665:SF2	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS-LIKE PROTEIN
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	PANTR|Ensembl=ENSPTRG00000017974|UniProtKB=H2QSN4	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00029	Huntington disease	P00805	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	CHICK|Ensembl=ENSGALG00000011558|UniProtKB=F1NWV6	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	TAS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	TAS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00006	Apoptosis signaling pathway	P00274	JNK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	ISS	11707292	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00627	ERK1-2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01211	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	RAT|RGD=2916|UniProtKB=P01323	Insulin-2	ISS			PTHR11454:SF29	INSULIN-2
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	MONDO|Ensembl=ENSMODG00000014177|UniProtKB=F6U7A6	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00008	Axon guidance mediated by Slit/Robo	P00355	Rho	SCHPO|PomBase=SPAC20H4.11c|UniProtKB=Q9HE04	GTP-binding protein rho5	ISS	11973360	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01087	CAT	CAEBR|Gene=CBG08305|UniProtKB=A8X694	Protein CBR-CHA-1	ISS	97225904	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	HUMAN|HGNC=4584|UniProtKB=Q05586	Glutamate receptor ionotropic, NMDA 1	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00805	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00645	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00025	Hedgehog signaling pathway	P00691	CBP	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	176910	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	TAKRU|Ensembl=ENSTRUG00000011517|UniProtKB=H2TWL9	Uncharacterized protein (Fragment)	ISS	10331083	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00047	PDGF signaling pathway	P01150	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g234494|UniProtKB=A7RU31	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TAKRU|Ensembl=ENSTRUG00000007989|UniProtKB=P68140	Actin, alpha skeletal muscle A	ISS	11889139	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00021	FGF signaling pathway	P00647	SHP2	PANTR|Ensembl=ENSPTRG00000042397|UniProtKB=H2RIH8	Tyrosine-protein phosphatase non-receptor type	ISS	7681589	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	RAT|RGD=1560525|UniProtKB=Q498S8	Frizzled-8	ISS	8717036	PubMed	PTHR11309:SF90	FRIZZLED-8
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00049	Parkinson disease	P01227	20S proteasome	DANRE|ZFIN=ZDB-GENE-001208-4|UniProtKB=F1Q5N4	Proteasome subunit beta type	TAS	12859888	PubMed	PTHR11599:SF42	PROTEASOME SUBUNIT BETA TYPE-7
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	HUMAN|HGNC=4595|UniProtKB=Q14832	Metabotropic glutamate receptor 3	ISS	12351712	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00053	T cell activation	P01307	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00036	Interleukin signaling pathway	P00965	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00805	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00260	AKT	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05730	Endogenous cannabinoid signaling	P05751	Galpha	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00206	Wnt	CIOIN|Ensembl=ENSCING00000000407|UniProtKB=Q9U6V0	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF77	PROTEIN WNT-5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MACMU|Ensembl=ENSMMUG00000009759|UniProtKB=F6ZIH3	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF504	MYOSIN-13
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	CRYNJ|EnsemblGenome=CND03830|UniProtKB=Q5KI86	Uncharacterized protein	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	TAS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DANRE|ZFIN=ZDB-GENE-050417-59|UniProtKB=Q15KE4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00056	VEGF signaling pathway	P01417	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	ARATH|TAIR=AT2G44680|UniProtKB=O80507	Putative casein kinase II subunit beta-4	IDA	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	CANLF|Ensembl=ENSCAFG00000011733|UniProtKB=E2R5J6	Protein-serine/threonine kinase	ISS	10852916	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	TAS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00049	Parkinson disease	P01236	Casein kinase II	RAT|RGD=1306882|UniProtKB=B4F7A9	Casein kinase 2, alpha prime polypeptide	ISS	10806215	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	CHICK|Ensembl=ENSGALG00000006910|UniProtKB=F1N808	Uncharacterized protein	ISS			PTHR11911:SF121	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2
P02788	Xanthine and guanine salvage pathway	P03247	Xanthine phosphoribosyl transferase	DEIRA|EnsemblGenome=DR_1376|UniProtKB=Q9RUK8	Hypoxanthine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00052	TGF-beta signaling pathway	P01284	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00006	Apoptosis signaling pathway	P00260	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05755	Gbeta	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P02723	Adenine and hypoxanthine salvage pathway	P02810	Adenine phosphoribosyl transferase	HUMAN|HGNC=626|UniProtKB=P07741	Adenine phosphoribosyltransferase	ISS			PTHR32315:SF3	ADENINE PHOSPHORIBOSYLTRANSFERASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	RCA	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	RAT|RGD=621060|UniProtKB=O88777	Presenilin-2	TAS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00034	Integrin signalling pathway	P00912	Arp2/3	CAEEL|WormBase=WBGene00000205|UniProtKB=O61861	Actin-related protein 2/3 complex subunit 5	IPI	12473693	PubMed	PTHR12644:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P02748	Isoleucine biosynthesis	P02997	Acetolactate synthase	BACSU|EnsemblGenome=BSU36010|UniProtKB=Q04789	Acetolactate synthase	ISS			PTHR18968:SF129	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04456	ProCRF (Pro Corticotropin-Releasing Factor)	DANRE|ZFIN=ZDB-GENE-041114-75|UniProtKB=A7LNS7	Corticotropin releasing factor	ISS	122560	OMIM	PTHR15035:SF9	CORTICOLIBERIN
P00047	PDGF signaling pathway	P01142	p90RSK	ORNAN|Ensembl=ENSOANG00000010658|UniProtKB=F6V2V1	Uncharacterized protein	ISS	10558991	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00034	Integrin signalling pathway	P00941	Integrin alpha	RAT|Ensembl=ENSRNOG00000058111|UniProtKB=A0A0G2K470	Protein Itga2	ISS	10727440	PubMed	PTHR23220:SF23	INTEGRIN ALPHA-2
P04393	Ras Pathway	P04570	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	BOVIN|Ensembl=ENSBTAG00000002081|UniProtKB=A7YWG6	Serine/threonine-protein kinase receptor	ISS	10683140	PubMed	PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P00047	PDGF signaling pathway	P01159	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MONDO|Gene=KRAS|UniProtKB=Q07983	GTPase KRas	ISS	9869449	PubMed	PTHR24070:SF186	GTPASE KRAS
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00128	Erb-B4	PANTR|Ensembl=ENSPTRG00000012883|UniProtKB=H2QJC5	Receptor protein-tyrosine kinase	ISS	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	HALSA|EnsemblGenome=AAC82884|UniProtKB=O52004	TATA-box-binding protein C	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00206	Wnt	PANTR|Ensembl=ENSPTRG00000019617|UniProtKB=Q2QLE7	Protein Wnt-2	ISS	8717036	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00021	FGF signaling pathway	P00642	MEK1-2	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	CHICK|Ensembl=ENSGALG00000011128|UniProtKB=E1C6N0	Uncharacterized protein	ISS	9727008	PubMed	PTHR10410:SF5	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 14
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	11035810	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00053	T cell activation	P01312	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00006	Apoptosis signaling pathway	P00274	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00038	JAK/STAT signaling pathway	P01034	Jak	HUMAN|HGNC=6192|UniProtKB=O60674	Tyrosine-protein kinase JAK2	ISS	22482294	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00037	Ionotropic glutamate receptor pathway	P01023	CaMKII	DANRE|ZFIN=ZDB-GENE-040801-121|UniProtKB=Q6DEH3	Calcium/calmodulin-dependent protein kinase type II delta 1 chain	ISS	12888804	PubMed	PTHR43940:SF4	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT DELTA
P05916	Opioid prodynorphin pathway	P06002	G-protein	XENTR|Xenbase=XB-GENE-969601|UniProtKB=Q28H40	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00029	Huntington disease	P00807	Actin	ORYSJ|EnsemblGenome=OS12G0163700|UniProtKB=Q0IPW3	Os12g0163700 protein	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00047	PDGF signaling pathway	P01152	RasGAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	CANLF|Ensembl=ENSCAFG00000012923|UniProtKB=F1PEK4	Uncharacterized protein	ISS			PTHR44107:SF3	DOWN SYNDROME CELL ADHESION MOLECULE-LIKE PROTEIN 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06768	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	RCA	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	BOVIN|Ensembl=ENSBTAG00000030182|UniProtKB=G3X793	Mitogen-activated protein kinase	ISS	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MOUSE|MGI=MGI=2150393|UniProtKB=Q91ZU9	Glutamate receptor ionotropic, NMDA 3B	ISS	14698601	PubMed	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05913	Enkephalin release	P05976	Enkephalin	RAT|RGD=62054|UniProtKB=P06300	Proenkephalin-B	ISS	131330	OMIM	PTHR11438:SF4	PROENKEPHALIN-B
P00036	Interleukin signaling pathway	P00990	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00054	Toll receptor signaling pathway	P01375	JNK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000022175|UniProtKB=F6XHY0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Ensembl=ENSCAFG00000007780|UniProtKB=F1PZH9	Uncharacterized protein	ISS	12441358	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MOUSE|MGI=MGI=2444552|UniProtKB=Q8BFZ3	Beta-actin-like protein 2	ISS	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00021	FGF signaling pathway	P00633	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P06959	CCKR signaling map	G06992	ACAT1	HUMAN|HGNC=93|UniProtKB=P24752	Acetyl-CoA acetyltransferase, mitochondrial	RCA		PubMed	PTHR18919:SF81	ACETYL-COA ACETYLTRANSFERASE, MITOCHONDRIAL
P02762	Pentose phosphate pathway	P03072	Ribitol Dehydrogenase	ARATH|TAIR=AT5G50130|UniProtKB=Q8RWK2	Ribitol dehydrogenase-like	ISS	10177224	gi	PTHR24320:SF120	RIBITOL DEHYDROGENASE-LIKE
P00011	Blood coagulation	P00422	FIXa	PANTR|Gene=F9|UniProtKB=Q95ND7	Coagulation factor IX	ISS	14270123	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=98959|UniProtKB=P22726	Protein Wnt-5b	IDA	8717036	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00048	PI3 kinase pathway	P01202	p85	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	RAT|RGD=1310096|UniProtKB=B2RZ72	Actin-related protein 2/3 complex subunit 4	ISS	9230079	PubMed	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00049	Parkinson disease	P01211	ERK	RAT|RGD=628675|UniProtKB=Q9Z2A6	Mitogen-activated protein kinase 15	IDA	9891064	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IDA	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00223	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00557	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ENTHI|EnsemblGenome=EHI_107290|UniProtKB=B1N2P0	Actin	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00034	Integrin signalling pathway	P00941	Integrin alpha	BOVIN|Ensembl=ENSBTAG00000007602|UniProtKB=E1BNM2	Uncharacterized protein	ISS	3487386	PubMed	PTHR23220:SF5	INTEGRIN ALPHA-8
P00005	Angiogenesis	P00236	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	MACMU|Ensembl=ENSMMUG00000005432|UniProtKB=F7GQ56	Clathrin heavy chain	ISS	9388255	PubMed	PTHR10292:SF6	CLATHRIN HEAVY CHAIN 2
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	PANTR|Ensembl=ENSPTRG00000006342|UniProtKB=H2Q8A8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	MOUSE|MGI=MGI=107471|UniProtKB=P31695	Neurogenic locus notch homolog protein 4	IDA	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CANLF|Ensembl=ENSCAFG00000008756|UniProtKB=F2Z4N8	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	RCA	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00021	FGF signaling pathway	P00643	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01320	PLC-gamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00034	Integrin signalling pathway	P00931	Integrin beta	BOVIN|Ensembl=ENSBTAG00000009987|UniProtKB=F1MTN1	Integrin beta	ISS	280842	gi	PTHR10082:SF25	INTEGRIN BETA-3
P02730	Asparagine and aspartate biosynthesis	P02853	Asparagine synthetase	CAEBR|Gene=CBG01494|UniProtKB=A8WQK1	Protein CBR-ASNS-1	ISS			PTHR11772:SF35	ASPARAGINE SYNTHETASE
P00030	Hypoxia response via HIF activation	P00824	PTEN	HUMAN|HGNC=12023|UniProtKB=P56180	Putative tyrosine-protein phosphatase TPTE	TAS			PTHR12305:SF32	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE TPTE2-RELATED
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CHICK|Ensembl=ENSGALG00000006638|UniProtKB=R4GGL9	Uncharacterized protein	ISS	1648176	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00048	PI3 kinase pathway	P01189	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00007	Axon guidance mediated by semaphorins	P00340	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00018	EGF receptor signaling pathway	P00557	PI3K	CAEEL|WormBase=WBGene00009552|UniProtKB=G5EDY0	Phosphatidylinositol 3-kinase piki-1	ISS	7937853	PubMed	PTHR10048:SF64	LD28067P
P00047	PDGF signaling pathway	P01148	Grb2	MACMU|Ensembl=ENSMMUG00000005327|UniProtKB=F7GJG7	GRB2-related adapter protein	ISS	51702266	gi	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CAEEL|WormBase=WBGene00000951|UniProtKB=P54244	Acetylcholine receptor subunit alpha-type deg-3	IC			PTHR18945:SF472	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-TYPE DEG-3
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00235	c-Fos	PANTR|Ensembl=ENSPTRG00000006553|UniProtKB=A5A6H0	C-fos	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00019	Endothelin signaling pathway	P00590	IP3 R	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01162	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01438	PP2A	BRAFL|Gene=BRAFLDRAFT_123893|UniProtKB=C3XQF4	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000010195|UniProtKB=E1B7J3	Uncharacterized protein	ISS	10644715	PubMed	PTHR24356:SF175	SERINE/THREONINE-PROTEIN KINASE N3
P00057	Wnt signaling pathway	P01443	Phospholipase C	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	IDA	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00047	PDGF signaling pathway	P01153	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MONDO|Ensembl=ENSMODG00000018204|UniProtKB=F6PGX6	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	MOUSE|MGI=MGI=2444259|UniProtKB=Q8C6K9	Collagen alpha-6(VI) chain	IC	10778855	PubMed	PTHR44105:SF3	COLLAGEN ALPHA-6 VI  CHAIN
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01211	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	97449291	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04397	p53 pathway by glucose deprivation	P04641	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00019	Endothelin signaling pathway	P00570	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	176892	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DROME|FlyBase=FBgn0014011|UniProtKB=P48554	Ras-related protein Rac2	ISS	12932731	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00059	p53 pathway	G01571	FAS	PANTR|Ensembl=ENSPTRG00000002730|UniProtKB=H2R2U8	Fas (TNF receptor superfamily, member 6)	ISS			PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	HUMAN|HGNC=1077|UniProtKB=O00238	Bone morphogenetic protein receptor type-1B	TAS	9395284	PubMed	PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00010	B cell activation	P00373	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00047	PDGF signaling pathway	P01161	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04393	Ras Pathway	P04557	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	RAT|RGD=2344|UniProtKB=P08485	Muscarinic acetylcholine receptor M4	ISS	8100450	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00010	B cell activation	P00371	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	RAT|RGD=2746|UniProtKB=P31424	Metabotropic glutamate receptor 5	ISS	12488551	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00006	Apoptosis signaling pathway	P00269	MAPK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00029	Huntington disease	P00780	Microtubule	ORYSJ|EnsemblGenome=OS01G0282800|UniProtKB=Q43594	Tubulin beta-1 chain	IDA	12932731	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00565	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P04398	p53 pathway feedback loops 2	P04651	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00018	EGF receptor signaling pathway	P00557	PI3K	ANOGA|EnsemblGenome=AGAP011036|UniProtKB=A0NBA9	AGAP011036-PA (Fragment)	ISS	7937853	PubMed	PTHR10048:SF64	LD28067P
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	TAS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000014751|UniProtKB=H2R8D8	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00627	ERK1-2	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00012	Cadherin signaling pathway	P00475	Frizzled	XENTR|Xenbase=XB-GENE-479707|UniProtKB=F6QAW3	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF126	FRIZZLED-5
P00046	Oxidative stress response	P01135	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	TAS	12810719	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04393	Ras Pathway	P04574	PLD	PANTR|Ensembl=ENSPTRG00000015626|UniProtKB=H2R1L6	Phospholipase D1, phosphatidylcholine-specific	ISS	15668389	PubMed	PTHR18896:SF57	PHOSPHOLIPASE D1
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	IC	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CAEBR|Gene=CBG03476|UniProtKB=A8WV58	Protein CBR-EGL-20	ISS	8717036	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	IDA	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00543	ERK1-2	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IGI	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00054	Toll receptor signaling pathway	P01354	NFkappaB	HUMAN|HGNC=7795|UniProtKB=Q00653	Nuclear factor NF-kappa-B p100 subunit	ISS	12574369	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	91298951	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00114	actin	YEAST|SGD=S000001855|UniProtKB=P60010	Actin	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MACMU|Ensembl=ENSMMUG00000004886|UniProtKB=F7AGT9	Uncharacterized protein	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00049	Parkinson disease	P01208	Hsp70	LEPIN|EnsemblGenome=LA_3705|UniProtKB=P61443	Chaperone protein DnaK	IDA	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P00029	Huntington disease	P00788	Calpain	HUMAN|HGNC=1481|UniProtKB=P04632	Calpain small subunit 1	ISS	11675509	PubMed	PTHR44408:SF3	CALPAIN SMALL SUBUNIT 1
P00006	Apoptosis signaling pathway	P00310	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	12660731	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	NAS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CHICK|Ensembl=ENSGALG00000015835|UniProtKB=F1NZT2	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=4596|UniProtKB=Q14833	Metabotropic glutamate receptor 4	IDA	12488551	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00048	PI3 kinase pathway	P01192	p110	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000008189|UniProtKB=H2QB91	Cadherin 11, type 2, OB-cadherin (Osteoblast)	ISS	8120095	PubMed	PTHR24027:SF85	CADHERIN-11
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00010	B cell activation	P00379	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04398	p53 pathway feedback loops 2	P04669	ATM	HUMAN|HGNC=795|UniProtKB=Q13315	Serine-protein kinase ATM	TAS	10196661	PubMed	PTHR11139:SF72	SERINE-PROTEIN KINASE ATM
P00057	Wnt signaling pathway	P01435	SWI/SNF	HUMAN|HGNC=11108|UniProtKB=Q6STE5	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3	IDA	11532957	PubMed	PTHR13844:SF5	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D MEMBER 3
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	TAS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01465	Ggamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00005	Angiogenesis	P00236	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	ISS	10188796	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05913	Enkephalin release	P05972	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05939	GRK6	RAT|RGD=61986|UniProtKB=P97711	G protein-coupled receptor kinase 6	RCA	12032308	PubMed	PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04397	p53 pathway by glucose deprivation	P04641	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P06959	CCKR signaling map	G07270	PAI2	HUMAN|HGNC=8584|UniProtKB=P05120	Plasminogen activator inhibitor 2	RCA	12105855	PubMed	PTHR11461:SF61	PLASMINOGEN ACTIVATOR INHIBITOR 2
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	G04671	proopiomelanocortin	HUMAN|HGNC=9201|UniProtKB=P01189	Pro-opiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	ARATH|TAIR=AT2G29900|UniProtKB=Q9SIK7	Presenilin-like protein At2g29900	TAS	8755489	PubMed	PTHR10202:SF22	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04559	Rac	ORYSJ|EnsemblGenome=OS02G0834000|UniProtKB=Q6EP31	Rac-like GTP-binding protein 5	ISS	20318363	PubMed	PTHR24072:SF194	RAC-LIKE GTP-BINDING PROTEIN ARAC4-RELATED
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00056	VEGF signaling pathway	P01411	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00010	B cell activation	P00369	MEKK	PANTR|Ensembl=ENSPTRG00000009518|UniProtKB=H2QDN0	Mitogen-activated protein kinase kinase kinase 3	ISS	9006902	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00056	VEGF signaling pathway	P01403	VEGFR-2	DANRE|ZFIN=ZDB-GENE-000705-1|UniProtKB=Q8AXB3	Vascular endothelial growth factor receptor kdr-like	ISS			PTHR24416:SF500	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR KDR-LIKE
P00046	Oxidative stress response	P01136	Elk-1	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	9644975	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00020	FAS signaling pathway	P00615	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00006	Apoptosis signaling pathway	P00269	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	13430383	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00020	FAS signaling pathway	P00604	Pro-Caspase8	CHICK|Ensembl=ENSGALG00000008355|UniProtKB=F1NXP6	Uncharacterized protein	IGI	8681376	PubMed	PTHR10454:SF162	CASPASE-8
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	HALSA|EnsemblGenome=VNG_2243G|UniProtKB=Q9HN56	TATA-box-binding protein E	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00057	Wnt signaling pathway	P01448	CBP	CAEEL|WormBase=WBGene00010545|UniProtKB=G5EBG3	CBP/p300 homolog	ISS	10823891	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00048	PI3 kinase pathway	P01192	p110	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01438	PP2A	RAT|RGD=3381|UniProtKB=P62716	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04384	Gamma-aminobutyric acid synthesis	P04481	Succinic semialdehyde dehydrogenase	RAT|RGD=621422|UniProtKB=P51650	Succinate-semialdehyde dehydrogenase, mitochondrial	IC	12891648	PubMed	PTHR43353:SF5	SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	IDA	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00029	Huntington disease	P00786	ARF	PRIPA|Gene=PPA11732|UniProtKB=H3EPN0	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00059	p53 pathway	P01485	p53	HUMAN|HGNC=12003|UniProtKB=O15350	Tumor protein p73	TAS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P05913	Enkephalin release	P05974	G-Protein (i)	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00022	General transcription by RNA polymerase I	P00650	TAF-IB	CAEEL|WormBase=WBGene00006390|UniProtKB=Q7YTH5	TAF (TBP-associated transcription factor) family	ISS			PTHR12321:SF78	TAF  TBP-ASSOCIATED TRANSCRIPTION FACTOR  FAMILY
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00023	General transcription regulation	P00666	TFIIE	DROME|FlyBase=FBgn0015828|UniProtKB=O96880	GH11150p	ISS			PTHR13097:SF7	NOVEL PROTEIN SIMILAR TO VERTEBRATE GENERAL TRANSCRIPTION FACTOR IIE POLYPEPTIDE 1 ALPHA 56KDA  GTF2E1
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P01486	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	RAT|RGD=620241|UniProtKB=Q9QXN1	Lymphoid enhancer-binding factor 1	TAS	11266476	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00049	Parkinson disease	P01211	ERK	TRYB2|Gene=Tb10.6k15.2790|UniProtKB=Q38AI6	Mitogen-activated protein kinase	ISS			PTHR24055:SF178	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04559	Rac	ORYSJ|EnsemblGenome=OS02G0120800|UniProtKB=Q6ZHA3	Rac-like GTP-binding protein 6	ISS	11950993	PubMed	PTHR24072:SF261	SUBFAMILY NOT NAMED
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	BOVIN|Ensembl=ENSBTAG00000009269|UniProtKB=F1MCM2	Uncharacterized protein	ISS	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	IC	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00048	PI3 kinase pathway	G01546	Cyclin d	MOUSE|MGI=MGI=88314|UniProtKB=P30280	G1/S-specific cyclin-D2	ISS			PTHR10177:SF66	G1/S-SPECIFIC CYCLIN-D2
P00034	Integrin signalling pathway	P00919	Arf6	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g166872|UniProtKB=A7S615	Predicted protein	ISS	12932731	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P02729	Ascorbate degradation	P02849	L-xylulose kinase	BOVIN|Ensembl=ENSBTAG00000011278|UniProtKB=Q3SYZ6	Xylulose kinase	ISS			PTHR10196:SF57	XYLULOSE KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00642	MEK1-2	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00552	Ras	HUMAN|HGNC=17271|UniProtKB=P62070	Ras-related protein R-Ras2	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00012	Cadherin signaling pathway	P00470	F-actin	LEIMA|EnsemblGenome=LmjF.04.1230|UniProtKB=Q9U1E8	Actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04431	5HT transporter	MACMU|Gene=SLC6A4|UniProtKB=Q9MYX0	Sodium-dependent serotonin transporter	ISS	7681602	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	CANLF|Ensembl=ENSCAFG00000017516|UniProtKB=E2REK6	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF311	CALMODULIN
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00053	T cell activation	P01297	MEKK	RAT|RGD=620966|UniProtKB=Q62925	Mitogen-activated protein kinase kinase kinase 1	RCA	8940199	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00021	FGF signaling pathway	P00642	MEK1-2	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CHICK|Ensembl=ENSGALG00000009844|UniProtKB=P68034	Actin, alpha cardiac muscle 1	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	BOVIN|Ensembl=ENSBTAG00000018270|UniProtKB=F1MGR9	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00015	Circadian clock system	P00506	BMAL1	PANTR|Ensembl=ENSPTRG00000003376|UniProtKB=H2R2H7	Uncharacterized protein	ISS	11163178	PubMed	PTHR23042:SF52	ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 1
P02725	Allantoin degradation	P02821	Allantoate amidohydrolase	MOUSE|MGI=MGI=2136971|UniProtKB=Q9JHX6	Probable allantoicase	ISS			PTHR12045:SF3	ALLANTOICASE-RELATED
P00053	T cell activation	P01332	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IDA	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00736	CalDAG-GEF	MACMU|Ensembl=ENSMMUG00000020469|UniProtKB=F6VRK5	Uncharacterized protein	ISS	10835426	PubMed	PTHR23113:SF157	RAS GUANYL-RELEASING PROTEIN 4
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	HUMAN|HGNC=4597|UniProtKB=P41594	Metabotropic glutamate receptor 5	ISS	12351712	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P05913	Enkephalin release	P05974	G-Protein (i)	TAKRU|Ensembl=ENSTRUG00000007253|UniProtKB=H2SZQ1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00036	Interleukin signaling pathway	P00981	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00006	Apoptosis signaling pathway	P00317	Fos	PANTR|Ensembl=ENSPTRG00000006553|UniProtKB=A5A6H0	C-fos	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00005	Angiogenesis	P00206	Wnt	PANTR|Ensembl=ENSPTRG00000004519|UniProtKB=H2Q569	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00001	Adrenaline and noradrenaline biosynthesis	P00066	DOPA decarb.	CAEEL|WormBase=WBGene00000239|UniProtKB=O45137	Biogenic Amine Synthesis related	ISS	7567987	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P05916	Opioid prodynorphin pathway	P06002	G-protein	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P05918	p38 MAPK pathway	P06013	ELK	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	RCA	11279280	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00021	FGF signaling pathway	P00645	Rac	ENTHI|EnsemblGenome=EHI_129750|UniProtKB=C4M5Q7	Rho family GTPase	IGI	98264868	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02738	De novo purine biosynthesis	P02907	dADP kinase	TRYB2|Gene=Tb11.01.7800|UniProtKB=Q381H3	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00057	Wnt signaling pathway	P01438	PP2A	MONDO|Ensembl=ENSMODG00000019001|UniProtKB=F7CP86	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01311	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04559	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MONDO|Ensembl=ENSMODG00000020977|UniProtKB=F6S5B1	Uncharacterized protein (Fragment)	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	MACMU|Ensembl=ENSMMUG00000011442|UniProtKB=F7B9T3	Ras-related protein Rap-1b	ISS	8576107	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00006	Apoptosis signaling pathway	P00310	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01451	Galpha	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01177	P110ACT	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	DANRE|ZFIN=ZDB-GENE-030131-7741|UniProtKB=Q6PE34	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF93	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00623	FGF	PANTR|Ensembl=ENSPTRG00000007057|UniProtKB=H2Q9E4	Fibroblast growth factor	ISS			PTHR11486:SF20	FIBROBLAST GROWTH FACTOR 7
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	DANRE|ZFIN=ZDB-GENE-030131-6129|UniProtKB=F1QR17	Uncharacterized protein	ISS			PTHR43521:SF1	ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00018	EGF receptor signaling pathway	P00564	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	HUMAN|HGNC=6698|UniProtKB=O75581	Low-density lipoprotein receptor-related protein 6	IDA	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00056	VEGF signaling pathway	P01418	Paxillin	HUMAN|HGNC=9718|UniProtKB=P49023	Paxillin	ISS	7579684	PubMed	PTHR24216:SF11	PAXILLIN
P02721	ATP synthesis	P02791	F1 alpha	MOUSE|MGI=MGI=88115|UniProtKB=Q03265	ATP synthase subunit alpha, mitochondrial	ISS	11479684	PubMed	PTHR43089:SF3	ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	PHYPA|Gene=PHYPADRAFT_164900|UniProtKB=A9SHI2	Predicted protein	ISS			PTHR23073:SF8	26S PROTEASE REGULATORY SUBUNIT 6B
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00052	TGF-beta signaling pathway	P01292	RSmads	MOUSE|MGI=MGI=1859993|UniProtKB=Q9JIW5	Mothers against decapentaplegic homolog 9	TAS	9395284	PubMed	PTHR13703:SF41	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 9
P00024	Glycolysis	P00678	Enolase	BOVIN|Ensembl=ENSBTAG00000011274|UniProtKB=A6QR19	ENO2 protein	ISS	5803011	gi	PTHR11902:SF10	GAMMA-ENOLASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01307	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00057	Wnt signaling pathway	P01443	Phospholipase C	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IDA	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00030	Hypoxia response via HIF activation	P00819	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	RAT|RGD=2025|UniProtKB=P68136	Actin, alpha skeletal muscle	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000012820|UniProtKB=F1MDL3	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00034	Integrin signalling pathway	P00938	Cdc42	TAKRU|Ensembl=ENSTRUG00000013411|UniProtKB=H2UB84	Uncharacterized protein	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF31	SUBFAMILY NOT NAMED
P00010	B cell activation	P00402	Jnk	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00010	B cell activation	P00379	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	SCHPO|PomBase=SPAC1F3.02c|UniProtKB=Q10407	MAP kinase kinase kinase mkh1	ISS			PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00019	Endothelin signaling pathway	P00566	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02738	De novo purine biosynthesis	P02909	GDP reductase	ORNAN|Ensembl=ENSOANG00000010680|UniProtKB=F6U4A0	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P02738	De novo purine biosynthesis	P02911	N5-carboxyaminoimidazole ribonucleotide mutase	BACTN|EnsemblGenome=BT_2518|UniProtKB=Q8A4S9	N5-carboxyaminoimidazole ribonucleotide mutase	ISS			PTHR23046:SF2	N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE MUTASE
P00053	T cell activation	P01300	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00018	EGF receptor signaling pathway	P00557	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01193	IRS	CANLF|Ensembl=ENSCAFG00000010397|UniProtKB=E2RDB5	Uncharacterized protein	ISS	5031805	gi	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P02778	Sulfate assimilation	P03167	Sulfate adenylyltransferase	ENTHI|EnsemblGenome=EHI_197160|UniProtKB=C4LVD3	Sulfate adenylyltransferase, putative	ISS			PTHR43509:SF1	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05918	p38 MAPK pathway	P06021	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CANLF|Ensembl=ENSCAFG00000013828|UniProtKB=P11617	Adenosine receptor A2a	IDA			PTHR24246:SF27	ADENOSINE RECEPTOR A2A
P02750	Lipoate_biosynthesis	P03004	Lipoate synthase	DEIRA|EnsemblGenome=DR_0765|UniProtKB=Q9RWA4	Lipoyl synthase	ISS			PTHR10949:SF0	LIPOYL SYNTHASE, MITOCHONDRIAL
P02746	Heme biosynthesis	P02970	Coproporphyrinogen oxidase (oxygen independent)	PSEAE|EnsemblGenome=PA0386|UniProtKB=Q9I6A9	Probable oxidase	ISS			PTHR13932:SF5	OXYGEN-INDEPENDENT COPROPORPHYRINOGEN-III OXIDASE-LIKE PROTEIN YGGW
P04393	Ras Pathway	P04541	p90RSK	MACMU|Ensembl=ENSMMUG00000020532|UniProtKB=F7D8E6	Ribosomal protein S6 kinase	ISS	15632195	PubMed	PTHR24351:SF98	RIBOSOMAL PROTEIN S6 KINASE ALPHA-6
P02781	Threonine biosynthesis	P03189	Aspartate kinase	ARATH|TAIR=AT1G31230|UniProtKB=Q9SA18	Bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic	ISS			PTHR43070:SF3	HOMOSERINE DEHYDROGENASE
P02748	Isoleucine biosynthesis	P02994	Branched chain amino acid aminotransferase	ARATH|TAIR=AT3G49680|UniProtKB=Q9M401	Branched-chain-amino-acid aminotransferase 3, chloroplastic	ISS			PTHR42825:SF2	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 3, CHLOROPLASTIC
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	PANTR|Ensembl=ENSPTRG00000007461|UniProtKB=H2QA34	Furin (Paired basic amino acid cleaving enzyme)	ISS	10956649	PubMed	PTHR42884:SF1	FURIN
P00049	Parkinson disease	P01219	SAPK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	NAS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00046	Oxidative stress response	P01135	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	TAS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00638	PLCgamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P02738	De novo purine biosynthesis	P02907	dADP kinase	MOUSE|MGI=MGI=1861676|UniProtKB=O88425	Nucleoside diphosphate kinase 6	ISS			PTHR11349:SF70	NUCLEOSIDE DIPHOSPHATE KINASE 6
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00564	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	PANTR|Ensembl=ENSPTRG00000011042|UniProtKB=H2QGF5	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04397	p53 pathway by glucose deprivation	P04641	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IGI	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00590	IP3 R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00167	CD44 transmembrane fragment	MOUSE|MGI=MGI=88338|UniProtKB=P15379	CD44 antigen	IDA	12223485	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P00005	Angiogenesis	P00199	JNKK1	HUMAN|HGNC=6844|UniProtKB=P45985	Dual specificity mitogen-activated protein kinase kinase 4	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00022	General transcription by RNA polymerase I	P00649	TAF-IC	ARATH|TAIR=AT4G34340|UniProtKB=Q9SYZ9	Transcription initiation factor TFIID subunit 8	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	PANTR|Gene=TBPL2|UniProtKB=A6H907	TATA box-binding protein-like protein 2	ISS	600075	OMIM	PTHR10126:SF34	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 2
P00048	PI3 kinase pathway	P01199	Galpha	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IC	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04395	Vasopressin synthesis	P04597	Signal Peptide	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DROME|FlyBase=FBgn0000043|UniProtKB=P02572	Actin-42A	ISS	11889126	PubMed	PTHR11937:SF369	ACTIN-42A
P00036	Interleukin signaling pathway	P00996	STAT	PANTR|Ensembl=ENSPTRG00000009200|UniProtKB=H2QD20	Signal transducer and activator of transcription	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00009	Axon guidance mediated by netrin	P00364	cdc42	DANRE|ZFIN=ZDB-GENE-030131-8783|UniProtKB=Q52WY2	Ras-like protein Cdc42a	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00045	Notch signaling pathway	P01102	Sel 10	CANLF|Ensembl=ENSCAFG00000008141|UniProtKB=E2QUZ3	Uncharacterized protein	ISS			PTHR44007:SF6	F-BOX/WD REPEAT-CONTAINING PROTEIN 7
P06959	CCKR signaling map	P07153	RSK1/2	HUMAN|HGNC=10432|UniProtKB=P51812	Ribosomal protein S6 kinase alpha-3	RCA	9124559	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00057	Wnt signaling pathway	P01465	Ggamma	HUMAN|HGNC=4404|UniProtKB=P59768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IDA	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=101848|UniProtKB=P62881	Guanine nucleotide-binding protein subunit beta-5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	CHICK|Ensembl=ENSGALG00000028896|UniProtKB=R4GMK5	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF728	MYOSIN HEAVY CHAIN, SKELETAL MUSCLE, ADULT
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	MONDO|Ensembl=ENSMODG00000014746|UniProtKB=F6YN64	Uncharacterized protein (Fragment)	ISS	10331083	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00010	B cell activation	P00373	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IGI	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00005	Angiogenesis	P00193	SOS-1	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS			PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00036	Interleukin signaling pathway	P00968	Ikk	RAT|RGD=1306661|UniProtKB=G3V926	Conserved helix-loop-helix ubiquitous kinase (Predicted)	ISS	12235208	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DROME|FlyBase=FBgn0259680|UniProtKB=P83099	Putative protein kinase C delta type homolog	ISS	3755548	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	TAS	12810719	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00048	PI3 kinase pathway	P01190	PDK1 ACT	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	IDA	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05731	GABA-B receptor II signaling	P05754	Ggamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	SCHMA|EnsemblGenome=Smp_202970|UniProtKB=G4VLN1	Putative uncharacterized protein Smp_202970	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04393	Ras Pathway	P04542	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	TAS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P05913	Enkephalin release	P05974	G-Protein (i)	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	IC	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MONDO|Ensembl=ENSMODG00000011628|UniProtKB=F6U132	Actin-related protein 2/3 complex subunit 3	ISS	9359840	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	CANLF|Gene=DRD2|UniProtKB=Q9GJU1	D(2) dopamine receptor	ISS	2137198	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-2280|UniProtKB=Q6P025	Gnb3 protein	ISS	9754712	PubMed	PTHR19850:SF35	GNB3 PROTEIN
P00010	B cell activation	P00373	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IGI	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00029	Huntington disease	P00786	ARF	RAT|RGD=621275|UniProtKB=P61751	ADP-ribosylation factor 4	ISS	12932731	PubMed	PTHR11711:SF110	ADP-RIBOSYLATION FACTOR 4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MACMU|Ensembl=ENSMMUG00000017683|UniProtKB=F6UA63	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00644	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00012	Cadherin signaling pathway	P00476	Yes	MOUSE|MGI=MGI=99147|UniProtKB=Q04736	Tyrosine-protein kinase Yes	ISS	11078745	PubMed	PTHR24418:SF90	TYROSINE-PROTEIN KINASE YES
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MACMU|Ensembl=ENSMMUG00000009054|UniProtKB=F7F735	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00006	Apoptosis signaling pathway	P00274	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04559	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	IDA	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CANLF|Ensembl=ENSCAFG00000009967|UniProtKB=F1PGZ2	Muscarinic acetylcholine receptor	ISS	12181435	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00029	Huntington disease	P00811	Arp2/3 complex	CAEBR|Gene=CBG18174|UniProtKB=A8XT67	Protein CBR-ARX-3	ISS	12963527	gi	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P00005	Angiogenesis	P00203	Erk	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00036	Interleukin signaling pathway	P00965	ERK	MACMU|Ensembl=ENSMMUG00000008503|UniProtKB=F6TGJ6	Uncharacterized protein	ISS	8444355	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00047	PDGF signaling pathway	P01175	Shc	MOUSE|MGI=MGI=106180|UniProtKB=Q8BMC3	SHC-transforming protein 2	ISS	600560	OMIM	PTHR10337:SF5	SHC-TRANSFORMING PROTEIN 2
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00016	Cytoskeletal regulation by Rho GTPase	P00521	Profilin	ARATH|TAIR=AT4G29340|UniProtKB=Q38904	Profilin-3	ISS			PTHR11604:SF0	PROFILIN
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	98189216	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00034	Integrin signalling pathway	P00906	Rap1	XENTR|Xenbase=XB-GENE-5801166|UniProtKB=F6ZE26	Uncharacterized protein	ISS	10476970	PubMed	PTHR24070:SF382	RAS-RELATED PROTEIN RAP-1B
P00059	p53 pathway	G04696	Siah	HUMAN|HGNC=10857|UniProtKB=Q8IUQ4	E3 ubiquitin-protein ligase SIAH1	ISS	14985507	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00041	Metabotropic glutamate receptor group I pathway	P01058	Homer	XENTR|Xenbase=XB-GENE-5807410|UniProtKB=A9JTQ6	Homer1 protein	ISS	12653978	PubMed	PTHR10918:SF3	HOMER PROTEIN HOMOLOG 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-030131-7595|UniProtKB=Q6PBR4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00021	FGF signaling pathway	P00623	FGF	HUMAN|HGNC=3681|UniProtKB=P11487	Fibroblast growth factor 3	ISS			PTHR11486:SF26	FIBROBLAST GROWTH FACTOR 3
P05731	GABA-B receptor II signaling	P05760	AC	HUMAN|HGNC=235|UniProtKB=Q8NFM4	Adenylate cyclase type 4	ISS	9870949	PubMed	PTHR11920:SF286	ADENYLATE CYCLASE TYPE 4
P00021	FGF signaling pathway	P00637	MKK4,7	MACMU|Ensembl=ENSMMUG00000019842|UniProtKB=F7FU91	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00036	Interleukin signaling pathway	P00973	PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01084	CHT1	MOUSE|MGI=MGI=1927126|UniProtKB=Q8BGY9	High affinity choline transporter 1	RCA			PTHR11819:SF129	HIGH AFFINITY CHOLINE TRANSPORTER 1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00021	FGF signaling pathway	P00631	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	4504111	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00010	B cell activation	P00383	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00012	Cadherin signaling pathway	P00474	Wnt	PANTR|Ensembl=ENSPTRG00000004090|UniProtKB=H2Q4F7	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00012	Cadherin signaling pathway	P00470	F-actin	RAT|RGD=2026|UniProtKB=P68035	Actin, alpha cardiac muscle 1	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00021	FGF signaling pathway	P00632	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IGI	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00012	Cadherin signaling pathway	P00475	Frizzled	BOVIN|Ensembl=ENSBTAG00000010529|UniProtKB=F1MP23	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF75	FRIZZLED-6
P00034	Integrin signalling pathway	P00951	Jnk	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	ORNAN|Ensembl=ENSOANG00000010302|UniProtKB=F6TDQ6	Uncharacterized protein	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00004	Alzheimer disease-presenilin pathway	P00113	Erb-B4 transmembrane fragment	ORNAN|Ensembl=ENSOANG00000007021|UniProtKB=F7GAV2	Receptor protein-tyrosine kinase	ISS	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IDA	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P02763	Peptidoglycan biosynthesis	P03088	UDP-N-acetylmuramate dehydrogenase	DEIRA|EnsemblGenome=DR_0628|UniProtKB=Q9RWN8	UDP-N-acetylenolpyruvoylglucosamine reductase	ISS			PTHR21071:SF4	UDP-N-ACETYLENOLPYRUVOYLGLUCOSAMINE REDUCTASE
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	BOVIN|Ensembl=ENSBTAG00000008103|UniProtKB=P48644	Retinal dehydrogenase 1	IC			PTHR11699:SF140	RETINAL DEHYDROGENASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00057	Wnt signaling pathway	P01468	APC	PANTR|Ensembl=ENSPTRG00000017135|UniProtKB=H2QRB5	Adenomatous polyposis coli	ISS	8259518	PubMed	PTHR12607:SF11	ADENOMATOUS POLYPOSIS COLI PROTEIN
P00029	Huntington disease	P00785	Cytochrome c	DROME|FlyBase=FBgn0039651|UniProtKB=Q9VAM8	AT13706p	IDA	15163634	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	TAS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00059	p53 pathway	P01486	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00056	VEGF signaling pathway	P01414	PLC-gamma	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00021	FGF signaling pathway	P00624	14-3-3	RAT|RGD=3978|UniProtKB=P68511	14-3-3 protein eta	ISS	10407019	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IPI	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00924	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IPI	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	CAEBR|Gene=CBG06179|UniProtKB=A8X0Q9	Serine/threonine-protein phosphatase	ISS			PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00788	Calpain	PANTR|Ensembl=ENSPTRG00000010887|UniProtKB=H2QG59	Uncharacterized protein	ISS	11675509	PubMed	PTHR44408:SF3	CALPAIN SMALL SUBUNIT 1
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00046	Oxidative stress response	P01135	p38	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00892	Grb2	CAEEL|WormBase=WBGene00004774|UniProtKB=P29355	Sex muscle abnormal protein 5	ISS	4504111	gi	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01063	CAT	CAEBR|Gene=CBG08305|UniProtKB=A8X694	Protein CBR-CHA-1	ISS	97225904	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P00047	PDGF signaling pathway	P01157	MAPKAPK2	MOUSE|MGI=MGI=109298|UniProtKB=P49138	MAP kinase-activated protein kinase 2	ISS	14672329	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00038	JAK/STAT signaling pathway	P01027	STAT	MACMU|Ensembl=ENSMMUG00000010705|UniProtKB=F7G8V4	Signal transducer and activator of transcription	ISS	96210005	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00004	Alzheimer disease-presenilin pathway	P00153	gammacatenin	RAT|RGD=620412|UniProtKB=Q6P0K8	Junction plakoglobin	ISS	9172160	PubMed	PTHR23315:SF12	JUNCTION PLAKOGLOBIN
P00005	Angiogenesis	P00239	Eph	BOVIN|Ensembl=ENSBTAG00000015801|UniProtKB=A1L570	Ephrin-B1	ISS			PTHR11304:SF17	EPHRIN-B1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MACMU|Ensembl=ENSMMUG00000009483|UniProtKB=F6YUR1	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF142	MATRIX METALLOPROTEINASE-25
P02746	Heme biosynthesis	P02979	porphobilinogen synthase	MACMU|Ensembl=ENSMMUG00000031965|UniProtKB=F7GY51	Delta-aminolevulinic acid dehydratase	ISS			PTHR11458:SF0	DELTA-AMINOLEVULINIC ACID DEHYDRATASE
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	RAT|RGD=628837|UniProtKB=P60711	Actin, cytoplasmic 1	IC	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	PANTR|Gene=HTR2C|UniProtKB=Q5IS66	5-hydroxytryptamine receptor 2C	ISS			PTHR24247:SF32	5-HYDROXYTRYPTAMINE RECEPTOR 2C
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00034	Integrin signalling pathway	P00911	B-Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00899	IRS 1-4	BOVIN|Ensembl=ENSBTAG00000021308|UniProtKB=F1MYE0	Uncharacterized protein	ISS	15110093	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	MACMU|Ensembl=ENSMMUG00000012657|UniProtKB=F7E7J1	Uncharacterized protein	ISS	12787506	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00018	EGF receptor signaling pathway	P00542	EGFR	HUMAN|HGNC=3430|UniProtKB=P04626	Receptor tyrosine-protein kinase erbB-2	IGI	4758298	gi	PTHR24416:SF137	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2
P00029	Huntington disease	P00778	NMDA receptor	MOUSE|MGI=MGI=95823|UniProtKB=Q03391	Glutamate receptor ionotropic, NMDA 2D	IDA	11554549	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MONDO|Ensembl=ENSMODG00000023942|UniProtKB=F7F878	Uncharacterized protein	ISS	12181435	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	CANLF|Ensembl=ENSCAFG00000010476|UniProtKB=F1PS94	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P05918	p38 MAPK pathway	P06015	p38gamma	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	8920915	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00021	FGF signaling pathway	P00634	MEKK1-5	MACMU|Ensembl=ENSMMUG00000012387|UniProtKB=F7EB20	Uncharacterized protein	ISS	12168099	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	PANTR|Ensembl=ENSPTRG00000006510|UniProtKB=H2Q8K1	Presenilin	ISS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00036	Interleukin signaling pathway	P00976	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00035	Interferon-gamma signaling pathway	P00958	PIAS	MACMU|Ensembl=ENSMMUG00000004498|UniProtKB=F7GFM9	Protein inhibitor of activated STAT2	ISS	8682149	PubMed	PTHR10782:SF12	E3 SUMO-PROTEIN LIGASE PIAS2
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000005917|UniProtKB=F6QM53	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	IC	176892	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	XENTR|Xenbase=XB-GENE-941426|UniProtKB=Q28HZ4	Novel Rho protein	ISS	11360179	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00057	Wnt signaling pathway	P01435	SWI/SNF	CHICK|Ensembl=ENSGALG00000008431|UniProtKB=F1P3Q4	Uncharacterized protein	ISS	11532957	PubMed	PTHR10799:SF819	GLOBAL TRANSCRIPTION ACTIVATOR SNF2L1-RELATED
P00034	Integrin signalling pathway	P00920	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	ISS	8838325	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00006	Apoptosis signaling pathway	P00260	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00005	Angiogenesis	P00219	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04393	Ras Pathway	P04569	Cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00890	ELK	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	ISS	11050086	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	IDA	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00049	Parkinson disease	P01241	TH	MOUSE|MGI=MGI=98735|UniProtKB=P24529	Tyrosine 3-monooxygenase	TAS	12480184	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00057	Wnt signaling pathway	P01434	sFRP	MONDO|Ensembl=ENSMODG00000001183|UniProtKB=F7GHD3	Uncharacterized protein	ISS	9096311	PubMed	PTHR11309:SF45	SECRETED FRIZZLED-RELATED PROTEIN 2
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00005	Angiogenesis	P00223	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00021	FGF signaling pathway	P00629	PP2A	TAKRU|Ensembl=ENSTRUG00000011169|UniProtKB=H2TU36	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MONDO|Ensembl=ENSMODG00000005136|UniProtKB=F7EQH3	Uncharacterized protein (Fragment)	ISS	5031595	gi	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	ANOGA|EnsemblGenome=AGAP000162|UniProtKB=Q7QEV0	Cystathionine beta-synthase	ISS			PTHR10314:SF8	CYSTATHIONINE BETA-SYNTHASE-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g242065|UniProtKB=A7S0V7	Predicted protein	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00034	Integrin signalling pathway	P00923	Arf1	MONDO|Ensembl=ENSMODG00000013804|UniProtKB=F6SY88	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF294	ADP-RIBOSYLATION FACTOR 3
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P06664	Gonadotropin-releasing hormone receptor pathway	P06786	ERK1/2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	RCA	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00996	STAT	MONDO|Ensembl=ENSMODG00000014836|UniProtKB=F7D2D3	Signal transducer and activator of transcription	ISS	96102059	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	MOUSE|MGI=MGI=109284|UniProtKB=Q61144	Presenilin-2	TAS	12885769	PubMed	PTHR10202:SF13	PRESENILIN-2
P04393	Ras Pathway	P04548	ATF2	BOVIN|Ensembl=ENSBTAG00000002295|UniProtKB=F1N177	Uncharacterized protein	ISS	15218628	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01081	Ca2+ channel	HUMAN|HGNC=1399|UniProtKB=P54289	Voltage-dependent calcium channel subunit alpha-2/delta-1	ISS	21601730	PubMed	PTHR10166:SF6	VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-1
P00023	General transcription regulation	P00658	TBP-associated factors	PANTR|Ensembl=ENSPTRG00000013695|UniProtKB=H2REF4	Uncharacterized protein	ISS	10973244	PubMed	PTHR15138:SF18	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	IDA	12787066	PubMed	PTHR24055:SF330	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04393	Ras Pathway	P04558	p38	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	8920915	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	MOUSE|MGI=MGI=109284|UniProtKB=Q61144	Presenilin-2	IDA	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	RAT|RGD=2735|UniProtKB=Q63273	Glutamate receptor ionotropic, kainate 5	ISS	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	ORNAN|Ensembl=ENSOANG00000011383|UniProtKB=F6T6T3	Uncharacterized protein	ISS	10664585	PubMed	PTHR11462:SF7	TRANSCRIPTION FACTOR JUN-D
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00005	Angiogenesis	P00223	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000022513|UniProtKB=F6YNZ0	Uncharacterized protein	ISS	20012997	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IDA	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05916	Opioid prodynorphin pathway	P06002	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00048	PI3 kinase pathway	P01185	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT2G18170|UniProtKB=Q39027	Mitogen-activated protein kinase 7	ISS	12787066	PubMed	PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P00010	B cell activation	P00384	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IDA	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	YEAST|SGD=S000000028|UniProtKB=P31109	Synaptobrevin homolog 1	IC			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00047	PDGF signaling pathway	P01159	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MOUSE|MGI=MGI=1316745|UniProtKB=Q9Z0L4	Bone morphogenetic protein 15	TAS	9759503	PubMed	PTHR11848:SF22	BONE MORPHOGENETIC PROTEIN 15
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS			PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00029	Huntington disease	P00811	Arp2/3 complex	RAT|RGD=1311791|UniProtKB=Q4KLF8	Actin-related protein 2/3 complex subunit 5	ISS	9230079	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00018	EGF receptor signaling pathway	P00539	14-3-3	TAKRU|Ensembl=ENSTRUG00000004697|UniProtKB=H2SFG7	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00019	Endothelin signaling pathway	P00589	Akt	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	IGI	12089061	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	IC	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00023	General transcription regulation	P00669	TFIIEalpha	RAT|RGD=1306851|UniProtKB=G3V992	General transcription factor II E, polypeptide 1 (Alpha subunit)	ISS	92065982	PubMed	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00025	Hedgehog signaling pathway	P00682	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05916	Opioid prodynorphin pathway	P05999	provasopressin	DANRE|ZFIN=ZDB-GENE-030407-2|UniProtKB=F8W5D0	Uncharacterized protein (Fragment)	ISS			PTHR11681:SF13	SUBFAMILY NOT NAMED
P05731	GABA-B receptor II signaling	P05752	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00007	Axon guidance mediated by semaphorins	P00331	PAK	HUMAN|HGNC=8590|UniProtKB=Q13153	Serine/threonine-protein kinase PAK 1	ISS	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00012	Cadherin signaling pathway	P00464	Fyn	RAT|RGD=2641|UniProtKB=Q62844	Tyrosine-protein kinase Fyn	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_188187|UniProtKB=E9GJ31	Guanine nucleotide binding protein, q polypeptide	ISS	1333286	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	XENTR|Xenbase=XB-GENE-484003|UniProtKB=Q6P365	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P05913	Enkephalin release	P05974	G-Protein (i)	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000018684|UniProtKB=C7G3M7	Glutamate receptor, metabotropic 1	ISS			PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P02731	Biotin biosynthesis	P02858	8-Amino-7-oxononanoate synthase	DEIRA|EnsemblGenome=DR_2346|UniProtKB=Q9RRY6	Aminotransferase, class II	ISS			PTHR13693:SF77	8-AMINO-7-OXONONANOATE SYNTHASE
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=98954|UniProtKB=P21552	Protein Wnt-2	IDA	11266476	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00233	CSL	RAT|RGD=1310557|UniProtKB=F1LNW1	Protein Rbpj	ISS	8406481	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	ARATH|TAIR=AT5G61210|UniProtKB=Q9S7P9	SNAP25 homologous protein SNAP33	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=105372|UniProtKB=P49660	Somatostatin receptor type 4	IDA	12441358	PubMed	PTHR24229:SF52	SOMATOSTATIN RECEPTOR TYPE 4
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	MACMU|Ensembl=ENSMMUG00000018375|UniProtKB=F7H1D5	Neurogenic locus notch homolog protein 2 isoform 1 preproprotein	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	XENTR|Xenbase=XB-GENE-957248|UniProtKB=Q6GLE6	Serine/threonine-protein phosphatase	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MONDO|Ensembl=ENSMODG00000001430|UniProtKB=F7BCI5	Uncharacterized protein	ISS	12890691	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00780	Microtubule	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g167737|UniProtKB=A7S8I3	Predicted protein	ISS			PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00005	Angiogenesis	P00236	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01307	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	RAT|RGD=3188|UniProtKB=Q9QW30	Neurogenic locus notch homolog protein 2	IDA	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	ORNAN|Ensembl=ENSOANG00000000818|UniProtKB=F6PLI7	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00021	FGF signaling pathway	P00624	14-3-3	ORNAN|Ensembl=ENSOANG00000007305|UniProtKB=F6XW91	Uncharacterized protein	ISS	12861023	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	IC	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	176910	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01161	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	3449797	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	MACMU|Ensembl=ENSMMUG00000021075|UniProtKB=F7GY91	Uncharacterized protein	ISS	11756405	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MOUSE|MGI=MGI=1343142|UniProtKB=Q9WV32	Actin-related protein 2/3 complex subunit 1B	ISS	12932731	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00034	Integrin signalling pathway	P00942	Fyn	BOVIN|Ensembl=ENSBTAG00000011851|UniProtKB=A0JNB0	Tyrosine-protein kinase Fyn	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	CHICK|Ensembl=ENSGALG00000006885|UniProtKB=P08642	GTPase HRas	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	MOUSE|MGI=MGI=94924|UniProtKB=P61168	D(2) dopamine receptor	RCA	1319557	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00056	VEGF signaling pathway	P01408	Akt/PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01192	p110	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06768	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	RCA	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	DICDI|dictyBase=DDB_G0269102|UniProtKB=O96625	Actin-related protein 2/3 complex subunit 4	ISS	5031595	gi	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	RAT|RGD=3272|UniProtKB=P28840	Neuroendocrine convertase 1	IDA			PTHR42884:SF14	NEUROENDOCRINE CONVERTASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05916	Opioid prodynorphin pathway	P06002	G-protein	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IDA	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MONDO|Ensembl=ENSMODG00000009514|UniProtKB=F7EVK3	Uncharacterized protein	ISS	10207617	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	MYCTU|EnsemblGenome=Rv2220|UniProtKB=P9WN39	Glutamine synthetase 1	ISS			PTHR43407:SF1	LENGSIN
P00047	PDGF signaling pathway	P01160	IP3 receptor	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00018	EGF receptor signaling pathway	P00539	14-3-3	ORYSJ|EnsemblGenome=OS11G0546900|UniProtKB=Q2R2W2	14-3-3-like protein GF14-D	ISS	20493542	PubMed	PTHR18860:SF34	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01182	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8669|UniProtKB=Q9Y5H8	Protocadherin alpha-3	IDA	8120095	PubMed	PTHR24028:SF93	PROTOCADHERIN ALPHA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	MACMU|Ensembl=ENSMMUG00000010173|UniProtKB=F7AGU8	Presenilin	ISS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=1921305|UniProtKB=Q8K4S1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	10934033	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	BOVIN|Ensembl=ENSBTAG00000018989|UniProtKB=A5D7D8	GRM3 protein	ISS	9407094	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04568	MKK3/6	RAT|RGD=1306620|UniProtKB=B1H230	Map2k3 protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00006	Apoptosis signaling pathway	P00297	NFkappaB	MACMU|Ensembl=ENSMMUG00000007418|UniProtKB=F6QZH6	Uncharacterized protein	ISS	10049353	PubMed	PTHR24169:SF1	TRANSCRIPTION FACTOR P65
P00048	PI3 kinase pathway	P01189	PTEN	TAKRU|Ensembl=ENSTRUG00000009851|UniProtKB=H2TJ90	Uncharacterized protein	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	YEAST|SGD=S000006189|UniProtKB=P32383	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00059	p53 pathway	P01486	Akt	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	TAS	12086862	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01218	alpha-Synuclein	RAT|RGD=3729|UniProtKB=P37377	Alpha-synuclein	TAS	9278044	PubMed	PTHR13820:SF5	ALPHA-SYNUCLEIN
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00029	Huntington disease	P00790	beta-Tubulin	PANTR|Ensembl=ENSPTRG00000017675|UniProtKB=H2QS81	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	PANTR|Ensembl=ENSPTRG00000012547|UniProtKB=H2QIU3	Uncharacterized protein	ISS	2433589	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	IC	14744463	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00052	TGF-beta signaling pathway	P01275	P38	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	TAS	8925912	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00049	Parkinson disease	P01212	p38 MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P04393	Ras Pathway	P04558	p38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CAEBR|Gene=CBG18256|UniProtKB=A8XS95	Protein CBR-ACT-5	ISS	10974003	PubMed	PTHR11937:SF352	ACTIN
P00018	EGF receptor signaling pathway	P00547	PP2A	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	MONDO|Ensembl=ENSMODG00000018237|UniProtKB=F6PG65	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	HUMAN|HGNC=705|UniProtKB=O15144	Actin-related protein 2/3 complex subunit 2	ISS	17943202	gi	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P04393	Ras Pathway	P04559	Rac	DROME|FlyBase=FBgn0014011|UniProtKB=P48554	Ras-related protein Rac2	IDA	12932731	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00059	p53 pathway	P04614	Cyclin B	PANTR|Ensembl=ENSPTRG00000016942|UniProtKB=H2QR05	Cyclin B1	ISS	1019642	gi	PTHR10177:SF193	G2/MITOTIC-SPECIFIC CYCLIN-B1
P00037	Ionotropic glutamate receptor pathway	P01026	KA	RAT|RGD=2735|UniProtKB=Q63273	Glutamate receptor ionotropic, kainate 5	ISS	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	TAS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05918	p38 MAPK pathway	P06043	ASK1	BOVIN|Ensembl=ENSBTAG00000009065|UniProtKB=F1MXH6	Uncharacterized protein	ISS	12968034	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00019	Endothelin signaling pathway	P00574	Big ET1-4	RAT|RGD=2534|UniProtKB=P13207	Endothelin-3	IGI	88320556	PubMed	PTHR13874:SF11	ENDOTHELIN-3
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=1768|UniProtKB=Q9ULB4	Cadherin-9	IDA	8120095	PubMed	PTHR24027:SF99	CADHERIN-9
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	91072385	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00049	Parkinson disease	P01236	Casein kinase II	NEUCR|EnsemblGenome=EFNCRG00000002934|UniProtKB=Q8TG13	Casein kinase II subunit alpha	IDA	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00269	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	YEAST|SGD=S000000095|UniProtKB=P39567	Putative inosine-5'-monophosphate dehydrogenase 1	ISS			PTHR11911:SF111	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE
P02746	Heme biosynthesis	P02979	porphobilinogen synthase	YEAST|SGD=S000003008|UniProtKB=P05373	Delta-aminolevulinic acid dehydratase	ISS			PTHR11458:SF0	DELTA-AMINOLEVULINIC ACID DEHYDRATASE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DANRE|ZFIN=ZDB-GENE-030131-6503|UniProtKB=Q7ZUC5	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF297	PROTEIN KINASE C DELTA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Ensembl=ENSPTRG00000022245|UniProtKB=H2QZ29	Uncharacterized protein	ISS	20112749	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00054	Toll receptor signaling pathway	P01351	TLR2,4,7	MACMU|Ensembl=ENSMMUG00000014254|UniProtKB=B3Y653	Toll-like receptor 7	ISS			PTHR44312:SF1	TOLL-LIKE RECEPTOR 7
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00046	Oxidative stress response	P01138	MKK4	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS	9305639	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000005917|UniProtKB=F6QM53	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00053	T cell activation	P01332	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00828	Galphai	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	RCA			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00054	Toll receptor signaling pathway	P01352	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	TAS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	CHICK|Ensembl=ENSGALG00000009320|UniProtKB=Q4JIM4	Presenilin-1	IDA	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	MOUSE|MGI=MGI=97513|UniProtKB=P23188	Furin	IDA	10956649	PubMed	PTHR42884:SF1	FURIN
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00775	Rac	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS			PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	RCA			PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00047	PDGF signaling pathway	P01154	Ras	CHICK|Ensembl=ENSGALG00000006885|UniProtKB=P08642	GTPase HRas	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CHICK|Ensembl=ENSGALG00000028896|UniProtKB=R4GMK5	Uncharacterized protein	IC	89264452	PubMed	PTHR13140:SF728	MYOSIN HEAVY CHAIN, SKELETAL MUSCLE, ADULT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05734	Synaptic vesicle trafficking	P05779	Synaptobrevin	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	RCA	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00052	TGF-beta signaling pathway	P01275	P38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02763	Peptidoglycan biosynthesis	P03091	D-alanine-D-alanine ligase	BACTN|EnsemblGenome=BT_3713|UniProtKB=Q8A1F3	D-alanine--D-alanine ligase	ISS			PTHR23132:SF12	D-ALANINE--D-ALANINE LIGASE B
P00036	Interleukin signaling pathway	P00980	IRS1/2	BOVIN|Ensembl=ENSBTAG00000021308|UniProtKB=F1MYE0	Uncharacterized protein	ISS	1311924	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-478663|UniProtKB=F7EG64	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05915	Opioid proenkephalin pathway	P05987	peptide F	PANTR|Ensembl=ENSPTRG00000020270|UniProtKB=H2QW70	Proenkephalin	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00009	Axon guidance mediated by netrin	P00361	Ena	MOUSE|MGI=MGI=108360|UniProtKB=Q03173	Protein enabled homolog	ISS			PTHR11202:SF1	PROTEIN ENABLED HOMOLOG
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	HUMAN|HGNC=406|UniProtKB=P30038	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	IC			PTHR14516:SF3	DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE, MITOCHONDRIAL
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	IC	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	MOUSE|MGI=MGI=1859169|UniProtKB=O35484	Antizyme inhibitor 1	ISS			PTHR11482:SF7	ANTIZYME INHIBITOR 1
P00036	Interleukin signaling pathway	P00983	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00557	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	IGI	96320556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00079	alpha7 nicotinic acetylcholine receptor	HUMAN|HGNC=1960|UniProtKB=P36544	Neuronal acetylcholine receptor subunit alpha-7	IDA	85270494	PubMed	PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P00036	Interleukin signaling pathway	P00965	ERK	HUMAN|HGNC=24667|UniProtKB=Q8TD08	Mitogen-activated protein kinase 15	IC	11875070	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04398	p53 pathway feedback loops 2	P04657	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00912	Arp2/3	PANTR|Ensembl=ENSPTRG00000019449|UniProtKB=H2QV01	Actin related protein 2/3 complex, subunit 1B, 41kDa	ISS	12932731	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00019	Endothelin signaling pathway	P00571	Pro ET1-4	MOUSE|MGI=MGI=95283|UniProtKB=P22387	Endothelin-1	ISS	12893655	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00870	IL2	MOUSE|MGI=MGI=96557|UniProtKB=P04401	Interleukin-5	IDA			PTHR45421:SF1	INTERLEUKIN-5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	PANTR|Ensembl=ENSPTRG00000002161|UniProtKB=H2Q8J8	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF26	REGULATOR OF G-PROTEIN SIGNALING 7
P00052	TGF-beta signaling pathway	P01275	P38	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	TAS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	PANTR|Ensembl=ENSPTRG00000013825|UniProtKB=H2RAK4	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	CAEEL|WormBase=WBGene00004273|UniProtKB=Q94148	RAB family	ISS			PTHR24073:SF316	IP08727P-RELATED
P02785	Valine biosynthesis	P03216	Acetolactate synthase	MYCTU|EnsemblGenome=Rv3003c|UniProtKB=P9WG41	Acetolactate synthase large subunit IlvB1	ISS			PTHR18968:SF116	ACETOLACTATE SYNTHASE ISOZYME 3 LARGE SUBUNIT
P00019	Endothelin signaling pathway	P00589	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00060	Ubiquitin proteasome pathway	P01490	E3	PANTR|Ensembl=ENSPTRG00000020395|UniProtKB=H2QWD9	E3 ubiquitin-protein ligase	ISS			PTHR11254:SF299	NEDD4-LIKE E3 UBIQUITIN-PROTEIN LIGASE WWP1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=11334|UniProtKB=P35346	Somatostatin receptor type 5	IDA	12441358	PubMed	PTHR24229:SF20	SOMATOSTATIN RECEPTOR TYPE 5
P00059	p53 pathway	P04619	HMG1	PANTR|Ensembl=ENSPTRG00000014690|UniProtKB=H2QM67	Uncharacterized protein	ISS			PTHR13711:SF164	HIGH MOBILITY GROUP PROTEIN B1-RELATED
P04393	Ras Pathway	P04573	Elk-1	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	10487205	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IDA	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00052	TGF-beta signaling pathway	P01292	RSmads	CHICK|Ensembl=ENSGALG00000007870|UniProtKB=P84023	Mothers against decapentaplegic homolog 3	ISS	9395284	PubMed	PTHR13703:SF25	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3
P00054	Toll receptor signaling pathway	P01351	TLR2,4,7	PANTR|Ensembl=ENSPTRG00000021299|UniProtKB=H2QXS5	Toll-like receptor 4	ISS			PTHR44568:SF1	TOLL-LIKE RECEPTOR 4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00049	Parkinson disease	P01227	20S proteasome	TAKRU|Ensembl=ENSTRUG00000016631|UniProtKB=H2V006	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF13	PROTEASOME SUBUNIT ALPHA TYPE-4
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00029	Huntington disease	P00796	Kainate receptor	CANLF|Ensembl=ENSCAFG00000004930|UniProtKB=E2RFB5	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	3755548	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DICPU|Gene=DICPUDRAFT_93216|UniProtKB=F1A421	Guanine nucleotide-binding protein subunit beta	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	DROME|FlyBase=FBgn0033571|UniProtKB=Q7JZF5	RE34924p	ISS	11313498	gi	PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P00021	FGF signaling pathway	P00632	Akt	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	IGI	12655147	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00057	Wnt signaling pathway	P01464	Pygo	MACMU|Ensembl=ENSMMUG00000006579|UniProtKB=F7HPS9	Uncharacterized protein	ISS	11955446	PubMed	PTHR23194:SF7	PYGOPUS HOMOLOG 2
P00021	FGF signaling pathway	P00642	MEK1-2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00049	Parkinson disease	P01212	p38 MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00029	Huntington disease	P00799	JNK-2	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	HUMAN|HGNC=9508|UniProtKB=P49768	Presenilin-1	IDA	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00005	Angiogenesis	P00181	SHP2	CANLF|Ensembl=ENSCAFG00000008894|UniProtKB=F1Q3J6	Tyrosine-protein phosphatase non-receptor type	ISS	14534538	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00029	Huntington disease	P00786	ARF	ARATH|TAIR=AT3G03120|UniProtKB=Q9M9N1	ADP-ribosylation factor B1C	IPI	12932731	PubMed	PTHR11711:SF300	ADP-RIBOSYLATION FACTOR B1C
P00010	B cell activation	P00382	Syk	HUMAN|HGNC=11491|UniProtKB=P43405	Tyrosine-protein kinase SYK	IGI	8137818	PubMed	PTHR24418:SF231	TYROSINE-PROTEIN KINASE SYK
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IDA	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	ORYSJ|EnsemblGenome=OS10G0521700|UniProtKB=Q8LNI5	Os10g0521700 protein	TAS			PTHR24057:SF19	SHAGGY-RELATED PROTEIN KINASE BETA-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MACMU|Ensembl=ENSMMUG00000002134|UniProtKB=F6UNV6	Ribosomal protein S6 kinase	ISS	10558991	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00010	B cell activation	P00392	I kappa B	RAT|RGD=3171|UniProtKB=Q63746	NF-kappa-B inhibitor alpha	ISS	14665694	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95818|UniProtKB=Q61626	Glutamate receptor ionotropic, kainate 5	ISS	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00010	B cell activation	P00392	I kappa B	PANTR|Ensembl=ENSPTRG00000006265|UniProtKB=H2Q867	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	ISS	10811867	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DANRE|ZFIN=ZDB-GENE-030131-55|UniProtKB=Q6XNL8	Actin	ISS	11889139	PubMed	PTHR11937:SF263	ACTIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TRIAD|EnsemblGenome=TriadG49626|UniProtKB=B3RKR4	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00034	Integrin signalling pathway	P00912	Arp2/3	BOVIN|Ensembl=ENSBTAG00000046248|UniProtKB=Q58CQ2	Actin-related protein 2/3 complex subunit 1B	IPI	12963527	gi	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IDA	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	DICDI|dictyBase=DDB_G0279407|UniProtKB=P02599	Calmodulin	ISS	9753452	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00035	Interferon-gamma signaling pathway	P00953	Jak1	MACMU|Ensembl=ENSMMUG00000018566|UniProtKB=F6YLX1	Tyrosine-protein kinase	ISS	9637709	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05730	Endogenous cannabinoid signaling	P05746	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00049	Parkinson disease	P01230	Src kinase	MONDO|Ensembl=ENSMODG00000009310|UniProtKB=F7GJZ7	Tyrosine-protein kinase	ISS	7687537	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P02736	Coenzyme A biosynthesis	P02883	Pantothenoylcysteine decarboxylase	THEMA|EnsemblGenome=TM_1687|UniProtKB=Q9X213	DNA/pantothenate metabolism flavoprotein	ISS			PTHR14359:SF6	PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE
P00052	TGF-beta signaling pathway	P01290	TAB	MACMU|Ensembl=ENSMMUG00000012103|UniProtKB=F7H8X1	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform alpha	ISS	8638164	PubMed	PTHR13832:SF533	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MOUSE|MGI=MGI=1276116|UniProtKB=B2RWS6	Histone acetyltransferase p300	ISS	10664585	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00005	Angiogenesis	P00215	Nck	HUMAN|HGNC=7665|UniProtKB=O43639	Cytoplasmic protein NCK2	ISS	12874226	PubMed	PTHR44108:SF1	CYTOPLASMIC PROTEIN NCK2
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	BACTN|EnsemblGenome=BT_0785|UniProtKB=Q8A9N0	Glutamine synthetase I	ISS			PTHR43407:SF1	LENGSIN
P05731	GABA-B receptor II signaling	P05760	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IDA	12810719	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00546	GAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	227170	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00029	Huntington disease	P00786	ARF	ARATH|TAIR=AT5G14670|UniProtKB=Q9LYJ3	ADP-ribosylation factor A1B	IPI	12932731	PubMed	PTHR11711:SF210	ADP-RIBOSYLATION FACTOR 2-A-RELATED
P00004	Alzheimer disease-presenilin pathway	P00168	E-cadherin intracellular fragment	MACMU|Ensembl=ENSMMUG00000010393|UniProtKB=F7D992	Uncharacterized protein	ISS	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	TAKRU|Ensembl=ENSTRUG00000015959|UniProtKB=H2UV27	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00381	Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	IGI	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00019	Endothelin signaling pathway	P00591	PLCbeta	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00037	Ionotropic glutamate receptor pathway	P01018	Glu1	BOVIN|Ensembl=ENSBTAG00000005800|UniProtKB=F1N3G8	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	SCHPO|PomBase=SPBC32H8.07|UniProtKB=Q10282	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00005	Angiogenesis	P00251	cPLA2	MOUSE|MGI=MGI=1196403|UniProtKB=Q08EC7	Pla2g4c protein	ISS			PTHR10728:SF39	CYTOSOLIC PHOSPHOLIPASE A2 GAMMA
P00017	DNA replication	P00536	DNA Topisomerase	BOVIN|Ensembl=ENSBTAG00000019262|UniProtKB=F1MDU7	DNA topoisomerase 2	ISS			PTHR10169:SF46	DNA TOPOISOMERASE 2-ALPHA
P00036	Interleukin signaling pathway	P00975	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	20908895	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00006	Apoptosis signaling pathway	P00314	MKK3	BOVIN|Ensembl=ENSBTAG00000010576|UniProtKB=A4IFH7	MAP2K3 protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P00036	Interleukin signaling pathway	P00983	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00249	PAK	CHICK|Ensembl=ENSGALG00000000681|UniProtKB=E1C3P6	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P05730	Endogenous cannabinoid signaling	P05748	mGluR	MACMU|Ensembl=ENSMMUG00000010184|UniProtKB=F6SR09	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00012	Cadherin signaling pathway	P00470	F-actin	CRYNJ|EnsemblGenome=CNA04650|UniProtKB=Q5KP06	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00053	T cell activation	P01305	Calmodulin	MACMU|Ensembl=ENSMMUG00000017921|UniProtKB=F7EDG8	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF335	CALMODULIN, STRIATED MUSCLE
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	PANTR|Ensembl=ENSPTRG00000001749|UniProtKB=H2Q0Q4	Uncharacterized protein	ISS	14507926	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_188187|UniProtKB=E9GJ31	Guanine nucleotide binding protein, q polypeptide	ISS	9166716	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	IDA	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01446	Calcineurin	DROME|FlyBase=FBgn0267912|UniProtKB=Q9VXF1	Serine/threonine-protein phosphatase 2B catalytic subunit 3	IDA	12015605	PubMed	PTHR11668:SF118	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	ISS	14765990	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00048	PI3 kinase pathway	P01179	PKB	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00050	Plasminogen activating cascade	P01258	Fibrin C-terminal truncation	CHICK|Gene=FGA|UniProtKB=P14448	Fibrinogen alpha chain	ISS	1706798	gi	PTHR19143:SF232	FIBRINOGEN ALPHA CHAIN
P00057	Wnt signaling pathway	P01446	Calcineurin	PANTR|Ensembl=ENSPTRG00000002631|UniProtKB=H2Q237	Serine/threonine-protein phosphatase	ISS	12091710	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	PANTR|Ensembl=ENSPTRG00000005122|UniProtKB=H2Q6A6	Uncharacterized protein	ISS	11907044	PubMed	PTHR44025:SF2	PROLOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00397	IKK	HUMAN|HGNC=1974|UniProtKB=O15111	Inhibitor of nuclear factor kappa-B kinase subunit alpha	IGI	14499113	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00029	Huntington disease	P00807	Actin	DANRE|ZFIN=ZDB-GENE-000329-3|UniProtKB=Q7ZVF9	Actin, cytoplasmic 2	ISS	3487386	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00756	Recoverin	RAT|RGD=620258|UniProtKB=G3V6G4	Protein Rcvrn	IDA	9753452	PubMed	PTHR23055:SF20	RECOVERIN
P00021	FGF signaling pathway	P00642	MEK1-2	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IGI	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PANTR|Ensembl=ENSPTRG00000009762|UniProtKB=H2QE24	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347742|UniProtKB=E9FZ00	Cytoplasmatic actin	ISS	11889126	PubMed	PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00049	Parkinson disease	P01242	Casein kinase I	HUMAN|HGNC=2455|UniProtKB=P78368	Casein kinase I isoform gamma-2	IDA	11437445	PubMed	PTHR11909:SF157	CASEIN KINASE I ISOFORM GAMMA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01230	Src kinase	MONDO|Ensembl=ENSMODG00000017905|UniProtKB=F7FG65	Tyrosine-protein kinase	ISS	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Ensembl=ENSGALG00000028749|UniProtKB=Q5ZMQ2	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00005	Angiogenesis	P00254	GTPase	EMENI|EnsemblGenome=CADANIAG00003322|UniProtKB=Q9C3Y4	GTP-binding protein rhoA	ISS			PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IC	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	RAT|RGD=2846|UniProtKB=P28564	5-hydroxytryptamine receptor 1B	IDA			PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	IC	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00965	ERK	BOVIN|Ensembl=ENSBTAG00000005865|UniProtKB=G5E577	Uncharacterized protein	ISS	8444355	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MACMU|Ensembl=ENSMMUG00000006492|UniProtKB=F7H998	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00010	B cell activation	P00373	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MOUSE|MGI=MGI=2448715|UniProtKB=Q810W6	C-X-C chemokine receptor type 1	ISS	4504683	gi	PTHR10489:SF916	C-X-C CHEMOKINE RECEPTOR TYPE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANAL|CGD=CAL0003231|UniProtKB=Q5ANK2	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00005	Angiogenesis	P00223	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IPI	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00951	Jnk	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00034	Integrin signalling pathway	P00909	ASAP1	RAT|RGD=708452|UniProtKB=Q62848	ADP-ribosylation factor GTPase-activating protein 1	IPI			PTHR23180:SF35	ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	HUMAN|HGNC=6093|UniProtKB=P14616	Insulin receptor-related protein	ISS	10226785	PubMed	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00053	T cell activation	P01312	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00005	Angiogenesis	P00183	Shc	MOUSE|MGI=MGI=98296|UniProtKB=P98083	SHC-transforming protein 1	ISS	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	IC	15737619	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g245041|UniProtKB=A7SG27	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00036	Interleukin signaling pathway	P00996	STAT	BOVIN|Gene=STAT5A|UniProtKB=Q95115	Signal transducer and activator of transcription 5A	IC	14662325	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00055	Transcription regulation by bZIP transcription factor	P01395	TFIIE	MACMU|Ensembl=ENSMMUG00000001596|UniProtKB=F7GV34	General transcription factor IIE subunit 1	ISS	92065982	PubMed	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00012	Cadherin signaling pathway	P00462	Casein kinase II	BOVIN|Gene=CSNK2A2|UniProtKB=P20427	Casein kinase II subunit alpha'	ISS	10617630	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P04393	Ras Pathway	P04552	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	ORNAN|Ensembl=ENSOANG00000010302|UniProtKB=F6TDQ6	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00036	Interleukin signaling pathway	P00986	eNOS	MOUSE|MGI=MGI=97362|UniProtKB=P70313	Nitric oxide synthase, endothelial	ISS	10435050	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00006	Apoptosis signaling pathway	P00310	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	11832947	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00048	PI3 kinase pathway	P01189	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	88241036	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00029	Huntington disease	P00807	Actin	DANRE|ZFIN=ZDB-GENE-050417-267|UniProtKB=F1QUN8	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF263	ACTIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	CANLF|Ensembl=ENSCAFG00000004956|UniProtKB=E2REH3	Uncharacterized protein	ISS	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P02785	Valine biosynthesis	P03218	Dihydroxy isovalerate dehydratase	YEAST|SGD=S000003777|UniProtKB=P39522	Dihydroxy-acid dehydratase, mitochondrial	ISS			PTHR21000:SF5	DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04572	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00056	VEGF signaling pathway	P01413	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00030	Hypoxia response via HIF activation	P00819	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00020	FAS signaling pathway	P00600	PARP	HUMAN|HGNC=273|UniProtKB=Q9Y6F1	Poly [ADP-ribose] polymerase 3	TAS	12101391	PubMed	PTHR10459:SF66	POLY  ADP-RIBOSE  POLYMERASE 3
P00019	Endothelin signaling pathway	P00589	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00059	p53 pathway	P04609	PI3K	ARATH|TAIR=AT1G60490|UniProtKB=P42339	Phosphatidylinositol 3-kinase VPS34	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00034	Integrin signalling pathway	P00947	Laminin	MOUSE|MGI=MGI=105382|UniProtKB=Q61001	Laminin subunit alpha-5	IPI	2538453	PubMed	PTHR10574:SF261	LAMININ SUBUNIT ALPHA-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PHYIT|EnsemblGenome=PITG_15078|UniProtKB=D0NRL5	Actin-like protein	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	12885769	PubMed	PTHR10202:SF13	PRESENILIN-2
P05731	GABA-B receptor II signaling	P05754	Ggamma	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00003	Alzheimer disease-amyloid secretase pathway	P00107	kinesin	CAEBR|Gene=CBG09366|UniProtKB=A8X994	Protein CBR-KLC-2	ISS	11740561	PubMed	PTHR19959:SF207	KINESIN LIGHT CHAIN
P00057	Wnt signaling pathway	P01465	Ggamma	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	IDA	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	IDA	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00054	Toll receptor signaling pathway	P01369	MKK1	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00030	Hypoxia response via HIF activation	P00819	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00127	APP	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00057	Wnt signaling pathway	P01448	CBP	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00010	B cell activation	P00374	Lyn	CANLF|Ensembl=ENSCAFG00000007034|UniProtKB=E2RBB8	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00006	Apoptosis signaling pathway	P00269	MAPK	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01286	TGFbeta	PANTR|Ensembl=ENSPTRG00000000572|UniProtKB=H2PYQ7	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF119	BONE MORPHOGENETIC PROTEIN 8A
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MOUSE|MGI=MGI=102522|UniProtKB=Q8R3Z5	Voltage-dependent L-type calcium channel subunit beta-1	IC	10514528	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00021	FGF signaling pathway	P00629	PP2A	YEAST|SGD=S000003158|UniProtKB=Q00362	Protein phosphatase PP2A regulatory subunit B	ISS			PTHR11871:SF0	PROTEIN PHOSPHATASE PP2A 55 KDA REGULATORY SUBUNIT
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00053	T cell activation	P01309	fos	MONDO|Ensembl=ENSMODG00000005927|UniProtKB=F6WX28	Uncharacterized protein	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05915	Opioid proenkephalin pathway	P05994	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=1306541|UniProtKB=D3ZVF3	Phosphoinositide-3-kinase, class 2, beta polypeptide (Predicted)	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05912	Dopamine receptor mediated signaling pathway	P05959	FLNA	HUMAN|HGNC=3754|UniProtKB=P21333	Filamin-A	IPI	11911837	PubMed	PTHR43998:SF6	FILAMIN-A
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00226	Delta/Serrate	DANRE|ZFIN=ZDB-GENE-011128-3|UniProtKB=Q5TZK8	Delta-like protein	ISS	9806913	PubMed	PTHR44097:SF1	PROTEIN JAGGED-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000022513|UniProtKB=F6YNZ0	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P02750	Lipoate_biosynthesis	P03003	Lipoyl-protein ligase	RAT|RGD=1305211|UniProtKB=D3Z9Z2	Putative lipoyltransferase 2, mitochondrial	ISS			PTHR10993:SF7	LIPOYLTRANSFERASE 2, MITOCHONDRIAL-RELATED
P00005	Angiogenesis	P00223	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IGI	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	DROME|FlyBase=FBgn0026439|UniProtKB=O77062	Excitatory amino acid transporter 1, isoform A	ISS	96032356	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	HUMAN|HGNC=1402|UniProtKB=Q08289	Voltage-dependent L-type calcium channel subunit beta-2	ISS	20088160	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00018	EGF receptor signaling pathway	P00564	Rac	DICDI|dictyBase=DDB_G0279605|UniProtKB=P34148	Rho-related protein racB	IGI	11973360	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000002339|UniProtKB=H2R368	Uncharacterized protein	ISS	20088160	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P02751	Lysine biosynthesis	P03009	Aspartokinase	GLOVI|Gene=BAC89715|UniProtKB=Q7NJQ8	Aspartate kinase	ISS			PTHR21499:SF3	ASPARTOKINASE
P00059	p53 pathway	P01486	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01336	Jnk	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IGI	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	IDA	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05913	Enkephalin release	P05977	G-Protein (s)	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00047	PDGF signaling pathway	P01147	Nck	CANLF|Ensembl=ENSCAFG00000007451|UniProtKB=E2RHV6	Uncharacterized protein	ISS	11689432	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P00029	Huntington disease	P00776	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P05726	2-arachidonoylglycerol biosynthesis	P05736	DGL	PANTR|Ensembl=ENSPTRG00000020038|UniProtKB=H2QVT7	Lipoprotein lipase	ISS			PTHR11610:SF3	LIPOPROTEIN LIPASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00056	VEGF signaling pathway	P01422	eNOS	BOVIN|Gene=NOS3|UniProtKB=P29473	Nitric oxide synthase, endothelial	ISS	93055452	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00049	Parkinson disease	P01211	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00947	Laminin	HUMAN|HGNC=6485|UniProtKB=O15230	Laminin subunit alpha-5	IPI	2538453	PubMed	PTHR10574:SF261	LAMININ SUBUNIT ALPHA-5
P00010	B cell activation	P00402	Jnk	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	RAT|RGD=2089|UniProtKB=P05065	Fructose-bisphosphate aldolase A	ISS	4812352	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	PANTR|Ensembl=ENSPTRG00000001477|UniProtKB=H2Q0A5	Tyrosine-protein kinase receptor	ISS	12644000	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01177	P110ACT	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01417	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00001	Adrenaline and noradrenaline biosynthesis	P00067	MAO	MACMU|Ensembl=ENSMMUG00000019492|UniProtKB=F7D3H3	Amine oxidase [flavin-containing]	ISS	8602220	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P04393	Ras Pathway	P04547	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	3035212	PubMed	PTHR24070:SF385	GTPASE HRAS
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04393	Ras Pathway	P04541	p90RSK	PANTR|Ensembl=ENSPTRG00000000387|UniProtKB=H2PYE3	Ribosomal protein S6 kinase	ISS	15226426	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	ANOGA|EnsemblGenome=AGAP004613|UniProtKB=Q7Q7P1	AGAP004613-PA (Fragment)	IDA			PTHR43893:SF6	DOPAMINE RECEPTOR 1
P00012	Cadherin signaling pathway	P00470	F-actin	CAEBR|Gene=CBG02161|UniProtKB=A8WS32	Protein CBG02161	ISS	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	DROME|FlyBase=FBgn0000042|UniProtKB=P10987	Actin-5C	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	CHICK|Ensembl=ENSGALG00000016049|UniProtKB=F1P0T9	Uncharacterized protein	ISS			PTHR23409:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	BOVIN|Ensembl=ENSBTAG00000020756|UniProtKB=A6QLB8	GSK3A protein	ISS	11995474	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	BOVIN|Ensembl=ENSBTAG00000015988|UniProtKB=F1MYM9	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF335	MYOSIN-11
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	PANTR|Ensembl=ENSPTRG00000004222|UniProtKB=H2Q4N4	Uncharacterized protein	ISS	8207000	PubMed	PTHR10201:SF165	COLLAGENASE 3
P00034	Integrin signalling pathway	P00944	Actin	HUMAN|HGNC=132|UniProtKB=P60709	Actin, cytoplasmic 1	IPI	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00018	EGF receptor signaling pathway	P00539	14-3-3	BOVIN|Ensembl=ENSBTAG00000000236|UniProtKB=P63103	14-3-3 protein zeta/delta	ISS	92283271	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00053	T cell activation	P01306	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Gene=DRD2|UniProtKB=P20288	D(2) dopamine receptor	IDA	11248120	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00025	Hedgehog signaling pathway	P00687	Cubitus interruptus repressor	XENTR|Xenbase=XB-GENE-484855|UniProtKB=F6XFR9	Uncharacterized protein (Fragment)	ISS	9203143	PubMed	PTHR19818:SF5	TRANSCRIPTIONAL ACTIVATOR GLI3
P02783	Tryptophan biosynthesis	P03210	Indole-3-glycerol phosphate synthase	STRCO|EnsemblGenome=CAB51431|UniProtKB=O68814	Indole-3-glycerol phosphate synthase 1	ISS			PTHR22854:SF2	TRYPTOPHAN BIOSYNTHESIS PROTEIN TRPCF
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IDA			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IC	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00005	Angiogenesis	P00256	PLC-gamma	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	18021322	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P02741	Flavin biosynthesis	P02936	FAD synthetase	AQUAE|EnsemblGenome=aq_139|UniProtKB=O66535	Riboflavin biosynthesis protein	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IGI	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00018	EGF receptor signaling pathway	P00557	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	RAT|RGD=619751|UniProtKB=O88302	Guanine nucleotide-binding protein subunit alpha-15	ISS	8838318	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	3045562	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	THEMA|EnsemblGenome=TM_1255|UniProtKB=Q9X0Y2	Aspartate aminotransferase	ISS			PTHR11751:SF306	SUBFAMILY NOT NAMED
P00059	p53 pathway	G01575	GADD45	RAT|RGD=1311796|UniProtKB=Q9WTQ7	Growth arrest and DNA damage-inducible protein GADD45 gamma	IGI	10097101	PubMed	PTHR10411:SF4	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 GAMMA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IDA	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00047	PDGF signaling pathway	P01153	GSK3	MACMU|Ensembl=ENSMMUG00000014597|UniProtKB=F6VAQ6	Glycogen synthase kinase-3 alpha	ISS	12086949	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	HUMAN|HGNC=3023|UniProtKB=P14416	D(2) dopamine receptor	IDA	11861492	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00034	Integrin signalling pathway	P00936	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IPI	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00054	Toll receptor signaling pathway	P01352	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00005	Angiogenesis	P00223	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00477	GSK3beta	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00057	Wnt signaling pathway	P01435	SWI/SNF	ARATH|TAIR=AT3G01890|UniProtKB=Q147F4	At3g01890	ISS	11532957	PubMed	PTHR13844:SF22	SWI/SNF COMPLEX COMPONENT SNF12 HOMOLOG
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	CAEEL|WormBase=WBGene00004860|UniProtKB=Q09488	Serine/threonine-protein kinase sma-6	TAS	9395284	PubMed	PTHR23255:SF68	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P06587	Nicotine pharmacodynamics pathway	P06605	KCNK3/9	HUMAN|HGNC=6283|UniProtKB=Q9NPC2	Potassium channel subfamily K member 9	RCA	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	HUMAN|HGNC=9993|UniProtKB=O94810	Regulator of G-protein signaling 11	IDA	8756726	PubMed	PTHR10845:SF144	REGULATOR OF G-PROTEIN SIGNALING 11
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	ISS	1650351	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P04398	p53 pathway feedback loops 2	P04667	p21	MACMU|Ensembl=ENSMMUG00000003210|UniProtKB=F7EEK4	Cyclin-dependent kinase inhibitor 1	ISS			PTHR10265:SF16	CYCLIN-DEPENDENT KINASE INHIBITOR 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=19218|UniProtKB=Q86YW0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1	ISS	15611108	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00547	PP2A	BOVIN|Ensembl=ENSBTAG00000009245|UniProtKB=Q0P594	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01296	TCR zeta	BOVIN|Ensembl=ENSBTAG00000012700|UniProtKB=Q0VCU4	CD247 molecule	IGI	9012833	PubMed	PTHR10035:SF2	T-CELL SURFACE GLYCOPROTEIN CD3 ZETA CHAIN
P06209	ALP23B signaling pathway	P06224	SMOX	DROME|FlyBase=FBgn0025800|UniProtKB=O96660	Mothers against decapentaplegic homolog	IEA	9395284	PubMed	PTHR13703:SF25	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00633	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00011	Blood coagulation	P00418	Fibrin monomer	XENTR|Xenbase=XB-GENE-483216|UniProtKB=B0JZ09	Fgb protein	ISS	1160337	gi	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00045	Notch signaling pathway	P01119	NIct	HUMAN|HGNC=7882|UniProtKB=Q04721	Neurogenic locus notch homolog protein 2	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P05915	Opioid proenkephalin pathway	P05994	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00012	Cadherin signaling pathway	P00470	F-actin	DICDI|dictyBase=DDB_G0289489|UniProtKB=P07828	Actin-18	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05915	Opioid proenkephalin pathway	P05994	G-protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00010	B cell activation	P00381	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IGI	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02751	Lysine biosynthesis	P03010	Diaminopimelate epimerase	DICTD|EnsemblGenome=Dtur_0778|UniProtKB=B8DZX7	Diaminopimelate epimerase	RCA			PTHR31689:SF0	DIAMINOPIMELATE EPIMERASE, CHLOROPLASTIC
P02771	Pyrimidine Metabolism	P03129	Aminotransferase	PANTR|Ensembl=ENSPTRG00000007746|UniProtKB=H2QAJ4	4-aminobutyrate aminotransferase	ISS	8133261	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	DAPPU|EnsemblGenome=DAPPUDRAFT_194510|UniProtKB=E9G7U7	Serine/threonine-protein phosphatase (Fragment)	ISS	10433257	PubMed	PTHR11668:SF282	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-BETA CATALYTIC SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CAEBR|Gene=CBG23090|UniProtKB=A8Y4R0	Protein CBG23090	ISS	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	RAT|RGD=1306620|UniProtKB=B1H230	Map2k3 protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04398	p53 pathway feedback loops 2	P04665	AKT	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	ISS	9716402	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00840	GPRK	MOUSE|MGI=MGI=1347078|UniProtKB=O70293	G protein-coupled receptor kinase 6	ISS	12032308	PubMed	PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P00010	B cell activation	P00379	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P06664	Gonadotropin-releasing hormone receptor pathway	G06881	Rap1b	MOUSE|MGI=MGI=894315|UniProtKB=Q99JI6	Ras-related protein Rap-1b	RCA	8576107	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	DICDI|dictyBase=DDB_G0272616|UniProtKB=P42521	Ribonucleoside-diphosphate reductase small subunit	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00060	Ubiquitin proteasome pathway	P01491	E2	MACMU|Ensembl=ENSMMUG00000008069|UniProtKB=F7H158	Ubiquitin-conjugating enzyme E2 E3	ISS			PTHR24068:SF63	UBIQUITIN-CONJUGATING ENZYME E2 E3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00010	B cell activation	P00398	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IGI	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04393	Ras Pathway	P04569	Cdc42	CHICK|Ensembl=ENSGALG00000004796|UniProtKB=Q90694	Cell division control protein 42 homolog	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00047	PDGF signaling pathway	P01171	PLCgamma	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00012	Cadherin signaling pathway	P00475	Frizzled	RAT|RGD=61916|UniProtKB=Q08463	Frizzled-1	IDA	11212302	PubMed	PTHR11309:SF81	FRIZZLED-1
P00018	EGF receptor signaling pathway	P00547	PP2A	RAT|RGD=1585097|UniProtKB=A0A0G2JZD1	Protein Ppp2r5c	ISS	10092233	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	RCA	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=1346347|UniProtKB=Q9WVS8	Mitogen-activated protein kinase 7	IPI	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P02741	Flavin biosynthesis	P02934	Riboflavin kinase	CHLTR|EnsemblGenome=CT_093|UniProtKB=O84095	Riboflavin biosynthesis protein	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00859	NFkappaB	MOUSE|MGI=MGI=97312|UniProtKB=P25799	Nuclear factor NF-kappa-B p105 subunit	IDA	12574369	PubMed	PTHR24169:SF9	NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT
P05731	GABA-B receptor II signaling	P05752	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00035	Interferon-gamma signaling pathway	P00956	SOCS	MACMU|Ensembl=ENSMMUG00000005384|UniProtKB=F7GUL4	Suppressor of cytokine signaling 5	ISS	15032587	PubMed	PTHR44282:SF3	SUPPRESSOR OF CYTOKINE SIGNALING 5
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	DROME|FlyBase=FBgn0004619|UniProtKB=Q03445	Glutamate receptor 1	ISS	10331083	PubMed	PTHR18966:SF270	GLUTAMATE RECEPTOR 1-RELATED
P00010	B cell activation	P00379	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00048	PI3 kinase pathway	P01199	Galpha	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	IC	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00019	Endothelin signaling pathway	P00591	PLCbeta	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00039	Metabotropic glutamate receptor group III pathway	P01038	Vglut	MACMU|Ensembl=ENSMMUG00000014800|UniProtKB=F6W612	Uncharacterized protein	ISS	15192755	PubMed	PTHR11662:SF138	VESICULAR GLUTAMATE TRANSPORTER 1
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01150	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00624	14-3-3	CANAL|CGD=CAL0000198341|UniProtKB=O42766	14-3-3 protein homolog	IGI	21626410	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CANLF|Ensembl=ENSCAFG00000002617|UniProtKB=E2QUL1	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00021	FGF signaling pathway	P00633	Ras	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=2685045|UniProtKB=E9QAN8	Protein Pik3c2b	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P04393	Ras Pathway	P04570	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=69280|UniProtKB=Q9Z1Y3	Cadherin-2	IDA	8120095	PubMed	PTHR24027:SF79	CADHERIN-2
P00048	PI3 kinase pathway	P01188	Gbetagamma	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	XENTR|Xenbase=XB-GENE-969601|UniProtKB=Q28H40	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00057	Wnt signaling pathway	P01435	SWI/SNF	DROME|FlyBase=FBgn0086613|UniProtKB=Q9VDY1	Putative DNA helicase Ino80	ISS	11532957	PubMed	PTHR10799:SF868	DNA HELICASE INO80
P00021	FGF signaling pathway	P00633	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00019	Endothelin signaling pathway	P00591	PLCbeta	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IGI	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MONDO|Ensembl=ENSMODG00000012546|UniProtKB=F6PM16	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00025	Hedgehog signaling pathway	P00682	PKA	STRPU|EnsemblGenome=SPU_018419|UniProtKB=W4YRI6	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=1346347|UniProtKB=Q9WVS8	Mitogen-activated protein kinase 7	IPI	12912994	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00010	B cell activation	P00383	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CANLF|Ensembl=ENSCAFG00000004381|UniProtKB=J9JH96	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P04397	p53 pathway by glucose deprivation	P04641	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00036	Interleukin signaling pathway	P00983	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00049	Parkinson disease	P01236	Casein kinase II	HUMAN|HGNC=2460|UniProtKB=P67870	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00054	Toll receptor signaling pathway	P01375	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02763	Peptidoglycan biosynthesis	P03090	N-Acetylglucosaminyl transferase	FUSNN|EnsemblGenome=FN1457|UniProtKB=Q8R5N5	UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase	ISS			PTHR21015:SF22	GLYCOSYLTRANSFERASE
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	XENTR|Xenbase=XB-GENE-1004978|UniProtKB=F7DUN9	Uncharacterized protein (Fragment)	ISS	11055438	PubMed	PTHR10117:SF56	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9836512	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=19218|UniProtKB=Q86YW0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1	ISS	7822322	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P00015	Circadian clock system	P00502	Casein kinase I	CANLF|Ensembl=ENSCAFG00000006059|UniProtKB=F1Q126	Uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	RAT|RGD=620027|UniProtKB=P08911	Muscarinic acetylcholine receptor M5	IDA	8100450	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00024	Glycolysis	P00679	Aldolase	HUMAN|HGNC=414|UniProtKB=P04075	Fructose-bisphosphate aldolase A	ISS	84261525	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00034	Integrin signalling pathway	P00941	Integrin alpha	PANTR|Ensembl=ENSPTRG00000001204|UniProtKB=H2PZU1	Integrin, alpha 10	ISS	3487386	PubMed	PTHR23220:SF26	INTEGRIN ALPHA-10
P02783	Tryptophan biosynthesis	P03208	Tryptophan synthase B	PYRAE|EnsemblGenome=PAE0257|UniProtKB=Q8ZZH7	Tryptophan synthase beta subunit (TrpB), authentic frameshift	ISS			PTHR43565:SF1	TRYPTOPHAN SYNTHASE BETA CHAIN
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	HUMAN|HGNC=9871|UniProtKB=P20936	Ras GTPase-activating protein 1	TAS	8270251	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00021	FGF signaling pathway	P00640	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	ISS	12660731	PubMed	PTHR10048:SF14	PI-3 KINASE
P00034	Integrin signalling pathway	P00924	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IPI	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=102705|UniProtKB=P63213	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	IC			PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	RCA	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	PYRAE|EnsemblGenome=PAE3155|UniProtKB=Q8ZTP7	Ribonucleotide reductase	ISS			PTHR43371:SF1	SUBFAMILY NOT NAMED
P00060	Ubiquitin proteasome pathway	P01491	E2	MONDO|Ensembl=ENSMODG00000011783|UniProtKB=F7CC81	Uncharacterized protein	ISS			PTHR24068:SF40	UBIQUITIN-CONJUGATING ENZYME E2 D2-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00045	Notch signaling pathway	P01105	TACE	CANLF|Ensembl=ENSCAFG00000003383|UniProtKB=F1PFZ9	Uncharacterized protein	ISS	12834808	PubMed	PTHR11905:SF171	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17
P00057	Wnt signaling pathway	P01465	Ggamma	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00321	HSP70	SCHMA|EnsemblGenome=Smp_106930|UniProtKB=G4V8L4	Putative heat shock protein 70	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00006	Apoptosis signaling pathway	P00321	HSP70	MONDO|Ensembl=ENSMODG00000012958|UniProtKB=F7DC98	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF239	HEAT SHOCK COGNATE 71 KDA PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00048	PI3 kinase pathway	P01179	PKB	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	TAS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00839	SHIP	BOVIN|Ensembl=ENSBTAG00000019167|UniProtKB=E1BBJ7	Uncharacterized protein	ISS	10381377	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=1759|UniProtKB=P19022	Cadherin-2	ISS	8120095	PubMed	PTHR24027:SF79	CADHERIN-2
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	SCHPO|PomBase=SPAC8C9.03|UniProtKB=P36600	cAMP-dependent protein kinase regulatory subunit	ISS	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01185	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00006	Apoptosis signaling pathway	P00269	MAPK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	HUMAN|HGNC=5295|UniProtKB=P28335	5-hydroxytryptamine receptor 2C	ISS	11859080	PubMed	PTHR24247:SF32	5-HYDROXYTRYPTAMINE RECEPTOR 2C
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	HUMAN|HGNC=16257|UniProtKB=Q9H4B7	Tubulin beta-1 chain	ISS	12932731	PubMed	PTHR11588:SF112	TUBULIN BETA-1 CHAIN
P00034	Integrin signalling pathway	P00941	Integrin alpha	MACMU|Ensembl=ENSMMUG00000003755|UniProtKB=F7GXE0	Uncharacterized protein	ISS	3487386	PubMed	PTHR23220:SF3	INTEGRIN ALPHA-5
P00029	Huntington disease	P00807	Actin	CAEEL|WormBase=WBGene00000067|UniProtKB=O45815	ACTin	IDA	11889126	PubMed	PTHR11937:SF352	ACTIN
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	METAC|EnsemblGenome=MA_1524|UniProtKB=Q8TQL6	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	HUMAN|HGNC=7883|UniProtKB=Q9UM47	Neurogenic locus notch homolog protein 3	IDA	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00006	Apoptosis signaling pathway	P00313	IKK	PANTR|Ensembl=ENSPTRG00000020202|UniProtKB=H2QW34	Uncharacterized protein	ISS	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00034	Integrin signalling pathway	P00927	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12874273	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04398	p53 pathway feedback loops 2	G04714	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	CAEEL|WormBase=WBGene00000295|UniProtKB=Q9GNP0	Uncharacterized protein	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	PANTR|Ensembl=ENSPTRG00000024064|UniProtKB=H2R3R2	Synaptotagmin I	ISS	1840599	PubMed	PTHR10024:SF239	SYNAPTOTAGMIN-1
P02773	S-adenosylmethionine biosynthesis	P03142	Cobalamin-dependent homocysteine transmethylase	MOUSE|MGI=MGI=894292|UniProtKB=A6H5Y3	Methionine synthase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P05731	GABA-B receptor II signaling	P05754	Ggamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00047	PDGF signaling pathway	P01173	STAT	BOVIN|Gene=STAT5A|UniProtKB=Q95115	Signal transducer and activator of transcription 5A	ISS	14662325	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014262|UniProtKB=F7BYS8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	IDA	18021322	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CHICK|Ensembl=ENSGALG00000009287|UniProtKB=O93602	Cyclic AMP-dependent transcription factor ATF-2	TAS	9819389	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00059	p53 pathway	P04616	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	15531926	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P02765	Phenylalanine biosynthesis	P03099	Prephenate dehydratase	DEIRA|EnsemblGenome=DR_1147|UniProtKB=Q9RV82	Bifunctional chorismate mutase/prephenate dehydratase	ISS			PTHR21022:SF0	PREPHENATE DEHYDRATASE-RELATED
P00057	Wnt signaling pathway	P01451	Galpha	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	IDA	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00029	Huntington disease	P00805	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02728	Arginine biosynthesis	P02846	Ornithine carbamoyl transferase	PYRAE|EnsemblGenome=PAE1985|UniProtKB=Q8ZW40	Ornithine carbamoyltransferase	ISS			PTHR11405:SF1	ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL
P02751	Lysine biosynthesis	P03009	Aspartokinase	ARATH|TAIR=AT5G13280|UniProtKB=Q9LYU8	Aspartokinase 1, chloroplastic	ISS			PTHR21499:SF38	ASPARTOKINASE 1, CHLOROPLASTIC
P00013	Cell cycle	P00480	Proteasome	MOUSE|MGI=MGI=1096366|UniProtKB=P61290	Proteasome activator complex subunit 3	ISS	9218537	PubMed	PTHR10660:SF4	PROTEASOME ACTIVATOR COMPLEX SUBUNIT 3
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MACMU|Ensembl=ENSMMUG00000017683|UniProtKB=F6UA63	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00053	T cell activation	P01311	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	XENTR|Xenbase=XB-GENE-5919679|UniProtKB=F6WET9	Uncharacterized protein	ISS			PTHR43893:SF11	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	RCA	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PANTR|Ensembl=ENSPTRG00000014309|UniProtKB=H2QLK6	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF317	MYOSIN-9
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00052	TGF-beta signaling pathway	P01275	P38	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	TAS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	MACMU|Ensembl=ENSMMUG00000001387|UniProtKB=F7D0B4	Uncharacterized protein	ISS	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00015	Circadian clock system	P00505	Cry	MOUSE|MGI=MGI=1270841|UniProtKB=P97784	Cryptochrome-1	IDA	14507900	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00059	p53 pathway	G01579	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00014	Cholesterol biosynthesis	P00492	Mevalonate kinase	PANTR|Ensembl=ENSPTRG00000005428|UniProtKB=H2Q6U7	Mevalonate kinase	ISS	9392419	PubMed	PTHR43290:SF2	MEVALONATE KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	8649368	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IC	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00807	Actin	RAT|RGD=1309504|UniProtKB=D3ZRN3	Protein Actbl2	ISS	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00018	EGF receptor signaling pathway	P00565	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IGI	10395542	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00036	Interleukin signaling pathway	P00970	Interleukin	RAT|RGD=2886|UniProtKB=P29456	Interleukin-10	IC			PTHR44875:SF1	INTERLEUKIN-10
P00057	Wnt signaling pathway	P01468	APC	BOVIN|Ensembl=ENSBTAG00000018852|UniProtKB=F1MV51	Uncharacterized protein	ISS	12549854	PubMed	PTHR12607:SF11	ADENOMATOUS POLYPOSIS COLI PROTEIN
P00012	Cadherin signaling pathway	P00470	F-actin	CAEEL|WormBase=WBGene00000200|UniProtKB=P53489	Actin-related protein 2	ISS	10974003	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00084	X11alpha	PANTR|Ensembl=ENSPTRG00000010275|UniProtKB=H2QEZ6	Amyloid beta (A4) protein-binding, family A, member 3	ISS	9614075	PubMed	PTHR12345:SF9	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 3
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	RAT|RGD=1308582|UniProtKB=Q5U3Z7	Serine hydroxymethyltransferase	ISS			PTHR11680:SF17	SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00878	INFgamma	CANLF|Ensembl=ENSCAFG00000000408|UniProtKB=P42161	Interferon gamma	TAS	11175845	PubMed	PTHR11419:SF0	INTERFERON GAMMA
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CHICK|Ensembl=ENSGALG00000006638|UniProtKB=R4GGL9	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00011	Blood coagulation	P00445	FXa	ORNAN|Ensembl=ENSOANG00000015639|UniProtKB=F7FYL8	Uncharacterized protein	ISS	9837158	gi	PTHR44064:SF3	COAGULATION FACTOR X
P05916	Opioid prodynorphin pathway	P06002	G-protein	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	TAS	10995439	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	TAS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00629	PP2A	DICDI|dictyBase=DDB_G0283905|UniProtKB=Q54Q99	Serine/threonine-protein phosphatase 2A regulatory subunit phr2AB	NAS			PTHR11871:SF0	PROTEIN PHOSPHATASE PP2A 55 KDA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00648	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	ARATH|TAIR=AT1G13890|UniProtKB=Q9LMG8	Putative SNAP25 homologous protein SNAP30	IC			PTHR19305:SF7	SNAP25 HOMOLOGOUS PROTEIN SNAP30-RELATED
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00059	p53 pathway	P01486	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00011	Blood coagulation	P00424	uPA	CHICK|Gene=PLAU|UniProtKB=P15120	Urokinase-type plasminogen activator	ISS	137111	gi	PTHR44246:SF2	UROKINASE-TYPE PLASMINOGEN ACTIVATOR
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00036	Interleukin signaling pathway	P00976	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00018	EGF receptor signaling pathway	P00561	STAT	HUMAN|HGNC=11363|UniProtKB=P52630	Signal transducer and activator of transcription 2	ISS			PTHR11801:SF41	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 2
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P02775	Salvage pyrimidine ribonucleotides	P03156	CDP kinase	ARATH|TAIR=AT4G26510|UniProtKB=O65583	Uridine kinase-like protein 4	ISS			PTHR10285:SF97	URIDINE KINASE-LIKE PROTEIN 3-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00053	T cell activation	P01322	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	15572354	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00005	Angiogenesis	P00182	p38MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	MOUSE|MGI=MGI=97355|UniProtKB=P15532	Nucleoside diphosphate kinase A	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DROME|FlyBase=FBgn0000043|UniProtKB=P02572	Actin-42A	ISS	10974003	PubMed	PTHR11937:SF369	ACTIN-42A
P04393	Ras Pathway	P04567	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	XENTR|Xenbase=XB-GENE-494200|UniProtKB=F7CS79	Uncharacterized protein	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IGI	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	MONDO|Ensembl=ENSMODG00000003244|UniProtKB=F6THF0	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000024992|UniProtKB=F6TUR3	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00057	Wnt signaling pathway	P01444	Wnt	CAEEL|WormBase=WBGene00000857|UniProtKB=P34888	Protein Wnt-1	ISS	8717036	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	MOUSE|MGI=MGI=96432|UniProtKB=P05017	Insulin-like growth factor I	ISS			PTHR11454:SF4	INSULIN-LIKE GROWTH FACTOR I
P00057	Wnt signaling pathway	P01428	Frizzled	MONDO|Ensembl=ENSMODG00000006737|UniProtKB=F7CDC6	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF90	FRIZZLED-8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	6264430	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	TAS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00013	Cell cycle	P00484	Cyclin D	PANTR|Ensembl=ENSPTRG00000004549|UniProtKB=H2Q584	Cyclin D2	ISS	93275661	PubMed	PTHR10177:SF66	G1/S-SPECIFIC CYCLIN-D2
P00019	Endothelin signaling pathway	P00567	PKG	MACMU|Ensembl=ENSMMUG00000010844|UniProtKB=F7G3L7	cGMP-dependent protein kinase	ISS	9099696	PubMed	PTHR24353:SF68	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00010	B cell activation	P00391	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01332	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_115566|UniProtKB=C3XYC8	Putative uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	TAKRU|Ensembl=ENSTRUG00000007989|UniProtKB=P68140	Actin, alpha skeletal muscle A	IC	14684598	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00059	p53 pathway	G04702	p53	MACMU|Ensembl=ENSMMUG00000008639|UniProtKB=P56424	Cellular tumor antigen p53	TAS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00053	T cell activation	P01300	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MONDO|Ensembl=ENSMODG00000018065|UniProtKB=F7G485	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	ORNAN|Ensembl=ENSOANG00000004058|UniProtKB=F6TYP9	Uncharacterized protein	ISS	20112749	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00005	Angiogenesis	P00206	Wnt	TAKRU|Ensembl=ENSTRUG00000017138|UniProtKB=H2V3X9	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P02785	Valine biosynthesis	P03218	Dihydroxy isovalerate dehydratase	STRCO|EnsemblGenome=CAB42671|UniProtKB=O69198	Dihydroxy-acid dehydratase	ISS			PTHR43661:SF3	DIHYDROXY-ACID DEHYDRATASE
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	MOUSE|MGI=MGI=94890|UniProtKB=P00375	Dihydrofolate reductase	ISS			PTHR22778:SF16	DIHYDROFOLATE REDUCTASE
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01150	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	PANTR|Ensembl=ENSPTRG00000008771|UniProtKB=H2QCA0	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF484	MYOSIN-1
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	RAT|RGD=621060|UniProtKB=O88777	Presenilin-2	IDA	9332390	PubMed	PTHR10202:SF13	PRESENILIN-2
P00049	Parkinson disease	P01208	Hsp70	BOVIN|Ensembl=ENSBTAG00000039035|UniProtKB=F1MWU9	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF168	HEAT SHOCK 70 KDA PROTEIN 6-RELATED
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00046	Oxidative stress response	P01126	ATF2	CANLF|Ensembl=ENSCAFG00000013332|UniProtKB=F1PCQ4	Uncharacterized protein	ISS	10207617	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00037	Ionotropic glutamate receptor pathway	P01026	KA	CANLF|Ensembl=ENSCAFG00000003333|UniProtKB=F1PWT6	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00006	Apoptosis signaling pathway	P00260	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00397	IKK	MOUSE|MGI=MGI=1338071|UniProtKB=O88351	Inhibitor of nuclear factor kappa-B kinase subunit beta	IGI	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00551	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	BACSU|EnsemblGenome=BSU25300|UniProtKB=P19079	Cytidine deaminase	ISS			PTHR11644:SF16	SUBFAMILY NOT NAMED
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	PANTR|Ensembl=ENSPTRG00000000932|UniProtKB=H2PZC5	General transcription factor IIB	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	XENTR|Ensembl=ENSXETG00000030140|UniProtKB=F7EP58	Uncharacterized protein (Fragment)	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02781	Threonine biosynthesis	P03189	Aspartate kinase	NEUCR|EnsemblGenome=EFNCRG00000003951|UniProtKB=Q1K7N1	Aspartokinase	ISS			PTHR21499:SF3	ASPARTOKINASE
P00049	Parkinson disease	P01211	ERK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	IDA	12787066	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	MOUSE|MGI=MGI=88548|UniProtKB=P67871	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	CHICK|Ensembl=ENSGALG00000013785|UniProtKB=E1BS74	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00005	Angiogenesis	P00253	Axin	CANLF|Ensembl=ENSCAFG00000011236|UniProtKB=E2R9F8	Uncharacterized protein	ISS	12356903	PubMed	PTHR10845:SF103	AXIN-2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04570	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01140	ELK	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	ISS	12660819	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00005	Angiogenesis	P00203	Erk	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04567	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IDA	7937853	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00052	TGF-beta signaling pathway	P01284	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00053	T cell activation	P01332	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	IDA	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05915	Opioid proenkephalin pathway	P05993	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04393	Ras Pathway	P04574	PLD	MOUSE|MGI=MGI=109585|UniProtKB=Q9Z280	Phospholipase D1	IDA	10497874	PubMed	PTHR18896:SF57	PHOSPHOLIPASE D1
P00006	Apoptosis signaling pathway	P00317	Fos	MACMU|Ensembl=ENSMMUG00000010574|UniProtKB=A5A6H2	C-fos	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01181	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT2G43790|UniProtKB=Q39026	Mitogen-activated protein kinase 6	ISS	9836510	gi	PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P00005	Angiogenesis	P00219	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CANLF|Ensembl=ENSCAFG00000002617|UniProtKB=E2QUL1	Uncharacterized protein	ISS	14698601	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00056	VEGF signaling pathway	P01411	Ras	DICPU|Gene=DICPUDRAFT_92731|UniProtKB=F0ZWE6	Putative uncharacterized protein rasG	ISS	7997267	PubMed	PTHR24070:SF282	RAS GTPASE-RELATED
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	PANTR|Ensembl=ENSPTRG00000017182|UniProtKB=H2RAT8	Casein kinase 1, gamma 3	ISS	11437445	PubMed	PTHR11909:SF151	CASEIN KINASE I ISOFORM GAMMA-3
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	ARATH|TAIR=AT1G13890|UniProtKB=Q9LMG8	Putative SNAP25 homologous protein SNAP30	IC			PTHR19305:SF7	SNAP25 HOMOLOGOUS PROTEIN SNAP30-RELATED
P00059	p53 pathway	P04609	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	1171954	gi	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00029	Huntington disease	P00805	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	DICPU|Gene=DICPUDRAFT_47179|UniProtKB=F0ZI47	Putative uncharacterized protein rasB	ISS	7997267	PubMed	PTHR24070:SF206	RAS-LIKE PROTEIN RASB
P00029	Huntington disease	P00786	ARF	XENTR|Xenbase=XB-GENE-968852|UniProtKB=Q6P7Z6	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF294	ADP-RIBOSYLATION FACTOR 3
P02769	Purine metabolism	P03117	5'-AMP Deaminase	HUMAN|HGNC=470|UniProtKB=Q01432	AMP deaminase 3	ISS	1420359	PubMed	PTHR11359:SF2	AMP DEAMINASE 3
P00019	Endothelin signaling pathway	P00566	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	10755300	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	DANRE|ZFIN=ZDB-GENE-991119-4|UniProtKB=Q9W6T7	Presenilin-1	IDA	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00029	Huntington disease	P00811	Arp2/3 complex	MOUSE|MGI=MGI=1343142|UniProtKB=Q9WV32	Actin-related protein 2/3 complex subunit 1B	TAS	12473693	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00019	Endothelin signaling pathway	P00577	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	11292874	PubMed	PTHR10048:SF14	PI-3 KINASE
P02752	Mannose metabolism	P03018	Mannose 1-P guanylyl transferase	RAT|RGD=1560644|UniProtKB=Q5XIC1	Mannose-1-phosphate guanyltransferase alpha	IEA	12477932	PubMed	PTHR22572:SF104	MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE ALPHA
P00045	Notch signaling pathway	P01111	LNXp80	MACMU|Ensembl=ENSMMUG00000011419|UniProtKB=F6VRZ0	Ligand of Numb protein X 2	ISS			PTHR19964:SF33	LIGAND OF NUMB PROTEIN X 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	MOUSE|MGI=MGI=1338071|UniProtKB=O88351	Inhibitor of nuclear factor kappa-B kinase subunit beta	IDA	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008422|UniProtKB=F6VUT7	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00059	p53 pathway	P04633	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	IDA	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01440	Cadherin	BOVIN|Ensembl=ENSBTAG00000014169|UniProtKB=E1BDF9	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF40	PROTOCADHERIN-19
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	IXOSC|EnsemblGenome=ISCW021482|UniProtKB=B7Q717	Beta-tubulin, putative (Fragment)	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00005	Angiogenesis	P00219	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	11591316	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05959	FLNA	MOUSE|MGI=MGI=95556|UniProtKB=Q8BTM8	Filamin-A	ISS	9722563	PubMed	PTHR43998:SF6	FILAMIN-A
P00018	EGF receptor signaling pathway	P00561	STAT	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	ISS	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00047	PDGF signaling pathway	P01173	STAT	PANTR|Ensembl=ENSPTRG00000009200|UniProtKB=H2QD20	Signal transducer and activator of transcription	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00057	Wnt signaling pathway	P01438	PP2A	BOVIN|Ensembl=ENSBTAG00000019784|UniProtKB=A4FV68	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	ISS	11007767	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P04393	Ras Pathway	P04556	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00021	FGF signaling pathway	P00631	Grb2	CAEEL|WormBase=WBGene00004774|UniProtKB=P29355	Sex muscle abnormal protein 5	IPI	17569445	gi	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00006	Apoptosis signaling pathway	P00259	TNF	RAT|RGD=3876|UniProtKB=P16599	Tumor necrosis factor	ISS	8879212	PubMed	PTHR11471:SF23	TUMOR NECROSIS FACTOR
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2846|UniProtKB=P28564	5-hydroxytryptamine receptor 1B	IDA	11454663	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00629	PP2A	PANTR|Ensembl=ENSPTRG00000017238|UniProtKB=H2QRH7	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P02788	Xanthine and guanine salvage pathway	P03247	Xanthine phosphoribosyl transferase	BACSU|EnsemblGenome=BSU00680|UniProtKB=P37472	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00049	Parkinson disease	P01242	Casein kinase I	PLAF7|EnsemblGenome=PF11_0377|UniProtKB=Q8IHZ9	Casein kinase I	IDA	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00010	B cell activation	P00398	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00023	General transcription regulation	P00668	TFIIB	DROME|FlyBase=FBgn0004915|UniProtKB=P29052	Transcription initiation factor IIB	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P00048	PI3 kinase pathway	P01188	Gbetagamma	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P02785	Valine biosynthesis	P03215	Branched chain amino acid aminotransferase	BACSU|EnsemblGenome=BSU38550|UniProtKB=P39576	Branched-chain-amino-acid aminotransferase 2	ISS			PTHR11825:SF44	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P00005	Angiogenesis	P00247	Tie2	BOVIN|Ensembl=ENSBTAG00000020148|UniProtKB=Q06807	Angiopoietin-1 receptor	ISS	1630810	PubMed	PTHR24416:SF125	ANGIOPOIETIN-1 RECEPTOR
P00029	Huntington disease	P00811	Arp2/3 complex	PANTR|Ensembl=ENSPTRG00000033819|UniProtKB=H2QV00	Actin related protein 2/3 complex, subunit 1A, 41kDa	ISS	12932731	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	TAS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	MOUSE|MGI=MGI=96433|UniProtKB=Q60751	Insulin-like growth factor 1 receptor	ISS	6754360	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MOUSE|MGI=MGI=88397|UniProtKB=Q9ERZ4	Muscarinic acetylcholine receptor M2	TAS	10069496	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CANLF|Ensembl=ENSCAFG00000005662|UniProtKB=E2R907	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00476	Yes	PANTR|Ensembl=ENSPTRG00000020263|UniProtKB=H2R453	Tyrosine-protein kinase	ISS			PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	1499560	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00049	Parkinson disease	P01238	14-3-3	ORYSJ|EnsemblGenome=OS01G0209200|UniProtKB=Q5QNB8	14-3-3-like protein GF14-G	IDA	10407019	PubMed	PTHR18860:SF32	14-3-3 FAMILY PROTEIN-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	8170357	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04393	Ras Pathway	P04570	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01297	MEKK	MACMU|Ensembl=ENSMMUG00000012387|UniProtKB=F7EB20	Uncharacterized protein	RCA	12168099	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00034	Integrin signalling pathway	P00922	Collagen	MACMU|Ensembl=ENSMMUG00000023398|UniProtKB=F7FE35	Uncharacterized protein	ISS	10778855	PubMed	PTHR24023:SF372	COLLAGEN ALPHA-1 XVI  CHAIN
P02768	Proline biosynthesis	P03114	Glutamyl kinase	PSEAE|EnsemblGenome=PA4565|UniProtKB=Q9HVL9	Glutamate 5-kinase	ISS			PTHR43654:SF3	GLUTAMATE 5-KINASE
P00048	PI3 kinase pathway	P01202	p85	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04397	p53 pathway by glucose deprivation	P04641	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	20855874	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00990	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00011	Blood coagulation	P00412	PS	BOVIN|Ensembl=ENSBTAG00000023652|UniProtKB=P07224	Vitamin K-dependent protein S	IDA	86168236	PubMed	PTHR24040:SF0	VITAMIN K-DEPENDENT PROTEIN S
P00010	B cell activation	P00371	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00981	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00021	FGF signaling pathway	P00648	PKC	YEAST|SGD=S000000201|UniProtKB=P24583	Protein kinase C-like 1	IGI	125549	gi	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	PANTR|Ensembl=ENSPTRG00000004519|UniProtKB=H2Q569	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00005	Angiogenesis	P00218	STAT1	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	ISS	12191995	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00029	Huntington disease	P00811	Arp2/3 complex	CANLF|Ensembl=ENSCAFG00000015081|UniProtKB=E2RMT4	Uncharacterized protein	ISS	12473693	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	HUMAN|HGNC=9509|UniProtKB=P49810	Presenilin-2	IDA	12846562	PubMed	PTHR10202:SF13	PRESENILIN-2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00010	B cell activation	P00371	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	XENTR|Xenbase=XB-GENE-5733929|UniProtKB=Q6P647	Casein kinase I isoform delta	ISS	10617630	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00019	Endothelin signaling pathway	P00586	Gq	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00029	Huntington disease	G01535	PIG3	STRCO|Gene=CAB46946|UniProtKB=Q9XA55	Putative quinone oxidoreductase	TAS	12932731	PubMed	PTHR43006:SF6	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01412	HSP27	MONDO|Ensembl=ENSMODG00000014453|UniProtKB=F7ATA8	Uncharacterized protein	ISS			PTHR11527:SF37	ALPHA-CRYSTALLIN B CHAIN
P00022	General transcription by RNA polymerase I	P00657	TBP	CAEEL|WormBase=WBGene00006577|UniProtKB=B2D6P4	TBP-Like Factor	ISS	600075	OMIM	PTHR10126:SF13	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	PSEAE|EnsemblGenome=PA4938|UniProtKB=Q9HUM6	Adenylosuccinate synthetase	IEP	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00053	T cell activation	P01310	Lck	HUMAN|HGNC=6524|UniProtKB=P06239	Tyrosine-protein kinase Lck	IGI	1505025	PubMed	PTHR24418:SF39	TYROSINE-PROTEIN KINASE LCK
P00018	EGF receptor signaling pathway	P00564	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	IPI	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00010	B cell activation	P00402	Jnk	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	RAT|RGD=2746|UniProtKB=P31424	Metabotropic glutamate receptor 5	ISS	14614461	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00012	Cadherin signaling pathway	P00470	F-actin	USTMA|Gene=UMAG_11232|UniProtKB=A0A0D1DMT3	Chromosome 22, whole genome shotgun sequence	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00007	Axon guidance mediated by semaphorins	P00337	Sema3A	PANTR|Ensembl=ENSPTRG00000019354|UniProtKB=H2QUV1	Uncharacterized protein	ISS			PTHR11036:SF23	SEMAPHORIN-3A
P00029	Huntington disease	P00780	Microtubule	CANLF|Ensembl=ENSCAFG00000018634|UniProtKB=E2RFV2	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF253	TUBULIN BETA-4A CHAIN
P00019	Endothelin signaling pathway	P00582	COX-2	CANLF|Ensembl=ENSCAFG00000013762|UniProtKB=Q8SPQ9	Cyclooxygenase 2	IGI	11861541	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P04375	5HT3 type receptor mediated signaling pathway	P04425	K+ channel	MONDO|Ensembl=ENSMODG00000015769|UniProtKB=F6ZSC2	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00036	Interleukin signaling pathway	P00965	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IC	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	HUMAN|HGNC=1392|UniProtKB=Q15878	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	14624853	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00047	PDGF signaling pathway	P01160	IP3 receptor	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00059	p53 pathway	G04694	p110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04548	ATF2	BOVIN|Ensembl=ENSBTAG00000002295|UniProtKB=F1N177	Uncharacterized protein	ISS	7875593	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00010	B cell activation	P00402	Jnk	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00127	APP	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00059	p53 pathway	P04609	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	ISS	11554549	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	BOVIN|Ensembl=ENSBTAG00000007882|UniProtKB=G3X7Z2	Uncharacterized protein	ISS	11976940	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	CANLF|Ensembl=ENSCAFG00000011846|UniProtKB=E2QRQ8	Uncharacterized protein	ISS			PTHR43097:SF4	GLUTAMINE--TRNA LIGASE-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-9966|UniProtKB=Q6TH03	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04398	p53 pathway feedback loops 2	G04714	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	IGI	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00018	EGF receptor signaling pathway	P00545	JNK1-3	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IGI	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	BOVIN|Ensembl=ENSBTAG00000010111|UniProtKB=F1MJS2	Uncharacterized protein	ISS	11266476	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347742|UniProtKB=E9FZ00	Cytoplasmatic actin	ISS	10974003	PubMed	PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PANTR|Ensembl=ENSPTRG00000009762|UniProtKB=H2QE24	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MACMU|Ensembl=ENSMMUG00000007486|UniProtKB=F6QL95	Frizzled-3	ISS	12549854	PubMed	PTHR11309:SF22	FRIZZLED-3
P05731	GABA-B receptor II signaling	P05752	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	XENTR|Xenbase=XB-GENE-956713|UniProtKB=Q5XGD8	Guanine nucleotide binding protein, beta 3	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00024	Glycolysis	P00678	Enolase	CHICK|Gene=ENO2|UniProtKB=O57391	Gamma-enolase	ISS	5803011	gi	PTHR11902:SF10	GAMMA-ENOLASE
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	BOVIN|Ensembl=ENSBTAG00000015988|UniProtKB=F1MYM9	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF335	MYOSIN-11
P00019	Endothelin signaling pathway	P00568	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	7492337	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00034	Integrin signalling pathway	P00923	Arf1	CHICK|Ensembl=ENSGALG00000005393|UniProtKB=F1NN08	Uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF234	ADP-RIBOSYLATION FACTOR 1
P05913	Enkephalin release	P05978	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00005	Angiogenesis	P00203	Erk	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CANLF|Ensembl=ENSCAFG00000016020|UniProtKB=O18840	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00013	Cell cycle	P00481	APC	MONDO|Ensembl=ENSMODG00000000439|UniProtKB=F6UT46	Anaphase-promoting complex subunit 10	ISS	14732115	gi	PTHR12936:SF0	ANAPHASE-PROMOTING COMPLEX SUBUNIT 10
P04393	Ras Pathway	P04567	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	IDA	10514528	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P05916	Opioid prodynorphin pathway	P06002	G-protein	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00034	Integrin signalling pathway	P00927	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	15470041	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00047	PDGF signaling pathway	P01173	STAT	MONDO|Ensembl=ENSMODG00000014836|UniProtKB=F7D2D3	Signal transducer and activator of transcription	ISS	96102059	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P02723	Adenine and hypoxanthine salvage pathway	P02808	Deoxyadenosine phosphorylase	HUMAN|HGNC=7892|UniProtKB=P00491	Purine nucleoside phosphorylase	ISS			PTHR11904:SF12	PURINE NUCLEOSIDE PHOSPHORYLASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	DICDI|dictyBase=DDB_G0277143|UniProtKB=P36408	Guanine nucleotide-binding protein subunit beta	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00049	Parkinson disease	P01238	14-3-3	XENTR|Xenbase=XB-GENE-996375|UniProtKB=F7DY42	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00006	Apoptosis signaling pathway	P00269	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P02759	Pyridoxal-5-phosphate biosynthesis	P03061	Pyridoxine-5-phosphate oxidase	MACMU|Ensembl=ENSMMUG00000003325|UniProtKB=F7EHD9	Pyridoxine-5'-phosphate oxidase	ISS	9601034	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00048	PI3 kinase pathway	P01199	Galpha	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	IC	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00235	c-Fos	MACMU|Ensembl=ENSMMUG00000010574|UniProtKB=A5A6H2	C-fos	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00056	VEGF signaling pathway	P01413	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00627	ERK1-2	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IGI	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01142	p90RSK	BOVIN|Ensembl=ENSBTAG00000017639|UniProtKB=F1MZW8	Ribosomal protein S6 kinase	ISS	10558991	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P04393	Ras Pathway	P04552	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	HUMAN|HGNC=4616|UniProtKB=P49840	Glycogen synthase kinase-3 alpha	IDA	21361340	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00012	Cadherin signaling pathway	P00462	Casein kinase II	PANTR|Ensembl=ENSPTRG00000013147|UniProtKB=H2QJS7	Uncharacterized protein	ISS	10806215	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00021	FGF signaling pathway	P00642	MEK1-2	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00046	Oxidative stress response	P01131	MKP5	XENTR|Xenbase=XB-GENE-978216|UniProtKB=Q28E94	Dual specificity protein phosphatase	ISS			PTHR10159:SF45	DUAL SPECIFICITY PROTEIN PHOSPHATASE 6
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00590	IP3 R	CAEBR|Gene=CBG_05938|UniProtKB=H8WGV2	Protein CBR-ITR-1, isoform a	ISS	1849282	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	PANTR|Ensembl=ENSPTRG00000019617|UniProtKB=Q2QLE7	Protein Wnt-2	ISS	11266476	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00056	VEGF signaling pathway	P01417	Raf	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00059	p53 pathway	P01486	Akt	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	TAS	12655147	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00373	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	RCA	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00037	Ionotropic glutamate receptor pathway	P01021	Vglut	MOUSE|MGI=MGI=3039629|UniProtKB=Q8BFU8	Vesicular glutamate transporter 3	ISS	12815758	PubMed	PTHR11662:SF207	VESICULAR GLUTAMATE TRANSPORTER 3
P00012	Cadherin signaling pathway	P00467	alpha-catenin	DANRE|ZFIN=ZDB-GENE-991207-24|UniProtKB=Q9PVF8	Catenin (Cadherin-associated protein), alpha	IDA	9362521	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00060	Ubiquitin proteasome pathway	P01490	E3	HUMAN|HGNC=13890|UniProtKB=Q96J02	E3 ubiquitin-protein ligase Itchy homolog	ISS			PTHR11254:SF66	E3 UBIQUITIN-PROTEIN LIGASE ITCHY HOMOLOG
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	ISS	2372396	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	PLAF7|EnsemblGenome=PF14_0425|UniProtKB=Q7KQL9	Fructose-bisphosphate aldolase	TAS	5911416	gi	PTHR11627:SF20	FRUCTOSE-BISPHOSPHATE ALDOLASE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	MACMU|Ensembl=ENSMMUG00000011434|UniProtKB=F7BA66	Pyrroline-5-carboxylate reductase	ISS			PTHR11645:SF4	PYRROLINE-5-CARBOXYLATE REDUCTASE 2
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00015	Circadian clock system	G01501	cry	RAT|RGD=620935|UniProtKB=Q923I8	Cryptochrome-2	IDA	10428031	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	HUMAN|HGNC=1951|UniProtKB=P08172	Muscarinic acetylcholine receptor M2	IDA			PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CHICK|Ensembl=ENSGALG00000004083|UniProtKB=Q90855	AMPA receptor GluR1/A	ISS	10331083	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00036	Interleukin signaling pathway	P00987	SRF	PANTR|Ensembl=ENSPTRG00000018189|UniProtKB=H2QT21	Uncharacterized protein	ISS	15170389	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	PANTR|Ensembl=ENSPTRG00000003041|UniProtKB=H2Q2R2	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF147	MATRIX METALLOPROTEINASE-21
P02776	Serine glycine biosynthesis	P03157	Phosphoserine aminotransferase	YEAST|SGD=S000005710|UniProtKB=P33330	Phosphoserine aminotransferase	ISS	9169874	PubMed	PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	TAKRU|Ensembl=ENSTRUG00000004787|UniProtKB=P53480	Actin, alpha cardiac	ISS	14684598	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=11330|UniProtKB=P30872	Somatostatin receptor type 1	IDA	12181435	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P00005	Angiogenesis	P00237	FRP	HUMAN|HGNC=4038|UniProtKB=Q9UP38	Frizzled-1	IC	8717036	PubMed	PTHR11309:SF81	FRIZZLED-1
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00046	Oxidative stress response	P01138	MKK4	MONDO|Ensembl=ENSMODG00000008266|UniProtKB=F6Z879	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04396	Vitamin D metabolism and pathway	P04602	RXR	MOUSE|MGI=MGI=97856|UniProtKB=P11416	Retinoic acid receptor alpha	TAS			PTHR24082:SF115	RETINOIC ACID RECEPTOR ALPHA
P00056	VEGF signaling pathway	P01407	Erk	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00629	PP2A	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	88248000	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01161	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01236	Casein kinase II	ORYSJ|EnsemblGenome=OS03G0207300|UniProtKB=Q10Q71	Casein kinase II, alpha chain, putative, expressed	IDA	10806215	PubMed	PTHR24054:SF35	SUBFAMILY NOT NAMED
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	DICDI|dictyBase=DDB_G0276821|UniProtKB=P83401	Putative aldehyde dehydrogenase family 7 member A1 homolog	IC			PTHR43521:SF1	ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	ANOGA|EnsemblGenome=AGAP005913|UniProtKB=Q7Q6D2	AGAP005913-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF31	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00046	Oxidative stress response	P01129	JNK1/2	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01171	PLCgamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MACMU|Ensembl=ENSMMUG00000017374|UniProtKB=F7H6T7	Uncharacterized protein	ISS	10051575	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00709	Glycogen synthase D	PANTR|Ensembl=ENSPTRG00000011269|UniProtKB=H2R1A4	Uncharacterized protein	ISS	4212312	PubMed	PTHR10176:SF2	GLYCOGEN  STARCH  SYNTHASE, MUSCLE
P00029	Huntington disease	P00811	Arp2/3 complex	DANRE|ZFIN=ZDB-GENE-040116-1|UniProtKB=Q7ZUQ0	Actin related protein 2/3 complex, subunit 1A	ISS	12963527	gi	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00034	Integrin signalling pathway	P00925	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IDA	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00048	PI3 kinase pathway	P01177	P110ACT	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00053	T cell activation	P01336	Jnk	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01431	LRP5/6	BOVIN|Ensembl=ENSBTAG00000005903|UniProtKB=F1N1K8	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P02721	ATP synthesis	P02798	Cyt C	MACMU|Ensembl=ENSMMUG00000030295|UniProtKB=P00002	Cytochrome c	ISS	4954366	PubMed	PTHR11961:SF15	CYTOCHROME C
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Ensembl=ENSGALG00000003157|UniProtKB=E1C523	Uncharacterized protein	IEP	10938134	PubMed	PTHR13140:SF358	MYOSIN-7B
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TRIAD|EnsemblGenome=TriadG49626|UniProtKB=B3RKR4	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00005	Angiogenesis	P00187	beta catenin	DROME|FlyBase=FBgn0000117|UniProtKB=P18824	Armadillo segment polarity protein	ISS			PTHR23315:SF233	ARMADILLO SEGMENT POLARITY PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	CHICK|Ensembl=ENSGALG00000011558|UniProtKB=F1NWV6	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	MACMU|Ensembl=ENSMMUG00000002489|UniProtKB=F6ZTZ9	Uncharacterized protein	ISS			PTHR43521:SF1	ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE
P00053	T cell activation	P01306	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00056	VEGF signaling pathway	P01411	Ras	CHICK|Ensembl=ENSGALG00000014033|UniProtKB=E1BTS2	Uncharacterized protein	ISS	9869449	PubMed	PTHR24070:SF186	GTPASE KRAS
P00029	Huntington disease	P00796	Kainate receptor	BOVIN|Ensembl=ENSBTAG00000011723|UniProtKB=E1BKL6	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00049	Parkinson disease	P01219	SAPK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02759	Pyridoxal-5-phosphate biosynthesis	P03062	1-Deoxyxylulose-5-phosphate synthase	PLAF7|EnsemblGenome=MAL13P1.186|UniProtKB=Q8IDW0	1-deoxy-D-xylulose 5-phosphate synthase	ISS			PTHR43322:SF5	1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE 1-RELATED
P04393	Ras Pathway	P04570	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05755	Gbeta	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00019	Endothelin signaling pathway	P00590	IP3 R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	1171954	gi	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P04393	Ras Pathway	P04541	p90RSK	RAT|RGD=1563860|UniProtKB=D3Z8E0	Ribosomal protein S6 kinase	ISS	10480933	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00010	B cell activation	P00371	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00049	Parkinson disease	P01219	SAPK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04392	P53 pathway feedback loops 1	P04537	p73DeltaN	HUMAN|HGNC=15979|UniProtKB=Q9H3D4	Tumor protein 63	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	ARATH|TAIR=AT5G26780|UniProtKB=Q94C74	Serine hydroxymethyltransferase 2, mitochondrial	ISS			PTHR11680:SF12	SERINE HYDROXYMETHYLTRANSFERASE 2, MITOCHONDRIAL
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P06587	Nicotine pharmacodynamics pathway	P06596	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00221	JNK1	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00813	SH3GL3	BOVIN|Ensembl=ENSBTAG00000018004|UniProtKB=F1MX23	Uncharacterized protein	ISS	12932731	PubMed	PTHR43965:SF4	ENDOPHILIN-A3
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=1310389|UniProtKB=D3ZTF6	Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Predicted), isoform CRA_a	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	CHICK|Gene=PSEN2|UniProtKB=Q90X07	Presenilin-2	TAS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MACMU|Ensembl=ENSMMUG00000022808|UniProtKB=F6UWC3	Actin-related protein 2/3 complex subunit 2	ISS	17943202	gi	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00055	Transcription regulation by bZIP transcription factor	P01395	TFIIE	ANOGA|EnsemblGenome=AGAP005382|UniProtKB=Q7Q7C7	Transcription initiation factor IIE subunit beta	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	TAS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	DANRE|ZFIN=ZDB-GENE-030407-2|UniProtKB=F8W5D0	Uncharacterized protein (Fragment)	ISS			PTHR11681:SF13	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00539	14-3-3	BOVIN|Ensembl=ENSBTAG00000000236|UniProtKB=P63103	14-3-3 protein zeta/delta	ISS	12615066	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00021	FGF signaling pathway	P00632	Akt	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	IGI	12086862	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01445	Cerebus	PANTR|Ensembl=ENSPTRG00000020781|UniProtKB=H2QX07	Uncharacterized protein	ISS	10067895	PubMed	PTHR15273:SF4	CERBERUS
P00018	EGF receptor signaling pathway	P00565	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00010	B cell activation	P00385	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00023	General transcription regulation	P00659	TFIIEbeta	CANLF|Ensembl=ENSCAFG00000006489|UniProtKB=E2R5J2	Transcription initiation factor IIE subunit beta	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P05918	p38 MAPK pathway	P05921	MKP5	HUMAN|HGNC=3065|UniProtKB=Q9Y6W6	Dual specificity protein phosphatase 10	RCA	10597297	PubMed	PTHR10159:SF299	DUAL SPECIFICITY PROTEIN PHOSPHATASE 10
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	XENTR|Xenbase=XB-GENE-487069|UniProtKB=F6RN85	Uncharacterized protein	ISS	10806215	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00057	Wnt signaling pathway	P01433	SIAH-1	ARATH|TAIR=AT3G58040|UniProtKB=Q9M2P4	E3 ubiquitin-protein ligase SINAT2	ISS	11389839	PubMed	PTHR10315:SF70	E3 UBIQUITIN-PROTEIN LIGASE SINA-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	ARATH|TAIR=AT2G32400|UniProtKB=Q9SDQ4	Glutamate receptor 3.7	ISS	12941441	PubMed	PTHR43891:SF15	GLUTAMATE RECEPTOR 3.7
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	HUMAN|HGNC=4599|UniProtKB=Q14831	Metabotropic glutamate receptor 7	ISS	11431030	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00018	EGF receptor signaling pathway	P00557	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IGI	7565716	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00964	p90RSK	BOVIN|Ensembl=ENSBTAG00000002015|UniProtKB=G5E5T2	Uncharacterized protein	ISS	15632195	PubMed	PTHR24351:SF98	RIBOSOMAL PROTEIN S6 KINASE ALPHA-6
P00047	PDGF signaling pathway	P01153	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=12785|UniProtKB=Q9Y6F9	Protein Wnt-6	IDA	11266476	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P00029	Huntington disease	G01529	Proline oxidase	YEAST|SGD=S000004132|UniProtKB=P09368	Proline dehydrogenase, mitochondrial	NAS			PTHR13914:SF0	PROLINE DEHYDROGENASE 1, MITOCHONDRIAL
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IDA	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04398	p53 pathway feedback loops 2	P04651	Ras	DAPPU|EnsemblGenome=DAPPUDRAFT_301818|UniProtKB=E9I1I7	Putative uncharacterized protein	ISS	20148920	PubMed	PTHR24070:SF385	GTPASE HRAS
P00025	Hedgehog signaling pathway	P00691	CBP	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05731	GABA-B receptor II signaling	P05760	AC	PANTR|Ensembl=ENSPTRG00000019161|UniProtKB=H2QUJ4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P00010	B cell activation	P00371	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	PANTR|Gene=DVL1|UniProtKB=Q5IS48	Segment polarity protein dishevelled homolog DVL-1	ISS	12549854	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P00052	TGF-beta signaling pathway	P01275	P38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00243	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P02740	De novo pyrimidine ribonucleotides biosythesis	P02927	Dihydrooratate oxidase	YEAST|SGD=S000001699|UniProtKB=P28272	Dihydroorotate dehydrogenase (fumarate)	ISS			PTHR43843:SF1	DIHYDROOROTATE DEHYDROGENASE  FUMARATE
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00047	PDGF signaling pathway	P01162	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	HUMAN|HGNC=10945|UniProtKB=O00341	Excitatory amino acid transporter 5	IC	94365697	PubMed	PTHR11958:SF22	EXCITATORY AMINO ACID TRANSPORTER 5
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	RAT|RGD=3425|UniProtKB=P97887	Presenilin-1	TAS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00036	Interleukin signaling pathway	P00976	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00034	Integrin signalling pathway	P00906	Rap1	DANRE|Ensembl=ENSDARG00000077553|UniProtKB=E7F144	Uncharacterized protein	ISS	8576107	PubMed	PTHR24070:SF221	RAS-RELATED PROTEIN RAP-2A
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00254	GTPase	RAT|RGD=1304965|UniProtKB=A0A0G2K6E0	Protein Rhoc	ISS	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P05731	GABA-B receptor II signaling	P05754	Ggamma	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00046	Oxidative stress response	P01135	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00023	General transcription regulation	P00658	TBP-associated factors	CAEEL|WormBase=WBGene00006390|UniProtKB=Q7YTH5	TAF (TBP-associated transcription factor) family	ISS	604904	OMIM	PTHR12321:SF78	TAF  TBP-ASSOCIATED TRANSCRIPTION FACTOR  FAMILY
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	CANLF|Gene=GRIN1|UniProtKB=Q5R1P0	Glutamate receptor ionotropic, NMDA 1	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00021	FGF signaling pathway	P00633	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00058	mRNA splicing	P01476	U4	HUMAN|HGNC=17348|UniProtKB=O43395	U4/U6 small nuclear ribonucleoprotein Prp3	IDA	12875835	PubMed	PTHR14212:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	IC	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	BRAFL|Gene=BRAFLDRAFT_60743|UniProtKB=C3XYD4	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	RAT|RGD=1311443|UniProtKB=D3Z8L7	Ras-related protein R-Ras	ISS	7997267	PubMed	PTHR24070:SF245	RAS-RELATED PROTEIN R-RAS
P04398	p53 pathway feedback loops 2	G04714	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00059	p53 pathway	P01485	p53	RAT|RGD=1307083|UniProtKB=D4AA88	Protein Tp73	ISS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	CHICK|Gene=PSEN2|UniProtKB=Q90X07	Presenilin-2	IDA	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00020	FAS signaling pathway	P00608	Pro-Caspase3	TAKRU|Ensembl=ENSTRUG00000015915|UniProtKB=H2UUR6	Uncharacterized protein (Fragment)	IGI	9323209	PubMed	PTHR10454:SF198	CASPASE-3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	IDA	10995439	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05917	Opioid proopiomelanocortin pathway	P06011	AC	RAT|RGD=619965|UniProtKB=P26769	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00019	Endothelin signaling pathway	P00582	COX-2	MACMU|Ensembl=ENSMMUG00000016857|UniProtKB=F7BWZ9	Uncharacterized protein	ISS	9528947	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P00054	Toll receptor signaling pathway	P01358	ERK1	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00005	Angiogenesis	P00185	JAK1	MOUSE|MGI=MGI=96628|UniProtKB=P52332	Tyrosine-protein kinase JAK1	ISS	9637709	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00056	VEGF signaling pathway	P01411	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	MACMU|Ensembl=ENSMMUG00000013637|UniProtKB=F7GL52	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-040426-1693|UniProtKB=Q6P967	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	TAS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00029	Huntington disease	P00799	JNK-2	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=1310389|UniProtKB=D3ZTF6	Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Predicted), isoform CRA_a	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	DANRE|ZFIN=ZDB-GENE-051202-2|UniProtKB=Q6ZM67	Uncharacterized protein	ISS	92049750	PubMed	PTHR44391:SF3	SUBFAMILY NOT NAMED
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	HUMAN|HGNC=4573|UniProtKB=P42263	Glutamate receptor 3	IC	12941441	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P05916	Opioid prodynorphin pathway	P06002	G-protein	MONDO|Ensembl=ENSMODG00000005623|UniProtKB=F7CFG8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04398	p53 pathway feedback loops 2	P04658	PTEN	MACMU|Ensembl=ENSMMUG00000008431|UniProtKB=F6VBA7	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	IC	176892	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=108061|UniProtKB=P48614	Protein Wnt-10b	TAS	12549854	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00034	Integrin signalling pathway	P00924	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01084	CHT1	MOUSE|MGI=MGI=2147834|UniProtKB=Q8VBW1	Sodium- and chloride-dependent creatine transporter 1	ISS			PTHR11616:SF96	SODIUM- AND CHLORIDE-DEPENDENT CREATINE TRANSPORTER 1
P00053	T cell activation	P01294	NFAT	MACMU|Ensembl=ENSMMUG00000012657|UniProtKB=F7E7J1	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-040718-93|UniProtKB=Q6DGZ5	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00049	Parkinson disease	P01219	SAPK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05918	p38 MAPK pathway	P06021	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF248	SUBFAMILY NOT NAMED
P04377	Beta1 adrenergic receptor signaling pathway	P04433	Beta1	PANTR|Ensembl=ENSPTRG00000002956|UniProtKB=H2Q2L5	Uncharacterized protein	ISS	12730078	PubMed	PTHR24248:SF54	BETA-1 ADRENERGIC RECEPTOR
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00029	Huntington disease	P00766	Htt	CANLF|Ensembl=ENSCAFG00000014682|UniProtKB=F1P7Y7	Uncharacterized protein	ISS	7620118	PubMed	PTHR10170:SF10	HUNTINGTIN
P00018	EGF receptor signaling pathway	P00551	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	RCA	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	ANOGA|EnsemblGenome=AGAP010172|UniProtKB=Q7PD38	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	METAC|EnsemblGenome=MA_2860|UniProtKB=Q8TM10	Aldehyde dehydrogenase (NAD+)	IC			PTHR43521:SF2	DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 12A1, MITOCHONDRIAL
P00021	FGF signaling pathway	P00632	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00577	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00474	Wnt	CHICK|Ensembl=ENSGALG00000000839|UniProtKB=P49339	Protein Wnt-11	IDA	8717036	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P05730	Endogenous cannabinoid signaling	P05751	Galpha	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	RCA	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00559	MEK1-2	ARATH|TAIR=AT4G29810|UniProtKB=Q9S7U9	Mitogen-activated protein kinase kinase 2	ISS			PTHR24361:SF395	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5
P00045	Notch signaling pathway	P01104	Serrate	MOUSE|MGI=MGI=1095416|UniProtKB=Q9QXX0	Protein jagged-1	IPI	8955070	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00012	Cadherin signaling pathway	P00477	GSK3beta	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04393	Ras Pathway	P04553	PAK	BOVIN|Ensembl=ENSBTAG00000047856|UniProtKB=G3MZE2	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00059	p53 pathway	G04702	p53	BOVIN|Ensembl=ENSBTAG00000015460|UniProtKB=F1MKA9	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P04393	Ras Pathway	P04548	ATF2	RAT|RGD=621862|UniProtKB=Q00969	Cyclic AMP-dependent transcription factor ATF-2	ISS	7875593	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00021	FGF signaling pathway	P00633	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P02743	Formyltetrahydroformate biosynthesis	P02952	Methylene tetrahydrofolate dehydrogenase	HALSA|EnsemblGenome=VNG_1416G|UniProtKB=Q9HPY4	Bifunctional protein FolD	ISS			PTHR10025:SF46	BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, MITOCHONDRIAL
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	CHICK|Ensembl=ENSGALG00000009320|UniProtKB=Q4JIM4	Presenilin-1	TAS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P06587	Nicotine pharmacodynamics pathway	P06604	SLC18A2	BOVIN|Gene=SLC18A2|UniProtKB=Q27963	Synaptic vesicular amine transporter	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00010	B cell activation	P00381	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00010	B cell activation	P00383	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00057	Wnt signaling pathway	P01468	APC	MACMU|Ensembl=ENSMMUG00000003053|UniProtKB=F6VET0	Uncharacterized protein	ISS	10491393	PubMed	PTHR12607:SF3	ADENOMATOUS POLYPOSIS COLI PROTEIN 2
P02775	Salvage pyrimidine ribonucleotides	P03156	CDP kinase	ARATH|TAIR=AT1G73980|UniProtKB=Q9C9B9	At1g73980/F2P9_15	ISS			PTHR10285:SF122	URIDINE-CYTIDINE KINASE C
P05913	Enkephalin release	P05978	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00006	Apoptosis signaling pathway	P00260	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05731	GABA-B receptor II signaling	P05754	Ggamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00013	Cell cycle	P00480	Proteasome	CANLF|Ensembl=ENSCAFG00000012565|UniProtKB=F1PRW0	Uncharacterized protein	ISS	10505793	PubMed	PTHR10223:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4
P00005	Angiogenesis	P00252	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	10521483	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	BOVIN|Ensembl=ENSBTAG00000014299|UniProtKB=Q1RMJ6	Rho-related GTP-binding protein RhoC	ISS	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00012	Cadherin signaling pathway	P00474	Wnt	BOVIN|Ensembl=ENSBTAG00000010820|UniProtKB=F1N4C0	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04619	HMG1	HUMAN|HGNC=4983|UniProtKB=P09429	High mobility group protein B1	ISS			PTHR13711:SF164	HIGH MOBILITY GROUP PROTEIN B1-RELATED
P00012	Cadherin signaling pathway	P00466	EGFR	MACMU|Gene=EGFR|UniProtKB=P55245	Epidermal growth factor receptor	ISS	90258888	PubMed	PTHR24416:SF91	EPIDERMAL GROWTH FACTOR RECEPTOR
P02771	Pyrimidine Metabolism	P03124	Methylmalonate Semialdehyde Dehydrogenase	BOVIN|Gene=ALDH6A1|UniProtKB=Q07536	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	ISS	1527093	PubMed	PTHR43866:SF3	METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE  ACYLATING , MITOCHONDRIAL
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000006307|UniProtKB=H2SSM1	Uncharacterized protein	ISS			PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00057	Wnt signaling pathway	P01468	APC	DROME|FlyBase=FBgn0026598|UniProtKB=Q9Y1T2	Adenomatous polyposis coli 2	ISS	8259518	PubMed	PTHR12607:SF12	APC-LIKE, ISOFORM A-RELATED
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	BOVIN|Ensembl=ENSBTAG00000012927|UniProtKB=A6QLL8	Fructose-bisphosphate aldolase	ISS	4812352	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00046	Oxidative stress response	P01134	cPLA2	CHICK|Ensembl=ENSGALG00000005065|UniProtKB=P49147	Cytosolic phospholipase A2	TAS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANAL|CGD=CAL0068551|UniProtKB=Q5AAR9	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	TAS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00012	Cadherin signaling pathway	P00475	Frizzled	BOVIN|Ensembl=ENSBTAG00000007047|UniProtKB=A3KMX5	FZD10 protein	ISS	8717036	PubMed	PTHR11309:SF86	FRIZZLED-10
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	12846562	PubMed	PTHR10202:SF13	PRESENILIN-2
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	STRCO|EnsemblGenome=CAB75393|UniProtKB=P50589	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05916	Opioid prodynorphin pathway	P06002	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DROME|FlyBase=FBgn0011743|UniProtKB=P45891	Actin-like protein 53D	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	ARATH|TAIR=AT1G54140|UniProtKB=Q9SYH2	Transcription initiation factor TFIID subunit 9	ISS			PTHR12595:SF6	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 9
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00029	Huntington disease	P00774	Dynein complex	ORNAN|Ensembl=ENSOANG00000008576|UniProtKB=F6PI02	Uncharacterized protein	ISS	9454836	PubMed	PTHR12442:SF22	CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00878	INFgamma	MACMU|Ensembl=ENSMMUG00000019225|UniProtKB=P63310	Interferon gamma	TAS	11175845	PubMed	PTHR11419:SF0	INTERFERON GAMMA
P00049	Parkinson disease	P01208	Hsp70	CAEBR|Gene=CBG00457|UniProtKB=A8WN50	Protein CBR-HSP-1	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P04393	Ras Pathway	P04557	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8440264	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00049	Parkinson disease	P01211	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00019	Endothelin signaling pathway	P00570	PKA	DICDI|dictyBase=DDB_G0279413|UniProtKB=P05987	cAMP-dependent protein kinase regulatory subunit	IGI	91298951	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00627	ERK1-2	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00012	Cadherin signaling pathway	P00477	GSK3beta	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00056	VEGF signaling pathway	P01409	cPLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	SCHPO|PomBase=SPAC806.07|UniProtKB=P49740	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P02746	Heme biosynthesis	P02973	Uroporphyrinogen methyltransferase	DEIRA|EnsemblGenome=DR_A0011|UniProtKB=Q9RZD8	Uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase	ISS			PTHR21091:SF16	SIROHEME SYNTHASE
P05915	Opioid proenkephalin pathway	P05991	Enkephalin	MACMU|Ensembl=ENSMMUG00000009984|UniProtKB=F6R267	Beta-neoendorphin-dynorphin	ISS	131330	OMIM	PTHR11438:SF4	PROENKEPHALIN-B
P00056	VEGF signaling pathway	P01414	PLC-gamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	RCA	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	RCA	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05915	Opioid proenkephalin pathway	P05994	G-protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00566	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	11204774	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01089	VAChT	PANTR|Ensembl=ENSPTRG00000002490|UniProtKB=H2Q1W2	Uncharacterized protein	ISS	7938002	PubMed	PTHR23506:SF13	VESICULAR ACETYLCHOLINE TRANSPORTER
P04395	Vasopressin synthesis	P04589	Signal Peptidase	ARATH|TAIR=AT4G04200|UniProtKB=F4JGB4	Signal peptidase subunit-25	IC	2092035	PubMed	PTHR13085:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04393	Ras Pathway	P04559	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	IDA	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00021	FGF signaling pathway	P00642	MEK1-2	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00034	Integrin signalling pathway	P00920	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04398	p53 pathway feedback loops 2	P04651	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04393	Ras Pathway	P04557	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00053	T cell activation	P01322	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01158	PDGF receptor A	MOUSE|MGI=MGI=1916047|UniProtKB=Q6PE55	Platelet-derived growth factor receptor-like protein	ISS			PTHR15360:SF1	PLATELET-DERIVED GROWTH FACTOR RECEPTOR-LIKE PROTEIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00053	T cell activation	P01323	I kappa B	MOUSE|MGI=MGI=104741|UniProtKB=Q9Z1E3	NF-kappa-B inhibitor alpha	ISS	99081292	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	TAS	11554554	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00005	Angiogenesis	P00206	Wnt	TAKRU|Ensembl=ENSTRUG00000011280|UniProtKB=H2TUW3	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00034	Integrin signalling pathway	P00907	ERK	PANTR|Ensembl=ENSPTRG00000020224|UniProtKB=H2Q9G3	Mitogen-activated protein kinase 6	ISS	8444355	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00005	Angiogenesis	P00189	Fzd	DANRE|ZFIN=ZDB-GENE-990415-218|UniProtKB=B3DIG4	Frizzled homolog 8c	ISS	8717036	PubMed	PTHR11309:SF126	FRIZZLED-5
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	IC	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00269	MAPK	ORYSJ|EnsemblGenome=OS06G0154500|UniProtKB=Q84UI5	Mitogen-activated protein kinase 1	ISS	10589842	PubMed	PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P05913	Enkephalin release	P05972	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	MOUSE|MGI=MGI=1861722|UniProtKB=Q9JHW9	Aldehyde dehydrogenase family 1 member A3	IC			PTHR11699:SF209	ALDEHYDE DEHYDROGENASE FAMILY 1 MEMBER A3
P02729	Ascorbate degradation	P02852	L-xylulose-5-phosphate-3-epimerase	CANLF|Ensembl=ENSCAFG00000013811|UniProtKB=F6V404	Ribulose-phosphate 3-epimerase	ISS			PTHR11749:SF3	RIBULOSE-PHOSPHATE 3-EPIMERASE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	YEAST|SGD=S000006189|UniProtKB=P32383	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00029	Huntington disease	P00797	p53	MOUSE|MGI=MGI=1330810|UniProtKB=O88898	Tumor protein 63	TAS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00029	Huntington disease	P00786	ARF	DROME|FlyBase=FBgn0013749|UniProtKB=P40945	ADP-ribosylation factor 2	IPI	12932731	PubMed	PTHR11711:SF308	ADP-RIBOSYLATION FACTOR 5
P00036	Interleukin signaling pathway	P00996	STAT	BOVIN|Gene=STAT3|UniProtKB=P61635	Signal transducer and activator of transcription 3	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	11591316	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04393	Ras Pathway	P04572	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IDA	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00053	T cell activation	P01312	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	CHICK|Ensembl=ENSGALG00000002003|UniProtKB=F1P3H0	Receptor protein serine/threonine kinase	TAS	9395284	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P00011	Blood coagulation	P00455	GP IX	RAT|RGD=1561601|UniProtKB=Q4AEG0	Glycoprotein 9	ISS	98353120	PubMed	PTHR22650:SF6	PLATELET GLYCOPROTEIN IX
P04393	Ras Pathway	P04556	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IDA	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01332	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	IDA	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00269	MAPK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	20384797	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	IC	9199552	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00011	Blood coagulation	P00454	FVII	PANTR|Gene=F7|UniProtKB=Q2F9P2	Coagulation factor VII	ISS	11487022	PubMed	PTHR44064:SF1	COAGULATION FACTOR VII
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00010	B cell activation	P00381	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02733	Carnitine metabolism	P02866	Carnitine dehydratase	PSEAE|EnsemblGenome=PA0446|UniProtKB=Q9I672	Uncharacterized protein	ISS			PTHR43949:SF6	SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00786	ARF	MACMU|Ensembl=ENSMMUG00000021421|UniProtKB=F7EF01	Uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF234	ADP-RIBOSYLATION FACTOR 1
P00056	VEGF signaling pathway	P01417	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04564	MAPKAP	PANTR|Ensembl=ENSPTRG00000001915|UniProtKB=H2Q104	Mitogen-activated protein kinase-activated protein kinase 2	ISS	9628873	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MOUSE|MGI=MGI=1930780|UniProtKB=Q61879	Myosin-10	ISS	89264452	PubMed	PTHR13140:SF328	MYOSIN-10
P00011	Blood coagulation	P00450	Tissue Factor	PANTR|Ensembl=ENSPTRG00000000977|UniProtKB=H2R022	Tissue factor	ISS	8779717	PubMed	PTHR20859:SF22	TISSUE FACTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	MONDO|Ensembl=ENSMODG00000023104|UniProtKB=F7AZP2	Uncharacterized protein	ISS	22247722	PubMed	PTHR44282:SF3	SUPPRESSOR OF CYTOKINE SIGNALING 5
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_188187|UniProtKB=E9GJ31	Guanine nucleotide binding protein, q polypeptide	ISS	8836152	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00057	Wnt signaling pathway	P01435	SWI/SNF	BOVIN|Ensembl=ENSBTAG00000002728|UniProtKB=F1MKU0	Uncharacterized protein	ISS	11532957	PubMed	PTHR12656:SF11	AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 1B
P00054	Toll receptor signaling pathway	P01354	NFkappaB	MOUSE|MGI=MGI=1099800|UniProtKB=Q9WTK5	Nuclear factor NF-kappa-B p100 subunit	ISS	20151924	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00015	Circadian clock system	P00506	BMAL1	TAKRU|Ensembl=ENSTRUG00000008391|UniProtKB=H2T8M1	Uncharacterized protein	ISS			PTHR23042:SF52	ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00044	Nicotinic acetylcholine receptor signaling pathway	P01092	delta	HUMAN|HGNC=1965|UniProtKB=Q07001	Acetylcholine receptor subunit delta	ISS	85203892	PubMed	PTHR18945:SF61	ACETYLCHOLINE RECEPTOR SUBUNIT DELTA
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IPI	7937853	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00056	VEGF signaling pathway	P01412	HSP27	BOVIN|Ensembl=ENSBTAG00000003134|UniProtKB=P02470	Alpha-crystallin A chain	ISS			PTHR11527:SF36	ALPHA-CRYSTALLIN A CHAIN
P00040	Metabotropic glutamate receptor group II pathway	G01540	BDNF	MOUSE|MGI=MGI=88145|UniProtKB=P21237	Brain-derived neurotrophic factor	ISS	11724916	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00034	Integrin signalling pathway	P00925	MEK	MONDO|Ensembl=ENSMODG00000001404|UniProtKB=F7BD74	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=5292|UniProtKB=P30939	5-hydroxytryptamine receptor 1F	IDA	11701344	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00005	Angiogenesis	P00256	PLC-gamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04393	Ras Pathway	P04563	Ets	ORNAN|Ensembl=ENSOANG00000012104|UniProtKB=F7FH70	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00025	Hedgehog signaling pathway	P00682	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00705	Gsalpha	CHICK|Ensembl=ENSGALG00000007509|UniProtKB=F1NM72	Uncharacterized protein	ISS	87005246	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00029	Huntington disease	P00801	Fos protein	PANTR|Ensembl=ENSPTRG00000006553|UniProtKB=A5A6H0	C-fos	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04393	Ras Pathway	P04547	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00059	p53 pathway	G04689	Cyclin G	MONDO|Ensembl=ENSMODG00000007651|UniProtKB=F7FZG0	Uncharacterized protein	ISS	7957050	PubMed	PTHR10177:SF59	CYCLIN-G1
P00049	Parkinson disease	P01242	Casein kinase I	MACMU|Ensembl=ENSMMUG00000001758|UniProtKB=F6TN15	Uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF84	CASEIN KINASE I ISOFORM ALPHA
P00006	Apoptosis signaling pathway	P00269	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	ORNAN|Ensembl=ENSOANG00000013097|UniProtKB=F6UVN1	Uncharacterized protein	ISS	10082669	PubMed	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00047	PDGF signaling pathway	P01143	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	97449291	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00029	Huntington disease	P00790	beta-Tubulin	STRPU|EnsemblGenome=SPU_007425|UniProtKB=W4XVG9	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00059	p53 pathway	G04700	PAI	MACMU|Ensembl=ENSMMUG00000009926|UniProtKB=F6Y5D7	Uncharacterized protein	ISS	189578	gi	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00053	T cell activation	P01300	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00036	Interleukin signaling pathway	P00981	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	DANRE|ZFIN=ZDB-GENE-000502-1|UniProtKB=Q1RLX1	Receptor protein serine/threonine kinase	TAS	9395284	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P00036	Interleukin signaling pathway	P00990	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00047	PDGF signaling pathway	P01153	GSK3	YEAST|SGD=S000004747|UniProtKB=P38615	Serine/threonine-protein kinase RIM11/MSD1	ISS	21361340	gi	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P05918	p38 MAPK pathway	P06036	MKK3	PANTR|Ensembl=ENSPTRG00000008895|UniProtKB=H2R497	Mitogen-activated protein kinase kinase 3	ISS	11279172	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00035	Interferon-gamma signaling pathway	P00956	SOCS	MOUSE|MGI=MGI=1201791|UniProtKB=O35718	Suppressor of cytokine signaling 3	ISS	15032587	PubMed	PTHR44534:SF3	SUPPRESSOR OF CYTOKINE SIGNALING 3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MOUSE|MGI=MGI=1278318|UniProtKB=O88537	Formyl peptide receptor-related sequence 3	IC			PTHR24225:SF18	FORMYL PEPTIDE RECEPTOR-RELATED SEQUENCE 3
P00056	VEGF signaling pathway	P01423	p38MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IDA	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00034	Integrin signalling pathway	P00941	Integrin alpha	PANTR|Ensembl=ENSPTRG00000009277|UniProtKB=H2QD72	Uncharacterized protein	ISS	3487386	PubMed	PTHR23220:SF73	INTEGRIN ALPHA-IIB
P00025	Hedgehog signaling pathway	P00682	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00475	Frizzled	HUMAN|HGNC=4042|UniProtKB=Q9ULV1	Frizzled-4	IDA	8717036	PubMed	PTHR11309:SF23	FRIZZLED-4
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	RAT|RGD=727925|UniProtKB=Q7TT51	Lengsin	ISS			PTHR43407:SF1	LENGSIN
P00057	Wnt signaling pathway	P01471	alpha-catenin	RAT|RGD=1359485|UniProtKB=Q5U302	Catenin (Cadherin associated protein), alpha 1	ISS	10456847	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P02772	Pyruvate metabolism	P03135	Phosphoenolpyruvate Carboxykinase	MOUSE|MGI=MGI=97501|UniProtKB=Q9Z2V4	Phosphoenolpyruvate carboxykinase, cytosolic [GTP]	ISS	8325643	PubMed	PTHR11561:SF1	PHOSPHOENOLPYRUVATE CARBOXYKINASE, CYTOSOLIC  GTP
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	10799299	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CHICK|GeneID=396338|UniProtKB=P51050	Melatonin receptor type 1B (Fragment)	IDA			PTHR43962:SF6	MELATONIN RECEPTOR TYPE 1B
P02746	Heme biosynthesis	P02975	Uroporphyrinogen decarboxylase	CANLF|Ensembl=ENSCAFG00000004646|UniProtKB=E2RCH3	Uroporphyrinogen decarboxylase	ISS			PTHR21091:SF2	UROPORPHYRINOGEN DECARBOXYLASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00634	MEKK1-5	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS	97236778	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00057	Wnt signaling pathway	P01457	GBeta	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00034	Integrin signalling pathway	P00925	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00059	p53 pathway	P04624	Cdc25C	HUMAN|HGNC=1727|UniProtKB=P30307	M-phase inducer phosphatase 3	IDA	9520381	PubMed	PTHR10828:SF64	M-PHASE INDUCER PHOSPHATASE 3
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	RAT|RGD=620467|UniProtKB=Q9JHU0	Dihydropyrimidinase-related protein 5	IPI	11034345	PubMed	PTHR11647:SF58	DIHYDROPYRIMIDINASE-RELATED PROTEIN 5
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	MOUSE|MGI=MGI=95818|UniProtKB=Q61626	Glutamate receptor ionotropic, kainate 5	ISS	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04380	Cortocotropin releasing factor receptor signaling pathway	P04453	ACTH	XENTR|Xenbase=XB-GENE-483703|UniProtKB=Q5M8F2	Proopiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	SCHPO|PomBase=SPBC32H8.07|UniProtKB=Q10282	Guanine nucleotide-binding protein subunit beta	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	HUMAN|HGNC=669|UniProtKB=P08134	Rho-related GTP-binding protein RhoC	ISS	12090470	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	TAS	10799299	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02920	dCTP deaminase	DEIRA|EnsemblGenome=DR_1207|UniProtKB=Q9RV23	tRNA(Ile)-lysidine synthase	ISS			PTHR43033:SF1	TRNA ILE -LYSIDINE SYNTHASE
P00019	Endothelin signaling pathway	P00586	Gq	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00020	FAS signaling pathway	P00609	FAF1	MOUSE|MGI=MGI=109419|UniProtKB=P54731	FAS-associated factor 1	IGI	8524870	PubMed	PTHR23322:SF52	FAS-ASSOCIATED FACTOR 1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	CAEBR|Gene=CBG02247|UniProtKB=A8WS68	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00057	Wnt signaling pathway	P01451	Galpha	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00321	HSP70	YEAST|SGD=S000000171|UniProtKB=P09435	Heat shock protein SSA3	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	HUMAN|HGNC=1954|UniProtKB=P08912	Muscarinic acetylcholine receptor M5	IDA	11166329	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IDA	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	RAT|RGD=620873|UniProtKB=Q91Z84	Interleukin-23 subunit alpha	IC			PTHR15947:SF0	INTERLEUKIN-23 SUBUNIT ALPHA
P05913	Enkephalin release	P05974	G-Protein (i)	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	PANTR|Ensembl=ENSPTRG00000012658|UniProtKB=H2QJ05	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF74	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	NEUCR|EnsemblGenome=EFNCRG00000005070|UniProtKB=Q7S8Z5	DNA-directed RNA polymerase II polypeptide	ISS	11313498	PubMed	PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000002339|UniProtKB=H2R368	Uncharacterized protein	ISS	20088160	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00004	Alzheimer disease-presenilin pathway	P00118	E-cadherin	PANTR|Ensembl=ENSPTRG00000008269|UniProtKB=H2QBE4	Cadherin 3, type 1, P-cadherin (Placental)	ISS	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P00021	FGF signaling pathway	P00636	FGFR1-4	PANTR|Ensembl=ENSPTRG00000015836|UniProtKB=H2QP39	Fibroblast growth factor receptor	ISS	12441294	PubMed	PTHR24416:SF505	FIBROBLAST GROWTH FACTOR RECEPTOR 3
P00019	Endothelin signaling pathway	P00566	ERK	ARATH|TAIR=AT1G59580|UniProtKB=Q39022	Mitogen-activated protein kinase 2	IGI			PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00034	Integrin signalling pathway	P00925	MEK	CHICK|Ensembl=ENSGALG00000004735|UniProtKB=F1NHE1	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04395	Vasopressin synthesis	P04590	Vasopressin	TAKRU|Ensembl=ENSTRUG00000015413|UniProtKB=H2UR30	Uncharacterized protein	ISS			PTHR11681:SF13	SUBFAMILY NOT NAMED
P00017	DNA replication	P00536	DNA Topisomerase	CHICK|Ensembl=ENSGALG00000003681|UniProtKB=R4GM79	Uncharacterized protein	ISS			PTHR10290:SF5	DNA TOPOISOMERASE 1
P00036	Interleukin signaling pathway	P00973	PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	MOUSE|MGI=MGI=109482|UniProtKB=P97445	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	11976940	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04395	Vasopressin synthesis	P04593	Glycopeptide	MOUSE|MGI=MGI=97453|UniProtKB=P35454	Oxytocin-neurophysin 1	IC	9756087	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	IC	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Ensembl=ENSPTRG00000013825|UniProtKB=H2RAK4	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00020	FAS signaling pathway	P00615	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00623	FGF	MACMU|Ensembl=ENSMMUG00000017689|UniProtKB=F6U9K3	Fibroblast growth factor	ISS	8790420	PubMed	PTHR11486:SF67	FIBROBLAST GROWTH FACTOR 11
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	BOVIN|Ensembl=ENSBTAG00000012516|UniProtKB=F1MUT8	Uncharacterized protein	ISS	94365697	PubMed	PTHR11958:SF22	EXCITATORY AMINO ACID TRANSPORTER 5
P00056	VEGF signaling pathway	P01409	cPLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00004	Alzheimer disease-presenilin pathway	P00127	APP	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	11292874	PubMed	PTHR10048:SF14	PI-3 KINASE
P00018	EGF receptor signaling pathway	P00555	MKK4,7	MONDO|Ensembl=ENSMODG00000008266|UniProtKB=F6Z879	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00036	Interleukin signaling pathway	P00986	eNOS	CANLF|Gene=NOS3|UniProtKB=Q9TUX8	Nitric oxide synthase, endothelial	ISS	9837777	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1718748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00001	Adrenaline and noradrenaline biosynthesis	P00063	DBH	BOVIN|Ensembl=ENSBTAG00000004508|UniProtKB=P15101	Dopamine beta-hydroxylase	ISS	90219125	PubMed	PTHR10157:SF29	DOPAMINE BETA-HYDROXYLASE
P00053	T cell activation	P01294	NFAT	PANTR|Ensembl=ENSPTRG00000013628|UniProtKB=H2R4F5	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00053	T cell activation	P01300	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00562	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00056	VEGF signaling pathway	P01414	PLC-gamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	LEIMA|EnsemblGenome=LmjF.18.1080|UniProtKB=Q27687	Protein kinase A catalytic subunit	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DROME|FlyBase=FBgn0259680|UniProtKB=P83099	Putative protein kinase C delta type homolog	ISS	3045562	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=108071|UniProtKB=P70701	Protein Wnt-10a	IDA	11266476	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Ensembl=ENSGALG00000009621|UniProtKB=P60706	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P02780	Thiamin metabolism	P03176	Thiamine kinase	YEAST|SGD=S000005669|UniProtKB=P35202	Thiamine pyrophosphokinase	IDA	8394343	PubMed	PTHR13622:SF8	THIAMIN PYROPHOSPHOKINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00877	MLCK	CHICK|Gene=Mylk|UniProtKB=P11799	Myosin light chain kinase, smooth muscle	IDA	600922	OMIM	PTHR45480:SF1	MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00010	B cell activation	P00391	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05756	GABA-B receptor	HUMAN|HGNC=4507|UniProtKB=O75899	Gamma-aminobutyric acid type B receptor subunit 2	IDA	9872315	PubMed	PTHR10519:SF62	GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2
P00018	EGF receptor signaling pathway	P00541	Spry	HUMAN|HGNC=15533|UniProtKB=Q9C004	Protein sprouty homolog 4	ISS	99264295	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DICPU|Gene=DICPUDRAFT_93216|UniProtKB=F1A421	Guanine nucleotide-binding protein subunit beta	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00057	Wnt signaling pathway	P01444	Wnt	MACMU|Ensembl=ENSMMUG00000020810|UniProtKB=F7H7P6	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF84	PROTEIN WNT-9B
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00005	Angiogenesis	P00188	Ets	HUMAN|HGNC=3488|UniProtKB=P14921	Protein C-ets-1	IDA	9157999	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00048	PI3 kinase pathway	P01192	p110	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00807	Actin	CAEEL|WormBase=WBGene00000067|UniProtKB=O45815	ACTin	IDA	3487386	PubMed	PTHR11937:SF352	ACTIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	IC	10514528	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00029	Huntington disease	P00797	p53	ANOGA|EnsemblGenome=AGAP004319|UniProtKB=Q7QAB9	AGAP004319-PA	TAS	12932731	PubMed	PTHR11447:SF16	P53 PROTEIN LONG FORM VARIANT 1
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CAEBR|Gene=CBG01555|UniProtKB=A8WRD7	Mitogen-activated protein kinase	ISS	11703092	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	RAT|RGD=2735|UniProtKB=Q63273	Glutamate receptor ionotropic, kainate 5	ISS	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000004896|UniProtKB=F7C2C6	Uncharacterized protein (Fragment)	ISS	8444355	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00053	T cell activation	P01330	IKK	BOVIN|Ensembl=ENSBTAG00000007599|UniProtKB=Q95KV0	Inhibitor of nuclear factor kappa-B kinase subunit beta	IGI	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00056	VEGF signaling pathway	P01417	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHICK|Gene=ACTA2|UniProtKB=P08023	Actin, aortic smooth muscle	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00036	Interleukin signaling pathway	P00990	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	IDA	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04393	Ras Pathway	P04547	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00038	JAK/STAT signaling pathway	P01029	Serine kinase	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS			PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IDA	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05915	Opioid proenkephalin pathway	P05994	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	RAT|RGD=619751|UniProtKB=O88302	Guanine nucleotide-binding protein subunit alpha-15	ISS	10629036	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00568	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	3755548	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	XENTR|Ensembl=ENSXETG00000021375|UniProtKB=F6T423	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	HUMAN|HGNC=7882|UniProtKB=Q04721	Neurogenic locus notch homolog protein 2	IDA	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	STRCO|EnsemblGenome=CAA19995|UniProtKB=O86528	Glutamate--tRNA ligase	ISS			PTHR43311:SF2	GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED
P00010	B cell activation	P00371	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01444	Wnt	XENTR|Ensembl=ENSXETG00000024231|UniProtKB=F6TCQ4	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P02728	Arginine biosynthesis	P02847	N-actetylornithine deacetylase	STRCO|Gene=CAC01315|UniProtKB=Q9FCK3	Putative peptidase	ISS			PTHR43270:SF4	RE11562P
P00005	Angiogenesis	P00240	FRS-2	PANTR|Ensembl=ENSPTRG00000005207|UniProtKB=H2Q6G0	Fibroblast growth factor receptor substrate 2	ISS	12571252	PubMed	PTHR21258:SF40	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000009389|UniProtKB=F7HEV7	Uncharacterized protein	ISS	11259498	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00646	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	8262392	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04393	Ras Pathway	P04558	p38	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	IDA	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00059	p53 pathway	P01486	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2522|UniProtKB=P30729	D(4) dopamine receptor	IDA	1319557	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00029	Huntington disease	P00807	Actin	RAT|RGD=1309504|UniProtKB=D3ZRN3	Protein Actbl2	ISS	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MOUSE|MGI=MGI=95390|UniProtKB=P09066	Homeobox protein engrailed-2	IEP	12356903	PubMed	PTHR24341:SF5	HOMEOBOX PROTEIN ENGRAILED-2
P00010	B cell activation	P00402	Jnk	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00056	VEGF signaling pathway	P01417	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00631	Grb2	MOUSE|MGI=MGI=1918770|UniProtKB=Q9CX99	GRB2-related adapter protein	ISS	8647802	PubMed	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P00018	EGF receptor signaling pathway	P00552	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00053	T cell activation	P01316	MHC-antigen	RAT|RGD=1593283|UniProtKB=Q6MG98	Histocompatibility 2, class II antigen E alpha	IPI	73139	PubMed	PTHR19944:SF63	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	MOUSE|MGI=MGI=2443028|UniProtKB=Q8C176	Transcription initiation factor TFIID subunit 2	ISS			PTHR15137:SF9	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2
P00015	Circadian clock system	G01501	cry	CANLF|Ensembl=ENSCAFG00000009379|UniProtKB=F1PNC9	Uncharacterized protein	ISS	10217146	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	CHICK|Ensembl=ENSGALG00000015176|UniProtKB=F1NU41	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P02738	De novo purine biosynthesis	P02903	Phosphoribosylglycinamide  formyltransferase	PYRAE|EnsemblGenome=PAE0219|UniProtKB=Q8ZZK2	Phosphoribosylglycinamide formyltransferase	ISS			PTHR43369:SF2	PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00020	FAS signaling pathway	P00596	Caspase6	RAT|RGD=70967|UniProtKB=O35397	Caspase-6	ISS	11463840	PubMed	PTHR10454:SF164	CASPASE-6
P02746	Heme biosynthesis	P02973	Uroporphyrinogen methyltransferase	BACSU|EnsemblGenome=BSU15610|UniProtKB=O34744	Uroporphyrinogen-III C-methyltransferase	ISS			PTHR21091:SF138	SUBFAMILY NOT NAMED
P00030	Hypoxia response via HIF activation	P00823	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	RCA	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00539	14-3-3	MOUSE|MGI=MGI=109194|UniProtKB=P68510	14-3-3 protein eta	IGI	10407019	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00057	Wnt signaling pathway	P01451	Galpha	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	IDA	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00010	B cell activation	P00371	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IGI	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05913	Enkephalin release	P05978	AC	MOUSE|MGI=MGI=102891|UniProtKB=P51829	Adenylate cyclase type 7	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00036	Interleukin signaling pathway	P00990	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00017	DNA replication	P00527	Histones	MACMU|Ensembl=ENSMMUG00000032354|UniProtKB=F6TK66	Histone H3	ISS	12413958	PubMed	PTHR11426:SF161	HISTONE H3.2-RELATED
P00036	Interleukin signaling pathway	P00965	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04552	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IDA	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00049	Parkinson disease	P01211	ERK	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	IDA	6319455	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05731	GABA-B receptor II signaling	P05754	Ggamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	91298951	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	NEUCR|EnsemblGenome=EFNCRG00000000529|UniProtKB=O13492	Folylpolyglutamate synthase	ISS			PTHR11136:SF4	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00947	Laminin	BOVIN|Ensembl=ENSBTAG00000003183|UniProtKB=A7MB18	NTN4 protein	ISS	2538453	PubMed	PTHR10574:SF282	NETRIN-4
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=2136757|UniProtKB=Q91Y01	MCG141286	IDA	8120095	PubMed	PTHR24028:SF91	PROTOCADHERIN BETA-11
P00054	Toll receptor signaling pathway	P01375	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	IDA	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	CANLF|Ensembl=ENSCAFG00000024958|UniProtKB=E2RG11	Uncharacterized protein	ISS	11821900	PubMed	PTHR10489:SF773	C-C CHEMOKINE RECEPTOR TYPE 10
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9441|UniProtKB=P51817	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00036	Interleukin signaling pathway	P00996	STAT	PANTR|Ensembl=ENSPTRG00000009199|UniProtKB=H2QD19	Signal transducer and activator of transcription	ISS	10835485	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ARATH|TAIR=AT5G59370|UniProtKB=P53494	Actin-4	IC	10974003	PubMed	PTHR11937:SF366	ACTIN-4
P00053	T cell activation	P01300	ERK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04455	beta-endorphin	MACMU|Ensembl=ENSMMUG00000016463|UniProtKB=F7GBI0	Uncharacterized protein	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	HUMAN|HGNC=20771|UniProtKB=P68371	Tubulin beta-4B chain	ISS	12932731	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	CAEBR|Gene=CBG02247|UniProtKB=A8WS68	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P04393	Ras Pathway	P04558	p38	BOVIN|Ensembl=ENSBTAG00000030182|UniProtKB=G3X793	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	BOVIN|Ensembl=ENSBTAG00000037616|UniProtKB=F1MUD1	Uncharacterized protein	ISS	12374786	PubMed	PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P00030	Hypoxia response via HIF activation	P00824	PTEN	TAKRU|Ensembl=ENSTRUG00000009851|UniProtKB=H2TJ90	Uncharacterized protein	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P02751	Lysine biosynthesis	P03011	N-succinyldiaminopimelate  aminotransferase	PSEAE|EnsemblGenome=PA0895|UniProtKB=O30508	Succinylornithine transaminase/acetylornithine aminotransferase	IDA	10074354	PubMed	PTHR11986:SF58	ALANINE--GLYOXYLATE AMINOTRANSFERASE 2, MITOCHONDRIAL
P00011	Blood coagulation	P00403	EPCR	HUMAN|HGNC=9452|UniProtKB=Q9UNN8	Endothelial protein C receptor	ISS	13626550	gi	PTHR15349:SF0	ENDOTHELIAL PROTEIN C RECEPTOR
P00049	Parkinson disease	P01242	Casein kinase I	MOUSE|MGI=MGI=1355272|UniProtKB=Q9DC28	Casein kinase I isoform delta	IDA	10617630	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P04392	P53 pathway feedback loops 1	G04685	p73DeltaN	BOVIN|Ensembl=ENSBTAG00000015460|UniProtKB=F1MKA9	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P05734	Synaptic vesicle trafficking	P05774	NSF	RAT|RGD=621594|UniProtKB=Q9QUL6	Vesicle-fusing ATPase	ISS	601633	OMIM	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IGI	10669416	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	IDA	9332390	PubMed	PTHR10202:SF13	PRESENILIN-2
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000024992|UniProtKB=F6TUR3	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	IC	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00260	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04663	Mdm2	HUMAN|HGNC=6974|UniProtKB=O15151	Protein Mdm4	ISS			PTHR13844:SF20	PROTEIN MDM4
P00021	FGF signaling pathway	P00641	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00047	PDGF signaling pathway	P01147	Nck	PANTR|Ensembl=ENSPTRG00000015434|UniProtKB=G2HHN0	Cytoplasmic protein NCK1	ISS	11689432	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00057	Wnt signaling pathway	P01428	Frizzled	MACMU|Ensembl=ENSMMUG00000004048|UniProtKB=F6ZR92	Frizzled-4	ISS	8717036	PubMed	PTHR11309:SF23	FRIZZLED-4
P00019	Endothelin signaling pathway	P00591	PLCbeta	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00029	Huntington disease	P00785	Cytochrome c	MACMU|Ensembl=ENSMMUG00000007149|UniProtKB=F7DMP6	Uncharacterized protein	ISS	9027315	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00029	Huntington disease	P00808	Caspase 8	RAT|RGD=620945|UniProtKB=Q9JHX4	Caspase-8	IDA	8681376	PubMed	PTHR10454:SF162	CASPASE-8
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00047	PDGF signaling pathway	P01162	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000007576|UniProtKB=H2QA92	Uncharacterized protein	ISS	12181435	PubMed	PTHR24229:SF20	SOMATOSTATIN RECEPTOR TYPE 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ORYSJ|EnsemblGenome=OS03G0285800|UniProtKB=Q10N20	Mitogen-activated protein kinase 5	ISS	8388749	PubMed	PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT3G45640|UniProtKB=Q39023	Mitogen-activated protein kinase 3	ISS	10514528	PubMed	PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00379	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	IGI	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00019	Endothelin signaling pathway	P00566	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MACMU|Ensembl=ENSMMUG00000018272|UniProtKB=F7HEB8	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	8837781	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	HUMAN|HGNC=5286|UniProtKB=P08908	5-hydroxytryptamine receptor 1A	ISS	12181435	PubMed	PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	RCA	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00919	Arf6	TAKRU|Ensembl=ENSTRUG00000017307|UniProtKB=H2VAQ1	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P04393	Ras Pathway	P04558	p38	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	IDA	8925912	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04398	p53 pathway feedback loops 2	P04657	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04570	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00034	Integrin signalling pathway	P00923	Arf1	MONDO|Ensembl=ENSMODG00000003056|UniProtKB=F6PNX7	Uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00629	PP2A	ORYSJ|EnsemblGenome=OS03G0805300|UniProtKB=Q10BT5	Serine/threonine-protein phosphatase PP2A-2 catalytic subunit	ISS			PTHR11668:SF318	SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-4 CATALYTIC SUBUNIT
P00060	Ubiquitin proteasome pathway	P01492	E1	ARATH|TAIR=AT2G21470|UniProtKB=Q9SJT1	SUMO-activating enzyme subunit 2	ISS			PTHR10953:SF5	SUMO-ACTIVATING ENZYME SUBUNIT 2
P04395	Vasopressin synthesis	P04597	Signal Peptide	TAKRU|Ensembl=ENSTRUG00000015631|UniProtKB=H2USP0	Uncharacterized protein	ISS	3768139	PubMed	PTHR11681:SF14	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	DANRE|ZFIN=ZDB-GENE-980526-527|UniProtKB=B3DJ37	Receptor protein serine/threonine kinase	TAS	10683140	PubMed	PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P00011	Blood coagulation	P00428	alpha2-antiplasmin	HUMAN|HGNC=9075|UniProtKB=P08697	Alpha-2-antiplasmin	ISS	11386143	gi	PTHR11461:SF20	ALPHA-2-ANTIPLASMIN
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04566	Stat 1/3	HUMAN|HGNC=11364|UniProtKB=P40763	Signal transducer and activator of transcription 3	IDA	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_114958|UniProtKB=C3XZ13	Putative uncharacterized protein	ISS			PTHR11937:SF359	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	XENTR|Xenbase=XB-GENE-484322|UniProtKB=F6RPG1	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF22	FRIZZLED-3
P00036	Interleukin signaling pathway	P00990	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g239788|UniProtKB=A7RPI8	Predicted protein	ISS	7514101	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00054	Toll receptor signaling pathway	P01368	MKK2	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P02747	Histidine biosynthesis	P02988	Histidinal dehydrogenase	LEPIN|EnsemblGenome=LA_2515|UniProtKB=Q8F393	Histidinol dehydrogenase	ISS			PTHR21256:SF2	HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00006	Apoptosis signaling pathway	P00260	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	BOVIN|Ensembl=ENSBTAG00000008409|UniProtKB=Q2HJ27	Myc proto-oncogene protein	ISS	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=620657|UniProtKB=Q8R508	Protocadherin Fat 3	IDA	8120095	PubMed	PTHR24026:SF49	PROTOCADHERIN FAT 3
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	RAT|RGD=1309318|UniProtKB=D4A3N4	Adenylate cyclase 1 (Predicted)	ISS	2491850	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ANOGA|EnsemblGenome=AGAP001676|UniProtKB=Q7PXZ8	AGAP001676-PA	ISS	11889126	PubMed	PTHR11937:SF368	ACTIN, INDIRECT FLIGHT MUSCLE
P00019	Endothelin signaling pathway	P00591	PLCbeta	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000002016|UniProtKB=F1P3G1	Protein kinase C delta type	IC	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=2685045|UniProtKB=E9QAN8	Protein Pik3c2b	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	10693759	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00010	B cell activation	P00379	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IPI	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	RAT|RGD=1303282|UniProtKB=Q6MG89	Notch homolog 4, [Drosophila]	ISS	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00046	Oxidative stress response	P01129	JNK1/2	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00012	Cadherin signaling pathway	P00474	Wnt	MACMU|Ensembl=ENSMMUG00000006921|UniProtKB=F7EV26	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	IC	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00050	Plasminogen activating cascade	P01255	Plasminogen	HUMAN|HGNC=9071|UniProtKB=P00747	Plasminogen	IDA	130317	gi	PTHR24261:SF6	PLASMINOGEN
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	PANTR|Ensembl=ENSPTRG00000003699|UniProtKB=H2Q3R5	Syntaxin 3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00010	B cell activation	P00375	Calmodulin	DAPPU|EnsemblGenome=DAPPUDRAFT_442795|UniProtKB=E9H5Z2	Calmodulin	ISS			PTHR23050:SF245	AT16150P-RELATED
P00049	Parkinson disease	P01208	Hsp70	DICDI|dictyBase=DDB_G0276445|UniProtKB=Q8T869	Luminal-binding protein 2	IDA	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00005	Angiogenesis	P00206	Wnt	MOUSE|MGI=MGI=98961|UniProtKB=P24383	Protein Wnt-7a	ISS	8717036	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00005	Angiogenesis	P00221	JNK1	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00014	Cholesterol biosynthesis	P00493	Geranyl trans-transferase	MACMU|Ensembl=ENSMMUG00000023144|UniProtKB=F7FI27	Farnesyl pyrophosphate synthase isoform a	ISS	O64905	SPACC	PTHR11525:SF0	FARNESYL PYROPHOSPHATE SYNTHASE
P00005	Angiogenesis	P00205	GAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00030	Hypoxia response via HIF activation	P00824	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	HUMAN|HGNC=2459|UniProtKB=P19784	Casein kinase II subunit alpha'	IDA	10806215	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00047	PDGF signaling pathway	P01160	IP3 receptor	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02772	Pyruvate metabolism	P03140	Pyruvate Carboxylase	PANTR|Ensembl=ENSPTRG00000023133|UniProtKB=H2R399	Pyruvate carboxylase	ISS	8048912	PubMed	PTHR43778:SF2	PYRUVATE CARBOXYLASE, MITOCHONDRIAL
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000009085|UniProtKB=H2RDQ2	Uncharacterized protein	ISS	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000012922|UniProtKB=H2QJF2	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00052	TGF-beta signaling pathway	P01284	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00638	PLCgamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	RCA	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	LEIMA|EnsemblGenome=LmjF.35.3960|UniProtKB=E9AFM1	Protein kinase A catalytic subunit isoform 2	ISS	14744463	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	HUMAN|HGNC=4573|UniProtKB=P42263	Glutamate receptor 3	ISS	12871085	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	3045562	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00059	p53 pathway	P01486	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	MONDO|Ensembl=ENSMODG00000016680|UniProtKB=F7DMI7	Uncharacterized protein	ISS	7637782	PubMed	PTHR11647:SF56	DIHYDROPYRIMIDINASE-RELATED PROTEIN 2
P00029	Huntington disease	P00807	Actin	ANOGA|EnsemblGenome=AGAP000651|UniProtKB=P84185	Actin-5C	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00006	Apoptosis signaling pathway	P00292	IkappaB	HUMAN|HGNC=7797|UniProtKB=P25963	NF-kappa-B inhibitor alpha	ISS	10811867	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00010	B cell activation	P00371	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00052	TGF-beta signaling pathway	P01275	P38	DANRE|ZFIN=ZDB-GENE-990415-257|UniProtKB=O42376	Mitogen-activated protein kinase 12	TAS	11707292	PubMed	PTHR24055:SF339	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04376	5HT4 type receptor mediated signaling pathway	P04427	5HT4 Receptor	RAT|RGD=2850|UniProtKB=Q62758	5-hydroxytryptamine receptor 4	ISS	12181435	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MOUSE|MGI=MGI=88396|UniProtKB=P12657	Muscarinic acetylcholine receptor M1	TAS	11166329	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04553	PAK	ORNAN|Ensembl=ENSOANG00000002406|UniProtKB=F7BAS2	Uncharacterized protein	ISS	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00059	p53 pathway	P04623	CBP	MACMU|Ensembl=ENSMMUG00000000893|UniProtKB=F6T7D0	Histone acetyltransferase p300	ISS	10823891	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00060	Ubiquitin proteasome pathway	P01491	E2	MONDO|Ensembl=ENSMODG00000003406|UniProtKB=F6Z075	Uncharacterized protein	ISS			PTHR24067:SF154	UBIQUITIN-CONJUGATING ENZYME E2 G2
P02770	Pyridoxal phosphate salvage pathway	P03121	Pyridoxal kinase	RAT|RGD=621324|UniProtKB=O35331	Pyridoxal kinase	ISS	20344886	gi	PTHR10534:SF2	PYRIDOXAL KINASE
P00057	Wnt signaling pathway	P01455	Smad4	HUMAN|HGNC=6771|UniProtKB=Q99717	Mothers against decapentaplegic homolog 5	ISS	9395284	PubMed	PTHR13703:SF36	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	DANRE|ZFIN=ZDB-GENE-010705-1|UniProtKB=Q90Z40	Guanine nucleotide-binding protein subunit gamma	IC	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00029	Huntington disease	P00796	Kainate receptor	HUMAN|HGNC=4581|UniProtKB=Q13003	Glutamate receptor ionotropic, kainate 3	IDA	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P06959	CCKR signaling map	P07228	MAPK1/3	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	RCA	12706116	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	CAEEL|WormBase=WBGene00001604|UniProtKB=Q9U307	Glutamine synthetase	ISS			PTHR20852:SF64	GLUTAMINE SYNTHETASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06861	MAP4Ks	MOUSE|MGI=MGI=1346883|UniProtKB=Q61161	Mitogen-activated protein kinase kinase kinase kinase 2	RCA			PTHR24361:SF392	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 2
P04393	Ras Pathway	P04570	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00121	CD44 intracellular fragment	MOUSE|MGI=MGI=88338|UniProtKB=P15379	CD44 antigen	IDA	14871815	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P05916	Opioid prodynorphin pathway	P06002	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	8170357	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00702	CPB	RAT|RGD=1308152|UniProtKB=Q5FVM5	Cyclic AMP-responsive element-binding protein 3-like protein 3	ISS			PTHR22952:SF98	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01188	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P05913	Enkephalin release	P05974	G-Protein (i)	DAPPU|EnsemblGenome=DAPPUDRAFT_59367|UniProtKB=E9H7Z0	Guanine nucleotide-binding protein G(O) subunit alpha 1	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04557	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P02721	ATP synthesis	P02798	Cyt C	BOVIN|Ensembl=ENSBTAG00000022613|UniProtKB=P62894	Cytochrome c	TAS	5968568	PubMed	PTHR11961:SF15	CYTOCHROME C
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01375	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00036	Interleukin signaling pathway	P00977	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	BOVIN|Ensembl=ENSBTAG00000003835|UniProtKB=Q2KJH1	Bone morphogenetic protein 4	ISS	9759503	PubMed	PTHR11848:SF165	BONE MORPHOGENETIC PROTEIN 4
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	CANLF|Ensembl=ENSCAFG00000007966|UniProtKB=F1Q270	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF138	MATRIX METALLOPROTEINASE-24
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	MOUSE|MGI=MGI=109284|UniProtKB=Q61144	Presenilin-2	TAS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00034	Integrin signalling pathway	P00944	Actin	PANTR|Ensembl=ENSPTRG00000018890|UniProtKB=Q5R1X3	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	RAT|RGD=620967|UniProtKB=F1M9D0	Protein Map3k2	ISS	21735556	gi	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Gene=DRD2|UniProtKB=P60026	D(2) dopamine receptor	ISS	11248120	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00045	Notch signaling pathway	P01117	Neuralized	MOUSE|MGI=MGI=3043305|UniProtKB=Q9D0S4	Neuralized-like protein 2	RCA			PTHR12429:SF8	NEURALIZED-LIKE PROTEIN 2
P05913	Enkephalin release	P05974	G-Protein (i)	CHICK|Ensembl=ENSGALG00000001334|UniProtKB=F1NLV4	Uncharacterized protein	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00052	TGF-beta signaling pathway	P01284	JNK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00025	Hedgehog signaling pathway	P00682	PKA	EMENI|EnsemblGenome=CADANIAG00005408|UniProtKB=O59922	cAMP-dependent protein kinase regulatory subunit	ISS	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P06217	Toll pathway-drosophila	P06341	SPN27A	DROME|FlyBase=FBgn0028990|UniProtKB=Q9V3N1	LD24467p	TAS	14667416	PubMed	PTHR11461:SF46	LD24467P
P00053	T cell activation	P01306	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	CAEEL|WormBase=WBGene00001679|UniProtKB=P17343	Guanine nucleotide-binding protein subunit beta-1	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00007	Axon guidance mediated by semaphorins	P00341	Rho	CHICK|Ensembl=ENSGALG00000003806|UniProtKB=O93467	GTP-binding protein	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00021	FGF signaling pathway	P00631	Grb2	BOVIN|Ensembl=ENSBTAG00000003707|UniProtKB=A6QLK6	GRB2-related adapter protein	ISS	9741627	PubMed	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00036	Interleukin signaling pathway	P00967	c-fos	MONDO|Ensembl=ENSMODG00000005927|UniProtKB=F6WX28	Uncharacterized protein	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04395	Vasopressin synthesis	P04589	Signal Peptidase	MOUSE|MGI=MGI=1913874|UniProtKB=Q9CYN2	Signal peptidase complex subunit 2	ISS	2092035	PubMed	PTHR13085:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 2
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P02748	Isoleucine biosynthesis	P02997	Acetolactate synthase	AQUAE|EnsemblGenome=aq_451|UniProtKB=O66759	Acetolactate synthase	ISS			PTHR18968:SF116	ACETOLACTATE SYNTHASE ISOZYME 3 LARGE SUBUNIT
P00012	Cadherin signaling pathway	P00472	Tyrosine phosphatases	RAT|RGD=61965|UniProtKB=P20417	Tyrosine-protein phosphatase non-receptor type 1	ISS			PTHR19134:SF239	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1
P00010	B cell activation	P00384	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	SCHPO|PomBase=SPAC806.07|UniProtKB=P49740	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02733	Carnitine metabolism	P02866	Carnitine dehydratase	STRCO|Gene=CAB52867|UniProtKB=Q9S2Y3	Uncharacterized protein	ISS			PTHR43949:SF1	ACETYL-COA:OXALATE COA-TRANSFERASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00047	PDGF signaling pathway	P01151	PKB	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00017	DNA replication	P00533	Pol delta	RAT|RGD=621839|UniProtKB=O54747	DNA polymerase delta catalytic subunit	ISS	9620226	PubMed	PTHR10322:SF23	DNA POLYMERASE DELTA CATALYTIC SUBUNIT
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	CANLF|Ensembl=ENSCAFG00000006453|UniProtKB=F6X958	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00060	Ubiquitin proteasome pathway	P01491	E2	NEUCR|EnsemblGenome=EFNCRG00000003458|UniProtKB=Q1K7R0	Ubiquitin-conjugating enzyme E	ISS			PTHR24067:SF154	UBIQUITIN-CONJUGATING ENZYME E2 G2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00020	FAS signaling pathway	P00593	Caspase9	MOUSE|MGI=MGI=1277950|UniProtKB=Q8C3Q9	Caspase-9	IGI	9390557	PubMed	PTHR10454:SF157	CASPASE-9
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	HUMAN|HGNC=286|UniProtKB=P07550	Beta-2 adrenergic receptor	IDA	12063255	PubMed	PTHR24248:SF21	BETA-2 ADRENERGIC RECEPTOR
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CANLF|Ensembl=ENSCAFG00000001738|UniProtKB=E2RDG9	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00056	VEGF signaling pathway	P01413	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	15737619	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P02747	Histidine biosynthesis	P02988	Histidinal dehydrogenase	BACSU|EnsemblGenome=BSU34910|UniProtKB=O34651	Histidinol dehydrogenase	ISS			PTHR21256:SF2	HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN
P00036	Interleukin signaling pathway	P00977	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00029	Huntington disease	P00790	beta-Tubulin	PHYPA|Gene=PHYPADRAFT_165677|UniProtKB=Q6TYR3	Beta-tubulin 5	ISS	12932731	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00865	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00012	Cadherin signaling pathway	P00470	F-actin	TRIAD|EnsemblGenome=TriadG35956|UniProtKB=Q7YTV5	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	RAT|RGD=61862|UniProtKB=P19491	Glutamate receptor 2	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00056	VEGF signaling pathway	P01407	Erk	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=1930780|UniProtKB=Q61879	Myosin-10	ISS	89264452	PubMed	PTHR13140:SF328	MYOSIN-10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CANLF|Ensembl=ENSCAFG00000018564|UniProtKB=E2RHU1	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MACMU|Ensembl=ENSMMUG00000012164|UniProtKB=F7GW57	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00047	PDGF signaling pathway	P01153	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	IDA	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00053	T cell activation	P01324	rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02734	Chorismate biosynthesis	P02873	Shikimate dehydrogenase	CHLTR|EnsemblGenome=CT_370|UniProtKB=O84375	Shikimate biosynthesis protein AroDE	ISS			PTHR43699:SF1	3-DEHYDROQUINATE DEHYDRATASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00029	Huntington disease	P00775	Rac	ORYSJ|EnsemblGenome=OS02G0120800|UniProtKB=Q6ZHA3	Rac-like GTP-binding protein 6	ISS			PTHR24072:SF261	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00736	CalDAG-GEF	HUMAN|HGNC=9878|UniProtKB=O95267	RAS guanyl-releasing protein 1	IDA	10835426	PubMed	PTHR23113:SF174	RAS GUANYL-RELEASING PROTEIN 1
P00029	Huntington disease	P00790	beta-Tubulin	DAPPU|EnsemblGenome=DAPPUDRAFT_305638|UniProtKB=E9FWY0	Putative uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF252	BETA-TUBULIN AT 97EF, ISOFORM B
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DANRE|ZFIN=ZDB-GENE-030131-6503|UniProtKB=Q7ZUC5	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF297	PROTEIN KINASE C DELTA TYPE
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000001384|UniProtKB=F7GL73	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	BOVIN|Ensembl=ENSBTAG00000044059|UniProtKB=F1MF20	Uncharacterized protein	ISS			PTHR18945:SF768	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-10
P00048	PI3 kinase pathway	P01192	p110	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06716	MT1-MMP	MOUSE|MGI=MGI=101900|UniProtKB=P53690	Matrix metalloproteinase-14	RCA	12834808	PubMed	PTHR10201:SF24	MATRIX METALLOPROTEINASE-14
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01311	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IDA	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00634	MEKK1-5	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	ISS	12168099	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001749|UniProtKB=H2Q0Q4	Uncharacterized protein	ISS	14507926	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00056	VEGF signaling pathway	P01409	cPLA2	BOVIN|Ensembl=ENSBTAG00000013298|UniProtKB=A4IFJ5	Cytosolic phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	HUMAN|HGNC=3025|UniProtKB=P21917	D(4) dopamine receptor	IDA	2039532	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	11832947	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DROME|FlyBase=FBgn0000046|UniProtKB=P10981	Actin-87E	IC	10974003	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00029	Huntington disease	P00805	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00624	14-3-3	MACMU|Ensembl=ENSMMUG00000013206|UniProtKB=F6XFG9	14-3-3 protein beta/alpha	ISS	12618428	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00050	Plasminogen activating cascade	P01254	pro-MMP-13	CANLF|Ensembl=ENSCAFG00000015043|UniProtKB=F1PVS9	Uncharacterized protein	TAS	Fang,Y.,Kitchell,B.E.,Paria,B.andBalkin,R.	free text	PTHR10201:SF165	COLLAGENASE 3
P00049	Parkinson disease	P01208	Hsp70	LEIMA|EnsemblGenome=LmjF.28.2770|UniProtKB=Q4Q7Y4	Putative heat-shock protein hsp70	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000000658|UniProtKB=F6WZD8	Uncharacterized protein	ISS	8120095	PubMed	PTHR44506:SF1	CADHERIN-RELATED FAMILY MEMBER 1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00018	EGF receptor signaling pathway	P00540	MKK3,6	RAT|RGD=1306620|UniProtKB=B1H230	Map2k3 protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00034	Integrin signalling pathway	P00936	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IPI	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00114	actin	TAKRU|Ensembl=ENSTRUG00000014318|UniProtKB=H2UI49	Uncharacterized protein	IDA	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01093	AChE	CAEEL|WormBase=WBGene00000038|UniProtKB=G5EDN1	Carboxylic ester hydrolase	IC			PTHR43918:SF2	CARBOXYLIC ESTER HYDROLASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00010	B cell activation	P00373	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00058	mRNA splicing	P01473	U6	YEAST|SGD=S000002881|UniProtKB=Q03338	U4/U6 small nuclear ribonucleoprotein PRP3	ISS	9169867	PubMed	PTHR14212:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3
P00012	Cadherin signaling pathway	P00474	Wnt	PANTR|Ensembl=ENSPTRG00000015034|UniProtKB=H2QMT4	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	PANTR|Gene=HTR1A|UniProtKB=Q9N298	5-hydroxytryptamine receptor 1A	ISS	12181435	PubMed	PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P00057	Wnt signaling pathway	P01440	Cadherin	MONDO|Ensembl=ENSMODG00000016675|UniProtKB=F7E6I8	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF81	CADHERIN-4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00023	General transcription regulation	P00670	TBP	HUMAN|HGNC=11589|UniProtKB=P62380	TATA box-binding protein-like protein 1	IGI	10082669	PubMed	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	HUMAN|HGNC=6855|UniProtKB=Q99759	Mitogen-activated protein kinase kinase kinase 3	IGI	8649450	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05913	Enkephalin release	P05972	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	MACMU|Ensembl=ENSMMUG00000004001|UniProtKB=F6XQZ0	Synaptotagmin-2	ISS	SYT2_RAT	SPACC	PTHR10024:SF223	SYNAPTOTAGMIN-2
P04393	Ras Pathway	P04541	p90RSK	HUMAN|HGNC=10431|UniProtKB=Q15349	Ribosomal protein S6 kinase alpha-2	IDA	1922062	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00020	FAS signaling pathway	P00602	DAXX	HUMAN|HGNC=2681|UniProtKB=Q9UER7	Death domain-associated protein 6	IGI	10698492	PubMed	PTHR12766:SF7	DEATH DOMAIN-ASSOCIATED PROTEIN 6
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00018	EGF receptor signaling pathway	P00551	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IGI	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00470	F-actin	CHICK|Gene=ACTG2|UniProtKB=P63270	Actin, gamma-enteric smooth muscle	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00029	Huntington disease	P00777	CBP	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00049	Parkinson disease	P01226	CDCrel-1	BOVIN|Ensembl=ENSBTAG00000021219|UniProtKB=A5PJU9	Septin-1	ISS			PTHR18884:SF6	SEPTIN-1
P05731	GABA-B receptor II signaling	P05754	Ggamma	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00007	Axon guidance mediated by semaphorins	P00331	PAK	CANLF|Ensembl=ENSCAFG00000004956|UniProtKB=E2REH3	Uncharacterized protein	ISS	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	CHICK|Ensembl=ENSGALG00000012617|UniProtKB=Q06900	Receptor protein serine/threonine kinase	TAS	9395284	PubMed	PTHR23255:SF61	TGF-BETA RECEPTOR TYPE-1
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CANLF|Ensembl=ENSCAFG00000013132|UniProtKB=E2REG1	Uncharacterized protein	ISS	10664585	PubMed	PTHR23351:SF6	FOS-RELATED ANTIGEN 1
P05913	Enkephalin release	P05977	G-Protein (s)	HUMAN|HGNC=4388|UniProtKB=P38405	Guanine nucleotide-binding protein G(olf) subunit alpha	IC			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05917	Opioid proopiomelanocortin pathway	P06011	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00551	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IGI	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MONDO|Ensembl=ENSMODG00000008900|UniProtKB=F7B4C1	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05913	Enkephalin release	P05972	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	MOUSE|MGI=MGI=99673|UniProtKB=P84309	Adenylate cyclase type 5	ISS	1409703	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00029	Huntington disease	P00807	Actin	CAEEL|WormBase=WBGene00000063|UniProtKB=P0DM41	Actin-1	IDA	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	PANTR|Gene=CHRM3|UniProtKB=Q9N2A4	Muscarinic acetylcholine receptor M3	IDA	11166329	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00029	Huntington disease	P00807	Actin	DANRE|ZFIN=ZDB-GENE-000329-3|UniProtKB=Q7ZVF9	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00036	Interleukin signaling pathway	P00962	ELK	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	11050086	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000012820|UniProtKB=F1MDL3	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00021	FGF signaling pathway	P00638	PLCgamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00037	Ionotropic glutamate receptor pathway	P01026	KA	BOVIN|Ensembl=ENSBTAG00000033153|UniProtKB=F1MG21	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00047	PDGF signaling pathway	P01162	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PANTR|Ensembl=ENSPTRG00000009762|UniProtKB=H2QE24	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00053	T cell activation	P01297	MEKK	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	RCA	12168099	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00057	Wnt signaling pathway	P01444	Wnt	MONDO|Ensembl=ENSMODG00000013820|UniProtKB=F6SF10	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	PANTR|Ensembl=ENSPTRG00000014976|UniProtKB=H2R892	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	TAKRU|Ensembl=ENSTRUG00000011297|UniProtKB=H2TV18	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	CHICK|Ensembl=ENSGALG00000017238|UniProtKB=F1NWG3	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CAEBR|Gene=CBG05858|UniProtKB=A8X1H0	Protein CBR-EGL-19 (Fragment)	ISS	10514528	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P02754	Methylcitrate cycle	P03030	Acetyl-CoA synthetase	ECOLI|EcoGene=EG13604|UniProtKB=P77495	Propionate--CoA ligase	ISS			PTHR43347:SF3	ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL
P00029	Huntington disease	P00807	Actin	TRIVA|Gene=TVAG_090470|UniProtKB=A2FA04	Actin	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=102705|UniProtKB=P63213	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00005	Angiogenesis	P00249	PAK	CHICK|Ensembl=ENSGALG00000000681|UniProtKB=E1C3P6	Uncharacterized protein	ISS	14580336	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00037	Ionotropic glutamate receptor pathway	P01012	PICK	CHICK|Ensembl=ENSGALG00000019313|UniProtKB=E1BQ62	Uncharacterized protein	ISS	12941441	PubMed	PTHR12141:SF1	PRKCA-BINDING PROTEIN
P00010	B cell activation	P00371	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	RCA			PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05916	Opioid prodynorphin pathway	P06001	AC	RAT|RGD=619966|UniProtKB=F1LQT1	Adenylate cyclase 7	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00021	FGF signaling pathway	P00634	MEKK1-5	MOUSE|MGI=MGI=1346876|UniProtKB=O35099	Mitogen-activated protein kinase kinase kinase 5	ISS	12697749	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01143	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	20027584	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00020	FAS signaling pathway	P00615	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=1306541|UniProtKB=D3ZVF3	Phosphoinositide-3-kinase, class 2, beta polypeptide (Predicted)	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	CHICK|Ensembl=ENSGALG00000003806|UniProtKB=O93467	GTP-binding protein	ISS	12039949	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P06664	Gonadotropin-releasing hormone receptor pathway	P06837	EGR1	MOUSE|MGI=MGI=95295|UniProtKB=P08046	Early growth response protein 1	RCA			PTHR44685:SF1	EARLY GROWTH RESPONSE PROTEIN 1
P00010	B cell activation	P00401	jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	P17325	SPACC	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00017	DNA replication	P00531	Pol alpha	MACMU|Ensembl=ENSMMUG00000018433|UniProtKB=F7HF26	DNA polymerase	ISS	14499601	PubMed	PTHR10322:SF21	DNA POLYMERASE ALPHA CATALYTIC SUBUNIT
P04393	Ras Pathway	P04565	MKK4/7	CHICK|Ensembl=ENSGALG00000001001|UniProtKB=F1P3T1	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00048	PI3 kinase pathway	P01177	P110ACT	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00203	Erk	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04546	GSK3	DICDI|dictyBase=DDB_G0272110|UniProtKB=P51136	Glycogen synthase kinase-3	IDA	7529201	PubMed	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	XENTR|Xenbase=XB-GENE-490883|UniProtKB=Q6NVA9	Actin, cytoplasmic 1	ISS	11889139	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00052	TGF-beta signaling pathway	P01275	P38	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	IDA	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	HUMAN|HGNC=4579|UniProtKB=P39086	Glutamate receptor ionotropic, kainate 1	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P05916	Opioid prodynorphin pathway	P06002	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	IDA	91056091	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2744|UniProtKB=P31422	Metabotropic glutamate receptor 3	IDA	12488551	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00049	Parkinson disease	P01216	Parkin	MACMU|Ensembl=ENSMMUG00000020410|UniProtKB=F6U1L3	E3 ubiquitin-protein ligase parkin	ISS	11078524	PubMed	PTHR11685:SF214	E3 UBIQUITIN-PROTEIN LIGASE PARKIN
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	DROME|FlyBase=FBgn0001123|UniProtKB=P20354	G protein alpha s subunit	ISS	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00045	Notch signaling pathway	P01120	NIcs	CANLF|Ensembl=ENSCAFG00000019633|UniProtKB=F1PDC7	Uncharacterized protein	ISS	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P05913	Enkephalin release	P05974	G-Protein (i)	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	IC	12488551	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-1712|UniProtKB=Q6PBY0	Guanine nucleotide binding protein (G protein), beta 5	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	TAKRU|Ensembl=ENSTRUG00000009851|UniProtKB=H2TJ90	Uncharacterized protein	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000012005|UniProtKB=F7H091	Metabotropic glutamate receptor 2 isoform a	ISS	9407094	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00007	Axon guidance mediated by semaphorins	P00340	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	12874273	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00005	Angiogenesis	P00206	Wnt	MOUSE|MGI=MGI=98958|UniProtKB=P22725	Protein Wnt-5a	ISS	11266476	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	IDA	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00005	Angiogenesis	P00211	GSK3beta	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00951	Jnk	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	IDA	10514528	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00638	PLCgamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00055	Transcription regulation by bZIP transcription factor	P01395	TFIIE	MOUSE|MGI=MGI=1921447|UniProtKB=Q9D0D5	General transcription factor IIE subunit 1	ISS	189962	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00047	PDGF signaling pathway	P01142	p90RSK	BOVIN|Ensembl=ENSBTAG00000014447|UniProtKB=A4IFF4	Ribosomal protein S6 kinase	ISS	12769834	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00047	PDGF signaling pathway	P01148	Grb2	RAT|RGD=1311085|UniProtKB=A0A0G2JZD5	Protein Gab1	ISS			PTHR12156:SF18	GRB2-ASSOCIATED-BINDING PROTEIN 1
P00048	PI3 kinase pathway	P01192	p110	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01173	STAT	PANTR|Ensembl=ENSPTRG00000009199|UniProtKB=H2QD19	Signal transducer and activator of transcription	ISS	10835485	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	MONDO|Ensembl=ENSMODG00000014256|UniProtKB=F6XJK0	Aspartate aminotransferase	ISS			PTHR11879:SF32	ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P02775	Salvage pyrimidine ribonucleotides	P03155	Cytosine deaminase	IXOSC|EnsemblGenome=ISCW020789|UniProtKB=B7PXR7	Putative uncharacterized protein (Fragment)	ISS			PTHR11079:SF149	TRNA-SPECIFIC ADENOSINE DEAMINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	RAT|RGD=3246|UniProtKB=Q63415	Proprotein convertase subtilisin/kexin type 6	IDA			PTHR42884:SF8	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 6
P00030	Hypoxia response via HIF activation	P00819	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00629	PP2A	DICPU|Gene=DICPUDRAFT_53645|UniProtKB=F0ZDS0	Serine/threonine-protein phosphatase	ISS			PTHR11668:SF24	SERINE/THREONINE-PROTEIN PHOSPHATASE 6 CATALYTIC SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00009	Axon guidance mediated by netrin	P00366	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00054	Toll receptor signaling pathway	P01375	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00648	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IC	15572354	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P02729	Ascorbate degradation	P02849	L-xylulose kinase	RHOBA|EnsemblGenome=RB12012|UniProtKB=Q7UJA9	Xylulose kinase	ISS			PTHR43095:SF5	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01438	PP2A	MONDO|Ensembl=ENSMODG00000014177|UniProtKB=F6U7A6	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00010	B cell activation	P00373	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01455	Smad4	MACMU|Ensembl=ENSMMUG00000018334|UniProtKB=F7H894	Mothers against decapentaplegic homolog	ISS	10693808	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	MOUSE|MGI=MGI=2446460|UniProtKB=G5E8H5	MCG118205, isoform CRA_c	ISS			PTHR12305:SF32	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE TPTE2-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00012	Cadherin signaling pathway	P00470	F-actin	IXOSC|EnsemblGenome=ISCW024111|UniProtKB=B7PBG2	Actin, putative (Fragment)	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DROME|FlyBase=FBgn0003093|UniProtKB=P13678	Protein kinase C	IC	15572354	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00036	Interleukin signaling pathway	P00973	PKB	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00819	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00038	JAK/STAT signaling pathway	P01031	PIAS	PANTR|Ensembl=ENSPTRG00000007210|UniProtKB=H2RH26	Uncharacterized protein	ISS	8682149	PubMed	PTHR10782:SF11	E3 SUMO-PROTEIN LIGASE PIAS1
P00030	Hypoxia response via HIF activation	P00823	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	7937853	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00036	Interleukin signaling pathway	P00979	MAPKAPK2	MOUSE|MGI=MGI=109298|UniProtKB=P49138	MAP kinase-activated protein kinase 2	IC	9628873	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00034	Integrin signalling pathway	P00910	Grb2	DANRE|ZFIN=ZDB-GENE-040426-1975|UniProtKB=Q6PC73	Growth factor receptor-bound protein 2	ISS	8479536	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	PANTR|Gene=IL2RA|UniProtKB=Q38IC8	Interleukin-2 receptor subunit alpha (Fragment)	ISS			PTHR10573:SF0	INTERLEUKIN-2 RECEPTOR SUBUNIT ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	MOUSE|MGI=MGI=96433|UniProtKB=Q60751	Insulin-like growth factor 1 receptor	ISS	11182407	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00005	Angiogenesis	P00249	PAK	RAT|RGD=3251|UniProtKB=Q62829	Serine/threonine-protein kinase PAK 3	ISS	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	MACMU|Ensembl=ENSMMUG00000009928|UniProtKB=F6Y5E5	Uncharacterized protein	ISS	2433589	PubMed	PTHR11767:SF17	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00005	Angiogenesis	P00226	Delta/Serrate	DROME|FlyBase=FBgn0004197|UniProtKB=P18168	Protein serrate	ISS			PTHR44097:SF2	PROTEIN SERRATE
P04384	Gamma-aminobutyric acid synthesis	P04481	Succinic semialdehyde dehydrogenase	MACMU|Ensembl=ENSMMUG00000019368|UniProtKB=F6T9P0	Uncharacterized protein	ISS	12891648	PubMed	PTHR43353:SF5	SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL
P06664	Gonadotropin-releasing hormone receptor pathway	P06850	PKCs(3)	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	RCA	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04427	5HT4 Receptor	MOUSE|MGI=MGI=109246|UniProtKB=P97288	5-hydroxytryptamine receptor 4	ISS	12181435	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P00019	Endothelin signaling pathway	P00588	ET1-4	MOUSE|MGI=MGI=95285|UniProtKB=P48299	Endothelin-3	ISS	9012511	PubMed	PTHR13874:SF11	ENDOTHELIN-3
P00001	Adrenaline and noradrenaline biosynthesis	P00068	amine translocator	HUMAN|HGNC=13622|UniProtKB=Q9GZN6	Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5	IC	12719981	PubMed	PTHR11616:SF113	ORPHAN SODIUM- AND CHLORIDE-DEPENDENT NEUROTRANSMITTER TRANSPORTER NTT5
P00037	Ionotropic glutamate receptor pathway	P01001	KA4	RAT|RGD=2734|UniProtKB=Q01812	Glutamate receptor ionotropic, kainate 4	IEA	12941441	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ANOGA|EnsemblGenome=AGAP001506|UniProtKB=Q7PXP3	AGAP001506-PA	IC	9754712	PubMed	PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	MOUSE|MGI=MGI=108007|UniProtKB=P48543	G protein-activated inward rectifier potassium channel 3	IDA	12374786	PubMed	PTHR11767:SF17	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 3
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01433	SIAH-1	MACMU|Ensembl=ENSMMUG00000007400|UniProtKB=F6T3K3	E3 ubiquitin-protein ligase	ISS	11389839	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	HUMAN|HGNC=7578|UniProtKB=P13535	Myosin-8	ISS	89264452	PubMed	PTHR13140:SF368	MYOSIN-8
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	YEAST|SGD=S000004362|UniProtKB=Q05933	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00053	T cell activation	P01336	Jnk	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P06664	Gonadotropin-releasing hormone receptor pathway	P06833	5-HT3AR	MOUSE|MGI=MGI=96282|UniProtKB=P23979	5-hydroxytryptamine receptor 3A	RCA	7509203	PubMed	PTHR18945:SF52	5-HYDROXYTRYPTAMINE RECEPTOR 3A
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	BOVIN|Ensembl=ENSBTAG00000004093|UniProtKB=Q6B856	Tubulin beta-2B chain	ISS	9454836	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00013	Cell cycle	P00480	Proteasome	CANLF|Ensembl=ENSCAFG00000006455|UniProtKB=E2R5N5	Uncharacterized protein	ISS	10225435	PubMed	PTHR10539:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13
P00022	General transcription by RNA polymerase I	P00657	TBP	MACMU|Ensembl=ENSMMUG00000019917|UniProtKB=F6SEF6	Uncharacterized protein	ISS	600075	OMIM	PTHR10126:SF20	TATA-BOX-BINDING PROTEIN
P00048	PI3 kinase pathway	P01188	Gbetagamma	XENTR|Xenbase=XB-GENE-977853|UniProtKB=F7EBE7	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=109356|UniProtKB=O09044	Synaptosomal-associated protein 23	IC	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	BOVIN|Gene=MMP14|UniProtKB=Q9GLE4	Matrix metalloproteinase-14	TAS	12834808	PubMed	PTHR10201:SF24	MATRIX METALLOPROTEINASE-14
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	PANTR|Gene=MYC|UniProtKB=P23583	Myc proto-oncogene protein	IEP	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00029	Huntington disease	P00796	Kainate receptor	ORNAN|Ensembl=ENSOANG00000010302|UniProtKB=F6TDQ6	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	STRPU|EnsemblGenome=SPU_012282|UniProtKB=W4Y969	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF369	ACTIN-42A
P02729	Ascorbate degradation	P02849	L-xylulose kinase	BACSU|EnsemblGenome=BSU17610|UniProtKB=P39211	Xylulose kinase	ISS			PTHR43095:SF5	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IGI	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	PANTR|Ensembl=ENSPTRG00000013189|UniProtKB=H2QJV1	Uncharacterized protein	ISS	1706187	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DAPPU|EnsemblGenome=DAPPUDRAFT_59367|UniProtKB=E9H7Z0	Guanine nucleotide-binding protein G(O) subunit alpha 1	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00053	T cell activation	P01336	Jnk	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00017	DNA replication	P00536	DNA Topisomerase	HUMAN|HGNC=11986|UniProtKB=P11387	DNA topoisomerase 1	ISS			PTHR10290:SF5	DNA TOPOISOMERASE 1
P00010	B cell activation	P00401	jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00047	PDGF signaling pathway	P01153	GSK3	ARATH|TAIR=AT1G57870|UniProtKB=Q9FVS6	Shaggy-related protein kinase delta	ISS	7529201	PubMed	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MACMU|Ensembl=ENSMMUG00000032222|UniProtKB=F7FW05	Uncharacterized protein	ISS	12181435	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00005	Angiogenesis	P00256	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04397	p53 pathway by glucose deprivation	P04641	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00925	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IDA	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	TAS	10514528	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00045	Notch signaling pathway	P01105	TACE	PANTR|Ensembl=ENSPTRG00000007116|UniProtKB=H2Q9I4	ADAM metallopeptidase domain 10	ISS			PTHR11905:SF4	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 10
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00022	General transcription by RNA polymerase I	P00657	TBP	YEAST|SGD=S000000950|UniProtKB=P13393	TATA-box-binding protein	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	XENTR|Xenbase=XB-GENE-957124|UniProtKB=F7BDN8	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00004	Alzheimer disease-presenilin pathway	P00118	E-cadherin	MOUSE|MGI=MGI=88356|UniProtKB=P10287	Cadherin-3	IDA	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P00036	Interleukin signaling pathway	P00997	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	7798194	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00006	Apoptosis signaling pathway	P00269	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10875333	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IGI	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00047	PDGF signaling pathway	P01142	p90RSK	BOVIN|Ensembl=ENSBTAG00000039153|UniProtKB=F1MQE1	Ribosomal protein S6 kinase	ISS	9792677	PubMed	PTHR24351:SF41	RIBOSOMAL PROTEIN S6 KINASE ALPHA-4
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	RAT|RGD=67385|UniProtKB=Q8VGC3	Voltage-dependent L-type calcium channel subunit beta-2	IC	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00014	Cholesterol biosynthesis	P00490	Dimethylallyl trans-transferase	PANTR|Ensembl=ENSPTRG00000002130|UniProtKB=H2Q1D7	Geranylgeranyl diphosphate synthase 1	RCA			PTHR12001:SF44	GERANYLGERANYL PYROPHOSPHATE SYNTHASE
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00564	Rac	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS	12606638	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00018	EGF receptor signaling pathway	P00560	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05970	TH	BOVIN|Gene=TH|UniProtKB=P17289	Tyrosine 3-monooxygenase	ISS	12480184	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IDA	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	88318957	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	THEMA|EnsemblGenome=TM_0943|UniProtKB=P36205	Glutamine synthetase	ISS			PTHR43785:SF1	TYPE-1 GLUTAMINE SYNTHETASE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00037	Ionotropic glutamate receptor pathway	P01026	KA	CHICK|Ensembl=ENSGALG00000006638|UniProtKB=R4GGL9	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P02747	Histidine biosynthesis	P02990	Histidinol-phosphatase	YEAST|SGD=S000001921|UniProtKB=P38635	Histidinol-phosphatase	ISS			PTHR21039:SF0	HISTIDINOL-PHOSPHATASE
P00021	FGF signaling pathway	P00648	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	2837282	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MOUSE|MGI=MGI=104616|UniProtKB=P51678	Probable C-C chemokine receptor type 3	ISS			PTHR10489:SF649	C-C CHEMOKINE RECEPTOR TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P06215	MYO signaling pathway	P06318	FUR1	DROME|FlyBase=FBgn0004509|UniProtKB=P26016	Furin-like protease 1, isoforms 1/1-X/2	IEA	7737999	PubMed	PTHR42884:SF3	FURIN-LIKE PROTEASE 1, ISOFORMS 1/1-X/2
P06959	CCKR signaling map	G07280	CCND1	HUMAN|HGNC=1582|UniProtKB=P24385	G1/S-specific cyclin-D1	RCA	18515095	PubMed	PTHR10177:SF67	G1/S-SPECIFIC CYCLIN-D1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00010	B cell activation	P00383	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	CANLF|Ensembl=ENSCAFG00000003821|UniProtKB=E2RT60	Integrin beta	ISS	10706722	PubMed	PTHR10082:SF28	INTEGRIN BETA-1
P06587	Nicotine pharmacodynamics pathway	P06596	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12748278	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00059	p53 pathway	G01579	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	IC	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04393	Ras Pathway	P04558	p38	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	IDA	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00047	PDGF signaling pathway	P01161	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00053	T cell activation	P01332	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IDA	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00384	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00005	Angiogenesis	P00203	Erk	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00019	Endothelin signaling pathway	P00589	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00627	ERK1-2	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01451	Galpha	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IDA	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	15572354	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04397	p53 pathway by glucose deprivation	P04641	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01412	HSP27	HUMAN|HGNC=2389|UniProtKB=P02511	Alpha-crystallin B chain	ISS			PTHR11527:SF37	ALPHA-CRYSTALLIN B CHAIN
P00019	Endothelin signaling pathway	P00582	COX-2	PANTR|Ensembl=ENSPTRG00000001786|UniProtKB=H2Q0S9	Prostaglandin-endoperoxide synthase 2 (Prostaglandin G/H synthase and cyclooxygenase)	ISS	12871860	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	MONDO|Ensembl=ENSMODG00000016960|UniProtKB=F6V5G0	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	3755548	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	CHICK|Gene=CSNK1A1|UniProtKB=P67962	Casein kinase I isoform alpha	IDA	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P05916	Opioid prodynorphin pathway	P06002	G-protein	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00034	Integrin signalling pathway	P00906	Rap1	DANRE|ZFIN=ZDB-GENE-030131-9662|UniProtKB=Q6TEN1	Ras-related protein Rap-1b	ISS	1904317	PubMed	PTHR24070:SF382	RAS-RELATED PROTEIN RAP-1B
P02759	Pyridoxal-5-phosphate biosynthesis	P03062	1-Deoxyxylulose-5-phosphate synthase	THEMA|EnsemblGenome=TM_1770|UniProtKB=Q9X291	1-deoxy-D-xylulose-5-phosphate synthase	ISS			PTHR43322:SF5	1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE 1-RELATED
P05726	2-arachidonoylglycerol biosynthesis	P05735	PLA1	MOUSE|MGI=MGI=1934677|UniProtKB=Q8VI78	Phospholipase A1 member A	IC			PTHR11610:SF111	PHOSPHOLIPASE A1 MEMBER A
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01167	Ets	MACMU|Ensembl=ENSMMUG00000004984|UniProtKB=F7ATZ3	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF10	ETS-RELATED TRANSCRIPTION FACTOR ELF-2
P00029	Huntington disease	P00780	Microtubule	TAKRU|Ensembl=ENSTRUG00000012143|UniProtKB=H2U1C0	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00060	Ubiquitin proteasome pathway	P01494	19S proteasome	PHYPA|Gene=PHYPADRAFT_190505|UniProtKB=A9T0R6	Predicted protein	ISS			PTHR23073:SF8	26S PROTEASE REGULATORY SUBUNIT 6B
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	10747026	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05730	Endogenous cannabinoid signaling	P05746	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MOUSE|MGI=MGI=87891|UniProtKB=Q9ERK7	Neuronal acetylcholine receptor subunit beta-2	IC	22213672	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05754	Ggamma	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00034	Integrin signalling pathway	P00944	Actin	BOVIN|Gene=ACTB|UniProtKB=P60712	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	DROME|FlyBase=FBgn0003189|UniProtKB=P05990	CAD protein	ISS			PTHR11405:SF5	CAD PROTEIN
P00057	Wnt signaling pathway	P01438	PP2A	DANRE|ZFIN=ZDB-GENE-030904-7|UniProtKB=Q8AXX6	Ppp2r5e2 protein	ISS	10092233	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	P01435	SWI/SNF	MACMU|Ensembl=ENSMMUG00000017255|UniProtKB=F7H9L1	Uncharacterized protein	ISS	11532957	PubMed	PTHR10799:SF812	LYMPHOID-SPECIFIC HELICASE
P00057	Wnt signaling pathway	P01452	NFAT	HUMAN|HGNC=7778|UniProtKB=Q14934	Nuclear factor of activated T-cells, cytoplasmic 4	IDA	9133421	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P05731	GABA-B receptor II signaling	P05755	Gbeta	RAT|RGD=69319|UniProtKB=P54313	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00006	Apoptosis signaling pathway	P00321	HSP70	SCHMA|EnsemblGenome=Smp_049550|UniProtKB=G4V910	Putative heat shock protein 70 (Hsp70)	ISS	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IDA	2837282	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	TAS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00029	Huntington disease	P00799	JNK-2	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00055	Transcription regulation by bZIP transcription factor	P01391	TFIIFalpha	DROME|FlyBase=FBgn0010282|UniProtKB=Q05913	General transcription factor IIF subunit 1	ISS			PTHR13011:SF0	GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	ANOGA|EnsemblGenome=AGAP001478|UniProtKB=Q7PXM3	AGAP001478-PA	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00057	Wnt signaling pathway	P01438	PP2A	CHICK|Ensembl=ENSGALG00000010273|UniProtKB=P48463	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	1662645	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05915	Opioid proenkephalin pathway	P05993	AC	RAT|RGD=619965|UniProtKB=P26769	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00018	EGF receptor signaling pathway	P00539	14-3-3	MOUSE|MGI=MGI=894689|UniProtKB=P62259	14-3-3 protein epsilon	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CANLF|Ensembl=ENSCAFG00000003333|UniProtKB=F1PWT6	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04569	Cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00050	Plasminogen activating cascade	P01252	MMP-1	PANTR|Ensembl=ENSPTRG00000023318|UniProtKB=H2Q4N3	Matrix metallopeptidase 1 (Interstitial collagenase)	ISS	3009463	PubMed	PTHR10201:SF151	INTERSTITIAL COLLAGENASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MACMU|Ensembl=ENSMMUG00000010392|UniProtKB=F7ASR8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00049	Parkinson disease	P01222	Ubc6	CHICK|Ensembl=ENSGALG00000001848|UniProtKB=E1BZ66	Uncharacterized protein	ISS	12859888	PubMed	PTHR43972:SF1	UBIQUITIN-CONJUGATING ENZYME E2 J2
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MACMU|Ensembl=ENSMMUG00000017431|UniProtKB=F7HPP3	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00024	Glycolysis	P00677	Hexokinase	MOUSE|MGI=MGI=1315197|UniProtKB=O08528	Hexokinase-2	RCA			PTHR19443:SF4	HEXOKINASE-2
P00059	p53 pathway	P01481	ATM/ATR	RAT|RGD=1593265|UniProtKB=D4ACL8	Ataxia telangiectasia mutated homolog (Human) (Mapped), isoform CRA_a	ISS			PTHR11139:SF72	SERINE-PROTEIN KINASE ATM
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT1G73670|UniProtKB=Q9C9U4	Mitogen-activated protein kinase 15	ISS	176948	OMIM	PTHR24055:SF246	MITOGEN-ACTIVATED PROTEIN KINASE 15-RELATED
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P06664	Gonadotropin-releasing hormone receptor pathway	P06838	CTNNB1	MOUSE|MGI=MGI=88276|UniProtKB=Q02248	Catenin beta-1	RCA	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00017	DNA replication	P00528	Primase	PANTR|Ensembl=ENSPTRG00000022987|UniProtKB=H2R0Q8	DNA primase	ISS	10441007	PubMed	PTHR10536:SF0	DNA PRIMASE SMALL SUBUNIT
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IDA	176892	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00048	PI3 kinase pathway	P01192	p110	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00277	Bi1	ANOGA|EnsemblGenome=AGAP005775|UniProtKB=Q7Q6L7	AGAP005775-PA	ISS			PTHR23291:SF34	BAX INHIBITOR 1
P00052	TGF-beta signaling pathway	P01284	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=2652894|UniProtKB=Q80Y86	Mitogen-activated protein kinase 15	ISS	10851062	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00021	FGF signaling pathway	P00643	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05913	Enkephalin release	P05974	G-Protein (i)	ORNAN|Ensembl=ENSOANG00000003489|UniProtKB=F7FSE3	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00029	Huntington disease	G01533	Bax	MOUSE|MGI=MGI=99702|UniProtKB=Q07813	Apoptosis regulator BAX	TAS	11099028	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	TAS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00038	JAK/STAT signaling pathway	P01027	STAT	HUMAN|HGNC=11362|UniProtKB=P42224	Signal transducer and activator of transcription 1-alpha/beta	ISS	10207096	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00036	Interleukin signaling pathway	P00972	MNK1/2	MACMU|Ensembl=ENSMMUG00000011265|UniProtKB=F6WP09	Uncharacterized protein	ISS	11463832	PubMed	PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	DROME|FlyBase=FBgn0002413|UniProtKB=O76324	Discs overgrown protein kinase	IDA	14712927	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00759	PDEalphabeta	BOVIN|Gene=PDE6A|UniProtKB=P11541	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	ISS	7493036	PubMed	PTHR11347:SF115	ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01452	NFAT	PANTR|Ensembl=ENSPTRG00000013628|UniProtKB=H2R4F5	Uncharacterized protein	ISS	12787506	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00012	Cadherin signaling pathway	P00470	F-actin	MACMU|Ensembl=ENSMMUG00000009341|UniProtKB=F6UA54	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00012	Cadherin signaling pathway	P00470	F-actin	CANLF|Ensembl=ENSCAFG00000003197|UniProtKB=E2QXY7	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	IC	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01443	Phospholipase C	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04375	5HT3 type receptor mediated signaling pathway	P04425	K+ channel	HUMAN|HGNC=6278|UniProtKB=O14649	Potassium channel subfamily K member 3	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P02734	Chorismate biosynthesis	P02873	Shikimate dehydrogenase	THEMA|EnsemblGenome=TM_0346|UniProtKB=Q9WYI1	Shikimate dehydrogenase (NADP(+))	ISS			PTHR21089:SF1	BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE/SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05924	AT1-R	BOVIN|Ensembl=ENSBTAG00000045633|UniProtKB=P25104	Type-1 angiotensin II receptor	RCA			PTHR24228:SF11	TYPE-1 ANGIOTENSIN II RECEPTOR
P00048	PI3 kinase pathway	P01188	Gbetagamma	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	DANRE|ZFIN=ZDB-GENE-031110-4|UniProtKB=Q6NW90	Tubulin, beta 5	ISS	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CAEEL|WormBase=WBGene00001188|UniProtKB=G5EG05	Uncharacterized protein	TAS	8717036	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	CAEEL|WormBase=WBGene00004860|UniProtKB=Q09488	Serine/threonine-protein kinase sma-6	TAS	11252892	PubMed	PTHR23255:SF68	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P02730	Asparagine and aspartate biosynthesis	P02853	Asparagine synthetase	HALSA|EnsemblGenome=VNG_0867G|UniProtKB=Q9HR47	Asparagine synthetase	ISS			PTHR11772:SF2	ASPARAGINE SYNTHETASE
P00036	Interleukin signaling pathway	P00964	p90RSK	HUMAN|HGNC=10430|UniProtKB=Q15418	Ribosomal protein S6 kinase alpha-1	ISS	2779569	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00035	Interferon-gamma signaling pathway	P00956	SOCS	BOVIN|Ensembl=ENSBTAG00000008535|UniProtKB=E1BIS1	Uncharacterized protein	ISS	12645661	PubMed	PTHR45052:SF1	SUPPRESSOR OF CYTOKINE SIGNALING 7
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=19218|UniProtKB=Q86YW0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1	ISS	7822322	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	LEIMA|EnsemblGenome=LmjF.18.1080|UniProtKB=Q27687	Protein kinase A catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00049	Parkinson disease	P01238	14-3-3	MOUSE|MGI=MGI=108109|UniProtKB=P61982	14-3-3 protein gamma	ISS	10407019	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	12657601	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00053	T cell activation	P01315	Calcineurin	MOUSE|MGI=MGI=107163|UniProtKB=P48453	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	ISS	12091710	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00557	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P00048	PI3 kinase pathway	P01192	p110	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2744|UniProtKB=P31422	Metabotropic glutamate receptor 3	IDA	20012997	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00059	p53 pathway	P04609	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CAEEL|WormBase=WBGene00001187|UniProtKB=Q8MQA1	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MOUSE|MGI=MGI=99675|UniProtKB=Q8VHH7	Adenylate cyclase type 3	ISS	12623444	PubMed	PTHR11920:SF291	ADENYLATE CYCLASE TYPE 3
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MONDO|Ensembl=ENSMODG00000001430|UniProtKB=F7BCI5	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00025	Hedgehog signaling pathway	P00692	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	P00558	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IGI	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	PANTR|Gene=GOT1|UniProtKB=A5A6K8	Aspartate aminotransferase, cytoplasmic	ISS			PTHR11879:SF3	ASPARTATE AMINOTRANSFERASE, CYTOPLASMIC
P00057	Wnt signaling pathway	P01438	PP2A	MACMU|Ensembl=ENSMMUG00000013047|UniProtKB=F7H808	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IC	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00807	Actin	PUCGT|EnsemblGenome=PGTG_05488|UniProtKB=E3K4I1	Actin	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g242065|UniProtKB=A7S0V7	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1693|UniProtKB=Q6P967	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00054	Toll receptor signaling pathway	P01345	IKKalpha	BOVIN|Ensembl=ENSBTAG00000007591|UniProtKB=Q95KV1	Inhibitor of nuclear factor kappa-B kinase subunit alpha	ISS	9346484	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00047	PDGF signaling pathway	P01162	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00786	ARF	RAT|RGD=621326|UniProtKB=P61212	ADP-ribosylation factor-like protein 1	IPI	11752622	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P00057	Wnt signaling pathway	P01440	Cadherin	XENTR|Xenbase=XB-GENE-482277|UniProtKB=F6QAX3	Uncharacterized protein	ISS	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P00057	Wnt signaling pathway	P01443	Phospholipase C	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CHICK|Ensembl=ENSGALG00000014620|UniProtKB=F1N8P3	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ANOGA|EnsemblGenome=AGAP001676|UniProtKB=Q7PXZ8	AGAP001676-PA	IC	10974003	PubMed	PTHR11937:SF368	ACTIN, INDIRECT FLIGHT MUSCLE
P00021	FGF signaling pathway	P00627	ERK1-2	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	12471242	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00011	Blood coagulation	P00414	Thrombin	MOUSE|MGI=MGI=88380|UniProtKB=P19221	Prothrombin	ISS	12621076	gi	PTHR24254:SF10	PROTHROMBIN
P00053	T cell activation	P01332	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=621025|UniProtKB=Q62711	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	TAS			PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	XENTR|Xenbase=XB-GENE-478859|UniProtKB=F6Z9Y1	Uncharacterized protein	ISS	12356903	PubMed	PTHR11514:SF3	N-MYC PROTO-ONCOGENE PROTEIN
P00005	Angiogenesis	P00223	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04396	Vitamin D metabolism and pathway	P04605	P450 reductase	CAEEL|WormBase=WBGene00001262|UniProtKB=Q09590	NADPH--cytochrome P450 reductase	TAS	2513880	PubMed	PTHR19384:SF17	NADPH--CYTOCHROME P450 REDUCTASE
P00018	EGF receptor signaling pathway	P00552	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IGI	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P00019	Endothelin signaling pathway	P00591	PLCbeta	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05730	Endogenous cannabinoid signaling	P05743	CB1	MACMU|Gene=CNR1|UniProtKB=Q71SP5	Cannabinoid receptor 1	ISS	2165569	PubMed	PTHR22750:SF47	CANNABINOID RECEPTOR 1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00036	Interleukin signaling pathway	P00976	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	P00561	STAT	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	ISS	14984365	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00057	Wnt signaling pathway	P01444	Wnt	BOVIN|Ensembl=ENSBTAG00000014291|UniProtKB=A6H6X8	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00018	EGF receptor signaling pathway	P00539	14-3-3	ARATH|TAIR=AT2G42590|UniProtKB=Q96299	14-3-3-like protein GF14 mu	ISS	10407019	PubMed	PTHR18860:SF31	14-3-3-LIKE PROTEIN GF14 MU
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00203	Erk	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	TAS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02754	Methylcitrate cycle	P03028	Aconitase	HUMAN|HGNC=6115|UniProtKB=P48200	Iron-responsive element-binding protein 2	ISS			PTHR11670:SF31	IRON-RESPONSIVE ELEMENT-BINDING PROTEIN 2
P00020	FAS signaling pathway	P00615	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05731	GABA-B receptor II signaling	P05753	Ca channel	HUMAN|HGNC=1389|UniProtKB=Q00975	Voltage-dependent N-type calcium channel subunit alpha-1B	TAS	14507926	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	RCA	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00539	14-3-3	PANTR|Ensembl=ENSPTRG00000013529|UniProtKB=H2R8X6	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000029807|UniProtKB=F6UY56	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF54	PROTOCADHERIN BETA-10
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	CANLF|Ensembl=ENSCAFG00000010871|UniProtKB=F1PXA0	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01408	Akt/PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	89107990	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04398	p53 pathway feedback loops 2	P04650	WIP-1	PANTR|Ensembl=ENSPTRG00000009487|UniProtKB=H2RBB5	Uncharacterized protein	ISS			PTHR13832:SF359	PROTEIN PHOSPHATASE 1D
P05916	Opioid prodynorphin pathway	P06002	G-protein	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DICDI|dictyBase=DDB_G0279413|UniProtKB=P05987	cAMP-dependent protein kinase regulatory subunit	IC	2372396	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9062|UniProtKB=Q9BRC7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	TAS			PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00045	Notch signaling pathway	P01108	Nicastrin	CAEEL|WormBase=WBGene00000148|UniProtKB=Q23316	Nicastrin	TAS	10993067	PubMed	PTHR21092:SF0	NICASTRIN
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	PANTR|Ensembl=ENSPTRG00000022187|UniProtKB=Q7YQL4	Serine/threonine-protein kinase PAK 3	ISS	11259591	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00021	FGF signaling pathway	P00645	Rac	MACMU|Ensembl=ENSMMUG00000021075|UniProtKB=F7GY91	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00007	Axon guidance mediated by semaphorins	P00340	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	15470041	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=19218|UniProtKB=Q86YW0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1	ISS	15611108	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P00047	PDGF signaling pathway	P01173	STAT	BOVIN|Gene=STAT3|UniProtKB=P61635	Signal transducer and activator of transcription 3	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04395	Vasopressin synthesis	P04593	Glycopeptide	MOUSE|MGI=MGI=97453|UniProtKB=P35454	Oxytocin-neurophysin 1	IC	6717565	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00047	PDGF signaling pathway	P01153	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05734	Synaptic vesicle trafficking	P05774	NSF	PANTR|Ensembl=ENSPTRG00000009320|UniProtKB=H2QD95	N-ethylmaleimide-sensitive factor	ISS	601633	OMIM	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00005	Angiogenesis	P00203	Erk	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DROME|FlyBase=FBgn0000046|UniProtKB=P10981	Actin-87E	ISS	11889126	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	HUMAN|HGNC=129|UniProtKB=P68133	Actin, alpha skeletal muscle	IC	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00029	Huntington disease	P00777	CBP	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	IDA	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF31	SUBFAMILY NOT NAMED
P00053	T cell activation	P01331	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	ANOGA|EnsemblGenome=AGAP005913|UniProtKB=Q7Q6D2	AGAP005913-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00029	Huntington disease	P00802	PACSIN-1	RAT|RGD=3247|UniProtKB=Q9Z0W5	Protein kinase C and casein kinase substrate in neurons protein 1	IDA	12354780	PubMed	PTHR23065:SF16	PROTEIN KINASE C AND CASEIN KINASE SUBSTRATE IN NEURONS PROTEIN 1
P00049	Parkinson disease	P01242	Casein kinase I	CHICK|Ensembl=ENSGALG00000002719|UniProtKB=E1BVW0	Uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00036	Interleukin signaling pathway	P00990	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	TAS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	BOVIN|Ensembl=ENSBTAG00000000256|UniProtKB=F1MH28	Uncharacterized protein	ISS	9783586	PubMed	PTHR10814:SF23	TRANSDUCIN-LIKE ENHANCER PROTEIN 1
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P02743	Formyltetrahydroformate biosynthesis	P02953	Cobalamin dependent homocysteine transmethylase	DROME|FlyBase=FBgn0032727|UniProtKB=Q9VJ31	CG10623 protein	ISS			PTHR21091:SF123	FI01821P
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	XENTR|Xenbase=XB-GENE-957124|UniProtKB=F7BDN8	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P02746	Heme biosynthesis	P02979	porphobilinogen synthase	SULSO|EnsemblGenome=SSO0181|UniProtKB=Q980U6	Delta-aminolevulinic acid dehydratase	ISS			PTHR11458:SF0	DELTA-AMINOLEVULINIC ACID DEHYDRATASE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MACMU|Ensembl=ENSMMUG00000010266|UniProtKB=F6PV18	Uncharacterized protein	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	MONDO|Ensembl=ENSMODG00000006787|UniProtKB=F6PH60	Glutamine synthetase	ISS			PTHR20852:SF45	GLUTAMINE SYNTHETASE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	10395542	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02738	De novo purine biosynthesis	P02894	IMP cyclohydrolase	DEIRA|EnsemblGenome=DR_0868|UniProtKB=Q9RW01	Bifunctional purine biosynthesis protein PurH	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	CHICK|Gene=CHRM4|UniProtKB=P17200	Muscarinic acetylcholine receptor M4	ISS	91373358	PubMed	PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00019	Endothelin signaling pathway	P00586	Gq	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00005	Angiogenesis	P00237	FRP	BOVIN|Ensembl=ENSBTAG00000035084|UniProtKB=F1MLG5	Uncharacterized protein	ISS	12549854	PubMed	PTHR11309:SF22	FRIZZLED-3
P00034	Integrin signalling pathway	P00925	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IDA	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00052	TGF-beta signaling pathway	P01284	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04567	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00005	Angiogenesis	P00203	Erk	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00224	PDGF	HUMAN|HGNC=8800|UniProtKB=P01127	Platelet-derived growth factor subunit B	ISS			PTHR11633:SF2	PLATELET-DERIVED GROWTH FACTOR SUBUNIT B
P06214	GBB signaling pathway	P06303	LACK	DROME|FlyBase=FBgn0029006|UniProtKB=Q9V853	E3 ubiquitin-protein ligase Smurf1	IEA	http://flybase.org/reports/FBgn0029006.html	Website	PTHR11254:SF395	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	IDA	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00010	B cell activation	P00402	Jnk	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02748	Isoleucine biosynthesis	P02995	Threonine dehydratase	YEAST|SGD=S000001701|UniProtKB=P36007	Threo-3-hydroxyaspartate ammonia-lyase	ISS			PTHR43050:SF1	SERINE RACEMASE
P04398	p53 pathway feedback loops 2	P04665	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000008719|UniProtKB=F1MZX0	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00010	B cell activation	P00381	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00021	FGF signaling pathway	P00635	FRS2	XENTR|Xenbase=XB-GENE-479760|UniProtKB=B5DE89	Frs2 protein	ISS	21384985	PubMed	PTHR21258:SF40	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	HUMAN|HGNC=4580|UniProtKB=Q13002	Glutamate receptor ionotropic, kainate 2	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00052	TGF-beta signaling pathway	P01286	TGFbeta	RAT|RGD=70491|UniProtKB=Q07257	Transforming growth factor beta-2	TAS	9759503	PubMed	PTHR11848:SF141	TRANSFORMING GROWTH FACTOR BETA-2
P02785	Valine biosynthesis	P03216	Acetolactate synthase	PSEAE|EnsemblGenome=PA2035|UniProtKB=Q9I280	Probable decarboxylase	ISS			PTHR18968:SF120	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00018	EGF receptor signaling pathway	P00539	14-3-3	CRYNJ|EnsemblGenome=CNL03930|UniProtKB=Q5K8Z6	14-3-3 protein, putative	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00019	Endothelin signaling pathway	P00588	ET1-4	MOUSE|MGI=MGI=95284|UniProtKB=P22389	Endothelin-2	ISS			PTHR13874:SF9	ENDOTHELIN-2
P00053	T cell activation	P01309	fos	BOVIN|Ensembl=ENSBTAG00000004322|UniProtKB=O77628	Proto-oncogene c-Fos	TAS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	TAS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00056	VEGF signaling pathway	P01411	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P04393	Ras Pathway	P04578	Rho	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	ISS	10556059	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05730	Endogenous cannabinoid signaling	P05748	mGluR	HUMAN|HGNC=4597|UniProtKB=P41594	Metabotropic glutamate receptor 5	ISS	12488551	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	RAT|RGD=2738|UniProtKB=Q00960	Glutamate receptor ionotropic, NMDA 2B	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00005	Angiogenesis	P00222	VEGFR-2	CHICK|Ensembl=ENSGALG00000005802|UniProtKB=F1N871	Uncharacterized protein	ISS			PTHR24416:SF49	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00830	Lipoxygenase	BOVIN|Ensembl=ENSBTAG00000013201|UniProtKB=Q148F2	Arachidonate 5-lipoxygenase-activating protein	ISS	11937571	PubMed	PTHR10250:SF2	ARACHIDONATE 5-LIPOXYGENASE-ACTIVATING PROTEIN
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	STRPU|EnsemblGenome=SPU_025182|UniProtKB=W4ZAK5	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00021	FGF signaling pathway	P00623	FGF	DANRE|ZFIN=ZDB-GENE-990415-72|UniProtKB=O57341	Fibroblast growth factor 8	IGI	14651935	PubMed	PTHR11486:SF3	FIBROBLAST GROWTH FACTOR 8
P00010	B cell activation	P00384	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04395	Vasopressin synthesis	P04589	Signal Peptidase	BOVIN|Ensembl=ENSBTAG00000011239|UniProtKB=P67810	Signal peptidase complex catalytic subunit SEC11A	ISS	2674115	PubMed	PTHR10806:SF8	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11A-RELATED
P00059	p53 pathway	G01581	BAX	XENTR|Xenbase=XB-GENE-486067|UniProtKB=Q6P4Y4	BCL2-associated X protein	ISS	8358790	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P02740	De novo pyrimidine ribonucleotides biosythesis	P02922	Orotate phosphoribosyltransferase	METAC|EnsemblGenome=MA_3307|UniProtKB=P58859	Orotate phosphoribosyltransferase	ISS			PTHR19278:SF49	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00049	Parkinson disease	P01236	Casein kinase II	DICDI|dictyBase=DDB_G0276885|UniProtKB=Q02720	Casein kinase II subunit alpha	IDA	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00045	Notch signaling pathway	G01541	E(spl)-C genes	HUMAN|HGNC=4882|UniProtKB=Q9NQ87	Hairy/enhancer-of-split related with YRPW motif-like protein	TAS	10860664	PubMed	PTHR10985:SF79	HAIRY/ENHANCER-OF-SPLIT RELATED WITH YRPW MOTIF-LIKE PROTEIN
P00006	Apoptosis signaling pathway	P00269	MAPK	ORYSJ|EnsemblGenome=OS02G0148100|UniProtKB=Q6Z437	Mitogen-activated protein kinase 3	ISS	11707292	PubMed	PTHR24055:SF216	SUBFAMILY NOT NAMED
P00053	T cell activation	P01295	vav	CANLF|Ensembl=ENSCAFG00000019951|UniProtKB=F1PET4	Uncharacterized protein	ISS	14623913	PubMed	PTHR22826:SF97	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=3036262|UniProtKB=Q3USB7	Inactive phospholipase C-like protein 1	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P00012	Cadherin signaling pathway	P00474	Wnt	RAT|RGD=1597195|UniProtKB=D4A9J2	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IGI	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04398	p53 pathway feedback loops 2	P04661	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00005	Angiogenesis	P00211	GSK3beta	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00047	PDGF signaling pathway	P01143	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00375	Calmodulin	BOVIN|Ensembl=ENSBTAG00000014583|UniProtKB=P62157	Calmodulin	ISS	7514101	PubMed	PTHR23050:SF335	CALMODULIN, STRIATED MUSCLE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	YEAST|SGD=S000003272|UniProtKB=P14681	Mitogen-activated protein kinase KSS1	ISS			PTHR24055:SF338	MITOGEN-ACTIVATED PROTEIN KINASE KSS1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02736	Coenzyme A biosynthesis	P02885	Pantothenate kinase	XENTR|Xenbase=XB-GENE-991062|UniProtKB=A9ULG9	LOC100135204 protein	ISS			PTHR12280:SF21	PANTOTHENATE KINASE 3
P00057	Wnt signaling pathway	P01438	PP2A	CANLF|Ensembl=ENSCAFG00000001753|UniProtKB=F1P714	Uncharacterized protein	ISS	96161994	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00048	PI3 kinase pathway	P01177	P110ACT	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	TAS	12846562	PubMed	PTHR10202:SF13	PRESENILIN-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2520|UniProtKB=P61169	D(2) dopamine receptor	IDA	2137198	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00006	Apoptosis signaling pathway	P00269	MAPK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01161	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IDA	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	TAS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00056	VEGF signaling pathway	P01412	HSP27	RAT|RGD=70914|UniProtKB=O35878	Heat shock protein beta-2	ISS			PTHR11527:SF163	HEAT SHOCK PROTEIN BETA-2
P00021	FGF signaling pathway	P00632	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04397	p53 pathway by glucose deprivation	P04641	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00778	NMDA receptor	CHICK|Ensembl=ENSGALG00000008898|UniProtKB=F1P2J9	Uncharacterized protein	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04398	p53 pathway feedback loops 2	P04657	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01177	P110ACT	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00025	Hedgehog signaling pathway	P00699	Su(fu)	PANTR|Ensembl=ENSPTRG00000002895|UniProtKB=H2Q2H8	Suppressor of fused homolog	ISS	10920228	PubMed	PTHR10928:SF2	SUPPRESSOR OF FUSED HOMOLOG
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	HUMAN|HGNC=5960|UniProtKB=O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00029	Huntington disease	P00790	beta-Tubulin	DANRE|ZFIN=ZDB-GENE-050522-384|UniProtKB=F1QKY8	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00005	Angiogenesis	P00182	p38MAPK	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=98960|UniProtKB=P22727	Protein Wnt-6	TAS	8717036	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P00048	PI3 kinase pathway	P01179	PKB	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01395	TFIIE	NEUCR|EnsemblGenome=EFNCRG00000004082|UniProtKB=Q1K7U9	Transcription factor TFIIE complex alpha subunit	ISS			PTHR13097:SF7	NOVEL PROTEIN SIMILAR TO VERTEBRATE GENERAL TRANSCRIPTION FACTOR IIE POLYPEPTIDE 1 ALPHA 56KDA  GTF2E1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	LEPIN|EnsemblGenome=LA_1929|UniProtKB=Q8CXT1	CAP family transcription factor	IC	88234494	PubMed	PTHR45452:SF1	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00629	PP2A	NEUCR|EnsemblGenome=EFNCRG00000002521|UniProtKB=Q1K5B6	Serine/threonine-protein phosphatase	ISS			PTHR11668:SF24	SERINE/THREONINE-PROTEIN PHOSPHATASE 6 CATALYTIC SUBUNIT
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MOUSE|MGI=MGI=1351342|UniProtKB=Q3UVX5	Metabotropic glutamate receptor 5	ISS	12351712	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00059	p53 pathway	P04633	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00965	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	MACMU|Ensembl=ENSMMUG00000001338|UniProtKB=F6QFI6	Uncharacterized protein	ISS			PTHR11482:SF7	ANTIZYME INHIBITOR 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	RAT|RGD=621440|UniProtKB=Q63511	G protein-activated inward rectifier potassium channel 3	IDA	12374786	PubMed	PTHR11767:SF17	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 3
P00012	Cadherin signaling pathway	P00462	Casein kinase II	MACMU|Ensembl=ENSMMUG00000031224|UniProtKB=F7CKT2	Uncharacterized protein	ISS	10617630	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	RAT|RGD=1308867|UniProtKB=A1L108	Actin-related protein 2/3 complex subunit 5-like protein	ISS			PTHR12644:SF2	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5-LIKE PROTEIN
P00013	Cell cycle	P00478	Pre-replication Complex	HUMAN|HGNC=10291|UniProtKB=P35244	Replication protein A 14 kDa subunit	ISS	8454588	PubMed	PTHR15114:SF1	REPLICATION PROTEIN A 14 KDA SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01284	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00049	Parkinson disease	P01219	SAPK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12960248	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00018	EGF receptor signaling pathway	P00561	STAT	MACMU|Ensembl=ENSMMUG00000017527|UniProtKB=F6UMM2	Signal transducer and activator of transcription	ISS	94367369	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=1951|UniProtKB=P08172	Muscarinic acetylcholine receptor M2	IDA	10069496	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04392	P53 pathway feedback loops 1	P04536	Mdm2	BOVIN|Ensembl=ENSBTAG00000010422|UniProtKB=F1MYE6	Uncharacterized protein	ISS	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	HUMAN|HGNC=11640|UniProtKB=Q9HCS4	Transcription factor 7-like 1	TAS	9118222	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00049	Parkinson disease	P01219	SAPK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CHICK|Gene=ACTA2|UniProtKB=P08023	Actin, aortic smooth muscle	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	RAT|RGD=2736|UniProtKB=P35439	Glutamate receptor ionotropic, NMDA 1	IC	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00056	VEGF signaling pathway	P01408	Akt/PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00193	SOS-1	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS			PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	DANRE|ZFIN=ZDB-GENE-980526-526|UniProtKB=P24257	Protein Wnt-1	TAS	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00010	B cell activation	P00386	Calcineurin	XENTR|Xenbase=XB-GENE-952299|UniProtKB=B0BLZ8	Serine/threonine-protein phosphatase	ISS	12015605	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00474	Wnt	RAT|RGD=1307015|UniProtKB=D3ZRW5	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00018	EGF receptor signaling pathway	P00560	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CAEBR|Gene=CBG14305|UniProtKB=A8XJQ6	cAMP-dependent protein kinase, catalytic subunit-like	ISS	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00024	Glycolysis	P00678	Enolase	ORNAN|Ensembl=ENSOANG00000013484|UniProtKB=F7FAQ8	Uncharacterized protein (Fragment)	ISS	89079778	PubMed	PTHR11902:SF12	ALPHA-ENOLASE
P04393	Ras Pathway	P04541	p90RSK	MACMU|Ensembl=ENSMMUG00000002134|UniProtKB=F6UNV6	Ribosomal protein S6 kinase	ISS	2779569	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00045	Notch signaling pathway	P01110	Presenilin	CAEEL|WormBase=WBGene00004769|UniProtKB=P52166	Presenilin sel-12	IGI	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00045	Notch signaling pathway	P01110	Presenilin	CAEEL|WormBase=WBGene00001985|UniProtKB=O02100	Presenilin hop-1	IGI	12834808	PubMed	PTHR10202:SF14	PRESENILIN HOP-1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	CANLF|Gene=VWF|UniProtKB=Q28295	von Willebrand factor	TAS	11583304	PubMed	PTHR11339:SF361	VON WILLEBRAND FACTOR-RELATED
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	PANTR|Ensembl=ENSPTRG00000004326|UniProtKB=H2Q4V0	Uncharacterized protein	ISS			PTHR44107:SF3	DOWN SYNDROME CELL ADHESION MOLECULE-LIKE PROTEIN 1
P00057	Wnt signaling pathway	P01437	TCF	HUMAN|HGNC=6551|UniProtKB=Q9UJU2	Lymphoid enhancer-binding factor 1	IDA	9039917	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00054	Toll receptor signaling pathway	P01345	IKKalpha	MOUSE|MGI=MGI=99484|UniProtKB=Q60680	Inhibitor of nuclear factor kappa-B kinase subunit alpha	ISS	12813046	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=619748|UniProtKB=P55281	Cadherin-17	IDA	8120095	PubMed	PTHR44603:SF2	CADHERIN-17
P00008	Axon guidance mediated by Slit/Robo	P00342	Slit	BOVIN|Ensembl=ENSBTAG00000043991|UniProtKB=E1BP10	Uncharacterized protein	ISS	10432110	PubMed	PTHR24373:SF39	SLIT HOMOLOG 1 PROTEIN
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00005	Angiogenesis	P00219	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P06215	MYO signaling pathway	P06315	myoglianin full length	DROME|FlyBase=FBgn0026199|UniProtKB=Q9V4F4	LD29161p	IDA	16098524	PubMed	PTHR11848:SF176	LD29161P
P04393	Ras Pathway	P04565	MKK4/7	CANLF|Ensembl=ENSCAFG00000017851|UniProtKB=F1PBB6	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00021	FGF signaling pathway	P00623	FGF	CANLF|Ensembl=ENSCAFG00000032695|UniProtKB=J9NVD5	Fibroblast growth factor	ISS	8663172	PubMed	PTHR11486:SF21	FIBROBLAST GROWTH FACTOR 10
P00018	EGF receptor signaling pathway	P00557	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00056	VEGF signaling pathway	P01409	cPLA2	CANLF|Ensembl=ENSCAFG00000013778|UniProtKB=F6UQ33	Phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	TAKRU|Ensembl=ENSTRUG00000016241|UniProtKB=H2UX35	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF305	PROTEIN KINASE C
P00054	Toll receptor signaling pathway	P01345	IKKalpha	PANTR|Ensembl=ENSPTRG00000033948|UniProtKB=H2RBD4	Conserved helix-loop-helix ubiquitous kinase	ISS	12235208	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00029	Huntington disease	G01531	BDNF	ORNAN|Ensembl=ENSOANG00000013030|UniProtKB=O02795	Brain-derived neurotrophic factor (Fragment)	ISS	11724916	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=109356|UniProtKB=O09044	Synaptosomal-associated protein 23	IC	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	IDA	10514528	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04398	p53 pathway feedback loops 2	P04668	p53	MACMU|Ensembl=ENSMMUG00000008639|UniProtKB=P56424	Cellular tumor antigen p53	TAS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	PANTR|Ensembl=ENSPTRG00000029110|UniProtKB=H2R6C6	Jun B proto-oncogene	ISS	10664585	PubMed	PTHR11462:SF37	TRANSCRIPTION FACTOR JUN-B
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00981	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04559	Rac	CHICK|Ensembl=ENSGALG00000007130|UniProtKB=F1N8D9	Uncharacterized protein	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00048	PI3 kinase pathway	P01199	Galpha	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	RAT|RGD=2090|UniProtKB=P00884	Fructose-bisphosphate aldolase B	ISS	8086469	PubMed	PTHR11627:SF2	FRUCTOSE-BISPHOSPHATE ALDOLASE B
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05915	Opioid proenkephalin pathway	P05994	G-protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05918	p38 MAPK pathway	P06022	eEF2K	MACMU|Ensembl=ENSMMUG00000017725|UniProtKB=F7F8P2	Uncharacterized protein	ISS	11500363	PubMed	PTHR14187:SF56	EUKARYOTIC ELONGATION FACTOR 2 KINASE
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	RCA	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00466	EGFR	BOVIN|Ensembl=ENSBTAG00000021798|UniProtKB=F1MCQ7	Receptor protein-tyrosine kinase	ISS	2575867	gi	PTHR24416:SF137	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	BRAFL|Gene=BRAFLDRAFT_123893|UniProtKB=C3XQF4	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00053	T cell activation	P01324	rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	TAS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IDA	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	ARATH|TAIR=AT1G55970|UniProtKB=Q9LG11	Histone acetyltransferase HAC4	ISS	8413673	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00035	Interferon-gamma signaling pathway	P00960	PTP	DANRE|ZFIN=ZDB-GENE-030131-5911|UniProtKB=F1QZU5	Tyrosine-protein phosphatase non-receptor type	ISS	95163101	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_58093|UniProtKB=C3Z4K3	Putative uncharacterized protein	IDA	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	MONDO|Ensembl=ENSMODG00000015970|UniProtKB=F7FD05	Uncharacterized protein	ISS	1354612	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MOUSE|MGI=MGI=99841|UniProtKB=P32304	5-hydroxytryptamine receptor 7	IDA	12181435	PubMed	PTHR24247:SF116	5-HYDROXYTRYPTAMINE RECEPTOR 7
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	CAEEL|WormBase=WBGene00003774|UniProtKB=G5EGQ9	NMDA class glutamate Receptor	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00018	EGF receptor signaling pathway	P00562	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04393	Ras Pathway	P04567	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00311	GCKR	MONDO|Ensembl=ENSMODG00000009097|UniProtKB=F7FCJ3	Mitogen-activated protein kinase kinase kinase kinase	ISS			PTHR24361:SF205	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ORNAN|Ensembl=ENSOANG00000013961|UniProtKB=F6VPY1	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00551	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=12779|UniProtKB=O14905	Protein Wnt-9b	TAS	11266476	PubMed	PTHR12027:SF84	PROTEIN WNT-9B
P04397	p53 pathway by glucose deprivation	P04641	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00056	VEGF signaling pathway	P01414	PLC-gamma	CAEEL|WormBase=WBGene00004038|UniProtKB=Q22070	Phosphoinositide phospholipase C	ISS			PTHR10336:SF91	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	RAT|RGD=1307994|UniProtKB=B6RK61	Myosin heavy chain 7B	ISS	10938134	PubMed	PTHR13140:SF358	MYOSIN-7B
P02726	Aminobutyrate degradation	P02824	Succinate semi-aldehyde dehydrogenase	SCHPO|PomBase=SPAC139.05|UniProtKB=Q9UTM8	Putative succinate-semialdehyde dehydrogenase C139.05 [NADP(+)]	ISS	12891648	PubMed	PTHR43353:SF5	SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CHICK|Ensembl=ENSGALG00000007447|UniProtKB=P09207	Tubulin beta-6 chain	ISS	9454836	PubMed	PTHR11588:SF112	TUBULIN BETA-1 CHAIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	SCHPO|PomBase=SPAC6G9.11|UniProtKB=Q92356	Synaptobrevin homolog 1	ISS			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	XENTR|Xenbase=XB-GENE-999257|UniProtKB=F7CEX4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF319	ADENYLATE CYCLASE TYPE 9
P00029	Huntington disease	P00798	Clathrin	BOVIN|Ensembl=ENSBTAG00000010740|UniProtKB=P04975	Clathrin light chain B	ISS	9388255	PubMed	PTHR10639:SF2	CLATHRIN LIGHT CHAIN B
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00368	vav	HUMAN|HGNC=12657|UniProtKB=P15498	Proto-oncogene vav	IGI	10661401	PubMed	PTHR22826:SF112	PROTO-ONCOGENE VAV
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00796	Kainate receptor	PANTR|Ensembl=ENSPTRG00000000543|UniProtKB=H2PYN8	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8701|UniProtKB=Q9Y5H0	Protocadherin gamma-A3	IDA	8120095	PubMed	PTHR24028:SF232	PROTOCADHERIN GAMMA-A3
P00049	Parkinson disease	P01219	SAPK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	NAS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00005	Angiogenesis	P00256	PLC-gamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000022548|UniProtKB=F6Y9J9	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00012	Cadherin signaling pathway	P00474	Wnt	BRAFL|Gene=BRAFLDRAFT_118309|UniProtKB=C3YZ17	Protein Wnt	IDA	8717036	PubMed	PTHR12027:SF100	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Gene=OPRM1|UniProtKB=P79350	Mu-type opioid receptor	IDA	12093103	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00057	Wnt signaling pathway	P01431	LRP5/6	MONDO|Ensembl=ENSMODG00000018237|UniProtKB=F6PG65	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00045	Notch signaling pathway	P01099	Notch	MACMU|Ensembl=ENSMMUG00000018375|UniProtKB=F7H1D5	Neurogenic locus notch homolog protein 2 isoform 1 preproprotein	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	RCA			PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	MACMU|Ensembl=ENSMMUG00000014627|UniProtKB=F7GNE4	Catenin beta-1	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P00006	Apoptosis signaling pathway	P00260	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00060	Ubiquitin proteasome pathway	P01491	E2	MACMU|Ensembl=ENSMMUG00000006759|UniProtKB=F7HD05	Ubiquitin-conjugating enzyme E2 G2 isoform 1	ISS			PTHR24067:SF154	UBIQUITIN-CONJUGATING ENZYME E2 G2
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P06587	Nicotine pharmacodynamics pathway	P06614	TH	MACMU|Ensembl=ENSMMUG00000003912|UniProtKB=F6ZV38	Uncharacterized protein	ISS	191290	OMIM	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	TAS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01332	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=98956|UniProtKB=P27467	Protein Wnt-3a	IDA	11266476	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P00053	T cell activation	P01300	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=1930705|UniProtKB=P61264	Syntaxin-1B	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00047	PDGF signaling pathway	P01171	PLCgamma	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00047	PDGF signaling pathway	P01143	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04386	Histamine H2 receptor mediated signaling pathway	P04489	H2	RAT|RGD=2831|UniProtKB=P25102	Histamine H2 receptor	ISS	8817552	PubMed	PTHR43893:SF5	HISTAMINE H2 RECEPTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MACMU|Ensembl=ENSMMUG00000014227|UniProtKB=P56490	Muscarinic acetylcholine receptor M5	IDA	8100450	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00047	PDGF signaling pathway	P01154	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00551	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IGI	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	CAEEL|WormBase=WBGene00004960|UniProtKB=Q95PZ9	Serine/threonine-protein kinase spe-6	ISS	11437445	PubMed	PTHR11909:SF72	SERINE/THREONINE-PROTEIN KINASE SPE-6
P00010	B cell activation	P00385	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	NAS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00029	Huntington disease	P00805	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00001	Adrenaline and noradrenaline biosynthesis	P00067	MAO	MOUSE|MGI=MGI=96915|UniProtKB=Q64133	Amine oxidase [flavin-containing] A	ISS	8602220	PubMed	PTHR43563:SF3	AMINE OXIDASE  FLAVIN-CONTAINING  A
P02770	Pyridoxal phosphate salvage pathway	P03120	Pyridoxamine-5-phosphate oxidase	STRCO|EnsemblGenome=CAB95898|UniProtKB=Q9K3V7	Pyridoxine/pyridoxamine 5'-phosphate oxidase	ISS	12000953	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P04393	Ras Pathway	P04557	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	RAT|RGD=619965|UniProtKB=P26769	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00127	APP	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00153	gammacatenin	MOUSE|MGI=MGI=96650|UniProtKB=Q02257	Junction plakoglobin	ISS	9172160	PubMed	PTHR23315:SF12	JUNCTION PLAKOGLOBIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	RAT|RGD=2850|UniProtKB=Q62758	5-hydroxytryptamine receptor 4	IDA	12441358	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P04397	p53 pathway by glucose deprivation	P04641	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01192	p110	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00012	Cadherin signaling pathway	P00470	F-actin	DICPU|Gene=DICPUDRAFT_48914|UniProtKB=F0ZK40	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF154	ACTIN-17-RELATED
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00642	MEK1-2	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	ISS	19114921	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00045	Notch signaling pathway	P01099	Notch	HUMAN|HGNC=7881|UniProtKB=P46531	Neurogenic locus notch homolog protein 1	IGI	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00018	EGF receptor signaling pathway	P00547	PP2A	ORYSJ|EnsemblGenome=OS10G0410600|UniProtKB=A3C4N5	Serine/threonine-protein phosphatase PP2A-4 catalytic subunit	NAS			PTHR11668:SF247	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	P01486	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	RAT|RGD=67366|UniProtKB=P50393	Cytosolic phospholipase A2	IEA	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01072	CHT1	CAEEL|WormBase=WBGene00000501|UniProtKB=O02228	High-affinity choline transporter 1	IC			PTHR11819:SF12	HIGH-AFFINITY CHOLINE TRANSPORTER 1
P00048	PI3 kinase pathway	P01178	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8617307	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00057	Wnt signaling pathway	P01438	PP2A	XENTR|Xenbase=XB-GENE-484003|UniProtKB=Q6P365	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00068	amine translocator	MACMU|Ensembl=ENSMMUG00000021544|UniProtKB=F7FAK3	Transporter	ISS	12719981	PubMed	PTHR11616:SF102	SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER SLC6A17
P00057	Wnt signaling pathway	P01428	Frizzled	BOVIN|Ensembl=ENSBTAG00000035084|UniProtKB=F1MLG5	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF22	FRIZZLED-3
P00004	Alzheimer disease-presenilin pathway	P00139	E-cadherin transmembrane fragment	XENTR|Xenbase=XB-GENE-482277|UniProtKB=F6QAX3	Uncharacterized protein	ISS	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MACMU|Gene=CCR3|UniProtKB=P56483	C-C chemokine receptor type 3	IDA	11830666	PubMed	PTHR10489:SF649	C-C CHEMOKINE RECEPTOR TYPE 3
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	YEAST|SGD=S000001857|UniProtKB=P02557	Tubulin beta chain	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	RAT|RGD=621516|UniProtKB=G3V6P8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P04398	p53 pathway feedback loops 2	P04651	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	HUMAN|HGNC=18123|UniProtKB=Q8NER5	Activin receptor type-1C	TAS	10683140	PubMed	PTHR23255:SF58	ACTIVIN RECEPTOR TYPE-1C
P00005	Angiogenesis	P00209	FAK	CHICK|Ensembl=ENSGALG00000016171|UniProtKB=Q00944	Focal adhesion kinase 1	ISS	9182576	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00310	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05913	Enkephalin release	P05974	G-Protein (i)	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	IC	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00037	Ionotropic glutamate receptor pathway	P01006	NR2C	MOUSE|MGI=MGI=95822|UniProtKB=Q01098	Glutamate receptor ionotropic, NMDA 2C	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00018	EGF receptor signaling pathway	P00541	Spry	RAT|RGD=1309293|UniProtKB=B5DFH3	Protein Spry1	ISS	12882970	PubMed	PTHR12365:SF10	PROTEIN SPROUTY HOMOLOG 1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01153	GSK3	SCHPO|PomBase=SPBC8D2.01|UniProtKB=Q9URT9	Protein kinase gsk31	ISS	21361340	gi	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00036	Interleukin signaling pathway	P00972	MNK1/2	MACMU|Ensembl=ENSMMUG00000020162|UniProtKB=F6TJV6	Uncharacterized protein	ISS	9155018	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00049	Parkinson disease	P01238	14-3-3	RAT|RGD=61998|UniProtKB=P35213	14-3-3 protein beta/alpha	ISS	1671102	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00029	Huntington disease	P00801	Fos protein	MACMU|Ensembl=ENSMMUG00000010574|UniProtKB=A5A6H2	C-fos	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00036	Interleukin signaling pathway	P00964	p90RSK	DROME|FlyBase=FBgn0262866|UniProtKB=Q9VR61	Ribosomal protein S6 kinase II, isoform A	ISS	6755374	gi	PTHR24351:SF110	RIBOSOMAL PROTEIN S6 KINASE II, ISOFORM A
P00019	Endothelin signaling pathway	P00566	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00036	Interleukin signaling pathway	P00964	p90RSK	HUMAN|HGNC=10432|UniProtKB=P51812	Ribosomal protein S6 kinase alpha-3	ISS	6755374	gi	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IDA	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00922	Collagen	MOUSE|MGI=MGI=1858212|UniProtKB=Q9JLI2	Collagen type V alpha 3 chain	IDA	10778855	PubMed	PTHR24023:SF567	COLLAGEN ALPHA-3 V  CHAIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	NEUCR|EnsemblGenome=EFNCRG00000004240|UniProtKB=Q01386	cAMP-dependent protein kinase regulatory subunit	IC	97076137	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01173	STAT	CANLF|Ensembl=ENSCAFG00000015213|UniProtKB=E2RB82	Signal transducer and activator of transcription	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02774	Salvage pyrimidine deoxyribonucleotides	P03146	Deoxyuridine kinase	CHICK|Ensembl=ENSGALG00000007191|UniProtKB=P04047	Thymidine kinase, cytosolic	ISS			PTHR11441:SF0	THYMIDINE KINASE, CYTOSOLIC
P00005	Angiogenesis	P00219	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00046	Oxidative stress response	P01135	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	TAS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04579	Shc	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	IDA	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	BRADU|Gene=BAC52761|UniProtKB=Q89DE3	tRNA-specific adenosine deaminase	ISS			PTHR11079:SF149	TRNA-SPECIFIC ADENOSINE DEAMINASE
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	CAEEL|WormBase=WBGene00001679|UniProtKB=P17343	Guanine nucleotide-binding protein subunit beta-1	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00053	T cell activation	P01332	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IDA	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04398	p53 pathway feedback loops 2	P04657	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00552	Ras	CRYNJ|EnsemblGenome=CNA02810|UniProtKB=P0CQ42	Ras-like protein	NAS	7997267	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00053	T cell activation	P01300	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	DANRE|ZFIN=ZDB-GENE-040108-2|UniProtKB=Q1RLX8	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF775	SUBFAMILY NOT NAMED
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P02768	Proline biosynthesis	P03114	Glutamyl kinase	LEPIN|EnsemblGenome=LA_0853|UniProtKB=P94871	Glutamate 5-kinase	ISS			PTHR43654:SF3	GLUTAMATE 5-KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	MOUSE|MGI=MGI=102705|UniProtKB=P63213	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IDA			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00049	Parkinson disease	P01235	Fyn kinase	BOVIN|Ensembl=ENSBTAG00000011851|UniProtKB=A0JNB0	Tyrosine-protein kinase Fyn	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00019	Endothelin signaling pathway	P00591	PLCbeta	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01174	Rho	BOVIN|Ensembl=ENSBTAG00000016501|UniProtKB=F6RWK1	Uncharacterized protein	ISS	14724572	PubMed	PTHR23176:SF28	RHO GTPASE-ACTIVATING PROTEIN 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	ARATH|TAIR=AT5G07880|UniProtKB=Q9SD96	SNAP25 homologous protein SNAP29	IC			PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00010	B cell activation	P00383	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	IDA	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	TAS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	TAS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CHICK|Ensembl=ENSGALG00000007794|UniProtKB=A9YZQ5	Dopamine receptor 2 protein transcript variant 1	ISS	11248120	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04393	Ras Pathway	P04570	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	HUMAN|HGNC=2514|UniProtKB=P35222	Catenin beta-1	IDA	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00852	PYK2	MOUSE|MGI=MGI=104908|UniProtKB=Q9QVP9	Protein-tyrosine kinase 2-beta	IDA	12640026	PubMed	PTHR24418:SF94	PROTEIN-TYROSINE KINASE 2-BETA
P00059	p53 pathway	P04633	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00021	FGF signaling pathway	P00625	MKK3,6	CANLF|Ensembl=ENSCAFG00000018530|UniProtKB=F1PXD3	Uncharacterized protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MACMU|Gene=CHRM1|UniProtKB=P56489	Muscarinic acetylcholine receptor M1	IDA	11166329	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	SCLS1|Gene=SS1G_08733|UniProtKB=A7ETS6	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00019	Endothelin signaling pathway	P00586	Gq	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00047	PDGF signaling pathway	P01162	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	TAS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00036	Interleukin signaling pathway	P00979	MAPKAPK2	MACMU|Ensembl=ENSMMUG00000023567|UniProtKB=F7HHY8	Uncharacterized protein	ISS	10779545	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00005	Angiogenesis	P00182	p38MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	RAT|RGD=2732|UniProtKB=P22756	Glutamate receptor ionotropic, kainate 1	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P02748	Isoleucine biosynthesis	P02994	Branched chain amino acid aminotransferase	NEUCR|Gene=NCU04292|UniProtKB=Q1K779	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF69	SUBFAMILY NOT NAMED
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00092	TACE	HUMAN|HGNC=195|UniProtKB=P78536	Disintegrin and metalloproteinase domain-containing protein 17	IDA	12834808	PubMed	PTHR11905:SF171	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00054	Toll receptor signaling pathway	P01358	ERK1	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00029	Huntington disease	P00780	Microtubule	STRPU|EnsemblGenome=SPU_000062|UniProtKB=W4X9L8	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	DANRE|ZFIN=ZDB-GENE-020125-3|UniProtKB=E7F1V8	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00037	Ionotropic glutamate receptor pathway	P01026	KA	CANLF|Ensembl=ENSCAFG00000004930|UniProtKB=E2RFB5	Uncharacterized protein	ISS	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	ORYSJ|EnsemblGenome=OS01G0252100|UniProtKB=Q9LIS6	Os01g0252100 protein	TAS			PTHR24057:SF13	SHAGGY-RELATED PROTEIN KINASE ALPHA-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00558	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00034	Integrin signalling pathway	P00916	Ras	CHICK|Ensembl=ENSGALG00000006885|UniProtKB=P08642	GTPase HRas	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00021	FGF signaling pathway	P00633	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2523|UniProtKB=P25115	D(1B) dopamine receptor	IDA			PTHR43893:SF8	D 1B  DOPAMINE RECEPTOR
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	IC	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IC	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	TAS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	ORYSJ|EnsemblGenome=OS07G0694000|UniProtKB=Q6Z3Y9	Phosphoinositide phospholipase C	TAS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00018	EGF receptor signaling pathway	P00561	STAT	CANLF|Ensembl=ENSCAFG00000000163|UniProtKB=F1PAY3	Signal transducer and activator of transcription	ISS	94367369	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00047	PDGF signaling pathway	P01168	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00009	Axon guidance mediated by netrin	P00359	NFAT	RAT|RGD=1308692|UniProtKB=A0A0G2JTY4	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 (Predicted), isoform CRA_b	ISS	12015605	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ORNAN|Ensembl=ENSOANG00000000460|UniProtKB=F7F4W9	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P06587	Nicotine pharmacodynamics pathway	P06602	PPP1CA	BOVIN|Gene=PPP1CB|UniProtKB=Q3SWW9	Serine/threonine-protein phosphatase PP1-beta catalytic subunit	ISS	10433257	PubMed	PTHR11668:SF282	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-BETA CATALYTIC SUBUNIT
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00260	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05915	Opioid proenkephalin pathway	P05991	Enkephalin	DANRE|ZFIN=ZDB-GENE-030729-3|UniProtKB=F1QTD1	Uncharacterized protein (Fragment)	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00034	Integrin signalling pathway	P00947	Laminin	RAT|RGD=1308330|UniProtKB=D4A3L3	EGF-like-domain, multiple 5 (Predicted)	ISS	2538453	PubMed	PTHR10574:SF298	MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN 9
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CHICK|Ensembl=ENSGALG00000013781|UniProtKB=F1P1D5	Uncharacterized protein	IC	10938134	PubMed	PTHR13140:SF344	MYOSIN-7
P00057	Wnt signaling pathway	P01452	NFAT	BOVIN|Ensembl=ENSBTAG00000018270|UniProtKB=F1MGR9	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00047	PDGF signaling pathway	P01143	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	18021322	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00034	Integrin signalling pathway	P00913	Csk	MONDO|Ensembl=ENSMODG00000009310|UniProtKB=F7GJZ7	Tyrosine-protein kinase	ISS	12665526	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00010	B cell activation	P00371	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02746	Heme biosynthesis	P02982	Protoheme IX farnesyl transferase	AQUAE|EnsemblGenome=aq_154|UniProtKB=O66544	Protoheme IX farnesyltransferase	ISS			PTHR43448:SF2	PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00113	Erb-B4 transmembrane fragment	MONDO|Ensembl=ENSMODG00000015755|UniProtKB=F6ZSZ9	Uncharacterized protein (Fragment)	ISS	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05918	p38 MAPK pathway	P06044	GADD45	PANTR|Ensembl=ENSPTRG00000000842|UniProtKB=H2R902	Growth arrest and DNA-damage-inducible, alpha	ISS	10097101	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	20264070	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02738	De novo purine biosynthesis	P02900	AICAR transformylase	CANLF|Ensembl=ENSCAFG00000014303|UniProtKB=F1P797	Uncharacterized protein	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000005862|UniProtKB=F1PL99	Phosphoinositide phospholipase C	ISS			PTHR10336:SF84	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	DANRE|ZFIN=ZDB-GENE-991119-4|UniProtKB=Q9W6T7	Presenilin-1	IDA	12101103	PubMed	PTHR10202:SF18	PRESENILIN-1
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00048	PI3 kinase pathway	P01179	PKB	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	TAS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01211	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00057	Wnt signaling pathway	P01438	PP2A	DANRE|ZFIN=ZDB-GENE-040426-2487|UniProtKB=Q803G3	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P02748	Isoleucine biosynthesis	P02995	Threonine dehydratase	THEMA|EnsemblGenome=TM_0356|UniProtKB=Q9WYJ1	Threonine dehydratase	ISS			PTHR43419:SF8	THREONINE AMMONIA-LYASE
P00057	Wnt signaling pathway	P01456	beta-arrestin	MOUSE|MGI=MGI=99474|UniProtKB=Q91YI4	Beta-arrestin-2	IDA	11742073	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P05913	Enkephalin release	P05975	GPCR (s)	PANTR|Gene=OPRM1|UniProtKB=Q5IS39	Mu-type opioid receptor	ISS	11259487	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00021	FGF signaling pathway	P00636	FGFR1-4	BOVIN|Ensembl=ENSBTAG00000014064|UniProtKB=F1MNW2	Fibroblast growth factor receptor	ISS	1373495	PubMed	PTHR24416:SF130	FIBROBLAST GROWTH FACTOR RECEPTOR 2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P06664	Gonadotropin-releasing hormone receptor pathway	P06768	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	RCA	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00010	B cell activation	P00384	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00036	Interleukin signaling pathway	P00996	STAT	DANRE|ZFIN=ZDB-GENE-980526-499|UniProtKB=Q6P943	Signal transducer and activator of transcription	IDA	10417824	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04556	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	15737619	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	XENTR|Xenbase=XB-GENE-967585|UniProtKB=Q28BZ0	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	STRCO|Gene=CAB61810|UniProtKB=Q9RKF1	Putative aldehyde dehydrogenase	IC			PTHR43353:SF4	LACTALDEHYDE DEHYDROGENASE
P00018	EGF receptor signaling pathway	P00561	STAT	TAKRU|Ensembl=ENSTRUG00000000102|UniProtKB=H2RJA9	Signal transducer and activator of transcription	ISS	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MOUSE|MGI=MGI=2444552|UniProtKB=Q8BFZ3	Beta-actin-like protein 2	ISS	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P04393	Ras Pathway	P04556	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	3449797	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00053	T cell activation	P01322	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=7571|UniProtKB=Q9UKX3	Myosin-13	IC	10938134	PubMed	PTHR13140:SF504	MYOSIN-13
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	TAS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00021	FGF signaling pathway	P00639	Shc	CANLF|Ensembl=ENSCAFG00000002201|UniProtKB=F1PPW0	Uncharacterized protein	ISS	8760305	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00053	T cell activation	P01306	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00029	Huntington disease	P00796	Kainate receptor	HUMAN|HGNC=4580|UniProtKB=Q13002	Glutamate receptor ionotropic, kainate 2	IDA	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	MACMU|Ensembl=ENSMMUG00000002061|UniProtKB=F6WWR1	Uncharacterized protein	ISS			PTHR42884:SF12	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 7
P00036	Interleukin signaling pathway	P00964	p90RSK	MACMU|Ensembl=ENSMMUG00000022111|UniProtKB=F7H7W3	Ribosomal protein S6 kinase	ISS	12769834	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P05730	Endogenous cannabinoid signaling	P05751	Galpha	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P02752	Mannose metabolism	P03018	Mannose 1-P guanylyl transferase	CAEEL|WormBase=WBGene00021628|UniProtKB=Q9N4V3	Uncharacterized protein	TAS	17509979	gi	PTHR22572:SF104	MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	MONDO|Ensembl=ENSMODG00000000981|UniProtKB=F7ES59	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00059	p53 pathway	P04634	Cdc2	HUMAN|HGNC=1722|UniProtKB=P06493	Cyclin-dependent kinase 1	ISS			PTHR24056:SF334	CYCLIN-DEPENDENT KINASE 1
P00056	VEGF signaling pathway	P01408	Akt/PKB	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	ISS	12655147	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	CANLF|Ensembl=ENSCAFG00000028848|UniProtKB=J9NRZ4	Uncharacterized protein	ISS	10664585	PubMed	PTHR11462:SF37	TRANSCRIPTION FACTOR JUN-B
P00046	Oxidative stress response	P01135	p38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00021	FGF signaling pathway	P00629	PP2A	ORNAN|Ensembl=ENSOANG00000009097|UniProtKB=F7G755	Uncharacterized protein	ISS	11007767	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	ANOGA|EnsemblGenome=AGAP005911|UniProtKB=Q7Q6D4	AGAP005911-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00021	FGF signaling pathway	P00629	PP2A	RAT|RGD=6503746|UniProtKB=Q80W83	Protein LOC100909468	ISS	96161994	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	RCA	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	TAS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	IDA	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	PANTR|Ensembl=ENSPTRG00000001749|UniProtKB=H2Q0Q4	Uncharacterized protein	ISS	8386525	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	XENTR|GeneID=394982|UniProtKB=P20399	Actin, alpha cardiac muscle 2	ISS	14684598	PubMed	PTHR11937:SF263	ACTIN
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00890	ELK	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	ISS	9644975	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	PLAF7|EnsemblGenome=PFD0755c|UniProtKB=Q8I1T1	GTP:AMP phosphotransferase	ISS			PTHR23359:SF22	GTP:AMP PHOSPHOTRANSFERASE, MITOCHONDRIAL
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00047	PDGF signaling pathway	P01162	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00079	alpha7 nicotinic acetylcholine receptor	CHICK|Gene=CHRNA7|UniProtKB=P22770	Neuronal acetylcholine receptor subunit alpha-7	IDA	11404397	PubMed	PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P00059	p53 pathway	G04702	p53	HUMAN|HGNC=11998|UniProtKB=P04637	Cellular tumor antigen p53	TAS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00021	FGF signaling pathway	P00627	ERK1-2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00233	CSL	RAT|RGD=1310557|UniProtKB=F1LNW1	Protein Rbpj	ISS	9528780	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	IC	1333286	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	XENTR|Xenbase=XB-GENE-967585|UniProtKB=Q28BZ0	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00034	Integrin signalling pathway	P00907	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=1308054|UniProtKB=Q5XIS9	Serine/threonine-protein kinase D2	ISS	11062248	PubMed	PTHR22968:SF12	SERINE/THREONINE-PROTEIN KINASE D2
P00005	Angiogenesis	P00211	GSK3beta	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00001	Adrenaline and noradrenaline biosynthesis	P00061	PNMT	XENTR|Ensembl=ENSXETG00000026030|UniProtKB=L7N2T4	Uncharacterized protein (Fragment)	ISS			PTHR10867:SF5	NICOTINAMIDE N-METHYLTRANSFERASE
P02772	Pyruvate metabolism	P03140	Pyruvate Carboxylase	BOVIN|Ensembl=ENSBTAG00000019700|UniProtKB=Q29RK2	Pyruvate carboxylase, mitochondrial	ISS	200246	gi	PTHR43778:SF2	PYRUVATE CARBOXYLASE, MITOCHONDRIAL
P00001	Adrenaline and noradrenaline biosynthesis	P00068	amine translocator	ANOGA|EnsemblGenome=AGAP011279|UniProtKB=Q7PSR4	Transporter (Fragment)	IC	12719981	PubMed	PTHR11616:SF187	TRANSPORTER
P04393	Ras Pathway	P04559	Rac	ORNAN|Ensembl=ENSOANG00000013618|UniProtKB=F7FH99	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00021	FGF signaling pathway	P00629	PP2A	HUMAN|HGNC=9305|UniProtKB=Q00005	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform	IPI	12110603	PubMed	PTHR11871:SF1	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B BETA ISOFORM
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	MOUSE|MGI=MGI=96435|UniProtKB=Q07113	Cation-independent mannose-6-phosphate receptor	ISS	13642251	gi	PTHR15071:SF17	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
P04393	Ras Pathway	P04564	MAPKAP	MOUSE|MGI=MGI=109298|UniProtKB=P49138	MAP kinase-activated protein kinase 2	IDA	14672329	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00057	Wnt signaling pathway	P01435	SWI/SNF	PANTR|Ensembl=ENSPTRG00000006939|UniProtKB=H2R3P6	INO80 homolog	ISS	11532957	PubMed	PTHR10799:SF868	DNA HELICASE INO80
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00049	Parkinson disease	P01235	Fyn kinase	CHICK|Gene=FYN|UniProtKB=Q05876	Tyrosine-protein kinase Fyn	IDA	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MACMU|Gene=FPR1|UniProtKB=P79189	fMet-Leu-Phe receptor (Fragment)	ISS	7305065	gi	PTHR24225:SF15	FMET-LEU-PHE RECEPTOR
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00572	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00059	p53 pathway	P01486	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00029	Huntington disease	P00779	TBP	DROME|FlyBase=FBgn0003687|UniProtKB=P20227	TATA-box-binding protein	IPI	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00023	General transcription regulation	P00660	RNA Polymerase II	RAT|RGD=1561203|UniProtKB=G3V678	Protein LOC100912534	ISS	606023	OMIM	PTHR10917:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3
P00021	FGF signaling pathway	P00629	PP2A	CANLF|Ensembl=ENSCAFG00000006453|UniProtKB=F6X958	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01174	Rho	PANTR|Ensembl=ENSPTRG00000021979|UniProtKB=Q7YQL6	Oligophrenin-1	ISS			PTHR12552:SF2	OLIGOPHRENIN-1
P00018	EGF receptor signaling pathway	P00554	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	8264585	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00035	Interferon-gamma signaling pathway	P00958	PIAS	ORNAN|Ensembl=ENSOANG00000012017|UniProtKB=F7DX37	Uncharacterized protein	ISS	8682149	PubMed	PTHR10782:SF12	E3 SUMO-PROTEIN LIGASE PIAS2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IC	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CHICK|Ensembl=ENSGALG00000009621|UniProtKB=P60706	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	HUMAN|HGNC=8528|UniProtKB=P01178	Oxytocin-neurophysin 1	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00046	Oxidative stress response	P01137	MNK1/2	HUMAN|HGNC=7110|UniProtKB=Q9BUB5	MAP kinase-interacting serine/threonine-protein kinase 1	RCA	9155018	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00059	p53 pathway	P04609	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	RAT|RGD=2626|UniProtKB=P12841	Proto-oncogene c-Fos	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00057	Wnt signaling pathway	P01435	SWI/SNF	CANLF|Ensembl=ENSCAFG00000008306|UniProtKB=J9P148	Uncharacterized protein	ISS	11532957	PubMed	PTHR13844:SF1	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D MEMBER 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	IC	http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00057	Wnt signaling pathway	P01456	beta-arrestin	HUMAN|HGNC=712|UniProtKB=P32121	Beta-arrestin-2	IDA	9388255	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	HUMAN|HGNC=4401|UniProtKB=O14775	Guanine nucleotide-binding protein subunit beta-5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00046	Oxidative stress response	P01128	MEF-2	CAEEL|WormBase=WBGene00003182|UniProtKB=Q9U325	Related to vertebrate MEF2 transcription factor	TAS	11274345	PubMed	PTHR11945:SF277	MYOCYTE-SPECIFIC ENHANCER FACTOR 2
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00320	SODD	MACMU|Ensembl=ENSMMUG00000013775|UniProtKB=F6Q0J1	Uncharacterized protein	ISS	9915703	PubMed	PTHR12329:SF10	BAG FAMILY MOLECULAR CHAPERONE REGULATOR 4
P00019	Endothelin signaling pathway	P00591	PLCbeta	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04570	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P01485	p53	PANTR|Ensembl=ENSPTRG00000008703|UniProtKB=H2QC53	Cellular tumor antigen p53	ISS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	ARATH|TAIR=AT3G02160|UniProtKB=Q9S7R9	At3g02160	ISS	604905	OMIM	PTHR12321:SF53	BROMODOMAIN TRANSCRIPTION FACTOR
P00004	Alzheimer disease-presenilin pathway	P00165	E-cadherin N-terminal fragment	PANTR|Ensembl=ENSPTRG00000008269|UniProtKB=H2QBE4	Cadherin 3, type 1, P-cadherin (Placental)	ISS	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	IC	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00010	B cell activation	P00380	fos	BOVIN|Ensembl=ENSBTAG00000004322|UniProtKB=O77628	Proto-oncogene c-Fos	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IC	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00645	Rac	DICDI|dictyBase=DDB_G0268622|UniProtKB=P34145	Rho-related protein rac1B	ISS	21127961	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	TAKRU|Ensembl=ENSTRUG00000016101|UniProtKB=H2UW32	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00046	Oxidative stress response	P01129	JNK1/2	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8674|UniProtKB=Q9Y5H6	Protocadherin alpha-8	IDA	8120095	PubMed	PTHR24028:SF147	PROTOCADHERIN ALPHA-8
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MONDO|Ensembl=ENSMODG00000005623|UniProtKB=F7CFG8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00012	Cadherin signaling pathway	P00474	Wnt	MACMU|Ensembl=ENSMMUG00000007765|UniProtKB=F7CW57	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	IGI	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00018	EGF receptor signaling pathway	P00562	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	YEAST|SGD=S000000028|UniProtKB=P31109	Synaptobrevin homolog 1	IC			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00045	Notch signaling pathway	P01120	NIcs	RAT|RGD=1303282|UniProtKB=Q6MG89	Notch homolog 4, [Drosophila]	ISS	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P04393	Ras Pathway	P04557	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02772	Pyruvate metabolism	P03132	Pyruvate Kinase	SULSO|EnsemblGenome=SSO0981|UniProtKB=Q97ZD7	Pyruvate kinase	ISS	11427726	PubMed	PTHR11817:SF3	AT14039P-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00925	MEK	ORNAN|Ensembl=ENSOANG00000007732|UniProtKB=F6PXH5	Uncharacterized protein (Fragment)	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00029	Huntington disease	P00777	CBP	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00049	Parkinson disease	P01238	14-3-3	DANRE|ZFIN=ZDB-GENE-030131-779|UniProtKB=Q7ZW20	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00036	Interleukin signaling pathway	P00983	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	TRYB2|Gene=Tb09.211.4890|UniProtKB=Q38D21	Casein kinase II, putative	ISS	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04542	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00189	Fzd	BOVIN|Ensembl=ENSBTAG00000020957|UniProtKB=F1MGM1	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF126	FRIZZLED-5
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	XENTR|Xenbase=XB-GENE-488460|UniProtKB=Q6DIY4	TATA box-binding protein-like protein 1	ISS	10470030	PubMed	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00581	Guanylate cyclase	MOUSE|MGI=MGI=1926562|UniProtKB=Q9ERL9	Guanylate cyclase soluble subunit alpha-3	RCA			PTHR11920:SF226	GUANYLATE CYCLASE SOLUBLE SUBUNIT ALPHA-3
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00010	B cell activation	P00397	IKK	CANLF|Ensembl=ENSCAFG00000009588|UniProtKB=E2RNA9	Uncharacterized protein	ISS	12813046	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2747|UniProtKB=P35349	Metabotropic glutamate receptor 6	IDA	11431030	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	BOVIN|Gene=ADRBK1|UniProtKB=P21146	Beta-adrenergic receptor kinase 1	RCA			PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P04393	Ras Pathway	P04556	Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	IDA	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	RAT|RGD=619965|UniProtKB=P26769	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	PANTR|Ensembl=ENSPTRG00000019904|UniProtKB=H2QVN5	Uncharacterized protein	ISS			PTHR24247:SF108	5-HYDROXYTRYPTAMINE RECEPTOR 5A
P00034	Integrin signalling pathway	P00922	Collagen	CANLF|Gene=COL4A5|UniProtKB=Q28247	Collagen alpha-5(IV) chain	ISS	10778855	PubMed	PTHR24023:SF847	COLLAGEN ALPHA-5 IV  CHAIN
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IDA	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P05731	GABA-B receptor II signaling	P05755	Gbeta	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00057	Wnt signaling pathway	P01455	Smad4	CHICK|Ensembl=ENSGALG00000009977|UniProtKB=Q56IA0	Mothers against decapentaplegic homolog	ISS	12736218	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P06587	Nicotine pharmacodynamics pathway	P06614	TH	PANTR|Ensembl=ENSPTRG00000003173|UniProtKB=H2Q2W7	Uncharacterized protein	ISS	12814656	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00029	Huntington disease	P00774	Dynein complex	CAEEL|WormBase=WBGene00000962|UniProtKB=Q19020	Dynein heavy chain, cytoplasmic	IPI	9454836	PubMed	PTHR10676:SF314	CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1
P00034	Integrin signalling pathway	P00944	Actin	DANRE|ZFIN=ZDB-GENE-000329-3|UniProtKB=Q7ZVF9	Actin, cytoplasmic 2	ISS	3487386	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00029	Huntington disease	P00786	ARF	BATDJ|Gene=BATDEDRAFT_36333|UniProtKB=F4NRM0	ADP-Ribosylation factor	ISS	12932731	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00060	Ubiquitin proteasome pathway	P01491	E2	CANAL|CGD=CAL0000194082|UniProtKB=O74201	Ubiquitin-conjugating enzyme E2 2	ISS			PTHR43898:SF1	UBIQUITIN-CONJUGATING ENZYME E2-17 KDA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00048	PI3 kinase pathway	P01199	Galpha	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00018	EGF receptor signaling pathway	P00547	PP2A	BOVIN|Ensembl=ENSBTAG00000019784|UniProtKB=A4FV68	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	ISS	8703017	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00045	Notch signaling pathway	P01110	Presenilin	XENTR|Xenbase=XB-GENE-481916|UniProtKB=F6YF14	Presenilin	ISS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00010	B cell activation	P00398	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	ARATH|TAIR=AT1G07880|UniProtKB=Q9LQQ9	Mitogen-activated protein kinase 13	ISS			PTHR24055:SF185	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	BOVIN|Ensembl=ENSBTAG00000008026|UniProtKB=P01175	Oxytocin-neurophysin 1	ISS	1706187	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	CANLF|Ensembl=ENSCAFG00000016335|UniProtKB=J9NXY2	Uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF322	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	ANOGA|EnsemblGenome=AGAP006475|UniProtKB=Q5TQX0	AGAP006475-PA	IDA	11007872	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00010	B cell activation	P00384	p38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P05913	Enkephalin release	P05974	G-Protein (i)	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00021	FGF signaling pathway	P00644	p38	CAEEL|WormBase=WBGene00004055|UniProtKB=Q17446	Mitogen-activated protein kinase pmk-1	IGI	22138445	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	EMENI|EnsemblGenome=CADANIAG00001764|UniProtKB=Q5BEY7	Adenylosuccinate synthetase	IEP	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	XENTR|Xenbase=XB-GENE-482228|UniProtKB=F6RYL1	Uncharacterized protein	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00048	PI3 kinase pathway	P01188	Gbetagamma	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00570	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00546	GAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	88318957	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00018	EGF receptor signaling pathway	P00551	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	SCHPO|PomBase=SPBC32H8.07|UniProtKB=Q10282	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00897	SHIP2	MACMU|Ensembl=ENSMMUG00000010451|UniProtKB=F7CRA7	Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2	ISS	10610720	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00053	T cell activation	P01331	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00006	Apoptosis signaling pathway	P00295	Caspase 10	PANTR|Ensembl=ENSPTRG00000012800|UniProtKB=H2R694	Uncharacterized protein	ISS	11717445	PubMed	PTHR10454:SF26	CASPASE-10
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	IDA	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00006	Apoptosis signaling pathway	P00302	ATF	BOVIN|Ensembl=ENSBTAG00000002295|UniProtKB=F1N177	Uncharacterized protein	ISS	10487205	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00034	Integrin signalling pathway	P00942	Fyn	BOVIN|Ensembl=ENSBTAG00000011851|UniProtKB=A0JNB0	Tyrosine-protein kinase Fyn	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00060	Ubiquitin proteasome pathway	P01490	E3	MACMU|Ensembl=ENSMMUG00000020980|UniProtKB=F7HMU2	Uncharacterized protein	ISS			PTHR10953:SF143	UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 7
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	DANRE|ZFIN=ZDB-GENE-030131-825|UniProtKB=Q7T2E3	Casein kinase I isoform delta-A	ISS	11437445	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P02746	Heme biosynthesis	P02970	Coproporphyrinogen oxidase (oxygen independent)	DEIRA|EnsemblGenome=DR_0130|UniProtKB=Q9RY22	Coproporphyrinogen III oxidase	ISS			PTHR13932:SF5	OXYGEN-INDEPENDENT COPROPORPHYRINOGEN-III OXIDASE-LIKE PROTEIN YGGW
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	LEIMA|EnsemblGenome=LmjF.35.1000|UniProtKB=Q9NHE2	Casein kinase 1 isoform 1	IDA	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	RAT|RGD=69281|UniProtKB=P43143	Neuronal acetylcholine receptor subunit alpha-6	ISS	85270494	PubMed	PTHR18945:SF82	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-6
P00030	Hypoxia response via HIF activation	P00825	Thioredoxin	RAT|RGD=621157|UniProtKB=P11232	Thioredoxin	ISS	12115731	PubMed	PTHR10438:SF18	THIOREDOXIN
P02746	Heme biosynthesis	P02970	Coproporphyrinogen oxidase (oxygen independent)	CHLTR|EnsemblGenome=CT_052|UniProtKB=O84055	Coproporphyrinogen III Oxidase	ISS			PTHR13932:SF5	OXYGEN-INDEPENDENT COPROPORPHYRINOGEN-III OXIDASE-LIKE PROTEIN YGGW
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00056	VEGF signaling pathway	P01411	Ras	BOVIN|Ensembl=ENSBTAG00000009778|UniProtKB=E1BMX0	Uncharacterized protein	ISS	3023884	PubMed	PTHR24070:SF186	GTPASE KRAS
P05915	Opioid proenkephalin pathway	P05989	leu-Enkephalin	RAT|RGD=68946|UniProtKB=P04094	Proenkephalin-A	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P06664	Gonadotropin-releasing hormone receptor pathway	P06807	gnai	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DROME|FlyBase=FBgn0001122|UniProtKB=P16378	G protein alpha o subunit	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01444	Wnt	MACMU|Ensembl=ENSMMUG00000022937|UniProtKB=F6U717	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P00013	Cell cycle	P00484	Cyclin D	MACMU|Ensembl=ENSMMUG00000002368|UniProtKB=F7BZY1	Uncharacterized protein	ISS	12356903	PubMed	PTHR10177:SF67	G1/S-SPECIFIC CYCLIN-D1
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	CAEEL|WormBase=WBGene00000295|UniProtKB=Q9GNP0	Uncharacterized protein	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P04393	Ras Pathway	P04558	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	IDA	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	RAT|RGD=1308817|UniProtKB=Q4V8D6	Transcription factor IIIB 50 kDa subunit	ISS			PTHR11618:SF5	TRANSCRIPTION FACTOR IIIB 50 KDA SUBUNIT
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00021	FGF signaling pathway	P00629	PP2A	DANRE|ZFIN=ZDB-GENE-040927-20|UniProtKB=Q642H5	Protein phosphatase 2 (Formerly 2A), regulatory subunit A, beta isoform	ISS			PTHR10648:SF4	PROTEIN PHOSPHATASE 2  FORMERLY 2A , REGULATORY SUBUNIT A, BETA ISOFORM
P00005	Angiogenesis	P00256	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P02727	Androgen/estrogene/progesterone biosynthesis	P02833	3beta-Hydroxysteroid dehydrogenase	BOVIN|Ensembl=ENSBTAG00000006769|UniProtKB=P14893	3 beta-hydroxysteroid dehydrogenase/Delta 5--4-isomerase	ISS	2599102	PubMed	PTHR10366:SF364	3 BETA-HYDROXYSTEROID DEHYDROGENASE/DELTA 5--4-ISOMERASE TYPE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	RAT|RGD=1307994|UniProtKB=B6RK61	Myosin heavy chain 7B	ISS	10938134	PubMed	PTHR13140:SF358	MYOSIN-7B
P00016	Cytoskeletal regulation by Rho GTPase	P00524	LIMK	RAT|RGD=62055|UniProtKB=P53669	LIM domain kinase 1	ISS			PTHR44124:SF1	LIM DOMAIN KINASE 1
P00006	Apoptosis signaling pathway	P00317	Fos	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04384	Gamma-aminobutyric acid synthesis	P04480	GABA aminotransferase	YEAST|SGD=S000003251|UniProtKB=P17649	4-aminobutyrate aminotransferase	ISS	2190186	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00029	Huntington disease	P00799	JNK-2	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00024	Glycolysis	P00677	Hexokinase	PANTR|Ensembl=ENSPTRG00000012104|UniProtKB=H2QI73	Hexokinase 2	RCA			PTHR19443:SF4	HEXOKINASE-2
P00057	Wnt signaling pathway	P01434	sFRP	MOUSE|MGI=MGI=1860298|UniProtKB=Q9WU66	Secreted frizzled-related protein 5	ISS	9096311	PubMed	PTHR11309:SF46	SECRETED FRIZZLED-RELATED PROTEIN 5
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	BOVIN|Ensembl=ENSBTAG00000034854|UniProtKB=F1N246	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00012	Cadherin signaling pathway	P00471	Cadherin	CAEEL|WormBase=WBGene00001980|UniProtKB=Q967F4	Cadherin-related hmr-1	IDA	8120095	PubMed	PTHR24026:SF69	PROTOCADHERIN FAT 4
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEEL|WormBase=WBGene00018620|UniProtKB=O44588	Uncharacterized protein	ISS	2837282	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P00059	p53 pathway	P04633	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00977	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IC	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00011	Blood coagulation	P00408	Plasminogen	BOVIN|Gene=PLG|UniProtKB=P06868	Plasminogen	ISS	2507247	gi	PTHR24261:SF5	PLASMINOGEN
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04395	Vasopressin synthesis	P04589	Signal Peptidase	PANTR|Ensembl=ENSPTRG00000007404|UniProtKB=H2QA06	Signal peptidase complex catalytic subunit SEC11	ISS	2674115	PubMed	PTHR10806:SF8	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11A-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PRIPA|Gene=PPA17339|UniProtKB=H3F5B4	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF352	ACTIN
P00053	T cell activation	P01304	Csk	HUMAN|HGNC=2444|UniProtKB=P41240	Tyrosine-protein kinase CSK	IDA	12665526	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00021	FGF signaling pathway	P00645	Rac	ORYSJ|EnsemblGenome=OS05G0513800|UniProtKB=Q68Y52	Rac-like GTP-binding protein 2	ISS	12932731	PubMed	PTHR24072:SF127	RAC-LIKE GTP-BINDING PROTEIN ARAC7
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00010	B cell activation	P00367	NFAT	MACMU|Ensembl=ENSMMUG00000021843|UniProtKB=F6RNI3	Uncharacterized protein	ISS	12787506	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	HUMAN|HGNC=30262|UniProtKB=Q96C36	Pyrroline-5-carboxylate reductase 2	ISS			PTHR11645:SF4	PYRROLINE-5-CARBOXYLATE REDUCTASE 2
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00907	ERK	PANTR|Ensembl=ENSPTRG00000009518|UniProtKB=H2QDN0	Mitogen-activated protein kinase kinase kinase 3	ISS			PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00188	Ets	RAT|RGD=2583|UniProtKB=P41156	Protein C-ets-1	ISS	15298723	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00012	Cadherin signaling pathway	P00464	Fyn	XENTR|Xenbase=XB-GENE-6053489|UniProtKB=F6S8L5	Tyrosine-protein kinase	ISS	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00021	FGF signaling pathway	P00634	MEKK1-5	CANLF|Ensembl=ENSCAFG00000012934|UniProtKB=F1P750	Uncharacterized protein	ISS	8649450	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00011	Blood coagulation	P00411	PAI-1	HUMAN|HGNC=8583|UniProtKB=P05121	Plasminogen activator inhibitor 1	ISS	18092159	gi	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00056	VEGF signaling pathway	P01409	cPLA2	MACMU|Ensembl=ENSMMUG00000021423|UniProtKB=F7EEZ1	Phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00005	Angiogenesis	P00238	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00012	Cadherin signaling pathway	P00470	F-actin	MOUSE|MGI=MGI=87909|UniProtKB=P62737	Actin, aortic smooth muscle	IC	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00048	PI3 kinase pathway	P01185	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00025	Hedgehog signaling pathway	P00682	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00922	Collagen	MACMU|Ensembl=ENSMMUG00000000544|UniProtKB=F6ZXR6	Uncharacterized protein	ISS	10778855	PubMed	PTHR44172:SF3	COLLAGEN ALPHA-1 VI  CHAIN
P00036	Interleukin signaling pathway	P00981	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	CAEEL|WormBase=WBGene00004769|UniProtKB=P52166	Presenilin sel-12	TAS	7566091	PubMed	PTHR10202:SF13	PRESENILIN-2
P04393	Ras Pathway	P04556	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00472	Tyrosine phosphatases	HUMAN|HGNC=9642|UniProtKB=P18031	Tyrosine-protein phosphatase non-receptor type 1	ISS			PTHR19134:SF239	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IGI	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00056	VEGF signaling pathway	P01411	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	91232861	PubMed	PTHR24070:SF385	GTPASE HRAS
P00005	Angiogenesis	P00243	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	CHICK|Ensembl=ENSGALG00000013781|UniProtKB=F1P1D5	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF344	MYOSIN-7
P00011	Blood coagulation	P00411	PAI-1	MACMU|Ensembl=ENSMMUG00000009926|UniProtKB=F6Y5D7	Uncharacterized protein	ISS	10692390	PubMed	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00006	Apoptosis signaling pathway	P00310	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P05913	Enkephalin release	P05977	G-Protein (s)	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P02731	Biotin biosynthesis	P02857	Biotin synthase	GLOVI|EnsemblGenome=BAC92269|UniProtKB=Q7NDA8	Biotin synthase	ISS			PTHR22976:SF1	BIOTIN SYNTHASE, MITOCHONDRIAL
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	RAT|RGD=67385|UniProtKB=Q8VGC3	Voltage-dependent L-type calcium channel subunit beta-2	IC	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g188243|UniProtKB=A7SCN8	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00047	PDGF signaling pathway	P01173	STAT	MONDO|Ensembl=ENSMODG00000014816|UniProtKB=F7CHH2	Signal transducer and activator of transcription	ISS	96102059	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00056	VEGF signaling pathway	P01417	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00049	Parkinson disease	P01230	Src kinase	TAKRU|Ensembl=ENSTRUG00000014739|UniProtKB=H2UL58	Tyrosine-protein kinase	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	MOUSE|MGI=MGI=1341265|UniProtKB=Q6PHZ2	Calcium/calmodulin-dependent protein kinase type II subunit delta	ISS	12888804	PubMed	PTHR43940:SF4	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT DELTA
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00034	Integrin signalling pathway	P00906	Rap1	MOUSE|MGI=MGI=894315|UniProtKB=Q99JI6	Ras-related protein Rap-1b	ISS	8576107	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	TAS	3755548	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P05913	Enkephalin release	P05977	G-Protein (s)	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04393	Ras Pathway	P04555	PDK	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00034	Integrin signalling pathway	P00948	Rho	MONDO|Ensembl=ENSMODG00000012981|UniProtKB=F7CS91	Uncharacterized protein	ISS	15668138	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00054	Toll receptor signaling pathway	P01352	p38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	SCHMA|EnsemblGenome=Smp_046600|UniProtKB=G4VLW2	Putative actin-1	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	TAS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00056	VEGF signaling pathway	P01411	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00006	Apoptosis signaling pathway	P00305	Caspase 3	TAKRU|Ensembl=ENSTRUG00000015915|UniProtKB=H2UUR6	Uncharacterized protein (Fragment)	ISS	11675509	PubMed	PTHR10454:SF198	CASPASE-3
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PHYPA|Gene=PHYPADRAFT_223215|UniProtKB=Q6TYR8	Beta-tubulin 6	ISS	9454836	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04558	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00025	Hedgehog signaling pathway	P00699	Su(fu)	MACMU|Ensembl=ENSMMUG00000004396|UniProtKB=F7FM83	Suppressor of fused homolog	ISS	12068298	PubMed	PTHR10928:SF2	SUPPRESSOR OF FUSED HOMOLOG
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	HUMAN|HGNC=7571|UniProtKB=Q9UKX3	Myosin-13	ISS	10938134	PubMed	PTHR13140:SF504	MYOSIN-13
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00551	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00024	Glycolysis	P00672	Phosphofructokinase-1	HUMAN|HGNC=8876|UniProtKB=P17858	ATP-dependent 6-phosphofructokinase, liver type	RCA			PTHR13697:SF14	ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE, LIVER TYPE
P00052	TGF-beta signaling pathway	P01284	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	TAS	8946915	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00848	Grb	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12748278	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00029	Huntington disease	P00807	Actin	YARLI|EnsemblGenome=YALI0_D08272g|UniProtKB=Q9UVF3	Actin	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00018	EGF receptor signaling pathway	P00539	14-3-3	DROME|FlyBase=FBgn0004907|UniProtKB=P29310	14-3-3 protein zeta	ISS	10407019	PubMed	PTHR18860:SF13	14-3-3 PROTEIN ZETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00023	General transcription regulation	P00668	TFIIB	RAT|RGD=619735|UniProtKB=P62916	Transcription initiation factor IIB	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P00019	Endothelin signaling pathway	P00580	ET-RA/B	XENTR|Xenbase=XB-GENE-1006994|UniProtKB=Q0VA29	Endothelin receptor type A	ISS	8175772	PubMed	PTHR24243:SF31	ENDOTHELIN-1 RECEPTOR
P02724	Alanine biosynthesis	P02815	Branched chain amino acid aminotransferase	CAEBR|Gene=CBG00050|UniProtKB=A8WM75	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF44	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000002647|UniProtKB=F7DIB7	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	PANTR|Ensembl=ENSPTRG00000001787|UniProtKB=H2Q0T0	Phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00005	Angiogenesis	P00203	Erk	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01192	p110	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	BOVIN|Ensembl=ENSBTAG00000009065|UniProtKB=F1MXH6	Uncharacterized protein	ISS	12968034	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00054	Toll receptor signaling pathway	P01350	TIRAP	RAT|RGD=1595496|UniProtKB=D3ZXA5	Protein Tirap	ISS	21417617	PubMed	PTHR22662:SF0	TOLL/INTERLEUKIN-1 RECEPTOR DOMAIN-CONTAINING ADAPTER PROTEIN
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	SCHPO|PomBase=SPAC6G9.11|UniProtKB=Q92356	Synaptobrevin homolog 1	IC			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P05916	Opioid prodynorphin pathway	P06002	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00012	Cadherin signaling pathway	P00470	F-actin	DANRE|ZFIN=ZDB-GENE-000329-1|UniProtKB=Q7ZVI7	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05915	Opioid proenkephalin pathway	P05994	G-protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	ISS	11535291	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00029	Huntington disease	P00790	beta-Tubulin	STRPU|EnsemblGenome=SPU_007424|UniProtKB=W4XVG8	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF155	TUBULIN BETA-2 CHAIN
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	DROME|FlyBase=FBgn0028685|UniProtKB=Q9W414	Regulatory particle triple-A ATPase 4	ISS			PTHR23073:SF31	26S PROTEASE REGULATORY SUBUNIT 10B
P00047	PDGF signaling pathway	P01159	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00570	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MONDO|Ensembl=ENSMODG00000016595|UniProtKB=F6ZDB2	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01428	Frizzled	HUMAN|HGNC=4040|UniProtKB=Q14332	Frizzled-2	IDA	11212302	PubMed	PTHR11309:SF34	FRIZZLED-2
P04393	Ras Pathway	P04547	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00870	IL2	MOUSE|MGI=MGI=96548|UniProtKB=P04351	Interleukin-2	RCA			PTHR45426:SF1	INTERLEUKIN-2
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	PLAF7|EnsemblGenome=PF14_0053|UniProtKB=Q8IM38	Ribonucleotide reductase small subunit	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00046	Oxidative stress response	P01132	c-jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	8837781	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00011	Blood coagulation	P00404	PAR-1	MOUSE|MGI=MGI=101802|UniProtKB=P30558	Proteinase-activated receptor 1	ISS	6978821	gi	PTHR24232:SF20	PROTEINASE-ACTIVATED RECEPTOR 1
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00636	FGFR1-4	BOVIN|Ensembl=ENSBTAG00000015457|UniProtKB=A4IFL5	Fibroblast growth factor receptor	ISS	9763444	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P00047	PDGF signaling pathway	P01148	Grb2	HUMAN|HGNC=4563|UniProtKB=O75791	GRB2-related adapter protein 2	ISS	10021361	PubMed	PTHR24418:SF299	GRB2-RELATED ADAPTER PROTEIN 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00048	PI3 kinase pathway	P01179	PKB	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	TAKRU|Ensembl=ENSTRUG00000007212|UniProtKB=H2SZB7	Serine/threonine-protein phosphatase	ISS	8392016	PubMed	PTHR11668:SF191	SERINE/THREONINE-PROTEIN PHOSPHATASE
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	IGI	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00050	Plasminogen activating cascade	P01252	MMP-1	BOVIN|Gene=MMP1|UniProtKB=P28053	Interstitial collagenase	ISS	95201294	PubMed	PTHR10201:SF151	INTERSTITIAL COLLAGENASE
P00057	Wnt signaling pathway	P01451	Galpha	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	TAS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	HUMAN|HGNC=12726|UniProtKB=P04275	von Willebrand factor	TAS	11583304	PubMed	PTHR11339:SF361	VON WILLEBRAND FACTOR-RELATED
P00006	Apoptosis signaling pathway	P00278	Bag	HUMAN|HGNC=939|UniProtKB=O95817	BAG family molecular chaperone regulator 3	ISS			PTHR12329:SF12	BAG FAMILY MOLECULAR CHAPERONE REGULATOR 3
P00057	Wnt signaling pathway	P01444	Wnt	CAEBR|Gene=CBG03422|UniProtKB=A8WV10	Protein CBR-CWN-2	ISS	8717036	PubMed	PTHR12027:SF77	PROTEIN WNT-5
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MACMU|Ensembl=ENSMMUG00000001661|UniProtKB=F7GR69	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P05916	Opioid prodynorphin pathway	P06001	AC	BOVIN|Ensembl=ENSBTAG00000019210|UniProtKB=F1MJV4	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00010	B cell activation	P00402	Jnk	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00029	Huntington disease	P00770	N-CoR	MOUSE|MGI=MGI=1349717|UniProtKB=Q60974	Nuclear receptor corepressor 1	IPI	10441327	PubMed	PTHR13992:SF5	NUCLEAR RECEPTOR COREPRESSOR 1
P00019	Endothelin signaling pathway	P00586	Gq	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00035	Interferon-gamma signaling pathway	P00956	SOCS	MOUSE|MGI=MGI=1924885|UniProtKB=Q9JLY0	Suppressor of cytokine signaling 6	TAS	15032587	PubMed	PTHR44562:SF1	SUPPRESSOR OF CYTOKINE SIGNALING 6
P02732	Coenzyme A linked carnitine metabolism	P02864	L-carnitine dehydratase	ECOLI|EcoGene=EG13284|UniProtKB=P76518	Acetyl-CoA:oxalate CoA-transferase	ISS			PTHR43949:SF1	ACETYL-COA:OXALATE COA-TRANSFERASE
P00029	Huntington disease	P00774	Dynein complex	NEUCR|EnsemblGenome=EFNCRG00000007044|UniProtKB=P45443	Dynein heavy chain, cytoplasmic	IPI	9454836	PubMed	PTHR10676:SF314	CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00006	Apoptosis signaling pathway	P00317	Fos	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MOUSE|MGI=MGI=1915339|UniProtKB=P59999	Actin-related protein 2/3 complex subunit 4	ISS	5031595	gi	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00056	VEGF signaling pathway	P01425	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00059	p53 pathway	P01480	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	CHICK|Ensembl=ENSGALG00000015835|UniProtKB=F1NZT2	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04585	TRH	DANRE|ZFIN=ZDB-GENE-040715-2|UniProtKB=Q6QX43	Glycoprotein hormones alpha chain	ISS			PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	CANLF|Ensembl=ENSCAFG00000010871|UniProtKB=F1PXA0	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P05731	GABA-B receptor II signaling	P05753	Ca channel	MOUSE|MGI=MGI=88296|UniProtKB=O55017	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	15079861	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00056	VEGF signaling pathway	P01411	Ras	CHICK|Ensembl=ENSGALG00000006885|UniProtKB=P08642	GTPase HRas	ISS	3035212	PubMed	PTHR24070:SF385	GTPASE HRAS
P00034	Integrin signalling pathway	P00938	Cdc42	XENTR|Xenbase=XB-GENE-967585|UniProtKB=Q28BZ0	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05914	Nicotine degradation	P05979	FMO3	RAT|RGD=619761|UniProtKB=Q9EQ76	Dimethylaniline monooxygenase [N-oxide-forming] 3	ISS			PTHR23023:SF44	DIMETHYLANILINE MONOOXYGENASE  N-OXIDE-FORMING  3
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00828	Galphai	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00048	PI3 kinase pathway	P01192	p110	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00050	Plasminogen activating cascade	P01254	pro-MMP-13	MOUSE|MGI=MGI=1340026|UniProtKB=P33435	Collagenase 3	ISS	91093077	PubMed	PTHR10201:SF165	COLLAGENASE 3
P00021	FGF signaling pathway	P00644	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02727	Androgen/estrogene/progesterone biosynthesis	P02826	Estradiol 17beta-dehydrogenase	MOUSE|MGI=MGI=105077|UniProtKB=P51656	Estradiol 17-beta-dehydrogenase 1	RCA			PTHR43391:SF15	ESTRADIOL 17-BETA-DEHYDROGENASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	CHICK|Ensembl=ENSGALG00000009927|UniProtKB=Q5ZHX1	Ras-related protein Rap-1b	ISS	1904317	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00057	Wnt signaling pathway	P01444	Wnt	CHICK|Ensembl=ENSGALG00000005401|UniProtKB=Q3L251	Protein Wnt	IDA	8717036	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00004	Alzheimer disease-presenilin pathway	P00163	Erb-B4 C-terminal fragment	MOUSE|MGI=MGI=104771|UniProtKB=Q61527	Receptor tyrosine-protein kinase erbB-4	ISS	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00034	Integrin signalling pathway	P00910	Grb2	MACMU|Ensembl=ENSMMUG00000005327|UniProtKB=F7GJG7	GRB2-related adapter protein	ISS	9741627	PubMed	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00006	Apoptosis signaling pathway	P00260	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	G01529	Proline oxidase	HUMAN|HGNC=9453|UniProtKB=O43272	Proline dehydrogenase 1, mitochondrial	RCA			PTHR13914:SF0	PROLINE DEHYDROGENASE 1, MITOCHONDRIAL
P00018	EGF receptor signaling pathway	P00562	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00046	Oxidative stress response	P01129	JNK1/2	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00053	T cell activation	P01330	IKK	MACMU|Ensembl=ENSMMUG00000008351|UniProtKB=F7HRV5	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00025	Hedgehog signaling pathway	P00682	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00770	N-CoR	RAT|RGD=1310293|UniProtKB=D3ZXN9	Nuclear receptor co-repressor 2 (Predicted), isoform CRA_a	ISS	11112321	PubMed	PTHR13992:SF21	NUCLEAR RECEPTOR COREPRESSOR 2
P00029	Huntington disease	P00790	beta-Tubulin	CANLF|Ensembl=ENSCAFG00000000443|UniProtKB=E2QSF4	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000018853|UniProtKB=F6XSK8	Uncharacterized protein	ISS	12441358	PubMed	PTHR24229:SF42	SOMATOSTATIN RECEPTOR TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	HUMAN|HGNC=8743|UniProtKB=P29120	Neuroendocrine convertase 1	IDA			PTHR42884:SF14	NEUROENDOCRINE CONVERTASE 1
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IC	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	MACMU|Ensembl=ENSMMUG00000010122|UniProtKB=F7HF84	Casein kinase I isoform epsilon	ISS	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	DROME|FlyBase=FBgn0019947|UniProtKB=O02194	Presenilin homolog	IDA	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	CHICK|Gene=TBP|UniProtKB=O13270	TATA-box-binding protein	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00628	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MACMU|Ensembl=ENSMMUG00000020037|UniProtKB=F7GDJ3	Anti-Muellerian hormone type-2 receptor	ISS	9759503	PubMed	PTHR23255:SF49	ANTI-MUELLERIAN HORMONE TYPE-2 RECEPTOR
P00036	Interleukin signaling pathway	P00973	PKB	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	TAS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-1712|UniProtKB=Q6PBY0	Guanine nucleotide binding protein (G protein), beta 5	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	CHICK|Gene=MYH3|UniProtKB=P02565	Myosin-1B	ISS	89264452	PubMed	PTHR13140:SF657	MYOSIN-4
P02777	Succinate to proprionate conversion	P03163	Methylmalonyl-CoA decarboxylase	HUMAN|HGNC=8654|UniProtKB=P05166	Propionyl-CoA carboxylase beta chain, mitochondrial	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P00034	Integrin signalling pathway	P00931	Integrin beta	CHICK|Ensembl=ENSGALG00000007511|UniProtKB=F1NM67	Integrin beta	IDA	3487386	PubMed	PTHR10082:SF15	INTEGRIN BETA-2
P00019	Endothelin signaling pathway	P00576	Pre-pro ET1-4	HUMAN|HGNC=3176|UniProtKB=P05305	Endothelin-1	ISS	15117818	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00037	Ionotropic glutamate receptor pathway	P01026	KA	RAT|RGD=2733|UniProtKB=P42260	Glutamate receptor ionotropic, kainate 2	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8971|UniProtKB=O00443	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00029	Huntington disease	P00807	Actin	TRIAD|EnsemblGenome=TriadG56111|UniProtKB=B3RX77	Non-muscle actin 6.2	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=2652894|UniProtKB=Q80Y86	Mitogen-activated protein kinase 15	ISS	9891064	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	IPI	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01444	Wnt	CHICK|Ensembl=ENSGALG00000005396|UniProtKB=Q2LMP1	Protein Wnt-3a	IDA	11266476	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000022175|UniProtKB=F6XHY0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01275	P38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	TAS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT1G59580|UniProtKB=Q39022	Mitogen-activated protein kinase 2	ISS	15218451	gi	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	DICDI|dictyBase=DDB_G0268622|UniProtKB=P34145	Rho-related protein rac1B	ISS			PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00006	Apoptosis signaling pathway	P00269	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01305	Calmodulin	MONDO|Ensembl=ENSMODG00000002696|UniProtKB=F7CY56	Uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF335	CALMODULIN, STRIATED MUSCLE
P00046	Oxidative stress response	P01138	MKK4	HUMAN|HGNC=6844|UniProtKB=P45985	Dual specificity mitogen-activated protein kinase kinase 4	TAS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MONDO|Ensembl=ENSMODG00000004799|UniProtKB=F6VM87	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00034	Integrin signalling pathway	P00941	Integrin alpha	MOUSE|MGI=MGI=96607|UniProtKB=P05555	Integrin alpha-M	IPI	3487386	PubMed	PTHR23220:SF120	INTEGRIN ALPHA-M
P00056	VEGF signaling pathway	P01417	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04633	P110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00216	Caspase 9	MACMU|Ensembl=ENSMMUG00000018163|UniProtKB=F7FNC1	Caspase	ISS	11440972	PubMed	PTHR10454:SF157	CASPASE-9
P00034	Integrin signalling pathway	P00944	Actin	RAT|RGD=1309504|UniProtKB=D3ZRN3	Protein Actbl2	ISS	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01390	TFIIA complex	HUMAN|HGNC=4646|UniProtKB=P52655	Transcription initiation factor IIA subunit 1	ISS	600519	OMIM	PTHR12694:SF7	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00024	Glycolysis	P00671	Phosphoglycerate kinase	MOUSE|MGI=MGI=97555|UniProtKB=P09411	Phosphoglycerate kinase 1	ISS	79199779	PubMed	PTHR11406:SF14	PHOSPHOGLYCERATE KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04397	p53 pathway by glucose deprivation	P04641	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00034	Integrin signalling pathway	P00932	FAK	RAT|RGD=628758|UniProtKB=P70600	Protein-tyrosine kinase 2-beta	IPI	12640026	PubMed	PTHR24418:SF94	PROTEIN-TYROSINE KINASE 2-BETA
P00013	Cell cycle	P00480	Proteasome	TRYB2|Gene=Tb927.8.570|UniProtKB=Q57YH3	Proteasome regulatory non-ATP-ase subunit 10	ISS	21975205	PubMed	PTHR10223:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	ARATH|TAIR=AT4G34460|UniProtKB=P49177	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF48	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	94280860	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00048	PI3 kinase pathway	P01177	P110ACT	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02741	Flavin biosynthesis	P02940	Riboflavin synthase	BACSU|EnsemblGenome=BSU23270|UniProtKB=P16440	Riboflavin synthase	ISS			PTHR21098:SF0	RIBOFLAVIN SYNTHASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05934	ELK1	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	9644975	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IDA	15572354	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00018	EGF receptor signaling pathway	P00550	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8051109	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	BOVIN|Ensembl=ENSBTAG00000014710|UniProtKB=P62833	Ras-related protein Rap-1A	ISS	8576107	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00018	EGF receptor signaling pathway	P00546	GAP	BOVIN|Ensembl=ENSBTAG00000005448|UniProtKB=F1N4Y6	Uncharacterized protein	ISS	6635197	gi	PTHR10194:SF4	RAS GTPASE-ACTIVATING PROTEIN 4-RELATED
P00045	Notch signaling pathway	P01110	Presenilin	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	ISS	12736250	PubMed	PTHR10202:SF18	PRESENILIN-1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00029	Huntington disease	P00790	beta-Tubulin	XENTR|Xenbase=XB-GENE-491459|UniProtKB=L7N3Q3	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00640	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00059	p53 pathway	P04623	CBP	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	RAT|RGD=628852|UniProtKB=Q02294	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	11976940	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00021	FGF signaling pathway	P00632	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00911	B-Raf	MOUSE|MGI=MGI=88190|UniProtKB=P28028	Serine/threonine-protein kinase B-raf	IDA	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P06664	Gonadotropin-releasing hormone receptor pathway	P06705	PLCbeta	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	RCA	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00053	T cell activation	P01312	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00021	FGF signaling pathway	P00627	ERK1-2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9836512	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00008	Axon guidance mediated by Slit/Robo	P00344	Netrin	DROME|FlyBase=FBgn0015773|UniProtKB=Q24567	Netrin-A	ISS			PTHR10574:SF365	NETRIN-1
P00048	PI3 kinase pathway	P01179	PKB	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00256	PLC-gamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MOUSE|MGI=MGI=2444552|UniProtKB=Q8BFZ3	Beta-actin-like protein 2	IC	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P02755	Methylmalonyl pathway	P03033	Propionyl-CoA carboxylase	DICDI|dictyBase=DDB_G0276341|UniProtKB=Q8T131	Uncharacterized protein	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	RCA	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	ISS	97320448	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00056	VEGF signaling pathway	P01407	Erk	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	MOUSE|MGI=MGI=94927|UniProtKB=Q8BLD9	D(1B) dopamine receptor	ISS	9700720	PubMed	PTHR43893:SF8	D 1B  DOPAMINE RECEPTOR
P00034	Integrin signalling pathway	P00931	Integrin beta	HUMAN|HGNC=6153|UniProtKB=P05556	Integrin beta-1	IDA	10706722	PubMed	PTHR10082:SF28	INTEGRIN BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MACMU|Ensembl=ENSMMUG00000010392|UniProtKB=F7ASR8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	IC	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05916	Opioid prodynorphin pathway	P06002	G-protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00238	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00046	Oxidative stress response	P01135	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P02723	Adenine and hypoxanthine salvage pathway	P02804	Hypoxanthine phosphoribosyl transferase	RAT|RGD=1310177|UniProtKB=B2RYS6	Phosphoribosyl transferase domain containing 1	ISS			PTHR43340:SF5	PHOSPHORIBOSYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	DANRE|ZFIN=ZDB-GENE-020125-5|UniProtKB=A2CG69	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF356	SUBFAMILY NOT NAMED
P00029	Huntington disease	G01535	PIG3	HUMAN|HGNC=19373|UniProtKB=Q53FA7	Quinone oxidoreductase PIG3	TAS	12932731	PubMed	PTHR43006:SF2	QUINONE OXIDOREDUCTASE PIG3
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DANRE|ZFIN=ZDB-GENE-040426-2427|UniProtKB=F1Q6C0	Uncharacterized protein (Fragment)	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00632	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ORNAN|Ensembl=ENSOANG00000000460|UniProtKB=F7F4W9	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00012	Cadherin signaling pathway	P00463	betacatenin	MONDO|Ensembl=ENSMODG00000011192|UniProtKB=F6SRK5	Uncharacterized protein	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P04393	Ras Pathway	P04572	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00034	Integrin signalling pathway	P00951	Jnk	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	IDA	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	CAEEL|WormBase=WBGene00001985|UniProtKB=O02100	Presenilin hop-1	TAS	98004548	PubMed	PTHR10202:SF14	PRESENILIN HOP-1
P00059	p53 pathway	P04623	CBP	ARATH|TAIR=AT1G16710|UniProtKB=Q9FWQ5	Histone acetyltransferase HAC12	ISS	8413673	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	IC	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00807	Actin	HUMAN|HGNC=143|UniProtKB=P68032	Actin, alpha cardiac muscle 1	IDA	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MOUSE|MGI=MGI=1346338|UniProtKB=Q9R0M1	Chemokine XC receptor 1	IC			PTHR10489:SF730	CHEMOKINE XC RECEPTOR 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95777|UniProtKB=Q6R0H7	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas	IC	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00005	Angiogenesis	P00183	Shc	MOUSE|MGI=MGI=98296|UniProtKB=P98083	SHC-transforming protein 1	ISS	7798194	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	DROME|FlyBase=FBgn0261397|UniProtKB=A1Z6Z8	Dilute class unconventional myosin, isoform C	IC			PTHR13140:SF725	DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02918	dUTP pyrophosphatase	CHICK|Ensembl=ENSGALG00000004954|UniProtKB=Q5ZKJ3	Uncharacterized protein	ISS			PTHR11241:SF0	BCDNA.LD08534
P00053	T cell activation	P01330	IKK	HUMAN|HGNC=1974|UniProtKB=O15111	Inhibitor of nuclear factor kappa-B kinase subunit alpha	IGI	12235208	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95814|UniProtKB=Q60934	Glutamate receptor ionotropic, kainate 1	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	HUMAN|HGNC=6267|UniProtKB=P48051	G protein-activated inward rectifier potassium channel 2	IDA	2433589	PubMed	PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00036	Interleukin signaling pathway	P00996	STAT	MONDO|Ensembl=ENSMODG00000014816|UniProtKB=F7CHH2	Signal transducer and activator of transcription	ISS	96102059	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00005	Angiogenesis	P00189	Fzd	PANTR|Ensembl=ENSPTRG00000009279|UniProtKB=H2QD74	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF34	FRIZZLED-2
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00059	p53 pathway	P04609	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04393	Ras Pathway	P04550	Ral	HUMAN|HGNC=9840|UniProtKB=P11234	Ras-related protein Ral-B	ISS	7687439	PubMed	PTHR24070:SF199	RAS-RELATED PROTEIN RAL-B
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04393	Ras Pathway	P04556	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IDA	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00010	B cell activation	P00375	Calmodulin	CANLF|Ensembl=ENSCAFG00000030049|UniProtKB=J9NWQ5	Uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF311	CALMODULIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02727	Androgen/estrogene/progesterone biosynthesis	P02829	Cholesterol acyltransferase	MACMU|Ensembl=ENSMMUG00000003768|UniProtKB=F7GXC5	O-acyltransferase	ISS	11948213	PubMed	PTHR10408:SF6	STEROL O-ACYLTRANSFERASE 1
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IGI	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04398	p53 pathway feedback loops 2	P04661	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04395	Vasopressin synthesis	P04590	Vasopressin	DANRE|ZFIN=ZDB-GENE-030407-1|UniProtKB=F1QC27	Uncharacterized protein	ISS			PTHR11681:SF14	SUBFAMILY NOT NAMED
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00024	Glycolysis	P00674	Phosphoglucose isomerase	STRCO|EnsemblGenome=CAB38132|UniProtKB=Q9Z523	Glucose-6-phosphate isomerase 2	ISS	21996410	PubMed	PTHR11469:SF1	GLUCOSE-6-PHOSPHATE ISOMERASE, CYTOSOLIC
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	10693759	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MACMU|Ensembl=ENSMMUG00000009341|UniProtKB=F6UA54	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00010	B cell activation	P00402	Jnk	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02757	O-antigen biosynthesis	P03050	dTDP-4-dehydrorhamnose reductase	MOUSE|MGI=MGI=1913667|UniProtKB=Q99LB6	Methionine adenosyltransferase 2 subunit beta	ISS			PTHR10491:SF4	METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00057	Wnt signaling pathway	P01471	alpha-catenin	MACMU|Ensembl=ENSMMUG00000017985|UniProtKB=F7DN31	Uncharacterized protein	ISS	1768802	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	15531926	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01390	TFIIA complex	CAEEL|WormBase=WBGene00013736|UniProtKB=Q9NEX2	Transcription initiation factor IIA subunit 2	ISS			PTHR10966:SF0	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	STRPU|EnsemblGenome=SPU_018419|UniProtKB=W4YRI6	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00029	Huntington disease	P00786	ARF	TAKRU|Ensembl=ENSTRUG00000014380|UniProtKB=H2UIJ6	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF299	ADP-RIBOSYLATION FACTOR 2
P04393	Ras Pathway	P04572	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000009085|UniProtKB=H2RDQ2	Uncharacterized protein	ISS	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00012	Cadherin signaling pathway	P00462	Casein kinase II	MONDO|Ensembl=ENSMODG00000019523|UniProtKB=F6VCI6	Uncharacterized protein	ISS	10617630	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	TAKRU|Ensembl=ENSTRUG00000000002|UniProtKB=H2RIN9	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF236	SUBFAMILY NOT NAMED
P00053	T cell activation	P01305	Calmodulin	STRPU|EnsemblGenome=SPU_005033|UniProtKB=W4XNQ0	Uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF263	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00045	Notch signaling pathway	P01101	Su(H)	CANLF|Ensembl=ENSCAFG00000016387|UniProtKB=E2QV83	Uncharacterized protein	ISS	8406481	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00010	B cell activation	P00376	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DANRE|ZFIN=ZDB-GENE-040426-2427|UniProtKB=F1Q6C0	Uncharacterized protein (Fragment)	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P02721	ATP synthesis	P02798	Cyt C	DANRE|Ensembl=ENSDARG00000044562|UniProtKB=Q6IQM2	Cytochrome c	ISS	4358609	PubMed	PTHR11961:SF12	CYTOCHROME C
P00056	VEGF signaling pathway	P01408	Akt/PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	DROME|FlyBase=FBgn0032859|UniProtKB=Q9VIM5	Actin-related protein 2/3 complex subunit 2	ISS	12473693	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04393	Ras Pathway	P04546	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	DICDI|dictyBase=DDB_G0277221|UniProtKB=P25870	Clathrin heavy chain	IDA	9388255	PubMed	PTHR10292:SF1	CLATHRIN HEAVY CHAIN
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000003497|UniProtKB=F7E6Z1	Uncharacterized protein	ISS	8120095	PubMed	PTHR24026:SF37	PROTOCADHERIN FAT 2
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=8155|UniProtKB=P41146	Nociceptin receptor	IDA	11259498	PubMed	PTHR24229:SF11	NOCICEPTIN RECEPTOR
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=19663|UniProtKB=Q9UBI6	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00018	EGF receptor signaling pathway	P00560	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	GIAIC|EnsemblGenome=GL50803_11214|UniProtKB=E2RTP0	Kinase, AGC PKA	ISS			PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000005903|UniProtKB=F1N1K8	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00049	Parkinson disease	P01208	Hsp70	DANRE|ZFIN=ZDB-GENE-031001-11|UniProtKB=Q6P3L3	Heat shock protein 5	ISS	10934466	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P06664	Gonadotropin-releasing hormone receptor pathway	P06794	MAP2K1/2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	RCA	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P02746	Heme biosynthesis	P02975	Uroporphyrinogen decarboxylase	MACMU|Ensembl=ENSMMUG00000016623|UniProtKB=F7HR87	Uroporphyrinogen decarboxylase	ISS			PTHR21091:SF2	UROPORPHYRINOGEN DECARBOXYLASE
P00034	Integrin signalling pathway	P00926	GRAF	PANTR|Ensembl=ENSPTRG00000016497|UniProtKB=H2QQ97	Uncharacterized protein	ISS	8649427	PubMed	PTHR12552:SF5	RHO GTPASE-ACTIVATING PROTEIN 10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	RAT|RGD=2201|UniProtKB=P25023	B2 bradykinin receptor	IDA	12130679	PubMed	PTHR24228:SF25	B2 BRADYKININ RECEPTOR
P00036	Interleukin signaling pathway	P00975	RasGAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	ISS	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	RAT|RGD=620739|UniProtKB=F1M798	Metalloendopeptidase	ISS	9759503	PubMed	PTHR43978:SF3	BONE MORPHOGENETIC PROTEIN 1
P02781	Threonine biosynthesis	P03190	Threonine synthase	BACSU|EnsemblGenome=BSU32250|UniProtKB=P04990	Threonine synthase	ISS			PTHR10314:SF5	THREONINE SYNTHASE 1, CHLOROPLASTIC
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00057	Wnt signaling pathway	P01457	GBeta	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00035	Interferon-gamma signaling pathway	P00960	PTP	CANLF|Ensembl=ENSCAFG00000008894|UniProtKB=F1Q3J6	Tyrosine-protein phosphatase non-receptor type	ISS	1382983	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IC	2837282	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-070112-342|UniProtKB=A1L271	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04393	Ras Pathway	P04543	MEKK1/4	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS	12878610	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P04385	Histamine H1 receptor mediated signaling pathway	P04485	H1	MACMU|Ensembl=ENSMMUG00000004817|UniProtKB=F6QJP0	Histamine H1 receptor	ISS	11841575	PubMed	PTHR43914:SF2	HISTAMINE H1 RECEPTOR
P00018	EGF receptor signaling pathway	P00559	MEK1-2	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	HUMAN|HGNC=6856|UniProtKB=Q9Y6R4	Mitogen-activated protein kinase kinase kinase 4	IGI	12052864	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00056	VEGF signaling pathway	P01407	Erk	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00586	Gq	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	CAEBR|Gene=CBG10434|UniProtKB=A8XB74	Cysteine synthase	ISS			PTHR10314:SF71	CYSTEINE SYNTHASE-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00048	PI3 kinase pathway	P01206	14-3-3	ORNAN|Ensembl=ENSOANG00000007305|UniProtKB=F6XW91	Uncharacterized protein	ISS	12865427	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00004	Alzheimer disease-presenilin pathway	P00114	actin	STRPU|EnsemblGenome=SPU_006797|UniProtKB=W4XTP5	Uncharacterized protein	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	88241036	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00006	Apoptosis signaling pathway	P00308	Mcl1	HUMAN|HGNC=6943|UniProtKB=Q07820	Induced myeloid leukemia cell differentiation protein Mcl-1	IDA	11877256	PubMed	PTHR11256:SF46	INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN MCL-1
P00059	p53 pathway	P04633	P110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00021	FGF signaling pathway	P00632	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04567	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IDA	12660731	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	IC	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	THEMA|EnsemblGenome=TM_0665|UniProtKB=Q9WZD3	Cysteine synthase	ISS			PTHR10314:SF159	CYSTEINE SYNTHASE A
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	IDA	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	PANTR|Ensembl=ENSPTRG00000012813|UniProtKB=H2QJ90	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF31	FRIZZLED-7
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CAEEL|WormBase=WBGene00006932|UniProtKB=Q9TXI7	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MACMU|Ensembl=ENSMMUG00000019112|UniProtKB=F6T8S6	N-methyl D-aspartate receptor subtype 2B	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04393	Ras Pathway	P04541	p90RSK	MOUSE|MGI=MGI=104558|UniProtKB=P18653	Ribosomal protein S6 kinase alpha-1	IDA	6755374	gi	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	HUMAN|HGNC=5295|UniProtKB=P28335	5-hydroxytryptamine receptor 2C	ISS	12441358	PubMed	PTHR24247:SF32	5-HYDROXYTRYPTAMINE RECEPTOR 2C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	DANRE|ZFIN=ZDB-GENE-060824-1|UniProtKB=C3PTE8	Beta-arrestin 1	ISS	4757780	gi	PTHR11792:SF22	BETA-ARRESTIN-1
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	DROME|FlyBase=FBgn0032002|UniProtKB=Q9VLR2	CG8353, isoform A	ISS			PTHR11644:SF2	CYTIDINE DEAMINASE
P00012	Cadherin signaling pathway	P00470	F-actin	ORNAN|Ensembl=ENSOANG00000007716|UniProtKB=F6UDX9	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	THEMA|EnsemblGenome=TM_0148|UniProtKB=Q9WXZ5	Glutamine--fructose-6-phosphate aminotransferase [isomerizing]	ISS			PTHR10937:SF0	GH12731P-RELATED
P00019	Endothelin signaling pathway	P00580	ET-RA/B	CANLF|Gene=EDNRA|UniProtKB=Q5KSU9	Endothelin-1 receptor	ISS	91195317	PubMed	PTHR24243:SF31	ENDOTHELIN-1 RECEPTOR
P00057	Wnt signaling pathway	P01447	Dishevelled	CAEEL|WormBase=WBGene00003241|UniProtKB=Q22227	Uncharacterized protein	ISS	7906389	PubMed	PTHR10878:SF24	SUBFAMILY NOT NAMED
P05918	p38 MAPK pathway	P06034	MKK4	HUMAN|HGNC=6844|UniProtKB=P45985	Dual specificity mitogen-activated protein kinase kinase 4	IDA	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00006	Apoptosis signaling pathway	P00292	IkappaB	BOVIN|Ensembl=ENSBTAG00000016683|UniProtKB=Q8WNW7	NF kappa B inhibitor alpha (Fragment)	ISS	10811867	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00036	Interleukin signaling pathway	P00973	PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01181	GSK3	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00036	Interleukin signaling pathway	P00981	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00019	Endothelin signaling pathway	P00570	PKA	DICDI|dictyBase=DDB_G0279413|UniProtKB=P05987	cAMP-dependent protein kinase regulatory subunit	IGI	91072385	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P02757	O-antigen biosynthesis	P03050	dTDP-4-dehydrorhamnose reductase	BACSU|EnsemblGenome=BSU37820|UniProtKB=P39631	Spore coat polysaccharide biosynthesis protein SpsK	ISS			PTHR10491:SF4	METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	TAS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00012	Cadherin signaling pathway	P00474	Wnt	MONDO|Ensembl=ENSMODG00000015364|UniProtKB=F6WHM2	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008422|UniProtKB=F6VUT7	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00636	FGFR1-4	MOUSE|MGI=MGI=95525|UniProtKB=Q03142	Fibroblast growth factor receptor 4	IGI	12466116	PubMed	PTHR24416:SF343	FIBROBLAST GROWTH FACTOR RECEPTOR 4
P00019	Endothelin signaling pathway	P00591	PLCbeta	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	CANLF|Ensembl=ENSCAFG00000019633|UniProtKB=F1PDC7	Uncharacterized protein	ISS	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01411	Ras	PANTR|Ensembl=ENSPTRG00000034469|UniProtKB=H2Q2V0	Uncharacterized protein	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00048	PI3 kinase pathway	P01188	Gbetagamma	CAEEL|WormBase=WBGene00001680|UniProtKB=Q20636	Guanine nucleotide-binding protein subunit beta-2	IGI	9754712	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04384	Gamma-aminobutyric acid synthesis	P04481	Succinic semialdehyde dehydrogenase	NEUCR|Gene=NCU00936|UniProtKB=V5IQD0	Succinate semialdehyde dehydrogenase	IC	12891648	PubMed	PTHR43353:SF5	SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02763	Peptidoglycan biosynthesis	P03084	UDP-N-acetylmuramoylalanyl-D-glutamate 2,6-diaminopimelate ligase	BACSU|EnsemblGenome=BSU15180|UniProtKB=Q03523	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase	ISS			PTHR23135:SF4	UDP-N-ACETYLMUAMOYLALANYL-D-GLUTAMATE-2,6-DIAMINOPIMELATE LIGASE-RELATED
P00012	Cadherin signaling pathway	P00471	Cadherin	CHICK|Ensembl=ENSGALG00000012941|UniProtKB=E1C235	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF96	CADHERIN-12
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	THEMA|EnsemblGenome=TM_1875|UniProtKB=Q9X2I8	Glutamate--tRNA ligase 2	ISS			PTHR43311:SF2	GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02726	Aminobutyrate degradation	P02825	4-aminobutyrate aminotransferase	BOVIN|Gene=ABAT|UniProtKB=Q9BGI0	4-aminobutyrate aminotransferase, mitochondrial	ISS	2496985	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P04397	p53 pathway by glucose deprivation	P04636	S6K	HUMAN|HGNC=10437|UniProtKB=Q9UBS0	Ribosomal protein S6 kinase beta-2	IDA	15116068	PubMed	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P04398	p53 pathway feedback loops 2	P04665	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	TAKRU|Ensembl=ENSTRUG00000008685|UniProtKB=H2TXN3	Uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF326	CALMODULIN
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=1351344|UniProtKB=Q68ED2	Metabotropic glutamate receptor 7	ISS	12488551	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00034	Integrin signalling pathway	P00924	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01375	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00034	Integrin signalling pathway	P00925	MEK	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00034	Integrin signalling pathway	P00951	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000015241|UniProtKB=Q5IS72	D(3) dopamine receptor	ISS	2137198	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00049	Parkinson disease	P01227	20S proteasome	CAEEL|WormBase=WBGene00003948|UniProtKB=O62102	Proteasome subunit beta type	TAS	12859888	PubMed	PTHR11599:SF44	AT05866P-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	RAT|RGD=2348|UniProtKB=Q05941	Neuronal acetylcholine receptor subunit alpha-7	ISS	11404397	PubMed	PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MOUSE|MGI=MGI=109246|UniProtKB=P97288	5-hydroxytryptamine receptor 4	IDA	12441358	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01084	CHT1	RAT|RGD=69270|UniProtKB=Q9JMD7	High affinity choline transporter 1	RCA			PTHR11819:SF129	HIGH AFFINITY CHOLINE TRANSPORTER 1
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	ANOGA|EnsemblGenome=AGAP006475|UniProtKB=Q5TQX0	AGAP006475-PA	IDA	12880387	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00004	Alzheimer disease-presenilin pathway	P00168	E-cadherin intracellular fragment	RAT|RGD=621089|UniProtKB=F1LMI3	Cadherin 3, type 1, P-cadherin (Placental)	ISS	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P00018	EGF receptor signaling pathway	P00549	EGF	MOUSE|MGI=MGI=107508|UniProtKB=Q61521	Proepiregulin	ISS			PTHR10740:SF11	PROEPIREGULIN
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00029	Huntington disease	P00775	Rac	MACMU|Ensembl=ENSMMUG00000021075|UniProtKB=F7GY91	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	ISS	15313841	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MOUSE|MGI=MGI=1927498|UniProtKB=Q99PG4	Regulator of G-protein signaling 18	IDA	11563974	PubMed	PTHR10845:SF155	REGULATOR OF G-PROTEIN SIGNALING 18
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	DANRE|ZFIN=ZDB-GENE-020503-1|UniProtKB=Q1LWJ4	Tyrosine-protein kinase receptor	ISS	249616	gi	PTHR24416:SF498	TYROSINE-PROTEIN KINASE RECEPTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P06959	CCKR signaling map	P07225	RAC1-GDP	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	RCA	19940064	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04393	Ras Pathway	P04557	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00030	Hypoxia response via HIF activation	P00824	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00035	Interferon-gamma signaling pathway	P00953	Jak1	BOVIN|Ensembl=ENSBTAG00000003147|UniProtKB=F1N0D6	Tyrosine-protein kinase	ISS	9637709	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P05918	p38 MAPK pathway	P06018	MNK1	HUMAN|HGNC=7110|UniProtKB=Q9BUB5	MAP kinase-interacting serine/threonine-protein kinase 1	IDA	9155018	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CHICK|Gene=MYH3|UniProtKB=P02565	Myosin-1B	IC	89264452	PubMed	PTHR13140:SF657	MYOSIN-4
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Ensembl=ENSPTRG00000011042|UniProtKB=H2QGF5	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00059	p53 pathway	P04609	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MOUSE|MGI=MGI=102705|UniProtKB=P63213	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00012	Cadherin signaling pathway	P00470	F-actin	XENTR|Xenbase=XB-GENE-493937|UniProtKB=Q5M8T9	Actin, alpha 2, smooth muscle, aorta	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00021	FGF signaling pathway	P00633	Ras	DICDI|dictyBase=DDB_G0292998|UniProtKB=P32252	Ras-like protein rasB	ISS	7997267	PubMed	PTHR24070:SF206	RAS-LIKE PROTEIN RASB
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	BOVIN|Ensembl=ENSBTAG00000026481|UniProtKB=G3MX08	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF147	REGULATOR OF G-PROTEIN SIGNALING 8
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00780	Microtubule	PRIPA|Gene=PPA21758|UniProtKB=H3FHL1	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF89	TUBULIN BETA-4 CHAIN
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g169611|UniProtKB=A7SEB1	Predicted protein	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00004	Alzheimer disease-presenilin pathway	P00114	actin	RAT|RGD=1310826|UniProtKB=Q5M7U6	Actin-related protein 2	ISS	11889126	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	IDA	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00005	Angiogenesis	P00190	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00269	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	RAT|RGD=61862|UniProtKB=P19491	Glutamate receptor 2	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00059	p53 pathway	P04630	PP2A	BOVIN|Ensembl=ENSBTAG00000009245|UniProtKB=Q0P594	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00005	Angiogenesis	P00209	FAK	MONDO|Ensembl=ENSMODG00000000707|UniProtKB=F6WLE6	Uncharacterized protein	ISS	12640026	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00023	General transcription regulation	P00668	TFIIB	MACMU|Ensembl=ENSMMUG00000002794|UniProtKB=F7H232	Transcription initiation factor IIB	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	8687401	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00005	Angiogenesis	P00221	JNK1	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	ISS	10851062	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	BOVIN|Ensembl=ENSBTAG00000034883|UniProtKB=A6QLA5	CCR4 protein	ISS	12009564	PubMed	PTHR10489:SF608	C-C CHEMOKINE RECEPTOR TYPE 4
P06664	Gonadotropin-releasing hormone receptor pathway	P06850	PKCs(3)	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01444	Wnt	XENTR|Xenbase=XB-GENE-960148|UniProtKB=F6XMD3	Protein Wnt (Fragment)	ISS	11266476	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00048	PI3 kinase pathway	P01194	S6K	PANTR|Ensembl=ENSPTRG00000003957|UniProtKB=H2Q486	Ribosomal protein S6 kinase	ISS	15116068	PubMed	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=1930705|UniProtKB=P61264	Syntaxin-1B	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00045	Notch signaling pathway	P01113	Pen-2	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	ISS	12885769	PubMed	PTHR10202:SF13	PRESENILIN-2
P00046	Oxidative stress response	P01129	JNK1/2	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00012	Cadherin signaling pathway	P00471	Cadherin	DROME|FlyBase=FBgn0000497|UniProtKB=Q24292	Protein dachsous	IDA	8120095	PubMed	PTHR24026:SF54	PROTEIN DACHSOUS
P00049	Parkinson disease	P01220	Ubc7	ANOGA|EnsemblGenome=AGAP002169|UniProtKB=Q7QK63	AGAP002169-PA	ISS	12859888	PubMed	PTHR24067:SF154	UBIQUITIN-CONJUGATING ENZYME E2 G2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	DANRE|ZFIN=ZDB-GENE-010705-1|UniProtKB=Q90Z40	Guanine nucleotide-binding protein subunit gamma	IDA	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00019	Endothelin signaling pathway	P00566	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	CANLF|Ensembl=ENSCAFG00000013102|UniProtKB=Q8HZM5	Glutamine synthetase	ISS			PTHR20852:SF45	GLUTAMINE SYNTHETASE
P00017	DNA replication	P00527	Histones	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g194445|UniProtKB=A7SX94	Histone H3	ISS	12413958	PubMed	PTHR11426:SF169	HISTONE H3
P00018	EGF receptor signaling pathway	P00551	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	12655147	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_56698|UniProtKB=C3XYC3	Putative uncharacterized protein	IDA	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00054	Toll receptor signaling pathway	G01550	Gene trancription	DANRE|ZFIN=ZDB-GENE-020530-2|UniProtKB=Q6P4V3	Prostaglandin-endoperoxide synthase 2a	ISS	12011329	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	DROME|FlyBase=FBgn0038491|UniProtKB=Q9VEM0	CG5292, isoform A	ISS			PTHR11079:SF92	TRNA-SPECIFIC ADENOSINE DEAMINASE 2
P00006	Apoptosis signaling pathway	P00313	IKK	BOVIN|Ensembl=ENSBTAG00000007599|UniProtKB=Q95KV0	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00057	Wnt signaling pathway	P01428	Frizzled	PANTR|Ensembl=ENSPTRG00000020122|UniProtKB=H2QVZ0	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF22	FRIZZLED-3
P00010	B cell activation	P00397	IKK	PANTR|Ensembl=ENSPTRG00000020202|UniProtKB=H2QW34	Uncharacterized protein	ISS	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014262|UniProtKB=F7BYS8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00036	Interleukin signaling pathway	P00996	STAT	CANLF|Ensembl=ENSCAFG00000015213|UniProtKB=E2RB82	Signal transducer and activator of transcription	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00019	Endothelin signaling pathway	P00589	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00046	Oxidative stress response	P01135	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	CHICK|Ensembl=ENSGALG00000005198|UniProtKB=F1P4J0	Ribosomal protein S6 kinase	ISS	15116068	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	CANLF|Ensembl=ENSCAFG00000017589|UniProtKB=F1PKX6	Uncharacterized protein	ISS	9783586	PubMed	PTHR10814:SF24	TRANSDUCIN-LIKE ENHANCER PROTEIN 3
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	CANLF|Ensembl=ENSCAFG00000009282|UniProtKB=E2RLD6	Uncharacterized protein	ISS	608972	OMIM	PTHR22952:SF24	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 1
P00057	Wnt signaling pathway	P01455	Smad4	MONDO|Ensembl=ENSMODG00000000500|UniProtKB=F6TU68	Mothers against decapentaplegic homolog	ISS	12736218	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IDA	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04398	p53 pathway feedback loops 2	P04665	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MOUSE|MGI=MGI=2661081|UniProtKB=Q8K348	Activin receptor type-1C	ISS	10683140	PubMed	PTHR23255:SF58	ACTIVIN RECEPTOR TYPE-1C
P05918	p38 MAPK pathway	P06044	GADD45	MONDO|Ensembl=ENSMODG00000000788|UniProtKB=F6SSE6	Uncharacterized protein	ISS	9827804	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	DEIRA|EnsemblGenome=DR_B0108|UniProtKB=Q9RZL7	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT ALPHA
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	PANTR|Ensembl=ENSPTRG00000014711|UniProtKB=H2QZF5	TGF-beta receptor type-2	ISS	9395284	PubMed	PTHR23255:SF55	TGF-BETA RECEPTOR TYPE-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PRIPA|Gene=PPA17339|UniProtKB=H3F5B4	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF352	ACTIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00059	p53 pathway	P04634	Cdc2	ORYSJ|EnsemblGenome=OS02G0123100|UniProtKB=P29619	Cyclin-dependent kinase A-2	ISS			PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P02723	Adenine and hypoxanthine salvage pathway	P02804	Hypoxanthine phosphoribosyl transferase	AQUAE|EnsemblGenome=aq_544|UniProtKB=O66821	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	ARATH|TAIR=AT4G28860|UniProtKB=Q8LPI7	Protein CASEIN KINASE I-LIKE 4	ISS	11437445	PubMed	PTHR11909:SF97	PROTEIN CASEIN KINASE I-LIKE 3-RELATED
P00025	Hedgehog signaling pathway	P00691	CBP	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	XENTR|Xenbase=XB-GENE-1005779|UniProtKB=F7E3I6	Uncharacterized protein	ISS	2137198	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00508	Cofilin	HUMAN|HGNC=1874|UniProtKB=P23528	Cofilin-1	ISS			PTHR11913:SF17	COFILIN-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	CANLF|Ensembl=ENSCAFG00000009812|UniProtKB=E2RIA0	Uncharacterized protein	ISS	12374786	PubMed	PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MACMU|Ensembl=ENSMMUG00000010380|UniProtKB=F7D9M6	Uncharacterized protein	ISS	9874775	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05913	Enkephalin release	P05977	G-Protein (s)	DAPPU|EnsemblGenome=DAPPUDRAFT_206575|UniProtKB=E9FUX0	Guanine nucleotide binding protein, beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00049	Parkinson disease	P01236	Casein kinase II	BRAFL|Gene=BRAFLDRAFT_113587|UniProtKB=C3ZBE3	Putative uncharacterized protein	ISS	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	RCA	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00006	Apoptosis signaling pathway	P00267	MADD	CANLF|Ensembl=ENSCAFG00000008656|UniProtKB=E2QTJ4	Uncharacterized protein	ISS	9115275	PubMed	PTHR13008:SF7	MAP KINASE-ACTIVATING DEATH DOMAIN PROTEIN
P00059	p53 pathway	P01480	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04393	Ras Pathway	P04558	p38	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02783	Tryptophan biosynthesis	P03209	Anthranilate phosphoribosyl transferase	FUSNN|EnsemblGenome=FN1731|UniProtKB=Q8RI82	Anthranilate synthase component II	ISS			PTHR43418:SF4	MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN
P05918	p38 MAPK pathway	P06031	p38alpha	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	RCA	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01448	CBP	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	IDA	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	BOVIN|Ensembl=ENSBTAG00000010191|UniProtKB=Q08E52	Serine/threonine-protein kinase PAK 1	ISS	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00022	General transcription by RNA polymerase I	P00652	RNA Polymerase I  Complex	XENTR|Xenbase=XB-GENE-1008539|UniProtKB=F6ZV36	DNA-directed RNA polymerase subunit beta	ISS	15691654	PubMed	PTHR20856:SF5	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g188243|UniProtKB=A7SCN8	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	ANOGA|EnsemblGenome=AGAP002971|UniProtKB=Q7PQY4	AGAP002971-PA	ISS			PTHR18945:SF505	ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02763	Peptidoglycan biosynthesis	P03090	N-Acetylglucosaminyl transferase	GLOVI|EnsemblGenome=BAC89612|UniProtKB=Q7MBC4	UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase	ISS			PTHR21015:SF22	GLYCOSYLTRANSFERASE
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	HUMAN|HGNC=4579|UniProtKB=P39086	Glutamate receptor ionotropic, kainate 1	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P02738	De novo purine biosynthesis	P02899	GMP synthase	SYNY3|EnsemblGenome=BAA10210|UniProtKB=P49057	GMP synthase [glutamine-hydrolyzing]	ISS			PTHR11922:SF2	GMP SYNTHASE  GLUTAMINE-HYDROLYZING
P04393	Ras Pathway	P04565	MKK4/7	MOUSE|MGI=MGI=1346869|UniProtKB=P47809	Dual specificity mitogen-activated protein kinase kinase 4	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00021	FGF signaling pathway	P00642	MEK1-2	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IGI	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02783	Tryptophan biosynthesis	P03206	Anthranilate synthase	STRCO|EnsemblGenome=CAB38585|UniProtKB=Q9Z4W7	Anthranilate synthase component 1	ISS			PTHR11236:SF9	ANTHRANILATE SYNTHASE COMPONENT 1
P00019	Endothelin signaling pathway	P00566	ERK	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P04393	Ras Pathway	P04570	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IDA	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00938	Cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00048	PI3 kinase pathway	P01188	Gbetagamma	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	6264430	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00021	FGF signaling pathway	P00627	ERK1-2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00056	VEGF signaling pathway	P01414	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04380	Cortocotropin releasing factor receptor signaling pathway	G04671	proopiomelanocortin	RAT|RGD=3366|UniProtKB=P01194	Pro-opiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CHICK|Gene=ACTG2|UniProtKB=P63270	Actin, gamma-enteric smooth muscle	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=11433|UniProtKB=Q16623	Syntaxin-1A	ISS	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MOUSE|MGI=MGI=95821|UniProtKB=Q01097	Glutamate receptor ionotropic, NMDA 2B	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00021	FGF signaling pathway	P00624	14-3-3	XENTR|Xenbase=XB-GENE-970616|UniProtKB=Q6P4Z5	14-3-3 protein zeta	ISS	12615066	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00057	Wnt signaling pathway	P01451	Galpha	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	IDA	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	TAS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01182	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P02747	Histidine biosynthesis	P02985	Histidinol dehydrogenase	NEUCR|EnsemblGenome=EFNCRG00000002822|UniProtKB=P07685	Histidine biosynthesis trifunctional protein	ISS			PTHR21256:SF2	HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00013	Cell cycle	P00480	Proteasome	XENTR|Xenbase=XB-GENE-981879|UniProtKB=F6V8H8	Uncharacterized protein	ISS	9218537	PubMed	PTHR10660:SF4	PROTEASOME ACTIVATOR COMPLEX SUBUNIT 3
P02740	De novo pyrimidine ribonucleotides biosythesis	P02922	Orotate phosphoribosyltransferase	HALSA|EnsemblGenome=VNG_2118G|UniProtKB=Q9HNG2	Orotate phosphoribosyltransferase	ISS			PTHR19278:SF49	SUBFAMILY NOT NAMED
P00015	Circadian clock system	G01504	bmal1	HUMAN|HGNC=701|UniProtKB=O00327	Aryl hydrocarbon receptor nuclear translocator-like protein 1	IDA	11163178	PubMed	PTHR23042:SF52	ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 1
P00048	PI3 kinase pathway	P01177	P110ACT	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	IC	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00052	TGF-beta signaling pathway	P01290	TAB	PANTR|Ensembl=ENSPTRG00000014395|UniProtKB=H2QLQ4	Uncharacterized protein	ISS	8638164	PubMed	PTHR13832:SF533	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	MACMU|Ensembl=ENSMMUG00000012005|UniProtKB=F7H091	Metabotropic glutamate receptor 2 isoform a	ISS	9407094	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00052	TGF-beta signaling pathway	P01288	FKBP12	STRCO|Gene=CAB59491|UniProtKB=Q9RJ63	Peptidyl-prolyl cis-trans isomerase	ISS			PTHR10516:SF341	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE
P02738	De novo purine biosynthesis	P02905	Amidophosphoribosyl transferase	BACSU|EnsemblGenome=BSU06490|UniProtKB=P00497	Amidophosphoribosyltransferase	ISS			PTHR11907:SF0	AMIDOPHOSPHORIBOSYLTRANSFERASE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00004	Alzheimer disease-presenilin pathway	P00170	Aph-1	DANRE|ZFIN=ZDB-GENE-031118-31|UniProtKB=Q8JHE9	Gamma-secretase subunit Aph-1b	ISS	12110170	PubMed	PTHR12889:SF1	GAMMA-SECRETASE SUBUNIT APH-1B
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00019	Endothelin signaling pathway	P00591	PLCbeta	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	ORYSJ|EnsemblGenome=OS07G0114400|UniProtKB=Q8H386	Casein kinase II alpha subunit	ISS	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CAEBR|Gene=CBG23091|UniProtKB=A8Y4Q9	Protein CBR-ACT-2	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00048	PI3 kinase pathway	P01185	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00640	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	ISS	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	PANTR|Ensembl=ENSPTRG00000000843|UniProtKB=H2QZN8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P02727	Androgen/estrogene/progesterone biosynthesis	P02826	Estradiol 17beta-dehydrogenase	HUMAN|HGNC=5215|UniProtKB=P56937	3-keto-steroid reductase	RCA			PTHR44442:SF1	3-KETO-STEROID REDUCTASE
P04393	Ras Pathway	P04541	p90RSK	HUMAN|HGNC=10431|UniProtKB=Q15349	Ribosomal protein S6 kinase alpha-2	IDA	15526037	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000012922|UniProtKB=H2QJF2	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05915	Opioid proenkephalin pathway	P05994	G-protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	ISS	10704417	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05918	p38 MAPK pathway	P06020	p38delta	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	RCA	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1346875|UniProtKB=O08648	Mitogen-activated protein kinase kinase kinase 4	IC			PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00023	General transcription regulation	P00658	TBP-associated factors	RAT|RGD=621487|UniProtKB=F1LNY6	Protein Taf2	ISS			PTHR15137:SF9	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00021	FGF signaling pathway	P00629	PP2A	ARATH|TAIR=AT5G03470|UniProtKB=O04375	Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' alpha isoform	ISS			PTHR10257:SF3	PP2A-B', ISOFORM B
P04393	Ras Pathway	P04546	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00036	Interleukin signaling pathway	P00981	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05918	p38 MAPK pathway	P05920	MAPKAP-K2	PANTR|Ensembl=ENSPTRG00000001915|UniProtKB=H2Q104	Mitogen-activated protein kinase-activated protein kinase 2	ISS	9628873	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00057	Wnt signaling pathway	P01443	Phospholipase C	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	CANAL|CGD=CAL0000176261|UniProtKB=P53704	Glutamine--fructose-6-phosphate aminotransferase [isomerizing]	ISS			PTHR10937:SF0	GH12731P-RELATED
P00056	VEGF signaling pathway	P01408	Akt/PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00371	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00054	Toll receptor signaling pathway	P01368	MKK2	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00030	Hypoxia response via HIF activation	P00819	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CANLF|Ensembl=ENSCAFG00000012623|UniProtKB=F1PVP1	Uncharacterized protein	ISS	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00021	FGF signaling pathway	P00640	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	IGI	96009592	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8671|UniProtKB=Q9Y5H7	Protocadherin alpha-5	IDA	8120095	PubMed	PTHR24028:SF111	PROTOCADHERIN ALPHA-5
P02743	Formyltetrahydroformate biosynthesis	P02956	Formyl tetrahydrofolate deformylase	SYNY3|EnsemblGenome=BAA10270|UniProtKB=Q55135	Formyltetrahydrofolate deformylase	ISS			PTHR42706:SF1	FORMYLTETRAHYDROFOLATE DEFORMYLASE 1, MITOCHONDRIAL-RELATED
P00056	VEGF signaling pathway	P01414	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g240980|UniProtKB=A7RVJ0	Serine/threonine-protein phosphatase	ISS	8392016	PubMed	PTHR11668:SF402	SERINE/THREONINE-PROTEIN PHOSPHATASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04494	TSC2	MOUSE|MGI=MGI=102548|UniProtKB=Q61037	Tuberin	IDA	12150915	PubMed	PTHR10063:SF0	TUBERIN
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00012	Cadherin signaling pathway	P00477	GSK3beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MOUSE|MGI=MGI=101848|UniProtKB=P62881	Guanine nucleotide-binding protein subunit beta-5	ISS	11313908	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IDA	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	RAT|RGD=2520|UniProtKB=P61169	D(2) dopamine receptor	ISS	11861492	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00047	PDGF signaling pathway	P01153	GSK3	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00007	Axon guidance mediated by semaphorins	P00336	Cdk5	MOUSE|MGI=MGI=101765|UniProtKB=P49615	Cyclin-dependent-like kinase 5	ISS			PTHR24056:SF46	CYCLIN-DEPENDENT-LIKE KINASE 5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CANLF|Ensembl=ENSCAFG00000015915|UniProtKB=E2QUF7	Uncharacterized protein	ISS			PTHR18945:SF489	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-9
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IC	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00058	mRNA splicing	P01476	U4	YEAST|SGD=S000002881|UniProtKB=Q03338	U4/U6 small nuclear ribonucleoprotein PRP3	ISS	9169867	PubMed	PTHR14212:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3
P00053	T cell activation	P01300	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00050	Plasminogen activating cascade	P01255	Plasminogen	PANTR|Ensembl=ENSPTRG00000018774|UniProtKB=H2QU06	Plasminogen	ISS	4505881	gi	PTHR24261:SF6	PLASMINOGEN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00828	Galphai	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	RCA			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04393	Ras Pathway	P04570	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IDA	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01162	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	MONDO|Ensembl=ENSMODG00000015693|UniProtKB=F7E0R2	Uncharacterized protein	ISS			PTHR11405:SF5	CAD PROTEIN
P00054	Toll receptor signaling pathway	P01356	ERK2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	MOUSE|MGI=MGI=102891|UniProtKB=P51829	Adenylate cyclase type 7	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00001	Adrenaline and noradrenaline biosynthesis	P00070	VAT2	RAT|RGD=3694|UniProtKB=Q01827	Synaptic vesicular amine transporter	ISS	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00021	FGF signaling pathway	P00624	14-3-3	PLAF7|EnsemblGenome=MAL8P1.69|UniProtKB=C0H4V6	14-3-3 protein	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000012922|UniProtKB=H2QJF2	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P04393	Ras Pathway	P04559	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00627	ERK1-2	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00564	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	ANOGA|EnsemblGenome=AGAP008908|UniProtKB=Q7PWN2	AGAP008908-PA	ISS	12932731	PubMed	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00006	Apoptosis signaling pathway	P00316	Bcl-w	RAT|RGD=620717|UniProtKB=O88996	BCL-W	ISS	8761287	PubMed	PTHR11256:SF13	BCL-2-LIKE PROTEIN 2
P00029	Huntington disease	P00778	NMDA receptor	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	IDA	14698601	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00018	EGF receptor signaling pathway	P00554	Shc	HUMAN|HGNC=18181|UniProtKB=Q92529	SHC-transforming protein 3	IGI	96404502	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P00056	VEGF signaling pathway	P01423	p38MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04393	Ras Pathway	P04544	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	11384839	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01135	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MONDO|Ensembl=ENSMODG00000020977|UniProtKB=F6S5B1	Uncharacterized protein (Fragment)	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	9199552	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00019	Endothelin signaling pathway	P00590	IP3 R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IGI	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	XENTR|Ensembl=ENSXETG00000021375|UniProtKB=F6T423	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00012	Cadherin signaling pathway	P00471	Cadherin	XENTR|Xenbase=XB-GENE-983603|UniProtKB=F6ZXH1	Uncharacterized protein	ISS	8120095	PubMed	PTHR43912:SF3	PROTOCADHERIN-1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	91072385	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00059	p53 pathway	P01480	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	IGI	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01432	Beta-Catenin	CANLF|Ensembl=ENSCAFG00000005204|UniProtKB=B6V8E6	Catenin beta-1	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00021	FGF signaling pathway	P00627	ERK1-2	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00047	PDGF signaling pathway	P01143	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00976	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00047	PDGF signaling pathway	P01142	p90RSK	HUMAN|HGNC=10433|UniProtKB=O75676	Ribosomal protein S6 kinase alpha-4	ISS	6755374	gi	PTHR24351:SF41	RIBOSOMAL PROTEIN S6 KINASE ALPHA-4
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IDA	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00004	Alzheimer disease-presenilin pathway	P00127	APP	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00057	Wnt signaling pathway	P01435	SWI/SNF	MOUSE|MGI=MGI=1328366|UniProtKB=Q9Z0H3	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1	IDA	11532957	PubMed	PTHR10019:SF5	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY B MEMBER 1
P00019	Endothelin signaling pathway	P00576	Pre-pro ET1-4	RAT|RGD=2532|UniProtKB=P22388	Endothelin-1	ISS	12773307	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	RAT|RGD=2739|UniProtKB=Q00961	Glutamate receptor ionotropic, NMDA 2C	IC	11319238	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00059	p53 pathway	P04609	PI3K	CANAL|CGD=CAL0068551|UniProtKB=Q5AAR9	Phosphatidylinositol 3-kinase	ISS	20330542	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00056	VEGF signaling pathway	P01423	p38MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00638	PLCgamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00029	Huntington disease	P00779	TBP	ENTHI|Gene=EHI_112050|UniProtKB=C4M7H7	TATA-box-binding protein 2	IPI	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	CAEBR|Gene=CBG19843|UniProtKB=A8XWK5	S-adenosylmethionine synthase	ISS			PTHR11964:SF1	S-ADENOSYLMETHIONINE SYNTHASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	TAS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00054	Toll receptor signaling pathway	P01358	ERK1	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00384	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IDA	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01444	Wnt	PANTR|Ensembl=ENSPTRG00000002062|UniProtKB=H2Q194	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00010	B cell activation	P00383	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02721	ATP synthesis	P02791	F1 alpha	BOVIN|Gene=ATP5A1|UniProtKB=P19483	ATP synthase subunit alpha, mitochondrial	ISS	2527557	PubMed	PTHR43089:SF4	ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04393	Ras Pathway	P04572	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	IDA	11707292	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P06959	CCKR signaling map	P07090	MAPK8-10	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	RCA	15153424	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01443	Phospholipase C	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00029	Huntington disease	P00810	GAPDH	CHLRE|EnsemblGenome=CHLREDRAFT_140618|UniProtKB=A8JHR9	Glyceraldehyde-3-phosphate dehydrogenase	IPI			PTHR10836:SF76	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE A
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	DICDI|dictyBase=DDB_G0293434|UniProtKB=P15064	Ras-like protein rasG	ISS	89128893	PubMed	PTHR24070:SF282	RAS GTPASE-RELATED
P00045	Notch signaling pathway	G01541	E(spl)-C genes	DROME|FlyBase=FBgn0002633|UniProtKB=P13097	Enhancer of split m7 protein	TAS	14973298	PubMed	PTHR10985:SF12	ENHANCER OF SPLIT M3 PROTEIN-RELATED
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00558	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05913	Enkephalin release	G06046	preproenkephalin mRNA	PANTR|Ensembl=ENSPTRG00000020270|UniProtKB=H2QW70	Proenkephalin	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00021	FGF signaling pathway	P00629	PP2A	MACMU|Ensembl=ENSMMUG00000008205|UniProtKB=F7GWP9	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	ISS	8703017	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00054	Toll receptor signaling pathway	P01380	TLR1,2,6	BOVIN|Gene=TLR2|UniProtKB=Q95LA9	Toll-like receptor 2	ISS			PTHR24365:SF17	TOLL-LIKE RECEPTOR 2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05730	Endogenous cannabinoid signaling	P05743	CB1	PANTR|Ensembl=ENSPTRG00000018411|UniProtKB=Q5IS73	Cannabinoid receptor 1	ISS	114610	OMIM	PTHR22750:SF47	CANNABINOID RECEPTOR 1
P00012	Cadherin signaling pathway	P00470	F-actin	PHYPA|Gene=PHYPADRAFT_198730|UniProtKB=Q6TYS2	Actin 1	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CIOIN|Ensembl=ENSCING00000000848|UniProtKB=F6SCP4	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01192	p110	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00565	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	MOUSE|MGI=MGI=1933185|UniProtKB=P70303	CTP synthase 2	ISS			PTHR11550:SF2	CTP SYNTHASE 2
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ARATH|TAIR=AT5G19010|UniProtKB=Q8W4J2	Mitogen-activated protein kinase 16	IDA			PTHR24055:SF211	MITOGEN-ACTIVATED PROTEIN KINASE 16
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	ISS			PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	HUMAN|HGNC=4401|UniProtKB=O14775	Guanine nucleotide-binding protein subunit beta-5	RCA	11313908	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CAEEL|WormBase=WBGene00000048|UniProtKB=Q18556	AcetylCholine Receptor	IC	85270494	PubMed	PTHR18945:SF528	ACETYLCHOLINE RECEPTOR
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000002775|UniProtKB=H2RB55	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00015	Circadian clock system	G01499	per	CANLF|Ensembl=ENSCAFG00000016984|UniProtKB=E2R0I6	Uncharacterized protein	ISS	12782655	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P00021	FGF signaling pathway	P00648	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IGI	10395542	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00045	Notch signaling pathway	P01109	Aph-1	PANTR|Ensembl=ENSPTRG00000007146|UniProtKB=H2Q9J9	Anterior pharynx defective 1 homolog B	ISS	12110170	PubMed	PTHR12889:SF1	GAMMA-SECRETASE SUBUNIT APH-1B
P00018	EGF receptor signaling pathway	P00547	PP2A	MACMU|Ensembl=ENSMMUG00000013047|UniProtKB=F7H808	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	RAT|RGD=621060|UniProtKB=O88777	Presenilin-2	TAS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	TAS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	RAT|RGD=3696|UniProtKB=P51907	Excitatory amino acid transporter 3	ISS	96032356	PubMed	PTHR11958:SF69	EXCITATORY AMINO ACID TRANSPORTER 3
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Gene=CHRM2|UniProtKB=Q9N2A7	Muscarinic acetylcholine receptor M2 (Fragment)	ISS	10069496	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00023	General transcription regulation	P00658	TBP-associated factors	CANLF|Ensembl=ENSCAFG00000007766|UniProtKB=E2R911	Uncharacterized protein	ISS			PTHR12595:SF8	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 9
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	MONDO|Ensembl=ENSMODG00000011791|UniProtKB=F7CBU9	Phospholipase A2	ISS	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00059	p53 pathway	P04609	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	ISS	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P02772	Pyruvate metabolism	P03132	Pyruvate Kinase	RAT|RGD=3337|UniProtKB=P11980	Pyruvate kinase PKM	TAS	8193145	PubMed	PTHR11817:SF23	SUBFAMILY NOT NAMED
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	PANTR|Ensembl=ENSPTRG00000006872|UniProtKB=H2RCB4	Uncharacterized protein	ISS	15226293	PubMed	PTHR13715:SF16	RYANODINE RECEPTOR 3
P00048	PI3 kinase pathway	P01177	P110ACT	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	CHICK|Ensembl=ENSGALG00000011558|UniProtKB=F1NWV6	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	ARATH|TAIR=AT4G13930|UniProtKB=O23254	Serine hydroxymethyltransferase 4	ISS			PTHR11680:SF28	SERINE HYDROXYMETHYLTRANSFERASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00008	Axon guidance mediated by Slit/Robo	P00342	Slit	MACMU|Ensembl=ENSMMUG00000002614|UniProtKB=F7H9D3	Uncharacterized protein	ISS	10432110	PubMed	PTHR24373:SF107	SLIT HOMOLOG 2 PROTEIN
P00045	Notch signaling pathway	P01110	Presenilin	BOVIN|Ensembl=ENSBTAG00000011757|UniProtKB=Q9XT97	Presenilin-1	ISS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P02775	Salvage pyrimidine ribonucleotides	P03151	Uracil phosphoribosyl  transferase	BACSU|EnsemblGenome=BSU36890|UniProtKB=P39149	Uracil phosphoribosyltransferase	ISS			PTHR10285:SF46	URACIL PHOSPHORIBOSYLTRANSFERASE, CHLOROPLASTIC
P00049	Parkinson disease	P01231	gamma-Synuclein	PANTR|Ensembl=ENSPTRG00000002708|UniProtKB=H2Q274	Gamma-synuclein	ISS			PTHR13820:SF10	GAMMA-SYNUCLEIN
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	RAT|RGD=69430|UniProtKB=P32851	Syntaxin-1A	IC	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P02751	Lysine biosynthesis	P03006	Dihydrodipicolinate  reductase	LEPIN|EnsemblGenome=LA_3305|UniProtKB=Q8F133	4-hydroxy-tetrahydrodipicolinate reductase	ISS			PTHR20836:SF0	DIHYDRODIPICOLINATE REDUCTASE-LIKE PROTEIN CRR1, CHLOROPLASTIC
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IGI	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00053	T cell activation	P01307	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00054	Toll receptor signaling pathway	P01369	MKK1	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IDA	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	MOUSE|MGI=MGI=96770|UniProtKB=P27782	Lymphoid enhancer-binding factor 1	TAS	11266476	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01215	Syntaxin	PANTR|Ensembl=ENSPTRG00000018607|UniProtKB=H2QTR3	Syntaxin 7	ISS	14570579	PubMed	PTHR19957:SF90	SYNTAXIN-7
P00034	Integrin signalling pathway	P00907	ERK	CANLF|Ensembl=ENSCAFG00000000760|UniProtKB=E2R9L4	Uncharacterized protein	ISS			PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P02755	Methylmalonyl pathway	P03034	Methylmalonyl-CoA mutase	STRCO|Gene=CAB70645|UniProtKB=Q7AKG5	Isobutyryl-CoA mutase A	ISS			PTHR43589:SF3	SUBFAMILY NOT NAMED
P00025	Hedgehog signaling pathway	P00697	Sap18	XENTR|Xenbase=XB-GENE-481689|UniProtKB=Q28FL5	Sin3-associated polypeptide, 18kDa	ISS	11960000	PubMed	PTHR13082:SF0	HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18
P00006	Apoptosis signaling pathway	P00297	NFkappaB	HUMAN|HGNC=7794|UniProtKB=P19838	Nuclear factor NF-kappa-B p105 subunit	ISS	12574369	PubMed	PTHR24169:SF9	NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT
P00010	B cell activation	P00398	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00010	B cell activation	P00391	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00048	PI3 kinase pathway	P01192	p110	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01142	p90RSK	MACMU|Ensembl=ENSMMUG00000007610|UniProtKB=F6SDH6	Ribosomal protein S6 kinase	ISS	9792677	PubMed	PTHR24351:SF41	RIBOSOMAL PROTEIN S6 KINASE ALPHA-4
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	91056091	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00010	B cell activation	P00401	jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00047	PDGF signaling pathway	P01149	MNK1/2	RAT|RGD=1305728|UniProtKB=Q5U2N4	MAP kinase-interacting serine/threonine-protein kinase 2	ISS	9155017	PubMed	PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	IDA	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000015240|UniProtKB=F6VUY3	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P04397	p53 pathway by glucose deprivation	P04640	p53	HUMAN|HGNC=11998|UniProtKB=P04637	Cellular tumor antigen p53	TAS	11313951	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00029	Huntington disease	P00790	beta-Tubulin	CHICK|Ensembl=ENSGALG00000012821|UniProtKB=P32882	Tubulin beta-2 chain	TAS	12932731	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P05913	Enkephalin release	P05974	G-Protein (i)	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01188	Gbetagamma	CAEEL|WormBase=WBGene00001680|UniProtKB=Q20636	Guanine nucleotide-binding protein subunit beta-2	IGI	11250160	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	NEUCR|EnsemblGenome=EFNCRG00000003893|UniProtKB=P78711	Actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00021	FGF signaling pathway	P00632	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01443	Phospholipase C	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00048	PI3 kinase pathway	P01177	P110ACT	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IDA	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00036	Interleukin signaling pathway	P00965	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	IC	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=16267|UniProtKB=Q9UBV4	Protein Wnt-16	TAS	8717036	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P00019	Endothelin signaling pathway	P00566	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	CHICK|Ensembl=ENSGALG00000015434|UniProtKB=F1NU20	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00005	Angiogenesis	P00233	CSL	TAKRU|Ensembl=ENSTRUG00000014798|UniProtKB=H2ULI5	Uncharacterized protein	ISS	12145413	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00375	Calmodulin	MONDO|Ensembl=ENSMODG00000025146|UniProtKB=F7CLC0	Uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF311	CALMODULIN
P05913	Enkephalin release	P05974	G-Protein (i)	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	IC	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00024	Glycolysis	P00675	Pyruvate kinase	HUMAN|HGNC=9020|UniProtKB=P30613	Pyruvate kinase PKLR	RCA			PTHR11817:SF31	PYRUVATE KINASE PKLR
P00057	Wnt signaling pathway	P01437	TCF	BOVIN|Ensembl=ENSBTAG00000010111|UniProtKB=F1MJS2	Uncharacterized protein	ISS	11266476	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P05916	Opioid prodynorphin pathway	P06002	G-protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000002775|UniProtKB=H2RB55	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00048	PI3 kinase pathway	P01199	Galpha	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Ensembl=ENSPTRG00000022245|UniProtKB=H2QZ29	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00009	Axon guidance mediated by netrin	P00363	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00005	Angiogenesis	P00226	Delta/Serrate	PANTR|Ensembl=ENSPTRG00000006937|UniProtKB=H2R342	Delta-like protein	ISS	11798067	PubMed	PTHR24044:SF320	DELTA-LIKE PROTEIN 4
P00057	Wnt signaling pathway	P01465	Ggamma	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00471	Cadherin	ANOGA|EnsemblGenome=AGAP006732|UniProtKB=Q7PT75	AGAP006732-PA	ISS	8120095	PubMed	PTHR24026:SF71	FAT-LIKE CADHERIN-RELATED TUMOR SUPPRESSOR HOMOLOG
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	8649368	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	RAT|RGD=61863|UniProtKB=P19493	Glutamate receptor 4	ISS	12497607	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ORNAN|Ensembl=ENSOANG00000007716|UniProtKB=F6UDX9	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	MONDO|Ensembl=ENSMODG00000000771|UniProtKB=F6SSS3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=99218|UniProtKB=P39038	Cadherin-4	IDA	8120095	PubMed	PTHR24027:SF81	CADHERIN-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IDA	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00047	PDGF signaling pathway	P01150	PKC	HUMAN|HGNC=9406|UniProtKB=Q16513	Serine/threonine-protein kinase N2	ISS	125549	gi	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IGI	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00059	p53 pathway	P01486	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00022	General transcription by RNA polymerase I	P00657	TBP	ARATH|TAIR=AT1G55520|UniProtKB=P28148	TATA-box-binding protein 2	ISS	11988536	PubMed	PTHR10126:SF36	TATA-BOX-BINDING PROTEIN 1-RELATED
P00021	FGF signaling pathway	P00624	14-3-3	EMENI|EnsemblGenome=CADANIAG00005943|UniProtKB=Q5B4M9	1433_TRIHA 14-3-3 PROTEIN HOMOLOG (TH1433)	IGI	12023078	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	RAT|RGD=2026|UniProtKB=P68035	Actin, alpha cardiac muscle 1	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	MOUSE|MGI=MGI=2651588|UniProtKB=Q8VHQ2	Suppressor of cytokine signaling 7	TAS	15032587	PubMed	PTHR45052:SF1	SUPPRESSOR OF CYTOKINE SIGNALING 7
P02743	Formyltetrahydroformate biosynthesis	P02952	Methylene tetrahydrofolate dehydrogenase	BACSU|EnsemblGenome=BSU24310|UniProtKB=P54382	Bifunctional protein FolD	ISS			PTHR10025:SF46	BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, MITOCHONDRIAL
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	ARATH|TAIR=AT1G54360|UniProtKB=F4HVA6	Transcription initiation factor TFIID subunit 6b	ISS			PTHR10221:SF9	TAF6-LIKE RNA POLYMERASE II P300/CBP-ASSOCIATED FACTOR-ASSOCIATED FACTOR 65 KDA SUBUNIT 6L
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P02756	N-acetylglucosamine metabolism	P03043	N-acetylglucosamine-1-phosphate uridyltransferase	AQUAE|EnsemblGenome=aq_607|UniProtKB=O66863	Bifunctional protein GlmU	ISS			PTHR43584:SF3	BIFUNCTIONAL PROTEIN GLMU
P00054	Toll receptor signaling pathway	P01369	MKK1	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02776	Serine glycine biosynthesis	P03159	Phosphoserine phosphatase	DROME|FlyBase=FBgn0023129|UniProtKB=Q9VSY6	Phosphoserine phosphatase	ISS			PTHR43344:SF2	PHOSPHOSERINE PHOSPHATASE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04393	Ras Pathway	P04567	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MONDO|Ensembl=ENSMODG00000004799|UniProtKB=F6VM87	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04567	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	XENTR|GeneID=394982|UniProtKB=P20399	Actin, alpha cardiac muscle 2	ISS	14684598	PubMed	PTHR11937:SF263	ACTIN
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	HUMAN|HGNC=11513|UniProtKB=O00445	Synaptotagmin-5	RCA			PTHR10024:SF282	SYNAPTOTAGMIN-5
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00034	Integrin signalling pathway	P00922	Collagen	MOUSE|MGI=MGI=88457|UniProtKB=O88207	Collagen alpha-1(V) chain	IDA	10778855	PubMed	PTHR24023:SF387	COLLAGEN ALPHA-1 V  CHAIN
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P05918	p38 MAPK pathway	P06043	ASK1	HUMAN|HGNC=6857|UniProtKB=Q99683	Mitogen-activated protein kinase kinase kinase 5	TAS	12697749	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00006	Apoptosis signaling pathway	P00321	HSP70	DROME|FlyBase=FBgn0001230|UniProtKB=O97125	Heat shock protein 68	ISS	12150907	PubMed	PTHR19375:SF256	HSP70 PROTEIN-RELATED
P00048	PI3 kinase pathway	P01200	SHIP	BOVIN|Ensembl=ENSBTAG00000019167|UniProtKB=E1BBJ7	Uncharacterized protein	ISS	10381377	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P05916	Opioid prodynorphin pathway	P06002	G-protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	HUMAN|HGNC=172|UniProtKB=P36896	Activin receptor type-1B	TAS	10683140	PubMed	PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P02738	De novo purine biosynthesis	P02909	GDP reductase	BOVIN|Ensembl=ENSBTAG00000021208|UniProtKB=E1BFQ8	Uncharacterized protein	ISS			PTHR23409:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 B
P00036	Interleukin signaling pathway	P00990	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IC	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00702	CPB	HUMAN|HGNC=18855|UniProtKB=Q68CJ9	Cyclic AMP-responsive element-binding protein 3-like protein 3	ISS			PTHR22952:SF98	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 3
P00053	T cell activation	P01319	PAK	PANTR|Ensembl=ENSPTRG00000022187|UniProtKB=Q7YQL4	Serine/threonine-protein kinase PAK 3	ISS	11259591	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P04393	Ras Pathway	P04557	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	IDA	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00807	Actin	HUMAN|HGNC=17780|UniProtKB=Q562R1	Beta-actin-like protein 2	IDA	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00034	Integrin signalling pathway	P00944	Actin	TAKRU|Ensembl=ENSTRUG00000005447|UniProtKB=P68142	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF354	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01275	P38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	TAS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01143	ERK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6879|UniProtKB=Q16659	Mitogen-activated protein kinase 6	IDA	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00548	RKIP	MOUSE|MGI=MGI=1344408|UniProtKB=P70296	Phosphatidylethanolamine-binding protein 1	IGI	11034991	PubMed	PTHR11362:SF10	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00010	B cell activation	P00385	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	CHICK|Ensembl=ENSGALG00000015358|UniProtKB=F1NM49	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF575	MYOSIN-15
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00021	FGF signaling pathway	P00633	Ras	DICPU|Gene=DICPUDRAFT_91367|UniProtKB=F0ZB76	Putative uncharacterized protein rasD	ISS	6091907	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00181	SHP2	MONDO|Ensembl=ENSMODG00000003120|UniProtKB=F6WVD2	Tyrosine-protein phosphatase non-receptor type	ISS	14525967	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00015	Circadian clock system	P00502	Casein kinase I	MACMU|Ensembl=ENSMMUG00000010122|UniProtKB=F7HF84	Casein kinase I isoform epsilon	ISS	11865049	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	ARATH|TAIR=AT2G29900|UniProtKB=Q9SIK7	Presenilin-like protein At2g29900	TAS	12834808	PubMed	PTHR10202:SF22	SUBFAMILY NOT NAMED
P00008	Axon guidance mediated by Slit/Robo	P00355	Rho	ORNAN|Ensembl=ENSOANG00000008835|UniProtKB=F7FR08	Uncharacterized protein	ISS	13679859	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00010	B cell activation	P00373	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IGI	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04393	Ras Pathway	P04547	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00018	EGF receptor signaling pathway	P00562	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05913	Enkephalin release	P05972	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01286	TGFbeta	DROME|FlyBase=FBgn0024234|UniProtKB=P27091	Protein 60A	TAS	9759503	PubMed	PTHR11848:SF54	PROTEIN 60A-RELATED
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=1952|UniProtKB=P20309	Muscarinic acetylcholine receptor M3	IDA			PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00059	p53 pathway	P01486	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	TAS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00586	Gq	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00047	PDGF signaling pathway	P01174	Rho	BOVIN|Ensembl=ENSBTAG00000032289|UniProtKB=A4IF90	Rho GTPase-activating protein 15	ISS	8288572	PubMed	PTHR23181:SF5	RHO GTPASE-ACTIVATING PROTEIN 15
P00046	Oxidative stress response	P01135	p38	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	TAS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00002	Alpha adrenergic receptor signaling pathway	P00078	Alpha1A/1B/1C	PANTR|Ensembl=ENSPTRG00000017482|UniProtKB=H2QRX4	Uncharacterized protein	ISS	6323229	PubMed	PTHR24248:SF17	ALPHA-1B ADRENERGIC RECEPTOR
P06959	CCKR signaling map	P07145	Paxillin	HUMAN|HGNC=9718|UniProtKB=P49023	Paxillin	RCA	14667936	PubMed	PTHR24216:SF11	PAXILLIN
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-040426-2427|UniProtKB=F1Q6C0	Uncharacterized protein (Fragment)	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01284	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	HALSA|EnsemblGenome=VNG_1814G|UniProtKB=Q9HP43	Carbamoyl-phosphate synthase large chain	ISS			PTHR11405:SF5	CAD PROTEIN
P00021	FGF signaling pathway	P00627	ERK1-2	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	TAS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	PANTR|Ensembl=ENSPTRG00000011718|UniProtKB=H2QHJ5	Adenylate cyclase 3	ISS	2491850	PubMed	PTHR11920:SF291	ADENYLATE CYCLASE TYPE 3
P00056	VEGF signaling pathway	P01417	Raf	MOUSE|MGI=MGI=88190|UniProtKB=P28028	Serine/threonine-protein kinase B-raf	ISS	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9406|UniProtKB=Q16513	Serine/threonine-protein kinase N2	TAS	10644715	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	HUMAN|HGNC=9857|UniProtKB=P61224	Ras-related protein Rap-1b	IDA	1904317	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00029	Huntington disease	P00786	ARF	HUMAN|HGNC=656|UniProtKB=P49703	ADP-ribosylation factor-like protein 4D	IPI	12932731	PubMed	PTHR11711:SF137	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 4D
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04393	Ras Pathway	P04572	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	IDA	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P06664	Gonadotropin-releasing hormone receptor pathway	P06812	L-type Ca2+	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	RCA	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00029	Huntington disease	G01535	PIG3	PANTR|Ensembl=ENSPTRG00000009234|UniProtKB=H2R0X1	Uncharacterized protein	ISS	12932731	PubMed	PTHR44054:SF1	SYNAPTIC VESICLE MEMBRANE PROTEIN VAT-1 HOMOLOG
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01452	NFAT	HUMAN|HGNC=7775|UniProtKB=O95644	Nuclear factor of activated T-cells, cytoplasmic 1	IDA	12015605	PubMed	PTHR12533:SF5	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00049	Parkinson disease	P01236	Casein kinase II	YEAST|SGD=S000005565|UniProtKB=P38930	Casein kinase II subunit beta'	IDA	10617630	PubMed	PTHR11740:SF13	CASEIN KINASE II SUBUNIT BETA'
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	10395542	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00025	Hedgehog signaling pathway	P00682	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	RAT|RGD=3694|UniProtKB=Q01827	Synaptic vesicular amine transporter	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00021	FGF signaling pathway	P00632	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P05918	p38 MAPK pathway	P06015	p38gamma	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	8925912	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00034	Integrin signalling pathway	P00925	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IDA	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PANTR|Ensembl=ENSPTRG00000013428|UniProtKB=H2QK88	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF358	MYOSIN-7B
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	HUMAN|HGNC=11641|UniProtKB=Q9NQB0	Transcription factor 7-like 2	TAS	9118222	PubMed	PTHR10373:SF32	TRANSCRIPTION FACTOR 7-LIKE 2
P00006	Apoptosis signaling pathway	P00269	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00005	Angiogenesis	P00238	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	MOUSE|MGI=MGI=96435|UniProtKB=Q07113	Cation-independent mannose-6-phosphate receptor	ISS	11081635	PubMed	PTHR15071:SF17	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=2685045|UniProtKB=E9QAN8	Protein Pik3c2b	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05917	Opioid proopiomelanocortin pathway	P06010	proopiomelanocortin	RAT|RGD=3366|UniProtKB=P01194	Pro-opiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00029	Huntington disease	P00807	Actin	PHYPA|Gene=PHYPADRAFT_225906|UniProtKB=A9TVP1	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00060	Ubiquitin proteasome pathway	P01490	E3	BOVIN|Ensembl=ENSBTAG00000010422|UniProtKB=F1MYE6	Uncharacterized protein	ISS	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00008	Axon guidance mediated by Slit/Robo	P00344	Netrin	MOUSE|MGI=MGI=105088|UniProtKB=O09118	Netrin-1	ISS	11356879	PubMed	PTHR10574:SF365	NETRIN-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P06959	CCKR signaling map	P07111	TRAF6	HUMAN|HGNC=12036|UniProtKB=Q9Y4K3	TNF receptor-associated factor 6	RCA	12740336	PubMed	PTHR10131:SF111	TNF RECEPTOR-ASSOCIATED FACTOR 6
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00021	FGF signaling pathway	P00628	JNK1-3	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00029	Huntington disease	G01535	PIG3	HUMAN|HGNC=2419|UniProtKB=Q08257	Quinone oxidoreductase	TAS	12932731	PubMed	PTHR44154:SF1	QUINONE OXIDOREDUCTASE
P00049	Parkinson disease	P01238	14-3-3	HUMAN|HGNC=12851|UniProtKB=P62258	14-3-3 protein epsilon	ISS	9450960	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02743	Formyltetrahydroformate biosynthesis	P02952	Methylene tetrahydrofolate dehydrogenase	XENTR|Xenbase=XB-GENE-941965|UniProtKB=B3DL74	LOC100170462 protein	ISS			PTHR10025:SF39	BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00054	Toll receptor signaling pathway	P01375	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00014	Cholesterol biosynthesis	P00499	Farnesyl-diphosphate farnesyltransferase	PANTR|Ensembl=ENSPTRG00000019997|UniProtKB=H2QVR6	Farnesyl-diphosphate farnesyltransferase 1	ISS			PTHR11626:SF2	SQUALENE SYNTHASE
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	IDA	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=5302|UniProtKB=P34969	5-hydroxytryptamine receptor 7	IDA			PTHR24247:SF116	5-HYDROXYTRYPTAMINE RECEPTOR 7
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000005147|UniProtKB=O77680	D(1A) dopamine receptor	IDA			PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	IDA	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CAEBR|Gene=CBG05858|UniProtKB=A8X1H0	Protein CBR-EGL-19 (Fragment)	ISS	8838325	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00049	Parkinson disease	P01222	Ubc6	RAT|RGD=1359523|UniProtKB=A0A0G2K8C5	Protein Ube2j2	ISS	12859888	PubMed	PTHR43972:SF1	UBIQUITIN-CONJUGATING ENZYME E2 J2
P04393	Ras Pathway	P04558	p38	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	8925912	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000004474|UniProtKB=E2RCN6	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	CANLF|Ensembl=ENSCAFG00000011236|UniProtKB=E2R9F8	Uncharacterized protein	ISS	12356903	PubMed	PTHR10845:SF103	AXIN-2
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-030131-7595|UniProtKB=Q6PBR4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00047	PDGF signaling pathway	P01151	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00010	B cell activation	P00381	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00046	Oxidative stress response	P01135	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MACMU|Ensembl=ENSMMUG00000011949|UniProtKB=F7HIJ6	Alpha-centractin	ISS	14684598	PubMed	PTHR11937:SF46	ALPHA-CENTRACTIN
P00012	Cadherin signaling pathway	P00470	F-actin	ORYSJ|EnsemblGenome=OS12G0163700|UniProtKB=Q0IPW3	Os12g0163700 protein	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MACMU|Ensembl=ENSMMUG00000009054|UniProtKB=F7F735	Uncharacterized protein	ISS	20112749	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CHICK|Ensembl=ENSGALG00000014539|UniProtKB=F1N861	Uncharacterized protein	ISS	1321498	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DROME|FlyBase=FBgn0001122|UniProtKB=P16378	G protein alpha o subunit	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	HUMAN|HGNC=237|UniProtKB=O43306	Adenylate cyclase type 6	IGI	10978539	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P04398	p53 pathway feedback loops 2	P04654	Rb	RAT|RGD=3540|UniProtKB=P33568	Retinoblastoma-associated protein	ISS			PTHR13742:SF17	RETINOBLASTOMA-ASSOCIATED PROTEIN
P00054	Toll receptor signaling pathway	P01380	TLR1,2,6	CHICK|Gene=TLR2-2|UniProtKB=Q9DGB6	Toll-like receptor 2 type-2	ISS			PTHR24365:SF17	TOLL-LIKE RECEPTOR 2
P04398	p53 pathway feedback loops 2	P04665	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P02738	De novo purine biosynthesis	P02902	ADP reductase	ECOLI|EcoGene=EG10660|UniProtKB=P00452	Ribonucleoside-diphosphate reductase 1 subunit alpha	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CAEEL|WormBase=WBGene00006454|UniProtKB=G5EEN8	AEX-4	IC			PTHR19305:SF10	AEX-4
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01465	Ggamma	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00024	Glycolysis	P00680	Phosphoglyceromutase	CHLTR|EnsemblGenome=CT_722|UniProtKB=O84727	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase	ISS	20150255	PubMed	PTHR11931:SF0	AT20876P-RELATED
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00047	PDGF signaling pathway	P01152	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	2574500	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00470	F-actin	CHICK|Ensembl=ENSGALG00000011086|UniProtKB=P68139	Actin, alpha skeletal muscle	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IC	3755548	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00925	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IDA	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	PANTR|Ensembl=ENSPTRG00000006865|UniProtKB=H2Q930	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	IC	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00048	PI3 kinase pathway	P01202	p85	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00025	Hedgehog signaling pathway	P00682	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01178	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8051109	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00006	Apoptosis signaling pathway	P00310	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02756	N-acetylglucosamine metabolism	P03043	N-acetylglucosamine-1-phosphate uridyltransferase	DEIRA|EnsemblGenome=DR_0808|UniProtKB=Q9RW61	Bifunctional protein GlmU	ISS			PTHR43584:SF3	BIFUNCTIONAL PROTEIN GLMU
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00045	Notch signaling pathway	P01112	CoR	RAT|RGD=1309199|UniProtKB=Q5U2T8	Corepressor interacting with RBPJ 1	ISS	11112321	PubMed	PTHR13151:SF2	COREPRESSOR INTERACTING WITH RBPJ 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00046	Oxidative stress response	P01129	JNK1/2	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IDA	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00010	B cell activation	P00370	NFkappaB	HUMAN|HGNC=7795|UniProtKB=Q00653	Nuclear factor NF-kappa-B p100 subunit	IDA	20151924	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	TAS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00048	PI3 kinase pathway	P01177	P110ACT	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00326	FAS ligand	RAT|RGD=3880|UniProtKB=P36940	Tumor necrosis factor ligand superfamily member 6	ISS	12787569	PubMed	PTHR11471:SF33	TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 6
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IGI	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00030	Hypoxia response via HIF activation	P00817	TOR	MONDO|Ensembl=ENSMODG00000011138|UniProtKB=F7BA89	Uncharacterized protein	ISS	8662507	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00029	Huntington disease	P00811	Arp2/3 complex	HUMAN|HGNC=704|UniProtKB=O15143	Actin-related protein 2/3 complex subunit 1B	TAS	12473693	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	IC	11956331	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DICDI|dictyBase=DDB_G0277143|UniProtKB=P36408	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MACMU|Ensembl=ENSMMUG00000021725|UniProtKB=F7E738	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	ARATH|TAIR=AT1G55970|UniProtKB=Q9LG11	Histone acetyltransferase HAC4	IDA			PTHR13808:SF1	NEJIRE, ISOFORM C
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04393	Ras Pathway	P04552	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00018	EGF receptor signaling pathway	P00562	p38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	RAT|RGD=2739|UniProtKB=Q00961	Glutamate receptor ionotropic, NMDA 2C	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=1351345|UniProtKB=P47743	Metabotropic glutamate receptor 8	IDA	12351712	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00021	FGF signaling pathway	P00632	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	DICDI|dictyBase=DDB_G0277825|UniProtKB=O96622	Actin-related protein 2/3 complex subunit 1	ISS	12963527	gi	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05730	Endogenous cannabinoid signaling	P05743	CB1	CANLF|Ensembl=ENSCAFG00000003085|UniProtKB=F1Q345	Uncharacterized protein	ISS	2165569	PubMed	PTHR22750:SF47	CANNABINOID RECEPTOR 1
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	HUMAN|HGNC=4582|UniProtKB=Q16099	Glutamate receptor ionotropic, kainate 4	ISS	12941441	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	YEAST|SGD=S000000028|UniProtKB=P31109	Synaptobrevin homolog 1	ISS	93386758	PubMed	PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00021	FGF signaling pathway	P00627	ERK1-2	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P02738	De novo purine biosynthesis	P02902	ADP reductase	PSEAE|EnsemblGenome=PA1155|UniProtKB=Q9I4I2	Ribonucleoside-diphosphate reductase subunit beta	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=108059|UniProtKB=Q00262	Syntaxin-2	ISS	12737809	PubMed	PTHR19957:SF36	SYNTAXIN-2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	HUMAN|HGNC=10452|UniProtKB=P31350	Ribonucleoside-diphosphate reductase subunit M2	ISS			PTHR23409:SF20	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P02748	Isoleucine biosynthesis	P02997	Acetolactate synthase	RAT|RGD=1307988|UniProtKB=D4ACG2	IlvB (Bacterial acetolactate synthase)-like (Predicted), isoform CRA_c	ISS			PTHR18968:SF155	ACETOLACTATE SYNTHASE-LIKE PROTEIN
P00006	Apoptosis signaling pathway	P00318	PKCs	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Ensembl=ENSCAFG00000007780|UniProtKB=F1PZH9	Uncharacterized protein	ISS	12181435	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00020	FAS signaling pathway	P00615	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00029	Huntington disease	P00790	beta-Tubulin	CAEEL|WormBase=WBGene00006538|UniProtKB=P41937	Tubulin beta-4 chain	TAS	12932731	PubMed	PTHR11588:SF89	TUBULIN BETA-4 CHAIN
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	MOUSE|MGI=MGI=87994|UniProtKB=P05064	Fructose-bisphosphate aldolase A	ISS	4812352	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04586	ProTRH (Pro Thyrotropin-releasing Hormone)	BOVIN|Ensembl=ENSBTAG00000016138|UniProtKB=P01217	Glycoprotein hormones alpha chain	ISS			PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P00054	Toll receptor signaling pathway	P01341	Elk1	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	11050086	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00019	Endothelin signaling pathway	P00566	ERK	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	IGI	11707292	PubMed	PTHR24055:SF330	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	RAT|RGD=2736|UniProtKB=P35439	Glutamate receptor ionotropic, NMDA 1	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=1308054|UniProtKB=Q5XIS9	Serine/threonine-protein kinase D2	ISS	11062248	PubMed	PTHR22968:SF12	SERINE/THREONINE-PROTEIN KINASE D2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	TAS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DANRE|ZFIN=ZDB-GENE-041210-195|UniProtKB=F1R506	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00049	Parkinson disease	P01227	20S proteasome	DICPU|Gene=DICPUDRAFT_48337|UniProtKB=F0ZNQ2	Proteasome subunit alpha type (Fragment)	ISS	12859888	PubMed	PTHR11599:SF15	PROTEASOME SUBUNIT ALPHA TYPE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	HUMAN|HGNC=6698|UniProtKB=O75581	Low-density lipoprotein receptor-related protein 6	IDA	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P04393	Ras Pathway	P04552	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01161	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01202	p85	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P06664	Gonadotropin-releasing hormone receptor pathway	P06807	gnai	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00219	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS			PTHR24356:SF240	PROTEIN KINASE C
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04398	p53 pathway feedback loops 2	P04651	Ras	TAKRU|Ensembl=ENSTRUG00000005329|UniProtKB=H2SK54	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	HUMAN|HGNC=7778|UniProtKB=Q14934	Nuclear factor of activated T-cells, cytoplasmic 4	ISS	9462517	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MACMU|Ensembl=ENSMMUG00000006253|UniProtKB=F7H582	Uncharacterized protein	ISS	92357702	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05734	Synaptic vesicle trafficking	P05774	NSF	MONDO|Ensembl=ENSMODG00000011031|UniProtKB=F7F4B9	Uncharacterized protein	ISS	601633	OMIM	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	CHICK|Ensembl=ENSGALG00000028749|UniProtKB=Q5ZMQ2	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	IC	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00261	Bok	MACMU|Ensembl=ENSMMUG00000005661|UniProtKB=F6VX55	Bcl-2-related ovarian killer protein	ISS	9356461	PubMed	PTHR11256:SF48	BCL-2-RELATED OVARIAN KILLER PROTEIN
P00036	Interleukin signaling pathway	P00990	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00048	PI3 kinase pathway	P01188	Gbetagamma	PANTR|Ensembl=ENSPTRG00000007084|UniProtKB=H2Q9G5	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00011	Blood coagulation	P00418	Fibrin monomer	MACMU|Ensembl=ENSMMUG00000021302|UniProtKB=F6UZ87	Uncharacterized protein	ISS	11761631	gi	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	DROME|FlyBase=FBgn0001991|UniProtKB=Q24270	Voltage-dependent calcium channel type D subunit alpha-1	IC	15737619	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01407	Erk	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00010	B cell activation	P00383	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04398	p53 pathway feedback loops 2	P04665	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05754	Ggamma	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MACMU|Ensembl=ENSMMUG00000002134|UniProtKB=F6UNV6	Ribosomal protein S6 kinase	ISS	10480933	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	ARATH|TAIR=AT3G60250|UniProtKB=O81275	Casein kinase II subunit beta-3	IDA	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-040718-134|UniProtKB=Q6DH55	Guanine nucleotide binding protein (G protein), beta polypeptide 3, like	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	TAS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04395	Vasopressin synthesis	P04592	Exopeptidase	PANTR|Gene=CPE|UniProtKB=A5A6K7	Carboxypeptidase E	ISS	1778303	PubMed	PTHR11532:SF59	CARBOXYPEPTIDASE E
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04396	Vitamin D metabolism and pathway	P04602	RXR	HUMAN|HGNC=3534|UniProtKB=P05160	Coagulation factor XIII B chain	TAS			PTHR19325:SF314	COAGULATION FACTOR XIII B CHAIN
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00752	cGMP-gated ion channel	CHICK|Ensembl=ENSGALG00000016749|UniProtKB=F1NEW7	Uncharacterized protein	IDA	12432397	PubMed	PTHR10217:SF390	CYCLIC NUCLEOTIDE-GATED CATION CHANNEL ALPHA-3
P02773	S-adenosylmethionine biosynthesis	P03142	Cobalamin-dependent homocysteine transmethylase	THEMA|EnsemblGenome=TM_0268|UniProtKB=Q9WYA5	5-methyltetrahydrofolate S-homocysteine methyltransferase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	ANOGA|EnsemblGenome=AGAP010172|UniProtKB=Q7PD38	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00566	ERK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00059	p53 pathway	P01486	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00808	Caspase 8	CHICK|Ensembl=ENSGALG00000008355|UniProtKB=F1NXP6	Uncharacterized protein	IDA	11788820	PubMed	PTHR10454:SF162	CASPASE-8
P04393	Ras Pathway	P04552	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00021	FGF signaling pathway	P00624	14-3-3	USTMA|Gene=UMAG_01366|UniProtKB=A0A0D1E7J2	Chromosome 2, whole genome shotgun sequence	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	BOVIN|Ensembl=ENSBTAG00000007591|UniProtKB=Q95KV1	Inhibitor of nuclear factor kappa-B kinase subunit alpha	RCA			PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01202	p85	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	IGI	12701063	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00011	Blood coagulation	P00406	Fibrinogen	HUMAN|HGNC=3661|UniProtKB=P02671	Fibrinogen alpha chain	ISS	4503689	gi	PTHR19143:SF232	FIBRINOGEN ALPHA CHAIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	ORNAN|Ensembl=ENSOANG00000006415|UniProtKB=F6WIC7	Uncharacterized protein	ISS			PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	XENTR|Xenbase=XB-GENE-854877|UniProtKB=F7C949	Presenilin	ISS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00010	B cell activation	P00384	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00547	PP2A	MONDO|Ensembl=ENSMODG00000014177|UniProtKB=F6U7A6	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00243	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04559	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06707	FAK	MOUSE|MGI=MGI=95481|UniProtKB=P34152	Focal adhesion kinase 1	RCA	9182576	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00018	EGF receptor signaling pathway	P00561	STAT	MACMU|Ensembl=ENSMMUG00000010705|UniProtKB=F7G8V4	Signal transducer and activator of transcription	ISS	95188889	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00018	EGF receptor signaling pathway	P00564	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00010	B cell activation	P00371	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00968	Ikk	CANLF|Ensembl=ENSCAFG00000009588|UniProtKB=E2RNA9	Uncharacterized protein	ISS	12813046	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IDA	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00023	General transcription regulation	P00660	RNA Polymerase II	MONDO|Ensembl=ENSMODG00000002570|UniProtKB=F7GF94	Uncharacterized protein	ISS	606023	OMIM	PTHR10917:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00012	Cadherin signaling pathway	P00477	GSK3beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	ARATH|TAIR=AT5G19010|UniProtKB=Q8W4J2	Mitogen-activated protein kinase 16	TAS			PTHR24055:SF211	MITOGEN-ACTIVATED PROTEIN KINASE 16
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	MACMU|Ensembl=ENSMMUG00000001758|UniProtKB=F6TN15	Uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF84	CASEIN KINASE I ISOFORM ALPHA
P00010	B cell activation	P00371	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00648	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00020	FAS signaling pathway	P00609	FAF1	HUMAN|HGNC=3578|UniProtKB=Q9UNN5	FAS-associated factor 1	IGI	8524870	PubMed	PTHR23322:SF52	FAS-ASSOCIATED FACTOR 1
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	DANRE|ZFIN=ZDB-GENE-051202-2|UniProtKB=Q6ZM67	Uncharacterized protein	ISS	92049750	PubMed	PTHR44391:SF3	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00761	Truncated Htt	MACMU|Ensembl=ENSMMUG00000008392|UniProtKB=F6VQZ3	Uncharacterized protein	ISS	9462744	PubMed	PTHR10170:SF10	HUNTINGTIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00021	FGF signaling pathway	P00642	MEK1-2	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000017387|UniProtKB=E2RLD1	Uncharacterized protein	ISS	129387	gi	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	1171954	gi	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00046	Oxidative stress response	P01135	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	TAS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04552	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IDA	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00022	General transcription by RNA polymerase I	P00650	TAF-IB	ARATH|TAIR=AT4G34340|UniProtKB=Q9SYZ9	Transcription initiation factor TFIID subunit 8	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00004	Alzheimer disease-presenilin pathway	P00172	BACE-1	MONDO|Ensembl=ENSMODG00000013692|UniProtKB=F6QP52	Uncharacterized protein	ISS	10956649	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00056	VEGF signaling pathway	P01413	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01143	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04393	Ras Pathway	P04556	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	DANRE|ZFIN=ZDB-GENE-050417-59|UniProtKB=Q15KE4	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05949	Grb2	XENTR|Xenbase=XB-GENE-6070000|UniProtKB=Q66II3	Growth factor receptor-bound protein 2	ISS	11384839	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P05918	p38 MAPK pathway	P06017	MNK2	MOUSE|MGI=MGI=894279|UniProtKB=Q8CDB0	MAP kinase-interacting serine/threonine-protein kinase 2	ISS	9155017	PubMed	PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	TAS	12655147	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01134	cPLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	TAS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00034	Integrin signalling pathway	P00927	Rac	ENTHI|EnsemblGenome=EHI_197840|UniProtKB=C4M8K6	Rho family GTPase	IGI	4757952	gi	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	TAS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00034	Integrin signalling pathway	P00925	MEK	CHICK|Ensembl=ENSGALG00000001001|UniProtKB=F1P3T1	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00050	Plasminogen activating cascade	P01247	TAFI	PANTR|Ensembl=ENSPTRG00000005852|UniProtKB=H2Q7J0	Uncharacterized protein	ISS			PTHR11705:SF17	CARBOXYPEPTIDASE B2
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00034	Integrin signalling pathway	P00919	Arf6	MONDO|Ensembl=ENSMODG00000023914|UniProtKB=F7FYA6	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00036	Interleukin signaling pathway	P00973	PKB	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04393	Ras Pathway	P04558	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00020	FAS signaling pathway	P00612	Fas	MOUSE|MGI=MGI=95484|UniProtKB=P25446	Tumor necrosis factor receptor superfamily member 6	TAS	14585074	PubMed	PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P00020	FAS signaling pathway	P00615	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00019	Endothelin signaling pathway	P00591	PLCbeta	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00029	Huntington disease	P00807	Actin	LEIMA|EnsemblGenome=LmjF.04.1230|UniProtKB=Q9U1E8	Actin	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00048	PI3 kinase pathway	P01179	PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	TAKRU|Ensembl=ENSTRUG00000005300|UniProtKB=H2SJZ5	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176910	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00054	Toll receptor signaling pathway	P01358	ERK1	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	93028473	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000002647|UniProtKB=F7DIB7	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000019407|UniProtKB=H2QUY0	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01443	Phospholipase C	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	IDA	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	HUMAN|HGNC=4597|UniProtKB=P41594	Metabotropic glutamate receptor 5	ISS	9407094	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	PANTR|Ensembl=ENSPTRG00000019407|UniProtKB=H2QUY0	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P00021	FGF signaling pathway	P00629	PP2A	DANRE|ZFIN=ZDB-GENE-040426-877|UniProtKB=F1Q6Z7	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05915	Opioid proenkephalin pathway	P05994	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00005	Angiogenesis	P00256	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01173	STAT	MOUSE|MGI=MGI=103038|UniProtKB=P42227	Signal transducer and activator of transcription 3	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00034	Integrin signalling pathway	P00924	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00965	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	IC	98269030	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01169	Vav	PANTR|Ensembl=ENSPTRG00000010378|UniProtKB=H2QF58	Uncharacterized protein	ISS	10661401	PubMed	PTHR22826:SF112	PROTO-ONCOGENE VAV
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	PANTR|Ensembl=ENSPTRG00000013428|UniProtKB=H2QK88	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF358	MYOSIN-7B
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02738	De novo purine biosynthesis	P02905	Amidophosphoribosyl transferase	PANTR|Ensembl=ENSPTRG00000016080|UniProtKB=H2QPI4	Amidophosphoribosyltransferase	ISS			PTHR11907:SF18	AMIDOPHOSPHORIBOSYLTRANSFERASE
P00034	Integrin signalling pathway	P00951	Jnk	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00005	Angiogenesis	P00194	Paxillin	XENTR|Xenbase=XB-GENE-941407|UniProtKB=F7B727	Peroxidasin	ISS	7579684	PubMed	PTHR24216:SF11	PAXILLIN
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	15572354	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00470	F-actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g169611|UniProtKB=A7SEB1	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00052	TGF-beta signaling pathway	P01284	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04397	p53 pathway by glucose deprivation	P04641	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00322	Cytochrome C	ORNAN|Ensembl=ENSOANG00000009156|UniProtKB=F7EJM9	Uncharacterized protein	ISS	5846985	PubMed	PTHR11961:SF12	CYTOCHROME C
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	BOVIN|Ensembl=ENSBTAG00000004279|UniProtKB=P61585	Transforming protein RhoA	ISS	12169092	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P06587	Nicotine pharmacodynamics pathway	P06608	DDC	MOUSE|MGI=MGI=94876|UniProtKB=O88533	Aromatic-L-amino-acid decarboxylase	TAS	7567987	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P06664	Gonadotropin-releasing hormone receptor pathway	P06785	ELK1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	RCA	11279280	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=2443376|UniProtKB=Q8BIZ0	Protocadherin-20	ISS	8120095	PubMed	PTHR43912:SF7	PROTOCADHERIN-20
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	ISS			PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	TAS	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DROME|FlyBase=FBgn0003093|UniProtKB=P13678	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00053	T cell activation	P01322	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00018	EGF receptor signaling pathway	P00543	ERK1-2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	MOUSE|MGI=MGI=1351342|UniProtKB=Q3UVX5	Metabotropic glutamate receptor 5	ISS	7476890	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00565	PKC	YEAST|SGD=S000000201|UniProtKB=P24583	Protein kinase C-like 1	IGI	125549	gi	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00004	Alzheimer disease-presenilin pathway	P00114	actin	SCHMA|EnsemblGenome=Smp_183710|UniProtKB=G4VLW1	Putative actin	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00810	GAPDH	DICDI|dictyBase=DDB_G0275153|UniProtKB=Q94469	Glyceraldehyde-3-phosphate dehydrogenase	IPI			PTHR10836:SF52	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	DANRE|ZFIN=ZDB-GENE-000330-9|UniProtKB=Q90ZE4	Presenilin-2	TAS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P04393	Ras Pathway	P04567	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01455	Smad4	TAKRU|Ensembl=ENSTRUG00000014344|UniProtKB=H2UI95	Mothers against decapentaplegic homolog	ISS	12736218	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00019	Endothelin signaling pathway	P00591	PLCbeta	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00059	p53 pathway	G01568	KILLER/DR5	HUMAN|HGNC=11904|UniProtKB=O00220	Tumor necrosis factor receptor superfamily member 10A	IGI	10594023	PubMed	PTHR23097:SF179	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10A
P00019	Endothelin signaling pathway	P00567	PKG	DANRE|ZFIN=ZDB-GENE-080225-40|UniProtKB=F1R125	Uncharacterized protein	ISS	14568994	PubMed	PTHR24353:SF68	SUBFAMILY NOT NAMED
P02738	De novo purine biosynthesis	P02902	ADP reductase	CANLF|Ensembl=ENSCAFG00000003409|UniProtKB=E2R7H9	Uncharacterized protein	ISS			PTHR23409:SF20	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00702	CPB	RAT|RGD=620218|UniProtKB=P15337	Cyclic AMP-responsive element-binding protein 1	ISS			PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	XENTR|Xenbase=XB-GENE-6050844|UniProtKB=F6WNJ9	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00018	EGF receptor signaling pathway	P00543	ERK1-2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00038	JAK/STAT signaling pathway	P01034	Jak	HUMAN|HGNC=6190|UniProtKB=P23458	Tyrosine-protein kinase JAK1	ISS	11929133	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MACMU|Ensembl=ENSMMUG00000017431|UniProtKB=F7HPP3	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	TAKRU|Ensembl=ENSTRUG00000013411|UniProtKB=H2UB84	Uncharacterized protein	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00007	Axon guidance mediated by semaphorins	P00328	plexinB1	CANLF|Ensembl=ENSCAFG00000012685|UniProtKB=E2RM56	Uncharacterized protein	ISS			PTHR22625:SF36	PLEXIN-B1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	TAS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00036	Interleukin signaling pathway	P00990	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000015178|UniProtKB=F6WI86	Neural cadherin	ISS	8120095	PubMed	PTHR24027:SF79	CADHERIN-2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04395	Vasopressin synthesis	P04596	Endo Peptidase	DROME|FlyBase=FBgn0032242|UniProtKB=Q9VKW5	CG5355	IC	9695945	PubMed	PTHR42881:SF2	PROLYL ENDOPEPTIDASE
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00017	DNA replication	P00527	Histones	PUCGT|EnsemblGenome=PGTG_01862|UniProtKB=E3JT42	Histone H3	ISS	12413958	PubMed	PTHR11426:SF47	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01414	PLC-gamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g188243|UniProtKB=A7SCN8	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CHICK|Ensembl=ENSGALG00000000059|UniProtKB=F1NMU4	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00059	p53 pathway	P04630	PP2A	MONDO|Ensembl=ENSMODG00000019001|UniProtKB=F7CP86	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05915	Opioid proenkephalin pathway	P05994	G-protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	ISS	1482697	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00053	T cell activation	P01324	rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	IDA	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00019	Endothelin signaling pathway	P00568	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00006	Apoptosis signaling pathway	P00274	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	IC	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	SCHMA|EnsemblGenome=Smp_046600|UniProtKB=G4VLW2	Putative actin-1	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00034	Integrin signalling pathway	P00941	Integrin alpha	CANLF|Ensembl=ENSCAFG00000014145|UniProtKB=F1PRU9	Uncharacterized protein	IPI	5733734	gi	PTHR23220:SF73	INTEGRIN ALPHA-IIB
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	TAKRU|Ensembl=ENSTRUG00000013411|UniProtKB=H2UB84	Uncharacterized protein	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	6264430	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00053	T cell activation	P01312	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00020	FAS signaling pathway	P00615	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00046	Oxidative stress response	P01135	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02738	De novo purine biosynthesis	P02891	GDP kinase	METAC|EnsemblGenome=MA_1524|UniProtKB=Q8TQL6	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=621089|UniProtKB=F1LMI3	Cadherin 3, type 1, P-cadherin (Placental)	ISS	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00006	Apoptosis signaling pathway	P00269	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00647	SHP2	MOUSE|MGI=MGI=99511|UniProtKB=P35235	Tyrosine-protein phosphatase non-receptor type 11	IPI	14525967	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04393	Ras Pathway	P04578	Rho	XENTR|Xenbase=XB-GENE-941426|UniProtKB=Q28HZ4	Novel Rho protein	ISS	10556059	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00053	T cell activation	P01312	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00059	p53 pathway	G01568	KILLER/DR5	HUMAN|HGNC=11905|UniProtKB=O14763	Tumor necrosis factor receptor superfamily member 10B	IGI	11498783	PubMed	PTHR23097:SF88	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10B
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04542	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	PANTR|Ensembl=ENSPTRG00000007084|UniProtKB=H2Q9G5	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	CHICK|Ensembl=ENSGALG00000008512|UniProtKB=F1P0S6	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DANRE|ZFIN=ZDB-GENE-030131-1229|UniProtKB=Q6DHS1	Actin, alpha 2, smooth muscle, aorta	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00014	Cholesterol biosynthesis	P00496	Diphosphomevalonate decarboxylase	PANTR|Ensembl=ENSPTRG00000008459|UniProtKB=H2QBQ1	Mevalonate (Diphospho) decarboxylase	ISS	P53602	SPACC	PTHR10977:SF3	DIPHOSPHOMEVALONATE DECARBOXYLASE
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	PANTR|Ensembl=ENSPTRG00000013825|UniProtKB=H2RAK4	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00053	T cell activation	P01336	Jnk	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	P01472	Histone deacetylase	BOVIN|Ensembl=ENSBTAG00000012698|UniProtKB=Q32PJ8	Histone deacetylase 1	ISS	10485845	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P00046	Oxidative stress response	P01131	MKP5	MOUSE|MGI=MGI=1927168|UniProtKB=Q9JLY7	Dual specificity protein phosphatase 14	ISS			PTHR10159:SF338	DUAL SPECIFICITY PROTEIN PHOSPHATASE 14
P00049	Parkinson disease	P01211	ERK	RAT|RGD=621505|UniProtKB=P0C865	Mitogen-activated protein kinase 7	ISS	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00009	Axon guidance mediated by netrin	P00363	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00046	Oxidative stress response	P01135	p38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00003	Alzheimer disease-amyloid secretase pathway	P00107	kinesin	CANLF|Ensembl=ENSCAFG00000018285|UniProtKB=E2RAF0	Uncharacterized protein	ISS	11740561	PubMed	PTHR19959:SF203	KINESIN LIGHT CHAIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DANRE|ZFIN=ZDB-GENE-041210-195|UniProtKB=F1R506	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00049	Parkinson disease	P01211	ERK	RAT|RGD=621505|UniProtKB=P0C865	Mitogen-activated protein kinase 7	ISS	12912994	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00052	TGF-beta signaling pathway	P01284	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00012	Cadherin signaling pathway	P00477	GSK3beta	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04393	Ras Pathway	P04542	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05731	GABA-B receptor II signaling	P05752	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	RCA	91298951	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00643	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	MOUSE|MGI=MGI=88296|UniProtKB=O55017	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	11976940	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	PANTR|Ensembl=ENSPTRG00000006786|UniProtKB=H2Q908	Uncharacterized protein	ISS			PTHR11618:SF4	TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT
P00005	Angiogenesis	P00249	PAK	PANTR|Ensembl=ENSPTRG00000015787|UniProtKB=H2QP14	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P05913	Enkephalin release	P05972	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00012	Cadherin signaling pathway	P00470	F-actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g234494|UniProtKB=A7RU31	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IDA	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MACMU|Ensembl=ENSMMUG00000003405|UniProtKB=F7FE85	Uncharacterized protein	ISS	12356903	PubMed	PTHR10201:SF143	MATRILYSIN
P02783	Tryptophan biosynthesis	P03210	Indole-3-glycerol phosphate synthase	DEIRA|EnsemblGenome=DR_1426|UniProtKB=Q9RUG0	Indole-3-glycerol phosphate synthase	ISS			PTHR22854:SF2	TRYPTOPHAN BIOSYNTHESIS PROTEIN TRPCF
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=1261834|UniProtKB=O70283	Protein Wnt-2b	IDA	11266476	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00018	EGF receptor signaling pathway	P00559	MEK1-2	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IGI	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00019	Endothelin signaling pathway	P00567	PKG	PANTR|Ensembl=ENSPTRG00000002509|UniProtKB=H2Q1X0	cGMP-dependent protein kinase	ISS	12855709	PubMed	PTHR24353:SF68	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MACMU|Ensembl=ENSMMUG00000017683|UniProtKB=F6UA63	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P05913	Enkephalin release	P05974	G-Protein (i)	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CAEBR|Gene=CBG17587|UniProtKB=A8XRA5	Phosphoinositide phospholipase C	ISS			PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00054	Toll receptor signaling pathway	P01369	MKK1	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05913	Enkephalin release	P05972	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00024	Glycolysis	P00675	Pyruvate kinase	MOUSE|MGI=MGI=97591|UniProtKB=P52480	Pyruvate kinase PKM	RCA			PTHR11817:SF15	PYRUVATE KINASE PKM
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	CAEEL|WormBase=WBGene00013866|UniProtKB=G5EFH8	Cystathionine Beta-Synthase	ISS			PTHR10314:SF8	CYSTATHIONINE BETA-SYNTHASE-RELATED
P00034	Integrin signalling pathway	P00916	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IPI	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	P01438	PP2A	BOVIN|Ensembl=ENSBTAG00000007061|UniProtKB=Q08DP7	Protein phosphatase 2, regulatory subunit B', beta isoform	ISS	11531413	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00035	Interferon-gamma signaling pathway	P00952	Jak2	MACMU|Ensembl=ENSMMUG00000014558|UniProtKB=F7GT47	Tyrosine-protein kinase	ISS	22482294	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00057	Wnt signaling pathway	P01444	Wnt	RAT|RGD=69079|UniProtKB=M0R9D3	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MOUSE|MGI=MGI=2444552|UniProtKB=Q8BFZ3	Beta-actin-like protein 2	IC	10974003	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00023	General transcription regulation	P00667	TFIIFbeta	MACMU|Ensembl=ENSMMUG00000012634|UniProtKB=F7F069	General transcription factor IIF subunit 2	ISS			PTHR10445:SF0	GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	SCHPO|PomBase=SPAC23H4.06|UniProtKB=Q09179	Glutamine synthetase	ISS			PTHR20852:SF57	GLUTAMINE SYNTHETASE 2 CYTOPLASMIC
P00029	Huntington disease	P00790	beta-Tubulin	MONDO|Ensembl=ENSMODG00000017213|UniProtKB=F6WYK8	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	TAS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00034	Integrin signalling pathway	P00906	Rap1	CHICK|Ensembl=ENSGALG00000016889|UniProtKB=E1BQI2	Uncharacterized protein	ISS	8576107	PubMed	PTHR24070:SF221	RAS-RELATED PROTEIN RAP-2A
P00047	PDGF signaling pathway	P01148	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8479536	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ORNAN|Ensembl=ENSOANG00000000460|UniProtKB=F7F4W9	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00034	Integrin signalling pathway	P00948	Rho	BOVIN|Ensembl=ENSBTAG00000046054|UniProtKB=Q3ZBW5	Rho-related GTP-binding protein RhoB	ISS	11973360	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	TAS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04393	Ras Pathway	P04552	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00029	Huntington disease	P00780	Microtubule	EMENI|EnsemblGenome=CADANIAG00007636|UniProtKB=P10874	Tubulin beta-2 chain	IDA	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00059	p53 pathway	P04611	P300	BOVIN|Ensembl=ENSBTAG00000016198|UniProtKB=E1B8D6	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00053	T cell activation	P01331	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00034	Integrin signalling pathway	P00928	alpha actinin	MACMU|Ensembl=ENSMMUG00000006429|UniProtKB=F7HU82	Alpha-actinin-4	ISS	2116421	PubMed	PTHR43947:SF7	ALPHA-ACTININ-4
P05913	Enkephalin release	P05978	AC	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P04393	Ras Pathway	P04551	RalGDS	RAT|RGD=3533|UniProtKB=Q03386	Ral guanine nucleotide dissociation stimulator	IDA	8094051	PubMed	PTHR23113:SF35	RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	RAT|RGD=2735|UniProtKB=Q63273	Glutamate receptor ionotropic, kainate 5	ISS	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P02743	Formyltetrahydroformate biosynthesis	P02958	Dihydrofolate synthase	ORYSJ|EnsemblGenome=OS10G0503200|UniProtKB=Q337F3	Dihydrofolate synthetase/folylpolyglutamate synthetase, putative, expressed	ISS			PTHR11136:SF6	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000002016|UniProtKB=F1P3G1	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00015	Circadian clock system	G01503	per	HUMAN|HGNC=8845|UniProtKB=O15534	Period circadian protein homolog 1	IDA	20570170	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00056	VEGF signaling pathway	P01418	Paxillin	DICDI|dictyBase=DDB_G0274109|UniProtKB=Q8MML5	Paxillin-B	ISS	7579684	PubMed	PTHR24216:SF47	PAXILLIN-B
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00029	Huntington disease	P00774	Dynein complex	MACMU|Ensembl=ENSMMUG00000011268|UniProtKB=F6WNX7	Uncharacterized protein	ISS	9454836	PubMed	PTHR12688:SF1	CYTOPLASMIC DYNEIN 1 LIGHT INTERMEDIATE CHAIN 2
P02763	Peptidoglycan biosynthesis	P03091	D-alanine-D-alanine ligase	BACSU|EnsemblGenome=BSU04560|UniProtKB=P96612	D-alanine--D-alanine ligase	ISS			PTHR23132:SF8	D-ALANINE--D-ALANINE LIGASE A
P00034	Integrin signalling pathway	P00920	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00056	VEGF signaling pathway	P01407	Erk	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	XENTR|Xenbase=XB-GENE-976753|UniProtKB=Q0VFR6	Syntaxin 1A (Brain)	ISS	12624525	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01332	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	YEAST|SGD=S000005738|UniProtKB=P18851	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	RCA	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00586	Gq	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DANRE|ZFIN=ZDB-GENE-030131-6503|UniProtKB=Q7ZUC5	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF297	PROTEIN KINASE C DELTA TYPE
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00059	p53 pathway	P01486	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00034	Integrin signalling pathway	P00947	Laminin	MACMU|Ensembl=ENSMMUG00000013782|UniProtKB=F6PZI2	Uncharacterized protein	ISS	2538453	PubMed	PTHR44537:SF1	LAMININ SUBUNIT ALPHA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	ARATH|TAIR=AT5G63310|UniProtKB=O64903	Nucleoside diphosphate kinase II, chloroplastic	ISS			PTHR11349:SF44	NUCLEOSIDE DIPHOSPHATE KINASE II, CHLOROPLASTIC
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	LEIMA|EnsemblGenome=LmjF.35.4010|UniProtKB=Q9GNR4	Protein kinase A catalytic subunit isoform 1	ISS	10553940	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01438	PP2A	CANLF|Ensembl=ENSCAFG00000014047|UniProtKB=F1PV54	Uncharacterized protein	ISS	96161994	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P00025	Hedgehog signaling pathway	P00691	CBP	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	TAKRU|Ensembl=ENSTRUG00000007253|UniProtKB=H2SZQ1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P05731	GABA-B receptor II signaling	P05754	Ggamma	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	RCA	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	TAS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P02738	De novo purine biosynthesis	P02909	GDP reductase	HALSA|EnsemblGenome=VNG_1644G|UniProtKB=Q9HPG8	Ribonucleoside reductase large chain	ISS			PTHR43371:SF1	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00021	FGF signaling pathway	P00632	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01189	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	IDA	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00021	FGF signaling pathway	P00632	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	IGI	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00899	IRS 1-4	MACMU|Ensembl=ENSMMUG00000021790|UniProtKB=F7DE94	Uncharacterized protein	ISS	5031805	gi	PTHR10614:SF7	INSULIN RECEPTOR SUBSTRATE 2
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	DANRE|ZFIN=ZDB-GENE-990415-257|UniProtKB=O42376	Mitogen-activated protein kinase 12	ISS	11274345	PubMed	PTHR24055:SF339	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00019	Endothelin signaling pathway	P00575	furin	HUMAN|HGNC=8568|UniProtKB=P09958	Furin	ISS	95328031	PubMed	PTHR42884:SF1	FURIN
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	PANTR|Ensembl=ENSPTRG00000001751|UniProtKB=H2Q0Q5	Glutamine synthetase	ISS			PTHR20852:SF45	GLUTAMINE SYNTHETASE
P00010	B cell activation	P00391	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00025	Hedgehog signaling pathway	P00692	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00011	Blood coagulation	P00437	Kallikrein	MACMU|Ensembl=ENSMMUG00000011633|UniProtKB=F6PJA8	Uncharacterized protein	ISS	4504877	gi	PTHR44459:SF2	PLASMA KALLIKREIN
P05918	p38 MAPK pathway	P06016	HSP27	PANTR|Ensembl=ENSPTRG00000019319|UniProtKB=H2QUT1	Heat shock 27kDa protein 1	ISS	8280084	PubMed	PTHR11527:SF114	HEAT SHOCK PROTEIN BETA-1
P05915	Opioid proenkephalin pathway	P05988	peptide E	XENTR|Xenbase=XB-GENE-942760|UniProtKB=F6Y5F6	Uncharacterized protein	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00053	T cell activation	P01318	PKC-theta	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00010	B cell activation	P00384	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00013	Cell cycle	P00480	Proteasome	ORNAN|Ensembl=ENSOANG00000008054|UniProtKB=F7CV41	Uncharacterized protein	ISS	9426256	PubMed	PTHR10855:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00030	Hypoxia response via HIF activation	P00824	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00025	Hedgehog signaling pathway	P00690	Cubitus interruptus	DANRE|ZFIN=ZDB-GENE-041111-162|UniProtKB=F1QSH8	Uncharacterized protein	ISS	10976059	PubMed	PTHR19818:SF5	TRANSCRIPTIONAL ACTIVATOR GLI3
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	RAT|RGD=2343|UniProtKB=P08483	Muscarinic acetylcholine receptor M3	TAS	11166329	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00053	T cell activation	P01323	I kappa B	HUMAN|HGNC=7797|UniProtKB=P25963	NF-kappa-B inhibitor alpha	ISS	14665694	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P02746	Heme biosynthesis	P02982	Protoheme IX farnesyl transferase	SYNY3|EnsemblGenome=BAA18181|UniProtKB=Q79EF2	Protoheme IX farnesyltransferase	ISS			PTHR43448:SF2	PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL
P02728	Arginine biosynthesis	P02846	Ornithine carbamoyl transferase	PSEAE|EnsemblGenome=PA5172|UniProtKB=P08308	Ornithine carbamoyltransferase, catabolic	ISS			PTHR11405:SF44	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01408	Akt/PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04633	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01318	PKC-theta	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	MONDO|Ensembl=ENSMODG00000008889|UniProtKB=F7BRY9	Serine/threonine-protein kinase receptor	ISS	9395284	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MOUSE|MGI=MGI=95790|UniProtKB=Q01776	Gonadotropin-releasing hormone receptor	IDA			PTHR24241:SF22	GONADOTROPIN-RELEASING HORMONE RECEPTOR
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IDA	188830	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00778	NMDA receptor	CANLF|Gene=GRIN1|UniProtKB=Q5R1P0	Glutamate receptor ionotropic, NMDA 1	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00010	B cell activation	P00381	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00547	PP2A	MOUSE|MGI=MGI=1321161|UniProtKB=P62715	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P02773	S-adenosylmethionine biosynthesis	P03142	Cobalamin-dependent homocysteine transmethylase	MACMU|Ensembl=ENSMMUG00000010073|UniProtKB=F6T0P5	Uncharacterized protein	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P00059	p53 pathway	P04630	PP2A	MONDO|Ensembl=ENSMODG00000014177|UniProtKB=F6U7A6	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	TAKRU|Ensembl=ENSTRUG00000007989|UniProtKB=P68140	Actin, alpha skeletal muscle A	ISS	11889126	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P06587	Nicotine pharmacodynamics pathway	P06604	SLC18A2	PANTR|Ensembl=ENSPTRG00000002979|UniProtKB=H2Q2M8	Uncharacterized protein	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00053	T cell activation	P01324	rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	10891487	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	IC	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00059	p53 pathway	P01486	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00373	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IGI	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00047	PDGF signaling pathway	P01150	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00927	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	10540223	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00053	T cell activation	P01311	Raf	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	IDA	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00057	Wnt signaling pathway	P01440	Cadherin	BOVIN|Ensembl=ENSBTAG00000012518|UniProtKB=F6Q0C0	Uncharacterized protein	ISS	8120095	PubMed	PTHR43912:SF3	PROTOCADHERIN-1
P02769	Purine metabolism	P03116	Xanthine Oxidase	DROME|FlyBase=FBgn0003308|UniProtKB=P10351	Xanthine dehydrogenase	ISS	2493563	PubMed	PTHR11908:SF100	XANTHINE DEHYDROGENASE
P00005	Angiogenesis	P00209	FAK	DANRE|ZFIN=ZDB-GENE-020114-1|UniProtKB=F1QT14	Uncharacterized protein	ISS	12640026	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P02740	De novo pyrimidine ribonucleotides biosythesis	P02927	Dihydrooratate oxidase	BACSU|EnsemblGenome=BSU15540|UniProtKB=P25996	Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit	ISS			PTHR43843:SF1	DIHYDROOROTATE DEHYDROGENASE  FUMARATE
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	HUMAN|HGNC=6026|UniProtKB=P25024	C-X-C chemokine receptor type 1	IC	6753456	gi	PTHR10489:SF916	C-X-C CHEMOKINE RECEPTOR TYPE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00019	Endothelin signaling pathway	P00586	Gq	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00012	Cadherin signaling pathway	P00470	F-actin	ORNAN|Ensembl=ENSOANG00000007581|UniProtKB=F6QWB7	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	ISS	11035810	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00056	VEGF signaling pathway	P01417	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00053	T cell activation	P01299	TCR Beta	MACMU|Ensembl=ENSMMUG00000030070|UniProtKB=G7MMY5	Uncharacterized protein (Fragment)	IDA			PTHR23268:SF53	SUBFAMILY NOT NAMED
P02751	Lysine biosynthesis	P03009	Aspartokinase	SCHPO|PomBase=SPBC776.03|UniProtKB=O94671	Probable homoserine dehydrogenase	ISS			PTHR43070:SF3	HOMOSERINE DEHYDROGENASE
P05915	Opioid proenkephalin pathway	P05994	G-protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	ISS	8170357	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00048	PI3 kinase pathway	P01179	PKB	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00775	Rac	HUMAN|HGNC=1736|UniProtKB=P60953	Cell division control protein 42 homolog	TAS			PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00019	Endothelin signaling pathway	P00575	furin	PANTR|Ensembl=ENSPTRG00000007461|UniProtKB=H2QA34	Furin (Paired basic amino acid cleaving enzyme)	ISS	11861638	PubMed	PTHR42884:SF1	FURIN
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	HUMAN|HGNC=1402|UniProtKB=Q08289	Voltage-dependent L-type calcium channel subunit beta-2	IC	20088160	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00005	Angiogenesis	P00181	SHP2	MOUSE|MGI=MGI=99511|UniProtKB=P35235	Tyrosine-protein phosphatase non-receptor type 11	ISS	14534538	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P05918	p38 MAPK pathway	P06042	4E-BP1	HUMAN|HGNC=3288|UniProtKB=Q13541	Eukaryotic translation initiation factor 4E-binding protein 1	RCA	12820960	PubMed	PTHR12669:SF14	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	RAT|RGD=2744|UniProtKB=P31422	Metabotropic glutamate receptor 3	ISS	9407094	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00924	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00045	Notch signaling pathway	P01103	Next	BOVIN|Ensembl=ENSBTAG00000012817|UniProtKB=E1BDN7	Delta-like protein	ISS	12826675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00057	Wnt signaling pathway	P01435	SWI/SNF	CHICK|Ensembl=ENSGALG00000005983|UniProtKB=Q5ZK40	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1	ISS	11532957	PubMed	PTHR10019:SF5	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY B MEMBER 1
P00034	Integrin signalling pathway	P00925	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00059	p53 pathway	P04609	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00206	Wnt	MONDO|Ensembl=ENSMODG00000015792|UniProtKB=Q2QL96	Protein Wnt-2	ISS	8717036	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Ensembl=ENSGALG00000009844|UniProtKB=P68034	Actin, alpha cardiac muscle 1	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00010	B cell activation	P00381	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=11438|UniProtKB=Q13277	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P04398	p53 pathway feedback loops 2	P04651	Ras	DAPPU|EnsemblGenome=DAPPUDRAFT_301818|UniProtKB=E9I1I7	Putative uncharacterized protein	ISS	10684567	PubMed	PTHR24070:SF385	GTPASE HRAS
P00034	Integrin signalling pathway	P00920	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00053	T cell activation	P01305	Calmodulin	MACMU|Ensembl=ENSMMUG00000028962|UniProtKB=F7EWG5	Uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF322	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00643	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	IC	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00005	Angiogenesis	P00243	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	ARATH|TAIR=AT4G28540|UniProtKB=Q8LPJ1	Casein kinase 1-like protein 6	IDA	11437445	PubMed	PTHR11909:SF114	ADK1-RELATED
P00018	EGF receptor signaling pathway	P00557	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00805	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04393	Ras Pathway	P04546	GSK3	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00010	B cell activation	P00385	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05730	Endogenous cannabinoid signaling	P05751	Galpha	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	RCA	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00046	Oxidative stress response	P01122	TRX	SCHPO|PomBase=SPAC7D4.07c|UniProtKB=O14463	Thioredoxin-1	ISS			PTHR10438:SF360	THIOREDOXIN H9-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000014675|UniProtKB=H2QM57	Phosphoinositide phospholipase C	ISS			PTHR10336:SF84	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	LEIMA|EnsemblGenome=LmjF.18.1080|UniProtKB=Q27687	Protein kinase A catalytic subunit	IC	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04375	5HT3 type receptor mediated signaling pathway	P04421	5HT transporter	BOVIN|Gene=SLC6A4|UniProtKB=Q9XT49	Sodium-dependent serotonin transporter	ISS	7681602	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P00012	Cadherin signaling pathway	P00470	F-actin	BOVIN|Ensembl=ENSBTAG00000005714|UniProtKB=Q3ZC07	Actin, alpha cardiac muscle 1	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04456	ProCRF (Pro Corticotropin-Releasing Factor)	MACMU|Ensembl=ENSMMUG00000021587|UniProtKB=F7E8Q2	Uncharacterized protein	ISS	122560	OMIM	PTHR15035:SF9	CORTICOLIBERIN
P04393	Ras Pathway	P04544	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00865	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	10982827	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00548	RKIP	ARATH|TAIR=AT5G03840|UniProtKB=P93003	Protein TERMINAL FLOWER 1	ISS			PTHR11362:SF13	PROTEIN TERMINAL FLOWER 1
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	CAEEL|WormBase=WBGene00002232|UniProtKB=O17798	Furin-like protease kpc-1	IDA			PTHR42884:SF3	FURIN-LIKE PROTEASE 1, ISOFORMS 1/1-X/2
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05915	Opioid proenkephalin pathway	P05990	K+ channel	MOUSE|MGI=MGI=1100509|UniProtKB=O35111	Potassium channel subfamily K member 3	ISS	11875121	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	HUMAN|HGNC=7572|UniProtKB=Q9UKX2	Myosin-2	IEP	89264452	PubMed	PTHR13140:SF385	MYOSIN-2
P02788	Xanthine and guanine salvage pathway	P03247	Xanthine phosphoribosyl transferase	ARATH|TAIR=AT1G71750|UniProtKB=F4IA25	Hypoxanthine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01449	Nemo-like Kinase	RAT|RGD=1561602|UniProtKB=D3ZSZ3	Serine/threonine-protein kinase NLK	ISS	10683140	PubMed	PTHR24055:SF179	SERINE/THREONINE-PROTEIN KINASE NLK
P00057	Wnt signaling pathway	P01428	Frizzled	MACMU|Ensembl=ENSMMUG00000007486|UniProtKB=F6QL95	Frizzled-3	ISS	8717036	PubMed	PTHR11309:SF22	FRIZZLED-3
P00021	FGF signaling pathway	P00629	PP2A	MACMU|Ensembl=ENSMMUG00000020819|UniProtKB=F7HSM1	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00011	Blood coagulation	P00458	GP IIIa	BOVIN|Ensembl=ENSBTAG00000009987|UniProtKB=F1MTN1	Integrin beta	ISS	484963	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00019	Endothelin signaling pathway	P00591	PLCbeta	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00029	Huntington disease	P00807	Actin	DANRE|ZFIN=ZDB-GENE-030131-55|UniProtKB=Q6XNL8	Actin	IDA	10974003	PubMed	PTHR11937:SF263	ACTIN
P00054	Toll receptor signaling pathway	P01368	MKK2	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00036	Interleukin signaling pathway	P00980	IRS1/2	HUMAN|HGNC=6125|UniProtKB=P35568	Insulin receptor substrate 1	IGI	1311924	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P02741	Flavin biosynthesis	P02935	GTP cyclohydrolase	CHLTR|EnsemblGenome=CT_731|UniProtKB=O84736	Riboflavin biosynthesis protein RibBA	ISS			PTHR21327:SF32	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00590	IP3 R	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00018	EGF receptor signaling pathway	P00543	ERK1-2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01215	Syntaxin	PANTR|Ensembl=ENSPTRG00000018607|UniProtKB=H2QTR3	Syntaxin 7	ISS	10321247	PubMed	PTHR19957:SF90	SYNTAXIN-7
P00010	B cell activation	P00383	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	MYCTU|EnsemblGenome=Rv3436c|UniProtKB=P9WN49	Glutamine--fructose-6-phosphate aminotransferase [isomerizing]	ISS			PTHR10937:SF0	GH12731P-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	HUMAN|HGNC=6091|UniProtKB=P06213	Insulin receptor	ISS	2983222	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000016758|UniProtKB=H2QQP7	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF290	CADHERIN-10
P00036	Interleukin signaling pathway	P00977	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00019	Endothelin signaling pathway	P00572	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P02729	Ascorbate degradation	P02849	L-xylulose kinase	HUMAN|HGNC=12839|UniProtKB=O75191	Xylulose kinase	ISS			PTHR10196:SF57	XYLULOSE KINASE
P02756	N-acetylglucosamine metabolism	P03041	Glucosamine-6-phosphate deaminase	FUSNN|EnsemblGenome=FN1143|UniProtKB=Q8REG1	Glucosamine-6-phosphate deaminase	ISS			PTHR11280:SF5	GLUCOSAMINE-6-PHOSPHATE ISOMERASE
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	MACMU|Ensembl=ENSMMUG00000016428|UniProtKB=F7GU00	Metabotropic glutamate receptor 1 isoform alpha	ISS	7476890	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00562	p38	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	IGI	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01153	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00029	Huntington disease	P00779	TBP	PYRAE|EnsemblGenome=PAE2164|UniProtKB=Q8ZVR0	TATA-box-binding protein	IPI	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00059	p53 pathway	G04694	p110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00009	Axon guidance mediated by netrin	P00359	NFAT	MOUSE|MGI=MGI=1920431|UniProtKB=Q8K120	Nuclear factor of activated T-cells, cytoplasmic 4	IDA	12015605	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00037	Ionotropic glutamate receptor pathway	P01015	Glu4	PANTR|Ensembl=ENSPTRG00000004233|UniProtKB=H2Q4N9	Uncharacterized protein	ISS	12497607	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	BOVIN|Gene=MYH2|UniProtKB=Q9BE41	Myosin-2	ISS	10938134	PubMed	PTHR13140:SF385	MYOSIN-2
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	RAT|RGD=2738|UniProtKB=Q00960	Glutamate receptor ionotropic, NMDA 2B	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00006	Apoptosis signaling pathway	P00321	HSP70	MACMU|Ensembl=ENSMMUG00000004696|UniProtKB=F6RLH5	Heat shock cognate 71 kDa protein isoform 1	ISS	12150907	PubMed	PTHR19375:SF239	HEAT SHOCK COGNATE 71 KDA PROTEIN
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00034	Integrin signalling pathway	P00912	Arp2/3	PANTR|Ensembl=ENSPTRG00000021362|UniProtKB=H2QXW1	Actin-related protein 2/3 complex subunit 5	ISS	12473693	PubMed	PTHR12644:SF2	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5-LIKE PROTEIN
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MACMU|Ensembl=ENSMMUG00000010266|UniProtKB=F6PV18	Uncharacterized protein	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	CHICK|Ensembl=ENSGALG00000017238|UniProtKB=F1NWG3	Uncharacterized protein	ISS	8314195	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	HUMAN|HGNC=4593|UniProtKB=Q13255	Metabotropic glutamate receptor 1	ISS	7476890	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000002339|UniProtKB=H2R368	Uncharacterized protein	ISS	20088160	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P02725	Allantoin degradation	P02821	Allantoate amidohydrolase	DANRE|ZFIN=ZDB-GENE-040718-471|UniProtKB=Q6DGA6	Allantoicase	ISS			PTHR12045:SF3	ALLANTOICASE-RELATED
P00029	Huntington disease	P00774	Dynein complex	CHICK|Ensembl=ENSGALG00000009722|UniProtKB=E1C7N2	Uncharacterized protein	ISS	9454836	PubMed	PTHR12442:SF34	CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN 1
P04393	Ras Pathway	P04558	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	HUMAN|HGNC=704|UniProtKB=O15143	Actin-related protein 2/3 complex subunit 1B	ISS	12932731	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	CANLF|Ensembl=ENSCAFG00000019633|UniProtKB=F1PDC7	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	RCA	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00054	Toll receptor signaling pathway	P01375	JNK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	ISS	12040174	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	IC	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00036	Interleukin signaling pathway	P00996	STAT	MOUSE|MGI=MGI=103038|UniProtKB=P42227	Signal transducer and activator of transcription 3	IC	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MOUSE|MGI=MGI=95819|UniProtKB=P35438	Glutamate receptor ionotropic, NMDA 1	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ARATH|TAIR=AT3G15120|UniProtKB=F4IXH3	P-loop containing nucleoside triphosphate hydrolases superfamily protein	ISS			PTHR23069:SF3	P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05915	Opioid proenkephalin pathway	P05992	met-Enkephalin	XENTR|Xenbase=XB-GENE-942760|UniProtKB=F6Y5F6	Uncharacterized protein	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00029	Huntington disease	P00805	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00048	PI3 kinase pathway	P01177	P110ACT	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	ANOGA|Gene=AgaP_AGAP011382|UniProtKB=Q7Q2X0	AGAP011382-PA (Fragment)	TAS	8717036	PubMed	PTHR11309:SF47	FRIZZLED
P00021	FGF signaling pathway	P00648	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DROME|FlyBase=FBgn0014011|UniProtKB=P48554	Ras-related protein Rac2	ISS	4757952	gi	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	IDA	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00029	Huntington disease	P00807	Actin	DROME|FlyBase=FBgn0000044|UniProtKB=P53501	Actin-57B	IDA	10974003	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04393	Ras Pathway	P04555	PDK	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	IDA	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00005	Angiogenesis	P00236	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	ARATH|TAIR=AT1G13890|UniProtKB=Q9LMG8	Putative SNAP25 homologous protein SNAP30	IC			PTHR19305:SF7	SNAP25 HOMOLOGOUS PROTEIN SNAP30-RELATED
P00018	EGF receptor signaling pathway	P00546	GAP	DROME|FlyBase=FBgn0015269|UniProtKB=Q9VBJ2	Neurofibromin 1, isoform B	ISS	7511973	gi	PTHR10194:SF60	NEUROFIBROMIN
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00550	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8617307	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00005	Angiogenesis	P00243	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	TAS	12086862	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01423	p38MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	RAT|RGD=2738|UniProtKB=Q00960	Glutamate receptor ionotropic, NMDA 2B	IC	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00054	Toll receptor signaling pathway	P01358	ERK1	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00021	FGF signaling pathway	P00644	p38	CAEEL|WormBase=WBGene00004055|UniProtKB=Q17446	Mitogen-activated protein kinase pmk-1	IGI	11707292	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00049	Parkinson disease	P01229	Pael-R	MOUSE|MGI=MGI=1928503|UniProtKB=Q99JG2	Prosaposin receptor GPR37L1	ISS			PTHR24243:SF33	PROSAPOSIN RECEPTOR GPR37L1
P04375	5HT3 type receptor mediated signaling pathway	P04422	5HT3 Rec	PANTR|Ensembl=ENSPTRG00000004301|UniProtKB=H2Q4T1	Uncharacterized protein	ISS	7509203	PubMed	PTHR18945:SF52	5-HYDROXYTRYPTAMINE RECEPTOR 3A
P02738	De novo purine biosynthesis	P02908	Phosphoribosylamine glycine ligase	METJA|EnsemblGenome=MJ_0937|UniProtKB=Q58347	Phosphoribosylamine--glycine ligase	ISS			PTHR43472:SF1	PHOSPHORIBOSYLAMINE--GLYCINE LIGASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PRIPA|Gene=PPA17339|UniProtKB=H3F5B4	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF352	ACTIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	SCHPO|PomBase=SPAC22F8.11|UniProtKB=P40977	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00036	Interleukin signaling pathway	P00968	Ikk	PANTR|Ensembl=ENSPTRG00000020202|UniProtKB=H2QW34	Uncharacterized protein	ISS	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P04393	Ras Pathway	P04552	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00644	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	ISS	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00021	FGF signaling pathway	P00624	14-3-3	CAEBR|Gene=CBG17289|UniProtKB=A8XQR9	14-3-3 zeta	ISS	97315111	PubMed	PTHR18860:SF13	14-3-3 PROTEIN ZETA
P00019	Endothelin signaling pathway	P00572	MEK	CAEEL|WormBase=WBGene00003186|UniProtKB=Q10664	Dual specificity mitogen-activated protein kinase kinase mek-2	IGI	12024031	PubMed	PTHR24361:SF629	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1
P00046	Oxidative stress response	P01121	MKK3/6	MACMU|Ensembl=ENSMMUG00000010904|UniProtKB=F7GLY5	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IGI	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01443	Phospholipase C	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00001	Adrenaline and noradrenaline biosynthesis	P00066	DOPA decarb.	MACMU|Ensembl=ENSMMUG00000019991|UniProtKB=F7FNW0	Aromatic-L-amino-acid decarboxylase	ISS	7567987	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00014	Cholesterol biosynthesis	P00494	Squalene monooxygenas	ARATH|TAIR=AT5G24150|UniProtKB=O65404	Squalene epoxidase 5	ISS			PTHR10835:SF1	SQUALENE EPOXIDASE 4-RELATED
P02763	Peptidoglycan biosynthesis	P03090	N-Acetylglucosaminyl transferase	AQUAE|EnsemblGenome=aq_1177|UniProtKB=O67238	UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase	ISS			PTHR21015:SF22	GLYCOSYLTRANSFERASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00539	14-3-3	CANLF|Ensembl=ENSCAFG00000013549|UniProtKB=E2QVP6	Uncharacterized protein	ISS	1317796	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00034	Integrin signalling pathway	P00912	Arp2/3	DANRE|ZFIN=ZDB-GENE-040116-1|UniProtKB=Q7ZUQ0	Actin related protein 2/3 complex, subunit 1A	ISS	12473693	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00053	T cell activation	P01315	Calcineurin	RAT|RGD=3382|UniProtKB=P63329	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	IGI	7532676	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00938	Cdc42	TAKRU|Ensembl=ENSTRUG00000013411|UniProtKB=H2UB84	Uncharacterized protein	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00005	Angiogenesis	P00211	GSK3beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DROME|FlyBase=FBgn0001105|UniProtKB=P26308	Guanine nucleotide-binding protein subunit beta-1	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00544	c-Cbl	HUMAN|HGNC=1541|UniProtKB=P22681	E3 ubiquitin-protein ligase CBL	IGI	4885117	gi	PTHR23007:SF5	E3 UBIQUITIN-PROTEIN LIGASE CBL
P00012	Cadherin signaling pathway	P00475	Frizzled	PANTR|Ensembl=ENSPTRG00000028511|UniProtKB=H2R570	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF81	FRIZZLED-1
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IGI	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	HUMAN|HGNC=10484|UniProtKB=Q92736	Ryanodine receptor 2	ISS	15226293	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00005	Angiogenesis	P00203	Erk	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	TAS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00034	Integrin signalling pathway	P00949	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	7680960	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	BOVIN|Ensembl=ENSBTAG00000007909|UniProtKB=F1MPE9	Uncharacterized protein	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P05913	Enkephalin release	P05974	G-Protein (i)	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	ASHGO|EnsemblGenome=AGOS_ACR225C|UniProtKB=Q75BP6	ACR225Cp	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00047	PDGF signaling pathway	P01159	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00036	Interleukin signaling pathway	P00990	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02750	Lipoate_biosynthesis	P03004	Lipoate synthase	BACSU|EnsemblGenome=BSU32330|UniProtKB=O32129	Lipoyl synthase	ISS			PTHR10949:SF24	LIPOYL SYNTHASE
P04393	Ras Pathway	P04558	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00034	Integrin signalling pathway	P00922	Collagen	HUMAN|HGNC=2211|UniProtKB=P12109	Collagen alpha-1(VI) chain	IDA	10778855	PubMed	PTHR44172:SF3	COLLAGEN ALPHA-1 VI  CHAIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	ARATH|TAIR=AT5G61210|UniProtKB=Q9S7P9	SNAP25 homologous protein SNAP33	IC			PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	RAT|RGD=69430|UniProtKB=P32851	Syntaxin-1A	IC	1321498	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00006	Apoptosis signaling pathway	P00321	HSP70	PRIPA|Gene=PPA05202|UniProtKB=H3E674	Hsp-1	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000035697|UniProtKB=Q28024	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P02738	De novo purine biosynthesis	P02894	IMP cyclohydrolase	HUMAN|HGNC=794|UniProtKB=P31939	Bifunctional purine biosynthesis protein PURH	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	PANTR|Ensembl=ENSPTRG00000017441|UniProtKB=H2QRU7	Glutamate receptor, ionotropic, AMPA 1	ISS	10331083	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	BOVIN|Ensembl=ENSBTAG00000021672|UniProtKB=F1MUR0	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF34	REGULATOR OF G-PROTEIN SIGNALING 1
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	MONDO|Ensembl=ENSMODG00000017515|UniProtKB=F7F0J5	Uncharacterized protein	ISS	600075	OMIM	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00054	Toll receptor signaling pathway	P01369	MKK1	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06739	MEK1/2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	RCA	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P06215	MYO signaling pathway	P06310	BABO	DROME|FlyBase=FBgn0011300|UniProtKB=A1Z7L8	Receptor protein serine/threonine kinase	IEA	10683140	PubMed	PTHR23255:SF71	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	DICDI|dictyBase=DDB_G0279605|UniProtKB=P34148	Rho-related protein racB	ISS			PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00034	Integrin signalling pathway	P00932	FAK	PANTR|Ensembl=ENSPTRG00000020104|UniProtKB=H2QVX8	PTK2B protein tyrosine kinase 2 beta	ISS	12640026	PubMed	PTHR24418:SF94	PROTEIN-TYROSINE KINASE 2-BETA
P05915	Opioid proenkephalin pathway	P05994	G-protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00023	General transcription regulation	P00660	RNA Polymerase II	XENTR|Xenbase=XB-GENE-1005304|UniProtKB=Q28HF5	Polymerase (RNA) II (DNA directed) polypeptide E	ISS			PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P00010	B cell activation	P00398	IP3R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00048	PI3 kinase pathway	P01199	Galpha	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00997	Shc	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	IC	8264585	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MONDO|Ensembl=ENSMODG00000012009|UniProtKB=F7AMI2	Uncharacterized protein	ISS	12441358	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00629	PP2A	ORYSJ|EnsemblGenome=OS09G0284200|UniProtKB=Q6EPR6	Serine/threonine-protein phosphatase	ISS			PTHR11668:SF22	SERINE/THREONINE-PROTEIN PHOSPHATASE 4 CATALYTIC SUBUNIT
P00012	Cadherin signaling pathway	P00470	F-actin	TAKRU|Ensembl=ENSTRUG00000004787|UniProtKB=P53480	Actin, alpha cardiac	IC	11889126	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00020	FAS signaling pathway	P00615	JNK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02774	Salvage pyrimidine deoxyribonucleotides	P03146	Deoxyuridine kinase	ARATH|TAIR=AT3G07800|UniProtKB=Q9S750	Thymidine kinase a	ISS			PTHR11441:SF0	THYMIDINE KINASE, CYTOSOLIC
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	PHYPA|Gene=PHYPADRAFT_175379|UniProtKB=A9RJ42	Predicted protein	ISS			PTHR23073:SF24	26S PROTEASE REGULATORY SUBUNIT 4
P00006	Apoptosis signaling pathway	P00274	JNK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00006	Apoptosis signaling pathway	P00321	HSP70	ANOGA|EnsemblGenome=AGAP004944|UniProtKB=Q7Q7Y8	AGAP004944-PA	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01444	Wnt	MACMU|Ensembl=ENSMMUG00000004904|UniProtKB=F7CJE4	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DANRE|ZFIN=ZDB-GENE-000329-1|UniProtKB=Q7ZVI7	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00005	Angiogenesis	P00211	GSK3beta	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00034	Integrin signalling pathway	P00928	alpha actinin	CANLF|Ensembl=ENSCAFG00000016534|UniProtKB=E2QY08	Uncharacterized protein	ISS	2116421	PubMed	PTHR43947:SF3	ALPHA-ACTININ-1
P00029	Huntington disease	P00807	Actin	PLAF7|EnsemblGenome=PF14_0124|UniProtKB=Q8ILW9	Actin-2	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00018	EGF receptor signaling pathway	P00558	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00049	Parkinson disease	P01236	Casein kinase II	CANLF|Ensembl=ENSCAFG00000006946|UniProtKB=E2RHZ1	Uncharacterized protein	ISS	10806215	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	PANTR|Ensembl=ENSPTRG00000019627|UniProtKB=H2QVA4	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MACMU|Ensembl=ENSMMUG00000011852|UniProtKB=F7H4T8	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00126	Fe65	MACMU|Ensembl=ENSMMUG00000001707|UniProtKB=F7FWD3	Amyloid beta A4 protein-binding family B member 3 isoform b	ISS			PTHR14058:SF10	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 3
P00057	Wnt signaling pathway	P01443	Phospholipase C	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000009626|UniProtKB=F6ZYQ0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00010	B cell activation	P00383	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00029	Huntington disease	P00801	Fos protein	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	TAS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02760	PRPP biosynthesis	P03064	Phosphopentose mutase	THEMA|EnsemblGenome=TM_0167|UniProtKB=Q9WY14	Phosphopentomutase	ISS			PTHR21110:SF0	PHOSPHOPENTOMUTASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	TAS	12464394	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IDA	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00059	p53 pathway	P01486	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	BOVIN|Ensembl=ENSBTAG00000018270|UniProtKB=F1MGR9	Uncharacterized protein	ISS	12787506	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P04398	p53 pathway feedback loops 2	P04651	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00053	T cell activation	P01330	IKK	RAT|RGD=1306661|UniProtKB=G3V926	Conserved helix-loop-helix ubiquitous kinase (Predicted)	ISS	14499113	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00566	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06959	CCKR signaling map	P07025	HBEGF	HUMAN|HGNC=3059|UniProtKB=Q99075	Proheparin-binding EGF-like growth factor	RCA	9395517	PubMed	PTHR10740:SF4	PROHEPARIN-BINDING EGF-LIKE GROWTH FACTOR
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	RCA	176892	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P02723	Adenine and hypoxanthine salvage pathway	P02804	Hypoxanthine phosphoribosyl transferase	BACTN|EnsemblGenome=BT_4386|UniProtKB=Q89ZJ1	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=1306541|UniProtKB=D3ZVF3	Phosphoinositide-3-kinase, class 2, beta polypeptide (Predicted)	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00009	Axon guidance mediated by netrin	P00359	NFAT	MOUSE|MGI=MGI=103296|UniProtKB=P97305	Nuclear factor of activated T-cells, cytoplasmic 3	IDA	12015605	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	CHICK|Ensembl=ENSGALG00000004693|UniProtKB=Q5ZJI7	Uncharacterized protein	ISS	12963527	gi	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00048	PI3 kinase pathway	P01199	Galpha	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04397	p53 pathway by glucose deprivation	P04641	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04552	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	IDA	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00053	T cell activation	P01312	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IC	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00034	Integrin signalling pathway	P00916	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00053	T cell activation	P01336	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IGI	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00005	Angiogenesis	P00223	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	PANTR|Gene=CXCR1|UniProtKB=P55920	C-X-C chemokine receptor type 1	ISS	1840701	PubMed	PTHR10489:SF916	C-X-C CHEMOKINE RECEPTOR TYPE 1
P00005	Angiogenesis	P00221	JNK1	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02762	Pentose phosphate pathway	P03080	Glucose-P-Isomerase	CANLF|Ensembl=ENSCAFG00000007303|UniProtKB=E2R2C3	Glucose-6-phosphate isomerase	ISS	2248981	PubMed	PTHR11469:SF4	GLUCOSE-6-PHOSPHATE ISOMERASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00020	FAS signaling pathway	P00615	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00013	Cell cycle	P00481	APC	HUMAN|HGNC=19989|UniProtKB=Q9UJX6	Anaphase-promoting complex subunit 2	IDA	7019327	gi	PTHR11932:SF5	ANAPHASE-PROMOTING COMPLEX SUBUNIT 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00852	PYK2	BOVIN|Ensembl=ENSBTAG00000005958|UniProtKB=F1N0Z0	Uncharacterized protein	ISS	10753828	PubMed	PTHR24418:SF94	PROTEIN-TYROSINE KINASE 2-BETA
P00006	Apoptosis signaling pathway	P00260	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00090	MDC9	RAT|RGD=621473|UniProtKB=E9PTA4	Protein Adam9	ISS	10510302	PubMed	PTHR11905:SF136	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 9
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02776	Serine glycine biosynthesis	P03160	Phosphoglycerate dehydrogenase	HALSA|EnsemblGenome=VNG_2424G|UniProtKB=Q9HMR0	D-3-phosphoglycerate dehydrogenase	ISS			PTHR42938:SF9	FORMATE DEHYDROGENASE 1-RELATED
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04398	p53 pathway feedback loops 2	G04711	SIAH-1	PANTR|Ensembl=ENSPTRG00000008094|UniProtKB=H2QB23	E3 ubiquitin-protein ligase	ISS	14985507	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00570	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MOUSE|MGI=MGI=1351342|UniProtKB=Q3UVX5	Metabotropic glutamate receptor 5	ISS	8314195	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00018	EGF receptor signaling pathway	P00564	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00048	PI3 kinase pathway	P01182	Ras	DANRE|ZFIN=ZDB-GENE-990415-166|UniProtKB=P79737	GTPase NRas	ISS	9116869	PubMed	PTHR24070:SF189	GTPASE NRAS
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	HUMAN|HGNC=9509|UniProtKB=P49810	Presenilin-2	IDA	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	RAT|RGD=735207|UniProtKB=P80202	Activin receptor type-1B	IDA			PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P00021	FGF signaling pathway	P00641	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06768	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	RCA	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04393	Ras Pathway	P04559	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00030	Hypoxia response via HIF activation	P00819	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	NEUCR|EnsemblGenome=EFNCRG00000004240|UniProtKB=Q01386	cAMP-dependent protein kinase regulatory subunit	IC	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00137	Tip60	PANTR|Ensembl=ENSPTRG00000003890|UniProtKB=H2Q441	Histone acetyltransferase	ISS	11441186	PubMed	PTHR10615:SF124	HISTONE ACETYLTRANSFERASE KAT5
P00029	Huntington disease	P00767	Pro-caspase 8	MOUSE|MGI=MGI=1261423|UniProtKB=O89110	Caspase-8	IDA	8681376	PubMed	PTHR10454:SF162	CASPASE-8
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04398	p53 pathway feedback loops 2	P04651	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P00055	Transcription regulation by bZIP transcription factor	P01386	TFIIEbeta	DROME|FlyBase=FBgn0015829|UniProtKB=O96881	Transcription initiation factor IIE subunit beta	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P00021	FGF signaling pathway	P00645	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	HUMAN|HGNC=707|UniProtKB=P59998	Actin-related protein 2/3 complex subunit 4	ISS	9230079	PubMed	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P04393	Ras Pathway	P04556	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	ANOGA|EnsemblGenome=AGAP002355|UniProtKB=Q7QBX9	Glutamine synthetase	ISS			PTHR20852:SF57	GLUTAMINE SYNTHETASE 2 CYTOPLASMIC
P02788	Xanthine and guanine salvage pathway	P03245	Guanine phosphoribosyl transferase	TRYB2|Gene=Tb10.70.6540|UniProtKB=Q38C93	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00059	p53 pathway	G04699	BAI-1	BOVIN|Ensembl=ENSBTAG00000015335|UniProtKB=G3N2A9	Uncharacterized protein	ISS			PTHR12011:SF40	ADHESION G PROTEIN-COUPLED RECEPTOR B3
P04393	Ras Pathway	P04542	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00056	VEGF signaling pathway	P01414	PLC-gamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05915	Opioid proenkephalin pathway	P05994	G-protein	DROME|FlyBase=FBgn0004623|UniProtKB=P29829	Guanine nucleotide-binding protein subunit beta-2	IC			PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00029	Huntington disease	P00805	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01147	Nck	MONDO|Ensembl=ENSMODG00000018540|UniProtKB=F7GD33	Uncharacterized protein	ISS	12874226	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02747	Histidine biosynthesis	P02986	Phosphoribosyl ATP pyrophosphatase	DEIRA|EnsemblGenome=DR_0733|UniProtKB=Q9RWD6	Histidine biosynthesis bifunctional protein HisIE	ISS			PTHR42945:SF1	HISTIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN HISIE, CHLOROPLASTIC
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	TAS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=97438|UniProtKB=P32300	Delta-type opioid receptor	IDA	11259487	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00057	Wnt signaling pathway	P01451	Galpha	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00034	Integrin signalling pathway	P00907	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	BOVIN|Ensembl=ENSBTAG00000004429|UniProtKB=F1MT44	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF44	GROWTH/DIFFERENTIATION FACTOR 5
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00053	T cell activation	P01312	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	ISS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00049	Parkinson disease	P01238	14-3-3	CHICK|Ensembl=ENSGALG00000016433|UniProtKB=Q5ZMD1	14-3-3 protein theta	ISS	10407019	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P02765	Phenylalanine biosynthesis	P03099	Prephenate dehydratase	ARATH|TAIR=AT2G27820|UniProtKB=Q9ZUY3	Arogenate dehydratase 3, chloroplastic	ISS			PTHR21022:SF14	AROGENATE DEHYDRATASE 3, CHLOROPLASTIC-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008422|UniProtKB=F6VUT7	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=2136745|UniProtKB=Q91VE5	Protein Pcdhb10	IDA	8120095	PubMed	PTHR24028:SF90	PROTOCADHERIN BETA-5
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	G04694	p110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	ORNAN|Ensembl=ENSOANG00000004058|UniProtKB=F6TYP9	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00052	TGF-beta signaling pathway	P01275	P38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	TAS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00010	B cell activation	P00381	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00009	Axon guidance mediated by netrin	P00363	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	8649368	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00047	PDGF signaling pathway	P01142	p90RSK	BOVIN|Ensembl=ENSBTAG00000017639|UniProtKB=F1MZW8	Ribosomal protein S6 kinase	ISS	10480933	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00035	Interferon-gamma signaling pathway	P00954	Interferongamma	MACMU|Ensembl=ENSMMUG00000019225|UniProtKB=P63310	Interferon gamma	TAS	11929133	PubMed	PTHR11419:SF0	INTERFERON GAMMA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	ISS	8838325	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000001583|UniProtKB=F7BBM1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MONDO|Ensembl=ENSMODG00000001775|UniProtKB=F6WJB1	Uncharacterized protein	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	PANTR|Ensembl=ENSPTRG00000019361|UniProtKB=H2QUV3	Uncharacterized protein	ISS	20012997	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01414	PLC-gamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00047	PDGF signaling pathway	P01154	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00005	Angiogenesis	P00219	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04395	Vasopressin synthesis	P04596	Endo Peptidase	TRYB2|Gene=Tb11.52.0003|UniProtKB=Q382P7	Oligopeptidase b	IC			PTHR11757:SF3	PROTEASE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04586	ProTRH (Pro Thyrotropin-releasing Hormone)	XENTR|Xenbase=XB-GENE-478483|UniProtKB=F6W2E6	Glycoprotein hormones alpha chain	ISS			PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P05915	Opioid proenkephalin pathway	P05994	G-protein	RAT|RGD=69319|UniProtKB=P54313	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00029	Huntington disease	P00778	NMDA receptor	DROME|FlyBase=FBgn0010399|UniProtKB=Q24418	Glutamate [NMDA] receptor subunit 1	IDA	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01062	mGluR1	RAT|RGD=2742|UniProtKB=P23385	Metabotropic glutamate receptor 1	ISS	9407094	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00006	Apoptosis signaling pathway	P00302	ATF	HUMAN|HGNC=792|UniProtKB=P17544	Cyclic AMP-dependent transcription factor ATF-7	ISS	11390664	PubMed	PTHR19304:SF10	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-7
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=4404|UniProtKB=P59768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P02748	Isoleucine biosynthesis	P02994	Branched chain amino acid aminotransferase	CAEEL|WormBase=WBGene00012855|UniProtKB=Q9XXD8	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF28	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	PANTR|Ensembl=ENSPTRG00000006553|UniProtKB=A5A6H0	C-fos	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00030	Hypoxia response via HIF activation	P00819	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	TAS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00470	F-actin	MOUSE|MGI=MGI=87904|UniProtKB=P60710	Actin, cytoplasmic 1	IC	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00060	Ubiquitin proteasome pathway	P01491	E2	BOVIN|Gene=UBE2E3|UniProtKB=Q2T9X7	Ubiquitin-conjugating enzyme E2 E3	ISS			PTHR24068:SF63	UBIQUITIN-CONJUGATING ENZYME E2 E3
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	RAT|RGD=621705|UniProtKB=Q8VHN2	Glutamate receptor ionotropic, NMDA 3B	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00047	PDGF signaling pathway	P01159	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04567	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Ensembl=ENSPTRG00000013825|UniProtKB=H2RAK4	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	CAEEL|WormBase=WBGene00000055|UniProtKB=P48180	Acetylcholine receptor subunit alpha-type acr-16	ISS	85270494	PubMed	PTHR18945:SF578	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-TYPE ACR-16
P05913	Enkephalin release	P05977	G-Protein (s)	DICPU|Gene=DICPUDRAFT_93216|UniProtKB=F1A421	Guanine nucleotide-binding protein subunit beta	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P06959	CCKR signaling map	P07025	HBEGF	HUMAN|HGNC=3059|UniProtKB=Q99075	Proheparin-binding EGF-like growth factor	RCA	14764442	PubMed	PTHR10740:SF4	PROHEPARIN-BINDING EGF-LIKE GROWTH FACTOR
P00017	DNA replication	P00527	Histones	BOVIN|Ensembl=ENSBTAG00000024175|UniProtKB=P68432	Histone H3.1	ISS	12413958	PubMed	PTHR11426:SF167	HISTONE H3.1
P00047	PDGF signaling pathway	P01153	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00056	VEGF signaling pathway	P01403	VEGFR-2	BOVIN|Ensembl=ENSBTAG00000000782|UniProtKB=F1MWF1	Uncharacterized protein	ISS	11824379	PubMed	PTHR24416:SF45	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	ISS	11319238	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00010	B cell activation	P00381	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	CAEEL|WormBase=WBGene00004287|UniProtKB=Q94124	Ras-related protein rac-2	ISS	22392988	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00023	General transcription regulation	P00658	TBP-associated factors	PANTR|Ensembl=ENSPTRG00000008411|UniProtKB=H2QBM1	Uncharacterized protein	ISS	20355009	PubMed	PTHR15319:SF1	TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT C
P00009	Axon guidance mediated by netrin	P00366	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00048	PI3 kinase pathway	P01177	P110ACT	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00052	TGF-beta signaling pathway	P01275	P38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00036	Interleukin signaling pathway	P00976	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00047	PDGF signaling pathway	P01174	Rho	DROME|FlyBase=FBgn0030685|UniProtKB=X2JDY8	GRAF ortholog, isoform G	ISS			PTHR12552:SF1	GRAF ORTHOLOG, ISOFORM G
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	DROME|FlyBase=FBgn0001123|UniProtKB=P20354	G protein alpha s subunit	ISS	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00010	B cell activation	P00398	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IGI	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00036	Interleukin signaling pathway	P00970	Interleukin	PANTR|Ensembl=ENSPTRG00000016418|UniProtKB=H2QQ44	Uncharacterized protein	ISS			PTHR45426:SF1	INTERLEUKIN-2
P00021	FGF signaling pathway	P00629	PP2A	RAT|RGD=3380|UniProtKB=P63331	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00034	Integrin signalling pathway	P00917	ELMO	MOUSE|MGI=MGI=2153045|UniProtKB=Q8BHL5	Engulfment and cell motility protein 2	IDA	12879077	PubMed	PTHR12771:SF8	ENGULFMENT AND CELL MOTILITY PROTEIN 2
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-1712|UniProtKB=Q6PBY0	Guanine nucleotide binding protein (G protein), beta 5	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00005	Angiogenesis	P00187	beta catenin	CANLF|Ensembl=ENSCAFG00000005204|UniProtKB=B6V8E6	Catenin beta-1	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P06664	Gonadotropin-releasing hormone receptor pathway	G06673	CGA	MOUSE|MGI=MGI=88390|UniProtKB=P01216	Glycoprotein hormones alpha chain	RCA	1099091	PubMed	PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MACMU|Ensembl=ENSMMUG00000017374|UniProtKB=F7H6T7	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P06213	DPP signaling pathway	P06291	DAD	DROME|FlyBase=FBgn0020493|UniProtKB=Q5U110	Mothers against decapentaplegic homolog	IEA	http://flybase.org/reports/FBgn0020493.html	Website	PTHR13703:SF44	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG
P05913	Enkephalin release	G06045	preproenkephalin	MACMU|Ensembl=ENSMMUG00000006775|UniProtKB=F7H3N8	Uncharacterized protein	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00539	14-3-3	TAKRU|Ensembl=ENSTRUG00000004697|UniProtKB=H2SFG7	Uncharacterized protein	ISS	9507245	gi	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P02736	Coenzyme A biosynthesis	P02882	Pantothenate cysteine ligase	AQUAE|EnsemblGenome=aq_815|UniProtKB=O66997	Pantothenate metabolism flavoprotein	ISS			PTHR14359:SF6	PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE
P00054	Toll receptor signaling pathway	P01381	Ubc13	BOVIN|Ensembl=ENSBTAG00000021767|UniProtKB=Q0P5K3	Ubiquitin-conjugating enzyme E2 N	ISS			PTHR43902:SF2	UBIQUITIN-CONJUGATING ENZYME E2 N
P00005	Angiogenesis	P00193	SOS-1	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	CHICK|Gene=GLUL|UniProtKB=P16580	Glutamine synthetase	ISS			PTHR20852:SF45	GLUTAMINE SYNTHETASE
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MOUSE|MGI=MGI=104589|UniProtKB=P63268	Actin, gamma-enteric smooth muscle	IDA	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	CHICK|Ensembl=ENSGALG00000008512|UniProtKB=F1P0S6	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00020	FAS signaling pathway	P00596	Caspase6	XENTR|Xenbase=XB-GENE-482797|UniProtKB=F6R1R1	Uncharacterized protein	ISS	10770929	PubMed	PTHR10454:SF164	CASPASE-6
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00005	Angiogenesis	P00185	JAK1	BOVIN|Ensembl=ENSBTAG00000003147|UniProtKB=F1N0D6	Tyrosine-protein kinase	ISS	9637709	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00010	B cell activation	P00383	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IDA	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00034	Integrin signalling pathway	P00933	Crk	RAT|RGD=1308531|UniProtKB=Q5U2U2	Crk-like protein	ISS	8649368	PubMed	PTHR19969:SF9	CRK-LIKE PROTEIN
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	MOUSE|MGI=MGI=99578|UniProtKB=Q61616	D(1A) dopamine receptor	ISS	11248120	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00045	Notch signaling pathway	P01109	Aph-1	MONDO|Ensembl=ENSMODG00000018778|UniProtKB=F7ADK5	Uncharacterized protein	ISS	12110170	PubMed	PTHR12889:SF3	GAMMA-SECRETASE SUBUNIT APH-1A
P04398	p53 pathway feedback loops 2	P04651	Ras	DANRE|ZFIN=ZDB-GENE-990415-166|UniProtKB=P79737	GTPase NRas	IDA	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02763	Peptidoglycan biosynthesis	P03083	UDP-N-acetylmuramoylalanine-D-glutamate ligase	LEPIN|EnsemblGenome=LA_0838|UniProtKB=Q8F7V4	UDP-N-acetylmuramoylalanine--D-glutamate ligase	ISS			PTHR43692:SF1	UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00034	Integrin signalling pathway	P00912	Arp2/3	CANLF|Ensembl=ENSCAFG00000015081|UniProtKB=E2RMT4	Uncharacterized protein	ISS	12963527	gi	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00049	Parkinson disease	P01219	SAPK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00048	PI3 kinase pathway	P01202	p85	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04541	p90RSK	RAT|RGD=1563860|UniProtKB=D3Z8E0	Ribosomal protein S6 kinase	ISS	10558991	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	HUMAN|HGNC=145|UniProtKB=P63267	Actin, gamma-enteric smooth muscle	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00047	PDGF signaling pathway	P01172	c-Myc	CANLF|Gene=MYC|UniProtKB=Q28350	Myc proto-oncogene protein	ISS	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04375	5HT3 type receptor mediated signaling pathway	P04425	K+ channel	RAT|RGD=621451|UniProtKB=Q9ES08	Potassium channel subfamily K member 9	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00012	Cadherin signaling pathway	P00471	Cadherin	CANLF|Ensembl=ENSCAFG00000006532|UniProtKB=F6Y4F1	Uncharacterized protein	ISS	8120095	PubMed	PTHR43956:SF6	PROTOCADHERIN-16
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P04393	Ras Pathway	P04567	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01286	TGFbeta	HUMAN|HGNC=4218|UniProtKB=Q9NR23	Growth/differentiation factor 3	TAS	9759503	PubMed	PTHR11848:SF38	GROWTH/DIFFERENTIATION FACTOR 3
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	CANLF|Ensembl=ENSCAFG00000015807|UniProtKB=E2R557	S-adenosylmethionine synthase	ISS			PTHR11964:SF11	S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-1
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CAEEL|WormBase=WBGene00000056|UniProtKB=Q6F6K3	AcetylCholine Receptor	IC			PTHR18945:SF453	ACETYLCHOLINE RECEPTOR
P00046	Oxidative stress response	P01131	MKP5	PANTR|Ensembl=ENSPTRG00000009056|UniProtKB=H2QCS1	Dual specificity phosphatase 14	ISS			PTHR10159:SF338	DUAL SPECIFICITY PROTEIN PHOSPHATASE 14
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	TAS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05730	Endogenous cannabinoid signaling	P05746	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IC	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	DICPU|Gene=DICPUDRAFT_85721|UniProtKB=F0Z6V2	Actin-related protein 2/3 complex subunit 4	ISS	5031595	gi	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00057	Wnt signaling pathway	P01455	Smad4	CHICK|Ensembl=ENSGALG00000006309|UniProtKB=Q56I99	Mothers against decapentaplegic homolog 5	ISS	12736218	PubMed	PTHR13703:SF36	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5
P00049	Parkinson disease	P01230	Src kinase	XENTR|Xenbase=XB-GENE-6053489|UniProtKB=F6S8L5	Tyrosine-protein kinase	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00017	DNA replication	P00527	Histones	IXOSC|EnsemblGenome=ISCW003178|UniProtKB=B7PAJ2	Histone H3	ISS	12413958	PubMed	PTHR11426:SF169	HISTONE H3
P04398	p53 pathway feedback loops 2	P04665	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	MACMU|Ensembl=ENSMMUG00000009885|UniProtKB=F6YL51	Uncharacterized protein	ISS	11907044	PubMed	PTHR44025:SF7	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B
P04393	Ras Pathway	P04559	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00035	Interferon-gamma signaling pathway	P00961	STAT1	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	14755057	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	CANLF|Gene=PSEN1|UniProtKB=Q6RH31	Presenilin-1	ISS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00018	EGF receptor signaling pathway	P00560	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	HUMAN|HGNC=239|UniProtKB=P40145	Adenylate cyclase type 8	IGI	2491850	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00046	Oxidative stress response	P01132	c-jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04393	Ras Pathway	P04543	MEKK1/4	PANTR|Ensembl=ENSPTRG00000016891|UniProtKB=H2R5K3	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	MACMU|Ensembl=ENSMMUG00000012657|UniProtKB=F7E7J1	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	SCHPO|PomBase=SPCC16C4.18c|UniProtKB=O74462	Transcription initiation factor TFIID subunit 6	ISS			PTHR10221:SF9	TAF6-LIKE RNA POLYMERASE II P300/CBP-ASSOCIATED FACTOR-ASSOCIATED FACTOR 65 KDA SUBUNIT 6L
P00037	Ionotropic glutamate receptor pathway	P01023	CaMKII	PANTR|Ensembl=ENSPTRG00000002643|UniProtKB=H2Q244	Uncharacterized protein	ISS	12888804	PubMed	PTHR43940:SF7	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT GAMMA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	CANLF|Ensembl=ENSCAFG00000028654|UniProtKB=J9P702	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P02756	N-acetylglucosamine metabolism	P03040	N-acetylneuraminate lyase	CANLF|Ensembl=ENSCAFG00000013160|UniProtKB=E2RAE9	Uncharacterized protein	ISS			PTHR12128:SF21	N-ACETYLNEURAMINATE LYASE
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	PANTR|Ensembl=ENSPTRG00000019739|UniProtKB=H2QVG0	Uncharacterized protein	ISS	123810	OMIM	PTHR22952:SF96	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04393	Ras Pathway	P04556	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DROME|FlyBase=FBgn0011743|UniProtKB=P45891	Actin-like protein 53D	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00029	Huntington disease	P00776	c-Jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00036	Interleukin signaling pathway	P00975	RasGAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	227170	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	HUMAN|HGNC=6698|UniProtKB=O75581	Low-density lipoprotein receptor-related protein 6	IDA	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00018	EGF receptor signaling pathway	P00562	p38	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	IGI	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00897	SHIP2	RAT|RGD=68396|UniProtKB=Q9WVR3	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	TAS	10610720	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P02769	Purine metabolism	P03115	Nucleoside Phosphorylase	PSEAE|EnsemblGenome=PA3004|UniProtKB=Q9HZK1	S-methyl-5'-thioinosine phosphorylase	ISS	10984043	PubMed	PTHR42679:SF2	S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE
P00011	Blood coagulation	P00414	Thrombin	PANTR|Ensembl=ENSPTRG00000003552|UniProtKB=H2Q3I2	Prothrombin	ISS	+176930	OMIM	PTHR24254:SF10	PROTHROMBIN
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	BOVIN|Ensembl=ENSBTAG00000030674|UniProtKB=Q0VCP1	Adenylate kinase 4, mitochondrial	ISS			PTHR23359:SF58	ADENYLATE KINASE 4, MITOCHONDRIAL
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	ORYSJ|EnsemblGenome=OS05G0413200|UniProtKB=Q76FS3	Tubulin beta-6 chain	ISS	9454836	PubMed	PTHR11588:SF249	SUBFAMILY NOT NAMED
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00056	VEGF signaling pathway	P01401	HIF-1	BOVIN|Gene=HIF1A|UniProtKB=Q9XTA5	Hypoxia-inducible factor 1-alpha	ISS	9606183	PubMed	PTHR23043:SF7	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04393	Ras Pathway	P04546	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	IDA	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	METJA|EnsemblGenome=MJ_1420|UniProtKB=Q58815	Glutamine--fructose-6-phosphate aminotransferase [isomerizing]	ISS			PTHR10937:SF0	GH12731P-RELATED
P00046	Oxidative stress response	P01129	JNK1/2	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05918	p38 MAPK pathway	P06020	p38delta	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	RCA	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00047	PDGF signaling pathway	P01159	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01170	PDGF	CHICK|Ensembl=ENSGALG00000012178|UniProtKB=F1NE37	Uncharacterized protein	ISS			PTHR11633:SF2	PLATELET-DERIVED GROWTH FACTOR SUBUNIT B
P00005	Angiogenesis	P00205	GAP	ORNAN|Ensembl=ENSOANG00000014753|UniProtKB=F7EPN2	Uncharacterized protein (Fragment)	ISS	15489039	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00141	Membrane metalloprotease	MOUSE|MGI=MGI=1346076|UniProtKB=Q9R0S3	Matrix metalloproteinase-17	RCA			PTHR10201:SF21	MATRIX METALLOPROTEINASE-17
P00021	FGF signaling pathway	P00629	PP2A	MOUSE|MGI=MGI=1321159|UniProtKB=P63330	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05918	p38 MAPK pathway	P06021	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12176041	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	HUMAN|HGNC=4583|UniProtKB=Q16478	Glutamate receptor ionotropic, kainate 5	ISS	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00015	Circadian clock system	G01501	cry	MOUSE|MGI=MGI=1270859|UniProtKB=Q9R194	Cryptochrome-2	IEP	14507900	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00036	Interleukin signaling pathway	P00974	Receptor subunit beta	HUMAN|HGNC=5972|UniProtKB=Q99665	Interleukin-12 receptor subunit beta-2	IDA	8943050	PubMed	PTHR23036:SF79	INTERLEUKIN-12 RECEPTOR SUBUNIT BETA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	DANRE|ZFIN=ZDB-GENE-040426-2487|UniProtKB=Q803G3	Serine/threonine-protein phosphatase	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	RAT|RGD=70497|UniProtKB=Q05982	Nucleoside diphosphate kinase A	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	HUMAN|HGNC=4572|UniProtKB=P42262	Glutamate receptor 2	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	TAS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00057	Wnt signaling pathway	P01448	CBP	ARATH|TAIR=AT1G67220|UniProtKB=Q9FYH1	Histone acetyltransferase HAC2	IDA	10769018	PubMed	PTHR13808:SF6	HISTONE ACETYLTRANSFERASE HAC2
P05913	Enkephalin release	P05977	G-Protein (s)	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00034	Integrin signalling pathway	P00924	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01411	Ras	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	ISS	12104050	PubMed	PTHR24070:SF189	GTPASE NRAS
P00019	Endothelin signaling pathway	P00585	ECE1-3	CANLF|Ensembl=ENSCAFG00000014920|UniProtKB=F1PK66	Uncharacterized protein	ISS	96192242	PubMed	PTHR11733:SF130	ENDOTHELIN-CONVERTING ENZYME 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000013316|UniProtKB=H2QK23	Uncharacterized protein	ISS	12562507	PubMed	PTHR24229:SF52	SOMATOSTATIN RECEPTOR TYPE 4
P06664	Gonadotropin-releasing hormone receptor pathway	P06834	MAP3Ks	MOUSE|MGI=MGI=1346875|UniProtKB=O08648	Mitogen-activated protein kinase kinase kinase 4	RCA	602425	OMIM	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00049	Parkinson disease	P01212	p38 MAPK	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	NAS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CHICK|Ensembl=ENSGALG00000009405|UniProtKB=F1NKF1	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01185	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00925	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	MOUSE|MGI=MGI=99685|UniProtKB=E9Q401	Ryanodine receptor 2	ISS	8930069	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00048	PI3 kinase pathway	P01199	Galpha	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	IC	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00019	Endothelin signaling pathway	P00591	PLCbeta	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	IGI	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P02770	Pyridoxal phosphate salvage pathway	P03122	Pyridoxamine kinase	BOVIN|Ensembl=ENSBTAG00000018186|UniProtKB=Q0II59	Pyridoxal kinase	ISS	10395444	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	XENTR|Xenbase=XB-GENE-6035431|UniProtKB=F6RJ06	Uncharacterized protein	ISS			PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00009	Axon guidance mediated by netrin	P00366	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	10891487	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	ANOGA|EnsemblGenome=AGAP011152|UniProtKB=Q7QHE3	Phosphoinositide phospholipase C	ISS			PTHR10336:SF91	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P06959	CCKR signaling map	P07026	Carboxypeptidase E	HUMAN|HGNC=2303|UniProtKB=P16870	Carboxypeptidase E	RCA	12479974	PubMed	PTHR11532:SF59	CARBOXYPEPTIDASE E
P00018	EGF receptor signaling pathway	P00558	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=69350|UniProtKB=D3ZE55	Protocadherin-8	ISS	8120095	PubMed	PTHR24028:SF46	PROTOCADHERIN-8
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	IDA	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00010	B cell activation	P00391	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000006495|UniProtKB=P11017	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	RAT|RGD=2520|UniProtKB=P61169	D(2) dopamine receptor	ISS	11861492	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00059	p53 pathway	P04630	PP2A	XENTR|Xenbase=XB-GENE-484003|UniProtKB=Q6P365	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IGI	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00049	Parkinson disease	P01228	DAT	HUMAN|HGNC=11049|UniProtKB=Q01959	Sodium-dependent dopamine transporter	ISS	15135042	PubMed	PTHR11616:SF38	SODIUM-DEPENDENT DOPAMINE TRANSPORTER
P00010	B cell activation	P00381	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00056	VEGF signaling pathway	P01409	cPLA2	ORNAN|Ensembl=ENSOANG00000001027|UniProtKB=F6QDY0	Phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MACMU|Ensembl=ENSMMUG00000010184|UniProtKB=F6SR09	Uncharacterized protein	ISS	92317054	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02755	Methylmalonyl pathway	P03033	Propionyl-CoA carboxylase	MACMU|Ensembl=ENSMMUG00000003262|UniProtKB=F7DJ09	Propionyl-CoA carboxylase beta chain, mitochondrial isoform 1	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	TAKRU|Ensembl=ENSTRUG00000014763|UniProtKB=H2ULB2	Uncharacterized protein	ISS			PTHR13140:SF728	MYOSIN HEAVY CHAIN, SKELETAL MUSCLE, ADULT
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05912	Dopamine receptor mediated signaling pathway	P05961	DOPA decarb.	HUMAN|HGNC=2719|UniProtKB=P20711	Aromatic-L-amino-acid decarboxylase	ISS	7567987	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P02738	De novo purine biosynthesis	P02889	dGDP kinase	CANLF|Ensembl=ENSCAFG00000015856|UniProtKB=J9P3S5	Nucleoside diphosphate kinase	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=97440|UniProtKB=P35377	Nociceptin receptor	IDA	11259498	PubMed	PTHR24229:SF11	NOCICEPTIN RECEPTOR
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00049	Parkinson disease	P01236	Casein kinase II	NEUCR|EnsemblGenome=EFNCRG00000005497|UniProtKB=Q8TG12	Casein kinase II subunit beta-1	IDA	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DANRE|ZFIN=ZDB-GENE-070705-73|UniProtKB=B8A561	Uncharacterized protein	IEP	89264452	PubMed	PTHR13140:SF676	MYOSIN, HEAVY POLYPEPTIDE 2, FAST MUSCLE SPECIFIC
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Gene=PCDH11X|UniProtKB=Q71M42	Protocadherin-11 X-linked	ISS	8120095	PubMed	PTHR43912:SF1	PROTOCADHERIN-11 X-LINKED-RELATED
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MONDO|Ensembl=ENSMODG00000016595|UniProtKB=F6ZDB2	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05916	Opioid prodynorphin pathway	P06002	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IGI	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00036	Interleukin signaling pathway	P00990	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00005	Angiogenesis	P00238	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00059	p53 pathway	P04630	PP2A	XENTR|Xenbase=XB-GENE-957248|UniProtKB=Q6GLE6	Serine/threonine-protein phosphatase	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	IPI	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00021	FGF signaling pathway	P00629	PP2A	MONDO|Ensembl=ENSMODG00000019007|UniProtKB=F7C5Z9	Uncharacterized protein	ISS	12110603	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00036	Interleukin signaling pathway	P00983	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00048	PI3 kinase pathway	P01188	Gbetagamma	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ORYSJ|EnsemblGenome=OS02G0325100|UniProtKB=Q6Z875	Os02g0325100 protein	ISS			PTHR23073:SF8	26S PROTEASE REGULATORY SUBUNIT 6B
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00001	Adrenaline and noradrenaline biosynthesis	P00064	NET	MOUSE|MGI=MGI=1270850|UniProtKB=O55192	Sodium-dependent noradrenaline transporter	ISS	97248649	PubMed	PTHR11616:SF37	SODIUM-DEPENDENT NORADRENALINE TRANSPORTER
P00030	Hypoxia response via HIF activation	P00824	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	TAS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	TAS	129387	gi	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	DAPPU|EnsemblGenome=DAPPUDRAFT_231787|UniProtKB=E9HKA6	Serine/threonine-protein phosphatase	ISS	8392016	PubMed	PTHR11668:SF402	SERINE/THREONINE-PROTEIN PHOSPHATASE
P00054	Toll receptor signaling pathway	P01358	ERK1	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	HUMAN|HGNC=7577|UniProtKB=P12883	Myosin-7	ISS	10938134	PubMed	PTHR13140:SF344	MYOSIN-7
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00052	TGF-beta signaling pathway	G01548	I-SMAD	PANTR|Ensembl=ENSPTRG00000007198|UniProtKB=H2Q9N7	Mothers against decapentaplegic homolog	ISS	9335505	PubMed	PTHR13703:SF28	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 6
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	IC	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00057	Wnt signaling pathway	P01438	PP2A	MOUSE|MGI=MGI=2388479|UniProtKB=Q6PD03	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform	ISS	10092233	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	BOVIN|Ensembl=ENSBTAG00000025337|UniProtKB=F1MZX6	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF504	MYOSIN-13
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	RCA	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00048	PI3 kinase pathway	P01189	PTEN	TAKRU|Ensembl=ENSTRUG00000009851|UniProtKB=H2TJ90	Uncharacterized protein	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	8925912	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00035	Interferon-gamma signaling pathway	P00960	PTP	MACMU|Ensembl=ENSMMUG00000013253|UniProtKB=F6ZJD8	Tyrosine-protein phosphatase non-receptor type	ISS	8096088	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00005	Angiogenesis	P00240	FRS-2	MACMU|Ensembl=ENSMMUG00000012417|UniProtKB=F7DJK6	Fibroblast growth factor receptor substrate 3	ISS			PTHR21258:SF39	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	129387	gi	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P05916	Opioid prodynorphin pathway	P06002	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00053	T cell activation	P01300	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00398	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IGI	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	ISS	96320556	PubMed	PTHR10048:SF14	PI-3 KINASE
P05731	GABA-B receptor II signaling	P05752	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00060	Ubiquitin proteasome pathway	P01491	E2	ARATH|TAIR=AT1G50490|UniProtKB=Q8L7T3	Ubiquitin-conjugating enzyme E2 20	ISS			PTHR43898:SF9	UBIQUITIN-CONJUGATING ENZYME E2 C
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00049	Parkinson disease	P01219	SAPK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	NAS	10207617	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IC	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	DANRE|ZFIN=ZDB-GENE-980526-437|UniProtKB=Q07998	Brachyury protein homolog A	IEP	12356903	PubMed	PTHR11267:SF84	BRACHYURY PROTEIN HOMOLOG A
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	PANTR|Ensembl=ENSPTRG00000005197|UniProtKB=A5A6J7	Ras-related protein Rap-1b	ISS	8576107	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00047	PDGF signaling pathway	P01160	IP3 receptor	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	MOUSE|MGI=MGI=87917|UniProtKB=Q01341	Adenylate cyclase type 6	IC	2491850	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04393	Ras Pathway	P04546	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00010	B cell activation	P00384	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00017	DNA replication	P00536	DNA Topisomerase	ARATH|TAIR=AT5G55310|UniProtKB=Q9FJ79	DNA topoisomerase 1 beta	ISS			PTHR10290:SF3	DNA TOPOISOMERASE 1
P02744	Fructose galactose metabolism	P02960	Galactokinase	ECOLI|EcoGene=EG10363|UniProtKB=P0A6T3	Galactokinase	ISS	2198256	PubMed	PTHR10457:SF6	GALACTOKINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2055|UniProtKB=P43140	Alpha-1A adrenergic receptor	IDA			PTHR24248:SF16	ALPHA-1A ADRENERGIC RECEPTOR
P00018	EGF receptor signaling pathway	P00555	MKK4,7	MONDO|Ensembl=ENSMODG00000014960|UniProtKB=F7D0A6	Uncharacterized protein	ISS	15039780	PubMed	PTHR24361:SF387	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CRYNJ|EnsemblGenome=CNA04650|UniProtKB=Q5KP06	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00053	T cell activation	P01306	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IDA	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P05730	Endogenous cannabinoid signaling	P05746	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00641	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00009	Axon guidance mediated by netrin	P00364	cdc42	DANRE|ZFIN=ZDB-GENE-030131-8783|UniProtKB=Q52WY2	Ras-like protein Cdc42a	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P05731	GABA-B receptor II signaling	P05754	Ggamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	LEIMA|EnsemblGenome=LmjF.35.4010|UniProtKB=Q9GNR4	Protein kinase A catalytic subunit isoform 1	IC	10218114	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	HUMAN|HGNC=11534|UniProtKB=Q15572	TATA box-binding protein-associated factor RNA polymerase I subunit C	ISS	20355009	PubMed	PTHR15319:SF1	TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT C
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00003	Alzheimer disease-amyloid secretase pathway	P00093	Tip60	RAT|RGD=620845|UniProtKB=O35431	Amyloid beta A4 precursor protein-binding family A member 2	IC			PTHR12345:SF12	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 2
P05916	Opioid prodynorphin pathway	P06002	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00005	Angiogenesis	P00197	Grb14	MOUSE|MGI=MGI=1355324|UniProtKB=Q9JLM9	Growth factor receptor-bound protein 14	ISS			PTHR11243:SF22	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 14
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	MOUSE|MGI=MGI=108186|UniProtKB=Q9DBF1	Alpha-aminoadipic semialdehyde dehydrogenase	IC			PTHR43521:SF1	ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE
P00053	T cell activation	P01312	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00018	EGF receptor signaling pathway	P00539	14-3-3	MONDO|Ensembl=ENSMODG00000015951|UniProtKB=F7FRT9	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MACMU|Ensembl=ENSMMUG00000001661|UniProtKB=F7GR69	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00018	EGF receptor signaling pathway	P00557	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01457	GBeta	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04578	Rho	XENTR|Xenbase=XB-GENE-489222|UniProtKB=Q28GJ8	Ras homolog gene family, member A	ISS	10556059	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04393	Ras Pathway	P04552	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IDA	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00057	Wnt signaling pathway	P01440	Cadherin	ANOGA|EnsemblGenome=AGAP004850|UniProtKB=Q7PPU8	AGAP004850-PA	ISS	8120095	PubMed	PTHR24026:SF51	PROTOCADHERIN-LIKE WING POLARITY PROTEIN STAN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	MOUSE|MGI=MGI=104742|UniProtKB=P63250	G protein-activated inward rectifier potassium channel 1	IDA	12374786	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00018	EGF receptor signaling pathway	P00564	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00047	PDGF signaling pathway	P01151	PKB	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	DROME|FlyBase=FBgn0004611|UniProtKB=P25455	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II	ISS	15611108	PubMed	PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IDA	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00029	Huntington disease	P00807	Actin	TAKRU|Ensembl=ENSTRUG00000007989|UniProtKB=P68140	Actin, alpha skeletal muscle A	IDA	10974003	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	HUMAN|HGNC=15963|UniProtKB=Q15825	Neuronal acetylcholine receptor subunit alpha-6	ISS	85270494	PubMed	PTHR18945:SF82	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-6
P00029	Huntington disease	P00796	Kainate receptor	MACMU|Ensembl=ENSMMUG00000004886|UniProtKB=F7AGT9	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00018	EGF receptor signaling pathway	P00558	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00233	CSL	MONDO|Ensembl=ENSMODG00000000129|UniProtKB=F6YB95	Uncharacterized protein	ISS	9043084	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	12488551	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00037	Ionotropic glutamate receptor pathway	P01015	Glu4	CHICK|Ensembl=ENSGALG00000017178|UniProtKB=F1N982	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00007	Axon guidance mediated by semaphorins	P00340	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12912997	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01192	p110	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05731	GABA-B receptor II signaling	P05752	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	RCA	91072385	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01190	PDK1 ACT	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	15531926	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00006	Apoptosis signaling pathway	P00269	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04393	Ras Pathway	P04548	ATF2	PANTR|Ensembl=ENSPTRG00000012660|UniProtKB=H2QJ07	Activating transcription factor 2	ISS	10207617	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	MACMU|Ensembl=ENSMMUG00000022872|UniProtKB=F6WMJ4	Low-density lipoprotein receptor-related protein 3	ISS	11907044	PubMed	PTHR44062:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IDA	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04556	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02927	Dihydrooratate oxidase	ARATH|TAIR=AT5G23300|UniProtKB=P32746	Dihydroorotate dehydrogenase (quinone), mitochondrial	ISS			PTHR43517:SF1	DIHYDROOROTATE DEHYDROGENASE  QUINONE , MITOCHONDRIAL
P00046	Oxidative stress response	P01135	p38	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	TAS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00549	EGF	RAT|RGD=1589860|UniProtKB=A0A0G2JYC9	Protein Nrg4	RCA			PTHR11100:SF20	PRO-NEUREGULIN-2, MEMBRANE-BOUND ISOFORM-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00021	FGF signaling pathway	P00627	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	20216076	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P02729	Ascorbate degradation	P02849	L-xylulose kinase	MACMU|Ensembl=ENSMMUG00000004847|UniProtKB=F7AX05	Uncharacterized protein	ISS			PTHR10196:SF57	XYLULOSE KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00053	T cell activation	P01306	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00019	Endothelin signaling pathway	P00566	ERK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	NAS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00019	Endothelin signaling pathway	P00571	Pro ET1-4	BOVIN|Ensembl=ENSBTAG00000021434|UniProtKB=Q867A9	Endothelin-2	ISS			PTHR13874:SF9	ENDOTHELIN-2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONBE|Gene=37852|UniProtKB=A9V489	Predicted protein	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00038	JAK/STAT signaling pathway	P01027	STAT	MACMU|Ensembl=ENSMMUG00000010705|UniProtKB=F7G8V4	Signal transducer and activator of transcription	ISS	8584036	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02771	Pyrimidine Metabolism	P03124	Methylmalonate Semialdehyde Dehydrogenase	CANLF|Ensembl=ENSCAFG00000016901|UniProtKB=J9P2I9	Uncharacterized protein	ISS	1527093	PubMed	PTHR43866:SF3	METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE  ACYLATING , MITOCHONDRIAL
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	IC	10074940	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P05915	Opioid proenkephalin pathway	P05985	Mu or Delta receptor	PANTR|Ensembl=ENSPTRG00000000440|UniProtKB=H2PYH8	Uncharacterized protein	ISS	12093103	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00025	Hedgehog signaling pathway	P00683	Slimb	MONDO|Ensembl=ENSMODG00000011788|UniProtKB=F7CC58	Uncharacterized protein	ISS	10074433	PubMed	PTHR44038:SF2	F-BOX/WD REPEAT-CONTAINING PROTEIN 1A
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00047	PDGF signaling pathway	P01160	IP3 receptor	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00049	Parkinson disease	P01208	Hsp70	GIAIC|EnsemblGenome=GL50803_17121|UniProtKB=A8B431	Bip	IDA	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05730	Endogenous cannabinoid signaling	P05746	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00572	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00035	Interferon-gamma signaling pathway	P00953	Jak1	MOUSE|MGI=MGI=96628|UniProtKB=P52332	Tyrosine-protein kinase JAK1	ISS	9637709	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	BOVIN|Ensembl=ENSBTAG00000007964|UniProtKB=Q148J6	Actin-related protein 2/3 complex subunit 4	ISS	9230079	PubMed	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00007	Axon guidance mediated by semaphorins	P00334	PlexinA1	MOUSE|MGI=MGI=107685|UniProtKB=P70206	Plexin-A1	IDA	10725340	PubMed	PTHR22625:SF35	PLEXIN-A1
P00004	Alzheimer disease-presenilin pathway	P00145	CD44	RAT|RGD=2307|UniProtKB=P26051	CD44 antigen	IDA	12223485	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04393	Ras Pathway	P04541	p90RSK	XENTR|Xenbase=XB-GENE-479496|UniProtKB=F6S876	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00021	FGF signaling pathway	P00640	PI3K	ARATH|TAIR=AT1G60490|UniProtKB=P42339	Phosphatidylinositol 3-kinase VPS34	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	MACMU|Ensembl=ENSMMUG00000001387|UniProtKB=F7D0B4	Uncharacterized protein	ISS	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00048	PI3 kinase pathway	P01188	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MONDO|Ensembl=ENSMODG00000020977|UniProtKB=F6S5B1	Uncharacterized protein (Fragment)	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	MACMU|Ensembl=ENSMMUG00000017017|UniProtKB=F7FVL2	Tyrosine-protein kinase	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00006	Apoptosis signaling pathway	P00278	Bag	MOUSE|MGI=MGI=108047|UniProtKB=Q60739	BAG family molecular chaperone regulator 1	IDA	7834747	PubMed	PTHR12329:SF16	BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1
P00010	B cell activation	P00371	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	RCA	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00899	IRS 1-4	PANTR|Ensembl=ENSPTRG00000012989|UniProtKB=H2QJJ4	Insulin receptor substrate 1	ISS	1311924	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P02731	Biotin biosynthesis	P02856	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	PSEAE|EnsemblGenome=PA0420|UniProtKB=Q9I693	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	ISS			PTHR42684:SF3	ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	HUMAN|HGNC=6093|UniProtKB=P14616	Insulin receptor-related protein	TAS	10226785	PubMed	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	RAT|RGD=3425|UniProtKB=P97887	Presenilin-1	TAS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	12805548	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00019	Endothelin signaling pathway	P00586	Gq	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00029	Huntington disease	P00807	Actin	STRPU|EnsemblGenome=SPU_026078|UniProtKB=W4ZD41	Uncharacterized protein	IDA	11889126	PubMed	PTHR11937:SF277	SUBFAMILY NOT NAMED
P02728	Arginine biosynthesis	P02847	N-actetylornithine deacetylase	ECOLI|EcoGene=EG11286|UniProtKB=P23908	Acetylornithine deacetylase	ISS			PTHR43808:SF1	ACETYLORNITHINE DEACETYLASE
P00006	Apoptosis signaling pathway	P00269	MAPK	ORYSJ|EnsemblGenome=OS06G0699400|UniProtKB=Q5Z859	Mitogen-activated protein kinase 4	ISS	6491800	gi	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	DROME|FlyBase=FBgn0004611|UniProtKB=P25455	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II	ISS	7822322	PubMed	PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	14526383	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00046	Oxidative stress response	P01135	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00057	Wnt signaling pathway	P01438	PP2A	PANTR|Ensembl=ENSPTRG00000006426|UniProtKB=H2Q8F8	Protein phosphatase 2, regulatory subunit B', epsilon isoform	ISS	8703017	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	MONDO|Ensembl=ENSMODG00000019259|UniProtKB=F6Q8Q1	Fructose-bisphosphate aldolase	ISS	7768978	PubMed	PTHR11627:SF3	FRUCTOSE-BISPHOSPHATE ALDOLASE C
P00036	Interleukin signaling pathway	P00970	Interleukin	BOVIN|Ensembl=ENSBTAG00000018200|UniProtKB=Q28028	Interleukin-15	IDA	9282828	PubMed	PTHR45114:SF1	INTERLEUKIN-15
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	LEIMA|EnsemblGenome=LmjF.35.3960|UniProtKB=E9AFM1	Protein kinase A catalytic subunit isoform 2	IC	10218114	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00807	Actin	XENTR|Xenbase=XB-GENE-480347|UniProtKB=Q6P640	Actin, alpha cardiac muscle 1	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	PANTR|Ensembl=ENSPTRG00000013628|UniProtKB=H2R4F5	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04393	Ras Pathway	P04558	p38	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	IDA	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00048	PI3 kinase pathway	P01199	Galpha	RAT|RGD=1309514|UniProtKB=D4AA42	Guanine nucleotide binding protein, alpha transducing 2 (Predicted), isoform CRA_b	ISS			PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01332	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P06959	CCKR signaling map	G07267	uPA	HUMAN|HGNC=9052|UniProtKB=P00749	Urokinase-type plasminogen activator	RCA	17575684	PubMed	PTHR24264:SF38	UROKINASE-TYPE PLASMINOGEN ACTIVATOR
P00034	Integrin signalling pathway	P00923	Arf1	DANRE|ZFIN=ZDB-GENE-010724-5|UniProtKB=Q803D1	ADP-ribosylation factor 1	ISS	12932731	PubMed	PTHR11711:SF294	ADP-RIBOSYLATION FACTOR 3
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000010591|UniProtKB=H2R6B7	Uncharacterized protein	ISS	11554554	PubMed	PTHR24356:SF246	SERINE/THREONINE-PROTEIN KINASE N1
P05913	Enkephalin release	P05974	G-Protein (i)	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05913	Enkephalin release	P05974	G-Protein (i)	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MACMU|Ensembl=ENSMMUG00000014762|UniProtKB=F7G0R4	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF344	MYOSIN-7
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	IC	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00021	FGF signaling pathway	P00648	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00006	Apoptosis signaling pathway	P00310	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00566	ERK	ORYSJ|EnsemblGenome=OS03G0285800|UniProtKB=Q10N20	Mitogen-activated protein kinase 5	ISS			PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ARATH|TAIR=AT5G59370|UniProtKB=P53494	Actin-4	IC	10974003	PubMed	PTHR11937:SF366	ACTIN-4
P00049	Parkinson disease	P01219	SAPK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00035	Interferon-gamma signaling pathway	P00956	SOCS	CHICK|Ensembl=ENSGALG00000010016|UniProtKB=B2WUP1	Suppressor of cytokine signaling 5	ISS	15032587	PubMed	PTHR44282:SF3	SUPPRESSOR OF CYTOKINE SIGNALING 5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	BOVIN|Ensembl=ENSBTAG00000047202|UniProtKB=G3N3K3	Uncharacterized protein	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	2837282	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00006	Apoptosis signaling pathway	P00302	ATF	RAT|RGD=2165|UniProtKB=P29596	Cyclic AMP-dependent transcription factor ATF-3	ISS	11390664	PubMed	PTHR23351:SF23	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-3
P00034	Integrin signalling pathway	P00912	Arp2/3	MACMU|Ensembl=ENSMMUG00000001458|UniProtKB=F7BKH1	Uncharacterized protein	ISS	12932731	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00036	Interleukin signaling pathway	P00973	PKB	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00796	Kainate receptor	HUMAN|HGNC=4583|UniProtKB=Q16478	Glutamate receptor ionotropic, kainate 5	IDA	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P02724	Alanine biosynthesis	P02815	Branched chain amino acid aminotransferase	CANLF|Ensembl=ENSCAFG00000011487|UniProtKB=F1PY28	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF51	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, CYTOSOLIC
P00006	Apoptosis signaling pathway	P00269	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9836512	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IDA	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00029	Huntington disease	P00799	JNK-2	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00048	PI3 kinase pathway	P01192	p110	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05915	Opioid proenkephalin pathway	P05994	G-protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8716|UniProtKB=Q9UN70	Protocadherin gamma-C3	IDA	8120095	PubMed	PTHR24028:SF70	PROTOCADHERIN GAMMA-C3
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01465	Ggamma	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00018	EGF receptor signaling pathway	P00558	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	PANTR|Ensembl=ENSPTRG00000014012|UniProtKB=H2QL57	Uncharacterized protein	ISS	10727440	PubMed	PTHR44172:SF3	COLLAGEN ALPHA-1 VI  CHAIN
P00057	Wnt signaling pathway	P01443	Phospholipase C	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IDA	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00006	Apoptosis signaling pathway	P00274	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05915	Opioid proenkephalin pathway	P05989	leu-Enkephalin	PANTR|Ensembl=ENSPTRG00000020270|UniProtKB=H2QW70	Proenkephalin	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00589	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00317	Fos	CANLF|Ensembl=ENSCAFG00000017040|UniProtKB=E2QYK5	Uncharacterized protein	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00045	Notch signaling pathway	P01110	Presenilin	HUMAN|HGNC=9508|UniProtKB=P49768	Presenilin-1	IDA	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00021	FGF signaling pathway	P00629	PP2A	MOUSE|MGI=MGI=1321161|UniProtKB=P62715	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00030	Hypoxia response via HIF activation	P00824	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	TAS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00004	Alzheimer disease-presenilin pathway	P00114	actin	SCHMA|EnsemblGenome=Smp_202970|UniProtKB=G4VLN1	Putative uncharacterized protein Smp_202970	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00627	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00029	Huntington disease	P00812	Caspase 3	MOUSE|MGI=MGI=107739|UniProtKB=P70677	Caspase-3	ISS	11675509	PubMed	PTHR10454:SF198	CASPASE-3
P00025	Hedgehog signaling pathway	P00682	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	MONDO|Ensembl=ENSMODG00000012761|UniProtKB=F6SJA3	Tyrosine-protein kinase receptor (Fragment)	ISS	6754360	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IDA	3755548	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00021	FGF signaling pathway	P00636	FGFR1-4	HUMAN|HGNC=3691|UniProtKB=P22455	Fibroblast growth factor receptor 4	IPI	93194827	PubMed	PTHR24416:SF343	FIBROBLAST GROWTH FACTOR RECEPTOR 4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04572	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05731	GABA-B receptor II signaling	P05754	Ggamma	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	IDA	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00053	T cell activation	P01323	I kappa B	BOVIN|Ensembl=ENSBTAG00000016683|UniProtKB=Q8WNW7	NF kappa B inhibitor alpha (Fragment)	ISS	14665694	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P02723	Adenine and hypoxanthine salvage pathway	P02811	Adenosine deaminase	HUMAN|HGNC=186|UniProtKB=P00813	Adenosine deaminase	ISS			PTHR11409:SF43	ADENOSINE DEAMINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	TAKRU|Ensembl=ENSTRUG00000014763|UniProtKB=H2ULB2	Uncharacterized protein	ISS			PTHR13140:SF728	MYOSIN HEAVY CHAIN, SKELETAL MUSCLE, ADULT
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00006	Apoptosis signaling pathway	P00321	HSP70	ARATH|TAIR=AT3G12580|UniProtKB=Q9LHA8	Probable mediator of RNA polymerase II transcription subunit 37c	ISS	12150907	PubMed	PTHR19375:SF255	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 37C-RELATED
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IC	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04674	Mdm2	BOVIN|Gene=MDM4|UniProtKB=Q2HJ21	Protein Mdm4	ISS			PTHR13844:SF20	PROTEIN MDM4
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	YEAST|SGD=S000000201|UniProtKB=P24583	Protein kinase C-like 1	TAS	90322419	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00018	EGF receptor signaling pathway	P00562	p38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IGI	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DROME|FlyBase=FBgn0261854|UniProtKB=A1Z9X0	Atypical protein kinase C	ISS	15572354	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00054	Toll receptor signaling pathway	P01367	MKK3	CANLF|Ensembl=ENSCAFG00000018530|UniProtKB=F1PXD3	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04393	Ras Pathway	P04567	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00048	PI3 kinase pathway	P01192	p110	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MACMU|Ensembl=ENSMMUG00000023684|UniProtKB=P69895	Tubulin beta chain	ISS	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00023	General transcription regulation	P00668	TFIIB	BATDJ|Gene=BATDEDRAFT_32931|UniProtKB=F4NX01	Putative uncharacterized protein	ISS			PTHR12458:SF8	CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	3035212	PubMed	PTHR24070:SF385	GTPASE HRAS
P00029	Huntington disease	P00773	Duo	RAT|RGD=621865|UniProtKB=P97924	Kalirin	IPI	9285789	PubMed	PTHR22826:SF49	KALIRIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	IC	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00036	Interleukin signaling pathway	P00983	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05754	Ggamma	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00010	B cell activation	P00385	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12676940	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00018	EGF receptor signaling pathway	P00552	Ras	MONDO|Ensembl=ENSMODG00000025248|UniProtKB=F7F5X1	Uncharacterized protein	ISS	3023884	PubMed	PTHR24070:SF186	GTPASE KRAS
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000024633|UniProtKB=F1MBU9	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=620146|UniProtKB=O08874	Serine/threonine-protein kinase N2	ISS	11554554	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	HUMAN|HGNC=1388|UniProtKB=O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	IDA	11976940	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00705	Gsalpha	MONDO|Ensembl=ENSMODG00000021434|UniProtKB=F7CB49	Uncharacterized protein	ISS	6309844	PubMed	PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06773	gnai/o	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	RCA	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00029	Huntington disease	P00807	Actin	STRPU|Gene=CYIIIA|UniProtKB=P53474	Actin, cytoskeletal 3A	IDA	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CHICK|Gene=ACTA2|UniProtKB=P08023	Actin, aortic smooth muscle	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00049	Parkinson disease	P01227	20S proteasome	RAT|RGD=61841|UniProtKB=P18420	Proteasome subunit alpha type-1	ISS	12859888	PubMed	PTHR11599:SF12	PROTEASOME SUBUNIT ALPHA TYPE-RELATED
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	IC	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01015	Glu4	DANRE|ZFIN=ZDB-GENE-030131-8013|UniProtKB=F1QBT6	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00006	Apoptosis signaling pathway	P00317	Fos	CANLF|Ensembl=ENSCAFG00000017040|UniProtKB=E2QYK5	Uncharacterized protein	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00057	Wnt signaling pathway	P01465	Ggamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00010	B cell activation	P00370	NFkappaB	PANTR|Ensembl=ENSPTRG00000002888|UniProtKB=H2Q2H2	Uncharacterized protein	ISS	12574369	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00036	Interleukin signaling pathway	P00973	PKB	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02738	De novo purine biosynthesis	P02891	GDP kinase	ORYSJ|EnsemblGenome=OS10G0563700|UniProtKB=Q7XC37	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00047	PDGF signaling pathway	P01143	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	SCHMA|EnsemblGenome=Smp_059340|UniProtKB=C4QDC7	Guanine nucleotide-binding protein G(S) subunit alpha (Adenylate cyclase-stimulating G alpha protein),putative	IC	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00022	General transcription by RNA polymerase I	P00657	TBP	CANLF|Ensembl=ENSCAFG00000014931|UniProtKB=E2RCC0	Uncharacterized protein	ISS			PTHR15938:SF0	HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00020	FAS signaling pathway	P00594	Caspase8	PANTR|Ensembl=ENSPTRG00000012798|UniProtKB=H2R695	CASP8 and FADD-like apoptosis regulator	ISS	8681376	PubMed	PTHR10454:SF8	CASP8 AND FADD-LIKE APOPTOSIS REGULATOR
P02775	Salvage pyrimidine ribonucleotides	P03151	Uracil phosphoribosyl  transferase	PSEAE|EnsemblGenome=PA4646|UniProtKB=Q9HVE6	Uracil phosphoribosyltransferase	ISS			PTHR10285:SF46	URACIL PHOSPHORIBOSYLTRANSFERASE, CHLOROPLASTIC
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	88241036	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00036	Interleukin signaling pathway	P00980	IRS1/2	PANTR|Ensembl=ENSPTRG00000012989|UniProtKB=H2QJJ4	Insulin receptor substrate 1	ISS	15110093	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00029	Huntington disease	P00799	JNK-2	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04393	Ras Pathway	P04564	MAPKAP	MOUSE|MGI=MGI=2143163|UniProtKB=Q3UMW7	MAP kinase-activated protein kinase 3	ISS	11157753	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	RCA	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00046	Oxidative stress response	P01129	JNK1/2	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01150	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00023	General transcription regulation	P00660	RNA Polymerase II	CAEEL|WormBase=WBGene00019246|UniProtKB=Q9N5K2	DNA-directed RNA polymerases I, II, and III subunit RPABC1	ISS	11313498	gi	PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=7577|UniProtKB=P12883	Myosin-7	IC	10938134	PubMed	PTHR13140:SF344	MYOSIN-7
P00035	Interferon-gamma signaling pathway	P00960	PTP	MONDO|Ensembl=ENSMODG00000003120|UniProtKB=F6WVD2	Tyrosine-protein phosphatase non-receptor type	ISS	14534538	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00053	T cell activation	P01336	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IGI	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02726	Aminobutyrate degradation	P02825	4-aminobutyrate aminotransferase	ECOLI|EcoGene=EG13187|UniProtKB=P50457	4-aminobutyrate aminotransferase PuuE	ISS			PTHR43206:SF3	4-AMINOBUTYRATE AMINOTRANSFERASE PUUE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06827	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	RCA	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04397	p53 pathway by glucose deprivation	P04636	S6K	MACMU|Ensembl=ENSMMUG00000019305|UniProtKB=F6S3T8	Ribosomal protein S6 kinase	ISS	11861821	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000022548|UniProtKB=F6Y9J9	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000022886|UniProtKB=E1BE29	Uncharacterized protein	ISS	15226293	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	DANRE|ZFIN=ZDB-GENE-040426-877|UniProtKB=F1Q6Z7	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04633	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00398	IP3R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00007	Axon guidance mediated by semaphorins	P00340	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	14564011	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00047	PDGF signaling pathway	P01168	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00921	PINCH	DROME|FlyBase=FBgn0020249|UniProtKB=Q8INQ9	AT21926p	IPI			PTHR24210:SF0	AT21926P
P00004	Alzheimer disease-presenilin pathway	P00114	actin	RAT|RGD=2026|UniProtKB=P68035	Actin, alpha cardiac muscle 1	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00034	Integrin signalling pathway	P00951	Jnk	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00010	B cell activation	P00376	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01199	Galpha	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00009	Axon guidance mediated by netrin	P00363	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05962	DAT	HUMAN|HGNC=11049|UniProtKB=Q01959	Sodium-dependent dopamine transporter	ISS	92107910	PubMed	PTHR11616:SF38	SODIUM-DEPENDENT DOPAMINE TRANSPORTER
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	MACMU|Ensembl=ENSMMUG00000010678|UniProtKB=F7AXI7	Uncharacterized protein	ISS	6717565	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	BOVIN|Ensembl=ENSBTAG00000020485|UniProtKB=P17870	Beta-arrestin-1	ISS	4757780	gi	PTHR11792:SF22	BETA-ARRESTIN-1
P04396	Vitamin D metabolism and pathway	P04605	P450 reductase	ANOGA|EnsemblGenome=AGAP000500|UniProtKB=Q7QFI3	AGAP000500-PA	TAS	2513880	PubMed	PTHR19384:SF17	NADPH--CYTOCHROME P450 REDUCTASE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	BOVIN|Ensembl=ENSBTAG00000045782|UniProtKB=Q6PX77	Bone morphogenetic protein 15	TAS	9759503	PubMed	PTHR11848:SF22	BONE MORPHOGENETIC PROTEIN 15
P00036	Interleukin signaling pathway	P00965	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00968	Ikk	BOVIN|Ensembl=ENSBTAG00000007591|UniProtKB=Q95KV1	Inhibitor of nuclear factor kappa-B kinase subunit alpha	ISS	14499113	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00558	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IGI	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00021	FGF signaling pathway	P00624	14-3-3	SCHPO|PomBase=SPAC17A2.13c|UniProtKB=P42657	DNA damage checkpoint protein rad25	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00006	Apoptosis signaling pathway	P00260	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	IC	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00037	Ionotropic glutamate receptor pathway	P01026	KA	HUMAN|HGNC=4583|UniProtKB=Q16478	Glutamate receptor ionotropic, kainate 5	ISS	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00020	FAS signaling pathway	P00610	MKK4	HUMAN|HGNC=6844|UniProtKB=P45985	Dual specificity mitogen-activated protein kinase kinase 4	TAS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04393	Ras Pathway	P04544	Grb2	HUMAN|HGNC=4566|UniProtKB=P62993	Growth factor receptor-bound protein 2	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00056	VEGF signaling pathway	P01415	MAPKAPK2/3	PANTR|Ensembl=ENSPTRG00000001915|UniProtKB=H2Q104	Mitogen-activated protein kinase-activated protein kinase 2	ISS	10779545	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	12805548	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00852	PYK2	RAT|RGD=628758|UniProtKB=P70600	Protein-tyrosine kinase 2-beta	ISS	12640026	PubMed	PTHR24418:SF94	PROTEIN-TYROSINE KINASE 2-BETA
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00009	Axon guidance mediated by netrin	P00366	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	20010089	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	TAS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P02757	O-antigen biosynthesis	P03050	dTDP-4-dehydrorhamnose reductase	METAC|EnsemblGenome=MA_3778|UniProtKB=Q8TJK6	dTDP-4-dehydrorhamnose reductase	ISS			PTHR10491:SF4	METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA
P04393	Ras Pathway	P04559	Rac	DROME|FlyBase=FBgn0014011|UniProtKB=P48554	Ras-related protein Rac2	IDA	4757952	gi	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00005	Angiogenesis	P00206	Wnt	MACMU|Ensembl=ENSMMUG00000021725|UniProtKB=F7E738	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	ARATH|TAIR=AT3G12670|UniProtKB=Q9LTW8	CTP synthase	ISS			PTHR11550:SF11	CTP SYNTHASE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00018	EGF receptor signaling pathway	P00547	PP2A	MACMU|Ensembl=ENSMMUG00000020819|UniProtKB=F7HSM1	Serine/threonine-protein phosphatase	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CHICK|Ensembl=ENSGALG00000008898|UniProtKB=F1P2J9	Uncharacterized protein	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P05918	p38 MAPK pathway	P06029	p38beta	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	RCA	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00053	T cell activation	P01312	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	BOVIN|Ensembl=ENSBTAG00000004279|UniProtKB=P61585	Transforming protein RhoA	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P06959	CCKR signaling map	P07095	PKCalpha	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	RCA	9230117	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00570	PKA	LEIMA|EnsemblGenome=LmjF.18.1080|UniProtKB=Q27687	Protein kinase A catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	YEAST|SGD=S000004219|UniProtKB=P19073	Cell division control protein 42	ISS			PTHR24072:SF192	CDC42 HOMOLOG
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	TAKRU|Ensembl=ENSTRUG00000000584|UniProtKB=H2RMN2	Uncharacterized protein	IDA	11861492	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00057	Wnt signaling pathway	P01447	Dishevelled	HUMAN|HGNC=3084|UniProtKB=O14640	Segment polarity protein dishevelled homolog DVL-1	ISS	7906389	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00029	Huntington disease	P00805	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IDA	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00015	Circadian clock system	G01497	cry	DANRE|ZFIN=ZDB-GENE-010426-3|UniProtKB=F1R1X1	Uncharacterized protein	ISS			PTHR11455:SF27	CRY1A PROTEIN
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06587	Nicotine pharmacodynamics pathway	P06601	FLNA	CANLF|Ensembl=ENSCAFG00000019521|UniProtKB=F1PWW0	Uncharacterized protein	ISS	9722563	PubMed	PTHR43998:SF6	FILAMIN-A
P00029	Huntington disease	P00775	Rac	CHICK|Ensembl=ENSGALG00000004796|UniProtKB=Q90694	Cell division control protein 42 homolog	TAS			PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00005	Angiogenesis	P00187	beta catenin	HUMAN|HGNC=2514|UniProtKB=P35222	Catenin beta-1	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00018	EGF receptor signaling pathway	P00561	STAT	BOVIN|Gene=STAT5B|UniProtKB=Q9TUM3	Signal transducer and activator of transcription 5B	ISS	20119183	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00018	EGF receptor signaling pathway	P00562	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04398	p53 pathway feedback loops 2	P04649	Myc	MACMU|Ensembl=ENSMMUG00000014601|UniProtKB=B8XIA5	Myc proto-oncogene protein	ISS	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g242065|UniProtKB=A7S0V7	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	14744463	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00036	Interleukin signaling pathway	P00990	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00805	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00034	Integrin signalling pathway	P00924	Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	IPI	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DAPPU|EnsemblGenome=DAPPUDRAFT_206575|UniProtKB=E9FUX0	Guanine nucleotide binding protein, beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00012	Cadherin signaling pathway	P00464	Fyn	MONDO|Ensembl=ENSMODG00000017905|UniProtKB=F7FG65	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DROME|FlyBase=FBgn0000046|UniProtKB=P10981	Actin-87E	IC	10974003	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00019	Endothelin signaling pathway	P00570	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00235	c-Fos	CANLF|Ensembl=ENSCAFG00000017040|UniProtKB=E2QYK5	Uncharacterized protein	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00021	FGF signaling pathway	P00634	MEKK1-5	HUMAN|HGNC=6854|UniProtKB=Q9Y2U5	Mitogen-activated protein kinase kinase kinase 2	IGI	11730323	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	RAT|RGD=70497|UniProtKB=Q05982	Nucleoside diphosphate kinase A	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	PANTR|Ensembl=ENSPTRG00000001767|UniProtKB=G2HG81	Actin-related protein 2/3 complex subunit 5	ISS	12473693	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00034	Integrin signalling pathway	P00951	Jnk	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00011	Blood coagulation	P00408	Plasminogen	BOVIN|Gene=PLG|UniProtKB=P06868	Plasminogen	ISS	85203906	PubMed	PTHR24261:SF5	PLASMINOGEN
P00034	Integrin signalling pathway	P00925	MEK	BOVIN|Ensembl=ENSBTAG00000012103|UniProtKB=A5PJP8	MAP2K4 protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	XENTR|Xenbase=XB-GENE-491356|UniProtKB=Q28J24	Transcription initiation factor TFIID subunit 8	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00010	B cell activation	P00402	Jnk	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00018	EGF receptor signaling pathway	P00539	14-3-3	CHICK|Ensembl=ENSGALG00000006743|UniProtKB=Q5ZKJ2	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00059	p53 pathway	G04702	p53	BOVIN|Ensembl=ENSBTAG00000001069|UniProtKB=P67939	Cellular tumor antigen p53	TAS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00005	Angiogenesis	P00235	c-Fos	CANLF|Ensembl=ENSCAFG00000017040|UniProtKB=E2QYK5	Uncharacterized protein	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00053	T cell activation	P01307	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00029	Huntington disease	P00776	c-Jun	CHICK|Gene=JUN|UniProtKB=P18870	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	IDA	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	TAS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00017	DNA replication	P00527	Histones	STRPU|EnsemblGenome=SPU_011743|UniProtKB=W4Y7N6	Uncharacterized protein	ISS	12413958	PubMed	PTHR11426:SF20	HISTONE H3-LIKE CENTROMERIC PROTEIN A
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	RCA	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00642	MEK1-2	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00557	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00010	B cell activation	P00371	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04398	p53 pathway feedback loops 2	P04658	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00034	Integrin signalling pathway	P00906	Rap1	CANLF|Ensembl=ENSCAFG00000000415|UniProtKB=E2R2K4	Uncharacterized protein	ISS	10476970	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	94280860	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00034	Integrin signalling pathway	P00951	Jnk	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00012	Cadherin signaling pathway	P00466	EGFR	TAKRU|Ensembl=ENSTRUG00000010319|UniProtKB=H2TMR9	Uncharacterized protein (Fragment)	ISS	3170544	gi	PTHR24416:SF382	SUBFAMILY NOT NAMED
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00012	Cadherin signaling pathway	P00466	EGFR	DROME|FlyBase=FBgn0003731|UniProtKB=P04412	Epidermal growth factor receptor	ISS	6175066	gi	PTHR24416:SF95	EPIDERMAL GROWTH FACTOR RECEPTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=11330|UniProtKB=P30872	Somatostatin receptor type 1	IDA	12441358	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00029	Huntington disease	P00805	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00017	DNA replication	P00527	Histones	BOVIN|Ensembl=ENSBTAG00000017016|UniProtKB=A5PK61	Histone H3.3C	ISS	12413958	PubMed	PTHR11426:SF179	HISTONE H3.3
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00034	Integrin signalling pathway	P00934	VASP	HUMAN|HGNC=12652|UniProtKB=P50552	Vasodilator-stimulated phosphoprotein	IPI	8836115	PubMed	PTHR11202:SF12	VASODILATOR-STIMULATED PHOSPHOPROTEIN
P00034	Integrin signalling pathway	P00907	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04553	PAK	RAT|RGD=3250|UniProtKB=P35465	Serine/threonine-protein kinase PAK 1	IDA	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P02728	Arginine biosynthesis	P02841	argininosuccinate lyase	RAT|RGD=619974|UniProtKB=P20673	Argininosuccinate lyase	ISS			PTHR43814:SF1	ARGININOSUCCINATE LYASE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00944	Actin	DICDI|dictyBase=DDB_G0275023|UniProtKB=Q553U6	Putative actin-22	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02775	Salvage pyrimidine ribonucleotides	P03150	Uridine kinase	ARATH|TAIR=AT3G27190|UniProtKB=Q9LK34	Uridine kinase-like protein 2, chloroplastic	ISS			PTHR10285:SF70	URIDINE-CYTIDINE KINASE 2
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1203729|UniProtKB=Q61194	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	IPI	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00029	Huntington disease	P00800	PolyQ Htt	RAT|RGD=68337|UniProtKB=P51111	Huntingtin	TAS	9462744	PubMed	PTHR10170:SF10	HUNTINGTIN
P00059	p53 pathway	P04612	HDAC1	ORNAN|Ensembl=ENSOANG00000003631|UniProtKB=F7FJQ1	Histone deacetylase	ISS	10485845	PubMed	PTHR10625:SF171	HISTONE DEACETYLASE 2
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MONDO|Ensembl=ENSMODG00000006494|UniProtKB=F7EKN9	Uncharacterized protein	ISS	10839363	PubMed	PTHR19957:SF104	SYNTAXIN-6
P00010	B cell activation	P00375	Calmodulin	CANLF|Ensembl=ENSCAFG00000017516|UniProtKB=E2REK6	Uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF311	CALMODULIN
P05913	Enkephalin release	P05977	G-Protein (s)	BOVIN|Ensembl=ENSBTAG00000003043|UniProtKB=P63212	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	DANRE|ZFIN=ZDB-GENE-030131-7595|UniProtKB=Q6PBR4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=1561991|UniProtKB=A0A096MJW8	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF51	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-1
P00053	T cell activation	P01297	MEKK	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	RCA	12049732	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00005	Angiogenesis	P00237	FRP	MACMU|Ensembl=ENSMMUG00000007486|UniProtKB=F6QL95	Frizzled-3	ISS	12549854	PubMed	PTHR11309:SF22	FRIZZLED-3
P00036	Interleukin signaling pathway	P00968	Ikk	HUMAN|HGNC=5960|UniProtKB=O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	IDA	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MOUSE|MGI=MGI=88397|UniProtKB=Q9ERZ4	Muscarinic acetylcholine receptor M2	TAS	91373358	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00047	PDGF signaling pathway	P01150	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04552	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-040426-2427|UniProtKB=F1Q6C0	Uncharacterized protein (Fragment)	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00057	Wnt signaling pathway	P01443	Phospholipase C	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IDA	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00015	Circadian clock system	G01503	per	MACMU|Ensembl=ENSMMUG00000021798|UniProtKB=F7ESU2	Uncharacterized protein	ISS	12782655	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000002349|UniProtKB=P61267	Syntaxin-1B	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	CAEEL|WormBase=WBGene00002173|UniProtKB=Q9Y0A1	Inositol 1,4,5-trisphosphate receptor itr-1	IDA	9065779	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00021	FGF signaling pathway	P00638	PLCgamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IGI	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	CHICK|Ensembl=ENSGALG00000019060|UniProtKB=F1NZ61	Uncharacterized protein	TAS	12834808	PubMed	PTHR10201:SF115	MATRIX METALLOPROTEINASE-27
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	STRCO|Gene=CAC32309|UniProtKB=Q9AK79	tRNA-specific adenosine deaminase	ISS			PTHR11079:SF149	TRNA-SPECIFIC ADENOSINE DEAMINASE
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8660|UniProtKB=O95206	Protocadherin-8	IDA	8120095	PubMed	PTHR24028:SF46	PROTOCADHERIN-8
P00056	VEGF signaling pathway	P01409	cPLA2	RAT|RGD=67366|UniProtKB=P50393	Cytosolic phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00006	Apoptosis signaling pathway	P00302	ATF	MOUSE|MGI=MGI=1932093|UniProtKB=P97875	Jun dimerization protein 2	ISS			PTHR23351:SF10	JUN DIMERIZATION PROTEIN 2
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	MACMU|Ensembl=ENSMMUG00000000800|UniProtKB=F6R1X3	Uncharacterized protein	ISS			PTHR10943:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2
P00021	FGF signaling pathway	P00628	JNK1-3	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00029	Huntington disease	P00811	Arp2/3 complex	MONDO|Ensembl=ENSMODG00000001303|UniProtKB=F7BZM9	Uncharacterized protein (Fragment)	ISS	12963527	gi	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00010	B cell activation	P00383	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IDA	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00017	DNA replication	P00529	RFC	HUMAN|HGNC=9971|UniProtKB=P40938	Replication factor C subunit 3	RCA			PTHR11669:SF1	REPLICATION FACTOR C SUBUNIT 3
P00006	Apoptosis signaling pathway	P00274	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00029	Huntington disease	P00790	beta-Tubulin	XENTR|Xenbase=XB-GENE-482185|UniProtKB=Q6GLE7	Tubulin beta chain	ISS	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	ECOLI|EcoGene=EG13604|UniProtKB=P77495	Propionate--CoA ligase	ISS			PTHR43347:SF3	ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06760	MKK4/7	MOUSE|MGI=MGI=1346871|UniProtKB=Q8CE90	Dual specificity mitogen-activated protein kinase kinase 7	RCA	15039780	PubMed	PTHR24361:SF387	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7
P00056	VEGF signaling pathway	P01411	Ras	CHICK|Ensembl=ENSGALG00000006885|UniProtKB=P08642	GTPase HRas	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00048	PI3 kinase pathway	P01196	PDK1	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	IGI	12855688	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	HUMAN|HGNC=8568|UniProtKB=P09958	Furin	IDA	10956649	PubMed	PTHR42884:SF1	FURIN
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	XENTR|Xenbase=XB-GENE-490883|UniProtKB=Q6NVA9	Actin, cytoplasmic 1	ISS	11889139	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P06959	CCKR signaling map	P07236	G17 - Gly	HUMAN|HGNC=4164|UniProtKB=P01350	Gastrin	RCA	11181951	PubMed	PTHR19309:SF0	GASTRIN
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MONDO|Ensembl=ENSMODG00000015792|UniProtKB=Q2QL96	Protein Wnt-2	ISS	11266476	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DROME|FlyBase=FBgn0261854|UniProtKB=A1Z9X0	Atypical protein kinase C	ISS	3045562	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00034	Integrin signalling pathway	P00925	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	IDA	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00036	Interleukin signaling pathway	P00972	MNK1/2	HUMAN|HGNC=7110|UniProtKB=Q9BUB5	MAP kinase-interacting serine/threonine-protein kinase 1	IC	11575158	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00983	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	3449797	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00049	Parkinson disease	P01208	Hsp70	CAEEL|WormBase=WBGene00009691|UniProtKB=G5ECU5	Uncharacterized protein	IDA	12150907	PubMed	PTHR19375:SF256	HSP70 PROTEIN-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	HUMAN|HGNC=145|UniProtKB=P63267	Actin, gamma-enteric smooth muscle	IC	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00053	T cell activation	P01314	nck	RAT|RGD=1305965|UniProtKB=D4A3M8	Non-catalytic region of tyrosine kinase adaptor protein 2 (Predicted)	ISS	12874226	PubMed	PTHR44108:SF1	CYTOPLASMIC PROTEIN NCK2
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	HUMAN|HGNC=1389|UniProtKB=Q00975	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	8386525	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CAEBR|Gene=CBG04190|UniProtKB=A8WWD7	Protein CBR-MEK-2	ISS	176872	OMIM	PTHR24361:SF629	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00015	Circadian clock system	G01499	per	PANTR|Ensembl=ENSPTRG00000008726|UniProtKB=H2QC70	Uncharacterized protein	ISS	20570170	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P04398	p53 pathway feedback loops 2	G04714	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	IGI	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000005917|UniProtKB=F6QM53	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PLAF7|EnsemblGenome=PF14_0124|UniProtKB=Q8ILW9	Actin-2	IDA			PTHR11937:SF155	ACTIN-5C-RELATED
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04398	p53 pathway feedback loops 2	P04668	p53	CANLF|Gene=TP53|UniProtKB=Q29537	Cellular tumor antigen p53	TAS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00036	Interleukin signaling pathway	P00977	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	10693759	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01457	GBeta	NEUCR|EnsemblGenome=EFNCRG00000000159|UniProtKB=F5HH30	Guanine nucleotide-binding protein beta subunit	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	DROME|FlyBase=FBgn0001991|UniProtKB=Q24270	Voltage-dependent calcium channel type D subunit alpha-1	ISS	15737619	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01188	Gbetagamma	CRYNJ|EnsemblGenome=CND03830|UniProtKB=Q5KI86	Uncharacterized protein	IGI	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00048	PI3 kinase pathway	P01185	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P02773	S-adenosylmethionine biosynthesis	P03142	Cobalamin-dependent homocysteine transmethylase	MYCTU|EnsemblGenome=Rv2124c|UniProtKB=O33259	Methionine synthase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P00034	Integrin signalling pathway	P00907	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	9298898	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01151	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04452	proopiomelanocortin	MACMU|Ensembl=ENSMMUG00000016463|UniProtKB=F7GBI0	Uncharacterized protein	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00057	Wnt signaling pathway	P01435	SWI/SNF	METAC|EnsemblGenome=MA_0189|UniProtKB=Q8TU84	Helicase (SNF2 family)	IDA	11532957	PubMed	PTHR10799:SF810	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	TAS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00046	Oxidative stress response	P01135	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	TAS	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00019	Endothelin signaling pathway	P00590	IP3 R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00034	Integrin signalling pathway	P00913	Csk	BOVIN|Ensembl=ENSBTAG00000021424|UniProtKB=Q0VBZ0	Tyrosine-protein kinase CSK	ISS	11078745	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P02743	Formyltetrahydroformate biosynthesis	P02952	Methylene tetrahydrofolate dehydrogenase	DROME|FlyBase=FBgn0010222|UniProtKB=Q04448	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	ISS			PTHR10025:SF46	BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, MITOCHONDRIAL
P00038	JAK/STAT signaling pathway	P01033	PTP	RAT|RGD=3451|UniProtKB=P04157	Receptor-type tyrosine-protein phosphatase C	ISS	8940015	PubMed	PTHR19134:SF284	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	MACMU|Ensembl=ENSMMUG00000009889|UniProtKB=F6YKC3	Uncharacterized protein	ISS			PTHR15938:SF0	HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	TAS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00029	Huntington disease	P00774	Dynein complex	HUMAN|HGNC=2949|UniProtKB=Q8TD57	Dynein heavy chain 3, axonemal	IPI	9454836	PubMed	PTHR10676:SF242	DYNEIN HEAVY CHAIN 3, AXONEMAL
P00023	General transcription regulation	P00658	TBP-associated factors	BOVIN|Ensembl=ENSBTAG00000027980|UniProtKB=Q17QQ4	Transcription initiation factor TFIID subunit 9	ISS			PTHR12595:SF8	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 9
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	IC	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	IDA	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	MACMU|Ensembl=ENSMMUG00000010678|UniProtKB=F7AXI7	Uncharacterized protein	ISS	9756087	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00050	Plasminogen activating cascade	P01243	uPA	MOUSE|MGI=MGI=97611|UniProtKB=P06869	Urokinase-type plasminogen activator	IGI	6679377	gi	PTHR24264:SF38	UROKINASE-TYPE PLASMINOGEN ACTIVATOR
P00057	Wnt signaling pathway	P01430	p53	DANRE|ZFIN=ZDB-GENE-990415-270|UniProtKB=P79734	Cellular tumor antigen p53	IDA	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00049	Parkinson disease	P01208	Hsp70	TAKRU|Ensembl=ENSTRUG00000003346|UniProtKB=H2S609	Uncharacterized protein	ISS	10934466	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00053	T cell activation	P01307	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00021	FGF signaling pathway	P00634	MEKK1-5	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	ISS	12049732	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00036	Interleukin signaling pathway	P00986	eNOS	CANLF|Gene=NOS3|UniProtKB=Q9TUX8	Nitric oxide synthase, endothelial	ISS	93055452	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00036	Interleukin signaling pathway	P00965	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IC	97442349	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	PANTR|Ensembl=ENSPTRG00000021182|UniProtKB=H2QXK2	Receptor protein serine/threonine kinase	ISS			PTHR23255:SF61	TGF-BETA RECEPTOR TYPE-1
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04397	p53 pathway by glucose deprivation	P04639	AMPK	PANTR|Ensembl=ENSPTRG00000005520|UniProtKB=G2HGR1	5'-AMP-activated protein kinase subunit beta-1	ISS			PTHR10343:SF16	5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	HUMAN|HGNC=1736|UniProtKB=P60953	Cell division control protein 42 homolog	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEEL|WormBase=WBGene00018620|UniProtKB=O44588	Uncharacterized protein	IC	2837282	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CANLF|Ensembl=ENSCAFG00000005662|UniProtKB=E2R907	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01098	CHT1	HUMAN|HGNC=11055|UniProtKB=P48029	Sodium- and chloride-dependent creatine transporter 1	ISS			PTHR11616:SF96	SODIUM- AND CHLORIDE-DEPENDENT CREATINE TRANSPORTER 1
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00005	Angiogenesis	P00187	beta catenin	CHICK|Ensembl=ENSGALG00000011905|UniProtKB=F1NHT7	Uncharacterized protein	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MACMU|Ensembl=ENSMMUG00000019112|UniProtKB=F6T8S6	N-methyl D-aspartate receptor subtype 2B	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00054	Toll receptor signaling pathway	P01375	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	CAEBR|Gene=CBG10154|UniProtKB=A8XAI1	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00047	PDGF signaling pathway	P01164	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	RCA	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00018	EGF receptor signaling pathway	P00561	STAT	MACMU|Ensembl=ENSMMUG00000005617|UniProtKB=F6WDY6	Signal transducer and activator of transcription	ISS	94255416	PubMed	PTHR11801:SF19	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 4
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	CHICK|Ensembl=ENSGALG00000012444|UniProtKB=Q90669	Activin receptor type-2A	TAS	11252892	PubMed	PTHR23255:SF64	ACTIVIN RECEPTOR TYPE-2A
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	RCA	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000021434|UniProtKB=F7CB49	Uncharacterized protein	ISS	2106672	PubMed	PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	TAS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01159	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00049	Parkinson disease	P01208	Hsp70	CHLRE|EnsemblGenome=CHLREDRAFT_185673|UniProtKB=A8JEU4	Heat shock protein 70A	IDA	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	DICDI|dictyBase=DDB_G0283907|UniProtKB=P34099	cAMP-dependent protein kinase catalytic subunit	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00059	p53 pathway	G04702	p53	ORNAN|Ensembl=ENSOANG00000013795|UniProtKB=F7DUR2	Uncharacterized protein (Fragment)	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00007	Axon guidance mediated by semaphorins	P00341	Rho	BOVIN|Ensembl=ENSBTAG00000004279|UniProtKB=P61585	Transforming protein RhoA	ISS	12039949	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000002775|UniProtKB=H2RB55	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00045	Notch signaling pathway	P01113	Pen-2	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	12846562	PubMed	PTHR10202:SF13	PRESENILIN-2
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	HUMAN|HGNC=404|UniProtKB=P05091	Aldehyde dehydrogenase, mitochondrial	IC			PTHR11699:SF233	ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL
P00005	Angiogenesis	P00243	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01381	Ubc13	MACMU|Ensembl=ENSMMUG00000030126|UniProtKB=F7HH32	Uncharacterized protein	ISS			PTHR43902:SF2	UBIQUITIN-CONJUGATING ENZYME E2 N
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00021	FGF signaling pathway	P00631	Grb2	DROME|FlyBase=FBgn0004638|UniProtKB=Q08012	Protein enhancer of sevenless 2B	ISS	51702266	gi	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	MONDO|Ensembl=ENSMODG00000003244|UniProtKB=F6THF0	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00019	Endothelin signaling pathway	P00589	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00048	PI3 kinase pathway	P01181	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00012	Cadherin signaling pathway	P00470	F-actin	CANLF|Ensembl=ENSCAFG00000016020|UniProtKB=O18840	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	RCA	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	IDA	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PANTR|Ensembl=ENSPTRG00000009762|UniProtKB=H2QE24	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00025	Hedgehog signaling pathway	P00682	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00048	PI3 kinase pathway	P01192	p110	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00800	PolyQ Htt	CANLF|Ensembl=ENSCAFG00000014682|UniProtKB=F1P7Y7	Uncharacterized protein	ISS	8268927	PubMed	PTHR10170:SF10	HUNTINGTIN
P00018	EGF receptor signaling pathway	P00558	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00048	PI3 kinase pathway	P01188	Gbetagamma	NEUCR|EnsemblGenome=EFNCRG00000000159|UniProtKB=F5HH30	Guanine nucleotide-binding protein beta subunit	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P06959	CCKR signaling map	P07021	MAPK7	HUMAN|HGNC=6880|UniProtKB=Q13164	Mitogen-activated protein kinase 7	RCA	12239223	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00018	EGF receptor signaling pathway	P00539	14-3-3	PANTR|Ensembl=ENSPTRG00000008521|UniProtKB=G2HI54	14-3-3 protein epsilon	ISS	98119747	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00019	Endothelin signaling pathway	P00566	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	8837781	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00005	Angiogenesis	P00203	Erk	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01444	Wnt	CANLF|Ensembl=ENSCAFG00000031321|UniProtKB=J9NZJ2	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_56687|UniProtKB=C3YC50	Putative uncharacterized protein	IDA	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00114	actin	USTMA|Gene=UMAG_11232|UniProtKB=A0A0D1DMT3	Chromosome 22, whole genome shotgun sequence	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00047	PDGF signaling pathway	P01148	Grb2	CAEBR|Gene=CBG16856|UniProtKB=A8XPY6	Protein CBR-SEM-5	ISS	8307166	PubMed	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00021	FGF signaling pathway	P00629	PP2A	ORNAN|Ensembl=ENSOANG00000008136|UniProtKB=F7F3Q5	Serine/threonine-protein phosphatase	ISS			PTHR11668:SF22	SERINE/THREONINE-PROTEIN PHOSPHATASE 4 CATALYTIC SUBUNIT
P02770	Pyridoxal phosphate salvage pathway	P03121	Pyridoxal kinase	SCHPO|PomBase=SPAC6F6.11c|UniProtKB=O14242	Putative pyridoxal kinase C6F6.11c	ISS	11859360	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	TAS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05924	AT1-R	MOUSE|MGI=MGI=87965|UniProtKB=P29755	Type-1B angiotensin II receptor	RCA			PTHR24228:SF32	TYPE-1B ANGIOTENSIN II RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00828	Galphai	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	RCA			PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00047	PDGF signaling pathway	P01145	c-fos	RAT|RGD=620975|UniProtKB=Q63665	Upstream stimulatory factor 2	ISS			PTHR12565:SF11	UPSTREAM STIMULATORY FACTOR 2
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00017	DNA replication	P00527	Histones	CANAL|CGD=CAL0000180612|UniProtKB=Q59VN2	Histone H3.1/H3.2	ISS	12413958	PubMed	PTHR11426:SF169	HISTONE H3
P00010	B cell activation	P00373	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IGI	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	MONDO|Ensembl=ENSMODG00000005255|UniProtKB=F7G800	Uncharacterized protein	ISS	7559398	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00019	Endothelin signaling pathway	P00591	PLCbeta	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IGI	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00018	EGF receptor signaling pathway	P00564	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12676940	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00021	FGF signaling pathway	P00627	ERK1-2	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00010	B cell activation	P00381	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00005	Angiogenesis	P00245	Rac	MONDO|Ensembl=ENSMODG00000019894|UniProtKB=F6W5V4	Uncharacterized protein	ISS	14724572	PubMed	PTHR23176:SF28	RHO GTPASE-ACTIVATING PROTEIN 1
P02746	Heme biosynthesis	P02972	Ferrochelatase	CHICK|Gene=FECH|UniProtKB=O42479	Ferrochelatase, mitochondrial	ISS			PTHR11108:SF1	FERROCHELATASE, MITOCHONDRIAL
P04392	P53 pathway feedback loops 1	G04682	MDM-2	MACMU|Ensembl=ENSMMUG00000011236|UniProtKB=F6WXF0	Uncharacterized protein	ISS			PTHR13844:SF20	PROTEIN MDM4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000014674|UniProtKB=P41985	Muscarinic acetylcholine receptor M2	ISS	8100450	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00010	B cell activation	P00380	fos	MONDO|Ensembl=ENSMODG00000005927|UniProtKB=F6WX28	Uncharacterized protein	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04393	Ras Pathway	P04572	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02738	De novo purine biosynthesis	P02902	ADP reductase	MYCTU|EnsemblGenome=Rv3051c|UniProtKB=P9WH75	Ribonucleoside-diphosphate reductase subunit alpha	ISS			PTHR11573:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS			PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00054	Toll receptor signaling pathway	P01369	MKK1	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IDA	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=30035|UniProtKB=Q8WYR1	Phosphoinositide 3-kinase regulatory subunit 5	ISS	129387	gi	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CAEEL|WormBase=WBGene00004037|UniProtKB=Q9XWB7	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF9	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	TAS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00007	Axon guidance mediated by semaphorins	P00341	Rho	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	ISS	12169092	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BRAFL|Gene=BRAFLDRAFT_220697|UniProtKB=C3ZSF0	Putative uncharacterized protein	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00001	Adrenaline and noradrenaline biosynthesis	P00062	TH	MACMU|Ensembl=ENSMMUG00000003912|UniProtKB=F6ZV38	Uncharacterized protein	ISS	12814656	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000014574|UniProtKB=F7GRQ5	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF12	PROTOCADHERIN BETA-1
P00018	EGF receptor signaling pathway	P00552	Ras	DICPU|Gene=DICPUDRAFT_92731|UniProtKB=F0ZWE6	Putative uncharacterized protein rasG	ISS	89128893	PubMed	PTHR24070:SF282	RAS GTPASE-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P06959	CCKR signaling map	P07223	Signal-pre-pro CCK	HUMAN|HGNC=1569|UniProtKB=P06307	Cholecystokinin	RCA	11232009	PubMed	PTHR10786:SF0	CHOLECYSTOKININ
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00003	Alzheimer disease-amyloid secretase pathway	P00084	X11alpha	RAT|RGD=620845|UniProtKB=O35431	Amyloid beta A4 precursor protein-binding family A member 2	IDA	9614075	PubMed	PTHR12345:SF12	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01275	P38	BOVIN|Ensembl=ENSBTAG00000030182|UniProtKB=G3X793	Mitogen-activated protein kinase	ISS	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IDA	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00005	Angiogenesis	P00207	Crk	XENTR|Xenbase=XB-GENE-976114|UniProtKB=F6QIM7	Uncharacterized protein	ISS			PTHR19969:SF9	CRK-LIKE PROTEIN
P00019	Endothelin signaling pathway	P00568	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00036	Interleukin signaling pathway	P00973	PKB	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00060	Ubiquitin proteasome pathway	P01491	E2	YEAST|SGD=S000004624|UniProtKB=Q02159	Ubiquitin-conjugating enzyme E2 7	ISS			PTHR24067:SF154	UBIQUITIN-CONJUGATING ENZYME E2 G2
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	HUMAN|HGNC=4595|UniProtKB=Q14832	Metabotropic glutamate receptor 3	ISS	12488551	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	ARATH|TAIR=AT1G60490|UniProtKB=P42339	Phosphatidylinositol 3-kinase VPS34	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00057	Wnt signaling pathway	P01430	p53	RAT|RGD=3889|UniProtKB=P10361	Cellular tumor antigen p53	IDA	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00036	Interleukin signaling pathway	P00965	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00007	Axon guidance mediated by semaphorins	P00341	Rho	MONDO|Ensembl=ENSMODG00000012981|UniProtKB=F7CS91	Uncharacterized protein	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DROME|FlyBase=FBgn0011743|UniProtKB=P45891	Actin-like protein 53D	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05918	p38 MAPK pathway	P06020	p38delta	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	RCA	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00022	General transcription by RNA polymerase I	P00649	TAF-IC	CAEEL|WormBase=WBGene00006390|UniProtKB=Q7YTH5	TAF (TBP-associated transcription factor) family	ISS			PTHR12321:SF78	TAF  TBP-ASSOCIATED TRANSCRIPTION FACTOR  FAMILY
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IGI	14526383	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00006	Apoptosis signaling pathway	P00302	ATF	MONDO|Ensembl=ENSMODG00000015970|UniProtKB=F7FD05	Uncharacterized protein	ISS	11390664	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00053	T cell activation	P01294	NFAT	HUMAN|HGNC=7777|UniProtKB=Q12968	Nuclear factor of activated T-cells, cytoplasmic 3	IGI	12015605	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00020	FAS signaling pathway	P00617	FasL	RAT|RGD=3880|UniProtKB=P36940	Tumor necrosis factor ligand superfamily member 6	ISS	12787569	PubMed	PTHR11471:SF33	TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 6
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=105372|UniProtKB=P49660	Somatostatin receptor type 4	IDA	12181435	PubMed	PTHR24229:SF52	SOMATOSTATIN RECEPTOR TYPE 4
P04395	Vasopressin synthesis	P04596	Endo Peptidase	BOVIN|Ensembl=ENSBTAG00000017429|UniProtKB=F1MZK8	Uncharacterized protein	ISS			PTHR11757:SF12	PROLYL ENDOPEPTIDASE-LIKE
P06664	Gonadotropin-releasing hormone receptor pathway	P06779	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	RCA	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00633	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00005	Angiogenesis	P00244	MAPKAPK2/3	BOVIN|Ensembl=ENSBTAG00000038107|UniProtKB=F1MCX5	Uncharacterized protein	ISS	7923354	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00029	Huntington disease	P00807	Actin	XENTR|Xenbase=XB-GENE-491618|UniProtKB=Q6P378	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P02761	Pantothenate biosynthesis	P03067	3-methyl-2-oxobutanoate hydroxymethyltransferase	BACSU|EnsemblGenome=BSU22430|UniProtKB=P52996	3-methyl-2-oxobutanoate hydroxymethyltransferase	ISS			PTHR20881:SF0	3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	10218114	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MACMU|Ensembl=ENSMMUG00000011773|UniProtKB=F7HQF4	Uncharacterized protein	ISS			PTHR24247:SF31	5-HYDROXYTRYPTAMINE RECEPTOR 2B
P00005	Angiogenesis	P00216	Caspase 9	PANTR|Ensembl=ENSPTRG00000000200|UniProtKB=H2PY35	Caspase	ISS	9390557	PubMed	PTHR10454:SF157	CASPASE-9
P00018	EGF receptor signaling pathway	P00562	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	ARATH|TAIR=AT5G07880|UniProtKB=Q9SD96	SNAP25 homologous protein SNAP29	IC			PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	SCHPO|PomBase=SPAC6G9.11|UniProtKB=Q92356	Synaptobrevin homolog 1	IC			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	IGI	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00059	p53 pathway	P04626	GADD45	DANRE|ZFIN=ZDB-GENE-040426-1501|UniProtKB=F1R8Z0	Uncharacterized protein	ISS			PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P02759	Pyridoxal-5-phosphate biosynthesis	P03061	Pyridoxine-5-phosphate oxidase	MACMU|Ensembl=ENSMMUG00000003325|UniProtKB=F7EHD9	Pyridoxine-5'-phosphate oxidase	ISS	14697241	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00005	Angiogenesis	P00206	Wnt	CAEEL|WormBase=WBGene00000858|UniProtKB=P34889	Protein Wnt-2	ISS	8717036	PubMed	PTHR12027:SF77	PROTEIN WNT-5
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00021	FGF signaling pathway	P00629	PP2A	HUMAN|HGNC=9310|UniProtKB=Q15173	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform	IGI	10092233	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	CRYNJ|EnsemblGenome=CND03830|UniProtKB=Q5KI86	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00055	Transcription regulation by bZIP transcription factor	P01389	TTF2	MACMU|Ensembl=ENSMMUG00000022278|UniProtKB=F6XFN3	Uncharacterized protein	ISS	604718	OMIM	PTHR15437:SF1	TRANSCRIPTION TERMINATION FACTOR 2, MITOCHONDRIAL
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00010	B cell activation	P00379	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00717	Phosphorylase b	HUMAN|HGNC=9723|UniProtKB=P11216	Glycogen phosphorylase, brain form	IDA	4318782	PubMed	PTHR11468:SF1	GLYCOGEN PHOSPHORYLASE, BRAIN FORM
P00036	Interleukin signaling pathway	P00965	ERK	HUMAN|HGNC=24667|UniProtKB=Q8TD08	Mitogen-activated protein kinase 15	IC	12787066	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00011	Blood coagulation	P00458	GP IIIa	BOVIN|Ensembl=ENSBTAG00000009987|UniProtKB=F1MTN1	Integrin beta	ISS	5805339	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	PANTR|Ensembl=ENSPTRG00000018059|UniProtKB=C7G3M9	Glutamate receptor, metabotropic 4	ISS	12351712	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P04393	Ras Pathway	P04569	Cdc42	CHICK|Ensembl=ENSGALG00000004796|UniProtKB=Q90694	Cell division control protein 42 homolog	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IGI	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MONDO|Ensembl=ENSMODG00000025248|UniProtKB=F7F5X1	Uncharacterized protein	ISS	99084794	PubMed	PTHR24070:SF186	GTPASE KRAS
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01153	GSK3	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CAEEL|WormBase=WBGene00004037|UniProtKB=Q9XWB7	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF9	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00018	EGF receptor signaling pathway	P00558	SOS	NEUCR|EnsemblGenome=EFNCRG00000006179|UniProtKB=Q7RYH5	Cell division control protein 25	ISS			PTHR23113:SF315	CELL DIVISION CONTROL PROTEIN 25-RELATED
P00018	EGF receptor signaling pathway	P00557	PI3K	SCHPO|PomBase=SPAC458.05|UniProtKB=P50520	Phosphatidylinositol 3-kinase vps34	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00053	T cell activation	P01316	MHC-antigen	HUMAN|HGNC=4936|UniProtKB=P06340	HLA class II histocompatibility antigen, DO alpha chain	IPI	73139	PubMed	PTHR19944:SF44	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DO ALPHA CHAIN
P00021	FGF signaling pathway	P00627	ERK1-2	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	NAS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00047	PDGF signaling pathway	P01154	Ras	DANRE|ZFIN=ZDB-GENE-040718-293|UniProtKB=Q6DGU2	Uncharacterized protein	ISS			PTHR24073:SF581	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MOUSE|MGI=MGI=95821|UniProtKB=Q01097	Glutamate receptor ionotropic, NMDA 2B	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04397	p53 pathway by glucose deprivation	P04641	Akt	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	ISS	12719720	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IDA	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00193	SOS-1	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MONDO|Ensembl=ENSMODG00000023942|UniProtKB=F7F878	Uncharacterized protein	ISS	12441358	PubMed	PTHR24229:SF6	SOMATOSTATIN RECEPTOR TYPE 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	TAS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00030	Hypoxia response via HIF activation	P00819	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00474	Wnt	PANTR|Ensembl=ENSPTRG00000017278|UniProtKB=H2QRJ8	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	MACMU|Ensembl=ENSMMUG00000007427|UniProtKB=F6SX33	Rhodopsin kinase	ISS	8260489	PubMed	PTHR24355:SF11	RHODOPSIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00925	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00005	Angiogenesis	P00190	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	88318957	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P02787	Vitamin B6 metabolism	P03236	Pyridoxamine phosphate oxidase	SCHPO|PomBase=SPAC1093.02|UniProtKB=Q9UTQ1	Probable pyridoxamine 5'-phosphate oxidase	IEA	11859360	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IDA			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00048	PI3 kinase pathway	P01181	GSK3	STRPU|EnsemblGenome=SPU_009263|UniProtKB=W4Y0P1	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CHICK|Ensembl=ENSGALG00000014182|UniProtKB=O13076	Adenosine receptor A2b	IDA			PTHR24246:SF18	ADENOSINE RECEPTOR A2B
P00049	Parkinson disease	P01236	Casein kinase II	LEIMA|EnsemblGenome=LmjF.35.1730|UniProtKB=E9AEZ4	Putative casein kinase II	ISS	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00021	FGF signaling pathway	P00638	PLCgamma	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00057	Wnt signaling pathway	P01455	Smad4	BOVIN|Ensembl=ENSBTAG00000002835|UniProtKB=Q1JQA2	Mothers against decapentaplegic homolog 1	ISS	12736218	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05918	p38 MAPK pathway	P06026	MEKK4	HUMAN|HGNC=6856|UniProtKB=Q9Y6R4	Mitogen-activated protein kinase kinase kinase 4	IDA	11730323	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS	88311074	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00049	Parkinson disease	P01211	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	IDA	11790551	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	IDA	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P02736	Coenzyme A biosynthesis	P02885	Pantothenate kinase	RAT|RGD=628857|UniProtKB=Q923S8	Pantothenate kinase 4	ISS			PTHR12280:SF20	PANTOTHENATE KINASE 4
P00048	PI3 kinase pathway	P01177	P110ACT	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=88397|UniProtKB=Q9ERZ4	Muscarinic acetylcholine receptor M2	IDA	12181435	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	ARATH|TAIR=AT4G00720|UniProtKB=Q96287	Shaggy-related protein kinase theta	TAS			PTHR24057:SF19	SHAGGY-RELATED PROTEIN KINASE BETA-RELATED
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04556	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00648	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00018	EGF receptor signaling pathway	P00546	GAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	IGI	8262392	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00047	PDGF signaling pathway	P01142	p90RSK	ORNAN|Ensembl=ENSOANG00000010658|UniProtKB=F6V2V1	Uncharacterized protein	ISS	10480933	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	RAT|RGD=3187|UniProtKB=Q07008	Neurogenic locus notch homolog protein 1	IDA	1764995	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P04395	Vasopressin synthesis	P04589	Signal Peptidase	BOVIN|Ensembl=ENSBTAG00000011954|UniProtKB=Q2KI36	Signal peptidase complex catalytic subunit SEC11	ISS	2674115	PubMed	PTHR10806:SF12	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11C
P00038	JAK/STAT signaling pathway	P01027	STAT	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	ISS	12191995	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00047	PDGF signaling pathway	P01159	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	TAKRU|Ensembl=ENSTRUG00000013240|UniProtKB=H2U9T6	Inosine-5'-monophosphate dehydrogenase (Fragment)	ISS			PTHR11911:SF74	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MOUSE|MGI=MGI=95821|UniProtKB=Q01097	Glutamate receptor ionotropic, NMDA 2B	IC	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06841	gnaq/11	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	RCA	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	BOVIN|Gene=SOCS5|UniProtKB=Q29RN6	Suppressor of cytokine signaling 5	ISS	22247722	PubMed	PTHR44282:SF3	SUPPRESSOR OF CYTOKINE SIGNALING 5
P00010	B cell activation	P00384	p38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IDA	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00030	Hypoxia response via HIF activation	P00823	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00018	EGF receptor signaling pathway	P00562	p38	DANRE|ZFIN=ZDB-GENE-990415-257|UniProtKB=O42376	Mitogen-activated protein kinase 12	ISS	11707292	PubMed	PTHR24055:SF339	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-9966|UniProtKB=Q6TH03	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P02788	Xanthine and guanine salvage pathway	P03245	Guanine phosphoribosyl transferase	CANLF|Gene=HPRT1|UniProtKB=Q6WIT9	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF6	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE
P00047	PDGF signaling pathway	P01169	Vav	PANTR|Ensembl=ENSPTRG00000021525|UniProtKB=H2QY48	Uncharacterized protein	ISS	14623913	PubMed	PTHR22826:SF95	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00047	PDGF signaling pathway	P01154	Ras	MONDO|Ensembl=ENSMODG00000025248|UniProtKB=F7F5X1	Uncharacterized protein	ISS	99084794	PubMed	PTHR24070:SF186	GTPASE KRAS
P00021	FGF signaling pathway	P00638	PLCgamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	RAT|RGD=628830|UniProtKB=Q8CJE3	Myosin VIIA	ISS			PTHR13140:SF369	UNCONVENTIONAL MYOSIN-VIIA
P00047	PDGF signaling pathway	P01173	STAT	TAKRU|Ensembl=ENSTRUG00000000102|UniProtKB=H2RJA9	Signal transducer and activator of transcription	ISS	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00018	EGF receptor signaling pathway	P00539	14-3-3	CANLF|Ensembl=ENSCAFG00000009514|UniProtKB=F1PKW7	Uncharacterized protein	ISS	9055384	gi	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DROME|FlyBase=FBgn0000042|UniProtKB=P10987	Actin-5C	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	DANRE|ZFIN=ZDB-GENE-000328-4|UniProtKB=B0S6S2	Uncharacterized protein	TAS	11212302	PubMed	PTHR11309:SF90	FRIZZLED-8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	ARATH|TAIR=AT5G07880|UniProtKB=Q9SD96	SNAP25 homologous protein SNAP29	IC			PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P02781	Threonine biosynthesis	P03191	Homoserine kinase	THEMA|EnsemblGenome=TM_0545|UniProtKB=Q9WZ15	Homoserine kinase	ISS			PTHR20861:SF1	HOMOSERINE KINASE
P00056	VEGF signaling pathway	P01407	Erk	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00916	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00021	FGF signaling pathway	P00623	FGF	MACMU|Ensembl=ENSMMUG00000000949|UniProtKB=F6QYV4	Fibroblast growth factor	ISS	12815063	PubMed	PTHR11486:SF17	FIBROBLAST GROWTH FACTOR 12
P00018	EGF receptor signaling pathway	P00559	MEK1-2	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00019	Endothelin signaling pathway	P00589	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00021	FGF signaling pathway	P00627	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	8946911	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00047	PDGF signaling pathway	P01165	SRF	CAEEL|WormBase=WBGene00006844|UniProtKB=Q18955	Uncharacterized protein	ISS			PTHR11945:SF221	SERUM RESPONSE FACTOR
P04392	P53 pathway feedback loops 1	G04685	p73DeltaN	ORNAN|Ensembl=ENSOANG00000013795|UniProtKB=F7DUR2	Uncharacterized protein (Fragment)	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	PANTR|Ensembl=ENSPTRG00000003699|UniProtKB=H2Q3R5	Syntaxin 3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	HUMAN|HGNC=15906|UniProtKB=A7E2Y1	Myosin-7B	ISS	10938134	PubMed	PTHR13140:SF358	MYOSIN-7B
P00030	Hypoxia response via HIF activation	P00819	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	TAS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00951	Jnk	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00010	B cell activation	P00379	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00012	Cadherin signaling pathway	P00470	F-actin	CAEBR|Gene=CBG23090|UniProtKB=A8Y4R0	Protein CBG23090	ISS	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	HUMAN|HGNC=9283|UniProtKB=P36873	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	ISS	8392016	PubMed	PTHR11668:SF204	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-GAMMA CATALYTIC SUBUNIT
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	TAS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BOVIN|Ensembl=ENSBTAG00000005714|UniProtKB=Q3ZC07	Actin, alpha cardiac muscle 1	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	TAS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	IC	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00174	CD44 N-terminal fragment	RAT|RGD=2307|UniProtKB=P26051	CD44 antigen	IDA	12223485	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P00019	Endothelin signaling pathway	P00584	Gs	PANTR|Ensembl=ENSPTRG00000032488|UniProtKB=H2RDW0	Uncharacterized protein	RCA			PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00775	Rac	DROME|FlyBase=FBgn0010333|UniProtKB=P40792	Ras-related protein Rac1	TAS			PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00020	FAS signaling pathway	P00615	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	TAS	8946915	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	MACMU|Ensembl=ENSMMUG00000017654|UniProtKB=F6UI32	Beta-arrestin-2 isoform 1	ISS	9388255	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P02731	Biotin biosynthesis	P02858	8-Amino-7-oxononanoate synthase	AQUAE|EnsemblGenome=aq_626|UniProtKB=O66875	Putative 8-amino-7-oxononanoate synthase	ISS			PTHR13693:SF64	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00629	PP2A	MACMU|Ensembl=ENSMMUG00000004873|UniProtKB=F7ANY9	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00053	T cell activation	P01315	Calcineurin	XENTR|Xenbase=XB-GENE-952299|UniProtKB=B0BLZ8	Serine/threonine-protein phosphatase	ISS	12015605	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IDA	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	MACMU|Ensembl=ENSMMUG00000010574|UniProtKB=A5A6H2	C-fos	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00047	PDGF signaling pathway	P01162	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00010	B cell activation	P00398	IP3R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00047	PDGF signaling pathway	P01152	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	14707121	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P02742	Tetrahydrofolate biosynthesis	P02944	Phosphoribosylglycinamide formyltransferase	ARATH|TAIR=AT4G17360|UniProtKB=F4JP46	Formyltetrahydrofolate deformylase 2, mitochondrial	ISS			PTHR42706:SF1	FORMYLTETRAHYDROFOLATE DEFORMYLASE 1, MITOCHONDRIAL-RELATED
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2342|UniProtKB=P08482	Muscarinic acetylcholine receptor M1	IDA			PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P02724	Alanine biosynthesis	P02815	Branched chain amino acid aminotransferase	ARATH|TAIR=AT1G50110|UniProtKB=Q9LPM9	Branched-chain-amino-acid aminotransferase 6	ISS			PTHR42825:SF4	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 6-RELATED
P00029	Huntington disease	P00776	c-Jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=11334|UniProtKB=P35346	Somatostatin receptor type 5	IDA	12181435	PubMed	PTHR24229:SF20	SOMATOSTATIN RECEPTOR TYPE 5
P00047	PDGF signaling pathway	P01142	p90RSK	HUMAN|HGNC=10430|UniProtKB=Q15418	Ribosomal protein S6 kinase alpha-1	ISS	12213813	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	ORNAN|Ensembl=ENSOANG00000000979|UniProtKB=F6XKQ2	Glutamine synthetase	ISS			PTHR20852:SF45	GLUTAMINE SYNTHETASE
P00029	Huntington disease	P00790	beta-Tubulin	EMENI|EnsemblGenome=CADANIAG00001443|UniProtKB=P10653	Tubulin beta-1 chain	TAS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05734	Synaptic vesicle trafficking	P05779	Synaptobrevin	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02778	Sulfate assimilation	P03167	Sulfate adenylyltransferase	PANTR|Ensembl=ENSPTRG00000023677|UniProtKB=H2R2G5	Uncharacterized protein	ISS			PTHR11055:SF16	BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE 2
P05916	Opioid prodynorphin pathway	P06002	G-protein	TAKRU|Ensembl=ENSTRUG00000007253|UniProtKB=H2SZQ1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00029	Huntington disease	P00807	Actin	ASHGO|EnsemblGenome=AGOS_ABR222W|UniProtKB=Q75D00	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00056	VEGF signaling pathway	P01408	Akt/PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	G01535	PIG3	DEIRA|EnsemblGenome=DR_A0251|UniProtKB=Q9RYQ7	NADPH quinone oxidoreductase, putative	TAS			PTHR43677:SF4	QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2
P00047	PDGF signaling pathway	P01143	ERK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00034	Integrin signalling pathway	P00941	Integrin alpha	MOUSE|MGI=MGI=96600|UniProtKB=Q62469	Integrin alpha-2	IPI	3487386	PubMed	PTHR23220:SF23	INTEGRIN ALPHA-2
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04556	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	3449797	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	IC	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8971|UniProtKB=O00443	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00757	beta-arrestin	BOVIN|Ensembl=ENSBTAG00000021480|UniProtKB=P08168	S-arrestin	IDA	11742073	PubMed	PTHR11792:SF15	S-ARRESTIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00052	TGF-beta signaling pathway	P01290	TAB	MACMU|Ensembl=ENSMMUG00000012103|UniProtKB=F7H8X1	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform alpha	ISS	10838074	PubMed	PTHR13832:SF533	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IDA	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01062	mGluR1	MOUSE|MGI=MGI=1351342|UniProtKB=Q3UVX5	Metabotropic glutamate receptor 5	ISS			PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00053	T cell activation	P01312	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IDA	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00474	Wnt	DROME|FlyBase=FBgn0004360|UniProtKB=P28465	Protein Wnt-2	IDA	8717036	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05913	Enkephalin release	P05974	G-Protein (i)	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04393	Ras Pathway	P04547	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	8838318	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00018	EGF receptor signaling pathway	P00547	PP2A	XENTR|Xenbase=XB-GENE-484003|UniProtKB=Q6P365	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00010	B cell activation	P00385	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CHICK|Ensembl=ENSGALG00000009844|UniProtKB=P68034	Actin, alpha cardiac muscle 1	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00005	Angiogenesis	P00191	TF	HUMAN|HGNC=3541|UniProtKB=P13726	Tissue factor	IGI	4503641	gi	PTHR20859:SF22	TISSUE FACTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	MOUSE|MGI=MGI=2385459|UniProtKB=O54928	Suppressor of cytokine signaling 5	IDA	15032587	PubMed	PTHR44282:SF3	SUPPRESSOR OF CYTOKINE SIGNALING 5
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00035	Interferon-gamma signaling pathway	P00956	SOCS	HUMAN|HGNC=16833|UniProtKB=O14544	Suppressor of cytokine signaling 6	TAS	15032587	PubMed	PTHR44562:SF1	SUPPRESSOR OF CYTOKINE SIGNALING 6
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	91056091	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P02743	Formyltetrahydroformate biosynthesis	P02954	Thymidylate synthase	PSEAE|EnsemblGenome=PA0342|UniProtKB=Q9I6F1	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	TAS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IDA	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	BOVIN|Ensembl=ENSBTAG00000034854|UniProtKB=F1N246	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHICK|Ensembl=ENSGALG00000014620|UniProtKB=F1N8P3	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ANOGA|EnsemblGenome=AGAP001676|UniProtKB=Q7PXZ8	AGAP001676-PA	IC	10974003	PubMed	PTHR11937:SF368	ACTIN, INDIRECT FLIGHT MUSCLE
P00056	VEGF signaling pathway	P01411	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	IC	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00036	Interleukin signaling pathway	P00981	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	TAS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00047	PDGF signaling pathway	P01167	Ets	XENTR|Xenbase=XB-GENE-6085047|UniProtKB=B4F6M4	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF216	TRANSCRIPTIONAL REGULATOR ERG
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g242065|UniProtKB=A7S0V7	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT1G59580|UniProtKB=Q39022	Mitogen-activated protein kinase 2	ISS	10851062	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00641	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00053	T cell activation	P01324	rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00021	FGF signaling pathway	P00623	FGF	MONDO|Ensembl=ENSMODG00000009670|UniProtKB=F6SHQ2	Fibroblast growth factor	ISS			PTHR11486:SF71	FIBROBLAST GROWTH FACTOR 17
P00049	Parkinson disease	P01211	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	P04609	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	ISS	12660731	PubMed	PTHR10048:SF14	PI-3 KINASE
P05916	Opioid prodynorphin pathway	P06002	G-protein	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00035	Interferon-gamma signaling pathway	P00961	STAT1	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00007	Axon guidance mediated by semaphorins	P00336	Cdk5	DROME|FlyBase=FBgn0013762|UniProtKB=P48609	Cyclin-dependent kinase 5 homolog	ISS			PTHR24056:SF46	CYCLIN-DEPENDENT-LIKE KINASE 5
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	PANTR|Gene=ALDOA|UniProtKB=A5A6I5	Fructose-bisphosphate aldolase A	ISS	3391172	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P02738	De novo purine biosynthesis	P02891	GDP kinase	DICDI|dictyBase=DDB_G0273069|UniProtKB=P22887	Nucleoside diphosphate kinase, cytosolic	ISS			PTHR11349:SF64	NUCLEOSIDE DIPHOSPHATE KINASE HOMOLOG 5
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	BRAFL|Gene=BRAFLDRAFT_121298|UniProtKB=C3Z299	Putative uncharacterized protein	ISS			PTHR42884:SF13	NEUROENDOCRINE CONVERTASE 2
P00021	FGF signaling pathway	P00628	JNK1-3	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CAEBR|Gene=CBG02401|UniProtKB=A8WUE7	Protein CBR-NMR-1	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P06215	MYO signaling pathway	P06314	SMOX	DROME|FlyBase=FBgn0025800|UniProtKB=O96660	Mothers against decapentaplegic homolog	IEA	http://flybase.org/reports/FBrf0190369.html	Website	PTHR13703:SF25	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000010069|UniProtKB=H2QEM1	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF84	CADHERIN-20
P00016	Cytoskeletal regulation by Rho GTPase	P00525	N-WASP	PANTR|Ensembl=ENSPTRG00000019640|UniProtKB=H2QVA9	Uncharacterized protein	ISS	12932731	PubMed	PTHR23202:SF39	NEURAL WISKOTT-ALDRICH SYNDROME PROTEIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-040426-2280|UniProtKB=Q6P025	Gnb3 protein	ISS			PTHR19850:SF35	GNB3 PROTEIN
P00049	Parkinson disease	P01211	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MACMU|Ensembl=ENSMMUG00000012069|UniProtKB=F7HDK4	Transforming growth factor beta-3 preproprotein	ISS	9759503	PubMed	PTHR11848:SF34	TRANSFORMING GROWTH FACTOR BETA-3
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	MONDO|Ensembl=ENSMODG00000016680|UniProtKB=F7DMI7	Uncharacterized protein	ISS	Q90635	SPACC	PTHR11647:SF56	DIHYDROPYRIMIDINASE-RELATED PROTEIN 2
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	CAEBR|Gene=CBG02059|UniProtKB=A8WRW6	Protein CBR-UNC-2 (Fragment)	ISS	8386525	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P06959	CCKR signaling map	P07106	IRS1	HUMAN|HGNC=6125|UniProtKB=P35568	Insulin receptor substrate 1	RCA	8824290	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00053	T cell activation	P01316	MHC-antigen	RAT|RGD=6502739|UniProtKB=Q6MGA7	Hla-dmb protein	IPI	3112582	PubMed	PTHR19944:SF65	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DM BETA CHAIN
P00034	Integrin signalling pathway	P00951	Jnk	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DANRE|ZFIN=ZDB-GENE-040426-1354|UniProtKB=Q7T2C5	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00038	JAK/STAT signaling pathway	P01027	STAT	MOUSE|MGI=MGI=103062|UniProtKB=P42228	Signal transducer and activator of transcription 4	ISS	94255416	PubMed	PTHR11801:SF19	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 4
P02776	Serine glycine biosynthesis	P03159	Phosphoserine phosphatase	HUMAN|HGNC=9577|UniProtKB=P78330	Phosphoserine phosphatase	ISS			PTHR43344:SF2	PHOSPHOSERINE PHOSPHATASE
P00010	B cell activation	P00384	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CANLF|Ensembl=ENSCAFG00000015800|UniProtKB=F1Q4E3	Uncharacterized protein	ISS			PTHR13140:SF273	UNCONVENTIONAL MYOSIN-VA
P02734	Chorismate biosynthesis	P02872	3-Dehydroquinate synthase	FUSNN|EnsemblGenome=FN0871|UniProtKB=Q8RF47	Bifunctional 3-dehydroquinate synthase/phosphatase	ISS			PTHR43622:SF1	3-DEHYDROQUINATE SYNTHASE
P00018	EGF receptor signaling pathway	P00556	PLCgamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IGI	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00010	B cell activation	P00372	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	10521483	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	RCA	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01165	SRF	BOVIN|Ensembl=ENSBTAG00000012777|UniProtKB=E1BJP4	Uncharacterized protein	ISS	8660892	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P02734	Chorismate biosynthesis	P02870	3-Phosphoshikimate-1-carboxyvinyl transferase	ARATH|TAIR=AT1G48860|UniProtKB=Q9FVP6	3-phosphoshikimate 1-carboxyvinyltransferase	ISS			PTHR21090:SF5	PENTAFUNCTIONAL AROM POLYPEPTIDE
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	DROME|FlyBase=FBgn0016797|UniProtKB=Q9VVX3	Frizzled-2	TAS	8717036	PubMed	PTHR11309:SF90	FRIZZLED-8
P00034	Integrin signalling pathway	P00912	Arp2/3	MONDO|Ensembl=ENSMODG00000011628|UniProtKB=F6U132	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00045	Notch signaling pathway	P01105	TACE	RAT|RGD=620404|UniProtKB=Q9Z1K9	Disintegrin and metalloproteinase domain-containing protein 17	ISS	9774383	PubMed	PTHR11905:SF171	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	IDA	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05912	Dopamine receptor mediated signaling pathway	P05947	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00012	Cadherin signaling pathway	P00474	Wnt	RAT|RGD=621463|UniProtKB=G3V819	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00036	Interleukin signaling pathway	P00990	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00788	Calpain	MACMU|Ensembl=ENSMMUG00000006658|UniProtKB=F7H3Z3	Uncharacterized protein	ISS	11675509	PubMed	PTHR10183:SF22	CALPAIN-7
P00060	Ubiquitin proteasome pathway	P01491	E2	MACMU|Ensembl=ENSMMUG00000008223|UniProtKB=F6VEY1	Uncharacterized protein	ISS			PTHR43915:SF3	UBIQUITIN-CONJUGATING ENZYME E2 VARIANT 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	RAT|RGD=3146|UniProtKB=Q63358	Unconventional myosin-IXb	IC			PTHR13140:SF306	UNCONVENTIONAL MYOSIN-IXB
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00789	PSD-95	HUMAN|HGNC=2903|UniProtKB=P78352	Disks large homolog 4	RCA			PTHR23119:SF33	DISKS LARGE HOMOLOG 4
P00054	Toll receptor signaling pathway	P01357	MEKK1	PANTR|Ensembl=ENSPTRG00000016891|UniProtKB=H2R5K3	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00006	Apoptosis signaling pathway	P00269	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	MONDO|Gene=TSHB|UniProtKB=Q95J88	Thyrotropin subunit beta	ISS	5101174	PubMed	PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	MOUSE|MGI=MGI=106217|UniProtKB=Q61290	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	11976940	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00029	Huntington disease	P00774	Dynein complex	HUMAN|HGNC=2962|UniProtKB=Q8NCM8	Cytoplasmic dynein 2 heavy chain 1	ISS	9454836	PubMed	PTHR10676:SF352	CYTOPLASMIC DYNEIN 2 HEAVY CHAIN 1
P00053	T cell activation	P01336	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000016727|UniProtKB=F6VCS5	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF1	CADHERIN-16
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P06211	BMP/activin signaling pathway-drosophila	P06245	R-Smad	DROME|FlyBase=FBgn0011648|UniProtKB=P42003	Protein mothers against dpp	RCA			PTHR13703:SF40	PROTEIN MOTHERS AGAINST DPP
P00006	Apoptosis signaling pathway	P00269	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00023	General transcription regulation	P00658	TBP-associated factors	CANLF|Ensembl=ENSCAFG00000001239|UniProtKB=E2RFN3	Uncharacterized protein	ISS			PTHR13218:SF8	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11
P04393	Ras Pathway	P04541	p90RSK	PANTR|Ensembl=ENSPTRG00000000387|UniProtKB=H2PYE3	Ribosomal protein S6 kinase	ISS	7688567	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00012	Cadherin signaling pathway	P00462	Casein kinase II	TAKRU|Ensembl=ENSTRUG00000016144|UniProtKB=H2UWE3	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00005	Angiogenesis	P00243	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	RCA	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00006	Apoptosis signaling pathway	P00260	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	NAS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00778	NMDA receptor	HUMAN|HGNC=4588|UniProtKB=O15399	Glutamate receptor ionotropic, NMDA 2D	IDA	11319238	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IDA	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00048	PI3 kinase pathway	P01199	Galpha	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IC	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P02723	Adenine and hypoxanthine salvage pathway	P02808	Deoxyadenosine phosphorylase	DROME|FlyBase=FBgn0035348|UniProtKB=M9PE19	Uncharacterized protein, isoform H	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00049	Parkinson disease	P01219	SAPK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	ISS	10571227	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ARATH|TAIR=AT5G59370|UniProtKB=P53494	Actin-4	ISS	11889126	PubMed	PTHR11937:SF366	ACTIN-4
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	HUMAN|HGNC=7881|UniProtKB=P46531	Neurogenic locus notch homolog protein 1	IDA	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-040426-2427|UniProtKB=F1Q6C0	Uncharacterized protein (Fragment)	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00245	Rac	MOUSE|MGI=MGI=1920417|UniProtKB=Q9CXP4	Rho GTPase-activating protein 8	ISS			PTHR23176:SF3	PROTEIN PRR5-ARHGAP8-RELATED
P00010	B cell activation	P00392	I kappa B	RAT|RGD=3171|UniProtKB=Q63746	NF-kappa-B inhibitor alpha	ISS	99081292	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	DROME|FlyBase=FBgn0027493|UniProtKB=Q9Y0Y2	Adenylosuccinate synthetase	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	HUMAN|HGNC=10451|UniProtKB=P23921	Ribonucleoside-diphosphate reductase large subunit	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P05730	Endogenous cannabinoid signaling	P05746	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	HUMAN|HGNC=7881|UniProtKB=P46531	Neurogenic locus notch homolog protein 1	IDA	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	TAKRU|Ensembl=ENSTRUG00000009259|UniProtKB=H2TF39	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00047	PDGF signaling pathway	P01169	Vav	CANLF|Ensembl=ENSCAFG00000018590|UniProtKB=E2RGT8	Uncharacterized protein	ISS	10661401	PubMed	PTHR22826:SF112	PROTO-ONCOGENE VAV
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CAEEL|WormBase=WBGene00004039|UniProtKB=Q21754	Phosphoinositide phospholipase C	ISS			PTHR10336:SF147	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-2
P00025	Hedgehog signaling pathway	P00682	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00573	signal peptidase	ARATH|TAIR=AT3G15710|UniProtKB=Q9LW08	Signal peptidase I	ISS	2674115	PubMed	PTHR10806:SF6	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11
P00029	Huntington disease	P00775	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	MOUSE|MGI=MGI=88296|UniProtKB=O55017	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	15079861	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00010	B cell activation	P00376	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	NEUCR|EnsemblGenome=EFNCRG00000000159|UniProtKB=F5HH30	Guanine nucleotide-binding protein beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00875	GEF	MOUSE|MGI=MGI=3040696|UniProtKB=Q69ZK0	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein	ISS	11955434	PubMed	PTHR22829:SF6	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE-DEPENDENT RAC EXCHANGER 1 PROTEIN
P00052	TGF-beta signaling pathway	P01292	RSmads	MOUSE|MGI=MGI=108051|UniProtKB=Q62432	Mothers against decapentaplegic homolog 2	TAS	9395284	PubMed	PTHR13703:SF42	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000024992|UniProtKB=F6TUR3	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P02747	Histidine biosynthesis	P02984	Imidazol glycerol phosphate dehydratase	BACTN|EnsemblGenome=BT_0203|UniProtKB=Q8ABA7	Histidine biosynthesis bifunctional protein HisB	ISS			PTHR23133:SF2	IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE
P00011	Blood coagulation	P00414	Thrombin	CHICK|Ensembl=ENSGALG00000008332|UniProtKB=F1NXV6	Prothrombin	ISS	289825	gi	PTHR24254:SF10	PROTHROMBIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MOUSE|MGI=MGI=1339712|UniProtKB=P13542	Myosin-8	ISS	10938134	PubMed	PTHR13140:SF368	MYOSIN-8
P00047	PDGF signaling pathway	P01150	PKC	MACMU|Ensembl=ENSMMUG00000020588|UniProtKB=F7C0E0	Uncharacterized protein	ISS	10644715	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01143	ERK	RAT|RGD=62087|UniProtKB=P27704	Mitogen-activated protein kinase 6	ISS	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00053	T cell activation	P01312	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05915	Opioid proenkephalin pathway	P05994	G-protein	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00005	Angiogenesis	P00187	beta catenin	MACMU|Ensembl=ENSMMUG00000014627|UniProtKB=F7GNE4	Catenin beta-1	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00059	p53 pathway	G01579	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P05913	Enkephalin release	P05972	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00586	Gq	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P02784	Tyrosine biosynthesis	P03214	Prephenate dehydrogenase	BACSU|EnsemblGenome=BSU22610|UniProtKB=P20692	Prephenate dehydrogenase	ISS			PTHR21363:SF0	PREPHENATE DEHYDROGENASE  NADP +
P00006	Apoptosis signaling pathway	P00302	ATF	HUMAN|HGNC=17546|UniProtKB=Q8WYK2	Jun dimerization protein 2	ISS			PTHR23351:SF10	JUN DIMERIZATION PROTEIN 2
P00049	Parkinson disease	P01242	Casein kinase I	MACMU|Ensembl=ENSMMUG00000010122|UniProtKB=F7HF84	Casein kinase I isoform epsilon	ISS	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	TAS	11554554	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00029	Huntington disease	P00790	beta-Tubulin	MOUSE|MGI=MGI=1915472|UniProtKB=P68372	Tubulin beta-4B chain	TAS	9454836	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00057	Wnt signaling pathway	P01446	Calcineurin	HUMAN|HGNC=9315|UniProtKB=P16298	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	IDA	7532676	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P04398	p53 pathway feedback loops 2	P04665	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DICDI|dictyBase=DDB_G0274383|UniProtKB=Q8MLZ3	cGMP-dependent 3',5'-cGMP phosphodiesterase A	IC	2372396	PubMed	PTHR45452:SF1	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05913	Enkephalin release	P05975	GPCR (s)	RAT|RGD=3234|UniProtKB=P33535	Mu-type opioid receptor	ISS	11259487	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MACMU|Ensembl=ENSMMUG00000017683|UniProtKB=F6UA63	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	ISS	12655147	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01315	Calcineurin	HUMAN|HGNC=9314|UniProtKB=Q08209	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	IGI	12091710	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P05913	Enkephalin release	P05974	G-Protein (i)	XENTR|Xenbase=XB-GENE-969601|UniProtKB=Q28H40	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00019	Endothelin signaling pathway	P00566	ERK	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	NAS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05915	Opioid proenkephalin pathway	P05994	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00562	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00053	T cell activation	P01312	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04397	p53 pathway by glucose deprivation	P04636	S6K	MOUSE|MGI=MGI=1270849|UniProtKB=Q8BSK8	Ribosomal protein S6 kinase beta-1	IDA	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00019	Endothelin signaling pathway	P00566	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DANRE|ZFIN=ZDB-GENE-030131-1229|UniProtKB=Q6DHS1	Actin, alpha 2, smooth muscle, aorta	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	RAT|RGD=2747|UniProtKB=P35349	Metabotropic glutamate receptor 6	ISS	12351712	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MACMU|Ensembl=ENSMMUG00000010392|UniProtKB=F7ASR8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00007	Axon guidance mediated by semaphorins	P00330	CRAM	RAT|RGD=620467|UniProtKB=Q9JHU0	Dihydropyrimidinase-related protein 5	ISS	11034345	PubMed	PTHR11647:SF58	DIHYDROPYRIMIDINASE-RELATED PROTEIN 5
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04396	Vitamin D metabolism and pathway	P04605	P450 reductase	SCHPO|PomBase=SPBC29A10.01|UniProtKB=P36587	NADPH--cytochrome P450 reductase	TAS	2513880	PubMed	PTHR19384:SF17	NADPH--CYTOCHROME P450 REDUCTASE
P00012	Cadherin signaling pathway	P00474	Wnt	BOVIN|Ensembl=ENSBTAG00000012914|UniProtKB=F1MHG3	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00006	Apoptosis signaling pathway	P00274	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	RCA	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P02721	ATP synthesis	P02791	F1 alpha	STRPU|EnsemblGenome=SPU_017605|UniProtKB=W4YP78	ATP synthase subunit alpha	ISS	9540069	PubMed	PTHR43089:SF5	ATP SYNTHASE SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00004	Alzheimer disease-presenilin pathway	P00113	Erb-B4 transmembrane fragment	MONDO|Ensembl=ENSMODG00000015755|UniProtKB=F6ZSZ9	Uncharacterized protein (Fragment)	ISS	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00001	Adrenaline and noradrenaline biosynthesis	P00062	TH	PANTR|Ensembl=ENSPTRG00000003173|UniProtKB=H2Q2W7	Uncharacterized protein	ISS	191290	OMIM	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01095	beta	HUMAN|HGNC=1961|UniProtKB=P11230	Acetylcholine receptor subunit beta	ISS	22213672	PubMed	PTHR18945:SF477	ACETYLCHOLINE RECEPTOR SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00554	Shc	RAT|RGD=69348|UniProtKB=O70143	SHC-transforming protein 3	ISS	98175964	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P04392	P53 pathway feedback loops 1	P04538	Pirh-2	PANTR|Ensembl=ENSPTRG00000016170|UniProtKB=H2QPP6	Ring finger and CHY zinc finger domain containing 1	ISS	607680	OMIM	PTHR21319:SF20	RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1
P00029	Huntington disease	P00787	MAPKK4	MACMU|Ensembl=ENSMMUG00000019842|UniProtKB=F7FU91	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	DANRE|ZFIN=ZDB-GENE-000403-1|UniProtKB=P57094	Axin-1	IEP	12356903	PubMed	PTHR10845:SF11	AXIN-1
P04371	5-Hydroxytryptamine biosynthesis	P04399	Tryptophan hydroxylase	HUMAN|HGNC=20692|UniProtKB=Q8IWU9	Tryptophan 5-hydroxylase 2	ISS	14597720	PubMed	PTHR11473:SF16	TRYPTOPHAN 5-HYDROXYLASE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00012	Cadherin signaling pathway	P00474	Wnt	RAT|RGD=1304559|UniProtKB=D4A3W9	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P00006	Apoptosis signaling pathway	P00269	MAPK	ORYSJ|EnsemblGenome=OS06G0699400|UniProtKB=Q5Z859	Mitogen-activated protein kinase 4	ISS	10851062	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00060	Ubiquitin proteasome pathway	P01494	19S proteasome	HUMAN|HGNC=9551|UniProtKB=P43686	26S protease regulatory subunit 6B	ISS			PTHR23073:SF8	26S PROTEASE REGULATORY SUBUNIT 6B
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_115566|UniProtKB=C3XYC8	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MACMU|Ensembl=ENSMMUG00000017683|UniProtKB=F6UA63	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00018	EGF receptor signaling pathway	P00539	14-3-3	ORYSJ|EnsemblGenome=OS11G0546900|UniProtKB=Q2R2W2	14-3-3-like protein GF14-D	ISS	10407019	PubMed	PTHR18860:SF34	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00632	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00012	Cadherin signaling pathway	P00470	F-actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347740|UniProtKB=E9FXV8	Cytoplasmatic actin	ISS	10974003	PubMed	PTHR11937:SF277	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00556	PLCgamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	RCA	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01189	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	TAS	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00024	Glycolysis	P00678	Enolase	MACMU|Ensembl=ENSMMUG00000009443|UniProtKB=F6X1V9	Gamma-enolase	ISS	86042683	PubMed	PTHR11902:SF10	GAMMA-ENOLASE
P00053	T cell activation	P01331	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IDA	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00006	Apoptosis signaling pathway	P00325	Bim	PANTR|Ensembl=ENSPTRG00000023320|UniProtKB=H2R0F7	Bcl-2-like protein 11	ISS	11859372	PubMed	PTHR12044:SF9	BCL-2-LIKE PROTEIN 11
P00022	General transcription by RNA polymerase I	P00649	TAF-IC	PANTR|Ensembl=ENSPTRG00000008411|UniProtKB=H2QBM1	Uncharacterized protein	ISS	604905	OMIM	PTHR15319:SF1	TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT C
P00045	Notch signaling pathway	P01119	NIct	PANTR|Ensembl=ENSPTRG00000034379|UniProtKB=H2RDK4	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P00019	Endothelin signaling pathway	P00587	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00252	Grb2	CAEEL|WormBase=WBGene00004774|UniProtKB=P29355	Sex muscle abnormal protein 5	ISS			PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00056	VEGF signaling pathway	P01408	Akt/PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00961	STAT1	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	TAS	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IDA	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00018	EGF receptor signaling pathway	P00558	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00010	B cell activation	P00391	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IGI	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00036	Interleukin signaling pathway	P00975	RasGAP	HUMAN|HGNC=9871|UniProtKB=P20936	Ras GTPase-activating protein 1	IC	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00029	Huntington disease	P00780	Microtubule	PRIPA|Gene=PPA02894|UniProtKB=H3DZP3	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF120	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01148	Grb2	MACMU|Ensembl=ENSMMUG00000000828|UniProtKB=F6Q223	GRB2-associated-binding protein 1 isoform a	ISS			PTHR12156:SF18	GRB2-ASSOCIATED-BINDING PROTEIN 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000004742|UniProtKB=H2Q5K1	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00833	RGS	RAT|RGD=1305515|UniProtKB=F1M0G0	Protein Rgs17	ISS	8756726	PubMed	PTHR10845:SF196	REGULATOR OF G-PROTEIN SIGNALING 17
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	HUMAN|HGNC=10935|UniProtKB=Q05940	Synaptic vesicular amine transporter	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00047	PDGF signaling pathway	P01174	Rho	MOUSE|MGI=MGI=2445003|UniProtKB=Q5FWK3	Rho GTPase-activating protein 1	ISS	14724572	PubMed	PTHR23176:SF28	RHO GTPASE-ACTIVATING PROTEIN 1
P00024	Glycolysis	P00679	Aldolase	RAT|RGD=1359133|UniProtKB=Q6AY07	Fructose-bisphosphate aldolase	ISS	4812352	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04665	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P05734	Synaptic vesicle trafficking	P05779	Synaptobrevin	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	RCA	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04395	Vasopressin synthesis	P04596	Endo Peptidase	CHICK|Ensembl=ENSGALG00000015405|UniProtKB=F1NUS2	Uncharacterized protein	IC	9695945	PubMed	PTHR42881:SF2	PROLYL ENDOPEPTIDASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IDA	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05918	p38 MAPK pathway	P05922	MKP1	MACMU|Ensembl=ENSMMUG00000008844|UniProtKB=F7ES52	Dual specificity protein phosphatase	ISS			PTHR10159:SF309	DUAL SPECIFICITY PROTEIN PHOSPHATASE 1
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00019	Endothelin signaling pathway	P00580	ET-RA/B	CANLF|Gene=EDNRA|UniProtKB=Q5KSU9	Endothelin-1 receptor	ISS	12538737	PubMed	PTHR24243:SF31	ENDOTHELIN-1 RECEPTOR
P04393	Ras Pathway	P04564	MAPKAP	CHICK|Ensembl=ENSGALG00000000883|UniProtKB=F1NCY7	Uncharacterized protein	ISS			PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	TAS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P02740	De novo pyrimidine ribonucleotides biosythesis	P02928	Dihydroorotase	FUSNN|EnsemblGenome=FN0420|UniProtKB=Q8RG88	Dihydroorotase	ISS			PTHR43668:SF1	SUBFAMILY NOT NAMED
P00011	Blood coagulation	P00433	uPAR	BOVIN|Ensembl=ENSBTAG00000013125|UniProtKB=Q05588	Urokinase plasminogen activator surface receptor	ISS	465002	gi	PTHR10624:SF6	UROKINASE PLASMINOGEN ACTIVATOR SURFACE RECEPTOR
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	TAKRU|Ensembl=ENSTRUG00000008289|UniProtKB=H2T7U8	Uncharacterized protein	ISS	11027488	PubMed	PTHR24072:SF129	CDC42L PROTEIN
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-990415-257|UniProtKB=O42376	Mitogen-activated protein kinase 12	TAS	11274345	PubMed	PTHR24055:SF339	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IDA	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ORNAN|Ensembl=ENSOANG00000000460|UniProtKB=F7F4W9	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00019	Endothelin signaling pathway	P00575	furin	MOUSE|MGI=MGI=97511|UniProtKB=P63239	Neuroendocrine convertase 1	ISS			PTHR42884:SF14	NEUROENDOCRINE CONVERTASE 1
P00057	Wnt signaling pathway	P01456	beta-arrestin	BOVIN|Gene=ARRB2|UniProtKB=P32120	Beta-arrestin-2	IDA	11742073	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P04395	Vasopressin synthesis	P04594	Neurophysin	MOUSE|MGI=MGI=97453|UniProtKB=P35454	Oxytocin-neurophysin 1	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00009	Axon guidance mediated by netrin	P00359	NFAT	MACMU|Ensembl=ENSMMUG00000021843|UniProtKB=F6RNI3	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00051	TCA cycle	P01269	alphaketoglutarate Dehydrogenase	RAT|RGD=1561359|UniProtKB=Q5XI78	2-oxoglutarate dehydrogenase, mitochondrial	ISS	12477932	PubMed	PTHR23152:SF7	2-OXOGLUTARATE DEHYDROGENASE, MITOCHONDRIAL
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	IDA	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01311	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	IDA	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00010	B cell activation	P00369	MEKK	HUMAN|HGNC=6855|UniProtKB=Q99759	Mitogen-activated protein kinase kinase kinase 3	IDA	11730323	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P04398	p53 pathway feedback loops 2	P04651	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P00030	Hypoxia response via HIF activation	P00824	PTEN	TAKRU|Ensembl=ENSTRUG00000009851|UniProtKB=H2TJ90	Uncharacterized protein	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00019	Endothelin signaling pathway	P00583	cPLA2	DANRE|ZFIN=ZDB-GENE-990415-45|UniProtKB=P50392	Cytosolic phospholipase A2	IGI	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	SCHPO|PomBase=SPCC1682.10|UniProtKB=O74440	26S proteasome regulatory subunit rpn8	ISS	21848401	PubMed	PTHR10540:SF7	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00586	Gq	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00477	GSK3beta	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	IDA	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	G04700	PAI	MOUSE|MGI=MGI=97608|UniProtKB=P22777	Plasminogen activator inhibitor 1	ISS	6981332	gi	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=619742|UniProtKB=F1MAH6	Protein Cdh11	ISS	8120095	PubMed	PTHR24027:SF85	CADHERIN-11
P00053	T cell activation	P01336	Jnk	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	21150461	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	TAS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00018	EGF receptor signaling pathway	P00556	PLCgamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00029	Huntington disease	P00782	alpha-Adaptin	MACMU|Ensembl=ENSMMUG00000003620|UniProtKB=F6QED1	Uncharacterized protein	ISS	11532990	PubMed	PTHR22780:SF4	AP-2 COMPLEX SUBUNIT ALPHA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00012	Cadherin signaling pathway	P00474	Wnt	MACMU|Ensembl=ENSMMUG00000015705|UniProtKB=F6SM00	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	CHICK|Ensembl=ENSGALG00000017238|UniProtKB=F1NWG3	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MOUSE|MGI=MGI=95822|UniProtKB=Q01098	Glutamate receptor ionotropic, NMDA 2C	IC	14698601	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00057	Wnt signaling pathway	P01450	Bcl9	MOUSE|MGI=MGI=1924828|UniProtKB=Q9D219	B-cell CLL/lymphoma 9 protein	ISS	11955446	PubMed	PTHR15185:SF5	B-CELL CLL/LYMPHOMA 9 PROTEIN
P00023	General transcription regulation	P00660	RNA Polymerase II	DANRE|Ensembl=ENSDARG00000074274|UniProtKB=E7FDD7	Uncharacterized protein	ISS	11313498	gi	PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P00018	EGF receptor signaling pathway	P00547	PP2A	MONDO|Ensembl=ENSMODG00000002945|UniProtKB=F6PKB8	Uncharacterized protein	ISS	12110603	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00010	B cell activation	P00391	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2845|UniProtKB=P19327	5-hydroxytryptamine receptor 1A	IDA	2156831	PubMed	PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P00053	T cell activation	P01305	Calmodulin	ORYSJ|EnsemblGenome=OS01G0267900|UniProtKB=Q0JNS6	Calmodulin-1	ISS	9753452	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	CAEEL|WormBase=WBGene00006932|UniProtKB=Q9TXI7	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00010	B cell activation	P00381	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT1G10210|UniProtKB=Q39021	Mitogen-activated protein kinase 1	ISS	15218451	gi	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000004742|UniProtKB=H2Q5K1	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P05731	GABA-B receptor II signaling	P05760	AC	BOVIN|Ensembl=ENSBTAG00000005464|UniProtKB=E1B9K3	Uncharacterized protein	ISS	10978539	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00006	Apoptosis signaling pathway	P00324	NIK	PANTR|Ensembl=ENSPTRG00000034405|UniProtKB=H2RC20	Mitogen-activated protein kinase kinase kinase 14	ISS	9020361	PubMed	PTHR24361:SF226	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 14
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	SCHPO|PomBase=SPAC6G9.11|UniProtKB=Q92356	Synaptobrevin homolog 1	IC			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P02741	Flavin biosynthesis	P02936	FAD synthetase	DROME|FlyBase=FBgn0032522|UniProtKB=Q9VJY1	FI21750p1	RCA			PTHR23293:SF9	FAD SYNTHASE
P00019	Endothelin signaling pathway	P00585	ECE1-3	ANOGA|EnsemblGenome=AGAP007796|UniProtKB=Q7Q3B4	AGAP007796-PA	ISS			PTHR11733:SF160	FI17316P1-RELATED
P02731	Biotin biosynthesis	P02857	Biotin synthase	NEUCR|EnsemblGenome=EFNCRG00000003593|UniProtKB=Q7RXK2	Biotin synthase	ISS			PTHR22976:SF1	BIOTIN SYNTHASE, MITOCHONDRIAL
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000000323|UniProtKB=H2PYA3	Uncharacterized protein	ISS	14645495	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00021	FGF signaling pathway	P00647	SHP2	MACMU|Ensembl=ENSMMUG00000013253|UniProtKB=F6ZJD8	Tyrosine-protein phosphatase non-receptor type	ISS	14534538	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00057	Wnt signaling pathway	P01465	Ggamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	ARATH|TAIR=AT3G08530|UniProtKB=Q0WLB5	Clathrin heavy chain 2	IDA	9388255	PubMed	PTHR10292:SF1	CLATHRIN HEAVY CHAIN
P00034	Integrin signalling pathway	P00948	Rho	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	IGI	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00018	EGF receptor signaling pathway	P00547	PP2A	BRAFL|Gene=BRAFLDRAFT_123893|UniProtKB=C3XQF4	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00007	Axon guidance mediated by semaphorins	P00331	PAK	CANLF|Ensembl=ENSCAFG00000004956|UniProtKB=E2REH3	Uncharacterized protein	ISS	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	HUMAN|HGNC=1950|UniProtKB=P11229	Muscarinic acetylcholine receptor M1	ISS	11166329	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P04372	5-Hydroxytryptamine degredation	P04401	Monoamine Oxidase	CANLF|Gene=MAOB|UniProtKB=Q7YRB7	Amine oxidase [flavin-containing] B	ISS	8602220	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	MACMU|Ensembl=ENSMMUG00000010508|UniProtKB=F7B8E3	Uncharacterized protein	ISS			PTHR11405:SF38	CARBAMOYL-PHOSPHATE SYNTHASE  AMMONIA , MITOCHONDRIAL
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	14744428	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8709|UniProtKB=Q9Y5G2	Protocadherin gamma-B2	IDA	8120095	PubMed	PTHR24028:SF144	PROTOCADHERIN GAMMA-B2
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00010	B cell activation	P00397	IKK	RAT|RGD=1306661|UniProtKB=G3V926	Conserved helix-loop-helix ubiquitous kinase (Predicted)	ISS	12235208	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00949	Shc	MOUSE|MGI=MGI=98296|UniProtKB=P98083	SHC-transforming protein 1	IPI	95096035	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01294	NFAT	PANTR|Ensembl=ENSPTRG00000013628|UniProtKB=H2R4F5	Uncharacterized protein	ISS	12787506	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00049	Parkinson disease	P01211	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	ARATH|TAIR=AT1G01560|UniProtKB=Q9LMM5	Mitogen-activated protein kinase 11	TAS			PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	RAT|RGD=3139|UniProtKB=Q29RW1	Myosin-4	ISS	10938134	PubMed	PTHR13140:SF657	MYOSIN-4
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	PANTR|Gene=HTR1A|UniProtKB=Q9N298	5-hydroxytryptamine receptor 1A	ISS	12441358	PubMed	PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_127489|UniProtKB=C3XYC6	Putative uncharacterized protein	IDA	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00018	EGF receptor signaling pathway	P00564	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	RAT|RGD=2958|UniProtKB=P63251	G protein-activated inward rectifier potassium channel 1	ISS	2433589	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	CHICK|Ensembl=ENSGALG00000001334|UniProtKB=F1NLV4	Uncharacterized protein	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00057	Wnt signaling pathway	P01444	Wnt	RAT|RGD=1304988|UniProtKB=A0A0G2K6Q8	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00018	EGF receptor signaling pathway	P00541	Spry	RAT|RGD=1305324|UniProtKB=D3ZJA3	Protein Spry4	ISS	99264295	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P00029	Huntington disease	P00780	Microtubule	PHYPA|Gene=PHYPADRAFT_232451|UniProtKB=A9SKU2	Predicted protein	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000003399|UniProtKB=H2Q383	Phosphoinositide-3-kinase, class 2, alpha polypeptide	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00466	EGFR	CHICK|Ensembl=ENSGALG00000003126|UniProtKB=F1P258	Receptor protein-tyrosine kinase	ISS	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00060	Ubiquitin proteasome pathway	P01491	E2	CHICK|Ensembl=ENSGALG00000011292|UniProtKB=F1NFT6	Uncharacterized protein	ISS			PTHR43902:SF2	UBIQUITIN-CONJUGATING ENZYME E2 N
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	YEAST|SGD=S000000028|UniProtKB=P31109	Synaptobrevin homolog 1	ISS			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00054	Toll receptor signaling pathway	P01369	MKK1	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00006	Apoptosis signaling pathway	P00318	PKCs	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IDA	15572354	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00053	T cell activation	P01297	MEKK	MACMU|Ensembl=ENSMMUG00000012387|UniProtKB=F7EB20	Uncharacterized protein	RCA	12049732	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00034	Integrin signalling pathway	P00916	Ras	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	IPI	12104050	PubMed	PTHR24070:SF189	GTPASE NRAS
P00056	VEGF signaling pathway	P01411	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00035	Interferon-gamma signaling pathway	P00960	PTP	MOUSE|MGI=MGI=96055|UniProtKB=P29351	Tyrosine-protein phosphatase non-receptor type 6	TAS	14525967	PubMed	PTHR19134:SF65	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 6
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=1913316|UniProtKB=P61953	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	ISS			PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IDA	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00012	Cadherin signaling pathway	P00474	Wnt	BOVIN|Ensembl=ENSBTAG00000002664|UniProtKB=F1N7G3	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF84	PROTEIN WNT-9B
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00047	PDGF signaling pathway	P01145	c-fos	MACMU|Ensembl=ENSMMUG00000010574|UniProtKB=A5A6H2	C-fos	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CHICK|Ensembl=ENSGALG00000015835|UniProtKB=F1NZT2	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00034	Integrin signalling pathway	P00907	ERK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS			PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02738	De novo purine biosynthesis	P02902	ADP reductase	TRYB2|Gene=Tb11.v4.0005|UniProtKB=Q382Q2	Ribonucleoside-diphosphate reductase small chain	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00036	Interleukin signaling pathway	P00996	STAT	MONDO|Ensembl=ENSMODG00000028212|UniProtKB=F7BYN4	Signal transducer and activator of transcription	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P02743	Formyltetrahydroformate biosynthesis	P02953	Cobalamin dependent homocysteine transmethylase	ARATH|TAIR=AT3G22740|UniProtKB=Q8LAX0	Homocysteine S-methyltransferase 3	ISS			PTHR21091:SF159	HOMOCYSTEINE S-METHYLTRANSFERASE 3
P05916	Opioid prodynorphin pathway	P06002	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	RAT|RGD=1311928|UniProtKB=D3ZT83	Protein Slc1a7	ISS	94365697	PubMed	PTHR11958:SF22	EXCITATORY AMINO ACID TRANSPORTER 5
P05916	Opioid prodynorphin pathway	P05998	Kappa Receptor	MACMU|Ensembl=ENSMMUG00000018372|UniProtKB=F7H1J2	Uncharacterized protein	ISS	11259487	PubMed	PTHR24229:SF1	KAPPA-TYPE OPIOID RECEPTOR
P05917	Opioid proopiomelanocortin pathway	P06009	K+ channel	HUMAN|HGNC=6283|UniProtKB=Q9NPC2	Potassium channel subfamily K member 9	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	RCA	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	MOUSE|MGI=MGI=98728|UniProtKB=Q64729	TGF-beta receptor type-1	TAS	10683140	PubMed	PTHR23255:SF61	TGF-BETA RECEPTOR TYPE-1
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	RCA	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000014576|UniProtKB=H2QLZ9	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00006	Apoptosis signaling pathway	P00318	PKCs	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IDA	10747026	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IDA	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	CANLF|Ensembl=ENSCAFG00000000550|UniProtKB=F6V7Y8	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF196	REGULATOR OF G-PROTEIN SIGNALING 17
P00053	T cell activation	P01316	MHC-antigen	PANTR|Ensembl=ENSPTRG00000018016|UniProtKB=H2QSR4	Uncharacterized protein	ISS	73139	PubMed	PTHR19944:SF63	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN
P00047	PDGF signaling pathway	P01174	Rho	HUMAN|HGNC=674|UniProtKB=P98171	Rho GTPase-activating protein 4	ISS			PTHR14166:SF16	RHO GTPASE-ACTIVATING PROTEIN 4
P00020	FAS signaling pathway	P00601	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00048	PI3 kinase pathway	P01177	P110ACT	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	G01581	BAX	XENTR|Xenbase=XB-GENE-486067|UniProtKB=Q6P4Y4	BCL2-associated X protein	ISS	14963330	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04393	Ras Pathway	P04570	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01275	P38	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	TAS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	MONDO|Ensembl=ENSMODG00000009352|UniProtKB=F7G015	Uncharacterized protein	ISS	9783586	PubMed	PTHR10814:SF23	TRANSDUCIN-LIKE ENHANCER PROTEIN 1
P02781	Threonine biosynthesis	P03189	Aspartate kinase	ARATH|TAIR=AT5G21060|UniProtKB=F4K6Y8	Homoserine dehydrogenase	ISS			PTHR43070:SF4	HOMOSERINE DEHYDROGENASE
P05918	p38 MAPK pathway	P06021	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00005	Angiogenesis	P00211	GSK3beta	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00059	p53 pathway	P04630	PP2A	ANOGA|EnsemblGenome=AGAP010172|UniProtKB=Q7PD38	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04393	Ras Pathway	P04557	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	IDA	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00053	T cell activation	P01336	Jnk	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00005	Angiogenesis	P00249	PAK	RAT|RGD=3250|UniProtKB=P35465	Serine/threonine-protein kinase PAK 1	ISS	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00004	Alzheimer disease-presenilin pathway	P00170	Aph-1	PANTR|Ensembl=ENSPTRG00000007146|UniProtKB=H2Q9J9	Anterior pharynx defective 1 homolog B	ISS	12763021	PubMed	PTHR12889:SF1	GAMMA-SECRETASE SUBUNIT APH-1B
P00029	Huntington disease	P00766	Htt	MOUSE|MGI=MGI=96067|UniProtKB=P42859	Huntingtin	IDA	7620118	PubMed	PTHR10170:SF10	HUNTINGTIN
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00053	T cell activation	P01311	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P04393	Ras Pathway	P04564	MAPKAP	MOUSE|MGI=MGI=2143163|UniProtKB=Q3UMW7	MAP kinase-activated protein kinase 3	ISS	11335727	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	P00539	14-3-3	BOVIN|Gene=YWHAB|UniProtKB=P68250	14-3-3 protein beta/alpha	IGI	10407019	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00005	Angiogenesis	P00180	Dok-R	MOUSE|MGI=MGI=1332623|UniProtKB=O70469	Docking protein 2	ISS	12665569	PubMed	PTHR21258:SF14	DOCKING PROTEIN 2
P00018	EGF receptor signaling pathway	P00546	GAP	HUMAN|HGNC=9871|UniProtKB=P20936	Ras GTPase-activating protein 1	IGI	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00012	Cadherin signaling pathway	P00474	Wnt	CHICK|Ensembl=ENSGALG00000005123|UniProtKB=Q9DEB8	Protein Wnt	IDA	12549854	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00047	PDGF signaling pathway	P01168	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	7565716	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00020	FAS signaling pathway	P00615	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00199	JNKK1	MACMU|Ensembl=ENSMMUG00000019842|UniProtKB=F7FU91	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MACMU|Ensembl=ENSMMUG00000001661|UniProtKB=F7GR69	Uncharacterized protein	ISS	11554554	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	RCA	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00785	Cytochrome c	YEAST|SGD=S000005591|UniProtKB=P07143	Cytochrome c1, heme protein, mitochondrial	IDA	15163634	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00053	T cell activation	P01331	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00049	Parkinson disease	G01547	DAT	MACMU|Ensembl=ENSMMUG00000005198|UniProtKB=Q7JHP9	Transporter	IDA	15135042	PubMed	PTHR11616:SF38	SODIUM-DEPENDENT DOPAMINE TRANSPORTER
P00018	EGF receptor signaling pathway	P00547	PP2A	MOUSE|MGI=MGI=2388480|UniProtKB=Q6PD28	Protein Ppp2r5b	ISS	96161994	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01411	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P02738	De novo purine biosynthesis	P02902	ADP reductase	AQUAE|EnsemblGenome=aq_1505|UniProtKB=O67475	Ribonucleoside-diphosphate reductase subunit beta	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	MOUSE|MGI=MGI=1913316|UniProtKB=P61953	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	ISS	2122451	PubMed	PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P02738	De novo purine biosynthesis	P02902	ADP reductase	STRCO|Gene=CAB94611|UniProtKB=Q9K496	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	MOUSE|MGI=MGI=106028|UniProtKB=Q62159	Rho-related GTP-binding protein RhoC	IDA	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00016	Cytoskeletal regulation by Rho GTPase	P00513	Op18/stathmin	ORNAN|Ensembl=ENSOANG00000001728|UniProtKB=F7F009	Stathmin	ISS			PTHR10104:SF5	STATHMIN
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Ensembl=ENSPTRG00000016548|UniProtKB=H2QQC5	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	LEIMA|EnsemblGenome=LmjF.35.1010|UniProtKB=Q9NHE1	Casein kinase 1 isoform 2	IDA	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00021	FGF signaling pathway	P00627	ERK1-2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MACMU|Ensembl=ENSMMUG00000008537|UniProtKB=F6WBV7	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF147	MATRIX METALLOPROTEINASE-21
P00009	Axon guidance mediated by netrin	P00366	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04393	Ras Pathway	P04570	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04668	p53	BOVIN|Ensembl=ENSBTAG00000001069|UniProtKB=P67939	Cellular tumor antigen p53	TAS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	RAT|RGD=628837|UniProtKB=P60711	Actin, cytoplasmic 1	IC	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IDA	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00211	GSK3beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	11256888	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CAEEL|WormBase=WBGene00001680|UniProtKB=Q20636	Guanine nucleotide-binding protein subunit beta-2	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00057	Wnt signaling pathway	P01472	Histone deacetylase	RAT|RGD=1309799|UniProtKB=Q4QQW4	Histone deacetylase 1	ISS	12665570	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	MACMU|Ensembl=ENSMMUG00000006202|UniProtKB=F7HNP4	Excitatory amino acid transporter 1 isoform 1	ISS	96032356	PubMed	PTHR11958:SF24	EXCITATORY AMINO ACID TRANSPORTER 1
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04393	Ras Pathway	P04559	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	IDA	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00056	VEGF signaling pathway	P01407	Erk	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00774	Dynein complex	PANTR|Ensembl=ENSPTRG00000009604|UniProtKB=H2QDS5	Uncharacterized protein	ISS	9454836	PubMed	PTHR12442:SF7	DYNEIN INTERMEDIATE CHAIN 2, AXONEMAL
P00001	Adrenaline and noradrenaline biosynthesis	P00068	amine translocator	PANTR|Ensembl=ENSPTRG00000023683|UniProtKB=H2PZM1	Transporter	ISS	12719981	PubMed	PTHR11616:SF102	SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER SLC6A17
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	HUMAN|HGNC=5293|UniProtKB=P28223	5-hydroxytryptamine receptor 2A	IDA			PTHR24247:SF30	5-HYDROXYTRYPTAMINE RECEPTOR 2A
P00017	DNA replication	P00527	Histones	HUMAN|HGNC=33164|UniProtKB=Q6NXT2	Histone H3.3C	ISS	12413958	PubMed	PTHR11426:SF161	HISTONE H3.2-RELATED
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02729	Ascorbate degradation	P02849	L-xylulose kinase	CAEEL|WormBase=WBGene00011147|UniProtKB=P30646	Uncharacterized sugar kinase R08D7.7	ISS			PTHR10196:SF57	XYLULOSE KINASE
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CANLF|Ensembl=ENSCAFG00000013332|UniProtKB=F1PCQ4	Uncharacterized protein	ISS	15218628	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	DROME|FlyBase=FBgn0283499|UniProtKB=P09208	Insulin-like receptor	ISS	6754360	gi	PTHR24416:SF402	INSULIN RECEPTOR
P06587	Nicotine pharmacodynamics pathway	P06613	CHRNB2	MONDO|Ensembl=ENSMODG00000017165|UniProtKB=F6QDH4	Uncharacterized protein	ISS	22213672	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IGI	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IDA	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	DROME|FlyBase=FBgn0002413|UniProtKB=O76324	Discs overgrown protein kinase	IDA	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00029	Huntington disease	P00810	GAPDH	SCHMA|EnsemblGenome=Smp_056970|UniProtKB=G4V5I2	Glyceraldehyde-3-phosphate dehydrogenase	IPI			PTHR10836:SF52	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	XENTR|Xenbase=XB-GENE-483904|UniProtKB=F7ESG8	Receptor protein serine/threonine kinase (Fragment)	ISS	9395284	PubMed	PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P00005	Angiogenesis	P00223	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00467	alpha-catenin	XENTR|Xenbase=XB-GENE-479599|UniProtKB=F7DHT4	Uncharacterized protein	ISS	1768802	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P06959	CCKR signaling map	P07181	SRF	HUMAN|HGNC=11291|UniProtKB=P11831	Serum response factor	RCA	7697796	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P02781	Threonine biosynthesis	P03189	Aspartate kinase	YEAST|SGD=S000000854|UniProtKB=P10869	Aspartokinase	ISS			PTHR21499:SF3	ASPARTOKINASE
P04397	p53 pathway by glucose deprivation	P04641	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g242065|UniProtKB=A7S0V7	Predicted protein	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MOUSE|MGI=MGI=2136761|UniProtKB=Q8BKG4	Frizzled-10	ISS	8717036	PubMed	PTHR11309:SF86	FRIZZLED-10
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MACMU|Ensembl=ENSMMUG00000032222|UniProtKB=F7FW05	Uncharacterized protein	ISS	12441358	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00057	Wnt signaling pathway	P01472	Histone deacetylase	MONDO|Ensembl=ENSMODG00000017860|UniProtKB=F6YIM6	Histone deacetylase	ISS	10485845	PubMed	PTHR10625:SF171	HISTONE DEACETYLASE 2
P00010	B cell activation	P00383	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	MONDO|Ensembl=ENSMODG00000012761|UniProtKB=F6SJA3	Tyrosine-protein kinase receptor (Fragment)	ISS	11182407	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00047	PDGF signaling pathway	P01159	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00021	FGF signaling pathway	P00640	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	RCA	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00641	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04376	5HT4 type receptor mediated signaling pathway	P04427	5HT4 Receptor	MOUSE|MGI=MGI=109246|UniProtKB=P97288	5-hydroxytryptamine receptor 4	ISS	12441358	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IC	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00018	EGF receptor signaling pathway	P00551	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IGI	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02729	Ascorbate degradation	P02852	L-xylulose-5-phosphate-3-epimerase	ECOLI|EcoGene=EG12553|UniProtKB=P39362	Protein SgcE	ISS			PTHR11749:SF5	PROTEIN SGCE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	ANOGA|EnsemblGenome=AGAP010957|UniProtKB=Q7QGY7	AGAP010957-PA (Fragment)	ISS	7514101	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00030	Hypoxia response via HIF activation	P00823	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00640	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02779	Thiamin biosynthesis	P03170	Hydroxymethylpyrimidine phosphate kinase	ECOLI|EcoGene=EG14068|UniProtKB=P76422	Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase	ISS			PTHR20858:SF17	HYDROXYMETHYLPYRIMIDINE/PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED
P00025	Hedgehog signaling pathway	P00682	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	2372396	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00637	MKK4,7	HUMAN|HGNC=6844|UniProtKB=P45985	Dual specificity mitogen-activated protein kinase kinase 4	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00019	Endothelin signaling pathway	P00566	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	IC			PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00547	PP2A	MONDO|Ensembl=ENSMODG00000019001|UniProtKB=F7CP86	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P02772	Pyruvate metabolism	P03137	Citrate Lyase	FUSNN|EnsemblGenome=FN1379|UniProtKB=Q8RDW5	Citrate lyase beta chain	ISS			PTHR32308:SF0	CITRATE LYASE SUBUNIT BETA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05971	CREB	MONDO|Ensembl=ENSMODG00000006900|UniProtKB=F6PUU3	Uncharacterized protein	ISS			PTHR22952:SF97	CAMP-RESPONSIVE ELEMENT MODULATOR
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	RAT|RGD=3139|UniProtKB=Q29RW1	Myosin-4	ISS	10938134	PubMed	PTHR13140:SF657	MYOSIN-4
P00017	DNA replication	P00527	Histones	TRIAD|EnsemblGenome=TriadG24875|UniProtKB=B3RWE2	Histone H3	ISS	12413958	PubMed	PTHR11426:SF20	HISTONE H3-LIKE CENTROMERIC PROTEIN A
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MOUSE|MGI=MGI=87909|UniProtKB=P62737	Actin, aortic smooth muscle	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00015	Circadian clock system	P00505	Cry	RAT|RGD=735083|UniProtKB=Q32Q86	Cryptochrome-1	ISS	10428031	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00047	PDGF signaling pathway	P01161	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	TAS	10693759	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01408	Akt/PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	RAT|RGD=2735|UniProtKB=Q63273	Glutamate receptor ionotropic, kainate 5	ISS	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00005	Angiogenesis	P00234	Grb2	DANRE|ZFIN=ZDB-GENE-040426-1975|UniProtKB=Q6PC73	Growth factor receptor-bound protein 2	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	MOUSE|MGI=MGI=87940|UniProtKB=Q99MK8	Beta-adrenergic receptor kinase 1	IDA	8288567	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	RAT|RGD=2733|UniProtKB=P42260	Glutamate receptor ionotropic, kainate 2	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00021	FGF signaling pathway	P00627	ERK1-2	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00274	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00046	Oxidative stress response	P01126	ATF2	MONDO|Ensembl=ENSMODG00000009514|UniProtKB=F7EVK3	Uncharacterized protein	ISS	7875593	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MACMU|Ensembl=ENSMMUG00000014807|UniProtKB=F6W548	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT1G10210|UniProtKB=Q39021	Mitogen-activated protein kinase 1	IDA	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	YEAST|SGD=S000004689|UniProtKB=A2P2R3	Putative glutamine--fructose-6-phosphate aminotransferase [isomerizing]	ISS			PTHR10937:SF0	GH12731P-RELATED
P00019	Endothelin signaling pathway	P00574	Big ET1-4	MACMU|Ensembl=ENSMMUG00000007263|UniProtKB=F7FGG2	Preproendothelin-1	ISS	15117818	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00310	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00797	p53	PANTR|Ensembl=ENSPTRG00000008703|UniProtKB=H2QC53	Cellular tumor antigen p53	ISS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00010	B cell activation	P00398	IP3R	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	IGI	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	IC	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02723	Adenine and hypoxanthine salvage pathway	P02810	Adenine phosphoribosyl transferase	PANTR|Ensembl=ENSPTRG00000008466|UniProtKB=H2QBQ7	Adenine phosphoribosyltransferase	ISS			PTHR32315:SF3	ADENINE PHOSPHORIBOSYLTRANSFERASE
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02787	Vitamin B6 metabolism	P03229	Pyridoxal reductase	YEAST|SGD=S000006331|UniProtKB=Q06494	Putative pyridoxal reductase	RCA			PTHR43625:SF14	PYRIDOXAL REDUCTASE-RELATED
P02726	Aminobutyrate degradation	P02825	4-aminobutyrate aminotransferase	PANTR|Ensembl=ENSPTRG00000007746|UniProtKB=H2QAJ4	4-aminobutyrate aminotransferase	ISS	10989446	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	IGI	10851062	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	IDA	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00056	VEGF signaling pathway	P01411	Ras	CAEBR|Gene=CBG06092|UniProtKB=A8X0X5	Protein CBR-LET-60	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	HUMAN|HGNC=143|UniProtKB=P68032	Actin, alpha cardiac muscle 1	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	7925653	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TRIAD|EnsemblGenome=TriadG49626|UniProtKB=B3RKR4	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04393	Ras Pathway	P04546	GSK3	DICDI|dictyBase=DDB_G0272110|UniProtKB=P51136	Glycogen synthase kinase-3	IDA	7813009	PubMed	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00036	Interleukin signaling pathway	P00973	PKB	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01174	Rho	MONDO|Ensembl=ENSMODG00000010362|UniProtKB=F6TVC2	Uncharacterized protein	ISS	8649427	PubMed	PTHR12552:SF4	RHO GTPASE-ACTIVATING PROTEIN 26
P00005	Angiogenesis	P00236	PI3K	XENTR|Xenbase=XB-GENE-6067221|UniProtKB=F6Z0J4	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MOUSE|MGI=MGI=95684|UniProtKB=P97737	Growth/differentiation factor 10	TAS	9759503	PubMed	PTHR11848:SF145	GROWTH/DIFFERENTIATION FACTOR 10
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00047	PDGF signaling pathway	P01171	PLCgamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00017	DNA replication	P00538	RNase H	TRYB2|Gene=Tb927.7.4930|UniProtKB=Q57XA9	Ribonuclease H	ISS	97321566	PubMed	PTHR10642:SF0	RIBONUCLEASE H1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000001962|UniProtKB=F6V2H6	Uncharacterized protein	ISS	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00021	FGF signaling pathway	P00645	Rac	ENTHI|EnsemblGenome=EHI_070730|UniProtKB=C4M5T0	Rho family GTPase	ISS	97082968	PubMed	PTHR24072:SF117	RHO-RELATED PROTEIN RACC
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	RAT|RGD=620966|UniProtKB=Q62925	Mitogen-activated protein kinase kinase kinase 1	IGI	11730323	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00010	B cell activation	P00375	Calmodulin	TAKRU|Ensembl=ENSTRUG00000008685|UniProtKB=H2TXN3	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF326	CALMODULIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	ISS			PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00010	B cell activation	P00369	MEKK	CANLF|Ensembl=ENSCAFG00000012934|UniProtKB=F1P750	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00706	RGS-PX1	MACMU|Ensembl=ENSMMUG00000021915|UniProtKB=F6WJA8	Uncharacterized protein	ISS	11729322	PubMed	PTHR22775:SF30	SORTING NEXIN-13
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05731	GABA-B receptor II signaling	P05755	Gbeta	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04395	Vasopressin synthesis	P04593	Glycopeptide	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	IC	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00059	p53 pathway	G04703	Apaf	HUMAN|HGNC=576|UniProtKB=O14727	Apoptotic protease-activating factor 1	IDA	10364241	PubMed	PTHR22845:SF5	APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000006307|UniProtKB=H2SSM1	Uncharacterized protein	ISS			PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	TAS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00052	TGF-beta signaling pathway	P01284	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00029	Huntington disease	P00785	Cytochrome c	ARATH|TAIR=AT3G27240|UniProtKB=Q9LK29	Cytochrome c1 1, heme protein, mitochondrial	IDA	15163634	PubMed	PTHR10266:SF6	CYTOCHROME C1 1, HEME PROTEIN, MITOCHONDRIAL-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05912	Dopamine receptor mediated signaling pathway	P05960	VAT2	RAT|RGD=3694|UniProtKB=Q01827	Synaptic vesicular amine transporter	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=8156|UniProtKB=P35372	Mu-type opioid receptor	IDA	12093103	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	HUMAN|HGNC=6003|UniProtKB=Q9UHF4	Interleukin-20 receptor subunit alpha	TAS	11163236	PubMed	PTHR20859:SF21	INTERLEUKIN-20 RECEPTOR SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04392	P53 pathway feedback loops 1	P04539	p53	MACMU|Ensembl=ENSMMUG00000016569|UniProtKB=F6VXE7	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	RCA	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00029	Huntington disease	P00797	p53	DICDI|dictyBase=DDB_G0287855|UniProtKB=Q6UK63	Protein pirA	TAS			PTHR12195:SF0	CYTOPLASMIC FMR1-INTERACTING PROTEIN
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	ANOGA|EnsemblGenome=AGAP011152|UniProtKB=Q7QHE3	Phosphoinositide phospholipase C	ISS			PTHR10336:SF91	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00014	Cholesterol biosynthesis	P00491	Hydroxymethyl glutaryl CoA reductase	MONDO|Ensembl=ENSMODG00000002057|UniProtKB=F6V051	3-hydroxy-3-methylglutaryl coenzyme A reductase	ISS	Q29512	SPACC	PTHR10572:SF2	3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE
P00021	FGF signaling pathway	P00631	Grb2	MOUSE|MGI=MGI=1918770|UniProtKB=Q9CX99	GRB2-related adapter protein	ISS	8051109	PubMed	PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P00015	Circadian clock system	P00505	Cry	CANLF|Ensembl=ENSCAFG00000009379|UniProtKB=F1PNC9	Uncharacterized protein	ISS	11533252	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	HUMAN|HGNC=7882|UniProtKB=Q04721	Neurogenic locus notch homolog protein 2	IDA	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P05918	p38 MAPK pathway	P06031	p38alpha	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	RCA	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	CHICK|Ensembl=ENSGALG00000015835|UniProtKB=F1NZT2	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00004	Alzheimer disease-presenilin pathway	P00159	Nectin 1alpha intracellular fragment	CANLF|Ensembl=ENSCAFG00000012012|UniProtKB=F1PCB6	Uncharacterized protein	ISS	12376527	PubMed	PTHR23277:SF69	NECTIN-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02721	ATP synthesis	P02791	F1 alpha	ORYSJ|Gene=ATPA|UniProtKB=P0C522	ATP synthase subunit alpha, mitochondrial	TAS	8358823	PubMed	PTHR43089:SF2	ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00010	B cell activation	P00381	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01275	P38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	RAT|RGD=3238|UniProtKB=P01179	Oxytocin-neurophysin 1	ISS	6717565	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	MACMU|Ensembl=ENSMMUG00000017022|UniProtKB=F7HQZ9	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00030	Hypoxia response via HIF activation	P00814	P300	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	IDA	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00006	Apoptosis signaling pathway	P00318	PKCs	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00047	PDGF signaling pathway	P01168	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00107	kinesin	DROME|FlyBase=FBgn0010235|UniProtKB=P46824	Kinesin light chain	IDA	11740561	PubMed	PTHR19959:SF207	KINESIN LIGHT CHAIN
P06959	CCKR signaling map	P07150	beta-catenin	HUMAN|HGNC=2514|UniProtKB=P35222	Catenin beta-1	RCA	20150185	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00018	EGF receptor signaling pathway	P00548	RKIP	BOVIN|Ensembl=ENSBTAG00000018115|UniProtKB=P13696	Phosphatidylethanolamine-binding protein 1	ISS	92031654	PubMed	PTHR11362:SF28	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00034	Integrin signalling pathway	P00924	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	IPI	3449797	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P02738	De novo purine biosynthesis	P02905	Amidophosphoribosyl transferase	ANOGA|EnsemblGenome=AGAP000179|UniProtKB=Q7QEW3	Amidophosphoribosyltransferase	ISS			PTHR11907:SF18	AMIDOPHOSPHORIBOSYLTRANSFERASE
P04397	p53 pathway by glucose deprivation	P04636	S6K	RAT|RGD=1305144|UniProtKB=D4AE24	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00029	Huntington disease	P00780	Microtubule	PHYIT|EnsemblGenome=PITG_00156|UniProtKB=D0MT13	Beta-tubulin	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00560	Raf-1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01142	p90RSK	XENTR|Xenbase=XB-GENE-482409|UniProtKB=F6UK84	Uncharacterized protein (Fragment)	ISS	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CAEBR|Gene=CBG18256|UniProtKB=A8XS95	Protein CBR-ACT-5	ISS	10974003	PubMed	PTHR11937:SF352	ACTIN
P00036	Interleukin signaling pathway	P00983	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	RCA	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00057	Wnt signaling pathway	P01443	Phospholipase C	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	IDA	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00020	FAS signaling pathway	P00620	CytochromeC	CHLRE|EnsemblGenome=CHLREDRAFT_133395|UniProtKB=A8JIU5	Ubiquinol:cytochrome c oxidoreductase cytochrome c1	IGI	9027315	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00036	Interleukin signaling pathway	P00968	Ikk	MOUSE|MGI=MGI=1338071|UniProtKB=O88351	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00049	Parkinson disease	P01208	Hsp70	MACMU|Ensembl=ENSMMUG00000005875|UniProtKB=F6TLV2	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=1951|UniProtKB=P08172	Muscarinic acetylcholine receptor M2	IDA	91373358	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-990415-257|UniProtKB=O42376	Mitogen-activated protein kinase 12	IDA	11274345	PubMed	PTHR24055:SF339	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00006	Apoptosis signaling pathway	P00260	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05972	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	PUCGT|EnsemblGenome=PGTG_05488|UniProtKB=E3K4I1	Actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IDA	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	TAS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00029	Huntington disease	P00799	JNK-2	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000023046|UniProtKB=F6V829	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Ensembl=ENSCAFG00000010787|UniProtKB=E2R3W6	Uncharacterized protein	ISS	11861492	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00034	Integrin signalling pathway	P00933	Crk	MOUSE|MGI=MGI=104686|UniProtKB=P47941	Crk-like protein	ISS	8649368	PubMed	PTHR19969:SF9	CRK-LIKE PROTEIN
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000001044|UniProtKB=H2PZK0	Uncharacterized protein	ISS	8120095	PubMed	PTHR24026:SF32	CADHERIN EGF LAG SEVEN-PASS G-TYPE RECEPTOR 2
P00054	Toll receptor signaling pathway	P01351	TLR2,4,7	MOUSE|MGI=MGI=96824|UniProtKB=Q9QUK6	Toll-like receptor 4	ISS			PTHR44568:SF1	TOLL-LIKE RECEPTOR 4
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MOUSE|MGI=MGI=95817|UniProtKB=Q8BMF5	Glutamate receptor ionotropic, kainate 4	ISS	12941441	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00024	Glycolysis	P00679	Aldolase	CANLF|Ensembl=ENSCAFG00000018144|UniProtKB=F1PNI3	Uncharacterized protein	ISS	84261525	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00034	Integrin signalling pathway	P00941	Integrin alpha	BOVIN|Ensembl=ENSBTAG00000016566|UniProtKB=F1MMH2	Uncharacterized protein	ISS	3487386	PubMed	PTHR23220:SF69	INTEGRIN ALPHA-9
P00012	Cadherin signaling pathway	P00475	Frizzled	HUMAN|HGNC=4045|UniProtKB=O75084	Frizzled-7	IDA	11212302	PubMed	PTHR11309:SF31	FRIZZLED-7
P00059	p53 pathway	G04697	B99	PANTR|Ensembl=ENSPTRG00000014509|UniProtKB=H2QLW6	G-2 and S-phase expressed 1	ISS	20127556	gi	PTHR21584:SF10	G2 AND S PHASE-EXPRESSED PROTEIN 1
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00647	SHP2	MONDO|Ensembl=ENSMODG00000003120|UniProtKB=F6WVD2	Tyrosine-protein phosphatase non-receptor type	ISS	8096088	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00049	Parkinson disease	P01211	ERK	CANLF|Ensembl=ENSCAFG00000018202|UniProtKB=E2RPJ2	Mitogen-activated protein kinase	ISS	15085193	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MONDO|Ensembl=ENSMODG00000016895|UniProtKB=F6XII5	Uncharacterized protein	ISS	10391901	PubMed	PTHR15936:SF2	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-13
P00036	Interleukin signaling pathway	P00985	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	11256888	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	PRIPA|Gene=PPA19914|UniProtKB=H3FCG4	Uncharacterized protein	ISS			PTHR11937:SF359	SUBFAMILY NOT NAMED
P00045	Notch signaling pathway	P01120	NIcs	RAT|RGD=3187|UniProtKB=Q07008	Neurogenic locus notch homolog protein 1	IEP	1764995	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	ORYSJ|EnsemblGenome=OS01G0570500|UniProtKB=Q656Y0	Os01g0570500 protein	IDA	11437445	PubMed	PTHR11909:SF162	SUBFAMILY NOT NAMED
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00018	EGF receptor signaling pathway	P00545	JNK1-3	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05913	Enkephalin release	P05974	G-Protein (i)	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00019	Endothelin signaling pathway	P00566	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000009835|UniProtKB=F1MR37	Uncharacterized protein	ISS	18021322	PubMed	PTHR10037:SF137	VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1G
P00060	Ubiquitin proteasome pathway	P01494	19S proteasome	SCLS1|Gene=SS1G_11803|UniProtKB=A7F3F7	Uncharacterized protein	ISS			PTHR23073:SF8	26S PROTEASE REGULATORY SUBUNIT 6B
P00029	Huntington disease	P00805	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CHICK|Ensembl=ENSGALG00000009621|UniProtKB=P60706	Actin, cytoplasmic 1	ISS	11889139	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BOVIN|Gene=WNT16|UniProtKB=Q5E9U6	Protein Wnt-16	ISS	11266476	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P00008	Axon guidance mediated by Slit/Robo	P00348	Robo	BOVIN|Ensembl=ENSBTAG00000009851|UniProtKB=F1N739	Uncharacterized protein	ISS			PTHR44096:SF1	ROUNDABOUT HOMOLOG 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00023	General transcription regulation	P00668	TFIIB	METAC|EnsemblGenome=MA_0610|UniProtKB=Q8TT29	Transcription initiation factor IIB	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00006	Apoptosis signaling pathway	P00269	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00045	Notch signaling pathway	P01101	Su(H)	CIOIN|Ensembl=ENSCING00000000838|UniProtKB=O76808	Suppressor of hairless homolog	IGI	9808786	PubMed	PTHR10665:SF0	SUPPRESSOR OF HAIRLESS PROTEIN
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00021	FGF signaling pathway	P00644	p38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IGI	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P06587	Nicotine pharmacodynamics pathway	P06596	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	9763606	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00059	p53 pathway	P04616	PDK1/2	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	TAS	9094314	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MOUSE|MGI=MGI=99841|UniProtKB=P32304	5-hydroxytryptamine receptor 7	IDA	12441358	PubMed	PTHR24247:SF116	5-HYDROXYTRYPTAMINE RECEPTOR 7
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00057	Wnt signaling pathway	P01428	Frizzled	CANLF|Ensembl=ENSCAFG00000013159|UniProtKB=E2RAF3	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF79	FRIZZLED-9
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	NEUCR|EnsemblGenome=EFNCRG00000002605|UniProtKB=Q9UW15	Ribonucleoside-diphosphate reductase large chain	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P02761	Pantothenate biosynthesis	P03067	3-methyl-2-oxobutanoate hydroxymethyltransferase	STRCO|EnsemblGenome=CAB61702|UniProtKB=Q9RKS2	3-methyl-2-oxobutanoate hydroxymethyltransferase	ISS			PTHR20881:SF0	3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE
P00029	Huntington disease	P00796	Kainate receptor	MOUSE|MGI=MGI=95814|UniProtKB=Q60934	Glutamate receptor ionotropic, kainate 1	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MOUSE|MGI=MGI=99677|UniProtKB=O88444	Adenylate cyclase type 1	ISS	89298382	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00053	T cell activation	P01332	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IC	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00059	p53 pathway	P01486	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	TAS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P06664	Gonadotropin-releasing hormone receptor pathway	P06834	MAP3Ks	MOUSE|MGI=MGI=1346873|UniProtKB=Q61083	Mitogen-activated protein kinase kinase kinase 2	RCA	21735556	gi	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P06213	DPP signaling pathway	P06282	DPP full length	DROME|FlyBase=FBgn0000490|UniProtKB=P07713	Protein decapentaplegic	IEA	9759503	PubMed	PTHR11848:SF234	PROTEIN DECAPENTAPLEGIC
P06215	MYO signaling pathway	P06312	myoglianin	DROME|FlyBase=FBgn0026199|UniProtKB=Q9V4F4	LD29161p	IDA	16098524	PubMed	PTHR11848:SF176	LD29161P
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00078	Alpha1A/1B/1C	TAKRU|Ensembl=ENSTRUG00000012885|UniProtKB=H2U6T8	Uncharacterized protein (Fragment)	IC	6323229	PubMed	PTHR24248:SF0	ALPHA-2DA ADRENERGIC RECEPTOR-RELATED
P00049	Parkinson disease	P01219	SAPK	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	NAS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PHYIT|EnsemblGenome=PITG_15078|UniProtKB=D0NRL5	Actin-like protein	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	DROME|FlyBase=FBgn0051321|UniProtKB=Q8INF8	FI20128p1	ISS			PTHR23507:SF28	FI18259P1-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00749	RGS9	CANLF|Ensembl=ENSCAFG00000011148|UniProtKB=J9P1Y8	Uncharacterized protein	ISS	9459445	PubMed	PTHR10845:SF170	REGULATOR OF G-PROTEIN SIGNALING 9
P00054	Toll receptor signaling pathway	P01375	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00050	Plasminogen activating cascade	P01252	MMP-1	HUMAN|HGNC=7155|UniProtKB=P03956	Interstitial collagenase	IGI	12834808	PubMed	PTHR10201:SF151	INTERSTITIAL COLLAGENASE
P00001	Adrenaline and noradrenaline biosynthesis	P00067	MAO	PANTR|Ensembl=ENSPTRG00000021817|UniProtKB=H2QYH6	Amine oxidase [flavin-containing]	ISS	8602220	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	SCHPO|PomBase=SPAC23C11.11|UniProtKB=P40231	Casein kinase II subunit alpha	IDA	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	CANLF|Ensembl=ENSCAFG00000005204|UniProtKB=B6V8E6	Catenin beta-1	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00005	Angiogenesis	P00185	JAK1	MACMU|Ensembl=ENSMMUG00000018566|UniProtKB=F6YLX1	Tyrosine-protein kinase	ISS	9637709	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P02738	De novo purine biosynthesis	P02902	ADP reductase	CHLTR|EnsemblGenome=CT_828|UniProtKB=O84835	Ribonucleoside-diphosphate reductase subunit beta	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00021	FGF signaling pathway	P00643	Raf-1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IGI	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01151	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00977	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00021	FGF signaling pathway	P00633	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	ARATH|TAIR=AT3G59790|UniProtKB=Q9M1Z5	Mitogen-activated protein kinase 10	ISS			PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	CHICK|Ensembl=ENSGALG00000007509|UniProtKB=F1NM72	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00035	Interferon-gamma signaling pathway	P00961	STAT1	HUMAN|HGNC=11362|UniProtKB=P42224	Signal transducer and activator of transcription 1-alpha/beta	TAS	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	HUMAN|HGNC=1610|UniProtKB=P51686	C-C chemokine receptor type 9	ISS	6753462	gi	PTHR10489:SF664	C-C CHEMOKINE RECEPTOR TYPE 9
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	PANTR|Ensembl=ENSPTRG00000011042|UniProtKB=H2QGF5	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00006	Apoptosis signaling pathway	P00269	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00269	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	21071228	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04495	TSC1	PANTR|Ensembl=ENSPTRG00000021504|UniProtKB=H2QY35	Tuberous sclerosis 1	ISS	12820960	PubMed	PTHR15154:SF2	HAMARTIN
P00004	Alzheimer disease-presenilin pathway	P00114	actin	EMENI|EnsemblGenome=CADANIAG00007315|UniProtKB=P20359	Actin, gamma	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00019	Endothelin signaling pathway	P00572	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00025	Hedgehog signaling pathway	P00692	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04393	Ras Pathway	P04556	Raf	XENTR|Xenbase=XB-GENE-1014202|UniProtKB=F6V946	Uncharacterized protein (Fragment)	ISS	3043188	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00034	Integrin signalling pathway	P00940	Src	XENTR|Xenbase=XB-GENE-489820|UniProtKB=F7DXH6	Tyrosine-protein kinase	ISS	8054685	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DANRE|ZFIN=ZDB-GENE-040718-134|UniProtKB=Q6DH55	Guanine nucleotide binding protein (G protein), beta polypeptide 3, like	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00034	Integrin signalling pathway	P00951	Jnk	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00010	B cell activation	P00391	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00034	Integrin signalling pathway	P00951	Jnk	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IDA	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00023	General transcription regulation	P00660	RNA Polymerase II	ARATH|TAIR=AT3G22320|UniProtKB=O81098	DNA-directed RNA polymerases II and IV subunit 5A	ISS	11313498	PubMed	PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IDA	7925653	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	CHICK|Gene=CHRM4|UniProtKB=P17200	Muscarinic acetylcholine receptor M4	ISS	10069496	PubMed	PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	TAS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00049	Parkinson disease	P01211	ERK	CAEEL|WormBase=WBGene00015478|UniProtKB=Q11179	Putative serine/threonine-protein kinase C05D10.2	IDA	12787066	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00047	PDGF signaling pathway	P01162	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	BOVIN|Ensembl=ENSBTAG00000020756|UniProtKB=A6QLB8	GSK3A protein	ISS	11995474	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00049	Parkinson disease	P01230	Src kinase	MOUSE|MGI=MGI=103265|UniProtKB=Q922K9	Tyrosine-protein kinase FRK	IDA	11078745	PubMed	PTHR24418:SF296	TYROSINE-PROTEIN KINASE FRK
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	RCA	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00117	E-cadherin C-terminal fragment	MACMU|Ensembl=ENSMMUG00000010393|UniProtKB=F7D992	Uncharacterized protein	ISS	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	ANOGA|EnsemblGenome=AGAP001506|UniProtKB=Q7PXP3	AGAP001506-PA	IC			PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	IPI	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=2446084|UniProtKB=Q8R5M2	Protein Wnt-9a	TAS	8717036	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00193	SOS-1	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IDA	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	IC	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CAEEL|WormBase=WBGene00004037|UniProtKB=Q9XWB7	Phosphoinositide phospholipase C	ISS			PTHR10336:SF9	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	TAKRU|Ensembl=ENSTRUG00000015213|UniProtKB=H2UPJ1	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF356	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=1351343|UniProtKB=Q5NCH9	Metabotropic glutamate receptor 6	ISS	12351712	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	YEAST|SGD=S000005982|UniProtKB=P54115	Magnesium-activated aldehyde dehydrogenase, cytosolic	IC			PTHR11699:SF268	MAGNESIUM-ACTIVATED ALDEHYDE DEHYDROGENASE, CYTOSOLIC-RELATED
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00226	Delta/Serrate	MONDO|Ensembl=ENSMODG00000004910|UniProtKB=F7C1Q4	Delta-like protein	ISS	12826675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00048	PI3 kinase pathway	P01189	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00006	Apoptosis signaling pathway	P00307	ELF2alpha	CHICK|Ensembl=ENSGALG00000009565|UniProtKB=Q5ZLX2	Eukaryotic translation initiation factor 2 subunit 1	ISS			PTHR10602:SF0	EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1
P00020	FAS signaling pathway	P00615	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00021	FGF signaling pathway	P00628	JNK1-3	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CAEBR|Gene=CBG18112|UniProtKB=A8XT20	Protein CBR-GLR-1	ISS	10331083	PubMed	PTHR18966:SF297	GLUTAMATE RECEPTOR 1
P00012	Cadherin signaling pathway	P00470	F-actin	CANLF|Ensembl=ENSCAFG00000016020|UniProtKB=O18840	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MOUSE|MGI=MGI=1346876|UniProtKB=O35099	Mitogen-activated protein kinase kinase kinase 5	ISS	12566458	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00059	p53 pathway	G04705	p48	PANTR|Ensembl=ENSPTRG00000003558|UniProtKB=H2Q3I6	Damage-specific DNA binding protein 2, 48kDa	ISS	14560002	PubMed	PTHR15169:SF2	DNA DAMAGE-BINDING PROTEIN 2
P00048	PI3 kinase pathway	P01188	Gbetagamma	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00034	Integrin signalling pathway	P00931	Integrin beta	HUMAN|Ensembl=ENSG00000259753|UniProtKB=H3BM21	Integrin beta (Fragment)	IDA	484963	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PANTR|Ensembl=ENSPTRG00000009762|UniProtKB=H2QE24	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	XENTR|Xenbase=XB-GENE-490883|UniProtKB=Q6NVA9	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P02746	Heme biosynthesis	P02979	porphobilinogen synthase	BRADU|EnsemblGenome=BAC50302|UniProtKB=P45622	Delta-aminolevulinic acid dehydratase	ISS			PTHR11458:SF0	DELTA-AMINOLEVULINIC ACID DEHYDRATASE
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_206575|UniProtKB=E9FUX0	Guanine nucleotide binding protein, beta subunit	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	HUMAN|HGNC=365|UniProtKB=Q9Y6K8	Adenylate kinase isoenzyme 5	ISS			PTHR23359:SF79	ADENYLATE KINASE ISOENZYME 5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	RAT|RGD=1303282|UniProtKB=Q6MG89	Notch homolog 4, [Drosophila]	ISS	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P00011	Blood coagulation	P00429	PN2	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	ISS	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00012	Cadherin signaling pathway	P00474	Wnt	DANRE|ZFIN=ZDB-GENE-980526-87|UniProtKB=Q92050	Protein Wnt-5b	IDA	11266476	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9441|UniProtKB=P51817	cAMP-dependent protein kinase catalytic subunit PRKX	IC	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P05916	Opioid prodynorphin pathway	P06002	G-protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IC	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	BOVIN|Ensembl=ENSBTAG00000035084|UniProtKB=F1MLG5	Uncharacterized protein	ISS	12549854	PubMed	PTHR11309:SF22	FRIZZLED-3
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=1928330|UniProtKB=Q6PFX6	Cadherin-24	ISS	8120095	PubMed	PTHR24027:SF272	CADHERIN-24
P06211	BMP/activin signaling pathway-drosophila	P06245	R-Smad	DROME|FlyBase=FBgn0025800|UniProtKB=O96660	Mothers against decapentaplegic homolog	RCA			PTHR13703:SF25	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05943	GRK2	CANLF|Ensembl=ENSCAFG00000011733|UniProtKB=E2R5J6	Protein-serine/threonine kinase	ISS	10852916	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IDA	3045562	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P05918	p38 MAPK pathway	P06026	MEKK4	RAT|RGD=1311192|UniProtKB=A0A0G2K3R1	Protein Map3k4	ISS	9079650	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P04395	Vasopressin synthesis	P04596	Endo Peptidase	GLOVI|Gene=BAC88622|UniProtKB=Q7NMT4	Prolyl endopeptidase	IC	9695945	PubMed	PTHR42881:SF2	PROLYL ENDOPEPTIDASE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	RAT|RGD=2732|UniProtKB=P22756	Glutamate receptor ionotropic, kainate 1	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00034	Integrin signalling pathway	P00941	Integrin alpha	PANTR|Ensembl=ENSPTRG00000002321|UniProtKB=H2Q1N7	Uncharacterized protein	ISS	3487386	PubMed	PTHR23220:SF5	INTEGRIN ALPHA-8
P00021	FGF signaling pathway	P00644	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00219	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00025	Hedgehog signaling pathway	P00682	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00019	Endothelin signaling pathway	P00586	Gq	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02728	Arginine biosynthesis	P02840	Argininosuccinate synthase	PANTR|Ensembl=ENSPTRG00000021473|UniProtKB=H2QY18	Argininosuccinate synthetase 1	ISS			PTHR11587:SF2	ARGININOSUCCINATE SYNTHASE
P00021	FGF signaling pathway	P00645	Rac	DROME|FlyBase=FBgn0010333|UniProtKB=P40792	Ras-related protein Rac1	IGI	95047333	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00029	Huntington disease	P00807	Actin	MACMU|Ensembl=ENSMMUG00000007027|UniProtKB=F7F210	Alpha-cardiac actin	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	HUMAN|HGNC=1442|UniProtKB=P62158	Calmodulin	IDA	7514101	PubMed	PTHR23050:SF311	CALMODULIN
P04393	Ras Pathway	P04552	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	TAS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00056	VEGF signaling pathway	P01425	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02743	Formyltetrahydroformate biosynthesis	P02952	Methylene tetrahydrofolate dehydrogenase	STRCO|EnsemblGenome=CAB97427|UniProtKB=Q9K3J6	Bifunctional protein FolD	ISS			PTHR10025:SF46	BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, MITOCHONDRIAL
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	RAT|RGD=70989|UniProtKB=Q78EA7	Bone morphogenetic protein receptor type-1A	IDA			PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	DANRE|ZFIN=ZDB-GENE-070524-2|UniProtKB=B6E506	Dopamine receptor D1	ISS	11861492	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00012	Cadherin signaling pathway	P00462	Casein kinase II	CAEBR|Gene=CBG12820|UniProtKB=A8XFP5	Protein CBR-KIN-3	ISS	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	CANLF|Ensembl=ENSCAFG00000000332|UniProtKB=F1P8E3	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00016	Cytoskeletal regulation by Rho GTPase	P00521	Profilin	ENTHI|EnsemblGenome=EHI_176140|UniProtKB=C4MB21	Profilin	ISS			PTHR11604:SF19	PROFILIN-1
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	XENTR|Xenbase=XB-GENE-491571|UniProtKB=F6WW07	Uncharacterized protein (Fragment)	ISS	12473693	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01065	VAChT	ANOGA|EnsemblGenome=AGAP002369|UniProtKB=Q7PR83	AGAP002369-PA	ISS	7938002	PubMed	PTHR23506:SF13	VESICULAR ACETYLCHOLINE TRANSPORTER
P00049	Parkinson disease	P01219	SAPK	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	NAS	12040174	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00005	Angiogenesis	P00219	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DROME|FlyBase=FBgn0013343|UniProtKB=Q24547	Syntaxin-1A	IC			PTHR19957:SF41	SYNTAXIN-1A
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IDA	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MACMU|Ensembl=ENSMMUG00000009341|UniProtKB=F6UA54	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P06959	CCKR signaling map	P07210	BAD	HUMAN|HGNC=936|UniProtKB=Q92934	Bcl2-associated agonist of cell death	RCA	18565785	PubMed	PTHR28540:SF1	BCL2-ASSOCIATED AGONIST OF CELL DEATH
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00976	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IDA	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IDA	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	IDA	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00010	B cell activation	P00370	NFkappaB	MOUSE|MGI=MGI=1099800|UniProtKB=Q9WTK5	Nuclear factor NF-kappa-B p100 subunit	IDA	12574369	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00021	FGF signaling pathway	P00624	14-3-3	SCHMA|EnsemblGenome=Smp_002410|UniProtKB=Q95W36	14-3-3 epsilon 2	IGI	12062487	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	HUMAN|HGNC=1959|UniProtKB=P30532	Neuronal acetylcholine receptor subunit alpha-5	ISS	85270494	PubMed	PTHR18945:SF76	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5
P00053	T cell activation	P01322	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	TAS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00044	Nicotinic acetylcholine receptor signaling pathway	P01093	AChE	HUMAN|HGNC=108|UniProtKB=P22303	Acetylcholinesterase	IC			PTHR11559:SF356	ACETYLCHOLINESTERASE
P00019	Endothelin signaling pathway	P00572	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	IC	91056091	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00046	Oxidative stress response	P01121	MKK3/6	CANLF|Ensembl=ENSCAFG00000018530|UniProtKB=F1PXD3	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00056	VEGF signaling pathway	P01425	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MOUSE|MGI=MGI=2150393|UniProtKB=Q91ZU9	Glutamate receptor ionotropic, NMDA 3B	ISS	14698601	PubMed	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P00012	Cadherin signaling pathway	P00471	Cadherin	MONDO|Ensembl=ENSMODG00000004905|UniProtKB=F7C1R7	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF84	CADHERIN-20
P02772	Pyruvate metabolism	P03140	Pyruvate Carboxylase	EMENI|EnsemblGenome=CADANIAG00005990|UniProtKB=Q5B4R8	Pyruvate carboxylase	ISS	12044690	gi	PTHR43778:SF2	PYRUVATE CARBOXYLASE, MITOCHONDRIAL
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	9332390	PubMed	PTHR10202:SF13	PRESENILIN-2
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	ISS	96320556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P06959	CCKR signaling map	P07166	MAPK1	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	RCA	9230117	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00029	Huntington disease	P00790	beta-Tubulin	MONDO|Ensembl=ENSMODG00000023805|UniProtKB=F7F082	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P02752	Mannose metabolism	P03018	Mannose 1-P guanylyl transferase	MOUSE|MGI=MGI=2660880|UniProtKB=Q8BTZ7	Mannose-1-phosphate guanyltransferase beta	IDA	11082198	PubMed	PTHR22572:SF15	MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE BETA
P00010	B cell activation	P00383	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00047	PDGF signaling pathway	P01161	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00048	PI3 kinase pathway	P01206	14-3-3	MONDO|Ensembl=ENSMODG00000006158|UniProtKB=F7BS95	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	ARATH|TAIR=AT5G47080|UniProtKB=P40228	Casein kinase II subunit beta	IDA	10617630	PubMed	PTHR11740:SF15	CASEIN KINASE II SUBUNIT BETA-RELATED
P02785	Valine biosynthesis	P03216	Acetolactate synthase	ARATH|TAIR=AT3G48560|UniProtKB=P17597	Acetolactate synthase, chloroplastic	ISS			PTHR18968:SF112	ACETOLACTATE SYNTHASE, CHLOROPLASTIC
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CANLF|Ensembl=ENSCAFG00000028654|UniProtKB=J9P702	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	RCA			PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00029	Huntington disease	P00790	beta-Tubulin	NEUCR|EnsemblGenome=EFNCRG00000003612|UniProtKB=P05220	Tubulin beta chain	TAS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	TAS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05730	Endogenous cannabinoid signaling	P05751	Galpha	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01140	ELK	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	3183861	gi	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01182	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00053	T cell activation	P01300	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	RCA	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=3972|UniProtKB=Q12841	Follistatin-related protein 1	ISS	8717036	PubMed	PTHR10913:SF13	FOLLISTATIN-RELATED PROTEIN 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000014976|UniProtKB=H2R892	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00036	Interleukin signaling pathway	P00965	ERK	RAT|RGD=628675|UniProtKB=Q9Z2A6	Mitogen-activated protein kinase 15	TAS	9891064	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2051|UniProtKB=P28647	Adenosine receptor A3	ISS	12515326	PubMed	PTHR24246:SF2	ADENOSINE RECEPTOR A3
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PHANO|Gene=SNOG_06790|UniProtKB=P41799	Tubulin beta chain	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	CANAL|CGD=CAL0001034|UniProtKB=Q59W67	S-adenosylmethionine synthase	ISS			PTHR11964:SF1	S-ADENOSYLMETHIONINE SYNTHASE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00049	Parkinson disease	P01212	p38 MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	HUMAN|HGNC=20772|UniProtKB=Q13509	Tubulin beta-3 chain	ISS	12932731	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	CHICK|Ensembl=ENSGALG00000007509|UniProtKB=F1NM72	Uncharacterized protein	ISS	87005246	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00019	Endothelin signaling pathway	P00568	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00053	T cell activation	P01311	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	BOVIN|Ensembl=ENSBTAG00000006495|UniProtKB=P11017	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00020	FAS signaling pathway	P00615	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00786	ARF	ARATH|TAIR=AT1G10630|UniProtKB=Q6ID97	ADP-ribosylation factor A1F	IPI	12932731	PubMed	PTHR11711:SF210	ADP-RIBOSYLATION FACTOR 2-A-RELATED
P00018	EGF receptor signaling pathway	P00558	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00046	Oxidative stress response	P01129	JNK1/2	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	15528206	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00054	Toll receptor signaling pathway	P01369	MKK1	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05957	K+ channel	HUMAN|HGNC=6283|UniProtKB=Q9NPC2	Potassium channel subfamily K member 9	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00034	Integrin signalling pathway	P00944	Actin	DICDI|dictyBase=DDB_G0275023|UniProtKB=Q553U6	Putative actin-22	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P05731	GABA-B receptor II signaling	P05754	Ggamma	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01452	NFAT	HUMAN|HGNC=7778|UniProtKB=Q14934	Nuclear factor of activated T-cells, cytoplasmic 4	IDA	12787506	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	IDA	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P02728	Arginine biosynthesis	P02840	Argininosuccinate synthase	METAC|EnsemblGenome=MA_2142|UniProtKB=Q8TNY5	Argininosuccinate synthase	ISS			PTHR11587:SF2	ARGININOSUCCINATE SYNTHASE
P05913	Enkephalin release	P05975	GPCR (s)	MOUSE|MGI=MGI=97441|UniProtKB=P42866	Mu-type opioid receptor	ISS	12093103	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	HUMAN|HGNC=6857|UniProtKB=Q99683	Mitogen-activated protein kinase kinase kinase 5	IGI	12968034	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	IC	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P05734	Synaptic vesicle trafficking	P05775	Synapsin	CAEEL|WormBase=WBGene00004913|UniProtKB=Q8MXU3	SyNapsiN	RCA			PTHR10841:SF17	SYNAPSIN
P00048	PI3 kinase pathway	P01188	Gbetagamma	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01465	Ggamma	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00029	Huntington disease	P00797	p53	CANLF|Ensembl=ENSCAFG00000013961|UniProtKB=F1PL57	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00776	c-Jun	XENTR|Xenbase=XB-GENE-482228|UniProtKB=F6RYL1	Uncharacterized protein	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00910	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	4504111	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P02776	Serine glycine biosynthesis	P03159	Phosphoserine phosphatase	MOUSE|MGI=MGI=97788|UniProtKB=Q99LS3	Phosphoserine phosphatase	ISS			PTHR43344:SF2	PHOSPHOSERINE PHOSPHATASE
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-070112-342|UniProtKB=A1L271	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	BOVIN|Gene=ADRBK2|UniProtKB=P26818	Beta-adrenergic receptor kinase 2	RCA			PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P00018	EGF receptor signaling pathway	P00547	PP2A	BOVIN|Ensembl=ENSBTAG00000000469|UniProtKB=P67774	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04569	Cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	HUMAN|HGNC=4584|UniProtKB=Q05586	Glutamate receptor ionotropic, NMDA 1	IC	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00056	VEGF signaling pathway	P01404	SPK	BOVIN|Ensembl=ENSBTAG00000009872|UniProtKB=E1BJM1	Uncharacterized protein	ISS			PTHR12358:SF40	SPHINGOSINE KINASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00057	Wnt signaling pathway	P01432	Beta-Catenin	MACMU|Ensembl=ENSMMUG00000014627|UniProtKB=F7GNE4	Catenin beta-1	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P04393	Ras Pathway	P04572	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00030	Hypoxia response via HIF activation	P00825	Thioredoxin	MOUSE|MGI=MGI=98874|UniProtKB=P10639	Thioredoxin	ISS	12115731	PubMed	PTHR10438:SF18	THIOREDOXIN
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00019	Endothelin signaling pathway	P00566	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DROME|FlyBase=FBgn0000043|UniProtKB=P02572	Actin-42A	ISS	10974003	PubMed	PTHR11937:SF369	ACTIN-42A
P00059	p53 pathway	P04634	Cdc2	CANLF|Ensembl=ENSCAFG00000012904|UniProtKB=E2RGJ9	Uncharacterized protein	ISS			PTHR24056:SF334	CYCLIN-DEPENDENT KINASE 1
P04393	Ras Pathway	P04546	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02759	Pyridoxal-5-phosphate biosynthesis	P03062	1-Deoxyxylulose-5-phosphate synthase	ECOLI|EcoGene=EG13612|UniProtKB=P77488	1-deoxy-D-xylulose-5-phosphate synthase	ISS			PTHR43322:SF6	1-DEOXY-D-XYLULOSE-5-PHOSPHATE SYNTHASE
P00049	Parkinson disease	P01219	SAPK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05918	p38 MAPK pathway	P06021	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	12676940	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	HUMAN|HGNC=16767|UniProtKB=Q8TCU5	Glutamate receptor ionotropic, NMDA 3A	IC	14698601	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00047	PDGF signaling pathway	P01154	Ras	DICPU|Gene=DICPUDRAFT_91367|UniProtKB=F0ZB76	Putative uncharacterized protein rasD	ISS	85024887	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00021	FGF signaling pathway	P00645	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	10891487	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00053	T cell activation	P01300	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00056	VEGF signaling pathway	P01407	Erk	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01171	PLCgamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04395	Vasopressin synthesis	P04594	Neurophysin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P02733	Carnitine metabolism	P02866	Carnitine dehydratase	PSEAE|EnsemblGenome=PA3592|UniProtKB=Q9HY34	Uncharacterized protein	ISS			PTHR43949:SF7	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	G01548	I-SMAD	HUMAN|HGNC=6773|UniProtKB=O15105	Mothers against decapentaplegic homolog 7	IGI	9335505	PubMed	PTHR13703:SF27	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 7
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00049	Parkinson disease	P01234	GRK	HUMAN|HGNC=289|UniProtKB=P25098	Beta-adrenergic receptor kinase 1	IDA	10852916	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	CAEEL|WormBase=WBGene00009035|UniProtKB=Q19699	Glutamine-Fructose 6-phosphate AminoTransferase homolog	ISS			PTHR10937:SF0	GH12731P-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00018	EGF receptor signaling pathway	P00546	GAP	NEUCR|EnsemblGenome=EFNCRG00000001789|UniProtKB=Q7RWZ8	Uncharacterized protein	ISS	18307455	gi	PTHR10194:SF60	NEUROFIBROMIN
P00005	Angiogenesis	P00223	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00190	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	CANLF|Ensembl=ENSCAFG00000003604|UniProtKB=E2R5G6	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF245	RAS-RELATED PROTEIN R-RAS
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	RAT|RGD=628662|UniProtKB=Q8K4D8	Aldehyde dehydrogenase family 1 member A3	IC			PTHR11699:SF209	ALDEHYDE DEHYDROGENASE FAMILY 1 MEMBER A3
P00041	Metabotropic glutamate receptor group I pathway	P01062	mGluR1	CANLF|Ensembl=ENSCAFG00000004381|UniProtKB=J9JH96	Uncharacterized protein	ISS			PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	IC	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00034	Integrin signalling pathway	P00938	Cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	176910	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000022548|UniProtKB=F6Y9J9	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01411	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00012	Cadherin signaling pathway	P00474	Wnt	PANTR|Ensembl=ENSPTRG00000012931|UniProtKB=H2QJF8	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00056	VEGF signaling pathway	P01407	Erk	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04407	K+ channel	RAT|RGD=61997|UniProtKB=O54912	Potassium channel subfamily K member 3	ISS	11875121	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P02738	De novo purine biosynthesis	P02909	GDP reductase	ECOLI|EcoGene=EG20257|UniProtKB=P39452	Ribonucleoside-diphosphate reductase 2 subunit alpha	ISS			PTHR11573:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MONDO|Ensembl=ENSMODG00000016960|UniProtKB=F6V5G0	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	DROME|FlyBase=FBgn0019947|UniProtKB=O02194	Presenilin homolog	TAS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01300	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_115566|UniProtKB=C3XYC8	Putative uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00047	PDGF signaling pathway	P01159	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00053	T cell activation	P01323	I kappa B	MOUSE|MGI=MGI=104741|UniProtKB=Q9Z1E3	NF-kappa-B inhibitor alpha	ISS	14665694	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MONDO|Ensembl=ENSMODG00000024440|UniProtKB=F7DJJ2	Muscarinic acetylcholine receptor	ISS	12181435	PubMed	PTHR44672:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	P06785	ELK1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	RCA	14670631	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Gene=ACTA2|UniProtKB=P08023	Actin, aortic smooth muscle	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	AQUAE|EnsemblGenome=aq_1172|UniProtKB=O67233	Carbamoyl-phosphate synthase large chain, C-terminal section	ISS			PTHR11405:SF5	CAD PROTEIN
P00048	PI3 kinase pathway	P01204	GPCR	RAT|RGD=3435|UniProtKB=P34980	Prostaglandin E2 receptor EP3 subtype	IC	14607241	PubMed	PTHR11866:SF10	PROSTAGLANDIN E2 RECEPTOR EP3 SUBTYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	10395542	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DROME|FlyBase=FBgn0004921|UniProtKB=P38040	Guanine nucleotide-binding protein subunit gamma-1	IC			PTHR13809:SF3	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04407	K+ channel	BOVIN|Ensembl=ENSBTAG00000018193|UniProtKB=E1BHX8	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00057	Wnt signaling pathway	P01428	Frizzled	CANLF|Gene=FZD6|UniProtKB=Q8WMU5	Frizzled-6	IDA	11212302	PubMed	PTHR11309:SF75	FRIZZLED-6
P00034	Integrin signalling pathway	P00922	Collagen	MOUSE|MGI=MGI=1341272|UniProtKB=Q80X19	Collagen alpha-1(XIV) chain	ISS	10778855	PubMed	PTHR44557:SF1	COLLAGEN ALPHA-1 XIV  CHAIN
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04393	Ras Pathway	P04572	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01465	Ggamma	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00052	TGF-beta signaling pathway	P01275	P38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00056	VEGF signaling pathway	P01417	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00008	Axon guidance mediated by Slit/Robo	P00344	Netrin	HUMAN|HGNC=8030|UniProtKB=O00634	Netrin-3	ISS			PTHR10574:SF292	NETRIN-3
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05913	Enkephalin release	P05974	G-Protein (i)	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	MONDO|Ensembl=ENSMODG00000016287|UniProtKB=F7AU53	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF63	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-2
P04393	Ras Pathway	P04559	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	IDA	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	CANLF|Ensembl=ENSCAFG00000002598|UniProtKB=F6XUY6	Fructose-bisphosphate aldolase	ISS	8086469	PubMed	PTHR11627:SF2	FRUCTOSE-BISPHOSPHATE ALDOLASE B
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00046	Oxidative stress response	P01126	ATF2	MONDO|Ensembl=ENSMODG00000009514|UniProtKB=F7EVK3	Uncharacterized protein	ISS	15218628	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00006	Apoptosis signaling pathway	P00321	HSP70	HUMAN|HGNC=5241|UniProtKB=P11142	Heat shock cognate 71 kDa protein	ISS	12150907	PubMed	PTHR19375:SF239	HEAT SHOCK COGNATE 71 KDA PROTEIN
P00034	Integrin signalling pathway	P00907	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	IDA	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04393	Ras Pathway	P04570	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	PSEAE|EnsemblGenome=PA5312|UniProtKB=Q9HTP2	Probable aldehyde dehydrogenase	IC			PTHR11699:SF211	ALDEHYDE DEHYDROGENASE 5, MITOCHONDRIAL
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=2136739|UniProtKB=Q91XZ5	Protein Pcdhb5	IDA	8120095	PubMed	PTHR24028:SF55	PROTOCADHERIN BETA-4
P00047	PDGF signaling pathway	P01171	PLCgamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00052	TGF-beta signaling pathway	P01284	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00006	Apoptosis signaling pathway	P00321	HSP70	HUMAN|HGNC=5233|UniProtKB=P0DMV9	Heat shock 70 kDa protein 1B	ISS	12150907	PubMed	PTHR19375:SF223	HEAT SHOCK 70 KDA PROTEIN 1A-RELATED
P00057	Wnt signaling pathway	P01443	Phospholipase C	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00034	Integrin signalling pathway	P00924	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	BOVIN|Ensembl=ENSBTAG00000001856|UniProtKB=Q3T0Q3	DNA-directed RNA polymerase II subunit RPB3	ISS	2187864	PubMed	PTHR11800:SF2	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DROME|FlyBase=FBgn0261854|UniProtKB=A1Z9X0	Atypical protein kinase C	ISS	3755548	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00048	PI3 kinase pathway	P01202	p85	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00543	ERK1-2	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00047	PDGF signaling pathway	P01154	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00034	Integrin signalling pathway	P00906	Rap1	BOVIN|Ensembl=ENSBTAG00000016961|UniProtKB=A4IFU2	RAP2B protein	ISS	8576107	PubMed	PTHR24070:SF194	RAS-RELATED PROTEIN RAP-2B
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00572	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00054	Toll receptor signaling pathway	P01346	TLR	RAT|RGD=3870|UniProtKB=Q9QX05	Toll-like receptor 4	ISS			PTHR44568:SF1	TOLL-LIKE RECEPTOR 4
P00034	Integrin signalling pathway	P00925	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IDA	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00925	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00010	B cell activation	P00379	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00009	Axon guidance mediated by netrin	P00363	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	BOVIN|Ensembl=ENSBTAG00000014583|UniProtKB=P62157	Calmodulin	ISS			PTHR23050:SF335	CALMODULIN, STRIATED MUSCLE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	MONDO|Ensembl=ENSMODG00000007323|UniProtKB=F7EFD0	Uncharacterized protein	ISS	8576107	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00057	Wnt signaling pathway	P01435	SWI/SNF	CAEEL|WormBase=WBGene00002169|UniProtKB=P41877	Chromatin-remodeling complex ATPase chain isw-1	IDA	11532957	PubMed	PTHR10799:SF879	CHROMATIN-REMODELING COMPLEX ATPASE CHAIN ISWI
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	RAT|RGD=3238|UniProtKB=P01179	Oxytocin-neurophysin 1	ISS	9756087	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P06959	CCKR signaling map	P07068	PKCeta	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	RCA	12058027	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	NEUCR|EnsemblGenome=EFNCRG00000000147|UniProtKB=Q7RYT1	Aldehyde dehydrogenase	IC			PTHR43720:SF1	ALDEHYDE DEHYDROGENASE  NAD P +  1-RELATED
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=4598|UniProtKB=O15303	Metabotropic glutamate receptor 6	IDA	9407094	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00005	Angiogenesis	P00206	Wnt	PANTR|Ensembl=ENSPTRG00000004892|UniProtKB=H2Q5U3	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	RAT|RGD=70958|UniProtKB=P19492	Glutamate receptor 3	ISS	10331083	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00476	Yes	MACMU|Ensembl=ENSMMUG00000014149|UniProtKB=F7BV42	Tyrosine-protein kinase	ISS			PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P04393	Ras Pathway	P04559	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00049	Parkinson disease	P01227	20S proteasome	HUMAN|HGNC=22985|UniProtKB=Q8TAA3	Proteasome subunit alpha type-7-like	ISS	12859888	PubMed	PTHR11599:SF47	PROTEASOME SUBUNIT ALPHA TYPE-7-LIKE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02778	Sulfate assimilation	P03167	Sulfate adenylyltransferase	CANLF|Ensembl=ENSCAFG00000011167|UniProtKB=E2QZ13	Uncharacterized protein	ISS			PTHR11055:SF17	BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE 1
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	CAEEL|WormBase=WBGene00000392|UniProtKB=Q20628	CytiDine Deaminase	ISS			PTHR11644:SF2	CYTIDINE DEAMINASE
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	BOVIN|Ensembl=ENSBTAG00000035370|UniProtKB=Q32LB1	TATA box-binding protein-like protein 1	ISS	600075	OMIM	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MONDO|Ensembl=ENSMODG00000011628|UniProtKB=F6U132	Actin-related protein 2/3 complex subunit 3	ISS	12473693	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	TAS	8920915	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00036	Interleukin signaling pathway	P00997	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	10982827	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00025	Hedgehog signaling pathway	P00699	Su(fu)	MONDO|Ensembl=ENSMODG00000011242|UniProtKB=F6RMT7	Uncharacterized protein (Fragment)	ISS	10920228	PubMed	PTHR10928:SF2	SUPPRESSOR OF FUSED HOMOLOG
P04397	p53 pathway by glucose deprivation	P04641	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05961	DOPA decarb.	DANRE|ZFIN=ZDB-GENE-040426-2656|UniProtKB=Q7SZR0	Ddc protein	ISS	90339966	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P02759	Pyridoxal-5-phosphate biosynthesis	P03062	1-Deoxyxylulose-5-phosphate synthase	STRCO|EnsemblGenome=CAB39701|UniProtKB=Q9X7W3	1-deoxy-D-xylulose-5-phosphate synthase 1	ISS			PTHR43322:SF6	1-DEOXY-D-XYLULOSE-5-PHOSPHATE SYNTHASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00566	ERK	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01284	JNK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04393	Ras Pathway	P04558	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00007	Axon guidance mediated by semaphorins	P00331	PAK	MACMU|Ensembl=ENSMMUG00000001387|UniProtKB=F7D0B4	Uncharacterized protein	ISS	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	TAKRU|Ensembl=ENSTRUG00000007253|UniProtKB=H2SZQ1	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	IDA	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	MOUSE|MGI=MGI=109526|UniProtKB=Q9QZC1	Short transient receptor potential channel 3	IDA	11055438	PubMed	PTHR10117:SF8	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 3
P00006	Apoptosis signaling pathway	P00310	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MOUSE|MGI=MGI=2150393|UniProtKB=Q91ZU9	Glutamate receptor ionotropic, NMDA 3B	IC	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CRYNJ|EnsemblGenome=CNA04650|UniProtKB=Q5KP06	Actin	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00059	p53 pathway	P01486	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CHICK|Gene=ACTG2|UniProtKB=P63270	Actin, gamma-enteric smooth muscle	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00058	mRNA splicing	P01476	U4	SCHPO|PomBase=SPAC29A4.08c|UniProtKB=O14011	Pre-mRNA-processing factor 19	ISS			PTHR43995:SF1	PRE-MRNA-PROCESSING FACTOR 19
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	THEMA|EnsemblGenome=TM_0558|UniProtKB=Q9WZ28	Carbamoyl-phosphate synthase small chain	ISS			PTHR11405:SF4	CARBAMOYL-PHOSPHATE SYNTHASE ARGININE-SPECIFIC SMALL CHAIN
P00011	Blood coagulation	P00443	Fibrin polymer cross-linked	CHICK|Gene=FGB|UniProtKB=Q02020	Fibrinogen beta chain (Fragment)	ISS			PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00010	B cell activation	P00376	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IDA	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00046	Oxidative stress response	P01129	JNK1/2	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	HUMAN|HGNC=5286|UniProtKB=P08908	5-hydroxytryptamine receptor 1A	ISS	12441358	PubMed	PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P05915	Opioid proenkephalin pathway	P05994	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00055	Transcription regulation by bZIP transcription factor	P01396	TFIIFbeta	MACMU|Ensembl=ENSMMUG00000012634|UniProtKB=F7F069	General transcription factor IIF subunit 2	ISS			PTHR10445:SF0	GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2
P05731	GABA-B receptor II signaling	P05755	Gbeta	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05915	Opioid proenkephalin pathway	P05992	met-Enkephalin	DANRE|ZFIN=ZDB-GENE-030729-31|UniProtKB=A8E7S2	Uncharacterized protein	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00011	Blood coagulation	P00458	GP IIIa	HUMAN|Ensembl=ENSG00000259753|UniProtKB=H3BM21	Integrin beta (Fragment)	ISS	5805339	gi	PTHR10082:SF25	INTEGRIN BETA-3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	PANTR|Ensembl=ENSPTRG00000014418|UniProtKB=H2QLS0	Uncharacterized protein	ISS			PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CANLF|Ensembl=ENSCAFG00000013332|UniProtKB=F1PCQ4	Uncharacterized protein	ISS	7875593	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00049	Parkinson disease	P01212	p38 MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00018	EGF receptor signaling pathway	P00546	GAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000014976|UniProtKB=H2R892	Uncharacterized protein	ISS	20012997	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00025	Hedgehog signaling pathway	P00682	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	ISS	91072385	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P06587	Nicotine pharmacodynamics pathway	P06596	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12162872	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CHICK|Ensembl=ENSGALG00000009640|UniProtKB=F1P0I0	Muscarinic acetylcholine receptor	IDA	11166329	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	RCA			PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000002775|UniProtKB=H2RB55	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00029	Huntington disease	P00774	Dynein complex	BRAFL|Gene=BRAFLDRAFT_130244|UniProtKB=C3XVM4	Putative uncharacterized protein	ISS	9454836	PubMed	PTHR11886:SF62	DYNEIN, LIGHT CHAIN, LC8-TYPE 2
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MACMU|Ensembl=ENSMMUG00000005185|UniProtKB=F7CYN6	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF184	REGULATOR OF G-PROTEIN SIGNALING 4
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	RAT|RGD=3694|UniProtKB=Q01827	Synaptic vesicular amine transporter	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P05913	Enkephalin release	P05972	PKA	DROME|FlyBase=FBgn0000489|UniProtKB=P16912	Protein kinase DC2	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	RAT|RGD=69319|UniProtKB=P54313	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P02736	Coenzyme A biosynthesis	P02882	Pantothenate cysteine ligase	LEPIN|EnsemblGenome=LA_3935|UniProtKB=Q8EZC0	DNA/pantothenate metabolism flavoprotein	ISS			PTHR14359:SF6	PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	HUMAN|HGNC=4597|UniProtKB=P41594	Metabotropic glutamate receptor 5	ISS	8314195	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	FUSNN|EnsemblGenome=FN1014|UniProtKB=Q8RES8	Folylpolyglutamate synthase	ISS			PTHR11136:SF0	DIHYDROFOLATE SYNTHETASE-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00036	Interleukin signaling pathway	P00980	IRS1/2	PANTR|Ensembl=ENSPTRG00000012989|UniProtKB=H2QJJ4	Insulin receptor substrate 1	ISS	12701063	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000007576|UniProtKB=H2QA92	Uncharacterized protein	ISS	12441358	PubMed	PTHR24229:SF20	SOMATOSTATIN RECEPTOR TYPE 5
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	MONDO|Ensembl=ENSMODG00000018321|UniProtKB=Q6YNX4	Glycoprotein hormones alpha chain	ISS	89325834	PubMed	PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	MONDO|Ensembl=ENSMODG00000015696|UniProtKB=F7E0Q7	Fructose-bisphosphate aldolase	ISS	6086339	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00052	TGF-beta signaling pathway	P01286	TGFbeta	HUMAN|HGNC=1067|UniProtKB=P13497	Bone morphogenetic protein 1	TAS	9759503	PubMed	PTHR43978:SF3	BONE MORPHOGENETIC PROTEIN 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01162	MEK	CAEBR|Gene=CBG04190|UniProtKB=A8WWD7	Protein CBR-MEK-2	ISS	17508425	gi	PTHR24361:SF629	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1
P00006	Apoptosis signaling pathway	P00259	TNF	PANTR|Ensembl=ENSPTRG00000017966|UniProtKB=Q862Z7	Lymphotoxin-beta	ISS	1908877	PubMed	PTHR11471:SF29	LYMPHOTOXIN-BETA
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P02751	Lysine biosynthesis	P03011	N-succinyldiaminopimelate  aminotransferase	THEMA|EnsemblGenome=TM_1785|UniProtKB=Q9X2A5	Acetylornithine aminotransferase	IDA			PTHR11986:SF79	ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL
P00048	PI3 kinase pathway	P01199	Galpha	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00552	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PHYIT|EnsemblGenome=PITG_15078|UniProtKB=D0NRL5	Actin-like protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00056	VEGF signaling pathway	P01422	eNOS	BOVIN|Gene=NOS3|UniProtKB=P29473	Nitric oxide synthase, endothelial	ISS	9837777	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00004	Alzheimer disease-presenilin pathway	P00113	Erb-B4 transmembrane fragment	MACMU|Ensembl=ENSMMUG00000001674|UniProtKB=F7G3H1	Receptor protein-tyrosine kinase	ISS	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P02747	Histidine biosynthesis	P02986	Phosphoribosyl ATP pyrophosphatase	LEPIN|EnsemblGenome=LB_079|UniProtKB=Q8EXX8	Phosphoribosyl-ATP pyrophosphatase	ISS			PTHR42945:SF1	HISTIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN HISIE, CHLOROPLASTIC
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	RCA	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00513	Op18/stathmin	CHICK|Ensembl=ENSGALG00000016597|UniProtKB=E1BRN5	Stathmin	ISS			PTHR10104:SF6	STATHMIN-4
P00011	Blood coagulation	P00433	uPAR	MOUSE|MGI=MGI=97612|UniProtKB=P35456	Urokinase plasminogen activator surface receptor	ISS	7242179	gi	PTHR10624:SF6	UROKINASE PLASMINOGEN ACTIVATOR SURFACE RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347742|UniProtKB=E9FZ00	Cytoplasmatic actin	ISS	10974003	PubMed	PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00036	Interleukin signaling pathway	P00965	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MOUSE|MGI=MGI=95819|UniProtKB=P35438	Glutamate receptor ionotropic, NMDA 1	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MACMU|Ensembl=ENSMMUG00000022111|UniProtKB=F7H7W3	Ribosomal protein S6 kinase	ISS	2779569	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	TAKRU|Ensembl=ENSTRUG00000009851|UniProtKB=H2TJ90	Uncharacterized protein	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONBE|Gene=37852|UniProtKB=A9V489	Predicted protein	IDA	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00034	Integrin signalling pathway	P00931	Integrin beta	CANLF|Ensembl=ENSCAFG00000013735|UniProtKB=F1PPG5	Integrin beta	IDA	3487386	PubMed	PTHR10082:SF25	INTEGRIN BETA-3
P04392	P53 pathway feedback loops 1	P04539	p53	DANRE|ZFIN=ZDB-GENE-990415-270|UniProtKB=P79734	Cellular tumor antigen p53	TAS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P04393	Ras Pathway	P04547	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00049	Parkinson disease	P01212	p38 MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00029	Huntington disease	P00805	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	HUMAN|HGNC=11844|UniProtKB=Q9Y6L7	Tolloid-like protein 2	TAS	9759503	PubMed	PTHR43978:SF1	TOLLOID-LIKE PROTEIN 2
P04378	Beta2 adrenergic receptor signaling pathway	P04440	Beta2	HUMAN|HGNC=286|UniProtKB=P07550	Beta-2 adrenergic receptor	ISS	7669252	PubMed	PTHR24248:SF21	BETA-2 ADRENERGIC RECEPTOR
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	STRCO|EnsemblGenome=CAB93363|UniProtKB=Q9KXR6	Carbamoyl-phosphate synthase large chain	ISS			PTHR11405:SF5	CAD PROTEIN
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01471	alpha-catenin	MOUSE|MGI=MGI=88274|UniProtKB=P26231	Catenin alpha-1	IDA	1768802	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_126324|UniProtKB=C3XYC2	Putative uncharacterized protein	IDA	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	RCA			PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IDA	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00059	p53 pathway	P01485	p53	RAT|RGD=620863|UniProtKB=Q9JJP6	Tumor protein 63	TAS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05915	Opioid proenkephalin pathway	P05994	G-protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	ISS	10704417	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	DICPU|Gene=DICPUDRAFT_91367|UniProtKB=F0ZB76	Putative uncharacterized protein rasD	ISS	85024887	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00021	FGF signaling pathway	P00632	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IGI	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	RAT|RGD=3381|UniProtKB=P62716	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00629	PP2A	RAT|RGD=6503701|UniProtKB=F1MAA3	Protein LOC100909464	ISS	10092233	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00127	APP	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00034	Integrin signalling pathway	P00907	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	IDA	11790551	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00729	Goalpha	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	IDA	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BOVIN|Ensembl=ENSBTAG00000013017|UniProtKB=P04696	Guanine nucleotide-binding protein G(t) subunit alpha-2	ISS	10188796	PubMed	PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	RAT|RGD=2522|UniProtKB=P30729	D(4) dopamine receptor	ISS	2039532	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00646	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	11847220	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000012036|UniProtKB=F7ALP1	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00037	Ionotropic glutamate receptor pathway	P00999	PSD95	CAEBR|Gene=CBG02907|UniProtKB=A8WT89	Protein CBR-SHN-1	ISS	20020275	PubMed	PTHR24172:SF9	CUTICULAR PROTEIN 73D, ISOFORM B
P00021	FGF signaling pathway	P00634	MEKK1-5	MACMU|Ensembl=ENSMMUG00000012387|UniProtKB=F7EB20	Uncharacterized protein	ISS	12049732	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=12786|UniProtKB=O00755	Protein Wnt-7a	IDA	11266476	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00048	PI3 kinase pathway	P01179	PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	MONDO|Ensembl=ENSMODG00000001807|UniProtKB=F6Y7R9	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00018	EGF receptor signaling pathway	P00560	Raf-1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IGI	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00645	Rac	CAEEL|WormBase=WBGene00003239|UniProtKB=G5EBV3	Rac-like GTPase	IGI			PTHR24072:SF157	AT17867P
P00059	p53 pathway	P04612	HDAC1	TAKRU|Ensembl=ENSTRUG00000005364|UniProtKB=H2SKE2	Histone deacetylase	ISS	10485845	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P00037	Ionotropic glutamate receptor pathway	P01026	KA	BOVIN|Ensembl=ENSBTAG00000034854|UniProtKB=F1N246	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00035	Interferon-gamma signaling pathway	P00961	STAT1	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	14984365	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P02788	Xanthine and guanine salvage pathway	P03247	Xanthine phosphoribosyl transferase	FUSNN|EnsemblGenome=FN0288|UniProtKB=Q8RGK5	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	PANTR|Ensembl=ENSPTRG00000013316|UniProtKB=H2QK23	Uncharacterized protein	ISS			PTHR24229:SF52	SOMATOSTATIN RECEPTOR TYPE 4
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	IXOSC|EnsemblGenome=ISCW024111|UniProtKB=B7PBG2	Actin, putative (Fragment)	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000003043|UniProtKB=P63212	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00021	FGF signaling pathway	P00629	PP2A	MOUSE|MGI=MGI=1349475|UniProtKB=Q60996	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	ISS	8576224	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	HUMAN|HGNC=16767|UniProtKB=Q8TCU5	Glutamate receptor ionotropic, NMDA 3A	ISS	11554549	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00060	Ubiquitin proteasome pathway	P01491	E2	DANRE|ZFIN=ZDB-GENE-070424-86|UniProtKB=A4QNX5	Uncharacterized protein	ISS			PTHR24068:SF24	UBIQUITIN-CONJUGATING ENZYME E2 D4
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	CHICK|Ensembl=ENSGALG00000012444|UniProtKB=Q90669	Activin receptor type-2A	TAS	9395284	PubMed	PTHR23255:SF64	ACTIVIN RECEPTOR TYPE-2A
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00243	Raf	CAEEL|WormBase=WBGene00003030|UniProtKB=Q07292	Raf homolog serine/threonine-protein kinase	ISS			PTHR44000:SF2	RAF HOMOLOG SERINE/THREONINE-PROTEIN KINASE PHL
P00029	Huntington disease	P00774	Dynein complex	XENTR|Ensembl=ENSXETG00000034056|UniProtKB=F6XKW0	Uncharacterized protein	ISS	9454836	PubMed	PTHR10676:SF314	CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05918	p38 MAPK pathway	P06031	p38alpha	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	RAT|RGD=62029|UniProtKB=P02563	Myosin-6	ISS	10938134	PubMed	PTHR13140:SF721	MYOSIN-6
P04398	p53 pathway feedback loops 2	P04665	AKT	XENTR|Xenbase=XB-GENE-484168|UniProtKB=B1WB72	Akt2 protein	ISS			PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01411	Ras	XENTR|Xenbase=XB-GENE-494548|UniProtKB=F7EC26	Uncharacterized protein	ISS	10825661	PubMed	PTHR24070:SF186	GTPASE KRAS
P00053	T cell activation	P01320	PLC-gamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00519	ROCK	DROME|FlyBase=FBgn0026181|UniProtKB=Q9VXE3	Rho-associated protein kinase	ISS			PTHR22988:SF38	RHO-ASSOCIATED PROTEIN KINASE
P00029	Huntington disease	P00790	beta-Tubulin	MONDO|Ensembl=ENSMODG00000024011|UniProtKB=F7CGM4	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P04395	Vasopressin synthesis	P04589	Signal Peptidase	HUMAN|HGNC=26212|UniProtKB=P61009	Signal peptidase complex subunit 3	IC	1546959	PubMed	PTHR12804:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 3
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DROME|FlyBase=FBgn0004623|UniProtKB=P29829	Guanine nucleotide-binding protein subunit beta-2	IC			PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P05734	Synaptic vesicle trafficking	P05780	Rab3A	ORNAN|Ensembl=ENSOANG00000001291|UniProtKB=F7FXE2	Uncharacterized protein	ISS	9194562	PubMed	PTHR24073:SF532	RAS-RELATED PROTEIN RAB-3A
P00034	Integrin signalling pathway	P00922	Collagen	CHICK|Ensembl=ENSGALG00000006126|UniProtKB=P15988	Collagen alpha-2(VI) chain	IDA	10778855	PubMed	PTHR44172:SF1	COLLAGEN ALPHA-2 VI  CHAIN
P00057	Wnt signaling pathway	P01456	beta-arrestin	RAT|RGD=2156|UniProtKB=P29066	Beta-arrestin-1	IDA	4757780	gi	PTHR11792:SF22	BETA-ARRESTIN-1
P05918	p38 MAPK pathway	P06029	p38beta	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P02776	Serine glycine biosynthesis	P03160	Phosphoglycerate dehydrogenase	PYRAE|EnsemblGenome=PAE3320|UniProtKB=Q8ZTC7	D-3-phosphoglycerate dehydrogenase (SerA)	ISS			PTHR42938:SF9	FORMATE DEHYDROGENASE 1-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	RCA			PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00057	Wnt signaling pathway	P01452	NFAT	MACMU|Ensembl=ENSMMUG00000012657|UniProtKB=F7E7J1	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00059	p53 pathway	P04630	PP2A	BRAFL|Gene=BRAFLDRAFT_123893|UniProtKB=C3XQF4	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00586	Gq	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00319	TRADD	DANRE|ZFIN=ZDB-GENE-000511-5|UniProtKB=Q9I9N5	Tumor necrosis factor receptor type 1-associated DEATH domain protein	ISS			PTHR14913:SF0	TUMOR NECROSIS FACTOR RECEPTOR TYPE 1-ASSOCIATED DEATH DOMAIN PROTEIN
P02755	Methylmalonyl pathway	P03033	Propionyl-CoA carboxylase	THEKO|EnsemblGenome=TK1622|UniProtKB=Q5JIS8	Methylmalonyl-CoA decarboxylase, alpha subunit	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P00053	T cell activation	P01332	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	CHICK|Ensembl=ENSGALG00000015184|UniProtKB=F1N9Y3	Uncharacterized protein	ISS	9783586	PubMed	PTHR10814:SF21	TRANSDUCIN-LIKE ENHANCER PROTEIN 4
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	SYNY3|EnsemblGenome=BAA10261|UniProtKB=Q55128	Aspartate aminotransferase	ISS			PTHR11751:SF306	SUBFAMILY NOT NAMED
P00053	T cell activation	P01324	rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04546	GSK3	MACMU|Ensembl=ENSMMUG00000014597|UniProtKB=F6VAQ6	Glycogen synthase kinase-3 alpha	ISS	12086949	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00053	T cell activation	P01336	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IGI	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00591	PLCbeta	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	MACMU|Ensembl=ENSMMUG00000010184|UniProtKB=F6SR09	Uncharacterized protein	ISS	14614461	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00019	Endothelin signaling pathway	P00568	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IGI	7492337	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	BOVIN|Ensembl=ENSBTAG00000011761|UniProtKB=F1MDE1	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00053	T cell activation	P01322	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00011	Blood coagulation	P00441	FXIIa	PANTR|Ensembl=ENSPTRG00000017583|UniProtKB=H2QS39	Uncharacterized protein	ISS	4503629	gi	PTHR44246:SF3	COAGULATION FACTOR XII
P00057	Wnt signaling pathway	P01452	NFAT	PANTR|Ensembl=ENSPTRG00000013628|UniProtKB=H2R4F5	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MONDO|Ensembl=ENSMODG00000016448|UniProtKB=F7A479	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF135	BONE MORPHOGENETIC PROTEIN 7
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	HUMAN|HGNC=1951|UniProtKB=P08172	Muscarinic acetylcholine receptor M2	TAS	12181435	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00049	Parkinson disease	P01211	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	9298898	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	RAT|RGD=2035|UniProtKB=Q03343	Adenylate cyclase type 6	IGI	93028552	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00054	Toll receptor signaling pathway	P01352	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00048	PI3 kinase pathway	G01545	scl-1	CAEEL|WormBase=WBGene00008030|UniProtKB=Q18540	SCP-Like extracellular protein	ISS			PTHR10334:SF253	SCP-LIKE EXTRACELLULAR PROTEIN
P02738	De novo purine biosynthesis	P02904	Guanylate kinase	HUMAN|HGNC=4693|UniProtKB=Q16774	Guanylate kinase	ISS			PTHR23117:SF13	GUANYLATE KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS	88311074	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00019	Endothelin signaling pathway	P00568	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IDA	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	IDA	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05915	Opioid proenkephalin pathway	P05988	peptide E	DANRE|ZFIN=ZDB-GENE-030729-31|UniProtKB=A8E7S2	Uncharacterized protein	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00016	Cytoskeletal regulation by Rho GTPase	P00514	MLCK	PANTR|Ensembl=ENSPTRG00000008081|UniProtKB=H2QB15	Uncharacterized protein	ISS	600922	OMIM	PTHR45411:SF1	MYOSIN LIGHT CHAIN KINASE 3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IDA	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00627	ERK1-2	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CAEBR|Gene=CBG18256|UniProtKB=A8XS95	Protein CBR-ACT-5	ISS	11889126	PubMed	PTHR11937:SF352	ACTIN
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00036	Interleukin signaling pathway	P00976	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00029	Huntington disease	P00796	Kainate receptor	RAT|RGD=2732|UniProtKB=P22756	Glutamate receptor ionotropic, kainate 1	IDA	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	PANTR|Gene=ALDOA|UniProtKB=A5A6I5	Fructose-bisphosphate aldolase A	ISS	74094688	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00005	Angiogenesis	P00238	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	P01451	Galpha	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00036	Interleukin signaling pathway	P00983	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	MOUSE|MGI=MGI=1298218|UniProtKB=O88572	Low-density lipoprotein receptor-related protein 6	IDA	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00029	Huntington disease	P00810	GAPDH	PANTR|Ensembl=ENSPTRG00000004577|UniProtKB=H2Q5A6	Glyceraldehyde-3-phosphate dehydrogenase	ISS	8612237	PubMed	PTHR10836:SF51	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE
P00029	Huntington disease	P00807	Actin	DICPU|Gene=DICPUDRAFT_90232|UniProtKB=F1A175	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00012	Cadherin signaling pathway	P00462	Casein kinase II	DROME|FlyBase=FBgn0264492|UniProtKB=P08181	Casein kinase II subunit alpha	ISS	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	HUMAN|HGNC=4584|UniProtKB=Q05586	Glutamate receptor ionotropic, NMDA 1	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000010393|UniProtKB=F7D992	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00049	Parkinson disease	P01208	Hsp70	PLAF7|EnsemblGenome=PF08_0054|UniProtKB=Q8IB24	Heat shock protein 70	IDA	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00010	B cell activation	P00391	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01336	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	MONDO|Ensembl=ENSMODG00000009988|UniProtKB=F6UST7	Uncharacterized protein	ISS			PTHR11767:SF17	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 3
P00029	Huntington disease	P00789	PSD-95	PANTR|Ensembl=ENSPTRG00000008663|UniProtKB=H2QC23	Uncharacterized protein	ISS	12932731	PubMed	PTHR23119:SF33	DISKS LARGE HOMOLOG 4
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	HUMAN|HGNC=16767|UniProtKB=Q8TCU5	Glutamate receptor ionotropic, NMDA 3A	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00047	PDGF signaling pathway	P01173	STAT	MONDO|Ensembl=ENSMODG00000028212|UniProtKB=F7BYN4	Signal transducer and activator of transcription	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00036	Interleukin signaling pathway	P00990	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00059	p53 pathway	P04626	GADD45	MACMU|Ensembl=ENSMMUG00000006813|UniProtKB=F7GZG4	Cytokine-responsive protein CR6	ISS	10097101	PubMed	PTHR10411:SF4	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 GAMMA
P04393	Ras Pathway	P04547	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IC	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	RCA			PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00003	Alzheimer disease-amyloid secretase pathway	P00095	Nicastrin	RAT|RGD=631418|UniProtKB=Q8CGU6	Nicastrin	IDA	10993067	PubMed	PTHR21092:SF0	NICASTRIN
P00049	Parkinson disease	P01208	Hsp70	MONDO|Ensembl=ENSMODG00000012083|UniProtKB=F7G4T9	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	CAEEL|WormBase=WBGene00018569|UniProtKB=Q7JP68	cAMP-dependent protein kinase, catalytic subunit-like	ISS	1319556	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00020	FAS signaling pathway	P00615	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	TAS	11707292	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00057	Wnt signaling pathway	P01457	GBeta	IXOSC|EnsemblGenome=ISCW009711|UniProtKB=B7Q3T6	THO complex subunit, putative	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00059	p53 pathway	G01579	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	CHICK|Ensembl=ENSGALG00000019382|UniProtKB=E1BWK1	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00010	B cell activation	P00385	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00057	Wnt signaling pathway	P01454	betaTrCP	MONDO|Ensembl=ENSMODG00000011788|UniProtKB=F7CC58	Uncharacterized protein	ISS	10074433	PubMed	PTHR44038:SF2	F-BOX/WD REPEAT-CONTAINING PROTEIN 1A
P00010	B cell activation	P00391	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000022319|UniProtKB=F6XDA0	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00018	EGF receptor signaling pathway	P00557	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	IDA	8920915	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00628	JNK1-3	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	BOVIN|Ensembl=ENSBTAG00000040128|UniProtKB=F1MLJ8	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF23	FRIZZLED-4
P00029	Huntington disease	P00774	Dynein complex	CHLRE|EnsemblGenome=CHLREDRAFT_137221|UniProtKB=A8IUF0	Flagellar inner arm dynein 1 heavy chain beta	IPI	9454836	PubMed	PTHR10676:SF183	DYNEIN HEAVY CHAIN 2, AXONEMAL
P00045	Notch signaling pathway	P01119	NIct	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	IC	176892	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00020	FAS signaling pathway	P00604	Pro-Caspase8	RAT|RGD=620945|UniProtKB=Q9JHX4	Caspase-8	IGI	11788820	PubMed	PTHR10454:SF162	CASPASE-8
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00049	Parkinson disease	P01238	14-3-3	CHICK|Gene_ORFName=RCJMB04_5e12|UniProtKB=Q5F3W6	14-3-3 protein gamma	ISS	10407019	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00057	Wnt signaling pathway	P01429	Axin	MACMU|Ensembl=ENSMMUG00000000605|UniProtKB=F6Y8V8	Uncharacterized protein	ISS	12356903	PubMed	PTHR10845:SF11	AXIN-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04397	p53 pathway by glucose deprivation	P04639	AMPK	BOVIN|Ensembl=ENSBTAG00000018747|UniProtKB=F1MQV7	Uncharacterized protein	ISS			PTHR24343:SF303	5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-2
P00004	Alzheimer disease-presenilin pathway	P00131	HAC1	BOVIN|Ensembl=ENSBTAG00000003565|UniProtKB=A7MB36	TRIM3 protein	ISS			PTHR44028:SF1	TRIPARTITE MOTIF-CONTAINING PROTEIN 3
P00046	Oxidative stress response	P01124	Myc	RAT|RGD=3130|UniProtKB=P09416	Myc proto-oncogene protein	TAS	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MACMU|Ensembl=ENSMMUG00000006915|UniProtKB=F7EZ32	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00186	FGFR-1	BOVIN|Ensembl=ENSBTAG00000015457|UniProtKB=A4IFL5	Fibroblast growth factor receptor	ISS	1708247	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	BOVIN|Ensembl=ENSBTAG00000035697|UniProtKB=Q28024	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	15737619	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P04376	5HT4 type receptor mediated signaling pathway	P04427	5HT4 Receptor	RAT|RGD=2850|UniProtKB=Q62758	5-hydroxytryptamine receptor 4	ISS	12441358	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P00029	Huntington disease	P00790	beta-Tubulin	MACMU|Ensembl=ENSMMUG00000023785|UniProtKB=F7HTD6	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04397	p53 pathway by glucose deprivation	P04636	S6K	DANRE|ZFIN=ZDB-GENE-040426-2038|UniProtKB=F1R3V1	Ribosomal protein S6 kinase	ISS			PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00056	VEGF signaling pathway	P01408	Akt/PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00269	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00022	General transcription by RNA polymerase I	P00651	TAF-IA	XENTR|Xenbase=XB-GENE-491356|UniProtKB=Q28J24	Transcription initiation factor TFIID subunit 8	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00005	Angiogenesis	P00219	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04392	P53 pathway feedback loops 1	P04539	p53	RAT|RGD=3889|UniProtKB=P10361	Cellular tumor antigen p53	TAS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Gene=DRD2|UniProtKB=Q9GJU1	D(2) dopamine receptor	IDA	11861492	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2521|UniProtKB=P19020	D(3) dopamine receptor	IDA	11248120	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00049	Parkinson disease	P01212	p38 MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00545	JNK1-3	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	IGI			PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00059	p53 pathway	P04623	CBP	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00010	B cell activation	P00368	vav	MOUSE|MGI=MGI=98923|UniProtKB=P27870	Proto-oncogene vav	IGI	10661401	PubMed	PTHR22826:SF112	PROTO-ONCOGENE VAV
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	DROME|FlyBase=FBgn0004611|UniProtKB=P25455	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00050	Plasminogen activating cascade	P01253	Fibrin	BOVIN|Gene=FGG|UniProtKB=P12799	Fibrinogen gamma-B chain	ISS	120140	gi	PTHR19143:SF338	FIBRINOGEN GAMMA CHAIN
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IDA	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00046	Oxidative stress response	P01129	JNK1/2	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00052	TGF-beta signaling pathway	P01275	P38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00036	Interleukin signaling pathway	P00964	p90RSK	PANTR|Ensembl=ENSPTRG00000022064|UniProtKB=H2QYE0	Uncharacterized protein	ISS	15632195	PubMed	PTHR24351:SF98	RIBOSOMAL PROTEIN S6 KINASE ALPHA-6
P00048	PI3 kinase pathway	P01199	Galpha	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P06664	Gonadotropin-releasing hormone receptor pathway	P06832	c-Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	RCA	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	SCHMA|EnsemblGenome=Smp_165490|UniProtKB=C1LZY9	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01179	PKB	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	TAS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01188	Gbetagamma	HUMAN|HGNC=4401|UniProtKB=O14775	Guanine nucleotide-binding protein subunit beta-5	IC	9754712	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00054	Toll receptor signaling pathway	P01338	IkappaB	MACMU|Ensembl=ENSMMUG00000020374|UniProtKB=F6UMS2	NF-kappa-B inhibitor alpha	ISS	14665694	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00036	Interleukin signaling pathway	P00973	PKB	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MONDO|Ensembl=ENSMODG00000016960|UniProtKB=F6V5G0	Uncharacterized protein	ISS	20012997	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	HUMAN|HGNC=167|UniProtKB=P61163	Alpha-centractin	IC	14684598	PubMed	PTHR11937:SF46	ALPHA-CENTRACTIN
P00048	PI3 kinase pathway	P01188	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000002674|UniProtKB=P02698	Guanine nucleotide-binding protein G(T) subunit gamma-T1	IC	3100519	PubMed	PTHR13809:SF26	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT GAMMA-T1
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	CIOIN|Ensembl=ENSCING00000009515|UniProtKB=Q8T3S5	Casein kinase 2 alpha subunit	IDA	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	XENTR|Xenbase=XB-GENE-967585|UniProtKB=Q28BZ0	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00057	Wnt signaling pathway	P01428	Frizzled	MOUSE|MGI=MGI=108476|UniProtKB=Q61086	Frizzled-3	IDA	8717036	PubMed	PTHR11309:SF22	FRIZZLED-3
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00628	JNK1-3	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04396	Vitamin D metabolism and pathway	P04600	DBP	RAT|RGD=2667|UniProtKB=P04276	Vitamin D-binding protein	IPI	11799400	PubMed	PTHR11385:SF11	VITAMIN D-BINDING PROTEIN
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00014	Cholesterol biosynthesis	P00491	Hydroxymethyl glutaryl CoA reductase	DICPU|Gene=DICPUDRAFT_149815|UniProtKB=F0ZER0	3-hydroxy-3-methylglutaryl coenzyme A reductase	ISS	P34136	SPACC	PTHR10572:SF16	3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000014334|UniProtKB=F7CYY6	Uncharacterized protein	ISS	2137198	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_125401|UniProtKB=C3ZTX6	Putative uncharacterized protein	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00020	FAS signaling pathway	P00610	MKK4	MONDO|Ensembl=ENSMODG00000008266|UniProtKB=F6Z879	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IDA	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00004	Alzheimer disease-presenilin pathway	P00114	actin	XENTR|Xenbase=XB-GENE-490883|UniProtKB=Q6NVA9	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00011	Blood coagulation	P00451	Kininogen	BOVIN|Gene=KNG1|UniProtKB=P01044	Kininogen-1	ISS	125505	gi	PTHR13814:SF12	KININOGEN-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00848	Grb	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12162872	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	ORNAN|Ensembl=ENSOANG00000014684|UniProtKB=F7CX67	Uncharacterized protein	ISS	415387	gi	PTHR10773:SF12	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2
P00019	Endothelin signaling pathway	P00566	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04567	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	IDA	14526383	PubMed	PTHR10048:SF14	PI-3 KINASE
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	SULSO|EnsemblGenome=SSO2070|UniProtKB=Q97WQ0	Acetyl-CoA synthetase (Acetate-CoA ligase) (AcsA-7)	ISS			PTHR24095:SF14	ACETYL-COENZYME A SYNTHETASE 1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	XENTR|Xenbase=XB-GENE-492636|UniProtKB=F7D1A1	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05934	ELK1	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	RCA	10487205	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	PANTR|Ensembl=ENSPTRG00000008770|UniProtKB=H2QC99	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF385	MYOSIN-2
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00056	VEGF signaling pathway	P01408	Akt/PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	CHICK|Ensembl=ENSGALG00000009621|UniProtKB=P60706	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00029	Huntington disease	P00807	Actin	ORNAN|Ensembl=ENSOANG00000007405|UniProtKB=F7CIV4	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00060	Ubiquitin proteasome pathway	P01491	E2	ORYSJ|EnsemblGenome=OS09G0297100|UniProtKB=Q69TB0	Os09g0297100 protein	ISS			PTHR43915:SF4	UBIQUITIN-CONJUGATING ENZYME E2 VARIANT 1D
P00039	Metabotropic glutamate receptor group III pathway	P01037	mGluR 5	CANLF|Ensembl=ENSCAFG00000004381|UniProtKB=J9JH96	Uncharacterized protein	ISS	7476890	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	10395542	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00018	EGF receptor signaling pathway	P00551	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	IGI	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	2837282	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	IDA	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00057	Wnt signaling pathway	P01443	Phospholipase C	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00053	T cell activation	P01311	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00833	RGS	RAT|RGD=1306522|UniProtKB=Q4L0E8	Regulator of G-protein signaling 18	ISS	8756726	PubMed	PTHR10845:SF155	REGULATOR OF G-PROTEIN SIGNALING 18
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	XENTR|Xenbase=XB-GENE-967585|UniProtKB=Q28BZ0	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00034	Integrin signalling pathway	P00948	Rho	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	IGI	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P04395	Vasopressin synthesis	P04594	Neurophysin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00029	Huntington disease	G01530	HTT	MACMU|Ensembl=ENSMMUG00000008392|UniProtKB=F6VQZ3	Uncharacterized protein	ISS	7620118	PubMed	PTHR10170:SF10	HUNTINGTIN
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00925	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MOUSE|MGI=MGI=1309999|UniProtKB=Q922R0	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00056	VEGF signaling pathway	P01407	Erk	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00047	PDGF signaling pathway	P01148	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	8262390	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00019	Endothelin signaling pathway	P00590	IP3 R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00045	Notch signaling pathway	P01110	Presenilin	CHICK|Ensembl=ENSGALG00000009320|UniProtKB=Q4JIM4	Presenilin-1	ISS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CHLRE|EnsemblGenome=CHLREDRAFT_168932|UniProtKB=O24426	Actin-like protein	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	RCA			PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CAEEL|WormBase=WBGene00001187|UniProtKB=Q8MQA1	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P05913	Enkephalin release	P05977	G-Protein (s)	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00011	Blood coagulation	P00412	PS	PANTR|Ensembl=ENSPTRG00000015128|UniProtKB=H2QMY8	Protein S (Alpha)	ISS	87092407	PubMed	PTHR24040:SF0	VITAMIN K-DEPENDENT PROTEIN S
P00021	FGF signaling pathway	P00629	PP2A	ARATH|TAIR=AT1G13460|UniProtKB=Q8LF36	Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform	ISS			PTHR10257:SF46	SERINE/THREONINE PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B' DELTA ISOFORM-RELATED
P00012	Cadherin signaling pathway	P00464	Fyn	MONDO|Ensembl=ENSMODG00000017905|UniProtKB=F7FG65	Tyrosine-protein kinase	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00005	Angiogenesis	P00189	Fzd	CANLF|Ensembl=ENSCAFG00000013547|UniProtKB=E2QVP7	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF126	FRIZZLED-5
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P06587	Nicotine pharmacodynamics pathway	P06604	SLC18A2	PANTR|Ensembl=ENSPTRG00000002979|UniProtKB=H2Q2M8	Uncharacterized protein	ISS	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00059	p53 pathway	P04633	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_115291|UniProtKB=C3ZMR2	Putative uncharacterized protein	ISS			PTHR11937:SF359	SUBFAMILY NOT NAMED
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	BOVIN|Gene=ARPC5|UniProtKB=Q3SYX9	Actin-related protein 2/3 complex subunit 5	ISS	10322212	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05915	Opioid proenkephalin pathway	P05992	met-Enkephalin	MOUSE|MGI=MGI=104629|UniProtKB=P22005	Proenkephalin-A	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00037	Ionotropic glutamate receptor pathway	P01026	KA	XENTR|Xenbase=XB-GENE-957124|UniProtKB=F7BDN8	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00053	T cell activation	P01305	Calmodulin	TAKRU|Ensembl=ENSTRUG00000003442|UniProtKB=H2S6Q5	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF197	CALMODULIN-LIKE PROTEIN 3
P00057	Wnt signaling pathway	P01444	Wnt	BRAFL|Gene=BRAFLDRAFT_271417|UniProtKB=C3ZCG7	Protein Wnt	IDA	8717036	PubMed	PTHR12027:SF102	PROTEIN WNT-4
P06664	Gonadotropin-releasing hormone receptor pathway	P06768	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	RCA	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF248	SUBFAMILY NOT NAMED
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00049	Parkinson disease	P01211	ERK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	IDA	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00059	p53 pathway	P04633	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05918	p38 MAPK pathway	P06039	MSK2	RAT|RGD=1307277|UniProtKB=D3ZSB7	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF41	RIBOSOMAL PROTEIN S6 KINASE ALPHA-4
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	HUMAN|HGNC=6017|UniProtKB=Q01344	Interleukin-5 receptor subunit alpha	IC	1732409	PubMed	PTHR23036:SF17	INTERLEUKIN-5 RECEPTOR SUBUNIT ALPHA
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	STRPU|EnsemblGenome=SPU_018419|UniProtKB=W4YRI6	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01458	Protein Kinase C	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	IDA	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00005	Angiogenesis	P00234	Grb2	DANRE|ZFIN=ZDB-GENE-040426-1975|UniProtKB=Q6PC73	Growth factor receptor-bound protein 2	ISS	http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd	Website	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00005	Angiogenesis	P00223	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	YEAST|SGD=S000003478|UniProtKB=P29056	Transcription factor IIIB 70 kDa subunit	ISS			PTHR11618:SF4	TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01023	CaMKII	CHICK|Ensembl=ENSGALG00000005621|UniProtKB=F1NGS8	Uncharacterized protein	ISS	10092204	PubMed	PTHR43940:SF5	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02729	Ascorbate degradation	P02852	L-xylulose-5-phosphate-3-epimerase	FUSNN|EnsemblGenome=FN0680|UniProtKB=Q8RFL5	Ribulose-phosphate 3-epimerase	ISS			PTHR11749:SF3	RIBULOSE-PHOSPHATE 3-EPIMERASE
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00005	Angiogenesis	P00218	STAT1	HUMAN|HGNC=11362|UniProtKB=P42224	Signal transducer and activator of transcription 1-alpha/beta	IDA	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00047	PDGF signaling pathway	P01168	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	129387	gi	PTHR10048:SF14	PI-3 KINASE
P00048	PI3 kinase pathway	P01206	14-3-3	MACMU|Ensembl=ENSMMUG00000006489|UniProtKB=F7EFF6	14-3-3 protein zeta/delta	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00005	Angiogenesis	P00239	Eph	CANLF|Ensembl=ENSCAFG00000006022|UniProtKB=F1Q2Q5	Uncharacterized protein	ISS	9990854	PubMed	PTHR11304:SF18	EPHRIN-B2
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	RAT|RGD=619965|UniProtKB=P26769	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00047	PDGF signaling pathway	P01162	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00057	Wnt signaling pathway	P01444	Wnt	BOVIN|Ensembl=ENSBTAG00000005570|UniProtKB=E1BKL2	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P02755	Methylmalonyl pathway	P03032	Methylmalonyl-CoA epimerase	MOUSE|MGI=MGI=1920974|UniProtKB=Q9D1I5	Methylmalonyl-CoA epimerase, mitochondrial	ISS			PTHR43048:SF3	METHYLMALONYL-COA EPIMERASE, MITOCHONDRIAL
P04398	p53 pathway feedback loops 2	P04666	cyclin A	MACMU|Ensembl=ENSMMUG00000009817|UniProtKB=F6WZV1	Cyclin-A2	ISS			PTHR10177:SF69	CYCLIN-A2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	IPI	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	XENTR|Xenbase=XB-GENE-977853|UniProtKB=F7EBE7	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00054	Toll receptor signaling pathway	P01370	TAK1	MOUSE|MGI=MGI=1346877|UniProtKB=Q62073	Mitogen-activated protein kinase kinase kinase 7	ISS	10683140	PubMed	PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P00060	Ubiquitin proteasome pathway	P01490	E3	SCHPO|PomBase=SPAC11G7.02|UniProtKB=Q92462	E3 ubiquitin-protein ligase pub1	ISS			PTHR11254:SF67	E3 UBIQUITIN-PROTEIN LIGASE NEDD-4
P00034	Integrin signalling pathway	P00923	Arf1	DICPU|Gene=DICPUDRAFT_93077|UniProtKB=F1A1N6	ADP-ribosylation factor 1	ISS	11752622	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P05918	p38 MAPK pathway	P06020	p38delta	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	RCA	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00012	Cadherin signaling pathway	P00477	GSK3beta	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00048	PI3 kinase pathway	P01199	Galpha	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	IC	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	PANTR|Gene=CHRM2|UniProtKB=Q9N2A7	Muscarinic acetylcholine receptor M2 (Fragment)	ISS			PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P05912	Dopamine receptor mediated signaling pathway	P05961	DOPA decarb.	RAT|RGD=2494|UniProtKB=P14173	Aromatic-L-amino-acid decarboxylase	ISS	7567987	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=97441|UniProtKB=P42866	Mu-type opioid receptor	IDA	11259498	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P05730	Endogenous cannabinoid signaling	P05751	Galpha	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00747	Rhodopsin	MONDO|Ensembl=ENSMODG00000006488|UniProtKB=F7F2J1	Rhodopsin	ISS	1634520	PubMed	PTHR24240:SF15	RHODOPSIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000018853|UniProtKB=F6XSK8	Uncharacterized protein	ISS	12181435	PubMed	PTHR24229:SF42	SOMATOSTATIN RECEPTOR TYPE 3
P00057	Wnt signaling pathway	P01429	Axin	HUMAN|HGNC=903|UniProtKB=O15169	Axin-1	IDA	12356903	PubMed	PTHR10845:SF11	AXIN-1
P00057	Wnt signaling pathway	P01456	beta-arrestin	DROME|FlyBase=FBgn0000121|UniProtKB=P19107	Phosrestin-1	IC	11742073	PubMed	PTHR11792:SF23	PHOSRESTIN-1
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P02742	Tetrahydrofolate biosynthesis	P02951	GTP cyclohydrolase	PYRAE|EnsemblGenome=PAE1588|UniProtKB=Q8ZWW5	GTP cyclohydrolase 1	ISS			PTHR11109:SF0	GTP CYCLOHYDROLASE 1
P00022	General transcription by RNA polymerase I	P00655	UBF1	RAT|RGD=3927|UniProtKB=P25977	Nucleolar transcription factor 1	ISS	14612424	PubMed	PTHR13711:SF216	NUCLEOLAR TRANSCRIPTION FACTOR 1
P00011	Blood coagulation	P00455	GP IX	MACMU|Ensembl=ENSMMUG00000019799|UniProtKB=B8XNP5	Platelet glycoprotein IX polypeptide	ISS	91071429	PubMed	PTHR22650:SF6	PLATELET GLYCOPROTEIN IX
P04398	p53 pathway feedback loops 2	P04665	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	MACMU|Ensembl=ENSMMUG00000017431|UniProtKB=F7HPP3	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00054	Toll receptor signaling pathway	P01367	MKK3	MACMU|Ensembl=ENSMMUG00000010904|UniProtKB=F7GLY5	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	G06673	CGA	MOUSE|MGI=MGI=88390|UniProtKB=P01216	Glycoprotein hormones alpha chain	RCA	15927770	PubMed	PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	IGI	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00053	T cell activation	P01318	PKC-theta	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05913	Enkephalin release	P05971	CREB	XENTR|Xenbase=XB-GENE-945015|UniProtKB=F6QA46	Uncharacterized protein	ISS	11752053	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	STRCO|Gene=CAB89023|UniProtKB=Q9KZC7	Putative glutamine synthetase	ISS			PTHR43785:SF2	TYPE-1 GLUTAMINE SYNTHETASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	2372396	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	RAT|RGD=1560646|UniProtKB=D4A5I9	Protein Myo6	ISS			PTHR13140:SF706	UNCONVENTIONAL MYOSIN-VI
P04398	p53 pathway feedback loops 2	P04661	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05916	Opioid prodynorphin pathway	P06002	G-protein	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	ORYSJ|Gene=Os12g0625000|UniProtKB=Q9XEA6	Cysteine synthase	ISS			PTHR10314:SF160	CYSTEINE SYNTHASE 1-RELATED
P02728	Arginine biosynthesis	P02842	N-acetylornithine aminotransferase	METAC|EnsemblGenome=MA_0119|UniProtKB=Q8TUE8	Acetylornithine aminotransferase	ISS	10074354	PubMed	PTHR11986:SF79	ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL
P00053	T cell activation	P01300	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04651	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00029	Huntington disease	P00761	Truncated Htt	MOUSE|MGI=MGI=96067|UniProtKB=P42859	Huntingtin	TAS	8268927	PubMed	PTHR10170:SF10	HUNTINGTIN
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00009	Axon guidance mediated by netrin	P00366	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P02738	De novo purine biosynthesis	P02892	5-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase	MOUSE|MGI=MGI=103202|UniProtKB=P54822	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04572	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	IDA	8946915	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04372	5-Hydroxytryptamine degredation	P04401	Monoamine Oxidase	BOVIN|Gene=MAOB|UniProtKB=P56560	Amine oxidase [flavin-containing] B	ISS	90344230	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00009	Axon guidance mediated by netrin	P00356	UNC-5	MOUSE|MGI=MGI=2389364|UniProtKB=Q8K1S2	Netrin receptor UNC5D	ISS			PTHR12582:SF5	NETRIN RECEPTOR UNC5D
P00054	Toll receptor signaling pathway	P01356	ERK2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IDA	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	MOUSE|MGI=MGI=1920334|UniProtKB=Q8C015	Serine/threonine-protein kinase PAK 7	ISS			PTHR24361:SF183	SERINE/THREONINE-PROTEIN KINASE PAK 7
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	G01566	TSP1	MOUSE|MGI=MGI=98737|UniProtKB=P35441	Thrombospondin-1	IGI	7521539	PubMed	PTHR10199:SF78	THROMBOSPONDIN-1
P00021	FGF signaling pathway	P00638	PLCgamma	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CAEBR|Gene=CBG10871|UniProtKB=A8XC64	Protein CBR-ACR-2	ISS	22213672	PubMed	PTHR18945:SF744	ACETYLCHOLINE RECEPTOR SUBUNIT BETA-TYPE ACR-2
P00005	Angiogenesis	P00221	JNK1	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	HUMAN|HGNC=5295|UniProtKB=P28335	5-hydroxytryptamine receptor 2C	ISS	12181435	PubMed	PTHR24247:SF32	5-HYDROXYTRYPTAMINE RECEPTOR 2C
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=108061|UniProtKB=P48614	Protein Wnt-10b	IDA	8717036	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00029	Huntington disease	P00805	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MOUSE|MGI=MGI=99779|UniProtKB=P49582	Neuronal acetylcholine receptor subunit alpha-7	IC			PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P05913	Enkephalin release	P05974	G-Protein (i)	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00018	EGF receptor signaling pathway	P00558	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05913	Enkephalin release	P05974	G-Protein (i)	MONDO|Ensembl=ENSMODG00000005623|UniProtKB=F7CFG8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00046	Oxidative stress response	P01131	MKP5	BOVIN|Ensembl=ENSBTAG00000013863|UniProtKB=F1MI99	Dual specificity protein phosphatase	ISS			PTHR10159:SF309	DUAL SPECIFICITY PROTEIN PHOSPHATASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1693|UniProtKB=Q6P967	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00035	Interferon-gamma signaling pathway	P00956	SOCS	CHICK|Ensembl=ENSGALG00000013731|UniProtKB=B2WUP2	Suppressor of cytokine signaling 6	ISS	12645661	PubMed	PTHR44562:SF1	SUPPRESSOR OF CYTOKINE SIGNALING 6
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01411	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00010	B cell activation	P00376	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	HUMAN|HGNC=1424|UniProtKB=P27708	CAD protein	ISS			PTHR11405:SF5	CAD PROTEIN
P00018	EGF receptor signaling pathway	P00551	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IGI	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00019	Endothelin signaling pathway	P00577	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	XENTR|Xenbase=XB-GENE-491938|UniProtKB=Q6DIV8	Actin, alpha 1, skeletal muscle	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	ORNAN|Ensembl=ENSOANG00000003489|UniProtKB=F7FSE3	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04375	5HT3 type receptor mediated signaling pathway	P04425	K+ channel	CHICK|Ensembl=ENSGALG00000016193|UniProtKB=E1BYI0	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00012	Cadherin signaling pathway	P00467	alpha-catenin	MOUSE|MGI=MGI=88275|UniProtKB=Q61301	Catenin alpha-2	ISS	9362521	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IDA	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	CANLF|Ensembl=ENSCAFG00000010871|UniProtKB=F1PXA0	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-7595|UniProtKB=Q6PBR4	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00006	Apoptosis signaling pathway	P00270	Bcl-2	MOUSE|MGI=MGI=88138|UniProtKB=P10417	Apoptosis regulator Bcl-2	ISS	11323415	PubMed	PTHR11256:SF11	APOPTOSIS REGULATOR BCL-2
P00034	Integrin signalling pathway	P00918	Caveolin	MOUSE|MGI=MGI=102709|UniProtKB=P49817	Caveolin-1	ISS	9741627	PubMed	PTHR10844:SF18	CAVEOLIN-1
P00029	Huntington disease	P00770	N-CoR	CANLF|Ensembl=ENSCAFG00000006985|UniProtKB=F1PQQ7	Uncharacterized protein	ISS	11112321	PubMed	PTHR13992:SF21	NUCLEAR RECEPTOR COREPRESSOR 2
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	ANOGA|EnsemblGenome=AGAP005911|UniProtKB=Q7Q6D4	AGAP005911-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00897	SHIP2	CANLF|Ensembl=ENSCAFG00000005743|UniProtKB=F1PNY0	Uncharacterized protein	ISS	12145149	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00019	Endothelin signaling pathway	P00590	IP3 R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00035	Interferon-gamma signaling pathway	P00961	STAT1	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	15825084	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	HUMAN|HGNC=4579|UniProtKB=P39086	Glutamate receptor ionotropic, kainate 1	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00029	Huntington disease	P00805	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00920	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04393	Ras Pathway	P04558	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	IDA	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00048	PI3 kinase pathway	P01192	p110	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IDA	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00046	Oxidative stress response	P01129	JNK1/2	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	TAS	97320448	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	ARATH|TAIR=AT5G58670|UniProtKB=Q39032	Phosphoinositide phospholipase C 1	ISS			PTHR10336:SF105	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00012	Cadherin signaling pathway	P00470	F-actin	HUMAN|HGNC=143|UniProtKB=P68032	Actin, alpha cardiac muscle 1	IC	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00924	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	ARATH|TAIR=AT2G18170|UniProtKB=Q39027	Mitogen-activated protein kinase 7	TAS			PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P00024	Glycolysis	P00678	Enolase	HUMAN|HGNC=3350|UniProtKB=P06733	Alpha-enolase	ISS	99439677	PubMed	PTHR11902:SF12	ALPHA-ENOLASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DANRE|ZFIN=ZDB-GENE-000329-1|UniProtKB=Q7ZVI7	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00019	Endothelin signaling pathway	P00581	Guanylate cyclase	CAEEL|WormBase=WBGene00001556|UniProtKB=Q6DNF4	Soluble guanylate cyclase gcy-36	ISS			PTHR11920:SF449	SOLUBLE GUANYLATE CYCLASE GCY-36
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IDA	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00021	FGF signaling pathway	P00643	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00180	Dok-R	PANTR|Ensembl=ENSPTRG00000020043|UniProtKB=H2QVU0	Uncharacterized protein	ISS			PTHR21258:SF14	DOCKING PROTEIN 2
P00012	Cadherin signaling pathway	P00477	GSK3beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05918	p38 MAPK pathway	P06034	MKK4	MACMU|Ensembl=ENSMMUG00000019842|UniProtKB=F7FU91	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00046	Oxidative stress response	P01137	MNK1/2	MOUSE|MGI=MGI=894316|UniProtKB=O08605	MAP kinase-interacting serine/threonine-protein kinase 1	IDA	97299868	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00019	Endothelin signaling pathway	P00570	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	ISS	176892	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P05917	Opioid proopiomelanocortin pathway	P06010	proopiomelanocortin	HUMAN|HGNC=9201|UniProtKB=P01189	Pro-opiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P04397	p53 pathway by glucose deprivation	P04641	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00107	kinesin	ANOGA|EnsemblGenome=AGAP010258|UniProtKB=Q7PME6	AGAP010258-PA	IDA	11740561	PubMed	PTHR19959:SF207	KINESIN LIGHT CHAIN
P00010	B cell activation	P00386	Calcineurin	HUMAN|HGNC=9315|UniProtKB=P16298	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	IDA	12015605	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01331	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00040	Metabotropic glutamate receptor group II pathway	G01540	BDNF	HUMAN|HGNC=1033|UniProtKB=P23560	Brain-derived neurotrophic factor	ISS	11408619	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04375	5HT3 type receptor mediated signaling pathway	P04422	5HT3 Rec	MOUSE|MGI=MGI=96282|UniProtKB=P23979	5-hydroxytryptamine receptor 3A	ISS	7509203	PubMed	PTHR18945:SF52	5-HYDROXYTRYPTAMINE RECEPTOR 3A
P05915	Opioid proenkephalin pathway	P05988	peptide E	MOUSE|MGI=MGI=104629|UniProtKB=P22005	Proenkephalin-A	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00008	Axon guidance mediated by Slit/Robo	P00355	Rho	PANTR|Ensembl=ENSPTRG00000001112|UniProtKB=H2PZP2	Ras homolog gene family, member C	ISS	14871999	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	ISS	176910	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MOUSE|MGI=MGI=97250|UniProtKB=P01108	Myc proto-oncogene protein	IEP	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00122	NICD	MOUSE|MGI=MGI=97364|UniProtKB=O35516	Neurogenic locus notch homolog protein 2	IDA	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00019	Endothelin signaling pathway	P00572	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00045	Notch signaling pathway	G01541	E(spl)-C genes	DROME|FlyBase=FBgn0002609|UniProtKB=Q01068	Enhancer of split m3 protein	TAS	14973298	PubMed	PTHR10985:SF12	ENHANCER OF SPLIT M3 PROTEIN-RELATED
P00048	PI3 kinase pathway	P01188	Gbetagamma	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00025	Hedgehog signaling pathway	P00682	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	MOUSE|MGI=MGI=96538|UniProtKB=Q61727	Interleukin-10 receptor subunit alpha	IPI	8248239	PubMed	PTHR20859:SF43	INTERLEUKIN-10 RECEPTOR SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01173	STAT	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	ISS	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	XENTR|Xenbase=XB-GENE-478121|UniProtKB=F6VPH2	Uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00005	Angiogenesis	P00223	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00583	cPLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00021	FGF signaling pathway	P00628	JNK1-3	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IGI	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00565	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00034	Integrin signalling pathway	P00951	Jnk	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IDA	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00057	Wnt signaling pathway	P01448	CBP	CAEEL|WormBase=WBGene00000366|UniProtKB=P34545	Protein cbp-1	ISS	10823891	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PANTR|Ensembl=ENSPTRG00000008766|UniProtKB=H2QC97	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF504	MYOSIN-13
P00019	Endothelin signaling pathway	P00589	Akt	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	ISS	14526383	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	MOUSE|MGI=MGI=99684|UniProtKB=A2AGL3	Ryanodine receptor 3	ISS	15858232	PubMed	PTHR13715:SF16	RYANODINE RECEPTOR 3
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MOUSE|MGI=MGI=87906|UniProtKB=P63260	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00029	Huntington disease	P00780	Microtubule	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g229095|UniProtKB=A7S027	Predicted protein	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DAPPU|EnsemblGenome=DAPPUDRAFT_228751|UniProtKB=E9HGF5	Cytoplasmatic actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	STRPU|EnsemblGenome=SPU_017814|UniProtKB=W4YPT6	Uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF263	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	DANRE|ZFIN=ZDB-GENE-990415-9|UniProtKB=O73736	Receptor protein serine/threonine kinase	TAS	9395284	PubMed	PTHR23255:SF65	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00057	Wnt signaling pathway	P01438	PP2A	TAKRU|Ensembl=ENSTRUG00000008018|UniProtKB=H2T5N4	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	HUMAN|HGNC=10430|UniProtKB=Q15418	Ribosomal protein S6 kinase alpha-1	ISS	12769834	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00006	Apoptosis signaling pathway	P00274	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	ISS	97102675	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P02772	Pyruvate metabolism	P03137	Citrate Lyase	HUMAN|HGNC=18355|UniProtKB=Q8N0X4	Citrate lyase subunit beta-like protein, mitochondrial	ISS			PTHR11105:SF0	CITRATE LYASE SUBUNIT BETA-LIKE PROTEIN, MITOCHONDRIAL
P00011	Blood coagulation	P00431	tPA	PANTR|Ensembl=ENSPTRG00000020201|UniProtKB=H2QW33	Tissue-type plasminogen activator	ISS	6572897	PubMed	PTHR44617:SF1	TISSUE-TYPE PLASMINOGEN ACTIVATOR
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-8225|UniProtKB=Q7SZZ5	Uncharacterized protein	ISS			PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	IPI	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00059	p53 pathway	P04609	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00211	GSK3beta	CAEEL|WormBase=WBGene00001746|UniProtKB=Q9U2Q9	Glycogen synthase kinase-3	ISS			PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P02778	Sulfate assimilation	P03167	Sulfate adenylyltransferase	BACSU|EnsemblGenome=BSU10920|UniProtKB=O06736	Probable sulfate adenylyltransferase	ISS			PTHR43509:SF1	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04396	Vitamin D metabolism and pathway	P04605	P450 reductase	DROME|FlyBase=FBgn0015623|UniProtKB=Q27597	NADPH--cytochrome P450 reductase	TAS	2513880	PubMed	PTHR19384:SF17	NADPH--CYTOCHROME P450 REDUCTASE
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ORYSJ|EnsemblGenome=OS03G0285800|UniProtKB=Q10N20	Mitogen-activated protein kinase 5	IDA			PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_56698|UniProtKB=C3XYC3	Putative uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00006	Apoptosis signaling pathway	P00299	Caspase 8	PANTR|Ensembl=ENSPTRG00000012801|UniProtKB=H2QJ86	Caspase 8, apoptosis-related cysteine peptidase	ISS	8681376	PubMed	PTHR10454:SF162	CASPASE-8
P05913	Enkephalin release	P05974	G-Protein (i)	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	8170357	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04393	Ras Pathway	P04542	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01440	Cadherin	CANLF|Ensembl=ENSCAFG00000019841|UniProtKB=E2R4F0	Uncharacterized protein	ISS	8120095	PubMed	PTHR24026:SF32	CADHERIN EGF LAG SEVEN-PASS G-TYPE RECEPTOR 2
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	PANTR|Ensembl=ENSPTRG00000001789|UniProtKB=H2Q0T2	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF155	REGULATOR OF G-PROTEIN SIGNALING 18
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	HUMAN|HGNC=2514|UniProtKB=P35222	Catenin beta-1	IDA	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PANTR|Ensembl=ENSPTRG00000009878|UniProtKB=H2QEA0	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05916	Opioid prodynorphin pathway	P06002	G-protein	DAPPU|EnsemblGenome=DAPPUDRAFT_59367|UniProtKB=E9H7Z0	Guanine nucleotide-binding protein G(O) subunit alpha 1	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=4599|UniProtKB=Q14831	Metabotropic glutamate receptor 7	IDA	12351712	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	HUMAN|HGNC=2510|UniProtKB=P26232	Catenin alpha-2	TAS	1638632	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=94924|UniProtKB=P61168	D(2) dopamine receptor	IDA	2137198	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00021	FGF signaling pathway	P00646	RasGAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	IPI	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00021	FGF signaling pathway	P00645	Rac	DICDI|dictyBase=DDB_G0279605|UniProtKB=P34148	Rho-related protein racB	ISS	94124042	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01179	PKB	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00367	NFAT	MACMU|Ensembl=ENSMMUG00000021843|UniProtKB=F6RNI3	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00048	PI3 kinase pathway	P01192	p110	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IC	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00005	Angiogenesis	P00219	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00011	Blood coagulation	P00461	PAR-4	MACMU|Ensembl=ENSMMUG00000017253|UniProtKB=F7H9M8	Uncharacterized protein	ISS	4503639	gi	PTHR24232:SF22	PROTEINASE-ACTIVATED RECEPTOR 4
P00019	Endothelin signaling pathway	P00591	PLCbeta	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05915	Opioid proenkephalin pathway	P05994	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	XENTR|Xenbase=XB-GENE-481916|UniProtKB=F6YF14	Presenilin	ISS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00006	Apoptosis signaling pathway	P00297	NFkappaB	CHICK|Gene=REL|UniProtKB=P16236	Proto-oncogene c-Rel	ISS			PTHR24169:SF4	PROTO-ONCOGENE C-REL
P00012	Cadherin signaling pathway	P00474	Wnt	TAKRU|Ensembl=ENSTRUG00000007912|UniProtKB=H2T4W3	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF83	PROTEIN WNT
P00056	VEGF signaling pathway	P01414	PLC-gamma	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00035	Interferon-gamma signaling pathway	P00958	PIAS	MACMU|Ensembl=ENSMMUG00000011699|UniProtKB=F7HEF3	E3 SUMO-protein ligase PIAS1	ISS	8682149	PubMed	PTHR10782:SF11	E3 SUMO-PROTEIN LIGASE PIAS1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00019	Endothelin signaling pathway	P00580	ET-RA/B	PANTR|Ensembl=ENSPTRG00000016494|UniProtKB=H2QQ94	Endothelin receptor type A	ISS	91080923	PubMed	PTHR24243:SF31	ENDOTHELIN-1 RECEPTOR
P00029	Huntington disease	P00807	Actin	MOUSE|MGI=MGI=1913963|UniProtKB=P61161	Actin-related protein 2	ISS	10974003	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00025	Hedgehog signaling pathway	P00682	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	HUMAN|HGNC=8528|UniProtKB=P01178	Oxytocin-neurophysin 1	ISS	3768139	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00962	ELK	HUMAN|HGNC=3326|UniProtKB=P28324	ETS domain-containing protein Elk-4	IC	11846562	PubMed	PTHR11849:SF21	ETS DOMAIN-CONTAINING PROTEIN ELK-4
P02738	De novo purine biosynthesis	P02891	GDP kinase	MACMU|Ensembl=ENSMMUG00000021079|UniProtKB=F7GY40	Uncharacterized protein	ISS			PTHR43109:SF2	NUCLEOSIDE DIPHOSPHATE KINASE 7
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	CHICK|Ensembl=ENSGALG00000007509|UniProtKB=F1NM72	Uncharacterized protein	ISS	6309844	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00048	PI3 kinase pathway	P01185	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CAEBR|Gene=CBG05858|UniProtKB=A8X1H0	Protein CBR-EGL-19 (Fragment)	ISS	10514528	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00057	Wnt signaling pathway	P01427	Naked	PANTR|Ensembl=ENSPTRG00000016691|UniProtKB=H2QQK8	Uncharacterized protein	ISS	11356022	PubMed	PTHR22611:SF1	PROTEIN NAKED CUTICLE HOMOLOG 2
P00046	Oxidative stress response	P01129	JNK1/2	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	15531926	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00057	Wnt signaling pathway	P01438	PP2A	BOVIN|Ensembl=ENSBTAG00000009245|UniProtKB=Q0P594	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	176892	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P05915	Opioid proenkephalin pathway	P05994	G-protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02788	Xanthine and guanine salvage pathway	P03245	Guanine phosphoribosyl transferase	ORNAN|Ensembl=ENSOANG00000011689|UniProtKB=F7AT83	Uncharacterized protein	ISS			PTHR43340:SF6	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE
P00019	Endothelin signaling pathway	P00572	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IGI	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00047	PDGF signaling pathway	P01173	STAT	HUMAN|HGNC=11362|UniProtKB=P42224	Signal transducer and activator of transcription 1-alpha/beta	ISS	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00035	Interferon-gamma signaling pathway	P00954	Interferongamma	CANLF|Ensembl=ENSCAFG00000000408|UniProtKB=P42161	Interferon gamma	TAS	11929133	PubMed	PTHR11419:SF0	INTERFERON GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CHICK|Ensembl=ENSGALG00000009844|UniProtKB=P68034	Actin, alpha cardiac muscle 1	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01065	VAChT	DROME|FlyBase=FBgn0270928|UniProtKB=O17444	Vesicular acetylcholine transporter	IC			PTHR23506:SF13	VESICULAR ACETYLCHOLINE TRANSPORTER
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05925	beta-ARR1	DANRE|ZFIN=ZDB-GENE-060824-1|UniProtKB=C3PTE8	Beta-arrestin 1	ISS	11742073	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	IDA	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01142	p90RSK	PANTR|Ensembl=ENSPTRG00000000387|UniProtKB=H2PYE3	Ribosomal protein S6 kinase	ISS	2779569	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT1G59580|UniProtKB=Q39022	Mitogen-activated protein kinase 2	ISS	94177172	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00054	Toll receptor signaling pathway	P01358	ERK1	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00008	Axon guidance mediated by Slit/Robo	P00344	Netrin	MACMU|Ensembl=ENSMMUG00000008197|UniProtKB=F7H0F3	Uncharacterized protein	ISS			PTHR10574:SF28	NETRIN-G1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	RAT|RGD=620577|UniProtKB=Q62636	Ras-related protein Rap-1b	IDA	10476970	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4403|UniProtKB=P61952	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	IC			PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01332	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	HUMAN|HGNC=4407|UniProtKB=P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00006	Apoptosis signaling pathway	P00269	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02734	Chorismate biosynthesis	P02871	2-Deoxy-7-phosphoheptulonate synthase	ECOLI|EcoGene=EG10078|UniProtKB=P00888	Phospho-2-dehydro-3-deoxyheptonate aldolase, Tyr-sensitive	ISS			PTHR21225:SF10	PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, TYR-SENSITIVE
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00557	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04393	Ras Pathway	P04567	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04578	Rho	DAPPU|EnsemblGenome=DAPPUDRAFT_301996|UniProtKB=E9HL06	Putative uncharacterized protein	ISS	7798239	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00047	PDGF signaling pathway	P01149	MNK1/2	BOVIN|Gene=MKNK1|UniProtKB=Q58D94	MAP kinase-interacting serine/threonine-protein kinase 1	ISS	11575158	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00023	General transcription regulation	P00668	TFIIB	ANOGA|EnsemblGenome=AGAP009680|UniProtKB=Q7Q1Q4	AGAP009680-PA	ISS			PTHR12458:SF8	CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00148	Erb-B4 N-terminal fragment	HUMAN|HGNC=3432|UniProtKB=Q15303	Receptor tyrosine-protein kinase erbB-4	IDA	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P05731	GABA-B receptor II signaling	P05755	Gbeta	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MACMU|Ensembl=ENSMMUG00000001661|UniProtKB=F7GR69	Uncharacterized protein	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	RAT|RGD=1563860|UniProtKB=D3Z8E0	Ribosomal protein S6 kinase	ISS	2779569	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05918	p38 MAPK pathway	P06026	MEKK4	HUMAN|HGNC=6856|UniProtKB=Q9Y6R4	Mitogen-activated protein kinase kinase kinase 4	IDA	602425	OMIM	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P02738	De novo purine biosynthesis	P02902	ADP reductase	ANOGA|EnsemblGenome=AGAP006818|UniProtKB=Q7QIF4	AGAP006818-PA	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PANTR|Ensembl=ENSPTRG00000008770|UniProtKB=H2QC99	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF385	MYOSIN-2
P05915	Opioid proenkephalin pathway	P05987	peptide F	RAT|RGD=68946|UniProtKB=P04094	Proenkephalin-A	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P02738	De novo purine biosynthesis	P02909	GDP reductase	ANOGA|Gene=AgaP_AGAP010198|UniProtKB=Q5TNU6	Ribonucleoside-diphosphate reductase (Fragment)	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P05916	Opioid prodynorphin pathway	P06002	G-protein	CHICK|Ensembl=ENSGALG00000001334|UniProtKB=F1NLV4	Uncharacterized protein	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MOUSE|MGI=MGI=109246|UniProtKB=P97288	5-hydroxytryptamine receptor 4	IDA	12181435	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00046	Oxidative stress response	P01135	p38	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	TAS	8920915	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P06664	Gonadotropin-releasing hormone receptor pathway	P06768	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	RCA	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00093	Tip60	CANLF|Ensembl=ENSCAFG00000013299|UniProtKB=E2RE71	Histone acetyltransferase	ISS	11441186	PubMed	PTHR10615:SF124	HISTONE ACETYLTRANSFERASE KAT5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00057	Wnt signaling pathway	P01428	Frizzled	MONDO|Ensembl=ENSMODG00000011428|UniProtKB=F6RKF7	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF34	FRIZZLED-2
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	IDA	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MACMU|Ensembl=ENSMMUG00000005483|UniProtKB=F7G271	Uncharacterized protein	ISS	6755374	gi	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00964	p90RSK	MACMU|Ensembl=ENSMMUG00000002134|UniProtKB=F6UNV6	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	MACMU|Ensembl=ENSMMUG00000010173|UniProtKB=F7AGU8	Presenilin	ISS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	IXOSC|EnsemblGenome=ISCW009711|UniProtKB=B7Q3T6	THO complex subunit, putative	ISS	9740024	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DICDI|dictyBase=DDB_G0289811|UniProtKB=Q54GX7	Actin-10	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00021	FGF signaling pathway	P00636	FGFR1-4	RAT|RGD=2611|UniProtKB=F1LSG7	Fibroblast growth factor receptor	IGI	8089146	PubMed	PTHR24416:SF130	FIBROBLAST GROWTH FACTOR RECEPTOR 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00049	Parkinson disease	P01208	Hsp70	TRIVA|Gene=TVAG_044510|UniProtKB=A2EY23	Cytoplasmic heat shock protein 70, putative	IDA	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00049	Parkinson disease	P01230	Src kinase	XENTR|Xenbase=XB-GENE-6053489|UniProtKB=F6S8L5	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MONDO|Ensembl=ENSMODG00000001807|UniProtKB=F6Y7R9	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00949	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	95096035	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	RAT|RGD=1308834|UniProtKB=D4ADV8	Protein Dvl3	ISS	11212302	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01080	AChE	PANTR|Ensembl=ENSPTRG00000015593|UniProtKB=H2QNP1	Carboxylic ester hydrolase	ISS	87080761	PubMed	PTHR43918:SF5	CHOLINESTERASE
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	MACMU|Ensembl=ENSMMUG00000014627|UniProtKB=F7GNE4	Catenin beta-1	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MACMU|Ensembl=ENSMMUG00000014807|UniProtKB=F6W548	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00024	Glycolysis	P00675	Pyruvate kinase	ORYSJ|EnsemblGenome=OS10G0571200|UniProtKB=Q8S7N6	Pyruvate kinase	ISS	19225011	gi	PTHR11817:SF26	PLASTIDIAL PYRUVATE KINASE 3, CHLOROPLASTIC
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CHICK|Ensembl=ENSGALG00000006638|UniProtKB=R4GGL9	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	RAT|RGD=67366|UniProtKB=P50393	Cytosolic phospholipase A2	IEA	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00029	Huntington disease	P00790	beta-Tubulin	MOUSE|MGI=MGI=107813|UniProtKB=Q9ERD7	Tubulin beta-3 chain	TAS	12932731	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00019	Endothelin signaling pathway	P00589	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	NAS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00470	F-actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g234494|UniProtKB=A7RU31	Predicted protein	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00034	Integrin signalling pathway	P00927	Rac	ENTHI|EnsemblGenome=EHI_197840|UniProtKB=C4M8K6	Rho family GTPase	IGI	8649368	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	SCLS1|Gene=SS1G_08733|UniProtKB=A7ETS6	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00005	Angiogenesis	P00203	Erk	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	DANRE|ZFIN=ZDB-GENE-040805-1|UniProtKB=Q1LYG2	Uncharacterized protein	ISS			PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00034	Integrin signalling pathway	P00951	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00627	ERK1-2	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00048	PI3 kinase pathway	P01177	P110ACT	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01311	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	HUMAN|HGNC=4586|UniProtKB=Q13224	Glutamate receptor ionotropic, NMDA 2B	IC	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	PANTR|Ensembl=ENSPTRG00000008766|UniProtKB=H2QC97	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF504	MYOSIN-13
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_79607|UniProtKB=C3ZHN4	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00025	Hedgehog signaling pathway	P00682	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	ISS	91298951	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04393	Ras Pathway	P04541	p90RSK	HUMAN|HGNC=10430|UniProtKB=Q15418	Ribosomal protein S6 kinase alpha-1	ISS	6755374	gi	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00057	Wnt signaling pathway	P01457	GBeta	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P02772	Pyruvate metabolism	P03132	Pyruvate Kinase	XENTR|Xenbase=XB-GENE-485873|UniProtKB=F6W2Y6	Pyruvate kinase (Fragment)	ISS	8193145	PubMed	PTHR11817:SF15	PYRUVATE KINASE PKM
P04398	p53 pathway feedback loops 2	P04662	cyclin G	HUMAN|HGNC=1592|UniProtKB=P51959	Cyclin-G1	ISS			PTHR10177:SF59	CYCLIN-G1
P00018	EGF receptor signaling pathway	P00551	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00011	Blood coagulation	P00422	FIXa	MOUSE|MGI=MGI=88384|UniProtKB=P16294	Coagulation factor IX	ISS	119773	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P00049	Parkinson disease	P01242	Casein kinase I	DROME|FlyBase=FBgn0037325|UniProtKB=Q7JWT4	AT15039p	IDA	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00053	T cell activation	P01332	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00050	Plasminogen activating cascade	P01245	PAI-1	BOVIN|Ensembl=ENSBTAG00000014465|UniProtKB=P13909	Plasminogen activator inhibitor 1	IDA	129575	gi	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	CAEEL|WormBase=WBGene00004769|UniProtKB=P52166	Presenilin sel-12	IDA	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IDA	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00029	Huntington disease	P00778	NMDA receptor	MONDO|Ensembl=ENSMODG00000018204|UniProtKB=F6PGX6	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00018	EGF receptor signaling pathway	P00556	PLCgamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IGI	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IDA	12707323	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00048	PI3 kinase pathway	P01192	p110	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MACMU|Ensembl=ENSMMUG00000004253|UniProtKB=F6YQ28	Uncharacterized protein	ISS	98180967	PubMed	PTHR10201:SF165	COLLAGENASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00640	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8690|UniProtKB=Q9Y5E4	Protocadherin beta-5	IDA	8120095	PubMed	PTHR24028:SF90	PROTOCADHERIN BETA-5
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	PUCGT|EnsemblGenome=PGTG_11337|UniProtKB=E3KLJ3	Calmodulin	ISS	10487978	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00052	TGF-beta signaling pathway	P01290	TAB	PANTR|Ensembl=ENSPTRG00000014395|UniProtKB=H2QLQ4	Uncharacterized protein	ISS	10838074	PubMed	PTHR13832:SF533	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1
P00047	PDGF signaling pathway	P01161	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00011	Blood coagulation	P00458	GP IIIa	CANLF|Ensembl=ENSCAFG00000013735|UniProtKB=F1PPG5	Integrin beta	ISS	3487386	PubMed	PTHR10082:SF25	INTEGRIN BETA-3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00011	Blood coagulation	P00427	alpha2-macroglobulin	RAT|RGD=2004|UniProtKB=P06238	Alpha-2-macroglobulin	ISS	6978425	gi	PTHR11412:SF135	ALPHA-2-MACROGLOBULIN
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CHICK|Gene=CHRNG|UniProtKB=P02713	Acetylcholine receptor subunit gamma	IC	95224005	PubMed	PTHR18945:SF60	ACETYLCHOLINE RECEPTOR SUBUNIT GAMMA
P00057	Wnt signaling pathway	P01472	Histone deacetylase	DROME|FlyBase=FBgn0025825|UniProtKB=Q7KTS4	Histone deacetylase	IDA	10485845	PubMed	PTHR10625:SF132	HISTONE DEACETYLASE 3
P00012	Cadherin signaling pathway	P00474	Wnt	CHICK|Gene=WNT8C|UniProtKB=P51030	Protein Wnt-8c	IDA	8717036	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	RCA	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00019	Endothelin signaling pathway	P00566	ERK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	92020947	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00037	Ionotropic glutamate receptor pathway	P01026	KA	CHICK|Ensembl=ENSGALG00000015434|UniProtKB=F1NU20	Uncharacterized protein	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P04375	5HT3 type receptor mediated signaling pathway	P04425	K+ channel	PANTR|Ensembl=ENSPTRG00000020614|UniProtKB=H2QWR7	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00057	Wnt signaling pathway	P01433	SIAH-1	MOUSE|MGI=MGI=108063|UniProtKB=Q06985	E3 ubiquitin-protein ligase SIAH1B	ISS	11389839	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IDA	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	20010089	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00034	Integrin signalling pathway	P00941	Integrin alpha	MACMU|Ensembl=ENSMMUG00000011661|UniProtKB=F7HGW0	Uncharacterized protein	ISS	3487386	PubMed	PTHR23220:SF5	INTEGRIN ALPHA-8
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	ORNAN|Ensembl=ENSOANG00000000460|UniProtKB=F7F4W9	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	XENTR|Xenbase=XB-GENE-961282|UniProtKB=Q6DF43	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00239	Eph	RAT|RGD=2540|UniProtKB=P52796	Ephrin-B1	ISS			PTHR11304:SF17	EPHRIN-B1
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	MOUSE|MGI=MGI=1351338|UniProtKB=P97772	Metabotropic glutamate receptor 1	IC	12488551	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	8457205	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00034	Integrin signalling pathway	P00947	Laminin	DROME|FlyBase=FBgn0261800|UniProtKB=P11046	Laminin subunit beta-1	IPI	2538453	PubMed	PTHR10574:SF303	LAMININ SUBUNIT BETA-1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04393	Ras Pathway	P04552	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00036	Interleukin signaling pathway	P00976	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	ARATH|TAIR=AT1G13890|UniProtKB=Q9LMG8	Putative SNAP25 homologous protein SNAP30	IC			PTHR19305:SF7	SNAP25 HOMOLOGOUS PROTEIN SNAP30-RELATED
P00021	FGF signaling pathway	P00643	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00060	Ubiquitin proteasome pathway	P01491	E2	PLAF7|EnsemblGenome=PFC0255c|UniProtKB=O97241	Ubiquitin-conjugating enzyme E2, putative	ISS			PTHR43915:SF5	LD28904P
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IC	3045562	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P02775	Salvage pyrimidine ribonucleotides	P03156	CDP kinase	MOUSE|MGI=MGI=98904|UniProtKB=P52623	Uridine-cytidine kinase 1	ISS			PTHR10285:SF66	URIDINE-CYTIDINE KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	PANTR|Ensembl=ENSPTRG00000031262|UniProtKB=H2RAB4	Uncharacterized protein	ISS	9700720	PubMed	PTHR43893:SF8	D 1B  DOPAMINE RECEPTOR
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00034	Integrin signalling pathway	P00920	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04398	p53 pathway feedback loops 2	P04651	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IDA	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00006	Apoptosis signaling pathway	P00321	HSP70	PANTR|Ensembl=ENSPTRG00000000563|UniProtKB=H2PYQ3	Heat shock 70kDa protein 5 (Glucose-regulated protein, 78kDa)	ISS	10934466	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00931	Integrin beta	HUMAN|Ensembl=ENSG00000259753|UniProtKB=H3BM21	Integrin beta (Fragment)	IDA	5805339	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	XENTR|Xenbase=XB-GENE-957124|UniProtKB=F7BDN8	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00036	Interleukin signaling pathway	P00983	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DANRE|ZFIN=ZDB-GENE-030131-1229|UniProtKB=Q6DHS1	Actin, alpha 2, smooth muscle, aorta	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=4600|UniProtKB=O00222	Metabotropic glutamate receptor 8	IDA	12488551	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00048	PI3 kinase pathway	G01545	scl-1	CAEEL|WormBase=WBGene00008029|UniProtKB=Q18539	SCP-Like extracellular protein	ISS			PTHR10334:SF253	SCP-LIKE EXTRACELLULAR PROTEIN
P02736	Coenzyme A biosynthesis	P02886	Pantetheine-phosphate adenyltransferase	FUSNN|EnsemblGenome=FN0156|UniProtKB=Q8RGX1	Phosphopantetheine adenylyltransferase	ISS			PTHR21342:SF1	PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CANLF|Ensembl=ENSCAFG00000008756|UniProtKB=F2Z4N8	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00049	Parkinson disease	P01233	Elk-1	HUMAN|HGNC=3321|UniProtKB=P19419	ETS domain-containing protein Elk-1	IDA	10487205	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02920	dCTP deaminase	ECOLI|EcoGene=EG11372|UniProtKB=P68398	tRNA-specific adenosine deaminase	ISS			PTHR11079:SF149	TRNA-SPECIFIC ADENOSINE DEAMINASE
P00001	Adrenaline and noradrenaline biosynthesis	P00067	MAO	MOUSE|MGI=MGI=96916|UniProtKB=Q8BW75	Amine oxidase [flavin-containing] B	ISS	8602220	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ARATH|TAIR=AT5G09810|UniProtKB=P53492	Actin-7	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00006	Apoptosis signaling pathway	P00260	AKT	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	PANTR|Ensembl=ENSPTRG00000002178|UniProtKB=H2Q1F7	Adenylosuccinate synthetase isozyme 2	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00020	FAS signaling pathway	P00615	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	LEIMA|EnsemblGenome=LmjF.21.1860|UniProtKB=Q4QBZ6	Beta tubulin	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	TAS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00556	PLCgamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IGI	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	MACMU|Ensembl=ENSMMUG00000004329|UniProtKB=F6ZDV3	Excitatory amino acid transporter 2 isoform 1	ISS	94365697	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P00047	PDGF signaling pathway	P01161	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P02737	Cysteine biosynthesis	P02888	Serine acetyltransferase	LEPIN|EnsemblGenome=LA_1598|UniProtKB=Q8F5R9	Acetyltransferase	ISS			PTHR43300:SF5	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00551	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	PANTR|Ensembl=ENSPTRG00000023608|UniProtKB=H2QZZ2	Uncharacterized protein	ISS	14698601	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00021	FGF signaling pathway	P00626	Spry	BOVIN|Gene=SPRY1|UniProtKB=A5D992	Protein sprouty homolog 1	ISS	98117253	PubMed	PTHR12365:SF10	PROTEIN SPROUTY HOMOLOG 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04393	Ras Pathway	P04547	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	PANTR|Ensembl=ENSPTRG00000008174|UniProtKB=H2QB82	Chromosome 16 open reading frame 80	ISS			PTHR12458:SF8	CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20
P00037	Ionotropic glutamate receptor pathway	P01001	KA4	PANTR|Gene=GRIK4|UniProtKB=Q5IS46	Glutamate receptor ionotropic, kainate 4	ISS	12871085	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P02730	Asparagine and aspartate biosynthesis	P02853	Asparagine synthetase	RAT|RGD=2162|UniProtKB=P49088	Asparagine synthetase [glutamine-hydrolyzing]	ISS			PTHR11772:SF23	ASPARAGINE SYNTHETASE  GLUTAMINE-HYDROLYZING
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00748	Gbeta5L	MACMU|Ensembl=ENSMMUG00000017374|UniProtKB=F7H6T7	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P05913	Enkephalin release	P05974	G-Protein (i)	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	IC	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00030	Hypoxia response via HIF activation	P00824	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	RAT|RGD=621353|UniProtKB=P08082	Clathrin light chain B	ISS	9388255	PubMed	PTHR10639:SF2	CLATHRIN LIGHT CHAIN B
P00059	p53 pathway	P04615	MTA2	CANLF|Ensembl=ENSCAFG00000015809|UniProtKB=E2R655	Uncharacterized protein	ISS	11099047	PubMed	PTHR10865:SF4	METASTASIS-ASSOCIATED PROTEIN MTA2
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00057	Wnt signaling pathway	P01446	Calcineurin	MACMU|Ensembl=ENSMMUG00000014442|UniProtKB=F7BBG8	Serine/threonine-protein phosphatase	ISS	12091710	PubMed	PTHR11668:SF186	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT GAMMA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	CANLF|Ensembl=ENSCAFG00000018560|UniProtKB=F1PJ01	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF335	MYOSIN-11
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00996	STAT	HUMAN|HGNC=11362|UniProtKB=P42224	Signal transducer and activator of transcription 1-alpha/beta	IC	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00018	EGF receptor signaling pathway	P00552	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00035	Interferon-gamma signaling pathway	P00958	PIAS	BOVIN|Ensembl=ENSBTAG00000005564|UniProtKB=Q24JZ9	Protein inhibitor of activated STAT, 1	ISS	8682149	PubMed	PTHR10782:SF11	E3 SUMO-PROTEIN LIGASE PIAS1
P06959	CCKR signaling map	P07207	p60 SRC	HUMAN|HGNC=11283|UniProtKB=P12931	Proto-oncogene tyrosine-protein kinase Src	RCA		PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P02734	Chorismate biosynthesis	P02870	3-Phosphoshikimate-1-carboxyvinyl transferase	LEPIN|EnsemblGenome=LA_1258|UniProtKB=Q8F6P5	3-phosphoshikimate 1-carboxyvinyltransferase	ISS			PTHR21090:SF5	PENTAFUNCTIONAL AROM POLYPEPTIDE
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	PANTR|Ensembl=ENSPTRG00000007508|UniProtKB=H2QA58	Uncharacterized protein	ISS			PTHR11699:SF209	ALDEHYDE DEHYDROGENASE FAMILY 1 MEMBER A3
P00021	FGF signaling pathway	P00629	PP2A	CHICK|Ensembl=ENSGALG00000007565|UniProtKB=F1NS72	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B	ISS	12716901	PubMed	PTHR11871:SF1	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IDA	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00636	FGFR1-4	ORNAN|Ensembl=ENSOANG00000003252|UniProtKB=F6SM70	Fibroblast growth factor receptor	ISS	9989949	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P00057	Wnt signaling pathway	P01465	Ggamma	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DICDI|dictyBase=DDB_G0275023|UniProtKB=Q553U6	Putative actin-22	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00036	Interleukin signaling pathway	P00965	ERK	BOVIN|Ensembl=ENSBTAG00000001014|UniProtKB=A5PKJ4	Mitogen-activated protein kinase 7	ISS	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00046	Oxidative stress response	P01129	JNK1/2	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00013	Cell cycle	P00480	Proteasome	CANLF|Ensembl=ENSCAFG00000018382|UniProtKB=E2RJ26	Uncharacterized protein	ISS	97227943	PubMed	PTHR10678:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11
P00036	Interleukin signaling pathway	P00968	Ikk	MOUSE|MGI=MGI=1338071|UniProtKB=O88351	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00019	Endothelin signaling pathway	P00586	Gq	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IGI	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00019	Endothelin signaling pathway	P00577	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02768	Proline biosynthesis	P03112	Glutamate semialdehyde dehydrogenase	LEPIN|EnsemblGenome=LA_0854|UniProtKB=P94872	Gamma-glutamyl phosphate reductase	ISS			PTHR11063:SF8	DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE
P06587	Nicotine pharmacodynamics pathway	P06612	CHRNB3	HUMAN|HGNC=1963|UniProtKB=Q05901	Neuronal acetylcholine receptor subunit beta-3	TAS	15155845	PubMed	PTHR18945:SF75	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-3
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IDA	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00054	Toll receptor signaling pathway	P01351	TLR2,4,7	HUMAN|HGNC=11848|UniProtKB=O60603	Toll-like receptor 2	ISS			PTHR24365:SF17	TOLL-LIKE RECEPTOR 2
P00036	Interleukin signaling pathway	P00977	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	RCA	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	ORNAN|Ensembl=ENSOANG00000011750|UniProtKB=F6TWB9	Nucleoside diphosphate kinase	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P00021	FGF signaling pathway	P00636	FGFR1-4	CANLF|Ensembl=ENSCAFG00000005970|UniProtKB=E2R186	Fibroblast growth factor receptor	ISS	9989949	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DICDI|dictyBase=DDB_G0274383|UniProtKB=Q8MLZ3	cGMP-dependent 3',5'-cGMP phosphodiesterase A	IC	91298951	PubMed	PTHR45452:SF1	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01168	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	ISS	129387	gi	PTHR10048:SF14	PI-3 KINASE
P00029	Huntington disease	P00805	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01305	Calmodulin	DANRE|Ensembl=ENSDARG00000015050|UniProtKB=Q6PI52	Calmodulin	ISS	7514101	PubMed	PTHR23050:SF326	CALMODULIN
P00016	Cytoskeletal regulation by Rho GTPase	P00507	Rho	SCLS1|EnsemblGenome=SS1G_03867|UniProtKB=A7EEX6	RhoA protein	ISS	11973360	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	XENTR|Xenbase=XB-GENE-494200|UniProtKB=F7CS79	Uncharacterized protein	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010034|UniProtKB=F1PEE8	Uncharacterized protein	ISS	15226293	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00053	T cell activation	P01316	MHC-antigen	RAT|RGD=3477|UniProtKB=Q6MGB0	Protein RT1-DOa	ISS	73139	PubMed	PTHR19944:SF44	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DO ALPHA CHAIN
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00004	Alzheimer disease-presenilin pathway	P00128	Erb-B4	HUMAN|HGNC=3432|UniProtKB=Q15303	Receptor tyrosine-protein kinase erbB-4	IDA	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	CHICK|Ensembl=ENSGALG00000008898|UniProtKB=F1P2J9	Uncharacterized protein	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	IGI	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PLAF7|EnsemblGenome=PFL2215w|UniProtKB=Q8I4X0	Actin-1	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000009626|UniProtKB=F6ZYQ0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00383	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05731	GABA-B receptor II signaling	P05754	Ggamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00021	FGF signaling pathway	P00640	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00223	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01211	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00009	Axon guidance mediated by netrin	P00364	cdc42	ANOGA|EnsemblGenome=AGAP002440|UniProtKB=Q17031	Cdc42 homolog	ISS	9658176	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04398	p53 pathway feedback loops 2	P04651	Ras	BOVIN|Ensembl=ENSBTAG00000009778|UniProtKB=E1BMX0	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	CAEBR|Gene=CBG02059|UniProtKB=A8WRW6	Protein CBR-UNC-2 (Fragment)	ISS	14507926	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=8153|UniProtKB=P41143	Delta-type opioid receptor	IDA	11259487	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00029	Huntington disease	P00810	GAPDH	STRCO|Gene=CAC42138|UniProtKB=Q93J08	Glyceraldehyde-3-phosphate dehydrogenase	ISS			PTHR43148:SF2	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE C-RELATED
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00539	14-3-3	MOUSE|MGI=MGI=108109|UniProtKB=P61982	14-3-3 protein gamma	ISS	99360936	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00048	PI3 kinase pathway	P01189	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00056	VEGF signaling pathway	P01425	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=1930705|UniProtKB=P61264	Syntaxin-1B	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	BOVIN|Ensembl=ENSBTAG00000011579|UniProtKB=F1N5C5	Muscarinic acetylcholine receptor	ISS	12915051	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00006	Apoptosis signaling pathway	P00269	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	RAT|RGD=2850|UniProtKB=Q62758	5-hydroxytryptamine receptor 4	IDA	12181435	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MONDO|Ensembl=ENSMODG00000000771|UniProtKB=F6SSS3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	ISS	1319556	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95818|UniProtKB=Q61626	Glutamate receptor ionotropic, kainate 5	ISS	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00056	VEGF signaling pathway	P01413	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	11292874	PubMed	PTHR10048:SF14	PI-3 KINASE
P00049	Parkinson disease	P01211	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	IDA	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	TAS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04398	p53 pathway feedback loops 2	P04653	cdk2	PANTR|Ensembl=ENSPTRG00000005070|UniProtKB=H2Q670	Cyclin-dependent kinase 2	ISS	15660127	PubMed	PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P00013	Cell cycle	P00480	Proteasome	HUMAN|HGNC=9565|UniProtKB=P51665	26S proteasome non-ATPase regulatory subunit 7	ISS	95275316	PubMed	PTHR10540:SF7	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04376	5HT4 type receptor mediated signaling pathway	P04426	K+ channel	MOUSE|MGI=MGI=3521816|UniProtKB=Q3LS21	Potassium channel subfamily K member 9	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00634	MEKK1-5	RAT|RGD=1311192|UniProtKB=A0A0G2K3R1	Protein Map3k4	ISS	10207617	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	97449291	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00034	Integrin signalling pathway	P00944	Actin	XENTR|Xenbase=XB-GENE-491618|UniProtKB=Q6P378	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT2G42880|UniProtKB=Q9SJG9	Mitogen-activated protein kinase 20	ISS			PTHR24055:SF158	MITOGEN-ACTIVATED PROTEIN KINASE 20
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CAEEL|WormBase=WBGene00019064|UniProtKB=Q21000	MYOsin heavy chain structural genes	IC			PTHR13140:SF398	MYOSIN HEAVY CHAIN STRUCTURAL GENES
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	BOVIN|Ensembl=ENSBTAG00000025337|UniProtKB=F1MZX6	Uncharacterized protein	ISS			PTHR13140:SF504	MYOSIN-13
P00054	Toll receptor signaling pathway	P01352	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	XENTR|Xenbase=XB-GENE-491938|UniProtKB=Q6DIV8	Actin, alpha 1, skeletal muscle	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347736|UniProtKB=E9FRT1	Muscle-specific actin	ISS	14684598	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	PANTR|Ensembl=ENSPTRG00000016548|UniProtKB=H2QQC5	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	TAKRU|Ensembl=ENSTRUG00000003589|UniProtKB=H2S7P7	Uncharacterized protein	ISS	9700720	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-040426-2427|UniProtKB=F1Q6C0	Uncharacterized protein (Fragment)	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	SCHPO|PomBase=SPAC22F8.11|UniProtKB=P40977	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00029	Huntington disease	P00786	ARF	MONDO|Ensembl=ENSMODG00000024202|UniProtKB=F6S4U6	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF137	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 4D
P00012	Cadherin signaling pathway	P00474	Wnt	DANRE|ZFIN=ZDB-GENE-980526-352|UniProtKB=P47793	Protein Wnt-4a	IDA	11266476	PubMed	PTHR12027:SF103	PROTEIN WNT-4A
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01432	Beta-Catenin	CANLF|Ensembl=ENSCAFG00000005204|UniProtKB=B6V8E6	Catenin beta-1	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00015	Circadian clock system	P00501	Clock	CHICK|Gene=CLOCK|UniProtKB=Q8QGQ6	Circadian locomoter output cycles protein kaput	ISS			PTHR23042:SF2	CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	CAEEL|WormBase=WBGene00004921|UniProtKB=P34693	Synaptotagmin-1	ISS			PTHR10024:SF227	SYNAPTOTAGMIN 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04397	p53 pathway by glucose deprivation	P04641	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P02787	Vitamin B6 metabolism	P03244	Pyridoxal kinase	TRYB2|Gene=Tb927.6.2740|UniProtKB=D6XI07	Pyridoxal kinase	ISS	9274862	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P00018	EGF receptor signaling pathway	P00561	STAT	BOVIN|Ensembl=ENSBTAG00000006335|UniProtKB=F1MGJ4	Signal transducer and activator of transcription	ISS	94367369	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00053	T cell activation	P01332	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01212	p38 MAPK	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	NAS	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00053	T cell activation	P01331	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IDA	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00587	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00872	Rac	MACMU|Ensembl=ENSMMUG00000021075|UniProtKB=F7GY91	Uncharacterized protein	ISS	11756405	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05730	Endogenous cannabinoid signaling	P05746	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00046	Oxidative stress response	P01123	Bcl-2	HUMAN|HGNC=990|UniProtKB=P10415	Apoptosis regulator Bcl-2	TAS	11323415	PubMed	PTHR11256:SF11	APOPTOSIS REGULATOR BCL-2
P00034	Integrin signalling pathway	P00931	Integrin beta	MACMU|Ensembl=ENSMMUG00000014516|UniProtKB=F7GE04	Integrin beta	ISS	3487386	PubMed	PTHR10082:SF26	INTEGRIN BETA-5
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	88241036	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00898	FKHR	MOUSE|MGI=MGI=1890081|UniProtKB=Q9WVH4	Forkhead box protein O3	ISS	14775847	gi	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00053	T cell activation	P01312	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CANLF|Ensembl=ENSCAFG00000002617|UniProtKB=E2QUL1	Uncharacterized protein	ISS	14698601	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00049	Parkinson disease	P01233	Elk-1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	IDA	11151091	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	HUMAN|HGNC=3026|UniProtKB=P21918	D(1B) dopamine receptor	ISS	11861492	PubMed	PTHR43893:SF8	D 1B  DOPAMINE RECEPTOR
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	HUMAN|HGNC=9998|UniProtKB=P41220	Regulator of G-protein signaling 2	ISS	8756726	PubMed	PTHR10845:SF43	REGULATOR OF G-PROTEIN SIGNALING 2
P02727	Androgen/estrogene/progesterone biosynthesis	P02833	3beta-Hydroxysteroid dehydrogenase	MOUSE|MGI=MGI=109598|UniProtKB=O35469	3 beta-hydroxysteroid dehydrogenase/Delta 5--4-isomerase type 6	IPI	1924345	PubMed	PTHR10366:SF364	3 BETA-HYDROXYSTEROID DEHYDROGENASE/DELTA 5--4-ISOMERASE TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00848	Grb	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	9763606	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00021	FGF signaling pathway	P00624	14-3-3	HUMAN|HGNC=10773|UniProtKB=P31947	14-3-3 protein sigma	ISS	10407019	PubMed	PTHR18860:SF14	14-3-3 PROTEIN SIGMA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	TAKRU|Ensembl=ENSTRUG00000006363|UniProtKB=H2SSZ5	Uncharacterized protein	ISS			PTHR18945:SF535	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CHICK|Ensembl=ENSGALG00000027629|UniProtKB=Q5ZJ03	Guanine nucleotide-binding protein subunit gamma	IDA	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04398	p53 pathway feedback loops 2	P04665	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00635	FRS2	PANTR|Ensembl=ENSPTRG00000005207|UniProtKB=H2Q6G0	Fibroblast growth factor receptor substrate 2	ISS	10464310	PubMed	PTHR21258:SF40	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2
P06209	ALP23B signaling pathway	P06221	MED	DROME|FlyBase=FBgn0011655|UniProtKB=O62609	Mothers against decapentaplegic homolog	IEA	9395284	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P05916	Opioid prodynorphin pathway	P06002	G-protein	ANOGA|EnsemblGenome=AGAP005904|UniProtKB=Q7Q6E0	AGAP005904-PA	ISS	12488551	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00059	p53 pathway	P04623	CBP	ARATH|TAIR=AT1G79000|UniProtKB=Q9C5X9	Histone acetyltransferase HAC1	ISS	10664585	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	RCA	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IDA	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00018	EGF receptor signaling pathway	P00547	PP2A	PANTR|Ensembl=ENSPTRG00000006426|UniProtKB=H2Q8F8	Protein phosphatase 2, regulatory subunit B', epsilon isoform	ISS	11007767	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00056	VEGF signaling pathway	P01411	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00238	Ras	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00018	EGF receptor signaling pathway	P00545	JNK1-3	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=1305430|UniProtKB=F1M702	Protein Cdh18	ISS	8120095	PubMed	PTHR24027:SF106	CADHERIN-18
P00034	Integrin signalling pathway	P00912	Arp2/3	DROME|FlyBase=FBgn0065032|UniProtKB=Q9VX82	Actin-related protein 2/3 complex subunit 3	IPI	12473693	PubMed	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00059	p53 pathway	P01480	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	IGI	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=102705|UniProtKB=P63213	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00045	Notch signaling pathway	P01103	Next	CHICK|Ensembl=ENSGALG00000011696|UniProtKB=F1NMD6	Delta-like protein	IEP	9032014	PubMed	PTHR44097:SF1	PROTEIN JAGGED-2
P00047	PDGF signaling pathway	P01154	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P00005	Angiogenesis	P00238	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	ISS	12089061	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	G04702	p53	DANRE|ZFIN=ZDB-GENE-030814-2|UniProtKB=B0S576	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00059	p53 pathway	P04634	Cdc2	MONDO|Ensembl=ENSMODG00000017091|UniProtKB=F6V3X3	Uncharacterized protein	ISS			PTHR24056:SF334	CYCLIN-DEPENDENT KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DANRE|ZFIN=ZDB-GENE-030131-6503|UniProtKB=Q7ZUC5	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF297	PROTEIN KINASE C DELTA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	14570579	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	CANLF|Ensembl=ENSCAFG00000019633|UniProtKB=F1PDC7	Uncharacterized protein	ISS	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00053	T cell activation	P01336	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IGI	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00034	Integrin signalling pathway	P00916	Ras	MONDO|Ensembl=ENSMODG00000025248|UniProtKB=F7F5X1	Uncharacterized protein	ISS	99084794	PubMed	PTHR24070:SF186	GTPASE KRAS
P00052	TGF-beta signaling pathway	P01286	TGFbeta	RAT|RGD=621196|UniProtKB=O88959	Inhibin beta E chain	TAS	9759503	PubMed	PTHR11848:SF6	INHIBIN BETA E CHAIN
P05731	GABA-B receptor II signaling	P05755	Gbeta	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00059	p53 pathway	P01481	ATM/ATR	MACMU|Ensembl=ENSMMUG00000007927|UniProtKB=F7HT00	Uncharacterized protein	ISS	10196661	PubMed	PTHR11139:SF69	SERINE/THREONINE-PROTEIN KINASE ATR
P00049	Parkinson disease	P01238	14-3-3	HUMAN|HGNC=12855|UniProtKB=P63104	14-3-3 protein zeta/delta	ISS	92283271	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	XENTR|Ensembl=ENSXETG00000030841|UniProtKB=F7C5A3	Protein-serine/threonine kinase	RCA			PTHR24355:SF18	PROTEIN-SERINE/THREONINE KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CANLF|Ensembl=ENSCAFG00000004381|UniProtKB=J9JH96	Uncharacterized protein	ISS	8314195	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00018	EGF receptor signaling pathway	P00552	Ras	DICDI|dictyBase=DDB_G0293434|UniProtKB=P15064	Ras-like protein rasG	IGI	89128893	PubMed	PTHR24070:SF282	RAS GTPASE-RELATED
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01131	MKP5	MOUSE|MGI=MGI=2442191|UniProtKB=Q8BFV3	Dual specificity protein phosphatase 4	TAS			PTHR10159:SF111	DUAL SPECIFICITY PROTEIN PHOSPHATASE 4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00036	Interleukin signaling pathway	P00983	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P02763	Peptidoglycan biosynthesis	P03092	Phospho-N-acetylmuramoyl pentapeptide transferase	CHLTR|EnsemblGenome=CT_757|UniProtKB=O84762	Phospho-N-acetylmuramoyl-pentapeptide-transferase	ISS			PTHR22926:SF5	PHOSPHO-N-ACETYLMURAMOYL-PENTAPEPTIDE-TRANSFERASE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00030	Hypoxia response via HIF activation	P00821	Prolyl Hydroxylase	MACMU|Ensembl=ENSMMUG00000000040|UniProtKB=F7HPH6	Egl nine homolog 3	ISS	12912907	PubMed	PTHR12907:SF5	EGL NINE HOMOLOG 3
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	MOUSE|MGI=MGI=95810|UniProtKB=Q9Z2W9	Glutamate receptor 3	ISS	12941441	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00012	Cadherin signaling pathway	P00470	F-actin	PANTR|Ensembl=ENSPTRG00000011990|UniProtKB=H2QHZ9	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=8696|UniProtKB=Q9Y5H4	Protocadherin gamma-A1	IDA	8120095	PubMed	PTHR24028:SF108	PROTOCADHERIN GAMMA-A1
P02752	Mannose metabolism	P03017	Mannose 6-P isomerase	PANTR|Gene=MPI|UniProtKB=A5A6K3	Mannose-6-phosphate isomerase	ISS	9525984	PubMed	PTHR10309:SF0	MANNOSE-6-PHOSPHATE ISOMERASE
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00545	JNK1-3	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=1310389|UniProtKB=D3ZTF6	Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Predicted), isoform CRA_a	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00907	ERK	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS			PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P02787	Vitamin B6 metabolism	P03227	Phosphoserine transaminase	BACSU|EnsemblGenome=BSU10020|UniProtKB=P80862	Phosphoserine aminotransferase	ISS	9384377	PubMed	PTHR43247:SF2	PHOSPHOSERINE AMINOTRANSFERASE
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02763	Peptidoglycan biosynthesis	P03090	N-Acetylglucosaminyl transferase	STRCO|EnsemblGenome=CAB51993|UniProtKB=Q9ZBA5	UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase	ISS			PTHR21015:SF22	GLYCOSYLTRANSFERASE
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT4G36450|UniProtKB=O23236	Mitogen-activated protein kinase 14	IDA	10851062	PubMed	PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P00005	Angiogenesis	P00180	Dok-R	RAT|RGD=1310966|UniProtKB=D3ZHJ4	Protein Dok2	ISS			PTHR21258:SF14	DOCKING PROTEIN 2
P00012	Cadherin signaling pathway	P00470	F-actin	CAEBR|Gene=CBG23091|UniProtKB=A8Y4Q9	Protein CBR-ACT-2	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00059	p53 pathway	P04609	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	ISS	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P00012	Cadherin signaling pathway	P00477	GSK3beta	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04393	Ras Pathway	P04572	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	15737619	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P04379	Beta3 adrenergic receptor signaling pathway	P04449	Beta3	RAT|RGD=2061|UniProtKB=P26255	Beta-3 adrenergic receptor	ISS	11943840	PubMed	PTHR24248:SF3	BETA-3 ADRENERGIC RECEPTOR
P00036	Interleukin signaling pathway	P00983	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01172	c-Myc	BOVIN|Ensembl=ENSBTAG00000008409|UniProtKB=Q2HJ27	Myc proto-oncogene protein	ISS	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00030	Hypoxia response via HIF activation	P00823	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00054	Toll receptor signaling pathway	G01550	Gene trancription	CHICK|Gene=PTGS2|UniProtKB=P27607	Prostaglandin G/H synthase 2	ISS	1849272	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00376	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	TAS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00053	T cell activation	P01322	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00018	EGF receptor signaling pathway	P00543	ERK1-2	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	IGI	9836510	gi	PTHR24055:SF330	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	IDA	15313841	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00034	Integrin signalling pathway	P00924	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	DANRE|ZFIN=ZDB-GENE-020125-4|UniProtKB=F1QKT1	Uncharacterized protein	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	RAT|RGD=1305848|UniProtKB=P85970	Actin-related protein 2/3 complex subunit 2	ISS	17943202	gi	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=17175|UniProtKB=Q9P212	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	10934033	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00047	PDGF signaling pathway	P01143	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	13620175	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00034	Integrin signalling pathway	P00925	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	RAT|RGD=621516|UniProtKB=G3V6P8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P05918	p38 MAPK pathway	P06020	p38delta	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00048	PI3 kinase pathway	P01188	Gbetagamma	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00005	Angiogenesis	P00183	Shc	MOUSE|MGI=MGI=98296|UniProtKB=P98083	SHC-transforming protein 1	ISS	10982827	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	DROME|FlyBase=FBgn0004623|UniProtKB=P29829	Guanine nucleotide-binding protein subunit beta-2	ISS	11313908	PubMed	PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00012	Cadherin signaling pathway	P00468	Src	HUMAN|HGNC=11283|UniProtKB=P12931	Proto-oncogene tyrosine-protein kinase Src	ISS	8054685	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01236	Casein kinase II	ARATH|TAIR=AT2G23070|UniProtKB=O64816	Casein kinase II subunit alpha, chloroplastic	IDA	10617630	PubMed	PTHR24054:SF33	CASEIN KINASE II SUBUNIT ALPHA, CHLOROPLASTIC
P04398	p53 pathway feedback loops 2	P04665	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04397	p53 pathway by glucose deprivation	P04641	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01435	SWI/SNF	YEAST|SGD=S000005831|UniProtKB=Q08773	ISWI chromatin-remodeling complex ATPase ISW2	IDA	11532957	PubMed	PTHR10799:SF879	CHROMATIN-REMODELING COMPLEX ATPASE CHAIN ISWI
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	ANOGA|EnsemblGenome=AGAP006569|UniProtKB=Q7Q597	Acetyl-coenzyme A synthetase	ISS			PTHR24095:SF244	ACETYL-COENZYME A SYNTHETASE
P00023	General transcription regulation	P00662	TFIIA complex	CANLF|Ensembl=ENSCAFG00000016665|UniProtKB=E2R3G8	Transcription initiation factor IIA subunit 2	ISS			PTHR10966:SF0	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2
P02777	Succinate to proprionate conversion	P03163	Methylmalonyl-CoA decarboxylase	CAEBR|Gene=CBG14130|UniProtKB=A8XJD4	Protein CBR-PCCB-1	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P00011	Blood coagulation	P00456	HCII	MOUSE|MGI=MGI=96051|UniProtKB=P49182	Heparin cofactor 2	ISS	6680183	gi	PTHR11461:SF30	HEPARIN COFACTOR 2
P05731	GABA-B receptor II signaling	P05754	Ggamma	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	7925653	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P05918	p38 MAPK pathway	P06018	MNK1	MOUSE|MGI=MGI=894316|UniProtKB=O08605	MAP kinase-interacting serine/threonine-protein kinase 1	RCA	97299868	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00938	Cdc42	XENTR|Xenbase=XB-GENE-967585|UniProtKB=Q28BZ0	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00017	DNA replication	P00527	Histones	CAEBR|Gene=CBG16863|UniProtKB=A8XPY9	Histone H3	ISS	20448842	PubMed	PTHR11426:SF20	HISTONE H3-LIKE CENTROMERIC PROTEIN A
P00057	Wnt signaling pathway	P01444	Wnt	CANLF|Ensembl=ENSCAFG00000029321|UniProtKB=J9P5H0	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00048	PI3 kinase pathway	P01199	Galpha	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	IC	8836152	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00049	Parkinson disease	P01208	Hsp70	PANTR|Ensembl=ENSPTRG00000017290|UniProtKB=H2QRK8	Heat shock 70kDa protein 9 (Mortalin)	ISS	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	TAS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00048	PI3 kinase pathway	P01199	Galpha	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P06664	Gonadotropin-releasing hormone receptor pathway	P06850	PKCs(3)	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	RCA	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05913	Enkephalin release	P05974	G-Protein (i)	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04393	Ras Pathway	P04567	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00005	Angiogenesis	P00238	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	HUMAN|HGNC=14246|UniProtKB=Q9NPA2	Matrix metalloproteinase-25	TAS	12834808	PubMed	PTHR10201:SF142	MATRIX METALLOPROTEINASE-25
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	RAT|RGD=2246|UniProtKB=Q07652	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	14624853	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P02744	Fructose galactose metabolism	P02966	Hexokinase	HUMAN|HGNC=23302|UniProtKB=Q2TB90	Putative hexokinase HKDC1	RCA			PTHR19443:SF28	HEXOKINASE HKDC1-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BOVIN|Ensembl=ENSBTAG00000013990|UniProtKB=F1MN70	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00005	Angiogenesis	P00181	SHP2	MONDO|Ensembl=ENSMODG00000003120|UniProtKB=F6WVD2	Tyrosine-protein phosphatase non-receptor type	ISS	1382983	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00005	Angiogenesis	P00190	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	227170	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P02786	Vitamin B6 biosynthesis	P03225	1-Deoxyxylulose-5-phosphate synthase	STRCO|EnsemblGenome=CAD55365|UniProtKB=Q8CJP7	1-deoxy-D-xylulose-5-phosphate synthase 2	ISS			PTHR43322:SF6	1-DEOXY-D-XYLULOSE-5-PHOSPHATE SYNTHASE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Gene=ACTG2|UniProtKB=P63270	Actin, gamma-enteric smooth muscle	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	CHICK|Ensembl=ENSGALG00000004693|UniProtKB=Q5ZJI7	Uncharacterized protein	ISS	12473693	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P02772	Pyruvate metabolism	P03132	Pyruvate Kinase	CAEBR|Gene=CBG05956|UniProtKB=A8X188	Pyruvate kinase	ISS	17544584	gi	PTHR11817:SF27	PYRUVATE KINASE
P00010	B cell activation	P00398	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00038	JAK/STAT signaling pathway	P01027	STAT	HUMAN|HGNC=11365|UniProtKB=Q14765	Signal transducer and activator of transcription 4	ISS	12496413	PubMed	PTHR11801:SF19	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 4
P04393	Ras Pathway	P04542	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	9298898	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02751	Lysine biosynthesis	P03008	Dihydrodipicolinate synthase	STRCO|Gene=CAC37894|UniProtKB=Q93RY0	Putative dihydropicolinate synthase	ISS			PTHR12128:SF35	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	CHICK|Ensembl=ENSGALG00000017242|UniProtKB=Q9IA05	Frizzled-4	TAS	8717036	PubMed	PTHR11309:SF23	FRIZZLED-4
P00049	Parkinson disease	P01212	p38 MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	TAS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00015	Circadian clock system	G01499	per	RAT|RGD=727863|UniProtKB=Q8CHI5	Period circadian protein homolog 1	ISS	12782655	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P00036	Interleukin signaling pathway	P00973	PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	RCA	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00025	Hedgehog signaling pathway	P00691	CBP	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	PANTR|Ensembl=ENSPTRG00000011307|UniProtKB=H2QGV8	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF245	RAS-RELATED PROTEIN R-RAS
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000011838|UniProtKB=H2QHR7	Serine/threonine-protein kinase	ISS	12676944	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00019	Endothelin signaling pathway	P00566	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02788	Xanthine and guanine salvage pathway	P03249	Guanine deaminase	MOUSE|MGI=MGI=95678|UniProtKB=Q9R111	Guanine deaminase	ISS	7533042	gi	PTHR11271:SF6	GUANINE DEAMINASE
P00035	Interferon-gamma signaling pathway	P00952	Jak2	PANTR|Ensembl=ENSPTRG00000020744|UniProtKB=H2QWZ4	Tyrosine-protein kinase	ISS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00011	Blood coagulation	P00458	GP IIIa	HUMAN|Ensembl=ENSG00000259753|UniProtKB=H3BM21	Integrin beta (Fragment)	ISS	484963	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00023	General transcription regulation	P00662	TFIIA complex	BOVIN|Ensembl=ENSBTAG00000013652|UniProtKB=F1MII0	Uncharacterized protein	ISS	600519	OMIM	PTHR12694:SF7	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	PANTR|Ensembl=ENSPTRG00000006510|UniProtKB=H2Q8K1	Presenilin	ISS	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P00057	Wnt signaling pathway	P01448	CBP	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	IDA	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00006	Apoptosis signaling pathway	P00274	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	11251832	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00788	Calpain	HUMAN|HGNC=1480|UniProtKB=P20807	Calpain-3	IDA	11675509	PubMed	PTHR10183:SF329	CALPAIN-3
P00004	Alzheimer disease-presenilin pathway	P00113	Erb-B4 transmembrane fragment	ORNAN|Ensembl=ENSOANG00000007021|UniProtKB=F7GAV2	Receptor protein-tyrosine kinase	ISS	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00014	Cholesterol biosynthesis	P00499	Farnesyl-diphosphate farnesyltransferase	HUMAN|HGNC=3629|UniProtKB=P37268	Squalene synthase	ISS			PTHR11626:SF2	SQUALENE SYNTHASE
P00053	T cell activation	P01322	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	DROME|FlyBase=FBgn0015278|UniProtKB=Q7K3H0	LD28067p	ISS	96278830	PubMed	PTHR10048:SF64	LD28067P
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05730	Endogenous cannabinoid signaling	P05751	Galpha	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00898	FKHR	RAT|RGD=1309196|UniProtKB=D3ZBQ1	Forkhead box O3a (Predicted)	ISS	12048180	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00045	Notch signaling pathway	P01113	Pen-2	DANRE|ZFIN=ZDB-GENE-000330-9|UniProtKB=Q90ZE4	Presenilin-2	IEP	12424519	PubMed	PTHR10202:SF13	PRESENILIN-2
P04371	5-Hydroxytryptamine biosynthesis	P04400	Aromatic L-amino acid decarboxylase	CAEBR|Gene=CBG00668|UniProtKB=A8WNB9	Protein CBR-TDC-1	ISS			PTHR11999:SF70	MIP05841P
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	PANTR|Ensembl=ENSPTRG00000020039|UniProtKB=H2R9W1	Uncharacterized protein	ISS	92370677	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00047	PDGF signaling pathway	P01153	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04567	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00923	Arf1	DANRE|ZFIN=ZDB-GENE-040718-175|UniProtKB=Q6DGK1	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00005	Angiogenesis	P00238	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00034	Integrin signalling pathway	P00907	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	RAT|RGD=2732|UniProtKB=P22756	Glutamate receptor ionotropic, kainate 1	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	MOUSE|MGI=MGI=88275|UniProtKB=Q61301	Catenin alpha-2	TAS	1768802	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	IC	91056091	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P02743	Formyltetrahydroformate biosynthesis	P02953	Cobalamin dependent homocysteine transmethylase	ANOGA|Gene=AgaP_AGAP008537|UniProtKB=Q7PNI0	AGAP008537-PA (Fragment)	ISS			PTHR21091:SF123	FI01821P
P00018	EGF receptor signaling pathway	P00564	Rac	CHICK|Ensembl=ENSGALG00000002859|UniProtKB=F6UBD2	Uncharacterized protein	ISS	9252344	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	TAS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	MOUSE|MGI=MGI=95810|UniProtKB=Q9Z2W9	Glutamate receptor 3	IC	12871085	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00021	FGF signaling pathway	P00629	PP2A	ARATH|TAIR=AT5G28850|UniProtKB=Q5QIT3	Serine/threonine protein phosphatase 2A regulatory subunit B''beta	ISS			PTHR14095:SF0	SERINE/THREONINE PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B''ALPHA-RELATED
P00029	Huntington disease	P00776	c-Jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00543	ERK1-2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00897	SHIP2	CANLF|Ensembl=ENSCAFG00000005743|UniProtKB=F1PNY0	Uncharacterized protein	ISS	9824312	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00049	Parkinson disease	P01242	Casein kinase I	PANTR|Ensembl=ENSPTRG00000009796|UniProtKB=H2QE47	Casein kinase 1, delta	ISS	10617630	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00059	p53 pathway	P04609	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00786	ARF	BOVIN|Ensembl=ENSBTAG00000011883|UniProtKB=Q2YDM1	ADP-ribosylation factor-like protein 1	ISS	11752622	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	NEUCR|EnsemblGenome=EFNCRG00000006822|UniProtKB=P16929	Acetyl-coenzyme A synthetase	ISS			PTHR24095:SF14	ACETYL-COENZYME A SYNTHETASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	IC	2372396	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CHICK|Gene=ACTA2|UniProtKB=P08023	Actin, aortic smooth muscle	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	MONDO|Ensembl=ENSMODG00000008889|UniProtKB=F7BRY9	Serine/threonine-protein kinase receptor	ISS	11252892	PubMed	PTHR23255:SF57	ACTIVIN RECEPTOR TYPE-2B
P00005	Angiogenesis	P00223	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	HUMAN|HGNC=1389|UniProtKB=Q00975	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	14507926	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P02721	ATP synthesis	P02791	F1 alpha	CANLF|Ensembl=ENSCAFG00000017648|UniProtKB=E2RNG2	ATP synthase subunit alpha	ISS	11479684	PubMed	PTHR43089:SF3	ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CHICK|Ensembl=ENSGALG00000002098|UniProtKB=F1P0L4	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	YEAST|SGD=S000006125|UniProtKB=P29295	Casein kinase I homolog HRR25	IDA	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	IC	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00018	EGF receptor signaling pathway	P00556	PLCgamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IGI	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	EMENI|EnsemblGenome=CADANIAG00010170|UniProtKB=Q5B963	Uncharacterized protein	ISS			PTHR23073:SF13	26S PROTEASE REGULATORY SUBUNIT 7
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	IC	9009705	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00017	DNA replication	P00527	Histones	MACMU|Ensembl=ENSMMUG00000032409|UniProtKB=F6UJL2	Histone H3	ISS	12413958	PubMed	PTHR11426:SF179	HISTONE H3.3
P00001	Adrenaline and noradrenaline biosynthesis	P00066	DOPA decarb.	CAEBR|Gene=CBG08967|UniProtKB=A8X844	Protein CBR-BAS-1	ISS	7567987	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ARATH|TAIR=AT5G09810|UniProtKB=P53492	Actin-7	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00011	Blood coagulation	P00450	Tissue Factor	RAT|RGD=2587|UniProtKB=P42533	Tissue factor	ISS	6978823	gi	PTHR20859:SF22	TISSUE FACTOR
P00036	Interleukin signaling pathway	P00965	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	IC	9603989	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02747	Histidine biosynthesis	P02992	Imidazol glycerol phosphate synthase	BACSU|EnsemblGenome=BSU34890|UniProtKB=O34565	Imidazole glycerol phosphate synthase subunit HisH	ISS			PTHR42701:SF1	IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISH
P00036	Interleukin signaling pathway	P00966	mTOR	MACMU|Ensembl=ENSMMUG00000019325|UniProtKB=F6RVV5	Uncharacterized protein	ISS	8662507	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	MONDO|Ensembl=ENSMODG00000016960|UniProtKB=F6V5G0	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00036	Interleukin signaling pathway	P00983	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00545	JNK1-3	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00007	Axon guidance mediated by semaphorins	P00339	CRMP	BOVIN|Ensembl=ENSBTAG00000004292|UniProtKB=E1BER6	Uncharacterized protein	ISS	96424532	PubMed	PTHR11647:SF54	DIHYDROPYRIMIDINASE-RELATED PROTEIN 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02755	Methylmalonyl pathway	P03032	Methylmalonyl-CoA epimerase	MACMU|Ensembl=ENSMMUG00000008396|UniProtKB=F6VQY5	Uncharacterized protein	ISS			PTHR43048:SF3	METHYLMALONYL-COA EPIMERASE, MITOCHONDRIAL
P00049	Parkinson disease	P01238	14-3-3	HUMAN|HGNC=12855|UniProtKB=P63104	14-3-3 protein zeta/delta	ISS	12615066	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00015	Circadian clock system	P00505	Cry	RAT|RGD=620935|UniProtKB=Q923I8	Cryptochrome-2	IDA	11804325	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IC	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00019	Endothelin signaling pathway	P00591	PLCbeta	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00053	T cell activation	P01311	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IDA	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	DANRE|ZFIN=ZDB-GENE-070112-342|UniProtKB=A1L271	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P05731	GABA-B receptor II signaling	P05752	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04657	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00367	NFAT	HUMAN|HGNC=7776|UniProtKB=Q13469	Nuclear factor of activated T-cells, cytoplasmic 2	IDA	12015605	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02752	Mannose metabolism	P03018	Mannose 1-P guanylyl transferase	DEIRA|EnsemblGenome=DR_0710|UniProtKB=Q9RWF8	Mannose-1-phosphate guanyltransferase, putative	IEA	10567266	PubMed	PTHR43584:SF3	BIFUNCTIONAL PROTEIN GLMU
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	MACMU|Ensembl=ENSMMUG00000010173|UniProtKB=F7AGU8	Presenilin	ISS	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	PHYIT|EnsemblGenome=PITG_06376|UniProtKB=D0N4Q3	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta, putative	ISS	12081467	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00029	Huntington disease	P00807	Actin	CAEBR|Gene=CBG02167|UniProtKB=A8WS37	Protein CBG02167	ISS	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	PANTR|Ensembl=ENSPTRG00000017380|UniProtKB=H2RC76	Dihydropyrimidinase-like 3	ISS	3122041	gi	PTHR11647:SF57	DIHYDROPYRIMIDINASE-RELATED PROTEIN 3
P00049	Parkinson disease	P01238	14-3-3	CANLF|Ensembl=ENSCAFG00000031015|UniProtKB=J9P6N4	Uncharacterized protein	ISS	6756037	gi	PTHR18860:SF16	14-3-3 PROTEIN ETA
P02738	De novo purine biosynthesis	P02904	Guanylate kinase	MYCTU|EnsemblGenome=Rv1389|UniProtKB=P9WKE9	Guanylate kinase	ISS			PTHR23117:SF13	GUANYLATE KINASE
P00034	Integrin signalling pathway	P00944	Actin	MONBE|Gene=37852|UniProtKB=A9V489	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00626	Spry	HUMAN|HGNC=15533|UniProtKB=Q9C004	Protein sprouty homolog 4	ISS	22024232	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	PANTR|Ensembl=ENSPTRG00000012554|UniProtKB=H2QIU8	Receptor protein serine/threonine kinase	ISS			PTHR23255:SF58	ACTIVIN RECEPTOR TYPE-1C
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IDA	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04371	5-Hydroxytryptamine biosynthesis	P04399	Tryptophan hydroxylase	DANRE|ZFIN=ZDB-GENE-030317-1|UniProtKB=F1R1D3	Uncharacterized protein	ISS	14597720	PubMed	PTHR11473:SF23	TRYPTOPHAN 5-HYDROXYLASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	HUMAN|HGNC=10000|UniProtKB=P49798	Regulator of G-protein signaling 4	ISS	9774420	PubMed	PTHR10845:SF184	REGULATOR OF G-PROTEIN SIGNALING 4
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000047719|UniProtKB=Q95136	D(1A) dopamine receptor	IDA			PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04395	Vasopressin synthesis	P04593	Glycopeptide	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	IC	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	TAS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P02781	Threonine biosynthesis	P03190	Threonine synthase	STRCO|Gene=CAC33919|UniProtKB=Q9ADB3	Threonine synthase	ISS			PTHR10314:SF5	THREONINE SYNTHASE 1, CHLOROPLASTIC
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	MACMU|Ensembl=ENSMMUG00000010184|UniProtKB=F6SR09	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05934	ELK1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	RCA	11151091	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00055	Transcription regulation by bZIP transcription factor	P01389	TTF2	MOUSE|MGI=MGI=1921294|UniProtKB=Q5NC05	Transcription termination factor 2	RCA			PTHR10799:SF834	TRANSCRIPTION TERMINATION FACTOR 2
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	PANTR|Ensembl=ENSPTRG00000014976|UniProtKB=H2R892	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MACMU|Ensembl=ENSMMUG00000011267|UniProtKB=F6WNY5	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF43	GROWTH/DIFFERENTIATION FACTOR 6
P06664	Gonadotropin-releasing hormone receptor pathway	P06834	MAP3Ks	MOUSE|MGI=MGI=1346875|UniProtKB=O08648	Mitogen-activated protein kinase kinase kinase 4	RCA	11730323	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00029	Huntington disease	P00790	beta-Tubulin	PANTR|Gene=TUBB8|UniProtKB=Q8WP14	Tubulin beta-8 chain	TAS	9454836	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IDA	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05731	GABA-B receptor II signaling	P05755	Gbeta	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00057	Wnt signaling pathway	P01448	CBP	HUMAN|HGNC=3373|UniProtKB=Q09472	Histone acetyltransferase p300	IDA	10769018	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	ORNAN|Ensembl=ENSOANG00000002406|UniProtKB=F7BAS2	Uncharacterized protein	ISS	11259591	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00059	p53 pathway	P04633	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01188	Gbetagamma	ANOGA|EnsemblGenome=AGAP005911|UniProtKB=Q7Q6D4	AGAP005911-PA	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00021	FGF signaling pathway	P00639	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	8264585	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P02775	Salvage pyrimidine ribonucleotides	P03152	Uridine phosphorylase	ANOGA|EnsemblGenome=AGAP000188|UniProtKB=Q7PFX7	Uridine phosphorylase	ISS			PTHR43691:SF3	URIDINE PHOSPHORYLASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00005	Angiogenesis	P00210	eNOS	BOVIN|Gene=NOS3|UniProtKB=P29473	Nitric oxide synthase, endothelial	ISS	93055452	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	MOUSE|MGI=MGI=94925|UniProtKB=P30728	D(3) dopamine receptor	ISS	2137198	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00012	Cadherin signaling pathway	P00470	F-actin	YARLI|EnsemblGenome=YALI0_D08272g|UniProtKB=Q9UVF3	Actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00056	VEGF signaling pathway	P01425	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	10395542	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	CANLF|Ensembl=ENSCAFG00000005415|UniProtKB=F1PQM2	Uncharacterized protein	ISS	4757780	gi	PTHR11792:SF22	BETA-ARRESTIN-1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00036	Interleukin signaling pathway	P00973	PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IGI	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	HUMAN|HGNC=27309|UniProtKB=Q86XF0	Dihydrofolate reductase, mitochondrial	ISS			PTHR22778:SF26	DIHYDROFOLATE REDUCTASE, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	10553940	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00029	Huntington disease	P00775	Rac	MACMU|Ensembl=ENSMMUG00000021075|UniProtKB=F7GY91	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00004	Alzheimer disease-presenilin pathway	P00127	APP	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00029	Huntington disease	P00770	N-CoR	MACMU|Ensembl=ENSMMUG00000023107|UniProtKB=F7GMR8	Uncharacterized protein	ISS	11112321	PubMed	PTHR13992:SF21	NUCLEAR RECEPTOR COREPRESSOR 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	RCA	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00898	FKHR	MACMU|Ensembl=ENSMMUG00000020369|UniProtKB=F6UMX8	Uncharacterized protein	ISS	14775847	gi	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00021	FGF signaling pathway	P00624	14-3-3	ORNAN|Ensembl=ENSOANG00000007305|UniProtKB=F6XW91	Uncharacterized protein	ISS	92362864	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P05918	p38 MAPK pathway	P06021	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12960248	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00019	Endothelin signaling pathway	P00572	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	CAEBR|Gene=CBG12686|UniProtKB=A8XGC4	Protein CBR-ACR-11	ISS	11404397	PubMed	PTHR18945:SF436	ACETYLCHOLINE RECEPTOR
P00054	Toll receptor signaling pathway	P01376	Uev1A	PANTR|Ensembl=ENSPTRG00000013615|UniProtKB=H2QKK2	Ubiquitin-conjugating enzyme E2 variant 1	ISS			PTHR43915:SF2	UBIQUITIN-CONJUGATING ENZYME E2 VARIANT 1
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00005	Angiogenesis	P00256	PLC-gamma	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00021	FGF signaling pathway	P00645	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00023	General transcription regulation	P00668	TFIIB	PANTR|Ensembl=ENSPTRG00000020163|UniProtKB=H2QW11	BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like	ISS			PTHR11618:SF5	TRANSCRIPTION FACTOR IIIB 50 KDA SUBUNIT
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	ISS	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00018	EGF receptor signaling pathway	P00543	ERK1-2	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	YEAST|SGD=S000004795|UniProtKB=P39926	Protein SSO2	IC			PTHR19957:SF41	SYNTAXIN-1A
P05916	Opioid prodynorphin pathway	P06002	G-protein	ORNAN|Ensembl=ENSOANG00000003489|UniProtKB=F7FSE3	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IC	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IGI	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	MYCTU|EnsemblGenome=Rv1981c|UniProtKB=P9WH73	Ribonucleoside-diphosphate reductase subunit beta nrdF1	ISS			PTHR23409:SF32	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT BETA
P00048	PI3 kinase pathway	P01196	PDK1	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	11256888	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IC	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00896	Insulin IGF	CANLF|Ensembl=ENSCAFG00000010092|UniProtKB=P01321	Insulin	ISS			PTHR11454:SF9	INSULIN-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00019	Endothelin signaling pathway	P00572	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	4757952	gi	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2050|UniProtKB=P29276	Adenosine receptor A2b	IDA			PTHR24246:SF18	ADENOSINE RECEPTOR A2B
P00034	Integrin signalling pathway	P00920	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04398	p53 pathway feedback loops 2	P04664	cyclin E	MOUSE|MGI=MGI=88316|UniProtKB=Q61457	G1/S-specific cyclin-E1	ISS	15705141	gi	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00048	PI3 kinase pathway	P01185	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04393	Ras Pathway	P04544	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	12748278	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	RAT|RGD=2025|UniProtKB=P68136	Actin, alpha skeletal muscle	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00543	ERK1-2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01159	SOS	CHICK|Ensembl=ENSGALG00000013224|UniProtKB=F1NMA4	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00034	Integrin signalling pathway	P00947	Laminin	HUMAN|HGNC=6484|UniProtKB=Q16363	Laminin subunit alpha-4	IPI	2538453	PubMed	PTHR44537:SF1	LAMININ SUBUNIT ALPHA-4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00018	EGF receptor signaling pathway	P00549	EGF	MACMU|Ensembl=ENSMMUG00000003280|UniProtKB=F7FK53	Proheparin-binding EGF-like growth factor	ISS	12882762	PubMed	PTHR10740:SF4	PROHEPARIN-BINDING EGF-LIKE GROWTH FACTOR
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00036	Interleukin signaling pathway	P00983	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00036	Interleukin signaling pathway	P00996	STAT	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	IC	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	CANLF|Gene=DRD2|UniProtKB=Q9GJU1	D(2) dopamine receptor	ISS	2137198	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	XENTR|Xenbase=XB-GENE-494200|UniProtKB=F7CS79	Uncharacterized protein	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	ORNAN|Ensembl=ENSOANG00000011750|UniProtKB=F6TWB9	Nucleoside diphosphate kinase	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P00012	Cadherin signaling pathway	P00474	Wnt	MACMU|Ensembl=ENSMMUG00000002439|UniProtKB=F6PJN8	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P00018	EGF receptor signaling pathway	P00558	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IGI	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	HUMAN|HGNC=1402|UniProtKB=Q08289	Voltage-dependent L-type calcium channel subunit beta-2	IC	20088160	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00048	PI3 kinase pathway	P01192	p110	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01149	MNK1/2	MOUSE|MGI=MGI=894316|UniProtKB=O08605	MAP kinase-interacting serine/threonine-protein kinase 1	ISS	11575158	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00590	IP3 R	ANOGA|EnsemblGenome=AGAP006475|UniProtKB=Q5TQX0	AGAP006475-PA	ISS	4262086	gi	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	BOVIN|Ensembl=ENSBTAG00000009245|UniProtKB=Q0P594	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00046	Oxidative stress response	P01135	p38	DANRE|ZFIN=ZDB-GENE-990415-257|UniProtKB=O42376	Mitogen-activated protein kinase 12	TAS	11274345	PubMed	PTHR24055:SF339	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00034	Integrin signalling pathway	P00924	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	HUMAN|HGNC=7576|UniProtKB=P13533	Myosin-6	ISS	89264452	PubMed	PTHR13140:SF721	MYOSIN-6
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	MOUSE|MGI=MGI=1916831|UniProtKB=Q9EQT3	Rho-related GTP-binding protein RhoU	ISS			PTHR24072:SF148	RHO-RELATED GTP-BINDING PROTEIN RHOU
P00024	Glycolysis	P00674	Phosphoglucose isomerase	RAT|RGD=2727|UniProtKB=Q6P6V0	Glucose-6-phosphate isomerase	RCA			PTHR11469:SF4	GLUCOSE-6-PHOSPHATE ISOMERASE
P04393	Ras Pathway	P04541	p90RSK	HUMAN|HGNC=10431|UniProtKB=Q15349	Ribosomal protein S6 kinase alpha-2	IDA	6755374	gi	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00049	Parkinson disease	P01228	DAT	RAT|RGD=3715|UniProtKB=P23977	Sodium-dependent dopamine transporter	TAS	92107910	PubMed	PTHR11616:SF38	SODIUM-DEPENDENT DOPAMINE TRANSPORTER
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04558	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	IDA	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00053	T cell activation	P01321	SLP-76	MOUSE|MGI=MGI=1321402|UniProtKB=Q60787	Lymphocyte cytosolic protein 2	IGI	9665884	PubMed	PTHR14098:SF1	LYMPHOCYTE CYTOSOLIC PROTEIN 2
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	MOUSE|MGI=MGI=102891|UniProtKB=P51829	Adenylate cyclase type 7	IC	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MONDO|Ensembl=ENSMODG00000004799|UniProtKB=F6VM87	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00023	General transcription regulation	P00660	RNA Polymerase II	SCHPO|PomBase=SPCC1442.10c|UniProtKB=P37382	DNA-directed RNA polymerase II subunit RPB3	ISS	2187864	PubMed	PTHR11800:SF2	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEEL|WormBase=WBGene00004033|UniProtKB=P90980	Protein kinase C-like 2	ISS	2837282	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P04393	Ras Pathway	P04552	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MACMU|Ensembl=ENSMMUG00000010987|UniProtKB=F7GCX9	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DROME|FlyBase=FBgn0001105|UniProtKB=P26308	Guanine nucleotide-binding protein subunit beta-1	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00559	MEK1-2	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00053	T cell activation	P01306	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00018	EGF receptor signaling pathway	P00554	Shc	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	ISS	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00552	Ras	MACMU|Ensembl=ENSMMUG00000007756|UniProtKB=F7BXD0	Ras-related protein M-Ras	ISS			PTHR24070:SF268	RAS-RELATED PROTEIN M-RAS
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IGI	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00053	T cell activation	P01294	NFAT	BOVIN|Ensembl=ENSBTAG00000018270|UniProtKB=F1MGR9	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	IDA	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MOUSE|MGI=MGI=1339713|UniProtKB=Q5SX39	Myosin-4	IEP	10938134	PubMed	PTHR13140:SF657	MYOSIN-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT1G10210|UniProtKB=Q39021	Mitogen-activated protein kinase 1	ISS	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00036	Interleukin signaling pathway	P00965	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	IC	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01167	Ets	ORNAN|Ensembl=ENSOANG00000012104|UniProtKB=F7FH70	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00633	Ras	CAEBR|Gene=CBG06092|UniProtKB=A8X0X5	Protein CBR-LET-60	ISS	12024031	PubMed	PTHR24070:SF385	GTPASE HRAS
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00005	Angiogenesis	P00256	PLC-gamma	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01206	14-3-3	CAEEL|WormBase=WBGene00001502|UniProtKB=Q20655	14-3-3-like protein 2	ISS	10407019	PubMed	PTHR18860:SF13	14-3-3 PROTEIN ZETA
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	PANTR|Ensembl=ENSPTRG00000010183|UniProtKB=H2R6J7	Uncharacterized protein	ISS			PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P00048	PI3 kinase pathway	P01192	p110	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01177	P110ACT	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00269	MAPK	ORYSJ|EnsemblGenome=OS06G0154500|UniProtKB=Q84UI5	Mitogen-activated protein kinase 1	ISS	20055759	PubMed	PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P00059	p53 pathway	P01483	Mdm2	RAT|RGD=1309306|UniProtKB=Q5XIN1	Protein Mdm4	ISS			PTHR13844:SF20	PROTEIN MDM4
P00060	Ubiquitin proteasome pathway	P01490	E3	YEAST|SGD=S000003797|UniProtKB=P40985	Probable E3 ubiquitin-protein ligase HUL4	ISS			PTHR11254:SF354	HECT AND RCC DOMAIN E3 UBIQUITIN LIGASE
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00828	Galphai	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000017612|UniProtKB=C7G3N0	Glutamate receptor, metabotropic 6	ISS	9407094	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	PSEAE|EnsemblGenome=PA0296|UniProtKB=Q9I6J5	Probable glutamine synthetase	ISS			PTHR43785:SF1	TYPE-1 GLUTAMINE SYNTHETASE 2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00029	Huntington disease	P00776	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	P17325	SPACC	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00021	FGF signaling pathway	P00624	14-3-3	CHICK|Ensembl=ENSGALG00000004143|UniProtKB=Q5ZLQ6	14-3-3 protein beta/alpha	ISS	12618428	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	P01471	alpha-catenin	CANLF|Ensembl=ENSCAFG00000001315|UniProtKB=E2R9S7	Uncharacterized protein	ISS	1904011	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00006	Apoptosis signaling pathway	P00310	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IDA	14526383	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_127490|UniProtKB=C3XYC5	Putative uncharacterized protein	IDA	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	MOUSE|MGI=MGI=99673|UniProtKB=P84309	Adenylate cyclase type 5	ISS	93156838	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MACMU|Ensembl=ENSMMUG00000009341|UniProtKB=F6UA54	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P06587	Nicotine pharmacodynamics pathway	P06601	FLNA	HUMAN|HGNC=3754|UniProtKB=P21333	Filamin-A	IDA	9722563	PubMed	PTHR43998:SF6	FILAMIN-A
P00036	Interleukin signaling pathway	P00990	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CANLF|Ensembl=ENSCAFG00000002617|UniProtKB=E2QUL1	Uncharacterized protein	ISS	11554549	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00010	B cell activation	P00398	IP3R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00048	PI3 kinase pathway	P01192	p110	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00239	Eph	MOUSE|MGI=MGI=105097|UniProtKB=P52800	Ephrin-B2	ISS	9990854	PubMed	PTHR11304:SF18	EPHRIN-B2
P00029	Huntington disease	P00798	Clathrin	MOUSE|MGI=MGI=1921575|UniProtKB=Q6IRU5	Clathrin light chain B	ISS	11889126	PubMed	PTHR10639:SF2	CLATHRIN LIGHT CHAIN B
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000020224|UniProtKB=H2Q9G3	Mitogen-activated protein kinase 6	ISS	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P05913	Enkephalin release	P05974	G-Protein (i)	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00025	Hedgehog signaling pathway	P00693	Ubiquitin ligase	CHICK|Ensembl=ENSGALG00000016045|UniProtKB=F1P0U1	Uncharacterized protein	ISS			PTHR11254:SF402	E3 UBIQUITIN-PROTEIN LIGASE UBR5
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ORNAN|Ensembl=ENSOANG00000007716|UniProtKB=F6UDX9	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02916	dTMP kinase	HUMAN|HGNC=3061|UniProtKB=P23919	Thymidylate kinase	ISS			PTHR10344:SF1	THYMIDYLATE KINASE
P00034	Integrin signalling pathway	P00906	Rap1	RAT|RGD=620577|UniProtKB=Q62636	Ras-related protein Rap-1b	IPI	1904317	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00006	Apoptosis signaling pathway	P00260	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	CANLF|Ensembl=ENSCAFG00000015905|UniProtKB=E2QUH6	Uncharacterized protein	ISS	4757780	gi	PTHR11792:SF20	BETA-ARRESTIN-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	PANTR|Ensembl=ENSPTRG00000023608|UniProtKB=H2QZZ2	Uncharacterized protein	ISS	14698601	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00046	Oxidative stress response	P01131	MKP5	BOVIN|Ensembl=ENSBTAG00000008319|UniProtKB=F1MEZ2	Dual specificity protein phosphatase	ISS			PTHR10159:SF388	DUAL SPECIFICITY PROTEIN PHOSPHATASE 9
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PHYPA|Gene=PHYPADRAFT_109052|UniProtKB=A9TZ58	Actin 5	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00021	FGF signaling pathway	P00648	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=69319|UniProtKB=P54313	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P02775	Salvage pyrimidine ribonucleotides	P03150	Uridine kinase	MACMU|Ensembl=ENSMMUG00000015551|UniProtKB=F6RFS7	Uridine-cytidine kinase	ISS			PTHR10285:SF68	URIDINE-CYTIDINE KINASE-LIKE 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00551	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	IGI	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05915	Opioid proenkephalin pathway	P05994	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MOUSE|MGI=MGI=87917|UniProtKB=Q01341	Adenylate cyclase type 6	IGI	2491850	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00018	EGF receptor signaling pathway	P00558	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	XENTR|Xenbase=XB-GENE-6469705|UniProtKB=Q6P8G3	Actin, alpha sarcomeric/skeletal	ISS	10974003	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00238	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00036	Interleukin signaling pathway	P00990	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000040329|UniProtKB=F1MMU1	Uncharacterized protein	ISS	12441358	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=628675|UniProtKB=Q9Z2A6	Mitogen-activated protein kinase 15	TAS	10851062	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00048	PI3 kinase pathway	P01177	P110ACT	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	PANTR|Ensembl=ENSPTRG00000014365|UniProtKB=H2R0C8	Casein kinase 1, epsilon	ISS	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P05999	provasopressin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00004	Alzheimer disease-presenilin pathway	P00128	Erb-B4	MONDO|Ensembl=ENSMODG00000015755|UniProtKB=F6ZSZ9	Uncharacterized protein (Fragment)	ISS	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00047	PDGF signaling pathway	P01146	Ikk	PANTR|Ensembl=ENSPTRG00000020202|UniProtKB=H2QW34	Uncharacterized protein	RCA			PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P04393	Ras Pathway	P04542	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00141	Membrane metalloprotease	HUMAN|HGNC=7172|UniProtKB=Q9Y5R2	Matrix metalloproteinase-24	RCA			PTHR10201:SF138	MATRIX METALLOPROTEINASE-24
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DROME|FlyBase=FBgn0000489|UniProtKB=P16912	Protein kinase DC2	IC	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00008	Axon guidance mediated by Slit/Robo	P00342	Slit	XENTR|Xenbase=XB-GENE-1004410|UniProtKB=F7DQ42	Uncharacterized protein (Fragment)	ISS			PTHR24373:SF107	SLIT HOMOLOG 2 PROTEIN
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ARATH|TAIR=AT2G42090|UniProtKB=P93738	Putative actin-9	ISS	14684598	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P02749	Leucine biosynthesis	P03002	Isopropylmalate isomerase	DEIRA|EnsemblGenome=DR_1610|UniProtKB=Q9RTY9	3-isopropylmalate dehydratase large subunit 1	ISS			PTHR43822:SF2	HOMOACONITASE, MITOCHONDRIAL
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IDA	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IDA	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	TRYB2|Gene=TB927.1.2330|UniProtKB=Q4GYY6	Beta tubulin	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT1G10210|UniProtKB=Q39021	Mitogen-activated protein kinase 1	IDA	94177172	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P05731	GABA-B receptor II signaling	P05755	Gbeta	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P02748	Isoleucine biosynthesis	P02998	Dihydroxyacid dehydratase	THEMA|EnsemblGenome=TM_0551|UniProtKB=Q9WZ21	Dihydroxy-acid dehydratase	ISS			PTHR43661:SF3	DIHYDROXY-ACID DEHYDRATASE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	RAT|RGD=61915|UniProtKB=Q63635	Syntaxin-6	ISS	10839363	PubMed	PTHR19957:SF104	SYNTAXIN-6
P00004	Alzheimer disease-presenilin pathway	P00136	Abeta	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00052	TGF-beta signaling pathway	G01548	I-SMAD	XENTR|Xenbase=XB-GENE-481307|UniProtKB=F6S4W2	Mothers against decapentaplegic homolog	ISS	9335505	PubMed	PTHR13703:SF28	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 6
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	RAT|RGD=2522|UniProtKB=P30729	D(4) dopamine receptor	IDA	2137198	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P02738	De novo purine biosynthesis	P02894	IMP cyclohydrolase	BACSU|EnsemblGenome=BSU06520|UniProtKB=P12048	Bifunctional purine biosynthesis protein PurH	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P04393	Ras Pathway	P04548	ATF2	PANTR|Ensembl=ENSPTRG00000012660|UniProtKB=H2QJ07	Activating transcription factor 2	ISS	11390664	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00024	Glycolysis	P00677	Hexokinase	HUMAN|HGNC=4922|UniProtKB=P19367	Hexokinase-1	ISS	11835228	PubMed	PTHR19443:SF10	HEXOKINASE-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06835	Follistatin	MOUSE|MGI=MGI=95586|UniProtKB=P47931	Follistatin	RCA			PTHR10913:SF6	FOLLISTATIN
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01292	RSmads	RAT|RGD=3030|UniProtKB=P97588	Mothers against decapentaplegic homolog 1	TAS	12736218	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	RAT|RGD=70487|UniProtKB=Q9WU82	Catenin beta-1	IDA	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	MOUSE|MGI=MGI=1351342|UniProtKB=Q3UVX5	Metabotropic glutamate receptor 5	ISS	8314195	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00021	FGF signaling pathway	P00629	PP2A	BOVIN|Ensembl=ENSBTAG00000005533|UniProtKB=F1N1S8	Uncharacterized protein	ISS	12110603	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P04393	Ras Pathway	P04557	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	TAS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00018	EGF receptor signaling pathway	P00561	STAT	CHICK|Ensembl=ENSGALG00000003267|UniProtKB=Q6DV79	Signal transducer and activator of transcription 3	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00034	Integrin signalling pathway	P00923	Arf1	BRAFL|Gene=BRAFLDRAFT_263946|UniProtKB=C3Z3B1	Putative uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF304	ADP-RIBOSYLATION FACTOR 1
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00056	VEGF signaling pathway	P01425	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	90172230	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	MOUSE|MGI=MGI=2151136|UniProtKB=Q9JI18	Low-density lipoprotein receptor-related protein 1B	IDA	11907044	PubMed	PTHR44025:SF7	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	IDA	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	14707121	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00017	DNA replication	P00536	DNA Topisomerase	MOUSE|MGI=MGI=98791|UniProtKB=Q64511	DNA topoisomerase 2-beta	ISS			PTHR10169:SF36	DNA TOPOISOMERASE 2-BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00859	NFkappaB	MACMU|Ensembl=ENSMMUG00000002990|UniProtKB=F7GVV0	Uncharacterized protein	ISS	20151924	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	PANTR|Ensembl=ENSPTRG00000005858|UniProtKB=H2Q7J6	Uncharacterized protein	ISS			PTHR24247:SF30	5-HYDROXYTRYPTAMINE RECEPTOR 2A
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	RAT|RGD=620761|UniProtKB=Q9R172	Neurogenic locus notch homolog protein 3	IDA	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00049	Parkinson disease	P01208	Hsp70	LEIMA|EnsemblGenome=LmjF.30.2490|UniProtKB=Q4Q744	Putative heat shock 70-related protein 1,mitochondrial	IDA	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=94924|UniProtKB=P61168	D(2) dopamine receptor	IDA	11248120	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00046	Oxidative stress response	P01135	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00012	Cadherin signaling pathway	P00477	GSK3beta	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	ANOGA|EnsemblGenome=AGAP002974|UniProtKB=Q7QD62	AGAP002974-PA	ISS	85270494	PubMed	PTHR18945:SF592	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-LIKE 1
P00018	EGF receptor signaling pathway	P00558	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	IGI	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	BOVIN|Ensembl=ENSBTAG00000002125|UniProtKB=F1N461	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01181	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	P00546	GAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	2842690	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00038	JAK/STAT signaling pathway	P01027	STAT	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	15825084	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00005	Angiogenesis	P00219	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00029	Huntington disease	P00797	p53	ORNAN|Ensembl=ENSOANG00000013795|UniProtKB=F7DUR2	Uncharacterized protein (Fragment)	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P04393	Ras Pathway	P04563	Ets	MACMU|Ensembl=ENSMMUG00000020706|UniProtKB=F6PU72	Uncharacterized protein	ISS	9157999	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DROME|FlyBase=FBgn0004623|UniProtKB=P29829	Guanine nucleotide-binding protein subunit beta-2	IC	10391901	PubMed	PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00047	PDGF signaling pathway	P01173	STAT	PANTR|Ensembl=ENSPTRG00000005095|UniProtKB=H2Q688	Signal transducer and activator of transcription	ISS			PTHR11801:SF41	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 2
P00012	Cadherin signaling pathway	P00471	Cadherin	BOVIN|Ensembl=ENSBTAG00000002845|UniProtKB=E1BIA5	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF290	CADHERIN-10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00021	FGF signaling pathway	P00640	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00728	RhoGEF	HUMAN|HGNC=681|UniProtKB=Q92888	Rho guanine nucleotide exchange factor 1	IDA	12024019	PubMed	PTHR12673:SF122	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 1
P00047	PDGF signaling pathway	P01154	Ras	DICPU|Gene=DICPUDRAFT_57324|UniProtKB=F0ZVH9	Putative uncharacterized protein rasS	ISS	8290260	PubMed	PTHR24070:SF380	RAS-LIKE PROTEIN RASS
P00034	Integrin signalling pathway	P00919	Arf6	ORNAN|Ensembl=ENSOANG00000012039|UniProtKB=F7DMS9	Uncharacterized protein	ISS			PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	RAT|RGD=620761|UniProtKB=Q9R172	Neurogenic locus notch homolog protein 3	IDA	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00029	Huntington disease	P00807	Actin	DANRE|ZFIN=ZDB-GENE-000329-1|UniProtKB=Q7ZVI7	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P04393	Ras Pathway	P04569	Cdc42	TAKRU|Ensembl=ENSTRUG00000008289|UniProtKB=H2T7U8	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF129	CDC42L PROTEIN
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	CANLF|Ensembl=ENSCAFG00000002528|UniProtKB=F1PS63	Receptor protein serine/threonine kinase	ISS	10683140	PubMed	PTHR23255:SF61	TGF-BETA RECEPTOR TYPE-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	PANTR|Ensembl=ENSPTRG00000007489|UniProtKB=H2QA49	Tyrosine-protein kinase receptor	ISS	11182407	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00019	Endothelin signaling pathway	P00583	cPLA2	BOVIN|Ensembl=ENSBTAG00000013298|UniProtKB=A4IFJ5	Cytosolic phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00034	Integrin signalling pathway	P00922	Collagen	PANTR|Ensembl=ENSPTRG00000014012|UniProtKB=H2QL57	Uncharacterized protein	ISS	10778855	PubMed	PTHR44172:SF3	COLLAGEN ALPHA-1 VI  CHAIN
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	CHICK|Gene=CHRM3|UniProtKB=P49578	Muscarinic acetylcholine receptor M3	TAS	12181435	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DICDI|dictyBase=DDB_G0279413|UniProtKB=P05987	cAMP-dependent protein kinase regulatory subunit	IC	92186968	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00920	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05731	GABA-B receptor II signaling	P05760	AC	MOUSE|MGI=MGI=102891|UniProtKB=P51829	Adenylate cyclase type 7	RCA	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IGI	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00018	EGF receptor signaling pathway	P00539	14-3-3	MONDO|Ensembl=ENSMODG00000013658|UniProtKB=F6TY10	Uncharacterized protein	ISS	1317796	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00052	TGF-beta signaling pathway	P01285	TAK	CHICK|Ensembl=ENSGALG00000015596|UniProtKB=E1C063	Uncharacterized protein	RCA			PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	PANTR|Ensembl=ENSPTRG00000004079|UniProtKB=H2R1Z2	Uncharacterized protein	ISS	9388255	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P00019	Endothelin signaling pathway	P00572	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02920	dCTP deaminase	GLOVI|Gene=BAC91451|UniProtKB=Q7MBC0	dCTP deaminase	RCA			PTHR42680:SF3	DCTP DEAMINASE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04393	Ras Pathway	P04569	Cdc42	YEAST|SGD=S000004219|UniProtKB=P19073	Cell division control protein 42	IDA	11156982	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P05913	Enkephalin release	P05976	Enkephalin	MACMU|Ensembl=ENSMMUG00000009984|UniProtKB=F6R267	Beta-neoendorphin-dynorphin	ISS	131330	OMIM	PTHR11438:SF4	PROENKEPHALIN-B
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	12846562	PubMed	PTHR10202:SF13	PRESENILIN-2
P00056	VEGF signaling pathway	P01407	Erk	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01465	Ggamma	HUMAN|HGNC=19663|UniProtKB=Q9UBI6	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	ISS	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Gene=MYH3|UniProtKB=P02565	Myosin-1B	IEP	89264452	PubMed	PTHR13140:SF657	MYOSIN-4
P00018	EGF receptor signaling pathway	P00559	MEK1-2	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00036	Interleukin signaling pathway	P00976	GSK3	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	SCHPO|PomBase=SPAC4G9.03|UniProtKB=P33075	Adenylate kinase	ISS			PTHR23359:SF117	ADENYLATE KINASE 2, MITOCHONDRIAL
P06959	CCKR signaling map	P07193	CaM	HUMAN|HGNC=1442|UniProtKB=P62158	Calmodulin	RCA		PubMed	PTHR23050:SF311	CALMODULIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	RAT|RGD=2027|UniProtKB=P63269	Actin, gamma-enteric smooth muscle	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P04398	p53 pathway feedback loops 2	P04650	WIP-1	BOVIN|Ensembl=ENSBTAG00000009427|UniProtKB=E1BD03	Uncharacterized protein	ISS			PTHR13832:SF359	PROTEIN PHOSPHATASE 1D
P00018	EGF receptor signaling pathway	P00557	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	IGI	1171954	gi	PTHR10048:SF14	PI-3 KINASE
P00010	B cell activation	P00385	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	PANTR|Ensembl=ENSPTRG00000003943|UniProtKB=H2Q479	Uncharacterized protein	ISS			PTHR10024:SF252	SYNAPTOTAGMIN-12
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	BOVIN|Ensembl=ENSBTAG00000017981|UniProtKB=P46626	Beta-3 adrenergic receptor	IDA	12063255	PubMed	PTHR24248:SF3	BETA-3 ADRENERGIC RECEPTOR
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05916	Opioid prodynorphin pathway	P06002	G-protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	10188796	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00034	Integrin signalling pathway	P00947	Laminin	CAEEL|WormBase=WBGene00001328|UniProtKB=Q21313	Laminin-like protein epi-1	IPI	2538453	PubMed	PTHR10574:SF359	LAMININ SUBUNIT ALPHA-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00036	Interleukin signaling pathway	P00965	ERK	PANTR|Ensembl=ENSPTRG00000020224|UniProtKB=H2Q9G3	Mitogen-activated protein kinase 6	ISS	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00030	Hypoxia response via HIF activation	P00823	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00020	FAS signaling pathway	P00615	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01143	ERK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	HUMAN|HGNC=418|UniProtKB=P09972	Fructose-bisphosphate aldolase C	ISS	2350361	PubMed	PTHR11627:SF3	FRUCTOSE-BISPHOSPHATE ALDOLASE C
P00025	Hedgehog signaling pathway	P00682	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01171	PLCgamma	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P05913	Enkephalin release	P05974	G-Protein (i)	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	ANOGA|EnsemblGenome=AGAP000300|UniProtKB=Q7QF47	AGAP000300-PA	ISS			PTHR11405:SF5	CAD PROTEIN
P00029	Huntington disease	P00788	Calpain	BOVIN|Ensembl=ENSBTAG00000010230|UniProtKB=Q27970	Calpain-1 catalytic subunit	IDA	11675509	PubMed	PTHR10183:SF284	CALPAIN-1 CATALYTIC SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	ARATH|TAIR=AT5G39400|UniProtKB=Q9FLZ5	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN1	ISS			PTHR12305:SF80	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND PROTEIN-TYROSINE-PHOSPHATASE PTEN1
P00015	Circadian clock system	P00505	Cry	CANLF|Ensembl=ENSCAFG00000009379|UniProtKB=F1PNC9	Uncharacterized protein	ISS	10428031	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00021	FGF signaling pathway	P00632	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05913	Enkephalin release	P05974	G-Protein (i)	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	ISS	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CANLF|Ensembl=ENSCAFG00000012181|UniProtKB=F2Z4N7	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	CAEEL|WormBase=WBGene00001612|UniProtKB=P34299	Glutamate receptor 1	ISS	10331083	PubMed	PTHR18966:SF297	GLUTAMATE RECEPTOR 1
P00030	Hypoxia response via HIF activation	P00819	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1203729|UniProtKB=Q61194	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00049	Parkinson disease	P01238	14-3-3	CAEBR|Gene=CBG06174|UniProtKB=A8X0R4	Protein CBR-PAR-5	ISS	21643941	PubMed	PTHR18860:SF21	14-3-3-LIKE PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00839	SHIP	HUMAN|HGNC=6080|UniProtKB=O15357	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	ISS	9824312	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	8787761	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01407	Erk	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00006	Apoptosis signaling pathway	P00269	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05731	GABA-B receptor II signaling	P05754	Ggamma	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MOUSE|MGI=MGI=1309999|UniProtKB=Q922R0	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P05918	p38 MAPK pathway	P06017	MNK2	BOVIN|Ensembl=ENSBTAG00000018049|UniProtKB=E1BCH7	Uncharacterized protein	ISS	11463832	PubMed	PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P00049	Parkinson disease	P01227	20S proteasome	DROME|FlyBase=FBgn0023174|UniProtKB=Q9VUJ1	Proteasome subunit beta type	TAS	12859888	PubMed	PTHR11599:SF44	AT05866P-RELATED
P00052	TGF-beta signaling pathway	P01286	TGFbeta	CHICK|Ensembl=ENSGALG00000003161|UniProtKB=Q98950	CVg1 protein	TAS	10844590	PubMed	PTHR11848:SF151	EMBRYONIC GROWTH/DIFFERENTIATION FACTOR 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IC	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04376	5HT4 type receptor mediated signaling pathway	P04429	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00048	PI3 kinase pathway	P01181	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000008719|UniProtKB=F1MZX0	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00049	Parkinson disease	P01238	14-3-3	MONDO|Ensembl=ENSMODG00000006158|UniProtKB=F7BS95	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00054	Toll receptor signaling pathway	P01345	IKKalpha	CANLF|Ensembl=ENSCAFG00000009588|UniProtKB=E2RNA9	Uncharacterized protein	ISS	14499113	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00907	ERK	BOVIN|Ensembl=ENSBTAG00000009065|UniProtKB=F1MXH6	Uncharacterized protein	ISS			PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00034	Integrin signalling pathway	P00922	Collagen	PANTR|Ensembl=ENSPTRG00000002321|UniProtKB=H2Q1N7	Uncharacterized protein	ISS			PTHR23220:SF5	INTEGRIN ALPHA-8
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Ensembl=ENSPTRG00000011042|UniProtKB=H2QGF5	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_125401|UniProtKB=C3ZTX6	Putative uncharacterized protein	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04393	Ras Pathway	P04546	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	RAT|RGD=2036|UniProtKB=P40146	Adenylate cyclase type 8	IDA	8163524	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00053	T cell activation	P01332	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	MOUSE|MGI=MGI=1309489|UniProtKB=O70589	Peripheral plasma membrane protein CASK	IDA	11679592	PubMed	PTHR23122:SF40	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	ECOLI|EcoGene=EG10327|UniProtKB=P08192	Bifunctional protein FolC	ISS			PTHR11136:SF0	DIHYDROFOLATE SYNTHETASE-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00003	Alzheimer disease-amyloid secretase pathway	P00081	Pro-BACE-1	HUMAN|HGNC=934|UniProtKB=Q9Y5Z0	Beta-secretase 2	IDA			PTHR13683:SF262	BETA-SECRETASE 2
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MACMU|Ensembl=ENSMMUG00000003118|UniProtKB=F7DL70	Uncharacterized protein	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P04397	p53 pathway by glucose deprivation	P04639	AMPK	MACMU|Ensembl=ENSMMUG00000023806|UniProtKB=F7HR74	Uncharacterized protein	ISS			PTHR24343:SF306	5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MOUSE|MGI=MGI=87905|UniProtKB=P68033	Actin, alpha cardiac muscle 1	IC	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00029	Huntington disease	P00810	GAPDH	NEUCR|EnsemblGenome=EFNCRG00000001686|UniProtKB=P54118	Glyceraldehyde-3-phosphate dehydrogenase	IPI			PTHR10836:SF52	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED
P00047	PDGF signaling pathway	P01160	IP3 receptor	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MACMU|Ensembl=ENSMMUG00000022347|UniProtKB=F6ZCH5	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	IDA	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=17293|UniProtKB=Q9BZL6	Serine/threonine-protein kinase D2	ISS	11062248	PubMed	PTHR22968:SF12	SERINE/THREONINE-PROTEIN KINASE D2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ORNAN|Ensembl=ENSOANG00000007405|UniProtKB=F7CIV4	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000022513|UniProtKB=F6YNZ0	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00049	Parkinson disease	P01224	UbcH7	MACMU|Ensembl=ENSMMUG00000018994|UniProtKB=F6XWT0	Uncharacterized protein	ISS	10888878	PubMed	PTHR24068:SF67	UBIQUITIN-CONJUGATING ENZYME E2 L3
P05912	Dopamine receptor mediated signaling pathway	P05959	FLNA	BOVIN|Ensembl=ENSBTAG00000011190|UniProtKB=F1N169	Uncharacterized protein	ISS	9722563	PubMed	PTHR43998:SF6	FILAMIN-A
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT3G59790|UniProtKB=Q9M1Z5	Mitogen-activated protein kinase 10	ISS	11707292	PubMed	PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00034	Integrin signalling pathway	P00944	Actin	CRYNJ|EnsemblGenome=CNA04650|UniProtKB=Q5KP06	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04393	Ras Pathway	P04547	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	XENTR|Xenbase=XB-GENE-963560|UniProtKB=Q0VFC4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	RAT|RGD=1305848|UniProtKB=P85970	Actin-related protein 2/3 complex subunit 2	ISS	12473693	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_114976|UniProtKB=C3YP58	Putative uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IGI	89186920	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PANTR|Ensembl=ENSPTRG00000006890|UniProtKB=H2Q943	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00021	FGF signaling pathway	P00632	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00024	Glycolysis	P00680	Phosphoglyceromutase	SCHMA|EnsemblGenome=Smp_096760|UniProtKB=G4VJD5	Phosphoglycerate mutase	ISS	16904828	gi	PTHR11931:SF0	AT20876P-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CAEBR|Gene=CBG02162|UniProtKB=A8WS33	Protein CBG02162	ISS	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00005	Angiogenesis	P00256	PLC-gamma	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	RAT|RGD=1624206|UniProtKB=P0C2X9	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	ISS			PTHR14516:SF3	DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE, MITOCHONDRIAL
P04393	Ras Pathway	P04552	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00021	FGF signaling pathway	P00628	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01168	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01451	Galpha	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00010	B cell activation	P00398	IP3R	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	IGI	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IPI	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04393	Ras Pathway	P04558	p38	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	4506785	gi	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	XENTR|Xenbase=XB-GENE-479496|UniProtKB=F6S876	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	IC	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04384	Gamma-aminobutyric acid synthesis	P04480	GABA aminotransferase	HUMAN|HGNC=23|UniProtKB=P80404	4-aminobutyrate aminotransferase, mitochondrial	ISS	10989446	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00470	F-actin	STRPU|Gene=CYIIIB|UniProtKB=P18499	Actin, cytoskeletal 3B	IC	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	11832947	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P06959	CCKR signaling map	G06971	TFF2	HUMAN|HGNC=11756|UniProtKB=Q03403	Trefoil factor 2	RCA	17332476	PubMed	PTHR13826:SF17	TREFOIL FACTOR 2
P00034	Integrin signalling pathway	P00944	Actin	RAT|RGD=628837|UniProtKB=P60711	Actin, cytoplasmic 1	IPI	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DICDI|dictyBase=DDB_G0283907|UniProtKB=P34099	cAMP-dependent protein kinase catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	BOVIN|Ensembl=ENSBTAG00000020983|UniProtKB=Q2TBH2	Related RAS viral (R-ras) oncogene homolog	ISS	7997267	PubMed	PTHR24070:SF245	RAS-RELATED PROTEIN R-RAS
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	CHICK|Ensembl=ENSGALG00000013224|UniProtKB=F1NMA4	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000017332|UniProtKB=Q5DRD1	Protocadherin beta-3	ISS	8120095	PubMed	PTHR24028:SF118	PROTOCADHERIN BETA-3
P00047	PDGF signaling pathway	P01168	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00236	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	RAT|RGD=1304556|UniProtKB=P63259	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04669	ATM	EMENI|EnsemblGenome=CADANIAG00000506|UniProtKB=C8VB89	UVSB [Source:UniProtKB/TrEMBLAcc:Q9UV56]	ISS			PTHR11139:SF69	SERINE/THREONINE-PROTEIN KINASE ATR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	RAT|RGD=621353|UniProtKB=P08082	Clathrin light chain B	ISS	11889126	PubMed	PTHR10639:SF2	CLATHRIN LIGHT CHAIN B
P00046	Oxidative stress response	P01129	JNK1/2	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95817|UniProtKB=Q8BMF5	Glutamate receptor ionotropic, kainate 4	ISS	1648176	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	ISS	11889126	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	DROME|FlyBase=FBgn0263111|UniProtKB=P91645	Voltage-dependent calcium channel type A subunit alpha-1	ISS	14624853	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P00048	PI3 kinase pathway	P01188	Gbetagamma	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00050	Plasminogen activating cascade	P01253	Fibrin	BOVIN|Gene=FGB|UniProtKB=P02676	Fibrinogen beta chain	ISS			PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00013	Cell cycle	P00480	Proteasome	MOUSE|MGI=MGI=1913284|UniProtKB=O35593	26S proteasome non-ATPase regulatory subunit 14	ISS	9727008	PubMed	PTHR10410:SF5	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 14
P00019	Endothelin signaling pathway	P00572	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00006	Apoptosis signaling pathway	P00310	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00045	Notch signaling pathway	P01105	TACE	CHICK|Ensembl=ENSGALG00000004212|UniProtKB=F6VMG5	Uncharacterized protein	ISS			PTHR11905:SF4	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 10
P00052	TGF-beta signaling pathway	P01284	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00020	FAS signaling pathway	P00616	Nuclear Lamin	RAT|RGD=620522|UniProtKB=P70615	Lamin-B1	TAS	11165516	PubMed	PTHR23239:SF157	LAMIN-B1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	IC	91056091	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00029	Huntington disease	P00778	NMDA receptor	BOVIN|Ensembl=ENSBTAG00000018445|UniProtKB=E1BK87	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P04393	Ras Pathway	P04570	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01332	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04393	Ras Pathway	P04572	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00551	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00550	Grb2	CAEBR|Gene=CBG16856|UniProtKB=A8XPY6	Protein CBR-SEM-5	ISS	8307166	PubMed	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P02747	Histidine biosynthesis	P02987	ATP phosphoribosyl transferase	STRCO|EnsemblGenome=CAD55174|UniProtKB=Q8CK28	ATP phosphoribosyltransferase	ISS			PTHR21403:SF4	ATP PHOSPHORIBOSYLTRANSFERASE
P00049	Parkinson disease	P01236	Casein kinase II	ARATH|TAIR=AT5G47080|UniProtKB=P40228	Casein kinase II subunit beta	IDA	10806215	PubMed	PTHR11740:SF15	CASEIN KINASE II SUBUNIT BETA-RELATED
P00019	Endothelin signaling pathway	P00577	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IGI	7937853	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	CAEEL|WormBase=WBGene00001679|UniProtKB=P17343	Guanine nucleotide-binding protein subunit beta-1	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	IDA	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	HUMAN|HGNC=3020|UniProtKB=P21728	D(1A) dopamine receptor	ISS	15328036	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00029	Huntington disease	P00774	Dynein complex	CHICK|Ensembl=ENSGALG00000011491|UniProtKB=Q90828	Cytoplasmic dynein 1 light intermediate chain 1	IPI	9454836	PubMed	PTHR12688:SF2	CYTOPLASMIC DYNEIN 1 LIGHT INTERMEDIATE CHAIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01331	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00059	p53 pathway	P01480	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	IGI	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00046	Oxidative stress response	P01131	MKP5	MOUSE|MGI=MGI=1890614|UniProtKB=Q9D0T2	Dual specificity protein phosphatase 12	ISS			PTHR10159:SF293	DUAL SPECIFICITY PROTEIN PHOSPHATASE 12
P04397	p53 pathway by glucose deprivation	P04639	AMPK	HUMAN|HGNC=9376|UniProtKB=Q13131	5'-AMP-activated protein kinase catalytic subunit alpha-1	ISS			PTHR24343:SF306	5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	TAS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00045	Notch signaling pathway	P01107	Fringe	RAT|RGD=620587|UniProtKB=Q924T4	Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe	ISS	12670869	PubMed	PTHR10811:SF7	BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE LUNATIC FRINGE
P00011	Blood coagulation	P00444	FIX	PANTR|Gene=F9|UniProtKB=Q95ND7	Coagulation factor IX	ISS	14270123	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P02763	Peptidoglycan biosynthesis	P03090	N-Acetylglucosaminyl transferase	ARATH|TAIR=AT1G73740|UniProtKB=Q9C9T8	Glycosyltransferase	ISS			PTHR21015:SF22	GLYCOSYLTRANSFERASE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04454	CRF	MOUSE|MGI=MGI=88496|UniProtKB=Q8CIT0	Corticoliberin	ISS	122560	OMIM	PTHR15035:SF9	CORTICOLIBERIN
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IGI	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00029	Huntington disease	P00799	JNK-2	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	PANTR|Ensembl=ENSPTRG00000013628|UniProtKB=H2R4F5	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00249	PAK	BOVIN|Ensembl=ENSBTAG00000010191|UniProtKB=Q08E52	Serine/threonine-protein kinase PAK 1	ISS	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	88248000	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	G01532	PolyQ HTT	MOUSE|MGI=MGI=96067|UniProtKB=P42859	Huntingtin	TAS	7620118	PubMed	PTHR10170:SF10	HUNTINGTIN
P00057	Wnt signaling pathway	P01438	PP2A	BRAFL|Gene=BRAFLDRAFT_123893|UniProtKB=C3XQF4	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00050	Plasminogen activating cascade	P01247	TAFI	MACMU|Ensembl=ENSMMUG00000017029|UniProtKB=F7HQV5	Uncharacterized protein	ISS			PTHR11705:SF17	CARBOXYPEPTIDASE B2
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00023	General transcription regulation	P00658	TBP-associated factors	CANLF|Ensembl=ENSCAFG00000001622|UniProtKB=E2RN76	Uncharacterized protein	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	NEUCR|EnsemblGenome=EFNCRG00000001796|UniProtKB=Q8WZY4	26S proteasome regulatory subunit rpn-8	ISS	18376158	gi	PTHR10540:SF7	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	XENTR|Xenbase=XB-GENE-494200|UniProtKB=F7CS79	Uncharacterized protein	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00206	Wnt	XENTR|Xenbase=XB-GENE-485280|UniProtKB=F6X3B2	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00057	Wnt signaling pathway	P01438	PP2A	MONDO|Ensembl=ENSMODG00000002945|UniProtKB=F6PKB8	Uncharacterized protein	ISS	12110603	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Gene=CHRM2|UniProtKB=Q9N2A7	Muscarinic acetylcholine receptor M2 (Fragment)	ISS	8100450	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04380	Cortocotropin releasing factor receptor signaling pathway	G04671	proopiomelanocortin	MONDO|Ensembl=ENSMODG00000015853|UniProtKB=Q95J84	Proopiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00017	DNA replication	P00527	Histones	STRPU|EnsemblGenome=SPU_018560|UniProtKB=W4YRX5	Histone H3	ISS	12413958	PubMed	PTHR11426:SF20	HISTONE H3-LIKE CENTROMERIC PROTEIN A
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CAEEL|WormBase=WBGene00001187|UniProtKB=Q8MQA1	Uncharacterized protein	IC	11956331	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00848	Grb	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12186904	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00009	Axon guidance mediated by netrin	P00364	cdc42	XENTR|Xenbase=XB-GENE-967585|UniProtKB=Q28BZ0	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00079	alpha7 nicotinic acetylcholine receptor	MONDO|Ensembl=ENSMODG00000008920|UniProtKB=F7GL76	Uncharacterized protein	ISS			PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P00021	FGF signaling pathway	P00642	MEK1-2	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00010	B cell activation	P00398	IP3R	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	IGI	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00007	Axon guidance mediated by semaphorins	P00337	Sema3A	CANLF|Ensembl=ENSCAFG00000006212|UniProtKB=E2QX94	Uncharacterized protein	ISS			PTHR11036:SF23	SEMAPHORIN-3A
P00021	FGF signaling pathway	P00627	ERK1-2	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=11332|UniProtKB=P32745	Somatostatin receptor type 3	IDA	12441358	PubMed	PTHR24229:SF42	SOMATOSTATIN RECEPTOR TYPE 3
P00029	Huntington disease	P00797	p53	DANRE|ZFIN=ZDB-GENE-030131-8557|UniProtKB=Q90YM8	Cytoplasmic FMR1-interacting protein 1 homolog	ISS			PTHR12195:SF2	CYTOPLASMIC FMR1-INTERACTING PROTEIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00054	Toll receptor signaling pathway	P01341	Elk1	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	9644975	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00056	VEGF signaling pathway	P01408	Akt/PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00045	Notch signaling pathway	P01119	NIct	MOUSE|MGI=MGI=99460|UniProtKB=Q61982	Neurogenic locus notch homolog protein 3	IC	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00005	Angiogenesis	P00206	Wnt	RAT|RGD=69250|UniProtKB=Q9QXQ7	Protein Wnt-5a	ISS	8717036	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DANRE|ZFIN=ZDB-GENE-041210-195|UniProtKB=F1R506	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00049	Parkinson disease	P01238	14-3-3	EMENI|EnsemblGenome=CADANIAG00005943|UniProtKB=Q5B4M9	1433_TRIHA 14-3-3 PROTEIN HOMOLOG (TH1433)	IDA	12023078	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00019	Endothelin signaling pathway	P00590	IP3 R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04393	Ras Pathway	P04557	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04393	Ras Pathway	P04547	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00034	Integrin signalling pathway	P00920	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02738	De novo purine biosynthesis	P02889	dGDP kinase	TRYB2|Gene=Tb11.01.7800|UniProtKB=Q381H3	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01094	gamma	MOUSE|MGI=MGI=87895|UniProtKB=P04760	Acetylcholine receptor subunit gamma	ISS	95224005	PubMed	PTHR18945:SF60	ACETYLCHOLINE RECEPTOR SUBUNIT GAMMA
P02751	Lysine biosynthesis	P03006	Dihydrodipicolinate  reductase	STRCO|EnsemblGenome=CAA20290|UniProtKB=O86836	4-hydroxy-tetrahydrodipicolinate reductase	ISS			PTHR20836:SF0	DIHYDRODIPICOLINATE REDUCTASE-LIKE PROTEIN CRR1, CHLOROPLASTIC
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-486685|UniProtKB=F6VT32	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00060	Ubiquitin proteasome pathway	P01490	E3	PANTR|Ensembl=ENSPTRG00000008288|UniProtKB=H2R2Z9	E3 ubiquitin-protein ligase	ISS			PTHR11254:SF396	NEDD4-LIKE E3 UBIQUITIN-PROTEIN LIGASE WWP2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	CANLF|Ensembl=ENSCAFG00000016335|UniProtKB=J9NXY2	Uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF322	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01196	PDK1	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	IDA	9094314	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00020	FAS signaling pathway	P00598	Pro-Caspase10	HUMAN|HGNC=1500|UniProtKB=Q92851	Caspase-10	IGI	8755496	PubMed	PTHR10454:SF26	CASPASE-10
P00018	EGF receptor signaling pathway	P00564	Rac	CAEEL|WormBase=WBGene00004287|UniProtKB=Q94124	Ras-related protein rac-2	IGI	22392988	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	DROME|FlyBase=FBgn0011286|UniProtKB=Q24498	Ryanodine receptor	ISS	93202018	PubMed	PTHR13715:SF79	RYANODINE RECEPTOR
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00034	Integrin signalling pathway	P00911	B-Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00021	FGF signaling pathway	P00626	Spry	DROME|FlyBase=FBgn0014388|UniProtKB=O44783	Protein sprouty	ISS	98117253	PubMed	PTHR12365:SF7	PROTEIN SPROUTY
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	MONDO|Ensembl=ENSMODG00000015399|UniProtKB=F6T507	Uncharacterized protein	ISS	94365697	PubMed	PTHR11958:SF69	EXCITATORY AMINO ACID TRANSPORTER 3
P00029	Huntington disease	P00811	Arp2/3 complex	BOVIN|Ensembl=ENSBTAG00000004242|UniProtKB=Q1JP79	Actin-related protein 2/3 complex subunit 1A	ISS	12963527	gi	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	MACMU|Ensembl=ENSMMUG00000001789|UniProtKB=F7GIU0	5-hydroxytryptamine receptor 1A	ISS	2156831	PubMed	PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00018	EGF receptor signaling pathway	P00563	Gab	RAT|RGD=621367|UniProtKB=Q9EQH1	GRB2-associated-binding protein 2	IGI	15356145	PubMed	PTHR12156:SF4	GRB2-ASSOCIATED-BINDING PROTEIN 2
P00021	FGF signaling pathway	P00625	MKK3,6	RAT|RGD=1306620|UniProtKB=B1H230	Map2k3 protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	MACMU|Ensembl=ENSMMUG00000005384|UniProtKB=F7GUL4	Suppressor of cytokine signaling 5	ISS	22247722	PubMed	PTHR44282:SF3	SUPPRESSOR OF CYTOKINE SIGNALING 5
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04398	p53 pathway feedback loops 2	P04657	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IGI	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04395	Vasopressin synthesis	P04599	Amidating Enzyme	HUMAN|HGNC=8596|UniProtKB=P19021	Peptidyl-glycine alpha-amidating monooxygenase	IC	3153462	PubMed	PTHR10680:SF14	PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00210	eNOS	MACMU|Ensembl=ENSMMUG00000020437|UniProtKB=F6WEB2	Nitric oxide synthase	ISS	93055452	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	XENTR|Xenbase=XB-GENE-866811|UniProtKB=F7EI91	Uncharacterized protein (Fragment)	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CAEEL|WormBase=WBGene00006454|UniProtKB=G5EEN8	AEX-4	ISS			PTHR19305:SF10	AEX-4
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	HUMAN|HGNC=1402|UniProtKB=Q08289	Voltage-dependent L-type calcium channel subunit beta-2	IC	20088160	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00057	Wnt signaling pathway	P01432	Beta-Catenin	ORNAN|Ensembl=ENSOANG00000006811|UniProtKB=F6WBD5	Uncharacterized protein	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000014334|UniProtKB=F7CYY6	Uncharacterized protein	ISS	11248120	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=628675|UniProtKB=Q9Z2A6	Mitogen-activated protein kinase 15	IDA	10851062	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00010	B cell activation	P00401	jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	ISS	14744463	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IGI	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	PANTR|Ensembl=ENSPTRG00000023608|UniProtKB=H2QZZ2	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00047	PDGF signaling pathway	P01154	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	HUMAN|HGNC=4589|UniProtKB=Q7Z429	Protein lifeguard 1	ISS			PTHR23291:SF16	PROTEIN LIFEGUARD 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PRIPA|Gene=PPA23459|UniProtKB=H3FMF2	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	MONDO|Ensembl=ENSMODG00000015793|UniProtKB=F7FS26	Uncharacterized protein	ISS			PTHR11405:SF38	CARBAMOYL-PHOSPHATE SYNTHASE  AMMONIA , MITOCHONDRIAL
P00020	FAS signaling pathway	P00594	Caspase8	MOUSE|MGI=MGI=1336166|UniProtKB=O35732	CASP8 and FADD-like apoptosis regulator	IGI	8681376	PubMed	PTHR10454:SF8	CASP8 AND FADD-LIKE APOPTOSIS REGULATOR
P00010	B cell activation	P00385	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12912997	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00049	Parkinson disease	P01227	20S proteasome	PANTR|Ensembl=ENSPTRG00000019120|UniProtKB=H2R5C6	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF16	PROTEASOME SUBUNIT ALPHA TYPE-2
P00005	Angiogenesis	P00243	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00053	T cell activation	P01334	WASP	MOUSE|MGI=MGI=105059|UniProtKB=P70315	Wiskott-Aldrich syndrome protein homolog	IGI	10544204	PubMed	PTHR23202:SF35	WISKOTT-ALDRICH SYNDROME PROTEIN
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000001014|UniProtKB=A5PKJ4	Mitogen-activated protein kinase 7	ISS	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00057	Wnt signaling pathway	P01453	Ebi	ORNAN|Ensembl=ENSOANG00000009691|UniProtKB=F6S036	Uncharacterized protein	ISS	11389839	PubMed	PTHR22846:SF2	F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN TBL1X
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00059	p53 pathway	P01486	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	TAS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00583	cPLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00049	Parkinson disease	P01238	14-3-3	ENTHI|EnsemblGenome=EHI_006810|UniProtKB=C4M0F4	14-3-3 protein 3	IDA	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	TAS	97320448	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	METJA|EnsemblGenome=MJ_1265|UniProtKB=Q58661	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00005	Angiogenesis	P00253	Axin	CHICK|Ensembl=ENSGALG00000004021|UniProtKB=F1P136	Uncharacterized protein	ISS			PTHR10845:SF103	AXIN-2
P00046	Oxidative stress response	P01131	MKP5	RAT|RGD=1594806|UniProtKB=D3ZH31	Protein Styx	ISS			PTHR10159:SF385	SERINE/THREONINE/TYROSINE-INTERACTING PROTEIN
P00023	General transcription regulation	P00669	TFIIEalpha	CAEEL|WormBase=WBGene00013998|UniProtKB=G5EG49	TFIIE-alpha protein	ISS			PTHR13097:SF7	NOVEL PROTEIN SIMILAR TO VERTEBRATE GENERAL TRANSCRIPTION FACTOR IIE POLYPEPTIDE 1 ALPHA 56KDA  GTF2E1
P06664	Gonadotropin-releasing hormone receptor pathway	G06881	Rap1b	MOUSE|MGI=MGI=894315|UniProtKB=Q99JI6	Ras-related protein Rap-1b	RCA	1904317	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00513	Op18/stathmin	HUMAN|HGNC=6510|UniProtKB=P16949	Stathmin	IEA	http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=3925	Website	PTHR10104:SF5	STATHMIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00012	Cadherin signaling pathway	P00470	F-actin	TRIVA|Gene=TVAG_512800|UniProtKB=A2HNG1	Actin (Fragment)	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	CHICK|Ensembl=ENSGALG00000005518|UniProtKB=F1NTL1	Protein-serine/threonine kinase	ISS	10852916	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00182	p38MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	HUMAN|HGNC=4582|UniProtKB=Q16099	Glutamate receptor ionotropic, kainate 4	ISS	12871085	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9095200	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=98954|UniProtKB=P21552	Protein Wnt-2	TAS	11266476	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00018	EGF receptor signaling pathway	P00565	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IGI	10644715	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	PANTR|Ensembl=ENSPTRG00000002064|UniProtKB=H2R817	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	RCA	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00049	Parkinson disease	P01211	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00049	Parkinson disease	P01208	Hsp70	HUMAN|HGNC=5239|UniProtKB=P17066	Heat shock 70 kDa protein 6	IDA	12150907	PubMed	PTHR19375:SF168	HEAT SHOCK 70 KDA PROTEIN 6-RELATED
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=98957|UniProtKB=P22724	Protein Wnt-4	IDA	8717036	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00752	cGMP-gated ion channel	BOVIN|Gene=CNGB1|UniProtKB=Q28181	Cyclic nucleotide-gated cation channel beta-1	IDA	12432397	PubMed	PTHR10217:SF386	CYCLIC NUCLEOTIDE-GATED CATION CHANNEL BETA-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	CANLF|Gene=PPP1CC|UniProtKB=Q8MJ46	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	ISS	8392016	PubMed	PTHR11668:SF204	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-GAMMA CATALYTIC SUBUNIT
P00047	PDGF signaling pathway	P01154	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000002016|UniProtKB=F1P3G1	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00023	General transcription regulation	P00658	TBP-associated factors	PANTR|Ensembl=ENSPTRG00000018075|UniProtKB=H2QSV3	TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa	ISS			PTHR13218:SF16	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MONDO|Ensembl=ENSMODG00000005623|UniProtKB=F7CFG8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00029	Huntington disease	P00807	Actin	DICPU|Gene=DICPUDRAFT_48914|UniProtKB=F0ZK40	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF154	ACTIN-17-RELATED
P00056	VEGF signaling pathway	P01425	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000010521|UniProtKB=F7DQK7	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	ARATH|TAIR=AT5G41480|UniProtKB=F4JYE9	Dihydrofolate synthetase	ISS			PTHR11136:SF0	DIHYDROFOLATE SYNTHETASE-RELATED
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12701063	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DANRE|ZFIN=ZDB-GENE-050417-59|UniProtKB=Q15KE4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00057	Wnt signaling pathway	P01438	PP2A	MONDO|Ensembl=ENSMODG00000019001|UniProtKB=F7CP86	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00009	Axon guidance mediated by netrin	P00363	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P06959	CCKR signaling map	P07086	PLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	RCA	7573455	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00020	FAS signaling pathway	P00616	Nuclear Lamin	DANRE|ZFIN=ZDB-GENE-020424-4|UniProtKB=Q6P0Z0	Lamin L3	TAS	11165516	PubMed	PTHR23239:SF119	LAMIN L3
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00029	Huntington disease	P00790	beta-Tubulin	ORYSJ|EnsemblGenome=OS03G0780600|UniProtKB=P37832	Tubulin beta-7 chain	TAS	9454836	PubMed	PTHR11588:SF146	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04568	MKK3/6	MACMU|Ensembl=ENSMMUG00000010904|UniProtKB=F7GLY5	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	PANTR|Ensembl=ENSPTRG00000018361|UniProtKB=P60020	5-hydroxytryptamine receptor 1B	ISS	11701344	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P00029	Huntington disease	P00807	Actin	ARATH|TAIR=AT2G42100|UniProtKB=Q8RYC2	Putative actin-5	IDA	14684598	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MOUSE|MGI=MGI=1346873|UniProtKB=Q61083	Mitogen-activated protein kinase kinase kinase 2	ISS	8649450	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	BOVIN|Ensembl=ENSBTAG00000047202|UniProtKB=G3N3K3	Uncharacterized protein	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	PANTR|Ensembl=ENSPTRG00000017238|UniProtKB=H2QRH7	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00059	p53 pathway	P04623	CBP	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	MACMU|Ensembl=ENSMMUG00000018272|UniProtKB=F7HEB8	Uncharacterized protein	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	PANTR|Ensembl=ENSPTRG00000023608|UniProtKB=H2QZZ2	Uncharacterized protein	ISS	11554549	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00034	Integrin signalling pathway	P00938	Cdc42	ANOGA|EnsemblGenome=AGAP002440|UniProtKB=Q17031	Cdc42 homolog	ISS	4757952	gi	PTHR24072:SF192	CDC42 HOMOLOG
P02729	Ascorbate degradation	P02852	L-xylulose-5-phosphate-3-epimerase	DEIRA|EnsemblGenome=DR_1401|UniProtKB=Q9RUI5	Ribulose-phosphate 3-epimerase	ISS			PTHR11749:SF3	RIBULOSE-PHOSPHATE 3-EPIMERASE
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	RAT|RGD=1306737|UniProtKB=Q66HF8	Aldehyde dehydrogenase X, mitochondrial	IC			PTHR11699:SF207	ALDEHYDE DEHYDROGENASE X, MITOCHONDRIAL
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_114958|UniProtKB=C3XZ13	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF359	SUBFAMILY NOT NAMED
P00023	General transcription regulation	P00670	TBP	MACMU|Ensembl=ENSMMUG00000009889|UniProtKB=F6YKC3	Uncharacterized protein	ISS			PTHR15938:SF0	HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00052	TGF-beta signaling pathway	P01284	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	BOVIN|Ensembl=ENSBTAG00000037726|UniProtKB=P10895	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	10934033	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	BOVIN|Ensembl=ENSBTAG00000005359|UniProtKB=P21214	Transforming growth factor beta-2	ISS	9759503	PubMed	PTHR11848:SF141	TRANSFORMING GROWTH FACTOR BETA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	DROME|FlyBase=FBgn0262029|UniProtKB=M9MRE4	Dachs, isoform E	IC			PTHR13140:SF498	DACHS, ISOFORM E
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	TAS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	DICPU|Gene=DICPUDRAFT_57324|UniProtKB=F0ZVH9	Putative uncharacterized protein rasS	ISS	8290260	PubMed	PTHR24070:SF380	RAS-LIKE PROTEIN RASS
P00019	Endothelin signaling pathway	P00566	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MACMU|Ensembl=ENSMMUG00000016428|UniProtKB=F7GU00	Metabotropic glutamate receptor 1 isoform alpha	ISS	7476890	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00050	Plasminogen activating cascade	P01250	MMP-13	MOUSE|MGI=MGI=1340026|UniProtKB=P33435	Collagenase 3	ISS	91093077	PubMed	PTHR10201:SF165	COLLAGENASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MONDO|Ensembl=ENSMODG00000018065|UniProtKB=F7G485	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000020588|UniProtKB=F7C0E0	Uncharacterized protein	ISS	11554554	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	BOVIN|Gene=ADRBK1|UniProtKB=P21146	Beta-adrenergic receptor kinase 1	IDA	10852916	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01425	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00539	14-3-3	CHICK|Ensembl=ENSGALG00000006743|UniProtKB=Q5ZKJ2	Uncharacterized protein	ISS	14593000	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00057	Wnt signaling pathway	P01465	Ggamma	HUMAN|HGNC=14131|UniProtKB=Q9P2W3	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13	IDA	10391901	PubMed	PTHR15936:SF2	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-13
P00005	Angiogenesis	P00256	PLC-gamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00647	SHP2	MONDO|Ensembl=ENSMODG00000018156|UniProtKB=F7CWQ1	Tyrosine-protein phosphatase non-receptor type	ISS	14525967	PubMed	PTHR19134:SF65	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 6
P00049	Parkinson disease	P01238	14-3-3	CAEBR|Gene=CBG06174|UniProtKB=A8X0R4	Protein CBR-PAR-5	ISS	22318813	PubMed	PTHR18860:SF21	14-3-3-LIKE PROTEIN 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04451	CRHR1	BOVIN|Ensembl=ENSBTAG00000014381|UniProtKB=F1MFI6	Uncharacterized protein	ISS	11145609	PubMed	PTHR12011:SF274	CORTICOTROPIN-RELEASING FACTOR RECEPTOR 2
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	ARATH|TAIR=AT2G45100|UniProtKB=F4IW19	Cyclin/Brf1-like TBP-binding protein	ISS			PTHR11618:SF4	TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	PANTR|Gene=HTR1F|UniProtKB=Q9N2D9	5-hydroxytryptamine receptor 1F (Fragment)	IDA			PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00049	Parkinson disease	P01238	14-3-3	ASHGO|EnsemblGenome=AGOS_AGR107C|UniProtKB=Q74ZU1	AGR107Cp	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	IC	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IC	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00641	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00023	General transcription regulation	P00666	TFIIE	ANOGA|EnsemblGenome=AGAP005382|UniProtKB=Q7Q7C7	Transcription initiation factor IIE subunit beta	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P00048	PI3 kinase pathway	P01192	p110	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00251	cPLA2	CANLF|Ensembl=ENSCAFG00000013778|UniProtKB=F6UQ33	Phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	ORNAN|Ensembl=ENSOANG00000000818|UniProtKB=F6PLI7	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00642	MEK1-2	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IGI	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=5286|UniProtKB=P08908	5-hydroxytryptamine receptor 1A	IDA	12441358	PubMed	PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P05915	Opioid proenkephalin pathway	P05994	G-protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	ISS	15860573	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	9009705	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01465	Ggamma	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00029	Huntington disease	P00807	Actin	DANRE|ZFIN=ZDB-GENE-030131-172|UniProtKB=Q6IQR3	Actin, alpha, cardiac muscle 1a	IDA	10974003	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	SULSO|EnsemblGenome=SSO0929|UniProtKB=Q97ZH9	Ribonucleotide reductase (Nrd)	ISS			PTHR43371:SF1	SUBFAMILY NOT NAMED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00035	Interferon-gamma signaling pathway	P00958	PIAS	HUMAN|HGNC=16861|UniProtKB=Q9Y6X2	E3 SUMO-protein ligase PIAS3	TAS	8682149	PubMed	PTHR10782:SF10	E3 SUMO-PROTEIN LIGASE PIAS3
P00018	EGF receptor signaling pathway	P00546	GAP	CANLF|Ensembl=ENSCAFG00000018592|UniProtKB=F1PIZ0	Uncharacterized protein	ISS	8982875	PubMed	PTHR10194:SF60	NEUROFIBROMIN
P00049	Parkinson disease	P01211	ERK	MOUSE|MGI=MGI=1346347|UniProtKB=Q9WVS8	Mitogen-activated protein kinase 7	IDA	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P04398	p53 pathway feedback loops 2	P04651	Ras	XENTR|Xenbase=XB-GENE-494548|UniProtKB=F7EC26	Uncharacterized protein	ISS	20362513	PubMed	PTHR24070:SF186	GTPASE KRAS
P00010	B cell activation	P00381	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	IGI	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00053	T cell activation	P01332	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00807	Actin	PHYIT|EnsemblGenome=PITG_15117|UniProtKB=D0NRP9	Actin-like protein	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	P01438	PP2A	MOUSE|MGI=MGI=2388480|UniProtKB=Q6PD28	Protein Ppp2r5b	ISS	96161994	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00778	NMDA receptor	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	IDA	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04398	p53 pathway feedback loops 2	P04664	cyclin E	CHICK|Gene=CCNE1|UniProtKB=P49707	G1/S-specific cyclin-E1	NAS	1705768	gi	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01192	p110	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00583	cPLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000022548|UniProtKB=F6Y9J9	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00034	Integrin signalling pathway	P00924	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IPI	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01131	MKP5	BOVIN|Ensembl=ENSBTAG00000017459|UniProtKB=Q5BIP9	Dual specificity protein phosphatase 18	ISS			PTHR10159:SF313	DUAL SPECIFICITY PROTEIN PHOSPHATASE 18
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	MACMU|Ensembl=ENSMMUG00000013047|UniProtKB=F7H808	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DROME|FlyBase=FBgn0003093|UniProtKB=P13678	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	RAT|RGD=2641|UniProtKB=Q62844	Tyrosine-protein kinase Fyn	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00038	JAK/STAT signaling pathway	P01027	STAT	MACMU|Ensembl=ENSMMUG00000005617|UniProtKB=F6WDY6	Signal transducer and activator of transcription	ISS	12496413	PubMed	PTHR11801:SF19	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00840	GPRK	HUMAN|HGNC=4545|UniProtKB=P43250	G protein-coupled receptor kinase 6	IDA	8288567	PubMed	PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	DANRE|ZFIN=ZDB-GENE-051202-1|UniProtKB=E7F101	Uncharacterized protein	ISS	11554554	PubMed	PTHR44391:SF2	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00203	Erk	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01428	Frizzled	CHICK|Gene=FZD10|UniProtKB=Q9PWH2	Frizzled-10	IDA	8717036	PubMed	PTHR11309:SF86	FRIZZLED-10
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MACMU|Ensembl=ENSMMUG00000016089|UniProtKB=F7GMZ4	Neuronal acetylcholine receptor subunit beta-2	ISS	22213672	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000000985|UniProtKB=F6VRS9	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	RAT|RGD=2738|UniProtKB=Q00960	Glutamate receptor ionotropic, NMDA 2B	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01142	p90RSK	RAT|RGD=620676|UniProtKB=F1M7N7	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MACMU|Ensembl=ENSMMUG00000019342|UniProtKB=F6PVY4	Uncharacterized protein	ISS	12963527	gi	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	DANRE|ZFIN=ZDB-GENE-000330-9|UniProtKB=Q90ZE4	Presenilin-2	IDA	12424519	PubMed	PTHR10202:SF13	PRESENILIN-2
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	MOUSE|MGI=MGI=95818|UniProtKB=Q61626	Glutamate receptor ionotropic, kainate 5	ISS	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P02746	Heme biosynthesis	P02976	Protoporphyrinogen oxidase	BACSU|EnsemblGenome=BSU10140|UniProtKB=P32397	Protoporphyrinogen oxidase	ISS			PTHR42923:SF3	PROTOPORPHYRINOGEN OXIDASE
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	XENTR|Xenbase=XB-GENE-975313|UniProtKB=F7CSQ4	Uncharacterized protein	ISS	94365697	PubMed	PTHR11958:SF24	EXCITATORY AMINO ACID TRANSPORTER 1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00049	Parkinson disease	P01211	ERK	MOUSE|MGI=MGI=1346347|UniProtKB=Q9WVS8	Mitogen-activated protein kinase 7	IDA	12912994	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P04398	p53 pathway feedback loops 2	P04665	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	15572354	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	DANRE|ZFIN=ZDB-GENE-030131-7595|UniProtKB=Q6PBR4	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	HUMAN|HGNC=130|UniProtKB=P62736	Actin, aortic smooth muscle	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	MACMU|Ensembl=ENSMMUG00000012657|UniProtKB=F7E7J1	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P05912	Dopamine receptor mediated signaling pathway	P05955	DBH	MOUSE|MGI=MGI=94864|UniProtKB=Q64237	Dopamine beta-hydroxylase	ISS	90219125	PubMed	PTHR10157:SF29	DOPAMINE BETA-HYDROXYLASE
P00005	Angiogenesis	P00243	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	PANTR|Ensembl=ENSPTRG00000020054|UniProtKB=H2QVU7	Metalloendopeptidase	ISS	9759503	PubMed	PTHR43978:SF3	BONE MORPHOGENETIC PROTEIN 1
P00005	Angiogenesis	P00256	PLC-gamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=262|UniProtKB=P30542	Adenosine receptor A1	ISS	11781138	PubMed	PTHR24246:SF1	ADENOSINE RECEPTOR A1
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05918	p38 MAPK pathway	P06041	Cdc42	MACMU|Ensembl=ENSMMUG00000022009|UniProtKB=F6RBZ7	Cell division control protein 42 homolog isoform 2	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ORYSJ|EnsemblGenome=OS04G0485000|UniProtKB=Q8W425	26S proteasome non-ATPase regulatory subunit 6	ISS			PTHR14145:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	HUMAN|HGNC=17300|UniProtKB=Q7Z7C8	Transcription initiation factor TFIID subunit 8	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00797	p53	MOUSE|MGI=MGI=98834|UniProtKB=P02340	Cellular tumor antigen p53	TAS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00053	T cell activation	P01307	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IPI	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00010	B cell activation	P00376	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P04393	Ras Pathway	P04570	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00474	Wnt	CANLF|Ensembl=ENSCAFG00000008760|UniProtKB=E2RTG8	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P02761	Pantothenate biosynthesis	P03068	Pantoate-beta-alanine ligase	RHOBA|EnsemblGenome=RB3735|UniProtKB=Q7UTQ8	Pantothenate synthetase	ISS			PTHR21299:SF1	PANTOATE--BETA-ALANINE LIGASE
P00049	Parkinson disease	P01211	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00637	MKK4,7	CHICK|Ensembl=ENSGALG00000001001|UniProtKB=F1P3T1	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00048	PI3 kinase pathway	P01182	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00018	EGF receptor signaling pathway	P00551	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	G04694	p110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CAEEL|WormBase=WBGene00004036|UniProtKB=G5EFI8	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IDA	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	STRPU|EnsemblGenome=SPU_009263|UniProtKB=W4Y0P1	Uncharacterized protein	ISS			PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00054	Toll receptor signaling pathway	P01375	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000001583|UniProtKB=F7BBM1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00010	B cell activation	P00376	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	ISS	12805548	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MONDO|Ensembl=ENSMODG00000013970|UniProtKB=F6R6X5	Uncharacterized protein	ISS	11431030	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	15528206	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	176892	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00059	p53 pathway	P04635	Sumo-1 ligase	RAT|RGD=1306919|UniProtKB=Q5I0H3	Small ubiquitin-related modifier 1	ISS			PTHR10562:SF52	SMALL UBIQUITIN-RELATED MODIFIER 1
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	BOVIN|Ensembl=ENSBTAG00000039153|UniProtKB=F1MQE1	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF41	RIBOSOMAL PROTEIN S6 KINASE ALPHA-4
P04393	Ras Pathway	P04572	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00005	Angiogenesis	P00235	c-Fos	MACMU|Ensembl=ENSMMUG00000010574|UniProtKB=A5A6H2	C-fos	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00023	General transcription regulation	P00658	TBP-associated factors	ARATH|TAIR=AT1G04950|UniProtKB=Q9MAU3	Transcription initiation factor TFIID subunit 6	ISS	2196466	gi	PTHR10221:SF13	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MACMU|Ensembl=ENSMMUG00000000893|UniProtKB=F6T7D0	Histone acetyltransferase p300	ISS	10664585	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=109356|UniProtKB=O09044	Synaptosomal-associated protein 23	IC	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00005	Angiogenesis	P00243	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	3449797	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P04393	Ras Pathway	P04559	Rac	BOVIN|Gene=RAC1|UniProtKB=P62998	Ras-related C3 botulinum toxin substrate 1	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04398	p53 pathway feedback loops 2	P04664	cyclin E	DANRE|ZFIN=ZDB-GENE-980526-168|UniProtKB=P47794	G1/S-specific cyclin-E1	NAS	18858511	gi	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	CANLF|Ensembl=ENSCAFG00000002617|UniProtKB=E2QUL1	Uncharacterized protein	ISS	11554549	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00059	p53 pathway	P01486	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00010	B cell activation	P00367	NFAT	MOUSE|MGI=MGI=1920431|UniProtKB=Q8K120	Nuclear factor of activated T-cells, cytoplasmic 4	IDA	9462517	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	PANTR|Ensembl=ENSPTRG00000019361|UniProtKB=H2QUV3	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00059	p53 pathway	P01486	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00875	GEF	MOUSE|MGI=MGI=1334255|UniProtKB=P63034	Cytohesin-2	ISS	11747824	PubMed	PTHR43935:SF4	CYTOHESIN-2
P00021	FGF signaling pathway	P00624	14-3-3	HUMAN|HGNC=12851|UniProtKB=P62258	14-3-3 protein epsilon	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	TAKRU|Ensembl=ENSTRUG00000011169|UniProtKB=H2TU36	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00931	Integrin beta	MACMU|Ensembl=ENSMMUG00000002678|UniProtKB=F7HQ11	Integrin beta	ISS	3487386	PubMed	PTHR10082:SF11	INTEGRIN BETA-6
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	RCA	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05730	Endogenous cannabinoid signaling	P05746	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00030	Hypoxia response via HIF activation	P00819	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	TAS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000021900|UniProtKB=F1MFK1	Uncharacterized protein	ISS	11880265	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00018	EGF receptor signaling pathway	P00561	STAT	HUMAN|HGNC=11367|UniProtKB=P51692	Signal transducer and activator of transcription 5B	IGI	96210005	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	PANTR|Ensembl=ENSPTRG00000006510|UniProtKB=H2Q8K1	Presenilin	ISS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00036	Interleukin signaling pathway	P00981	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00912	Arp2/3	RAT|RGD=1311791|UniProtKB=Q4KLF8	Actin-related protein 2/3 complex subunit 5	ISS	12473693	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=1336171|UniProtKB=Q9DAS9	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00054	Toll receptor signaling pathway	P01358	ERK1	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00807	Actin	ORYSJ|EnsemblGenome=OS03G0718100|UniProtKB=Q10DV7	Actin-1	IDA	11889126	PubMed	PTHR11937:SF364	ACTIN-11
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000002016|UniProtKB=F1P3G1	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P06959	CCKR signaling map	P07180	CAS	HUMAN|HGNC=971|UniProtKB=P56945	Breast cancer anti-estrogen resistance protein 1	RCA	10354709	PubMed	PTHR10654:SF15	BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02781	Threonine biosynthesis	P03188	Homoserine dehydrogenase	METAC|EnsemblGenome=MA_2572|UniProtKB=Q8TMT0	Homoserine dehydrogenase	ISS			PTHR43331:SF1	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	IC	3045562	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	MOUSE|MGI=MGI=1890410|UniProtKB=Q9QXG4	Acetyl-coenzyme A synthetase, cytoplasmic	ISS			PTHR24095:SF126	ACETYL-COENZYME A SYNTHETASE, CYTOPLASMIC
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	RAT|RGD=619858|UniProtKB=P70579	Metabotropic glutamate receptor 8	IC	12488551	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P05918	p38 MAPK pathway	P06037	TAK1	CANLF|Ensembl=ENSCAFG00000003123|UniProtKB=E2R3R6	Uncharacterized protein	ISS	10683140	PubMed	PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P00029	Huntington disease	P00790	beta-Tubulin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g229095|UniProtKB=A7S027	Predicted protein	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	TAS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00019	Endothelin signaling pathway	P00573	signal peptidase	PANTR|Ensembl=ENSPTRG00000007404|UniProtKB=H2QA06	Signal peptidase complex catalytic subunit SEC11	ISS	2092035	PubMed	PTHR10806:SF8	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11A-RELATED
P04398	p53 pathway feedback loops 2	P04665	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05972	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00021	FGF signaling pathway	P00627	ERK1-2	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MACMU|Ensembl=ENSMMUG00000014807|UniProtKB=F6W548	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	ANOGA|EnsemblGenome=AGAP001712|UniProtKB=Q7PUF2	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000023940|UniProtKB=F6RFW8	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	ISS	10974003	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	IDA	9199552	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00018	EGF receptor signaling pathway	P00558	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00006	Apoptosis signaling pathway	P00260	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	IC	10974003	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04395	Vasopressin synthesis	P04597	Signal Peptide	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IGI	9516481	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MACMU|Ensembl=ENSMMUG00000000429|UniProtKB=F7ACJ7	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF165	BONE MORPHOGENETIC PROTEIN 4
P00056	VEGF signaling pathway	P01415	MAPKAPK2/3	CHICK|Ensembl=ENSGALG00000000883|UniProtKB=F1NCY7	Uncharacterized protein	ISS			PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00005	Angiogenesis	P00221	JNK1	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00057	Wnt signaling pathway	P01440	Cadherin	MONDO|Ensembl=ENSMODG00000010471|UniProtKB=F7ET26	Uncharacterized protein (Fragment)	ISS	8120095	PubMed	PTHR43912:SF3	PROTOCADHERIN-1
P00015	Circadian clock system	G01497	cry	CANLF|Ensembl=ENSCAFG00000009379|UniProtKB=F1PNC9	Uncharacterized protein	ISS	14507900	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	SCHPO|PomBase=SPAC6G9.11|UniProtKB=Q92356	Synaptobrevin homolog 1	ISS	8011337	PubMed	PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P02773	S-adenosylmethionine biosynthesis	P03142	Cobalamin-dependent homocysteine transmethylase	ECOLI|EcoGene=EG10587|UniProtKB=P13009	Methionine synthase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P00054	Toll receptor signaling pathway	P01361	TBK1	ORNAN|Ensembl=ENSOANG00000009917|UniProtKB=F6TM15	Uncharacterized protein	ISS			PTHR22969:SF14	SERINE/THREONINE-PROTEIN KINASE TBK1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	IDA	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANAL|CGD=CAL0068551|UniProtKB=Q5AAR9	Phosphatidylinositol 3-kinase	ISS	20330542	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	PANTR|Ensembl=ENSPTRG00000013825|UniProtKB=H2RAK4	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11463389	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00034	Integrin signalling pathway	P00924	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	HUMAN|HGNC=132|UniProtKB=P60709	Actin, cytoplasmic 1	IC	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00005	Angiogenesis	P00243	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00034	Integrin signalling pathway	P00919	Arf6	RAT|RGD=621279|UniProtKB=P62332	ADP-ribosylation factor 6	ISS	11752622	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P04393	Ras Pathway	P04557	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IDA	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	CHICK|Ensembl=ENSGALG00000008512|UniProtKB=F1P0S6	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P02736	Coenzyme A biosynthesis	P02886	Pantetheine-phosphate adenyltransferase	BACTN|EnsemblGenome=BT_3034|UniProtKB=Q8A3C0	Phosphopantetheine adenylyltransferase	ISS			PTHR21342:SF1	PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=11333|UniProtKB=P31391	Somatostatin receptor type 4	IDA	12181435	PubMed	PTHR24229:SF52	SOMATOSTATIN RECEPTOR TYPE 4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00010	B cell activation	P00397	IKK	CANLF|Ensembl=ENSCAFG00000009588|UniProtKB=E2RNA9	Uncharacterized protein	ISS	9346484	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MONDO|Ensembl=ENSMODG00000006737|UniProtKB=F7CDC6	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF90	FRIZZLED-8
P00053	T cell activation	P01305	Calmodulin	MONDO|Ensembl=ENSMODG00000002696|UniProtKB=F7CY56	Uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF335	CALMODULIN, STRIATED MUSCLE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00053	T cell activation	P01300	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000002016|UniProtKB=F1P3G1	Protein kinase C delta type	ISS	11880265	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00059	p53 pathway	P04616	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_114976|UniProtKB=C3YP58	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00048	PI3 kinase pathway	P01192	p110	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01205	NOS	MOUSE|MGI=MGI=97362|UniProtKB=P70313	Nitric oxide synthase, endothelial	ISS	22462730	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00017	DNA replication	P00533	Pol delta	RAT|RGD=621839|UniProtKB=O54747	DNA polymerase delta catalytic subunit	ISS	3122029	gi	PTHR10322:SF23	DNA POLYMERASE DELTA CATALYTIC SUBUNIT
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01146	Ikk	CANLF|Ensembl=ENSCAFG00000009588|UniProtKB=E2RNA9	Uncharacterized protein	RCA			PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000025373|UniProtKB=F6ZZG9	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00047	PDGF signaling pathway	P01167	Ets	BOVIN|Ensembl=ENSBTAG00000011001|UniProtKB=F6QFZ1	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF216	TRANSCRIPTIONAL REGULATOR ERG
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04398	p53 pathway feedback loops 2	P04658	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	IGI	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00038	JAK/STAT signaling pathway	P01034	Jak	MONDO|Ensembl=ENSMODG00000015373|UniProtKB=F6WH53	Tyrosine-protein kinase	ISS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00049	Parkinson disease	P01242	Casein kinase I	BOVIN|Ensembl=ENSBTAG00000016797|UniProtKB=A7MB90	CSNK1G2 protein	ISS	11437445	PubMed	PTHR11909:SF157	CASEIN KINASE I ISOFORM GAMMA-2
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	XENTR|Xenbase=XB-GENE-478850|UniProtKB=F6SV95	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF69	ACTIVIN RECEPTOR TYPE-1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00022	General transcription by RNA polymerase I	P00657	TBP	PANTR|Ensembl=ENSPTRG00000018624|UniProtKB=A6H914	TATA box binding protein-like 1	ISS	10082669	PubMed	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00583	cPLA2	CANLF|Ensembl=ENSCAFG00000013778|UniProtKB=F6UQ33	Phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00060	Ubiquitin proteasome pathway	P01491	E2	TRYB2|Gene=Tb927.5.1000|UniProtKB=Q57W45	Ubiquitin-conjugating enzyme E2, putative	ISS			PTHR24068:SF74	FI16911P1-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04413	K+ channel	MOUSE|MGI=MGI=1100509|UniProtKB=O35111	Potassium channel subfamily K member 3	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00005	Angiogenesis	P00236	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	ISS	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P00046	Oxidative stress response	P01129	JNK1/2	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00048	PI3 kinase pathway	P01202	p85	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	RCA	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	RAT|RGD=1310557|UniProtKB=F1LNW1	Protein Rbpj	ISS	15187023	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00036	Interleukin signaling pathway	P00980	IRS1/2	MACMU|Ensembl=ENSMMUG00000019467|UniProtKB=F6SUL3	Uncharacterized protein	ISS	5031805	gi	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	HUMAN|HGNC=3014|UniProtKB=Q16555	Dihydropyrimidinase-related protein 2	TAS	7637782	PubMed	PTHR11647:SF56	DIHYDROPYRIMIDINASE-RELATED PROTEIN 2
P00012	Cadherin signaling pathway	P00474	Wnt	PANTR|Ensembl=ENSPTRG00000002849|UniProtKB=H2Q2F4	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	CHICK|Ensembl=ENSGALG00000007509|UniProtKB=F1NM72	Uncharacterized protein	ISS	87005246	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	11956331	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DROME|FlyBase=FBgn0003093|UniProtKB=P13678	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00053	T cell activation	P01310	Lck	MOUSE|MGI=MGI=96756|UniProtKB=P06240	Proto-oncogene tyrosine-protein kinase LCK	ISS	1505025	PubMed	PTHR24418:SF39	TYROSINE-PROTEIN KINASE LCK
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CAEBR|Gene=CBG11357|UniProtKB=A8XD73	Protein CBR-MYO-5	ISS			PTHR13140:SF398	MYOSIN HEAVY CHAIN STRUCTURAL GENES
P00005	Angiogenesis	P00189	Fzd	PANTR|Ensembl=ENSPTRG00000028511|UniProtKB=H2R570	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF81	FRIZZLED-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04558	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	IDA	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00053	T cell activation	P01319	PAK	CHICK|Ensembl=ENSGALG00000008058|UniProtKB=F1N8W8	Uncharacterized protein	ISS	7559398	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00034	Integrin signalling pathway	P00951	Jnk	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=2685563|UniProtKB=Q80TF3	Protocadherin-19	ISS	8120095	PubMed	PTHR24028:SF40	PROTOCADHERIN-19
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IGI	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	3045562	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P06587	Nicotine pharmacodynamics pathway	P06592	CHRNA6	HUMAN|HGNC=15963|UniProtKB=Q15825	Neuronal acetylcholine receptor subunit alpha-6	TAS	85270494	PubMed	PTHR18945:SF82	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-6
P00056	VEGF signaling pathway	P01423	p38MAPK	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05731	GABA-B receptor II signaling	P05752	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00807	Actin	XENTR|Xenbase=XB-GENE-493937|UniProtKB=Q5M8T9	Actin, alpha 2, smooth muscle, aorta	ISS	10974003	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00006	Apoptosis signaling pathway	P00317	Fos	MACMU|Ensembl=ENSMMUG00000010574|UniProtKB=A5A6H2	C-fos	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	RAT|RGD=69651|UniProtKB=P38438	TGF-beta receptor type-2	TAS	9759503	PubMed	PTHR23255:SF55	TGF-BETA RECEPTOR TYPE-2
P00021	FGF signaling pathway	P00646	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	20908895	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04393	Ras Pathway	P04557	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	TAS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00021	FGF signaling pathway	P00643	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	SCHMA|EnsemblGenome=Smp_079960|UniProtKB=G4VTA4	Putative tubulin beta chain	ISS	9454836	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00018	EGF receptor signaling pathway	P00564	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12912997	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00056	VEGF signaling pathway	P01411	Ras	MONDO|Gene=KRAS|UniProtKB=Q07983	GTPase KRas	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00046	Oxidative stress response	P01134	cPLA2	ORNAN|Ensembl=ENSOANG00000001027|UniProtKB=F6QDY0	Phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00045	Notch signaling pathway	P01119	NIct	PANTR|Ensembl=ENSPTRG00000010617|UniProtKB=H2QFL8	Notch 3	ISS	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00036	Interleukin signaling pathway	P00975	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00005	Angiogenesis	P00226	Delta/Serrate	CANLF|Ensembl=ENSCAFG00000009401|UniProtKB=E2R9U3	Delta-like protein	ISS	11798067	PubMed	PTHR24044:SF320	DELTA-LIKE PROTEIN 4
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05913	Enkephalin release	G06045	preproenkephalin	DANRE|ZFIN=ZDB-GENE-030729-31|UniProtKB=A8E7S2	Uncharacterized protein	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=3023|UniProtKB=P14416	D(2) dopamine receptor	IDA	2039532	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P02738	De novo purine biosynthesis	P02902	ADP reductase	DEIRA|EnsemblGenome=DR_B0109|UniProtKB=Q9RZL6	Ribonucleoside-diphosphate reductase, beta chain	ISS			PTHR23409:SF32	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT BETA
P00005	Angiogenesis	P00236	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00566	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MACMU|Ensembl=ENSMMUG00000010743|UniProtKB=F7G171	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF76	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	HUMAN|HGNC=4572|UniProtKB=P42262	Glutamate receptor 2	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00010	B cell activation	P00383	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IDA	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000006289|UniProtKB=H2Q875	Uncharacterized protein	ISS	12181435	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MOUSE|MGI=MGI=101848|UniProtKB=P62881	Guanine nucleotide-binding protein subunit beta-5	ISS	9754712	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00018	EGF receptor signaling pathway	P00539	14-3-3	RAT|RGD=62000|UniProtKB=P62260	14-3-3 protein epsilon	ISS	9450960	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P02769	Purine metabolism	P03119	5'-Nucleotidase	MACMU|Ensembl=ENSMMUG00000005442|UniProtKB=F7GPZ7	Uncharacterized protein	ISS	3219501	gi	PTHR11575:SF25	5'-NUCLEOTIDASE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00005	Angiogenesis	P00251	cPLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00049	Parkinson disease	P01236	Casein kinase II	SCHPO|PomBase=SPAC23C11.11|UniProtKB=P40231	Casein kinase II subunit alpha	IDA	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P02723	Adenine and hypoxanthine salvage pathway	P02812	Deoxyinosine phosphorylase	DROME|FlyBase=FBgn0035348|UniProtKB=M9PE19	Uncharacterized protein, isoform H	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00012	Cadherin signaling pathway	P00467	alpha-catenin	CHICK|Gene=CTNNA2|UniProtKB=P30997	Catenin alpha-2	IDA	1768802	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P00053	T cell activation	P01311	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	PANTR|Ensembl=ENSPTRG00000003383|UniProtKB=H2Q376	Uncharacterized protein	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P06959	CCKR signaling map	P07019	RHOA-GDP	HUMAN|HGNC=667|UniProtKB=P61586	Transforming protein RhoA	RCA	12771155	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00010	B cell activation	P00377	Ig-beta	MOUSE|MGI=MGI=96431|UniProtKB=P15530	B-cell antigen receptor complex-associated protein beta chain	IDA	11136817	PubMed	PTHR14334:SF2	B-CELL ANTIGEN RECEPTOR COMPLEX-ASSOCIATED PROTEIN BETA CHAIN
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	TAS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05913	Enkephalin release	P05972	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PANTR|Ensembl=ENSPTRG00000023525|UniProtKB=H2R1E3	Uncharacterized protein	ISS			PTHR13140:SF706	UNCONVENTIONAL MYOSIN-VI
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00047	PDGF signaling pathway	P01163	c-Jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00006	Apoptosis signaling pathway	P00260	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IDA	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MACMU|Ensembl=ENSMMUG00000010904|UniProtKB=F7GLY5	Uncharacterized protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P02748	Isoleucine biosynthesis	P02998	Dihydroxyacid dehydratase	BACTN|EnsemblGenome=BT_2078|UniProtKB=Q8A608	Dihydroxy-acid dehydratase	ISS			PTHR43661:SF3	DIHYDROXY-ACID DEHYDRATASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	CHICK|Gene_ORFName=RCJMB04_14g1|UniProtKB=Q5F3L1	Ribosomal protein S6 kinase alpha-5	ISS	6755374	gi	PTHR24351:SF115	RIBOSOMAL PROTEIN S6 KINASE ALPHA-5
P00056	VEGF signaling pathway	P01414	PLC-gamma	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00045	Notch signaling pathway	P01101	Su(H)	CHICK|Ensembl=ENSGALG00000014365|UniProtKB=F1NIJ8	Uncharacterized protein	ISS	12145413	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00053	T cell activation	P01296	TCR zeta	MACMU|Ensembl=ENSMMUG00000008158|UniProtKB=F7HE20	Uncharacterized protein	ISS	9012833	PubMed	PTHR10035:SF2	T-CELL SURFACE GLYCOPROTEIN CD3 ZETA CHAIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	PANTR|Ensembl=ENSPTRG00000004525|UniProtKB=H2Q572	Uncharacterized protein	ISS			PTHR16290:SF5	MRNA-DECAPPING ENZYME 1B
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00010	B cell activation	P00381	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01211	ERK	ARATH|TAIR=AT1G59580|UniProtKB=Q39022	Mitogen-activated protein kinase 2	IDA	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00053	T cell activation	P01305	Calmodulin	STRPU|EnsemblGenome=SPU_005033|UniProtKB=W4XNQ0	Uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF263	SUBFAMILY NOT NAMED
P02736	Coenzyme A biosynthesis	P02885	Pantothenate kinase	PANTR|Ensembl=ENSPTRG00000013211|UniProtKB=H2R312	Uncharacterized protein	ISS			PTHR12280:SF25	PANTOTHENATE KINASE 2, MITOCHONDRIAL
P00034	Integrin signalling pathway	P00936	PI3K	DROME|FlyBase=FBgn0020622|UniProtKB=Q7KTZ2	Pi3K21B, isoform B	IPI	7937853	PubMed	PTHR10155:SF0	PI3K21B, ISOFORM B
P00009	Axon guidance mediated by netrin	P00363	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00045	Notch signaling pathway	P01119	NIct	MOUSE|MGI=MGI=107471|UniProtKB=P31695	Neurogenic locus notch homolog protein 4	ISS	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P05918	p38 MAPK pathway	P05921	MKP5	ORNAN|Ensembl=ENSOANG00000001437|UniProtKB=F7GDU1	Uncharacterized protein	ISS	10597297	PubMed	PTHR10159:SF299	DUAL SPECIFICITY PROTEIN PHOSPHATASE 10
P05730	Endogenous cannabinoid signaling	P05751	Galpha	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05730	Endogenous cannabinoid signaling	P05748	mGluR	RAT|RGD=2746|UniProtKB=P31424	Metabotropic glutamate receptor 5	ISS	7476890	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00034	Integrin signalling pathway	P00925	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02751	Lysine biosynthesis	P03013	Aspartate semialdehyde dehydrogenase	RHOBA|EnsemblGenome=RB9795|UniProtKB=Q7UL17	Aspartate-semialdehyde dehydrogenase	ISS			PTHR10174:SF2	ASPARTATE-SEMIALDEHYDE DEHYDROGENASE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00053	T cell activation	P01336	Jnk	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000011757|UniProtKB=Q9XT97	Presenilin-1	IDA	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00056	VEGF signaling pathway	P01415	MAPKAPK2/3	MOUSE|MGI=MGI=2143163|UniProtKB=Q3UMW7	MAP kinase-activated protein kinase 3	ISS	11335727	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00255	Notch	HUMAN|HGNC=7884|UniProtKB=Q99466	Neurogenic locus notch homolog protein 4	ISS	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P00058	mRNA splicing	P01473	U6	PANTR|Ensembl=ENSPTRG00000001254|UniProtKB=G2HGL9	PRP3 pre-mRNA processing factor 3 homolog	ISS	9328476	PubMed	PTHR14212:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PHYPA|Gene=PHYPADRAFT_109052|UniProtKB=A9TZ58	Actin 5	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00048	PI3 kinase pathway	P01177	P110ACT	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	ARATH|TAIR=AT4G34460|UniProtKB=P49177	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF48	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA
P00005	Angiogenesis	P00216	Caspase 9	HUMAN|HGNC=1511|UniProtKB=P55211	Caspase-9	IDA	9390557	PubMed	PTHR10454:SF157	CASPASE-9
P00018	EGF receptor signaling pathway	P00555	MKK4,7	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	18021322	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02781	Threonine biosynthesis	P03189	Aspartate kinase	BACTN|EnsemblGenome=BT_1901|UniProtKB=Q8A6I3	Lysine-sensitive aspartokinase III	ISS			PTHR21499:SF38	ASPARTOKINASE 1, CHLOROPLASTIC
P00034	Integrin signalling pathway	P00925	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	XENTR|Xenbase=XB-GENE-6469705|UniProtKB=Q6P8G3	Actin, alpha sarcomeric/skeletal	ISS	11889126	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01471	alpha-catenin	HUMAN|HGNC=2512|UniProtKB=Q9UBT7	Alpha-catulin	IDA	9362521	PubMed	PTHR18914:SF8	ALPHA-CATULIN
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Gene=HTR1A|UniProtKB=Q9N298	5-hydroxytryptamine receptor 1A	IDA	12441358	PubMed	PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P00029	Huntington disease	P00780	Microtubule	ORYSJ|EnsemblGenome=OS01G0805900|UniProtKB=P45960	Tubulin beta-4 chain	IDA	9454836	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00706	RGS-PX1	PANTR|Ensembl=ENSPTRG00000018957|UniProtKB=H2QU81	Uncharacterized protein	ISS	11729322	PubMed	PTHR22775:SF30	SORTING NEXIN-13
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	ISS	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01448	CBP	ARATH|TAIR=AT1G67220|UniProtKB=Q9FYH1	Histone acetyltransferase HAC2	IDA	8413673	PubMed	PTHR13808:SF6	HISTONE ACETYLTRANSFERASE HAC2
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00200	Dsh	MOUSE|MGI=MGI=108100|UniProtKB=Q61062	Segment polarity protein dishevelled homolog DVL-3	ISS	11212302	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	IDA	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	YEAST|SGD=S000000028|UniProtKB=P31109	Synaptobrevin homolog 1	ISS	88248054	PubMed	PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	ARATH|TAIR=AT3G18780|UniProtKB=Q96292	Actin-2	IC	11889126	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P05913	Enkephalin release	P05973	GPCR (i)	DANRE|ZFIN=ZDB-GENE-990415-199|UniProtKB=A3QJX7	Uncharacterized protein	ISS	12093103	PubMed	PTHR24229:SF74	SUBFAMILY NOT NAMED
P00054	Toll receptor signaling pathway	P01360	IKKbeta	PANTR|Ensembl=ENSPTRG00000020202|UniProtKB=H2QW34	Uncharacterized protein	ISS	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00010	B cell activation	P00392	I kappa B	PANTR|Ensembl=ENSPTRG00000006265|UniProtKB=H2Q867	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	ISS	14665694	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P02749	Leucine biosynthesis	P03002	Isopropylmalate isomerase	THEMA|EnsemblGenome=TM_0291|UniProtKB=Q9WYC7	3-isopropylmalate dehydratase large subunit 1	ISS			PTHR43822:SF2	HOMOACONITASE, MITOCHONDRIAL
P00010	B cell activation	P00392	I kappa B	RAT|RGD=3171|UniProtKB=Q63746	NF-kappa-B inhibitor alpha	ISS	10811867	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	HUMAN|HGNC=711|UniProtKB=P49407	Beta-arrestin-1	IDA	4757780	gi	PTHR11792:SF22	BETA-ARRESTIN-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	188830	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01151	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00219	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00010	B cell activation	P00375	Calmodulin	CANLF|Ensembl=ENSCAFG00000030049|UniProtKB=J9NWQ5	Uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF311	CALMODULIN
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02786	Vitamin B6 biosynthesis	P03225	1-Deoxyxylulose-5-phosphate synthase	MYCTU|EnsemblGenome=Rv2682c|UniProtKB=P9WNS3	1-deoxy-D-xylulose-5-phosphate synthase	ISS			PTHR43322:SF6	1-DEOXY-D-XYLULOSE-5-PHOSPHATE SYNTHASE
P00006	Apoptosis signaling pathway	P00302	ATF	PANTR|Ensembl=ENSPTRG00000004941|UniProtKB=H2Q5X1	Activating transcription factor 1	ISS	11390664	PubMed	PTHR22952:SF258	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-1
P00018	EGF receptor signaling pathway	P00561	STAT	CANLF|Ensembl=ENSCAFG00000015213|UniProtKB=E2RB82	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01161	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00029	Huntington disease	P00777	CBP	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008422|UniProtKB=F6VUT7	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00562	p38	CAEEL|WormBase=WBGene00004055|UniProtKB=Q17446	Mitogen-activated protein kinase pmk-1	IGI	10514528	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00019	Endothelin signaling pathway	P00566	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00539	14-3-3	BOVIN|Ensembl=ENSBTAG00000005664|UniProtKB=P62261	14-3-3 protein epsilon	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00021	FGF signaling pathway	P00627	ERK1-2	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04657	P110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04397	p53 pathway by glucose deprivation	P04644	TSC2	PANTR|Ensembl=ENSPTRG00000031311|UniProtKB=H2R1U8	Uncharacterized protein	ISS	15249583	PubMed	PTHR10063:SF0	TUBERIN
P06587	Nicotine pharmacodynamics pathway	P06605	KCNK3/9	HUMAN|HGNC=6278|UniProtKB=O14649	Potassium channel subfamily K member 3	RCA	11875121	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00010	B cell activation	P00402	Jnk	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00052	TGF-beta signaling pathway	P01275	P38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	TAS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04377	Beta1 adrenergic receptor signaling pathway	P04433	Beta1	HUMAN|HGNC=285|UniProtKB=P08588	Beta-1 adrenergic receptor	ISS	12730078	PubMed	PTHR24248:SF54	BETA-1 ADRENERGIC RECEPTOR
P00017	DNA replication	P00527	Histones	STRPU|EnsemblGenome=SPU_027750|UniProtKB=W4ZHT8	Histone H3	ISS	12413958	PubMed	PTHR11426:SF20	HISTONE H3-LIKE CENTROMERIC PROTEIN A
P00057	Wnt signaling pathway	P01471	alpha-catenin	BOVIN|Gene=CTNNA1|UniProtKB=Q3MHM6	Catenin alpha-1	ISS	1768802	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P02723	Adenine and hypoxanthine salvage pathway	P02809	Xanthine dehydrogenase	HUMAN|HGNC=12805|UniProtKB=P47989	Xanthine dehydrogenase/oxidase	ISS	4336760	gi	PTHR11908:SF80	XANTHINE DEHYDROGENASE/OXIDASE
P00020	FAS signaling pathway	P00594	Caspase8	HUMAN|HGNC=1876|UniProtKB=O15519	CASP8 and FADD-like apoptosis regulator	IGI	9228018	PubMed	PTHR10454:SF8	CASP8 AND FADD-LIKE APOPTOSIS REGULATOR
P00037	Ionotropic glutamate receptor pathway	P01026	KA	CHICK|Ensembl=ENSGALG00000002098|UniProtKB=F1P0L4	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P04393	Ras Pathway	P04556	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01438	PP2A	BOVIN|Ensembl=ENSBTAG00000000469|UniProtKB=P67774	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02734	Chorismate biosynthesis	P02871	2-Deoxy-7-phosphoheptulonate synthase	SCHPO|PomBase=SPAC24H6.10c|UniProtKB=Q09755	Putative phospho-2-dehydro-3-deoxyheptonate aldolase	ISS			PTHR21225:SF0	PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, TYROSINE-INHIBITED
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00021	FGF signaling pathway	P00629	PP2A	MACMU|Ensembl=ENSMMUG00000008205|UniProtKB=F7GWP9	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	ISS	11007767	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00005	Angiogenesis	P00214	HIF-1	PANTR|Ensembl=ENSPTRG00000006419|UniProtKB=H2Q8F3	Uncharacterized protein	ISS	9606183	PubMed	PTHR23043:SF7	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA
P00013	Cell cycle	P00480	Proteasome	RAT|RGD=1306902|UniProtKB=D4AEH3	Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 7 (Predicted)	ISS	95275316	PubMed	PTHR10540:SF7	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=69430|UniProtKB=P32851	Syntaxin-1A	IC	1321498	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00047	PDGF signaling pathway	P01162	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MACMU|Ensembl=ENSMMUG00000014689|UniProtKB=F7GTT9	Uncharacterized protein	ISS			PTHR13140:SF417	UNCONVENTIONAL MYOSIN-ID
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01153	GSK3	MACMU|Ensembl=ENSMMUG00000014597|UniProtKB=F6VAQ6	Glycogen synthase kinase-3 alpha	ISS	14698990	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P02738	De novo purine biosynthesis	P02907	dADP kinase	HUMAN|HGNC=7852|UniProtKB=O00746	Nucleoside diphosphate kinase, mitochondrial	ISS			PTHR11349:SF49	NUCLEOSIDE DIPHOSPHATE KINASE, MITOCHONDRIAL
P00019	Endothelin signaling pathway	P00581	Guanylate cyclase	RAT|RGD=621655|UniProtKB=Q9WVI4	Guanylate cyclase soluble subunit alpha-2	RCA			PTHR11920:SF276	GUANYLATE CYCLASE SOLUBLE SUBUNIT ALPHA-2
P00018	EGF receptor signaling pathway	P00558	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00057	Wnt signaling pathway	P01444	Wnt	RAT|RGD=69079|UniProtKB=M0R9D3	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=62388|UniProtKB=P35365	5-hydroxytryptamine receptor 5B	IDA	12181435	PubMed	PTHR24247:SF14	5-HYDROXYTRYPTAMINE RECEPTOR 5B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	IDA	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00019	Endothelin signaling pathway	P00566	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9836512	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	CHICK|Ensembl=ENSGALG00000017238|UniProtKB=F1NWG3	Uncharacterized protein	ISS	7476890	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00010	B cell activation	P00373	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	CANLF|Ensembl=ENSCAFG00000015213|UniProtKB=E2RB82	Signal transducer and activator of transcription	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_114535|UniProtKB=C3ZHN2	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01199	Galpha	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05913	Enkephalin release	P05974	G-Protein (i)	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04393	Ras Pathway	P04547	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00005	Angiogenesis	P00223	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00551	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CAEBR|Gene=CBG05858|UniProtKB=A8X1H0	Protein CBR-EGL-19 (Fragment)	ISS	8838325	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000004474|UniProtKB=E2RCN6	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00010	B cell activation	P00386	Calcineurin	MOUSE|MGI=MGI=107164|UniProtKB=P63328	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	ISS	7532676	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000000771|UniProtKB=F6SSS3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00006	Apoptosis signaling pathway	P00321	HSP70	MOUSE|MGI=MGI=105384|UniProtKB=P63017	Heat shock cognate 71 kDa protein	ISS	12150907	PubMed	PTHR19375:SF239	HEAT SHOCK COGNATE 71 KDA PROTEIN
P04393	Ras Pathway	P04558	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00060	Ubiquitin proteasome pathway	P01492	E1	BOVIN|Ensembl=ENSBTAG00000016764|UniProtKB=A3KMV5	Ubiquitin-like modifier-activating enzyme 1	ISS			PTHR10953:SF155	UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 1
P00048	PI3 kinase pathway	P01182	Ras	DANRE|ZFIN=ZDB-GENE-990415-166|UniProtKB=P79737	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00050	Plasminogen activating cascade	P01249	pro-tPA	PANTR|Ensembl=ENSPTRG00000020201|UniProtKB=H2QW33	Tissue-type plasminogen activator	ISS	6572897	PubMed	PTHR44617:SF1	TISSUE-TYPE PLASMINOGEN ACTIVATOR
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CANLF|Ensembl=ENSCAFG00000005662|UniProtKB=E2R907	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	ORYSJ|EnsemblGenome=OS01G0872800|UniProtKB=Q8RUE8	Os01g0872800 protein	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00020	FAS signaling pathway	P00615	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	YEAST|SGD=S000001295|UniProtKB=P07278	cAMP-dependent protein kinase regulatory subunit	ISS	176892	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00373	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00018	EGF receptor signaling pathway	P00539	14-3-3	RAT|RGD=3980|UniProtKB=P63102	14-3-3 protein zeta/delta	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00049	Parkinson disease	P01235	Fyn kinase	PANTR|Ensembl=ENSPTRG00000018511|UniProtKB=H2QTK7	Tyrosine-protein kinase	ISS	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01174	Rho	HUMAN|HGNC=8148|UniProtKB=O60890	Oligophrenin-1	ISS			PTHR12552:SF2	OLIGOPHRENIN-1
P05916	Opioid prodynorphin pathway	P06002	G-protein	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04393	Ras Pathway	P04552	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00034	Integrin signalling pathway	P00927	Rac	DICDI|dictyBase=DDB_G0279605|UniProtKB=P34148	Rho-related protein racB	IGI	94124042	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00047	PDGF signaling pathway	P01150	PKC	RAT|RGD=620146|UniProtKB=O08874	Serine/threonine-protein kinase N2	ISS	10644715	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P02746	Heme biosynthesis	P02983	Hydroxymethylbilane synthase	METAC|EnsemblGenome=MA_0582|UniProtKB=Q8TT56	Probable porphobilinogen deaminase	ISS			PTHR11557:SF0	PORPHOBILINOGEN DEAMINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	10218114	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00021	FGF signaling pathway	P00648	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	87218499	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	PANTR|Ensembl=ENSPTRG00000018059|UniProtKB=C7G3M9	Glutamate receptor, metabotropic 4	ISS			PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	XENTR|Xenbase=XB-GENE-969447|UniProtKB=Q0IIR4	Tubulin, beta 2C	ISS	9454836	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	BOVIN|Gene=CACNB1|UniProtKB=Q9MZL7	Voltage-dependent L-type calcium channel subunit beta-1	IC	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00036	Interleukin signaling pathway	P00973	PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04570	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00211	GSK3beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04393	Ras Pathway	P04557	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IDA	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00059	p53 pathway	P04609	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00977	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P05913	Enkephalin release	P05974	G-Protein (i)	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	XENTR|Xenbase=XB-GENE-5752629|UniProtKB=F6UBB9	Uncharacterized protein	ISS	11438518	PubMed	PTHR10024:SF239	SYNAPTOTAGMIN-1
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	MACMU|Ensembl=ENSMMUG00000017932|UniProtKB=F7EMD9	Acetyl-coenzyme A synthetase, cytoplasmic	ISS			PTHR24095:SF126	ACETYL-COENZYME A SYNTHETASE, CYTOPLASMIC
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	IC	91298951	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00029	Huntington disease	P00778	NMDA receptor	RAT|RGD=2736|UniProtKB=P35439	Glutamate receptor ionotropic, NMDA 1	IDA	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00018	EGF receptor signaling pathway	P00564	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00964	p90RSK	BOVIN|Ensembl=ENSBTAG00000014447|UniProtKB=A4IFF4	Ribosomal protein S6 kinase	ISS	7688567	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_127490|UniProtKB=C3XYC5	Putative uncharacterized protein	IDA	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	XENTR|Xenbase=XB-GENE-961764|UniProtKB=F6W3Y0	Uncharacterized protein	ISS	7559398	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P06587	Nicotine pharmacodynamics pathway	P06602	PPP1CA	MOUSE|MGI=MGI=103016|UniProtKB=P62137	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit	TAS	10433257	PubMed	PTHR11668:SF377	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-ALPHA CATALYTIC SUBUNIT
P04393	Ras Pathway	P04558	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00034	Integrin signalling pathway	P00943	Talin	DROME|FlyBase=FBgn0260442|UniProtKB=Q9VSL8	Rhea, isoform B	IPI	14702644	PubMed	PTHR19981:SF1	TALIN-2
P00053	T cell activation	P01294	NFAT	HUMAN|HGNC=7777|UniProtKB=Q12968	Nuclear factor of activated T-cells, cytoplasmic 3	IGI	9133421	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00021	FGF signaling pathway	P00642	MEK1-2	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	RCA	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00029	Huntington disease	P00775	Rac	ENTHI|EnsemblGenome=EHI_181250|UniProtKB=C4M5Z7	Rho family GTPase	TAS			PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	HUMAN|HGNC=130|UniProtKB=P62736	Actin, aortic smooth muscle	IC	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P04393	Ras Pathway	P04559	Rac	DANRE|ZFIN=ZDB-GENE-080220-21|UniProtKB=A9JRY8	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01179	PKB	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	XENTR|Xenbase=XB-GENE-494548|UniProtKB=F7EC26	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000010521|UniProtKB=F7DQK7	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	ANOGA|EnsemblGenome=AGAP002440|UniProtKB=Q17031	Cdc42 homolog	ISS	4757952	gi	PTHR24072:SF192	CDC42 HOMOLOG
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00036	Interleukin signaling pathway	P00983	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00047	PDGF signaling pathway	P01159	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MACMU|Ensembl=ENSMMUG00000007027|UniProtKB=F7F210	Alpha-cardiac actin	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	21150461	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04393	Ras Pathway	P04542	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00023	General transcription regulation	P00662	TFIIA complex	XENTR|Xenbase=XB-GENE-990822|UniProtKB=Q6DEQ4	Transcription initiation factor IIA subunit 2	ISS			PTHR10966:SF0	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2
P00006	Apoptosis signaling pathway	P00271	Bax	BOVIN|Ensembl=ENSBTAG00000013340|UniProtKB=O02703	Apoptosis regulator BAX	ISS	11099028	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P04393	Ras Pathway	P04572	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00644	p38	DROME|FlyBase=FBgn0015765|UniProtKB=O62618	Mitogen-activated protein kinase 14A	IGI	11274345	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00056	VEGF signaling pathway	P01414	PLC-gamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00807	Actin	ORNAN|Ensembl=ENSOANG00000007716|UniProtKB=F6UDX9	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00021	FGF signaling pathway	P00647	SHP2	MOUSE|MGI=MGI=96055|UniProtKB=P29351	Tyrosine-protein phosphatase non-receptor type 6	ISS	14525967	PubMed	PTHR19134:SF65	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 6
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	ARATH|TAIR=AT3G08510|UniProtKB=Q39033	Phosphoinositide phospholipase C 2	ISS			PTHR10336:SF92	PHOSPHOINOSITIDE PHOSPHOLIPASE C 2-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00004	Alzheimer disease-presenilin pathway	P00148	Erb-B4 N-terminal fragment	MONDO|Ensembl=ENSMODG00000015755|UniProtKB=F6ZSZ9	Uncharacterized protein (Fragment)	ISS	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00047	PDGF signaling pathway	P01154	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	TAKRU|Ensembl=ENSTRUG00000008685|UniProtKB=H2TXN3	Uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF326	CALMODULIN
P00034	Integrin signalling pathway	P00947	Laminin	HUMAN|HGNC=6483|UniProtKB=Q16787	Laminin subunit alpha-3	IPI	2538453	PubMed	PTHR10574:SF285	LAMININ SUBUNIT ALPHA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MACMU|Ensembl=ENSMMUG00000009607|UniProtKB=F7A586	5-hydroxytryptamine receptor 2C	ISS			PTHR24247:SF32	5-HYDROXYTRYPTAMINE RECEPTOR 2C
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00056	VEGF signaling pathway	P01407	Erk	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00020	FAS signaling pathway	P00601	c-Jun	CHICK|Gene=JUN|UniProtKB=P18870	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00036	Interleukin signaling pathway	P00964	p90RSK	MOUSE|MGI=MGI=104558|UniProtKB=P18653	Ribosomal protein S6 kinase alpha-1	IGI	12213813	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P02723	Adenine and hypoxanthine salvage pathway	P02810	Adenine phosphoribosyl transferase	ANOGA|EnsemblGenome=AGAP005723|UniProtKB=Q7Q6Q8	AGAP005723-PA	ISS			PTHR32315:SF3	ADENINE PHOSPHORIBOSYLTRANSFERASE
P02741	Flavin biosynthesis	P02936	FAD synthetase	HUMAN|HGNC=30324|UniProtKB=Q969G6	Riboflavin kinase	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P00001	Adrenaline and noradrenaline biosynthesis	P00067	MAO	XENTR|Xenbase=XB-GENE-5749883|UniProtKB=F6V922	Uncharacterized protein (Fragment)	ISS	8602220	PubMed	PTHR43563:SF2	AMINE OXIDASE  FLAVIN-CONTAINING
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00047	PDGF signaling pathway	P01150	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01417	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00625	MKK3,6	CANLF|Ensembl=ENSCAFG00000010758|UniProtKB=E2R7W7	Uncharacterized protein	RCA			PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01455	Smad4	RAT|RGD=620158|UniProtKB=Q9R1V3	Mothers against decapentaplegic homolog 5	ISS	9395284	PubMed	PTHR13703:SF36	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5
P00048	PI3 kinase pathway	P01189	PTEN	XENTR|Xenbase=XB-GENE-491433|UniProtKB=B1H2U0	Pten protein	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00057	Wnt signaling pathway	P01430	p53	HUMAN|HGNC=11998|UniProtKB=P04637	Cellular tumor antigen p53	IDA	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P06959	CCKR signaling map	G07295	VMAT2	HUMAN|HGNC=10935|UniProtKB=Q05940	Synaptic vesicular amine transporter	RCA	17442673	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00045	Notch signaling pathway	P01119	NIct	MACMU|Ensembl=ENSMMUG00000017022|UniProtKB=F7HQZ9	Uncharacterized protein	ISS	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00036	Interleukin signaling pathway	P00996	STAT	PANTR|Ensembl=ENSPTRG00000005095|UniProtKB=H2Q688	Signal transducer and activator of transcription	ISS			PTHR11801:SF41	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 2
P04398	p53 pathway feedback loops 2	P04654	Rb	MOUSE|MGI=MGI=103300|UniProtKB=Q64701	Retinoblastoma-like protein 1	ISS			PTHR13742:SF20	RETINOBLASTOMA-LIKE PROTEIN 1
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IGI	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00018	EGF receptor signaling pathway	P00552	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MACMU|Ensembl=ENSMMUG00000014807|UniProtKB=F6W548	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00034	Integrin signalling pathway	P00920	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00036	Interleukin signaling pathway	P00990	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00059	p53 pathway	P04630	PP2A	HUMAN|HGNC=9299|UniProtKB=P67775	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00023	General transcription regulation	P00668	TFIIB	CANAL|CGD=CAL0000177227|UniProtKB=P43072	Transcription factor IIIB 70 kDa subunit	ISS			PTHR11618:SF4	TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT
P00034	Integrin signalling pathway	P00951	Jnk	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04397	p53 pathway by glucose deprivation	P04641	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MOUSE|MGI=MGI=87909|UniProtKB=P62737	Actin, aortic smooth muscle	IDA	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00004	Alzheimer disease-presenilin pathway	P00114	actin	HUMAN|HGNC=17780|UniProtKB=Q562R1	Beta-actin-like protein 2	IDA	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	PANTR|Ensembl=ENSPTRG00000000387|UniProtKB=H2PYE3	Ribosomal protein S6 kinase	ISS	7688567	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	93028473	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00034	Integrin signalling pathway	P00944	Actin	MONDO|Ensembl=ENSMODG00000024992|UniProtKB=F6TUR3	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	ISS	88234494	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00007	Axon guidance mediated by semaphorins	P00341	Rho	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	ISS	12169092	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00037	Ionotropic glutamate receptor pathway	P01023	CaMKII	BOVIN|Ensembl=ENSBTAG00000020087|UniProtKB=Q08E45	Calcium/calmodulin-dependent protein kinase II alpha	ISS	12888804	PubMed	PTHR43940:SF5	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	HUMAN|HGNC=9995|UniProtKB=O14921	Regulator of G-protein signaling 13	IDA	8756726	PubMed	PTHR10845:SF32	REGULATOR OF G-PROTEIN SIGNALING 13
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	BOVIN|Ensembl=ENSBTAG00000012046|UniProtKB=Q0VBZ5	Transcription factor jun-B	ISS	10664585	PubMed	PTHR11462:SF37	TRANSCRIPTION FACTOR JUN-B
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00887	IRS 1-4	CANLF|Ensembl=ENSCAFG00000010397|UniProtKB=E2RDB5	Uncharacterized protein	ISS	15110093	PubMed	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00021	FGF signaling pathway	P00634	MEKK1-5	MACMU|Ensembl=ENSMMUG00000018568|UniProtKB=F6YLW2	Uncharacterized protein	ISS	21735556	gi	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00238	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BOVIN|Gene=ACTG2|UniProtKB=Q5E9B5	Actin, gamma-enteric smooth muscle	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00012	Cadherin signaling pathway	P00470	F-actin	TRIAD|EnsemblGenome=TriadG56111|UniProtKB=B3RX77	Non-muscle actin 6.2	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00006	Apoptosis signaling pathway	P00260	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	HUMAN|HGNC=7571|UniProtKB=Q9UKX3	Myosin-13	IEP	10938134	PubMed	PTHR13140:SF504	MYOSIN-13
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000003364|UniProtKB=F6ZPQ4	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00048	PI3 kinase pathway	P01188	Gbetagamma	CAEEL|WormBase=WBGene00001680|UniProtKB=Q20636	Guanine nucleotide-binding protein subunit beta-2	IGI	11313908	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00048	PI3 kinase pathway	P01188	Gbetagamma	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	BOVIN|Ensembl=ENSBTAG00000037616|UniProtKB=F1MUD1	Uncharacterized protein	ISS			PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00036	Interleukin signaling pathway	P00970	Interleukin	MACMU|Ensembl=ENSMMUG00000023569|UniProtKB=P51496	Interleukin-10	IC			PTHR44875:SF1	INTERLEUKIN-10
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	TAS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00045	Notch signaling pathway	P01103	Next	ORNAN|Ensembl=ENSOANG00000008425|UniProtKB=F6VUQ4	Delta-like protein	ISS	12826675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	7937853	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00005	Angiogenesis	P00251	cPLA2	BOVIN|Ensembl=ENSBTAG00000013298|UniProtKB=A4IFJ5	Cytosolic phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00023	General transcription regulation	P00666	TFIIE	MACMU|Ensembl=ENSMMUG00000001596|UniProtKB=F7GV34	General transcription factor IIE subunit 1	ISS	92065982	PubMed	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00870	IL2	MOUSE|MGI=MGI=103014|UniProtKB=P48346	Interleukin-15	IDA			PTHR45114:SF1	INTERLEUKIN-15
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	MOUSE|MGI=MGI=109482|UniProtKB=P97445	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	14624853	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P05916	Opioid prodynorphin pathway	P05999	provasopressin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00010	B cell activation	P00367	NFAT	MOUSE|MGI=MGI=103296|UniProtKB=P97305	Nuclear factor of activated T-cells, cytoplasmic 3	IDA	9462517	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00006	Apoptosis signaling pathway	P00307	ELF2alpha	HUMAN|HGNC=3265|UniProtKB=P05198	Eukaryotic translation initiation factor 2 subunit 1	ISS			PTHR10602:SF0	EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	IDA	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00005	Angiogenesis	P00195	APC	HUMAN|HGNC=583|UniProtKB=P25054	Adenomatous polyposis coli protein	IDA	8259518	PubMed	PTHR12607:SF11	ADENOMATOUS POLYPOSIS COLI PROTEIN
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Gene=PCDHB11|UniProtKB=Q5DRD8	Protocadherin beta-11	ISS	8120095	PubMed	PTHR24028:SF91	PROTOCADHERIN BETA-11
P00036	Interleukin signaling pathway	P00970	Interleukin	RAT|RGD=2904|UniProtKB=P56478	Interleukin-7	IC			PTHR45542:SF1	INTERLEUKIN-7
P00006	Apoptosis signaling pathway	P00269	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00645	Rac	ENTHI|EnsemblGenome=EHI_197840|UniProtKB=C4M8K6	Rho family GTPase	ISS	8649368	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	CHICK|Ensembl=ENSGALG00000008512|UniProtKB=F1P0S6	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00034	Integrin signalling pathway	P00951	Jnk	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	15528206	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04392	P53 pathway feedback loops 1	P04536	Mdm2	MACMU|Ensembl=ENSMMUG00000011236|UniProtKB=F6WXF0	Uncharacterized protein	ISS			PTHR13844:SF20	PROTEIN MDM4
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01320	PLC-gamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00020	FAS signaling pathway	P00615	JNK	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	RCA	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00006	Apoptosis signaling pathway	P00260	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04398	p53 pathway feedback loops 2	P04651	Ras	DANRE|ZFIN=ZDB-GENE-990415-166|UniProtKB=P79737	GTPase NRas	IDA	9116869	PubMed	PTHR24070:SF189	GTPASE NRAS
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	RAT|RGD=628852|UniProtKB=Q02294	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	14507926	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P06664	Gonadotropin-releasing hormone receptor pathway	P06743	Cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	RCA	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04393	Ras Pathway	P04546	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	7667318	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	DROME|FlyBase=FBgn0010399|UniProtKB=Q24418	Glutamate [NMDA] receptor subunit 1	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00048	PI3 kinase pathway	P01199	Galpha	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00036	Interleukin signaling pathway	P00973	PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00587	Raf-1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IGI	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	HUMAN|HGNC=9508|UniProtKB=P49768	Presenilin-1	TAS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00006	Apoptosis signaling pathway	P00269	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CAEBR|Gene=CBG01555|UniProtKB=A8WRD7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	IDA	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000005792|UniProtKB=F6VTR8	Uncharacterized protein	ISS	12507995	PubMed	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00006	Apoptosis signaling pathway	P00274	JNK	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000005727|UniProtKB=F6TQT6	Uncharacterized protein	ISS	11554554	PubMed	PTHR24356:SF246	SERINE/THREONINE-PROTEIN KINASE N1
P00048	PI3 kinase pathway	P01185	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00018	EGF receptor signaling pathway	P00559	MEK1-2	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00047	PDGF signaling pathway	P01160	IP3 receptor	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00036	Interleukin signaling pathway	P00966	mTOR	MACMU|Ensembl=ENSMMUG00000019325|UniProtKB=F6RVV5	Uncharacterized protein	ISS	14526383	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00011	Blood coagulation	P00421	alpha1-antitrypsin	MACMU|Ensembl=ENSMMUG00000020426|UniProtKB=F6SEN6	Alpha-1-antitrypsin	ISS	112888	gi	PTHR11461:SF165	ALPHA-1-ANTITRYPSIN-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01012	PICK	MACMU|Ensembl=ENSMMUG00000002697|UniProtKB=F7HN39	PRKCA-binding protein	ISS	12941441	PubMed	PTHR12141:SF1	PRKCA-BINDING PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CAEBR|Gene=CBG02167|UniProtKB=A8WS37	Protein CBG02167	ISS	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04393	Ras Pathway	P04542	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	BOVIN|Ensembl=ENSBTAG00000007882|UniProtKB=G3X7Z2	Uncharacterized protein	ISS	8386525	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00029	Huntington disease	P00786	ARF	MOUSE|MGI=MGI=99434|UniProtKB=P84084	ADP-ribosylation factor 5	ISS	12932731	PubMed	PTHR11711:SF308	ADP-RIBOSYLATION FACTOR 5
P02728	Arginine biosynthesis	P02841	argininosuccinate lyase	SULSO|EnsemblGenome=SSO0639|UniProtKB=Q9UX32	Argininosuccinate lyase	ISS			PTHR43814:SF1	ARGININOSUCCINATE LYASE
P02762	Pentose phosphate pathway	P03082	Transketolase	MACMU|Ensembl=ENSMMUG00000014433|UniProtKB=F7BHR1	Transketolase	RCA			PTHR43195:SF3	TRANSKETOLASE
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04398	p53 pathway feedback loops 2	P04657	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00013	Cell cycle	P00480	Proteasome	CHICK|Ensembl=ENSGALG00000002937|UniProtKB=Q5F3J5	Proteasome activator complex subunit 3	ISS	9218537	PubMed	PTHR10660:SF4	PROTEASOME ACTIVATOR COMPLEX SUBUNIT 3
P00059	p53 pathway	P01486	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	TAS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P06664	Gonadotropin-releasing hormone receptor pathway	G06682	Isl-1	MOUSE|MGI=MGI=101791|UniProtKB=P61372	Insulin gene enhancer protein ISL-1	RCA			PTHR24204:SF3	INSULIN GENE ENHANCER PROTEIN ISL-1
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	CAEEL|WormBase=WBGene00002173|UniProtKB=Q9Y0A1	Inositol 1,4,5-trisphosphate receptor itr-1	ISS	4262086	gi	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00865	Shc	MOUSE|MGI=MGI=98296|UniProtKB=P98083	SHC-transforming protein 1	ISS	8264585	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	BOVIN|Ensembl=ENSBTAG00000011429|UniProtKB=Q8SQ19	Cyclic AMP-responsive element-binding protein 3	ISS	608972	OMIM	PTHR22952:SF100	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3
P06664	Gonadotropin-releasing hormone receptor pathway	P06794	MAP2K1/2	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	RCA	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04393	Ras Pathway	P04557	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	90172230	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01161	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IGI	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	IGI	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CAEEL|EnsemblGenome=WBGene00000051|UniProtKB=G5EDF1	AcetylCholine Receptor	IC			PTHR18945:SF495	ACETYLCHOLINE RECEPTOR
P00019	Endothelin signaling pathway	P00586	Gq	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02738	De novo purine biosynthesis	P02911	N5-carboxyaminoimidazole ribonucleotide mutase	AQUAE|EnsemblGenome=aq_1178|UniProtKB=O67239	N5-carboxyaminoimidazole ribonucleotide mutase	ISS			PTHR23046:SF2	N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE MUTASE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	PANTR|Ensembl=ENSPTRG00000019407|UniProtKB=H2QUY0	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	HUMAN|HGNC=4042|UniProtKB=Q9ULV1	Frizzled-4	TAS	8717036	PubMed	PTHR11309:SF23	FRIZZLED-4
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00029	Huntington disease	P00811	Arp2/3 complex	YEAST|SGD=S000000438|UniProtKB=P38328	Actin-related protein 2/3 complex subunit 1	TAS	12963527	gi	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P00034	Integrin signalling pathway	P00924	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01192	p110	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01451	Galpha	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Ensembl=ENSGALG00000013781|UniProtKB=F1P1D5	Uncharacterized protein	IEP	10938134	PubMed	PTHR13140:SF344	MYOSIN-7
P02738	De novo purine biosynthesis	P02898	Phosphoribosylformylglycinamide  synthase	SULSO|EnsemblGenome=SSO0629|UniProtKB=Q9UX24	Phosphoribosylformylglycinamidine synthase subunit PurL	ISS			PTHR43555:SF1	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	CAEBR|Gene=CBG02401|UniProtKB=A8WUE7	Protein CBR-NMR-1	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00006	Apoptosis signaling pathway	P00260	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	BOVIN|Ensembl=ENSBTAG00000018245|UniProtKB=P46411	Excitatory amino acid transporter 1	ISS	94365697	PubMed	PTHR11958:SF24	EXCITATORY AMINO ACID TRANSPORTER 1
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P02761	Pantothenate biosynthesis	P03069	2-Dehydropantoate reductase	STRCO|Gene=CAA22366|UniProtKB=Q9ZBV6	Putative oxidoreductase	ISS			PTHR21708:SF35	SUBFAMILY NOT NAMED
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01428	Frizzled	MACMU|Ensembl=ENSMMUG00000007486|UniProtKB=F6QL95	Frizzled-3	ISS	12549854	PubMed	PTHR11309:SF22	FRIZZLED-3
P02778	Sulfate assimilation	P03167	Sulfate adenylyltransferase	RAT|RGD=1307012|UniProtKB=A0A0G2K950	Protein Papss2	ISS			PTHR11055:SF16	BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE 2
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IGI	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	HUMAN|HGNC=30829|UniProtKB=Q9BVA1	Tubulin beta-2B chain	ISS	12932731	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00005	Angiogenesis	P00238	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P02749	Leucine biosynthesis	P03001	3-Isopropylmalate dehydrogenase	METJA|EnsemblGenome=MJ_0720|UniProtKB=Q58130	3-isopropylmalate/3-methylmalate dehydrogenase	ISS			PTHR11835:SF48	HOMOISOCITRATE DEHYDROGENASE, MITOCHONDRIAL
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	PYRAE|EnsemblGenome=PAE2251|UniProtKB=Q8ZVJ5	Aspartate aminotransferase (AspC), conjectural	ISS			PTHR11751:SF306	SUBFAMILY NOT NAMED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00005	Angiogenesis	P00193	SOS-1	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00034	Integrin signalling pathway	P00925	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	11251832	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00056	VEGF signaling pathway	P01413	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04542	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00381	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00779	TBP	PYRAE|EnsemblGenome=PAE2164|UniProtKB=Q8ZVR0	TATA-box-binding protein	IPI	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P04392	P53 pathway feedback loops 1	P04539	p53	MACMU|Ensembl=ENSMMUG00000008639|UniProtKB=P56424	Cellular tumor antigen p53	TAS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IC	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ORYSJ|EnsemblGenome=OS03G0836000|UniProtKB=Q10AZ4	Actin-3	IC	14684598	PubMed	PTHR11937:SF254	ACTIN-1-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00019	Endothelin signaling pathway	P00583	cPLA2	MACMU|Ensembl=ENSMMUG00000021423|UniProtKB=F7EEZ1	Phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	XENTR|Xenbase=XB-GENE-491571|UniProtKB=F6WW07	Uncharacterized protein (Fragment)	ISS	17943202	gi	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00053	T cell activation	P01307	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00887	IRS 1-4	RAT|RGD=2922|UniProtKB=P35570	Insulin receptor substrate 1	ISS	5031805	gi	PTHR10614:SF11	INSULIN RECEPTOR SUBSTRATE 1
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00052	TGF-beta signaling pathway	P01275	P38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00047	PDGF signaling pathway	P01157	MAPKAPK2	LEIMA|EnsemblGenome=LmjF.13.0440|UniProtKB=Q4QGB0	Mitogen-activated protein kinase kinase 2	ISS			PTHR22983:SF6	SERINE/THREONINE-PROTEIN KINASE 36
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001749|UniProtKB=H2Q0Q4	Uncharacterized protein	ISS	11976940	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00047	PDGF signaling pathway	P01152	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00005	Angiogenesis	P00238	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P05918	p38 MAPK pathway	P06022	eEF2K	HUMAN|HGNC=24615|UniProtKB=O00418	Eukaryotic elongation factor 2 kinase	IDA	11500363	PubMed	PTHR14187:SF56	EUKARYOTIC ELONGATION FACTOR 2 KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	SCHMA|EnsemblGenome=Smp_078040|UniProtKB=C4QIC0	Tubulin beta chain,putative	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00053	T cell activation	P01333	cdc42	DANRE|ZFIN=ZDB-GENE-030131-8783|UniProtKB=Q52WY2	Ras-like protein Cdc42a	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ORYSJ|EnsemblGenome=OS03G0285800|UniProtKB=Q10N20	Mitogen-activated protein kinase 5	ISS	11707292	PubMed	PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P06664	Gonadotropin-releasing hormone receptor pathway	P06826	MASH1	MOUSE|MGI=MGI=96919|UniProtKB=Q02067	Achaete-scute homolog 1	RCA			PTHR13935:SF66	ACHAETE-SCUTE HOMOLOG 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00702	CPB	PANTR|Ensembl=ENSPTRG00000010295|UniProtKB=H2QF07	Uncharacterized protein	ISS			PTHR22952:SF98	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 3
P00060	Ubiquitin proteasome pathway	P01491	E2	DAPPU|EnsemblGenome=DAPPUDRAFT_299959|UniProtKB=E9FRE8	Putative uncharacterized protein	ISS			PTHR43898:SF1	UBIQUITIN-CONJUGATING ENZYME E2-17 KDA
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MOUSE|MGI=MGI=1933206|UniProtKB=A2AIR5	Protein Grin3a	ISS	11554549	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00021	FGF signaling pathway	P00627	ERK1-2	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00056	VEGF signaling pathway	P01408	Akt/PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00470	F-actin	ANOGA|EnsemblGenome=AGAP000651|UniProtKB=P84185	Actin-5C	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	BOVIN|Ensembl=ENSBTAG00000013885|UniProtKB=A7MBG0	Adenylosuccinate synthetase isozyme 2	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS			PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02752	Mannose metabolism	P03015	GDP-Mannose 4,6-dehydratase	ARATH|TAIR=AT3G51160|UniProtKB=P93031	GDP-mannose 4,6 dehydratase 2	TAS	15239334	gi	PTHR43715:SF1	GDP-MANNOSE 4,6 DEHYDRATASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	DANRE|ZFIN=ZDB-GENE-980526-249|UniProtKB=Q9I9I2	Protein Wnt	TAS	11266476	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	BOVIN|Gene=STAT3|UniProtKB=P61635	Signal transducer and activator of transcription 3	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01080	AChE	ANOGA|EnsemblGenome=AGAP000466|UniProtKB=Q7QFG0	Carboxylic ester hydrolase	IC	86008285	PubMed	PTHR43918:SF4	ACETYLCHOLINESTERASE
P00053	T cell activation	P01332	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=1750|UniProtKB=P55287	Cadherin-11	IDA	8120095	PubMed	PTHR24027:SF85	CADHERIN-11
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00054	Toll receptor signaling pathway	P01358	ERK1	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00008	Axon guidance mediated by Slit/Robo	P00342	Slit	HUMAN|HGNC=11086|UniProtKB=O94813	Slit homolog 2 protein	ISS	10432110	PubMed	PTHR24373:SF107	SLIT HOMOLOG 2 PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DROME|FlyBase=FBgn0000045|UniProtKB=P02574	Actin, larval muscle	ISS	14684598	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	3045562	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DICDI|dictyBase=DDB_G0279413|UniProtKB=P05987	cAMP-dependent protein kinase regulatory subunit	IC	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00573	signal peptidase	BOVIN|Ensembl=ENSBTAG00000011239|UniProtKB=P67810	Signal peptidase complex catalytic subunit SEC11A	ISS	2092035	PubMed	PTHR10806:SF8	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11A-RELATED
P00005	Angiogenesis	P00227	PLA2	ORNAN|Ensembl=ENSOANG00000001027|UniProtKB=F6QDY0	Phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00046	Oxidative stress response	P01135	p38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	TAS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04393	Ras Pathway	P04559	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00637	MKK4,7	MOUSE|MGI=MGI=1346869|UniProtKB=P47809	Dual specificity mitogen-activated protein kinase kinase 4	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00864	MEK	CHICK|Ensembl=ENSGALG00000015596|UniProtKB=E1C063	Uncharacterized protein	ISS			PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P04393	Ras Pathway	P04556	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DICDI|dictyBase=DDB_G0289487|UniProtKB=P07829	Actin-3	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	DANRE|ZFIN=ZDB-GENE-051202-1|UniProtKB=E7F101	Uncharacterized protein	ISS	11319238	PubMed	PTHR44391:SF2	SUBFAMILY NOT NAMED
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00048	PI3 kinase pathway	P01206	14-3-3	HUMAN|HGNC=12855|UniProtKB=P63104	14-3-3 protein zeta/delta	ISS	92283271	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MOUSE|MGI=MGI=1346875|UniProtKB=O08648	Mitogen-activated protein kinase kinase kinase 4	IGI	10207617	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05913	Enkephalin release	P05977	G-Protein (s)	DROME|FlyBase=FBgn0001123|UniProtKB=P20354	G protein alpha s subunit	IC	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CANAL|CGD=CAL0064759|UniProtKB=Q5AKX0	Uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05918	p38 MAPK pathway	P05922	MKP1	HUMAN|HGNC=3064|UniProtKB=P28562	Dual specificity protein phosphatase 1	RCA			PTHR10159:SF309	DUAL SPECIFICITY PROTEIN PHOSPHATASE 1
P00034	Integrin signalling pathway	P00927	Rac	BRAFL|Gene=BRAFLDRAFT_126918|UniProtKB=C3YJC1	Putative uncharacterized protein	ISS	21244534	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00019	Endothelin signaling pathway	P00589	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01185	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00048	PI3 kinase pathway	P01200	SHIP	MACMU|Ensembl=ENSMMUG00000010451|UniProtKB=F7CRA7	Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2	ISS	10381377	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P06216	SCW signaling pathway	P06326	SCW	DROME|FlyBase=FBgn0005590|UniProtKB=P54631	Protein screw	IEA	7958918	PubMed	PTHR11848:SF54	PROTEIN 60A-RELATED
P00052	TGF-beta signaling pathway	P01276	Co-Smads	DANRE|ZFIN=ZDB-GENE-110408-38|UniProtKB=E7FGT9	Mothers against decapentaplegic homolog	ISS			PTHR13703:SF34	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG
P00047	PDGF signaling pathway	P01162	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IDA	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00053	T cell activation	P01319	PAK	PANTR|Ensembl=ENSPTRG00000015787|UniProtKB=H2QP14	Uncharacterized protein	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00018	EGF receptor signaling pathway	P00540	MKK3,6	CANLF|Ensembl=ENSCAFG00000018530|UniProtKB=F1PXD3	Uncharacterized protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00778	NMDA receptor	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00019	Endothelin signaling pathway	P00591	PLCbeta	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04494	TSC2	RAT|RGD=3908|UniProtKB=P49816	Tuberin	IDA	15249583	PubMed	PTHR10063:SF0	TUBERIN
P00018	EGF receptor signaling pathway	P00547	PP2A	BOVIN|Ensembl=ENSBTAG00000009245|UniProtKB=Q0P594	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00054	Toll receptor signaling pathway	P01345	IKKalpha	BOVIN|Ensembl=ENSBTAG00000007591|UniProtKB=Q95KV1	Inhibitor of nuclear factor kappa-B kinase subunit alpha	ISS	12813046	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00025	Hedgehog signaling pathway	P00692	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05913	Enkephalin release	P05972	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P02723	Adenine and hypoxanthine salvage pathway	P02813	Inosine phosphorylase	BACSU|EnsemblGenome=BSU23490|UniProtKB=P46354	Purine nucleoside phosphorylase 1	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	BOVIN|Gene=CACNB1|UniProtKB=Q9MZL7	Voltage-dependent L-type calcium channel subunit beta-1	IC	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00046	Oxidative stress response	P01135	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	TAS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00036	Interleukin signaling pathway	P00977	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	BOVIN|Ensembl=ENSBTAG00000013555|UniProtKB=F1MSQ2	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P05913	Enkephalin release	P05971	CREB	PANTR|Ensembl=ENSPTRG00000023623|UniProtKB=H2R2Y2	Uncharacterized protein	ISS	11752053	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	HALSA|EnsemblGenome=VNG_0896G|UniProtKB=Q9HR24	Cytidine aminohydrolase	ISS			PTHR11644:SF2	CYTIDINE DEAMINASE
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	RAT|RGD=727861|UniProtKB=Q5BKE0	Transcription initiation factor TFIID subunit 9	ISS			PTHR12595:SF8	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 9
P00056	VEGF signaling pathway	P01414	PLC-gamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	RCA	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00029	Huntington disease	P00805	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01457	GBeta	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04397	p53 pathway by glucose deprivation	P04641	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01431	LRP5/6	MACMU|Ensembl=ENSMMUG00000023317|UniProtKB=F6Y514	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	TAS	11007936	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P04398	p53 pathway feedback loops 2	P04657	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05918	p38 MAPK pathway	P06032	MKK6	RAT|RGD=620666|UniProtKB=Q925D6	Mitogen-activated protein kinase kinase 6	ISS	8622669	PubMed	PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P00029	Huntington disease	P00790	beta-Tubulin	RAT|RGD=628595|UniProtKB=Q4QRB4	Tubulin beta-3 chain	TAS	9454836	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000001384|UniProtKB=F7GL73	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00024	Glycolysis	P00679	Aldolase	MOUSE|MGI=MGI=87994|UniProtKB=P05064	Fructose-bisphosphate aldolase A	ISS	6086339	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P04393	Ras Pathway	P04572	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00029	Huntington disease	P00807	Actin	TRIAD|EnsemblGenome=TriadG35956|UniProtKB=Q7YTV5	Actin	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00052	TGF-beta signaling pathway	P01292	RSmads	DROME|FlyBase=FBgn0011648|UniProtKB=P42003	Protein mothers against dpp	TAS	9395284	PubMed	PTHR13703:SF40	PROTEIN MOTHERS AGAINST DPP
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	4506785	gi	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	CHICK|Ensembl=ENSGALG00000000681|UniProtKB=E1C3P6	Uncharacterized protein	ISS	14580336	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	PANTR|Ensembl=ENSPTRG00000005063|UniProtKB=H2Q663	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF166	GROWTH/DIFFERENTIATION FACTOR 11
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	DROME|FlyBase=FBgn0263116|UniProtKB=P28286	5-hydroxytryptamine receptor 2B	ISS	8143856	PubMed	PTHR24247:SF117	5-HYDROXYTRYPTAMINE RECEPTOR 2A-RELATED
P00010	B cell activation	P00375	Calmodulin	CHICK|Gene_ORFName=RCJMB04_24e7|UniProtKB=P62149	Calmodulin	ISS	7514101	PubMed	PTHR23050:SF311	CALMODULIN
P00006	Apoptosis signaling pathway	P00272	ASK1	MOUSE|MGI=MGI=1346876|UniProtKB=O35099	Mitogen-activated protein kinase kinase kinase 5	ISS	12566458	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=109485|UniProtKB=Q9WUD6	Protein Wnt-8b	IDA	8717036	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ORYSJ|EnsemblGenome=OS05G0106600|UniProtKB=Q65XH8	Os05g0106600 protein	IC	14684598	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00056	VEGF signaling pathway	P01417	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IGI	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00053	T cell activation	P01336	Jnk	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00005	Angiogenesis	P00227	PLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	IDA	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00054	Toll receptor signaling pathway	P01366	MKK4	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CANLF|Ensembl=ENSCAFG00000017522|UniProtKB=Q076A4	Myosin-8	ISS	89264452	PubMed	PTHR13140:SF368	MYOSIN-8
P04397	p53 pathway by glucose deprivation	P04639	AMPK	BOVIN|Gene=PRKAG1|UniProtKB=P58108	5'-AMP-activated protein kinase subunit gamma-1	ISS			PTHR13780:SF38	5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	ANOGA|EnsemblGenome=AGAP005911|UniProtKB=Q7Q6D4	AGAP005911-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00010	B cell activation	P00381	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CHICK|Ensembl=ENSGALG00000009405|UniProtKB=F1NKF1	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P02788	Xanthine and guanine salvage pathway	P03247	Xanthine phosphoribosyl transferase	MACMU|Ensembl=ENSMMUG00000018728|UniProtKB=F6YAZ3	Uncharacterized protein	ISS			PTHR43340:SF5	PHOSPHORIBOSYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1
P00034	Integrin signalling pathway	P00922	Collagen	RAT|RGD=1305585|UniProtKB=F1LNH3	Procollagen, type VI, alpha 2, isoform CRA_a	ISS	10778855	PubMed	PTHR44172:SF1	COLLAGEN ALPHA-2 VI  CHAIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04558	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00648	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	87226391	PubMed	PTHR24070:SF385	GTPASE HRAS
P05734	Synaptic vesicle trafficking	P05770	Munc18	RAT|RGD=3785|UniProtKB=P61765	Syntaxin-binding protein 1	ISS	8108429	PubMed	PTHR11679:SF35	SYNTAXIN-BINDING PROTEIN 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	BRAFL|Gene=BRAFLDRAFT_128184|UniProtKB=C4A0B6	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	HUMAN|HGNC=4572|UniProtKB=P42262	Glutamate receptor 2	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00029	Huntington disease	P00786	ARF	ORYSJ|EnsemblGenome=OS10G0580200|UniProtKB=Q336M3	ADP-ribosylation factor, putative, expressed	IPI	12932731	PubMed	PTHR11711:SF300	ADP-RIBOSYLATION FACTOR B1C
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00046	Oxidative stress response	P01129	JNK1/2	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	IC	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	IDA	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05934	ELK1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	RCA	10487205	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00053	T cell activation	P01336	Jnk	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT1G59580|UniProtKB=Q39022	Mitogen-activated protein kinase 2	ISS	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	HUMAN|HGNC=4583|UniProtKB=Q16478	Glutamate receptor ionotropic, kainate 5	ISS	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00057	Wnt signaling pathway	P01465	Ggamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00047	PDGF signaling pathway	P01160	IP3 receptor	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DICPU|Gene=DICPUDRAFT_46519|UniProtKB=F0Z796	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	PANTR|Ensembl=ENSPTRG00000016891|UniProtKB=H2R5K3	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00036	Interleukin signaling pathway	P00973	PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=12780|UniProtKB=P09544	Protein Wnt-2	IDA	8717036	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01428	Frizzled	DANRE|ZFIN=ZDB-GENE-000906-4|UniProtKB=B0S5E7	Frizzled homolog 9	IDA	8717036	PubMed	PTHR11309:SF79	FRIZZLED-9
P00057	Wnt signaling pathway	P01455	Smad4	MOUSE|MGI=MGI=109452|UniProtKB=P70340	Mothers against decapentaplegic homolog 1	IDA	9395284	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P00025	Hedgehog signaling pathway	P00682	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00011	Blood coagulation	P00447	FVIIa	MOUSE|MGI=MGI=109325|UniProtKB=P70375	Coagulation factor VII	ISS	2499859	gi	PTHR44064:SF1	COAGULATION FACTOR VII
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04547	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00041	Metabotropic glutamate receptor group I pathway	P01062	mGluR1	HUMAN|HGNC=4593|UniProtKB=Q13255	Metabotropic glutamate receptor 1	ISS	12351712	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01147	Nck	MOUSE|MGI=MGI=109601|UniProtKB=Q99M51	Cytoplasmic protein NCK1	ISS	11689432	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P00020	FAS signaling pathway	P00600	PARP	RAT|RGD=2053|UniProtKB=P27008	Poly [ADP-ribose] polymerase 1	TAS	12101391	PubMed	PTHR10459:SF80	POLY  ADP-RIBOSE  POLYMERASE 1
P04393	Ras Pathway	P04542	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00223	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00023	General transcription regulation	P00670	TBP	MONDO|Ensembl=ENSMODG00000017515|UniProtKB=F7F0J5	Uncharacterized protein	ISS	600075	OMIM	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P04393	Ras Pathway	P04557	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	ARATH|TAIR=AT2G43750|UniProtKB=P47999	Cysteine synthase, chloroplastic/chromoplastic	ISS			PTHR10314:SF131	CYSTEINE SYNTHASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00470	F-actin	RAT|RGD=1309504|UniProtKB=D3ZRN3	Protein Actbl2	ISS	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P05731	GABA-B receptor II signaling	P05752	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02772	Pyruvate metabolism	P03137	Citrate Lyase	CAEBR|Gene=CBG11570|UniProtKB=A8XDI6	Protein CBG11570	ISS			PTHR32308:SF0	CITRATE LYASE SUBUNIT BETA
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04392	P53 pathway feedback loops 1	G04684	Pirh-2	MACMU|Ensembl=ENSMMUG00000009177|UniProtKB=F7HPB9	RING finger and CHY zinc finger domain-containing protein 1	ISS	607680	OMIM	PTHR21319:SF20	RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PHYIT|EnsemblGenome=PITG_15117|UniProtKB=D0NRP9	Actin-like protein	IDA			PTHR11937:SF155	ACTIN-5C-RELATED
P00059	p53 pathway	G04693	WIP-1	MACMU|Ensembl=ENSMMUG00000018049|UniProtKB=F7HUA9	Uncharacterized protein	ISS			PTHR13832:SF359	PROTEIN PHOSPHATASE 1D
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02738	De novo purine biosynthesis	P02905	Amidophosphoribosyl transferase	PYRAE|EnsemblGenome=PAE0226|UniProtKB=Q8ZZJ6	Amidophosphoribosyltransferase	ISS			PTHR11907:SF0	AMIDOPHOSPHORIBOSYLTRANSFERASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	TAKRU|Ensembl=ENSTRUG00000003225|UniProtKB=H2S581	Uncharacterized protein	IDA	11781138	PubMed	PTHR24248:SF0	ALPHA-2DA ADRENERGIC RECEPTOR-RELATED
P05731	GABA-B receptor II signaling	P05758	K channel	XENTR|Xenbase=XB-GENE-1004371|UniProtKB=F6R882	Uncharacterized protein	ISS	2433589	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00006	Apoptosis signaling pathway	P00269	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00928	alpha actinin	BOVIN|Ensembl=ENSBTAG00000011215|UniProtKB=A5D7D1	Alpha-actinin-4	ISS	2116421	PubMed	PTHR43947:SF7	ALPHA-ACTININ-4
P02753	Methionine biosynthesis	P03024	Homocysteine transmethylase	RAT|RGD=621283|UniProtKB=Q9Z2Q4	Methionine synthase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P02766	Phenylethylamine degradation	P03103	Phenylethylamine oxidase	ECOLI|EcoGene=EG13140|UniProtKB=P46883	Primary amine oxidase	ISS			PTHR10638:SF41	AMINE OXIDASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	MACMU|Ensembl=ENSMMUG00000011442|UniProtKB=F7B9T3	Ras-related protein Rap-1b	ISS	1904317	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01174	Rho	RAT|RGD=1588859|UniProtKB=D4AB50	Protein Arhgap10	ISS	8649427	PubMed	PTHR12552:SF5	RHO GTPASE-ACTIVATING PROTEIN 10
P00006	Apoptosis signaling pathway	P00274	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	ISS	12040174	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00025	Hedgehog signaling pathway	P00692	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02730	Asparagine and aspartate biosynthesis	P02853	Asparagine synthetase	CAEBR|Gene=CBG15441|UniProtKB=A8XMA3	Protein CBR-ASNS-2	ISS			PTHR11772:SF2	ASPARAGINE SYNTHETASE
P00010	B cell activation	P00379	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00034	Integrin signalling pathway	P00931	Integrin beta	RAT|RGD=2928|UniProtKB=Q64632	Integrin beta-4	IDA	3487386	PubMed	PTHR10082:SF42	INTEGRIN BETA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	XENTR|Xenbase=XB-GENE-944026|UniProtKB=F6VZM7	Adenosine receptor A1 (Fragment)	ISS	11781138	PubMed	PTHR24246:SF1	ADENOSINE RECEPTOR A1
P04393	Ras Pathway	P04558	p38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IDA	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00034	Integrin signalling pathway	P00951	Jnk	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	IDA	11007936	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02747	Histidine biosynthesis	P02992	Imidazol glycerol phosphate synthase	GLOVI|EnsemblGenome=BAC92255|UniProtKB=Q7NDC1	Imidazole glycerol phosphate synthase subunit HisF	ISS			PTHR21235:SF2	IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF
P00034	Integrin signalling pathway	P00920	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	BOVIN|Gene=DRD2|UniProtKB=P20288	D(2) dopamine receptor	ISS	11861492	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00018	EGF receptor signaling pathway	P00564	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00034	Integrin signalling pathway	P00907	ERK	HUMAN|HGNC=6879|UniProtKB=Q16659	Mitogen-activated protein kinase 6	ISS	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00019	Endothelin signaling pathway	P00572	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00705	Gsalpha	MOUSE|MGI=MGI=95774|UniProtKB=Q8CGK7	Guanine nucleotide-binding protein G(olf) subunit alpha	ISS	14765990	PubMed	PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	RAT|RGD=2344|UniProtKB=P08485	Muscarinic acetylcholine receptor M4	TAS	11166329	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00018	EGF receptor signaling pathway	P00550	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8479536	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00054	Toll receptor signaling pathway	P01345	IKKalpha	MOUSE|MGI=MGI=99484|UniProtKB=Q60680	Inhibitor of nuclear factor kappa-B kinase subunit alpha	ISS	9346484	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	XENTR|Xenbase=XB-GENE-977853|UniProtKB=F7EBE7	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	HUMAN|HGNC=4587|UniProtKB=Q14957	Glutamate receptor ionotropic, NMDA 2C	IC	11554549	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00059	p53 pathway	G04694	p110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00009	Axon guidance mediated by netrin	P00357	Netrin	MACMU|Ensembl=ENSMMUG00000009397|UniProtKB=F7HEU6	Uncharacterized protein	ISS	9427245	PubMed	PTHR10574:SF365	NETRIN-1
P00011	Blood coagulation	P00418	Fibrin monomer	HUMAN|HGNC=3662|UniProtKB=P02675	Fibrinogen beta chain	ISS	11761631	gi	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00041	Metabotropic glutamate receptor group I pathway	P01062	mGluR1	MACMU|Ensembl=ENSMMUG00000016428|UniProtKB=F7GU00	Metabotropic glutamate receptor 1 isoform alpha	ISS	12351712	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P02787	Vitamin B6 metabolism	P03236	Pyridoxamine phosphate oxidase	MOUSE|MGI=MGI=2144151|UniProtKB=Q91XF0	Pyridoxine-5'-phosphate oxidase	ISS	14697241	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MACMU|Ensembl=ENSMMUG00000014754|UniProtKB=F7G124	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF721	MYOSIN-6
P02757	O-antigen biosynthesis	P03047	dTDP-4-dehydrorhamnose 3,5-epimerase	BACTN|EnsemblGenome=BT_0828|UniProtKB=Q8A9I7	dTDP-4-dehydrorhamnose 3,5-epimerase	ISS			PTHR21047:SF2	DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE
P00047	PDGF signaling pathway	P01160	IP3 receptor	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CAEEL|WormBase=WBGene00004036|UniProtKB=G5EFI8	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	IC	10477300	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00005	Angiogenesis	P00243	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04665	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01242	Casein kinase I	RAT|RGD=71031|UniProtKB=Q06486	Casein kinase I isoform delta	IDA	10617630	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P05913	Enkephalin release	P05974	G-Protein (i)	ANOGA|EnsemblGenome=AGAP005773|UniProtKB=A0NEH6	AGAP005773-PA	IC	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05941	GRK3	MOUSE|MGI=MGI=87941|UniProtKB=Q3UYH7	Beta-adrenergic receptor kinase 2	ISS	10852916	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MONDO|Ensembl=ENSMODG00000011829|UniProtKB=F7GLU7	Uncharacterized protein	ISS			PTHR13140:SF277	UNCONVENTIONAL MYOSIN-IB
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014262|UniProtKB=F7BYS8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00010	B cell activation	P00385	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12874273	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00021	FGF signaling pathway	P00633	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00034	Integrin signalling pathway	P00951	Jnk	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=98327|UniProtKB=P30873	Somatostatin receptor type 1	IDA	12181435	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P00052	TGF-beta signaling pathway	P01292	RSmads	MOUSE|MGI=MGI=1328787|UniProtKB=P97454	Mothers against decapentaplegic homolog 5	TAS	12736218	PubMed	PTHR13703:SF36	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	BOVIN|Ensembl=ENSBTAG00000015848|UniProtKB=G3X778	Uncharacterized protein	ISS	10487978	PubMed	PTHR10749:SF4	PHOSPHORYLASE B KINASE REGULATORY SUBUNIT ALPHA, SKELETAL MUSCLE ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P06959	CCKR signaling map	G07265	CXCL2	HUMAN|HGNC=4603|UniProtKB=P19875	C-X-C motif chemokine 2	RCA	20671197	PubMed	PTHR10179:SF46	C-X-C MOTIF CHEMOKINE 2
P00036	Interleukin signaling pathway	P00997	Shc	BOVIN|Ensembl=ENSBTAG00000019838|UniProtKB=Q0IIE2	SHC-transforming protein 1	ISS	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P04375	5HT3 type receptor mediated signaling pathway	P04422	5HT3 Rec	MACMU|Ensembl=ENSMMUG00000013846|UniProtKB=F6SYE8	Uncharacterized protein	ISS	7509203	PubMed	PTHR18945:SF764	5-HYDROXYTRYPTAMINE RECEPTOR 3C
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01188	Gbetagamma	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	CHICK|Gene=CHRM3|UniProtKB=P49578	Muscarinic acetylcholine receptor M3	ISS	12915051	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P02772	Pyruvate metabolism	P03140	Pyruvate Carboxylase	CAEEL|WormBase=WBGene00004258|UniProtKB=O17732	Pyruvate carboxylase 1	ISS	11761713	PubMed	PTHR43778:SF2	PYRUVATE CARBOXYLASE, MITOCHONDRIAL
P00019	Endothelin signaling pathway	P00586	Gq	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00938	Cdc42	HUMAN|HGNC=1736|UniProtKB=P60953	Cell division control protein 42 homolog	IDA	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P05731	GABA-B receptor II signaling	P05752	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_114958|UniProtKB=C3XZ13	Putative uncharacterized protein	ISS			PTHR11937:SF359	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	IC	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01043	AC	MOUSE|MGI=MGI=2660854|UniProtKB=Q8C0T9	Adenylate cyclase type 10	IC	11744988	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DROME|FlyBase=FBgn0013343|UniProtKB=Q24547	Syntaxin-1A	ISS	97410052	PubMed	PTHR19957:SF41	SYNTAXIN-1A
P00005	Angiogenesis	P00237	FRP	MACMU|Ensembl=ENSMMUG00000007486|UniProtKB=F6QL95	Frizzled-3	ISS	8717036	PubMed	PTHR11309:SF22	FRIZZLED-3
P00006	Apoptosis signaling pathway	P00269	MAPK	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MOUSE|MGI=MGI=1933206|UniProtKB=A2AIR5	Protein Grin3a	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00059	p53 pathway	P01481	ATM/ATR	HUMAN|HGNC=882|UniProtKB=Q13535	Serine/threonine-protein kinase ATR	TAS	10196661	PubMed	PTHR11139:SF69	SERINE/THREONINE-PROTEIN KINASE ATR
P06209	ALP23B signaling pathway	P06218	PUT	DROME|Gene=Dmel_CG7904|UniProtKB=A0A0B4KG59	Serine/threonine-protein kinase receptor	IEA	http://flybase.org/reports/FBgn0003169.html	Website	PTHR23255:SF70	SERINE/THREONINE-PROTEIN KINASE RECEPTOR
P00005	Angiogenesis	P00243	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ARATH|TAIR=AT2G42100|UniProtKB=Q8RYC2	Putative actin-5	IDA			PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	NEUCR|EnsemblGenome=EFNCRG00000008769|UniProtKB=P22126	Protein ras-1	ISS	7997267	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00056	VEGF signaling pathway	P01413	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P01486	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_127489|UniProtKB=C3XYC6	Putative uncharacterized protein	IDA	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04398	p53 pathway feedback loops 2	P04658	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	IGI	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00212	EphR	PANTR|Ensembl=ENSPTRG00000015696|UniProtKB=H2QNV9	Uncharacterized protein	ISS	9990854	PubMed	PTHR24416:SF120	EPHRIN TYPE-B RECEPTOR 3
P00047	PDGF signaling pathway	P01168	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	G04694	p110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00402	Jnk	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	CAEBR|Gene=CBG_05938|UniProtKB=H8WGV2	Protein CBR-ITR-1, isoform a	ISS	9065779	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00048	PI3 kinase pathway	P01199	Galpha	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	IC	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04557	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IDA	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00059	p53 pathway	P04609	PI3K	ARATH|TAIR=AT1G60490|UniProtKB=P42339	Phosphatidylinositol 3-kinase VPS34	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	CANLF|Ensembl=ENSCAFG00000001130|UniProtKB=E2RMC0	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P05916	Opioid prodynorphin pathway	P06001	AC	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00021	FGF signaling pathway	P00628	JNK1-3	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00016	Cytoskeletal regulation by Rho GTPase	P00519	ROCK	MACMU|Ensembl=ENSMMUG00000016678|UniProtKB=F6VT97	Rho-associated protein kinase	ISS			PTHR22988:SF28	RHO-ASSOCIATED PROTEIN KINASE 2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02723	Adenine and hypoxanthine salvage pathway	P02813	Inosine phosphorylase	BOVIN|Ensembl=ENSBTAG00000012317|UniProtKB=P55859	Purine nucleoside phosphorylase	ISS	9585525	PubMed	PTHR11904:SF12	PURINE NUCLEOSIDE PHOSPHORYLASE
P00010	B cell activation	P00402	Jnk	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	TRYB2|Gene=Tb10.6k15.2790|UniProtKB=Q38AI6	Mitogen-activated protein kinase	ISS			PTHR24055:SF178	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000024992|UniProtKB=F6TUR3	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	RAT|RGD=3251|UniProtKB=Q62829	Serine/threonine-protein kinase PAK 3	ISS	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00226	Delta/Serrate	PANTR|Ensembl=ENSPTRG00000013250|UniProtKB=H2QJZ0	Delta-like protein	ISS	12826675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Gene=OPRM1|UniProtKB=Q5IS39	Mu-type opioid receptor	ISS	12093103	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00018	EGF receptor signaling pathway	P00545	JNK1-3	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00046	Oxidative stress response	P01125	Stat1	DANRE|ZFIN=ZDB-GENE-980526-499|UniProtKB=Q6P943	Signal transducer and activator of transcription	TAS	99348060	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	ORNAN|Ensembl=ENSOANG00000009275|UniProtKB=F7EJA3	Uncharacterized protein	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00018	EGF receptor signaling pathway	P00547	PP2A	NEUCR|EnsemblGenome=EFNCRG00000006348|UniProtKB=P48580	Serine/threonine-protein phosphatase PP2A catalytic subunit	ISS			PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00029	Huntington disease	P00780	Microtubule	MONDO|Ensembl=ENSMODG00000023805|UniProtKB=F7F082	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01161	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=1953|UniProtKB=P08173	Muscarinic acetylcholine receptor M4	IDA	12181435	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00037	Ionotropic glutamate receptor pathway	P01015	Glu4	CHICK|Ensembl=ENSGALG00000017178|UniProtKB=F1N982	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00058	mRNA splicing	P01476	U4	PANTR|Ensembl=ENSPTRG00000001254|UniProtKB=G2HGL9	PRP3 pre-mRNA processing factor 3 homolog	ISS	9328476	PubMed	PTHR14212:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3
P00006	Apoptosis signaling pathway	P00274	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CAEEL|WormBase=WBGene00004036|UniProtKB=G5EFI8	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00029	Huntington disease	P00796	Kainate receptor	MACMU|Ensembl=ENSMMUG00000004886|UniProtKB=F7AGT9	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00045	Notch signaling pathway	P01110	Presenilin	PANTR|Ensembl=ENSPTRG00000006510|UniProtKB=H2Q8K1	Presenilin	ISS	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	BOVIN|Ensembl=ENSBTAG00000004279|UniProtKB=P61585	Transforming protein RhoA	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00037	Ionotropic glutamate receptor pathway	P01015	Glu4	DANRE|ZFIN=ZDB-GENE-030131-8013|UniProtKB=F1QBT6	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00021	FGF signaling pathway	P00641	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	XENTR|Xenbase=XB-GENE-961282|UniProtKB=Q6DF43	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	ORNAN|Ensembl=ENSOANG00000006877|UniProtKB=F7CQF2	Uncharacterized protein	ISS	11029006	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	MOUSE|MGI=MGI=109482|UniProtKB=P97445	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	14507926	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00006	Apoptosis signaling pathway	P00275	Bak	HUMAN|HGNC=949|UniProtKB=Q16611	Bcl-2 homologous antagonist/killer	IDA	7715730	PubMed	PTHR11256:SF41	BCL-2 HOMOLOGOUS ANTAGONIST/KILLER
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00016	Cytoskeletal regulation by Rho GTPase	P00516	Ena/VASP	HUMAN|HGNC=18271|UniProtKB=Q8N8S7	Protein enabled homolog	RCA			PTHR11202:SF1	PROTEIN ENABLED HOMOLOG
P00021	FGF signaling pathway	P00624	14-3-3	ARATH|TAIR=AT1G22300|UniProtKB=P48347	14-3-3-like protein GF14 epsilon	ISS	10407019	PubMed	PTHR18860:SF32	14-3-3 FAMILY PROTEIN-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00034	Integrin signalling pathway	P00922	Collagen	CANLF|Ensembl=ENSCAFG00000009059|UniProtKB=F1PS24	Uncharacterized protein	IDA	10778855	PubMed	PTHR24023:SF58	COLLAGEN ALPHA-1 II  CHAIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00054	Toll receptor signaling pathway	P01381	Ubc13	PANTR|Ensembl=ENSPTRG00000005297|UniProtKB=H2Q6L8	Ubiquitin-conjugating enzyme E2N	ISS			PTHR43902:SF5	UBIQUITIN-CONJUGATING ENZYME E2 N
P00046	Oxidative stress response	P01129	JNK1/2	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00648	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00048	PI3 kinase pathway	P01199	Galpha	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS			PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04397	p53 pathway by glucose deprivation	P04640	p53	PANTR|Ensembl=ENSPTRG00000008703|UniProtKB=H2QC53	Cellular tumor antigen p53	ISS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-040426-2280|UniProtKB=Q6P025	Gnb3 protein	ISS			PTHR19850:SF35	GNB3 PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	88241036	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00029	Huntington disease	P00777	CBP	MACMU|Ensembl=ENSMMUG00000000893|UniProtKB=F6T7D0	Histone acetyltransferase p300	ISS	10664585	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00056	VEGF signaling pathway	P01407	Erk	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=98953|UniProtKB=P04426	Proto-oncogene Wnt-1	IDA	14644163	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	RAT|RGD=628852|UniProtKB=Q02294	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	14624853	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00021	FGF signaling pathway	P00643	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00391	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00572	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IGI	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00780	Microtubule	MACMU|Ensembl=ENSMMUG00000023785|UniProtKB=F7HTD6	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05916	Opioid prodynorphin pathway	P05999	provasopressin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00047	PDGF signaling pathway	P01162	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00554	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	8491186	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	PANTR|Gene=CHRM5|UniProtKB=Q5IS53	Muscarinic acetylcholine receptor M5	ISS	12181435	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	8920915	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00005	Angiogenesis	P00226	Delta/Serrate	MACMU|Ensembl=ENSMMUG00000018116|UniProtKB=F7FGM9	Delta-like protein	ISS	12826675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00034	Integrin signalling pathway	P00938	Cdc42	TAKRU|Ensembl=ENSTRUG00000008289|UniProtKB=H2T7U8	Uncharacterized protein	ISS	12928366	PubMed	PTHR24072:SF129	CDC42L PROTEIN
P00046	Oxidative stress response	P01131	MKP5	CAEEL|WormBase=WBGene00021867|UniProtKB=Q95XK5	Uncharacterized protein	ISS			PTHR10159:SF402	DUAL SPECIFICITY PROTEIN PHOSPHATASE 19
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	IDA	11007936	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	CANLF|Ensembl=ENSCAFG00000017522|UniProtKB=Q076A4	Myosin-8	ISS	89264452	PubMed	PTHR13140:SF368	MYOSIN-8
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00047	PDGF signaling pathway	P01173	STAT	MOUSE|MGI=MGI=103035|UniProtKB=P42232	Signal transducer and activator of transcription 5B	ISS	22320921	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00034	Integrin signalling pathway	P00944	Actin	BOVIN|Ensembl=ENSBTAG00000014614|UniProtKB=P62739	Actin, aortic smooth muscle	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00260	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02763	Peptidoglycan biosynthesis	P03092	Phospho-N-acetylmuramoyl pentapeptide transferase	LEPIN|EnsemblGenome=LA_2048|UniProtKB=Q8F4J3	Phospho-N-acetylmuramoyl-pentapeptide-transferase	ISS			PTHR22926:SF5	PHOSPHO-N-ACETYLMURAMOYL-PENTAPEPTIDE-TRANSFERASE
P00021	FGF signaling pathway	P00641	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04398	p53 pathway feedback loops 2	P04657	P110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00034	Integrin signalling pathway	P00924	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	MACMU|Ensembl=ENSMMUG00000000612|UniProtKB=F7CDE0	Nucleoside diphosphate kinase	ISS			PTHR11349:SF49	NUCLEOSIDE DIPHOSPHATE KINASE, MITOCHONDRIAL
P00021	FGF signaling pathway	P00627	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	11204774	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00029	Huntington disease	P00786	ARF	MOUSE|MGI=MGI=99431|UniProtKB=P84078	ADP-ribosylation factor 1	ISS	11752622	PubMed	PTHR11711:SF234	ADP-RIBOSYLATION FACTOR 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	CHICK|Ensembl=ENSGALG00000006297|UniProtKB=F1NYQ1	Uncharacterized protein	ISS	11055438	PubMed	PTHR10117:SF9	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 7
P00023	General transcription regulation	P00668	TFIIB	MONDO|Ensembl=ENSMODG00000014076|UniProtKB=F6R525	Uncharacterized protein	ISS			PTHR12458:SF8	CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	RAT|RGD=2740|UniProtKB=Q62645	Glutamate receptor ionotropic, NMDA 2D	IC	14698601	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00012	Cadherin signaling pathway	P00470	F-actin	GIAIC|EnsemblGenome=GL50803_40817|UniProtKB=A8BV70	Actin related protein	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00019	Endothelin signaling pathway	P00566	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00925	MEK	MONDO|Ensembl=ENSMODG00000008266|UniProtKB=F6Z879	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95817|UniProtKB=Q8BMF5	Glutamate receptor ionotropic, kainate 4	ISS	12778120	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00047	PDGF signaling pathway	P01153	GSK3	ORYSJ|EnsemblGenome=OS10G0521700|UniProtKB=Q8LNI5	Os10g0521700 protein	ISS	12615961	PubMed	PTHR24057:SF19	SHAGGY-RELATED PROTEIN KINASE BETA-RELATED
P00047	PDGF signaling pathway	P01159	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00010	B cell activation	P00384	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04398	p53 pathway feedback loops 2	P04661	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	ISS	12660731	PubMed	PTHR10048:SF14	PI-3 KINASE
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	HUMAN|HGNC=4584|UniProtKB=Q05586	Glutamate receptor ionotropic, NMDA 1	ISS	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00057	Wnt signaling pathway	P01452	NFAT	HUMAN|HGNC=7775|UniProtKB=O95644	Nuclear factor of activated T-cells, cytoplasmic 1	IDA	9133421	PubMed	PTHR12533:SF5	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04393	Ras Pathway	P04572	JNK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00050	Plasminogen activating cascade	P01253	Fibrin	PANTR|Ensembl=ENSPTRG00000016534|UniProtKB=H2QQB4	Uncharacterized protein	ISS	6575700	PubMed	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00019	Endothelin signaling pathway	P00567	PKG	MACMU|Ensembl=ENSMMUG00000010844|UniProtKB=F7G3L7	cGMP-dependent protein kinase	ISS	14568994	PubMed	PTHR24353:SF68	SUBFAMILY NOT NAMED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	94313981	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF31	SUBFAMILY NOT NAMED
P00003	Alzheimer disease-amyloid secretase pathway	P00084	X11alpha	HUMAN|HGNC=578|UniProtKB=Q02410	Amyloid beta A4 precursor protein-binding family A member 1	IDA	9614075	PubMed	PTHR12345:SF14	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 1
P04393	Ras Pathway	P04570	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02738	De novo purine biosynthesis	P02902	ADP reductase	MOUSE|MGI=MGI=98181|UniProtKB=P11157	Ribonucleoside-diphosphate reductase subunit M2	ISS			PTHR23409:SF20	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00019	Endothelin signaling pathway	P00568	PKC	DANRE|ZFIN=ZDB-GENE-041001-104|UniProtKB=Q5TZD4	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	ORNAN|Ensembl=ENSOANG00000007405|UniProtKB=F7CIV4	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	PANTR|Ensembl=ENSPTRG00000006342|UniProtKB=H2Q8A8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	IDA	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P00007	Axon guidance mediated by semaphorins	P00340	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12932731	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00048	PI3 kinase pathway	P01177	P110ACT	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	IC	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	XENTR|Xenbase=XB-GENE-961282|UniProtKB=Q6DF43	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04393	Ras Pathway	P04541	p90RSK	MACMU|Ensembl=ENSMMUG00000002134|UniProtKB=F6UNV6	Ribosomal protein S6 kinase	ISS	10480933	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	LEIMA|EnsemblGenome=LmjF.09.0910|UniProtKB=Q4QHT2	Putative calmodulin	ISS			PTHR23050:SF245	AT16150P-RELATED
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01227	20S proteasome	CANLF|Ensembl=ENSCAFG00000010495|UniProtKB=J9P9G4	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF12	PROTEASOME SUBUNIT ALPHA TYPE-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PANTR|Ensembl=ENSPTRG00000002086|UniProtKB=H2Q1A9	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_56687|UniProtKB=C3YC50	Putative uncharacterized protein	IDA	3487386	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	HUMAN|HGNC=4587|UniProtKB=Q14957	Glutamate receptor ionotropic, NMDA 2C	ISS	14698601	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00029	Huntington disease	P00812	Caspase 3	CHICK|Ensembl=ENSGALG00000010638|UniProtKB=O93417	Caspase-3	IDA	9323209	PubMed	PTHR10454:SF198	CASPASE-3
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04578	Rho	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	IDA	12169092	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9441|UniProtKB=P51817	cAMP-dependent protein kinase catalytic subunit PRKX	IC	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P02746	Heme biosynthesis	P02983	Hydroxymethylbilane synthase	STRCO|EnsemblGenome=CAB92889|UniProtKB=Q9KY00	Porphobilinogen deaminase 2	ISS			PTHR11557:SF0	PORPHOBILINOGEN DEAMINASE
P05917	Opioid proopiomelanocortin pathway	P06009	K+ channel	RAT|RGD=621451|UniProtKB=Q9ES08	Potassium channel subfamily K member 9	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DICDI|dictyBase=DDB_G0268744|UniProtKB=Q55EU6	Putative actin-23	ISS	11889126	PubMed	PTHR11937:SF154	ACTIN-17-RELATED
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	IDA	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00049	Parkinson disease	P01219	SAPK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00006	Apoptosis signaling pathway	P00265	Granzyme B	PANTR|Ensembl=ENSPTRG00000006226|UniProtKB=H2Q841	Uncharacterized protein	ISS	1985927	PubMed	PTHR24271:SF41	GRANZYME B
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	2837282	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=620807|UniProtKB=P63219	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04395	Vasopressin synthesis	P04591	Pro-Neurophysin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	3768139	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00047	PDGF signaling pathway	P01143	ERK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	HUMAN|HGNC=236|UniProtKB=O95622	Adenylate cyclase type 5	IC	1409703	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00223	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00057	Wnt signaling pathway	P01451	Galpha	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	PANTR|Ensembl=ENSPTRG00000000271|UniProtKB=Q5IS65	5-hydroxytryptamine receptor 6	ISS	12181435	PubMed	PTHR24247:SF114	5-HYDROXYTRYPTAMINE RECEPTOR 6
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CANLF|Ensembl=ENSCAFG00000012181|UniProtKB=F2Z4N7	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	DANRE|ZFIN=ZDB-GENE-030131-9435|UniProtKB=F1R8S3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00018	EGF receptor signaling pathway	P00562	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P06587	Nicotine pharmacodynamics pathway	P06593	CHRNA5	PANTR|Gene=CHRNA5|UniProtKB=Q5IS51	Neuronal acetylcholine receptor subunit alpha-5	ISS	85270494	PubMed	PTHR18945:SF76	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	NAS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05913	Enkephalin release	P05977	G-Protein (s)	MACMU|Ensembl=ENSMMUG00000010266|UniProtKB=F6PV18	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00005	Angiogenesis	P00219	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	MACMU|Ensembl=ENSMMUG00000022513|UniProtKB=F6YNZ0	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00029	Huntington disease	P00811	Arp2/3 complex	ARATH|TAIR=AT2G30910|UniProtKB=O80856	Actin-related protein 2/3 complex subunit 1A	TAS	12963527	gi	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P00021	FGF signaling pathway	P00641	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00059	p53 pathway	P04609	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00013	Cell cycle	P00480	Proteasome	PANTR|Ensembl=ENSPTRG00000009109|UniProtKB=G2HF36	26S proteasome non-ATPase regulatory subunit 3	ISS	4506229	gi	PTHR10758:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	RCA	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00018	EGF receptor signaling pathway	P00557	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01472	Histone deacetylase	CANLF|Ensembl=ENSCAFG00000010597|UniProtKB=J9NUI0	Histone deacetylase	ISS	12665570	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P00047	PDGF signaling pathway	P01148	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8617307	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	HUMAN|HGNC=12441|UniProtKB=P04818	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00049	Parkinson disease	P01233	Elk-1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	IDA	10487205	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00018	EGF receptor signaling pathway	P00547	PP2A	TAKRU|Ensembl=ENSTRUG00000008018|UniProtKB=H2T5N4	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00029	Huntington disease	P00774	Dynein complex	IXOSC|EnsemblGenome=ISCW003606|UniProtKB=B7PJZ9	Dynein light chain	ISS	9454836	PubMed	PTHR11886:SF62	DYNEIN, LIGHT CHAIN, LC8-TYPE 2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	IDA	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00005	Angiogenesis	P00227	PLA2	RAT|RGD=67366|UniProtKB=P50393	Cytosolic phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05731	GABA-B receptor II signaling	P05754	Ggamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	HUMAN|HGNC=237|UniProtKB=O43306	Adenylate cyclase type 6	IC	10978539	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	TAS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IDA	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00056	VEGF signaling pathway	P01411	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00057	Wnt signaling pathway	P01435	SWI/SNF	RAT|RGD=1308832|UniProtKB=F1LNL2	Protein Smarca5	ISS	11532957	PubMed	PTHR10799:SF887	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00047	PDGF signaling pathway	P01154	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00056	VEGF signaling pathway	P01417	Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00004	Alzheimer disease-presenilin pathway	P00114	actin	XENTR|Xenbase=XB-GENE-491618|UniProtKB=Q6P378	Actin, cytoplasmic 2	ISS	3487386	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00054	Toll receptor signaling pathway	P01360	IKKbeta	PANTR|Ensembl=ENSPTRG00000020202|UniProtKB=H2QW34	Uncharacterized protein	ISS	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00780	Microtubule	TRIVA|Gene=TVAG_034440|UniProtKB=A2EM81	Beta-tubulin, putative	IDA	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00047	PDGF signaling pathway	P01143	ERK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04556	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	IDA	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00974	Receptor subunit beta	MOUSE|MGI=MGI=109380|UniProtKB=Q61190	Interleukin-10 receptor subunit beta	IDA	98130620	PubMed	PTHR20859:SF50	INTERLEUKIN-10 RECEPTOR SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00560	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	CAEBR|Gene=CBG02059|UniProtKB=A8WRW6	Protein CBR-UNC-2 (Fragment)	ISS	14624853	PubMed	PTHR10037:SF238	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TRIVA|Gene=TVAG_337240|UniProtKB=P90623	Actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02763	Peptidoglycan biosynthesis	P03090	N-Acetylglucosaminyl transferase	GLOVI|Gene=BAC91170|UniProtKB=Q7NGE2	Glr3229 protein	ISS			PTHR43025:SF4	SUBFAMILY NOT NAMED
P00010	B cell activation	P00372	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8316835	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	DROME|FlyBase=FBgn0004009|UniProtKB=P09615	Protein wingless	TAS	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05916	Opioid prodynorphin pathway	P06002	G-protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00015	Circadian clock system	G01503	per	HUMAN|HGNC=8847|UniProtKB=P56645	Period circadian protein homolog 3	ISS	15700718	PubMed	PTHR11269:SF13	PERIOD CIRCADIAN PROTEIN HOMOLOG 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00024	Glycolysis	P00673	Triosephosphate isomerase	ECOLI|EcoGene=EG11015|UniProtKB=P0A858	Triosephosphate isomerase	RCA			PTHR21139:SF2	TRIOSEPHOSPHATE ISOMERASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	SCHPO|PomBase=SPBC32H8.07|UniProtKB=Q10282	Guanine nucleotide-binding protein subunit beta	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00021	FGF signaling pathway	P00638	PLCgamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	DANRE|ZFIN=ZDB-GENE-040426-2738|UniProtKB=E7FBI4	Uncharacterized protein	ISS			PTHR24070:SF289	SUBFAMILY NOT NAMED
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	MONDO|Ensembl=ENSMODG00000003244|UniProtKB=F6THF0	Uncharacterized protein	ISS	97402517	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00047	PDGF signaling pathway	P01162	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00057	Wnt signaling pathway	P01465	Ggamma	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	MOUSE|MGI=MGI=1339946|UniProtKB=P62340	TATA box-binding protein-like protein 1	ISS	10082669	PubMed	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P02748	Isoleucine biosynthesis	P02994	Branched chain amino acid aminotransferase	YEAST|SGD=S000001251|UniProtKB=P38891	Branched-chain-amino-acid aminotransferase, mitochondrial	ISS			PTHR11825:SF44	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P00057	Wnt signaling pathway	P01457	GBeta	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01395	TFIIE	DROME|FlyBase=FBgn0015828|UniProtKB=O96880	GH11150p	ISS			PTHR13097:SF7	NOVEL PROTEIN SIMILAR TO VERTEBRATE GENERAL TRANSCRIPTION FACTOR IIE POLYPEPTIDE 1 ALPHA 56KDA  GTF2E1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00034	Integrin signalling pathway	P00916	Ras	MONDO|Ensembl=ENSMODG00000025248|UniProtKB=F7F5X1	Uncharacterized protein	ISS	9869449	PubMed	PTHR24070:SF186	GTPASE KRAS
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	XENTR|Xenbase=XB-GENE-485280|UniProtKB=F6X3B2	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	DROME|FlyBase=FBgn0019947|UniProtKB=O02194	Presenilin homolog	IDA	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MOUSE|MGI=MGI=88398|UniProtKB=Q9ERZ3	Muscarinic acetylcholine receptor M3	IDA	10069496	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000005917|UniProtKB=F6QM53	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00005	Angiogenesis	P00256	PLC-gamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00029	Huntington disease	P00780	Microtubule	MONDO|Ensembl=ENSMODG00000024011|UniProtKB=F7CGM4	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00034	Integrin signalling pathway	P00928	alpha actinin	MACMU|Ensembl=ENSMMUG00000020471|UniProtKB=F7GBD5	Uncharacterized protein	ISS	2116421	PubMed	PTHR43947:SF4	ALPHA-ACTININ-2
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	MOUSE|MGI=MGI=95784|UniProtKB=P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MONDO|Ensembl=ENSMODG00000020204|UniProtKB=F6SED9	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	RAT|RGD=2287|UniProtKB=P32232	Cystathionine beta-synthase	ISS			PTHR10314:SF8	CYSTATHIONINE BETA-SYNTHASE-RELATED
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IDA	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IPI	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	HUMAN|HGNC=4401|UniProtKB=O14775	Guanine nucleotide-binding protein subunit beta-5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00004	Alzheimer disease-presenilin pathway	P00114	actin	HUMAN|HGNC=129|UniProtKB=P68133	Actin, alpha skeletal muscle	IDA	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00018	EGF receptor signaling pathway	P00560	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00029	Huntington disease	P00786	ARF	XENTR|Xenbase=XB-GENE-967358|UniProtKB=F6V4X2	Uncharacterized protein (Fragment)	ISS	11752622	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P02725	Allantoin degradation	P02819	Glyoxylate carboligase	ECOLI|EcoGene=EG11583|UniProtKB=P0AEP7	Glyoxylate carboligase	ISS			PTHR18968:SF14	GLYOXYLATE CARBOLIGASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00047	PDGF signaling pathway	P01159	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00561	STAT	BOVIN|Gene=STAT3|UniProtKB=P61635	Signal transducer and activator of transcription 3	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04398	p53 pathway feedback loops 2	P04666	cyclin A	PANTR|Ensembl=ENSPTRG00000005784|UniProtKB=H2Q7F3	Uncharacterized protein	RCA			PTHR10177:SF254	CYCLIN-A1
P00034	Integrin signalling pathway	P00913	Csk	MOUSE|MGI=MGI=88537|UniProtKB=P41241	Tyrosine-protein kinase CSK	IDA	11078745	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MACMU|Ensembl=ENSMMUG00000014754|UniProtKB=F7G124	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF721	MYOSIN-6
P05913	Enkephalin release	G06045	preproenkephalin	MOUSE|MGI=MGI=104629|UniProtKB=P22005	Proenkephalin-A	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	CAEEL|WormBase=WBGene00000295|UniProtKB=Q9GNP0	Uncharacterized protein	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	TAKRU|Ensembl=ENSTRUG00000011562|UniProtKB=H2TX02	Protein Wnt	TAS	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00018	EGF receptor signaling pathway	P00562	p38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00010	B cell activation	P00381	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00385	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	15470041	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00010	B cell activation	P00384	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00046	Oxidative stress response	P01129	JNK1/2	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00005	Angiogenesis	P00247	Tie2	DANRE|ZFIN=ZDB-GENE-990415-56|UniProtKB=O73791	Tyrosine-protein kinase receptor Tie-2	ISS			PTHR24416:SF125	ANGIOPOIETIN-1 RECEPTOR
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00049	Parkinson disease	P01232	CASK	PANTR|Ensembl=ENSPTRG00000021812|UniProtKB=H2R4R8	Uncharacterized protein	ISS	11679592	PubMed	PTHR23122:SF40	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00036	Interleukin signaling pathway	P00973	PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00205	GAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	ISS	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P02771	Pyrimidine Metabolism	P03129	Aminotransferase	CANLF|Ensembl=ENSCAFG00000019030|UniProtKB=E2R776	Uncharacterized protein	ISS	8133261	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00047	PDGF signaling pathway	P01162	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00087	Fe65	MOUSE|MGI=MGI=107765|UniProtKB=Q9QXJ1	Amyloid beta A4 precursor protein-binding family B member 1	IDA	11441186	PubMed	PTHR14058:SF5	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	BOVIN|Ensembl=ENSBTAG00000019832|UniProtKB=G3MZV8	TGF-beta receptor type-2	ISS	9759503	PubMed	PTHR23255:SF55	TGF-BETA RECEPTOR TYPE-2
P00034	Integrin signalling pathway	P00923	Arf1	DANRE|ZFIN=ZDB-GENE-030131-5234|UniProtKB=Q7ZUZ7	ADP-ribosylation factor 1	ISS	11752622	PubMed	PTHR11711:SF291	ADP-RIBOSYLATION FACTOR 1
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	XENTR|Xenbase=XB-GENE-6454420|UniProtKB=F6WZT5	Uncharacterized protein	ISS			PTHR11482:SF4	ANTIZYME INHIBITOR 2
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00056	VEGF signaling pathway	P01407	Erk	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00011	Blood coagulation	P00424	uPA	MACMU|Ensembl=ENSMMUG00000009906|UniProtKB=F6YDX7	Uncharacterized protein	ISS	137114	gi	PTHR24264:SF38	UROKINASE-TYPE PLASMINOGEN ACTIVATOR
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CANLF|Ensembl=ENSCAFG00000015708|UniProtKB=F2Z4N0	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	ARATH|TAIR=AT2G23070|UniProtKB=O64816	Casein kinase II subunit alpha, chloroplastic	IDA	10806215	PubMed	PTHR24054:SF33	CASEIN KINASE II SUBUNIT ALPHA, CHLOROPLASTIC
P00030	Hypoxia response via HIF activation	P00817	TOR	MONDO|Ensembl=ENSMODG00000011138|UniProtKB=F7BA89	Uncharacterized protein	ISS	7518356	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00875	GEF	HUMAN|HGNC=12657|UniProtKB=P15498	Proto-oncogene vav	ISS	10661401	PubMed	PTHR22826:SF112	PROTO-ONCOGENE VAV
P00021	FGF signaling pathway	P00644	p38	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	IGI	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00048	PI3 kinase pathway	P01188	Gbetagamma	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	94280860	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00047	PDGF signaling pathway	P01146	Ikk	HUMAN|HGNC=5959|UniProtKB=O95163	Elongator complex protein 1	ISS			PTHR12747:SF0	ELONGATOR COMPLEX PROTEIN 1
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Gene=PCDHB8|UniProtKB=Q5DRC6	Protocadherin beta-8	ISS	8120095	PubMed	PTHR24028:SF150	PROTOCADHERIN BETA-8
P00045	Notch signaling pathway	P01104	Serrate	RAT|RGD=2938|UniProtKB=P97607	Protein jagged-2 (Fragment)	IDA	12826675	PubMed	PTHR44097:SF1	PROTEIN JAGGED-2
P00034	Integrin signalling pathway	P00941	Integrin alpha	BOVIN|Ensembl=ENSBTAG00000016525|UniProtKB=F1MMN6	Uncharacterized protein	ISS	3487386	PubMed	PTHR23220:SF22	INTEGRIN ALPHA-1
P00029	Huntington disease	P00775	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P02770	Pyridoxal phosphate salvage pathway	P03120	Pyridoxamine-5-phosphate oxidase	MACMU|Ensembl=ENSMMUG00000003325|UniProtKB=F7EHD9	Pyridoxine-5'-phosphate oxidase	ISS	9601034	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00034	Integrin signalling pathway	P00921	PINCH	MOUSE|MGI=MGI=2385067|UniProtKB=Q91XD2	LIM and senescent cell antigen-like-containing domain protein 2	IPI	10022929	PubMed	PTHR24210:SF10	LIM AND SENESCENT CELL ANTIGEN-LIKE-CONTAINING DOMAIN PROTEIN 2
P00054	Toll receptor signaling pathway	P01352	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	PANTR|Ensembl=ENSPTRG00000001756|UniProtKB=H2Q0Q7	Regulator of G-protein signaling 16	ISS	8756726	PubMed	PTHR10845:SF187	REGULATOR OF G-PROTEIN SIGNALING 16
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00236	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00024	Glycolysis	P00677	Hexokinase	MACMU|Ensembl=ENSMMUG00000003849|UniProtKB=F7HAC6	Uncharacterized protein	RCA			PTHR19443:SF28	HEXOKINASE HKDC1-RELATED
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MONDO|Ensembl=ENSMODG00000016396|UniProtKB=F7E905	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	IC	91072385	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00056	VEGF signaling pathway	P01422	eNOS	MACMU|Ensembl=ENSMMUG00000020437|UniProtKB=F6WEB2	Nitric oxide synthase	ISS	9837777	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00047	PDGF signaling pathway	P01142	p90RSK	MACMU|Ensembl=ENSMMUG00000022111|UniProtKB=F7H7W3	Ribosomal protein S6 kinase	ISS	7688567	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	TAS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00048	PI3 kinase pathway	P01206	14-3-3	HUMAN|HGNC=12855|UniProtKB=P63104	14-3-3 protein zeta/delta	ISS	12615066	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P06664	Gonadotropin-releasing hormone receptor pathway	P06852	nPKCs	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	RCA	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	PYRAE|EnsemblGenome=PAE0798|UniProtKB=Q8ZYF9	Serine hydroxymethyltransferase	ISS			PTHR11680:SF21	SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00890	ELK	STRPU|EnsemblGenome=SPU_012469|UniProtKB=Q95UJ1	Transcription factor Elk	ISS	11279280	PubMed	PTHR11849:SF133	LIN-1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MACMU|Ensembl=ENSMMUG00000009287|UniProtKB=F7H3T9	Glutamate receptor 1 isoform 1	ISS	10331083	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	PANTR|Ensembl=ENSPTRG00000019449|UniProtKB=H2QV01	Actin related protein 2/3 complex, subunit 1B, 41kDa	ISS	9618202	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00021	FGF signaling pathway	P00632	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IGI	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00021	FGF signaling pathway	P00628	JNK1-3	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS			PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	XENTR|Xenbase=XB-GENE-6259095|UniProtKB=Q5BL39	Tubulin, beta 2	ISS	9454836	PubMed	PTHR11588:SF93	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00564	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	15470041	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00010	B cell activation	P00381	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00925	MEK	HUMAN|HGNC=6844|UniProtKB=P45985	Dual specificity mitogen-activated protein kinase kinase 4	IDA	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00012	Cadherin signaling pathway	P00463	betacatenin	HUMAN|HGNC=2514|UniProtKB=P35222	Catenin beta-1	IDA	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P00046	Oxidative stress response	P01129	JNK1/2	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	TAS	11707292	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00048	PI3 kinase pathway	P01185	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00059	p53 pathway	P01486	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00830	Lipoxygenase	RAT|RGD=620677|UniProtKB=Q925U2	Leukotriene C4 synthase	ISS	11897981	PubMed	PTHR10250:SF4	LEUKOTRIENE C4 SYNTHASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00777	CBP	RAT|RGD=2401|UniProtKB=Q6JHU9	CREB-binding protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00018	EGF receptor signaling pathway	P00561	STAT	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	IDA	3045562	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	HUMAN|HGNC=1953|UniProtKB=P08173	Muscarinic acetylcholine receptor M4	TAS	91373358	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P05913	Enkephalin release	P05974	G-Protein (i)	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P05913	Enkephalin release	P05975	GPCR (s)	MONDO|Ensembl=ENSMODG00000008382|UniProtKB=F7CDR6	Uncharacterized protein (Fragment)	ISS	11259498	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00053	T cell activation	P01307	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	IPI	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	RCA	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000006582|UniProtKB=E1BFV6	Uncharacterized protein	ISS	12562507	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02916	dTMP kinase	METAC|EnsemblGenome=MA_4433|UniProtKB=Q8THS9	Probable thymidylate kinase	ISS			PTHR10344:SF1	THYMIDYLATE KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	IC	2372396	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MOUSE|MGI=MGI=1336171|UniProtKB=Q9DAS9	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IDA	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	HUMAN|HGNC=1736|UniProtKB=P60953	Cell division control protein 42 homolog	IDA	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00060	Ubiquitin proteasome pathway	P01494	19S proteasome	TRYB2|Gene=Tb927.6.1090|UniProtKB=D6XHJ3	Proteasome regulatory ATPase subunit 3	ISS			PTHR23073:SF8	26S PROTEASE REGULATORY SUBUNIT 6B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	BOVIN|Ensembl=ENSBTAG00000006143|UniProtKB=E1BNX4	Uncharacterized protein	RCA			PTHR22952:SF24	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	10891487	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00018	EGF receptor signaling pathway	P00562	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00049	Parkinson disease	P01211	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00018	EGF receptor signaling pathway	P00551	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008018|UniProtKB=F7EPG4	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00057	Wnt signaling pathway	P01457	GBeta	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P06587	Nicotine pharmacodynamics pathway	P06596	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12186904	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00021	FGF signaling pathway	P00643	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04559	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00059	p53 pathway	P04609	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	129387	gi	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	TAKRU|Ensembl=ENSTRUG00000005596|UniProtKB=H2SM61	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00053	T cell activation	P01314	nck	CHICK|Ensembl=ENSGALG00000016799|UniProtKB=F1P4Q4	Uncharacterized protein	ISS	12874226	PubMed	PTHR44108:SF1	CYTOPLASMIC PROTEIN NCK2
P02742	Tetrahydrofolate biosynthesis	P02946	5-Hydroxymethyl-7,8-dihydropteridine pyrophosphokinase	DEIRA|EnsemblGenome=DR_0170|UniProtKB=Q9RXY4	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	ISS			PTHR43071:SF1	2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	BOVIN|Ensembl=ENSBTAG00000008027|UniProtKB=P01180	Vasopressin-neurophysin 2-copeptin	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_127488|UniProtKB=C3XYC7	Putative uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00046	Oxidative stress response	P01129	JNK1/2	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS			PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00045	Notch signaling pathway	P01099	Notch	RAT|RGD=3187|UniProtKB=Q07008	Neurogenic locus notch homolog protein 1	IEP	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00047	PDGF signaling pathway	P01175	Shc	HUMAN|HGNC=18181|UniProtKB=Q92529	SHC-transforming protein 3	ISS	96404502	PubMed	PTHR10337:SF4	SHC-TRANSFORMING PROTEIN 3
P00018	EGF receptor signaling pathway	P00565	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	METAC|EnsemblGenome=MA_4118|UniProtKB=Q8TIM8	Adenylosuccinate synthetase 2	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	HUMAN|HGNC=712|UniProtKB=P32121	Beta-arrestin-2	IDA	12464600	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00059	p53 pathway	G04694	p110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00048	PI3 kinase pathway	P01189	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00048	PI3 kinase pathway	P01194	S6K	MACMU|Ensembl=ENSMMUG00000019305|UniProtKB=F6S3T8	Ribosomal protein S6 kinase	ISS	15116068	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00549	EGF	RAT|RGD=2542|UniProtKB=P07522	Pro-epidermal growth factor	RCA			PTHR44717:SF1	PRO-EPIDERMAL GROWTH FACTOR
P00029	Huntington disease	P00790	beta-Tubulin	PHYPA|Gene=PHYPADRAFT_232451|UniProtKB=A9SKU2	Predicted protein	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P02749	Leucine biosynthesis	P02999	2-Isopropylmalate synthase	STRCO|EnsemblGenome=CAD55194|UniProtKB=O31046	2-isopropylmalate synthase	ISS			PTHR10277:SF56	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000001962|UniProtKB=F6V2H6	Uncharacterized protein	ISS	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00029	Huntington disease	P00790	beta-Tubulin	DROME|FlyBase=FBgn0003888|UniProtKB=P08841	Tubulin beta-3 chain	TAS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05915	Opioid proenkephalin pathway	P05994	G-protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01169	Vav	MACMU|Ensembl=ENSMMUG00000017214|UniProtKB=F7HEA0	Uncharacterized protein	ISS	14623913	PubMed	PTHR22826:SF95	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV2
P04393	Ras Pathway	P04570	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P02743	Formyltetrahydroformate biosynthesis	P02954	Thymidylate synthase	PLAF7|EnsemblGenome=PFD0830w|UniProtKB=Q8I1R6	Bifunctional dihydrofolate reductase-thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00036	Interleukin signaling pathway	P00996	STAT	MOUSE|MGI=MGI=103035|UniProtKB=P42232	Signal transducer and activator of transcription 5B	IC	22320921	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P02736	Coenzyme A biosynthesis	P02884	Dephospho-CoA kinase	SYNY3|EnsemblGenome=BAA10873|UniProtKB=Q55515	Dephospho-CoA kinase	ISS			PTHR10695:SF26	BIFUNCTIONAL COENZYME A SYNTHASE
P02738	De novo purine biosynthesis	P02906	N5-carboxyaminoimidazole ribonucleotide synthase	AQUAE|EnsemblGenome=aq_1178|UniProtKB=O67239	N5-carboxyaminoimidazole ribonucleotide mutase	ISS			PTHR23046:SF2	N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE MUTASE
P00019	Endothelin signaling pathway	P00578	eNOS	PANTR|Ensembl=ENSPTRG00000019868|UniProtKB=H2QVM2	Nitric oxide synthase	ISS	9837777	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00018	EGF receptor signaling pathway	P00539	14-3-3	PANTR|Ensembl=ENSPTRG00000011641|UniProtKB=H2QHF1	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	ISS	5803227	gi	PTHR18860:SF3	14-3-3 PROTEIN THETA
P00049	Parkinson disease	P01211	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01198	FOXO	PANTR|Ensembl=ENSPTRG00000018476|UniProtKB=H2R710	Forkhead box O3	ISS	12048180	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00022	General transcription by RNA polymerase I	P00657	TBP	ARATH|TAIR=AT1G55520|UniProtKB=P28148	TATA-box-binding protein 2	ISS	600075	OMIM	PTHR10126:SF36	TATA-BOX-BINDING PROTEIN 1-RELATED
P02747	Histidine biosynthesis	P02988	Histidinal dehydrogenase	RHOBA|EnsemblGenome=RB1584|UniProtKB=Q7UX39	Histidinol dehydrogenase	ISS			PTHR21256:SF2	HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00269	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CAEEL|WormBase=WBGene00001187|UniProtKB=Q8MQA1	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P02775	Salvage pyrimidine ribonucleotides	P03150	Uridine kinase	ORYSJ|EnsemblGenome=OS02G0708200|UniProtKB=Q6YV21	Os02g0708200 protein	ISS			PTHR10285:SF122	URIDINE-CYTIDINE KINASE C
P00019	Endothelin signaling pathway	P00566	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	12471242	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	MOUSE|MGI=MGI=88274|UniProtKB=P26231	Catenin alpha-1	TAS	1904011	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P04393	Ras Pathway	P04567	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00060	Ubiquitin proteasome pathway	P01492	E1	RAT|RGD=621084|UniProtKB=Q99MI7	NEDD8-activating enzyme E1 catalytic subunit	ISS			PTHR10953:SF6	NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	ANOGA|EnsemblGenome=AGAP001306|UniProtKB=Q7PUB7	Actin-related protein 2/3 complex subunit 4	ISS	5031595	gi	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04566	Stat 1/3	MONDO|Ensembl=ENSMODG00000028212|UniProtKB=F7BYN4	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P02723	Adenine and hypoxanthine salvage pathway	P02807	Deoxyadenosine deaminase	YEAST|SGD=S000005085|UniProtKB=P53909	Adenine deaminase	ISS			PTHR43114:SF2	ADENINE DEAMINASE
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	CANLF|Ensembl=ENSCAFG00000016466|UniProtKB=F1PGT3	Uncharacterized protein	ISS	14724059	PubMed	PTHR11699:SF102	RETINAL DEHYDROGENASE 2
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	MOUSE|MGI=MGI=1276116|UniProtKB=B2RWS6	Histone acetyltransferase p300	ISS	10664585	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00045	Notch signaling pathway	P01117	Neuralized	HUMAN|HGNC=7761|UniProtKB=O76050	E3 ubiquitin-protein ligase NEURL1	RCA			PTHR12429:SF13	E3 UBIQUITIN-PROTEIN LIGASE NEURL1
P00006	Apoptosis signaling pathway	P00269	MAPK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04556	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	TAKRU|Ensembl=ENSTRUG00000007253|UniProtKB=H2SZQ1	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00006	Apoptosis signaling pathway	P00321	HSP70	CAEEL|WormBase=WBGene00002026|UniProtKB=O45246	Heat Shock Protein	ISS	12150907	PubMed	PTHR19375:SF207	HEAT SHOCK PROTEIN
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	CHICK|Ensembl=ENSGALG00000014033|UniProtKB=E1BTS2	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01188	Gbetagamma	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00036	Interleukin signaling pathway	P00970	Interleukin	MOUSE|MGI=MGI=107364|UniProtKB=Q62386	Interleukin-17A	TAS	8877732	PubMed	PTHR44866:SF1	INTERLEUKIN-17A
P02723	Adenine and hypoxanthine salvage pathway	P02804	Hypoxanthine phosphoribosyl transferase	HUMAN|HGNC=5157|UniProtKB=P00492	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF6	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE
P00050	Plasminogen activating cascade	P01250	MMP-13	CANLF|Ensembl=ENSCAFG00000015043|UniProtKB=F1PVS9	Uncharacterized protein	TAS	Fang,Y.,Kitchell,B.E.,Paria,B.andBalkin,R.	free text	PTHR10201:SF165	COLLAGENASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	RAT|RGD=620465|UniProtKB=O08565	C-X-C chemokine receptor type 4	ISS	11943720	PubMed	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	PANTR|Ensembl=ENSPTRG00000010617|UniProtKB=H2QFL8	Notch 3	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00047	PDGF signaling pathway	P01143	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	MACMU|Gene=CXCL10|UniProtKB=Q8MIZ1	C-X-C motif chemokine 10	ISS	10946576	gi	PTHR10179:SF47	C-X-C MOTIF CHEMOKINE 10
P00021	FGF signaling pathway	P00641	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	RAT|RGD=620023|UniProtKB=P10980	Muscarinic acetylcholine receptor M2	ISS	10069496	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00021	FGF signaling pathway	P00630	RKIP	DROME|FlyBase=FBgn0038973|UniProtKB=Q9VD01	LP12095p	ISS			PTHR11362:SF28	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MACMU|Ensembl=ENSMMUG00000018497|UniProtKB=F7A9J8	Serine/threonine-protein kinase receptor	ISS	9395284	PubMed	PTHR23255:SF69	ACTIVIN RECEPTOR TYPE-1
P00048	PI3 kinase pathway	P01206	14-3-3	CAEEL|WormBase=WBGene00001502|UniProtKB=Q20655	14-3-3-like protein 2	ISS	97315111	PubMed	PTHR18860:SF13	14-3-3 PROTEIN ZETA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	2574500	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P02755	Methylmalonyl pathway	P03034	Methylmalonyl-CoA mutase	STRCO|Gene=CAB71920|UniProtKB=Q9L1V3	Methylmalonyll-CoA mutase	ISS			PTHR43589:SF3	SUBFAMILY NOT NAMED
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	DEIRA|EnsemblGenome=DR_2471|UniProtKB=Q9RRL7	Acetyl-coenzyme A synthetase	ISS			PTHR24095:SF14	ACETYL-COENZYME A SYNTHETASE 1
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	PANTR|Ensembl=ENSPTRG00000010617|UniProtKB=H2QFL8	Notch 3	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00019	Endothelin signaling pathway	P00572	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02726	Aminobutyrate degradation	P02824	Succinate semi-aldehyde dehydrogenase	DICDI|dictyBase=DDB_G0276305|UniProtKB=Q551V0	Aldehyde dehydrogenase	ISS			PTHR11699:SF65	ALDEHYDE DEHYDROGENASE
P02738	De novo purine biosynthesis	P02902	ADP reductase	YEAST|SGD=S000003412|UniProtKB=P49723	Ribonucleoside-diphosphate reductase small chain 2	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	IC	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	MOUSE|MGI=MGI=109482|UniProtKB=P97445	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	15699344	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00018	EGF receptor signaling pathway	P00557	PI3K	CANAL|CGD=CAL0068551|UniProtKB=Q5AAR9	Phosphatidylinositol 3-kinase	IGI	10870104	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	HUMAN|HGNC=14261|UniProtKB=Q9NS28	Regulator of G-protein signaling 18	IDA	8756726	PubMed	PTHR10845:SF155	REGULATOR OF G-PROTEIN SIGNALING 18
P02756	N-acetylglucosamine metabolism	P03041	Glucosamine-6-phosphate deaminase	CAEEL|WormBase=WBGene00011399|UniProtKB=Q9XVJ2	Probable glucosamine-6-phosphate isomerase	ISS			PTHR11280:SF17	GLUCOSAMINE-6-PHOSPHATE ISOMERASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	CANLF|Ensembl=ENSCAFG00000010787|UniProtKB=E2R3W6	Uncharacterized protein	ISS	2039532	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	CAEEL|WormBase=WBGene00014058|UniProtKB=Q09629	Probable adenylate kinase isoenzyme ZK673.2	ISS			PTHR23359:SF145	GTP:AMP PHOSPHOTRANSFERASE, MITOCHONDRIAL
P00049	Parkinson disease	P01238	14-3-3	CAEBR|Gene=CBG06174|UniProtKB=A8X0R4	Protein CBR-PAR-5	ISS	10407019	PubMed	PTHR18860:SF21	14-3-3-LIKE PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DROME|FlyBase=FBgn0261854|UniProtKB=A1Z9X0	Atypical protein kinase C	ISS	3045562	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00021	FGF signaling pathway	P00642	MEK1-2	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00005	Angiogenesis	P00188	Ets	MACMU|Ensembl=ENSMMUG00000020706|UniProtKB=F6PU72	Uncharacterized protein	ISS	15579511	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00053	T cell activation	P01320	PLC-gamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00048	PI3 kinase pathway	P01179	PKB	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	PANTR|Gene=CHRNA5|UniProtKB=Q5IS51	Neuronal acetylcholine receptor subunit alpha-5	ISS	12388584	PubMed	PTHR18945:SF76	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5
P00051	TCA cycle	P01271	Fumarase	CANLF|Ensembl=ENSCAFG00000015704|UniProtKB=E2RGR9	Uncharacterized protein	ISS	227665	gi	PTHR11444:SF1	FUMARATE HYDRATASE, MITOCHONDRIAL
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00009	Axon guidance mediated by netrin	P00359	NFAT	MOUSE|MGI=MGI=103296|UniProtKB=P97305	Nuclear factor of activated T-cells, cytoplasmic 3	IDA	9133421	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00057	Wnt signaling pathway	P01446	Calcineurin	MOUSE|MGI=MGI=107163|UniProtKB=P48453	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	IDA	12015605	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01444	Wnt	BOVIN|Ensembl=ENSBTAG00000020221|UniProtKB=E1BDG5	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000019361|UniProtKB=H2QUV3	Uncharacterized protein	ISS	20012997	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	MOUSE|MGI=MGI=2150393|UniProtKB=Q91ZU9	Glutamate receptor ionotropic, NMDA 3B	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P00004	Alzheimer disease-presenilin pathway	P00117	E-cadherin C-terminal fragment	RAT|RGD=621089|UniProtKB=F1LMI3	Cadherin 3, type 1, P-cadherin (Placental)	ISS	11953314	PubMed	PTHR24027:SF267	CADHERIN-3
P06587	Nicotine pharmacodynamics pathway	P06602	PPP1CA	BOVIN|Ensembl=ENSBTAG00000011198|UniProtKB=P61287	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	ISS	10433257	PubMed	PTHR11668:SF204	SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-GAMMA CATALYTIC SUBUNIT
P00021	FGF signaling pathway	P00632	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05918	p38 MAPK pathway	P06015	p38gamma	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANAL|CGD=CAL0003231|UniProtKB=Q5ANK2	Protein kinase C	TAS	11554554	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CANAL|CGD=CAL0064759|UniProtKB=Q5AKX0	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	P01434	sFRP	PANTR|Ensembl=ENSPTRG00000016530|UniProtKB=H2QQB0	Secreted frizzled-related protein 2	ISS	9096311	PubMed	PTHR11309:SF45	SECRETED FRIZZLED-RELATED PROTEIN 2
P00021	FGF signaling pathway	P00636	FGFR1-4	MOUSE|MGI=MGI=95523|UniProtKB=P21803	Fibroblast growth factor receptor 2	IPI	1373495	PubMed	PTHR24416:SF130	FIBROBLAST GROWTH FACTOR RECEPTOR 2
P00004	Alzheimer disease-presenilin pathway	P00110	Ire-1 N-terminal fragment	RAT|RGD=1559716|UniProtKB=A0A0G2K2H4	Protein Ern1	ISS	10619423	PubMed	PTHR13954:SF17	SERINE/THREONINE-PROTEIN KINASE/ENDORIBONUCLEASE IRE1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00089	Pen-2	CANLF|Ensembl=ENSCAFG00000032463|UniProtKB=J9P0J9	Presenilin enhancer	ISS	12110170	PubMed	PTHR16318:SF0	GAMMA-SECRETASE SUBUNIT PEN-2
P00018	EGF receptor signaling pathway	P00539	14-3-3	BOVIN|Ensembl=ENSBTAG00000002108|UniProtKB=Q3SZI4	14-3-3 protein theta	ISS	5803227	gi	PTHR18860:SF3	14-3-3 PROTEIN THETA
P00047	PDGF signaling pathway	P01167	Ets	CANLF|Ensembl=ENSCAFG00000009912|UniProtKB=F1PHH8	Potassium voltage-gated channel subfamily H member 2	ISS	15298723	PubMed	PTHR11849:SF216	TRANSCRIPTIONAL REGULATOR ERG
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P06587	Nicotine pharmacodynamics pathway	P06602	PPP1CA	TRIAD|EnsemblGenome=TriadG30170|UniProtKB=B3S6H7	Serine/threonine-protein phosphatase	ISS	8392016	PubMed	PTHR11668:SF402	SERINE/THREONINE-PROTEIN PHOSPHATASE
P00048	PI3 kinase pathway	P01177	P110ACT	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00976	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CHICK|Ensembl=ENSGALG00000011809|UniProtKB=F1NMB0	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	IC	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00046	Oxidative stress response	P01131	MKP5	MOUSE|MGI=MGI=1915926|UniProtKB=Q99N11	Dual specificity protein phosphatase 22	ISS			PTHR10159:SF29	DUAL SPECIFICITY PROTEIN PHOSPHATASE 22
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	BOVIN|Ensembl=ENSBTAG00000002107|UniProtKB=A7MB15	FZD1 protein	ISS	11212302	PubMed	PTHR11309:SF81	FRIZZLED-1
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00029	Huntington disease	P00805	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	IC	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00050	Plasminogen activating cascade	P01246	Plasmin	BOVIN|Gene=PLG|UniProtKB=P06868	Plasminogen	ISS	85203906	PubMed	PTHR24261:SF5	PLASMINOGEN
P04393	Ras Pathway	P04558	p38	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00053	T cell activation	P01300	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05731	GABA-B receptor II signaling	P05753	Ca channel	HUMAN|HGNC=1389|UniProtKB=Q00975	Voltage-dependent N-type calcium channel subunit alpha-1B	TAS	11976940	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00025	Hedgehog signaling pathway	P00682	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05916	Opioid prodynorphin pathway	P05999	provasopressin	CHICK|Ensembl=ENSGALG00000014117|UniProtKB=P24787	Vasotocin-neurophysin VT	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MACMU|Ensembl=ENSMMUG00000007027|UniProtKB=F7F210	Alpha-cardiac actin	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00010	B cell activation	P00398	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IGI	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00012	Cadherin signaling pathway	P00471	Cadherin	MONDO|Ensembl=ENSMODG00000007312|UniProtKB=F7EXZ6	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF273	CADHERIN-8
P00029	Huntington disease	P00807	Actin	CANLF|Ensembl=ENSCAFG00000003197|UniProtKB=E2QXY7	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00053	T cell activation	P01336	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00807	Actin	MACMU|Ensembl=ENSMMUG00000009341|UniProtKB=F6UA54	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MOUSE|MGI=MGI=101848|UniProtKB=P62881	Guanine nucleotide-binding protein subunit beta-5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00005	Angiogenesis	P00221	JNK1	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00020	FAS signaling pathway	P00615	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00059	p53 pathway	P04623	CBP	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	DROME|FlyBase=FBgn0000117|UniProtKB=P18824	Armadillo segment polarity protein	TAS			PTHR23315:SF233	ARMADILLO SEGMENT POLARITY PROTEIN
P00005	Angiogenesis	P00243	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	G01511	SPRY	HUMAN|HGNC=11269|UniProtKB=O43609	Protein sprouty homolog 1	IGI	98117253	PubMed	PTHR12365:SF10	PROTEIN SPROUTY HOMOLOG 1
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2521|UniProtKB=P19020	D(3) dopamine receptor	IDA	2137198	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00006	Apoptosis signaling pathway	P00310	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00009	Axon guidance mediated by netrin	P00366	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00013	Cell cycle	P00483	Cyclin E	CHICK|Gene=CCNE1|UniProtKB=P49707	G1/S-specific cyclin-E1	NAS	12628165	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P05918	p38 MAPK pathway	P06020	p38delta	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	RCA	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04570	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	HUMAN|HGNC=9509|UniProtKB=P49810	Presenilin-2	IDA	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00018	EGF receptor signaling pathway	P00557	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	9395335	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00059	p53 pathway	P01486	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00014	Cholesterol biosynthesis	P00495	Isopentenyl diphosphate delta-isomerase	MOUSE|MGI=MGI=2442264|UniProtKB=P58044	Isopentenyl-diphosphate Delta-isomerase 1	ISS	6225528	gi	PTHR10885:SF5	ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE 1
P00012	Cadherin signaling pathway	P00470	F-actin	TRYB2|Gene=Tb09.211.0620|UniProtKB=Q38E94	Actin A	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	TAKRU|Ensembl=ENSTRUG00000005608|UniProtKB=H2SM93	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MACMU|Ensembl=ENSMMUG00000020084|UniProtKB=F7GP56	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF427	MYOSIN-3
P00049	Parkinson disease	P01238	14-3-3	MACMU|Ensembl=ENSMMUG00000006489|UniProtKB=F7EFF6	14-3-3 protein zeta/delta	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P04393	Ras Pathway	P04547	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	CHICK|Ensembl=ENSGALG00000010812|UniProtKB=F1NLZ9	Uncharacterized protein	ISS	15858232	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00021	FGF signaling pathway	P00629	PP2A	TAKRU|Ensembl=ENSTRUG00000011169|UniProtKB=H2TU36	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P04623	CBP	HUMAN|HGNC=17582|UniProtKB=Q8WYB5	Histone acetyltransferase KAT6B	IDA	10769018	PubMed	PTHR10615:SF73	HISTONE ACETYLTRANSFERASE KAT6B
P00034	Integrin signalling pathway	P00924	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00020	FAS signaling pathway	P00615	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00029	Huntington disease	P00790	beta-Tubulin	PRIPA|Gene=PPA02894|UniProtKB=H3DZP3	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF120	SUBFAMILY NOT NAMED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	HUMAN|HGNC=6091|UniProtKB=P06213	Insulin receptor	ISS	249616	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00047	PDGF signaling pathway	P01153	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00034	Integrin signalling pathway	P00936	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00586	Gq	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	HUMAN|HGNC=8568|UniProtKB=P09958	Furin	IDA	10956649	PubMed	PTHR42884:SF1	FURIN
P00057	Wnt signaling pathway	P01451	Galpha	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01211	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00014	Cholesterol biosynthesis	P00500	Phosphomevalonate kinase	BOVIN|Gene=PMVK|UniProtKB=Q2KIU2	Phosphomevalonate kinase	ISS			PTHR13101:SF1	PHOSPHOMEVALONATE KINASE
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	IDA	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00005	Angiogenesis	P00243	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02743	Formyltetrahydroformate biosynthesis	P02952	Methylene tetrahydrofolate dehydrogenase	HUMAN|HGNC=7434|UniProtKB=P13995	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	ISS			PTHR10025:SF39	BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, MITOCHONDRIAL
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	MACMU|Ensembl=ENSMMUG00000006132|UniProtKB=F7AZ71	Uncharacterized protein	ISS	9388255	PubMed	PTHR10639:SF1	CLATHRIN LIGHT CHAIN A
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00059	p53 pathway	G04694	p110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MONDO|Ensembl=ENSMODG00000001430|UniProtKB=F7BCI5	Uncharacterized protein	ISS	8163524	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00052	TGF-beta signaling pathway	P01290	TAB	CANLF|Ensembl=ENSCAFG00000001332|UniProtKB=F1PLP7	Uncharacterized protein	ISS	10838074	PubMed	PTHR13832:SF533	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1
P00029	Huntington disease	P00779	TBP	ENTHI|Gene=EHI_112050|UniProtKB=C4M7H7	TATA-box-binding protein 2	IPI	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=4596|UniProtKB=Q14833	Metabotropic glutamate receptor 4	IDA	12351712	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00047	PDGF signaling pathway	P01174	Rho	HUMAN|HGNC=26545|UniProtKB=A6NI28	Rho GTPase-activating protein 42	ISS			PTHR12552:SF3	RHO GTPASE-ACTIVATING PROTEIN 42
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00049	Parkinson disease	P01208	Hsp70	ORNAN|Ensembl=ENSOANG00000009457|UniProtKB=F6ZXI7	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF216	HEAT SHOCK-RELATED 70 KDA PROTEIN 2
P00019	Endothelin signaling pathway	P00591	PLCbeta	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00057	Wnt signaling pathway	P01433	SIAH-1	MACMU|Ensembl=ENSMMUG00000007400|UniProtKB=F6T3K3	E3 ubiquitin-protein ligase	ISS	14985507	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P02738	De novo purine biosynthesis	P02891	GDP kinase	ORNAN|Ensembl=ENSOANG00000011750|UniProtKB=F6TWB9	Nucleoside diphosphate kinase	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P00057	Wnt signaling pathway	P01443	Phospholipase C	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00717	Phosphorylase b	MONDO|Ensembl=ENSMODG00000013150|UniProtKB=F7ACG9	Alpha-1,4 glucan phosphorylase	ISS	4318782	PubMed	PTHR11468:SF12	GLYCOGEN PHOSPHORYLASE, LIVER FORM
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00021	FGF signaling pathway	P00644	p38	DANRE|ZFIN=ZDB-GENE-990415-257|UniProtKB=O42376	Mitogen-activated protein kinase 12	ISS	10514528	PubMed	PTHR24055:SF339	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00020	FAS signaling pathway	P00620	CytochromeC	LEIMA|EnsemblGenome=LmjF.07.0060|UniProtKB=Q4QIT8	Putative cytochrome c1, heme protein,mitochondrial	ISS	15163634	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00049	Parkinson disease	P01211	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00292	IkappaB	MOUSE|MGI=MGI=104741|UniProtKB=Q9Z1E3	NF-kappa-B inhibitor alpha	ISS	14665694	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	129387	gi	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	IDA	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	HUMAN|HGNC=9509|UniProtKB=P49810	Presenilin-2	TAS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	HUMAN|HGNC=4540|UniProtKB=P49682	C-X-C chemokine receptor type 3	ISS	6753458	gi	PTHR10489:SF671	C-X-C CHEMOKINE RECEPTOR TYPE 3
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=98959|UniProtKB=P22726	Protein Wnt-5b	TAS	8717036	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P02746	Heme biosynthesis	P02979	porphobilinogen synthase	PLAF7|EnsemblGenome=PF14_0381|UniProtKB=Q8IL68	Delta-aminolevulinic acid dehydratase	ISS			PTHR11458:SF0	DELTA-AMINOLEVULINIC ACID DEHYDRATASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000023112|UniProtKB=B0S4P2	Alpha-1a adrenoceptor transcript variant 1	ISS			PTHR24248:SF16	ALPHA-1A ADRENERGIC RECEPTOR
P00059	p53 pathway	P04623	CBP	CAEEL|WormBase=WBGene00009595|UniProtKB=Q7JMS5	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00023	General transcription regulation	P00668	TFIIB	HUMAN|HGNC=29523|UniProtKB=Q9Y6A4	Cilia- and flagella-associated protein 20	ISS			PTHR12458:SF8	CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DAPPU|EnsemblGenome=DAPPUDRAFT_188187|UniProtKB=E9GJ31	Guanine nucleotide binding protein, q polypeptide	ISS	8836152	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00034	Integrin signalling pathway	P00925	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00024	Glycolysis	P00674	Phosphoglucose isomerase	PANTR|Ensembl=ENSPTRG00000010816|UniProtKB=H2R306	Glucose-6-phosphate isomerase	RCA			PTHR11469:SF4	GLUCOSE-6-PHOSPHATE ISOMERASE
P00022	General transcription by RNA polymerase I	P00649	TAF-IC	ARATH|TAIR=AT5G15570|UniProtKB=Q9LF25	Bromodomain transcription factor	ISS			PTHR12321:SF53	BROMODOMAIN TRANSCRIPTION FACTOR
P00047	PDGF signaling pathway	P01160	IP3 receptor	MONDO|Ensembl=ENSMODG00000016591|UniProtKB=F6ZCW7	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00005	Angiogenesis	P00219	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00805	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01153	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	MACMU|Ensembl=ENSMMUG00000010184|UniProtKB=F6SR09	Uncharacterized protein	ISS	92317054	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P05734	Synaptic vesicle trafficking	P05779	Synaptobrevin	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	RCA	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04495	TSC1	MOUSE|MGI=MGI=1929183|UniProtKB=Q9EP53	Hamartin	ISS	12820960	PubMed	PTHR15154:SF2	HAMARTIN
P04397	p53 pathway by glucose deprivation	P04639	AMPK	RAT|RGD=620893|UniProtKB=Q09137	5'-AMP-activated protein kinase catalytic subunit alpha-2	ISS			PTHR24343:SF303	5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05977	G-Protein (s)	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	HUMAN|HGNC=16767|UniProtKB=Q8TCU5	Glutamate receptor ionotropic, NMDA 3A	ISS	14698601	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00018	EGF receptor signaling pathway	P00564	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12874273	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	HUMAN|HGNC=4595|UniProtKB=Q14832	Metabotropic glutamate receptor 3	ISS	20012997	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	15572354	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04371	5-Hydroxytryptamine biosynthesis	P04400	Aromatic L-amino acid decarboxylase	DROME|FlyBase=FBgn0000075|UniProtKB=P18486	Alpha-methyldopa hypersensitive protein	ISS	7567987	PubMed	PTHR11999:SF60	ALPHA-METHYLDOPA HYPERSENSITIVE PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	RAT|RGD=2343|UniProtKB=P08483	Muscarinic acetylcholine receptor M3	IDA	12915051	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00018	EGF receptor signaling pathway	P00539	14-3-3	PANTR|Ensembl=ENSPTRG00000011641|UniProtKB=H2QHF1	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	ISS	7603573	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P04398	p53 pathway feedback loops 2	P04651	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P05916	Opioid prodynorphin pathway	P05998	Kappa Receptor	RAT|RGD=69426|UniProtKB=P34975	Kappa-type opioid receptor	RCA	11259498	PubMed	PTHR24229:SF1	KAPPA-TYPE OPIOID RECEPTOR
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00052	TGF-beta signaling pathway	P01284	JNK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	TAS	12040174	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00049	Parkinson disease	P01234	GRK	RAT|RGD=2062|UniProtKB=P26817	Beta-adrenergic receptor kinase 1	IDA	8288567	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P00019	Endothelin signaling pathway	P00588	ET1-4	DANRE|ZFIN=ZDB-GENE-000920-1|UniProtKB=A5WW41	Uncharacterized protein	ISS	15117818	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P00053	T cell activation	P01298	NFkappaB	HUMAN|HGNC=7794|UniProtKB=P19838	Nuclear factor NF-kappa-B p105 subunit	IGI	12574369	PubMed	PTHR24169:SF9	NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	IC	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00036	Interleukin signaling pathway	P00981	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	TAS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	DAPPU|EnsemblGenome=DAPPUDRAFT_206575|UniProtKB=E9FUX0	Guanine nucleotide binding protein, beta subunit	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P02731	Biotin biosynthesis	P02858	8-Amino-7-oxononanoate synthase	STRCO|Gene=CAC01467|UniProtKB=Q9FCC4	8-amino-7-oxononanoate synthase	ISS			PTHR13693:SF77	8-AMINO-7-OXONONANOATE SYNTHASE
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00012	Cadherin signaling pathway	P00470	F-actin	TAKRU|Ensembl=ENSTRUG00000014318|UniProtKB=H2UI49	Uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P02772	Pyruvate metabolism	P03133	Pyruvate Dehydrogenase	STRCO|Gene=CAB99150|UniProtKB=Q9K3H0	Putative pyruvate dehydrogenase alpha subunit	ISS	12000953	PubMed	PTHR11516:SF2	SUBFAMILY NOT NAMED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04393	Ras Pathway	P04567	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04651	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DANRE|ZFIN=ZDB-GENE-040426-1178|UniProtKB=Q7SY24	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04393	Ras Pathway	P04552	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05918	p38 MAPK pathway	P06031	p38alpha	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	RCA	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00012	Cadherin signaling pathway	P00462	Casein kinase II	BOVIN|Gene=CSNK2A1|UniProtKB=P68399	Casein kinase II subunit alpha	ISS	10806215	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	TAKRU|Ensembl=ENSTRUG00000015938|UniProtKB=H2UUX5	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	IDA	94131270	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CANLF|Ensembl=ENSCAFG00000015708|UniProtKB=F2Z4N0	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00021	FGF signaling pathway	P00637	MKK4,7	XENTR|Xenbase=XB-GENE-487078|UniProtKB=Q4QQQ5	Mitogen-activated protein kinase kinase 7	RCA			PTHR24361:SF387	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DICPU|Gene=DICPUDRAFT_90232|UniProtKB=F1A175	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00059	p53 pathway	G04694	p110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00591	PLCbeta	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P06959	CCKR signaling map	P07090	MAPK8-10	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	RCA		PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00093	Tip60	HUMAN|HGNC=578|UniProtKB=Q02410	Amyloid beta A4 precursor protein-binding family A member 1	IC			PTHR12345:SF14	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 1
P00049	Parkinson disease	P01236	Casein kinase II	CIOIN|Ensembl=ENSCING00000009515|UniProtKB=Q8T3S5	Casein kinase 2 alpha subunit	IDA	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	IC	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00009	Axon guidance mediated by netrin	P00359	NFAT	MOUSE|MGI=MGI=1920431|UniProtKB=Q8K120	Nuclear factor of activated T-cells, cytoplasmic 4	IDA	9133421	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00012	Cadherin signaling pathway	P00477	GSK3beta	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00021	FGF signaling pathway	P00628	JNK1-3	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	HUMAN|HGNC=2453|UniProtKB=P49674	Casein kinase I isoform epsilon	ISS	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P02775	Salvage pyrimidine ribonucleotides	P03150	Uridine kinase	MACMU|Ensembl=ENSMMUG00000000565|UniProtKB=F6ZWL3	Uridine-cytidine kinase	ISS			PTHR10285:SF70	URIDINE-CYTIDINE KINASE 2
P00002	Alpha adrenergic receptor signaling pathway	P00078	Alpha1A/1B/1C	HUMAN|HGNC=282|UniProtKB=P18089	Alpha-2B adrenergic receptor	IC	6323229	PubMed	PTHR24248:SF26	ALPHA-2B ADRENERGIC RECEPTOR
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	BOVIN|Ensembl=ENSBTAG00000034854|UniProtKB=F1N246	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	DROME|FlyBase=FBgn0004087|UniProtKB=P17719	Dihydrofolate reductase	ISS			PTHR22778:SF16	DIHYDROFOLATE REDUCTASE
P00020	FAS signaling pathway	P00609	FAF1	PANTR|Ensembl=ENSPTRG00000000725|UniProtKB=H2QZI2	Fas (TNFRSF6) associated factor 1	ISS	8524870	PubMed	PTHR23322:SF52	FAS-ASSOCIATED FACTOR 1
P00010	B cell activation	P00398	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00049	Parkinson disease	P01208	Hsp70	XENTR|Xenbase=XB-GENE-485626|UniProtKB=A9JTJ5	Hsp70 protein	ISS	12150907	PubMed	PTHR19375:SF315	SUBFAMILY NOT NAMED
P00023	General transcription regulation	P00669	TFIIEalpha	MOUSE|MGI=MGI=1921447|UniProtKB=Q9D0D5	General transcription factor IIE subunit 1	ISS	189964	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000008751|UniProtKB=H2QC89	Uncharacterized protein	ISS	12507995	PubMed	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P02756	N-acetylglucosamine metabolism	P03041	Glucosamine-6-phosphate deaminase	BOVIN|Ensembl=ENSBTAG00000007865|UniProtKB=A4FV08	Glucosamine-6-phosphate isomerase 1	ISS			PTHR11280:SF8	GLUCOSAMINE-6-PHOSPHATE ISOMERASE 1
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	DAPPU|EnsemblGenome=DAPPUDRAFT_308488|UniProtKB=E9G252	Putative uncharacterized protein	ISS	11313498	PubMed	PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P00029	Huntington disease	P00786	ARF	DANRE|ZFIN=ZDB-GENE-030131-8007|UniProtKB=Q6P2U5	Uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00012	Cadherin signaling pathway	P00477	GSK3beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00021	FGF signaling pathway	P00641	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00006	Apoptosis signaling pathway	P00260	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00213	FGF	HUMAN|HGNC=3665|UniProtKB=P05230	Fibroblast growth factor 1	IDA	12057924	PubMed	PTHR11486:SF86	FIBROBLAST GROWTH FACTOR 1
P00018	EGF receptor signaling pathway	P00556	PLCgamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IGI	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	RCA	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	RCA	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00005	Angiogenesis	P00193	SOS-1	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IDA	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DICDI|dictyBase=DDB_G0280975|UniProtKB=Q23862	Rho-related protein racE	ISS			PTHR24072:SF143	RHO-RELATED PROTEIN RACE
P00034	Integrin signalling pathway	P00916	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=4506|UniProtKB=Q13585	Melatonin-related receptor	IDA			PTHR45535:SF1	MELATONIN-RELATED RECEPTOR
P00054	Toll receptor signaling pathway	P01375	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00010	B cell activation	P00386	Calcineurin	RAT|RGD=3382|UniProtKB=P63329	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	IDA	12015605	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95815|UniProtKB=P39087	Glutamate receptor ionotropic, kainate 2	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00007	Axon guidance mediated by semaphorins	P00340	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12676940	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00029	Huntington disease	P00800	PolyQ Htt	HUMAN|HGNC=4851|UniProtKB=P42858	Huntingtin	TAS	9462744	PubMed	PTHR10170:SF10	HUNTINGTIN
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CANLF|Ensembl=ENSCAFG00000028654|UniProtKB=J9P702	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00010	B cell activation	P00399	Ig-alpha	BOVIN|Ensembl=ENSBTAG00000001882|UniProtKB=P40293	B-cell antigen receptor complex-associated protein alpha chain	TAS	7963570	PubMed	PTHR14334:SF1	B-CELL ANTIGEN RECEPTOR COMPLEX-ASSOCIATED PROTEIN ALPHA CHAIN
P00006	Apoptosis signaling pathway	P00294	RAIDD	MACMU|Ensembl=ENSMMUG00000012670|UniProtKB=F7E329	Caspase and RIP adapter	ISS	8985253	PubMed	PTHR15034:SF5	DEATH DOMAIN-CONTAINING PROTEIN CRADD
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	BOVIN|Ensembl=ENSBTAG00000021988|UniProtKB=Q0VC91	Suppressor of cytokine signaling 4	ISS	10500304	PubMed	PTHR44282:SF2	SUPPRESSOR OF CYTOKINE SIGNALING 4
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	20010089	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	CAEEL|WormBase=WBGene00000204|UniProtKB=P58798	Probable actin-related protein 2/3 complex subunit 4	ISS	5031595	gi	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00034	Integrin signalling pathway	P00912	Arp2/3	CANLF|Ensembl=ENSCAFG00000015094|UniProtKB=F1PT97	Uncharacterized protein	ISS	12963527	gi	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	IC	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00060	Ubiquitin proteasome pathway	P01491	E2	CHICK|Ensembl=ENSGALG00000026906|UniProtKB=F1NKD9	Uncharacterized protein	ISS	20509589	PubMed	PTHR44178:SF1	FI14826P
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	CAEBR|Gene=CBG02247|UniProtKB=A8WS68	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00023	General transcription regulation	P00658	TBP-associated factors	MOUSE|MGI=MGI=1926879|UniProtKB=Q9EQH4	Transcription initiation factor TFIID subunit 8	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00052	TGF-beta signaling pathway	P01284	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00010	B cell activation	P00385	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Ensembl=ENSPTRG00000013825|UniProtKB=H2RAK4	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02763	Peptidoglycan biosynthesis	P03088	UDP-N-acetylmuramate dehydrogenase	THEMA|EnsemblGenome=TM_1714|UniProtKB=Q9X239	UDP-N-acetylenolpyruvoylglucosamine reductase	ISS			PTHR21071:SF4	UDP-N-ACETYLENOLPYRUVOYLGLUCOSAMINE REDUCTASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	IC	11319238	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00034	Integrin signalling pathway	P00951	Jnk	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00006	Apoptosis signaling pathway	P00315	RIP	MOUSE|MGI=MGI=108212|UniProtKB=Q60855	Receptor-interacting serine/threonine-protein kinase 1	ISS			PTHR44738:SF1	RECEPTOR-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	BOVIN|Ensembl=ENSBTAG00000018445|UniProtKB=E1BK87	Uncharacterized protein	ISS	14698601	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02913	Thymidylate synthase	ARATH|TAIR=AT2G16370|UniProtKB=Q05762	Bifunctional dihydrofolate reductase-thymidylate synthase 1	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P05915	Opioid proenkephalin pathway	P05989	leu-Enkephalin	DANRE|ZFIN=ZDB-GENE-030729-3|UniProtKB=F1QTD1	Uncharacterized protein (Fragment)	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	HUMAN|HGNC=6697|UniProtKB=O75197	Low-density lipoprotein receptor-related protein 5	IDA	11029006	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00010	B cell activation	P00371	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00549	EGF	PANTR|Ensembl=ENSPTRG00000016367|UniProtKB=H2QQ13	Uncharacterized protein	RCA			PTHR44717:SF1	PRO-EPIDERMAL GROWTH FACTOR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	HUMAN|HGNC=5291|UniProtKB=P28566	5-hydroxytryptamine receptor 1E	IDA			PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P00023	General transcription regulation	P00664	TFIIH complex	RAT|RGD=1305494|UniProtKB=Q561R7	General transcription factor IIH subunit 3	ISS			PTHR12831:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00034	Integrin signalling pathway	P00922	Collagen	MACMU|Ensembl=ENSMMUG00000011661|UniProtKB=F7HGW0	Uncharacterized protein	ISS			PTHR23220:SF5	INTEGRIN ALPHA-8
P00038	JAK/STAT signaling pathway	P01034	Jak	RAT|RGD=69056|UniProtKB=G3V9W2	Tyrosine-protein kinase	ISS	9637709	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00006	Apoptosis signaling pathway	P00302	ATF	MONDO|Ensembl=ENSMODG00000015970|UniProtKB=F7FD05	Uncharacterized protein	ISS	1354612	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00010	B cell activation	P00384	p38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00045	Notch signaling pathway	P01114	Ntm	HUMAN|HGNC=7881|UniProtKB=P46531	Neurogenic locus notch homolog protein 1	IGI	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00079	alpha7 nicotinic acetylcholine receptor	CAEEL|WormBase=WBGene00000055|UniProtKB=P48180	Acetylcholine receptor subunit alpha-type acr-16	IDA			PTHR18945:SF578	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-TYPE ACR-16
P00029	Huntington disease	G01535	PIG3	ORYSJ|EnsemblGenome=OS10G0561100|UniProtKB=Q336S6	Os10g0561100 protein	TAS			PTHR42975:SF1	QUINONE OXIDOREDUCTASE-RELATED
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	RCA	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01188	Gbetagamma	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CAEEL|WormBase=WBGene00000066|UniProtKB=P10986	Actin-4	IC	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	HUMAN|HGNC=7882|UniProtKB=Q04721	Neurogenic locus notch homolog protein 2	IDA	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00014	Cholesterol biosynthesis	P00499	Farnesyl-diphosphate farnesyltransferase	BOVIN|Ensembl=ENSBTAG00000012432|UniProtKB=Q6IE76	FDFT1 protein	ISS			PTHR11626:SF2	SQUALENE SYNTHASE
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	CHICK|Gene=AXIN1|UniProtKB=O42400	Axin-1	IEP	9554852	PubMed	PTHR10845:SF11	AXIN-1
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	91056091	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00049	Parkinson disease	P01242	Casein kinase I	DROME|FlyBase=FBgn0031441|UniProtKB=Q9VQE3	CG9962	IDA	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00005	Angiogenesis	P00219	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00048	PI3 kinase pathway	P01192	p110	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00053	T cell activation	P01332	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05972	PKA	DROME|FlyBase=FBgn0000489|UniProtKB=P16912	Protein kinase DC2	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	STRPU|EnsemblGenome=SPU_018419|UniProtKB=W4YRI6	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00516	Ena/VASP	MOUSE|MGI=MGI=1194884|UniProtKB=P70429	Ena/VASP-like protein	ISS			PTHR11202:SF4	ENA/VASP-LIKE PROTEIN
P00049	Parkinson disease	P01219	SAPK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	NAS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P06664	Gonadotropin-releasing hormone receptor pathway	P06794	MAP2K1/2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	RCA	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00057	Wnt signaling pathway	P01428	Frizzled	RAT|RGD=1560525|UniProtKB=Q498S8	Frizzled-8	ISS	8717036	PubMed	PTHR11309:SF90	FRIZZLED-8
P00048	PI3 kinase pathway	P01177	P110ACT	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	IGI	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P00038	JAK/STAT signaling pathway	P01027	STAT	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	14984365	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01192	p110	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05957	K+ channel	RAT|RGD=621451|UniProtKB=Q9ES08	Potassium channel subfamily K member 9	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P05731	GABA-B receptor II signaling	P05754	Ggamma	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00029	Huntington disease	P00790	beta-Tubulin	PHYIT|EnsemblGenome=PITG_00156|UniProtKB=D0MT13	Beta-tubulin	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04397	p53 pathway by glucose deprivation	P04641	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	G01579	PTEN	HUMAN|HGNC=12023|UniProtKB=P56180	Putative tyrosine-protein phosphatase TPTE	IGI			PTHR12305:SF32	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE TPTE2-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	MOUSE|MGI=MGI=99418|UniProtKB=Q9Z329	Inositol 1,4,5-trisphosphate receptor type 2	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00030	Hypoxia response via HIF activation	P00819	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05734	Synaptic vesicle trafficking	P05780	Rab3A	MACMU|Ensembl=ENSMMUG00000005027|UniProtKB=F7ASU4	Ras-related protein Rab-3A	ISS	9194562	PubMed	PTHR24073:SF532	RAS-RELATED PROTEIN RAB-3A
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Ensembl=ENSBTAG00000014674|UniProtKB=P41985	Muscarinic acetylcholine receptor M2	ISS	10069496	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P04371	5-Hydroxytryptamine biosynthesis	P04400	Aromatic L-amino acid decarboxylase	MACMU|Ensembl=ENSMMUG00000019991|UniProtKB=F7FNW0	Aromatic-L-amino-acid decarboxylase	ISS	90339966	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00022	General transcription by RNA polymerase I	P00657	TBP	CHICK|Ensembl=ENSGALG00000013981|UniProtKB=Q9YGV8	TATA box-binding protein-like protein 1	ISS	10454611	PubMed	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00018	EGF receptor signaling pathway	P00546	GAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	14707121	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00012	Cadherin signaling pathway	P00470	F-actin	DANRE|ZFIN=ZDB-GENE-000329-3|UniProtKB=Q7ZVF9	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00047	PDGF signaling pathway	P01162	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00034	Integrin signalling pathway	P00922	Collagen	MOUSE|MGI=MGI=2444259|UniProtKB=Q8C6K9	Collagen alpha-6(VI) chain	IDA	10778855	PubMed	PTHR44105:SF3	COLLAGEN ALPHA-6 VI  CHAIN
P00019	Endothelin signaling pathway	P00591	PLCbeta	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	9860142	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00056	VEGF signaling pathway	P01412	HSP27	MOUSE|MGI=MGI=1916503|UniProtKB=Q99PR8	Heat shock protein beta-2	ISS			PTHR11527:SF163	HEAT SHOCK PROTEIN BETA-2
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PANTR|Ensembl=ENSPTRG00000002086|UniProtKB=H2Q1A9	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	2842690	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00018	EGF receptor signaling pathway	P00548	RKIP	ANOGA|EnsemblGenome=AGAP008909|UniProtKB=Q7PWN1	AGAP008909-PA	ISS			PTHR11362:SF28	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000000985|UniProtKB=F6VRS9	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00007	Axon guidance mediated by semaphorins	P00339	CRMP	RAT|RGD=2407|UniProtKB=Q62950	Dihydropyrimidinase-related protein 1	IDA	96424532	PubMed	PTHR11647:SF54	DIHYDROPYRIMIDINASE-RELATED PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	1718748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00474	Wnt	XENTR|Xenbase=XB-GENE-479567|UniProtKB=A4ZGP0	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	PANTR|Ensembl=ENSPTRG00000008872|UniProtKB=H2QCF4	Aldehyde dehydrogenase	ISS	14724059	PubMed	PTHR43570:SF9	FATTY ALDEHYDE DEHYDROGENASE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	DICDI|dictyBase=DDB_G0279911|UniProtKB=P34093	Nucleoside diphosphate kinase, mitochondrial	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	HUMAN|HGNC=17167|UniProtKB=Q9BQS2	Synaptotagmin-15	RCA			PTHR10024:SF234	SYNAPTOTAGMIN-15
P00029	Huntington disease	P00811	Arp2/3 complex	HUMAN|HGNC=23366|UniProtKB=Q9BPX5	Actin-related protein 2/3 complex subunit 5-like protein	TAS	12932731	PubMed	PTHR12644:SF2	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5-LIKE PROTEIN
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	BOVIN|Ensembl=ENSBTAG00000037726|UniProtKB=P10895	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	15611108	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00048	PI3 kinase pathway	P01198	FOXO	BOVIN|Ensembl=ENSBTAG00000011234|UniProtKB=F1N4K5	Uncharacterized protein	ISS	14775847	gi	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00029	Huntington disease	P00807	Actin	CHICK|Gene=ACTG2|UniProtKB=P63270	Actin, gamma-enteric smooth muscle	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	P01464	Pygo	DROME|FlyBase=FBgn0043900|UniProtKB=Q9V9W8	Protein pygopus	ISS	11955446	PubMed	PTHR23194:SF16	PROTEIN BCL9 HOMOLOG-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00519	ROCK	HUMAN|HGNC=10251|UniProtKB=Q13464	Rho-associated protein kinase 1	ISS	10779382	PubMed	PTHR22988:SF33	RHO-ASSOCIATED PROTEIN KINASE 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	CANLF|Ensembl=ENSCAFG00000018359|UniProtKB=E2QZ78	Uncharacterized protein	TAS	11389954	PubMed	PTHR23036:SF89	INTERLEUKIN-13 RECEPTOR SUBUNIT ALPHA-1
P00046	Oxidative stress response	P01137	MNK1/2	RAT|RGD=1305728|UniProtKB=Q5U2N4	MAP kinase-interacting serine/threonine-protein kinase 2	ISS	9155017	PubMed	PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P04393	Ras Pathway	P04557	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	IDA	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P06959	CCKR signaling map	P07123	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	RCA	19063708	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00019	Endothelin signaling pathway	P00589	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	IGI	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00566	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	ARATH|TAIR=AT5G07880|UniProtKB=Q9SD96	SNAP25 homologous protein SNAP29	ISS			PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=2136748|UniProtKB=Q91Y06	Protein Pcdhb13	IDA	8120095	PubMed	PTHR24028:SF104	PROTOCADHERIN BETA-6
P04372	5-Hydroxytryptamine degredation	P04401	Monoamine Oxidase	PANTR|Ensembl=ENSPTRG00000021816|UniProtKB=H2QYH5	Amine oxidase [flavin-containing]	ISS	8602220	PubMed	PTHR43563:SF3	AMINE OXIDASE  FLAVIN-CONTAINING  A
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P06664	Gonadotropin-releasing hormone receptor pathway	P06758	DRD2	MOUSE|MGI=MGI=94924|UniProtKB=P61168	D(2) dopamine receptor	RCA	1319557	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	BRAFL|Gene=BRAFLDRAFT_121298|UniProtKB=C3Z299	Putative uncharacterized protein	ISS			PTHR42884:SF13	NEUROENDOCRINE CONVERTASE 2
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=2322|UniProtKB=P55280	Cadherin-6	IDA	8120095	PubMed	PTHR24027:SF322	CADHERIN-6
P06959	CCKR signaling map	P07197	Gbeta/gamma	HUMAN|HGNC=4404|UniProtKB=P59768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	RCA	12853286	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P05915	Opioid proenkephalin pathway	P05994	G-protein	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	IDA	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	RCA	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00807	Actin	IXOSC|EnsemblGenome=ISCW024111|UniProtKB=B7PBG2	Actin, putative (Fragment)	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00021	FGF signaling pathway	P00629	PP2A	PANTR|Ensembl=ENSPTRG00000001958|UniProtKB=H2Q137	Uncharacterized protein	ISS	12110603	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DAPPU|EnsemblGenome=DAPPUDRAFT_206575|UniProtKB=E9FUX0	Guanine nucleotide binding protein, beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P05916	Opioid prodynorphin pathway	P06002	G-protein	ARATH|TAIR=AT4G34460|UniProtKB=P49177	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF48	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00024	Glycolysis	P00679	Aldolase	MOUSE|MGI=MGI=1931052|UniProtKB=A6ZI47	Fructose-bisphosphate aldolase	ISS	3391172	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00029	Huntington disease	P00807	Actin	TAKRU|Ensembl=ENSTRUG00000005447|UniProtKB=P68142	Actin, cytoplasmic 1	IDA	10974003	PubMed	PTHR11937:SF354	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00561	STAT	CHICK|Ensembl=ENSGALG00000003267|UniProtKB=Q6DV79	Signal transducer and activator of transcription 3	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MACMU|Ensembl=ENSMMUG00000016675|UniProtKB=F6VTB5	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00047	PDGF signaling pathway	P01165	SRF	HUMAN|HGNC=11291|UniProtKB=P11831	Serum response factor	ISS	8660892	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00029	Huntington disease	P00810	GAPDH	MONDO|Ensembl=ENSMODG00000018066|UniProtKB=F7G487	Uncharacterized protein	ISS	8612237	PubMed	PTHR10836:SF51	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE
P00006	Apoptosis signaling pathway	P00260	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00251	cPLA2	MACMU|Ensembl=ENSMMUG00000021423|UniProtKB=F7EEZ1	Phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00539	14-3-3	BOVIN|Ensembl=ENSBTAG00000002108|UniProtKB=Q3SZI4	14-3-3 protein theta	ISS	7603573	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P00034	Integrin signalling pathway	P00922	Collagen	RAT|RGD=1307029|UniProtKB=D3ZNT5	Procollagen, type IX, alpha 2 (Predicted)	ISS	10778855	PubMed	PTHR44706:SF1	COLLAGEN ALPHA-2 IX  CHAIN
P00021	FGF signaling pathway	P00638	PLCgamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00048	PI3 kinase pathway	P01177	P110ACT	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	BOVIN|Ensembl=ENSBTAG00000014050|UniProtKB=F1MF30	Uncharacterized protein	ISS	15155845	PubMed	PTHR18945:SF75	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-3
P00006	Apoptosis signaling pathway	P00307	ELF2alpha	PYRAE|EnsemblGenome=PAE3032|UniProtKB=Q8ZTY5	Translation initiation factor 2 subunit alpha	ISS			PTHR10602:SF0	EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	TAKRU|Ensembl=ENSTRUG00000008289|UniProtKB=H2T7U8	Uncharacterized protein	ISS	12928366	PubMed	PTHR24072:SF129	CDC42L PROTEIN
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=13733|UniProtKB=Q9H251	Cadherin-23	IDA	8120095	PubMed	PTHR43956:SF3	CADHERIN-23
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	HUMAN|HGNC=4588|UniProtKB=O15399	Glutamate receptor ionotropic, NMDA 2D	IC	11554549	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00045	Notch signaling pathway	P01110	Presenilin	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	ISS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	MOUSE|MGI=MGI=1928679|UniProtKB=Q9EQF5	Dihydropyrimidinase	ISS	8679696	PubMed	PTHR11647:SF50	DIHYDROPYRIMIDINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000019361|UniProtKB=H2QUV3	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00046	Oxidative stress response	P01122	TRX	MOUSE|MGI=MGI=98874|UniProtKB=P10639	Thioredoxin	TAS	12115731	PubMed	PTHR10438:SF18	THIOREDOXIN
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	TAKRU|Ensembl=ENSTRUG00000009259|UniProtKB=H2TF39	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00024	Glycolysis	P00673	Triosephosphate isomerase	ARATH|TAIR=AT1G79550|UniProtKB=Q9SAJ4	Phosphoglycerate kinase	ISS			PTHR11406:SF0	PHOSPHOGLYCERATE KINASE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	SCHPO|PomBase=SPAC806.07|UniProtKB=P49740	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CAEEL|WormBase=WBGene00002039|UniProtKB=P91443	Unconventional myosin heavy chain 6	IC			PTHR13140:SF703	MYOSIN 28B1, ISOFORM B-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ANOGA|EnsemblGenome=AGAP001506|UniProtKB=Q7PXP3	AGAP001506-PA	IC	11313908	PubMed	PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000000985|UniProtKB=F6VRS9	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00048	PI3 kinase pathway	P01199	Galpha	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Ensembl=ENSBTAG00000013047|UniProtKB=E1BLE8	Uncharacterized protein	ISS	11431030	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00053	T cell activation	P01332	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02747	Histidine biosynthesis	P02993	Phosphoribosylformimino-5-amino-1-phosphoribosyl-4 imadazol carboxamide isomerase	LEPIN|EnsemblGenome=LA_0126|UniProtKB=Q8F9R5	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase	ISS			PTHR43090:SF2	1- 5-PHOSPHORIBOSYL -5-  5-PHOSPHORIBOSYLAMINO METHYLIDENEAMINO  IMIDAZOLE-4-CARBOXAMIDE ISOMERASE
P00036	Interleukin signaling pathway	P00983	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00054	Toll receptor signaling pathway	P01375	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	ANOGA|EnsemblGenome=AGAP005773|UniProtKB=A0NEH6	AGAP005773-PA	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00029	Huntington disease	P00804	Synaptojanin	HUMAN|HGNC=11503|UniProtKB=O43426	Synaptojanin-1	RCA			PTHR11200:SF158	SYNAPTOJANIN-1
P00049	Parkinson disease	P01242	Casein kinase I	BOVIN|Ensembl=ENSBTAG00000039794|UniProtKB=P35507	Casein kinase I isoform beta	IDA	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000004389|UniProtKB=F7FMS7	Cadherin-14	ISS	8120095	PubMed	PTHR24027:SF106	CADHERIN-18
P02785	Valine biosynthesis	P03215	Branched chain amino acid aminotransferase	BOVIN|Ensembl=ENSBTAG00000009172|UniProtKB=Q5EA40	Branched-chain-amino-acid aminotransferase, mitochondrial	ISS			PTHR11825:SF39	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, MITOCHONDRIAL
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	BOVIN|Ensembl=ENSBTAG00000037726|UniProtKB=P10895	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	7822322	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	IDA	20451058	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	RAT|RGD=1311191|UniProtKB=D3ZN51	Protein Itga9	ISS	10209034	PubMed	PTHR23220:SF69	INTEGRIN ALPHA-9
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	RAT|RGD=1563860|UniProtKB=D3Z8E0	Ribosomal protein S6 kinase	ISS	10558991	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P02738	De novo purine biosynthesis	P02900	AICAR transformylase	PANTR|Ensembl=ENSPTRG00000012891|UniProtKB=H2R0X5	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P00006	Apoptosis signaling pathway	P00297	NFkappaB	BOVIN|Ensembl=ENSBTAG00000013895|UniProtKB=A1XG22	NF-kappaB transcription factor p65 subunit	ISS	10049353	PubMed	PTHR24169:SF1	TRANSCRIPTION FACTOR P65
P00005	Angiogenesis	P00252	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	12748278	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00775	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DICDI|dictyBase=DDB_G0268744|UniProtKB=Q55EU6	Putative actin-23	IC	10974003	PubMed	PTHR11937:SF154	ACTIN-17-RELATED
P00059	p53 pathway	P04623	CBP	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	IDA	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CAEEL|WormBase=WBGene00000248|UniProtKB=Q18817	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF120	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	CANLF|Ensembl=ENSCAFG00000015043|UniProtKB=F1PVS9	Uncharacterized protein	TAS	12834808	PubMed	PTHR10201:SF165	COLLAGENASE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	8787761	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00045	Notch signaling pathway	P01118	Numb	HUMAN|HGNC=8060|UniProtKB=P49757	Protein numb homolog	IGI	10468633	PubMed	PTHR11232:SF33	PROTEIN NUMB HOMOLOG
P00010	B cell activation	P00371	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000016815|UniProtKB=F7C9S6	Uncharacterized protein	ISS	12562507	PubMed	PTHR24229:SF52	SOMATOSTATIN RECEPTOR TYPE 4
P00047	PDGF signaling pathway	P01153	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00057	Wnt signaling pathway	P01438	PP2A	PANTR|Ensembl=ENSPTRG00000006426|UniProtKB=H2Q8F8	Protein phosphatase 2, regulatory subunit B', epsilon isoform	ISS	11007767	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00053	T cell activation	P01332	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IDA	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00007	Axon guidance mediated by semaphorins	P00341	Rho	MONDO|Ensembl=ENSMODG00000012981|UniProtKB=F7CS91	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00034	Integrin signalling pathway	P00951	Jnk	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00017	DNA replication	P00529	RFC	MOUSE|MGI=MGI=1919401|UniProtKB=Q9D0F6	Replication factor C subunit 5	RCA			PTHR11669:SF9	REPLICATION FACTOR C SUBUNIT 5
P00048	PI3 kinase pathway	P01188	Gbetagamma	XENTR|Xenbase=XB-GENE-977853|UniProtKB=F7EBE7	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04397	p53 pathway by glucose deprivation	P04641	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00020	FAS signaling pathway	P00615	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	15528206	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	ORNAN|Ensembl=ENSOANG00000000985|UniProtKB=F6XK44	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF147	REGULATOR OF G-PROTEIN SIGNALING 8
P04393	Ras Pathway	P04556	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P02738	De novo purine biosynthesis	P02903	Phosphoribosylglycinamide  formyltransferase	FUSNN|EnsemblGenome=FN0985|UniProtKB=Q8REV4	Phosphoribosylglycinamide formyltransferase	ISS			PTHR43369:SF2	PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P05731	GABA-B receptor II signaling	P05752	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00054	Toll receptor signaling pathway	P01379	Tollip	RAT|RGD=1304676|UniProtKB=A2RUW1	Toll-interacting protein	ISS			PTHR16461:SF5	TOLL-INTERACTING PROTEIN
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2847|UniProtKB=P28565	5-hydroxytryptamine receptor 1D	IDA	12441358	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	CAEEL|WormBase=WBGene00004769|UniProtKB=P52166	Presenilin sel-12	IDA	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000035697|UniProtKB=Q28024	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00048	PI3 kinase pathway	P01192	p110	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01438	PP2A	MONDO|Ensembl=ENSMODG00000014177|UniProtKB=F6U7A6	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	RAT|RGD=619965|UniProtKB=P26769	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00021	FGF signaling pathway	P00646	RasGAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	IPI	2574500	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00036	Interleukin signaling pathway	P00965	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00059	p53 pathway	P01486	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00314	MKK3	MONDO|Ensembl=ENSMODG00000001404|UniProtKB=F7BD74	Uncharacterized protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	GLOVI|Gene=BAC88993|UniProtKB=Q7NLR9	Glutamine synthetase	ISS			PTHR43407:SF1	LENGSIN
P00012	Cadherin signaling pathway	P00470	F-actin	DANRE|ZFIN=ZDB-GENE-000329-3|UniProtKB=Q7ZVF9	Actin, cytoplasmic 2	ISS	3487386	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00029	Huntington disease	P00807	Actin	MONBE|Gene=37852|UniProtKB=A9V489	Predicted protein	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00010	B cell activation	P00372	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	11384839	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000011231|UniProtKB=F6WXV4	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00052	TGF-beta signaling pathway	P01275	P38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00052	TGF-beta signaling pathway	P01284	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00005	Angiogenesis	P00182	p38MAPK	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04395	Vasopressin synthesis	P04589	Signal Peptidase	CAEEL|WormBase=WBGene00012550|UniProtKB=Q9XWW1	Probable signal peptidase complex subunit 2	IC	7788527	PubMed	PTHR13085:SF0	SIGNAL PEPTIDASE COMPLEX SUBUNIT 2
P02738	De novo purine biosynthesis	P02909	GDP reductase	BACSU|EnsemblGenome=BSU20040|UniProtKB=O30601	SPBc2 prophage-derived ribonucleoside-diphosphate reductase subunit beta	ISS			PTHR23409:SF32	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT BETA
P00010	B cell activation	P00401	jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00048	PI3 kinase pathway	P01192	p110	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	CAEEL|WormBase=WBGene00001985|UniProtKB=O02100	Presenilin hop-1	TAS	12834808	PubMed	PTHR10202:SF14	PRESENILIN HOP-1
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	CAEEL|WormBase=WBGene00004769|UniProtKB=P52166	Presenilin sel-12	TAS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00057	Wnt signaling pathway	P01446	Calcineurin	MOUSE|MGI=MGI=107164|UniProtKB=P63328	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	ISS	12015605	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00379	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05731	GABA-B receptor II signaling	P05760	AC	RAT|RGD=2036|UniProtKB=P40146	Adenylate cyclase type 8	RCA	8163524	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00005	Angiogenesis	P00189	Fzd	CHICK|Gene=FZD1|UniProtKB=O57328	Frizzled-1	ISS	11212302	PubMed	PTHR11309:SF81	FRIZZLED-1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CAEEL|WormBase=WBGene00000200|UniProtKB=P53489	Actin-related protein 2	IDA	11889126	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=109355|UniProtKB=O35526	Syntaxin-1A	ISS	1321498	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	BOVIN|Ensembl=ENSBTAG00000008429|UniProtKB=F1ML31	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF4	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4
P00010	B cell activation	P00391	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00018	EGF receptor signaling pathway	P00548	RKIP	ORYSJ|EnsemblGenome=OS12G0152000|UniProtKB=Q2QXL9	CENTRORADIALIS, putative, expressed	ISS			PTHR11362:SF13	PROTEIN TERMINAL FLOWER 1
P00049	Parkinson disease	P01232	CASK	MOUSE|MGI=MGI=1309489|UniProtKB=O70589	Peripheral plasma membrane protein CASK	IPI	11679592	PubMed	PTHR23122:SF40	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P00029	Huntington disease	P00807	Actin	CRYNJ|EnsemblGenome=CNA04650|UniProtKB=Q5KP06	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04393	Ras Pathway	P04548	ATF2	MONDO|Ensembl=ENSMODG00000009514|UniProtKB=F7EVK3	Uncharacterized protein	ISS	9819389	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00056	VEGF signaling pathway	P01403	VEGFR-2	CANLF|Ensembl=ENSCAFG00000002079|UniProtKB=Q2XPT7	Uncharacterized protein	ISS	11221852	PubMed	PTHR24416:SF45	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00059	p53 pathway	G04696	Siah	HUMAN|HGNC=10857|UniProtKB=Q8IUQ4	E3 ubiquitin-protein ligase SIAH1	ISS	11389839	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MACMU|Ensembl=ENSMMUG00000010184|UniProtKB=F6SR09	Uncharacterized protein	ISS	14614461	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00025	Hedgehog signaling pathway	P00691	CBP	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04393	Ras Pathway	P04553	PAK	HUMAN|HGNC=8590|UniProtKB=Q13153	Serine/threonine-protein kinase PAK 1	IDA	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00006	Apoptosis signaling pathway	P00268	GCK	PANTR|Ensembl=ENSPTRG00000006332|UniProtKB=H2Q8A0	Mitogen-activated protein kinase kinase kinase kinase	ISS			PTHR24361:SF324	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 5
P00047	PDGF signaling pathway	P01154	Ras	HUMAN|HGNC=15980|UniProtKB=Q96A58	Ras-related and estrogen-regulated growth inhibitor	ISS			PTHR24070:SF373	RAS-RELATED AND ESTROGEN-REGULATED GROWTH INHIBITOR
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	BRAFL|Gene=BRAFLDRAFT_215305|UniProtKB=C3YPV2	Putative uncharacterized protein (Fragment)	ISS	9230079	PubMed	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00019	Endothelin signaling pathway	P00590	IP3 R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	IGI	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	IXOSC|EnsemblGenome=ISCW003614|UniProtKB=B7PHY7	Cdc42 protein, putative	ISS	9658176	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00048	PI3 kinase pathway	P01177	P110ACT	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02746	Heme biosynthesis	P02975	Uroporphyrinogen decarboxylase	STRCO|EnsemblGenome=CAA19243|UniProtKB=O69861	Uroporphyrinogen decarboxylase	ISS			PTHR21091:SF2	UROPORPHYRINOGEN DECARBOXYLASE
P00045	Notch signaling pathway	P01118	Numb	CANLF|Ensembl=ENSCAFG00000016834|UniProtKB=F6UX21	Uncharacterized protein	ISS	8755477	PubMed	PTHR11232:SF33	PROTEIN NUMB HOMOLOG
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DICPU|Gene=DICPUDRAFT_93216|UniProtKB=F1A421	Guanine nucleotide-binding protein subunit beta	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00045	Notch signaling pathway	P01108	Nicastrin	CAEEL|WormBase=WBGene00000148|UniProtKB=Q23316	Nicastrin	TAS	16096062	PubMed	PTHR21092:SF0	NICASTRIN
P04393	Ras Pathway	P04546	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IDA	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	LEIMA|EnsemblGenome=LmjF.35.4010|UniProtKB=Q9GNR4	Protein kinase A catalytic subunit isoform 1	IC	10553940	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00057	Wnt signaling pathway	P01444	Wnt	MONDO|Ensembl=ENSMODG00000012401|UniProtKB=F6PMQ6	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00056	VEGF signaling pathway	P01407	Erk	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	ARATH|TAIR=AT1G22020|UniProtKB=Q9LM59	Serine hydroxymethyltransferase 6	ISS			PTHR11680:SF7	SERINE HYDROXYMETHYLTRANSFERASE 6-RELATED
P00052	TGF-beta signaling pathway	P01275	P38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00018	EGF receptor signaling pathway	P00551	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IGI	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04666	cyclin A	MOUSE|MGI=MGI=108042|UniProtKB=Q61456	Cyclin-A1	RCA			PTHR10177:SF254	CYCLIN-A1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	STRPU|EnsemblGenome=SPU_026078|UniProtKB=W4ZD41	Uncharacterized protein	IDA	14684598	PubMed	PTHR11937:SF277	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IDA	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	MONBE|Gene=11217|UniProtKB=A9V8J8	Predicted protein	ISS			PTHR23050:SF245	AT16150P-RELATED
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CAEBR|Gene=CBG02401|UniProtKB=A8WUE7	Protein CBR-NMR-1	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	STRPU|EnsemblGenome=SPU_016007|UniProtKB=W4YJP3	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00029	Huntington disease	P00786	ARF	TRYB2|Gene=Tb09.211.4460|UniProtKB=Q38D65	ADP-ribosylation factor, putative	ISS	12932731	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	ISS	1650351	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00037	Ionotropic glutamate receptor pathway	P01006	NR2C	HUMAN|HGNC=4587|UniProtKB=Q14957	Glutamate receptor ionotropic, NMDA 2C	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	PANTR|Ensembl=ENSPTRG00000009200|UniProtKB=H2QD20	Signal transducer and activator of transcription	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00018	EGF receptor signaling pathway	P00561	STAT	CANLF|Ensembl=ENSCAFG00000015346|UniProtKB=E2RE22	Signal transducer and activator of transcription	ISS	95188889	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00005	Angiogenesis	P00219	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	ARATH|TAIR=AT1G66200|UniProtKB=Q8LCE1	Glutamine synthetase cytosolic isozyme 1-2	ISS			PTHR20852:SF58	GLUTAMINE SYNTHETASE CYTOSOLIC ISOZYME 1-2
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IGI	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	14744428	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00034	Integrin signalling pathway	P00907	ERK	MONDO|Ensembl=ENSMODG00000004896|UniProtKB=F7C2C6	Uncharacterized protein (Fragment)	ISS	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00019	Endothelin signaling pathway	P00586	Gq	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	8457205	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P05915	Opioid proenkephalin pathway	P05994	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	XENTR|Xenbase=XB-GENE-480347|UniProtKB=Q6P640	Actin, alpha cardiac muscle 1	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	NEUCR|EnsemblGenome=EFNCRG00000000159|UniProtKB=F5HH30	Guanine nucleotide-binding protein beta subunit	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00021	FGF signaling pathway	P00644	p38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00006	Apoptosis signaling pathway	P00314	MKK3	CHICK|Ensembl=ENSGALG00000004735|UniProtKB=F1NHE1	Uncharacterized protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00050	Plasminogen activating cascade	P01253	Fibrin	CHICK|Gene=FGA|UniProtKB=P14448	Fibrinogen alpha chain	ISS	1706798	gi	PTHR19143:SF232	FIBRINOGEN ALPHA CHAIN
P00038	JAK/STAT signaling pathway	P01027	STAT	DANRE|ZFIN=ZDB-GENE-980526-499|UniProtKB=Q6P943	Signal transducer and activator of transcription	ISS	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	LEIMA|EnsemblGenome=LmjF.35.3960|UniProtKB=E9AFM1	Protein kinase A catalytic subunit isoform 2	IC	10553940	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00009	Axon guidance mediated by netrin	P00363	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00005	Angiogenesis	P00254	GTPase	XENTR|Xenbase=XB-GENE-489222|UniProtKB=Q28GJ8	Ras homolog gene family, member A	ISS	10556059	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00005	Angiogenesis	P00190	RasGAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	7806540	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00048	PI3 kinase pathway	P01192	p110	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	PANTR|Ensembl=ENSPTRG00000020202|UniProtKB=H2QW34	Uncharacterized protein	ISS	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00990	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	CANLF|Ensembl=ENSCAFG00000009967|UniProtKB=F1PGZ2	Muscarinic acetylcholine receptor	ISS	12915051	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P02781	Threonine biosynthesis	P03190	Threonine synthase	CRYNJ|EnsemblGenome=CNB01150|UniProtKB=Q5KMM7	Threonine synthase, putative	ISS	15077836	gi	PTHR42690:SF1	THREONINE SYNTHASE-LIKE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Ensembl=ENSBTAG00000016187|UniProtKB=F1N213	Uncharacterized protein	ISS	9407094	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P02731	Biotin biosynthesis	P02859	Dethiobiotin synthase	GLOVI|EnsemblGenome=BAC91450|UniProtKB=Q7NFL5	ATP-dependent dethiobiotin synthetase BioD	ISS			PTHR43210:SF2	DETHIOBIOTIN SYNTHETASE
P00009	Axon guidance mediated by netrin	P00356	UNC-5	CAEBR|Gene=CBG19929|UniProtKB=A8XWR5	Protein CBR-UNC-5	ISS	1384987	PubMed	PTHR12582:SF45	NETRIN RECEPTOR UNC-5
P00029	Huntington disease	P00790	beta-Tubulin	MOUSE|MGI=MGI=107848|UniProtKB=Q9D6F9	Tubulin beta-4A chain	TAS	9454836	PubMed	PTHR11588:SF253	TUBULIN BETA-4A CHAIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	18021322	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00020	FAS signaling pathway	P00617	FasL	MACMU|Gene=FASLG|UniProtKB=P63307	Tumor necrosis factor ligand superfamily member 6	ISS	7528780	PubMed	PTHR11471:SF33	TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 6
P02726	Aminobutyrate degradation	P02825	4-aminobutyrate aminotransferase	EMENI|EnsemblGenome=CADANIAG00008938|UniProtKB=P14010	4-aminobutyrate aminotransferase	ISS	8133261	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00019	Endothelin signaling pathway	P00587	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00508	Cofilin	RAT|RGD=1306982|UniProtKB=M0RC65	Cofilin 2, muscle (Predicted), isoform CRA_b	ISS			PTHR11913:SF15	COFILIN-2
P00010	B cell activation	P00373	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	DROME|FlyBase=FBgn0000490|UniProtKB=P07713	Protein decapentaplegic	TAS	9759503	PubMed	PTHR11848:SF234	PROTEIN DECAPENTAPLEGIC
P00038	JAK/STAT signaling pathway	P01027	STAT	MOUSE|MGI=MGI=103038|UniProtKB=P42227	Signal transducer and activator of transcription 3	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00034	Integrin signalling pathway	P00916	Ras	YEAST|SGD=S000005042|UniProtKB=P01120	Ras-like protein 2	IPI	7997267	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MACMU|Ensembl=ENSMMUG00000012933|UniProtKB=F6RKD2	Uncharacterized protein	ISS			PTHR13140:SF341	UNCONVENTIONAL MYOSIN-IE
P00047	PDGF signaling pathway	P01154	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	IC	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MONDO|Ensembl=ENSMODG00000013810|UniProtKB=F6SXE3	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P00034	Integrin signalling pathway	P00924	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	PANTR|Ensembl=ENSPTRG00000001749|UniProtKB=H2Q0Q4	Uncharacterized protein	ISS	11976940	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00470	F-actin	DANRE|ZFIN=ZDB-GENE-050417-267|UniProtKB=F1QUN8	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF263	ACTIN
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00018	EGF receptor signaling pathway	P00562	p38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IGI	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00005	Angiogenesis	P00182	p38MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	CANLF|Ensembl=ENSCAFG00000006946|UniProtKB=E2RHZ1	Uncharacterized protein	ISS	10617630	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	XENTR|Xenbase=XB-GENE-482228|UniProtKB=F6RYL1	Uncharacterized protein	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P06587	Nicotine pharmacodynamics pathway	P06595	CHRNA3	BOVIN|Gene=CHRNA3|UniProtKB=Q07263	Neuronal acetylcholine receptor subunit alpha-3	ISS	85270494	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P00005	Angiogenesis	P00193	SOS-1	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00056	VEGF signaling pathway	P01425	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	87218499	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00057	Wnt signaling pathway	P01440	Cadherin	PANTR|Ensembl=ENSPTRG00000016444|UniProtKB=H2QQ62	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF0	PROTOCADHERIN-10
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	RAT|RGD=2626|UniProtKB=P12841	Proto-oncogene c-Fos	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00034	Integrin signalling pathway	P00913	Csk	XENTR|Xenbase=XB-GENE-5771921|UniProtKB=F6UTP2	Tyrosine-protein kinase	ISS	7687537	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00037	Ionotropic glutamate receptor pathway	P01005	NR2D	MOUSE|MGI=MGI=95823|UniProtKB=Q03391	Glutamate receptor ionotropic, NMDA 2D	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00036	Interleukin signaling pathway	P00982	p27KIP1	MOUSE|MGI=MGI=104565|UniProtKB=P46414	Cyclin-dependent kinase inhibitor 1B	ISS			PTHR10265:SF9	CYCLIN-DEPENDENT KINASE INHIBITOR 1B
P05731	GABA-B receptor II signaling	P05754	Ggamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04563	Ets	HUMAN|HGNC=3488|UniProtKB=P14921	Protein C-ets-1	IDA	15298723	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00029	Huntington disease	P00776	c-Jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	XENTR|Xenbase=XB-GENE-6053489|UniProtKB=F6S8L5	Tyrosine-protein kinase	ISS	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P04393	Ras Pathway	P04557	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	IDA	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	IC	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00034	Integrin signalling pathway	P00944	Actin	DANRE|ZFIN=ZDB-GENE-000329-1|UniProtKB=Q7ZVI7	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05963	MAO	RAT|RGD=61898|UniProtKB=P21396	Amine oxidase [flavin-containing] A	ISS	8602220	PubMed	PTHR43563:SF3	AMINE OXIDASE  FLAVIN-CONTAINING  A
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	CHICK|Ensembl=ENSGALG00000003634|UniProtKB=F1NT98	Uncharacterized protein	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00056	VEGF signaling pathway	P01417	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	XENTR|Xenbase=XB-GENE-493902|UniProtKB=F6R0B7	Uncharacterized protein (Fragment)	ISS			PTHR10937:SF2	GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE  ISOMERIZING  1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00477	GSK3beta	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	IDA	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00048	PI3 kinase pathway	P01192	p110	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	HUMAN|HGNC=19663|UniProtKB=Q9UBI6	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IC	3100519	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	EMENI|EnsemblGenome=CADANIAG00006296|UniProtKB=Q5ASG1	Putative synaptobrevin homologue SNC1/2 (Eurofung)	ISS			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	RAT|RGD=619751|UniProtKB=O88302	Guanine nucleotide-binding protein subunit alpha-15	ISS	11534853	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P06587	Nicotine pharmacodynamics pathway	P06590	GNG	TAKRU|Ensembl=ENSTRUG00000007253|UniProtKB=H2SZQ1	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000008751|UniProtKB=H2QC89	Uncharacterized protein	ISS	12507995	PubMed	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ORYSJ|Gene=Os01g0866100|UniProtKB=P0C540	Actin-7	IC	10974003	PubMed	PTHR11937:SF205	SUBFAMILY NOT NAMED
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00046	Oxidative stress response	P01135	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	TAS	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00054	Toll receptor signaling pathway	P01360	IKKbeta	MOUSE|MGI=MGI=1338071|UniProtKB=O88351	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00006	Apoptosis signaling pathway	P00260	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	HUMAN|HGNC=10004|UniProtKB=O75916	Regulator of G-protein signaling 9	IDA	9459445	PubMed	PTHR10845:SF170	REGULATOR OF G-PROTEIN SIGNALING 9
P00045	Notch signaling pathway	P01120	NIcs	CANLF|Ensembl=ENSCAFG00000019633|UniProtKB=F1PDC7	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00029	Huntington disease	P00797	p53	DANRE|ZFIN=ZDB-GENE-030814-2|UniProtKB=B0S576	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MACMU|Ensembl=ENSMMUG00000017346|UniProtKB=F7H9B8	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P00053	T cell activation	P01315	Calcineurin	HUMAN|HGNC=9315|UniProtKB=P16298	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	IGI	7532676	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00009	Axon guidance mediated by netrin	P00366	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	20264070	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00006	Apoptosis signaling pathway	P00318	PKCs	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00054	Toll receptor signaling pathway	P01352	p38	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	ISS	10995439	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00057	Wnt signaling pathway	P01446	Calcineurin	HUMAN|HGNC=9314|UniProtKB=Q08209	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	IDA	12091710	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	METAC|EnsemblGenome=MA_1524|UniProtKB=Q8TQL6	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00020	FAS signaling pathway	P00610	MKK4	CHICK|Ensembl=ENSGALG00000001001|UniProtKB=F1P3T1	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	TAS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05918	p38 MAPK pathway	P06021	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02776	Serine glycine biosynthesis	P03160	Phosphoglycerate dehydrogenase	STRCO|Gene=CAB37591|UniProtKB=Q9Z564	D-3-phosphoglycerate dehydrogenase	ISS			PTHR42938:SF9	FORMATE DEHYDROGENASE 1-RELATED
P02747	Histidine biosynthesis	P02991	Histidinephosphate aminotransferase	PYRAE|EnsemblGenome=PAE0958|UniProtKB=Q8ZY38	Histidinol-phosphate aminotransferase (HisC)	ISS			PTHR43643:SF3	SUBFAMILY NOT NAMED
P00053	T cell activation	P01319	PAK	MOUSE|MGI=MGI=1339975|UniProtKB=O88643	Serine/threonine-protein kinase PAK 1	IDA	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	HUMAN|HGNC=3015|UniProtKB=Q14195	Dihydropyrimidinase-related protein 3	ISS	3122041	gi	PTHR11647:SF57	DIHYDROPYRIMIDINASE-RELATED PROTEIN 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00049	Parkinson disease	P01234	GRK	MACMU|Ensembl=ENSMMUG00000015925|UniProtKB=F7AL30	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P00025	Hedgehog signaling pathway	P00682	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	10693759	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00591	PLCbeta	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00006	Apoptosis signaling pathway	P00274	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00233	CSL	ORNAN|Ensembl=ENSOANG00000006699|UniProtKB=F6ULE6	Uncharacterized protein	ISS	12145413	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	DICDI|dictyBase=DDB_G0290263|UniProtKB=Q9XZE5	Serine/threonine-protein phosphatase 2A catalytic subunit A	ISS	99379588	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04393	Ras Pathway	P04568	MKK3/6	CANLF|Ensembl=ENSCAFG00000018530|UniProtKB=F1PXD3	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00021	FGF signaling pathway	P00632	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01465	Ggamma	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	YEAST|SGD=S000000028|UniProtKB=P31109	Synaptobrevin homolog 1	ISS			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	DROME|FlyBase=FBgn0019947|UniProtKB=O02194	Presenilin homolog	TAS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00018	EGF receptor signaling pathway	P00547	PP2A	CHICK|Ensembl=ENSGALG00000001013|UniProtKB=Q5ZIV0	Serine/threonine-protein phosphatase	ISS			PTHR11668:SF24	SERINE/THREONINE-PROTEIN PHOSPHATASE 6 CATALYTIC SUBUNIT
P05731	GABA-B receptor II signaling	P05760	AC	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	RCA	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01080	AChE	PANTR|Ensembl=ENSPTRG00000015593|UniProtKB=H2QNP1	Carboxylic ester hydrolase	ISS	86008285	PubMed	PTHR43918:SF5	CHOLINESTERASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00128	Erb-B4	ORNAN|Ensembl=ENSOANG00000007021|UniProtKB=F7GAV2	Receptor protein-tyrosine kinase	ISS	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P05918	p38 MAPK pathway	P06041	Cdc42	BRAFL|Gene=BRAFLDRAFT_122664|UniProtKB=C3ZIB9	Putative uncharacterized protein	ISS	4757952	gi	PTHR24072:SF192	CDC42 HOMOLOG
P00021	FGF signaling pathway	P00640	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01275	P38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	TAS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00029	Huntington disease	P00780	Microtubule	XENTR|Xenbase=XB-GENE-482185|UniProtKB=Q6GLE7	Tubulin beta chain	ISS	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	TAS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02750	Lipoate_biosynthesis	P03003	Lipoyl-protein ligase	IXOSC|EnsemblGenome=ISCW016083|UniProtKB=B7P6C0	Lipoate-protein ligase B, putative (Fragment)	ISS			PTHR10993:SF7	LIPOYLTRANSFERASE 2, MITOCHONDRIAL-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05957	K+ channel	CHICK|Ensembl=ENSGALG00000016193|UniProtKB=E1BYI0	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00005	Angiogenesis	P00181	SHP2	MACMU|Ensembl=ENSMMUG00000013253|UniProtKB=F6ZJD8	Tyrosine-protein phosphatase non-receptor type	ISS	7681589	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00047	PDGF signaling pathway	P01159	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	BOVIN|Ensembl=ENSBTAG00000035084|UniProtKB=F1MLG5	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF22	FRIZZLED-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	PANTR|Ensembl=ENSPTRG00000001477|UniProtKB=H2Q0A5	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF338	INSULIN RECEPTOR-RELATED PROTEIN
P00034	Integrin signalling pathway	P00916	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00020	FAS signaling pathway	P00615	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00249	PAK	MACMU|Ensembl=ENSMMUG00000001387|UniProtKB=F7D0B4	Uncharacterized protein	ISS	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	RAT|RGD=621005|UniProtKB=Q08849	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00048	PI3 kinase pathway	P01200	SHIP	PANTR|Ensembl=ENSPTRG00000004031|UniProtKB=H2Q4C6	Inositol polyphosphate phosphatase-like 1	ISS	9824312	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P06211	BMP/activin signaling pathway-drosophila	P06254	Co-Smad	DROME|FlyBase=FBgn0011655|UniProtKB=O62609	Mothers against decapentaplegic homolog	RCA	9395284	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MOUSE|MGI=MGI=1339967|UniProtKB=B1AR69	Protein Myh13	ISS	10938134	PubMed	PTHR13140:SF504	MYOSIN-13
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00056	VEGF signaling pathway	P01414	PLC-gamma	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04393	Ras Pathway	P04559	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12676940	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00019	Endothelin signaling pathway	P00577	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IGI	12660731	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DICDI|dictyBase=DDB_G0289489|UniProtKB=P07828	Actin-18	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00034	Integrin signalling pathway	P00920	SOS	CHICK|Ensembl=ENSGALG00000013224|UniProtKB=F1NMA4	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05918	p38 MAPK pathway	P05920	MAPKAP-K2	PANTR|Ensembl=ENSPTRG00000001915|UniProtKB=H2Q104	Mitogen-activated protein kinase-activated protein kinase 2	ISS	10779545	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00036	Interleukin signaling pathway	P00983	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	BRAFL|Gene=BRAFLDRAFT_87235|UniProtKB=C3ZEV9	Putative uncharacterized protein	ISS			PTHR23050:SF245	AT16150P-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	MACMU|Ensembl=ENSMMUG00000017431|UniProtKB=F7HPP3	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00356	UNC-5	HUMAN|HGNC=18634|UniProtKB=Q6UXZ4	Netrin receptor UNC5D	ISS			PTHR12582:SF5	NETRIN RECEPTOR UNC5D
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00047	PDGF signaling pathway	P01143	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05918	p38 MAPK pathway	P06029	p38beta	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	RCA	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00005	Angiogenesis	P00223	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01275	P38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02761	Pantothenate biosynthesis	P03066	Aspartate decarboxylase	AQUAE|EnsemblGenome=aq_476|UniProtKB=O66773	Aspartate 1-decarboxylase	ISS			PTHR21012:SF0	ASPARTATE 1-DECARBOXYLASE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Ensembl=ENSPTRG00000016548|UniProtKB=H2QQC5	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	3755548	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00059	p53 pathway	G04696	Siah	DANRE|ZFIN=ZDB-GENE-010319-31|UniProtKB=Q7ZVG6	E3 ubiquitin-protein ligase Siah1	ISS	14985507	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00005	Angiogenesis	P00190	RasGAP	HUMAN|HGNC=9871|UniProtKB=P20936	Ras GTPase-activating protein 1	IDA	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	ARATH|TAIR=AT1G13890|UniProtKB=Q9LMG8	Putative SNAP25 homologous protein SNAP30	ISS	11067767	PubMed	PTHR19305:SF7	SNAP25 HOMOLOGOUS PROTEIN SNAP30-RELATED
P04393	Ras Pathway	P04559	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	IDA	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04393	Ras Pathway	P04541	p90RSK	HUMAN|HGNC=10430|UniProtKB=Q15418	Ribosomal protein S6 kinase alpha-1	ISS	12769834	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	176892	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01458	Protein Kinase C	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00018	EGF receptor signaling pathway	P00556	PLCgamma	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00012	Cadherin signaling pathway	P00477	GSK3beta	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-5861|UniProtKB=X1WDQ5	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00057	Wnt signaling pathway	P01429	Axin	PANTR|Ensembl=ENSPTRG00000009554|UniProtKB=H2QDP9	Uncharacterized protein	ISS	12356903	PubMed	PTHR10845:SF103	AXIN-2
P00052	TGF-beta signaling pathway	P01284	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00049	Parkinson disease	P01238	14-3-3	XENTR|Xenbase=XB-GENE-951350|UniProtKB=Q0V9W8	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	ISS	10407019	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CHICK|Ensembl=ENSGALG00000003157|UniProtKB=E1C523	Uncharacterized protein	IC	10938134	PubMed	PTHR13140:SF358	MYOSIN-7B
P00059	p53 pathway	P01486	Akt	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	TAS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	TAKRU|Ensembl=ENSTRUG00000007619|UniProtKB=H2T2K8	Uncharacterized protein	ISS	606023	OMIM	PTHR10917:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MOUSE|MGI=MGI=102891|UniProtKB=P51829	Adenylate cyclase type 7	IDA	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00056	VEGF signaling pathway	P01408	Akt/PKB	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00034	Integrin signalling pathway	P00916	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P04398	p53 pathway feedback loops 2	P04668	p53	RAT|RGD=1307083|UniProtKB=D4AA88	Protein Tp73	ISS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00038	JAK/STAT signaling pathway	P01027	STAT	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	14755057	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00009	Axon guidance mediated by netrin	P00366	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00053	T cell activation	P01326	CD3 delta	RAT|RGD=2304|UniProtKB=P19377	T-cell surface glycoprotein CD3 delta chain	IPI	9348303	PubMed	PTHR10570:SF5	T-CELL SURFACE GLYCOPROTEIN CD3 DELTA CHAIN
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00017	DNA replication	P00533	Pol delta	RAT|RGD=621839|UniProtKB=O54747	DNA polymerase delta catalytic subunit	ISS	92089082	PubMed	PTHR10322:SF23	DNA POLYMERASE DELTA CATALYTIC SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IC	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04393	Ras Pathway	P04567	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IDA	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00054	Toll receptor signaling pathway	P01352	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00020	FAS signaling pathway	P00601	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	8837781	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01171	PLCgamma	CAEEL|WormBase=WBGene00004038|UniProtKB=Q22070	Phosphoinositide phospholipase C	ISS			PTHR10336:SF91	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00010	B cell activation	P00367	NFAT	MACMU|Ensembl=ENSMMUG00000021843|UniProtKB=F6RNI3	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00965	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CAEBR|Gene=CBG17587|UniProtKB=A8XRA5	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00029	Huntington disease	P00788	Calpain	HUMAN|HGNC=1479|UniProtKB=P17655	Calpain-2 catalytic subunit	IDA	11675509	PubMed	PTHR10183:SF268	CALPAIN-2 CATALYTIC SUBUNIT
P00005	Angiogenesis	P00206	Wnt	MONDO|Ensembl=ENSMODG00000018415|UniProtKB=F6XUZ7	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	DROME|FlyBase=FBgn0011286|UniProtKB=Q24498	Ryanodine receptor	ISS	15858232	PubMed	PTHR13715:SF79	RYANODINE RECEPTOR
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	BOVIN|Ensembl=ENSBTAG00000014710|UniProtKB=P62833	Ras-related protein Rap-1A	ISS	1904317	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	CAEBR|Gene=CBG04201|UniProtKB=A8WWE8	Actin-related protein 2/3 complex subunit 5	ISS	12473693	PubMed	PTHR12644:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00054	Toll receptor signaling pathway	P01379	Tollip	MACMU|Ensembl=ENSMMUG00000003104|UniProtKB=F7DRR2	Toll-interacting protein	ISS			PTHR16461:SF5	TOLL-INTERACTING PROTEIN
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	BOVIN|Ensembl=ENSBTAG00000026403|UniProtKB=F1MD32	CREB binding protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P02775	Salvage pyrimidine ribonucleotides	P03156	CDP kinase	ECOLI|EcoGene=EG11701|UniProtKB=P0A8F4	Uridine kinase	ISS			PTHR10285:SF6	ATP-DEPENDENT KINASE TDA10-RELATED
P00029	Huntington disease	P00810	GAPDH	HUMAN|HGNC=24864|UniProtKB=O14556	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific	IPI			PTHR10836:SF79	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE, TESTIS-SPECIFIC
P05731	GABA-B receptor II signaling	P05752	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00029	Huntington disease	P00790	beta-Tubulin	MOUSE|MGI=MGI=107812|UniProtKB=P99024	Tubulin beta-5 chain	TAS	9454836	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	CHICK|Ensembl=ENSGALG00000004763|UniProtKB=F1NH33	Aldehyde dehydrogenase	IC	14724059	PubMed	PTHR43570:SF9	FATTY ALDEHYDE DEHYDROGENASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000001789|UniProtKB=F7GIU0	5-hydroxytryptamine receptor 1A	ISS	12441358	PubMed	PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P06587	Nicotine pharmacodynamics pathway	P06589	PPP1R1B	HUMAN|HGNC=9287|UniProtKB=Q9UD71	Protein phosphatase 1 regulatory subunit 1B	RCA	3339428	PubMed	PTHR15417:SF2	PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 1B
P04397	p53 pathway by glucose deprivation	P04641	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00641	SOS	CHICK|Ensembl=ENSGALG00000013224|UniProtKB=F1NMA4	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00049	Parkinson disease	P01211	ERK	MOUSE|MGI=MGI=2652894|UniProtKB=Q80Y86	Mitogen-activated protein kinase 15	ISS	9891064	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	ANOGA|EnsemblGenome=AGAP002156|UniProtKB=Q7QK53	AGAP002156-PA	IDA			PTHR24241:SF59	ADIPOKINETIC HORMONE RECEPTOR, ISOFORM C
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04397	p53 pathway by glucose deprivation	P04636	S6K	HUMAN|HGNC=10437|UniProtKB=Q9UBS0	Ribosomal protein S6 kinase beta-2	IDA	6755374	gi	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00057	Wnt signaling pathway	P01444	Wnt	PANTR|Ensembl=ENSPTRG00000009321|UniProtKB=H2QD96	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	THEKO|EnsemblGenome=TK1002|UniProtKB=Q5JIE6	Adenylosuccinate synthetase	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	CANLF|Ensembl=ENSCAFG00000008683|UniProtKB=F1PBJ8	Uncharacterized protein	ISS			PTHR11699:SF233	ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	CHICK|Ensembl=ENSGALG00000015835|UniProtKB=F1NZT2	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	ARATH|TAIR=AT3G60180|UniProtKB=Q8VY84	Probable UMP-CMP kinase 1	ISS			PTHR23359:SF107	UMP-CMP KINASE
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00006	Apoptosis signaling pathway	P00269	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	DEIRA|EnsemblGenome=DR_0640|UniProtKB=Q9RWM6	S-adenosylmethionine synthase	ISS			PTHR11964:SF1	S-ADENOSYLMETHIONINE SYNTHASE
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	RCA	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00983	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00981	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00020	FAS signaling pathway	P00616	Nuclear Lamin	STRPU|EnsemblGenome=SPU_002219|UniProtKB=W4XFQ5	Uncharacterized protein	TAS	11165516	PubMed	PTHR23239:SF234	LAMIN DM0-RELATED
P00006	Apoptosis signaling pathway	P00310	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00029	Huntington disease	P00805	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P02748	Isoleucine biosynthesis	P02995	Threonine dehydratase	SCHPO|PomBase=SPBC1677.03c|UniProtKB=O94634	Threonine dehydratase, mitochondrial	ISS			PTHR43714:SF1	THREONINE DEHYDRATASE, MITOCHONDRIAL
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04375	5HT3 type receptor mediated signaling pathway	P04421	5HT transporter	MOUSE|MGI=MGI=96285|UniProtKB=Q60857	Sodium-dependent serotonin transporter	ISS	7681602	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MOUSE|MGI=MGI=95817|UniProtKB=Q8BMF5	Glutamate receptor ionotropic, kainate 4	ISS	12871085	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00774	Dynein complex	MOUSE|MGI=MGI=107750|UniProtKB=O88487	Cytoplasmic dynein 1 intermediate chain 2	IPI	9454836	PubMed	PTHR12442:SF22	CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000020224|UniProtKB=H2Q9G3	Mitogen-activated protein kinase 6	ISS	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00048	PI3 kinase pathway	P01199	Galpha	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	IC	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00053	T cell activation	P01320	PLC-gamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00020	FAS signaling pathway	P00607	Pro-Caspase6	MOUSE|MGI=MGI=1312921|UniProtKB=O08738	Caspase-6	IGI	11463840	PubMed	PTHR10454:SF164	CASPASE-6
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	MOUSE|MGI=MGI=88396|UniProtKB=P12657	Muscarinic acetylcholine receptor M1	ISS	10069496	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00034	Integrin signalling pathway	P00948	Rho	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	IGI	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IDA	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00577	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00870	IL2	MOUSE|MGI=MGI=1859324|UniProtKB=Q9JLA2	Interleukin-36 alpha	IDA			PTHR10078:SF25	INTERLEUKIN-36 ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	TAS	15572354	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	MOUSE|MGI=MGI=88390|UniProtKB=P01216	Glycoprotein hormones alpha chain	ISS	89325834	PubMed	PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	CANLF|Gene=PSEN1|UniProtKB=Q6RH31	Presenilin-1	ISS	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	METAC|EnsemblGenome=MA_1524|UniProtKB=Q8TQL6	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00006	Apoptosis signaling pathway	P00269	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	97102671	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00057	Wnt signaling pathway	P01438	PP2A	MACMU|Ensembl=ENSMMUG00000013047|UniProtKB=F7H808	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00922	Collagen	CHICK|Gene=COL1A2|UniProtKB=P02467	Collagen alpha-2(I) chain (Fragments)	IDA	10778855	PubMed	PTHR24023:SF568	COLLAGEN ALPHA-2 I  CHAIN
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000015092|UniProtKB=F6WUV0	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF96	CADHERIN-12
P04393	Ras Pathway	P04541	p90RSK	RAT|RGD=1563860|UniProtKB=D3Z8E0	Ribosomal protein S6 kinase	ISS	2779569	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00848	Grb	MOUSE|MGI=MGI=1333842|UniProtKB=O89100	GRB2-related adaptor protein 2	IDA	51702266	gi	PTHR24418:SF299	GRB2-RELATED ADAPTER PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	CHICK|Ensembl=ENSGALG00000009927|UniProtKB=Q5ZHX1	Ras-related protein Rap-1b	ISS	8576107	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01448	CBP	HUMAN|HGNC=3373|UniProtKB=Q09472	Histone acetyltransferase p300	IDA	8413673	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	CHICK|Ensembl=ENSGALG00000005198|UniProtKB=F1P4J0	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01444	Wnt	RAT|RGD=1304988|UniProtKB=A0A0G2K6Q8	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	BATDJ|Gene=BATDEDRAFT_15405|UniProtKB=F4NUL6	Alpha-Beta tubulin	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	IDA	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00010	B cell activation	P00371	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IDA	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00053	T cell activation	P01336	Jnk	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04570	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01275	P38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-040426-2280|UniProtKB=Q6P025	Gnb3 protein	ISS	11313908	PubMed	PTHR19850:SF35	GNB3 PROTEIN
P00045	Notch signaling pathway	P01116	Delta	MOUSE|MGI=MGI=1096877|UniProtKB=O88516	Delta-like protein 3	IEP	12175503	PubMed	PTHR24044:SF308	DELTA-LIKE PROTEIN 3
P04393	Ras Pathway	P04543	MEKK1/4	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	IDA	8643568	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000012314|UniProtKB=F7DGM2	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF81	CADHERIN-4
P05918	p38 MAPK pathway	P05921	MKP5	RAT|RGD=1310844|UniProtKB=D3ZBG7	Dual specificity phosphatase 10 (Predicted)	ISS	11856337	PubMed	PTHR10159:SF299	DUAL SPECIFICITY PROTEIN PHOSPHATASE 10
P00048	PI3 kinase pathway	P01194	S6K	PANTR|Ensembl=ENSPTRG00000003957|UniProtKB=H2Q486	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	ENTHI|EnsemblGenome=EHI_170040|UniProtKB=Q7Z0T4	Longin-type vesicle-associated membrane protein, putative	ISS	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P02740	De novo pyrimidine ribonucleotides biosythesis	P02928	Dihydroorotase	STRCO|EnsemblGenome=CAB93366|UniProtKB=Q9KXR3	Dihydroorotase	ISS			PTHR43668:SF1	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00642	MEK1-2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05731	GABA-B receptor II signaling	P05752	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	8787761	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05918	p38 MAPK pathway	P06020	p38delta	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	RCA	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05913	Enkephalin release	P05974	G-Protein (i)	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	NEUCR|EnsemblGenome=EFNCRG00000006341|UniProtKB=P87253	Protein kinase C-like	ISS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05918	p38 MAPK pathway	P06042	4E-BP1	MOUSE|MGI=MGI=103267|UniProtKB=Q60876	Eukaryotic translation initiation factor 4E-binding protein 1	RCA	15494402	PubMed	PTHR12669:SF14	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	DANRE|ZFIN=ZDB-GENE-990415-85|UniProtKB=O13168	Protein groucho-1 (Fragment)	IDA	9783586	PubMed	PTHR10814:SF24	TRANSDUCIN-LIKE ENHANCER PROTEIN 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00015	Circadian clock system	P00505	Cry	HUMAN|HGNC=2384|UniProtKB=Q16526	Cryptochrome-1	IEP	14507900	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00006	Apoptosis signaling pathway	P00292	IkappaB	BOVIN|Ensembl=ENSBTAG00000016683|UniProtKB=Q8WNW7	NF kappa B inhibitor alpha (Fragment)	ISS	14665694	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00034	Integrin signalling pathway	P00922	Collagen	MOUSE|MGI=MGI=109442|UniProtKB=A2ARA8	Integrin alpha-8	IDA			PTHR23220:SF5	INTEGRIN ALPHA-8
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00206	Wnt	HUMAN|HGNC=16265|UniProtKB=Q9H1J7	Protein Wnt-5b	ISS	8717036	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	RCA	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00021	FGF signaling pathway	P00638	PLCgamma	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P02728	Arginine biosynthesis	P02841	argininosuccinate lyase	YEAST|SGD=S000001060|UniProtKB=P04076	Argininosuccinate lyase	ISS			PTHR43814:SF1	ARGININOSUCCINATE LYASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CHLRE|EnsemblGenome=CHLREDRAFT_24392|UniProtKB=A8JAV1	Actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00048	PI3 kinase pathway	P01179	PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04557	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IDA	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01320	PLC-gamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00021	FGF signaling pathway	P00629	PP2A	BOVIN|Ensembl=ENSBTAG00000018317|UniProtKB=F1MG56	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B	ISS	137056	PubMed	PTHR11871:SF2	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B ALPHA ISOFORM
P00034	Integrin signalling pathway	P00924	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01237	Complex I	PANTR|Ensembl=ENSPTRG00000011423|UniProtKB=H2RBN7	Uncharacterized protein	ISS	3100899	PubMed	PTHR10371:SF3	NADH DEHYDROGENASE  UBIQUINONE  FLAVOPROTEIN 2, MITOCHONDRIAL
P00006	Apoptosis signaling pathway	P00324	NIK	RAT|RGD=1310487|UniProtKB=D3ZTD1	Mitogen-activated protein kinase kinase kinase 14 (Predicted), isoform CRA_a	ISS			PTHR24361:SF226	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 14
P00023	General transcription regulation	P00668	TFIIB	BOVIN|Gene=GTF2B|UniProtKB=Q2KIN8	Transcription initiation factor IIB	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P00004	Alzheimer disease-presenilin pathway	P00111	C99	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00029	Huntington disease	P00805	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00196	VRAP	HUMAN|HGNC=10821|UniProtKB=Q9NP31	SH2 domain-containing protein 2A	IDA	10692392	PubMed	PTHR14388:SF9	SH2 DOMAIN-CONTAINING PROTEIN 2A
P00049	Parkinson disease	P01219	SAPK	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00627	ERK1-2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-7596|UniProtKB=Q6PBN9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF26	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT GAMMA-T1
P00036	Interleukin signaling pathway	P00983	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	NAS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MOUSE|MGI=MGI=1202403|UniProtKB=G3X8Z7	MCG5735	IC			PTHR18945:SF489	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-9
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00010	B cell activation	P00383	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Ensembl=ENSBTAG00000013632|UniProtKB=E1B965	Uncharacterized protein	ISS	11431030	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00007	Axon guidance mediated by semaphorins	P00338	Neuropilin 1	HUMAN|HGNC=8004|UniProtKB=O14786	Neuropilin-1	ISS	9288754	PubMed	PTHR44185:SF1	NEUROPILIN-1
P00005	Angiogenesis	P00219	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	91056091	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	IDA	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00029	Huntington disease	P00780	Microtubule	DROME|FlyBase=FBgn0052396|UniProtKB=Q9VRX3	Probable tubulin beta chain CG32396	IDA	9454836	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	DANRE|ZFIN=ZDB-GENE-020419-19|UniProtKB=Q8JHE0	Casein kinase 1-alphaLS	IDA	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P04398	p53 pathway feedback loops 2	G04714	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	IGI	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IDA	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	TAKRU|Ensembl=ENSTRUG00000015213|UniProtKB=H2UPJ1	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF356	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00641	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	MYCTU|EnsemblGenome=Rv1699|UniProtKB=P9WHK7	CTP synthase	ISS			PTHR11550:SF0	CTP SYNTHASE
P00035	Interferon-gamma signaling pathway	P00957	IFNGR2	MOUSE|MGI=MGI=107654|UniProtKB=Q63953	Ifngr2 protein	TAS	14525967	PubMed	PTHR20859:SF46	INTERFERON GAMMA RECEPTOR 2
P00060	Ubiquitin proteasome pathway	P01491	E2	CAEEL|WormBase=WBGene00002344|UniProtKB=P35129	Ubiquitin-conjugating enzyme E2 2	ISS			PTHR24068:SF74	FI16911P1-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00046	Oxidative stress response	P01128	MEF-2	PANTR|Ensembl=ENSPTRG00000007496|UniProtKB=H2QA54	Uncharacterized protein	ISS	11274345	PubMed	PTHR11945:SF145	MYOCYTE-SPECIFIC ENHANCER FACTOR 2A
P00029	Huntington disease	P00807	Actin	SCHMA|EnsemblGenome=Smp_202970|UniProtKB=G4VLN1	Putative uncharacterized protein Smp_202970	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00018	EGF receptor signaling pathway	P00555	MKK4,7	PANTR|Ensembl=ENSPTRG00000008783|UniProtKB=H2QCA7	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00019	Endothelin signaling pathway	P00568	PKC	DANRE|ZFIN=ZDB-GENE-041001-104|UniProtKB=Q5TZD4	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00029	Huntington disease	P00777	CBP	CAEEL|WormBase=WBGene00000366|UniProtKB=P34545	Protein cbp-1	IDA	10664585	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00036	Interleukin signaling pathway	P00997	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	8264585	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00012	Cadherin signaling pathway	P00474	Wnt	CHICK|Ensembl=ENSGALG00000005123|UniProtKB=Q9DEB8	Protein Wnt	IDA	8717036	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00020	FAS signaling pathway	P00601	c-Jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=105976|UniProtKB=Q99104	Unconventional myosin-Va	IC			PTHR13140:SF273	UNCONVENTIONAL MYOSIN-VA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04395	Vasopressin synthesis	P04597	Signal Peptide	TAKRU|Ensembl=ENSTRUG00000015413|UniProtKB=H2UR30	Uncharacterized protein	ISS	192340	OMIM	PTHR11681:SF13	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00564	Rac	DICPU|Gene=DICPUDRAFT_168754|UniProtKB=F0ZQR3	Rac1B, RHO family GTPase	ISS	94124042	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01456	beta-arrestin	RAT|RGD=2157|UniProtKB=P29067	Beta-arrestin-2	IDA	9388255	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00006	Apoptosis signaling pathway	P00269	MAPK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00025	Hedgehog signaling pathway	P00682	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00219	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00005	Angiogenesis	P00193	SOS-1	CHICK|Ensembl=ENSGALG00000013224|UniProtKB=F1NMA4	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00021	FGF signaling pathway	P00632	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MOUSE|MGI=MGI=104589|UniProtKB=P63268	Actin, gamma-enteric smooth muscle	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00018	EGF receptor signaling pathway	P00557	PI3K	CAEEL|WormBase=WBGene00006932|UniProtKB=Q9TXI7	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	11927551	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00001	Adrenaline and noradrenaline biosynthesis	P00062	TH	DROME|FlyBase=FBgn0005626|UniProtKB=P18459	Tyrosine 3-monooxygenase	ISS	12480184	PubMed	PTHR11473:SF15	TYROSINE 3-MONOOXYGENASE
P00036	Interleukin signaling pathway	P00990	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00790	beta-Tubulin	DICDI|dictyBase=DDB_G0269196|UniProtKB=P32256	Tubulin beta chain	TAS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	CHICK|Gene=BMPR1B|UniProtKB=Q05438	Bone morphogenetic protein receptor type-1B	TAS	9395284	PubMed	PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P00047	PDGF signaling pathway	P01143	ERK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01455	Smad4	RAT|RGD=3030|UniProtKB=P97588	Mothers against decapentaplegic homolog 1	IDA	9395284	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P00008	Axon guidance mediated by Slit/Robo	P00351	Cxcr4	CANLF|Ensembl=ENSCAFG00000005109|UniProtKB=Q3LSL6	C-X-C chemokine receptor type 4	ISS	4503175	gi	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P00007	Axon guidance mediated by semaphorins	P00339	CRMP	MOUSE|MGI=MGI=1928679|UniProtKB=Q9EQF5	Dihydropyrimidinase	ISS			PTHR11647:SF50	DIHYDROPYRIMIDINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06717	gnas	MOUSE|MGI=MGI=95777|UniProtKB=Q6R0H7	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas	RCA	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=12779|UniProtKB=O14905	Protein Wnt-9b	IDA	11266476	PubMed	PTHR12027:SF84	PROTEIN WNT-9B
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00018	EGF receptor signaling pathway	P00561	STAT	PANTR|Ensembl=ENSPTRG00000009200|UniProtKB=H2QD20	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	RAT|RGD=2395|UniProtKB=P07756	Carbamoyl-phosphate synthase [ammonia], mitochondrial	ISS			PTHR11405:SF38	CARBAMOYL-PHOSPHATE SYNTHASE  AMMONIA , MITOCHONDRIAL
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IC	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00018	EGF receptor signaling pathway	P00551	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	DROME|FlyBase=FBgn0010223|UniProtKB=Q05337	Guanine nucleotide-binding protein G(f) subunit alpha	ISS			PTHR10218:SF229	GUANINE NUCLEOTIDE-BINDING PROTEIN G F  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	HUMAN|HGNC=1950|UniProtKB=P11229	Muscarinic acetylcholine receptor M1	IDA	12181435	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	CANLF|Ensembl=ENSCAFG00000016051|UniProtKB=F1Q382	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	ARATH|TAIR=AT3G12980|UniProtKB=Q9LE42	Histone acetyltransferase HAC5	IDA			PTHR13808:SF1	NEJIRE, ISOFORM C
P00053	T cell activation	P01312	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00048	PI3 kinase pathway	P01199	Galpha	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS			PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00045	Notch signaling pathway	P01103	Next	RAT|RGD=620761|UniProtKB=Q9R172	Neurogenic locus notch homolog protein 3	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PHANO|EnsemblGenome=SNOG_01139|UniProtKB=H2KNE6	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05957	K+ channel	PANTR|Ensembl=ENSPTRG00000020614|UniProtKB=H2QWR7	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00057	Wnt signaling pathway	P01438	PP2A	CHICK|Ensembl=ENSGALG00000011260|UniProtKB=Q5F3C6	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00059	p53 pathway	P01486	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00020	FAS signaling pathway	P00615	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	HUMAN|HGNC=10430|UniProtKB=Q15418	Ribosomal protein S6 kinase alpha-1	ISS	6755374	gi	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00013	Cell cycle	P00480	Proteasome	MONDO|Ensembl=ENSMODG00000003986|UniProtKB=F7DST4	Uncharacterized protein	ISS	12477932	PubMed	PTHR10855:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	TAS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	HUMAN|HGNC=1736|UniProtKB=P60953	Cell division control protein 42 homolog	ISS	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	STRPU|EnsemblGenome=SPU_003166|UniProtKB=W4XIE2	Uncharacterized protein	IEP	12356903	PubMed	PTHR11514:SF95	MYC PROTEIN
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00260	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02747	Histidine biosynthesis	P02985	Histidinol dehydrogenase	SCHPO|PomBase=SPBC1711.13|UniProtKB=Q9P777	Histidinol dehydrogenase	ISS			PTHR21256:SF2	HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN
P00056	VEGF signaling pathway	P01410	Caspase9	RAT|RGD=61867|UniProtKB=Q9JHK1	Caspase	ISS	9390557	PubMed	PTHR10454:SF157	CASPASE-9
P00038	JAK/STAT signaling pathway	P01033	PTP	RAT|RGD=3451|UniProtKB=P04157	Receptor-type tyrosine-protein phosphatase C	ISS	1672451	PubMed	PTHR19134:SF284	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C
P00057	Wnt signaling pathway	P01452	NFAT	BOVIN|Ensembl=ENSBTAG00000018270|UniProtKB=F1MGR9	Uncharacterized protein	ISS	12787506	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00010	B cell activation	P00384	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04393	Ras Pathway	P04557	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00009	Axon guidance mediated by netrin	P00359	NFAT	RAT|RGD=1308692|UniProtKB=A0A0G2JTY4	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 (Predicted), isoform CRA_b	ISS	12787506	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00006	Apoptosis signaling pathway	P00274	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	RAT|RGD=2523|UniProtKB=P25115	D(1B) dopamine receptor	ISS	11248120	PubMed	PTHR43893:SF8	D 1B  DOPAMINE RECEPTOR
P00047	PDGF signaling pathway	P01145	c-fos	HUMAN|HGNC=12594|UniProtKB=Q15853	Upstream stimulatory factor 2	ISS			PTHR12565:SF11	UPSTREAM STIMULATORY FACTOR 2
P04392	P53 pathway feedback loops 1	P04540	Cop-1	MOUSE|MGI=MGI=1347046|UniProtKB=Q9R1A8	E3 ubiquitin-protein ligase RFWD2	ISS	15103385	PubMed	PTHR44080:SF1	E3 UBIQUITIN-PROTEIN LIGASE RFWD2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	ANOGA|EnsemblGenome=AGAP005913|UniProtKB=Q7Q6D2	AGAP005913-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P02742	Tetrahydrofolate biosynthesis	P02941	Dihydroneopterin aldolase	BACSU|EnsemblGenome=BSU00780|UniProtKB=P28823	Dihydroneopterin aldolase	ISS			PTHR42844:SF1	DIHYDRONEOPTERIN ALDOLASE
P00019	Endothelin signaling pathway	P00587	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00182	p38MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00313	IKK	MOUSE|MGI=MGI=1338071|UniProtKB=O88351	Inhibitor of nuclear factor kappa-B kinase subunit beta	IDA	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00008	Axon guidance mediated by Slit/Robo	P00342	Slit	RAT|RGD=69311|UniProtKB=O88280	Slit homolog 3 protein	ISS			PTHR24373:SF15	SLIT HOMOLOG 3 PROTEIN
P00029	Huntington disease	P00796	Kainate receptor	MOUSE|MGI=MGI=95814|UniProtKB=Q60934	Glutamate receptor ionotropic, kainate 1	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P02731	Biotin biosynthesis	P02856	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	STRCO|EnsemblGenome=CAC01469|UniProtKB=Q9FCC2	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	ISS			PTHR42684:SF3	ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04392	P53 pathway feedback loops 1	P04539	p53	MACMU|Ensembl=ENSMMUG00000016466|UniProtKB=F7GBH1	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CAEEL|WormBase=WBGene00010545|UniProtKB=G5EBG3	CBP/p300 homolog	TAS	10823891	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	RCA	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00029	Huntington disease	P00807	Actin	RAT|RGD=2026|UniProtKB=P68035	Actin, alpha cardiac muscle 1	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	9298898	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	HUMAN|HGNC=903|UniProtKB=O15169	Axin-1	IEP	12549854	PubMed	PTHR10845:SF11	AXIN-1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	IC	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00005	Angiogenesis	P00196	VRAP	PANTR|Ensembl=ENSPTRG00000001476|UniProtKB=H2R8K0	Uncharacterized protein	ISS	10692392	PubMed	PTHR14388:SF9	SH2 DOMAIN-CONTAINING PROTEIN 2A
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	CHICK|Ensembl=ENSGALG00000003157|UniProtKB=E1C523	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF358	MYOSIN-7B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=88398|UniProtKB=Q9ERZ3	Muscarinic acetylcholine receptor M3	IDA			PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	PANTR|Ensembl=ENSPTRG00000012427|UniProtKB=H2QIN7	Mitogen-activated protein kinase kinase kinase 2	ISS	21735556	gi	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	IDA	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00034	Integrin signalling pathway	P00912	Arp2/3	MONDO|Ensembl=ENSMODG00000007194|UniProtKB=F6X9N6	Actin-related protein 2/3 complex subunit 5	ISS	12932731	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00047	PDGF signaling pathway	P01143	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	MOUSE|MGI=MGI=98729|UniProtKB=Q62312	TGF-beta receptor type-2	TAS	9395284	PubMed	PTHR23255:SF55	TGF-BETA RECEPTOR TYPE-2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	STRPU|Gene=CYIIIA|UniProtKB=P53474	Actin, cytoskeletal 3A	IDA	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	ANOGA|EnsemblGenome=AGAP002945|UniProtKB=Q7PRA2	AGAP002945-PA	ISS			PTHR43382:SF2	BIFUNCTIONAL GLUTAMATE/PROLINE--TRNA LIGASE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	RAT|RGD=1590218|UniProtKB=D3ZXY4	Protein Aldh8a1	ISS			PTHR43720:SF2	ALDEHYDE DEHYDROGENASE FAMILY 8 MEMBER A1
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000008714|UniProtKB=F7E1N0	Adenosine receptor A1	ISS	11781138	PubMed	PTHR24246:SF1	ADENOSINE RECEPTOR A1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00048	PI3 kinase pathway	P01205	NOS	PANTR|Ensembl=ENSPTRG00000019868|UniProtKB=H2QVM2	Nitric oxide synthase	ISS	93055452	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00052	TGF-beta signaling pathway	P01286	TGFbeta	PANTR|Ensembl=ENSPTRG00000012008|UniProtKB=H2QI11	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF39	BONE MORPHOGENETIC PROTEIN 10
P00019	Endothelin signaling pathway	P00589	Akt	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	IGI	14526383	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00973	PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00005	Angiogenesis	P00204	PLD	HUMAN|HGNC=9068|UniProtKB=O14939	Phospholipase D2	ISS	15030398	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P00036	Interleukin signaling pathway	P00981	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	TAS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02738	De novo purine biosynthesis	P02900	AICAR transformylase	CAEEL|WormBase=WBGene00016957|UniProtKB=Q95QQ4	5-Aminoimidazole-4-carboxamide ribonucleotide formylTransferase/IMP Cyclohydrolase homolog	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	DROME|FlyBase=FBgn0010399|UniProtKB=Q24418	Glutamate [NMDA] receptor subunit 1	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P02738	De novo purine biosynthesis	P02892	5-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase	BOVIN|Gene=ADSL|UniProtKB=A3KN12	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00017	DNA replication	P00530	Top	PANTR|Ensembl=ENSPTRG00000014699|UniProtKB=H2QM73	DNA topoisomerase 2	RCA			PTHR10169:SF36	DNA TOPOISOMERASE 2-BETA
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00005	Angiogenesis	P00221	JNK1	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00508	Cofilin	HUMAN|HGNC=1875|UniProtKB=Q9Y281	Cofilin-2	ISS			PTHR11913:SF15	COFILIN-2
P00053	T cell activation	P01300	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00632	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01455	Smad4	PANTR|Ensembl=ENSPTRG00000010028|UniProtKB=H2QEJ6	Mothers against decapentaplegic homolog	ISS	9395284	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P00049	Parkinson disease	P01234	GRK	MOUSE|MGI=MGI=87941|UniProtKB=Q3UYH7	Beta-adrenergic receptor kinase 2	ISS	10852916	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00005	Angiogenesis	P00204	PLD	HUMAN|HGNC=9067|UniProtKB=Q13393	Phospholipase D1	IDA	15668389	PubMed	PTHR18896:SF57	PHOSPHOLIPASE D1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00012	Cadherin signaling pathway	P00475	Frizzled	DROME|FlyBase=FBgn0027343|UniProtKB=O77438	Frizzled-3	IDA	8717036	PubMed	PTHR11309:SF125	FRIZZLED-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00005	Angiogenesis	P00239	Eph	CHICK|Ensembl=ENSGALG00000029175|UniProtKB=Q9PUJ4	Ephrin-B2	ISS			PTHR11304:SF18	EPHRIN-B2
P00046	Oxidative stress response	P01124	Myc	HUMAN|HGNC=7553|UniProtKB=P01106	Myc proto-oncogene protein	TAS	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	XENTR|Xenbase=XB-GENE-491618|UniProtKB=Q6P378	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04373	5HT1 type receptor mediated signaling pathway	P04406	AC	RAT|RGD=619966|UniProtKB=F1LQT1	Adenylate cyclase 7	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	TAS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05917	Opioid proopiomelanocortin pathway	P06009	K+ channel	CHICK|Ensembl=ENSGALG00000016193|UniProtKB=E1BYI0	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00015	Circadian clock system	P00504	Per	PANTR|Ensembl=ENSPTRG00000000099|UniProtKB=H2R1W8	Uncharacterized protein	ISS	15700718	PubMed	PTHR11269:SF13	PERIOD CIRCADIAN PROTEIN HOMOLOG 3
P00056	VEGF signaling pathway	P01412	HSP27	PANTR|Ensembl=ENSPTRG00000034105|UniProtKB=H2R4Z0	Uncharacterized protein	ISS			PTHR11527:SF163	HEAT SHOCK PROTEIN BETA-2
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00036	Interleukin signaling pathway	P00976	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g167737|UniProtKB=A7S8I3	Predicted protein	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00011	Blood coagulation	P00451	Kininogen	HUMAN|HGNC=6383|UniProtKB=P01042	Kininogen-1	ISS	386852	gi	PTHR13814:SF12	KININOGEN-1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04398	p53 pathway feedback loops 2	P04651	Ras	CAEBR|Gene=CBG06092|UniProtKB=A8X0X5	Protein CBR-LET-60	ISS	22022015	PubMed	PTHR24070:SF385	GTPASE HRAS
P00021	FGF signaling pathway	P00628	JNK1-3	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	HUMAN|HGNC=21172|UniProtKB=Q7Z6V5	tRNA-specific adenosine deaminase 2	ISS			PTHR11079:SF92	TRNA-SPECIFIC ADENOSINE DEAMINASE 2
P00057	Wnt signaling pathway	P01443	Phospholipase C	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05731	GABA-B receptor II signaling	P05754	Ggamma	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00019	Endothelin signaling pathway	P00589	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	TAS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04393	Ras Pathway	P04572	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00048	PI3 kinase pathway	P01188	Gbetagamma	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000022550|UniProtKB=F6Y9I6	Serine/threonine-protein kinase	ISS	8078925	PubMed	PTHR22968:SF9	SERINE/THREONINE-PROTEIN KINASE D1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00021	FGF signaling pathway	P00632	Akt	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	IGI	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	CANLF|Ensembl=ENSCAFG00000010476|UniProtKB=F1PS94	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00034	Integrin signalling pathway	P00912	Arp2/3	ORNAN|Ensembl=ENSOANG00000007724|UniProtKB=F6QTB5	Uncharacterized protein	ISS	12963527	gi	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00053	T cell activation	P01294	NFAT	BOVIN|Ensembl=ENSBTAG00000018270|UniProtKB=F1MGR9	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00005	Angiogenesis	P00223	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00188	Ets	RAT|RGD=2583|UniProtKB=P41156	Protein C-ets-1	ISS	15579511	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00005	Angiogenesis	P00194	Paxillin	PANTR|Ensembl=ENSPTRG00000005527|UniProtKB=H2Q704	Paxillin	ISS	7579684	PubMed	PTHR24216:SF11	PAXILLIN
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04570	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01292	RSmads	DROME|FlyBase=FBgn0025800|UniProtKB=O96660	Mothers against decapentaplegic homolog	TAS	9395284	PubMed	PTHR13703:SF25	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	BOVIN|Ensembl=ENSBTAG00000047202|UniProtKB=G3N3K3	Uncharacterized protein	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00005	Angiogenesis	P00223	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01429	Axin	XENTR|Xenbase=XB-GENE-486781|UniProtKB=F6XWP7	Uncharacterized protein	ISS	9554852	PubMed	PTHR10845:SF11	AXIN-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	RAT|RGD=3188|UniProtKB=Q9QW30	Neurogenic locus notch homolog protein 2	IDA	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BOVIN|Gene=ACTR2|UniProtKB=A7MB62	Actin-related protein 2	ISS	11889126	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00019	Endothelin signaling pathway	P00590	IP3 R	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00052	TGF-beta signaling pathway	P01284	JNK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=101848|UniProtKB=P62881	Guanine nucleotide-binding protein subunit beta-5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02740	De novo pyrimidine ribonucleotides biosythesis	P02928	Dihydroorotase	LEIMA|EnsemblGenome=LmjF.16.0580|UniProtKB=Q4QEW1	Putative dihydroorotase	ISS			PTHR43668:SF2	ALLANTOINASE
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	MOUSE|MGI=MGI=1859544|UniProtKB=Q9R0N8	Synaptotagmin-6	RCA			PTHR10024:SF45	SYNAPTOTAGMIN-6
P00052	TGF-beta signaling pathway	P01275	P38	DROME|FlyBase=FBgn0015765|UniProtKB=O62618	Mitogen-activated protein kinase 14A	TAS	9417090	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04427	5HT4 Receptor	PANTR|Ensembl=ENSPTRG00000017389|UniProtKB=H2R334	Uncharacterized protein	ISS	12441358	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P02746	Heme biosynthesis	P02973	Uroporphyrinogen methyltransferase	GLOVI|Gene=BAC89175|UniProtKB=Q7NL92	Uroporphyrinogen III synthase/methyltransferase	ISS			PTHR21091:SF16	SIROHEME SYNTHASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00058	mRNA splicing	P01476	U4	RAT|RGD=1310555|UniProtKB=A0A0G2JTI7	Protein Prpf3	ISS	12875835	PubMed	PTHR14212:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3
P00006	Apoptosis signaling pathway	P00310	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00376	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P00023	General transcription regulation	P00658	TBP-associated factors	HUMAN|HGNC=11534|UniProtKB=Q15572	TATA box-binding protein-associated factor RNA polymerase I subunit C	ISS	604905	OMIM	PTHR15319:SF1	TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT C
P00047	PDGF signaling pathway	P01160	IP3 receptor	DROME|FlyBase=FBgn0010051|UniProtKB=P29993	Inositol 1,4,5-trisphosphate receptor	ISS	4262086	gi	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00036	Interleukin signaling pathway	P00990	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00045	Notch signaling pathway	G01541	E(spl)-C genes	DROME|FlyBase=FBgn0002631|UniProtKB=P13096	Enhancer of split m5 protein	TAS	14973298	PubMed	PTHR10985:SF12	ENHANCER OF SPLIT M3 PROTEIN-RELATED
P00010	B cell activation	P00391	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00057	Wnt signaling pathway	P01428	Frizzled	PANTR|Ensembl=ENSPTRG00000012813|UniProtKB=H2QJ90	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF31	FRIZZLED-7
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02740	De novo pyrimidine ribonucleotides biosythesis	P02928	Dihydroorotase	ARATH|TAIR=AT4G22930|UniProtKB=O04904	Dihydroorotase, mitochondrial	RCA			PTHR43137:SF1	DIHYDROOROTASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=1351344|UniProtKB=Q68ED2	Metabotropic glutamate receptor 7	ISS	12351712	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	SCHPO|PomBase=SPAC6F6.10c|UniProtKB=O14241	Actin-related protein 2/3 complex subunit 2	ISS			PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00057	Wnt signaling pathway	P01456	beta-arrestin	MOUSE|MGI=MGI=98227|UniProtKB=P20443	S-arrestin	IC	10206946	PubMed	PTHR11792:SF15	S-ARRESTIN
P00010	B cell activation	P00373	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00056	VEGF signaling pathway	P01404	SPK	HUMAN|HGNC=18859|UniProtKB=Q9NRA0	Sphingosine kinase 2	ISS			PTHR12358:SF40	SPHINGOSINE KINASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	IDA	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00021	FGF signaling pathway	P00627	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	10755300	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00048	PI3 kinase pathway	P01188	Gbetagamma	DANRE|ZFIN=ZDB-GENE-070112-342|UniProtKB=A1L271	Uncharacterized protein	ISS	1499560	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	PANTR|Ensembl=ENSPTRG00000001767|UniProtKB=G2HG81	Actin-related protein 2/3 complex subunit 5	ISS	9230079	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05915	Opioid proenkephalin pathway	P05992	met-Enkephalin	MACMU|Ensembl=ENSMMUG00000006775|UniProtKB=F7H3N8	Uncharacterized protein	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00010	B cell activation	P00371	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00049	Parkinson disease	P01236	Casein kinase II	ARATH|TAIR=AT3G60250|UniProtKB=O81275	Casein kinase II subunit beta-3	IDA	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P05918	p38 MAPK pathway	P06027	CREB	BOVIN|Gene=CREB1|UniProtKB=P27925	Cyclic AMP-responsive element-binding protein 1	ISS	11752053	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00558	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Ensembl=ENSGALG00000028896|UniProtKB=R4GMK5	Uncharacterized protein	IEP	89264452	PubMed	PTHR13140:SF728	MYOSIN HEAVY CHAIN, SKELETAL MUSCLE, ADULT
P00021	FGF signaling pathway	P00623	FGF	MACMU|Ensembl=ENSMMUG00000008668|UniProtKB=F7F3R0	Fibroblast growth factor	ISS			PTHR11486:SF41	FIBROBLAST GROWTH FACTOR 22
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=1765|UniProtKB=P55285	Cadherin-6	IDA	8120095	PubMed	PTHR24027:SF322	CADHERIN-6
P00036	Interleukin signaling pathway	P00990	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	RAT|RGD=2342|UniProtKB=P08482	Muscarinic acetylcholine receptor M1	IDA	8100450	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00047	PDGF signaling pathway	P01175	Shc	DROME|FlyBase=FBgn0015296|UniProtKB=Q9V3C8	DShc protein	ISS	8491186	PubMed	PTHR10337:SF11	DSHC PROTEIN
P00018	EGF receptor signaling pathway	P00560	Raf-1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P06002	G-protein	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00019	Endothelin signaling pathway	P00591	PLCbeta	ANOGA|Gene=AgaP_AGAP009115|UniProtKB=Q7PW25	Phosphoinositide phospholipase C (Fragment)	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00005	Angiogenesis	P00193	SOS-1	DICDI|dictyBase=DDB_G0284329|UniProtKB=Q54PQ4	Ras guanine nucleotide exchange factor A	ISS			PTHR23113:SF236	RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR A
P04393	Ras Pathway	P04567	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01089	VAChT	ANOGA|EnsemblGenome=AGAP002369|UniProtKB=Q7PR83	AGAP002369-PA	ISS	7938002	PubMed	PTHR23506:SF13	VESICULAR ACETYLCHOLINE TRANSPORTER
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	IXOSC|EnsemblGenome=ISCW009711|UniProtKB=B7Q3T6	THO complex subunit, putative	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00047	PDGF signaling pathway	P01159	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	HUMAN|HGNC=5978|UniProtKB=Q13261	Interleukin-15 receptor subunit alpha	IC			PTHR15060:SF0	INTERLEUKIN-15 RECEPTOR SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	MOUSE|MGI=MGI=96575|UniProtKB=P15208	Insulin receptor	TAS	14500580	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05754	Ggamma	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	YEAST|SGD=S000005738|UniProtKB=P18851	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00005	Angiogenesis	P00211	GSK3beta	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05918	p38 MAPK pathway	P06031	p38alpha	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04398	p53 pathway feedback loops 2	P04665	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00010	B cell activation	P00367	NFAT	HUMAN|HGNC=7776|UniProtKB=Q13469	Nuclear factor of activated T-cells, cytoplasmic 2	IDA	9133421	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00036	Interleukin signaling pathway	P00994	FKHRL1	HUMAN|HGNC=3821|UniProtKB=O43524	Forkhead box protein O3	IC	14775847	gi	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00005	Angiogenesis	P00193	SOS-1	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00052	TGF-beta signaling pathway	P01276	Co-Smads	RAT|RGD=3033|UniProtKB=O70437	Mothers against decapentaplegic homolog 4	TAS	9395284	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P00010	B cell activation	P00391	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01440	Cadherin	BOVIN|Ensembl=ENSBTAG00000014488|UniProtKB=E1BF53	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF91	CADHERIN-7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CANLF|Ensembl=ENSCAFG00000012181|UniProtKB=F2Z4N7	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	BOVIN|Ensembl=ENSBTAG00000007882|UniProtKB=G3X7Z2	Uncharacterized protein	ISS	14507926	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00036	Interleukin signaling pathway	P00990	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04609	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02750	Lipoate_biosynthesis	P03003	Lipoyl-protein ligase	ECOLI|EcoGene=EG11591|UniProtKB=P60720	Octanoyltransferase	ISS			PTHR10993:SF2	OCTANOYLTRANSFERASE
P00029	Huntington disease	P00777	CBP	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DANRE|ZFIN=ZDB-GENE-041001-104|UniProtKB=Q5TZD4	Protein kinase C	ISS	11880265	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00045	Notch signaling pathway	P01103	Next	DANRE|ZFIN=ZDB-GENE-011128-3|UniProtKB=Q5TZK8	Delta-like protein	IGI	9806913	PubMed	PTHR44097:SF1	PROTEIN JAGGED-2
P00046	Oxidative stress response	P01129	JNK1/2	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	TAS	8946915	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00021	FGF signaling pathway	P00629	PP2A	XENTR|Xenbase=XB-GENE-6076030|UniProtKB=F7DNP9	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B (Fragment)	ISS	7918404	PubMed	PTHR11871:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B GAMMA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00006	Apoptosis signaling pathway	P00313	IKK	HUMAN|HGNC=1974|UniProtKB=O15111	Inhibitor of nuclear factor kappa-B kinase subunit alpha	IDA	14499113	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00053	T cell activation	P01295	vav	HUMAN|HGNC=12657|UniProtKB=P15498	Proto-oncogene vav	IDA	10661401	PubMed	PTHR22826:SF112	PROTO-ONCOGENE VAV
P00048	PI3 kinase pathway	P01182	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	RAT|RGD=2917|UniProtKB=P15127	Insulin receptor	ISS	14500580	PubMed	PTHR24416:SF402	INSULIN RECEPTOR
P00049	Parkinson disease	P01208	Hsp70	MONDO|Ensembl=ENSMODG00000015173|UniProtKB=F6XFE0	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF223	HEAT SHOCK 70 KDA PROTEIN 1A-RELATED
P00005	Angiogenesis	P00190	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	8270251	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04393	Ras Pathway	P04557	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	ECOLI|EcoGene=EG10192|UniProtKB=P0ABK5	Cysteine synthase A	ISS			PTHR10314:SF159	CYSTEINE SYNTHASE A
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=88355|UniProtKB=P15116	Cadherin-2	IDA	13678586	PubMed	PTHR24027:SF79	CADHERIN-2
P00057	Wnt signaling pathway	P01465	Ggamma	MACMU|Ensembl=ENSMMUG00000014807|UniProtKB=F6W548	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00021	FGF signaling pathway	P00624	14-3-3	CAEBR|Gene=CBG17289|UniProtKB=A8XQR9	14-3-3 zeta	ISS	10407019	PubMed	PTHR18860:SF13	14-3-3 PROTEIN ZETA
P00005	Angiogenesis	P00206	Wnt	DROME|FlyBase=FBgn0010194|UniProtKB=P28466	Protein Wnt-5	ISS	8717036	PubMed	PTHR12027:SF77	PROTEIN WNT-5
P02752	Mannose metabolism	P03018	Mannose 1-P guanylyl transferase	MOUSE|MGI=MGI=1916330|UniProtKB=Q922H4	Mannose-1-phosphate guanyltransferase alpha	IEA	12477932	PubMed	PTHR22572:SF104	MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE ALPHA
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MACMU|Ensembl=ENSMMUG00000009980|UniProtKB=F6R3A1	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00049	Parkinson disease	P01215	Syntaxin	CAEBR|Gene=CBG12415|UniProtKB=A8XFD7	Protein CBR-SYX-7	ISS			PTHR19957:SF209	LD23667P
P00058	mRNA splicing	P01478	U2	MACMU|Ensembl=ENSMMUG00000014493|UniProtKB=F7GH69	U2 small nuclear ribonucleoprotein B	ISS	9716128	PubMed	PTHR10501:SF21	U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B''
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	IC	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00048	PI3 kinase pathway	P01192	p110	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DANRE|ZFIN=ZDB-GENE-041001-104|UniProtKB=Q5TZD4	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	PANTR|Ensembl=ENSPTRG00000017401|UniProtKB=H2R587	Casein kinase 1, alpha 1	ISS	10617630	PubMed	PTHR11909:SF84	CASEIN KINASE I ISOFORM ALPHA
P00012	Cadherin signaling pathway	P00474	Wnt	BRAFL|Gene=BRAFLDRAFT_118160|UniProtKB=C3Z2P0	Protein Wnt	IDA	11266476	PubMed	PTHR12027:SF77	PROTEIN WNT-5
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00059	p53 pathway	P04626	GADD45	MACMU|Ensembl=ENSMMUG00000014808|UniProtKB=F6W540	Growth arrest and DNA damage-inducible protein GADD45 alpha isoform 1	ISS	9827804	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DROME|FlyBase=FBgn0261854|UniProtKB=A1Z9X0	Atypical protein kinase C	ISS	3755548	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P04393	Ras Pathway	P04553	PAK	CHICK|Ensembl=ENSGALG00000008058|UniProtKB=F1N8W8	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00029	Huntington disease	P00790	beta-Tubulin	MOUSE|MGI=MGI=107814|UniProtKB=A2AQ07	Tubulin beta-1 chain	TAS	12932731	PubMed	PTHR11588:SF112	TUBULIN BETA-1 CHAIN
P00018	EGF receptor signaling pathway	P00550	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	8262390	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DANRE|ZFIN=ZDB-GENE-050410-4|UniProtKB=Q56A35	Actin-related protein 2-B	ISS	11889126	PubMed	PTHR11937:SF149	ACTIN-RELATED PROTEIN 2-A-RELATED
P04398	p53 pathway feedback loops 2	P04665	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=12784|UniProtKB=P41221	Protein Wnt-5a	IDA	8717036	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P02777	Succinate to proprionate conversion	P03161	Methylmalonyl-CoA mutase	CAEEL|WormBase=WBGene00014202|UniProtKB=Q23381	Probable methylmalonyl-CoA mutase, mitochondrial	ISS			PTHR42710:SF1	METHYLMALONYL-COA MUTASE, MITOCHONDRIAL
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00046	Oxidative stress response	P01137	MNK1/2	BOVIN|Gene=MKNK1|UniProtKB=Q58D94	MAP kinase-interacting serine/threonine-protein kinase 1	ISS	11575158	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00005	Angiogenesis	P00256	PLC-gamma	CANLF|Ensembl=ENSCAFG00000019989|UniProtKB=E2RQM0	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00059	p53 pathway	P04623	CBP	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	IDA	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00047	PDGF signaling pathway	P01152	RasGAP	MACMU|Ensembl=ENSMMUG00000009418|UniProtKB=F6X9K0	Uncharacterized protein	ISS	20475167	gi	PTHR10194:SF21	RAS GTPASE-ACTIVATING PROTEIN 2
P04393	Ras Pathway	P04558	p38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P02731	Biotin biosynthesis	P02857	Biotin synthase	THEMA|EnsemblGenome=THEMA_07990|UniProtKB=Q9X0Z6	[FeFe] hydrogenase maturase subunit HydE	ISS			PTHR43726:SF1	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05918	p38 MAPK pathway	P06016	HSP27	MACMU|Ensembl=ENSMMUG00000004124|UniProtKB=F6XTF7	Heat shock protein beta-1	ISS	8280084	PubMed	PTHR11527:SF114	HEAT SHOCK PROTEIN BETA-1
P00060	Ubiquitin proteasome pathway	P01491	E2	RAT|RGD=1359534|UniProtKB=Q6AXR9	Protein Ube2a	ISS			PTHR43898:SF4	UBIQUITIN-CONJUGATING ENZYME E2 A
P00060	Ubiquitin proteasome pathway	P01491	E2	BOVIN|Ensembl=ENSBTAG00000020175|UniProtKB=P61085	Ubiquitin-conjugating enzyme E2 K	ISS			PTHR44020:SF2	UBIQUITIN-CONJUGATING ENZYME E2 K
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	9658176	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00029	Huntington disease	P00778	NMDA receptor	CANLF|Ensembl=ENSCAFG00000013148|UniProtKB=Q5R1P3	Glutamate receptor ionotropic, NMDA 2B	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MOUSE|MGI=MGI=1309999|UniProtKB=Q922R0	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	HUMAN|HGNC=145|UniProtKB=P63267	Actin, gamma-enteric smooth muscle	IEP	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00021	FGF signaling pathway	P00648	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	BOVIN|Ensembl=ENSBTAG00000045943|UniProtKB=P13536	Acetylcholine receptor subunit gamma	IC	95224005	PubMed	PTHR18945:SF60	ACETYLCHOLINE RECEPTOR SUBUNIT GAMMA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00005	Angiogenesis	P00182	p38MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05915	Opioid proenkephalin pathway	P05994	G-protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	XENTR|Xenbase=XB-GENE-969601|UniProtKB=Q28H40	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00001	Adrenaline and noradrenaline biosynthesis	P00068	amine translocator	DROME|FlyBase=FBgn0029663|UniProtKB=B7Z122	Transporter	IC	12719981	PubMed	PTHR11616:SF182	TRANSPORTER
P00006	Apoptosis signaling pathway	P00274	JNK	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	ISS	10207617	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04393	Ras Pathway	P04559	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00047	PDGF signaling pathway	P01154	Ras	CAEEL|WormBase=WBGene00008671|UniProtKB=O17788	Uncharacterized protein	ISS			PTHR24073:SF354	RAS-RELATED PROTEIN RAB-2A
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	MACMU|Ensembl=ENSMMUG00000010173|UniProtKB=F7AGU8	Presenilin	ISS	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00048	PI3 kinase pathway	P01185	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	8188688	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00009	Axon guidance mediated by netrin	P00366	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_56687|UniProtKB=C3YC50	Putative uncharacterized protein	IDA	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	PANTR|Ensembl=ENSPTRG00000007084|UniProtKB=H2Q9G5	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	HUMAN|HGNC=6693|UniProtKB=Q9NZR2	Low-density lipoprotein receptor-related protein 1B	IDA	11907044	PubMed	PTHR44025:SF7	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	HUMAN|HGNC=4597|UniProtKB=P41594	Metabotropic glutamate receptor 5	ISS	7476890	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	CAEEL|WormBase=WBGene00000068|UniProtKB=Q19523	Adenylyl CYclase	IDA	22013858	PubMed	PTHR11920:SF319	ADENYLATE CYCLASE TYPE 9
P00053	T cell activation	P01320	PLC-gamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CHICK|Ensembl=ENSGALG00000008898|UniProtKB=F1P2J9	Uncharacterized protein	IC	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	RAT|RGD=2740|UniProtKB=Q62645	Glutamate receptor ionotropic, NMDA 2D	IC	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2D.html	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IDA	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00057	Wnt signaling pathway	P01444	Wnt	TAKRU|Ensembl=ENSTRUG00000016522|UniProtKB=H2UZ46	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	BOVIN|Ensembl=ENSBTAG00000039772|UniProtKB=F6QI78	Uncharacterized protein	ISS	8143856	PubMed	PTHR24247:SF31	5-HYDROXYTRYPTAMINE RECEPTOR 2B
P02783	Tryptophan biosynthesis	P03206	Anthranilate synthase	METAC|EnsemblGenome=MA_2986|UniProtKB=Q8TLP8	Anthranilate synthase, component II	RCA			PTHR43418:SF4	MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00029	Huntington disease	P00785	Cytochrome c	BOVIN|Ensembl=ENSBTAG00000012232|UniProtKB=P00125	Cytochrome c1, heme protein, mitochondrial	ISS	15163634	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00017	DNA replication	P00538	RNase H	ECOLI|EcoGene=EG10860|UniProtKB=P0A7Y4	Ribonuclease HI	ISS	21534947	PubMed	PTHR10642:SF0	RIBONUCLEASE H1
P05918	p38 MAPK pathway	P06031	p38alpha	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00557	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04665	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04397	p53 pathway by glucose deprivation	P04645	TSC1	RAT|RGD=620124|UniProtKB=Q9Z136	Hamartin	ISS	12820960	PubMed	PTHR15154:SF2	HAMARTIN
P00029	Huntington disease	P00807	Actin	USTMA|Gene=UMAG_11232|UniProtKB=A0A0D1DMT3	Chromosome 22, whole genome shotgun sequence	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00021	FGF signaling pathway	P00629	PP2A	PHYPA|Gene=PHYPADRAFT_226377|UniProtKB=A9TXC9	Serine/threonine-protein phosphatase	ISS			PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	IDA	3755548	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MOUSE|MGI=MGI=99675|UniProtKB=Q8VHH7	Adenylate cyclase type 3	ISS	2491850	PubMed	PTHR11920:SF291	ADENYLATE CYCLASE TYPE 3
P05913	Enkephalin release	P05974	G-Protein (i)	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IDA	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00877	MLCK	HUMAN|HGNC=29826|UniProtKB=Q32MK0	Myosin light chain kinase 3	IDA	600922	OMIM	PTHR45411:SF1	MYOSIN LIGHT CHAIN KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	IDA	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00006	Apoptosis signaling pathway	P00289	FAS	MACMU|Gene=FAS|UniProtKB=Q9BDP2	Tumor necrosis factor receptor superfamily member 6	ISS	10327065	PubMed	PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P04398	p53 pathway feedback loops 2	P04665	AKT	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00273	p53	MACMU|Ensembl=ENSMMUG00000008639|UniProtKB=P56424	Cellular tumor antigen p53	ISS	11313951	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00906	Rap1	MOUSE|MGI=MGI=894315|UniProtKB=Q99JI6	Ras-related protein Rap-1b	ISS	1904317	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00402	Jnk	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00018	EGF receptor signaling pathway	P00539	14-3-3	SCHMA|EnsemblGenome=Smp_009760|UniProtKB=G4LUI9	14-3-3 protein, putative	IGI	96123403	PubMed	PTHR18860:SF13	14-3-3 PROTEIN ZETA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	11847220	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04398	p53 pathway feedback loops 2	P04657	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	DICDI|dictyBase=DDB_G0277143|UniProtKB=P36408	Guanine nucleotide-binding protein subunit beta	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00034	Integrin signalling pathway	P00947	Laminin	RAT|Ensembl=ENSRNOG00000059507|UniProtKB=A0A0G2K023	Protein Lamc3	ISS	2538453	PubMed	PTHR10574:SF240	LAMININ SUBUNIT GAMMA-3
P00006	Apoptosis signaling pathway	P00318	PKCs	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00019	Endothelin signaling pathway	P00589	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00012	Cadherin signaling pathway	P00475	Frizzled	PANTR|Ensembl=ENSPTRG00000020490|UniProtKB=H2R2C6	Frizzled homolog 6	ISS	8717036	PubMed	PTHR11309:SF75	FRIZZLED-6
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95818|UniProtKB=Q61626	Glutamate receptor ionotropic, kainate 5	ISS	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00036	Interleukin signaling pathway	P00985	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00566	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IGI	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01304	Csk	PANTR|Ensembl=ENSPTRG00000007282|UniProtKB=H2Q9T1	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MOUSE|MGI=MGI=1913316|UniProtKB=P61953	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	ISS			PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P00005	Angiogenesis	P00230	PDGFR	XENTR|Xenbase=XB-GENE-6072920|UniProtKB=F6RSC1	Platelet-derived growth factor receptor alpha	ISS			PTHR24416:SF52	PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	8649368	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	ARATH|TAIR=AT5G12200|UniProtKB=Q9FMP3	Dihydropyrimidinase	IEA	9501997	PubMed	PTHR11647:SF1	COLLAPSIN RESPONSE MEDIATOR PROTEIN
P00005	Angiogenesis	P00203	Erk	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05915	Opioid proenkephalin pathway	P05988	peptide E	MACMU|Ensembl=ENSMMUG00000006775|UniProtKB=F7H3N8	Uncharacterized protein	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	DICDI|dictyBase=DDB_G0283907|UniProtKB=P34099	cAMP-dependent protein kinase catalytic subunit	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00005	Angiogenesis	P00252	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	RAT|RGD=628852|UniProtKB=Q02294	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	8386525	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00036	Interleukin signaling pathway	P00990	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00015	Circadian clock system	P00504	Per	MACMU|Ensembl=ENSMMUG00000018562|UniProtKB=F6YMC9	Uncharacterized protein	ISS	15700718	PubMed	PTHR11269:SF13	PERIOD CIRCADIAN PROTEIN HOMOLOG 3
P00010	B cell activation	P00376	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00021	FGF signaling pathway	P00626	Spry	RAT|RGD=1305324|UniProtKB=D3ZJA3	Protein Spry4	ISS	99264295	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00057	Wnt signaling pathway	P01451	Galpha	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	IDA	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00010	B cell activation	P00381	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01331	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IDA	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	MONDO|Ensembl=ENSMODG00000001807|UniProtKB=F6Y7R9	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00021	FGF signaling pathway	P00648	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	90172230	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01438	PP2A	MOUSE|MGI=MGI=1321161|UniProtKB=P62715	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P02742	Tetrahydrofolate biosynthesis	P02951	GTP cyclohydrolase	PSEAE|EnsemblGenome=PA3438|UniProtKB=Q9HYG8	GTP cyclohydrolase 1 1	ISS			PTHR11109:SF0	GTP CYCLOHYDROLASE 1
P00029	Huntington disease	P00781	Dynactin	RAT|RGD=62038|UniProtKB=P28023	Dynactin subunit 1	IPI	9454836	PubMed	PTHR18916:SF40	DYNACTIN SUBUNIT 1
P00049	Parkinson disease	P01239	Cul-1	EMENI|EnsemblGenome=CADANIAG00001628|UniProtKB=C8VU45	SCF ubiquitin ligase complex subunit CulA, putative (AFU_orthologue AFUA_1G12960)	IDA	12628165	PubMed	PTHR11932:SF81	CULLIN-1
P00021	FGF signaling pathway	P00634	MEKK1-5	MACMU|Ensembl=ENSMMUG00000016751|UniProtKB=F7AIB6	Mitogen-activated protein kinase kinase kinase 3 isoform 1	ISS	9006902	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00046	Oxidative stress response	P01135	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	TAS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00057	Wnt signaling pathway	P01457	GBeta	BRAFL|Gene=BRAFLDRAFT_220697|UniProtKB=C3ZSF0	Putative uncharacterized protein	ISS	9740024	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P05912	Dopamine receptor mediated signaling pathway	P05963	MAO	HUMAN|HGNC=6834|UniProtKB=P27338	Amine oxidase [flavin-containing] B	ISS	90344230	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P00036	Interleukin signaling pathway	P00983	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00363	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00471	Cadherin	DANRE|ZFIN=ZDB-GENE-980526-242|UniProtKB=F1REQ8	Uncharacterized protein	IDA	8120095	PubMed	PTHR24028:SF96	SUBFAMILY NOT NAMED
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	RAT|RGD=1305752|UniProtKB=Q4FZT9	26S proteasome non-ATPase regulatory subunit 2	ISS			PTHR10943:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IDA	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MACMU|Ensembl=ENSMMUG00000004250|UniProtKB=F6YVM2	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF32	MACROPHAGE METALLOELASTASE
P00012	Cadherin signaling pathway	P00470	F-actin	RAT|RGD=1309504|UniProtKB=D3ZRN3	Protein Actbl2	ISS	3487386	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00010	B cell activation	P00401	jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	TAKRU|Ensembl=ENSTRUG00000007478|UniProtKB=H2T1I6	Uncharacterized protein	ISS	12888804	PubMed	PTHR43940:SF5	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ORYSJ|EnsemblGenome=OS06G0699400|UniProtKB=Q5Z859	Mitogen-activated protein kinase 4	ISS	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P05918	p38 MAPK pathway	P06015	p38gamma	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	HUMAN|HGNC=290|UniProtKB=P35626	Beta-adrenergic receptor kinase 2	IDA	8288567	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P00049	Parkinson disease	G01547	DAT	HUMAN|HGNC=11049|UniProtKB=Q01959	Sodium-dependent dopamine transporter	ISS	15135042	PubMed	PTHR11616:SF38	SODIUM-DEPENDENT DOPAMINE TRANSPORTER
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	IDA	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00029	Huntington disease	P00790	beta-Tubulin	ORYSJ|EnsemblGenome=OS03G0105600|UniProtKB=Q8H7U1	Tubulin beta-2 chain	TAS	9454836	PubMed	PTHR11588:SF178	TUBULIN BETA-7 CHAIN
P00034	Integrin signalling pathway	P00948	Rho	CAEEL|WormBase=WBGene00004357|UniProtKB=Q22038	Ras-like GTP-binding protein rhoA	IGI	11973360	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00034	Integrin signalling pathway	P00941	Integrin alpha	PANTR|Ensembl=ENSPTRG00000009387|UniProtKB=H2QDE3	Uncharacterized protein	ISS	3487386	PubMed	PTHR23220:SF89	INTEGRIN ALPHA-3
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MOUSE|MGI=MGI=1929866|UniProtKB=Q9QZB1	Regulator of G-protein signaling 20	IDA	8756726	PubMed	PTHR10845:SF175	REGULATOR OF G-PROTEIN SIGNALING 20
P02787	Vitamin B6 metabolism	P03227	Phosphoserine transaminase	YEAST|SGD=S000005710|UniProtKB=P33330	Phosphoserine aminotransferase	TAS	9169874	PubMed	PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P04393	Ras Pathway	P04563	Ets	MACMU|Ensembl=ENSMMUG00000020706|UniProtKB=F6PU72	Uncharacterized protein	ISS	15699632	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00024	Glycolysis	P00674	Phosphoglucose isomerase	ORYSJ|Gene=Os06g0256500|UniProtKB=P42863	Glucose-6-phosphate isomerase, cytosolic B	ISS	96293857	PubMed	PTHR11469:SF1	GLUCOSE-6-PHOSPHATE ISOMERASE, CYTOSOLIC
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	ARATH|TAIR=AT2G30910|UniProtKB=O80856	Actin-related protein 2/3 complex subunit 1A	ISS	12932731	PubMed	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P00024	Glycolysis	P00679	Aldolase	MOUSE|MGI=MGI=1931052|UniProtKB=A6ZI47	Fructose-bisphosphate aldolase	ISS	74094688	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00047	PDGF signaling pathway	P01174	Rho	MOUSE|MGI=MGI=1916903|UniProtKB=A2AB59	Rho GTPase-activating protein 27	ISS	8288572	PubMed	PTHR23181:SF2	RHO GTPASE-ACTIVATING PROTEIN 27
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=2136752|UniProtKB=Q91Y03	MCG141291	IDA	8120095	PubMed	PTHR24028:SF61	PROTOCADHERIN BETA-13
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00018	EGF receptor signaling pathway	P00547	PP2A	CANLF|Ensembl=ENSCAFG00000014047|UniProtKB=F1PV54	Uncharacterized protein	ISS	96161994	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00572	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00021	FGF signaling pathway	P00628	JNK1-3	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00047	PDGF signaling pathway	P01171	PLCgamma	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00778	NMDA receptor	BOVIN|Ensembl=ENSBTAG00000000219|UniProtKB=F1MCL3	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2522|UniProtKB=P30729	D(4) dopamine receptor	IDA	12181435	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00057	Wnt signaling pathway	P01435	SWI/SNF	TAKRU|Ensembl=ENSTRUG00000018409|UniProtKB=H2VD11	Uncharacterized protein	ISS	11532957	PubMed	PTHR13844:SF1	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D MEMBER 1
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	CANLF|Ensembl=ENSCAFG00000023687|UniProtKB=F1PCC1	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF63	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	HUMAN|HGNC=6153|UniProtKB=P05556	Integrin beta-1	IDA	10706722	PubMed	PTHR10082:SF28	INTEGRIN BETA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00255	Notch	CANLF|Ensembl=ENSCAFG00000010476|UniProtKB=F1PS94	Uncharacterized protein	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P04393	Ras Pathway	P04558	p38	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P05731	GABA-B receptor II signaling	P05752	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MOUSE|MGI=MGI=87902|UniProtKB=P68134	Actin, alpha skeletal muscle	ISS	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00060	Ubiquitin proteasome pathway	P01490	E3	MONDO|Ensembl=ENSMODG00000005239|UniProtKB=F6YN15	Uncharacterized protein	ISS			PTHR11254:SF357	UBIQUITIN-PROTEIN LIGASE E3C
P00029	Huntington disease	P00778	NMDA receptor	MOUSE|MGI=MGI=95819|UniProtKB=P35438	Glutamate receptor ionotropic, NMDA 1	IDA	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00056	VEGF signaling pathway	P01425	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MOUSE|MGI=MGI=1859709|UniProtKB=P97492	Regulator of G-protein signaling 14	IDA	10779778	PubMed	PTHR10845:SF179	REGULATOR OF G-PROTEIN SIGNALING 14
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	IC	15313841	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00008	Axon guidance mediated by Slit/Robo	P00355	Rho	PANTR|Ensembl=ENSPTRG00000001112|UniProtKB=H2PZP2	Ras homolog gene family, member C	ISS	12090470	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P02738	De novo purine biosynthesis	P02902	ADP reductase	BACSU|EnsemblGenome=BSU17380|UniProtKB=P50620	Ribonucleoside-diphosphate reductase subunit alpha	ISS			PTHR11573:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	12657601	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01095	beta	MOUSE|MGI=MGI=87891|UniProtKB=Q9ERK7	Neuronal acetylcholine receptor subunit beta-2	ISS	22213672	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P00034	Integrin signalling pathway	P00907	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	XENTR|Xenbase=XB-GENE-482228|UniProtKB=F6RYL1	Uncharacterized protein	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06801	NAB	MOUSE|MGI=MGI=107563|UniProtKB=Q61127	NGFI-A-binding protein 2	RCA			PTHR12623:SF6	NGFI-A-BINDING PROTEIN 2
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01143	ERK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00021	FGF signaling pathway	P00644	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00034	Integrin signalling pathway	P00925	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	HUMAN|HGNC=10940|UniProtKB=P43004	Excitatory amino acid transporter 2	IC	94365697	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P00010	B cell activation	P00379	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IPI	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CHICK|Gene=CHRNA2|UniProtKB=P09480	Neuronal acetylcholine receptor subunit alpha-2	IC			PTHR18945:SF757	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02788	Xanthine and guanine salvage pathway	P03245	Guanine phosphoribosyl transferase	TRYB2|Gene=Tb10.70.6650|UniProtKB=Q38CA0	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PHYPA|Gene=PHYPADRAFT_226658|UniProtKB=A9TYG3	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00053	T cell activation	P01336	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IGI	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02723	Adenine and hypoxanthine salvage pathway	P02805	Adenine phosphorylase	HUMAN|HGNC=7892|UniProtKB=P00491	Purine nucleoside phosphorylase	ISS			PTHR11904:SF12	PURINE NUCLEOSIDE PHOSPHORYLASE
P00057	Wnt signaling pathway	P01444	Wnt	MACMU|Ensembl=ENSMMUG00000015709|UniProtKB=F6SLX4	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05913	Enkephalin release	P05977	G-Protein (s)	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF31	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01200	SHIP	PANTR|Ensembl=ENSPTRG00000004031|UniProtKB=H2Q4C6	Inositol polyphosphate phosphatase-like 1	ISS	12145149	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P02738	De novo purine biosynthesis	P02891	GDP kinase	DANRE|ZFIN=ZDB-GENE-000210-35|UniProtKB=F1QQX1	Nucleoside diphosphate kinase	ISS			PTHR43109:SF2	NUCLEOSIDE DIPHOSPHATE KINASE 7
P00020	FAS signaling pathway	P00604	Pro-Caspase8	PANTR|Ensembl=ENSPTRG00000012801|UniProtKB=H2QJ86	Caspase 8, apoptosis-related cysteine peptidase	ISS	11917123	PubMed	PTHR10454:SF162	CASPASE-8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	11554554	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00048	PI3 kinase pathway	P01185	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Ensembl=ENSPTRG00000018449|UniProtKB=H2QTG5	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05730	Endogenous cannabinoid signaling	P05748	mGluR	PANTR|Ensembl=ENSPTRG00000018684|UniProtKB=C7G3M7	Glutamate receptor, metabotropic 1	ISS	12351712	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00024	Glycolysis	P00679	Aldolase	MOUSE|MGI=MGI=2447811|UniProtKB=A6ZI46	Fructose-bisphosphate aldolase	ISS	84261525	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	CHICK|Gene=CHRNA5|UniProtKB=P26152	Neuronal acetylcholine receptor subunit alpha-5	ISS	85270494	PubMed	PTHR18945:SF76	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12805548	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IDA	91298951	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00547	PP2A	BOVIN|Ensembl=ENSBTAG00000007061|UniProtKB=Q08DP7	Protein phosphatase 2, regulatory subunit B', beta isoform	ISS	11531413	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT4G36450|UniProtKB=O23236	Mitogen-activated protein kinase 14	ISS	10514528	PubMed	PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P00048	PI3 kinase pathway	P01179	PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06009	K+ channel	PANTR|Ensembl=ENSPTRG00000020614|UniProtKB=H2QWR7	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PHANO|EnsemblGenome=SNOG_01139|UniProtKB=H2KNE6	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P02781	Threonine biosynthesis	P03189	Aspartate kinase	ARATH|TAIR=AT5G14060|UniProtKB=O23653	Aspartokinase 2, chloroplastic	ISS			PTHR21499:SF47	ASPARTOKINASE 2, CHLOROPLASTIC-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	PANTR|Ensembl=ENSPTRG00000013902|UniProtKB=H2RCL0	Uncharacterized protein	ISS			PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P00035	Interferon-gamma signaling pathway	P00957	IFNGR2	MOUSE|MGI=MGI=107654|UniProtKB=Q63953	Ifngr2 protein	TAS	10679118	PubMed	PTHR20859:SF46	INTERFERON GAMMA RECEPTOR 2
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05915	Opioid proenkephalin pathway	P05991	Enkephalin	RAT|RGD=62054|UniProtKB=P06300	Proenkephalin-B	ISS	131330	OMIM	PTHR11438:SF4	PROENKEPHALIN-B
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000024992|UniProtKB=F6TUR3	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00047	PDGF signaling pathway	P01156	PDGF receptor B	PANTR|Ensembl=ENSPTRG00000020022|UniProtKB=H2QVT0	Platelet-derived growth factor receptor-like	ISS			PTHR15360:SF1	PLATELET-DERIVED GROWTH FACTOR RECEPTOR-LIKE PROTEIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	DROME|FlyBase=FBgn0032151|UniProtKB=Q7KTF8	Nicotinic acetylcholine receptor alpha6, isoform E	ISS	11404397	PubMed	PTHR18945:SF763	NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA6, ISOFORM E
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	ORYSJ|EnsemblGenome=OS07G0694000|UniProtKB=Q6Z3Y9	Phosphoinositide phospholipase C	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P02738	De novo purine biosynthesis	P02908	Phosphoribosylamine glycine ligase	ANOGA|EnsemblGenome=AGAP009786|UniProtKB=Q7Q1H5	AGAP009786-PA	ISS			PTHR10520:SF10	TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3
P02785	Valine biosynthesis	P03217	Dihydroxy isovalerate reductoisomerase	GLOVI|EnsemblGenome=BAC90598|UniProtKB=Q7NH80	Ketol-acid reductoisomerase	ISS			PTHR21371:SF1	KETOL-ACID REDUCTOISOMERASE, CHLOROPLASTIC
P02738	De novo purine biosynthesis	P02909	GDP reductase	HALSA|EnsemblGenome=VNG_2383G|UniProtKB=Q9HMU4	Ribonucleoside reductase small chain	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P05913	Enkephalin release	G06045	preproenkephalin	XENTR|Xenbase=XB-GENE-942760|UniProtKB=F6Y5F6	Uncharacterized protein	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00927	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	HUMAN|HGNC=1076|UniProtKB=P36894	Bone morphogenetic protein receptor type-1A	IDA			PTHR23255:SF50	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	ISS	10553940	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	YEAST|SGD=S000001550|UniProtKB=P36010	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00047	PDGF signaling pathway	P01171	PLCgamma	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	MOUSE|MGI=MGI=2384786|UniProtKB=Q91XE9	Cyclic AMP-responsive element-binding protein 3-like protein 3	ISS	1354612	PubMed	PTHR22952:SF98	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 3
P00059	p53 pathway	G01571	FAS	MACMU|Gene=FAS|UniProtKB=Q9BDP2	Tumor necrosis factor receptor superfamily member 6	IGI	10327065	PubMed	PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00892	Grb2	DANRE|ZFIN=ZDB-GENE-040426-1975|UniProtKB=Q6PC73	Growth factor receptor-bound protein 2	ISS	8479536	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00038	JAK/STAT signaling pathway	P01031	PIAS	MOUSE|MGI=MGI=1096566|UniProtKB=Q8C5D8	E3 SUMO-protein ligase PIAS2	ISS	8682149	PubMed	PTHR10782:SF12	E3 SUMO-PROTEIN LIGASE PIAS2
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MACMU|Ensembl=ENSMMUG00000009778|UniProtKB=F6Y1M7	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF385	MYOSIN-2
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	TAS	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00038	JAK/STAT signaling pathway	P01027	STAT	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01208	Hsp70	CAEEL|WormBase=WBGene00002010|UniProtKB=P11141	Heat shock 70 kDa protein F, mitochondrial	IDA	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	ARATH|TAIR=AT4G20890|UniProtKB=P29517	Tubulin beta-9 chain	ISS	9454836	PubMed	PTHR11588:SF245	TUBULIN BETA-4 CHAIN-RELATED
P00049	Parkinson disease	P01223	UbcH8	CAEEL|WormBase=WBGene00006713|UniProtKB=Q21633	UBiquitin Conjugating enzyme	IDA			PTHR24068:SF116	AT26201P-RELATED
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MOUSE|MGI=MGI=1927469|UniProtKB=Q9QZB0	Regulator of G-protein signaling 17	IDA	21240406	PubMed	PTHR10845:SF196	REGULATOR OF G-PROTEIN SIGNALING 17
P00018	EGF receptor signaling pathway	P00558	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00029	Huntington disease	P00799	JNK-2	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ARATH|TAIR=AT3G46520|UniProtKB=P53497	Actin-12	IC	10974003	PubMed	PTHR11937:SF276	ACTIN-12
P00021	FGF signaling pathway	P00642	MEK1-2	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00005	Angiogenesis	P00206	Wnt	RAT|RGD=1311441|UniProtKB=A0A0G2K3B7	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	ARATH|TAIR=AT5G07880|UniProtKB=Q9SD96	SNAP25 homologous protein SNAP29	IC			PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00049	Parkinson disease	P01238	14-3-3	SCHMA|EnsemblGenome=Smp_002410|UniProtKB=Q95W36	14-3-3 epsilon 2	IDA	12062487	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P02759	Pyridoxal-5-phosphate biosynthesis	P03062	1-Deoxyxylulose-5-phosphate synthase	ARATH|TAIR=AT5G11380|UniProtKB=Q9LFL9	1-D-deoxyxylulose 5-phosphate synthase-like protein	ISS			PTHR43322:SF3	1-D-DEOXYXYLULOSE 5-PHOSPHATE SYNTHASE-LIKE PROTEIN
P00012	Cadherin signaling pathway	P00462	Casein kinase II	DAPPU|EnsemblGenome=DAPPUDRAFT_223674|UniProtKB=E9GCV0	Putative uncharacterized protein	ISS	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CANLF|Gene=GRIN1|UniProtKB=Q5R1P0	Glutamate receptor ionotropic, NMDA 1	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00021	FGF signaling pathway	P00641	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	IDA	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CHICK|Ensembl=ENSGALG00000005396|UniProtKB=Q2LMP1	Protein Wnt-3a	TAS	11266476	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00010	B cell activation	P00379	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00052	TGF-beta signaling pathway	P01275	P38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00053	T cell activation	P01311	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	DROME|FlyBase=FBgn0002842|UniProtKB=Q9VP40	Spermatocyte arrest	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IDA	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00056	VEGF signaling pathway	P01407	Erk	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	9298898	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00015	Circadian clock system	G01497	cry	HUMAN|HGNC=2384|UniProtKB=Q16526	Cryptochrome-1	IEP	10428031	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00047	PDGF signaling pathway	P01159	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00036	Interleukin signaling pathway	P00966	mTOR	MACMU|Ensembl=ENSMMUG00000019325|UniProtKB=F6RVV5	Uncharacterized protein	ISS	7518356	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	TAS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P02746	Heme biosynthesis	P02982	Protoheme IX farnesyl transferase	DEIRA|EnsemblGenome=DR_2618|UniProtKB=Q9RR78	Protoheme IX farnesyltransferase	ISS			PTHR43448:SF2	PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00005	Angiogenesis	P00249	PAK	CANLF|Ensembl=ENSCAFG00000004956|UniProtKB=E2REH3	Uncharacterized protein	ISS	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01332	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00019	Endothelin signaling pathway	P00568	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IGI	10644715	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00021	FGF signaling pathway	P00644	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	CANLF|Ensembl=ENSCAFG00000006453|UniProtKB=F6X958	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00944	Actin	ORNAN|Ensembl=ENSOANG00000007716|UniProtKB=F6UDX9	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CHICK|Ensembl=ENSGALG00000005401|UniProtKB=Q3L251	Protein Wnt	TAS	8717036	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02916	dTMP kinase	DEIRA|EnsemblGenome=DR_0111|UniProtKB=Q9RY40	Thymidylate kinase	ISS			PTHR10344:SF1	THYMIDYLATE KINASE
P02782	Triacylglycerol metabolism	P03205	Triacylglycerol lipase	CAEEL|WormBase=WBGene00016704|UniProtKB=Q966P1	Uncharacterized protein	ISS			PTHR23025:SF3	HORMONE-SENSITIVE LIPASE
P00047	PDGF signaling pathway	P01152	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00148	Erb-B4 N-terminal fragment	ORNAN|Ensembl=ENSOANG00000007021|UniProtKB=F7GAV2	Receptor protein-tyrosine kinase	ISS	11067415	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	MONDO|Ensembl=ENSMODG00000023683|UniProtKB=F6T0L6	Uncharacterized protein (Fragment)	ISS	15328036	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	RCA	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000008826|UniProtKB=F6XUU0	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00807	Actin	DROME|FlyBase=FBgn0000042|UniProtKB=P10987	Actin-5C	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	TAS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04395	Vasopressin synthesis	P04599	Amidating Enzyme	MACMU|Ensembl=ENSMMUG00000007844|UniProtKB=F7BDY1	Uncharacterized protein	ISS	3153462	PubMed	PTHR10680:SF14	PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00776	c-Jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	ANOGA|EnsemblGenome=AGAP001506|UniProtKB=Q7PXP3	AGAP001506-PA	IC			PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ORYSJ|EnsemblGenome=OS05G0438800|UniProtKB=Q75HX0	Actin	IC	11889126	PubMed	PTHR11937:SF248	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00807	Actin	CAEBR|Gene=CBG02161|UniProtKB=A8WS32	Protein CBG02161	ISS	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00029	Huntington disease	P00799	JNK-2	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00046	Oxidative stress response	P01129	JNK1/2	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00049	Parkinson disease	P01230	Src kinase	RAT|RGD=621319|UniProtKB=Q6P6U0	Tyrosine-protein kinase Fgr	IDA	11078745	PubMed	PTHR24418:SF224	TYROSINE-PROTEIN KINASE FGR
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00048	PI3 kinase pathway	P01181	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00029	Huntington disease	P00805	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	STRPU|EnsemblGenome=SPU_003894|UniProtKB=W4XKG7	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF155	TUBULIN BETA-2 CHAIN
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	PANTR|Ensembl=ENSPTRG00000020122|UniProtKB=H2QVZ0	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF22	FRIZZLED-3
P00034	Integrin signalling pathway	P00907	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02751	Lysine biosynthesis	P03008	Dihydrodipicolinate synthase	CHLTR|EnsemblGenome=CT_361|UniProtKB=O84366	4-hydroxy-tetrahydrodipicolinate synthase	ISS			PTHR12128:SF15	4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	ARATH|TAIR=AT5G04510|UniProtKB=Q9XF67	3-phosphoinositide-dependent protein kinase 1	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P05913	Enkephalin release	P05977	G-Protein (s)	PANTR|Ensembl=ENSPTRG00000006342|UniProtKB=H2Q8A8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00049	Parkinson disease	P01208	Hsp70	TRIVA|Gene=TVAG_206270|UniProtKB=A2E1L2	Cytosolic heat shock protein 70, putative	IDA	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00057	Wnt signaling pathway	P01451	Galpha	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	IDA	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00012	Cadherin signaling pathway	P00468	Src	HUMAN|HGNC=11283|UniProtKB=P12931	Proto-oncogene tyrosine-protein kinase Src	ISS	11078745	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00633	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	ORYSJ|EnsemblGenome=OS01G0807900|UniProtKB=Q94J90	Os01g0807900 protein	IEA	12447438	PubMed	PTHR11647:SF1	COLLAPSIN RESPONSE MEDIATOR PROTEIN
P04397	p53 pathway by glucose deprivation	P04640	p53	HUMAN|HGNC=12003|UniProtKB=O15350	Tumor protein p73	TAS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	BOVIN|Ensembl=ENSBTAG00000014674|UniProtKB=P41985	Muscarinic acetylcholine receptor M2	ISS			PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P04398	p53 pathway feedback loops 2	P04666	cyclin A	MACMU|Ensembl=ENSMMUG00000001178|UniProtKB=F6RGI5	Uncharacterized protein	RCA			PTHR10177:SF254	CYCLIN-A1
P00005	Angiogenesis	P00206	Wnt	PANTR|Ensembl=ENSPTRG00000004892|UniProtKB=H2Q5U3	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P04395	Vasopressin synthesis	P04589	Signal Peptidase	NEUCR|EnsemblGenome=EFNCRG00000005142|UniProtKB=Q7RY44	Signal peptidase complex catalytic subunit sec11	IC	2092035	PubMed	PTHR10806:SF6	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11
P00053	T cell activation	P01332	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04371	5-Hydroxytryptamine biosynthesis	P04400	Aromatic L-amino acid decarboxylase	CAEBR|Gene=CBG08967|UniProtKB=A8X844	Protein CBR-BAS-1	ISS	90339966	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P02769	Purine metabolism	P03115	Nucleoside Phosphorylase	BOVIN|Ensembl=ENSBTAG00000012317|UniProtKB=P55859	Purine nucleoside phosphorylase	TAS	9585525	PubMed	PTHR11904:SF12	PURINE NUCLEOSIDE PHOSPHORYLASE
P00013	Cell cycle	P00480	Proteasome	TRYB2|Gene=Tb10.70.6360|UniProtKB=Q38C86	Proteasome regulatory non-ATP-ase subunit 5	ISS	21975205	PubMed	PTHR10855:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12
P00047	PDGF signaling pathway	P01165	SRF	RAT|RGD=1559787|UniProtKB=D3ZHH8	Protein Srf	ISS	15326221	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P02736	Coenzyme A biosynthesis	P02885	Pantothenate kinase	MOUSE|MGI=MGI=2387464|UniProtKB=Q8R2W9	Pantothenate kinase 3	ISS			PTHR12280:SF21	PANTOTHENATE KINASE 3
P00057	Wnt signaling pathway	P01468	APC	DROME|FlyBase=FBgn0015589|UniProtKB=Q9VAS9	APC-like, isoform A	IDA	8259518	PubMed	PTHR12607:SF12	APC-LIKE, ISOFORM A-RELATED
P00005	Angiogenesis	P00223	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	HUMAN|HGNC=18638|UniProtKB=Q5T7P8	Synaptotagmin-6	ISS			PTHR10024:SF45	SYNAPTOTAGMIN-6
P00006	Apoptosis signaling pathway	P00257	Bcl-xL	CHICK|Ensembl=ENSGALG00000006211|UniProtKB=Q07816	Bcl-2-like protein 1	ISS			PTHR11256:SF12	BCL-2-LIKE PROTEIN 1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04397	p53 pathway by glucose deprivation	P04641	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05730	Endogenous cannabinoid signaling	P05746	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	XENTR|Xenbase=XB-GENE-956713|UniProtKB=Q5XGD8	Guanine nucleotide binding protein, beta 3	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	ASHGO|EnsemblGenome=AGOS_ABR222W|UniProtKB=Q75D00	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MACMU|Ensembl=ENSMMUG00000016675|UniProtKB=F6VTB5	Uncharacterized protein	ISS	11554554	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00036	Interleukin signaling pathway	P00979	MAPKAPK2	MACMU|Ensembl=ENSMMUG00000023567|UniProtKB=F7HHY8	Uncharacterized protein	ISS	9628873	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00052	TGF-beta signaling pathway	P01279	Smurfs	RAT|RGD=1594738|UniProtKB=A0A0G2K612	Protein Smurf1	ISS	11252892	PubMed	PTHR11254:SF293	E3 UBIQUITIN-PROTEIN LIGASE SMURF1
P00021	FGF signaling pathway	P00645	Rac	MACMU|Ensembl=ENSMMUG00000021075|UniProtKB=F7GY91	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	YEAST|SGD=S000005565|UniProtKB=P38930	Casein kinase II subunit beta'	IDA	10806215	PubMed	PTHR11740:SF13	CASEIN KINASE II SUBUNIT BETA'
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05912	Dopamine receptor mediated signaling pathway	P05953	EPB41L1	PANTR|Ensembl=ENSPTRG00000013455|UniProtKB=H2QKA1	Uncharacterized protein	ISS	12181426	PubMed	PTHR23280:SF24	BAND 4.1-LIKE PROTEIN 1
P00018	EGF receptor signaling pathway	P00542	EGFR	HUMAN|HGNC=3432|UniProtKB=Q15303	Receptor tyrosine-protein kinase erbB-4	IGI	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00018	EGF receptor signaling pathway	P00539	14-3-3	DANRE|ZFIN=ZDB-GENE-061023-2|UniProtKB=E7F354	Uncharacterized protein	ISS	1317796	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00562	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00005	Angiogenesis	P00203	Erk	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00048	PI3 kinase pathway	P01178	Grb2	DANRE|ZFIN=ZDB-GENE-040426-1975|UniProtKB=Q6PC73	Growth factor receptor-bound protein 2	ISS	4504111	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	CHICK|Ensembl=ENSGALG00000000681|UniProtKB=E1C3P6	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00021	FGF signaling pathway	P00644	p38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	IGI	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	CANLF|Gene=SLC1A6|UniProtKB=Q9N1R2	Excitatory amino acid transporter 4	IC	94365697	PubMed	PTHR11958:SF67	EXCITATORY AMINO ACID TRANSPORTER 4
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=12787|UniProtKB=P56706	Protein Wnt-7b	IDA	11266476	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	IC	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	176910	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01454	betaTrCP	DANRE|ZFIN=ZDB-GENE-030131-6305|UniProtKB=Q7ZVZ1	F-box and WD-40 domain protein 11b	ISS	10074433	PubMed	PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	HUMAN|HGNC=17780|UniProtKB=Q562R1	Beta-actin-like protein 2	IDA	11889126	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00023	General transcription regulation	P00666	TFIIE	MOUSE|MGI=MGI=1921447|UniProtKB=Q9D0D5	General transcription factor IIE subunit 1	ISS	189962	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00034	Integrin signalling pathway	P00944	Actin	MONDO|Ensembl=ENSMODG00000024992|UniProtKB=F6TUR3	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	BRAFL|Gene=BRAFLDRAFT_124869|UniProtKB=C3ZEW0	Putative uncharacterized protein	ISS			PTHR23050:SF263	SUBFAMILY NOT NAMED
P00020	FAS signaling pathway	P00614	ASK1	PANTR|Ensembl=ENSPTRG00000024326|UniProtKB=H2R231	Uncharacterized protein	TAS			PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02788	Xanthine and guanine salvage pathway	P03247	Xanthine phosphoribosyl transferase	THEMA|EnsemblGenome=TM_0206|UniProtKB=Q9WY49	Hypoxanthine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05913	Enkephalin release	P05977	G-Protein (s)	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00047	PDGF signaling pathway	P01171	PLCgamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04398	p53 pathway feedback loops 2	P04651	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00018	EGF receptor signaling pathway	P00564	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05913	Enkephalin release	P05972	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00624	14-3-3	ORYSJ|EnsemblGenome=OS08G0480800|UniProtKB=Q84J55	14-3-3-like protein GF14-A	ISS	10407019	PubMed	PTHR18860:SF26	14-3-3 FAMILY PROTEIN-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00047	PDGF signaling pathway	P01154	Ras	MONDO|Ensembl=ENSMODG00000025248|UniProtKB=F7F5X1	Uncharacterized protein	ISS	9869449	PubMed	PTHR24070:SF186	GTPASE KRAS
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00805	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00384	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CHICK|Ensembl=ENSGALG00000015835|UniProtKB=F1NZT2	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	XENTR|Xenbase=XB-GENE-491433|UniProtKB=B1H2U0	Pten protein	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00022	General transcription by RNA polymerase I	P00655	UBF1	MACMU|Ensembl=ENSMMUG00000019924|UniProtKB=F7GNN8	Uncharacterized protein	ISS			PTHR13711:SF216	NUCLEOLAR TRANSCRIPTION FACTOR 1
P02741	Flavin biosynthesis	P02936	FAD synthetase	THEMA|EnsemblGenome=TM_0857|UniProtKB=Q9WZW1	Riboflavin biosynthesis protein	ISS			PTHR22749:SF2	RIBOFLAVIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00048	PI3 kinase pathway	P01177	P110ACT	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00029	Huntington disease	P00810	GAPDH	RAT|RGD=2661|UniProtKB=P04797	Glyceraldehyde-3-phosphate dehydrogenase	IPI	8612237	PubMed	PTHR10836:SF51	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE
P00034	Integrin signalling pathway	P00916	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00012	Cadherin signaling pathway	P00470	F-actin	PHYPA|Gene=PHYPADRAFT_172686|UniProtKB=A9TYG6	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00054	Toll receptor signaling pathway	P01354	NFkappaB	HUMAN|HGNC=7795|UniProtKB=Q00653	Nuclear factor NF-kappa-B p100 subunit	ISS	9133421	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00060	Ubiquitin proteasome pathway	P01492	E1	ARATH|TAIR=AT5G19180|UniProtKB=O65041	NEDD8-activating enzyme E1 catalytic subunit	ISS			PTHR10953:SF6	NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT
P04398	p53 pathway feedback loops 2	P04658	PTEN	CANLF|Gene=PTEN|UniProtKB=P60483	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P06664	Gonadotropin-releasing hormone receptor pathway	P06845	Alk4	MOUSE|MGI=MGI=1338944|UniProtKB=Q61271	Activin receptor type-1B	RCA	9395284	PubMed	PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	HUMAN|HGNC=10934|UniProtKB=P54219	Chromaffin granule amine transporter	ISS	92370677	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00029	Huntington disease	P00797	p53	TAKRU|Ensembl=ENSTRUG00000009773|UniProtKB=H2TIQ4	Uncharacterized protein	ISS			PTHR12195:SF2	CYTOPLASMIC FMR1-INTERACTING PROTEIN 1
P00029	Huntington disease	P00790	beta-Tubulin	SCHPO|PomBase=SPBC26H8.07c|UniProtKB=P05219	Tubulin beta chain	TAS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P06959	CCKR signaling map	P07189	CETP	HUMAN|HGNC=1869|UniProtKB=P11597	Cholesteryl ester transfer protein	RCA	19502590	PubMed	PTHR10504:SF12	CHOLESTERYL ESTER TRANSFER PROTEIN
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00046	Oxidative stress response	P01135	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	TAS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00034	Integrin signalling pathway	P00947	Laminin	HUMAN|HGNC=6492|UniProtKB=P11047	Laminin subunit gamma-1	IPI	2538453	PubMed	PTHR10574:SF270	LAMININ SUBUNIT GAMMA-1
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	CANLF|Ensembl=ENSCAFG00000019633|UniProtKB=F1PDC7	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00059	p53 pathway	P01481	ATM/ATR	SCHPO|PomBase=SPBC216.05|UniProtKB=Q02099	Protein kinase rad3	TAS	10196661	PubMed	PTHR11139:SF69	SERINE/THREONINE-PROTEIN KINASE ATR
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	HUMAN|HGNC=7849|UniProtKB=P15531	Nucleoside diphosphate kinase A	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000035697|UniProtKB=Q28024	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IDA	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00048	PI3 kinase pathway	P01196	PDK1	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	RAT|RGD=2558|UniProtKB=P50279	Syntaxin-2	IC			PTHR19957:SF36	SYNTAXIN-2
P02783	Tryptophan biosynthesis	P03206	Anthranilate synthase	DEIRA|EnsemblGenome=DR_1766|UniProtKB=Q9RTJ6	Anthranilate synthase component 2	RCA			PTHR43418:SF4	MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN
P00029	Huntington disease	P00769	N-Wasp	ORNAN|Ensembl=ENSOANG00000004830|UniProtKB=F7E2I0	Uncharacterized protein	ISS	12932731	PubMed	PTHR23202:SF39	NEURAL WISKOTT-ALDRICH SYNDROME PROTEIN
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000007882|UniProtKB=G3X7Z2	Uncharacterized protein	ISS	14624853	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	ORYSJ|EnsemblGenome=OS10G0563700|UniProtKB=Q7XC37	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P02721	ATP synthesis	P02794	F1 beta	HUMAN|HGNC=830|UniProtKB=P06576	ATP synthase subunit beta, mitochondrial	ISS	2896550	PubMed	PTHR15184:SF44	ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MACMU|Ensembl=ENSMMUG00000019342|UniProtKB=F6PVY4	Uncharacterized protein	ISS	12473693	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	MOUSE|MGI=MGI=109482|UniProtKB=P97445	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	8386525	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00025	Hedgehog signaling pathway	P00682	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	IDA	176910	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000002125|UniProtKB=F1N461	Uncharacterized protein	ISS	6309844	PubMed	PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	XENTR|Xenbase=XB-GENE-490534|UniProtKB=F7CQJ3	Uncharacterized protein (Fragment)	ISS	5031595	gi	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P02738	De novo purine biosynthesis	P02892	5-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase	HALSA|EnsemblGenome=VNG_0415G|UniProtKB=Q9HS42	Adenylosuccinate lyase	ISS			PTHR43411:SF1	ADENYLOSUCCINATE LYASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IDA	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05940	GRK5	BOVIN|Ensembl=ENSBTAG00000007981|UniProtKB=P43249	G protein-coupled receptor kinase 5	RCA	8288567	PubMed	PTHR24355:SF27	G PROTEIN-COUPLED RECEPTOR KINASE 5
P00053	T cell activation	P01311	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IDA	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01185	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	MOUSE|MGI=MGI=108059|UniProtKB=Q00262	Syntaxin-2	ISS	12737809	PubMed	PTHR19957:SF36	SYNTAXIN-2
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00005	Angiogenesis	P00203	Erk	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	20384797	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00036	Interleukin signaling pathway	P00967	c-fos	MONDO|Ensembl=ENSMODG00000005927|UniProtKB=F6WX28	Uncharacterized protein	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02734	Chorismate biosynthesis	P02874	Shikimate kinase	ARATH|TAIR=AT2G21940|UniProtKB=Q9SJ05	Shikimate kinase 1, chloroplastic	ISS			PTHR21087:SF16	SHIKIMATE KINASE 1, CHLOROPLASTIC-RELATED
P00012	Cadherin signaling pathway	P00471	Cadherin	CANLF|Ensembl=ENSCAFG00000004935|UniProtKB=F1P802	Uncharacterized protein	ISS	8120095	PubMed	PTHR43912:SF7	PROTOCADHERIN-20
P00011	Blood coagulation	P00405	FVIII	PANTR|Ensembl=ENSPTRG00000022455|UniProtKB=H2R1R6	Uncharacterized protein	ISS	4503647	gi	PTHR45309:SF1	COAGULATION FACTOR VIII
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MACMU|Ensembl=ENSMMUG00000009763|UniProtKB=F6ZIC3	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF368	MYOSIN-8
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	TAS	10395542	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00054	Toll receptor signaling pathway	P01369	MKK1	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04440	Beta2	MACMU|Ensembl=ENSMMUG00000002214|UniProtKB=Q28509	Beta-2 adrenergic receptor	ISS	7669252	PubMed	PTHR24248:SF21	BETA-2 ADRENERGIC RECEPTOR
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00020	FAS signaling pathway	P00616	Nuclear Lamin	MACMU|Ensembl=ENSMMUG00000016096|UniProtKB=F7GLE9	Prelamin-A/C isoform 1	ISS	11165516	PubMed	PTHR23239:SF158	PRELAMIN-A/C
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00907	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01446	Calcineurin	RAT|RGD=3382|UniProtKB=P63329	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	IDA	7532676	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DANRE|ZFIN=ZDB-GENE-040625-35|UniProtKB=Q6IQL9	Novel actin protein	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04393	Ras Pathway	P04569	Cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00005	Angiogenesis	P00203	Erk	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02775	Salvage pyrimidine ribonucleotides	P03156	CDP kinase	DROME|FlyBase=FBgn0263398|UniProtKB=Q9VC99	Probable uridine-cytidine kinase	ISS			PTHR10285:SF70	URIDINE-CYTIDINE KINASE 2
P00034	Integrin signalling pathway	P00912	Arp2/3	HUMAN|HGNC=708|UniProtKB=O15511	Actin-related protein 2/3 complex subunit 5	IPI	12932731	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	DROME|FlyBase=FBgn0002842|UniProtKB=Q9VP40	Spermatocyte arrest	ISS	604904	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00056	VEGF signaling pathway	P01425	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	21157398	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	CHICK|Ensembl=ENSGALG00000002932|UniProtKB=O57535	Nucleoside diphosphate kinase	ISS			PTHR11349:SF57	NUCLEOSIDE DIPHOSPHATE KINASE B
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00058	mRNA splicing	P01473	U6	RAT|RGD=1310555|UniProtKB=A0A0G2JTI7	Protein Prpf3	ISS	12875835	PubMed	PTHR14212:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3
P00059	p53 pathway	G04702	p53	CANLF|Ensembl=ENSCAFG00000013961|UniProtKB=F1PL57	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00018	EGF receptor signaling pathway	P00545	JNK1-3	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05913	Enkephalin release	P05972	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	PANTR|Ensembl=ENSPTRG00000008601|UniProtKB=H2QBY1	Arrestin, beta 2	ISS	9388255	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	TAS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00049	Parkinson disease	P01217	beta-Synuclein	CANLF|Ensembl=ENSCAFG00000016646|UniProtKB=E2R6G0	Beta-synuclein	ISS	11683992	PubMed	PTHR13820:SF4	BETA-SYNUCLEIN
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00019	Endothelin signaling pathway	P00582	COX-2	MACMU|Ensembl=ENSMMUG00000016857|UniProtKB=F7BWZ9	Uncharacterized protein	ISS	11861541	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CAEEL|WormBase=WBGene00000064|UniProtKB=P10984	Actin-2	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00047	PDGF signaling pathway	P01160	IP3 receptor	PANTR|Ensembl=ENSPTRG00000004781|UniProtKB=H2QLZ4	Uncharacterized protein	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	TAS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00005	Angiogenesis	P00222	VEGFR-2	HUMAN|HGNC=6307|UniProtKB=P35968	Vascular endothelial growth factor receptor 2	IDA	11221852	PubMed	PTHR24416:SF45	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2
P00030	Hypoxia response via HIF activation	P00819	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00373	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00539	14-3-3	RAT|RGD=3980|UniProtKB=P63102	14-3-3 protein zeta/delta	ISS	1499718	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CANLF|Ensembl=ENSCAFG00000019823|UniProtKB=E2R4I7	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	IGI	97320448	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00051	TCA cycle	P01271	Fumarase	MOUSE|MGI=MGI=95530|UniProtKB=P97807	Fumarate hydratase, mitochondrial	ISS	227665	gi	PTHR11444:SF1	FUMARATE HYDRATASE, MITOCHONDRIAL
P00006	Apoptosis signaling pathway	P00274	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00036	Interleukin signaling pathway	P00974	Receptor subunit beta	MACMU|Ensembl=ENSMMUG00000000651|UniProtKB=F6X0C8	Uncharacterized protein	ISS	8943050	PubMed	PTHR23036:SF79	INTERLEUKIN-12 RECEPTOR SUBUNIT BETA-2
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00006	Apoptosis signaling pathway	P00310	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00796	Kainate receptor	PANTR|Gene=GRIK4|UniProtKB=Q5IS46	Glutamate receptor ionotropic, kainate 4	ISS	11319238	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00049	Parkinson disease	P01208	Hsp70	HALSA|EnsemblGenome=VNG_0491G|UniProtKB=Q9HRY2	Chaperone protein DnaK	IDA	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P00010	B cell activation	P00371	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00034	Integrin signalling pathway	P00951	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00016	Cytoskeletal regulation by Rho GTPase	P00521	Profilin	RAT|RGD=621825|UniProtKB=P62963	Profilin-1	ISS			PTHR13936:SF14	PROFILIN-1
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	15737619	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00543	ERK1-2	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	IGI	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00046	Oxidative stress response	P01129	JNK1/2	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00772	FIP-2	ORNAN|Ensembl=ENSOANG00000006164|UniProtKB=F7BRR0	Uncharacterized protein	ISS			PTHR12757:SF3	TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 8
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	DANRE|ZFIN=ZDB-GENE-991119-4|UniProtKB=Q9W6T7	Presenilin-1	IDA	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	BOVIN|Ensembl=ENSBTAG00000046248|UniProtKB=Q58CQ2	Actin-related protein 2/3 complex subunit 1B	ISS	12932731	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	CHICK|Ensembl=ENSGALG00000003270|UniProtKB=F1NR31	Uncharacterized protein	ISS	11861492	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	91056091	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	TAS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02729	Ascorbate degradation	P02852	L-xylulose-5-phosphate-3-epimerase	GLOVI|Gene=BAC91489|UniProtKB=Q7NFH7	Ribulose-phosphate 3-epimerase	ISS			PTHR11749:SF3	RIBULOSE-PHOSPHATE 3-EPIMERASE
P00056	VEGF signaling pathway	P01423	p38MAPK	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02758	Ornithine degradation	P03055	Aminobutyraldehyde dehydrogenase	RHOBA|EnsemblGenome=RB10062|UniProtKB=Q7UKM2	Uncharacterized protein	ISS			PTHR43104:SF2	L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CHICK|Ensembl=ENSGALG00000012894|UniProtKB=P30372	Muscarinic acetylcholine receptor M2	IDA	11166329	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00021	FGF signaling pathway	P00627	ERK1-2	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IGI	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	ARATH|TAIR=AT5G08080|UniProtKB=Q8VZU2	Syntaxin-132	IC			PTHR19957:SF144	SYNTAXIN-132-RELATED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04393	Ras Pathway	P04553	PAK	MOUSE|MGI=MGI=1339975|UniProtKB=O88643	Serine/threonine-protein kinase PAK 1	IDA	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00060	Ubiquitin proteasome pathway	P01492	E1	PANTR|Ensembl=ENSPTRG00000016099|UniProtKB=H2QPJ4	Ubiquitin-like modifier activating enzyme 6	ISS			PTHR10953:SF186	UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 6
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	TAS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	G04709	MDM-2	BOVIN|Gene=MDM4|UniProtKB=Q2HJ21	Protein Mdm4	ISS			PTHR13844:SF20	PROTEIN MDM4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	TAS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4388|UniProtKB=P38405	Guanine nucleotide-binding protein G(olf) subunit alpha	IC	2106672	PubMed	PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	HUMAN|HGNC=4579|UniProtKB=P39086	Glutamate receptor ionotropic, kainate 1	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00030	Hypoxia response via HIF activation	P00819	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00318	PKCs	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00037	Ionotropic glutamate receptor pathway	P01015	Glu4	MOUSE|MGI=MGI=95811|UniProtKB=Q9Z2W8	Glutamate receptor 4	ISS	12497607	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	BOVIN|Ensembl=ENSBTAG00000015670|UniProtKB=E1B7J7	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00034	Integrin signalling pathway	P00940	Src	XENTR|Xenbase=XB-GENE-489820|UniProtKB=F7DXH6	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00053	T cell activation	P01331	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IDA	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04552	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00034	Integrin signalling pathway	P00922	Collagen	MOUSE|MGI=MGI=88454|UniProtKB=P02463	Collagen alpha-1(IV) chain	IDA	10778855	PubMed	PTHR24023:SF854	COLLAGEN ALPHA-1 IV  CHAIN
P05731	GABA-B receptor II signaling	P05760	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000000985|UniProtKB=F6VRS9	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00053	T cell activation	P01314	nck	HUMAN|HGNC=7665|UniProtKB=O43639	Cytoplasmic protein NCK2	IPI	12874226	PubMed	PTHR44108:SF1	CYTOPLASMIC PROTEIN NCK2
P00034	Integrin signalling pathway	P00907	ERK	MACMU|Ensembl=ENSMMUG00000008503|UniProtKB=F6TGJ6	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	12707323	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02787	Vitamin B6 metabolism	P03244	Pyridoxal kinase	DEIRA|EnsemblGenome=DR_A0184|UniProtKB=Q9RYX0	Pyridoxal kinase PdxY	ISS	10567266	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	IC	2303451	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00864	MEK	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS			PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00047	PDGF signaling pathway	P01161	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00366	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000023202|UniProtKB=F7EU36	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04398	p53 pathway feedback loops 2	P04651	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P05918	p38 MAPK pathway	P06034	MKK4	PANTR|Ensembl=ENSPTRG00000008783|UniProtKB=H2QCA7	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00005	Angiogenesis	P00221	JNK1	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	ISS	7600581	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	PANTR|Ensembl=ENSPTRG00000005528|UniProtKB=H2Q705	Nucleoside diphosphate kinase	ISS			PTHR11349:SF68	NUCLEOSIDE DIPHOSPHATE KINASE-RELATED
P00019	Endothelin signaling pathway	P00566	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01192	p110	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01199	Galpha	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	THEKO|EnsemblGenome=TK0528|UniProtKB=Q5JF06	Serine hydroxymethyltransferase	ISS			PTHR11680:SF21	SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC
P00054	Toll receptor signaling pathway	P01375	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00021	FGF signaling pathway	P00633	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00020	FAS signaling pathway	P00601	c-Jun	XENTR|Xenbase=XB-GENE-482228|UniProtKB=F6RYL1	Uncharacterized protein	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P02781	Threonine biosynthesis	P03189	Aspartate kinase	DEIRA|EnsemblGenome=DR_1365|UniProtKB=Q9RUL9	Aspartokinase	ISS			PTHR21499:SF3	ASPARTOKINASE
P00010	B cell activation	P00384	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00231	HSP27	ANOGA|EnsemblGenome=AGAP007158|UniProtKB=Q7PCM8	AGAP007158-PA	ISS			PTHR11527:SF252	HEAT SHOCK PROTEIN BETA-11
P00048	PI3 kinase pathway	P01192	p110	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04547	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000009900|UniProtKB=F1NHL1	Serine/threonine-protein kinase	ISS	12393506	PubMed	PTHR22968:SF9	SERINE/THREONINE-PROTEIN KINASE D1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04393	Ras Pathway	P04570	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	ANOGA|Gene=AgaP_AGAP011360|UniProtKB=Q7Q2V9	AGAP011360-PA (Fragment)	ISS	9388255	PubMed	PTHR11792:SF17	KURTZ ARRESTIN
P04393	Ras Pathway	P04558	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00029	Huntington disease	P00787	MAPKK4	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00047	PDGF signaling pathway	P01153	GSK3	ORYSJ|EnsemblGenome=OS01G0252100|UniProtKB=Q9LIS6	Os01g0252100 protein	ISS	12615961	PubMed	PTHR24057:SF13	SHAGGY-RELATED PROTEIN KINASE ALPHA-RELATED
P00009	Axon guidance mediated by netrin	P00364	cdc42	TAKRU|Ensembl=ENSTRUG00000013411|UniProtKB=H2UB84	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00045	Notch signaling pathway	P01112	CoR	HUMAN|HGNC=7673|UniProtKB=Q9Y618	Nuclear receptor corepressor 2	TAS	11112321	PubMed	PTHR13992:SF21	NUCLEAR RECEPTOR COREPRESSOR 2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	MACMU|Ensembl=ENSMMUG00000013100|UniProtKB=F6ZUP6	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF4	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00238	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00035	Interferon-gamma signaling pathway	P00956	SOCS	PANTR|Ensembl=ENSPTRG00000006368|UniProtKB=H2Q8C3	Uncharacterized protein	ISS	15032587	PubMed	PTHR44282:SF2	SUPPRESSOR OF CYTOKINE SIGNALING 4
P00004	Alzheimer disease-presenilin pathway	P00126	Fe65	CANLF|Ensembl=ENSCAFG00000006420|UniProtKB=E2QWV4	Uncharacterized protein	ISS	11441186	PubMed	PTHR14058:SF5	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05938	RhoA	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	ISS	10556059	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00049	Parkinson disease	P01230	Src kinase	MOUSE|MGI=MGI=103265|UniProtKB=Q922K9	Tyrosine-protein kinase FRK	IDA	8054685	PubMed	PTHR24418:SF296	TYROSINE-PROTEIN KINASE FRK
P00034	Integrin signalling pathway	P00907	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04668	p53	HUMAN|HGNC=12003|UniProtKB=O15350	Tumor protein p73	TAS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IPI	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00004	Alzheimer disease-presenilin pathway	P00117	E-cadherin C-terminal fragment	MACMU|Ensembl=ENSMMUG00000010393|UniProtKB=F7D992	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P02738	De novo purine biosynthesis	P02891	GDP kinase	RAT|RGD=70497|UniProtKB=Q05982	Nucleoside diphosphate kinase A	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P00005	Angiogenesis	P00211	GSK3beta	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	BOVIN|Ensembl=ENSBTAG00000037726|UniProtKB=P10895	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	10934033	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00004	Alzheimer disease-presenilin pathway	P00131	HAC1	HUMAN|HGNC=15974|UniProtKB=Q9C040	Tripartite motif-containing protein 2	IDA			PTHR44028:SF2	TRIPARTITE MOTIF-CONTAINING PROTEIN 2
P00020	FAS signaling pathway	P00610	MKK4	BOVIN|Ensembl=ENSBTAG00000012103|UniProtKB=A5PJP8	MAP2K4 protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P01486	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	BOVIN|Ensembl=ENSBTAG00000020756|UniProtKB=A6QLB8	GSK3A protein	ISS	21361340	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00057	Wnt signaling pathway	P01438	PP2A	MACMU|Ensembl=ENSMMUG00000020819|UniProtKB=F7HSM1	Serine/threonine-protein phosphatase	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	10799299	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	PANTR|Ensembl=ENSPTRG00000018890|UniProtKB=Q5R1X3	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	HUMAN|HGNC=6181|UniProtKB=Q14571	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	DROME|FlyBase=FBgn0004087|UniProtKB=P17719	Dihydrofolate reductase	ISS			PTHR22778:SF16	DIHYDROFOLATE REDUCTASE
P00047	PDGF signaling pathway	P01153	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00034	Integrin signalling pathway	P00924	Raf	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	MOUSE|MGI=MGI=3039562|UniProtKB=Q6NZA9	Transcription initiation factor TFIID subunit 9B	ISS			PTHR12595:SF3	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 9B
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00006	Apoptosis signaling pathway	P00269	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	20331588	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	CHICK|Ensembl=ENSGALG00000002859|UniProtKB=F6UBD2	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00029	Huntington disease	P00780	Microtubule	MONDO|Ensembl=ENSMODG00000017213|UniProtKB=F6WYK8	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=2136018|UniProtKB=Q9QYS1	Protein Wnt-16	IDA	8717036	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P04398	p53 pathway feedback loops 2	P04661	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	ISS	7937853	PubMed	PTHR10048:SF14	PI-3 KINASE
P04393	Ras Pathway	P04547	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00054	Toll receptor signaling pathway	P01346	TLR	ANOGA|EnsemblGenome=AGAP001004|UniProtKB=Q8WRE5	AGAP001004-PA	ISS			PTHR45263:SF1	PROTEIN TOLL
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00005	Angiogenesis	P00187	beta catenin	ORNAN|Ensembl=ENSOANG00000006811|UniProtKB=F6WBD5	Uncharacterized protein	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P02787	Vitamin B6 metabolism	P03236	Pyridoxamine phosphate oxidase	SYNY3|EnsemblGenome=BAA18303|UniProtKB=P74211	Pyridoxine/pyridoxamine 5'-phosphate oxidase	ISS	8590279	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00048	PI3 kinase pathway	P01199	Galpha	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	FUSNN|EnsemblGenome=FN1298|UniProtKB=Q8RE31	Adenylate kinase	ISS			PTHR23359:SF22	GTP:AMP PHOSPHOTRANSFERASE, MITOCHONDRIAL
P04398	p53 pathway feedback loops 2	P04661	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P02736	Coenzyme A biosynthesis	P02885	Pantothenate kinase	HUMAN|HGNC=19366|UniProtKB=Q9NVE7	Pantothenate kinase 4	ISS			PTHR12280:SF20	PANTOTHENATE KINASE 4
P05731	GABA-B receptor II signaling	P05753	Ca channel	MACMU|Ensembl=ENSMMUG00000017256|UniProtKB=F7GWW5	Uncharacterized protein	ISS	14526084	PubMed	PTHR10037:SF137	VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1G
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	PANTR|Ensembl=ENSPTRG00000011042|UniProtKB=H2QGF5	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	PANTR|Ensembl=ENSPTRG00000008411|UniProtKB=H2QBM1	Uncharacterized protein	ISS	604905	OMIM	PTHR15319:SF1	TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT C
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000025240|UniProtKB=F7A7I3	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00005	Angiogenesis	P00200	Dsh	CANLF|Ensembl=ENSCAFG00000016066|UniProtKB=E2R7K2	Uncharacterized protein	ISS	10409711	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P00018	EGF receptor signaling pathway	P00541	Spry	HUMAN|HGNC=15533|UniProtKB=Q9C004	Protein sprouty homolog 4	ISS	22024232	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00907	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04572	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IDA	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PHYPA|Gene=PHYPADRAFT_107830|UniProtKB=A9TBG2	Actin 7	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00223	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00877	MLCK	MACMU|Ensembl=ENSMMUG00000019786|UniProtKB=F7G5G3	Uncharacterized protein	ISS	11157482	PubMed	PTHR45411:SF1	MYOSIN LIGHT CHAIN KINASE 3
P00053	T cell activation	P01332	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	IDA	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00547	PP2A	MOUSE|MGI=MGI=2388479|UniProtKB=Q6PD03	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform	ISS	10092233	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00634	MEKK1-5	BOVIN|Ensembl=ENSBTAG00000008151|UniProtKB=F1MH06	Uncharacterized protein	ISS	9006902	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P04392	P53 pathway feedback loops 1	G04685	p73DeltaN	CANLF|Ensembl=ENSCAFG00000013961|UniProtKB=F1PL57	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00054	Toll receptor signaling pathway	P01352	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00048	PI3 kinase pathway	P01192	p110	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00052	TGF-beta signaling pathway	P01292	RSmads	MOUSE|MGI=MGI=109452|UniProtKB=P70340	Mothers against decapentaplegic homolog 1	TAS	12736218	PubMed	PTHR13703:SF23	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00049	Parkinson disease	P01219	SAPK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MACMU|Ensembl=ENSMMUG00000009763|UniProtKB=F6ZIC3	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF368	MYOSIN-8
P04393	Ras Pathway	P04569	Cdc42	YEAST|SGD=S000004219|UniProtKB=P19073	Cell division control protein 42	IDA	12932731	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	BRAFL|Gene=BRAFLDRAFT_220697|UniProtKB=C3ZSF0	Putative uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	TAS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00741	GPRK	PANTR|Ensembl=ENSPTRG00000014187|UniProtKB=H2R714	Protein-serine/threonine kinase	RCA			PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P00048	PI3 kinase pathway	P01192	p110	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	TAKRU|Ensembl=ENSTRUG00000014690|UniProtKB=H2UKR9	Uncharacterized protein	ISS	2137198	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00057	Wnt signaling pathway	P01435	SWI/SNF	BOVIN|Gene=SMARCA4|UniProtKB=A7Z019	Transcription activator BRG1	ISS	11532957	PubMed	PTHR10799:SF76	TRANSCRIPTION ACTIVATOR BRG1
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	MONDO|Ensembl=ENSMODG00000003244|UniProtKB=F6THF0	Uncharacterized protein	ISS	9254684	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00021	FGF signaling pathway	P00623	FGF	CHICK|Ensembl=ENSGALG00000026853|UniProtKB=P48801	Fibroblast growth factor 3	IGI	95309122	PubMed	PTHR11486:SF26	FIBROBLAST GROWTH FACTOR 3
P00009	Axon guidance mediated by netrin	P00363	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	RCA	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	STRPU|EnsemblGenome=SPU_018419|UniProtKB=W4YRI6	Uncharacterized protein	ISS	97210759	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00048	PI3 kinase pathway	P01190	PDK1 ACT	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	IGI	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00060	Ubiquitin proteasome pathway	P01490	E3	BOVIN|Ensembl=ENSBTAG00000002698|UniProtKB=E1BCU1	Uncharacterized protein	ISS			PTHR11254:SF352	UBIQUITIN-PROTEIN LIGASE E3B
P00029	Huntington disease	P00801	Fos protein	PANTR|Ensembl=ENSPTRG00000006553|UniProtKB=A5A6H0	C-fos	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01407	Erk	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00037	Ionotropic glutamate receptor pathway	P01026	KA	HUMAN|HGNC=4579|UniProtKB=P39086	Glutamate receptor ionotropic, kainate 1	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04397	p53 pathway by glucose deprivation	P04641	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00030	Hypoxia response via HIF activation	P00816	VHL	HUMAN|HGNC=12687|UniProtKB=P40337	Von Hippel-Lindau disease tumor suppressor	TAS	14526383	PubMed	PTHR15160:SF1	VON HIPPEL-LINDAU DISEASE TUMOR SUPPRESSOR-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00760	Gtalpha	CANLF|Ensembl=ENSCAFG00000010764|UniProtKB=Q28300	Guanine nucleotide-binding protein G(t) subunit alpha-1	IDA	6264430	PubMed	PTHR10218:SF67	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-1
P05913	Enkephalin release	P05974	G-Protein (i)	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00572	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	TAS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	ARATH|TAIR=AT5G35630|UniProtKB=Q43127	Glutamine synthetase, chloroplastic/mitochondrial	ISS			PTHR20852:SF53	GLUTAMINE SYNTHETASE, CHLOROPLASTIC/MITOCHONDRIAL
P00057	Wnt signaling pathway	P01432	Beta-Catenin	MOUSE|MGI=MGI=88276|UniProtKB=Q02248	Catenin beta-1	IDA	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P06959	CCKR signaling map	P07145	Paxillin	HUMAN|HGNC=9718|UniProtKB=P49023	Paxillin	RCA	11181948	PubMed	PTHR24216:SF11	PAXILLIN
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01428	Frizzled	MOUSE|MGI=MGI=108476|UniProtKB=Q61086	Frizzled-3	IDA	12549854	PubMed	PTHR11309:SF22	FRIZZLED-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00045	Notch signaling pathway	P01101	Su(H)	HUMAN|HGNC=5724|UniProtKB=Q06330	Recombining binding protein suppressor of hairless	ISS	15187023	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00047	PDGF signaling pathway	P01161	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00629	PP2A	STRPU|EnsemblGenome=SPU_025182|UniProtKB=W4ZAK5	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=99403|UniProtKB=Q60614	Adenosine receptor A2b	IDA			PTHR24246:SF18	ADENOSINE RECEPTOR A2B
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	RAT|RGD=1359133|UniProtKB=Q6AY07	Fructose-bisphosphate aldolase	ISS	6086339	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00021	FGF signaling pathway	P00623	FGF	MACMU|Ensembl=ENSMMUG00000023509|UniProtKB=F7E243	Fibroblast growth factor	ISS	12057924	PubMed	PTHR11486:SF86	FIBROBLAST GROWTH FACTOR 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9066|UniProtKB=P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	TAS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00048	PI3 kinase pathway	P01199	Galpha	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	IC	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00047	PDGF signaling pathway	P01174	Rho	RAT|RGD=1310923|UniProtKB=D3ZMS4	Protein Arhgap26	ISS	8649427	PubMed	PTHR12552:SF4	RHO GTPASE-ACTIVATING PROTEIN 26
P00029	Huntington disease	G01533	Bax	BOVIN|Ensembl=ENSBTAG00000013340|UniProtKB=O02703	Apoptosis regulator BAX	ISS	14963330	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00748	Gbeta5L	BOVIN|Ensembl=ENSBTAG00000003762|UniProtKB=A5PJS1	GNB5 protein	ISS	1499560	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MOUSE|MGI=MGI=105932|UniProtKB=P55104	Inhibin beta C chain	TAS	9759503	PubMed	PTHR11848:SF130	INHIBIN BETA C CHAIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	ANOGA|EnsemblGenome=AGAP002972|UniProtKB=Q7QD60	AGAP002972-PA	IC	85270494	PubMed	PTHR18945:SF430	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-LIKE 2
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=109356|UniProtKB=O09044	Synaptosomal-associated protein 23	IC	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00540	MKK3,6	MACMU|Ensembl=ENSMMUG00000001051|UniProtKB=F6QNB5	Dual specificity mitogen-activated protein kinase kinase 6	ISS	8622669	PubMed	PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P00034	Integrin signalling pathway	P00926	GRAF	MOUSE|MGI=MGI=1918552|UniProtKB=Q6ZQ82	Rho GTPase-activating protein 26	ISS	8649427	PubMed	PTHR12552:SF4	RHO GTPASE-ACTIVATING PROTEIN 26
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	RAT|RGD=708567|UniProtKB=O88828	DNA-directed RNA polymerases I, II, and III subunit RPABC2	ISS	12841771	gi	PTHR10773:SF12	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2
P00015	Circadian clock system	G01504	bmal1	DROME|FlyBase=FBgn0023094|UniProtKB=O61734	Protein cycle	IDA	9630224	PubMed	PTHR23042:SF99	PROTEIN CYCLE
P00006	Apoptosis signaling pathway	P00273	p53	MOUSE|MGI=MGI=98834|UniProtKB=P02340	Cellular tumor antigen p53	ISS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00025	Hedgehog signaling pathway	P00682	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00010	B cell activation	P00390	Blk	MOUSE|MGI=MGI=88169|UniProtKB=P16277	Tyrosine-protein kinase Blk	IDA	11078745	PubMed	PTHR24418:SF181	TYROSINE-PROTEIN KINASE BLK
P00019	Endothelin signaling pathway	P00587	Raf-1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00559	MEK1-2	NEUCR|EnsemblGenome=EFNCRG00000005922|UniProtKB=V5ILY0	Mitogen activated protein kinase kinase 2	ISS			PTHR24361:SF395	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00034	Integrin signalling pathway	P00907	ERK	BOVIN|Ensembl=ENSBTAG00000005865|UniProtKB=G5E577	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00048	PI3 kinase pathway	P01179	PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00925	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00059	p53 pathway	P04633	P110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	TAS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01167	Ets	MACMU|Ensembl=ENSMMUG00000007880|UniProtKB=F7B6D9	E74-like factor 1	ISS	15298723	PubMed	PTHR11849:SF156	ETS-RELATED TRANSCRIPTION FACTOR ELF-1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00983	Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	IC	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00059	p53 pathway	P04634	Cdc2	HUMAN|HGNC=1771|UniProtKB=P24941	Cyclin-dependent kinase 2	ISS	1846803	PubMed	PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P00053	T cell activation	P01330	IKK	PANTR|Ensembl=ENSPTRG00000033948|UniProtKB=H2RBD4	Conserved helix-loop-helix ubiquitous kinase	ISS	12813046	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	BOVIN|Ensembl=ENSBTAG00000033153|UniProtKB=F1MG21	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00004	Alzheimer disease-presenilin pathway	P00112	LRP C-terminal fragment	MACMU|Ensembl=ENSMMUG00000023317|UniProtKB=F6Y514	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00023	General transcription regulation	P00670	TBP	BOVIN|Ensembl=ENSBTAG00000035370|UniProtKB=Q32LB1	TATA box-binding protein-like protein 1	ISS	600075	OMIM	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	PANTR|Ensembl=ENSPTRG00000006175|UniProtKB=H2R2N7	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF721	MYOSIN-6
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000008429|UniProtKB=F1ML31	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF4	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00057	Wnt signaling pathway	P01455	Smad4	MOUSE|MGI=MGI=1328787|UniProtKB=P97454	Mothers against decapentaplegic homolog 5	IDA	9395284	PubMed	PTHR13703:SF36	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00053	T cell activation	P01294	NFAT	MACMU|Ensembl=ENSMMUG00000012657|UniProtKB=F7E7J1	Uncharacterized protein	ISS	12787506	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00034	Integrin signalling pathway	P00924	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	DROME|FlyBase=FBgn0015278|UniProtKB=Q7K3H0	LD28067p	ISS	96278830	PubMed	PTHR10048:SF64	LD28067P
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	IGI	11665607	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014262|UniProtKB=F7BYS8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00023	General transcription regulation	P00668	TFIIB	PANTR|Ensembl=ENSPTRG00000006786|UniProtKB=H2Q908	Uncharacterized protein	ISS	180660	OMIM	PTHR11618:SF4	TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT
P00029	Huntington disease	P00807	Actin	SCHMA|EnsemblGenome=Smp_183710|UniProtKB=G4VLW1	Putative actin	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00025	Hedgehog signaling pathway	P00682	PKA	NEUCR|EnsemblGenome=EFNCRG00000004240|UniProtKB=Q01386	cAMP-dependent protein kinase regulatory subunit	ISS	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=97614|UniProtKB=Q8R3B1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	10934033	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00004	Alzheimer disease-presenilin pathway	P00114	actin	TRIAD|EnsemblGenome=TriadG63375|UniProtKB=B3S5E4	Non-muscle actin 6.2	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	DROME|FlyBase=FBgn0015278|UniProtKB=Q7K3H0	LD28067p	ISS	7937853	PubMed	PTHR10048:SF64	LD28067P
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IC	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	HUMAN|HGNC=4582|UniProtKB=Q16099	Glutamate receptor ionotropic, kainate 4	ISS	12778120	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	RAT|RGD=61916|UniProtKB=Q08463	Frizzled-1	TAS	11212302	PubMed	PTHR11309:SF81	FRIZZLED-1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	TAS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DROME|FlyBase=FBgn0000047|UniProtKB=P83967	Actin, indirect flight muscle	ISS	10974003	PubMed	PTHR11937:SF368	ACTIN, INDIRECT FLIGHT MUSCLE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	MACMU|Ensembl=ENSMMUG00000006253|UniProtKB=F7H582	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00034	Integrin signalling pathway	P00948	Rho	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	IGI	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	DROME|FlyBase=FBgn0264000|UniProtKB=M9PHV5	Glutamate receptor IB, isoform B	IC	10331083	PubMed	PTHR18966:SF270	GLUTAMATE RECEPTOR 1-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_188187|UniProtKB=E9GJ31	Guanine nucleotide binding protein, q polypeptide	ISS	8457205	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	CRYNJ|EnsemblGenome=CND03830|UniProtKB=Q5KI86	Uncharacterized protein	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CAEBR|Gene=CBG21050|UniProtKB=A8XZA9	Protein CBR-LGC-9	ISS			PTHR18945:SF557	LIGAND-GATED ION CHANNEL
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	RAT|RGD=1308423|UniProtKB=D3ZY89	Protein Taf8	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00047	PDGF signaling pathway	P01160	IP3 receptor	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	MOUSE|MGI=MGI=95808|UniProtKB=P23818	Glutamate receptor 1	ISS	10331083	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DANRE|ZFIN=ZDB-GENE-050417-59|UniProtKB=Q15KE4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00628	JNK1-3	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00702	CPB	MONDO|Ensembl=ENSMODG00000006900|UniProtKB=F6PUU3	Uncharacterized protein	ISS			PTHR22952:SF97	CAMP-RESPONSIVE ELEMENT MODULATOR
P00029	Huntington disease	P00778	NMDA receptor	PANTR|Ensembl=ENSPTRG00000004718|UniProtKB=H2Q5I0	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MACMU|Ensembl=ENSMMUG00000001672|UniProtKB=F7G3M7	Uncharacterized protein	ISS	12193720	PubMed	PTHR10845:SF32	REGULATOR OF G-PROTEIN SIGNALING 13
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01161	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01192	p110	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00462	Casein kinase II	DANRE|ZFIN=ZDB-GENE-040625-181|UniProtKB=Q6IQV0	Uncharacterized protein	ISS	10806215	PubMed	PTHR24054:SF28	CASEIN KINASE 2 ALPHA 1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00046	Oxidative stress response	P01138	MKK4	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00010	B cell activation	P00386	Calcineurin	MOUSE|MGI=MGI=107163|UniProtKB=P48453	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	IDA	7532676	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00967	c-fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	HUMAN|HGNC=20289|UniProtKB=Q8N752	Casein kinase I isoform alpha-like	ISS	11437445	PubMed	PTHR11909:SF139	CASEIN KINASE I ISOFORM ALPHA-LIKE
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	MOUSE|MGI=MGI=107191|UniProtKB=P36898	Bone morphogenetic protein receptor type-1B	TAS	10683140	PubMed	PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P00034	Integrin signalling pathway	P00906	Rap1	DANRE|ZFIN=ZDB-GENE-030131-9662|UniProtKB=Q6TEN1	Ras-related protein Rap-1b	ISS	8576107	PubMed	PTHR24070:SF382	RAS-RELATED PROTEIN RAP-1B
P02749	Leucine biosynthesis	P03000	Branched chain amino acid aminotransferase	CANLF|Ensembl=ENSCAFG00000011487|UniProtKB=F1PY28	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF51	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, CYTOSOLIC
P00054	Toll receptor signaling pathway	P01352	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	NAS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IDA	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	TAS	2837282	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MOUSE|MGI=MGI=2448177|UniProtKB=Q71MR7	Formyl peptide receptor-related sequence 7	IC			PTHR24225:SF17	FORMYL PEPTIDE RECEPTOR-RELATED SEQUENCE 6-RELATED
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	MOUSE|MGI=MGI=96828|UniProtKB=Q91ZX7	Prolow-density lipoprotein receptor-related protein 1	IDA	11907044	PubMed	PTHR44025:SF2	PROLOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1
P00045	Notch signaling pathway	P01110	Presenilin	CAEEL|WormBase=WBGene00001985|UniProtKB=O02100	Presenilin hop-1	IGI	98004548	PubMed	PTHR10202:SF14	PRESENILIN HOP-1
P02721	ATP synthesis	P02798	Cyt C	PHANO|EnsemblGenome=SNOG_15669|UniProtKB=Q0TY36	Uncharacterized protein	ISS	1646338	PubMed	PTHR11961:SF12	CYTOCHROME C
P00047	PDGF signaling pathway	P01168	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00470	F-actin	ENTHI|EnsemblGenome=EHI_107290|UniProtKB=B1N2P0	Actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00048	PI3 kinase pathway	G01544	GADD45	HUMAN|HGNC=4095|UniProtKB=P24522	Growth arrest and DNA damage-inducible protein GADD45 alpha	ISS	10097101	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P00030	Hypoxia response via HIF activation	P00817	TOR	MONDO|Ensembl=ENSMODG00000011138|UniProtKB=F7BA89	Uncharacterized protein	ISS	14526383	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00038	JAK/STAT signaling pathway	P01027	STAT	CANLF|Ensembl=ENSCAFG00000015346|UniProtKB=E2RE22	Signal transducer and activator of transcription	ISS	8584036	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	DROME|FlyBase=FBgn0011582|UniProtKB=P41596	Dopamine receptor 1	ISS	11861492	PubMed	PTHR43893:SF6	DOPAMINE RECEPTOR 1
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MONDO|Ensembl=ENSMODG00000020742|UniProtKB=F7A026	Uncharacterized protein	ISS			PTHR24241:SF22	GONADOTROPIN-RELEASING HORMONE RECEPTOR
P00025	Hedgehog signaling pathway	P00692	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P05913	Enkephalin release	P05974	G-Protein (i)	PHYIT|EnsemblGenome=PITG_06376|UniProtKB=D0N4Q3	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta, putative	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00010	B cell activation	P00402	Jnk	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	IC	10074940	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MACMU|Ensembl=ENSMMUG00000019807|UniProtKB=F7G1B1	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF179	REGULATOR OF G-PROTEIN SIGNALING 14
P00029	Huntington disease	P00786	ARF	DANRE|ZFIN=ZDB-GENE-040122-4|UniProtKB=Q6NYD8	ADP-ribosylation factor 2	ISS	11752622	PubMed	PTHR11711:SF299	ADP-RIBOSYLATION FACTOR 2
P00018	EGF receptor signaling pathway	P00547	PP2A	PANTR|Ensembl=ENSPTRG00000006426|UniProtKB=H2Q8F8	Protein phosphatase 2, regulatory subunit B', epsilon isoform	ISS	8703017	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P02762	Pentose phosphate pathway	P03081	Transaldolase	HUMAN|HGNC=11559|UniProtKB=P37837	Transaldolase	ISS	8300619	PubMed	PTHR10683:SF18	TRANSALDOLASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MACMU|Ensembl=ENSMMUG00000016049|UniProtKB=Q95JG1	Gonadotropin-releasing hormone II receptor	IDA	12629106	PubMed	PTHR24241:SF116	GONADOTROPIN-RELEASING HORMONE II RECEPTOR-RELATED
P00006	Apoptosis signaling pathway	P00314	MKK3	ORNAN|Ensembl=ENSOANG00000007732|UniProtKB=F6PXH5	Uncharacterized protein (Fragment)	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00012	Cadherin signaling pathway	P00475	Frizzled	CANLF|Ensembl=ENSCAFG00000013547|UniProtKB=E2QVP7	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF126	FRIZZLED-5
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	RAT|RGD=2735|UniProtKB=Q63273	Glutamate receptor ionotropic, kainate 5	ISS	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00052	TGF-beta signaling pathway	P01286	TGFbeta	DANRE|ZFIN=ZDB-GENE-980526-389|UniProtKB=P35621	Protein DVR-1	TAS	10844590	PubMed	PTHR11848:SF151	EMBRYONIC GROWTH/DIFFERENTIATION FACTOR 1
P00036	Interleukin signaling pathway	P00965	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02772	Pyruvate metabolism	P03140	Pyruvate Carboxylase	CANLF|Ensembl=ENSCAFG00000012081|UniProtKB=F1P6G9	Pyruvate carboxylase	ISS	8048912	PubMed	PTHR43778:SF2	PYRUVATE CARBOXYLASE, MITOCHONDRIAL
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	PANTR|Ensembl=ENSPTRG00000007489|UniProtKB=H2QA49	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	CANLF|Ensembl=ENSCAFG00000011148|UniProtKB=J9P1Y8	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF170	REGULATOR OF G-PROTEIN SIGNALING 9
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	ORYSJ|EnsemblGenome=OS10G0563700|UniProtKB=Q7XC37	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P02783	Tryptophan biosynthesis	P03206	Anthranilate synthase	THEMA|EnsemblGenome=TM_0141|UniProtKB=Q08654	Bifunctional protein TrpGD	RCA			PTHR43418:SF4	MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IC	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00021	FGF signaling pathway	P00633	Ras	CANAL|EnsemblGenome=CaO19.1760|UniProtKB=Q59XU5	Ras-like protein 1	IGI	99445463	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P02750	Lipoate_biosynthesis	P03004	Lipoate synthase	PYRAE|EnsemblGenome=PAE2643|UniProtKB=Q8ZUR9	Probable lipoyl synthase	ISS			PTHR10949:SF0	LIPOYL SYNTHASE, MITOCHONDRIAL
P00005	Angiogenesis	P00212	EphR	MONDO|Ensembl=ENSMODG00000016972|UniProtKB=F6UM70	Uncharacterized protein	ISS			PTHR24416:SF18	EPHRIN TYPE-A RECEPTOR 3
P00018	EGF receptor signaling pathway	P00558	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	BOVIN|Ensembl=ENSBTAG00000045925|UniProtKB=Q9BDI3	Cbp/p300-interacting transactivator 1	TAS	9865691	PubMed	PTHR17045:SF6	CBP/P300-INTERACTING TRANSACTIVATOR 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	ISS	10514528	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00025	Hedgehog signaling pathway	P00682	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	XENTR|Xenbase=XB-GENE-480347|UniProtKB=Q6P640	Actin, alpha cardiac muscle 1	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	YEAST|SGD=S000000438|UniProtKB=P38328	Actin-related protein 2/3 complex subunit 1	ISS	12932731	PubMed	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00059	p53 pathway	P04635	Sumo-1 ligase	DANRE|ZFIN=ZDB-GENE-040801-7|UniProtKB=Q6DHL4	Small ubiquitin-related modifier 2	ISS			PTHR10562:SF11	SMALL UBIQUITIN-RELATED MODIFIER 2-RELATED
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=108061|UniProtKB=P48614	Protein Wnt-10b	IDA	12549854	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MONDO|Ensembl=ENSMODG00000018415|UniProtKB=F6XUZ7	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000002016|UniProtKB=F1P3G1	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	TAS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00922	Collagen	BOVIN|Ensembl=ENSBTAG00000013472|UniProtKB=P02465	Collagen alpha-2(I) chain	IDA	10778855	PubMed	PTHR24023:SF568	COLLAGEN ALPHA-2 I  CHAIN
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	ISS	12488551	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	XENTR|Xenbase=XB-GENE-957124|UniProtKB=F7BDN8	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01159	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00029	Huntington disease	P00795	BDNF	MOUSE|MGI=MGI=88145|UniProtKB=P21237	Brain-derived neurotrophic factor	ISS	11408619	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000023940|UniProtKB=F6RFW8	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00047	PDGF signaling pathway	P01143	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	BOVIN|Ensembl=ENSBTAG00000001575|UniProtKB=F1N6C0	Uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF311	CALMODULIN
P00018	EGF receptor signaling pathway	P00539	14-3-3	DROME|FlyBase=FBgn0020238|UniProtKB=P92177	14-3-3 protein epsilon	IGI	97302963	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00859	NFkappaB	RAT|RGD=70498|UniProtKB=Q63369	Nuclear factor NF-kappa-B p105 subunit (Fragment)	ISS	11739545	PubMed	PTHR24169:SF9	NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT
P05916	Opioid prodynorphin pathway	G06049	preprodynorphin	HUMAN|HGNC=8820|UniProtKB=P01213	Proenkephalin-B	RCA	131330	OMIM	PTHR11438:SF4	PROENKEPHALIN-B
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	NEMVE|Gene=v1g88970|UniProtKB=A7RPN8	Predicted protein (Fragment)	ISS			PTHR23050:SF245	AT16150P-RELATED
P00030	Hypoxia response via HIF activation	P00819	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00021	FGF signaling pathway	P00634	MEKK1-5	MONDO|Ensembl=ENSMODG00000009983|UniProtKB=F6USY2	Uncharacterized protein	ISS	8649450	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00005	Angiogenesis	P00180	Dok-R	MACMU|Ensembl=ENSMMUG00000016914|UniProtKB=F7CPC9	Uncharacterized protein	ISS			PTHR21258:SF42	DOCKING PROTEIN 3
P00034	Integrin signalling pathway	P00920	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	LEIMA|EnsemblGenome=LmjF.35.1730|UniProtKB=E9AEZ4	Putative casein kinase II	ISS	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00052	TGF-beta signaling pathway	P01285	TAK	MACMU|Ensembl=ENSMMUG00000006512|UniProtKB=F7H6S1	Mitogen-activated protein kinase kinase kinase 7 isoform B	RCA			PTHR26392:SF74	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	MOUSE|MGI=MGI=107471|UniProtKB=P31695	Neurogenic locus notch homolog protein 4	IDA	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01089	VAChT	DROME|FlyBase=FBgn0270928|UniProtKB=O17444	Vesicular acetylcholine transporter	IC			PTHR23506:SF13	VESICULAR ACETYLCHOLINE TRANSPORTER
P00021	FGF signaling pathway	P00640	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P05913	Enkephalin release	P05974	G-Protein (i)	EMENI|EnsemblGenome=CADANIAG00002670|UniProtKB=Q5BH99	G-protein beta subunit [Source:UniProtKB/TrEMBLAcc:O74214]	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MACMU|Ensembl=ENSMMUG00000004048|UniProtKB=F6ZR92	Frizzled-4	ISS	8717036	PubMed	PTHR11309:SF23	FRIZZLED-4
P04393	Ras Pathway	P04546	GSK3	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	IDA	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	RCA	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00006	Apoptosis signaling pathway	P00274	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IGI	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00629	PP2A	RAT|RGD=1585097|UniProtKB=A0A0G2JZD1	Protein Ppp2r5c	ISS	8576224	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P00019	Endothelin signaling pathway	P00587	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01188	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	IDA	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00049	Parkinson disease	P01211	ERK	ORYSJ|EnsemblGenome=OS06G0699400|UniProtKB=Q5Z859	Mitogen-activated protein kinase 4	IDA	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00045	Notch signaling pathway	P01104	Serrate	MOUSE|MGI=MGI=1095416|UniProtKB=Q9QXX0	Protein jagged-1	IPI	10551863	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P05731	GABA-B receptor II signaling	P05755	Gbeta	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00004	Alzheimer disease-presenilin pathway	P00172	BACE-1	BOVIN|Ensembl=ENSBTAG00000019365|UniProtKB=Q2HJ40	Beta-secretase 1	ISS	10531052	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00057	Wnt signaling pathway	P01451	Galpha	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	IDA	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MONDO|Ensembl=ENSMODG00000025248|UniProtKB=F7F5X1	Uncharacterized protein	ISS	9869449	PubMed	PTHR24070:SF186	GTPASE KRAS
P04393	Ras Pathway	P04547	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IDA	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8713|UniProtKB=Q9Y5F9	Protocadherin gamma-B6	IDA	8120095	PubMed	PTHR24028:SF66	PROTOCADHERIN GAMMA-B6
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IDA	91072385	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00053	T cell activation	P01311	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MOUSE|MGI=MGI=95823|UniProtKB=Q03391	Glutamate receptor ionotropic, NMDA 2D	ISS	11319238	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	TRYB2|Gene=Tb11.v4.0004|UniProtKB=Q382Q3	Ribonucleoside-diphosphate reductase small chain	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DANRE|ZFIN=ZDB-GENE-050417-267|UniProtKB=F1QUN8	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF263	ACTIN
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00029	Huntington disease	P00775	Rac	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS			PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P05734	Synaptic vesicle trafficking	P05780	Rab3A	PANTR|Ensembl=ENSPTRG00000010697|UniProtKB=H2QFS9	RAB3A, member RAS oncogene family	ISS	9194562	PubMed	PTHR24073:SF532	RAS-RELATED PROTEIN RAB-3A
P00018	EGF receptor signaling pathway	P00556	PLCgamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IGI	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	10218114	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	IC	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00047	PDGF signaling pathway	P01148	Grb2	MACMU|Ensembl=ENSMMUG00000004880|UniProtKB=F7AN37	GRB2-related adapter protein 2	ISS	10021361	PubMed	PTHR24418:SF299	GRB2-RELATED ADAPTER PROTEIN 2
P04398	p53 pathway feedback loops 2	P04657	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01230	Src kinase	RAT|RGD=2641|UniProtKB=Q62844	Tyrosine-protein kinase Fyn	IDA	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	CANLF|Ensembl=ENSCAFG00000004381|UniProtKB=J9JH96	Uncharacterized protein	ISS	8314195	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	PANTR|Ensembl=ENSPTRG00000008102|UniProtKB=H2QB29	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	ORNAN|Ensembl=ENSOANG00000013097|UniProtKB=F6UVN1	Uncharacterized protein	ISS	600075	OMIM	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00029	Huntington disease	P00807	Actin	BOVIN|Ensembl=ENSBTAG00000014614|UniProtKB=P62739	Actin, aortic smooth muscle	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00034	Integrin signalling pathway	P00951	Jnk	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IDA	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01143	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05912	Dopamine receptor mediated signaling pathway	P05970	TH	RAT|RGD=3853|UniProtKB=P04177	Tyrosine 3-monooxygenase	ISS	12480184	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04397	p53 pathway by glucose deprivation	P04641	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00586	Gq	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00318	PKCs	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IDA	8132661	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PHYPA|Gene=PHYPADRAFT_117822|UniProtKB=A9RQS1	Predicted protein	ISS	12932731	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P05913	Enkephalin release	P05972	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01428	Frizzled	XENTR|Xenbase=XB-GENE-484322|UniProtKB=F6RPG1	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF22	FRIZZLED-3
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	HUMAN|HGNC=1952|UniProtKB=P20309	Muscarinic acetylcholine receptor M3	IDA	8100450	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00015	Circadian clock system	P00505	Cry	MONDO|Ensembl=ENSMODG00000001579|UniProtKB=F7BWW8	Uncharacterized protein	ISS	10428031	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	DANRE|ZFIN=ZDB-GENE-051202-1|UniProtKB=E7F101	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF2	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00951	Jnk	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P06213	DPP signaling pathway	P06291	DAD	DROME|FlyBase=FBgn0020493|UniProtKB=Q5U110	Mothers against decapentaplegic homolog	IEA	9335505	PubMed	PTHR13703:SF44	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG
P00036	Interleukin signaling pathway	P00967	c-fos	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00012	Cadherin signaling pathway	P00471	Cadherin	ANOGA|EnsemblGenome=AGAP003579|UniProtKB=Q7QAQ8	AGAP003579-PA	ISS	8120095	PubMed	PTHR43956:SF8	CADHERIN 88C-RELATED
P00057	Wnt signaling pathway	P01455	Smad4	DROME|FlyBase=FBgn0011648|UniProtKB=P42003	Protein mothers against dpp	IDA	12736218	PubMed	PTHR13703:SF40	PROTEIN MOTHERS AGAINST DPP
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00049	Parkinson disease	P01238	14-3-3	PANTR|Ensembl=ENSPTRG00000013529|UniProtKB=H2R8X6	Uncharacterized protein	ISS	12618428	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	MONDO|Ensembl=ENSMODG00000007421|UniProtKB=F6XBV3	Uncharacterized protein	ISS	15858232	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	11832947	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00048	PI3 kinase pathway	P01177	P110ACT	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00269	MAPK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00021	FGF signaling pathway	P00629	PP2A	MACMU|Ensembl=ENSMMUG00000019771|UniProtKB=F7APV7	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform 1	ISS	10092233	PubMed	PTHR10257:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01309	fos	BOVIN|Ensembl=ENSBTAG00000004322|UniProtKB=O77628	Proto-oncogene c-Fos	TAS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00057	Wnt signaling pathway	P01465	Ggamma	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	IDA	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04392	P53 pathway feedback loops 1	P04539	p53	HUMAN|HGNC=11998|UniProtKB=P04637	Cellular tumor antigen p53	TAS	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P05913	Enkephalin release	P05974	G-Protein (i)	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000004474|UniProtKB=E2RCN6	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P05915	Opioid proenkephalin pathway	P05994	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04452	proopiomelanocortin	PANTR|Ensembl=ENSPTRG00000011721|UniProtKB=H2R8Y3	Uncharacterized protein	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00047	PDGF signaling pathway	P01151	PKB	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MACMU|Ensembl=ENSMMUG00000000223|UniProtKB=F6XHK8	Uncharacterized protein	ISS			PTHR24247:SF33	5-HYDROXYTRYPTAMINE RECEPTOR 1E
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	IC	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MACMU|Ensembl=ENSMMUG00000016675|UniProtKB=F6VTB5	Uncharacterized protein	ISS	11319238	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00015	Circadian clock system	G01500	bmal1	CANLF|Ensembl=ENSCAFG00000008095|UniProtKB=J9NTT7	Uncharacterized protein	ISS	11163178	PubMed	PTHR23042:SF52	ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 1
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CANLF|Ensembl=ENSCAFG00000007782|UniProtKB=F1PWZ2	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF358	MYOSIN-7B
P04396	Vitamin D metabolism and pathway	P04601	25-Hydroxylase	MACMU|Ensembl=ENSMMUG00000022144|UniProtKB=F7H3A6	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	ISS	11013342	PubMed	PTHR24291:SF3	25-HYDROXYVITAMIN D-1 ALPHA HYDROXYLASE, MITOCHONDRIAL
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	88241036	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00859	NFkappaB	MOUSE|MGI=MGI=97897|UniProtKB=P15307	Proto-oncogene c-Rel	IDA	11884420	PubMed	PTHR24169:SF4	PROTO-ONCOGENE C-REL
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=98960|UniProtKB=P22727	Protein Wnt-6	IDA	8717036	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00718	Phosphorylase a	BOVIN|Gene=PYGM|UniProtKB=P79334	Glycogen phosphorylase, muscle form	IDA	4318782	PubMed	PTHR11468:SF13	GLYCOGEN PHOSPHORYLASE, MUSCLE FORM
P00005	Angiogenesis	P00206	Wnt	MACMU|Ensembl=ENSMMUG00000009980|UniProtKB=F6R3A1	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P02729	Ascorbate degradation	P02852	L-xylulose-5-phosphate-3-epimerase	ORYSJ|EnsemblGenome=OS03G0169100|UniProtKB=Q9ZTP5	Ribulose-phosphate 3-epimerase, chloroplastic	ISS			PTHR11749:SF4	D-RIBULOSE-5-PHOSPHATE-3-EPIMERASE
P00047	PDGF signaling pathway	P01151	PKB	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	PANTR|Ensembl=ENSPTRG00000011756|UniProtKB=H2QHM0	Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	ISS			PTHR11405:SF5	CAD PROTEIN
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	ARATH|TAIR=AT3G08510|UniProtKB=Q39033	Phosphoinositide phospholipase C 2	ISS			PTHR10336:SF92	PHOSPHOINOSITIDE PHOSPHOLIPASE C 2-RELATED
P00025	Hedgehog signaling pathway	P00699	Su(fu)	RAT|RGD=1559462|UniProtKB=Q4V8C6	Suppressor of fused homolog	ISS	12068298	PubMed	PTHR10928:SF2	SUPPRESSOR OF FUSED HOMOLOG
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00046	Oxidative stress response	P01129	JNK1/2	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00052	TGF-beta signaling pathway	P01286	TGFbeta	RAT|RGD=1305979|UniProtKB=D4A7P9	Protein Bmp5	ISS	9759503	PubMed	PTHR11848:SF139	BONE MORPHOGENETIC PROTEIN 5
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05974	G-Protein (i)	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=99879|UniProtKB=Q62101	Serine/threonine-protein kinase D1	ISS	8078925	PubMed	PTHR22968:SF9	SERINE/THREONINE-PROTEIN KINASE D1
P00030	Hypoxia response via HIF activation	P00819	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	YEAST|SGD=S000000358|UniProtKB=P20434	DNA-directed RNA polymerases I, II, and III subunit RPABC1	IGI	93255907	PubMed	PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P04375	5HT3 type receptor mediated signaling pathway	P04425	K+ channel	HUMAN|HGNC=6283|UniProtKB=Q9NPC2	Potassium channel subfamily K member 9	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00057	Wnt signaling pathway	P01438	PP2A	XENTR|Xenbase=XB-GENE-484003|UniProtKB=Q6P365	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00554	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	7798194	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00006	Apoptosis signaling pathway	P00292	IkappaB	HUMAN|HGNC=7797|UniProtKB=P25963	NF-kappa-B inhibitor alpha	ISS	14665694	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	IGI	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	PANTR|Ensembl=ENSPTRG00000014976|UniProtKB=H2R892	Uncharacterized protein	ISS	20012997	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	HUMAN|HGNC=12441|UniProtKB=P04818	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00852	PYK2	MONDO|Ensembl=ENSMODG00000015932|UniProtKB=F6Z395	Uncharacterized protein	ISS	12640026	PubMed	PTHR24418:SF94	PROTEIN-TYROSINE KINASE 2-BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PUCGT|EnsemblGenome=PGTG_12204|UniProtKB=E3KPL3	Tubulin beta chain	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00274	JNK	CAEEL|WormBase=WBGene00013091|UniProtKB=Q9XXC0	Uncharacterized protein	ISS			PTHR24055:SF253	SUBFAMILY NOT NAMED
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	DICDI|dictyBase=DDB_G0273069|UniProtKB=P22887	Nucleoside diphosphate kinase, cytosolic	ISS			PTHR11349:SF64	NUCLEOSIDE DIPHOSPHATE KINASE HOMOLOG 5
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00010	B cell activation	P00388	PLC gamma2	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00754	PDEgamma	CANLF|Ensembl=ENSCAFG00000005767|UniProtKB=P54827	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	TAS	P54827	SPACC	PTHR12122:SF4	RETINAL ROD RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT GAMMA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	IC	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00059	p53 pathway	P04609	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00996	STAT	HUMAN|HGNC=11367|UniProtKB=P51692	Signal transducer and activator of transcription 5B	IDA	96210005	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00968	Ikk	CANLF|Ensembl=ENSCAFG00000005526|UniProtKB=E2RKR0	Uncharacterized protein	ISS	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00059	p53 pathway	P01484	Chk2	RAT|RGD=621543|UniProtKB=Q9R019	CHK2 checkpoint homolog (S. pombe), isoform CRA_a	IGI	12356735	PubMed	PTHR44167:SF1	SERINE/THREONINE-PROTEIN KINASE CHK2
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00029	Huntington disease	P00776	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MONDO|Ensembl=ENSMODG00000008826|UniProtKB=F6XUU0	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P00053	T cell activation	P01300	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	3755548	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00010	B cell activation	P00381	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000016759|UniProtKB=H2QQP8	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF99	CADHERIN-9
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	MOUSE|MGI=MGI=99460|UniProtKB=Q61982	Neurogenic locus notch homolog protein 3	IDA	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00005	Angiogenesis	P00221	JNK1	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05731	GABA-B receptor II signaling	P05755	Gbeta	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00057	Wnt signaling pathway	P01448	CBP	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	14526383	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00056	VEGF signaling pathway	P01425	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05916	Opioid prodynorphin pathway	P06002	G-protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	TAS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P06959	CCKR signaling map	P07138	SHC1	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	RCA	8760305	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	IDA	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00024	Glycolysis	P00679	Aldolase	MONDO|Ensembl=ENSMODG00000015696|UniProtKB=F7E0Q7	Fructose-bisphosphate aldolase	ISS	4812352	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00056	VEGF signaling pathway	P01423	p38MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00053	T cell activation	P01311	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IDA	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DROME|FlyBase=FBgn0003093|UniProtKB=P13678	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	XENTR|Xenbase=XB-GENE-6050844|UniProtKB=F6WNJ9	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04398	p53 pathway feedback loops 2	P04665	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000010143|UniProtKB=F6QXA9	Uncharacterized protein	ISS	10644715	PubMed	PTHR24356:SF175	SERINE/THREONINE-PROTEIN KINASE N3
P00052	TGF-beta signaling pathway	P01284	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05731	GABA-B receptor II signaling	P05760	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	RCA	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00021	FGF signaling pathway	P00641	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	IDA	12471242	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	HUMAN|HGNC=10436|UniProtKB=P23443	Ribosomal protein S6 kinase beta-1	ISS	11861821	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00006	Apoptosis signaling pathway	P00261	Bok	ORNAN|Ensembl=ENSOANG00000005633|UniProtKB=F7AGS1	Uncharacterized protein	ISS	9356461	PubMed	PTHR11256:SF48	BCL-2-RELATED OVARIAN KILLER PROTEIN
P02759	Pyridoxal-5-phosphate biosynthesis	P03061	Pyridoxine-5-phosphate oxidase	STRCO|EnsemblGenome=CAB95898|UniProtKB=Q9K3V7	Pyridoxine/pyridoxamine 5'-phosphate oxidase	ISS	12000953	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01001	KA4	PANTR|Gene=GRIK4|UniProtKB=Q5IS46	Glutamate receptor ionotropic, kainate 4	ISS	12941441	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00048	PI3 kinase pathway	P01177	P110ACT	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	IGI	12660731	PubMed	PTHR10048:SF14	PI-3 KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	TAS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00036	Interleukin signaling pathway	P00983	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IC	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00204	PLD	MACMU|Ensembl=ENSMMUG00000023289|UniProtKB=F7FFD2	Uncharacterized protein	ISS	9307024	PubMed	PTHR18896:SF57	PHOSPHOLIPASE D1
P00047	PDGF signaling pathway	P01162	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00057	Wnt signaling pathway	P01452	NFAT	PANTR|Ensembl=ENSPTRG00000013628|UniProtKB=H2R4F5	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	TAS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04397	p53 pathway by glucose deprivation	G04706	TSC2	MACMU|Ensembl=ENSMMUG00000002808|UniProtKB=F7H034	Uncharacterized protein	ISS	15249583	PubMed	PTHR10063:SF0	TUBERIN
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	DANRE|ZFIN=ZDB-GENE-081003-1|UniProtKB=B0LK22	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P00045	Notch signaling pathway	P01110	Presenilin	CAEEL|WormBase=WBGene00004769|UniProtKB=P52166	Presenilin sel-12	IGI	7566091	PubMed	PTHR10202:SF13	PRESENILIN-2
P05913	Enkephalin release	P05972	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00514	MLCK	HUMAN|HGNC=16243|UniProtKB=Q9H1R3	Myosin light chain kinase 2, skeletal/cardiac muscle	TAS	600922	OMIM	PTHR45210:SF1	MYOSIN LIGHT CHAIN KINASE 2, SKELETAL/CARDIAC MUSCLE
P00021	FGF signaling pathway	P00643	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00928	alpha actinin	DICDI|dictyBase=DDB_G0268632|UniProtKB=P05095	Alpha-actinin A	IPI			PTHR43947:SF1	ALPHA-ACTININ, SARCOMERIC
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CAEEL|WormBase=WBGene00003850|UniProtKB=Q18434	Guanine nucleotide-binding protein alpha-17 subunit	ISS	12488551	PubMed	PTHR10218:SF215	GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-17 SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	DROME|FlyBase=FBgn0010051|UniProtKB=P29993	Inositol 1,4,5-trisphosphate receptor	IC	4262086	gi	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P02721	ATP synthesis	P02794	F1 beta	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g230667|UniProtKB=A7SPP0	ATP synthase subunit beta	ISS	2896550	PubMed	PTHR15184:SF44	ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL
P00057	Wnt signaling pathway	P01444	Wnt	DANRE|ZFIN=ZDB-GENE-980526-526|UniProtKB=P24257	Protein Wnt-1	IDA	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00016	Cytoskeletal regulation by Rho GTPase	P00521	Profilin	DICDI|dictyBase=DDB_G0271142|UniProtKB=Q8T8M2	Profilin-3	ISS			PTHR11604:SF0	PROFILIN
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IDA	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	RAT|RGD=1304854|UniProtKB=Q3B7L1	Pleckstrin homology domain-containing family H member 3	ISS			PTHR22903:SF17	PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY H MEMBER 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	HUMAN|HGNC=19663|UniProtKB=Q9UBI6	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	IDA	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00047	PDGF signaling pathway	P01170	PDGF	MOUSE|MGI=MGI=97528|UniProtKB=P31240	Platelet-derived growth factor subunit B	ISS			PTHR11633:SF2	PLATELET-DERIVED GROWTH FACTOR SUBUNIT B
P05730	Endogenous cannabinoid signaling	P05751	Galpha	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00060	Ubiquitin proteasome pathway	P01491	E2	RAT|RGD=619912|UniProtKB=P61078	Ubiquitin-conjugating enzyme E2 D3	ISS			PTHR24068:SF48	UBIQUITIN-CONJUGATING ENZYME E2 D3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	PANTR|Ensembl=ENSPTRG00000021047|UniProtKB=H2QXD7	Transducin-like enhancer of split 4	ISS	9783586	PubMed	PTHR10814:SF21	TRANSDUCIN-LIKE ENHANCER PROTEIN 4
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	TAS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06587	Nicotine pharmacodynamics pathway	P06605	KCNK3/9	MONDO|Ensembl=ENSMODG00000015769|UniProtKB=F6ZSC2	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00054	Toll receptor signaling pathway	P01376	Uev1A	HUMAN|HGNC=12494|UniProtKB=Q13404	Ubiquitin-conjugating enzyme E2 variant 1	ISS			PTHR43915:SF2	UBIQUITIN-CONJUGATING ENZYME E2 VARIANT 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	DROME|FlyBase=FBgn0010341|UniProtKB=P40793	Cdc42 homolog	ISS	4757952	gi	PTHR24072:SF192	CDC42 HOMOLOG
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00053	T cell activation	P01307	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IDA	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00034	Integrin signalling pathway	P00933	Crk	PANTR|Ensembl=ENSPTRG00000008522|UniProtKB=H2QBT8	Uncharacterized protein	ISS	8649368	PubMed	PTHR19969:SF8	ADAPTER MOLECULE CRK
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Ensembl=ENSBTAG00000013202|UniProtKB=Q1RML2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1	ISS	15611108	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P04374	5HT2 type receptor mediated signaling pathway	P04413	K+ channel	DANRE|ZFIN=ZDB-GENE-040724-171|UniProtKB=Q5TZ59	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P02729	Ascorbate degradation	P02852	L-xylulose-5-phosphate-3-epimerase	STRCO|EnsemblGenome=CAB76886|UniProtKB=Q9L0Z5	Ribulose-phosphate 3-epimerase	ISS			PTHR11749:SF3	RIBULOSE-PHOSPHATE 3-EPIMERASE
P05917	Opioid proopiomelanocortin pathway	P06007	alpha-MSH	XENTR|Xenbase=XB-GENE-483703|UniProtKB=Q5M8F2	Proopiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02768	Proline biosynthesis	P03112	Glutamate semialdehyde dehydrogenase	BACSU|EnsemblGenome=BSU13130|UniProtKB=P39821	Gamma-glutamyl phosphate reductase	ISS			PTHR11063:SF8	DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01315	Calcineurin	MACMU|Ensembl=ENSMMUG00000004599|UniProtKB=F6Q932	Serine/threonine-protein phosphatase	ISS	12091710	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00060	Ubiquitin proteasome pathway	P01490	E3	MONDO|Ensembl=ENSMODG00000002655|UniProtKB=F7DI62	E3 ubiquitin-protein ligase	ISS			PTHR11254:SF396	NEDD4-LIKE E3 UBIQUITIN-PROTEIN LIGASE WWP2
P00006	Apoptosis signaling pathway	P00269	MAPK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00589	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	RCA	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05917	Opioid proopiomelanocortin pathway	P06010	proopiomelanocortin	DANRE|ZFIN=ZDB-GENE-030513-2|UniProtKB=Q7ZT18	Pro-opiomelanocortin protein	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00859	NFkappaB	RAT|RGD=1307189|UniProtKB=Q5U2Z4	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	ISS	9133421	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00054	Toll receptor signaling pathway	P01364	TPL2	PANTR|Ensembl=ENSPTRG00000002400|UniProtKB=H2Q1S6	Mitogen-activated protein kinase kinase kinase 8	ISS	92019818	PubMed	PTHR24361:SF94	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 8
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	NAS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00037	Ionotropic glutamate receptor pathway	P01020	NSF	DICDI|dictyBase=DDB_G0276153|UniProtKB=Q75JI3	Vesicle-fusing ATPase	ISS	11348590	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=3346|UniProtKB=P10688	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	12860966	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P02742	Tetrahydrofolate biosynthesis	P02944	Phosphoribosylglycinamide formyltransferase	AQUAE|EnsemblGenome=aq_1818|UniProtKB=O67681	Formyltetrahydrofolate deformylase	ISS			PTHR42706:SF1	FORMYLTETRAHYDROFOLATE DEFORMYLASE 1, MITOCHONDRIAL-RELATED
P00057	Wnt signaling pathway	P01452	NFAT	MACMU|Ensembl=ENSMMUG00000012657|UniProtKB=F7E7J1	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01143	ERK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02738	De novo purine biosynthesis	P02894	IMP cyclohydrolase	FUSNN|EnsemblGenome=FN0982|UniProtKB=Q8REV6	Bifunctional purine biosynthesis protein PurH	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=13829|UniProtKB=Q9GZT5	Protein Wnt-10a	IDA	8717036	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00029	Huntington disease	P00785	Cytochrome c	CHLRE|EnsemblGenome=CHLREDRAFT_133395|UniProtKB=A8JIU5	Ubiquinol:cytochrome c oxidoreductase cytochrome c1	IDA	15163634	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P02743	Formyltetrahydroformate biosynthesis	P02952	Methylene tetrahydrofolate dehydrogenase	ORYSJ|Gene=Os05g0150800|UniProtKB=Q5WN02	Os05g0150800 protein	ISS			PTHR10025:SF33	METHENYL TETRAHYDROFOLATE CYCLOHYDROLASE / NADP-DEPENDENT METHYLENE H4F DEHYDROGENASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00056	VEGF signaling pathway	P01413	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00229	SPK	MOUSE|MGI=MGI=1316649|UniProtKB=Q8CI15	Sphingosine kinase 1	ISS			PTHR12358:SF47	SPHINGOSINE KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	MACMU|Ensembl=ENSMMUG00000014334|UniProtKB=F7CYY6	Uncharacterized protein	ISS	1319557	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00005	Angiogenesis	P00205	GAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	20908895	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00020	FAS signaling pathway	P00614	ASK1	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	TAS			PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01129	JNK1/2	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00020	FAS signaling pathway	P00612	Fas	HUMAN|HGNC=11920|UniProtKB=P25445	Tumor necrosis factor receptor superfamily member 6	TAS	14676844	PubMed	PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P00034	Integrin signalling pathway	P00928	alpha actinin	CANLF|Ensembl=ENSCAFG00000005776|UniProtKB=E2R5T9	Uncharacterized protein	ISS	2116421	PubMed	PTHR43947:SF7	ALPHA-ACTININ-4
P02774	Salvage pyrimidine deoxyribonucleotides	P03147	Thymidine kinase	PANTR|Ensembl=ENSPTRG00000009704|UniProtKB=H2QDZ3	Thymidine kinase	ISS			PTHR11441:SF0	THYMIDINE KINASE, CYTOSOLIC
P05916	Opioid prodynorphin pathway	P06002	G-protein	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IC	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	ARATH|TAIR=AT5G26751|UniProtKB=P43288	Shaggy-related protein kinase alpha	IDA			PTHR24057:SF13	SHAGGY-RELATED PROTEIN KINASE ALPHA-RELATED
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	RAT|RGD=2732|UniProtKB=P22756	Glutamate receptor ionotropic, kainate 1	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04393	Ras Pathway	P04546	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	RAT|RGD=2742|UniProtKB=P23385	Metabotropic glutamate receptor 1	IDA	7476890	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00057	Wnt signaling pathway	P01444	Wnt	CAEEL|WormBase=WBGene00001188|UniProtKB=G5EG05	Uncharacterized protein	IDA	8717036	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P00009	Axon guidance mediated by netrin	P00366	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00019	Endothelin signaling pathway	P00590	IP3 R	RAT|RGD=69649|UniProtKB=P29995	Inositol 1,4,5-trisphosphate receptor type 2	IGI	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00021	FGF signaling pathway	P00644	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	ANOGA|EnsemblGenome=AGAP006027|UniProtKB=Q7PNT0	AGAP006027-PA	ISS	12941441	PubMed	PTHR18966:SF270	GLUTAMATE RECEPTOR 1-RELATED
P00005	Angiogenesis	P00231	HSP27	CHICK|Ensembl=ENSGALG00000007945|UniProtKB=Q05713	Alpha-crystallin B chain	ISS			PTHR11527:SF37	ALPHA-CRYSTALLIN B CHAIN
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DANRE|ZFIN=ZDB-GENE-040625-35|UniProtKB=Q6IQL9	Novel actin protein	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00057	Wnt signaling pathway	P01447	Dishevelled	RAT|RGD=1308834|UniProtKB=D4ADV8	Protein Dvl3	ISS	10409711	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P00034	Integrin signalling pathway	P00914	Filamin	CHICK|Ensembl=ENSGALG00000005678|UniProtKB=F1N8D4	Uncharacterized protein	IPI	9722563	PubMed	PTHR43998:SF3	FILAMIN-B
P00005	Angiogenesis	P00244	MAPKAPK2/3	DROME|FlyBase=FBgn0013987|UniProtKB=P49071	MAP kinase-activated protein kinase 2	ISS			PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01311	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	IEA	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00047	PDGF signaling pathway	P01164	PDK1/2	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	ISS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00005	Angiogenesis	P00193	SOS-1	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00005	Angiogenesis	P00249	PAK	BOVIN|Ensembl=ENSBTAG00000010191|UniProtKB=Q08E52	Serine/threonine-protein kinase PAK 1	ISS	14580336	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000010393|UniProtKB=F7D992	Uncharacterized protein	ISS	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P04397	p53 pathway by glucose deprivation	P04641	Akt	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	ISS	12719720	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00233	CSL	HUMAN|HGNC=13761|UniProtKB=Q9UBG7	Recombining binding protein suppressor of hairless-like protein	ISS			PTHR10665:SF2	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS-LIKE PROTEIN
P05913	Enkephalin release	P05974	G-Protein (i)	MACMU|Ensembl=ENSMMUG00000017374|UniProtKB=F7H6T7	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00056	VEGF signaling pathway	P01407	Erk	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02743	Formyltetrahydroformate biosynthesis	P02952	Methylene tetrahydrofolate dehydrogenase	DEIRA|EnsemblGenome=DR_0867|UniProtKB=Q9RW02	Bifunctional protein FolD	ISS			PTHR10025:SF46	BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, MITOCHONDRIAL
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00060	Ubiquitin proteasome pathway	P01492	E1	NEUCR|EnsemblGenome=EFNCRG00000002730|UniProtKB=V5IMY0	Ubiquitin-activating enzyme E1 3	ISS			PTHR10953:SF5	SUMO-ACTIVATING ENZYME SUBUNIT 2
P00021	FGF signaling pathway	P00642	MEK1-2	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01080	AChE	BOVIN|Gene=ACHE|UniProtKB=P23795	Acetylcholinesterase	IC			PTHR43142:SF1	CARBOXYLIC ESTER HYDROLASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06812	L-type Ca2+	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	RCA	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	MONDO|Ensembl=ENSMODG00000016960|UniProtKB=F6V5G0	Uncharacterized protein	ISS	20012997	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P02762	Pentose phosphate pathway	P03080	Glucose-P-Isomerase	MACMU|Ensembl=ENSMMUG00000005880|UniProtKB=F6TLQ6	Glucose-6-phosphate isomerase	ISS	2248981	PubMed	PTHR11469:SF4	GLUCOSE-6-PHOSPHATE ISOMERASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	SCHMA|EnsemblGenome=Smp_161920|UniProtKB=G4VSW5	Putative actin	IC	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P04393	Ras Pathway	P04567	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	HUMAN|HGNC=9994|UniProtKB=O14924	Regulator of G-protein signaling 12	IDA	8756726	PubMed	PTHR10845:SF149	REGULATOR OF G-PROTEIN SIGNALING 12
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	HUMAN|HGNC=9508|UniProtKB=P49768	Presenilin-1	IDA	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00018	EGF receptor signaling pathway	P00562	p38	DROME|FlyBase=FBgn0015765|UniProtKB=O62618	Mitogen-activated protein kinase 14A	IGI	10851062	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00034	Integrin signalling pathway	P00922	Collagen	HUMAN|HGNC=2186|UniProtKB=P12107	Collagen alpha-1(XI) chain	IDA	10778855	PubMed	PTHR24023:SF42	COLLAGEN ALPHA-1 XI  CHAIN
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04485	H1	PANTR|Gene=HRH1|UniProtKB=Q9N2B2	Histamine H1 receptor	ISS	2670975	PubMed	PTHR43914:SF2	HISTAMINE H1 RECEPTOR
P00019	Endothelin signaling pathway	P00591	PLCbeta	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	IGI	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00049	Parkinson disease	P01219	SAPK	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00018	EGF receptor signaling pathway	P00539	14-3-3	MONDO|Ensembl=ENSMODG00000010174|UniProtKB=F6TA21	Uncharacterized protein	ISS	12917326	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00057	Wnt signaling pathway	P01465	Ggamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00059	p53 pathway	P04623	CBP	MOUSE|MGI=MGI=1276116|UniProtKB=B2RWS6	Histone acetyltransferase p300	ISS	10823891	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00009	Axon guidance mediated by netrin	P00360	DCC/UNC-40	MACMU|Ensembl=ENSMMUG00000013999|UniProtKB=F6RRI0	Uncharacterized protein	ISS	12798294	PubMed	PTHR44146:SF3	NETRIN RECEPTOR DCC
P00006	Apoptosis signaling pathway	P00296	DAXX	RAT|RGD=621227|UniProtKB=Q8VIB2	Death domain-associated protein 6	ISS	9215629	PubMed	PTHR12766:SF7	DEATH DOMAIN-ASSOCIATED PROTEIN 6
P00011	Blood coagulation	P00406	Fibrinogen	PANTR|Ensembl=ENSPTRG00000016536|UniProtKB=H2RDH7	Uncharacterized protein	ISS	80015086	PubMed	PTHR19143:SF338	FIBRINOGEN GAMMA CHAIN
P00047	PDGF signaling pathway	P01161	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	DICPU|Gene=DICPUDRAFT_91511|UniProtKB=F0ZDJ1	Serine/threonine-protein phosphatase	ISS	99379588	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	THEMA|EnsemblGenome=TM_1479|UniProtKB=Q9X1I8	Adenylate kinase	ISS			PTHR23359:SF22	GTP:AMP PHOSPHOTRANSFERASE, MITOCHONDRIAL
P05913	Enkephalin release	P05974	G-Protein (i)	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00029	Huntington disease	P00807	Actin	MONDO|Ensembl=ENSMODG00000008826|UniProtKB=F6XUU0	Uncharacterized protein	ISS			PTHR11937:SF240	SUBFAMILY NOT NAMED
P00054	Toll receptor signaling pathway	G01550	Gene trancription	HUMAN|HGNC=5986|UniProtKB=Q14116	Interleukin-18	ISS	11331040	PubMed	PTHR45200:SF1	INTERLEUKIN-18
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00047	PDGF signaling pathway	P01150	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00034	Integrin signalling pathway	P00931	Integrin beta	HUMAN|HGNC=6160|UniProtKB=P18084	Integrin beta-5	IDA	3487386	PubMed	PTHR10082:SF26	INTEGRIN BETA-5
P00019	Endothelin signaling pathway	P00566	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MACMU|Ensembl=ENSMMUG00000014597|UniProtKB=F6VAQ6	Glycogen synthase kinase-3 alpha	ISS	183955	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05945	Gsalpha	CHICK|Ensembl=ENSGALG00000007509|UniProtKB=F1NM72	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	IC	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00005	Angiogenesis	P00211	GSK3beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00019	Endothelin signaling pathway	P00591	PLCbeta	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IGI	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00021	FGF signaling pathway	P00633	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	DEIRA|EnsemblGenome=DR_A0154|UniProtKB=Q9RYZ9	Glucosamine--fructose-6-phosphate aminotransferase	ISS			PTHR10937:SF8	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CAEBR|Gene=CBG05858|UniProtKB=A8X1H0	Protein CBR-EGL-19 (Fragment)	ISS	10514528	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00052	TGF-beta signaling pathway	P01275	P38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	TAS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	CANLF|Ensembl=ENSCAFG00000016387|UniProtKB=E2QV83	Uncharacterized protein	ISS	12145413	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00044	Nicotinic acetylcholine receptor signaling pathway	P01098	CHT1	ANOGA|EnsemblGenome=AGAP002366|UniProtKB=Q7QBY8	AGAP002366-PA	RCA			PTHR11819:SF12	HIGH-AFFINITY CHOLINE TRANSPORTER 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	HUMAN|HGNC=10432|UniProtKB=P51812	Ribosomal protein S6 kinase alpha-3	ISS	2779569	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00045	Notch signaling pathway	P01099	Notch	HUMAN|HGNC=7881|UniProtKB=P46531	Neurogenic locus notch homolog protein 1	IGI	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	TAS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04393	Ras Pathway	P04546	GSK3	MACMU|Ensembl=ENSMMUG00000014597|UniProtKB=F6VAQ6	Glycogen synthase kinase-3 alpha	ISS	2164470	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	LEIMA|EnsemblGenome=LmjF.35.4010|UniProtKB=Q9GNR4	Protein kinase A catalytic subunit isoform 1	ISS	10218114	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	XENTR|Xenbase=XB-GENE-489917|UniProtKB=Q07FZ4	C-X-C chemokine receptor type 4	ISS	4503175	gi	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P00019	Endothelin signaling pathway	P00591	PLCbeta	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IC	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	MOUSE|MGI=MGI=95810|UniProtKB=Q9Z2W9	Glutamate receptor 3	ISS	12871085	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00017	DNA replication	P00527	Histones	DROME|FlyBase=FBgn0001199|UniProtKB=P02299	Histone H3	ISS	20448842	PubMed	PTHR11426:SF20	HISTONE H3-LIKE CENTROMERIC PROTEIN A
P00047	PDGF signaling pathway	P01154	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IGI	12707323	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00005	Angiogenesis	P00254	GTPase	XENTR|Xenbase=XB-GENE-941426|UniProtKB=Q28HZ4	Novel Rho protein	ISS	10556059	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00019	Endothelin signaling pathway	P00577	PI3K	NEUCR|EnsemblGenome=EFNCRG00000000622|UniProtKB=Q7SHZ6	Phosphoinositide 3-kinase	ISS			PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05925	beta-ARR1	BOVIN|Ensembl=ENSBTAG00000020485|UniProtKB=P17870	Beta-arrestin-1	RCA	4757780	gi	PTHR11792:SF22	BETA-ARRESTIN-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	IC	3755548	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05916	Opioid prodynorphin pathway	P06002	G-protein	XENTR|Xenbase=XB-GENE-956713|UniProtKB=Q5XGD8	Guanine nucleotide binding protein, beta 3	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00034	Integrin signalling pathway	P00941	Integrin alpha	RAT|RGD=2923|UniProtKB=P18614	Integrin alpha-1	IPI	3487386	PubMed	PTHR23220:SF22	INTEGRIN ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	IDA	15737619	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	CHICK|Ensembl=ENSGALG00000003498|UniProtKB=Q5ZMS1	Transcription initiation factor TFIID subunit 8	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00025	Hedgehog signaling pathway	P00691	CBP	CANLF|Ensembl=ENSCAFG00000019251|UniProtKB=F1PY87	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00023	General transcription regulation	P00658	TBP-associated factors	DROME|FlyBase=FBgn0000617|UniProtKB=Q27272	Transcription initiation factor TFIID subunit 9	ISS			PTHR12595:SF6	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 9
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	IPI	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00005	Angiogenesis	P00219	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MOUSE|MGI=MGI=103567|UniProtKB=Q04683	C-X-C chemokine receptor type 5	TAS	12101256	PubMed	PTHR10489:SF618	C-X-C CHEMOKINE RECEPTOR TYPE 5
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	ORNAN|Ensembl=ENSOANG00000015652|UniProtKB=F7FY70	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	TAS	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00029	Huntington disease	P00790	beta-Tubulin	CHICK|GeneID=396254|UniProtKB=P09244	Tubulin beta-7 chain	TAS	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04398	p53 pathway feedback loops 2	P04661	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01415	MAPKAPK2/3	MOUSE|MGI=MGI=2143163|UniProtKB=Q3UMW7	MAP kinase-activated protein kinase 3	ISS	11157753	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CAEEL|WormBase=WBGene00003232|UniProtKB=Q09630	Probable metabotropic glutamate receptor mgl-1	IDA	12351712	PubMed	PTHR24060:SF137	METABOTROPIC GLUTAMATE RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00223	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CHICK|Ensembl=ENSGALG00000002098|UniProtKB=F1P0L4	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00053	T cell activation	P01306	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	RAT|RGD=2035|UniProtKB=Q03343	Adenylate cyclase type 6	IC	93028552	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00029	Huntington disease	P00778	NMDA receptor	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04393	Ras Pathway	P04555	PDK	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	9094314	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	TAS	12471242	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00010	B cell activation	P00378	SHP-1	HUMAN|HGNC=9658|UniProtKB=P29350	Tyrosine-protein phosphatase non-receptor type 6	TAS	14525967	PubMed	PTHR19134:SF65	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 6
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2744|UniProtKB=P31422	Metabotropic glutamate receptor 3	IDA	12351712	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	PANTR|Ensembl=ENSPTRG00000020202|UniProtKB=H2QW34	Uncharacterized protein	ISS	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00029	Huntington disease	P00805	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05915	Opioid proenkephalin pathway	P05994	G-protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=69424|UniProtKB=Q99P84	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	10934033	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	TETTS|EnsemblGenome=TTHERM_00193849|UniProtKB=A4VDR4	Conjugation stage-specific protein	ISS	2187864	PubMed	PTHR11800:SF2	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P06217	Toll pathway-drosophila	P06346	MyD88	DROME|FlyBase=FBgn0033402|UniProtKB=Q7K105	LD20892p	ISS			PTHR15079:SF3	MYELOID DIFFERENTIATION PRIMARY RESPONSE PROTEIN MYD88
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P02751	Lysine biosynthesis	P03009	Aspartokinase	BACSU|EnsemblGenome=BSU28470|UniProtKB=P08495	Aspartokinase 2	ISS			PTHR21499:SF3	ASPARTOKINASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00030	Hypoxia response via HIF activation	P00824	PTEN	XENTR|Xenbase=XB-GENE-491433|UniProtKB=B1H2U0	Pten protein	ISS	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04393	Ras Pathway	P04541	p90RSK	MACMU|Ensembl=ENSMMUG00000022111|UniProtKB=F7H7W3	Ribosomal protein S6 kinase	ISS	2779569	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00025	Hedgehog signaling pathway	P00682	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00025	Hedgehog signaling pathway	P00692	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02772	Pyruvate metabolism	P03140	Pyruvate Carboxylase	MACMU|Ensembl=ENSMMUG00000004533|UniProtKB=F6SC45	Pyruvate carboxylase	ISS	12112657	PubMed	PTHR43778:SF2	PYRUVATE CARBOXYLASE, MITOCHONDRIAL
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MOUSE|MGI=MGI=87905|UniProtKB=P68033	Actin, alpha cardiac muscle 1	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04393	Ras Pathway	P04559	Rac	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04455	beta-endorphin	BOVIN|Ensembl=ENSBTAG00000007897|UniProtKB=P01190	Pro-opiomelanocortin	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00056	VEGF signaling pathway	P01425	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00036	Interleukin signaling pathway	P00994	FKHRL1	HUMAN|HGNC=3821|UniProtKB=O43524	Forkhead box protein O3	TAS	15031210	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IC	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04393	Ras Pathway	P04567	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	XENTR|Xenbase=XB-GENE-481916|UniProtKB=F6YF14	Presenilin	ISS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	BOVIN|Ensembl=ENSBTAG00000004775|UniProtKB=F1MBY1	Uncharacterized protein	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00011	Blood coagulation	P00450	Tissue Factor	MOUSE|MGI=MGI=88381|UniProtKB=P20352	Tissue factor	ISS	31560592	gi	PTHR20859:SF22	TISSUE FACTOR
P05913	Enkephalin release	P05976	Enkephalin	MOUSE|MGI=MGI=97535|UniProtKB=O35417	Proenkephalin-B	ISS	131330	OMIM	PTHR11438:SF4	PROENKEPHALIN-B
P00052	TGF-beta signaling pathway	P01286	TGFbeta	CHICK|Ensembl=ENSGALG00000016293|UniProtKB=F6UGL3	Uncharacterized protein	TAS	9759503	PubMed	PTHR11848:SF139	BONE MORPHOGENETIC PROTEIN 5
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IC	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	RAT|RGD=1311441|UniProtKB=A0A0G2K3B7	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00015	Circadian clock system	G01497	cry	MONDO|Ensembl=ENSMODG00000001579|UniProtKB=F7BWW8	Uncharacterized protein	ISS	14507900	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	HUMAN|HGNC=4403|UniProtKB=P61952	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	IC			PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P00018	EGF receptor signaling pathway	P00562	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IGI	4506085	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P02770	Pyridoxal phosphate salvage pathway	P03121	Pyridoxal kinase	ARATH|TAIR=AT5G37850|UniProtKB=Q8W1X2	Pyridoxal kinase	ISS	11910005	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P00046	Oxidative stress response	P01135	p38	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	TAS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	BOVIN|Ensembl=ENSBTAG00000009269|UniProtKB=F1MCM2	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P05915	Opioid proenkephalin pathway	P05994	G-protein	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT3G14720|UniProtKB=Q9LUC3	Mitogen-activated protein kinase 19	ISS	176948	OMIM	PTHR24055:SF200	MITOGEN-ACTIVATED PROTEIN KINASE 18-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00018	EGF receptor signaling pathway	P00565	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	IGI	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00047	PDGF signaling pathway	P01145	c-fos	CANLF|Ensembl=ENSCAFG00000017040|UniProtKB=E2QYK5	Uncharacterized protein	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	HUMAN|HGNC=5465|UniProtKB=P08069	Insulin-like growth factor 1 receptor	TAS	2877871	PubMed	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00014	Cholesterol biosynthesis	P00496	Diphosphomevalonate decarboxylase	YEAST|SGD=S000005326|UniProtKB=P32377	Diphosphomevalonate decarboxylase	ISS	4505289	gi	PTHR10977:SF3	DIPHOSPHOMEVALONATE DECARBOXYLASE
P00059	p53 pathway	G04689	Cyclin G	MACMU|Ensembl=ENSMMUG00000019550|UniProtKB=F7CKQ1	Uncharacterized protein	ISS	7957050	PubMed	PTHR10177:SF59	CYCLIN-G1
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00018	EGF receptor signaling pathway	P00551	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IGI	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	TAKRU|Ensembl=ENSTRUG00000015938|UniProtKB=H2UUX5	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	PANTR|Ensembl=ENSPTRG00000013244|UniProtKB=H2QJY6	Uncharacterized protein	ISS			PTHR24361:SF183	SERINE/THREONINE-PROTEIN KINASE PAK 7
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00705	Gsalpha	BOVIN|Ensembl=ENSBTAG00000002125|UniProtKB=F1N461	Uncharacterized protein	ISS	2106672	PubMed	PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01152	RasGAP	PANTR|Ensembl=ENSPTRG00000019540|UniProtKB=H2R524	Uncharacterized protein	ISS	6635197	gi	PTHR10194:SF4	RAS GTPASE-ACTIVATING PROTEIN 4-RELATED
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IGI	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00047	PDGF signaling pathway	P01145	c-fos	CANLF|Ensembl=ENSCAFG00000017040|UniProtKB=E2QYK5	Uncharacterized protein	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00029	Huntington disease	P00807	Actin	DANRE|ZFIN=ZDB-GENE-000322-1|UniProtKB=Q9I8V1	Actin, alpha 1, skeletal muscle	IDA	10974003	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P02750	Lipoate_biosynthesis	P03004	Lipoate synthase	SYNY3|EnsemblGenome=BAA16999|UniProtKB=P72980	Lipoyl synthase 1	ISS			PTHR10949:SF24	LIPOYL SYNTHASE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05918	p38 MAPK pathway	P06031	p38alpha	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	RCA	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00037	Ionotropic glutamate receptor pathway	P00999	PSD95	DROME|FlyBase=FBgn0040752|UniProtKB=A1Z9K8	LD13733p	ISS	20020275	PubMed	PTHR24135:SF18	LD13733P
P00020	FAS signaling pathway	P00620	CytochromeC	YEAST|SGD=S000005591|UniProtKB=P07143	Cytochrome c1, heme protein, mitochondrial	IGI	9027315	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P04393	Ras Pathway	P04557	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01443	Phospholipase C	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00017	DNA replication	P00527	Histones	RAT|RGD=621095|UniProtKB=P84245	Histone H3.3	ISS	12413958	PubMed	PTHR11426:SF166	HISTONE H3.3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00035	Interferon-gamma signaling pathway	P00954	Interferongamma	BOVIN|Ensembl=ENSBTAG00000012529|UniProtKB=P07353	Interferon gamma	TAS	11175845	PubMed	PTHR11419:SF0	INTERFERON GAMMA
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	BOVIN|Ensembl=ENSBTAG00000021013|UniProtKB=Q3ZBU7	Tubulin beta-4A chain	ISS	12932731	PubMed	PTHR11588:SF253	TUBULIN BETA-4A CHAIN
P00012	Cadherin signaling pathway	P00474	Wnt	BOVIN|Ensembl=ENSBTAG00000015364|UniProtKB=E1BEN9	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P04385	Histamine H1 receptor mediated signaling pathway	P04485	H1	HUMAN|HGNC=5182|UniProtKB=P35367	Histamine H1 receptor	ISS	11841575	PubMed	PTHR43914:SF2	HISTAMINE H1 RECEPTOR
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=4402|UniProtKB=P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04393	Ras Pathway	P04548	ATF2	BOVIN|Ensembl=ENSBTAG00000002295|UniProtKB=F1N177	Uncharacterized protein	ISS	10664585	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00021	FGF signaling pathway	P00627	ERK1-2	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	1178748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00021	FGF signaling pathway	P00629	PP2A	CANLF|Ensembl=ENSCAFG00000006453|UniProtKB=F6X958	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	CANLF|Ensembl=ENSCAFG00000007782|UniProtKB=F1PWZ2	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF358	MYOSIN-7B
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04393	Ras Pathway	P04578	Rho	CAEBR|Gene=CBG13664|UniProtKB=A8XIF5	Protein CBR-RHO-1	ISS	7798239	PubMed	PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	ANOGA|EnsemblGenome=AGAP006475|UniProtKB=Q5TQX0	AGAP006475-PA	ISS	4262086	gi	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	MOUSE|MGI=MGI=95810|UniProtKB=Q9Z2W9	Glutamate receptor 3	IC	12941441	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P04393	Ras Pathway	P04558	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IDA	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	MACMU|Ensembl=ENSMMUG00000012305|UniProtKB=F7DLC9	Tyrosine-protein kinase receptor	ISS	249616	gi	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	PANTR|Ensembl=ENSPTRG00000004964|UniProtKB=H2Q5Y6	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P00005	Angiogenesis	P00203	Erk	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01465	Ggamma	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	NEUCR|EnsemblGenome=EFNCRG00000005497|UniProtKB=Q8TG12	Casein kinase II subunit beta-1	IDA	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	RAT|RGD=2732|UniProtKB=P22756	Glutamate receptor ionotropic, kainate 1	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P05913	Enkephalin release	P05972	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05969	Protein Phosphatase-1	DROME|FlyBase=FBgn0003134|UniProtKB=P48461	Serine/threonine-protein phosphatase alpha-1 isoform	ISS	8392016	PubMed	PTHR11668:SF402	SERINE/THREONINE-PROTEIN PHOSPHATASE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	ISS	3487386	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	DANRE|Ensembl=ENSDARG00000071640|UniProtKB=E7F359	Uncharacterized protein	ISS			PTHR43893:SF9	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=894282|UniProtKB=O08858	Somatostatin receptor type 5	IDA	12441358	PubMed	PTHR24229:SF20	SOMATOSTATIN RECEPTOR TYPE 5
P04393	Ras Pathway	P04570	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	CANLF|Ensembl=ENSCAFG00000000178|UniProtKB=J9P315	Uncharacterized protein	ISS	11907044	PubMed	PTHR44025:SF2	PROLOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1
P04392	P53 pathway feedback loops 1	G04686	p73	RAT|RGD=1307083|UniProtKB=D4AA88	Protein Tp73	ISS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	RAT|RGD=3772|UniProtKB=P52631	Signal transducer and activator of transcription 3	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	PANTR|Ensembl=ENSPTRG00000004892|UniProtKB=H2Q5U3	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00183	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	8264585	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00018	EGF receptor signaling pathway	P00541	Spry	BOVIN|Gene=SPRY1|UniProtKB=A5D992	Protein sprouty homolog 1	ISS	98117253	PubMed	PTHR12365:SF10	PROTEIN SPROUTY HOMOLOG 1
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00007	Axon guidance mediated by semaphorins	P00334	PlexinA1	RAT|RGD=1560871|UniProtKB=D3Z981	Protein Plxna1	ISS	10520995	PubMed	PTHR22625:SF35	PLEXIN-A1
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00566	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06807	gnai	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	RCA	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00019	Endothelin signaling pathway	P00568	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00019	Endothelin signaling pathway	P00580	ET-RA/B	MOUSE|MGI=MGI=105923|UniProtKB=Q61614	Endothelin-1 receptor	ISS	91080923	PubMed	PTHR24243:SF31	ENDOTHELIN-1 RECEPTOR
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00590	IP3 R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-010705-1|UniProtKB=Q90Z40	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P02732	Coenzyme A linked carnitine metabolism	P02864	L-carnitine dehydratase	DROME|FlyBase=FBgn0038804|UniProtKB=Q9VDL4	LP04613p	ISS			PTHR43949:SF6	SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ORYSJ|EnsemblGenome=OS11G0163100|UniProtKB=Q67G20	Actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00006	Apoptosis signaling pathway	P00269	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MOUSE|MGI=MGI=97255|UniProtKB=Q02566	Myosin-6	ISS	10938134	PubMed	PTHR13140:SF721	MYOSIN-6
P00034	Integrin signalling pathway	P00920	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00833	RGS	MACMU|Ensembl=ENSMMUG00000005185|UniProtKB=F7CYN6	Uncharacterized protein	ISS	9774420	PubMed	PTHR10845:SF184	REGULATOR OF G-PROTEIN SIGNALING 4
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00251	cPLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	IDA	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00035	Interferon-gamma signaling pathway	P00956	SOCS	MONDO|Ensembl=ENSMODG00000023104|UniProtKB=F7AZP2	Uncharacterized protein	ISS	15032587	PubMed	PTHR44282:SF3	SUPPRESSOR OF CYTOKINE SIGNALING 5
P00046	Oxidative stress response	P01128	MEF-2	MACMU|Ensembl=ENSMMUG00000018122|UniProtKB=F7FGA1	Uncharacterized protein	ISS	11274345	PubMed	PTHR11945:SF145	MYOCYTE-SPECIFIC ENHANCER FACTOR 2A
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00034	Integrin signalling pathway	P00931	Integrin beta	CANLF|Ensembl=ENSCAFG00000003821|UniProtKB=E2RT60	Integrin beta	ISS	10706722	PubMed	PTHR10082:SF28	INTEGRIN BETA-1
P00004	Alzheimer disease-presenilin pathway	P00113	Erb-B4 transmembrane fragment	PANTR|Ensembl=ENSPTRG00000012883|UniProtKB=H2QJC5	Receptor protein-tyrosine kinase	ISS	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00019	Endothelin signaling pathway	P00568	PKC	SCHPO|PomBase=SPAC17G8.14c|UniProtKB=P36582	Protein kinase C-like 1	IGI	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00006	Apoptosis signaling pathway	P00269	MAPK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00029	Huntington disease	P00786	ARF	TAKRU|Ensembl=ENSTRUG00000014335|UniProtKB=H2UI79	Uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF294	ADP-RIBOSYLATION FACTOR 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	RAT|Ensembl=ENSRNOG00000059140|UniProtKB=A0A0G2K6E3	Protein Myo1g	ISS			PTHR13140:SF381	UNCONVENTIONAL MYOSIN-IG
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02762	Pentose phosphate pathway	P03070	Gluconate Dehydrogenase	HUMAN|HGNC=8891|UniProtKB=P52209	6-phosphogluconate dehydrogenase, decarboxylating	ISS	8978909	PubMed	PTHR11811:SF25	6-PHOSPHOGLUCONATE DEHYDROGENASE, DECARBOXYLATING
P05918	p38 MAPK pathway	P06029	p38beta	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P06587	Nicotine pharmacodynamics pathway	P06612	CHRNB3	CANLF|Ensembl=ENSCAFG00000005460|UniProtKB=F1PN73	Uncharacterized protein	ISS	15155845	PubMed	PTHR18945:SF75	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-3
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	HUMAN|HGNC=6693|UniProtKB=Q9NZR2	Low-density lipoprotein receptor-related protein 1B	IDA	11907044	PubMed	PTHR44025:SF7	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	MOUSE|MGI=MGI=1932410|UniProtKB=Q9EQ14	Interleukin-23 subunit alpha	IDA	11114383	PubMed	PTHR15947:SF0	INTERLEUKIN-23 SUBUNIT ALPHA
P00005	Angiogenesis	P00219	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00056	VEGF signaling pathway	P01408	Akt/PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00556	PLCgamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IGI	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02736	Coenzyme A biosynthesis	P02882	Pantothenate cysteine ligase	GLOVI|Gene=BAC89489|UniProtKB=Q7NKD0	Glr1548 protein	ISS			PTHR14359:SF6	PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DANRE|ZFIN=ZDB-GENE-020604-1|UniProtKB=Q6IQX1	Myosin, heavy polypeptide 2, fast muscle specific	IEP	89264452	PubMed	PTHR13140:SF676	MYOSIN, HEAVY POLYPEPTIDE 2, FAST MUSCLE SPECIFIC
P02723	Adenine and hypoxanthine salvage pathway	P02811	Adenosine deaminase	DROME|FlyBase=FBgn0037661|UniProtKB=Q9VHH7	Adenosine deaminase-like protein	ISS			PTHR11409:SF42	ADENOSINE DEAMINASE-LIKE PROTEIN
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00238	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	15531926	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04393	Ras Pathway	P04572	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	IDA	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	22533439	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEEL|WormBase=WBGene00004033|UniProtKB=P90980	Protein kinase C-like 2	ISS	2837282	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00029	Huntington disease	P00775	Rac	MACMU|Ensembl=ENSMMUG00000021075|UniProtKB=F7GY91	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00009	Axon guidance mediated by netrin	P00359	NFAT	HUMAN|HGNC=7776|UniProtKB=Q13469	Nuclear factor of activated T-cells, cytoplasmic 2	IDA	9462517	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00645	Rac	ENTHI|EnsemblGenome=EHI_197840|UniProtKB=C4M8K6	Rho family GTPase	ISS	4757952	gi	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	DICDI|dictyBase=DDB_G0273069|UniProtKB=P22887	Nucleoside diphosphate kinase, cytosolic	ISS			PTHR11349:SF64	NUCLEOSIDE DIPHOSPHATE KINASE HOMOLOG 5
P00036	Interleukin signaling pathway	P00983	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02749	Leucine biosynthesis	P03000	Branched chain amino acid aminotransferase	ARATH|TAIR=AT1G50110|UniProtKB=Q9LPM9	Branched-chain-amino-acid aminotransferase 6	ISS			PTHR42825:SF4	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 6-RELATED
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	NAS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	BOVIN|Ensembl=ENSBTAG00000004624|UniProtKB=E1B953	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00029	Huntington disease	P00808	Caspase 8	MACMU|Ensembl=ENSMMUG00000031296|UniProtKB=F7C587	Uncharacterized protein	ISS	8681376	PubMed	PTHR10454:SF162	CASPASE-8
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IPI	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	MACMU|Ensembl=ENSMMUG00000008111|UniProtKB=F7HIT3	C-C motif chemokine	ISS			PTHR12015:SF145	C-C MOTIF CHEMOKINE 4
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P02738	De novo purine biosynthesis	P02902	ADP reductase	SCHPO|PomBase=SPBC25D12.04|UniProtKB=P36603	Ribonucleoside-diphosphate reductase small chain	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00012	Cadherin signaling pathway	P00470	F-actin	BOVIN|Gene=ACTB|UniProtKB=P60712	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00045	Notch signaling pathway	P01114	Ntm	RAT|RGD=3187|UniProtKB=Q07008	Neurogenic locus notch homolog protein 1	IEP	12482957	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	ORNAN|Ensembl=ENSOANG00000010562|UniProtKB=F6TBG4	Uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=1764|UniProtKB=P33151	Cadherin-5	IDA	8120095	PubMed	PTHR24027:SF89	CADHERIN-5
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	PANTR|Ensembl=ENSPTRG00000004331|UniProtKB=H2Q4V3	Uncharacterized protein	ISS	8407942	PubMed	PTHR20859:SF43	INTERLEUKIN-10 RECEPTOR SUBUNIT ALPHA
P00029	Huntington disease	P00790	beta-Tubulin	HUMAN|HGNC=20776|UniProtKB=Q9BUF5	Tubulin beta-6 chain	TAS	12932731	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00019	Endothelin signaling pathway	P00587	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00010	B cell activation	P00391	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	ORNAN|Ensembl=ENSOANG00000000999|UniProtKB=F6WN02	Actin-related protein 2/3 complex subunit 5	ISS	12932731	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IGI	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02733	Carnitine metabolism	P02866	Carnitine dehydratase	MOUSE|MGI=MGI=1923221|UniProtKB=Q7TNE1	Succinate--hydroxymethylglutarate CoA-transferase	ISS			PTHR43949:SF6	SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00006	Apoptosis signaling pathway	P00269	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00923	Arf1	RAT|RGD=621270|UniProtKB=P84079	ADP-ribosylation factor 1	ISS	12932731	PubMed	PTHR11711:SF234	ADP-RIBOSYLATION FACTOR 1
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	BOVIN|Ensembl=ENSBTAG00000038716|UniProtKB=F1N727	Uncharacterized protein	ISS	10485843	PubMed	PTHR10005:SF15	SKI ONCOGENE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CANLF|Ensembl=ENSCAFG00000000517|UniProtKB=P51742	Tumor necrosis factor	IEP	11911478	PubMed	PTHR11471:SF23	TUMOR NECROSIS FACTOR
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04393	Ras Pathway	P04546	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02740	De novo pyrimidine ribonucleotides biosythesis	P02922	Orotate phosphoribosyltransferase	SYNY3|EnsemblGenome=BAA10077|UniProtKB=Q55574	Orotate phosphoribosyltransferase	ISS			PTHR19278:SF9	URIDINE 5'-MONOPHOSPHATE SYNTHASE
P05915	Opioid proenkephalin pathway	P05994	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00018	EGF receptor signaling pathway	P00539	14-3-3	DANRE|ZFIN=ZDB-GENE-050306-44|UniProtKB=Q5CZQ1	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	ANOGA|EnsemblGenome=AGAP004476|UniProtKB=Q7QA16	AGAP004476-PA	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00037	Ionotropic glutamate receptor pathway	P01026	KA	BOVIN|Ensembl=ENSBTAG00000034854|UniProtKB=F1N246	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05913	Enkephalin release	P05972	PKA	LEIMA|EnsemblGenome=LmjF.35.3960|UniProtKB=E9AFM1	Protein kinase A catalytic subunit isoform 2	ISS	14744463	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	DANRE|ZFIN=ZDB-GENE-010816-1|UniProtKB=Q9DGJ4	Odc1 protein	ISS			PTHR11482:SF42	ORNITHINE DECARBOXYLASE
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IGI	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	1691865	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00054	Toll receptor signaling pathway	P01375	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04649	Myc	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	TAS			PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00030	Hypoxia response via HIF activation	P00819	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	TAS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01167	Ets	MOUSE|MGI=MGI=2449712|UniProtKB=Q8QZW2	Protein FEV	ISS	15298723	PubMed	PTHR11849:SF203	PROTEIN FEV
P00047	PDGF signaling pathway	P01168	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	96009592	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	TAS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01161	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	12068308	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P05918	p38 MAPK pathway	P06031	p38alpha	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	RCA	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00013	Cell cycle	P00480	Proteasome	RAT|RGD=621109|UniProtKB=O88321	Antisecretory factor	ISS	11827521	PubMed	PTHR10223:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4
P02744	Fructose galactose metabolism	P02960	Galactokinase	MOUSE|MGI=MGI=95730|UniProtKB=Q9R0N0	Galactokinase	IDA	14741191	PubMed	PTHR10457:SF6	GALACTOKINASE
P00022	General transcription by RNA polymerase I	P00657	TBP	DANRE|ZFIN=ZDB-GENE-040520-2|UniProtKB=Q5U385	TATA box-binding protein-like protein 1	ISS	600075	OMIM	PTHR10126:SF13	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IGI	188830	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00644	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IGI	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	PYRAE|EnsemblGenome=PAE3442|UniProtKB=Q8ZT45	Glutamine synthetase	ISS			PTHR43785:SF1	TYPE-1 GLUTAMINE SYNTHETASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00006	Apoptosis signaling pathway	P00326	FAS ligand	MACMU|Gene=FASLG|UniProtKB=P63307	Tumor necrosis factor ligand superfamily member 6	ISS	7528780	PubMed	PTHR11471:SF33	TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 6
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	DANRE|ZFIN=ZDB-GENE-050522-181|UniProtKB=A5D6S6	Uncharacterized protein	ISS			PTHR23431:SF3	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT1G53510|UniProtKB=Q9C5C0	Mitogen-activated protein kinase 18	ISS	176948	OMIM	PTHR24055:SF200	MITOGEN-ACTIVATED PROTEIN KINASE 18-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DROME|FlyBase=FBgn0000047|UniProtKB=P83967	Actin, indirect flight muscle	IC	11889126	PubMed	PTHR11937:SF368	ACTIN, INDIRECT FLIGHT MUSCLE
P00010	B cell activation	P00385	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04395	Vasopressin synthesis	P04597	Signal Peptide	DANRE|ZFIN=ZDB-GENE-030407-1|UniProtKB=F1QC27	Uncharacterized protein	ISS	192340	OMIM	PTHR11681:SF14	SUBFAMILY NOT NAMED
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00623	FGF	PANTR|Ensembl=ENSPTRG00000008688|UniProtKB=H2QC40	Fibroblast growth factor	ISS			PTHR11486:SF67	FIBROBLAST GROWTH FACTOR 11
P00045	Notch signaling pathway	P01110	Presenilin	CANLF|Gene=PSEN1|UniProtKB=Q6RH31	Presenilin-1	ISS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00034	Integrin signalling pathway	P00922	Collagen	CANLF|Ensembl=ENSCAFG00000019985|UniProtKB=J9NYK4	Uncharacterized protein	ISS	10778855	PubMed	PTHR24023:SF42	COLLAGEN ALPHA-1 XI  CHAIN
P00023	General transcription regulation	P00658	TBP-associated factors	DANRE|ZFIN=ZDB-GENE-020419-18|UniProtKB=Q8JHG4	TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor	ISS			PTHR12228:SF0	TAF7 RNA POLYMERASE II, TATA BOX BINDING PROTEIN  TBP -ASSOCIATED FACTOR
P00034	Integrin signalling pathway	P00925	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	94313981	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	RAT|RGD=621544|UniProtKB=P12391	Neuronal acetylcholine receptor subunit beta-3	IC	15155845	PubMed	PTHR18945:SF75	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-3
P00049	Parkinson disease	P01213	Cyclin E	RAT|RGD=1307783|UniProtKB=D3ZQ41	Cyclin E2 (Predicted)	ISS	12628165	PubMed	PTHR10177:SF70	G1/S-SPECIFIC CYCLIN-E2
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	XENTR|Xenbase=XB-GENE-491618|UniProtKB=Q6P378	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00049	Parkinson disease	P01208	Hsp70	TRIVA|Gene=TVAG_161100|UniProtKB=A2E4W5	Cytoplasmic heat shock protein 70	IDA	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P02746	Heme biosynthesis	P02982	Protoheme IX farnesyl transferase	ECOLI|EcoGene=EG10182|UniProtKB=P0AEA5	Protoheme IX farnesyltransferase	ISS			PTHR43448:SF1	PROTOHEME IX FARNESYLTRANSFERASE
P00011	Blood coagulation	P00415	Plasmin	PANTR|Ensembl=ENSPTRG00000018774|UniProtKB=H2QU06	Plasminogen	ISS	130317	gi	PTHR24261:SF6	PLASMINOGEN
P02740	De novo pyrimidine ribonucleotides biosythesis	P02927	Dihydrooratate oxidase	METJA|EnsemblGenome=MJ_0654|UniProtKB=Q58070	Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit	ISS			PTHR43843:SF1	DIHYDROOROTATE DEHYDROGENASE  FUMARATE
P04393	Ras Pathway	P04565	MKK4/7	MACMU|Ensembl=ENSMMUG00000019842|UniProtKB=F7FU91	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00036	Interleukin signaling pathway	P00990	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00059	p53 pathway	P04626	GADD45	HUMAN|HGNC=4095|UniProtKB=P24522	Growth arrest and DNA damage-inducible protein GADD45 alpha	IGI	9827804	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	ARATH|TAIR=AT1G53750|UniProtKB=Q9SSB5	26S protease regulatory subunit 7 homolog A	ISS			PTHR23073:SF13	26S PROTEASE REGULATORY SUBUNIT 7
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	ISS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	ARATH|TAIR=AT3G61160|UniProtKB=O23145	Shaggy-related protein kinase beta	IDA			PTHR24057:SF19	SHAGGY-RELATED PROTEIN KINASE BETA-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00059	p53 pathway	P04633	P110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00020	FAS signaling pathway	P00600	PARP	ANOGA|EnsemblGenome=AGAP003230|UniProtKB=Q7QBC7	Poly [ADP-ribose] polymerase	ISS			PTHR10459:SF80	POLY  ADP-RIBOSE  POLYMERASE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00005	Angiogenesis	P00214	HIF-1	CANLF|Ensembl=ENSCAFG00000015718|UniProtKB=F1PZ54	Uncharacterized protein	ISS	14526383	PubMed	PTHR23043:SF7	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000012820|UniProtKB=F1MDL3	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00038	JAK/STAT signaling pathway	P01027	STAT	MOUSE|MGI=MGI=103038|UniProtKB=P42227	Signal transducer and activator of transcription 3	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04393	Ras Pathway	P04564	MAPKAP	PANTR|Ensembl=ENSPTRG00000001915|UniProtKB=H2Q104	Mitogen-activated protein kinase-activated protein kinase 2	ISS	10779545	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00019	Endothelin signaling pathway	P00589	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01177	P110ACT	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00022	General transcription by RNA polymerase I	P00651	TAF-IA	HUMAN|HGNC=17300|UniProtKB=Q7Z7C8	Transcription initiation factor TFIID subunit 8	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00030	Hypoxia response via HIF activation	P00823	PI3K	XENTR|Xenbase=XB-GENE-6067221|UniProtKB=F6Z0J4	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	MOUSE|MGI=MGI=103249|UniProtKB=P62204	Calmodulin	ISS	7514101	PubMed	PTHR23050:SF311	CALMODULIN
P00029	Huntington disease	P00805	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00011	Blood coagulation	P00411	PAI-1	PANTR|Ensembl=ENSPTRG00000019519|UniProtKB=H2QV47	Uncharacterized protein	ISS	18092159	gi	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04397	p53 pathway by glucose deprivation	P04640	p53	RAT|RGD=1307083|UniProtKB=D4AA88	Protein Tp73	ISS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04571	Tiam1	CANLF|Ensembl=ENSCAFG00000008853|UniProtKB=E2R0M7	Uncharacterized protein	ISS	11130063	PubMed	PTHR22826:SF88	T-LYMPHOMA INVASION AND METASTASIS-INDUCING PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	BOVIN|Ensembl=ENSBTAG00000043971|UniProtKB=E1BPT8	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00005	Angiogenesis	P00218	STAT1	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	15825084	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05931	EGR	DANRE|ZFIN=ZDB-GENE-980526-320|UniProtKB=P26632	Early growth response protein 1	ISS			PTHR44685:SF1	EARLY GROWTH RESPONSE PROTEIN 1
P00049	Parkinson disease	P01211	ERK	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	IDA	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	HUMAN|HGNC=7884|UniProtKB=Q99466	Neurogenic locus notch homolog protein 4	IDA	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	12657601	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MOUSE|MGI=MGI=95283|UniProtKB=P22387	Endothelin-1	ISS	15117818	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	HUMAN|HGNC=11769|UniProtKB=P10600	Transforming growth factor beta-3	TAS	9759503	PubMed	PTHR11848:SF34	TRANSFORMING GROWTH FACTOR BETA-3
P00035	Interferon-gamma signaling pathway	P00956	SOCS	BOVIN|Gene=SOCS5|UniProtKB=Q29RN6	Suppressor of cytokine signaling 5	ISS	15032587	PubMed	PTHR44282:SF3	SUPPRESSOR OF CYTOKINE SIGNALING 5
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IGI	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CAEBR|Gene=CBG16705|UniProtKB=A8XPN4	Protein CBR-LGC-11	ISS			PTHR18945:SF529	ACETYLCHOLINE RECEPTOR  51.1 KD   ACR-22 -RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00059	p53 pathway	P04629	PCAF	HUMAN|HGNC=8638|UniProtKB=Q92831	Histone acetyltransferase KAT2B	IDA	12724314	PubMed	PTHR22880:SF116	HISTONE ACETYLTRANSFERASE KAT2B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00008	Axon guidance mediated by Slit/Robo	P00352	DCC	MACMU|Ensembl=ENSMMUG00000013999|UniProtKB=F6RRI0	Uncharacterized protein	ISS	12798294	PubMed	PTHR44146:SF3	NETRIN RECEPTOR DCC
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MACMU|Ensembl=ENSMMUG00000020532|UniProtKB=F7D8E6	Ribosomal protein S6 kinase	ISS	15632195	PubMed	PTHR24351:SF98	RIBOSOMAL PROTEIN S6 KINASE ALPHA-6
P00046	Oxidative stress response	P01122	TRX	RAT|RGD=621157|UniProtKB=P11232	Thioredoxin	TAS	12115731	PubMed	PTHR10438:SF18	THIOREDOXIN
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	SCHMA|EnsemblGenome=Smp_192110|UniProtKB=G4VHK8	Putative tubulin beta chain	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00021	FGF signaling pathway	P00624	14-3-3	RAT|RGD=3978|UniProtKB=P68511	14-3-3 protein eta	ISS	14593000	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	RAT|RGD=71098|UniProtKB=P97633	Casein kinase I isoform alpha	IDA	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P02738	De novo purine biosynthesis	P02891	GDP kinase	CAEBR|Gene=CBG02247|UniProtKB=A8WS68	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00021	FGF signaling pathway	P00635	FRS2	CANLF|Ensembl=ENSCAFG00000032567|UniProtKB=J9NT83	Uncharacterized protein	ISS			PTHR21258:SF39	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 3
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	HUMAN|HGNC=7884|UniProtKB=Q99466	Neurogenic locus notch homolog protein 4	IDA	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	PANTR|Ensembl=ENSPTRG00000021182|UniProtKB=H2QXK2	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF61	TGF-BETA RECEPTOR TYPE-1
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	HUMAN|HGNC=11511|UniProtKB=Q9BQG1	Synaptotagmin-3	RCA			PTHR10024:SF176	SYNAPTOTAGMIN-3
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	MACMU|Ensembl=ENSMMUG00000004229|UniProtKB=F6SNN4	Uncharacterized protein	ISS			PTHR22778:SF16	DIHYDROFOLATE REDUCTASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	HUMAN|HGNC=5724|UniProtKB=Q06330	Recombining binding protein suppressor of hairless	NAS	12145413	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DANRE|ZFIN=ZDB-GENE-040426-2894|UniProtKB=Q7SXW6	Actin-related protein 2-A	ISS	11889126	PubMed	PTHR11937:SF149	ACTIN-RELATED PROTEIN 2-A-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=107735|UniProtKB=Q8C170	Unconventional myosin-IXa	ISS			PTHR13140:SF9	UNCONVENTIONAL MYOSIN-IXA
P00045	Notch signaling pathway	P01103	Next	CANLF|Ensembl=ENSCAFG00000010476|UniProtKB=F1PS94	Uncharacterized protein	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P05913	Enkephalin release	P05974	G-Protein (i)	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	BOVIN|Ensembl=ENSBTAG00000019986|UniProtKB=P35508	Casein kinase I isoform delta	ISS	10617630	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	TAS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00018	EGF receptor signaling pathway	P00556	PLCgamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00006	Apoptosis signaling pathway	P00271	Bax	DANRE|ZFIN=ZDB-GENE-000511-6|UniProtKB=I3ITC2	Uncharacterized protein	IDA			PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P00029	Huntington disease	P00807	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g234494|UniProtKB=A7RU31	Predicted protein	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00029	Huntington disease	P00807	Actin	SCLS1|Gene=SS1G_08733|UniProtKB=A7ETS6	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00059	p53 pathway	G04694	p110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02738	De novo purine biosynthesis	P02899	GMP synthase	FUSNN|EnsemblGenome=FN1444|UniProtKB=Q8RDR4	GMP synthase [glutamine-hydrolyzing]	ISS			PTHR11922:SF2	GMP SYNTHASE  GLUTAMINE-HYDROLYZING
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	ISS	9836510	gi	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01440	Cadherin	DANRE|ZFIN=ZDB-GENE-030910-3|UniProtKB=F1RD80	Uncharacterized protein	IDA	8120095	PubMed	PTHR44603:SF2	CADHERIN-17
P00010	B cell activation	P00379	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	10891487	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00009	Axon guidance mediated by netrin	P00366	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	SCHMA|EnsemblGenome=Smp_161920|UniProtKB=G4VSW5	Putative actin	ISS	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P02783	Tryptophan biosynthesis	P03207	Tryptophan synthase A	AQUAE|EnsemblGenome=aq_1548|UniProtKB=O67502	Tryptophan synthase alpha chain	ISS			PTHR43455:SF1	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	DROME|FlyBase=FBgn0010223|UniProtKB=Q05337	Guanine nucleotide-binding protein G(f) subunit alpha	ISS			PTHR10218:SF229	GUANINE NUCLEOTIDE-BINDING PROTEIN G F  SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	CANLF|Ensembl=ENSCAFG00000018832|UniProtKB=E2QYC2	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00008	Axon guidance mediated by Slit/Robo	P00351	Cxcr4	RAT|RGD=620465|UniProtKB=O08565	C-X-C chemokine receptor type 4	ISS	11943720	PubMed	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DANRE|ZFIN=ZDB-GENE-040625-35|UniProtKB=Q6IQL9	Novel actin protein	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=11333|UniProtKB=P31391	Somatostatin receptor type 4	IDA	12441358	PubMed	PTHR24229:SF52	SOMATOSTATIN RECEPTOR TYPE 4
P00049	Parkinson disease	P01234	GRK	MONDO|Ensembl=ENSMODG00000010516|UniProtKB=F7DR73	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04395	Vasopressin synthesis	P04590	Vasopressin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00638	PLCgamma	BOVIN|Ensembl=ENSBTAG00000002103|UniProtKB=F1N4C7	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000009871|UniProtKB=H2QE95	Uncharacterized protein	ISS	2106672	PubMed	PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00005	Angiogenesis	P00189	Fzd	MOUSE|MGI=MGI=1196625|UniProtKB=O70421	Frizzled-1	ISS	11212302	PubMed	PTHR11309:SF81	FRIZZLED-1
P00055	Transcription regulation by bZIP transcription factor	P01392	TFIIH complex	CANLF|Ensembl=ENSCAFG00000009171|UniProtKB=E2RCX0	Uncharacterized protein	ISS			PTHR12856:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 1
P00021	FGF signaling pathway	P00642	MEK1-2	CAEEL|WormBase=WBGene00003186|UniProtKB=Q10664	Dual specificity mitogen-activated protein kinase kinase mek-2	IGI	176872	OMIM	PTHR24361:SF629	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00053	T cell activation	P01332	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02746	Heme biosynthesis	P02972	Ferrochelatase	DANRE|ZFIN=ZDB-GENE-000928-1|UniProtKB=F1R362	Ferrochelatase	ISS			PTHR11108:SF1	FERROCHELATASE, MITOCHONDRIAL
P00010	B cell activation	P00379	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00001	Adrenaline and noradrenaline biosynthesis	P00071	VAT1	MOUSE|MGI=MGI=106677|UniProtKB=Q8BRU6	Synaptic vesicular amine transporter	ISS			PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Ensembl=ENSBTAG00000018989|UniProtKB=A5D7D8	GRM3 protein	ISS	9407094	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00048	PI3 kinase pathway	P01177	P110ACT	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	188830	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04393	Ras Pathway	P04558	p38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	IDA	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	CANLF|Ensembl=ENSCAFG00000019633|UniProtKB=F1PDC7	Uncharacterized protein	ISS	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P06587	Nicotine pharmacodynamics pathway	P06604	SLC18A2	HUMAN|HGNC=10935|UniProtKB=Q05940	Synaptic vesicular amine transporter	TAS	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00019	Endothelin signaling pathway	P00589	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	NAS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01202	p85	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00034	Integrin signalling pathway	P00923	Arf1	PANTR|Ensembl=ENSPTRG00000002066|UniProtKB=G2HIU2	ADP-ribosylation factor 1	ISS	12932731	PubMed	PTHR11711:SF234	ADP-RIBOSYLATION FACTOR 1
P00021	FGF signaling pathway	P00632	Akt	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	ISS	12655147	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04653	cdk2	MACMU|Ensembl=ENSMMUG00000018817|UniProtKB=F6ZHC1	Uncharacterized protein	ISS	15660127	PubMed	PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P00045	Notch signaling pathway	P01113	Pen-2	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	ISS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00758	Phosducin	CANLF|Ensembl=ENSCAFG00000013751|UniProtKB=O77560	Phosducin	ISS	10360181	PubMed	PTHR21148:SF17	PHOSDUCIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00759	PDEalphabeta	ORNAN|Ensembl=ENSOANG00000009367|UniProtKB=F7G5L8	Phosphodiesterase	ISS	P27664	SPACC	PTHR11347:SF115	ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	MOUSE|MGI=MGI=88398|UniProtKB=Q9ERZ3	Muscarinic acetylcholine receptor M3	ISS	12915051	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04393	Ras Pathway	P04557	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04452	proopiomelanocortin	BOVIN|Ensembl=ENSBTAG00000007897|UniProtKB=P01190	Pro-opiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CAEEL|WormBase=WBGene00004039|UniProtKB=Q21754	Phosphoinositide phospholipase C	TAS			PTHR10336:SF147	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-2
P00029	Huntington disease	G01530	HTT	HUMAN|HGNC=4851|UniProtKB=P42858	Huntingtin	IDA	7620118	PubMed	PTHR10170:SF10	HUNTINGTIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IC	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00059	p53 pathway	P04612	HDAC1	XENTR|Xenbase=XB-GENE-479583|UniProtKB=F6ULG8	Histone deacetylase	ISS	12665570	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	IC	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05730	Endogenous cannabinoid signaling	P05746	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00006	Apoptosis signaling pathway	P00272	ASK1	BOVIN|Ensembl=ENSBTAG00000009065|UniProtKB=F1MXH6	Uncharacterized protein	ISS	12968034	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00056	VEGF signaling pathway	P01413	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	129387	gi	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00053	T cell activation	P01300	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02774	Salvage pyrimidine deoxyribonucleotides	P03146	Deoxyuridine kinase	CAEBR|Gene=CBG04406|UniProtKB=A8WXG7	Thymidine kinase	ISS			PTHR11441:SF0	THYMIDINE KINASE, CYTOSOLIC
P00048	PI3 kinase pathway	P01190	PDK1 ACT	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00562	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00005	Angiogenesis	P00203	Erk	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DICDI|dictyBase=DDB_G0283907|UniProtKB=P34099	cAMP-dependent protein kinase catalytic subunit	IC	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	TAS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00001	Adrenaline and noradrenaline biosynthesis	P00065	DAT	RAT|RGD=3715|UniProtKB=P23977	Sodium-dependent dopamine transporter	ISS	92107910	PubMed	PTHR11616:SF38	SODIUM-DEPENDENT DOPAMINE TRANSPORTER
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=1310903|UniProtKB=D4A978	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF33	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	RCA	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05731	GABA-B receptor II signaling	P05754	Ggamma	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00545	JNK1-3	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05916	Opioid prodynorphin pathway	P06002	G-protein	ANOGA|EnsemblGenome=AGAP005773|UniProtKB=A0NEH6	AGAP005773-PA	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00520	Rho GAPs	MACMU|Ensembl=ENSMMUG00000031000|UniProtKB=F6Y6A5	Uncharacterized protein	ISS			PTHR23176:SF3	PROTEIN PRR5-ARHGAP8-RELATED
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00048	PI3 kinase pathway	P01192	p110	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	ANOGA|EnsemblGenome=AGAP004661|UniProtKB=Q7PGA9	AGAP004661-PA	IEP	12356903	PubMed	PTHR24326:SF144	HOMEOTIC PROTEIN ULTRABITHORAX
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00206	Wnt	CHICK|Ensembl=ENSGALG00000005410|UniProtKB=Q9YGX6	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00981	SOS	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04393	Ras Pathway	P04544	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	10521483	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00006	Apoptosis signaling pathway	P00305	Caspase 3	MOUSE|MGI=MGI=107739|UniProtKB=P70677	Caspase-3	ISS	9323209	PubMed	PTHR10454:SF198	CASPASE-3
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MACMU|Ensembl=ENSMMUG00000018445|UniProtKB=F7HEW6	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P04398	p53 pathway feedback loops 2	P04651	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IDA	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P06664	Gonadotropin-releasing hormone receptor pathway	P06773	gnai/o	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00574	Big ET1-4	RAT|RGD=2532|UniProtKB=P22388	Endothelin-1	ISS	15117818	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P00036	Interleukin signaling pathway	P00965	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	RAT|RGD=619731|UniProtKB=Q9QYP1	Low-density lipoprotein receptor-related protein 4	ISS	11907044	PubMed	PTHR44017:SF4	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MONDO|Ensembl=ENSMODG00000009514|UniProtKB=F7EVK3	Uncharacterized protein	ISS	11390664	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	TAKRU|Ensembl=ENSTRUG00000016101|UniProtKB=H2UW32	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Ensembl=ENSPTRG00000018449|UniProtKB=H2QTG5	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00629	PP2A	RAT|RGD=631441|UniProtKB=P36877	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform	IGI	12716901	PubMed	PTHR11871:SF1	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B BETA ISOFORM
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	DROME|FlyBase=FBgn0029823|UniProtKB=Q9W457	Serine hydroxymethyltransferase	ISS			PTHR11680:SF21	SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04553	PAK	XENTR|Xenbase=XB-GENE-961764|UniProtKB=F6W3Y0	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	MOUSE|MGI=MGI=106677|UniProtKB=Q8BRU6	Synaptic vesicular amine transporter	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05918	p38 MAPK pathway	P06013	ELK	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	RCA	14670631	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00030	Hypoxia response via HIF activation	P00818	HIF-1alpha	CANLF|Ensembl=ENSCAFG00000015718|UniProtKB=F1PZ54	Uncharacterized protein	ISS	9606183	PubMed	PTHR23043:SF7	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=1339713|UniProtKB=Q5SX39	Myosin-4	IC	10938134	PubMed	PTHR13140:SF657	MYOSIN-4
P00038	JAK/STAT signaling pathway	P01027	STAT	CHICK|Ensembl=ENSGALG00000003267|UniProtKB=Q6DV79	Signal transducer and activator of transcription 3	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	CHICK|Gene_ORFName=RCJMB04_6o17|UniProtKB=Q5ZLA6	Unconventional myosin-Ic	IC			PTHR13140:SF255	UNCONVENTIONAL MYOSIN-IC
P00012	Cadherin signaling pathway	P00470	F-actin	MOUSE|MGI=MGI=1913963|UniProtKB=P61161	Actin-related protein 2	ISS	10974003	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P02772	Pyruvate metabolism	P03132	Pyruvate Kinase	MACMU|Ensembl=ENSMMUG00000023143|UniProtKB=F7FI39	Pyruvate kinase	RCA			PTHR11817:SF31	PYRUVATE KINASE PKLR
P02738	De novo purine biosynthesis	P02891	GDP kinase	SCHPO|PomBase=SPAC806.07|UniProtKB=P49740	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00010	B cell activation	P00373	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IGI	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00049	Parkinson disease	P01211	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	BOVIN|Ensembl=ENSBTAG00000008216|UniProtKB=E1BI58	Uncharacterized protein	ISS			PTHR23409:SF20	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P02748	Isoleucine biosynthesis	P02994	Branched chain amino acid aminotransferase	BACSU|EnsemblGenome=BSU02390|UniProtKB=O31461	Branched-chain-amino-acid transaminase 1	ISS			PTHR11825:SF44	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P00053	T cell activation	P01332	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	88248054	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00006	Apoptosis signaling pathway	P00321	HSP70	ORYSJ|EnsemblGenome=OS03G0710500|UniProtKB=Q53RJ5	DnaK protein	ISS	12150907	PubMed	PTHR19375:SF215	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 37B-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06850	PKCs(3)	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00024	Glycolysis	P00679	Aldolase	RAT|RGD=2089|UniProtKB=P05065	Fructose-bisphosphate aldolase A	ISS	6086339	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	IDA	14744463	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MACMU|Ensembl=ENSMMUG00000018877|UniProtKB=F6WYU6	Regulator of G-protein signaling 19	ISS	8756726	PubMed	PTHR10845:SF145	REGULATOR OF G-PROTEIN SIGNALING 19
P00029	Huntington disease	P00780	Microtubule	XENTR|Xenbase=XB-GENE-491459|UniProtKB=L7N3Q3	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00563	Gab	MACMU|Ensembl=ENSMMUG00000017477|UniProtKB=F6VIK2	Uncharacterized protein	ISS	15356145	PubMed	PTHR12156:SF4	GRB2-ASSOCIATED-BINDING PROTEIN 2
P00018	EGF receptor signaling pathway	P00557	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IGI	96009592	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MACMU|Ensembl=ENSMMUG00000006621|UniProtKB=F7HKD3	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00005	Angiogenesis	P00200	Dsh	RAT|RGD=1308834|UniProtKB=D4ADV8	Protein Dvl3	ISS	10409711	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P02752	Mannose metabolism	P03015	GDP-Mannose 4,6-dehydratase	ECOLI|EcoGene=EG11787|UniProtKB=P0AC88	GDP-mannose 4,6-dehydratase	IEA	11677608	PubMed	PTHR43715:SF1	GDP-MANNOSE 4,6 DEHYDRATASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	TAS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06779	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	RCA	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00648	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00011	Blood coagulation	P00448	vWF	HUMAN|HGNC=12726|UniProtKB=P04275	von Willebrand factor	ISS	11583304	PubMed	PTHR11339:SF361	VON WILLEBRAND FACTOR-RELATED
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	HUMAN|HGNC=10935|UniProtKB=Q05940	Synaptic vesicular amine transporter	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	MONDO|Ensembl=ENSMODG00000017905|UniProtKB=F7FG65	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Gene=HTR1A|UniProtKB=Q9N298	5-hydroxytryptamine receptor 1A	IDA	12181435	PubMed	PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P00053	T cell activation	P01332	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06004	Mu or Delta receptor	PANTR|Ensembl=ENSPTRG00000000440|UniProtKB=H2PYH8	Uncharacterized protein	ISS	11259487	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	DROME|FlyBase=FBgn0032859|UniProtKB=Q9VIM5	Actin-related protein 2/3 complex subunit 2	ISS	17943202	gi	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	DICDI|dictyBase=DDB_G0276885|UniProtKB=Q02720	Casein kinase II subunit alpha	IDA	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00049	Parkinson disease	P01229	Pael-R	MACMU|Ensembl=ENSMMUG00000010664|UniProtKB=F7B4P4	Putative G-protein coupled receptor 37	ISS	12150907	PubMed	PTHR24243:SF32	PROSAPOSIN RECEPTOR GPR37
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MONDO|Ensembl=ENSMODG00000001384|UniProtKB=F7GL73	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00005	Angiogenesis	P00195	APC	RAT|RGD=1308256|UniProtKB=A0A0G2JZW4	Protein Apc2	ISS	10491393	PubMed	PTHR12607:SF3	ADENOMATOUS POLYPOSIS COLI PROTEIN 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	RCA	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00021	FGF signaling pathway	P00627	ERK1-2	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	92020947	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	RAT|RGD=621516|UniProtKB=G3V6P8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00015	Circadian clock system	G01501	cry	RAT|RGD=735083|UniProtKB=Q32Q86	Cryptochrome-1	ISS	10217146	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00018	EGF receptor signaling pathway	P00562	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	12374793	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00059	p53 pathway	G01579	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00020	FAS signaling pathway	P00615	JNK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IDA	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P00999	PSD95	BOVIN|Ensembl=ENSBTAG00000030180|UniProtKB=G3X7P4	Uncharacterized protein	ISS	20020275	PubMed	PTHR24135:SF4	SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	PANTR|Ensembl=ENSPTRG00000010386|UniProtKB=H2QF61	Tyrosine-protein kinase receptor	ISS	11182407	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00006	Apoptosis signaling pathway	P00260	AKT	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P05730	Endogenous cannabinoid signaling	P05746	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00047	PDGF signaling pathway	P01143	ERK	DICDI|dictyBase=DDB_G0283903|UniProtKB=Q54QB1	Extracellular signal-regulated kinase 2	ISS	10514528	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00017	DNA replication	P00538	RNase H	HALSA|EnsemblGenome=VNG_1984G|UniProtKB=Q9HNR3	Ribonuclease HII	ISS	20504483	PubMed	PTHR10954:SF7	RIBONUCLEASE H2 SUBUNIT A
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00005	Angiogenesis	P00217	STAT3	RAT|RGD=3772|UniProtKB=P52631	Signal transducer and activator of transcription 3	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000022886|UniProtKB=E1BE29	Uncharacterized protein	ISS	8930069	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01286	TGFbeta	CHICK|Ensembl=ENSGALG00000001786|UniProtKB=F1NGR7	Uncharacterized protein	TAS	9759503	PubMed	PTHR11848:SF44	GROWTH/DIFFERENTIATION FACTOR 5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	HUMAN|HGNC=4588|UniProtKB=O15399	Glutamate receptor ionotropic, NMDA 2D	IC	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2D.html	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P05731	GABA-B receptor II signaling	P05752	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00005	Angiogenesis	P00219	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000038881|UniProtKB=H2RI77	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000006289|UniProtKB=H2Q875	Uncharacterized protein	ISS	12441358	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P02729	Ascorbate degradation	P02849	L-xylulose kinase	ECOLI|EcoGene=EG11075|UniProtKB=P09099	Xylulose kinase	ISS			PTHR43095:SF6	XYLULOSE KINASE
P00060	Ubiquitin proteasome pathway	P01494	19S proteasome	DANRE|ZFIN=ZDB-GENE-030131-5083|UniProtKB=B0R1D0	Novel protein (Zgc:63709)	ISS			PTHR23073:SF8	26S PROTEASE REGULATORY SUBUNIT 6B
P00025	Hedgehog signaling pathway	P00692	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00034	Integrin signalling pathway	P00931	Integrin beta	CANLF|Ensembl=ENSCAFG00000013735|UniProtKB=F1PPG5	Integrin beta	IDA	484963	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	HUMAN|HGNC=667|UniProtKB=P61586	Transforming protein RhoA	ISS	12039949	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00057	Wnt signaling pathway	P01466	Diversin	MACMU|Ensembl=ENSMMUG00000003462|UniProtKB=F7EBN2	Uncharacterized protein	ISS	12183362	PubMed	PTHR24203:SF7	ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 6
P05913	Enkephalin release	P05977	G-Protein (s)	MONDO|Ensembl=ENSMODG00000021434|UniProtKB=F7CB49	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P06664	Gonadotropin-releasing hormone receptor pathway	P06791	Isl-1	MOUSE|MGI=MGI=101791|UniProtKB=P61372	Insulin gene enhancer protein ISL-1	RCA			PTHR24204:SF3	INSULIN GENE ENHANCER PROTEIN ISL-1
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	MACMU|Ensembl=ENSMMUG00000022513|UniProtKB=F6YNZ0	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00013	Cell cycle	P00480	Proteasome	BOVIN|Ensembl=ENSBTAG00000002423|UniProtKB=Q2KJ25	26S proteasome non-ATPase regulatory subunit 12	ISS	12477932	PubMed	PTHR10855:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12
P00046	Oxidative stress response	P01132	c-jun	XENTR|Xenbase=XB-GENE-482228|UniProtKB=F6RYL1	Uncharacterized protein	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00029	Huntington disease	P00780	Microtubule	CANLF|Ensembl=ENSCAFG00000000443|UniProtKB=E2QSF4	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00052	TGF-beta signaling pathway	P01277	TGFbetareceptor II	RAT|RGD=70964|UniProtKB=Q62893	Anti-Muellerian hormone type-2 receptor	TAS	9395284	PubMed	PTHR23255:SF49	ANTI-MUELLERIAN HORMONE TYPE-2 RECEPTOR
P04393	Ras Pathway	P04561	SRF	PANTR|Ensembl=ENSPTRG00000018189|UniProtKB=H2QT21	Uncharacterized protein	ISS	8660892	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00034	Integrin signalling pathway	P00907	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00006	Apoptosis signaling pathway	P00305	Caspase 3	RAT|RGD=2275|UniProtKB=P55213	Caspase-3	ISS	9323209	PubMed	PTHR10454:SF198	CASPASE-3
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IGI	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00030	Hypoxia response via HIF activation	P00819	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00624	14-3-3	ORYSJ|EnsemblGenome=OS08G0480800|UniProtKB=Q84J55	14-3-3-like protein GF14-A	ISS	20493542	PubMed	PTHR18860:SF26	14-3-3 FAMILY PROTEIN-RELATED
P00034	Integrin signalling pathway	P00925	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	HUMAN|HGNC=3023|UniProtKB=P14416	D(2) dopamine receptor	ISS	1319557	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P04393	Ras Pathway	P04559	Rac	ORYSJ|EnsemblGenome=OS02G0120800|UniProtKB=Q6ZHA3	Rac-like GTP-binding protein 6	ISS	12932731	PubMed	PTHR24072:SF261	SUBFAMILY NOT NAMED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00019	Endothelin signaling pathway	P00566	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	DANRE|ZFIN=ZDB-GENE-030131-8013|UniProtKB=F1QBT6	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	11554554	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P02747	Histidine biosynthesis	P02984	Imidazol glycerol phosphate dehydratase	THEMA|EnsemblGenome=TM_1039|UniProtKB=Q9X0C9	Imidazoleglycerol-phosphate dehydratase	ISS			PTHR23133:SF2	IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE
P00019	Endothelin signaling pathway	P00572	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04393	Ras Pathway	P04569	Cdc42	TAKRU|Ensembl=ENSTRUG00000008289|UniProtKB=H2T7U8	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF129	CDC42L PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00148	Erb-B4 N-terminal fragment	ORNAN|Ensembl=ENSOANG00000007021|UniProtKB=F7GAV2	Receptor protein-tyrosine kinase	ISS	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00012	Cadherin signaling pathway	P00470	F-actin	DICDI|dictyBase=DDB_G0275023|UniProtKB=Q553U6	Putative actin-22	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00047	PDGF signaling pathway	P01162	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00778	NMDA receptor	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	HUMAN|HGNC=6264|UniProtKB=P48549	G protein-activated inward rectifier potassium channel 1	ISS	12374786	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000023202|UniProtKB=F7EU36	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04393	Ras Pathway	P04567	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00552	Ras	ANOGA|EnsemblGenome=AGAP002219|UniProtKB=Q7QK91	AGAP002219-PA	ISS	10684567	PubMed	PTHR24070:SF385	GTPASE HRAS
P02738	De novo purine biosynthesis	P02899	GMP synthase	METJA|EnsemblGenome=MJ_1131|UniProtKB=Q58531	GMP synthase [glutamine-hydrolyzing] subunit B	ISS			PTHR11922:SF2	GMP SYNTHASE  GLUTAMINE-HYDROLYZING
P00019	Endothelin signaling pathway	P00589	Akt	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	IGI	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	CAEBR|Gene=CBG_05938|UniProtKB=H8WGV2	Protein CBR-ITR-1, isoform a	ISS	11007872	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00049	Parkinson disease	P01219	SAPK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00018	EGF receptor signaling pathway	P00547	PP2A	MOUSE|MGI=MGI=1349475|UniProtKB=Q60996	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	ISS	10092233	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00062	TH	MOUSE|MGI=MGI=98735|UniProtKB=P24529	Tyrosine 3-monooxygenase	ISS	12480184	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	PANTR|Ensembl=ENSPTRG00000001787|UniProtKB=H2Q0T0	Phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	ISS	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00029	Huntington disease	P00797	p53	HUMAN|HGNC=13759|UniProtKB=Q7L576	Cytoplasmic FMR1-interacting protein 1	ISS			PTHR12195:SF2	CYTOPLASMIC FMR1-INTERACTING PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	HUMAN|HGNC=6695|UniProtKB=O75074	Low-density lipoprotein receptor-related protein 3	IDA	11907044	PubMed	PTHR44062:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 3
P00019	Endothelin signaling pathway	P00587	Raf-1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05974	G-Protein (i)	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00291	MEKK1	PANTR|Ensembl=ENSPTRG00000016891|UniProtKB=H2R5K3	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_127490|UniProtKB=C3XYC5	Putative uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	AQUAE|EnsemblGenome=aq_094|UniProtKB=O66503	Ribonucleoside-diphosphate reductase subunit alpha	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	DROME|FlyBase=FBgn0003416|UniProtKB=Q9VXH3	Phosphoinositide phospholipase C	ISS			PTHR10336:SF91	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00056	VEGF signaling pathway	P01419	Ets	PANTR|Ensembl=ENSPTRG00000004466|UniProtKB=H2RCM3	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	RCA	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00546	GAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	8270251	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00004	Alzheimer disease-presenilin pathway	P00111	C99	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00010	B cell activation	P00383	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IDA	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00012	Cadherin signaling pathway	P00475	Frizzled	CANLF|Ensembl=ENSCAFG00000008293|UniProtKB=E2R9M9	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF22	FRIZZLED-3
P02759	Pyridoxal-5-phosphate biosynthesis	P03058	Phosphohydroxythreonine aminotransferase	METAC|EnsemblGenome=MA_2304|UniProtKB=Q8TNI1	Phosphoserine aminotransferase	ISS			PTHR21152:SF24	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00046	Oxidative stress response	P01126	ATF2	MONDO|Ensembl=ENSMODG00000009514|UniProtKB=F7EVK3	Uncharacterized protein	ISS	10664585	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00034	Integrin signalling pathway	P00938	Cdc42	ANOGA|EnsemblGenome=AGAP002440|UniProtKB=Q17031	Cdc42 homolog	ISS	12932731	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00029	Huntington disease	P00786	ARF	BOVIN|Ensembl=ENSBTAG00000045980|UniProtKB=G3N3N1	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00049	Parkinson disease	P01211	ERK	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	IDA	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00036	Interleukin signaling pathway	P00983	Raf	HUMAN|HGNC=646|UniProtKB=P10398	Serine/threonine-protein kinase A-Raf	IC	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CHICK|Ensembl=ENSGALG00000007794|UniProtKB=A9YZQ5	Dopamine receptor 2 protein transcript variant 1	ISS	2137198	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	IDA	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02781	Threonine biosynthesis	P03190	Threonine synthase	LEIMA|EnsemblGenome=LmjF.14.0350|UniProtKB=Q4QFV0	Putative threonine synthase	ISS			PTHR43515:SF1	THREONINE SYNTHASE-LIKE 1
P02770	Pyridoxal phosphate salvage pathway	P03122	Pyridoxamine kinase	MACMU|Ensembl=ENSMMUG00000012300|UniProtKB=F7DLS4	Uncharacterized protein	ISS	9099727	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	MACMU|Ensembl=ENSMMUG00000014597|UniProtKB=F6VAQ6	Glycogen synthase kinase-3 alpha	ISS	183955	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	IDA	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02730	Asparagine and aspartate biosynthesis	P02853	Asparagine synthetase	MACMU|Ensembl=ENSMMUG00000019157|UniProtKB=F6SSI3	Uncharacterized protein	ISS			PTHR11772:SF23	ASPARAGINE SYNTHETASE  GLUTAMINE-HYDROLYZING
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	PANTR|Ensembl=ENSPTRG00000006510|UniProtKB=H2Q8K1	Presenilin	ISS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00056	VEGF signaling pathway	P01425	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	11591316	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	HUMAN|HGNC=18854|UniProtKB=Q8TEY5	Cyclic AMP-responsive element-binding protein 3-like protein 4	RCA			PTHR22952:SF105	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	BOVIN|Gene=MYH7|UniProtKB=Q9BE39	Myosin-7	ISS	10938134	PubMed	PTHR13140:SF344	MYOSIN-7
P00005	Angiogenesis	P00193	SOS-1	BOVIN|Ensembl=ENSBTAG00000011643|UniProtKB=F1N7C3	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00011	Blood coagulation	P00429	PN2	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01465	Ggamma	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	PANTR|Ensembl=ENSPTRG00000011718|UniProtKB=H2QHJ5	Adenylate cyclase 3	ISS	12623444	PubMed	PTHR11920:SF291	ADENYLATE CYCLASE TYPE 3
P04397	p53 pathway by glucose deprivation	P04644	TSC2	CANLF|Ensembl=ENSCAFG00000019438|UniProtKB=F1Q054	Uncharacterized protein	ISS	15249583	PubMed	PTHR10063:SF0	TUBERIN
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CHICK|Gene=CHRM3|UniProtKB=P49578	Muscarinic acetylcholine receptor M3	IDA	10069496	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01332	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PHYPA|Gene=PHYPADRAFT_107830|UniProtKB=A9TBG2	Actin 7	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	7925653	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04542	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00811	Arp2/3 complex	MOUSE|MGI=MGI=1915021|UniProtKB=Q9CPW4	Actin-related protein 2/3 complex subunit 5	ISS	12932731	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P05731	GABA-B receptor II signaling	P05752	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	CHICK|Ensembl=ENSGALG00000003820|UniProtKB=E1C8Y3	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00059	p53 pathway	P04630	PP2A	MACMU|Ensembl=ENSMMUG00000013047|UniProtKB=F7H808	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	CANLF|Ensembl=ENSCAFG00000012925|UniProtKB=E2REQ8	Uncharacterized protein	ISS	10487978	PubMed	PTHR10749:SF5	PHOSPHORYLASE B KINASE REGULATORY SUBUNIT ALPHA, LIVER ISOFORM
P02752	Mannose metabolism	P03015	GDP-Mannose 4,6-dehydratase	MOUSE|MGI=MGI=1891112|UniProtKB=Q8K0C9	GDP-mannose 4,6 dehydratase	ISS	9603974	PubMed	PTHR43715:SF1	GDP-MANNOSE 4,6 DEHYDRATASE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	SCHPO|PomBase=SPAC6G9.11|UniProtKB=Q92356	Synaptobrevin homolog 1	IC			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P05918	p38 MAPK pathway	P06029	p38beta	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00053	T cell activation	P01332	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	MONDO|Ensembl=ENSMODG00000009988|UniProtKB=F6UST7	Uncharacterized protein	ISS	12374786	PubMed	PTHR11767:SF17	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 3
P00047	PDGF signaling pathway	P01160	IP3 receptor	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00021	FGF signaling pathway	P00628	JNK1-3	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	ISS			PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00051	TCA cycle	P01267	Citrate Synthase	DANRE|ZFIN=ZDB-GENE-030131-1058|UniProtKB=Q7ZVY5	Citrate synthase, mitochondrial	ISS	12477932	PubMed	PTHR11739:SF8	CITRATE SYNTHASE, MITOCHONDRIAL
P00049	Parkinson disease	P01219	SAPK	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	8925912	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00010	B cell activation	P00402	Jnk	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	DROME|FlyBase=FBgn0003416|UniProtKB=Q9VXH3	Phosphoinositide phospholipase C	ISS			PTHR10336:SF91	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04393	Ras Pathway	P04567	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	PANTR|Ensembl=ENSPTRG00000001792|UniProtKB=H2Q0T4	Regulator of G-protein signaling 2, 24kDa	ISS	8756726	PubMed	PTHR10845:SF43	REGULATOR OF G-PROTEIN SIGNALING 2
P00005	Angiogenesis	P00223	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000014227|UniProtKB=P56490	Muscarinic acetylcholine receptor M5	IDA			PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P02759	Pyridoxal-5-phosphate biosynthesis	P03058	Phosphohydroxythreonine aminotransferase	ECOLI|EcoGene=EG10946|UniProtKB=P23721	Phosphoserine aminotransferase	ISS	11206551	PubMed	PTHR43247:SF2	PHOSPHOSERINE AMINOTRANSFERASE
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00797	p53	MACMU|Ensembl=ENSMMUG00000010997|UniProtKB=F7GQY1	Uncharacterized protein	ISS			PTHR12195:SF1	CYTOPLASMIC FMR1-INTERACTING PROTEIN 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	ORNAN|Ensembl=ENSOANG00000013961|UniProtKB=F6VPY1	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P05913	Enkephalin release	P05977	G-Protein (s)	ANOGA|EnsemblGenome=AGAP001506|UniProtKB=Q7PXP3	AGAP001506-PA	IC			PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CANLF|Ensembl=ENSCAFG00000015708|UniProtKB=F2Z4N0	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00047	PDGF signaling pathway	P01153	GSK3	HUMAN|HGNC=14906|UniProtKB=Q8N4C6	Ninein	ISS			PTHR18905:SF11	NINEIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04455	beta-endorphin	PANTR|Ensembl=ENSPTRG00000011721|UniProtKB=H2R8Y3	Uncharacterized protein	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=62388|UniProtKB=P35365	5-hydroxytryptamine receptor 5B	IDA	12441358	PubMed	PTHR24247:SF14	5-HYDROXYTRYPTAMINE RECEPTOR 5B
P00017	DNA replication	P00536	DNA Topisomerase	SCHPO|PomBase=SPBC1703.14c|UniProtKB=P07799	DNA topoisomerase 1	ISS			PTHR10290:SF3	DNA TOPOISOMERASE 1
P00021	FGF signaling pathway	P00627	ERK1-2	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P02728	Arginine biosynthesis	P02846	Ornithine carbamoyl transferase	ARATH|TAIR=AT1G75330|UniProtKB=O50039	Ornithine carbamoyltransferase, chloroplastic	ISS			PTHR11405:SF1	ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DROME|FlyBase=FBgn0261854|UniProtKB=A1Z9X0	Atypical protein kinase C	IC	3755548	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00010	B cell activation	P00391	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	ORNAN|Ensembl=ENSOANG00000015652|UniProtKB=F7FY70	Uncharacterized protein	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PHYPA|Gene=PHYPADRAFT_121199|UniProtKB=A9RY37	Predicted protein	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00017	DNA replication	P00527	Histones	PUCGT|EnsemblGenome=PGTG_00393|UniProtKB=E3JR96	Histone H3	ISS	12413958	PubMed	PTHR11426:SF47	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IC	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04393	Ras Pathway	P04541	p90RSK	MACMU|Ensembl=ENSMMUG00000002134|UniProtKB=F6UNV6	Ribosomal protein S6 kinase	ISS	10558991	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00036	Interleukin signaling pathway	P00973	PKB	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01465	Ggamma	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IC	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00011	Blood coagulation	P00425	ZPI	MOUSE|MGI=MGI=2667725|UniProtKB=Q8R121	Protein Z-dependent protease inhibitor	ISS	20858181	gi	PTHR11461:SF191	PROTEIN Z-DEPENDENT PROTEASE INHIBITOR
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04558	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IDA	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00036	Interleukin signaling pathway	P00981	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	20010089	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P06959	CCKR signaling map	P07162	PDPK1	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	RCA	12829245	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	MOUSE|MGI=MGI=1339713|UniProtKB=Q5SX39	Myosin-4	ISS	10938134	PubMed	PTHR13140:SF657	MYOSIN-4
P00053	T cell activation	P01312	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00029	Huntington disease	P00785	Cytochrome c	TRYB2|Gene=Tb927.8.1890|UniProtKB=D6XKS6	Cytochrome c1, heme protein, mitochondrial	ISS	9027315	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00021	FGF signaling pathway	P00640	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00053	T cell activation	P01336	Jnk	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04393	Ras Pathway	P04546	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	DROME|FlyBase=FBgn0262738|UniProtKB=P13217	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF31	SUBFAMILY NOT NAMED
P00009	Axon guidance mediated by netrin	P00363	PI3K	XENTR|Xenbase=XB-GENE-6067221|UniProtKB=F6Z0J4	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	MOUSE|MGI=MGI=99685|UniProtKB=E9Q401	Ryanodine receptor 2	ISS	15226293	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	ISS	11889139	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	ORNAN|Ensembl=ENSOANG00000011750|UniProtKB=F6TWB9	Nucleoside diphosphate kinase	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00045	Notch signaling pathway	P01104	Serrate	HUMAN|HGNC=6188|UniProtKB=P78504	Protein jagged-1	IGI	1286675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PRIPA|Gene=PPA19914|UniProtKB=H3FCG4	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF359	SUBFAMILY NOT NAMED
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00019	Endothelin signaling pathway	P00580	ET-RA/B	HUMAN|HGNC=3180|UniProtKB=P24530	Endothelin B receptor	IGI	95240610	PubMed	PTHR24243:SF30	ENDOTHELIN B RECEPTOR
P00021	FGF signaling pathway	P00641	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	PANTR|Ensembl=ENSPTRG00000013628|UniProtKB=H2R4F5	Uncharacterized protein	ISS	12787506	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	ARATH|TAIR=AT4G36250|UniProtKB=Q70E96	Aldehyde dehydrogenase family 3 member F1	IC			PTHR43570:SF17	ALDEHYDE DEHYDROGENASE FAMILY 3 MEMBER F1
P00022	General transcription by RNA polymerase I	P00657	TBP	RAT|RGD=67398|UniProtKB=Q66HB1	Protein Tbp	ISS	600075	OMIM	PTHR10126:SF20	TATA-BOX-BINDING PROTEIN
P00012	Cadherin signaling pathway	P00470	F-actin	ORNAN|Ensembl=ENSOANG00000007405|UniProtKB=F7CIV4	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00624	14-3-3	CANLF|Ensembl=ENSCAFG00000000580|UniProtKB=F1PBL1	Uncharacterized protein	ISS	1499718	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00014	Cholesterol biosynthesis	P00498	Hydroxymethyl glutaryl CoA synthase	PANTR|Ensembl=ENSPTRG00000016845|UniProtKB=H2QQU5	3-hydroxy-3-methylglutaryl-CoA synthase 1 (Soluble)	ISS	123332	gi	PTHR43323:SF4	HYDROXYMETHYLGLUTARYL-COA SYNTHASE, CYTOPLASMIC
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00029	Huntington disease	P00807	Actin	CHICK|Ensembl=ENSGALG00000009621|UniProtKB=P60706	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00037	Ionotropic glutamate receptor pathway	P01020	NSF	MOUSE|MGI=MGI=104560|UniProtKB=P46460	Vesicle-fusing ATPase	ISS	11348590	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00019	Endothelin signaling pathway	P00589	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IGI	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	CAEEL|WormBase=WBGene00006389|UniProtKB=Q9NEW8	TAF (TBP-associated transcription factor) family	ISS			PTHR12228:SF0	TAF7 RNA POLYMERASE II, TATA BOX BINDING PROTEIN  TBP -ASSOCIATED FACTOR
P02784	Tyrosine biosynthesis	P03214	Prephenate dehydrogenase	THEMA|EnsemblGenome=TM_0344|UniProtKB=Q9WYH9	Prephenate dehydrogenase	ISS			PTHR21363:SF0	PREPHENATE DEHYDROGENASE  NADP +
P00048	PI3 kinase pathway	P01202	p85	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00052	TGF-beta signaling pathway	P01287	BAMBI	PANTR|Ensembl=ENSPTRG00000002389|UniProtKB=H2Q1S3	Uncharacterized protein	ISS	10519551	PubMed	PTHR15505:SF1	BMP AND ACTIVIN MEMBRANE-BOUND INHIBITOR HOMOLOG
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00047	PDGF signaling pathway	P01173	STAT	HUMAN|HGNC=11368|UniProtKB=P42226	Signal transducer and activator of transcription 6	ISS	94367369	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P04393	Ras Pathway	P04557	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	IDA	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00009	Axon guidance mediated by netrin	P00364	cdc42	XENTR|Xenbase=XB-GENE-967585|UniProtKB=Q28BZ0	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00048	PI3 kinase pathway	P01177	P110ACT	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05916	Opioid prodynorphin pathway	P06001	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	HALSA|EnsemblGenome=VNG_0734G|UniProtKB=Q9HRE6	Transcription initiation factor IIB 2	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00029	Huntington disease	P00805	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IDA	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000024633|UniProtKB=F1MBU9	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00053	T cell activation	P01306	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01446	Calcineurin	MACMU|Ensembl=ENSMMUG00000015714|UniProtKB=F6SFE0	Serine/threonine-protein phosphatase	ISS	12091710	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04494	TSC2	BOVIN|Ensembl=ENSBTAG00000020617|UniProtKB=E1BNT2	Uncharacterized protein	ISS	15249583	PubMed	PTHR10063:SF0	TUBERIN
P00047	PDGF signaling pathway	P01142	p90RSK	RAT|RGD=620676|UniProtKB=F1M7N7	Ribosomal protein S6 kinase	ISS	15526037	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00019	Endothelin signaling pathway	P00582	COX-2	BOVIN|Gene=PTGS2|UniProtKB=O62698	Prostaglandin G/H synthase 2	IGI	21141972	PubMed	PTHR11903:SF8	PROSTAGLANDIN G/H SYNTHASE 2
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	CAEEL|WormBase=WBGene00002363|UniProtKB=G5EGK8	Serine/threonine-protein phosphatase	ISS			PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01417	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01433	SIAH-1	MOUSE|MGI=MGI=108063|UniProtKB=Q06985	E3 ubiquitin-protein ligase SIAH1B	ISS	14985507	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00047	PDGF signaling pathway	P01142	p90RSK	MOUSE|MGI=MGI=1342290|UniProtKB=Q9WUT3	Ribosomal protein S6 kinase alpha-2	ISS	15526037	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01152	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01177	P110ACT	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05913	Enkephalin release	P05972	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	YEAST|SGD=S000005164|UniProtKB=P80210	Adenylosuccinate synthetase	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00036	Interleukin signaling pathway	P00981	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	TAS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	ISS	10188796	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00053	T cell activation	P01311	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	12068308	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00012	Cadherin signaling pathway	P00464	Fyn	MACMU|Ensembl=ENSMMUG00000017017|UniProtKB=F7FVL2	Tyrosine-protein kinase	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=108022|UniProtKB=P70268	Serine/threonine-protein kinase N1	IC	10644715	PubMed	PTHR24356:SF246	SERINE/THREONINE-PROTEIN KINASE N1
P00034	Integrin signalling pathway	P00936	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IPI	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00011	Blood coagulation	P00447	FVIIa	BOVIN|Ensembl=ENSBTAG00000007411|UniProtKB=P22457	Coagulation factor VII	ISS	119765	gi	PTHR44064:SF1	COAGULATION FACTOR VII
P00019	Endothelin signaling pathway	P00570	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P02775	Salvage pyrimidine ribonucleotides	P03151	Uracil phosphoribosyl  transferase	CAEEL|WormBase=WBGene00008131|UniProtKB=Q9U3L5	Uncharacterized protein	ISS			PTHR10285:SF90	URACIL PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P05917	Opioid proopiomelanocortin pathway	P06009	K+ channel	MONDO|Ensembl=ENSMODG00000015769|UniProtKB=F6ZSC2	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00052	TGF-beta signaling pathway	P01275	P38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	TAS	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00059	p53 pathway	G01579	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IGI	14517213	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04393	Ras Pathway	P04572	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01451	Galpha	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	IDA	14765990	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00114	actin	TRYB2|Gene=Tb09.211.0620|UniProtKB=Q38E94	Actin A	IDA			PTHR11937:SF155	ACTIN-5C-RELATED
P04398	p53 pathway feedback loops 2	P04651	Ras	MONDO|Gene=KRAS|UniProtKB=Q07983	GTPase KRas	ISS	3023884	PubMed	PTHR24070:SF186	GTPASE KRAS
P02750	Lipoate_biosynthesis	P03004	Lipoate synthase	RAT|RGD=1307270|UniProtKB=Q5XIH4	Lipoyl synthase, mitochondrial	ISS			PTHR10949:SF0	LIPOYL SYNTHASE, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	PANTR|Ensembl=ENSPTRG00000014922|UniProtKB=H2QML4	Uncharacterized protein	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P02785	Valine biosynthesis	P03216	Acetolactate synthase	BOVIN|Gene=ILVBL|UniProtKB=A6QQT9	Acetolactate synthase-like protein	ISS			PTHR18968:SF155	ACETOLACTATE SYNTHASE-LIKE PROTEIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04665	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00019	Endothelin signaling pathway	P00572	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	EMENI|EnsemblGenome=CADANIAG00004263|UniProtKB=Q8TFN0	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	RAT|RGD=620632|UniProtKB=Q9WVB9	Segment polarity protein dishevelled homolog DVL-1	TAS	11212302	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P00005	Angiogenesis	P00203	Erk	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9836512	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00019	Endothelin signaling pathway	P00589	Akt	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	ISS	12089061	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00879	SOCS	HUMAN|HGNC=29846|UniProtKB=O14512	Suppressor of cytokine signaling 7	ISS	15032587	PubMed	PTHR45052:SF1	SUPPRESSOR OF CYTOKINE SIGNALING 7
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02748	Isoleucine biosynthesis	P02994	Branched chain amino acid aminotransferase	CAEEL|WormBase=WBGene00001149|UniProtKB=P54688	Branched-chain-amino-acid aminotransferase, cytosolic	ISS			PTHR11825:SF44	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MACMU|Ensembl=ENSMMUG00000010392|UniProtKB=F7ASR8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	PUCGT|EnsemblGenome=PGTG_11337|UniProtKB=E3KLJ3	Calmodulin	ISS	3885394	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05734	Synaptic vesicle trafficking	P05779	Synaptobrevin	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04380	Cortocotropin releasing factor receptor signaling pathway	G04671	proopiomelanocortin	DANRE|ZFIN=ZDB-GENE-030513-2|UniProtKB=Q7ZT18	Pro-opiomelanocortin protein	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00005	Angiogenesis	P00249	PAK	ORNAN|Ensembl=ENSOANG00000002406|UniProtKB=F7BAS2	Uncharacterized protein	ISS	11259591	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00029	Huntington disease	P00790	beta-Tubulin	DROME|FlyBase=FBgn0003889|UniProtKB=P61857	Tubulin beta-2 chain	TAS	12932731	PubMed	PTHR11588:SF155	TUBULIN BETA-2 CHAIN
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00038	JAK/STAT signaling pathway	P01031	PIAS	ORNAN|Ensembl=ENSOANG00000013547|UniProtKB=F7DN97	Uncharacterized protein	ISS	8682149	PubMed	PTHR10782:SF11	E3 SUMO-PROTEIN LIGASE PIAS1
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	HUMAN|HGNC=8746|UniProtKB=Q6UW60	Proprotein convertase subtilisin/kexin type 4	IDA			PTHR42884:SF16	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 4
P00029	Huntington disease	P00790	beta-Tubulin	PRIPA|Gene=PPA21758|UniProtKB=H3FHL1	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF89	TUBULIN BETA-4 CHAIN
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P02776	Serine glycine biosynthesis	P03158	Glycine hydroxymethyltransferase	SCHPO|PomBase=SPAC24C9.12c|UniProtKB=O13972	Probable serine hydroxymethyltransferase, cytosolic	ISS			PTHR11680:SF25	SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04393	Ras Pathway	P04566	Stat 1/3	MACMU|Ensembl=ENSMMUG00000010707|UniProtKB=F7G8G5	Signal transducer and activator of transcription	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00038	JAK/STAT signaling pathway	P01027	STAT	HUMAN|HGNC=11366|UniProtKB=P42229	Signal transducer and activator of transcription 5A	ISS	95236292	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	PANTR|Ensembl=ENSPTRG00000013825|UniProtKB=H2RAK4	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P02752	Mannose metabolism	P03019	P-Mannose mutase	PANTR|Ensembl=ENSPTRG00000014432|UniProtKB=H2QLS6	Phosphomannomutase	ISS	11042159	PubMed	PTHR10466:SF1	PHOSPHOMANNOMUTASE 1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00048	PI3 kinase pathway	P01177	P110ACT	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000023940|UniProtKB=F6RFW8	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	HUMAN|HGNC=4224|UniProtKB=O60383	Growth/differentiation factor 9	TAS	9759503	PubMed	PTHR11848:SF19	GROWTH/DIFFERENTIATION FACTOR 9
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	HUMAN|HGNC=1388|UniProtKB=O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	IDA	8386525	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	11319238	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00021	FGF signaling pathway	P00634	MEKK1-5	BOVIN|Ensembl=ENSBTAG00000020079|UniProtKB=F1N3T0	Uncharacterized protein	ISS	12878610	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IDA	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04397	p53 pathway by glucose deprivation	P04636	S6K	MOUSE|MGI=MGI=1270849|UniProtKB=Q8BSK8	Ribosomal protein S6 kinase beta-1	IDA	15116068	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00059	p53 pathway	P04633	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00572	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IGI	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P02762	Pentose phosphate pathway	P03082	Transketolase	RAT|RGD=621036|UniProtKB=P50137	Transketolase	RCA			PTHR43195:SF3	TRANSKETOLASE
P00005	Angiogenesis	P00189	Fzd	XENTR|Xenbase=XB-GENE-479707|UniProtKB=F6QAW3	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF126	FRIZZLED-5
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00018	EGF receptor signaling pathway	P00558	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00029	Huntington disease	P00778	NMDA receptor	HUMAN|HGNC=16767|UniProtKB=Q8TCU5	Glutamate receptor ionotropic, NMDA 3A	IDA	11319238	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	1333286	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IC	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00012	Cadherin signaling pathway	P00475	Frizzled	RAT|RGD=628816|UniProtKB=G3V6L1	Frizzled homolog 6 (Drosophila)	ISS	11212302	PubMed	PTHR11309:SF75	FRIZZLED-6
P00046	Oxidative stress response	P01138	MKK4	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS	9079650	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	HUMAN|HGNC=5292|UniProtKB=P30939	5-hydroxytryptamine receptor 1F	ISS	11701344	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P02775	Salvage pyrimidine ribonucleotides	P03156	CDP kinase	ANOGA|EnsemblGenome=AGAP005209|UniProtKB=Q5TSQ7	Uridine kinase	ISS			PTHR10285:SF123	URIDINE KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01160	IP3 receptor	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02759	Pyridoxal-5-phosphate biosynthesis	P03062	1-Deoxyxylulose-5-phosphate synthase	MYCTU|EnsemblGenome=LH57_18455|UniProtKB=O50408	1-deoxy-D-xylulose-5-phosphate synthase	ISS			PTHR43322:SF6	1-DEOXY-D-XYLULOSE-5-PHOSPHATE SYNTHASE
P00020	FAS signaling pathway	P00615	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00011	Blood coagulation	P00405	FVIII	MACMU|Ensembl=ENSMMUG00000010245|UniProtKB=F6QMC6	Uncharacterized protein	ISS	4503647	gi	PTHR45309:SF1	COAGULATION FACTOR VIII
P00047	PDGF signaling pathway	P01153	GSK3	HUMAN|HGNC=4616|UniProtKB=P49840	Glycogen synthase kinase-3 alpha	ISS	183955	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	MACMU|Ensembl=ENSMMUG00000020474|UniProtKB=F6VRF4	DNA-directed RNA polymerase II subunit RPB3	ISS	2187864	PubMed	PTHR11800:SF2	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	MACMU|Ensembl=ENSMMUG00000005134|UniProtKB=F7DCC0	Uncharacterized protein	ISS			PTHR42884:SF14	NEUROENDOCRINE CONVERTASE 1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00053	T cell activation	P01332	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	12655147	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	15737619	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P06959	CCKR signaling map	G07277	ITGB1	HUMAN|HGNC=6153|UniProtKB=P05556	Integrin beta-1	RCA	16547500	PubMed	PTHR10082:SF28	INTEGRIN BETA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00059	p53 pathway	G04694	p110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00021	FGF signaling pathway	P00628	JNK1-3	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IGI	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	PANTR|Ensembl=ENSPTRG00000000387|UniProtKB=H2PYE3	Ribosomal protein S6 kinase	ISS	15226426	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00048	PI3 kinase pathway	P01189	PTEN	XENTR|Xenbase=XB-GENE-491433|UniProtKB=B1H2U0	Pten protein	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P06959	CCKR signaling map	P07145	Paxillin	HUMAN|HGNC=9718|UniProtKB=P49023	Paxillin	RCA	7794806	PubMed	PTHR24216:SF11	PAXILLIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IC	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	IDA	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00048	PI3 kinase pathway	P01177	P110ACT	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P01486	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	HUMAN|HGNC=16061|UniProtKB=Q9NQU5	Serine/threonine-protein kinase PAK 6	ISS			PTHR24361:SF182	SERINE/THREONINE-PROTEIN KINASE PAK 6
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00011	Blood coagulation	P00458	GP IIIa	CANLF|Ensembl=ENSCAFG00000013735|UniProtKB=F1PPG5	Integrin beta	ISS	5805339	gi	PTHR10082:SF25	INTEGRIN BETA-3
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00048	PI3 kinase pathway	P01177	P110ACT	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MACMU|Ensembl=ENSMMUG00000007027|UniProtKB=F7F210	Alpha-cardiac actin	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00007	Axon guidance mediated by semaphorins	P00341	Rho	PANTR|Ensembl=ENSPTRG00000014922|UniProtKB=H2QML4	Uncharacterized protein	ISS	12039949	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00005	Angiogenesis	P00219	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01275	P38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	TAS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	IC	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01203	p101	MACMU|Ensembl=ENSMMUG00000005792|UniProtKB=F6VTR8	Uncharacterized protein	ISS	129387	gi	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00019	Endothelin signaling pathway	P00567	PKG	DANRE|ZFIN=ZDB-GENE-080225-40|UniProtKB=F1R125	Uncharacterized protein	ISS	9099696	PubMed	PTHR24353:SF68	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00973	PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01284	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00053	T cell activation	P01303	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	4504111	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00006	Apoptosis signaling pathway	P00286	AIF	DROME|FlyBase=FBgn0031392|UniProtKB=Q9VQ79	Putative apoptosis-inducing factor 1, mitochondrial	IDA	9989411	PubMed	PTHR43557:SF4	APOPTOSIS-INDUCING FACTOR 1, MITOCHONDRIAL
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00057	Wnt signaling pathway	P01440	Cadherin	RAT|RGD=1306297|UniProtKB=D4ADD1	Protein Pcdh20	ISS	8120095	PubMed	PTHR43912:SF7	PROTOCADHERIN-20
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	RCA	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00053	T cell activation	P01316	MHC-antigen	PANTR|Ensembl=ENSPTRG00000034186|UniProtKB=H2QSR5	Uncharacterized protein	ISS	73139	PubMed	PTHR19944:SF59	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DQ ALPHA 1 CHAIN
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00038	JAK/STAT signaling pathway	P01027	STAT	CANLF|Ensembl=ENSCAFG00000015213|UniProtKB=E2RB82	Signal transducer and activator of transcription	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	11545734	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	HUMAN|HGNC=1986|UniProtKB=Q99966	Cbp/p300-interacting transactivator 1	TAS	9865691	PubMed	PTHR17045:SF6	CBP/P300-INTERACTING TRANSACTIVATOR 1
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04547	Ras	DANRE|ZFIN=ZDB-GENE-040808-67|UniProtKB=Q6AZA4	K-ras	ISS	10825661	PubMed	PTHR24070:SF186	GTPASE KRAS
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00034	Integrin signalling pathway	P00936	PI3K	SCHPO|PomBase=SPAC458.05|UniProtKB=P50520	Phosphatidylinositol 3-kinase vps34	IC	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000022319|UniProtKB=F6XDA0	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	BOVIN|Gene=PLCD4|UniProtKB=P21671	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	12860966	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	RAT|RGD=2155|UniProtKB=O88656	Actin-related protein 2/3 complex subunit 1B	ISS	9618202	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	PSEAE|EnsemblGenome=PA5497|UniProtKB=Q9HT76	NrdJa	ISS			PTHR43371:SF1	SUBFAMILY NOT NAMED
P02747	Histidine biosynthesis	P02984	Imidazol glycerol phosphate dehydratase	STRCO|EnsemblGenome=CAB51444|UniProtKB=P16247	Imidazoleglycerol-phosphate dehydratase	ISS			PTHR23133:SF2	IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	CHICK|Gene=PSEN2|UniProtKB=Q90X07	Presenilin-2	IDA	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00006	Apoptosis signaling pathway	P00310	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	HUMAN|HGNC=4045|UniProtKB=O75084	Frizzled-7	TAS	11212302	PubMed	PTHR11309:SF31	FRIZZLED-7
P00021	FGF signaling pathway	P00645	Rac	ORYSJ|EnsemblGenome=OS02G0120800|UniProtKB=Q6ZHA3	Rac-like GTP-binding protein 6	ISS	21948222	PubMed	PTHR24072:SF261	SUBFAMILY NOT NAMED
P05912	Dopamine receptor mediated signaling pathway	P05951	CDK5	MACMU|Ensembl=ENSMMUG00000020451|UniProtKB=F6VZU3	Uncharacterized protein	ISS	10604473,	PubMed	PTHR24056:SF46	CYCLIN-DEPENDENT-LIKE KINASE 5
P02763	Peptidoglycan biosynthesis	P03092	Phospho-N-acetylmuramoyl pentapeptide transferase	BACTN|EnsemblGenome=BT_3451|UniProtKB=Q8A255	Phospho-N-acetylmuramoyl-pentapeptide-transferase	ISS			PTHR22926:SF5	PHOSPHO-N-ACETYLMURAMOYL-PENTAPEPTIDE-TRANSFERASE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00018	EGF receptor signaling pathway	P00557	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IGI	9514948	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00049	Parkinson disease	P01218	alpha-Synuclein	HUMAN|HGNC=11138|UniProtKB=P37840	Alpha-synuclein	TAS	9278044	PubMed	PTHR13820:SF5	ALPHA-SYNUCLEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000015241|UniProtKB=Q5IS72	D(3) dopamine receptor	ISS	11248120	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00029	Huntington disease	P00787	MAPKK4	CHICK|Ensembl=ENSGALG00000001001|UniProtKB=F1P3T1	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00018	EGF receptor signaling pathway	P00547	PP2A	MACMU|Ensembl=ENSMMUG00000013047|UniProtKB=F7H808	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00018	EGF receptor signaling pathway	P00556	PLCgamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00029	Huntington disease	P00790	beta-Tubulin	STRPU|EnsemblGenome=SPU_000062|UniProtKB=W4X9L8	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001749|UniProtKB=H2Q0Q4	Uncharacterized protein	ISS	14624853	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00840	GPRK	RAT|RGD=61986|UniProtKB=P97711	G protein-coupled receptor kinase 6	ISS	12032308	PubMed	PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00048	PI3 kinase pathway	P01192	p110	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00839	SHIP	MACMU|Ensembl=ENSMMUG00000010451|UniProtKB=F7CRA7	Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2	ISS	10381377	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	TAS	3755548	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P02751	Lysine biosynthesis	P03006	Dihydrodipicolinate  reductase	METAC|EnsemblGenome=MA_4474|UniProtKB=Q8THP0	4-hydroxy-tetrahydrodipicolinate reductase	ISS			PTHR20836:SF0	DIHYDRODIPICOLINATE REDUCTASE-LIKE PROTEIN CRR1, CHLOROPLASTIC
P00049	Parkinson disease	P01232	CASK	ORNAN|Ensembl=ENSOANG00000011267|UniProtKB=F7DPD5	Uncharacterized protein	ISS	11679592	PubMed	PTHR23122:SF40	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P00020	FAS signaling pathway	P00603	Pro-Caspase9	HUMAN|HGNC=1511|UniProtKB=P55211	Caspase-9	IGI	9390557	PubMed	PTHR10454:SF157	CASPASE-9
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	TAKRU|Ensembl=ENSTRUG00000012935|UniProtKB=H2U780	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF235	GROWTH DIFFERENTIATION FACTOR 8, LIKE-RELATED
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00005	Angiogenesis	P00243	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00037	Ionotropic glutamate receptor pathway	P00999	PSD95	RAT|RGD=621011|UniProtKB=Q9WV48	SH3 and multiple ankyrin repeat domains protein 1	ISS	20020275	PubMed	PTHR24135:SF3	SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN 1
P00010	B cell activation	P00379	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00029	Huntington disease	P00796	Kainate receptor	PANTR|Gene=GRIK4|UniProtKB=Q5IS46	Glutamate receptor ionotropic, kainate 4	ISS	1648176	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000040329|UniProtKB=F1MMU1	Uncharacterized protein	ISS	12181435	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P04384	Gamma-aminobutyric acid synthesis	P04482	Glutamate decarboxylase	ANOGA|EnsemblGenome=AGAP002425|UniProtKB=Q7QC33	AGAP002425-PA	ISS			PTHR11999:SF114	CYSTEINE SULFINIC ACID DECARBOXYLASE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00010	B cell activation	P00397	IKK	CANLF|Ensembl=ENSCAFG00000005526|UniProtKB=E2RKR0	Uncharacterized protein	ISS	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00034	Integrin signalling pathway	P00950	Paxillin	RAT|RGD=1305759|UniProtKB=Q66H76	Paxillin	ISS	7579684	PubMed	PTHR24216:SF11	PAXILLIN
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01411	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	91232861	PubMed	PTHR24070:SF385	GTPASE HRAS
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00627	ERK1-2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00012	Cadherin signaling pathway	P00475	Frizzled	PANTR|Ensembl=ENSPTRG00000029908|UniProtKB=H2R050	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF90	FRIZZLED-8
P00029	Huntington disease	P00807	Actin	STRPU|EnsemblGenome=SPU_006797|UniProtKB=W4XTP5	Uncharacterized protein	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00034	Integrin signalling pathway	P00931	Integrin beta	HUMAN|Ensembl=ENSG00000259753|UniProtKB=H3BM21	Integrin beta (Fragment)	IDA	3487386	PubMed	PTHR10082:SF25	INTEGRIN BETA-3
P00010	B cell activation	P00386	Calcineurin	MACMU|Ensembl=ENSMMUG00000004599|UniProtKB=F6Q932	Serine/threonine-protein phosphatase	ISS	12091710	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00056	VEGF signaling pathway	P01411	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00046	Oxidative stress response	P01126	ATF2	CANLF|Ensembl=ENSCAFG00000013332|UniProtKB=F1PCQ4	Uncharacterized protein	ISS	11390664	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PANTR|Ensembl=ENSPTRG00000018890|UniProtKB=Q5R1X3	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00059	p53 pathway	P01486	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P06587	Nicotine pharmacodynamics pathway	P06606	ADCY2	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	RCA	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	PANTR|Ensembl=ENSPTRG00000008768|UniProtKB=H2QC98	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF368	MYOSIN-8
P00056	VEGF signaling pathway	P01423	p38MAPK	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P05918	p38 MAPK pathway	P06021	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	10891487	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MOUSE|MGI=MGI=1347361|UniProtKB=O88676	Matrix metalloproteinase-23	TAS	12834808	PubMed	PTHR10201:SF7	MATRIX METALLOPROTEINASE-23
P00016	Cytoskeletal regulation by Rho GTPase	P00521	Profilin	MOUSE|MGI=MGI=97549|UniProtKB=P62962	Profilin-1	ISS			PTHR13936:SF14	PROFILIN-1
P00053	T cell activation	P01307	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000003795|UniProtKB=H2Q3X5	Muscarinic acetylcholine receptor	ISS			PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00113	Erb-B4 transmembrane fragment	HUMAN|HGNC=3432|UniProtKB=Q15303	Receptor tyrosine-protein kinase erbB-4	IDA	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	SCHMA|EnsemblGenome=Smp_161920|UniProtKB=G4VSW5	Putative actin	IC	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00019	Endothelin signaling pathway	P00572	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	TRIAD|EnsemblGenome=TriadG56111|UniProtKB=B3RX77	Non-muscle actin 6.2	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00038	JAK/STAT signaling pathway	P01027	STAT	BOVIN|Gene=STAT3|UniProtKB=P61635	Signal transducer and activator of transcription 3	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MACMU|Ensembl=ENSMMUG00000017345|UniProtKB=F7H9C0	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P02723	Adenine and hypoxanthine salvage pathway	P02812	Deoxyinosine phosphorylase	HUMAN|HGNC=7892|UniProtKB=P00491	Purine nucleoside phosphorylase	ISS			PTHR11904:SF12	PURINE NUCLEOSIDE PHOSPHORYLASE
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	BOVIN|Ensembl=ENSBTAG00000007687|UniProtKB=P55106	Growth/differentiation factor 6	TAS	9759503	PubMed	PTHR11848:SF43	GROWTH/DIFFERENTIATION FACTOR 6
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	ARATH|TAIR=AT3G16980|UniProtKB=Q6NLH0	DNA-directed RNA polymerases II, IV and V subunit 9A	ISS			PTHR11239:SF1	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	RCA	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=68438|UniProtKB=P35370	Nociceptin receptor	IDA	11259498	PubMed	PTHR24229:SF11	NOCICEPTIN RECEPTOR
P00010	B cell activation	P00384	p38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IDA	11707292	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	HUMAN|HGNC=3025|UniProtKB=P21917	D(4) dopamine receptor	ISS	2137198	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00018	EGF receptor signaling pathway	P00543	ERK1-2	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00629	PP2A	DANRE|ZFIN=ZDB-GENE-040426-2487|UniProtKB=Q803G3	Serine/threonine-protein phosphatase	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P02775	Salvage pyrimidine ribonucleotides	P03151	Uracil phosphoribosyl  transferase	ARATH|TAIR=AT4G26510|UniProtKB=O65583	Uridine kinase-like protein 4	ISS			PTHR10285:SF97	URIDINE KINASE-LIKE PROTEIN 3-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	XENTR|Xenbase=XB-GENE-5753573|UniProtKB=F6WKZ2	Uncharacterized protein (Fragment)	ISS	12629106	PubMed	PTHR24241:SF123	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01199	Galpha	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS			PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01199	Galpha	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00029	Huntington disease	P00807	Actin	STRPU|Gene=CYIIIB|UniProtKB=P18499	Actin, cytoskeletal 3B	IDA	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00059	p53 pathway	P04609	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	ARATH|TAIR=AT1G18150|UniProtKB=Q9LM33	Mitogen-activated protein kinase 8	TAS			PTHR24055:SF246	MITOGEN-ACTIVATED PROTEIN KINASE 15-RELATED
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	PANTR|Ensembl=ENSPTRG00000014187|UniProtKB=H2R714	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	IDA	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00019	Endothelin signaling pathway	P00572	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04393	Ras Pathway	P04558	p38	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	IDA	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00047	PDGF signaling pathway	P01153	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	ORNAN|Ensembl=ENSOANG00000003489|UniProtKB=F7FSE3	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00036	Interleukin signaling pathway	P00973	PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04426	K+ channel	RAT|RGD=61997|UniProtKB=O54912	Potassium channel subfamily K member 3	ISS	11875121	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	IPI	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00632	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12539654	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	CRYNJ|EnsemblGenome=CNA02810|UniProtKB=P0CQ42	Ras-like protein	ISS	7997267	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P06664	Gonadotropin-releasing hormone receptor pathway	P06850	PKCs(3)	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00029	Huntington disease	G01535	PIG3	MOUSE|MGI=MGI=1349450|UniProtKB=Q62465	Synaptic vesicle membrane protein VAT-1 homolog	TAS	12932731	PubMed	PTHR44054:SF1	SYNAPTIC VESICLE MEMBRANE PROTEIN VAT-1 HOMOLOG
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00010	B cell activation	P00373	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IGI	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00021	FGF signaling pathway	P00629	PP2A	DANRE|ZFIN=ZDB-GENE-030131-5474|UniProtKB=A2BG80	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B	ISS	137056	PubMed	PTHR11871:SF2	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B ALPHA ISOFORM
P00049	Parkinson disease	P01236	Casein kinase II	HUMAN|HGNC=2459|UniProtKB=P19784	Casein kinase II subunit alpha'	IDA	10617630	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P06664	Gonadotropin-releasing hormone receptor pathway	P06786	ERK1/2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	RCA	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MACMU|Ensembl=ENSMMUG00000015055|UniProtKB=F6TKR2	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF39	BONE MORPHOGENETIC PROTEIN 10
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	BOVIN|Ensembl=ENSBTAG00000011803|UniProtKB=F1MTZ2	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF427	MYOSIN-3
P00057	Wnt signaling pathway	P01457	GBeta	ANOGA|EnsemblGenome=AGAP005911|UniProtKB=Q7Q6D4	AGAP005911-PA	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	8170357	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	MOUSE|MGI=MGI=1321159|UniProtKB=P63330	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	2461222	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01023	CaMKII	MACMU|Ensembl=ENSMMUG00000002433|UniProtKB=F6PKZ8	Uncharacterized protein	ISS	12888804	PubMed	PTHR43940:SF3	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00047	PDGF signaling pathway	P01165	SRF	CANLF|Ensembl=ENSCAFG00000001829|UniProtKB=F1PH12	Uncharacterized protein	ISS	15647354	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01323	I kappa B	BOVIN|Ensembl=ENSBTAG00000016683|UniProtKB=Q8WNW7	NF kappa B inhibitor alpha (Fragment)	ISS	10811867	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	HUMAN|HGNC=1389|UniProtKB=Q00975	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	11976940	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05916	Opioid prodynorphin pathway	P06002	G-protein	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00015	Circadian clock system	P00505	Cry	ORYSJ|EnsemblGenome=OS02G0573200|UniProtKB=Q6YXC2	Cryptochrome 1a	ISS			PTHR11455:SF18	DEOXYRIBODIPYRIMIDINE PHOTO-LYASE, MITOCHONDRIAL
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-040426-2555|UniProtKB=F8W3G9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04376	5HT4 type receptor mediated signaling pathway	P04426	K+ channel	BOVIN|Ensembl=ENSBTAG00000018193|UniProtKB=E1BHX8	Uncharacterized protein	ISS	11875121	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00047	PDGF signaling pathway	P01164	PDK1/2	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	15531926	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00036	Interleukin signaling pathway	P00976	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	ARATH|TAIR=AT3G24090|UniProtKB=Q9LIP9	Glutamine-fructose-6-phosphate transaminase 2	ISS			PTHR10937:SF0	GH12731P-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00023	General transcription regulation	P00658	TBP-associated factors	MACMU|Ensembl=ENSMMUG00000030200|UniProtKB=F7HPQ7	Uncharacterized protein	ISS			PTHR13218:SF15	TAF11-LIKE PROTEIN ENSP00000332601-RELATED
P00021	FGF signaling pathway	P00623	FGF	MOUSE|MGI=MGI=95519|UniProtKB=P15656	Fibroblast growth factor 5	IGI	9786939	PubMed	PTHR11486:SF23	FIBROBLAST GROWTH FACTOR 5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05960	VAT2	HUMAN|HGNC=10935|UniProtKB=Q05940	Synaptic vesicular amine transporter	IC	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	CAEBR|Gene=CBG_05938|UniProtKB=H8WGV2	Protein CBR-ITR-1, isoform a	ISS	12880387	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00006	Apoptosis signaling pathway	P00269	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01425	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	PANTR|Ensembl=ENSPTRG00000024145|UniProtKB=H2PY98	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P04393	Ras Pathway	P04556	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P04393	Ras Pathway	P04545	Sec5	DROME|FlyBase=FBgn0266670|UniProtKB=Q9VQQ9	Exocyst complex component 2	ISS			PTHR13043:SF1	EXOCYST COMPLEX COMPONENT 2
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	TAS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06847	JNK1/2	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	RCA	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00036	Interleukin signaling pathway	P00976	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	TAKRU|Ensembl=ENSTRUG00000014690|UniProtKB=H2UKR9	Uncharacterized protein	IDA	11861492	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00008	Axon guidance mediated by Slit/Robo	P00344	Netrin	CIOIN|Ensembl=ENSCING00000004654|UniProtKB=Q9NL28	Netrin	ISS			PTHR10574:SF357	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00632	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00470	F-actin	CAEBR|Gene=CBG02167|UniProtKB=A8WS37	Protein CBG02167	ISS	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00049	Parkinson disease	P01219	SAPK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	NAS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00006	Apoptosis signaling pathway	P00260	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00049	Parkinson disease	P01224	UbcH7	CANLF|Ensembl=ENSCAFG00000015284|UniProtKB=E2RKT9	Uncharacterized protein	RCA			PTHR24068:SF67	UBIQUITIN-CONJUGATING ENZYME E2 L3
P00036	Interleukin signaling pathway	P00964	p90RSK	BOVIN|Ensembl=ENSBTAG00000014447|UniProtKB=A4IFF4	Ribosomal protein S6 kinase	ISS	15226426	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00019	Endothelin signaling pathway	P00575	furin	CANLF|Ensembl=ENSCAFG00000012353|UniProtKB=E2RSE6	Uncharacterized protein	ISS	95328031	PubMed	PTHR42884:SF1	FURIN
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=1760|UniProtKB=Q9HBT6	Cadherin-20	IDA	8120095	PubMed	PTHR24027:SF84	CADHERIN-20
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00193	SOS-1	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00558	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00018	EGF receptor signaling pathway	P00547	PP2A	CANLF|Ensembl=ENSCAFG00000001753|UniProtKB=F1P714	Uncharacterized protein	ISS	96161994	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01407	Erk	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00010	B cell activation	P00391	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=24667|UniProtKB=Q8TD08	Mitogen-activated protein kinase 15	IDA	10514528	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=1922542|UniProtKB=Q8K1Y2	Serine/threonine-protein kinase D3	ISS	12676944	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04393	Ras Pathway	P04567	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01188	Gbetagamma	ANOGA|EnsemblGenome=AGAP005911|UniProtKB=Q7Q6D4	AGAP005911-PA	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	HUMAN|HGNC=9509|UniProtKB=P49810	Presenilin-2	IDA	12846562	PubMed	PTHR10202:SF13	PRESENILIN-2
P00011	Blood coagulation	P00410	GP IIb	CANLF|Ensembl=ENSCAFG00000014145|UniProtKB=F1PRU9	Uncharacterized protein	ISS	3487386	PubMed	PTHR23220:SF73	INTEGRIN ALPHA-IIB
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00020	FAS signaling pathway	P00615	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	CHICK|Ensembl=ENSGALG00000009705|UniProtKB=F1NSR9	Uncharacterized protein	ISS	15858232	PubMed	PTHR13715:SF16	RYANODINE RECEPTOR 3
P00048	PI3 kinase pathway	P01182	Ras	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CANLF|Gene=GRIN1|UniProtKB=Q5R1P0	Glutamate receptor ionotropic, NMDA 1	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00046	Oxidative stress response	P01135	p38	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	TAS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CAEEL|WormBase=WBGene00001679|UniProtKB=P17343	Guanine nucleotide-binding protein subunit beta-1	IC	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_125401|UniProtKB=C3ZTX6	Putative uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04393	Ras Pathway	P04567	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00547	PP2A	DROME|FlyBase=FBgn0004177|UniProtKB=P23696	Serine/threonine-protein phosphatase PP2A	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00976	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	IC	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00565	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00850	Sos	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04547	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P05915	Opioid proenkephalin pathway	P05994	G-protein	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IGI	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	HUMAN|HGNC=11433|UniProtKB=Q16623	Syntaxin-1A	ISS	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00048	PI3 kinase pathway	P01182	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	RCA	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	HUMAN|HGNC=4583|UniProtKB=Q16478	Glutamate receptor ionotropic, kainate 5	ISS	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DROME|FlyBase=FBgn0014011|UniProtKB=P48554	Ras-related protein Rac2	ISS	12588856	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	RCA	91298951	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00996	STAT	HUMAN|HGNC=11368|UniProtKB=P42226	Signal transducer and activator of transcription 6	IC	94367369	PubMed	PTHR11801:SF48	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	ORYSJ|EnsemblGenome=OS02G0148100|UniProtKB=Q6Z437	Mitogen-activated protein kinase 3	ISS			PTHR24055:SF216	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01415	MAPKAPK2/3	PANTR|Ensembl=ENSPTRG00000001915|UniProtKB=H2Q104	Mitogen-activated protein kinase-activated protein kinase 2	ISS	9628873	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CHICK|Ensembl=ENSGALG00000015683|UniProtKB=E1C795	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00010	B cell activation	P00383	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	RAT|RGD=2343|UniProtKB=P08483	Muscarinic acetylcholine receptor M3	ISS	10069496	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00053	T cell activation	P01312	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IDA	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	XENTR|Xenbase=XB-GENE-491121|UniProtKB=Q6P367	Tubulin, beta 2B	ISS	9454836	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	TAS	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00029	Huntington disease	P00788	Calpain	MOUSE|MGI=MGI=1916793|UniProtKB=Q9D7J7	Calpain small subunit 2	IDA	11675509	PubMed	PTHR44408:SF1	CALPAIN SMALL SUBUNIT 2
P02730	Asparagine and aspartate biosynthesis	P02853	Asparagine synthetase	MOUSE|MGI=MGI=1350929|UniProtKB=Q61024	Asparagine synthetase [glutamine-hydrolyzing]	ISS			PTHR11772:SF23	ASPARAGINE SYNTHETASE  GLUTAMINE-HYDROLYZING
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00056	VEGF signaling pathway	P01421	Rac	PANTR|Ensembl=ENSPTRG00000014488|UniProtKB=H2QLV6	Proline rich 5 (Renal)	ISS			PTHR32428:SF4	PROLINE-RICH PROTEIN 5
P00047	PDGF signaling pathway	P01143	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	18479080	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	BOVIN|Ensembl=ENSBTAG00000015355|UniProtKB=F1MJI8	Uncharacterized protein	ISS	10487978	PubMed	PTHR10749:SF5	PHOSPHORYLASE B KINASE REGULATORY SUBUNIT ALPHA, LIVER ISOFORM
P00046	Oxidative stress response	P01138	MKK4	CHICK|Ensembl=ENSGALG00000001001|UniProtKB=F1P3T1	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000000440|UniProtKB=H2PYH8	Uncharacterized protein	ISS	12093103	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00025	Hedgehog signaling pathway	P00698	Costal2	DROME|FlyBase=FBgn0000352|UniProtKB=O16844	Kinesin-like protein costa	IDA	9244297	PubMed	PTHR24115:SF725	KINESIN-LIKE PROTEIN KIF7
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	MOUSE|MGI=MGI=87979|UniProtKB=Q9WUR9	Adenylate kinase 4, mitochondrial	ISS			PTHR23359:SF58	ADENYLATE KINASE 4, MITOCHONDRIAL
P00049	Parkinson disease	P01242	Casein kinase I	MOUSE|MGI=MGI=1351660|UniProtKB=Q9JMK2	Casein kinase I isoform epsilon	IDA	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00029	Huntington disease	P00807	Actin	CAEBR|Gene=CBG23091|UniProtKB=A8Y4Q9	Protein CBR-ACT-2	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00018	EGF receptor signaling pathway	P00547	PP2A	MONDO|Ensembl=ENSMODG00000014177|UniProtKB=F6U7A6	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00234	Grb2	MOUSE|MGI=MGI=1918770|UniProtKB=Q9CX99	GRB2-related adapter protein	ISS			PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00223	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CANLF|Gene=GRIN1|UniProtKB=Q5R1P0	Glutamate receptor ionotropic, NMDA 1	IC	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	TAKRU|Ensembl=ENSTRUG00000015959|UniProtKB=H2UV27	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00005	Angiogenesis	P00238	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05913	Enkephalin release	P05977	G-Protein (s)	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	IXOSC|EnsemblGenome=ISCW009711|UniProtKB=B7Q3T6	THO complex subunit, putative	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00560	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00380	fos	MONDO|Ensembl=ENSMODG00000005927|UniProtKB=F6WX28	Uncharacterized protein	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	HUMAN|HGNC=4404|UniProtKB=P59768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IDA	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PANTR|Ensembl=ENSPTRG00000008768|UniProtKB=H2QC98	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF368	MYOSIN-8
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=7598|UniProtKB=O94832	Unconventional myosin-Id	ISS			PTHR13140:SF417	UNCONVENTIONAL MYOSIN-ID
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04547	Ras	MONDO|Ensembl=ENSMODG00000025248|UniProtKB=F7F5X1	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00057	Wnt signaling pathway	P01448	CBP	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	PANTR|Ensembl=ENSPTRG00000000437|UniProtKB=H2PYH5	TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa	ISS			PTHR12264:SF21	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12
P00029	Huntington disease	P00807	Actin	PANTR|Ensembl=ENSPTRG00000011990|UniProtKB=H2QHZ9	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P02774	Salvage pyrimidine deoxyribonucleotides	P03144	Cytidine deaminase	YEAST|SGD=S000003572|UniProtKB=P47058	tRNA-specific adenosine deaminase subunit TAD2	ISS			PTHR11079:SF92	TRNA-SPECIFIC ADENOSINE DEAMINASE 2
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CANLF|Ensembl=ENSCAFG00000013332|UniProtKB=F1PCQ4	Uncharacterized protein	ISS	10664585	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00001	Adrenaline and noradrenaline biosynthesis	P00064	NET	PANTR|Ensembl=ENSPTRG00000008126|UniProtKB=H2QB43	Transporter	ISS	97248649	PubMed	PTHR11616:SF37	SODIUM-DEPENDENT NORADRENALINE TRANSPORTER
P00057	Wnt signaling pathway	P01447	Dishevelled	CANLF|Ensembl=ENSCAFG00000016066|UniProtKB=E2R7K2	Uncharacterized protein	ISS	10409711	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00047	PDGF signaling pathway	P01160	IP3 receptor	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PANTR|Ensembl=ENSPTRG00000002086|UniProtKB=H2Q1A9	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	ORYSJ|EnsemblGenome=OS10G0369000|UniProtKB=Q8S5M6	Glutamyl-tRNA synthetase family protein, expressed	ISS			PTHR43097:SF5	GLUTAMATE--TRNA LIGASE, CYTOPLASMIC
P00029	Huntington disease	P00780	Microtubule	STRPU|EnsemblGenome=SPU_007424|UniProtKB=W4XVG8	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF155	TUBULIN BETA-2 CHAIN
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000016097|UniProtKB=E1B9S9	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04393	Ras Pathway	P04547	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P05912	Dopamine receptor mediated signaling pathway	P05957	K+ channel	MONDO|Ensembl=ENSMODG00000015769|UniProtKB=F6ZSC2	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04398	p53 pathway feedback loops 2	P04657	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	MACMU|Ensembl=ENSMMUG00000004797|UniProtKB=F7CL99	CTP synthase	ISS			PTHR11550:SF2	CTP SYNTHASE 2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	BOVIN|Ensembl=ENSBTAG00000020756|UniProtKB=A6QLB8	GSK3A protein	ISS	21361340	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04398	p53 pathway feedback loops 2	G04715	CYCLIN G	HUMAN|HGNC=1592|UniProtKB=P51959	Cyclin-G1	ISS			PTHR10177:SF59	CYCLIN-G1
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00021	FGF signaling pathway	P00634	MEKK1-5	MACMU|Ensembl=ENSMMUG00000016376|UniProtKB=F7G2W1	Uncharacterized protein	ISS	12968034	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00021	FGF signaling pathway	P00629	PP2A	MONDO|Ensembl=ENSMODG00000002866|UniProtKB=F7E2C0	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B	ISS	7918404	PubMed	PTHR11871:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B GAMMA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	PANTR|Ensembl=ENSPTRG00000005197|UniProtKB=A5A6J7	Ras-related protein Rap-1b	ISS	1904317	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00018	EGF receptor signaling pathway	P00557	PI3K	TRYB2|Gene=TB927.1.1930|UniProtKB=Q4GZ26	Phosphatidylinositol 3-kinase, putative	ISS			PTHR11139:SF85	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01162	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	94313981	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00029	Huntington disease	P00807	Actin	TRIVA|Gene=TVAG_512800|UniProtKB=A2HNG1	Actin (Fragment)	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00034	Integrin signalling pathway	P00944	Actin	CANLF|Ensembl=ENSCAFG00000016020|UniProtKB=O18840	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00034	Integrin signalling pathway	P00913	Csk	RAT|RGD=1308800|UniProtKB=P32577	Tyrosine-protein kinase CSK	IDA	7687537	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	MOUSE|MGI=MGI=106217|UniProtKB=Q61290	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	8386525	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00021	FGF signaling pathway	P00645	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00053	T cell activation	P01322	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	HUMAN|HGNC=132|UniProtKB=P60709	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00056	VEGF signaling pathway	P01411	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000022319|UniProtKB=F6XDA0	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P06959	CCKR signaling map	P07079	p38MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	RCA	9727040	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MACMU|Ensembl=ENSMMUG00000021442|UniProtKB=F7EAQ8	Muscarinic acetylcholine receptor	ISS	8100450	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00049	Parkinson disease	P01211	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00591	PLCbeta	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	MOUSE|MGI=MGI=101884|UniProtKB=P35396	Peroxisome proliferator-activated receptor delta	IEP	12356903	PubMed	PTHR24082:SF15	PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DELTA
P00034	Integrin signalling pathway	P00927	Rac	DICDI|dictyBase=DDB_G0268622|UniProtKB=P34145	Rho-related protein rac1B	IGI	21127961	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00012	Cadherin signaling pathway	P00463	betacatenin	DANRE|ZFIN=ZDB-GENE-040426-2575|UniProtKB=E7FC99	Uncharacterized protein	ISS	11532955	PubMed	PTHR23315:SF68	SUBFAMILY NOT NAMED
P00010	B cell activation	P00383	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04379	Beta3 adrenergic receptor signaling pathway	P04450	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00053	T cell activation	P01320	PLC-gamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00807	Actin	ORYSJ|EnsemblGenome=OS10G0510000|UniProtKB=A3C6D7	Actin-2	IDA	11889126	PubMed	PTHR11937:SF252	SUBFAMILY NOT NAMED
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00833	RGS	HUMAN|HGNC=9995|UniProtKB=O14921	Regulator of G-protein signaling 13	IDA	12193720	PubMed	PTHR10845:SF32	REGULATOR OF G-PROTEIN SIGNALING 13
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00034	Integrin signalling pathway	P00922	Collagen	HUMAN|HGNC=2207|UniProtKB=P29400	Collagen alpha-5(IV) chain	IDA	10778855	PubMed	PTHR24023:SF847	COLLAGEN ALPHA-5 IV  CHAIN
P00052	TGF-beta signaling pathway	P01284	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02741	Flavin biosynthesis	P02936	FAD synthetase	ARATH|TAIR=AT4G21470|UniProtKB=Q84MD8	Bifunctional riboflavin kinase/FMN phosphatase	ISS			PTHR22749:SF1	BIFUNCTIONAL RIBOFLAVIN KINASE/FMN PHOSPHATASE
P04393	Ras Pathway	P04565	MKK4/7	HUMAN|HGNC=6844|UniProtKB=P45985	Dual specificity mitogen-activated protein kinase kinase 4	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IC	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	PANTR|Ensembl=ENSPTRG00000004718|UniProtKB=H2Q5I0	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	BOVIN|Ensembl=ENSBTAG00000016420|UniProtKB=Q0VCX4	Catenin beta-1	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04397	p53 pathway by glucose deprivation	P04640	p53	RAT|RGD=620863|UniProtKB=Q9JJP6	Tumor protein 63	TAS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	IXOSC|EnsemblGenome=ISCW009067|UniProtKB=B7Q0X0	Putative uncharacterized protein	ISS			PTHR12458:SF8	CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	ANOGA|EnsemblGenome=AGAP010589|UniProtKB=Q7Q8S4	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF3	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA-RELATED
P00049	Parkinson disease	P01211	ERK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	IDA	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	RAT|RGD=621060|UniProtKB=O88777	Presenilin-2	IDA	9332390	PubMed	PTHR10202:SF13	PRESENILIN-2
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	TAS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00203	Erk	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	IDA	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00805	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01332	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00053	T cell activation	P01312	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IDA	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05731	GABA-B receptor II signaling	P05754	Ggamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00005	Angiogenesis	P00203	Erk	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00048	PI3 kinase pathway	P01182	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00060	Ubiquitin proteasome pathway	P01491	E2	ARATH|TAIR=AT5G41700|UniProtKB=P35131	Ubiquitin-conjugating enzyme E2 8	ISS			PTHR24068:SF78	UBIQUITIN-CONJUGATING ENZYME E2 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=11332|UniProtKB=P32745	Somatostatin receptor type 3	IDA	12181435	PubMed	PTHR24229:SF42	SOMATOSTATIN RECEPTOR TYPE 3
P00057	Wnt signaling pathway	P01438	PP2A	HUMAN|HGNC=9310|UniProtKB=Q15173	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform	IDA	10092233	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01212	p38 MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	NAS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01451	Galpha	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	IDA	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00034	Integrin signalling pathway	P00941	Integrin alpha	MACMU|Ensembl=ENSMMUG00000012659|UniProtKB=F7E7I7	Uncharacterized protein	ISS	386753	gi	PTHR23220:SF73	INTEGRIN ALPHA-IIB
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00006	Apoptosis signaling pathway	P00269	MAPK	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF330	SUBFAMILY NOT NAMED
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00037	Ionotropic glutamate receptor pathway	P01011	EAAT	CAEBR|Gene=CBG14224|UniProtKB=A8XJJ7	Protein CBR-GLT-1	ISS	94365697	PubMed	PTHR11958:SF63	EXCITATORY AMINO ACID TRANSPORTER 2
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	PANTR|Ensembl=ENSPTRG00000006890|UniProtKB=H2Q943	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00009	Axon guidance mediated by netrin	P00356	UNC-5	RAT|RGD=621756|UniProtKB=O08722	Netrin receptor UNC5B	ISS			PTHR12582:SF6	NETRIN RECEPTOR UNC5B
P00049	Parkinson disease	P01211	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00748	Gbeta5L	MACMU|Ensembl=ENSMMUG00000017374|UniProtKB=F7H6T7	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00923	Arf1	TRIAD|EnsemblGenome=TriadG63238|UniProtKB=B3RQZ1	ADP-ribosylation factor 1	ISS	12932731	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=1757|UniProtKB=Q13634	Cadherin-18	IDA	8120095	PubMed	PTHR24027:SF106	CADHERIN-18
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=1310389|UniProtKB=D3ZTF6	Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Predicted), isoform CRA_a	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	DROME|FlyBase=FBgn0001991|UniProtKB=Q24270	Voltage-dependent calcium channel type D subunit alpha-1	ISS	91056091	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT1G01560|UniProtKB=Q9LMM5	Mitogen-activated protein kinase 11	ISS	10851062	PubMed	PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	CANLF|Ensembl=ENSCAFG00000017575|UniProtKB=Q076A5	Myosin-4	ISS	10938134	PubMed	PTHR13140:SF657	MYOSIN-4
P00036	Interleukin signaling pathway	P00990	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05913	Enkephalin release	P05974	G-Protein (i)	ARATH|TAIR=AT4G34460|UniProtKB=P49177	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF48	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA
P00048	PI3 kinase pathway	P01199	Galpha	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02727	Androgen/estrogene/progesterone biosynthesis	P02830	Cholesterol esterase	PANTR|Ensembl=ENSPTRG00000002732|UniProtKB=H2Q287	Lipase	ISS	8146180	PubMed	PTHR11005:SF26	LYSOSOMAL ACID LIPASE/CHOLESTERYL ESTER HYDROLASE
P00052	TGF-beta signaling pathway	P01275	P38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	TAS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04393	Ras Pathway	P04556	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IDA	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00038	JAK/STAT signaling pathway	P01027	STAT	TAKRU|Ensembl=ENSTRUG00000015348|UniProtKB=H2UQK9	Signal transducer and activator of transcription	ISS	11879641	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	TAS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00036	Interleukin signaling pathway	P00965	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00194	Paxillin	CAEBR|Gene=CBG09041|UniProtKB=A8X7Y4	Protein CBR-PXL-1	ISS			PTHR24216:SF8	PAXILLIN, ISOFORM F
P00019	Endothelin signaling pathway	P00587	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	ENTHI|EnsemblGenome=EHI_060340|UniProtKB=Q401L7	Cysteine synthase 3	ISS			PTHR10314:SF131	CYSTEINE SYNTHASE 1
P00019	Endothelin signaling pathway	P00570	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00049	Parkinson disease	P01237	Complex I	DROME|FlyBase=FBgn0030853|UniProtKB=Q9VX36	NADH dehydrogenase (Ubiquinone) 24 kDa subunit, isoform A	TAS	3100899	PubMed	PTHR10371:SF3	NADH DEHYDROGENASE  UBIQUINONE  FLAVOPROTEIN 2, MITOCHONDRIAL
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P04615	MTA2	HUMAN|HGNC=7411|UniProtKB=O94776	Metastasis-associated protein MTA2	IDA	11099047	PubMed	PTHR10865:SF4	METASTASIS-ASSOCIATED PROTEIN MTA2
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04398	p53 pathway feedback loops 2	P04649	Myc	RAT|RGD=3130|UniProtKB=P09416	Myc proto-oncogene protein	TAS	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00036	Interleukin signaling pathway	P00984	MEK	RAT|RGD=1311192|UniProtKB=A0A0G2K3R1	Protein Map3k4	ISS			PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00012	Cadherin signaling pathway	P00470	F-actin	PHYIT|EnsemblGenome=PITG_15117|UniProtKB=D0NRP9	Actin-like protein	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	TAKRU|Ensembl=ENSTRUG00000014318|UniProtKB=H2UI49	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9406|UniProtKB=Q16513	Serine/threonine-protein kinase N2	IC	10644715	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	ORYSJ|EnsemblGenome=OS01G0185200|UniProtKB=Q5VRX8	Os01g0185200 protein	ISS			PTHR43097:SF6	SUBFAMILY NOT NAMED
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1170702	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00049	Parkinson disease	P01211	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00128	Erb-B4	ORNAN|Ensembl=ENSOANG00000007021|UniProtKB=F7GAV2	Receptor protein-tyrosine kinase	ISS	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	TAS	12885769	PubMed	PTHR10202:SF13	PRESENILIN-2
P04393	Ras Pathway	P04542	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02771	Pyrimidine Metabolism	P03127	Beta-Ureidopropionase	PANTR|Ensembl=ENSPTRG00000014174|UniProtKB=H2QLD8	Uncharacterized protein	ISS	10542323	PubMed	PTHR43674:SF2	BETA-UREIDOPROPIONASE
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05730	Endogenous cannabinoid signaling	P05748	mGluR	MACMU|Ensembl=ENSMMUG00000016428|UniProtKB=F7GU00	Metabotropic glutamate receptor 1 isoform alpha	ISS	12488551	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00018	EGF receptor signaling pathway	P00565	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00018	EGF receptor signaling pathway	P00547	PP2A	DANRE|ZFIN=ZDB-GENE-030904-7|UniProtKB=Q8AXX6	Ppp2r5e2 protein	ISS	10092233	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DROME|FlyBase=FBgn0000047|UniProtKB=P83967	Actin, indirect flight muscle	IC	11889126	PubMed	PTHR11937:SF368	ACTIN, INDIRECT FLIGHT MUSCLE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PHYPA|Gene=PHYPADRAFT_107830|UniProtKB=A9TBG2	Actin 7	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00029	Huntington disease	P00805	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01153	GSK3	MACMU|Ensembl=ENSMMUG00000014597|UniProtKB=F6VAQ6	Glycogen synthase kinase-3 alpha	ISS	2164470	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=24667|UniProtKB=Q8TD08	Mitogen-activated protein kinase 15	TAS	10514528	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00022	General transcription by RNA polymerase I	P00650	TAF-IB	ARATH|TAIR=AT5G15570|UniProtKB=Q9LF25	Bromodomain transcription factor	ISS			PTHR12321:SF53	BROMODOMAIN TRANSCRIPTION FACTOR
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	RAT|RGD=3694|UniProtKB=Q01827	Synaptic vesicular amine transporter	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P05730	Endogenous cannabinoid signaling	P05748	mGluR	PANTR|Ensembl=ENSPTRG00000018684|UniProtKB=C7G3M7	Glutamate receptor, metabotropic 1	ISS	8314195	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	MOUSE|MGI=MGI=1321161|UniProtKB=P62715	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00034	Integrin signalling pathway	P00919	Arf6	DAPPU|EnsemblGenome=DAPPUDRAFT_309391|UniProtKB=E9HCC9	Putative uncharacterized protein	ISS	11752622	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00019	Endothelin signaling pathway	P00570	PKA	STRPU|EnsemblGenome=SPU_018419|UniProtKB=W4YRI6	Uncharacterized protein	ISS	97210759	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P05913	Enkephalin release	P05977	G-Protein (s)	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P02723	Adenine and hypoxanthine salvage pathway	P02809	Xanthine dehydrogenase	MACMU|Ensembl=ENSMMUG00000000561|UniProtKB=F6Y3F0	Uncharacterized protein	ISS	8135849	PubMed	PTHR11908:SF80	XANTHINE DEHYDROGENASE/OXIDASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IDA	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00018	EGF receptor signaling pathway	P00563	Gab	BOVIN|Ensembl=ENSBTAG00000002813|UniProtKB=A6QLU3	GRB2-associated-binding protein 1	ISS	20885508	gi	PTHR12156:SF18	GRB2-ASSOCIATED-BINDING PROTEIN 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00005	Angiogenesis	P00181	SHP2	PANTR|Ensembl=ENSPTRG00000042397|UniProtKB=H2RIH8	Tyrosine-protein phosphatase non-receptor type	ISS	14534538	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00045	Notch signaling pathway	G01541	E(spl)-C genes	MOUSE|MGI=MGI=104876|UniProtKB=P70120	Transcription factor HES-5	TAS	14973298	PubMed	PTHR10985:SF104	TRANSCRIPTION FACTOR HES-5
P02788	Xanthine and guanine salvage pathway	P03248	Deoxyguanosine phosphorylase	CAEBR|Gene=CBG13501|UniProtKB=A8XI15	Purine nucleoside phosphorylase	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	ISS	14526383	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00029	Huntington disease	P00778	NMDA receptor	RAT|RGD=621705|UniProtKB=Q8VHN2	Glutamate receptor ionotropic, NMDA 3B	IDA	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	ISS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00018	EGF receptor signaling pathway	P00547	PP2A	ARATH|TAIR=AT1G69960|UniProtKB=O04951	Serine/threonine-protein phosphatase PP2A-5 catalytic subunit	NAS			PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MONDO|Ensembl=ENSMODG00000020977|UniProtKB=F6S5B1	Uncharacterized protein (Fragment)	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00047	PDGF signaling pathway	P01142	p90RSK	HUMAN|HGNC=10435|UniProtKB=Q9UK32	Ribosomal protein S6 kinase alpha-6	ISS	15632195	PubMed	PTHR24351:SF98	RIBOSOMAL PROTEIN S6 KINASE ALPHA-6
P04398	p53 pathway feedback loops 2	P04657	P110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01411	Ras	CAEEL|WormBase=WBGene00002335|UniProtKB=P22981	Ras protein let-60	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P06664	Gonadotropin-releasing hormone receptor pathway	P06807	gnai	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	RCA	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05730	Endogenous cannabinoid signaling	P05748	mGluR	HUMAN|HGNC=4593|UniProtKB=Q13255	Metabotropic glutamate receptor 1	ISS	12488551	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00008	Axon guidance mediated by Slit/Robo	P00355	Rho	MOUSE|MGI=MGI=1931551|UniProtKB=Q9ER71	Rho-related GTP-binding protein RhoJ	ISS	12932731	PubMed	PTHR24072:SF17	RHO-RELATED GTP-BINDING PROTEIN RHOJ
P02723	Adenine and hypoxanthine salvage pathway	P02811	Adenosine deaminase	YEAST|SGD=S000005085|UniProtKB=P53909	Adenine deaminase	ISS			PTHR43114:SF2	ADENINE DEAMINASE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	DROME|FlyBase=FBgn0024234|UniProtKB=P27091	Protein 60A	TAS	10353905	PubMed	PTHR11848:SF54	PROTEIN 60A-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	DROME|FlyBase=FBgn0004623|UniProtKB=P29829	Guanine nucleotide-binding protein subunit beta-2	ISS	9754712	PubMed	PTHR19850:SF30	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00048	PI3 kinase pathway	P01188	Gbetagamma	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00053	T cell activation	P01320	PLC-gamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04378	Beta2 adrenergic receptor signaling pathway	P04446	AC	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04395	Vasopressin synthesis	P04597	Signal Peptide	DANRE|ZFIN=ZDB-GENE-030407-2|UniProtKB=F8W5D0	Uncharacterized protein (Fragment)	ISS	3768139	PubMed	PTHR11681:SF13	SUBFAMILY NOT NAMED
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	TAS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=1305870|UniProtKB=F7EKI5	Protein Pcdh18	ISS	8120095	PubMed	PTHR24028:SF9	PROTOCADHERIN-18
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	RAT|RGD=2740|UniProtKB=Q62645	Glutamate receptor ionotropic, NMDA 2D	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2D.html	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	ARATH|TAIR=AT1G73960|UniProtKB=Q8LPF0	Transcription initiation factor TFIID subunit 2	ISS			PTHR15137:SF9	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2
P00021	FGF signaling pathway	P00629	PP2A	DANRE|ZFIN=ZDB-GENE-040426-877|UniProtKB=F1Q6Z7	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01294	NFAT	HUMAN|HGNC=7777|UniProtKB=Q12968	Nuclear factor of activated T-cells, cytoplasmic 3	IGI	12787506	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05938	RhoA	XENTR|Xenbase=XB-GENE-489222|UniProtKB=Q28GJ8	Ras homolog gene family, member A	ISS	10556059	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ORYSJ|EnsemblGenome=OS11G0163100|UniProtKB=Q67G20	Actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00047	PDGF signaling pathway	P01153	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04495	TSC1	RAT|RGD=620124|UniProtKB=Q9Z136	Hamartin	ISS	12167664	PubMed	PTHR15154:SF2	HAMARTIN
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	TAS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	HUMAN|HGNC=4393|UniProtKB=P11488	Guanine nucleotide-binding protein G(t) subunit alpha-1	ISS	10188796	PubMed	PTHR10218:SF67	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-1
P00046	Oxidative stress response	P01129	JNK1/2	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00012	Cadherin signaling pathway	P00465	TCF/LEF	BOVIN|Ensembl=ENSBTAG00000010111|UniProtKB=F1MJS2	Uncharacterized protein	ISS	11266476	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00005	Angiogenesis	P00212	EphR	CHICK|Gene=EPHB3|UniProtKB=Q07498	Ephrin type-B receptor 3 (Fragment)	ISS			PTHR24416:SF120	EPHRIN TYPE-B RECEPTOR 3
P00012	Cadherin signaling pathway	P00470	F-actin	ARATH|TAIR=AT2G42100|UniProtKB=Q8RYC2	Putative actin-5	IC	10974003	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00029	Huntington disease	P00811	Arp2/3 complex	CANLF|Ensembl=ENSCAFG00000015094|UniProtKB=F1PT97	Uncharacterized protein	ISS	12473693	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=5286|UniProtKB=P08908	5-hydroxytryptamine receptor 1A	IDA	12181435	PubMed	PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04397	p53 pathway by glucose deprivation	P04641	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00557	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P06664	Gonadotropin-releasing hormone receptor pathway	P06730	Pyk2	MOUSE|MGI=MGI=104908|UniProtKB=Q9QVP9	Protein-tyrosine kinase 2-beta	RCA	12640026	PubMed	PTHR24418:SF94	PROTEIN-TYROSINE KINASE 2-BETA
P00024	Glycolysis	P00679	Aldolase	DANRE|ZFIN=ZDB-GENE-030821-1|UniProtKB=Q8JH70	Fructose-bisphosphate aldolase C-B	ISS	1703244	gi	PTHR11627:SF3	FRUCTOSE-BISPHOSPHATE ALDOLASE C
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00819	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00641	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	BOVIN|Ensembl=ENSBTAG00000006101|UniProtKB=Q58DA0	26S proteasome non-ATPase regulatory subunit 4	ISS	10505793	PubMed	PTHR10223:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00046	Oxidative stress response	P01136	Elk-1	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	11050086	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00010	B cell activation	P00398	IP3R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00025	Hedgehog signaling pathway	P00683	Slimb	ORNAN|Ensembl=ENSOANG00000007791|UniProtKB=F6YUQ2	Uncharacterized protein	ISS	12628165	PubMed	PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00060	Ubiquitin proteasome pathway	P01491	E2	MOUSE|MGI=MGI=1934835|UniProtKB=P61089	Ubiquitin-conjugating enzyme E2 N	ISS			PTHR43902:SF2	UBIQUITIN-CONJUGATING ENZYME E2 N
P06587	Nicotine pharmacodynamics pathway	P06593	CHRNA5	MACMU|Ensembl=ENSMMUG00000010743|UniProtKB=F7G171	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF76	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	ANOGA|EnsemblGenome=AGAP002440|UniProtKB=Q17031	Cdc42 homolog	ISS	12932731	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00034	Integrin signalling pathway	P00941	Integrin alpha	PANTR|Ensembl=ENSPTRG00000016860|UniProtKB=H2QQV6	Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	ISS	3487386	PubMed	PTHR23220:SF23	INTEGRIN ALPHA-2
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ARATH|TAIR=AT1G18150|UniProtKB=Q9LM33	Mitogen-activated protein kinase 8	IDA			PTHR24055:SF246	MITOGEN-ACTIVATED PROTEIN KINASE 15-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	BOVIN|Ensembl=ENSBTAG00000011803|UniProtKB=F1MTZ2	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF427	MYOSIN-3
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	RAT|RGD=1563860|UniProtKB=D3Z8E0	Ribosomal protein S6 kinase	ISS	10480933	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BRAFL|Gene=BRAFLDRAFT_56698|UniProtKB=C3XYC3	Putative uncharacterized protein	IDA	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00060	Ubiquitin proteasome pathway	P01490	E3	SCHPO|PomBase=SPBC16E9.11c|UniProtKB=O14326	E3 ubiquitin-protein ligase pub3	ISS			PTHR11254:SF67	E3 UBIQUITIN-PROTEIN LIGASE NEDD-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IDA	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	MOUSE|MGI=MGI=103576|UniProtKB=P48298	Eotaxin	IDA	12060577	PubMed	PTHR12015:SF146	EOTAXIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00021	FGF signaling pathway	P00640	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05913	Enkephalin release	P05977	G-Protein (s)	SCHMA|EnsemblGenome=Smp_059340|UniProtKB=C4QDC7	Guanine nucleotide-binding protein G(S) subunit alpha (Adenylate cyclase-stimulating G alpha protein),putative	IC			PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00054	Toll receptor signaling pathway	P01360	IKKbeta	RAT|RGD=621375|UniProtKB=Q9QY78	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=109356|UniProtKB=O09044	Synaptosomal-associated protein 23	IC	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00034	Integrin signalling pathway	P00942	Fyn	CANLF|Ensembl=ENSCAFG00000003995|UniProtKB=E2RC09	Tyrosine-protein kinase	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00046	Oxidative stress response	P01132	c-jun	XENTR|Xenbase=XB-GENE-482228|UniProtKB=F6RYL1	Uncharacterized protein	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00006	Apoptosis signaling pathway	P00302	ATF	CHICK|Ensembl=ENSGALG00000008494|UniProtKB=Q7SX83	CAMP response element-binding protein	ISS	1354612	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	TAS	10395542	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00059	p53 pathway	G04694	p110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05963	MAO	RAT|RGD=3041|UniProtKB=P19643	Amine oxidase [flavin-containing] B	ISS	90344230	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01457	GBeta	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00005	Angiogenesis	P00223	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	15621031	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	RAT|RGD=621516|UniProtKB=G3V6P8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00019	Endothelin signaling pathway	P00591	PLCbeta	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	HUMAN|HGNC=9299|UniProtKB=P67775	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01159	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	HUMAN|HGNC=11838|UniProtKB=Q04725	Transducin-like enhancer protein 2	IDA	9783586	PubMed	PTHR10814:SF4	AMINO-TERMINAL ENHANCER OF SPLIT-RELATED
P00018	EGF receptor signaling pathway	P00552	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IGI	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00012	Cadherin signaling pathway	P00470	F-actin	DANRE|ZFIN=ZDB-GENE-030131-172|UniProtKB=Q6IQR3	Actin, alpha, cardiac muscle 1a	IC	14684598	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00057	Wnt signaling pathway	P01451	Galpha	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	10477300	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00005	Angiogenesis	P00238	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P00052	TGF-beta signaling pathway	P01286	TGFbeta	DANRE|ZFIN=ZDB-GENE-030618-1|UniProtKB=F1R741	Uncharacterized protein	ISS	9759503	PubMed	PTHR11848:SF125	TRANSFORMING GROWTH FACTOR BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00539	14-3-3	DANRE|ZFIN=ZDB-GENE-011115-1|UniProtKB=Q6PC29	14-3-3 protein gamma-1	ISS	91108808	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P02748	Isoleucine biosynthesis	P02997	Acetolactate synthase	SULSO|EnsemblGenome=SSO0170|UniProtKB=Q980V7	Acetolactate synthase large subunit homolog (IlvB-1)	ISS			PTHR18968:SF13	ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00029	Huntington disease	P00778	NMDA receptor	BOVIN|Ensembl=ENSBTAG00000047202|UniProtKB=G3N3K3	Uncharacterized protein	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00367	NFAT	MACMU|Ensembl=ENSMMUG00000022596|UniProtKB=F6Z7T2	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF5	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 1
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	RCA	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01435	SWI/SNF	MOUSE|MGI=MGI=1859183|UniProtKB=Q8BJL0	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1	IDA	11532957	PubMed	PTHR10799:SF731	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A-LIKE PROTEIN 1
P00041	Metabotropic glutamate receptor group I pathway	P01058	Homer	PANTR|Ensembl=ENSPTRG00000017026|UniProtKB=H2QR55	Homer homolog 1	ISS	12653978	PubMed	PTHR10918:SF3	HOMER PROTEIN HOMOLOG 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P06959	CCKR signaling map	G06969	HDC	HUMAN|HGNC=4855|UniProtKB=P19113	Histidine decarboxylase	RCA	14670968	PubMed	PTHR11999:SF68	HISTIDINE DECARBOXYLASE
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000016097|UniProtKB=E1B9S9	Uncharacterized protein	ISS	9199552	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00047	PDGF signaling pathway	P01142	p90RSK	MOUSE|MGI=MGI=1342290|UniProtKB=Q9WUT3	Ribosomal protein S6 kinase alpha-2	ISS	1922062	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00029	Huntington disease	P00790	beta-Tubulin	TAKRU|Ensembl=ENSTRUG00000012143|UniProtKB=H2U1C0	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF61	TUBULIN BETA CHAIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01154	Ras	DICPU|Gene=DICPUDRAFT_47179|UniProtKB=F0ZI47	Putative uncharacterized protein rasB	ISS	93205383	PubMed	PTHR24070:SF206	RAS-LIKE PROTEIN RASB
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CANLF|Ensembl=ENSCAFG00000012181|UniProtKB=F2Z4N7	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IGI	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04572	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00030	Hypoxia response via HIF activation	P00819	AKT	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	TAS	22081553	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	DROME|FlyBase=FBgn0001991|UniProtKB=Q24270	Voltage-dependent calcium channel type D subunit alpha-1	IC	91056091	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01142	p90RSK	RAT|RGD=620676|UniProtKB=F1M7N7	Ribosomal protein S6 kinase	ISS	1922062	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00047	PDGF signaling pathway	P01148	Grb2	XENTR|Xenbase=XB-GENE-6085807|UniProtKB=Q66IL5	Nck1 protein	ISS			PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	BOVIN|Ensembl=ENSBTAG00000009269|UniProtKB=F1MCM2	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	RAT|RGD=3272|UniProtKB=P28840	Neuroendocrine convertase 1	IDA			PTHR42884:SF14	NEUROENDOCRINE CONVERTASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P05913	Enkephalin release	P05974	G-Protein (i)	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	10188796	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00005	Angiogenesis	P00245	Rac	HUMAN|HGNC=673|UniProtKB=Q07960	Rho GTPase-activating protein 1	IDA	14724572	PubMed	PTHR23176:SF28	RHO GTPASE-ACTIVATING PROTEIN 1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01438	PP2A	BOVIN|Ensembl=ENSBTAG00000019784|UniProtKB=A4FV68	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	ISS	8703017	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00896	Insulin IGF	MOUSE|MGI=MGI=96434|UniProtKB=P09535	Insulin-like growth factor II	ISS	4504609	gi	PTHR11454:SF10	INSULIN-LIKE GROWTH FACTOR II
P00005	Angiogenesis	P00223	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01161	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00938	Cdc42	HUMAN|HGNC=1736|UniProtKB=P60953	Cell division control protein 42 homolog	IDA	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00010	B cell activation	P00379	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00002	Alpha adrenergic receptor signaling pathway	P00078	Alpha1A/1B/1C	RAT|RGD=2057|UniProtKB=P19328	Alpha-2B adrenergic receptor	IC	6323229	PubMed	PTHR24248:SF26	ALPHA-2B ADRENERGIC RECEPTOR
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00203	Erk	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05916	Opioid prodynorphin pathway	P06002	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	IDA	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00059	p53 pathway	G01563	MDM-2	RAT|RGD=1305332|UniProtKB=A0A0G2JVC1	Protein Mdm2	ISS	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00005	Angiogenesis	P00226	Delta/Serrate	CHICK|Ensembl=ENSGALG00000011182|UniProtKB=F1NRS3	Delta-like protein	ISS			PTHR24044:SF380	DELTA-LIKE PROTEIN 1
P05915	Opioid proenkephalin pathway	P05994	G-protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	PANTR|Gene=CHRNA5|UniProtKB=Q5IS51	Neuronal acetylcholine receptor subunit alpha-5	ISS	85270494	PubMed	PTHR18945:SF76	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5
P00052	TGF-beta signaling pathway	P01287	BAMBI	CHICK|Ensembl=ENSGALG00000025919|UniProtKB=E1AWU3	BMP and activin membrane-bound inhibitor homolog	ISS	10519551	PubMed	PTHR15505:SF1	BMP AND ACTIVIN MEMBRANE-BOUND INHIBITOR HOMOLOG
P05916	Opioid prodynorphin pathway	P06002	G-protein	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	ISS	6438083	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00922	Collagen	PANTR|Ensembl=ENSPTRG00000022171|UniProtKB=H2R4F7	Uncharacterized protein	ISS	10778855	PubMed	PTHR24023:SF533	COLLAGEN ALPHA-6 IV  CHAIN
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	HUMAN|HGNC=10944|UniProtKB=P48664	Excitatory amino acid transporter 4	IC	94365697	PubMed	PTHR11958:SF67	EXCITATORY AMINO ACID TRANSPORTER 4
P00056	VEGF signaling pathway	P01419	Ets	HUMAN|HGNC=3488|UniProtKB=P14921	Protein C-ets-1	IEP	15298723	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00046	Oxidative stress response	P01125	Stat1	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00006	Apoptosis signaling pathway	P00311	GCKR	PANTR|Ensembl=ENSPTRG00000006332|UniProtKB=H2Q8A0	Mitogen-activated protein kinase kinase kinase kinase	ISS			PTHR24361:SF324	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 5
P00006	Apoptosis signaling pathway	P00292	IkappaB	MOUSE|MGI=MGI=104741|UniProtKB=Q9Z1E3	NF-kappa-B inhibitor alpha	ISS	99081292	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CAEBR|Gene=CBG05858|UniProtKB=A8X1H0	Protein CBR-EGL-19 (Fragment)	ISS	8838325	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00021	FGF signaling pathway	P00644	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00056	VEGF signaling pathway	P01411	Ras	DICDI|dictyBase=DDB_G0283537|UniProtKB=P32254	Ras-like protein rasS	ISS	94119591	PubMed	PTHR24070:SF380	RAS-LIKE PROTEIN RASS
P00012	Cadherin signaling pathway	P00477	GSK3beta	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00010	B cell activation	P00383	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ORNAN|Ensembl=ENSOANG00000007405|UniProtKB=F7CIV4	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P02775	Salvage pyrimidine ribonucleotides	P03151	Uracil phosphoribosyl  transferase	FUSNN|EnsemblGenome=FN0483|UniProtKB=Q8RG35	Uracil phosphoribosyltransferase	ISS			PTHR10285:SF46	URACIL PHOSPHORIBOSYLTRANSFERASE, CHLOROPLASTIC
P00049	Parkinson disease	P01211	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00055	Transcription regulation by bZIP transcription factor	P01391	TFIIFalpha	MACMU|Ensembl=ENSMMUG00000007904|UniProtKB=F6PSB1	General transcription factor IIF subunit 1	ISS	12732728	PubMed	PTHR13011:SF0	GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1
P00005	Angiogenesis	P00237	FRP	BOVIN|Ensembl=ENSBTAG00000002107|UniProtKB=A7MB15	FZD1 protein	ISS	11212302	PubMed	PTHR11309:SF81	FRIZZLED-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06709	FOS	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	RCA	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT1G07880|UniProtKB=Q9LQQ9	Mitogen-activated protein kinase 13	ISS	11707292	PubMed	PTHR24055:SF185	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00057	Wnt signaling pathway	P01444	Wnt	XENTR|Xenbase=XB-GENE-493706|UniProtKB=Q28IC7	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P02748	Isoleucine biosynthesis	P02995	Threonine dehydratase	IXOSC|EnsemblGenome=ISCW007433|UniProtKB=B7PUC9	Threonine dehydratase, putative (Fragment)	ISS			PTHR43419:SF8	THREONINE AMMONIA-LYASE
P00005	Angiogenesis	P00187	beta catenin	STRPU|EnsemblGenome=SPU_009155|UniProtKB=W4Y0D3	Uncharacterized protein	ISS			PTHR23315:SF233	ARMADILLO SEGMENT POLARITY PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00049	Parkinson disease	P01242	Casein kinase I	HUMAN|HGNC=20289|UniProtKB=Q8N752	Casein kinase I isoform alpha-like	ISS	10617630	PubMed	PTHR11909:SF139	CASEIN KINASE I ISOFORM ALPHA-LIKE
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	RCA	91072385	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	MACMU|Ensembl=ENSMMUG00000029059|UniProtKB=F6QAX2	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00025	Hedgehog signaling pathway	P00681	Casein kinase I	HUMAN|HGNC=2451|UniProtKB=P48729	Casein kinase I isoform alpha	ISS	11437445	PubMed	PTHR11909:SF84	CASEIN KINASE I ISOFORM ALPHA
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00046	Oxidative stress response	P01135	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	94323764	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000003133|UniProtKB=H2S4L7	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	PANTR|Ensembl=ENSPTRG00000018789|UniProtKB=H2QU10	Uncharacterized protein	ISS	12356903	PubMed	PTHR11267:SF83	BRACHYURY PROTEIN
P06664	Gonadotropin-releasing hormone receptor pathway	P06709	FOS	MOUSE|MGI=MGI=95574|UniProtKB=P01101	Proto-oncogene c-Fos	RCA	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00049	Parkinson disease	P01238	14-3-3	ORNAN|Ensembl=ENSOANG00000007305|UniProtKB=F6XW91	Uncharacterized protein	ISS	12865427	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	IDA	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000020588|UniProtKB=F7C0E0	Uncharacterized protein	ISS	125549	gi	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	BRAFL|Gene=BRAFLDRAFT_113587|UniProtKB=C3ZBE3	Putative uncharacterized protein	ISS	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	CHLRE|EnsemblGenome=CHLREDRAFT_136895|UniProtKB=A8IW00	Glutamine synthetase	ISS			PTHR20852:SF57	GLUTAMINE SYNTHETASE 2 CYTOPLASMIC
P00048	PI3 kinase pathway	P01202	p85	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00023	General transcription regulation	P00658	TBP-associated factors	MACMU|Ensembl=ENSMMUG00000012470|UniProtKB=F7G0B2	Uncharacterized protein	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	LEIMA|EnsemblGenome=LmjF.18.1080|UniProtKB=Q27687	Protein kinase A catalytic subunit	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MACMU|Ensembl=ENSMMUG00000001820|UniProtKB=F7AG67	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF27	REGULATOR OF G-PROTEIN SIGNALING 6
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00023	General transcription regulation	P00668	TFIIB	ARATH|TAIR=AT4G36650|UniProtKB=O23215	Plant-specific TFIIB-related protein 1	ISS	180660	OMIM	PTHR11618:SF26	PLANT-SPECIFIC TFIIB-RELATED PROTEIN 1
P00047	PDGF signaling pathway	P01168	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	DROME|FlyBase=FBgn0039747|UniProtKB=Q9VAA2	Adenosine receptor, isoform A	IDA	12515326	PubMed	PTHR24246:SF27	ADENOSINE RECEPTOR A2A
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00047	PDGF signaling pathway	P01143	ERK	CANLF|Ensembl=ENSCAFG00000015640|UniProtKB=E2QVF3	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00053	T cell activation	P01311	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	ARATH|TAIR=AT2G16370|UniProtKB=Q05762	Bifunctional dihydrofolate reductase-thymidylate synthase 1	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P02757	O-antigen biosynthesis	P03052	N-acetylglucosamine-1-phosphate uridyltransferase	FUSNN|EnsemblGenome=FN1991|UniProtKB=Q8RHM3	Bifunctional protein GlmU	ISS			PTHR43584:SF3	BIFUNCTIONAL PROTEIN GLMU
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00029	Huntington disease	P00807	Actin	CANLF|Ensembl=ENSCAFG00000016020|UniProtKB=O18840	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	ARATH|TAIR=AT5G43320|UniProtKB=Q9LSX4	Casein kinase 1-like protein 8	IDA	11437445	PubMed	PTHR11909:SF178	CASEIN KINASE 1-LIKE PROTEIN 8
P00048	PI3 kinase pathway	P01199	Galpha	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04379	Beta3 adrenergic receptor signaling pathway	P04449	Beta3	PANTR|Ensembl=ENSPTRG00000024086|UniProtKB=H2R1M3	Uncharacterized protein	ISS	11943840	PubMed	PTHR24248:SF3	BETA-3 ADRENERGIC RECEPTOR
P04398	p53 pathway feedback loops 2	P04668	p53	RAT|RGD=620863|UniProtKB=Q9JJP6	Tumor protein 63	TAS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	DROME|FlyBase=FBgn0003887|UniProtKB=Q24560	Tubulin beta-1 chain	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04386	Histamine H2 receptor mediated signaling pathway	P04489	H2	PANTR|Ensembl=ENSPTRG00000017551|UniProtKB=P60021	Histamine H2 receptor	ISS	11841575	PubMed	PTHR43893:SF5	HISTAMINE H2 RECEPTOR
P00021	FGF signaling pathway	P00641	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00006	Apoptosis signaling pathway	P00310	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-8365|UniProtKB=Q6TNT8	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00047	PDGF signaling pathway	P01142	p90RSK	MACMU|Ensembl=ENSMMUG00000022111|UniProtKB=F7H7W3	Ribosomal protein S6 kinase	ISS	15226426	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04559	Rac	DROME|FlyBase=FBgn0014011|UniProtKB=P48554	Ras-related protein Rac2	IDA	12588856	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00057	Wnt signaling pathway	P01440	Cadherin	CAEEL|EnsemblGenome=WBGene00001475|UniProtKB=G5EDK5	FlaMIngo (Cadherin plus 7TM domain) homolog	IDA	8120095	PubMed	PTHR24026:SF51	PROTOCADHERIN-LIKE WING POLARITY PROTEIN STAN
P00048	PI3 kinase pathway	P01192	p110	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CAEEL|WormBase=WBGene00004033|UniProtKB=P90980	Protein kinase C-like 2	IC	2837282	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	ISS	11889139	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P05918	p38 MAPK pathway	P06031	p38alpha	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00015	Circadian clock system	P00502	Casein kinase I	MOUSE|MGI=MGI=1351660|UniProtKB=Q9JMK2	Casein kinase I isoform epsilon	IDA	11865049	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00009	Axon guidance mediated by netrin	P00366	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	8649368	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00017	DNA replication	P00527	Histones	BRAFL|Gene=BRAFLDRAFT_67487|UniProtKB=C3XPT8	Uncharacterized protein	ISS	20448842	PubMed	PTHR11426:SF169	HISTONE H3
P00047	PDGF signaling pathway	P01160	IP3 receptor	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000013498|UniProtKB=Q75Z89	5-hydroxytryptamine receptor 2A	ISS			PTHR24247:SF30	5-HYDROXYTRYPTAMINE RECEPTOR 2A
P04393	Ras Pathway	P04574	PLD	CANLF|Ensembl=ENSCAFG00000015246|UniProtKB=J9P1D8	Uncharacterized protein	ISS	10497874	PubMed	PTHR18896:SF57	PHOSPHOLIPASE D1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00055	Transcription regulation by bZIP transcription factor	P01397	TFIIB	YEAST|SGD=S000006290|UniProtKB=P29055	Transcription initiation factor IIB	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	MACMU|Ensembl=ENSMMUG00000020819|UniProtKB=F7HSM1	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176910	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00005	Angiogenesis	P00231	HSP27	PANTR|Ensembl=ENSPTRG00000013953|UniProtKB=H2QL35	Uncharacterized protein	ISS			PTHR11527:SF36	ALPHA-CRYSTALLIN A CHAIN
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=2652894|UniProtKB=Q80Y86	Mitogen-activated protein kinase 15	ISS	10851062	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00019	Endothelin signaling pathway	P00566	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	14744428	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	CHICK|Ensembl=ENSGALG00000017350|UniProtKB=E1C4Q0	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	PANTR|Gene=CHRNA4|UniProtKB=Q5IS77	Neuronal acetylcholine receptor subunit alpha-4	ISS	85270494	PubMed	PTHR18945:SF401	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4
P00056	VEGF signaling pathway	P01408	Akt/PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=1351345|UniProtKB=P47743	Metabotropic glutamate receptor 8	IDA	12488551	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	IDA	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00055	Transcription regulation by bZIP transcription factor	P01390	TFIIA complex	MOUSE|MGI=MGI=1933289|UniProtKB=Q80ZM7	Transcription initiation factor IIA subunit 2	ISS			PTHR10966:SF0	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_206575|UniProtKB=E9FUX0	Guanine nucleotide binding protein, beta subunit	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	P01486	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00058	mRNA splicing	P01473	U6	HUMAN|HGNC=17348|UniProtKB=O43395	U4/U6 small nuclear ribonucleoprotein Prp3	ISS	9328476	PubMed	PTHR14212:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3
P05731	GABA-B receptor II signaling	P05760	AC	ORNAN|Ensembl=ENSOANG00000011580|UniProtKB=F6ZAV4	Uncharacterized protein	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00029	Huntington disease	P00807	Actin	TRYB2|Gene=Tb09.211.0620|UniProtKB=Q38E94	Actin A	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00849	PTEN	HUMAN|HGNC=9588|UniProtKB=P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	14525948	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	CANLF|Ensembl=ENSCAFG00000013148|UniProtKB=Q5R1P3	Glutamate receptor ionotropic, NMDA 2B	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00057	Wnt signaling pathway	P01430	p53	CANLF|Gene=TP53|UniProtKB=Q29537	Cellular tumor antigen p53	IDA	11099028	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00011	Blood coagulation	P00458	GP IIIa	HUMAN|Ensembl=ENSG00000259753|UniProtKB=H3BM21	Integrin beta (Fragment)	ISS	3487386	PubMed	PTHR10082:SF25	INTEGRIN BETA-3
P05918	p38 MAPK pathway	P06031	p38alpha	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P06664	Gonadotropin-releasing hormone receptor pathway	P06850	PKCs(3)	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	RCA	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00010	B cell activation	P00373	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IGI	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	DANRE|ZFIN=ZDB-GENE-051202-1|UniProtKB=E7F101	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF2	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-040426-2855|UniProtKB=Q803H5	Gnb1l protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00049	Parkinson disease	P01236	Casein kinase II	ORYSJ|EnsemblGenome=OS07G0114400|UniProtKB=Q8H386	Casein kinase II alpha subunit	ISS	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01162	MEK	CAEEL|WormBase=WBGene00003186|UniProtKB=Q10664	Dual specificity mitogen-activated protein kinase kinase mek-2	ISS	176872	OMIM	PTHR24361:SF629	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1
P00038	JAK/STAT signaling pathway	P01027	STAT	MONDO|Ensembl=ENSMODG00000014816|UniProtKB=F7CHH2	Signal transducer and activator of transcription	ISS	96210005	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00057	Wnt signaling pathway	P01443	Phospholipase C	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00054	Toll receptor signaling pathway	P01380	TLR1,2,6	CHICK|Gene=TLR2-1|UniProtKB=Q9DD78	Toll-like receptor 2 type-1	ISS			PTHR24365:SF17	TOLL-LIKE RECEPTOR 2
P00029	Huntington disease	P00786	ARF	NEUCR|EnsemblGenome=EFNCRG00000006440|UniProtKB=Q7RVM2	ADP-ribosylation factor	ISS	12932731	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00053	T cell activation	P01333	cdc42	DANRE|ZFIN=ZDB-GENE-030131-8783|UniProtKB=Q52WY2	Ras-like protein Cdc42a	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P06664	Gonadotropin-releasing hormone receptor pathway	P06850	PKCs(3)	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CANLF|Ensembl=ENSCAFG00000015708|UniProtKB=F2Z4N0	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00878	INFgamma	BOVIN|Ensembl=ENSBTAG00000012529|UniProtKB=P07353	Interferon gamma	TAS	11929133	PubMed	PTHR11419:SF0	INTERFERON GAMMA
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	HUMAN|HGNC=2514|UniProtKB=P35222	Catenin beta-1	TAS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00049	Parkinson disease	P01211	ERK	HUMAN|HGNC=6880|UniProtKB=Q13164	Mitogen-activated protein kinase 7	IDA	15085193	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01417	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15601844	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00054	Toll receptor signaling pathway	P01353	TANK	MACMU|Ensembl=ENSMMUG00000001680|UniProtKB=F7G3B1	TRAF family member-associated NF-kappa-B activator isoform a	ISS			PTHR15249:SF0	TRAF FAMILY MEMBER-ASSOCIATED NF-KAPPA-B ACTIVATOR
P00018	EGF receptor signaling pathway	P00539	14-3-3	CANLF|Ensembl=ENSCAFG00000003386|UniProtKB=F6Y478	Uncharacterized protein	ISS	7603573	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	RCA	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00045	Notch signaling pathway	P01115	Neurotic	MOUSE|MGI=MGI=2153207|UniProtKB=Q91ZW2	GDP-fucose protein O-fucosyltransferase 1	RCA			PTHR21420:SF3	GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00020	FAS signaling pathway	P00615	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00054	Toll receptor signaling pathway	P01375	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	ISS	11707292	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00053	T cell activation	P01300	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00029	Huntington disease	P00805	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=3036262|UniProtKB=Q3USB7	Inactive phospholipase C-like protein 1	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P00048	PI3 kinase pathway	P01198	FOXO	HUMAN|HGNC=3821|UniProtKB=O43524	Forkhead box protein O3	TAS	15031210	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01143	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01443	Phospholipase C	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	11832947	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00018	EGF receptor signaling pathway	P00550	Grb2	DANRE|ZFIN=ZDB-GENE-040426-1975|UniProtKB=Q6PC73	Growth factor receptor-bound protein 2	ISS	4504111	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00038	JAK/STAT signaling pathway	P01027	STAT	MONDO|Ensembl=ENSMODG00000014816|UniProtKB=F7CHH2	Signal transducer and activator of transcription	ISS	22320921	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02738	De novo purine biosynthesis	P02907	dADP kinase	MOUSE|MGI=MGI=2449121|UniProtKB=Q9QXL8	Nucleoside diphosphate kinase 7	ISS			PTHR43109:SF2	NUCLEOSIDE DIPHOSPHATE KINASE 7
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CHICK|Ensembl=ENSGALG00000013576|UniProtKB=P49285	Melatonin receptor type 1A	IDA			PTHR43962:SF2	MELATONIN RECEPTOR TYPE 1A
P00019	Endothelin signaling pathway	P00572	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00036	Interleukin signaling pathway	P00983	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	TAS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	HUMAN|HGNC=9558|UniProtKB=Q9UNM6	26S proteasome non-ATPase regulatory subunit 13	ISS	10225435	PubMed	PTHR10539:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01160	IP3 receptor	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	HUMAN|HGNC=1953|UniProtKB=P08173	Muscarinic acetylcholine receptor M4	TAS	10069496	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P04393	Ras Pathway	P04559	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00059	p53 pathway	P04609	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00580	ET-RA/B	MACMU|Ensembl=ENSMMUG00000003659|UniProtKB=F7HSF3	Endothelin-1 receptor isoform a	ISS	12875994	PubMed	PTHR24243:SF31	ENDOTHELIN-1 RECEPTOR
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	ISS	11035810	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00029	Huntington disease	P00807	Actin	PRIPA|Gene=PPA19914|UniProtKB=H3FCG4	Uncharacterized protein	ISS			PTHR11937:SF359	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00260	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	RAT|RGD=620023|UniProtKB=P10980	Muscarinic acetylcholine receptor M2	ISS	91373358	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00047	PDGF signaling pathway	P01168	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00005	Angiogenesis	P00206	Wnt	MACMU|Ensembl=ENSMMUG00000018445|UniProtKB=F7HEW6	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00053	T cell activation	P01332	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	IDA	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	HUMAN|HGNC=2456|UniProtKB=Q9Y6M4	Casein kinase I isoform gamma-3	IDA	10617630	PubMed	PTHR11909:SF151	CASEIN KINASE I ISOFORM GAMMA-3
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00056	VEGF signaling pathway	P01425	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	22533439	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P05918	p38 MAPK pathway	P06031	p38alpha	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00047	PDGF signaling pathway	P01154	Ras	DANRE|ZFIN=ZDB-GENE-040808-67|UniProtKB=Q6AZA4	K-ras	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00035	Interferon-gamma signaling pathway	P00960	PTP	BOVIN|Ensembl=ENSBTAG00000020294|UniProtKB=A5D980	Tyrosine-protein phosphatase non-receptor type	ISS	14525967	PubMed	PTHR19134:SF65	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 6
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00057	Wnt signaling pathway	P01451	Galpha	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	IDA	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00048	PI3 kinase pathway	P01181	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MACMU|Ensembl=ENSMMUG00000012054|UniProtKB=F6TII3	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CAEEL|WormBase=WBGene00006454|UniProtKB=G5EEN8	AEX-4	IC			PTHR19305:SF10	AEX-4
P06587	Nicotine pharmacodynamics pathway	P06605	KCNK3/9	PANTR|Ensembl=ENSPTRG00000020614|UniProtKB=H2QWR7	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00005	Angiogenesis	P00219	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00219	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00014	Cholesterol biosynthesis	P00495	Isopentenyl diphosphate delta-isomerase	RAT|RGD=621835|UniProtKB=O35760	Isopentenyl-diphosphate Delta-isomerase 1	ISS	O35586	SPACC	PTHR10885:SF5	ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE 1
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MACMU|Ensembl=ENSMMUG00000013193|UniProtKB=F6XPY4	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF26	MATRIX METALLOPROTEINASE-16
P00036	Interleukin signaling pathway	P00970	Interleukin	MACMU|Gene=IL1A|UniProtKB=P48089	Interleukin-1 alpha	ISS	2989698	PubMed	PTHR45409:SF1	INTERLEUKIN-1 ALPHA
P02770	Pyridoxal phosphate salvage pathway	P03120	Pyridoxamine-5-phosphate oxidase	MACMU|Ensembl=ENSMMUG00000003325|UniProtKB=F7EHD9	Pyridoxine-5'-phosphate oxidase	ISS	14697241	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ORYSJ|Gene=Os01g0866100|UniProtKB=P0C540	Actin-7	IC	10974003	PubMed	PTHR11937:SF205	SUBFAMILY NOT NAMED
P00060	Ubiquitin proteasome pathway	P01491	E2	TAKRU|Ensembl=ENSTRUG00000003392|UniProtKB=H2S6C6	Uncharacterized protein	ISS	10888878	PubMed	PTHR24068:SF116	AT26201P-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P02741	Flavin biosynthesis	P02940	Riboflavin synthase	BACTN|EnsemblGenome=BT_1317|UniProtKB=Q8A857	Riboflavin synthase alpha chain	ISS			PTHR21098:SF0	RIBOFLAVIN SYNTHASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	XENTR|Xenbase=XB-GENE-977853|UniProtKB=F7EBE7	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00931	Integrin beta	CANLF|Ensembl=ENSCAFG00000013735|UniProtKB=F1PPG5	Integrin beta	IDA	5805339	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00059	p53 pathway	G01576	14-3-3	ORNAN|Ensembl=ENSOANG00000006084|UniProtKB=F7BU66	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF14	14-3-3 PROTEIN SIGMA
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00832	STAT	MONDO|Ensembl=ENSMODG00000028212|UniProtKB=F7BYN4	Signal transducer and activator of transcription	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	CANLF|Ensembl=ENSCAFG00000030049|UniProtKB=J9NWQ5	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF311	CALMODULIN
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01465	Ggamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	PANTR|Ensembl=ENSPTRG00000007461|UniProtKB=H2QA34	Furin (Paired basic amino acid cleaving enzyme)	ISS	10956649	PubMed	PTHR42884:SF1	FURIN
P04398	p53 pathway feedback loops 2	P04661	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00866	Cytokine receptor	MOUSE|MGI=MGI=107658|UniProtKB=P33896	Interferon alpha/beta receptor 1	IDA	12163451	PubMed	PTHR20859:SF54	INTERFERON ALPHA/BETA RECEPTOR 1
P00034	Integrin signalling pathway	P00944	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g169611|UniProtKB=A7SEB1	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Gene=DRD2|UniProtKB=P60026	D(2) dopamine receptor	ISS	2137198	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	CHICK|Ensembl=ENSGALG00000001334|UniProtKB=F1NLV4	Uncharacterized protein	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04398	p53 pathway feedback loops 2	P04665	AKT	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	ISS	98382502	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00017	DNA replication	P00534	PCNA	RAT|RGD=3269|UniProtKB=P04961	Proliferating cell nuclear antigen	ISS	12893285	PubMed	PTHR11352:SF0	PROLIFERATING CELL NUCLEAR ANTIGEN
P00004	Alzheimer disease-presenilin pathway	P00148	Erb-B4 N-terminal fragment	MACMU|Ensembl=ENSMMUG00000001674|UniProtKB=F7G3H1	Receptor protein-tyrosine kinase	ISS	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00049	Parkinson disease	P01212	p38 MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P06959	CCKR signaling map	P07228	MAPK1/3	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	RCA	18039929	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	XENTR|Xenbase=XB-GENE-485905|UniProtKB=A4IGV9	Ins protein	ISS			PTHR11454:SF9	INSULIN-RELATED
P00010	B cell activation	P00398	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MOUSE|MGI=MGI=88398|UniProtKB=Q9ERZ3	Muscarinic acetylcholine receptor M3	TAS	12181435	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00059	p53 pathway	P04633	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	ANOGA|EnsemblGenome=AGAP002748|UniProtKB=Q7QCP8	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00054	Toll receptor signaling pathway	P01346	TLR	PANTR|Ensembl=ENSPTRG00000014992|UniProtKB=H2R0S9	Uncharacterized protein	ISS			PTHR24373:SF37	TOLL-LIKE RECEPTOR 9
P00048	PI3 kinase pathway	P01185	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	CAEBR|Gene=CBG09138|UniProtKB=A8X861	Protein CBR-TBP-1	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	BACSU|EnsemblGenome=BSU21810|UniProtKB=P11045	Dihydrofolate reductase	ISS			PTHR22778:SF16	DIHYDROFOLATE REDUCTASE
P00008	Axon guidance mediated by Slit/Robo	P00342	Slit	CANLF|Ensembl=ENSCAFG00000008945|UniProtKB=F1PSS7	Uncharacterized protein	ISS	10432110	PubMed	PTHR24373:SF39	SLIT HOMOLOG 1 PROTEIN
P00029	Huntington disease	P00776	c-Jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MOUSE|MGI=MGI=95823|UniProtKB=Q03391	Glutamate receptor ionotropic, NMDA 2D	IC	11319238	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CANLF|Ensembl=ENSCAFG00000032542|UniProtKB=J9P639	Uncharacterized protein	ISS	11259498	PubMed	PTHR24229:SF1	KAPPA-TYPE OPIOID RECEPTOR
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	MACMU|Ensembl=ENSMMUG00000010173|UniProtKB=F7AGU8	Presenilin	ISS	12736250	PubMed	PTHR10202:SF18	PRESENILIN-1
P00053	T cell activation	P01307	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00052	TGF-beta signaling pathway	P01290	TAB	CANLF|Ensembl=ENSCAFG00000001332|UniProtKB=F1PLP7	Uncharacterized protein	ISS	8638164	PubMed	PTHR13832:SF533	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01067	AChE	CAEBR|Gene=CBG14965|UniProtKB=A8XL40	Carboxylic ester hydrolase	ISS	86008285	PubMed	PTHR43918:SF6	CARBOXYLIC ESTER HYDROLASE
P00034	Integrin signalling pathway	P00951	Jnk	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	IDA	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00021	FGF signaling pathway	P00627	ERK1-2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	MOUSE|MGI=MGI=1343142|UniProtKB=Q9WV32	Actin-related protein 2/3 complex subunit 1B	IDA	12473693	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00057	Wnt signaling pathway	P01446	Calcineurin	HUMAN|HGNC=9317|UniProtKB=P63098	Calcineurin subunit B type 1	IDA	12015605	PubMed	PTHR23056:SF43	CALCINEURIN SUBUNIT B TYPE 1
P00029	Huntington disease	P00786	ARF	CAEBR|Gene=CBG00335|UniProtKB=A8WMU9	Protein CBR-ARF-6	ISS	12932731	PubMed	PTHR11711:SF216	ADP-RIBOSYLATION FACTOR 6
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	BOVIN|Ensembl=ENSBTAG00000000219|UniProtKB=F1MCL3	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P02772	Pyruvate metabolism	P03132	Pyruvate Kinase	PSEAE|EnsemblGenome=PA4329|UniProtKB=Q9HW72	Pyruvate kinase	ISS	10984043	PubMed	PTHR11817:SF17	PYRUVATE KINASE II
P02754	Methylcitrate cycle	P03028	Aconitase	CAEBR|Gene=CBG17361|UniProtKB=A8XQW4	Aconitate hydratase	ISS			PTHR11670:SF1	ACONITATE HYDRATASE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000015240|UniProtKB=F6VUY3	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P05734	Synaptic vesicle trafficking	P05774	NSF	YEAST|SGD=S000000284|UniProtKB=P18759	Vesicular-fusion protein SEC18	TAS	11348590	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P05915	Opioid proenkephalin pathway	P05994	G-protein	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00038	JAK/STAT signaling pathway	P01027	STAT	BOVIN|Gene=STAT3|UniProtKB=P61635	Signal transducer and activator of transcription 3	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00021	FGF signaling pathway	P00644	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04393	Ras Pathway	P04546	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	IDA	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	DANRE|ZFIN=ZDB-GENE-040808-67|UniProtKB=Q6AZA4	K-ras	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	CHICK|Gene_ORFName=RCJMB04_24e7|UniProtKB=P62149	Calmodulin	ISS			PTHR23050:SF311	CALMODULIN
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PHYPA|Gene=PHYPADRAFT_223212|UniProtKB=Q6TYR5	Beta-tubulin 3	ISS	9454836	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	ORNAN|Ensembl=ENSOANG00000005936|UniProtKB=F6PQC9	Uncharacterized protein	ISS	10476970	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00048	PI3 kinase pathway	P01199	Galpha	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00011	Blood coagulation	P00406	Fibrinogen	PANTR|Ensembl=ENSPTRG00000016536|UniProtKB=H2RDH7	Uncharacterized protein	ISS	223170	gi	PTHR19143:SF338	FIBRINOGEN GAMMA CHAIN
P00029	Huntington disease	P00796	Kainate receptor	CANLF|Ensembl=ENSCAFG00000004930|UniProtKB=E2RFB5	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00003	Alzheimer disease-amyloid secretase pathway	P00108	ADAM10	ORNAN|Ensembl=ENSOANG00000009151|UniProtKB=F7EK00	Uncharacterized protein	ISS	10097139	PubMed	PTHR11905:SF4	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 10
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00047	PDGF signaling pathway	P01171	PLCgamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00049	Parkinson disease	P01219	SAPK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	HALSA|EnsemblGenome=VNG_2243G|UniProtKB=Q9HN56	TATA-box-binding protein E	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00029	Huntington disease	G01535	PIG3	METAC|EnsemblGenome=MA_0771|UniProtKB=Q8TSM5	NADPH:quinone reductase	TAS	12932731	PubMed	PTHR43677:SF4	QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2
P00060	Ubiquitin proteasome pathway	P01491	E2	DANRE|ZFIN=ZDB-GENE-030616-72|UniProtKB=Q789K9	Ubiquitin-conjugating enzyme E2A (RAD6 homolog)	ISS			PTHR43898:SF4	UBIQUITIN-CONJUGATING ENZYME E2 A
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	PANTR|Ensembl=ENSPTRG00000020496|UniProtKB=H2QWJ9	Uncharacterized protein	ISS	9718352	PubMed	PTHR11647:SF50	DIHYDROPYRIMIDINASE
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	MACMU|Ensembl=ENSMMUG00000014334|UniProtKB=F7CYY6	Uncharacterized protein	ISS	1319557	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	15737619	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00049	Parkinson disease	P01219	SAPK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P06664	Gonadotropin-releasing hormone receptor pathway	G06891	Junc	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	RCA	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00029	Huntington disease	P00778	NMDA receptor	HUMAN|HGNC=4586|UniProtKB=Q13224	Glutamate receptor ionotropic, NMDA 2B	IDA	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00005	Angiogenesis	P00204	PLD	BOVIN|Gene=PLD2|UniProtKB=Q0V8L6	Phospholipase D2	ISS	9538008	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P00001	Adrenaline and noradrenaline biosynthesis	P00062	TH	TAKRU|Ensembl=ENSTRUG00000014467|UniProtKB=Q6IVY6	Tyrosine hydroxylase 2	ISS	12480184	PubMed	PTHR11473:SF35	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00628	JNK1-3	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS			PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	15572354	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00053	T cell activation	P01300	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	MOUSE|MGI=MGI=109163|UniProtKB=P63078	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	RCA	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00542	EGFR	MOUSE|MGI=MGI=104771|UniProtKB=Q61527	Receptor tyrosine-protein kinase erbB-4	ISS	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	HUMAN|HGNC=285|UniProtKB=P08588	Beta-1 adrenergic receptor	IDA	12730078	PubMed	PTHR24248:SF54	BETA-1 ADRENERGIC RECEPTOR
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	MOUSE|MGI=MGI=99676|UniProtKB=Q80TL1	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02751	Lysine biosynthesis	P03007	Diaminopimelate decarboxylase	AQUAE|EnsemblGenome=aq_1208|UniProtKB=O67262	Diaminopimelate decarboxylase	ISS			PTHR43727:SF2	DIAMINOPIMELATE DECARBOXYLASE 1, CHLOROPLASTIC-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	RCA	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00015	Circadian clock system	P00505	Cry	BOVIN|Ensembl=ENSBTAG00000010149|UniProtKB=F1MXB2	Uncharacterized protein	ISS	14507900	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CHLRE|EnsemblGenome=CHLREDRAFT_24392|UniProtKB=A8JAV1	Actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00030	Hypoxia response via HIF activation	P00814	P300	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	CANLF|Ensembl=ENSCAFG00000004381|UniProtKB=J9JH96	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00049	Parkinson disease	P01212	p38 MAPK	DROME|FlyBase=FBgn0024846|UniProtKB=O61443	Mitogen-activated protein kinase 14B	NAS	11707292	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P02746	Heme biosynthesis	P02972	Ferrochelatase	DEIRA|EnsemblGenome=DR_1131|UniProtKB=Q9RV98	Ferrochelatase	ISS			PTHR11108:SF1	FERROCHELATASE, MITOCHONDRIAL
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IDA	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00516	Ena/VASP	CHICK|Ensembl=ENSGALG00000009303|UniProtKB=F6QJK6	Uncharacterized protein	ISS			PTHR11202:SF1	PROTEIN ENABLED HOMOLOG
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00936	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00059	p53 pathway	G04694	p110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00050	Plasminogen activating cascade	P01255	Plasminogen	MOUSE|MGI=MGI=97620|UniProtKB=P20918	Plasminogen	ISS	11928811	PubMed	PTHR24261:SF5	PLASMINOGEN
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	9166716	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00054	Toll receptor signaling pathway	P01358	ERK1	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	10747026	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	ANOGA|Gene=AgaP_AGAP011360|UniProtKB=Q7Q2V9	AGAP011360-PA (Fragment)	IDA	11742073	PubMed	PTHR11792:SF17	KURTZ ARRESTIN
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IDA	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00018	EGF receptor signaling pathway	P00547	PP2A	XENTR|Xenbase=XB-GENE-484003|UniProtKB=Q6P365	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P06210	Activin beta signaling pathway	P06233	MED	DROME|FlyBase=FBgn0011648|UniProtKB=P42003	Protein mothers against dpp	RCA			PTHR13703:SF40	PROTEIN MOTHERS AGAINST DPP
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CHICK|Ensembl=ENSGALG00000003675|UniProtKB=E1C2U6	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Ensembl=ENSBTAG00000014674|UniProtKB=P41985	Muscarinic acetylcholine receptor M2	ISS	91373358	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	1499560	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00021	FGF signaling pathway	P00648	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	3755548	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P05912	Dopamine receptor mediated signaling pathway	P05959	FLNA	RAT|RGD=1560614|UniProtKB=C0JPT7	Filamin alpha	ISS	9722563	PubMed	PTHR43998:SF6	FILAMIN-A
P04379	Beta3 adrenergic receptor signaling pathway	P04449	Beta3	MOUSE|MGI=MGI=87939|UniProtKB=P25962	Beta-3 adrenergic receptor	ISS	12063255	PubMed	PTHR24248:SF3	BETA-3 ADRENERGIC RECEPTOR
P00036	Interleukin signaling pathway	P00970	Interleukin	PANTR|Ensembl=ENSPTRG00000017261|UniProtKB=H2QRJ2	Uncharacterized protein	ISS			PTHR16926:SF1	INTERLEUKIN-9
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	TAS	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MACMU|Ensembl=ENSMMUG00000000289|UniProtKB=F7A9T0	Uncharacterized protein	ISS	14507926	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00037	Ionotropic glutamate receptor pathway	P01026	KA	RAT|RGD=2735|UniProtKB=Q63273	Glutamate receptor ionotropic, kainate 5	ISS	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P05730	Endogenous cannabinoid signaling	P05746	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00046	Oxidative stress response	P01129	JNK1/2	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	TAS	1171954	gi	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00053	T cell activation	P01332	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00025	Hedgehog signaling pathway	P00690	Cubitus interruptus	DANRE|ZFIN=ZDB-GENE-030321-1|UniProtKB=F1QAC4	Uncharacterized protein	ISS			PTHR19818:SF2	ZINC FINGER PROTEIN GLI1
P00034	Integrin signalling pathway	P00942	Fyn	DANRE|ZFIN=ZDB-GENE-030903-5|UniProtKB=Q6EWH2	Tyrosine-protein kinase fyna	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P02761	Pantothenate biosynthesis	P03069	2-Dehydropantoate reductase	BACSU|EnsemblGenome=BSU15110|UniProtKB=O34661	Probable 2-dehydropantoate 2-reductase	ISS			PTHR43765:SF1	2-DEHYDROPANTOATE 2-REDUCTASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000001384|UniProtKB=F7GL73	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00010	B cell activation	P00372	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DANRE|ZFIN=ZDB-GENE-030131-6503|UniProtKB=Q7ZUC5	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF297	PROTEIN KINASE C DELTA TYPE
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00020	FAS signaling pathway	P00615	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IGI	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00048	PI3 kinase pathway	P01199	Galpha	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IDA	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00059	p53 pathway	G01579	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P02749	Leucine biosynthesis	P03000	Branched chain amino acid aminotransferase	CAEBR|Gene=CBG00050|UniProtKB=A8WM75	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF44	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	STRPU|EnsemblGenome=SPU_018419|UniProtKB=W4YRI6	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	MACMU|Gene=CCL5|UniProtKB=Q8HYQ1	C-C motif chemokine 5	ISS	250208	gi	PTHR12015:SF82	C-C MOTIF CHEMOKINE 5
P04398	p53 pathway feedback loops 2	P04661	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	1171954	gi	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00047	PDGF signaling pathway	P01167	Ets	BOVIN|Ensembl=ENSBTAG00000012460|UniProtKB=Q58DT0	ETS-related transcription factor Elf-5	ISS	15298723	PubMed	PTHR11849:SF15	ETS-RELATED TRANSCRIPTION FACTOR ELF-5
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ORYSJ|EnsemblGenome=OS05G0438800|UniProtKB=Q75HX0	Actin	ISS	10974003	PubMed	PTHR11937:SF248	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05915	Opioid proenkephalin pathway	P05994	G-protein	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	ISS	15860573	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	YEAST|SGD=S000003272|UniProtKB=P14681	Mitogen-activated protein kinase KSS1	ISS	9836510	gi	PTHR24055:SF338	MITOGEN-ACTIVATED PROTEIN KINASE KSS1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05938	RhoA	XENTR|Xenbase=XB-GENE-941426|UniProtKB=Q28HZ4	Novel Rho protein	ISS	10556059	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	IC	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	MONDO|Ensembl=ENSMODG00000011192|UniProtKB=F6SRK5	Uncharacterized protein	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00006	Apoptosis signaling pathway	P00269	MAPK	CHLRE|EnsemblGenome=CHLREDRAFT_193901|UniProtKB=Q9FXT7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	11832947	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ARATH|TAIR=AT3G46520|UniProtKB=P53497	Actin-12	ISS	11889126	PubMed	PTHR11937:SF276	ACTIN-12
P00030	Hypoxia response via HIF activation	P00823	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IGI	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	DAPPU|EnsemblGenome=DAPPUDRAFT_442795|UniProtKB=E9H5Z2	Calmodulin	ISS	9753452	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	MACMU|Ensembl=ENSMMUG00000017431|UniProtKB=F7HPP3	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P02755	Methylmalonyl pathway	P03033	Propionyl-CoA carboxylase	RAT|RGD=3265|UniProtKB=P07633	Propionyl-CoA carboxylase beta chain, mitochondrial	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	HUMAN|HGNC=7881|UniProtKB=P46531	Neurogenic locus notch homolog protein 1	IDA	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	HUMAN|HGNC=13761|UniProtKB=Q9UBG7	Recombining binding protein suppressor of hairless-like protein	NAS			PTHR10665:SF2	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS-LIKE PROTEIN
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	DANRE|ZFIN=ZDB-GENE-040718-93|UniProtKB=Q6DGZ5	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00059	p53 pathway	P04611	P300	PANTR|Ensembl=ENSPTRG00000014418|UniProtKB=H2QLS0	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	HUMAN|HGNC=9508|UniProtKB=P49768	Presenilin-1	TAS	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	RAT|RGD=3380|UniProtKB=P63331	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IPI	176910	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	HUMAN|HGNC=7881|UniProtKB=P46531	Neurogenic locus notch homolog protein 1	IDA	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IGI	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01451	Galpha	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00624	14-3-3	XENTR|Xenbase=XB-GENE-996375|UniProtKB=F7DY42	Uncharacterized protein	ISS	9450960	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	IPI	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	TAS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00029	Huntington disease	P00780	Microtubule	DANRE|ZFIN=ZDB-GENE-050522-384|UniProtKB=F1QKY8	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00005	Angiogenesis	P00243	Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	ISS	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	RCA	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00046	Oxidative stress response	P01123	Bcl-2	HUMAN|HGNC=990|UniProtKB=P10415	Apoptosis regulator Bcl-2	TAS	2250705	PubMed	PTHR11256:SF11	APOPTOSIS REGULATOR BCL-2
P00056	VEGF signaling pathway	P01409	cPLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	ISS	11522612	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IC	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	CHICK|Ensembl=ENSGALG00000000085|UniProtKB=Q5ZIG5	Uncharacterized protein	ISS			PTHR10937:SF2	GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE  ISOMERIZING  1
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00021	FGF signaling pathway	P00641	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00051	TCA cycle	P01270	Malate Dehydrogenase	HUMAN|HGNC=6970|UniProtKB=P40925	Malate dehydrogenase, cytoplasmic	RCA			PTHR23382:SF3	MALATE DEHYDROGENASE, CYTOPLASMIC
P00052	TGF-beta signaling pathway	P01286	TGFbeta	XENTR|Xenbase=XB-GENE-484925|UniProtKB=F6Z923	Uncharacterized protein (Fragment)	ISS	9759503	PubMed	PTHR11848:SF160	GROWTH/DIFFERENTIATION FACTOR 7
P00049	Parkinson disease	P01241	TH	HUMAN|HGNC=11782|UniProtKB=P07101	Tyrosine 3-monooxygenase	TAS	191290	OMIM	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00005	Angiogenesis	P00226	Delta/Serrate	CANLF|Ensembl=ENSCAFG00000005627|UniProtKB=E2QUR0	Delta-like protein	ISS	12826675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00047	PDGF signaling pathway	P01159	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00019	Endothelin signaling pathway	P00586	Gq	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00004	Alzheimer disease-presenilin pathway	P00114	actin	RAT|RGD=1309504|UniProtKB=D3ZRN3	Protein Actbl2	ISS	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00012	Cadherin signaling pathway	P00470	F-actin	TAKRU|Ensembl=ENSTRUG00000005447|UniProtKB=P68142	Actin, cytoplasmic 1	IC	14684598	PubMed	PTHR11937:SF354	SUBFAMILY NOT NAMED
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	MACMU|Ensembl=ENSMMUG00000003707|UniProtKB=F7GDQ6	Receptor protein serine/threonine kinase	ISS	10683140	PubMed	PTHR23255:SF58	ACTIVIN RECEPTOR TYPE-1C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02787	Vitamin B6 metabolism	P03236	Pyridoxamine phosphate oxidase	MOUSE|MGI=MGI=2144151|UniProtKB=Q91XF0	Pyridoxine-5'-phosphate oxidase	ISS	9601034	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P04395	Vasopressin synthesis	P04589	Signal Peptidase	XENTR|Xenbase=XB-GENE-943208|UniProtKB=Q6P7Y4	Signal peptidase complex catalytic subunit SEC11	ISS	2674115	PubMed	PTHR10806:SF8	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11A-RELATED
P00021	FGF signaling pathway	P00627	ERK1-2	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	RAT|RGD=2732|UniProtKB=P22756	Glutamate receptor ionotropic, kainate 1	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00010	B cell activation	P00371	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00057	Wnt signaling pathway	P01428	Frizzled	ANOGA|EnsemblGenome=AGAP010442|UniProtKB=Q7QDV6	AGAP010442-PA	ISS	8717036	PubMed	PTHR11309:SF90	FRIZZLED-8
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00034	Integrin signalling pathway	P00912	Arp2/3	BOVIN|Ensembl=ENSBTAG00000004242|UniProtKB=Q1JP79	Actin-related protein 2/3 complex subunit 1A	ISS	12473693	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04384	Gamma-aminobutyric acid synthesis	P04482	Glutamate decarboxylase	PANTR|Ensembl=ENSPTRG00000002372|UniProtKB=H2Q1R2	Uncharacterized protein	ISS	2247446	PubMed	PTHR11999:SF77	GLUTAMATE DECARBOXYLASE 2
P02747	Histidine biosynthesis	P02990	Histidinol-phosphatase	NEUCR|EnsemblGenome=EFNCRG00000007027|UniProtKB=Q7SAH5	Histidinol-phosphatase	ISS			PTHR21039:SF0	HISTIDINOL-PHOSPHATASE
P00036	Interleukin signaling pathway	P00965	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IC	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	11956331	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P06587	Nicotine pharmacodynamics pathway	P06590	GNG	MOUSE|MGI=MGI=102705|UniProtKB=P63213	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P02744	Fructose galactose metabolism	P02960	Galactokinase	CANAL|CGD=CAL0000446|UniProtKB=Q59VY8	Galactokinase	TAS			PTHR10457:SF7	N-ACETYLGALACTOSAMINE KINASE
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	ORNAN|Ensembl=ENSOANG00000010302|UniProtKB=F6TDQ6	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00053	T cell activation	P01332	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00053	T cell activation	P01300	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04567	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IDA	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00010	B cell activation	P00370	NFkappaB	MOUSE|MGI=MGI=1099800|UniProtKB=Q9WTK5	Nuclear factor NF-kappa-B p100 subunit	IDA	9133421	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00034	Integrin signalling pathway	P00936	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	IPI	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00021	FGF signaling pathway	P00644	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00017	DNA replication	P00527	Histones	PHYIT|EnsemblGenome=PITG_06953|UniProtKB=D0N6W3	Histone H3	ISS	12413958	PubMed	PTHR11426:SF101	HISTONE H3-LIKE CENTROMERIC PROTEIN CID
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00021	FGF signaling pathway	P00632	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IGI	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	MACMU|Ensembl=ENSMMUG00000005147|UniProtKB=O77680	D(1A) dopamine receptor	ISS	11248120	PubMed	PTHR43893:SF10	D 1A  DOPAMINE RECEPTOR
P06587	Nicotine pharmacodynamics pathway	P06605	KCNK3/9	CHICK|Ensembl=ENSGALG00000016193|UniProtKB=E1BYI0	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_126324|UniProtKB=C3XYC2	Putative uncharacterized protein	IC	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00010	B cell activation	P00402	Jnk	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00056	VEGF signaling pathway	P01417	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00807	Actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347740|UniProtKB=E9FXV8	Cytoplasmatic actin	ISS	10974003	PubMed	PTHR11937:SF277	SUBFAMILY NOT NAMED
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000004331|UniProtKB=E2RPB0	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10747026	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00038	JAK/STAT signaling pathway	P01027	STAT	CANLF|Ensembl=ENSCAFG00000015213|UniProtKB=E2RB82	Signal transducer and activator of transcription	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04541	p90RSK	BOVIN|Ensembl=ENSBTAG00000014447|UniProtKB=A4IFF4	Ribosomal protein S6 kinase	ISS	12213813	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8688|UniProtKB=Q9Y5E6	Protocadherin beta-3	IDA	8120095	PubMed	PTHR24028:SF118	PROTOCADHERIN BETA-3
P00034	Integrin signalling pathway	P00920	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PANTR|Ensembl=ENSPTRG00000027750|UniProtKB=H2QS82	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00018	EGF receptor signaling pathway	P00562	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00005	Angiogenesis	P00227	PLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	IDA	P50393	SPACC	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00036	Interleukin signaling pathway	P00983	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANAL|CGD=CAL0005756|UniProtKB=Q5A281	Mitogen-activated protein kinase	IDA	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	18021322	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MACMU|Ensembl=ENSMMUG00000009771|UniProtKB=F6ZHU6	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF681	MYOSIN-4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	ARATH|TAIR=AT3G52400|UniProtKB=Q9SVC2	Syntaxin-122	IC			PTHR19957:SF69	SYNTAXIN-121-RELATED
P00019	Endothelin signaling pathway	P00566	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00007	Axon guidance mediated by semaphorins	P00340	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	4757952	gi	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00029	Huntington disease	P00795	BDNF	BOVIN|Ensembl=ENSBTAG00000008134|UniProtKB=Q95106	Brain-derived neurotrophic factor	ISS	12117585	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P02738	De novo purine biosynthesis	P02905	Amidophosphoribosyl transferase	FUSNN|EnsemblGenome=FN0987|UniProtKB=Q8REV2	Amidophosphoribosyltransferase	ISS			PTHR11907:SF0	AMIDOPHOSPHORIBOSYLTRANSFERASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	PANTR|Ensembl=ENSPTRG00000014922|UniProtKB=H2QML4	Uncharacterized protein	ISS	12169092	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00022	General transcription by RNA polymerase I	P00649	TAF-IC	MACMU|Ensembl=ENSMMUG00000008569|UniProtKB=F6UPU0	Uncharacterized protein	ISS	604905	OMIM	PTHR15319:SF1	TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT C
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00018	EGF receptor signaling pathway	P00539	14-3-3	YEAST|SGD=S000002506|UniProtKB=P34730	Protein BMH2	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00018	EGF receptor signaling pathway	P00547	PP2A	DANRE|ZFIN=ZDB-GENE-040426-2487|UniProtKB=Q803G3	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00828	Galphai	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	RCA			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00089	Pen-2	XENTR|Xenbase=XB-GENE-854651|UniProtKB=Q28GF7	Presenilin enhancer 2 homolog	ISS	12110170	PubMed	PTHR16318:SF0	GAMMA-SECRETASE SUBUNIT PEN-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01070	K+ channel	HUMAN|HGNC=6296|UniProtKB=O43526	Potassium voltage-gated channel subfamily KQT member 2	ISS	12165472	PubMed	PTHR11537:SF6	POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 2
P00012	Cadherin signaling pathway	P00475	Frizzled	CHICK|Ensembl=ENSGALG00000017242|UniProtKB=Q9IA05	Frizzled-4	IDA	8717036	PubMed	PTHR11309:SF23	FRIZZLED-4
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010884|UniProtKB=E2R486	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	DICPU|Gene=DICPUDRAFT_47179|UniProtKB=F0ZI47	Putative uncharacterized protein rasB	ISS	93205383	PubMed	PTHR24070:SF206	RAS-LIKE PROTEIN RASB
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00060	Ubiquitin proteasome pathway	P01491	E2	SCHPO|PomBase=SPAC18B11.07c|UniProtKB=P23566	Ubiquitin-conjugating enzyme E2 2	ISS			PTHR43898:SF1	UBIQUITIN-CONJUGATING ENZYME E2-17 KDA
P00047	PDGF signaling pathway	P01152	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	227170	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00048	PI3 kinase pathway	P01179	PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IC	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04393	Ras Pathway	P04570	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01018	Glu1	BOVIN|Ensembl=ENSBTAG00000005800|UniProtKB=F1N3G8	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P05918	p38 MAPK pathway	P06031	p38alpha	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Gene=PKN1|UniProtKB=A1A4I4	Serine/threonine-protein kinase N1	ISS	10644715	PubMed	PTHR24356:SF246	SERINE/THREONINE-PROTEIN KINASE N1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	HUMAN|HGNC=4574|UniProtKB=P48058	Glutamate receptor 4	ISS	12497607	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00006	Apoptosis signaling pathway	P00283	A1	MACMU|Ensembl=ENSMMUG00000003364|UniProtKB=F7E8W5	Bcl-2-like protein 5	ISS	11964303	PubMed	PTHR11256:SF10	BCL-2-RELATED PROTEIN A1
P00018	EGF receptor signaling pathway	P00559	MEK1-2	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02723	Adenine and hypoxanthine salvage pathway	P02804	Hypoxanthine phosphoribosyl transferase	LEIMA|EnsemblGenome=LmjF.21.0850|UniProtKB=Q4QCC2	Xanthine phosphoribosyltransferase	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P00049	Parkinson disease	P01208	Hsp70	TRYB2|Gene=Tb927.6.3740|UniProtKB=Q585X3	Heat shock 70 kDa protein, mitochondrial, putative	ISS	12150907	PubMed	PTHR19375:SF184	STRESS-70 PROTEIN, MITOCHONDRIAL
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	TAKRU|Ensembl=ENSTRUG00000015959|UniProtKB=H2UV27	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	HUMAN|HGNC=4401|UniProtKB=O14775	Guanine nucleotide-binding protein subunit beta-5	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P02785	Valine biosynthesis	P03218	Dihydroxy isovalerate dehydratase	SCHPO|PomBase=SPAC17G8.06c|UniProtKB=Q10318	Putative dihydroxy-acid dehydratase, mitochondrial	ISS			PTHR21000:SF5	DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL
P00018	EGF receptor signaling pathway	P00539	14-3-3	CANLF|Ensembl=ENSCAFG00000003386|UniProtKB=F6Y478	Uncharacterized protein	ISS	5803227	gi	PTHR18860:SF3	14-3-3 PROTEIN THETA
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IDA	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01238	14-3-3	CANLF|Ensembl=ENSCAFG00000009514|UniProtKB=F1PKW7	Uncharacterized protein	ISS	21864508	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00547	PP2A	ARATH|TAIR=AT4G15415|UniProtKB=Q8RW96	Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' gamma isoform	ISS			PTHR10257:SF27	SERINE/THREONINE PROTEIN PHOSPHATASE 2A 59 KDA REGULATORY SUBUNIT B' GAMMA ISOFORM-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9441|UniProtKB=P51817	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	HUMAN|HGNC=4404|UniProtKB=P59768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IC	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00018	EGF receptor signaling pathway	P00543	ERK1-2	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	HUMAN|HGNC=171|UniProtKB=Q04771	Activin receptor type-1	TAS	9395284	PubMed	PTHR23255:SF69	ACTIVIN RECEPTOR TYPE-1
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04393	Ras Pathway	P04542	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00200	Dsh	CIOIN|Ensembl=ENSCING00000009658|UniProtKB=Q9NL46	Dishevelled homolog	ISS			PTHR10878:SF25	SEGMENT POLARITY PROTEIN DISHEVELLED
P00036	Interleukin signaling pathway	P00965	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	RAT|RGD=2029|UniProtKB=P80203	Serine/threonine-protein kinase receptor R3	TAS	9395284	PubMed	PTHR23255:SF66	SERINE/THREONINE-PROTEIN KINASE RECEPTOR R3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00025	Hedgehog signaling pathway	P00693	Ubiquitin ligase	MONDO|Ensembl=ENSMODG00000005976|UniProtKB=F6VZ48	Uncharacterized protein (Fragment)	ISS			PTHR11254:SF402	E3 UBIQUITIN-PROTEIN LIGASE UBR5
P04397	p53 pathway by glucose deprivation	P04641	Akt	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	ISS	7876156	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00059	p53 pathway	P04633	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	BACSU|EnsemblGenome=BSU17390|UniProtKB=P50621	Ribonucleoside-diphosphate reductase subunit beta	ISS			PTHR23409:SF32	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT BETA
P00021	FGF signaling pathway	P00647	SHP2	CANLF|Ensembl=ENSCAFG00000008894|UniProtKB=F1Q3J6	Tyrosine-protein phosphatase non-receptor type	ISS	7681589	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00036	Interleukin signaling pathway	P00965	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	98269030	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00357	Netrin	MACMU|Ensembl=ENSMMUG00000009397|UniProtKB=F7HEU6	Uncharacterized protein	ISS	11356879	PubMed	PTHR10574:SF365	NETRIN-1
P00006	Apoptosis signaling pathway	P00285	Diva	MACMU|Ensembl=ENSMMUG00000017372|UniProtKB=F7H6U5	Uncharacterized protein	ISS	11557035	PubMed	PTHR11256:SF47	BCL-2-LIKE PROTEIN 10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	BOVIN|Ensembl=ENSBTAG00000011461|UniProtKB=P28190	Adenosine receptor A1	ISS	11781138	PubMed	PTHR24246:SF1	ADENOSINE RECEPTOR A1
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	MOUSE|MGI=MGI=97513|UniProtKB=P23188	Furin	IDA	10956649	PubMed	PTHR42884:SF1	FURIN
P00021	FGF signaling pathway	P00640	PI3K	ARATH|TAIR=AT1G60490|UniProtKB=P42339	Phosphatidylinositol 3-kinase VPS34	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00053	T cell activation	P01323	I kappa B	HUMAN|HGNC=7797|UniProtKB=P25963	NF-kappa-B inhibitor alpha	ISS	10811867	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	MACMU|Ensembl=ENSMMUG00000017923|UniProtKB=F7ES96	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=16267|UniProtKB=Q9UBV4	Protein Wnt-16	IDA	8717036	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P02785	Valine biosynthesis	P03215	Branched chain amino acid aminotransferase	PANTR|Ensembl=ENSPTRG00000011258|UniProtKB=H2QGS7	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF39	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, MITOCHONDRIAL
P00012	Cadherin signaling pathway	P00477	GSK3beta	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00019	Endothelin signaling pathway	P00587	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04552	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CAEBR|Gene=CBG17587|UniProtKB=A8XRA5	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00754	PDEgamma	HUMAN|HGNC=8789|UniProtKB=P18545	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	ISS	3011376	PubMed	PTHR12122:SF4	RETINAL ROD RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT GAMMA
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06699	AC	MOUSE|MGI=MGI=99677|UniProtKB=O88444	Adenylate cyclase type 1	RCA	89298382	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P00018	EGF receptor signaling pathway	P00559	MEK1-2	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IGI	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	TAS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01179	PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01275	P38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00009	Axon guidance mediated by netrin	P00359	NFAT	MOUSE|MGI=MGI=103296|UniProtKB=P97305	Nuclear factor of activated T-cells, cytoplasmic 3	IDA	12787506	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	98189216	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	DICDI|dictyBase=DDB_G0275617|UniProtKB=P26355	TATA-box-binding protein	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00034	Integrin signalling pathway	P00911	B-Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	ISS	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00052	TGF-beta signaling pathway	P01288	FKBP12	PANTR|Ensembl=ENSPTRG00000011708|UniProtKB=H2QHI6	Peptidyl-prolyl cis-trans isomerase	ISS			PTHR10516:SF309	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1B
P00049	Parkinson disease	P01236	Casein kinase II	TRYB2|Gene=Tb09.211.4890|UniProtKB=Q38D21	Casein kinase II, putative	ISS	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P02727	Androgen/estrogene/progesterone biosynthesis	P02833	3beta-Hydroxysteroid dehydrogenase	MOUSE|MGI=MGI=104645|UniProtKB=Q61694	3 beta-hydroxysteroid dehydrogenase type 5	ISS	7491113	PubMed	PTHR10366:SF297	3 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 4-RELATED
P04393	Ras Pathway	P04542	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	ARATH|TAIR=AT1G13890|UniProtKB=Q9LMG8	Putative SNAP25 homologous protein SNAP30	ISS			PTHR19305:SF7	SNAP25 HOMOLOGOUS PROTEIN SNAP30-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DANRE|ZFIN=ZDB-GENE-030131-172|UniProtKB=Q6IQR3	Actin, alpha, cardiac muscle 1a	ISS	11889139	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00019	Endothelin signaling pathway	P00591	PLCbeta	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00019	Endothelin signaling pathway	P00590	IP3 R	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	IGI	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P05734	Synaptic vesicle trafficking	P05779	Synaptobrevin	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IDA	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	IDA	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01305	Calmodulin	ORYSJ|EnsemblGenome=OS05G0491100|UniProtKB=Q6F332	Calmodulin-2	ISS	7514101	PubMed	PTHR23050:SF324	CALMODULIN-2-RELATED
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05917	Opioid proopiomelanocortin pathway	P06006	beta-Endorphin	DANRE|ZFIN=ZDB-GENE-041014-294|UniProtKB=Q5SPP4	Uncharacterized protein	ISS	176830	OMIM	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00011	Blood coagulation	P00458	GP IIIa	CANLF|Ensembl=ENSCAFG00000013735|UniProtKB=F1PPG5	Integrin beta	ISS	484963	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00019	Endothelin signaling pathway	P00572	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00020	FAS signaling pathway	P00610	MKK4	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00005	Angiogenesis	P00238	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00048	PI3 kinase pathway	P01192	p110	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IDA	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00018	EGF receptor signaling pathway	P00561	STAT	DANRE|ZFIN=ZDB-GENE-980526-499|UniProtKB=Q6P943	Signal transducer and activator of transcription	IGI	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000002339|UniProtKB=H2R368	Uncharacterized protein	ISS	20088160	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	DANRE|ZFIN=ZDB-GENE-990415-162|UniProtKB=P52160	Transcriptional regulator Myc-A	IEP	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IGI	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	DICPU|Gene=DICPUDRAFT_90232|UniProtKB=F1A175	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00049	Parkinson disease	P01213	Cyclin E	MOUSE|MGI=MGI=88316|UniProtKB=Q61457	G1/S-specific cyclin-E1	ISS	12628165	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IC	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	ANOGA|EnsemblGenome=AGAP001394|UniProtKB=F5HMS4	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00018	EGF receptor signaling pathway	P00557	PI3K	DROME|FlyBase=FBgn0015278|UniProtKB=Q7K3H0	LD28067p	IGI	8662856	PubMed	PTHR10048:SF64	LD28067P
P00018	EGF receptor signaling pathway	P00564	Rac	ORYSJ|Gene=Os01g0229400|UniProtKB=Q9SSX0	Rac-like GTP-binding protein 1	IGI	12932731	PubMed	PTHR24072:SF154	SUBFAMILY NOT NAMED
P00059	p53 pathway	P04634	Cdc2	PANTR|Ensembl=ENSPTRG00000002528|UniProtKB=H2R7P8	Cyclin-dependent kinase 1	ISS			PTHR24056:SF334	CYCLIN-DEPENDENT KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00036	Interleukin signaling pathway	P00990	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00057	Wnt signaling pathway	P01451	Galpha	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01098	CHT1	RHOBA|EnsemblGenome=RB8472|UniProtKB=Q7UFM6	High affinity choline transporter	RCA			PTHR43291:SF6	SUBFAMILY NOT NAMED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00005	Angiogenesis	P00206	Wnt	MACMU|Ensembl=ENSMMUG00000017345|UniProtKB=F7H9C0	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	BOVIN|Ensembl=ENSBTAG00000018270|UniProtKB=F1MGR9	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P02747	Histidine biosynthesis	P02989	Phosphoribosyl AMP cyclohydrolase	RHOBA|EnsemblGenome=RB5601|UniProtKB=Q7URL1	Phosphoribosyl-ATP pyrophosphatase	ISS			PTHR42945:SF1	HISTIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN HISIE, CHLOROPLASTIC
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IDA	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MONDO|Ensembl=ENSMODG00000004799|UniProtKB=F6VM87	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00925	MEK	HUMAN|HGNC=6843|UniProtKB=P46734	Dual specificity mitogen-activated protein kinase kinase 3	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00010	B cell activation	P00398	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	IGI	11463389	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00036	Interleukin signaling pathway	P00973	PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	BOVIN|Ensembl=ENSBTAG00000011757|UniProtKB=Q9XT97	Presenilin-1	TAS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00021	FGF signaling pathway	P00623	FGF	BOVIN|Ensembl=ENSBTAG00000006722|UniProtKB=F1MHC6	Fibroblast growth factor	ISS	12851399	PubMed	PTHR11486:SF27	FIBROBLAST GROWTH FACTOR 16
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00223	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00807	Actin	HUMAN|HGNC=130|UniProtKB=P62736	Actin, aortic smooth muscle	IDA	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02743	Formyltetrahydroformate biosynthesis	P02953	Cobalamin dependent homocysteine transmethylase	HUMAN|HGNC=7468|UniProtKB=Q99707	Methionine synthase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P02738	De novo purine biosynthesis	P02898	Phosphoribosylformylglycinamide  synthase	RAT|RGD=6485156|UniProtKB=A0A0G2JTN4	Protein LOC100912917	ISS			PTHR10099:SF1	PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MACMU|Ensembl=ENSMMUG00000001458|UniProtKB=F7BKH1	Uncharacterized protein	ISS	9618202	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00053	T cell activation	P01316	MHC-antigen	BOVIN|Ensembl=ENSBTAG00000002581|UniProtKB=A6QQE7	Major histocompatibility complex, class II, DY alpha	IPI	73139	PubMed	PTHR19944:SF59	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DQ ALPHA 1 CHAIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=14546|UniProtKB=Q9NRJ7	Protocadherin beta-16	IDA	8120095	PubMed	PTHR24028:SF71	PROTOCADHERIN BETA-16
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01126	ATF2	BOVIN|Ensembl=ENSBTAG00000002295|UniProtKB=F1N177	Uncharacterized protein	ISS	9819389	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00884	c-fos	PANTR|Ensembl=ENSPTRG00000006553|UniProtKB=A5A6H0	C-fos	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00048	PI3 kinase pathway	P01192	p110	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MACMU|Ensembl=ENSMMUG00000007486|UniProtKB=F6QL95	Frizzled-3	ISS	8717036	PubMed	PTHR11309:SF22	FRIZZLED-3
P00048	PI3 kinase pathway	P01199	Galpha	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00036	Interleukin signaling pathway	P00977	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00204	PLD	ANOGA|EnsemblGenome=AGAP010687|UniProtKB=Q7PRL1	AGAP010687-PA (Fragment)	ISS			PTHR18896:SF76	PHOSPHOLIPASE D2
P00005	Angiogenesis	P00181	SHP2	BOVIN|Ensembl=ENSBTAG00000002048|UniProtKB=F1N339	Tyrosine-protein phosphatase non-receptor type	ISS	95163101	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00036	Interleukin signaling pathway	P00981	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05912	Dopamine receptor mediated signaling pathway	P05963	MAO	CANLF|Ensembl=ENSCAFG00000014435|UniProtKB=P58027	Amine oxidase [flavin-containing] A	ISS	90344230	PubMed	PTHR43563:SF3	AMINE OXIDASE  FLAVIN-CONTAINING  A
P00034	Integrin signalling pathway	P00951	Jnk	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01443	Phospholipase C	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IDA	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00014	Cholesterol biosynthesis	P00491	Hydroxymethyl glutaryl CoA reductase	HUMAN|HGNC=5006|UniProtKB=P04035	3-hydroxy-3-methylglutaryl-coenzyme A reductase	ISS	P00347	SPACC	PTHR10572:SF2	3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE
P00021	FGF signaling pathway	P00632	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P04373	5HT1 type receptor mediated signaling pathway	P04407	K+ channel	MOUSE|MGI=MGI=3521816|UniProtKB=Q3LS21	Potassium channel subfamily K member 9	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00052	TGF-beta signaling pathway	P01275	P38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P06664	Gonadotropin-releasing hormone receptor pathway	P06786	ERK1/2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	RCA	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02784	Tyrosine biosynthesis	P03212	Chorismate mutase	STRCO|Gene=CAB52826|UniProtKB=Q9S238	Putative chorismate mutase	ISS			PTHR21164:SF0	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00551	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04566	Stat 1/3	MACMU|Ensembl=ENSMMUG00000010707|UniProtKB=F7G8G5	Signal transducer and activator of transcription	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	BOVIN|Ensembl=ENSBTAG00000012687|UniProtKB=F1MV64	Tyrosine-protein kinase receptor	ISS	11182407	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	HUMAN|HGNC=1961|UniProtKB=P11230	Acetylcholine receptor subunit beta	IC	22213672	PubMed	PTHR18945:SF477	ACETYLCHOLINE RECEPTOR SUBUNIT BETA
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	RAT|RGD=621005|UniProtKB=Q08849	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2742|UniProtKB=P23385	Metabotropic glutamate receptor 1	IDA			PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00049	Parkinson disease	P01230	Src kinase	BOVIN|Ensembl=ENSBTAG00000012695|UniProtKB=Q3ZCM0	Tyrosine-protein kinase	ISS	1505025	PubMed	PTHR24418:SF39	TYROSINE-PROTEIN KINASE LCK
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000009766|UniProtKB=F6TFL4	Uncharacterized protein	ISS	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00141	Membrane metalloprotease	MOUSE|MGI=MGI=109320|UniProtKB=O54732	Matrix metalloproteinase-15	TAS	12834808	PubMed	PTHR10201:SF25	MATRIX METALLOPROTEINASE-15
P00038	JAK/STAT signaling pathway	P01027	STAT	MOUSE|MGI=MGI=103036|UniProtKB=P42230	Signal transducer and activator of transcription 5A	ISS	14662325	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00010	B cell activation	P00379	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00049	Parkinson disease	P01211	ERK	PANTR|Ensembl=ENSPTRG00000008867|UniProtKB=H2QCF3	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00029	Huntington disease	P00778	NMDA receptor	CAEBR|Gene=CBG02401|UniProtKB=A8WUE7	Protein CBR-NMR-1	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	MONDO|Ensembl=ENSMODG00000017515|UniProtKB=F7F0J5	Uncharacterized protein	ISS	10082669	PubMed	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P02756	N-acetylglucosamine metabolism	P03040	N-acetylneuraminate lyase	RAT|RGD=1549702|UniProtKB=Q66H59	N-acetylneuraminate lyase	ISS			PTHR12128:SF21	N-ACETYLNEURAMINATE LYASE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	3045562	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	IC	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00035	Interferon-gamma signaling pathway	P00960	PTP	PANTR|Ensembl=ENSPTRG00000042397|UniProtKB=H2RIH8	Tyrosine-protein phosphatase non-receptor type	ISS	14525967	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	PANTR|Ensembl=ENSPTRG00000012555|UniProtKB=H2QIU9	Serine/threonine-protein kinase receptor	ISS	9395284	PubMed	PTHR23255:SF69	ACTIVIN RECEPTOR TYPE-1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	TAS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00029	Huntington disease	P00780	Microtubule	STRPU|EnsemblGenome=SPU_007425|UniProtKB=W4XVG9	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00539	14-3-3	ORNAN|Ensembl=ENSOANG00000007305|UniProtKB=F6XW91	Uncharacterized protein	ISS	92283271	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	YEAST|SGD=S000000201|UniProtKB=P24583	Protein kinase C-like 1	IC	90322419	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IGI	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00021	FGF signaling pathway	P00627	ERK1-2	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05912	Dopamine receptor mediated signaling pathway	P05950	DARPP-32	MACMU|Ensembl=ENSMMUG00000001405|UniProtKB=F7CTZ0	Protein phosphatase 1 regulatory subunit 1B isoform 1	ISS	3339428	PubMed	PTHR15417:SF2	PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 1B
P04397	p53 pathway by glucose deprivation	P04639	AMPK	RAT|RGD=620905|UniProtKB=Q9QZH4	5'-AMP-activated protein kinase subunit beta-2	ISS			PTHR10343:SF45	5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	BOVIN|Ensembl=ENSBTAG00000033153|UniProtKB=F1MG21	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00048	PI3 kinase pathway	G01546	Cyclin d	MACMU|Ensembl=ENSMMUG00000002368|UniProtKB=F7BZY1	Uncharacterized protein	ISS	93330551	PubMed	PTHR10177:SF67	G1/S-SPECIFIC CYCLIN-D1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ORYSJ|Gene=Os01g0866100|UniProtKB=P0C540	Actin-7	ISS	11889126	PubMed	PTHR11937:SF205	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05731	GABA-B receptor II signaling	P05755	Gbeta	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	BOVIN|Ensembl=ENSBTAG00000021151|UniProtKB=Q27991	Myosin-10	ISS	89264452	PubMed	PTHR13140:SF328	MYOSIN-10
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00402	Jnk	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00628	JNK1-3	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01465	Ggamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00010	B cell activation	P00376	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IDA	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	BOVIN|Ensembl=ENSBTAG00000009277|UniProtKB=A7MBG6	RGS17 protein	ISS	8756726	PubMed	PTHR10845:SF196	REGULATOR OF G-PROTEIN SIGNALING 17
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	RAT|RGD=628852|UniProtKB=Q02294	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	15079861	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00018	EGF receptor signaling pathway	P00551	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IGI	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DANRE|ZFIN=ZDB-GENE-000329-3|UniProtKB=Q7ZVF9	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00036	Interleukin signaling pathway	P00965	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IC	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00318	PKCs	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00012	Cadherin signaling pathway	P00474	Wnt	DANRE|ZFIN=ZDB-GENE-980526-332|UniProtKB=P51028	Protein Wnt-8a	IDA	8717036	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CAEEL|WormBase=WBGene00000063|UniProtKB=P0DM41	Actin-1	IDA	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	IDA	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	12812976	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	RAT|RGD=3693|UniProtKB=Q01818	Chromaffin granule amine transporter	ISS	92370677	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	YEAST|SGD=S000006153|UniProtKB=P32867	Protein SSO1	IC			PTHR19957:SF41	SYNTAXIN-1A
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04397	p53 pathway by glucose deprivation	P04639	AMPK	PANTR|Ensembl=ENSPTRG00000001218|UniProtKB=H2PZU8	Protein kinase, AMP-activated, beta 2 non-catalytic subunit	ISS			PTHR10343:SF45	5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IDA	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00048	PI3 kinase pathway	P01188	Gbetagamma	IXOSC|EnsemblGenome=ISCW009711|UniProtKB=B7Q3T6	THO complex subunit, putative	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00046	Oxidative stress response	P01133	Max	DANRE|ZFIN=ZDB-GENE-990415-152|UniProtKB=P52161	Protein max	TAS	11274345	PubMed	PTHR10328:SF3	PROTEIN MAX
P00006	Apoptosis signaling pathway	P00318	PKCs	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	PANTR|Ensembl=ENSPTRG00000015856|UniProtKB=H2QP51	Regulator of G-protein signaling 12	ISS	8756726	PubMed	PTHR10845:SF149	REGULATOR OF G-PROTEIN SIGNALING 12
P00048	PI3 kinase pathway	P01199	Galpha	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IC	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02738	De novo purine biosynthesis	P02907	dADP kinase	CANLF|Ensembl=ENSCAFG00000015856|UniProtKB=J9P3S5	Nucleoside diphosphate kinase	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P00001	Adrenaline and noradrenaline biosynthesis	P00066	DOPA decarb.	ORYSJ|EnsemblGenome=OS10G0380800|UniProtKB=Q7G6M2	Os10g0380800 protein	ISS			PTHR11999:SF141	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01188	Gbetagamma	HUMAN|HGNC=4401|UniProtKB=O14775	Guanine nucleotide-binding protein subunit beta-5	IC	11313908	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	MOUSE|MGI=MGI=106684|UniProtKB=Q8R090	Chromaffin granule amine transporter	ISS	92370677	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00011	Blood coagulation	P00448	vWF	CANLF|Gene=VWF|UniProtKB=Q28295	von Willebrand factor	ISS	11583304	PubMed	PTHR11339:SF361	VON WILLEBRAND FACTOR-RELATED
P00005	Angiogenesis	P00237	FRP	HUMAN|HGNC=4038|UniProtKB=Q9UP38	Frizzled-1	IC	12549854	PubMed	PTHR11309:SF81	FRIZZLED-1
P00018	EGF receptor signaling pathway	P00565	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00049	Parkinson disease	P01242	Casein kinase I	CANLF|Ensembl=ENSCAFG00000000557|UniProtKB=J9P9W3	Uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF151	CASEIN KINASE I ISOFORM GAMMA-3
P00052	TGF-beta signaling pathway	P01286	TGFbeta	XENTR|Xenbase=XB-GENE-479191|UniProtKB=F7CB21	Metalloendopeptidase	ISS	9759503	PubMed	PTHR43978:SF3	BONE MORPHOGENETIC PROTEIN 1
P00006	Apoptosis signaling pathway	P00274	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_127489|UniProtKB=C3XYC6	Putative uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	CAEEL|WormBase=WBGene00016652|UniProtKB=O01804	Aspartate aminotransferase	ISS			PTHR11879:SF4	ASPARTATE AMINOTRANSFERASE
P00021	FGF signaling pathway	P00644	p38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04378	Beta2 adrenergic receptor signaling pathway	P04441	ER-type Ca2+ channel	HUMAN|HGNC=10484|UniProtKB=Q92736	Ryanodine receptor 2	ISS	8930069	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PANTR|Ensembl=ENSPTRG00000006890|UniProtKB=H2Q943	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P02749	Leucine biosynthesis	P03001	3-Isopropylmalate dehydrogenase	YARLI|Gene=YALI0C00407g|UniProtKB=P18120	3-isopropylmalate dehydrogenase	ISS			PTHR42979:SF1	3-ISOPROPYLMALATE DEHYDROGENASE
P00018	EGF receptor signaling pathway	P00562	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IGI	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00029	Huntington disease	P00777	CBP	CAEEL|WormBase=WBGene00010545|UniProtKB=G5EBG3	CBP/p300 homolog	IDA	10664585	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	DANRE|ZFIN=ZDB-GENE-051202-2|UniProtKB=Q6ZM67	Uncharacterized protein	ISS	14698601	PubMed	PTHR44391:SF3	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00951	Jnk	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00018	EGF receptor signaling pathway	P00552	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P05730	Endogenous cannabinoid signaling	P05746	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04392	P53 pathway feedback loops 1	G04684	Pirh-2	HUMAN|HGNC=17479|UniProtKB=Q96PM5	RING finger and CHY zinc finger domain-containing protein 1	ISS	607680	OMIM	PTHR21319:SF20	RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00053	T cell activation	P01334	WASP	CANLF|Ensembl=ENSCAFG00000015519|UniProtKB=F6X487	Uncharacterized protein	ISS	10544204	PubMed	PTHR23202:SF35	WISKOTT-ALDRICH SYNDROME PROTEIN
P00018	EGF receptor signaling pathway	P00539	14-3-3	NEUCR|EnsemblGenome=EFNCRG00000002359|UniProtKB=Q7RVK6	14-3-3 family protein 7	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	RCA	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	BOVIN|Ensembl=ENSBTAG00000006495|UniProtKB=P11017	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00053	T cell activation	P01314	nck	MACMU|Ensembl=ENSMMUG00000007389|UniProtKB=F7E0A3	Cytoplasmic protein NCK1 isoform 1	ISS	12874226	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P00021	FGF signaling pathway	P00628	JNK1-3	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	NAS			PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04398	p53 pathway feedback loops 2	P04665	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01407	Erk	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01154	Ras	CAEEL|WormBase=WBGene00004310|UniProtKB=G5EBK8	GTP binding protein	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P04397	p53 pathway by glucose deprivation	P04641	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06856	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	RCA	12748278	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00036	Interleukin signaling pathway	P00965	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IC	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	RAT|RGD=1309574|UniProtKB=D3ZFS0	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF84	PROTEIN WNT-9B
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	XENTR|Xenbase=XB-GENE-481916|UniProtKB=F6YF14	Presenilin	ISS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00054	Toll receptor signaling pathway	P01352	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	MOUSE|MGI=MGI=88296|UniProtKB=O55017	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	8386525	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01428	Frizzled	MOUSE|MGI=MGI=108570|UniProtKB=Q61090	Frizzled-7	IDA	11212302	PubMed	PTHR11309:SF31	FRIZZLED-7
P05913	Enkephalin release	P05972	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=98327|UniProtKB=P30873	Somatostatin receptor type 1	IDA	12441358	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P02757	O-antigen biosynthesis	P03044	Phosphoglucosamine mutase	FUSNN|EnsemblGenome=FN0366|UniProtKB=Q8R6A7	Phosphoglucosamine mutase	ISS			PTHR42946:SF1	PHOSPHOGLUCOSAMINE MUTASE FAMILY PROTEIN
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	IPI	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MONDO|Ensembl=ENSMODG00000018065|UniProtKB=F7G485	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00013	Cell cycle	P00480	Proteasome	PANTR|Ensembl=ENSPTRG00000013893|UniProtKB=H2PZY5	Uncharacterized protein	ISS	13645506	gi	PTHR10223:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4
P00005	Angiogenesis	P00206	Wnt	BRAFL|Gene=BRAFLDRAFT_113720|UniProtKB=C3YYJ8	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02913	Thymidylate synthase	HUMAN|HGNC=12441|UniProtKB=P04818	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P04393	Ras Pathway	P04553	PAK	MONDO|Ensembl=ENSMODG00000018459|UniProtKB=F7CU42	Uncharacterized protein	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00038	JAK/STAT signaling pathway	P01031	PIAS	XENTR|Xenbase=XB-GENE-486558|UniProtKB=F6YUL3	Uncharacterized protein (Fragment)	ISS	8682149	PubMed	PTHR10782:SF11	E3 SUMO-PROTEIN LIGASE PIAS1
P05918	p38 MAPK pathway	P06033	TAB2	HUMAN|HGNC=17075|UniProtKB=Q9NYJ8	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2	ISS			PTHR10351:SF27	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 2
P00049	Parkinson disease	P01212	p38 MAPK	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	NAS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01457	GBeta	IXOSC|EnsemblGenome=ISCW009711|UniProtKB=B7Q3T6	THO complex subunit, putative	ISS	9754712	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	HUMAN|HGNC=1736|UniProtKB=P60953	Cell division control protein 42 homolog	IDA	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CANLF|Ensembl=ENSCAFG00000012181|UniProtKB=F2Z4N7	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00021	FGF signaling pathway	P00640	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IGI	12660731	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00049	Parkinson disease	P01219	SAPK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00052	TGF-beta signaling pathway	P01275	P38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00801	Fos protein	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	TAS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01169	Vav	MACMU|Ensembl=ENSMMUG00000019714|UniProtKB=F7H0I2	Uncharacterized protein	ISS	14623913	PubMed	PTHR22826:SF97	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3
P00005	Angiogenesis	P00203	Erk	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04376	5HT4 type receptor mediated signaling pathway	P04427	5HT4 Receptor	BOVIN|Ensembl=ENSBTAG00000010837|UniProtKB=F1N3N9	Uncharacterized protein	ISS	12898568	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P05731	GABA-B receptor II signaling	P05760	AC	BOVIN|Ensembl=ENSBTAG00000018777|UniProtKB=E1BHU9	Uncharacterized protein	ISS	1409703	PubMed	PTHR11920:SF332	ADENYLATE CYCLASE TYPE 5
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	BACSU|EnsemblGenome=BSU23800|UniProtKB=P54552	Pyrroline-5-carboxylate reductase 2	ISS			PTHR11645:SF0	PYRROLINE-5-CARBOXYLATE REDUCTASE
P00029	Huntington disease	P00774	Dynein complex	SCHMA|EnsemblGenome=Smp_095520|UniProtKB=G4V853	Putative dynein light chain	IPI	9454836	PubMed	PTHR11886:SF62	DYNEIN, LIGHT CHAIN, LC8-TYPE 2
P00056	VEGF signaling pathway	P01413	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	ISS	7565716	PubMed	PTHR10048:SF14	PI-3 KINASE
P00057	Wnt signaling pathway	P01443	Phospholipase C	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04547	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MACMU|Ensembl=ENSMMUG00000021442|UniProtKB=F7EAQ8	Muscarinic acetylcholine receptor	ISS	11166329	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	MACMU|Ensembl=ENSMMUG00000014817|UniProtKB=F6VXD8	Uncharacterized protein	ISS	193001	OMIM	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	XENTR|Xenbase=XB-GENE-990010|UniProtKB=F6WX69	Uncharacterized protein (Fragment)	ISS	95224005	PubMed	PTHR18945:SF60	ACETYLCHOLINE RECEPTOR SUBUNIT GAMMA
P00010	B cell activation	P00373	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	CANLF|Ensembl=ENSCAFG00000015873|UniProtKB=F6XU71	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00011	Blood coagulation	P00438	Bradykinin	RAT|RGD=2980|UniProtKB=P08934	Kininogen-1	ISS	6981138	gi	PTHR13814:SF12	KININOGEN-1
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01275	P38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	12810719	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00034	Integrin signalling pathway	P00931	Integrin beta	MACMU|Ensembl=ENSMMUG00000003289|UniProtKB=F7FG54	Integrin beta	ISS	5805343	gi	PTHR10082:SF25	INTEGRIN BETA-3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	CAEBR|Gene=CBG14305|UniProtKB=A8XJQ6	cAMP-dependent protein kinase, catalytic subunit-like	ISS	1319556	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	PANTR|Ensembl=ENSPTRG00000003795|UniProtKB=H2Q3X5	Muscarinic acetylcholine receptor	ISS	11166329	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00036	Interleukin signaling pathway	P00983	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04557	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00012	Cadherin signaling pathway	P00462	Casein kinase II	HUMAN|HGNC=2458|UniProtKB=Q8NEV1	Casein kinase II subunit alpha 3	ISS	10806215	PubMed	PTHR24054:SF16	CASEIN KINASE II SUBUNIT ALPHA-RELATED
P00059	p53 pathway	P01486	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01411	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	IDA	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	PANTR|Ensembl=ENSPTRG00000002086|UniProtKB=H2Q1A9	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00034	Integrin signalling pathway	P00944	Actin	MOUSE|MGI=MGI=87904|UniProtKB=P60710	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00029	Huntington disease	P00772	FIP-2	MACMU|Ensembl=ENSMMUG00000005601|UniProtKB=Q861Q8	Optineurin	TAS			PTHR31553:SF2	OPTINEURIN
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	MACMU|Ensembl=ENSMMUG00000005748|UniProtKB=F6TWH6	Transcription initiation factor TFIID subunit 12	ISS			PTHR12264:SF21	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12
P00005	Angiogenesis	P00219	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	BOVIN|Gene=ADRBK2|UniProtKB=P26818	Beta-adrenergic receptor kinase 2	IDA	10852916	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	BOVIN|Ensembl=ENSBTAG00000006159|UniProtKB=E1BNE9	G protein-activated inward rectifier potassium channel 1	ISS	2433589	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	IDA	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	TAS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00046	Oxidative stress response	P01129	JNK1/2	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00572	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00019	Endothelin signaling pathway	P00566	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	RAT|RGD=3250|UniProtKB=P35465	Serine/threonine-protein kinase PAK 1	ISS	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00005	Angiogenesis	P00182	p38MAPK	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IGI	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	HUMAN|HGNC=144|UniProtKB=P63261	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01435	SWI/SNF	ORYSJ|EnsemblGenome=OS05G0150300|UniProtKB=Q5WN07	Os05g0150300 protein	IDA	11532957	PubMed	PTHR10799:SF879	CHROMATIN-REMODELING COMPLEX ATPASE CHAIN ISWI
P04393	Ras Pathway	P04542	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01242	Casein kinase I	YEAST|SGD=S000000925|UniProtKB=P39962	Casein kinase I homolog 3	IDA	11437445	PubMed	PTHR11909:SF155	GILGAMESH, ISOFORM L
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	RAT|RGD=2520|UniProtKB=P61169	D(2) dopamine receptor	IDA	11248120	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	CANLF|Ensembl=ENSCAFG00000007780|UniProtKB=F1PZH9	Uncharacterized protein	ISS	1608964	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00015	Circadian clock system	G01501	cry	HUMAN|HGNC=2385|UniProtKB=Q49AN0	Cryptochrome-2	IDA	14507900	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01200	SHIP	HUMAN|HGNC=6080|UniProtKB=O15357	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	IC	9824312	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	CAEEL|WormBase=WBGene00000366|UniProtKB=P34545	Protein cbp-1	TAS	10823891	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00057	Wnt signaling pathway	P01471	alpha-catenin	ANOGA|EnsemblGenome=AGAP003424|UniProtKB=Q7QDI9	AGAP003424-PA	ISS	9362521	PubMed	PTHR18914:SF9	CATENIN ALPHA
P00057	Wnt signaling pathway	P01465	Ggamma	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00797	p53	BOVIN|Ensembl=ENSBTAG00000005812|UniProtKB=G3X6J7	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00010	B cell activation	P00375	Calmodulin	CANLF|Ensembl=ENSCAFG00000016335|UniProtKB=J9NXY2	Uncharacterized protein	ISS	9753452	PubMed	PTHR23050:SF322	SUBFAMILY NOT NAMED
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00322	Cytochrome C	XENTR|Xenbase=XB-GENE-5931974|UniProtKB=Q640U4	Cytochrome c, somatic	ISS	11836241	PubMed	PTHR11961:SF12	CYTOCHROME C
P04393	Ras Pathway	P04570	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	IC	8838325	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	ANOGA|EnsemblGenome=AGAP010750|UniProtKB=Q7PMK5	AGAP010750-PA	ISS	15858232	PubMed	PTHR13715:SF79	RYANODINE RECEPTOR
P04398	p53 pathway feedback loops 2	P04658	PTEN	DANRE|ZFIN=ZDB-GENE-030131-3776|UniProtKB=E7FC59	Uncharacterized protein	ISS			PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00007	Axon guidance mediated by semaphorins	P00339	CRMP	CANLF|Ensembl=ENSCAFG00000010962|UniProtKB=F1Q088	Uncharacterized protein	ISS			PTHR11647:SF55	DIHYDROPYRIMIDINASE-RELATED PROTEIN 4
P02771	Pyrimidine Metabolism	P03128	Dihydrouracil Dehydrogenase	RAT|RGD=621218|UniProtKB=O89000	Dihydropyrimidine dehydrogenase [NADP(+)]	ISS	9819714	PubMed	PTHR43073:SF2	DIHYDROPYRIMIDINE DEHYDROGENASE  NADP +
P00004	Alzheimer disease-presenilin pathway	P00118	E-cadherin	RAT|RGD=69279|UniProtKB=Q9R0T4	Cadherin-1	IDA	12834808	PubMed	PTHR24027:SF319	CADHERIN-1
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	DANRE|ZFIN=ZDB-GENE-040426-877|UniProtKB=F1Q6Z7	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	IGI	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02771	Pyrimidine Metabolism	P03127	Beta-Ureidopropionase	ARATH|TAIR=AT5G64370|UniProtKB=Q8H183	Beta-ureidopropionase	IEA	15237683	gi	PTHR43674:SF2	BETA-UREIDOPROPIONASE
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00029	Huntington disease	P00780	Microtubule	PHYPA|Gene=PHYPADRAFT_165677|UniProtKB=Q6TYR3	Beta-tubulin 5	ISS	12932731	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	PANTR|Ensembl=ENSPTRG00000000271|UniProtKB=Q5IS65	5-hydroxytryptamine receptor 6	ISS	12441358	PubMed	PTHR24247:SF114	5-HYDROXYTRYPTAMINE RECEPTOR 6
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00005	Angiogenesis	P00242	TCF	HUMAN|HGNC=11641|UniProtKB=Q9NQB0	Transcription factor 7-like 2	IDA	12176738	PubMed	PTHR10373:SF32	TRANSCRIPTION FACTOR 7-LIKE 2
P00048	PI3 kinase pathway	P01177	P110ACT	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PHYPA|Gene=PHYPADRAFT_226658|UniProtKB=A9TYG3	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00053	T cell activation	P01300	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00047	PDGF signaling pathway	P01167	Ets	MACMU|Ensembl=ENSMMUG00000020706|UniProtKB=F6PU72	Uncharacterized protein	ISS	9157999	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	IDA	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00019	Endothelin signaling pathway	P00568	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	HUMAN|HGNC=4580|UniProtKB=Q13002	Glutamate receptor ionotropic, kainate 2	ISS	12778120	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00021	FGF signaling pathway	P00632	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00273	p53	PANTR|Ensembl=ENSPTRG00000008703|UniProtKB=H2QC53	Cellular tumor antigen p53	ISS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P05913	Enkephalin release	P05972	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00017	DNA replication	P00527	Histones	MOUSE|MGI=MGI=1097686|UniProtKB=P84244	Histone H3.3	IDA	12413958	PubMed	PTHR11426:SF166	HISTONE H3.3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PHANO|EnsemblGenome=SNOG_01139|UniProtKB=H2KNE6	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MACMU|Ensembl=ENSMMUG00000002037|UniProtKB=F6WYF2	Uncharacterized protein	ISS	3009463	PubMed	PTHR10201:SF151	INTERSTITIAL COLLAGENASE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00005	Angiogenesis	P00223	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04392	P53 pathway feedback loops 1	P04539	p53	BOVIN|Ensembl=ENSBTAG00000001069|UniProtKB=P67939	Cellular tumor antigen p53	TAS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00019	Endothelin signaling pathway	P00588	ET1-4	PANTR|Ensembl=ENSPTRG00000013684|UniProtKB=H2R2X8	Uncharacterized protein	ISS	10884419	PubMed	PTHR13874:SF11	ENDOTHELIN-3
P04398	p53 pathway feedback loops 2	P04668	p53	BOVIN|Ensembl=ENSBTAG00000001069|UniProtKB=P67939	Cellular tumor antigen p53	TAS	14744434	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000010612|UniProtKB=E1C6T4	Serine/threonine-protein kinase	ISS	12676944	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	IDA	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04393	Ras Pathway	P04547	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	87226391	PubMed	PTHR24070:SF385	GTPASE HRAS
P00035	Interferon-gamma signaling pathway	P00956	SOCS	BOVIN|Ensembl=ENSBTAG00000008441|UniProtKB=Q9BEG9	Suppressor of cytokine signaling 3	ISS	15032587	PubMed	PTHR44534:SF3	SUPPRESSOR OF CYTOKINE SIGNALING 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	RAT|RGD=621533|UniProtKB=P12389	Neuronal acetylcholine receptor subunit alpha-2	IC	85270494	PubMed	PTHR18945:SF757	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000019262|UniProtKB=F6SQ28	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00048	PI3 kinase pathway	P01205	NOS	PANTR|Ensembl=ENSPTRG00000019868|UniProtKB=H2QVM2	Nitric oxide synthase	ISS	9837777	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00056	VEGF signaling pathway	P01411	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	TAS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00047	PDGF signaling pathway	P01171	PLCgamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P06959	CCKR signaling map	G06981	E-cadherin	HUMAN|HGNC=1748|UniProtKB=P12830	Cadherin-1	RCA	18515095	PubMed	PTHR24027:SF319	CADHERIN-1
P04397	p53 pathway by glucose deprivation	P04642	Rheb	TAKRU|Ensembl=ENSTRUG00000004902|UniProtKB=H2SH25	Uncharacterized protein	ISS			PTHR24070:SF264	GTP-BINDING PROTEIN RHEB
P00034	Integrin signalling pathway	P00916	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00052	TGF-beta signaling pathway	P01275	P38	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	TAS	4506785	gi	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00048	PI3 kinase pathway	P01179	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00007	Axon guidance mediated by semaphorins	P00341	Rho	HUMAN|HGNC=667|UniProtKB=P61586	Transforming protein RhoA	ISS	12169092	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P05916	Opioid prodynorphin pathway	P06001	AC	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00857	IkappaB	RAT|RGD=3171|UniProtKB=Q63746	NF-kappa-B inhibitor alpha	ISS	12637573	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	HUMAN|HGNC=2211|UniProtKB=P12109	Collagen alpha-1(VI) chain	ISS	10778855	PubMed	PTHR44172:SF3	COLLAGEN ALPHA-1 VI  CHAIN
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00045	Notch signaling pathway	P01099	Notch	MOUSE|MGI=MGI=97364|UniProtKB=O35516	Neurogenic locus notch homolog protein 2	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00018	EGF receptor signaling pathway	P00558	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IGI	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00049	Parkinson disease	P01219	SAPK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	15528206	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00217	STAT3	RAT|RGD=3772|UniProtKB=P52631	Signal transducer and activator of transcription 3	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00023	General transcription regulation	P00670	TBP	MOUSE|MGI=MGI=1339946|UniProtKB=P62340	TATA box-binding protein-like protein 1	ISS	600075	OMIM	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	CHICK|Ensembl=ENSGALG00000011905|UniProtKB=F1NHT7	Uncharacterized protein	TAS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MONDO|Ensembl=ENSMODG00000004799|UniProtKB=F6VM87	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00034	Integrin signalling pathway	P00944	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g234494|UniProtKB=A7RU31	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	TAS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	RAT|RGD=1303282|UniProtKB=Q6MG89	Notch homolog 4, [Drosophila]	ISS	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00019	Endothelin signaling pathway	P00572	MEK	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00047	PDGF signaling pathway	P01154	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01153	GSK3	ARATH|TAIR=AT4G00720|UniProtKB=Q96287	Shaggy-related protein kinase theta	ISS	12615961	PubMed	PTHR24057:SF19	SHAGGY-RELATED PROTEIN KINASE BETA-RELATED
P00046	Oxidative stress response	P01138	MKK4	BOVIN|Ensembl=ENSBTAG00000012103|UniProtKB=A5PJP8	MAP2K4 protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00057	Wnt signaling pathway	P01446	Calcineurin	NEUCR|EnsemblGenome=EFNCRG00000003474|UniProtKB=Q05681	Serine/threonine-protein phosphatase 2B catalytic subunit	IDA	7532676	PubMed	PTHR11668:SF118	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED
P00034	Integrin signalling pathway	P00924	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IPI	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P02761	Pantothenate biosynthesis	P03066	Aspartate decarboxylase	GLOVI|EnsemblGenome=BAC92169|UniProtKB=Q7NDK7	Aspartate 1-decarboxylase 2	ISS			PTHR21012:SF0	ASPARTATE 1-DECARBOXYLASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06798	PKCe/theta	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00057	Wnt signaling pathway	P01443	Phospholipase C	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00018	EGF receptor signaling pathway	P00557	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	CAEBR|Gene=CBG_05938|UniProtKB=H8WGV2	Protein CBR-ITR-1, isoform a	ISS	1849282	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P04393	Ras Pathway	P04555	PDK	CANLF|Ensembl=ENSCAFG00000019358|UniProtKB=F1Q2Y3	Uncharacterized protein	ISS	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	EMENI|EnsemblGenome=CADANIAG00007315|UniProtKB=P20359	Actin, gamma	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00629	PP2A	ARATH|TAIR=AT3G26020|UniProtKB=Q9LU89	Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' eta isoform	ISS			PTHR10257:SF46	SERINE/THREONINE PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B' DELTA ISOFORM-RELATED
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000010989|UniProtKB=P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00046	Oxidative stress response	P01125	Stat1	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	TAS	14984365	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	IDA	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00056	VEGF signaling pathway	P01408	Akt/PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00916	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P02754	Methylcitrate cycle	P03028	Aconitase	CHICK|Gene_ORFName=RCJMB04_5d21|UniProtKB=Q5ZLQ4	Iron-responsive element-binding protein 2	ISS			PTHR11670:SF31	IRON-RESPONSIVE ELEMENT-BINDING PROTEIN 2
P00021	FGF signaling pathway	P00632	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00029	Huntington disease	P00807	Actin	BRAFL|Gene=BRAFLDRAFT_58093|UniProtKB=C3Z4K3	Putative uncharacterized protein	IDA	11889126	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000005917|UniProtKB=F6QM53	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00021	FGF signaling pathway	P00633	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	TAS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04558	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IDA	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00053	T cell activation	P01318	PKC-theta	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IGI	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P04371	5-Hydroxytryptamine biosynthesis	P04400	Aromatic L-amino acid decarboxylase	CAEEL|WormBase=WBGene00000239|UniProtKB=O45137	Biogenic Amine Synthesis related	ISS	90339966	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MACMU|Ensembl=ENSMMUG00000016675|UniProtKB=F6VTB5	Uncharacterized protein	ISS	11319238	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00047	PDGF signaling pathway	P01171	PLCgamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	CAEEL|WormBase=WBGene00004310|UniProtKB=G5EBK8	GTP binding protein	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00029	Huntington disease	P00807	Actin	GIAIC|EnsemblGenome=GL50803_40817|UniProtKB=A8BV70	Actin related protein	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00769	N-Wasp	HUMAN|HGNC=12735|UniProtKB=O00401	Neural Wiskott-Aldrich syndrome protein	TAS	12932731	PubMed	PTHR23202:SF39	NEURAL WISKOTT-ALDRICH SYNDROME PROTEIN
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	MACMU|Ensembl=ENSMMUG00000020441|UniProtKB=F6W7N2	Uncharacterized protein	ISS			PTHR11482:SF42	ORNITHINE DECARBOXYLASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MOUSE|MGI=MGI=87902|UniProtKB=P68134	Actin, alpha skeletal muscle	ISS	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IDA	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00048	PI3 kinase pathway	P01188	Gbetagamma	HUMAN|HGNC=4411|UniProtKB=P63211	Guanine nucleotide-binding protein G(T) subunit gamma-T1	IC	3100519	PubMed	PTHR13809:SF26	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT GAMMA-T1
P00054	Toll receptor signaling pathway	P01375	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00010	B cell activation	P00371	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	TAS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	BOVIN|Ensembl=ENSBTAG00000021151|UniProtKB=Q27991	Myosin-10	IC	89264452	PubMed	PTHR13140:SF328	MYOSIN-10
P00059	p53 pathway	P01486	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00398	IP3R	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00019	Endothelin signaling pathway	P00568	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	10395542	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00060	Ubiquitin proteasome pathway	P01491	E2	DICDI|dictyBase=DDB_G0274313|UniProtKB=Q86IZ3	Ubiquitin-conjugating enzyme E2 pex4	ISS			PTHR43902:SF1	UBIQUITIN-CONJUGATING ENZYME E2-21 KDA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	IXOSC|EnsemblGenome=ISCW009711|UniProtKB=B7Q3T6	THO complex subunit, putative	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	RAT|RGD=2323655|UniProtKB=D4A7M6	Protein LOC100359539	ISS			PTHR23409:SF20	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00005	Angiogenesis	P00254	GTPase	CANLF|Ensembl=ENSCAFG00000018512|UniProtKB=E2RLH2	Uncharacterized protein	ISS	10556059	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00029	Huntington disease	P00775	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05915	Opioid proenkephalin pathway	P05987	peptide F	DANRE|ZFIN=ZDB-GENE-030729-3|UniProtKB=F1QTD1	Uncharacterized protein (Fragment)	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00020	FAS signaling pathway	P00616	Nuclear Lamin	XENTR|Xenbase=XB-GENE-489658|UniProtKB=F7EGF8	Uncharacterized protein	ISS	11165516	PubMed	PTHR23239:SF157	LAMIN-B1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MACMU|Ensembl=ENSMMUG00000020021|UniProtKB=F7GIZ6	Uncharacterized protein	ISS	10839363	PubMed	PTHR19957:SF104	SYNTAXIN-6
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	ARATH|TAIR=AT2G32400|UniProtKB=Q9SDQ4	Glutamate receptor 3.7	ISS	12871085	PubMed	PTHR43891:SF15	GLUTAMATE RECEPTOR 3.7
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00010	B cell activation	P00384	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	STRCO|Gene=CAB89022|UniProtKB=Q9KZC8	Uncharacterized protein	ISS			PTHR43383:SF1	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04661	PI3K	ARATH|TAIR=AT1G60490|UniProtKB=P42339	Phosphatidylinositol 3-kinase VPS34	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00029	Huntington disease	P00799	JNK-2	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00047	PDGF signaling pathway	P01151	PKB	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00014	Cholesterol biosynthesis	P00496	Diphosphomevalonate decarboxylase	RAT|RGD=621292|UniProtKB=Q62967	Diphosphomevalonate decarboxylase	ISS	4505289	gi	PTHR10977:SF3	DIPHOSPHOMEVALONATE DECARBOXYLASE
P00047	PDGF signaling pathway	P01154	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00029	Huntington disease	P00787	MAPKK4	MOUSE|MGI=MGI=1346869|UniProtKB=P47809	Dual specificity mitogen-activated protein kinase kinase 4	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00006	Apoptosis signaling pathway	P00318	PKCs	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	RAT|RGD=3921|UniProtKB=P45352	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P04398	p53 pathway feedback loops 2	P04663	Mdm2	CANLF|Ensembl=ENSCAFG00000009669|UniProtKB=E2RDT3	Uncharacterized protein	ISS			PTHR13844:SF20	PROTEIN MDM4
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	RCA	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01407	Erk	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00012	Cadherin signaling pathway	P00463	betacatenin	HUMAN|HGNC=2514|UniProtKB=P35222	Catenin beta-1	IDA	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00047	PDGF signaling pathway	P01145	c-fos	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	HUMAN|HGNC=9857|UniProtKB=P61224	Ras-related protein Rap-1b	IDA	8576107	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	PANTR|Gene=CXCR1|UniProtKB=P55920	C-X-C chemokine receptor type 1	ISS	9110929	PubMed	PTHR10489:SF916	C-X-C CHEMOKINE RECEPTOR TYPE 1
P00004	Alzheimer disease-presenilin pathway	P00128	Erb-B4	MACMU|Ensembl=ENSMMUG00000001674|UniProtKB=F7G3H1	Receptor protein-tyrosine kinase	ISS	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00046	Oxidative stress response	P01129	JNK1/2	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00053	T cell activation	P01312	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00029	Huntington disease	P00796	Kainate receptor	BOVIN|Ensembl=ENSBTAG00000011723|UniProtKB=E1BKL6	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P05913	Enkephalin release	P05974	G-Protein (i)	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_94959|UniProtKB=C3XYC4	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9062|UniProtKB=Q9BRC7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	12860966	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00049	Parkinson disease	P01242	Casein kinase I	RAT|RGD=621404|UniProtKB=Q62761	Casein kinase I isoform gamma-1	ISS	11437445	PubMed	PTHR11909:SF156	CASEIN KINASE I ISOFORM GAMMA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	TAS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01455	Smad4	RAT|RGD=3033|UniProtKB=O70437	Mothers against decapentaplegic homolog 4	IDA	9395284	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P00059	p53 pathway	P01486	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01417	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00019	Endothelin signaling pathway	P00568	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-823|UniProtKB=Q6PH57	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00005	Angiogenesis	P00252	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	11384839	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00559	MEK1-2	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IGI	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00018	EGF receptor signaling pathway	P00539	14-3-3	ORNAN|Ensembl=ENSOANG00000007305|UniProtKB=F6XW91	Uncharacterized protein	ISS	12615066	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00009	Axon guidance mediated by netrin	P00359	NFAT	MOUSE|MGI=MGI=1920431|UniProtKB=Q8K120	Nuclear factor of activated T-cells, cytoplasmic 4	IDA	12787506	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00012	Cadherin signaling pathway	P00470	F-actin	MACMU|Ensembl=ENSMMUG00000007027|UniProtKB=F7F210	Alpha-cardiac actin	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02781	Threonine biosynthesis	P03190	Threonine synthase	METJA|EnsemblGenome=MJ_1465|UniProtKB=Q58860	Threonine synthase	ISS	8688087	PubMed	PTHR10314:SF5	THREONINE SYNTHASE 1, CHLOROPLASTIC
P02756	N-acetylglucosamine metabolism	P03040	N-acetylneuraminate lyase	FUSNN|EnsemblGenome=FN1475|UniProtKB=Q8RDN6	N-acetylneuraminate lyase	ISS			PTHR42849:SF1	N-ACETYLNEURAMINATE LYASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MOUSE|MGI=MGI=1859709|UniProtKB=P97492	Regulator of G-protein signaling 14	IDA	8756726	PubMed	PTHR10845:SF179	REGULATOR OF G-PROTEIN SIGNALING 14
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02922	Orotate phosphoribosyltransferase	YARLI|EnsemblGenome=YALI0_F21527g|UniProtKB=P41923	Orotate phosphoribosyltransferase	ISS			PTHR19278:SF9	URIDINE 5'-MONOPHOSPHATE SYNTHASE
P06587	Nicotine pharmacodynamics pathway	P06614	TH	MOUSE|MGI=MGI=98735|UniProtKB=P24529	Tyrosine 3-monooxygenase	RCA	12814656	PubMed	PTHR11473:SF18	TYROSINE 3-MONOOXYGENASE
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	SCHPO|PomBase=SPBC3H7.15|UniProtKB=P40235	Casein kinase I homolog hhp1	IDA	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MACMU|Ensembl=ENSMMUG00000000163|UniProtKB=F7HLV0	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF82	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-6
P06664	Gonadotropin-releasing hormone receptor pathway	P06794	MAP2K1/2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	RCA	94313981	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P02775	Salvage pyrimidine ribonucleotides	P03155	Cytosine deaminase	STRCO|Gene=CAD30959|UniProtKB=Q9ADJ9	Putative deaminase	ISS			PTHR44192:SF2	SUBFAMILY NOT NAMED
P05916	Opioid prodynorphin pathway	P06002	G-protein	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IDA	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05913	Enkephalin release	P05977	G-Protein (s)	CHICK|Ensembl=ENSGALG00000007509|UniProtKB=F1NM72	Uncharacterized protein	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	PANTR|Ensembl=ENSPTRG00000019361|UniProtKB=H2QUV3	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=94926|UniProtKB=P51436	D(4) dopamine receptor	IDA	2039532	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00270	Bcl-2	MOUSE|MGI=MGI=88138|UniProtKB=P10417	Apoptosis regulator Bcl-2	ISS	2250705	PubMed	PTHR11256:SF11	APOPTOSIS REGULATOR BCL-2
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=621025|UniProtKB=Q62711	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	12860966	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	SCHPO|PomBase=SPBC146.13c|UniProtKB=Q9Y7Z8	Myosin-1	IC			PTHR13140:SF663	HEAVY CHAIN, UNCONVENTIONAL MYOSIN
P06587	Nicotine pharmacodynamics pathway	P06593	CHRNA5	PANTR|Gene=CHRNA5|UniProtKB=Q5IS51	Neuronal acetylcholine receptor subunit alpha-5	ISS	12388584	PubMed	PTHR18945:SF76	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5
P00048	PI3 kinase pathway	P01188	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	10463330	OMIM	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00029	Huntington disease	P00777	CBP	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ARATH|TAIR=AT3G46520|UniProtKB=P53497	Actin-12	IC	10974003	PubMed	PTHR11937:SF276	ACTIN-12
P00010	B cell activation	P00391	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04557	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00020	FAS signaling pathway	P00616	Nuclear Lamin	XENTR|Xenbase=XB-GENE-490443|UniProtKB=F6VYL3	Uncharacterized protein	ISS	11165516	PubMed	PTHR23239:SF152	LAMIN-B2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	CANLF|Ensembl=ENSCAFG00000018170|UniProtKB=E2RPM8	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00015	Circadian clock system	P00504	Per	RAT|RGD=727863|UniProtKB=Q8CHI5	Period circadian protein homolog 1	ISS	20570170	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P00036	Interleukin signaling pathway	P00967	c-fos	BOVIN|Ensembl=ENSBTAG00000004322|UniProtKB=O77628	Proto-oncogene c-Fos	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05939	GRK6	MOUSE|MGI=MGI=1347078|UniProtKB=O70293	G protein-coupled receptor kinase 6	RCA	12032308	PubMed	PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P00057	Wnt signaling pathway	P01448	CBP	BOVIN|Ensembl=ENSBTAG00000016198|UniProtKB=E1B8D6	Uncharacterized protein	ISS	8413673	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	TAS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF330	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00990	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04552	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IDA	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00012	Cadherin signaling pathway	P00465	TCF/LEF	HUMAN|HGNC=11641|UniProtKB=Q9NQB0	Transcription factor 7-like 2	ISS	12176738	PubMed	PTHR10373:SF32	TRANSCRIPTION FACTOR 7-LIKE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ARATH|TAIR=AT2G18170|UniProtKB=Q39027	Mitogen-activated protein kinase 7	ISS	10851062	PubMed	PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	CANLF|Ensembl=ENSCAFG00000003156|UniProtKB=F1PYS6	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF462	MYOSIN-14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P06664	Gonadotropin-releasing hormone receptor pathway	P06766	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	RCA	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00005	Angiogenesis	P00218	STAT1	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	14984365	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00034	Integrin signalling pathway	P00907	ERK	CHICK|Ensembl=ENSGALG00000004690|UniProtKB=Q5F3W3	Mitogen-activated protein kinase 6	ISS	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	YEAST|SGD=S000005854|UniProtKB=P33328	Synaptobrevin homolog 2	IC			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00034	Integrin signalling pathway	P00944	Actin	ORNAN|Ensembl=ENSOANG00000007581|UniProtKB=F6QWB7	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00046	Oxidative stress response	P01127	eEF2K	MACMU|Ensembl=ENSMMUG00000017725|UniProtKB=F7F8P2	Uncharacterized protein	ISS	11500363	PubMed	PTHR14187:SF56	EUKARYOTIC ELONGATION FACTOR 2 KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	HUMAN|HGNC=708|UniProtKB=O15511	Actin-related protein 2/3 complex subunit 5	ISS	9230079	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00048	PI3 kinase pathway	P01192	p110	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	IGI	14526383	PubMed	PTHR10048:SF14	PI-3 KINASE
P00047	PDGF signaling pathway	P01145	c-fos	HUMAN|HGNC=3796|UniProtKB=P01100	Proto-oncogene c-Fos	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P05916	Opioid prodynorphin pathway	P06002	G-protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00054	Toll receptor signaling pathway	P01338	IkappaB	MOUSE|MGI=MGI=104741|UniProtKB=Q9Z1E3	NF-kappa-B inhibitor alpha	ISS	10869418	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00049	Parkinson disease	P01238	14-3-3	CANAL|CGD=CAL0000198341|UniProtKB=O42766	14-3-3 protein homolog	IDA	21626410	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00557	PI3K	CAEEL|WormBase=WBGene00006932|UniProtKB=Q9TXI7	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	21924698	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00006	Apoptosis signaling pathway	P00269	MAPK	ANOGA|Gene=AgaP_AGAP009207|UniProtKB=Q7PVR1	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00021	FGF signaling pathway	P00629	PP2A	ANOGA|EnsemblGenome=AGAP010172|UniProtKB=Q7PD38	Serine/threonine-protein phosphatase	ISS	92111736	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	XENTR|Xenbase=XB-GENE-973433|UniProtKB=Q28FH0	Guanine nucleotide binding protein (G protein), q polypeptide	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	MOUSE|MGI=MGI=97453|UniProtKB=P35454	Oxytocin-neurophysin 1	ISS	192340	OMIM	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00015	Circadian clock system	G01497	cry	BOVIN|Ensembl=ENSBTAG00000010149|UniProtKB=F1MXB2	Uncharacterized protein	ISS	10428031	PubMed	PTHR11455:SF16	CRYPTOCHROME-1
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000022550|UniProtKB=F6Y9I6	Serine/threonine-protein kinase	ISS	8078925	PubMed	PTHR22968:SF9	SERINE/THREONINE-PROTEIN KINASE D1
P00006	Apoptosis signaling pathway	P00269	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00648	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	IGI	10644715	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	CAEBR|Gene=CBG03104|UniProtKB=A8WSS5	Protein CBG03104	ISS			PTHR23359:SF145	GTP:AMP PHOSPHOTRANSFERASE, MITOCHONDRIAL
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	10693759	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00059	p53 pathway	P04623	CBP	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	IDA	8413673	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00048	PI3 kinase pathway	P01196	PDK1	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00036	Interleukin signaling pathway	P00976	GSK3	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	YEAST|SGD=S000000028|UniProtKB=P31109	Synaptobrevin homolog 1	ISS	11691998	PubMed	PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00054	Toll receptor signaling pathway	G01550	Gene trancription	MACMU|Ensembl=ENSMMUG00000015248|UniProtKB=F6VUJ0	Uncharacterized protein	ISS	11331040	PubMed	PTHR45200:SF1	INTERLEUKIN-18
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00059	p53 pathway	P01486	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ORYSJ|EnsemblGenome=OS05G0438800|UniProtKB=Q75HX0	Actin	IC	11889126	PubMed	PTHR11937:SF248	SUBFAMILY NOT NAMED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=18539|UniProtKB=P61266	Syntaxin-1B	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	TAKRU|Ensembl=ENSTRUG00000014419|UniProtKB=H2UIU6	Uncharacterized protein	ISS	10940259	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	HUMAN|HGNC=129|UniProtKB=P68133	Actin, alpha skeletal muscle	IEP	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IGI	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00021	FGF signaling pathway	P00627	ERK1-2	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00006	Apoptosis signaling pathway	P00274	JNK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04395	Vasopressin synthesis	P04589	Signal Peptidase	ARATH|TAIR=AT3G15710|UniProtKB=Q9LW08	Signal peptidase I	IC	2092035	PubMed	PTHR10806:SF6	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	BOVIN|Gene=SLC18A2|UniProtKB=Q27963	Synaptic vesicular amine transporter	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00005	Angiogenesis	P00236	PI3K	XENTR|Xenbase=XB-GENE-6067221|UniProtKB=F6Z0J4	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00562	p38	SCHPO|PomBase=SPAC24B11.06c|UniProtKB=Q09892	Mitogen-activated protein kinase sty1	ISS			PTHR24055:SF247	MITOGEN-ACTIVATED PROTEIN KINASE HOG1
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05913	Enkephalin release	P05975	GPCR (s)	DANRE|ZFIN=ZDB-GENE-010125-1|UniProtKB=B8JHS2	Uncharacterized protein	ISS	11259487	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P04393	Ras Pathway	P04553	PAK	HUMAN|HGNC=8592|UniProtKB=O75914	Serine/threonine-protein kinase PAK 3	IDA	11259591	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04496	Mdm2	BOVIN|Gene=MDM4|UniProtKB=Q2HJ21	Protein Mdm4	ISS			PTHR13844:SF20	PROTEIN MDM4
P00005	Angiogenesis	P00218	STAT1	DANRE|ZFIN=ZDB-GENE-980526-499|UniProtKB=Q6P943	Signal transducer and activator of transcription	ISS	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P04393	Ras Pathway	P04542	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04547	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	21150461	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P05913	Enkephalin release	P05972	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	ISS	1319556	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00870	IL2	MACMU|Ensembl=ENSMMUG00000021093|UniProtKB=P68291	Interleukin-2	RCA			PTHR45426:SF1	INTERLEUKIN-2
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	RAT|RGD=1306882|UniProtKB=B4F7A9	Casein kinase 2, alpha prime polypeptide	ISS	10617630	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00555	MKK4,7	BOVIN|Ensembl=ENSBTAG00000012103|UniProtKB=A5PJP8	MAP2K4 protein	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	LEIMA|Gene=LmjF06.0860|UniProtKB=P07382	Bifunctional dihydrofolate reductase-thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02746	Heme biosynthesis	P02981	Glutamate-1-semialdehyde aminotransferase	ORYSJ|EnsemblGenome=OS08G0532200|UniProtKB=Q6YZE2	Glutamate-1-semialdehyde 2,1-aminomutase, chloroplastic	ISS			PTHR43713:SF2	GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE 1, CHLOROPLASTIC-RELATED
P04398	p53 pathway feedback loops 2	P04667	p21	RAT|RGD=69328|UniProtKB=Q64315	Cyclin-dependent kinase inhibitor 1A	IGI	7774811	PubMed	PTHR10265:SF16	CYCLIN-DEPENDENT KINASE INHIBITOR 1
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02749	Leucine biosynthesis	P03002	Isopropylmalate isomerase	SCHPO|PomBase=SPAC9E9.03|UniProtKB=O14289	3-isopropylmalate dehydratase	ISS			PTHR43822:SF3	3-ISOPROPYLMALATE DEHYDRATASE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	RAT|RGD=2732|UniProtKB=P22756	Glutamate receptor ionotropic, kainate 1	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04585	TRH	XENTR|Xenbase=XB-GENE-478483|UniProtKB=F6W2E6	Glycoprotein hormones alpha chain	ISS			PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P00049	Parkinson disease	P01236	Casein kinase II	ARATH|TAIR=AT2G44680|UniProtKB=O80507	Putative casein kinase II subunit beta-4	IDA	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00010	B cell activation	P00379	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	G01575	GADD45	MACMU|Ensembl=ENSMMUG00000003468|UniProtKB=F7EBI6	Growth arrest and DNA damage-inducible protein GADD45 beta	ISS	10097101	PubMed	PTHR10411:SF5	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 BETA
P00025	Hedgehog signaling pathway	P00682	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04654	Rb	BOVIN|Ensembl=ENSBTAG00000011541|UniProtKB=E1BMR3	Uncharacterized protein	ISS			PTHR13742:SF20	RETINOBLASTOMA-LIKE PROTEIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00004	Alzheimer disease-presenilin pathway	P00148	Erb-B4 N-terminal fragment	MONDO|Ensembl=ENSMODG00000015755|UniProtKB=F6ZSZ9	Uncharacterized protein (Fragment)	ISS	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ORYSJ|EnsemblGenome=OS05G0106600|UniProtKB=Q65XH8	Os05g0106600 protein	IC	14684598	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00805	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	14560023	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04616	PDK1/2	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	TAS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00018	EGF receptor signaling pathway	P00543	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00005	Angiogenesis	P00235	c-Fos	RAT|RGD=2626|UniProtKB=P12841	Proto-oncogene c-Fos	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00013	Cell cycle	P00481	APC	CANLF|Ensembl=ENSCAFG00000007566|UniProtKB=E2R745	Anaphase-promoting complex subunit 10	ISS	7657035	gi	PTHR12936:SF0	ANAPHASE-PROMOTING COMPLEX SUBUNIT 10
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	PANTR|Ensembl=ENSPTRG00000023608|UniProtKB=H2QZZ2	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00035	Interferon-gamma signaling pathway	P00960	PTP	PANTR|Ensembl=ENSPTRG00000042397|UniProtKB=H2RIH8	Tyrosine-protein phosphatase non-receptor type	ISS	1382983	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00046	Oxidative stress response	P01135	p38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00054	Toll receptor signaling pathway	P01375	JNK	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	ISS	8946915	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	MONDO|Gene=KRAS|UniProtKB=Q07983	GTPase KRas	ISS	99084794	PubMed	PTHR24070:SF186	GTPASE KRAS
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	NEUCR|EnsemblGenome=EFNCRG00000000159|UniProtKB=F5HH30	Guanine nucleotide-binding protein beta subunit	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	BOVIN|Gene=CHRNA3|UniProtKB=Q07263	Neuronal acetylcholine receptor subunit alpha-3	ISS	18005395	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05916	Opioid prodynorphin pathway	G06050	prepropressophysin	TAKRU|Ensembl=ENSTRUG00000015631|UniProtKB=H2USP0	Uncharacterized protein	ISS			PTHR11681:SF14	SUBFAMILY NOT NAMED
P04376	5HT4 type receptor mediated signaling pathway	P04427	5HT4 Receptor	PANTR|Ensembl=ENSPTRG00000017389|UniProtKB=H2R334	Uncharacterized protein	ISS	12181435	PubMed	PTHR44399:SF3	5-HYDROXYTRYPTAMINE RECEPTOR 4
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	CHICK|Ensembl=ENSGALG00000002479|UniProtKB=E1C735	S-adenosylmethionine synthase	ISS			PTHR11964:SF11	S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-1
P00004	Alzheimer disease-presenilin pathway	P00165	E-cadherin N-terminal fragment	PANTR|Ensembl=ENSPTRG00000008269|UniProtKB=H2QBE4	Cadherin 3, type 1, P-cadherin (Placental)	ISS	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P00045	Notch signaling pathway	P01099	Notch	RAT|RGD=3188|UniProtKB=Q9QW30	Neurogenic locus notch homolog protein 2	IEP	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P05916	Opioid prodynorphin pathway	P06000	vasopressin	TAKRU|Ensembl=ENSTRUG00000015413|UniProtKB=H2UR30	Uncharacterized protein	ISS			PTHR11681:SF13	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00973	PKB	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00310	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01458	Protein Kinase C	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01168	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00009	Axon guidance mediated by netrin	P00366	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00046	Oxidative stress response	P01131	MKP5	MOUSE|MGI=MGI=1914696|UniProtKB=Q8BTR5	Dual specificity phosphatase 28	ISS			PTHR10159:SF116	DUAL SPECIFICITY PHOSPHATASE 28
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00038	JAK/STAT signaling pathway	P01027	STAT	HUMAN|HGNC=11367|UniProtKB=P51692	Signal transducer and activator of transcription 5B	ISS	8732682	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=4599|UniProtKB=Q14831	Metabotropic glutamate receptor 7	IDA	12488551	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00010	B cell activation	P00372	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	12748278	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00047	PDGF signaling pathway	P01161	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	CANLF|Ensembl=ENSCAFG00000017679|UniProtKB=E2RMD8	Ribosomal protein S6 kinase	ISS	11861821	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ORYSJ|EnsemblGenome=OS03G0836000|UniProtKB=Q10AZ4	Actin-3	IC	14684598	PubMed	PTHR11937:SF254	ACTIN-1-RELATED
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00021	FGF signaling pathway	P00638	PLCgamma	CAEEL|WormBase=WBGene00004038|UniProtKB=Q22070	Phosphoinositide phospholipase C	ISS			PTHR10336:SF91	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IDA	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05918	p38 MAPK pathway	P06041	Cdc42	BRAFL|Gene=BRAFLDRAFT_122664|UniProtKB=C3ZIB9	Putative uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00056	VEGF signaling pathway	P01425	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	10644715	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00020	FAS signaling pathway	P00605	Pro-Caspase7	BOVIN|Ensembl=ENSBTAG00000006615|UniProtKB=F1MD58	Uncharacterized protein	ISS	14583630	PubMed	PTHR10454:SF31	CASPASE-7
P00054	Toll receptor signaling pathway	P01355	AP1	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00036	Interleukin signaling pathway	P00973	PKB	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00520	Rho GAPs	HUMAN|HGNC=673|UniProtKB=Q07960	Rho GTPase-activating protein 1	ISS	14724572	PubMed	PTHR23176:SF28	RHO GTPASE-ACTIVATING PROTEIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	IC	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00052	TGF-beta signaling pathway	P01286	TGFbeta	CANLF|Gene=TGFB1|UniProtKB=P54831	Transforming growth factor beta-1	TAS	9759503	PubMed	PTHR11848:SF125	TRANSFORMING GROWTH FACTOR BETA-1
P00048	PI3 kinase pathway	P01179	PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00045	Notch signaling pathway	P01118	Numb	BOVIN|Ensembl=ENSBTAG00000011683|UniProtKB=E1B8G1	Uncharacterized protein	ISS	8755477	PubMed	PTHR11232:SF33	PROTEIN NUMB HOMOLOG
P00059	p53 pathway	P01485	p53	HUMAN|HGNC=11998|UniProtKB=P04637	Cellular tumor antigen p53	TAS	11313951	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00057	Wnt signaling pathway	P01438	PP2A	CHICK|Ensembl=ENSGALG00000011840|UniProtKB=F1NLM6	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P06210	Activin beta signaling pathway	P06234	activin beta	DROME|FlyBase=FBgn0024913|UniProtKB=O61643	Inhibin beta chain	IEA	9618266	PubMed	PTHR11848:SF133	INHIBIN BETA A CHAIN
P00047	PDGF signaling pathway	P01165	SRF	MONDO|Ensembl=ENSMODG00000018981|UniProtKB=F7FP88	Uncharacterized protein	ISS	8660892	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00019	Endothelin signaling pathway	P00566	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05731	GABA-B receptor II signaling	P05754	Ggamma	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00037	Ionotropic glutamate receptor pathway	P01016	Glu3	HUMAN|HGNC=4573|UniProtKB=P42263	Glutamate receptor 3	IC	12871085	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00047	PDGF signaling pathway	P01161	Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	ISS	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05924	AT1-R	HUMAN|HGNC=336|UniProtKB=P30556	Type-1 angiotensin II receptor	RCA			PTHR24228:SF11	TYPE-1 ANGIOTENSIN II RECEPTOR
P04393	Ras Pathway	P04572	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P06664	Gonadotropin-releasing hormone receptor pathway	P06850	PKCs(3)	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	RCA	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P06587	Nicotine pharmacodynamics pathway	P06600	CACNA	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P05913	Enkephalin release	P05972	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05731	GABA-B receptor II signaling	P05752	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MONDO|Ensembl=ENSMODG00000029104|UniProtKB=K7E376	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04398	p53 pathway feedback loops 2	P04665	AKT	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	12655147	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	DANRE|ZFIN=ZDB-GENE-040426-1013|UniProtKB=Q6P0T2	Transcription initiation factor TFIID subunit 8	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00718	Phosphorylase a	MACMU|Ensembl=ENSMMUG00000009199|UniProtKB=F7HK11	Alpha-1,4 glucan phosphorylase	ISS	4318782	PubMed	PTHR11468:SF1	GLYCOGEN PHOSPHORYLASE, BRAIN FORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	TAS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00057	Wnt signaling pathway	P01465	Ggamma	DANRE|ZFIN=ZDB-GENE-010705-1|UniProtKB=Q90Z40	Guanine nucleotide-binding protein subunit gamma	IDA	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P02769	Purine metabolism	P03118	Guanine Deaminase	RAT|RGD=621617|UniProtKB=Q9WTT6	Guanine deaminase	NAS	7533042	gi	PTHR11271:SF6	GUANINE DEAMINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01275	P38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CANAL|CGD=CAL0064759|UniProtKB=Q5AKX0	Uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02776	Serine glycine biosynthesis	P03157	Phosphoserine aminotransferase	MACMU|Ensembl=ENSMMUG00000011868|UniProtKB=F7H2J8	Phosphoserine aminotransferase	ISS	2682527	PubMed	PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P00029	Huntington disease	G01535	PIG3	NEUCR|EnsemblGenome=EFNCRG00000004116|UniProtKB=Q1K6M1	Quinone oxidoreductase	TAS	12932731	PubMed	PTHR43006:SF2	QUINONE OXIDOREDUCTASE PIG3
P02743	Formyltetrahydroformate biosynthesis	P02954	Thymidylate synthase	MYCTU|EnsemblGenome=Rv2764c|UniProtKB=P9WFR9	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00057	Wnt signaling pathway	P01465	Ggamma	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00005	Angiogenesis	P00213	FGF	MACMU|Ensembl=ENSMMUG00000007419|UniProtKB=F6SXE2	Fibroblast growth factor	ISS	91095983	PubMed	PTHR11486:SF83	FIBROBLAST GROWTH FACTOR 2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00024	Glycolysis	P00678	Enolase	TAKRU|Ensembl=ENSTRUG00000009070|UniProtKB=H2TDQ9	Uncharacterized protein	ISS	89079778	PubMed	PTHR11902:SF12	ALPHA-ENOLASE
P00029	Huntington disease	P00790	beta-Tubulin	HUMAN|HGNC=20773|UniProtKB=Q3ZCM7	Tubulin beta-8 chain	TAS	9454836	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00018	EGF receptor signaling pathway	P00547	PP2A	ORYSJ|EnsemblGenome=OS06G0574500|UniProtKB=Q0DBD3	Serine/threonine-protein phosphatase PP2A-1 catalytic subunit	ISS			PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	PANTR|Ensembl=ENSPTRG00000012660|UniProtKB=H2QJ07	Activating transcription factor 2	ISS	9819389	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DICDI|dictyBase=DDB_G0289487|UniProtKB=P07829	Actin-3	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00019	Endothelin signaling pathway	P00573	signal peptidase	CANLF|Ensembl=ENSCAFG00000000100|UniProtKB=P13679	Signal peptidase complex catalytic subunit SEC11C	ISS	2092035	PubMed	PTHR10806:SF12	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11C
P05730	Endogenous cannabinoid signaling	P05746	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00015	Circadian clock system	G01501	cry	CANLF|Ensembl=ENSCAFG00000009379|UniProtKB=F1PNC9	Uncharacterized protein	ISS	11804325	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P02777	Succinate to proprionate conversion	P03161	Methylmalonyl-CoA mutase	MACMU|Ensembl=ENSMMUG00000002458|UniProtKB=F7HGZ4	Methylmalonyl-CoA mutase, mitochondrial	ISS			PTHR42710:SF1	METHYLMALONYL-COA MUTASE, MITOCHONDRIAL
P00009	Axon guidance mediated by netrin	P00366	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P06587	Nicotine pharmacodynamics pathway	P06591	GNB	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00021	FGF signaling pathway	P00627	ERK1-2	ORYSJ|EnsemblGenome=OS03G0285800|UniProtKB=Q10N20	Mitogen-activated protein kinase 5	ISS			PTHR24055:SF214	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00019	Endothelin signaling pathway	P00578	eNOS	PANTR|Ensembl=ENSPTRG00000019868|UniProtKB=H2QVM2	Nitric oxide synthase	ISS	93055452	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00018	EGF receptor signaling pathway	P00557	PI3K	ANOGA|Gene=AgaP_AGAP010273|UniProtKB=Q7PMF0	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00010	B cell activation	P00402	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00643	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=11429|UniProtKB=O75558	Syntaxin-11	IC	11067767	PubMed	PTHR19957:SF30	SYNTAXIN-11
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	CAEEL|WormBase=WBGene00001187|UniProtKB=Q8MQA1	Uncharacterized protein	IC	9199552	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008018|UniProtKB=F7EPG4	Uncharacterized protein	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	BOVIN|Ensembl=ENSBTAG00000020887|UniProtKB=F1MP22	Uncharacterized protein	ISS	14624853	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00016	Cytoskeletal regulation by Rho GTPase	P00508	Cofilin	BOVIN|Ensembl=ENSBTAG00000021455|UniProtKB=Q5E9F7	Cofilin-1	ISS			PTHR11913:SF17	COFILIN-1
P00029	Huntington disease	P00778	NMDA receptor	RAT|RGD=2739|UniProtKB=Q00961	Glutamate receptor ionotropic, NMDA 2C	IDA	14698601	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P04393	Ras Pathway	P04542	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00227	PLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04397	p53 pathway by glucose deprivation	P04641	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04395	Vasopressin synthesis	P04594	Neurophysin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04371	5-Hydroxytryptamine biosynthesis	P04400	Aromatic L-amino acid decarboxylase	MACMU|Ensembl=ENSMMUG00000019991|UniProtKB=F7FNW0	Aromatic-L-amino-acid decarboxylase	ISS	107930	OMIM	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00047	PDGF signaling pathway	P01167	Ets	BOVIN|Gene=FLI1|UniProtKB=Q29RS8	Friend leukemia integration 1 transcription factor	ISS	15298723	PubMed	PTHR11849:SF161	FRIEND LEUKEMIA INTEGRATION 1 TRANSCRIPTION FACTOR
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MOUSE|MGI=MGI=87902|UniProtKB=P68134	Actin, alpha skeletal muscle	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00059	p53 pathway	P04609	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	8262392	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00007	Axon guidance mediated by semaphorins	P00341	Rho	CHICK|Ensembl=ENSGALG00000003806|UniProtKB=O93467	GTP-binding protein	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00029	Huntington disease	P00778	NMDA receptor	ANOGA|EnsemblGenome=AGAP001478|UniProtKB=Q7PXM3	AGAP001478-PA	IDA	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00029	Huntington disease	P00805	Akt	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	IDA	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00020	FAS signaling pathway	P00610	MKK4	DROME|FlyBase=FBgn0024326|UniProtKB=O61444	MAP kinase kinase 4, isoform A	TAS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00034	Integrin signalling pathway	P00922	Collagen	ANOGA|Gene=AgaP_AGAP009200|UniProtKB=Q7PVR8	AGAP009200-PA (Fragment)	IDA			PTHR24023:SF674	COLLAGEN ALPHA-1 IV  CHAIN-RELATED
P00005	Angiogenesis	P00221	JNK1	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	PANTR|Ensembl=ENSPTRG00000018669|UniProtKB=H2QTU8	Adenosine deaminase, tRNA-specific 2, TAD2 homolog	ISS			PTHR11079:SF92	TRNA-SPECIFIC ADENOSINE DEAMINASE 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00054	Toll receptor signaling pathway	P01369	MKK1	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CAEBR|Gene=CBG05896|UniProtKB=A8X1E0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF147	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P02738	De novo purine biosynthesis	P02903	Phosphoribosylglycinamide  formyltransferase	ARATH|TAIR=AT1G31220|UniProtKB=P52422	Phosphoribosylglycinamide formyltransferase, chloroplastic	ISS			PTHR43369:SF2	PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	HUMAN|HGNC=10433|UniProtKB=O75676	Ribosomal protein S6 kinase alpha-4	ISS	9792677	PubMed	PTHR24351:SF41	RIBOSOMAL PROTEIN S6 KINASE ALPHA-4
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	IDA	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P02738	De novo purine biosynthesis	P02909	GDP reductase	RAT|RGD=1598310|UniProtKB=Q4KLN6	Ribonucleoside-diphosphate reductase subunit M2	ISS			PTHR23409:SF20	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00029	Huntington disease	P00778	NMDA receptor	CHICK|Ensembl=ENSGALG00000011809|UniProtKB=F1NMB0	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P02775	Salvage pyrimidine ribonucleotides	P03151	Uracil phosphoribosyl  transferase	THEMA|EnsemblGenome=TM_0721|UniProtKB=Q9WZI0	Uracil phosphoribosyltransferase	ISS			PTHR10285:SF46	URACIL PHOSPHORIBOSYLTRANSFERASE, CHLOROPLASTIC
P00010	B cell activation	P00381	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00317	Fos	RAT|RGD=2626|UniProtKB=P12841	Proto-oncogene c-Fos	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00034	Integrin signalling pathway	P00906	Rap1	RAT|RGD=620577|UniProtKB=Q62636	Ras-related protein Rap-1b	IPI	8576107	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P04393	Ras Pathway	P04559	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00005	Angiogenesis	P00206	Wnt	CANLF|Ensembl=ENSCAFG00000014987|UniProtKB=E2RH98	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	MONDO|Ensembl=ENSMODG00000009618|UniProtKB=F6REU0	Uncharacterized protein	ISS	10514528	PubMed	PTHR11824:SF9	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	HUMAN|HGNC=1388|UniProtKB=O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	IDA	14507926	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P02768	Proline biosynthesis	P03114	Glutamyl kinase	YEAST|SGD=S000001075|UniProtKB=P38690	Uncharacterized protein YHR033W	ISS			PTHR43654:SF3	GLUTAMATE 5-KINASE
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	10188796	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	92020947	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00206	Wnt	MOUSE|MGI=MGI=98961|UniProtKB=P24383	Protein Wnt-7a	ISS	12549854	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00059	p53 pathway	P04623	CBP	ARATH|TAIR=AT1G16710|UniProtKB=Q9FWQ5	Histone acetyltransferase HAC12	ISS	10769018	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	DROME|FlyBase=FBgn0036629|UniProtKB=Q9VV59	CG4573	ISS			PTHR43311:SF2	GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	DANRE|ZFIN=ZDB-GENE-051202-1|UniProtKB=E7F101	Uncharacterized protein	ISS	11554554	PubMed	PTHR44391:SF2	SUBFAMILY NOT NAMED
P00001	Adrenaline and noradrenaline biosynthesis	P00071	VAT1	BOVIN|Gene=SLC18A2|UniProtKB=Q27963	Synaptic vesicular amine transporter	ISS			PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00049	Parkinson disease	P01230	Src kinase	MACMU|Ensembl=ENSMMUG00000015267|UniProtKB=F7GRP2	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P02747	Histidine biosynthesis	P02984	Imidazol glycerol phosphate dehydratase	RHOBA|EnsemblGenome=RB7662|UniProtKB=Q7UNC2	Imidazoleglycerol-phosphate dehydratase	ISS			PTHR23133:SF2	IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=4600|UniProtKB=O00222	Metabotropic glutamate receptor 8	IDA	12351712	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00025	Hedgehog signaling pathway	P00682	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	8787761	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	RCA	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01319	PAK	XENTR|Xenbase=XB-GENE-961764|UniProtKB=F6W3Y0	Uncharacterized protein	ISS	7559398	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00054	Toll receptor signaling pathway	G01550	Gene trancription	MACMU|Ensembl=ENSMMUG00000019067|UniProtKB=B6CK14	Interferon beta 1	ISS			PTHR11691:SF43	INTERFERON BETA
P00006	Apoptosis signaling pathway	P00260	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00054	Toll receptor signaling pathway	P01375	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02738	De novo purine biosynthesis	P02902	ADP reductase	ORYSJ|EnsemblGenome=OS06G0168600|UniProtKB=Q5VRF5	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00008	Axon guidance mediated by Slit/Robo	P00351	Cxcr4	XENTR|Xenbase=XB-GENE-489917|UniProtKB=Q07FZ4	C-X-C chemokine receptor type 4	ISS	4503175	gi	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P00005	Angiogenesis	P00218	STAT1	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	14755057	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	P01465	Ggamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DROME|FlyBase=FBgn0010223|UniProtKB=Q05337	Guanine nucleotide-binding protein G(f) subunit alpha	IC	14765990	PubMed	PTHR10218:SF229	GUANINE NUCLEOTIDE-BINDING PROTEIN G F  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01428	Frizzled	MOUSE|MGI=MGI=108520|UniProtKB=Q61088	Frizzled-4	IDA	11212302	PubMed	PTHR11309:SF23	FRIZZLED-4
P00003	Alzheimer disease-amyloid secretase pathway	P00095	Nicastrin	RAT|RGD=631418|UniProtKB=Q8CGU6	Nicastrin	IDA	16096062	PubMed	PTHR21092:SF0	NICASTRIN
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01065	VAChT	PANTR|Ensembl=ENSPTRG00000002490|UniProtKB=H2Q1W2	Uncharacterized protein	ISS	7938002	PubMed	PTHR23506:SF13	VESICULAR ACETYLCHOLINE TRANSPORTER
P00034	Integrin signalling pathway	P00944	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g234494|UniProtKB=A7RU31	Predicted protein	ISS	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00047	PDGF signaling pathway	P01162	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00045	Notch signaling pathway	P01110	Presenilin	DROME|FlyBase=FBgn0019947|UniProtKB=O02194	Presenilin homolog	TAS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DICPU|Gene=DICPUDRAFT_46519|UniProtKB=F0Z796	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P02783	Tryptophan biosynthesis	P03210	Indole-3-glycerol phosphate synthase	THEMA|EnsemblGenome=TM_0140|UniProtKB=Q56319	Indole-3-glycerol phosphate synthase	ISS			PTHR22854:SF2	TRYPTOPHAN BIOSYNTHESIS PROTEIN TRPCF
P00056	VEGF signaling pathway	P01417	Raf	DROME|FlyBase=FBgn0003079|UniProtKB=P11346	Raf homolog serine/threonine-protein kinase phl	ISS	125651	gi	PTHR44000:SF2	RAF HOMOLOG SERINE/THREONINE-PROTEIN KINASE PHL
P00034	Integrin signalling pathway	P00907	ERK	BOVIN|Ensembl=ENSBTAG00000004216|UniProtKB=F1MSX4	Uncharacterized protein	ISS			PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00056	VEGF signaling pathway	P01407	Erk	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01155	Jak	BOVIN|Ensembl=ENSBTAG00000020904|UniProtKB=E1BEL4	Tyrosine-protein kinase	ISS	15179321	PubMed	PTHR24418:SF233	TYROSINE-PROTEIN KINASE JAK3
P00047	PDGF signaling pathway	P01148	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8051109	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00021	FGF signaling pathway	P00643	Raf-1	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS			PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	IXOSC|EnsemblGenome=ISCW003614|UniProtKB=B7PHY7	Cdc42 protein, putative	ISS	15723050	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	HUMAN|HGNC=5464|UniProtKB=P05019	Insulin-like growth factor I	ISS			PTHR11454:SF4	INSULIN-LIKE GROWTH FACTOR I
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04393	Ras Pathway	P04558	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P02775	Salvage pyrimidine ribonucleotides	P03149	Cytidine kinase	MOUSE|MGI=MGI=1931744|UniProtKB=Q99PM9	Uridine-cytidine kinase 2	ISS			PTHR10285:SF70	URIDINE-CYTIDINE KINASE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	RCA	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00005	Angiogenesis	P00199	JNKK1	MOUSE|MGI=MGI=1346869|UniProtKB=P47809	Dual specificity mitogen-activated protein kinase kinase 4	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	HUMAN|HGNC=1391|UniProtKB=Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	8838325	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	IC	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	TAS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00009	Axon guidance mediated by netrin	P00356	UNC-5	BOVIN|Ensembl=ENSBTAG00000014270|UniProtKB=A5PJP9	UNC5B protein	ISS			PTHR12582:SF6	NETRIN RECEPTOR UNC5B
P00036	Interleukin signaling pathway	P00981	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00015	Circadian clock system	P00504	Per	CANLF|Ensembl=ENSCAFG00000016984|UniProtKB=E2R0I6	Uncharacterized protein	ISS	20570170	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01185	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P04375	5HT3 type receptor mediated signaling pathway	P04421	5HT transporter	RAT|RGD=3714|UniProtKB=P31652	Sodium-dependent serotonin transporter	ISS	7681602	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00053	T cell activation	P01308	ZAP-70	BOVIN|Ensembl=ENSBTAG00000005892|UniProtKB=E1BMP9	Tyrosine-protein kinase	ISS	1423621	PubMed	PTHR24418:SF369	TYROSINE-PROTEIN KINASE ZAP-70
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT4G01370|UniProtKB=Q39024	Mitogen-activated protein kinase 4	ISS	11707292	PubMed	PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P00005	Angiogenesis	P00249	PAK	MONDO|Ensembl=ENSMODG00000005255|UniProtKB=F7G800	Uncharacterized protein	ISS	7559398	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00010	B cell activation	P00371	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	MACMU|Ensembl=ENSMMUG00000014817|UniProtKB=F6VXD8	Uncharacterized protein	ISS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00057	Wnt signaling pathway	P01443	Phospholipase C	ANOGA|Gene=AgaP_AGAP009115|UniProtKB=Q7PW25	Phosphoinositide phospholipase C (Fragment)	ISS	12860966	PubMed	PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DANRE|ZFIN=ZDB-GENE-000322-1|UniProtKB=Q9I8V1	Actin, alpha 1, skeletal muscle	ISS	11889139	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00274	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	ISS	11371355	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	CHICK|Gene=TBP|UniProtKB=O13270	TATA-box-binding protein	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00005	Angiogenesis	P00243	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	IPI	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	PANTR|Ensembl=ENSPTRG00000023608|UniProtKB=H2QZZ2	Uncharacterized protein	ISS	11554549	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01040	mGluR 1/5	MOUSE|MGI=MGI=1351342|UniProtKB=Q3UVX5	Metabotropic glutamate receptor 5	ISS	12351712	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00892	Grb2	CAEEL|WormBase=WBGene00004774|UniProtKB=P29355	Sex muscle abnormal protein 5	ISS	17569445	gi	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MACMU|Ensembl=ENSMMUG00000007610|UniProtKB=F6SDH6	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF41	RIBOSOMAL PROTEIN S6 KINASE ALPHA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	IDA	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02738	De novo purine biosynthesis	P02900	AICAR transformylase	CHICK|Gene=ATIC|UniProtKB=P31335	Bifunctional purine biosynthesis protein PURH	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P02738	De novo purine biosynthesis	P02907	dADP kinase	DEIRA|EnsemblGenome=DR_2499|UniProtKB=Q9RRJ1	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	HUMAN|HGNC=1950|UniProtKB=P11229	Muscarinic acetylcholine receptor M1	TAS	10069496	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	IC	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01036	EAAT	HUMAN|HGNC=10939|UniProtKB=P43005	Excitatory amino acid transporter 3	ISS	94365697	PubMed	PTHR11958:SF69	EXCITATORY AMINO ACID TRANSPORTER 3
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	TAS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00049	Parkinson disease	P01219	SAPK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P02775	Salvage pyrimidine ribonucleotides	P03150	Uridine kinase	ARATH|TAIR=AT1G26190|UniProtKB=Q9C664	Phosphoribulokinase/uridine kinase-like protein	ISS			PTHR10285:SF122	URIDINE-CYTIDINE KINASE C
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00642	MEK1-2	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PANTR|Ensembl=ENSPTRG00000002086|UniProtKB=H2Q1A9	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00018	EGF receptor signaling pathway	P00560	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00016	Cytoskeletal regulation by Rho GTPase	P00514	MLCK	MOUSE|MGI=MGI=2139434|UniProtKB=Q8VCR8	Myosin light chain kinase 2, skeletal/cardiac muscle	ISS	11157482	PubMed	PTHR45210:SF1	MYOSIN LIGHT CHAIN KINASE 2, SKELETAL/CARDIAC MUSCLE
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	IC	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01240	hSel10	PANTR|Ensembl=ENSPTRG00000017526|UniProtKB=H2QS02	Uncharacterized protein	ISS			PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P00059	p53 pathway	G04700	PAI	MOUSE|MGI=MGI=97608|UniProtKB=P22777	Plasminogen activator inhibitor 1	ISS	10692390	PubMed	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00049	Parkinson disease	P01242	Casein kinase I	ARATH|TAIR=AT5G57015|UniProtKB=Q8VYK9	Casein kinase 1-like protein 12	IDA	11437445	PubMed	PTHR11909:SF298	CASEIN KINASE 1-LIKE PROTEIN 12-RELATED
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	MOUSE|MGI=MGI=109583|UniProtKB=O08586	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00053	T cell activation	P01307	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00045	Notch signaling pathway	P01119	NIct	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00010	B cell activation	P00384	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00011	Blood coagulation	P00416	Prothrombin	HUMAN|HGNC=3535|UniProtKB=P00734	Prothrombin	ISS	176930	OMIM	PTHR24254:SF10	PROTHROMBIN
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IDA	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00058	mRNA splicing	P01478	U2	CHICK|Ensembl=ENSGALG00000026999|UniProtKB=R4GH36	Uncharacterized protein	ISS	9716128	PubMed	PTHR10501:SF21	U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B''
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	YEAST|SGD=S000004235|UniProtKB=Q06549	Cytidine deaminase	ISS			PTHR11644:SF2	CYTIDINE DEAMINASE
P00047	PDGF signaling pathway	P01162	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	RCA	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IGI	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	MONDO|Ensembl=ENSMODG00000017905|UniProtKB=F7FG65	Tyrosine-protein kinase	ISS	11162638	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	ARATH|TAIR=AT5G61210|UniProtKB=Q9S7P9	SNAP25 homologous protein SNAP33	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IDA	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00757	beta-arrestin	HUMAN|HGNC=10521|UniProtKB=P10523	S-arrestin	IDA	11742073	PubMed	PTHR11792:SF15	S-ARRESTIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	RCA	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00005	Angiogenesis	P00223	Akt	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	ISS			PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04665	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00240	FRS-2	MOUSE|MGI=MGI=2135965|UniProtKB=Q91WJ0	Fibroblast growth factor receptor substrate 3	ISS			PTHR21258:SF39	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	RCA			PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	CHLRE|EnsemblGenome=CHLREDRAFT_15736|UniProtKB=Q8W1K7	Serine/threonine protein kinase	IDA	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	IC	8836152	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	PANTR|Ensembl=ENSPTRG00000012554|UniProtKB=H2QIU8	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF58	ACTIVIN RECEPTOR TYPE-1C
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IDA	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	8838318	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P04393	Ras Pathway	P04567	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	TAS	15210700	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=108061|UniProtKB=P48614	Protein Wnt-10b	TAS	8717036	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P04393	Ras Pathway	P04567	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00385	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00054	Toll receptor signaling pathway	P01352	p38	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	7937853	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00059	p53 pathway	G01579	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	9072974	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	MONDO|Ensembl=ENSMODG00000009206|UniProtKB=F6YZA3	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	10391901	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MACMU|Ensembl=ENSMMUG00000018272|UniProtKB=F7HEB8	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P05916	Opioid prodynorphin pathway	P06002	G-protein	PHYIT|EnsemblGenome=PITG_06376|UniProtKB=D0N4Q3	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta, putative	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00004	Alzheimer disease-presenilin pathway	P00152	LRP transmembrane fragment	MONDO|Ensembl=ENSMODG00000002847|UniProtKB=F7B627	Uncharacterized protein (Fragment)	ISS	11907044	PubMed	PTHR44025:SF7	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00084	X11alpha	HUMAN|HGNC=580|UniProtKB=O96018	Amyloid beta A4 precursor protein-binding family A member 3	IDA	9614075	PubMed	PTHR12345:SF9	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 3
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	12885769	PubMed	PTHR10202:SF13	PRESENILIN-2
P00057	Wnt signaling pathway	P01465	Ggamma	MACMU|Ensembl=ENSMMUG00000010392|UniProtKB=F7ASR8	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00053	T cell activation	P01330	IKK	CANLF|Ensembl=ENSCAFG00000005526|UniProtKB=E2RKR0	Uncharacterized protein	ISS	14499113	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	ARATH|TAIR=AT5G07880|UniProtKB=Q9SD96	SNAP25 homologous protein SNAP29	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00052	TGF-beta signaling pathway	P01284	JNK	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	IC	2372396	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01452	NFAT	BOVIN|Ensembl=ENSBTAG00000018270|UniProtKB=F1MGR9	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P05734	Synaptic vesicle trafficking	P05774	NSF	BOVIN|Ensembl=ENSBTAG00000008442|UniProtKB=F1MZU2	Uncharacterized protein	ISS	11348590	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00012	Cadherin signaling pathway	P00470	F-actin	XENTR|Xenbase=XB-GENE-480347|UniProtKB=Q6P640	Actin, alpha cardiac muscle 1	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00025	Hedgehog signaling pathway	P00682	PKA	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IDA	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00790	beta-Tubulin	CHICK|GeneID=431043|UniProtKB=P09652	Tubulin beta-4 chain	TAS	9454836	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00021	FGF signaling pathway	P00632	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	TAS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00009	Axon guidance mediated by netrin	P00359	NFAT	RAT|RGD=1308692|UniProtKB=A0A0G2JTY4	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 (Predicted), isoform CRA_b	ISS	9133421	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	DROME|FlyBase=FBgn0001104|UniProtKB=P20353	G protein alpha i subunit	ISS	12488551	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00018	EGF receptor signaling pathway	P00562	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P02778	Sulfate assimilation	P03167	Sulfate adenylyltransferase	ARATH|TAIR=AT4G14680|UniProtKB=O23324	ATP-sulfurylase 3, chloroplastic	ISS			PTHR11055:SF18	ATP SULFURYLASE 1, CHLOROPLASTIC-RELATED
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04392	P53 pathway feedback loops 1	P04539	p53	MOUSE|MGI=MGI=1336991|UniProtKB=Q9JJP2	Tumor protein p73	TAS	15197326	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00034	Integrin signalling pathway	P00927	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	IGI	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00006	Apoptosis signaling pathway	P00269	MAPK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02738	De novo purine biosynthesis	P02902	ADP reductase	STRCO|Gene=CAB94610|UniProtKB=Q9K3C2	Ribonucleoside-diphosphate reductase subunit beta	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00034	Integrin signalling pathway	P00913	Csk	CHICK|Gene=CSK|UniProtKB=P41239	Tyrosine-protein kinase CSK	IDA	7687537	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00011	Blood coagulation	P00458	GP IIIa	BOVIN|Ensembl=ENSBTAG00000009987|UniProtKB=F1MTN1	Integrin beta	ISS	3487386	PubMed	PTHR10082:SF25	INTEGRIN BETA-3
P00030	Hypoxia response via HIF activation	P00819	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01219	SAPK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000016428|UniProtKB=F7GU00	Metabotropic glutamate receptor 1 isoform alpha	ISS			PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00029	Huntington disease	P00778	NMDA receptor	BOVIN|Ensembl=ENSBTAG00000018445|UniProtKB=E1BK87	Uncharacterized protein	ISS	11554549	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00060	Ubiquitin proteasome pathway	P01491	E2	RAT|RGD=620392|UniProtKB=P62255	Ubiquitin-conjugating enzyme E2 G1	ISS			PTHR24067:SF3	UBIQUITIN-CONJUGATING ENZYME E2 G1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01087	CAT	CAEEL|WormBase=WBGene00000481|UniProtKB=P32756	Choline O-acetyltransferase	ISS	97225904	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00019	Endothelin signaling pathway	P00589	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01051	Ca2+	MOUSE|MGI=MGI=88296|UniProtKB=O55017	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	14624853	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00006	Apoptosis signaling pathway	P00318	PKCs	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	22533439	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00005	Angiogenesis	P00237	FRP	PANTR|Ensembl=ENSPTRG00000020122|UniProtKB=H2QVZ0	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF22	FRIZZLED-3
P04398	p53 pathway feedback loops 2	P04661	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	PANTR|Ensembl=ENSPTRG00000001102|UniProtKB=H2QZR9	RAP1A, member of RAS oncogene family	ISS	10476970	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	RAT|RGD=2521|UniProtKB=P19020	D(3) dopamine receptor	ISS	11861492	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00018	EGF receptor signaling pathway	P00551	Akt	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02783	Tryptophan biosynthesis	P03207	Tryptophan synthase A	ECOLI|EcoGene=EG11024|UniProtKB=P0A877	Tryptophan synthase alpha chain	ISS			PTHR43406:SF1	TRYPTOPHAN SYNTHASE ALPHA CHAIN
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	PHYPA|Gene=PHYPADRAFT_185037|UniProtKB=A9SHH7	Predicted protein	ISS	7514101	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00047	PDGF signaling pathway	P01143	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00011	Blood coagulation	P00438	Bradykinin	PANTR|Ensembl=ENSPTRG00000015717|UniProtKB=H2QNX2	Uncharacterized protein	ISS	4504893	gi	PTHR13814:SF12	KININOGEN-1
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00053	T cell activation	P01318	PKC-theta	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IGI	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00029	Huntington disease	P00805	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DANRE|ZFIN=ZDB-GENE-050417-267|UniProtKB=F1QUN8	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF263	ACTIN
P00004	Alzheimer disease-presenilin pathway	P00139	E-cadherin transmembrane fragment	XENTR|Xenbase=XB-GENE-482277|UniProtKB=F6QAX3	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P00054	Toll receptor signaling pathway	P01375	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00081	Pro-BACE-1	MACMU|Ensembl=ENSMMUG00000007785|UniProtKB=F7CQI1	Beta-secretase 1 isoform A preproprotein	ISS	10956649	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04396	Vitamin D metabolism and pathway	P04604	FdxR	DROME|FlyBase=FBgn0015582|UniProtKB=Q9V3T9	NADPH:adrenodoxin oxidoreductase, mitochondrial	ISS			PTHR11938:SF91	NADPH:ADRENODOXIN OXIDOREDUCTASE, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	RAT|RGD=621375|UniProtKB=Q9QY78	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	ANOGA|EnsemblGenome=AGAP000803|UniProtKB=Q7QE65	AGAP000803-PA	IC			PTHR18966:SF350	CLUMSY, ISOFORM B-RELATED
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00038	JAK/STAT signaling pathway	P01027	STAT	PANTR|Ensembl=ENSPTRG00000009200|UniProtKB=H2QD20	Signal transducer and activator of transcription	ISS	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00029	Huntington disease	P00778	NMDA receptor	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	IDA	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00047	PDGF signaling pathway	P01143	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00369	MEKK	MONDO|Ensembl=ENSMODG00000009983|UniProtKB=F6USY2	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00011	Blood coagulation	P00418	Fibrin monomer	RAT|RGD=2604|UniProtKB=P14480	Fibrinogen beta chain	ISS	1706801	gi	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00706	RGS-PX1	MONDO|Ensembl=ENSMODG00000001464|UniProtKB=F7APQ1	Uncharacterized protein (Fragment)	ISS	11729322	PubMed	PTHR22775:SF30	SORTING NEXIN-13
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00049	Parkinson disease	P01208	Hsp70	ORNAN|Ensembl=ENSOANG00000013291|UniProtKB=F6S4U9	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00010	B cell activation	P00391	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	94313981	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05916	Opioid prodynorphin pathway	P06002	G-protein	EMENI|EnsemblGenome=CADANIAG00002670|UniProtKB=Q5BH99	G-protein beta subunit [Source:UniProtKB/TrEMBLAcc:O74214]	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00053	T cell activation	P01318	PKC-theta	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IGI	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00053	T cell activation	P01312	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IDA	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	DROME|FlyBase=FBgn0032650|UniProtKB=Q9VJC2	CG7094	ISS	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P00047	PDGF signaling pathway	P01153	GSK3	SCHPO|PomBase=SPBC8D2.01|UniProtKB=Q9URT9	Protein kinase gsk31	ISS	11995474	gi	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00057	Wnt signaling pathway	P01471	alpha-catenin	PANTR|Ensembl=ENSPTRG00000017291|UniProtKB=H2QRK9	Catenin (Cadherin-associated protein), alpha 1, 102kDa	ISS	1904011	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-7595|UniProtKB=Q6PBR4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00056	VEGF signaling pathway	P01403	VEGFR-2	MACMU|Ensembl=ENSMMUG00000012669|UniProtKB=F7E313	Uncharacterized protein	ISS	11824379	PubMed	PTHR24416:SF45	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	RAT|RGD=2738|UniProtKB=Q00960	Glutamate receptor ionotropic, NMDA 2B	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	CHICK|Ensembl=ENSGALG00000008058|UniProtKB=F1N8W8	Uncharacterized protein	ISS	7559398	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00049	Parkinson disease	P01242	Casein kinase I	MOUSE|MGI=MGI=1920014|UniProtKB=Q8BVP5	Casein kinase I isoform gamma-2	IDA	11437445	PubMed	PTHR11909:SF157	CASEIN KINASE I ISOFORM GAMMA-2
P00057	Wnt signaling pathway	P01438	PP2A	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	12370081	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	GIAIC|EnsemblGenome=GL50803_3869|UniProtKB=E2RU39	Syntaxin 16	IC			PTHR19957:SF83	SYNTAXIN-16
P00005	Angiogenesis	P00203	Erk	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00010	B cell activation	P00375	Calmodulin	CANLF|Ensembl=ENSCAFG00000017516|UniProtKB=E2REK6	Uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF311	CALMODULIN
P00047	PDGF signaling pathway	P01142	p90RSK	ORNAN|Ensembl=ENSOANG00000010658|UniProtKB=F6V2V1	Uncharacterized protein	ISS	2779569	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DANRE|ZFIN=ZDB-GENE-030131-6503|UniProtKB=Q7ZUC5	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF297	PROTEIN KINASE C DELTA TYPE
P00017	DNA replication	P00527	Histones	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g231526|UniProtKB=A7T8N3	Histone H3	ISS	12413958	PubMed	PTHR11426:SF163	SUBFAMILY NOT NAMED
P02777	Succinate to proprionate conversion	P03161	Methylmalonyl-CoA mutase	MONDO|Ensembl=ENSMODG00000018855|UniProtKB=F7DW04	Uncharacterized protein	ISS			PTHR42710:SF1	METHYLMALONYL-COA MUTASE, MITOCHONDRIAL
P00010	B cell activation	P00375	Calmodulin	DICDI|dictyBase=DDB_G0279407|UniProtKB=P02599	Calmodulin	ISS			PTHR23050:SF245	AT16150P-RELATED
P00036	Interleukin signaling pathway	P00970	Interleukin	MOUSE|MGI=MGI=96561|UniProtKB=P10168	Interleukin-7	IDA	3259677	PubMed	PTHR45542:SF1	INTERLEUKIN-7
P00010	B cell activation	P00379	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00029	Huntington disease	P00778	NMDA receptor	CAEEL|WormBase=WBGene00003774|UniProtKB=G5EGQ9	NMDA class glutamate Receptor	IDA	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	PANTR|Ensembl=ENSPTRG00000004566|UniProtKB=H2Q597	Uncharacterized protein	ISS	193400	OMIM	PTHR11339:SF361	VON WILLEBRAND FACTOR-RELATED
P00005	Angiogenesis	P00182	p38MAPK	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	ISS	10995439	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00227	PLA2	BOVIN|Ensembl=ENSBTAG00000013298|UniProtKB=A4IFJ5	Cytosolic phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00057	Wnt signaling pathway	P01443	Phospholipase C	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00015	Circadian clock system	P00502	Casein kinase I	HUMAN|HGNC=2453|UniProtKB=P49674	Casein kinase I isoform epsilon	ISS	11865049	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00036	Interleukin signaling pathway	P00964	p90RSK	MACMU|Ensembl=ENSMMUG00000022111|UniProtKB=F7H7W3	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P05916	Opioid prodynorphin pathway	P06002	G-protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00091	Aph-1	PANTR|Ensembl=ENSPTRG00000007146|UniProtKB=H2Q9J9	Anterior pharynx defective 1 homolog B	ISS	12110170	PubMed	PTHR12889:SF1	GAMMA-SECRETASE SUBUNIT APH-1B
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IDA	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	EMENI|EnsemblGenome=CADANIAG00006296|UniProtKB=Q5ASG1	Putative synaptobrevin homologue SNC1/2 (Eurofung)	ISS			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P02788	Xanthine and guanine salvage pathway	P03249	Guanine deaminase	MOUSE|MGI=MGI=95678|UniProtKB=Q9R111	Guanine deaminase	ISS	11962625	PubMed	PTHR11271:SF6	GUANINE DEAMINASE
P00005	Angiogenesis	P00243	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	3449797	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00048	PI3 kinase pathway	P01182	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00020	FAS signaling pathway	P00615	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00750	Rhodopsin kinase	MOUSE|MGI=MGI=1345146|UniProtKB=Q9WVL4	Rhodopsin kinase	ISS	8260489	PubMed	PTHR24355:SF11	RHODOPSIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	CAEEL|WormBase=WBGene00000066|UniProtKB=P10986	Actin-4	ISS	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00005	Angiogenesis	P00243	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00029	Huntington disease	P00790	beta-Tubulin	CANLF|Ensembl=ENSCAFG00000018634|UniProtKB=E2RFV2	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF253	TUBULIN BETA-4A CHAIN
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00010	B cell activation	P00402	Jnk	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00648	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	IGI	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00059	p53 pathway	G04702	p53	DANRE|ZFIN=ZDB-GENE-990415-270|UniProtKB=P79734	Cellular tumor antigen p53	TAS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00327	FADD	RAT|RGD=628700|UniProtKB=Q8R2E7	FAS-associated death domain protein	ISS	9506948	PubMed	PTHR15077:SF8	FAS-ASSOCIATED DEATH DOMAIN PROTEIN
P00057	Wnt signaling pathway	P01465	Ggamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P02781	Threonine biosynthesis	P03190	Threonine synthase	HALSA|EnsemblGenome=VNG_0541G|UniProtKB=Q9HRU4	Threonine synthase	ISS			PTHR10314:SF5	THREONINE SYNTHASE 1, CHLOROPLASTIC
P00053	T cell activation	P01312	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	MACMU|Ensembl=ENSMMUG00000019999|UniProtKB=F7FNE2	Uncharacterized protein	ISS	11443533	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00034	Integrin signalling pathway	P00923	Arf1	PANTR|Ensembl=ENSPTRG00000005350|UniProtKB=H2Q6P9	ADP-ribosylation factor-like 1	ISS	11752622	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04371	5-Hydroxytryptamine biosynthesis	P04399	Tryptophan hydroxylase	CAEEL|WormBase=WBGene00006600|UniProtKB=G5EED8	TryPtophan Hydroxylase	ISS	14597720	PubMed	PTHR11473:SF16	TRYPTOPHAN 5-HYDROXYLASE 2
P00018	EGF receptor signaling pathway	P00562	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00010	B cell activation	P00384	p38	RAT|RGD=1309340|UniProtKB=D4A3U7	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00010	B cell activation	P00375	Calmodulin	BRAFL|Gene=BRAFLDRAFT_87235|UniProtKB=C3ZEV9	Putative uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00036	Interleukin signaling pathway	P00981	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IDA	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	PANTR|Ensembl=ENSPTRG00000022214|UniProtKB=H2QZ14	Uncharacterized protein	ISS	12223527	PubMed	PTHR23036:SF89	INTERLEUKIN-13 RECEPTOR SUBUNIT ALPHA-1
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	ISS	http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P02759	Pyridoxal-5-phosphate biosynthesis	P03058	Phosphohydroxythreonine aminotransferase	STRCO|Gene=CAC08322|UniProtKB=Q9F2Y1	Phosphoserine aminotransferase	ISS			PTHR21152:SF24	SUBFAMILY NOT NAMED
P02776	Serine glycine biosynthesis	P03157	Phosphoserine aminotransferase	BOVIN|Ensembl=ENSBTAG00000013960|UniProtKB=A6QR28	Phosphoserine aminotransferase	ISS	20886743	gi	PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P00020	FAS signaling pathway	P00604	Pro-Caspase8	PANTR|Ensembl=ENSPTRG00000012801|UniProtKB=H2QJ86	Caspase 8, apoptosis-related cysteine peptidase	ISS	11788820	PubMed	PTHR10454:SF162	CASPASE-8
P05731	GABA-B receptor II signaling	P05752	PKA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	RCA	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00897	SHIP2	BOVIN|Ensembl=ENSBTAG00000019167|UniProtKB=E1BBJ7	Uncharacterized protein	ISS	10610720	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00048	PI3 kinase pathway	P01188	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CANLF|Ensembl=ENSCAFG00000018564|UniProtKB=E2RHU1	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	RAT|RGD=61862|UniProtKB=P19491	Glutamate receptor 2	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IDA	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00627	ERK1-2	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	NAS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P05731	GABA-B receptor II signaling	P05754	Ggamma	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	RCA	3100519	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00049	Parkinson disease	P01236	Casein kinase II	PANTR|Ensembl=ENSPTRG00000017974|UniProtKB=H2QSN4	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	RAT|RGD=1304749|UniProtKB=A0A0G2K0H3	Protein Lrp6	ISS	11907044	PubMed	PTHR44017:SF3	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00019	Endothelin signaling pathway	P00566	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	20216076	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00030	Hypoxia response via HIF activation	P00819	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	HUMAN|HGNC=4573|UniProtKB=P42263	Glutamate receptor 3	ISS	12941441	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00009	Axon guidance mediated by netrin	P00366	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	20010089	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	RAT|RGD=621789|UniProtKB=P70539	Activin receptor type-1C	TAS	9395284	PubMed	PTHR23255:SF58	ACTIVIN RECEPTOR TYPE-1C
P00036	Interleukin signaling pathway	P00970	Interleukin	MACMU|Ensembl=ENSMMUG00000007403|UniProtKB=F6T3G5	Uncharacterized protein	ISS			PTHR44866:SF1	INTERLEUKIN-17A
P00029	Huntington disease	P00795	BDNF	HUMAN|HGNC=1033|UniProtKB=P23560	Brain-derived neurotrophic factor	ISS	11724916	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00853	Integrin	RAT|RGD=2927|UniProtKB=P49134	Integrin beta-1	ISS	3487386	PubMed	PTHR10082:SF28	INTEGRIN BETA-1
P00057	Wnt signaling pathway	P01435	SWI/SNF	MONDO|Ensembl=ENSMODG00000004451|UniProtKB=F6R7T1	Uncharacterized protein	ISS	11532957	PubMed	PTHR13844:SF5	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D MEMBER 3
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MACMU|Ensembl=ENSMMUG00000022808|UniProtKB=F6UWC3	Actin-related protein 2/3 complex subunit 2	ISS	12473693	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00034	Integrin signalling pathway	P00922	Collagen	BOVIN|Ensembl=ENSBTAG00000007602|UniProtKB=E1BNM2	Uncharacterized protein	ISS			PTHR23220:SF5	INTEGRIN ALPHA-8
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=3036262|UniProtKB=Q3USB7	Inactive phospholipase C-like protein 1	ISS			PTHR10336:SF102	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1
P00018	EGF receptor signaling pathway	P00558	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00052	TGF-beta signaling pathway	P01284	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01451	Galpha	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00047	PDGF signaling pathway	P01171	PLCgamma	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	11976687	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04393	Ras Pathway	P04555	PDK	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	IDA	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00006	Apoptosis signaling pathway	P00268	GCK	BOVIN|Ensembl=ENSBTAG00000001037|UniProtKB=E1B902	Mitogen-activated protein kinase kinase kinase kinase	ISS			PTHR24361:SF392	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 2
P00007	Axon guidance mediated by semaphorins	P00340	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	8649368	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TRIVA|Gene=TVAG_337240|UniProtKB=P90623	Actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00019	Endothelin signaling pathway	P00589	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04371	5-Hydroxytryptamine biosynthesis	P04400	Aromatic L-amino acid decarboxylase	CAEEL|WormBase=WBGene00001839|UniProtKB=P34751	Probable aromatic-L-amino-acid decarboxylase	ISS	90339966	PubMed	PTHR11999:SF59	AROMATIC-L-AMINO-ACID DECARBOXYLASE-RELATED
P00034	Integrin signalling pathway	P00951	Jnk	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00029	Huntington disease	P00795	BDNF	PANTR|Ensembl=ENSPTRG00000028696|UniProtKB=Q5IS78	Brain-derived neurotrophic factor	ISS	12117585	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00059	p53 pathway	P04609	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01471	alpha-catenin	BOVIN|Ensembl=ENSBTAG00000004997|UniProtKB=E1BBP2	Uncharacterized protein	ISS	9362521	PubMed	PTHR18914:SF8	ALPHA-CATULIN
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	RCA	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MOUSE|MGI=MGI=109164|UniProtKB=Q80SZ7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	10391901	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02746	Heme biosynthesis	P02979	porphobilinogen synthase	DROME|FlyBase=FBgn0036271|UniProtKB=Q9VTV9	Delta-aminolevulinic acid dehydratase	ISS			PTHR11458:SF0	DELTA-AMINOLEVULINIC ACID DEHYDRATASE
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00017	DNA replication	P00527	Histones	CHLRE|EnsemblGenome=CHLREDRAFT_155704|UniProtKB=A8HWY2	Histone H3 (Fragment)	ISS	12413958	PubMed	PTHR11426:SF169	HISTONE H3
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MACMU|Gene=CHRM1|UniProtKB=P56489	Muscarinic acetylcholine receptor M1	TAS	12915051	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	BRAFL|Gene=BRAFLDRAFT_271417|UniProtKB=C3ZCG7	Protein Wnt	TAS	8717036	PubMed	PTHR12027:SF102	PROTEIN WNT-4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01179	PKB	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00648	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00021	FGF signaling pathway	P00628	JNK1-3	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00009	Axon guidance mediated by netrin	P00366	Rac	PANTR|Ensembl=ENSPTRG00000018910|UniProtKB=H2R207	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00005	Angiogenesis	P00254	GTPase	YEAST|SGD=S000006369|UniProtKB=P06780	GTP-binding protein RHO1	ISS			PTHR24072:SF168	RAS-LIKE GTP-BINDING PROTEIN RHO1
P00010	B cell activation	P00402	Jnk	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04392	P53 pathway feedback loops 1	P04539	p53	CANLF|Gene=TP53|UniProtKB=Q29537	Cellular tumor antigen p53	TAS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00034	Integrin signalling pathway	P00924	Raf	MACMU|Ensembl=ENSMMUG00000011418|UniProtKB=F6VS08	Uncharacterized protein	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DROME|FlyBase=FBgn0003091|UniProtKB=P05130	Protein kinase C, brain isozyme	ISS	3045562	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00004	Alzheimer disease-presenilin pathway	P00172	BACE-1	HUMAN|HGNC=933|UniProtKB=P56817	Beta-secretase 1	IDA	10531052	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00057	Wnt signaling pathway	P01432	Beta-Catenin	STRPU|EnsemblGenome=SPU_009155|UniProtKB=W4Y0D3	Uncharacterized protein	ISS			PTHR23315:SF233	ARMADILLO SEGMENT POLARITY PROTEIN
P00018	EGF receptor signaling pathway	P00544	c-Cbl	MACMU|Ensembl=ENSMMUG00000007565|UniProtKB=F6T053	Uncharacterized protein	ISS	95303504	PubMed	PTHR23007:SF3	E3 UBIQUITIN-PROTEIN LIGASE CBL-B
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00047	PDGF signaling pathway	P01167	Ets	HUMAN|HGNC=3749|UniProtKB=Q01543	Friend leukemia integration 1 transcription factor	ISS	15298723	PubMed	PTHR11849:SF161	FRIEND LEUKEMIA INTEGRATION 1 TRANSCRIPTION FACTOR
P00019	Endothelin signaling pathway	P00591	PLCbeta	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MONDO|Ensembl=ENSMODG00000011428|UniProtKB=F6RKF7	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF34	FRIZZLED-2
P00056	VEGF signaling pathway	P01417	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00060	Ubiquitin proteasome pathway	P01494	19S proteasome	PHYPA|Gene=PHYPADRAFT_121533|UniProtKB=A9RYX6	Predicted protein	ISS			PTHR23073:SF8	26S PROTEASE REGULATORY SUBUNIT 6B
P00048	PI3 kinase pathway	P01177	P110ACT	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01145	c-fos	PANTR|Ensembl=ENSPTRG00000006553|UniProtKB=A5A6H0	C-fos	ISS	11402335	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00048	PI3 kinase pathway	P01177	P110ACT	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00367	NFAT	HUMAN|HGNC=7776|UniProtKB=Q13469	Nuclear factor of activated T-cells, cytoplasmic 2	IDA	12787506	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	12707323	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P05913	Enkephalin release	P05974	G-Protein (i)	MACMU|Ensembl=ENSMMUG00000019900|UniProtKB=F7GQC3	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=1309999|UniProtKB=Q922R0	cAMP-dependent protein kinase catalytic subunit PRKX	IC	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00057	Wnt signaling pathway	P01444	Wnt	BOVIN|Ensembl=ENSBTAG00000014291|UniProtKB=A6H6X8	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00018	EGF receptor signaling pathway	P00547	PP2A	BRAFL|Gene=BRAFLDRAFT_123893|UniProtKB=C3XQF4	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00020	FAS signaling pathway	P00615	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00010	B cell activation	P00373	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	SCHPO|PomBase=SPBC8D2.01|UniProtKB=Q9URT9	Protein kinase gsk31	ISS	12615961	PubMed	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00010	B cell activation	P00398	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05916	Opioid prodynorphin pathway	G06047	preprodynorphin	MACMU|Ensembl=ENSMMUG00000009984|UniProtKB=F6R267	Beta-neoendorphin-dynorphin	ISS	131330	OMIM	PTHR11438:SF4	PROENKEPHALIN-B
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	PSEAE|EnsemblGenome=PA2104|UniProtKB=Q9I211	Probable cysteine synthase	ISS			PTHR10314:SF100	CYSTEINE SYNTHASE B
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	ISS	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000008751|UniProtKB=H2QC89	Uncharacterized protein	ISS	129387	gi	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00047	PDGF signaling pathway	P01162	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00036	Interleukin signaling pathway	P00968	Ikk	MOUSE|MGI=MGI=99484|UniProtKB=Q60680	Inhibitor of nuclear factor kappa-B kinase subunit alpha	ISS	14499113	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00947	Laminin	HUMAN|HGNC=6481|UniProtKB=P25391	Laminin subunit alpha-1	IPI	2538453	PubMed	PTHR10574:SF299	LAMININ SUBUNIT ALPHA-1
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	HUMAN|HGNC=4579|UniProtKB=P39086	Glutamate receptor ionotropic, kainate 1	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000000931|UniProtKB=H2PZC4	Protein kinase N2	ISS	11880265	PubMed	PTHR24356:SF301	SERINE/THREONINE-PROTEIN KINASE N2
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00912	Arp2/3	BOVIN|Ensembl=ENSBTAG00000015278|UniProtKB=Q5E963	Actin-related protein 2/3 complex subunit 5-like protein	ISS	12932731	PubMed	PTHR12644:SF2	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5-LIKE PROTEIN
P00023	General transcription regulation	P00668	TFIIB	CHICK|Ensembl=ENSGALG00000000898|UniProtKB=Q5ZHP3	Cilia- and flagella-associated protein 20	ISS			PTHR12458:SF8	CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20
P00029	Huntington disease	P00790	beta-Tubulin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g167737|UniProtKB=A7S8I3	Predicted protein	ISS			PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00010	B cell activation	P00373	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	YEAST|SGD=S000004747|UniProtKB=P38615	Serine/threonine-protein kinase RIM11/MSD1	IDA	21361340	gi	PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DICPU|Gene=DICPUDRAFT_46519|UniProtKB=F0Z796	Putative uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IDA	10669416	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00012	Cadherin signaling pathway	P00474	Wnt	BOVIN|Ensembl=ENSBTAG00000020267|UniProtKB=F1MKX1	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g239961|UniProtKB=A7RQF7	Predicted protein	ISS			PTHR10410:SF5	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 14
P05918	p38 MAPK pathway	P06019	ATF1	MACMU|Ensembl=ENSMMUG00000012095|UniProtKB=F7HB38	Cyclic AMP-dependent transcription factor ATF-1	ISS	11390664	PubMed	PTHR22952:SF258	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-1
P00018	EGF receptor signaling pathway	P00544	c-Cbl	BOVIN|Ensembl=ENSBTAG00000006817|UniProtKB=E1BJS3	Uncharacterized protein	ISS	4885117	gi	PTHR23007:SF5	E3 UBIQUITIN-PROTEIN LIGASE CBL
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	HUMAN|HGNC=20637|UniProtKB=Q9BPU6	Dihydropyrimidinase-related protein 5	IPI	11034345	PubMed	PTHR11647:SF58	DIHYDROPYRIMIDINASE-RELATED PROTEIN 5
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	MONDO|Ensembl=ENSMODG00000015970|UniProtKB=F7FD05	Uncharacterized protein	ISS	11390664	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	HUMAN|HGNC=11438|UniProtKB=Q13277	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00005	Angiogenesis	P00193	SOS-1	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	SULSO|EnsemblGenome=SSO0495|UniProtKB=Q97ZT3	Pyrroline-5-carboxylate reductase	ISS			PTHR11645:SF0	PYRROLINE-5-CARBOXYLATE REDUCTASE
P00018	EGF receptor signaling pathway	P00539	14-3-3	XENTR|Xenbase=XB-GENE-1006026|UniProtKB=Q5XGC8	14-3-3 protein beta/alpha	ISS	10407019	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000006495|UniProtKB=P11017	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00058	mRNA splicing	P01474	U5	MOUSE|MGI=MGI=1913835|UniProtKB=Q6PE01	U5 small nuclear ribonucleoprotein 40 kDa protein	ISS	9774689	PubMed	PTHR44006:SF1	U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	IC	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	ARATH|TAIR=AT1G13890|UniProtKB=Q9LMG8	Putative SNAP25 homologous protein SNAP30	IC			PTHR19305:SF7	SNAP25 HOMOLOGOUS PROTEIN SNAP30-RELATED
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	RAT|RGD=3188|UniProtKB=Q9QW30	Neurogenic locus notch homolog protein 2	IDA	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00025	Hedgehog signaling pathway	P00682	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CAEEL|WormBase=WBGene00000067|UniProtKB=O45815	ACTin	IDA	14684598	PubMed	PTHR11937:SF352	ACTIN
P00005	Angiogenesis	P00252	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8316835	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	IC	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00029	Huntington disease	P00801	Fos protein	XENTR|Xenbase=XB-GENE-866811|UniProtKB=F7EI91	Uncharacterized protein (Fragment)	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	RAT|RGD=621347|UniProtKB=P70569	Unconventional myosin-Vb	IC			PTHR13140:SF356	UNCONVENTIONAL MYOSIN-VB
P00006	Apoptosis signaling pathway	P00310	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06959	CCKR signaling map	G06969	HDC	HUMAN|HGNC=4855|UniProtKB=P19113	Histidine decarboxylase	RCA	12372397	PubMed	PTHR11999:SF68	HISTIDINE DECARBOXYLASE
P00005	Angiogenesis	P00190	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	2574500	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00036	Interleukin signaling pathway	P00996	STAT	DANRE|ZFIN=ZDB-GENE-980526-499|UniProtKB=Q6P943	Signal transducer and activator of transcription	IDA	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00034	Integrin signalling pathway	P00951	Jnk	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IDA	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	CHICK|Ensembl=ENSGALG00000009320|UniProtKB=Q4JIM4	Presenilin-1	TAS	12834808	PubMed	PTHR10202:SF18	PRESENILIN-1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	HUMAN|HGNC=7577|UniProtKB=P12883	Myosin-7	IEP	10938134	PubMed	PTHR13140:SF344	MYOSIN-7
P00036	Interleukin signaling pathway	P00962	ELK	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	9644975	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00019	Endothelin signaling pathway	P00591	PLCbeta	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05731	GABA-B receptor II signaling	P05752	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IDA	98060792	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00006	Apoptosis signaling pathway	P00266	SEK1	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	10207617	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P02774	Salvage pyrimidine deoxyribonucleotides	P03148	Thymidine phosphorylase	MYCTU|EnsemblGenome=Rv3314c|UniProtKB=P9WFS1	Thymidine phosphorylase	ISS			PTHR10515:SF0	THYMIDINE PHOSPHORYLASE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02763	Peptidoglycan biosynthesis	P03084	UDP-N-acetylmuramoylalanyl-D-glutamate 2,6-diaminopimelate ligase	BACTN|EnsemblGenome=BT_3452|UniProtKB=Q8A254	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase	ISS			PTHR23135:SF4	UDP-N-ACETYLMUAMOYLALANYL-D-GLUTAMATE-2,6-DIAMINOPIMELATE LIGASE-RELATED
P00004	Alzheimer disease-presenilin pathway	P00168	E-cadherin intracellular fragment	RAT|RGD=621089|UniProtKB=F1LMI3	Cadherin 3, type 1, P-cadherin (Placental)	ISS	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P06664	Gonadotropin-releasing hormone receptor pathway	P06782	PKA	MOUSE|MGI=MGI=97759|UniProtKB=P12849	cAMP-dependent protein kinase type I-beta regulatory subunit	RCA	188830	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IDA	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00048	PI3 kinase pathway	P01205	NOS	CANLF|Gene=NOS2|UniProtKB=O62699	Nitric oxide synthase, inducible	ISS			PTHR19384:SF56	NITRIC OXIDE SYNTHASE, INDUCIBLE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	SCLS1|EnsemblGenome=SS1G_12241|UniProtKB=A7F2U3	Casein kinase II	ISS	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P04393	Ras Pathway	P04553	PAK	HUMAN|HGNC=8590|UniProtKB=Q13153	Serine/threonine-protein kinase PAK 1	IDA	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IDA	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00014	Cholesterol biosynthesis	P00491	Hydroxymethyl glutaryl CoA reductase	STRPU|EnsemblGenome=SPU_005963|UniProtKB=W4XRC0	3-hydroxy-3-methylglutaryl coenzyme A reductase	TAS	P16393	SPACC	PTHR10572:SF2	3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MONDO|Ensembl=ENSMODG00000008900|UniProtKB=F7B4C1	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P02788	Xanthine and guanine salvage pathway	P03247	Xanthine phosphoribosyl transferase	HUMAN|HGNC=23333|UniProtKB=Q9NRG1	Phosphoribosyltransferase domain-containing protein 1	ISS			PTHR43340:SF5	PHOSPHORIBOSYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1
P00003	Alzheimer disease-amyloid secretase pathway	P00108	ADAM10	MOUSE|MGI=MGI=109548|UniProtKB=O35598	Disintegrin and metalloproteinase domain-containing protein 10	IDA	10097139	PubMed	PTHR11905:SF4	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 10
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	IC	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04665	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04393	Ras Pathway	P04559	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	4757952	gi	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P05913	Enkephalin release	P05977	G-Protein (s)	MONDO|Ensembl=ENSMODG00000016595|UniProtKB=F6ZDB2	Uncharacterized protein	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P05916	Opioid prodynorphin pathway	P06002	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00091	Aph-1	MONDO|Ensembl=ENSMODG00000018778|UniProtKB=F7ADK5	Uncharacterized protein	ISS	12110170	PubMed	PTHR12889:SF3	GAMMA-SECRETASE SUBUNIT APH-1A
P02723	Adenine and hypoxanthine salvage pathway	P02807	Deoxyadenosine deaminase	DROME|FlyBase=FBgn0037661|UniProtKB=Q9VHH7	Adenosine deaminase-like protein	ISS			PTHR11409:SF42	ADENOSINE DEAMINASE-LIKE PROTEIN
P00034	Integrin signalling pathway	P00918	Caveolin	CANLF|Ensembl=ENSCAFG00000003404|UniProtKB=P33724	Caveolin-1	IPI	9741627	PubMed	PTHR10844:SF18	CAVEOLIN-1
P00023	General transcription regulation	P00658	TBP-associated factors	SCHPO|PomBase=SPCC1259.06|UniProtKB=O94706	Transcription initiation factor TFIID subunit 8	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00059	p53 pathway	P04633	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00054	Toll receptor signaling pathway	P01369	MKK1	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8440264	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00544	c-Cbl	MACMU|Ensembl=ENSMMUG00000004761|UniProtKB=F6SMS3	E3 ubiquitin-protein ligase CBL	ISS	4885117	gi	PTHR23007:SF5	E3 UBIQUITIN-PROTEIN LIGASE CBL
P00034	Integrin signalling pathway	P00917	ELMO	CHICK|Ensembl=ENSGALG00000007246|UniProtKB=E1C122	Uncharacterized protein	ISS	12879077	PubMed	PTHR12771:SF8	ENGULFMENT AND CELL MOTILITY PROTEIN 2
P00005	Angiogenesis	P00237	FRP	BOVIN|Ensembl=ENSBTAG00000035084|UniProtKB=F1MLG5	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF22	FRIZZLED-3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05913	Enkephalin release	P05974	G-Protein (i)	XENTR|Xenbase=XB-GENE-956713|UniProtKB=Q5XGD8	Guanine nucleotide binding protein, beta 3	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00010	B cell activation	P00384	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00012	Cadherin signaling pathway	P00470	F-actin	MONBE|Gene=37852|UniProtKB=A9V489	Predicted protein	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	RAT|RGD=71043|UniProtKB=Q8CFN2	Cell division control protein 42 homolog	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00048	PI3 kinase pathway	P01179	PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P06587	Nicotine pharmacodynamics pathway	P06612	CHRNB3	MOUSE|MGI=MGI=106212|UniProtKB=Q8BMN3	Neuronal acetylcholine receptor subunit beta-3	ISS	85270494	PubMed	PTHR18945:SF75	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-3
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	CANLF|Ensembl=ENSCAFG00000010476|UniProtKB=F1PS94	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	10799299	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00009	Axon guidance mediated by netrin	P00366	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12805548	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00566	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	8946911	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00060	Ubiquitin proteasome pathway	P01491	E2	PHYPA|Gene=PHYPADRAFT_228283|UniProtKB=A9U4R7	Predicted protein	ISS			PTHR24068:SF47	SUMO-CONJUGATING ENZYME UBC9-RELATED
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	DROME|FlyBase=FBgn0025743|UniProtKB=Q9VXE5	Serine/threonine-protein kinase PAK mbt	ISS			PTHR24361:SF345	SERINE/THREONINE-PROTEIN KINASE PAK 4
P04374	5HT2 type receptor mediated signaling pathway	P04417	5HT transporter	HUMAN|HGNC=11050|UniProtKB=P31645	Sodium-dependent serotonin transporter	ISS	14653308	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05916	Opioid prodynorphin pathway	P06002	G-protein	MACMU|Ensembl=ENSMMUG00000017374|UniProtKB=F7H6T7	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04393	Ras Pathway	P04557	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	BOVIN|Ensembl=ENSBTAG00000020907|UniProtKB=E1BEL5	Uncharacterized protein	ISS			PTHR15938:SF0	HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00475	Frizzled	XENTR|Xenbase=XB-GENE-480379|UniProtKB=Q6GL20	Frizzled homolog 10	ISS	8717036	PubMed	PTHR11309:SF86	FRIZZLED-10
P00034	Integrin signalling pathway	P00942	Fyn	CANLF|Ensembl=ENSCAFG00000003995|UniProtKB=E2RC09	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	11535291	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00017	DNA replication	P00527	Histones	MACMU|Ensembl=ENSMMUG00000031349|UniProtKB=H9H5A2	Histone H3	ISS	20448842	PubMed	PTHR11426:SF169	HISTONE H3
P02784	Tyrosine biosynthesis	P03213	Aromatic amino acid aminotransferase	ECOLI|EcoGene=EG11040|UniProtKB=P04693	Aromatic-amino-acid aminotransferase	ISS			PTHR11879:SF10	ASPARTATE AMINOTRANSFERASE
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	RAT|RGD=619966|UniProtKB=F1LQT1	Adenylate cyclase 7	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	125549	gi	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00048	PI3 kinase pathway	P01177	P110ACT	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00539	14-3-3	DANRE|ZFIN=ZDB-GENE-011115-1|UniProtKB=Q6PC29	14-3-3 protein gamma-1	ISS	8381897	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IC	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00780	Microtubule	ARATH|TAIR=AT5G23860|UniProtKB=P29516	Tubulin beta-8 chain	IDA	9454836	PubMed	PTHR11588:SF264	TUBULIN BETA-8 CHAIN
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	BOVIN|Ensembl=ENSBTAG00000003762|UniProtKB=A5PJS1	GNB5 protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00056	VEGF signaling pathway	P01408	Akt/PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BRAFL|Gene=BRAFLDRAFT_127488|UniProtKB=C3XYC7	Putative uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	MOUSE|MGI=MGI=106217|UniProtKB=Q61290	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	14507926	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IPI	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00005	Angiogenesis	P00243	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02777	Succinate to proprionate conversion	P03163	Methylmalonyl-CoA decarboxylase	THEMA|EnsemblGenome=TM_0716|UniProtKB=Q9WZH5	Acetyl-coenzyme A carboxyl transferase alpha chain / Acetyl-coenzyme A carboxyl transferase beta chain Propionyl-CoA carboxylase beta chain	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P00037	Ionotropic glutamate receptor pathway	P01026	KA	BOVIN|Ensembl=ENSBTAG00000033153|UniProtKB=F1MG21	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00057	Wnt signaling pathway	P01443	Phospholipase C	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2847|UniProtKB=P28565	5-hydroxytryptamine receptor 1D	IDA	12181435	PubMed	PTHR24247:SF17	5-HYDROXYTRYPTAMINE RECEPTOR 1D
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	IC	15737619	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	PANTR|Ensembl=ENSPTRG00000010253|UniProtKB=H2QEX9	Uncharacterized protein	ISS	9783586	PubMed	PTHR10814:SF4	AMINO-TERMINAL ENHANCER OF SPLIT-RELATED
P00054	Toll receptor signaling pathway	P01369	MKK1	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00052	TGF-beta signaling pathway	P01284	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00214	HIF-1	HUMAN|HGNC=4910|UniProtKB=Q16665	Hypoxia-inducible factor 1-alpha	IGI	9606183	PubMed	PTHR23043:SF7	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	HUMAN|HGNC=8925|UniProtKB=P46020	Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform	IDA	10487978	PubMed	PTHR10749:SF4	PHOSPHORYLASE B KINASE REGULATORY SUBUNIT ALPHA, SKELETAL MUSCLE ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00514	MLCK	PANTR|Ensembl=ENSPTRG00000015307|UniProtKB=H2R459	Uncharacterized protein	ISS	11157482	PubMed	PTHR45480:SF1	MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE
P06959	CCKR signaling map	P07170	TAK1	HUMAN|HGNC=7972|UniProtKB=P49116	Nuclear receptor subfamily 2 group C member 2	RCA	10094049	PubMed	PTHR24083:SF48	NUCLEAR RECEPTOR SUBFAMILY 2 GROUP C MEMBER 2
P00059	p53 pathway	P04609	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	10799299	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	MACMU|Ensembl=ENSMMUG00000003949|UniProtKB=F6ZMA8	Uncharacterized protein	ISS			PTHR18945:SF768	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-10
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	MACMU|Ensembl=ENSMMUG00000015916|UniProtKB=F7AT89	Uncharacterized protein	ISS	17597586	PubMed	PTHR18945:SF401	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4
P05916	Opioid prodynorphin pathway	P06002	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00010	B cell activation	P00391	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00627	ERK1-2	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	PSEAE|EnsemblGenome=PA5522|UniProtKB=Q9HT51	Probable glutamine synthetase	ISS			PTHR43785:SF1	TYPE-1 GLUTAMINE SYNTHETASE 2
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P02787	Vitamin B6 metabolism	P03244	Pyridoxal kinase	PANTR|Ensembl=ENSPTRG00000040962|UniProtKB=H2RGH3	Pyridoxal (Pyridoxine, vitamin B6) kinase	ISS	9099727	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P00036	Interleukin signaling pathway	P00990	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	HUMAN|HGNC=4580|UniProtKB=Q13002	Glutamate receptor ionotropic, kainate 2	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00005	Angiogenesis	P00203	Erk	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00023	General transcription regulation	P00670	TBP	XENTR|Xenbase=XB-GENE-488460|UniProtKB=Q6DIY4	TATA box-binding protein-like protein 1	ISS	10470030	PubMed	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00018	EGF receptor signaling pathway	P00557	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00029	Huntington disease	P00807	Actin	CAEBR|Gene=CBG23090|UniProtKB=A8Y4R0	Protein CBG23090	ISS	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P06587	Nicotine pharmacodynamics pathway	P06611	CLIC6	MACMU|Ensembl=ENSMMUG00000004605|UniProtKB=F6Q8V4	Chloride intracellular channel protein	ISS	14499480	PubMed	PTHR45476:SF1	CHLORIDE INTRACELLULAR CHANNEL PROTEIN 6
P02738	De novo purine biosynthesis	P02890	Adenylosuccinate synthase	STRCO|EnsemblGenome=CAB42016|UniProtKB=Q9X8P6	Adenylosuccinate synthetase	ISS	10636885	PubMed	PTHR11846:SF0	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DANRE|ZFIN=ZDB-GENE-041210-195|UniProtKB=F1R506	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P02738	De novo purine biosynthesis	P02908	Phosphoribosylamine glycine ligase	TAKRU|Ensembl=ENSTRUG00000013234|UniProtKB=H2U9R9	Uncharacterized protein	ISS			PTHR10520:SF10	TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3
P00024	Glycolysis	P00674	Phosphoglucose isomerase	STRCO|EnsemblGenome=CAA19938|UniProtKB=O88015	Glucose-6-phosphate isomerase 1	ISS	21996410	PubMed	PTHR11469:SF1	GLUCOSE-6-PHOSPHATE ISOMERASE, CYTOSOLIC
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8971|UniProtKB=O00443	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	G04712	P21	HUMAN|HGNC=1784|UniProtKB=P38936	Cyclin-dependent kinase inhibitor 1	ISS			PTHR10265:SF16	CYCLIN-DEPENDENT KINASE INHIBITOR 1
P00006	Apoptosis signaling pathway	P00274	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	IC	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	86289426	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00057	Wnt signaling pathway	P01444	Wnt	BOVIN|Ensembl=ENSBTAG00000022671|UniProtKB=F1MZV4	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04393	Ras Pathway	P04546	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00001	Adrenaline and noradrenaline biosynthesis	P00064	NET	CANLF|Ensembl=ENSCAFG00000009395|UniProtKB=B6F0U1	Transporter	ISS	97248649	PubMed	PTHR11616:SF37	SODIUM-DEPENDENT NORADRENALINE TRANSPORTER
P00018	EGF receptor signaling pathway	P00547	PP2A	MONDO|Ensembl=ENSMODG00000019001|UniProtKB=F7CP86	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	HUMAN|HGNC=6854|UniProtKB=Q9Y2U5	Mitogen-activated protein kinase kinase kinase 2	NAS	8621389	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00585	ECE1-3	MOUSE|MGI=MGI=1101356|UniProtKB=Q80Z60	Endothelin-converting enzyme 2	ISS			PTHR11733:SF127	ENDOTHELIN-CONVERTING ENZYME 2
P05731	GABA-B receptor II signaling	P05755	Gbeta	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	PANTR|Ensembl=ENSPTRG00000022026|UniProtKB=H2QYT1	Uncharacterized protein	ISS	9865691	PubMed	PTHR17045:SF6	CBP/P300-INTERACTING TRANSACTIVATOR 1
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05731	GABA-B receptor II signaling	P05758	K channel	MOUSE|MGI=MGI=104742|UniProtKB=P63250	G protein-activated inward rectifier potassium channel 1	RCA	2433589	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P02785	Valine biosynthesis	P03215	Branched chain amino acid aminotransferase	PSEAE|EnsemblGenome=PA5013|UniProtKB=O86428	Branched-chain-amino-acid aminotransferase	ISS			PTHR42743:SF3	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE-LIKE PROTEIN 1-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000008826|UniProtKB=F6XUU0	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P00020	FAS signaling pathway	P00608	Pro-Caspase3	RAT|RGD=2275|UniProtKB=P55213	Caspase-3	IGI	11675509	PubMed	PTHR10454:SF198	CASPASE-3
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	CHICK|Ensembl=ENSGALG00000015835|UniProtKB=F1NZT2	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	DROME|FlyBase=FBgn0010399|UniProtKB=Q24418	Glutamate [NMDA] receptor subunit 1	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CANLF|Ensembl=ENSCAFG00000003333|UniProtKB=F1PWT6	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P05916	Opioid prodynorphin pathway	P06002	G-protein	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	1411546	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	ISS	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	XENTR|Xenbase=XB-GENE-945015|UniProtKB=F6QA46	Uncharacterized protein	RCA			PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P00060	Ubiquitin proteasome pathway	P01491	E2	YEAST|SGD=S000002584|UniProtKB=P21734	Ubiquitin-conjugating enzyme E2 1	ISS			PTHR44020:SF2	UBIQUITIN-CONJUGATING ENZYME E2 K
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	ISS	10514528	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00049	Parkinson disease	P01230	Src kinase	HUMAN|HGNC=6735|UniProtKB=P07948	Tyrosine-protein kinase Lyn	IDA	11078745	PubMed	PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P00030	Hypoxia response via HIF activation	P00823	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00029	Huntington disease	P00810	GAPDH	TRIVA|Gene=TVAG_475220|UniProtKB=A2EM29	Glyceraldehyde-3-phosphate dehydrogenase	IPI			PTHR43148:SF2	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE C-RELATED
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	HUMAN|HGNC=1389|UniProtKB=Q00975	Voltage-dependent N-type calcium channel subunit alpha-1B	TAS	15079861	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00053	T cell activation	P01294	NFAT	BOVIN|Ensembl=ENSBTAG00000018270|UniProtKB=F1MGR9	Uncharacterized protein	ISS	12787506	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00057	Wnt signaling pathway	P01464	Pygo	HUMAN|HGNC=30257|UniProtKB=Q9BRQ0	Pygopus homolog 2	IDA	11955446	PubMed	PTHR23194:SF7	PYGOPUS HOMOLOG 2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	TAS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00005	Angiogenesis	P00249	PAK	MACMU|Ensembl=ENSMMUG00000001387|UniProtKB=F7D0B4	Uncharacterized protein	ISS	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00049	Parkinson disease	P01236	Casein kinase II	YARLI|EnsemblGenome=YALI0_D16863g|UniProtKB=Q6C8U8	YALI0D16863p	IDA	10806215	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00585	ECE1-3	MOUSE|MGI=MGI=1101357|UniProtKB=Q4PZA2	Endothelin-converting enzyme 1	ISS	96192242	PubMed	PTHR11733:SF130	ENDOTHELIN-CONVERTING ENZYME 1
P00036	Interleukin signaling pathway	P00990	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	RAT|RGD=3246|UniProtKB=Q63415	Proprotein convertase subtilisin/kexin type 6	IDA			PTHR42884:SF8	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 6
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=621025|UniProtKB=Q62711	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	12860966	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	3755548	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00547	PP2A	RAT|RGD=3381|UniProtKB=P62716	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	12370081	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00141	Membrane metalloprotease	RAT|RGD=1308937|UniProtKB=D3ZCG5	Protein Mmp15	ISS	12834808	PubMed	PTHR10201:SF25	MATRIX METALLOPROTEINASE-15
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01292	RSmads	CAEEL|WormBase=WBGene00004856|UniProtKB=Q02330	Dwarfin sma-2	TAS	9395284	PubMed	PTHR13703:SF40	PROTEIN MOTHERS AGAINST DPP
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	ISS	3755548	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00034	Integrin signalling pathway	P00920	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	8493579	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	RCA	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01212	p38 MAPK	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	NAS	20451058	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=103077|UniProtKB=Q64704	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00589	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IGI	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00021	FGF signaling pathway	P00642	MEK1-2	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02726	Aminobutyrate degradation	P02825	4-aminobutyrate aminotransferase	CANLF|Ensembl=ENSCAFG00000019030|UniProtKB=E2R776	Uncharacterized protein	ISS	10989446	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	DROME|FlyBase=FBgn0003301|UniProtKB=P32870	Ca(2+)/calmodulin-responsive adenylate cyclase	ISS			PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	BOVIN|Ensembl=ENSBTAG00000009269|UniProtKB=F1MCM2	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Ensembl=ENSBTAG00000005865|UniProtKB=G5E577	Uncharacterized protein	ISS	8444355	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00056	VEGF signaling pathway	P01417	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01227	20S proteasome	MOUSE|MGI=MGI=1920927|UniProtKB=Q9CWH6	Proteasome subunit alpha type-7-like	ISS	12859888	PubMed	PTHR11599:SF47	PROTEASOME SUBUNIT ALPHA TYPE-7-LIKE
P00005	Angiogenesis	P00182	p38MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00010	B cell activation	P00402	Jnk	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00049	Parkinson disease	P01223	UbcH8	HUMAN|HGNC=12490|UniProtKB=O14933	Ubiquitin/ISG15-conjugating enzyme E2 L6	IDA	11078524	PubMed	PTHR24068:SF43	UBIQUITIN/ISG15-CONJUGATING ENZYME E2 L6
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	RAT|RGD=620805|UniProtKB=G3V8K2	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00004	Alzheimer disease-presenilin pathway	P00129	Presenilin	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DANRE|ZFIN=ZDB-GENE-030131-6503|UniProtKB=Q7ZUC5	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF297	PROTEIN KINASE C DELTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	IC	14684598	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00047	PDGF signaling pathway	P01155	Jak	CANLF|Ensembl=ENSCAFG00000018615|UniProtKB=F1PIY7	Tyrosine-protein kinase	ISS	9637709	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	PANTR|Ensembl=ENSPTRG00000006216|UniProtKB=H2Q832	Adenylate cyclase 4	ISS	2491850	PubMed	PTHR11920:SF286	ADENYLATE CYCLASE TYPE 4
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DICDI|dictyBase=DDB_G0289487|UniProtKB=P07829	Actin-3	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00053	T cell activation	P01322	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00053	T cell activation	P01312	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	8394352	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01001	KA4	RAT|RGD=2734|UniProtKB=Q01812	Glutamate receptor ionotropic, kainate 4	IEA	12871085	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P02746	Heme biosynthesis	P02970	Coproporphyrinogen oxidase (oxygen independent)	MACMU|Ensembl=ENSMMUG00000017240|UniProtKB=F7HBT8	Uncharacterized protein	ISS			PTHR13932:SF14	RADICAL S-ADENOSYL METHIONINE DOMAIN-CONTAINING PROTEIN 1, MITOCHONDRIAL
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	SULSO|EnsemblGenome=SSO2440|UniProtKB=Q97W07	Glutamine synthetase (Glutamate ammonia ligase) (GS). (GlnA-2)	ISS			PTHR43785:SF1	TYPE-1 GLUTAMINE SYNTHETASE 2
P05731	GABA-B receptor II signaling	P05752	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P02779	Thiamin biosynthesis	P03170	Hydroxymethylpyrimidine phosphate kinase	YEAST|SGD=S000005416|UniProtKB=Q08224	Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20	ISS			PTHR20858:SF17	HYDROXYMETHYLPYRIMIDINE/PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	TAS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9062|UniProtKB=Q9BRC7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	ISS	12860966	PubMed	PTHR10336:SF31	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=1951|UniProtKB=P08172	Muscarinic acetylcholine receptor M2	IDA	8100450	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04585	TRH	BOVIN|Ensembl=ENSBTAG00000016138|UniProtKB=P01217	Glycoprotein hormones alpha chain	ISS			PTHR11509:SF0	GLYCOPROTEIN HORMONES ALPHA CHAIN
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00047	PDGF signaling pathway	P01143	ERK	ORYSJ|Gene=Os01g0665200|UniProtKB=Q5SN53	Mitogen-activated protein kinase 8	ISS	176948	OMIM	PTHR24055:SF219	SUBFAMILY NOT NAMED
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02920	dCTP deaminase	BACSU|EnsemblGenome=BSU00180|UniProtKB=P21335	tRNA-specific adenosine deaminase	ISS			PTHR11079:SF149	TRNA-SPECIFIC ADENOSINE DEAMINASE
P00053	T cell activation	P01298	NFkappaB	RAT|RGD=70498|UniProtKB=Q63369	Nuclear factor NF-kappa-B p105 subunit (Fragment)	ISS	12574369	PubMed	PTHR24169:SF9	NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT
P00053	T cell activation	P01306	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00370	NFkappaB	PANTR|Ensembl=ENSPTRG00000002888|UniProtKB=H2Q2H2	Uncharacterized protein	ISS	9133421	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00053	T cell activation	P01312	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8393135	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P06211	BMP/activin signaling pathway-drosophila	P06251	BMP/activin orthologous ligand	DROME|FlyBase=FBgn0026199|UniProtKB=Q9V4F4	LD29161p	RCA	16098524	PubMed	PTHR11848:SF176	LD29161P
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00001	Adrenaline and noradrenaline biosynthesis	P00061	PNMT	HUMAN|HGNC=6069|UniProtKB=O95050	Indolethylamine N-methyltransferase	ISS			PTHR10867:SF6	INDOLETHYLAMINE N-METHYLTRANSFERASE-RELATED
P00018	EGF receptor signaling pathway	P00561	STAT	CANLF|Ensembl=ENSCAFG00000015509|UniProtKB=F1PNW8	Signal transducer and activator of transcription	ISS	10835485	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P04398	p53 pathway feedback loops 2	P04665	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00037	Ionotropic glutamate receptor pathway	P01026	KA	CHICK|Ensembl=ENSGALG00000006638|UniProtKB=R4GGL9	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00030	Hypoxia response via HIF activation	P00819	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00931	Integrin beta	ANOGA|EnsemblGenome=AGAP000815|UniProtKB=Q7QE55	Integrin beta	IDA	3487386	PubMed	PTHR10082:SF41	INTEGRIN BETA-PS
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DANRE|ZFIN=ZDB-GENE-030131-6503|UniProtKB=Q7ZUC5	Protein kinase C delta type	ISS	11880265	PubMed	PTHR24356:SF297	PROTEIN KINASE C DELTA TYPE
P00011	Blood coagulation	P00450	Tissue Factor	HUMAN|HGNC=3541|UniProtKB=P13726	Tissue factor	ISS	4503641	gi	PTHR20859:SF22	TISSUE FACTOR
P05913	Enkephalin release	P05974	G-Protein (i)	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00911	B-Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	12639709	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	ANOGA|EnsemblGenome=AGAP007120|UniProtKB=Q7QIX6	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00046	Oxidative stress response	P01125	Stat1	HUMAN|HGNC=11362|UniProtKB=P42224	Signal transducer and activator of transcription 1-alpha/beta	TAS	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	MACMU|Ensembl=ENSMMUG00000014807|UniProtKB=F6W548	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	MONDO|Ensembl=ENSMODG00000004610|UniProtKB=F6Y3N2	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P02738	De novo purine biosynthesis	P02892	5-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase	METJA|EnsemblGenome=MJ_0929|UniProtKB=Q58339	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	ORYSJ|EnsemblGenome=OS02G0834000|UniProtKB=Q6EP31	Rac-like GTP-binding protein 5	ISS	12932731	PubMed	PTHR24072:SF194	RAC-LIKE GTP-BINDING PROTEIN ARAC4-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	ASHGO|EnsemblGenome=AGOS_ABR222W|UniProtKB=Q75D00	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	P01465	Ggamma	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00018	EGF receptor signaling pathway	P00564	Rac	MOUSE|MGI=MGI=97845|UniProtKB=P63001	Ras-related C3 botulinum toxin substrate 1	ISS	10891487	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000002194|UniProtKB=F6WM87	Uncharacterized protein	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01188	Gbetagamma	NEUCR|EnsemblGenome=EFNCRG00000000159|UniProtKB=F5HH30	Guanine nucleotide-binding protein beta subunit	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	CANLF|Ensembl=ENSCAFG00000002046|UniProtKB=E2RBE7	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00029	Huntington disease	P00780	Microtubule	PLAF7|EnsemblGenome=PF10_0084|UniProtKB=Q7KQL5	Tubulin beta chain	IDA	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00010	B cell activation	P00388	PLC gamma2	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P02721	ATP synthesis	P02791	F1 alpha	HUMAN|HGNC=823|UniProtKB=P25705	ATP synthase subunit alpha, mitochondrial	ISS	2527557	PubMed	PTHR43089:SF4	ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL
P00018	EGF receptor signaling pathway	P00562	p38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00021	FGF signaling pathway	P00644	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IGI	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	10395542	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00021	FGF signaling pathway	P00627	ERK1-2	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00965	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00012	Cadherin signaling pathway	P00470	F-actin	XENTR|Xenbase=XB-GENE-491618|UniProtKB=Q6P378	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00052	TGF-beta signaling pathway	P01275	P38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	TAS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	HUMAN|HGNC=705|UniProtKB=O15144	Actin-related protein 2/3 complex subunit 2	ISS	12473693	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	MOUSE|MGI=MGI=109123|UniProtKB=P70225	Interleukin-11 receptor subunit alpha-2	IEP	8973540	PubMed	PTHR23036:SF29	INTERLEUKIN-11 RECEPTOR SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00543	ERK1-2	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	9603989	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00004	Alzheimer disease-presenilin pathway	P00141	Membrane metalloprotease	CANLF|Ensembl=ENSCAFG00000008544|UniProtKB=F1P625	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF25	MATRIX METALLOPROTEINASE-15
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004886|UniProtKB=H2Q5T7	Calcium channel, voltage-dependent, beta 3 subunit	ISS			PTHR11824:SF8	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-3
P04393	Ras Pathway	P04578	Rho	RAT|RGD=1304965|UniProtKB=A0A0G2K6E0	Protein Rhoc	ISS	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00019	Endothelin signaling pathway	P00589	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	RCA	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00029	Huntington disease	P00788	Calpain	PANTR|Ensembl=ENSPTRG00000002097|UniProtKB=H2Q1B8	Uncharacterized protein	ISS	11675509	PubMed	PTHR10183:SF385	CALPAIN-9
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00034	Integrin signalling pathway	P00912	Arp2/3	HUMAN|HGNC=704|UniProtKB=O15143	Actin-related protein 2/3 complex subunit 1B	IPI	12963527	gi	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	BOVIN|Ensembl=ENSBTAG00000008719|UniProtKB=F1MZX0	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00041	Metabotropic glutamate receptor group I pathway	P01061	mGluR5	RAT|RGD=2746|UniProtKB=P31424	Metabotropic glutamate receptor 5	ISS	92317054	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P02771	Pyrimidine Metabolism	P03124	Methylmalonate Semialdehyde Dehydrogenase	ORYSJ|EnsemblGenome=OS07G0188800|UniProtKB=Q6Z4E4	Methylmalonate semi-aldehyde dehydrogenase	TAS	7431455	gi	PTHR43866:SF3	METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE  ACYLATING , MITOCHONDRIAL
P00010	B cell activation	P00402	Jnk	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00045	Notch signaling pathway	P01113	Pen-2	CHICK|Gene=PSEN2|UniProtKB=Q90X07	Presenilin-2	ISS	14598311	PubMed	PTHR10202:SF13	PRESENILIN-2
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	SCHPO|PomBase=SPAC8C9.03|UniProtKB=P36600	cAMP-dependent protein kinase regulatory subunit	IC	2372396	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P02728	Arginine biosynthesis	P02845	Carbamoyl phosphate synthase	BACSU|EnsemblGenome=BSU11240|UniProtKB=P18185	Carbamoyl-phosphate synthase arginine-specific large chain	ISS			PTHR11405:SF5	CAD PROTEIN
P04398	p53 pathway feedback loops 2	P04665	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000008503|UniProtKB=F6TGJ6	Uncharacterized protein	ISS	8444355	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00048	PI3 kinase pathway	P01177	P110ACT	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	BOVIN|Ensembl=ENSBTAG00000019090|UniProtKB=E1B7G7	Uncharacterized protein	ISS			PTHR22903:SF17	PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY H MEMBER 3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	TAS	11554554	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	HUMAN|HGNC=4580|UniProtKB=Q13002	Glutamate receptor ionotropic, kainate 2	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	CAEEL|WormBase=WBGene00002191|UniProtKB=P18334	Casein kinase II subunit alpha	IDA	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P05913	Enkephalin release	P05978	AC	BOVIN|Ensembl=ENSBTAG00000019210|UniProtKB=F1MJV4	Uncharacterized protein	ISS	12472880	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IDA	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04393	Ras Pathway	P04579	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	7680960	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	HUMAN|HGNC=232|UniProtKB=Q08828	Adenylate cyclase type 1	ISS	2491850	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	DROME|FlyBase=FBgn0011300|UniProtKB=A1Z7L8	Receptor protein serine/threonine kinase	TAS	http://flybase.org/reports/FBgn0011300.html	Website	PTHR23255:SF71	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BOVIN|Ensembl=ENSBTAG00000020645|UniProtKB=A7MBH9	GNAI2 protein	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	HUMAN|HGNC=8528|UniProtKB=P01178	Oxytocin-neurophysin 1	ISS			PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00048	PI3 kinase pathway	P01192	p110	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=620027|UniProtKB=P08911	Muscarinic acetylcholine receptor M5	IDA			PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	CAEEL|WormBase=WBGene00001985|UniProtKB=O02100	Presenilin hop-1	TAS	8755489	PubMed	PTHR10202:SF14	PRESENILIN HOP-1
P00006	Apoptosis signaling pathway	P00297	NFkappaB	PANTR|Ensembl=ENSPTRG00000016320|UniProtKB=H2QPY8	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	ISS	12574369	PubMed	PTHR24169:SF9	NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04398	p53 pathway feedback loops 2	P04665	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	CAEEL|WormBase=WBGene00000066|UniProtKB=P10986	Actin-4	IC	11889126	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	DANRE|Ensembl=ENSDARG00000059090|UniProtKB=E7FDL0	Uncharacterized protein	ISS	12562507	PubMed	PTHR24229:SF75	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01199	Galpha	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	ARATH|TAIR=AT5G58670|UniProtKB=Q39032	Phosphoinositide phospholipase C 1	TAS			PTHR10336:SF105	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IDA	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00010	B cell activation	P00402	Jnk	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	11007936	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00059	p53 pathway	P04633	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00572	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	93203266	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	DANRE|ZFIN=ZDB-GENE-990415-25|UniProtKB=P79733	Ribonucleoside-diphosphate reductase subunit M2	ISS			PTHR23409:SF20	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00056	VEGF signaling pathway	P01422	eNOS	MACMU|Ensembl=ENSMMUG00000020437|UniProtKB=F6WEB2	Nitric oxide synthase	ISS	93055452	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P04395	Vasopressin synthesis	P04593	Glycopeptide	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	IC	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00021	FGF signaling pathway	P00633	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	XENTR|Xenbase=XB-GENE-957124|UniProtKB=F7BDN8	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00096	Abeta	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00019	Endothelin signaling pathway	P00589	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00003	Alzheimer disease-amyloid secretase pathway	P00093	Tip60	HUMAN|HGNC=580|UniProtKB=O96018	Amyloid beta A4 precursor protein-binding family A member 3	IC			PTHR12345:SF9	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 3
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00046	Oxidative stress response	P01134	cPLA2	MACMU|Ensembl=ENSMMUG00000021423|UniProtKB=F7EEZ1	Phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Gene=DRD2|UniProtKB=P20288	D(2) dopamine receptor	IDA	2137198	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P02752	Mannose metabolism	P03018	Mannose 1-P guanylyl transferase	ASHGO|EnsemblGenome=AGOS_AFR599W|UniProtKB=Q752H4	Mannose-1-phosphate guanyltransferase	ISS	4760690	gi	PTHR22572:SF15	MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE BETA
P06587	Nicotine pharmacodynamics pathway	P06595	CHRNA3	BOVIN|Gene=CHRNA3|UniProtKB=Q07263	Neuronal acetylcholine receptor subunit alpha-3	ISS	12098588	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P00056	VEGF signaling pathway	P01419	Ets	XENTR|Xenbase=XB-GENE-6465484|UniProtKB=B3DM35	LOC100170599 protein	ISS	15298723	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	IC	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00004	Alzheimer disease-presenilin pathway	P00128	Erb-B4	MONDO|Ensembl=ENSMODG00000015755|UniProtKB=F6ZSZ9	Uncharacterized protein (Fragment)	ISS	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00750	Rhodopsin kinase	HUMAN|HGNC=10013|UniProtKB=Q15835	Rhodopsin kinase	IDA	8288567	PubMed	PTHR24355:SF11	RHODOPSIN KINASE
P04393	Ras Pathway	P04558	p38	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	IDA	4506785	gi	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=11438|UniProtKB=Q13277	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	MONDO|Ensembl=ENSMODG00000015246|UniProtKB=F6UJF5	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00046	Oxidative stress response	P01125	Stat1	MOUSE|MGI=MGI=103063|UniProtKB=P42225	Signal transducer and activator of transcription 1	TAS	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00005	Angiogenesis	P00217	STAT3	MACMU|Ensembl=ENSMMUG00000010707|UniProtKB=F7G8G5	Signal transducer and activator of transcription	ISS	12595539	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00021	FGF signaling pathway	P00633	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P06587	Nicotine pharmacodynamics pathway	P06599	EPB41L1	MOUSE|MGI=MGI=103010|UniProtKB=Q9Z2H5	Band 4.1-like protein 1	RCA	12181426	PubMed	PTHR23280:SF24	BAND 4.1-LIKE PROTEIN 1
P00034	Integrin signalling pathway	P00925	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00006	Apoptosis signaling pathway	P00321	HSP70	CAEBR|Gene=CBG22024|UniProtKB=A8Y1C9	Protein CBR-HSP-70	ISS	12150907	PubMed	PTHR19375:SF207	HEAT SHOCK PROTEIN
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MONDO|Ensembl=ENSMODG00000020977|UniProtKB=F6S5B1	Uncharacterized protein (Fragment)	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01236	Casein kinase II	MOUSE|MGI=MGI=88547|UniProtKB=O54833	Casein kinase II subunit alpha'	IDA	10617630	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	MOUSE|MGI=MGI=1347050|UniProtKB=O35945	Aldehyde dehydrogenase, cytosolic 1	IC			PTHR11699:SF221	ALDEHYDE DEHYDROGENASE, CYTOSOLIC 1
P00050	Plasminogen activating cascade	P01257	tPA	HUMAN|HGNC=9051|UniProtKB=P00750	Tissue-type plasminogen activator	IDA	4505861	gi	PTHR44617:SF1	TISSUE-TYPE PLASMINOGEN ACTIVATOR
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00025	Hedgehog signaling pathway	P00692	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00053	T cell activation	P01331	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P02778	Sulfate assimilation	P03167	Sulfate adenylyltransferase	CAEBR|Gene=CBG03405|UniProtKB=A8WUZ3	Protein CBR-PPS-1	ISS			PTHR11055:SF1	PAPS SYNTHETASE, ISOFORM D
P04376	5HT4 type receptor mediated signaling pathway	P04432	5HT vesicular transporter	HUMAN|HGNC=10935|UniProtKB=Q05940	Synaptic vesicular amine transporter	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00558	SOS	DICDI|dictyBase=DDB_G0281573|UniProtKB=Q54TK8	Ras guanine nucleotide exchange factor P	ISS			PTHR23113:SF309	RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR P
P00020	FAS signaling pathway	P00615	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00054	Toll receptor signaling pathway	P01352	p38	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MACMU|Ensembl=ENSMMUG00000005483|UniProtKB=F7G271	Uncharacterized protein	ISS	15116068	PubMed	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00006	Apoptosis signaling pathway	P00301	Apaf-1	HUMAN|HGNC=576|UniProtKB=O14727	Apoptotic protease-activating factor 1	IDA	10364241	PubMed	PTHR22845:SF5	APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
P00053	T cell activation	P01333	cdc42	HUMAN|HGNC=1736|UniProtKB=P60953	Cell division control protein 42 homolog	IDA	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00021	FGF signaling pathway	P00645	Rac	MACMU|Ensembl=ENSMMUG00000021075|UniProtKB=F7GY91	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00057	Wnt signaling pathway	P01465	Ggamma	RAT|RGD=621516|UniProtKB=G3V6P8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P05915	Opioid proenkephalin pathway	P05994	G-protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	8327893	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00029	Huntington disease	P00775	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	TAS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P05730	Endogenous cannabinoid signaling	P05751	Galpha	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00560	Raf-1	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01167	Ets	RAT|RGD=2583|UniProtKB=P41156	Protein C-ets-1	ISS	9157999	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00005	Angiogenesis	P00198	Survivin	CHICK|Ensembl=ENSGALG00000008713|UniProtKB=F1NN48	Uncharacterized protein	ISS	9256286	PubMed	PTHR10044:SF163	BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 7
P00053	T cell activation	P01322	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00892	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	4504111	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P02723	Adenine and hypoxanthine salvage pathway	P02805	Adenine phosphorylase	DROME|FlyBase=FBgn0035348|UniProtKB=M9PE19	Uncharacterized protein, isoform H	ISS			PTHR11904:SF9	PURINE NUCLEOSIDE PHOSPHORYLASE
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00093	Tip60	MOUSE|MGI=MGI=1932051|UniProtKB=Q8CHK4	Histone acetyltransferase KAT5	IDA	11441186	PubMed	PTHR10615:SF124	HISTONE ACETYLTRANSFERASE KAT5
P00012	Cadherin signaling pathway	P00474	Wnt	HUMAN|HGNC=12783|UniProtKB=P56705	Protein Wnt-4	IDA	8717036	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DICPU|Gene=DICPUDRAFT_93216|UniProtKB=F1A421	Guanine nucleotide-binding protein subunit beta	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00021	FGF signaling pathway	P00640	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00626	Spry	HUMAN|HGNC=15533|UniProtKB=Q9C004	Protein sprouty homolog 4	ISS	99264295	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P00049	Parkinson disease	P01235	Fyn kinase	CANLF|Ensembl=ENSCAFG00000003995|UniProtKB=E2RC09	Tyrosine-protein kinase	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000001789|UniProtKB=F7GIU0	5-hydroxytryptamine receptor 1A	ISS	12181435	PubMed	PTHR24247:SF20	5-HYDROXYTRYPTAMINE RECEPTOR 1A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CANLF|Ensembl=ENSCAFG00000015708|UniProtKB=F2Z4N0	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00029	Huntington disease	P00799	JNK-2	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01446	Calcineurin	PANTR|Ensembl=ENSPTRG00000020059|UniProtKB=H2QVV0	Serine/threonine-protein phosphatase	ISS	12091710	PubMed	PTHR11668:SF186	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT GAMMA ISOFORM
P05918	p38 MAPK pathway	P06013	ELK	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	RCA	11279280	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00034	Integrin signalling pathway	P00912	Arp2/3	DICDI|dictyBase=DDB_G0288319|UniProtKB=O96626	Actin-related protein 2/3 complex subunit 5	IPI	12473693	PubMed	PTHR12644:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00036	Interleukin signaling pathway	P00965	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	MACMU|Ensembl=ENSMMUG00000017022|UniProtKB=F7HQZ9	Uncharacterized protein	ISS	15123653	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P06959	CCKR signaling map	P07212	p85	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	RCA	10094466	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00060	Ubiquitin proteasome pathway	P01491	E2	MONDO|Ensembl=ENSMODG00000024398|UniProtKB=F6Z480	Uncharacterized protein	ISS			PTHR43915:SF3	UBIQUITIN-CONJUGATING ENZYME E2 VARIANT 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IDA	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00006	Apoptosis signaling pathway	P00310	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00638	PLCgamma	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P02738	De novo purine biosynthesis	P02903	Phosphoribosylglycinamide  formyltransferase	BACSU|EnsemblGenome=BSU06510|UniProtKB=P12040	Phosphoribosylglycinamide formyltransferase	ISS			PTHR43369:SF2	PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00005	Angiogenesis	P00244	MAPKAPK2/3	ORNAN|Ensembl=ENSOANG00000007737|UniProtKB=F6PX17	Uncharacterized protein	ISS			PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IDA	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	91056091	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=11439|UniProtKB=Q12846	Syntaxin-4	ISS			PTHR19957:SF97	SYNTAXIN-4
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Ensembl=ENSPTRG00000011042|UniProtKB=H2QGF5	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00029	Huntington disease	P00778	NMDA receptor	RAT|RGD=2738|UniProtKB=Q00960	Glutamate receptor ionotropic, NMDA 2B	IDA	11319238	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IDA	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	CANLF|Ensembl=ENSCAFG00000010034|UniProtKB=F1PEE8	Uncharacterized protein	ISS	8930069	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P00018	EGF receptor signaling pathway	P00557	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00965	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00046	Oxidative stress response	P01127	eEF2K	RAT|RGD=2538|UniProtKB=P70531	Eukaryotic elongation factor 2 kinase	TAS	11500363	PubMed	PTHR14187:SF56	EUKARYOTIC ELONGATION FACTOR 2 KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	IDA	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	RAT|RGD=70497|UniProtKB=Q05982	Nucleoside diphosphate kinase A	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P00049	Parkinson disease	P01219	SAPK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00005	Angiogenesis	P00227	PLA2	CANLF|Ensembl=ENSCAFG00000013778|UniProtKB=F6UQ33	Phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00047	PDGF signaling pathway	P01169	Vav	BOVIN|Ensembl=ENSBTAG00000031575|UniProtKB=E1BBD2	Uncharacterized protein	ISS	14623913	PubMed	PTHR22826:SF97	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00828	Galphai	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	RCA			PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00543	ERK1-2	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00010	B cell activation	P00401	jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	MACMU|Ensembl=ENSMMUG00000007593|UniProtKB=F6SK82	Uncharacterized protein	ISS	10487978	PubMed	PTHR10749:SF4	PHOSPHORYLASE B KINASE REGULATORY SUBUNIT ALPHA, SKELETAL MUSCLE ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00869	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P04393	Ras Pathway	P04546	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	TAS	97320448	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MACMU|Ensembl=ENSMMUG00000022347|UniProtKB=F6ZCH5	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	7925653	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00475	Frizzled	ORNAN|Ensembl=ENSOANG00000008874|UniProtKB=F7F2K2	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF23	FRIZZLED-4
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04393	Ras Pathway	P04541	p90RSK	MOUSE|MGI=MGI=104558|UniProtKB=P18653	Ribosomal protein S6 kinase alpha-1	IDA	12769834	PubMed	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00005	Angiogenesis	P00223	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06856	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	RCA	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00053	T cell activation	P01332	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=88399|UniProtKB=P32211	Muscarinic acetylcholine receptor M4	IDA	11166329	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	DICPU|Gene=DICPUDRAFT_93216|UniProtKB=F1A421	Guanine nucleotide-binding protein subunit beta	ISS	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00019	Endothelin signaling pathway	P00566	ERK	EMENI|EnsemblGenome=CADANIAG00005005|UniProtKB=C8V7D1	Mitogen-activated protein kinase	NAS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	BOVIN|Ensembl=ENSBTAG00000012687|UniProtKB=F1MV64	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00018	EGF receptor signaling pathway	P00547	PP2A	MOUSE|MGI=MGI=2388481|UniProtKB=Q91V89	Protein Ppp2r5d	ISS	12110603	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00965	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00012	Cadherin signaling pathway	P00466	EGFR	MACMU|Gene=EGFR|UniProtKB=P55245	Epidermal growth factor receptor	ISS	21100872	PubMed	PTHR24416:SF91	EPIDERMAL GROWTH FACTOR RECEPTOR
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	ORNAN|Ensembl=ENSOANG00000006415|UniProtKB=F6WIC7	Uncharacterized protein	ISS	12374786	PubMed	PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01063	CAT	ANOGA|EnsemblGenome=AGAP002370|UniProtKB=Q7QBZ0	AGAP002370-PA (Fragment)	IC	97225904	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P04393	Ras Pathway	P04545	Sec5	CAEEL|WormBase=WBGene00004752|UniProtKB=Q22706	Exocyst complex component 2	ISS			PTHR13043:SF1	EXOCYST COMPLEX COMPONENT 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	PANTR|Ensembl=ENSPTRG00000014058|UniProtKB=H2QL83	Clathrin heavy chain	ISS	9388255	PubMed	PTHR10292:SF6	CLATHRIN HEAVY CHAIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	MOUSE|MGI=MGI=109284|UniProtKB=Q61144	Presenilin-2	TAS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	RAT|RGD=620838|UniProtKB=Q8VHK6	Interleukin-13 receptor subunit alpha-2	ISS	9725226	PubMed	PTHR23036:SF101	INTERLEUKIN-13 RECEPTOR SUBUNIT ALPHA-2
P00018	EGF receptor signaling pathway	P00551	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04546	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00021	FGF signaling pathway	P00631	Grb2	CAEEL|WormBase=WBGene00004774|UniProtKB=P29355	Sex muscle abnormal protein 5	IPI	4504111	gi	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00037	Ionotropic glutamate receptor pathway	P01009	NR3	CANLF|Ensembl=ENSCAFG00000002617|UniProtKB=E2QUL1	Uncharacterized protein	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000037429|UniProtKB=F1MGM3	Uncharacterized protein	ISS	11701344	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01428	Frizzled	RAT|RGD=71012|UniProtKB=Q08464	Frizzled-2	IDA	8717036	PubMed	PTHR11309:SF34	FRIZZLED-2
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	DICPU|Gene=DICPUDRAFT_47166|UniProtKB=F0ZI20	Beta tubulin	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	MACMU|Ensembl=ENSMMUG00000004229|UniProtKB=F6SNN4	Uncharacterized protein	ISS			PTHR22778:SF16	DIHYDROFOLATE REDUCTASE
P00053	T cell activation	P01318	PKC-theta	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00018	EGF receptor signaling pathway	P00561	STAT	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	12191995	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00629	PP2A	PANTR|Ensembl=ENSPTRG00000042450|UniProtKB=H2R9V8	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B	ISS	137056	PubMed	PTHR11871:SF2	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DICDI|dictyBase=DDB_G0268744|UniProtKB=Q55EU6	Putative actin-23	IC	10974003	PubMed	PTHR11937:SF154	ACTIN-17-RELATED
P00021	FGF signaling pathway	P00638	PLCgamma	MACMU|Ensembl=ENSMMUG00000005334|UniProtKB=F7GH26	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	10644715	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00056	VEGF signaling pathway	P01407	Erk	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01207	PLD2	MOUSE|MGI=MGI=892877|UniProtKB=P97813	Phospholipase D2	IDA	9538008	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00053	T cell activation	P01324	rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00010	B cell activation	P00381	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	BOVIN|Gene=MMP1|UniProtKB=P28053	Interstitial collagenase	TAS	12834808	PubMed	PTHR10201:SF151	INTERSTITIAL COLLAGENASE
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	METAC|EnsemblGenome=MA_2144|UniProtKB=Q8TNY3	Carbamoyl-phosphate synthase small chain	ISS			PTHR11405:SF4	CARBAMOYL-PHOSPHATE SYNTHASE ARGININE-SPECIFIC SMALL CHAIN
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00029	Huntington disease	P00780	Microtubule	PANTR|Ensembl=ENSPTRG00000017675|UniProtKB=H2QS81	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	IC	10553940	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00018	EGF receptor signaling pathway	P00551	Akt	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	IGI	22081553	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00005	Angiogenesis	P00218	STAT1	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	10851045	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	IDA	9065779	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04384	Gamma-aminobutyric acid synthesis	P04482	Glutamate decarboxylase	RAT|RGD=621030|UniProtKB=Q64611	Cysteine sulfinic acid decarboxylase	ISS			PTHR11999:SF114	CYSTEINE SULFINIC ACID DECARBOXYLASE
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	CAEEL|WormBase=WBGene00000900|UniProtKB=P50488	Cell surface receptor daf-4	IDA	9395284	PubMed	PTHR23255:SF70	SERINE/THREONINE-PROTEIN KINASE RECEPTOR
P04393	Ras Pathway	P04568	MKK3/6	RAT|RGD=620666|UniProtKB=Q925D6	Mitogen-activated protein kinase kinase 6	RCA			PTHR24361:SF40	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P00029	Huntington disease	P00779	TBP	DROME|FlyBase=FBgn0003687|UniProtKB=P20227	TATA-box-binding protein	IPI	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	PANTR|Gene=CXCR1|UniProtKB=P55920	C-X-C chemokine receptor type 1	ISS	4504683	gi	PTHR10489:SF916	C-X-C CHEMOKINE RECEPTOR TYPE 1
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	HUMAN|HGNC=4579|UniProtKB=P39086	Glutamate receptor ionotropic, kainate 1	ISS	12778120	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	11722588	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P02736	Coenzyme A biosynthesis	P02885	Pantothenate kinase	RAT|RGD=1304677|UniProtKB=D3ZWD3	Pantothenate kinase 1 (Predicted), isoform CRA_a	ISS			PTHR12280:SF23	PANTOTHENATE KINASE 1
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	BACTN|EnsemblGenome=BT_1970|UniProtKB=P94598	Glutamate dehydrogenase	ISS			PTHR43571:SF1	NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED
P00029	Huntington disease	P00807	Actin	CANLF|Ensembl=ENSCAFG00000016020|UniProtKB=O18840	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02925	Carbamoyl phosphate synthetase	ECOLI|EcoGene=EG10135|UniProtKB=P00968	Carbamoyl-phosphate synthase large chain	ISS			PTHR11405:SF5	CAD PROTEIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	MOUSE|MGI=MGI=1927091|UniProtKB=Q5SUA5	Unconventional myosin-Ig	ISS			PTHR13140:SF381	UNCONVENTIONAL MYOSIN-IG
P00046	Oxidative stress response	P01135	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	SCHPO|PomBase=SPBC32H8.12c|UniProtKB=P10989	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00046	Oxidative stress response	P01135	p38	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	TAS	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00048	PI3 kinase pathway	G01544	GADD45	BOVIN|Ensembl=ENSBTAG00000013860|UniProtKB=Q3ZBN6	Growth arrest and DNA damage-inducible protein GADD45 alpha	ISS	10097101	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P02746	Heme biosynthesis	P02981	Glutamate-1-semialdehyde aminotransferase	FUSNN|EnsemblGenome=FN0540|UniProtKB=Q8RFY7	Glutamate-1-semialdehyde 2,1-aminomutase	ISS			PTHR43713:SF3	GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE
P00056	VEGF signaling pathway	P01425	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06752	BMP6/7	MOUSE|MGI=MGI=88182|UniProtKB=P20722	Bone morphogenetic protein 6	RCA	9759503	PubMed	PTHR11848:SF137	BONE MORPHOGENETIC PROTEIN 6
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	PANTR|Gene=CHRM3|UniProtKB=Q9N2A4	Muscarinic acetylcholine receptor M3	ISS	12181435	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00052	TGF-beta signaling pathway	P01286	TGFbeta	PANTR|Ensembl=ENSPTRG00000002475|UniProtKB=H2R170	Bone morphogenetic protein 3	ISS	9759503	PubMed	PTHR11848:SF145	GROWTH/DIFFERENTIATION FACTOR 10
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01178	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8479536	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	ISS	91072385	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00173	LRP intracellular fragment	PANTR|Ensembl=ENSPTRG00000003983|UniProtKB=H2Q4A0	Uncharacterized protein	ISS	11907044	PubMed	PTHR44017:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5
P00010	B cell activation	P00391	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00052	TGF-beta signaling pathway	P01276	Co-Smads	ORNAN|Ensembl=ENSOANG00000008117|UniProtKB=F7F4A2	Mothers against decapentaplegic homolog	ISS	10693808	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P02723	Adenine and hypoxanthine salvage pathway	P02810	Adenine phosphoribosyl transferase	YEAST|SGD=S000002849|UniProtKB=P36973	Adenine phosphoribosyltransferase 2	ISS			PTHR32315:SF3	ADENINE PHOSPHORIBOSYLTRANSFERASE
P00048	PI3 kinase pathway	P01202	p85	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	15313841	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00005	Angiogenesis	P00204	PLD	PANTR|Ensembl=ENSPTRG00000008610|UniProtKB=H2QBY9	Uncharacterized protein	ISS	9538008	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P00037	Ionotropic glutamate receptor pathway	P01006	NR2C	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	ISS			PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00036	Interleukin signaling pathway	P00981	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00048	PI3 kinase pathway	P01185	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00021	FGF signaling pathway	P00640	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00019	Endothelin signaling pathway	P00566	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00017	DNA replication	P00528	Primase	MOUSE|MGI=MGI=97757|UniProtKB=P20664	DNA primase small subunit	ISS	10441007	PubMed	PTHR10536:SF0	DNA PRIMASE SMALL SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	MACMU|Ensembl=ENSMMUG00000002061|UniProtKB=F6WWR1	Uncharacterized protein	ISS			PTHR42884:SF12	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 7
P00021	FGF signaling pathway	P00624	14-3-3	DICDI|dictyBase=DDB_G0269138|UniProtKB=P54632	14-3-3-like protein	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00057	Wnt signaling pathway	P01444	Wnt	RAT|RGD=1562253|UniProtKB=D4A3K6	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF70	PROTEIN WNT-16
P00018	EGF receptor signaling pathway	P00551	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IGI	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00238	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02757	O-antigen biosynthesis	P03045	dTDP-glucose 4,6-dehydratase	SCHPO|PomBase=SPBPB2B2.11|UniProtKB=Q9HDU4	Uncharacterized protein PB2B2.11	ISS			PTHR43000:SF7	DTDP-D-GLUCOSE 4,6-DEHYDRATASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	HUMAN|HGNC=4412|UniProtKB=O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	RCA	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00021	FGF signaling pathway	P00629	PP2A	PANTR|Ensembl=ENSPTRG00000017377|UniProtKB=H2RCR7	Uncharacterized protein	ISS	12110603	PubMed	PTHR11871:SF1	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B BETA ISOFORM
P00029	Huntington disease	P00807	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g169611|UniProtKB=A7SEB1	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00060	Ubiquitin proteasome pathway	P01490	E3	SCHPO|PomBase=SPBP8B7.27|UniProtKB=O94275	Probable E3 ubiquitin-protein ligase mug30	ISS			PTHR11254:SF354	HECT AND RCC DOMAIN E3 UBIQUITIN LIGASE
P00052	TGF-beta signaling pathway	P01286	TGFbeta	CAEEL|WormBase=WBGene00000936|UniProtKB=G5EEL5	DPP/BMP-Like	TAS	9759503	PubMed	PTHR11848:SF168	DPP/BMP-LIKE
P00057	Wnt signaling pathway	P01427	Naked	MOUSE|MGI=MGI=1919543|UniProtKB=Q8VE28	Protein naked cuticle homolog 2	ISS	11356022	PubMed	PTHR22611:SF1	PROTEIN NAKED CUTICLE HOMOLOG 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00846	JAK	BOVIN|Ensembl=ENSBTAG00000012047|UniProtKB=E1BCP6	Tyrosine-protein kinase	ISS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00021	FGF signaling pathway	P00633	Ras	DICDI|dictyBase=DDB_G0293434|UniProtKB=P15064	Ras-like protein rasG	ISS	7997267	PubMed	PTHR24070:SF282	RAS GTPASE-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00053	T cell activation	P01298	NFkappaB	MACMU|Ensembl=ENSMMUG00000003736|UniProtKB=F7HKH9	Nuclear factor NF-kappa-B p105 subunit isoform 1	ISS	12574369	PubMed	PTHR24169:SF9	NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00021	FGF signaling pathway	P00638	PLCgamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00644	p38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IGI	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=1930705|UniProtKB=P61264	Syntaxin-1B	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	DROME|FlyBase=FBgn0004611|UniProtKB=P25455	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II	TAS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P04397	p53 pathway by glucose deprivation	P04641	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01174	Rho	BOVIN|Ensembl=ENSBTAG00000004685|UniProtKB=F1MJI3	Uncharacterized protein	ISS			PTHR14166:SF8	SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 3
P00005	Angiogenesis	P00190	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	14707121	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00021	FGF signaling pathway	P00632	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01428	Frizzled	MOUSE|MGI=MGI=1888513|UniProtKB=Q9JIP6	Frizzled-2	IDA	11212302	PubMed	PTHR11309:SF34	FRIZZLED-2
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	CANLF|Ensembl=ENSCAFG00000014987|UniProtKB=E2RH98	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF89	PROTEIN WNT-10A
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004886|UniProtKB=H2Q5T7	Calcium channel, voltage-dependent, beta 3 subunit	ISS			PTHR11824:SF8	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-3
P00057	Wnt signaling pathway	P01446	Calcineurin	MOUSE|MGI=MGI=107172|UniProtKB=Q63810	Calcineurin subunit B type 1	ISS	12015605	PubMed	PTHR23056:SF43	CALCINEURIN SUBUNIT B TYPE 1
P00021	FGF signaling pathway	P00627	ERK1-2	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00048	PI3 kinase pathway	P01179	PKB	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01188	Gbetagamma	PANTR|Ensembl=ENSPTRG00000007084|UniProtKB=H2Q9G5	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	TAS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000007754|UniProtKB=F7BXD9	Uncharacterized protein	ISS	8120095	PubMed	PTHR43956:SF6	PROTOCADHERIN-16
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	MACMU|Ensembl=ENSMMUG00000019761|UniProtKB=F7AQR3	Guanine nucleotide-binding protein subunit alpha-14	RCA			PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	PHYIT|EnsemblGenome=PITG_06376|UniProtKB=D0N4Q3	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta, putative	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	DROME|FlyBase=FBgn0003416|UniProtKB=Q9VXH3	Phosphoinositide phospholipase C	ISS			PTHR10336:SF91	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00005	Angiogenesis	P00256	PLC-gamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00018	EGF receptor signaling pathway	P00559	MEK1-2	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IGI	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	8170357	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00012	Cadherin signaling pathway	P00475	Frizzled	DANRE|ZFIN=ZDB-GENE-000328-4|UniProtKB=B0S6S2	Uncharacterized protein	IDA	11212302	PubMed	PTHR11309:SF90	FRIZZLED-8
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CANLF|Ensembl=ENSCAFG00000018970|UniProtKB=F1PXS6	Uncharacterized protein	ISS	http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00047	PDGF signaling pathway	P01162	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00004	Alzheimer disease-presenilin pathway	P00114	actin	CAEEL|WormBase=WBGene00000065|UniProtKB=P0DM42	Actin-3	IDA	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00036	Interleukin signaling pathway	P00965	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	PANTR|Ensembl=ENSPTRG00000016182|UniProtKB=H2QPQ2	C-X-C motif chemokine	ISS	10946576	gi	PTHR10179:SF47	C-X-C MOTIF CHEMOKINE 10
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00036	Interleukin signaling pathway	P00994	FKHRL1	BOVIN|Ensembl=ENSBTAG00000011234|UniProtKB=F1N4K5	Uncharacterized protein	ISS	14775847	gi	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00048	PI3 kinase pathway	P01179	PKB	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	TAS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01471	alpha-catenin	TAKRU|Ensembl=ENSTRUG00000002863|UniProtKB=H2S2N9	Uncharacterized protein	ISS	1768802	PubMed	PTHR18914:SF29	CATENIN ALPHA-2
P00024	Glycolysis	P00672	Phosphofructokinase-1	RAT|RGD=3311|UniProtKB=P30835	ATP-dependent 6-phosphofructokinase, liver type	RCA			PTHR13697:SF14	ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE, LIVER TYPE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	RAT|RGD=2740|UniProtKB=Q62645	Glutamate receptor ionotropic, NMDA 2D	ISS	14698601	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	RAT|RGD=2027|UniProtKB=P63269	Actin, gamma-enteric smooth muscle	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P05915	Opioid proenkephalin pathway	P05994	G-protein	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02734	Chorismate biosynthesis	P02873	Shikimate dehydrogenase	AQUAE|EnsemblGenome=aq_901|UniProtKB=O67049	Shikimate dehydrogenase (NADP(+))	ISS			PTHR21089:SF1	BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE/SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC
P00053	T cell activation	P01307	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00052	TGF-beta signaling pathway	P01284	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00030	Hypoxia response via HIF activation	P00819	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00009	Axon guidance mediated by netrin	P00366	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	CANLF|Ensembl=ENSCAFG00000019216|UniProtKB=P62872	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00049	Parkinson disease	P01211	ERK	MACMU|Ensembl=ENSMMUG00000008536|UniProtKB=F6WBZ5	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00019	Endothelin signaling pathway	P00591	PLCbeta	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04398	p53 pathway feedback loops 2	P04665	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000023046|UniProtKB=F6V829	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P04393	Ras Pathway	P04556	Raf	DANRE|ZFIN=ZDB-GENE-040805-1|UniProtKB=Q1LYG2	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	ECOLI|EcoGene=EG10193|UniProtKB=P16703	Cysteine synthase B	ISS			PTHR10314:SF100	CYSTEINE SYNTHASE B
P00022	General transcription by RNA polymerase I	P00657	TBP	MACMU|Ensembl=ENSMMUG00000019917|UniProtKB=F6SEF6	Uncharacterized protein	ISS	11988536	PubMed	PTHR10126:SF20	TATA-BOX-BINDING PROTEIN
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	MONDO|Ensembl=ENSMODG00000023174|UniProtKB=F7D7P2	Uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF197	CALMODULIN-LIKE PROTEIN 3
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	10644715	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00034	Integrin signalling pathway	P00944	Actin	PUCGT|EnsemblGenome=PGTG_05488|UniProtKB=E3K4I1	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00057	Wnt signaling pathway	P01428	Frizzled	HUMAN|HGNC=4044|UniProtKB=O60353	Frizzled-6	IDA	8717036	PubMed	PTHR11309:SF75	FRIZZLED-6
P00021	FGF signaling pathway	P00627	ERK1-2	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	IGI	11707292	PubMed	PTHR24055:SF330	SUBFAMILY NOT NAMED
P00037	Ionotropic glutamate receptor pathway	P01007	NR2B	MACMU|Ensembl=ENSMMUG00000019112|UniProtKB=F6T8S6	N-methyl D-aspartate receptor subtype 2B	ISS	14698601	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00029	Huntington disease	G01531	BDNF	DANRE|ZFIN=ZDB-GENE-000412-1|UniProtKB=Q6NZ01	Bdnf protein	IDA	11408619	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00017	DNA replication	P00537	RPA	ORYSJ|EnsemblGenome=OS02G0829100|UniProtKB=Q6K9U2	Replication protein A 32 kDa subunit A	ISS	21363455	PubMed	PTHR13989:SF29	SUBFAMILY NOT NAMED
P00046	Oxidative stress response	P01131	MKP5	MONDO|Ensembl=ENSMODG00000004672|UniProtKB=F6U725	Uncharacterized protein	ISS	11856337	PubMed	PTHR10159:SF299	DUAL SPECIFICITY PROTEIN PHOSPHATASE 10
P00006	Apoptosis signaling pathway	P00321	HSP70	DROME|FlyBase=FBgn0001216|UniProtKB=P29843	Heat shock 70 kDa protein cognate 1	ISS	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00019	Endothelin signaling pathway	P00566	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	12787066	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00005	Angiogenesis	P00223	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01457	GBeta	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IDA	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P02775	Salvage pyrimidine ribonucleotides	P03150	Uridine kinase	DANRE|ZFIN=ZDB-GENE-030131-7158|UniProtKB=Q7SYM0	Uridine-cytidine kinase 2-A	ISS			PTHR10285:SF70	URIDINE-CYTIDINE KINASE 2
P00010	B cell activation	P00383	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00029	Huntington disease	P00796	Kainate receptor	PANTR|Ensembl=ENSPTRG00000000543|UniProtKB=H2PYN8	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PHYPA|Gene=PHYPADRAFT_109052|UniProtKB=A9TZ58	Actin 5	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00052	TGF-beta signaling pathway	P01284	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	HUMAN|HGNC=4587|UniProtKB=Q14957	Glutamate receptor ionotropic, NMDA 2C	IC	14698601	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00041	Metabotropic glutamate receptor group I pathway	P01062	mGluR1	HUMAN|HGNC=4593|UniProtKB=Q13255	Metabotropic glutamate receptor 1	ISS	8314195	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P04393	Ras Pathway	P04546	GSK3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	IDA	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8972|UniProtKB=O00750	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00052	TGF-beta signaling pathway	P01275	P38	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	TAS	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00053	T cell activation	P01310	Lck	RAT|RGD=2994|UniProtKB=Q01621	Proto-oncogene tyrosine-protein kinase LCK	ISS	11078745	PubMed	PTHR24418:SF39	TYROSINE-PROTEIN KINASE LCK
P00004	Alzheimer disease-presenilin pathway	P00154	Notch fragment	CANLF|Ensembl=ENSCAFG00000019633|UniProtKB=F1PDC7	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	MOUSE|MGI=MGI=98355|UniProtKB=Q02384	Son of sevenless homolog 2	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00056	VEGF signaling pathway	P01425	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	22246731	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05913	Enkephalin release	P05972	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01451	Galpha	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00018	EGF receptor signaling pathway	P00551	Akt	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	IXOSC|EnsemblGenome=ISCW017133|UniProtKB=B7PA92	Beta tubulin	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00018	EGF receptor signaling pathway	P00565	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00006	Apoptosis signaling pathway	P00310	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00046	Oxidative stress response	P01129	JNK1/2	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00047	PDGF signaling pathway	P01161	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	3550433	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01167	Ets	MACMU|Ensembl=ENSMMUG00000020706|UniProtKB=F6PU72	Uncharacterized protein	ISS	15699632	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00009	Axon guidance mediated by netrin	P00364	cdc42	TAKRU|Ensembl=ENSTRUG00000013411|UniProtKB=H2UB84	Uncharacterized protein	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P06212	DPP-SCW signaling pathway	P06271	MAD	DROME|FlyBase=FBgn0011648|UniProtKB=P42003	Protein mothers against dpp	IGI	12736218	PubMed	PTHR13703:SF40	PROTEIN MOTHERS AGAINST DPP
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00021	FGF signaling pathway	P00624	14-3-3	TAKRU|Ensembl=ENSTRUG00000004697|UniProtKB=H2SFG7	Uncharacterized protein	ISS	22165492	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00010	B cell activation	P00386	Calcineurin	NEUCR|EnsemblGenome=EFNCRG00000003474|UniProtKB=Q05681	Serine/threonine-protein phosphatase 2B catalytic subunit	IDA	12015605	PubMed	PTHR11668:SF118	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED
P00053	T cell activation	P01300	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01435	SWI/SNF	BOVIN|Ensembl=ENSBTAG00000014372|UniProtKB=Q17QK5	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3	ISS	11532957	PubMed	PTHR13844:SF5	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D MEMBER 3
P05917	Opioid proopiomelanocortin pathway	P06008	ACTH	XENTR|Xenbase=XB-GENE-483703|UniProtKB=Q5M8F2	Proopiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	12805548	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00041	Metabotropic glutamate receptor group I pathway	P01062	mGluR1	PANTR|Ensembl=ENSPTRG00000018684|UniProtKB=C7G3M7	Glutamate receptor, metabotropic 1	ISS	12488551	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00012	Cadherin signaling pathway	P00474	Wnt	RAT|RGD=1306312|UniProtKB=D4A9D7	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF92	PROTEIN WNT-8A
P00010	B cell activation	P00367	NFAT	RAT|RGD=1308692|UniProtKB=A0A0G2JTY4	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 (Predicted), isoform CRA_b	ISS	9462517	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P02747	Histidine biosynthesis	P02992	Imidazol glycerol phosphate synthase	DEIRA|EnsemblGenome=DR_0732|UniProtKB=Q9RWD7	Imidazole glycerol phosphate synthase subunit HisF	ISS			PTHR21235:SF2	IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF
P00057	Wnt signaling pathway	P01428	Frizzled	MOUSE|MGI=MGI=2136761|UniProtKB=Q8BKG4	Frizzled-10	ISS	8717036	PubMed	PTHR11309:SF86	FRIZZLED-10
P00018	EGF receptor signaling pathway	P00545	JNK1-3	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IGI	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	MOUSE|MGI=MGI=95818|UniProtKB=Q61626	Glutamate receptor ionotropic, kainate 5	ISS	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	RAT|RGD=3570|UniProtKB=P49803	Regulator of G-protein signaling 7	IDA	8756726	PubMed	PTHR10845:SF26	REGULATOR OF G-PROTEIN SIGNALING 7
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000003399|UniProtKB=H2Q383	Phosphoinositide-3-kinase, class 2, alpha polypeptide	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01438	PP2A	ORNAN|Ensembl=ENSOANG00000013519|UniProtKB=F7E5M4	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	EMENI|EnsemblGenome=CADANIAG00002670|UniProtKB=Q5BH99	G-protein beta subunit [Source:UniProtKB/TrEMBLAcc:O74214]	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00006	Apoptosis signaling pathway	P00321	HSP70	MOUSE|MGI=MGI=96243|UniProtKB=P17156	Heat shock-related 70 kDa protein 2	ISS	12150907	PubMed	PTHR19375:SF216	HEAT SHOCK-RELATED 70 KDA PROTEIN 2
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00048	PI3 kinase pathway	P01192	p110	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02734	Chorismate biosynthesis	P02868	Chorismate synthase	NEUCR|EnsemblGenome=EFNCRG00000006554|UniProtKB=Q12640	Chorismate synthase	ISS			PTHR21085:SF0	CHORISMATE SYNTHASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00014	Cholesterol biosynthesis	P00494	Squalene monooxygenas	PANTR|Ensembl=ENSPTRG00000020572|UniProtKB=H2QWP8	Squalene epoxidase	ISS			PTHR10835:SF0	SQUALENE MONOOXYGENASE
P00018	EGF receptor signaling pathway	P00552	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00017	DNA replication	P00534	PCNA	PYRAE|EnsemblGenome=PAE0720|UniProtKB=Q8ZYL6	DNA polymerase sliding clamp 2	ISS	21664397	PubMed	PTHR11352:SF0	PROLIFERATING CELL NUCLEAR ANTIGEN
P00030	Hypoxia response via HIF activation	P00819	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02744	Fructose galactose metabolism	P02964	Hexose 1-P uridyltransferase	MACMU|Ensembl=ENSMMUG00000020789|UniProtKB=F7HA02	Galactose-1-phosphate uridylyltransferase	ISS	1610789	PubMed	PTHR11943:SF1	GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE
P00021	FGF signaling pathway	P00642	MEK1-2	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00021	FGF signaling pathway	P00645	Rac	ENTHI|EnsemblGenome=EHI_129750|UniProtKB=C4M5Q7	Rho family GTPase	IGI	9601102	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00022	General transcription by RNA polymerase I	P00657	TBP	YEAST|SGD=S000000950|UniProtKB=P13393	TATA-box-binding protein	ISS	11988536	PubMed	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	TAS	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00004	Alzheimer disease-presenilin pathway	P00169	LRP N-terminal fragment	MONDO|Ensembl=ENSMODG00000002847|UniProtKB=F7B627	Uncharacterized protein (Fragment)	ISS	11907044	PubMed	PTHR44025:SF7	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B
P06587	Nicotine pharmacodynamics pathway	P06608	DDC	PANTR|Ensembl=ENSPTRG00000019189|UniProtKB=H2QUK8	Uncharacterized protein	ISS	7567987	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00054	Toll receptor signaling pathway	P01338	IkappaB	MACMU|Ensembl=ENSMMUG00000020374|UniProtKB=F6UMS2	NF-kappa-B inhibitor alpha	ISS	10811867	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00004	Alzheimer disease-presenilin pathway	P00114	actin	BOVIN|Ensembl=ENSBTAG00000006189|UniProtKB=P63258	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MOUSE|MGI=MGI=95815|UniProtKB=P39087	Glutamate receptor ionotropic, kainate 2	ISS	11319238	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00018	EGF receptor signaling pathway	P00557	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS	15470041	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00041	Metabotropic glutamate receptor group I pathway	P01062	mGluR1	MACMU|Ensembl=ENSMMUG00000016428|UniProtKB=F7GU00	Metabotropic glutamate receptor 1 isoform alpha	ISS	8314195	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	IDA	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=2446084|UniProtKB=Q8R5M2	Protein Wnt-9a	IDA	8717036	PubMed	PTHR12027:SF75	PROTEIN WNT-9A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	PANTR|Ensembl=ENSPTRG00000015787|UniProtKB=H2QP14	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00030	Hypoxia response via HIF activation	P00818	HIF-1alpha	PANTR|Ensembl=ENSPTRG00000006419|UniProtKB=H2Q8F3	Uncharacterized protein	ISS	14526383	PubMed	PTHR23043:SF7	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA
P00029	Huntington disease	P00780	Microtubule	CHLRE|EnsemblGenome=CHLREDRAFT_129868|UniProtKB=A8IXZ0	Beta tubulin 1	IDA	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	TAS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	CHICK|Ensembl=ENSGALG00000002859|UniProtKB=F6UBD2	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00019	Endothelin signaling pathway	P00591	PLCbeta	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	RAT|RGD=621665|UniProtKB=Q9JHX0	Regulator of G-protein signaling 2	ISS	8756726	PubMed	PTHR10845:SF43	REGULATOR OF G-PROTEIN SIGNALING 2
P00018	EGF receptor signaling pathway	P00565	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01471	alpha-catenin	CHICK|Ensembl=ENSGALG00000002447|UniProtKB=E1C7M7	Uncharacterized protein	ISS	10456847	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	MOUSE|MGI=MGI=1354739|UniProtKB=Q9Z2H1	Regulator of G-protein signaling 11	IDA	8756726	PubMed	PTHR10845:SF144	REGULATOR OF G-PROTEIN SIGNALING 11
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00048	PI3 kinase pathway	P01192	p110	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CAEBR|Gene=CBG02162|UniProtKB=A8WS33	Protein CBG02162	ISS	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00005	Angiogenesis	P00199	JNKK1	CANLF|Ensembl=ENSCAFG00000017851|UniProtKB=F1PBB6	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_114976|UniProtKB=C3YP58	Putative uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00054	Toll receptor signaling pathway	P01375	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	PANTR|Ensembl=ENSPTRG00000006890|UniProtKB=H2Q943	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00010	B cell activation	P00402	Jnk	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02771	Pyrimidine Metabolism	P03130	Cytidine Deaminase	PANTR|Ensembl=ENSPTRG00000000290|UniProtKB=H2PY87	Cytidine deaminase	ISS	12844405	PubMed	PTHR11644:SF2	CYTIDINE DEAMINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	CAEBR|Gene=CBG01097|UniProtKB=A8WPJ8	Protein CBR-CMD-1	ISS			PTHR23050:SF236	CALMODULIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=1351343|UniProtKB=Q5NCH9	Metabotropic glutamate receptor 6	ISS	12488551	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00057	Wnt signaling pathway	P01451	Galpha	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00048	PI3 kinase pathway	P01182	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00021	FGF signaling pathway	P00632	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	1689310	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00012	Cadherin signaling pathway	P00475	Frizzled	BOVIN|Ensembl=ENSBTAG00000020957|UniProtKB=F1MGM1	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF126	FRIZZLED-5
P00029	Huntington disease	P00780	Microtubule	RAT|RGD=1309427|UniProtKB=Q3KRE8	Tubulin beta-2B chain	IDA	9454836	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	ORYSJ|EnsemblGenome=OS03G0207300|UniProtKB=Q10Q71	Casein kinase II, alpha chain, putative, expressed	IDA	10617630	PubMed	PTHR24054:SF35	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00551	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	RAT|RGD=2959|UniProtKB=P48550	G protein-activated inward rectifier potassium channel 2	ISS	2433589	PubMed	PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DANRE|ZFIN=ZDB-GENE-050417-267|UniProtKB=F1QUN8	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF263	ACTIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	9395335	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=2683547|UniProtKB=Q4KWH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1	ISS	12860966	PubMed	PTHR10336:SF51	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-1
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00056	VEGF signaling pathway	P01407	Erk	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	P04609	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00060	Ubiquitin proteasome pathway	P01490	E3	HUMAN|HGNC=13478|UniProtKB=Q7Z3V4	Ubiquitin-protein ligase E3B	ISS			PTHR11254:SF352	UBIQUITIN-PROTEIN LIGASE E3B
P00045	Notch signaling pathway	P01116	Delta	PANTR|Ensembl=ENSPTRG00000006726|UniProtKB=H2RDH4	Delta-like 1 homolog	ISS			PTHR24052:SF11	PROTEIN DELTA HOMOLOG 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MONDO|Ensembl=ENSMODG00000023940|UniProtKB=F6RFW8	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00057	Wnt signaling pathway	P01435	SWI/SNF	SCHPO|PomBase=SPAC17G6.10|UniProtKB=O13788	SWI/SNF and RSC complexes subunit ssr1	ISS	11532957	PubMed	PTHR12802:SF41	BRAHMA ASSOCIATED PROTEIN 155 KDA
P00053	T cell activation	P01316	MHC-antigen	CHICK|Ensembl=ENSGALG00000002160|UniProtKB=P21611	Beta-2-microglobulin	IPI			PTHR19944:SF62	BETA-2-MICROGLOBULIN
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IGI	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05913	Enkephalin release	P05977	G-Protein (s)	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	RCA	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00057	Wnt signaling pathway	P01454	betaTrCP	ORNAN|Ensembl=ENSOANG00000007791|UniProtKB=F6YUQ2	Uncharacterized protein	ISS	12628165	PubMed	PTHR44038:SF1	F-BOX/WD REPEAT-CONTAINING PROTEIN 11
P00029	Huntington disease	P00807	Actin	CHICK|Ensembl=ENSGALG00000011086|UniProtKB=P68139	Actin, alpha skeletal muscle	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05731	GABA-B receptor II signaling	P05752	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	88234494	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	RAT|RGD=1304556|UniProtKB=P63259	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IDA	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	XENTR|Xenbase=XB-GENE-1004371|UniProtKB=F6R882	Uncharacterized protein	ISS	2433589	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04398	p53 pathway feedback loops 2	P04651	Ras	DAPPU|EnsemblGenome=DAPPUDRAFT_301818|UniProtKB=E9I1I7	Putative uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DICDI|dictyBase=DDB_G0269234|UniProtKB=P07830	Major actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	HUMAN|HGNC=132|UniProtKB=P60709	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00034	Integrin signalling pathway	P00944	Actin	CANLF|Ensembl=ENSCAFG00000016020|UniProtKB=O18840	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04395	Vasopressin synthesis	P04597	Signal Peptide	HUMAN|HGNC=8528|UniProtKB=P01178	Oxytocin-neurophysin 1	ISS	6717565	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00029	Huntington disease	P00786	ARF	TRYB2|Gene=Tb09.211.4470|UniProtKB=Q38D64	ADP-ribosylation factor, putative	ISS	12932731	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00016	Cytoskeletal regulation by Rho GTPase	P00507	Rho	CHICK|Ensembl=ENSGALG00000016485|UniProtKB=O93468	GTP-binding protein	ISS	13679859	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00021	FGF signaling pathway	P00643	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00475	Frizzled	DROME|FlyBase=FBgn0016797|UniProtKB=Q9VVX3	Frizzled-2	IDA	8717036	PubMed	PTHR11309:SF90	FRIZZLED-8
P00029	Huntington disease	P00786	ARF	LEIMA|EnsemblGenome=LmjF.04.0480|UniProtKB=Q9U0T6	Putative ADP-ribosylation factor	IPI	12932731	PubMed	PTHR11711:SF292	SUBFAMILY NOT NAMED
P00010	B cell activation	P00391	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00053	T cell activation	P01300	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IDA	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00973	PKB	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	PSEAE|EnsemblGenome=PA4189|UniProtKB=Q9HWJ2	Probable aldehyde dehydrogenase	IC			PTHR11699:SF211	ALDEHYDE DEHYDROGENASE 5, MITOCHONDRIAL
P00057	Wnt signaling pathway	P01445	Cerebus	MOUSE|MGI=MGI=1201414|UniProtKB=O55233	Cerberus	IDA	10067895	PubMed	PTHR15273:SF4	CERBERUS
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	TAS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	ANOGA|EnsemblGenome=AGAP003094|UniProtKB=Q7QBM3	AGAP003094-PA	ISS			PTHR12595:SF6	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 9
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MOUSE|MGI=MGI=88396|UniProtKB=P12657	Muscarinic acetylcholine receptor M1	IDA	12915051	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	DANRE|ZFIN=ZDB-GENE-020125-3|UniProtKB=E7F1V8	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00890	ELK	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	ISS	11050086	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00048	PI3 kinase pathway	P01199	Galpha	HUMAN|HGNC=4394|UniProtKB=P19087	Guanine nucleotide-binding protein G(t) subunit alpha-2	IC			PTHR10218:SF68	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT ALPHA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00049	Parkinson disease	P01208	Hsp70	XENTR|Xenbase=XB-GENE-5842877|UniProtKB=F6TJ80	Uncharacterized protein	ISS	12150907	PubMed	PTHR19375:SF310	HEAT SHOCK COGNATE 71 KDA PROTEIN
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00059	p53 pathway	P04609	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00059	p53 pathway	P04625	Cdk2	CANLF|Ensembl=ENSCAFG00000000082|UniProtKB=E2QW70	Uncharacterized protein	ISS	15660127	PubMed	PTHR24056:SF254	CYCLIN-DEPENDENT KINASE 2
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00056	VEGF signaling pathway	P01411	Ras	CHICK|Ensembl=ENSGALG00000014033|UniProtKB=E1BTS2	Uncharacterized protein	ISS	99084794	PubMed	PTHR24070:SF186	GTPASE KRAS
P00019	Endothelin signaling pathway	P00568	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	89186920	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00034	Integrin signalling pathway	P00942	Fyn	DANRE|ZFIN=ZDB-GENE-030903-5|UniProtKB=Q6EWH2	Tyrosine-protein kinase fyna	ISS	11078745	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00029	Huntington disease	P00790	beta-Tubulin	LEIMA|EnsemblGenome=LmjF.33.0792|UniProtKB=Q4Q4C4	Beta tubulin	TAS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	XENTR|Xenbase=XB-GENE-480347|UniProtKB=Q6P640	Actin, alpha cardiac muscle 1	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008422|UniProtKB=F6VUT7	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00019	Endothelin signaling pathway	P00577	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00021	FGF signaling pathway	P00633	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04393	Ras Pathway	P04557	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00018	EGF receptor signaling pathway	P00564	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	10802295	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	14564011	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04397	p53 pathway by glucose deprivation	P04641	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	HUMAN|HGNC=4572|UniProtKB=P42262	Glutamate receptor 2	ISS	Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891	Website	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00029	Huntington disease	P00790	beta-Tubulin	CHICK|Ensembl=ENSGALG00000027684|UniProtKB=P09653	Tubulin beta-5 chain	TAS	12932731	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00053	T cell activation	P01332	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00539	14-3-3	XENTR|Xenbase=XB-GENE-970616|UniProtKB=Q6P4Z5	14-3-3 protein zeta	ISS	12861023	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	IGI	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00005	Angiogenesis	P00256	PLC-gamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12860966	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00018	EGF receptor signaling pathway	P00560	Raf-1	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IGI	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	TAS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	RCA	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MOUSE|MGI=MGI=1933206|UniProtKB=A2AIR5	Protein Grin3a	ISS	14698601	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00009	Axon guidance mediated by netrin	P00363	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00049	Parkinson disease	P01236	Casein kinase II	XENTR|Xenbase=XB-GENE-487069|UniProtKB=F6RN85	Uncharacterized protein	ISS	10617630	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P00018	EGF receptor signaling pathway	P00547	PP2A	HUMAN|HGNC=9312|UniProtKB=Q14738	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	ISS	12110603	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00056	VEGF signaling pathway	P01411	Ras	CANLF|Ensembl=ENSCAFG00000009532|UniProtKB=F1PHV7	Uncharacterized protein	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	ORYSJ|EnsemblGenome=OS02G0834000|UniProtKB=Q6EP31	Rac-like GTP-binding protein 5	ISS			PTHR24072:SF194	RAC-LIKE GTP-BINDING PROTEIN ARAC4-RELATED
P02746	Heme biosynthesis	P02982	Protoheme IX farnesyl transferase	BACSU|EnsemblGenome=BSU14880|UniProtKB=P24009	Protoheme IX farnesyltransferase 2	ISS			PTHR43448:SF2	PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL
P00056	VEGF signaling pathway	P01407	Erk	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	MONDO|Ensembl=ENSMODG00000016078|UniProtKB=F7A567	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000013197|UniProtKB=Q9XT96	Presenilin-2	IDA	9332390	PubMed	PTHR10202:SF13	PRESENILIN-2
P00045	Notch signaling pathway	P01102	Sel 10	CAEEL|WormBase=WBGene00004767|UniProtKB=Q93794	F-box/WD repeat-containing protein sel-10	TAS	9637676	PubMed	PTHR44007:SF6	F-BOX/WD REPEAT-CONTAINING PROTEIN 7
P00010	B cell activation	P00391	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	TAS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00021	FGF signaling pathway	P00648	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05913	Enkephalin release	P05978	AC	RAT|RGD=619966|UniProtKB=F1LQT1	Adenylate cyclase 7	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	HUMAN|HGNC=7572|UniProtKB=Q9UKX2	Myosin-2	ISS	89264452	PubMed	PTHR13140:SF385	MYOSIN-2
P06664	Gonadotropin-releasing hormone receptor pathway	P06786	ERK1/2	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	RCA	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00048	PI3 kinase pathway	P01177	P110ACT	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00983	Raf	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS	12068308	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1354946|UniProtKB=Q61532	Mitogen-activated protein kinase 6	IDA	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00807	Actin	CHICK|Ensembl=ENSGALG00000028749|UniProtKB=Q5ZMQ2	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00057	Wnt signaling pathway	P01447	Dishevelled	MOUSE|MGI=MGI=108100|UniProtKB=Q61062	Segment polarity protein dishevelled homolog DVL-3	ISS	11212302	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	1426252	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MOUSE|MGI=MGI=87905|UniProtKB=P68033	Actin, alpha cardiac muscle 1	IC	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05730	Endogenous cannabinoid signaling	P05748	mGluR	MOUSE|MGI=MGI=1351338|UniProtKB=P97772	Metabotropic glutamate receptor 1	ISS	7476890	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P02762	Pentose phosphate pathway	P03079	Hexokinase	MOUSE|MGI=MGI=2384910|UniProtKB=Q91W97	Putative hexokinase HKDC1	RCA			PTHR19443:SF28	HEXOKINASE HKDC1-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04393	Ras Pathway	P04578	Rho	BOVIN|Ensembl=ENSBTAG00000046054|UniProtKB=Q3ZBW5	Rho-related GTP-binding protein RhoB	ISS	13679859	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00047	PDGF signaling pathway	P01148	Grb2	PANTR|Ensembl=ENSPTRG00000014404|UniProtKB=H2QLR1	Uncharacterized protein	ISS	51702266	gi	PTHR24418:SF299	GRB2-RELATED ADAPTER PROTEIN 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000000843|UniProtKB=H2QZN8	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00036	Interleukin signaling pathway	P00983	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	TAS	P04049	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06706	AdipoR1/R2	MOUSE|MGI=MGI=1919924|UniProtKB=Q91VH1	Adiponectin receptor protein 1	RCA			PTHR20855:SF40	ADIPONECTIN RECEPTOR PROTEIN 1
P00053	T cell activation	P01312	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	ISS	10395662	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00019	Endothelin signaling pathway	P00585	ECE1-3	PANTR|Ensembl=ENSPTRG00000000298|UniProtKB=H2R1S0	Endothelin converting enzyme 1	ISS	94340737	PubMed	PTHR11733:SF130	ENDOTHELIN-CONVERTING ENZYME 1
P00038	JAK/STAT signaling pathway	P01031	PIAS	CANLF|Ensembl=ENSCAFG00000011319|UniProtKB=E2R2U8	Uncharacterized protein	ISS	8682149	PubMed	PTHR10782:SF10	E3 SUMO-PROTEIN LIGASE PIAS3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00019	Endothelin signaling pathway	P00571	Pro ET1-4	MACMU|Ensembl=ENSMMUG00000007263|UniProtKB=F7FGG2	Preproendothelin-1	ISS	12907686	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=894282|UniProtKB=O08858	Somatostatin receptor type 5	IDA	12181435	PubMed	PTHR24229:SF20	SOMATOSTATIN RECEPTOR TYPE 5
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	CANLF|Ensembl=ENSCAFG00000013159|UniProtKB=E2RAF3	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF79	FRIZZLED-9
P00012	Cadherin signaling pathway	P00470	F-actin	MOUSE|MGI=MGI=104589|UniProtKB=P63268	Actin, gamma-enteric smooth muscle	IC	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IC	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04395	Vasopressin synthesis	P04598	Pro-Vasopressin	TAKRU|Ensembl=ENSTRUG00000015631|UniProtKB=H2USP0	Uncharacterized protein	ISS			PTHR11681:SF14	SUBFAMILY NOT NAMED
P04393	Ras Pathway	P04552	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00046	Oxidative stress response	P01124	Myc	MACMU|Ensembl=ENSMMUG00000014601|UniProtKB=B8XIA5	Myc proto-oncogene protein	ISS	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	PANTR|Ensembl=ENSPTRG00000010386|UniProtKB=H2QF61	Tyrosine-protein kinase receptor	ISS	6754360	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00052	TGF-beta signaling pathway	P01284	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	15528206	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00034	Integrin signalling pathway	P00925	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00018	EGF receptor signaling pathway	P00539	14-3-3	SCHMA|EnsemblGenome=Smp_034840|UniProtKB=G4V8A9	14-3-3 epsilon	IGI	21099905	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	PANTR|Ensembl=ENSPTRG00000024064|UniProtKB=H2R3R2	Synaptotagmin I	ISS	SYT1_BOVIN	SPACC	PTHR10024:SF239	SYNAPTOTAGMIN-1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00012	Cadherin signaling pathway	P00470	F-actin	DANRE|ZFIN=ZDB-GENE-000322-1|UniProtKB=Q9I8V1	Actin, alpha 1, skeletal muscle	IC	14684598	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CAEEL|WormBase=WBGene00006454|UniProtKB=G5EEN8	AEX-4	IC			PTHR19305:SF10	AEX-4
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01145	c-fos	MACMU|Ensembl=ENSMMUG00000010574|UniProtKB=A5A6H2	C-fos	ISS	11724916	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00006	Apoptosis signaling pathway	P00269	MAPK	ORYSJ|EnsemblGenome=OS06G0154500|UniProtKB=Q84UI5	Mitogen-activated protein kinase 1	ISS	10514528	PubMed	PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	CAEEL|WormBase=WBGene00003401|UniProtKB=P39745	Mitogen-activated protein kinase mpk-1	ISS	94131269	PubMed	PTHR24055:SF341	MITOGEN-ACTIVATED PROTEIN KINASE ERK-A
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PRIPA|Gene=PPA23459|UniProtKB=H3FMF2	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00052	TGF-beta signaling pathway	P01275	P38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	TAS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00049	Parkinson disease	P01227	20S proteasome	ANOGA|EnsemblGenome=AGAP011423|UniProtKB=Q7Q306	Proteasome subunit beta type	TAS	12859888	PubMed	PTHR11599:SF44	AT05866P-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=1310903|UniProtKB=D4A978	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF33	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-3
P00021	FGF signaling pathway	P00623	FGF	MONDO|Ensembl=ENSMODG00000015116|UniProtKB=F7ELZ5	Fibroblast growth factor	ISS	9232594	PubMed	PTHR11486:SF17	FIBROBLAST GROWTH FACTOR 12
P00005	Angiogenesis	P00199	JNKK1	CHICK|Ensembl=ENSGALG00000001001|UniProtKB=F1P3T1	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00047	PDGF signaling pathway	P01156	PDGF receptor B	MOUSE|MGI=MGI=97531|UniProtKB=P05622	Platelet-derived growth factor receptor beta	RCA			PTHR24416:SF53	PLATELET-DERIVED GROWTH FACTOR RECEPTOR BETA
P00034	Integrin signalling pathway	P00915	PTP-PEST	MOUSE|MGI=MGI=104673|UniProtKB=P35831	Tyrosine-protein phosphatase non-receptor type 12	IDA	8887669	PubMed	PTHR19134:SF283	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 12
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	IC	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00053	T cell activation	P01294	NFAT	PANTR|Ensembl=ENSPTRG00000013628|UniProtKB=H2R4F5	Uncharacterized protein	ISS	12015605	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12429574	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	10074940	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00049	Parkinson disease	P01242	Casein kinase I	ORYSJ|EnsemblGenome=OS01G0772600|UniProtKB=Q8S1J0	Os01g0772600 protein	IDA	11437445	PubMed	PTHR11909:SF153	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	TAKRU|Ensembl=ENSTRUG00000003591|UniProtKB=H2S7Q1	Uncharacterized protein	IDA	11781138	PubMed	PTHR24248:SF25	ALPHA-2C ADRENERGIC RECEPTOR
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00005	Angiogenesis	P00245	Rac	CAEEL|WormBase=WBGene00012203|UniProtKB=Q23130	Rho GTPase Activating protein	ISS			PTHR23176:SF0	RHO GTPASE-ACTIVATING PROTEIN 68F
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IPI	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00627	ERK1-2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05912	Dopamine receptor mediated signaling pathway	P05961	DOPA decarb.	PANTR|Ensembl=ENSPTRG00000019189|UniProtKB=H2QUK8	Uncharacterized protein	ISS	7567987	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	1846707	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00906	Rap1	XENTR|Xenbase=XB-GENE-479951|UniProtKB=F6YT39	Uncharacterized protein	ISS	8576107	PubMed	PTHR24070:SF221	RAS-RELATED PROTEIN RAP-2A
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00010	B cell activation	P00401	jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00003	Alzheimer disease-amyloid secretase pathway	P00090	MDC9	MOUSE|MGI=MGI=105376|UniProtKB=Q61072	Disintegrin and metalloproteinase domain-containing protein 9	IDA	10510302	PubMed	PTHR11905:SF136	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 9
P00018	EGF receptor signaling pathway	P00559	MEK1-2	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01087	CAT	ANOGA|EnsemblGenome=AGAP002370|UniProtKB=Q7QBZ0	AGAP002370-PA (Fragment)	IC	97225904	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P02772	Pyruvate metabolism	P03141	Citrate Synthetase	STRCO|Gene=CAB95899|UniProtKB=Q9K3V6	Putative citrate synthase	ISS	12000953	PubMed	PTHR11739:SF23	SUBFAMILY NOT NAMED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	TAS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	ARATH|TAIR=AT1G55970|UniProtKB=Q9LG11	Histone acetyltransferase HAC4	ISS	10769018	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00046	Oxidative stress response	P01134	cPLA2	CANLF|Ensembl=ENSCAFG00000013778|UniProtKB=F6UQ33	Phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	IDA	15521358	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00036	Interleukin signaling pathway	P00965	ERK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	IDA	8663524	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P02748	Isoleucine biosynthesis	P02995	Threonine dehydratase	CAEBR|Gene=CBG00666|UniProtKB=A8WNC1	Protein CBG00666	ISS			PTHR43419:SF10	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Ensembl=ENSBTAG00000011953|UniProtKB=P05131	cAMP-dependent protein kinase catalytic subunit beta	ISS	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=2685045|UniProtKB=E9QAN8	Protein Pik3c2b	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PHYPA|Gene=PHYPADRAFT_172686|UniProtKB=A9TYG6	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00053	T cell activation	P01323	I kappa B	MOUSE|MGI=MGI=104741|UniProtKB=Q9Z1E3	NF-kappa-B inhibitor alpha	ISS	10811867	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00047	PDGF signaling pathway	P01142	p90RSK	BOVIN|Ensembl=ENSBTAG00000017639|UniProtKB=F1MZW8	Ribosomal protein S6 kinase	ISS	2779569	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00025	Hedgehog signaling pathway	P00685	Smoothened	PANTR|Ensembl=ENSPTRG00000019680|UniProtKB=H2QVC7	Uncharacterized protein	ISS	942251	PubMed	PTHR11309:SF35	SMOOTHENED HOMOLOG
P00053	T cell activation	P01332	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	TAKRU|Ensembl=ENSTRUG00000010272|UniProtKB=H2TMF1	Inosine-5'-monophosphate dehydrogenase	ISS			PTHR11911:SF121	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2
P00053	T cell activation	P01336	Jnk	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	CANLF|Ensembl=ENSCAFG00000007357|UniProtKB=F1PPK6	Receptor protein serine/threonine kinase	ISS	10683140	PubMed	PTHR23255:SF22	ACTIVIN RECEPTOR TYPE-1B
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	DANRE|ZFIN=ZDB-GENE-040426-2385|UniProtKB=Q6P3K7	Casein kinase I isoform delta-B	ISS	10617630	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DROME|FlyBase=FBgn0001105|UniProtKB=P26308	Guanine nucleotide-binding protein subunit beta-1	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00045	Notch signaling pathway	P01114	Ntm	HUMAN|HGNC=7882|UniProtKB=Q04721	Neurogenic locus notch homolog protein 2	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	HUMAN|HGNC=4401|UniProtKB=O14775	Guanine nucleotide-binding protein subunit beta-5	RCA	9754712	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00005	Angiogenesis	P00219	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00005	Angiogenesis	P00203	Erk	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00629	PP2A	SCHMA|EnsemblGenome=Smp_165490|UniProtKB=C1LZY9	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	MOUSE|MGI=MGI=95823|UniProtKB=Q03391	Glutamate receptor ionotropic, NMDA 2D	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00054	Toll receptor signaling pathway	P01369	MKK1	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00056	VEGF signaling pathway	P01425	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00023	General transcription regulation	P00664	TFIIH complex	RAT|RGD=1308225|UniProtKB=A0A0G2JWQ0	Protein Gtf2h1	ISS			PTHR12856:SF0	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	MACMU|Gene=CHRM1|UniProtKB=P56489	Muscarinic acetylcholine receptor M1	ISS	12181435	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00905	PTEN	XENTR|Xenbase=XB-GENE-491433|UniProtKB=B1H2U0	Pten protein	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00013	Cell cycle	P00480	Proteasome	BOVIN|Ensembl=ENSBTAG00000021461|UniProtKB=Q2KJ46	26S proteasome non-ATPase regulatory subunit 3	ISS	4506229	gi	PTHR10758:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3
P02754	Methylcitrate cycle	P03028	Aconitase	NEUCR|EnsemblGenome=EFNCRG00000000532|UniProtKB=Q7SGE5	Aconitate hydratase	ISS			PTHR21349:SF0	39S RIBOSOMAL PROTEIN L21, MITOCHONDRIAL
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	BOVIN|Ensembl=ENSBTAG00000047062|UniProtKB=G3MX13	Uncharacterized protein	ISS	11907044	PubMed	PTHR44062:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 3
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BOVIN|Ensembl=ENSBTAG00000003043|UniProtKB=P63212	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-481945|UniProtKB=F7DVL1	Protein kinase C (Fragment)	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00025	Hedgehog signaling pathway	P00682	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	ISS	91298951	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00054	Toll receptor signaling pathway	P01351	TLR2,4,7	MACMU|Ensembl=ENSMMUG00000009112|UniProtKB=F7HU26	Toll-like receptor 4	ISS			PTHR44568:SF1	TOLL-LIKE RECEPTOR 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00839	SHIP	PANTR|Ensembl=ENSPTRG00000004031|UniProtKB=H2Q4C6	Inositol polyphosphate phosphatase-like 1	ISS	12145149	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00019	Endothelin signaling pathway	P00570	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00059	p53 pathway	P04633	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P06211	BMP/activin signaling pathway-drosophila	P06251	BMP/activin orthologous ligand	DROME|FlyBase=FBgn0005590|UniProtKB=P54631	Protein screw	RCA	7958918	PubMed	PTHR11848:SF54	PROTEIN 60A-RELATED
P06959	CCKR signaling map	G06986	CCND1	HUMAN|HGNC=1582|UniProtKB=P24385	G1/S-specific cyclin-D1	RCA	17185632	PubMed	PTHR10177:SF67	G1/S-SPECIFIC CYCLIN-D1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00012	Cadherin signaling pathway	P00470	F-actin	PHYPA|Gene=PHYPADRAFT_225906|UniProtKB=A9TVP1	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00046	Oxidative stress response	P01129	JNK1/2	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	TAS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	HUMAN|HGNC=2460|UniProtKB=P67870	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00024	Glycolysis	P00679	Aldolase	BOVIN|Ensembl=ENSBTAG00000012927|UniProtKB=A6QLL8	Fructose-bisphosphate aldolase	ISS	6086339	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	8011337	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00018	EGF receptor signaling pathway	P00539	14-3-3	MOUSE|MGI=MGI=109194|UniProtKB=P68510	14-3-3 protein eta	IGI	14593000	PubMed	PTHR18860:SF16	14-3-3 PROTEIN ETA
P00034	Integrin signalling pathway	P00931	Integrin beta	PANTR|Ensembl=ENSPTRG00000009653|UniProtKB=H2QDV9	Integrin beta	ISS	3487386	PubMed	PTHR10082:SF42	INTEGRIN BETA-4
P00049	Parkinson disease	P01211	ERK	CHLRE|EnsemblGenome=CHLREDRAFT_193901|UniProtKB=Q9FXT7	Mitogen-activated protein kinase	IDA			PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00018	EGF receptor signaling pathway	P00552	Ras	CANLF|Ensembl=ENSCAFG00000007541|UniProtKB=E2QWU5	Uncharacterized protein	ISS			PTHR24070:SF268	RAS-RELATED PROTEIN M-RAS
P00021	FGF signaling pathway	P00640	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	14670845	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05918	p38 MAPK pathway	P06025	SRF	PANTR|Ensembl=ENSPTRG00000018189|UniProtKB=H2QT21	Uncharacterized protein	ISS	15170389	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	HUMAN|HGNC=9060|UniProtKB=P51178	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	ISS	12860966	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00005	Angiogenesis	P00203	Erk	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CHICK|Gene=CHRM3|UniProtKB=P49578	Muscarinic acetylcholine receptor M3	IDA			PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00010	B cell activation	P00375	Calmodulin	BRAFL|Gene=BRAFLDRAFT_124869|UniProtKB=C3ZEW0	Putative uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF263	SUBFAMILY NOT NAMED
P00049	Parkinson disease	P01208	Hsp70	THAPS|Gene=Thaps27656|UniProtKB=B8BWB9	Heat shock protein/chaperone	ISS	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P02746	Heme biosynthesis	P02973	Uroporphyrinogen methyltransferase	SCHPO|PomBase=SPCC1739.06c|UniProtKB=O74468	Probable uroporphyrinogen-III C-methyltransferase	ISS			PTHR21091:SF96	UROPORPHYRINOGEN-III C-METHYLTRANSFERASE
P00048	PI3 kinase pathway	P01185	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00046	Oxidative stress response	P01129	JNK1/2	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00053	T cell activation	P01295	vav	MOUSE|MGI=MGI=98923|UniProtKB=P27870	Proto-oncogene vav	IDA	10661401	PubMed	PTHR22826:SF112	PROTO-ONCOGENE VAV
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MOUSE|MGI=MGI=87902|UniProtKB=P68134	Actin, alpha skeletal muscle	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	CHICK|Ensembl=ENSGALG00000001312|UniProtKB=F1NYA3	Uncharacterized protein	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04398	p53 pathway feedback loops 2	P04661	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g210933|UniProtKB=A7SEA7	Predicted protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MOUSE|MGI=MGI=1341902|UniProtKB=Q9WUT7	C-C chemokine receptor type 9	IDA	11884450	PubMed	PTHR10489:SF664	C-C CHEMOKINE RECEPTOR TYPE 9
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00049	Parkinson disease	P01211	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MOUSE|MGI=MGI=1933206|UniProtKB=A2AIR5	Protein Grin3a	ISS	11554549	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00049	Parkinson disease	P01211	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00908	p130CAS	RAT|RGD=2406|UniProtKB=Q63767	Breast cancer anti-estrogen resistance protein 1	ISS	8649368	PubMed	PTHR10654:SF15	BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 1
P00005	Angiogenesis	P00245	Rac	HUMAN|HGNC=31682|UniProtKB=P85299	Proline-rich protein 5	ISS			PTHR32428:SF4	PROLINE-RICH PROTEIN 5
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DROME|FlyBase=FBgn0000489|UniProtKB=P16912	Protein kinase DC2	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04393	Ras Pathway	P04572	JNK	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	15621031	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00044	Nicotinic acetylcholine receptor signaling pathway	P01095	beta	CAEBR|Gene=CBG10871|UniProtKB=A8XC64	Protein CBR-ACR-2	ISS	22213672	PubMed	PTHR18945:SF744	ACETYLCHOLINE RECEPTOR SUBUNIT BETA-TYPE ACR-2
P00034	Integrin signalling pathway	P00943	Talin	PANTR|Ensembl=ENSPTRG00000020917|UniProtKB=H2RC35	Uncharacterized protein	ISS	14702644	PubMed	PTHR19981:SF7	MESODERM DEVELOPMENT CANDIDATE 1-RELATED
P00019	Endothelin signaling pathway	P00566	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS	12874273	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00006	Apoptosis signaling pathway	P00260	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	ORNAN|Ensembl=ENSOANG00000009275|UniProtKB=F7EJA3	Uncharacterized protein	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00012	Cadherin signaling pathway	P00477	GSK3beta	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02743	Formyltetrahydroformate biosynthesis	P02954	Thymidylate synthase	CANAL|CGD=CAL0000189182|UniProtKB=P12461	Thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	SCHPO|PomBase=SPAC6G9.11|UniProtKB=Q92356	Synaptobrevin homolog 1	ISS			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00034	Integrin signalling pathway	P00916	Ras	DANRE|ZFIN=ZDB-GENE-040808-67|UniProtKB=Q6AZA4	K-ras	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00047	PDGF signaling pathway	P01168	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	1171954	gi	PTHR10048:SF14	PI-3 KINASE
P00057	Wnt signaling pathway	P01428	Frizzled	BOVIN|Ensembl=ENSBTAG00000035084|UniProtKB=F1MLG5	Uncharacterized protein	ISS	12549854	PubMed	PTHR11309:SF22	FRIZZLED-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	BACTN|EnsemblGenome=BT_1973|UniProtKB=Q8A6B2	Glutamate dehydrogenase	ISS			PTHR43571:SF1	NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED
P00005	Angiogenesis	P00234	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	8235613	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	STRPU|EnsemblGenome=SPU_007013|UniProtKB=Q964G0	Cyclin D	IEP	22048059	PubMed	PTHR10177:SF246	CYCLIN D, ISOFORM D
P00046	Oxidative stress response	P01129	JNK1/2	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00029	Huntington disease	P00776	c-Jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00019	Endothelin signaling pathway	P00577	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00046	Oxidative stress response	P01132	c-jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04397	p53 pathway by glucose deprivation	P04641	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01311	Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	IDA	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00057	Wnt signaling pathway	P01444	Wnt	DANRE|ZFIN=ZDB-GENE-081006-1|UniProtKB=F1Q9W3	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF73	PROTEIN WNT-7B
P02746	Heme biosynthesis	P02983	Hydroxymethylbilane synthase	BOVIN|Ensembl=ENSBTAG00000005364|UniProtKB=Q2KIN5	Porphobilinogen deaminase	ISS			PTHR11557:SF0	PORPHOBILINOGEN DEAMINASE
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	RAT|RGD=2846|UniProtKB=P28564	5-hydroxytryptamine receptor 1B	ISS	11454663	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	HALSA|EnsemblGenome=VNG_0484G|UniProtKB=Q9HRY8	Acetyl-CoA synthetase	ISS			PTHR24095:SF14	ACETYL-COENZYME A SYNTHETASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00008	Axon guidance mediated by Slit/Robo	P00342	Slit	PANTR|Ensembl=ENSPTRG00000017510|UniProtKB=H2QRZ2	Uncharacterized protein	ISS			PTHR24373:SF15	SLIT HOMOLOG 3 PROTEIN
P00018	EGF receptor signaling pathway	P00565	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	90172230	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02738	De novo purine biosynthesis	P02894	IMP cyclohydrolase	PSEAE|EnsemblGenome=PA4854|UniProtKB=Q9HUV9	Bifunctional purine biosynthesis protein PurH	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P02727	Androgen/estrogene/progesterone biosynthesis	P02829	Cholesterol acyltransferase	RAT|RGD=621641|UniProtKB=O70536	Sterol O-acyltransferase 1	IDA	9555010	PubMed	PTHR10408:SF6	STEROL O-ACYLTRANSFERASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	HUMAN|HGNC=15916|UniProtKB=Q9P286	Serine/threonine-protein kinase PAK 7	ISS			PTHR24361:SF183	SERINE/THREONINE-PROTEIN KINASE PAK 7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	RAT|RGD=620458|UniProtKB=O55145	Fractalkine	ISS			PTHR12015:SF92	FRACTALKINE
P00020	FAS signaling pathway	P00615	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00019	Endothelin signaling pathway	P00586	Gq	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	14765990	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00753	Gbeta	YEAST|SGD=S000005738|UniProtKB=P18851	Guanine nucleotide-binding protein subunit beta	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00005	Angiogenesis	P00226	Delta/Serrate	HUMAN|HGNC=6188|UniProtKB=P78504	Protein jagged-1	IDA	12826675	PubMed	PTHR44097:SF3	PROTEIN JAGGED-1
P00034	Integrin signalling pathway	P00941	Integrin alpha	CANLF|Ensembl=ENSCAFG00000013006|UniProtKB=E2RL88	Uncharacterized protein	ISS	3487386	PubMed	PTHR23220:SF9	INTEGRIN ALPHA-6
P00007	Axon guidance mediated by semaphorins	P00330	CRAM	MACMU|Ensembl=ENSMMUG00000019731|UniProtKB=F7B606	Uncharacterized protein	ISS	11034345	PubMed	PTHR11647:SF58	DIHYDROPYRIMIDINASE-RELATED PROTEIN 5
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	RAT|RGD=2077|UniProtKB=P29410	Adenylate kinase 2, mitochondrial	ISS			PTHR23359:SF117	ADENYLATE KINASE 2, MITOCHONDRIAL
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04393	Ras Pathway	P04558	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00029	Huntington disease	P00807	Actin	PHYPA|Gene=PHYPADRAFT_198730|UniProtKB=Q6TYS2	Actin 1	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00034	Integrin signalling pathway	P00916	Ras	DICPU|Gene=DICPUDRAFT_47179|UniProtKB=F0ZI47	Putative uncharacterized protein rasB	ISS	93205383	PubMed	PTHR24070:SF206	RAS-LIKE PROTEIN RASB
P00047	PDGF signaling pathway	P01167	Ets	RAT|RGD=620697|UniProtKB=G3V9V2	E74-like factor 1, isoform CRA_b	ISS	15298723	PubMed	PTHR11849:SF156	ETS-RELATED TRANSCRIPTION FACTOR ELF-1
P06959	CCKR signaling map	P07203	SP1	HUMAN|HGNC=11205|UniProtKB=P08047	Transcription factor Sp1	RCA	17889508	PubMed	PTHR23235:SF16	TRANSCRIPTION FACTOR SP1
P00019	Endothelin signaling pathway	P00586	Gq	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00021	FGF signaling pathway	P00644	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	MONDO|Ensembl=ENSMODG00000007323|UniProtKB=F7EFD0	Uncharacterized protein	ISS	1904317	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P05917	Opioid proopiomelanocortin pathway	P06009	K+ channel	HUMAN|HGNC=6278|UniProtKB=O14649	Potassium channel subfamily K member 3	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02776	Serine glycine biosynthesis	P03157	Phosphoserine aminotransferase	CAEEL|WormBase=WBGene00009177|UniProtKB=P91856	Probable phosphoserine aminotransferase	ISS			PTHR43247:SF1	PHOSPHOSERINE AMINOTRANSFERASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	14744428	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04393	Ras Pathway	P04569	Cdc42	YEAST|SGD=S000004219|UniProtKB=P19073	Cell division control protein 42	IDA	4757952	gi	PTHR24072:SF192	CDC42 HOMOLOG
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00057	Wnt signaling pathway	P01443	Phospholipase C	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00036	Interleukin signaling pathway	P00965	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	RAT|RGD=2735|UniProtKB=Q63273	Glutamate receptor ionotropic, kainate 5	ISS	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IDA	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P02721	ATP synthesis	P02792	FMN FeS	MYCTU|EnsemblGenome=Rv0694|UniProtKB=P9WND7	Putative mycofactocin system heme/flavin oxidoreductase MftD	ISS	12218036	PubMed	PTHR10578:SF84	HYDROXYACID OXIDASE
P00006	Apoptosis signaling pathway	P00310	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IC	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	P01466	Diversin	RAT|RGD=1583731|UniProtKB=B5DEH9	Ankrd6 protein	ISS	12183362	PubMed	PTHR24203:SF7	ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 6
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	DANRE|ZFIN=ZDB-GENE-040426-2879|UniProtKB=Q6IQJ2	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	MOUSE|MGI=MGI=107471|UniProtKB=P31695	Neurogenic locus notch homolog protein 4	IDA	10206645	PubMed	PTHR43959:SF6	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MOUSE|MGI=MGI=1933206|UniProtKB=A2AIR5	Protein Grin3a	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02784	Tyrosine biosynthesis	P03213	Aromatic amino acid aminotransferase	HUMAN|HGNC=11573|UniProtKB=P17735	Tyrosine aminotransferase	ISS			PTHR11751:SF368	TYROSINE AMINOTRANSFERASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IDA	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	DROME|FlyBase=FBgn0261854|UniProtKB=A1Z9X0	Atypical protein kinase C	IC	3045562	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	STRCO|Gene=CAB71240|UniProtKB=Q9L239	Aldehyde dehydrogenase	IC			PTHR11699:SF202	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000014576|UniProtKB=H2QLZ9	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00855	PLA2	DANRE|ZFIN=ZDB-GENE-990415-45|UniProtKB=P50392	Cytosolic phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00018	EGF receptor signaling pathway	P00556	PLCgamma	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00049	Parkinson disease	P01236	Casein kinase II	MOUSE|MGI=MGI=88548|UniProtKB=P67871	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CAEEL|WormBase=WBGene00006797|UniProtKB=Q9N587	Acetylcholine receptor subunit alpha-type unc-63	IC	85270494	PubMed	PTHR18945:SF592	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-LIKE 1
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	HUMAN|HGNC=24723|UniProtKB=Q9H6R3	Acyl-CoA synthetase short-chain family member 3, mitochondrial	ISS			PTHR43347:SF3	ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL
P00046	Oxidative stress response	P01131	MKP5	BOVIN|Ensembl=ENSBTAG00000016413|UniProtKB=Q17QJ3	Dual specificity protein phosphatase 26	ISS			PTHR10159:SF112	DUAL SPECIFICITY PROTEIN PHOSPHATASE 26
P00036	Interleukin signaling pathway	P00994	FKHRL1	PANTR|Ensembl=ENSPTRG00000018476|UniProtKB=H2R710	Forkhead box O3	ISS	12048180	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00021	FGF signaling pathway	P00642	MEK1-2	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P06959	CCKR signaling map	P07108	Caspase-3	HUMAN|HGNC=1504|UniProtKB=P42574	Caspase-3	RCA	17936584	PubMed	PTHR10454:SF198	CASPASE-3
P00021	FGF signaling pathway	P00648	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	IC	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00013	Cell cycle	P00480	Proteasome	PANTR|Ensembl=ENSPTRG00000008990|UniProtKB=H2QCM9	Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 11	ISS	97227943	PubMed	PTHR10678:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11
P00047	PDGF signaling pathway	P01153	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00047	PDGF signaling pathway	P01152	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	88318957	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	STRPU|EnsemblGenome=SPU_013273|UniProtKB=W4YBZ7	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00060	Ubiquitin proteasome pathway	P01491	E2	MOUSE|MGI=MGI=1917870|UniProtKB=Q9D2M8	Ubiquitin-conjugating enzyme E2 variant 2	ISS			PTHR43915:SF3	UBIQUITIN-CONJUGATING ENZYME E2 VARIANT 2
P00019	Endothelin signaling pathway	P00570	PKA	BOVIN|Ensembl=ENSBTAG00000008621|UniProtKB=P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P02730	Asparagine and aspartate biosynthesis	P02854	Aspartate aminotransferase	SULSO|EnsemblGenome=SSO0897|UniProtKB=P14909	Aspartate aminotransferase	ISS			PTHR11751:SF306	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00912	Arp2/3	MONDO|Ensembl=ENSMODG00000019755|UniProtKB=F6WN64	Actin-related protein 2/3 complex subunit 5	ISS	12932731	PubMed	PTHR12644:SF2	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5-LIKE PROTEIN
P00023	General transcription regulation	P00658	TBP-associated factors	MONDO|Ensembl=ENSMODG00000012785|UniProtKB=F6S0M5	Uncharacterized protein	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	MOUSE|MGI=MGI=88399|UniProtKB=P32211	Muscarinic acetylcholine receptor M4	ISS	12181435	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00561	STAT	CANLF|Ensembl=ENSCAFG00000015509|UniProtKB=F1PNW8	Signal transducer and activator of transcription	ISS	20119183	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00906	Rap1	CANLF|Ensembl=ENSCAFG00000031424|UniProtKB=J9P6K0	Uncharacterized protein	ISS	8576107	PubMed	PTHR24070:SF221	RAS-RELATED PROTEIN RAP-2A
P00019	Endothelin signaling pathway	P00590	IP3 R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00034	Integrin signalling pathway	P00951	Jnk	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00056	VEGF signaling pathway	P01414	PLC-gamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00049	Parkinson disease	P01235	Fyn kinase	DANRE|ZFIN=ZDB-GENE-030903-5|UniProtKB=Q6EWH2	Tyrosine-protein kinase fyna	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04398	p53 pathway feedback loops 2	P04669	ATM	DROME|FlyBase=FBgn0004367|UniProtKB=Q9VXG8	Serine/threonine-protein kinase ATR	ISS			PTHR11139:SF69	SERINE/THREONINE-PROTEIN KINASE ATR
P00019	Endothelin signaling pathway	P00583	cPLA2	ORNAN|Ensembl=ENSOANG00000001027|UniProtKB=F6QDY0	Phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	TAKRU|Ensembl=ENSTRUG00000004787|UniProtKB=P53480	Actin, alpha cardiac	IDA	10974003	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	MACMU|Ensembl=ENSMMUG00000002658|UniProtKB=F7CB14	Uncharacterized protein	ISS	2039532	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	91056091	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	RAT|RGD=2740|UniProtKB=Q62645	Glutamate receptor ionotropic, NMDA 2D	IC	11554549	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00005	Angiogenesis	P00223	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00740	RhoA	XENTR|Xenbase=XB-GENE-941426|UniProtKB=Q28HZ4	Novel Rho protein	ISS	12039949	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00038	JAK/STAT signaling pathway	P01027	STAT	PANTR|Ensembl=ENSPTRG00000009199|UniProtKB=H2QD19	Signal transducer and activator of transcription	ISS	95236292	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00052	TGF-beta signaling pathway	P01284	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00629	PP2A	RAT|RGD=3381|UniProtKB=P62716	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	88248000	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01419	Ets	ORNAN|Ensembl=ENSOANG00000012104|UniProtKB=F7FH70	Uncharacterized protein	ISS	3060801	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05939	GRK6	HUMAN|HGNC=4545|UniProtKB=P43250	G protein-coupled receptor kinase 6	RCA	12032308	PubMed	PTHR24355:SF15	G PROTEIN-COUPLED RECEPTOR KINASE 6
P00005	Angiogenesis	P00227	PLA2	MACMU|Ensembl=ENSMMUG00000021423|UniProtKB=F7EEZ1	Phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00018	EGF receptor signaling pathway	P00552	Ras	DANRE|ZFIN=ZDB-GENE-040808-67|UniProtKB=Q6AZA4	K-ras	ISS	20362513	PubMed	PTHR24070:SF186	GTPASE KRAS
P00034	Integrin signalling pathway	P00922	Collagen	PANTR|Ensembl=ENSPTRG00000014014|UniProtKB=H2QL58	Uncharacterized protein	ISS	10778855	PubMed	PTHR44172:SF1	COLLAGEN ALPHA-2 VI  CHAIN
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=7572|UniProtKB=Q9UKX2	Myosin-2	IC	89264452	PubMed	PTHR13140:SF385	MYOSIN-2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	TAS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEEL|WormBase=WBGene00018620|UniProtKB=O44588	Uncharacterized protein	ISS	2837282	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P00053	T cell activation	P01294	NFAT	MACMU|Ensembl=ENSMMUG00000012657|UniProtKB=F7E7J1	Uncharacterized protein	ISS	9133421	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	IDA	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00050	Plasminogen activating cascade	P01253	Fibrin	MACMU|Ensembl=ENSMMUG00000021302|UniProtKB=F6UZ87	Uncharacterized protein	ISS	223002	gi	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	CANLF|Ensembl=ENSCAFG00000010787|UniProtKB=E2R3W6	Uncharacterized protein	ISS	2039532	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00004	Alzheimer disease-presenilin pathway	P00118	E-cadherin	PANTR|Ensembl=ENSPTRG00000008269|UniProtKB=H2QBE4	Cadherin 3, type 1, P-cadherin (Placental)	ISS	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00005	Angiogenesis	P00233	CSL	DANRE|ZFIN=ZDB-GENE-031117-1|UniProtKB=A4FTT3	Rbpja protein	ISS	9043084	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	10934033	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	DAPPU|EnsemblGenome=DAPPUDRAFT_319998|UniProtKB=E9GNI4	Putative uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00054	Toll receptor signaling pathway	P01346	TLR	DROME|FlyBase=FBgn0262473|UniProtKB=P08953	Protein toll	ISS	12872120	PubMed	PTHR45263:SF1	PROTEIN TOLL
P00034	Integrin signalling pathway	P00922	Collagen	MACMU|Ensembl=ENSMMUG00000021286|UniProtKB=F6V7P3	Collagen alpha-1(III) chain preproprotein	ISS	10778855	PubMed	PTHR24023:SF604	COLLAGEN ALPHA-1 III  CHAIN
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PANTR|Ensembl=ENSPTRG00000018890|UniProtKB=Q5R1X3	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00020	FAS signaling pathway	P00615	JNK	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	TAS	12040174	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00006	Apoptosis signaling pathway	P00260	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04609	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00057	Wnt signaling pathway	P01451	Galpha	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IDA	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05730	Endogenous cannabinoid signaling	P05751	Galpha	TAKRU|Ensembl=ENSTRUG00000017975|UniProtKB=H2VA26	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	12846562	PubMed	PTHR10202:SF13	PRESENILIN-2
P00036	Interleukin signaling pathway	P00965	ERK	CANLF|Ensembl=ENSCAFG00000015640|UniProtKB=E2QVF3	Uncharacterized protein	ISS	gi:31560797	gi	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P05916	Opioid prodynorphin pathway	P06002	G-protein	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P02763	Peptidoglycan biosynthesis	P03083	UDP-N-acetylmuramoylalanine-D-glutamate ligase	BACTN|EnsemblGenome=BT_3450|UniProtKB=Q8A256	UDP-N-acetylmuramoylalanine--D-glutamate ligase	ISS			PTHR43692:SF1	UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00852	PYK2	CANLF|Ensembl=ENSCAFG00000008670|UniProtKB=E2QTG4	Uncharacterized protein	ISS	12640026	PubMed	PTHR24418:SF94	PROTEIN-TYROSINE KINASE 2-BETA
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00054	Toll receptor signaling pathway	P01358	ERK1	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00057	Wnt signaling pathway	P01440	Cadherin	XENTR|Xenbase=XB-GENE-482277|UniProtKB=F6QAX3	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF267	CADHERIN-3
P05913	Enkephalin release	P05972	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	RAT|RGD=70973|UniProtKB=P27732	Voltage-dependent L-type calcium channel subunit alpha-1D	IC	9199552	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P02746	Heme biosynthesis	P02976	Protoporphyrinogen oxidase	RAT|RGD=1310543|UniProtKB=D3ZVN7	Orexin	ISS			PTHR42923:SF3	PROTOPORPHYRINOGEN OXIDASE
P06587	Nicotine pharmacodynamics pathway	P06604	SLC18A2	HUMAN|HGNC=10935|UniProtKB=Q05940	Synaptic vesicular amine transporter	TAS	11443533	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	YEAST|SGD=S000005854|UniProtKB=P33328	Synaptobrevin homolog 2	IC			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P00046	Oxidative stress response	P01135	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00007	Axon guidance mediated by semaphorins	P00339	CRMP	DROME|FlyBase=FBgn0023023|UniProtKB=Q8IPQ2	Collapsin response mediator protein	ISS			PTHR11647:SF1	COLLAPSIN RESPONSE MEDIATOR PROTEIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00097	APPalpha	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00047	PDGF signaling pathway	P01167	Ets	RAT|RGD=1310585|UniProtKB=Q5XIT5	E74-like factor 2	ISS	15298723	PubMed	PTHR11849:SF10	ETS-RELATED TRANSCRIPTION FACTOR ELF-2
P00054	Toll receptor signaling pathway	P01375	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00036	Interleukin signaling pathway	P00968	Ikk	CANLF|Ensembl=ENSCAFG00000009588|UniProtKB=E2RNA9	Uncharacterized protein	ISS	9346484	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P04393	Ras Pathway	P04558	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	12810719	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00029	Huntington disease	P00810	GAPDH	MYCTU|EnsemblGenome=Rv1436|UniProtKB=P9WN83	Glyceraldehyde-3-phosphate dehydrogenase	ISS			PTHR43148:SF2	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE C-RELATED
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MOUSE|MGI=MGI=95817|UniProtKB=Q8BMF5	Glutamate receptor ionotropic, kainate 4	ISS	11319238	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00037	Ionotropic glutamate receptor pathway	P01004	KA1	XENTR|Xenbase=XB-GENE-957124|UniProtKB=F7BDN8	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00010	B cell activation	P00373	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01322	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	IC	10974003	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MONDO|Ensembl=ENSMODG00000014069|UniProtKB=F6R543	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00060	Ubiquitin proteasome pathway	P01491	E2	DANRE|ZFIN=ZDB-GENE-030131-4195|UniProtKB=Q803M4	Uncharacterized protein	ISS			PTHR43898:SF4	UBIQUITIN-CONJUGATING ENZYME E2 A
P00005	Angiogenesis	P00193	SOS-1	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	RAT|RGD=1308614|UniProtKB=Q64057	Alpha-aminoadipic semialdehyde dehydrogenase	ISS			PTHR43521:SF1	ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE
P00049	Parkinson disease	P01227	20S proteasome	SCHPO|PomBase=SPBC106.16|UniProtKB=Q10329	Probable proteasome subunit alpha type-4	TAS	12859888	PubMed	PTHR11599:SF15	PROTEASOME SUBUNIT ALPHA TYPE
P00036	Interleukin signaling pathway	P00976	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04397	p53 pathway by glucose deprivation	P04645	TSC1	MOUSE|MGI=MGI=1929183|UniProtKB=Q9EP53	Hamartin	ISS	12167664	PubMed	PTHR15154:SF2	HAMARTIN
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00011	Blood coagulation	P00431	tPA	MACMU|Ensembl=ENSMMUG00000014432|UniProtKB=F7BHV7	Tissue-type plasminogen activator	ISS	4505861	gi	PTHR44617:SF1	TISSUE-TYPE PLASMINOGEN ACTIVATOR
P00004	Alzheimer disease-presenilin pathway	P00111	C99	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00017	DNA replication	P00536	DNA Topisomerase	MOUSE|MGI=MGI=98788|UniProtKB=Q04750	DNA topoisomerase 1	ISS			PTHR10290:SF5	DNA TOPOISOMERASE 1
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	ANOGA|EnsemblGenome=AGAP001478|UniProtKB=Q7PXM3	AGAP001478-PA	IC	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00047	PDGF signaling pathway	P01162	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00057	Wnt signaling pathway	P01452	NFAT	MACMU|Ensembl=ENSMMUG00000012657|UniProtKB=F7E7J1	Uncharacterized protein	ISS	12787506	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00010	B cell activation	P00401	jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P05734	Synaptic vesicle trafficking	P05774	NSF	CHICK|Ensembl=ENSGALG00000001055|UniProtKB=E1BQU4	Uncharacterized protein	ISS	11348590	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	MONDO|Ensembl=ENSMODG00000004411|UniProtKB=F6SV50	Receptor protein serine/threonine kinase	ISS	10683140	PubMed	PTHR23255:SF58	ACTIVIN RECEPTOR TYPE-1C
P00048	PI3 kinase pathway	P01176	JAK	BOVIN|Ensembl=ENSBTAG00000012047|UniProtKB=E1BCP6	Tyrosine-protein kinase	ISS	14525967	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	TAKRU|Ensembl=ENSTRUG00000001732|UniProtKB=H2RUY9	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P06212	DPP-SCW signaling pathway	P06259	SCW	DROME|FlyBase=FBgn0005590|UniProtKB=P54631	Protein screw	IEA	http://flybase.org/reports/FBgn0005590.html	Website	PTHR11848:SF54	PROTEIN 60A-RELATED
P00023	General transcription regulation	P00658	TBP-associated factors	MACMU|Ensembl=ENSMMUG00000008569|UniProtKB=F6UPU0	Uncharacterized protein	ISS	20355009	PubMed	PTHR15319:SF1	TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT C
P00053	T cell activation	P01300	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00251	cPLA2	ORNAN|Ensembl=ENSOANG00000001027|UniProtKB=F6QDY0	Phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00005	Angiogenesis	P00217	STAT3	CHICK|Ensembl=ENSGALG00000003267|UniProtKB=Q6DV79	Signal transducer and activator of transcription 3	ISS	10642787	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P05916	Opioid prodynorphin pathway	P05999	provasopressin	TAKRU|Ensembl=ENSTRUG00000015631|UniProtKB=H2USP0	Uncharacterized protein	ISS			PTHR11681:SF14	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	HUMAN|HGNC=132|UniProtKB=P60709	Actin, cytoplasmic 1	IC	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00021	FGF signaling pathway	P00627	ERK1-2	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00046	Oxidative stress response	P01134	cPLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02912	dUDP kinase	NEUCR|EnsemblGenome=EFNCRG00000003892|UniProtKB=Q9UUY8	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P00056	VEGF signaling pathway	P01414	PLC-gamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00056	VEGF signaling pathway	P01423	p38MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	GIAIC|EnsemblGenome=GL50803_17587|UniProtKB=E2RU94	CTP synthase	ISS			PTHR11550:SF0	CTP SYNTHASE
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	NEUCR|EnsemblGenome=EFNCRG00000002934|UniProtKB=Q8TG13	Casein kinase II subunit alpha	IDA	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00626	Spry	RAT|RGD=1309293|UniProtKB=B5DFH3	Protein Spry1	ISS	12882970	PubMed	PTHR12365:SF10	PROTEIN SPROUTY HOMOLOG 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000025373|UniProtKB=F6ZZG9	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00029	Huntington disease	P00797	p53	BOVIN|Ensembl=ENSBTAG00000015460|UniProtKB=F1MKA9	Uncharacterized protein	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	MOUSE|MGI=MGI=99460|UniProtKB=Q61982	Neurogenic locus notch homolog protein 3	IDA	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	CHICK|Ensembl=ENSGALG00000013785|UniProtKB=E1BS74	Uncharacterized protein	ISS			PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CAEEL|WormBase=WBGene00004037|UniProtKB=Q9XWB7	Phosphoinositide phospholipase C	TAS			PTHR10336:SF9	PHOSPHOINOSITIDE PHOSPHOLIPASE C
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	TAS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	DANRE|ZFIN=ZDB-GENE-020125-5|UniProtKB=A2CG69	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF356	SUBFAMILY NOT NAMED
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P02740	De novo pyrimidine ribonucleotides biosythesis	P02922	Orotate phosphoribosyltransferase	STRCO|EnsemblGenome=CAB42037|UniProtKB=Q9X8R7	Orotate phosphoribosyltransferase	ISS			PTHR19278:SF9	URIDINE 5'-MONOPHOSPHATE SYNTHASE
P00054	Toll receptor signaling pathway	P01369	MKK1	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00006	Apoptosis signaling pathway	P00297	NFkappaB	BOVIN|Ensembl=ENSBTAG00000020270|UniProtKB=F1MKW9	Uncharacterized protein	ISS	12574369	PubMed	PTHR24169:SF9	NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00021	FGF signaling pathway	P00644	p38	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	11991731	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00557	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000004526|UniProtKB=H2Q573	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00048	PI3 kinase pathway	P01192	p110	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00053	T cell activation	P01330	IKK	CANLF|Ensembl=ENSCAFG00000005526|UniProtKB=E2RKR0	Uncharacterized protein	ISS	12529410	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P05731	GABA-B receptor II signaling	P05752	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00029	Huntington disease	P00805	Akt	HUMAN|HGNC=393|UniProtKB=Q9Y243	RAC-gamma serine/threonine-protein kinase	IDA	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	10021384	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00021	FGF signaling pathway	P00643	Raf-1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00547	PP2A	BOVIN|Ensembl=ENSBTAG00000019784|UniProtKB=A4FV68	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	ISS	11007767	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00029	Huntington disease	G01533	Bax	BOVIN|Ensembl=ENSBTAG00000013340|UniProtKB=O02703	Apoptosis regulator BAX	ISS	8358790	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04558	p38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	IDA	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00251	cPLA2	HUMAN|HGNC=9035|UniProtKB=P47712	Cytosolic phospholipase A2	IDA	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04398	p53 pathway feedback loops 2	P04657	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05934	ELK1	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	11050086	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00021	FGF signaling pathway	P00632	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P06000	vasopressin	DANRE|ZFIN=ZDB-GENE-030407-1|UniProtKB=F1QC27	Uncharacterized protein	ISS			PTHR11681:SF14	SUBFAMILY NOT NAMED
P02757	O-antigen biosynthesis	P03048	UDP-galacto-pyranose mutase	DEIRA|EnsemblGenome=DR_A0367|UniProtKB=Q9RYF1	UDP-galactopyranose mutase	ISS			PTHR21197:SF0	UDP-GALACTOPYRANOSE MUTASE
P05917	Opioid proopiomelanocortin pathway	P06010	proopiomelanocortin	MONDO|Ensembl=ENSMODG00000015853|UniProtKB=Q95J84	Proopiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00030	Hypoxia response via HIF activation	P00824	PTEN	XENTR|Xenbase=XB-GENE-491433|UniProtKB=B1H2U0	Pten protein	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00034	Integrin signalling pathway	P00951	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CHICK|Ensembl=ENSGALG00000027629|UniProtKB=Q5ZJ03	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00006	Apoptosis signaling pathway	P00302	ATF	RAT|RGD=1305471|UniProtKB=G3V909	Cyclic AMP-dependent transcription factor ATF-6 alpha	ISS	11390664	PubMed	PTHR22952:SF116	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-6 ALPHA
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	CANLF|Gene=PSEN1|UniProtKB=Q6RH31	Presenilin-1	TAS	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P00015	Circadian clock system	G01501	cry	RAT|RGD=620935|UniProtKB=Q923I8	Cryptochrome-2	IDA	11533252	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	PANTR|Ensembl=ENSPTRG00000010239|UniProtKB=H2QEX1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MACMU|Ensembl=ENSMMUG00000017431|UniProtKB=F7HPP3	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00379	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02756	N-acetylglucosamine metabolism	P03039	Glucosamine-1-phosphate acetyltransferase	FUSNN|EnsemblGenome=FN1991|UniProtKB=Q8RHM3	Bifunctional protein GlmU	ISS			PTHR43584:SF3	BIFUNCTIONAL PROTEIN GLMU
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS	12878610	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00019	Endothelin signaling pathway	P00568	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	ISS	11684013	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MOUSE|MGI=MGI=87905|UniProtKB=P68033	Actin, alpha cardiac muscle 1	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00037	Ionotropic glutamate receptor pathway	P01026	KA	BOVIN|Ensembl=ENSBTAG00000011723|UniProtKB=E1BKL6	Uncharacterized protein	ISS	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00841	AC	MACMU|Ensembl=ENSMMUG00000018742|UniProtKB=F6Y327	Adenylate cyclase type 2	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02772	Pyruvate metabolism	P03133	Pyruvate Dehydrogenase	HUMAN|HGNC=8806|UniProtKB=P08559	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial	RCA			PTHR11516:SF52	PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA, SOMATIC FORM, MITOCHONDRIAL
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	MACMU|Ensembl=ENSMMUG00000022347|UniProtKB=F6ZCH5	Uncharacterized protein	ISS	1648176	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00056	VEGF signaling pathway	P01414	PLC-gamma	MOUSE|MGI=MGI=97615|UniProtKB=Q62077	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00046	Oxidative stress response	P01129	JNK1/2	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00009	Axon guidance mediated by netrin	P00363	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01319	PAK	HUMAN|HGNC=8590|UniProtKB=Q13153	Serine/threonine-protein kinase PAK 1	IDA	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02775	Salvage pyrimidine ribonucleotides	P03150	Uridine kinase	DROME|FlyBase=FBgn0022029|UniProtKB=Q8MQK4	Uridine kinase	ISS			PTHR10285:SF123	URIDINE KINASE
P00021	FGF signaling pathway	P00640	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00045	Notch signaling pathway	P01107	Fringe	HUMAN|HGNC=7038|UniProtKB=O00587	Beta-1,3-N-acetylglucosaminyltransferase manic fringe	ISS			PTHR10811:SF6	BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE MANIC FRINGE
P00048	PI3 kinase pathway	P01192	p110	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MONDO|Ensembl=ENSMODG00000023940|UniProtKB=F6RFW8	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00059	p53 pathway	G04702	p53	MOUSE|MGI=MGI=1330810|UniProtKB=O88898	Tumor protein 63	TAS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CHICK|Ensembl=ENSGALG00000001381|UniProtKB=P53478	Actin, cytoplasmic type 5	ISS	10974003	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00059	p53 pathway	P04609	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04393	Ras Pathway	P04546	GSK3	MACMU|Ensembl=ENSMMUG00000014597|UniProtKB=F6VAQ6	Glycogen synthase kinase-3 alpha	ISS	14698990	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00018	EGF receptor signaling pathway	P00554	Shc	PANTR|Ensembl=ENSPTRG00000001397|UniProtKB=H2R8L2	SHC (Src homology 2 domain containing) transforming protein 1	ISS	10982827	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	ISS	http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P02753	Methionine biosynthesis	P03024	Homocysteine transmethylase	ARATH|TAIR=AT3G63250|UniProtKB=Q9M1W4	Homocysteine S-methyltransferase 2	ISS			PTHR21091:SF123	FI01821P
P00037	Ionotropic glutamate receptor pathway	P01026	KA	RAT|RGD=2733|UniProtKB=P42260	Glutamate receptor ionotropic, kainate 2	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00025	Hedgehog signaling pathway	P00682	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00805	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IDA	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04567	PI3K	CANLF|Ensembl=ENSCAFG00000017725|UniProtKB=E2RIF9	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	CAEEL|WormBase=WBGene00000053|UniProtKB=Q22224	AcetylCholine Receptor	IC			PTHR18945:SF441	ACETYLCHOLINE RECEPTOR
P00057	Wnt signaling pathway	P01454	betaTrCP	MOUSE|MGI=MGI=1338871|UniProtKB=Q3ULA2	F-box/WD repeat-containing protein 1A	IDA	10074433	PubMed	PTHR44038:SF2	F-BOX/WD REPEAT-CONTAINING PROTEIN 1A
P00005	Angiogenesis	P00183	Shc	HUMAN|HGNC=10840|UniProtKB=P29353	SHC-transforming protein 1	IDA	95096035	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00029	Huntington disease	P00775	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	10891487	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P05916	Opioid prodynorphin pathway	P06002	G-protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IC	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00204	PLD	HUMAN|HGNC=9068|UniProtKB=O14939	Phospholipase D2	ISS	12615079	PubMed	PTHR18896:SF76	PHOSPHOLIPASE D2
P00029	Huntington disease	P00796	Kainate receptor	HUMAN|HGNC=4581|UniProtKB=Q13003	Glutamate receptor ionotropic, kainate 3	IDA	95236038	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01332	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	IDA	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00056	VEGF signaling pathway	P01425	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00029	Huntington disease	P00796	Kainate receptor	PANTR|Ensembl=ENSPTRG00000018449|UniProtKB=H2QTG5	Uncharacterized protein	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05941	GRK3	MONDO|Ensembl=ENSMODG00000010516|UniProtKB=F7DR73	Protein-serine/threonine kinase	ISS	8288567	PubMed	PTHR24355:SF17	BETA-ADRENERGIC RECEPTOR KINASE 2
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=1306541|UniProtKB=D3ZVF3	Phosphoinositide-3-kinase, class 2, beta polypeptide (Predicted)	ISS	7937853	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P00047	PDGF signaling pathway	P01154	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MACMU|Ensembl=ENSMMUG00000014807|UniProtKB=F6W548	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	12860966	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=4595|UniProtKB=Q14832	Metabotropic glutamate receptor 3	IDA	9407094	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00057	Wnt signaling pathway	P01443	Phospholipase C	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IDA	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00049	Parkinson disease	P01236	Casein kinase II	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g245041|UniProtKB=A7SG27	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00024	Glycolysis	P00678	Enolase	RAT|RGD=2553|UniProtKB=P04764	Alpha-enolase	ISS	99439677	PubMed	PTHR11902:SF12	ALPHA-ENOLASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	BOVIN|Ensembl=ENSBTAG00000006495|UniProtKB=P11017	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	94280860	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00036	Interleukin signaling pathway	P00973	PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00260	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	PANTR|Ensembl=ENSPTRG00000019208|UniProtKB=H2QUM1	Uncharacterized protein	ISS	1370475	PubMed	PTHR44087:SF1	PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, SKELETAL MUSCLE/HEART ISOFORM
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00036	Interleukin signaling pathway	P00965	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IC	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00038	JAK/STAT signaling pathway	P01027	STAT	MONDO|Ensembl=ENSMODG00000014836|UniProtKB=F7D2D3	Signal transducer and activator of transcription	ISS	22320921	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	XENTR|Xenbase=XB-GENE-491618|UniProtKB=Q6P378	Actin, cytoplasmic 2	ISS	11889139	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	HUMAN|HGNC=7775|UniProtKB=O95644	Nuclear factor of activated T-cells, cytoplasmic 1	ISS	9462517	PubMed	PTHR12533:SF5	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 1
P00023	General transcription regulation	P00658	TBP-associated factors	MACMU|Ensembl=ENSMMUG00000030199|UniProtKB=F7HPQ9	Uncharacterized protein	ISS			PTHR13218:SF15	TAF11-LIKE PROTEIN ENSP00000332601-RELATED
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000019846|UniProtKB=F7GUW1	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF99	CADHERIN-9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	XENTR|Xenbase=XB-GENE-6469705|UniProtKB=Q6P8G3	Actin, alpha sarcomeric/skeletal	ISS	11889126	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	TAS	3045562	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IGI	1718748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	91056091	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00006	Apoptosis signaling pathway	P00321	HSP70	BOVIN|Ensembl=ENSBTAG00000013162|UniProtKB=P19120	Heat shock cognate 71 kDa protein	ISS	12150907	PubMed	PTHR19375:SF239	HEAT SHOCK COGNATE 71 KDA PROTEIN
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00034	Integrin signalling pathway	P00907	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IDA	11790551	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000021437|UniProtKB=H2QXZ6	Uncharacterized protein	ISS	11554554	PubMed	PTHR24356:SF175	SERINE/THREONINE-PROTEIN KINASE N3
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00197	Grb14	RAT|RGD=61869|UniProtKB=O88900	Growth factor receptor-bound protein 14	ISS			PTHR11243:SF22	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 14
P00029	Huntington disease	P00811	Arp2/3 complex	ORNAN|Ensembl=ENSOANG00000007724|UniProtKB=F6QTB5	Uncharacterized protein	ISS	12473693	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P00010	B cell activation	P00374	Lyn	HUMAN|HGNC=6735|UniProtKB=P07948	Tyrosine-protein kinase Lyn	IDA	11078745	PubMed	PTHR24418:SF42	TYROSINE-PROTEIN KINASE LYN
P00050	Plasminogen activating cascade	P01246	Plasmin	BOVIN|Gene=PLG|UniProtKB=P06868	Plasminogen	ISS	2507247	gi	PTHR24261:SF5	PLASMINOGEN
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00047	PDGF signaling pathway	P01153	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	7667318	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00057	Wnt signaling pathway	P01443	Phospholipase C	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00030	Hypoxia response via HIF activation	P00823	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	14505573	PubMed	PTHR10048:SF14	PI-3 KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	IDA	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	DICDI|dictyBase=DDB_G0289601|UniProtKB=P54676	Phosphatidylinositol 3-kinase VPS34-like	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00023	General transcription regulation	P00658	TBP-associated factors	PANTR|Ensembl=ENSPTRG00000019474|UniProtKB=H2QV18	Uncharacterized protein	ISS			PTHR10221:SF12	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6
P05918	p38 MAPK pathway	P06015	p38gamma	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	ANOGA|EnsemblGenome=AGAP001394|UniProtKB=F5HMS4	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00591	PLCbeta	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00018	EGF receptor signaling pathway	P00543	ERK1-2	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	BOVIN|Ensembl=ENSBTAG00000005464|UniProtKB=E1B9K3	Uncharacterized protein	ISS	92409599	PubMed	PTHR11920:SF343	ADENYLATE CYCLASE TYPE 6
P00059	p53 pathway	P04633	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00094	BACE-1 pro-domain	PANTR|Ensembl=ENSPTRG00000004324|UniProtKB=H2Q4U8	Beta-site APP-cleaving enzyme 1	ISS	10956649	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P00018	EGF receptor signaling pathway	P00554	Shc	CAEEL|WormBase=WBGene00018788|UniProtKB=Q9TYT3	SHC-transforming protein homolog 1	ISS	600560	OMIM	PTHR10337:SF11	DSHC PROTEIN
P00038	JAK/STAT signaling pathway	P01027	STAT	MONDO|Ensembl=ENSMODG00000014836|UniProtKB=F7D2D3	Signal transducer and activator of transcription	ISS	96210005	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00029	Huntington disease	P00776	c-Jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CANLF|Ensembl=ENSCAFG00000016413|UniProtKB=F1P977	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04393	Ras Pathway	P04573	Elk-1	RAT|RGD=1598663|UniProtKB=A4GTP4	ETS domain-containing protein Elk-1	ISS	11151091	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P00005	Angiogenesis	P00211	GSK3beta	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00054	Toll receptor signaling pathway	P01358	ERK1	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01142	p90RSK	ORNAN|Ensembl=ENSOANG00000002226|UniProtKB=F6TPX7	Ribosomal protein S6 kinase	ISS	11861821	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00011	Blood coagulation	P00416	Prothrombin	RAT|RGD=61996|UniProtKB=P18292	Prothrombin	ISS	12621076	gi	PTHR24254:SF10	PROTHROMBIN
P00034	Integrin signalling pathway	P00914	Filamin	MACMU|Ensembl=ENSMMUG00000013668|UniProtKB=F7GCM2	Uncharacterized protein	ISS	9722563	PubMed	PTHR43998:SF6	FILAMIN-A
P00036	Interleukin signaling pathway	P00982	p27KIP1	RAT|RGD=69062|UniProtKB=O08769	Cyclin dependent kinase inhibitor	ISS	9330642	PubMed	PTHR10265:SF9	CYCLIN-DEPENDENT KINASE INHIBITOR 1B
P04398	p53 pathway feedback loops 2	P04661	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	MOUSE|MGI=MGI=99484|UniProtKB=Q60680	Inhibitor of nuclear factor kappa-B kinase subunit alpha	RCA			PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00021	FGF signaling pathway	P00633	Ras	DICDI|dictyBase=DDB_G0292996|UniProtKB=P03967	Ras-like protein rasD	IDA	85024887	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00021	FGF signaling pathway	P00624	14-3-3	DAPPU|EnsemblGenome=DAPPUDRAFT_307391|UniProtKB=E9H1W5	14-3-3 zeta	ISS	10407019	PubMed	PTHR18860:SF13	14-3-3 PROTEIN ZETA
P00053	T cell activation	P01305	Calmodulin	MACMU|Ensembl=ENSMMUG00000028962|UniProtKB=F7EWG5	Uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF322	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MACMU|Ensembl=ENSMMUG00000002214|UniProtKB=Q28509	Beta-2 adrenergic receptor	IDA	12063255	PubMed	PTHR24248:SF21	BETA-2 ADRENERGIC RECEPTOR
P00049	Parkinson disease	P01219	SAPK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	NAS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	MOUSE|MGI=MGI=1202717|UniProtKB=P49769	Presenilin-1	IDA	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00052	TGF-beta signaling pathway	P01275	P38	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	TAS	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00015	Circadian clock system	P00504	Per	PANTR|Ensembl=ENSPTRG00000008726|UniProtKB=H2QC70	Uncharacterized protein	ISS	12782655	PubMed	PTHR11269:SF8	PERIOD CIRCADIAN PROTEIN HOMOLOG 1
P00036	Interleukin signaling pathway	P00990	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00839	SHIP	PANTR|Ensembl=ENSPTRG00000004031|UniProtKB=H2Q4C6	Inositol polyphosphate phosphatase-like 1	ISS	9824312	PubMed	PTHR11200:SF15	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00729	Goalpha	PANTR|Ensembl=ENSPTRG00000008129|UniProtKB=H2QB45	Uncharacterized protein	ISS	10188796	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	HUMAN|HGNC=4588|UniProtKB=O15399	Glutamate receptor ionotropic, NMDA 2D	ISS	11554549	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MACMU|Ensembl=ENSMMUG00000001353|UniProtKB=F7D6T8	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	HUMAN|HGNC=8743|UniProtKB=P29120	Neuroendocrine convertase 1	IDA			PTHR42884:SF14	NEUROENDOCRINE CONVERTASE 1
P00034	Integrin signalling pathway	P00927	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	10540223	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00047	PDGF signaling pathway	P01160	IP3 receptor	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01069	mAChR1/3	MACMU|Ensembl=ENSMMUG00000021442|UniProtKB=F7EAQ8	Muscarinic acetylcholine receptor	ISS	10069496	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	MONDO|Ensembl=ENSMODG00000004495|UniProtKB=F6VQP7	Uncharacterized protein	ISS	12621039	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IGI	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00843	Raf-1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	RCA	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT2G18170|UniProtKB=Q39027	Mitogen-activated protein kinase 7	ISS	8282107	PubMed	PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TAKRU|Ensembl=ENSTRUG00000005494|UniProtKB=P53483	Actin, alpha anomalous	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00717	Phosphorylase b	HUMAN|HGNC=9726|UniProtKB=P11217	Glycogen phosphorylase, muscle form	IDA	4318782	PubMed	PTHR11468:SF13	GLYCOGEN PHOSPHORYLASE, MUSCLE FORM
P04393	Ras Pathway	P04550	Ral	CANLF|Ensembl=ENSCAFG00000030906|UniProtKB=J9NX28	Uncharacterized protein	ISS	11025226	PubMed	PTHR24070:SF174	RAS-RELATED PROTEIN RAL-A
P00019	Endothelin signaling pathway	P00577	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	12707323	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00034	Integrin signalling pathway	P00932	FAK	MACMU|Ensembl=ENSMMUG00000019159|UniProtKB=F6SS49	Uncharacterized protein	ISS	12640026	PubMed	PTHR24418:SF94	PROTEIN-TYROSINE KINASE 2-BETA
P00029	Huntington disease	P00780	Microtubule	TRIVA|Gene=TVAG_008680|UniProtKB=A2DC16	Beta-tubulin, putative	IDA	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P05913	Enkephalin release	P05974	G-Protein (i)	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	PANTR|Ensembl=ENSPTRG00000003795|UniProtKB=H2Q3X5	Muscarinic acetylcholine receptor	ISS	10069496	PubMed	PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P00037	Ionotropic glutamate receptor pathway	P01018	Glu1	HUMAN|HGNC=4571|UniProtKB=P42261	Glutamate receptor 1	ISS	10331083	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01190	PDK1 ACT	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	IDA	9445477	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	HUMAN|HGNC=9388|UniProtKB=P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	IDA	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04384	Gamma-aminobutyric acid synthesis	P04480	GABA aminotransferase	YEAST|SGD=S000003251|UniProtKB=P17649	4-aminobutyrate aminotransferase	ISS	8133261	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P02766	Phenylethylamine degradation	P03103	Phenylethylamine oxidase	MOUSE|MGI=MGI=3618290|UniProtKB=Q6IMK7	Amine oxidase	ISS			PTHR10638:SF22	AMINE OXIDASE
P00038	JAK/STAT signaling pathway	P01027	STAT	PANTR|Ensembl=ENSPTRG00000009200|UniProtKB=H2QD20	Signal transducer and activator of transcription	ISS	15591053	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00020	FAS signaling pathway	P00606	Caspase10	PANTR|Ensembl=ENSPTRG00000012800|UniProtKB=H2R694	Uncharacterized protein	ISS	8755496	PubMed	PTHR10454:SF26	CASPASE-10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00047	PDGF signaling pathway	P01161	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	3449797	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	NAS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	G04692	R2	BOVIN|Ensembl=ENSBTAG00000008216|UniProtKB=E1BI58	Uncharacterized protein	ISS			PTHR23409:SF20	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00009	Axon guidance mediated by netrin	P00363	PI3K	MOUSE|MGI=MGI=1203729|UniProtKB=Q61194	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	IDA	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=5295|UniProtKB=P28335	5-hydroxytryptamine receptor 2C	IDA			PTHR24247:SF32	5-HYDROXYTRYPTAMINE RECEPTOR 2C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	DANRE|ZFIN=ZDB-GENE-031007-5|UniProtKB=E7EYV0	Uncharacterized protein	TAS	13928778	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01232	CASK	CAEBR|Gene=CBG00133|UniProtKB=A8WMC8	Protein CBR-LIN-2	ISS	11679592	PubMed	PTHR23122:SF7	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	HUMAN|HGNC=4408|UniProtKB=P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	IC			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000001187|UniProtKB=F6R8N9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00047	PDGF signaling pathway	P01154	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P00048	PI3 kinase pathway	P01181	GSK3	MONDO|Ensembl=ENSMODG00000018216|UniProtKB=F6PGQ1	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04393	Ras Pathway	P04553	PAK	MOUSE|MGI=MGI=1339975|UniProtKB=O88643	Serine/threonine-protein kinase PAK 1	IDA	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IDA	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	DROME|FlyBase=FBgn0010341|UniProtKB=P40793	Cdc42 homolog	ISS	12932731	PubMed	PTHR24072:SF192	CDC42 HOMOLOG
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	RAT|RGD=3100|UniProtKB=P50280	Matrilysin	IEP	12356903	PubMed	PTHR10201:SF143	MATRILYSIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	BOVIN|Ensembl=ENSBTAG00000016043|UniProtKB=E1BB14	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	RAT|RGD=628732|UniProtKB=P59215	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P05913	Enkephalin release	P05972	PKA	RAT|RGD=3389|UniProtKB=P27791	cAMP-dependent protein kinase catalytic subunit alpha	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04393	Ras Pathway	P04556	Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	IDA	12068308	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	TAS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00036	Interleukin signaling pathway	P00973	PKB	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01082	AC	RAT|RGD=708450|UniProtKB=Q9Z286	Adenylate cyclase type 10	IC	9874775	PubMed	PTHR16305:SF28	ADENYLATE CYCLASE TYPE 10
P00035	Interferon-gamma signaling pathway	P00956	SOCS	MOUSE|MGI=MGI=103159|UniProtKB=Q62225	Cytokine-inducible SH2-containing protein	ISS	15032587	PubMed	PTHR44649:SF1	CYTOKINE-INDUCIBLE SH2-CONTAINING PROTEIN
P04392	P53 pathway feedback loops 1	G04682	MDM-2	BOVIN|Ensembl=ENSBTAG00000010422|UniProtKB=F1MYE6	Uncharacterized protein	ISS	7477327	PubMed	PTHR13844:SF15	E3 UBIQUITIN-PROTEIN LIGASE MDM2
P00059	p53 pathway	P04635	Sumo-1 ligase	RAT|RGD=1561022|UniProtKB=Q5XIF4	Small ubiquitin-related modifier 3	ISS			PTHR10562:SF50	SMALL UBIQUITIN-RELATED MODIFIER 3
P05916	Opioid prodynorphin pathway	P06001	AC	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	ISS	2491850	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00034	Integrin signalling pathway	P00916	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00021	FGF signaling pathway	P00624	14-3-3	CANLF|Ensembl=ENSCAFG00000000580|UniProtKB=F1PBL1	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	HUMAN|HGNC=12786|UniProtKB=O00755	Protein Wnt-7a	TAS	11266476	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00005	Angiogenesis	P00215	Nck	HUMAN|HGNC=7664|UniProtKB=P16333	Cytoplasmic protein NCK1	IDA	11689432	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P04397	p53 pathway by glucose deprivation	P04646	alpha4	MOUSE|MGI=MGI=1346500|UniProtKB=Q61249	Immunoglobulin-binding protein 1	IDA	9573385	PubMed	PTHR10933:SF11	IMMUNOGLOBULIN-BINDING PROTEIN 1
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05915	Opioid proenkephalin pathway	P05994	G-protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00045	Notch signaling pathway	P01120	NIcs	CANLF|Ensembl=ENSCAFG00000010476|UniProtKB=F1PS94	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	8787761	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00029	Huntington disease	P00807	Actin	YEAST|SGD=S000001855|UniProtKB=P60010	Actin	IDA	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	HUMAN|HGNC=130|UniProtKB=P62736	Actin, aortic smooth muscle	IC	11889126	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=97592|UniProtKB=P05132	cAMP-dependent protein kinase catalytic subunit alpha	IC	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CAEEL|WormBase=WBGene00003774|UniProtKB=G5EGQ9	NMDA class glutamate Receptor	IC	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04395	Vasopressin synthesis	P04597	Signal Peptide	HUMAN|HGNC=8528|UniProtKB=P01178	Oxytocin-neurophysin 1	ISS	9756087	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00005	Angiogenesis	P00238	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P00019	Endothelin signaling pathway	P00577	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	IGI	96320556	PubMed	PTHR10048:SF14	PI-3 KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	DANRE|ZFIN=ZDB-GENE-050320-65|UniProtKB=Q5BJ11	Gnb2 protein	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	ANOGA|EnsemblGenome=AGAP003040|UniProtKB=Q7QDB4	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF110	RIBOSOMAL PROTEIN S6 KINASE II, ISOFORM A
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00036	Interleukin signaling pathway	P00975	RasGAP	ORNAN|Ensembl=ENSOANG00000014753|UniProtKB=F7EPN2	Uncharacterized protein (Fragment)	ISS	15489039	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01168	PI3K	DICDI|dictyBase=DDB_G0283081|UniProtKB=P54674	Phosphatidylinositol 3-kinase 2	ISS	1171954	gi	PTHR10048:SF14	PI-3 KINASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	YEAST|SGD=S000004230|UniProtKB=P22543	Phosphatidylinositol 3-kinase VPS34	ISS	14526383	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05929	Ggamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00029	Huntington disease	P00807	Actin	BOVIN|Ensembl=ENSBTAG00000005714|UniProtKB=Q3ZC07	Actin, alpha cardiac muscle 1	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00021	FGF signaling pathway	P00628	JNK1-3	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00034	Integrin signalling pathway	P00936	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01452	NFAT	HUMAN|HGNC=7778|UniProtKB=Q14934	Nuclear factor of activated T-cells, cytoplasmic 4	IDA	12015605	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00004	Alzheimer disease-presenilin pathway	P00147	TACE	CANLF|Ensembl=ENSCAFG00000003383|UniProtKB=F1PFZ9	Uncharacterized protein	ISS	9774383	PubMed	PTHR11905:SF171	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17
P00023	General transcription regulation	P00670	TBP	ORNAN|Ensembl=ENSOANG00000013097|UniProtKB=F6UVN1	Uncharacterized protein	ISS	10082669	PubMed	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00021	FGF signaling pathway	P00640	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IGI	7937853	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00005	Angiogenesis	P00203	Erk	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00759	PDEalphabeta	MOUSE|MGI=MGI=97525|UniProtKB=P23440	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	ISS	P35913	SPACC	PTHR11347:SF73	ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT BETA
P04393	Ras Pathway	P04558	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IDA	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00034	Integrin signalling pathway	P00916	Ras	CAEEL|WormBase=WBGene00002335|UniProtKB=P22981	Ras protein let-60	IPI	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00005	Angiogenesis	P00205	GAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	227170	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00036	Interleukin signaling pathway	P00970	Interleukin	PANTR|Ensembl=ENSPTRG00000018274|UniProtKB=H2QT65	Uncharacterized protein	ISS			PTHR45214:SF1	INTERLEUKIN-17F
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	2837282	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04398	p53 pathway feedback loops 2	G04711	SIAH-1	PANTR|Ensembl=ENSPTRG00000008094|UniProtKB=H2QB23	E3 ubiquitin-protein ligase	ISS	11389839	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000014976|UniProtKB=H2R892	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF111	METABOTROPIC GLUTAMATE RECEPTOR 2
P00010	B cell activation	P00385	Rac	RAT|RGD=1307568|UniProtKB=Q5U1Y2	Protein Rac2	ISS	10802295	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00045	Notch signaling pathway	P01110	Presenilin	MACMU|Ensembl=ENSMMUG00000010173|UniProtKB=F7AGU8	Presenilin	ISS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MONDO|Ensembl=ENSMODG00000010521|UniProtKB=F7DQK7	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00049	Parkinson disease	P01227	20S proteasome	PANTR|Ensembl=ENSPTRG00000021354|UniProtKB=H2QXV4	Proteasome subunit beta type	ISS	12859888	PubMed	PTHR11599:SF42	PROTEASOME SUBUNIT BETA TYPE-7
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	HUMAN|HGNC=4588|UniProtKB=O15399	Glutamate receptor ionotropic, NMDA 2D	IC	14698601	PubMed	PTHR43958:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00474	Wnt	BRAFL|Gene=BRAFLDRAFT_104698|UniProtKB=C3XYW6	Protein Wnt (Fragment)	IDA	11266476	PubMed	PTHR12027:SF81	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	94280860	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00029	Huntington disease	P00786	ARF	ENTHI|EnsemblGenome=EHI_073470|UniProtKB=C4LXL1	ADP-ribosylation factor 1, putative	IPI	12932731	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00047	PDGF signaling pathway	P01142	p90RSK	BOVIN|Ensembl=ENSBTAG00000014447|UniProtKB=A4IFF4	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF43	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
P00046	Oxidative stress response	P01134	cPLA2	BOVIN|Ensembl=ENSBTAG00000013298|UniProtKB=A4IFJ5	Cytosolic phospholipase A2	ISS	1709551	gi	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00005	Angiogenesis	P00182	p38MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	BOVIN|Gene=DRD2|UniProtKB=P20288	D(2) dopamine receptor	ISS	11861492	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00012	Cadherin signaling pathway	P00475	Frizzled	PANTR|Ensembl=ENSPTRG00000009279|UniProtKB=H2QD74	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF34	FRIZZLED-2
P00034	Integrin signalling pathway	P00951	Jnk	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	IC			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00021	FGF signaling pathway	P00640	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00012	Cadherin signaling pathway	P00470	F-actin	SCHMA|EnsemblGenome=Smp_183710|UniProtKB=G4VLW1	Putative actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00021	FGF signaling pathway	P00645	Rac	ENTHI|EnsemblGenome=EHI_197840|UniProtKB=C4M8K6	Rho family GTPase	ISS	12932731	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00623	FGF	PANTR|Ensembl=ENSPTRG00000022328|UniProtKB=H2QZ66	Fibroblast growth factor	ISS	12496262	PubMed	PTHR11486:SF77	FIBROBLAST GROWTH FACTOR 13
P04393	Ras Pathway	P04570	AKT	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	IDA	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	87137688	PubMed	PTHR24070:SF189	GTPASE NRAS
P05915	Opioid proenkephalin pathway	P05995	proenkephalin	DANRE|ZFIN=ZDB-GENE-030729-3|UniProtKB=F1QTD1	Uncharacterized protein (Fragment)	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01428	Frizzled	BOVIN|Ensembl=ENSBTAG00000040128|UniProtKB=F1MLJ8	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF23	FRIZZLED-4
P00029	Huntington disease	P00790	beta-Tubulin	RAT|RGD=1305887|UniProtKB=Q4QQV0	Protein Tubb6	TAS	12932731	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00018	EGF receptor signaling pathway	P00551	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00807	Actin	ORNAN|Ensembl=ENSOANG00000007581|UniProtKB=F6QWB7	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF243	ACTIN, CYTOPLASMIC TYPE 5
P00034	Integrin signalling pathway	P00936	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IPI	14526383	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00030	Hypoxia response via HIF activation	P00823	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01411	Ras	CHICK|Ensembl=ENSGALG00000006885|UniProtKB=P08642	GTPase HRas	ISS	87226391	PubMed	PTHR24070:SF385	GTPASE HRAS
P00057	Wnt signaling pathway	P01438	PP2A	RAT|RGD=1585097|UniProtKB=A0A0G2JZD1	Protein Ppp2r5c	ISS	10092233	PubMed	PTHR10257:SF19	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM
P00018	EGF receptor signaling pathway	P00561	STAT	MOUSE|MGI=MGI=103038|UniProtKB=P42227	Signal transducer and activator of transcription 3	ISS	10207096	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P05913	Enkephalin release	P05977	G-Protein (s)	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04398	p53 pathway feedback loops 2	P04665	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P02758	Ornithine degradation	P03053	Ornithine decarboxylase	PHANO|EnsemblGenome=SNOG_03643|UniProtKB=F5HBY2	Uncharacterized protein	ISS			PTHR11482:SF6	ORNITHINE DECARBOXYLASE 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	IDA	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04386	Histamine H2 receptor mediated signaling pathway	P04490	G-Protein	PANTR|Ensembl=ENSPTRG00000007118|UniProtKB=H2QXP3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00240	FRS-2	BOVIN|Ensembl=ENSBTAG00000009861|UniProtKB=A6H792	FRS3 protein	ISS			PTHR21258:SF39	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 3
P00047	PDGF signaling pathway	P01159	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P02742	Tetrahydrofolate biosynthesis	P02951	GTP cyclohydrolase	AQUAE|EnsemblGenome=aq_239|UniProtKB=O66603	GTP cyclohydrolase 1	ISS			PTHR11109:SF0	GTP CYCLOHYDROLASE 1
P00054	Toll receptor signaling pathway	P01369	MKK1	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06739	MEK1/2	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	RCA	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	DANRE|ZFIN=ZDB-GENE-990415-199|UniProtKB=A3QJX7	Uncharacterized protein	IDA	11259498	PubMed	PTHR24229:SF74	SUBFAMILY NOT NAMED
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00005	Angiogenesis	P00236	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	1504106	PubMed	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00053	T cell activation	P01322	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04397	p53 pathway by glucose deprivation	P04636	S6K	RAT|RGD=1305144|UniProtKB=D4AE24	Ribosomal protein S6 kinase	ISS	15116068	PubMed	PTHR24351:SF171	RIBOSOMAL PROTEIN S6 KINASE BETA-2
P00012	Cadherin signaling pathway	P00470	F-actin	TRIVA|Gene=TVAG_054030|UniProtKB=A2G1K5	Actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00008	Axon guidance mediated by Slit/Robo	P00344	Netrin	MOUSE|MGI=MGI=1934028|UniProtKB=Q8R4G0	Netrin-G1	ISS			PTHR10574:SF28	NETRIN-G1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	11251832	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	PANTR|Gene=CHRM3|UniProtKB=Q9N2A4	Muscarinic acetylcholine receptor M3	TAS	12915051	PubMed	PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00012	Cadherin signaling pathway	P00471	Cadherin	BOVIN|Gene=PCDH18|UniProtKB=A7MB46	Protocadherin-18	ISS	8120095	PubMed	PTHR24028:SF9	PROTOCADHERIN-18
P00047	PDGF signaling pathway	P01142	p90RSK	XENTR|Xenbase=XB-GENE-482409|UniProtKB=F6UK84	Uncharacterized protein (Fragment)	ISS	15116068	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	DROME|FlyBase=FBgn0025595|UniProtKB=Q7KTL9	Adipokinetic hormone receptor, isoform C	IDA			PTHR24241:SF59	ADIPOKINETIC HORMONE RECEPTOR, ISOFORM C
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	DROME|FlyBase=FBgn0001145|UniProtKB=P20478	Glutamine synthetase 2 cytoplasmic	ISS			PTHR20852:SF57	GLUTAMINE SYNTHETASE 2 CYTOPLASMIC
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00860	Rho	HUMAN|HGNC=669|UniProtKB=P08134	Rho-related GTP-binding protein RhoC	ISS	14871999	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00048	PI3 kinase pathway	P01188	Gbetagamma	CRYNJ|EnsemblGenome=CND03830|UniProtKB=Q5KI86	Uncharacterized protein	IGI	10594037	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00056	VEGF signaling pathway	P01417	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00799	JNK-2	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_114535|UniProtKB=C3ZHN2	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00015	Circadian clock system	G01497	cry	MOUSE|MGI=MGI=1270859|UniProtKB=Q9R194	Cryptochrome-2	IEP	10217146	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P02741	Flavin biosynthesis	P02935	GTP cyclohydrolase	FUSNN|EnsemblGenome=FN1508|UniProtKB=Q8RIR1	Riboflavin biosynthesis protein RibBA	ISS			PTHR21327:SF18	3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01181	GSK3	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04393	Ras Pathway	P04557	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IDA	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00036	Interleukin signaling pathway	P00965	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	STRCO|EnsemblGenome=CAA18341|UniProtKB=O69981	Vitamin B12-dependent ribonucleotide reductase	ISS			PTHR43371:SF1	SUBFAMILY NOT NAMED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01439	C-terminal Binding Protein	MACMU|Ensembl=ENSMMUG00000022032|UniProtKB=F7HTC6	Uncharacterized protein	ISS	10375506	PubMed	PTHR10996:SF72	C-TERMINAL-BINDING PROTEIN 2
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P05917	Opioid proopiomelanocortin pathway	P06004	Mu or Delta receptor	BOVIN|Gene=OPRM1|UniProtKB=P79350	Mu-type opioid receptor	RCA	11259487	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00057	Wnt signaling pathway	P01438	PP2A	BOVIN|Ensembl=ENSBTAG00000009245|UniProtKB=Q0P594	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000008306|UniProtKB=F7H6T2	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	BACSU|EnsemblGenome=BSU21810|UniProtKB=P11045	Dihydrofolate reductase	ISS			PTHR22778:SF16	DIHYDROFOLATE REDUCTASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00743	GIRK	ORNAN|Ensembl=ENSOANG00000013961|UniProtKB=F6VPY1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P02722	Acetate utilization	P02803	Acetyl-CoA synthetase	BOVIN|Ensembl=ENSBTAG00000013303|UniProtKB=A7YWF1	ACSS2 protein	ISS			PTHR24095:SF126	ACETYL-COENZYME A SYNTHETASE, CYTOPLASMIC
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	CHICK|Ensembl=ENSGALG00000006126|UniProtKB=P15988	Collagen alpha-2(VI) chain	IC	10778855	PubMed	PTHR44172:SF1	COLLAGEN ALPHA-2 VI  CHAIN
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|RGD=621042|UniProtKB=Q63789	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01224	UbcH7	HUMAN|HGNC=12488|UniProtKB=P68036	Ubiquitin-conjugating enzyme E2 L3	IDA	10888878	PubMed	PTHR24068:SF67	UBIQUITIN-CONJUGATING ENZYME E2 L3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000003828|UniProtKB=H2Q3Z3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IDA	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00005	Angiogenesis	P00246	Ang-2	ORNAN|Ensembl=ENSOANG00000005391|UniProtKB=F6VG66	Uncharacterized protein	ISS	9204896	PubMed	PTHR19143:SF199	ANGIOPOIETIN-2
P00060	Ubiquitin proteasome pathway	P01491	E2	RAT|RGD=1305382|UniProtKB=D3ZUW6	Protein Ube2c	ISS			PTHR44189:SF1	UBIQUITIN-CONJUGATING ENZYME E2 C
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IDA	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00053	T cell activation	P01312	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	11418630	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	IC	15737619	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00637	MKK4,7	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12446777	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	DICDI|dictyBase=DDB_G0275023|UniProtKB=Q553U6	Putative actin-22	IC	3487386	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00020	FAS signaling pathway	P00614	ASK1	HUMAN|HGNC=6857|UniProtKB=Q99683	Mitogen-activated protein kinase kinase kinase 5	TAS			PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05730	Endogenous cannabinoid signaling	P05746	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05912	Dopamine receptor mediated signaling pathway	P05957	K+ channel	HUMAN|HGNC=6278|UniProtKB=O14649	Potassium channel subfamily K member 3	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000012988|UniProtKB=F7HT59	Uncharacterized protein	ISS	18021322	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00036	Interleukin signaling pathway	P00969	Signaling subunit	MACMU|Ensembl=ENSMMUG00000001893|UniProtKB=F7FXC5	Interleukin-6 receptor subunit beta	ISS	10210178	PubMed	PTHR23036:SF83	INTERLEUKIN-6 RECEPTOR SUBUNIT BETA
P00054	Toll receptor signaling pathway	P01358	ERK1	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MACMU|Ensembl=ENSMMUG00000017374|UniProtKB=F7H6T7	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02748	Isoleucine biosynthesis	P02994	Branched chain amino acid aminotransferase	ANOGA|EnsemblGenome=AGAP000011|UniProtKB=Q7QEI9	Branched-chain-amino-acid aminotransferase	ISS			PTHR11825:SF44	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE
P04395	Vasopressin synthesis	P04597	Signal Peptide	CANLF|Ensembl=ENSCAFG00000006432|UniProtKB=F1PZS7	Uncharacterized protein	ISS	1706187	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00045	Notch signaling pathway	P01120	NIcs	RAT|RGD=620761|UniProtKB=Q9R172	Neurogenic locus notch homolog protein 3	ISS	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00049	Parkinson disease	P01212	p38 MAPK	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00034	Integrin signalling pathway	P00925	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	1499729	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00005	Angiogenesis	P00210	eNOS	MACMU|Ensembl=ENSMMUG00000020437|UniProtKB=F6WEB2	Nitric oxide synthase	ISS	9837777	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00009	Axon guidance mediated by netrin	P00363	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00011	Blood coagulation	P00424	uPA	BOVIN|Ensembl=ENSBTAG00000005947|UniProtKB=Q05589	Urokinase-type plasminogen activator	ISS	465014	gi	PTHR24264:SF38	UROKINASE-TYPE PLASMINOGEN ACTIVATOR
P06587	Nicotine pharmacodynamics pathway	P06590	GNG	ORNAN|Ensembl=ENSOANG00000013961|UniProtKB=F6VPY1	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P05916	Opioid prodynorphin pathway	P06001	AC	MOUSE|MGI=MGI=102891|UniProtKB=P51829	Adenylate cyclase type 7	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	XENTR|Xenbase=XB-GENE-479599|UniProtKB=F7DHT4	Uncharacterized protein	ISS	1768802	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00019	Endothelin signaling pathway	P00577	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P02727	Androgen/estrogene/progesterone biosynthesis	P02826	Estradiol 17beta-dehydrogenase	MOUSE|MGI=MGI=1330808|UniProtKB=O88736	3-keto-steroid reductase	RCA			PTHR44442:SF1	3-KETO-STEROID REDUCTASE
P00036	Interleukin signaling pathway	P00970	Interleukin	MACMU|Gene=CXCL8|UniProtKB=P67813	Interleukin-8	IC	124361	gi	PTHR10179:SF70	INTERLEUKIN-8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00048	PI3 kinase pathway	P01199	Galpha	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01472	Histone deacetylase	MOUSE|MGI=MGI=1917565|UniProtKB=Q8VH37	Histone deacetylase 8	IDA	10485845	PubMed	PTHR10625:SF142	HISTONE DEACETYLASE 8
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00029	Huntington disease	P00807	Actin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g234494|UniProtKB=A7RU31	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00059	p53 pathway	G01581	BAX	HUMAN|HGNC=959|UniProtKB=Q07812	Apoptosis regulator BAX	ISS	11099028	PubMed	PTHR11256:SF42	APOPTOSIS REGULATOR BAX
P00005	Angiogenesis	P00251	cPLA2	RAT|RGD=67366|UniProtKB=P50393	Cytosolic phospholipase A2	ISS	9468497	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04393	Ras Pathway	P04559	Rac	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00047	PDGF signaling pathway	P01143	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-9966|UniProtKB=Q6TH03	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	RAT|RGD=620421|UniProtKB=Q9WUF4	Vesicle-associated membrane protein 8	IC	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00057	Wnt signaling pathway	P01449	Nemo-like Kinase	CAEEL|WormBase=WBGene00003048|UniProtKB=Q9U9Y8	Serine/threonine kinase NLK	ISS	10683140	PubMed	PTHR24055:SF344	MITOGEN-ACTIVATED PROTEIN KINASE
P00005	Angiogenesis	P00206	Wnt	ANOGA|EnsemblGenome=AGAP009734|UniProtKB=Q5TP56	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P04393	Ras Pathway	P04558	p38	DROME|FlyBase=FBgn0024846|UniProtKB=O61443	Mitogen-activated protein kinase 14B	ISS	11274345	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	XENTR|Ensembl=ENSXETG00000021375|UniProtKB=F6T423	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000007882|UniProtKB=G3X7Z2	Uncharacterized protein	ISS	15079861	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00053	T cell activation	P01312	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04393	Ras Pathway	P04555	PDK	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04393	Ras Pathway	P04559	Rac	CHICK|Ensembl=ENSGALG00000002859|UniProtKB=F6UBD2	Uncharacterized protein	ISS	15470041	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	RAT|RGD=69319|UniProtKB=P54313	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	ISS	6309843	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	RAT|RGD=61860|UniProtKB=P43425	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00029	Huntington disease	P00788	Calpain	HUMAN|HGNC=1484|UniProtKB=Q9Y6W3	Calpain-7	IDA	11675509	PubMed	PTHR10183:SF22	CALPAIN-7
P00024	Glycolysis	P00677	Hexokinase	HUMAN|HGNC=4923|UniProtKB=P52789	Hexokinase-2	RCA			PTHR19443:SF4	HEXOKINASE-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	1650351	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=11433|UniProtKB=Q16623	Syntaxin-1A	ISS	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	PANTR|Ensembl=ENSPTRG00000015787|UniProtKB=H2QP14	Uncharacterized protein	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05731	GABA-B receptor II signaling	P05753	Ca channel	MOUSE|MGI=MGI=109482|UniProtKB=P97445	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	15699344	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	RAT|RGD=2869|UniProtKB=P24062	Insulin-like growth factor 1 receptor	ISS	2877871	PubMed	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01098	CHT1	MOUSE|MGI=MGI=2384860|UniProtKB=Q921V7	Choline transporter-like protein 3	IC			PTHR12385:SF13	CHOLINE TRANSPORTER-LIKE PROTEIN 3
P00053	T cell activation	P01318	PKC-theta	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00048	PI3 kinase pathway	P01178	Grb2	CAEBR|Gene=CBG16856|UniProtKB=A8XPY6	Protein CBR-SEM-5	ISS	8307166	PubMed	PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	PANTR|Ensembl=ENSPTRG00000015026|UniProtKB=H2QMT0	Uncharacterized protein	ISS	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	12434148	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	BOVIN|Ensembl=ENSBTAG00000035370|UniProtKB=Q32LB1	TATA box-binding protein-like protein 1	ISS	10082669	PubMed	PTHR10126:SF32	TATA BOX-BINDING PROTEIN-LIKE PROTEIN 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P02747	Histidine biosynthesis	P02992	Imidazol glycerol phosphate synthase	AQUAE|EnsemblGenome=aq_181|UniProtKB=O66567	Imidazole glycerol phosphate synthase subunit HisF	ISS			PTHR21235:SF2	IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000002741|UniProtKB=H2Q292	Uncharacterized protein	ISS			PTHR24247:SF116	5-HYDROXYTRYPTAMINE RECEPTOR 7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	HUMAN|HGNC=9441|UniProtKB=P51817	cAMP-dependent protein kinase catalytic subunit PRKX	ISS	14744463	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PRIPA|Gene=PPA23459|UniProtKB=H3FMF2	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00021	FGF signaling pathway	P00642	MEK1-2	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00049	Parkinson disease	P01238	14-3-3	XENTR|Xenbase=XB-GENE-951350|UniProtKB=Q0V9W8	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	ISS	9507245	gi	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P05918	p38 MAPK pathway	P06030	IL-1R	PANTR|Ensembl=ENSPTRG00000012299|UniProtKB=H2QIG4	Uncharacterized protein	ISS			PTHR11890:SF26	INTERLEUKIN-1 RECEPTOR TYPE 1
P00034	Integrin signalling pathway	P00906	Rap1	HUMAN|HGNC=9862|UniProtKB=P61225	Ras-related protein Rap-2b	IC	8576107	PubMed	PTHR24070:SF194	RAS-RELATED PROTEIN RAP-2B
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=101948|UniProtKB=P48615	Protein Wnt-11	IDA	8717036	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	PANTR|Ensembl=ENSPTRG00000001827|UniProtKB=H2Q0V5	Uncharacterized protein	ISS	15737619	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000013241|UniProtKB=H2QJY4	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00021	FGF signaling pathway	P00629	PP2A	ORNAN|Ensembl=ENSOANG00000009097|UniProtKB=F7G755	Uncharacterized protein	ISS	8703017	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00021	FGF signaling pathway	P00628	JNK1-3	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00029	Huntington disease	P00807	Actin	ENTHI|EnsemblGenome=EHI_107290|UniProtKB=B1N2P0	Actin	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P06664	Gonadotropin-releasing hormone receptor pathway	P06852	nPKCs	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	CRYNJ|EnsemblGenome=CND03830|UniProtKB=Q5KI86	Uncharacterized protein	ISS	10594037	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P06959	CCKR signaling map	P07232	CREB1	HUMAN|HGNC=2345|UniProtKB=P16220	Cyclic AMP-responsive element-binding protein 1	RCA	7935349	PubMed	PTHR22952:SF200	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00947	Laminin	MOUSE|MGI=MGI=1344394|UniProtKB=Q9R0B6	Laminin subunit gamma-3	IPI	2538453	PubMed	PTHR10574:SF240	LAMININ SUBUNIT GAMMA-3
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	IDA	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	PANTR|Ensembl=ENSPTRG00000009415|UniProtKB=H2QDG2	Nucleoside diphosphate kinase	ISS			PTHR11349:SF69	NUCLEOSIDE DIPHOSPHATE KINASE A
P05913	Enkephalin release	P05977	G-Protein (s)	DANRE|ZFIN=ZDB-GENE-040426-2280|UniProtKB=Q6P025	Gnb3 protein	ISS			PTHR19850:SF35	GNB3 PROTEIN
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	MACMU|Ensembl=ENSMMUG00000002134|UniProtKB=F6UNV6	Ribosomal protein S6 kinase	ISS	2779569	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00034	Integrin signalling pathway	P00925	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01063	CAT	CAEEL|WormBase=WBGene00000481|UniProtKB=P32756	Choline O-acetyltransferase	ISS	97225904	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06852	nPKCs	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	PANTR|Ensembl=ENSPTRG00000009322|UniProtKB=H2REI3	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF84	PROTEIN WNT-9B
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00010	B cell activation	P00371	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00274	JNK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	MOUSE|MGI=MGI=2443036|UniProtKB=Q8CFP6	DnaJ homolog subfamily C member 27	ISS			PTHR24073:SF269	DNAJ HOMOLOG SUBFAMILY C MEMBER 27
P00053	T cell activation	P01315	Calcineurin	MOUSE|MGI=MGI=107164|UniProtKB=P63328	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	ISS	7532676	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02727	Androgen/estrogene/progesterone biosynthesis	P02826	Estradiol 17beta-dehydrogenase	RAT|RGD=708343|UniProtKB=O54753	17-beta-hydroxysteroid dehydrogenase type 6	RCA			PTHR43313:SF4	17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 6
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=1306348|UniProtKB=F1LS01	Protein Pcdh9	ISS	8120095	PubMed	PTHR43912:SF5	PROTOCADHERIN-9
P00034	Integrin signalling pathway	P00942	Fyn	RAT|RGD=2641|UniProtKB=Q62844	Tyrosine-protein kinase Fyn	IPI	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00012	Cadherin signaling pathway	P00471	Cadherin	XENTR|Xenbase=XB-GENE-5887886|UniProtKB=F6VDD4	Uncharacterized protein (Fragment)	ISS	8120095	PubMed	PTHR24028:SF46	PROTOCADHERIN-8
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	MACMU|Ensembl=ENSMMUG00000018272|UniProtKB=F7HEB8	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	CANLF|Ensembl=ENSCAFG00000005109|UniProtKB=Q3LSL6	C-X-C chemokine receptor type 4	ISS	4503175	gi	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P00021	FGF signaling pathway	P00648	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04384	Gamma-aminobutyric acid synthesis	P04482	Glutamate decarboxylase	CANLF|Ensembl=ENSCAFG00000007077|UniProtKB=F1PKT4	Uncharacterized protein	ISS			PTHR11999:SF114	CYSTEINE SULFINIC ACID DECARBOXYLASE
P04398	p53 pathway feedback loops 2	P04665	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	IDA	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00011	Blood coagulation	P00444	FIX	MOUSE|MGI=MGI=88384|UniProtKB=P16294	Coagulation factor IX	ISS	119773	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	TAS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	MACMU|Ensembl=ENSMMUG00000023470|UniProtKB=F6V2U8	Uncharacterized protein	RCA			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00017	DNA replication	P00534	PCNA	PLAF7|EnsemblGenome=PF13_0328|UniProtKB=P61074	Proliferating cell nuclear antigen	ISS	93181197	PubMed	PTHR11352:SF0	PROLIFERATING CELL NUCLEAR ANTIGEN
P00019	Endothelin signaling pathway	P00570	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00047	PDGF signaling pathway	P01165	SRF	MACMU|Ensembl=ENSMMUG00000000033|UniProtKB=F7G4D2	Uncharacterized protein	ISS	8660892	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00029	Huntington disease	P00780	Microtubule	HUMAN|HGNC=12412|UniProtKB=Q13885	Tubulin beta-2A chain	IDA	12932731	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P00036	Interleukin signaling pathway	P00964	p90RSK	RAT|RGD=1563860|UniProtKB=D3Z8E0	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05730	Endogenous cannabinoid signaling	P05750	Ca2+ channel	MOUSE|MGI=MGI=88296|UniProtKB=O55017	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	14507926	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00006	Apoptosis signaling pathway	P00274	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MONDO|Ensembl=ENSMODG00000016960|UniProtKB=F6V5G0	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	MACMU|Ensembl=ENSMMUG00000022577|UniProtKB=Q866A2	Neuronal acetylcholine receptor subunit alpha-7	ISS	11404397	PubMed	PTHR18945:SF572	CHRNA7-FAM7A FUSION PROTEIN-RELATED
P04393	Ras Pathway	P04547	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00972	MNK1/2	RAT|RGD=1559603|UniProtKB=Q4G050	MAP kinase-interacting serine/threonine-protein kinase 1	ISS	11575158	PubMed	PTHR24349:SF114	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
P00046	Oxidative stress response	P01135	p38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	TAS	9548470	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P02742	Tetrahydrofolate biosynthesis	P02943	Dihydrofolate synthase	ARATH|TAIR=AT2G16370|UniProtKB=Q05762	Bifunctional dihydrofolate reductase-thymidylate synthase 1	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00570	PKA	NEUCR|EnsemblGenome=EFNCRG00000004240|UniProtKB=Q01386	cAMP-dependent protein kinase regulatory subunit	IGI	91298951	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00840	GPRK	MOUSE|MGI=MGI=87940|UniProtKB=Q99MK8	Beta-adrenergic receptor kinase 1	IDA	10085131	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00936	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	IPI	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	MOUSE|MGI=MGI=99473|UniProtKB=Q8BWG8	Beta-arrestin-1	ISS	11742073	PubMed	PTHR11792:SF22	BETA-ARRESTIN-1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00047	PDGF signaling pathway	P01171	PLCgamma	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01067	AChE	BRAFL|Gene=BRAFLDRAFT_116869|UniProtKB=C3ZD75	Carboxylic ester hydrolase	ISS	86008285	PubMed	PTHR11559:SF356	ACETYLCHOLINESTERASE
P02736	Coenzyme A biosynthesis	P02882	Pantothenate cysteine ligase	BACSU|EnsemblGenome=BSU15700|UniProtKB=O35033	Probable coenzyme A biosynthesis bifunctional protein CoaBC	ISS			PTHR14359:SF6	PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DICDI|dictyBase=DDB_G0283907|UniProtKB=P34099	cAMP-dependent protein kinase catalytic subunit	ISS	10218114	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P02742	Tetrahydrofolate biosynthesis	P02948	Dihydrofolate reductase	CAEEL|WormBase=WBGene00007974|UniProtKB=Q93341	Putative dihydrofolate reductase	ISS			PTHR22778:SF16	DIHYDROFOLATE REDUCTASE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00053	T cell activation	P01330	IKK	HUMAN|HGNC=5960|UniProtKB=O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	IGI	12813046	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	DICPU|Gene=DICPUDRAFT_93216|UniProtKB=F1A421	Guanine nucleotide-binding protein subunit beta	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00029	Huntington disease	P00790	beta-Tubulin	BOVIN|Ensembl=ENSBTAG00000023730|UniProtKB=Q2T9S0	Tubulin beta-3 chain	ISS	9454836	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	TAS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00052	TGF-beta signaling pathway	P01275	P38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	TAS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02740	De novo pyrimidine ribonucleotides biosythesis	P02929	CDP kinase	CHLTR|EnsemblGenome=CT_500|UniProtKB=O84508	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00020	FAS signaling pathway	P00620	CytochromeC	SCHPO|PomBase=SPBC29A3.18|UniProtKB=O59680	Cytochrome c1, heme protein, mitochondrial	IGI	15163634	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	10188796	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P04392	P53 pathway feedback loops 1	P04537	p73DeltaN	RAT|RGD=620863|UniProtKB=Q9JJP6	Tumor protein 63	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00005	Angiogenesis	P00190	RasGAP	RAT|RGD=3537|UniProtKB=P50904	Ras GTPase-activating protein 1	ISS	8262392	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P02778	Sulfate assimilation	P03167	Sulfate adenylyltransferase	MACMU|Ensembl=ENSMMUG00000006411|UniProtKB=F7HUI6	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform a	ISS			PTHR11055:SF16	BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE 2
P00019	Endothelin signaling pathway	P00580	ET-RA/B	CANLF|Gene=EDNRA|UniProtKB=Q5KSU9	Endothelin-1 receptor	ISS	8564193	PubMed	PTHR24243:SF31	ENDOTHELIN-1 RECEPTOR
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CAEEL|WormBase=WBGene00004039|UniProtKB=Q21754	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF147	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-2
P00057	Wnt signaling pathway	P01443	Phospholipase C	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IDA	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=1351345|UniProtKB=P47743	Metabotropic glutamate receptor 8	IDA	12488551	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00746	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00059	p53 pathway	P01486	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	TAS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05918	p38 MAPK pathway	P06015	p38gamma	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	RCA	11274345	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00049	Parkinson disease	P01227	20S proteasome	PANTR|Ensembl=ENSPTRG00000031165|UniProtKB=H2R3I7	Proteasome subunit beta type	ISS	12859888	PubMed	PTHR11599:SF41	PROTEASOME SUBUNIT BETA TYPE-10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	DANRE|Ensembl=ENSDARG00000059090|UniProtKB=E7FDL0	Uncharacterized protein	ISS			PTHR24229:SF75	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00990	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00206	Wnt	RAT|RGD=69250|UniProtKB=Q9QXQ7	Protein Wnt-5a	ISS	11266476	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00029	Huntington disease	P00805	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	RAT|RGD=71000|UniProtKB=Q9JLT0	Myosin-10	ISS	89264452	PubMed	PTHR13140:SF328	MYOSIN-10
P00057	Wnt signaling pathway	P01446	Calcineurin	DROME|FlyBase=FBgn0015614|UniProtKB=Q24214	Calcineurin subunit B type 2	IDA	12015605	PubMed	PTHR23056:SF4	PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1
P00005	Angiogenesis	P00203	Erk	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	12471242	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04392	P53 pathway feedback loops 1	P04539	p53	ORNAN|Ensembl=ENSOANG00000013795|UniProtKB=F7DUR2	Uncharacterized protein (Fragment)	ISS	15197326	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P00056	VEGF signaling pathway	P01417	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	BOVIN|Ensembl=ENSBTAG00000004368|UniProtKB=F1MSU2	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00023	General transcription regulation	P00668	TFIIB	HALSA|EnsemblGenome=VNG_6351G|UniProtKB=Q9HHK5	Transcription initiation factor IIB 3	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000008719|UniProtKB=F1MZX0	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00021	FGF signaling pathway	P00629	PP2A	YEAST|SGD=S000000014|UniProtKB=P31383	Protein phosphatase PP2A regulatory subunit A	ISS			PTHR10648:SF4	PROTEIN PHOSPHATASE 2  FORMERLY 2A , REGULATORY SUBUNIT A, BETA ISOFORM
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00057	Wnt signaling pathway	P01452	NFAT	RAT|RGD=1307690|UniProtKB=D4A0I8	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (Predicted), isoform CRA_b	ISS	9462517	PubMed	PTHR12533:SF4	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2
P00052	TGF-beta signaling pathway	P01289	I-Smads	MOUSE|MGI=MGI=1100518|UniProtKB=O35253	Mothers against decapentaplegic homolog 7	IGI	9335505	PubMed	PTHR13703:SF27	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 7
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	MOUSE|MGI=MGI=106684|UniProtKB=Q8R090	Chromaffin granule amine transporter	ISS	12135927	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P00004	Alzheimer disease-presenilin pathway	P00120	Notch C-terminal fragment	BOVIN|Ensembl=ENSBTAG00000043971|UniProtKB=E1BPT8	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00004	Alzheimer disease-presenilin pathway	P00123	CD44 C-terminal fragment	PANTR|Ensembl=ENSPTRG00000003501|UniProtKB=H2Q3E8	Uncharacterized protein	ISS	12223485	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	ISS	10327594	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00005	Angiogenesis	P00206	Wnt	XENTR|Xenbase=XB-GENE-485280|UniProtKB=F6X3B2	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P02738	De novo purine biosynthesis	P02891	GDP kinase	RAT|RGD=619879|UniProtKB=G3V816	Nucleoside diphosphate kinase	ISS			PTHR11349:SF54	NUCLEOSIDE DIPHOSPHATE KINASE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	4757952	gi	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00037	Ionotropic glutamate receptor pathway	P00999	PSD95	HUMAN|HGNC=14294|UniProtKB=Q9BYB0	SH3 and multiple ankyrin repeat domains protein 3	ISS	20020275	PubMed	PTHR24135:SF4	SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN 3
P00006	Apoptosis signaling pathway	P00310	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01312	MEK	PANTR|Ensembl=ENSPTRG00000010294|UniProtKB=H2QF06	Uncharacterized protein	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	PANTR|Ensembl=ENSPTRG00000002052|UniProtKB=H2R821	Presenilin	ISS	9332390	PubMed	PTHR10202:SF13	PRESENILIN-2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PANTR|Ensembl=ENSPTRG00000010658|UniProtKB=H2RDA5	Uncharacterized protein	ISS			PTHR13140:SF306	UNCONVENTIONAL MYOSIN-IXB
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00018	EGF receptor signaling pathway	P00565	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00029	Huntington disease	P00807	Actin	DICDI|dictyBase=DDB_G0289487|UniProtKB=P07829	Actin-3	IDA	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P05913	Enkephalin release	P05977	G-Protein (s)	MACMU|Ensembl=ENSMMUG00000017374|UniProtKB=F7H6T7	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00010	B cell activation	P00402	Jnk	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P05913	Enkephalin release	P05972	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00021	FGF signaling pathway	P00642	MEK1-2	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	8388392	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	RAT|RGD=3693|UniProtKB=Q01818	Chromaffin granule amine transporter	ISS	12135927	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00047	PDGF signaling pathway	P01143	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00006	Apoptosis signaling pathway	P00260	AKT	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	DROME|FlyBase=FBgn0039747|UniProtKB=Q9VAA2	Adenosine receptor, isoform A	IDA	12515326	PubMed	PTHR24246:SF27	ADENOSINE RECEPTOR A2A
P02763	Peptidoglycan biosynthesis	P03088	UDP-N-acetylmuramate dehydrogenase	AQUAE|EnsemblGenome=aq_520|UniProtKB=O66805	UDP-N-acetylenolpyruvoylglucosamine reductase	ISS			PTHR21071:SF4	UDP-N-ACETYLENOLPYRUVOYLGLUCOSAMINE REDUCTASE
P00047	PDGF signaling pathway	P01167	Ets	PANTR|Ensembl=ENSPTRG00000004466|UniProtKB=H2RCM3	Uncharacterized protein	ISS	15298723	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00029	Huntington disease	P00797	p53	CANLF|Ensembl=ENSCAFG00000017484|UniProtKB=F1PMM7	Uncharacterized protein	ISS			PTHR12195:SF1	CYTOPLASMIC FMR1-INTERACTING PROTEIN 2
P02738	De novo purine biosynthesis	P02911	N5-carboxyaminoimidazole ribonucleotide mutase	BACSU|EnsemblGenome=BSU06420|UniProtKB=P12044	N5-carboxyaminoimidazole ribonucleotide mutase	ISS			PTHR23046:SF2	N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE MUTASE
P00007	Axon guidance mediated by semaphorins	P00339	CRMP	MACMU|Ensembl=ENSMMUG00000019563|UniProtKB=F7BMS3	Dihydropyrimidinase-related protein 1 isoform 2	ISS	96424532	PubMed	PTHR11647:SF54	DIHYDROPYRIMIDINASE-RELATED PROTEIN 1
P00036	Interleukin signaling pathway	P00981	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	TAS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	PANTR|Ensembl=ENSPTRG00000013021|UniProtKB=G2HJQ1	26S proteasome non-ATPase regulatory subunit 1	ISS			PTHR10943:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=98957|UniProtKB=P22724	Protein Wnt-4	IDA	11266476	PubMed	PTHR12027:SF101	PROTEIN WNT-4
P00010	B cell activation	P00371	ERK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	8392888	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00627	ERK1-2	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02736	Coenzyme A biosynthesis	P02884	Dephospho-CoA kinase	PSEAE|EnsemblGenome=PA4529|UniProtKB=Q9HVP8	Dephospho-CoA kinase	ISS			PTHR10695:SF26	BIFUNCTIONAL COENZYME A SYNTHASE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05731	GABA-B receptor II signaling	P05755	Gbeta	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS	6309843	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00057	Wnt signaling pathway	P01443	Phospholipase C	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IDA	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00056	VEGF signaling pathway	P01423	p38MAPK	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=98954|UniProtKB=P21552	Protein Wnt-2	TAS	8717036	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DROME|FlyBase=FBgn0004435|UniProtKB=P23625	G protein alpha q subunit	IC	9166716	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	DROME|FlyBase=FBgn0004619|UniProtKB=Q03445	Glutamate receptor 1	IC	12941441	PubMed	PTHR18966:SF270	GLUTAMATE RECEPTOR 1-RELATED
P00005	Angiogenesis	P00195	APC	PANTR|Ensembl=ENSPTRG00000017135|UniProtKB=H2QRB5	Adenomatous polyposis coli	ISS	12549854	PubMed	PTHR12607:SF11	ADENOMATOUS POLYPOSIS COLI PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	PANTR|Ensembl=ENSPTRG00000002064|UniProtKB=H2R817	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P00054	Toll receptor signaling pathway	P01346	TLR	HUMAN|HGNC=15632|UniProtKB=Q9NR97	Toll-like receptor 8	ISS			PTHR44312:SF2	TOLL-LIKE RECEPTOR 8
P00009	Axon guidance mediated by netrin	P00363	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	129387	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00055	Transcription regulation by bZIP transcription factor	P01387	CBP/P300	PANTR|Ensembl=ENSPTRG00000014418|UniProtKB=H2QLS0	Uncharacterized protein	ISS	10664585	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	DROME|FlyBase=FBgn0004573|UniProtKB=P20905	5-hydroxytryptamine receptor 1	IDA			PTHR24247:SF171	5-HYDROXYTRYPTAMINE RECEPTOR 1
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	DANRE|ZFIN=ZDB-GENE-980526-6|UniProtKB=Q5BJ08	Homeobox protein engrailed-like	IEP	12356903	PubMed	PTHR24341:SF4	HOMEOBOX PROTEIN ENGRAILED-1
P04398	p53 pathway feedback loops 2	P04651	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00050	Plasminogen activating cascade	P01249	pro-tPA	HUMAN|HGNC=9051|UniProtKB=P00750	Tissue-type plasminogen activator	IDA	4505861	gi	PTHR44617:SF1	TISSUE-TYPE PLASMINOGEN ACTIVATOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IDA	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	ANOGA|EnsemblGenome=AGAP005913|UniProtKB=Q7Q6D2	AGAP005913-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00626	Spry	RAT|RGD=1305324|UniProtKB=D3ZJA3	Protein Spry4	ISS	10330503	PubMed	PTHR12365:SF6	PROTEIN SPROUTY HOMOLOG 4
P00060	Ubiquitin proteasome pathway	P01490	E3	MACMU|Ensembl=ENSMMUG00000000628|UniProtKB=F6RKN5	Ubiquitin-protein ligase E3A isoform 3	ISS			PTHR11254:SF301	UBIQUITIN-PROTEIN LIGASE E3A
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	TAS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00034	Integrin signalling pathway	P00951	Jnk	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05913	Enkephalin release	G06046	preproenkephalin mRNA	HUMAN|HGNC=8831|UniProtKB=P01210	Proenkephalin-A	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00029	Huntington disease	P00781	Dynactin	BOVIN|Ensembl=ENSBTAG00000004887|UniProtKB=F1MIC9	Uncharacterized protein	ISS	9454836	PubMed	PTHR18916:SF40	DYNACTIN SUBUNIT 1
P00018	EGF receptor signaling pathway	P00564	Rac	CAEEL|WormBase=WBGene00004287|UniProtKB=Q94124	Ras-related protein rac-2	IGI	4757952	gi	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00054	Toll receptor signaling pathway	P01358	ERK1	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00552	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IGI	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00060	Ubiquitin proteasome pathway	P01491	E2	SCHPO|PomBase=SPBC1198.09|UniProtKB=Q9P6I1	Ubiquitin-conjugating enzyme E2 16	ISS			PTHR43898:SF3	SUBFAMILY NOT NAMED
P00053	T cell activation	P01336	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	14532003	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00015	Circadian clock system	G01500	bmal1	MOUSE|MGI=MGI=1096381|UniProtKB=Q9WTL8	Aryl hydrocarbon receptor nuclear translocator-like protein 1	ISS	11163178	PubMed	PTHR23042:SF52	ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 1
P00038	JAK/STAT signaling pathway	P01027	STAT	MOUSE|MGI=MGI=103035|UniProtKB=P42232	Signal transducer and activator of transcription 5B	ISS	22320921	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00018	EGF receptor signaling pathway	P00559	MEK1-2	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IGI	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	TAS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00029	Huntington disease	P00772	FIP-2	HUMAN|HGNC=17260|UniProtKB=O95379	Tumor necrosis factor alpha-induced protein 8	IDA			PTHR12757:SF3	TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 8
P00034	Integrin signalling pathway	P00924	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000011757|UniProtKB=Q9XT97	Presenilin-1	TAS	8755489	PubMed	PTHR10202:SF18	PRESENILIN-1
P00034	Integrin signalling pathway	P00916	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DICPU|Gene=DICPUDRAFT_90232|UniProtKB=F1A175	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00021	FGF signaling pathway	P00648	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00005	Angiogenesis	P00181	SHP2	CHICK|Ensembl=ENSGALG00000004821|UniProtKB=Q90687	Tyrosine-protein phosphatase non-receptor type 11	ISS	1382983	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	DANRE|ZFIN=ZDB-GENE-060512-98|UniProtKB=B1NA68	Mitogen-activated protein kinase kinase 4A	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02757	O-antigen biosynthesis	P03051	Fructose-6-phosphate aminotransferase	METJA|EnsemblGenome=MJ_1420|UniProtKB=Q58815	Glutamine--fructose-6-phosphate aminotransferase [isomerizing]	ISS			PTHR10937:SF0	GH12731P-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00036	Interleukin signaling pathway	P00983	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00627	ERK1-2	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04398	p53 pathway feedback loops 2	P04654	Rb	PANTR|Ensembl=ENSPTRG00000013469|UniProtKB=H2QKB0	Retinoblastoma-like 1 (P107)	ISS			PTHR13742:SF20	RETINOBLASTOMA-LIKE PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00589	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	CAEEL|WormBase=WBGene00001680|UniProtKB=Q20636	Guanine nucleotide-binding protein subunit beta-2	IC			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00021	FGF signaling pathway	P00644	p38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	9430721	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00036	Interleukin signaling pathway	P00983	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P02788	Xanthine and guanine salvage pathway	P03247	Xanthine phosphoribosyl transferase	CHICK|Gene=HPRT1|UniProtKB=Q9W719	Hypoxanthine-guanine phosphoribosyltransferase	ISS			PTHR43340:SF6	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE
P00021	FGF signaling pathway	P00627	ERK1-2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00048	PI3 kinase pathway	P01197	Caspase-9	PANTR|Ensembl=ENSPTRG00000000200|UniProtKB=H2PY35	Caspase	ISS	11440972	PubMed	PTHR10454:SF157	CASPASE-9
P00007	Axon guidance mediated by semaphorins	P00337	Sema3A	HUMAN|HGNC=10723|UniProtKB=Q14563	Semaphorin-3A	ISS			PTHR11036:SF23	SEMAPHORIN-3A
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PLAF7|EnsemblGenome=PF11_0147|UniProtKB=Q7KQK7	Mitogen-activated protein kinase	IGI	10851062	PubMed	PTHR24055:SF189	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00020	FAS signaling pathway	P00601	c-Jun	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	BOVIN|Ensembl=ENSBTAG00000016097|UniProtKB=E1B9S9	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	HUMAN|HGNC=6015|UniProtKB=P24394	Interleukin-4 receptor subunit alpha	IC	2278997	PubMed	PTHR23037:SF32	INTERLEUKIN-4 RECEPTOR SUBUNIT ALPHA
P00060	Ubiquitin proteasome pathway	P01491	E2	MACMU|Ensembl=ENSMMUG00000008940|UniProtKB=F7EVY1	Uncharacterized protein	ISS	10888878	PubMed	PTHR24068:SF67	UBIQUITIN-CONJUGATING ENZYME E2 L3
P00048	PI3 kinase pathway	P01188	Gbetagamma	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	SCHPO|PomBase=SPAC1687.15|UniProtKB=Q10452	Protein kinase gsk3	TAS			PTHR24057:SF0	PROTEIN KINASE SHAGGY-RELATED
P00010	B cell activation	P00386	Calcineurin	MACMU|Ensembl=ENSMMUG00000004599|UniProtKB=F6Q932	Serine/threonine-protein phosphatase	ISS	12015605	PubMed	PTHR11668:SF312	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00197	Grb14	BOVIN|Gene=GRB14|UniProtKB=Q5ICW4	Growth factor receptor-bound protein 14	ISS	10521483	PubMed	PTHR11243:SF22	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 14
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P05915	Opioid proenkephalin pathway	P05995	proenkephalin	XENTR|Xenbase=XB-GENE-942760|UniProtKB=F6Y5F6	Uncharacterized protein	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	10799299	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	PHYPA|Gene=PHYPADRAFT_218940|UniProtKB=A9T4Y7	Predicted protein	ISS	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	9298898	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01160	IP3 receptor	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00004	Alzheimer disease-presenilin pathway	P00156	beta-catenin	MONDO|Ensembl=ENSMODG00000011192|UniProtKB=F6SRK5	Uncharacterized protein	ISS	11532955	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00047	PDGF signaling pathway	P01156	PDGF receptor B	RAT|RGD=3285|UniProtKB=Q05030	Platelet-derived growth factor receptor beta	RCA			PTHR24416:SF53	PLATELET-DERIVED GROWTH FACTOR RECEPTOR BETA
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	HUMAN|HGNC=363|UniProtKB=P27144	Adenylate kinase 4, mitochondrial	ISS			PTHR23359:SF58	ADENYLATE KINASE 4, MITOCHONDRIAL
P00029	Huntington disease	P00801	Fos protein	BOVIN|Ensembl=ENSBTAG00000004322|UniProtKB=O77628	Proto-oncogene c-Fos	TAS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	ISS	9931261	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01438	PP2A	CAEEL|WormBase=WBGene00012348|UniProtKB=O18178	Protein Phosphatase 2A (Two A) Regulatory subunit	IDA			PTHR10257:SF29	BCDNA.LD34343
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	MACMU|Ensembl=ENSMMUG00000003275|UniProtKB=F7FKL1	Serine/threonine-protein kinase PAK 7	ISS			PTHR24361:SF183	SERINE/THREONINE-PROTEIN KINASE PAK 7
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P02734	Chorismate biosynthesis	P02873	Shikimate dehydrogenase	STRCO|Gene=CAB93378|UniProtKB=Q9KXQ2	Shikimate 5-dehydrogenase	ISS			PTHR21089:SF1	BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE/SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC
P04393	Ras Pathway	P04568	MKK3/6	DANRE|ZFIN=ZDB-GENE-010202-3|UniProtKB=Q9DGE0	Dual specificity mitogen-activated protein kinase kinase 6	ISS			PTHR24361:SF645	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	CHICK|Ensembl=ENSGALG00000004693|UniProtKB=Q5ZJI7	Uncharacterized protein	ISS	12932731	PubMed	PTHR10709:SF11	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1A
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	CAEBR|Gene=CBG05858|UniProtKB=A8X1H0	Protein CBR-EGL-19 (Fragment)	ISS	91056091	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Gene=DRD2|UniProtKB=P60026	D(2) dopamine receptor	ISS	2137198	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	MACMU|Ensembl=ENSMMUG00000009600|UniProtKB=F7AC65	Uncharacterized protein	ISS	2255909	PubMed	PTHR11920:SF291	ADENYLATE CYCLASE TYPE 3
P00049	Parkinson disease	P01219	SAPK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00009	Axon guidance mediated by netrin	P00356	UNC-5	PANTR|Ensembl=ENSPTRG00000017569|UniProtKB=H2R550	Uncharacterized protein	ISS			PTHR12582:SF4	NETRIN RECEPTOR UNC5A
P02756	N-acetylglucosamine metabolism	P03039	Glucosamine-1-phosphate acetyltransferase	RHOBA|EnsemblGenome=RB6841|UniProtKB=Q7UPM5	UDP-N-acetylglucosamine pyrophosphorylase	ISS			PTHR43584:SF3	BIFUNCTIONAL PROTEIN GLMU
P00006	Apoptosis signaling pathway	P00272	ASK1	MOUSE|MGI=MGI=1346876|UniProtKB=O35099	Mitogen-activated protein kinase kinase kinase 5	ISS	8974401	PubMed	PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00009	Axon guidance mediated by netrin	P00360	DCC/UNC-40	PANTR|Ensembl=ENSPTRG00000010031|UniProtKB=H2QEJ8	Uncharacterized protein	ISS	12810718	PubMed	PTHR44146:SF3	NETRIN RECEPTOR DCC
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00705	Gsalpha	MONDO|Ensembl=ENSMODG00000021434|UniProtKB=F7CB49	Uncharacterized protein	ISS	2106672	PubMed	PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IDA	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00057	Wnt signaling pathway	P01471	alpha-catenin	MACMU|Ensembl=ENSMMUG00000000293|UniProtKB=F6YFG3	Uncharacterized protein	ISS	9362521	PubMed	PTHR18914:SF23	CATENIN ALPHA-2
P00057	Wnt signaling pathway	P01428	Frizzled	MACMU|Ensembl=ENSMMUG00000013656|UniProtKB=F7GI70	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF126	FRIZZLED-5
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	DANRE|ZFIN=ZDB-GENE-040426-2280|UniProtKB=Q6P025	Gnb3 protein	ISS			PTHR19850:SF35	GNB3 PROTEIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Ensembl=ENSCAFG00000032542|UniProtKB=J9P639	Uncharacterized protein	ISS	11259498	PubMed	PTHR24229:SF1	KAPPA-TYPE OPIOID RECEPTOR
P00006	Apoptosis signaling pathway	P00269	MAPK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00805	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02772	Pyruvate metabolism	P03133	Pyruvate Dehydrogenase	CHLTR|EnsemblGenome=CT_245|UniProtKB=O84247	Pyruvate dehydrogenase E1 component subunit alpha	ISS	10684935	PubMed	PTHR11516:SF53	SUBFAMILY NOT NAMED
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000022548|UniProtKB=F6Y9J9	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	XENTR|Xenbase=XB-GENE-963560|UniProtKB=Q0VFC4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00056	VEGF signaling pathway	P01423	p38MAPK	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00029	Huntington disease	P00796	Kainate receptor	MONDO|Ensembl=ENSMODG00000018065|UniProtKB=F7G485	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00018	EGF receptor signaling pathway	P00564	Rac	ENTHI|EnsemblGenome=EHI_070730|UniProtKB=C4M5T0	Rho family GTPase	IGI	12932731	PubMed	PTHR24072:SF117	RHO-RELATED PROTEIN RACC
P02771	Pyrimidine Metabolism	P03124	Methylmalonate Semialdehyde Dehydrogenase	MYCTU|EnsemblGenome=LH57_04085|UniProtKB=O53816	Methylmalonate-semialdehyde dehydrogenase	ISS	9634230	PubMed	PTHR43866:SF4	SUBFAMILY NOT NAMED
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DANRE|ZFIN=ZDB-GENE-050417-267|UniProtKB=F1QUN8	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF263	ACTIN
P00018	EGF receptor signaling pathway	P00562	p38	RAT|RGD=70975|UniProtKB=Q63538	Mitogen-activated protein kinase 12	IGI	10851062	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00048	PI3 kinase pathway	P01199	Galpha	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IC	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05915	Opioid proenkephalin pathway	P05994	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10188796	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00012	Cadherin signaling pathway	P00475	Frizzled	DANRE|ZFIN=ZDB-GENE-990415-224|UniProtKB=F1QBI2	Uncharacterized protein	IDA	11212302	PubMed	PTHR11309:SF34	FRIZZLED-2
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00005	Angiogenesis	P00238	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	12483530	PubMed	PTHR24070:SF189	GTPASE NRAS
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00024	Glycolysis	P00679	Aldolase	RAT|RGD=1359133|UniProtKB=Q6AY07	Fructose-bisphosphate aldolase	ISS	84261525	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P05730	Endogenous cannabinoid signaling	P05746	PLC	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00029	Huntington disease	P00807	Actin	BOVIN|Ensembl=ENSBTAG00000014614|UniProtKB=P62739	Actin, aortic smooth muscle	ISS	11889139	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00003	Alzheimer disease-amyloid secretase pathway	P00106	C99	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MOUSE|MGI=MGI=109356|UniProtKB=O09044	Synaptosomal-associated protein 23	IC	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00057	Wnt signaling pathway	P01451	Galpha	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	8836152	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P02738	De novo purine biosynthesis	P02909	GDP reductase	MYCTU|EnsemblGenome=Rv3051c|UniProtKB=P9WH75	Ribonucleoside-diphosphate reductase subunit alpha	ISS			PTHR11573:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 SUBUNIT ALPHA
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008026|UniProtKB=H2QAZ2	Syntaxin 1B	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00036	Interleukin signaling pathway	P00981	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	9744561	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00006	Apoptosis signaling pathway	P00260	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11907032	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00311	GCKR	DROME|FlyBase=FBgn0263395|UniProtKB=A1ZBH7	Happyhour, isoform A	ISS			PTHR24361:SF413	HAPPYHOUR, ISOFORM A
P00006	Apoptosis signaling pathway	P00260	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	93173519	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	10433257	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00019	Endothelin signaling pathway	P00571	Pro ET1-4	RAT|RGD=2533|UniProtKB=P23943	Endothelin-2	ISS	8201007	PubMed	PTHR13874:SF9	ENDOTHELIN-2
P00056	VEGF signaling pathway	P01408	Akt/PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01390	TFIIA complex	TAKRU|Ensembl=ENSTRUG00000003740|UniProtKB=H2S8Q9	Transcription initiation factor IIA subunit 2	ISS			PTHR10966:SF0	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2
P00018	EGF receptor signaling pathway	P00545	JNK1-3	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=2445019|UniProtKB=Q6PF93	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00036	Interleukin signaling pathway	P00977	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P02738	De novo purine biosynthesis	P02891	GDP kinase	PSEAE|EnsemblGenome=PA3807|UniProtKB=Q59636	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	TAS	11256888	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00025	Hedgehog signaling pathway	P00692	GSK3	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	BOVIN|Gene=ALDH7A1|UniProtKB=Q2KJC9	Alpha-aminoadipic semialdehyde dehydrogenase	ISS			PTHR43521:SF1	ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CANLF|Ensembl=ENSCAFG00000009036|UniProtKB=E2RT75	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00005	Angiogenesis	P00236	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01227	20S proteasome	ORYSJ|EnsemblGenome=OS06G0167600|UniProtKB=Q5VRG3	Proteasome subunit alpha type-4-2	TAS	12859888	PubMed	PTHR11599:SF13	PROTEASOME SUBUNIT ALPHA TYPE-4
P00019	Endothelin signaling pathway	P00574	Big ET1-4	HUMAN|HGNC=3178|UniProtKB=P14138	Endothelin-3	ISS			PTHR13874:SF11	ENDOTHELIN-3
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00060	Ubiquitin proteasome pathway	P01491	E2	ARATH|TAIR=AT2G32790|UniProtKB=O48838	At2g32790	ISS			PTHR24068:SF74	FI16911P1-RELATED
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=95771|UniProtKB=B2RSH2	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	DROME|FlyBase=FBgn0001991|UniProtKB=Q24270	Voltage-dependent calcium channel type D subunit alpha-1	ISS	8838325	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00034	Integrin signalling pathway	P00916	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	RAT|RGD=2245|UniProtKB=P22002	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	11956331	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P06959	CCKR signaling map	P07067	AP2M1	HUMAN|HGNC=564|UniProtKB=Q96CW1	AP-2 complex subunit mu	RCA	8995203	PubMed	PTHR10529:SF236	AP-2 COMPLEX SUBUNIT MU
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00012	Cadherin signaling pathway	P00474	Wnt	CANLF|Ensembl=ENSCAFG00000008760|UniProtKB=E2RTG8	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00048	PI3 kinase pathway	P01192	p110	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01152	RasGAP	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00005	Angiogenesis	P00181	SHP2	TAKRU|Ensembl=ENSTRUG00000018529|UniProtKB=H2VDZ2	Tyrosine-protein phosphatase non-receptor type	ISS	8096088	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000011532|UniProtKB=F7BZL6	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	HUMAN|HGNC=4385|UniProtKB=P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00001	Adrenaline and noradrenaline biosynthesis	P00061	PNMT	CAEEL|WormBase=WBGene00011573|UniProtKB=Q22279	Amine N-MethylTransferase	ISS			PTHR10867:SF16	AMINE N-METHYLTRANSFERASE
P00015	Circadian clock system	G01500	bmal1	DANRE|ZFIN=ZDB-GENE-000509-1|UniProtKB=Q9I879	Bmal1	ISS			PTHR23042:SF52	ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 1
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00029	Huntington disease	P00774	Dynein complex	PANTR|Ensembl=ENSPTRG00000005536|UniProtKB=H2Q713	Dynein, light chain, LC8-type 1	ISS	9454836	PubMed	PTHR11886:SF52	DYNEIN LIGHT CHAIN 1, CYTOPLASMIC
P00053	T cell activation	P01336	Jnk	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	ORNAN|Ensembl=ENSOANG00000012083|UniProtKB=F7FPY5	Actin-related protein 2/3 complex subunit 4	ISS	5031595	gi	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00047	PDGF signaling pathway	P01161	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P01486	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	15531580	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04384	Gamma-aminobutyric acid synthesis	P04480	GABA aminotransferase	EMENI|EnsemblGenome=CADANIAG00008938|UniProtKB=P14010	4-aminobutyrate aminotransferase	ISS	2505051	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00018	EGF receptor signaling pathway	P00557	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00983	Raf	CHICK|Ensembl=ENSGALG00000004998|UniProtKB=P05625	RAF proto-oncogene serine/threonine-protein kinase	ISS	12843393	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05925	beta-ARR1	RAT|RGD=2156|UniProtKB=P29066	Beta-arrestin-1	RCA	4757780	gi	PTHR11792:SF22	BETA-ARRESTIN-1
P00059	p53 pathway	P04609	PI3K	HUMAN|HGNC=8979|UniProtKB=P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04393	Ras Pathway	P04557	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00006	Apoptosis signaling pathway	P00320	SODD	HUMAN|HGNC=940|UniProtKB=O95429	BAG family molecular chaperone regulator 4	IDA	9915703	PubMed	PTHR12329:SF10	BAG FAMILY MOLECULAR CHAPERONE REGULATOR 4
P00054	Toll receptor signaling pathway	P01355	AP1	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	11840290	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00049	Parkinson disease	P01242	Casein kinase I	MOUSE|MGI=MGI=1934950|UniProtKB=Q8BK63	Casein kinase I isoform alpha	IDA	11437445	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P02763	Peptidoglycan biosynthesis	P03087	Glutamate racemase	LEPIN|EnsemblGenome=LA_3051|UniProtKB=Q8F1S7	Glutamate racemase	ISS			PTHR21198:SF3	SUBFAMILY NOT NAMED
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00752	cGMP-gated ion channel	MOUSE|MGI=MGI=88436|UniProtKB=P29974	cGMP-gated cation channel alpha-1	ISS	12432397	PubMed	PTHR10217:SF387	CYCLIC NUCLEOTIDE-GATED CHANNEL ROD PHOTORECEPTOR SUBUNIT ALPHA
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	BOVIN|Ensembl=ENSBTAG00000033983|UniProtKB=Q0VD16	MAP2K1 protein	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00057	Wnt signaling pathway	P01445	Cerebus	MACMU|Ensembl=ENSMMUG00000012428|UniProtKB=F7DJA6	Cerberus-related protein	ISS	10067895	PubMed	PTHR15273:SF4	CERBERUS
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	HUMAN|HGNC=4574|UniProtKB=P48058	Glutamate receptor 4	ISS	10331083	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00045	Notch signaling pathway	P01101	Su(H)	HUMAN|HGNC=5724|UniProtKB=Q06330	Recombining binding protein suppressor of hairless	ISS	8406481	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P04393	Ras Pathway	P04543	MEKK1/4	MOUSE|MGI=MGI=1346872|UniProtKB=P53349	Mitogen-activated protein kinase kinase kinase 1	IDA	12049732	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00037	Ionotropic glutamate receptor pathway	P01015	Glu4	RAT|RGD=61863|UniProtKB=P19493	Glutamate receptor 4	ISS	12941441	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IGI	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	8132661	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00053	T cell activation	P01303	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	9763606	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00036	Interleukin signaling pathway	P00990	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00018	EGF receptor signaling pathway	P00552	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8313523	PubMed	PTHR24070:SF189	GTPASE NRAS
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00212	EphR	HUMAN|HGNC=3394|UniProtKB=P54753	Ephrin type-B receptor 3	ISS	9990854	PubMed	PTHR24416:SF120	EPHRIN TYPE-B RECEPTOR 3
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	ARATH|TAIR=AT2G18170|UniProtKB=Q39027	Mitogen-activated protein kinase 7	ISS			PTHR24055:SF196	MITOGEN-ACTIVATED PROTEIN KINASE 14-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05913	Enkephalin release	P05977	G-Protein (s)	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00029	Huntington disease	P00801	Fos protein	BOVIN|Ensembl=ENSBTAG00000004322|UniProtKB=O77628	Proto-oncogene c-Fos	TAS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	PSEAE|EnsemblGenome=PA3686|UniProtKB=Q9HXV4	Adenylate kinase	ISS			PTHR23359:SF22	GTP:AMP PHOSPHOTRANSFERASE, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	HUMAN|HGNC=704|UniProtKB=O15143	Actin-related protein 2/3 complex subunit 1B	ISS	12963527	gi	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00034	Integrin signalling pathway	P00920	SOS	PANTR|Ensembl=ENSPTRG00000011857|UniProtKB=H2R8U9	Son of sevenless homolog 1	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	ISS	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	MOUSE|MGI=MGI=101878|UniProtKB=Q9Z121	C-C motif chemokine 8	ISS			PTHR12015:SF144	C-C MOTIF CHEMOKINE 8
P00036	Interleukin signaling pathway	P00965	ERK	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	IC	98269030	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	MONDO|Ensembl=ENSMODG00000019259|UniProtKB=F6Q8Q1	Fructose-bisphosphate aldolase	ISS	2350361	PubMed	PTHR11627:SF3	FRUCTOSE-BISPHOSPHATE ALDOLASE C
P00034	Integrin signalling pathway	P00922	Collagen	HUMAN|HGNC=2187|UniProtKB=P13942	Collagen alpha-2(XI) chain	IDA	10778855	PubMed	PTHR24023:SF509	COLLAGEN ALPHA-2 XI  CHAIN
P00021	FGF signaling pathway	P00629	PP2A	ANOGA|EnsemblGenome=AGAP010172|UniProtKB=Q7PD38	Serine/threonine-protein phosphatase	ISS	1662645	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	HUMAN|HGNC=12647|UniProtKB=Q9BV40	Vesicle-associated membrane protein 8	IC	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00019	Endothelin signaling pathway	P00566	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00807	Actin	SCHPO|PomBase=SPBC32H8.12c|UniProtKB=P10989	Actin	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	P01457	GBeta	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IDA	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00019	Endothelin signaling pathway	P00589	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	IGI	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01332	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01413	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	MYCTU|EnsemblGenome=Rv2992c|UniProtKB=P9WFV9	Glutamate--tRNA ligase	ISS			PTHR43311:SF2	GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED
P00059	p53 pathway	P04626	GADD45	BOVIN|Ensembl=ENSBTAG00000025462|UniProtKB=Q5E9A5	Growth arrest and DNA damage-inducible protein GADD45 beta	ISS	10097101	PubMed	PTHR10411:SF5	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 BETA
P00034	Integrin signalling pathway	P00912	Arp2/3	HUMAN|HGNC=705|UniProtKB=O15144	Actin-related protein 2/3 complex subunit 2	IPI	12473693	PubMed	PTHR12058:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	IDA	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00018	EGF receptor signaling pathway	P00545	JNK1-3	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	EMENI|EnsemblGenome=CADANIAG00007315|UniProtKB=P20359	Actin, gamma	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|RGD=68341|UniProtKB=Q63788	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	7937853	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00021	FGF signaling pathway	P00627	ERK1-2	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	IGI	12787066	PubMed	PTHR24055:SF330	SUBFAMILY NOT NAMED
P00060	Ubiquitin proteasome pathway	P01489	26S proteasome	SCHPO|PomBase=SPBC119.01|UniProtKB=O42897	Probable 26S proteasome regulatory subunit rpn3	ISS	21848401	PubMed	PTHR10758:SF2	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3
P05913	Enkephalin release	P05974	G-Protein (i)	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	1499560	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00019	Endothelin signaling pathway	P00566	ERK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00029	Huntington disease	P00775	Rac	ORYSJ|EnsemblGenome=OS06G0234200|UniProtKB=Q67VP4	Rac-like GTP-binding protein 4	TAS			PTHR24072:SF174	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	MONDO|Ensembl=ENSMODG00000020603|UniProtKB=F6ZBJ4	Uncharacterized protein	ISS	11266476	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	RAT|RGD=1308122|UniProtKB=Q5EAP4	Guanine nucleotide binding protein, alpha 14	ISS	9166716	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	MONDO|Ensembl=ENSMODG00000003587|UniProtKB=F7FPX9	Uncharacterized protein	ISS	11437445	PubMed	PTHR11909:SF182	CASEIN KINASE I ISOFORM DELTA
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00057	Wnt signaling pathway	P01451	Galpha	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IDA	1650351	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	HUMAN|HGNC=233|UniProtKB=Q08462	Adenylate cyclase type 2	ISS	15189569	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00049	Parkinson disease	P01211	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01168	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	EMENI|EnsemblGenome=CADANIAG00007636|UniProtKB=P10874	Tubulin beta-2 chain	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	7597070	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00004	Alzheimer disease-presenilin pathway	P00117	E-cadherin C-terminal fragment	PANTR|Ensembl=ENSPTRG00000008270|UniProtKB=H2QBE5	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF319	CADHERIN-1
P04397	p53 pathway by glucose deprivation	P04641	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	IDA	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00223	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00057	Wnt signaling pathway	P01465	Ggamma	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00053	T cell activation	P01319	PAK	MACMU|Ensembl=ENSMMUG00000001387|UniProtKB=F7D0B4	Uncharacterized protein	ISS	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	IC	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04393	Ras Pathway	P04558	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04374	5HT2 type receptor mediated signaling pathway	P04418	5HT vesicular transporter	PANTR|Ensembl=ENSPTRG00000020039|UniProtKB=H2R9W1	Uncharacterized protein	ISS	92370677	PubMed	PTHR23506:SF15	CHROMAFFIN GRANULE AMINE TRANSPORTER
P06664	Gonadotropin-releasing hormone receptor pathway	P06743	Cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	RCA	12928366	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00046	Oxidative stress response	P01135	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	12810719	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IPI	14526383	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04542	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06850	PKCs(3)	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	RCA	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00256	PLC-gamma	BOVIN|Gene=PLCG1|UniProtKB=P08487	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00018	EGF receptor signaling pathway	P00564	Rac	DROME|FlyBase=FBgn0014011|UniProtKB=P48554	Ras-related protein Rac2	ISS	4757952	gi	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00398	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00019	Endothelin signaling pathway	P00572	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	12876277	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00018	EGF receptor signaling pathway	P00565	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IGI	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=1344366|UniProtKB=E9Q9Q6	Protein Cdh18	ISS	8120095	PubMed	PTHR24027:SF106	CADHERIN-18
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	XENTR|Xenbase=XB-GENE-967585|UniProtKB=Q28BZ0	Cell division cycle 42 (GTP binding protein, 25kDa)	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	PANTR|Ensembl=ENSPTRG00000039733|UniProtKB=H2RDP9	Actin-related protein 2/3 complex subunit 4	ISS	9230079	PubMed	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000005792|UniProtKB=F6VTR8	Uncharacterized protein	ISS	129387	gi	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P00010	B cell activation	P00394	BLNK	HUMAN|HGNC=14211|UniProtKB=Q8WV28	B-cell linker protein	IGI	11274146	PubMed	PTHR14098:SF3	B-CELL LINKER PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00005	Angiogenesis	P00252	Grb2	RAT|RGD=1306884|UniProtKB=Q4KM68	GRB2-related adaptor protein	ISS			PTHR24418:SF282	GRB2-RELATED ADAPTER PROTEIN
P00019	Endothelin signaling pathway	P00566	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	13430383	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00022	General transcription by RNA polymerase I	P00649	TAF-IC	HUMAN|HGNC=11534|UniProtKB=Q15572	TATA box-binding protein-associated factor RNA polymerase I subunit C	IGI	20355009	PubMed	PTHR15319:SF1	TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT C
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12932731	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00010	B cell activation	P00398	IP3R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=12644|UniProtKB=Q15836	Vesicle-associated membrane protein 3	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P06664	Gonadotropin-releasing hormone receptor pathway	G06892	GnRHR	MOUSE|MGI=MGI=95790|UniProtKB=Q01776	Gonadotropin-releasing hormone receptor	RCA	1333052	PubMed	PTHR24241:SF22	GONADOTROPIN-RELEASING HORMONE RECEPTOR
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	15135396	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05730	Endogenous cannabinoid signaling	P05751	Galpha	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00570	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05731	GABA-B receptor II signaling	P05752	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P05731	GABA-B receptor II signaling	P05755	Gbeta	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00010	B cell activation	P00370	NFkappaB	RAT|RGD=1307189|UniProtKB=Q5U2Z4	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	ISS	12574369	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	MOUSE|MGI=MGI=95819|UniProtKB=P35438	Glutamate receptor ionotropic, NMDA 1	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04377	Beta1 adrenergic receptor signaling pathway	P04433	Beta1	BOVIN|Gene=ADRB1|UniProtKB=Q9TT96	Beta-1 adrenergic receptor	ISS	12063255	PubMed	PTHR24248:SF54	BETA-1 ADRENERGIC RECEPTOR
P00019	Endothelin signaling pathway	P00591	PLCbeta	MACMU|Ensembl=ENSMMUG00000020535|UniProtKB=F7D8C0	Phosphoinositide phospholipase C	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	DROME|FlyBase=FBgn0003093|UniProtKB=P13678	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000014674|UniProtKB=P41985	Muscarinic acetylcholine receptor M2	ISS	91373358	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P02731	Biotin biosynthesis	P02859	Dethiobiotin synthase	BACSU|EnsemblGenome=BSU30210|UniProtKB=P53558	ATP-dependent dethiobiotin synthetase BioD	ISS			PTHR43210:SF2	DETHIOBIOTIN SYNTHETASE
P00029	Huntington disease	P00790	beta-Tubulin	ARATH|TAIR=AT1G75780|UniProtKB=P12411	Tubulin beta-1 chain	TAS	9454836	PubMed	PTHR11588:SF116	TUBULIN BETA-1 CHAIN-RELATED
P00018	EGF receptor signaling pathway	P00565	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IGI	22246731	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00019	Endothelin signaling pathway	P00589	Akt	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01129	JNK1/2	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	ISS	2837282	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00012	Cadherin signaling pathway	P00470	F-actin	PHYPA|Gene=PHYPADRAFT_226658|UniProtKB=A9TYG3	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	TAKRU|Ensembl=ENSTRUG00000012732|UniProtKB=H2U5K6	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00006	Apoptosis signaling pathway	P00286	AIF	RAT|RGD=620817|UniProtKB=Q9JM53	Apoptosis-inducing factor 1, mitochondrial	IDA	9989411	PubMed	PTHR43557:SF4	APOPTOSIS-INDUCING FACTOR 1, MITOCHONDRIAL
P06664	Gonadotropin-releasing hormone receptor pathway	P06769	Gbeta	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00005	Angiogenesis	P00243	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01185	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00018	EGF receptor signaling pathway	P00551	Akt	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	CANLF|Ensembl=ENSCAFG00000023687|UniProtKB=F1PCC1	Receptor protein serine/threonine kinase	ISS	9395284	PubMed	PTHR23255:SF63	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-2
P00021	FGF signaling pathway	P00624	14-3-3	HUMAN|HGNC=12849|UniProtKB=P31946	14-3-3 protein beta/alpha	IGI	12618428	PubMed	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00046	Oxidative stress response	P01138	MKK4	MOUSE|MGI=MGI=1346875|UniProtKB=O08648	Mitogen-activated protein kinase kinase kinase 4	TAS	9079650	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00005	Angiogenesis	P00181	SHP2	BOVIN|Ensembl=ENSBTAG00000002048|UniProtKB=F1N339	Tyrosine-protein phosphatase non-receptor type	ISS	14534538	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00036	Interleukin signaling pathway	P00965	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02738	De novo purine biosynthesis	P02895	IMP dehydrogenase	PSEAE|EnsemblGenome=PA3770|UniProtKB=Q9HXM5	Inosine-5'-monophosphate dehydrogenase	ISS			PTHR11911:SF6	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00018	EGF receptor signaling pathway	P00562	p38	HUMAN|HGNC=6876|UniProtKB=Q16539	Mitogen-activated protein kinase 14	IPI	95269808	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04398	p53 pathway feedback loops 2	P04657	P110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	HUMAN|HGNC=9508|UniProtKB=P49768	Presenilin-1	IDA	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00034	Integrin signalling pathway	P00927	Rac	RAT|RGD=619755|UniProtKB=Q6RUV5	Ras-related C3 botulinum toxin substrate 1	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000015240|UniProtKB=F6VUY3	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF26	METABOTROPIC GLUTAMATE RECEPTOR 8
P00018	EGF receptor signaling pathway	P00560	Raf-1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IGI	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01414	PLC-gamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00012	Cadherin signaling pathway	P00470	F-actin	PHANO|EnsemblGenome=SNOG_01139|UniProtKB=H2KNE6	Putative uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	XENTR|Ensembl=ENSXETG00000030140|UniProtKB=F7EP58	Uncharacterized protein (Fragment)	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P05731	GABA-B receptor II signaling	P05752	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00254	GTPase	HUMAN|HGNC=669|UniProtKB=P08134	Rho-related GTP-binding protein RhoC	ISS	12090470	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	DICPU|Gene=DICPUDRAFT_91511|UniProtKB=F0ZDJ1	Serine/threonine-protein phosphatase	ISS	99379588	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00627	ERK1-2	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01430	p53	HUMAN|HGNC=11998|UniProtKB=P04637	Cellular tumor antigen p53	IDA	11313951	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P04393	Ras Pathway	P04542	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00057	Wnt signaling pathway	P01456	beta-arrestin	MACMU|Ensembl=ENSMMUG00000013935|UniProtKB=F6SLP9	Uncharacterized protein	ISS	11742073	PubMed	PTHR11792:SF19	ARRESTIN-C
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00036	Interleukin signaling pathway	P00964	p90RSK	BOVIN|Ensembl=ENSBTAG00000021741|UniProtKB=F1MNR5	Ribosomal protein S6 kinase	ISS	15526037	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00018	EGF receptor signaling pathway	P00558	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00019	Endothelin signaling pathway	P00572	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8388392	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00018	EGF receptor signaling pathway	P00543	ERK1-2	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00052	TGF-beta signaling pathway	P01292	RSmads	DANRE|ZFIN=ZDB-GENE-990603-9|UniProtKB=Q9W7E7	Mothers against decapentaplegic homolog 5	TAS	9395284	PubMed	PTHR13703:SF36	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5
P00036	Interleukin signaling pathway	P00965	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04568	MKK3/6	ORNAN|Ensembl=ENSOANG00000007732|UniProtKB=F6PXH5	Uncharacterized protein (Fragment)	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00045	Notch signaling pathway	P01114	Ntm	PANTR|Ensembl=ENSPTRG00000021561|UniProtKB=H2QY65	Uncharacterized protein	ISS	1764995	PubMed	PTHR43959:SF1	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	BOVIN|Ensembl=ENSBTAG00000011723|UniProtKB=E1BKL6	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00010	B cell activation	P00385	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	8649368	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IDA	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05916	Opioid prodynorphin pathway	P06002	G-protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P02738	De novo purine biosynthesis	P02892	5-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase	METAC|EnsemblGenome=MA_3971|UniProtKB=Q8TJ18	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	YEAST|SGD=S000000112|UniProtKB=P16892	Mitogen-activated protein kinase FUS3	TAS			PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00047	PDGF signaling pathway	P01160	IP3 receptor	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00029	Huntington disease	P00780	Microtubule	STRPU|EnsemblGenome=SPU_002788|UniProtKB=W4XHC0	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00023	General transcription regulation	P00668	TFIIB	MONDO|Ensembl=ENSMODG00000012414|UniProtKB=F6PMC9	Uncharacterized protein	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P00049	Parkinson disease	P01208	Hsp70	SCHPO|PomBase=SPAC22A12.15c|UniProtKB=P36604	78 kDa glucose-regulated protein homolog	IDA	12150907	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00047	PDGF signaling pathway	P01157	MAPKAPK2	CANLF|Ensembl=ENSCAFG00000011432|UniProtKB=F1PZ82	Uncharacterized protein	ISS			PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00059	p53 pathway	G04694	p110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00852	PYK2	PANTR|Ensembl=ENSPTRG00000020104|UniProtKB=H2QVX8	PTK2B protein tyrosine kinase 2 beta	ISS	10753828	PubMed	PTHR24418:SF94	PROTEIN-TYROSINE KINASE 2-BETA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-486685|UniProtKB=F6VT32	Protein kinase C	ISS	11880265	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00053	T cell activation	P01311	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	3491291	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	SCHPO|PomBase=SPBC12D12.04c|UniProtKB=P36583	Protein kinase C-like 2	IGI	93259141	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P02736	Coenzyme A biosynthesis	P02884	Dephospho-CoA kinase	MYCTU|EnsemblGenome=Rv1631|UniProtKB=P9WPA3	Dephospho-CoA kinase	ISS			PTHR10695:SF26	BIFUNCTIONAL COENZYME A SYNTHASE
P00040	Metabotropic glutamate receptor group II pathway	P01048	mGluR2/3	BOVIN|Ensembl=ENSBTAG00000018989|UniProtKB=A5D7D8	GRM3 protein	ISS	9407094	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P04398	p53 pathway feedback loops 2	P04665	AKT	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00005	Angiogenesis	P00254	GTPase	BOVIN|Ensembl=ENSBTAG00000014299|UniProtKB=Q1RMJ6	Rho-related GTP-binding protein RhoC	ISS	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P04371	5-Hydroxytryptamine biosynthesis	P04400	Aromatic L-amino acid decarboxylase	PANTR|Ensembl=ENSPTRG00000019189|UniProtKB=H2QUK8	Uncharacterized protein	ISS	7567987	PubMed	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P02728	Arginine biosynthesis	P02842	N-acetylornithine aminotransferase	MYCTU|EnsemblGenome=Rv1655|UniProtKB=P9WPZ7	Acetylornithine aminotransferase	ISS	10074354	PubMed	PTHR11986:SF79	ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL
P00057	Wnt signaling pathway	P01443	Phospholipase C	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000011461|UniProtKB=P28190	Adenosine receptor A1	ISS	11781138	PubMed	PTHR24246:SF1	ADENOSINE RECEPTOR A1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00010	B cell activation	P00371	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=1306541|UniProtKB=D3ZVF3	Phosphoinositide-3-kinase, class 2, beta polypeptide (Predicted)	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	PANTR|Ensembl=ENSPTRG00000014570|UniProtKB=H2QLZ5	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	DICDI|dictyBase=DDB_G0288319|UniProtKB=O96626	Actin-related protein 2/3 complex subunit 5	ISS	12473693	PubMed	PTHR12644:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	22065540	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	HUMAN|HGNC=9391|UniProtKB=P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	188830	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CHICK|Ensembl=ENSGALG00000004237|UniProtKB=Q5ZM91	cAMP-dependent protein kinase type I-alpha regulatory subunit	IC	176892	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02914	dCDP kinase	CHLTR|EnsemblGenome=CT_500|UniProtKB=O84508	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P02731	Biotin biosynthesis	P02859	Dethiobiotin synthase	STRCO|EnsemblGenome=CAC01470|UniProtKB=Q9FCC1	ATP-dependent dethiobiotin synthetase BioD	ISS			PTHR43210:SF2	DETHIOBIOTIN SYNTHETASE
P00019	Endothelin signaling pathway	P00586	Gq	PANTR|Ensembl=ENSPTRG00000021042|UniProtKB=H2QXD4	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00021	FGF signaling pathway	P00642	MEK1-2	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02740	De novo pyrimidine ribonucleotides biosythesis	P02927	Dihydrooratate oxidase	PANTR|Ensembl=ENSPTRG00000008333|UniProtKB=H2QBH6	Dihydroorotate dehydrogenase (quinone), mitochondrial	ISS			PTHR43517:SF1	DIHYDROOROTATE DEHYDROGENASE  QUINONE , MITOCHONDRIAL
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00256	PLC-gamma	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	90154080	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00036	Interleukin signaling pathway	P00966	mTOR	CHICK|Ensembl=ENSGALG00000003339|UniProtKB=F1NUX4	Uncharacterized protein	ISS	14526383	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00015	Circadian clock system	P00502	Casein kinase I	MOUSE|MGI=MGI=1351660|UniProtKB=Q9JMK2	Casein kinase I isoform epsilon	IDA	11437445	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IDA	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=95776|UniProtKB=P21279	Guanine nucleotide-binding protein G(q) subunit alpha	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04392	P53 pathway feedback loops 1	P04539	p53	MOUSE|MGI=MGI=98834|UniProtKB=P02340	Cellular tumor antigen p53	TAS	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00742	Ca2+channel	MOUSE|MGI=MGI=88296|UniProtKB=O55017	Voltage-dependent N-type calcium channel subunit alpha-1B	IDA	15079861	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00050	Plasminogen activating cascade	P01259	pro-MMP-9	HUMAN|HGNC=7176|UniProtKB=P14780	Matrix metalloproteinase-9	ISS	12834808	PubMed	PTHR10201:SF30	MATRIX METALLOPROTEINASE-9
P00047	PDGF signaling pathway	P01150	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02931	CTP synthase	THEMA|EnsemblGenome=TM_0803|UniProtKB=Q9WZR0	CTP synthase	ISS			PTHR11550:SF0	CTP SYNTHASE
P00011	Blood coagulation	P00415	Plasmin	RAT|RGD=619893|UniProtKB=Q01177	Plasminogen	ISS	15928602	gi	PTHR24261:SF5	PLASMINOGEN
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00644	p38	MOUSE|MGI=MGI=1346864|UniProtKB=Q9Z1B7	Mitogen-activated protein kinase 13	IGI	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P02751	Lysine biosynthesis	P03013	Aspartate semialdehyde dehydrogenase	AQUAE|EnsemblGenome=aq_1866|UniProtKB=O67716	Aspartate-semialdehyde dehydrogenase	ISS			PTHR10174:SF2	ASPARTATE-SEMIALDEHYDE DEHYDROGENASE
P00047	PDGF signaling pathway	P01145	c-fos	BOVIN|Ensembl=ENSBTAG00000004322|UniProtKB=O77628	Proto-oncogene c-Fos	ISS	10411321	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00019	Endothelin signaling pathway	P00591	PLCbeta	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	1333955	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04393	Ras Pathway	P04557	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	XENTR|Xenbase=XB-GENE-486685|UniProtKB=F6VT32	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	ORNAN|Ensembl=ENSOANG00000000972|UniProtKB=F6XL80	Uncharacterized protein	ISS	10839363	PubMed	PTHR19957:SF104	SYNTAXIN-6
P00049	Parkinson disease	P01211	ERK	MACMU|Ensembl=ENSMMUG00000001187|UniProtKB=F6R8N9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00005	Angiogenesis	P00194	Paxillin	RAT|RGD=1305759|UniProtKB=Q66H76	Paxillin	ISS	9182576	PubMed	PTHR24216:SF11	PAXILLIN
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00021	FGF signaling pathway	P00632	Akt	TAKRU|Ensembl=ENSTRUG00000013476|UniProtKB=H2UBP8	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02748	Isoleucine biosynthesis	P02997	Acetolactate synthase	ORYSJ|Gene=Os02g0510200|UniProtKB=Q6K2E8	Acetolactate synthase 1, chloroplastic	ISS			PTHR18968:SF112	ACETOLACTATE SYNTHASE, CHLOROPLASTIC
P04395	Vasopressin synthesis	P04590	Vasopressin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05730	Endogenous cannabinoid signaling	P05746	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IC	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	BOVIN|Ensembl=ENSBTAG00000004775|UniProtKB=F1MBY1	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00051	TCA cycle	P01266	Pyruvate Dehydrogenase	CHLTR|EnsemblGenome=CT_245|UniProtKB=O84247	Pyruvate dehydrogenase E1 component subunit alpha	ISS	9784136	PubMed	PTHR11516:SF53	SUBFAMILY NOT NAMED
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	IC	2303451	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00925	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	DANRE|ZFIN=ZDB-GENE-030616-53|UniProtKB=Q71E60	AMPA receptor subunit GluR3B	ISS	10331083	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02771	Pyrimidine Metabolism	P03128	Dihydrouracil Dehydrogenase	PANTR|Ensembl=ENSPTRG00000000990|UniProtKB=H2PZG2	Dihydropyrimidine dehydrogenase	ISS	8083224	PubMed	PTHR43073:SF2	DIHYDROPYRIMIDINE DEHYDROGENASE  NADP +
P04393	Ras Pathway	P04572	JNK	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00846	JAK	HUMAN|HGNC=6192|UniProtKB=O60674	Tyrosine-protein kinase JAK2	ISS	22482294	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P02738	De novo purine biosynthesis	P02908	Phosphoribosylamine glycine ligase	YARLI|EnsemblGenome=YALI0_F21010g|UniProtKB=Q99148	Bifunctional purine biosynthetic protein ADE1	ISS			PTHR10520:SF10	TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3
P05915	Opioid proenkephalin pathway	P05987	peptide F	DANRE|ZFIN=ZDB-GENE-030729-31|UniProtKB=A8E7S2	Uncharacterized protein	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00018	EGF receptor signaling pathway	P00543	ERK1-2	CAEEL|WormBase=WBGene00003402|UniProtKB=H2KYF8	Mitogen-activated protein kinase	ISS			PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P00056	VEGF signaling pathway	P01414	PLC-gamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	12429574	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	MOUSE|MGI=MGI=97515|UniProtKB=Q04592	Proprotein convertase subtilisin/kexin type 5	IDA			PTHR42884:SF7	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 5
P05731	GABA-B receptor II signaling	P05755	Gbeta	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P05731	GABA-B receptor II signaling	P05754	Ggamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00831	PDK1	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	TAS	14585963	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	2611232	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00932	FAK	BOVIN|Ensembl=ENSBTAG00000005958|UniProtKB=F1N0Z0	Uncharacterized protein	ISS	12640026	PubMed	PTHR24418:SF94	PROTEIN-TYROSINE KINASE 2-BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00089	Pen-2	PANTR|Ensembl=ENSPTRG00000029038|UniProtKB=H2QG41	Presenilin enhancer 2 homolog	ISS	12110170	PubMed	PTHR16318:SF0	GAMMA-SECRETASE SUBUNIT PEN-2
P00053	T cell activation	P01332	Akt	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00021	FGF signaling pathway	P00642	MEK1-2	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P02745	Glutamine glutamate conversion	P04483	Glutamine synthase	AQUAE|EnsemblGenome=aq_111|UniProtKB=O66514	Glutamine synthetase	ISS			PTHR43407:SF1	LENGSIN
P00019	Endothelin signaling pathway	P00568	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IGI	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00644	p38	CANLF|Ensembl=ENSCAFG00000000685|UniProtKB=E2RSB0	Mitogen-activated protein kinase	ISS	8920915	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00057	Wnt signaling pathway	P01465	Ggamma	HUMAN|HGNC=4404|UniProtKB=P59768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	IDA	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00018	EGF receptor signaling pathway	P00562	p38	MACMU|Ensembl=ENSMMUG00000014106|UniProtKB=F7C7A5	Mitogen-activated protein kinase	ISS	8920915	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00021	FGF signaling pathway	P00644	p38	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	IGI	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MACMU|Ensembl=ENSMMUG00000000862|UniProtKB=F6TFY2	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P06216	SCW signaling pathway	P06320	PUT	DROME|Gene=Dmel_CG7904|UniProtKB=A0A0B4KG59	Serine/threonine-protein kinase receptor	IEA	9395284	PubMed	PTHR23255:SF70	SERINE/THREONINE-PROTEIN KINASE RECEPTOR
P00018	EGF receptor signaling pathway	P00564	Rac	HUMAN|HGNC=9801|UniProtKB=P63000	Ras-related C3 botulinum toxin substrate 1	IPI	14564011	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00036	Interleukin signaling pathway	P00996	STAT	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	14984365	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00034	Integrin signalling pathway	P00920	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IPI	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00020	FAS signaling pathway	P00610	MKK4	MONDO|Ensembl=ENSMODG00000008266|UniProtKB=F6Z879	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1707501	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P02749	Leucine biosynthesis	P03000	Branched chain amino acid aminotransferase	MOUSE|MGI=MGI=104861|UniProtKB=P24288	Branched-chain-amino-acid aminotransferase, cytosolic	ISS			PTHR11825:SF51	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, CYTOSOLIC
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	RAT|RGD=628852|UniProtKB=Q02294	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	11976940	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00034	Integrin signalling pathway	P00936	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MOUSE|MGI=MGI=1338024|UniProtKB=Q9WUI1	Mitogen-activated protein kinase 11	IDA	11274345	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P04374	5HT2 type receptor mediated signaling pathway	P04413	K+ channel	RAT|RGD=621451|UniProtKB=Q9ES08	Potassium channel subfamily K member 9	ISS	11875121	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	CHICK|Ensembl=ENSGALG00000004083|UniProtKB=Q90855	AMPA receptor GluR1/A	ISS	12941441	PubMed	PTHR18966:SF157	GLUTAMATE RECEPTOR 1
P00053	T cell activation	P01332	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=708344|UniProtKB=P52287	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	CANLF|Gene=GNRHR|UniProtKB=Q9MZI6	Gonadotropin-releasing hormone receptor	ISS			PTHR24241:SF22	GONADOTROPIN-RELEASING HORMONE RECEPTOR
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	RCA	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00006	Apoptosis signaling pathway	P00260	AKT	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	12657601	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00018	EGF receptor signaling pathway	P00546	GAP	BOVIN|Gene=RASA1|UniProtKB=P09851	Ras GTPase-activating protein 1	IGI	88318957	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04393	Ras Pathway	P04547	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00722	Clathrin	ARATH|TAIR=AT3G11130|UniProtKB=Q0WNJ6	Clathrin heavy chain 1	IDA	9388255	PubMed	PTHR10292:SF1	CLATHRIN HEAVY CHAIN
P02776	Serine glycine biosynthesis	P03160	Phosphoglycerate dehydrogenase	MACMU|Ensembl=ENSMMUG00000023089|UniProtKB=F7DRL6	D-3-phosphoglycerate dehydrogenase	ISS			PTHR42938:SF5	D-3-PHOSPHOGLYCERATE DEHYDROGENASE
P00047	PDGF signaling pathway	P01168	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	91298951	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00005	Angiogenesis	P00219	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00100	C83	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	12707323	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00022	General transcription by RNA polymerase I	P00651	TAF-IA	RAT|RGD=1308423|UniProtKB=D3ZY89	Protein Taf8	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	MACMU|Ensembl=ENSMMUG00000007027|UniProtKB=F7F210	Alpha-cardiac actin	ISS	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P05730	Endogenous cannabinoid signaling	P05743	CB1	MOUSE|MGI=MGI=104615|UniProtKB=P47746	Cannabinoid receptor 1	IGI	9888857	PubMed	PTHR22750:SF47	CANNABINOID RECEPTOR 1
P00057	Wnt signaling pathway	P01459	Casein Kinase 2	ARATH|TAIR=AT4G17640|UniProtKB=P40229	Casein kinase II subunit beta'	IDA	10617630	PubMed	PTHR11740:SF15	CASEIN KINASE II SUBUNIT BETA-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MOUSE|MGI=MGI=107465|UniProtKB=A3KGF7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	12860966	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	HUMAN|HGNC=9993|UniProtKB=O94810	Regulator of G-protein signaling 11	IDA	8756726	PubMed	PTHR10845:SF144	REGULATOR OF G-PROTEIN SIGNALING 11
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00054	Toll receptor signaling pathway	P01360	IKKbeta	PANTR|Ensembl=ENSPTRG00000020202|UniProtKB=H2QW34	Uncharacterized protein	ISS	12075355	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	PANTR|Ensembl=ENSPTRG00000012136|UniProtKB=H2QI95	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00024	Glycolysis	P00679	Aldolase	CANLF|Ensembl=ENSCAFG00000018144|UniProtKB=F1PNI3	Uncharacterized protein	ISS	4812352	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-478663|UniProtKB=F7EG64	Protein kinase C delta type	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00021	FGF signaling pathway	P00627	ERK1-2	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05730	Endogenous cannabinoid signaling	P05746	PLC	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IC	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00029	Huntington disease	P00780	Microtubule	CAEBR|Gene=CBG20196|UniProtKB=A8XX81	Protein CBR-TBB-2	ISS	9454836	PubMed	PTHR11588:SF84	TUBULIN BETA-2 CHAIN
P00023	General transcription regulation	P00658	TBP-associated factors	MOUSE|MGI=MGI=1926879|UniProtKB=Q9EQH4	Transcription initiation factor TFIID subunit 8	ISS	604904	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P04393	Ras Pathway	P04572	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	IDA	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IDA	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00006	Apoptosis signaling pathway	P00321	HSP70	MONDO|Ensembl=ENSMODG00000019764|UniProtKB=F6WMM9	Uncharacterized protein	ISS	10934466	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-030131-7595|UniProtKB=Q6PBR4	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00005	Angiogenesis	P00223	Akt	BOVIN|Ensembl=ENSBTAG00000017788|UniProtKB=F1MYJ4	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04395	Vasopressin synthesis	P04590	Vasopressin	PANTR|Ensembl=ENSPTRG00000013190|UniProtKB=H2QJV2	Uncharacterized protein	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00058	mRNA splicing	P01479	U1	MOUSE|MGI=MGI=1855690|UniProtKB=Q62189	U1 small nuclear ribonucleoprotein A	RCA			PTHR10501:SF31	U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00029	Huntington disease	P00807	Actin	DANRE|ZFIN=ZDB-GENE-000322-1|UniProtKB=Q9I8V1	Actin, alpha 1, skeletal muscle	IDA	11889139	PubMed	PTHR11937:SF184	ACTIN, ALPHA 1, SKELETAL MUSCLE
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IGI	15572354	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	XENTR|Ensembl=ENSXETG00000030140|UniProtKB=F7EP58	Uncharacterized protein (Fragment)	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00020	FAS signaling pathway	P00609	FAF1	MACMU|Ensembl=ENSMMUG00000019056|UniProtKB=F6QTP7	FAS-associated factor 1	ISS	8524870	PubMed	PTHR23322:SF52	FAS-ASSOCIATED FACTOR 1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00885	INSR IGF-R IRR	CANLF|Ensembl=ENSCAFG00000018170|UniProtKB=E2RPM8	Tyrosine-protein kinase receptor	ISS	249616	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00029	Huntington disease	P00799	JNK-2	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00047	PDGF signaling pathway	P01162	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00010	B cell activation	P00371	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	BOVIN|Ensembl=ENSBTAG00000012919|UniProtKB=F1MHG1	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF25	MATRIX METALLOPROTEINASE-15
P02745	Glutamine glutamate conversion	P02968	Glutamine synthetase	CHLRE|EnsemblGenome=CHLREDRAFT_129468|UniProtKB=A8IVZ9	Glutamine synthetase	ISS			PTHR20852:SF57	GLUTAMINE SYNTHETASE 2 CYTOPLASMIC
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2742|UniProtKB=P23385	Metabotropic glutamate receptor 1	IDA			PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00021	FGF signaling pathway	P00643	Raf-1	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IGI	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	MONBE|Gene=11217|UniProtKB=A9V8J8	Predicted protein	ISS	10487978	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00056	VEGF signaling pathway	P01410	Caspase9	PANTR|Ensembl=ENSPTRG00000000200|UniProtKB=H2PY35	Caspase	ISS	8663294	PubMed	PTHR10454:SF157	CASPASE-9
P00057	Wnt signaling pathway	P01451	Galpha	MACMU|Ensembl=ENSMMUG00000021916|UniProtKB=F6T573	Guanine nucleotide-binding protein G(Q) subunit alpha	ISS	1650351	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05730	Endogenous cannabinoid signaling	P05746	PLC	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00029	Huntington disease	P00807	Actin	PANTR|Ensembl=ENSPTRG00000009762|UniProtKB=H2QE24	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P02745	Glutamine glutamate conversion	P02967	Glutamate Dehydrogenase	HUMAN|HGNC=4335|UniProtKB=P00367	Glutamate dehydrogenase 1, mitochondrial	ISS			PTHR11606:SF25	GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL
P00011	Blood coagulation	P00445	FXa	MACMU|Ensembl=ENSMMUG00000001038|UniProtKB=F6SHG6	Uncharacterized protein	ISS	4503625	gi	PTHR44064:SF3	COAGULATION FACTOR X
P05912	Dopamine receptor mediated signaling pathway	P05966	EPB41	PANTR|Ensembl=ENSPTRG00000018597|UniProtKB=H2QTQ8	Erythrocyte membrane protein band 4.1-like 2	ISS	12181426	PubMed	PTHR23280:SF17	BAND 4.1-LIKE PROTEIN 2
P00037	Ionotropic glutamate receptor pathway	P01006	NR2C	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS			PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	TAKRU|Ensembl=ENSTRUG00000008313|UniProtKB=H2T813	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00044	Nicotinic acetylcholine receptor signaling pathway	P01093	AChE	PANTR|Ensembl=ENSPTRG00000015593|UniProtKB=H2QNP1	Carboxylic ester hydrolase	ISS	87080761	PubMed	PTHR43918:SF5	CHOLINESTERASE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	PANTR|Ensembl=ENSPTRG00000012501|UniProtKB=P61072	C-X-C chemokine receptor type 4	ISS	11943720	PubMed	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P00020	FAS signaling pathway	P00615	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00012	Cadherin signaling pathway	P00474	Wnt	MOUSE|MGI=MGI=1261834|UniProtKB=O70283	Protein Wnt-2b	IDA	12549854	PubMed	PTHR12027:SF93	PROTEIN WNT-2B
P00021	FGF signaling pathway	P00648	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IGI	10747026	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00056	VEGF signaling pathway	P01423	p38MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00557	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00215	Nck	CANLF|Ensembl=ENSCAFG00000007451|UniProtKB=E2RHV6	Uncharacterized protein	ISS	12874226	PubMed	PTHR44108:SF2	CYTOPLASMIC PROTEIN NCK1
P00049	Parkinson disease	P01227	20S proteasome	DROME|FlyBase=FBgn0029812|UniProtKB=Q9W470	Proteasome subunit beta type	TAS	12859888	PubMed	PTHR11599:SF44	AT05866P-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00030	Hypoxia response via HIF activation	P00823	PI3K	MOUSE|MGI=MGI=2685045|UniProtKB=E9QAN8	Protein Pik3c2b	ISS	14526383	PubMed	PTHR10048:SF30	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA
P04393	Ras Pathway	P04548	ATF2	PANTR|Ensembl=ENSPTRG00000012660|UniProtKB=H2QJ07	Activating transcription factor 2	ISS	10664585	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00059	p53 pathway	P04616	PDK1/2	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	TAS	9368760	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00056	VEGF signaling pathway	P01407	Erk	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	92205337	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00779	TBP	ARATH|TAIR=AT1G55520|UniProtKB=P28148	TATA-box-binding protein 2	IPI	11988536	PubMed	PTHR10126:SF36	TATA-BOX-BINDING PROTEIN 1-RELATED
P00059	p53 pathway	P04609	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MOUSE|MGI=MGI=95690|UniProtKB=P43029	Growth/differentiation factor 7	TAS	9759503	PubMed	PTHR11848:SF160	GROWTH/DIFFERENTIATION FACTOR 7
P04393	Ras Pathway	P04544	Grb2	RAT|RGD=619758|UniProtKB=P62994	Growth factor receptor-bound protein 2	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00036	Interleukin signaling pathway	P00970	Interleukin	MACMU|Gene=IL6|UniProtKB=P51494	Interleukin-6	ISS			PTHR45110:SF1	INTERLEUKIN-6
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00046	Oxidative stress response	P01129	JNK1/2	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000019573|UniProtKB=H2R358	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000017633|UniProtKB=H2QS62	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	PANTR|Ensembl=ENSPTRG00000000843|UniProtKB=H2QZN8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00053	T cell activation	P01294	NFAT	PANTR|Ensembl=ENSPTRG00000008260|UniProtKB=H2QBD7	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	ISS	9462517	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000009087|UniProtKB=Q3SZ98	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	RCA	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P05916	Opioid prodynorphin pathway	P06001	AC	BOVIN|Gene=ADCY7|UniProtKB=Q29450	Adenylate cyclase type 7	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00048	PI3 kinase pathway	P01178	Grb2	DANRE|ZFIN=ZDB-GENE-040426-1975|UniProtKB=Q6PC73	Growth factor receptor-bound protein 2	ISS	http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd	Website	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-956713|UniProtKB=Q5XGD8	Guanine nucleotide binding protein, beta 3	ISS	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00019	Endothelin signaling pathway	P00587	Raf-1	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS			PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00049	Parkinson disease	P01236	Casein kinase II	DROME|FlyBase=FBgn0000259|UniProtKB=P08182	Casein kinase II subunit beta	IDA	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00019	Endothelin signaling pathway	P00577	PI3K	BOVIN|Gene=PIK3R3|UniProtKB=O46404	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	1171954	gi	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00859	NFkappaB	CANLF|Ensembl=ENSCAFG00000004597|UniProtKB=F1PJ94	Uncharacterized protein	RCA			PTHR24169:SF18	TRANSCRIPTION FACTOR RELB
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	TAS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04393	Ras Pathway	P04552	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IDA	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P05731	GABA-B receptor II signaling	P05755	Gbeta	ORNAN|Ensembl=ENSOANG00000004695|UniProtKB=F7E427	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MACMU|Ensembl=ENSMMUG00000009679|UniProtKB=F6YBQ8	Uncharacterized protein	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BRAFL|Gene=BRAFLDRAFT_60743|UniProtKB=C3XYD4	Putative uncharacterized protein	ISS			PTHR11937:SF350	ACTIN-LIKE PROTEIN ARP10
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	MOUSE|MGI=MGI=88397|UniProtKB=Q9ERZ4	Muscarinic acetylcholine receptor M2	TAS	8100450	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00056	VEGF signaling pathway	P01407	Erk	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CANLF|Ensembl=ENSCAFG00000004275|UniProtKB=F1PJE5	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00003	Alzheimer disease-amyloid secretase pathway	P00081	Pro-BACE-1	MOUSE|MGI=MGI=1346542|UniProtKB=P56818	Beta-secretase 1	IDA	10531052	PubMed	PTHR13683:SF245	BETA-SECRETASE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	IC	15737619	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00020	FAS signaling pathway	P00612	Fas	HUMAN|HGNC=11920|UniProtKB=P25445	Tumor necrosis factor receptor superfamily member 6	TAS	10327065	PubMed	PTHR23097:SF114	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00057	Wnt signaling pathway	P01440	Cadherin	HUMAN|HGNC=1749|UniProtKB=Q9Y6N8	Cadherin-10	IDA	8120095	PubMed	PTHR24027:SF290	CADHERIN-10
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00703	Rap1	DANRE|ZFIN=ZDB-GENE-030131-9662|UniProtKB=Q6TEN1	Ras-related protein Rap-1b	ISS	10476970	PubMed	PTHR24070:SF382	RAS-RELATED PROTEIN RAP-1B
P00005	Angiogenesis	P00215	Nck	MONDO|Ensembl=ENSMODG00000002546|UniProtKB=F7ALW1	Uncharacterized protein	ISS	12874226	PubMed	PTHR44108:SF1	CYTOPLASMIC PROTEIN NCK2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00004	Alzheimer disease-presenilin pathway	P00115	Nicastrin	CANLF|Ensembl=ENSCAFG00000012557|UniProtKB=F1PU73	Uncharacterized protein	ISS	10993067	PubMed	PTHR21092:SF0	NICASTRIN
P05915	Opioid proenkephalin pathway	P05993	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00053	T cell activation	P01319	PAK	CANLF|Ensembl=ENSCAFG00000004956|UniProtKB=E2REH3	Uncharacterized protein	ISS	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MOUSE|MGI=MGI=102704|UniProtKB=P63216	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00022	General transcription by RNA polymerase I	P00652	RNA Polymerase I  Complex	CHICK|Ensembl=ENSGALG00000019444|UniProtKB=E1BW79	Uncharacterized protein	ISS	12634356	PubMed	PTHR12056:SF2	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC4
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	DAPPU|EnsemblGenome=DAPPUDRAFT_59367|UniProtKB=E9H7Z0	Guanine nucleotide-binding protein G(O) subunit alpha 1	ISS	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01163	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	12972619	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00590	IP3 R	MACMU|Ensembl=ENSMMUG00000023128|UniProtKB=F7A818	Uncharacterized protein	ISS	12198155	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	94230340	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS	11313908	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00018	EGF receptor signaling pathway	P00564	Rac	MACMU|Ensembl=ENSMMUG00000018854|UniProtKB=F6XSJ9	Ras-related C3 botulinum toxin substrate 2	ISS	8649368	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	IGI	3755548	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00006	Apoptosis signaling pathway	P00305	Caspase 3	CANLF|Ensembl=ENSCAFG00000007750|UniProtKB=Q8MKI5	Caspase-3	ISS	9323209	PubMed	PTHR10454:SF198	CASPASE-3
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00015	Circadian clock system	G01504	bmal1	PANTR|Ensembl=ENSPTRG00000003376|UniProtKB=H2R2H7	Uncharacterized protein	ISS	11163178	PubMed	PTHR23042:SF52	ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 1
P00005	Angiogenesis	P00236	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00059	p53 pathway	G04690	PAG608	PANTR|Ensembl=ENSPTRG00000015641|UniProtKB=H2QNS0	Uncharacterized protein	ISS			PTHR23067:SF5	ZINC FINGER MATRIN-TYPE PROTEIN 3
P00029	Huntington disease	P00780	Microtubule	TAKRU|Ensembl=ENSTRUG00000005446|UniProtKB=H2SKZ5	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF138	TUBULIN BETA-2B CHAIN
P04398	p53 pathway feedback loops 2	G04714	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	CHICK|Ensembl=ENSGALG00000015434|UniProtKB=F1NU20	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P02775	Salvage pyrimidine ribonucleotides	P03156	CDP kinase	ORYSJ|EnsemblGenome=OS02G0708200|UniProtKB=Q6YV21	Os02g0708200 protein	ISS			PTHR10285:SF122	URIDINE-CYTIDINE KINASE C
P00021	FGF signaling pathway	P00641	SOS	HUMAN|HGNC=11188|UniProtKB=Q07890	Son of sevenless homolog 2	IGI	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P02747	Histidine biosynthesis	P02986	Phosphoribosyl ATP pyrophosphatase	BACSU|EnsemblGenome=BSU34860|UniProtKB=O34912	Histidine biosynthesis bifunctional protein HisIE	ISS			PTHR42945:SF1	HISTIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN HISIE, CHLOROPLASTIC
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	PANTR|Ensembl=ENSPTRG00000014751|UniProtKB=H2R8D8	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF80	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Ensembl=ENSPTRG00000004233|UniProtKB=H2Q4N9	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P04393	Ras Pathway	P04557	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IDA	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-968597|UniProtKB=A4IGZ2	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00034	Integrin signalling pathway	P00913	Csk	MACMU|Ensembl=ENSMMUG00000015267|UniProtKB=F7GRP2	Tyrosine-protein kinase	ISS	7687537	PubMed	PTHR24418:SF307	TYROSINE-PROTEIN KINASE CSK
P00048	PI3 kinase pathway	P01179	PKB	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01446	Calcineurin	EMENI|EnsemblGenome=CADANIAG00006237|UniProtKB=P48457	Serine/threonine-protein phosphatase 2B catalytic subunit	IDA	12015605	PubMed	PTHR11668:SF118	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED
P00036	Interleukin signaling pathway	P00990	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	MONDO|Ensembl=ENSMODG00000014746|UniProtKB=F6YN64	Uncharacterized protein (Fragment)	ISS	12941441	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00047	PDGF signaling pathway	P01151	PKB	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00046	Oxidative stress response	P01123	Bcl-2	MOUSE|MGI=MGI=88138|UniProtKB=P10417	Apoptosis regulator Bcl-2	ISS	2250705	PubMed	PTHR11256:SF11	APOPTOSIS REGULATOR BCL-2
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00047	PDGF signaling pathway	P01174	Rho	CAEEL|WormBase=WBGene00008006|UniProtKB=P46941	WW domain-containing protein tag-325	ISS	8288572	PubMed	PTHR23181:SF10	RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E
P00056	VEGF signaling pathway	P01417	Raf	MOUSE|MGI=MGI=88065|UniProtKB=P04627	Serine/threonine-protein kinase A-Raf	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00006	Apoptosis signaling pathway	P00291	MEKK1	BOVIN|Ensembl=ENSBTAG00000013790|UniProtKB=E1B847	Uncharacterized protein	ISS	12168099	PubMed	PTHR24361:SF414	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	IGI	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05927	Gqalpha	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	HUMAN|HGNC=4584|UniProtKB=Q05586	Glutamate receptor ionotropic, NMDA 1	IC	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00010	B cell activation	P00373	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01451	Galpha	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00006	Apoptosis signaling pathway	P00284	Flip	HUMAN|HGNC=1876|UniProtKB=O15519	CASP8 and FADD-like apoptosis regulator	IDA	9217161	PubMed	PTHR10454:SF8	CASP8 AND FADD-LIKE APOPTOSIS REGULATOR
P00006	Apoptosis signaling pathway	P00274	JNK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MONDO|Ensembl=ENSMODG00000017116|UniProtKB=F6UJE8	Uncharacterized protein	ISS	15521358	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	MACMU|Ensembl=ENSMMUG00000022960|UniProtKB=F6U6I0	Uncharacterized protein	ISS	11960641	PubMed	PTHR10489:SF637	CX3C CHEMOKINE RECEPTOR 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MOUSE|MGI=MGI=87905|UniProtKB=P68033	Actin, alpha cardiac muscle 1	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00047	PDGF signaling pathway	P01143	ERK	DICDI|dictyBase=DDB_G0283903|UniProtKB=Q54QB1	Extracellular signal-regulated kinase 2	ISS	gi:1362216	gi	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00021	FGF signaling pathway	P00623	FGF	MACMU|Ensembl=ENSMMUG00000011744|UniProtKB=F7GWY6	Fibroblast growth factor	ISS	12619867	PubMed	PTHR11486:SF27	FIBROBLAST GROWTH FACTOR 16
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IDA	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	CAEBR|Gene=CBG_05938|UniProtKB=H8WGV2	Protein CBR-ITR-1, isoform a	ISS	4262086	gi	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P00053	T cell activation	P01303	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	12162872	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00017	DNA replication	P00527	Histones	BOVIN|Ensembl=ENSBTAG00000032452|UniProtKB=P84227	Histone H3.2	ISS	12413958	PubMed	PTHR11426:SF161	HISTONE H3.2-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	RCA	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P04393	Ras Pathway	P04542	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CANLF|Gene=HTR2C|UniProtKB=Q60F97	5-hydroxytryptamine receptor 2C	ISS			PTHR24247:SF32	5-HYDROXYTRYPTAMINE RECEPTOR 2C
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00747	Rhodopsin	TAKRU|Ensembl=ENSTRUG00000004527|UniProtKB=Q9IAH8	Rhodopsin	IDA	1634520	PubMed	PTHR24240:SF15	RHODOPSIN
P00010	B cell activation	P00376	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	MOUSE|MGI=MGI=95820|UniProtKB=P35436	Glutamate receptor ionotropic, NMDA 2A	IC	11554549	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P05912	Dopamine receptor mediated signaling pathway	P05948	D1/D5	MOUSE|MGI=MGI=94927|UniProtKB=Q8BLD9	D(1B) dopamine receptor	ISS	15328036	PubMed	PTHR43893:SF8	D 1B  DOPAMINE RECEPTOR
P00056	VEGF signaling pathway	P01417	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00036	Interleukin signaling pathway	P00965	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	10664585	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P05730	Endogenous cannabinoid signaling	P05748	mGluR	HUMAN|HGNC=4597|UniProtKB=P41594	Metabotropic glutamate receptor 5	ISS	8314195	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P06959	CCKR signaling map	P07125	CRK	HUMAN|HGNC=2362|UniProtKB=P46108	Adapter molecule crk	RCA		PubMed	PTHR19969:SF8	ADAPTER MOLECULE CRK
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	DANRE|ZFIN=ZDB-GENE-050417-267|UniProtKB=F1QUN8	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF263	ACTIN
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00168	E-cadherin intracellular fragment	HUMAN|HGNC=1748|UniProtKB=P12830	Cadherin-1	IDA	12834808	PubMed	PTHR24027:SF319	CADHERIN-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	PLAF7|EnsemblGenome=PFB0480w|UniProtKB=O96189	Qa-SNARE protein	IC			PTHR19957:SF41	SYNTAXIN-1A
P00059	p53 pathway	P04633	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01211	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	14698601	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	ORNAN|Ensembl=ENSOANG00000008416|UniProtKB=F6VVA6	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	SCLS1|EnsemblGenome=SS1G_03482|UniProtKB=A7EDU2	Guanine nucleotide-binding protein beta subunit	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00057	Wnt signaling pathway	P01434	sFRP	MOUSE|MGI=MGI=108078|UniProtKB=P97299	Secreted frizzled-related protein 2	ISS	9096311	PubMed	PTHR11309:SF45	SECRETED FRIZZLED-RELATED PROTEIN 2
P04395	Vasopressin synthesis	P04590	Vasopressin	RAT|RGD=2184|UniProtKB=P01186	Vasopressin-neurophysin 2-copeptin	ISS	192340	OMIM	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	CANLF|Ensembl=ENSCAFG00000015662|UniProtKB=E2RHY4	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00005	Angiogenesis	P00253	Axin	MACMU|Ensembl=ENSMMUG00000000605|UniProtKB=F6Y8V8	Uncharacterized protein	ISS	12549854	PubMed	PTHR10845:SF11	AXIN-1
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00717	Phosphorylase b	MOUSE|MGI=MGI=97828|UniProtKB=Q8CI94	Glycogen phosphorylase, brain form	ISS	4318782	PubMed	PTHR11468:SF1	GLYCOGEN PHOSPHORYLASE, BRAIN FORM
P00034	Integrin signalling pathway	P00948	Rho	HUMAN|HGNC=18315|UniProtKB=P52198	Rho-related GTP-binding protein RhoN	IGI	11973360	PubMed	PTHR24072:SF21	RHO-RELATED GTP-BINDING PROTEIN RHON
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MONDO|Ensembl=ENSMODG00000004422|UniProtKB=F6SCX2	Uncharacterized protein	ISS	10938134	PubMed	PTHR13140:SF344	MYOSIN-7
P00036	Interleukin signaling pathway	P00983	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	PANTR|Ensembl=ENSPTRG00000006631|UniProtKB=H2Q8S3	Ribosomal protein S6 kinase	ISS	6755374	gi	PTHR24351:SF115	RIBOSOMAL PROTEIN S6 KINASE ALPHA-5
P00019	Endothelin signaling pathway	P00570	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	ISS	176910	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	BRAFL|Gene=BRAFLDRAFT_87235|UniProtKB=C3ZEV9	Putative uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00020	FAS signaling pathway	P00600	PARP	CAEEL|WormBase=WBGene00004049|UniProtKB=Q9N4H4	Poly(ADP-ribose) polymerase pme-1	TAS	12101391	PubMed	PTHR10459:SF80	POLY  ADP-RIBOSE  POLYMERASE 1
P00059	p53 pathway	P01486	Akt	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00005	Angiogenesis	P00194	Paxillin	MACMU|Ensembl=ENSMMUG00000011713|UniProtKB=F7HC66	Leupaxin isoform 2	ISS			PTHR24216:SF23	LEUPAXIN
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00005	Angiogenesis	P00203	Erk	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	MYCTU|EnsemblGenome=Rv0500|UniProtKB=P9WHU7	Pyrroline-5-carboxylate reductase	ISS			PTHR11645:SF0	PYRROLINE-5-CARBOXYLATE REDUCTASE
P00034	Integrin signalling pathway	P00951	Jnk	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04398	p53 pathway feedback loops 2	P04657	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00210	eNOS	RAT|RGD=3186|UniProtKB=Q62600	Nitric oxide synthase, endothelial	ISS	22462730	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P00005	Angiogenesis	P00195	APC	BOVIN|Ensembl=ENSBTAG00000018852|UniProtKB=F1MV51	Uncharacterized protein	ISS	8259518	PubMed	PTHR12607:SF11	ADENOMATOUS POLYPOSIS COLI PROTEIN
P04393	Ras Pathway	P04579	Shc	RAT|RGD=620446|UniProtKB=Q5M824	SHC-transforming protein 1	ISS	10982827	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00041	Metabotropic glutamate receptor group I pathway	P01060	NMDA	RAT|RGD=2736|UniProtKB=P35439	Glutamate receptor ionotropic, NMDA 1	ISS	14698601	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=2520|UniProtKB=P61169	D(2) dopamine receptor	IDA	11248120	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00731	RGS	PANTR|Ensembl=ENSPTRG00000002161|UniProtKB=H2Q8J8	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF26	REGULATOR OF G-PROTEIN SIGNALING 7
P02772	Pyruvate metabolism	P03141	Citrate Synthetase	HUMAN|HGNC=2422|UniProtKB=O75390	Citrate synthase, mitochondrial	TAS	2337600	PubMed	PTHR11739:SF8	CITRATE SYNTHASE, MITOCHONDRIAL
P00019	Endothelin signaling pathway	P00587	Raf-1	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00990	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	ORNAN|Ensembl=ENSOANG00000004982|UniProtKB=F7DIA9	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF34	FRIZZLED-2
P00036	Interleukin signaling pathway	P00970	Interleukin	MACMU|Ensembl=ENSMMUG00000021093|UniProtKB=P68291	Interleukin-2	ISS	7561102	PubMed	PTHR45426:SF1	INTERLEUKIN-2
P00021	FGF signaling pathway	P00648	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02743	Formyltetrahydroformate biosynthesis	P02954	Thymidylate synthase	SCHPO|PomBase=SPAC15E1.04|UniProtKB=Q9UTI7	Probable thymidylate synthase	ISS			PTHR11548:SF2	THYMIDYLATE SYNTHASE
P05918	p38 MAPK pathway	P06029	p38beta	HUMAN|HGNC=6873|UniProtKB=Q15759	Mitogen-activated protein kinase 11	RCA	10514528	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	XENTR|Xenbase=XB-GENE-942094|UniProtKB=F7A472	Uncharacterized protein (Fragment)	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P05912	Dopamine receptor mediated signaling pathway	P05959	FLNA	CANLF|Ensembl=ENSCAFG00000019521|UniProtKB=F1PWW0	Uncharacterized protein	ISS	9722563	PubMed	PTHR43998:SF6	FILAMIN-A
P00006	Apoptosis signaling pathway	P00260	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00036	Interleukin signaling pathway	P00990	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00629	PP2A	MOUSE|MGI=MGI=2388481|UniProtKB=Q91V89	Protein Ppp2r5d	ISS	10092233	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00052	TGF-beta signaling pathway	P01286	TGFbeta	RAT|RGD=2677|UniProtKB=Q07731	Glial cell line-derived neurotrophic factor	ISS	9759503	PubMed	PTHR12173:SF1	GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	HUMAN|HGNC=9855|UniProtKB=P62834	Ras-related protein Rap-1A	IDA	1904317	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00021	FGF signaling pathway	P00638	PLCgamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00004	Alzheimer disease-presenilin pathway	P00126	Fe65	PANTR|Ensembl=ENSPTRG00000016008|UniProtKB=H2R0S0	Uncharacterized protein	ISS			PTHR14058:SF11	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 2
P04396	Vitamin D metabolism and pathway	P04602	RXR	HUMAN|HGNC=9864|UniProtKB=P10276	Retinoic acid receptor alpha	TAS			PTHR24082:SF115	RETINOIC ACID RECEPTOR ALPHA
P00057	Wnt signaling pathway	P01440	Cadherin	MACMU|Ensembl=ENSMMUG00000014579|UniProtKB=F7GRK8	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF55	PROTOCADHERIN BETA-4
P00029	Huntington disease	P00779	TBP	METJA|EnsemblGenome=MJ_0507|UniProtKB=Q57930	TATA-box-binding protein	IPI	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P02775	Salvage pyrimidine ribonucleotides	P03151	Uracil phosphoribosyl  transferase	SYNY3|EnsemblGenome=BAA16768|UniProtKB=P72753	Uracil phosphoribosyltransferase	ISS			PTHR10285:SF46	URACIL PHOSPHORIBOSYLTRANSFERASE, CHLOROPLASTIC
P00005	Angiogenesis	P00209	FAK	HUMAN|HGNC=9611|UniProtKB=Q05397	Focal adhesion kinase 1	IDA	9182576	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00005	Angiogenesis	P00221	JNK1	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	11707292	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8977|UniProtKB=O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CHICK|Ensembl=ENSGALG00000002016|UniProtKB=F1P3G1	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00022	General transcription by RNA polymerase I	P00657	TBP	ENTHI|Gene=EHI_112050|UniProtKB=C4M7H7	TATA-box-binding protein 2	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	HUMAN|HGNC=9410|UniProtKB=Q04759	Protein kinase C theta type	ISS	3045562	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000014132|UniProtKB=F7C1A7	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	TAS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00871	IKK	BOVIN|Ensembl=ENSBTAG00000007599|UniProtKB=Q95KV0	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P02738	De novo purine biosynthesis	P02889	dGDP kinase	ANOGA|EnsemblGenome=AGAP007120|UniProtKB=Q7QIX6	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P02727	Androgen/estrogene/progesterone biosynthesis	P02829	Cholesterol acyltransferase	PANTR|Ensembl=ENSPTRG00000001728|UniProtKB=H2Q0P3	O-acyltransferase	ISS	11948213	PubMed	PTHR10408:SF6	STEROL O-ACYLTRANSFERASE 1
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000001187|UniProtKB=F6R8N9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	CANLF|Ensembl=ENSCAFG00000017516|UniProtKB=E2REK6	Uncharacterized protein	ISS	7514101	PubMed	PTHR23050:SF311	CALMODULIN
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00057	Wnt signaling pathway	P01451	Galpha	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	IC	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00021	FGF signaling pathway	P00628	JNK1-3	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00021	FGF signaling pathway	P00627	ERK1-2	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00545	JNK1-3	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00045	Notch signaling pathway	P01099	Notch	CANLF|Ensembl=ENSCAFG00000010476|UniProtKB=F1PS94	Uncharacterized protein	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00021	FGF signaling pathway	P00638	PLCgamma	MONDO|Ensembl=ENSMODG00000000626|UniProtKB=F6TAH0	Phosphoinositide phospholipase C (Fragment)	ISS	12437926	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04393	Ras Pathway	P04572	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=1921305|UniProtKB=Q8K4S1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	7822322	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00047	PDGF signaling pathway	P01154	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00060	Ubiquitin proteasome pathway	P01492	E1	XENTR|Xenbase=XB-GENE-947291|UniProtKB=F6VFZ5	Uncharacterized protein	ISS			PTHR10953:SF6	NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	ARATH|TAIR=AT3G54490|UniProtKB=Q9M1H8	DNA-directed RNA polymerase V subunit 5C	ISS	11313498	PubMed	PTHR10535:SF6	DNA-DIRECTED RNA POLYMERASE V SUBUNIT 5C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00876	Arp2/3	DICDI|dictyBase=DDB_G0277825|UniProtKB=O96622	Actin-related protein 2/3 complex subunit 1	ISS	12932731	PubMed	PTHR10709:SF2	ACTIN RELATED COMPLEX P41 SUBUNIT
P04393	Ras Pathway	P04567	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	7937853	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00019	Endothelin signaling pathway	P00584	Gs	SCHMA|EnsemblGenome=Smp_059340|UniProtKB=C4QDC7	Guanine nucleotide-binding protein G(S) subunit alpha (Adenylate cyclase-stimulating G alpha protein),putative	ISS	14765990	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00046	Oxidative stress response	P01135	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	TAS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00034	Integrin signalling pathway	P00947	Laminin	MONDO|Ensembl=ENSMODG00000016246|UniProtKB=F7A5M5	Uncharacterized protein (Fragment)	ISS	2538453	PubMed	PTHR10574:SF233	LAMININ SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00565	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	12857744	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00164	Nectin 1alpha N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000015939|UniProtKB=F1MQJ3	Uncharacterized protein	ISS	12376527	PubMed	PTHR23277:SF69	NECTIN-1
P00010	B cell activation	P00384	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	TAKRU|Ensembl=ENSTRUG00000016369|UniProtKB=H2UY24	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P05918	p38 MAPK pathway	P06035	TAB1	HUMAN|HGNC=18157|UniProtKB=Q15750	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1	RCA	8638164	PubMed	PTHR13832:SF533	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1
P00060	Ubiquitin proteasome pathway	P01491	E2	MACMU|Ensembl=ENSMMUG00000020666|UniProtKB=F7BEK3	Uncharacterized protein	ISS			PTHR24068:SF40	UBIQUITIN-CONJUGATING ENZYME E2 D2-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=620231|UniProtKB=O70173	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	ISS	7937853	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=7578|UniProtKB=P13535	Myosin-8	IC	10938134	PubMed	PTHR13140:SF368	MYOSIN-8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	XENTR|Xenbase=XB-GENE-491618|UniProtKB=Q6P378	Actin, cytoplasmic 2	ISS	3487386	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P00021	FGF signaling pathway	P00632	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	IGI	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=1563132|UniProtKB=F1M7D0	Protein Pcdhb2	ISS	8120095	PubMed	PTHR24028:SF77	PROTOCADHERIN BETA-2
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000018378|UniProtKB=F7H1C6	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02784	Tyrosine biosynthesis	P03213	Aromatic amino acid aminotransferase	ARATH|TAIR=AT5G53970|UniProtKB=Q9FN30	Probable aminotransferase TAT2	ISS			PTHR11751:SF387	AMINOTRANSFERASE TAT2-RELATED
P02746	Heme biosynthesis	P02972	Ferrochelatase	HUMAN|HGNC=3647|UniProtKB=P22830	Ferrochelatase, mitochondrial	ISS			PTHR11108:SF1	FERROCHELATASE, MITOCHONDRIAL
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00047	PDGF signaling pathway	P01143	ERK	BOVIN|Ensembl=ENSBTAG00000020079|UniProtKB=F1N3T0	Uncharacterized protein	ISS			PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00018	EGF receptor signaling pathway	P00557	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	1171954	gi	PTHR10048:SF14	PI-3 KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	CANLF|Ensembl=ENSCAFG00000005760|UniProtKB=F1PLB3	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	HUMAN|HGNC=3373|UniProtKB=Q09472	Histone acetyltransferase p300	TAS	10664585	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00010	B cell activation	P00388	PLC gamma2	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00054	Toll receptor signaling pathway	P01352	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00047	PDGF signaling pathway	P01154	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P02774	Salvage pyrimidine deoxyribonucleotides	P03146	Deoxyuridine kinase	LEIMA|EnsemblGenome=LmjF.21.1210|UniProtKB=Q4QC75	Thymidine kinase	ISS			PTHR11441:SF0	THYMIDINE KINASE, CYTOSOLIC
P00059	p53 pathway	P04616	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	15210700	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12707323	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P02787	Vitamin B6 metabolism	P03244	Pyridoxal kinase	BOVIN|Ensembl=ENSBTAG00000018186|UniProtKB=Q0II59	Pyridoxal kinase	ISS	10395444	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=98327|UniProtKB=P30873	Somatostatin receptor type 1	IDA	12441358	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	RAT|RGD=621705|UniProtKB=Q8VHN2	Glutamate receptor ionotropic, NMDA 3B	ISS	11319238	PubMed	PTHR44285:SF3	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00060	Ubiquitin proteasome pathway	P01494	19S proteasome	EMENI|EnsemblGenome=CADANIAG00010185|UniProtKB=C8VJ79	Proteasome regulatory particle subunit Rpt3, putative (AFU_orthologue AFUA_3G11390)	ISS			PTHR23073:SF8	26S PROTEASE REGULATORY SUBUNIT 6B
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05915	Opioid proenkephalin pathway	P05994	G-protein	RAT|RGD=2714|UniProtKB=P08753	Guanine nucleotide-binding protein G(k) subunit alpha	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	RAT|RGD=2027|UniProtKB=P63269	Actin, gamma-enteric smooth muscle	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00012	Cadherin signaling pathway	P00476	Yes	MACMU|Ensembl=ENSMMUG00000004054|UniProtKB=F6ZR07	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF90	TYROSINE-PROTEIN KINASE YES
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-486685|UniProtKB=F6VT32	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01413	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00019	Endothelin signaling pathway	P00568	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00010	B cell activation	P00384	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	12810719	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00056	VEGF signaling pathway	P01423	p38MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00012	Cadherin signaling pathway	P00463	betacatenin	MACMU|Ensembl=ENSMMUG00000014627|UniProtKB=F7GNE4	Catenin beta-1	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P00005	Angiogenesis	P00187	beta catenin	TAKRU|Ensembl=ENSTRUG00000003520|UniProtKB=H2S791	Uncharacterized protein	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	IC	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00021	FGF signaling pathway	P00629	PP2A	BRAFL|Gene=BRAFLDRAFT_123893|UniProtKB=C3XQF4	Serine/threonine-protein phosphatase	ISS	2461222	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	RAT|RGD=1308152|UniProtKB=Q5FVM5	Cyclic AMP-responsive element-binding protein 3-like protein 3	ISS	123810	OMIM	PTHR22952:SF98	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 3
P00019	Endothelin signaling pathway	P00571	Pro ET1-4	PANTR|Ensembl=ENSPTRG00000017730|UniProtKB=H2QSB1	Uncharacterized protein	ISS	12907686	PubMed	PTHR13874:SF10	ENDOTHELIN-1
P04393	Ras Pathway	P04542	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	ISS	15591313	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	P04634	Cdc2	BOVIN|Ensembl=ENSBTAG00000010109|UniProtKB=P48734	Cyclin-dependent kinase 1	ISS			PTHR24056:SF334	CYCLIN-DEPENDENT KINASE 1
P00059	p53 pathway	P01483	Mdm2	BOVIN|Gene=MDM4|UniProtKB=Q2HJ21	Protein Mdm4	ISS			PTHR13844:SF20	PROTEIN MDM4
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04393	Ras Pathway	P04557	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	176872	OMIM	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00006	Apoptosis signaling pathway	P00260	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000000081|UniProtKB=F7HAK5	Uncharacterized protein	ISS	88234494	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04395	Vasopressin synthesis	P04589	Signal Peptidase	TAKRU|Ensembl=ENSTRUG00000004535|UniProtKB=H2SEF0	Signal peptidase complex catalytic subunit SEC11	ISS	2092035	PubMed	PTHR10806:SF6	SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11
P02778	Sulfate assimilation	P03165	Sulfite reductase	ECOLI|EcoGene=EG10191|UniProtKB=P38038	Sulfite reductase [NADPH] flavoprotein alpha-component	ISS			PTHR19384:SF89	SULFITE REDUCTASE  NADPH  FLAVOPROTEIN COMPONENT
P00047	PDGF signaling pathway	P01173	STAT	PANTR|Ensembl=ENSPTRG00000012749|UniProtKB=H2QJ60	Signal transducer and activator of transcription	ISS	14984365	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	ARATH|TAIR=AT5G57980|UniProtKB=Q9FJL8	DNA-directed RNA polymerase subunit 5-like protein 1	ISS	11313498	PubMed	PTHR10535:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04380	Cortocotropin releasing factor receptor signaling pathway	P04455	beta-endorphin	HUMAN|HGNC=9201|UniProtKB=P01189	Pro-opiomelanocortin	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MOUSE|MGI=MGI=1921305|UniProtKB=Q8K4S1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	15611108	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00048	PI3 kinase pathway	P01199	Galpha	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	IC	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05913	Enkephalin release	P05974	G-Protein (i)	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00010	B cell activation	P00384	p38	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00059	p53 pathway	P04623	CBP	ARATH|TAIR=AT1G55970|UniProtKB=Q9LG11	Histone acetyltransferase HAC4	IDA	10823891	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00009	Axon guidance mediated by netrin	P00362	Phospholipase C	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P02770	Pyridoxal phosphate salvage pathway	P03121	Pyridoxal kinase	PSEAE|EnsemblGenome=PA5516|UniProtKB=Q9HT57	Pyridoxal kinase PdxY	ISS	10984043	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-969601|UniProtKB=Q28H40	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00055	Transcription regulation by bZIP transcription factor	P01389	TTF2	MOUSE|MGI=MGI=3704243|UniProtKB=B9EJ57	Transcription termination factor 1b, mitochondrial	ISS			PTHR15437:SF2	TRANSCRIPTION TERMINATION FACTOR 1, MITOCHONDRIAL
P00005	Angiogenesis	P00236	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	14744428	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P05916	Opioid prodynorphin pathway	P06002	G-protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00629	PP2A	DANRE|ZFIN=ZDB-GENE-040426-2086|UniProtKB=Q6NY64	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform	ISS	137056	PubMed	PTHR11871:SF6	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B DELTA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01020	NSF	CHICK|Ensembl=ENSGALG00000001055|UniProtKB=E1BQU4	Uncharacterized protein	ISS	11348590	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P06664	Gonadotropin-releasing hormone receptor pathway	P06861	MAP4Ks	MOUSE|MGI=MGI=1346882|UniProtKB=P70218	Mitogen-activated protein kinase kinase kinase kinase 1	RCA			PTHR24361:SF88	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 1
P00052	TGF-beta signaling pathway	P01284	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04572	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10523642	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00010	B cell activation	P00398	IP3R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IC	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00623	FGF	XENTR|Xenbase=XB-GENE-484332|UniProtKB=L7N2H4	Fibroblast growth factor	ISS	97376484	PubMed	PTHR11486:SF77	FIBROBLAST GROWTH FACTOR 13
P02746	Heme biosynthesis	P02977	Glutamyl-tRNA-synthetase	ARATH|TAIR=AT5G64050|UniProtKB=Q9FEA2	Glutamate--tRNA ligase, chloroplastic/mitochondrial	ISS			PTHR43311:SF2	GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED
P00053	T cell activation	P01320	PLC-gamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00012	Cadherin signaling pathway	P00462	Casein kinase II	TAKRU|Ensembl=ENSTRUG00000000811|UniProtKB=H2RP90	Casein kinase II subunit beta	ISS	10617630	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00021	FGF signaling pathway	P00627	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	20331588	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00020	FAS signaling pathway	P00614	ASK1	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	TAS			PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P02769	Purine metabolism	P03116	Xanthine Oxidase	MOUSE|MGI=MGI=98973|UniProtKB=Q00519	Xanthine dehydrogenase/oxidase	IDA	12969896	PubMed	PTHR11908:SF80	XANTHINE DEHYDROGENASE/OXIDASE
P00047	PDGF signaling pathway	P01151	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	1171954	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	12584202	PubMed	PTHR24070:SF385	GTPASE HRAS
P00009	Axon guidance mediated by netrin	P00363	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	CANLF|Ensembl=ENSCAFG00000004930|UniProtKB=E2RFB5	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	CANLF|Ensembl=ENSCAFG00000011252|UniProtKB=F1Q334	Uncharacterized protein	ISS	9039917	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00034	Integrin signalling pathway	P00922	Collagen	MOUSE|MGI=MGI=88451|UniProtKB=P39061	Collagen alpha-1(XVIII) chain	IDA	10778855	PubMed	PTHR45362:SF1	COLLAGEN ALPHA-1 XVIII  CHAIN
P00012	Cadherin signaling pathway	P00475	Frizzled	BOVIN|Ensembl=ENSBTAG00000020742|UniProtKB=F1MBL4	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF79	FRIZZLED-9
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	7937853	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01185	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	92335328	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00006	Apoptosis signaling pathway	P00274	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	PANTR|Ensembl=ENSPTRG00000010992|UniProtKB=H2QGC2	Uncharacterized protein	ISS	12655147	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	IDA	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00047	PDGF signaling pathway	P01143	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	11251832	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	RAT|RGD=620027|UniProtKB=P08911	Muscarinic acetylcholine receptor M5	IDA	10069496	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00029	Huntington disease	P00786	ARF	BOVIN|Ensembl=ENSBTAG00000002869|UniProtKB=Q3T0M9	ADP-ribosylation factor-like protein 4A	ISS	12932731	PubMed	PTHR11711:SF139	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 4A
P00057	Wnt signaling pathway	P01434	sFRP	PANTR|Ensembl=ENSPTRG00000020192|UniProtKB=H2R9U6	Secreted frizzled-related protein 1	ISS	9096311	PubMed	PTHR11309:SF87	SECRETED FRIZZLED-RELATED PROTEIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	IXOSC|EnsemblGenome=ISCW009711|UniProtKB=B7Q3T6	THO complex subunit, putative	ISS			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS			PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00021	FGF signaling pathway	P00640	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05913	Enkephalin release	P05977	G-Protein (s)	EMENI|EnsemblGenome=CADANIAG00002670|UniProtKB=Q5BH99	G-protein beta subunit [Source:UniProtKB/TrEMBLAcc:O74214]	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MOUSE|MGI=MGI=1321389|UniProtKB=P63024	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	BOVIN|Ensembl=ENSBTAG00000006642|UniProtKB=P00517	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00121	CD44 intracellular fragment	HUMAN|HGNC=1681|UniProtKB=P16070	CD44 antigen	IDA	14871815	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	97248491	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	RAT|RGD=1306040|UniProtKB=Q6QDP7	Cyclic AMP-responsive element-binding protein 3-like protein 2	ISS	608972	OMIM	PTHR22952:SF96	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	TAS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00558	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IGI	9744561	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04398	p53 pathway feedback loops 2	P04660	SIAH-1	MOUSE|MGI=MGI=108064|UniProtKB=P61092	E3 ubiquitin-protein ligase SIAH1A	ISS	14985507	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P00021	FGF signaling pathway	P00627	ERK1-2	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	NAS	9836510	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04391	Oxytocin receptor mediated signaling pathway	P04535	Ca2+ channel	HUMAN|HGNC=1393|UniProtKB=O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	ISS	8838325	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00005	Angiogenesis	P00238	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	8473736	PubMed	PTHR24070:SF385	GTPASE HRAS
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00046	Oxidative stress response	P01132	c-jun	HUMAN|HGNC=6204|UniProtKB=P05412	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00219	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	MONDO|Ensembl=ENSMODG00000005404|UniProtKB=F7G632	Uncharacterized protein (Fragment)	ISS			PTHR42884:SF13	NEUROENDOCRINE CONVERTASE 2
P00057	Wnt signaling pathway	P01448	CBP	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	3755548	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P04397	p53 pathway by glucose deprivation	P04641	Akt	DROME|FlyBase=FBgn0010379|UniProtKB=Q8INB9	RAC serine/threonine-protein kinase	ISS	12719720	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	DANRE|ZFIN=ZDB-GENE-991119-4|UniProtKB=Q9W6T7	Presenilin-1	IDA	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	DROME|FlyBase=FBgn0000273|UniProtKB=P12370	cAMP-dependent protein kinase catalytic subunit	IC	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00029	Huntington disease	P00777	CBP	BOVIN|Ensembl=ENSBTAG00000016198|UniProtKB=E1B8D6	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00048	PI3 kinase pathway	P01188	Gbetagamma	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00034	Integrin signalling pathway	P00951	Jnk	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00053	T cell activation	P01306	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	15210703	PubMed	PTHR24070:SF189	GTPASE NRAS
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	HUMAN|HGNC=1388|UniProtKB=O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	ISS	11976940	PubMed	PTHR10037:SF59	VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A
P00005	Angiogenesis	P00194	Paxillin	MOUSE|MGI=MGI=108295|UniProtKB=Q8VI36	Paxillin	IDA	7579684	PubMed	PTHR24216:SF11	PAXILLIN
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	12475239	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00018	EGF receptor signaling pathway	P00539	14-3-3	MOUSE|MGI=MGI=109194|UniProtKB=P68510	14-3-3 protein eta	IGI	6756037	gi	PTHR18860:SF16	14-3-3 PROTEIN ETA
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	HUMAN|HGNC=18539|UniProtKB=P61266	Syntaxin-1B	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00006	Apoptosis signaling pathway	P00321	HSP70	DANRE|ZFIN=ZDB-GENE-021209-1|UniProtKB=F1QK71	DNA helicase	ISS			PTHR11630:SF42	DNA REPLICATION LICENSING FACTOR MCM5
P00057	Wnt signaling pathway	P01447	Dishevelled	HUMAN|HGNC=3086|UniProtKB=O14641	Segment polarity protein dishevelled homolog DVL-2	ISS	11212302	PubMed	PTHR10878:SF8	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2
P04393	Ras Pathway	P04560	AP1	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	3136397	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00057	Wnt signaling pathway	P01435	SWI/SNF	ANOGA|EnsemblGenome=AGAP005336|UniProtKB=Q7Q7F6	AGAP005336-PA	ISS	11532957	PubMed	PTHR13844:SF7	BRAHMA-ASSOCIATED PROTEIN OF 60 KDA
P00005	Angiogenesis	P00236	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01311	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P06587	Nicotine pharmacodynamics pathway	P06613	CHRNB2	HUMAN|HGNC=1962|UniProtKB=P17787	Neuronal acetylcholine receptor subunit beta-2	TAS	15155845	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	MACMU|Ensembl=ENSMMUG00000031972|UniProtKB=F7GWC3	Actin-related protein 2/3 complex subunit 4	ISS	9230079	PubMed	PTHR22629:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	DANRE|ZFIN=ZDB-GENE-020129-1|UniProtKB=Q5TZF1	Uncharacterized protein	IDA	15737619	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	TAS	10644715	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	BOVIN|Gene=MAPK13|UniProtKB=Q3T0N5	Mitogen-activated protein kinase 13	ISS	12810719	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	IC	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05912	Dopamine receptor mediated signaling pathway	P05967	Ggamma	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00054	Toll receptor signaling pathway	P01358	ERK1	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00060	Ubiquitin proteasome pathway	P01491	E2	CHICK|Ensembl=ENSGALG00000001441|UniProtKB=F1P0G0	Uncharacterized protein	ISS			PTHR24067:SF3	UBIQUITIN-CONJUGATING ENZYME E2 G1
P00021	FGF signaling pathway	P00648	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	22533439	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	10066767	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00018	EGF receptor signaling pathway	P00539	14-3-3	XENTR|Xenbase=XB-GENE-970616|UniProtKB=Q6P4Z5	14-3-3 protein zeta	ISS	10407019	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	PANTR|Ensembl=ENSPTRG00000000902|UniProtKB=H2PZA6	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	DANRE|ZFIN=ZDB-GENE-060312-45|UniProtKB=Q29RC5	Ras-related C3 botulinum toxin substrate 1-like protein	ISS	12676940	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00056	VEGF signaling pathway	P01408	Akt/PKB	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00017	DNA replication	P00527	Histones	ORNAN|Ensembl=ENSOANG00000002161|UniProtKB=F7AME5	Histone H3	ISS	12413958	PubMed	PTHR11426:SF163	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=109277|UniProtKB=Q64143	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	2842690	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P05912	Dopamine receptor mediated signaling pathway	P05955	DBH	HUMAN|HGNC=2689|UniProtKB=P09172	Dopamine beta-hydroxylase	ISS	90219125	PubMed	PTHR10157:SF29	DOPAMINE BETA-HYDROXYLASE
P00021	FGF signaling pathway	P00640	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IGI	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00056	VEGF signaling pathway	P01411	Ras	DICPU|Gene=DICPUDRAFT_91367|UniProtKB=F0ZB76	Putative uncharacterized protein rasD	ISS	6091907	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P05918	p38 MAPK pathway	P06020	p38delta	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P06211	BMP/activin signaling pathway-drosophila	P06251	BMP/activin orthologous ligand	DROME|FlyBase=FBgn0000490|UniProtKB=P07713	Protein decapentaplegic	RCA	http://flybase.org/reports/FBgn0000490.html	Website	PTHR11848:SF234	PROTEIN DECAPENTAPLEGIC
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	ANOGA|EnsemblGenome=AGAP010442|UniProtKB=Q7QDV6	AGAP010442-PA	TAS	11212302	PubMed	PTHR11309:SF90	FRIZZLED-8
P05731	GABA-B receptor II signaling	P05754	Ggamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P02722	Acetate utilization	P02802	Phosphate acetyltransferase	BACTN|EnsemblGenome=BT_3692|UniProtKB=Q8A1G9	Phosphate acetyltransferase	ISS			PTHR43356:SF3	PHOSPHATE ACETYLTRANSFERASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00707	PKA-c	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	2394752	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00925	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	13928886	gi	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00053	T cell activation	P01322	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00547	PP2A	DANRE|ZFIN=ZDB-GENE-030904-6|UniProtKB=Q7ZUQ2	Ppp2r5e1 protein	ISS	11007767	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P02781	Threonine biosynthesis	P03191	Homoserine kinase	LEPIN|EnsemblGenome=LA_2134|UniProtKB=Q8F4A7	Homoserine kinase	ISS			PTHR20861:SF1	HOMOSERINE KINASE
P00005	Angiogenesis	P00203	Erk	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	RAT|RGD=3344|UniProtKB=P10687	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	TAS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00021	FGF signaling pathway	P00632	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05972	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	TAS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00011	Blood coagulation	P00433	uPAR	PANTR|Ensembl=ENSPTRG00000002646|UniProtKB=H2Q245	Uncharacterized protein	ISS			PTHR24264:SF38	UROKINASE-TYPE PLASMINOGEN ACTIVATOR
P00047	PDGF signaling pathway	P01165	SRF	MOUSE|MGI=MGI=106658|UniProtKB=Q9JM73	Serum response factor	ISS	15170389	PubMed	PTHR11945:SF221	SERUM RESPONSE FACTOR
P00012	Cadherin signaling pathway	P00470	F-actin	BOVIN|Ensembl=ENSBTAG00000046332|UniProtKB=P68138	Actin, alpha skeletal muscle	ISS	3487386	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	RAT|RGD=1564076|UniProtKB=Q5BK52	Protein Prkx	ISS	89107990	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P05913	Enkephalin release	P05977	G-Protein (s)	PHYIT|EnsemblGenome=PITG_06376|UniProtKB=D0N4Q3	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta, putative	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00018	EGF receptor signaling pathway	P00565	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	IGI	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00037	Ionotropic glutamate receptor pathway	P01018	Glu1	CAEBR|Gene=CBG18112|UniProtKB=A8XT20	Protein CBR-GLR-1	ISS	12941441	PubMed	PTHR18966:SF297	GLUTAMATE RECEPTOR 1
P00012	Cadherin signaling pathway	P00463	betacatenin	CHICK|Ensembl=ENSGALG00000011905|UniProtKB=F1NHT7	Uncharacterized protein	ISS	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P00020	FAS signaling pathway	P00615	JNK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	ANOGA|EnsemblGenome=AGAP007136|UniProtKB=Q7QIY9	AGAP007136-PA (Fragment)	IDA			PTHR24247:SF117	5-HYDROXYTRYPTAMINE RECEPTOR 2A-RELATED
P00001	Adrenaline and noradrenaline biosynthesis	P00066	DOPA decarb.	HUMAN|HGNC=2719|UniProtKB=P20711	Aromatic-L-amino-acid decarboxylase	ISS	107930	OMIM	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	BOVIN|Ensembl=ENSBTAG00000003276|UniProtKB=F1MY82	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	PANTR|Ensembl=ENSPTRG00000003783|UniProtKB=H2Q3W7	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	HUMAN|HGNC=16767|UniProtKB=Q8TCU5	Glutamate receptor ionotropic, NMDA 3A	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00012	Cadherin signaling pathway	P00471	Cadherin	MOUSE|MGI=MGI=2444314|UniProtKB=Q8BNA6	Protocadherin Fat 3	ISS	8120095	PubMed	PTHR24026:SF49	PROTOCADHERIN FAT 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	PANTR|Ensembl=ENSPTRG00000013500|UniProtKB=H2QKD0	Phosphoinositide phospholipase C	ISS	90355993	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P04393	Ras Pathway	P04553	PAK	BOVIN|Ensembl=ENSBTAG00000010191|UniProtKB=Q08E52	Serine/threonine-protein kinase PAK 1	ISS	14580336	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	TAKRU|Ensembl=ENSTRUG00000000584|UniProtKB=H2RMN2	Uncharacterized protein	ISS	11248120	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	HUMAN|HGNC=4617|UniProtKB=P49841	Glycogen synthase kinase-3 beta	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P02751	Lysine biosynthesis	P03012	N-succinyl-diaminopimelate desuccinylase	THEMA|EnsemblGenome=TM_1666|UniProtKB=Q9X1Z4	Acetylornithine deacetylase	ISS			PTHR43808:SF3	ACETYLORNITHINE DEACETYLASE
P00018	EGF receptor signaling pathway	P00562	p38	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	IGI	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000008270|UniProtKB=H2QBE5	Uncharacterized protein	ISS	12834808	PubMed	PTHR24027:SF319	CADHERIN-1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DANRE|ZFIN=ZDB-GENE-030131-5215|UniProtKB=Q7ZUC1	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF75	VAMP  VESICLE ASSOCIATED MEMBRANE PROTEIN  HOMOLOG
P00029	Huntington disease	P00807	Actin	CAEEL|WormBase=WBGene00000066|UniProtKB=P10986	Actin-4	IDA	10974003	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	RAT|RGD=620307|UniProtKB=O55173	3-phosphoinositide-dependent protein kinase 1	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	CHICK|Ensembl=ENSGALG00000005884|UniProtKB=Q5ZLW4	Uncharacterized protein	ISS			PTHR24361:SF608	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IDA	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P05730	Endogenous cannabinoid signaling	P05751	Galpha	BOVIN|Ensembl=ENSBTAG00000002714|UniProtKB=P63097	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	11535291	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	CHICK|Ensembl=ENSGALG00000005332|UniProtKB=F1N8C9	Uncharacterized protein	IDA	11956331	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	HUMAN|HGNC=17300|UniProtKB=Q7Z7C8	Transcription initiation factor TFIID subunit 8	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CANLF|Ensembl=ENSCAFG00000007692|UniProtKB=E2QUL2	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00025	Hedgehog signaling pathway	P00682	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00186	FGFR-1	MOUSE|MGI=MGI=95522|UniProtKB=P16092	Fibroblast growth factor receptor 1	ISS	1708247	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P00007	Axon guidance mediated by semaphorins	P00340	Rac	BOVIN|Ensembl=ENSBTAG00000011043|UniProtKB=Q9TU25	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00826	Galphaq	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00059	p53 pathway	G01579	PTEN	RAT|RGD=61995|UniProtKB=O54857	Phosphatase and tensin homolog, isoform CRA_a	IGI	14526383	PubMed	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00024	Glycolysis	P00680	Phosphoglyceromutase	MOUSE|MGI=MGI=1098242|UniProtKB=P15327	Bisphosphoglycerate mutase	ISS	87055234	PubMed	PTHR11931:SF11	BISPHOSPHOGLYCERATE MUTASE
P00015	Circadian clock system	P00505	Cry	ORNAN|Ensembl=ENSOANG00000005350|UniProtKB=F6X852	Uncharacterized protein	ISS	10217146	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00021	FGF signaling pathway	P00623	FGF	MACMU|Ensembl=ENSMMUG00000012484|UniProtKB=F7FAV0	Fibroblast growth factor	ISS	9847253	PubMed	PTHR11486:SF77	FIBROBLAST GROWTH FACTOR 13
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00057	Wnt signaling pathway	P01465	Ggamma	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IDA	2122451	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00054	Toll receptor signaling pathway	P01358	ERK1	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00046	Oxidative stress response	P01135	p38	DROME|FlyBase=FBgn0024846|UniProtKB=O61443	Mitogen-activated protein kinase 14B	TAS	10514528	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000021434|UniProtKB=F7CB49	Uncharacterized protein	ISS	6309844	PubMed	PTHR10218:SF233	GUANINE NUCLEOTIDE-BINDING PROTEIN G OLF  SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	MOUSE|MGI=MGI=98729|UniProtKB=Q62312	TGF-beta receptor type-2	TAS	9395284	PubMed	PTHR23255:SF55	TGF-BETA RECEPTOR TYPE-2
P00046	Oxidative stress response	P01124	Myc	BOVIN|Ensembl=ENSBTAG00000008409|UniProtKB=Q2HJ27	Myc proto-oncogene protein	ISS	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00056	VEGF signaling pathway	P01425	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	3045562	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00973	PKB	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04398	p53 pathway feedback loops 2	P04661	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00046	Oxidative stress response	P01131	MKP5	HUMAN|HGNC=3065|UniProtKB=Q9Y6W6	Dual specificity protein phosphatase 10	TAS	11856337	PubMed	PTHR10159:SF299	DUAL SPECIFICITY PROTEIN PHOSPHATASE 10
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	7600581	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00254	GTPase	CHICK|Ensembl=ENSGALG00000003806|UniProtKB=O93467	GTP-binding protein	ISS	12039949	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00029	Huntington disease	P00790	beta-Tubulin	PANTR|Ensembl=ENSPTRG00000010369|UniProtKB=H2QF52	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF253	TUBULIN BETA-4A CHAIN
P00056	VEGF signaling pathway	P01413	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00053	T cell activation	P01337	B7	MOUSE|MGI=MGI=101773|UniProtKB=P42082	T-lymphocyte activation antigen CD86	IDA	7694363	PubMed	PTHR25466:SF2	T-LYMPHOCYTE ACTIVATION ANTIGEN CD86
P02775	Salvage pyrimidine ribonucleotides	P03152	Uridine phosphorylase	HUMAN|HGNC=12576|UniProtKB=Q16831	Uridine phosphorylase 1	ISS			PTHR43691:SF3	URIDINE PHOSPHORYLASE 1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	SCHPO|PomBase=SPAC6G9.11|UniProtKB=Q92356	Synaptobrevin homolog 1	ISS			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	CAEEL|WormBase=WBGene00001681|UniProtKB=P54406	Guanine nucleotide-binding protein subunit gamma	IC			PTHR13809:SF3	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA-RELATED
P00056	VEGF signaling pathway	P01425	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04374	5HT2 type receptor mediated signaling pathway	P04417	5HT transporter	MOUSE|MGI=MGI=96285|UniProtKB=Q60857	Sodium-dependent serotonin transporter	ISS	14653308	PubMed	PTHR11616:SF105	SODIUM-DEPENDENT SEROTONIN TRANSPORTER
P00036	Interleukin signaling pathway	P00966	mTOR	HUMAN|HGNC=3942|UniProtKB=P42345	Serine/threonine-protein kinase mTOR	IPI	8662507	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00005	Angiogenesis	P00236	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00373	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	15572354	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	15696159	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00057	Wnt signaling pathway	P01460	Casein Kinase 1	SCHPO|PomBase=SPAC1805.05|UniProtKB=O74135	Casein kinase I homolog 3	IDA	11437445	PubMed	PTHR11909:SF155	GILGAMESH, ISOFORM L
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=97583|UniProtKB=P26450	Phosphatidylinositol 3-kinase regulatory subunit alpha	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00021	FGF signaling pathway	P00632	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00053	T cell activation	P01309	fos	PANTR|Ensembl=ENSPTRG00000006553|UniProtKB=A5A6H0	C-fos	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01407	Erk	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02737	Cysteine biosynthesis	P02887	O-Acetylserine-lyase	SULSO|EnsemblGenome=SSO0360|UniProtKB=Q980F2	Cysteine synthase B (CysM)	ISS			PTHR10314:SF159	CYSTEINE SYNTHASE A
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	TAS	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P02771	Pyrimidine Metabolism	P03129	Aminotransferase	RAT|RGD=620948|UniProtKB=P50554	4-aminobutyrate aminotransferase, mitochondrial	IDA	10989446	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	CHICK|Ensembl=ENSGALG00000027561|UniProtKB=R4GKD1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00030	Hypoxia response via HIF activation	P00823	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	1171954	gi	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00005	Angiogenesis	P00221	JNK1	DROME|FlyBase=FBgn0000229|UniProtKB=P92208	Stress-activated protein kinase JNK	ISS	11707292	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00012	Cadherin signaling pathway	P00466	EGFR	ORNAN|Ensembl=ENSOANG00000007021|UniProtKB=F7GAV2	Receptor protein-tyrosine kinase	ISS	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00012	Cadherin signaling pathway	P00474	Wnt	PANTR|Ensembl=ENSPTRG00000002849|UniProtKB=H2Q2F4	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	MACMU|Ensembl=ENSMMUG00000012405|UniProtKB=F7EA82	Uncharacterized protein	ISS	11055438	PubMed	PTHR10117:SF56	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 1
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000014951|UniProtKB=H2QMN4	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	ISS	10704417	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00057	Wnt signaling pathway	P01446	Calcineurin	MACMU|Ensembl=ENSMMUG00000015714|UniProtKB=F6SFE0	Serine/threonine-protein phosphatase	ISS	12015605	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01432	Beta-Catenin	RAT|RGD=70487|UniProtKB=Q9WU82	Catenin beta-1	IDA	116806	OMIM	PTHR23315:SF53	CATENIN BETA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01068	PLC	MACMU|Ensembl=ENSMMUG00000001012|UniProtKB=F6SQC1	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04397	p53 pathway by glucose deprivation	P04641	Akt	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	IDA	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05915	Opioid proenkephalin pathway	P05994	G-protein	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00828	Galphai	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	RCA			PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00828	Galphai	PANTR|Ensembl=ENSPTRG00000019343|UniProtKB=H2QUU5	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	RCA			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00019	Endothelin signaling pathway	P00577	PI3K	CANLF|Ensembl=ENSCAFG00000007626|UniProtKB=F1Q2Q9	Uncharacterized protein	ISS	129387	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00030	Hypoxia response via HIF activation	P00823	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14507992	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00010	B cell activation	P00373	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	10747026	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00058	mRNA splicing	P01476	U4	NEUCR|EnsemblGenome=EFNCRG00000001817|UniProtKB=Q1K4S2	U4/U6 small nuclear ribonucleoprotein	ISS			PTHR14212:SF0	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	PANTR|Ensembl=ENSPTRG00000019501|UniProtKB=H2QV39	Guanine nucleotide binding protein (G protein), beta polypeptide 2	ISS	10391901	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00018	EGF receptor signaling pathway	P00547	PP2A	IXOSC|EnsemblGenome=ISCW014549|UniProtKB=B7QGY5	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	HUMAN|HGNC=9509|UniProtKB=P49810	Presenilin-2	TAS	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00023	General transcription regulation	P00662	TFIIA complex	CAEEL|WormBase=WBGene00015150|UniProtKB=Q9BIB4	Transcription initiation factor IIA small chain homolog	ISS	95241493	PubMed	PTHR10966:SF2	TRANSCRIPTION INITIATION FACTOR IIA SMALL CHAIN HOMOLOG
P04398	p53 pathway feedback loops 2	P04660	SIAH-1	CHICK|Ensembl=ENSGALG00000003916|UniProtKB=F1P2G0	E3 ubiquitin-protein ligase	ISS	14985507	PubMed	PTHR10315:SF23	E3 UBIQUITIN-PROTEIN LIGASE SIAH1
P04377	Beta1 adrenergic receptor signaling pathway	P04433	Beta1	MOUSE|MGI=MGI=87937|UniProtKB=P34971	Beta-1 adrenergic receptor	ISS	12730078	PubMed	PTHR24248:SF54	BETA-1 ADRENERGIC RECEPTOR
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00029	Huntington disease	P00786	ARF	PANTR|Ensembl=ENSPTRG00000018942|UniProtKB=H2QZJ8	ADP-ribosylation factor-like 4A	ISS	12932731	PubMed	PTHR11711:SF139	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 4A
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	HUMAN|HGNC=7578|UniProtKB=P13535	Myosin-8	ISS	10938134	PubMed	PTHR13140:SF368	MYOSIN-8
P02775	Salvage pyrimidine ribonucleotides	P03154	Cytidine deaminase	ECOLI|EcoGene=EG11372|UniProtKB=P68398	tRNA-specific adenosine deaminase	ISS			PTHR11079:SF149	TRNA-SPECIFIC ADENOSINE DEAMINASE
P00049	Parkinson disease	P01242	Casein kinase I	ARATH|TAIR=AT1G72710|UniProtKB=Q9CAI5	At1g72710	IDA	10617630	PubMed	PTHR11909:SF18	CASEIN KINASE I ISOFORM EPSILON
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P06959	CCKR signaling map	P07123	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	RCA	9705935	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00047	PDGF signaling pathway	P01161	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01057	G-Protein	BOVIN|Ensembl=ENSBTAG00000019988|UniProtKB=F1N2V3	Uncharacterized protein	ISS	11534853	PubMed	PTHR10218:SF217	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15
P00060	Ubiquitin proteasome pathway	P01491	E2	MONDO|Ensembl=ENSMODG00000024678|UniProtKB=F7G2B2	Uncharacterized protein	ISS			PTHR24067:SF3	UBIQUITIN-CONJUGATING ENZYME E2 G1
P00004	Alzheimer disease-presenilin pathway	P00171	Notch N-terminal fragment	BOVIN|Ensembl=ENSBTAG00000007909|UniProtKB=F1MPE9	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P02726	Aminobutyrate degradation	P02824	Succinate semi-aldehyde dehydrogenase	MACMU|Ensembl=ENSMMUG00000019368|UniProtKB=F6T9P0	Uncharacterized protein	ISS	12891648	PubMed	PTHR43353:SF5	SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TAKRU|Ensembl=ENSTRUG00000005447|UniProtKB=P68142	Actin, cytoplasmic 1	IC	11889126	PubMed	PTHR11937:SF354	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00572	MEK	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04397	p53 pathway by glucose deprivation	P04641	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	MONDO|Ensembl=ENSMODG00000009988|UniProtKB=F6UST7	Uncharacterized protein	ISS	2433589	PubMed	PTHR11767:SF17	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 3
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008026|UniProtKB=H2QAZ2	Syntaxin 1B	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	RAT|RGD=2627|UniProtKB=P10158	Fos-related antigen 1	ISS	10664585	PubMed	PTHR23351:SF6	FOS-RELATED ANTIGEN 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000015080|UniProtKB=F7GR36	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	10395542	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	HUMAN|HGNC=11131|UniProtKB=O00161	Synaptosomal-associated protein 23	IC	11067767	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00053	T cell activation	P01309	fos	PANTR|Ensembl=ENSPTRG00000006553|UniProtKB=A5A6H0	C-fos	ISS	6514007	PubMed	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00049	Parkinson disease	P01219	SAPK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	NAS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00048	PI3 kinase pathway	P01176	JAK	HUMAN|HGNC=6192|UniProtKB=O60674	Tyrosine-protein kinase JAK2	ISS	22482294	PubMed	PTHR24418:SF179	TYROSINE-PROTEIN KINASE JAK2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=94926|UniProtKB=P51436	D(4) dopamine receptor	IDA	2039532	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P00018	EGF receptor signaling pathway	P00562	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	15143069	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00012	Cadherin signaling pathway	P00471	Cadherin	MACMU|Ensembl=ENSMMUG00000006009|UniProtKB=F6UDC8	Uncharacterized protein	ISS	8120095	PubMed	PTHR24027:SF272	CADHERIN-24
P04395	Vasopressin synthesis	P04593	Glycopeptide	BOVIN|Ensembl=ENSBTAG00000008026|UniProtKB=P01175	Oxytocin-neurophysin 1	IC	192340	OMIM	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00049	Parkinson disease	P01211	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IDA	12925581	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00893	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12801936	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	DICPU|Gene=DICPUDRAFT_46519|UniProtKB=F0Z796	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00004	Alzheimer disease-presenilin pathway	P00179	Notch extracellular fragment	BOVIN|Ensembl=ENSBTAG00000007909|UniProtKB=F1MPE9	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00047	PDGF signaling pathway	P01145	c-fos	DANRE|ZFIN=ZDB-GENE-031222-4|UniProtKB=Q6P0S4	Uncharacterized protein	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00014	Cholesterol biosynthesis	P00491	Hydroxymethyl glutaryl CoA reductase	PANTR|Ensembl=ENSPTRG00000016994|UniProtKB=H2QR35	3-hydroxy-3-methylglutaryl coenzyme A reductase	ISS	P00347	SPACC	PTHR10572:SF2	3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE
P00057	Wnt signaling pathway	P01448	CBP	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04393	Ras Pathway	P04555	PDK	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	IDA	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00019	Endothelin signaling pathway	P00590	IP3 R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IGI	9065779	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	CANLF|Ensembl=ENSCAFG00000002046|UniProtKB=E2RBE7	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF1	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-11
P00047	PDGF signaling pathway	P01168	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IC	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00060	Ubiquitin proteasome pathway	P01491	E2	MACMU|Ensembl=ENSMMUG00000022667|UniProtKB=F7GU37	Uncharacterized protein	ISS			PTHR43898:SF4	UBIQUITIN-CONJUGATING ENZYME E2 A
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00006	Apoptosis signaling pathway	P00273	p53	HUMAN|HGNC=11998|UniProtKB=P04637	Cellular tumor antigen p53	IDA	12932731	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00018	EGF receptor signaling pathway	P00548	RKIP	CHICK|Ensembl=ENSGALG00000002194|UniProtKB=F1NVA9	Uncharacterized protein	ISS			PTHR11362:SF6	39S RIBOSOMAL PROTEIN L38, MITOCHONDRIAL
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00006	Apoptosis signaling pathway	P00303	c-Jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00010	B cell activation	P00381	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	IGI	12663662	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	BRAFL|Gene=BRAFLDRAFT_126324|UniProtKB=C3XYC2	Putative uncharacterized protein	IC	14684598	PubMed	PTHR11937:SF351	ACTIN, CYTOPLASMIC 1-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P05915	Opioid proenkephalin pathway	P05994	G-protein	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MONDO|Ensembl=ENSMODG00000005363|UniProtKB=F6YLB3	Uncharacterized protein	ISS	11554549	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00021	FGF signaling pathway	P00642	MEK1-2	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00034	Integrin signalling pathway	P00936	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00586	Gq	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	IC	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00047	PDGF signaling pathway	P01150	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00759	PDEalphabeta	MOUSE|MGI=MGI=97524|UniProtKB=P27664	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	RCA	P27664	SPACC	PTHR11347:SF115	ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA
P02743	Formyltetrahydroformate biosynthesis	P02953	Cobalamin dependent homocysteine transmethylase	ORYSJ|EnsemblGenome=OS01G0772900|UniProtKB=Q5ZBZ6	Os01g0772900 protein	ISS			PTHR21091:SF159	HOMOCYSTEINE S-METHYLTRANSFERASE 3
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	DANRE|ZFIN=ZDB-GENE-040625-35|UniProtKB=Q6IQL9	Novel actin protein	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00009	Axon guidance mediated by netrin	P00363	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-070713-6|UniProtKB=A9JTC8	Gnai3 protein	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	BOVIN|Gene=CACNB1|UniProtKB=Q9MZL7	Voltage-dependent L-type calcium channel subunit beta-1	IC	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12198155	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IC	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01003	KA2	CHICK|Ensembl=ENSGALG00000015434|UniProtKB=F1NU20	Uncharacterized protein	ISS	14567698	PubMed	PTHR18966:SF38	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2
P00006	Apoptosis signaling pathway	P00318	PKCs	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00006	Apoptosis signaling pathway	P00310	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00543	ERK1-2	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IGI	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00006	Apoptosis signaling pathway	P00283	A1	MOUSE|MGI=MGI=1278327|UniProtKB=Q0P538	B-cell leukemia/lymphoma 2 related protein A1c	IGI	11964303	PubMed	PTHR11256:SF10	BCL-2-RELATED PROTEIN A1
P00047	PDGF signaling pathway	P01150	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00005	Angiogenesis	P00223	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	8437858	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	12707323	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00029	Huntington disease	P00794	Hippi	HUMAN|HGNC=17367|UniProtKB=Q9NWB7	Intraflagellar transport protein 57 homolog	IDA	11889126	PubMed	PTHR16011:SF0	INTRAFLAGELLAR TRANSPORT PROTEIN 57 HOMOLOG
P02780	Thiamin metabolism	P03176	Thiamine kinase	SCHPO|PomBase=SPAC6F12.05c|UniProtKB=P41888	Thiamine pyrophosphokinase	IDA	7499352	PubMed	PTHR13622:SF8	THIAMIN PYROPHOSPHOKINASE 1
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	14765990	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	MOUSE|MGI=MGI=96623|UniProtKB=P11881	Inositol 1,4,5-trisphosphate receptor type 1	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=2136737|UniProtKB=Q91XZ7	Protein Pcdhb3	IDA	8120095	PubMed	PTHR24028:SF118	PROTOCADHERIN BETA-3
P00047	PDGF signaling pathway	P01159	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	476780	gi	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02919	dTDP kinase	DROME|FlyBase=FBgn0000150|UniProtKB=P08879	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P02787	Vitamin B6 metabolism	P03236	Pyridoxamine phosphate oxidase	HUMAN|HGNC=30260|UniProtKB=Q9NVS9	Pyridoxine-5'-phosphate oxidase	ISS	9601034	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	RCA	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	ANOGA|EnsemblGenome=AGAP005911|UniProtKB=Q7Q6D4	AGAP005911-PA	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04393	Ras Pathway	P04544	Grb2	BOVIN|Ensembl=ENSBTAG00000004736|UniProtKB=Q3T0F9	Growth factor receptor-bound protein 2	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P02763	Peptidoglycan biosynthesis	P03090	N-Acetylglucosaminyl transferase	THEMA|EnsemblGenome=TM_0232|UniProtKB=Q9WY74	UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase	ISS			PTHR21015:SF22	GLYCOSYLTRANSFERASE
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	11752399	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	DICDI|dictyBase=DDB_G0279407|UniProtKB=P02599	Calmodulin	ISS	7514101	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00047	PDGF signaling pathway	P01175	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	8264585	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	11067767	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00029	Huntington disease	P00807	Actin	HUMAN|HGNC=169|UniProtKB=P61160	Actin-related protein 2	IDA	11889126	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	15572268	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	P00562	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00561	STAT	MONDO|Ensembl=ENSMODG00000014836|UniProtKB=F7D2D3	Signal transducer and activator of transcription	ISS	8732682	PubMed	PTHR11801:SF39	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
P00060	Ubiquitin proteasome pathway	P01491	E2	IXOSC|EnsemblGenome=ISCW018551|UniProtKB=B7PKN3	Ubiquitin protein ligase	ISS			PTHR24068:SF74	FI16911P1-RELATED
P00029	Huntington disease	P00805	Akt	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00030	Hypoxia response via HIF activation	P00823	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	1171954	gi	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00001	Adrenaline and noradrenaline biosynthesis	P00067	MAO	RAT|RGD=61898|UniProtKB=P21396	Amine oxidase [flavin-containing] A	ISS	8602220	PubMed	PTHR43563:SF3	AMINE OXIDASE  FLAVIN-CONTAINING  A
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	IDA	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00029	Huntington disease	P00795	BDNF	ORNAN|Ensembl=ENSOANG00000013030|UniProtKB=O02795	Brain-derived neurotrophic factor (Fragment)	ISS	12117585	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P05912	Dopamine receptor mediated signaling pathway	P05957	K+ channel	MOUSE|MGI=MGI=1100509|UniProtKB=O35111	Potassium channel subfamily K member 3	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00059	p53 pathway	P01486	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12048203	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00648	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	3755548	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	IDA	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00113	Erb-B4 transmembrane fragment	CHICK|Ensembl=ENSGALG00000003126|UniProtKB=F1P258	Receptor protein-tyrosine kinase	ISS	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	1823142	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00004	Alzheimer disease-presenilin pathway	P00168	E-cadherin intracellular fragment	MOUSE|MGI=MGI=88354|UniProtKB=P09803	Cadherin-1	IDA	8120095	PubMed	PTHR24027:SF319	CADHERIN-1
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	XENTR|Xenbase=XB-GENE-1010483|UniProtKB=F7AF72	Uncharacterized protein	ISS	10331083	PubMed	PTHR18966:SF151	GLUTAMATE RECEPTOR 3
P00047	PDGF signaling pathway	P01154	Ras	XENTR|Xenbase=XB-GENE-494548|UniProtKB=F7EC26	Uncharacterized protein	ISS	20362513	PubMed	PTHR24070:SF186	GTPASE KRAS
P04397	p53 pathway by glucose deprivation	P04643	PP2A-C	CANLF|Ensembl=ENSCAFG00000006453|UniProtKB=F6X958	Serine/threonine-protein phosphatase	ISS	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00019	Endothelin signaling pathway	P00587	Raf-1	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05961	DOPA decarb.	MACMU|Ensembl=ENSMMUG00000019991|UniProtKB=F7FNW0	Aromatic-L-amino-acid decarboxylase	ISS	107930	OMIM	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P02747	Histidine biosynthesis	P02992	Imidazol glycerol phosphate synthase	THEMA|EnsemblGenome=TM_1036|UniProtKB=Q9X0C6	Imidazole glycerol phosphate synthase subunit HisF	ISS			PTHR21235:SF2	IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DANRE|ZFIN=ZDB-GENE-050114-6|UniProtKB=A3KMS9	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	15611108	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00057	Wnt signaling pathway	P01453	Ebi	PANTR|Ensembl=ENSPTRG00000015639|UniProtKB=H2QNR9	Transducin (Beta)-like 1 X-linked receptor 1	ISS	11389839	PubMed	PTHR22846:SF40	F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN TBL1XR1
P00018	EGF receptor signaling pathway	P00555	MKK4,7	MACMU|Ensembl=ENSMMUG00000019842|UniProtKB=F7FU91	Uncharacterized protein	ISS	7716521	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P04393	Ras Pathway	P04564	MAPKAP	MACMU|Ensembl=ENSMMUG00000010495|UniProtKB=F7BFL2	MAP kinase-activated protein kinase 3	ISS	11157753	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P00048	PI3 kinase pathway	P01188	Gbetagamma	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P02747	Histidine biosynthesis	P02984	Imidazol glycerol phosphate dehydratase	GLOVI|EnsemblGenome=BAC88710|UniProtKB=Q7NMJ6	Imidazoleglycerol-phosphate dehydratase	ISS			PTHR23133:SF2	IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PANTR|Ensembl=ENSPTRG00000018890|UniProtKB=Q5R1X3	Actin, cytoplasmic 1	ISS	10974003	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00565	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10644715	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	METAC|EnsemblGenome=MA_4331|UniProtKB=Q8TI26	TATA-box-binding protein 1	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05928	Raf1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	BOVIN|Ensembl=ENSBTAG00000016198|UniProtKB=E1B8D6	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00003	Alzheimer disease-amyloid secretase pathway	P00083	Muscarinic acetylcholine receptors	RAT|RGD=620023|UniProtKB=P10980	Muscarinic acetylcholine receptor M2	TAS	11166329	PubMed	PTHR43914:SF1	MUSCARINIC ACETYLCHOLINE RECEPTOR M2
P00010	B cell activation	P00402	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10797012	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00029	Huntington disease	P00776	c-Jun	XENTR|Xenbase=XB-GENE-482228|UniProtKB=F6RYL1	Uncharacterized protein	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	RAT|RGD=1307994|UniProtKB=B6RK61	Myosin heavy chain 7B	ISS	89264452	PubMed	PTHR13140:SF358	MYOSIN-7B
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00036	Interleukin signaling pathway	P00973	PKB	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00709	Glycogen synthase D	RAT|RGD=1589798|UniProtKB=A2RRU1	Glycogen [starch] synthase, muscle	ISS	4212312	PubMed	PTHR10176:SF2	GLYCOGEN  STARCH  SYNTHASE, MUSCLE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3755547	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00010	B cell activation	P00384	p38	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00012	Cadherin signaling pathway	P00477	GSK3beta	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	IDA	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00020	FAS signaling pathway	P00616	Nuclear Lamin	MOUSE|MGI=MGI=96795|UniProtKB=P14733	Lamin-B1	TAS	11165516	PubMed	PTHR23239:SF157	LAMIN-B1
P00005	Angiogenesis	P00223	Akt	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	14523027	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00786	ARF	USTMA|Gene=UMAG_00387|UniProtKB=A0A0D1CG61	Chromosome 1, whole genome shotgun sequence	ISS	12932731	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00047	PDGF signaling pathway	P01143	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00807	Actin	TAKRU|Ensembl=ENSTRUG00000005494|UniProtKB=P53483	Actin, alpha anomalous	IDA	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=11333|UniProtKB=P31391	Somatostatin receptor type 4	IDA	12441358	PubMed	PTHR24229:SF52	SOMATOSTATIN RECEPTOR TYPE 4
P00021	FGF signaling pathway	P00623	FGF	PANTR|Ensembl=ENSPTRG00000016853|UniProtKB=H2QQU8	Fibroblast growth factor	ISS	12941620	PubMed	PTHR11486:SF21	FIBROBLAST GROWTH FACTOR 10
P00034	Integrin signalling pathway	P00936	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	TAS	12655147	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00587	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00039	Metabotropic glutamate receptor group III pathway	P01039	NMDA	CHICK|Ensembl=ENSGALG00000008898|UniProtKB=F1P2J9	Uncharacterized protein	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P04393	Ras Pathway	P04550	Ral	MOUSE|MGI=MGI=1927244|UniProtKB=Q9JIW9	Ras-related protein Ral-B	ISS	7687439	PubMed	PTHR24070:SF199	RAS-RELATED PROTEIN RAL-B
P04393	Ras Pathway	P04557	MEK	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	IDA	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P02772	Pyruvate metabolism	P03138	Malate Dehydrogenase	PSEAE|EnsemblGenome=PA1252|UniProtKB=Q9I492	Delta(1)-pyrroline-2-carboxylate/Delta(1)-piperideine-2-carboxylate reductase	ISS	10984043	PubMed	PTHR11091:SF0	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01188	Gbetagamma	BOVIN|Ensembl=ENSBTAG00000047325|UniProtKB=P50154	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IC	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	12660731	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	ARATH|TAIR=AT1G01560|UniProtKB=Q9LMM5	Mitogen-activated protein kinase 11	ISS			PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00859	NFkappaB	MOUSE|MGI=MGI=97897|UniProtKB=P15307	Proto-oncogene c-Rel	IDA	9480976	PubMed	PTHR24169:SF4	PROTO-ONCOGENE C-REL
P00047	PDGF signaling pathway	P01143	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	21150461	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00029	Huntington disease	P00807	Actin	RAT|RGD=2025|UniProtKB=P68136	Actin, alpha skeletal muscle	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00034	Integrin signalling pathway	P00927	Rac	DICDI|dictyBase=DDB_G0268622|UniProtKB=P34145	Rho-related protein rac1B	IGI	8649368	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00059	p53 pathway	G04697	B99	MACMU|Ensembl=ENSMMUG00000008136|UniProtKB=F7HGK9	Uncharacterized protein	ISS	12750368	PubMed	PTHR21584:SF10	G2 AND S PHASE-EXPRESSED PROTEIN 1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	XENTR|Xenbase=XB-GENE-494358|UniProtKB=F7DD95	Uncharacterized protein	ISS	11739336	PubMed	PTHR11848:SF130	INHIBIN BETA C CHAIN
P04393	Ras Pathway	P04570	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01129	JNK1/2	XENTR|Xenbase=XB-GENE-1217556|UniProtKB=F6TKL3	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00045	Notch signaling pathway	G01541	E(spl)-C genes	MOUSE|MGI=MGI=1341884|UniProtKB=Q9QUS4	Hairy/enhancer-of-split related with YRPW motif protein 2	ISS			PTHR10985:SF88	HAIRY/ENHANCER-OF-SPLIT RELATED WITH YRPW MOTIF PROTEIN 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01447	Dishevelled	CANLF|Ensembl=ENSCAFG00000012180|UniProtKB=F1PIB1	Uncharacterized protein	ISS	11212302	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P00037	Ionotropic glutamate receptor pathway	P01020	NSF	BOVIN|Ensembl=ENSBTAG00000008442|UniProtKB=F1MZU2	Uncharacterized protein	ISS	11348590	PubMed	PTHR23078:SF3	VESICLE-FUSING ATPASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	BOVIN|Ensembl=ENSBTAG00000018989|UniProtKB=A5D7D8	GRM3 protein	ISS	9407094	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00030	Hypoxia response via HIF activation	P00819	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	TAS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MACMU|Ensembl=ENSMMUG00000005818|UniProtKB=F6VL43	Guanine nucleotide-binding protein G(K) subunit alpha	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00006	Apoptosis signaling pathway	P00314	MKK3	CANLF|Ensembl=ENSCAFG00000018530|UniProtKB=F1PXD3	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00006	Apoptosis signaling pathway	P00257	Bcl-xL	RAT|RGD=2200|UniProtKB=P53563	Bcl-2-like protein 1	ISS	7828536	PubMed	PTHR11256:SF12	BCL-2-LIKE PROTEIN 1
P00018	EGF receptor signaling pathway	P00541	Spry	PANTR|Ensembl=ENSPTRG00000016424|UniProtKB=H2QQ50	Sprouty homolog 1, antagonist of FGF signaling	ISS	98117253	PubMed	PTHR12365:SF10	PROTEIN SPROUTY HOMOLOG 1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	IC	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04393	Ras Pathway	P04542	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04395	Vasopressin synthesis	P04593	Glycopeptide	PANTR|Ensembl=ENSPTRG00000013189|UniProtKB=H2QJV1	Uncharacterized protein	ISS	192340	OMIM	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00006	Apoptosis signaling pathway	P00321	HSP70	CHICK|Gene=HSPA8|UniProtKB=O73885	Heat shock cognate 71 kDa protein	ISS	12150907	PubMed	PTHR19375:SF239	HEAT SHOCK COGNATE 71 KDA PROTEIN
P02738	De novo purine biosynthesis	P02902	ADP reductase	HALSA|EnsemblGenome=VNG_1644G|UniProtKB=Q9HPG8	Ribonucleoside reductase large chain	ISS			PTHR43371:SF1	SUBFAMILY NOT NAMED
P00029	Huntington disease	P00809	Caspase 6	RAT|RGD=70967|UniProtKB=O35397	Caspase-6	ISS	10770929	PubMed	PTHR10454:SF164	CASPASE-6
P00010	B cell activation	P00373	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00044	Nicotinic acetylcholine receptor signaling pathway	P01096	Ca2+ channel	MOUSE|MGI=MGI=88293|UniProtKB=Q99246	Voltage-dependent L-type calcium channel subunit alpha-1D	ISS	10514528	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	BOVIN|Ensembl=ENSBTAG00000006159|UniProtKB=E1BNE9	G protein-activated inward rectifier potassium channel 1	ISS	12374786	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00019	Endothelin signaling pathway	P00589	Akt	CAEEL|WormBase=WBGene00000102|UniProtKB=Q17941	Serine/threonine-protein kinase akt-1	IGI	14526383	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	MACMU|Ensembl=ENSMMUG00000004886|UniProtKB=F7AGT9	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	12471040	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	12767044	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00018	EGF receptor signaling pathway	P00564	Rac	MONDO|Ensembl=ENSMODG00000003244|UniProtKB=F6THF0	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	MOUSE|MGI=MGI=96433|UniProtKB=Q60751	Insulin-like growth factor 1 receptor	ISS	2877871	PubMed	PTHR24416:SF106	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	7822322	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00053	T cell activation	P01322	PI3K	MACMU|Ensembl=ENSMMUG00000014553|UniProtKB=F7GT63	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00034	Integrin signalling pathway	P00906	Rap1	MOUSE|MGI=MGI=1921262|UniProtKB=P61226	Ras-related protein Rap-2b	ISS	8576107	PubMed	PTHR24070:SF194	RAS-RELATED PROTEIN RAP-2B
P00005	Angiogenesis	P00225	MEK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS			PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MONDO|Ensembl=ENSMODG00000004452|UniProtKB=F6R7N8	Uncharacterized protein (Fragment)	ISS	1504106	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00211	GSK3beta	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00057	Wnt signaling pathway	P01428	Frizzled	CHICK|Gene=FZD1|UniProtKB=O57328	Frizzled-1	IDA	8717036	PubMed	PTHR11309:SF81	FRIZZLED-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	11931646	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000002350|UniProtKB=P23726	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00047	PDGF signaling pathway	P01153	GSK3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	2164470	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00017	DNA replication	P00527	Histones	MACMU|Ensembl=ENSMMUG00000032354|UniProtKB=F6TK66	Histone H3	ISS	91033046	PubMed	PTHR11426:SF161	HISTONE H3.2-RELATED
P00029	Huntington disease	P00768	Apaf-1	BOVIN|Ensembl=ENSBTAG00000021661|UniProtKB=F1MUW4	Apoptotic protease-activating factor 1	ISS	10364241	PubMed	PTHR22845:SF5	APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
P00018	EGF receptor signaling pathway	P00545	JNK1-3	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00057	Wnt signaling pathway	P01458	Protein Kinase C	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00045	Notch signaling pathway	P01120	NIcs	RAT|RGD=3188|UniProtKB=Q9QW30	Neurogenic locus notch homolog protein 2	IEP	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00054	Toll receptor signaling pathway	P01352	p38	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	ISS	10995439	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8974|UniProtKB=Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00886	Ras	MOUSE|MGI=MGI=97860|UniProtKB=E9PYG6	Protein Rasa1	ISS	14707121	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00056	VEGF signaling pathway	P01413	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	12927784	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00045	Notch signaling pathway	P01120	NIcs	BOVIN|Ensembl=ENSBTAG00000043971|UniProtKB=E1BPT8	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	8327893	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00005	Angiogenesis	P00222	VEGFR-2	MACMU|Ensembl=ENSMMUG00000012669|UniProtKB=F7E313	Uncharacterized protein	ISS	11824379	PubMed	PTHR24416:SF45	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2
P04398	p53 pathway feedback loops 2	P04651	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	1840681	PubMed	PTHR24070:SF385	GTPASE HRAS
P00012	Cadherin signaling pathway	P00471	Cadherin	DANRE|ZFIN=ZDB-GENE-020731-3|UniProtKB=E7FAU6	Uncharacterized protein	IDA			PTHR24028:SF230	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MONDO|Ensembl=ENSMODG00000009983|UniProtKB=F6USY2	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P04393	Ras Pathway	P04578	Rho	PANTR|Ensembl=ENSPTRG00000014922|UniProtKB=H2QML4	Uncharacterized protein	ISS	12024019	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00018	EGF receptor signaling pathway	P00558	SOS	ORNAN|Ensembl=ENSOANG00000014976|UniProtKB=F7BWW9	Uncharacterized protein	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00021	FGF signaling pathway	P00633	Ras	MOUSE|MGI=MGI=97376|UniProtKB=P08556	GTPase NRas	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00059	p53 pathway	P01486	Akt	MOUSE|MGI=MGI=1345147|UniProtKB=Q9WUA6	RAC-gamma serine/threonine-protein kinase	TAS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00854	CHKR	HUMAN|HGNC=1605|UniProtKB=P51679	C-C chemokine receptor type 4	TAS	11698495	PubMed	PTHR10489:SF608	C-C CHEMOKINE RECEPTOR TYPE 4
P00047	PDGF signaling pathway	P01168	PI3K	PANTR|Ensembl=ENSPTRG00000009983|UniProtKB=H2R6R5	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CAEBR|Gene=CBG02167|UniProtKB=A8WS37	Protein CBG02167	ISS	14684598	PubMed	PTHR11937:SF242	ACTIN-1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	HUMAN|HGNC=7571|UniProtKB=Q9UKX3	Myosin-13	ISS	89264452	PubMed	PTHR13140:SF504	MYOSIN-13
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	MONDO|Ensembl=ENSMODG00000006881|UniProtKB=F6PVT7	Uncharacterized protein	ISS	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00052	TGF-beta signaling pathway	P01287	BAMBI	MONDO|Ensembl=ENSMODG00000008021|UniProtKB=F7CL00	BMP and activin membrane-bound inhibitor homolog	ISS	10519551	PubMed	PTHR15505:SF1	BMP AND ACTIVIN MEMBRANE-BOUND INHIBITOR HOMOLOG
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06834	MAP3Ks	MOUSE|MGI=MGI=1346874|UniProtKB=Q61084	Mitogen-activated protein kinase kinase kinase 3	RCA	8649450	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P05915	Opioid proenkephalin pathway	P05994	G-protein	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	15860573	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P04398	p53 pathway feedback loops 2	P04661	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P02772	Pyruvate metabolism	P03136	Malic enzyme	HUMAN|HGNC=6983|UniProtKB=P48163	NADP-dependent malic enzyme	NAS	9954437	gi	PTHR23406:SF17	NADP-DEPENDENT MALIC ENZYME
P00053	T cell activation	P01322	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IGI	15006556	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	XENTR|Xenbase=XB-GENE-485280|UniProtKB=F6X3B2	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CANLF|Ensembl=ENSCAFG00000023094|UniProtKB=Q076A8	Developmental myosin heavy chain embryonic	ISS	10938134	PubMed	PTHR13140:SF427	MYOSIN-3
P00048	PI3 kinase pathway	P01192	p110	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	11916960	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05730	Endogenous cannabinoid signaling	P05751	Galpha	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	15860573	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00009	Axon guidance mediated by netrin	P00363	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04393	Ras Pathway	P04558	p38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	IDA	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	10799299	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00057	Wnt signaling pathway	P01443	Phospholipase C	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	IDA	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00034	Integrin signalling pathway	P00926	GRAF	PANTR|Ensembl=ENSPTRG00000017362|UniProtKB=H2QRP5	Rho GTPase activating protein 26	ISS	8649427	PubMed	PTHR12552:SF4	RHO GTPASE-ACTIVATING PROTEIN 26
P00053	T cell activation	P01307	SOS	ORNAN|Ensembl=ENSOANG00000013979|UniProtKB=F6URW3	Uncharacterized protein (Fragment)	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00005	Angiogenesis	P00181	SHP2	PANTR|Ensembl=ENSPTRG00000042397|UniProtKB=H2RIH8	Tyrosine-protein phosphatase non-receptor type	ISS	95163101	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00019	Endothelin signaling pathway	P00589	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12697749	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00059	p53 pathway	G04694	p110alpha	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01451	Galpha	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	IDA	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00047	PDGF signaling pathway	P01168	PI3K	RAT|RGD=1310990|UniProtKB=D4A5Q1	Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)	ISS	129387	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	HUMAN|HGNC=8981|UniProtKB=Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	ISS	14526383	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00029	Huntington disease	P00780	Microtubule	MACMU|Ensembl=ENSMMUG00000030028|UniProtKB=F7H0X2	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P00011	Blood coagulation	P00422	FIXa	HUMAN|HGNC=3551|UniProtKB=P00740	Coagulation factor IX	ISS	14270123	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	IC	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00036	Interleukin signaling pathway	P00975	RasGAP	MACMU|Ensembl=ENSMMUG00000003245|UniProtKB=F7DNM3	Ras GTPase-activating protein 1 isoform 1	ISS	8270251	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00053	T cell activation	P01336	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04398	p53 pathway feedback loops 2	P04651	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00015	Circadian clock system	G01501	cry	RAT|RGD=620935|UniProtKB=Q923I8	Cryptochrome-2	IEP	11533252	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	DANRE|ZFIN=ZDB-GENE-060531-50|UniProtKB=F1R6C7	Uncharacterized protein	IEP	10938134	PubMed	PTHR13140:SF676	MYOSIN, HEAVY POLYPEPTIDE 2, FAST MUSCLE SPECIFIC
P00036	Interleukin signaling pathway	P00990	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00034	Integrin signalling pathway	P00906	Rap1	HUMAN|HGNC=9855|UniProtKB=P62834	Ras-related protein Rap-1A	ISS	8576107	PubMed	PTHR24070:SF296	RAS-RELATED PROTEIN RAP-1A
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	DROME|FlyBase=FBgn0004009|UniProtKB=P09615	Protein wingless	TAS	8717036	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	2122451	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00049	Parkinson disease	P01230	Src kinase	HUMAN|HGNC=4037|UniProtKB=P06241	Tyrosine-protein kinase Fyn	IDA	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	TAS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	IC	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00011	Blood coagulation	P00441	FXIIa	MACMU|Ensembl=ENSMMUG00000019816|UniProtKB=F7FY72	Uncharacterized protein	ISS	4503629	gi	PTHR44246:SF3	COAGULATION FACTOR XII
P00047	PDGF signaling pathway	P01173	STAT	MACMU|Ensembl=ENSMMUG00000005617|UniProtKB=F6WDY6	Signal transducer and activator of transcription	ISS	12496413	PubMed	PTHR11801:SF19	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 4
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	MOUSE|MGI=MGI=1353438|UniProtKB=O08911	Mitogen-activated protein kinase 12	IDA	11707292	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P04393	Ras Pathway	P04552	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IDA	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00011	Blood coagulation	P00460	FXI	MACMU|Ensembl=ENSMMUG00000020064|UniProtKB=F7GHR4	Uncharacterized protein	ISS	14270123	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P00010	B cell activation	P00371	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	20283605	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	14997396	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	MOUSE|MGI=MGI=87902|UniProtKB=P68134	Actin, alpha skeletal muscle	ISS	11889126	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00057	Wnt signaling pathway	P01452	NFAT	MACMU|Ensembl=ENSMMUG00000003370|UniProtKB=F7E8G2	Uncharacterized protein	ISS	9462517	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	RCA	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00034	Integrin signalling pathway	P00907	ERK	PANTR|Ensembl=ENSPTRG00000024326|UniProtKB=H2R231	Uncharacterized protein	ISS			PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00029	Huntington disease	P00807	Actin	MOUSE|MGI=MGI=87905|UniProtKB=P68033	Actin, alpha cardiac muscle 1	IDA	11889126	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P05913	Enkephalin release	P05972	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	1319556	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00047	PDGF signaling pathway	P01153	GSK3	ARATH|TAIR=AT5G14640|UniProtKB=Q8VZD5	Shaggy-related protein kinase epsilon	ISS	12615961	PubMed	PTHR24057:SF36	SHAGGY-RELATED PROTEIN KINASE EPSILON
P00019	Endothelin signaling pathway	P00590	IP3 R	BOVIN|Gene=ITPR3|UniProtKB=Q8WN95	Inositol 1,4,5-trisphosphate receptor type 3	IGI	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12676940	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00056	VEGF signaling pathway	P01413	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01333	cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	15723050	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	IC	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8703|UniProtKB=Q9Y5G8	Protocadherin gamma-A5	IDA	8120095	PubMed	PTHR24028:SF105	PROTOCADHERIN GAMMA-A5
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00754	PDEgamma	ORNAN|Ensembl=ENSOANG00000002699|UniProtKB=F6ZK66	Uncharacterized protein	ISS	P54827	SPACC	PTHR12122:SF4	RETINAL ROD RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT GAMMA
P00029	Huntington disease	P00790	beta-Tubulin	ORNAN|Ensembl=ENSOANG00000003049|UniProtKB=F7B0P2	Uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF88	TUBULIN BETA-6 CHAIN
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	ANOGA|Gene=AgaP_AGAP009115|UniProtKB=Q7PW25	Phosphoinositide phospholipase C (Fragment)	ISS	1707501	PubMed	PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00015	Circadian clock system	P00505	Cry	PANTR|Ensembl=ENSPTRG00000003537|UniProtKB=H2Q3H0	Uncharacterized protein	ISS	11533252	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00005	Angiogenesis	P00203	Erk	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04568	MKK3/6	CHICK|Ensembl=ENSGALG00000004735|UniProtKB=F1NHE1	Uncharacterized protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00029	Huntington disease	P00802	PACSIN-1	MACMU|Ensembl=ENSMMUG00000007811|UniProtKB=F7CP60	Uncharacterized protein	ISS	12354780	PubMed	PTHR23065:SF16	PROTEIN KINASE C AND CASEIN KINASE SUBSTRATE IN NEURONS PROTEIN 1
P00035	Interferon-gamma signaling pathway	P00960	PTP	BOVIN|Ensembl=ENSBTAG00000002048|UniProtKB=F1N339	Tyrosine-protein phosphatase non-receptor type	ISS	14525967	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00034	Integrin signalling pathway	P00925	MEK	MOUSE|MGI=MGI=1346868|UniProtKB=O09110	Dual specificity mitogen-activated protein kinase kinase 3	IDA	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00021	FGF signaling pathway	P00627	ERK1-2	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IGI	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000006289|UniProtKB=H2Q875	Uncharacterized protein	ISS	12441358	PubMed	PTHR24229:SF38	SOMATOSTATIN RECEPTOR TYPE 1
P05916	Opioid prodynorphin pathway	P06001	AC	HUMAN|HGNC=238|UniProtKB=P51828	Adenylate cyclase type 7	ISS	2491850	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	IGI	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	PLAF7|EnsemblGenome=PFL1435c|UniProtKB=Q8I5C2	Myosin d	IC			PTHR13140:SF711	SUBFAMILY NOT NAMED
P00019	Endothelin signaling pathway	P00568	PKC	DANRE|ZFIN=ZDB-GENE-040426-1178|UniProtKB=Q7SY24	Protein kinase C beta type	ISS	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01306	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	14704231	PubMed	PTHR24070:SF189	GTPASE NRAS
P00014	Cholesterol biosynthesis	P00490	Dimethylallyl trans-transferase	MACMU|Ensembl=ENSMMUG00000005076|UniProtKB=F7C4K8	Uncharacterized protein	ISS			PTHR12001:SF47	DECAPRENYL-DIPHOSPHATE SYNTHASE SUBUNIT 1
P02754	Methylcitrate cycle	P03031	2-Methylcitrate dehydratase	ECOLI|EcoGene=EG13603|UniProtKB=P77243	2-methylcitrate dehydratase	ISS			PTHR16943:SF25	2-METHYLCITRATE DEHYDRATASE
P00004	Alzheimer disease-presenilin pathway	P00128	Erb-B4	RAT|RGD=620486|UniProtKB=Q62956	Receptor tyrosine-protein kinase erbB-4	IDA	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00048	PI3 kinase pathway	P01181	GSK3	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00005	Angiogenesis	P00182	p38MAPK	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	YEAST|SGD=S000006189|UniProtKB=P32383	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1	ISS			PTHR10336:SF36	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	BOVIN|Gene=VAMP1|UniProtKB=Q0V7N0	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DANRE|ZFIN=ZDB-GENE-040426-1354|UniProtKB=Q7T2C5	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00056	VEGF signaling pathway	P01408	Akt/PKB	RAT|RGD=2081|UniProtKB=P47196	RAC-alpha serine/threonine-protein kinase	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	ISS	11035810	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05915	Opioid proenkephalin pathway	P05994	G-protein	RAT|Ensembl=ENSRNOG00000039562|UniProtKB=F2Z3T8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IDA	15572354	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00025	Hedgehog signaling pathway	P00692	GSK3	XENTR|Xenbase=XB-GENE-487098|UniProtKB=F7ACT4	Uncharacterized protein (Fragment)	ISS	11995474	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00045	Notch signaling pathway	P01108	Nicastrin	HUMAN|HGNC=17091|UniProtKB=Q92542	Nicastrin	TAS	10993067	PubMed	PTHR21092:SF0	NICASTRIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=1921305|UniProtKB=Q8K4S1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	10934033	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00059	p53 pathway	G04694	p110alpha	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00054	Toll receptor signaling pathway	P01358	ERK1	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04398	p53 pathway feedback loops 2	P04665	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	14517300	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00583	cPLA2	MONDO|Ensembl=ENSMODG00000011791|UniProtKB=F7CBU9	Phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	PANTR|Gene=HRH1|UniProtKB=Q9N2B2	Histamine H1 receptor	IDA			PTHR43914:SF2	HISTAMINE H1 RECEPTOR
P00005	Angiogenesis	P00203	Erk	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00775	Rac	HUMAN|HGNC=9802|UniProtKB=P15153	Ras-related C3 botulinum toxin substrate 2	ISS	10540223	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P00021	FGF signaling pathway	P00640	PI3K	DROME|FlyBase=FBgn0015279|UniProtKB=P91634	PI-3 kinase	ISS	14526383	PubMed	PTHR10048:SF14	PI-3 KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	DANRE|ZFIN=ZDB-GENE-991111-3|UniProtKB=Q5U3B4	Insulin-like growth factor 2a	ISS	4504609	gi	PTHR11454:SF10	INSULIN-LIKE GROWTH FACTOR II
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00878	INFgamma	MOUSE|MGI=MGI=107656|UniProtKB=P01580	Interferon gamma	TAS	11929133	PubMed	PTHR11419:SF0	INTERFERON GAMMA
P00006	Apoptosis signaling pathway	P00318	PKCs	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	IDA	10747026	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	MOUSE|MGI=MGI=1313277|UniProtKB=P63044	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	MONDO|Ensembl=ENSMODG00000000219|UniProtKB=F6SZ66	Phosphatidylinositol 3-kinase	ISS	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P02738	De novo purine biosynthesis	P02892	5-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase	FUSNN|EnsemblGenome=FN0368|UniProtKB=Q8RGD3	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P00012	Cadherin signaling pathway	P00470	F-actin	CAEEL|WormBase=WBGene00000064|UniProtKB=P10984	Actin-2	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00104	APPbeta	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	TAS	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00057	Wnt signaling pathway	P01443	Phospholipase C	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	IDA	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MACMU|Ensembl=ENSMMUG00000005905|UniProtKB=F6WWF3	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	XENTR|Xenbase=XB-GENE-976753|UniProtKB=Q0VFR6	Syntaxin 1A (Brain)	ISS	97410052	PubMed	PTHR19957:SF84	SYNTAXIN-1A
P00053	T cell activation	P01332	Akt	CHICK|Ensembl=ENSGALG00000010709|UniProtKB=F1NRC8	Uncharacterized protein	ISS	10092583	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00124	Capacitative calcium channels	RAT|RGD=628820|UniProtKB=F1LQF7	Protein Trpc7	ISS	11055438	PubMed	PTHR10117:SF9	SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 7
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00011	Blood coagulation	P00408	Plasminogen	HUMAN|HGNC=9071|UniProtKB=P00747	Plasminogen	ISS	4505881	gi	PTHR24261:SF6	PLASMINOGEN
P00036	Interleukin signaling pathway	P00964	p90RSK	BOVIN|Ensembl=ENSBTAG00000021741|UniProtKB=F1MNR5	Ribosomal protein S6 kinase	ISS	1922062	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00036	Interleukin signaling pathway	P00973	PKB	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	1718748	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04586	ProTRH (Pro Thyrotropin-releasing Hormone)	PANTR|Ensembl=ENSPTRG00000015383|UniProtKB=H2QNC9	Uncharacterized protein	ISS	2126343	PubMed	PTHR17530:SF2	PRO-THYROTROPIN-RELEASING HORMONE
P00024	Glycolysis	P00680	Phosphoglyceromutase	BOVIN|Ensembl=ENSBTAG00000037625|UniProtKB=E1B959	Uncharacterized protein	ISS	87055234	PubMed	PTHR11931:SF11	BISPHOSPHOGLYCERATE MUTASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000025632|UniProtKB=F6XWE8	Guanine nucleotide-binding protein subunit gamma (Fragment)	ISS	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00010	B cell activation	P00375	Calmodulin	PHYPA|Gene=PHYPADRAFT_185037|UniProtKB=A9SHH7	Predicted protein	ISS			PTHR23050:SF245	AT16150P-RELATED
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00012	Cadherin signaling pathway	P00475	Frizzled	CANLF|Ensembl=ENSCAFG00000004399|UniProtKB=E2RIL8	Uncharacterized protein	ISS	11212302	PubMed	PTHR11309:SF23	FRIZZLED-4
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	BOVIN|Gene=MMP13|UniProtKB=O77656	Collagenase 3	TAS	12834808	PubMed	PTHR10201:SF165	COLLAGENASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Ensembl=ENSCAFG00000019381|UniProtKB=F6XMN6	Protein kinase C	ISS	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00056	VEGF signaling pathway	P01413	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00624	14-3-3	DANRE|ZFIN=ZDB-GENE-030131-6583|UniProtKB=Q5PRD0	14-3-3 protein beta/alpha-A	ISS	9055384	gi	PTHR18860:SF28	14-3-3 PROTEIN BETA/ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	YEAST|SGD=S000002898|UniProtKB=Q03407	Serine/threonine-protein kinase PKH1	ISS	4505695	gi	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	TAS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00029	Huntington disease	P00778	NMDA receptor	HUMAN|HGNC=4584|UniProtKB=Q05586	Glutamate receptor ionotropic, NMDA 1	IDA	92049750	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00048	PI3 kinase pathway	P01199	Galpha	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MACMU|Ensembl=ENSMMUG00000012948|UniProtKB=F6RJC0	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00037	Ionotropic glutamate receptor pathway	P01006	NR2C	RAT|RGD=2739|UniProtKB=Q00961	Glutamate receptor ionotropic, NMDA 2C	ISS	11319238	PubMed	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	CHICK|Ensembl=ENSGALG00000013781|UniProtKB=F1P1D5	Uncharacterized protein	ISS	89264452	PubMed	PTHR13140:SF344	MYOSIN-7
P00004	Alzheimer disease-presenilin pathway	P00115	Nicastrin	DROME|FlyBase=FBgn0039234|UniProtKB=Q9VC27	Nicastrin	IDA	16096062	PubMed	PTHR21092:SF0	NICASTRIN
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	TAS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00004	Alzheimer disease-presenilin pathway	P00165	E-cadherin N-terminal fragment	MOUSE|MGI=MGI=88356|UniProtKB=P10287	Cadherin-3	TAS	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	10704417	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00036	Interleukin signaling pathway	P00983	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	IGI	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00047	PDGF signaling pathway	P01172	c-Myc	RAT|RGD=3130|UniProtKB=P09416	Myc proto-oncogene protein	ISS	12356903	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IDA	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	TAKRU|Ensembl=ENSTRUG00000011562|UniProtKB=H2TX02	Protein Wnt	TAS	11266476	PubMed	PTHR12027:SF91	PROTO-ONCOGENE WNT-1
P00036	Interleukin signaling pathway	P00968	Ikk	MACMU|Ensembl=ENSMMUG00000018476|UniProtKB=F6X938	Uncharacterized protein	ISS	12235208	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00545	JNK1-3	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00226	Delta/Serrate	MACMU|Ensembl=ENSMMUG00000019093|UniProtKB=F6TFS9	Uncharacterized protein	ISS	10742114	PubMed	PTHR24044:SF308	DELTA-LIKE PROTEIN 3
P04393	Ras Pathway	P04568	MKK3/6	MONDO|Ensembl=ENSMODG00000001404|UniProtKB=F7BD74	Uncharacterized protein	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P05918	p38 MAPK pathway	P06021	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12932731	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CAEEL|WormBase=WBGene00004056|UniProtKB=Q8MXI4	Mitogen-activated protein kinase pmk-2	TAS			PTHR24055:SF154	MITOGEN-ACTIVATED PROTEIN KINASE PMK-2
P00034	Integrin signalling pathway	P00927	Rac	DROME|FlyBase=FBgn0010333|UniProtKB=P40792	Ras-related protein Rac1	IGI	95047333	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	BOVIN|Gene=CACNB1|UniProtKB=Q9MZL7	Voltage-dependent L-type calcium channel subunit beta-1	IC	20088160	PubMed	PTHR11824:SF5	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1
P00021	FGF signaling pathway	P00623	FGF	DANRE|ZFIN=ZDB-GENE-980526-178|UniProtKB=P48802	Fibroblast growth factor 3	IGI	12223404	PubMed	PTHR11486:SF26	FIBROBLAST GROWTH FACTOR 3
P00057	Wnt signaling pathway	P01440	Cadherin	MOUSE|MGI=MGI=2136759|UniProtKB=Q91V48	MCG1033322	IDA	8120095	PubMed	PTHR24028:SF98	PROTOCADHERIN BETA-18-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	15572354	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	PHYPA|Gene=PHYPADRAFT_172686|UniProtKB=A9TYG6	Predicted protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00049	Parkinson disease	P01238	14-3-3	SCHPO|PomBase=SPAC17A2.13c|UniProtKB=P42657	DNA damage checkpoint protein rad25	IDA	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00006	Apoptosis signaling pathway	P00269	MAPK	NEUCR|Gene=NCU02393|UniProtKB=V5IKE7	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00036	Interleukin signaling pathway	P00970	Interleukin	HUMAN|HGNC=6025|UniProtKB=P10145	Interleukin-8	TAS	124361	gi	PTHR10179:SF70	INTERLEUKIN-8
P00003	Alzheimer disease-amyloid secretase pathway	P00088	Presenilin N-terminal fragment	PANTR|Ensembl=ENSPTRG00000006510|UniProtKB=H2Q8K1	Presenilin	ISS	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00048	PI3 kinase pathway	G01543	IGFBP1	DANRE|ZFIN=ZDB-GENE-021231-1|UniProtKB=Q8JHX6	Insulin-like growth factor binding protein 1a	ISS			PTHR11551:SF25	INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 1A
P04393	Ras Pathway	P04553	PAK	MACMU|Ensembl=ENSMMUG00000001387|UniProtKB=F7D0B4	Uncharacterized protein	ISS	10508610	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01181	GSK3	DANRE|ZFIN=ZDB-GENE-990714-4|UniProtKB=Q9YH60	Glycogen synthase kinase 3	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P02743	Formyltetrahydroformate biosynthesis	P02958	Dihydrofolate synthase	PSEAE|EnsemblGenome=PA3111|UniProtKB=Q9HZA8	Folylpolyglutamate synthetase	ISS			PTHR11136:SF0	DIHYDROFOLATE SYNTHETASE-RELATED
P00019	Endothelin signaling pathway	P00566	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	HUMAN|HGNC=9412|UniProtKB=Q05513	Protein kinase C zeta type	IDA	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00019	Endothelin signaling pathway	P00572	MEK	XENTR|Xenbase=XB-GENE-478822|UniProtKB=Q66JE6	Mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MACMU|Ensembl=ENSMMUG00000014227|UniProtKB=P56490	Muscarinic acetylcholine receptor M5	IDA			PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00019	Endothelin signaling pathway	P00570	PKA	CRYNJ|EnsemblGenome=CNA05510|UniProtKB=Q5KNS1	cAMP-dependent protein kinase regulatory subunit	IGI	11287622	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	MONDO|Ensembl=ENSMODG00000016595|UniProtKB=F6ZDB2	Uncharacterized protein	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P00053	T cell activation	P01332	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00056	VEGF signaling pathway	P01402	MEK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	ISS			PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	BOVIN|Ensembl=ENSBTAG00000008122|UniProtKB=P63217	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00019	Endothelin signaling pathway	P00589	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	92249329	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00019	Endothelin signaling pathway	P00572	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	9398267	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	HUMAN|HGNC=8590|UniProtKB=Q13153	Serine/threonine-protein kinase PAK 1	ISS	15187108	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00005	Angiogenesis	P00236	PI3K	HUMAN|HGNC=8980|UniProtKB=O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	IDA	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000011385|UniProtKB=F6W7C8	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00006	Apoptosis signaling pathway	P00318	PKCs	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00883	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	92335328	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00011	Blood coagulation	P00460	FXI	HUMAN|HGNC=3551|UniProtKB=P00740	Coagulation factor IX	ISS	14270123	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	ISS	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05913	Enkephalin release	P05974	G-Protein (i)	TAKRU|Ensembl=ENSTRUG00000016110|UniProtKB=H2UW52	Uncharacterized protein	ISS	8327893	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	15313841	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00011	Blood coagulation	P00422	FIXa	MACMU|Ensembl=ENSMMUG00000020064|UniProtKB=F7GHR4	Uncharacterized protein	ISS	14270123	gi	PTHR44064:SF4	COAGULATION FACTOR IX
P00010	B cell activation	P00379	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P05731	GABA-B receptor II signaling	P05754	Ggamma	MONDO|Ensembl=ENSMODG00000007929|UniProtKB=F7GI54	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	CHICK|Ensembl=ENSGALG00000005801|UniProtKB=P09482	Neuronal acetylcholine receptor subunit alpha-4	ISS	85270494	PubMed	PTHR18945:SF401	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	MOUSE|MGI=MGI=95766|UniProtKB=P21278	Guanine nucleotide-binding protein subunit alpha-11	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000023997|UniProtKB=Q3T0Y8	Vesicle-associated membrane protein 8	ISS	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00029	Huntington disease	P00796	Kainate receptor	HUMAN|HGNC=4582|UniProtKB=Q16099	Glutamate receptor ionotropic, kainate 4	IDA	12778120	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00018	EGF receptor signaling pathway	P00562	p38	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00018	EGF receptor signaling pathway	P00545	JNK1-3	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	94232348	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00021	FGF signaling pathway	P00629	PP2A	PANTR|Ensembl=ENSPTRG00000015883|UniProtKB=H2QP63	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B	ISS	12191994	PubMed	PTHR11871:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B GAMMA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14507992	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00054	Toll receptor signaling pathway	P01375	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	ISS	10851062	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	CANAL|CGD=CAL0001524|UniProtKB=Q5A0N3	Ribonucleoside-diphosphate reductase	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	RCA	12860966	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00034	Integrin signalling pathway	P00936	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IPI	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04451	CRHR1	CHICK|Ensembl=ENSGALG00000005657|UniProtKB=F1NGG4	Uncharacterized protein	ISS	11145609	PubMed	PTHR12011:SF274	CORTICOTROPIN-RELEASING FACTOR RECEPTOR 2
P04373	5HT1 type receptor mediated signaling pathway	P04410	5HT vesicular transporter	RAT|RGD=3694|UniProtKB=Q01827	Synaptic vesicular amine transporter	ISS	92370677	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	DANRE|ZFIN=ZDB-GENE-980526-249|UniProtKB=Q9I9I2	Protein Wnt	TAS	8717036	PubMed	PTHR12027:SF7	PROTEIN WNT-11
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02734	Chorismate biosynthesis	P02873	Shikimate dehydrogenase	METAC|EnsemblGenome=MA_4594|UniProtKB=Q8THC3	Shikimate dehydrogenase (NADP(+))	ISS			PTHR21089:SF1	BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE/SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ENTHI|EnsemblGenome=EHI_107290|UniProtKB=B1N2P0	Actin	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00005	Angiogenesis	P00253	Axin	HUMAN|HGNC=903|UniProtKB=O15169	Axin-1	IDA	12549854	PubMed	PTHR10845:SF11	AXIN-1
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00047	PDGF signaling pathway	P01173	STAT	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	15825084	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	BOVIN|Ensembl=ENSBTAG00000013016|UniProtKB=Q3ZCA7	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	1482697	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MONDO|Ensembl=ENSMODG00000001775|UniProtKB=F6WJB1	Uncharacterized protein	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00053	T cell activation	P01319	PAK	PANTR|Ensembl=ENSPTRG00000022187|UniProtKB=Q7YQL4	Serine/threonine-protein kinase PAK 3	ISS	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00005	Angiogenesis	P00238	Ras	CHICK|Ensembl=ENSGALG00000006885|UniProtKB=P08642	GTPase HRas	ISS	3035212	PubMed	PTHR24070:SF385	GTPASE HRAS
P00037	Ionotropic glutamate receptor pathway	P01002	KA3	RAT|RGD=71027|UniProtKB=P42264	Glutamate receptor ionotropic, kainate 3	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00017	DNA replication	P00536	DNA Topisomerase	MOUSE|MGI=MGI=98790|UniProtKB=Q01320	DNA topoisomerase 2-alpha	ISS			PTHR10169:SF46	DNA TOPOISOMERASE 2-ALPHA
P00034	Integrin signalling pathway	P00943	Talin	MACMU|Ensembl=ENSMMUG00000031856|UniProtKB=F7HL22	Uncharacterized protein	ISS	14702644	PubMed	PTHR19981:SF7	MESODERM DEVELOPMENT CANDIDATE 1-RELATED
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000025373|UniProtKB=F6ZZG9	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF168	BETA-ACTIN-LIKE PROTEIN 2
P05912	Dopamine receptor mediated signaling pathway	P05958	Gialpha	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	IC	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00739	AGS3	MONDO|Ensembl=ENSMODG00000002268|UniProtKB=F7CVY1	Uncharacterized protein	ISS	11121039	PubMed	PTHR10098:SF100	G-PROTEIN-SIGNALING MODULATOR 2
P00053	T cell activation	P01312	MEK	RAT|RGD=70495|UniProtKB=Q01986	Dual specificity mitogen-activated protein kinase kinase 1	IDA	8157000	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00023	General transcription regulation	P00668	TFIIB	TAKRU|Ensembl=ENSTRUG00000002246|UniProtKB=H2RYC8	Uncharacterized protein	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P05913	Enkephalin release	P05974	G-Protein (i)	PANTR|Ensembl=ENSPTRG00000006342|UniProtKB=H2Q8A8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00029	Huntington disease	P00796	Kainate receptor	CHICK|Ensembl=ENSGALG00000006638|UniProtKB=R4GGL9	Uncharacterized protein	ISS	1648176	PubMed	PTHR18966:SF171	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4
P00049	Parkinson disease	P01236	Casein kinase II	MONDO|Ensembl=ENSMODG00000014080|UniProtKB=F6R511	Uncharacterized protein (Fragment)	ISS	10806215	PubMed	PTHR24054:SF34	CASEIN KINASE II SUBUNIT ALPHA'
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	LEIMA|EnsemblGenome=LmjF.35.4010|UniProtKB=Q9GNR4	Protein kinase A catalytic subunit isoform 1	ISS	10553940	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	MOUSE|MGI=MGI=893577|UniProtKB=P70452	Syntaxin-4	ISS			PTHR19957:SF97	SYNTAXIN-4
P00053	T cell activation	P01311	Raf	RAT|RGD=2148|UniProtKB=P14056	Serine/threonine-protein kinase A-Raf	ISS	12639709	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	TAKRU|Ensembl=ENSTRUG00000008289|UniProtKB=H2T7U8	Uncharacterized protein	ISS	11027488	PubMed	PTHR24072:SF129	CDC42L PROTEIN
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	8011337	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04384	Gamma-aminobutyric acid synthesis	P04481	Succinic semialdehyde dehydrogenase	SCHPO|PomBase=SPAC139.05|UniProtKB=Q9UTM8	Putative succinate-semialdehyde dehydrogenase C139.05 [NADP(+)]	IC	12891648	PubMed	PTHR43353:SF5	SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00059	p53 pathway	P04609	PI3K	CHICK|Ensembl=ENSGALG00000014786|UniProtKB=E1C8M4	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00047	PDGF signaling pathway	P01168	PI3K	ORNAN|Ensembl=ENSOANG00000003359|UniProtKB=F6VAQ8	Phosphatidylinositol 3-kinase	ISS	129387	gi	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00036	Interleukin signaling pathway	P00992	Receptor subunit alpha	HUMAN|HGNC=6019|UniProtKB=P08887	Interleukin-6 receptor subunit alpha	ISS			PTHR23036:SF98	INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA
P00050	Plasminogen activating cascade	P01262	pro-uPA	MOUSE|MGI=MGI=97611|UniProtKB=P06869	Urokinase-type plasminogen activator	IGI	12591758	PubMed	PTHR24264:SF38	UROKINASE-TYPE PLASMINOGEN ACTIVATOR
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	ORNAN|Ensembl=ENSOANG00000021004|UniProtKB=F7ERP8	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	3370672	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	DROME|FlyBase=FBgn0024846|UniProtKB=O61443	Mitogen-activated protein kinase 14B	IDA	10514528	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00052	TGF-beta signaling pathway	P01286	TGFbeta	HUMAN|HGNC=1071|UniProtKB=P12644	Bone morphogenetic protein 4	TAS	9759503	PubMed	PTHR11848:SF165	BONE MORPHOGENETIC PROTEIN 4
P00021	FGF signaling pathway	P00627	ERK1-2	ARATH|TAIR=AT1G59580|UniProtKB=Q39022	Mitogen-activated protein kinase 2	ISS			PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00012	Cadherin signaling pathway	P00462	Casein kinase II	DAPPU|EnsemblGenome=DAPPUDRAFT_305830|UniProtKB=E9GTE8	Casein kinase II subunit beta	ISS	10806215	PubMed	PTHR11740:SF0	CASEIN KINASE II SUBUNIT BETA
P00008	Axon guidance mediated by Slit/Robo	P00351	Cxcr4	BOVIN|Ensembl=ENSBTAG00000001060|UniProtKB=P25930	C-X-C chemokine receptor type 4	ISS	4503175	gi	PTHR10489:SF594	C-X-C CHEMOKINE RECEPTOR TYPE 4
P00056	VEGF signaling pathway	P01411	Ras	MACMU|Ensembl=ENSMMUG00000001977|UniProtKB=F6VGN0	GTPase NRas	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	SCHPO|PomBase=SPAC6G9.11|UniProtKB=Q92356	Synaptobrevin homolog 1	ISS			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	RAT|RGD=621535|UniProtKB=G3V9W8	Protein Cacna1f	ISS	15737619	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00005	Angiogenesis	P00243	Raf	MOUSE|MGI=MGI=88190|UniProtKB=P28028	Serine/threonine-protein kinase B-raf	ISS	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00018	EGF receptor signaling pathway	P00565	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IGI	10644715	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00036	Interleukin signaling pathway	P00983	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00047	PDGF signaling pathway	P01174	Rho	CAEEL|WormBase=WBGene00012203|UniProtKB=Q23130	Rho GTPase Activating protein	ISS			PTHR23176:SF0	RHO GTPASE-ACTIVATING PROTEIN 68F
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01226	CDCrel-1	BOVIN|Ensembl=ENSBTAG00000015368|UniProtKB=Q3T008	Septin 4	ISS			PTHR18884:SF71	SEPTIN-4
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	RAT|RGD=1591007|UniProtKB=D3ZLD6	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P05730	Endogenous cannabinoid signaling	P05748	mGluR	CANLF|Ensembl=ENSCAFG00000004381|UniProtKB=J9JH96	Uncharacterized protein	ISS	7476890	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	CHICK|Ensembl=ENSGALG00000007794|UniProtKB=A9YZQ5	Dopamine receptor 2 protein transcript variant 1	ISS	2137198	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00035	Interferon-gamma signaling pathway	P00956	SOCS	HUMAN|HGNC=16852|UniProtKB=O75159	Suppressor of cytokine signaling 5	TAS	22247722	PubMed	PTHR44282:SF3	SUPPRESSOR OF CYTOKINE SIGNALING 5
P00047	PDGF signaling pathway	P01162	MEK	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	176872	OMIM	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P06959	CCKR signaling map	P07121	MAP2K2	HUMAN|HGNC=6842|UniProtKB=P36507	Dual specificity mitogen-activated protein kinase kinase 2	RCA	16816139	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00034	Integrin signalling pathway	P00922	Collagen	HUMAN|HGNC=2193|UniProtKB=Q07092	Collagen alpha-1(XVI) chain	IDA	10778855	PubMed	PTHR24023:SF372	COLLAGEN ALPHA-1 XVI  CHAIN
P00034	Integrin signalling pathway	P00932	FAK	PANTR|Ensembl=ENSPTRG00000020624|UniProtKB=H2QWS1	Uncharacterized protein	ISS	12640026	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	CAEEL|WormBase=WBGene00002173|UniProtKB=Q9Y0A1	Inositol 1,4,5-trisphosphate receptor itr-1	ISS	9065779	PubMed	PTHR13715:SF87	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
P05731	GABA-B receptor II signaling	P05754	Ggamma	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	RCA	2122451	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00055	Transcription regulation by bZIP transcription factor	P01399	TBP	DROME|FlyBase=FBgn0010287|UniProtKB=Q27896	TBP-related factor	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	LEIMA|EnsemblGenome=LmjF.35.3960|UniProtKB=E9AFM1	Protein kinase A catalytic subunit isoform 2	IC	10553940	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	TAS	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	HUMAN|HGNC=4039|UniProtKB=Q9ULW2	Frizzled-10	TAS	8717036	PubMed	PTHR11309:SF86	FRIZZLED-10
P00005	Angiogenesis	P00203	Erk	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9836512	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	MOUSE|MGI=MGI=97600|UniProtKB=P23298	Protein kinase C eta type	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IDA	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04374	5HT2 type receptor mediated signaling pathway	P04414	5HT2 Receptor	BOVIN|Ensembl=ENSBTAG00000039772|UniProtKB=F6QI78	Uncharacterized protein	ISS	12181435	PubMed	PTHR24247:SF31	5-HYDROXYTRYPTAMINE RECEPTOR 2B
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	ISS	1482697	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	BOVIN|Gene=VAMP3|UniProtKB=Q2KJD2	Vesicle-associated membrane protein 3	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	PANTR|Ensembl=ENSPTRG00000010585|UniProtKB=H2QFK0	Uncharacterized protein	ISS	6087160	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	DROME|FlyBase=FBgn0011300|UniProtKB=A1Z7L8	Receptor protein serine/threonine kinase	TAS	9395284	PubMed	PTHR23255:SF71	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00029	Huntington disease	P00796	Kainate receptor	HUMAN|HGNC=4579|UniProtKB=P39086	Glutamate receptor ionotropic, kainate 1	IDA	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00057	Wnt signaling pathway	P01444	Wnt	MOUSE|MGI=MGI=109485|UniProtKB=Q9WUD6	Protein Wnt-8b	IDA	11266476	PubMed	PTHR12027:SF94	PROTEIN WNT-8B
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	TRYB2|Gene=Tb11.v4.0007|UniProtKB=Q382Q0	Ribonucleoside-diphosphate reductase small chain	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P02772	Pyruvate metabolism	P03132	Pyruvate Kinase	MYCTU|EnsemblGenome=Rv1617|UniProtKB=P9WKE5	Pyruvate kinase	ISS	9634230	PubMed	PTHR11817:SF3	AT14039P-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	PANTR|Ensembl=ENSPTRG00000008727|UniProtKB=H2RCB8	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P02761	Pantothenate biosynthesis	P03069	2-Dehydropantoate reductase	RHOBA|EnsemblGenome=RB3312|UniProtKB=Q7UUG2	2-dehydropantoate 2-reductase	ISS			PTHR21708:SF26	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	HUMAN|HGNC=16059|UniProtKB=O96013	Serine/threonine-protein kinase PAK 4	ISS			PTHR24361:SF345	SERINE/THREONINE-PROTEIN KINASE PAK 4
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P06213	DPP signaling pathway	P06277	PUT	DROME|Gene=Dmel_CG7904|UniProtKB=A0A0B4KG59	Serine/threonine-protein kinase receptor	IEA	http://flybase.org/reports/FBgn0003169.html	Website	PTHR23255:SF70	SERINE/THREONINE-PROTEIN KINASE RECEPTOR
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00021	FGF signaling pathway	P00632	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01300	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	20843630	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00013	Cell cycle	P00480	Proteasome	RAT|RGD=621109|UniProtKB=O88321	Antisecretory factor	ISS	10505793	PubMed	PTHR10223:SF0	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4
P00018	EGF receptor signaling pathway	P00562	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IGI	10851062	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05916	Opioid prodynorphin pathway	P06002	G-protein	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IGI	3755548	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	MONDO|Ensembl=ENSMODG00000023940|UniProtKB=F6RFW8	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P02746	Heme biosynthesis	P02981	Glutamate-1-semialdehyde aminotransferase	METJA|EnsemblGenome=MJ_0603|UniProtKB=Q58020	Glutamate-1-semialdehyde 2,1-aminomutase	ISS			PTHR43713:SF3	GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE
P04393	Ras Pathway	P04567	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00634	MEKK1-5	RAT|RGD=1304575|UniProtKB=B5DF98	Map3k3 protein	ISS	9006902	PubMed	PTHR24361:SF610	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3
P00034	Integrin signalling pathway	P00916	Ras	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g247341|UniProtKB=A7STP5	Predicted protein	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P05734	Synaptic vesicle trafficking	P05778	SNAP-25	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	TAS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00005	Angiogenesis	P00223	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05915	Opioid proenkephalin pathway	P05989	leu-Enkephalin	HUMAN|HGNC=8831|UniProtKB=P01210	Proenkephalin-A	ISS	2990950	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P04398	p53 pathway feedback loops 2	P04665	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00786	ARF	HUMAN|HGNC=654|UniProtKB=P61204	ADP-ribosylation factor 3	IPI	12932731	PubMed	PTHR11711:SF294	ADP-RIBOSYLATION FACTOR 3
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	MACMU|Ensembl=ENSMMUG00000010173|UniProtKB=F7AGU8	Presenilin	ISS	12821663	PubMed	PTHR10202:SF18	PRESENILIN-1
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	EMENI|EnsemblGenome=CADANIAG00006296|UniProtKB=Q5ASG1	Putative synaptobrevin homologue SNC1/2 (Eurofung)	ISS			PTHR21136:SF4	VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
P06587	Nicotine pharmacodynamics pathway	P06608	DDC	MACMU|Ensembl=ENSMMUG00000019991|UniProtKB=F7FNW0	Aromatic-L-amino-acid decarboxylase	ISS	107930	OMIM	PTHR11999:SF138	AROMATIC-L-AMINO-ACID DECARBOXYLASE
P02773	S-adenosylmethionine biosynthesis	P03143	S-Adenosyl methionine synthetase	NEUCR|EnsemblGenome=EFNCRG00000002175|UniProtKB=P48466	S-adenosylmethionine synthase	ISS			PTHR11964:SF1	S-ADENOSYLMETHIONINE SYNTHASE
P00008	Axon guidance mediated by Slit/Robo	P00349	Cdc42	CANLF|Ensembl=ENSCAFG00000014707|UniProtKB=P60952	Cell division control protein 42 homolog	ISS	11027488	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00053	T cell activation	P01307	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	7478553	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00036	Interleukin signaling pathway	P00981	SOS	RAT|RGD=620435|UniProtKB=F1MAI3	Protein Sos2	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00009	Axon guidance mediated by netrin	P00356	UNC-5	CANLF|Ensembl=ENSCAFG00000010215|UniProtKB=F1PUV2	Uncharacterized protein	ISS			PTHR12582:SF7	NETRIN RECEPTOR UNC5C
P00005	Angiogenesis	P00254	GTPase	MONDO|Ensembl=ENSMODG00000000981|UniProtKB=F7ES59	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00851	NFAT	RAT|RGD=1310749|UniProtKB=D3Z9H7	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	ISS	9462517	PubMed	PTHR12533:SF11	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	14744463	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	11067767	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00054	Toll receptor signaling pathway	P01375	JNK	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00021	FGF signaling pathway	P00624	14-3-3	ARATH|TAIR=AT1G78220|UniProtKB=F4IA59	General regulatory factor 13	ISS			PTHR18860:SF32	14-3-3 FAMILY PROTEIN-RELATED
P00037	Ionotropic glutamate receptor pathway	P01019	AMPA	TAKRU|Ensembl=ENSTRUG00000011517|UniProtKB=H2TWL9	Uncharacterized protein (Fragment)	ISS	12941441	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P00049	Parkinson disease	P01219	SAPK	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	NAS	12040174	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00029	Huntington disease	P00786	ARF	HUMAN|HGNC=698|UniProtKB=P56559	ADP-ribosylation factor-like protein 4C	IPI	12932731	PubMed	PTHR11711:SF119	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 4C
P00012	Cadherin signaling pathway	P00471	Cadherin	CHICK|Gene=CDH4|UniProtKB=P24503	Cadherin-4	IDA	8120095	PubMed	PTHR24027:SF81	CADHERIN-4
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MOUSE|MGI=MGI=104778|UniProtKB=P51432	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00035	Interferon-gamma signaling pathway	P00953	Jak1	RAT|RGD=69056|UniProtKB=G3V9W2	Tyrosine-protein kinase	ISS	11929133	PubMed	PTHR24418:SF68	TYROSINE-PROTEIN KINASE JAK1
P02742	Tetrahydrofolate biosynthesis	P02944	Phosphoribosylglycinamide formyltransferase	PYRAE|EnsemblGenome=PAE0219|UniProtKB=Q8ZZK2	Phosphoribosylglycinamide formyltransferase	ISS			PTHR43369:SF2	PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE
P00057	Wnt signaling pathway	P01465	Ggamma	PANTR|Ensembl=ENSPTRG00000028220|UniProtKB=H2R4L6	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF31	SUBFAMILY NOT NAMED
P02738	De novo purine biosynthesis	P02899	GMP synthase	MOUSE|MGI=MGI=2448526|UniProtKB=Q3THK7	GMP synthase [glutamine-hydrolyzing]	ISS			PTHR11922:SF2	GMP SYNTHASE  GLUTAMINE-HYDROLYZING
P00041	Metabotropic glutamate receptor group I pathway	P01058	Homer	CANLF|Ensembl=ENSCAFG00000009074|UniProtKB=E2RT37	Uncharacterized protein	ISS	12653978	PubMed	PTHR10918:SF3	HOMER PROTEIN HOMOLOG 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05916	Opioid prodynorphin pathway	P06002	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	TAS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00050	Plasminogen activating cascade	P01250	MMP-13	PANTR|Ensembl=ENSPTRG00000004222|UniProtKB=H2Q4N4	Uncharacterized protein	ISS	98180967	PubMed	PTHR10201:SF165	COLLAGENASE 3
P05916	Opioid prodynorphin pathway	P06002	G-protein	DANRE|ZFIN=ZDB-GENE-040426-2280|UniProtKB=Q6P025	Gnb3 protein	ISS			PTHR19850:SF35	GNB3 PROTEIN
P00012	Cadherin signaling pathway	P00470	F-actin	ORYSJ|EnsemblGenome=OS11G0163100|UniProtKB=Q67G20	Actin	IC	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04384	Gamma-aminobutyric acid synthesis	P04480	GABA aminotransferase	PANTR|Ensembl=ENSPTRG00000007746|UniProtKB=H2QAJ4	4-aminobutyrate aminotransferase	ISS	8133261	PubMed	PTHR43206:SF1	4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05917	Opioid proopiomelanocortin pathway	P06004	Mu or Delta receptor	MOUSE|MGI=MGI=97441|UniProtKB=P42866	Mu-type opioid receptor	ISS	12093103	PubMed	PTHR24229:SF7	MU-TYPE OPIOID RECEPTOR
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05942	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04393	Ras Pathway	P04544	Grb2	PANTR|Ensembl=ENSPTRG00000009642|UniProtKB=G2HGD2	Growth factor receptor-bound protein 2	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00021	FGF signaling pathway	P00638	PLCgamma	MOUSE|MGI=MGI=97616|UniProtKB=Q8CIH5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	ISS	10925250	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00005	Angiogenesis	P00212	EphR	CHICK|Gene=EPHB1|UniProtKB=Q07494	Ephrin type-B receptor 1 (Fragment)	RCA			PTHR24416:SF173	EPHRIN TYPE-B RECEPTOR 1
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	11032873	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	15313841	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05730	Endogenous cannabinoid signaling	P05751	Galpha	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04377	Beta1 adrenergic receptor signaling pathway	P04439	AC	MONDO|Ensembl=ENSMODG00000002081|UniProtKB=F6V001	Uncharacterized protein	ISS	1719547	PubMed	PTHR11920:SF253	ADENYLATE CYCLASE TYPE 2
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8971|UniProtKB=O00443	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	ISS	7937853	PubMed	PTHR10048:SF28	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	ARATH|TAIR=AT3G59790|UniProtKB=Q9M1Z5	Mitogen-activated protein kinase 10	TAS			PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P00030	Hypoxia response via HIF activation	P00814	P300	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	9865691	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4405|UniProtKB=P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	IC	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P04393	Ras Pathway	P04564	MAPKAP	XENTR|Xenbase=XB-GENE-5896875|UniProtKB=F7CQI0	Uncharacterized protein	ISS			PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MONDO|Ensembl=ENSMODG00000021303|UniProtKB=F7G3J2	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00019	Endothelin signaling pathway	P00568	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05913	Enkephalin release	P05974	G-Protein (i)	CIOIN|Ensembl=ENSCING00000005305|UniProtKB=Q8WSS1	G protein alpha subunit Gi splicing variant CiGi1b	IC	10188796	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P00020	FAS signaling pathway	P00620	CytochromeC	CAEBR|Gene=CBG08212|UniProtKB=A8X623	Protein CBR-CYC-1	ISS	15163634	PubMed	PTHR10266:SF3	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	3045562	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00001	Adrenaline and noradrenaline biosynthesis	P00071	VAT1	RAT|RGD=3694|UniProtKB=Q01827	Synaptic vesicular amine transporter	ISS			PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	ANOGA|EnsemblGenome=AGAP004940|UniProtKB=Q7PPI8	AGAP004940-PA	IC	176910	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00029	Huntington disease	P00807	Actin	DAPPU|EnsemblGenome=DAPPUDRAFT_347736|UniProtKB=E9FRT1	Muscle-specific actin	ISS	11889126	PubMed	PTHR11937:SF162	ACTIN, LARVAL MUSCLE-RELATED
P00054	Toll receptor signaling pathway	P01358	ERK1	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04393	Ras Pathway	P04567	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00006	Apoptosis signaling pathway	P00269	MAPK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	10755300	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04393	Ras Pathway	P04570	AKT	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05913	Enkephalin release	P05974	G-Protein (i)	MACMU|Ensembl=ENSMMUG00000023424|UniProtKB=F7F580	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF31	SUBFAMILY NOT NAMED
P00046	Oxidative stress response	P01133	Max	CANLF|Ensembl=ENSCAFG00000016212|UniProtKB=E2QZS2	Uncharacterized protein	ISS	11274345	PubMed	PTHR10328:SF3	PROTEIN MAX
P00015	Circadian clock system	G01497	cry	MOUSE|MGI=MGI=1270859|UniProtKB=Q9R194	Cryptochrome-2	IDA	10217146	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00018	EGF receptor signaling pathway	P00547	PP2A	SCHMA|EnsemblGenome=Smp_165490|UniProtKB=C1LZY9	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	BOVIN|Ensembl=ENSBTAG00000014119|UniProtKB=A0JNH7	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00029	Huntington disease	P00805	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01177	P110ACT	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00029	Huntington disease	P00778	NMDA receptor	MONDO|Ensembl=ENSMODG00000018204|UniProtKB=F6PGX6	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P05734	Synaptic vesicle trafficking	P05769	Synaptotagmin	MONDO|Ensembl=ENSMODG00000000628|UniProtKB=F6TAG2	Uncharacterized protein	ISS			PTHR10024:SF45	SYNAPTOTAGMIN-6
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	IC	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P02742	Tetrahydrofolate biosynthesis	P02941	Dihydroneopterin aldolase	ARATH|TAIR=AT3G11750|UniProtKB=Q9SF23	Dihydroneopterin aldolase 1	ISS			PTHR42844:SF4	DIHYDRONEOPTERIN ALDOLASE 1-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	CANLF|Ensembl=ENSCAFG00000011335|UniProtKB=E2R2S8	Uncharacterized protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MACMU|Ensembl=ENSMMUG00000016840|UniProtKB=F7C389	Dual specificity mitogen-activated protein kinase kinase 1	ISS	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04398	p53 pathway feedback loops 2	P04665	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	12655147	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05918	p38 MAPK pathway	P05919	MAPKAP-K3	BOVIN|Ensembl=ENSBTAG00000016532|UniProtKB=Q3SYZ2	MAP kinase-activated protein kinase 3	ISS	11335727	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01080	AChE	HUMAN|HGNC=108|UniProtKB=P22303	Acetylcholinesterase	IC			PTHR11559:SF356	ACETYLCHOLINESTERASE
P00023	General transcription regulation	P00668	TFIIB	CANLF|Ensembl=ENSCAFG00000020209|UniProtKB=E2RPG1	Uncharacterized protein	ISS			PTHR11618:SF13	TRANSCRIPTION INITIATION FACTOR IIB
P00021	FGF signaling pathway	P00623	FGF	HUMAN|HGNC=3667|UniProtKB=Q92914	Fibroblast growth factor 11	ISS			PTHR11486:SF67	FIBROBLAST GROWTH FACTOR 11
P00006	Apoptosis signaling pathway	P00321	HSP70	CANLF|Ensembl=ENSCAFG00000020196|UniProtKB=F1PIC7	Uncharacterized protein	ISS	10934466	PubMed	PTHR19375:SF144	78 KDA GLUCOSE-REGULATED PROTEIN
P00006	Apoptosis signaling pathway	P00322	Cytochrome C	ARATH|TAIR=AT1G22840|UniProtKB=O23138	Cytochrome c-1	ISS	117959	gi	PTHR11961:SF9	CYTOCHROME C-1-RELATED
P00029	Huntington disease	P00797	p53	TAKRU|Ensembl=ENSTRUG00000003384|UniProtKB=H2S6A7	Uncharacterized protein	ISS			PTHR12195:SF1	CYTOPLASMIC FMR1-INTERACTING PROTEIN 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	ANOGA|EnsemblGenome=AGAP001936|UniProtKB=F5HMB9	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00715	AGS3	MONDO|Ensembl=ENSMODG00000002268|UniProtKB=F7CVY1	Uncharacterized protein	ISS	11121039	PubMed	PTHR10098:SF100	G-PROTEIN-SIGNALING MODULATOR 2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BOVIN|Ensembl=ENSBTAG00000006189|UniProtKB=P63258	Actin, cytoplasmic 2	ISS	11889126	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	11067767	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC	3100519	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MOUSE|MGI=MGI=95775|UniProtKB=P18872	Guanine nucleotide-binding protein G(o) subunit alpha	RCA			PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00045	Notch signaling pathway	P01105	TACE	BOVIN|Ensembl=ENSBTAG00000001141|UniProtKB=G3MZB3	Uncharacterized protein	ISS	9774383	PubMed	PTHR11905:SF171	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17
P00013	Cell cycle	P00480	Proteasome	MACMU|Ensembl=ENSMMUG00000002132|UniProtKB=F6UPJ2	26S proteasome non-ATPase regulatory subunit 12 isoform 1	ISS	9426256	PubMed	PTHR10855:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12
P04387	Histamine synthesis	P04493	Histidine decarboxylase	RAT|RGD=2790|UniProtKB=P16453	Histidine decarboxylase	ISS	1702422	PubMed	PTHR11999:SF68	HISTIDINE DECARBOXYLASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DANRE|ZFIN=ZDB-GENE-030131-172|UniProtKB=Q6IQR3	Actin, alpha, cardiac muscle 1a	IC	11889126	PubMed	PTHR11937:SF238	ACTIN, ALPHA, CARDIAC MUSCLE 1A
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	TAKRU|Ensembl=ENSTRUG00000007253|UniProtKB=H2SZQ1	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT4G01370|UniProtKB=Q39024	Mitogen-activated protein kinase 4	ISS	12787066	PubMed	PTHR24055:SF227	MITOGEN-ACTIVATED PROTEIN KINASE 11-RELATED
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=12780|UniProtKB=P09544	Protein Wnt-2	IDA	11266476	PubMed	PTHR12027:SF86	PROTEIN WNT-2
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000008751|UniProtKB=H2QC89	Uncharacterized protein	ISS	129387	gi	PTHR15593:SF2	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MOUSE|MGI=MGI=97760|UniProtKB=P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	2254332	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P02770	Pyridoxal phosphate salvage pathway	P03120	Pyridoxamine-5-phosphate oxidase	PANTR|Ensembl=ENSPTRG00000009343|UniProtKB=H2QDB2	Pyridoxamine 5'-phosphate oxidase	ISS	9601034	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P04393	Ras Pathway	P04556	Raf	MOUSE|MGI=MGI=97847|UniProtKB=Q99N57	RAF proto-oncogene serine/threonine-protein kinase	IDA	Q99N57	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	CHICK|Ensembl=ENSGALG00000015835|UniProtKB=F1NZT2	Uncharacterized protein	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MACMU|Ensembl=ENSMMUG00000004886|UniProtKB=F7AGT9	Uncharacterized protein	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DROME|FlyBase=FBgn0011288|UniProtKB=P36975	Synaptosomal-associated protein 25	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00005	Angiogenesis	P00219	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	CANLF|Ensembl=ENSCAFG00000010595|UniProtKB=F1PUM1	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF43	REGULATOR OF G-PROTEIN SIGNALING 2
P00010	B cell activation	P00385	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	10644715	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P05918	p38 MAPK pathway	P06026	MEKK4	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS	12052864	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P05731	GABA-B receptor II signaling	P05757	Gi/oalpha	HUMAN|HGNC=4389|UniProtKB=P09471	Guanine nucleotide-binding protein G(o) subunit alpha	RCA	15860573	PubMed	PTHR10218:SF293	GUANINE NUCLEOTIDE-BINDING PROTEIN G O  SUBUNIT ALPHA
P00025	Hedgehog signaling pathway	P00692	GSK3	CHICK|Ensembl=ENSGALG00000014977|UniProtKB=F1NPL8	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00018	EGF receptor signaling pathway	P00547	PP2A	HUMAN|HGNC=9300|UniProtKB=P62714	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	IGI	10698523	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00570	PKA	CAEEL|WormBase=WBGene00002190|UniProtKB=P30625	cAMP-dependent protein kinase regulatory subunit	IDA	2303451	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00056	VEGF signaling pathway	P01425	PKC	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00034	Integrin signalling pathway	P00927	Rac	DICDI|dictyBase=DDB_G0279605|UniProtKB=P34148	Rho-related protein racB	IGI	12932731	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00019	Endothelin signaling pathway	P00570	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00056	VEGF signaling pathway	P01413	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	DANRE|ZFIN=ZDB-GENE-030131-8013|UniProtKB=F1QBT6	Uncharacterized protein	ISS	12497607	PubMed	PTHR18966:SF100	GLUTAMATE RECEPTOR 4
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	14570579	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	IC	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00012	Cadherin signaling pathway	P00470	F-actin	DROME|FlyBase=FBgn0000047|UniProtKB=P83967	Actin, indirect flight muscle	IC	14684598	PubMed	PTHR11937:SF368	ACTIN, INDIRECT FLIGHT MUSCLE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00048	PI3 kinase pathway	P01185	SOS	CANLF|Ensembl=ENSCAFG00000014275|UniProtKB=F1P859	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01064	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	4262086	gi	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	10414292	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00029	Huntington disease	P00786	ARF	CAEBR|Gene=CBG00557|UniProtKB=A8WNL4	Protein CBR-ARL-1	ISS	12932731	PubMed	PTHR11711:SF41	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	XENTR|Xenbase=XB-GENE-494548|UniProtKB=F7EC26	Uncharacterized protein	ISS	20362513	PubMed	PTHR24070:SF186	GTPASE KRAS
P00005	Angiogenesis	P00238	Ras	PANTR|Ensembl=ENSPTRG00000034469|UniProtKB=H2Q2V0	Uncharacterized protein	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ORYSJ|EnsemblGenome=OS02G0148100|UniProtKB=Q6Z437	Mitogen-activated protein kinase 3	ISS	10851062	PubMed	PTHR24055:SF216	SUBFAMILY NOT NAMED
P00054	Toll receptor signaling pathway	P01338	IkappaB	CHICK|Gene=NFKBIA|UniProtKB=Q91974	NF-kappa-B inhibitor alpha	ISS	10811867	PubMed	PTHR24139:SF36	NF-KAPPA-B INHIBITOR ALPHA
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	3045562	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02738	De novo purine biosynthesis	P02901	Adenosuccinate lyase	ANOGA|EnsemblGenome=AGAP002378|UniProtKB=Q7QBZ6	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P00004	Alzheimer disease-presenilin pathway	P00168	E-cadherin intracellular fragment	HUMAN|HGNC=1762|UniProtKB=P22223	Cadherin-3	IDA	12834808	PubMed	PTHR24027:SF267	CADHERIN-3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00045	Notch signaling pathway	P01103	Next	MOUSE|MGI=MGI=97364|UniProtKB=O35516	Neurogenic locus notch homolog protein 2	ISS	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	MACMU|Ensembl=ENSMMUG00000022513|UniProtKB=F6YNZ0	Uncharacterized protein	ISS	20012997	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00021	FGF signaling pathway	P00625	MKK3,6	XENTR|Xenbase=XB-GENE-944183|UniProtKB=F7EJU0	Uncharacterized protein (Fragment)	RCA			PTHR24361:SF645	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00522	Myosin	PANTR|Ensembl=ENSPTRG00000014309|UniProtKB=H2QLK6	Uncharacterized protein	ISS			PTHR13140:SF317	MYOSIN-9
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	ORNAN|Ensembl=ENSOANG00000002969|UniProtKB=F6V461	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	YEAST|SGD=S000001855|UniProtKB=P60010	Actin	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	RAT|RGD=61880|UniProtKB=P63025	Vesicle-associated membrane protein 3	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00019	Endothelin signaling pathway	P00587	Raf-1	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	RAT|RGD=3784|UniProtKB=P61265	Syntaxin-1B	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	15572354	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P02738	De novo purine biosynthesis	P02906	N5-carboxyaminoimidazole ribonucleotide synthase	BACSU|EnsemblGenome=BSU06420|UniProtKB=P12044	N5-carboxyaminoimidazole ribonucleotide mutase	ISS			PTHR23046:SF2	N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE MUTASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	IDA	8787761	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00977	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	ISS	8409414	PubMed	PTHR24070:SF189	GTPASE NRAS
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	BOVIN|Ensembl=ENSBTAG00000012510|UniProtKB=E1BHX7	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04393	Ras Pathway	P04572	JNK	TAKRU|Ensembl=ENSTRUG00000013056|UniProtKB=H2U861	Mitogen-activated protein kinase	ISS	2507197	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00039	Metabotropic glutamate receptor group III pathway	P01045	G-Protein	DANRE|ZFIN=ZDB-GENE-030131-2229|UniProtKB=Q7ZW82	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	P01440	Cadherin	BOVIN|Ensembl=ENSBTAG00000032092|UniProtKB=A2VDQ6	Cadherin 11, type 2, OB-cadherin (Osteoblast)	ISS	8120095	PubMed	PTHR24027:SF85	CADHERIN-11
P00018	EGF receptor signaling pathway	P00543	ERK1-2	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00037	Ionotropic glutamate receptor pathway	P01022	Ca2+ channel	HUMAN|HGNC=1389|UniProtKB=Q00975	Voltage-dependent N-type calcium channel subunit alpha-1B	ISS	15079861	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	176892	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00477	GSK3beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00021	FGF signaling pathway	P00633	Ras	CHICK|Ensembl=ENSGALG00000006885|UniProtKB=P08642	GTPase HRas	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	11642544	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	10747026	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DROME|FlyBase=FBgn0010333|UniProtKB=P40792	Ras-related protein Rac1	ISS	8649368	PubMed	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02738	De novo purine biosynthesis	P02892	5-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase	THEMA|EnsemblGenome=TM_1095|UniProtKB=Q9X0I0	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P00005	Angiogenesis	P00219	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	2837282	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	IC	93386758	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	DANRE|ZFIN=ZDB-GENE-050116-2|UniProtKB=Q5I0F6	Prkar1a protein	ISS	188830	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00249	PAK	HUMAN|HGNC=8590|UniProtKB=Q13153	Serine/threonine-protein kinase PAK 1	IDA	11689432	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00020	FAS signaling pathway	P00601	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P05918	p38 MAPK pathway	P06031	p38alpha	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	ISS	20451058	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	RAT|RGD=619749|UniProtKB=Q9JID2	Guanine nucleotide-binding protein subunit alpha-11	ISS	8836152	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00036	Interleukin signaling pathway	P00973	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	TAS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05918	p38 MAPK pathway	P06031	p38alpha	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	RCA	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00045	Notch signaling pathway	P01104	Serrate	DANRE|ZFIN=ZDB-GENE-011128-2|UniProtKB=Q90Y57	Protein jagged-1a	ISS			PTHR44097:SF3	PROTEIN JAGGED-1
P00005	Angiogenesis	P00191	TF	PANTR|Ensembl=ENSPTRG00000000977|UniProtKB=H2R022	Tissue factor	ISS	8779717	PubMed	PTHR20859:SF22	TISSUE FACTOR
P00004	Alzheimer disease-presenilin pathway	P00114	actin	PRIPA|Gene=PPA23459|UniProtKB=H3FMF2	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00018	EGF receptor signaling pathway	P00547	PP2A	RAT|RGD=6503746|UniProtKB=Q80W83	Protein LOC100909468	ISS	11531413	PubMed	PTHR10257:SF4	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00648	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00005	Angiogenesis	P00244	MAPKAPK2/3	RAT|RGD=1304980|UniProtKB=Q66H84	MAP kinase-activated protein kinase 3	ISS	11335727	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	CANLF|Ensembl=ENSCAFG00000014643|UniProtKB=E2RJB3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P00036	Interleukin signaling pathway	P00996	STAT	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	15825084	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	IDA	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P06587	Nicotine pharmacodynamics pathway	P06609	GNAI	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	1482697	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P04393	Ras Pathway	P04572	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00187	beta catenin	MOUSE|MGI=MGI=88276|UniProtKB=Q02248	Catenin beta-1	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00004	Alzheimer disease-presenilin pathway	P00111	C99	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	6375662	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00029	Huntington disease	P00790	beta-Tubulin	BRAFL|Gene=BRAFLDRAFT_60807|UniProtKB=C3Y2F5	Putative uncharacterized protein	ISS	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00056	VEGF signaling pathway	P01407	Erk	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00564	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	8649368	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P05730	Endogenous cannabinoid signaling	P05751	Galpha	HUMAN|HGNC=4384|UniProtKB=P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	RCA	12488551	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00053	T cell activation	P01311	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12639709	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00807	Actin	CANLF|Ensembl=ENSCAFG00000008756|UniProtKB=F2Z4N8	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00004	Alzheimer disease-presenilin pathway	P00123	CD44 C-terminal fragment	CHICK|Ensembl=ENSGALG00000007849|UniProtKB=F1NL98	Uncharacterized protein	IDA	12223485	PubMed	PTHR10225:SF6	CD44 ANTIGEN
P00006	Apoptosis signaling pathway	P00301	Apaf-1	BOVIN|Ensembl=ENSBTAG00000021661|UniProtKB=F1MUW4	Apoptotic protease-activating factor 1	ISS	14526190	PubMed	PTHR22845:SF5	APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
P00018	EGF receptor signaling pathway	P00563	Gab	RAT|RGD=1311085|UniProtKB=A0A0G2JZD5	Protein Gab1	ISS	20885508	gi	PTHR12156:SF18	GRB2-ASSOCIATED-BINDING PROTEIN 1
P00006	Apoptosis signaling pathway	P00274	JNK	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9393873	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00056	VEGF signaling pathway	P01419	Ets	MACMU|Ensembl=ENSMMUG00000020706|UniProtKB=F6PU72	Uncharacterized protein	ISS	9157999	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=24667|UniProtKB=Q8TD08	Mitogen-activated protein kinase 15	ISS	11875070	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P05913	Enkephalin release	P05972	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00048	PI3 kinase pathway	P01198	FOXO	HUMAN|HGNC=7139|UniProtKB=P98177	Forkhead box protein O4	ISS			PTHR11829:SF188	FORKHEAD BOX PROTEIN O4
P00016	Cytoskeletal regulation by Rho GTPase	P00521	Profilin	DICDI|dictyBase=DDB_G0287125|UniProtKB=P26199	Profilin-1	ISS			PTHR11604:SF19	PROFILIN-1
P00057	Wnt signaling pathway	P01455	Smad4	XENTR|Xenbase=XB-GENE-485691|UniProtKB=F7BDU6	Mothers against decapentaplegic homolog (Fragment)	ISS	10693808	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	TAS	11707292	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00715	AGS3	MOUSE|MGI=MGI=1915089|UniProtKB=Q6IR34	G-protein-signaling modulator 1	IDA	11121039	PubMed	PTHR10098:SF36	G-PROTEIN-SIGNALING MODULATOR 1
P00053	T cell activation	P01298	NFkappaB	MOUSE|MGI=MGI=1099800|UniProtKB=Q9WTK5	Nuclear factor NF-kappa-B p100 subunit	IGI	20151924	PubMed	PTHR24169:SF21	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	RCA	9754712	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00053	T cell activation	P01322	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00548	RKIP	NEUCR|EnsemblGenome=EFNCRG00000004275|UniProtKB=Q1K771	Lipid binding protein	ISS			PTHR11362:SF74	SUBFAMILY NOT NAMED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04588	Thyrotropin	MACMU|Ensembl=ENSMMUG00000009962|UniProtKB=F6RBM2	Thyroid stimulating hormone beta subunit	ISS	15927770	PubMed	PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P00022	General transcription by RNA polymerase I	P00650	TAF-IB	MOUSE|MGI=MGI=1926879|UniProtKB=Q9EQH4	Transcription initiation factor TFIID subunit 8	ISS			PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00727	Gbeta	MACMU|Ensembl=ENSMMUG00000004083|UniProtKB=F6ZIZ9	Guanine nucleotide-binding protein subunit beta-4	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00059	p53 pathway	P04626	GADD45	MOUSE|MGI=MGI=107799|UniProtKB=P48316	Growth arrest and DNA damage-inducible protein GADD45 alpha	IGI	7509226	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ORYSJ|EnsemblGenome=OS03G0718100|UniProtKB=Q10DV7	Actin-1	IC	10974003	PubMed	PTHR11937:SF364	ACTIN-11
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04393	Ras Pathway	P04567	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	BOVIN|Ensembl=ENSBTAG00000034854|UniProtKB=F1N246	Uncharacterized protein	ISS	92224905	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PHYPA|Gene=PHYPADRAFT_172686|UniProtKB=A9TYG6	Predicted protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00712	Gialpha	BRAFL|Gene=BRAFLDRAFT_60318|UniProtKB=C3XY80	Gi alpha subunit	ISS	12488551	PubMed	PTHR10218:SF241	G PROTEIN ALPHA I SUBUNIT
P06213	DPP signaling pathway	P06288	MAD	DROME|FlyBase=FBgn0011648|UniProtKB=P42003	Protein mothers against dpp	IGI	9395284	PubMed	PTHR13703:SF40	PROTEIN MOTHERS AGAINST DPP
P00019	Endothelin signaling pathway	P00587	Raf-1	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12612072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P04375	5HT3 type receptor mediated signaling pathway	P04424	5HT vesicular transporter	MOUSE|MGI=MGI=106677|UniProtKB=Q8BRU6	Synaptic vesicular amine transporter	ISS	12135927	PubMed	PTHR23506:SF23	SYNAPTIC VESICULAR AMINE TRANSPORTER
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	XENTR|Xenbase=XB-GENE-494200|UniProtKB=F7CS79	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00047	PDGF signaling pathway	P01174	Rho	MACMU|Ensembl=ENSMMUG00000022614|UniProtKB=F6Z6L0	Uncharacterized protein	ISS			PTHR14166:SF6	SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 2-RELATED
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	15313841	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00023	General transcription regulation	P00662	TFIIA complex	MACMU|Ensembl=ENSMMUG00000018428|UniProtKB=F7HH39	Transcription initiation factor IIA subunit 2	ISS			PTHR10966:SF0	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2
P00052	TGF-beta signaling pathway	P01284	JNK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00057	Wnt signaling pathway	G01558	Wnt Target Genes	BOVIN|Ensembl=ENSBTAG00000010111|UniProtKB=F1MJS2	Uncharacterized protein	ISS	9118222	PubMed	PTHR10373:SF25	TRANSCRIPTION FACTOR 7-LIKE 1
P00011	Blood coagulation	P00458	GP IIIa	BOVIN|Ensembl=ENSBTAG00000009987|UniProtKB=F1MTN1	Integrin beta	ISS	5805343	gi	PTHR10082:SF25	INTEGRIN BETA-3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	TAKRU|Ensembl=ENSTRUG00000000699|UniProtKB=H2RNG1	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9395|UniProtKB=P05771	Protein kinase C beta type	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	MONDO|Ensembl=ENSMODG00000008180|UniProtKB=F7E4E2	Uncharacterized protein (Fragment)	ISS	89264452	PubMed	PTHR13140:SF328	MYOSIN-10
P00010	B cell activation	P00373	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	12667549	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000015241|UniProtKB=Q5IS72	D(3) dopamine receptor	ISS	11248120	PubMed	PTHR44250:SF3	D 3  DOPAMINE RECEPTOR
P05731	GABA-B receptor II signaling	P05752	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P02728	Arginine biosynthesis	P02840	Argininosuccinate synthase	MACMU|Ensembl=ENSMMUG00000019199|UniProtKB=F6QXP1	Uncharacterized protein	ISS			PTHR11587:SF2	ARGININOSUCCINATE SYNTHASE
P02740	De novo pyrimidine ribonucleotides biosythesis	P02927	Dihydrooratate oxidase	ANOGA|EnsemblGenome=AGAP002037|UniProtKB=Q7PYN9	Dihydroorotate dehydrogenase (quinone), mitochondrial	ISS			PTHR43517:SF1	DIHYDROOROTATE DEHYDROGENASE  QUINONE , MITOCHONDRIAL
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00728	RhoGEF	HUMAN|HGNC=681|UniProtKB=Q92888	Rho guanine nucleotide exchange factor 1	IDA	12123608	PubMed	PTHR12673:SF122	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 1
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=620961|UniProtKB=F1M7Y5	Protein kinase C iota type	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	MOUSE|MGI=MGI=95781|UniProtKB=P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00012	Cadherin signaling pathway	P00475	Frizzled	XENTR|Xenbase=XB-GENE-480800|UniProtKB=F6VM33	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF90	FRIZZLED-8
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	DANRE|ZFIN=ZDB-GENE-041121-9|UniProtKB=Q5RKP9	Uncharacterized protein	ISS	11254681	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00004	Alzheimer disease-presenilin pathway	P00125	Ire-1 C-terminal fragment	PANTR|Ensembl=ENSPTRG00000007893|UniProtKB=H2QAS4	Uncharacterized protein	ISS	10619423	PubMed	PTHR13954:SF15	SERINE/THREONINE-PROTEIN KINASE/ENDORIBONUCLEASE IRE2
P00034	Integrin signalling pathway	P00916	Ras	CAEBR|Gene=CBG06092|UniProtKB=A8X0X5	Protein CBR-LET-60	ISS	22022015	PubMed	PTHR24070:SF385	GTPASE HRAS
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	TAS	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00055	Transcription regulation by bZIP transcription factor	P01398	TFIIEalpha	PANTR|Ensembl=ENSPTRG00000015273|UniProtKB=H2QN66	General transcription factor IIE, polypeptide 1, alpha 56kDa	ISS	189962	OMIM	PTHR13097:SF6	GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MONDO|Ensembl=ENSMODG00000004415|UniProtKB=F6SD46	Phosphoinositide phospholipase C (Fragment)	ISS	1707501	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00010	B cell activation	P00371	ERK	PANTR|Ensembl=ENSPTRG00000007988|UniProtKB=H2RA86	Mitogen-activated protein kinase	ISS	601795	OMIM	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	9166716	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00053	T cell activation	P01322	PI3K	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00029	Huntington disease	P00807	Actin	XENTR|Xenbase=XB-GENE-488998|UniProtKB=Q5BL41	Actin-related protein 2	ISS	10974003	PubMed	PTHR11937:SF37	ACTIN-RELATED PROTEIN 2
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	HUMAN|HGNC=9059|UniProtKB=Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00006	Apoptosis signaling pathway	P00313	IKK	HUMAN|HGNC=5960|UniProtKB=O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01161	Raf	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00018	EGF receptor signaling pathway	P00560	Raf-1	CAEEL|WormBase=WBGene00003030|UniProtKB=Q07292	Raf homolog serine/threonine-protein kinase	ISS			PTHR44000:SF2	RAF HOMOLOG SERINE/THREONINE-PROTEIN KINASE PHL
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00888	P90 RSK	CHICK|Ensembl=ENSGALG00000016406|UniProtKB=F1NLJ3	Uncharacterized protein	ISS	10480933	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00018	EGF receptor signaling pathway	P00552	Ras	DICDI|dictyBase=DDB_G0292996|UniProtKB=P03967	Ras-like protein rasD	IGI	85024887	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00029	Huntington disease	P00807	Actin	HUMAN|HGNC=132|UniProtKB=P60709	Actin, cytoplasmic 1	IDA	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00029	Huntington disease	P00807	Actin	DICDI|dictyBase=DDB_G0269234|UniProtKB=P07830	Major actin	IDA	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00021	FGF signaling pathway	P00636	FGFR1-4	BOVIN|Ensembl=ENSBTAG00000010543|UniProtKB=F1MN51	Fibroblast growth factor receptor	ISS	93194827	PubMed	PTHR24416:SF343	FIBROBLAST GROWTH FACTOR RECEPTOR 4
P00004	Alzheimer disease-presenilin pathway	P00155	Presenilin C-terminal fragment	XENTR|Xenbase=XB-GENE-854877|UniProtKB=F7C949	Presenilin	ISS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00041	Metabotropic glutamate receptor group I pathway	P01056	IP3R	BOVIN|Gene=ITPR1|UniProtKB=Q9TU34	Inositol 1,4,5-trisphosphate receptor type 1	ISS	11007872	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00627	ERK1-2	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04377	Beta1 adrenergic receptor signaling pathway	P04435	SNARE Complex	CAEEL|WormBase=WBGene00019305|UniProtKB=P83351	Soluble NSF attachment protein 29	IC	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00005	Angiogenesis	P00238	Ras	BOVIN|Ensembl=ENSBTAG00000009778|UniProtKB=E1BMX0	Uncharacterized protein	ISS	3023884	PubMed	PTHR24070:SF186	GTPASE KRAS
P05912	Dopamine receptor mediated signaling pathway	P05965	D2/D3/D4	XENTR|Xenbase=XB-GENE-1005779|UniProtKB=F7E3I6	Uncharacterized protein	ISS	11248120	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00034	Integrin signalling pathway	P00951	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	BRAFL|Gene=BRAFLDRAFT_124869|UniProtKB=C3ZEW0	Putative uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF263	SUBFAMILY NOT NAMED
P00054	Toll receptor signaling pathway	P01365	TAB1	HUMAN|HGNC=18157|UniProtKB=Q15750	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1	ISS	8638164	PubMed	PTHR13832:SF533	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	HUMAN|HGNC=6182|UniProtKB=Q14573	Inositol 1,4,5-trisphosphate receptor type 3	ISS	4262086	gi	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00046	Oxidative stress response	P01129	JNK1/2	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04397	p53 pathway by glucose deprivation	P04641	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	IDA	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	15313841	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01451	Galpha	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00036	Interleukin signaling pathway	P00973	PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	14526383	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	MOUSE|MGI=MGI=1313276|UniProtKB=Q62442	Vesicle-associated membrane protein 1	ISS	14570579	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	MACMU|Ensembl=ENSMMUG00000014023|UniProtKB=F7AVT5	Uncharacterized protein	ISS	9783586	PubMed	PTHR10814:SF24	TRANSDUCIN-LIKE ENHANCER PROTEIN 3
P00011	Blood coagulation	P00406	Fibrinogen	PANTR|Ensembl=ENSPTRG00000016535|UniProtKB=H2QQB5	Uncharacterized protein	ISS	4503689	gi	PTHR19143:SF232	FIBRINOGEN ALPHA CHAIN
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00021	FGF signaling pathway	P00644	p38	CAEBR|Gene=CBG01555|UniProtKB=A8WRD7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00010	B cell activation	P00384	p38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	11274345	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P02738	De novo purine biosynthesis	P02889	dGDP kinase	NEUCR|EnsemblGenome=EFNCRG00000003892|UniProtKB=Q9UUY8	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P04398	p53 pathway feedback loops 2	P04657	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00012	Cadherin signaling pathway	P00470	F-actin	DANRE|ZFIN=ZDB-GENE-040625-35|UniProtKB=Q6IQL9	Novel actin protein	ISS	14684598	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00021	FGF signaling pathway	P00640	PI3K	ANOGA|EnsemblGenome=AGAP000018|UniProtKB=Q7QEJ7	AGAP000018-PA	ISS	1171954	gi	PTHR10048:SF14	PI-3 KINASE
P04393	Ras Pathway	P04553	PAK	CANLF|Ensembl=ENSCAFG00000004956|UniProtKB=E2REH3	Uncharacterized protein	ISS	12912914	PubMed	PTHR24361:SF232	SERINE/THREONINE-PROTEIN KINASE PAK 1
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	BOVIN|Ensembl=ENSBTAG00000011851|UniProtKB=A0JNB0	Tyrosine-protein kinase Fyn	ISS	9741627	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	XENTR|Xenbase=XB-GENE-5738634|UniProtKB=Q5I080	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	10704417	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00748	Gbeta5L	HUMAN|HGNC=4401|UniProtKB=O14775	Guanine nucleotide-binding protein subunit beta-5	IEA	11313908	PubMed	PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	HUMAN|HGNC=7597|UniProtKB=O00159	Unconventional myosin-Ic	IC			PTHR13140:SF255	UNCONVENTIONAL MYOSIN-IC
P00016	Cytoskeletal regulation by Rho GTPase	P00513	Op18/stathmin	HUMAN|HGNC=16078|UniProtKB=Q9H169	Stathmin-4	ISS			PTHR10104:SF6	STATHMIN-4
P06664	Gonadotropin-releasing hormone receptor pathway	P06819	SMAD2-4	MOUSE|MGI=MGI=1328787|UniProtKB=P97454	Mothers against decapentaplegic homolog 5	RCA	9395284	PubMed	PTHR13703:SF36	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5
P00003	Alzheimer disease-amyloid secretase pathway	P00080	AICD	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	DANRE|ZFIN=ZDB-GENE-040801-208|UniProtKB=Q6DBV8	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00047	PDGF signaling pathway	P01142	p90RSK	XENTR|Xenbase=XB-GENE-480947|UniProtKB=F6ZM17	Uncharacterized protein (Fragment)	ISS	6755374	gi	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P04393	Ras Pathway	P04572	JNK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	RAT|RGD=69277|UniProtKB=P25108	Acetylcholine receptor subunit alpha	IC	85270494	PubMed	PTHR18945:SF74	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA
P00005	Angiogenesis	P00252	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	4504111	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00030	Hypoxia response via HIF activation	P00819	AKT	TAKRU|Ensembl=ENSTRUG00000003633|UniProtKB=H2S7Z2	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	HUMAN|HGNC=1390|UniProtKB=Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00006	Apoptosis signaling pathway	P00260	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04395	Vasopressin synthesis	P04597	Signal Peptide	RAT|RGD=3238|UniProtKB=P01179	Oxytocin-neurophysin 1	ISS	192340	OMIM	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12719720	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01311	Raf	MONDO|Ensembl=ENSMODG00000006307|UniProtKB=F7BRK5	Uncharacterized protein	ISS	P05625	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00790	beta-Tubulin	MACMU|Ensembl=ENSMMUG00000008877|UniProtKB=F7DTM8	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	11554554	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02770	Pyridoxal phosphate salvage pathway	P03123	Pyridoxine-5-phosphate oxidase	BOVIN|Ensembl=ENSBTAG00000012259|UniProtKB=Q5E9K3	Pyridoxine-5'-phosphate oxidase	ISS	9601034	PubMed	PTHR10851:SF0	PYRIDOXINE-5'-PHOSPHATE OXIDASE
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Gene=PCDHB13|UniProtKB=Q5DRD6	Protocadherin beta-13	ISS	8120095	PubMed	PTHR24028:SF61	PROTOCADHERIN BETA-13
P00003	Alzheimer disease-amyloid secretase pathway	P00102	Presenilin C-terminal fragment	MACMU|Ensembl=ENSMMUG00000018525|UniProtKB=F7A2D1	Presenilin	ISS	8755489	PubMed	PTHR10202:SF13	PRESENILIN-2
P00037	Ionotropic glutamate receptor pathway	P01023	CaMKII	BOVIN|Ensembl=ENSBTAG00000020087|UniProtKB=Q08E45	Calcium/calmodulin-dependent protein kinase II alpha	ISS	10092204	PubMed	PTHR43940:SF5	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	PANTR|Ensembl=ENSPTRG00000015646|UniProtKB=H2QNS5	Guanine nucleotide binding protein (G protein), beta polypeptide 4	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00005	Angiogenesis	P00240	FRS-2	CANLF|Ensembl=ENSCAFG00000032567|UniProtKB=J9NT83	Uncharacterized protein	ISS			PTHR21258:SF39	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 3
P00049	Parkinson disease	P01227	20S proteasome	DANRE|ZFIN=ZDB-GENE-040801-15|UniProtKB=Q6DGX8	Proteasome subunit alpha type	ISS	12859888	PubMed	PTHR11599:SF12	PROTEASOME SUBUNIT ALPHA TYPE-RELATED
P05730	Endogenous cannabinoid signaling	P05745	Gbeta	ORNAN|Ensembl=ENSOANG00000006378|UniProtKB=F6PGC8	Uncharacterized protein	ISS	11313908	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00018	EGF receptor signaling pathway	P00565	PKC	CANLF|Ensembl=ENSCAFG00000015695|UniProtKB=E2RGU7	Protein kinase C eta type	ISS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	14585994	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	MOUSE|MGI=MGI=87902|UniProtKB=P68134	Actin, alpha skeletal muscle	ISS	10974003	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	HUMAN|HGNC=4382|UniProtKB=O95837	Guanine nucleotide-binding protein subunit alpha-14	ISS	9009705	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00039	Metabotropic glutamate receptor group III pathway	P01042	SNARE Complex	RAT|RGD=3784|UniProtKB=P61265	Syntaxin-1B	ISS	1321498	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	ANOGA|EnsemblGenome=AGAP005543|UniProtKB=Q7PNQ5	AGAP005543-PA	IC	14570579	PubMed	PTHR19957:SF209	LD23667P
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	6754632	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CHICK|Ensembl=ENSGALG00000008907|UniProtKB=E1BY87	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05938	RhoA	MOUSE|MGI=MGI=1096342|UniProtKB=Q9QUI0	Transforming protein RhoA	RCA	12169092	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CANLF|Gene=PRKACA|UniProtKB=Q8MJ44	cAMP-dependent protein kinase catalytic subunit alpha	ISS	14744463	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	14600145	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00049	Parkinson disease	P01230	Src kinase	MONDO|Ensembl=ENSMODG00000000247|UniProtKB=F6WR53	Tyrosine-protein kinase	ISS	11078745	PubMed	PTHR24418:SF53	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
P00005	Angiogenesis	P00238	Ras	DANRE|ZFIN=ZDB-GENE-050417-95|UniProtKB=F1QNG4	Uncharacterized protein	ISS	91232861	PubMed	PTHR24070:SF385	GTPASE HRAS
P00012	Cadherin signaling pathway	P00471	Cadherin	CANLF|Ensembl=ENSCAFG00000003758|UniProtKB=F1PD90	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF9	PROTOCADHERIN-18
P00056	VEGF signaling pathway	P01417	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	8006597	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	PANTR|Ensembl=ENSPTRG00000019406|UniProtKB=H2QUX9	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF26	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT GAMMA-T1
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	CANLF|Ensembl=ENSCAFG00000010740|UniProtKB=P38400	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	1482697	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00050	Plasminogen activating cascade	P01253	Fibrin	MACMU|Ensembl=ENSMMUG00000021302|UniProtKB=F6UZ87	Uncharacterized protein	ISS	11761631	gi	PTHR19143:SF332	FIBRINOGEN BETA CHAIN
P02781	Threonine biosynthesis	P03192	Aspartate semialdehyde dehydrogenase	STRCO|Gene=CAB45481|UniProtKB=Q9XAI8	Aspartate-semialdehyde dehydrogenase	ISS			PTHR10174:SF2	ASPARTATE-SEMIALDEHYDE DEHYDROGENASE
P05915	Opioid proenkephalin pathway	P05987	peptide F	MOUSE|MGI=MGI=104629|UniProtKB=P22005	Proenkephalin-A	ISS	131330	OMIM	PTHR11438:SF3	PROENKEPHALIN-A
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	11790551	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02729	Ascorbate degradation	P02849	L-xylulose kinase	SCHPO|PomBase=SPCPJ732.02c|UniProtKB=Q9C0U6	Xylulose kinase	ISS			PTHR10196:SF57	XYLULOSE KINASE
P00045	Notch signaling pathway	G01541	E(spl)-C genes	MACMU|Ensembl=ENSMMUG00000022882|UniProtKB=F6WM03	Uncharacterized protein	ISS			PTHR10985:SF15	TRANSCRIPTION FACTOR HES-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05913	Enkephalin release	P05972	PKA	BOVIN|Ensembl=ENSBTAG00000014205|UniProtKB=P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00005	Angiogenesis	P00238	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	7997267	PubMed	PTHR24070:SF385	GTPASE HRAS
P00005	Angiogenesis	P00182	p38MAPK	BOVIN|Ensembl=ENSBTAG00000020783|UniProtKB=A6QLR9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00010	B cell activation	P00397	IKK	MOUSE|MGI=MGI=99484|UniProtKB=Q60680	Inhibitor of nuclear factor kappa-B kinase subunit alpha	IGI	14499113	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01143	ERK	BOVIN|Ensembl=ENSBTAG00000005865|UniProtKB=G5E577	Uncharacterized protein	ISS	8444355	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00739	AGS3	MOUSE|MGI=MGI=1915089|UniProtKB=Q6IR34	G-protein-signaling modulator 1	IDA	11121039	PubMed	PTHR10098:SF36	G-PROTEIN-SIGNALING MODULATOR 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	CHICK|Ensembl=ENSGALG00000017238|UniProtKB=F1NWG3	Uncharacterized protein	IDA	14614461	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	BOVIN|Ensembl=ENSBTAG00000010024|UniProtKB=F1MTK6	Uncharacterized protein	ISS	12834808	PubMed	PTHR10201:SF138	MATRIX METALLOPROTEINASE-24
P00005	Angiogenesis	P00253	Axin	MOUSE|MGI=MGI=1270862|UniProtKB=O88566	Axin-2	ISS	12356903	PubMed	PTHR10845:SF103	AXIN-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01083	GIRK	CHICK|Gene=KCNJ3|UniProtKB=Q90854	G protein-activated inward rectifier potassium channel 1	ISS	12374786	PubMed	PTHR11767:SF16	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	DROME|FlyBase=FBgn0259243|UniProtKB=P16905	cAMP-dependent protein kinase type I regulatory subunit	ISS	2372396	PubMed	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IDA	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00012	Cadherin signaling pathway	P00474	Wnt	XENTR|Xenbase=XB-GENE-479567|UniProtKB=A4ZGP0	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P06959	CCKR signaling map	P07092	IEX1	HUMAN|HGNC=5392|UniProtKB=P46695	Radiation-inducible immediate-early gene IEX-1	RCA	17704804	PubMed	PTHR16915:SF0	RADIATION-INDUCIBLE IMMEDIATE-EARLY GENE IEX-1
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000009579|UniProtKB=H2R3M7	Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1)	ISS	176910	OMIM	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00048	PI3 kinase pathway	P01190	PDK1 ACT	MOUSE|MGI=MGI=1338068|UniProtKB=Q9Z2A0	3-phosphoinositide-dependent protein kinase 1	IGI	11256888	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P02738	De novo purine biosynthesis	P02902	ADP reductase	BOVIN|Ensembl=ENSBTAG00000021208|UniProtKB=E1BFQ8	Uncharacterized protein	ISS			PTHR23409:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 B
P02736	Coenzyme A biosynthesis	P02884	Dephospho-CoA kinase	HUMAN|HGNC=26238|UniProtKB=Q8WVC6	Dephospho-CoA kinase domain-containing protein	ISS			PTHR10695:SF35	DEPHOSPHO-COA KINASE DOMAIN-CONTAINING PROTEIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	DANRE|ZFIN=ZDB-GENE-090312-2|UniProtKB=B8JIQ1	Uncharacterized protein	ISS	10704871	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P04398	p53 pathway feedback loops 2	P04656	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	12855688	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000002961|UniProtKB=F7GZP9	Guanine nucleotide-binding protein subunit alpha-11	ISS	12759536	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P06664	Gonadotropin-releasing hormone receptor pathway	P06733	PKCs	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	RCA	12640464	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	XENTR|Xenbase=XB-GENE-948769|UniProtKB=Q28HP6	Synaptosomal-associated protein	ISS	12805548	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00017	DNA replication	P00533	Pol delta	MACMU|Ensembl=ENSMMUG00000021525|UniProtKB=F7FF89	DNA polymerase	ISS	9620226	PubMed	PTHR10322:SF23	DNA POLYMERASE DELTA CATALYTIC SUBUNIT
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	TAKRU|Ensembl=ENSTRUG00000014690|UniProtKB=H2UKR9	Uncharacterized protein	IDA	11861492	PubMed	PTHR24248:SF87	D 2  DOPAMINE RECEPTOR
P04398	p53 pathway feedback loops 2	P04670	beta-catenin	BOVIN|Ensembl=ENSBTAG00000016420|UniProtKB=Q0VCX4	Catenin beta-1	ISS	7906389	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00056	VEGF signaling pathway	P01412	HSP27	CHICK|Ensembl=ENSGALG00000016199|UniProtKB=P02504	Alpha-crystallin A chain	ISS			PTHR11527:SF36	ALPHA-CRYSTALLIN A CHAIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05923	beta-ARR2	BOVIN|Gene=ARRB2|UniProtKB=P32120	Beta-arrestin-2	RCA	11742073	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00018	EGF receptor signaling pathway	P00551	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IGI	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MACMU|Ensembl=ENSMMUG00000005190|UniProtKB=F7CTP1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	ISS	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00034	Integrin signalling pathway	P00936	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	TAKRU|Ensembl=ENSTRUG00000010434|UniProtKB=H2TNL3	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00057	Wnt signaling pathway	P01438	PP2A	PANTR|Ensembl=ENSPTRG00000017238|UniProtKB=H2QRH7	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	MOUSE|MGI=MGI=97846|UniProtKB=Q05144	Ras-related C3 botulinum toxin substrate 2	ISS	12932731	PubMed	PTHR24072:SF169	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	9009705	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00034	Integrin signalling pathway	P00951	Jnk	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000023202|UniProtKB=F7EU36	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00056	VEGF signaling pathway	P01411	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	8473736	PubMed	PTHR24070:SF189	GTPASE NRAS
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12701063	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	MOUSE|MGI=MGI=2447811|UniProtKB=A6ZI46	Fructose-bisphosphate aldolase	ISS	6086339	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	DANRE|ZFIN=ZDB-GENE-050904-4|UniProtKB=Q3ZB92	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	DICDI|dictyBase=DDB_G0275023|UniProtKB=Q553U6	Putative actin-22	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEEL|WormBase=WBGene00004032|UniProtKB=P34885	Protein kinase C-like 1B	ISS	3045562	PubMed	PTHR24356:SF240	PROTEIN KINASE C
P02756	N-acetylglucosamine metabolism	P03042	Fructose-6-phosphate aminotransferase	MYCTU|EnsemblGenome=Rv3436c|UniProtKB=P9WN49	Glutamine--fructose-6-phosphate aminotransferase [isomerizing]	ISS			PTHR10937:SF0	GH12731P-RELATED
P00034	Integrin signalling pathway	P00940	Src	DROME|FlyBase=FBgn0262733|UniProtKB=P00528	Tyrosine-protein kinase Src64B	IPI	11078745	PubMed	PTHR24418:SF283	TYROSINE-PROTEIN KINASE SRC64B
P00029	Huntington disease	P00786	ARF	MACMU|Ensembl=ENSMMUG00000019688|UniProtKB=F6WTU5	Uncharacterized protein	ISS	12932731	PubMed	PTHR11711:SF110	ADP-RIBOSYLATION FACTOR 4
P02769	Purine metabolism	P03116	Xanthine Oxidase	HUMAN|HGNC=12805|UniProtKB=P47989	Xanthine dehydrogenase/oxidase	ISS	8135849	PubMed	PTHR11908:SF80	XANTHINE DEHYDROGENASE/OXIDASE
P00010	B cell activation	P00376	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	3029126	PubMed	PTHR24070:SF189	GTPASE NRAS
P04377	Beta1 adrenergic receptor signaling pathway	P04436	G-Protein	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	HUMAN|HGNC=4581|UniProtKB=Q13003	Glutamate receptor ionotropic, kainate 3	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00056	VEGF signaling pathway	P01413	PI3K	CAEEL|WormBase=WBGene00000090|UniProtKB=Q94125	Phosphatidylinositol 3-kinase age-1	ISS	96320556	PubMed	PTHR10048:SF14	PI-3 KINASE
P00059	p53 pathway	P01480	PTEN	PANTR|Ensembl=ENSPTRG00000002719|UniProtKB=H2Q280	Phosphatase and tensin homolog	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000013669|UniProtKB=F6TXC2	Mitogen-activated protein kinase	ISS	12810719	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00060	Ubiquitin proteasome pathway	P01491	E2	CHICK|Ensembl=ENSGALG00000005667|UniProtKB=E1C9E7	Uncharacterized protein	ISS			PTHR24067:SF154	UBIQUITIN-CONJUGATING ENZYME E2 G2
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	P01448	CBP	ARATH|TAIR=AT1G79000|UniProtKB=Q9C5X9	Histone acetyltransferase HAC1	ISS	8413673	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00018	EGF receptor signaling pathway	P00558	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	98043737	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	SCHPO|PomBase=SPAC31G5.09c|UniProtKB=P27638	Mitogen-activated protein kinase spk1	ISS	19114921	gi	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00021	FGF signaling pathway	P00627	ERK1-2	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	97102671	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000002674|UniProtKB=P02698	Guanine nucleotide-binding protein G(T) subunit gamma-T1	IDA	3100519	PubMed	PTHR13809:SF26	GUANINE NUCLEOTIDE-BINDING PROTEIN G T  SUBUNIT GAMMA-T1
P05917	Opioid proopiomelanocortin pathway	P06009	K+ channel	MOUSE|MGI=MGI=1100509|UniProtKB=O35111	Potassium channel subfamily K member 3	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00902	GSK-3	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	183955	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00049	Parkinson disease	P01238	14-3-3	PANTR|Ensembl=ENSPTRG00000019320|UniProtKB=H2QUT2	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	ISS	99360936	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00056	VEGF signaling pathway	P01425	PKC	BOVIN|Ensembl=ENSBTAG00000010664|UniProtKB=E1BMG4	Protein kinase C	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P02775	Salvage pyrimidine ribonucleotides	P03153	Cytidylate kinase	PANTR|Ensembl=ENSPTRG00000000712|UniProtKB=H2PYZ9	UMP-CMP kinase	ISS			PTHR23359:SF107	UMP-CMP KINASE
P00059	p53 pathway	P01486	Akt	BOVIN|Ensembl=ENSBTAG00000001400|UniProtKB=E1B9D1	Uncharacterized protein	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00701	GPRK	BOVIN|Ensembl=ENSBTAG00000007981|UniProtKB=P43249	G protein-coupled receptor kinase 5	IDA	8288567	PubMed	PTHR24355:SF27	G PROTEIN-COUPLED RECEPTOR KINASE 5
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1203730|UniProtKB=O70167	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	IDA	9514948	PubMed	PTHR10048:SF29	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	PANTR|Ensembl=ENSPTRG00000000098|UniProtKB=G2HIJ9	Uncharacterized protein	ISS	93386758	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000001270|UniProtKB=E1BQN6	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P06959	CCKR signaling map	P07228	MAPK1/3	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	RCA	11546808	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02772	Pyruvate metabolism	P03137	Citrate Lyase	PSEAE|EnsemblGenome=PA0883|UniProtKB=Q9I562	Probable acyl-CoA lyase beta chain	ISS			PTHR32308:SF0	CITRATE LYASE SUBUNIT BETA
P06664	Gonadotropin-releasing hormone receptor pathway	P06854	IGF-1	MOUSE|MGI=MGI=96432|UniProtKB=P05017	Insulin-like growth factor I	RCA			PTHR11454:SF4	INSULIN-LIKE GROWTH FACTOR I
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MOUSE|MGI=MGI=1336882|UniProtKB=O70404	Vesicle-associated membrane protein 8	ISS	14997396	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00052	TGF-beta signaling pathway	P01284	JNK	BOVIN|Ensembl=ENSBTAG00000007876|UniProtKB=F1MM73	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	CAEEL|WormBase=WBGene00004364|UniProtKB=A5PEW5	Synaptosomal-associated protein	IC	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00020	FAS signaling pathway	P00601	c-Jun	MACMU|Ensembl=ENSMMUG00000032072|UniProtKB=F7A6Z1	Transcription factor AP-1	ISS	10487205	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	PANTR|Ensembl=ENSPTRG00000019574|UniProtKB=H2RER5	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	RAT|RGD=2747|UniProtKB=P35349	Metabotropic glutamate receptor 6	ISS	12488551	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00029	Huntington disease	P00790	beta-Tubulin	CHICK|Ensembl=ENSGALG00000008586|UniProtKB=F1NYB1	Uncharacterized protein	TAS	9454836	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P00053	T cell activation	P01320	PLC-gamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IDA	11994416	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00045	Notch signaling pathway	P01105	TACE	HUMAN|HGNC=195|UniProtKB=P78536	Disintegrin and metalloproteinase domain-containing protein 17	ISS	9774383	PubMed	PTHR11905:SF171	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17
P05912	Dopamine receptor mediated signaling pathway	P05949	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	8617307	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	DANRE|ZFIN=ZDB-GENE-020125-4|UniProtKB=F1QKT1	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	1504106	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MACMU|Ensembl=ENSMMUG00000022182|UniProtKB=F6XHP0	Guanine nucleotide-binding protein subunit gamma	ISS	2122451	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00020	FAS signaling pathway	P00615	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	9393873	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00056	VEGF signaling pathway	P01425	PKC	XENTR|Xenbase=XB-GENE-981655|UniProtKB=Q08BT6	Protein kinase C epsilon type	ISS	88083621	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	RAT|RGD=1310074|UniProtKB=Q6AY23	Pyrroline-5-carboxylate reductase 2	ISS			PTHR11645:SF4	PYRROLINE-5-CARBOXYLATE REDUCTASE 2
P00049	Parkinson disease	P01236	Casein kinase II	NEUCR|EnsemblGenome=EFNCRG00000001945|UniProtKB=Q8TG11	Casein kinase II subunit beta-2	IDA	10617630	PubMed	PTHR22746:SF10	RAB6A-GEF COMPLEX PARTNER PROTEIN 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	8717339	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00048	PI3 kinase pathway	P01182	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IDA	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00006	Apoptosis signaling pathway	P00297	NFkappaB	MOUSE|MGI=MGI=97312|UniProtKB=P25799	Nuclear factor NF-kappa-B p105 subunit	IDA	11739545	PubMed	PTHR24169:SF9	NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT
P00021	FGF signaling pathway	P00640	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	LEIMA|EnsemblGenome=LmjF.35.4010|UniProtKB=Q9GNR4	Protein kinase A catalytic subunit isoform 1	ISS	14744463	PubMed	PTHR24353:SF67	SUBFAMILY NOT NAMED
P00009	Axon guidance mediated by netrin	P00363	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	1171954	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P02734	Chorismate biosynthesis	P02874	Shikimate kinase	STRCO|EnsemblGenome=CAB93375|UniProtKB=Q9KXQ5	Shikimate kinase	ISS			PTHR21087:SF0	SHIKIMATE KINASE 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	ISS	14609720	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00021	FGF signaling pathway	P00627	ERK1-2	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	1504106	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PANTR|Ensembl=ENSPTRG00000018890|UniProtKB=Q5R1X3	Actin, cytoplasmic 1	ISS	11889126	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MONDO|Ensembl=ENSMODG00000012546|UniProtKB=F6PM16	Uncharacterized protein	ISS	15621031	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00034	Integrin signalling pathway	P00951	Jnk	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	IDA	11707292	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00059	p53 pathway	G01565	PERP	HUMAN|HGNC=17637|UniProtKB=Q96FX8	p53 apoptosis effector related to PMP-22	ISS	10733530	PubMed	PTHR14399:SF4	P53 APOPTOSIS EFFECTOR RELATED TO PMP-22
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00018	EGF receptor signaling pathway	P00565	PKC	MACMU|Ensembl=ENSMMUG00000016438|UniProtKB=F7GTQ2	Serine/threonine-protein kinase	ISS	12676944	PubMed	PTHR22968:SF14	SERINE/THREONINE-PROTEIN KINASE D3
P05918	p38 MAPK pathway	P06021	Rac	DANRE|ZFIN=ZDB-GENE-040718-256|UniProtKB=Q6DGB7	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3)	ISS	12676940	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00048	PI3 kinase pathway	P01177	P110ACT	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00021	FGF signaling pathway	P00640	PI3K	CANLF|Ensembl=ENSCAFG00000007579|UniProtKB=F6Y841	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10395542	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000030785|UniProtKB=F6ZVQ1	Uncharacterized protein	ISS	11691998	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00060	Ubiquitin proteasome pathway	P01492	E1	MACMU|Ensembl=ENSMMUG00000020980|UniProtKB=F7HMU2	Uncharacterized protein	ISS			PTHR10953:SF143	UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 7
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01077	mAChR2/4	RAT|RGD=2344|UniProtKB=P08485	Muscarinic acetylcholine receptor M4	ISS	10069496	PubMed	PTHR43914:SF6	MUSCARINIC ACETYLCHOLINE RECEPTOR M4
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	MACMU|Ensembl=ENSMMUG00000013637|UniProtKB=F7GL52	Uncharacterized protein	ISS	10206645	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000003795|UniProtKB=H2Q3X5	Muscarinic acetylcholine receptor	ISS			PTHR43914:SF7	MUSCARINIC ACETYLCHOLINE RECEPTOR M1
P05731	GABA-B receptor II signaling	P05752	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	MONDO|Ensembl=ENSMODG00000005255|UniProtKB=F7G800	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00060	Ubiquitin proteasome pathway	P01491	E2	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g236730|UniProtKB=A7RXR8	Predicted protein	ISS			PTHR24068:SF74	FI16911P1-RELATED
P00006	Apoptosis signaling pathway	P00310	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P04393	Ras Pathway	P04567	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000021437|UniProtKB=H2QXZ6	Uncharacterized protein	ISS	10644715	PubMed	PTHR24356:SF175	SERINE/THREONINE-PROTEIN KINASE N3
P00030	Hypoxia response via HIF activation	P00819	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	176910	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P05916	Opioid prodynorphin pathway	P06002	G-protein	TAKRU|Ensembl=ENSTRUG00000017578|UniProtKB=H2V772	Uncharacterized protein	ISS			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00034	Integrin signalling pathway	P00936	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	DROME|FlyBase=FBgn0028875|UniProtKB=Q7KT97	Nicotinic acetylcholine receptor alpha5, isoform B	ISS	85270494	PubMed	PTHR18945:SF770	NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA5, ISOFORM B
P00048	PI3 kinase pathway	P01199	Galpha	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00896	Insulin IGF	XENTR|Xenbase=XB-GENE-480239|UniProtKB=F6V1C3	Uncharacterized protein	ISS			PTHR11454:SF4	INSULIN-LIKE GROWTH FACTOR I
P00034	Integrin signalling pathway	P00922	Collagen	BOVIN|Ensembl=ENSBTAG00000014575|UniProtKB=F1N474	Uncharacterized protein	ISS	10778855	PubMed	PTHR24023:SF847	COLLAGEN ALPHA-5 IV  CHAIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	RAT|RGD=68438|UniProtKB=P35370	Nociceptin receptor	IDA	11259498	PubMed	PTHR24229:SF11	NOCICEPTIN RECEPTOR
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MACMU|Ensembl=ENSMMUG00000001980|UniProtKB=F6VAR2	Uncharacterized protein	ISS	14644163	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00751	Ggamma	MOUSE|MGI=MGI=893584|UniProtKB=Q61017	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	IDA	2122451	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	HUMAN|HGNC=4038|UniProtKB=Q9UP38	Frizzled-1	TAS	11212302	PubMed	PTHR11309:SF81	FRIZZLED-1
P04393	Ras Pathway	P04542	ERK	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	8759724	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00005	Angiogenesis	P00253	Axin	DANRE|ZFIN=ZDB-GENE-000403-2|UniProtKB=P57095	Axin-2	ISS	9554852	PubMed	PTHR10845:SF103	AXIN-2
P00029	Huntington disease	P00776	c-Jun	XENTR|Xenbase=XB-GENE-482228|UniProtKB=F6RYL1	Uncharacterized protein	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00055	Transcription regulation by bZIP transcription factor	P01383	CREB	MOUSE|MGI=MGI=2443973|UniProtKB=Q8K1L0	Cyclic AMP-responsive element-binding protein 5	RCA			PTHR19304:SF8	CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 5
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	TAS	3045562	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00056	VEGF signaling pathway	P01423	p38MAPK	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	10092590	gi	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00759	PDEalphabeta	BOVIN|Gene=PDE6B|UniProtKB=P23439	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	ISS			PTHR11347:SF73	ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	HUMAN|HGNC=7463|UniProtKB=P48039	Melatonin receptor type 1A	IDA			PTHR43962:SF2	MELATONIN RECEPTOR TYPE 1A
P00059	p53 pathway	P04609	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	ISS	12660731	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P02757	O-antigen biosynthesis	P03050	dTDP-4-dehydrorhamnose reductase	MONDO|Ensembl=ENSMODG00000007609|UniProtKB=F7C5P3	Uncharacterized protein	ISS			PTHR10491:SF4	METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	BOVIN|Ensembl=ENSBTAG00000002908|UniProtKB=A4IFL6	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P06587	Nicotine pharmacodynamics pathway	P06588	PRKACA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	TAS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00029	Huntington disease	P00777	CBP	PANTR|Ensembl=ENSPTRG00000007710|UniProtKB=H2QAH3	Uncharacterized protein	ISS	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	PANTR|Ensembl=ENSPTRG00000014093|UniProtKB=H2QLA1	Synaptosomal-associated protein, 29kDa	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	11724916	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00047	PDGF signaling pathway	P01143	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00003	Alzheimer disease-amyloid secretase pathway	P00098	Presenilin	PANTR|Ensembl=ENSPTRG00000006510|UniProtKB=H2Q8K1	Presenilin	ISS	14598311	PubMed	PTHR10202:SF18	PRESENILIN-1
P00046	Oxidative stress response	P01125	Stat1	MACMU|Ensembl=ENSMMUG00000005613|UniProtKB=F6WE02	Signal transducer and activator of transcription	ISS	10207096	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	MOUSE|MGI=MGI=95787|UniProtKB=Q61016	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IC			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00005	Angiogenesis	P00219	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	ISS	2611232	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MOUSE|MGI=MGI=95816|UniProtKB=B1AS29	Glutamate receptor ionotropic, kainate 3	ISS	12778120	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00017	DNA replication	P00535	5' to 3' Exoribonulcease	YEAST|SGD=S000003141|UniProtKB=P22147	5'-3' exoribonuclease 1	ISS	97313265	PubMed	PTHR12341:SF7	5'-3' EXORIBONUCLEASE 1
P04398	p53 pathway feedback loops 2	P04657	P110alpha	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	IC	11238629	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04397	p53 pathway by glucose deprivation	P04640	p53	PANTR|Ensembl=ENSPTRG00000008703|UniProtKB=H2QC53	Cellular tumor antigen p53	ISS	11313951	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P02738	De novo purine biosynthesis	P02909	GDP reductase	PSEAE|EnsemblGenome=PA1155|UniProtKB=Q9I4I2	Ribonucleoside-diphosphate reductase subunit beta	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00251	cPLA2	MONDO|Ensembl=ENSMODG00000011791|UniProtKB=F7CBU9	Phospholipase A2	ISS	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00021	FGF signaling pathway	P00641	SOS	HUMAN|HGNC=11187|UniProtKB=Q07889	Son of sevenless homolog 1	IPI	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	FUSNN|EnsemblGenome=FN0103|UniProtKB=Q8RH17	Ribonucleoside-diphosphate reductase subunit beta	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P04398	p53 pathway feedback loops 2	P04659	PP2A-C	DICDI|dictyBase=DDB_G0290263|UniProtKB=Q9XZE5	Serine/threonine-protein phosphatase 2A catalytic subunit A	ISS	99379588	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	CAEBR|Gene=CBG19814|UniProtKB=A8XW88	cAMP-dependent protein kinase catalytic subunit	ISS	10553940	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P00054	Toll receptor signaling pathway	P01379	Tollip	BOVIN|Ensembl=ENSBTAG00000008237|UniProtKB=Q2LGB5	Toll-interacting protein	ISS			PTHR16461:SF5	TOLL-INTERACTING PROTEIN
P00047	PDGF signaling pathway	P01159	SOS	MONDO|Ensembl=ENSMODG00000011821|UniProtKB=F6YCI3	Uncharacterized protein	ISS	476780	gi	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00036	Interleukin signaling pathway	P00965	ERK	RAT|RGD=628675|UniProtKB=Q9Z2A6	Mitogen-activated protein kinase 15	TAS	10514528	PubMed	PTHR24055:SF79	MITOGEN-ACTIVATED PROTEIN KINASE 15
P04393	Ras Pathway	P04558	p38	MACMU|Ensembl=ENSMMUG00000014107|UniProtKB=F7C798	Mitogen-activated protein kinase	ISS	96279333	PubMed	PTHR24055:SF109	MITOGEN-ACTIVATED PROTEIN KINASE 11
P00021	FGF signaling pathway	P00633	Ras	MOUSE|MGI=MGI=96224|UniProtKB=Q61411	GTPase HRas	IGI	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P00052	TGF-beta signaling pathway	P01284	JNK	CANLF|Ensembl=ENSCAFG00000000395|UniProtKB=F1P630	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04397	p53 pathway by glucose deprivation	P04640	p53	DANRE|ZFIN=ZDB-GENE-990415-270|UniProtKB=P79734	Cellular tumor antigen p53	TAS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00034	Integrin signalling pathway	P00951	Jnk	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	IDA	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	IDA	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00059	p53 pathway	P04623	CBP	HUMAN|HGNC=2348|UniProtKB=Q92793	CREB-binding protein	IDA	12732631	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	PANTR|Ensembl=ENSPTRG00000010952|UniProtKB=H2Q960	Uncharacterized protein	ISS			PTHR24361:SF182	SERINE/THREONINE-PROTEIN KINASE PAK 6
P00004	Alzheimer disease-presenilin pathway	P00114	actin	RAT|RGD=2027|UniProtKB=P63269	Actin, gamma-enteric smooth muscle	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P00018	EGF receptor signaling pathway	P00547	PP2A	CANLF|Ensembl=ENSCAFG00000015787|UniProtKB=F6V7D9	Uncharacterized protein	ISS	10092233	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P04395	Vasopressin synthesis	P04595	Pro2-Vasopressin	HUMAN|HGNC=894|UniProtKB=P01185	Vasopressin-neurophysin 2-copeptin	ISS	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00006	Apoptosis signaling pathway	P00310	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MONDO|Ensembl=ENSMODG00000018145|UniProtKB=F7CXD0	Uncharacterized protein	ISS	12270649	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04387	Histamine synthesis	P04493	Histidine decarboxylase	DROME|FlyBase=FBgn0005619|UniProtKB=Q05733	Histidine decarboxylase	ISS	1702422	PubMed	PTHR11999:SF68	HISTIDINE DECARBOXYLASE
P00006	Apoptosis signaling pathway	P00298	Caspase 9	HUMAN|HGNC=1511|UniProtKB=P55211	Caspase-9	IDA	11440972	PubMed	PTHR10454:SF157	CASPASE-9
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00738	Clathrin	DROME|FlyBase=FBgn0024814|UniProtKB=Q9VWA1	Clathrin light chain	IDA	9388255	PubMed	PTHR10639:SF7	CLATHRIN LIGHT CHAIN
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	1372523	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00046	Oxidative stress response	P01131	MKP5	ARATH|TAIR=AT3G23610|UniProtKB=Q9ZR37	Dual specificity protein phosphatase 1	ISS			PTHR10159:SF402	DUAL SPECIFICITY PROTEIN PHOSPHATASE 19
P00047	PDGF signaling pathway	P01160	IP3 receptor	HUMAN|HGNC=6180|UniProtKB=Q14643	Inositol 1,4,5-trisphosphate receptor type 1	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	DANRE|ZFIN=ZDB-GENE-051227-1|UniProtKB=Q6RKB0	Skeletal muscle L-type calcium channel alpha1S subunit	ISS	8838325	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00034	Integrin signalling pathway	P00951	Jnk	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05913	Enkephalin release	P05972	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	1319556	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00010	B cell activation	P00384	p38	CHICK|Ensembl=ENSGALG00000019759|UniProtKB=F1NDG1	Mitogen-activated protein kinase	ISS	7914033	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04379	Beta3 adrenergic receptor signaling pathway	P04448	G-Protein	MACMU|Ensembl=ENSMMUG00000010266|UniProtKB=F6PV18	Uncharacterized protein	ISS	6309844	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P05913	Enkephalin release	P05972	PKA	DANRE|ZFIN=ZDB-GENE-040426-1351|UniProtKB=Q7T374	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	HUMAN|HGNC=11332|UniProtKB=P32745	Somatostatin receptor type 3	IDA	12181435	PubMed	PTHR24229:SF42	SOMATOSTATIN RECEPTOR TYPE 3
P00054	Toll receptor signaling pathway	P01352	p38	PANTR|Ensembl=ENSPTRG00000018097|UniProtKB=Q95NE7	Mitogen-activated protein kinase 14	ISS	9688607	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02738	De novo purine biosynthesis	P02909	GDP reductase	ECOLI|EcoGene=EG10660|UniProtKB=P00452	Ribonucleoside-diphosphate reductase 1 subunit alpha	ISS			PTHR11573:SF6	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT
P00005	Angiogenesis	P00220	c-Jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00029	Huntington disease	P00780	Microtubule	ORYSJ|EnsemblGenome=OS05G0413200|UniProtKB=Q76FS3	Tubulin beta-6 chain	IDA	9454836	PubMed	PTHR11588:SF249	SUBFAMILY NOT NAMED
P00012	Cadherin signaling pathway	P00471	Cadherin	PANTR|Ensembl=ENSPTRG00000017355|UniProtKB=H2QRP0	Uncharacterized protein	ISS	8120095	PubMed	PTHR24028:SF42	PROTOCADHERIN-12
P00004	Alzheimer disease-presenilin pathway	P00127	APP	HUMAN|HGNC=620|UniProtKB=P05067	Amyloid beta A4 protein	IDA	11441186	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00054	Toll receptor signaling pathway	P01346	TLR	DROME|FlyBase=FBgn0004364|UniProtKB=A1ZBR2	18 wheeler	ISS			PTHR44740:SF1	18 WHEELER-RELATED
P00047	PDGF signaling pathway	P01162	MEK	CANLF|Ensembl=ENSCAFG00000019138|UniProtKB=Q1HG70	Dual specificity mitogen-activated protein kinase kinase 2	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00012	Cadherin signaling pathway	P00471	Cadherin	RAT|RGD=1565811|UniProtKB=F1M6B6	Protein Pcdh10	ISS	8120095	PubMed	PTHR24028:SF0	PROTOCADHERIN-10
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00059	p53 pathway	P04610	Cyclin E	PANTR|Ensembl=ENSPTRG00000010782|UniProtKB=H2R677	Cyclin E1	ISS	12628165	PubMed	PTHR10177:SF71	G1/S-SPECIFIC CYCLIN-E1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	MOUSE|MGI=MGI=104874|UniProtKB=Q60823	RAC-beta serine/threonine-protein kinase	ISS	11861503	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00811	Arp2/3 complex	ORNAN|Ensembl=ENSOANG00000000999|UniProtKB=F6WN02	Actin-related protein 2/3 complex subunit 5	ISS	10322212	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00034	Integrin signalling pathway	P00925	MEK	CHICK|Ensembl=ENSGALG00000007687|UniProtKB=Q5ZIF0	Uncharacterized protein	ISS	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	MONDO|Ensembl=ENSMODG00000025146|UniProtKB=F7CLC0	Uncharacterized protein	ISS	3885394	PubMed	PTHR23050:SF311	CALMODULIN
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	10993882	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01242	Casein kinase I	PANTR|Ensembl=ENSPTRG00000005793|UniProtKB=H2REV2	Uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF139	CASEIN KINASE I ISOFORM ALPHA-LIKE
P00018	EGF receptor signaling pathway	P00561	STAT	CANLF|Ensembl=ENSCAFG00000015346|UniProtKB=E2RE22	Signal transducer and activator of transcription	ISS	7514531	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00040	Metabotropic glutamate receptor group II pathway	P01047	G-protein	ARATH|TAIR=AT4G34460|UniProtKB=P49177	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF48	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	DANRE|ZFIN=ZDB-GENE-081104-25|UniProtKB=B8JLJ7	Uncharacterized protein	ISS	8838318	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-468|UniProtKB=Q5TZ66	Synaptosomal-associated protein 25-A	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P02755	Methylmalonyl pathway	P03033	Propionyl-CoA carboxylase	BOVIN|Ensembl=ENSBTAG00000015221|UniProtKB=Q2TBR0	Propionyl-CoA carboxylase beta chain, mitochondrial	ISS			PTHR43842:SF2	PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	CANLF|Ensembl=ENSCAFG00000000132|UniProtKB=J9P309	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	YEAST|SGD=S000001855|UniProtKB=P60010	Actin	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00029	Huntington disease	P00779	TBP	CANLF|Ensembl=ENSCAFG00000004119|UniProtKB=F1PQA5	Uncharacterized protein	ISS	11988536	PubMed	PTHR10126:SF20	TATA-BOX-BINDING PROTEIN
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00019	Endothelin signaling pathway	P00591	PLCbeta	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	8687401	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00036	Interleukin signaling pathway	P00965	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	10514528	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT1G53510|UniProtKB=Q9C5C0	Mitogen-activated protein kinase 18	ISS	15220806	gi	PTHR24055:SF200	MITOGEN-ACTIVATED PROTEIN KINASE 18-RELATED
P00049	Parkinson disease	P01227	20S proteasome	DROME|FlyBase=FBgn0032492|UniProtKB=Q9VK14	Proteasome subunit alpha type	TAS	12859888	PubMed	PTHR11599:SF12	PROTEASOME SUBUNIT ALPHA TYPE-RELATED
P00052	TGF-beta signaling pathway	P01279	Smurfs	RAT|RGD=1310067|UniProtKB=F1M3F2	Protein Smurf2	ISS	11252892	PubMed	PTHR11254:SF300	E3 UBIQUITIN-PROTEIN LIGASE SMURF2
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	TAS	2611232	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	10644715	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000012943|UniProtKB=F7G1K7	Uncharacterized protein	ISS	9009705	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	14526383	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	ISS	176910	OMIM	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P04398	p53 pathway feedback loops 2	P04648	p38 MAPK	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	IDA	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02921	UDP reductase	MOUSE|MGI=MGI=2155865|UniProtKB=Q6PEE3	Ribonucleoside-diphosphate reductase subunit M2 B	ISS			PTHR23409:SF19	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 B
P00057	Wnt signaling pathway	P01471	alpha-catenin	MONDO|Ensembl=ENSMODG00000012050|UniProtKB=F7ALE8	Uncharacterized protein	ISS	1768802	PubMed	PTHR18914:SF24	CATENIN ALPHA-1
P00019	Endothelin signaling pathway	P00570	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	2372396	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P04393	Ras Pathway	P04567	PI3K	RAT|RGD=620899|UniProtKB=O88763	Phosphatidylinositol 3-kinase catalytic subunit type 3	IDA	12707323	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00036	Interleukin signaling pathway	P00972	MNK1/2	MOUSE|MGI=MGI=894279|UniProtKB=Q8CDB0	MAP kinase-interacting serine/threonine-protein kinase 2	IC	9155017	PubMed	PTHR24349:SF243	MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2
P00021	FGF signaling pathway	P00634	MEKK1-5	BOVIN|Ensembl=ENSBTAG00000020079|UniProtKB=F1N3T0	Uncharacterized protein	ISS	9305639	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00006	Apoptosis signaling pathway	P00301	Apaf-1	MACMU|Ensembl=ENSMMUG00000022404|UniProtKB=F6U0K7	Apoptotic protease-activating factor 1	ISS	9267021	PubMed	PTHR22845:SF5	APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CAEEL|WormBase=WBGene00002178|UniProtKB=Q8WQG9	Stress-activated protein kinase jnk-1	IDA	11707292	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00021	FGF signaling pathway	P00647	SHP2	TAKRU|Ensembl=ENSTRUG00000018529|UniProtKB=H2VDZ2	Tyrosine-protein phosphatase non-receptor type	ISS	1382983	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00010	B cell activation	P00379	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	93262494	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P02766	Phenylethylamine degradation	P03103	Phenylethylamine oxidase	PANTR|Ensembl=ENSPTRG00000009226|UniProtKB=H2QD42	Amine oxidase	ISS			PTHR10638:SF4	RETINA-SPECIFIC COPPER AMINE OXIDASE
P00034	Integrin signalling pathway	P00932	FAK	MOUSE|MGI=MGI=95481|UniProtKB=P34152	Focal adhesion kinase 1	IPI	12640026	PubMed	PTHR24418:SF78	FOCAL ADHESION KINASE 1
P00021	FGF signaling pathway	P00638	PLCgamma	RAT|RGD=3347|UniProtKB=P10686	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	IGI	14568990	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00018	EGF receptor signaling pathway	P00543	ERK1-2	USTMA|Gene=UMAG_03305|UniProtKB=A0A0D1C4Y4	Mitogen-activated protein kinase	IGI	20032362	PubMed	PTHR24055:SF330	SUBFAMILY NOT NAMED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	HUMAN|HGNC=11132|UniProtKB=P60880	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00049	Parkinson disease	P01238	14-3-3	MACMU|Ensembl=ENSMMUG00000000721|UniProtKB=F7H4H9	Uncharacterized protein	ISS	10407019	PubMed	PTHR18860:SF3	14-3-3 PROTEIN THETA
P04393	Ras Pathway	P04567	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00856	CHK	HUMAN|HGNC=10637|UniProtKB=P02778	C-X-C motif chemokine 10	ISS	10946576	gi	PTHR10179:SF47	C-X-C MOTIF CHEMOKINE 10
P04393	Ras Pathway	P04568	MKK3/6	MOUSE|MGI=MGI=1346868|UniProtKB=O09110	Dual specificity mitogen-activated protein kinase kinase 3	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00030	Hypoxia response via HIF activation	P00819	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	CHICK|Gene=MYH3|UniProtKB=P02565	Myosin-1B	ISS	10938134	PubMed	PTHR13140:SF657	MYOSIN-4
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05943	GRK2	MOUSE|MGI=MGI=87940|UniProtKB=Q99MK8	Beta-adrenergic receptor kinase 1	RCA	8288567	PubMed	PTHR24355:SF22	BETA-ADRENERGIC RECEPTOR KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	BOVIN|Ensembl=ENSBTAG00000006189|UniProtKB=P63258	Actin, cytoplasmic 2	ISS	10974003	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00053	T cell activation	P01311	Raf	BOVIN|Ensembl=ENSBTAG00000021761|UniProtKB=F1MDL4	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00036	Interleukin signaling pathway	P00981	SOS	PANTR|Ensembl=ENSPTRG00000006328|UniProtKB=H2R2D5	Uncharacterized protein	ISS	1631150	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00021	FGF signaling pathway	P00642	MEK1-2	MONDO|Ensembl=ENSMODG00000009715|UniProtKB=F6XT65	Uncharacterized protein	ISS	10395662	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00005	Angiogenesis	P00235	c-Fos	TAKRU|Ensembl=ENSTRUG00000010579|UniProtKB=H2TPU7	Uncharacterized protein	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	HUMAN|HGNC=4400|UniProtKB=P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00060	Ubiquitin proteasome pathway	P01491	E2	CHICK|Ensembl=ENSGALG00000014290|UniProtKB=F1NIP7	Uncharacterized protein	ISS			PTHR44020:SF2	UBIQUITIN-CONJUGATING ENZYME E2 K
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BOVIN|Gene=ACTB|UniProtKB=P60712	Actin, cytoplasmic 1	ISS	14684598	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	STRPU|EnsemblGenome=SPU_018419|UniProtKB=W4YRI6	Uncharacterized protein	ISS	10074940	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00037	Ionotropic glutamate receptor pathway	P01017	Glu2	BOVIN|Ensembl=ENSBTAG00000004775|UniProtKB=F1MBY1	Uncharacterized protein	ISS	12871085	PubMed	PTHR18966:SF99	GLUTAMATE RECEPTOR 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	HUMAN|HGNC=2188|UniProtKB=Q99715	Collagen alpha-1(XII) chain	IC	10778855	PubMed	PTHR45047:SF2	COLLAGEN ALPHA-1 XII  CHAIN
P00018	EGF receptor signaling pathway	P00539	14-3-3	CHICK|Gene_ORFName=RCJMB04_5e12|UniProtKB=Q5F3W6	14-3-3 protein gamma	ISS	1317796	PubMed	PTHR18860:SF22	14-3-3 PROTEIN GAMMA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	PANTR|Ensembl=ENSPTRG00000000440|UniProtKB=H2PYH8	Uncharacterized protein	ISS	12093103	PubMed	PTHR24229:SF2	DELTA-TYPE OPIOID RECEPTOR
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	MACMU|Ensembl=ENSMMUG00000002924|UniProtKB=F7H1Q7	Rho-related GTP-binding protein RhoU	ISS			PTHR24072:SF148	RHO-RELATED GTP-BINDING PROTEIN RHOU
P00009	Axon guidance mediated by netrin	P00364	cdc42	MACMU|Ensembl=ENSMMUG00000022009|UniProtKB=F6RBZ7	Cell division control protein 42 homolog isoform 2	ISS	4757952	gi	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00048	PI3 kinase pathway	P01182	Ras	DANRE|ZFIN=ZDB-GENE-050522-466|UniProtKB=Q503B6	-Ha-ras Harvey rat sarcoma viral oncogene homolog, like	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00057	Wnt signaling pathway	P01432	Beta-Catenin	MONDO|Ensembl=ENSMODG00000011192|UniProtKB=F6SRK5	Uncharacterized protein	ISS	15001769	PubMed	PTHR23315:SF53	CATENIN BETA-1
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00020	FAS signaling pathway	P00615	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00036	Interleukin signaling pathway	P00973	PKB	HUMAN|HGNC=392|UniProtKB=P31751	RAC-beta serine/threonine-protein kinase	ISS	4502023	gi	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	1170702	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	RAT|RGD=1305941|UniProtKB=F1M324	Phosphoinositide phospholipase C	ISS			PTHR10336:SF84	INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2
P02749	Leucine biosynthesis	P03002	Isopropylmalate isomerase	YARLI|EnsemblGenome=YALI0_B01364g|UniProtKB=Q6CG29	3-isopropylmalate dehydratase	ISS			PTHR43822:SF3	3-ISOPROPYLMALATE DEHYDRATASE
P00029	Huntington disease	P00774	Dynein complex	CHICK|Ensembl=ENSGALG00000009551|UniProtKB=F1P3C8	Uncharacterized protein	ISS	9454836	PubMed	PTHR12442:SF22	CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN 2
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00723	beta-arrestin	DROME|FlyBase=FBgn0040206|UniProtKB=Q9V393	Kurtz arrestin	IDA	4757780	gi	PTHR11792:SF17	KURTZ ARRESTIN
P00048	PI3 kinase pathway	P01178	Grb2	DANRE|ZFIN=ZDB-GENE-040426-1975|UniProtKB=Q6PC73	Growth factor receptor-bound protein 2	ISS	51702266	gi	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	RAT|RGD=2139|UniProtKB=P08592	Amyloid beta A4 protein	TAS	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00060	Ubiquitin proteasome pathway	P01491	E2	CANLF|Ensembl=ENSCAFG00000010509|UniProtKB=E2RGY5	Uncharacterized protein	ISS			PTHR44511:SF1	UBIQUITIN-CONJUGATING ENZYME E2 T
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	HUMAN|HGNC=4410|UniProtKB=O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00047	PDGF signaling pathway	P01143	ERK	MACMU|Ensembl=ENSMMUG00000008503|UniProtKB=F6TGJ6	Uncharacterized protein	ISS	8444355	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00036	Interleukin signaling pathway	P00985	PDK1/2	HUMAN|HGNC=8816|UniProtKB=O15530	3-phosphoinositide-dependent protein kinase 1	ISS	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00010	B cell activation	P00375	Calmodulin	MONDO|Ensembl=ENSMODG00000023174|UniProtKB=F7D7P2	Uncharacterized protein	ISS	10487978	PubMed	PTHR23050:SF197	CALMODULIN-LIKE PROTEIN 3
P00005	Angiogenesis	P00249	PAK	CHICK|Ensembl=ENSGALG00000008058|UniProtKB=F1N8W8	Uncharacterized protein	ISS	15187108	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00053	T cell activation	P01331	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00034	Integrin signalling pathway	P00924	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	8006597	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	94043281	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00018	EGF receptor signaling pathway	P00552	Ras	CHICK|Ensembl=ENSGALG00000026692|UniProtKB=Q5F352	GTPase NRas	ISS	7997267	PubMed	PTHR24070:SF189	GTPASE NRAS
P00047	PDGF signaling pathway	P01167	Ets	DROME|FlyBase=FBgn0000567|UniProtKB=P11536	Ecdysone-induced protein 74EF isoform B	ISS	15298723	PubMed	PTHR11849:SF191	ECDYSONE-INDUCED PROTEIN 74EF ISOFORM B
P04397	p53 pathway by glucose deprivation	P04640	p53	RAT|RGD=3889|UniProtKB=P10361	Cellular tumor antigen p53	TAS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	CAEBR|Gene=CBG05858|UniProtKB=A8X1H0	Protein CBR-EGL-19 (Fragment)	ISS	91056091	PubMed	PTHR10037:SF228	VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1
P06664	Gonadotropin-releasing hormone receptor pathway	P06751	LHbeta	MOUSE|MGI=MGI=96782|UniProtKB=O09108	Lutropin subunit beta	RCA			PTHR11515:SF11	LUTROPIN SUBUNIT BETA
P00021	FGF signaling pathway	P00624	14-3-3	ANOGA|EnsemblGenome=AGAP001151|UniProtKB=Q7PX08	AGAP001151-PA	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00034	Integrin signalling pathway	P00906	Rap1	RAT|RGD=1588562|UniProtKB=D3ZK56	Protein Rap2c	ISS	8576107	PubMed	PTHR24070:SF200	RAS-RELATED PROTEIN RAP-2C
P00004	Alzheimer disease-presenilin pathway	P00158	CSL	RAT|RGD=1310557|UniProtKB=F1LNW1	Protein Rbpj	ISS	9528780	PubMed	PTHR10665:SF3	RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS
P00036	Interleukin signaling pathway	P00996	STAT	MACMU|Ensembl=ENSMMUG00000005617|UniProtKB=F6WDY6	Signal transducer and activator of transcription	ISS	12496413	PubMed	PTHR11801:SF19	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 4
P00030	Hypoxia response via HIF activation	P00819	AKT	XENTR|Xenbase=XB-GENE-484953|UniProtKB=F6XP81	Uncharacterized protein (Fragment)	ISS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	CHICK|Ensembl=ENSGALG00000004735|UniProtKB=F1NHE1	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00402	Jnk	MOUSE|MGI=MGI=1346862|UniProtKB=Q9WTU6	Mitogen-activated protein kinase 9	IDA	10207617	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	ISS	11691998	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P02770	Pyridoxal phosphate salvage pathway	P03122	Pyridoxamine kinase	CAEEL|WormBase=WBGene00019008|UniProtKB=O01824	Putative pyridoxal kinase	ISS			PTHR10534:SF2	PYRIDOXAL KINASE
P00017	DNA replication	P00536	DNA Topisomerase	RAT|RGD=1303177|UniProtKB=Q6IM78	DNA topoisomerase I, mitochondrial	ISS			PTHR10290:SF1	DNA TOPOISOMERASE I, MITOCHONDRIAL
P00046	Oxidative stress response	P01129	JNK1/2	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10441479	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00568	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	2837282	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	STRPU|EnsemblGenome=SPU_006859|UniProtKB=O44419	Synaptosomal-associated protein	IC	9070898	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00004	Alzheimer disease-presenilin pathway	P00133	alpha-catenin	DANRE|Ensembl=ENSDARG00000024785|UniProtKB=B7ZC77	Catenin alpha-2	ISS	9362521	PubMed	PTHR18914:SF29	CATENIN ALPHA-2
P00049	Parkinson disease	P01211	ERK	RAT|RGD=3046|UniProtKB=P21708	Mitogen-activated protein kinase 3	IDA	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00018	EGF receptor signaling pathway	P00548	RKIP	DANRE|ZFIN=ZDB-GENE-040426-2621|UniProtKB=Q6NYS4	Phosphatidylethanolamine binding protein	ISS			PTHR11362:SF28	PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	NEMVE|Gene=v1g88970|UniProtKB=A7RPN8	Predicted protein (Fragment)	ISS	10487978	PubMed	PTHR23050:SF245	AT16150P-RELATED
P00001	Adrenaline and noradrenaline biosynthesis	P00067	MAO	HUMAN|HGNC=6834|UniProtKB=P27338	Amine oxidase [flavin-containing] B	ISS	90344230	PubMed	PTHR43563:SF5	AMINE OXIDASE  FLAVIN-CONTAINING  B
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00057	Wnt signaling pathway	P01457	GBeta	CRYNJ|EnsemblGenome=CND03830|UniProtKB=Q5KI86	Uncharacterized protein	IDA	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MOUSE|MGI=MGI=1351338|UniProtKB=P97772	Metabotropic glutamate receptor 1	IDA	9407094	PubMed	PTHR24060:SF29	METABOTROPIC GLUTAMATE RECEPTOR 1
P00021	FGF signaling pathway	P00628	JNK1-3	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	9349820	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00004	Alzheimer disease-presenilin pathway	P00127	APP	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	11544248	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	BOVIN|Ensembl=ENSBTAG00000008323|UniProtKB=Q17QQ3	Synaptosomal-associated protein 25	ISS	12475239	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00029	Huntington disease	P00778	NMDA receptor	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	IDA	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P02784	Tyrosine biosynthesis	P03213	Aromatic amino acid aminotransferase	ARATH|TAIR=AT2G24850|UniProtKB=Q9SK47	Probable aminotransferase TAT3	ISS			PTHR11751:SF368	TYROSINE AMINOTRANSFERASE
P00005	Angiogenesis	P00243	Raf	BOVIN|Ensembl=ENSBTAG00000005039|UniProtKB=Q2KJA0	ARAF protein	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00029	Huntington disease	P00805	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DANRE|ZFIN=ZDB-GENE-040426-1178|UniProtKB=Q7SY24	Protein kinase C beta type	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00034	Integrin signalling pathway	P00922	Collagen	MOUSE|MGI=MGI=88465|UniProtKB=Q05722	Collagen alpha-1(IX) chain	IDA	10778855	PubMed	PTHR44652:SF3	COLLAGEN ALPHA-1 IX  CHAIN
P00037	Ionotropic glutamate receptor pathway	P01014	mGluR 2/3	HUMAN|HGNC=4595|UniProtKB=Q14832	Metabotropic glutamate receptor 3	ISS	12351712	PubMed	PTHR24060:SF107	METABOTROPIC GLUTAMATE RECEPTOR 3
P00019	Endothelin signaling pathway	P00566	ERK	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P02774	Salvage pyrimidine deoxyribonucleotides	P03147	Thymidine kinase	ARATH|TAIR=AT5G23070|UniProtKB=F4KBF5	Thymidine kinase b	ISS			PTHR11441:SF2	THYMIDINE KINASE B
P00056	VEGF signaling pathway	P01423	p38MAPK	MOUSE|MGI=MGI=1346865|UniProtKB=P47811	Mitogen-activated protein kinase 14	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	IC			PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00054	Toll receptor signaling pathway	P01367	MKK3	HUMAN|HGNC=6843|UniProtKB=P46734	Dual specificity mitogen-activated protein kinase kinase 3	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00706	RGS-PX1	RAT|RGD=1309778|UniProtKB=A0A0G2JUH8	Protein Snx13	ISS	11729322	PubMed	PTHR22775:SF30	SORTING NEXIN-13
P00034	Integrin signalling pathway	P00922	Collagen	RAT|RGD=1309361|UniProtKB=D4AC70	Protein Col8a1	ISS	10778855	PubMed	PTHR44057:SF2	COLLAGEN ALPHA-1 VIII  CHAIN
P00036	Interleukin signaling pathway	P00986	eNOS	CANLF|Gene=NOS3|UniProtKB=Q9TUX8	Nitric oxide synthase, endothelial	ISS	10435050	PubMed	PTHR19384:SF66	NITRIC OXIDE SYNTHASE, ENDOTHELIAL
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	HUMAN|HGNC=4398|UniProtKB=P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	RCA	11313908	PubMed	PTHR19850:SF27	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-2
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	MACMU|Ensembl=ENSMMUG00000010142|UniProtKB=F6QXD3	Uncharacterized protein	ISS	http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00047	PDGF signaling pathway	P01153	GSK3	BOVIN|Ensembl=ENSBTAG00000020756|UniProtKB=A6QLB8	GSK3A protein	ISS	12086949	PubMed	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P00012	Cadherin signaling pathway	P00466	EGFR	MACMU|Ensembl=ENSMMUG00000001674|UniProtKB=F7G3H1	Receptor protein-tyrosine kinase	ISS	4885215	gi	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	RAT|RGD=61993|UniProtKB=Q99JE6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	IDA	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	ANOGA|EnsemblGenome=AGAP001384|UniProtKB=Q7PXF7	AGAP001384-PA	IC	14744463	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=19218|UniProtKB=Q86YW0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1	ISS	7822322	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P00005	Angiogenesis	P00219	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00019	Endothelin signaling pathway	P00568	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	7513693	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	IC	8026589	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00006	Apoptosis signaling pathway	P00299	Caspase 8	CHICK|Ensembl=ENSGALG00000008355|UniProtKB=F1NXP6	Uncharacterized protein	ISS	11788820	PubMed	PTHR10454:SF162	CASPASE-8
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	DANRE|ZFIN=ZDB-GENE-040426-1178|UniProtKB=Q7SY24	Protein kinase C beta type	ISS	11880265	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00059	p53 pathway	P01486	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	11387345	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00175	GSK-3beta	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00710	Gbeta	SCLS1|EnsemblGenome=SS1G_03482|UniProtKB=A7EDU2	Guanine nucleotide-binding protein beta subunit	ISS	11313908	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00030	Hypoxia response via HIF activation	P00825	Thioredoxin	PSEAE|EnsemblGenome=PA5240|UniProtKB=Q9X2T1	Thioredoxin	ISS			PTHR10438:SF215	THIOREDOXIN DOMAIN-CONTAINING PROTEIN, MITOCHONDRIAL
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00021	FGF signaling pathway	P00632	Akt	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12843127	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	632169	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	MOUSE|MGI=MGI=99260|UniProtKB=Q62074	Protein kinase C iota type	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P05913	Enkephalin release	P05977	G-Protein (s)	MACMU|Ensembl=ENSMMUG00000001896|UniProtKB=F7FXA9	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00048	PI3 kinase pathway	P01177	P110ACT	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	14605019	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	PANTR|Gene=DVL1|UniProtKB=Q5IS48	Segment polarity protein dishevelled homolog DVL-1	ISS	7906389	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P00053	T cell activation	P01311	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	P11345	SPACC	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01444	Wnt	BOVIN|Ensembl=ENSBTAG00000020221|UniProtKB=E1BDG5	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	IDA	10644715	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00010	B cell activation	P00402	Jnk	HUMAN|HGNC=6881|UniProtKB=P45983	Mitogen-activated protein kinase 8	IDA	10797012	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00019	Endothelin signaling pathway	P00589	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00714	GSK	MACMU|Ensembl=ENSMMUG00000014597|UniProtKB=F6VAQ6	Glycogen synthase kinase-3 alpha	ISS	11995474	gi	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA
P02774	Salvage pyrimidine deoxyribonucleotides	P03147	Thymidine kinase	MOUSE|MGI=MGI=98763|UniProtKB=P04184	Thymidine kinase, cytosolic	ISS			PTHR11441:SF0	THYMIDINE KINASE, CYTOSOLIC
P00006	Apoptosis signaling pathway	P00318	PKCs	HUMAN|HGNC=9399|UniProtKB=Q05655	Protein kinase C delta type	IDA	3045562	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00029	Huntington disease	P00810	GAPDH	THAPS|Gene=Thaps31383|UniProtKB=B8BQU2	Glyceraldehyde-3-phosphate dehydrogenase (Fragment)	ISS			PTHR10836:SF52	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED
P00004	Alzheimer disease-presenilin pathway	P00148	Erb-B4 N-terminal fragment	RAT|RGD=620486|UniProtKB=Q62956	Receptor tyrosine-protein kinase erbB-4	IDA	11679632	PubMed	PTHR24416:SF90	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4
P00052	TGF-beta signaling pathway	P01275	P38	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	BOVIN|Ensembl=ENSBTAG00000002767|UniProtKB=A5PKD6	GNB4 protein	ISS	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DANRE|ZFIN=ZDB-GENE-000330-4|UniProtKB=Q1MTI1	Uncharacterized protein	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00053	T cell activation	P01307	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	9217262	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04378	Beta2 adrenergic receptor signaling pathway	P04442	SNARE Complex	MACMU|Ensembl=ENSMMUG00000021801|UniProtKB=Q9N0Y0	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00059	p53 pathway	P01486	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	14520710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00004	Alzheimer disease-presenilin pathway	P00114	actin	RAT|RGD=1304556|UniProtKB=P63259	Actin, cytoplasmic 2	ISS	14684598	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00056	VEGF signaling pathway	P01407	Erk	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00641	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	BOVIN|Ensembl=ENSBTAG00000020921|UniProtKB=P05126	Protein kinase C beta type	IDA	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	1707501	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	MONDO|Ensembl=ENSMODG00000001404|UniProtKB=F7BD74	Uncharacterized protein	ISS	10207617	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00021	FGF signaling pathway	P00633	Ras	MONDO|Ensembl=ENSMODG00000004590|UniProtKB=Q95ME4	GTPase NRas	ISS	12104050	PubMed	PTHR24070:SF189	GTPASE NRAS
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	1322797	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P02739	De novo pyrimidine deoxyribonucleotide biosynthesis	P02915	CDP Reductase	YEAST|SGD=S000003563|UniProtKB=P09938	Ribonucleoside-diphosphate reductase small chain 1	ISS			PTHR23409:SF18	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00049	Parkinson disease	P01227	20S proteasome	ANOGA|EnsemblGenome=AGAP001973|UniProtKB=F5HMB0	Proteasome subunit alpha type	TAS	12859888	PubMed	PTHR11599:SF10	PROTEASOME SUBUNIT ALPHA TYPE-3
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MOUSE|MGI=MGI=98959|UniProtKB=P22726	Protein Wnt-5b	TAS	11266476	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00046	Oxidative stress response	P01136	Elk-1	MOUSE|MGI=MGI=101833|UniProtKB=P41969	ETS domain-containing protein Elk-1	TAS	11050086	PubMed	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P02726	Aminobutyrate degradation	P02824	Succinate semi-aldehyde dehydrogenase	NEUCR|Gene=NCU00936|UniProtKB=V5IQD0	Succinate semialdehyde dehydrogenase	ISS	12891648	PubMed	PTHR43353:SF5	SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	CANLF|Ensembl=ENSCAFG00000008396|UniProtKB=F1P9Z4	Uncharacterized protein	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	14526383	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	CANLF|Ensembl=ENSCAFG00000012181|UniProtKB=F2Z4N7	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P00022	General transcription by RNA polymerase I	P00657	TBP	XENTR|Xenbase=XB-GENE-876138|UniProtKB=Q28DH2	TATA box-binding protein-like protein 2	ISS	600075	OMIM	PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00023	General transcription regulation	P00668	TFIIB	DROME|FlyBase=FBgn0032248|UniProtKB=Q9VKV8	Cilia- and flagella-associated protein 20	ISS			PTHR12458:SF8	CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20
P00053	T cell activation	P01318	PKC-theta	CANLF|Ensembl=ENSCAFG00000005169|UniProtKB=E2RNP2	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00005	Angiogenesis	P00188	Ets	XENTR|Xenbase=XB-GENE-6465484|UniProtKB=B3DM35	LOC100170599 protein	ISS	2205841	PubMed	PTHR11849:SF209	PROTEIN C-ETS-1
P00005	Angiogenesis	P00203	Erk	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	9261178	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00036	Interleukin signaling pathway	P00965	ERK	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	9836510	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00049	Parkinson disease	P01227	20S proteasome	PANTR|Ensembl=ENSPTRG00000018826|UniProtKB=H2QU28	Proteasome subunit beta type	ISS	12859888	PubMed	PTHR11599:SF59	PROTEASOME SUBUNIT BETA TYPE-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	ISS	12660731	PubMed	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00056	VEGF signaling pathway	P01425	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IDA	12782715	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00018	EGF receptor signaling pathway	P00539	14-3-3	RAT|RGD=3980|UniProtKB=P63102	14-3-3 protein zeta/delta	ISS	92362864	PubMed	PTHR18860:SF7	14-3-3 PROTEIN ZETA/DELTA
P00010	B cell activation	P00398	IP3R	RAT|RGD=2933|UniProtKB=P29994	Inositol 1,4,5-trisphosphate receptor type 1	IGI	2165071	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00037	Ionotropic glutamate receptor pathway	P01008	NR2A	RAT|RGD=2737|UniProtKB=Q00959	Glutamate receptor ionotropic, NMDA 2A	ISS	http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html	Website	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P02743	Formyltetrahydroformate biosynthesis	P02952	Methylene tetrahydrofolate dehydrogenase	IXOSC|EnsemblGenome=ISCW016713|UniProtKB=B7P898	C1-tetrahydrofolate synthase, putative (Fragment)	ISS			PTHR10025:SF57	DAUER OR AGING ADULT OVEREXPRESSION
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	CAEEL|WormBase=WBGene00001196|UniProtKB=G5EGU1	EGL-30	ISS	8457205	PubMed	PTHR10218:SF295	G PROTEIN ALPHA Q SUBUNIT-RELATED
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00053	T cell activation	P01300	ERK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	1533654	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01085	G-Protein	TAKRU|Ensembl=ENSTRUG00000007037|UniProtKB=H2SY00	Uncharacterized protein	ISS	15860573	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	DANRE|ZFIN=ZDB-GENE-040426-1310|UniProtKB=Q7T3D3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	RCA			PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00034	Integrin signalling pathway	P00941	Integrin alpha	PANTR|Ensembl=ENSPTRG00000016859|UniProtKB=H2QQV4	Integrin, alpha 1	ISS	3487386	PubMed	PTHR23220:SF22	INTEGRIN ALPHA-1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	CANLF|Ensembl=ENSCAFG00000015138|UniProtKB=F1PRG8	Uncharacterized protein	ISS	10414292	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00021	FGF signaling pathway	P00644	p38	RAT|RGD=3045|UniProtKB=Q9WTY9	Mitogen-activated protein kinase 13	IGI	11790551	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00898	FKHR	BOVIN|Ensembl=ENSBTAG00000011234|UniProtKB=F1N4K5	Uncharacterized protein	ISS	15031210	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	XENTR|Xenbase=XB-GENE-5898446|UniProtKB=Q1ECU1	MGC146599 protein	ISS			PTHR23431:SF3	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5
P00018	EGF receptor signaling pathway	P00557	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	10799299	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	ORNAN|Ensembl=ENSOANG00000001563|UniProtKB=F7G7I9	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=19218|UniProtKB=Q86YW0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1	ISS	15611108	PubMed	PTHR10336:SF29	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
P00021	FGF signaling pathway	P00647	SHP2	CHICK|Ensembl=ENSGALG00000004821|UniProtKB=Q90687	Tyrosine-protein phosphatase non-receptor type 11	ISS	8096088	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	ORNAN|Ensembl=ENSOANG00000007405|UniProtKB=F7CIV4	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF353	SUBFAMILY NOT NAMED
P00060	Ubiquitin proteasome pathway	P01491	E2	XENTR|Xenbase=XB-GENE-1003709|UniProtKB=Q6DDC8	Ubiquitin-conjugating enzyme E2B (RAD6 homolog)	ISS			PTHR43898:SF6	UBIQUITIN-CONJUGATING ENZYME E2 B
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	HUMAN|HGNC=15917|UniProtKB=Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00034	Integrin signalling pathway	P00936	PI3K	MACMU|Ensembl=ENSMMUG00000003162|UniProtKB=F7EP57	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	11278468	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00020	FAS signaling pathway	P00601	c-Jun	RAT|RGD=2943|UniProtKB=P17325	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P02746	Heme biosynthesis	P02975	Uroporphyrinogen decarboxylase	ARATH|TAIR=AT3G14930|UniProtKB=Q93ZB6	Uroporphyrinogen decarboxylase 1, chloroplastic	ISS			PTHR21091:SF2	UROPORPHYRINOGEN DECARBOXYLASE
P02738	De novo purine biosynthesis	P02909	GDP reductase	CANLF|Ensembl=ENSCAFG00000003409|UniProtKB=E2R7H9	Uncharacterized protein	ISS			PTHR23409:SF20	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2
P00006	Apoptosis signaling pathway	P00269	MAPK	ORYSJ|EnsemblGenome=OS06G0154500|UniProtKB=Q84UI5	Mitogen-activated protein kinase 1	ISS	9836510	gi	PTHR24055:SF325	MITOGEN-ACTIVATED PROTEIN KINASE 10-RELATED
P00018	EGF receptor signaling pathway	P00557	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	97334438	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00981	SOS	CHICK|Ensembl=ENSGALG00000013224|UniProtKB=F1NMA4	Uncharacterized protein	ISS	8479536	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	CAEBR|Gene=CBG09569|UniProtKB=A8X8S6	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P02775	Salvage pyrimidine ribonucleotides	P03153	Cytidylate kinase	CHICK|Ensembl=ENSGALG00000010481|UniProtKB=Q5ZKE7	UMP-CMP kinase	ISS			PTHR23359:SF107	UMP-CMP KINASE
P02727	Androgen/estrogene/progesterone biosynthesis	P02835	Cholesterol monooxygenase	CHICK|Ensembl=ENSGALG00000001417|UniProtKB=F1NIZ4	Uncharacterized protein	ISS	2235974	PubMed	PTHR24279:SF3	CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME, MITOCHONDRIAL
P00018	EGF receptor signaling pathway	P00558	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	IPI	8621483	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	PANTR|Ensembl=ENSPTRG00000018059|UniProtKB=C7G3M9	Glutamate receptor, metabotropic 4	ISS	12488551	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00029	Huntington disease	P00777	CBP	MACMU|Ensembl=ENSMMUG00000002286|UniProtKB=F6RRA8	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00046	Oxidative stress response	P01135	p38	CANLF|Ensembl=ENSCAFG00000001382|UniProtKB=E2RKA7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00036	Interleukin signaling pathway	P00976	GSK3	CANLF|Ensembl=ENSCAFG00000011122|UniProtKB=E2RB53	Uncharacterized protein	ISS	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	CANLF|Ensembl=ENSCAFG00000002617|UniProtKB=E2QUL1	Uncharacterized protein	ISS	http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm	Website	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00838	AP-1	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04585	TRH	MACMU|Ensembl=ENSMMUG00000005160|UniProtKB=F7D5R6	Uncharacterized protein	ISS	2126343	PubMed	PTHR17530:SF2	PRO-THYROTROPIN-RELEASING HORMONE
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	90172230	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000021127|UniProtKB=P38408	Guanine nucleotide-binding protein subunit alpha-14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00034	Integrin signalling pathway	P00938	Cdc42	TAKRU|Ensembl=ENSTRUG00000008289|UniProtKB=H2T7U8	Uncharacterized protein	ISS	11027488	PubMed	PTHR24072:SF129	CDC42L PROTEIN
P00021	FGF signaling pathway	P00648	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	IGI	21157398	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P00006	Apoptosis signaling pathway	P00317	Fos	TAKRU|Ensembl=ENSTRUG00000010579|UniProtKB=H2TPU7	Uncharacterized protein	ISS	12056584	gi	PTHR23351:SF4	PROTO-ONCOGENE C-FOS
P02772	Pyruvate metabolism	P03132	Pyruvate Kinase	ARATH|TAIR=AT3G55650|UniProtKB=Q9M057	Pyruvate kinase	TAS	15228164	gi	PTHR11817:SF34	PYRUVATE KINASE
P00019	Endothelin signaling pathway	P00568	PKC	MOUSE|MGI=MGI=97598|UniProtKB=P28867	Protein kinase C delta type	ISS	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01073	G-Protein	HUMAN|HGNC=4396|UniProtKB=P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC			PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00021	FGF signaling pathway	P00644	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	ISS	11707292	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00059	p53 pathway	P01486	Akt	MONDO|Ensembl=ENSMODG00000006626|UniProtKB=F7GEK1	Uncharacterized protein	ISS	10208883	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	88248054	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00047	PDGF signaling pathway	P01167	Ets	BOVIN|Ensembl=ENSBTAG00000017150|UniProtKB=Q32LN0	ETS homologous factor	ISS	15298723	PubMed	PTHR11849:SF171	ETS HOMOLOGOUS FACTOR
P05913	Enkephalin release	P05974	G-Protein (i)	HUMAN|HGNC=4387|UniProtKB=P08754	Guanine nucleotide-binding protein G(k) subunit alpha	IC	15521358	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00924	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	11933072	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	IC	14570579	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00018	EGF receptor signaling pathway	P00552	Ras	CHICK|Ensembl=ENSGALG00000014033|UniProtKB=E1BTS2	Uncharacterized protein	ISS	7997267	PubMed	PTHR24070:SF186	GTPASE KRAS
P00018	EGF receptor signaling pathway	P00540	MKK3,6	MONDO|Ensembl=ENSMODG00000001404|UniProtKB=F7BD74	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00015	Circadian clock system	P00505	Cry	MACMU|Ensembl=ENSMMUG00000002453|UniProtKB=F7HH05	Cryptochrome-2	ISS	10217146	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00048	PI3 kinase pathway	P01188	Gbetagamma	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC	10391901	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04380	Cortocotropin releasing factor receptor signaling pathway	G04671	proopiomelanocortin	MACMU|Ensembl=ENSMMUG00000016463|UniProtKB=F7GBI0	Uncharacterized protein	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANLF|Ensembl=ENSCAFG00000015640|UniProtKB=E2QVF3	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	DANRE|ZFIN=ZDB-GENE-040426-1354|UniProtKB=Q7T2C5	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	11032873	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00002	Alpha adrenergic receptor signaling pathway	P00077	G-Protein	BOVIN|Ensembl=ENSBTAG00000012181|UniProtKB=P38409	Guanine nucleotide-binding protein subunit alpha-11	ISS	8838318	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00010	B cell activation	P00371	ERK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=95769|UniProtKB=P30677	Guanine nucleotide-binding protein subunit alpha-14	IC	8457205	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00021	FGF signaling pathway	P00644	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IGI	9218798	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00049	Parkinson disease	P01208	Hsp70	DROME|FlyBase=FBgn0013277|UniProtKB=Q8INI8	Major heat shock 70 kDa protein Ba	IDA	12150907	PubMed	PTHR19375:SF256	HSP70 PROTEIN-RELATED
P00059	p53 pathway	P04609	PI3K	SCHPO|PomBase=SPAC458.05|UniProtKB=P50520	Phosphatidylinositol 3-kinase vps34	ISS	7937853	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PANTR|Ensembl=ENSPTRG00000002086|UniProtKB=H2Q1A9	Uncharacterized protein	ISS	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P00020	FAS signaling pathway	P00608	Pro-Caspase3	CANLF|Ensembl=ENSCAFG00000007750|UniProtKB=Q8MKI5	Caspase-3	IGI	11675509	PubMed	PTHR10454:SF198	CASPASE-3
P00059	p53 pathway	P01486	Akt	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	TAS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	RAT|RGD=1308423|UniProtKB=D3ZY89	Protein Taf8	ISS	604904	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00006	Apoptosis signaling pathway	P00310	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IDA	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00862	PKA	HUMAN|HGNC=9382|UniProtKB=P22612	cAMP-dependent protein kinase catalytic subunit gamma	ISS	1319556	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00048	PI3 kinase pathway	G01544	GADD45	MACMU|Ensembl=ENSMMUG00000014808|UniProtKB=F6W540	Growth arrest and DNA damage-inducible protein GADD45 alpha isoform 1	ISS	10097101	PubMed	PTHR10411:SF3	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA
P00056	VEGF signaling pathway	P01425	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	22533439	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00046	Oxidative stress response	P01129	JNK1/2	MONDO|Ensembl=ENSMODG00000003946|UniProtKB=F6WV79	Mitogen-activated protein kinase	ISS	15572687	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00034	Integrin signalling pathway	P00925	MEK	BOVIN|Ensembl=ENSBTAG00000012103|UniProtKB=A5PJP8	MAP2K4 protein	ISS	11730323	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00040	Metabotropic glutamate receptor group II pathway	P01049	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P06664	Gonadotropin-releasing hormone receptor pathway	P06779	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	RCA	14707121	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	RAT|RGD=3948|UniProtKB=Q63666	Vesicle-associated membrane protein 1	IC	8011337	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9390|UniProtKB=P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	IC	188830	OMIM	PTHR11635:SF126	CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT
P00049	Parkinson disease	P01239	Cul-1	DROME|FlyBase=FBgn0015509|UniProtKB=Q24311	Cullin homolog 1	IDA	12628165	PubMed	PTHR11932:SF81	CULLIN-1
P00049	Parkinson disease	P01236	Casein kinase II	ARATH|TAIR=AT2G23080|UniProtKB=O64817	Probable casein kinase II subunit alpha	IDA	10617630	PubMed	PTHR24054:SF0	CASEIN KINASE II SUBUNIT ALPHA
P04374	5HT2 type receptor mediated signaling pathway	P04412	PLC	HUMAN|HGNC=9065|UniProtKB=P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	ISS	2167438	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000007230|UniProtKB=F7EG23	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00028	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction	P00755	Calmodulin	NEMVE|EnsemblGenome=NEMVEDRAFT_v1g239788|UniProtKB=A7RPI8	Predicted protein	ISS	9753452	PubMed	PTHR23050:SF245	AT16150P-RELATED
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	10414292	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P05916	Opioid prodynorphin pathway	P06002	G-protein	MONDO|Ensembl=ENSMODG00000001975|UniProtKB=F6RIM7	Uncharacterized protein (Fragment)	ISS	8327893	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00020	FAS signaling pathway	P00614	ASK1	BOVIN|Ensembl=ENSBTAG00000009065|UniProtKB=F1MXH6	Uncharacterized protein	TAS			PTHR11584:SF332	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	HUMAN|HGNC=4585|UniProtKB=Q12879	Glutamate receptor ionotropic, NMDA 2A	ISS	11319238	PubMed	PTHR43958:SF6	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A
P02751	Lysine biosynthesis	P03008	Dihydrodipicolinate synthase	ECOLI|EcoGene=EG12550|UniProtKB=P39359	Uncharacterized lyase YjhH	ISS			PTHR12128:SF28	2-KETO-3-DEOXY-GALACTONATE ALDOLASE YAGE-RELATED
P00029	Huntington disease	P00780	Microtubule	BOVIN|Ensembl=ENSBTAG00000025274|UniProtKB=Q3MHM5	Tubulin beta-4B chain	ISS	12932731	PubMed	PTHR11588:SF247	TUBULIN BETA-4B CHAIN
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05933	PLC	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	RCA	10934033	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	RAT|RGD=621514|UniProtKB=Q3KRE3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00048	PI3 kinase pathway	P01179	PKB	PANTR|Ensembl=ENSPTRG00000002174|UniProtKB=H2R7Z0	Uncharacterized protein	ISS	12663464	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01456	beta-arrestin	MOUSE|MGI=MGI=98227|UniProtKB=P20443	S-arrestin	IC	11742073	PubMed	PTHR11792:SF15	S-ARRESTIN
P00036	Interleukin signaling pathway	P00985	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00053	T cell activation	P01312	MEK	CHICK|Gene=MAP2K2|UniProtKB=Q90891	Dual specificity mitogen-activated protein kinase kinase 2	IDA	11238629	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00053	T cell activation	P01322	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IGI	11756681	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00022	General transcription by RNA polymerase I	P00657	TBP	LEIMA|EnsemblGenome=LmjF.19.1390|UniProtKB=Q4QD71	Transcription initiation factor-like protein (TFIID-like protein)	ISS			PTHR10126:SF6	TATA BOX BINDING PROTEIN-LIKE 2-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	HUMAN|HGNC=1029|UniProtKB=P46663	B1 bradykinin receptor	IDA	12130679	PubMed	PTHR24228:SF28	B1 BRADYKININ RECEPTOR
P00019	Endothelin signaling pathway	P00566	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10875333	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00059	p53 pathway	P04609	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01306	Ras	RAT|RGD=3205|UniProtKB=Q04970	GTPase NRas	IDA	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00019	Endothelin signaling pathway	P00572	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	ISS	94313981	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	MOUSE|MGI=MGI=97513|UniProtKB=P23188	Furin	IDA	11861638	PubMed	PTHR42884:SF1	FURIN
P05731	GABA-B receptor II signaling	P05754	Ggamma	MACMU|Ensembl=ENSMMUG00000002438|UniProtKB=F6PKY3	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-T2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00057	Wnt signaling pathway	P01444	Wnt	PANTR|Ensembl=ENSPTRG00000009321|UniProtKB=H2QD96	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF82	PROTO-ONCOGENE WNT-3
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	XENTR|Xenbase=XB-GENE-942565|UniProtKB=F6UBJ8	Synaptosomal-associated protein (Fragment)	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04674	Mdm2	RAT|RGD=1309306|UniProtKB=Q5XIN1	Protein Mdm4	ISS			PTHR13844:SF20	PROTEIN MDM4
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	CANLF|Ensembl=ENSCAFG00000012181|UniProtKB=F2Z4N7	Uncharacterized protein	ISS	10974003	PubMed	PTHR11937:SF176	ACTIN, ALPHA CARDIAC MUSCLE 1
P02751	Lysine biosynthesis	P03009	Aspartokinase	YEAST|SGD=S000003900|UniProtKB=P31116	Homoserine dehydrogenase	ISS			PTHR43070:SF3	HOMOSERINE DEHYDROGENASE
P00034	Integrin signalling pathway	P00936	PI3K	DICDI|dictyBase=DDB_G0278727|UniProtKB=P54673	Phosphatidylinositol 3-kinase 1	IPI	7565716	PubMed	PTHR10048:SF93	PHOSPHATIDYLINOSITOL 3-KINASE 1
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	BOVIN|Ensembl=ENSBTAG00000002508|UniProtKB=P63214	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	ISS	9754712	PubMed	PTHR13809:SF11	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-3
P04378	Beta2 adrenergic receptor signaling pathway	P04445	Ca2+ channel	MOUSE|MGI=MGI=88294|UniProtKB=Q02789	Voltage-dependent L-type calcium channel subunit alpha-1S	ISS	8838325	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00044	Nicotinic acetylcholine receptor signaling pathway	P01088	alpha	XENTR|Xenbase=XB-GENE-977139|UniProtKB=F6RLA9	Uncharacterized protein	ISS	85270494	PubMed	PTHR18945:SF74	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA
P00034	Integrin signalling pathway	P00922	Collagen	MONDO|Ensembl=ENSMODG00000018507|UniProtKB=F7AGY1	Uncharacterized protein	ISS	10778855	PubMed	PTHR45047:SF2	COLLAGEN ALPHA-1 XII  CHAIN
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IDA	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P06216	SCW signaling pathway	P06333	FUR1	DROME|FlyBase=FBgn0004509|UniProtKB=P26016	Furin-like protease 1, isoforms 1/1-X/2	IEA	10956649	PubMed	PTHR42884:SF3	FURIN-LIKE PROTEASE 1, ISOFORMS 1/1-X/2
P00019	Endothelin signaling pathway	P00589	Akt	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IGI	12062094	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P02773	S-adenosylmethionine biosynthesis	P03142	Cobalamin-dependent homocysteine transmethylase	BOVIN|Gene=MTR|UniProtKB=Q4JIJ3	Methionine synthase	ISS			PTHR21091:SF97	METHIONINE SYNTHASE
P00056	VEGF signaling pathway	P01415	MAPKAPK2/3	PANTR|Ensembl=ENSPTRG00000001915|UniProtKB=H2Q104	Mitogen-activated protein kinase-activated protein kinase 2	ISS	7923354	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P00059	p53 pathway	P04630	PP2A	DANRE|ZFIN=ZDB-GENE-040426-877|UniProtKB=F1Q6Z7	Serine/threonine-protein phosphatase	ISS	11983168	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P00005	Angiogenesis	P00206	Wnt	MONDO|Ensembl=ENSMODG00000018415|UniProtKB=F6XUZ7	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00048	PI3 kinase pathway	P01188	Gbetagamma	RAT|RGD=2718|UniProtKB=P54311	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	IC	6264430	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	CANLF|Ensembl=ENSCAFG00000003952|UniProtKB=E2RRA1	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00049	Parkinson disease	P01211	ERK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	11251832	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	HUMAN|HGNC=1397|UniProtKB=Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	IC	15621031	PubMed	PTHR10037:SF190	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04675	PTEN	BOVIN|Ensembl=ENSBTAG00000009498|UniProtKB=F1MDX9	Uncharacterized protein	ISS	hCP40693	gi	PTHR12305:SF81	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN
P00006	Apoptosis signaling pathway	P00260	AKT	ANOGA|EnsemblGenome=AGAP002161|UniProtKB=Q7QK56	AGAP002161-PA	ISS	12089061	PubMed	PTHR24356:SF216	RAC SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	11007872	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00054	Toll receptor signaling pathway	P01360	IKKbeta	BOVIN|Ensembl=ENSBTAG00000007599|UniProtKB=Q95KV0	Inhibitor of nuclear factor kappa-B kinase subunit beta	ISS	12235208	PubMed	PTHR22969:SF7	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA
P00009	Axon guidance mediated by netrin	P00364	cdc42	IXOSC|EnsemblGenome=ISCW003614|UniProtKB=B7PHY7	Cdc42 protein, putative	ISS	4757952	gi	PTHR24072:SF192	CDC42 HOMOLOG
P00016	Cytoskeletal regulation by Rho GTPase	P00517	PAK	BOVIN|Ensembl=ENSBTAG00000047856|UniProtKB=G3MZE2	Uncharacterized protein	ISS	8626411	PubMed	PTHR24361:SF281	SERINE/THREONINE-PROTEIN KINASE PAK 2
P00049	Parkinson disease	P01219	SAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	12358800	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00049	Parkinson disease	P01239	Cul-1	SCHPO|PomBase=SPAC17G6.12|UniProtKB=O13790	Cullin-1	IDA	12628165	PubMed	PTHR11932:SF81	CULLIN-1
P00020	FAS signaling pathway	P00610	MKK4	HUMAN|HGNC=6844|UniProtKB=P45985	Dual specificity mitogen-activated protein kinase kinase 4	TAS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00863	EMC	MACMU|Ensembl=ENSMMUG00000014049|UniProtKB=F7AG82	Uncharacterized protein	ISS	10778855	PubMed	PTHR44105:SF2	COLLAGEN ALPHA-3 VI  CHAIN
P00018	EGF receptor signaling pathway	P00540	MKK3,6	CHICK|Ensembl=ENSGALG00000004735|UniProtKB=F1NHE1	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00012	Cadherin signaling pathway	P00475	Frizzled	HUMAN|HGNC=4047|UniProtKB=O00144	Frizzled-9	IDA	8717036	PubMed	PTHR11309:SF79	FRIZZLED-9
P00059	p53 pathway	G04691	IGF-BP3	BOVIN|Ensembl=ENSBTAG00000003994|UniProtKB=P20959	Insulin-like growth factor-binding protein 3	ISS			PTHR11551:SF3	INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 3
P00054	Toll receptor signaling pathway	P01375	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	ISS	10514528	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05954	Gbeta	CHICK|Ensembl=ENSGALG00000008983|UniProtKB=E1BW98	Uncharacterized protein	ISS	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00048	PI3 kinase pathway	P01177	P110ACT	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00012	Cadherin signaling pathway	P00474	Wnt	MACMU|Ensembl=ENSMMUG00000015705|UniProtKB=F6SM00	Protein Wnt	ISS	12549854	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12507995	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00023	General transcription regulation	P00666	TFIIE	DROME|FlyBase=FBgn0015829|UniProtKB=O96881	Transcription initiation factor IIE subunit beta	ISS	189962	OMIM	PTHR12716:SF8	TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA
P00059	p53 pathway	P04612	HDAC1	MOUSE|MGI=MGI=108086|UniProtKB=O09106	Histone deacetylase 1	IDA	12665570	PubMed	PTHR10625:SF109	HISTONE DEACETYLASE 1
P00005	Angiogenesis	P00236	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	12213821	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MACMU|Ensembl=ENSMMUG00000023046|UniProtKB=F6V829	Uncharacterized protein	ISS	12488551	PubMed	PTHR24060:SF23	METABOTROPIC GLUTAMATE RECEPTOR 4
P00010	B cell activation	P00391	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	10799299	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00719	cAMP cyclase	HUMAN|HGNC=235|UniProtKB=Q8NFM4	Adenylate cyclase type 4	ISS	9870949	PubMed	PTHR11920:SF286	ADENYLATE CYCLASE TYPE 4
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00732	Gqalpha	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	8836152	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00056	VEGF signaling pathway	P01414	PLC-gamma	MONDO|Ensembl=ENSMODG00000015196|UniProtKB=F7BVQ1	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P00034	Integrin signalling pathway	P00924	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12411479	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00891	MEK	BOVIN|Ensembl=ENSBTAG00000024450|UniProtKB=Q17QH2	MAP2K2 protein	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	HUMAN|HGNC=9441|UniProtKB=P51817	cAMP-dependent protein kinase catalytic subunit PRKX	IC	10553940	PubMed	PTHR24353:SF83	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01385	TBP-associated factors	MONDO|Ensembl=ENSMODG00000003943|UniProtKB=F7FZ67	Uncharacterized protein	ISS			PTHR15137:SF9	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000016244|UniProtKB=H2QPU2	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04385	Histamine H1 receptor mediated signaling pathway	P04484	PLC	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	9305844	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04393	Ras Pathway	P04556	Raf	HUMAN|HGNC=1097|UniProtKB=P15056	Serine/threonine-protein kinase B-raf	IDA	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00010	B cell activation	P00381	Raf	PANTR|Ensembl=ENSPTRG00000014635|UniProtKB=H2QM30	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00006	Apoptosis signaling pathway	P00269	MAPK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	IDA	9836510	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00039	Metabotropic glutamate receptor group III pathway	P01046	A/K	PANTR|Ensembl=ENSPTRG00000011042|UniProtKB=H2QGF5	Uncharacterized protein	ISS	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00005	Angiogenesis	P00206	Wnt	HUMAN|HGNC=16265|UniProtKB=Q9H1J7	Protein Wnt-5b	ISS	11266476	PubMed	PTHR12027:SF87	PROTEIN WNT-5B
P00034	Integrin signalling pathway	P00912	Arp2/3	RAT|RGD=2155|UniProtKB=O88656	Actin-related protein 2/3 complex subunit 1B	IPI	9618202	PubMed	PTHR10709:SF10	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1B
P00034	Integrin signalling pathway	P00927	Rac	DICDI|dictyBase=DDB_G0268622|UniProtKB=P34145	Rho-related protein rac1B	IGI	4757952	gi	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P00054	Toll receptor signaling pathway	P01375	JNK	ORNAN|Ensembl=ENSOANG00000010228|UniProtKB=F7B5L8	Mitogen-activated protein kinase (Fragment)	ISS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00004	Alzheimer disease-presenilin pathway	P00143	TCF/LEF	XENTR|Xenbase=XB-GENE-485517|UniProtKB=F6WCX0	Uncharacterized protein	ISS	11266476	PubMed	PTHR10373:SF11	LYMPHOID ENHANCER-BINDING FACTOR 1
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00870	IL2	PANTR|Ensembl=ENSPTRG00000016418|UniProtKB=H2QQ44	Uncharacterized protein	RCA			PTHR45426:SF1	INTERLEUKIN-2
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	HUMAN|HGNC=7883|UniProtKB=Q9UM47	Neurogenic locus notch homolog protein 3	IDA	12673204	PubMed	PTHR43959:SF3	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3
P02738	De novo purine biosynthesis	P02891	GDP kinase	ORYSJ|EnsemblGenome=OS07G0492000|UniProtKB=Q07661	Nucleoside diphosphate kinase 1	ISS			PTHR11349:SF66	SUBFAMILY NOT NAMED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	ISS	12954613	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00048	PI3 kinase pathway	P01188	Gbetagamma	PANTR|Ensembl=ENSPTRG00000004592|UniProtKB=H2R3A6	Uncharacterized protein	ISS	6309843	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00023	General transcription regulation	P00658	TBP-associated factors	MACMU|Ensembl=ENSMMUG00000021944|UniProtKB=F6T3U2	Transcription initiation factor TFIID subunit 7	ISS			PTHR12228:SF6	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 7
P00057	Wnt signaling pathway	P01428	Frizzled	XENTR|Xenbase=XB-GENE-483731|UniProtKB=Q5BL72	Frizzled-7	ISS	8717036	PubMed	PTHR11309:SF31	FRIZZLED-7
P02775	Salvage pyrimidine ribonucleotides	P03150	Uridine kinase	DROME|FlyBase=FBgn0263398|UniProtKB=Q9VC99	Probable uridine-cytidine kinase	ISS			PTHR10285:SF70	URIDINE-CYTIDINE KINASE 2
P00036	Interleukin signaling pathway	P00973	PKB	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	14526383	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00034	Integrin signalling pathway	P00936	PI3K	BOVIN|Ensembl=ENSBTAG00000018984|UniProtKB=E1BE66	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00005	Angiogenesis	P00205	GAP	HUMAN|HGNC=9871|UniProtKB=P20936	Ras GTPase-activating protein 1	IDA	8270251	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P02738	De novo purine biosynthesis	P02911	N5-carboxyaminoimidazole ribonucleotide mutase	DEIRA|EnsemblGenome=DR_0023|UniProtKB=Q9RYC7	N5-carboxyaminoimidazole ribonucleotide mutase	ISS			PTHR23046:SF2	N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE MUTASE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	10514528	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00011	Blood coagulation	P00443	Fibrin polymer cross-linked	MACMU|Ensembl=ENSMMUG00000021304|UniProtKB=F6UYY8	Uncharacterized protein	ISS	80015086	PubMed	PTHR19143:SF338	FIBRINOGEN GAMMA CHAIN
P04398	p53 pathway feedback loops 2	G04707	P110ALPHA	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01161	Raf	MOUSE|MGI=MGI=88190|UniProtKB=P28028	Serine/threonine-protein kinase B-raf	ISS	8576107	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	10218114	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00018	EGF receptor signaling pathway	P00549	EGF	HUMAN|HGNC=3443|UniProtKB=O14944	Proepiregulin	ISS			PTHR10740:SF11	PROEPIREGULIN
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	XENTR|Xenbase=XB-GENE-944497|UniProtKB=F6THW2	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00629	PP2A	MONDO|Ensembl=ENSMODG00000019001|UniProtKB=F7CP86	Serine/threonine-protein phosphatase	ISS	88083628	PubMed	PTHR11668:SF301	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
P00019	Endothelin signaling pathway	P00568	PKC	DANRE|ZFIN=ZDB-GENE-040426-1178|UniProtKB=Q7SY24	Protein kinase C beta type	ISS	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P02741	Flavin biosynthesis	P02933	Pyrimidine deaminase	STRCO|Gene=CAB92254|UniProtKB=Q9KYI4	Riboflavin biosynthesis protein RibD	ISS			PTHR44288:SF1	RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBD
P02743	Formyltetrahydroformate biosynthesis	P02957	Dihydrofolate reductase	ARATH|TAIR=AT2G21550|UniProtKB=Q9SIK4	Bifunctional dihydrofolate reductase-thymidylate synthase	ISS			PTHR11548:SF7	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE
P04374	5HT2 type receptor mediated signaling pathway	P04411	Ca2+ channel	MOUSE|MGI=MGI=103301|UniProtKB=Q8R0S4	Voltage-dependent L-type calcium channel subunit beta-4	IC			PTHR11824:SF7	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4
P05918	p38 MAPK pathway	P05919	MAPKAP-K3	BOVIN|Ensembl=ENSBTAG00000016532|UniProtKB=Q3SYZ2	MAP kinase-activated protein kinase 3	ISS	11157753	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P00021	FGF signaling pathway	P00632	Akt	MACMU|Ensembl=ENSMMUG00000001044|UniProtKB=F6SAS5	RAC-alpha serine/threonine-protein kinase	ISS	14568991	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00057	Wnt signaling pathway	P01448	CBP	CAEEL|WormBase=WBGene00009595|UniProtKB=Q7JMS5	Uncharacterized protein	ISS	10769018	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00025	Hedgehog signaling pathway	P00682	PKA	PANTR|Ensembl=ENSPTRG00000014898|UniProtKB=H2QMK2	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P05913	Enkephalin release	P05974	G-Protein (i)	MOUSE|MGI=MGI=95773|UniProtKB=Q9DC51	Guanine nucleotide-binding protein G(k) subunit alpha	IC	12488551	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00019	Endothelin signaling pathway	P00577	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	15468162	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01199	Galpha	HUMAN|HGNC=4379|UniProtKB=P29992	Guanine nucleotide-binding protein subunit alpha-11	IC	8457205	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	10644715	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	STRPU|Gene=CYIIIB|UniProtKB=P18499	Actin, cytoskeletal 3B	ISS	10974003	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P00057	Wnt signaling pathway	P01444	Wnt	RAT|RGD=1304988|UniProtKB=A0A0G2K6Q8	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF76	PROTEIN WNT-10B
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	HUMAN|HGNC=9381|UniProtKB=P22694	cAMP-dependent protein kinase catalytic subunit beta	IC	11035810	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	MOUSE|MGI=MGI=108025|UniProtKB=P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	IC	2372396	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00829	PKCzeta	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IDA	2837282	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	RAT|RGD=2248|UniProtKB=P54287	Voltage-dependent L-type calcium channel subunit beta-3	IC			PTHR11824:SF8	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-3
P00012	Cadherin signaling pathway	P00470	F-actin	ARATH|TAIR=AT2G42090|UniProtKB=P93738	Putative actin-9	IC	10974003	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P04391	Oxytocin receptor mediated signaling pathway	P04531	Oxytocin Receptor	DANRE|ZFIN=ZDB-GENE-110805-2|UniProtKB=E4W699	Isotocin receptor-like 2	ISS	11006161	PubMed	PTHR24241:SF19	OXYTOCIN RECEPTOR
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	ANOGA|EnsemblGenome=AGAP012252|UniProtKB=Q7Q042	AGAP012252-PA (Fragment)	ISS	10644715	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P04393	Ras Pathway	P04567	PI3K	TAKRU|Ensembl=ENSTRUG00000006539|UniProtKB=H2SUG3	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF94	SUBFAMILY NOT NAMED
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000009364|UniProtKB=E1BWA3	Protein kinase C	ISS	94043266	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00004	Alzheimer disease-presenilin pathway	P00157	Furin	BOVIN|Gene=PCSK1|UniProtKB=Q9GLR1	Neuroendocrine convertase 1	IDA			PTHR42884:SF14	NEUROENDOCRINE CONVERTASE 1
P00053	T cell activation	P01318	PKC-theta	RAT|RGD=620968|UniProtKB=Q9WTQ0	Protein kinase C theta type	ISS	15150272	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	DANRE|ZFIN=ZDB-GENE-020604-1|UniProtKB=Q6IQX1	Myosin, heavy polypeptide 2, fast muscle specific	ISS	10938134	PubMed	PTHR13140:SF676	MYOSIN, HEAVY POLYPEPTIDE 2, FAST MUSCLE SPECIFIC
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	8670417	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00036	Interleukin signaling pathway	P00981	SOS	RAT|RGD=1310949|UniProtKB=D4A3T0	Protein Sos1	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00059	p53 pathway	P04609	PI3K	MACMU|Ensembl=ENSMMUG00000008666|UniProtKB=F7F3S0	Uncharacterized protein	ISS	1171954	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00048	PI3 kinase pathway	P01185	SOS	MOUSE|MGI=MGI=98354|UniProtKB=Q62245	Son of sevenless homolog 1	ISS	93262494	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00047	PDGF signaling pathway	P01143	ERK	ARATH|TAIR=AT1G73670|UniProtKB=Q9C9U4	Mitogen-activated protein kinase 15	ISS	10514528	PubMed	PTHR24055:SF246	MITOGEN-ACTIVATED PROTEIN KINASE 15-RELATED
P00036	Interleukin signaling pathway	P00994	FKHRL1	PANTR|Ensembl=ENSPTRG00000018476|UniProtKB=H2R710	Forkhead box O3	ISS	12884295	PubMed	PTHR11829:SF97	FORKHEAD BOX PROTEIN O3
P02770	Pyridoxal phosphate salvage pathway	P03122	Pyridoxamine kinase	TRYB2|Gene=Tb927.6.2740|UniProtKB=D6XI07	Pyridoxal kinase	ISS	9274862	PubMed	PTHR10534:SF2	PYRIDOXAL KINASE
P00057	Wnt signaling pathway	P01458	Protein Kinase C	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	ISS	4262086	gi	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	DANRE|ZFIN=ZDB-GENE-070112-342|UniProtKB=A1L271	Uncharacterized protein	ISS			PTHR19850:SF36	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5
P00047	PDGF signaling pathway	P01143	ERK	HUMAN|HGNC=6871|UniProtKB=P28482	Mitogen-activated protein kinase 1	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00018	EGF receptor signaling pathway	P00547	PP2A	PANTR|Ensembl=ENSPTRG00000018180|UniProtKB=H2QT14	Protein phosphatase 2, regulatory subunit B', delta	ISS	96161994	PubMed	PTHR10257:SF47	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	BOVIN|Ensembl=ENSBTAG00000000215|UniProtKB=P62871	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	ISS	10391901	PubMed	PTHR19850:SF29	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P00019	Endothelin signaling pathway	P00566	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	IGI	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00007	Axon guidance mediated by semaphorins	P00340	Rac	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS	12874273	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00005	Angiogenesis	P00238	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	15474158	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	P01446	Calcineurin	DAPPU|EnsemblGenome=DAPPUDRAFT_306765|UniProtKB=E9GYL6	Putative uncharacterized protein	ISS	12015605	PubMed	PTHR23056:SF4	PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	STRPU|EnsemblGenome=SPU_006797|UniProtKB=W4XTP5	Uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00007	Axon guidance mediated by semaphorins	P00335	Fyn	HUMAN|HGNC=4037|UniProtKB=P06241	Tyrosine-protein kinase Fyn	ISS	8455940	PubMed	PTHR24418:SF44	TYROSINE-PROTEIN KINASE FYN
P00055	Transcription regulation by bZIP transcription factor	P01388	RNA Polymerase II	ORNAN|Ensembl=ENSOANG00000010454|UniProtKB=F6SGR6	Uncharacterized protein	ISS	606023	OMIM	PTHR10917:SF0	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3
P00011	Blood coagulation	P00433	uPAR	MOUSE|MGI=MGI=97611|UniProtKB=P06869	Urokinase-type plasminogen activator	IC			PTHR24264:SF38	UROKINASE-TYPE PLASMINOGEN ACTIVATOR
P00057	Wnt signaling pathway	G01559	NFAT Target Genes	MOUSE|MGI=MGI=97255|UniProtKB=Q02566	Myosin-6	IEP	89264452	PubMed	PTHR13140:SF721	MYOSIN-6
P00021	FGF signaling pathway	P00633	Ras	XENTR|Xenbase=XB-GENE-494548|UniProtKB=F7EC26	Uncharacterized protein	ISS	10825661	PubMed	PTHR24070:SF186	GTPASE KRAS
P00057	Wnt signaling pathway	P01444	Wnt	HUMAN|HGNC=12779|UniProtKB=O14905	Protein Wnt-9b	IDA	8717036	PubMed	PTHR12027:SF84	PROTEIN WNT-9B
P05730	Endogenous cannabinoid signaling	P05748	mGluR	MOUSE|MGI=MGI=1351342|UniProtKB=Q3UVX5	Metabotropic glutamate receptor 5	ISS	7476890	PubMed	PTHR24060:SF30	METABOTROPIC GLUTAMATE RECEPTOR 5
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	176892	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02784	Tyrosine biosynthesis	P03212	Chorismate mutase	SCHPO|PomBase=SPAC16E8.04c|UniProtKB=O13739	Probable chorismate mutase	ISS			PTHR21145:SF0	CHORISMATE MUTASE
P00023	General transcription regulation	P00658	TBP-associated factors	DROME|FlyBase=FBgn0022724|UniProtKB=Q9VWY6	Transcription initiation factor TFIID subunit 8	ISS	604903	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00056	VEGF signaling pathway	P01408	Akt/PKB	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	IDA	12089061	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00894	AKT	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12089061	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05926	MEK	MONDO|Ensembl=ENSMODG00000000809|UniProtKB=F6S9S9	Uncharacterized protein	ISS	18959214	gi	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00052	TGF-beta signaling pathway	P01284	JNK	MACMU|Ensembl=ENSMMUG00000008342|UniProtKB=F7HRW7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05734	Synaptic vesicle trafficking	P05772	Syntaxin 1/2	RAT|RGD=3784|UniProtKB=P61265	Syntaxin-1B	ISS	12624525	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P00060	Ubiquitin proteasome pathway	P01491	E2	MOUSE|MGI=MGI=1925141|UniProtKB=Q921J4	Ubiquitin-conjugating enzyme E2 S	ISS			PTHR44066:SF1	UBIQUITIN-CONJUGATING ENZYME E2 S
P00049	Parkinson disease	P01212	p38 MAPK	MONDO|Ensembl=ENSMODG00000013704|UniProtKB=F6YAB9	Mitogen-activated protein kinase	ISS	15761973	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	MACMU|Ensembl=ENSMMUG00000004313|UniProtKB=F6ZKL2	Phosphoinositide phospholipase C	ISS	12860966	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	MACMU|Ensembl=ENSMMUG00000018559|UniProtKB=F6YMH2	Uncharacterized protein	ISS	88248054	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P00056	VEGF signaling pathway	P01423	p38MAPK	CANLF|Ensembl=ENSCAFG00000001378|UniProtKB=O02812	Mitogen-activated protein kinase 14	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00016	Cytoskeletal regulation by Rho GTPase	P00514	MLCK	HUMAN|HGNC=29826|UniProtKB=Q32MK0	Myosin light chain kinase 3	TAS	11157482	PubMed	PTHR45411:SF1	MYOSIN LIGHT CHAIN KINASE 3
P00012	Cadherin signaling pathway	P00474	Wnt	CHICK|Ensembl=ENSGALG00000005123|UniProtKB=Q9DEB8	Protein Wnt	IDA	11266476	PubMed	PTHR12027:SF78	PROTEIN WNT-7A
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	ORNAN|Ensembl=ENSOANG00000008422|UniProtKB=F6VUT7	Synaptosomal-associated protein	ISS	10327594	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	BOVIN|Gene=AKT1|UniProtKB=Q01314	RAC-alpha serine/threonine-protein kinase	TAS	15533996	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00053	T cell activation	P01336	Jnk	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	9133421	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00005	Angiogenesis	P00203	Erk	PANTR|Ensembl=ENSPTRG00000014120|UniProtKB=H2QLB4	Mitogen-activated protein kinase	ISS	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000019142|UniProtKB=F7ECA6	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF57	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11
P00034	Integrin signalling pathway	P00947	Laminin	BOVIN|Ensembl=ENSBTAG00000008817|UniProtKB=F1MYX9	Uncharacterized protein	ISS	2538453	PubMed	PTHR44537:SF1	LAMININ SUBUNIT ALPHA-4
P00018	EGF receptor signaling pathway	P00539	14-3-3	CHICK|Gene_ORFName=RCJMB04_1e8|UniProtKB=Q5ZMT0	14-3-3 protein epsilon	ISS	10407019	PubMed	PTHR18860:SF17	14-3-3 PROTEIN EPSILON
P00017	DNA replication	P00527	Histones	MOUSE|MGI=MGI=2448319|UniProtKB=P84228	Histone H3.2	IDA	12413958	PubMed	PTHR11426:SF161	HISTONE H3.2-RELATED
P05912	Dopamine receptor mediated signaling pathway	P05946	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	188830	OMIM	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00054	Toll receptor signaling pathway	P01369	MKK1	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00131	HAC1	MACMU|Ensembl=ENSMMUG00000004934|UniProtKB=F7CDB8	Uncharacterized protein	ISS			PTHR44028:SF2	TRIPARTITE MOTIF-CONTAINING PROTEIN 2
P00017	DNA replication	P00528	Primase	RAT|RGD=631433|UniProtKB=O89044	DNA primase large subunit	ISS	8026492	PubMed	PTHR10537:SF3	DNA PRIMASE LARGE SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	22050614	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	MOUSE|MGI=MGI=95772|UniProtKB=P08752	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	12088413	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	IDA	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00010	B cell activation	P00388	PLC gamma2	PANTR|Ensembl=ENSPTRG00000008395|UniProtKB=H2QBL0	Phosphoinositide phospholipase C	ISS	2557343	PubMed	PTHR10336:SF25	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DROME|EnsemblGenome=FBgn0003660|UniProtKB=P18489	Synaptobrevin	IC	93386758	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	MACMU|Ensembl=ENSMMUG00000023188|UniProtKB=F7EIT4	Aldehyde dehydrogenase	ISS			PTHR43570:SF2	ALDEHYDE DEHYDROGENASE FAMILY 3 MEMBER B1
P00010	B cell activation	P00386	Calcineurin	MACMU|Ensembl=ENSMMUG00000015714|UniProtKB=F6SFE0	Serine/threonine-protein phosphatase	ISS	7532676	PubMed	PTHR11668:SF261	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	IC	14744463	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P05731	GABA-B receptor II signaling	P05752	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	10553940	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00052	TGF-beta signaling pathway	P01276	Co-Smads	BOVIN|Gene=SMAD4|UniProtKB=Q1HE26	Mothers against decapentaplegic homolog 4	ISS	9395284	PubMed	PTHR13703:SF45	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4
P00009	Axon guidance mediated by netrin	P00363	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00047	PDGF signaling pathway	P01168	PI3K	HUMAN|HGNC=8978|UniProtKB=P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	1171954	gi	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00029	Huntington disease	G01535	PIG3	PANTR|Ensembl=ENSPTRG00000000865|UniProtKB=H2PZ89	Crystallin, zeta (Quinone reductase)	ISS	12932731	PubMed	PTHR44154:SF1	QUINONE OXIDOREDUCTASE
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	IC	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00048	PI3 kinase pathway	P01192	p110	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00166	AICD	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	2881207	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	CHICK|Gene=GNAI1|UniProtKB=P50146	Guanine nucleotide-binding protein G(i) subunit alpha-1	ISS	15860573	PubMed	PTHR10218:SF227	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-1
P00018	EGF receptor signaling pathway	P00544	c-Cbl	HUMAN|HGNC=15961|UniProtKB=Q9ULV8	E3 ubiquitin-protein ligase CBL-C	IGI	99289203	PubMed	PTHR23007:SF12	E3 UBIQUITIN-PROTEIN LIGASE CBL-C
P00021	FGF signaling pathway	P00640	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00882	Insulin IGF	PANTR|Ensembl=ENSPTRG00000010386|UniProtKB=H2QF61	Tyrosine-protein kinase receptor	ISS	249616	gi	PTHR24416:SF402	INSULIN RECEPTOR
P00021	FGF signaling pathway	P00634	MEKK1-5	MOUSE|MGI=MGI=1346873|UniProtKB=Q61083	Mitogen-activated protein kinase kinase kinase 2	ISS	11730323	PubMed	PTHR24361:SF342	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MONDO|Ensembl=ENSMODG00000004147|UniProtKB=F6RA79	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00049	Parkinson disease	P01242	Casein kinase I	CAEEL|WormBase=WBGene00004960|UniProtKB=Q95PZ9	Serine/threonine-protein kinase spe-6	IDA	11437445	PubMed	PTHR11909:SF72	SERINE/THREONINE-PROTEIN KINASE SPE-6
P04393	Ras Pathway	P04556	Raf	CANLF|Ensembl=ENSCAFG00000015115|UniProtKB=E2RL20	Uncharacterized protein	ISS	12411479	PubMed	PTHR44000:SF4	SERINE/THREONINE-PROTEIN KINASE A-RAF
P00047	PDGF signaling pathway	P01162	MEK	HUMAN|HGNC=6840|UniProtKB=Q02750	Dual specificity mitogen-activated protein kinase kinase 1	ISS	93178455	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P02738	De novo purine biosynthesis	P02907	dADP kinase	ARATH|TAIR=AT5G63310|UniProtKB=O64903	Nucleoside diphosphate kinase II, chloroplastic	ISS			PTHR11349:SF44	NUCLEOSIDE DIPHOSPHATE KINASE II, CHLOROPLASTIC
P00036	Interleukin signaling pathway	P00965	ERK	RAT|RGD=70500|UniProtKB=P63086	Mitogen-activated protein kinase 1	IC	1169551	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00770	N-CoR	MACMU|Ensembl=ENSMMUG00000023107|UniProtKB=F7GMR8	Uncharacterized protein	ISS	10441327	PubMed	PTHR13992:SF21	NUCLEAR RECEPTOR COREPRESSOR 2
P00018	EGF receptor signaling pathway	P00557	PI3K	PANTR|Ensembl=ENSPTRG00000015642|UniProtKB=H2QNS1	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00895	INSR IGF-R IRR	MONDO|Ensembl=ENSMODG00000007100|UniProtKB=F6SWY2	Uncharacterized protein	ISS	13642251	gi	PTHR15071:SF17	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
P00004	Alzheimer disease-presenilin pathway	P00132	Dsh	CANLF|Ensembl=ENSCAFG00000019275|UniProtKB=E2QY91	Uncharacterized protein	ISS	11212302	PubMed	PTHR10878:SF5	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED
P00047	PDGF signaling pathway	P01142	p90RSK	MONDO|Ensembl=ENSMODG00000008086|UniProtKB=F6YJ34	Ribosomal protein S6 kinase	ISS	10480933	PubMed	PTHR24351:SF58	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3
P00059	p53 pathway	P04623	CBP	PANTR|Ensembl=ENSPTRG00000014418|UniProtKB=H2QLS0	Uncharacterized protein	ISS	10823891	PubMed	PTHR13808:SF4	HISTONE ACETYLTRANSFERASE P300
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	MOUSE|MGI=MGI=1927498|UniProtKB=Q99PG4	Regulator of G-protein signaling 18	IDA	11563974	PubMed	PTHR10845:SF155	REGULATOR OF G-PROTEIN SIGNALING 18
P00057	Wnt signaling pathway	P01457	GBeta	HUMAN|HGNC=20731|UniProtKB=Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	IDA	9754712	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00012	Cadherin signaling pathway	P00470	F-actin	XENTR|Xenbase=XB-GENE-6469705|UniProtKB=Q6P8G3	Actin, alpha sarcomeric/skeletal	ISS	14684598	PubMed	PTHR11937:SF240	SUBFAMILY NOT NAMED
P04392	P53 pathway feedback loops 1	P04539	p53	DANRE|ZFIN=ZDB-GENE-030814-2|UniProtKB=B0S576	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF21	TUMOR PROTEIN P73
P00036	Interleukin signaling pathway	P00965	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P06664	Gonadotropin-releasing hormone receptor pathway	P06794	MAP2K1/2	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	RCA	11730323	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00034	Integrin signalling pathway	P00951	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04398	p53 pathway feedback loops 2	P04657	P110alpha	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	15192701	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00048	PI3 kinase pathway	P01188	Gbetagamma	DROME|FlyBase=FBgn0001105|UniProtKB=P26308	Guanine nucleotide-binding protein subunit beta-1	IC	10391901	PubMed	PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04397	p53 pathway by glucose deprivation	P04641	Akt	DANRE|Ensembl=ENSDARG00000087205|UniProtKB=E7EXT6	Uncharacterized protein	ISS	7488143	PubMed	PTHR24356:SF310	SUBFAMILY NOT NAMED
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	MOUSE|MGI=MGI=1276107|UniProtKB=Q9WTR0	Matrix metalloproteinase-16	TAS	12834808	PubMed	PTHR10201:SF26	MATRIX METALLOPROTEINASE-16
P04393	Ras Pathway	P04545	Sec5	BOVIN|Ensembl=ENSBTAG00000020215|UniProtKB=E1BDW9	Uncharacterized protein	ISS			PTHR13043:SF1	EXOCYST COMPLEX COMPONENT 2
P05917	Opioid proopiomelanocortin pathway	P06012	G-protein	MACMU|Ensembl=ENSMMUG00000020116|UniProtKB=F7GK45	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1	ISS	12488551	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P05731	GABA-B receptor II signaling	P05760	AC	MONDO|Ensembl=ENSMODG00000001430|UniProtKB=F7BCI5	Uncharacterized protein	ISS	12890691	PubMed	PTHR11920:SF320	ADENYLATE CYCLASE TYPE 8
P00040	Metabotropic glutamate receptor group II pathway	G01540	BDNF	CHICK|Ensembl=ENSGALG00000012163|UniProtKB=P25429	Brain-derived neurotrophic factor	ISS	12117585	PubMed	PTHR11589:SF3	BRAIN-DERIVED NEUROTROPHIC FACTOR
P00021	FGF signaling pathway	P00627	ERK1-2	MONDO|Ensembl=ENSMODG00000015670|UniProtKB=F7EI48	Mitogen-activated protein kinase (Fragment)	ISS	1533654	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	MOUSE|MGI=MGI=1930705|UniProtKB=P61264	Syntaxin-1B	ISS	97410052	PubMed	PTHR19957:SF76	SYNTAXIN-1B
P00049	Parkinson disease	P01219	SAPK	MACMU|Ensembl=ENSMMUG00000004060|UniProtKB=F6ZKB3	Mitogen-activated protein kinase	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00648	PKC	DROME|FlyBase=FBgn0004784|UniProtKB=P13677	Protein kinase C, eye isozyme	ISS	3045562	PubMed	PTHR24356:SF236	PROTEIN KINASE C, BRAIN ISOZYME-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00867	Myosin	HUMAN|HGNC=23212|UniProtKB=Q7Z406	Myosin-14	ISS	89264452	PubMed	PTHR13140:SF462	MYOSIN-14
P00005	Angiogenesis	P00236	PI3K	MOUSE|MGI=MGI=1098211|UniProtKB=O35904	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	ISS	12707323	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00047	PDGF signaling pathway	P01154	Ras	CANLF|Ensembl=ENSCAFG00000032060|UniProtKB=J9JHN1	Uncharacterized protein	ISS			PTHR24073:SF335	RAS-RELATED PROTEIN RAB-11B
P00053	T cell activation	P01337	B7	RAT|RGD=628714|UniProtKB=O35531	Cd86 antigen, isoform CRA_c	IDA	7694363	PubMed	PTHR25466:SF2	T-LYMPHOCYTE ACTIVATION ANTIGEN CD86
P04393	Ras Pathway	P04572	JNK	RAT|RGD=3663|UniProtKB=P49187	Mitogen-activated protein kinase 10	TAS	10851062	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00049	Parkinson disease	P01236	Casein kinase II	ORYSJ|EnsemblGenome=OS03G0763000|UniProtKB=Q8W5G9	Casein kinase II, alpha chain, putative, expressed	IDA	10806215	PubMed	PTHR24054:SF33	CASEIN KINASE II SUBUNIT ALPHA, CHLOROPLASTIC
P00006	Apoptosis signaling pathway	P00273	p53	MACMU|Ensembl=ENSMMUG00000008639|UniProtKB=P56424	Cellular tumor antigen p53	ISS	11389839	PubMed	PTHR11447:SF6	CELLULAR TUMOR ANTIGEN P53
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	XENTR|Xenbase=XB-GENE-482702|UniProtKB=F6T0T9	Uncharacterized protein (Fragment)	ISS	15313841	PubMed	PTHR24353:SF37	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04583	PKC	HUMAN|HGNC=9404|UniProtKB=P41743	Protein kinase C iota type	ISS	822697	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00054	Toll receptor signaling pathway	P01345	IKKalpha	HUMAN|HGNC=1974|UniProtKB=O15111	Inhibitor of nuclear factor kappa-B kinase subunit alpha	ISS	12813046	PubMed	PTHR22969:SF13	INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
P06664	Gonadotropin-releasing hormone receptor pathway	P06738	PLA2	MOUSE|MGI=MGI=1195256|UniProtKB=P47713	Cytosolic phospholipase A2	RCA	98223459	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00034	Integrin signalling pathway	P00947	Laminin	PANTR|Ensembl=ENSPTRG00000018514|UniProtKB=H2QTK9	Uncharacterized protein	ISS	2538453	PubMed	PTHR44537:SF1	LAMININ SUBUNIT ALPHA-4
P02751	Lysine biosynthesis	P03011	N-succinyldiaminopimelate  aminotransferase	SCHPO|PomBase=SPCC777.09c|UniProtKB=O74548	Probable acetylornithine aminotransferase, mitochondrial	IDA			PTHR11986:SF79	ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MONDO|Ensembl=ENSMODG00000016311|UniProtKB=F7A632	Protein kinase C (Fragment)	ISS	10395542	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P05913	Enkephalin release	P05977	G-Protein (s)	CANLF|Ensembl=ENSCAFG00000019322|UniProtKB=E2R9G5	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=1351343|UniProtKB=Q5NCH9	Metabotropic glutamate receptor 6	ISS	12488551	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P00036	Interleukin signaling pathway	P00976	GSK3	TAKRU|Ensembl=ENSTRUG00000002302|UniProtKB=H2RYS5	Uncharacterized protein	ISS	12615961	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00004	Alzheimer disease-presenilin pathway	P00151	APPbeta	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	TAS	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P04376	5HT4 type receptor mediated signaling pathway	P04426	K+ channel	BOVIN|Ensembl=ENSBTAG00000047488|UniProtKB=G3N1D1	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	MONDO|Ensembl=ENSMODG00000004697|UniProtKB=F6TQN3	Phosphoinositide phospholipase C	ISS	11642544	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00037	Ionotropic glutamate receptor pathway	P01026	KA	MOUSE|MGI=MGI=95814|UniProtKB=Q60934	Glutamate receptor ionotropic, kainate 1	ISS	11319238	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00005	Angiogenesis	P00234	Grb2	CAEBR|Gene=CBG16856|UniProtKB=A8XPY6	Protein CBR-SEM-5	ISS			PTHR24418:SF284	PROTEIN ENHANCER OF SEVENLESS 2B
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	HUMAN|HGNC=1392|UniProtKB=Q15878	Voltage-dependent R-type calcium channel subunit alpha-1E	ISS	14624853	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P05912	Dopamine receptor mediated signaling pathway	P05957	K+ channel	DANRE|ZFIN=ZDB-GENE-040724-171|UniProtKB=Q5TZ59	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00047	PDGF signaling pathway	P01173	STAT	CANLF|Ensembl=ENSCAFG00000015346|UniProtKB=E2RE22	Signal transducer and activator of transcription	ISS	8584036	PubMed	PTHR11801:SF47	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A
P00021	FGF signaling pathway	P00648	PKC	HUMAN|HGNC=9393|UniProtKB=P17252	Protein kinase C alpha type	ISS	86289425	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P02768	Proline biosynthesis	P03113	Pyrroline-5-carboxylate reductase	PANTR|Ensembl=ENSPTRG00000009777|UniProtKB=H2R2L7	Pyrroline-5-carboxylate reductase	ISS			PTHR11645:SF6	PYRROLINE-5-CARBOXYLATE REDUCTASE 1, MITOCHONDRIAL
P00052	TGF-beta signaling pathway	P01291	Ras-GDP	DICDI|dictyBase=DDB_G0292996|UniProtKB=P03967	Ras-like protein rasD	ISS	85024887	PubMed	PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	ARATH|TAIR=AT3G18780|UniProtKB=Q96292	Actin-2	IC	14684598	PubMed	PTHR11937:SF266	ACTIN FAMILY PROTEIN-RELATED
P05726	2-arachidonoylglycerol biosynthesis	P05738	PLC	CANLF|Ensembl=ENSCAFG00000014542|UniProtKB=J9JHK9	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01087	CAT	PANTR|Ensembl=ENSPTRG00000002489|UniProtKB=H2RAF8	Uncharacterized protein	ISS	97225904	PubMed	PTHR22589:SF14	CHOLINE O-ACETYLTRANSFERASE
P00048	PI3 kinase pathway	P01179	PKB	MONDO|Ensembl=ENSMODG00000013693|UniProtKB=F6QP11	Uncharacterized protein	ISS	2745889	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04582	SNARE Complex	CAEEL|WormBase=WBGene00004897|UniProtKB=O02495	Synaptobrevin-1	ISS	8011337	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00052	TGF-beta signaling pathway	P01275	P38	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	TAS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	BOVIN|Gene=VAMP2|UniProtKB=P63026	Vesicle-associated membrane protein 2	ISS	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00046	Oxidative stress response	P01121	MKK3/6	HUMAN|HGNC=6843|UniProtKB=P46734	Dual specificity mitogen-activated protein kinase kinase 3	ISS	8900184	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00039	Metabotropic glutamate receptor group III pathway	P01041	Ca2+	BOVIN|Ensembl=ENSBTAG00000007882|UniProtKB=G3X7Z2	Uncharacterized protein	ISS	11976940	PubMed	PTHR10037:SF161	VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B
P04376	5HT4 type receptor mediated signaling pathway	P04430	G-protein	CHICK|Ensembl=ENSGALG00000007509|UniProtKB=F1NM72	Uncharacterized protein	ISS	2106672	PubMed	PTHR10218:SF212	GUANINE NUCLEOTIDE-BINDING PROTEIN G S  SUBUNIT ALPHA ISOFORMS XLAS
P04393	Ras Pathway	P04542	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	EMENI|EnsemblGenome=CADANIAG00005408|UniProtKB=O59922	cAMP-dependent protein kinase regulatory subunit	ISS	188830	OMIM	PTHR11635:SF151	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT
P00049	Parkinson disease	P01208	Hsp70	HUMAN|HGNC=5234|UniProtKB=P34931	Heat shock 70 kDa protein 1-like	IDA	12150907	PubMed	PTHR19375:SF210	HEAT SHOCK 70 KDA PROTEIN 1-LIKE
P00012	Cadherin signaling pathway	P00471	Cadherin	HUMAN|HGNC=8683|UniProtKB=Q9Y5F1	Protocadherin beta-12	IDA	8120095	PubMed	PTHR24028:SF228	PROTOCADHERIN BETA-12
P00021	FGF signaling pathway	P00644	p38	HUMAN|HGNC=6875|UniProtKB=O15264	Mitogen-activated protein kinase 13	IGI	11274345	PubMed	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00006	Apoptosis signaling pathway	P00318	PKCs	RAT|RGD=61925|UniProtKB=P09216	Protein kinase C epsilon type	ISS	2611232	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P05915	Opioid proenkephalin pathway	P05990	K+ channel	BOVIN|Ensembl=ENSBTAG00000047488|UniProtKB=G3N1D1	Uncharacterized protein	ISS	15282272	PubMed	PTHR11003:SF75	POTASSIUM CHANNEL SUBFAMILY K MEMBER 9
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00700	PKA-r	MOUSE|MGI=MGI=104878|UniProtKB=Q9DBC7	cAMP-dependent protein kinase type I-alpha regulatory subunit	IDA	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00030	Hypoxia response via HIF activation	P00823	PI3K	MACMU|Ensembl=ENSMMUG00000006224|UniProtKB=F7HLC7	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00019	Endothelin signaling pathway	P00583	cPLA2	PANTR|Ensembl=ENSPTRG00000001787|UniProtKB=H2Q0T0	Phospholipase A2	ISS	12414998	PubMed	PTHR10728:SF13	CYTOSOLIC PHOSPHOLIPASE A2
P00052	TGF-beta signaling pathway	P01283	TGFbetareceptors	RAT|RGD=69651|UniProtKB=P38438	TGF-beta receptor type-2	TAS	9759503	PubMed	PTHR23255:SF55	TGF-BETA RECEPTOR TYPE-2
P00029	Huntington disease	P00778	NMDA receptor	CANLF|Ensembl=ENSCAFG00000002617|UniProtKB=E2QUL1	Uncharacterized protein	ISS	11319238	PubMed	PTHR44285:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A
P00018	EGF receptor signaling pathway	P00553	MEKK1-5	MACMU|Ensembl=ENSMMUG00000006143|UniProtKB=F6PR50	Uncharacterized protein	ISS	9305639	PubMed	PTHR24361:SF637	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4
P00018	EGF receptor signaling pathway	P00552	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00704	RGS	BOVIN|Ensembl=ENSBTAG00000026481|UniProtKB=G3MX08	Uncharacterized protein	ISS	8756726	PubMed	PTHR10845:SF147	REGULATOR OF G-PROTEIN SIGNALING 8
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	CAEEL|WormBase=WBGene00003774|UniProtKB=G5EGQ9	NMDA class glutamate Receptor	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00029	Huntington disease	P00775	Rac	TAKRU|Ensembl=ENSTRUG00000016201|UniProtKB=H2UWV1	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF257	RAS-RELATED PROTEIN CED-10-RELATED
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	PANTR|Ensembl=ENSPTRG00000013811|UniProtKB=Q5IS80	Amyloid beta A4 protein	ISS	4502167	gi	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00046	Oxidative stress response	P01129	JNK1/2	HUMAN|HGNC=6886|UniProtKB=P45984	Mitogen-activated protein kinase 9	TAS	8394233	gi	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00047	PDGF signaling pathway	P01168	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00010	B cell activation	P00391	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00114	actin	HUMAN|HGNC=129|UniProtKB=P68133	Actin, alpha skeletal muscle	IDA	11889139	PubMed	PTHR11937:SF193	ACTIN, ALPHA SKELETAL MUSCLE
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MONDO|Ensembl=ENSMODG00000012087|UniProtKB=F7G4Q0	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	TAKRU|Ensembl=ENSTRUG00000005663|UniProtKB=H2SMS4	Uncharacterized protein	ISS	1319556	PubMed	PTHR24353:SF49	SUBFAMILY NOT NAMED
P00022	General transcription by RNA polymerase I	P00653	SL1 complex	DROME|FlyBase=FBgn0002842|UniProtKB=Q9VP40	Spermatocyte arrest	ISS	604905	OMIM	PTHR12321:SF102	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
P00057	Wnt signaling pathway	P01438	PP2A	DANRE|ZFIN=ZDB-GENE-030904-6|UniProtKB=Q7ZUQ2	Ppp2r5e1 protein	ISS	8703017	PubMed	PTHR10257:SF5	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM
P00046	Oxidative stress response	P01129	JNK1/2	DANRE|ZFIN=ZDB-GENE-010202-1|UniProtKB=Q9DGD9	Mitogen-activated protein kinase 8	TAS	7600581	PubMed	PTHR24055:SF334	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00041	Metabotropic glutamate receptor group I pathway	P01053	PLC	RAT|RGD=3345|UniProtKB=Q9QW07	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	ISS	12176394	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00005	Angiogenesis	P00219	PKC	CANLF|Gene=PRKCD|UniProtKB=Q5PU49	Protein kinase C delta type	ISS	2837282	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000006551|UniProtKB=F6Y4G8	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TRIVA|Gene=TVAG_054030|UniProtKB=A2G1K5	Actin	IC	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00039	Metabotropic glutamate receptor group III pathway	P01044	mGluR4/6/7/8	PANTR|Ensembl=ENSPTRG00000017612|UniProtKB=C7G3N0	Glutamate receptor, metabotropic 6	ISS	11431030	PubMed	PTHR24060:SF24	METABOTROPIC GLUTAMATE RECEPTOR 6
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	MACMU|Ensembl=ENSMMUG00000003457|UniProtKB=F7EBR0	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00057	Wnt signaling pathway	P01444	Wnt	MONDO|Ensembl=ENSMODG00000012401|UniProtKB=F6PMQ6	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF33	PROTEIN WNT-5A
P00015	Circadian clock system	G01504	bmal1	TAKRU|Ensembl=ENSTRUG00000008391|UniProtKB=H2T8M1	Uncharacterized protein	ISS			PTHR23042:SF52	ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 1
P04395	Vasopressin synthesis	P04593	Glycopeptide	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	IC	6717565	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	TAKRU|Ensembl=ENSTRUG00000010596|UniProtKB=H2TPZ3	Uncharacterized protein	ISS	89107990	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00082	L-type calcium channels	BOVIN|Ensembl=ENSBTAG00000010026|UniProtKB=F1MTK5	Uncharacterized protein	ISS	91056091	PubMed	PTHR10037:SF139	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
P00005	Angiogenesis	P00219	PKC	DANRE|ZFIN=ZDB-GENE-011105-1|UniProtKB=Q90XF2	Protein kinase C iota type	ISS	3045562	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	CHICK|Gene=CHRM3|UniProtKB=P49578	Muscarinic acetylcholine receptor M3	IDA			PTHR43914:SF5	MUSCARINIC ACETYLCHOLINE RECEPTOR M3
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	RAT|RGD=621888|UniProtKB=Q64617	Protein kinase C eta type	TAS	10395542	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00053	T cell activation	P01307	SOS	CANLF|Ensembl=ENSCAFG00000006340|UniProtKB=F1Q118	Uncharacterized protein	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	CHICK|Ensembl=ENSGALG00000014071|UniProtKB=F1P1X4	Uncharacterized protein	ISS	9065779	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00008	Axon guidance mediated by Slit/Robo	P00355	Rho	CANLF|Ensembl=ENSCAFG00000015764|UniProtKB=F1PYF1	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF17	RHO-RELATED GTP-BINDING PROTEIN RHOJ
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000015615|UniProtKB=H2QNQ4	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF214	PROTEIN KINASE C IOTA TYPE
P06664	Gonadotropin-releasing hormone receptor pathway	P06827	GSK3	MOUSE|MGI=MGI=1861437|UniProtKB=Q9WV60	Glycogen synthase kinase-3 beta	RCA	21361340	gi	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00003	Alzheimer disease-amyloid secretase pathway	P00105	Furin	PANTR|Ensembl=ENSPTRG00000007461|UniProtKB=H2QA34	Furin (Paired basic amino acid cleaving enzyme)	ISS	11861638	PubMed	PTHR42884:SF1	FURIN
P00057	Wnt signaling pathway	P01426	IP3 Gated Calcium Channel	PANTR|Ensembl=ENSPTRG00000018054|UniProtKB=H2QSU0	Uncharacterized protein	ISS	11463389	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00056	VEGF signaling pathway	P01425	PKC	MOUSE|MGI=MGI=97599|UniProtKB=P16054	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00834	Cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P05734	Synaptic vesicle trafficking	P05778	SNAP-25	PANTR|Ensembl=ENSPTRG00000013246|UniProtKB=Q5R1X1	Synaptosomal-associated protein 25	RCA			PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00006	Apoptosis signaling pathway	P00318	PKCs	MACMU|Ensembl=ENSMMUG00000007972|UniProtKB=F7HNV1	Protein kinase C	ISS	12359310	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9401|UniProtKB=Q02156	Protein kinase C epsilon type	ISS	3755548	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00012	Cadherin signaling pathway	P00470	F-actin	BRAFL|Gene=BRAFLDRAFT_114535|UniProtKB=C3ZHN2	Putative uncharacterized protein	ISS	11889126	PubMed	PTHR11937:SF356	SUBFAMILY NOT NAMED
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MOUSE|MGI=MGI=103013|UniProtKB=Q01815	Voltage-dependent L-type calcium channel subunit alpha-1C	IC	8838325	PubMed	PTHR10037:SF188	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C
P00006	Apoptosis signaling pathway	P00274	JNK	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MACMU|Ensembl=ENSMMUG00000014271|UniProtKB=F7BYH7	Protein kinase C	ISS	2611232	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04395	Vasopressin synthesis	P04594	Neurophysin	MOUSE|MGI=MGI=88121|UniProtKB=P35455	Vasopressin-neurophysin 2-copeptin	ISS	9756087	PubMed	PTHR11681:SF9	VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN
P00007	Axon guidance mediated by semaphorins	P00340	Rac	TAKRU|Ensembl=ENSTRUG00000004543|UniProtKB=H2SEG4	Uncharacterized protein	ISS	14564011	PubMed	PTHR24072:SF248	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CANAL|CGD=CAL0000176774|UniProtKB=Q5A1D3	Extracellular signal-regulated kinase 1	IDA	11707292	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	RAT|RGD=619747|UniProtKB=O70257	Syntaxin-7	IC	10321247	PubMed	PTHR19957:SF90	SYNTAXIN-7
P00036	Interleukin signaling pathway	P00979	MAPKAPK2	PANTR|Ensembl=ENSPTRG00000001915|UniProtKB=H2Q104	Mitogen-activated protein kinase-activated protein kinase 2	ISS	8262198	PubMed	PTHR24349:SF63	MAP KINASE-ACTIVATED PROTEIN KINASE 2
P04393	Ras Pathway	P04570	AKT	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	10485710	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MOUSE|MGI=MGI=98331|UniProtKB=P60879	Synaptosomal-associated protein 25	ISS	94043281	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00021	FGF signaling pathway	P00647	SHP2	TAKRU|Ensembl=ENSTRUG00000018529|UniProtKB=H2VDZ2	Tyrosine-protein phosphatase non-receptor type	ISS	14525967	PubMed	PTHR19134:SF299	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
P04398	p53 pathway feedback loops 2	P04661	PI3K	BOVIN|Ensembl=ENSBTAG00000026290|UniProtKB=F1MTL5	Phosphatidylinositol 3-kinase	ISS	14742297	PubMed	PTHR10048:SF7	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
P00006	Apoptosis signaling pathway	P00310	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00551	Akt	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	IGI	12719720	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00046	Oxidative stress response	P01131	MKP5	RAT|RGD=1310090|UniProtKB=Q5FVI9	Dual specificity protein phosphatase 26	ISS			PTHR10159:SF112	DUAL SPECIFICITY PROTEIN PHOSPHATASE 26
P00049	Parkinson disease	P01242	Casein kinase I	MONDO|Ensembl=ENSMODG00000025188|UniProtKB=F7C1G3	Uncharacterized protein	ISS	10617630	PubMed	PTHR11909:SF20	CASEIN KINASE I ISOFORM ALPHA
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	DROME|FlyBase=FBgn0001105|UniProtKB=P26308	Guanine nucleotide-binding protein subunit beta-1	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P04374	5HT2 type receptor mediated signaling pathway	P04415	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	10414292	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P00037	Ionotropic glutamate receptor pathway	P01010	NR1	RAT|RGD=2736|UniProtKB=P35439	Glutamate receptor ionotropic, NMDA 1	ISS	11554549	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00019	Endothelin signaling pathway	P00566	ERK	DANRE|ZFIN=ZDB-GENE-040121-1|UniProtKB=Q7ZVK8	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00048	PI3 kinase pathway	P01192	p110	BOVIN|Ensembl=ENSBTAG00000006909|UniProtKB=F1MYM3	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00053	T cell activation	P01332	Akt	CANLF|Ensembl=ENSCAFG00000015806|UniProtKB=F1Q4F8	Uncharacterized protein	ISS	11135576	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00720	GsPCR	MOUSE|MGI=MGI=109323|UniProtKB=Q02152	5-hydroxytryptamine receptor 2B	IDA			PTHR24247:SF31	5-HYDROXYTRYPTAMINE RECEPTOR 2B
P00015	Circadian clock system	G01497	cry	BOVIN|Ensembl=ENSBTAG00000021223|UniProtKB=F1N0J9	Uncharacterized protein	ISS	14507900	PubMed	PTHR11455:SF15	CRYPTOCHROME-2
P00006	Apoptosis signaling pathway	P00299	Caspase 8	MACMU|Ensembl=ENSMMUG00000031296|UniProtKB=F7C587	Uncharacterized protein	ISS	11788820	PubMed	PTHR10454:SF162	CASPASE-8
P00029	Huntington disease	P00790	beta-Tubulin	RAT|RGD=1588452|UniProtKB=P85108	Tubulin beta-2A chain	TAS	9454836	PubMed	PTHR11588:SF100	TUBULIN BETA-2A CHAIN
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	MOUSE|MGI=MGI=97613|UniProtKB=Q9Z1B3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	ISS	12176394	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00037	Ionotropic glutamate receptor pathway	P01000	KA5	MOUSE|MGI=MGI=95818|UniProtKB=Q61626	Glutamate receptor ionotropic, kainate 5	ISS	12080343	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00005	Angiogenesis	P00254	GTPase	PANTR|Ensembl=ENSPTRG00000014922|UniProtKB=H2QML4	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF153	TRANSFORMING PROTEIN RHOA
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00724	GIRK	ORNAN|Ensembl=ENSOANG00000006415|UniProtKB=F6WIC7	Uncharacterized protein	ISS	2433589	PubMed	PTHR11767:SF19	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2
P00047	PDGF signaling pathway	P01171	PLCgamma	CANLF|Ensembl=ENSCAFG00000009082|UniProtKB=F1PS03	Phosphoinositide phospholipase C	ISS	10934033	PubMed	PTHR10336:SF52	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	CANLF|Ensembl=ENSCAFG00000012108|UniProtKB=E2RRD1	Uncharacterized protein	ISS	10693759	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000023202|UniProtKB=F7EU36	Uncharacterized protein	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P04372	5-Hydroxytryptamine degredation	P04402	Aldehyde Dehydrogenase	ORYSJ|EnsemblGenome=OS02G0730000|UniProtKB=Q9LRI6	Mitochondrial aldehyde dehydrogenase ALDH2a	IC			PTHR11699:SF211	ALDEHYDE DEHYDROGENASE 5, MITOCHONDRIAL
P00005	Angiogenesis	P00219	PKC	CHICK|Ensembl=ENSGALG00000006014|UniProtKB=F1N9L1	Protein kinase C	ISS	87115883	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	PANTR|Ensembl=ENSPTRG00000021043|UniProtKB=H2R6M4	Uncharacterized protein	ISS	14765990	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P02772	Pyruvate metabolism	P03140	Pyruvate Carboxylase	MOUSE|MGI=MGI=97520|UniProtKB=Q05920	Pyruvate carboxylase, mitochondrial	ISS	8048912	PubMed	PTHR43778:SF2	PYRUVATE CARBOXYLASE, MITOCHONDRIAL
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00716	Phosphorylase b kinase	TAKRU|Ensembl=ENSTRUG00000008685|UniProtKB=H2TXN3	Uncharacterized protein	ISS			PTHR23050:SF326	CALMODULIN
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P04498	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	TAKRU|Ensembl=ENSTRUG00000006206|UniProtKB=H2SRS1	Uncharacterized protein	ISS	14744463	PubMed	PTHR24353:SF109	PROTEIN KINASE, CAMP-DEPENDENT, CATALYTIC, BETA
P00025	Hedgehog signaling pathway	P00692	GSK3	RAT|RGD=70982|UniProtKB=P18266	Glycogen synthase kinase-3 beta	ISS	7529201	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00005	Angiogenesis	P00236	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	HUMAN|HGNC=9056|UniProtKB=Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	ISS	10934033	PubMed	PTHR10336:SF11	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3
P04373	5HT1 type receptor mediated signaling pathway	P04404	5HT1 Receptor	HUMAN|HGNC=5292|UniProtKB=P30939	5-hydroxytryptamine receptor 1F	ISS	1608964	PubMed	PTHR24247:SF34	5-HYDROXYTRYPTAMINE RECEPTOR 1F
P00018	EGF receptor signaling pathway	P00543	ERK1-2	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	9393975	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00021	FGF signaling pathway	P00644	p38	DANRE|ZFIN=ZDB-GENE-010202-2|UniProtKB=Q9DGE2	Mitogen-activated protein kinase 14A	IGI	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02734	Chorismate biosynthesis	P02872	3-Dehydroquinate synthase	LEPIN|EnsemblGenome=LB_086|UniProtKB=Q8EXX1	3-dehydroquinate synthase	ISS			PTHR43622:SF1	3-DEHYDROQUINATE SYNTHASE
P00053	T cell activation	P01322	PI3K	PANTR|Ensembl=ENSPTRG00000000120|UniProtKB=H2PXY8	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF35	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
P00016	Cytoskeletal regulation by Rho GTPase	P00515	Cdc42	MOUSE|MGI=MGI=106211|UniProtKB=P60766	Cell division control protein 42 homolog	ISS	12932731	PubMed	PTHR24072:SF136	CELL DIVISION CONTROL PROTEIN 42 HOMOLOG
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	IC	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00005	Angiogenesis	P00243	Raf	MACMU|Ensembl=ENSMMUG00000007450|UniProtKB=F6SWC0	RAF proto-oncogene serine/threonine-protein kinase	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	MOUSE|MGI=MGI=95822|UniProtKB=Q01098	Glutamate receptor ionotropic, NMDA 2C	ISS	http://harvester.embl.de/harvester/Q149/Q14957.htm	Website	PTHR43958:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	ORYSJ|EnsemblGenome=OS02G0148100|UniProtKB=Q6Z437	Mitogen-activated protein kinase 3	ISS	6491800	gi	PTHR24055:SF216	SUBFAMILY NOT NAMED
P04391	Oxytocin receptor mediated signaling pathway	P04532	SNARE Complex	PANTR|Ensembl=ENSPTRG00000006975|UniProtKB=H2Q995	Synaptosomal-associated protein	ISS	94043281	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00001	Adrenaline and noradrenaline biosynthesis	P00072	SNARE	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	ISS	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IDA	15611108	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P04385	Histamine H1 receptor mediated signaling pathway	P04488	G-Protein	MONDO|Ensembl=ENSMODG00000012932|UniProtKB=F7G1U7	Uncharacterized protein (Fragment)	ISS	1905731	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00029	Huntington disease	P00778	NMDA receptor	XENTR|Xenbase=XB-GENE-494200|UniProtKB=F7CS79	Uncharacterized protein	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MONDO|Ensembl=ENSMODG00000013810|UniProtKB=F6SXE3	Protein Wnt	ISS	8717036	PubMed	PTHR12027:SF88	PROTEIN WNT-3A
P00034	Integrin signalling pathway	P00948	Rho	PANTR|Ensembl=ENSPTRG00000001112|UniProtKB=H2PZP2	Ras homolog gene family, member C	ISS	11973360	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00048	PI3 kinase pathway	P01190	PDK1 ACT	CHICK|Ensembl=ENSGALG00000006418|UniProtKB=Q5F3U4	Uncharacterized protein	ISS	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01086	nAChR	MACMU|Ensembl=ENSMMUG00000023736|UniProtKB=F7G778	Uncharacterized protein	ISS	12098588	PubMed	PTHR18945:SF445	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3
P00012	Cadherin signaling pathway	P00470	F-actin	HUMAN|HGNC=130|UniProtKB=P62736	Actin, aortic smooth muscle	IC	14684598	PubMed	PTHR11937:SF201	ACTIN, AORTIC SMOOTH MUSCLE
P00005	Angiogenesis	P00219	PKC	HUMAN|HGNC=9403|UniProtKB=P24723	Protein kinase C eta type	ISS	2611232	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000014043|UniProtKB=F7ANI8	Synaptosomal-associated protein	ISS	9070898	PubMed	PTHR19305:SF4	SYNAPTOSOMAL-ASSOCIATED PROTEIN 23
P00019	Endothelin signaling pathway	P00577	PI3K	MONDO|Ensembl=ENSMODG00000021305|UniProtKB=F7G3I5	Uncharacterized protein	ISS	12969321	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05916	Opioid prodynorphin pathway	G06048	prepropressophysin	MOUSE|MGI=MGI=97453|UniProtKB=P35454	Oxytocin-neurophysin 1	ISS	3768139	PubMed	PTHR11681:SF2	OXYTOCIN-NEUROPHYSIN 1
P00041	Metabotropic glutamate receptor group I pathway	P01054	GluR5	MOUSE|MGI=MGI=95814|UniProtKB=Q60934	Glutamate receptor ionotropic, kainate 1	ISS	12871085	PubMed	PTHR18966:SF36	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1
P00019	Endothelin signaling pathway	P00568	PKC	RAT|RGD=3397|UniProtKB=P63319	Protein kinase C gamma type	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P06959	CCKR signaling map	P07127	Adenylate cyclase	HUMAN|HGNC=232|UniProtKB=Q08828	Adenylate cyclase type 1	RCA	9083028	PubMed	PTHR11920:SF299	ADENYLATE CYCLASE TYPE 1
P00021	FGF signaling pathway	P00633	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	8409414	PubMed	PTHR24070:SF385	GTPASE HRAS
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	MOUSE|MGI=MGI=97595|UniProtKB=P20444	Protein kinase C alpha type	TAS	3045562	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P04393	Ras Pathway	P04548	ATF2	CANLF|Ensembl=ENSCAFG00000013332|UniProtKB=F1PCQ4	Uncharacterized protein	ISS	9819389	PubMed	PTHR19304:SF9	CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2
P00006	Apoptosis signaling pathway	P00319	TRADD	PANTR|Ensembl=ENSPTRG00000008215|UniProtKB=H2R3V5	Uncharacterized protein	ISS	10892748	PubMed	PTHR14913:SF0	TUMOR NECROSIS FACTOR RECEPTOR TYPE 1-ASSOCIATED DEATH DOMAIN PROTEIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00721	Ggamma	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P04393	Ras Pathway	P04557	MEK	MOUSE|MGI=MGI=1346866|UniProtKB=P31938	Dual specificity mitogen-activated protein kinase kinase 1	IDA	92362878	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P04391	Oxytocin receptor mediated signaling pathway	P04533	PKC	MOUSE|MGI=MGI=97597|UniProtKB=P63318	Protein kinase C gamma type	ISS	2837282	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00861	PKC	MOUSE|MGI=MGI=97596|UniProtKB=P68404	Protein kinase C beta type	IDA	3755548	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P04380	Cortocotropin releasing factor receptor signaling pathway	P04457	SNARE Complex	MONDO|Ensembl=ENSMODG00000015607|UniProtKB=F6Z5I2	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF103	VESICLE-ASSOCIATED MEMBRANE PROTEIN 8
P00019	Endothelin signaling pathway	P00570	PKA	HUMAN|HGNC=9380|UniProtKB=P17612	cAMP-dependent protein kinase catalytic subunit alpha	ISS	10553940	PubMed	PTHR24353:SF82	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA
P00021	FGF signaling pathway	P00640	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IGI	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00021	FGF signaling pathway	P00635	FRS2	BOVIN|Ensembl=ENSBTAG00000009861|UniProtKB=A6H792	FRS3 protein	ISS			PTHR21258:SF39	FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 3
P00029	Huntington disease	P00788	Calpain	HUMAN|HGNC=1478|UniProtKB=Q9UMQ6	Calpain-11	IDA	11675509	PubMed	PTHR10183:SF322	CALPAIN-11
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00874	PLCbetagamma	BOVIN|Ensembl=ENSBTAG00000008338|UniProtKB=P10894	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	TAS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00730	GqPCR	MACMU|Ensembl=ENSMMUG00000014227|UniProtKB=P56490	Muscarinic acetylcholine receptor M5	IDA	10069496	PubMed	PTHR43914:SF3	MUSCARINIC ACETYLCHOLINE RECEPTOR M5
P00029	Huntington disease	P00810	GAPDH	RAT|RGD=620150|UniProtKB=Q9ESV6	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific	IPI			PTHR10836:SF79	GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE, TESTIS-SPECIFIC
P00048	PI3 kinase pathway	P01192	p110	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	129387	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00018	EGF receptor signaling pathway	P00562	p38	HUMAN|HGNC=6874|UniProtKB=P53778	Mitogen-activated protein kinase 12	IGI	4506785	gi	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P00006	Apoptosis signaling pathway	P00318	PKCs	BOVIN|Ensembl=ENSBTAG00000020614|UniProtKB=F1MDC9	Protein kinase C epsilon type	ISS	12810623	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MACMU|Ensembl=ENSMMUG00000012574|UniProtKB=F7HG18	Uncharacterized protein	ISS	1849282	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00052	TGF-beta signaling pathway	P01286	TGFbeta	MACMU|Ensembl=ENSMMUG00000015826|UniProtKB=F7CEL9	Metalloendopeptidase	ISS	9759503	PubMed	PTHR43978:SF1	TOLLOID-LIKE PROTEIN 2
P00013	Cell cycle	P00480	Proteasome	HUMAN|HGNC=9557|UniProtKB=O00232	26S proteasome non-ATPase regulatory subunit 12	ISS	12477932	PubMed	PTHR10855:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12
P00025	Hedgehog signaling pathway	P00682	PKA	RAT|RGD=3394|UniProtKB=P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P05916	Opioid prodynorphin pathway	P06002	G-protein	HUMAN|HGNC=19664|UniProtKB=Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	IC			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00012	Cadherin signaling pathway	P00470	F-actin	MONDO|Ensembl=ENSMODG00000010521|UniProtKB=F7DQK7	Uncharacterized protein	ISS	14684598	PubMed	PTHR11937:SF227	ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE
P04386	Histamine H2 receptor mediated signaling pathway	P04491	PKA	RAT|RGD=1310574|UniProtKB=P68182	cAMP-dependent protein kinase catalytic subunit beta	ISS	89107990	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00049	Parkinson disease	P01208	Hsp70	TRYB2|Gene=Tb11.01.3110|UniProtKB=Q383E5	Heat shock protein 70	IDA	12150907	PubMed	PTHR19375:SF250	HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED
P00036	Interleukin signaling pathway	P00989	Ets	PANTR|Ensembl=ENSPTRG00000011340|UniProtKB=H2QGX8	Uncharacterized protein	ISS	8970723	PubMed	PTHR11849:SF174	TRANSCRIPTION FACTOR SPI-B
P04374	5HT2 type receptor mediated signaling pathway	P04416	G-protein	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1650351	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00034	Integrin signalling pathway	P00925	MEK	RAT|RGD=1306620|UniProtKB=B1H230	Map2k3 protein	ISS	11730323	PubMed	PTHR24361:SF191	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
P00019	Endothelin signaling pathway	P00577	PI3K	MOUSE|MGI=MGI=1098772|UniProtKB=O08908	Phosphatidylinositol 3-kinase regulatory subunit beta	ISS	12701063	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	PANTR|Ensembl=ENSPTRG00000018890|UniProtKB=Q5R1X3	Actin, cytoplasmic 1	ISS	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00057	Wnt signaling pathway	P01458	Protein Kinase C	RAT|RGD=67383|UniProtKB=P09215	Protein kinase C delta type	IDA	11032873	PubMed	PTHR24356:SF177	PROTEIN KINASE C DELTA TYPE
P00029	Huntington disease	P00796	Kainate receptor	PANTR|Ensembl=ENSPTRG00000011042|UniProtKB=H2QGF5	Uncharacterized protein	ISS	1717158	PubMed	PTHR18966:SF351	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00868	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00047	PDGF signaling pathway	P01154	Ras	MACMU|Ensembl=ENSMMUG00000021659|UniProtKB=F7F5K9	GTPase HRas isoform 1	ISS	15369798	PubMed	PTHR24070:SF385	GTPASE HRAS
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00889	ERK	SCLS1|Gene=SS1G_11866|UniProtKB=A7F3M0	Mitogen-activated protein kinase	ISS	176948	OMIM	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	CANLF|Ensembl=ENSCAFG00000005856|UniProtKB=F1PL90	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF12	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	92354059	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00017	DNA replication	P00527	Histones	ORNAN|Ensembl=ENSOANG00000000225|UniProtKB=F7CMG6	Histone H3	ISS	20448842	PubMed	PTHR11426:SF167	HISTONE H3.1
P00019	Endothelin signaling pathway	P00570	PKA	PANTR|Ensembl=ENSPTRG00000021003|UniProtKB=H2QXB9	Uncharacterized protein	ISS	11035810	PubMed	PTHR24353:SF113	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	12040174	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04375	5HT3 type receptor mediated signaling pathway	P04423	SNARE Complex	RAT|RGD=620225|UniProtKB=Q9Z2P6	Synaptosomal-associated protein 29	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00046	Oxidative stress response	P01132	c-jun	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	14555214	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	HUMAN|HGNC=12642|UniProtKB=P23763	Vesicle-associated membrane protein 1	ISS	93386758	PubMed	PTHR21136:SF107	VESICLE-ASSOCIATED MEMBRANE PROTEIN 1
P00029	Huntington disease	P00780	Microtubule	PHANO|Gene=SNOG_06790|UniProtKB=P41799	Tubulin beta chain	IDA	9454836	PubMed	PTHR11588:SF9	TUBULIN BETA-1 CHAIN-RELATED
P00009	Axon guidance mediated by netrin	P00363	PI3K	ORNAN|Ensembl=ENSOANG00000014698|UniProtKB=F7GAP5	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01079	SNARE Complex	DROME|FlyBase=FBgn0013342|UniProtKB=M9PE71	Neuronal synaptobrevin, isoform J	ISS	14997396	PubMed	PTHR21136:SF168	NEURONAL SYNAPTOBREVIN, ISOFORM J-RELATED
P00044	Nicotinic acetylcholine receptor signaling pathway	P01095	beta	DANRE|ZFIN=ZDB-GENE-090312-169|UniProtKB=E7F8A2	Uncharacterized protein	ISS	22213672	PubMed	PTHR18945:SF80	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	G04676	p110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00049	Parkinson disease	P01211	ERK	MACMU|Ensembl=ENSMMUG00000012524|UniProtKB=F7ECR3	Mitogen-activated protein kinase	ISS	12787066	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	MOUSE|MGI=MGI=894282|UniProtKB=O08858	Somatostatin receptor type 5	IDA	12181435	PubMed	PTHR24229:SF20	SOMATOSTATIN RECEPTOR TYPE 5
P00020	FAS signaling pathway	P00615	JNK	CAEBR|Gene=CBG05733|UniProtKB=A8X1S0	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF225	STRESS-ACTIVATED PROTEIN KINASE JNK
P00018	EGF receptor signaling pathway	P00554	Shc	MACMU|Ensembl=ENSMMUG00000006581|UniProtKB=F7HPS2	SHC-transforming protein 1 isoform 3	ISS	95096035	PubMed	PTHR10337:SF2	SHC-TRANSFORMING PROTEIN 1
P00006	Apoptosis signaling pathway	P00269	MAPK	ARATH|TAIR=AT1G07880|UniProtKB=Q9LQQ9	Mitogen-activated protein kinase 13	ISS	12787066	PubMed	PTHR24055:SF185	MITOGEN-ACTIVATED PROTEIN KINASE 13
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	MONDO|Ensembl=ENSMODG00000005770|UniProtKB=F6XYX9	Uncharacterized protein (Fragment)	ISS	10414292	PubMed	PTHR21136:SF78	VESICLE-ASSOCIATED MEMBRANE PROTEIN 3
P04398	p53 pathway feedback loops 2	P04661	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	12707323	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00057	Wnt signaling pathway	P01448	CBP	MOUSE|MGI=MGI=1098280|UniProtKB=P45481	CREB-binding protein	IDA	10769018	PubMed	PTHR13808:SF5	CREB-BINDING PROTEIN
P00057	Wnt signaling pathway	P01451	Galpha	CHICK|Ensembl=ENSGALG00000015177|UniProtKB=Q5F3B5	Uncharacterized protein	ISS	1333286	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00873	Galphai/q	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	RCA			PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	TAS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	ARATH|TAIR=AT1G67220|UniProtKB=Q9FYH1	Histone acetyltransferase HAC2	TAS	10664585	PubMed	PTHR13808:SF6	HISTONE ACETYLTRANSFERASE HAC2
P00005	Angiogenesis	P00230	PDGFR	MACMU|Ensembl=ENSMMUG00000011557|UniProtKB=F7BTH1	Platelet-derived growth factor receptor beta	ISS	12374780	PubMed	PTHR24416:SF53	PLATELET-DERIVED GROWTH FACTOR RECEPTOR BETA
P00006	Apoptosis signaling pathway	P00307	ELF2alpha	HALSA|EnsemblGenome=VNG_0549G|UniProtKB=Q9HRT8	Translation initiation factor 2 subunit alpha	ISS			PTHR10602:SF0	EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	MOUSE|MGI=MGI=96624|UniProtKB=P70227	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12880387	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00005	Angiogenesis	P00200	Dsh	MACMU|Ensembl=ENSMMUG00000006553|UniProtKB=F7HRY3	Uncharacterized protein	ISS	10409711	PubMed	PTHR10878:SF6	SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
P00029	Huntington disease	P00780	Microtubule	HUMAN|HGNC=20772|UniProtKB=Q13509	Tubulin beta-3 chain	IDA	12932731	PubMed	PTHR11588:SF43	TUBULIN BETA-3 CHAIN
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	MACMU|Ensembl=ENSMMUG00000017758|UniProtKB=F7EZA7	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P04373	5HT1 type receptor mediated signaling pathway	P04405	SNARE Complex	MOUSE|MGI=MGI=1914724|UniProtKB=Q9ERB0	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00030	Hypoxia response via HIF activation	P00823	PI3K	RAT|RGD=620917|UniProtKB=Q9Z1L0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	TAS	7937853	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P05912	Dopamine receptor mediated signaling pathway	P05956	SNARE Complex	DANRE|ZFIN=ZDB-GENE-980526-392|UniProtKB=Q6PC54	Synaptosomal-associated protein 25-B	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00048	PI3 kinase pathway	P01179	PKB	CANLF|Ensembl=ENSCAFG00000005388|UniProtKB=F1PRG4	Uncharacterized protein	ISS	12089343	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00020	FAS signaling pathway	P00622	FADD	HUMAN|HGNC=3573|UniProtKB=Q13158	FAS-associated death domain protein	IGI	7536190	PubMed	PTHR15077:SF8	FAS-ASSOCIATED DEATH DOMAIN PROTEIN
P00030	Hypoxia response via HIF activation	P00819	AKT	RAT|RGD=2082|UniProtKB=P47197	RAC-beta serine/threonine-protein kinase	TAS	12062094	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00880	beta-arrestin	RAT|RGD=2157|UniProtKB=P29067	Beta-arrestin-2	ISS	9388255	PubMed	PTHR11792:SF20	BETA-ARRESTIN-2
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00744	Phospholipase C-beta	HUMAN|HGNC=9055|UniProtKB=Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	IDA	7822322	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P00043	Muscarinic acetylcholine receptor 2 and 4 signaling pathway	P01075	PKA	DROME|FlyBase=FBgn0022382|UniProtKB=P81900	cAMP-dependent protein kinase type II regulatory subunit	IC	88234494	PubMed	PTHR44021:SF5	CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IDA	11313908	PubMed	PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P00005	Angiogenesis	P00254	GTPase	DANRE|ZFIN=ZDB-GENE-040718-144|UniProtKB=Q6DHE8	Rho-related GTP-binding protein RhoA-D	ISS	10556059	PubMed	PTHR24072:SF100	RHO-RELATED GTP-BINDING PROTEIN RHOC
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00842	IP3R	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	ISS	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	HUMAN|HGNC=391|UniProtKB=P31749	RAC-alpha serine/threonine-protein kinase	TAS	9395488	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00029	Huntington disease	P00778	NMDA receptor	MONDO|Ensembl=ENSMODG00000018204|UniProtKB=F6PGX6	Uncharacterized protein	ISS	11554554	PubMed	PTHR43958:SF2	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
P00006	Apoptosis signaling pathway	P00274	JNK	BOVIN|Ensembl=ENSBTAG00000020048|UniProtKB=A4FV00	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04379	Beta3 adrenergic receptor signaling pathway	P04447	SNARE Complex	DROME|FlyBase=FBgn0034913|UniProtKB=Q9W1I8	LD03592p	IC	9070898	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00018	EGF receptor signaling pathway	P00565	PKC	PANTR|Ensembl=ENSPTRG00000006418|UniProtKB=H2Q8F2	Protein kinase C eta type	ISS	11554554	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00053	T cell activation	P01322	PI3K	RAT|RGD=620916|UniProtKB=A0A0G2K344	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05932	IP3R	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	RCA	11007872	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01070	K+ channel	PANTR|Ensembl=ENSPTRG00000013736|UniProtKB=H2QKS4	Uncharacterized protein	ISS	12165472	PubMed	PTHR11537:SF6	POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 2
P05918	p38 MAPK pathway	P06031	p38alpha	DANRE|ZFIN=ZDB-GENE-021007-1|UniProtKB=Q9DGE1	Mitogen-activated protein kinase 14B	ISS	10851062	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P00006	Apoptosis signaling pathway	P00269	MAPK	MONDO|Ensembl=ENSMODG00000017722|UniProtKB=F7FHD1	Mitogen-activated protein kinase	ISS	17127730	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00029	Huntington disease	P00786	ARF	CANAL|CGD=CAL0003401|UniProtKB=Q5AND9	ADP-ribosylation factor 1	ISS	12932731	PubMed	PTHR11711:SF30	ADP-RIBOSYLATION FACTOR 2
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	CHICK|Ensembl=ENSGALG00000004792|UniProtKB=E1BR11	Phosphoinositide phospholipase C	ISS	12176394	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P02771	Pyrimidine Metabolism	P03125	Dihydropyrimidinase	MACMU|Ensembl=ENSMMUG00000012718|UniProtKB=F7DF35	Uncharacterized protein	ISS	Q90635	SPACC	PTHR11647:SF56	DIHYDROPYRIMIDINASE-RELATED PROTEIN 2
P00021	FGF signaling pathway	P00640	PI3K	MOUSE|MGI=MGI=1353576|UniProtKB=Q9JHG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	ISS	9094719	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00737	Rap1GAP	RAT|RGD=1309908|UniProtKB=F1LV89	Protein Rap1gap	ISS	10419452	PubMed	PTHR15711:SF3	RAP1 GTPASE-ACTIVATING PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00735	IP3 channel	BOVIN|Gene=ITPR2|UniProtKB=Q8WN96	Inositol 1,4,5-trisphosphate receptor type 2	IDA	21588212	PubMed	PTHR13715:SF53	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2
P00039	Metabotropic glutamate receptor group III pathway	P01035	PKA	PANTR|Ensembl=ENSPTRG00000000899|UniProtKB=H2R1G3	Protein kinase, cAMP-dependent, catalytic, beta	ISS	10553940	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00034	Integrin signalling pathway	P00951	Jnk	HUMAN|HGNC=6872|UniProtKB=P53779	Mitogen-activated protein kinase 10	IDA	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P05730	Endogenous cannabinoid signaling	P05744	Ggamma	CANLF|Ensembl=ENSCAFG00000001230|UniProtKB=E2RGI5	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF5	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-5
P00002	Alpha adrenergic receptor signaling pathway	P00075	PKC	PANTR|Ensembl=ENSPTRG00000009557|UniProtKB=H2QDQ1	Protein kinase C	ISS	3755548	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00019	Endothelin signaling pathway	P00591	PLCbeta	CAEEL|WormBase=WBGene00001177|UniProtKB=G5EBH0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8	IGI	12860966	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01091	SNARE Complex	HUMAN|HGNC=11133|UniProtKB=O95721	Synaptosomal-associated protein 29	IC	10414292	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00057	Wnt signaling pathway	P01446	Calcineurin	PANTR|Ensembl=ENSPTRG00000020059|UniProtKB=H2QVV0	Serine/threonine-protein phosphatase	ISS	12015605	PubMed	PTHR11668:SF186	SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT GAMMA ISOFORM
P00059	p53 pathway	P01486	Akt	MACMU|Ensembl=ENSMMUG00000003621|UniProtKB=F6QE96	RAC-beta serine/threonine-protein kinase	ISS	12799317	PubMed	PTHR24356:SF176	RAC-BETA SERINE/THREONINE-PROTEIN KINASE
P05915	Opioid proenkephalin pathway	P05995	proenkephalin	DANRE|ZFIN=ZDB-GENE-030729-31|UniProtKB=A8E7S2	Uncharacterized protein	ISS	9622029	PubMed	PTHR11438:SF3	PROENKEPHALIN-A
P00057	Wnt signaling pathway	P01440	Cadherin	CHICK|Gene=CDH7|UniProtKB=Q90763	Cadherin-7	IDA	8120095	PubMed	PTHR24027:SF91	CADHERIN-7
P00008	Axon guidance mediated by Slit/Robo	P00352	DCC	MONDO|Ensembl=ENSMODG00000011028|UniProtKB=F7F4D5	Uncharacterized protein	ISS	8861902	PubMed	PTHR44146:SF3	NETRIN RECEPTOR DCC
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	DANRE|ZFIN=ZDB-GENE-050417-238|UniProtKB=F1QEC8	Uncharacterized protein	ISS	91072385	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00004	Alzheimer disease-presenilin pathway	P00130	Matrix metalloprotease	HUMAN|HGNC=7159|UniProtKB=P45452	Collagenase 3	TAS	12834808	PubMed	PTHR10201:SF165	COLLAGENASE 3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MOUSE|MGI=MGI=1922019|UniProtKB=Q8BTI9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	ISS	11756681	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00903	PDK1/2	PANTR|Ensembl=ENSPTRG00000007655|UniProtKB=H2R0W1	Uncharacterized protein	ISS	97250749	PubMed	PTHR24356:SF163	3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED
P04376	5HT4 type receptor mediated signaling pathway	P04428	SNARE Complex	MOUSE|MGI=MGI=103077|UniProtKB=Q64704	Syntaxin-3	ISS	7690687	PubMed	PTHR19957:SF34	SYNTAXIN-3
P00007	Axon guidance mediated by semaphorins	P00340	Rac	CHICK|Ensembl=ENSGALG00000002859|UniProtKB=F6UBD2	Uncharacterized protein	ISS	12932731	PubMed	PTHR24072:SF182	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3
P04393	Ras Pathway	P04570	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	11322783	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	RAT|RGD=621004|UniProtKB=O89040	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	ISS	1846707	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P05731	GABA-B receptor II signaling	P05752	PKA	HUMAN|HGNC=9392|UniProtKB=P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	RCA	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P04378	Beta2 adrenergic receptor signaling pathway	P04443	G-Protein	DICDI|dictyBase=DDB_G0277143|UniProtKB=P36408	Guanine nucleotide-binding protein subunit beta	IC			PTHR19850:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
P00007	Axon guidance mediated by semaphorins	P00340	Rac	CANLF|Gene=RAC1|UniProtKB=P62999	Ras-related C3 botulinum toxin substrate 1	ISS	15470041	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	PANTR|Ensembl=ENSPTRG00000006916|UniProtKB=H2Q961	Phosphoinositide phospholipase C	ISS	12657629	PubMed	PTHR10336:SF10	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2
P02740	De novo pyrimidine ribonucleotides biosythesis	P02923	UDP kinase	HALSA|EnsemblGenome=VNG_1160G|UniProtKB=P61136	Nucleoside diphosphate kinase	ISS			PTHR11349:SF91	NUCLEOSIDE DIPHOSPHATE KINASE
P00005	Angiogenesis	P00241	VEGF	CHICK|Gene=VEGFA|UniProtKB=P67964	Vascular endothelial growth factor A	ISS			PTHR12025:SF5	VASCULAR ENDOTHELIAL GROWTH FACTOR A
P00029	Huntington disease	P00797	p53	MACMU|Ensembl=ENSMMUG00000016466|UniProtKB=F7GBH1	Uncharacterized protein	ISS	12932731	PubMed	PTHR11447:SF8	TUMOR PROTEIN 63
P02738	De novo purine biosynthesis	P02889	dGDP kinase	EMENI|EnsemblGenome=CADANIAG00004263|UniProtKB=Q8TFN0	Nucleoside diphosphate kinase	ISS			PTHR11349:SF32	NUCLEOSIDE DIPHOSPHATE KINASE
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05930	Gbeta	MOUSE|MGI=MGI=104581|UniProtKB=P29387	Guanine nucleotide-binding protein subunit beta-4	RCA	10391901	PubMed	PTHR19850:SF28	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	TRIAD|EnsemblGenome=TriadG56111|UniProtKB=B3RX77	Non-muscle actin 6.2	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00034	Integrin signalling pathway	P00907	ERK	MOUSE|MGI=MGI=1346858|UniProtKB=P63085	Mitogen-activated protein kinase 1	ISS	10851062	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01417	Raf	CHICK|Gene=BRAF|UniProtKB=Q04982	Serine/threonine-protein kinase B-raf	ISS	12411479	PubMed	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P02775	Salvage pyrimidine ribonucleotides	P03153	Cytidylate kinase	BOVIN|Ensembl=ENSBTAG00000019956|UniProtKB=Q2KIW9	UMP-CMP kinase	ISS			PTHR23359:SF107	UMP-CMP KINASE
P00020	FAS signaling pathway	P00615	JNK	CHICK|Ensembl=ENSGALG00000013761|UniProtKB=P79996	Mitogen-activated protein kinase 9	TAS	7600581	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	ORYSJ|EnsemblGenome=OS10G0510000|UniProtKB=A3C6D7	Actin-2	ISS	11889126	PubMed	PTHR11937:SF252	SUBFAMILY NOT NAMED
P05911	Angiotensin II-stimulated signaling through G proteins and beta-arrestin	P05937	MAPK	CANLF|Ensembl=ENSCAFG00000015421|UniProtKB=E2R2N2	Mitogen-activated protein kinase	ISS	11504705	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00023	General transcription regulation	P00658	TBP-associated factors	MACMU|Ensembl=ENSMMUG00000008696|UniProtKB=F7E5W7	Uncharacterized protein	ISS			PTHR15138:SF18	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4
P00004	Alzheimer disease-presenilin pathway	P00142	Wnt	MACMU|Ensembl=ENSMMUG00000017346|UniProtKB=F7H9B8	Protein Wnt	ISS	11266476	PubMed	PTHR12027:SF72	PROTEIN WNT-6
P02750	Lipoate_biosynthesis	P03003	Lipoyl-protein ligase	DEIRA|EnsemblGenome=DR_0764|UniProtKB=Q9RWA5	Octanoyltransferase	ISS			PTHR10993:SF2	OCTANOYLTRANSFERASE
P00049	Parkinson disease	P01219	SAPK	MOUSE|MGI=MGI=1346861|UniProtKB=Q91Y86	Mitogen-activated protein kinase 8	ISS	10207617	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P02738	De novo purine biosynthesis	P02901	Adenosuccinate lyase	DEIRA|EnsemblGenome=DR_2178|UniProtKB=Q9RSE6	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P00053	T cell activation	P01311	Raf	RAT|RGD=3531|UniProtKB=P11345	RAF proto-oncogene serine/threonine-protein kinase	IDA	15211515	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	BOVIN|Ensembl=ENSBTAG00000007644|UniProtKB=P30671	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	IDA	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00018	EGF receptor signaling pathway	P00565	PKC	RAT|RGD=3399|UniProtKB=P09217	Protein kinase C zeta type	IGI	3045562	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00036	Interleukin signaling pathway	P00981	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8188688	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P00021	FGF signaling pathway	P00627	ERK1-2	DANRE|ZFIN=ZDB-GENE-030722-2|UniProtKB=Q6P023	Mitogen-activated protein kinase	ISS	11707292	PubMed	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00044	Nicotinic acetylcholine receptor signaling pathway	P01097	Myosin	DANRE|ZFIN=ZDB-GENE-030318-3|UniProtKB=E7FGA0	Uncharacterized protein	ISS	22028976	PubMed	PTHR13140:SF706	UNCONVENTIONAL MYOSIN-VI
P00011	Blood coagulation	P00416	Prothrombin	RAT|RGD=61996|UniProtKB=P18292	Prothrombin	ISS	+176930	OMIM	PTHR24254:SF10	PROTHROMBIN
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00725	GoPCR	PANTR|Ensembl=ENSPTRG00000014576|UniProtKB=H2QLZ9	Uncharacterized protein	ISS	12351712	PubMed	PTHR24060:SF98	METABOTROPIC GLUTAMATE RECEPTOR 7
P00021	FGF signaling pathway	P00646	RasGAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	4506431	gi	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	DANRE|ZFIN=ZDB-GENE-990715-10|UniProtKB=Q9YI02	Nuclear oncoprotein	IGI	10485843	PubMed	PTHR10005:SF24	NUCLEAR ONCOPROTEIN
P04391	Oxytocin receptor mediated signaling pathway	P04530	PLC beta	MOUSE|MGI=MGI=1921305|UniProtKB=Q8K4S1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	ISS	10934033	PubMed	PTHR10336:SF6	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1
P00057	Wnt signaling pathway	P01442	TGFbetaactivated Kinase-1	MOUSE|MGI=MGI=107191|UniProtKB=P36898	Bone morphogenetic protein receptor type-1B	IDA			PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P00019	Endothelin signaling pathway	P00591	PLCbeta	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	1846707	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00029	Huntington disease	P00780	Microtubule	MACMU|Ensembl=ENSMMUG00000011029|UniProtKB=F7DCY3	Uncharacterized protein	ISS	12932731	PubMed	PTHR11588:SF55	TUBULIN BETA-8 CHAIN-RELATED
P02738	De novo purine biosynthesis	P02896	Adenylate kinase	MACMU|Ensembl=ENSMMUG00000000143|UniProtKB=F7H3S6	GTP:AMP phosphotransferase AK3, mitochondrial	ISS			PTHR23359:SF68	GTP:AMP PHOSPHOTRANSFERASE AK3, MITOCHONDRIAL
P00034	Integrin signalling pathway	P00931	Integrin beta	MACMU|Ensembl=ENSMMUG00000003289|UniProtKB=F7FG54	Integrin beta	ISS	3487386	PubMed	PTHR10082:SF25	INTEGRIN BETA-3
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	MONDO|Ensembl=ENSMODG00000019685|UniProtKB=F6TD14	Uncharacterized protein	ISS	7937853	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P02744	Fructose galactose metabolism	P02959	Fructose bisphosphate aldolase	MOUSE|MGI=MGI=87994|UniProtKB=P05064	Fructose-bisphosphate aldolase A	ISS	84261525	PubMed	PTHR11627:SF1	FRUCTOSE-BISPHOSPHATE ALDOLASE A
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00836	Gbetagamma	MACMU|Ensembl=ENSMMUG00000014447|UniProtKB=F7BB02	Guanine nucleotide-binding protein subunit gamma	ISS	11313908	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P02738	De novo purine biosynthesis	P02900	AICAR transformylase	MYCTU|EnsemblGenome=Rv0957|UniProtKB=P9WHM7	Bifunctional purine biosynthesis protein PurH	ISS			PTHR11692:SF0	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	ARATH|TAIR=AT3G12980|UniProtKB=Q9LE42	Histone acetyltransferase HAC5	TAS	10823891	PubMed	PTHR13808:SF1	NEJIRE, ISOFORM C
P00020	FAS signaling pathway	P00615	JNK	RAT|RGD=628847|UniProtKB=P49186	Mitogen-activated protein kinase 9	TAS	11007936	PubMed	PTHR24055:SF172	MITOGEN-ACTIVATED PROTEIN KINASE 9
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MONDO|Ensembl=ENSMODG00000005623|UniProtKB=F7CFG8	Guanine nucleotide-binding protein subunit gamma	ISS	9754712	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00032	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade	P00892	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	9763606	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	BOVIN|Ensembl=ENSBTAG00000017762|UniProtKB=F1MYW8	Guanine nucleotide-binding protein subunit gamma	ISS			PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00053	T cell activation	P01316	MHC-antigen	HUMAN|HGNC=4938|UniProtKB=P20036	HLA class II histocompatibility antigen, DP alpha 1 chain	IPI	73139	PubMed	PTHR19944:SF64	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DP ALPHA 1 CHAIN
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	XENTR|Xenbase=XB-GENE-479467|UniProtKB=F7EH19	Mitogen-activated protein kinase (Fragment)	ISS	64894	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	MACMU|Ensembl=ENSMMUG00000022114|UniProtKB=F7H7V5	Uncharacterized protein	ISS	8717036	PubMed	PTHR11309:SF81	FRIZZLED-1
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	CHICK|Ensembl=ENSGALG00000009003|UniProtKB=P60878	Synaptosomal-associated protein 25	ISS	9070898	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	RAT|RGD=621516|UniProtKB=G3V6P8	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF9	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-12
P00003	Alzheimer disease-amyloid secretase pathway	P00109	PKC	CAEEL|WormBase=WBGene00004034|UniProtKB=Q19266	Protein kinase C-like 3	TAS	2837282	PubMed	PTHR24356:SF303	ATYPICAL PROTEIN KINASE C
P04378	Beta2 adrenergic receptor signaling pathway	P04444	PKA	ANOGA|Gene=AgaP_AGAP008039|UniProtKB=Q7Q3T7	AGAP008039-PA (Fragment)	ISS	10553940	PubMed	PTHR24353:SF114	PROTEIN KINASE DC1-RELATED
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00870	IL2	MOUSE|MGI=MGI=96543|UniProtKB=P10749	Interleukin-1 beta	TAS			PTHR44849:SF1	INTERLEUKIN-1 BETA
P00059	p53 pathway	P04609	PI3K	PANTR|Ensembl=ENSPTRG00000010694|UniProtKB=H2QFS6	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta)	ISS	129387	gi	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P00052	TGF-beta signaling pathway	P01280	Ras-GTP	DANRE|ZFIN=ZDB-GENE-050417-352|UniProtKB=Q568M0	Related RAS viral (R-ras) oncogene homolog 2	ISS			PTHR24070:SF17	RAS-RELATED PROTEIN R-RAS2
P00006	Apoptosis signaling pathway	P00310	PI3K	PANTR|Ensembl=ENSPTRG00000015452|UniProtKB=H2QNG6	Uncharacterized protein	ISS	129387	gi	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00010	B cell activation	P00391	PI3K	HUMAN|HGNC=8976|UniProtKB=P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	IDA	10799299	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00004	Alzheimer disease-presenilin pathway	P00150	LRP	PANTR|Ensembl=ENSPTRG00000010806|UniProtKB=H2QG00	Low density lipoprotein receptor-related protein 3	ISS	11907044	PubMed	PTHR44062:SF1	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 3
P00016	Cytoskeletal regulation by Rho GTPase	P00511	ARP2/3	ORNAN|Ensembl=ENSOANG00000004783|UniProtKB=F7FN72	Actin-related protein 2/3 complex subunit 3	ISS	5031597	gi	PTHR12391:SF0	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
P00005	Angiogenesis	P00236	PI3K	PANTR|Ensembl=ENSPTRG00000000685|UniProtKB=H2PYY1	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)	ISS	7937853	PubMed	PTHR10155:SF2	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000014668|UniProtKB=F7E823	Uncharacterized protein	ISS	14777622	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P04398	p53 pathway feedback loops 2	P04651	Ras	MONDO|Ensembl=ENSMODG00000025248|UniProtKB=F7F5X1	Uncharacterized protein	ISS	9869449	PubMed	PTHR24070:SF186	GTPASE KRAS
P00021	FGF signaling pathway	P00636	FGFR1-4	PANTR|Ensembl=ENSPTRG00000020176|UniProtKB=H2R210	Fibroblast growth factor receptor	ISS	9763444	PubMed	PTHR24416:SF131	FIBROBLAST GROWTH FACTOR RECEPTOR 1
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	TRIVA|Gene=TVAG_512800|UniProtKB=A2HNG1	Actin (Fragment)	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00035	Interferon-gamma signaling pathway	P00961	STAT1	DANRE|ZFIN=ZDB-GENE-980526-499|UniProtKB=Q6P943	Signal transducer and activator of transcription	TAS	10523304	PubMed	PTHR11801:SF18	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
P00005	Angiogenesis	P00203	Erk	TAKRU|Ensembl=ENSTRUG00000015300|UniProtKB=H2UQ68	Mitogen-activated protein kinase	ISS	1352389	gi	PTHR24055:SF203	MITOGEN-ACTIVATED PROTEIN KINASE 1
P00056	VEGF signaling pathway	P01413	PI3K	CANLF|Ensembl=ENSCAFG00000014978|UniProtKB=E2RH85	Uncharacterized protein	ISS	14526383	PubMed	PTHR10155:SF1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
P04398	p53 pathway feedback loops 2	P04657	P110alpha	BOVIN|Ensembl=ENSBTAG00000009232|UniProtKB=P32871	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00053	T cell activation	P01300	ERK	HUMAN|HGNC=6877|UniProtKB=P27361	Mitogen-activated protein kinase 3	IDA	10748187	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IDA	15572354	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P05918	p38 MAPK pathway	P06031	p38alpha	RAT|RGD=70496|UniProtKB=P70618	Mitogen-activated protein kinase 14	RCA	10514528	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P02762	Pentose phosphate pathway	P03071	Ribulose 5-P Isomerase	HUMAN|HGNC=10297|UniProtKB=P49247	Ribose-5-phosphate isomerase	RCA			PTHR11934:SF0	RIBOSE-5-PHOSPHATE ISOMERASE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00835	MAPK	PHANO|EnsemblGenome=SNOG_03299|UniProtKB=F5HEA9	Mitogen-activated protein kinase	ISS	10851062	PubMed	PTHR24055:SF333	MITOGEN-ACTIVATED PROTEIN KINASE FUS3
P00018	EGF receptor signaling pathway	P00565	PKC	CAEEL|WormBase=WBGene00006599|UniProtKB=P34722	Protein kinase C-like 1	IGI	22533439	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00053	T cell activation	P01322	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	12660731	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00036	Interleukin signaling pathway	P00966	mTOR	CHICK|Ensembl=ENSGALG00000003339|UniProtKB=F1NUX4	Uncharacterized protein	ISS	7518356	PubMed	PTHR11139:SF9	SERINE/THREONINE-PROTEIN KINASE MTOR
P00025	Hedgehog signaling pathway	P00687	Cubitus interruptus repressor	RAT|RGD=620272|UniProtKB=F1M9H1	Protein Gli3	ISS	10976059	PubMed	PTHR19818:SF5	TRANSCRIPTIONAL ACTIVATOR GLI3
P00036	Interleukin signaling pathway	P00996	STAT	MOUSE|MGI=MGI=103038|UniProtKB=P42227	Signal transducer and activator of transcription 3	IC	11726030	PubMed	PTHR11801:SF2	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
P00047	PDGF signaling pathway	P01154	Ras	BOVIN|Ensembl=ENSBTAG00000046797|UniProtKB=A5D7R9	NRAS protein	ISS	12393454	PubMed	PTHR24070:SF189	GTPASE NRAS
P00002	Alpha adrenergic receptor signaling pathway	P00076	IP3R	XENTR|Xenbase=XB-GENE-920765|UniProtKB=F6VHF7	Uncharacterized protein	ISS	12880387	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P04393	Ras Pathway	P04569	Cdc42	CAEBR|Gene=CBG13013|UniProtKB=A8XGW3	Protein CBR-CDC-42	ISS	4757952	gi	PTHR24072:SF192	CDC42 HOMOLOG
P00053	T cell activation	P01306	Ras	XENTR|Xenbase=XB-GENE-479381|UniProtKB=Q28EW2	Uncharacterized protein	ISS	12105419	PubMed	PTHR24070:SF385	GTPASE HRAS
P00010	B cell activation	P00385	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00029	Huntington disease	P00807	Actin	HUMAN|HGNC=132|UniProtKB=P60709	Actin, cytoplasmic 1	IDA	3487386	PubMed	PTHR11937:SF192	ACTIN, CYTOPLASMIC 1
P00056	VEGF signaling pathway	P01408	Akt/PKB	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	ISS	12226078	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P04393	Ras Pathway	P04545	Sec5	MONDO|Ensembl=ENSMODG00000008367|UniProtKB=F7CDZ8	Uncharacterized protein	ISS			PTHR13043:SF1	EXOCYST COMPLEX COMPONENT 2
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CHICK|Ensembl=ENSGALG00000010000|UniProtKB=F1NG47	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00056	VEGF signaling pathway	P01425	PKC	PANTR|Ensembl=ENSPTRG00000002270|UniProtKB=H2R0T5	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P04373	5HT1 type receptor mediated signaling pathway	P04403	PKA	MACMU|Ensembl=ENSMMUG00000015404|UniProtKB=F6Q503	Uncharacterized protein	ISS	2372396	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00036	Interleukin signaling pathway	P00995	c-Myc	MOUSE|MGI=MGI=97250|UniProtKB=P01108	Myc proto-oncogene protein	ISS	11274345	PubMed	PTHR11514:SF2	MYC PROTO-ONCOGENE PROTEIN
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00713	CREB	CAEEL|WormBase=WBGene00010545|UniProtKB=G5EBG3	CBP/p300 homolog	IDA			PTHR13808:SF1	NEJIRE, ISOFORM C
P00041	Metabotropic glutamate receptor group I pathway	P01055	PKC	PANTR|Ensembl=ENSPTRG00000007895|UniProtKB=H2QAS6	Protein kinase C	ISS	11554554	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00037	Ionotropic glutamate receptor pathway	P01013	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	14997396	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00034	Integrin signalling pathway	P00912	Arp2/3	MOUSE|MGI=MGI=1915021|UniProtKB=Q9CPW4	Actin-related protein 2/3 complex subunit 5	ISS	9230079	PubMed	PTHR12644:SF1	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5
P00057	Wnt signaling pathway	P01458	Protein Kinase C	MOUSE|MGI=MGI=97601|UniProtKB=Q02111	Protein kinase C theta type	IDA	10747026	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00016	Cytoskeletal regulation by Rho GTPase	P00523	Rac	DROME|FlyBase=FBgn0010333|UniProtKB=P40792	Ras-related protein Rac1	ISS	4757952	gi	PTHR24072:SF187	RAS-RELATED PROTEIN RAC1-RELATED
P04377	Beta1 adrenergic receptor signaling pathway	P04437	PKA	BOVIN|Gene=PRKAR2B|UniProtKB=P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	ISS	3037538	PubMed	PTHR44021:SF3	CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT
P00026	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	P00711	GiPCR	MOUSE|MGI=MGI=96274|UniProtKB=P28334	5-hydroxytryptamine receptor 1B	IDA	12441358	PubMed	PTHR24247:SF16	5-HYDROXYTRYPTAMINE RECEPTOR 1B
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01066	SNARE Complex	DROME|FlyBase=FBgn0266720|UniProtKB=Q9VH76	Synaptosomal-associated protein	IC	12475239	PubMed	PTHR19305:SF14	SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04587	Ca2+ channel	MACMU|Ensembl=ENSMMUG00000014498|UniProtKB=F7GEI8	Uncharacterized protein	ISS	11976940	PubMed	PTHR10037:SF57	VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E
P00003	Alzheimer disease-amyloid secretase pathway	P00085	APP	MOUSE|MGI=MGI=88059|UniProtKB=P12023	Amyloid beta A4 protein	IDA	9450754	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00019	Endothelin signaling pathway	P00577	PI3K	DICDI|dictyBase=DDB_G0275011|UniProtKB=P54675	Phosphatidylinositol 3-kinase 3	IGI	129387	gi	PTHR10048:SF48	PHOSPHATIDYLINOSITOL 3-KINASE 3
P00010	B cell activation	P00381	Raf	CANLF|Ensembl=ENSCAFG00000004951|UniProtKB=E2REI6	Uncharacterized protein	ISS	12865432	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00049	Parkinson disease	P01227	20S proteasome	MOUSE|MGI=MGI=104883|UniProtKB=O70435	Proteasome subunit alpha type-3	TAS	12859888	PubMed	PTHR11599:SF10	PROTEASOME SUBUNIT ALPHA TYPE-3
P00034	Integrin signalling pathway	P00936	PI3K	CHICK|Ensembl=ENSGALG00000008934|UniProtKB=O42391	Phosphoinositide 3-kinase catalytic subunit	IPI	1171954	gi	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04380	Cortocotropin releasing factor receptor signaling pathway	P04453	ACTH	DANRE|ZFIN=ZDB-GENE-041014-294|UniProtKB=Q5SPP4	Uncharacterized protein	ISS	3229286	PubMed	PTHR11416:SF7	PRO-OPIOMELANOCORTIN
P04393	Ras Pathway	P04542	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	IDA	20384795	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00030	Hypoxia response via HIF activation	P00823	PI3K	HUMAN|HGNC=8975|UniProtKB=P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	ISS	14597618	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00034	Integrin signalling pathway	P00947	Laminin	RAT|RGD=1562668|UniProtKB=F1LPI5	Laminin, beta 3, isoform CRA_a	ISS	2538453	PubMed	PTHR10574:SF268	LAMININ SUBUNIT BETA-3
P04393	Ras Pathway	P04564	MAPKAP	MACMU|Ensembl=ENSMMUG00000010495|UniProtKB=F7BFL2	MAP kinase-activated protein kinase 3	ISS	11335727	PubMed	PTHR24349:SF64	MAP KINASE-ACTIVATED PROTEIN KINASE 3
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	CHICK|Ensembl=ENSGALG00000003943|UniProtKB=Q5F3X1	Protein kinase C	ISS	88030055	PubMed	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	MONDO|Ensembl=ENSMODG00000019262|UniProtKB=F6Q8L1	Receptor protein serine/threonine kinase	ISS	10683140	PubMed	PTHR23255:SF62	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B
P02738	De novo purine biosynthesis	P02892	5-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase	RAT|RGD=1307617|UniProtKB=D3ZW08	Adenylosuccinate lyase	ISS			PTHR43172:SF1	ADENYLOSUCCINATE LYASE
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	MACMU|Ensembl=ENSMMUG00000014425|UniProtKB=F7BIC2	Protein kinase C epsilon type	ISS	88223367	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00037	Ionotropic glutamate receptor pathway	P01024	NMDA	ANOGA|EnsemblGenome=AGAP001478|UniProtKB=Q7PXM3	AGAP001478-PA	ISS	11319238	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00010	B cell activation	P00379	SOS	MONDO|Ensembl=ENSMODG00000008801|UniProtKB=F6QUW1	Uncharacterized protein (Fragment)	ISS	8041791	PubMed	PTHR23113:SF168	SON OF SEVENLESS HOMOLOG 1
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	10747026	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00053	T cell activation	P01312	MEK	RAT|RGD=61888|UniProtKB=P36506	Dual specificity mitogen-activated protein kinase kinase 2	IDA	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00018	EGF receptor signaling pathway	P00546	GAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	11847220	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	ORNAN|Ensembl=ENSOANG00000013961|UniProtKB=F6VPY1	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF25	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-2
P05913	Enkephalin release	P05974	G-Protein (i)	TAKRU|Ensembl=ENSTRUG00000012118|UniProtKB=H2U163	Uncharacterized protein	ISS			PTHR19850:SF47	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-1
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04584	G-Protein	MOUSE|MGI=MGI=95785|UniProtKB=Q61011	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	IC			PTHR19850:SF31	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G T  SUBUNIT BETA-3
P04386	Histamine H2 receptor mediated signaling pathway	P04492	AC	RAT|RGD=619966|UniProtKB=F1LQT1	Adenylate cyclase 7	ISS	15581358	PubMed	PTHR11920:SF273	ADENYLATE CYCLASE TYPE 7
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04585	TRH	BOVIN|Ensembl=ENSBTAG00000006295|UniProtKB=P01223	Thyrotropin subunit beta	ISS			PTHR11515:SF5	THYROTROPIN SUBUNIT BETA
P05916	Opioid prodynorphin pathway	P06002	G-protein	MOUSE|MGI=MGI=102703|UniProtKB=P50153	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	IC			PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00016	Cytoskeletal regulation by Rho GTPase	P00507	Rho	ORNAN|Ensembl=ENSOANG00000008835|UniProtKB=F7FR08	Uncharacterized protein	ISS	11973360	PubMed	PTHR24072:SF0	RHO-RELATED GTP-BINDING PROTEIN RHOB
P00029	Huntington disease	P00790	beta-Tubulin	ARATH|TAIR=AT5G62690|UniProtKB=Q56YW9	Tubulin beta-2 chain	TAS	9454836	PubMed	PTHR11588:SF259	TUBULIN BETA-2 CHAIN-RELATED
P00055	Transcription regulation by bZIP transcription factor	P01384	PKA	RAT|RGD=3393|UniProtKB=P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	ISS	91298951	PubMed	PTHR44021:SF1	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT
P04391	Oxytocin receptor mediated signaling pathway	P04534	G-Protein	BOVIN|Ensembl=ENSBTAG00000009789|UniProtKB=E1BA29	Uncharacterized protein	ISS	8457205	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00562	p38	PANTR|Gene=MAPK13|UniProtKB=Q9N272	Mitogen-activated protein kinase 13	ISS	13994136	gi	PTHR24055:SF107	MITOGEN-ACTIVATED PROTEIN KINASE 13
P00006	Apoptosis signaling pathway	P00260	AKT	CHICK|Ensembl=ENSGALG00000011620|UniProtKB=F1NMS0	Uncharacterized protein	ISS	12719720	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00052	TGF-beta signaling pathway	P01293	p42/p44MAPKs	BOVIN|Ensembl=ENSBTAG00000016156|UniProtKB=E1B8P9	Mitogen-activated protein kinase	ISS	20562757	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00005	Angiogenesis	P00236	PI3K	CANLF|Ensembl=ENSCAFG00000011212|UniProtKB=F1Q3M8	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	11691998	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00040	Metabotropic glutamate receptor group II pathway	P01050	PKA	TAKRU|Ensembl=ENSTRUG00000016660|UniProtKB=H2V080	Uncharacterized protein	ISS	91298951	PubMed	PTHR11635:SF129	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT
P00030	Hypoxia response via HIF activation	P00819	AKT	MACMU|Ensembl=ENSMMUG00000019995|UniProtKB=F7FNH8	RAC-gamma serine/threonine-protein kinase isoform 1	ISS	12062094	PubMed	PTHR24356:SF190	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	CAEBR|Gene=CBG01645|UniProtKB=A8WR64	Protein kinase C	ISS	15572354	PubMed	PTHR24356:SF225	PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED
P00057	Wnt signaling pathway	P01436	Transducin-like Enhance of Split 1-3	MONDO|Ensembl=ENSMODG00000009200|UniProtKB=F7CCH6	Uncharacterized protein	ISS	9783586	PubMed	PTHR10814:SF24	TRANSDUCIN-LIKE ENHANCER PROTEIN 3
P00049	Parkinson disease	P01212	p38 MAPK	MACMU|Ensembl=ENSMMUG00000008444|UniProtKB=F6V343	Mitogen-activated protein kinase	ISS	9548470	PubMed	PTHR24055:SF110	MITOGEN-ACTIVATED PROTEIN KINASE 14
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	XENTR|Xenbase=XB-GENE-486491|UniProtKB=A8KBH6	Protein kinase C beta type	ISS	86272097	PubMed	PTHR24356:SF158	PROTEIN KINASE C BETA TYPE
P00053	T cell activation	P01300	ERK	MOUSE|MGI=MGI=1346859|UniProtKB=Q63844	Mitogen-activated protein kinase 3	ISS	11707292	PubMed	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00046	Oxidative stress response	P01131	MKP5	YEAST|SGD=S000001465|UniProtKB=Q02256	Tyrosine-protein phosphatase YVH1	ISS			PTHR10159:SF402	DUAL SPECIFICITY PROTEIN PHOSPHATASE 19
P04393	Ras Pathway	P04567	PI3K	MACMU|Ensembl=ENSMMUG00000005188|UniProtKB=F7CTS2	Uncharacterized protein	ISS	9188528	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00036	Interleukin signaling pathway	P00964	p90RSK	MONDO|Ensembl=ENSMODG00000006241|UniProtKB=F7FRY0	Ribosomal protein S6 kinase	ISS	15526037	PubMed	PTHR24351:SF25	RIBOSOMAL PROTEIN S6 KINASE ALPHA-2
P00019	Endothelin signaling pathway	P00566	ERK	CANLF|Ensembl=ENSCAFG00000018974|UniProtKB=F1PXS7	Uncharacterized protein	ISS	20384797	gi	PTHR24055:SF257	MITOGEN-ACTIVATED PROTEIN KINASE 3
P00003	Alzheimer disease-amyloid secretase pathway	P00086	p3	CHICK|Ensembl=ENSGALG00000015770|UniProtKB=E1C440	Uncharacterized protein	IDA	14598312	PubMed	PTHR23103:SF7	AMYLOID BETA A4 PROTEIN
P00021	FGF signaling pathway	P00646	RasGAP	HUMAN|HGNC=9871|UniProtKB=P20936	Ras GTPase-activating protein 1	IGI	9764820	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P04380	Cortocotropin releasing factor receptor signaling pathway	P04458	G-Protein	MOUSE|MGI=MGI=1336169|UniProtKB=Q9CXP8	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	IC	2122451	PubMed	PTHR13809:SF6	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-10
P00050	Plasminogen activating cascade	P01245	PAI-1	CANLF|Ensembl=ENSCAFG00000013909|UniProtKB=F1PUI4	Uncharacterized protein	ISS	10692390	PubMed	PTHR11461:SF49	PLASMINOGEN ACTIVATOR INHIBITOR 1
P00020	FAS signaling pathway	P00615	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	20986521	gi	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	RAT|RGD=3949|UniProtKB=P63045	Vesicle-associated membrane protein 2	ISS	8011337	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00837	PAK	ORNAN|Ensembl=ENSOANG00000002406|UniProtKB=F7BAS2	Uncharacterized protein	ISS	7559638	PubMed	PTHR24361:SF250	SERINE/THREONINE-PROTEIN KINASE PAK 3
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MOUSE|MGI=MGI=97602|UniProtKB=Q02956	Protein kinase C zeta type	IDA	97330413	PubMed	PTHR24356:SF170	PROTEIN KINASE C ZETA TYPE
P00057	Wnt signaling pathway	P01441	Glycogen Synthase Kinase-3Beta	PANTR|Ensembl=ENSPTRG00000015264|UniProtKB=H2QN60	Uncharacterized protein	ISS	12432063	PubMed	PTHR24057:SF8	GLYCOGEN SYNTHASE KINASE-3 BETA
P00012	Cadherin signaling pathway	P00470	F-actin	PHYPA|Gene=PHYPADRAFT_109052|UniProtKB=A9TZ58	Actin 5	ISS	14684598	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P04398	p53 pathway feedback loops 2	P04661	PI3K	PANTR|Ensembl=ENSPTRG00000016940|UniProtKB=H2QR04	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha)	ISS	12707323	PubMed	PTHR10155:SF3	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA
P00018	EGF receptor signaling pathway	P00559	MEK1-2	MOUSE|MGI=MGI=1346867|UniProtKB=Q63932	Dual specificity mitogen-activated protein kinase kinase 2	ISS	8380494	PubMed	PTHR24361:SF314	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
P00004	Alzheimer disease-presenilin pathway	P00135	Notch transmembrane fragment	RAT|RGD=3188|UniProtKB=Q9QW30	Neurogenic locus notch homolog protein 2	IDA	10206645	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00004	Alzheimer disease-presenilin pathway	P00140	Presenilin N-terminal fragment	DROME|FlyBase=FBgn0019947|UniProtKB=O02194	Presenilin homolog	IDA	12834808	PubMed	PTHR10202:SF13	PRESENILIN-2
P00018	EGF receptor signaling pathway	P00552	Ras	HUMAN|HGNC=5173|UniProtKB=P01112	GTPase HRas	ISS	87226391	PubMed	PTHR24070:SF385	GTPASE HRAS
P04394	Thyrotropin-releasing hormone receptor signaling pathway	P04581	PLC	MOUSE|MGI=MGI=107464|UniProtKB=Q91UZ1	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P04385	Histamine H1 receptor mediated signaling pathway	P04486	IP3R	CHICK|Ensembl=ENSGALG00000008294|UniProtKB=F1NZV1	Uncharacterized protein	ISS	95155356	PubMed	PTHR13715:SF52	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1
P00021	FGF signaling pathway	P00642	MEK1-2	CANLF|Ensembl=ENSCAFG00000017298|UniProtKB=J9P5W6	Uncharacterized protein	ISS	11730323	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00048	PI3 kinase pathway	P01194	S6K	ORNAN|Ensembl=ENSOANG00000002226|UniProtKB=F6TPX7	Ribosomal protein S6 kinase	ISS	15116068	PubMed	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
P05912	Dopamine receptor mediated signaling pathway	P05961	DOPA decarb.	CAEEL|WormBase=WBGene00001839|UniProtKB=P34751	Probable aromatic-L-amino-acid decarboxylase	ISS			PTHR11999:SF59	AROMATIC-L-AMINO-ACID DECARBOXYLASE-RELATED
P02756	N-acetylglucosamine metabolism	P03041	Glucosamine-6-phosphate deaminase	HUMAN|HGNC=21526|UniProtKB=Q8TDQ7	Glucosamine-6-phosphate isomerase 2	ISS			PTHR11280:SF9	GLUCOSAMINE-6-PHOSPHATE ISOMERASE 2
P00021	FGF signaling pathway	P00644	p38	BOVIN|Ensembl=ENSBTAG00000019574|UniProtKB=A5PJL3	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF146	MITOGEN-ACTIVATED PROTEIN KINASE 12
P05731	GABA-B receptor II signaling	P05754	Ggamma	CANLF|Ensembl=ENSCAFG00000019385|UniProtKB=E2R2S3	Guanine nucleotide-binding protein subunit gamma	ISS	3100519	PubMed	PTHR13809:SF8	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-7
P00034	Integrin signalling pathway	P00951	Jnk	XENTR|Xenbase=XB-GENE-1009840|UniProtKB=F7CYE3	Mitogen-activated protein kinase	ISS	20986510	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00005	Angiogenesis	P00205	GAP	PANTR|Ensembl=ENSPTRG00000017062|UniProtKB=H2QR74	RAS p21 protein activator (GTPase activating protein) 1	ISS	1375321	PubMed	PTHR10194:SF19	RAS GTPASE-ACTIVATING PROTEIN 1
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00726	Ggamma	PANTR|Ensembl=ENSPTRG00000002133|UniProtKB=H2Q1D9	Guanine nucleotide-binding protein subunit gamma	ISS	10391901	PubMed	PTHR13809:SF21	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-4
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	9851932	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P05916	Opioid prodynorphin pathway	P06002	G-protein	RAT|RGD=620243|UniProtKB=P04897	Guanine nucleotide-binding protein G(i) subunit alpha-2	ISS	10188796	PubMed	PTHR10218:SF73	GUANINE NUCLEOTIDE-BINDING PROTEIN G I  SUBUNIT ALPHA-2
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01071	NMDA	XENTR|Xenbase=XB-GENE-494200|UniProtKB=F7CS79	Uncharacterized protein	ISS	11554554	PubMed	PTHR44391:SF1	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1
P00042	Muscarinic acetylcholine receptor 1 and 3 signaling pathway	P01074	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	2837282	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P00047	PDGF signaling pathway	P01143	ERK	CHICK|Ensembl=ENSGALG00000006109|UniProtKB=E1C1H4	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00021	FGF signaling pathway	P00631	Grb2	DANRE|ZFIN=ZDB-GENE-041121-1|UniProtKB=Q5RKN6	Uncharacterized protein	ISS	10521483	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00018	EGF receptor signaling pathway	P00564	Rac	DANRE|ZFIN=ZDB-GENE-030131-5415|UniProtKB=Q7ZSZ9	Rac1	ISS	4757952	gi	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00034	Integrin signalling pathway	P00916	Ras	HUMAN|HGNC=7989|UniProtKB=P01111	GTPase NRas	IPI	1375321	PubMed	PTHR24070:SF189	GTPASE NRAS
P00057	Wnt signaling pathway	P01435	SWI/SNF	DEIRA|EnsemblGenome=DR_1259|UniProtKB=Q9RUX1	DNA helicase, SNF2/RAD54 family	IDA	11532957	PubMed	PTHR10799:SF845	SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A CONTAINING DEAD/H BOX 1
P00041	Metabotropic glutamate receptor group I pathway	P01059	PKA	MOUSE|MGI=MGI=97594|UniProtKB=P68181	cAMP-dependent protein kinase catalytic subunit beta	IC	15313841	PubMed	PTHR24353:SF116	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA
P00021	FGF signaling pathway	P00627	ERK1-2	ORYSJ|EnsemblGenome=OS06G0699400|UniProtKB=Q5Z859	Mitogen-activated protein kinase 4	ISS			PTHR24055:SF10	MITOGEN-ACTIVATED PROTEIN KINASE 7
P06587	Nicotine pharmacodynamics pathway	P06603	DRD2/ DRD3/ DRD4	MOUSE|MGI=MGI=94926|UniProtKB=P51436	D(4) dopamine receptor	ISS	1319557	PubMed	PTHR44250:SF1	D 4  DOPAMINE RECEPTOR
P05917	Opioid proopiomelanocortin pathway	P06005	SNARE Complex	MONDO|Ensembl=ENSMODG00000007792|UniProtKB=F7A943	Uncharacterized protein (Fragment)	ISS	14570579	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00035	Interferon-gamma signaling pathway	P00955	Serine kinase	CANLF|Ensembl=ENSCAFG00000009396|UniProtKB=F1PMN2	Mitogen-activated protein kinase	ISS	11790551	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P00053	T cell activation	P01336	Jnk	CHICK|Ensembl=ENSGALG00000011109|UniProtKB=E1C8C5	Mitogen-activated protein kinase	ISS	8177321	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P06664	Gonadotropin-releasing hormone receptor pathway	P06777	NFAT	MOUSE|MGI=MGI=103296|UniProtKB=P97305	Nuclear factor of activated T-cells, cytoplasmic 3	RCA	9462517	PubMed	PTHR12533:SF6	NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3
P00052	TGF-beta signaling pathway	P01282	Co-activators corepressors	BOVIN|Gene=JUN|UniProtKB=O77627	Transcription factor AP-1	ISS	14993273	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00029	Huntington disease	P00787	MAPKK4	MACMU|Ensembl=ENSMMUG00000019842|UniProtKB=F7FU91	Uncharacterized protein	ISS	12040174	PubMed	PTHR24361:SF376	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
P00046	Oxidative stress response	P01135	p38	DROME|FlyBase=FBgn0015765|UniProtKB=O62618	Mitogen-activated protein kinase 14A	TAS	98079070	PubMed	PTHR24055:SF238	MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
P00002	Alpha adrenergic receptor signaling pathway	P00073	PLC	PANTR|Ensembl=ENSPTRG00000013242|UniProtKB=H2QJY5	Phosphoinositide phospholipase C	ISS	8407970	PubMed	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4
P00046	Oxidative stress response	P01131	MKP5	MACMU|Ensembl=ENSMMUG00000009858|UniProtKB=F6YZQ7	Dual specificity protein phosphatase	ISS			PTHR10159:SF40	DUAL SPECIFICITY PROTEIN PHOSPHATASE 5
P04374	5HT2 type receptor mediated signaling pathway	P04420	PKC	DANRE|ZFIN=ZDB-GENE-041001-104|UniProtKB=Q5TZD4	Protein kinase C	ISS	2837282	PubMed	PTHR24356:SF192	PROTEIN KINASE C ETA TYPE
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00847	CaMK	BOVIN|Ensembl=ENSBTAG00000012653|UniProtKB=Q3MHJ9	Calcium/calmodulin-dependent protein kinase type II subunit beta	ISS	12888804	PubMed	PTHR43940:SF3	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT BETA
P00006	Apoptosis signaling pathway	P00274	JNK	MOUSE|MGI=MGI=1346863|UniProtKB=Q61831	Mitogen-activated protein kinase 10	ISS	10523642	PubMed	PTHR24055:SF162	MITOGEN-ACTIVATED PROTEIN KINASE 10
P04393	Ras Pathway	P04560	AP1	MOUSE|MGI=MGI=96646|UniProtKB=P05627	Transcription factor AP-1	ISS	10421778	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P00056	VEGF signaling pathway	P01413	PI3K	XENTR|Xenbase=XB-GENE-998106|UniProtKB=F6VXG1	Uncharacterized protein	ISS	11903815	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	PANTR|Ensembl=ENSPTRG00000011890|UniProtKB=H2QHV0	Protein kinase C epsilon type	ISS	10644715	PubMed	PTHR24356:SF159	PROTEIN KINASE C EPSILON TYPE
P04377	Beta1 adrenergic receptor signaling pathway	P04434	ER-type Ca2+ channel	MACMU|Ensembl=ENSMMUG00000001060|UniProtKB=F6QN17	Uncharacterized protein	ISS	15858232	PubMed	PTHR13715:SF75	RYANODINE RECEPTOR 2
P06959	CCKR signaling map	P07213	c-RAF / RAF1	HUMAN|HGNC=9829|UniProtKB=P04049	RAF proto-oncogene serine/threonine-protein kinase	RCA	7794806	PubMed	PTHR44000:SF1	RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
P00010	B cell activation	P00368	vav	MOUSE|MGI=MGI=102718|UniProtKB=Q60992	Guanine nucleotide exchange factor VAV2	IGI	14623913	PubMed	PTHR22826:SF95	GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV2
P00036	Interleukin signaling pathway	P00965	ERK	MONDO|Ensembl=ENSMODG00000004896|UniProtKB=F7C2C6	Uncharacterized protein (Fragment)	ISS	8444355	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00019	Endothelin signaling pathway	P00577	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	1322797	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P00056	VEGF signaling pathway	P01408	Akt/PKB	CANLF|Ensembl=ENSCAFG00000018354|UniProtKB=E2RJX4	Uncharacterized protein	ISS	4885061	gi	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00003	Alzheimer disease-amyloid secretase pathway	P00099	MAPK	MONDO|Ensembl=ENSMODG00000009766|UniProtKB=F6TFL4	Uncharacterized protein	ISS	11790551	PubMed	PTHR24055:SF171	MITOGEN-ACTIVATED PROTEIN KINASE 6
P00006	Apoptosis signaling pathway	P00274	JNK	PANTR|Ensembl=ENSPTRG00000002478|UniProtKB=H2R0G7	Mitogen-activated protein kinase	ISS	10514528	PubMed	PTHR24055:SF222	MITOGEN-ACTIVATED PROTEIN KINASE 8
P00004	Alzheimer disease-presenilin pathway	P00176	Notch	MACMU|Ensembl=ENSMMUG00000018375|UniProtKB=F7H1D5	Neurogenic locus notch homolog protein 2 isoform 1 preproprotein	ISS	1295745	PubMed	PTHR43959:SF5	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2
P00016	Cytoskeletal regulation by Rho GTPase	P00512	Actin	BOVIN|Ensembl=ENSBTAG00000006189|UniProtKB=P63258	Actin, cytoplasmic 2	ISS	3487386	PubMed	PTHR11937:SF362	ACTIN, CYTOPLASMIC 2
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00858	F-actin	TRIAD|EnsemblGenome=TriadG63375|UniProtKB=B3S5E4	Non-muscle actin 6.2	ISS	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P05917	Opioid proopiomelanocortin pathway	P06009	K+ channel	DANRE|ZFIN=ZDB-GENE-040724-171|UniProtKB=Q5TZ59	Uncharacterized protein	ISS	12882230	PubMed	PTHR11003:SF138	POTASSIUM CHANNEL SUBFAMILY K MEMBER 3
P00044	Nicotinic acetylcholine receptor signaling pathway	P01090	Actin	STRPU|EnsemblGenome=SPU_006797|UniProtKB=W4XTP5	Uncharacterized protein	IC	10974003	PubMed	PTHR11937:SF155	ACTIN-5C-RELATED
P00057	Wnt signaling pathway	P01451	Galpha	HUMAN|HGNC=4390|UniProtKB=P50148	Guanine nucleotide-binding protein G(q) subunit alpha	IDA	9166716	PubMed	PTHR10218:SF184	GUANINE NUCLEOTIDE-BINDING PROTEIN G Q  SUBUNIT ALPHA
P05916	Opioid prodynorphin pathway	P05996	SNARE Complex	MACMU|Ensembl=ENSMMUG00000020384|UniProtKB=F6UFJ7	Synaptosomal-associated protein 29	ISS	12475239	PubMed	PTHR19305:SF9	SYNAPTOSOMAL-ASSOCIATED PROTEIN 29
P00047	PDGF signaling pathway	P01168	PI3K	CANLF|Ensembl=ENSCAFG00000003977|UniProtKB=E2RCV1	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF34	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
P00010	B cell activation	P00391	PI3K	MOUSE|MGI=MGI=1206581|UniProtKB=P42337	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IDA	12707323	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05915	Opioid proenkephalin pathway	P05986	SNARE Complex	HUMAN|HGNC=12643|UniProtKB=P63027	Vesicle-associated membrane protein 2	IC	93386758	PubMed	PTHR21136:SF91	VESICLE-ASSOCIATED MEMBRANE PROTEIN 2
P00047	PDGF signaling pathway	P01148	Grb2	MOUSE|MGI=MGI=95805|UniProtKB=Q60631	Growth factor receptor-bound protein 2	ISS	8235613	PubMed	PTHR24418:SF290	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
P00048	PI3 kinase pathway	P01185	SOS	MACMU|Ensembl=ENSMMUG00000007464|UniProtKB=F6SW06	Uncharacterized protein	ISS	8621483	PubMed	PTHR23113:SF150	SON OF SEVENLESS HOMOLOG 2
P00033	Insulin/IGF pathway-protein kinase B signaling cascade	P00900	PI3K	RAT|Ensembl=ENSRNOG00000056810|UniProtKB=A0A0G2K5T3	Protein LOC685590	ISS	11756681	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P04373	5HT1 type receptor mediated signaling pathway	P04408	G-protein	PANTR|Ensembl=ENSPTRG00000001055|UniProtKB=H2PZK9	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	ISS	11535291	PubMed	PTHR10218:SF230	GUANINE NUCLEOTIDE-BINDING PROTEIN G K  SUBUNIT ALPHA
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00734	Rap1	BOVIN|Ensembl=ENSBTAG00000008967|UniProtKB=P61223	Ras-related protein Rap-1b	ISS	10476970	PubMed	PTHR24070:SF278	RAS-RELATED PROTEIN RAP-1B-RELATED
P00027	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	P00745	PKC	MACMU|Ensembl=ENSMMUG00000020776|UniProtKB=F7HC75	Protein kinase C	ISS	10395542	PubMed	PTHR24356:SF181	PROTEIN KINASE C THETA TYPE
P00047	PDGF signaling pathway	P01160	IP3 receptor	RAT|RGD=2934|UniProtKB=Q63269	Inositol 1,4,5-trisphosphate receptor type 3	ISS	12529267	PubMed	PTHR13715:SF51	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3
P00052	TGF-beta signaling pathway	P01278	TGFbetareceptor I	DROME|Gene=Dmel_CG1891|UniProtKB=A0A0B4K7J3	Receptor protein serine/threonine kinase	TAS	9395284	PubMed	PTHR23255:SF72	RECEPTOR PROTEIN SERINE/THREONINE KINASE
P00018	EGF receptor signaling pathway	P00565	PKC	BOVIN|Gene=PRKCG|UniProtKB=P05128	Protein kinase C gamma type (Fragment)	IGI	2611232	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00059	p53 pathway	P04630	PP2A	RAT|RGD=3380|UniProtKB=P63331	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	ISS	1662645	PubMed	PTHR11668:SF379	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM
P02788	Xanthine and guanine salvage pathway	P03245	Guanine phosphoribosyl transferase	CAEBR|Gene=CBG19800|UniProtKB=A8XWA1	Protein CBG19800	ISS			PTHR43340:SF1	HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE HOMOLOG
P04385	Histamine H1 receptor mediated signaling pathway	P04487	PKC	HUMAN|HGNC=9402|UniProtKB=P05129	Protein kinase C gamma type	ISS	11032873	PubMed	PTHR24356:SF162	PROTEIN KINASE C GAMMA TYPE
P00011	Blood coagulation	P00415	Plasmin	MOUSE|MGI=MGI=97620|UniProtKB=P20918	Plasminogen	ISS	16758216	gi	PTHR24261:SF5	PLASMINOGEN
P00016	Cytoskeletal regulation by Rho GTPase	P00526	tubulin	PHYPA|Gene=PHYPADRAFT_186458|UniProtKB=Q6TYR7	Beta-tubulin 1	ISS	12932731	PubMed	PTHR11588:SF241	SUBFAMILY NOT NAMED
P00002	Alpha adrenergic receptor signaling pathway	P00074	SNARE	MACMU|Ensembl=ENSMMUG00000011064|UniProtKB=P60877	Synaptosomal-associated protein 25	ISS	10414292	PubMed	PTHR19305:SF5	SYNAPTOSOMAL-ASSOCIATED PROTEIN 25
P00053	T cell activation	P01312	MEK	PANTR|Gene=MAP2K1|UniProtKB=Q9XT09	Dual specificity mitogen-activated protein kinase kinase 1	ISS	8039496	PubMed	PTHR24361:SF370	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
P00004	Alzheimer disease-presenilin pathway	P00119	Frizzled	DROME|FlyBase=FBgn0001085|UniProtKB=P18537	Frizzled	TAS	8717036	PubMed	PTHR11309:SF47	FRIZZLED
P00008	Axon guidance mediated by Slit/Robo	P00354	Rac	XENTR|Xenbase=XB-GENE-489008|UniProtKB=Q6GL60	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)	ISS	21244534	PubMed	PTHR24072:SF105	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
P00036	Interleukin signaling pathway	P00970	Interleukin	MOUSE|MGI=MGI=107936|UniProtKB=P70380	Interleukin-18	IDA	11123331	PubMed	PTHR45200:SF1	INTERLEUKIN-18
P04380	Cortocotropin releasing factor receptor signaling pathway	P04456	ProCRF (Pro Corticotropin-Releasing Factor)	CHICK|Ensembl=ENSGALG00000015521|UniProtKB=Q703P0	Corticotropin releasing hormone	ISS	122560	OMIM	PTHR15035:SF9	CORTICOLIBERIN
P00059	p53 pathway	P04609	PI3K	ORNAN|Ensembl=ENSOANG00000013922|UniProtKB=F7DUD6	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF54	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
P05731	GABA-B receptor II signaling	P05754	Ggamma	RAT|RGD=620808|UniProtKB=P63077	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	ISS	3100519	PubMed	PTHR13809:SF19	GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O  SUBUNIT GAMMA-8
P00018	EGF receptor signaling pathway	P00557	PI3K	MONDO|Ensembl=ENSMODG00000018581|UniProtKB=F7FDA0	Uncharacterized protein	ISS	14526383	PubMed	PTHR10048:SF33	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
P00056	VEGF signaling pathway	P01411	Ras	PANTR|Ensembl=ENSPTRG00000001140|UniProtKB=H2PZQ7	Neuroblastoma RAS viral (V-ras) oncogene homolog	ISS	3133626	PubMed	PTHR24070:SF189	GTPASE NRAS
P00048	PI3 kinase pathway	P01199	Galpha	XENTR|Xenbase=XB-GENE-945095|UniProtKB=Q66JF0	Guanine nucleotide binding protein (G protein), alpha 14	ISS	1333286	PubMed	PTHR10218:SF213	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14
P00031	Inflammation mediated by chemokine and cytokine signaling pathway	P00827	AKT	MOUSE|MGI=MGI=87986|UniProtKB=P31750	RAC-alpha serine/threonine-protein kinase	TAS	11135576	PubMed	PTHR24356:SF171	RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE
P00036	Interleukin signaling pathway	P00983	Raf	PANTR|Ensembl=ENSPTRG00000019769|UniProtKB=H2QVI0	Uncharacterized protein	ISS	125651	gi	PTHR44000:SF3	SERINE/THREONINE-PROTEIN KINASE B-RAF
P00029	Huntington disease	P00776	c-Jun	CANLF|Ensembl=ENSCAFG00000018897|UniProtKB=E2R6T4	Uncharacterized protein	ISS	11724916	PubMed	PTHR11462:SF8	TRANSCRIPTION FACTOR AP-1
P04377	Beta1 adrenergic receptor signaling pathway	P04438	Ca2+ channel	MOUSE|MGI=MGI=1859639|UniProtKB=Q9JIS7	Voltage-dependent L-type calcium channel subunit alpha-1F	IC	8838325	PubMed	PTHR10037:SF184	VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F
P00037	Ionotropic glutamate receptor pathway	P01025	A/K	PANTR|Ensembl=ENSPTRG00000000543|UniProtKB=H2PYN8	Uncharacterized protein	ISS	12941441	PubMed	PTHR18966:SF174	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3
P00019	Endothelin signaling pathway	P00569	Adenylate cyclase	CANLF|Ensembl=ENSCAFG00000019237|UniProtKB=E2R4W4	Uncharacterized protein	ISS	2491850	PubMed	PTHR11920:SF319	ADENYLATE CYCLASE TYPE 9
P00029	Huntington disease	P00786	ARF	RAT|RGD=1306875|UniProtKB=B2RZ70	ADP-ribosylation factor 4-like	ISS	12932731	PubMed	PTHR11711:SF137	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 4D